RHEA:54381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => 5-hydroxy-alpha-gurjunene + diphosphate
REACT:R-BTA-8874082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates PTK2 (Bos taurus)
RHEA:11199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide <=> alpha-ribazole 5'-phosphate + H(+) + nicotinate
RHEA:16002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N(6)-methyl-AMP => IMP + methylamine
REACT:R-CFA-388503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxytocin receptor bind oxytocin (Canis familiaris)
RHEA:12484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate
RHEA:12484	skos:prefLabel	"5'-nucleotidase"
RHEA:12484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5'-nucleotidase"
RHEA:62348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide C
RHEA:42320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:31868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => baccharis oxide
REACT:R-BTA-5690701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 binds p-CD22 (Bos taurus)
GO:0005287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity basic amino acid transmembrane transporter activity
GO:0005287	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	high-affinity basic amino acid transporter activity
GO:0005287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity basic amino acid transmembrane transporter activity
RHEA:55803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:54976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanoyl-CoA + H2O = (3S)-hydroxytetradecanoate + CoA + H(+)
RHEA:41443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 <=> (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate
RHEA:54882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-isopropenyl-6-oxoheptanoate + H(+) => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one
REACT:R-RNO-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Rattus norvegicus)
RHEA:31481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP => soyasapogenol A + UDP-alpha-D-glucuronate
REACT:R-BTA-2730847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP2 by PLCG (Bos taurus)
REACT:R-XTR-8854628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLIP dimer ubiquitinates VLDLR on Lys-839 (Xenopus tropicalis)
REACT:R-SPO-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Schizosaccharomyces pombe)
RHEA:11573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + H2O + lithocholate => chenodeoxycholate + FADH2
REACT:R-HSA-193786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)
RHEA:31902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-8875817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates STAT3 (Caenorhabditis elegans)
REACT:R-SPO-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Schizosaccharomyces pombe)
REACT:R-CEL-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Caenorhabditis elegans)
REACT:R-SPO-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Schizosaccharomyces pombe)
RHEA:47706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochalasin Z16 + H2O + NADP(+) => H(+) + iso-precytochalasin + NADPH + O2
REACT:R-RNO-1454781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Rattus norvegicus)
RHEA:64280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-phenylethylamine + pyruvate = acetophenone + L-alanine
REACT:R-DRE-2161282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastic fibres bind associated proteins (Danio rerio)
RHEA:51597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-PFA-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Plasmodium falciparum)
REACT:R-HSA-1655825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:SCAP binds CopII Coat Complex (Homo sapiens)
GO:0001586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serotonin receptor activity, coupled via Gi/o
GO:0001586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi/o-coupled serotonin receptor activity
GO:0001586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT1 receptor activity
RHEA:68153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,3-diacylglycerol + a fatty acyl-CoA => a triacylglycerol + CoA
REACT:R-CEL-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Caenorhabditis elegans)
REACT:R-RNO-9654521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin dissociates KRAS4B from the plasma membrane (Rattus norvegicus)
RHEA:45802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-decarboxymethylaclacinomycin T + A + CO2 + H2O => 15-demethylaclacinomycin T + AH2 + O2
REACT:R-CEL-433099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS2 co-transports sulphate and two sodium ions (Caenorhabditis elegans)
REACT:R-DRE-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Danio rerio)
RHEA:44724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-saturated fatty aldehyde + NADP(+) = (2E)-fatty aldehyde + H(+) + NADPH
REACT:R-DRE-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Danio rerio)
RHEA:66527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(in) + monodehydro-L-ascorbate radical(out) <=> L-ascorbate(out) + monodehydro-L-ascorbate radical(in)
RHEA:15415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate => (2R,3R)-tartrate
GO:0051669	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-fructan fructohydrolase activity
GO:0051669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructan b-fructosidase activity
GO:0051669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructan beta-fructosidase"
GO:0051669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-beta-fructosidase activity
GO:0051669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polysaccharide beta-fructofuranosidase activity
GO:0051669	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructanase activity
GO:0051669	skos:altLabel	"exo-beta-D-fructosidase"
GO:0051669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructan beta-fructosidase activity
GO:0051669	skos:altLabel	"fructanase"
GO:0051669	skos:prefLabel	"fructan beta-fructosidase"
GO:0051669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-beta-D-fructosidase activity
GO:0051669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructan exohydrolase activity
RHEA:42335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + oxidized coenzyme F420-2 <=> ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate
REACT:R-SSC-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Sus scrofa)
REACT:R-MMU-5654669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Mus musculus)
REACT:R-XTR-159836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)
REACT:R-MMU-6782138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC5 and RPA bind TC-NER site (Mus musculus)
REACT:R-XTR-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Xenopus tropicalis)
REACT:R-XTR-6798317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Xenopus tropicalis)
REACT:R-BTA-5323526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRAT proteins bind GSK3beta (Bos taurus)
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc pyrophosphorylase activity
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine diphosphorylase activity
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine pyrophosphorylase activity
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosamine-1-phosphate uridyltransferase activity
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetylglucosamine 1-phosphate uridylyltransferase
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine pyrophosphorylase activity
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlmU uridylyltransferase activity
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine phosphorylase activity
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity
GO:0003977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-acetylglucosamine pyrophosphorylase activity
REACT:R-XTR-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Xenopus tropicalis)
RHEA:50968	skos:prefLabel	"tRNA(Ala)(adenine(37)) deaminase"
RHEA:50968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+)
RHEA:50968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Ala)(adenine(37)) deaminase"
RHEA:72396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(out) + K(+)(out) + Na(+)(out) => 2 chloride(in) + K(+)(in) + Na(+)(in)
RHEA:29078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(out) + 2 H(+)(in) + ubiquinone-8 <=> CO2(out) + H(+)(out) + ubiquinol-8
RHEA:20024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + deoxyamidinoproclavaminate + O2 <=> amidinoproclavaminate + CO2 + succinate
REACT:R-DRE-163756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of fatty acid synthase (FAS) dimer (Danio rerio)
REACT:R-MMU-6805638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A acetylates TP53 (Mus musculus)
REACT:R-HSA-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Homo sapiens)
REACT:R-BTA-2105001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from DS (Bos taurus)
RHEA:19486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP
REACT:R-RNO-2130619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosomal vesicle coat assembly (Rattus norvegicus)
RHEA:52633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP
RHEA:71515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine(out) = hypoxanthine(in)
REACT:R-HSA-5659926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SI does not hydrolyze Suc (Homo sapiens)
REACT:R-XTR-9708558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Xenopus tropicalis)
REACT:R-DDI-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Dictyostelium discoideum)
REACT:R-BTA-9020261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Bos taurus)
RHEA:33179	skos:altLabel	"1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase"
RHEA:33179	skos:altLabel	"PI-PLC"
RHEA:33179	skos:altLabel	"triphosphoinositide phosphodiesterase"
RHEA:33179	skos:altLabel	"phosphatidylinositol phospholipase C"
RHEA:33179	skos:altLabel	"1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase"
RHEA:33179	skos:altLabel	"phosphoinositidase C"
RHEA:33179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)
RHEA:33179	skos:altLabel	"monophosphatidylinositol phosphodiesterase"
RHEA:33179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoinositide phospholipase C"
RHEA:33179	skos:prefLabel	"phosphoinositide phospholipase C"
REACT:R-RNO-3769391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 binds the beta-catenin:CBY complex (Rattus norvegicus)
RHEA:50579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]
REACT:R-HSA-8850777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK14 (Homo sapiens)
REACT:R-DME-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)
REACT:R-RNO-1977959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with EGFR (Rattus norvegicus)
REACT:R-HSA-9692376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL2 binds BCL2 antagonists (Homo sapiens)
REACT:R-GGA-2395412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SYK (Gallus gallus)
REACT:R-BTA-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Bos taurus)
REACT:R-MMU-202291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Lck (Mus musculus)
REACT:R-SSC-110251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of hypoxanthine by MPG glycosylase (Sus scrofa)
RHEA:65588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:30266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + 2 L-ascorbate <=> 2 H2O + 2 monodehydro-L-ascorbate radical
REACT:R-HSA-210298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and KIR3DS1 (Homo sapiens)
REACT:R-MMU-8981622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin:oxygen dissociates (Mus musculus)
RHEA:59345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + O2 => D-maltobiono-1,5-lactone + H2O2
REACT:R-HSA-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)
RHEA:45202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein]
REACT:R-CFA-4615900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB2 with SUMO3 (Canis familiaris)
REACT:R-HSA-9736992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter (Homo sapiens)
GO:0047416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylarylalkylamine amidohydrolase activity
GO:0047416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylalkyl acylamidase activity
GO:0047416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aralkyl acylamidase activity
REACT:R-RNO-164832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase synthesizes ATP (Rattus norvegicus)
RHEA:55087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxypentanoyl-CoA + H2O <=> (3R)-3-hydroxypentanoate + CoA + H(+)
GO:0001052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plastid PEP RNA polymerase core enzyme binding
REACT:R-RNO-6786720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DECR2 reduces LCtE-CoA to t3enoyl-CoA (Rattus norvegicus)
REACT:R-HSA-3245898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds correnoids in the circulation (Homo sapiens)
REACT:R-DRE-444879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 2 binds relaxin 2 and INSL3 (Danio rerio)
RHEA:45227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA <=> (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA
REACT:R-DRE-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Danio rerio)
GO:0140777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-containing complex stabilizing activity
RHEA:36818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-fucose <=> dTDP-alpha-D-fucofuranose
REACT:R-GGA-351478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of gamma-H2AX with MCPH1 (Gallus gallus)
REACT:R-HSA-174438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate on the C-strand (Homo sapiens)
REACT:R-MMU-158747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Mus musculus)
RHEA:62753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pravastatin lactone => (S)-2-methylbutanoate + H(+) + pravastatin diol lactone
REACT:R-RNO-5661125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2sR4-HIST1H4 (Rattus norvegicus)
GO:0004660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein farnesyltransferase activity
GO:0004660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
GO:0004660	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CAAX farnesyltransferase activity
GO:0004660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FTase activity
GO:0004660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-cysteine farnesyltransferase activity
REACT:R-RNO-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Rattus norvegicus)
RHEA:49832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH
RHEA:18084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + pentalenene
RHEA:62613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine
REACT:R-BTA-109480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)
REACT:R-SCE-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Saccharomyces cerevisiae)
RHEA:24536	skos:altLabel	"tryptamine 2,3-dioxygenase"
RHEA:24536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan 2,3-dioxygenase"
RHEA:24536	skos:altLabel	"indolamine 2,3-dioxygenase"
RHEA:24536	skos:altLabel	"tryptophan peroxidase"
RHEA:24536	skos:altLabel	"tryptamin 2,3-dioxygenase"
RHEA:24536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 = N-formyl-L-kynurenine
RHEA:24536	skos:prefLabel	"tryptophan 2,3-dioxygenase"
RHEA:24536	skos:altLabel	"tryptophan pyrrolase"
RHEA:24536	skos:altLabel	"L-tryptophan pyrrolase"
RHEA:24536	skos:altLabel	"indoleamine 2,3-dioxygenase"
RHEA:24536	skos:altLabel	"L-tryptophan 2,3-dioxygenase"
RHEA:24536	skos:altLabel	"tryptophanase"
RHEA:24536	skos:altLabel	"tryptophan oxygenase"
REACT:R-BTA-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
GO:0140931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral L-amino acid:sodium:chloride symporter activity
GO:0140931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral amino acid:sodium:chloride symporter activity
REACT:R-GGA-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Gallus gallus)
REACT:R-BTA-1606602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Bos taurus)
GO:1900995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquinone-6 binding
REACT:R-DME-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Drosophila melanogaster)
REACT:R-SSC-176474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Sus scrofa)
REACT:R-BTA-5618331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC6 deacetylates microtubules (Bos taurus)
RHEA:35482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'R)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + 2 H(+) + NADH
EC:3.4.23.3	skos:altLabel	"pepsin C"
EC:3.4.23.3	skos:prefLabel	"gastricsin"
EC:3.4.23.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gastricsin"
RHEA:10054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + H(+) + NADH => (R)-2-hydroxy-4-methylpentanoate + NAD(+)
REACT:R-DME-5690196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates RNF128 (Drosophila melanogaster)
GO:0051408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity
GO:0015233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B5 transmembrane transporter activity
GO:0015233	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pantothenate transporter activity
GO:0015233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pantothenate transmembrane transporter activity
RHEA:44581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) => 2-all-trans-decaprenylphenol + CO2
REACT:R-SSC-873951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1:HSP90 binds inactive NLRP3 (Sus scrofa)
REACT:R-MMU-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)
REACT:R-SSC-9648089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6 and NEK7 phosphorylate EML4 (Sus scrofa)
REACT:R-HSA-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Homo sapiens)
RHEA:20764	skos:altLabel	"transcarboxylase"
RHEA:20764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + pyruvate = oxaloacetate + propanoyl-CoA
RHEA:20764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylmalonyl-CoA carboxytransferase"
RHEA:20764	skos:altLabel	"methylmalonyl-CoA carboxyltransferase"
RHEA:20764	skos:prefLabel	"methylmalonyl-CoA carboxytransferase"
RHEA:71229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + selenocyanate(in) => 2 Na(+)(out) + selenocyanate(out)
GO:0019114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol dioxygenase activity
REACT:R-CEL-8871265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD4 (Caenorhabditis elegans)
REACT:R-SSC-158218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)
REACT:R-XTR-5423038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)
REACT:R-CEL-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Caenorhabditis elegans)
REACT:R-HSA-194800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botE LC cleaves target cell SNAP25 (Homo sapiens)
REACT:R-CFA-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Canis familiaris)
REACT:R-RNO-430190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds NCK (Rattus norvegicus)
RHEA:62605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate
REACT:R-GGA-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Gallus gallus)
RHEA:18961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allose + L-lysyl-[protein] = H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]
REACT:R-CFA-5362500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Canis familiaris)
REACT:R-SPO-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Schizosaccharomyces pombe)
GO:0008115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sarcosine oxidase activity
GO:0008115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sarcosine:oxygen oxidoreductase (demethylating)
REACT:R-SSC-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Sus scrofa)
RHEA:48632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O
RHEA:59663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotetraose + O2 <=> D-cellotetraono-1,5-lactone + H2O2
REACT:R-RNO-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Rattus norvegicus)
RHEA:58464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP
REACT:R-HSA-1912386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of NOTCH1 by ITCH in the absence of ligand (Homo sapiens)
REACT:R-CFA-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Canis familiaris)
RHEA:19861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16alpha-hydroxysteroid + NAD(+) = a 16-oxosteroid + H(+) + NADH
RHEA:72241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(in) + L-glutamate(out) => estrone 3-sulfate(out) + L-glutamate(in)
REACT:R-PFA-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Plasmodium falciparum)
REACT:R-CFA-8869506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)
REACT:R-DRE-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Danio rerio)
REACT:R-DRE-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Danio rerio)
REACT:R-RNO-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Rattus norvegicus)
REACT:R-HSA-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Homo sapiens)
REACT:R-MMU-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Mus musculus)
RHEA:18297	skos:altLabel	"o-phthalyl amidase"
RHEA:18297	skos:prefLabel	"phthalyl amidase"
RHEA:18297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phthalyl amidase"
RHEA:18297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phtalamide + H2O = a primary amine + phthalate
REACT:R-CEL-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Caenorhabditis elegans)
REACT:R-DRE-8848658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Danio rerio)
GO:0033770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisoflavanone synthase activity
GO:0033770	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	liquiritigenin,NADPH:oxygen oxidoreductase activity
GO:0033770	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	naringenin,NADPH:oxygen oxidoreductase activity
GO:0033770	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isoflavonoid synthase
REACT:R-GGA-9624526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Gallus gallus)
REACT:R-DRE-173725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C9 binds C5b:C6:C7:C8 (Danio rerio)
REACT:R-GGA-166538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The bound receptor dimerizes (Gallus gallus)
REACT:R-HSA-9687435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enhanced autophagosome formation (Homo sapiens)
REACT:R-HSA-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Homo sapiens)
RHEA:72662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + quinolin-8-ol <=> 8-hydroxyquinoline N-oxide + H2O + NADP(+)
REACT:R-CEL-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
REACT:R-CFA-5661116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me3K5-histone H3 (Canis familiaris)
REACT:R-GGA-451481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR7 binds to recognized ligands (Gallus gallus)
GO:0120159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	23S rRNA pseudouridine(2457) synthase
GO:0120159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	23S rRNA pseudouridine(955/2504/2580) synthase
GO:0120159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	21S rRNA pseudouridine(2819) synthase
GO:0120159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	23S rRNA pseudouridine(2605) synthase
GO:0120159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA pseudouridine synthase activity
GO:0120159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	23S rRNA pseudouridine(1911/1915/1917) synthase
GO:0120159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	16S rRNA pseudouridine(516) synthase
GO:0120159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	23S rRNA pseudouridine(746) synthase
GO:0120159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	23S rRNA pseudouridine(2604) synthase
GO:0036361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	racemase activity, acting on amino acids and derivatives
REACT:R-GGA-8986994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Gallus gallus)
RHEA:27987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyacetone + NADP(+) => H(+) + methylglyoxal + NADPH
REACT:R-SSC-5692315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OX40L binds OX40 (Sus scrofa)
RHEA:35292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-methyldodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxoisopentadecanoyl-CoA + CO2 + CoA
RHEA:34529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-3-phenylpropanoate => L-phenylalanine
RHEA:15689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-2,4-diaminobutanoate = CO2 + propane-1,3-diamine
RHEA:15689	skos:altLabel	"L-2,4-diaminobutanoate carboxy-lyase"
RHEA:15689	skos:altLabel	"DABA DC"
RHEA:15689	skos:altLabel	"L-2,4-diaminobutyrate decarboxylase"
RHEA:15689	skos:prefLabel	"diaminobutyrate decarboxylase"
RHEA:15689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diaminobutyrate decarboxylase"
REACT:R-MMU-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Mus musculus)
RHEA:70393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-eicosanoyl-3-oxosphinganine => 3-oxosphinganine + eicosanoyl-CoA
GO:0106359	skos:altLabel	"2-hydroxyphytanoyl-CoA lyase"
GO:0106359	skos:prefLabel	"2-hydroxyacyl-CoA lyase"
GO:0106359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyacyl-CoA lyase"
GO:0106359	skos:altLabel	"2-HPCL"
GO:0106359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyacyl-CoA lyase activity
REACT:R-HSA-9769347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated glucocorticoid receptor binds NPAS4 gene promoter (Homo sapiens)
REACT:R-SSC-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Sus scrofa)
REACT:R-SSC-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Sus scrofa)
REACT:R-CEL-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
RHEA:48675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-6785213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer binds heparin (Danio rerio)
REACT:R-HSA-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Homo sapiens)
RHEA:36161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin]
REACT:R-CFA-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Canis familiaris)
RHEA:51552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + NADP(+) = H(+) + L-xylo-3-hexulose + NADPH
REACT:R-BTA-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Bos taurus)
REACT:R-BTA-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Bos taurus)
REACT:R-HSA-141439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of activated MAD2 from kinetochores (Homo sapiens)
GO:0015276	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ionotropic receptor activity
GO:0015276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-gated ion channel activity
RHEA:31057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + H(+) + sulfate => estrone 3-sulfate + H2O
RHEA:34726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine 1-phosphate + H2O <=> 15-methylhexadecasphing-4-enine + phosphate
EC:7.4.-.-	skos:prefLabel	"Catalysing the translocation amino acids and peptides"
EC:7.4.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Catalysing the translocation amino acids and peptides"
RHEA:70925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline(in) + chloride(in) + Na(+)(in) => (R)-noradrenaline(out) + chloride(out) + Na(+)(out)
REACT:R-RNO-5626988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds NSMAF (Rattus norvegicus)
REACT:R-MMU-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Mus musculus)
REACT:R-RNO-8864343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD1 binds TFAP2 homo- and heterodimers (Rattus norvegicus)
REACT:R-HSA-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Homo sapiens)
REACT:R-BTA-8938356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RMB14 binds RUNX2 (Bos taurus)
RHEA:72860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-c-tri-AMP + H2O => A[3'-5']pA[3'-5']pAp[3'] + H(+)
REACT:R-MMU-177479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Axonal transport of NGF:Trk complexes (Mus musculus)
REACT:R-RNO-192061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)
REACT:R-MMU-9018863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Mus musculus)
RHEA:12133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate
REACT:R-BTA-5684865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB dimer,C translocate from multivesicle body to lamellar body (Bos taurus)
REACT:R-GGA-964811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5AR2 binds anaphylatoxins and thier desArginated derivatives (Gallus gallus)
RHEA:47005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-threonyl-[protein] => L-threonyl-[protein] + phosphate
GO:0035478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron binding
RHEA:17361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-malonylurea hydrolase"
RHEA:17361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-3-ureidopropanoate + H2O = H(+) + malonate + urea
RHEA:17361	skos:altLabel	"ureidomalonase"
RHEA:17361	skos:prefLabel	"N-malonylurea hydrolase"
REACT:R-CFA-5618105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Canis familiaris)
REACT:R-DRE-8848818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CBL (Danio rerio)
RHEA:72002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II
RHEA:36136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenal + H2O + NAD(+) => (E)-hexadec-2-enoate + 2 H(+) + NADH
REACT:R-BTA-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Bos taurus)
REACT:R-CFA-9724745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds aprotinin (Canis familiaris)
REACT:R-DME-5205681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is cleaved on healthy mitochondria (Drosophila melanogaster)
GO:0050002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-proline reductase (dithiol) activity
GO:0050002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminopentanoate:lipoate oxidoreductase (cyclizing)
GO:0050002	skos:prefLabel	"D-proline reductase"
GO:0050002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-proline reductase"
GO:0050002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline
REACT:R-GGA-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Gallus gallus)
RHEA:39266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH <=> (13Z)-docosenoyl-CoA + NADP(+)
REACT:R-HSA-9700701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T-type VDCC bind T-type VDCC blockers (Homo sapiens)
REACT:R-SCE-4086083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of ING2 with SUMO1 (Saccharomyces cerevisiae)
RHEA:68608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isatin + NADPH = 3-hydroxyindolin-2-one + NADP(+)
RHEA:25993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-epi-isozizaene + diphosphate
GO:0050440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methylcitrate oxaloacetate-lyase activity
GO:0050440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylcitrate synthetase activity
GO:0050440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)
GO:0050440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylcitrate synthase activity
GO:0050440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MCS activity
GO:0050440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylcitrate synthase activity
RHEA:71244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + hypotaurine(out) + 2 Na(+)(out) => chloride(in) + hypotaurine(in) + 2 Na(+)(in)
GO:0047351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine-triphosphate guanylyltransferase activity
GO:0047351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP guanylyltransferase activity
GO:0047351	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GTP:GTP guanylyltransferase activity
REACT:R-XTR-8964340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq-BTK complex dissociates to Active BTK and Gq (Xenopus tropicalis)
REACT:R-HSA-1839091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
RHEA:31130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-methylgallate + O2 <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol
RHEA:22304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + keto-D-fructose = 5-dehydro-D-fructose + a ubiquinol
RHEA:22304	skos:prefLabel	"fructose 5-dehydrogenase"
RHEA:22304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructose 5-dehydrogenase"
RHEA:22304	skos:altLabel	"D-fructose dehydrogenase"
REACT:R-HSA-169919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of NA (Homo sapiens)
REACT:R-DRE-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Danio rerio)
REACT:R-CFA-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Canis familiaris)
REACT:R-BTA-451366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38MAPK by DSCAM (Bos taurus)
REACT:R-GGA-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Gallus gallus)
REACT:R-SPO-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Schizosaccharomyces pombe)
REACT:R-CEL-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Caenorhabditis elegans)
RHEA:33459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + zymosterone = NADP(+) + zymosterol
REACT:R-SSC-5694442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH2,3 bind GRIA1 (Sus scrofa)
RHEA:72232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) => chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)
RHEA:26242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate => diphosphate + elisabethatriene
RHEA:52850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine
REACT:R-SCE-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Saccharomyces cerevisiae)
REACT:R-SSC-2022887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 N-deacetylates GlcNAc residues in heparan (Sus scrofa)
REACT:R-MMU-5686642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)
REACT:R-RNO-192042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Rattus norvegicus)
REACT:R-CFA-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Canis familiaris)
RHEA:40821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-HSA-1655842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P hydrolyzes SREBP1A,1C,2 (Homo sapiens)
REACT:R-DME-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Drosophila melanogaster)
REACT:R-MMU-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Mus musculus)
RHEA:71869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate(in) => glycodeoxycholate(out)
RHEA:12641	skos:altLabel	"alphaKG reductase"
RHEA:12641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH
RHEA:12641	skos:altLabel	"phosphoglyceric acid dehydrogenase"
RHEA:12641	skos:altLabel	"glycerate-1,3-phosphate dehydrogenase"
RHEA:12641	skos:prefLabel	"phosphoglycerate dehydrogenase"
RHEA:12641	skos:altLabel	"D-3-phosphoglycerate dehydrogenase"
RHEA:12641	skos:altLabel	"phosphoglycerate oxidoreductase"
RHEA:12641	skos:altLabel	"alpha-phosphoglycerate dehydrogenase"
RHEA:12641	skos:altLabel	"3-phosphoglycerate dehydrogenase"
RHEA:12641	skos:altLabel	"PGDH"
RHEA:12641	skos:altLabel	"3-phosphoglyceric acid dehydrogenase"
RHEA:12641	skos:altLabel	"glycerate 3-phosphate dehydrogenase"
RHEA:12641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglycerate dehydrogenase"
RHEA:12641	skos:altLabel	"3PHP reductase"
REACT:R-PFA-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Plasmodium falciparum)
REACT:R-MMU-9013021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOB (Mus musculus)
RHEA:32825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(out) => phosphate(in)
REACT:R-RNO-6805740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 methylates TP53 (Rattus norvegicus)
REACT:R-CFA-5634100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 dissociates from RXRA:PPARD:atRA (Canis familiaris)
REACT:R-DRE-6792863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PP2R5C dephosphorylates MDM2 (Danio rerio)
REACT:R-DDI-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Dictyostelium discoideum)
REACT:R-CEL-173725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C9 binds C5b:C6:C7:C8 (Caenorhabditis elegans)
GO:0035486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine/cytosine mispair binding
GO:0035486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C/C mispair binding
RHEA:15828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AZD1979 + H2O <=> AZD1979 oxetane hydrolysis product + H(+)
REACT:R-BTA-622325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
RHEA:49671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NAD(+)
REACT:R-DRE-2213246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of CLIP from MHC II (Danio rerio)
REACT:R-XTR-114558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate Gq (Xenopus tropicalis)
EC:1.1.1.46	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arabinose 1-dehydrogenase"
EC:1.1.1.46	skos:prefLabel	"L-arabinose 1-dehydrogenase"
RHEA:43523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-5-(dihydroxymethyl)furan + O2 <=> 2,5-dicarboxyfuran + H(+) + H2O2
REACT:R-DRE-5651773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds POLB at long-patch BER site (Danio rerio)
REACT:R-MMU-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
REACT:R-SCE-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Saccharomyces cerevisiae)
GO:0051700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructosyl-amino acid oxidase activity
GO:0051700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAOD activity
REACT:R-HSA-5672961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates inactive RAFs (Homo sapiens)
REACT:R-HSA-180855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Vpr to the mitochondria (Homo sapiens)
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diisopropylfluorophosphonate dehalogenase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diisopropyl-fluorophosphatase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OPA anhydrase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	organophosphate acid anhydrase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diisopropylphosphofluoridase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	somanase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dialkylfluorophosphatase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diisopropyl-fluorophosphate fluorohydrolase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	organophosphorus acid anhydrolase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diisopropyl phosphorofluoridate hydrolase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tabunase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OPAA activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopropylphosphorofluoridase activity
GO:0047862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DFPase activity
REACT:R-SCE-425822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Saccharomyces cerevisiae)
RHEA:46175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoate + CoA <=> AMP + butanoyl-CoA + diphosphate
REACT:R-HSA-1855155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol (Homo sapiens)
GO:0018529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrilotriacetate monooxygenase activity
REACT:R-HSA-5244397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface (Homo sapiens)
REACT:R-SSC-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Sus scrofa)
REACT:R-MMU-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Mus musculus)
REACT:R-SCE-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Saccharomyces cerevisiae)
RHEA:51277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate
RHEA:25775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparagine + O2 <=> (2S,3S)-3-hydroxyasparagine + CO2 + succinate
RHEA:17616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + scyllo-inositol <=> H(+) + NADH + scyllo-inosose
RHEA:46333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate, water dikinase] + ADP <=> [pyruvate, water dikinase]-phosphate + AMP + H(+)
REACT:R-DRE-2213236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Danio rerio)
REACT:R-CFA-75244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL binds FAS Receptor (Canis familiaris)
RHEA:61416	skos:prefLabel	"(+)-cis,trans-nepetalactol synthase"
RHEA:61416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-cis,trans-nepetalactol synthase"
RHEA:61416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol = cis-trans-nepetalactol
EC:2.4.2.4	skos:altLabel	"pyrimidine phosphorylase"
EC:2.4.2.4	skos:prefLabel	"thymidine phosphorylase"
EC:2.4.2.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thymidine phosphorylase"
GO:0052679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"terpentetriene synthase"
GO:0052679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming) activity
GO:0052679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terpentetriene synthase activity
GO:0052679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terpentedienyl diphosphate = diphosphate + terpentetriene
GO:0052679	skos:prefLabel	"terpentetriene synthase"
REACT:R-BTA-420584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin 3 trans heterodimer interaction (Bos taurus)
RHEA:10533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine => D-glyceraldehyde 3-phosphate + H2O + L-tryptophan
REACT:R-RNO-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)
REACT:R-HSA-6798020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the BTG2 gene (Homo sapiens)
RHEA:51851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-methylmenaquinone-6 + succinate <=> 8-methylmenaquinol-6 + fumarate
REACT:R-BTA-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Bos taurus)
RHEA:55340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA
RHEA:43298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O
REACT:R-HSA-9635936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF4 binds the CEBPB gene (Homo sapiens)
REACT:R-BTA-3249378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING recruits TBK1 and STAT6 (Bos taurus)
RHEA:61872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-GGA-6811431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Gallus gallus)
REACT:R-BTA-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Bos taurus)
REACT:R-XTR-9731924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds EDNs (Xenopus tropicalis)
REACT:R-DRE-8854981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 in the RET complex is phosphorylated (Danio rerio)
RHEA:45685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-dodecanoyl-sphing-4-enine-1-phosphate(in) => N-dodecanoyl-sphing-4-enine-1-phosphate(out)
REACT:R-XTR-8853762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET dimerizes (Xenopus tropicalis)
RHEA:45128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)
RHEA:46326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-4,17-dien-22-oyl-CoA + AH2 => 3-oxochol-4-en-22-oyl-CoA + A
REACT:R-RNO-391939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP receptor can bind thromboxane (Rattus norvegicus)
REACT:R-SSC-2160932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 binds phosphorylated PARD6A (Sus scrofa)
REACT:R-BTA-879201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bcl-2 and Bcl-XL bind NLRP1 (Bos taurus)
REACT:R-MMU-140216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PMAIP1 (NOXA) to mitochondria (Mus musculus)
RHEA:16242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an NDP-alpha-D-glucose + D-fructose => a ribonucleoside 5'-diphosphate + H(+) + sucrose
REACT:R-BTA-2179276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 monoubiquitinates SMAD3 (Bos taurus)
REACT:R-RNO-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Rattus norvegicus)
REACT:R-RNO-5693580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD52 with the RPA complex at resected DNA DSBs (Rattus norvegicus)
REACT:R-BTA-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Bos taurus)
REACT:R-DRE-5649701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Danio rerio)
REACT:R-BTA-139897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAD displaces tBID from BCL-2 sequestration (Bos taurus)
REACT:R-HSA-6799761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds PPP1R13L (Homo sapiens)
RHEA:30902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP
REACT:R-CFA-9691566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 binds nicorandil (Canis familiaris)
RHEA:51507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose <=> a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP
RHEA:19640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-nopaline + H2O + NADP(+) <=> 2-oxoglutarate + H(+) + L-arginine + NADPH
RHEA:68076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP
REACT:R-HSA-3262512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Homo sapiens)
REACT:R-SSC-8850777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK14 (Sus scrofa)
REACT:R-SSC-422048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acyl Ghrelin and C-Ghrelin are secreted (Sus scrofa)
RHEA:35183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxythiophene-2-carbonyl-CoA + H2O = 4-carboxy-2-thioxobutanoyl-CoA
GO:0036431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:dCMP phosphotransferase activity
GO:0036431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP kinase activity
RHEA:46566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+) => acetyl-CoA + apo-[ACP]
RHEA:16796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine <=> (R)-4'-phosphopantetheine + CO2
RHEA:16790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + O2 => a 2-oxocarboxylate + H2O2
RHEA:53464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate
RHEA:25807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermine <=> 3-aminopropanal + H2O2 + spermidine
REACT:R-DRE-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Danio rerio)
RHEA:41081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-sn-glycerol + ATP
REACT:R-DME-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Drosophila melanogaster)
RHEA:57688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[corrinoid adenosyltransferase] + cob(II)inamide = cob(II)inamide-[corrinoid adenosyltransferase]
REACT:R-DRE-6785178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Danio rerio)
RHEA:12699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dGDP => ATP + dGMP
RHEA:24329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydrofolate + ATP + formate => 10-formyldihydrofolate + ADP + phosphate
RHEA:13099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-[ACP] + H2O => a (3R)-hydroxyacyl-[ACP]
REACT:R-CFA-2473151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister centromeres (Canis familiaris)
GO:0050597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxane 10b-hydroxylase activity
GO:0050597	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-alpha-taxadienol-10-beta-hydroxylase activity
GO:0050597	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)
GO:0050597	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxane 10beta-hydroxylase activity
GO:0050597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxane 10-beta-hydroxylase activity
REACT:R-CFA-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Canis familiaris)
RHEA:46585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] => 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-3295580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPM4,5 transport extracellular Na+ to cytosol (Gallus gallus)
REACT:R-HSA-381496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the IGF:IGFBP3:ALS complex (Homo sapiens)
REACT:R-DME-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)
REACT:R-SSC-9014812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBOs bind keratan sulfate (Sus scrofa)
RHEA:59749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]
RHEA:50884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate
RHEA:68464	skos:prefLabel	"branched primary-alkylsulfatase"
RHEA:68464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"branched primary-alkylsulfatase"
RHEA:68464	skos:altLabel	"type III branched primary-alkylsulfatase"
RHEA:68464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-butyloctyl sulfate + H2O = 2-butyloctan-1-ol + H(+) + sulfate
REACT:R-GGA-76052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIA To type 1 Promoter (Gallus gallus)
RHEA:29661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine(out) => O-acetyl-L-serine(in)
REACT:R-CFA-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Canis familiaris)
REACT:R-CFA-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Canis familiaris)
RHEA:37840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-429415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to integrin alphaIIb beta3 (Canis familiaris)
EC:2.7.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucokinase"
EC:2.7.1.2	skos:altLabel	"glucose kinase"
EC:2.7.1.2	skos:prefLabel	"glucokinase"
RHEA:66115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-tyrosine <=> (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate
REACT:R-RNO-4332236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL neddylates TGFBR2 (Rattus norvegicus)
RHEA:65281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate => 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)
REACT:R-HSA-508162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Homo sapiens)
REACT:R-CEL-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)
RHEA:60339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:20866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 1-phosphate + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + phosphate
RHEA:61459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chlorotetracycline + H(+) + NADPH + O2 <=> (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)
RHEA:72881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + phosphonoacetaldehyde => (1R)-(2-amino-1-hydroxyethyl)phosphonate
REACT:R-SSC-8932355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades Ub-NFE2L2 (Sus scrofa)
RHEA:66744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-aspartate(in) = ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate
RHEA:35814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (-)-medicarpin + H2O
RHEA:14476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) <=> a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH
REACT:R-HSA-6804596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1:CYCS binds APIP (Homo sapiens)
RHEA:19355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + glycine => glycocholate + H2O
RHEA:49287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP <=> CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate
REACT:R-RNO-173545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Rattus norvegicus)
GO:0016971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavin-linked sulfhydryl oxidase activity
REACT:R-SSC-5693549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Sus scrofa)
REACT:R-GGA-170835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Gallus gallus)
RHEA:62438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-arabinonate + H2O => L-lyxonate
RHEA:60166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine => a guanosine in RNA + S-adenosyl-L-methionine
REACT:R-XTR-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Xenopus tropicalis)
RHEA:28139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + streptothricin F => streptothricin F acid
REACT:R-HSA-9623384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-agonists bind ADRA1A,B,D (Homo sapiens)
RHEA:23917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + UDP-alpha-D-glucuronate => CO2 + UDP-alpha-D-xylose
REACT:R-DME-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Drosophila melanogaster)
RHEA:36739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptadecasphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine
GO:0047653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoin racemase activity
RHEA:69914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(out) + 2 Na(+)(out) <=> adenosine(in) + 2 Na(+)(in)
RHEA:40600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
RHEA:39722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate <=> 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:58878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-SSC-8877941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SMAD1 in the nucleus (Sus scrofa)
RHEA:15328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + CoA
REACT:R-BTA-1472121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of p-KIT on Y900 by Src kinases (Bos taurus)
REACT:R-DRE-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Danio rerio)
REACT:R-DRE-6804741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 forms homo- or heterodimers (Danio rerio)
GO:0042813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	frizzled receptor activity
GO:0042813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wnt receptor activity
GO:0042813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	frizzled-2 receptor activity
GO:0042813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wnt-activated receptor activity
REACT:R-DRE-109278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Danio rerio)
EC:3.4.17.19	skos:altLabel	"carboxypeptidase 1"
EC:3.4.17.19	skos:prefLabel	"carboxypeptidase Taq"
EC:3.4.17.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxypeptidase Taq"
REACT:R-HSA-420265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind IAPP(34-70) (Homo sapiens)
REACT:R-DRE-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Danio rerio)
REACT:R-RNO-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Rattus norvegicus)
REACT:R-CEL-5671702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP1G2 binds HGS and CHMP2A (Caenorhabditis elegans)
REACT:R-BTA-389381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gads binds CD28 (Bos taurus)
RHEA:13777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribose-5-phosphate--ammonia ligase"
RHEA:13777	skos:altLabel	"5-phosphoribosylamine synthetase"
RHEA:13777	skos:prefLabel	"ribose-5-phosphate--ammonia ligase"
RHEA:13777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate + NH4(+) = 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate
RHEA:13777	skos:altLabel	"ribose 5-phosphate aminotransferase"
REACT:R-CFA-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)
REACT:R-DDI-168412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP elicits a NOD2 response (Dictyostelium discoideum)
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSC
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidosqualene--lanosterol cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-epoxysqualene lanosterol cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-oxidosqualene-lanosterol cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol synthase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidosqualene:lanosterol cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	squalene epoxidase-cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene 2,3-epoxide:lanosterol cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lanosterol 2,3-oxidosqualene cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidosqualene-lanosterol cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-epoxysqualene--lanosterol cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene-2,3-oxide-lanosterol cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2,3-oxidosqualene sterol cyclase activity
GO:0000250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-epoxysqualene-lanosterol cyclase activity
REACT:R-CFA-8852580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clusterin binds C5b-C7, C8, C9 (Canis familiaris)
REACT:R-DRE-5676595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAFs bind RANK:RANKL (Danio rerio)
REACT:R-XTR-2172678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates histone H4K20me1 (Xenopus tropicalis)
RHEA:56661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
GO:0015545	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bicyclomycin/sulfathiazole:hydrogen antiporter activity
GO:0015545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bicyclomycin transmembrane transporter activity
GO:0015545	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bicyclomycin transporter activity
EC:3.1.24.-	skos:prefLabel	"Site specific endodeoxyribonucleases: cleavage is not sequence specific"
EC:3.1.24.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Site specific endodeoxyribonucleases: cleavage is not sequence specific"
REACT:R-RNO-8870352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Rattus norvegicus)
RHEA:17165	skos:prefLabel	"galactose-1-phosphate thymidylyltransferase"
RHEA:17165	skos:altLabel	"dTDP-galactose diphosphorylase"
RHEA:17165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactose-1-phosphate thymidylyltransferase"
RHEA:17165	skos:altLabel	"dTDP-galactose pyrophosphorylase"
RHEA:17165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-D-galactose
REACT:R-DME-2022860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Drosophila melanogaster)
RHEA:31107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + O2 = (2-hydroxyphenyl)acetate + CO2
REACT:R-XTR-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Xenopus tropicalis)
RHEA:58557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate II + H2O => (16S)-deshydroxymethyl-stemmadenine + formate
REACT:R-SSC-8950179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B translocates from the cytosol to the extracellular region (Sus scrofa)
REACT:R-DRE-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Danio rerio)
REACT:R-HSA-9618004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO:SMAD complex binds CDKN1A gene promoter (Homo sapiens)
REACT:R-RNO-8944255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VII (Rattus norvegicus)
RHEA:67887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + dopamine <=> adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)
REACT:R-SCE-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)
REACT:R-BTA-202713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD84 homodimerises (Bos taurus)
RHEA:32225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + NADH + phosphate => (6S)-NADHX + ADP
REACT:R-HSA-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Homo sapiens)
RHEA:33659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-tetracosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)
RHEA:72179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauro-beta-muricholate(out) = 2 Na(+)(in) + tauro-beta-muricholate(in)
RHEA:62271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-3-methylbutyrate + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH
REACT:R-CFA-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Canis familiaris)
REACT:R-XTR-114352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of tBID by BCL-2 (Xenopus tropicalis)
RHEA:30048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetaldehyde + H2O + NAD(+) => chloroacetate + 2 H(+) + NADH
RHEA:56514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O
RHEA:44374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide => Cr(6+) + 2 NADH + O2
RHEA:18456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O <=> [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate
RHEA:72943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + pyruvate(out) = 2 Na(+)(in) + pyruvate(in)
RHEA:43136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine
RHEA:43136	skos:prefLabel	"tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase"
RHEA:43136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase"
REACT:R-HSA-193060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)
REACT:R-DME-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Drosophila melanogaster)
RHEA:59299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylglycine + 2 L-ascorbate + O2 <=> an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical
REACT:R-DRE-9624526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Danio rerio)
REACT:R-HSA-9703437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 fusion dimers autophosphorylate (Homo sapiens)
REACT:R-DDI-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Dictyostelium discoideum)
RHEA:16463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + urate(out) => ATP + H2O + urate(in)
RHEA:21040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:21040	skos:altLabel	"carbon-monoxide dehydrogenase (ferredoxin)"
RHEA:21040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anaerobic carbon-monoxide dehydrogenase"
RHEA:21040	skos:prefLabel	"anaerobic carbon-monoxide dehydrogenase"
RHEA:21040	skos:altLabel	"Ni-CODH"
RHEA:33991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-copaene synthase"
RHEA:33991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = alpha-copaene + diphosphate
RHEA:33991	skos:prefLabel	"alpha-copaene synthase"
GO:0103101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity
RHEA:54628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dodecanoyl-CoA + O2 = 2-hydroxydodecanoyl-CoA + CO2 + succinate
REACT:R-DDI-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Dictyostelium discoideum)
REACT:R-CEL-374664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of Ezrin (Caenorhabditis elegans)
RHEA:64327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (11Z)-octadecenoate + CoA
RHEA:27443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + H(+) + NADH => NAD(+) + xylitol
REACT:R-HSA-3928600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ITSN1 (Homo sapiens)
REACT:R-HSA-8848395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL18:IL18R1 binds IL18RAP (Homo sapiens)
REACT:R-XTR-374686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 interaction with Integrins (Xenopus tropicalis)
RHEA:15769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)
RHEA:47857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a (d18:1(4E)) + H2O => ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate
REACT:R-GGA-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Gallus gallus)
RHEA:11987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + progesterone <=> A + H2O + testosterone acetate
REACT:R-BTA-8939688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) complex binds RUNX2 (Bos taurus)
REACT:R-CFA-5694417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Canis familiaris)
REACT:R-CFA-141159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-mediated dimerization of procaspase-8 (Canis familiaris)
REACT:R-SCE-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Saccharomyces cerevisiae)
GO:0038122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANTES receptor activity
GO:0038122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small inducible cytokine A5 receptor activity
GO:0038122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCL5 receptor activity
GO:0038122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-C motif chemokine 5 receptor activity
REACT:R-XTR-427645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A3 cotransports Pi, 2Na+ (Xenopus tropicalis)
REACT:R-SCE-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Saccharomyces cerevisiae)
RHEA:28526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + crotonobetainyl-CoA = (R)-carnitinyl-CoA + crotonobetaine
RHEA:72099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-acetyl-(R)-carnitine(out) = Na(+)(in) + O-acetyl-(R)-carnitine(in)
RHEA:71461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Leu-L-Met-NH2 + substance P(1-9) => H2O + substance P
REACT:R-XTR-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)
RHEA:61207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal <=> H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]
RHEA:56910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + thebaine => (7S)-O-acetylsalutaridinol
REACT:R-HSA-432110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Homo sapiens)
REACT:R-DDI-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Dictyostelium discoideum)
REACT:R-MMU-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Mus musculus)
REACT:R-SSC-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Sus scrofa)
REACT:R-SSC-1254386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 forms a complex with estrogen receptor ESR1 (Sus scrofa)
RHEA:52712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + H2O = 2-deoxy-D-ribose 5-phosphate + thymine
REACT:R-MMU-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Mus musculus)
REACT:R-DRE-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Danio rerio)
REACT:R-MMU-8987070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Mus musculus)
REACT:R-DRE-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Danio rerio)
REACT:R-DRE-3965447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein subunits dissociate from WNT:FZD complex (Danio rerio)
REACT:R-DME-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Drosophila melanogaster)
RHEA:66693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-rhamnose + L-arginyl-[protein] => dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]
REACT:R-CFA-75879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Canis familiaris)
REACT:R-HSA-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)
RHEA:15938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + NADP(+) => an aldehyde + H(+) + NADPH
RHEA:68187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty acyl-CoA + H2O <=> a medium chain fatty acid + CoA + H(+)
RHEA:10295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-glucosamine 6-phosphate <=> CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate
REACT:R-BTA-417858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y14 receptor can bind to UDP-glucose (Bos taurus)
RHEA:38579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dammarenediol 12-hydroxylase"
RHEA:38579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:38579	skos:prefLabel	"dammarenediol 12-hydroxylase"
RHEA:38579	skos:altLabel	"CYP716A47"
RHEA:38579	skos:altLabel	"protopanaxadiol synthase"
RHEA:20119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-rhamnulose 1-phosphate => ATP + L-rhamnulose
REACT:R-SSC-374248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR3 binds ligands CXCL9 to 11 (Sus scrofa)
REACT:R-HSA-9667761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region (Homo sapiens)
REACT:R-HSA-190693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GJB1 (Cx32) (Homo sapiens)
RHEA:39573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-BTA-9604767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)
REACT:R-RNO-5691439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRISC complex deubiquitinates NLRP3 (Rattus norvegicus)
REACT:R-XTR-749448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Xenopus tropicalis)
REACT:R-HSA-2426530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins:Nidogens binds HSPG2 (Homo sapiens)
RHEA:67262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hept-2-enoate + 2 H(+) + NADH => (E)-hept-2-enal + H2O + NAD(+)
REACT:R-CFA-1433501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other adapter proteins with p-KIT (Canis familiaris)
GO:0102521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-4-demethylwyosine synthase activity
REACT:R-DRE-1482892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Danio rerio)
REACT:R-BTA-9026408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Bos taurus)
REACT:R-CFA-2213236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Canis familiaris)
REACT:R-SPO-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Schizosaccharomyces pombe)
REACT:R-DDI-8950181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y693-STAT4 dimer translocates to the nucleus (Dictyostelium discoideum)
RHEA:68423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-(homo)3aconitate + H2O <=> (2R,3S)-iso(homo)3citrate
REACT:R-MMU-9756138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Mus musculus)
REACT:R-DRE-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Danio rerio)
RHEA:15388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine <=> 3-cyano-L-alanine + H2O
REACT:R-HSA-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Homo sapiens)
RHEA:21698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine
REACT:R-DRE-3769447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex deacetylate histones (Danio rerio)
REACT:R-RNO-8931858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Rattus norvegicus)
RHEA:41242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 <=> N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine
REACT:R-SSC-158357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIIa binds SERPING1 (Sus scrofa)
REACT:R-MMU-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Mus musculus)
REACT:R-BTA-165182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of complexed TSC2 by PKB (Bos taurus)
REACT:R-RNO-8875817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates STAT3 (Rattus norvegicus)
RHEA:33926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)
REACT:R-DME-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Drosophila melanogaster)
REACT:R-HSA-191636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cx43 by c-src (Homo sapiens)
RHEA:19196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-13,14-dihydroretinol <=> AH2 + all-trans-retinol
RHEA:43830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine
GO:0043533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,3,4,5 tetrakisphosphate binding
GO:0043533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP4 binding
GO:0043533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	InsP4 binding
REACT:R-RNO-2168038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XV restin release (Rattus norvegicus)
RHEA:17793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-tRNA(Thr) = H(+) + L-alanine + tRNA(Thr)
REACT:R-SPO-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Schizosaccharomyces pombe)
GO:0051765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol tetrakisphosphate kinase activity
RHEA:20317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NADP(+) = 1-pyrroline-2-carboxylate + H(+) + NADPH
RHEA:69249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sinigrin => (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)
REACT:R-XTR-9748996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers cleave AZA to 6MP (Xenopus tropicalis)
GO:0036204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-ol hydroxylase activity
RHEA:48008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salicyloyl-CoA 5-hydroxylase"
RHEA:48008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-CoA + H(+) + NADH + O2 = 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)
RHEA:48008	skos:prefLabel	"salicyloyl-CoA 5-hydroxylase"
REACT:R-MMU-2466106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BGN binds Collagen types I, VI, (IX) (Mus musculus)
RHEA:29627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltohexaose + beta-maltose = alpha-maltoheptaose + beta-D-glucose
RHEA:21339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pyridoxal <=> 4-pyridoxolactone + H(+) + NADH
REACT:R-DME-5578965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A binds AGO2:miRNA (Drosophila melanogaster)
RHEA:39246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)
RHEA:48586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 lipoxin A4 => 2 H2O + 2 leukotriene A4 + O2
GO:0047989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxybutyrate-dimer hydrolase activity
GO:0047989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity
GO:0047989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-(-)-3-hydroxybutyrate-dimer hydrolase activity
REACT:R-CEL-416683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA3E binds to PLXND1 (Caenorhabditis elegans)
RHEA:50707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + NAD(+) <=> H(+) + NADH + propanal
REACT:R-CFA-8863718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGFG1 binds VAMP7 (Canis familiaris)
RHEA:12237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nicotinate => 6-hydroxynicotinate + H(+) + NADPH
REACT:R-GGA-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Gallus gallus)
RHEA:30725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 2 ATP + H2O + hydroxylamine => A + 2 ADP + H(+) + NH4(+) + 2 phosphate
RHEA:68045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-CFA-5683385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of BRCA1-A complex at DNA DSBs (Canis familiaris)
REACT:R-RNO-2105001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from DS (Rattus norvegicus)
GO:0140789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone phosphatase activity
REACT:R-DRE-1236398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds NRGs or EGF-like ligands (Danio rerio)
REACT:R-CFA-5358336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB forms mixed disulphides with Hh precursors (Canis familiaris)
REACT:R-HSA-9705299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 6 binds KPNA2 (Homo sapiens)
REACT:R-HSA-2033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)
REACT:R-HSA-9769143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 translocates to the nucleus (Homo sapiens)
REACT:R-GGA-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)
RHEA:28883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-threonine(in) = H(+)(out) + L-threonine(out)
RHEA:44550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-9033509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5L (Gallus gallus)
REACT:R-CEL-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)
REACT:R-HSA-5666088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP recruits DAIPH2-3 to endosomes (Homo sapiens)
RHEA:44266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA => eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA
GO:0034921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity
RHEA:40349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dodecanedioyl-CoA => 3-oxotetradecanedioyl-CoA + CoA
RHEA:13511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP
REACT:R-RNO-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Rattus norvegicus)
RHEA:23805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosamine 1-phosphate => N-acetyl-D-glucosamine 6-phosphate
RHEA:60771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2-oxoglutarate + gibberellin A12 + 3 O2 <=> 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate
REACT:R-HSA-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)
RHEA:10960	skos:altLabel	"lactic acid racemase"
RHEA:10960	skos:altLabel	"lacticoracemase"
RHEA:10960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate = (R)-lactate
RHEA:10960	skos:altLabel	"hydroxyacid racemase"
RHEA:10960	skos:prefLabel	"lactate racemase"
RHEA:10960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactate racemase"
REACT:R-MMU-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Mus musculus)
RHEA:28000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphate + thiamine phosphate => H2O + thiamine diphosphate
RHEA:44377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) => a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)
REACT:R-HSA-8954199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)
REACT:R-BTA-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)
RHEA:41370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
REACT:R-DRE-5654510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 binds SPRED1/2 (Danio rerio)
REACT:R-MMU-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Mus musculus)
RHEA:55794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-butanone + H2O + NAD(+) => butan-2-one + H(+) + NADH + O2
GO:0140948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-monomethyltransferase activity (H3-K9 specific)
GO:0140948	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K9 methylation
GO:0140948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 monomethyltransferase activity
GO:0140948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 monomethylase activity
GO:0140948	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K9 methylation
RHEA:45059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxynogalonate + O2 <=> H(+) + H2O + nogalonate
REACT:R-MMU-8986985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Mus musculus)
RHEA:53745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-tRNA(Ala) + H2O => glycine + H(+) + tRNA(Ala)
RHEA:38813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
REACT:R-DME-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Drosophila melanogaster)
REACT:R-CEL-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Caenorhabditis elegans)
RHEA:63829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + vanillin => pyruvate + vanillylamine
RHEA:42172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoyl-CoA + AH2 + O2 = (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O
GO:1990136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleate 9S-lipoxygenase activity
GO:1990136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	9-lipoxygenase activity
GO:1990136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	9S-lipoxygenase activity
GO:1990136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate 9-lipoxygenase activity
GO:1990136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleate:oxygen 9S-oxidoreductase activity
GO:0018576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol 1,2-dioxygenase activity
GO:0018576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catechol 1,2-oxygenase activity
GO:0018576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catechol:oxygen 1,2-oxidoreductase activity
GO:0018576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catechase activity
GO:0018576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrocatechol 1,2-dioxygenase activity
GO:0018576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catechol-oxygen 1,2-oxidoreductase activity
GO:0018576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-pyrocatechase activity
GO:0018576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CD I
GO:0018576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrocatechase activity
GO:0018576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CD II
RHEA:62319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylate + UDP-alpha-D-glucose <=> 1-O-salicyl-beta-D-glucose + UDP
RHEA:10782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + H(+) + NADH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+)
EC:3.4.21.57	skos:prefLabel	"leucyl endopeptidase"
EC:3.4.21.57	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leucyl endopeptidase"
EC:3.4.21.57	skos:altLabel	"leucine-specific serine proteinase"
EC:3.4.21.57	skos:altLabel	"plant Leu-proteinase"
REACT:R-SSC-2213240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of disulphide bonds in MHC II antigens (Sus scrofa)
REACT:R-BTA-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Bos taurus)
RHEA:22265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,6-trichloropyridin-2-ol + FADH2 + O2 => 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O
REACT:R-BTA-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Bos taurus)
GO:0008761	skos:altLabel	"UDP-N-acetyl-D-glucosamine 2-epimerase"
GO:0008761	skos:altLabel	"uridine diphosphate-N-acetylglucosamine-2'-epimerase"
GO:0008761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine
GO:0008761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)"
GO:0008761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine 2-epimerase activity
GO:0008761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine 2'-epimerase activity
GO:0008761	skos:altLabel	"uridine diphospho-N-acetylglucosamine 2'-epimerase"
GO:0008761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine 2-epimerase activity
GO:0008761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc-2-epimerase activity
GO:0008761	skos:prefLabel	"UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)"
GO:0008761	skos:altLabel	"uridine diphosphoacetylglucosamine 2'-epimerase"
GO:0008761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine 2'-epimerase activity
GO:0008761	skos:altLabel	"UDP-GlcNAc-2-epimerase"
GO:0008761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate-N-acetylglucosamine-2'-epimerase activity
GO:0008761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphospho-N-acetylglucosamine 2'-epimerase activity
RHEA:23634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CO2 + NADH => D-threo-isocitrate + NAD(+)
REACT:R-DDI-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Dictyostelium discoideum)
REACT:R-XTR-5433067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Xenopus tropicalis)
REACT:R-SSC-3165230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC52A1,2,3 transport RIB from extracellular region to cytosol (Sus scrofa)
RHEA:19691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + dihydroxyacetone phosphate => L-rhamnulose 1-phosphate
REACT:R-HSA-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Homo sapiens)
REACT:R-CFA-420584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin 3 trans heterodimer interaction (Canis familiaris)
REACT:R-RNO-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)
REACT:R-RNO-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Rattus norvegicus)
RHEA:56456	skos:prefLabel	"12-epi-fischerindole U synthase"
RHEA:56456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-fischerindole U
RHEA:56456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"12-epi-fischerindole U synthase"
REACT:R-DRE-8941312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Danio rerio)
REACT:R-MMU-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Mus musculus)
REACT:R-XTR-9700120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTN and MDK bind to PTPRZ (Xenopus tropicalis)
GO:0033208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity
GO:0033208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity
GO:0033208	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Sda beta 1,4GalNAc transferase
REACT:R-BTA-202510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1-TAB2 complex (Bos taurus)
RHEA:20931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-dithiol + a quinone <=> [DsbA protein]-disulfide + a quinol
RHEA:62409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine => 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine
RHEA:60565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose + ATP => 2-deoxy-D-glucose 6-phosphate + ADP + H(+)
REACT:R-CFA-8871227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA4 (Canis familiaris)
REACT:R-GGA-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Gallus gallus)
REACT:R-SCE-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Saccharomyces cerevisiae)
REACT:R-SSC-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Sus scrofa)
RHEA:64174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate => L-altrarate
REACT:R-SSC-9727607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ binds sacubitrilat (Sus scrofa)
REACT:R-CFA-8851979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL9 binds immune cell surfaces (Canis familiaris)
REACT:R-SPO-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Schizosaccharomyces pombe)
RHEA:24137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a primary amine => a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)
RHEA:20711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + erythritol <=> ADP + D-erythritol 4-phosphate + H(+)
RHEA:46335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Drosophila melanogaster)
RHEA:52888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-phenylhydroxylamine + NADP(+) = H(+) + NADPH + nitrosobenzene
REACT:R-PFA-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Plasmodium falciparum)
REACT:R-CFA-1676164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Canis familiaris)
REACT:R-BTA-6811423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Bos taurus)
RHEA:14488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-juneol + diphosphate
REACT:R-HSA-166041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of LPS onto TLR4 (Homo sapiens)
REACT:R-CFA-8850945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates PTEN (Canis familiaris)
REACT:R-HSA-3928602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF binds EPHA (Homo sapiens)
REACT:R-HSA-6789092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide anion from oxygen (Homo sapiens)
RHEA:69468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose = L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose
RHEA:21951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formamide + H2O <=> formate + NH4(+)
REACT:R-CFA-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Canis familiaris)
GO:0018594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tert-butanol 2-monooxygenase activity
GO:0018594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tert-butyl alcohol 2-monooxygenase activity
REACT:R-MMU-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Mus musculus)
REACT:R-BTA-1454791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP7, MMP9 bind CD44 (Bos taurus)
REACT:R-RNO-9758090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
RHEA:61086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + CO2 + succinate => (2S)-naringenin + 2-oxoglutarate + O2
RHEA:47579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) <=> CMP + ganglioside GD1c (d18:1(4E)) + H(+)
RHEA:66166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-butanoylserotonin => butanoyl-CoA + serotonin
REACT:R-CFA-5687090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6 phosphorylates NCOA3 (Canis familiaris)
RHEA:66068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-leucine
REACT:R-DRE-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Danio rerio)
GO:1905030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage gated ion channel activity involved in regulation of post-synaptic membrane potential
GO:1905030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential
GO:1905030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential
GO:1905030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential
GO:1905030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage gated ion channel activity involved in regulation of postsynaptic membrane potential
GO:1905030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
REACT:R-HSA-9614185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
GO:0008483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transaminases"
GO:0008483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminotransferase activity
GO:0008483	skos:prefLabel	"Transaminases"
GO:0008483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transaminase activity
GO:0008483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transamination of MOB to methionine (Homo sapiens)
REACT:R-DRE-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Danio rerio)
RHEA:21779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate
REACT:R-GGA-9645501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Gallus gallus)
RHEA:35555	skos:altLabel	"CYP134A1"
RHEA:35555	skos:altLabel	"cyclo-L-leucyl-L-leucyl dipeptide oxidase"
RHEA:35555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid
RHEA:35555	skos:prefLabel	"pulcherriminic acid synthase"
RHEA:35555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pulcherriminic acid synthase"
REACT:R-DRE-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Danio rerio)
RHEA:13738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an n-alkanal + NADP(+) => an alk-2-enal + H(+) + NADPH
REACT:R-BTA-9757951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)
RHEA:11458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine
RHEA:56128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dimethylallyl diphosphate + H2O + nonaflavuxanthin = AH2 + diphosphate + flavuxanthin
REACT:R-DDI-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Dictyostelium discoideum)
REACT:R-PFA-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Plasmodium falciparum)
RHEA:35901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA
REACT:R-XTR-2395818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)
REACT:R-CEL-168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
RHEA:70996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine(out) + L-glutamate(in) => L-cystine(in) + L-glutamate(out)
RHEA:11444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate
RHEA:11444	skos:prefLabel	"chondro-4-sulfatase"
RHEA:11444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chondro-4-sulfatase"
RHEA:69510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamino-1,5-lactone
RHEA:57202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glyoxal + L-arginyl-[protein]
RHEA:33237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+) => 2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2
REACT:R-SSC-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Sus scrofa)
REACT:R-DME-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Drosophila melanogaster)
GO:0016864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular isomerase activity, transposing S-S bonds
GO:0016864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular oxidoreductase activity, transposing S-S bonds
GO:0016864	skos:prefLabel	"Transposing S-S bonds"
GO:0016864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transposing S-S bonds"
REACT:R-XTR-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Xenopus tropicalis)
GO:0034798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fosfomycin 2-L-cysteine ligase activity
REACT:R-MMU-445757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1 receptor antagonist protein binds Interleukin 1 receptors (Mus musculus)
REACT:R-DRE-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Danio rerio)
RHEA:48059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> beta-D-glucosylceramide + D-galactose
REACT:R-SCE-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Saccharomyces cerevisiae)
GO:0050253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinyl palmitate hydrolyase activity
GO:0050253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinyl ester hydrolase activity
GO:0050253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinyl-palmitate palmitohydrolase activity
GO:0050253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinyl palmitate hydrolase activity
GO:0050253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinyl-palmitate esterase activity
RHEA:17551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine
REACT:R-XTR-388503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxytocin receptor bind oxytocin (Xenopus tropicalis)
REACT:R-BTA-2396079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds Plasminogen activator inhibitor- 1 (Bos taurus)
RHEA:28564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine 5'-phosphate + pyruvate => D-alanine + pyridoxal 5'-phosphate
REACT:R-BTA-8863472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAB2 binds LRP2 (Bos taurus)
RHEA:58093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)
REACT:R-MMU-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Mus musculus)
RHEA:46315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + acetyl-CoA <=> 3,22-dioxochol-4-en-24-oyl-CoA + CoA
REACT:R-SSC-1236943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigen peptide onto MHC class I molecule (Sus scrofa)
RHEA:66405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O + taurocholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)
REACT:R-HSA-5362386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Hh (Homo sapiens)
RHEA:63843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + tert-butyl hydroperoxide <=> [thioredoxin]-disulfide + H2O + tert-butanol
RHEA:16959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H(+) => 3',5'-cyclic GMP + H2O
REACT:R-HSA-5686625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAIR1 binds collagen (Homo sapiens)
REACT:R-XTR-4641147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DACT1 binds DVL2 (Xenopus tropicalis)
RHEA:53268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose = L-xylulose
REACT:R-DME-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Drosophila melanogaster)
REACT:R-CEL-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Caenorhabditis elegans)
REACT:R-HSA-9752977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTP1S and RTP2 bind underrepresented Olfactory Receptors (uORs) (Homo sapiens)
REACT:R-DRE-5688837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 deubiquitinates polyUb-PARK2 (Danio rerio)
RHEA:33808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + H(+) => 2-methoxy-4-vinylphenol + CO2
REACT:R-XTR-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Xenopus tropicalis)
RHEA:60922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2
RHEA:62265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) => hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)
REACT:R-DDI-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)
RHEA:71349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-lysine(in) + 2 Na(+)(in) => chloride(out) + L-lysine(out) + 2 Na(+)(out)
REACT:R-HSA-380905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)
RHEA:23698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + H(+) + H2O => myo-inositol + O2
RHEA:29314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + O2 + sulfoacetate <=> FMN + glyoxylate + 2 H(+) + H2O + sulfite
GO:1904288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bag6 complex binding
GO:1904288	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BAT3-TRC35-UBL4A complex binding
GO:1904288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAG6-UBL4A-TRC35 complex binding
GO:1904288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAT3 complex binding
EC:4.6.1.18	skos:altLabel	"RNase I"
EC:4.6.1.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pancreatic ribonuclease"
EC:4.6.1.18	skos:altLabel	"RNase"
EC:4.6.1.18	skos:prefLabel	"pancreatic ribonuclease"
EC:4.6.1.18	skos:altLabel	"RNase A"
EC:4.6.1.18	skos:altLabel	"ribonuclease I"
EC:4.6.1.18	skos:altLabel	"pancreatic RNase"
REACT:R-CEL-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
REACT:R-XTR-5675433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP5 dephosphorylates RAF1 S338 (Xenopus tropicalis)
REACT:R-RNO-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
GO:0043781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalt-precorrin-2 C(20)-methyltransferase activity
GO:0043781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity
GO:0043781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-factor II C20-methyltransferase activity
GO:0043781	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CbiL
GO:0043781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-factor II C20 methyltransferase activity
RHEA:65885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-hydroxy-L-kynurenine => H2O + L-glutamate + xanthurenate
REACT:R-XTR-5624129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LZTFL1 binds the BBSome and prevents its traffic to the cilium (Xenopus tropicalis)
REACT:R-SSC-9645481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIFA oligomerization (Sus scrofa)
REACT:R-SSC-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Sus scrofa)
REACT:R-HSA-9686731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis (Homo sapiens)
RHEA:70424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H2O => a carboxylate + CoA + H(+)
RHEA:34116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxynorspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine
GO:0008127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 2,4-oxygenase activity
GO:0008127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quercetinase activity
GO:0008127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quercetin:oxygen 2,3-oxidoreductase (decyclizing)
GO:0008127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 2,3-dioxygenase activity
REACT:R-RNO-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Rattus norvegicus)
REACT:R-GGA-1250380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Gallus gallus)
REACT:R-SSC-76456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-atom dealkylation of dextromethorphan (Sus scrofa)
REACT:R-RNO-419011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectins (Rattus norvegicus)
REACT:R-MMU-211988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Mus musculus)
REACT:R-RNO-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Rattus norvegicus)
REACT:R-HSA-8869606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NAR to yield NAMN (Homo sapiens)
REACT:R-MMU-448660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL31:IL31RA:JAK1 binds OSMR:JAK1 (Mus musculus)
REACT:R-MMU-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Mus musculus)
RHEA:49235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannose 6-phosphate(in) + L-histidyl-[protein]
REACT:R-DRE-176604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Danio rerio)
REACT:R-BTA-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Bos taurus)
REACT:R-RNO-9026967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 inhibitors binds VKORC1 dimer (Rattus norvegicus)
RHEA:71757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + 2-oxoheptanedioate(out) => 2-oxoglutarate(out) + 2-oxoheptanedioate(in)
RHEA:58671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyfructose + NADP(+) <=> 3-deoxyglucosone + H(+) + NADPH
REACT:R-CEL-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Caenorhabditis elegans)
REACT:R-MMU-2990842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO2 (Mus musculus)
REACT:R-SSC-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)
RHEA:32238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADPHX + ADP <=> AMP + H(+) + NADPH + phosphate
REACT:R-DRE-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Danio rerio)
REACT:R-HSA-5653878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Homo sapiens)
REACT:R-HSA-3209179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERF inhibits ETS2 expression (Homo sapiens)
REACT:R-DRE-1247922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCT transforms gGluCys to OPRO (Danio rerio)
REACT:R-DME-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Drosophila melanogaster)
RHEA:10845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + pyridoxamine => L-aspartate + pyridoxal
RHEA:23835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine + ATP <=> ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)
REACT:R-MMU-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Mus musculus)
REACT:R-RNO-159803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Rattus norvegicus)
RHEA:38577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
RHEA:27453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
REACT:R-CFA-5218814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 autophorylates (Canis familiaris)
REACT:R-DRE-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Danio rerio)
REACT:R-SPO-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)
REACT:R-GGA-2514772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Gallus gallus)
REACT:R-RNO-1678650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses Heparan sulfate chain(5) (Rattus norvegicus)
REACT:R-XTR-8936214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCY2C trimer binds GUCA2A,B (Xenopus tropicalis)
RHEA:23932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate
REACT:R-MMU-380278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Mus musculus)
EC:3.6.1.6	skos:altLabel	"nucleoside-diphosphatase"
EC:3.6.1.6	skos:prefLabel	"nucleoside diphosphate phosphatase"
EC:3.6.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside diphosphate phosphatase"
REACT:R-RNO-5693551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)
RHEA:66002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein]
REACT:R-HSA-5671707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Homo sapiens)
REACT:R-HSA-2267372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Homo sapiens)
REACT:R-BTA-8849032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS2 (Bos taurus)
REACT:R-DRE-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Danio rerio)
REACT:R-SCE-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Saccharomyces cerevisiae)
REACT:R-SSC-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)
RHEA:31680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prosolanapyrone II => H2O2 + prosolanapyrone III
REACT:R-XTR-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Xenopus tropicalis)
REACT:R-DRE-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Danio rerio)
RHEA:20538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + holo-[ACP] => (R)-4'-phosphopantetheine + apo-[ACP] + H(+)
RHEA:57911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamyl-tRNA(Gln) <=> 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP
RHEA:14386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphate + H2O => a dolichyl phosphate + H(+) + phosphate
RHEA:62485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-BTA-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Bos taurus)
REACT:R-DME-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Drosophila melanogaster)
RHEA:19934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + H2O => D-glucose + phosphate
REACT:R-SSC-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Sus scrofa)
REACT:R-HSA-400434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds fatty acids (Homo sapiens)
REACT:R-DRE-391211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trace amine-associated receptors can bind trace amines (Danio rerio)
REACT:R-GGA-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Gallus gallus)
GO:0004834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan synthetase activity
GO:0004834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan synthetase activity
GO:0004834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]
GO:0004834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine hydro-lyase (adding indoleglycerol-phosphate)
GO:0004834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan desmolase activity
GO:0004834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan synthase activity
GO:0004834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleglycerol phosphate aldolase activity
RHEA:28175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => colneleate + H2O
REACT:R-GGA-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)
REACT:R-XTR-8952996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 forms homodimers (Xenopus tropicalis)
REACT:R-DME-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Drosophila melanogaster)
REACT:R-DME-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Drosophila melanogaster)
RHEA:46797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:53527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-DME-977615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates MCP/CR1-bound C4b/C3b (Drosophila melanogaster)
REACT:R-RNO-2454081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5 oxidises 11cROL to 11cRAL (Rattus norvegicus)
REACT:R-DDI-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)
REACT:R-BTA-5654159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds PLCG1 (Bos taurus)
REACT:R-DRE-3322434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP dissociates from ub-TLE (Danio rerio)
REACT:R-RNO-352029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Rattus norvegicus)
RHEA:37418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA
GO:0098531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-activated transcription factor activity
GO:0098531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription factor activity, direct ligand regulated sequence-specific DNA binding
GO:0098531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	direct ligand regulated sequence-specific DNA binding transcription factor activity
REACT:R-GGA-397835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:Gq (active) dissociate (Gallus gallus)
RHEA:18308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-4-O-acetylneuraminate
GO:0016751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-succinyltransferase activity
REACT:R-DRE-9026780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Danio rerio)
REACT:R-RNO-5623519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP and RAB8A bind to the ciliary targeting complex (Rattus norvegicus)
RHEA:53636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine
REACT:R-DRE-9708430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 (CRM1) binds to BACH1:Hemes (Danio rerio)
RHEA:33269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+) => (S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+)
REACT:R-DDI-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)
REACT:R-SSC-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Sus scrofa)
RHEA:46609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[protein] => ADP + H(+) + O-phospho-L-threonyl-[protein]
REACT:R-HSA-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Homo sapiens)
REACT:R-XTR-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Xenopus tropicalis)
REACT:R-CFA-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Canis familiaris)
EC:3.2.1.59	skos:prefLabel	"glucan endo-1,3-alpha-glucosidase"
EC:3.2.1.59	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan endo-1,3-alpha-glucosidase"
EC:3.2.1.59	skos:altLabel	"endo-1,3-alpha-glucanase"
REACT:R-RNO-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Rattus norvegicus)
REACT:R-RNO-426209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG activation of TRPC channels (Rattus norvegicus)
REACT:R-SSC-193679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-secretase cleaves the p75NTR extracellular domain (Sus scrofa)
REACT:R-RNO-8982162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Rattus norvegicus)
RHEA:50897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O => (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate
REACT:R-GGA-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Gallus gallus)
RHEA:25441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => delta-selinene + diphosphate
REACT:R-RNO-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Rattus norvegicus)
REACT:R-RNO-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Rattus norvegicus)
RHEA:72100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-acetyl-(R)-carnitine(out) => Na(+)(in) + O-acetyl-(R)-carnitine(in)
RHEA:71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) <=> chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)
RHEA:59513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylsalicylate + L-seryl-[protein] => O-acetyl-L-seryl-[protein] + salicylate
REACT:R-HSA-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Homo sapiens)
REACT:R-GGA-4088134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates FOXM1 (Gallus gallus)
REACT:R-DME-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Drosophila melanogaster)
REACT:R-SSC-8940388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPLD1 hydrolyses GPI-anchors from proteins (Sus scrofa)
RHEA:18088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + methanophenazine <=> coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine
REACT:R-BTA-9728664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1R agonists (Bos taurus)
REACT:R-HSA-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Homo sapiens)
RHEA:12575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide + ADP + H(+) + phosphate
REACT:R-SSC-5626316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Sus scrofa)
RHEA:57224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + GTP = N(2)-(1-hydroxy-2-oxoethyl)-GTP
REACT:R-CEL-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)
REACT:R-CEL-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Caenorhabditis elegans)
REACT:R-MMU-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Mus musculus)
REACT:R-DRE-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Danio rerio)
REACT:R-CFA-6801195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3 binds BNIP3L (Canis familiaris)
REACT:R-DRE-211873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
RHEA:61930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-miconazole(out) + ADP + H(+) + phosphate => (R)-miconazole(in) + ATP + H2O
REACT:R-BTA-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Bos taurus)
REACT:R-SCE-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)
GO:0008994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnulose-1-phosphate aldolase"
GO:0008994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate
GO:0008994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnulose-phosphate aldolase activity
GO:0008994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)
GO:0008994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnulose 1-phosphate aldolase activity
GO:0008994	skos:altLabel	"L-rhamnulose 1-phosphate aldolase"
GO:0008994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnulose-1-phosphate lactaldehyde-lyase activity
GO:0008994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnulose-1-phosphate aldolase activity
GO:0008994	skos:prefLabel	"rhamnulose-1-phosphate aldolase"
GO:0008994	skos:altLabel	"L-rhamnulose-phosphate aldolase"
GO:0008994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rhamnulose phosphate aldolase activity
GO:0008994	skos:altLabel	"L-rhamnulose-1-phosphate lactaldehyde-lyase"
RHEA:44501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)
REACT:R-HSA-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Homo sapiens)
REACT:R-BTA-202394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CARMA1 to Plasma membrane (Bos taurus)
RHEA:25785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-rhamnonate => (S)-lactaldehyde + pyruvate
RHEA:41362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
RHEA:21353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)
RHEA:40172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + O2 => (2E)-dodecenoyl-CoA + H2O2
REACT:R-BTA-5607750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Bos taurus)
REACT:R-HSA-2130486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)
RHEA:12178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine => phenylethanolamine + S-adenosyl-L-methionine
REACT:R-SSC-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Sus scrofa)
RHEA:69594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + IMP => CMP + inosine
RHEA:31062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + imidazole-4-acetaldehyde + NAD(+) <=> 2 H(+) + imidazole-4-acetate + NADH
RHEA:60021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene A
RHEA:40119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate
REACT:R-XTR-8942344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 transports FOLA from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-RNO-5665727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds CDC42:GTP (Rattus norvegicus)
REACT:R-CFA-9706308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRB10 (Canis familiaris)
REACT:R-GGA-2294580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 hyperphosphorylates Condensin II complex (Gallus gallus)
REACT:R-RNO-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Rattus norvegicus)
REACT:R-DME-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Drosophila melanogaster)
GO:0050543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosatetraenoic acid binding
GO:0050543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	icosatetraenoic acid binding
REACT:R-DME-69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Drosophila melanogaster)
RHEA:31521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-butenal + 4'-apo-beta-carotenal => O2 + torulene
REACT:R-GGA-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Gallus gallus)
REACT:R-CFA-9036301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Canis familiaris)
REACT:R-MMU-1678920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR processing at low pH (Mus musculus)
RHEA:31562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactose + NAD(+) <=> H(+) + L-galactono-1,4-lactone + NADH
REACT:R-MMU-9627107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP7 (Mus musculus)
REACT:R-GGA-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Gallus gallus)
REACT:R-HSA-9710263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GZMB cleaves GSDME (Homo sapiens)
RHEA:12186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-acetoin + H(+) + NADH => (S,S)-butane-2,3-diol + NAD(+)
REACT:R-XTR-392187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated P2Y purinoceptor 12 binds G-protein Gi (Xenopus tropicalis)
RHEA:37108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(7)-methyl-GMP => N(7)-methylguanosine + phosphate
RHEA:37978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + homogentisate + phytyl diphosphate <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate
REACT:R-HSA-3371467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates HSF1 (Homo sapiens)
REACT:R-DRE-3858489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds DAAM1 (Danio rerio)
RHEA:27450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate
RHEA:41267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)-sphing-4-enine = (15Z)-tetracosenoate + sphing-4-enine
REACT:R-BTA-174157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cyclin B (Bos taurus)
RHEA:51754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-4-prenylphloroglucinol + diphosphate => a 2-acylphloroglucinol + dimethylallyl diphosphate
RHEA:39204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetracosenoyl-CoA + H(+) + NADPH => NADP(+) + tetracosanoyl-CoA
RHEA:55522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 diphosphate + nerylneryl diphosphate => dimethylallyl diphosphate + 3 isopentenyl diphosphate
REACT:R-CEL-426209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG activation of TRPC channels (Caenorhabditis elegans)
RHEA:13829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
REACT:R-MMU-5223313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Mus musculus)
GO:0018656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene 3,4-monooxygenase activity
REACT:R-RNO-1247922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCT transforms gGluCys to OPRO (Rattus norvegicus)
REACT:R-HSA-177931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Homo sapiens)
REACT:R-DDI-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Dictyostelium discoideum)
GO:0016498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuromedin K receptor activity
GO:0016498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurokinin B receptor activity
REACT:R-CFA-114354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP:Caspase-7 (Canis familiaris)
REACT:R-MMU-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Mus musculus)
REACT:R-DRE-5362427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds GPC5 (Danio rerio)
RHEA:29435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin(in) + H(+)(out) = enterobactin(out) + H(+)(in)
RHEA:43592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral
RHEA:17471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein] => a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]
REACT:R-HSA-2453876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTR:RBP:atROL binds to STRA6 receptor (Homo sapiens)
GO:0018465	skos:altLabel	"4-hydroxy-2-methoxybenzyl alcohol oxidase"
GO:0018465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-methoxybenzyl alcohol oxidase activity
GO:0018465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vanillyl-alcohol oxidase activity
GO:0018465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-methoxy-benzenemethanol + O2 = H2O2 + vanillin
GO:0018465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vanillyl-alcohol oxidase"
GO:0018465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vanillyl alcohol:oxygen oxidoreductase activity
GO:0018465	skos:prefLabel	"vanillyl-alcohol oxidase"
RHEA:48218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein]
REACT:R-BTA-389352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Vav1 to CD28 (Bos taurus)
REACT:R-CFA-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Canis familiaris)
REACT:R-CEL-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Caenorhabditis elegans)
REACT:R-DRE-174171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A with the APC/C (Danio rerio)
REACT:R-BTA-5655170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 monoubiquitinates POLH (Bos taurus)
REACT:R-BTA-9700662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Bos taurus)
REACT:R-XTR-203774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Csk with PAG (Xenopus tropicalis)
REACT:R-HSA-4086205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN (osteopontin) degradation by MMP3, MMP7 (Homo sapiens)
REACT:R-BTA-1678708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(2) (Bos taurus)
REACT:R-HSA-8932284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NFE2L2 (Homo sapiens)
REACT:R-DRE-444202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR1 binds free fatty acids (Danio rerio)
REACT:R-GGA-2130725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of MHC II:Ii clathrin coated vesicle (Gallus gallus)
GO:0008373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialyltransferase activity
RHEA:27990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose + ATP = 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)
REACT:R-HSA-9670619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ATRX does not bind DAXX (Homo sapiens)
REACT:R-DME-2130282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)
RHEA:53505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate
REACT:R-HSA-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Homo sapiens)
REACT:R-SSC-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Sus scrofa)
RHEA:55017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menthone + NADPH + O2 => 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)
RHEA:15864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ADP-2-phosphoglycerate + H2O <=> 3-ADP-glycerate + phosphate
REACT:R-MMU-2090085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan chain(1) (Mus musculus)
RHEA:29678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol(in) <=> glycerol(out)
REACT:R-SSC-9679477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFA inhibitors (Sus scrofa)
RHEA:40472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-methylpentadecanoyl-CoA + O2 => 2-methyl-(2E)-pentadecenoyl-CoA + H2O2
REACT:R-CEL-380905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serotonin loaded synaptic vesicle docking and priming (Caenorhabditis elegans)
REACT:R-CEL-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Caenorhabditis elegans)
REACT:R-SSC-5626982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF binds GNB2L1 (Sus scrofa)
RHEA:62590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzyl alcohol + CO2 => 2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+)
GO:0003896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA primase activity
GO:0003896	skos:prefLabel	"DNA primase DnaG"
GO:0003896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA primase DnaG"
REACT:R-BTA-9708558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Bos taurus)
REACT:R-MMU-8981606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin binds oxygen (Mus musculus)
REACT:R-CFA-6791227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Canis familiaris)
RHEA:49295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]
REACT:R-SCE-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Saccharomyces cerevisiae)
RHEA:48861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-HEPE + O2 => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate
RHEA:33588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
REACT:R-MMU-5654222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PLCG1 (Mus musculus)
RHEA:33773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine
REACT:R-DRE-8943780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 recruits NuRD to PTEN gene (Danio rerio)
RHEA:65652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine = a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine
REACT:R-BTA-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Bos taurus)
REACT:R-XTR-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Xenopus tropicalis)
REACT:R-RNO-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Rattus norvegicus)
RHEA:45261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracosanoate(out) => tetracosanoate(in)
REACT:R-MMU-9629470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Mus musculus)
RHEA:26099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + limonene 1,2-epoxide + NADP(+) => (4R)-limonene + H(+) + NADPH + O2
GO:0016844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	strictosidine synthetase activity
GO:0016844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	strictosidine synthase activity
GO:0016844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alpha(S)-strictosidine tryptamine-lyase activity
GO:0016844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STR activity
GO:0016844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)
REACT:R-SPO-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Schizosaccharomyces pombe)
REACT:R-CEL-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Caenorhabditis elegans)
RHEA:38963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate
GO:0036209	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	9-beta-stemod-13(17)-ene oxidase activity
GO:0036209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene oxidase activity
REACT:R-DRE-5621355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Danio rerio)
REACT:R-MMU-5229273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCN2:2,5DHBA binds Fe3+ (Mus musculus)
REACT:R-MMU-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Mus musculus)
RHEA:29954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + uridine(in) <=> H(+)(out) + uridine(out)
REACT:R-HSA-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Homo sapiens)
RHEA:65105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene D + L-prolyl-[peptidyl-carrier protein] => aculene B + holo-[peptidyl-carrier protein]
EC:2.3.2.24	skos:prefLabel	"(E3-independent) E2 ubiquitin-conjugating enzyme"
EC:2.3.2.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(E3-independent) E2 ubiquitin-conjugating enzyme"
EC:2.3.2.24	skos:altLabel	"E3-independent ubiquitin-conjugating enzyme E2"
REACT:R-CFA-199161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fc gamma receptors interact with antigen-bound IgG (Canis familiaris)
REACT:R-HSA-9759129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds the PRDX1 promoter (Homo sapiens)
REACT:R-HSA-912389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of axial/lateral elements of Synaptonemal Complex (Homo sapiens)
RHEA:54880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3R)-3-isopropenyl-6-oxoheptanoate + H(+)
RHEA:24323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:50480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]
REACT:R-GGA-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Gallus gallus)
RHEA:42749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(967) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-451508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of phospho ERK2 dimer (Gallus gallus)
REACT:R-MMU-1602374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Mus musculus)
REACT:R-CFA-203712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS associates with Caveolin-1 (Canis familiaris)
GO:0034835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-mercaptobenzothiazole monooxygenase activity
REACT:R-GGA-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Gallus gallus)
REACT:R-BTA-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Bos taurus)
REACT:R-XTR-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Xenopus tropicalis)
RHEA:37859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:29841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-L-idonate + H(+) + NADPH => L-idonate + NADP(+)
REACT:R-HSA-9664567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 KD mutants heterodimerize (Homo sapiens)
RHEA:21914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + CO2 + H2O2 => CoA + H(+) + O2 + pyruvate
REACT:R-DME-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Drosophila melanogaster)
REACT:R-HSA-5610036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GALE does not epimerise UDP-Gal to UDP-Glc (Homo sapiens)
RHEA:33265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-2161999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Canis familiaris)
REACT:R-CFA-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Canis familiaris)
RHEA:49540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate
RHEA:46028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + tetradecanoate = (2R)-hydroxytetradecanoate + H2O
REACT:R-BTA-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Bos taurus)
REACT:R-BTA-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Bos taurus)
RHEA:34976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate(in) => (R)-pantothenate(out)
RHEA:64909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + 2 H2O => CMP + 2 H(+) + 2 phosphate
REACT:R-HSA-192054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Homo sapiens)
REACT:R-CFA-9629149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves thymine glycol from damaged DNA (Canis familiaris)
EC:3.4.21.85	skos:prefLabel	"limulus clotting factor B"
EC:3.4.21.85	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limulus clotting factor B"
REACT:R-DRE-8862380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B13 binds lipid droplets (Danio rerio)
REACT:R-SCE-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Saccharomyces cerevisiae)
REACT:R-BTA-8983335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Bos taurus)
RHEA:66994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylpentanoyl-CoA + AMP + diphosphate => 3-methylpentanoate + ATP + CoA
REACT:R-SSC-8948027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial phospholipids (Sus scrofa)
REACT:R-HSA-3965446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling (Homo sapiens)
REACT:R-HSA-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Homo sapiens)
RHEA:66881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:29819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-isoleucine(out) = ADP + H(+) + L-isoleucine(in) + phosphate
RHEA:66287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tomatidine + UDP-alpha-D-glucose <=> H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP
RHEA:35461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-5-en-3-one + H(+) + NADH => cholesterol + NAD(+)
REACT:R-CEL-2990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO1 to UBA2:SAE1 (Caenorhabditis elegans)
REACT:R-BTA-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Bos taurus)
REACT:R-DRE-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Danio rerio)
REACT:R-DME-8937442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES3 hydrolyses CHEST to CHOL and LCFA(-) (Drosophila melanogaster)
RHEA:54574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pseudouridine in tRNA => a uridine in tRNA
RHEA:69498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanal + H2O2 => decan-1-ol + O2
REACT:R-DME-4086392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Drosophila melanogaster)
REACT:R-BTA-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Bos taurus)
RHEA:43107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + an N-acyleicosasphinganine + O2 <=> A + an N-acyleicosasphing-4-enine + 2 H2O
REACT:R-SSC-997309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of STAT1 by SHP2 (Sus scrofa)
RHEA:24521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH
RHEA:70317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine => beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol
RHEA:44299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA <=> 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA
REACT:R-HSA-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Homo sapiens)
REACT:R-RNO-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Rattus norvegicus)
REACT:R-HSA-1980112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)
GO:0052771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F390-G hydrolase activity
GO:0052771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxyguanylylated-coenzyme F420 hydrolase activity
GO:0033558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein lysine deacetylase activity
GO:0033558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein deacetylase activity
GO:0033558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates FOXO1 (Homo sapiens)
REACT:R-DRE-5686578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates ABL1 (Danio rerio)
RHEA:69462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine => [thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine
RHEA:31005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germanicol => (S)-2,3-epoxysqualene
GO:0102152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta12-linoleate epoxygenase activity
REACT:R-SPO-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Schizosaccharomyces pombe)
RHEA:55475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:64013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine => A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine
REACT:R-DRE-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Danio rerio)
REACT:R-MMU-196350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Mus musculus)
RHEA:70252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol => cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine
RHEA:55227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-DRE-1181149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Danio rerio)
GO:0034070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside 1-N-acetyltransferase activity
REACT:R-MMU-8964246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in G alpha (12)-BTK complex is activated (Mus musculus)
REACT:R-XTR-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Xenopus tropicalis)
RHEA:11365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + pyruvate => AMP + 2 H(+) + phosphate + phosphoenolpyruvate
RHEA:34538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + L-alanine <=> 1-deoxy-3-dehydrosphinganine + CO2 + CoA
REACT:R-BTA-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Bos taurus)
REACT:R-RNO-1855200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Rattus norvegicus)
RHEA:53702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O
REACT:R-HSA-112042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid binds MOR (Homo sapiens)
RHEA:55571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine <=> 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine
REACT:R-BTA-9026007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Bos taurus)
REACT:R-CFA-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Canis familiaris)
REACT:R-CEL-9638064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Caenorhabditis elegans)
GO:0102408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity
REACT:R-GGA-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Gallus gallus)
REACT:R-BTA-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Bos taurus)
REACT:R-DRE-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Danio rerio)
REACT:R-DRE-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Danio rerio)
REACT:R-XTR-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Xenopus tropicalis)
RHEA:63656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-GGA-429567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Gallus gallus)
REACT:R-HSA-168869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol (Homo sapiens)
REACT:R-HSA-8982703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC binds active G alpha (z) (Homo sapiens)
REACT:R-DME-2396561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)
RHEA:59697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotetraono-1,5-lactone + H2O => D-cellotetraonate + H(+)
GO:0018448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylmethylsilanediol oxidase activity
RHEA:61366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate => ATP + dehydroepiandrosterone 3-sulfate(in) + H2O
REACT:R-HSA-918227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TRAF3 to MAVS (Homo sapiens)
REACT:R-SPO-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Schizosaccharomyces pombe)
REACT:R-BTA-76397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Bos taurus)
GO:0047884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD pyrophosphatase activity
GO:0047884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD diphosphatase activity
GO:0047884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD nucleotidohydrolase activity
GO:0047884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin adenine dinucleotide pyrophosphatase activity
GO:0047884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavine adenine dinucleotide pyrophosphatase activity
GO:0047884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin adenine dinucleotide pyrophosphatase activity
GO:0047884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavine adenine dinucleotide pyrophosphatase activity
GO:0047884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD pyrophosphohydrolase activity
REACT:R-SSC-909725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IRF9 with p-STAT2:p-STAT1 (Sus scrofa)
REACT:R-DDI-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Dictyostelium discoideum)
REACT:R-BTA-1602399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLB1 (Bos taurus)
RHEA:31076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O
RHEA:21640	skos:prefLabel	"prephenate dehydrogenase (NADP(+))"
RHEA:21640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH
RHEA:21640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prephenate dehydrogenase (NADP(+))"
RHEA:54335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:27580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-piperazine-2-carboxylate + tert-butylamine => (R)-N-tert-butylpiperazine-2-carboxamide + H2O
REACT:R-MMU-8854052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the SCF-FBXL7 complex (Mus musculus)
REACT:R-HSA-8875531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS4 (Homo sapiens)
REACT:R-SSC-879594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO4C1 mediates the transport of digoxin (Sus scrofa)
REACT:R-DDI-8850945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates PTEN (Dictyostelium discoideum)
RHEA:49216	skos:prefLabel	"3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase"
RHEA:49216	skos:altLabel	"2-keto-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate-9-phosphate phosphatase"
RHEA:49216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase"
RHEA:49216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate
REACT:R-SPO-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Schizosaccharomyces pombe)
REACT:R-CFA-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Canis familiaris)
REACT:R-HSA-9717392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region (Homo sapiens)
RHEA:11863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidyl-[protein] <=> ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]
REACT:R-XTR-5138441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A-FZD4 recruits DVL2 (Xenopus tropicalis)
REACT:R-HSA-5694441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1D phosphorylates SEC23 (Homo sapiens)
RHEA:27336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate + 2 H(+) + NADH + O2 <=> 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)
RHEA:13827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-alpha-D-rhamnose + NAD(+)
GO:0015347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Homo sapiens)
GO:0015347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-independent organic anion transmembrane transporter activity
REACT:R-SSC-5654651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS3 (Sus scrofa)
RHEA:51943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2S)-2-methylbutanal oxime <=> (1Z,2S)-2-methylbutanal oxime
RHEA:10704	skos:altLabel	"valine translase"
RHEA:10704	skos:prefLabel	"valine--tRNA ligase"
RHEA:10704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valine--tRNA ligase"
RHEA:10704	skos:altLabel	"valyl-tRNA synthetase"
RHEA:10704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)
RHEA:34734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine
RHEA:67314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myceliothermophin E => (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one
RHEA:24362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+) + sirohydrochlorin => 2 H(+) + siroheme
REACT:R-HSA-9619478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMKK2 phosphorylates AMPK (Homo sapiens)
RHEA:37212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-GMP + H2O => guanosine 2'-monophosphate + H(+)
REACT:R-MMU-3296301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCRL2 binds CCL19 (Mus musculus)
REACT:R-RNO-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Rattus norvegicus)
RHEA:72370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + succinate(in) <=> estrone 3-sulfate(in) + succinate(out)
RHEA:64330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (7Z)-octadecenoate + CoA => (7Z)-octadecenoyl-CoA + cholesterol
REACT:R-DRE-354124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pPTK2 by SRC (Danio rerio)
REACT:R-CEL-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Caenorhabditis elegans)
REACT:R-HSA-9768764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST binds promoter and the first intron of NPAS4 gene (Homo sapiens)
REACT:R-CFA-804969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B1 hydrogenates E1 to EST17b (Canis familiaris)
REACT:R-BTA-6786650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDHD1,2 hydrolyse PA (Bos taurus)
RHEA:50407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] <=> 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]
RHEA:22136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 = chlorophyllide b + 2 H2O + NADP(+)
REACT:R-MMU-2213205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type XII and XIV collagens associate with type I and type II fibrils. (Mus musculus)
REACT:R-MMU-9677929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB inhibitors bind MAOB:FAD (Mus musculus)
RHEA:34714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphing-4-enine <=> 15-methylhexadecasphing-4-enine + a fatty acid
REACT:R-MMU-9700156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK dimer binds IRS1 (Mus musculus)
REACT:R-HSA-416358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) inhibits PI3K alpha (Homo sapiens)
REACT:R-CEL-1602473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP1 (Caenorhabditis elegans)
REACT:R-GGA-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Gallus gallus)
REACT:R-GGA-9014424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the phagocytic vesicle membrane (Gallus gallus)
REACT:R-BTA-1028817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Bos taurus)
REACT:R-DRE-390595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Troponin-C (Danio rerio)
REACT:R-MMU-9007539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates E2F6 (Mus musculus)
REACT:R-DRE-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Danio rerio)
REACT:R-CEL-158766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Caenorhabditis elegans)
RHEA:49811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + butan-1-ol <=> a quinol + butanal
GO:0005540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyaluronic acid binding
GO:0005540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyaluronan binding
REACT:R-BTA-140806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINC1 binds SERPINC1 activators (Bos taurus)
REACT:R-DRE-2507854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Danio rerio)
REACT:R-HSA-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Homo sapiens)
REACT:R-SSC-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Sus scrofa)
REACT:R-DRE-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Danio rerio)
REACT:R-DRE-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Danio rerio)
RHEA:18505	skos:prefLabel	"lysine dehydrogenase"
RHEA:18505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)
RHEA:18505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine dehydrogenase"
RHEA:68868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + benzoate + H(+) + NADPH = AMP + benzaldehyde + diphosphate + NADP(+)
REACT:R-BTA-6814165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates CSA to HTAU (Bos taurus)
REACT:R-CFA-1973968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 4A and 103 bind CCR2 (Canis familiaris)
RHEA:39327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA = (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O
REACT:R-HSA-921155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from the receptor complex (Homo sapiens)
RHEA:61088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + 2-oxoglutarate + O2 = (2R,3R)-dihydroquercetin + CO2 + succinate
REACT:R-BTA-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Bos taurus)
GO:0046997	skos:prefLabel	"With a flavin as acceptor"
GO:0046997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a flavin as acceptor"
GO:0046997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor
REACT:R-RNO-8954262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Rattus norvegicus)
REACT:R-CEL-374899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of noradrenaline  at the synapse (Caenorhabditis elegans)
REACT:R-BTA-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Bos taurus)
REACT:R-DME-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Drosophila melanogaster)
REACT:R-RNO-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
REACT:R-RNO-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Rattus norvegicus)
RHEA:38918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)
REACT:R-SCE-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
RHEA:31791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tuberculosinyl diphosphate = (13S)-edaxadiene + diphosphate
RHEA:66759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + domoate(in) + H2O <=> ADP + domoate(out) + H(+) + phosphate
RHEA:63188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + AH2 + tyramine = A + H2O + norbelladine
RHEA:35736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH
REACT:R-MMU-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Mus musculus)
REACT:R-CEL-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Caenorhabditis elegans)
RHEA:67882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+) => 3'-phosphoadenylyl sulfate + dopamine
REACT:R-HSA-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Homo sapiens)
RHEA:52391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-threonate <=> 4-O-phospho-D-threonate + ADP + H(+)
REACT:R-DME-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Drosophila melanogaster)
RHEA:36453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycyl-L-glutamate(in) + H(+) + phosphate => ATP + glycyl-L-glutamate(out) + H2O
REACT:R-HSA-6798004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates BNIP3L expression (Homo sapiens)
REACT:R-CFA-6810239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)
REACT:R-MMU-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Mus musculus)
REACT:R-SSC-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Sus scrofa)
GO:0015578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose permease activity
GO:0015578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose transmembrane transporter activity
REACT:R-MMU-211873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)
RHEA:11229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-flavan-4-ol + NADP(+) => (2S)-flavanone + H(+) + NADPH
REACT:R-HSA-9661419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds extracellular heme (Homo sapiens)
REACT:R-GGA-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Gallus gallus)
REACT:R-GGA-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Gallus gallus)
REACT:R-DRE-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Danio rerio)
REACT:R-HSA-1168894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A/B dissociates from the Growth Hormone receptor (Homo sapiens)
RHEA:62869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 => H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)
RHEA:13973	skos:altLabel	"H(+)-PPase"
RHEA:13973	skos:altLabel	"vacuolar H(+)-pyrophosphatase"
RHEA:13973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"H(+)-exporting diphosphatase"
RHEA:13973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate
RHEA:13973	skos:prefLabel	"H(+)-exporting diphosphatase"
RHEA:13973	skos:altLabel	"hydrogen-translocating pyrophosphatase"
RHEA:13973	skos:altLabel	"proton-pumping diphosphatase"
RHEA:13973	skos:altLabel	"proton-pumping pyrophosphatase"
REACT:R-DRE-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Danio rerio)
GO:0102326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity
REACT:R-MMU-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Mus musculus)
REACT:R-RNO-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Rattus norvegicus)
REACT:R-CEL-975311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Caenorhabditis elegans)
REACT:R-DDI-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Dictyostelium discoideum)
REACT:R-DME-9617067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Drosophila melanogaster)
REACT:R-SSC-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Sus scrofa)
RHEA:34637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + pentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2
REACT:R-RNO-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Rattus norvegicus)
REACT:R-SSC-212007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1 4-hydroxylate atRA (Sus scrofa)
REACT:R-HSA-167097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIV Promoter Opening: First Transition (Homo sapiens)
REACT:R-XTR-8931653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Xenopus tropicalis)
GO:0102581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside-p-coumaroyltransferase activity
REACT:R-GGA-4224014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by ADAM10, ADAM15 (Gallus gallus)
RHEA:38830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:35066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyrazinamide <=> NH4(+) + pyrazine-2-carboxylate
REACT:R-BTA-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Bos taurus)
REACT:R-BTA-5635855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Bos taurus)
REACT:R-DRE-9653514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17L2 deubiquitinates RCE1 (Danio rerio)
REACT:R-MMU-400097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-beta:G-gamma inhibits Adenylate cyclase (Mus musculus)
RHEA:51085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:47526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => cholate + NAD(+)
REACT:R-HSA-1433488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHP2 by SFKs (Homo sapiens)
REACT:R-BTA-1678694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Bos taurus)
RHEA:61328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + parthenolide + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-372559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
REACT:R-GGA-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Gallus gallus)
RHEA:50954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin => 7-chloro-L-tryptophan + AH2 + O2
GO:0019158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-mannose 6-phosphotransferase activity
GO:0019158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannokinase (phosphorylating)
GO:0019158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannokinase activity
GO:0019158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose (D-mannose) kinase activity
REACT:R-SSC-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Sus scrofa)
RHEA:30218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 2 nitric oxide <=> a menaquinone + H2O + nitrous oxide
REACT:R-XTR-5687120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Xenopus tropicalis)
REACT:R-MMU-5649658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves DHU from damaged DNA (Mus musculus)
REACT:R-DRE-9617996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Danio rerio)
RHEA:39997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ethanolamine => an N-acylethanolamine + H2O
RHEA:60722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hept-2-enoate + 2 H(+) + NADPH => (E)-hept-2-enal + H2O + NADP(+)
REACT:R-DME-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Drosophila melanogaster)
REACT:R-CFA-174786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Canis familiaris)
REACT:R-MMU-937032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
REACT:R-SSC-9734535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Sus scrofa)
REACT:R-RNO-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Rattus norvegicus)
RHEA:55758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxyornithine lipid + CO2 + succinate => 2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2
REACT:R-HSA-2243931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-lysinonorleucine cross-links (Homo sapiens)
RHEA:55612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O = 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)
REACT:R-RNO-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Rattus norvegicus)
REACT:R-HSA-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
REACT:R-BTA-5229111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 transports APP from trans-Golgi network to endosome lumen (Bos taurus)
RHEA:16256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) <=> H(+) + NADH + phenanthrene-3,4-diol
REACT:R-DRE-264458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of COP1 (Danio rerio)
GO:0008890	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-3-ketobutyrate-CoA ligase activity
GO:0008890	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-3-ketobutyrate coenzyme A ligase activity
GO:0008890	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-3-ketobutyrate CoA ligase activity
GO:0008890	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoacetone synthase activity
GO:0008890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine C-acetyltransferase activity
GO:0008890	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:glycine C-acetyltransferase activity
GO:0008890	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine acetyltransferase activity
RHEA:22762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + hnu + oxidized Cypridina luciferin => Cypridina luciferin + O2
REACT:R-SSC-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)
GO:0033737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-aminobutyraldehyde dehydrogenase activity
GO:0033737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	YdcW
GO:0033737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-pyrroline:NAD+ oxidoreductase activity
GO:0033737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline dehydrogenase activity
GO:0033737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ABALDH
RHEA:13212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 3 H2O + trithionate <=> AH2 + 4 H(+) + 3 sulfite
RHEA:57892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + 5 H(+)(in) + NADPH = a quinol + 4 H(+)(out) + NADP(+)
GO:0099095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-gated anion channel activity
REACT:R-DME-912727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds VAV (Drosophila melanogaster)
RHEA:64855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + octan-1-ol <=> CoA + octyl benzoate
RHEA:63217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-carbaguanosine(15) in tRNA + L-lysine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA
RHEA:40236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + fumarate => coenzyme M-coenzyme B heterodisulfide + succinate
RHEA:42693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate => [(1->4)-alpha-D-glucosyl](n+2) + phosphate
REACT:R-BTA-2730903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of TRAF6 (Bos taurus)
REACT:R-DME-209840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two DITs combine to form thyroxine (Drosophila melanogaster)
RHEA:25932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylquinoline + A + H2O = 4-methylquinolin-2(1H)-one + AH2
REACT:R-MMU-6803545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to phagosomal lumen (Mus musculus)
EC:3.6.1.69	skos:prefLabel	"8-oxo-(d)GTP phosphatase"
EC:3.6.1.69	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-oxo-(d)GTP phosphatase"
RHEA:25452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + germacrene A
REACT:R-MMU-1168640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated IkB is degraded (Mus musculus)
RHEA:58313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-substituted-cholesteryl beta-D-glucoside + H2O => 25-substituted-cholesterol + D-glucose
GO:0047865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethylglycine:acceptor oxidoreductase (demethylating)
GO:0047865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethylglycine oxidase activity
GO:0047865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylglycine dehydrogenase activity
GO:0047865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)
REACT:R-DRE-9008258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 binds ESR1:estrogen:TFGA gene (Danio rerio)
REACT:R-HSA-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Homo sapiens)
RHEA:36035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH
REACT:R-DRE-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Danio rerio)
RHEA:68687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) <=> adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)
REACT:R-MMU-6811431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Mus musculus)
REACT:R-XTR-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Xenopus tropicalis)
REACT:R-DME-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Drosophila melanogaster)
RHEA:29747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate(in) = 3-phenylpropanoate(out)
REACT:R-CEL-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Caenorhabditis elegans)
REACT:R-CEL-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
REACT:R-CFA-428231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Canis familiaris)
REACT:R-RNO-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Rattus norvegicus)
RHEA:27353	skos:prefLabel	"demethylrebeccamycin-D-glucose O-methyltransferase"
RHEA:27353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-demethylrebeccamycin + S-adenosyl-L-methionine = H(+) + rebeccamycin + S-adenosyl-L-homocysteine
RHEA:27353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethylrebeccamycin-D-glucose O-methyltransferase"
REACT:R-HSA-198958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Homo sapiens)
REACT:R-DME-8957265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades TP73 polyubiquitinated by ITCH (Drosophila melanogaster)
RHEA:71260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + phosphate(out) => 2 Na(+)(in) + phosphate(in)
REACT:R-XTR-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Xenopus tropicalis)
RHEA:16222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RHEA:23005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP
RHEA:70714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(in) <=> D-alanine(out)
RHEA:22903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH
REACT:R-DDI-4793925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S303,307-HSF1 binds YWHAE (14-3-3) (Dictyostelium discoideum)
REACT:R-CFA-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Canis familiaris)
RHEA:55077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + H(+) => 3-methylsulfanylpropanal + CO2
GO:0140031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylation-dependent protein binding
RHEA:47921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)/18:0) + H2O => ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate
RHEA:38050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-9622738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1) (Homo sapiens)
REACT:R-BTA-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Bos taurus)
REACT:R-CFA-9718379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds chemical antagonists (Canis familiaris)
REACT:R-RNO-3858489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds DAAM1 (Rattus norvegicus)
RHEA:42258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanoyl-[ACP] + CO2 + CoA => H(+) + hexanoyl-CoA + malonyl-[ACP]
RHEA:35556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid
REACT:R-GGA-77584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Gallus gallus)
REACT:R-SCE-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Saccharomyces cerevisiae)
REACT:R-XTR-5690785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds Ub-HCFC1 (Xenopus tropicalis)
RHEA:54828	skos:prefLabel	"dimethylamine monooxygenase"
RHEA:54828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylamine monooxygenase"
RHEA:54828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + H(+) + NADPH + O2 = formaldehyde + H2O + methylamine + NADP(+)
REACT:R-BTA-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Bos taurus)
REACT:R-DRE-5654625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds SHC1 (Danio rerio)
REACT:R-SSC-158941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Sus scrofa)
REACT:R-SSC-140748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Sus scrofa)
REACT:R-CFA-9731661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)
REACT:R-SPO-1482546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)
RHEA:33582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate <=> H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
REACT:R-XTR-9025969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Xenopus tropicalis)
REACT:R-GGA-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Gallus gallus)
GO:0047021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxyprostaglandin dehydrogenase (NADP+) activity
GO:0047021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP-specific 15-hydroxyprostaglandin dehydrogenase
GO:0047021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP-linked 15-hydroxyprostaglandin dehydrogenase
GO:0047021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP-dependent 15-hydroxyprostaglandin dehydrogenase
GO:0047021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II 15-hydroxyprostaglandin dehydrogenase activity
GO:0047021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity
RHEA:13017	skos:altLabel	"UMP diphosphorylase"
RHEA:13017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil
RHEA:13017	skos:prefLabel	"uracil phosphoribosyltransferase"
RHEA:13017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uracil phosphoribosyltransferase"
RHEA:13017	skos:altLabel	"UMP pyrophosphorylase"
REACT:R-SSC-5654597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Sus scrofa)
REACT:R-HSA-8951926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 gene expression is inhibited by RUNX3 (Homo sapiens)
REACT:R-DDI-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Dictyostelium discoideum)
GO:0052879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity
GO:0052879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming) activity
GO:0052879	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	8-hydroperoxide isomerase activity
GO:0052879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate diol synthase activity
RHEA:46928	skos:prefLabel	"monoglucosyldiacylglycerol epimerase"
RHEA:46928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monoglucosyldiacylglycerol epimerase"
RHEA:46928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol
RHEA:46928	skos:altLabel	"glucolipid epimerase"
REACT:R-HSA-9021609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR-associated SRC autophosphorylates (Homo sapiens)
REACT:R-DME-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Drosophila melanogaster)
REACT:R-XTR-5651657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)
RHEA:57905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate
REACT:R-XTR-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Xenopus tropicalis)
REACT:R-SPO-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Schizosaccharomyces pombe)
REACT:R-XTR-182990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty sequesters CBL away from active EGFR (Xenopus tropicalis)
REACT:R-DRE-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Danio rerio)
REACT:R-BTA-377643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
REACT:R-CFA-8849094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RASA1 (Canis familiaris)
RHEA:15536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH
REACT:R-CFA-9706340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y-GRB10 binds PIK3R1 (Canis familiaris)
RHEA:21758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + secologanin => deacetylisoipecoside + H2O
REACT:R-CEL-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Caenorhabditis elegans)
REACT:R-RNO-2179387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Rattus norvegicus)
RHEA:19304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine + S-adenosyl-L-methionine <=> H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine
REACT:R-DME-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Drosophila melanogaster)
REACT:R-XTR-5655193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIAA0101 double monoubiquitination (Xenopus tropicalis)
REACT:R-RNO-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Rattus norvegicus)
REACT:R-HSA-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Homo sapiens)
REACT:R-HSA-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
REACT:R-CEL-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Caenorhabditis elegans)
RHEA:56515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate
EC:3.1.26.-	skos:prefLabel	"Endoribonucleases producing 5'-phosphomonoesters"
EC:3.1.26.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Endoribonucleases producing 5'-phosphomonoesters"
RHEA:28408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphate + XDP => H2O + XTP
REACT:R-DME-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Drosophila melanogaster)
RHEA:25231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arabinose + NADPH => L-arabinitol + NADP(+)
RHEA:61062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + H(+) + UDP => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose
REACT:R-MMU-9748983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6MP, forming 6MeMP (Mus musculus)
REACT:R-SSC-1112703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 is phosphorylated (Sus scrofa)
REACT:R-CFA-1299338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRESK (Canis familiaris)
GO:0034458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 3' to 5' RNA helicase activity
GO:0034458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5' RNA helicase activity
GO:0034458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' to 5' RNA helicase activity
GO:0034458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 3'-5' RNA helicase activity
REACT:R-RNO-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Rattus norvegicus)
REACT:R-HSA-5617452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retinoic acid activates HOXB1 chromatin (Homo sapiens)
REACT:R-RNO-5607759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIKA2 binds K63polyUb-TRAF6 oligomer (Rattus norvegicus)
RHEA:51996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-265427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Mus musculus)
RHEA:15136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH + NH4(+)
RHEA:20352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene <=> 2-hydroxytoluene + H2O + NAD(+)
REACT:R-CFA-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Canis familiaris)
RHEA:13442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteate => H(+) + NH4(+) + pyruvate + sulfite
REACT:R-SCE-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Saccharomyces cerevisiae)
RHEA:38116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol => 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-HSA-173745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3(H2O)-bound Factor B (Homo sapiens)
REACT:R-SSC-400677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rnd1 interacts with Plexin-B1:Sema4D (Sus scrofa)
REACT:R-RNO-191656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Closure of gap junction (Rattus norvegicus)
REACT:R-SSC-3296233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T2Rs bind bitter-tasting compounds (Sus scrofa)
REACT:R-RNO-976801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I complex formation (Rattus norvegicus)
REACT:R-GGA-1614362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Gallus gallus)
REACT:R-RNO-2168887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Albumin to Hemopexin (Rattus norvegicus)
RHEA:44572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) = 2-all-trans-heptaprenylphenol + CO2
RHEA:58603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine
REACT:R-HSA-211178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO1A is excluded from the nucleus (Homo sapiens)
REACT:R-SPO-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
REACT:R-HSA-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Homo sapiens)
GO:0102712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A13,oxoglutarate:oxygen oxidoreductase activity
REACT:R-RNO-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Rattus norvegicus)
REACT:R-HSA-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Homo sapiens)
RHEA:70469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2
REACT:R-SSC-8939335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 polyubiquinates BCL10 (Sus scrofa)
REACT:R-XTR-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)
REACT:R-RNO-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Rattus norvegicus)
GO:0034483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan sulfate sulfotransferase activity
REACT:R-SPO-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Schizosaccharomyces pombe)
REACT:R-SSC-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Sus scrofa)
RHEA:18988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate <=> isochorismate
REACT:R-MMU-202233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Lck by Csk (Mus musculus)
RHEA:68133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytol + tetradecanoyl-CoA => CoA + tetradecanoate phytyl ester
GO:0003953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD nucleosidase activity
GO:0003953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ nucleosidase activity
REACT:R-DRE-1981128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Danio rerio)
RHEA:28420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinyl-CoA + 4-(trimethylamino)butanoate => (R)-carnitine + gamma-butyrobetainyl-CoA
RHEA:52823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + succinyl-CoA <=> CoA + O-succinyl-L-serine
GO:1990518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded 3'-5' DNA helicase activity
REACT:R-DME-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)
RHEA:53787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-muricholate + deoxycholoyl-CoA <=> beta-muricholoyl-CoA + deoxycholate
RHEA:46240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-RNO-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Rattus norvegicus)
RHEA:34218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) <=> 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH
REACT:R-XTR-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Xenopus tropicalis)
REACT:R-DRE-1306963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Danio rerio)
REACT:R-SSC-380869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked dopamine loaded synaptic vesicle (Sus scrofa)
REACT:R-GGA-975594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLB1 hydrolyses RPALM to atROL (Gallus gallus)
RHEA:27771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
RHEA:70390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-3-oxosphinganine
RHEA:31880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => beta-seco-amyrin
RHEA:42567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(38/39) in tRNA <=> pseudouridine(38/39) in tRNA
RHEA:65431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deamido-NAD(+)(in) + NAD(+)(out) <=> deamido-NAD(+)(out) + NAD(+)(in)
REACT:R-MMU-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Mus musculus)
RHEA:43723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juvenile hormone III carboxylate + S-adenosyl-L-methionine <=> juvenile hormone III + S-adenosyl-L-homocysteine
REACT:R-HSA-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Homo sapiens)
GO:0022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity
GO:0022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbitol PTS transporter activity
RHEA:35353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-CoA + H(+) + NADPH => NADP(+) + octadecanoyl-CoA
REACT:R-DDI-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)
REACT:R-DME-9014812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBOs bind keratan sulfate (Drosophila melanogaster)
REACT:R-DDI-1855172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
REACT:R-SSC-429529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin binding to GP1b:IX:V (Sus scrofa)
RHEA:34197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 aureusidin 6-O-beta-glucoside + 2 H2O => 2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2
REACT:R-RNO-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
RHEA:70133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-201422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Danio rerio)
RHEA:13410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanine + 2 NADP(+) => 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH
REACT:R-RNO-3229102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPKAPK3 phosphorylates BMI1 (Rattus norvegicus)
REACT:R-GGA-8951499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides on to class I MHC (Gallus gallus)
REACT:R-GGA-8936214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCY2C trimer binds GUCA2A,B (Gallus gallus)
RHEA:35950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochanoclavine-I aldehyde + NADP(+) <=> chanoclavine-I aldehyde + H(+) + NADPH
REACT:R-DRE-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)
RHEA:37127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dioxidophosphate + H2O2 = CO2 + H(+) + phosphonate + succinate
REACT:R-MMU-5577050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Mus musculus)
REACT:R-SSC-8961021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD binds with itself to form SFTPD 12mer (Sus scrofa)
REACT:R-RNO-449087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD4 binds Interleukin-16 (Rattus norvegicus)
REACT:R-BTA-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Bos taurus)
RHEA:63004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+)
RHEA:25741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-6790036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of STAT3-upregulated nuclear proteins (Homo sapiens)
REACT:R-BTA-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Bos taurus)
REACT:R-GGA-9625482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated EGFR (Gallus gallus)
REACT:R-RNO-983700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds the activated BCR (Rattus norvegicus)
REACT:R-HSA-202394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CARMA1 to Plasma membrane (Homo sapiens)
REACT:R-CFA-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Canis familiaris)
GO:0047809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-2-hydroxy-acid dehydrogenase activity
GO:0047809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy acid dehydrogenase activity
GO:0047809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity
REACT:R-DRE-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Danio rerio)
REACT:R-BTA-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Bos taurus)
RHEA:17615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + scyllo-inosose => NAD(+) + scyllo-inositol
REACT:R-DRE-6814374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kazrin binds periplakin (Danio rerio)
RHEA:62969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + NADP(+) => H(+) + NADPH + pyruvate
REACT:R-SSC-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)
RHEA:28949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-arabinose(out) => H(+)(out) + L-arabinose(in)
REACT:R-DRE-381435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Danio rerio)
RHEA:45466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:53130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epsilon-carotene => delta-carotene
REACT:R-SSC-2161293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin forms aggregate globules (Sus scrofa)
RHEA:31969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-PFA-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Plasmodium falciparum)
GO:0050392	skos:prefLabel	"vicianin beta-glucosidase"
GO:0050392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vicianin beta-glucosidase activity
GO:0050392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vicianin b-glucosidase activity
GO:0050392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vicianin hydrolase activity
GO:0050392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-vicianin beta-D-glucohydrolase activity
GO:0050392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-vicianin + H2O = mandelonitrile + vicianose
GO:0050392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vicianin beta-glucosidase"
RHEA:28498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + mycothiol = S-(hydroxymethyl)mycothiol
RHEA:47344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-381487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP1 binds IGF forming IGF:IGFBP1 (Rattus norvegicus)
REACT:R-CFA-2179274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD3 phosphorylated in the linker region (Canis familiaris)
RHEA:42746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine
REACT:R-RNO-422104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase octanoylates Proghrelin (Rattus norvegicus)
GO:0022842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	narrow pore channel activity
REACT:R-HSA-109700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT2 binds PIP3 (Homo sapiens)
REACT:R-BTA-4551738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO2,3 (Bos taurus)
REACT:R-DME-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Drosophila melanogaster)
REACT:R-HSA-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Homo sapiens)
REACT:R-GGA-167433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta-gamma subunits rebind the alpha-GDP subunit (Gallus gallus)
RHEA:35730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-dodecanoyl-sn-glycerol 3-phosphate + CoA
RHEA:23781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate + propanoyl-CoA => (2S,3S)-2-methylcitrate + CoA + H(+)
RHEA:72883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-phenylpyruvate + 2 ATP = 2 AMP + 2 diphosphate + H(+) + polyporic acid
REACT:R-DME-9679028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 binds JAK3 inhibitors (Drosophila melanogaster)
REACT:R-RNO-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Rattus norvegicus)
REACT:R-PFA-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Plasmodium falciparum)
REACT:R-HSA-8938328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds the NFE2 gene promoter (Homo sapiens)
REACT:R-CFA-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Canis familiaris)
REACT:R-SCE-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)
REACT:R-CFA-5654684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR4 (Canis familiaris)
REACT:R-XTR-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Xenopus tropicalis)
REACT:R-HSA-918230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)
RHEA:18539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + salicylate => H2O + NAD(+) + salicylaldehyde
REACT:R-HSA-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Homo sapiens)
REACT:R-BTA-6807229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)
REACT:R-SCE-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Saccharomyces cerevisiae)
RHEA:19647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-threo-aldono-1,5-lactone + H(+) + NADH => a D-threo-aldose + NAD(+)
REACT:R-MMU-5669158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF2 binds PAK1 (Mus musculus)
RHEA:56126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + diphosphate + nonaflavuxanthin => A + all-trans-lycopene + dimethylallyl diphosphate + H2O
REACT:R-HSA-389350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 by pVav1 (Homo sapiens)
REACT:R-RNO-5665989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIAPH1 binds RHOA:GTP (Rattus norvegicus)
RHEA:12908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GDP + H(+) <=> GDP-alpha-D-mannose + phosphate
REACT:R-DRE-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Danio rerio)
RHEA:27815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(in) + Na(+)(in) => acetate(out) + Na(+)(out)
REACT:R-CFA-9026967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 inhibitors binds VKORC1 dimer (Canis familiaris)
RHEA:20076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allothreonine <=> acetaldehyde + glycine
RHEA:38014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a + H2O <=> chlorophyllide a + H(+) + phytol
REACT:R-HSA-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Homo sapiens)
REACT:R-HSA-1169210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B dephosphorylates JAK2 (Homo sapiens)
REACT:R-DDI-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)
REACT:R-HSA-2046222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Homo sapiens)
REACT:R-BTA-5610754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Bos taurus)
RHEA:13478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan + NADP(+) => H(+) + indole-3-pyruvate + NADPH + NH4(+)
REACT:R-BTA-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Bos taurus)
RHEA:53018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + glutathione disulfide + H(+) + hydroquinone => chlorohydroquinone + 2 glutathione
REACT:R-MMU-8858369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVRL1 binds BMP9,BMP10 (Mus musculus)
RHEA:61329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + parthenolide + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-valine + tRNA(Val) <=> AMP + diphosphate + L-valyl-tRNA(Val)
EC:3.5.1.109	skos:altLabel	"SM glucosylceramide GCer deacylase"
EC:3.5.1.109	skos:prefLabel	"sphingomyelin deacylase"
EC:3.5.1.109	skos:altLabel	"sphingomyelin glucosylceramide deacylase"
EC:3.5.1.109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingomyelin deacylase"
EC:3.5.1.109	skos:altLabel	"glucosylceramide sphingomyelin deacylase"
EC:3.5.1.109	skos:altLabel	"SMGCer deacylase"
EC:3.5.1.109	skos:altLabel	"SM deacylase"
RHEA:11527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH
REACT:R-CEL-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Caenorhabditis elegans)
REACT:R-SSC-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Sus scrofa)
RHEA:72015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine = 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A
RHEA:21227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-choline + sphing-4-enine <=> CMP + H(+) + sphing-4-enine-phosphocholine
REACT:R-HSA-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Homo sapiens)
REACT:R-CEL-1169403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 ligase with ISG15:E2 complex (Caenorhabditis elegans)
RHEA:34697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(6)-protoilludene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:18406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanine + NAD(+) => H(+) + NADH + NH4(+) + pyruvate
REACT:R-RNO-210277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)
RHEA:35322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + octadecanoyl-CoA <=> 3-oxoeicosanoyl-CoA + CO2 + CoA
RHEA:64477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate
REACT:R-XTR-6785178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Xenopus tropicalis)
REACT:R-MMU-2681667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Mus musculus)
REACT:R-BTA-9009536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX5 binds ESR1:estrogen:TFF1 gene promoter (Bos taurus)
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate transcarbamylase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic transcarbamylase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic carbamyltransferase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate:L-aspartate carbamoyltransferase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate carbamoyltransferase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate transcarbamoylase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic acid transcarbamoylase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate transcarbamylase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate transcarbamoylase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATCase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate carbamyltransferase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoylaspartotranskinase activity
GO:0004070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamylaspartotranskinase activity
REACT:R-DME-3000074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN2 binds RCbl in the circulation (Drosophila melanogaster)
RHEA:21690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an oxidized polyvinyl alcohol + n H2O2 => a polyvinyl alcohol + n O2
REACT:R-RNO-429449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk activation leads to SLP-76 activation (Rattus norvegicus)
REACT:R-SSC-381135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Sus scrofa)
RHEA:22881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arogenate => L-glutamate + prephenate
RHEA:28452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-psicosyl)-L-lysine(out) => N(6)-(D-psicosyl)-L-lysine(in)
REACT:R-HSA-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Homo sapiens)
REACT:R-HSA-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)
RHEA:26004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate + H(+) + NADH => D-arabinitol 1-phosphate + NAD(+)
REACT:R-CFA-70920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Canis familiaris)
REACT:R-GGA-110250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenoadenine by MPG glycosylase (Gallus gallus)
REACT:R-CFA-5607724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
REACT:R-SSC-390597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Sus scrofa)
REACT:R-HSA-5678315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Homo sapiens)
GO:0061758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate dehydrogenase activity, forward reaction
GO:0061758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate reductase activity, reverse reaction
GO:0061758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2
REACT:R-CFA-9012689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Canis familiaris)
RHEA:36042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH
REACT:R-BTA-1604731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP3 (Bos taurus)
RHEA:15396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,6S)-2,6-diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate
RHEA:68447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-cis-lycopene + O2 <=> (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal
RHEA:14032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + selenite <=> AH2 + selenate
RHEA:27811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + 2 isopentenyl diphosphate => (2Z,6Z)-farnesyl diphosphate + 2 diphosphate
REACT:R-DRE-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Danio rerio)
REACT:R-DDI-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:60025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-chrysanthemyl diphosphate + H2O => (R,R)-chrysanthemol + diphosphate
RHEA:27618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate = di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate
RHEA:67596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptadecasphing-4-enine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine
RHEA:62685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norrubrofusarin + S-adenosyl-L-methionine => H(+) + rubrofusarin + S-adenosyl-L-homocysteine
REACT:R-RNO-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Rattus norvegicus)
REACT:R-SSC-8858498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SL (surrogate light chain) binds IgH to form pre-BCR (Sus scrofa)
REACT:R-MMU-9027532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DHA to 13-HDHA (Mus musculus)
RHEA:66740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate
REACT:R-GGA-199839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate RSK (Gallus gallus)
RHEA:41124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)
RHEA:53555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:13783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H2O2 + NH4(+) => an L-alpha-amino acid + H2O + O2
RHEA:35648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP => 3',3'-cGAMP + 2 diphosphate
REACT:R-MMU-389491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two NPFF receptors can bind neuropeptide FF (Mus musculus)
RHEA:55009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 => (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)
RHEA:71374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone 17-sulfate(out) + 2 Na(+)(out) <=> epitestosterone 17-sulfate(in) + 2 Na(+)(in)
RHEA:58636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate
RHEA:65582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphate + TDP => H2O + TTP
REACT:R-XTR-5685366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y-SHC (Xenopus tropicalis)
RHEA:71398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)
RHEA:18630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NAD(+) => ADP + H(+) + NADP(+)
REACT:R-RNO-2028598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS1 (Rattus norvegicus)
REACT:R-CFA-8987033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Canis familiaris)
RHEA:29964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + inosine(in) => H(+)(out) + inosine(out)
RHEA:67195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) <=> ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate
RHEA:49962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine + CO2 + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2
GO:0000514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)
GO:0000514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine: proton, glutamate antiporter activity
GO:1990782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine kinase binding
GO:1990782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine kinase binding
REACT:R-RNO-6785213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer binds heparin (Rattus norvegicus)
REACT:R-CFA-74059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Canis familiaris)
RHEA:44476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine
REACT:R-RNO-8863858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC22B, CALR, STX4, TAP and TAPBP bind (Rattus norvegicus)
REACT:R-SPO-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Schizosaccharomyces pombe)
REACT:R-RNO-688137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 is K63 polyubiquitinated (Rattus norvegicus)
RHEA:64970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP + H(+) + phosphate => dUTP + H2O
REACT:R-MMU-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Mus musculus)
REACT:R-BTA-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Bos taurus)
REACT:R-SSC-140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Sus scrofa)
REACT:R-SSC-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Sus scrofa)
RHEA:42049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH
RHEA:43738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine
RHEA:16521	skos:prefLabel	"ferredoxin--NAD(P)(+) reductase (naphthalene dioxygenase ferredoxin-specific)"
RHEA:16521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:16521	skos:altLabel	"NADH-ferredoxin(NAP) reductase"
RHEA:16521	skos:prefLabel	"ferredoxin--NAD(+) reductase"
RHEA:16521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin--NAD(P)(+) reductase (naphthalene dioxygenase ferredoxin-specific)"
RHEA:16521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin--NAD(+) reductase"
REACT:R-DRE-429567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Danio rerio)
REACT:R-HSA-8875320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 GEFs exchange GTP for GDP on RAB5 (Homo sapiens)
REACT:R-DRE-1022129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Danio rerio)
REACT:R-DME-9653514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)
REACT:R-RNO-8939203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Rattus norvegicus)
RHEA:65682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine
REACT:R-CFA-1169404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ISG15 from E1 to E2 (UBCH8) (Canis familiaris)
RHEA:36108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A4 + S-adenosyl-L-methionine => O-methyl gibberellin A4 + S-adenosyl-L-homocysteine
RHEA:36609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-hydroxyarginine + CO2 + succinate => 2-oxoglutarate + L-arginine + O2
RHEA:34905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + 3 H2O + selenodiglutathione => 4 glutathione + 2 H(+) + selenite
REACT:R-XTR-192061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)
REACT:R-MMU-9714480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the mitochondrial membrane (Mus musculus)
RHEA:17611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine => L-seryl-[sulfatase] + S-adenosyl-L-methionine
RHEA:56580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-thioguanine + S-adenosyl-L-methionine = 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine
GO:0019212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatase inhibitor activity
REACT:R-SSC-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Sus scrofa)
REACT:R-MMU-5654664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS binds GRB2:SOS1 (Mus musculus)
GO:0033810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ss5MaT1
GO:0033810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity
GO:0033810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity
REACT:R-MMU-983161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Mus musculus)
REACT:R-SCE-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Saccharomyces cerevisiae)
RHEA:51711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-altritol + NAD(+) <=> H(+) + keto-D-tagatose + NADH
RHEA:42893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + H(+) + H2O => 5'-deoxyinosine + NH4(+)
GO:0015274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organellar voltage-gated chloride channel activity
GO:0015274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organellar voltage-dependent chloride channel activity
GO:0015274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organellar voltage gated chloride channel activity
REACT:R-SSC-9027532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DHA to 13-HDHA (Sus scrofa)
REACT:R-HSA-9027280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K (Homo sapiens)
REACT:R-BTA-8870332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Bos taurus)
REACT:R-CFA-429798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Canis familiaris)
REACT:R-MMU-8961021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD binds with itself to form SFTPD 12mer (Mus musculus)
REACT:R-HSA-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)
REACT:R-MMU-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)
REACT:R-CFA-5218642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Canis familiaris)
REACT:R-DRE-8950766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA dimerizes (Danio rerio)
REACT:R-BTA-3827958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by MMP9, KLK7 (Bos taurus)
REACT:R-DRE-3371353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble TNF-α binds TNFR1 (Danio rerio)
REACT:R-HSA-9680248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of extracellular domain KIT mutants (Homo sapiens)
RHEA:66436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pentan-3-one = H(+) + NADPH + pent-1-en-3-one
REACT:R-DRE-199050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Danio rerio)
REACT:R-HSA-5660514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTF1 dimer:12Zn2+ binds CSRP1 gene (Homo sapiens)
REACT:R-DME-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Drosophila melanogaster)
GO:0031883	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	taste receptor ligand
GO:0031883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taste receptor binding
REACT:R-DRE-351913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of TJP1 (Danio rerio)
REACT:R-HSA-209536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkB is ubiquitinated and degraded (Homo sapiens)
RHEA:32341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-thujan-3-one + H(+) + NADPH => (+)-thujan-3-ol + NADP(+)
RHEA:10312	skos:altLabel	"1,4-dicarboxybenzoate 1,2-dioxygenase"
RHEA:10312	skos:prefLabel	"terephthalate 1,2-dioxygenase"
RHEA:10312	skos:altLabel	"benzene-1,4-dicarboxylate 1,2-dioxygenase"
RHEA:10312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)
RHEA:10312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"terephthalate 1,2-dioxygenase"
RHEA:27391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + salicylaldehyde => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O
GO:0061786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan stem peptide endopeptidase activity
REACT:R-DRE-9014812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBOs bind keratan sulfate (Danio rerio)
GO:0008706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity
GO:0008706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-beta-glucosidase activity
GO:0008706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-beta-glucosidase activity
GO:0008706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphocellobiase activity
GO:0008706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-beta-glucosidase A
GO:0042288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	major histocompatibility complex class I binding
GO:0042288	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T cell receptor activity
GO:0042288	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	major histocompatibility complex class I ligand
GO:0042288	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-beta T cell receptor activity
GO:0042288	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-delta T cell receptor activity
GO:0042288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class I protein binding
RHEA:65563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-kynurenine <=> H2O + kynurenate + L-glutamate
RHEA:64210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + L-glutamine => an N-(fatty acyl)-L-glutamine + H2O
RHEA:41386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-XTR-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Xenopus tropicalis)
REACT:R-CFA-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Canis familiaris)
RHEA:55400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) = archaeosine(15) in tRNA
RHEA:71202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(in) <=> L-ornithine(out)
REACT:R-CFA-9706304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRAP2 (Canis familiaris)
REACT:R-DME-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Drosophila melanogaster)
REACT:R-CFA-173754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Properdin stabilizes C3b:Bb bound to cell surfaces (Canis familiaris)
REACT:R-CFA-265423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Fibrillin (Canis familiaris)
RHEA:58802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-pApG-3' + H(+) => 3',3'-cGAMP + H2O
REACT:R-CFA-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Canis familiaris)
REACT:R-MMU-8854051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL18 ubiquitinates FBXL7 (Mus musculus)
REACT:R-HSA-2426161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the GGPS1 promoter (Homo sapiens)
REACT:R-SPO-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)
RHEA:14206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine + S-adenosyl-L-methionine => anserine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-1855189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 transports from the ER lumen to the nucleus (Homo sapiens)
REACT:R-HSA-560493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Perilipin (PLIN) (Homo sapiens)
RHEA:67458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-MMU-202237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)
RHEA:69719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + ATP + H(+) = (indol-3-yl)acetyl-AMP + diphosphate
REACT:R-XTR-2404200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2 binds IGF1R (Xenopus tropicalis)
REACT:R-DRE-389995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Danio rerio)
REACT:R-HSA-163689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of pChREBP (Ser 196) by PP2A (Homo sapiens)
REACT:R-RNO-373086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR10 binds CCL27 and 28 ligands (Rattus norvegicus)
REACT:R-SCE-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Saccharomyces cerevisiae)
RHEA:54539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acid + ATP + CoA <=> a very long-chain fatty acyl-CoA + AMP + diphosphate
GO:0103084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiobutylmalate dehydrogenase activity
REACT:R-MMU-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Mus musculus)
GO:0042898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fosmidomycin transmembrane transporter activity
GO:0042898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fosmidomycin transporter activity
REACT:R-XTR-5635859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU dissociates (Xenopus tropicalis)
REACT:R-HSA-2400001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates CHUK (IKKalpha) (Homo sapiens)
RHEA:55201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine => 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine
REACT:R-CFA-8862184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP48 cleaves polyubiquitin (Canis familiaris)
REACT:R-CFA-2730872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Calcineurin (Canis familiaris)
REACT:R-MMU-6807027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 and PTPN2 dephosphorylate MET (Mus musculus)
RHEA:42943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(34) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
REACT:R-SCE-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Saccharomyces cerevisiae)
REACT:R-SSC-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Sus scrofa)
RHEA:41784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) = CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)
RHEA:38722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + ATP + H2O <=> (R)-carnitine(in) + ADP + H(+) + phosphate
REACT:R-XTR-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Xenopus tropicalis)
REACT:R-MMU-6804724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates phosphorylated MDM4 (Mus musculus)
REACT:R-MMU-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Mus musculus)
REACT:R-BTA-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Bos taurus)
REACT:R-HSA-6805103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates TP53 (Homo sapiens)
RHEA:45407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate <=> 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
GO:0001618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viral receptor activity
GO:0001618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	virus receptor activity
REACT:R-HSA-6802934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
REACT:R-CFA-5665751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP:FMNL2 binds Profilin:G-actin (Canis familiaris)
RHEA:66962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose
REACT:R-XTR-2029467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by CRKII:DOCK180:ELMO (Xenopus tropicalis)
RHEA:56418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate
GO:0047258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine beta-galactosyltransferase activity
GO:0047258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingosine beta-galactosyltransferase"
GO:0047258	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	psychosine-UDP galactosyltransferase activity
GO:0047258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP
GO:0047258	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity
GO:0047258	skos:prefLabel	"sphingosine beta-galactosyltransferase"
GO:0047258	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosyl-sphingosine transferase activity
GO:0047258	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	psychosine-uridine diphosphate galactosyltransferase activity
GO:0047258	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:sphingosine 1-beta-galactotransferase activity
GO:0047258	skos:altLabel	"psychosine--UDP galactosyltransferase"
GO:0047258	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:sphingosine O-galactosyl transferase activity
GO:0047258	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:sphingosine 1-beta-galactotransferase activity
RHEA:40334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-CFA-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
RHEA:14497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxine 5-dehydrogenase"
RHEA:14497	skos:prefLabel	"pyridoxine 5-dehydrogenase"
RHEA:14497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + pyridoxine = AH2 + isopyridoxal
RHEA:14497	skos:altLabel	"pyridoxol 5-dehydrogenase"
GO:0102285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11-oxopentalenate oxygenase activity
REACT:R-MMU-8858252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDLBP binds HDL (Mus musculus)
RHEA:27978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + H2O = alpha-D-mannose 1-phosphate + GMP + 2 H(+)
RHEA:19551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 orsellinate => H2O + o-orsellinate depside
RHEA:49787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + taurine <=> CoA + H(+) + taurochenodeoxycholate
REACT:R-MMU-73815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)
RHEA:47792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Canis familiaris)
REACT:R-DRE-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Danio rerio)
REACT:R-SPO-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Schizosaccharomyces pombe)
RHEA:63726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	candesartan O-beta-D-glucuronoside + UDP => candesartan + UDP-alpha-D-glucuronate
REACT:R-BTA-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Bos taurus)
REACT:R-DRE-192065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7B1 7-hydroxylates 25OH-CHOL (Danio rerio)
RHEA:14646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-adenosyl-L-methionine => H(+) + L-homoserine + S-methyl-5'-thioadenosine
REACT:R-RNO-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Rattus norvegicus)
RHEA:59936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)
REACT:R-MMU-198870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-GGA-170846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 recruits TGFBR1 (Gallus gallus)
REACT:R-HSA-5691006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
GO:0101014	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isocitrate dehydrogenase kinase/phosphatase activity
GO:0101014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[isocitrate dehydrogenase (NADP+)] phosphatase activity
RHEA:39217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + NADP(+) => (2E)-hexacosenoyl-CoA + H(+) + NADPH
RHEA:16556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]
RHEA:66812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH = 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B
REACT:R-SSC-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Sus scrofa)
RHEA:58379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decan-1-ol + NADP(+) <=> decanal + H(+) + NADPH
RHEA:31857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	achilleol B => (S)-2,3-epoxysqualene
REACT:R-MMU-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Mus musculus)
REACT:R-DDI-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Dictyostelium discoideum)
REACT:R-HSA-9628756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 G83D does not cleave FapyA (Homo sapiens)
REACT:R-MMU-4724284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Mus musculus)
REACT:R-MMU-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Mus musculus)
REACT:R-DRE-1433514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
RHEA:59371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)
GO:0019186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA N-acyltransferase activity
RHEA:12415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + H2O <=> (R)-glycerate + phosphate
REACT:R-BTA-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Bos taurus)
REACT:R-CFA-6814885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBCAP complex binds 7-methylguanosine cap of snRNA (Canis familiaris)
REACT:R-DRE-3322429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP monoubiquinates TLE (Danio rerio)
REACT:R-BTA-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Bos taurus)
REACT:R-RNO-3221982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANP binds TP53 (Rattus norvegicus)
RHEA:19404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol + NAD(+) <=> formaldehyde + H(+) + NADH
REACT:R-CFA-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Canis familiaris)
RHEA:56719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] <=> H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate
RHEA:40928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)
GO:0034579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1-methylpentyl)succinate synthase activity
REACT:R-DME-2045911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
RHEA:20845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + pyruvate => ADP + H(+) + oxaloacetate + phosphate
REACT:R-SSC-9691215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFR2 dimer (Sus scrofa)
REACT:R-HSA-6785732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
RHEA:35545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + phosphate => 3-phosphooxypyruvate + H2O
REACT:R-HSA-9021412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PBX1 gene expression is stimulated by NOTCH3 (Homo sapiens)
REACT:R-RNO-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Rattus norvegicus)
RHEA:36115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A3 + S-adenosyl-L-methionine = O-methyl gibberellin A3 + S-adenosyl-L-homocysteine
RHEA:25038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-tRNA(Sec) => ADP + O-phospho-L-seryl-tRNA(Sec)
REACT:R-BTA-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Bos taurus)
RHEA:15793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin IXalpha + NADP(+) = biliverdin IXalpha + H(+) + NADPH
GO:0018673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA monooxygenase activity
GO:0018673	skos:altLabel	"2-aminobenzoyl-CoA monooxygenase/reductase"
GO:0018673	skos:prefLabel	"anthraniloyl-CoA monooxygenase"
GO:0018673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminobenzoyl-CoA monooxygenase/reductase activity
GO:0018673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthraniloyl-CoA monooxygenase"
GO:0018673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)
GO:0018673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthraniloyl coenzyme A reductase activity
REACT:R-SSC-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Sus scrofa)
RHEA:17652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + malonate <=> acetate + malonyl-[ACP]
REACT:R-DME-165179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TSC1:TSC2 complex (Drosophila melanogaster)
REACT:R-XTR-8862137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B2 oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)
REACT:R-HSA-3318590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MMACHC does not decyanate CNCbl (Homo sapiens)
RHEA:12703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O
RHEA:42634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine
REACT:R-BTA-159443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Bos taurus)
RHEA:35922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose <=> H(+) + kanamycin D + UDP
REACT:R-HSA-1483089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is converted to PS by PTDSS2 (Homo sapiens)
REACT:R-RNO-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Rattus norvegicus)
RHEA:38458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
REACT:R-RNO-9627089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP9 is phosphorylated at T125 (Rattus norvegicus)
REACT:R-BTA-190520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Golgi  transport vesicles with microtubules (Bos taurus)
REACT:R-MMU-8956184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Mus musculus)
RHEA:36724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + A + H2O => 2-phenylacetaldehyde + AH2 + NH4(+)
RHEA:12863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + xanthosine => guanosine + H(+) + H2O
REACT:R-XTR-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Xenopus tropicalis)
REACT:R-BTA-9677917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA inhibitors bind MAOA:FAD (Bos taurus)
RHEA:57968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-epi-inunolide synthase"
RHEA:57968	skos:altLabel	"CYP71BL1"
RHEA:57968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57968	skos:prefLabel	"8-epi-inunolide synthase"
RHEA:51784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlorisovalerophenone + dimethylallyl diphosphate = deoxyhumulone + diphosphate
REACT:R-CFA-6809810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Canis familiaris)
GO:0015319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:inorganic phosphate symporter activity
GO:0033870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiol sulfotransferase activity
GO:0033870	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PAPS sulfotransferase activity
GO:0033870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity
GO:0033870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity
REACT:R-MMU-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Mus musculus)
REACT:R-SCE-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Saccharomyces cerevisiae)
RHEA:18965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylbilane = H2O + uroporphyrinogen III
RHEA:18965	skos:altLabel	"hydroxymethylbilane hydro-lyase (cyclizing)"
RHEA:18965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uroporphyrinogen-III synthase"
RHEA:18965	skos:prefLabel	"uroporphyrinogen-III synthase"
RHEA:18965	skos:altLabel	"uroporphyrinogen-III cosynthase"
RHEA:18965	skos:altLabel	"uroporphyrinogen-III cosynthetase"
REACT:R-DDI-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Dictyostelium discoideum)
RHEA:34194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)
REACT:R-MMU-2130504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of lip22 to lip10 (Mus musculus)
REACT:R-CFA-8939323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 binds BCL10 and Ubiquitin:E2 (Canis familiaris)
RHEA:23699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + O2 <=> D-glucuronate + H(+) + H2O
RHEA:60795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2-oxoglutarate + gibberellin A53 + 3 O2 <=> 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate
REACT:R-RNO-9697747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at TNFR signaling complex (Rattus norvegicus)
RHEA:60189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate
REACT:R-HSA-200908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nef Binds and activates the Src-family tyrosine kinase Fyn (Homo sapiens)
REACT:R-DRE-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Danio rerio)
RHEA:58819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
REACT:R-MMU-5690669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds itself to form homo-oligomers (Mus musculus)
REACT:R-HSA-5601887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer cleaves primary piRNA transcript to pre-piRNA (Homo sapiens)
RHEA:44412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-10 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-10
REACT:R-HSA-5607744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 binds BCL10 (Homo sapiens)
REACT:R-DRE-198813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO dimers reduce DeHA to AscH- (Danio rerio)
REACT:R-HSA-9013652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 coactivator complex binds HES1 gene promoter (Homo sapiens)
REACT:R-BTA-1855225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Bos taurus)
REACT:R-GGA-420911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPAT dimers (Gallus gallus)
REACT:R-RNO-201603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of PKC theta (Rattus norvegicus)
REACT:R-GGA-391935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP1 receptor can bind PGD2 (Gallus gallus)
REACT:R-CFA-8949649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Canis familiaris)
RHEA:49480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-1-piperideine-6-carboxylate + NADP(+) = H(+) + L-2-aminoadipate + NADPH
REACT:R-SSC-5602080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Sus scrofa)
RHEA:68765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine
RHEA:46509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + nitrobenzene + O2 => catechol + NAD(+) + nitrite
RHEA:71453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bradykinin(1-7) + L-Phe-L-Arg => bradykinin + H2O
RHEA:26198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + melamine => ammeline + NH4(+)
REACT:R-BTA-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Bos taurus)
REACT:R-HSA-8864718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter (Homo sapiens)
REACT:R-BTA-9624800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LBR (Bos taurus)
REACT:R-DRE-3000449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Danio rerio)
REACT:R-HSA-9706293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CBL (Homo sapiens)
RHEA:30083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cuproxidase"
RHEA:30083	skos:altLabel	"cuprous oxidase"
RHEA:30083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Cu(+) + 4 H(+) + O2 = 4 Cu(2+) + 2 H2O
RHEA:30083	skos:altLabel	"Cu(I) oxidase"
RHEA:30083	skos:altLabel	"copper efflux oxidase"
RHEA:30083	skos:prefLabel	"cuproxidase"
GO:0015665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol transmembrane transporter activity
EC:1.2.1.59	skos:altLabel	"triosephosphate dehydrogenase (NAD(P))"
EC:1.2.1.59	skos:altLabel	"NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase"
EC:1.2.1.59	skos:prefLabel	"glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)"
EC:1.2.1.59	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)"
EC:1.2.1.59	skos:altLabel	"triosephosphate dehydrogenase (NAD(P)(+))"
REACT:R-CFA-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Canis familiaris)
REACT:R-RNO-2424484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BTK by p-SYK (Rattus norvegicus)
REACT:R-DME-934604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
RHEA:40457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA
REACT:R-RNO-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Rattus norvegicus)
REACT:R-GGA-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Gallus gallus)
REACT:R-BTA-1433506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APS (Bos taurus)
GO:0005185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurohypophysial hormone activity
GO:0005185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurohypophyseal hormone activity
REACT:R-MMU-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Mus musculus)
RHEA:39965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + hexadecanoate => 2-hexadecanoylglycerol + H2O
GO:0004940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta1 adrenoceptor
GO:0004940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta1-adrenergic receptor activity
REACT:R-DRE-2028644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Danio rerio)
REACT:R-CFA-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)
REACT:R-MMU-9667569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,2 bind AVPR antagonists (Mus musculus)
REACT:R-HSA-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Homo sapiens)
RHEA:45944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-BTA-976810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to extracellular Factor H:C3b (Bos taurus)
REACT:R-SCE-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Saccharomyces cerevisiae)
REACT:R-HSA-5662610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1B binds cadmium (Homo sapiens)
REACT:R-CEL-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Caenorhabditis elegans)
REACT:R-DRE-5244669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Danio rerio)
REACT:R-SCE-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Saccharomyces cerevisiae)
REACT:R-CFA-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Canis familiaris)
REACT:R-MMU-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Mus musculus)
RHEA:51226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => 2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate
RHEA:44209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyltridecanoate + ATP + CoA => 12-methyltridecanoyl-CoA + AMP + diphosphate
REACT:R-RNO-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Rattus norvegicus)
RHEA:71328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-threonine(out) + 2 Na(+)(out) => chloride(in) + L-threonine(in) + 2 Na(+)(in)
REACT:R-CEL-5654664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)
RHEA:53684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
REACT:R-RNO-158832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT2 (Rattus norvegicus)
RHEA:41072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-HSA-187035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-beta-NGF and mature beta-NGF are secreted (Homo sapiens)
REACT:R-DRE-8955010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRTOMT transfers Met to DA, forming 3MT (Danio rerio)
REACT:R-HSA-4717461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-2 SUMOylate PPARG with SUMO1 (Homo sapiens)
REACT:R-DME-2187388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Drosophila melanogaster)
REACT:R-SSC-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Sus scrofa)
RHEA:22831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-ATP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)
REACT:R-SSC-202241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SLP-76 to Gads (Sus scrofa)
REACT:R-DDI-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)
REACT:R-MMU-9603983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeX to form LeY (Mus musculus)
REACT:R-HSA-909765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial uptake of beta-alanine (Homo sapiens)
RHEA:64346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+) => 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2
EC:3.4.24.89	skos:prefLabel	"Pro-Pro endopeptidase"
EC:3.4.24.89	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Pro-Pro endopeptidase"
GO:0097161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DH domain binding
REACT:R-SSC-8871376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds PI3P (Sus scrofa)
REACT:R-GGA-77585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Gallus gallus)
REACT:R-SSC-204779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang1 (Sus scrofa)
REACT:R-CFA-6784628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)
REACT:R-HSA-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Homo sapiens)
REACT:R-XTR-8869694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds CD14 (Xenopus tropicalis)
REACT:R-CEL-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Caenorhabditis elegans)
GO:0035539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity
GO:0035539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTPase activity
GO:0035539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity
GO:0035539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
GO:0035539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTP pyrophosphohydrolase activity
GO:0035539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity
GO:0035539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
REACT:R-MMU-375342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 36 mediated neuronal gap junction communication (Mus musculus)
RHEA:35766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Mus musculus)
REACT:R-XTR-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Xenopus tropicalis)
RHEA:71068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-phenylalanine(out) => L-arginine(out) + L-phenylalanine(in)
REACT:R-SCE-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Saccharomyces cerevisiae)
REACT:R-XTR-8851979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL9 binds immune cell surfaces (Xenopus tropicalis)
RHEA:52295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:36043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-8'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial
RHEA:36043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8'-apo-carotenoid 13,14-cleaving dioxygenase"
RHEA:36043	skos:prefLabel	"8'-apo-carotenoid 13,14-cleaving dioxygenase"
REACT:R-CFA-114352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of tBID by BCL-2 (Canis familiaris)
REACT:R-HSA-3209159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERF translocates to the cytosol (Homo sapiens)
RHEA:57601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-73632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Danio rerio)
RHEA:63565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apelin-13 + H2O => apelin-12 + L-phenylalanine
RHEA:43397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)
REACT:R-BTA-199518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3d-complexed antigen binds to complement receptor (Bos taurus)
RHEA:23986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + H(+) + NADPH => cholesterol + NADP(+)
REACT:R-HSA-163666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ChREBP:MLX heterodimer (Homo sapiens)
REACT:R-MMU-5692315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OX40L binds OX40 (Mus musculus)
RHEA:54226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin E2)-sn-glycero-3-phosphocholine => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine
GO:0086088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization
REACT:R-XTR-5684267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Xenopus tropicalis)
REACT:R-HSA-9027624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DHA to 7-HDHA (Homo sapiens)
REACT:R-DRE-8870346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Danio rerio)
RHEA:28091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
RHEA:24144	skos:prefLabel	"isohexenylglutaconyl-CoA hydratase"
RHEA:24144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isohexenylglutaconyl-CoA hydratase"
RHEA:24144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
REACT:R-HSA-2396029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-3 binds integrins (Homo sapiens)
RHEA:13420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,12-dihydroxanthommatin + NAD(+) <=> H(+) + NADH + xanthommatin
REACT:R-MMU-8954110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1:EPC1 binds the PRC2 complex (Mus musculus)
REACT:R-HSA-109699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
REACT:R-MMU-977348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHGDH tetramer dehydrogenates 3PG (Mus musculus)
GO:0016490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of peritrophic membrane
GO:0016490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	structural constituent of peritrophic matrix
REACT:R-RNO-109530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Rattus norvegicus)
REACT:R-DME-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Drosophila melanogaster)
REACT:R-CEL-8938930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF2 (Caenorhabditis elegans)
REACT:R-SSC-2076419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Sus scrofa)
REACT:R-BTA-9033533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)
RHEA:66338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) => L-glutamate(out)
REACT:R-BTA-9013111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GAPs stimulate RHOC GTPase activity (Bos taurus)
REACT:R-MMU-9706293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CBL (Mus musculus)
RHEA:54624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + octadecanoyl-CoA = 2-hydroxyoctadecanoyl-CoA + CO2 + succinate
REACT:R-BTA-9026005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Bos taurus)
REACT:R-HSA-9633005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
RHEA:34007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrodesmosterol + S-adenosyl-L-methionine = 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-392051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Grb2 to pFAK:NCAM1 (Rattus norvegicus)
RHEA:40325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP
REACT:R-DDI-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Dictyostelium discoideum)
REACT:R-CFA-5607757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TRAF6 ubiquitinates TAK1 (Canis familiaris)
REACT:R-MMU-198609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates TSC2, inhibiting it (Mus musculus)
REACT:R-CFA-389481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 1 receptor can bind orexin-A neuropeptide (Canis familiaris)
REACT:R-CFA-5626681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of transition zone proteins (Canis familiaris)
REACT:R-MMU-5577237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNH2:KCNE transport K+ from cytosol to extracellular region (Mus musculus)
REACT:R-HSA-3065959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An unknown protease degrades hCBXs (Homo sapiens)
GO:0047613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-aconitate carboxy-lyase activity
GO:0047613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-aconitate carboxy-lyase (itaconate-forming)
GO:0047613	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CAD activity
GO:0047613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aconitate decarboxylase activity
GO:0047613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-aconitic decarboxylase activity
RHEA:60655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline
REACT:R-BTA-9661425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB dissociates (Bos taurus)
REACT:R-HSA-9606624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2 binds GAB2 (Homo sapiens)
REACT:R-XTR-9724753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds anti-fibrinolytics (Xenopus tropicalis)
REACT:R-SSC-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Sus scrofa)
REACT:R-SSC-8985929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Sus scrofa)
REACT:R-GGA-434053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to p-IRAK2 complexed with activated TLR (Gallus gallus)
RHEA:14150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP
REACT:R-CFA-5632649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds GAS1 and PTCH (Canis familiaris)
RHEA:42222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate
REACT:R-BTA-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Bos taurus)
REACT:R-GGA-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Gallus gallus)
REACT:R-SSC-5693539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of DNA and formation of Holliday structures following repair synthesis (Sus scrofa)
RHEA:24876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-D-serine <=> D-serine + phosphate
REACT:R-HSA-2172123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SIGLEC14/15/16 and DAP12 (Homo sapiens)
REACT:R-HSA-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
REACT:R-DME-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Drosophila melanogaster)
RHEA:57605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-169905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS is phosphorylated by active TrkA receptor (Bos taurus)
REACT:R-DRE-8952903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRHL2 hydrolyses poly(ADP-ribose) (Danio rerio)
REACT:R-XTR-9605600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Xenopus tropicalis)
RHEA:19563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + testololactone => androst-4-ene-3,17-dione + H(+) + NADPH + O2
REACT:R-DRE-420214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The adrenomedullin receptor can bind adrenomedullin and intermedin (Danio rerio)
RHEA:44639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitroanisole + H2O <=> 2,4-dinitrophenol + H(+) + methanol
RHEA:60775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 <=> 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate
REACT:R-CFA-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Canis familiaris)
REACT:R-XTR-9005980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 binds IL21R:JAK1 (Xenopus tropicalis)
RHEA:70203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyldopaminechrome = 5,6-dihydroxyindole-N-methyl
REACT:R-MMU-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Mus musculus)
RHEA:28572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-seryl-5'-AMP => ATP + L-serine
RHEA:27835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + succinate => a menaquinol + fumarate
REACT:R-MMU-6811479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 recruits EP300 to TP53 (Mus musculus)
RHEA:24039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-phosphate + ATP <=> a ribonucleoside 5'-diphosphate + ADP
RHEA:16082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-S-methyl-3-phospho-1-thioglycerate + H2O => (2R)-S-methyl-1-thioglycerate + phosphate
RHEA:16247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA
REACT:R-GGA-5654659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)
REACT:R-MMU-8987270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Mus musculus)
RHEA:67293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one
RHEA:54735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-DDI-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Dictyostelium discoideum)
RHEA:56322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP => a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose
RHEA:18368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate + NAD(+) <=> CO2 + NADH + pyruvate
REACT:R-GGA-9707586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM oxidises LDL,HDL (Gallus gallus)
REACT:R-SSC-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Sus scrofa)
GO:0005166	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin p75 receptor ligand
GO:0005166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotrophin p75 receptor binding
RHEA:28629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone => O2 + reduced [NADPH--hemoprotein reductase] + solavetivol
GO:0102980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity
RHEA:53501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
RHEA:43175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine
RHEA:64071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH
RHEA:51069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate => (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine
REACT:R-RNO-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Rattus norvegicus)
REACT:R-SSC-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Sus scrofa)
REACT:R-CEL-177939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
REACT:R-MMU-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-MMU-174587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Mus musculus)
REACT:R-XTR-5634750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Xenopus tropicalis)
EC:2.3.1.300	skos:prefLabel	"branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase"
EC:2.3.1.300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase"
REACT:R-HSA-9645535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 phosphorylates TIFA (Homo sapiens)
REACT:R-XTR-372519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcCho is hydrolyzed to Cho and acetate by ACHE (Xenopus tropicalis)
REACT:R-RNO-5638332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)
REACT:R-RNO-5340226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB dioxygenates NO (Rattus norvegicus)
REACT:R-RNO-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)
RHEA:15011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydrofolate + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + NADP(+)
REACT:R-MMU-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Mus musculus)
REACT:R-DME-8878143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SMAD3 and SMAD4 (Drosophila melanogaster)
RHEA:12119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2 <=> AH2
RHEA:40520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:63840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + tert-butyl hydroperoxide = [thioredoxin]-disulfide + H2O + tert-butanol
RHEA:71468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P => L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)
RHEA:25695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
RHEA:49367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) <=> 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate
GO:0034818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD 9alpha-hydroxylase activity
REACT:R-MMU-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Mus musculus)
RHEA:17029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin + H2O = allantoate + H(+)
RHEA:17029	skos:prefLabel	"allantoinase"
RHEA:17029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"allantoinase"
GO:0047359	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity
GO:0047359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-alkenyl-2-acylglycerol choline phosphotransferase"
GO:0047359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)
GO:0047359	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity
GO:0047359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkenyl-2-acylglycerol choline phosphotransferase activity
GO:0047359	skos:prefLabel	"1-alkenyl-2-acylglycerol choline phosphotransferase"
RHEA:62256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in)
REACT:R-SPO-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Schizosaccharomyces pombe)
RHEA:40602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
RHEA:18069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine = D-arginine
RHEA:18069	skos:prefLabel	"arginine racemase"
RHEA:18069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginine racemase"
RHEA:12931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-homocitrate + CoA + H(+) => 2-oxoglutarate + acetyl-CoA + H2O
REACT:R-HSA-4793956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective B4GALT1 does not add Gal to N-glycan (Homo sapiens)
REACT:R-MMU-422048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acyl Ghrelin and C-Ghrelin are secreted (Mus musculus)
REACT:R-RNO-1605724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Rattus norvegicus)
RHEA:30429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-RNO-3296233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T2Rs bind bitter-tasting compounds (Rattus norvegicus)
RHEA:26456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acryloyl-CoA + H(+) + NADPH => NADP(+) + propanoyl-CoA
REACT:R-CEL-9009309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STUB1 (Caenorhabditis elegans)
REACT:R-GGA-2730844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GRB2:SOS complex with p-SHC1 (Gallus gallus)
REACT:R-BTA-432909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Plectin with Integrin beta 4 (Bos taurus)
RHEA:66228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-C13-CoA + O2 = asc-DeltaC13-CoA + H2O2
REACT:R-RNO-2424486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)
REACT:R-DRE-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Danio rerio)
REACT:R-SSC-264865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin A (Sus scrofa)
REACT:R-HSA-9647660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds PIPs (Homo sapiens)
REACT:R-CFA-202709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 dimerises (Canis familiaris)
REACT:R-MMU-194678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 demethylates LNSOL (Mus musculus)
REACT:R-XTR-5694487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A4GNT transfers GlcNAc to core 2 mucins (Xenopus tropicalis)
REACT:R-XTR-194632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Xenopus tropicalis)
RHEA:23472	skos:prefLabel	"trehalose O-mycolyltransferase"
RHEA:23472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trehalose O-mycolyltransferase"
RHEA:23472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose
RHEA:15423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + AMP + diphosphate => a long-chain fatty acid + ATP + CoA
RHEA:69666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + luteolin 7-O-beta-D-glucoside <=> beta-D-glucose + luteolin
RHEA:45620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine
EC:3.4.24.77	skos:altLabel	"small neutral protease"
EC:3.4.24.77	skos:prefLabel	"snapalysin"
EC:3.4.24.77	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"snapalysin"
REACT:R-CFA-6782224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)
REACT:R-SPO-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Schizosaccharomyces pombe)
RHEA:22049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate
RHEA:68066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:59081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)
RHEA:48825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + Lc4Cer => a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)
REACT:R-XTR-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Xenopus tropicalis)
RHEA:36656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine => descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine
RHEA:41101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol
REACT:R-SSC-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Sus scrofa)
RHEA:45612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine
REACT:R-SSC-192434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of diacylglycerols by extracellular PTL:colipase (Sus scrofa)
REACT:R-GGA-8875661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA3 associates with activated MET receptor (Gallus gallus)
REACT:R-SPO-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Schizosaccharomyces pombe)
REACT:R-HSA-180739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex (Homo sapiens)
REACT:R-GGA-3928627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB phosphorylates TIAM1 (Gallus gallus)
RHEA:22385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + H(+) + phosphate
RHEA:67406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
GO:0018484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzaldehyde dehydrogenase activity
GO:0018484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybenzaldehyde:NAD+ oxidoreductase activity
GO:0018484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde dehydrogenase activity
REACT:R-SSC-936960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Sus scrofa)
RHEA:26529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O
RHEA:72619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate
RHEA:66483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenin + UDP-alpha-D-glucose <=> gypsogenin 28-beta-D-glucoside + UDP
RHEA:71653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide => a thymidine in DNA + NAD(+)
RHEA:70877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + L-methionine(in) + Na(+)(in) => L-glutamine(in) + L-methionine(out) + Na(+)(out)
REACT:R-CFA-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Canis familiaris)
RHEA:61949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate
REACT:R-MMU-392295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma recruits PI3K gamma (Mus musculus)
REACT:R-DRE-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Danio rerio)
RHEA:34728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a carboxylate
REACT:R-HSA-5696968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)
REACT:R-DRE-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Danio rerio)
REACT:R-SSC-174739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant + apoE => chylomicron remnant:apoE complex (Sus scrofa)
REACT:R-SSC-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Sus scrofa)
REACT:R-DME-109759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Drosophila melanogaster)
REACT:R-XTR-449976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)
RHEA:45281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-(phosphooxy)octadecanoate + H2O => 12-hydroxyoctadecanoate + phosphate
RHEA:46116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde + pyruvate
RHEA:31792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tuberculosinyl diphosphate => (13S)-edaxadiene + diphosphate
REACT:R-DDI-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Dictyostelium discoideum)
REACT:R-CEL-904864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Caenorhabditis elegans)
REACT:R-DME-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Drosophila melanogaster)
RHEA:37793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin Y + H2O2 => aclacinomycin A + O2
REACT:R-CFA-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Canis familiaris)
REACT:R-BTA-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Bos taurus)
RHEA:62571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-benzyl-L-cysteinylglycine <=> glycine + S-benzyl-L-cysteine
GO:0005161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFR binding
GO:0005161	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	platelet-derived growth factor receptor ligand
GO:0005161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	platelet-derived growth factor receptor binding
GO:0005161	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PDGF
GO:0005161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF receptor binding
GO:0005161	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	platelet-derived growth factor
GO:0047369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity
GO:0047369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutarate coenzyme A-transferase activity
GO:0047369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity
GO:0047369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate-hydroxymethylglutarate CoA-transferase activity
RHEA:43956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate
REACT:R-RNO-114261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-7 by the apoptosome (Rattus norvegicus)
REACT:R-MMU-8850831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates KLK8 (Mus musculus)
REACT:R-SSC-2396370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds collagens II, III and V (Sus scrofa)
REACT:R-CEL-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Caenorhabditis elegans)
RHEA:62792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + NADPH + O2 + 2 rubrofusarin B = 2 H2O + NADP(+) + nigerone
REACT:R-DDI-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Dictyostelium discoideum)
REACT:R-CFA-5138433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Canis familiaris)
REACT:R-XTR-5690870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Xenopus tropicalis)
RHEA:63381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine
REACT:R-HSA-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Homo sapiens)
REACT:R-MMU-1971483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Mus musculus)
REACT:R-RNO-9706344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates GRB10 (Rattus norvegicus)
REACT:R-SPO-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Schizosaccharomyces pombe)
RHEA:56147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + nitrate <=> a quinone + H2O + nitrite
GO:0004777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinate-semialdehyde dehydrogenase activity
GO:0004777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl semialdehyde dehydrogenase activity
GO:0004777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate-semialdehyde:NAD+ oxidoreductase activity
GO:0004777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate semialdehyde:NAD+ oxidoreductase activity
GO:0004777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinic semialdehyde dehydrogenase activity
GO:0004777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinate semialdehyde dehydrogenase activity
GO:0004777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate-semialdehyde dehydrogenase (NAD+) activity
REACT:R-XTR-4090390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates AR with SUMO1 (Xenopus tropicalis)
REACT:R-DME-6787757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates acidic AAs (Drosophila melanogaster)
REACT:R-XTR-69140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap (Xenopus tropicalis)
REACT:R-SSC-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Sus scrofa)
REACT:R-XTR-5656158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ elongates POLI-incorporated dNMP (Xenopus tropicalis)
RHEA:44810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-10 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+)
REACT:R-SSC-9033491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Sus scrofa)
REACT:R-CEL-5662692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is oxidized to dopaquinone by TYR (Caenorhabditis elegans)
REACT:R-BTA-72185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA polyadenylation (Bos taurus)
REACT:R-DRE-9013110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC binds effectors at the plasma membrane (Danio rerio)
REACT:R-MMU-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Mus musculus)
RHEA:65455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + hexanoyl-CoA <=> CoA + ethyl hexanoate
REACT:R-MMU-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Mus musculus)
REACT:R-SSC-2128994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Sus scrofa)
RHEA:11291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromacarpine + H(+) + O2 <=> H2O2 + macarpine
REACT:R-HSA-9705137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 or IKBKE forms homodimers (Homo sapiens)
REACT:R-RNO-9021072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC7, ZDHHC21 palmitoylate ESR1 (Rattus norvegicus)
RHEA:58458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O
REACT:R-CFA-4420107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHC-transforming protein 2 (Canis familiaris)
REACT:R-CFA-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Canis familiaris)
REACT:R-RNO-9727188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B binds PPIs (Rattus norvegicus)
REACT:R-MMU-981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3 convertases spontaneously dissociate (Mus musculus)
REACT:R-GGA-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Gallus gallus)
RHEA:51398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin
REACT:R-DDI-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Dictyostelium discoideum)
REACT:R-SSC-430190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds NCK (Sus scrofa)
RHEA:66259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + IC-asc-C7 <=> diphosphate + IC-asc-C7-AMP
RHEA:36208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA
RHEA:58836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:43983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + NADPH + O2 <=> 15-hydroxyhexadecanoate + H2O + NADP(+)
RHEA:60381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dehydroascorbate(out) => L-dehydroascorbate(in)
REACT:R-HSA-379994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)
REACT:R-MMU-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Mus musculus)
RHEA:34699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-isocomene synthase"
RHEA:34699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate
RHEA:34699	skos:prefLabel	"alpha-isocomene synthase"
RHEA:46463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Canis familiaris)
REACT:R-DDI-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Dictyostelium discoideum)
REACT:R-CFA-419490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATP to P2X receptors (Canis familiaris)
REACT:R-DRE-9624668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDKN1A (p21) (Danio rerio)
RHEA:62661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol => (2'R)-atrovenetin
REACT:R-DRE-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Danio rerio)
REACT:R-CFA-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Canis familiaris)
REACT:R-DRE-1358798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 binds neuregulin-activated ERBB3 (Danio rerio)
REACT:R-HSA-8939929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESRRA:PPARG1CA binds the RUNX2 gene promoter (Homo sapiens)
REACT:R-GGA-936986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)
RHEA:40580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-DRE-983145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Danio rerio)
RHEA:67463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate + A <=> AH2 + oxaloacetate
REACT:R-SPO-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Schizosaccharomyces pombe)
REACT:R-HSA-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Homo sapiens)
REACT:R-CFA-8876615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB13 GEFs exchange GTP for GDP on RAB13 (Canis familiaris)
REACT:R-MMU-6804942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 homodimers auto-ubiquitinate (Mus musculus)
RHEA:45891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-CFA-9714924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to soluble TNF trimer (Canis familiaris)
RHEA:42889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phosphomevalonate + ATP => (R)-3,5-bisphosphomevalonate + ADP + H(+)
RHEA:65789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-5357479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AXL binds PI3K (Danio rerio)
REACT:R-MMU-9679045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR9 dimer binds HCQ (Mus musculus)
REACT:R-RNO-9649108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer binds 5HT (Rattus norvegicus)
RHEA:46285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Drosophila melanogaster)
REACT:R-SCE-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Saccharomyces cerevisiae)
REACT:R-XTR-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Xenopus tropicalis)
RHEA:25305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)
RHEA:33232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + heme b => heme d cis-diol
REACT:R-XTR-6808487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)
GO:0047115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH
GO:0047115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-1,2-dihydrobenzene-1,2-diol dehydrogenase"
GO:0047115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0047115	skos:prefLabel	"trans-1,2-dihydrobenzene-1,2-diol dehydrogenase"
GO:0047115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity
GO:0047115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH
GO:0047115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrodiol dehydrogenase activity
REACT:R-GGA-1067651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Gallus gallus)
REACT:R-HSA-9756439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SNAI1 (Homo sapiens)
REACT:R-BTA-5229203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates histone H2A arginine-30 (H2AR29) (Bos taurus)
REACT:R-SSC-141040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Sus scrofa)
RHEA:57766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-4-nitrocatechol + NAD(+) + nitrite => 2,6-dinitrotoluene + NADH + O2
REACT:R-GGA-372717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)
GO:0031722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hemoglobin beta binding
REACT:R-BTA-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)
REACT:R-GGA-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Gallus gallus)
GO:0102727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxysteroid dehydrogenase activity
RHEA:42075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z)-2-oxohept-4-enedioate + H2O <=> (4S)-4-hydroxy-2-oxoheptanedioate
REACT:R-HSA-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Homo sapiens)
REACT:R-BTA-5695989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD11 dehydrogenates BH-CoA (Bos taurus)
REACT:R-RNO-9609310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β-blockers bind ADRB1,2,3 (Rattus norvegicus)
REACT:R-RNO-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Rattus norvegicus)
RHEA:17578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-glycero-beta-D-manno-heptose => ADP-L-glycero-beta-D-manno-heptose
REACT:R-BTA-176521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Bos taurus)
REACT:R-SSC-197268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)
REACT:R-CFA-2250301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyrrole cross-links (Canis familiaris)
REACT:R-HSA-5621888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HK1 does not phosphorylate Glc to form G6P (Homo sapiens)
REACT:R-RNO-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Rattus norvegicus)
RHEA:65794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-420977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca permeable AMPA receptor ligand binding (Gallus gallus)
RHEA:33042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Drosophila melanogaster)
RHEA:65044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cyanobenzyl alcohol + NAD(+) = 4-cyanobenzaldehyde + H(+) + NADH
REACT:R-DRE-6792871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNG1 recruits PP2A-PPP2R5C to MDM2 (Danio rerio)
REACT:R-CEL-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)
GO:0070856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin VI light chain binding
EC:3.4.22.-	skos:prefLabel	"Cysteine endopeptidases"
EC:3.4.22.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Cysteine endopeptidases"
RHEA:14144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + glutathione disulfide + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + 2 glutathione
REACT:R-HSA-9680262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)
RHEA:68178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dainate A + H2O + succinate => 2-oxoglutarate + N-geranyl-L-glutamate + O2
REACT:R-CEL-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Caenorhabditis elegans)
REACT:R-DDI-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Dictyostelium discoideum)
REACT:R-GGA-8931648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Gallus gallus)
RHEA:29145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + 2 H(+)(out) + H2O + nitrite => a ubiquinol + 2 H(+)(in) + nitrate
REACT:R-DME-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Drosophila melanogaster)
REACT:R-RNO-8866268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADBRK1,2 phosphorylate AVPR2 (Rattus norvegicus)
REACT:R-DME-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Drosophila melanogaster)
REACT:R-BTA-141341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMOX-3 oxidises SPN to SPM (Bos taurus)
RHEA:46107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> corticosterone + H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-5624127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome target cargo to the primary cilium (Rattus norvegicus)
RHEA:53088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-76054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Homo sapiens)
RHEA:34848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromonapterin + H(+) + NADPH => 5,6,7,8-tetrahydromonapterin + NADP(+)
REACT:R-HSA-5662692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is oxidized to dopaquinone by TYR (Homo sapiens)
RHEA:40932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ornithine + O2 => (3S)-3-hydroxy-L-ornithine + CO2 + succinate
RHEA:37580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-BTA-8850529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGS proteins bind GNB5 and CCT/TRiC (Bos taurus)
REACT:R-SSC-189208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Sus scrofa)
REACT:R-HSA-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
RHEA:10988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nitrous oxide = 2 e(-) + 2 H(+) + 2 nitric oxide
RHEA:45545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
RHEA:25438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,R)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-GGA-8952807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dissociates after IL12:IL12R interaction (Gallus gallus)
REACT:R-SSC-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Sus scrofa)
RHEA:41349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
REACT:R-HSA-8850797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK13 (Homo sapiens)
RHEA:71615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in)
GO:0004920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-10R
GO:0004920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-10 receptor activity
GO:0004920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-10 receptor activity
REACT:R-RNO-354124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
REACT:R-GGA-6786239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)
RHEA:42189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH
REACT:R-CEL-5666197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds LIN7B (Caenorhabditis elegans)
REACT:R-SSC-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Sus scrofa)
RHEA:70302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-dehydroascorbate <=> 2,3-dioxo-L-gulonate
RHEA:37628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:25717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Drosophila melanogaster)
REACT:R-HSA-6809785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR2 dimerizes (Homo sapiens)
RHEA:67321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate => sch 210971
RHEA:68996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A9 + O2 = CO2 + gibberellin A4 + succinate
REACT:R-RNO-983142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of peptide loading complex (PLC) (Rattus norvegicus)
REACT:R-CFA-164840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP and Pi bind to ATPase (Canis familiaris)
REACT:R-RNO-173542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 ubiquitinates SMAD2 (Rattus norvegicus)
REACT:R-BTA-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
REACT:R-HSA-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Homo sapiens)
RHEA:21469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-mycaminose + tylactone => 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)
REACT:R-CEL-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Caenorhabditis elegans)
RHEA:71488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Leu-enkephalin => L-phenylalanyl-L-leucine + L-tyrosylglycylglycine
RHEA:23031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] <=> acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]
RHEA:57519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
REACT:R-GGA-2187332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic CMs translocate to extracellular region (Gallus gallus)
REACT:R-DME-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Drosophila melanogaster)
RHEA:34871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol(out) = methanol(in)
REACT:R-CFA-8940554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2 cleaves OPTC (Canis familiaris)
REACT:R-SSC-2060328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS1 (Sus scrofa)
RHEA:34795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosyl 1,2-cyclic phosphate phosphodiesterase"
RHEA:34795	skos:prefLabel	"phosphoribosyl 1,2-cyclic phosphate phosphodiesterase"
RHEA:34795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = alpha-D-ribose 1,5-bisphosphate + H(+)
GO:0022835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter-gated channel activity
GO:0022835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmitter-gated channel activity
GO:0022835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular substance gated channel activity
RHEA:55684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + NH4(+) = 4-amino-4-deoxychorismate + H2O
REACT:R-HSA-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Homo sapiens)
REACT:R-MMU-2395314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysino-5-ketonorleucine cross-links (Mus musculus)
REACT:R-HSA-2537499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP19 (Homo sapiens)
RHEA:72983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + harmol = 6-(3-dimethylallyl)harmol + diphosphate
GO:0047850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-alpha,epsilon-diaminopimelate dehydrogenase activity
GO:0047850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diaminopimelate dehydrogenase activity
GO:0047850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-diaminopimelate dehydrogenase activity
GO:0047850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)
GO:0047850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-diaminopimelate D-dehydrogenase activity
RHEA:10016	skos:prefLabel	"sinapine esterase"
RHEA:10016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sinapine esterase"
RHEA:10016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-sinapoylcholine = (E)-sinapate + choline + H(+)
REACT:R-SSC-8876319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC50A1 transports Glc from cytosol to extracellular region (Sus scrofa)
REACT:R-SSC-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Sus scrofa)
RHEA:71015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methylputrescine + O2 = 4-methylaminobutanal + H2O2 + NH4(+)
RHEA:33439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + H2O + O2 = glyoxylate + H(+) + H2O2
REACT:R-DDI-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Dictyostelium discoideum)
RHEA:46770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-5195402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LPIN (Homo sapiens)
REACT:R-MMU-448702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-1 active tetramer formation (Mus musculus)
REACT:R-SCE-5668520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)
RHEA:32519	skos:altLabel	"2-methyl-GPP synthase"
RHEA:32519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranyl diphosphate 2-C-methyltransferase"
RHEA:32519	skos:altLabel	"GPP methyltransferase"
RHEA:32519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + S-adenosyl-L-methionine = (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine
RHEA:32519	skos:altLabel	"GPPMT"
RHEA:32519	skos:altLabel	"geranyl pyrophosphate methyltransferase"
RHEA:32519	skos:prefLabel	"geranyl diphosphate 2-C-methyltransferase"
RHEA:32519	skos:altLabel	"MGPPS"
GO:0050469	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sabinene hydrate cyclase activity
GO:0050469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sabinene-hydrate synthase activity
GO:0050469	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)
REACT:R-XTR-5683077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate KDM4A,B (Xenopus tropicalis)
RHEA:32491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32491	skos:altLabel	"CYP71BA1"
RHEA:32491	skos:prefLabel	"alpha-humulene 10-hydroxylase"
RHEA:32491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-humulene 10-hydroxylase"
REACT:R-BTA-8854905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)
RHEA:46757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-427514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC deacetylates histone H3 (Bos taurus)
REACT:R-HSA-5609665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
RHEA:24291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formimidoyltetrahydrofolate + glycine <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine
REACT:R-GGA-8857577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 facilitates PTK6 autophosphorylation (Gallus gallus)
RHEA:62332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ATP = adenosine 3'-diphosphate,5'-diphosphate + AMP
RHEA:54081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine
REACT:R-DRE-9701488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates JAK3 (Danio rerio)
REACT:R-CFA-192434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of diacylglycerols by extracellular PTL:colipase (Canis familiaris)
RHEA:16676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphonopyruvate + H2O <=> H(+) + phosphate + pyruvate
REACT:R-DME-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Drosophila melanogaster)
RHEA:14808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-allose <=> ADP + D-allose 6-phosphate + H(+)
REACT:R-DRE-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Danio rerio)
RHEA:57362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-NADHX => H2O + NADH
REACT:R-RNO-2424487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)
REACT:R-BTA-211904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F12 18-hydroxylates ARA (Bos taurus)
REACT:R-GGA-203774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Csk with PAG (Gallus gallus)
REACT:R-XTR-449058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family are secreted (Xenopus tropicalis)
RHEA:38594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine <=> chloroorienticin B + dTDP + H(+)
REACT:R-GGA-444126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Gallus gallus)
RHEA:14222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monomethyl sulfate => H(+) + methanol + sulfate
RHEA:57749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH => C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
EC:3.4.22.16	skos:altLabel	"aleurain"
EC:3.4.22.16	skos:altLabel	"N-benzoylarginine-beta-naphthylamide hydrolase"
EC:3.4.22.16	skos:altLabel	"cathepsin BA"
EC:3.4.22.16	skos:altLabel	"cathepsin B3"
EC:3.4.22.16	skos:prefLabel	"cathepsin H"
EC:3.4.22.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin H"
REACT:R-HSA-175177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  XRCC4:DNA ligase IV complex with viral DNA ends (Homo sapiens)
RHEA:69467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine <=> 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:39971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate = 2-aminobut-2-enoate
REACT:R-BTA-8876366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL translocates from endosome lumen to lysosome lumen (Bos taurus)
RHEA:63798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O
REACT:R-MMU-421426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ProGIP translocates from the ER Lumen to secretory granules (Mus musculus)
RHEA:62196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + propan-2-ol = acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-DRE-909719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STAT2 to p-IFNAR1 (Danio rerio)
GO:0030342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
GO:0030342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol 24-hydroxylase activity
GO:0030342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25-(OH)2D3 24-hydroxylase activity
REACT:R-GGA-4341048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RXRA with SUMO1 (Gallus gallus)
RHEA:29701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide(out) => dimethyl sulfoxide(in)
REACT:R-XTR-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)
RHEA:53033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-SSC-9707586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM oxidises LDL,HDL (Sus scrofa)
RHEA:59278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamine => L-glutamine
RHEA:36532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA => (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA
REACT:R-HSA-9012186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD1 translation is negatively regulated by miR-26A and B (Homo sapiens)
REACT:R-CFA-9005995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the SIN3A co-repressor complex (Canis familiaris)
RHEA:55431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-73632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Sus scrofa)
REACT:R-DRE-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Danio rerio)
RHEA:41296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(hexanoyl)sphing-4-enine => hexanoate + sphing-4-enine
REACT:R-HSA-8961961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the CDC25A gene promoter (Homo sapiens)
RHEA:70876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-methionine(out) + Na(+)(out) => L-glutamine(out) + L-methionine(in) + Na(+)(in)
REACT:R-HSA-5665727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds CDC42:GTP (Homo sapiens)
REACT:R-CFA-6813740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDE1 hydrolyzes GroPIns (Canis familiaris)
REACT:R-CFA-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Canis familiaris)
REACT:R-DME-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Drosophila melanogaster)
RHEA:52064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)
REACT:R-HSA-9694294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E pentamer is transported to the Golgi (Homo sapiens)
GO:0019146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoarabinoisomerase activity
GO:0019146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinose-5-phosphate ketol-isomerase activity
GO:0019146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinose-5-phosphate isomerase activity
GO:0019146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinose-5-phosphate aldose-ketose-isomerase activity
GO:0019146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arabinose phosphate isomerase activity
REACT:R-BTA-5654397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS2 (Bos taurus)
RHEA:29036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamate(out) => ADP + H(+) + L-glutamate(in) + phosphate
REACT:R-SSC-2130641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TGN-lysosome vesicle to lysosome (Sus scrofa)
REACT:R-HSA-5638157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)
REACT:R-HSA-5649673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyA from damaged DNA (Homo sapiens)
RHEA:67805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 => CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate
GO:0036408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K14 acetyltransferase activity
GO:0036408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H3-K14 specific)
GO:0036408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H3-K14 specific)
GO:0036408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K14 acetyltransferase activity
GO:0036408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H3-K14 specific)
REACT:R-GGA-9603420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 promotes SRC autophosphorylation (Gallus gallus)
RHEA:11492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2
RHEA:11492	skos:altLabel	"L-threonine-O-3-phosphate decarboxylase"
RHEA:11492	skos:prefLabel	"threonine-phosphate decarboxylase"
RHEA:11492	skos:altLabel	"L-threonine O-3-phosphate carboxy-lyase"
RHEA:11492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"threonine-phosphate decarboxylase"
GO:0032406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MutLbeta complex binding
RHEA:62851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
RHEA:32218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-NADHX <=> (6S)-NADHX
REACT:R-CFA-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Canis familiaris)
REACT:R-HSA-8851933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates GAB1 (Homo sapiens)
REACT:R-XTR-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Xenopus tropicalis)
RHEA:37359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucosamine 6-phosphate(in) + L-histidyl-[protein]
RHEA:22033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxalomalate => glyoxylate + oxaloacetate
RHEA:47164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxyzymosterol + NAD(+) = CO2 + NADH + zymosterone
RHEA:22653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate
RHEA:65103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerol + hexadecanoyl-CoA <=> an hexadecanoyl-acylglycerol + CoA
RHEA:17624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + citramalate <=> (3S)-citramalyl-CoA + acetate
RHEA:59812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]
RHEA:45264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)
RHEA:20260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyloxindole + NADP(+) <=> 3-methyleneoxindole + H(+) + NADPH
REACT:R-DRE-9706345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Danio rerio)
RHEA:18702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite + H2O + 2 oxidized [azurin] => arsenate + 3 H(+) + 2 reduced [azurin]
REACT:R-CFA-9648089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6 and NEK7 phosphorylate EML4 (Canis familiaris)
REACT:R-DME-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Drosophila melanogaster)
REACT:R-BTA-6811414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF (Bos taurus)
RHEA:15337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate
RHEA:15337	skos:prefLabel	"phenylacetyl-CoA hydrolase"
RHEA:15337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetyl-CoA hydrolase"
REACT:R-CEL-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Caenorhabditis elegans)
REACT:R-HSA-2473511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XXIII binds Integrin alpha2beta1 (Homo sapiens)
REACT:R-XTR-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Xenopus tropicalis)
RHEA:56032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)
REACT:R-HSA-5610726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The IFT-A complex recruits TULP3 (Homo sapiens)
REACT:R-HSA-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Homo sapiens)
RHEA:32762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine <=> (3R)-3-methyl-D-ornithine
RHEA:59172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] = AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]
REACT:R-RNO-5607721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NIK (Rattus norvegicus)
RHEA:28293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (5S,9S,10S)-drim-7-en-11-ol + diphosphate
RHEA:57584	skos:altLabel	"CYP93G2"
RHEA:57584	skos:prefLabel	"flavanone 2-hydroxylase"
RHEA:57584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57584	skos:altLabel	"CYP93B1"
RHEA:57584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavanone 2-hydroxylase"
REACT:R-BTA-158118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Bos taurus)
REACT:R-HSA-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Homo sapiens)
REACT:R-GGA-265867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RPA-heterotrimer (Gallus gallus)
REACT:R-DRE-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Danio rerio)
RHEA:54217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O
REACT:R-RNO-9707690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 binds MAFK (Rattus norvegicus)
RHEA:42790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine
REACT:R-CEL-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Caenorhabditis elegans)
REACT:R-BTA-9691215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFR2 dimer (Bos taurus)
REACT:R-GGA-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Gallus gallus)
REACT:R-DME-68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated geminin is degraded by the proteasome (Drosophila melanogaster)
GO:0047295	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity
GO:0047295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranylglycerol-phosphate geranylgeranyltransferase activity
GO:0047295	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyltransferase II
GO:0047295	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity
RHEA:33961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'''-deamino-6'''-oxoneomycin C + L-glutamate => 2-oxoglutarate + neomycin C
RHEA:59798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-DRE-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Danio rerio)
REACT:R-DDI-9020264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)
RHEA:53580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:54252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
RHEA:50566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein]
RHEA:12417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-CoA => acryloyl-CoA + NH4(+)
REACT:R-SSC-5635861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH binds GLI1 (Sus scrofa)
REACT:R-RNO-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Rattus norvegicus)
REACT:R-MMU-419334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melatonin receptors can bind melatonin (Mus musculus)
RHEA:10268	skos:altLabel	"2-keto-3-deoxyglucarate aldolase"
RHEA:10268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate
RHEA:10268	skos:prefLabel	"2-dehydro-3-deoxyglucarate aldolase"
RHEA:10268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxyglucarate aldolase"
RHEA:10268	skos:altLabel	"2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase"
RHEA:10268	skos:altLabel	"alpha-keto-beta-deoxy-D-glucarate aldolase"
REACT:R-DME-211224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with DFF45 (Drosophila melanogaster)
REACT:R-DME-5654409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS2 (Drosophila melanogaster)
RHEA:32009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + isopimara-8(14),15-diene => 9alpha-copalyl diphosphate
REACT:R-MMU-5696021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPGK:Mg2+ phosphorylates Glc to G6P (Mus musculus)
RHEA:42986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + pimara-8(14),15-diene => (+)-copalyl diphosphate
RHEA:21039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA
RHEA:22173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + UDP-alpha-D-glucose => H(+) + sucrose 6(F)-phosphate + UDP
REACT:R-HSA-1799329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)
REACT:R-MMU-8937113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Mus musculus)
EC:3.1.6.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronate-2-sulfatase"
EC:3.1.6.18	skos:altLabel	"chondro-2-sulfatase"
EC:3.1.6.18	skos:prefLabel	"glucuronate-2-sulfatase"
REACT:R-DRE-210426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamate synaptic vesicle docking and priming (Danio rerio)
RHEA:28237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate 5-semialdehyde <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O
RHEA:19702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-glycoside + UDP-alpha-D-xylose => a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP
GO:0090416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate transmembrane transporter activity
GO:0090416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A13 transports NCA from extracellular region to cytosol (Homo sapiens)
REACT:R-XTR-5225649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP7 binds histone H3 (Xenopus tropicalis)
REACT:R-HSA-727819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 phosphorylates MKK6 (Homo sapiens)
REACT:R-DME-8956684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH polyubiquitinates TP73 (Drosophila melanogaster)
REACT:R-HSA-419001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Homo sapiens)
REACT:R-HSA-9033959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Homo sapiens)
REACT:R-MMU-936802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)
RHEA:46804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine = a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine
RHEA:46804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingolipid C(9)-methyltransferase"
RHEA:46804	skos:prefLabel	"sphingolipid C(9)-methyltransferase"
RHEA:54846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl butanoate + H2O + NADP(+) => H(+) + hexan-3-one + NADPH + O2
RHEA:62977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienamide + H2O => (9Z,12Z,15Z)-octadecatrienoate + NH4(+)
RHEA:49155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine
RHEA:33985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + miltiradiene => (+)-copalyl diphosphate
REACT:R-HSA-2028735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind WWTR1 (TAZ) (Homo sapiens)
GO:0018475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
REACT:R-BTA-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Bos taurus)
REACT:R-CEL-193736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)
REACT:R-BTA-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
REACT:R-RNO-5638009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Rattus norvegicus)
REACT:R-DRE-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Danio rerio)
GO:0015292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uniporter activity
GO:0015292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-species transporter activity
GO:0015292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	facilitated diffusion carrier
GO:0015292	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uniport
REACT:R-MMU-351849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Etk (Mus musculus)
GO:0061769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosylnicotinate kinase activity
REACT:R-DRE-5654397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS2 (Danio rerio)
REACT:R-RNO-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Rattus norvegicus)
RHEA:25105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyridoxamine => ADP + H(+) + pyridoxamine 5'-phosphate
REACT:R-RNO-373358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR6 binds CXCL16 ligand (Rattus norvegicus)
RHEA:32624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
RHEA:26113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine
REACT:R-DRE-870437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) deubiquitinates SMAD4 (Danio rerio)
REACT:R-DRE-445113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Urotensin-2 receptor binds urotensin-2 and 2B (Danio rerio)
REACT:R-GGA-166792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C2 into C2a and C2b (Gallus gallus)
REACT:R-XTR-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Xenopus tropicalis)
REACT:R-MMU-4793925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S303,307-HSF1 binds YWHAE (14-3-3) (Mus musculus)
RHEA:14842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => ent-copalyl diphosphate
REACT:R-SSC-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Sus scrofa)
REACT:R-SPO-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Schizosaccharomyces pombe)
REACT:R-HSA-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Homo sapiens)
REACT:R-BTA-448963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of MyoD:E protein with MEF2 (Bos taurus)
RHEA:51621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + formate + H(+) => CO2 + dCTP + H2O
REACT:R-MMU-2025890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds NFATC1,2,3 (Mus musculus)
REACT:R-DME-183084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)
REACT:R-BTA-8876472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 binds CHOL (Bos taurus)
REACT:R-SSC-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Sus scrofa)
RHEA:46373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:20350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene => 2-hydroxytoluene + H2O + NAD(+)
REACT:R-RNO-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Rattus norvegicus)
RHEA:33467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydroepisterol + H(+) + NADPH + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)
RHEA:33467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sterol 22-desaturase"
RHEA:33467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + sitosterol = 2 H2O + NADP(+) + stigmasterol
RHEA:33467	skos:prefLabel	"sterol 22-desaturase"
REACT:R-MMU-170072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Mus musculus)
RHEA:64468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) = 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH
RHEA:67753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
RHEA:33953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP => ribostamycin + UDP-N-acetyl-alpha-D-glucosamine
RHEA:42837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH => 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)
RHEA:32484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + pheophorbide a => CO2 + methanol + pyropheophorbide a
REACT:R-CFA-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Canis familiaris)
REACT:R-SSC-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Sus scrofa)
RHEA:72884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-phenylpyruvate + 2 ATP => 2 AMP + 2 diphosphate + H(+) + polyporic acid
RHEA:72782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + O2 + ochratoxin B <=> FAD + 2 H2O + ochratoxin A
RHEA:12973	skos:altLabel	"adenylic kinase"
RHEA:12973	skos:altLabel	"adenylokinase"
RHEA:12973	skos:prefLabel	"adenylate kinase"
RHEA:12973	skos:altLabel	"myokinase"
RHEA:12973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP = 2 ADP
RHEA:12973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylate kinase"
REACT:R-MMU-211924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4B1 12-hydroxylates ARA (Mus musculus)
GO:0047814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinokinase activity
GO:0047814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-arabinose 5-phosphotransferase activity
GO:0047814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinokinase (phosphorylating)
REACT:R-HSA-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Homo sapiens)
EC:3.2.1.35	skos:altLabel	"chondroitinase"
EC:3.2.1.35	skos:prefLabel	"hyaluronoglucosaminidase"
EC:3.2.1.35	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hyaluronoglucosaminidase"
EC:3.2.1.35	skos:altLabel	"chondroitinase I"
EC:3.2.1.35	skos:altLabel	"hyaluronidase"
EC:3.2.1.35	skos:altLabel	"hyaluronoglucosidase"
REACT:R-XTR-8869456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP4 deubiquitinate TRAF2,TRAF6 (Xenopus tropicalis)
REACT:R-CEL-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)
RHEA:39724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol(in) => a 1,2-diacyl-sn-glycerol(out)
REACT:R-XTR-375768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Xenopus tropicalis)
RHEA:29200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + menaquinone-8 => menaquinol-8 + orotate
REACT:R-CFA-5666001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Profilin:G-actin binds MKL1 (Canis familiaris)
RHEA:44122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + octadecanyl hexadecanoate => hexadecanoyl-CoA + octadecan-1-ol
REACT:R-DDI-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Dictyostelium discoideum)
REACT:R-SSC-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Sus scrofa)
REACT:R-DRE-5668543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3:NIK binds TRAF2:cIAP1/2 (Danio rerio)
REACT:R-RNO-174786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Rattus norvegicus)
REACT:R-HSA-141200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates of PEA (Homo sapiens)
RHEA:57361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADH => (6R)-NADHX
REACT:R-CFA-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Canis familiaris)
REACT:R-SPO-4570493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Schizosaccharomyces pombe)
RHEA:40957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CO2 + isopentenyl phosphate + phosphate => (R)-5-phosphomevalonate + ATP
RHEA:20095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + UDP => an anthocyanidin + H(+) + UDP-alpha-D-glucose
RHEA:71718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-leucyl-L-leucine(out) <=> H(+)(in) + L-leucyl-L-leucine(in)
REACT:R-MMU-4641350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TOP2A with SUMO2,3 (Mus musculus)
REACT:R-SSC-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Sus scrofa)
REACT:R-RNO-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Rattus norvegicus)
REACT:R-RNO-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Rattus norvegicus)
REACT:R-CEL-9624112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK4 (Caenorhabditis elegans)
REACT:R-HSA-4420107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHC-transforming protein 2 (Homo sapiens)
GO:0051474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosylglycerol transmembrane transporter activity
GO:0043423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3-phosphate-dependent protein kinase binding
GO:0043423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoinositide-dependent protein kinase binding
REACT:R-SSC-9018858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Sus scrofa)
RHEA:30728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + pyruvate => dADP + H(+) + phosphoenolpyruvate
REACT:R-CFA-450499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B (AKT) phosphorylates KSRP (Canis familiaris)
GO:0047941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronolactone reductase activity
REACT:R-HSA-193677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRIF binds to p75NTR (Homo sapiens)
RHEA:13098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] => a (2E)-enoyl-[ACP] + H2O
RHEA:27867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + alpha-D-mannose 6-phosphate
GO:0052807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aflatoxin:coenzyme F420 oxidoreductase activity
GO:0052807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-aflatoxin reductase activity
GO:0052807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aflatoxin reductase (coenzyme F420) activity
GO:0052807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aflatoxin:reduced coenzyme F420 reductase activity
GO:0052807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent aflatoxin reductase activity
REACT:R-BTA-352268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Satb1 (Bos taurus)
RHEA:56206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]
RHEA:40554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylphylloquinol + S-adenosyl-L-methionine <=> H(+) + phylloquinol + S-adenosyl-L-homocysteine
REACT:R-BTA-9611851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 bind ADR,NAd (Bos taurus)
RHEA:37885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + oxalyl-CoA => acetyl-CoA + oxalate
RHEA:68795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-NAD(+) + H2O <=> ADP-D-ribose + H(+) + nicotinamide
REACT:R-DDI-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Dictyostelium discoideum)
REACT:R-CFA-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Canis familiaris)
RHEA:63885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + L-tyrosine => H2O + L-dopa
RHEA:71293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + chloride(in) + 2 Na(+)(in) => (R)-carnitine(out) + chloride(out) + 2 Na(+)(out)
REACT:R-DDI-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Dictyostelium discoideum)
REACT:R-CFA-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)
RHEA:38933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O
REACT:R-MMU-917933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Mus musculus)
REACT:R-RNO-5675656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA:EDAR binds EDARADD (Rattus norvegicus)
REACT:R-GGA-5632738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDIT4 binds 14-3-3 dimer (Gallus gallus)
REACT:R-SSC-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Sus scrofa)
REACT:R-SCE-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Saccharomyces cerevisiae)
RHEA:50844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
REACT:R-DME-209076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPZ dimer bound TL dimerises at the plasma membrane (Drosophila melanogaster)
REACT:R-XTR-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Xenopus tropicalis)
RHEA:68042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+) => (R)-lanthionine ketimine + 2 H(+) + NADPH
GO:0038164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombopoietin receptor activity
GO:0050815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoserine binding
GO:0050815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoserine residue binding
GO:0001727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid kinase activity
GO:0102669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoflavone-7-O-glucoside beta-glucosidase activity
REACT:R-GGA-353444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Gallus gallus)
REACT:R-CFA-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Canis familiaris)
RHEA:50839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate
REACT:R-CEL-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
RHEA:58412	skos:prefLabel	"L-aspartate semialdehyde sulfurtransferase"
RHEA:58412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] = H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]
RHEA:58412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-aspartate semialdehyde sulfurtransferase"
RHEA:68554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine
REACT:R-DME-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Drosophila melanogaster)
REACT:R-DDI-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Dictyostelium discoideum)
REACT:R-XTR-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Xenopus tropicalis)
REACT:R-RNO-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Rattus norvegicus)
RHEA:10948	skos:altLabel	"hexokinase type II"
RHEA:10948	skos:prefLabel	"glucosamine kinase"
RHEA:10948	skos:prefLabel	"hexokinase"
RHEA:10948	skos:altLabel	"hexokinase type I"
RHEA:10948	skos:altLabel	"hexokinase type III"
RHEA:10948	skos:altLabel	"hexokinase type IV (glucokinase)"
RHEA:10948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosamine kinase"
RHEA:10948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+)
RHEA:10948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hexokinase"
REACT:R-HSA-5662617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1G binds cadmium (Homo sapiens)
RHEA:57634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase] => ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-373724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds NCK (Mus musculus)
RHEA:18976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + deacetoxyvindoline + O2 <=> 4-O-deacetylvindoline + CO2 + succinate
REACT:R-DRE-1470010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs (Danio rerio)
REACT:R-SSC-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Sus scrofa)
REACT:R-HSA-2046101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoA (Homo sapiens)
REACT:R-MMU-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Mus musculus)
REACT:R-RNO-2396594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
RHEA:66451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-pent-2-en-1-ol + NADP(+) <=> (E)-2-pentenal + H(+) + NADPH
RHEA:56838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine => [PQQ precursor protein] + S-adenosyl-L-methionine
REACT:R-PFA-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Plasmodium falciparum)
REACT:R-DRE-1604722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP9 by proteases (Danio rerio)
GO:0102042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroquinate synthase activity
RHEA:35048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-molybdopterin + H(+) + molybdate => AMP + H2O + Mo-molybdopterin
REACT:R-MMU-9669893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type I TKIs (Mus musculus)
RHEA:52592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholoyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH
RHEA:52592	skos:prefLabel	"3alpha-hydroxybile acid CoA 3-dehydrogenase"
RHEA:52592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha-hydroxybile acid CoA 3-dehydrogenase"
REACT:R-HSA-1791102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of C19orf10 (Homo sapiens)
REACT:R-SSC-211919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F8 19-hydroxylates PGH2 (Sus scrofa)
REACT:R-GGA-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Gallus gallus)
RHEA:59257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-enterobactin + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)
REACT:R-RNO-190261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3c binds to FGF (Rattus norvegicus)
RHEA:22954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenedioyl-CoA + H2O2 => O2 + octanedioyl-CoA
REACT:R-SSC-8932955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Sus scrofa)
RHEA:56662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)
REACT:R-SCE-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Saccharomyces cerevisiae)
REACT:R-MMU-352108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Mus musculus)
REACT:R-CFA-5662613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 exchanges zinc for copper (Canis familiaris)
REACT:R-HSA-3927824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
REACT:R-RNO-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Rattus norvegicus)
REACT:R-HSA-2066782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of DPA to the ER (Homo sapiens)
REACT:R-DME-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Drosophila melanogaster)
RHEA:29794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(out) + H2O <=> ADP + glutathione(in) + H(+) + phosphate
RHEA:31417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-2-epi-prezizaene + diphosphate => (2Z,6E)-farnesyl diphosphate
RHEA:41436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z-octadecenoate) + CoA
REACT:R-CEL-6803789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Caenorhabditis elegans)
RHEA:27726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate
REACT:R-DME-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Drosophila melanogaster)
RHEA:63674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH
REACT:R-DME-3858495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits GTP-bound RHOA (Drosophila melanogaster)
RHEA:57078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + glycolate + H(+) => 3-oxoisoapionate 4-phosphate + H2O
REACT:R-HSA-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Homo sapiens)
RHEA:70683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-normetanephrine + S-adenosyl-L-methionine = (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Rattus norvegicus)
REACT:R-XTR-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Xenopus tropicalis)
RHEA:63420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyethylphosphonate cytidylyltransferase"
RHEA:63420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate
RHEA:63420	skos:prefLabel	"2-hydroxyethylphosphonate cytidylyltransferase"
REACT:R-XTR-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Xenopus tropicalis)
RHEA:28770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylnitronate + O2 <=> acetaldehyde + chemical entity + H(+) + nitrite
REACT:R-MMU-9691421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK binds BTK inhibitors (Mus musculus)
GO:0031736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR11 chemokine receptor binding
GO:0031736	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR11 chemokine receptor ligand
REACT:R-BTA-193743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
RHEA:33254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 sucrose <=> 6-kestotriose + beta-D-glucose
REACT:R-HSA-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)
GO:0004791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:oxidized thioredoxin oxidoreductase activity
GO:0004791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP--thioredoxin reductase activity
GO:0004791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2:oxidized thioredoxin oxidoreductase activity
GO:0004791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thioredoxin:NADP+ oxidoreductase activity
GO:0004791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH--thioredoxin reductase activity
GO:0004791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin disulfide reductase activity
GO:0004791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin-disulphide reductase activity
GO:0004791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin-disulfide reductase activity
GO:0004791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin reductase (NADPH) activity
RHEA:13971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP => a 3'-end 3'-phospho-ribonucleotide-RNA + GTP
REACT:R-HSA-1655879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiosulfate can transfer its sulfur atom to glutathione (Homo sapiens)
REACT:R-CFA-5334794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABPs bind LCFAs (Canis familiaris)
REACT:R-CFA-174739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant + apoE => chylomicron remnant:apoE complex (Canis familiaris)
RHEA:16621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + H(+) + O2 = H2O2 + sanguinarine
REACT:R-BTA-390251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Bos taurus)
RHEA:57272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA
REACT:R-CFA-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Canis familiaris)
REACT:R-MMU-5654597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Mus musculus)
REACT:R-CFA-5621347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)
RHEA:28342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dITP + H2O = dIMP + diphosphate + H(+)
RHEA:38742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol
RHEA:20203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + D-phenylalanine + diphosphate + H(+) => ATP + H2O + L-phenylalanine
RHEA:49352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:36356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine
REACT:R-RNO-74737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)
RHEA:69113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-2-aminoadipate => 2-oxoadipate + glycine
REACT:R-XTR-209924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is decarboxylated to dopamine (Xenopus tropicalis)
RHEA:71901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide => 3',5'-cyclic GMP + NAD(+)
RHEA:57513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorobenzene + H(+) + NADH + O2 => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)
RHEA:50455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H3 <=> prostaglandin E3
REACT:R-HSA-5626962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB2L1 binds IKKA:IKKB:NEMO (Homo sapiens)
RHEA:50279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate
REACT:R-HSA-9729730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 nsp3 cleaves IRF3 (Homo sapiens)
RHEA:52043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine <=> 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine
REACT:R-XTR-2002466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of allysine by LOX (Xenopus tropicalis)
REACT:R-HSA-3000122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD320 binds extracellular TCN2:RCbl (Homo sapiens)
RHEA:49215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
REACT:R-DRE-373074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR9  binds CCL25 ligand (Danio rerio)
REACT:R-HSA-3601585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
RHEA:16497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:16497	skos:prefLabel	"23S rRNA (adenine(1618)-N(6))-methyltransferase"
RHEA:16497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (adenine(1618)-N(6))-methyltransferase"
RHEA:16497	skos:altLabel	"rRNA large subunit methyltransferase F"
RHEA:57366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADHX => H2O + NADH
RHEA:32477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine => glycine + 3 S-adenosyl-L-methionine
RHEA:64969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUDP + H(+) + phosphate
RHEA:19399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + CTP + L-cysteine
RHEA:66208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-8-hydroxynonanoyl-CoA + O2 = (2E,8R)-8-hydroxynonenoyl-CoA + H2O2
RHEA:46099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + dihydropinosylvin
REACT:R-GGA-83791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Gallus gallus)
GO:0102151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-myristate decarboxylase activity
RHEA:43952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate
REACT:R-GGA-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Gallus gallus)
REACT:R-CEL-5661290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Caenorhabditis elegans)
RHEA:56144	skos:altLabel	"quinol-nitrate oxidoreductase"
RHEA:56144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrate reductase (quinone)"
RHEA:56144	skos:altLabel	"quinol/nitrate oxidoreductase"
RHEA:56144	skos:prefLabel	"nitrate reductase (quinone)"
RHEA:56144	skos:altLabel	"dissimilatory nitrate reductase"
RHEA:56144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + nitrate = a quinone + H2O + nitrite
RHEA:56144	skos:altLabel	"nitrate reductase Z"
RHEA:56144	skos:altLabel	"nitrate reductase A"
REACT:R-CFA-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Canis familiaris)
RHEA:28320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scutellarin + UDP => scutellarein + UDP-alpha-D-glucuronate
REACT:R-MMU-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Mus musculus)
REACT:R-RNO-201521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK autophosphorylation downstream of PTN and MDK (Rattus norvegicus)
REACT:R-SSC-391377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone receptor can bind LH (Sus scrofa)
RHEA:25069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH
REACT:R-BTA-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Bos taurus)
RHEA:59782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => L-histidine + S-adenosyl-L-methionine
REACT:R-HSA-9705323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TBK1/IKBKE (Homo sapiens)
REACT:R-HSA-8956234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translation of DCUN1D3 is inhibited by PUM2 (Homo sapiens)
REACT:R-GGA-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
RHEA:26159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose + NADP(+) <=> D-glucosone + H(+) + NADPH
RHEA:60013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA with a 3' CC end + ATP => a tRNA with a 3' CCA end + diphosphate
REACT:R-CFA-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Canis familiaris)
RHEA:25138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + pyridoxamine <=> H2O + pyridoxamine 5'-phosphate
RHEA:10381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + orotidine 5'-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + orotate
RHEA:29937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine(out) + H(+)(out) => cytosine(in) + H(+)(in)
REACT:R-GGA-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Gallus gallus)
GO:0102308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin D 3''-o-methyltransferase activity
REACT:R-HSA-110360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to the AP site (Homo sapiens)
REACT:R-CEL-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Caenorhabditis elegans)
RHEA:46947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) <=> H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH
GO:0032576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-linoleoyltransferase activity
RHEA:57112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:68091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] <=> a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]
RHEA:70038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol
REACT:R-HSA-1225947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)
REACT:R-DRE-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Danio rerio)
REACT:R-SPO-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Schizosaccharomyces pombe)
REACT:R-SSC-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Sus scrofa)
RHEA:69198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[beta-tubulin]
REACT:R-SSC-909724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IFNAR1 (Sus scrofa)
REACT:R-SSC-5082384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70:DNAJB1 binds HSF1 (Sus scrofa)
REACT:R-SPO-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Schizosaccharomyces pombe)
REACT:R-RNO-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Rattus norvegicus)
REACT:R-HSA-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Homo sapiens)
RHEA:34971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(3+)(in) = Fe(3+)(out)
REACT:R-CFA-349603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Canis familiaris)
RHEA:20772	skos:prefLabel	"riboflavin synthase"
RHEA:20772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin
RHEA:20772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"riboflavin synthase"
RHEA:40416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)
REACT:R-MMU-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Mus musculus)
REACT:R-GGA-517850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR2-1 : TLR1-2 heterodimer binds to its ligand (Gallus gallus)
REACT:R-XTR-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Xenopus tropicalis)
REACT:R-DME-1676149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Drosophila melanogaster)
REACT:R-GGA-1296127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of voltage gated Potassium channels (Gallus gallus)
REACT:R-HSA-5333615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)
REACT:R-XTR-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Xenopus tropicalis)
RHEA:58163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate <=> diphosphate + dolabradiene
REACT:R-CFA-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Canis familiaris)
RHEA:59104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)
REACT:R-BTA-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)
REACT:R-XTR-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Xenopus tropicalis)
REACT:R-GGA-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Gallus gallus)
REACT:R-BTA-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Bos taurus)
REACT:R-HSA-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Homo sapiens)
RHEA:19262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + heme b(in) => ADP + H(+) + heme b(out) + phosphate
GO:1901479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benomyl transmembrane transporter activity
GO:1901479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benomyl transporter activity
REACT:R-RNO-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Rattus norvegicus)
REACT:R-BTA-1549564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPTN11 dephosphorylates SPRY2 (Bos taurus)
RHEA:67426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+) => a glycerophospholipid + H2O
REACT:R-GGA-5610735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB binds ITCH (Gallus gallus)
REACT:R-HSA-5632914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the GLS2 promoter (Homo sapiens)
RHEA:62836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine
RHEA:52401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-D-threonate + NAD(+) => 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH
REACT:R-BTA-2160932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 binds phosphorylated PARD6A (Bos taurus)
REACT:R-DME-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Drosophila melanogaster)
REACT:R-RNO-8951850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Rattus norvegicus)
REACT:R-MMU-141186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)
RHEA:54204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine
REACT:R-SSC-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Sus scrofa)
REACT:R-CEL-2187388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Caenorhabditis elegans)
REACT:R-CEL-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Caenorhabditis elegans)
REACT:R-HSA-2046363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 kinase mutants are inhibited by PD170734 (Homo sapiens)
REACT:R-HSA-4551738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO2,3 (Homo sapiens)
REACT:R-DME-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Drosophila melanogaster)
REACT:R-MMU-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Mus musculus)
REACT:R-RNO-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Rattus norvegicus)
RHEA:11716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+)
REACT:R-HSA-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Homo sapiens)
GO:0047828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lyxose ketol-isomerase activity
GO:0047828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lyxose isomerase activity
GO:0047828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lyxose aldose-ketose-isomerase activity
RHEA:28354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + FAD + H(+) = (2E)-decenoyl-CoA + FADH2
REACT:R-HSA-9701557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter (Homo sapiens)
REACT:R-CEL-169895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk's SH3 domain engages C3G (Caenorhabditis elegans)
REACT:R-CFA-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Canis familiaris)
REACT:R-DDI-1678742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses Heparan sulfate chain(4) (Dictyostelium discoideum)
REACT:R-HSA-6794338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GKAPs bind PSD-95 members (Homo sapiens)
RHEA:57297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + glycolate + H(+)
REACT:R-BTA-9697747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at TNFR signaling complex (Bos taurus)
REACT:R-RNO-8875659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Rattus norvegicus)
RHEA:54575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in tRNA <=> a pseudouridine in tRNA
REACT:R-SSC-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Sus scrofa)
REACT:R-HSA-209859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decarboxylation of 5-hydroxytryptophan forms serotonin (Homo sapiens)
REACT:R-BTA-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Bos taurus)
RHEA:61811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP <=> AMP + H(+) + L-alanyl-[peptidyl-carrier protein]
GO:0052814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	medium-chain fatty aldehyde dehydrogenase activity
GO:0052814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	medium-chain aliphatic aldehyde dehydrogenase activity
GO:0052814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	medium-chain-aldehyde dehydrogenase activity
GO:0052814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	medium-chain-aldehyde:NAD+ oxidoreductase activity
RHEA:37744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl phosphate + FMNH2 => phosphate + prenyl-FMNH2
RHEA:35580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 => anthocyanin A11 + D-glucose
REACT:R-DDI-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Dictyostelium discoideum)
RHEA:43730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase] => methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:60957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP
REACT:R-SSC-452097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruited STAT5 is phosphorylated (Sus scrofa)
RHEA:39923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine
RHEA:25751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Homo sapiens)
REACT:R-DRE-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Danio rerio)
RHEA:13145	skos:prefLabel	"1,4-beta-mannosyl-N-acetylglucosamine phosphorylase"
RHEA:13145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine
RHEA:13145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,4-beta-mannosyl-N-acetylglucosamine phosphorylase"
REACT:R-RNO-9706350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates CBL (Rattus norvegicus)
RHEA:18667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + [phosphate](n+1) => (2R)-3-phospho-glyceroyl phosphate + [phosphate](n)
RHEA:43356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl (9Z,12Z)-octadecadienoate(out)
REACT:R-DME-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Drosophila melanogaster)
REACT:R-DRE-9700149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds PLCG1 (Danio rerio)
REACT:R-HSA-9011966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive KDM4B gene expression (Homo sapiens)
REACT:R-SSC-2507854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Sus scrofa)
REACT:R-HSA-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)
RHEA:41514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-hydroxy-L-ornithine + NAD(+) => L-ornithine + NADH + O2
GO:0050286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sorbitol-6-phosphate phosphohydrolase activity
GO:0050286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sorbitol-6-phosphate phosphatase activity
GO:0050286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbitol-6-phosphatase activity
GO:0018835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carbon-phosphorus lyases"
GO:0018835	skos:prefLabel	"Carbon-phosphorus lyases"
GO:0018835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon phosphorus lyase activity
REACT:R-BTA-9018863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Bos taurus)
REACT:R-GGA-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Gallus gallus)
RHEA:10823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate <=> D-erythro-isocitrate
REACT:R-HSA-8855747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Homo sapiens)
RHEA:55573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine => 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine
GO:0022877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose PTS transporter activity
GO:0022877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
REACT:R-CEL-5627072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds GOPC:CFTR (Caenorhabditis elegans)
RHEA:20050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
GO:0071734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-pyruvate-carboxylase ligase activity
GO:0071734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-[pyruvate carboxylase] synthetase activity
GO:0071734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-pyruvate carboxylase synthetase activity
GO:0071734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-[pyruvate carboxylase] ligase activity
GO:0071734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-[pyruvate-carboxylase] ligase activity
GO:0071734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin:apo-pyruvate-carboxylase ligase
RHEA:47169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH
RHEA:28182	skos:prefLabel	"trans-2,3-dihydro-3-hydroxyanthranilate isomerase"
RHEA:28182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate
RHEA:28182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-2,3-dihydro-3-hydroxyanthranilate isomerase"
REACT:R-PFA-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Plasmodium falciparum)
GO:0061685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + H(+) + methanol
GO:0061685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthine methylesterase activity
GO:0061685	skos:prefLabel	"methylated diphthine methylhydrolase"
GO:0061685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylated diphthine methylhydrolase"
GO:0061685	skos:altLabel	"diphthine methylesterase"
REACT:R-RNO-209910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is taken up by thyroid epithelial cells (Rattus norvegicus)
REACT:R-DDI-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
GO:0034813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzo(a)pyrene 7,8-dioxygenase activity
REACT:R-SSC-8931648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Sus scrofa)
RHEA:15861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate
RHEA:15861	skos:prefLabel	"ADP-phosphoglycerate phosphatase"
RHEA:15861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-phosphoglycerate phosphatase"
RHEA:68292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + nonanoyl-CoA = CoA + O-nonanoyl-L-seryl-[protein]
RHEA:50273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => resolvin E1
REACT:R-HSA-9036065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ARSB does not hydrolyse DS (Homo sapiens)
RHEA:71838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) <=> estrone 3-sulfate(in)
REACT:R-XTR-500717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GRIK3 homomer (Xenopus tropicalis)
RHEA:72593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate(in) + H(+)(in) => D-glucuronate(out) + H(+)(out)
REACT:R-RNO-8876484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 transfers CHOL to NPC1 (Rattus norvegicus)
RHEA:19663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + H(+) + NADH => D-mannitol 1-phosphate + NAD(+)
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMO5
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMO4
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DMA oxidase activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	flavin-containing monooxygenase activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylaniline oxidase activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMO3
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMO2
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylaniline N-oxidase activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylaniline monooxygenase activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMO-I
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin mixed function oxidase activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylphenyltetrahydropyridine N-monooxygenase activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ziegler's enzyme
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylaniline monooxygenase (N-oxide-forming) activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMO activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMO-II
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMO1
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD-containing monooxygenase activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin monooxygenase activity
GO:0004499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mixed-function amine oxidase activity
REACT:R-RNO-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Rattus norvegicus)
REACT:R-DRE-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)
REACT:R-MMU-2424246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind lecticans (Mus musculus)
REACT:R-HSA-9612671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 gene expression is stimulated by ERBB4s80:ESR1 (Homo sapiens)
GO:0019726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase
GO:0019726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-mevalonate:NADP+ oxidoreductase
GO:0019726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mevaldate reductase (NADPH) activity
RHEA:21630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + androst-4-ene-3,17-dione + H2O + NADP(+) => 17alpha-hydroxyprogesterone + NADPH + O2
RHEA:30196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,9'-di-cis-phytofluene + plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + plastoquinol-9
RHEA:10588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH = 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]
REACT:R-CFA-8944255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VII (Canis familiaris)
REACT:R-XTR-166792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C2 into C2a and C2b (Xenopus tropicalis)
RHEA:31022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 <=> 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O
REACT:R-MMU-2730837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-10Y-NTAL (Mus musculus)
RHEA:26228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-al + H2O + NAD(+) <=> abieta-7,13-dien-18-oate + 2 H(+) + NADH
GO:0102775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity
REACT:R-SCE-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Saccharomyces cerevisiae)
REACT:R-MMU-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Mus musculus)
REACT:R-MMU-74726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of insulin from insulin receptor (Mus musculus)
GO:0038186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholic acid receptor activity
GO:0038186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCA receptor activity
RHEA:59706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellohexaonate + H(+) => D-cellohexaono-1,5-lactone + H2O
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial polymerase transcription factor activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial transcription initiation factor activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial sequence-specific DNA binding transcription factor activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial sequence-specific DNA-binding transcription factor activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial DNA-binding transcription factor activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial RNA polymerase binding promoter specificity activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitochondrial RNA polymerase promoter specificity activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription factor activity, mitochondrial RNA polymerase core promoter proximal region sequence-specific binding
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial transcription factor activity
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription factor activity, mitochondrial proximal promoter sequence-specific binding
GO:0034246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription factor activity, mitochondrial RNA polymerase core promoter sequence-specific DNA binding
REACT:R-XTR-2395872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)
GO:0008921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide-1,6-galactosyltransferase activity
GO:0008921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS-1,6-galactosyltransferase activity
EC:2.7.8.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferases for other substituted phosphate groups"
EC:2.7.8.-	skos:prefLabel	"Transferases for other substituted phosphate groups"
RHEA:54463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate
RHEA:52468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-SSC-5654586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS binds GRB2:SOS1 (Sus scrofa)
GO:1901235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) = (R)-carnitine(out)
GO:1901235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine transmembrane transporter activity
REACT:R-HSA-9619756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2 binds ABCA1 (Homo sapiens)
REACT:R-SSC-9708866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-F2R binds vorapaxar (Sus scrofa)
REACT:R-RNO-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Rattus norvegicus)
RHEA:24911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L,L-cystathionine => 2-aminobut-2-enoate + L-cysteine
REACT:R-GGA-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Gallus gallus)
RHEA:35248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate
REACT:R-RNO-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Rattus norvegicus)
RHEA:71966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) <=> (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)
REACT:R-MMU-2545203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cleaved cohesin (Mus musculus)
RHEA:40331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-MMU-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Mus musculus)
GO:0015159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polysaccharide transmembrane transporter activity
REACT:R-HSA-158468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates PARA to PARA-SO4 (Homo sapiens)
REACT:R-XTR-1614605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is dioxygenated (Xenopus tropicalis)
REACT:R-SSC-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Sus scrofa)
REACT:R-DDI-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Dictyostelium discoideum)
RHEA:67765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
GO:0034565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity
REACT:R-DDI-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)
RHEA:48244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1b + H(+)
REACT:R-BTA-193072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
RHEA:36655	skos:prefLabel	"demethyldecarbamoylnovobiocin O-methyltransferase"
RHEA:36655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine = descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine
RHEA:36655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethyldecarbamoylnovobiocin O-methyltransferase"
REACT:R-HSA-5336417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DT A:B binds HBEGF and CD9 on the target cell surface (Homo sapiens)
REACT:R-MTU-964886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPSP from shikimate 3-phosphate (Mycobacterium tuberculosis)
REACT:R-HSA-77587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)
RHEA:63604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Pyr1]apelin-13 + H2O = [Pyr1]apelin-12 + L-phenylalanine
REACT:R-SSC-5618328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAT acetylates microtubules (Sus scrofa)
RHEA:55021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O => 5,6-diaminouracil + D-ribose 5-phosphate
REACT:R-GGA-982768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GH:GHR:JAK2 complex undergoes a conformational change (Gallus gallus)
RHEA:17149	skos:altLabel	"xenobiotic monooxygenase"
RHEA:17149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"unspecific monooxygenase"
RHEA:17149	skos:altLabel	"aryl-4-monooxygenase"
RHEA:17149	skos:altLabel	"aryl hydrocarbon hydroxylase"
RHEA:17149	skos:altLabel	"microsomal monooxygenase"
RHEA:17149	skos:altLabel	"flavoprotein-linked monooxygenase"
RHEA:17149	skos:altLabel	"microsomal P450"
RHEA:17149	skos:prefLabel	"unspecific monooxygenase"
RHEA:17149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:17149	skos:altLabel	"cytochrome P450"
RHEA:66479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenate + UDP-alpha-D-glucose <=> gypsogenate 28-beta-D-glucoside + UDP
REACT:R-CFA-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)
REACT:R-SPO-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
REACT:R-DRE-9618378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 binds the Nup107-Nup160 complex (Danio rerio)
RHEA:66743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate
RHEA:36253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + AMP + diphosphate => (E)-ferulate + ATP + CoA
RHEA:53339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20) in tRNA
REACT:R-XTR-9033509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5L (Xenopus tropicalis)
REACT:R-SSC-5662620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds cadmium (Sus scrofa)
RHEA:50946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) + NADH => 3-phenylpropanoate + NAD(+)
REACT:R-MMU-5218838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXN binds p-6Y,S732-PTK2 (Mus musculus)
RHEA:54744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-114671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vWF binds to collagen (Canis familiaris)
RHEA:42536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA pseudouridine(65) synthase"
RHEA:42536	skos:prefLabel	"tRNA pseudouridine(65) synthase"
RHEA:42536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(65) in tRNA = pseudouridine(65) in tRNA
REACT:R-BTA-5626316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Bos taurus)
RHEA:35366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH <=> isopentadecanoyl-CoA + NADP(+)
RHEA:58939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + 2 diphosphate + NAD(+)
RHEA:70387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-3-oxosphinganine
REACT:R-BTA-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Bos taurus)
REACT:R-SSC-9707353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 binds Aromatase inhibitors (Sus scrofa)
EC:3.1.6.12	skos:altLabel	"chondroitinase"
EC:3.1.6.12	skos:altLabel	"arylsulfatase B"
EC:3.1.6.12	skos:prefLabel	"N-acetylgalactosamine-4-sulfatase"
EC:3.1.6.12	skos:altLabel	"chondroitinsulfatase"
EC:3.1.6.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylgalactosamine-4-sulfatase"
REACT:R-CFA-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
REACT:R-CFA-1369017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in muscle cells (Canis familiaris)
REACT:R-CEL-8877813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND5A,B exchange GTP for GDP on RAB39 (Caenorhabditis elegans)
RHEA:56084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-O-phosphocholine-L-serine + H2O = [Rab1 protein]-L-serine + H(+) + phosphocholine
RHEA:13623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose => 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose
REACT:R-RNO-8854908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates RET:GDNF:GFRA dimer (Rattus norvegicus)
RHEA:20215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein] => L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein]
RHEA:37589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-2-oxohexanoate + L-glutamate => 2-oxoglutarate + D-lysine
REACT:R-BTA-5635864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH ubiquitinates GLI1 (Bos taurus)
RHEA:22960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoflavone 3'-hydroxylase"
RHEA:22960	skos:prefLabel	"isoflavone 3'-hydroxylase"
RHEA:22960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formononetin + O2 + reduced [NADPH--hemoprotein reductase] = calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:22960	skos:altLabel	"CYP81E9"
RHEA:41261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-3-(indol-3-yl)acrylate + NH4(+) => L-tryptophan
RHEA:39701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z)-eicosadienoyl-CoA + H2O => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA
RHEA:67299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 <=> (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2
REACT:R-GGA-2168883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin:Hemoglobin binds CD163 (Gallus gallus)
REACT:R-RNO-9667965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds PP2A (Rattus norvegicus)
REACT:R-MMU-6785181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 bind LIPC dimer (Mus musculus)
RHEA:20498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-arylethylamine + acetyl-CoA => CoA + H(+) + N-acetyl-2-arylethylamine
RHEA:45894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+) => an N-acylsphing-4-enine + CDP-ethanolamine
RHEA:14524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + NADP(+) <=> (2E)-geranial + H(+) + NADPH
RHEA:55875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) <=> 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH
REACT:R-DRE-429613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-CEL-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Caenorhabditis elegans)
REACT:R-RNO-216756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)
RHEA:41715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
RHEA:72135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine(out) = putrescine(in)
RHEA:11225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 2 D-alanine => ADP + D-alanyl-D-alanine + H(+) + phosphate
RHEA:72555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + propanoate(in) = estrone 3-sulfate(in) + propanoate(out)
REACT:R-HSA-9650165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers bind H+ (Homo sapiens)
RHEA:58721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nicotine + NADPH + O2 => H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide
REACT:R-SSC-163664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binds to gamma subunit of AMP kinase heterotrimer (Sus scrofa)
RHEA:59068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethyldeoxyspectinabilin + S-adenosyl-L-methionine = deoxyspectinabilin + S-adenosyl-L-homocysteine
RHEA:36440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate
REACT:R-DDI-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Dictyostelium discoideum)
RHEA:30712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-linalool => beta-myrcene + H2O
RHEA:43449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:38658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-tuliposide B <=> D-glucose + tulipalin B
RHEA:37253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteamine + phosphate => cysteamine S-phosphate + H2O
REACT:R-CEL-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Caenorhabditis elegans)
REACT:R-MMU-6800870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the FP subcomplex (Mus musculus)
REACT:R-SSC-2064417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-1 (TJP1) (Sus scrofa)
GO:0103055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A15 + O2 = CO2 + gibberellin A24 + H2O + succinate
GO:0103055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity
REACT:R-HSA-175174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Ku heterodimer with viral DNA ends (Homo sapiens)
REACT:R-GGA-5690196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates RNF128 (Gallus gallus)
RHEA:65318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin E + CO2 + H2O + succinate => 2-oxoglutarate + chrodrimanin H + O2
RHEA:46301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = (9R)-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-MMU-9029680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-7 translocates to the nucleus (Mus musculus)
RHEA:42380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O = 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)
REACT:R-MMU-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Mus musculus)
RHEA:67505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:63515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2'-diol + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + H2O + NAD(+)
RHEA:54057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-hedycaryol + diphosphate
REACT:R-HSA-9701534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, S727 STAT3 dimer binds HIF1A gene (Homo sapiens)
RHEA:30616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 2 A => 2 AH2 + all-trans-zeta-carotene
RHEA:68403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-gurjunene
REACT:R-HSA-5683967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)
REACT:R-RNO-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)
GO:0036081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular ammonia-gated ion channel activity
GO:0036081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ionotropic ammonia receptor activity
REACT:R-GGA-201475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with R-Smad1/5/8 for type I receptor (Gallus gallus)
REACT:R-BTA-6784399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Bos taurus)
REACT:R-PFA-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Plasmodium falciparum)
RHEA:51937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(glutathione-S-yl)-hydroquinone + glutathione => glutathione disulfide + hydroquinone
REACT:R-SSC-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Sus scrofa)
GO:1990188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	euchromatin binding
REACT:R-HSA-8949335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter (Homo sapiens)
REACT:R-HSA-1972385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-Ribosylation of HNP-1 (Homo sapiens)
REACT:R-DRE-174706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Danio rerio)
REACT:R-MMU-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Mus musculus)
REACT:R-DRE-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Danio rerio)
REACT:R-DDI-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Dictyostelium discoideum)
REACT:R-SSC-201717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK2-mediated phosphorylation of DVL (Sus scrofa)
REACT:R-HSA-5649681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL2 cleaves 5-OHU from damaged DNA (Homo sapiens)
REACT:R-MMU-2294590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds phosphorylated condensin II complex (Mus musculus)
REACT:R-SSC-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Sus scrofa)
REACT:R-BTA-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Bos taurus)
RHEA:69039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-androstane-3,17-dione + H(+) + NADPH <=> 3beta-hydroxy-5beta-androstane-17-one + NADP(+)
REACT:R-DRE-166245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Danio rerio)
REACT:R-DRE-77323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Danio rerio)
REACT:R-HSA-2730871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RasGRP interacts with DAG and Ca2+ (Homo sapiens)
RHEA:53090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine
REACT:R-DME-3928595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ARP2/3 and G-actin (Drosophila melanogaster)
RHEA:49984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + jasmonate + NADPH + O2 = (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)
RHEA:49984	skos:prefLabel	"jasmomic acid 12-hydroxylase"
RHEA:49984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"jasmomic acid 12-hydroxylase"
RHEA:50118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-eicosanoyl-taurine => eicosanoyl-CoA + taurine
GO:0005507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copper ion binding
GO:0005507	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	copper/cadmium binding
GO:0005507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copper binding
RHEA:33674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O <=> 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2
REACT:R-XTR-1067688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)
RHEA:19610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine
REACT:R-SSC-8852552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1R autophosphorylates (Sus scrofa)
RHEA:35756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-alpha-D-glucose => H(+) + NADH + UDP-3-oxo-alpha-D-glucose
REACT:R-BTA-8982617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB:O2 dissociates (Bos taurus)
RHEA:25463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + sibirene
GO:0055042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-valerolactone hydrolase activity
RHEA:15258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threonine => acetaldehyde + glycine
RHEA:63969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate + H(+) => atromentin + 2 H2O
REACT:R-SSC-5661122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2R3-histone H3 (Sus scrofa)
REACT:R-XTR-1678998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosomal TLRs pass through the Golgi (Xenopus tropicalis)
RHEA:59669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellohexaose + O2 => D-cellohexaono-1,5-lactone + H2O2
REACT:R-DME-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Drosophila melanogaster)
REACT:R-MMU-2509793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses dIDP to dIMP (Mus musculus)
REACT:R-BTA-2161951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)
RHEA:55716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)
REACT:R-RNO-2395412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SYK (Rattus norvegicus)
RHEA:63291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate
REACT:R-SSC-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Sus scrofa)
REACT:R-GGA-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Gallus gallus)
REACT:R-HSA-8961699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXO5 gene expression is stimulated by E2F1 (Homo sapiens)
RHEA:55037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N,N-dimethylornithine lipid + S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-5654734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Bos taurus)
REACT:R-MMU-8849353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Mus musculus)
REACT:R-RNO-4754181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me2K5-histone H3 (Rattus norvegicus)
REACT:R-HSA-5688276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT4 transfers ADPRib to GLUD (Homo sapiens)
RHEA:19877	skos:altLabel	"phosphatidylinositol kinase"
RHEA:19877	skos:altLabel	"PI4K-alpha"
RHEA:19877	skos:prefLabel	"1-phosphatidylinositol 4-kinase"
RHEA:19877	skos:altLabel	"phosphatidylinositol 4-kinase"
RHEA:19877	skos:altLabel	"phosphatidylinositol kinase (phosphorylating)"
RHEA:19877	skos:altLabel	"type II phosphatidylinositol kinase"
RHEA:19877	skos:altLabel	"PtdIns-4-kinase"
RHEA:19877	skos:altLabel	"PI4-kinase"
RHEA:19877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
RHEA:19877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-phosphatidylinositol 4-kinase"
RHEA:19877	skos:altLabel	"PI kinase"
RHEA:72897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine => 2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine
RHEA:45560	skos:altLabel	"BCAA racemase"
RHEA:45560	skos:prefLabel	"isoleucine 2-epimerase"
RHEA:45560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoleucine 2-epimerase"
RHEA:45560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine = D-allo-isoleucine
RHEA:11839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
REACT:R-DRE-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Danio rerio)
RHEA:16872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
REACT:R-XTR-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Xenopus tropicalis)
RHEA:44696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine
REACT:R-GGA-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Gallus gallus)
REACT:R-DDI-9024997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Dictyostelium discoideum)
REACT:R-DRE-419389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA-binding receptors bind LPA (Danio rerio)
REACT:R-HSA-2327746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 aggregation (Homo sapiens)
REACT:R-CFA-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Canis familiaris)
REACT:R-XTR-1236943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigen peptide onto MHC class I molecule (Xenopus tropicalis)
RHEA:45687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-dodecanoyl-sphing-4-enine-1-phosphate(in) <=> N-dodecanoyl-sphing-4-enine-1-phosphate(out)
RHEA:18488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-acetyl-D-glucose + H2O <=> acetate + D-glucose + H(+)
REACT:R-DRE-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Danio rerio)
REACT:R-BTA-2855125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-1 binds to molecular patterns on the target cell surface (Bos taurus)
REACT:R-BTA-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
RHEA:29215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + menaquinol-8 = menaquinone-8 + succinate
REACT:R-CFA-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Canis familiaris)
REACT:R-GGA-9018499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and EP300 are recruited to TFF3 promoter (Gallus gallus)
RHEA:40269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanedioyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanedioyl-CoA + NAD(+)
REACT:R-HSA-450466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1:mRNA complex is destroyed (Homo sapiens)
RHEA:53442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-5423656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFXBO hydrolyses non-enzymatically to AFBDHD (Homo sapiens)
REACT:R-CFA-6814153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADO oxidises 2AET to HTAU (Canis familiaris)
REACT:R-DME-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)
REACT:R-RNO-111746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Rattus norvegicus)
RHEA:34349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranial + H(+) + NADH => (2E)-geraniol + NAD(+)
RHEA:71592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + malonate(in) => 2-oxoglutarate(in) + malonate(out)
RHEA:33732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin
REACT:R-GGA-8875523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS3 (Gallus gallus)
RHEA:11131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA
RHEA:70237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol
RHEA:37519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
GO:0047566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity
GO:0047566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketovalidoxylamine A C-N-lyase activity
GO:0047566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketovalidoxylamine C-N-lyase activity
GO:0047566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]
GO:0047566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity
REACT:R-CFA-156526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)
REACT:R-GGA-6807008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates MET (Gallus gallus)
REACT:R-RNO-209973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is diiodinated (Rattus norvegicus)
RHEA:60372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose(out) = D-fructose(in)
RHEA:31446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-sedoheptulose 7-phosphate <=> ADP + D-sedoheptulose 1,7-bisphosphate + H(+)
REACT:R-HSA-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Homo sapiens)
RHEA:45118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ipsdienone + NADPH => (4R)-ipsdienol + NADP(+)
REACT:R-RNO-2129353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin associates with microfibrils (Rattus norvegicus)
RHEA:32680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => (2E)-geraniol + diphosphate
RHEA:15151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + pyridoxal 5'-phosphate => O2 + pyridoxine 5'-phosphate
RHEA:51782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadlupulone + diphosphate => 4-prenylphlormethylbutanophenone + dimethylallyl diphosphate
RHEA:51767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + phlorisovalerophenone <=> 4-prenylphlorisovalerophenone + diphosphate
RHEA:58915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + iron(III) dicitrate(out) <=> ADP + H(+) + iron(III) dicitrate(in) + phosphate
REACT:R-CEL-4615905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO1 (Caenorhabditis elegans)
RHEA:36867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-RNO-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Rattus norvegicus)
GO:0033403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTA codon-amino acid adaptor activity
GO:0033403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine tRNA
GO:0033403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UUA codon-amino acid adaptor activity
RHEA:48599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoylglycerol + H2O <=> decanoate + decanoylglycerol + H(+)
RHEA:72411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inulobiose = alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O
REACT:R-HSA-5685994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)
REACT:R-GGA-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Gallus gallus)
REACT:R-CFA-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Canis familiaris)
RHEA:64251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + glycine <=> CoA + H(+) + N-decanoylglycine
RHEA:31695	skos:altLabel	"10R-DOX"
RHEA:31695	skos:altLabel	"10R-dioxygenase"
RHEA:31695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
RHEA:31695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linoleate 10R-lipoxygenase"
RHEA:31695	skos:altLabel	"(10R)-dioxygenase"
RHEA:31695	skos:prefLabel	"linoleate 10R-lipoxygenase"
RHEA:51680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + CTP = (2E,6E)-farnesyl phosphate + CDP + H(+)
REACT:R-MMU-9679029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds HCQ (Mus musculus)
REACT:R-BTA-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Bos taurus)
REACT:R-SSC-416929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PGF2a (Sus scrofa)
REACT:R-RNO-5696534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 deubiquitinates TAK1:TAB1 (Rattus norvegicus)
REACT:R-RNO-8851797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 in ADRB2:GRK complex is phosphorylated (Rattus norvegicus)
RHEA:21414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 1-phosphate
REACT:R-DRE-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Danio rerio)
REACT:R-GGA-140806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINC1 binds SERPINC1 activators (Gallus gallus)
REACT:R-SSC-5423038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Sus scrofa)
REACT:R-HSA-9610388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCMV translocates from the endosome lumen to the extracellular region (Homo sapiens)
RHEA:16137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + NADP(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADPH
REACT:R-SSC-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Sus scrofa)
RHEA:33391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C20 sphinganine 1-phosphate + H2O = C20 sphinganine + phosphate
RHEA:41281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoate + sphing-4-enine => H2O + N-octadecanoylsphing-4-enine
REACT:R-GGA-1067676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST-2 (Gallus gallus)
REACT:R-XTR-5649800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)
REACT:R-RNO-1602377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Rattus norvegicus)
REACT:R-HSA-4086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO2,3 (Homo sapiens)
REACT:R-RNO-1470010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs (Rattus norvegicus)
GO:0097322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7SK snRNA binding
GO:0097322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7SK small nuclear RNA binding
RHEA:22461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + NADP(+) => a 2,3-dehydroacyl-CoA + H(+) + NADPH
REACT:R-HSA-9757698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDN,PREDL diffuse into hepatic cells (Homo sapiens)
RHEA:70404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 3-oxosphinganine => CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine
REACT:R-XTR-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Xenopus tropicalis)
RHEA:36691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-octadecanoylsphing-4-enine
REACT:R-SCE-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Saccharomyces cerevisiae)
RHEA:55149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH
REACT:R-HSA-1169421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)
REACT:R-BTA-5691411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Bos taurus)
RHEA:29685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + alpha-maltopentaose => alpha-maltohexaose + phosphate
RHEA:39560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O
REACT:R-MMU-9690449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 bind S1P (Mus musculus)
RHEA:23961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O2 + hexadecanoate => CO2 + 3 H2O + pentadecanal
REACT:R-BTA-205231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of KIT upon SCF binding (Bos taurus)
REACT:R-BTA-5693148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDK phosphorylates BCKDH (Bos taurus)
REACT:R-GGA-200421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of cytosolic AMPK by phosphorylation (Gallus gallus)
REACT:R-RNO-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Rattus norvegicus)
REACT:R-MMU-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Mus musculus)
REACT:R-XTR-2161293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin forms aggregate globules (Xenopus tropicalis)
REACT:R-BTA-8983872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Bos taurus)
RHEA:42835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H(+) + pyruvate <=> (S)-3-acetyloctanal + CO2
RHEA:39761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DDI-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Dictyostelium discoideum)
REACT:R-HSA-2471842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XXV ectomain shedding (Homo sapiens)
REACT:R-CEL-990489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-13 is a dimer (Caenorhabditis elegans)
REACT:R-MMU-9023619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Mus musculus)
RHEA:28934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate
RHEA:41965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + O2 => (2E)-butenoyl-CoA + H2O2
REACT:R-BTA-8869607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NAR to yield NAMN (Bos taurus)
RHEA:16206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate
REACT:R-HSA-6787447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA (Homo sapiens)
GO:0005294	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neutral L-amino acid porter activity
GO:0005294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral L-amino acid secondary active transmembrane transporter activity
RHEA:65110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene A + holo-[peptidyl-carrier protein] => aculene C + L-prolyl-[peptidyl-carrier protein]
RHEA:19040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an epoxide + H2O <=> an ethanediol
REACT:R-DRE-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Danio rerio)
GO:0047001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity
GO:0047001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygluconate dehydrogenase activity
GO:0047001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase"
GO:0047001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity
GO:0047001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH
GO:0047001	skos:prefLabel	"2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase"
GO:0047001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity
GO:0047001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygluconate 5-dehydrogenase activity
GO:0047001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity
GO:0047001	skos:altLabel	"2-keto-3-deoxy-D-gluconate dehydrogenase"
GO:0047001	skos:altLabel	"2-keto-3-deoxygluconate dehydrogenase"
REACT:R-HSA-6785933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT8 transfers Gal from UDP-Gal to CERA (Homo sapiens)
RHEA:54566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+) => a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O
REACT:R-DRE-5693751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH2 hydrolyses AEA to AA and ETA (Danio rerio)
RHEA:67555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + cholate <=> adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)
REACT:R-DRE-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)
REACT:R-GGA-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Gallus gallus)
GO:0047899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent formate dehydrogenase activity
GO:0047899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate:NADP+ oxidoreductase activity
GO:0047899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate dehydrogenase (NADP+) activity
REACT:R-HSA-110235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine (Homo sapiens)
RHEA:62270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + H(+) + NADPH => (R)-2-hydroxy-3-methylbutyrate + NADP(+)
GO:0008495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme A:farnesyltransferase activity
GO:0008495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme O synthase activity
GO:0008495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protohaem IX farnesyltransferase activity
GO:0008495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoheme IX farnesyltransferase activity
GO:0008495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	haem O synthase activity
REACT:R-MMU-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Mus musculus)
RHEA:18318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid => a D-alpha-amino acid
RHEA:52235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin a
REACT:R-MMU-171059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Mus musculus)
REACT:R-RNO-203680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:NOSIP translocation from caveolae to intracellular compartments (Rattus norvegicus)
RHEA:37844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-445813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
REACT:R-RNO-354073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
RHEA:45359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(11Z-eicosenoyl)-sphing-4-enine <=> (11Z)-eicosenoate + sphing-4-enine
REACT:R-DRE-2396399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillins bind BMPs (Danio rerio)
REACT:R-MMU-9005980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 binds IL21R:JAK1 (Mus musculus)
RHEA:69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-glutamyl-[tubulin] <=> ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate
REACT:R-CFA-5654592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
REACT:R-BTA-9029561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to the ABCA1 promoter (Bos taurus)
REACT:R-DME-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)
GO:0018600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene dehydrogenase activity
RHEA:62766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2
RHEA:22205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)
RHEA:65234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydodecanoate + CoA + H(+) => 3-hydroxydodecanoyl-CoA + H2O
RHEA:17604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribulose <=> ADP + D-ribulose 5-phosphate + H(+)
REACT:R-SSC-200424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Sus scrofa)
RHEA:16227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(6-aminohexanoyl)-6-aminohexanoate => 1,8-diazacyclotetradecane-2,9-dione + H2O
REACT:R-MMU-9026006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Mus musculus)
REACT:R-CFA-173709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C7 binds C5b:C6 (Canis familiaris)
REACT:R-HSA-4839634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
REACT:R-XTR-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Xenopus tropicalis)
RHEA:41438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z-octadecenoate) + CoA => (9Z)-octadecenoyl-CoA + cholesterol
RHEA:34597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-15-methylhexadecasphinganine + CO2 + CoA => H(+) + isopentadecanoyl-CoA + L-serine
REACT:R-CFA-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)
REACT:R-SSC-5625796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM4C binds KLK2 and KLK3 promoters (Sus scrofa)
REACT:R-DME-9634846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNTL (BMAL1) (Drosophila melanogaster)
REACT:R-RNO-83790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Rattus norvegicus)
RHEA:68820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate
RHEA:71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-methionine(out) + 2 Na(+)(out) = chloride(in) + L-methionine(in) + 2 Na(+)(in)
RHEA:64892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[ACP] + tetradecanoyl-AMP = AMP + H(+) + tetradecanoyl-[ACP]
REACT:R-DRE-6806613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin tetramers bind to form unit length filaments (Danio rerio)
REACT:R-BTA-9015111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors binds Xa (Bos taurus)
REACT:R-DME-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Drosophila melanogaster)
RHEA:13948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-mandelate <=> (R)-mandelate
REACT:R-SSC-1234173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)
REACT:R-HSA-5621363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Homo sapiens)
RHEA:61320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide
RHEA:32574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylgeranyl diphosphate + H2O <=> 2-methylisoborneol + diphosphate
REACT:R-CFA-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Canis familiaris)
RHEA:61813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose => dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP
REACT:R-PFA-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Plasmodium falciparum)
REACT:R-BTA-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Bos taurus)
RHEA:54790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide
REACT:R-CEL-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Caenorhabditis elegans)
RHEA:33978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIMBOA beta-D-glucoside + H2O <=> D-glucose + DIMBOA
RHEA:10559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + L-arginine <=> H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate
RHEA:57250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP
RHEA:34953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate(in) => 3-hydroxypropanoate(out)
RHEA:47917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-hexanoyl-(4R)-hydroxysphinganine => ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate
RHEA:42322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O
REACT:R-RNO-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Rattus norvegicus)
REACT:R-CFA-8848247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD4,5 bind MCFA-CoA and LCFA-CoA (Canis familiaris)
REACT:R-MMU-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)
REACT:R-HSA-2471641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective OPN1MW causes COD5 (Homo sapiens)
RHEA:46710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + salicyl-[non-ribosomal peptide synthase] => 2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase]
REACT:R-HSA-6803523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)
RHEA:55781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate => all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP
RHEA:44062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA
REACT:R-BTA-158164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Bos taurus)
REACT:R-DME-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Drosophila melanogaster)
REACT:R-MMU-9014074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin4 (Mus musculus)
REACT:R-MMU-8952716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 binds Ragulator:Rag dimers (Mus musculus)
RHEA:53611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + O2 <=> (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)
REACT:R-MMU-965067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THTPA:Mg2+ hydrolyzes ThTP to TDP (Mus musculus)
GO:0052795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-alpha-(2->6)-sialidase activity
GO:0052795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-alpha-(2,6)-sialidase activity
GO:0052795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-alpha-2,6-sialidase activity
REACT:R-XTR-5617179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates TNNI3 (Xenopus tropicalis)
RHEA:12760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrozeatin + NADP(+) <=> H(+) + NADPH + zeatin
RHEA:32109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pterostilbene + S-adenosyl-L-homocysteine => 3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine
RHEA:44697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine
REACT:R-HSA-9026000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA (Homo sapiens)
RHEA:52493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-9676160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds NOD2 (Bos taurus)
RHEA:29276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(in) + Na(+)(in) => L-isoleucine(out) + Na(+)(out)
REACT:R-RNO-2672334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNN channels transport extracellular Na+ to cytosol (Rattus norvegicus)
REACT:R-BTA-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Bos taurus)
GO:0001003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase III type 2 promoter DNA binding
GO:0001003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III type 2 promoter sequence-specific DNA binding
REACT:R-BTA-2168079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL (GWL) phosphorylates ARPP19 (Bos taurus)
REACT:R-DME-209357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-HH is palmitoylated by RASP (Drosophila melanogaster)
REACT:R-HSA-166286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiple IRAK1 autophosphorylation steps (Homo sapiens)
REACT:R-CFA-2130393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex along Golgi to TGN (Canis familiaris)
REACT:R-GGA-8869694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds CD14 (Gallus gallus)
REACT:R-RNO-4085372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO2,3 (Rattus norvegicus)
RHEA:62691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 norrubrofusarin + O2 <=> 2 H2O + 2 ustilaginoidin A
RHEA:43969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate
REACT:R-HSA-8962039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TK1 gene expression is stimulated by E2F1 (Homo sapiens)
RHEA:62026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesterol + D-glucose => campesteryl 3-beta-D-glucoside + H2O
RHEA:45881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA
RHEA:30984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]
RHEA:46966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-MMU-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Mus musculus)
REACT:R-DME-350475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLW:MBS complex dephosphorylates SQH (Drosophila melanogaster)
REACT:R-SSC-449058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family are secreted (Sus scrofa)
RHEA:11437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 => 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O
RHEA:53929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tertiary amine + S-adenosyl-L-methionine => a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Danio rerio)
REACT:R-GGA-2294590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds phosphorylated condensin II complex (Gallus gallus)
RHEA:51788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-5'-AMP + CoA = 2-hydroxybenzoyl-CoA + AMP + H(+)
RHEA:41802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxobutanoyl-[ACP] + CO2 + holo-[ACP] => acetyl-[ACP] + H(+) + malonyl-[ACP]
RHEA:50133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl hexadecanoate + H2O => ethanol + H(+) + hexadecanoate
REACT:R-SSC-450463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Sus scrofa)
REACT:R-SSC-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Sus scrofa)
RHEA:41340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoate + O2 = 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate
REACT:R-XTR-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Xenopus tropicalis)
RHEA:19131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dTMP + H(+) => ATP + thymidine
REACT:R-HSA-9619367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKKs phosphorylate CAMK1 (Homo sapiens)
RHEA:52490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase]
RHEA:57159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[protein] + O2 <=> 4-hydroxy-L-lysyl-[protein] + CO2 + succinate
RHEA:62079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose 6-phosphate + NAD(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADH
RHEA:15116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol
REACT:R-HSA-937044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
RHEA:42382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+) => 2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O
REACT:R-DME-9708430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 (CRM1) binds to BACH1:Hemes (Drosophila melanogaster)
REACT:R-DME-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Drosophila melanogaster)
GO:0102272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homophytochelatin synthase activity (polymer-forming)
REACT:R-RNO-5692781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Rattus norvegicus)
RHEA:46685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-24-oyl-CoA + A => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2
REACT:R-HSA-8987096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)
REACT:R-DME-170070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Drosophila melanogaster)
RHEA:21653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chlorobenzoate + H(+) + NADH + O2 => catechol + chloride + CO2 + NAD(+)
REACT:R-SCE-2730868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK7 by MEKK1 (Saccharomyces cerevisiae)
REACT:R-CFA-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
RHEA:30769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + H(+) => D-glucurono-3,6-lactone + H2O
REACT:R-HSA-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Homo sapiens)
RHEA:46184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + isovalerate = 3-methylbutanoyl-CoA + AMP + diphosphate
REACT:R-DME-1449687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticosteroids bind to CBG in blood (Drosophila melanogaster)
GO:0005402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate:cation symporter activity
GO:0005402	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sugar:cation symporter activity
GO:0005402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation/sugar symporter activity
GO:0005402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation:sugar symporter activity
RHEA:37742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA
RHEA:61066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine
RHEA:34696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => Delta(6)-protoilludene + diphosphate
RHEA:21404	skos:prefLabel	"chlorite O2-lyase"
RHEA:21404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + O2 = chlorite
RHEA:21404	skos:altLabel	"chlorite dismutase"
RHEA:21404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorite O2-lyase"
RHEA:60049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)
RHEA:55933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O => AMP + H(+) + L-threonyl-[protein]
EC:3.4.24.12	skos:altLabel	"sea-urchin-hatching proteinase"
EC:3.4.24.12	skos:prefLabel	"envelysin"
EC:3.4.24.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"envelysin"
EC:3.4.24.12	skos:altLabel	"hatching enzyme"
REACT:R-XTR-2267372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Xenopus tropicalis)
GO:0098769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMP family protein binding
RHEA:69763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty aldehyde + H2O + NAD(+) = a medium chain fatty acid + 2 H(+) + NADH
RHEA:66528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]
RHEA:52869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-DRE-4720432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Danio rerio)
REACT:R-BTA-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Bos taurus)
RHEA:72835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cUAMP + H2O = H(+) + U[3'-5']pAp[3']
REACT:R-DRE-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Danio rerio)
REACT:R-MMU-5244692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Mus musculus)
RHEA:52637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 => a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate
RHEA:35576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Schizosaccharomyces pombe)
REACT:R-DME-450333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Drosophila melanogaster)
RHEA:61387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate
REACT:R-SSC-1678742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses Heparan sulfate chain(4) (Sus scrofa)
REACT:R-BTA-1433374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processing of SCF isoform 1 (Bos taurus)
RHEA:30898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + propane-1,3-diamine <=> 3-aminopropanal + H2O2 + NH4(+)
RHEA:72529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine
RHEA:38605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-phospho-cyclic ADP-ribose + nicotinamide => NADP(+)
REACT:R-BTA-203613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylation of eNOS (Bos taurus)
REACT:R-BTA-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)
RHEA:19108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + H2O + NAD(+) <=> 4-aminobutanoate + 2 H(+) + NADH
EC:4.2.1.35	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-2-methylmalate dehydratase"
EC:4.2.1.35	skos:prefLabel	"(R)-2-methylmalate dehydratase"
EC:4.2.1.35	skos:altLabel	"citraconate hydratase"
REACT:R-SPO-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Schizosaccharomyces pombe)
RHEA:30546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine + ATP + CoA <=> (S)-carnitinyl-CoA + ADP + phosphate
REACT:R-MMU-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Mus musculus)
RHEA:17404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate + H2O
REACT:R-MTU-964914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHQ from DAHP dephosphorylation (Mycobacterium tuberculosis)
REACT:R-SSC-5606996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds activated protein C (Sus scrofa)
REACT:R-HSA-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Homo sapiens)
REACT:R-RNO-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Rattus norvegicus)
REACT:R-MMU-9610152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Mus musculus)
REACT:R-GGA-4615872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO1 (Gallus gallus)
RHEA:55112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)
REACT:R-SSC-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Sus scrofa)
REACT:R-CFA-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Canis familiaris)
REACT:R-CEL-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Caenorhabditis elegans)
RHEA:59969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-threonyl-[protein]
RHEA:33036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:38881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(out) => a fatty acid(in)
RHEA:54442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-H-anthocyanidin with a 3-hydroxy group + H2O => a (4S)-2,3-dehydroflavan-3,4-diol + H(+)
GO:1905057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
GO:1905057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905057	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
REACT:R-SSC-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Sus scrofa)
RHEA:68545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate
RHEA:15963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + taxiphyllin + UDP => 4-hydroxymandelonitrile + UDP-alpha-D-glucose
REACT:R-BTA-373717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacts with DIP13alpha (Bos taurus)
RHEA:14419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-acetyl-L-lysine + phosphate => acetyl phosphate + L-lysine
REACT:R-DME-210694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2 (Drosophila melanogaster)
REACT:R-DDI-9026005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Dictyostelium discoideum)
REACT:R-SSC-158832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT2 (Sus scrofa)
REACT:R-CFA-112436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin complex (Canis familiaris)
REACT:R-HSA-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Homo sapiens)
REACT:R-SSC-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Sus scrofa)
RHEA:63099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ilicicolin A epoxide <=> ilicicolin C
REACT:R-BTA-202248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma1 (Bos taurus)
REACT:R-MMU-5624132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Mus musculus)
RHEA:40798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
RHEA:10393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamyl alcohol + NADP(+) => (E)-cinnamaldehyde + H(+) + NADPH
EC:6.3.1.19	skos:prefLabel	"prokaryotic ubiquitin-like protein ligase"
EC:6.3.1.19	skos:altLabel	"Pup-conjugating enzyme"
EC:6.3.1.19	skos:altLabel	"proteasome accessory factor A"
EC:6.3.1.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prokaryotic ubiquitin-like protein ligase"
EC:6.3.1.19	skos:altLabel	"Pup--protein ligase"
EC:6.3.1.19	skos:altLabel	"Pup ligase"
RHEA:19561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADPH + O2 = H2O + NADP(+) + testololactone
GO:0046573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactonohydrolase activity
RHEA:19954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-alanine => an L-alpha-amino acid + pyruvate
GO:0034564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity
REACT:R-CEL-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Caenorhabditis elegans)
REACT:R-SPO-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Schizosaccharomyces pombe)
REACT:R-SSC-8944263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type II (Sus scrofa)
REACT:R-RNO-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Rattus norvegicus)
REACT:R-DME-187545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)
RHEA:11547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine
RHEA:32959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine + NAD(+) = (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)
RHEA:24619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + NADP(+) <=> estrone + H(+) + NADPH
RHEA:19309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate
RHEA:19309	skos:prefLabel	"mannosyl-3-phosphoglycerate phosphatase"
RHEA:19309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosyl-3-phosphoglycerate phosphatase"
REACT:R-MMU-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Mus musculus)
REACT:R-BTA-173705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b binds C6 (Bos taurus)
GO:0009385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylmannosamine-6-P epimerase activity
GO:0009385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylmannosamine-6-phosphate 2-epimerase activity
REACT:R-BTA-109338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Bos taurus)
RHEA:16213	skos:prefLabel	"glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase"
RHEA:16213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP
RHEA:16213	skos:altLabel	"alpha-N-acetylglucosaminyltransferase II"
RHEA:16213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase"
RHEA:16213	skos:altLabel	"glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase"
RHEA:66729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate
REACT:R-XTR-8862380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B13 binds lipid droplets (Xenopus tropicalis)
REACT:R-BTA-176494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to 27HCHOL (Bos taurus)
REACT:R-RNO-74718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalisation of the insulin receptor (Rattus norvegicus)
RHEA:53583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-6803063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial LPS, PGN (Danio rerio)
REACT:R-DRE-8854182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D17 binds OPTN:RAB8A (Danio rerio)
REACT:R-CEL-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Caenorhabditis elegans)
RHEA:42505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-acetyl-L-lysine => 6-acetamido-2-oxohexanoate + L-glutamate
RHEA:35100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fusidate(in) + H(+)(out) => fusidate(out) + H(+)(in)
REACT:R-HSA-879377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Homo sapiens)
REACT:R-CFA-3782637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC8 deacetylates histones (Canis familiaris)
GO:0102458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside
GO:0102458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose)"
GO:0102458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity
GO:0102458	skos:prefLabel	"cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose)"
GO:0004595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dephospho-coenzyme A pyrophosphorylase activity
GO:0004595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:pantetheine-4'-phosphate adenylyltransferase activity
GO:0004595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pantetheine-phosphate adenylyltransferase activity
GO:0004595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dephospho-CoA diphosphorylase activity
GO:0004595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantetheine phosphate adenylyltransferase activity
GO:0004595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-dephospho-CoA pyrophosphorylase activity
GO:0004595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopantetheine adenylyltransferase activity
GO:0004595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:pantetheine-phosphate adenylyltransferase activity
GO:0004595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dephospho-CoA pyrophosphorylase activity
GO:0004595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPAT activity
RHEA:14869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative
REACT:R-HSA-446701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)
REACT:R-DRE-9714477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the mitochondrial outer membrane (Danio rerio)
RHEA:22895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) <=> 5,10-methenyltetrahydrofolate + NADH
REACT:R-GGA-8964340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq-BTK complex dissociates to Active BTK and Gq (Gallus gallus)
REACT:R-MMU-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Mus musculus)
REACT:R-DDI-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)
REACT:R-SPO-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Schizosaccharomyces pombe)
RHEA:34242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate <=> 3-aminopentanedioate
REACT:R-DRE-1168642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Danio rerio)
REACT:R-DME-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Drosophila melanogaster)
REACT:R-SSC-2395869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
REACT:R-GGA-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Gallus gallus)
REACT:R-DDI-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Dictyostelium discoideum)
REACT:R-XTR-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Xenopus tropicalis)
REACT:R-DRE-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Danio rerio)
EC:1.5.1.30	skos:altLabel	"NADPH dehydrogenase (flavin)"
EC:1.5.1.30	skos:altLabel	"NADPH-dependent FMN reductase"
EC:1.5.1.30	skos:altLabel	"flavine mononucleotide reductase"
EC:1.5.1.30	skos:altLabel	"riboflavin mononucleotide reductase"
EC:1.5.1.30	skos:altLabel	"NADPH-FMN reductase"
EC:1.5.1.30	skos:altLabel	"FMN reductase (NADPH)"
EC:1.5.1.30	skos:altLabel	"riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase"
EC:1.5.1.30	skos:altLabel	"NADPH:riboflavin oxidoreductase"
EC:1.5.1.30	skos:altLabel	"riboflavine mononucleotide reductase"
EC:1.5.1.30	skos:altLabel	"flavin mononucleotide reductase"
EC:1.5.1.30	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavin reductase (NADPH)"
EC:1.5.1.30	skos:prefLabel	"flavin reductase (NADPH)"
EC:1.5.1.30	skos:altLabel	"NADPH-specific FMN reductase"
EC:1.5.1.30	skos:altLabel	"NADPH:flavin oxidoreductase"
EC:1.5.1.30	skos:altLabel	"NADPH-flavin reductase"
REACT:R-XTR-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Xenopus tropicalis)
REACT:R-RNO-5621571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD209 binds ICAM2 (Rattus norvegicus)
RHEA:50239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5653974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator binds Rag dimers (Bos taurus)
REACT:R-XTR-5423678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 hydroxylates AFB1 to AFM1 (Xenopus tropicalis)
RHEA:47241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:32611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeranial + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH
RHEA:20799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose <=> D-ribulose
REACT:R-DME-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Drosophila melanogaster)
REACT:R-DME-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Drosophila melanogaster)
RHEA:51112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Gallus gallus)
REACT:R-CFA-9624120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK2 (Canis familiaris)
REACT:R-DME-2870221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-selectin binds E-selectin ligand (Drosophila melanogaster)
REACT:R-XTR-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Xenopus tropicalis)
RHEA:28777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + hnu + oxidized dinoflagellate luciferin => dinoflagellate luciferin + O2
RHEA:10527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) <=> CO2 + succinate semialdehyde
REACT:R-HSA-6814387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP14 cleaves filaggrin (Homo sapiens)
GO:1901242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type doxorubicin transporter activity
GO:1901242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	doxorubicin transmembrane-transporting ATPase activity
GO:1901242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled doxorubicin transmembrane transporter activity
REACT:R-GGA-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Gallus gallus)
REACT:R-DRE-2176445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD2 (Danio rerio)
RHEA:44458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
REACT:R-HSA-9730501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 3CLpro dimer binds to STING (Homo sapiens)
RHEA:47789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 28S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Caenorhabditis elegans)
REACT:R-MMU-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Mus musculus)
REACT:R-RNO-377644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of CSK from SRC (Rattus norvegicus)
RHEA:46303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Drosophila melanogaster)
REACT:R-CFA-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Canis familiaris)
RHEA:38930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)
RHEA:31913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate => beta-D-fructose 1,6-bisphosphate + methylglyoxal
REACT:R-XTR-9695890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Xenopus tropicalis)
RHEA:36564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-colitose + NADP(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH
REACT:R-PFA-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-MMU-191636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cx43 by c-src (Mus musculus)
REACT:R-BTA-3165230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC52A1,2,3 transport RIB from extracellular region to cytosol (Bos taurus)
REACT:R-DME-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Drosophila melanogaster)
RHEA:69752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylmalonyl-CoA + H(+) + O2 => (E)-cinnamoyl-CoA + CO2 + H2O2
REACT:R-XTR-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Xenopus tropicalis)
RHEA:64455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine
RHEA:51647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADH + O2 <=> 7-dehydrocholesterol + 2 H2O + NAD(+)
RHEA:26178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+) => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine
REACT:R-HSA-1592371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP3 (Homo sapiens)
REACT:R-HSA-2130393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex along Golgi to TGN (Homo sapiens)
REACT:R-MMU-5218645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 binds p-Y397-PTK2 (Mus musculus)
RHEA:29550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N-acetyl-alpha-D-glucosamine <=> 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP
REACT:R-GGA-8854738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR binds CSFR (Gallus gallus)
REACT:R-BTA-2396370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds collagens II, III and V (Bos taurus)
GO:0070003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine-type peptidase activity
RHEA:19537	skos:prefLabel	"mannitol-1-phosphatase"
RHEA:19537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannitol-1-phosphatase"
RHEA:19537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol 1-phosphate + H2O = D-mannitol + phosphate
RHEA:64781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-benzyl-L-cysteine => 2-aminoprop-2-enoate + benzylthiol
RHEA:48468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1b (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate
RHEA:64088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA = 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O
REACT:R-SPO-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Schizosaccharomyces pombe)
REACT:R-BTA-193407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
REACT:R-DRE-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Danio rerio)
REACT:R-RNO-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Rattus norvegicus)
REACT:R-GGA-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Gallus gallus)
REACT:R-MMU-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Mus musculus)
RHEA:69956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + 3 Na(+)(out) => Ca(2+)(out) + 3 Na(+)(in)
REACT:R-CFA-5423672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)
REACT:R-DME-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Drosophila melanogaster)
REACT:R-CFA-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Canis familiaris)
REACT:R-HSA-8873946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD3 deubiquitinates PTEN (Homo sapiens)
RHEA:66108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-cysteine = (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate
REACT:R-SSC-9667965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds PP2A (Sus scrofa)
RHEA:16448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,4',7-trihydroxyisoflavanone <=> daidzein + H(+) + H2O
REACT:R-HSA-6804425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F2 (Homo sapiens)
REACT:R-GGA-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Gallus gallus)
REACT:R-BTA-83660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-anchored TNF-α binds TNFR1 (Bos taurus)
GO:0033890	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase D activity
GO:0033890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease D activity
RHEA:50135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl hexadecanoate + H2O <=> ethanol + H(+) + hexadecanoate
REACT:R-DME-5654605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS3 (Drosophila melanogaster)
REACT:R-BTA-9617370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-antagonists bind ADRA1A,B,D (Bos taurus)
REACT:R-CEL-1433508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC alpha interacts with and phosphorylates KIT (Caenorhabditis elegans)
RHEA:21365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(6-aminohexanoyl)-6-aminohexanoate => 2 6-aminohexanoate
REACT:R-XTR-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)
REACT:R-BTA-5649764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Bos taurus)
REACT:R-BTA-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Bos taurus)
RHEA:72615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-valine(out) = H(+)(in) + L-alanyl-L-valine(in)
RHEA:42040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)
RHEA:54178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-[ACP] + H(+) + NADPH => a long-chain fatty aldehyde + holo-[ACP] + NADP(+)
RHEA:37908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 => (8E,10S)-10-hydroperoxy-octadeca-8-enoate
REACT:R-CEL-8982617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB:O2 dissociates (Caenorhabditis elegans)
REACT:R-SSC-2424476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV2/3 (Sus scrofa)
RHEA:16225	skos:prefLabel	"6-aminohexanoate-cyclic-dimer hydrolase"
RHEA:16225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-aminohexanoate-cyclic-dimer hydrolase"
RHEA:16225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate
GO:0018693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethylbenzene dehydrogenase activity
GO:0018693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethylbenzene:(acceptor) oxidoreductase activity
GO:0018693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylbenzene hydroxylase activity
REACT:R-BTA-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Bos taurus)
RHEA:54503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> beta-geranylfarnesene + diphosphate
REACT:R-RNO-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-DME-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Drosophila melanogaster)
RHEA:31554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	presqualene diphosphate <=> 15-cis-4,4'-diapophytoene + diphosphate
REACT:R-DDI-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Dictyostelium discoideum)
REACT:R-CEL-73596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => dUMP + NH4+ (Caenorhabditis elegans)
REACT:R-CFA-202344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)
REACT:R-GGA-373750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:ErbB2 (Gallus gallus)
REACT:R-SPO-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Schizosaccharomyces pombe)
RHEA:72455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(out) + 3 H(+)(out) = fumarate(in) + 3 H(+)(in)
RHEA:66554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-serotonyl-L-glutamyl-[protein] + NH4(+) => L-glutaminyl-[protein] + serotonin
RHEA:67105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + fumigatonoid C + O2 => CO2 + H2O + novofumigatonin + succinate
RHEA:29836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactonate(in) + H(+)(in) => D-galactonate(out) + H(+)(out)
GO:0097158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-mRNA intronic pyrimidine-rich binding
GO:0097158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-messenger RNA intronic pyrimidine-rich binding
GO:0102589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity
GO:0005230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular ligand-gated ion channel activity
REACT:R-CFA-416683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA3E binds to PLXND1 (Canis familiaris)
REACT:R-CFA-5671707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Canis familiaris)
REACT:R-CFA-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Canis familiaris)
REACT:R-SCE-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Saccharomyces cerevisiae)
REACT:R-CEL-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Caenorhabditis elegans)
REACT:R-MMU-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Mus musculus)
RHEA:56648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-24-oyl-CoA + NAD(+) = 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH
RHEA:61095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-acetyl-L-citrulline <=> acetate + L-citrulline
REACT:R-XTR-1604712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP7 by trypsin (Xenopus tropicalis)
REACT:R-RNO-8851044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN1A1 binds xanthine oxidoreductase (XDH) (Rattus norvegicus)
EC:2.2.-.-	skos:prefLabel	"Transferring aldehyde or ketonic groups"
EC:2.2.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring aldehyde or ketonic groups"
REACT:R-HSA-5687088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates MAPKAPK5 (Homo sapiens)
REACT:R-RNO-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Rattus norvegicus)
GO:0050450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity
GO:0050450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate (Re)-synthase activity
GO:0050450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA]
GO:0050450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-citrate synthase activity
GO:0050450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]
GO:0050450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Re-citrate-synthase activity
RHEA:47672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-HSA-8875523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS3 (Homo sapiens)
REACT:R-SSC-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Sus scrofa)
GO:0047172	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity
GO:0047172	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	shikimate hydroxycinnamoyltransferase activity
GO:0047172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	shikimate O-hydroxycinnamoyltransferase activity
RHEA:69408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) = androst-4-ene-3,11,17-trione + H(+) + NADH
RHEA:15152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pyridoxine 5'-phosphate <=> H2O2 + pyridoxal 5'-phosphate
REACT:R-DRE-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Danio rerio)
REACT:R-DDI-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Dictyostelium discoideum)
RHEA:70107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-5-carboxymethyl-tetronate + o-quinone methide = H(+) + penilactone D
REACT:R-DME-165708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated 4EBP1 from eIF4E (Drosophila melanogaster)
REACT:R-HSA-8854905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)
REACT:R-CEL-177927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to EGF:EGFR:GRB2:GAB1 (Caenorhabditis elegans)
REACT:R-SPO-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Schizosaccharomyces pombe)
RHEA:50277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate
REACT:R-BTA-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Bos taurus)
RHEA:17129	skos:altLabel	"FGAM synthetase"
RHEA:17129	skos:altLabel	"formylglycinamide ribotide amidotransferase"
RHEA:17129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosylformylglycinamidine synthase"
RHEA:17129	skos:altLabel	"phosphoribosylformylglycinamidine synthetase"
RHEA:17129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate
RHEA:17129	skos:prefLabel	"phosphoribosylformylglycinamidine synthase"
RHEA:17129	skos:altLabel	"FGAM synthase"
RHEA:17129	skos:altLabel	"FGARAT"
RHEA:17129	skos:altLabel	"FGAR amidotransferase"
REACT:R-SSC-1878002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLTs transfer Xyl to core protein (Sus scrofa)
REACT:R-CFA-5661217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds zinc (Canis familiaris)
REACT:R-XTR-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Xenopus tropicalis)
RHEA:37384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-MMU-265422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaEbeta7 with Cadherin-1 (Mus musculus)
RHEA:14218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]
GO:0010291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carotene beta-ring hydroxylase activity
GO:0010291	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-carotene hydroxylase activity
RHEA:41361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
GO:0102508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3,7-diglucoside glucosidase activity
REACT:R-RNO-2172666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds condensin II (Rattus norvegicus)
RHEA:70322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + H2O <=> 1D-myo-inositol 3,4-bisphosphate + phosphate
REACT:R-CFA-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Canis familiaris)
REACT:R-MMU-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Mus musculus)
REACT:R-SCE-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)
REACT:R-DRE-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Danio rerio)
RHEA:12831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mesaconate + NH4(+) => (2S,3S)-3-methyl-L-aspartate
EC:2.7.7.6	skos:altLabel	"RNA nucleotidyltransferase (DNA-directed)"
EC:2.7.7.6	skos:altLabel	"DNA-dependent RNA polymerase"
EC:2.7.7.6	skos:prefLabel	"DNA-directed RNA polymerase"
EC:2.7.7.6	skos:altLabel	"RNA polymerase III"
EC:2.7.7.6	skos:altLabel	"RNA polymerase I"
EC:2.7.7.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA-directed RNA polymerase"
EC:2.7.7.6	skos:altLabel	"RNA polymerase II"
REACT:R-DRE-1855202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Danio rerio)
REACT:R-CFA-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Canis familiaris)
REACT:R-XTR-873951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1:HSP90 binds inactive NLRP3 (Xenopus tropicalis)
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transcription factor
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
GO:0000981	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
REACT:R-SPO-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Schizosaccharomyces pombe)
REACT:R-SCE-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Saccharomyces cerevisiae)
GO:0032562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP binding
RHEA:61172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP
REACT:R-CFA-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Canis familiaris)
RHEA:29575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)
RHEA:28510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arbutin 6-phosphate + H2O = beta-D-glucose 6-phosphate + hydroquinone
REACT:R-BTA-879909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of STAT5a/b by JAK2 (Bos taurus)
REACT:R-GGA-419214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) (Gallus gallus)
RHEA:22101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dibromo-4-hydroxybenzonitrile + 2 H2O => 3,5-dibromo-4-hydroxybenzoate + NH4(+)
REACT:R-MMU-195664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Mus musculus)
REACT:R-DRE-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Danio rerio)
RHEA:55206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+) => 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine
RHEA:54370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin + CO2 => acetaldehyde + H(+) + pyruvate
REACT:R-XTR-8982617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB:O2 dissociates (Xenopus tropicalis)
GO:0140333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophospholipid flippase activity (exoplasmic to cytosolic leaftlet)
GO:0140333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophospholipid flippase activity
REACT:R-CEL-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Caenorhabditis elegans)
REACT:R-CFA-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)
RHEA:68005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chloroethene => A + chloride + ethene + H(+)
GO:0015504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytosine permease activity
GO:0015504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine:proton symporter activity
GO:0015504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine:hydrogen ion symporter activity
RHEA:53685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
GO:0050614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D24-sterol reductase activity
GO:0050614	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lanosterol Delta(24)-reductase activity
GO:0050614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lanosterol delta24-reductase activity
GO:0050614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta24-sterol reductase activity
GO:0050614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol:NADP+ delta24-oxidoreductase activity
GO:0050614	skos:altLabel	"lanosterol Delta(24)-reductase"
GO:0050614	skos:prefLabel	"Delta(24)-sterol reductase"
GO:0050614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Delta(24)-sterol reductase"
REACT:R-HSA-8944254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVI (Homo sapiens)
RHEA:39546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)
RHEA:32408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S,4S)-neoisodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH
RHEA:42162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + AH2 + O2
REACT:R-HSA-9020260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5 (Homo sapiens)
RHEA:53609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + O2 => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)
RHEA:58106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O
GO:0090430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl-CoA: alcohol caffeoyl transferase activity
REACT:R-PFA-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Plasmodium falciparum)
REACT:R-XTR-4411402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NLK (Xenopus tropicalis)
REACT:R-BTA-1497869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - Sepiapterin is reduced to BH2 (Bos taurus)
REACT:R-HSA-977271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of EBF1 (Homo sapiens)
RHEA:19179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3,6-diaminohexanoate => L-lysine
RHEA:66866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + quiannulatene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate
RHEA:42770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H(+) + NADPH => a (2S)-2-hydroxycarboxylate + NADP(+)
REACT:R-CEL-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Caenorhabditis elegans)
REACT:R-SCE-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Saccharomyces cerevisiae)
RHEA:57111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:72234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) <=> chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)
RHEA:45146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + CO2 + CoA + methanethiol => 3-(methylsulfanyl)acryloyl-CoA + 2 H2O
RHEA:42336	skos:prefLabel	"ferredoxin:thioredoxin reductase"
RHEA:42336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin:thioredoxin reductase"
RHEA:42336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:12829	skos:prefLabel	"methylaspartate ammonia-lyase"
RHEA:12829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylaspartate ammonia-lyase"
RHEA:12829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)
RHEA:12829	skos:altLabel	"beta-methylaspartase"
RHEA:68271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + formaldehyde + H(+) + NADPH <=> dTMP + H2O + NADP(+)
REACT:R-DDI-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Dictyostelium discoideum)
REACT:R-MMU-198955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR complex interacts with peptide antigen-presenting MHC Class I (Mus musculus)
RHEA:44193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexadecanoate + ATP + CoA => 2-methylhexadecanoyl-CoA + AMP + diphosphate
REACT:R-SPO-1676204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Schizosaccharomyces pombe)
RHEA:25444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(E,E)-germacrene B synthase"
RHEA:25444	skos:prefLabel	"(E,E)-germacrene B synthase"
RHEA:25444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (1E,4E)-germacrene B + diphosphate
REACT:R-XTR-9708430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 (CRM1) binds to BACH1:Hemes (Xenopus tropicalis)
GO:0005093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rab GDP-dissociation inhibitor activity
REACT:R-CFA-5654714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
RHEA:13676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein-PII]-L-tyrosine + UTP <=> [protein-PII]-uridylyl-L-tyrosine + diphosphate
RHEA:41954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate
GO:1990534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thermospermine oxidase activity
REACT:R-RNO-3361751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin is replaced by repression complexes at the promoter (Rattus norvegicus)
RHEA:28867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + lactose(in) = H(+)(out) + lactose(out)
GO:0050106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monomethyl-sulfatase activity
GO:0050106	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monomethyl-sulfate sulfohydrolase activity
GO:0050106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monomethyl-sulphatase activity
REACT:R-DRE-9714483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the ER membrane (Danio rerio)
REACT:R-DME-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Drosophila melanogaster)
REACT:R-BTA-5683385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of BRCA1-A complex at DNA DSBs (Bos taurus)
REACT:R-RNO-8950485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Rattus norvegicus)
RHEA:16830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + O2 => a carboxylate + H(+) + H2O2
REACT:R-CEL-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Caenorhabditis elegans)
GO:0008140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cAMP response element binding protein binding
GO:0008140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-cyclophosphate response element binding protein binding
GO:0008140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CBP
GO:0008140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic AMP response element binding protein binding
GO:0008140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5' cAMP response element binding protein binding
GO:0008140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB binding
GO:0008140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP response element binding protein binding
REACT:R-RNO-5617179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates TNNI3 (Rattus norvegicus)
REACT:R-XTR-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Xenopus tropicalis)
RHEA:70499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(out) + 2 Na(+)(out) = D-galactose(in) + 2 Na(+)(in)
REACT:R-BTA-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)
REACT:R-MMU-209765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)
REACT:R-RNO-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Rattus norvegicus)
RHEA:37284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-histidine => L-alanine + L-histidine
RHEA:30533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin + H2O + NAD(+) => biotinate sulfoxide + H(+) + NADH
RHEA:19527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,8aR)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:67713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P-450 reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADPH--ferrihemoprotein reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-cytochrome P-450 oxidoreductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TPNH-cytochrome c reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH-hemoprotein reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:hemoprotein oxidoreductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferrihemoprotein P-450 reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADP--cytochrome c reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADPH--cytochrome c oxidoreductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:P-450 reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADPH-dependent cytochrome c reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH:cytochrome P450 reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADPH:P450 reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADPH--cytochrome c reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADPH--cytochrome P450 oxidoreductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADPH--cytochrome P450 reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD-cytochrome c reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TPNH(2) cytochrome c reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADP--cytochrome reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH:cytochrome c reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADPH--ferricytochrome c oxidoreductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPR activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-cytochrome p-450 reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:ferrihemoprotein oxidoreductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH-ferrihemoprotein reductase activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	POR
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde reductase (NADPH-dependent) activity
GO:0003958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPNH2 cytochrome c reductase activity
RHEA:12359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate <=> D-fructose 6-phosphate
REACT:R-PFA-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Plasmodium falciparum)
REACT:R-SSC-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Sus scrofa)
RHEA:33570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ethanol <=> acetaldehyde + AH2
REACT:R-HSA-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Homo sapiens)
RHEA:36572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + tetradecanoyl-CoA => CoA + H(+) + N-(tetradecanoyl)-sphinganine
REACT:R-CFA-1606839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Steryl sulfatase hydrolyses sulfate from steroid sulfates (Canis familiaris)
RHEA:61469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in tRNA + S-adenosyl-L-methionine => a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Caenorhabditis elegans)
REACT:R-SCE-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Saccharomyces cerevisiae)
REACT:R-CEL-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Caenorhabditis elegans)
RHEA:42056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + NAD(+) = 13-cis-retinal + H(+) + NADH
RHEA:28857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + melibiose(out) => H(+)(in) + melibiose(in)
RHEA:61138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + H2O + quercetin + succinate => (2R,3R)-dihydroquercetin + 2-oxoglutarate + O2
RHEA:20544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)
RHEA:64891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[ACP] + tetradecanoate <=> AMP + diphosphate + tetradecanoyl-[ACP]
REACT:R-PFA-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Plasmodium falciparum)
REACT:R-DRE-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Danio rerio)
REACT:R-DRE-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Danio rerio)
REACT:R-DME-2424487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)
REACT:R-XTR-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Xenopus tropicalis)
GO:0002145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMP-PP pyrophosphatase
GO:0002145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMP-PP diphosphatase
GO:0002145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
RHEA:51275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-octadecenoyl)glycine
REACT:R-HSA-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Homo sapiens)
RHEA:28894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + putrescine(in) <=> H(+)(out) + putrescine(out)
RHEA:10068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"poly(ribitol-phosphate) beta-glucosyltransferase"
RHEA:10068	skos:altLabel	"UDP-D-glucose polyribitol phosphate glucosyl transferase"
RHEA:10068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
RHEA:10068	skos:prefLabel	"poly(ribitol-phosphate) beta-glucosyltransferase"
REACT:R-CFA-5205681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is cleaved on healthy mitochondria (Canis familiaris)
REACT:R-HSA-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Homo sapiens)
REACT:R-XTR-211904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F12 18-hydroxylates ARA (Xenopus tropicalis)
GO:0050556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetylisoipecoside dopamine-lyase activity
GO:0050556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylisoipecoside synthase activity
GO:0050556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetylisoipecoside dopamine-lyase (secologanin-forming)
REACT:R-BTA-6813626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEAP2 binds bacteria (Bos taurus)
RHEA:23181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + O2 => a ketone + H2O2
RHEA:64666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]
REACT:R-CEL-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Caenorhabditis elegans)
REACT:R-SSC-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Sus scrofa)
RHEA:54105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-CFA-8938867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND3,(CCND1,CCND2) binds RUNX1 (Canis familiaris)
RHEA:16859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine
RHEA:39498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)
RHEA:51097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-5694494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)
REACT:R-CEL-9759154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM21 ubiquitinates SQSTM1 (Caenorhabditis elegans)
RHEA:60828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-adenosine in mRNA + H2O = a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate
GO:0019707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + L-cysteinyl-[protein] = an S-acyl-L-cysteinyl-[protein] + CoA
GO:0019707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-cysteine S-acyltransferase activity
REACT:R-BTA-1638803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)
GO:0106142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	25S rRNA m(1)A(645) methyltransferase
GO:0106142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	25S rRNA (adenine(645)-N(1))-methyltransferase
GO:0106142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (adenine-N1-)-methyltransferase activity
RHEA:24775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + NADP(+) <=> chlorophyllide b + H(+) + NADPH
REACT:R-DME-8982641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Drosophila melanogaster)
REACT:R-CEL-8985591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2-bound ROBO1 binds MYO9B (Caenorhabditis elegans)
REACT:R-HSA-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Homo sapiens)
REACT:R-DRE-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Danio rerio)
REACT:R-GGA-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Gallus gallus)
REACT:R-DME-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Drosophila melanogaster)
REACT:R-DME-373714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-Heterodimerization of nephrin and KIRREL (Drosophila melanogaster)
REACT:R-BTA-5422942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXRA:PPARD binds FABP5:atRA (Bos taurus)
REACT:R-SPO-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)
REACT:R-HSA-6788523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)
RHEA:25682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-429714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Homo sapiens)
REACT:R-DRE-217258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO2:FAD:Mg2+ S-oxidises MTZ (Danio rerio)
REACT:R-HSA-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Homo sapiens)
REACT:R-CFA-70577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)
REACT:R-RNO-199935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates CREB (Rattus norvegicus)
GO:0016205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenocysteine methyltransferase activity
RHEA:49147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate
REACT:R-CEL-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Caenorhabditis elegans)
RHEA:69836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate
RHEA:10092	skos:altLabel	"3'-deoxynucleotidase"
RHEA:10092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxynucleotide 3'-phosphatase"
RHEA:10092	skos:prefLabel	"deoxynucleotide 3'-phosphatase"
REACT:R-SSC-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Sus scrofa)
REACT:R-GGA-451466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binding to activated IRAK2 stimulates its oligomerization (Gallus gallus)
GO:0103007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetate carboxyl methyltransferase activity
REACT:R-MMU-2993780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO1 from E1 to UBE2I (UBC9) (Mus musculus)
RHEA:45642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O
RHEA:53954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate => 4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate
REACT:R-GGA-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Gallus gallus)
REACT:R-XTR-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Xenopus tropicalis)
REACT:R-HSA-2671873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)
RHEA:71318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-serine(out) + 2 Na(+)(out) <=> chloride(in) + L-serine(in) + 2 Na(+)(in)
REACT:R-BTA-5654615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:pFRS binds GRB2:SOS1 (Bos taurus)
RHEA:41293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + sphing-4-enine => H2O + N-dodecanoylsphing-4-enine
REACT:R-CFA-140599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Canis familiaris)
REACT:R-CFA-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Canis familiaris)
REACT:R-MMU-391937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP/CysLT receptor can bind cysteinyl leukotrienes (Mus musculus)
REACT:R-HSA-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Homo sapiens)
REACT:R-MMU-6807826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDHAL6B reduces PYR to LACT (Mus musculus)
GO:0050166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-pantoate:NAD+ 4-oxidoreductase activity
GO:0050166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	panthothenase activity
GO:0050166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantoate dehydrogenase activity
GO:0050166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-pantoate:NAD+ 4-oxidoreductase activity
GO:0050166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pantoate 4-dehydrogenase activity
REACT:R-DRE-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Danio rerio)
REACT:R-HSA-450551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 binds translation and heat shock proteins (Homo sapiens)
REACT:R-BTA-8858298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRASLS transfer acyl group from PC to PE to form NAPE (Bos taurus)
RHEA:54469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate
REACT:R-CFA-2247510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARCO:ligand is endocytosed (Canis familiaris)
RHEA:34881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxy-4-oxo-3-phenylbutanoate + NH4(+) => 2 H2O + methyl 3-cyano-2-phenylpropanoate
REACT:R-XTR-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Xenopus tropicalis)
RHEA:56244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]
RHEA:43375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + dTDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)
RHEA:20542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 => 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)
REACT:R-HSA-5696465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP45 deubiquitinates ERCC1 (Homo sapiens)
REACT:R-SSC-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Sus scrofa)
REACT:R-DDI-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Dictyostelium discoideum)
REACT:R-MMU-6806957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET receptor dimerizes (Mus musculus)
REACT:R-CEL-9640175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Caenorhabditis elegans)
RHEA:16178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + retinal => 2 H(+) + NADH + retinoate
REACT:R-MMU-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Mus musculus)
REACT:R-MMU-201648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, Endofin, recruits R-Smad1/5/8 (Mus musculus)
REACT:R-XTR-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)
REACT:R-SSC-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Sus scrofa)
RHEA:65475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + ethanol <=> CoA + ethyl 2-methylbutanoate
REACT:R-GGA-873922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 by JAK kinases (Gallus gallus)
RHEA:20192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + NAD(+) <=> H(+) + NADH + uracil
REACT:R-CEL-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Caenorhabditis elegans)
REACT:R-RNO-1475414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Rattus norvegicus)
RHEA:22684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 = (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O
RHEA:22684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase"
RHEA:22684	skos:prefLabel	"4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase"
REACT:R-HSA-5662622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1X binds cadmium (Homo sapiens)
RHEA:27944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + oxaloacetate => (3R)-3-hydroxy-D-aspartate
RHEA:63369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + spermine(out) => ADP + H(+) + phosphate + spermine(in)
RHEA:37049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-histidine(in) => H(+)(out) + L-histidine(out)
REACT:R-DRE-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Danio rerio)
REACT:R-DDI-265296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Dictyostelium discoideum)
REACT:R-BTA-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Bos taurus)
RHEA:39564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)
RHEA:18239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-maleylpyruvate + H(+) => 2,5-dihydroxybenzoate + O2
REACT:R-DRE-9749197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 binds to H4K20me2 (Danio rerio)
RHEA:50525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]
REACT:R-DRE-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Danio rerio)
REACT:R-HSA-5686398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPIDR binds BLM:TOP3A:RMI1:RMI2 (Homo sapiens)
REACT:R-RNO-444879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 2 binds relaxin 2 and INSL3 (Rattus norvegicus)
REACT:R-CEL-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Caenorhabditis elegans)
RHEA:61824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pregnenolone + UDP-alpha-D-glucose = H(+) + pregnenolone 3-beta-D-glucoside + UDP
REACT:R-DME-390251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Drosophila melanogaster)
RHEA:62822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O => 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:57955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + phenol <=> catechol + H2O + NAD(+)
REACT:R-DRE-5632668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMO translocates to the cilium (Danio rerio)
GO:0016887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-triphosphatase activity
GO:0016887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolase activity
GO:0016887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine triphosphatase activity
GO:0016887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis activity
GO:0016887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP phosphohydrolase activity
GO:0016887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosinetriphosphatase activity
GO:0016887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP monophosphatase activity
RHEA:56982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin] => 4-hydroxybenzyl alcohol + 2 oxidized [azurin]
RHEA:47784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-5654163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds PLCG1 (Xenopus tropicalis)
REACT:R-BTA-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Bos taurus)
RHEA:40018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O <=> 13-epi-manool + diphosphate
RHEA:32633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin C + H2O + NADP(+) => erythromycin D + H(+) + NADPH + O2
REACT:R-XTR-975903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Xenopus tropicalis)
REACT:R-HSA-1655836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Diphosphomevalonate Decarboxylase (MVD) (Homo sapiens)
RHEA:58965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanal + O2 => H(+) + H2O2 + hexanoate
RHEA:26532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + H2O => 4-hydroxybutanoyl-CoA
REACT:R-CEL-1454781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Caenorhabditis elegans)
REACT:R-GGA-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Gallus gallus)
RHEA:25857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:57189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glycolate + H(+) + L-arginyl-[protein]
RHEA:33742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoate + NADH <=> H2O + hexadecanal + NAD(+)
EC:3.4.11.1	skos:altLabel	"leucine aminopeptidase"
EC:3.4.11.1	skos:altLabel	"cytosol aminopeptidase"
EC:3.4.11.1	skos:altLabel	"peptidase S"
EC:3.4.11.1	skos:prefLabel	"leucyl aminopeptidase"
EC:3.4.11.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leucyl aminopeptidase"
REACT:R-BTA-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Bos taurus)
REACT:R-GGA-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Gallus gallus)
REACT:R-GGA-422017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase decanoylates Proghrelin (Gallus gallus)
REACT:R-MMU-1013020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Mus musculus)
RHEA:32720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:45056	skos:altLabel	"12-deoxynogalonic acid oxidoreductase"
RHEA:45056	skos:prefLabel	"deoxynogalonate monooxygenase"
RHEA:45056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxynogalonate monooxygenase"
RHEA:45056	skos:altLabel	"12-deoxynogalonic acid monooxygenase"
RHEA:45056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxynogalonate + O2 = H(+) + H2O + nogalonate
RHEA:45056	skos:altLabel	"deoxynogalonate oxidase"
REACT:R-DME-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Drosophila melanogaster)
REACT:R-MMU-1474213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP1,8,9,13 (Mus musculus)
RHEA:35036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) => 4-aminobutanoate(out)
REACT:R-DDI-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Dictyostelium discoideum)
REACT:R-SSC-420131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PACAP receptor binds PACAP (Sus scrofa)
REACT:R-SSC-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Sus scrofa)
REACT:R-SSC-8866308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL translocates from RER membrane to SER lumen (Sus scrofa)
RHEA:69251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sinigrin <=> (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)
REACT:R-DRE-9731661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Danio rerio)
REACT:R-RNO-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Rattus norvegicus)
RHEA:16835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + 2 H2O => 2 glutathione + H2O2
RHEA:46608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
GO:0102350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-cerot-2-enoyl-CoA reductase activity
REACT:R-DDI-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)
RHEA:56625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)
REACT:R-DME-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
RHEA:67028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O = (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate
RHEA:23830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-D-gluconate + NADP(+)
RHEA:60450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + S-substituted gamma-glutamyl-L-cysteine => an S-substituted glutathione + H2O
RHEA:54446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3R)-dihydroflavonol + H(+) + NADPH => a (2R,3S,4S)-leucoanthocyanidin + NADP(+)
RHEA:49739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NAD(+)
REACT:R-CFA-352232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)
REACT:R-SSC-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Sus scrofa)
REACT:R-BTA-1370505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR is phosphorylated at Ser-349 (Bos taurus)
REACT:R-BTA-5676592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xRANK binds RANKL,sRANKL trimer:RANK (Bos taurus)
RHEA:51089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0106262	skos:altLabel	"lysophosphatidylethanolamine acyltransferase"
GO:0106262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
GO:0106262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acylglycerophosphoethanolamine O-acyltransferase activity
GO:0106262	skos:prefLabel	"1-acylglycerophosphoethanolamine O-acyltransferase"
GO:0106262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-acylglycerophosphoethanolamine O-acyltransferase"
REACT:R-MMU-997311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of TYK2 by PTP1B (Mus musculus)
RHEA:29557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose
REACT:R-HSA-9769323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 stimulates NAMPT gene expression (Homo sapiens)
REACT:R-BTA-6805479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53RK phosphorylates TP53 (Bos taurus)
REACT:R-DME-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
RHEA:33336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctadecanoyl-sn-glycerol + phosphate
REACT:R-HSA-380942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)
RHEA:40937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+) => a 1-acylglycerone 3-phosphate + hexadecan-1-ol
REACT:R-HSA-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
REACT:R-DRE-349444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of COP1 at Ser-387  by ATM (Danio rerio)
GO:1901375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate ester transmembrane transporter activity
RHEA:10190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+) => acetoacetyl-CoA + acetyl-CoA + H2O
EC:1.14.14.19	skos:altLabel	"CYP17A1"
EC:1.14.14.19	skos:altLabel	"steroid 17alpha-hydroxylase"
EC:1.14.14.19	skos:prefLabel	"steroid 17alpha-monooxygenase"
EC:1.14.14.19	skos:altLabel	"CYP17"
EC:1.14.14.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steroid 17alpha-monooxygenase"
EC:1.14.14.19	skos:altLabel	"steroid 17alpha-hydroxylase/17,20 lyase"
EC:1.14.14.19	skos:altLabel	"cytochrome p450 XVIIA1"
RHEA:17900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ethylbenzene + H2O <=> (S)-1-phenylethanol + AH2
RHEA:45866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA
REACT:R-RNO-165758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and inactivation of eEF2K by activated S6K1 (Rattus norvegicus)
REACT:R-DRE-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Danio rerio)
GO:0030744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin O-methyltransferase activity
GO:0030744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	luteolin 3'-O-methyltransferase activity
GO:0030744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	luteolin methyltransferase activity
GO:0030744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-dihydric phenol meta-O-methyltransferase activity
GO:0030744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity
GO:0030744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity
GO:0030744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-dihydric phenol methyltransferase activity
GO:0030744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-diphenol m-O-methyltransferase activity
REACT:R-DDI-379382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)
REACT:R-SSC-204798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and p85 of PI3K (Sus scrofa)
REACT:R-HSA-5675206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEA15 binds MAPK monomers and dimers (Homo sapiens)
REACT:R-XTR-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Xenopus tropicalis)
RHEA:61602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbB protein]-dithiol + [protein]-disulfide => [DsbD protein]-disulfide + [protein]-dithiol
REACT:R-BTA-1433428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2 is indirectly recruited to p-KIT through SHP2 (Bos taurus)
REACT:R-RNO-4647593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP400 binds CDKN1A promoter (Rattus norvegicus)
RHEA:14253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H(+)
REACT:R-XTR-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Xenopus tropicalis)
GO:0008884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathionylspermidine amidohydrolase (spermidine-forming) activity
GO:0008884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathionylspermidine amidase activity
GO:0008884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity
GO:0008884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GSP amidase activity
REACT:R-HSA-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Homo sapiens)
RHEA:27630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylene glycol + NAD(+) = glycolaldehyde + H(+) + NADH
RHEA:65366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O
RHEA:49732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O2 + violaceinate = CO2 + H2O + violacein
REACT:R-MMU-5419281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRRF binds 55S ribosome:mRNA:tRNA (Mus musculus)
REACT:R-MMU-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Mus musculus)
RHEA:65877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androst-1-ene-3,17-dione + H2O => 1-hydroxy-5alpha-androstan-3,17-dione
REACT:R-RNO-1606288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Rattus norvegicus)
RHEA:11866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein] => H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine
RHEA:27623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + 7 isopentenyl diphosphate => 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate
REACT:R-SSC-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Sus scrofa)
REACT:R-MMU-9749505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC14 binds IKBKB and CHUK (Mus musculus)
RHEA:39601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH
REACT:R-RNO-4420143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SH2D2A (Rattus norvegicus)
REACT:R-SSC-9664881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Sus scrofa)
REACT:R-RNO-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Rattus norvegicus)
REACT:R-MMU-2168883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin:Hemoglobin binds CD163 (Mus musculus)
REACT:R-MMU-8868659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
REACT:R-SSC-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Sus scrofa)
RHEA:25671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + UDP-alpha-D-galactose => H(+) + loliose + UDP
REACT:R-CEL-389995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Caenorhabditis elegans)
RHEA:22429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 => 2 H2O + isopenicillin N
REACT:R-XTR-1181149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Xenopus tropicalis)
RHEA:69346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-butanethial oxide => (E)-but-1-en-1-SO-peroxol
REACT:R-DME-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Drosophila melanogaster)
RHEA:34117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine => carboxynorspermidine + H2O + NADP(+)
REACT:R-HSA-9615501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR132 gene expression is stimulated by p-S133-CREB1 (Homo sapiens)
REACT:R-CEL-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Caenorhabditis elegans)
RHEA:43509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diformylfuran + H2O => 2-(dihydroxymethyl)-5-formylfuran
RHEA:38890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexanoyl-sphinganine <=> hexanoate + sphinganine
RHEA:16395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + juvenile hormone II carboxylate + methanol => H2O + juvenile hormone II
REACT:R-XTR-1980122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX binds NOTCH1 (Xenopus tropicalis)
GO:0019798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	procollagen-proline dioxygenase activity
RHEA:14417	skos:altLabel	"lysine N(6)-acetyltransferase"
RHEA:14417	skos:altLabel	"LAT"
RHEA:14417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + L-lysine = H(+) + N(6)-acetyl-L-lysine + phosphate
RHEA:14417	skos:altLabel	"lysine acetyltransferase"
RHEA:14417	skos:prefLabel	"lysine N-acetyltransferase"
RHEA:14417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine N-acetyltransferase"
REACT:R-MMU-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Mus musculus)
RHEA:21641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH
RHEA:62863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 H(+) + 7 malonyl-CoA <=> 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O
REACT:R-RNO-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Rattus norvegicus)
REACT:R-SCE-3780997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG2:GYS2 (Saccharomyces cerevisiae)
RHEA:23033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate
REACT:R-DRE-9012349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)
RHEA:52015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
RHEA:55142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + D-alanyl-[D-alanyl-carrier protein] + H(+) => D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein]
RHEA:18363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) => a dolichyl D-xylosyl phosphate + L-seryl-[protein]
RHEA:31790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tuberculosinyl diphosphate <=> (13R)-edaxadiene + diphosphate
REACT:R-RNO-193054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cholesterol to 22beta-hydroxycholesterol (Rattus norvegicus)
RHEA:54286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-octadecanoylsphing-4-enine + phosphocholine => H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine
RHEA:28727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(in) + H(+)(in) = Cu(2+)(out) + H(+)(out)
RHEA:71826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodo-L-thyronine(out) <=> 3,3'-diiodo-L-thyronine(in)
RHEA:21711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-adenosyl-L-homocysteine <=> adenosine + L-homocysteine
REACT:R-DME-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Drosophila melanogaster)
REACT:R-MMU-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
REACT:R-SSC-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Sus scrofa)
REACT:R-HSA-4608825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)
REACT:R-HSA-9647999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCE1 cleaves S-Farn proRAS proteins (Homo sapiens)
RHEA:53508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate
RHEA:58989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H2O + O2 => (E)-4-hydroxynon-2-enoate + H(+) + H2O2
RHEA:43430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-didecanoyl-sn-glycerol + ATP
RHEA:22606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose => D-mannose
REACT:R-SCE-2430535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL phosphorylates ENSA (Saccharomyces cerevisiae)
RHEA:30918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine
GO:0008490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite secondary active transmembrane transporter activity
GO:0008490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenite porter activity
REACT:R-BTA-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Bos taurus)
GO:0051287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD binding
GO:0051287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+ or NADH binding
GO:0051287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD or NADH binding
GO:0051287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide adenine dinucleotide binding
RHEA:57595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Sus scrofa)
GO:0039706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	co-receptor binding
REACT:R-HSA-9623365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of MYLIP regulated by NR1H2,3 (Homo sapiens)
REACT:R-XTR-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Xenopus tropicalis)
REACT:R-RNO-9029566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Rattus norvegicus)
RHEA:37842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-GGA-9681294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6R binds IL6R inhibitors (Gallus gallus)
REACT:R-MMU-73739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)
RHEA:37573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine
GO:0140775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin debranching activity
GO:0140775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin filament debranching activity
REACT:R-HSA-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Homo sapiens)
RHEA:27291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + formate + H(+) => AH2 + CO2
REACT:R-DRE-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Danio rerio)
REACT:R-HSA-4084984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Homo sapiens)
REACT:R-RNO-5635861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH binds GLI1 (Rattus norvegicus)
RHEA:48569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chlorocatechol + O2 => (2E,4Z)-2-chloromuconate + 2 H(+)
REACT:R-DME-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Drosophila melanogaster)
REACT:R-MMU-9647746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 trimerizes (Mus musculus)
REACT:R-XTR-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Xenopus tropicalis)
REACT:R-GGA-8851827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Gallus gallus)
REACT:R-BTA-158609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers CH3 from AdoMet to 6MP (Bos taurus)
REACT:R-BTA-9029690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-6 translocates to the nucleus (Bos taurus)
RHEA:12156	skos:prefLabel	"2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase"
RHEA:12156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase"
RHEA:12156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH
RHEA:12156	skos:altLabel	"4-hydroxy-3-glutathionyl-3-methylbut-1-ene dehydrogenase"
REACT:R-SSC-83650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FasL:Fas binds FADD (Sus scrofa)
REACT:R-DDI-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Dictyostelium discoideum)
REACT:R-RNO-8853789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDNF,NRTN bind RET:GFRA1,GFRA2 (Rattus norvegicus)
RHEA:20079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(18) in tRNA + S-adenosyl-L-methionine
REACT:R-MMU-381135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Mus musculus)
RHEA:12471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenacoside A + H2O <=> 26-desgluco-avenacoside A + D-glucose
GO:0033451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine tRNA
GO:0033451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTA codon-amino acid adaptor activity
GO:0033451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUA codon-amino acid adaptor activity
RHEA:21552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
REACT:R-CFA-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Canis familiaris)
REACT:R-RNO-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Rattus norvegicus)
RHEA:29781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-methionine(in) + phosphate => ATP + H2O + L-methionine(out)
REACT:R-CFA-193713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Canis familiaris)
REACT:R-HSA-9026464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDNF-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)
REACT:R-HSA-9023346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds NOTCH1 gene promoter (Homo sapiens)
RHEA:65101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerol + hexadecanoyl-CoA => an hexadecanoyl-acylglycerol + CoA
RHEA:31447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-2-oxohexanoate + H2O2 = 5-aminopentanoate + CO2 + H2O
RHEA:53044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:30995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B
RHEA:38784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-MMU-9709454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR binds EPOR agonists (Mus musculus)
REACT:R-MMU-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Mus musculus)
RHEA:62354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + notoamide D => H(+) + NADPH + notoamide E + O2
RHEA:22690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NH4(+) + pyruvate => D-alanine + H2O + O2
REACT:R-CEL-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Caenorhabditis elegans)
RHEA:63812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)
REACT:R-HSA-8865626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dimers bind the BRWD1 gene promoter (Homo sapiens)
REACT:R-SSC-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Sus scrofa)
GO:0009784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor histidine kinase activity
GO:0047804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-S-conjugate beta-lyase activity
GO:0047804	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine conjugate beta-lyase activity
GO:0047804	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)
GO:0047804	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine transaminase K/cysteine conjugate beta-lyase activity
GO:0047804	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine-S-conjugate thiol-lyase (deaminating) activity
GO:0047804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-S-conjugate b-lyase activity
REACT:R-BTA-8847968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN binds FRK (Bos taurus)
RHEA:24143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:48637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O
REACT:R-SSC-5691439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRISC complex deubiquitinates NLRP3 (Sus scrofa)
REACT:R-XTR-77304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Xenopus tropicalis)
REACT:R-SSC-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Sus scrofa)
REACT:R-HSA-560491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CEBPA (Homo sapiens)
RHEA:66190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP(out) + ADP + H(+) + phosphate => 3',5'-cyclic GMP(in) + ATP + H2O
RHEA:40239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + dodecanedioate = AMP + diphosphate + dodecanedioyl-CoA
REACT:R-DRE-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Danio rerio)
REACT:R-RNO-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Rattus norvegicus)
RHEA:71172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-cysteine(out) + Na(+)(out) => H(+)(out) + L-cysteine(in) + Na(+)(in)
RHEA:33001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-2533944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP10 (Homo sapiens)
REACT:R-CEL-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Caenorhabditis elegans)
REACT:R-SPO-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Schizosaccharomyces pombe)
RHEA:19248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-phenylhydroxylamine <=> 2-aminophenol
RHEA:47749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H(+) + n Na(+)(in) + NADH => a ubiquinol + n Na(+)(out) + NAD(+)
RHEA:62611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + H(+) + hydrogen sulfide + ubiquinone-10 <=> S-sulfanylglutathione + ubiquinol-10
RHEA:37684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
RHEA:66270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + nonanoyl-CoA => CoA + nonanoyl-AMP
REACT:R-SSC-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Sus scrofa)
REACT:R-DME-937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 (Drosophila melanogaster)
RHEA:62698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cornusiin E + 2 H2O => O2 + 4 tellimagrandin II
RHEA:27658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate
REACT:R-HSA-210881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Tie2/Ang1 complex (Homo sapiens)
REACT:R-DDI-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)
RHEA:12006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indican + UDP => indoxyl + UDP-alpha-D-glucose
REACT:R-MMU-2002466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of allysine by LOX (Mus musculus)
RHEA:37173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA
RHEA:40962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
GO:0097004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKH binding
GO:0097004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adipokinetic hormone binding
REACT:R-RNO-8853419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 promotes AURKA autophosphorylation (Rattus norvegicus)
REACT:R-RNO-389532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A binds CTLA4 dimer (Rattus norvegicus)
REACT:R-DRE-9026408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Danio rerio)
REACT:R-CFA-5610742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI1 (Canis familiaris)
REACT:R-CEL-1475422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPS is phosphorylated by cGMP-dependant protein kinase II (Caenorhabditis elegans)
REACT:R-HSA-1031716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of IFNG-stimulated genes (Homo sapiens)
RHEA:27746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-cysteine = CO2 + cysteamine
REACT:R-RNO-139970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO3:FAD N-oxidises TMA to TMAO (Rattus norvegicus)
RHEA:16567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(imidazol-5-yl)pyruvate + L-glutamate => 2-oxoglutarate + L-histidine
RHEA:67125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxide + L-cysteinyl-[protein] => an alcohol + S-hydroxy-L-cysteinyl-[protein]
REACT:R-XTR-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Xenopus tropicalis)
RHEA:69842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-CoA + H2O => a (3S)-3-hydroxyacyl-CoA
REACT:R-DRE-77301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Danio rerio)
REACT:R-DRE-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Danio rerio)
RHEA:38725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol
REACT:R-MMU-8982165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Mus musculus)
RHEA:72548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + taurocholate(out) => 2-oxoglutarate(out) + taurocholate(in)
REACT:R-HSA-508292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds IL2RB (Homo sapiens)
RHEA:11916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + H(+) + NADH
REACT:R-DRE-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Danio rerio)
REACT:R-DRE-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Danio rerio)
REACT:R-DDI-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Dictyostelium discoideum)
REACT:R-HSA-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Homo sapiens)
REACT:R-XTR-437118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI stimulates PI3K beta, gamma (Xenopus tropicalis)
REACT:R-DRE-373738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin interacts with syntenin-1 (Danio rerio)
REACT:R-SSC-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Sus scrofa)
GO:0047674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-apiose reductase activity
GO:0047674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-apiitol:NAD+ 1-oxidoreductase activity
GO:0047674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-apiitol reductase activity
GO:0047674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apiose 1-reductase activity
REACT:R-CFA-201595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plakophilin-1 (Canis familiaris)
RHEA:45428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate
REACT:R-CEL-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Caenorhabditis elegans)
REACT:R-DDI-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Dictyostelium discoideum)
RHEA:38814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-DME-190268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to Klotho-bound FGF23 (Drosophila melanogaster)
RHEA:10627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + CO2 + H2O + NH4(+) <=> 2 ADP + carbamoyl phosphate + 3 H(+) + phosphate
RHEA:35924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP
RHEA:13013	skos:altLabel	"galactosyltransferase"
RHEA:13013	skos:altLabel	"alpha-galactosyltransferase"
RHEA:13013	skos:altLabel	"UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase"
RHEA:13013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:13013	skos:altLabel	"glucosaminylglycopeptide alpha-1,3-galactosyltransferase"
RHEA:13013	skos:altLabel	"UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase"
RHEA:13013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyllactosaminide 3-alpha-galactosyltransferase"
RHEA:13013	skos:altLabel	"beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase"
RHEA:13013	skos:prefLabel	"N-acetyllactosaminide 3-alpha-galactosyltransferase"
RHEA:13013	skos:altLabel	"UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase"
RHEA:13013	skos:altLabel	"uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase"
RHEA:13013	skos:altLabel	"uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase"
RHEA:13013	skos:altLabel	"uridine diphosphogalactose-acetyllactosamine galactosyltransferase"
RHEA:13013	skos:altLabel	"UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase"
RHEA:13013	skos:altLabel	"N-acetyllactosaminide alpha-1,3-galactosyltransferase"
REACT:R-CEL-204169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP dephosphorylates p-lipo-PDH (Caenorhabditis elegans)
RHEA:48840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
REACT:R-SSC-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Sus scrofa)
RHEA:24543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-glucose <=> AH2 + D-glucono-1,5-lactone
REACT:R-DRE-1592387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin binds elastic fibres (Danio rerio)
REACT:R-DME-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Drosophila melanogaster)
RHEA:32770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Gallus gallus)
REACT:R-CEL-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)
REACT:R-HSA-8939688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) complex binds RUNX2 (Homo sapiens)
REACT:R-HSA-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Homo sapiens)
REACT:R-HSA-9725030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner (Homo sapiens)
RHEA:28771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA = (9Z)-hexadecenoyl-CoA
REACT:R-GGA-6788392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Gallus gallus)
RHEA:49232	skos:prefLabel	"protein-N(pi)-phosphohistidine--D-mannose phosphotransferase"
RHEA:49232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--D-mannose phosphotransferase"
RHEA:49232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]
RHEA:49232	skos:altLabel	"mannose PTS permease"
REACT:R-CFA-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Canis familiaris)
REACT:R-HSA-6803998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitrite ion and HNO2 form a conjugated acid-base pair (Homo sapiens)
REACT:R-DRE-3249392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Danio rerio)
RHEA:45312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin H2
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine deoxyribonucleoside phosphorylase activity
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine ribonucleoside phosphorylase activity
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine deoxynucleoside phosphorylase activity
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PUNPII
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine-nucleoside phosphorylase activity
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PUNPI
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine-nucleoside:phosphate ribosyltransferase activity
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine-guanosine phosphorylase activity
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PNPase activity
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	inosine phosphorylase activity
GO:0004731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine nucleoside phosphorylase activity
RHEA:15360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <=> demethyllactenocin + dTDP + H(+)
REACT:R-CFA-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Canis familiaris)
RHEA:20168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-acyl-L-ornithine ester <=> an alcohol + H(+) + N(5)-acyl-L-ornithine
REACT:R-BTA-390438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR2 reduces PalmCoA to HXOL (Bos taurus)
RHEA:45546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Canis familiaris)
REACT:R-DME-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Drosophila melanogaster)
RHEA:18487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + D-glucose + H(+) => 6-acetyl-D-glucose + H2O
REACT:R-BTA-8867370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Bos taurus)
REACT:R-CFA-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Canis familiaris)
RHEA:29562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucuronate <=> 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP
REACT:R-GGA-5654597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Gallus gallus)
RHEA:21499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O <=> diphosphate + prenol
REACT:R-DRE-174121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Securin with Cdc20:APC/C complex (Danio rerio)
REACT:R-HSA-5668984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 or PAK2 phosphorylates MYLK (Homo sapiens)
RHEA:64199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-lysine + H2O <=> a fatty acid + L-lysine
REACT:R-DME-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Drosophila melanogaster)
REACT:R-CFA-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Canis familiaris)
REACT:R-SCE-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Saccharomyces cerevisiae)
RHEA:63364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2
REACT:R-DME-5610763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Drosophila melanogaster)
RHEA:18360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tropine <=> H(+) + NADPH + tropinone
REACT:R-DME-75879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Drosophila melanogaster)
REACT:R-HSA-375790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Homo sapiens)
RHEA:64384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine
REACT:R-SPO-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Schizosaccharomyces pombe)
REACT:R-GGA-8850777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK14 (Gallus gallus)
REACT:R-MMU-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Mus musculus)
RHEA:49807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropan-1-amine + FMNH2 + O2 <=> FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine
REACT:R-MMU-917693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESCRT Disassembly (Mus musculus)
REACT:R-MMU-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Mus musculus)
REACT:R-RNO-6786650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDHD1,2 hydrolyse PA (Rattus norvegicus)
REACT:R-DRE-159868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor VII to factor VII (Danio rerio)
REACT:R-HSA-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Homo sapiens)
RHEA:12283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
REACT:R-HSA-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Homo sapiens)
REACT:R-HSA-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Homo sapiens)
REACT:R-XTR-8853429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLDA1 binds AURKA (Xenopus tropicalis)
RHEA:56966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate
RHEA:25745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-pentahomomethionine
GO:0015098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdate transporter activity
GO:0015098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdate ion transmembrane transporter activity
REACT:R-RNO-9024334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Rattus norvegicus)
REACT:R-HSA-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Homo sapiens)
REACT:R-MMU-8848436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CDKN1B (Mus musculus)
REACT:R-RNO-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Rattus norvegicus)
REACT:R-CFA-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Canis familiaris)
RHEA:29813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + thiamine(in) => ATP + H2O + thiamine(out)
REACT:R-DRE-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Danio rerio)
RHEA:66413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)
GO:0072345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAADP-sensitive calcium-release channel activity
GO:0072345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPCN1/2 transport lysosomal Ca2+ to cytosol  (Homo sapiens)
REACT:R-GGA-8952062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 recruits HDAC4 to RUNX3 (Gallus gallus)
REACT:R-GGA-9679477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFA inhibitors (Gallus gallus)
RHEA:15275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-dopa
RHEA:43013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine => 2-aminobut-2-enoate + H(+) + hydrogen sulfide
GO:0050468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BBE
GO:0050468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydroprotoberberine synthase activity
GO:0050468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	berberine-bridge-forming enzyme activity
GO:0050468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reticuline oxidase activity
GO:0050468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)
GO:0050468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	berberine bridge enzyme activity
REACT:R-MMU-5654684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR4 (Mus musculus)
RHEA:63814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine) => ATP + N(8)-citryl-spermidine + spermidine
REACT:R-CFA-73932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resynthesis of excised residue by POLB (Canis familiaris)
RHEA:50357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-methylpretetramide + NADPH + O2 => 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)
RHEA:19482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + succinyl-CoA => 3-oxoadipyl-CoA + CoA
RHEA:18444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-dopachrome + H(+) <=> 5,6-dihydroxyindole + CO2
RHEA:37936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
REACT:R-PFA-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Plasmodium falciparum)
REACT:R-DME-209074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WG, FZ and ARR bind to each other (Drosophila melanogaster)
REACT:R-RNO-450358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Rattus norvegicus)
REACT:R-BTA-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Bos taurus)
REACT:R-HSA-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Homo sapiens)
RHEA:34611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose = H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP
REACT:R-GGA-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Gallus gallus)
REACT:R-BTA-139905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAD protein to mitochondria (Bos taurus)
RHEA:60097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH
REACT:R-XTR-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Xenopus tropicalis)
REACT:R-MMU-947531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Mus musculus)
REACT:R-CFA-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Canis familiaris)
REACT:R-MMU-9027275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Mus musculus)
REACT:R-GGA-5627071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Gallus gallus)
REACT:R-SSC-3318413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Sus scrofa)
REACT:R-DRE-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Danio rerio)
REACT:R-HSA-1655850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
REACT:R-DRE-1013020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Danio rerio)
REACT:R-SPO-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Schizosaccharomyces pombe)
REACT:R-BTA-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Bos taurus)
GO:0034904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-chloro-2-oxopent-4-enoate hydratase activity
REACT:R-GGA-193694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 is recruited and forms a complex with TRAF6 (Gallus gallus)
GO:0008507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:iodide symporter activity
GO:0008507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/iodide symporter activity
REACT:R-DRE-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Danio rerio)
REACT:R-DRE-5690245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 binds DNAJB1 (Danio rerio)
REACT:R-SSC-1592316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP1 (Sus scrofa)
RHEA:31574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + NADP(+) + naphthalene-1,2-diol
RHEA:21682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxophytanate + H2O2 => (2S)-2-hydroxyphytanate + O2
RHEA:53131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-carotene <=> epsilon-carotene
RHEA:34082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP
RHEA:59295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O <=> D-galactose + N-octadecanoylsphing-4-enine
REACT:R-HSA-3697920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLOCK acetylates lysine-10 of histone H3, H4 (Homo sapiens)
REACT:R-SCE-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
REACT:R-GGA-1433418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Gallus gallus)
RHEA:15148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose <=> alpha,alpha-trehalose
REACT:R-BTA-434989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA7A binds to PLXNC1 (Bos taurus)
RHEA:67931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O <=> a 3'-end 3'-phosphouridine-RNA + H(+)
GO:0015411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type taurine transporter transporter activity
GO:0015411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurine-transporting ATPase activity
GO:0015411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled taurine transporter activity
GO:0015411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent taurine transporter activity
GO:0015411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine ABC transporter
REACT:R-MMU-9733964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Mus musculus)
RHEA:22887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + glycine
RHEA:29879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-arginine(out) = ADP + H(+) + L-arginine(in) + phosphate
REACT:R-GGA-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Gallus gallus)
REACT:R-HSA-163568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)
RHEA:31044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonate semialdehyde + H2O + NAD(+) => 2 H(+) + methylmalonate + NADH
REACT:R-SCE-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Saccharomyces cerevisiae)
GO:0008670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity
GO:0008670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
GO:0008670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-enoyl-CoA reductase (NADPH2)
GO:0008670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-enoyl-CoA reductase (NADPH) activity
GO:0008670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-enoyl-CoA reductase activity
GO:0008670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dienoyl-CoA reductase (NADPH) activity
RHEA:68425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 => (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
REACT:R-DDI-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Dictyostelium discoideum)
REACT:R-SSC-6786245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNS1 transforms ATP, L-His, b-Ala to CARN (Sus scrofa)
RHEA:55853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA
REACT:R-PFA-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Plasmodium falciparum)
REACT:R-HSA-9718020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PTGFR agonists (Homo sapiens)
GO:0033094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	YgjG
GO:0033094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butane-1,4-diamine:2-oxoglutarate aminotransferase activity
GO:0033094	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	putrescine transaminase activity
GO:0033094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine:2-oxoglutarate aminotransferase activity
GO:0033094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine-alpha-ketoglutarate transaminase activity
GO:0033094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAT activity
GO:0033094	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	putrescine aminotransferase activity
GO:0033094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine:alpha-ketoglutarate aminotransferase activity
REACT:R-SCE-1482696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)
RHEA:47634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-arginine + NAD(+)
RHEA:21438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[translation elongation factor 2]-phosphate + ADP + H(+) => [translation elongation factor 2] + ATP
RHEA:64806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine => acetyl-CoA + S-(2-aminoethyl)-L-cysteine
REACT:R-HSA-8865425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds CBFB (Homo sapiens)
RHEA:50105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoyl-taurine
REACT:R-RNO-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Rattus norvegicus)
RHEA:72352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + glycocholate(out) => glutarate(out) + glycocholate(in)
REACT:R-CFA-982810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation (Canis familiaris)
REACT:R-GGA-158747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Gallus gallus)
REACT:R-PFA-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Plasmodium falciparum)
REACT:R-RNO-1855171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Rattus norvegicus)
REACT:R-MMU-917744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA loaded synaptic vesicle Docking and Priming (Mus musculus)
RHEA:52977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]
REACT:R-MMU-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Mus musculus)
RHEA:55190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate => 5-methyluridine(54) in tRNA + ATP + hydrogen sulfide
GO:0005078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP-kinase scaffold activity
GO:0005078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP-kinase scaffold protein activity
RHEA:38920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphing-4-enine-phosphocholine => choline + H(+) + sphing-4-enine 1-phosphate
REACT:R-HSA-8936851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHRR binds ARNT (Homo sapiens)
GO:1990932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5.8S rRNA binding
REACT:R-SCE-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Saccharomyces cerevisiae)
REACT:R-SCE-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Saccharomyces cerevisiae)
GO:0046569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLOX
GO:0046569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal oxidase activity
RHEA:34789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxosteroid + H(+) + NADPH => a 3beta-hydroxysteroid + NADP(+)
REACT:R-CEL-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Caenorhabditis elegans)
RHEA:57765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dinitrotoluene + NADH + O2 => 3-methyl-4-nitrocatechol + NAD(+) + nitrite
GO:0015191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine transmembrane transporter activity
GO:0015191	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-methionine transporter activity
RHEA:61576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) = (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH
REACT:R-HSA-8855648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM3 binds LAR-RPTP (Homo sapiens)
RHEA:45214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein] => acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+)
REACT:R-SPO-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Schizosaccharomyces pombe)
REACT:R-MMU-5607741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p52:RELB translocates from cytosol to nucleus (Mus musculus)
GO:0120152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent outer dynein arm binding
RHEA:34412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabigerolate + O2 => cannabidiolate + H2O2
REACT:R-HSA-9020282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Homo sapiens)
REACT:R-HSA-211991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)
REACT:R-SSC-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Sus scrofa)
REACT:R-CFA-9660192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR agonists bind VDR (Canis familiaris)
RHEA:40876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) => (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2
REACT:R-HSA-446187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG11 transfers the fourth and fifth Man to the N-glycan precursor (Homo sapiens)
REACT:R-HSA-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)
REACT:R-XTR-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Xenopus tropicalis)
REACT:R-BTA-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Bos taurus)
REACT:R-CFA-211882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A7 can 6beta-hydroxylate testosterone (Canis familiaris)
REACT:R-SCE-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
REACT:R-MMU-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Mus musculus)
REACT:R-HSA-9664855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Homo sapiens)
GO:0032396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inhibitory MHC class I receptor activity
REACT:R-SPO-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Schizosaccharomyces pombe)
REACT:R-XTR-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Xenopus tropicalis)
RHEA:68472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate
GO:0034827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity
REACT:R-SCE-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Saccharomyces cerevisiae)
RHEA:15283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3beta-ol => lathosterol
REACT:R-BTA-9680865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4, CYP2B6 bind ritonavir (Bos taurus)
RHEA:60079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 <=> 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)
REACT:R-RNO-8852317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GTSE1 (Rattus norvegicus)
REACT:R-DME-549241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-RNO-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Rattus norvegicus)
REACT:R-MMU-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Mus musculus)
RHEA:12792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alditol + NADP(+) <=> an aldose + H(+) + NADPH
RHEA:39180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-eicosenoyl-CoA + H(+) + NADPH => eicosanoyl-CoA + NADP(+)
REACT:R-HSA-202714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD58 binds CD2 (Homo sapiens)
RHEA:66982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoate + CoA + H(+) => 2-methylbutanoyl-CoA + H2O
RHEA:63552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin-(1-7) + H2O = angiotensin-(1-5) + L-histidyl-L-proline
REACT:R-SSC-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Sus scrofa)
REACT:R-CFA-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Canis familiaris)
REACT:R-SSC-5694421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6 dephosphorylates SEC24 (Sus scrofa)
REACT:R-RNO-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Rattus norvegicus)
REACT:R-CFA-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Canis familiaris)
GO:0015232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	haem transporter activity
GO:0015232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme transmembrane transporter activity
GO:0015232	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	heme transporter activity
REACT:R-MMU-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)
REACT:R-HSA-5662660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopachrome is transformed to DHICA by DCT (Homo sapiens)
RHEA:40986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)
REACT:R-CEL-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)
REACT:R-HSA-2731078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 2, (4) bind TGFB1 (Homo sapiens)
REACT:R-BTA-9027275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Bos taurus)
REACT:R-DDI-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Dictyostelium discoideum)
RHEA:18356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + K(+)(out) + Na(+)(in) <=> ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate
GO:0106286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate-CoA ligase activity
GO:0106286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate
RHEA:17688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + uracil 5-carboxylate <=> CO2 + uracil
REACT:R-GGA-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Gallus gallus)
REACT:R-CEL-389986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Caenorhabditis elegans)
GO:0003839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)
GO:0003839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-glutamyl-amino acid cyclotransferase activity
GO:0003839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamic cyclase activity
GO:0003839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamylcyclotransferase activity
GO:0003839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-glutamylcyclotransferase activity
RHEA:16639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine
RHEA:70782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + NADP(+) <=> 6-dehydro-D-glucose + H(+) + NADPH
REACT:R-MMU-1655879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiosulfate can transfer its sulfur atom to glutathione (Mus musculus)
RHEA:22428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopenicillin-N synthase"
RHEA:22428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N
RHEA:22428	skos:prefLabel	"isopenicillin-N synthase"
REACT:R-CFA-379044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gs-activating GPCR acts as a GEF for Gs (Canis familiaris)
REACT:R-GGA-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Gallus gallus)
RHEA:62102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O
GO:0080042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-glucose pyrophosphohydrolase activity
REACT:R-DDI-1482571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Dictyostelium discoideum)
REACT:R-CFA-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Canis familiaris)
RHEA:56176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O = 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)
RHEA:69082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + 2 H(+) + NADH => 3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+)
RHEA:42190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + H(+) + NADH => 3beta-hydroxy-5alpha-androstan-17-one + NAD(+)
REACT:R-RNO-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Rattus norvegicus)
REACT:R-SSC-75079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC C complex (Sus scrofa)
RHEA:34044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + neamine => 5''-phosphoribostamycin + diphosphate
RHEA:36915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA
RHEA:12204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + methylamine + reduced [electron-transfer flavoprotein] => dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein]
REACT:R-XTR-964800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuromedin-U receptors bind neuromedins U, S (Xenopus tropicalis)
REACT:R-XTR-417820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 receptor can bind to LPA (Xenopus tropicalis)
EC:6.1.2.-	skos:prefLabel	"Acid--alcohol ligases (ester synthases)"
EC:6.1.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acid--alcohol ligases (ester synthases)"
RHEA:27565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-nonaprenyl diphosphate + 7 diphosphate => (2E)-geranyl diphosphate + 7 isopentenyl diphosphate
RHEA:36649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine => 2-hydroxyhexadecanoyl-CoA + sphinganine
RHEA:58659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine
RHEA:25509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (1S,5S)-sabinene + diphosphate
RHEA:22908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP + H(+) + H2O = 3',5'-cyclic IMP + NH4(+)
RHEA:22908	skos:altLabel	"cyclic adenylate deaminase"
RHEA:22908	skos:prefLabel	"cAMP deaminase"
RHEA:22908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cAMP deaminase"
REACT:R-DME-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Drosophila melanogaster)
RHEA:25014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-tryptophan => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O
REACT:R-SSC-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)
REACT:R-GGA-211207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fragments of DFF45 dissociate from  DFF40 (Gallus gallus)
RHEA:67518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine
REACT:R-MMU-9656891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1SW binds 11cRAL (Mus musculus)
REACT:R-HSA-373745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK1 homophillic interaction (Homo sapiens)
REACT:R-DRE-9681763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1 binds IL1R1 inhibitors (Danio rerio)
REACT:R-DRE-8986083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates ROBO1 (Danio rerio)
RHEA:18562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH
RHEA:40522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-RNO-975147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Rattus norvegicus)
REACT:R-BTA-9611721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1-agonists bind ADRB1 (Bos taurus)
GO:0050209	skos:prefLabel	"polyvinyl-alcohol oxidase"
GO:0050209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polyvinyl-alcohol oxidase"
GO:0050209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a polyvinyl alcohol + n O2 = an oxidized polyvinyl alcohol + n H2O2
GO:0050209	skos:altLabel	"PVA oxidase"
GO:0050209	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyvinyl-alcohol:oxygen oxidoreductase activity
GO:0050209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyvinyl-alcohol oxidase activity
GO:0050209	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PVA oxidase activity
GO:0050209	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, polyvinyl alcohol
REACT:R-XTR-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Xenopus tropicalis)
RHEA:68290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-heptanoyl-L-seryl-[protein] => heptanoyl-CoA + L-seryl-[protein]
GO:0047883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine oxidase activity
GO:0047883	skos:prefLabel	"ethanolamine oxidase"
GO:0047883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethanolamine oxidase"
GO:0047883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethanolamine:oxygen oxidoreductase (deaminating)
GO:0047883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine + H2O + O2 = glycolaldehyde + H2O2 + NH4(+)
REACT:R-DRE-264976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Danio rerio)
REACT:R-BTA-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Bos taurus)
RHEA:20841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-histidine => CO2 + histamine
RHEA:22212	skos:prefLabel	"tartrate epimerase"
RHEA:22212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tartrate epimerase"
RHEA:22212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate = (2R,3S)-tartrate
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome oxidase activity
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome aa3 activity
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome-c oxidase activity
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cbb3-type cytochrome c oxidase
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	complex IV (mitochondrial electron transport) activity
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	indophenol oxidase
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	indophenolase
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ba3-type cytochrome c oxidase
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome a3 activity
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Warburg's respiratory enzyme activity
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	caa3-type cytochrome c oxidase
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aa3-type cytochrome c oxidase
GO:0004129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome c oxidase activity
REACT:R-XTR-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Xenopus tropicalis)
GO:0097162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADS box domain binding
REACT:R-SSC-416358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) inhibits PI3K alpha (Sus scrofa)
REACT:R-DDI-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
RHEA:50041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
RHEA:28778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dinoflagellate luciferin + O2 <=> H(+) + H2O + hnu + oxidized dinoflagellate luciferin
REACT:R-CFA-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Canis familiaris)
RHEA:30496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]
RHEA:17101	skos:prefLabel	"acylcarnitine hydrolase"
RHEA:17101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acylcarnitine hydrolase"
RHEA:17101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-acyl-(R)-carnitine = (R)-carnitine + a fatty acid + H(+)
REACT:R-SSC-8956676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TP73 (Sus scrofa)
REACT:R-DME-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Drosophila melanogaster)
GO:0052835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1D-myo-inositol-3,4,6-trisphosphate 1-phosphotransferase activity
GO:0052835	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	IP3 1-kinase activity
GO:0052835	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol-trisphosphate 1-kinase activity
GO:0052835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ins(3,4,6)P3 1-kinase activity
GO:0052835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 3,4,6-trisphosphate 1-kinase activity
GO:0052835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-3,4,6-trisphosphate 1-kinase activity
GO:0052835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)
GO:0052835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ins(3,4,6)P(3) 1-kinase activity
GO:0052835	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1D-myo-inositol-trisphosphate 1-kinase activity
REACT:R-SPO-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)
RHEA:31877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	marneral => (S)-2,3-epoxysqualene
REACT:R-CEL-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Caenorhabditis elegans)
REACT:R-HSA-174238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)
REACT:R-PFA-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)
REACT:R-RNO-9647660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds PIPs (Rattus norvegicus)
RHEA:14142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + glutathione disulfide + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + 2 glutathione
REACT:R-MMU-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Mus musculus)
REACT:R-HSA-4088299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXM1 stimulates CCNB2 transcription (Homo sapiens)
REACT:R-RNO-76496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Rattus norvegicus)
RHEA:65117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + aculene B + O2 => aculene A + CO2 + H2O + succinate
RHEA:42038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxolithocholate + H(+) + NADH => chenodeoxycholate + NAD(+)
GO:0042014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-19 receptor activity
GO:0042014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-19R
GO:0042014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-19 receptor activity
REACT:R-GGA-5687360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLL or POLM extends aligned DNA DSB ends to fill gaps (Gallus gallus)
REACT:R-DME-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Drosophila melanogaster)
REACT:R-MMU-5654614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)
RHEA:12404	skos:prefLabel	"lactose synthase"
RHEA:12404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactose synthase"
RHEA:12404	skos:altLabel	"UDP-galactose--glucose galactosyltransferase"
RHEA:12404	skos:altLabel	"N-acetyllactosamine synthase"
RHEA:12404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + UDP-alpha-D-galactose = H(+) + lactose + UDP
REACT:R-CEL-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Caenorhabditis elegans)
REACT:R-DME-3640872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP34 deubiquitinates AXIN1,AXIN2 (Drosophila melanogaster)
REACT:R-SSC-1234159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)
RHEA:71302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-isoleucine(out) + 2 Na(+)(out) <=> chloride(in) + L-isoleucine(in) + 2 Na(+)(in)
GO:0102781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isofucosterol hydroxylase activity
RHEA:32381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH => (1R,2R,4S)-limonene-1,2-diol + NAD(+)
RHEA:29028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + L-glutamate(in) => 2 H(+)(out) + L-glutamate(out)
REACT:R-XTR-75126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Xenopus tropicalis)
REACT:R-GGA-5665748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds RHOC:GTP (Gallus gallus)
RHEA:61221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)
REACT:R-MMU-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Mus musculus)
REACT:R-RNO-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)
REACT:R-BTA-2130336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial proteolyis of Ii by aspartic proteases to lip22 (Bos taurus)
REACT:R-MMU-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Mus musculus)
RHEA:31645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + mycinamicin III + S-adenosyl-L-homocysteine => mycinamicin VI + S-adenosyl-L-methionine
RHEA:37557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kanosamine + phosphate => D-kanosamine 6-phosphate + H2O
RHEA:18529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol + NAD(+) = 3-methylbutanal + H(+) + NADH
RHEA:35900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
RHEA:54615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylbutanoyl-CoA + O2 <=> 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate
RHEA:46360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylcholine 12-monooxygenase"
RHEA:46360	skos:altLabel	"oleate Delta(12)-hydroxylase"
RHEA:46360	skos:altLabel	"ricinoleic acid synthase"
RHEA:46360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:46360	skos:prefLabel	"phosphatidylcholine 12-monooxygenase"
RHEA:27589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + pyruvate <=> indole-3-pyruvate + L-alanine
REACT:R-CFA-508247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
RHEA:68838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R,7S)-himachala-9,11-diene + diphosphate => (2Z,6E)-farnesyl diphosphate
RHEA:44730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O
GO:0140473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear envelope-telomere anchor activity
GO:0140473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomere-nuclear envelope anchor activity
GO:0140473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomere-nuclear envelope anchoring activity
GO:0004883	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glucocorticoid receptor activity
GO:0004883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear glucocorticoid receptor activity
RHEA:67820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:37735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-XTR-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Xenopus tropicalis)
REACT:R-SSC-417825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y11 receptor can bind to ATP (Sus scrofa)
RHEA:40731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + 2 H2O = (20S)-protopanaxadiol + 2 D-glucose
RHEA:45139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O
REACT:R-DDI-4551683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOPORS with SUMO1 (Dictyostelium discoideum)
RHEA:21953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-pregnane-3,20-dione + NADP(+) => H(+) + NADPH + progesterone
RHEA:30620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + all-trans-zeta-carotene => 2 AH2 + all-trans-lycopene
REACT:R-GGA-4719424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO1. (Gallus gallus)
RHEA:33576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphophytoceramide + beta-D-mannose => a mannosylinositol-1-phosphophytoceramide + H2O
REACT:R-RNO-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Rattus norvegicus)
REACT:R-SSC-5358599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Sus scrofa)
REACT:R-MMU-8953115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds to MGA:MAX (Mus musculus)
RHEA:56172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + O2 = 8-demethyl-8-formylriboflavin 5'-phosphate + H2O
REACT:R-GGA-2730861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Gallus gallus)
REACT:R-RNO-1169192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B dephosphorylates GHR (Rattus norvegicus)
REACT:R-BTA-1604722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP9 by proteases (Bos taurus)
RHEA:17074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + cortisol => CoA + cortisol 21-acetate
RHEA:69358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-L-tyrosyl-[protein] + H2O => H(+) + hypobromite + L-tyrosyl-[protein]
RHEA:45003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 3-hydroxybutanoyl-CoA <=> CoA + O-3-hydroxybutanoyl-(R)-carnitine
RHEA:71808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + NAD(+) => an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide
RHEA:12837	skos:prefLabel	"choline kinase"
RHEA:12837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choline kinase"
RHEA:12837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + choline = ADP + H(+) + phosphocholine
REACT:R-RNO-6806647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Rattus norvegicus)
REACT:R-RNO-8878581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYRP1 oxidises DHICA to IQCA (Rattus norvegicus)
REACT:R-RNO-9757706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Rattus norvegicus)
REACT:R-DRE-6786166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translesion synthesis across unhooked ICL by POLN (Danio rerio)
REACT:R-CFA-5668629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Canis familiaris)
RHEA:10613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:17230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA
GO:0008712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADPglyceromanno-heptose 6-epimerase activity
GO:0008712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-L-glycero-D-manno-heptose 6-epimerase activity
GO:0008712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-glyceromanno-heptose 6-epimerase activity
REACT:R-CFA-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Canis familiaris)
REACT:R-RNO-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Rattus norvegicus)
REACT:R-DRE-5661115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Danio rerio)
REACT:R-RNO-8854905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)
REACT:R-DME-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Drosophila melanogaster)
REACT:R-CFA-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Canis familiaris)
REACT:R-XTR-5683405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP5C dephosphorylates TP53BP1 (Xenopus tropicalis)
GO:0102849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity
RHEA:43758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18]
REACT:R-RNO-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Rattus norvegicus)
RHEA:42683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hercynine + 2 L-selenocysteine + O2 <=> 2 H2O + 2 hercynylselenocysteine
RHEA:51655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH
RHEA:22282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + puromycin + S-adenosyl-L-homocysteine => O-demethylpuromycin + S-adenosyl-L-methionine
REACT:R-GGA-8952903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRHL2 hydrolyses poly(ADP-ribose) (Gallus gallus)
RHEA:56990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-5218905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Rattus norvegicus)
REACT:R-SSC-909718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of p-STAT1 homodimer (Sus scrofa)
REACT:R-HSA-9684017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)
REACT:R-DDI-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Dictyostelium discoideum)
RHEA:34947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-aminoacrylate + H(+) + H2O = 3-oxopropanoate + NH4(+)
RHEA:48614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]
REACT:R-XTR-3364026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SET1 complex trimethylates H3K4 at the MYC gene (Xenopus tropicalis)
REACT:R-MMU-199219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Mus musculus)
RHEA:14375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-DRE-8849157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Danio rerio)
REACT:R-RNO-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Rattus norvegicus)
RHEA:54074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-thujene + diphosphate => (2E)-geranyl diphosphate
RHEA:72525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine => 1,6-dihydroxyphenazine + S-adenosyl-L-methionine
REACT:R-DRE-9698170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Danio rerio)
REACT:R-RNO-1237081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Rattus norvegicus)
REACT:R-CFA-9710254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME oligomerizes (Canis familiaris)
REACT:R-DRE-211948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 can N-demethylate loperamide (Danio rerio)
RHEA:55011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)
REACT:R-XTR-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Xenopus tropicalis)
RHEA:19615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-homocysteine + trimethylsulfonium => dimethyl sulfide + S-adenosyl-L-methionine
RHEA:47976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O
REACT:R-RNO-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Rattus norvegicus)
REACT:R-RNO-9610152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Rattus norvegicus)
REACT:R-HSA-9731262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp6 localizes to the nuclear envelope (Homo sapiens)
RHEA:62153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + dTTP => dGDP + dTDP
GO:0045295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-catenin binding
GO:0045295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plakoglobin binding
REACT:R-BTA-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Bos taurus)
RHEA:44892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose = an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP
RHEA:10426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + glycine => H2O + N-benzoylglycine
REACT:R-XTR-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Xenopus tropicalis)
REACT:R-HSA-8938770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Homo sapiens)
RHEA:37845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA
GO:0018633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide monooxygenase activity
GO:0018633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulphide monooxygenase activity
REACT:R-HSA-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Homo sapiens)
REACT:R-MMU-398040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma activation of PLC beta (Mus musculus)
REACT:R-CEL-6787540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUK phosphorylates beta-Fuc to Fuc1P (Caenorhabditis elegans)
RHEA:20891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpropanoyl-CoA + H2O <=> 3-hydroxy-2-methylpropanoate + CoA + H(+)
RHEA:14124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
GO:0016166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoene dehydrogenase activity
REACT:R-RNO-9663492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL dissociates from GSTA1, FABP1 (Rattus norvegicus)
RHEA:44074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + ATP
REACT:R-HSA-9686710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of S protein into S1:S2 (Homo sapiens)
RHEA:63666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH
RHEA:29456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(in) => D-serine(out)
RHEA:33909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + formaldehyde + H2O2 => 4-(methylamino)butanoate + H2O + O2
REACT:R-CEL-8848596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds PXN (Caenorhabditis elegans)
RHEA:25970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzil + H(+) + NADPH => (S)-benzoin + NADP(+)
REACT:R-XTR-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Xenopus tropicalis)
REACT:R-HSA-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Homo sapiens)
RHEA:17337	skos:altLabel	"cato2ase"
RHEA:17337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"catechol 2,3-dioxygenase"
RHEA:17337	skos:altLabel	"2,3-pyrocatechase"
RHEA:17337	skos:altLabel	"metapyrocatechase"
RHEA:17337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + O2 = (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)
RHEA:17337	skos:prefLabel	"catechol 2,3-dioxygenase"
RHEA:67539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine
REACT:R-HSA-5683879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA genes produce SFTPA proteins (Homo sapiens)
RHEA:57050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase] => AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]
REACT:R-MMU-1980233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Mus musculus)
REACT:R-SSC-375140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds promyogenic cadherins (Sus scrofa)
RHEA:48956	skos:altLabel	"iodinase"
RHEA:48956	skos:altLabel	"TPO"
RHEA:48956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O
RHEA:48956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"iodide peroxidase"
RHEA:48956	skos:altLabel	"thyroperoxidase"
RHEA:48956	skos:altLabel	"thyroid peroxidase"
RHEA:48956	skos:prefLabel	"iodide peroxidase"
REACT:R-RNO-193965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 18HCORST to ALDO (Rattus norvegicus)
REACT:R-HSA-8941613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-SCE-3781024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Saccharomyces cerevisiae)
REACT:R-CEL-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Caenorhabditis elegans)
REACT:R-SSC-372819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Sus scrofa)
RHEA:49607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH
REACT:R-DME-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Drosophila melanogaster)
RHEA:29186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + 2 O2 <=> 2 H(+) + menaquinone-8 + 2 superoxide
REACT:R-SSC-5250947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH complex binds rDNA promoter (Sus scrofa)
REACT:R-BTA-6799191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Bos taurus)
REACT:R-RNO-6809325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)
REACT:R-MMU-2672334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNN channels transport extracellular Na+ to cytosol (Mus musculus)
RHEA:68823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate
RHEA:32773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dioxo-6-phenylhexa-3-enoate => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
RHEA:60144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate
RHEA:56623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O <=> 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)
REACT:R-SSC-5686301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 binds SFTPAs (Sus scrofa)
RHEA:38673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate(out) => sphinganine 1-phosphate(in)
REACT:R-HSA-9007514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds APAF1 gene promoter (Homo sapiens)
REACT:R-SPO-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Schizosaccharomyces pombe)
GO:0004917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-7 receptor activity
GO:0004917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-7 receptor activity
GO:0004917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-7R
REACT:R-XTR-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Xenopus tropicalis)
REACT:R-HSA-209754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photolytic cleavage and thermal isomerization of 7-dehydroCHOL (Homo sapiens)
REACT:R-SSC-6807578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface in the phagosome (Sus scrofa)
RHEA:57557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1
RHEA:23627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in tRNA + NADP(+) <=> a uridine in tRNA + H(+) + NADPH
REACT:R-BTA-446694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 phosphorylates IRAK1 (Bos taurus)
RHEA:61476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingoid base N-stearoyltransferase"
RHEA:61476	skos:altLabel	"mammalian ceramide synthase 1"
RHEA:61476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)
RHEA:61476	skos:prefLabel	"sphingoid base N-stearoyltransferase"
REACT:R-HSA-9769419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds RET gene enhancer (Homo sapiens)
REACT:R-DRE-9700154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds SHC1 (Danio rerio)
RHEA:30126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecanoyl-[ACP] <=> H(+) + holo-[ACP] + tetradecanoate
REACT:R-SPO-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Schizosaccharomyces pombe)
REACT:R-CFA-9756162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)
GO:0008692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybutanoyl-CoA 3-epimerase activity
GO:0008692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutyryl-CoA epimerase activity
GO:0008692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyacyl-CoA epimerase activity
GO:0008692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybutyryl coenzyme A epimerase activity
GO:0019875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-aminohexanoic acid oligomer hydrolase activity
GO:0019875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-aminohexanoate-dimer hydrolase activity
GO:0019875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity
REACT:R-RNO-5654646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)
REACT:R-GGA-9748983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)
REACT:R-SSC-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Sus scrofa)
REACT:R-BTA-388863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Bos taurus)
REACT:R-CEL-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Caenorhabditis elegans)
RHEA:26262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopimara-7,15-dienal + NADP(+) => 2 H(+) + isopimarate + NADPH
RHEA:33202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + NAD(+) <=> butanal + H(+) + NADH
RHEA:72700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylate + H(+) + NADH => NAD(+) + propanoate
RHEA:50091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + S-adenosyl-L-methionine <=> an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine
RHEA:12510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loganin + S-adenosyl-L-homocysteine => loganate + S-adenosyl-L-methionine
RHEA:45419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O <=> 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)
RHEA:66849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Cu(2+) + NADH => 2 Cu(+) + H(+) + NAD(+)
REACT:R-BTA-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
REACT:R-CFA-448963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of MyoD:E protein with MEF2 (Canis familiaris)
REACT:R-HSA-210872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-phosphorylation of Tie2 (Homo sapiens)
RHEA:59132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"staphyloferrin B synthase"
RHEA:59132	skos:prefLabel	"staphyloferrin B synthase"
RHEA:59132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP = AMP + diphosphate + H(+) + staphyloferrin B
RHEA:70099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + o-quinone methide + peniphenone D = penilactone A
RHEA:32241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene => gamma-carotene
REACT:R-GGA-190388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3c (Gallus gallus)
RHEA:57810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2
REACT:R-RNO-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Rattus norvegicus)
REACT:R-MMU-8867754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
RHEA:66438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + pent-1-en-3-one => NADP(+) + pentan-3-one
REACT:R-RNO-9026408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Rattus norvegicus)
RHEA:36608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginine + O2 => (2S,3S)-hydroxyarginine + CO2 + succinate
RHEA:63944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + sphinga-4E,14Z-dienine = an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)
REACT:R-HSA-6787540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUK phosphorylates beta-Fuc to Fuc1P (Homo sapiens)
REACT:R-RNO-5610733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Rattus norvegicus)
REACT:R-MMU-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Mus musculus)
RHEA:57865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Bos taurus)
GO:0034814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxy benzo(a)pyrene dioxygenase activity
RHEA:50328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Bos taurus)
REACT:R-DRE-451347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JNK by DSCAM (Danio rerio)
RHEA:28281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine + H2O <=> H(+) + L-alanine + sulfite
RHEA:20742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-tartrate => H2O + trans-2,3-epoxysuccinate
REACT:R-SPO-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Schizosaccharomyces pombe)
REACT:R-GGA-174587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Gallus gallus)
RHEA:46252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46252	skos:altLabel	"acyl-lipid 4-desaturase"
RHEA:46252	skos:prefLabel	"acyl-lipid (7-3)-desaturase"
RHEA:46252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid (7-3)-desaturase"
RHEA:53388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP
REACT:R-HSA-2247513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1:ligand is endocytosed (Homo sapiens)
REACT:R-CFA-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Canis familiaris)
REACT:R-CFA-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Canis familiaris)
RHEA:61654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein]
RHEA:62293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2
RHEA:19785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dihydroclavaminate + O2 = clavaminate + CO2 + H2O + succinate
REACT:R-RNO-9634702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Rattus norvegicus)
REACT:R-RNO-8854466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds RELN (Rattus norvegicus)
REACT:R-MMU-9014295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GAPs stimulate RAC2 GTPase activity (Mus musculus)
REACT:R-HSA-9679045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR9 dimer binds HCQ (Homo sapiens)
REACT:R-DRE-5687758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP4C:PPP4R2 dephosphorylates RPA2 (Danio rerio)
REACT:R-SCE-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Saccharomyces cerevisiae)
REACT:R-CFA-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Canis familiaris)
RHEA:55398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine => (R)-carnitine + H(+) + NADH + O2
REACT:R-GGA-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Gallus gallus)
RHEA:71000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:50826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2
REACT:R-DME-8854897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Drosophila melanogaster)
REACT:R-DME-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)
RHEA:17215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-mannosamine => UDP-N-acetyl-alpha-D-glucosamine
RHEA:32437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2
RHEA:33958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIBOA + UDP-alpha-D-glucose <=> DIBOA beta-D-glucoside + H(+) + UDP
REACT:R-XTR-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Xenopus tropicalis)
EC:3.4.14.12	skos:altLabel	"prolyltripeptidyl aminopeptidase"
EC:3.4.14.12	skos:altLabel	"PTP-A"
EC:3.4.14.12	skos:altLabel	"prolyltripeptidyl amino peptidase"
EC:3.4.14.12	skos:prefLabel	"Xaa-Xaa-Pro tripeptidyl-peptidase"
EC:3.4.14.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Xaa-Xaa-Pro tripeptidyl-peptidase"
EC:3.4.14.12	skos:altLabel	"prolyl tripeptidyl peptidase"
EC:3.4.14.12	skos:altLabel	"TPP"
REACT:R-SSC-8986995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Sus scrofa)
REACT:R-HSA-191654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-src associates with Cx43 in gap junctions (Homo sapiens)
RHEA:41925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H2O
REACT:R-DRE-5654594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)
RHEA:16203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + H(+) + pyruvate => 4-amino-4-deoxychorismate
REACT:R-HSA-1912398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 binds DNER (Homo sapiens)
REACT:R-SSC-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Sus scrofa)
REACT:R-DRE-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Danio rerio)
RHEA:42404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lactose 6-phosphate = beta-D-glucose + D-galactose 6-phosphate
RHEA:18755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + H(+) + NADPH => [protein]-dithiol + NADP(+)
RHEA:55401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) => archaeosine(15) in tRNA
REACT:R-CFA-164620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Canis familiaris)
REACT:R-XTR-446868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Interleukin 1 receptor complex binds Tollip (Xenopus tropicalis)
RHEA:51494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-198440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Mus musculus)
REACT:R-MMU-9732527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds rosiglitazone (Mus musculus)
REACT:R-HSA-9032426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2 phosphorylates FRS3 (Homo sapiens)
RHEA:27604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate => (2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate
RHEA:16482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 S-adenosyl-L-methionine => 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine
RHEA:30942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dIDP <=> ADP + dITP
RHEA:38436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
RHEA:24074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
REACT:R-DRE-1980233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Danio rerio)
RHEA:21652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chlorobenzoate + H(+) + NADH + O2 = catechol + chloride + CO2 + NAD(+)
RHEA:38412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)
REACT:R-HSA-9749320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
REACT:R-RNO-8848355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes retinyl palmitate (Rattus norvegicus)
RHEA:62430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA
REACT:R-CFA-5263614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeOH is reduced to MeSeH by TXNRD1 (Canis familiaris)
RHEA:28620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylbutanenitrile + H2O + NADP(+) => 2-methylbutyronitrile + H(+) + NADPH + O2
REACT:R-DDI-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Dictyostelium discoideum)
REACT:R-DME-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Drosophila melanogaster)
RHEA:43896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0034001	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinase activity
GO:0034001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin sulfate ABC exolyase activity
GO:0034001	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinase ABC activity
GO:0034001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin sulfate ABC exoeliminase activity
GO:0034001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin-sulfate-ABC exolyase activity
GO:0034001	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitin sulfate ABC lyase activity
GO:0034001	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ChS ABC lyase activity
GO:0034001	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitin ABC eliminase activity
GO:0034001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ChS ABC lyase II activity
GO:0018702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity
GO:0018702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDE dehalogenase activity
GO:0018702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity
REACT:R-CFA-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Canis familiaris)
RHEA:34111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine
REACT:R-DRE-4084980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Danio rerio)
RHEA:32016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-delta-cadinene + diphosphate
REACT:R-SPO-203613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylation of eNOS (Schizosaccharomyces pombe)
RHEA:68695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) <=> 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
RHEA:32531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = alpha-D-mannose 1-phosphate + D-glucose
RHEA:32531	skos:prefLabel	"4-O-beta-D-mannosyl-D-glucose phosphorylase"
RHEA:32531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-O-beta-D-mannosyl-D-glucose phosphorylase"
RHEA:32531	skos:altLabel	"mannosylglucose phosphorylase"
REACT:R-DME-2065549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Drosophila melanogaster)
REACT:R-DRE-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Danio rerio)
RHEA:15991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH => (R)-mevalonate + CoA + 2 NADP(+)
REACT:R-SCE-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Saccharomyces cerevisiae)
REACT:R-HSA-6809793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR2 binds SBF2 (Homo sapiens)
GO:0008117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphingosine-1-phosphate aldolase activity
GO:0008117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphinganine-1-phosphate palmitaldehyde-lyase activity
GO:0008117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine-1-phosphate aldolase activity
GO:0008117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphinganine-1-phosphate alkanal-lyase activity
GO:0008117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphingosine-1-phosphate lyase activity
GO:0008117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrosphingosine 1-phosphate aldolase activity
GO:0008117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)
GO:0008117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphinganine-1-phosphate lyase activity
REACT:R-DRE-708349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD2 oligomerizes (Danio rerio)
REACT:R-MMU-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Mus musculus)
RHEA:56257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP
REACT:R-BTA-9025995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Bos taurus)
REACT:R-XTR-2559456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)
RHEA:47532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NAD(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
RHEA:35341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosanoyl-CoA + H(+) + NADPH => 3-hydroxyicosanoyl-CoA + NADP(+)
REACT:R-MMU-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)
REACT:R-CFA-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Canis familiaris)
REACT:R-XTR-159046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Xenopus tropicalis)
RHEA:62771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
RHEA:52897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin => 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate
RHEA:48117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-XTR-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Xenopus tropicalis)
REACT:R-GGA-264679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serum albumin binds 2-lysophosphatidylcholine (Gallus gallus)
REACT:R-DRE-216076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Danio rerio)
RHEA:61214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + myricetin 3-O-beta-D-glucoside + UDP => myricetin + UDP-alpha-D-glucose
REACT:R-DME-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Drosophila melanogaster)
RHEA:42786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine => adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine
REACT:R-HSA-109343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Homo sapiens)
REACT:R-HSA-9637635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esxA binds B2M (Homo sapiens)
REACT:R-HSA-1251992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of P-ERBB4jmA isoforms by ADAM17 (Homo sapiens)
REACT:R-DRE-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)
RHEA:56555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]
REACT:R-BTA-1299359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TALK (Bos taurus)
REACT:R-GGA-5675206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEA15 binds MAPK monomers and dimers (Gallus gallus)
RHEA:20984	skos:prefLabel	"sphingomyelin phosphodiesterase D"
RHEA:20984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingomyelin phosphodiesterase D"
RHEA:20984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin + H2O = an N-acylsphing-4-enine 1-phosphate + choline + H(+)
RHEA:34433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-lariciresinol + H(+) + NADPH => (+)-secoisolariciresinol + NADP(+)
RHEA:47216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-202203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PI3K to plasma membrane (Mus musculus)
RHEA:22749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-4-methyl-2-oxoglutarate => 2 pyruvate
RHEA:27721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP <=> inosine + phosphate
REACT:R-SSC-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Sus scrofa)
RHEA:52267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(aminomethyl)indole + 2 S-adenosyl-L-methionine <=> gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-BTA-9020259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Bos taurus)
REACT:R-CFA-9667619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B,2 bind atosiban (Canis familiaris)
RHEA:55362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol => 11-cis-retinol
REACT:R-DDI-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Dictyostelium discoideum)
RHEA:21729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + H2O + 2 NAD(+) => GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH
REACT:R-HSA-9729318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 phosphorylates nucleoprotein (Homo sapiens)
REACT:R-RNO-182594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of INK4 family proteins with CDK4/6 (Rattus norvegicus)
REACT:R-GGA-443402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Gallus gallus)
GO:0102687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity
RHEA:68869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + benzoate + H(+) + NADPH => AMP + benzaldehyde + diphosphate + NADP(+)
RHEA:41924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O
REACT:R-SSC-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Sus scrofa)
REACT:R-HSA-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Homo sapiens)
REACT:R-HSA-9612444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STMN1 gene (Homo sapiens)
REACT:R-BTA-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Bos taurus)
REACT:R-SCE-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)
RHEA:65492	skos:prefLabel	"[mycofactocin precursor peptide]-tyrosine decarboxylase"
RHEA:65492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[mycofactocin precursor peptide]-tyrosine decarboxylase"
RHEA:65492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine
RHEA:40514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfopropanediol + NAD(+) <=> (2S)-3-sulfolactaldehyde + H(+) + NADH
REACT:R-BTA-2467798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTTG1 (Securin) sequesters ESPL1 (Separase) (Bos taurus)
REACT:R-CFA-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Canis familiaris)
REACT:R-DME-2161195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Drosophila melanogaster)
REACT:R-GGA-981535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) binds C3bBb, C4bC2a (Gallus gallus)
REACT:R-HSA-9012349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)
REACT:R-CFA-6807055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR7 reduces 7-dehydroCHOL to CHOL (Canis familiaris)
RHEA:70838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-glutamine(out) + Na(+)(out) <=> L-arginine(out) + L-glutamine(in) + Na(+)(in)
REACT:R-MMU-9005995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the SIN3A co-repressor complex (Mus musculus)
REACT:R-BTA-1013013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of GABA B receptor with G protein beta-gamma subunits (Bos taurus)
RHEA:70900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)
REACT:R-HSA-5362500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
REACT:R-MMU-2213239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MHC II alpha beta heterodimer (Mus musculus)
RHEA:47191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol <=> hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]
REACT:R-HSA-5675433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP5 dephosphorylates RAF1 S338 (Homo sapiens)
REACT:R-GGA-909738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 bind the common beta chain (Gallus gallus)
REACT:R-CEL-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Caenorhabditis elegans)
REACT:R-CFA-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Canis familiaris)
RHEA:72879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-(2-amino-1-hydroxyethyl)phosphonate = NH4(+) + phosphonoacetaldehyde
REACT:R-GGA-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Gallus gallus)
REACT:R-GGA-5623519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP and RAB8A bind to the ciliary targeting complex (Gallus gallus)
RHEA:61933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-miconazole(in) + ATP + H2O => (S)-miconazole(out) + ADP + H(+) + phosphate
REACT:R-CEL-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)
RHEA:62183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + peregrinol diphosphate <=> diphosphate + viteagnusin D
RHEA:36311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + H2O + NAD(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADH
REACT:R-GGA-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Gallus gallus)
REACT:R-MMU-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Mus musculus)
REACT:R-MMU-169895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk's SH3 domain engages C3G (Mus musculus)
REACT:R-RNO-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Rattus norvegicus)
REACT:R-HSA-139909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BMF to mitochondria (Homo sapiens)
REACT:R-GGA-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Gallus gallus)
RHEA:61672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-cysteine = diphosphate + L-cysteinyl-5'-AMP
RHEA:26067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hygromycin B <=> 4-O-phosphohygromycin B + ADP + H(+)
RHEA:32936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin + H2O => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)
RHEA:23546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose
RHEA:22053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + NH4(+) => AH2 + H(+) + hydroxylamine
REACT:R-XTR-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Xenopus tropicalis)
REACT:R-MMU-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Mus musculus)
REACT:R-RNO-8944220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIII (Rattus norvegicus)
REACT:R-HSA-9694452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein E forms a homopentamer (Homo sapiens)
REACT:R-GGA-6785361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of FANCD2:FANCI (Gallus gallus)
REACT:R-MMU-5661120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Mus musculus)
RHEA:36050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-glyceraldehyde + H2O <=> (R)-glycerate + AH2 + H(+)
RHEA:58390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-3-all-trans-hexaprenylbenzoate + diphosphate => 4-aminobenzoate + all-trans-hexaprenyl diphosphate
REACT:R-SPO-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Schizosaccharomyces pombe)
REACT:R-DME-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)
REACT:R-DME-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Drosophila melanogaster)
REACT:R-RNO-8852019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET bound PI3K generates PIP3 (Rattus norvegicus)
RHEA:23680	skos:altLabel	"nucleoside triphosphate hydrolase"
RHEA:23680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside-triphosphate phosphatase"
RHEA:23680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate
RHEA:23680	skos:altLabel	"NTPase"
RHEA:23680	skos:prefLabel	"nucleoside-triphosphate phosphatase"
RHEA:23680	skos:altLabel	"nucleoside 5-triphosphatase"
RHEA:23680	skos:altLabel	"nucleoside triphosphate phosphohydrolase"
RHEA:23680	skos:altLabel	"nucleoside-triphosphatase"
RHEA:23680	skos:altLabel	"nucleoside-5-triphosphate phosphohydrolase"
RHEA:61829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stigmasterol + UDP-alpha-D-glucose => H(+) + stigmasteryl 3-beta-D-glucoside + UDP
RHEA:10592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:11945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)
GO:1902301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactarate transmembrane transporter activity
GO:1902301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate transmembrane transporter activity
GO:1902301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactaric acid anion transmembrane transporter activity
RHEA:35627	skos:altLabel	"3'GT"
RHEA:35627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP
RHEA:35627	skos:prefLabel	"delphinidin 3,5-di-O-glucoside 3'-O-glucosyltransferase"
RHEA:35627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"delphinidin 3,5-di-O-glucoside 3'-O-glucosyltransferase"
RHEA:35627	skos:altLabel	"UDP-glucose:anthocyanin 3'-O-glucosyltransferase"
REACT:R-CEL-216064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha8beta1 with Tenascin-C (Caenorhabditis elegans)
REACT:R-DME-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)
REACT:R-XTR-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)
RHEA:24208	skos:prefLabel	"1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)"
RHEA:24208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)"
RHEA:24208	skos:altLabel	"AFR"
RHEA:24208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH
RHEA:24208	skos:altLabel	"1,5-anhydro-D-fructose reductase"
REACT:R-RNO-442273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)
REACT:R-HSA-446221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mannose-1-phosphate converted to GDP-Mannose (Homo sapiens)
REACT:R-HSA-6801641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the PLK2 gene (Homo sapiens)
REACT:R-HSA-9757434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylsalicylic acid dissolves (Homo sapiens)
REACT:R-RNO-2064417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-1 (TJP1) (Rattus norvegicus)
REACT:R-SSC-9706330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS6 (Sus scrofa)
REACT:R-DRE-1234159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome proteolyzes ub-HIF-alpha (Danio rerio)
REACT:R-XTR-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Xenopus tropicalis)
REACT:R-DME-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Drosophila melanogaster)
REACT:R-BTA-3000137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Bos taurus)
REACT:R-GGA-9699579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of FLT3  (Gallus gallus)
RHEA:17479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine => precorrin-6B + 2 S-adenosyl-L-methionine
REACT:R-XTR-74718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalisation of the insulin receptor (Xenopus tropicalis)
RHEA:43388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate
REACT:R-GGA-2187355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters phosphorylated SMAD2/3 (Gallus gallus)
RHEA:51163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Drosophila melanogaster)
GO:0038064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	collagen receptor activity
GO:0038064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane collagen receptor activity
REACT:R-SCE-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Saccharomyces cerevisiae)
RHEA:32645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2 Fe(III)-[cytochrome c] + H2O + lupanine
RHEA:52348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:70165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + methotrexate(out) => H(+)(in) + methotrexate(in)
RHEA:27989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyacetone + NADP(+) <=> H(+) + methylglyoxal + NADPH
GO:0031686	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A1 adenosine receptor ligand
GO:0031686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 adenosine receptor binding
REACT:R-CFA-9029551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Canis familiaris)
GO:0050051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene-B4 omega-hydroxylase activity
GO:0050051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene-B4 20-hydroxylase activity
GO:0050051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTB4 20-hydroxylase activity
GO:0050051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTB(4) 20-hydroxylase activity
GO:0050051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTB(4) omega-hydroxylase activity
GO:0050051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene-B4 20-monooxygenase activity
GO:0050051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTB4 omega-hydroxylase activity
REACT:R-DRE-429767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Danio rerio)
REACT:R-BTA-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Bos taurus)
REACT:R-DRE-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Danio rerio)
RHEA:23486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + D-cellobiono-1,5-lactone => A + D-cellobiose
GO:0005330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine transmembrane transporter activity
GO:0005330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine:sodium symporter activity
GO:0005330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/dopamine symporter activity
GO:0005330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine:sodium:chloride symporter activity
REACT:R-MMU-420127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGRP receptor can bind calcitonin gene-related peptides (Mus musculus)
REACT:R-DRE-9627104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP3 (Danio rerio)
REACT:R-DRE-1678708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(2) (Danio rerio)
REACT:R-RNO-5607744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 binds BCL10 (Rattus norvegicus)
REACT:R-DRE-1855205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)
REACT:R-RNO-4551738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO2,3 (Rattus norvegicus)
REACT:R-HSA-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
RHEA:38951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)
GO:0080044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 7-O-glucosyltransferase activity
RHEA:33977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + DIMBOA => DIMBOA beta-D-glucoside + H2O
REACT:R-BTA-77321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Bos taurus)
REACT:R-CEL-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Caenorhabditis elegans)
REACT:R-CEL-2172666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds condensin II (Caenorhabditis elegans)
REACT:R-SPO-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Schizosaccharomyces pombe)
GO:0046972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H4-K16 specific)
GO:0046972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K16 acetyltransferase activity
GO:0046972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine acetyltransferase activity (H4-K16 specific)
GO:0046972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H4-K16 specific)
GO:0043022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ribosome receptor activity
GO:0043022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosome binding
REACT:R-CFA-216064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha8beta1 with Tenascin-C (Canis familiaris)
REACT:R-XTR-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Xenopus tropicalis)
RHEA:26526	skos:altLabel	"ECH2"
RHEA:26526	skos:prefLabel	"enoyl-CoA hydratase 2"
RHEA:26526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enoyl-CoA hydratase 2"
RHEA:26526	skos:altLabel	"D-3-hydroxyacyl-CoA hydro-lyase"
RHEA:26526	skos:altLabel	"2-enoyl-CoA hydratase 2"
RHEA:26526	skos:altLabel	"D-specific 2-trans-enoyl-CoA hydratase"
RHEA:26526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O
RHEA:36585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => dTDP-alpha-D-fucose + NADP(+)
RHEA:59220	skos:altLabel	"2-hydroxy-5-methylmuconate semialdehyde hydrolase"
RHEA:59220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)
RHEA:59220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-6-oxohepta-2,4-dienoate hydrolase"
RHEA:59220	skos:prefLabel	"2-hydroxy-6-oxohepta-2,4-dienoate hydrolase"
RHEA:24815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-valine
RHEA:43981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + NADPH + O2 => 15-hydroxyhexadecanoate + H2O + NADP(+)
REACT:R-DRE-909720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN alpha/beta binds to IFNAR2 (Danio rerio)
REACT:R-HSA-4088207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Golgi lumen glycoconjugates translocate to the plasma membrane (Homo sapiens)
REACT:R-DME-9033527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Drosophila melanogaster)
RHEA:69960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Sus scrofa)
REACT:R-GGA-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Gallus gallus)
RHEA:34193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O
REACT:R-DRE-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Danio rerio)
RHEA:46490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in)
REACT:R-RNO-191422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate-5-phosphate is further phosphorylated. (Rattus norvegicus)
REACT:R-RNO-9023633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)
REACT:R-BTA-6791218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Bos taurus)
RHEA:62262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(in) + Mn(2+)(in) => 2 hydrogencarbonate(out) + Mn(2+)(out)
RHEA:11682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + GMP + 2 H(+) + L-glutamate => ATP + H2O + L-glutamine + XMP
RHEA:49638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + pyruvate => H2O + methylglyoxal + O2
RHEA:72754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ochratoxin A <=> L-phenylalanine + ochratoxin alpha
REACT:R-GGA-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Gallus gallus)
REACT:R-SCE-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Saccharomyces cerevisiae)
REACT:R-DRE-2060328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS1 (Danio rerio)
REACT:R-HSA-2025724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Homo sapiens)
RHEA:59554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => N,N',N'',N'''-tetraacetylchitotetraose + O2
RHEA:14743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylene-L-glutamate + NH4(+) => 4-methylene-L-glutamine + H2O
REACT:R-SSC-5607751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes (Sus scrofa)
REACT:R-BTA-9006850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor JAK phosphorylation (Bos taurus)
REACT:R-HSA-3928608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIMK phosphorylates CFL1, inactivating it (Homo sapiens)
REACT:R-SSC-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Sus scrofa)
RHEA:54230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine
REACT:R-SSC-8985594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYO9B inactivates RHOA (Sus scrofa)
REACT:R-RNO-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Rattus norvegicus)
REACT:R-HSA-9691204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR8 dimer binds TLR7, TLR8 ligands (Homo sapiens)
REACT:R-CEL-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Caenorhabditis elegans)
REACT:R-CFA-352029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Canis familiaris)
RHEA:18436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexylamine + H2O + O2 <=> cyclohexanone + H2O2 + NH4(+)
REACT:R-CFA-1250353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)
REACT:R-BTA-5687465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds RBBP8 (Bos taurus)
REACT:R-SSC-210290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHIP (Sus scrofa)
REACT:R-CEL-6781899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds SIAH2 (Caenorhabditis elegans)
REACT:R-HSA-373727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds CD2AP (Homo sapiens)
REACT:R-GGA-6786048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Gallus gallus)
RHEA:71996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + preaspterpenacid acid I
GO:0061483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfinylpropanyl adenylate synthase
GO:0061483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SPA synthase
GO:0034952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate semialdehyde decarboxylase activity
REACT:R-HSA-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Homo sapiens)
REACT:R-SSC-9605644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Sus scrofa)
REACT:R-SSC-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Sus scrofa)
RHEA:72959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) = (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)
RHEA:13268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine <=> 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine
GO:0047659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity
GO:0047659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-santonin 1,2-reductase activity
GO:0047659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-santonin 1,2-reductase activity
REACT:R-CFA-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)
RHEA:56385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
RHEA:63672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH = H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)
RHEA:11774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+)
REACT:R-MMU-1433454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GAB2 by SFKs (Mus musculus)
REACT:R-GGA-8937613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHBP binds CRH (Gallus gallus)
RHEA:25969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-benzoin + NADP(+) => benzil + H(+) + NADPH
REACT:R-DME-8865265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds MYC and KDM5B (Drosophila melanogaster)
REACT:R-RNO-8934742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRMT1 (Rattus norvegicus)
RHEA:14925	skos:prefLabel	"mannose-6-phosphate 6-reductase"
RHEA:14925	skos:altLabel	"NADPH-dependent M6P reductase"
RHEA:14925	skos:altLabel	"NADPH-mannose-6-P reductase"
RHEA:14925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + H(+) + NADPH
RHEA:14925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannose-6-phosphate 6-reductase"
RHEA:62556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + H(+) = 4-methylcatechol + CO2
RHEA:54562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP
REACT:R-XTR-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Xenopus tropicalis)
RHEA:48054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan
REACT:R-RNO-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Rattus norvegicus)
REACT:R-RNO-3928595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ARP2/3 and G-actin (Rattus norvegicus)
REACT:R-HSA-6809565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9 (Homo sapiens)
REACT:R-HSA-9694441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3CLp cleaves pp1a (Homo sapiens)
REACT:R-DRE-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Danio rerio)
RHEA:38349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate => (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
REACT:R-DRE-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Danio rerio)
REACT:R-SSC-8874745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Sus scrofa)
REACT:R-XTR-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Xenopus tropicalis)
REACT:R-SCE-3000449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Saccharomyces cerevisiae)
RHEA:67976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-neurosporene = beta-zeacarotene
REACT:R-CFA-4088130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds FOXM1 (Canis familiaris)
REACT:R-GGA-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Gallus gallus)
RHEA:60955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-5-hydroxyferulate + S-adenosyl-L-methionine <=> (E)-sinapate + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-74707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IRS to insulin receptor (Gallus gallus)
REACT:R-CEL-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Caenorhabditis elegans)
RHEA:57396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine = 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine
RHEA:57396	skos:prefLabel	"3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase"
RHEA:57396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase"
REACT:R-HSA-9026927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT hydrolyses RCTR1 to RCTR2 (Homo sapiens)
REACT:R-BTA-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Bos taurus)
GO:0051033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exportin complex translocates pre-miRNA to cytosol (Homo sapiens)
GO:0051033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA transmembrane transporter activity
REACT:R-CEL-977348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHGDH tetramer dehydrogenates 3PG (Caenorhabditis elegans)
REACT:R-SSC-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)
RHEA:57392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine = 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)
RHEA:56183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2
RHEA:47062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:64770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol => S-3-(hexan-1-ol)-L-cysteine
REACT:R-BTA-9725206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds FCERI (Bos taurus)
REACT:R-CFA-192061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP46A1 24-hydroxylates CHOL (Canis familiaris)
RHEA:31643	skos:prefLabel	"mycinamicin VI 2''-O-methyltransferase"
RHEA:31643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycinamicin VI + S-adenosyl-L-methionine = H(+) + mycinamicin III + S-adenosyl-L-homocysteine
RHEA:31643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycinamicin VI 2''-O-methyltransferase"
REACT:R-SSC-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Sus scrofa)
EC:3.12.1.-	skos:prefLabel	"Acting on sulfur-sulfur bonds"
EC:3.12.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on sulfur-sulfur bonds"
RHEA:50321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Danio rerio)
REACT:R-XTR-420586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Necl-2 trans heterodimer interaction (Xenopus tropicalis)
RHEA:31785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + tuberculosinol => H2O + tuberculosinyl diphosphate
REACT:R-CFA-2466085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from R* to release atRAL (Canis familiaris)
RHEA:22390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine => acetyl-CoA + N(6)-hydroxy-L-lysine
RHEA:25458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + gamma-humulene => (2E,6E)-farnesyl diphosphate
REACT:R-BTA-6814094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds ARFIP2 (Bos taurus)
RHEA:48113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
GO:0050508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity
GO:0050508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity
GO:0050508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0050508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-acetylglucosaminyltransferase II activity
GO:0050508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
REACT:R-HSA-2162099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP (Homo sapiens)
RHEA:16638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine => [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP
RHEA:66535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]
RHEA:67500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine
REACT:R-DDI-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)
RHEA:39556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)
REACT:R-DME-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Drosophila melanogaster)
RHEA:71675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-leucine(out) + H(+)(out) = glycyl-L-leucine(in) + H(+)(in)
REACT:R-BTA-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Bos taurus)
RHEA:57373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH => (6S)-NADPHX
REACT:R-BTA-5665998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 binds SRF (Bos taurus)
RHEA:27510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)
RHEA:60766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinerin II + CoA => (1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone
RHEA:61526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2
RHEA:66366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methyl-3,7-dioxodecanedioyl-CoA => (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O
REACT:R-DME-1234159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
RHEA:37935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
REACT:R-DRE-9021627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
RHEA:41856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+)
REACT:R-SSC-9757686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDL (Sus scrofa)
RHEA:34736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + sphinganine => an N-acylsphinganine + CoA + H(+)
RHEA:38796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-RNO-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)
RHEA:67112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:17202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-arabinonate => 2,5-dioxopentanoate + H2O
GO:0080011	skos:prefLabel	"baruol synthase"
GO:0080011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"baruol synthase"
GO:0080011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = baruol
GO:0080011	skos:altLabel	"BARS1"
GO:0080011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baruol synthase activity
REACT:R-SSC-3780994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Sus scrofa)
REACT:R-RNO-3209159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERF translocates to the cytosol (Rattus norvegicus)
RHEA:37795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(P)H oxidase (H2O-forming)"
RHEA:37795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADPH + O2 = 2 H2O + 2 NADP(+)
RHEA:37795	skos:prefLabel	"NAD(P)H oxidase (H2O-forming)"
RHEA:61346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + H2O2 + NH4(+) => H2O + L-serine + O2
REACT:R-SPO-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Schizosaccharomyces pombe)
REACT:R-MMU-9033533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)
RHEA:58748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethylnectriapyrone + S-adenosyl-L-methionine = H(+) + nectriapyrone + S-adenosyl-L-homocysteine
RHEA:57248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP = dGTP + glycolate + H(+)
REACT:R-SSC-8850997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 binds PTEN (Sus scrofa)
RHEA:72544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) => 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)
RHEA:12331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n) + phosphate <=> [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate
RHEA:33185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) => citrate(in)
REACT:R-DRE-9756180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)
REACT:R-SSC-140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS1 (Sus scrofa)
REACT:R-HSA-5684267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
REACT:R-HSA-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Homo sapiens)
REACT:R-SPO-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Schizosaccharomyces pombe)
REACT:R-XTR-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Xenopus tropicalis)
RHEA:18359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + tropinone => NADP(+) + tropine
RHEA:61374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O
REACT:R-CFA-5654603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS3 (Canis familiaris)
REACT:R-PFA-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Plasmodium falciparum)
REACT:R-RNO-9670673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIX is secreted (Rattus norvegicus)
REACT:R-MMU-211950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 24-hydroxylates CTL (Mus musculus)
REACT:R-DME-2024084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS-GAGs translocate to the lysosome for degradation (Drosophila melanogaster)
REACT:R-HSA-201637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plectin-1 (Homo sapiens)
RHEA:28828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(out) + putrescine(in) => L-ornithine(in) + putrescine(out)
RHEA:51186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octadecanoate + sn-glycero-3-phospho-L-serine => 1-octadecanoyl-sn-glycero-3-phosphoserine + H2O
RHEA:10232	skos:altLabel	"dioxotetrahydropyrimidine-ribonucleotide diphosphorylase"
RHEA:10232	skos:prefLabel	"dioxotetrahydropyrimidine phosphoribosyltransferase"
RHEA:10232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine 5'-monophosphate + diphosphate = 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate
RHEA:10232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dioxotetrahydropyrimidine phosphoribosyltransferase"
RHEA:10232	skos:altLabel	"dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase"
RHEA:55565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxytryptamine + ATP => 4-hydoxytryptamine 4-phosphate + ADP + H(+)
RHEA:35117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-coumaroyl)acetyl-CoA + CO2 + CoA => 4-coumaroyl-CoA + H(+) + malonyl-CoA
REACT:R-HSA-190388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3c (Homo sapiens)
RHEA:57134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-octopamine + H2O + L-dehydroascorbate => L-ascorbate + O2 + tyramine
REACT:R-DRE-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
RHEA:17030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin + H2O => allantoate + H(+)
RHEA:16739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => H(+) + NADH + O2 + toluene
RHEA:48902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-GGA-9701003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 heterodimer (Gallus gallus)
RHEA:56656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH
GO:0035599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic acid methylthiotransferase activity
REACT:R-DRE-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Danio rerio)
REACT:R-MMU-2559568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Mus musculus)
RHEA:24135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose <=> UDP-alpha-D-galactofuranose
GO:0052832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol monophosphate 3-phosphatase activity
REACT:R-DRE-3000074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN2 binds RCbl in the circulation (Danio rerio)
RHEA:44237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:14696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP
RHEA:43351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z-octadecenoate)(in) <=> cholesteryl (9Z-octadecenoate)(out)
RHEA:51190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxynitrite => nitric oxide + superoxide
REACT:R-SSC-5684806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates CLEC1B dimer:PDPN (Sus scrofa)
REACT:R-DME-5654684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR4 (Drosophila melanogaster)
REACT:R-CFA-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
REACT:R-DDI-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Dictyostelium discoideum)
RHEA:14343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxoadipate + CO2 => 2-oxoglutarate + glyoxylate + H(+)
REACT:R-CFA-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Canis familiaris)
REACT:R-HSA-2467811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of sister chromatids (Homo sapiens)
RHEA:53386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH => 5,10-methylenetetrahydromethanopterin + NAD(+)
REACT:R-CEL-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)
REACT:R-BTA-5623643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH13 reduces atRAL to atROL (Bos taurus)
REACT:R-HSA-194308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Homo sapiens)
REACT:R-BTA-8942101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 monoubiquitinates Histone H2B (Bos taurus)
RHEA:53100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-1912359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HES1 binds TLE (Homo sapiens)
RHEA:46784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-6788974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) (Homo sapiens)
REACT:R-CFA-8944219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVI (Canis familiaris)
REACT:R-DRE-449058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family are secreted (Danio rerio)
RHEA:33995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase"
RHEA:33995	skos:prefLabel	"gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase"
RHEA:33995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-butirosin B = 5-oxo-L-proline + butirosin B
REACT:R-DRE-5693108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Danio rerio)
REACT:R-RNO-198870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:57920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) = H(+) + L-asparaginyl-tRNA(Asn) + phosphate
RHEA:50864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
RHEA:43426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP
GO:0018648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methanesulfonate monooxygenase (NADH)"
GO:0018648	skos:altLabel	"MSAMO"
GO:0018648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MSA monooxygenase activity
GO:0018648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methanesulfonic acid monooxygenase activity
GO:0018648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mesylate monooxygenase activity
GO:0018648	skos:prefLabel	"methanesulfonate monooxygenase (NADH)"
GO:0018648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MSAMO activity
GO:0018648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanesulfonate monooxygenase activity
GO:0018648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanesulfonate,NADH:oxygen oxidoreductase activity
GO:0018648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanesulphonic acid monooxygenase activity
GO:0018648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methanesulfonate,FMNH2:oxygen oxidoreductase activity
GO:0018648	skos:altLabel	"mesylate monooxygenase"
GO:0018648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanesulfonate + NADH + O2 = formaldehyde + H2O + NAD(+) + sulfite
GO:0018648	skos:altLabel	"methanesulfonic acid monooxygenase"
GO:0018648	skos:altLabel	"MSA monooxygenase"
REACT:R-MMU-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Mus musculus)
REACT:R-HSA-5205820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)
REACT:R-MMU-141159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-mediated dimerization of procaspase-8 (Mus musculus)
REACT:R-DRE-5668718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)
RHEA:14521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + NADP(+) = (2E)-geranial + H(+) + NADPH
RHEA:14521	skos:prefLabel	"geraniol dehydrogenase (NADP(+))"
RHEA:14521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geraniol dehydrogenase (NADP(+))"
RHEA:50444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3
RHEA:20847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + pyruvate <=> ADP + H(+) + oxaloacetate + phosphate
REACT:R-RNO-192331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)
RHEA:10041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H2O => AMP + phosphate
RHEA:53246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:36980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA
RHEA:41153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+) => 1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O
REACT:R-BTA-73596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => dUMP + NH4+ (Bos taurus)
REACT:R-CFA-1980233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Canis familiaris)
REACT:R-CEL-9009308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 polyubiquitinates RUNX2 (Caenorhabditis elegans)
REACT:R-MMU-1475017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Mus musculus)
RHEA:32213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (Z)-5-oxohex-2-enedioate
REACT:R-DDI-8950724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Dictyostelium discoideum)
RHEA:24643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosteryl 3-beta-D-glucoside + H2O <=> D-glucose + ergosterol
REACT:R-SPO-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Schizosaccharomyces pombe)
REACT:R-MMU-1564169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VIII degradation by MMP1 (Mus musculus)
REACT:R-DRE-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Danio rerio)
RHEA:44126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + tetradecanyl hexadecanoate => hexadecanoyl-CoA + tetradecan-1-ol
RHEA:72323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + thiosulfate(out) = 3 Na(+)(in) + thiosulfate(in)
RHEA:46950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(7)-methyl-GTP + S-adenosyl-L-homocysteine => GTP + S-adenosyl-L-methionine
REACT:R-CFA-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Canis familiaris)
RHEA:55799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + phenol <=> H2O + hydroquinone + NAD(+)
RHEA:31198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH
REACT:R-CFA-194308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Canis familiaris)
REACT:R-DDI-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Dictyostelium discoideum)
GO:0090491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
RHEA:67602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+) + O(6)-methyl-dGMP => H2O + O(6)-methyl-dGTP
REACT:R-XTR-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Xenopus tropicalis)
RHEA:39455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)
REACT:R-DDI-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:43836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADPH + O2 = 26-hydroxycholesterol + H2O + NADP(+)
REACT:R-HSA-175258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-LTR formation due to circularization of viral DNA (Homo sapiens)
RHEA:65092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] = aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentalenene synthase activity
GO:0050467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pentalenene synthetase activity
GO:0050467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)
GO:0050467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)
REACT:R-RNO-8865482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KMT2A (MLL) binds RUNX1 (Rattus norvegicus)
RHEA:24910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L,L-cystathionine = 2-aminobut-2-enoate + L-cysteine
REACT:R-DDI-5651723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Dictyostelium discoideum)
RHEA:59842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5,6,7,8-tetrahydrofolate + syringate
RHEA:63736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + H(+) + NADPH = 2-phenylethanol + NADP(+)
REACT:R-XTR-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Xenopus tropicalis)
REACT:R-CEL-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Caenorhabditis elegans)
REACT:R-DME-4551768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO2,3 (Drosophila melanogaster)
GO:0008317	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gurken receptor ligand
GO:0008317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gurken receptor binding
RHEA:64523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA <=> A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde
RHEA:45182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine => 2 (E)-4-coumaroyl-CoA + spermidine
RHEA:59789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH
REACT:R-CFA-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Canis familiaris)
REACT:R-SSC-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Sus scrofa)
REACT:R-HSA-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Homo sapiens)
REACT:R-RNO-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Rattus norvegicus)
REACT:R-MMU-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Mus musculus)
REACT:R-DME-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Drosophila melanogaster)
GO:0015419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled sulfate transmembrane transporter activity
GO:0015419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulphate transporting ATPase activity
GO:0015419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfate-transporting ATPase activity
GO:0015419	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sulfate/thiosulfate porter activity
GO:0015419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfate transmembrane-transporting ATPase activity
GO:0015419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type sulfate transporter activity
GO:0015419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate ABC transporter
GO:0019786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Atg8-specific protease activity
GO:0019786	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APG8-PE hydrolase
GO:0019786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Atg8-specific peptidase activity
GO:0019786	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APG8-specific protease activity
RHEA:68968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mandelate + O2 = H2O2 + phenylglyoxylate
RHEA:22490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + glutathione => S-(hydroxymethyl)glutathione
REACT:R-CFA-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Canis familiaris)
REACT:R-HSA-2408500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSSeH condenses with GSH to form H2Se and GSSG (Homo sapiens)
REACT:R-BTA-193065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Bos taurus)
RHEA:66938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenanthramide C + CoA => (E)-caffeoyl-CoA + 5-hydroxyanthranilate
REACT:R-CFA-9015122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors bind Va:Xa (Canis familiaris)
REACT:R-CEL-9698844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds HSP90:CDC37 (Caenorhabditis elegans)
RHEA:29003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-homoserine(in) = H(+)(in) + L-homoserine(out)
RHEA:11300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sequoyitol dehydrogenase"
RHEA:11300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH
RHEA:11300	skos:prefLabel	"sequoyitol dehydrogenase"
RHEA:48657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-2,4-diaminobutanoate => (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)
REACT:R-DRE-8953037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F8 forms homodimers (Danio rerio)
REACT:R-HSA-8941623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
RHEA:59581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester
REACT:R-DME-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)
RHEA:34830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 <=> H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)
REACT:R-HSA-9620515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2B,EP300 acetylate FOXO3 under oxidative stress (Homo sapiens)
RHEA:67540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine
RHEA:40448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-pristanoyl-CoA => (2S)-pristanoyl-CoA
RHEA:65523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-9702354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCA antibodies (Rattus norvegicus)
REACT:R-MMU-159795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Mus musculus)
RHEA:45558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine => H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-PFA-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Plasmodium falciparum)
RHEA:11049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine => 1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid
REACT:R-BTA-8935732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds SIN3A,(SIN3B) co-repressor (Bos taurus)
RHEA:72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine + CO2 + H2O + NAD(+) => 6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2
REACT:R-MMU-76475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Mus musculus)
REACT:R-SSC-186778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 binds to the active receptor (Sus scrofa)
REACT:R-GGA-4093336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
REACT:R-CFA-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Canis familiaris)
RHEA:18339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + psi-UMP => D-ribose 5-phosphate + uracil
RHEA:63573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin-(1-8) => L-arginine + neurotensin-(1-7)
GO:0140412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc:bicarbonate symporter activity
RHEA:44554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O
EC:3.4.22.44	skos:prefLabel	"nuclear-inclusion-a endopeptidase"
EC:3.4.22.44	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nuclear-inclusion-a endopeptidase"
EC:3.4.22.44	skos:altLabel	"potyvirus NIa protease"
REACT:R-CFA-6810843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin binds periplakin (Canis familiaris)
REACT:R-RNO-372819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Rattus norvegicus)
RHEA:38338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb1 + 2 H2O <=> (20S)-ginsenoside Rg3 + 2 D-glucose
RHEA:39540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)
REACT:R-XTR-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Xenopus tropicalis)
RHEA:11461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glucose => AMP + D-glucose 6-phosphate + H(+)
GO:0017075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syntaxin-1 binding
REACT:R-SSC-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Sus scrofa)
RHEA:65028	skos:prefLabel	"(+)-pinoresinol hydroxylase"
RHEA:65028	skos:altLabel	"pinoresinol alpha-hydroxylase"
RHEA:65028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-pinoresinol hydroxylase"
RHEA:65028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-pinoresinol + H2O + 2 oxidized [azurin] = (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]
RHEA:50270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate
GO:0070674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hypoxanthine-NAD oxidoreductase activity
GO:0070674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hypoxanthine/NAD+ oxidoreductase activity
GO:0070674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hypoxanthine:NAD+ oxidoreductase activity
GO:0070674	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hypoxanthine oxidoreductase activity
GO:0070674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine dehydrogenase activity
GO:0070674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-hypoxanthine dehydrogenase activity
GO:0070674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hypoxanthine/NAD(+) oxidoreductase activity
REACT:R-HSA-8964280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Gq binds BTK (Homo sapiens)
REACT:R-BTA-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Bos taurus)
REACT:R-RNO-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)
RHEA:30804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + H2O + NADP(+) => 4-aminobutanoate + 2 H(+) + NADPH
RHEA:29613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + 2 nitric oxide => H2O + NADP(+) + nitrous oxide
REACT:R-CEL-4546386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO1 (Caenorhabditis elegans)
REACT:R-CFA-2029271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
REACT:R-DRE-427656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Danio rerio)
GO:0106100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-pinacene synthase activity
REACT:R-HSA-2187355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters phosphorylated SMAD2/3 (Homo sapiens)
RHEA:12377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-fuculose => ADP + H(+) + L-fuculose 1-phosphate
REACT:R-DRE-508513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B binds JAK3 (Danio rerio)
GO:0050212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	progesterone 11alpha-monooxygenase activity
GO:0050212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	progesterone 11-alpha-hydroxylase activity
GO:0050212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	progesterone 11a-monooxygenase activity
GO:0050212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)
GO:0050212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	progesterone 11-alpha-monooxygenase activity
GO:0050212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	progesterone 11alpha-hydroxylase activity
REACT:R-HSA-879909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of STAT5a/b by JAK2 (Homo sapiens)
REACT:R-BTA-450187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated within the TAK1 complex (Bos taurus)
REACT:R-RNO-1433488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHP2 by SFKs (Rattus norvegicus)
REACT:R-CFA-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Canis familiaris)
RHEA:45033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome c] + H2O + hydroxylamine => 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite
REACT:R-HSA-9755734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 N binds IKBKB (Homo sapiens)
RHEA:54808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 = H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)
RHEA:12882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + sn-glycerol 3-phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)
GO:0047780	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aconitate hydratase activity
GO:0047780	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	citrate hydro-lyase activity
GO:0047780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate dehydratase activity
GO:0047780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate hydro-lyase (cis-aconitate-forming)
GO:0047780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate hydro-lyase (cis-aconitate-forming) activity
REACT:R-CEL-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Caenorhabditis elegans)
REACT:R-CEL-77303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Caenorhabditis elegans)
REACT:R-XTR-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Xenopus tropicalis)
RHEA:23462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl alcohol + cetraxate + H(+) => benzyl cetraxate + H2O
RHEA:22588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal = 1-pyrroline + H2O
REACT:R-XTR-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Xenopus tropicalis)
REACT:R-HSA-446894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)
REACT:R-HSA-6786034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Homo sapiens)
RHEA:23017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) => (2R,3R)-dihydrokaempferol + H(+) + NADPH
REACT:R-XTR-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Xenopus tropicalis)
RHEA:22576	skos:altLabel	"N-acyl-homoserine lactone lactonase"
RHEA:22576	skos:altLabel	"acyl homoserine degrading enzyme"
RHEA:22576	skos:altLabel	"acyl-homoserine-lactone acylase"
RHEA:22576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quorum-quenching N-acyl-homoserine lactonase"
RHEA:22576	skos:altLabel	"N-acyl-L-homoserine lactone hydrolase"
RHEA:22576	skos:altLabel	"N-acyl homoserine lactone hydrolase"
RHEA:22576	skos:altLabel	"quorum-quenching lactonase"
RHEA:22576	skos:altLabel	"AHLase"
RHEA:22576	skos:altLabel	"N-acyl homoserine lactonase"
RHEA:22576	skos:altLabel	"AHL lactonase"
RHEA:22576	skos:altLabel	"AHL-inactivating enzyme"
RHEA:22576	skos:prefLabel	"quorum-quenching N-acyl-homoserine lactonase"
RHEA:22576	skos:altLabel	"quorum-quenching N-acyl homoserine lactone hydrolase"
RHEA:22576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+)
RHEA:22576	skos:altLabel	"AHL-degrading enzyme"
REACT:R-BTA-8874849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBRF binds CREB3 (Bos taurus)
REACT:R-HSA-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)
REACT:R-XTR-3899291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of EP300 with SUMO1 (Xenopus tropicalis)
RHEA:38719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + ATP + H2O = (R)-carnitine(in) + ADP + H(+) + phosphate
RHEA:18666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) => (2R)-3-phosphoglycerate + [phosphate](n+1)
RHEA:69968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) => Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)
RHEA:22204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)
REACT:R-HSA-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Homo sapiens)
REACT:R-SSC-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Sus scrofa)
RHEA:72736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) => UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)
RHEA:59678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraono-1,5-lactone + H2O2 => D-maltotetraose + O2
RHEA:14084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + indole
REACT:R-CEL-8877941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SMAD1 in the nucleus (Caenorhabditis elegans)
RHEA:72845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA(out) + ADP(in) => 3'-dephospho-CoA(in) + ADP(out)
REACT:R-SSC-5676592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xRANK binds RANKL,sRANKL trimer:RANK (Sus scrofa)
REACT:R-MMU-976991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor ligands bind the prolactin receptor (Mus musculus)
REACT:R-XTR-6803753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAAA hydrolyses NAEs to FAs and ethanolamine (Xenopus tropicalis)
RHEA:24975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:57423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 oxidized [cytochrome P450] <=> H(+) + NAD(+) + 2 reduced [cytochrome P450]
REACT:R-BTA-75886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Bos taurus)
REACT:R-HSA-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Homo sapiens)
REACT:R-CFA-6805792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S291-PHF20 translocates to cytosol (Canis familiaris)
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	multicopper ferroxidase iron transport mediator activity
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hephaestin
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferro:O2 oxidoreductase activity
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferroxidase I
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferroxidase, iron II:oxygen oxidoreductase activity
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iron(II): oxygen oxidoreductase activity
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferroxidase activity
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ceruloplasmin
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	HEPH
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	caeruloplasmin
GO:0004322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Fe(II):oxygen oxidoreductase activity
REACT:R-CEL-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Caenorhabditis elegans)
RHEA:61712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine
REACT:R-CFA-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Canis familiaris)
REACT:R-RNO-5218832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds PAK2 (Rattus norvegicus)
REACT:R-MMU-983194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-1 is a heterotetramer (Mus musculus)
REACT:R-XTR-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Xenopus tropicalis)
RHEA:59064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylluteothin + S-adenosyl-L-methionine = luteothin + S-adenosyl-L-homocysteine
GO:0050022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinose 1-dehydrogenase (NAD+) activity
GO:0050022	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-arabinose 1-dehydrogenase activity
GO:0050022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arabinose:NAD+ 1-oxidoreductase activity
REACT:R-HSA-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Homo sapiens)
REACT:R-GGA-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Gallus gallus)
RHEA:34810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:11729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopentanol + NAD(+) => cyclopentanone + H(+) + NADH
REACT:R-CFA-2534388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone Activation Of CatSper (Canis familiaris)
REACT:R-DME-9613570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Drosophila melanogaster)
REACT:R-CEL-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Caenorhabditis elegans)
REACT:R-HSA-9683734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylated M localizes to the Golgi membrane (Homo sapiens)
REACT:R-DME-9038029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxysterol binds ESR1, ESR2 (Drosophila melanogaster)
RHEA:13692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + glycerol <=> glycerol 1-phosphate + H(+) + phosphate
RHEA:63518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2',3,3'-tetraol + H2O + NAD(+) => biphenyl-2,2',3-triol + H(+) + NADH + O2
RHEA:39422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)
REACT:R-CEL-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)
REACT:R-DRE-2730902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of p-CARMA1 (Danio rerio)
RHEA:15163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + homogentisate + NAD(+) => 4-hydroxyphenylacetate + H(+) + NADH + O2
RHEA:68743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxocholesterol + H(+) + NADPH <=> 7alpha-hydroxycholesterol + NADP(+)
REACT:R-DME-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Drosophila melanogaster)
RHEA:11738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocineole + H(+) + NADH => 2-exo-hydroxy-1,8-cineole + NAD(+)
REACT:R-HSA-9616105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1 binds CDK5R1 gene (Homo sapiens)
REACT:R-BTA-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Bos taurus)
RHEA:14026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + sepiapterin => NH4(+) + xanthopterin-B2
GO:0050320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tartrate epimerase activity
GO:0050320	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tartaric racemase activity
EC:3.2.1.164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactan endo-1,6-beta-galactosidase"
EC:3.2.1.164	skos:altLabel	"endo-beta-(1->6)-galactanase"
EC:3.2.1.164	skos:prefLabel	"galactan endo-1,6-beta-galactosidase"
EC:3.2.1.164	skos:altLabel	"endo-1,6-beta-galactanase"
RHEA:31908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-norcoclaurine + S-adenosyl-L-methionine => (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine
RHEA:23783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate + propanoyl-CoA <=> (2S,3S)-2-methylcitrate + CoA + H(+)
REACT:R-CFA-1855153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Canis familiaris)
REACT:R-HSA-140825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Homo sapiens)
REACT:R-HSA-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Homo sapiens)
REACT:R-DME-9641089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin binds Ub:UBE2N:UBE2V1 (Drosophila melanogaster)
REACT:R-DME-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)
REACT:R-GGA-377643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
RHEA:23379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonate + NAD(+) <=> 3-dehydro-D-erythronate + H(+) + NADH
RHEA:72717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate => (R)-dihydrolipoate + ATP + H(+)
RHEA:31335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin cytosine dinucleotide
RHEA:31335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"molybdenum cofactor cytidylyltransferase"
RHEA:31335	skos:altLabel	"MoCo cytidylyltransferase"
RHEA:31335	skos:prefLabel	"molybdenum cofactor cytidylyltransferase"
RHEA:31335	skos:altLabel	"Mo-MPT cytidyltransferase"
GO:0008953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penicillin acylase activity
GO:0008953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	penicillin amidase activity
GO:0008953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzylpenicillin acylase activity
GO:0008953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity
GO:0008953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penicillin amidohydrolase activity
GO:0008953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	novozym 217
GO:0008953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-acylamino-beta-lactam acylhydrolase activity
GO:0008953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	semacylase activity
GO:0008953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ampicillin acylase activity
REACT:R-XTR-5229132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 binds APP (Xenopus tropicalis)
RHEA:10978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroquinoline-2,5,6-triol + NAD(+) => H(+) + NADH + O2 + quinolin-2-ol
RHEA:52981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]
REACT:R-DME-2022061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan sulfate can be further sulfated on position 2 of iduronate (Drosophila melanogaster)
EC:3.4.11.21	skos:prefLabel	"aspartyl aminopeptidase"
EC:3.4.11.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartyl aminopeptidase"
REACT:R-DRE-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)
RHEA:55797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + phenol => H2O + hydroquinone + NAD(+)
RHEA:59234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + hydropyrenol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O
RHEA:23383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP
REACT:R-MMU-8953418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 complex binds E2F6.com-1 core (Mus musculus)
REACT:R-MMU-164620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Mus musculus)
REACT:R-HSA-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Homo sapiens)
REACT:R-CEL-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)
RHEA:72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauro-beta-muricholate(out) => 2 Na(+)(in) + tauro-beta-muricholate(in)
RHEA:68592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O = (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate
RHEA:64461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate
REACT:R-XTR-9033949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Xenopus tropicalis)
REACT:R-CFA-3296244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUCNR1 binds SUCCA (Canis familiaris)
REACT:R-HSA-373738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin interacts with syntenin-1 (Homo sapiens)
REACT:R-BTA-5625959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Bos taurus)
REACT:R-GGA-352872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 6-phosphate <=> glucose 6-phosphate (Gallus gallus)
RHEA:45333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin + O2 => 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)
REACT:R-CFA-173626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1r (Canis familiaris)
REACT:R-SPO-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Schizosaccharomyces pombe)
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-prenyltransferase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	all-trans-nonaprenyl-diphosphate synthase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyprenylpyrophosphate synthetase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nonaprenyl pyrophosphate synthetase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	terpenoidallyltransferase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	solanesyl diphosphate synthetase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	SPP-synthase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	terpenyl pyrophosphate synthetase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	solanesyl pyrophosphate synthetase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	solanesyl-diphosphate synthase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	solPP synthase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	SPP synthase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-octaprenyltranstransferase activity
GO:0052923	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nonaprenyl diphosphate synthase activity
REACT:R-CFA-9603984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Canis familiaris)
RHEA:12475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-ethylglycine + O2 <=> ethylamine + glyoxylate + H2O2
RHEA:41069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-BTA-388468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR1A,B (Bos taurus)
REACT:R-SCE-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Saccharomyces cerevisiae)
RHEA:57056	skos:prefLabel	"D-apiose dehydrogenase"
RHEA:57056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apiofuranose + NAD(+) = D-apionolactone + H(+) + NADH
RHEA:57056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-apiose dehydrogenase"
RHEA:43798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:63607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Pyr1]apelin-13 + H2O <=> [Pyr1]apelin-12 + L-phenylalanine
REACT:R-MMU-5666129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
REACT:R-CFA-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Canis familiaris)
REACT:R-PFA-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Plasmodium falciparum)
RHEA:31167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + H(+) + NADH
REACT:R-PFA-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Plasmodium falciparum)
REACT:R-RNO-1168633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB translocates from the cytosol to the nucleus (Rattus norvegicus)
REACT:R-CFA-1614605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is dioxygenated (Canis familiaris)
RHEA:46533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-450054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-2 receptor alpha binds interleukin-2 (Homo sapiens)
REACT:R-BTA-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Bos taurus)
RHEA:17569	skos:altLabel	"1,2-dehydroreticulinium ion reductase"
RHEA:17569	skos:prefLabel	"1,2-dehydroreticulinium reductase (NADPH)"
RHEA:17569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH
RHEA:17569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,2-dehydroreticulinium reductase (NADPH)"
RHEA:43261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
RHEA:26060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine => methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)
REACT:R-HSA-5632670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 phosphorylates SMO dimer (Homo sapiens)
REACT:R-MMU-8956458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNLS:FAD oxidises dh-beta-NAD to NAD+ (Mus musculus)
REACT:R-BTA-8851842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUC20 binds MET and inhibits GRB2 binding (Bos taurus)
RHEA:46325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + A => 3-oxochola-4,17-dien-22-oyl-CoA + AH2
REACT:R-MMU-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Mus musculus)
RHEA:44535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-SSC-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Sus scrofa)
RHEA:37397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:55990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
GO:0008047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme activator activity
GO:0008047	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloenzyme activator activity
REACT:R-SSC-8950453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Sus scrofa)
REACT:R-DME-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Drosophila melanogaster)
REACT:R-SSC-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Sus scrofa)
REACT:R-XTR-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)
RHEA:41302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-sphing-4-enine <=> (9Z)-octadecenoate + sphing-4-enine
RHEA:11566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + D-gluconate => 4-O-beta-D-glucopyranosyl-D-gluconate + phosphate
RHEA:68279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + L-seryl-[protein] <=> CoA + O-butanoyl-L-seryl-[protein]
REACT:R-BTA-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Bos taurus)
REACT:R-DRE-4420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 disassociates from VEGFR2 and translocate to PM (Danio rerio)
REACT:R-CFA-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Canis familiaris)
GO:0018770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity
RHEA:67908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary linear alkyl sulfate ester + H2O = a primary alcohol + H(+) + sulfate
RHEA:67908	skos:prefLabel	"linear primary-alkylsulfatase"
RHEA:67908	skos:altLabel	"type III linear primary-alkylsulfatase"
RHEA:67908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linear primary-alkylsulfatase"
REACT:R-CEL-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Caenorhabditis elegans)
RHEA:70055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cremeomycin = 2-hydroxy-4-methoxybenzoate + A + N2
REACT:R-XTR-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Xenopus tropicalis)
RHEA:29332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + 2 H(+)(in) => fumarate(out) + 2 H(+)(out)
REACT:R-MMU-3134946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 ubiquitination by TRIM21 (Mus musculus)
RHEA:19481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA
RHEA:19481	skos:prefLabel	"3-oxoadipyl-CoA thiolase"
RHEA:19481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxoadipyl-CoA thiolase"
RHEA:19481	skos:altLabel	"beta-ketoadipyl-CoA thiolase"
REACT:R-HSA-4720473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALG3 does not add mannose to the N-glycan precursor (Homo sapiens)
RHEA:34804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => bisdemethoxycurcumin + 2 CO2 + 3 CoA
RHEA:46223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,17beta-diol + NAD(+) <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH
REACT:R-XTR-379387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DA to form 3MT (Xenopus tropicalis)
RHEA:68594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O
REACT:R-CEL-399712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)
RHEA:68988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:12914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate + ATP + H(+) => (R)-lipoyl-5'-AMP + diphosphate
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside triphosphate phosphohydrolase activity
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleoside triphosphate hydrolase activity
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside triphosphates (Homo sapiens)
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside-5-triphosphate phosphohydrolase activity
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleoside triphosphate phosphatase activity
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleoside triphosphate phosphatase activity
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	apyrase activity
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPase activity
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleoside-triphosphatase activity
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleoside triphosphatase activity
GO:0017111	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleoside 5-triphosphatase activity
RHEA:45826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + ethanolamine => H(+) + L-serine
RHEA:42198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-CFA-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Canis familiaris)
RHEA:70834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-leucine(out) + Na(+)(out) <=> L-arginine(out) + L-leucine(in) + Na(+)(in)
REACT:R-SSC-8938887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML binds RUNX1 (Sus scrofa)
REACT:R-HSA-445067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NrCAM binds axonin-1 (Homo sapiens)
RHEA:60277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine
RHEA:37661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-methyl anthranilate => anthraniloyl-CoA + methanol
REACT:R-DDI-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
REACT:R-BTA-8858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF9 binds TNFRSF9 (Bos taurus)
REACT:R-BTA-2534248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP2, MMP3, MMP7 (Bos taurus)
REACT:R-DME-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Drosophila melanogaster)
REACT:R-DRE-5666070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Danio rerio)
REACT:R-MMU-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Mus musculus)
REACT:R-XTR-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Xenopus tropicalis)
REACT:R-DRE-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Danio rerio)
GO:0102934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	costunolide synthase activity
RHEA:52892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nitrosobenzene = H(+) + NADPH + nitrobenzene
RHEA:56958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + IDP + phosphoenolpyruvate => ITP + pyruvate
GO:0102431	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-linolenate delta5 desaturase activity
GO:0102431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate delta5 desaturase activity
GO:0102431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-lipid omega-(9-4) desaturase activity
GO:0102431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-lipid omega-(9-4) desaturase
RHEA:40603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)
REACT:R-HSA-8987105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)
REACT:R-GGA-198621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates caspase-9 (Gallus gallus)
REACT:R-DRE-2161651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGE2 is converted to PGF2a by CBR1 (Danio rerio)
REACT:R-RNO-3322422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits SMARCA4 (Rattus norvegicus)
REACT:R-HSA-452392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcription of POU5F1 (OCT4) (Homo sapiens)
REACT:R-CEL-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Caenorhabditis elegans)
RHEA:57313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => cytidine 5'-diphosphoramidate + H(+) + L-glutamate
REACT:R-SSC-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Sus scrofa)
REACT:R-HSA-5676917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Homo sapiens)
REACT:R-DME-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Drosophila melanogaster)
RHEA:40488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:59630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + L-arginine => H2O + N(2)-(4-aminobutanoyl)-L-arginine
RHEA:46019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20R)-20-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone
REACT:R-DRE-9008692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds SMAD3 (Danio rerio)
REACT:R-MMU-1474266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibrils (Mus musculus)
REACT:R-SCE-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Saccharomyces cerevisiae)
REACT:R-HSA-5620914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF4:GTP binds VxPx-motifs of membrane proteins (Homo sapiens)
REACT:R-MMU-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Mus musculus)
RHEA:50520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]
REACT:R-HSA-187045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The signal peptide is excised from beta-NGF pre-pro-precursor (Homo sapiens)
REACT:R-CFA-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Canis familiaris)
RHEA:61511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peonidin + UDP-alpha-D-glucose <=> peonidin 3-O-beta-D-glucoside + UDP
REACT:R-HSA-71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)
GO:0047495	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity
GO:0047495	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglycerol cyclase activity
GO:0047495	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	periplasmic phosphoglycerotransferase activity
GO:0047495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	membrane-oligosaccharide glycerophosphotransferase activity
REACT:R-HSA-936563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of DDX58 (Homo sapiens)
REACT:R-BTA-6807214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Bos taurus)
RHEA:55430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-388809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTLA-4 binds B7-1/B7-2 (Mus musculus)
REACT:R-SSC-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Sus scrofa)
RHEA:30979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-lycopene = AH2 + all-trans-3,4-didehydrolycopene
RHEA:23206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-caffeoylglucarate + L-quinate => chlorogenate + D-glucarate
GO:0003989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:carbon-dioxide ligase (ADP-forming)
GO:0003989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A carboxylase activity
GO:0003989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA carboxylase activity
REACT:R-BTA-3215448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Bos taurus)
REACT:R-SSC-375790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Sus scrofa)
RHEA:69615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:27952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) => L-phenylalanine(in)
REACT:R-SSC-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Sus scrofa)
REACT:R-HSA-163688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)
REACT:R-BTA-5607721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NIK (Bos taurus)
REACT:R-DRE-449077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-16 is secreted (Danio rerio)
REACT:R-RNO-1181153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Rattus norvegicus)
RHEA:63445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized coenzyme F420-0
REACT:R-MMU-8854466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds RELN (Mus musculus)
RHEA:44008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-methyl-branched fatty aldehyde + H2O + NAD(+) = a 2-methyl fatty acid + 2 H(+) + NADH
REACT:R-XTR-2046096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Xenopus tropicalis)
REACT:R-GGA-140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Gallus gallus)
RHEA:55038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N,N-dimethylornithine lipid + S-adenosyl-L-methionine
REACT:R-DRE-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Danio rerio)
REACT:R-BTA-981497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Bos taurus)
RHEA:29123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(out) + ubiquinol-8(in) = H2O(out) + nitrite(out) + ubiquinone-8(in)
GO:0042086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity
REACT:R-RNO-5610723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind SUFU (Rattus norvegicus)
RHEA:15564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + sterigmatocystin <=> 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine
GO:0050537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mandelamide hydrolase activity
GO:0050537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Pseudomonas mandelamide hydrolase activity
GO:0050537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mandelamide amidase activity
REACT:R-BTA-8866553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded CFTR is degraded by the 26S proteasome (Bos taurus)
RHEA:59869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine => 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)
RHEA:67139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + ADP + phosphate
REACT:R-HSA-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Homo sapiens)
RHEA:49205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
REACT:R-DDI-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Dictyostelium discoideum)
REACT:R-PFA-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-SSC-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Sus scrofa)
RHEA:66706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + mycophenolate => H2O + mycophenolyl-CoA
RHEA:72149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + S-adenosyl-L-methionine + UTP
REACT:R-CFA-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Canis familiaris)
REACT:R-RNO-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Rattus norvegicus)
REACT:R-CFA-9029561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to the ABCA1 promoter (Canis familiaris)
REACT:R-RNO-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)
REACT:R-HSA-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Homo sapiens)
REACT:R-DRE-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Danio rerio)
REACT:R-GGA-9724290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR2 binds GNRH1,2 (Gallus gallus)
REACT:R-DRE-9638075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from DS (Danio rerio)
RHEA:36225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-MMU-9657619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Mus musculus)
RHEA:26217	skos:altLabel	"abietadiene hydroxylase"
RHEA:26217	skos:prefLabel	"abieta-7,13-diene hydroxylase"
RHEA:26217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"abieta-7,13-diene hydroxylase"
RHEA:26217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:43795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(645) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine
EC:2.5.1.150	skos:prefLabel	"lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)"
EC:2.5.1.150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)"
RHEA:72266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + oxalate(in) <=> chloride(in) + oxalate(out)
REACT:R-MMU-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Mus musculus)
REACT:R-GGA-444476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPRL2 receptor binds a wide range of ligands (Gallus gallus)
REACT:R-MMU-165777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4B by activated S6K1 (Mus musculus)
RHEA:50841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate
RHEA:48894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O
REACT:R-DRE-9024872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 17(S)-Hp-DHA to PDX (Danio rerio)
RHEA:51109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:41385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-CEL-8937177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD binds ARNT (Caenorhabditis elegans)
REACT:R-CFA-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Canis familiaris)
REACT:R-GGA-5661125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2sR4-HIST1H4 (Gallus gallus)
REACT:R-DRE-5252079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Danio rerio)
REACT:R-DME-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Drosophila melanogaster)
REACT:R-DRE-5693536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDC1 (Danio rerio)
RHEA:39364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O
RHEA:34982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) <=> H(+)(out)
RHEA:30453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomultiflorenol => (S)-2,3-epoxysqualene
REACT:R-XTR-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Xenopus tropicalis)
REACT:R-RNO-2730861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Rattus norvegicus)
RHEA:12307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + L-2-aminoadipate + NADPH
REACT:R-CEL-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Caenorhabditis elegans)
REACT:R-BTA-391933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP3 receptor can bind PGE2 (Bos taurus)
RHEA:21728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-mannose 6-dehydrogenase"
RHEA:21728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH
RHEA:21728	skos:prefLabel	"GDP-mannose 6-dehydrogenase"
GO:0061759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate dehydrogenase activity, reverse reaction
GO:0061759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + AH2 => (S)-2-hydroxyglutarate + A
GO:0061759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate reductase activity
GO:0061759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-2HG reductase activity
GO:0061759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate reductase activity
GO:0061759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ketoglutarate reductase activity
REACT:R-DRE-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)
REACT:R-HSA-5625421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The anterograde IFT train dissociates (Homo sapiens)
RHEA:54743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-199298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CREB1 (Canis familiaris)
REACT:R-GGA-2453855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)
REACT:R-GGA-3928654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin internalises EPH:EFN complexes (Gallus gallus)
REACT:R-DRE-2029460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates LIMK1 (Danio rerio)
RHEA:71879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide
RHEA:49961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 => 5,10-dihydrophenazine + CO2 + H2O2
RHEA:31231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanal + H2O + NAD(+) = 4-acetamidobutanoate + 2 H(+) + NADH
REACT:R-RNO-1602398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Rattus norvegicus)
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligo-1,6-glucosidase activity
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-oligo-1,6-glucosidase activity
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	limit dextrinase
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-methylglucosidase activity
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextrin 6-glucanohydrolase activity
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrase-isomaltase activity
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isomaltase activity
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligosaccharide alpha-1,6-glucosidase activity
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextrin 6alpha-glucanohydrolase activity
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-limit dextrinase activity
GO:0004574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligosaccharide alpha-1,6-glucohydrolase activity
RHEA:33476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)
RHEA:20087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 3-O-beta-D-glucoside + malonyl-CoA
RHEA:43119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine
REACT:R-CEL-392195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi activation by P2Y purinoceptor 12 (Caenorhabditis elegans)
RHEA:51893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylcadaverine => acetate + cadaverine
REACT:R-MMU-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Mus musculus)
REACT:R-SSC-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Sus scrofa)
REACT:R-XTR-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Xenopus tropicalis)
RHEA:58527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)
RHEA:66315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-mannosylinositol-1-phosphoceramide + H2O <=> a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)
RHEA:18623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3R)-dihydroflavonol + CO2 + succinate => 2-oxoglutarate + a (2S)-flavan-4-one + O2
RHEA:64055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine
GO:0004776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity
GO:0004776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate:CoA ligase (GDP-forming) activity
GO:0004776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl CoA synthetase activity
GO:0004776	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinyl coenzyme A synthetase
GO:0004776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate-CoA ligase (GDP-forming) activity
GO:0004776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA synthetase (GDP-forming) activity
GO:0004776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl coenzyme A synthetase (GDP-forming) activity
REACT:R-GGA-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Gallus gallus)
REACT:R-DRE-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Danio rerio)
RHEA:49983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine
GO:0140752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched 1,3-beta-D-glucan synthase activity
REACT:R-HSA-170965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Frs2)Rap1-GTP binds to and activates B-Raf (Homo sapiens)
REACT:R-SSC-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Sus scrofa)
RHEA:67272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)
REACT:R-XTR-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Xenopus tropicalis)
RHEA:46084	skos:prefLabel	"glycerol-1-phosphatase"
RHEA:46084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 3-phosphate = glycerol + phosphate
RHEA:46084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 1-phosphate = glycerol + phosphate
RHEA:46084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-1-phosphatase"
GO:0140306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoprotein releasing activity
REACT:R-SSC-209815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is monoiodinated (Sus scrofa)
RHEA:51626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dGTP + H2O => formate + GTP + H(+)
RHEA:50874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2
REACT:R-DDI-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Dictyostelium discoideum)
REACT:R-PFA-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Plasmodium falciparum)
REACT:R-CEL-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Caenorhabditis elegans)
RHEA:34033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + paromamine => 2'-N-acetylparomamine + H2O
GO:0043865	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methionine importing activity
GO:0043865	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methionine importer activity
GO:0043865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine importer
GO:0043865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine transmembrane transporter activity
GO:0043865	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methionine-importing activity
REACT:R-MMU-3134883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin enhances association of IRF3 with CBP/p300  (Mus musculus)
REACT:R-SSC-373358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR6 binds CXCL16 ligand (Sus scrofa)
REACT:R-DRE-5690080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP3,SAGA deubiquitinate Histone H2A,H2B (Danio rerio)
RHEA:21934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homoserine lactone + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine
REACT:R-BTA-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Bos taurus)
RHEA:17843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP => trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-HSA-9669890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation of kinase domain KIT mutants (Homo sapiens)
REACT:R-BTA-5686924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Bos taurus)
REACT:R-SSC-9734070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET recombinant therapeutic antibodies bind MET (Sus scrofa)
REACT:R-XTR-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Xenopus tropicalis)
REACT:R-HSA-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Homo sapiens)
RHEA:13106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 2-phosphate + H2O => glycerol + phosphate
REACT:R-CFA-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)
RHEA:12270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline + H2O + L-glutamate => 2-oxoglutarate + putrescine
REACT:R-BTA-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Bos taurus)
RHEA:31325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose
REACT:R-XTR-5218838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXN binds p-6Y,S732-PTK2 (Xenopus tropicalis)
REACT:R-SCE-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Saccharomyces cerevisiae)
REACT:R-RNO-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Rattus norvegicus)
RHEA:15648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] <=> 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate
RHEA:15278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysyl-[alpha-tubulin] => CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]
REACT:R-BTA-4551451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)
REACT:R-GGA-9704248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM4 binds CHRM4 antagonists (Gallus gallus)
GO:0050538	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-carbamoylase activity
GO:0050538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-carbamoyl-L-amino-acid hydrolase activity
GO:0050538	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-carbamoyl-L-amino acid amidohydrolase activity
RHEA:48118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine
REACT:R-HSA-4755419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1H4 with SUMO1 (Homo sapiens)
REACT:R-DRE-212380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TRAP coactivator complex (Danio rerio)
RHEA:49171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-159762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
REACT:R-BTA-437118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI stimulates PI3K beta, gamma (Bos taurus)
RHEA:32270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + glyoxylate <=> glycine + succinate semialdehyde
REACT:R-MMU-139919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BIM to mitochondria (Mus musculus)
GO:0035197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small interfering RNA binding
GO:0035197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	siRNA binding
REACT:R-CEL-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Caenorhabditis elegans)
REACT:R-HSA-2161790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20cooh-LTB4 is converted to 18cooh-LTB4 (Homo sapiens)
REACT:R-SSC-9674127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Sus scrofa)
REACT:R-MMU-197250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)
REACT:R-SSC-71825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Sus scrofa)
REACT:R-HSA-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Homo sapiens)
GO:0022855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose PTS transporter activity
GO:0022855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity
REACT:R-CEL-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Caenorhabditis elegans)
REACT:R-HSA-9615937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPNO/KPNB1 (transportin/importin beta) sequester the Nup107-160 complex (Homo sapiens)
GO:0106388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18S rRNA aminocarboxypropyltransferase activity
GO:0106388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine
REACT:R-HSA-9008696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) translocates from the cytosol to the nucleus (Homo sapiens)
REACT:R-BTA-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Bos taurus)
REACT:R-HSA-9694551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3CLp cleaves nsp6-11 (Homo sapiens)
REACT:R-BTA-1112602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)
GO:0051010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule plus-end binding
RHEA:17912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate <=> acetaldehyde + formate
RHEA:55527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-dopa + O2 <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)
RHEA:15424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + CoA <=> a long-chain fatty acyl-CoA + AMP + diphosphate
RHEA:39273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z)-tetracosadienoyl-CoA + H2O => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA
RHEA:53049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone + UDP-alpha-D-glucuronate => 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-HSA-5668404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFA binds TNFR2 (Homo sapiens)
RHEA:25150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde <=> H(+) + H2O + quinolinate
RHEA:46653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone + H(+) + NADPH => 5beta-dihydroepitestosterone + NADP(+)
RHEA:14461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sarsapogenin 3beta-glucosyltransferase"
RHEA:14461	skos:prefLabel	"sarsapogenin 3beta-glucosyltransferase"
RHEA:14461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP
REACT:R-GGA-6804468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO2 (Gallus gallus)
REACT:R-HSA-9026502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTF3-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)
REACT:R-MMU-444476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPRL2 receptor binds a wide range of ligands (Mus musculus)
RHEA:69124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-tryptophan = glycine + indole-3-pyruvate
REACT:R-SPO-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Schizosaccharomyces pombe)
REACT:R-CEL-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Caenorhabditis elegans)
REACT:R-RNO-448703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family precursors are cleaved by caspase-1 (Rattus norvegicus)
REACT:R-HSA-8952823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Homo sapiens)
REACT:R-XTR-1112602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Xenopus tropicalis)
RHEA:40359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DME-937034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino (Drosophila melanogaster)
RHEA:51761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate
GO:0001858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component iC3b receptor activity
REACT:R-DRE-4656914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKBIA with SUMO1 (Danio rerio)
REACT:R-PFA-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Plasmodium falciparum)
REACT:R-DRE-4568848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Danio rerio)
GO:0008143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyadenylate binding
GO:0008143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly-A binding
GO:0008143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(A) binding
GO:0008143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(A) binding, within an RNA molecule
GO:0008143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(rA) binding
REACT:R-DRE-389158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
REACT:R-SSC-606349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mis18 complex binds the centromere (Sus scrofa)
RHEA:65659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cholest-1,4-dien-3-one + H2O <=> 25-hydroxycholest-1,4-dien-3-one + AH2
REACT:R-CEL-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:13010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-kynurenine => formate + H(+) + L-kynurenine
GO:0019914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin-dependent protein kinase activating kinase regulator activity
GO:0019914	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclin-dependent protein kinase activating kinase, intrinsic regulator activity
RHEA:19337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH
RHEA:19337	skos:prefLabel	"hyponitrite reductase"
RHEA:19337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hyponitrite reductase"
RHEA:19337	skos:altLabel	"NADH:hyponitrite oxidoreductase"
REACT:R-CEL-451418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates IRAK1 (Caenorhabditis elegans)
RHEA:34934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathioselenol + NADPH <=> glutathione + hydrogenselenide + NADP(+)
REACT:R-RNO-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Rattus norvegicus)
REACT:R-HSA-9665708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 TMD/JMD mutants do not bind pertuzumab (Homo sapiens)
REACT:R-GGA-8853753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Gallus gallus)
RHEA:13697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribokinase"
RHEA:13697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)
RHEA:13697	skos:prefLabel	"ribokinase"
RHEA:43558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O
REACT:R-HSA-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Homo sapiens)
REACT:R-BTA-6805620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A and PML bind TP53 (Bos taurus)
REACT:R-PFA-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Plasmodium falciparum)
REACT:R-XTR-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Xenopus tropicalis)
REACT:R-GGA-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Gallus gallus)
REACT:R-MMU-5690740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds B-cell receptor (Mus musculus)
REACT:R-BTA-6788392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Bos taurus)
RHEA:13996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-2-methylpropanoate + 2-oxoglutarate <=> 2-methyl-3-oxopropanoate + L-glutamate
REACT:R-HSA-2076383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3ST1 sulfates GlcN at C3 in heparan sulfate (Homo sapiens)
REACT:R-HSA-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Homo sapiens)
REACT:R-HSA-6809238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR7 binds MTMR9 (Homo sapiens)
REACT:R-RNO-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Rattus norvegicus)
REACT:R-XTR-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Xenopus tropicalis)
REACT:R-XTR-1606288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Xenopus tropicalis)
GO:0004516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinic acid mononucleotide glycohydrolase activity
GO:0004516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinic acid mononucleotide pyrophosphorylase activity
GO:0004516	skos:altLabel	"nicotinic acid mononucleotide pyrophosphorylase"
GO:0004516	skos:altLabel	"niacin ribonucleotidase"
GO:0004516	skos:prefLabel	"nicotinate phosphoribosyltransferase"
GO:0004516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinic acid phosphoribosyltransferase activity
GO:0004516	skos:altLabel	"nicotinic acid mononucleotide glycohydrolase"
GO:0004516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
GO:0004516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	niacin ribonucleotidase activity
GO:0004516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate
GO:0004516	skos:altLabel	"nicotinic acid phosphoribosyltransferase"
GO:0004516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinate phosphoribosyltransferase"
GO:0004516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate phosphoribosyltransferase activity
RHEA:38426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)
RHEA:15478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 5beta-scymnol => 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-1982066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent phosphorylation of overexpressed FGFR1 (Homo sapiens)
RHEA:21297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + NAD(+) => D-galactono-1,4-lactone + H(+) + NADH
REACT:R-RNO-3149519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC decyanates CNCbl (Rattus norvegicus)
RHEA:71619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + 2 thiosulfate(out) = (S)-malate(out) + 2 thiosulfate(in)
REACT:R-CEL-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Caenorhabditis elegans)
REACT:R-HSA-9707659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes:LY96 activates TLR4 (Homo sapiens)
REACT:R-DRE-450595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR:mRNA complex translocates from the nucleus to the cytosol (Danio rerio)
REACT:R-MMU-9716258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimethyl fumarate modifies Cys191 in GSDMD (Mus musculus)
RHEA:32351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 S-adenosyl-L-methionine + tricetin = 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine
RHEA:32351	skos:prefLabel	"tricetin 3',4',5'-O-trimethyltransferase"
RHEA:32351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tricetin 3',4',5'-O-trimethyltransferase"
RHEA:25357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanal + formyl-CoA => 2-hydroxyphytanoyl-CoA
REACT:R-DME-428609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type I Na+-coupled phosphate co-transport (Drosophila melanogaster)
GO:0016167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDNF receptor activity
GO:0016167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glial cell line-derived neurotrophic factor receptor activity
GO:0016167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glial cell-derived neurotrophic factor receptor activity
REACT:R-HSA-1839039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation (Homo sapiens)
REACT:R-HSA-202174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ZAP-70 (Homo sapiens)
REACT:R-CFA-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Canis familiaris)
REACT:R-BTA-6814153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADO oxidises 2AET to HTAU (Bos taurus)
REACT:R-XTR-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Xenopus tropicalis)
RHEA:37892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin T + H2O => 15-demethylaclacinomycin T + methanol
REACT:R-HSA-198613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates p21Cip1 and p27Kip1 (Homo sapiens)
GO:0023028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class I protein binding, via lateral surface
REACT:R-DRE-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Danio rerio)
RHEA:29221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + dihydroxyacetone phosphate => a menaquinone + sn-glycerol 3-phosphate
RHEA:36448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-proline(out) + H2O => ADP + glycyl-L-proline(in) + H(+) + phosphate
REACT:R-GGA-1112755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds IL6ST (Gallus gallus)
RHEA:34472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADH
REACT:R-CFA-9027302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)
RHEA:69130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + glycine => glyoxylate + L-leucine
RHEA:57158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2
RHEA:19088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
RHEA:66344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate
REACT:R-HSA-202721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 binds JAM3 (Homo sapiens)
RHEA:55057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:35861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA
EC:1.3.99.37	skos:prefLabel	"1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase"
EC:1.3.99.37	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase"
REACT:R-DME-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Drosophila melanogaster)
GO:0047678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine oxygenase (decarboxylating) activity
GO:0047678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine 2-monooxygenase activity
GO:0047678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine:oxygen 2-oxidoreductase (decarboxylating)
GO:0047678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine monooxygenase activity
GO:0047678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine decarboxy-oxidase activity
REACT:R-SSC-6807229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)
RHEA:48761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threitol + NAD(+) => H(+) + L-erythrulose + NADH
REACT:R-CEL-4608855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRICKLE1 is degraded by the proteasome (Caenorhabditis elegans)
RHEA:60631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + gluconapin + O2 <=> A + H2O + progoitrin
REACT:R-RNO-192475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Rattus norvegicus)
REACT:R-HSA-426223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cation influx mediated by TRPC3/6/7 (Homo sapiens)
RHEA:67287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione <=> (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione
REACT:R-HSA-9757459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST metabolites diffuse out of ER lumen (Homo sapiens)
REACT:R-GGA-8983384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Gallus gallus)
RHEA:17348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + H2O <=> CoA + H(+) + methylmalonate
REACT:R-HSA-8948224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)
RHEA:17390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NAD(+) => D-ribulose + H(+) + NADH
RHEA:56972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-2-methylpropanoate + NAD(+) = (R)-methylmalonate semialdehyde + H(+) + NADH
REACT:R-MMU-9020261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Mus musculus)
REACT:R-PFA-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Plasmodium falciparum)
REACT:R-SSC-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Sus scrofa)
RHEA:29895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine(out) = ADP + H(+) + L-glutamine(in) + phosphate
REACT:R-DRE-140777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Danio rerio)
REACT:R-GGA-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Gallus gallus)
GO:0047932	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine acetyltransferase activity
GO:0047932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosamine N-acetyltransferase activity
GO:0047932	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine acetylase activity
GO:0047932	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:D-glucosamine N-acetyltransferase activity
REACT:R-HSA-174624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR (Homo sapiens)
REACT:R-SSC-508451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B is phosphorylated (Sus scrofa)
RHEA:64549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]
RHEA:22891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-methylmalonyl-CoA <=> succinyl-CoA
RHEA:39035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-hydroxy fatty acid + NAD(+) = an omega-oxo fatty acid + H(+) + NADH
REACT:R-MMU-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Mus musculus)
REACT:R-BTA-8875576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK,CRKL recruits RAC1 GEF to activated MET (Bos taurus)
REACT:R-HSA-5621347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)
GO:0005436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sodium-dependent phosphate transmembrane transporter activity
GO:0005436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/phosphate symporter activity
GO:0005436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:phosphate symporter activity
REACT:R-GGA-141422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 converted  to an inhibitory state via interaction with Mad1 (Gallus gallus)
REACT:R-SSC-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Sus scrofa)
RHEA:60286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine
REACT:R-MMU-1912394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 in complex with RBPJ (CSL) recruits MAML (Mus musculus)
RHEA:68102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-xylulose + NADH => NAD(+) + xylitol
GO:0031845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 5 neuropeptide Y receptor binding
GO:0031845	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 5 neuropeptide Y receptor ligand
REACT:R-XTR-1067651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Xenopus tropicalis)
RHEA:23537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate => alpha-D-glucose 6-phosphate
GO:0034816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthracene 9,10-dioxygenase activity
REACT:R-CFA-388817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICOS binds ICOSL/B7-H2 (Canis familiaris)
RHEA:48960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O
REACT:R-CFA-8855237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Canis familiaris)
RHEA:24525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-193776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Efflux of 24-hydroxycholesterol (Homo sapiens)
REACT:R-HSA-9702578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	semaxanib-resistant FLT3 mutants don't bind semaxanib<br> (Homo sapiens)
REACT:R-GGA-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Gallus gallus)
RHEA:27677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dADP <=> ADP + dATP
RHEA:41064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:45378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine
REACT:R-MMU-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Mus musculus)
REACT:R-RNO-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Rattus norvegicus)
RHEA:29184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + 2 O2 => 2 H(+) + menaquinone-8 + 2 superoxide
REACT:R-BTA-9653503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B is phosphorylated on serine 181 (Bos taurus)
REACT:R-CFA-194017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 11DCORST to CORST (Canis familiaris)
RHEA:27890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-UMP + H2O = phosphate + uridine
RHEA:32892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S)-alpha-pinene + H(+) + NADH + O2 => alpha-pinene oxide + H2O + NAD(+)
RHEA:66206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-heptenoyl-CoA + H2O2 => heptanoyl-CoA + O2
RHEA:55603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphoceramide + GDP + H(+)
GO:0043559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin binding
REACT:R-DRE-9668904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18 complex (Danio rerio)
REACT:R-DRE-1855171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Danio rerio)
REACT:R-DME-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Drosophila melanogaster)
RHEA:70541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+) => GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein]
REACT:R-GGA-442291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV2 is a GEF for Rho/Rac family kinases (Gallus gallus)
REACT:R-SSC-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Sus scrofa)
RHEA:31869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baccharis oxide => (S)-2,3-epoxysqualene
RHEA:66545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]
RHEA:64229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:16924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-XTR-5666088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP recruits DAIPH2-3 to endosomes (Xenopus tropicalis)
RHEA:30580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-threonine => L-threonine + phosphate
REACT:R-CFA-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Canis familiaris)
REACT:R-MMU-392263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR2 (Mus musculus)
REACT:R-GGA-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Gallus gallus)
RHEA:48040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + H2O = globoside Gb3Cer + N-acetyl-beta-D-galactosamine
RHEA:28565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate
RHEA:32537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxohexanoate => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O
REACT:R-RNO-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Rattus norvegicus)
REACT:R-RNO-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Rattus norvegicus)
GO:0018719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-aminohexanoate transaminase activity
RHEA:68270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + H2O + NADP(+) => dUMP + formaldehyde + H(+) + NADPH
REACT:R-HSA-8877490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXP3 in complex with RUNX1 binds to the TNFRSF18 (GITR) gene intron 1 (Homo sapiens)
REACT:R-CFA-419841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Light stimulates opsin receptors (Canis familiaris)
REACT:R-SCE-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Saccharomyces cerevisiae)
RHEA:24285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate 4-semialdehyde + NADP(+) + phosphate => 4-phospho-L-aspartate + H(+) + NADPH
GO:0047185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminate 4-O-acetyltransferase activity
GO:0047185	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sialate O-acetyltransferase
GO:0047185	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity
RHEA:22237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate
RHEA:72696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) => UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)
REACT:R-DRE-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Danio rerio)
GO:0009032	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyrimidine phosphorylase activity
GO:0009032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine phosphorylase activity
GO:0009032	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity
GO:0009032	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine:phosphate deoxy-D-ribosyltransferase activity
GO:0009032	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine-orthophosphate deoxyribosyltransferase activity
REACT:R-DRE-1295540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Danio rerio)
RHEA:37414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklavinone + NADP(+) <=> aklaviketone + 2 H(+) + NADPH
REACT:R-SSC-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Sus scrofa)
RHEA:70539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] = 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)
RHEA:31173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA + H2O => (3S)-hydroxytetradecanoyl-CoA
RHEA:14104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-deoxyhypusine + AH2 + O2 <=> [eIF5A protein]-hypusine + A + H2O
RHEA:40727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate
REACT:R-BTA-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Bos taurus)
REACT:R-HSA-8963872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 translocates from ER membrane to extracellular region (Homo sapiens)
GO:0019778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Atg12 activating enzyme activity
GO:0019778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APG12 activating enzyme activity
RHEA:28003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone
EC:3.4.21.74	skos:prefLabel	"venombin A"
EC:3.4.21.74	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"venombin A"
REACT:R-CFA-389762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PD-1 (Canis familiaris)
RHEA:57356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chloride + H(+) + hapalindole U + O2 = CO2 + H2O + hapalindole G + succinate
REACT:R-DRE-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Danio rerio)
REACT:R-HSA-8964550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds E2F1 gene promoter (Homo sapiens)
RHEA:50921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => chromopyrrolate + H(+) + 2 H2O + NH4(+)
REACT:R-MTU-879248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desacetylmycothiol is acetylated to mycothiol using acetyl-CoA (Mycobacterium tuberculosis)
RHEA:19555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole + NH4(+) + pyruvate => H2O + L-tryptophan
REACT:R-HSA-9664918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)
RHEA:58449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-HSA-9627350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) binds XIAP (Homo sapiens)
RHEA:48768	skos:prefLabel	"D-erythrulose 4-kinase"
RHEA:48768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-erythrulose = ADP + D-erythrulose 4-phosphate + H(+)
RHEA:48768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-erythrulose 4-kinase"
REACT:R-CEL-390593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Caenorhabditis elegans)
REACT:R-DRE-5618073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Danio rerio)
RHEA:34989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(out) => (S)-lactate(in)
RHEA:44407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-7 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-7
REACT:R-MMU-198315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)
REACT:R-RNO-74247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Rattus norvegicus)
REACT:R-BTA-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Bos taurus)
REACT:R-MMU-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Mus musculus)
REACT:R-MMU-8875558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 binds CRK,CRKL (Mus musculus)
REACT:R-MMU-3222128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOC2L binds TP53 (Mus musculus)
REACT:R-SPO-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Schizosaccharomyces pombe)
REACT:R-MMU-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Mus musculus)
RHEA:61958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-RNO-5665809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Rattus norvegicus)
REACT:R-CFA-5610726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The IFT-A complex recruits TULP3 (Canis familiaris)
RHEA:71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + L-valine(in) => L-phenylalanine(in) + L-valine(out)
RHEA:20608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine + H(+) + H2O <=> NH4(+) + uracil
RHEA:39772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0016405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-ligase activity
REACT:R-SSC-8851494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase7 hydrolyzes nucleoside triphosphates (Sus scrofa)
REACT:R-HSA-1236967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alkalization of the phagosomal lumen by NOX2 (Homo sapiens)
REACT:R-HSA-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Homo sapiens)
RHEA:70852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) => H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)
REACT:R-DME-8870489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA4,(5,6) bind PI3P (Drosophila melanogaster)
REACT:R-HSA-8964475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DREAM complex binds the TOP2A gene promoter (Homo sapiens)
REACT:R-MMU-9691174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the ER membrane (Mus musculus)
RHEA:54665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene => pre-alpha-onocerin
RHEA:16531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + phosphate => ADP + H(+) + sulfate
REACT:R-DRE-381500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin G proteolyzes IGF:IGFBP3:ALS (Danio rerio)
RHEA:59676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraose + O2 = D-maltotetraono-1,5-lactone + H2O2
GO:0140693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phase separation nucleation activity
GO:0140693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phase separation nucleator activity
GO:0140693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular condensate scaffold activity
REACT:R-GGA-429449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk activation leads to SLP-76 activation (Gallus gallus)
GO:0017150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUS2:EPRS reduces uridine to dihydrouridine in tRNAs (Homo sapiens)
GO:0017150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA dihydrouridine synthase activity
REACT:R-XTR-9733973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts bind FABP6 (Xenopus tropicalis)
RHEA:52924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-XTR-5654586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)
REACT:R-CFA-9009910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds p-S423,S425-SMAD3 (Canis familiaris)
REACT:R-RNO-9014424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the phagocytic vesicle membrane (Rattus norvegicus)
REACT:R-DME-5696365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Drosophila melanogaster)
REACT:R-HSA-2465941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A REH hydrolyses 11cRE to 11cROL (Homo sapiens)
RHEA:71354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone 3alpha-sulfate(out) + 2 Na(+)(out) <=> androsterone 3alpha-sulfate(in) + 2 Na(+)(in)
REACT:R-RNO-450133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP binds MYD88 homodimer (Rattus norvegicus)
REACT:R-RNO-202214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)
REACT:R-DDI-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Dictyostelium discoideum)
REACT:R-XTR-193393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Xenopus tropicalis)
RHEA:40839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + nonanoyl-CoA = (2E)-nonenoyl-CoA + FADH2
REACT:R-RNO-141348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAO:FAD oxidises NASPM to PTCN (Rattus norvegicus)
REACT:R-SPO-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)
RHEA:71973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyglutarate(in) + 3 Na(+)(in) => 3-hydroxyglutarate(out) + 3 Na(+)(out)
REACT:R-DRE-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Danio rerio)
REACT:R-HSA-9694662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 3a forms a homotetramer (Homo sapiens)
RHEA:12011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[G-protein-coupled receptor] + ATP <=> [G-protein-coupled receptor]-phosphate + ADP + H(+)
REACT:R-HSA-9009817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acitretin binds to RAR:RXR (Homo sapiens)
RHEA:43993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 => 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)
REACT:R-GGA-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Gallus gallus)
RHEA:31215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) = (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH
REACT:R-RNO-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Rattus norvegicus)
REACT:R-CEL-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
RHEA:53659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate
RHEA:49415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose <=> alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)
REACT:R-CFA-198266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
RHEA:38941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose => dioscin + 2 H2O
REACT:R-BTA-158893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Bos taurus)
RHEA:21337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pyridoxal => 4-pyridoxolactone + H(+) + NADH
REACT:R-DRE-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)
REACT:R-RNO-2213243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of COPII vesicle with Golgi complex (Rattus norvegicus)
REACT:R-MMU-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Mus musculus)
REACT:R-RNO-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Rattus norvegicus)
GO:0005136	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-4 receptor ligand
GO:0005136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-4 receptor binding
GO:0005136	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-4
REACT:R-RNO-9627107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP7 (Rattus norvegicus)
REACT:R-HSA-5686072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-3Y-SHC1 dissociates from IGF1R (Homo sapiens)
REACT:R-GGA-8936608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)
RHEA:10522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose
RHEA:60687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADPH
REACT:R-HSA-9020262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Homo sapiens)
GO:0102572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-glutamylanilide hydrolase activity
RHEA:16834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + H2O2 => glutathione disulfide + 2 H2O
REACT:R-HSA-400027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma (Homo sapiens)
REACT:R-MMU-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Mus musculus)
REACT:R-DDI-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Dictyostelium discoideum)
REACT:R-BTA-4755479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKB2 with SUMO1 (Bos taurus)
REACT:R-MMU-9773803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKBKB phosphorylates NF-kappa-B inhibitor  (Mus musculus)
REACT:R-MMU-5693583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDC1 associates with gamma-H2AFX at nuclear foci (Mus musculus)
RHEA:62162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl) ethanolamine + phosphate => H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate
RHEA:59624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(4-aminobutanoyl)-L-ornithine = 4-aminobutanoate + L-ornithine
REACT:R-XTR-9709317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to free ferrohemoglobin (Xenopus tropicalis)
RHEA:28807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione gamma-glutamate hydrolase"
RHEA:28807	skos:altLabel	"glutathionase"
RHEA:28807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + H2O = L-cysteinylglycine + L-glutamate
RHEA:28807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
RHEA:28807	skos:altLabel	"gamma-glutamyltranspeptidase"
RHEA:28807	skos:prefLabel	"glutathione gamma-glutamate hydrolase"
REACT:R-MMU-9009554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer:SDC1 binds CSF1R (Mus musculus)
RHEA:57103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thio-D-xylulose 5-phosphate
GO:0080075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine:feruloyl CoA N-acyltransferase activity
REACT:R-XTR-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Xenopus tropicalis)
REACT:R-CFA-109822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Canis familiaris)
RHEA:56700	skos:prefLabel	"3-[(Z)-2-isocyanoethenyl]-1H-indole synthase"
RHEA:56700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-[(Z)-2-isocyanoethenyl]-1H-indole synthase"
RHEA:56700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate
RHEA:71599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + maleate(in) = 2-oxoglutarate(in) + maleate(out)
RHEA:59754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-CoA
REACT:R-XTR-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Xenopus tropicalis)
REACT:R-CFA-1632843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1 binds DYNLL1,DYNLL2 (Canis familiaris)
GO:0010349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-galactose 1-dehydrogenase activity
GO:0010349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactose dehydrogenase activity
REACT:R-SSC-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Sus scrofa)
REACT:R-DME-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Drosophila melanogaster)
REACT:R-HSA-9007882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 is cleaved (Homo sapiens)
REACT:R-DDI-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Dictyostelium discoideum)
REACT:R-HSA-6802914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
REACT:R-HSA-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Homo sapiens)
GO:0051264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monooleoylglycerol O-acyltransferase activity
GO:0051264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOG transacylation
GO:0051264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoolein transacylation
GO:0051264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA-independent mono-olein transacylation
GO:0051264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mono-olein transacylation activity
GO:0051264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monooleoylglycerol transacylase activity
GO:0051264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mono-oleoylglycerol O-acyltransferase activity
GO:0051264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mono-oleoylglycerol transacylase activity
REACT:R-SSC-5682794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM22 and ADAM23 (Sus scrofa)
REACT:R-DME-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Drosophila melanogaster)
REACT:R-DRE-5665999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 translocates from cytosol to the nucleus (Danio rerio)
RHEA:61460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in RNA + S-adenosyl-L-methionine = a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine
RHEA:48692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
REACT:R-HSA-9605051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PCK1 regulated by NR1H3 (Homo sapiens)
RHEA:17964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> H2O + leukotriene A4
REACT:R-GGA-2730894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB1:RELA translocates from the cytosol to the nucleus (Gallus gallus)
RHEA:17301	skos:altLabel	"branched-chain oxo acid dehydrogenase kinase (phosphorylating)"
RHEA:17301	skos:altLabel	"BCK"
RHEA:17301	skos:altLabel	"branched-chain alpha-ketoacid dehydrogenase kinase"
RHEA:17301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]
RHEA:17301	skos:altLabel	"BCODH kinase"
RHEA:17301	skos:altLabel	"branched-chain 2-oxo acid dehydrogenase kinase"
RHEA:17301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase"
RHEA:17301	skos:altLabel	"branched-chain keto acid dehydrogenase kinase"
RHEA:17301	skos:altLabel	"BCKD kinase"
RHEA:17301	skos:prefLabel	"[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase"
REACT:R-GGA-5685902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Gallus gallus)
REACT:R-DME-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
RHEA:14848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate 4-semialdehyde + pyruvate <=> (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O
RHEA:69054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+) => H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2
REACT:R-RNO-4332235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds TGFBR2 (Rattus norvegicus)
RHEA:65040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:64019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)
RHEA:28753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + ubiquinol-8 => sn-glycerol 3-phosphate + ubiquinone-8
GO:0140332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intermembrane lipopolysaccharide transfer activity
GO:0140332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide transfer activity
GO:0140332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intermembrane lipopolysaccharide transporter activity
GO:0140332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intermembrane LPS transporter activity
GO:0140332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide carrier activity
GO:0005309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine:sodium symporter activity
GO:0005309	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium/chloride-dependent creatine transporter
GO:0005309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Creatine transport across the plasma membrane (Homo sapiens)
REACT:R-SSC-3341296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX7,8 catalyze peroxidation of P4HB (PDI) (Sus scrofa)
RHEA:14796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyadipate + NAD(+) <=> 2-oxoadipate + H(+) + NADH
RHEA:40171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2
REACT:R-BTA-77319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Bos taurus)
REACT:R-DRE-390598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Danio rerio)
REACT:R-DRE-158278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Danio rerio)
RHEA:13144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA <=> butanoyl-CoA
RHEA:38008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Drosophila melanogaster)
RHEA:70116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Gallus gallus)
GO:0005334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norepinephrine transmembrane transporter activity
GO:0005334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	levarterenol transporter activity
GO:0005334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norepinephrine:sodium symporter activity
GO:0005334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	noradrenaline transporter activity
GO:0005334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norepinephrine:sodium:chloride symporter activity
GO:0005334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/norepinephrine symporter activity
RHEA:14395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine => N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine
RHEA:23321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophan + malonyl-CoA => CoA + H(+) + N(2)-malonyl-D-tryptophan
REACT:R-GGA-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Gallus gallus)
RHEA:18818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + malonate => acetate + malonyl-CoA
RHEA:53435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:69963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone
RHEA:66788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-L-dopa + O2 = (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2
RHEA:66407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O + taurocholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)
RHEA:39822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:58005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside F2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP
GO:0008118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SiaT
GO:0008118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity
GO:0008118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity
GO:0008118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha2->3 sialyltransferase activity
GO:0008118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyllactosaminide alpha-2,3-sialyltransferase activity
REACT:R-RNO-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Rattus norvegicus)
REACT:R-SCE-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Saccharomyces cerevisiae)
RHEA:67080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + H(+) + phosphate
REACT:R-CEL-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Caenorhabditis elegans)
REACT:R-HSA-1638032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Homo sapiens)
GO:0047472	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-carboxymuconate cycloisomerase type II activity
GO:0047472	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-carboxymuconolactone hydrolase activity
GO:0047472	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-carboxymuconate lactonizing enzyme activity
GO:0047472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-cis,cis-muconate cycloisomerase activity
GO:0047472	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-carboxymuconate lactonizing enzyme activity
GO:0047472	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMLE activity
RHEA:69932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine(out) + Na(+)(out) => inosine(in) + Na(+)(in)
GO:0033679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 3'-5' DNA/RNA helicase activity
GO:0033679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 3' to 5' DNA/RNA helicase activity
GO:0033679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5' DNA/RNA helicase activity
GO:0033679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' to 5' DNA/RNA helicase activity
REACT:R-CEL-8956659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates YAP1 (Caenorhabditis elegans)
REACT:R-DME-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Drosophila melanogaster)
RHEA:66590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 26S rRNA + S-adenosyl-L-methionine
REACT:R-DDI-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Dictyostelium discoideum)
REACT:R-SPO-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Schizosaccharomyces pombe)
RHEA:43182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine
REACT:R-BTA-71260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Bos taurus)
REACT:R-HSA-176604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Homo sapiens)
RHEA:26083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:38882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(in) <=> a fatty acid(out)
REACT:R-BTA-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Bos taurus)
RHEA:39231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-triacontanoyl-CoA + H(+) + NADPH = (3R)-hydroxytriacontanoyl-CoA + NADP(+)
RHEA:31830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-gamma-cadinene + diphosphate
GO:0050512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactosylceramide 4-alpha-galactosyltransferase activity
GO:0050512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Gal-beta-1,4-Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity
GO:0050512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity
GO:0050512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histo-blood group Pk UDP-galactose
GO:0050512	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histo-blood group P(k) UDP-galactose activity
GO:0050512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactosylceramide 4-a-galactosyltransferase activity
GO:0050512	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	globotriaosylceramide/CD77 synthase activity
GO:0050512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Gal-beta-(1,4)-Glc-beta-1-Cer alpha-(1,4)-galactosyltransferase activity
RHEA:49900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine-1,6-dicarboxylate + O2 = H2O2 + phenazine-1,6-dicarboxylate
REACT:R-HSA-173481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Homo sapiens)
GO:0039631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	viral DNA packaging activity
GO:0039631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	viral DNA packaging motor activity
GO:0039631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA translocase activity involved in viral DNA genome packaging
RHEA:66001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)
GO:0008551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cadmium transmembrane transporter activity, phosphorylative mechanism
GO:0008551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Cd2+-exporting ATPase activity
GO:0008551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadmium-translocating P-type ATPase activity
GO:0008551	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cadmium-exporting ATPase activity
GO:0008551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type cadmium transporter activity
GO:0008551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadmium exporting ATPase activity
GO:0008551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Cd(2+)-exporting ATPase activity
REACT:R-BTA-1169192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B dephosphorylates GHR (Bos taurus)
REACT:R-RNO-193763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)
RHEA:27916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O
REACT:R-BTA-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Bos taurus)
REACT:R-HSA-9018874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP monooxygenates EPA to 18(S)-HpEPE (Homo sapiens)
REACT:R-SSC-163214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from reduced cytochrome c to molecular oxygen (Sus scrofa)
RHEA:70507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O = dimethylallyl phosphate + H(+) + phosphate
RHEA:30967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9',15-tri-cis-zeta-carotene = 9,9'-di-cis-zeta-carotene
RHEA:30967	skos:altLabel	"15-cis-zeta-carotene isomerase"
RHEA:30967	skos:prefLabel	"zeta-carotene isomerase"
RHEA:30967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zeta-carotene isomerase"
RHEA:32144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) => L-arginine(out)
RHEA:58015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic tetraadenylate <=> 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate
REACT:R-RNO-9612501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates CREB1 (Rattus norvegicus)
GO:0022872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity
GO:0022872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannitol PTS transporter activity
GO:0030379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotensin receptor activity, non G protein coupled
GO:0030379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotensin receptor activity, non-G-protein coupled
GO:0030379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non G protein coupled neurotensin receptor activity
GO:0030379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotensin receptor activity, non-G protein-coupled
GO:0030379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-G-protein coupled neurotensin receptor activity
GO:0030379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-G-protein-coupled neurotensin receptor activity
REACT:R-CEL-8964599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Caenorhabditis elegans)
REACT:R-MMU-264997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cysteine to cystine in Proinsulin (Mus musculus)
REACT:R-GGA-6808566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHGA-derived peptide binds the bacterial cell surface (Gallus gallus)
REACT:R-SPO-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Schizosaccharomyces pombe)
REACT:R-RNO-4755479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKB2 with SUMO1 (Rattus norvegicus)
REACT:R-DDI-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Dictyostelium discoideum)
REACT:R-MMU-205306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP1 and KIT (Mus musculus)
RHEA:22929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanoyl-CoA + H2O => 4-aminobutanoyl-CoA + acetate
RHEA:59352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-lactose + O2 = H2O2 + lactobiono-1,5-lactone
REACT:R-DRE-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)
RHEA:68325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,5-bisphosphate + H2O => 1D-myo-inositol 2-phosphate + phosphate
REACT:R-DRE-3204311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOX1 oxidises PXL to PDXate (Danio rerio)
REACT:R-RNO-4551451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Rattus norvegicus)
REACT:R-BTA-450292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Bos taurus)
RHEA:22149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] => a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]
REACT:R-HSA-428888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ROBO1 by ABL kinase (Homo sapiens)
RHEA:36550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octadecanoyl)-sphinganine
RHEA:66859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 3 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
REACT:R-GGA-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
REACT:R-BTA-913360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF receptor alpha subunit binds GM-CSF (Bos taurus)
RHEA:46969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydroisopentenyldehydrorhodopin => AH2 + isopentenyldehydrorhodopin
RHEA:55887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[aequorin] + 3 Ca(2+) <=> [aequorin]--dioxetanone
REACT:R-DME-450620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S193-KSRP binds 14-3-3zeta in the nucleus (Drosophila melanogaster)
REACT:R-MMU-2396007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3 is phosphorylated by TBK1 (Mus musculus)
RHEA:66646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + trichobrasilenol => (2E,6E)-farnesyl diphosphate + H2O
RHEA:62824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)
REACT:R-DRE-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Danio rerio)
REACT:R-GGA-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Gallus gallus)
RHEA:47384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetoxyphenol + H2O = acetate + H(+) + hydroquinone
REACT:R-HSA-76426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-atom dealkylation of caffeine (Homo sapiens)
RHEA:13724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + testololactone <=> H(+) + testolate
REACT:R-CFA-141431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)
REACT:R-HSA-9672170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors (Homo sapiens)
REACT:R-HSA-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Homo sapiens)
RHEA:46117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-galactonate => D-glyceraldehyde + pyruvate
REACT:R-DRE-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Danio rerio)
REACT:R-PFA-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Plasmodium falciparum)
REACT:R-CFA-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Canis familiaris)
REACT:R-MMU-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Mus musculus)
GO:0000034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenase activity
GO:0000034	skos:altLabel	"adenase"
GO:0000034	skos:prefLabel	"adenine deaminase"
GO:0000034	skos:altLabel	"adenine aminase"
GO:0000034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine deaminase activity
GO:0000034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenine aminohydrolase activity
GO:0000034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenine deaminase"
GO:0000034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + H(+) + H2O = hypoxanthine + NH4(+)
GO:0000034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenine aminase activity
GO:0000034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADase activity
RHEA:24995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-2730892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV to p-SLP-76 (Mus musculus)
REACT:R-GGA-377186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Gallus gallus)
RHEA:29643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaose + H2O = alpha-D-glucose + D-maltohexaose
RHEA:61445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tetracycline + H(+) + NADPH + O2 => an 11a-hydroxytetracycline + H2O + NADP(+)
RHEA:15489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside oxidase (H2O2-forming)"
RHEA:15489	skos:prefLabel	"nucleoside oxidase (H2O2-forming)"
RHEA:15489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H2O + 2 O2 = 9-riburonosyladenine + H(+) + 2 H2O2
RHEA:16609	skos:altLabel	"APRT"
RHEA:16609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenine phosphoribosyltransferase"
RHEA:16609	skos:altLabel	"AMP pyrophosphorylase"
RHEA:16609	skos:altLabel	"transphosphoribosidase"
RHEA:16609	skos:altLabel	"AMP diphosphorylase"
RHEA:16609	skos:prefLabel	"adenine phosphoribosyltransferase"
RHEA:16609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine
REACT:R-HSA-9011300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZSWIM8 ubiquitinates ROBO3.1 (Homo sapiens)
RHEA:35770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosterigmatocystin + S-adenosyl-L-methionine <=> 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine
RHEA:37901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate => 2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2
REACT:R-SSC-1630304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Sus scrofa)
REACT:R-GGA-2132060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C5b:C6:C7 (Gallus gallus)
REACT:R-XTR-212713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLC-gamma1 dissociates from EGFR (Xenopus tropicalis)
REACT:R-BTA-8982165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Bos taurus)
RHEA:51930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH => H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+)
RHEA:35436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose => cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP
REACT:R-XTR-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Xenopus tropicalis)
RHEA:20293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diiodophenylpyruvate reductase"
RHEA:20293	skos:prefLabel	"diiodophenylpyruvate reductase"
RHEA:20293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH
REACT:R-SSC-9731661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Sus scrofa)
REACT:R-DDI-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)
REACT:R-MMU-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Mus musculus)
REACT:R-HSA-9698005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 ITD mutants phosphorylate STAT5 (Homo sapiens)
REACT:R-HSA-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Homo sapiens)
REACT:R-CFA-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Canis familiaris)
REACT:R-BTA-5624129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LZTFL1 binds the BBSome and prevents its traffic to the cilium (Bos taurus)
REACT:R-HSA-9673223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIX(29-461) variant is not activated (factor XIa catalyst) (Homo sapiens)
RHEA:16973	skos:altLabel	"2-Hydroxypyridine oxygenase"
RHEA:16973	skos:prefLabel	"2-hydroxypyridine 5-monooxygenase"
RHEA:16973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxypyridine + AH2 + O2 = 2,5-dihydroxypyridine + A + H2O
RHEA:16973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxypyridine 5-monooxygenase"
GO:0033971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HIUHase activity
GO:0033971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyisourate hydrolase activity
GO:0033971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-hydroxyisourate hydrolase activity
GO:0033971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-hydroxyisourate amidohydrolase activity
REACT:R-HSA-9011143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO3.1 expression is stimulated by LHX2,(LHX9) (Homo sapiens)
REACT:R-XTR-5674019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds KSR1:MARK3 (Xenopus tropicalis)
GO:0030251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanylate cyclase inhibitor activity
RHEA:24840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine
RHEA:24840	skos:prefLabel	"phosphomethylpyrimidine synthase"
RHEA:24840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphomethylpyrimidine synthase"
RHEA:35182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA <=> 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone
RHEA:41733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + phosphate => [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
REACT:R-HSA-6784324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)
RHEA:58542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-dodecanoylglycine + O2
GO:0035716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine (C-C motif) ligand 12 binding
GO:0035716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCL12 binding
RHEA:23454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dAMP + H(+) => 2'-deoxyadenosine + ATP
REACT:R-CFA-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Canis familiaris)
RHEA:63720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D-glucuronide + UDP
REACT:R-CFA-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Canis familiaris)
RHEA:60786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A25 + H(+) + succinate => 2-oxoglutarate + gibberellin A24 + O2
REACT:R-RNO-5577237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNH2:KCNE transport K+ from cytosol to extracellular region (Rattus norvegicus)
RHEA:19781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diiodotyrosine transaminase"
RHEA:19781	skos:altLabel	"diiodotyrosine aminotransferase"
RHEA:19781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate
RHEA:19781	skos:prefLabel	"diiodotyrosine transaminase"
RHEA:54674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-kolavelool + diphosphate => (+)-kolavenyl diphosphate + H2O
REACT:R-BTA-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Bos taurus)
RHEA:66707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mycophenolyl-CoA <=> CoA + H(+) + mycophenolate
REACT:R-CFA-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Canis familiaris)
REACT:R-RNO-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Rattus norvegicus)
RHEA:45904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + epivancomycin + H(+)
REACT:R-MMU-8864105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 binds ERBB2:EGFR heterodimers (Mus musculus)
RHEA:65308	skos:altLabel	"beta-ketoacyl-acyl carrier protein synthase KasB"
RHEA:65308	skos:prefLabel	"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II"
RHEA:65308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II"
RHEA:65308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]
RHEA:62886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (M)-viriditoxin + 2 H2O => O2 + 4 semiviriditoxin
RHEA:16013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine--tRNA ligase"
RHEA:16013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
RHEA:16013	skos:prefLabel	"glycine--tRNA ligase"
RHEA:16013	skos:altLabel	"glycyl-tRNA synthetase"
RHEA:16013	skos:altLabel	"glycyl translase"
REACT:R-DRE-4084505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins bind HSPG2 (Danio rerio)
GO:0016805	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytosolic dipeptidase activity
GO:0016805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dipeptidase activity
REACT:R-HSA-210430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of L-Glutamate at the synapse (Homo sapiens)
GO:0008579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JUN kinase phosphatase activity
RHEA:40952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetamido-4-aminobutanoate + H2O => acetate + L-2,4-diaminobutanoate
REACT:R-HSA-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Homo sapiens)
REACT:R-CFA-1236398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds NRGs or EGF-like ligands (Canis familiaris)
REACT:R-SCE-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Saccharomyces cerevisiae)
RHEA:21461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoin => 2 benzaldehyde
GO:0086008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
REACT:R-MMU-5668718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)
GO:0015452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methyltransfer-driven transporters
GO:0015452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl transfer-driven active transmembrane transporter activity
RHEA:63567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apelin-13 + H2O <=> apelin-12 + L-phenylalanine
RHEA:38726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol
RHEA:25352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinyl-tRNA(Pro) => H(+) + L-cysteine + tRNA(Pro)
RHEA:21712	skos:altLabel	"L-threo-3-phenylserine benzaldehyde-lyase"
RHEA:21712	skos:prefLabel	"phenylserine aldolase"
RHEA:21712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-3-phenylserine = benzaldehyde + glycine
RHEA:21712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylserine aldolase"
REACT:R-XTR-169719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted CD14 binds LPS (Xenopus tropicalis)
RHEA:63874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3(1)-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2
REACT:R-CFA-5667008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds RHPN1 or RHPN2 (Canis familiaris)
REACT:R-XTR-5340214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB binds O2 (Xenopus tropicalis)
RHEA:72543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) = 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)
RHEA:51448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Rattus norvegicus)
REACT:R-DME-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Drosophila melanogaster)
RHEA:20385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + H(+) + NADH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)
RHEA:11138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate
GO:0047071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
GO:0047071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)
GO:0047071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alkylcatechol 2,3-dioxygenase activity
GO:0047071	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid 4,5-dioxygenase activity
REACT:R-MMU-6804229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMY, TTC5 and EP300 bind (Mus musculus)
RHEA:23468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-aminobenzenesulfonate 2,3-dioxygenase"
RHEA:23468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzenesulfonate + 2 H(+) + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)
RHEA:23468	skos:altLabel	"2-aminosulfobenzene 2,3-dioxygenase"
RHEA:23468	skos:prefLabel	"2-aminobenzenesulfonate 2,3-dioxygenase"
RHEA:44951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)
RHEA:26437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole + L-serine <=> H2O + L-tryptophan
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha(17beta)-HSD
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone 17b-dehydrogenase activity
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	testosterone 17beta-dehydrogenase activity
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone 17-beta-dehydrogenase (NAD+) activity
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	17-ketoreductase activity
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	17-beta-HSD activity
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone dehydrogenase (NAD+) activity
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17beta-HSD
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha,17beta-hydroxy steroid dehydrogenase activity
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
GO:0047035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity
REACT:R-XTR-443439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-Src binds Raf1 (Xenopus tropicalis)
REACT:R-SSC-5213466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is phosphorylated (Sus scrofa)
REACT:R-CFA-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Canis familiaris)
REACT:R-CFA-3322422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits SMARCA4 (Canis familiaris)
REACT:R-HSA-1678843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein translation regulator 4EHP (Homo sapiens)
RHEA:45449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(dodecanoyl)-sphinganine => dodecanoate + sphinganine
REACT:R-RNO-2730849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)
GO:0047875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ecdysone oxidase activity
GO:0047875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone oxidase activity
GO:0047875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ecdysone:oxygen 3-oxidoreductase activity
RHEA:49772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoylglycine
REACT:R-HSA-428918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:G13 complex (Homo sapiens)
REACT:R-SSC-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Sus scrofa)
REACT:R-SSC-2424477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS mediated nucleotide exchange of RAS (SHC) (Sus scrofa)
RHEA:22096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polyribonucleotide nucleotidyltransferase"
RHEA:22096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)
RHEA:22096	skos:altLabel	"polynucleotide phosphorylase"
RHEA:22096	skos:prefLabel	"polyribonucleotide nucleotidyltransferase"
REACT:R-MMU-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Mus musculus)
REACT:R-BTA-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Bos taurus)
REACT:R-RNO-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Rattus norvegicus)
REACT:R-HSA-211715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of PAK-2p34 (Homo sapiens)
RHEA:62457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-glutamate => diphosphate + L-glutamyl-5'-AMP
RHEA:39871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-DME-8852874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 binds C3d, C3dg, iC3b (Drosophila melanogaster)
REACT:R-GGA-1861621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIA with IgG-coated Ag (Gallus gallus)
REACT:R-HSA-381466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Homo sapiens)
REACT:R-GGA-5689085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds polyUb-PARK2 (Gallus gallus)
REACT:R-CEL-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Caenorhabditis elegans)
REACT:R-DRE-749446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Danio rerio)
RHEA:64242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octanoylglycine => glycine + octanoyl-CoA
RHEA:30883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucurono-3,6-lactone + 2 H2O + NAD(+) = D-glucarate + 3 H(+) + NADH
RHEA:50488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]
REACT:R-CFA-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Canis familiaris)
RHEA:54577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 => an adenosine in tRNA + CO2 + formaldehyde + succinate
RHEA:34432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-secoisolariciresinol + NADP(+) => (-)-lariciresinol + H(+) + NADPH
EC:3.4.17.18	skos:prefLabel	"carboxypeptidase T"
EC:3.4.17.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxypeptidase T"
REACT:R-HSA-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Homo sapiens)
REACT:R-HSA-3149563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Homo sapiens)
REACT:R-GGA-5696872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates Ub-MOM proteins (Gallus gallus)
REACT:R-SSC-9013110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC binds effectors at the plasma membrane (Sus scrofa)
RHEA:63058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine
REACT:R-HSA-9625346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBF1 gene expression is inhibited by FOXO1 (Homo sapiens)
RHEA:45827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine <=> CO2 + ethanolamine
RHEA:30847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + glutaryl-CoA + 2 H(+) = (2E)-butenoyl-CoA + CO2 + FADH2
RHEA:71991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate = (-)-astellatene + diphosphate
REACT:R-XTR-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Xenopus tropicalis)
GO:0046975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-methyltransferase activity (H3-K36 specific)
GO:0046975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3K36 methyltransferase activity
GO:0046975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36 methylase activity
GO:0046975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H3-K36 specific)
GO:0046975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-K36 specific)
GO:0046975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36 methyltransferase activity
RHEA:70083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyclavatol = H2O + o-quinone methide
REACT:R-DDI-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Dictyostelium discoideum)
RHEA:66880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)
RHEA:35415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose = an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP
RHEA:35415	skos:prefLabel	"anthocyanin 3-O-sambubioside 5-O-glucosyltransferase"
RHEA:35415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanin 3-O-sambubioside 5-O-glucosyltransferase"
RHEA:61402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine => ATP + N(6)-(D-ribulosyl)-L-lysine
REACT:R-XTR-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Xenopus tropicalis)
GO:0015089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity copper ion transmembrane transporter activity
GO:0015089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity copper transporter activity
GO:0015089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity copper ion transmembrane transporter activity
REACT:R-DRE-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Danio rerio)
RHEA:42596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2
REACT:R-GGA-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
REACT:R-HSA-192335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Homo sapiens)
RHEA:67054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + asnovolin A + H2O => AH2 + asnovolin J + O2
REACT:R-DRE-751027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Danio rerio)
REACT:R-SCE-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Saccharomyces cerevisiae)
RHEA:26269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-2 + 3 H(+) = Co(2+) + precorrin-2
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid aminotransferase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-succinic semialdehyde transaminase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate transaminase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA transaminase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid transaminase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyrate aminotransaminase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyrate transaminase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyric acid aminotransferase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminobutyrate aminotransferase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA aminotransferase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-amino-N-butyrate transaminase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyrate aminotransferase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-alanine aminotransferase
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminobutyrate transaminase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA transferase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyrate transaminase activity
GO:0003867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric transaminase activity
RHEA:57715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP
REACT:R-DRE-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Danio rerio)
RHEA:62011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)
REACT:R-DRE-168400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iE-DAP elicits a NOD1 response (Danio rerio)
RHEA:63495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menadione + NADPH <=> menadiol + NADP(+)
REACT:R-SSC-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Sus scrofa)
REACT:R-DRE-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Danio rerio)
RHEA:34460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycopalyl diphosphate + H2O => diphosphate + sclareol
REACT:R-HSA-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Homo sapiens)
RHEA:57933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate
RHEA:43349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z-octadecenoate)(in) => cholesteryl (9Z-octadecenoate)(out)
RHEA:45656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-MMU-175983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfer CH3 from AdoMet to 3,4DHBNZ (Mus musculus)
RHEA:11727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite <=> 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol
RHEA:46511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + nitrobenzene + O2 <=> catechol + NAD(+) + nitrite
REACT:R-CFA-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
REACT:R-HSA-9626816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds p-S345-NCF1 (Homo sapiens)
REACT:R-DRE-2530453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vitronectin (VTN) binds to C5b:C6:C7 (Danio rerio)
REACT:R-RNO-3222020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUAK1 phosphorylates TP53 (Rattus norvegicus)
RHEA:27775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:42448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-2-hydroxyglutaryl-CoA dehydratase"
RHEA:42448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O
RHEA:42448	skos:prefLabel	"(R)-2-hydroxyglutaryl-CoA dehydratase"
RHEA:61325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Dictyostelium discoideum)
GO:0052880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a copper protein as acceptor"
GO:0052880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor
GO:0052880	skos:prefLabel	"With a copper protein as acceptor"
RHEA:13659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + H2O
GO:0031695	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-2B adrenergic receptor ligand
GO:0031695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2B adrenergic receptor binding
REACT:R-DME-8941628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)
REACT:R-MMU-170126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin B1 in the CRS domain (Mus musculus)
REACT:R-HSA-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Homo sapiens)
RHEA:52329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + O2 + reduced [flavodoxin] => H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]
REACT:R-XTR-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Xenopus tropicalis)
REACT:R-BTA-1562641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
RHEA:14993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)
RHEA:14993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty-acid synthase system"
RHEA:14993	skos:altLabel	"fatty-acid synthase"
RHEA:14993	skos:prefLabel	"fatty-acid synthase system"
RHEA:37242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-UMP + H2O <=> H(+) + uridine 2'-phosphate
RHEA:29458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(in) <=> D-serine(out)
REACT:R-GGA-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Gallus gallus)
REACT:R-RNO-180038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Rattus norvegicus)
RHEA:38390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)
RHEA:17093	skos:prefLabel	"phosphatidylinositol diacylglycerol-lyase"
RHEA:17093	skos:altLabel	"monophosphatidylinositol phosphodiesterase"
RHEA:17093	skos:altLabel	"1-phosphatidylinositol phosphodiesterase"
RHEA:17093	skos:altLabel	"phosphatidylinositol phospholipase C"
RHEA:17093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol
RHEA:17093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol diacylglycerol-lyase"
RHEA:38571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
REACT:R-HSA-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Homo sapiens)
REACT:R-DRE-5621353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Danio rerio)
REACT:R-SSC-8873794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCTP binds PC (Sus scrofa)
RHEA:32125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + H(+)(out) => citrate(in) + H(+)(in)
REACT:R-RNO-444202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR1 binds free fatty acids (Rattus norvegicus)
GO:0045129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AcuC
GO:0045129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-independent histone deacetylase activity
REACT:R-RNO-1971482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Rattus norvegicus)
REACT:R-HSA-9635667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esxG:esxH binds HGS (Homo sapiens)
REACT:R-CEL-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Caenorhabditis elegans)
REACT:R-XTR-202731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM3 dimerises (Xenopus tropicalis)
RHEA:54869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-[ACP] + H(+) + NADH => butanoyl-[ACP] + NAD(+)
REACT:R-CFA-6797568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind CASK:Protein 4.1 (Canis familiaris)
REACT:R-HSA-5654591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
GO:0018608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-indanone dioxygenase activity
REACT:R-RNO-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Rattus norvegicus)
REACT:R-MMU-8851550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside diphosphates (Mus musculus)
REACT:R-CFA-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Canis familiaris)
RHEA:32265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + succinate semialdehyde => 4-aminobutanoate + pyruvate
RHEA:23310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-[(E)-sinapoyl]-D-glucarate + CoA => (E)-sinapoyl-CoA + D-glucarate
GO:0033851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity
GO:0033851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FDS-5
GO:0033851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lavandulyl diphosphate synthase activity
RHEA:48707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 12S-HpEPE
REACT:R-RNO-3000434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Rattus norvegicus)
REACT:R-CEL-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Caenorhabditis elegans)
REACT:R-SCE-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Saccharomyces cerevisiae)
GO:0102186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity
REACT:R-SSC-433711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-homodimerization of nectins (Sus scrofa)
EC:4.99.1.-	skos:prefLabel	"Other lyases"
EC:4.99.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other lyases"
REACT:R-XTR-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Xenopus tropicalis)
RHEA:68033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cystathionine ketimine + 2 H(+) + NADH => (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)
GO:0015183	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-aspartate transporter activity
GO:0015183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate transmembrane transporter activity
GO:0015183	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glutamate/aspartate porter activity
GO:0015183	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glutamate/aspartate:sodium symporter activity
REACT:R-RNO-9632039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)
REACT:R-XTR-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Xenopus tropicalis)
RHEA:17691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycochenodeoxycholate
REACT:R-XTR-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Xenopus tropicalis)
RHEA:43365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose => beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP
RHEA:46694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-5'-AMP + diphosphate => 4-hydroxybenzoate + ATP + H(+)
RHEA:24269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dioxo-6-phenylhexanoate + NADP(+) => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH
REACT:R-HSA-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)
RHEA:11960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinyldiaminopimelate transaminase"
RHEA:11960	skos:altLabel	"succinyldiaminopimelate aminotransferase"
RHEA:11960	skos:altLabel	"succinyldiaminopimelate transferase"
RHEA:11960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate
RHEA:11960	skos:prefLabel	"succinyldiaminopimelate transaminase"
RHEA:47301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:59656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotriose + O2 = D-cellotriono-1,5-lactone + H2O2
GO:0001181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase I general transcription initiation factor activity
GO:0001181	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transcription factor activity, core RNA polymerase I binding
GO:0001181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase I transcription general initiation factor activity
GO:0001181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	general RNA polymerase I transcription factor activity
GO:0001181	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core RNA polymerase I binding transcription factor activity
REACT:R-XTR-5357479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AXL binds PI3K (Xenopus tropicalis)
REACT:R-HSA-2187264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet glycoprotein IV (CD36) binds ligands (Homo sapiens)
RHEA:22108	skos:altLabel	"L-threonine deaminase"
RHEA:22108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine = 2-oxobutanoate + NH4(+)
RHEA:22108	skos:altLabel	"threonine dehydratase"
RHEA:22108	skos:altLabel	"serine deaminase"
RHEA:22108	skos:altLabel	"L-threonine hydro-lyase (deaminating)"
RHEA:22108	skos:altLabel	"L-serine dehydratase"
RHEA:22108	skos:altLabel	"L-threonine dehydratase"
RHEA:22108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"threonine ammonia-lyase"
RHEA:22108	skos:prefLabel	"threonine ammonia-lyase"
RHEA:22108	skos:altLabel	"threonine deaminase"
RHEA:22108	skos:altLabel	"threonine dehydrase"
RHEA:14713	skos:prefLabel	"sorbose dehydrogenase"
RHEA:14713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sorbose dehydrogenase"
RHEA:14713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + keto-L-sorbose = 5-dehydro-D-fructose + AH2
RHEA:40797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine
RHEA:56775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-adonixanthin + 2 O2 <=> 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O
REACT:R-GGA-8848316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36 binds IL1RL2 (Gallus gallus)
RHEA:69276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate = but-3-enenitrile + sulfate + sulfur
REACT:R-SSC-8875817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates STAT3 (Sus scrofa)
RHEA:23686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:67752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-HSA-3165230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC52A1,2,3 transport RIB from extracellular region to cytosol (Homo sapiens)
RHEA:52199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Drosophila melanogaster)
RHEA:57168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2
REACT:R-DRE-1370500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR binds SCF beta-TrCP complex (Danio rerio)
REACT:R-HSA-184392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of GAG polyprotein by NMT2 (Homo sapiens)
REACT:R-BTA-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Bos taurus)
RHEA:71538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate(in) + phosphate(out) <=> D-glucose 6-phosphate(out) + phosphate(in)
RHEA:28543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetyl-CoA + H2O => CoA + fluoroacetate + H(+)
REACT:R-CFA-9696275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds GTP (Canis familiaris)
RHEA:60746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + pyrethrin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone
REACT:R-XTR-380283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Xenopus tropicalis)
REACT:R-DRE-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Danio rerio)
RHEA:47562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GM1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E))
RHEA:37176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA
GO:0097261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXA4 is converted to EXC4 by LTC4S (Homo sapiens)
GO:0097261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eoxin C4 synthase activity
RHEA:57192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein]
RHEA:32756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + 2-oxoglutarate + O2 => apigenin + CO2 + H(+) + H2O + succinate
REACT:R-SSC-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Sus scrofa)
RHEA:14492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 2'-phosphate + H(+)
REACT:R-GGA-1227891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3/or TRAF6 interacts with IPS-1 (Gallus gallus)
REACT:R-SSC-749456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)
REACT:R-BTA-8951498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Bos taurus)
RHEA:18350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + tRNA(Asx) => AMP + diphosphate + L-aspartyl-tRNA(Asx)
RHEA:23556	skos:prefLabel	"D-alanine gamma-glutamyltransferase"
RHEA:23556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-alanine gamma-glutamyltransferase"
RHEA:23556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4(+)
RHEA:28715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate(in) + 2 H(+)(in) = (R)-malate(out) + 2 H(+)(out)
REACT:R-HSA-2038387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants (Homo sapiens)
REACT:R-DME-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Drosophila melanogaster)
REACT:R-RNO-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Rattus norvegicus)
RHEA:59005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + H2O + O2 => dodecanoate + H(+) + H2O2
REACT:R-DRE-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Danio rerio)
REACT:R-CFA-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Canis familiaris)
RHEA:45272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)-octadecenoate + phosphate
REACT:R-XTR-1067659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of hexameric IL-6 receptor (Xenopus tropicalis)
REACT:R-CEL-3781024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Caenorhabditis elegans)
REACT:R-SSC-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Sus scrofa)
GO:0050197	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytanoyl-CoA ligase activity
GO:0050197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate-CoA ligase activity
GO:0050197	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytanate:CoA ligase (AMP-forming)
GO:0044325	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ion channel binding
GO:0044325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane transporter binding
RHEA:68816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate
RHEA:20564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + H(+) <=> CO2 + glycolaldehyde
RHEA:61799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP <=> AMP + L-tryptophyl-[peptidyl-carrier protein]
RHEA:55114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+) => 4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH
RHEA:65435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)
RHEA:61591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amicoumacin A + ATP <=> ADP + amicoumacin A 2-phosphate + H(+)
REACT:R-MMU-9653503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B is phosphorylated on serine 181 (Mus musculus)
REACT:R-SPO-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)
REACT:R-RNO-163741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Rattus norvegicus)
REACT:R-SSC-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Sus scrofa)
RHEA:48442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
RHEA:60203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate
GO:0080002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:4-aminobenzoate acylglucosyltransferase activity
GO:0080002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:p-aminobenzoate glucosyltransferase activity
GO:0080002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:pABA acylglucosyltransferase activity
GO:0080002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:p-aminobenzoate acylglucosyltransferase activity
REACT:R-DME-538900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PER rebinds to phosphorylated TIM (Drosophila melanogaster)
REACT:R-BTA-8874705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Bos taurus)
REACT:R-CFA-9706293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CBL (Canis familiaris)
RHEA:50827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate
REACT:R-CFA-110232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by MBD4 glycosylase (Canis familiaris)
RHEA:38077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA
RHEA:70978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine(out) + L-aspartate(in) <=> 3-sulfino-L-alanine(in) + L-aspartate(out)
RHEA:46488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)
RHEA:18801	skos:prefLabel	"rubber cis-polyprenylcistransferase"
RHEA:18801	skos:altLabel	"rubber transferase"
RHEA:18801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(cis-prenyl)n-diphosphate + isopentenyl diphosphate = (cis-prenyl)(n+1)-diphosphate + diphosphate
RHEA:18801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rubber cis-polyprenylcistransferase"
RHEA:18801	skos:altLabel	"rubber allyltransferase"
REACT:R-HSA-9014456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOG (Homo sapiens)
REACT:R-SSC-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Sus scrofa)
RHEA:63820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + petrobactin
RHEA:13506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + O2 => betaine aldehyde + H2O2
REACT:R-BTA-418091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB1 (Bos taurus)
REACT:R-HSA-5633414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes (Homo sapiens)
REACT:R-XTR-5687090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6 phosphorylates NCOA3 (Xenopus tropicalis)
RHEA:65401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + butanoyl-CoA => butyl butanoate + CoA
REACT:R-CFA-5672969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF (Canis familiaris)
REACT:R-BTA-163090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation Of The Telomeric Chromosome End (Bos taurus)
RHEA:18482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexylsulfamate + H2O => cyclohexylamine + sulfate
REACT:R-HSA-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Homo sapiens)
RHEA:40548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Drosophila melanogaster)
RHEA:35713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + succinate => acetate + succinyl-CoA
REACT:R-DME-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)
RHEA:44473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine
REACT:R-DME-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Drosophila melanogaster)
REACT:R-DRE-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Danio rerio)
REACT:R-BTA-8948832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 polyubiquitinates PARylated PTEN (Bos taurus)
REACT:R-SSC-202713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD84 homodimerises (Sus scrofa)
REACT:R-DME-382052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130Cas and C3G bind PDGFR bound Crk (Drosophila melanogaster)
REACT:R-MMU-5675431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates RAF1 (Mus musculus)
GO:0043803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	demethylspheroidene O-methyltransferase
GO:0043803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-hydroxycarotenoid O-methylase
GO:0043803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-HO-carotenoid methylase
GO:0043803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyneurosporene-O-methyltransferase activity
GO:0043803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-hydroxycarotenoid methylase
REACT:R-HSA-1299480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Precursor proteins enter TIMM23 PAM (Homo sapiens)
REACT:R-BTA-419002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Bos taurus)
RHEA:35589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + riboflavin => FMN + H2O
REACT:R-SSC-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Sus scrofa)
RHEA:38105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-galactonate + H2O => L-galactonate
REACT:R-HSA-8869438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of clathrin-associated proteins (Homo sapiens)
REACT:R-RNO-3000120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLIF binds RCbl (Rattus norvegicus)
REACT:R-MMU-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Mus musculus)
REACT:R-HSA-8851899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens)
REACT:R-GGA-74948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates p-RHO to RHO (Gallus gallus)
RHEA:43651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + CoA
REACT:R-BTA-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Bos taurus)
REACT:R-MMU-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Mus musculus)
REACT:R-DME-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Drosophila melanogaster)
RHEA:57957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + H(+) + NADH + O2 => dimethyl sulfone + H2O + NAD(+)
RHEA:11873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]
RHEA:66611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O <=> GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)
REACT:R-CEL-8953013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 binds E2F8 (Caenorhabditis elegans)
GO:0018469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myrtenal dehydrogenase activity
REACT:R-GGA-1067688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)
RHEA:63339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xylose <=> beta-D-xylose
REACT:R-DME-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Drosophila melanogaster)
RHEA:18408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanine + NAD(+) <=> H(+) + NADH + NH4(+) + pyruvate
RHEA:66480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenin + UDP-alpha-D-glucose = gypsogenin 28-beta-D-glucoside + UDP
RHEA:42532	skos:altLabel	"Psi(55) synthase"
RHEA:42532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(55) in tRNA = pseudouridine(55) in tRNA
RHEA:42532	skos:prefLabel	"tRNA pseudouridine(55) synthase"
RHEA:42532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA pseudouridine(55) synthase"
RHEA:42532	skos:altLabel	"tRNA pseudouridine 55 synthase"
RHEA:42532	skos:altLabel	"Psi(55) tRNA pseudouridine synthase"
RHEA:42532	skos:altLabel	"tRNA Psi(55) synthase"
REACT:R-DRE-77254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Danio rerio)
RHEA:61262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate + H2O2 + NH4(+) => H2O + L-glutamine + O2
RHEA:14884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) <=> asparagusate + H(+) + NADH
REACT:R-BTA-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Bos taurus)
REACT:R-DRE-6786072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3,p-Y641-STAT6 dissociate (Danio rerio)
RHEA:40065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O
RHEA:22436	skos:prefLabel	"germacradienol synthase"
RHEA:22436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate
RHEA:22436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"germacradienol synthase"
RHEA:22436	skos:altLabel	"germacradienol/germacrene-D synthase"
REACT:R-DRE-176116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of Chk1 (Danio rerio)
EC:2.5.1.149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lycopene elongase/hydratase (flavuxanthin-forming)"
EC:2.5.1.149	skos:prefLabel	"lycopene elongase/hydratase (flavuxanthin-forming)"
RHEA:54724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
GO:0072544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-DOPA binding
RHEA:47505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
RHEA:39219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctacosanyol-CoA + H(+) + NADPH = (3R)-hydroxyoctacosanoyl-CoA + NADP(+)
RHEA:59976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + H(+) = CO2 + toluene
RHEA:59976	skos:prefLabel	"phenylacetate decarboxylase"
RHEA:59976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetate decarboxylase"
REACT:R-MMU-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)
GO:0102992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutyronitrile hydroxylase activity
RHEA:21807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + myo-inositol <=> 1D-myo-inositol 3-phosphate + ADP + H(+)
RHEA:17100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate <=> enol-phenylpyruvate
REACT:R-CFA-5654605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS3 (Canis familiaris)
RHEA:22651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[cytochrome c] <=> apo-[cytochrome c] + heme b
RHEA:59617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-L-arginine + H2O => beta-alanine + L-arginine
GO:0106407	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Glucosidase II
GO:0106407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc2Man9GlcNAc2 oligosaccharide glucosidase activity
REACT:R-HSA-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Homo sapiens)
REACT:R-DME-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Drosophila melanogaster)
REACT:R-DME-1168643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCP ubiquitinylates IkB (Drosophila melanogaster)
REACT:R-MMU-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Mus musculus)
RHEA:41273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O
REACT:R-HSA-480301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of EPAS1 (HIF2A) (Homo sapiens)
GO:0047610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspirin esterase activity
GO:0047610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylsalicylate deacetylase activity
GO:0047610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspirin hydrolase activity
GO:0047610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylsalicylate O-acetylhydrolase activity
GO:0047610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylsalicylic acid esterase activity
REACT:R-MMU-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Mus musculus)
REACT:R-HSA-1462039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-HNP1-4 are cleaved to biologically active defensin (Homo sapiens)
REACT:R-MMU-5607733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 binds CARD9 (Mus musculus)
RHEA:38060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA => 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-BTA-6786048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Bos taurus)
REACT:R-DME-209177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGS:ARM complex transports from the cytosol to the nucleus (Drosophila melanogaster)
REACT:R-DME-8948018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Drosophila melanogaster)
REACT:R-GGA-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Gallus gallus)
REACT:R-DME-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)
REACT:R-GGA-5649681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL2 cleaves 5-OHU from damaged DNA (Gallus gallus)
RHEA:28225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + ATP <=> 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)
REACT:R-CFA-428518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glypican-1 (GPC1) binds SLIT2 (Canis familiaris)
REACT:R-GGA-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Gallus gallus)
RHEA:15868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + tryptamine <=> 4-hydroxytryptamine + A + H2O
RHEA:71508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-tocopherol(out) => (+)-alpha-tocopherol(in)
REACT:R-BTA-5610733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Bos taurus)
REACT:R-RNO-3215406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds WDR77 (Rattus norvegicus)
RHEA:58116	skos:prefLabel	"EGF-domain serine glucosyltransferase"
RHEA:58116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:58116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"EGF-domain serine glucosyltransferase"
REACT:R-DRE-5591040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves Factor Va intermediate form for Factor Va (Danio rerio)
RHEA:44206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 2-hydroxyhexadecanoate + ATP + CoA
REACT:R-DME-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Drosophila melanogaster)
RHEA:20102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + L-cysteinyl-[protein] => AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]
REACT:R-SPO-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Schizosaccharomyces pombe)
RHEA:41092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine
RHEA:49544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O = 2-dehydro-3-deoxy-D-gluconate + NH4(+)
REACT:R-RNO-870449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 monoubiquitinates SMAD4 (Rattus norvegicus)
RHEA:46684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-24-oyl-CoA + A = (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2
REACT:R-SCE-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Saccharomyces cerevisiae)
REACT:R-HSA-179467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)
RHEA:12681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine + H(+) + H2O = N-methylhydantoin + NH4(+)
RHEA:12681	skos:prefLabel	"creatinine deaminase"
RHEA:12681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"creatinine deaminase"
REACT:R-RNO-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:14273	skos:prefLabel	"spermidine dehydrogenase"
RHEA:14273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spermidine dehydrogenase"
RHEA:14273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + spermidine = 4-aminobutanal + AH2 + propane-1,3-diamine
RHEA:46818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:0031781	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 3 melanocortin receptor ligand
GO:0031781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 3 melanocortin receptor binding
REACT:R-SSC-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Sus scrofa)
REACT:R-DRE-5690759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Danio rerio)
RHEA:43463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA
REACT:R-RNO-190268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to Klotho-bound FGF23 (Rattus norvegicus)
REACT:R-SPO-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)
RHEA:37542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
RHEA:15043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inulobiose => bis-D-fructose 2',1:2,1'-dianhydride + H2O
GO:0140825	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	peroxidase activity
GO:0140825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactoperoxidase activity
GO:0102419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-2-glycerol-3-phosphate omega-OH-C22:0-CoA acyl transferase activity
REACT:R-MMU-8848774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds DOK1 (Mus musculus)
REACT:R-DRE-198609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates TSC2, inhibiting it (Danio rerio)
RHEA:14645	skos:altLabel	"S-adenosylmethionine cleaving enzyme"
RHEA:14645	skos:altLabel	"S-adenosylmethionine hydrolase"
RHEA:14645	skos:prefLabel	"S-adenosyl-L-methionine hydrolase (L-homoserine-forming)"
RHEA:14645	skos:altLabel	"methylmethionine-sulfonium-salt hydrolase"
RHEA:14645	skos:altLabel	"S-adenosyl-L-methionine hydrolase"
RHEA:14645	skos:altLabel	"adenosylmethionine hydrolase"
RHEA:14645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-adenosyl-L-methionine = H(+) + L-homoserine + S-methyl-5'-thioadenosine
RHEA:14645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-adenosyl-L-methionine hydrolase (L-homoserine-forming)"
RHEA:52659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) <=> a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH
REACT:R-GGA-8987043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22RA1 binds JAK1 (Gallus gallus)
RHEA:43848	skos:prefLabel	"arsenate reductase (thioredoxin)"
RHEA:43848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arsenate reductase (thioredoxin)"
RHEA:43848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + arsenate + H(+) = [thioredoxin]-disulfide + arsenite + H2O
REACT:R-DME-450490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B/Akt phosphorylates BRF1 (Drosophila melanogaster)
RHEA:41047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA
REACT:R-RNO-159795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Rattus norvegicus)
REACT:R-DME-9611852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB3 bind ADR,NAd (Drosophila melanogaster)
REACT:R-GGA-445064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by VAV2 (Gallus gallus)
REACT:R-SSC-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Sus scrofa)
REACT:R-MMU-354087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2 to p-PTK2 (Mus musculus)
EC:2.3.1.45	skos:prefLabel	"N-acetylneuraminate 7-O(or 9-O)-acetyltransferase"
EC:2.3.1.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylneuraminate 7-O(or 9-O)-acetyltransferase"
REACT:R-XTR-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Xenopus tropicalis)
REACT:R-SSC-8851842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUC20 binds MET and inhibits GRB2 binding (Sus scrofa)
RHEA:11097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADPH
RHEA:59213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP => AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]
REACT:R-HSA-9036285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
RHEA:50675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose
REACT:R-MMU-9010815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLITs bind keratan sulfate (Mus musculus)
REACT:R-GGA-2029272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of PLCG from FCGR (Gallus gallus)
REACT:R-SSC-4641253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 ubiquitinates FZD to promote its downregulation (Sus scrofa)
REACT:R-GGA-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Gallus gallus)
REACT:R-XTR-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Xenopus tropicalis)
REACT:R-HSA-9036050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SGSH does not hydrolyse Heparan sulfate chain(2) (Homo sapiens)
RHEA:12368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH2
RHEA:12368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dehydrogluconate dehydrogenase"
RHEA:12368	skos:prefLabel	"dehydrogluconate dehydrogenase"
RHEA:12368	skos:altLabel	"ketogluconate dehydrogenase"
RHEA:58270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide => [protein]-C-terminal glycine + NAD(+)
GO:0140856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone ubiquitin ligase activity (H2A-K13 specific)
GO:0140856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AK13 ubiquitin ligase activity
GO:0050520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PC synthase activity
GO:0050520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diglyceride-choline O-phosphatidyltransferase activity
GO:0050520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diacylglycerol:choline O-phosphatidyltransferase activity
GO:0050520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine synthase activity
GO:0050520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPdiglyceride-choline O-phosphatidyltransferase activity
GO:0010328	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	auxin influx facilitator
GO:0010328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	auxin influx transmembrane transporter activity
RHEA:28788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-threonine + ATP => 4-(phosphooxy)-L-threonine + ADP + H(+)
REACT:R-DRE-5610760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by ITCH (Danio rerio)
RHEA:45665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
GO:0004333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fumarase activity
GO:0004333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate hydro-lyase (fumarate-forming)
GO:0004333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-malate hydro-lyase activity
GO:0004333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate hydro-lyase activity
GO:0004333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate hydratase activity
REACT:R-BTA-9727198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)
RHEA:58266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol
GO:0080118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brassinosteroid sulfotransferase activity
REACT:R-CFA-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Canis familiaris)
REACT:R-DRE-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Danio rerio)
RHEA:60812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A12 aldehyde + O2 = CO2 + gibberellin A12 + H(+) + succinate
RHEA:48886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-divinyl protochlorophyllide a + H(+) + NADPH => NADP(+) + protochlorophyllide a
REACT:R-XTR-8936519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO2:FAD dimer reduces quinones to hydroquinones (Xenopus tropicalis)
RHEA:22019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutaredoxin]-dithiol + arsenate + glutathione + H(+) <=> arsenite + glutathionyl-S-S-[glutaredoxin] + H2O
REACT:R-RNO-9755304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUL1 ubiquitinates UBXN7 (Rattus norvegicus)
RHEA:13304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a sterol <=> a 1-acyl-sn-glycerol + a sterol ester
REACT:R-CFA-8852522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 dimer:MST1R dimer binds MST1R dimer (Canis familiaris)
REACT:R-XTR-420598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:Nectin-4 trans heterodimer formation (Xenopus tropicalis)
REACT:R-BTA-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Bos taurus)
RHEA:18644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H2 <=> a menaquinol
REACT:R-HSA-9752980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTP1S:RTP2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane (Homo sapiens)
REACT:R-PFA-351963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A18 transports Gly from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-MMU-209125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Mus musculus)
REACT:R-HSA-5617454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB1 gene is transcribed (Homo sapiens)
REACT:R-DRE-5672304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Danio rerio)
RHEA:21178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate + H(+) + NADPH => L-idonate + NADP(+)
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nPKC
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKCzeta
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKCalpha
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein kinase Cepsilon activity
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cPKCgamma
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nPKCtheta
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase C activity
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nPKCeta
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol-activated phospholipid-dependent PKC activity
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cPKCbeta
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK24
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKCdelta
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC activity
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nPKCepsilon
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cPKCalpha
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Pkc1p
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cPKC
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol-activated phospholipid-dependent protein kinase C activity
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein phosphotransferase (diacylglycerol-dependent) activity
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nPKCdelta
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKC
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKCbeta
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKCepsilon
GO:0004697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKCgamma
REACT:R-SCE-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Saccharomyces cerevisiae)
RHEA:48147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine <=> ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate
REACT:R-CFA-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Canis familiaris)
RHEA:58674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucuronate => D-glucuronate
REACT:R-HSA-418850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 (Homo sapiens)
RHEA:27390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O => pyruvate + salicylaldehyde
REACT:R-HSA-5668520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26Sproteasome degrades K48polyUb-NIK (Homo sapiens)
REACT:R-DME-5654612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
RHEA:21062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + N-(3,4-dichlorophenyl)malonamate => 3,4-dichloroaniline + malonyl-CoA
GO:0016884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0016884	skos:prefLabel	"Carbon--nitrogen ligases with glutamine as amido-N-donor"
GO:0016884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carbon--nitrogen ligases with glutamine as amido-N-donor"
RHEA:31723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal Gly-Gly + ATP + H(+) => [protein]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-SSC-9021357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCI phosphorylates ELF3 (Sus scrofa)
RHEA:47043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] <=> 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]
RHEA:14214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose 1-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)
RHEA:63312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 = 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate
REACT:R-DDI-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Dictyostelium discoideum)
REACT:R-HSA-1482773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL transports from the IM to the ER (Homo sapiens)
RHEA:22064	skos:prefLabel	"5alpha-hydroxysteroid dehydratase"
RHEA:22064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5alpha-hydroxysteroid dehydratase"
RHEA:22064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O
RHEA:48003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)
REACT:R-DME-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)
REACT:R-XTR-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Xenopus tropicalis)
RHEA:32246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,5-bisphosphate <=> D-ribulose 1,5-bisphosphate
RHEA:61144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin + UDP-beta-L-rhamnose = H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP
REACT:R-XTR-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Xenopus tropicalis)
REACT:R-DME-2318623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan binds Hyaluronan and HAPLN1 (Drosophila melanogaster)
REACT:R-GGA-353481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytosine G/T mismatch specific DNA glycosylase mediated recognition and binding of thymine opposite guanine at CpG sequences (Gallus gallus)
REACT:R-SSC-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Sus scrofa)
REACT:R-RNO-9773803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKBKB phosphorylates NF-kappa-B inhibitor  (Rattus norvegicus)
REACT:R-GGA-173723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C8 binds C5b:C6:C7 (Gallus gallus)
RHEA:53648	skos:prefLabel	"(+)-corvol ether A synthase"
RHEA:53648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate
RHEA:53648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-corvol ether A synthase"
REACT:R-MMU-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Mus musculus)
REACT:R-XTR-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Xenopus tropicalis)
REACT:R-RNO-9706293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CBL (Rattus norvegicus)
REACT:R-RNO-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Rattus norvegicus)
RHEA:28649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate => acetophenone + 2 ATP + H2O + hydrogencarbonate
REACT:R-SCE-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Saccharomyces cerevisiae)
REACT:R-BTA-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Bos taurus)
RHEA:35102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fusidate(in) + H(+)(out) <=> fusidate(out) + H(+)(in)
REACT:R-HSA-8944420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 binds the PTEN gene promoter (Homo sapiens)
RHEA:16494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 1,2-cyclic phosphate + H2O => glycerol 1-phosphate + H(+)
GO:0016827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on carbon-phosphorus bonds"
GO:0016827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid carbon-phosphorus bonds
GO:0016827	skos:prefLabel	"Acting on carbon-phosphorus bonds"
RHEA:47780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 25S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine
EC:3.1.1.14	skos:prefLabel	"chlorophyllase"
EC:3.1.1.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorophyllase"
REACT:R-CEL-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Caenorhabditis elegans)
REACT:R-MMU-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Mus musculus)
REACT:R-DME-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
RHEA:25459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-humulene
REACT:R-CEL-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
RHEA:45875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-DME-5610766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Drosophila melanogaster)
REACT:R-MMU-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Mus musculus)
REACT:R-MMU-688985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63 polyubiquitinated RIP2 associates with the TAK1 complex (Mus musculus)
RHEA:52886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADPH + nitrobenzene => H2O + N-phenylhydroxylamine + 2 NADP(+)
REACT:R-HSA-9667563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR2 bind desmopressin (Homo sapiens)
REACT:R-RNO-5661121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Rattus norvegicus)
REACT:R-CFA-177935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
REACT:R-DME-216282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated CI is degraded by the proteasome complex (Drosophila melanogaster)
RHEA:35082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	doxorubicin(in) <=> doxorubicin(out)
REACT:R-BTA-170844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 is cleaved by FURIN (Bos taurus)
RHEA:29318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + H2O <=> D-galactose + phosphate
REACT:R-SSC-177937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of EGFR by SRC kinase (Sus scrofa)
RHEA:50286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2
REACT:R-HSA-448480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22 binds IL22RA1:JAK1 receptor complex (Homo sapiens)
REACT:R-BTA-4720446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Bos taurus)
REACT:R-DRE-2395849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)
REACT:R-SSC-192137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
REACT:R-CFA-177926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of PAG by SHP2 (Canis familiaris)
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine synthase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-methyltetrahydrofolate methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate--homocysteine transmethylase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalamin-dependent methionine synthase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate--homocysteine S-methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(5)-methyltetrahydrofolate methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methyltetrahydrofolate:L-homocysteine methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydropteroylglutamate methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MetH
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin B12 methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine synthase (cobalamin-dependent) activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydropteroylglutamic methyltransferase activity
GO:0008705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrofolate methyltransferase activity
REACT:R-RNO-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Rattus norvegicus)
RHEA:31801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+) => 4-amino-5-aminomethyl-2-methylpyrimidine + H2O
RHEA:70496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + 2 Na(+)(out) => D-glucose(in) + 2 Na(+)(in)
REACT:R-MMU-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)
REACT:R-BTA-6810234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Bos taurus)
RHEA:16999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol
REACT:R-HSA-9640168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)
REACT:R-GGA-373177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ (Gallus gallus)
REACT:R-MMU-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
RHEA:38870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(516) in 16S rRNA <=> pseudouridine(516) in 16S rRNA
REACT:R-SSC-8952058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 binds RUNX3 and displaces EP300 (Sus scrofa)
RHEA:37447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetracenomycin F1 = H(+) + H2O + tetracenomycin D3
RHEA:37447	skos:prefLabel	"tetracenomycin-F1 monooxygenase"
RHEA:37447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetracenomycin-F1 monooxygenase"
RHEA:47358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic alcohol + H(+) + octanoate => an octanoate ester + H2O
REACT:R-SSC-2465938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates atROL taken up by Muller cells (Sus scrofa)
RHEA:19166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP
REACT:R-DRE-4551649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO1 (Danio rerio)
REACT:R-CFA-9020277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Canis familiaris)
RHEA:56023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)
REACT:R-CFA-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Canis familiaris)
REACT:R-DRE-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Danio rerio)
REACT:R-HSA-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Homo sapiens)
REACT:R-MMU-8855111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds PCSK9 (Mus musculus)
REACT:R-XTR-400434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds fatty acids (Xenopus tropicalis)
REACT:R-SSC-5654662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)
REACT:R-DRE-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Danio rerio)
RHEA:30237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-glutamate + NADH => H2O + L-glutamate 5-semialdehyde + NAD(+)
RHEA:18376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)
REACT:R-SSC-429767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Sus scrofa)
RHEA:24286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-L-aspartate + H(+) + NADPH => L-aspartate 4-semialdehyde + NADP(+) + phosphate
REACT:R-RNO-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Rattus norvegicus)
REACT:R-SSC-2127257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Sus scrofa)
REACT:R-DRE-8931648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Danio rerio)
REACT:R-HSA-212658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tranport of L-Glutamate (mitochondrial matrix) to cytosol (Homo sapiens)
RHEA:34011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydroepisterol + 2 H2O + NADP(+) = ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2
RHEA:20388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + H(+) + NADH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)
REACT:R-CFA-72127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal B Complex (Canis familiaris)
RHEA:31455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + reduced riboflavin = 2 H(+) + NADH + riboflavin
REACT:R-MMU-437118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI stimulates PI3K beta, gamma (Mus musculus)
REACT:R-SCE-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)
RHEA:43396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)
REACT:R-BTA-416683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA3E binds to PLXND1 (Bos taurus)
RHEA:47666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+)
REACT:R-DDI-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Dictyostelium discoideum)
GO:0000295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine nucleotide transmembrane transporter activity
GO:0000295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Homo sapiens)
GO:0099581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential
GO:0099581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
GO:0099581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
REACT:R-DME-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Drosophila melanogaster)
REACT:R-RNO-174171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A with the APC/C (Rattus norvegicus)
REACT:R-RNO-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Rattus norvegicus)
REACT:R-BTA-5661125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2sR4-HIST1H4 (Bos taurus)
RHEA:18872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-xylulose <=> ADP + H(+) + L-xylulose 5-phosphate
REACT:R-HSA-203712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS associates with Caveolin-1 (Homo sapiens)
GO:0004643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity
GO:0004643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoimidazolecarboxamide ribonucleotide transformylase activity
GO:0004643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity
GO:0004643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AICAR transformylase activity
GO:0004643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AICAR formyltransferase activity
GO:0004643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-amino-4-imidazolecarboxamide ribotide transformylase activity
GO:0004643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity
GO:0004643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity
GO:0004643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity
GO:0004643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosylaminoimidazolecarboxamide formyltransferase activity
REACT:R-GGA-217136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Chk1 by ATM upon DNA damage (Gallus gallus)
REACT:R-XTR-1362485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GH (Xenopus tropicalis)
RHEA:46690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2 => (25S)-3-oxocholest-4-en-26-oyl-CoA + A
GO:0140946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K4 dimethylase activity
GO:0140946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-dimethyltransferase activity (H3-K4 specific)
GO:0140946	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K4 dimethylation
GO:0140946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K4 dimethyltransferase activity
GO:0140946	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K4 dimethylation
REACT:R-HSA-418091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB1 (Homo sapiens)
REACT:R-MMU-194718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Mus musculus)
REACT:R-DME-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Drosophila melanogaster)
REACT:R-SCE-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Saccharomyces cerevisiae)
REACT:R-MMU-428231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Mus musculus)
REACT:R-BTA-211207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fragments of DFF45 dissociate from  DFF40 (Bos taurus)
RHEA:17167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + dTDP-D-galactose => alpha-D-galactose 1-phosphate + dTTP + H(+)
REACT:R-BTA-73635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Bos taurus)
REACT:R-RNO-1678920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR processing at low pH (Rattus norvegicus)
GO:0052714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-inositol phosphorylceramide phospholipase activity
REACT:R-HSA-9769302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds INS gene promoter (Homo sapiens)
REACT:R-MMU-449077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-16 is secreted (Mus musculus)
REACT:R-SPO-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)
RHEA:33496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate => 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate
RHEA:49180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d + S-adenosyl-L-methionine = a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine
RHEA:49180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacteriochlorophyllide d C-20 methyltransferase"
RHEA:49180	skos:prefLabel	"bacteriochlorophyllide d C-20 methyltransferase"
REACT:R-MMU-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Mus musculus)
REACT:R-BTA-201630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Acinus (Bos taurus)
REACT:R-RNO-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Rattus norvegicus)
RHEA:10390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + GDP + phosphoenolpyruvate => GTP + oxaloacetate
RHEA:41879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydodecanoyl-[ACP] <=> (2E)-dodecenoyl-[ACP] + H2O
REACT:R-DDI-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Dictyostelium discoideum)
REACT:R-HSA-202478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)
REACT:R-CEL-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Caenorhabditis elegans)
RHEA:51964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24244	skos:altLabel	"TR-II"
RHEA:24244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pseudotropine = H(+) + NADPH + tropinone
RHEA:24244	skos:altLabel	"tropinone reductase"
RHEA:24244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tropinone reductase II"
RHEA:24244	skos:prefLabel	"tropinone reductase II"
RHEA:24244	skos:altLabel	"pseudotropine forming tropinone reductase"
RHEA:10464	skos:prefLabel	"chitin deacetylase"
RHEA:10464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chitin deacetylase"
RHEA:10464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = n acetate + chitosan
REACT:R-RNO-442387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP8 mediates zinc influx into cells (Rattus norvegicus)
RHEA:46570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:44138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanyl dodecanoate => dodecanoyl-CoA + hexadecan-1-ol
REACT:R-SSC-5692775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Sus scrofa)
REACT:R-GGA-6798474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Zn2+ (Gallus gallus)
RHEA:12503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH
RHEA:40943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate
RHEA:59056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 methanethiol + NAD(+) = dimethyl disulfide + H(+) + NADH
RHEA:59056	skos:prefLabel	"dissimilatory dimethyldisulfide reductase"
RHEA:59056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dissimilatory dimethyldisulfide reductase"
RHEA:12557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)
REACT:R-CFA-1562640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LNK binds to p-KIT and inhibit downstream signaling (Canis familiaris)
REACT:R-BTA-420598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:Nectin-4 trans heterodimer formation (Bos taurus)
REACT:R-BTA-4085029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU2 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)
RHEA:17846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH
REACT:R-GGA-5626228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The distal appendage proteins recruit TTBK2 (Gallus gallus)
REACT:R-GGA-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Gallus gallus)
REACT:R-BTA-192475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Bos taurus)
RHEA:37325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-methionine => glycyl-L-methionine + H2O
RHEA:45715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnityl-CoA + CoA <=> acetyl-CoA + N,N,N-trimethylglycyl-CoA
REACT:R-XTR-2466085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from R* to release atRAL (Xenopus tropicalis)
REACT:R-HSA-9652277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds trastuzumab (Homo sapiens)
REACT:R-DRE-3662335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates histone H2A, H2B, H3, H4 (Danio rerio)
REACT:R-BTA-4084978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Bos taurus)
EC:3.2.1.142	skos:altLabel	"R-enzyme"
EC:3.2.1.142	skos:altLabel	"amylopectin-1,6-glucosidase"
EC:3.2.1.142	skos:prefLabel	"limit dextrinase"
EC:3.2.1.142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limit dextrinase"
REACT:R-SSC-190256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to FGF (Sus scrofa)
GO:0050143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isonocardicin A = nocardicin A
GO:0050143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocardicin-A epimerase activity
GO:0050143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isonocardicin A epimerase activity
GO:0050143	skos:prefLabel	"nocardicin-A epimerase"
GO:0050143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nocardicin-A epimerase"
GO:0050143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isonocardicin C = nocardicin C
REACT:R-HSA-9736966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds SERPINE1 gene promoter (Homo sapiens)
REACT:R-DDI-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)
RHEA:36343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 = 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)
RHEA:17975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine => diphosphate + IMP
GO:0005384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	manganese ion transmembrane transporter activity
REACT:R-DME-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Drosophila melanogaster)
EC:3.4.11.5	skos:altLabel	"Pro-X aminopeptidase"
EC:3.4.11.5	skos:prefLabel	"prolyl aminopeptidase"
EC:3.4.11.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prolyl aminopeptidase"
EC:3.4.11.5	skos:altLabel	"proline aminopeptidase"
EC:3.4.11.5	skos:altLabel	"proline iminopeptidase"
EC:3.4.11.5	skos:altLabel	"cytosol aminopeptidase V"
REACT:R-HSA-6802834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GTPase mutants don't hydrolyze GTP (Homo sapiens)
REACT:R-CEL-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Caenorhabditis elegans)
REACT:R-HSA-4755411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates IKBKG with SUMO1 (Homo sapiens)
REACT:R-HSA-8852354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)
REACT:R-SSC-3215310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53 and counteracts MDM2 (Sus scrofa)
RHEA:66256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + IC-asc-C7 = diphosphate + IC-asc-C7-AMP
REACT:R-DRE-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Danio rerio)
REACT:R-CFA-390250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Canis familiaris)
RHEA:46859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-BTA-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Bos taurus)
REACT:R-MMU-159001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)
REACT:R-CEL-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Caenorhabditis elegans)
RHEA:61638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + isophthalyl-CoA => ATP + CoA + isophthalate
REACT:R-DME-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Drosophila melanogaster)
RHEA:47471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-tetradecadienoyl-CoA <=> (3E,5Z)-tetradecadienoyl-CoA
RHEA:55572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine = 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-1676204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Rattus norvegicus)
REACT:R-CEL-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Caenorhabditis elegans)
RHEA:57938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-pyridoxate + 2 H(+) + NADH => H2O + isopyridoxal + NAD(+)
RHEA:25559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate <=> diphosphate + stemod-13(17)-ene
REACT:R-GGA-5676597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Gallus gallus)
GO:0018545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)H nitroreductase activity
EC:3.5.1.28	skos:prefLabel	"N-acetylmuramoyl-L-alanine amidase"
EC:3.5.1.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylmuramoyl-L-alanine amidase"
RHEA:42095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:36873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA
RHEA:31429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S,6R)-alpha-bergamotene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-HSA-1236963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Maturation of phagosome into phagolysosome (Homo sapiens)
REACT:R-HSA-164967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown carnitine exporter transports CAR from the cytosol to the extracellular space (Homo sapiens)
REACT:R-GGA-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Gallus gallus)
RHEA:20484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + coelenterazine h <=> adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate
REACT:R-DRE-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Danio rerio)
REACT:R-DRE-8869607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NAR to yield NAMN (Danio rerio)
RHEA:54064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = 10-epi-cubebol + diphosphate
RHEA:54064	skos:prefLabel	"10-epi-cubebol synthase"
RHEA:54064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"10-epi-cubebol synthase"
REACT:R-HSA-205205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Src family kinases with p-KIT (Homo sapiens)
RHEA:23465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RHEA:65665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + 4 Na(+)(out) => citrate(in) + 4 Na(+)(in)
RHEA:37168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + NAD(+) => (2E,6E)-farnesal + H(+) + NADH
GO:0099511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
RHEA:10899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + limonin <=> 2 H(+) + limonoate
REACT:R-PFA-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Plasmodium falciparum)
GO:0004084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain-amino-acid transaminase activity
GO:0004084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain aminotransferase activity
GO:0004084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-branched chain amino acid aminotransferase activity
GO:0004084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain amino acid-glutamate transaminase activity
GO:0004084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain-amino-acid:2-oxoglutarate aminotransferase activity
GO:0004084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transaminase B activity
GO:0004084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain amino acid aminotransferase activity
GO:0004084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate-branched-chain amino acid transaminase activity
GO:0004084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Homo sapiens)
REACT:R-HSA-351201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal) (Homo sapiens)
REACT:R-MMU-6799203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Mus musculus)
REACT:R-HSA-162590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Import of PIC to the Host Nucleus (Homo sapiens)
REACT:R-CEL-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Caenorhabditis elegans)
RHEA:55543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] <=> 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate
REACT:R-HSA-1980109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)
REACT:R-HSA-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Homo sapiens)
REACT:R-HSA-1989770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PLIN2 (Homo sapiens)
REACT:R-DRE-5638009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Danio rerio)
REACT:R-RNO-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Rattus norvegicus)
RHEA:24924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine => 2-oxobutanoate + NH4(+)
RHEA:24221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] => (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8986994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Homo sapiens)
REACT:R-HSA-400037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi,Go Heterotrimeric G-protein complex dissociates (Homo sapiens)
RHEA:27523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxypyridine + O2 => H(+) + N-formylmaleamate
RHEA:67397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5578663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH3 variant:MSH2-defective DNA mismatch repair (Homo sapiens)
RHEA:61463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in RNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)
RHEA:39282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dodecanoate(out) + H2O <=> ADP + dodecanoate(in) + H(+) + phosphate
REACT:R-HSA-9013992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds to TRIF:activated TLR3 complex (Homo sapiens)
RHEA:69555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + L-glutamate <=> (S)-serinol phosphate + 2-oxoglutarate
REACT:R-DRE-390597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Danio rerio)
REACT:R-SSC-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Sus scrofa)
RHEA:40493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O
GO:0036432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans undecaprenol kinase activity
GO:0036432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-undecaprenol + ATP = ADP + all-trans-undecaprenyl phosphate + H(+)
REACT:R-GGA-2318623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan binds Hyaluronan and HAPLN1 (Gallus gallus)
RHEA:33910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(methylamino)butanoate + H2O + O2 <=> 4-aminobutanoate + formaldehyde + H2O2
REACT:R-GGA-1227881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and release of IRF3 (Gallus gallus)
RHEA:65112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + aculene D + O2 = aculene C + CO2 + H2O + succinate
RHEA:25419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + A + 2 H2O
REACT:R-DME-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Drosophila melanogaster)
REACT:R-DME-3134800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING dimerization (Drosophila melanogaster)
GO:0102245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lupan-3beta,20-diol synthase"
GO:0102245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O
GO:0102245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lupan-3beta,20-diol synthase activity
GO:0102245	skos:prefLabel	"lupan-3beta,20-diol synthase"
RHEA:48172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 + H2O = N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate
REACT:R-BTA-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Bos taurus)
REACT:R-DRE-205231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of KIT upon SCF binding (Danio rerio)
RHEA:24251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-alanine <=> glycine + pyruvate
RHEA:48500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoylglycerol = glycerol + H(+) + octanoate
REACT:R-BTA-3785711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Telomere shortening during replicative exhaustion (Bos taurus)
REACT:R-MMU-1358797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated RNF41 binds P-USP8 (Mus musculus)
GO:0003711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription elongation regulator activity
GO:0003711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcriptional elongation regulator activity
GO:0003711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription elongation factor activity
REACT:R-MMU-6805059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2:FACT phosphorylates TP53 (Mus musculus)
REACT:R-HSA-8954224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A binds CSN2 gene promoter (Homo sapiens)
RHEA:61775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside E + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP
REACT:R-MMU-1234159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome proteolyzes ub-HIF-alpha (Mus musculus)
RHEA:29810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-leucine(out) <=> ADP + H(+) + L-leucine(in) + phosphate
RHEA:64626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl acetate + CoA => (2E)-geraniol + acetyl-CoA
REACT:R-CFA-432121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL binds to LRP8 (Canis familiaris)
REACT:R-BTA-199219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Bos taurus)
RHEA:62515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + melatonin + O2 <=> 2-hydroxymelatonin + CO2 + succinate
RHEA:15460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydrobenzene-1,2-diol + NAD(+) <=> catechol + H(+) + NADH
REACT:R-BTA-6801687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Bos taurus)
REACT:R-HSA-6802932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of BRAF/RAF fusion complex (Homo sapiens)
REACT:R-SPO-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Schizosaccharomyces pombe)
EC:1.17.99.-	skos:prefLabel	"With other acceptors"
EC:1.17.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
REACT:R-DDI-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Dictyostelium discoideum)
REACT:R-HSA-947647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHSR is a receptor for ghrelin (Homo sapiens)
REACT:R-GGA-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
REACT:R-BTA-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Bos taurus)
RHEA:37740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA
REACT:R-HSA-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
REACT:R-BTA-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Bos taurus)
REACT:R-XTR-8855915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Xenopus tropicalis)
RHEA:47963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(tele)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate
GO:0051978	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysophospholipid transporter activity
GO:0051978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophospholipid:sodium symporter activity
RHEA:46377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:31012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => camelliol C
GO:0052767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity
GO:0052767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,6-mannosyl-oligosaccharide alpha-D-mannohydrolase activity
GO:0052767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-oligosaccharide 1,6-alpha-mannosidase activity
GO:0052767	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1,6-alpha-mannosidase activity
GO:0052767	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-1,6-mannosidase activity
REACT:R-DDI-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Dictyostelium discoideum)
REACT:R-SSC-203070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of profilin with monomeric actin (Sus scrofa)
REACT:R-MMU-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Mus musculus)
RHEA:39280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dodecanoate(out) + H2O => ADP + dodecanoate(in) + H(+) + phosphate
GO:0045548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine ammonia-lyase activity
GO:0045548	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PAL activity
GO:0045548	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine ammonium-lyase activity
GO:0045548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine = (E)-cinnamate + NH4(+)
GO:0045548	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine deaminase activity
GO:0045548	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine ammonia-lyase activity
GO:0045548	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phe ammonia-lyase activity
RHEA:40926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-BTA-5666197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds LIN7B (Bos taurus)
REACT:R-RNO-9027532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DHA to 13-HDHA (Rattus norvegicus)
REACT:R-MMU-873926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNGR (Mus musculus)
GO:0038103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activin receptor antagonist activity involved in negative regulation of nodal signaling pathway
GO:0038103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activin receptor antagonist activity involved in negative regulation of nodal signalling pathway
GO:0038103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nodal antagonist activity
REACT:R-DRE-9026003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Danio rerio)
REACT:R-XTR-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Xenopus tropicalis)
REACT:R-MMU-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Mus musculus)
GO:0052887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,9,9'-tricis-neurosporene:quinone oxidoreductase activity
GO:0052887	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ZDS activity
GO:0052887	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	9,9'-di-cis-zeta-carotene desaturase activity
GO:0052887	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	zeta-carotene desaturase activity
RHEA:51852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
GO:0036169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHDB is decarboxylated to DMPhOH by MHDB decarboxylase (Homo sapiens)
GO:0036169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity
RHEA:42719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate <=> (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate
RHEA:55591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide
REACT:R-PFA-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)
REACT:R-XTR-352108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Xenopus tropicalis)
GO:0016630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protochlorophyllide reductase activity
GO:0016630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-protochlorophyllide oxidoreductase activity
GO:0016630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protochlorophyllide photooxidoreductase activity
GO:0016630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-protochlorophyllide reductase activity
GO:0016630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protochlorophyllide oxidoreductase activity
GO:0016630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorophyllide-a:NADP+ 7,8-oxidoreductase activity
GO:0016630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2-protochlorophyllide oxidoreductase activity
RHEA:42896	skos:altLabel	"N(5)-glutamine MTase"
RHEA:42896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine
RHEA:42896	skos:prefLabel	"peptide chain release factor N(5)-glutamine methyltransferase"
RHEA:42896	skos:altLabel	"N(5)-glutamine S-adenosyl-L-methionine dependent methyltransferase"
RHEA:42896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptide chain release factor N(5)-glutamine methyltransferase"
REACT:R-HSA-8983424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)
REACT:R-CFA-6806674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Canis familiaris)
REACT:R-DRE-8937177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD binds ARNT (Danio rerio)
RHEA:49877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)
RHEA:15355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin + H2O + L-dehydroascorbate => all-trans-violaxanthin + L-ascorbate
RHEA:11541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine + NAD(+) => an N-acyl-D-mannosaminolactone + H(+) + NADH
REACT:R-CEL-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Caenorhabditis elegans)
REACT:R-BTA-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Bos taurus)
RHEA:25407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ethyl-2-hydroxy-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate
RHEA:62509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
RHEA:42305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
REACT:R-CFA-8878143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SMAD3 and SMAD4 (Canis familiaris)
REACT:R-DME-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-DRE-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Danio rerio)
RHEA:71666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+)(out) + succinate <=> a menaquinol + fumarate + 2 H(+)(in)
RHEA:16631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + glyoxylate => (S)-malyl-CoA
REACT:R-DRE-392263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR2 (Danio rerio)
RHEA:55847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP
REACT:R-HSA-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Homo sapiens)
REACT:R-CFA-1535903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Canis familiaris)
REACT:R-XTR-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Xenopus tropicalis)
RHEA:36668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine
REACT:R-HSA-76500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBXAS1 isomerises PGH2 to TXA2 (Homo sapiens)
REACT:R-GGA-6804253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates JMY (Gallus gallus)
RHEA:39785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-5654607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PPTN11 (Bos taurus)
REACT:R-MMU-5683735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 is recruited to DNA DSBs (Mus musculus)
RHEA:52522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase]
GO:0102373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uvaol dehydrogenase activity
RHEA:68635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-9714363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC translocates to the endoplasmic reticulum membrane (Rattus norvegicus)
REACT:R-MMU-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)
REACT:R-DME-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)
RHEA:61248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tyrosine + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)
RHEA:17208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate
RHEA:46154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,9'-di-cis-phytofluene + a plastoquinol => 15-cis-phytoene + a plastoquinone
REACT:R-SSC-77338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Sus scrofa)
REACT:R-DRE-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Danio rerio)
REACT:R-BTA-5251955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)
RHEA:54214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin G2)-sn-glycero-3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2
REACT:R-HSA-201486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand pleiotrophin (PTN) (Homo sapiens)
REACT:R-XTR-9707505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to CLEC1B dimer (Xenopus tropicalis)
RHEA:26169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-fumarylpyruvate + H2O => fumarate + H(+) + pyruvate
RHEA:20233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7beta-hydroxysteroid dehydrogenase (NADP(+))"
RHEA:20233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH
RHEA:20233	skos:prefLabel	"7beta-hydroxysteroid dehydrogenase (NADP(+))"
RHEA:20233	skos:altLabel	"NADP-dependent 7beta-hydroxysteroid dehydrogenase"
REACT:R-CFA-8952996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 forms homodimers (Canis familiaris)
REACT:R-XTR-5687640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Xenopus tropicalis)
RHEA:49583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate <=> cyclic pyranopterin phosphate + diphosphate
RHEA:51651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2
REACT:R-SSC-5696491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNTF binds CNTFR complex (Sus scrofa)
RHEA:14567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]
RHEA:66267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + nonanoate <=> diphosphate + nonanoyl-AMP
RHEA:52042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + S-sulfanyl-L-cysteine => L-cystine
REACT:R-DRE-9619376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK1 binds calmodulin (Danio rerio)
RHEA:62327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2
REACT:R-SSC-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Sus scrofa)
REACT:R-XTR-203613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylation of eNOS (Xenopus tropicalis)
REACT:R-MMU-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Mus musculus)
GO:0097177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial ribosome binding
REACT:R-HSA-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Homo sapiens)
REACT:R-CEL-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Caenorhabditis elegans)
REACT:R-XTR-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Xenopus tropicalis)
REACT:R-GGA-177926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of PAG by SHP2 (Gallus gallus)
REACT:R-DME-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Drosophila melanogaster)
RHEA:51086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-9638076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from small HA fragments (Xenopus tropicalis)
RHEA:49158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ins(1,4,5)P3 5-phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-myo-inositol(1,4,5)-trisphosphate 5-phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol polyphosphate-5-phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type I inositol-polyphosphate phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol 1,4,5-trisphosphate phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol triphosphate 5-phosphomonoesterase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol trisphosphate phosphomonoesterase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-myo-inositol 1,4,5-trisphosphate-monoesterase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Homo sapiens)
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	InsP(3) 5-phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II inositol polyphosphate 5-phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5PTase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol phosphate 5-phosphomonoesterase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	InsP3 5-phosphatase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity
GO:0052658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine triphosphatase activity
REACT:R-HSA-901036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN1B1 hydrolyses a second 1,2-linked mannose (a branch) (Homo sapiens)
REACT:R-MMU-2127257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Mus musculus)
REACT:R-MMU-193669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to p75NTR:NRIF (Mus musculus)
RHEA:33486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + ergosterol <=> CoA + ergosteryl ester
RHEA:27622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate
RHEA:27622	skos:prefLabel	"tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]"
RHEA:27622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]"
RHEA:11557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH
REACT:R-HSA-2197562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 stimulates HES1 transcription (Homo sapiens)
RHEA:36084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycerol + H(+) + phosphocholine
GO:0008226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyramine receptor activity
REACT:R-HSA-1678998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosomal TLRs pass through the Golgi (Homo sapiens)
REACT:R-GGA-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Gallus gallus)
REACT:R-MMU-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Mus musculus)
REACT:R-MMU-9688459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds HSP90:CDC37 (Mus musculus)
RHEA:25980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-3640862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase binds AXIN (Bos taurus)
REACT:R-GGA-433826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3. (Gallus gallus)
REACT:R-DDI-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Dictyostelium discoideum)
RHEA:51931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) <=> (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH
RHEA:19575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n+1) + ADP => [phosphate](n) + ATP
RHEA:65522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:61968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CEL-159425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
GO:0047399	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity
GO:0047399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity
GO:0047399	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glucose-1-phosphate phosphodiesterase activity
REACT:R-HSA-83791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Homo sapiens)
REACT:R-GGA-191062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of Klotho-bound FGFR1c (Gallus gallus)
RHEA:31184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + decanoyl-CoA => 3-oxododecanoyl-CoA + CoA
RHEA:12804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[tau protein] <=> ADP + H(+) + O-phospho-L-seryl-[tau protein]
RHEA:49459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + H2O <=> (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate
REACT:R-HSA-6814374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kazrin binds periplakin (Homo sapiens)
REACT:R-BTA-6799695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX5,6 reduce H2O2 to H2O (Bos taurus)
GO:0018654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-phenylacetate hydroxylase activity
RHEA:28579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(2+)(in) => Co(2+)(out)
REACT:R-RNO-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Rattus norvegicus)
REACT:R-XTR-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Xenopus tropicalis)
RHEA:28030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dGDP + H2O = [thioredoxin]-dithiol + GDP
RHEA:62073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose 6-phosphate + NADP(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH
RHEA:20121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)
RHEA:20121	skos:prefLabel	"glutamine--tRNA ligase"
RHEA:20121	skos:altLabel	"glutamine translase"
RHEA:20121	skos:altLabel	"glutaminyl-tRNA synthetase"
RHEA:20121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamine--tRNA ligase"
GO:0030373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high molecular weight B cell growth factor receptor activity
GO:0030373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high molecular weight B-cell growth factor receptor activity
GO:0030373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMW-BCGF receptor
GO:0030373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high molecular weight B-lymphocyte growth factor receptor activity
GO:0030373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high molecular weight B lymphocyte growth factor receptor activity
RHEA:44881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[receptor-protein] => ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]
REACT:R-GGA-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Gallus gallus)
RHEA:34006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 <=> 7-dehydrodesmosterol + 2 H2O + NADP(+)
RHEA:65555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + lactose
REACT:R-MMU-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Mus musculus)
REACT:R-XTR-997309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of STAT1 by SHP2 (Xenopus tropicalis)
REACT:R-HSA-5602147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP2R1 does not 25-hydroxylate vitamin D (Homo sapiens)
REACT:R-MMU-199032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADCAM1-1 binds Integrin alpha4beta7 (Mus musculus)
RHEA:24066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + porphobilinogen => 2 5-aminolevulinate
RHEA:31817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-DME-3000122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD320 binds extracellular TCN2:RCbl (Drosophila melanogaster)
RHEA:25839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H(+)
RHEA:58678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide => NADPH + O2 + rifamycin SV
RHEA:45617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine
RHEA:30600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 3 A => 3 AH2 + all-trans-neurosporene
GO:0102472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eriodictyol 2-hydroxylase activity
GO:0045703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ketoreductase activity
REACT:R-HSA-2453818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective STRA6 does not transport atROL (Homo sapiens)
REACT:R-SSC-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Sus scrofa)
REACT:R-BTA-1358797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated RNF41 binds P-USP8 (Bos taurus)
RHEA:49757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O2 + protoviolaceinate => CO2 + H2O + proviolacein
GO:0019983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-9 binding
GO:0019983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-9 binding
REACT:R-XTR-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Xenopus tropicalis)
REACT:R-CFA-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Canis familiaris)
RHEA:69870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in RNA + S-adenosyl-L-methionine <=> a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine
RHEA:51530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + guaiacol => H(+) + vanillate
REACT:R-HSA-8877493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)
REACT:R-SSC-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Sus scrofa)
RHEA:62308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-malbrancheamide B + FADH2
RHEA:31838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose
REACT:R-CEL-5661125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2sR4-HIST1H4 (Caenorhabditis elegans)
RHEA:22293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + 3 H(+) + 3 malonyl-CoA => biphenyl-3,5-diol + 4 CO2 + 4 CoA
RHEA:43371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-RNO-2574845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA binds centrosome-associated AURKA (Rattus norvegicus)
REACT:R-SSC-1295634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is serine phosphorylated in response to MAPK activation (Sus scrofa)
REACT:R-MMU-975142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Mus musculus)
RHEA:33607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
REACT:R-MTU-936729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate is activated to APS (Mycobacterium tuberculosis)
RHEA:48025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tripropanoylglycerol + H2O => dipropanoylglycerol + H(+) + propanoate
RHEA:53122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+)
RHEA:28506	skos:altLabel	"Kdo kinase"
RHEA:28506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)
RHEA:28506	skos:prefLabel	"3-deoxy-D-manno-octulosonic acid kinase"
RHEA:28506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-D-manno-octulosonic acid kinase"
RHEA:19378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + reduced riboflavin => 2 H(+) + NADPH + riboflavin
REACT:R-RNO-4570489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO2 (Rattus norvegicus)
REACT:R-DDI-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)
REACT:R-DRE-977602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to MCP, CR1:C4b, C3b (Danio rerio)
REACT:R-DRE-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Danio rerio)
REACT:R-GGA-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Gallus gallus)
EC:1.5.1.54	skos:altLabel	"N(5),10-methylenetetrahydrofolate reductase"
EC:1.5.1.54	skos:altLabel	"5,10-methylenetetrahydrofolate reductase"
EC:1.5.1.54	skos:prefLabel	"methylenetetrahydrofolate reductase (NADH)"
EC:1.5.1.54	skos:altLabel	"5,10-methylenetetrahydrofolate reductase (FADH2)"
EC:1.5.1.54	skos:altLabel	"5,10-CH2-H4folate reductase"
EC:1.5.1.54	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylenetetrahydrofolate reductase (NADH)"
REACT:R-XTR-6786155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLN binds ICL-DNA (Xenopus tropicalis)
REACT:R-HSA-5682802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI3 binds ADAM22,23,synatxin1 (Homo sapiens)
REACT:R-RNO-193766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
REACT:R-RNO-9701000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1:BARD1 heterodimer autoubiquitinates (Rattus norvegicus)
RHEA:24813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate
EC:1.1.1.71	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol dehydrogenase [NAD(P)(+)]"
EC:1.1.1.71	skos:altLabel	"retinal reductase"
EC:1.1.1.71	skos:prefLabel	"alcohol dehydrogenase [NAD(P)(+)]"
REACT:R-GGA-6805943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A1 binds TLR4:LY96 (Gallus gallus)
REACT:R-RNO-8849638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the SPINK5:KLK5 complex at low pH (Rattus norvegicus)
RHEA:51469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + a quinone => a quinol + pyruvate
RHEA:22061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:61247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan + O2 <=> H2O2 + indole-3-pyruvate + NH4(+)
REACT:R-SSC-1604741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP14 (MT1-MMP) (Sus scrofa)
RHEA:51547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose <=> D-xylulose
REACT:R-MMU-936897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)
RHEA:23738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => 5-hydroxyisourate + H2O
GO:0009022	skos:altLabel	"RNase PH"
GO:0009022	skos:altLabel	"ribonuclease PH"
GO:0009022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase PH activity
GO:0009022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA:phosphate nucleotidyltransferase activity
GO:0009022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate-dependent exonuclease activity
GO:0009022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA nucleotidyltransferase"
GO:0009022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease PH activity
GO:0009022	skos:altLabel	"phosphate-dependent exonuclease"
GO:0009022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)
GO:0009022	skos:prefLabel	"tRNA nucleotidyltransferase"
REACT:R-BTA-879221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSTPIP1 binds Pyrin (Bos taurus)
RHEA:70620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-5686430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81 binds EME1, EME2 (Canis familiaris)
REACT:R-CFA-74207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Canis familiaris)
REACT:R-BTA-140872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)
REACT:R-HSA-5634802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Homo sapiens)
REACT:R-BTA-4724279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Bos taurus)
REACT:R-XTR-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Xenopus tropicalis)
RHEA:34776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) => a 3-oxosteroid + CO2 + NADH
RHEA:64611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UTP <=> diphosphate + uridylyl-L-threonyl-[protein]
REACT:R-HSA-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Homo sapiens)
RHEA:41781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide
REACT:R-XTR-173626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1r (Xenopus tropicalis)
REACT:R-BTA-5607723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)
REACT:R-DRE-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Danio rerio)
REACT:R-BTA-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Bos taurus)
RHEA:56343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9648017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 binds to microtubules (Homo sapiens)
REACT:R-CFA-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Canis familiaris)
RHEA:49539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate <=> (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O
REACT:R-RNO-8987230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Rattus norvegicus)
REACT:R-CFA-373074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR9  binds CCL25 ligand (Canis familiaris)
REACT:R-PFA-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Plasmodium falciparum)
RHEA:45713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnityl-CoA + CoA => acetyl-CoA + N,N,N-trimethylglycyl-CoA
REACT:R-MMU-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Mus musculus)
REACT:R-HSA-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Homo sapiens)
REACT:R-HSA-379848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)
REACT:R-SSC-6804242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the complex of JMY, EP300 and TTC5 (Sus scrofa)
RHEA:36524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
REACT:R-GGA-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Gallus gallus)
REACT:R-SSC-5323526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRAT proteins bind GSK3beta (Sus scrofa)
RHEA:54253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
RHEA:36130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A34 + S-adenosyl-L-methionine <=> O-methyl gibberellin A34 + S-adenosyl-L-homocysteine
REACT:R-RNO-8855237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Rattus norvegicus)
REACT:R-XTR-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Xenopus tropicalis)
GO:0008389	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2A5
GO:0008389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)
GO:0008389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A6 (Homo sapiens)
GO:0008389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coumarin 7-hydroxylase activity
RHEA:22639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + H2O <=> dCMP + diphosphate + H(+)
REACT:R-MMU-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Mus musculus)
REACT:R-BTA-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Bos taurus)
REACT:R-HSA-5654669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)
RHEA:43031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteate <=> 2-aminoprop-2-enoate + H(+) + sulfite
REACT:R-HSA-8874078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Homo sapiens)
RHEA:51838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out)
RHEA:65190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	berkeleydione + CO2 + H2O + succinate => 2-oxoglutarate + berkeleyone B + O2
REACT:R-HSA-6813626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEAP2 binds bacteria (Homo sapiens)
REACT:R-SSC-450422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP recruits RNA degradation activities (Sus scrofa)
RHEA:61723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-guloside + NAD(+) <=> a 3-dehydro-D-guloside + H(+) + NADH
GO:1990471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	piRNA uni-strand cluster binding
RHEA:46213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine => 4-amino-5-aminomethyl-2-methylpyrimidine + formate
REACT:R-HSA-5658424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Homo sapiens)
EC:3.4.3.-	skos:prefLabel	"Dipeptide hydrolases"
EC:3.4.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Dipeptide hydrolases"
RHEA:64469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) => 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH
REACT:R-MMU-6795460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK1 phosphorylates MDM2 (Mus musculus)
RHEA:28152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(1)-acetylspermidine => acetyl-CoA + spermidine
RHEA:51808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
REACT:R-GGA-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Gallus gallus)
REACT:R-RNO-5229111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 transports APP from trans-Golgi network to endosome lumen (Rattus norvegicus)
GO:0015361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity sodium:dicarboxylate symporter activity
GO:0015361	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	low affinity sodium:dicarboxylate cotransporter activity
GO:0015361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC1 co-transports dicarboxylic acids and a sodium ion (Homo sapiens)
GO:0015361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity sodium:dicarboxylate symporter activity
RHEA:52097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-octadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + octadecanoate
GO:0016154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Py-NPase activity
GO:0016154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity
GO:0016154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine-nucleoside phosphorylase activity
REACT:R-XTR-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Xenopus tropicalis)
REACT:R-DRE-8854302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D7 binds the TSC1-TSC2 complex (Danio rerio)
REACT:R-MMU-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Mus musculus)
RHEA:45178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-9014449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the plasma membrane (Homo sapiens)
GO:0034875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine oxidase activity
REACT:R-HSA-9759364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2-dependent TXNRD1 gene expression (Homo sapiens)
REACT:R-DRE-190263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3b binds to FGF (Danio rerio)
REACT:R-RNO-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Rattus norvegicus)
REACT:R-RNO-9021079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs:CAVs translocate to plasma membrane (Rattus norvegicus)
REACT:R-HSA-2022368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-42) (Homo sapiens)
RHEA:56359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)
REACT:R-DME-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
RHEA:36306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)
REACT:R-DRE-3928617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB2 binds KALRN (Danio rerio)
RHEA:32816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hg(2+)(in) => Hg(2+)(out)
RHEA:34949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + NH4(+) => (Z)-3-aminoacrylate + H(+) + H2O
REACT:R-HSA-5205649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 links damaged mitochondria to LC3 (Homo sapiens)
REACT:R-SPO-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Schizosaccharomyces pombe)
REACT:R-GGA-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Gallus gallus)
REACT:R-XTR-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Xenopus tropicalis)
RHEA:53225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1295604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-RAF dissociates from S111/S120 p-SPRY2 (Rattus norvegicus)
REACT:R-BTA-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Bos taurus)
GO:0033432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine tRNA
GO:0033432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGG codon-amino acid adaptor activity
RHEA:70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + alpha-D-glucosaminyl-[heparan sulfate](n) => H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)
REACT:R-GGA-5685994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Long-range resection of DNA DSBs by EXO1 or DNA2 (Gallus gallus)
REACT:R-DRE-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Danio rerio)
RHEA:46376	skos:prefLabel	"acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)"
RHEA:46376	skos:altLabel	"oleate desaturase"
RHEA:46376	skos:altLabel	"acyl-lipid omega(6)-desaturase (ferredoxin)"
RHEA:46376	skos:altLabel	"phosphatidylcholine desaturase"
RHEA:46376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:46376	skos:altLabel	"linoleate synthase"
RHEA:46376	skos:altLabel	"oleoyl-CoA desaturase"
RHEA:46376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)"
REACT:R-HSA-9712079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK mutants bind STAT3 (Homo sapiens)
RHEA:39416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)
REACT:R-DRE-8876868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE1 cleaves EDN1(53-90) (Danio rerio)
REACT:R-RNO-8849646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK5(490-624) binds KLK5 (Rattus norvegicus)
RHEA:28077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfopropanediol + H2O + 2 NAD(+) <=> (2R)-3-sulfolactate + 3 H(+) + 2 NADH
REACT:R-PFA-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Plasmodium falciparum)
RHEA:41741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine
REACT:R-DDI-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Dictyostelium discoideum)
RHEA:22016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutaredoxin]-dithiol + arsenate + glutathione + H(+) = arsenite + glutathionyl-S-S-[glutaredoxin] + H2O
RHEA:22016	skos:altLabel	"arsenate reductase (glutaredoxin)"
RHEA:22016	skos:prefLabel	"arsenate reductase (glutathione/glutaredoxin)"
RHEA:22016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arsenate reductase (glutathione/glutaredoxin)"
REACT:R-DRE-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Danio rerio)
REACT:R-RNO-8983335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Rattus norvegicus)
REACT:R-DDI-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)
REACT:R-BTA-4086036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate NRIP1 with SUMO1 (Bos taurus)
RHEA:46231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[peptidyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]
REACT:R-DRE-1362465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GHR (Danio rerio)
RHEA:71867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate(out) = glycodeoxycholate(in)
RHEA:16942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylindoxyl + O2 => H2O + N-acetylisatin
RHEA:24414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-formylbenzenesulfonate + H(+) + NADH => 4-(hydroxymethyl)benzenesulfonate + NAD(+)
RHEA:38381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+)
REACT:R-RNO-9024997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Rattus norvegicus)
RHEA:59567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone <=> H(+) + N,N',N'',N'''-tetraacetylchitotetraonate
REACT:R-HSA-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Homo sapiens)
RHEA:38522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)
RHEA:59622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + L-lysine => H2O + N(2)-(4-aminobutanoyl)-L-lysine
RHEA:35797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + kanamycin A + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine
GO:0001793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgM receptor activity
REACT:R-DRE-201790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 is dephosphorylated on Thr75 by PP2A (Danio rerio)
RHEA:69928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(out) + Na(+)(out) => adenosine(in) + Na(+)(in)
REACT:R-CFA-379415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Canis familiaris)
REACT:R-SSC-1234167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of HIF:CBP:p300 complex at promoters (Sus scrofa)
REACT:R-MMU-1358789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Self-ubiquitination of RNF41 (Mus musculus)
REACT:R-CFA-9654533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B recycles to the plasma membrane (Canis familiaris)
REACT:R-SCE-9635739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 dephosphorylates p-T,Y-MAPKs (Saccharomyces cerevisiae)
REACT:R-BTA-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Bos taurus)
REACT:R-MMU-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
REACT:R-MMU-2066780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)
REACT:R-CEL-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Caenorhabditis elegans)
RHEA:71332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) => chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)
REACT:R-SSC-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Sus scrofa)
RHEA:17317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorophyll synthase"
RHEA:17317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H(+) + phytyl diphosphate = chlorophyll a + diphosphate
RHEA:17317	skos:prefLabel	"chlorophyll synthase"
RHEA:33110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-muurolene
REACT:R-RNO-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Rattus norvegicus)
REACT:R-SSC-2028644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Sus scrofa)
REACT:R-XTR-2309773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS2 (Xenopus tropicalis)
RHEA:71459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9)
RHEA:41812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+)
RHEA:46571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Homo sapiens)
REACT:R-RNO-159567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform ST to ST-CoA (Rattus norvegicus)
RHEA:65987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hnu + previtamin D3 <=> lumisterol 3
REACT:R-HSA-73920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Homo sapiens)
REACT:R-XTR-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Xenopus tropicalis)
REACT:R-XTR-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Xenopus tropicalis)
RHEA:53228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:37126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine
RHEA:16351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chlorite + H2O => AH2 + chlorate
RHEA:44372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cr(6+) + 2 NADH + O2 = Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide
RHEA:34058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	festuclavine + NAD(+) <=> 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH
RHEA:47203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-7alpha-dihydroxycholesterol + NAD(+) <=> (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH
RHEA:51485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:58944	skos:altLabel	"spectinabilin polyketide synthase complex"
RHEA:58944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH = 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)
RHEA:58944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spectinabilin polyketide synthase system"
RHEA:58944	skos:prefLabel	"spectinabilin polyketide synthase system"
RHEA:53239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:47021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite
RHEA:62707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyldehydrophenylalanine + H2O <=> 2,3-didehydrophenylalanine + glycine
REACT:R-DME-5690991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Drosophila melanogaster)
RHEA:33602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine
RHEA:34900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + S-adenosyl-L-methionine => malonyl-CoA methyl ester + S-adenosyl-L-homocysteine
GO:0003677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA binding
GO:0003677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	structure specific DNA binding
GO:0003677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	structure-specific DNA binding
GO:0003677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	microtubule/chromatin interaction
GO:0003677	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plasmid binding
REACT:R-HSA-5626356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)
REACT:R-DRE-9035227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN2 binds CysS248-MPST (Danio rerio)
REACT:R-XTR-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Xenopus tropicalis)
RHEA:71016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methylputrescine + O2 => 4-methylaminobutanal + H2O2 + NH4(+)
RHEA:65393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH => (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)
REACT:R-RNO-9796691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPATA2 links CYLD to LUBAC (Rattus norvegicus)
REACT:R-HSA-4086083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of ING2 with SUMO1 (Homo sapiens)
REACT:R-SCE-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Saccharomyces cerevisiae)
REACT:R-BTA-5693574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Bos taurus)
RHEA:29766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate
REACT:R-DDI-110375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Dictyostelium discoideum)
RHEA:11538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + H(+) + 2 H2O2 => choline + H2O + 2 O2
REACT:R-GGA-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Gallus gallus)
RHEA:16197	skos:altLabel	"beta-hydroxybutyryl-CoA dehydrogenase"
RHEA:16197	skos:prefLabel	"3-hydroxybutyryl-CoA dehydrogenase"
RHEA:16197	skos:altLabel	"BHBD"
RHEA:16197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH
RHEA:16197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybutyryl-CoA dehydrogenase"
RHEA:41257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
REACT:R-CFA-5654425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds SHC1 (Canis familiaris)
REACT:R-DRE-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Danio rerio)
REACT:R-XTR-139920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tBID to mitochondria (Xenopus tropicalis)
REACT:R-MMU-446684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Mus musculus)
REACT:R-DRE-69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk1 (Danio rerio)
REACT:R-DDI-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Dictyostelium discoideum)
REACT:R-MMU-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Mus musculus)
REACT:R-CFA-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)
RHEA:25016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-tryptophan <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O
RHEA:43282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O
REACT:R-CEL-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Caenorhabditis elegans)
REACT:R-RNO-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Rattus norvegicus)
REACT:R-HSA-3858491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs bind the FZD receptor to initiate PCP pathway (Homo sapiens)
GO:0031320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexitol dehydrogenase activity
RHEA:42021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-dehydrocorticosterone + NAD(+) => H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone
REACT:R-HSA-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Homo sapiens)
REACT:R-GGA-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Gallus gallus)
REACT:R-RNO-2428922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Rattus norvegicus)
RHEA:42425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylmaleate + H2O => (2R,3S)-3-methylmalate
RHEA:58562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + NADPH => 15alpha-stemmadenine intermediate II + NADP(+)
RHEA:23041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + acetyl-CoA + H2O => (R)-2-ethylmalate + CoA + H(+)
REACT:R-DRE-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Danio rerio)
RHEA:30432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => taraxerol
RHEA:26376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + prostamide F2alpha <=> [thioredoxin]-dithiol + prostamide H2
REACT:R-DRE-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Danio rerio)
REACT:R-MMU-8851877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Mus musculus)
RHEA:15280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysyl-[alpha-tubulin] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]
REACT:R-HSA-8865711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner (Homo sapiens)
REACT:R-MMU-1369028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid efflux (Mus musculus)
REACT:R-SSC-77594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Sus scrofa)
RHEA:63209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + glyoxal => 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O
REACT:R-CEL-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Caenorhabditis elegans)
REACT:R-HSA-912757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)
RHEA:19310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O => (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate
REACT:R-SSC-71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Sus scrofa)
REACT:R-MMU-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)
REACT:R-MMU-9750226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 binds IKBKB and CHUK (Mus musculus)
RHEA:49901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine-1,6-dicarboxylate + O2 => H2O2 + phenazine-1,6-dicarboxylate
REACT:R-CEL-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
REACT:R-BTA-3858495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits GTP-bound RHOA (Bos taurus)
GO:0102996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta,beta digalactosyldiacylglycerol galactosyltransferase activity
RHEA:35532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-phenylalanyl-L-leucyl) + 2 O2 => albonoursin + 2 H2O2
REACT:R-RNO-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Rattus norvegicus)
RHEA:45714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnityl-CoA + CoA
REACT:R-HSA-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Homo sapiens)
REACT:R-XTR-9679028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 binds JAK3 inhibitors (Xenopus tropicalis)
REACT:R-HSA-5676589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANKL,sRANKL trimer binds RANK (Homo sapiens)
GO:0102114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caprate dehydroxylase activity
RHEA:46336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-4,17-dien-22-oyl-CoA + H2O = 17-hydroxy-3-oxochol-4-en-22-oyl-CoA
RHEA:68514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-acoradiene + diphosphate => (2Z,6Z)-farnesyl diphosphate
RHEA:47457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) => 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH
REACT:R-RNO-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Rattus norvegicus)
REACT:R-MMU-8853429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLDA1 binds AURKA (Mus musculus)
RHEA:51184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphoserine + H2O = H(+) + octadecanoate + sn-glycero-3-phospho-L-serine
REACT:R-RNO-265422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaEbeta7 with Cadherin-1 (Rattus norvegicus)
GO:0047871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity
GO:0047871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-sulfoglucosamine-6-sulfatase activity
GO:0047871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	disulfoglucosamine-6-sulfatase activity
GO:0047871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6,N-disulfoglucosamine 6-O-sulfohydrolase activity
GO:0047871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	disulphoglucosamine-6-sulphatase activity
REACT:R-DDI-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)
GO:0015418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quaternary-ammonium-compound-transporting ATPase activity
GO:0015418	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycine betaine/proline porter activity
GO:0015418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quaternary amine uptake transporter activity
GO:0015418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled quaternary ammonium compound transmembrane transporting activity
GO:0015418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quaternary-ammonium-compound ABC transporter
GO:0015418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type quaternary ammonium compound transporting activity
GO:0015418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quaternary-amine-transporting ATPase activity
GO:0015418	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	quarternary amine transporter activity
GO:0015418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent quaternary-ammonium compound transmembrane transporting activity
REACT:R-CFA-5690023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL binds 4Fe-4S (Canis familiaris)
REACT:R-PFA-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Plasmodium falciparum)
REACT:R-HSA-378975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follitropin is a heterodimer (Homo sapiens)
GO:0051424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticoliberin binding
GO:0051424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRF binding
GO:0051424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin-releasing factor binding
GO:0051424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin-releasing hormone binding
GO:0051424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRH binding
RHEA:47777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-2179274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD3 phosphorylated in the linker region (Danio rerio)
RHEA:69360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + H(+) + H2O2 + L-tyrosyl-[protein] = 3-bromo-L-tyrosyl-[protein] + 2 H2O
REACT:R-RNO-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Rattus norvegicus)
RHEA:52714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate + thymine => dTMP + H2O
RHEA:66482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenin 28-beta-D-glucoside + UDP => gypsogenin + UDP-alpha-D-glucose
REACT:R-DME-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Drosophila melanogaster)
RHEA:51823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + decanoate(out) + H(+)(out) <=> AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)
RHEA:38778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
GO:0050095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine decarboxylase activity
GO:0050095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine decarboxylase activity
GO:0050095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionine = 3-(methylsulfanyl)propanamine + CO2
GO:0050095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionine decarboxylase"
GO:0050095	skos:altLabel	"L-methionine decarboxylase"
GO:0050095	skos:altLabel	"L-methionine carboxy-lyase"
GO:0050095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine carboxy-lyase (3-methylthiopropanamine-forming)
GO:0050095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine carboxy-lyase activity
GO:0050095	skos:prefLabel	"methionine decarboxylase"
REACT:R-BTA-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)
REACT:R-BTA-5635741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Bos taurus)
REACT:R-CEL-446083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD151 interacts with BP180 and the integrin alpha 6 subunit (Caenorhabditis elegans)
RHEA:24979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]
RHEA:25371	skos:altLabel	"2-amino-2-deoxyisochorismate dehydrogenase"
RHEA:25371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2
RHEA:25371	skos:prefLabel	"2-amino-4-deoxychorismate dehydrogenase"
RHEA:25371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-amino-4-deoxychorismate dehydrogenase"
RHEA:25371	skos:altLabel	"ADIC dehydrogenase"
REACT:R-MMU-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Mus musculus)
RHEA:46763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitrotoluene + NADH + O2 <=> 4-methyl-5-nitrocatechol + NAD(+) + nitrite
REACT:R-BTA-83650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FasL:Fas binds FADD (Bos taurus)
REACT:R-RNO-937311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP12A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
REACT:R-SSC-3249378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING recruits TBK1 and STAT6 (Sus scrofa)
RHEA:39784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:20122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln)
RHEA:34649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + squalene
RHEA:21307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Drosophila melanogaster)
REACT:R-MMU-201521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK autophosphorylation downstream of PTN and MDK (Mus musculus)
RHEA:14064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(carboxymethyl)-D-alanine + NAD(+) <=> glycine + H(+) + NADH + pyruvate
GO:0102748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl-chlorophyll a reductase activity
REACT:R-XTR-202237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP3 to PI(3,4)P2 (Xenopus tropicalis)
RHEA:34566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-abequose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH
RHEA:61713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine => 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine
REACT:R-RNO-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Rattus norvegicus)
REACT:R-XTR-8948709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Xenopus tropicalis)
REACT:R-BTA-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Bos taurus)
REACT:R-CFA-9610750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Canis familiaris)
RHEA:71896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide
GO:0019202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid kinase activity
RHEA:53422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + roseoflavin + S-adenosyl-L-homocysteine => 8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine
RHEA:29346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate(in) + succinate(out) <=> L-aspartate(out) + succinate(in)
REACT:R-SCE-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Saccharomyces cerevisiae)
GO:0052730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sarcosine N-methyltransferase activity
GO:0052730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SDMT
GO:0052730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:N,N-sarcosine N-methyltransferase activity
RHEA:27619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate => di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate
RHEA:49533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O => ethylene glycol + H(+) + terephthalate
RHEA:49513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylisomalate
REACT:R-HSA-1368140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PPARGC1A (PGC-1alpha) (Homo sapiens)
RHEA:17176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathionylspermidine + H2O <=> glutathione + spermidine
REACT:R-RNO-8937191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Rattus norvegicus)
REACT:R-HSA-9634934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5R1 gene expression is stimulated by NPAS4 (Homo sapiens)
RHEA:46097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + dihydropinosylvin
REACT:R-MMU-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Mus musculus)
RHEA:38679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sphinganine(in) = ADP + H(+) + phosphate + sphinganine(out)
REACT:R-GGA-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Gallus gallus)
RHEA:44355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide C + H(+) + phosphate
RHEA:57577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]
RHEA:61434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeranial + H(+) + NADPH => (R)-8-oxocitronellyl enol + NADP(+)
RHEA:10389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate
RHEA:46943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] <=> ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate
RHEA:41105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O
GO:0009017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-succinyl-L-glutamate amidohydrolase activity
GO:0009017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SGDS
GO:0009017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinylglutamate desuccinylase activity
GO:0009017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2-succinylglutamate desuccinylase activity
GO:0009017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AstE
REACT:R-CFA-4793925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S303,307-HSF1 binds YWHAE (14-3-3) (Canis familiaris)
REACT:R-HSA-1475414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Homo sapiens)
REACT:R-CFA-5624127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome target cargo to the primary cilium (Canis familiaris)
RHEA:30158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + 2 Fe(3+) <=> FAD + 2 Fe(2+) + 3 H(+)
REACT:R-SSC-5694431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Sus scrofa)
RHEA:66996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpentanoate + ATP + CoA = 2-methylpentanoyl-CoA + AMP + diphosphate
REACT:R-SSC-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Sus scrofa)
REACT:R-PFA-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Plasmodium falciparum)
REACT:R-HSA-9024993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Homo sapiens)
REACT:R-XTR-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)
RHEA:40587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanedioyl-CoA = CoA + H(+) + octanedioate
GO:0102383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviol 19-O glucosyltransferase activity
REACT:R-CFA-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Canis familiaris)
RHEA:55613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O => 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)
RHEA:27762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H2O = CMP + diphosphate + H(+)
REACT:R-MMU-6801808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A,REG3G binds bacterial peptidoglycan (Mus musculus)
RHEA:42842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+) => acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH
RHEA:24153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + ATP => 3'-phosphoadenylyl sulfate + ADP + H(+)
RHEA:10009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + a hydroperoxide => [protein]-disulfide + an alcohol + H2O
RHEA:21190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + NAD(+) => ATP + deamido-NAD(+) + NH4(+)
REACT:R-CFA-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)
REACT:R-CFA-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Canis familiaris)
GO:0018760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiocyanate aminohydrolase activity
GO:0018760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiocyanate hydrolase activity
GO:1990605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GU repeat RNA binding
GO:0022840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leak channel activity
REACT:R-BTA-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Bos taurus)
REACT:R-HSA-9708430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 (CRM1) binds to BACH1:Hemes (Homo sapiens)
RHEA:70329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + H(+) + NADH => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+)
RHEA:32782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Co(2+)(out) + H2O <=> ADP + Co(2+)(in) + H(+) + phosphate
RHEA:50456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H3 = prostaglandin D3
REACT:R-HSA-211929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C19 5-hydroxylates omeprazole (Homo sapiens)
REACT:R-MMU-2730664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Mus musculus)
RHEA:71183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine(out) + L-tryptophan(in) = L-kynurenine(in) + L-tryptophan(out)
REACT:R-CEL-1614460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of procollagen type VI (Caenorhabditis elegans)
RHEA:71665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + fumarate + 2 H(+)(in) => a menaquinone + 2 H(+)(out) + succinate
RHEA:17366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mn(2+)(out) => ADP + H(+) + Mn(2+)(in) + phosphate
RHEA:64882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + phosphate => CDP + H2O
GO:0047839	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dATP(dGTP):depurinated-DNA purine transferase activity
GO:0047839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP(dGTP)-DNA purinetransferase activity
GO:0047839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP(dGTP)--DNA purine transferase activity
REACT:R-RNO-211164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO1A (Rattus norvegicus)
RHEA:43333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine
RHEA:48994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+) => 1,3,7-trimethylurate + H(+) + NADH + O2
REACT:R-DME-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Drosophila melanogaster)
REACT:R-HSA-9714480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the mitochondrial membrane (Homo sapiens)
REACT:R-CFA-2022063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Canis familiaris)
REACT:R-PFA-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-SCE-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)
REACT:R-MMU-9650165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers bind H+ (Mus musculus)
REACT:R-SPO-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Schizosaccharomyces pombe)
REACT:R-HSA-112271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex dissociates (Homo sapiens)
REACT:R-DRE-9610152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Danio rerio)
RHEA:46881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP
RHEA:62662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'R)-atrovenetin => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol
RHEA:19274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate => N-acetylneuraminate + phosphate
RHEA:34667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + S-adenosyl-L-methionine = 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Gallus gallus)
GO:0030796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity
GO:0030796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloartenol 24-C-methyltransferase activity
GO:0030796	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sterol C-methyltransferase activity
RHEA:21462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 benzaldehyde => benzoin
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl-ACP hydrolase activity
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lauryl-acyl-carrier protein hydrolase activity
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dodecyl-[acyl-carrier protein] hydrolase activity
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-ACP hydrolase activity
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lauryl-acyl-carrier-protein hydrolase activity
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lauryl-[acyl-carrier protein] hydrolase activity
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-[acyl-carrier-protein] hydrolase activity
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dodecanoyl-acyl-carrier-protein hydrolase activity
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-[acyl-carrier protein] hydrolase activity
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl-[acyl-carrier-protein] hydrolase activity
GO:0047381	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dodecyl-acyl-carrier protein hydrolase
REACT:R-CFA-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Canis familiaris)
REACT:R-HSA-445448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHIP binds Hedgehog (Homo sapiens)
REACT:R-SSC-8937744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-7Y-RUNX1 (Sus scrofa)
RHEA:59704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellohexaono-1,5-lactone + H2O = D-cellohexaonate + H(+)
REACT:R-MMU-373342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3CR1 binds CX3CL1 (Mus musculus)
REACT:R-BTA-5694431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Bos taurus)
RHEA:30935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nicotinate beta-D-ribonucleotide = beta-D-ribosylnicotinate + phosphate
REACT:R-HSA-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Homo sapiens)
REACT:R-RNO-5671970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CIT binds KIF14 and PRC1 (Rattus norvegicus)
REACT:R-RNO-8955844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBKS phosphorylates ribose to R5P (Rattus norvegicus)
RHEA:39440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O
REACT:R-MMU-8853405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 binds AURKA at centrosomes (Mus musculus)
REACT:R-DRE-450358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Danio rerio)
EC:3.2.2.29	skos:altLabel	"uracil/thymine DNA glycosylase"
EC:3.2.2.29	skos:altLabel	"mismatch-specific thymine-DNA glycosylase"
EC:3.2.2.29	skos:altLabel	"mismatch-specific thymine-DNA N-glycosylase"
EC:3.2.2.29	skos:altLabel	"TDG"
EC:3.2.2.29	skos:prefLabel	"thymine-DNA glycosylase"
EC:3.2.2.29	skos:altLabel	"thymine DNA glycosylase"
EC:3.2.2.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thymine-DNA glycosylase"
REACT:R-CFA-983218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B:RAD51C binds single-stranded DNA (Canis familiaris)
REACT:R-HSA-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Homo sapiens)
REACT:R-MMU-5263614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)
REACT:R-CEL-4724279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Caenorhabditis elegans)
REACT:R-DDI-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Dictyostelium discoideum)
RHEA:38899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)
REACT:R-DRE-8854738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR binds CSFR (Danio rerio)
REACT:R-CEL-9632918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Caenorhabditis elegans)
REACT:R-DRE-429786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Danio rerio)
REACT:R-SSC-9015111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors binds Xa (Sus scrofa)
REACT:R-MMU-352385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Mus musculus)
REACT:R-BTA-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Bos taurus)
REACT:R-MMU-5252072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AZGP1 binds PIP (Mus musculus)
RHEA:58337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-hydroxynonen-1-ol + NADP(+) => a 4-hydroxynonenal + H(+) + NADPH
RHEA:37083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine = [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine
RHEA:32942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-DME-174132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Cyclin B:Cdc2 (Drosophila melanogaster)
RHEA:11770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + anthranilate => diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate
RHEA:54843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + octan-3-one <=> H2O + NADP(+) + pentyl propanoate
REACT:R-CEL-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Caenorhabditis elegans)
GO:0050026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity
GO:0050026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glycol:NAD(P)+ oxidoreductase activity
GO:0050026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glycol:NAD(P) dehydrogenase activity
GO:0050026	skos:prefLabel	"L-glycol dehydrogenase"
GO:0050026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glycol dehydrogenase"
GO:0050026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glycol dehydrogenase activity
GO:0050026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-(+)-glycol:NAD(P) oxidoreductase activity
REACT:R-HSA-1791169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of WFS1 (Homo sapiens)
REACT:R-DRE-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Danio rerio)
REACT:R-GGA-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Gallus gallus)
RHEA:25265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+)
REACT:R-SPO-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Schizosaccharomyces pombe)
RHEA:16772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)
REACT:R-BTA-265010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Bos taurus)
RHEA:65119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + aculene B + O2 <=> aculene A + CO2 + H2O + succinate
REACT:R-RNO-9634584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Rattus norvegicus)
EC:1.2.1.88	skos:altLabel	"1-pyrroline-5-carboxylate dehydrogenase"
EC:1.2.1.88	skos:altLabel	"pyrroline-5-carboxylate dehydrogenase"
EC:1.2.1.88	skos:prefLabel	"L-glutamate gamma-semialdehyde dehydrogenase"
EC:1.2.1.88	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glutamate gamma-semialdehyde dehydrogenase"
EC:1.2.1.88	skos:altLabel	"Delta(1)-pyrroline-5-carboxylate dehydrogenase"
RHEA:28755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + sn-glycerol 3-phosphate = a ubiquinol + dihydroxyacetone phosphate
REACT:R-SSC-399952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIMK-1 by PAK (Sus scrofa)
RHEA:23433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-4717521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates NR2C1 (TR2) (Homo sapiens)
REACT:R-MMU-8987043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22RA1 binds JAK1 (Mus musculus)
REACT:R-BTA-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Bos taurus)
RHEA:12707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine => [protein]-L-isoaspartate + S-adenosyl-L-methionine
RHEA:17407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine => N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine
RHEA:41904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)
REACT:R-HSA-193068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates PREG (Homo sapiens)
RHEA:72383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + urate(in) = Na(+)(in) + urate(out)
GO:0140597	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein chaperone
GO:0140597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein carrier activity
GO:0140597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein carrier chaperone
REACT:R-HSA-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Homo sapiens)
RHEA:70766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
GO:0031703	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 angiotensin receptor ligand
GO:0031703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 angiotensin receptor binding
GO:0031703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AT2 receptor binding
REACT:R-DDI-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Dictyostelium discoideum)
REACT:R-XTR-418442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Xenopus tropicalis)
RHEA:37887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide
RHEA:37887	skos:prefLabel	"small RNA 2'-O-methyltransferase"
RHEA:37887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"small RNA 2'-O-methyltransferase"
REACT:R-DDI-211988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Dictyostelium discoideum)
REACT:R-GGA-5694442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH2,3 bind GRIA1 (Gallus gallus)
REACT:R-SCE-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)
REACT:R-CFA-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Canis familiaris)
RHEA:52181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-9638125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G1P to G6P (Dictyostelium discoideum)
REACT:R-RNO-1234183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Rattus norvegicus)
REACT:R-MMU-4420117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR2 autophosphorylates (Mus musculus)
RHEA:45728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + H(+) + NADPH
REACT:R-DDI-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Dictyostelium discoideum)
REACT:R-CEL-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Caenorhabditis elegans)
REACT:R-DRE-977348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHGDH tetramer dehydrogenates 3PG (Danio rerio)
RHEA:22537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine
REACT:R-CEL-9605644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Caenorhabditis elegans)
RHEA:19778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + L-pipecolate => AH2 + H(+) + L-1-piperideine-6-carboxylate
RHEA:61597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbD protein]-dithiol + [thioredoxin]-disulfide => [DsbD protein]-disulfide + [thioredoxin]-dithiol
RHEA:61530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base
REACT:R-DME-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Drosophila melanogaster)
RHEA:52636	skos:prefLabel	"methylcytosine dioxygenase"
RHEA:52636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate
RHEA:52636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylcytosine dioxygenase"
GO:0047114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity
GO:0047114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity
GO:0047114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity
GO:0047114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenate-7,8-dihydrodiol dehydrogenase activity
GO:0004807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glyceraldehyde-3-phosphate ketol-isomerase activity
GO:0004807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triose phosphoisomerase activity
GO:0004807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triosephosphate mutase activity
GO:0004807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotriose isomerase activity
GO:0004807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity
GO:0004807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triose-phosphate isomerase activity
GO:0004807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triosephosphate isomerase activity
GO:0004807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triose phosphate mutase activity
GO:0030553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binding
GO:0030553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5' cGMP binding
GO:0030553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cGMP binding
GO:0030553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic GMP binding
RHEA:18261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"precorrin-6A synthase (deacetylating)"
RHEA:18261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + precorrin-5 + S-adenosyl-L-methionine = acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine
RHEA:18261	skos:altLabel	"precorrin-6X synthase (deacetylating)"
RHEA:18261	skos:prefLabel	"precorrin-6A synthase (deacetylating)"
RHEA:18653	skos:prefLabel	"barbiturase"
RHEA:18653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"barbiturase"
RHEA:18653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	barbiturate + H2O = 3-oxo-3-ureidopropanoate
REACT:R-DME-389652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Drosophila melanogaster)
RHEA:18062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran => methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin
RHEA:20859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + H2O <=> a fatty acid + sphing-4-enine
REACT:R-RNO-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Rattus norvegicus)
GO:0102714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12,oxoglutarate:oxygen oxidoreductase activity
RHEA:28383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine => D-glucose 6-phosphate + L-lysine
REACT:R-GGA-450292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Gallus gallus)
RHEA:13429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate
RHEA:13429	skos:altLabel	"MEP cytidylyltransferase"
RHEA:13429	skos:altLabel	"MCT"
RHEA:13429	skos:prefLabel	"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase"
RHEA:13429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase"
RHEA:13429	skos:altLabel	"4-diphosphocytidyl-2-C-methyl-D-erythritol synthase"
REACT:R-SPO-9635743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 binds p-T,Y-MAPK (Schizosaccharomyces pombe)
GO:0140837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain S7 kinase activity
REACT:R-SSC-373717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacts with DIP13alpha (Sus scrofa)
REACT:R-GGA-4720446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Gallus gallus)
RHEA:72915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructopyranose(out) + Na(+)(out) = D-fructopyranose(in) + Na(+)(in)
REACT:R-GGA-936942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Gallus gallus)
RHEA:15639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alginate](n+1) + GDP + H(+) => [alginate](n) + GDP-alpha-D-mannuronate
REACT:R-HSA-8877884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and FOXP3 stimulate the RSPO3 gene expression (Homo sapiens)
GO:0002151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-quadruplex RNA binding
GO:0002151	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	G-quartet binding
GO:0002151	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	G quartet binding
GO:0002151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G quartet RNA binding
GO:0002151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G quadruplex binding
REACT:R-HSA-203680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)
GO:0140107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity potassium ion transmembrane transporter activity
REACT:R-DRE-9626880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Danio rerio)
REACT:R-MMU-109539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Mus musculus)
REACT:R-RNO-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Rattus norvegicus)
REACT:R-HSA-2243942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT1 E17K mutant (Homo sapiens)
RHEA:48833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
RHEA:36513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-3-oxoicosenoyl-CoA + CO2 + CoA => (9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA
REACT:R-MMU-5251942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hikeshi binds HSP70s:ATP (Mus musculus)
RHEA:72580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O => (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA
REACT:R-RNO-3222237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMYD2 methylates TP53 (Rattus norvegicus)
RHEA:27671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1-phosphate + H2O => myo-inositol + phosphate
REACT:R-BTA-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)
RHEA:17906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NAD(+) => 3-hydroxypyruvate + H(+) + NADH
RHEA:51144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 = (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate
REACT:R-HSA-2404193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1R phosphorylates SHC1 (Homo sapiens)
REACT:R-SSC-381543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP4 binds IGF forming IGF:IGFBP4 (Sus scrofa)
RHEA:20158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] => an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)
RHEA:12910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome] + 2 H(+) + nitrate => 2 Fe(III)-[cytochrome] + H2O + nitrite
GO:0018559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
GO:0018559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity
REACT:R-SSC-2731122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2 & 4 bind VTN (Sus scrofa)
REACT:R-RNO-114552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate G12/13 (Rattus norvegicus)
REACT:R-SSC-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Sus scrofa)
REACT:R-DRE-349638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of SR-BI-bound spherical HDL (Danio rerio)
RHEA:42332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coenzyme gamma-F420-2:alpha-L-glutamate ligase"
RHEA:42332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + oxidized coenzyme F420-2 = ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate
RHEA:42332	skos:prefLabel	"coenzyme gamma-F420-2:alpha-L-glutamate ligase"
RHEA:14531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + phosphate => ADP + D-ribose 5-phosphate + H(+)
RHEA:66606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyuridine in double-stranded DNA + NH4(+) => a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O
RHEA:10530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
RHEA:33612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl salicylate => H(+) + methanol + salicylate
REACT:R-MMU-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
RHEA:60883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)
REACT:R-RNO-9700156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK dimer binds IRS1 (Rattus norvegicus)
REACT:R-BTA-8847995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERBB2 binds PTK6 (BRK) (Bos taurus)
RHEA:16306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA + H2O => 3-hydroxy-3-methylglutarate + CoA + H(+)
REACT:R-CFA-212706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipase C-gamma1 binds to the activated EGF receptor (Canis familiaris)
RHEA:37733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine
RHEA:52160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime = (Z)-phenylacetaldehyde oxime
RHEA:12467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + UDP-alpha-D-galactose <=> alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP
RHEA:36012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-RNO-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Rattus norvegicus)
RHEA:63684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP = (4R,5S)-dethiobiotin + ADP + H(+) + phosphate
RHEA:61812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose = dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP
GO:0009055	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	electron donor activity
GO:0009055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	electron transporter activity
GO:0009055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	electron carrier
GO:0009055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	electron transfer activity
GO:0009055	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	electron acceptor activity
RHEA:19645	skos:altLabel	"(2S,3R)-aldose dehydrogenase"
RHEA:19645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + H(+) + NADH
RHEA:19645	skos:prefLabel	"D-threo-aldose 1-dehydrogenase"
RHEA:19645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-threo-aldose 1-dehydrogenase"
RHEA:19645	skos:altLabel	"L-fucose dehydrogenase"
RHEA:10792	skos:altLabel	"5-phosphoribosyl-5-aminoimidazole carboxylase"
RHEA:10792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosylaminoimidazole carboxylase"
RHEA:10792	skos:altLabel	"5-amino-1-ribosylimidazole 5-phosphate carboxylase"
RHEA:10792	skos:altLabel	"5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase"
RHEA:10792	skos:altLabel	"AIR carboxylase"
RHEA:10792	skos:prefLabel	"phosphoribosylaminoimidazole carboxylase"
RHEA:10792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2
RHEA:10792	skos:altLabel	"1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase"
RHEA:40648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)
RHEA:63801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose => GDP-beta-L-gulose
REACT:R-CFA-9624526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Canis familiaris)
RHEA:19962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate => a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside
RHEA:13024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + vanillate <=> 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)
RHEA:66357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH
RHEA:42653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine => diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine
RHEA:68308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate
REACT:R-RNO-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Rattus norvegicus)
RHEA:53793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylthiol + O2 => benzothialdehyde + H2O2
REACT:R-DME-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Drosophila melanogaster)
GO:0062045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine alpha-aminotransferase
REACT:R-MMU-8987042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)
RHEA:54732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-GGA-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Gallus gallus)
RHEA:66540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + A + H2O = AH2 + cholesta-5,7-dien-3beta,25-diol
REACT:R-DDI-174202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Securin (Dictyostelium discoideum)
RHEA:45572	skos:altLabel	"alginate epimerase"
RHEA:45572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannuronosyl](n) = [alginate](n)
RHEA:45572	skos:altLabel	"C(5)-mannuronan epimerase"
RHEA:45572	skos:altLabel	"mannuronan C-5-epimerase"
RHEA:45572	skos:prefLabel	"mannuronan 5-epimerase"
RHEA:45572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannuronan 5-epimerase"
RHEA:11561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => catechol + CO2 + NADH
RHEA:66475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E,10E,14E)-geranylfarnesol <=> 18-episcalar-17(25)-en-19-ol
GO:1990655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 iron, 3 sulfur cluster binding
GO:1990655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4Fe-3S cluster binding
REACT:R-CEL-5689111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 autoubiquitinates (Caenorhabditis elegans)
RHEA:66874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Mus musculus)
REACT:R-BTA-8944220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIII (Bos taurus)
RHEA:56419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> alpha-D-glucose 1-phosphate + glycerol
REACT:R-MMU-158251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Mus musculus)
RHEA:48471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1b (d18:1(4E)) + H2O <=> ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate
RHEA:17168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-D-galactose
REACT:R-CFA-391151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47:SKAP2 binds FYB (Canis familiaris)
RHEA:56283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] <=> AMP + L-prolyl-[peptidyl-carrier protein]
REACT:R-CFA-5357432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL binds SRC-1 (Canis familiaris)
RHEA:51977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-seryl-[protein] + salicylate => acetylsalicylate + L-seryl-[protein]
GO:0102177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenelophenol methyl oxidase activity
REACT:R-HSA-2399988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates NR4A1 (NUR77) (Homo sapiens)
REACT:R-DRE-8937369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAD2 binds ESR1 (Danio rerio)
REACT:R-MMU-186798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binds to PDGF-beta receptors only (Mus musculus)
RHEA:45570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[acharan](n) => [heparosan](n)
RHEA:49373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protodeoxyviolaceinate => H2O + NAD(+) + protoviolaceinate
REACT:R-DRE-5672083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KTN1 binds Kinesin-1 (Danio rerio)
REACT:R-BTA-1067659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of hexameric IL-6 receptor (Bos taurus)
REACT:R-CEL-75883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHRS7B reduces GO3P to HXDG3P (Caenorhabditis elegans)
REACT:R-MMU-5635859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU dissociates (Mus musculus)
RHEA:48042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + N-acetyl-beta-D-galactosamine => globoside Gb4Cer + H2O
REACT:R-HSA-114275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BAX at the mitochondrial membrane (Homo sapiens)
REACT:R-DRE-110250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenoadenine by MPG glycosylase (Danio rerio)
RHEA:18795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate => alpha-D-ribose 1-phosphate
REACT:R-DME-5632652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds CDON and PTCH (Drosophila melanogaster)
REACT:R-HSA-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Homo sapiens)
GO:0050208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA:polysialic-acid O-acetyltransferase activity
GO:0050208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polysialic-acid O-acetyltransferase activity
RHEA:59109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + octyl beta-D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol
RHEA:52003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O
REACT:R-HSA-9025957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Homo sapiens)
REACT:R-CEL-9658445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Caenorhabditis elegans)
REACT:R-XTR-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Xenopus tropicalis)
REACT:R-HSA-6809263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)
REACT:R-DRE-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Danio rerio)
REACT:R-CFA-9645481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIFA oligomerization (Canis familiaris)
REACT:R-SPO-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Schizosaccharomyces pombe)
GO:0047679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine racemase activity
RHEA:51810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)
RHEA:25816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + norspermine + O2 = 3-aminopropanal + H2O2 + norspermidine
REACT:R-BTA-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Bos taurus)
RHEA:61774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + rebaudioside D + UDP => rebaudioside E + UDP-alpha-D-glucose
REACT:R-DME-5252041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Drosophila melanogaster)
RHEA:71851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate(out) = glycocholate(in)
REACT:R-XTR-8877620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE2 cleaves EDN1(53-90) (Xenopus tropicalis)
RHEA:37170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + NAD(+) <=> (2E,6E)-farnesal + H(+) + NADH
REACT:R-RNO-2160851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAS1,2,3 mediate the polymerisation of HA (Rattus norvegicus)
RHEA:46802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:61929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-miconazole(in) + ATP + H2O => (R)-miconazole(out) + ADP + H(+) + phosphate
REACT:R-HSA-5218809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)
REACT:R-MMU-373738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin interacts with syntenin-1 (Mus musculus)
REACT:R-RNO-193533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)
REACT:R-DME-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Drosophila melanogaster)
REACT:R-MMU-183130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Mus musculus)
REACT:R-CEL-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Caenorhabditis elegans)
RHEA:53790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholate + beta-muricholoyl-CoA => allodeoxycholoyl-CoA + beta-muricholate
REACT:R-HSA-72185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA polyadenylation (Homo sapiens)
RHEA:36396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + NADP(+) => 7-dehydrodesmosterol + H(+) + NADPH
REACT:R-DDI-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Dictyostelium discoideum)
RHEA:14298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-galactose
RHEA:10148	skos:prefLabel	"blasticidin-S deaminase"
RHEA:10148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"blasticidin-S deaminase"
RHEA:10148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	blasticidin S + H(+) + H2O = deaminohydroxyblasticidin S + NH4(+)
REACT:R-CFA-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Canis familiaris)
REACT:R-DME-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-SPO-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Schizosaccharomyces pombe)
REACT:R-BTA-9603419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds SRC (Bos taurus)
REACT:R-MMU-166175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Mus musculus)
RHEA:46054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine => a 3'-end uridylyl-uridine-RNA
REACT:R-HSA-2533970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NID1 degradation by MMP3, 7 (Homo sapiens)
RHEA:58198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-lysyl-[histone] => H2O + N(6)-acetyl-L-lysyl-[histone]
REACT:R-HSA-5665659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP:FMNL1 binds profilin:G-actin (Homo sapiens)
REACT:R-CFA-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Canis familiaris)
RHEA:71243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + hypotaurine(out) + 2 Na(+)(out) = chloride(in) + hypotaurine(in) + 2 Na(+)(in)
REACT:R-HSA-9669900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT mutants bind type II TKIs (Homo sapiens)
RHEA:47798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => an aralkylamine + H2O + 2 oxidized [azurin]
REACT:R-DDI-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)
RHEA:38441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol
REACT:R-DRE-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Danio rerio)
REACT:R-CFA-8937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)
GO:0042913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	group A colicin transmembrane transporter activity
RHEA:38612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) => cyclic ADP-beta-D-ribose + H(+) + nicotinamide
REACT:R-HSA-9025996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Homo sapiens)
EC:3.4.2.-	skos:prefLabel	"Peptidyl-amino-acid hydrolases"
EC:3.4.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Peptidyl-amino-acid hydrolases"
REACT:R-HSA-8848776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates DOK1 (Homo sapiens)
REACT:R-SSC-5696945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates CCP110,ARRB (Sus scrofa)
REACT:R-MMU-1655851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2P hydrolyzes SREBP1A,1C,2 (Mus musculus)
REACT:R-MMU-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Mus musculus)
GO:0120250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0120250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid omega-hydroxylase activity
REACT:R-DDI-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Dictyostelium discoideum)
RHEA:27789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CoA + NAD(+) <=> CO2 + NADH + succinyl-CoA
RHEA:44938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate => (9Z,12Z,15Z)-octadecatrienoate + ATP + CoA
REACT:R-CEL-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Caenorhabditis elegans)
REACT:R-DRE-266310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:spherical HDL complex <=> LCAT + spherical HDL (Danio rerio)
REACT:R-SSC-9646348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Sus scrofa)
RHEA:26349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-galactose 1-phosphate + H2O = L-galactose + phosphate
RHEA:26349	skos:prefLabel	"L-galactose 1-phosphate phosphatase"
RHEA:26349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-galactose 1-phosphate phosphatase"
EC:4.1.2.48	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"low-specificity L-threonine aldolase"
EC:4.1.2.48	skos:prefLabel	"low-specificity L-threonine aldolase"
RHEA:52193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Bos taurus)
RHEA:41350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-RNO-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Rattus norvegicus)
REACT:R-HSA-8950684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Heterogeneous nuclear ribonucleoprotein D-like (Homo sapiens)
RHEA:44627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH
RHEA:60304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:67507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:58630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV
REACT:R-HSA-2730863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 by PKC-theta (Homo sapiens)
REACT:R-DDI-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Dictyostelium discoideum)
RHEA:53847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate + NAD(+) <=> 7-oxoglycolithocholate + H(+) + NADH
RHEA:35219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dADP + H2O = 8-oxo-dAMP + H(+) + phosphate
REACT:R-BTA-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Bos taurus)
REACT:R-SSC-446692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 binds to MYD88 within the IL1R complex (Sus scrofa)
RHEA:41710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O
RHEA:67967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylamino-L-phenylalanine + S-adenosyl-L-methionine <=> 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-8950269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Homo sapiens)
REACT:R-DDI-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Dictyostelium discoideum)
REACT:R-MMU-173636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of classic pathway C5 convertase (Mus musculus)
REACT:R-XTR-202203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PI3K to plasma membrane (Xenopus tropicalis)
REACT:R-HSA-5686315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Homo sapiens)
REACT:R-DRE-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Danio rerio)
REACT:R-HSA-8956050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Homo sapiens)
RHEA:59707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellohexaono-1,5-lactone + H2O <=> D-cellohexaonate + H(+)
REACT:R-BTA-6810239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)
RHEA:72900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-demethylbarbatate + S-adenosyl-L-methionine => proatranorin I + S-adenosyl-L-homocysteine
GO:0102460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity
RHEA:12299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylipecoside + H2O <=> dopamine + secologanin
RHEA:56498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gypsogenin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:23145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-D-glucosamine + NAD(+) => 2 H(+) + N-acetyl-D-glucosaminate + NADH
REACT:R-RNO-388808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-2 monomer (Rattus norvegicus)
REACT:R-CFA-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)
REACT:R-CEL-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Caenorhabditis elegans)
RHEA:48439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pentanoate ester <=> an aliphatic alcohol + H(+) + pentanoate
RHEA:62055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)
REACT:R-RNO-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Rattus norvegicus)
REACT:R-HSA-4641350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TOP2A with SUMO2,3 (Homo sapiens)
RHEA:41206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:17718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkappaB kinase activity
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CHUK
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inhibitor of NF-kappaB kinase activity
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TBK1
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TANK-binding kinase 1 activity
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IKBKA
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inhibitor of NFkappaB kinase activity
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IKBKB
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK12
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IKK-2
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:IkappaB protein phosphotransferase activity
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IKK-1
GO:0008384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IKK
REACT:R-RNO-8854899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Rattus norvegicus)
REACT:R-RNO-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Rattus norvegicus)
RHEA:20177	skos:prefLabel	"pyridoxine 5'-O-beta-D-glucosyltransferase"
RHEA:20177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine + UDP-alpha-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP
RHEA:20177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxine 5'-O-beta-D-glucosyltransferase"
RHEA:20177	skos:altLabel	"UDP-glucose-pyridoxine glucosyltransferase"
REACT:R-MMU-1855159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Mus musculus)
REACT:R-BTA-420591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-2:Nectin 3 trans heterodimer interaction (Bos taurus)
REACT:R-HSA-8950591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)
GO:0047460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-amino-4-chloro-4-pentenoate dehalogenase activity
GO:0047460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)
GO:0047460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)
GO:0047460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity
REACT:R-HSA-399934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Plexin-A (Homo sapiens)
REACT:R-HSA-448708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)
RHEA:22427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-alkyl-L-cysteine + H2O <=> an alkyl thiol + NH4(+) + pyruvate
RHEA:16177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH
RHEA:16177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate
RHEA:16177	skos:prefLabel	"retinal dehydrogenase"
RHEA:16177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"retinal dehydrogenase"
RHEA:52239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin b
REACT:R-BTA-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Bos taurus)
REACT:R-CFA-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Canis familiaris)
RHEA:40147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+)
REACT:R-CFA-389986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Canis familiaris)
RHEA:47959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-maleylpyruvate + H2O <=> H(+) + maleate + pyruvate
REACT:R-DDI-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)
REACT:R-HSA-202917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 1 (Homo sapiens)
REACT:R-CFA-5654515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds HS (Canis familiaris)
REACT:R-HSA-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
REACT:R-CFA-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Canis familiaris)
RHEA:34549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate + H2O + L-glutamine
REACT:R-RNO-1564142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV degradation by MMP2,3,4,9,10,12 (Rattus norvegicus)
REACT:R-BTA-8849435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 dephosphorylates PTK6 (Bos taurus)
REACT:R-GGA-8985914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Gallus gallus)
RHEA:22148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plastoquinol--plastocyanin reductase"
RHEA:22148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] = a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]
RHEA:22148	skos:altLabel	"cytochrome b6f complex"
RHEA:22148	skos:prefLabel	"plastoquinol--plastocyanin reductase"
GO:0042879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldonate transmembrane transporter activity
RHEA:41598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH
RHEA:37805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA
REACT:R-CFA-166538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The bound receptor dimerizes (Canis familiaris)
REACT:R-DRE-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Danio rerio)
REACT:R-GGA-1433454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GAB2 by SFKs (Gallus gallus)
REACT:R-GGA-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Gallus gallus)
REACT:R-BTA-8853737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Bos taurus)
REACT:R-HSA-9694487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M protein oligomerization (Homo sapiens)
RHEA:63070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 3 CoA + triacetate lactone => acetyl-CoA + 2 H(+) + 2 malonyl-CoA
REACT:R-DRE-192157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
RHEA:17518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(long-chain-fatty-acyl)-L-glutamate => a long-chain fatty acid + L-glutamate
RHEA:60163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + vincristine(in) <=> ADP + H(+) + phosphate + vincristine(out)
RHEA:42506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-acetamido-2-oxohexanoate + L-glutamate => 2-oxoglutarate + N(6)-acetyl-L-lysine
REACT:R-GGA-5669012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA binds EDAR (Gallus gallus)
REACT:R-RNO-5663050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHI and DHICA polymerise forming eumelanin (Rattus norvegicus)
REACT:R-DRE-210881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Tie2/Ang1 complex (Danio rerio)
REACT:R-CEL-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Caenorhabditis elegans)
RHEA:36463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamate + H2O = glycine + L-glutamate
RHEA:25166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + AH2 => A + butanoyl-CoA
GO:0001621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled ADP receptor activity
GO:0001621	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ADP receptor activity
GO:0001621	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ADP-activated nucleotide receptor activity
GO:0001621	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	K101 receptor
GO:0001621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-activated adenosine receptor activity
GO:0001621	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	platelet ADP receptor activity
RHEA:58180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + diphosphate + NADP(+)
RHEA:39012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol(in) => a triacyl-sn-glycerol(out)
RHEA:25518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + O-acyltropine => an acyl-CoA + tropine
REACT:R-MMU-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Mus musculus)
REACT:R-RNO-6801776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A binds bacterial phospholipids (Rattus norvegicus)
RHEA:35295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-molybdopterin + H(+) + tungstate = AMP + H2O + W-molybdopterin cofactor
RHEA:68455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-10'-apo-beta-carotenal + O2 <=> 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone
REACT:R-SSC-2130500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of MHC II:Ii complex in to the plasma membrane (Sus scrofa)
REACT:R-CFA-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Canis familiaris)
REACT:R-XTR-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)
RHEA:19865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III
RHEA:19865	skos:altLabel	"uroporphyrinogen-III carboxy-lyase"
RHEA:19865	skos:altLabel	"uroporphyrinogen III decarboxylase"
RHEA:19865	skos:prefLabel	"uroporphyrinogen decarboxylase"
RHEA:19865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uroporphyrinogen decarboxylase"
RHEA:37667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP
RHEA:37667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase"
RHEA:37667	skos:prefLabel	"protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase"
GO:0032031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin I head/neck binding
REACT:R-MMU-400143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fatty acid ligands activate PPARA (Mus musculus)
RHEA:29050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+)(in) + H2 <=> a menaquinol + 2 H(+)(out)
REACT:R-XTR-9605700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Xenopus tropicalis)
REACT:R-CFA-5656064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FLRT1,2,3 (Canis familiaris)
RHEA:42990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cembrene C + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
RHEA:49836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5E)-tetradecenoyl-CoA + (R)-carnitine = (5E)-tetradecenoyl-(R)-carnitine + CoA
RHEA:23194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-SSC-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Sus scrofa)
REACT:R-MMU-174959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT1 (Mus musculus)
RHEA:17434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + choline => AH2 + betaine aldehyde
RHEA:65289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine
REACT:R-GGA-451461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)
REACT:R-SSC-190782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of connexon-containing transport vesicles from the Golgi (Sus scrofa)
GO:0016443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bidentate RNase III activity
GO:0016443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bidentate ribonuclease III activity
RHEA:72238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) <=> 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)
REACT:R-CFA-77299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Canis familiaris)
RHEA:34845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromonapterin + 2 H(+) + 3 phosphate => 7,8-dihydromonapterin 3'-triphosphate + 3 H2O
REACT:R-PFA-9020273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Plasmodium falciparum)
GO:0062179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin D 23-hydroxylase activity
RHEA:44942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O
REACT:R-MMU-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Mus musculus)
RHEA:65223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + H(+) + NADPH
REACT:R-GGA-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Gallus gallus)
RHEA:12718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
RHEA:14151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP => luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate
REACT:R-BTA-444773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-TM7 receptors bind chondroitin sulphate (Bos taurus)
RHEA:40422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phytanoyl-CoA <=> 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)
GO:0030552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-cyclophosphate binding
GO:0030552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic AMP binding
GO:0030552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5' cAMP binding
GO:0030552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binding
GO:0030552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cAMP binding
REACT:R-SPO-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Schizosaccharomyces pombe)
REACT:R-HSA-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Homo sapiens)
REACT:R-MMU-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Mus musculus)
RHEA:34654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-983421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Journey of cargo through Golgi complex (Xenopus tropicalis)
REACT:R-HSA-9647619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD forms ring‐shaped oligomers  (Homo sapiens)
REACT:R-HSA-6788707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT44 2'-O-methylates uridine-44 in tRNA(Ser) (Homo sapiens)
RHEA:20029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine
RHEA:20029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vellosimine dehydrogenase"
RHEA:20029	skos:prefLabel	"vellosimine dehydrogenase"
RHEA:51730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone + phosphate => dihydroxyacetone phosphate + H2O
GO:0033919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan 1,3-alpha-glucosidase activity
GO:0033919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,3-alpha-glucanase activity
GO:0033919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-alpha-D-glucan 3-glucohydrolase activity
REACT:R-RNO-9735946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET small tyrosine kinase inhibitors bind MET (Rattus norvegicus)
RHEA:37067	skos:altLabel	"2-methylthio-N-6-isopentenyl adenosine synthase"
RHEA:37067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase"
RHEA:37067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
RHEA:37067	skos:altLabel	"tRNA-i6A37 methylthiotransferase"
RHEA:37067	skos:prefLabel	"tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase"
RHEA:54075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> beta-thujene + diphosphate
GO:0047572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-phosphoglycerate phosphatase activity
GO:0047572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-PGA phosphatase activity
GO:0047572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glycerate-3-phosphate phosphohydrolase activity
GO:0047572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoglycerate phosphatase activity
REACT:R-SPO-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)
REACT:R-CFA-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Canis familiaris)
RHEA:55580	skos:prefLabel	"glutamine kinase"
RHEA:55580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamine kinase"
RHEA:55580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine = AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate
REACT:R-CFA-5672948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK3 phosphorylates KSR1 (Canis familiaris)
REACT:R-SSC-9706350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates CBL (Sus scrofa)
REACT:R-SSC-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Sus scrofa)
GO:0045512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-26 binding
GO:0045512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-26 binding
REACT:R-MMU-400183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA:RXRA binds Corepressors of PPARA (Mus musculus)
REACT:R-MMU-9014454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG translocates to the ER membrane (Mus musculus)
RHEA:66040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SSC-159836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)
REACT:R-CEL-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Caenorhabditis elegans)
REACT:R-CEL-9731661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)
REACT:R-CFA-6799178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 1 binds HP subcomplex to form Intermediate 2 (Canis familiaris)
REACT:R-DRE-8852874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 binds C3d, C3dg, iC3b (Danio rerio)
REACT:R-DDI-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Dictyostelium discoideum)
REACT:R-HSA-202702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD177 binds PECAM-1 (Homo sapiens)
RHEA:17650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + malonate => acetate + malonyl-[ACP]
REACT:R-BTA-5686359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPs translocate from extracellular region to clathrin-coated vesicle (Bos taurus)
REACT:R-GGA-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Gallus gallus)
REACT:R-SSC-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Sus scrofa)
EC:3.1.27.7	skos:altLabel	"RNase F"
EC:3.1.27.7	skos:prefLabel	"ribonuclease F"
EC:3.1.27.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease F"
REACT:R-HSA-374298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid receptors bind opioid peptides (Homo sapiens)
RHEA:30791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + pyruvate = dGDP + H(+) + phosphoenolpyruvate
RHEA:33506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + itraconazole(in) <=> ADP + H(+) + itraconazole(out) + phosphate
RHEA:36364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH => (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)
RHEA:53940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-445813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Smooth Muscle Myosin Light Chains (Canis familiaris)
REACT:R-HSA-8866321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL binds APOC1 and APOC4 (Homo sapiens)
RHEA:62603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate
REACT:R-HSA-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Homo sapiens)
REACT:R-CFA-205234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of GAB2 to p-KIT (Canis familiaris)
REACT:R-XTR-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Xenopus tropicalis)
RHEA:20187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylneuraminate + CMP + H(+) => a CMP-N-acyl-beta-neuraminate + H2O
RHEA:73000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] => L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]
REACT:R-GGA-2243931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-lysinonorleucine cross-links (Gallus gallus)
RHEA:16480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADH
REACT:R-HSA-975916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 5 by MGAT5 (Homo sapiens)
REACT:R-SPO-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Schizosaccharomyces pombe)
REACT:R-CEL-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-BTA-173636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of classic pathway C5 convertase (Bos taurus)
REACT:R-CFA-9705738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Canis familiaris)
REACT:R-CFA-8875531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS4 (Canis familiaris)
RHEA:57402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + narcotine hemiacetal => 3-O-acetylpapaveroxine + H2O
REACT:R-HSA-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Homo sapiens)
REACT:R-DME-77594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Drosophila melanogaster)
REACT:R-SSC-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Sus scrofa)
REACT:R-CFA-3149494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC:cob(II)alamin binds MMADHC (Canis familiaris)
REACT:R-CFA-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Canis familiaris)
RHEA:62572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine = glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine
REACT:R-HSA-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Homo sapiens)
RHEA:39776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Canis familiaris)
REACT:R-MMU-6803753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAAA hydrolyses NAEs to FAs and ethanolamine (Mus musculus)
RHEA:20652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23,24-dihydrocucurbitacin B + NADP(+) <=> cucurbitacin B + H(+) + NADPH
REACT:R-GGA-140825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Gallus gallus)
RHEA:14560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + raucaffricine <=> D-glucose + vomilenine
REACT:R-DME-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Drosophila melanogaster)
REACT:R-HSA-420593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR:PVRL3 trans heterodimer interaction (Homo sapiens)
REACT:R-XTR-2395879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
RHEA:37917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol
RHEA:50095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + taurine <=> an N-fatty acyl-taurine + CoA + H(+)
REACT:R-RNO-69299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds geminin (Rattus norvegicus)
REACT:R-CFA-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Canis familiaris)
REACT:R-SSC-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Sus scrofa)
REACT:R-SSC-192312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Sus scrofa)
RHEA:40841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-nonenoyl-CoA + FADH2 => FAD + H(+) + nonanoyl-CoA
REACT:R-BTA-9603983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeX to form LeY (Bos taurus)
REACT:R-CFA-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Canis familiaris)
GO:0120204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity
RHEA:32429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carvone + AH2 => (1R,4S)-isodihydrocarvone + A
RHEA:43125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(10) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine
RHEA:17822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen cyanide + L-cysteine => 3-cyano-L-alanine + H(+) + hydrogen sulfide
REACT:R-DRE-177939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
RHEA:53179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)
RHEA:49879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Rattus norvegicus)
RHEA:31535	skos:prefLabel	"2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)"
RHEA:31535	skos:altLabel	"ethylene-forming enzyme"
RHEA:31535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginine + O2 = (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate
RHEA:31535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)"
RHEA:47498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5beta-cholan-24-oate + H(+) + NADPH => lithocholate + NADP(+)
RHEA:59858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine => Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium
REACT:R-RNO-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Rattus norvegicus)
EC:3.4.18.1	skos:altLabel	"acid carboxypeptidase"
EC:3.4.18.1	skos:altLabel	"cathepsin B2"
EC:3.4.18.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin X"
EC:3.4.18.1	skos:altLabel	"cysteine-type carboxypeptidase"
EC:3.4.18.1	skos:prefLabel	"cathepsin X"
EC:3.4.18.1	skos:altLabel	"lysosomal carboxypeptidase B"
EC:3.4.18.1	skos:altLabel	"cathepsin Z"
EC:3.4.18.1	skos:altLabel	"cathepsin IV"
REACT:R-XTR-5357831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD is phosphorylated by IKK (Xenopus tropicalis)
RHEA:17223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O => dTDP-alpha-D-glucose
REACT:R-HSA-9618559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene (Homo sapiens)
REACT:R-HSA-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Homo sapiens)
REACT:R-SCE-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Saccharomyces cerevisiae)
RHEA:68175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 <=> CO2 + H2O + isodomoate A + succinate
REACT:R-HSA-9625548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride (Homo sapiens)
REACT:R-HSA-8949276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3:CBFB binds the RORC gene promoter (Homo sapiens)
REACT:R-HSA-445087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHL1 interacts with HSP7C (Homo sapiens)
RHEA:51910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dADP + H(+) + phosphate => dATP + H2O
REACT:R-CFA-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Canis familiaris)
REACT:R-DRE-3240295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Danio rerio)
REACT:R-RNO-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Rattus norvegicus)
REACT:R-HSA-2076419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Homo sapiens)
RHEA:24844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,3-alpha-isomaltosidase"
RHEA:24844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O = 2 isomaltose
RHEA:24844	skos:prefLabel	"1,3-alpha-isomaltosidase"
REACT:R-GGA-936951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to activated TLR4 complex (Gallus gallus)
REACT:R-BTA-5205682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin promotes the ubiquitination of mitochondrial substrates (Bos taurus)
REACT:R-XTR-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Xenopus tropicalis)
RHEA:70035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol
REACT:R-SPO-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Schizosaccharomyces pombe)
RHEA:37323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-methionine + H2O = glycine + L-methionine
REACT:R-MMU-8964340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq-BTK complex dissociates to Active BTK and Gq (Mus musculus)
RHEA:52649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arabino-1,4-lactone 5-phosphate => 5-phospho-L-arabinonate + H(+)
REACT:R-CFA-5684006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translocates NBN to the nucleus (Canis familiaris)
REACT:R-DRE-8849646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK5(490-624) binds KLK5 (Danio rerio)
REACT:R-CFA-5607726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)
REACT:R-SSC-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Sus scrofa)
REACT:R-MMU-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Mus musculus)
RHEA:59832	skos:altLabel	"fructosamine 3-kinase"
RHEA:59832	skos:prefLabel	"protein-fructosamine 3-kinase"
RHEA:59832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-fructosamine 3-kinase"
RHEA:59832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]
RHEA:48345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + UDP-alpha-D-galactose => a D-galactosylceramide + H(+) + UDP
RHEA:56657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH
RHEA:41794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + malonyl-[ACP] => holo-[ACP] + malonyl-CoA
REACT:R-HSA-8938231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds CREBBP (Homo sapiens)
REACT:R-MMU-445752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Mus musculus)
REACT:R-GGA-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Gallus gallus)
REACT:R-XTR-9611852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB3 bind ADR,NAd (Xenopus tropicalis)
REACT:R-HSA-9629245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 D132V does not cleave 5-guanidinohydantoin (Gh) (Homo sapiens)
REACT:R-DDI-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Dictyostelium discoideum)
REACT:R-XTR-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Xenopus tropicalis)
RHEA:61151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP
RHEA:47470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-tetradecadienoyl-CoA => (2E,4E)-tetradecadienoyl-CoA
GO:0106364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity
GO:0106364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:49269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]
REACT:R-XTR-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:57923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) <=> H(+) + L-asparaginyl-tRNA(Asn) + phosphate
REACT:R-CFA-8869603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A13 transports NCA from extracellular region to cytosol (Canis familiaris)
REACT:R-CFA-8863804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)
RHEA:18712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + taurine <=> AH2 + NH4(+) + sulfoacetaldehyde
REACT:R-HSA-9647977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT methylates S-Farn RAS proteins (Homo sapiens)
RHEA:11841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H2O + NAD(+) => benzoate + 2 H(+) + NADH
REACT:R-RNO-9647643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds bacterial cardiolipin (Rattus norvegicus)
GO:0008970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase A1 activity
GO:0008970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine 1-acylhydrolase activity
REACT:R-SSC-8987080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Sus scrofa)
REACT:R-BTA-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Bos taurus)
EC:2.4.1.207	skos:altLabel	"xyloglucan endotransglycosylase"
EC:2.4.1.207	skos:altLabel	"endo-xyloglucan transferase"
EC:2.4.1.207	skos:prefLabel	"xyloglucan:xyloglucosyl transferase"
EC:2.4.1.207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xyloglucan:xyloglucosyl transferase"
REACT:R-MMU-8853737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Mus musculus)
REACT:R-MMU-9021600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-proteins dissociate from plasma-membrane estrogen receptors (Mus musculus)
REACT:R-SCE-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Saccharomyces cerevisiae)
REACT:R-HSA-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Homo sapiens)
REACT:R-HSA-1168809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS binding to GHR (Homo sapiens)
REACT:R-HSA-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Homo sapiens)
REACT:R-MMU-5654416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:pFRS binds GRB2:SOS1 (Mus musculus)
REACT:R-DRE-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Danio rerio)
REACT:R-HSA-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Homo sapiens)
REACT:R-RNO-2730844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GRB2:SOS complex with p-SHC1 (Rattus norvegicus)
REACT:R-SSC-6801666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates CENPJ (Sus scrofa)
REACT:R-SSC-3257122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Sus scrofa)
REACT:R-SSC-2534359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CatSper Channel Mediated Calcium Transport (Sus scrofa)
GO:0005010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF receptor activity
GO:0005010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin-like growth factor receptor activity
GO:0005010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF-activated receptor activity
GO:0005010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin-like growth factor-activated receptor activity
RHEA:42463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzofuran + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + NAD(+)
REACT:R-XTR-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Xenopus tropicalis)
REACT:R-DRE-2187330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)
REACT:R-DME-77301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Drosophila melanogaster)
GO:0070087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromoshadow domain binding
GO:0070087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromo shadow domain binding
REACT:R-DRE-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Danio rerio)
REACT:R-CFA-1855162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Canis familiaris)
REACT:R-SPO-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Schizosaccharomyces pombe)
RHEA:33719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)
REACT:R-SSC-8875591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK7 activates RAC1 (Sus scrofa)
REACT:R-CFA-9759549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Canis familiaris)
REACT:R-GGA-159868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor VII to factor VII (Gallus gallus)
RHEA:11087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + H(+) <=> CO2 + L-xylulose
RHEA:66090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate => L-kynurenine + oxaloacetate
RHEA:61326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:57500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O
RHEA:57690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)inamide-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)inamide
RHEA:56202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose
REACT:R-MMU-5655170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 monoubiquitinates POLH (Mus musculus)
REACT:R-HSA-266350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP-mediated lipid exchange: LDL gains cholesterol ester (Homo sapiens)
REACT:R-HSA-198813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO dimers reduce DeHA to AscH- (Homo sapiens)
RHEA:35843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin
REACT:R-HSA-1791130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CTDSP2 (Homo sapiens)
REACT:R-DME-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Drosophila melanogaster)
RHEA:67902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + succinate => glutarate + succinyl-CoA
GO:1904841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC 2 complex binding
GO:1904841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex binding
GO:1904841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 binding
GO:1904841	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mTORC2 binding
GO:1904841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rapamycin and nutrient-insensitive TOR complex binding
GO:1904841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOR complex 2 binding
REACT:R-HSA-9010872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 binds Dystroglycan (Homo sapiens)
REACT:R-RNO-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Rattus norvegicus)
RHEA:24501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-tetraphosphate + H2O => ATP + H(+) + phosphate
RHEA:11136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)
RHEA:11919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) <=> 15-oxoprostaglandin E2 + H(+) + NADH
RHEA:47714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-3-hydroxy-D-proline => trans-3-hydroxy-L-proline
RHEA:44434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + glycerol => 2 a 1-acylglycerol
REACT:R-RNO-5696838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Rattus norvegicus)
REACT:R-SPO-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Schizosaccharomyces pombe)
EC:2.1.5.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sesamin methylene transferase"
EC:2.1.5.1	skos:prefLabel	"sesamin methylene transferase"
RHEA:46660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + progesterone = 5beta-pregnan-3,20-dione + NADP(+)
RHEA:37782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:40836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine
RHEA:17942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O
RHEA:55785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate => all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP
REACT:R-BTA-5682826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM11 (Bos taurus)
GO:0001608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled nucleotide receptor activity
GO:0001608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled nucleotide receptor activity
GO:0001608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide receptor activity, G protein coupled
GO:0001608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled nucleotide receptor activity
GO:0001608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide receptor activity, G-protein coupled
REACT:R-SSC-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Sus scrofa)
RHEA:71388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate(in) + Na(+)(in) => L-pipecolate(out) + Na(+)(out)
RHEA:36314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + H2O + NAD(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADH
RHEA:41218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)
REACT:R-DRE-3782655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC10 deacetylates histone (Danio rerio)
REACT:R-MMU-4088218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetrastatin binds integrin alphaVbeta3 (Mus musculus)
REACT:R-BTA-9008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37, IL37(?-218) translocates from cytosol to extracellular region (Bos taurus)
RHEA:32205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + methylamine => (R)-synephrine
GO:0052674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-9(11),15-diene-forming] activity
GO:0052674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-pimara-9(11),15-diene synthase activity
GO:0052674	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PMD synthase activity
RHEA:68166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SPO-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)
REACT:R-SSC-2395314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysino-5-ketonorleucine cross-links (Sus scrofa)
REACT:R-CFA-163214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)
RHEA:25599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate
RHEA:14512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + mugineate + O2 <=> 3-epihydroxymugineate + CO2 + H(+) + succinate
GO:0015116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate transmembrane transporter activity
GO:0015116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfate permease activity
GO:0015116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphate transporter activity
REACT:R-RNO-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Rattus norvegicus)
REACT:R-XTR-9684068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD binds cardiac glycosides (Xenopus tropicalis)
RHEA:13745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascopyrone M = microthecin
REACT:R-XTR-5607725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Xenopus tropicalis)
REACT:R-DME-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Drosophila melanogaster)
RHEA:67455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O <=> 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)
RHEA:50558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin J2 => prostaglandin D2
RHEA:50775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nitroethane + O2 <=> acetaldehyde + H(+) + H2O2 + nitrite
REACT:R-MMU-983424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of COPII coated vesicle (Mus musculus)
RHEA:65590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]
EC:3.4.24.32	skos:prefLabel	"beta-lytic metalloendopeptidase"
EC:3.4.24.32	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-lytic metalloendopeptidase"
EC:3.4.24.32	skos:altLabel	"achromopeptidase component"
EC:3.4.24.32	skos:altLabel	"Myxobacter beta-lytic proteinase"
RHEA:35257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + lipid A-core(out) + phosphate => ATP + H2O + lipid A-core(in)
REACT:R-DME-9654523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP bind PDE6D on KRAS4B (Drosophila melanogaster)
RHEA:37560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-RNO-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Rattus norvegicus)
RHEA:62338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3'-diphosphate,5'-phosphate + AMP + H(+) => AMP + ATP
REACT:R-CFA-5653766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)
RHEA:67842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid IVA + ADP + H(+) => a lipid A disaccharide + ATP
REACT:R-HSA-2454208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)
REACT:R-RNO-606349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mis18 complex binds the centromere (Rattus norvegicus)
RHEA:72753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + ochratoxin alpha => H2O + ochratoxin A
REACT:R-CFA-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Canis familiaris)
REACT:R-DRE-8964280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Gq binds BTK (Danio rerio)
REACT:R-DDI-9638076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from small HA fragments (Dictyostelium discoideum)
RHEA:59584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-lysine = ADP + beta-alanyl-L-lysine + H(+) + phosphate
RHEA:65257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + verruculide C => A + H2O + verruculide C epoxide
REACT:R-HSA-3656258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ST3GAL3 does not transfer SA to keratan (Homo sapiens)
REACT:R-BTA-937032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
RHEA:42156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone + H(+) + NADPH = 5alpha-androstane-3alpha,17beta-diol + NADP(+)
RHEA:31625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine => L-olivosyl-oleandolide + S-adenosyl-L-methionine
RHEA:28132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baicalein + D-glucuronate + H(+) => baicalin + H2O
REACT:R-HSA-2530429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of soluble VTN:C5b-C9  (Homo sapiens)
REACT:R-SSC-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Sus scrofa)
RHEA:28665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + D-glucose => H2O + melibiose
GO:0034890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endosulfan diol hydrolyase (cyclizing) activity
REACT:R-GGA-964759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alternative endo-mannosidase I route (Gallus gallus)
RHEA:20925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [peptide]-C-terminal (2S)-2-hydroxyglycine => a [peptide]-C-terminal amide + glyoxylate
RHEA:12251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + UDP-N-acetyl-alpha-D-muramate <=> H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
RHEA:72348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole => 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
RHEA:51489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaetidylserine + H(+) => archaetidylethanolamine + CO2
REACT:R-CEL-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Caenorhabditis elegans)
REACT:R-HSA-8937767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 dephosphorylates RUNX1 (Homo sapiens)
REACT:R-HSA-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Homo sapiens)
RHEA:38634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:47623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethylhexyl sulfate + 2-oxoglutarate + O2 <=> 2-ethylhexanal + CO2 + H(+) + succinate + sulfate
GO:0031786	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1B melatonin receptor ligand
GO:0031786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1B melatonin receptor binding
GO:0050010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity
GO:0050010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovitexin beta-glucosyltransferase activity
GO:0050010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity
GO:0050010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity
GO:0050010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovitexin b-glucosyltransferase activity
REACT:R-SCE-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Saccharomyces cerevisiae)
RHEA:29017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) + sn-glycerol 3-phosphate(out) => phosphate(out) + sn-glycerol 3-phosphate(in)
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNase H1 activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoribonuclease H
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hybridase activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease H activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endoribonuclease0 H activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hybrid nuclease activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-DNA hybrid ribonuclease activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNase H2 activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoribonuclease H (calf thymus)
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNase H3 activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hybrid ribonuclease activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ribonuclease H1 activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hybridase (ribonuclease H)
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ribonuclease H2 activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA*DNA hybrid ribonucleotidohydrolase activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calf thymus ribonuclease H activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase H activity
GO:0004523	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ribonuclease H3 activity
REACT:R-SSC-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Sus scrofa)
RHEA:64099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] <=> 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]
RHEA:46614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol
REACT:R-DRE-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Danio rerio)
GO:0050161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalate CoA-transferase activity
GO:0050161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA:oxalate CoA-transferase
GO:0050161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-beta-ketoacyl-CoA transferase activity
GO:0050161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:oxalate CoA-transferase activity
GO:0050161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalate coenzyme A-transferase activity
RHEA:16634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(34) in tRNA + queuine => guanine + queuosine(34) in tRNA
REACT:R-HSA-6811454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate PP2A (Homo sapiens)
RHEA:49676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 = H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)
REACT:R-HSA-174235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdc20 (Homo sapiens)
RHEA:41932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]
REACT:R-DRE-193393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Danio rerio)
RHEA:44153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-phosphate + H2O => myo-inositol + phosphate
REACT:R-HSA-8950063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB2 binds JAK2 (Homo sapiens)
RHEA:31807	skos:prefLabel	"alpha-guaiene synthase"
RHEA:31807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-guaiene synthase"
RHEA:31807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = alpha-guaiene + diphosphate
REACT:R-GGA-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Gallus gallus)
REACT:R-BTA-373734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin interacts with Podocin (Bos taurus)
REACT:R-XTR-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Xenopus tropicalis)
RHEA:66565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine + L-glutaminyl-[protein] => 5-histaminyl-L-glutamyl-[protein] + NH4(+)
RHEA:15109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH
RHEA:15109	skos:prefLabel	"2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase"
RHEA:15109	skos:altLabel	"2-keto-3-deoxy-D-gluconate dehydrogenase"
RHEA:15109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase"
RHEA:25639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + sulfoacetate => H2O + NAD(+) + sulfoacetaldehyde
REACT:R-MMU-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Mus musculus)
REACT:R-MMU-8852716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin, ELANE cleave C5 (Mus musculus)
RHEA:56685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine
RHEA:57670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:68995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3-amino-2,4-dihydroxybenzoate + H2O + NADP(+)
RHEA:46630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,17beta-diol + NADP(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH
RHEA:58013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic tetraadenylate => 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate
RHEA:68041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lanthionine ketimine + 2 H(+) + NADPH => (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)
REACT:R-HSA-9012208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-26A and B bind to the 3'UTR of the KPNA2 mRNA (Homo sapiens)
REACT:R-HSA-9754644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 E pentamer binds TJP1 (Homo sapiens)
RHEA:48921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:53425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + a sphingoid base => an N-acyl-sphingoid base + CoA + H(+)
REACT:R-DRE-8938356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RMB14 binds RUNX2 (Danio rerio)
REACT:R-HSA-981497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Homo sapiens)
RHEA:70192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NAD(+) => 3'-NADP(+) + ADP + H(+)
REACT:R-XTR-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Xenopus tropicalis)
REACT:R-DRE-936802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)
REACT:R-BTA-977348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHGDH tetramer dehydrogenates 3PG (Bos taurus)
GO:0004364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-(hydroxyalkyl)glutathione lyase activity
GO:0004364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RX:glutathione R-transferase activity
GO:0004364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione S-transferase activity
GO:0004364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione S-alkyl transferase activity
GO:0004364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione S-aryltransferase activity
GO:0004364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione S-alkyltransferase activity
GO:0004364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione S-aralkyltransferase activity
GO:0004364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione conjugation reaction
GO:0004364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione transferase activity
REACT:R-XTR-4641350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TOP2A with SUMO2,3 (Xenopus tropicalis)
REACT:R-MMU-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Mus musculus)
REACT:R-SPO-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Schizosaccharomyces pombe)
REACT:R-XTR-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Xenopus tropicalis)
REACT:R-SSC-9707186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 binds ALOX5 inhibitors (Sus scrofa)
REACT:R-CFA-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Canis familiaris)
REACT:R-SSC-164617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of Extended Telomeric Chromosome End (Sus scrofa)
REACT:R-GGA-9645481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIFA oligomerization (Gallus gallus)
REACT:R-SSC-9663511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds GSTA1, FABP1 (Sus scrofa)
REACT:R-SCE-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Saccharomyces cerevisiae)
GO:0004453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	juvenile hormone carboxyesterase activity
GO:0004453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity
GO:0004453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	juvenile hormone analog esterase activity
GO:0004453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juvenile-hormone esterase activity
GO:0004453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	JH-esterase activity
GO:0004453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	JH esterase activity
REACT:R-DDI-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Dictyostelium discoideum)
REACT:R-SSC-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Sus scrofa)
REACT:R-DME-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Drosophila melanogaster)
RHEA:36529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-3-oxodocosenoyl-CoA + CO2 + CoA => (11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA
RHEA:18352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)
REACT:R-HSA-169895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk's SH3 domain engages C3G (Homo sapiens)
REACT:R-BTA-1013020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Bos taurus)
RHEA:51093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-373715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with ROBO1 (Homo sapiens)
REACT:R-RNO-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Rattus norvegicus)
EC:1.13.11.61	skos:altLabel	"(9R)-LOX"
EC:1.13.11.61	skos:prefLabel	"linolenate 9R-lipoxygenase"
EC:1.13.11.61	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linolenate 9R-lipoxygenase"
EC:1.13.11.61	skos:altLabel	"linoleate 9R-dioxygenase"
REACT:R-CEL-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Caenorhabditis elegans)
RHEA:54288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]
REACT:R-CFA-8877902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated AR binds RUNX2 (Canis familiaris)
GO:0016629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity
GO:0016629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-phytodienoate reductase activity
GO:0016629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	12-oxo-phytodienoic acid reductase activity
GO:0016629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxophytodienoate reductase activity
RHEA:46093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:42121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH
RHEA:15194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + H2O => 2'-deoxyguanosine + H(+) + triphosphate
REACT:R-RNO-193679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-secretase cleaves the p75NTR extracellular domain (Rattus norvegicus)
RHEA:61919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + fluconazole(in) + H2O <=> ADP + fluconazole(out) + H(+) + phosphate
RHEA:70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate <=> (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)
REACT:R-DME-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-RNO-5362448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh C-terminal fragments are degraded by the proteasome (Rattus norvegicus)
RHEA:11450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + pregnan-21-al => NAD(+) + pregnan-21-ol
REACT:R-CFA-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Canis familiaris)
RHEA:22582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z)-2-hydroxypenta-2,4-dienoate + H2O => (S)-4-hydroxy-2-oxopentanoate
GO:0043168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anion binding
RHEA:63732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan O-beta-D-glucuronoside
REACT:R-HSA-2029453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of VAV (Homo sapiens)
REACT:R-BTA-8847977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRK phosphorylates PTEN (Bos taurus)
REACT:R-DRE-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Danio rerio)
GO:0052851	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ferric chelate reductase activity
GO:0052851	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	iron chelate reductase activity
GO:0052851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric-chelate reductase (NADPH) activity
GO:0052851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric reductase, NADPH-dependent activity
REACT:R-RNO-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
RHEA:17411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-coclaurine + S-adenosyl-L-methionine
REACT:R-DME-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Drosophila melanogaster)
REACT:R-SPO-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Schizosaccharomyces pombe)
RHEA:15611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+) => ATP + D-ribose 5-phosphate
REACT:R-SCE-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Saccharomyces cerevisiae)
REACT:R-HSA-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Homo sapiens)
REACT:R-MMU-8983003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Mus musculus)
REACT:R-DRE-5635864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH ubiquitinates GLI1 (Danio rerio)
RHEA:35802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + H(+)
REACT:R-DRE-177941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:GAB1 binds to phosphorylated EGFR (Danio rerio)
REACT:R-CFA-8953418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 complex binds E2F6.com-1 core (Canis familiaris)
GO:0102827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosylononitol-raffinose galactosyltransferase activity
REACT:R-SSC-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Sus scrofa)
REACT:R-HSA-5683355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix (Homo sapiens)
REACT:R-DRE-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Danio rerio)
RHEA:33573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + formaldehyde => A + methanol
RHEA:35910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-BTA-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Bos taurus)
GO:0047707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-CoA ligase activity
GO:0047707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotinyl coenzyme A synthetase activity
GO:0047707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotinyl-CoA synthetase activity
GO:0047707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin:CoA ligase (AMP-forming)
GO:0047707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin CoA synthetase activity
RHEA:69574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine + IMP => dIMP + inosine
RHEA:64961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + H2O => dTMP + H(+) + phosphate
REACT:R-RNO-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
REACT:R-DRE-2022405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)
REACT:R-DRE-198440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Danio rerio)
REACT:R-MMU-2512800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1:ligand is endocytosed (Mus musculus)
REACT:R-DRE-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Danio rerio)
REACT:R-SSC-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Sus scrofa)
REACT:R-CFA-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Canis familiaris)
RHEA:14931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADH => NAD(+) + testosterone
REACT:R-MMU-5625424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The retrograde IFT train dissociates (Mus musculus)
REACT:R-BTA-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Bos taurus)
RHEA:29663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + xanthine(in) = H(+)(out) + xanthine(out)
RHEA:37665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:54158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2
RHEA:46344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA
REACT:R-BTA-8950405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Bos taurus)
RHEA:58040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)
REACT:R-BTA-6805507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 binds AVEN (Bos taurus)
REACT:R-HSA-9706356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL mutants don't ubiquitinate FLT3 (Homo sapiens)
REACT:R-CFA-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Canis familiaris)
RHEA:25300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + 2 H(+) + NADPH => acetaldehyde + H2O + NADP(+)
REACT:R-RNO-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Rattus norvegicus)
REACT:R-HSA-9639287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)
REACT:R-RNO-5662613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 exchanges zinc for copper (Rattus norvegicus)
REACT:R-DRE-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Danio rerio)
REACT:R-CEL-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Caenorhabditis elegans)
REACT:R-DRE-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Danio rerio)
REACT:R-MMU-622415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 binds NEMO (Mus musculus)
REACT:R-SPO-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Schizosaccharomyces pombe)
REACT:R-MMU-3222116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L3MBTL1 binds TP53 monomethylated on K382 (Mus musculus)
RHEA:44767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:37109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(7)-methylguanosine + phosphate => H2O + N(7)-methyl-GMP
REACT:R-DDI-5672329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CLIP1 and microtubules (Dictyostelium discoideum)
RHEA:13518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dTMP => ADP + dTDP
REACT:R-RNO-354087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
REACT:R-MMU-4086223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IX binds integrin alpha11beta1 (Mus musculus)
RHEA:29291	skos:prefLabel	"3-oxocholest-4-en-26-oate--CoA ligase"
RHEA:29291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oate + ATP + CoA = (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate
RHEA:29291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxocholest-4-en-26-oate--CoA ligase"
REACT:R-DME-399712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Drosophila melanogaster)
RHEA:52624	skos:prefLabel	"glutamate--[amino group carrier protein] ligase"
RHEA:52624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate--[amino group carrier protein] ligase"
RHEA:52624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate
RHEA:44921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH => (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)
RHEA:11412	skos:altLabel	"2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase"
RHEA:11412	skos:altLabel	"6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase"
RHEA:11412	skos:altLabel	"6-hydroxymethyl-7,8-dihydropterin diphosphokinase"
RHEA:11412	skos:altLabel	"7,8-dihydro-6-hydroxymethylpterin diphosphokinase"
RHEA:11412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase"
RHEA:11412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)
RHEA:11412	skos:altLabel	"7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase"
RHEA:11412	skos:prefLabel	"2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase"
RHEA:47281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-2426569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and IREM2 (Homo sapiens)
REACT:R-CFA-983425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Canis familiaris)
REACT:R-MMU-9018880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Mus musculus)
RHEA:18749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH
REACT:R-MMU-1535903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Mus musculus)
REACT:R-RNO-1678921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length TLR3/7/8/9 binds to UNC93B1 (Rattus norvegicus)
REACT:R-RNO-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Rattus norvegicus)
RHEA:43055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoate + ATP + CoA <=> 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate
REACT:R-BTA-201821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Bos taurus)
RHEA:58492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type ferric enterobactin transporter"
RHEA:58492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Fe(III)-enterobactin(out) + H2O = ADP + Fe(III)-enterobactin(in) + H(+) + phosphate
RHEA:58492	skos:altLabel	"ferric enterobactin ABC transporter"
RHEA:58492	skos:prefLabel	"ABC-type ferric enterobactin transporter"
RHEA:58492	skos:altLabel	"ferric enterobactin transporting ATPase"
RHEA:43501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucuronate + NAD(+) => D-glucaro-1,5-lactone + H(+) + NADH
RHEA:70408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 => (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine
REACT:R-XTR-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Xenopus tropicalis)
RHEA:69047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrobutanedioate <=> fumarate + H(+) + nitrite
GO:0050501	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	seHAS
GO:0050501	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spHAS
GO:0050501	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity
GO:0050501	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	HAS activity
GO:0050501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyaluronan synthase activity
GO:0050501	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1,4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity
RHEA:32287	skos:prefLabel	"3-isopropylmalate dehydratase"
RHEA:32287	skos:altLabel	"alpha-IPM isomerase"
RHEA:32287	skos:altLabel	"(2R,3S)-3-isopropylmalate hydro-lyase"
RHEA:32287	skos:altLabel	"isopropylmalate isomerase"
RHEA:32287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-isopropylmalate dehydratase"
RHEA:32287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
RHEA:32287	skos:altLabel	"3-isopropylmalate hydro-lyase"
REACT:R-BTA-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Bos taurus)
RHEA:61162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + quercitrin + UDP => quercetin + UDP-beta-L-rhamnose
REACT:R-MMU-70920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Mus musculus)
REACT:R-PFA-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Plasmodium falciparum)
RHEA:41720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)
RHEA:50232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:50232	skos:prefLabel	"heme oxygenase (biliverdin-producing, ferredoxin)"
RHEA:50232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heme oxygenase (biliverdin-producing, ferredoxin)"
GO:0044729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hemi-methylated DNA-binding
GO:0044729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded hemi-methylated DNA binding
REACT:R-DRE-140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS1 (Danio rerio)
RHEA:25955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde <=> 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate
RHEA:11292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rifamycin-B oxidase"
RHEA:11292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + rifamycin B = H2O2 + rifamycin O
RHEA:11292	skos:prefLabel	"rifamycin-B oxidase"
REACT:R-MMU-9033959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Mus musculus)
RHEA:10269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate
GO:0016615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate dehydrogenase activity
RHEA:36097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl salicylate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + salicylate
REACT:R-HSA-3000411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates PML with SUMO2 (Homo sapiens)
REACT:R-CFA-419351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF receptor binds platelet activating factor (Canis familiaris)
RHEA:60801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A53 + O2 => CO2 + gibberellin A44 + succinate
REACT:R-XTR-140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Xenopus tropicalis)
RHEA:59319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose + O2 <=> D-cellobiono-1,5-lactone + H2O2
REACT:R-MMU-5671993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT-3 binds DLG4 (Mus musculus)
REACT:R-HSA-8853429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLDA1 binds AURKA (Homo sapiens)
REACT:R-SPO-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Schizosaccharomyces pombe)
RHEA:12049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate + succinyl-CoA => 3-oxoadipyl-CoA + succinate
RHEA:56035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)
REACT:R-BTA-9011595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Bos taurus)
REACT:R-BTA-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Bos taurus)
REACT:R-DME-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Drosophila melanogaster)
RHEA:39642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA <=> (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O
REACT:R-DDI-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)
REACT:R-RNO-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Rattus norvegicus)
RHEA:51580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) = a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
REACT:R-SPO-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Schizosaccharomyces pombe)
RHEA:41163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-amino-sn-glycerol + ATP = 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)
RHEA:36920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA
REACT:R-DRE-927813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
RHEA:56943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate <=> 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate
REACT:R-RNO-6798317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Rattus norvegicus)
REACT:R-MMU-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Mus musculus)
RHEA:70348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + L-tyrosine + NADP(+) => 3-bromo-L-tyrosine + NADPH
REACT:R-XTR-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Xenopus tropicalis)
GO:0004141	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desthiobiotin synthase activity
GO:0004141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dethiobiotin synthase activity
GO:0004141	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)
GO:0004141	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DTB synthetase activity
RHEA:59344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + O2 = D-maltobiono-1,5-lactone + H2O2
REACT:R-CFA-1602399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLB1 (Canis familiaris)
REACT:R-DRE-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Danio rerio)
REACT:R-CEL-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Caenorhabditis elegans)
REACT:R-XTR-4754187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Xenopus tropicalis)
REACT:R-HSA-190413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2c (Homo sapiens)
GO:0047214	skos:prefLabel	"cyanidin 3-O-rutinoside 5-O-glucosyltransferase"
GO:0047214	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity
GO:0047214	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity
GO:0047214	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity
GO:0047214	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity
GO:0047214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity
GO:0047214	skos:altLabel	"uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase"
GO:0047214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanidin 3-O-rutinoside 5-O-glucosyltransferase"
GO:0047214	skos:altLabel	"cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase"
RHEA:39236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytriacontanoyl-CoA => (2E)-triacontenoyl-CoA + H2O
RHEA:21595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) <=> H(+) + L-2-aminopentanoate + NADH + pyruvate
REACT:R-MMU-192042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Mus musculus)
RHEA:47097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate
EC:2.4.1.186	skos:altLabel	"glycogenin"
EC:2.4.1.186	skos:prefLabel	"glycogenin glucosyltransferase"
EC:2.4.1.186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycogenin glucosyltransferase"
EC:2.4.1.186	skos:altLabel	"priming glucosyltransferase"
REACT:R-BTA-6800490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates PIDD1 (Bos taurus)
REACT:R-GGA-5626681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of transition zone proteins (Gallus gallus)
REACT:R-DME-391942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP receptor can bind prostacyclin (Drosophila melanogaster)
RHEA:42443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NAD(+) <=> H(+) + iminosuccinate + NADH
RHEA:42614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinol + n H(+)(out) + NADP(+) => a plastoquinone + (n+1) H(+)(in) + NADPH
RHEA:57657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1b => CMP + ganglioside GT1balpha + H(+)
RHEA:37503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:36313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 H(+) + NADH => 3,4-dihydroxybenzaldehyde + H2O + NAD(+)
REACT:R-SSC-109449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Sus scrofa)
REACT:R-CFA-71050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of the FASL:FAS receptor complex (Canis familiaris)
REACT:R-SCE-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)
GO:0140382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptamine 4-monooxygenase activity
REACT:R-MMU-9014812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBOs bind keratan sulfate (Mus musculus)
RHEA:10369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
REACT:R-MMU-2473184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follistatin (FST) binds Activin (Mus musculus)
REACT:R-XTR-8938356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RMB14 binds RUNX2 (Xenopus tropicalis)
RHEA:17908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH
REACT:R-SSC-9714924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to soluble TNF trimer (Sus scrofa)
REACT:R-CFA-445699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Canis familiaris)
REACT:R-MMU-70355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALK1 phosphorylates Gal to Gal1P (Mus musculus)
RHEA:15345	skos:altLabel	"kyotorphin-synthesizing enzyme"
RHEA:15345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginine + L-tyrosine = AMP + diphosphate + H(+) + L-tyrosyl-L-arginine
RHEA:15345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine--arginine ligase"
RHEA:15345	skos:altLabel	"tyrosyl-arginine synthase"
RHEA:15345	skos:altLabel	"kyotorphin synthase"
RHEA:15345	skos:prefLabel	"tyrosine--arginine ligase"
RHEA:60142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanoyl-CoA + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-CoA
REACT:R-CFA-4420153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds PLCG1 (Canis familiaris)
RHEA:45105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-demethylmitomycin A + S-adenosyl-L-methionine => mitomycin A + S-adenosyl-L-homocysteine
REACT:R-CEL-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Caenorhabditis elegans)
REACT:R-XTR-5649734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates NEIL1,NEIL2-generated single strand break (Xenopus tropicalis)
REACT:R-DME-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Drosophila melanogaster)
REACT:R-MMU-2187405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 binds phosphorylated SMAD2/3 (Mus musculus)
REACT:R-RNO-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
RHEA:39524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O
RHEA:37345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + phosphate => adenosine 2'-phosphate + H2O
REACT:R-GGA-2064406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Gallus gallus)
REACT:R-XTR-5695964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD14B hydrolyses PNPB (Xenopus tropicalis)
RHEA:57930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine
REACT:R-BTA-71286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Bos taurus)
GO:0080018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin 5-O-glucosyltransferase activity
REACT:R-MMU-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Mus musculus)
RHEA:30858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammarenediol-II <=> (S)-2,3-epoxysqualene + H2O
REACT:R-CEL-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Caenorhabditis elegans)
RHEA:60269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:38080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-CEL-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Caenorhabditis elegans)
REACT:R-GGA-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Gallus gallus)
REACT:R-SSC-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Sus scrofa)
REACT:R-SSC-192051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7A1 7-hydroxylates CHOL (Sus scrofa)
REACT:R-DRE-349603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Danio rerio)
REACT:R-BTA-5357479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AXL binds PI3K (Bos taurus)
RHEA:38471	skos:prefLabel	"L-histidine N(alpha)-methyltransferase"
RHEA:38471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-histidine N(alpha)-methyltransferase"
RHEA:38471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine
RHEA:38471	skos:altLabel	"dimethylhistidine N-methyltransferase"
RHEA:14454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(phosphooxy)-L-threonine + NAD(+) => (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH
REACT:R-RNO-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Rattus norvegicus)
GO:0102580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose = an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP
GO:0102580	skos:prefLabel	"anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase"
GO:0102580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase"
GO:0102580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity
REACT:R-MMU-9025999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Mus musculus)
GO:0046812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	host cell surface binding
RHEA:66182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + bilirubin-glucuronoside(out) + H(+) + phosphate => ATP + bilirubin-glucuronoside(in) + H2O
REACT:R-GGA-159773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein S to protein S (Gallus gallus)
RHEA:57040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-apiose = D-apiofuranose
RHEA:50736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + 2 H(+) + hydrogen sulfide + sulfite = a quinol + thiosulfate
RHEA:50736	skos:prefLabel	"thiosulfate reductase (quinone)"
RHEA:50736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiosulfate reductase (quinone)"
RHEA:15002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-sorbose + NADP(+) => 5-dehydro-D-fructose + H(+) + NADPH
EC:1.5.3.13	skos:altLabel	"PAO"
EC:1.5.3.13	skos:prefLabel	"N(1)-acetylpolyamine oxidase"
EC:1.5.3.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(1)-acetylpolyamine oxidase"
EC:1.5.3.13	skos:altLabel	"polyamine oxidase"
RHEA:72182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauro-beta-muricholate(out) <=> 2 Na(+)(in) + tauro-beta-muricholate(in)
REACT:R-GGA-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Gallus gallus)
RHEA:32563	skos:prefLabel	"alpha-terpinene synthase"
RHEA:32563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-terpinene synthase"
RHEA:32563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = alpha-terpinene + diphosphate
RHEA:42296	skos:prefLabel	"1-acyl-sn-glycerol-3-phosphate acyltransferase"
RHEA:42296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]
RHEA:42296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-acyl-sn-glycerol-3-phosphate acyltransferase"
REACT:R-BTA-9684068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD binds cardiac glycosides (Bos taurus)
REACT:R-BTA-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Bos taurus)
RHEA:39095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydecanedioyl-CoA + NAD(+) = 3-oxodecanedioyl-CoA + H(+) + NADH
REACT:R-SSC-937311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP12A:ATP4B exchanges K+ for H+ (Sus scrofa)
REACT:R-SCE-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)
GO:0004312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid synthase activity
GO:0004312	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
GO:0004312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acid synthase activity
RHEA:15779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-guanidino-1-deoxy-scyllo-inositol + phosphate => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O
RHEA:41580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase"
RHEA:41580	skos:altLabel	"dihydrophenazine-1-carboxylate dimethylallyltransferase"
RHEA:41580	skos:prefLabel	"5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase"
RHEA:41580	skos:altLabel	"5,10-dihydrophenazine 1-carboxylate dimethylallyltransferase"
RHEA:41580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate = 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate
RHEA:41648	skos:prefLabel	"gamma-glutamylanilide synthase"
RHEA:41648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aniline + ATP + L-glutamate = ADP + N(5)-phenyl-L-glutamine + phosphate
RHEA:41648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-glutamylanilide synthase"
RHEA:71784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate(out) + H(+)(out) => 3-methyl-2-oxobutanoate(in) + H(+)(in)
RHEA:31941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:66148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + acetyl-CoA = CoA + H(+) + N-(2-phenylethyl)acetamide
RHEA:61398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein]
REACT:R-BTA-174427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Bos taurus)
REACT:R-HSA-6788392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
RHEA:12913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate + ATP + H(+) = (R)-lipoyl-5'-AMP + diphosphate
RHEA:17447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2 + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-2213192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemidesmosome formation (Homo sapiens)
REACT:R-RNO-1433423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP-RO interacts with p-c-Kit complex (Rattus norvegicus)
RHEA:22444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferol + NADP(+) = (E)-coniferaldehyde + H(+) + NADPH
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-CoA transferase activity
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinyl-CoA:3-ketoacid-CoA transferase
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA:3-oxo-acid CoA-transferase activity
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetate succinyl-CoA transferase activity
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoacid coenzyme A-transferase activity
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacid CoA-transferase activity
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoacid CoA dehydrogenase activity
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetyl coenzyme A-succinic thiophorase activity
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA 3-ketoacid-CoA transferase activity
GO:0008260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA transferase activity
REACT:R-CFA-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Canis familiaris)
REACT:R-DDI-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Dictyostelium discoideum)
REACT:R-PFA-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Plasmodium falciparum)
REACT:R-HSA-2130640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of clathrin coated vesicle by Ii (Homo sapiens)
REACT:R-HSA-9026912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT hydrolyses PCTR1 to PCTR2 (Homo sapiens)
RHEA:66102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-kynurenine
RHEA:18720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine
REACT:R-HSA-2691214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 HD domain mutants bind JAG2 (Homo sapiens)
REACT:R-DRE-8950410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B:IL12B translocates from ER lumen to the extracellular region (Danio rerio)
REACT:R-GGA-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Gallus gallus)
REACT:R-DRE-74059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Danio rerio)
RHEA:27388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + maleamate <=> maleate + NH4(+)
REACT:R-MMU-1250380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Mus musculus)
REACT:R-HSA-751027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)
RHEA:60474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)
REACT:R-DRE-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Danio rerio)
REACT:R-BTA-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Bos taurus)
REACT:R-DME-77319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Drosophila melanogaster)
RHEA:33895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose = H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose
RHEA:33895	skos:prefLabel	"decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase"
RHEA:33895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase"
RHEA:33895	skos:altLabel	"decaprenylphospho-beta-D-ribofuranose 2'-epimerase"
RHEA:16136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine + O2 <=> 3-aminopropanal + H2O2 + N(1)-acetylspermidine
RHEA:25975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(8)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine
REACT:R-PFA-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Plasmodium falciparum)
RHEA:58571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine + acetyl-CoA <=> CoA + O-acetyl-15alpha-stemmadenine
REACT:R-HSA-451347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JNK by DSCAM (Homo sapiens)
GO:0033190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solanapyrone synthase activity
REACT:R-SSC-9008822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1D dephosphorylates RUNX2 (Sus scrofa)
REACT:R-HSA-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Homo sapiens)
REACT:R-MMU-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Mus musculus)
REACT:R-DRE-6805022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 binds the heterodimer of MDM2 and MDM4 (Danio rerio)
REACT:R-GGA-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Gallus gallus)
RHEA:64956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP + 2 H2O = dTMP + 2 H(+) + 2 phosphate
RHEA:15287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate => AMP + dimethylallyl diphosphate
REACT:R-SPO-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Schizosaccharomyces pombe)
RHEA:55073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + H(+) => CO2 + propanal
RHEA:57148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
RHEA:17493	skos:prefLabel	"glycerol dehydrogenase (acceptor)"
RHEA:17493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + glycerol = AH2 + dihydroxyacetone
RHEA:17493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol dehydrogenase (acceptor)"
RHEA:64671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate
REACT:R-MMU-9034042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Mus musculus)
RHEA:25096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dCDP => ATP + dCMP
GO:0090582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RHEA:42009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-pregnan-20beta-ol-3-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH
RHEA:33974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5''-phosphoribostamycin + H2O <=> phosphate + ribostamycin
RHEA:29445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanine(out) => H(+)(in) + L-alanine(in)
REACT:R-BTA-4793925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S303,307-HSF1 binds YWHAE (14-3-3) (Bos taurus)
REACT:R-BTA-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Bos taurus)
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose-sodium symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+ (Li+)/melibiose symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose/sodium symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose:sodium symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-melibiose symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-melibiose symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose/Na+ symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+:melibiose symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiomethylgalactoside permease II
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	melibiose carrier protein
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose:Na+ symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/melibiose symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MelB
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	melibiose permease
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:melibiose symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/melibiose symporter activity
GO:0043887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose-Na+ symporter activity
GO:0102757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH phosphatase activity
REACT:R-CFA-202541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
REACT:R-CEL-8938217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SWI/SNF complex (Caenorhabditis elegans)
REACT:R-BTA-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Bos taurus)
RHEA:48630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in rRNA + S-adenosyl-L-methionine
REACT:R-DME-111804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
REACT:R-CEL-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Caenorhabditis elegans)
RHEA:63746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP + zolarsartan-1-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan
GO:0070279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B6 binding
REACT:R-XTR-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Xenopus tropicalis)
RHEA:70700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) => H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)
REACT:R-CFA-5672843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1S1 (PRAS40) binds mTORC1 (Canis familiaris)
REACT:R-XTR-5362525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1,C1 4-hydroxylate atRA (Xenopus tropicalis)
REACT:R-MMU-8857583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by PTK6 (Mus musculus)
REACT:R-XTR-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Xenopus tropicalis)
RHEA:50964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(cytosine(8)) deaminase"
RHEA:50964	skos:prefLabel	"tRNA(cytosine(8)) deaminase"
RHEA:50964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(8) in tRNA + H(+) + H2O = NH4(+) + uridine(8) in tRNA
RHEA:50282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2
RHEA:23950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + succinate semialdehyde => 4-hydroxybutanoate + NAD(+)
RHEA:31539	skos:prefLabel	"naringenin 7-O-methyltransferase"
RHEA:31539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"naringenin 7-O-methyltransferase"
RHEA:31539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + S-adenosyl-L-methionine = (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine
RHEA:32518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)
RHEA:59779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + O2 <=> D-arabinose + H2O2
RHEA:21994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-acetyl-L-lysyl-[histone] => acetyl-CoA + L-lysyl-[histone]
REACT:R-RNO-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Rattus norvegicus)
REACT:R-BTA-71050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of the FASL:FAS receptor complex (Bos taurus)
REACT:R-GGA-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Gallus gallus)
RHEA:38404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)
RHEA:13804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + hydrogen sulfide + 3 NADP(+) <=> 4 H(+) + 3 NADPH + sulfite
REACT:R-XTR-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Xenopus tropicalis)
GO:0047227	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity
GO:0047227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indolylacetyl-myo-inositol galactosyltransferase activity
GO:0047227	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity
GO:0047227	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity
GO:0047227	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indol-3-ylacetyl-myo-inositol galactoside synthase activity
RHEA:66643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + koraiol
REACT:R-RNO-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Rattus norvegicus)
REACT:R-MMU-2029272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of PLCG from FCGR (Mus musculus)
REACT:R-RNO-9025957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Rattus norvegicus)
REACT:R-SSC-5423678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 hydroxylates AFB1 to AFM1 (Sus scrofa)
RHEA:46965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate
RHEA:17396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-maleylpyruvate <=> 3-fumarylpyruvate
RHEA:19700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate
REACT:R-BTA-177157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Bos taurus)
RHEA:48568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chlorocatechol + O2 = (2E,4Z)-2-chloromuconate + 2 H(+)
REACT:R-DME-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Drosophila melanogaster)
REACT:R-GGA-5654677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR2 (Gallus gallus)
RHEA:65728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + hexyl sulfate + O2 = CO2 + H(+) + hexanal + succinate + sulfate
GO:0050294	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity
GO:0050294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Homo sapiens)
GO:0050294	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid alcohol sulfotransferase
GO:0050294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid sulfotransferase activity
GO:0050294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid sulphotransferase activity
REACT:R-CEL-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Caenorhabditis elegans)
REACT:R-RNO-6813740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDE1 hydrolyzes GroPIns (Rattus norvegicus)
REACT:R-CFA-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Canis familiaris)
REACT:R-RNO-71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Rattus norvegicus)
RHEA:60426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + valerianol => (2E,6E)-farnesyl diphosphate + H2O
RHEA:36402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3beta-ol + NADP(+) <=> H(+) + NADPH + zymosterol
REACT:R-SCE-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Saccharomyces cerevisiae)
RHEA:15684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) <=> (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH
REACT:R-HSA-2029465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
RHEA:34443	skos:prefLabel	"dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase"
RHEA:34443	skos:altLabel	"TDP-fucosamine acetyltransferase"
RHEA:34443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)
RHEA:34443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase"
REACT:R-XTR-9638064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Xenopus tropicalis)
RHEA:11696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-demethylstaurosporine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + staurosporine
RHEA:11696	skos:prefLabel	"3'-demethylstaurosporine O-methyltransferase"
RHEA:11696	skos:altLabel	"3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase"
RHEA:11696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3'-demethylstaurosporine O-methyltransferase"
RHEA:11696	skos:altLabel	"staurosporine synthase"
RHEA:27322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)
RHEA:65304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + verruculide A = chrodrimanin T + CO2 + succinate
RHEA:41158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+)
REACT:R-BTA-6800198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Bos taurus)
REACT:R-CEL-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Caenorhabditis elegans)
RHEA:47702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + iso-precytochalasin + NADP(+) => H(+) + ketocytochalasin + NADPH + O2
REACT:R-HSA-8952371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds RUNX3 (Homo sapiens)
REACT:R-SSC-5668454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Sus scrofa)
REACT:R-RNO-389941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)
RHEA:65883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-5alpha-androstan-3,17-dione + A <=> 5alpha-androstan-1,3,17-trione + AH2
REACT:R-CEL-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Caenorhabditis elegans)
GO:0052881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxyphenylacetate hydroxylase (FAD) activity
GO:0052881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate 3-monooxygenase activity
GO:0052881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxyphenylacetate 3-hydroxylase (FAD) activity
GO:0052881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate,FADH:oxygen oxidoreductase (3-hydroxylating) activity
GO:0052881	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	p-hydroxyphenylacetate 3-hydroxylase activity
GO:0052881	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	4-hydroxyphenylacetic acid-3-hydroxylase activity
GO:0052881	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	p-hydroxyphenylacetate hydroxylase activity
GO:0052881	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	4 HPA 3-hydroxylase activity
REACT:R-DME-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Drosophila melanogaster)
REACT:R-HSA-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Homo sapiens)
REACT:R-DME-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
REACT:R-HSA-9020271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Homo sapiens)
REACT:R-SCE-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Saccharomyces cerevisiae)
RHEA:39154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-CoA + NADP(+)
RHEA:70623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-209125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Homo sapiens)
RHEA:65460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hexan-1-ol = CoA + hexyl acetate
RHEA:67858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]
REACT:R-DRE-2161620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by PTGDS (Danio rerio)
REACT:R-MMU-8982640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Mus musculus)
RHEA:27431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + H2O
REACT:R-DRE-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Danio rerio)
RHEA:71701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-phenylalanyl-L-leucine(in) => H(+)(out) + L-phenylalanyl-L-leucine(out)
REACT:R-RNO-6786048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Rattus norvegicus)
RHEA:69489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecan-1-ol => H2O2 + tetradecanal
RHEA:64315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride + 2 FADH2 + 2 O2 + sulochrin <=> dihydrogeodin + 2 FAD + H(+) + 4 H2O
RHEA:29506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + patchoulol
REACT:R-CFA-6799495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYCTK phosphorylates DGA to 3PDGA (Canis familiaris)
RHEA:44721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycerol + H(+) + phosphocholine
REACT:R-GGA-9714483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the ER membrane (Gallus gallus)
REACT:R-PFA-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Plasmodium falciparum)
REACT:R-DRE-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Danio rerio)
REACT:R-BTA-2213235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of nonameric complex in the endocytic pathway (Bos taurus)
REACT:R-GGA-9709360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 reduces MetHb (Gallus gallus)
REACT:R-RNO-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)
RHEA:70088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol + o-quinone methide => hydroxyclavatol methyl ether
RHEA:30976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 5 A => 5 AH2 + all-trans-3,4-didehydrolycopene
REACT:R-CFA-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Canis familiaris)
REACT:R-MMU-1614461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetramerization of procollagen VI (Mus musculus)
REACT:R-RNO-389622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)
RHEA:18082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + pentalenene
EC:2.8.3.13	skos:prefLabel	"succinate--hydroxymethylglutarate CoA-transferase"
EC:2.8.3.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinate--hydroxymethylglutarate CoA-transferase"
REACT:R-MMU-2152276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of transmembrane collagens (Mus musculus)
REACT:R-DME-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Drosophila melanogaster)
REACT:R-MMU-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Mus musculus)
REACT:R-XTR-8853793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET complexes bind GRB2 (Xenopus tropicalis)
RHEA:15695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2
RHEA:51132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase
REACT:R-XTR-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Xenopus tropicalis)
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in canonical Wnt signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in canonical Wnt-activated signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in frizzled-1 receptor signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in canonical Wnt receptor signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in canonical Wnt signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wnt co-receptor, canonical pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in canonical Wnt receptor signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wnt co-receptor activity, canonical signaling
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	coreceptor activity involved in frizzled-1 receptor signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in canonical Wnt signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt receptor signalling pathway through beta-catenin
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in canonical Wnt receptor signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in canonical Wnt-activated signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt receptor signaling pathway via beta-catenin
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in canonical Wnt-activated signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in frizzled-1 receptor signaling pathway
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt receptor signaling pathway through beta-catenin
GO:1904928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin
REACT:R-HSA-5666169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
RHEA:49793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + glycine => CoA + H(+) + N-eicosanoylglycinate
REACT:R-XTR-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Xenopus tropicalis)
RHEA:58545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-tetradecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine
RHEA:37687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-PFA-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Plasmodium falciparum)
REACT:R-GGA-8874206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L3 (Gallus gallus)
GO:0043714	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	citramalate synthase
GO:0043714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-citramalate synthase activity
REACT:R-DRE-4551768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO2,3 (Danio rerio)
RHEA:59084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)
RHEA:54978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanoate + CoA + H(+) => (3S)-hydroxytetradecanoyl-CoA + H2O
REACT:R-DRE-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Danio rerio)
REACT:R-HSA-8949301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RORC gene expression is stimulated by RUNX3:CBFB (Homo sapiens)
REACT:R-RNO-6803523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Rattus norvegicus)
RHEA:32485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + methanol + pyropheophorbide a => H(+) + H2O + pheophorbide a
REACT:R-MMU-158145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Mus musculus)
REACT:R-SCE-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Saccharomyces cerevisiae)
REACT:R-RNO-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Rattus norvegicus)
REACT:R-MMU-977317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Mus musculus)
RHEA:67797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA
RHEA:66835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + preasperterpenoid A
RHEA:68313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O => 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate
RHEA:62705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyldehydrophenylalanine + H2O => 2,3-didehydrophenylalanine + glycine
RHEA:71696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + L-alanyl-L-aspartate(out) => 2 H(+)(in) + L-alanyl-L-aspartate(in)
GO:0051738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthophyll binding
RHEA:47459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) <=> 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH
REACT:R-SCE-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Saccharomyces cerevisiae)
RHEA:20609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-D-pentonate aldolase"
RHEA:20609	skos:altLabel	"2-keto-3-deoxy-D-pentonate aldolase"
RHEA:20609	skos:prefLabel	"2-dehydro-3-deoxy-D-pentonate aldolase"
RHEA:20609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate
REACT:R-BTA-8952371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds RUNX3 (Bos taurus)
REACT:R-MMU-6810474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Mus musculus)
RHEA:58851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-hydroxygeranial + H(+) + NADH
REACT:R-CFA-8865667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPA hydrolyses sterol esters to sterols and fatty acids (Canis familiaris)
REACT:R-DME-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Drosophila melanogaster)
REACT:R-SSC-9007283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 and PRC1.6 associate with E2F6.com-1 (Sus scrofa)
REACT:R-CFA-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)
REACT:R-DRE-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Danio rerio)
REACT:R-DME-391941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLT receptors can bind LTB4 (Drosophila melanogaster)
REACT:R-XTR-9647977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT methylates S-Farn RAS proteins (Xenopus tropicalis)
REACT:R-CFA-196402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Canis familiaris)
RHEA:28277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-S-adenosyl-L-methionine <=> (R)-S-adenosyl-L-methionine
RHEA:33739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+)
RHEA:22585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + heme b => Fe(2+) + protoporphyrin IX
RHEA:60459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UTP <=> 3',3'-cUAMP + 2 diphosphate
REACT:R-SCE-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Saccharomyces cerevisiae)
REACT:R-DME-1250357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds P-ERBB4 isoform dimers (Drosophila melanogaster)
REACT:R-HSA-5657665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALKBH2 binds alkylated dsDNA containing 3-meC (Homo sapiens)
GO:0043819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobF
GO:0043819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)
GO:0043819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6A synthase (deacetylating) activity
GO:0043819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	precorrin-6X synthase (deacetylating) activity
REACT:R-XTR-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Xenopus tropicalis)
RHEA:47116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoate + glycine = H2O + N-eicosanoylglycinate
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Lewis blood group alpha-(1->3/4)-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Lewis(Le) blood group gene-dependent alpha-(1,3/4)-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-4-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	blood group Lewis alpha-4-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Lewis alpha-(1->3/4)-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Lewis FT activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Lewis blood group alpha-(1,3/4)-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha(1,4)-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(Lea)-dependent (alpha-3/4)-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	galactoside 3(4)-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	FucT-II activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Lewis alpha-(1,3/4)-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-(1->4)-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-acetylglucosaminylsaccharide fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-(1,3/1,4) fucosyltransferase III activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	blood-group substance Lea-dependent fucosyltransferase
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fuca(1,3)-glycosidic linkage formation
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-(1,4)-L-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity
GO:0017060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	blood-group substance Le(a)-dependent fucosyltransferase activity
REACT:R-DRE-427528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Danio rerio)
RHEA:54876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3S)-3-isopropenyl-6-oxoheptanoate + H(+)
RHEA:47353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hexanoate ester + H2O => an aliphatic alcohol + H(+) + hexanoate
RHEA:23836	skos:prefLabel	"D-methionine--pyruvate transaminase"
RHEA:23836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methionine + pyruvate = 4-methylsulfanyl-2-oxobutanoate + L-alanine
RHEA:23836	skos:altLabel	"D-methionine aminotransferase"
RHEA:23836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-methionine--pyruvate transaminase"
RHEA:23836	skos:altLabel	"D-methionine--pyruvate aminotransferase"
RHEA:37518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:55542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate => 40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin]
RHEA:60695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-enal + H2O + NADP(+) <=> (E)-non-2-enoate + 2 H(+) + NADPH
REACT:R-SSC-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Sus scrofa)
REACT:R-HSA-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Homo sapiens)
REACT:R-MMU-6786072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3,p-Y641-STAT6 dissociate (Mus musculus)
REACT:R-DME-9634584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Drosophila melanogaster)
REACT:R-XTR-517536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Xenopus tropicalis)
REACT:R-BTA-9020275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DHA to 17(S)-Hp-DHA (Bos taurus)
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-8-phosphooctulonate synthase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-phosphooctonate aldolase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-keto-3-deoxyoctonate aldolase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxyoctulosonic 8-phosphate synthetase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KDO-8-P synthase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KDO-8-phosphate synthetase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KDOP synthase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-8-phosphooctonic synthetase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxyphosphooctonate aldolase activity
GO:0008676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-manno-octulosonate-8-phosphate synthase activity
RHEA:23555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropane-1,2-diol + NAD(+) <=> 2-hydroxy-2-methylpropanal + H(+) + NADH
RHEA:64311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminobutanoate + pyruvate <=> acetoacetate + L-alanine
REACT:R-BTA-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Bos taurus)
RHEA:40475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+)
RHEA:72156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
EC:7.1.2.-	skos:prefLabel	"Hydron translocation linked to the hydrolysis of a nucleoside triphosphate"
EC:7.1.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hydron translocation linked to the hydrolysis of a nucleoside triphosphate"
REACT:R-DME-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Drosophila melanogaster)
GO:0050056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalool 8-monooxygenase activity
GO:0050056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating)
REACT:R-BTA-750993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (q) reassociates with G beta:gamma (Bos taurus)
REACT:R-MMU-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Mus musculus)
REACT:R-XTR-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Xenopus tropicalis)
RHEA:61065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP
GO:0008569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	minus-end-directed microtubule motor activity
GO:0008569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent minus-end-directed microtubule motor activity
GO:0008569	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	kinesin ATP phosphohydrolase (minus-end-directed)
GO:0008569	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dynein ATPase
GO:0008569	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	minus-end-directed kinesin ATPase activity
GO:0008569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule motor activity, minus-end-directed
GO:0008569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	minus-end-directed ATP-dependent microtubule motor activity
GO:0008569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent microtubule motor activity, minus-end-directed
REACT:R-SPO-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-HSA-6785409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) (Homo sapiens)
REACT:R-MMU-266050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to LTC4 by LTC4S (Mus musculus)
RHEA:21162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + CoA => acetyl-CoA + ADP + oxaloacetate + phosphate
RHEA:45130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
GO:0033436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine tRNA
GO:0033436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUG codon-amino acid adaptor activity
GO:0033436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	initiator methionine tRNA
GO:0033436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG codon-amino acid adaptor activity
RHEA:48798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase]
RHEA:47211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + ubiquinone-8 => dihydroxyacetone phosphate + ubiquinol-8
REACT:R-DDI-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Dictyostelium discoideum)
REACT:R-BTA-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Bos taurus)
REACT:R-SPO-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Schizosaccharomyces pombe)
REACT:R-PFA-8865774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLLs polyglutamylate tubulin (Plasmodium falciparum)
REACT:R-BTA-420265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind IAPP(34-70) (Bos taurus)
REACT:R-DME-69562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Drosophila melanogaster)
REACT:R-DRE-5218847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 binds NCK (Danio rerio)
REACT:R-HSA-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Homo sapiens)
REACT:R-DDI-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Dictyostelium discoideum)
RHEA:51888	skos:prefLabel	"tetrachlorobenzoquinone reductase"
RHEA:51888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrachlorobenzoquinone reductase"
RHEA:51888	skos:altLabel	"TCBQ reductase"
RHEA:51888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH
RHEA:67365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-threonyl-L-serine => L-serine + L-threonine
REACT:R-SSC-2730876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IKK-beta by TAK1 (Sus scrofa)
RHEA:20283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+) => (Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate
RHEA:23135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite
REACT:R-GGA-879930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 is recruited by JAK2 (Gallus gallus)
REACT:R-MMU-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Mus musculus)
RHEA:51692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O
EC:3.4.23.47	skos:prefLabel	"HIV-2 retropepsin"
EC:3.4.23.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"HIV-2 retropepsin"
RHEA:48812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
RHEA:67834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2
RHEA:46855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-HSA-449855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimerizes (Homo sapiens)
RHEA:58328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH
REACT:R-CFA-5696465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP45 deubiquitinates ERCC1 (Canis familiaris)
REACT:R-DRE-9005995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the SIN3A co-repressor complex (Danio rerio)
REACT:R-CEL-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Caenorhabditis elegans)
RHEA:23974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + CO2 + Na(+)(out) => (2E)-glutaconyl-CoA + H(+) + Na(+)(in)
RHEA:31033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucopyranosyl cis-(+)-abscisate + UDP => 2-cis-(+)-abscisate + UDP-alpha-D-glucose
REACT:R-BTA-8951499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides on to class I MHC (Bos taurus)
REACT:R-CFA-8950778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dimerizes (Canis familiaris)
RHEA:54852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptan-4-one + NADPH + O2 = H2O + NADP(+) + propyl butanoate
REACT:R-CFA-351210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Canis familiaris)
REACT:R-BTA-9018859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Bos taurus)
REACT:R-DME-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Drosophila melanogaster)
RHEA:61090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + CO2 + succinate => (S)-eriodictyol + 2-oxoglutarate + O2
REACT:R-DME-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Drosophila melanogaster)
REACT:R-XTR-265645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Influx through Voltage-gated Calcium Channels (Xenopus tropicalis)
RHEA:64859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + phomopsene
REACT:R-XTR-5228521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Xenopus tropicalis)
RHEA:63238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-adenylylstreptomycin + diphosphate => ATP + streptomycin
RHEA:26084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (Z)-gamma-bisabolene + diphosphate
REACT:R-DRE-4754181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me2K5-histone H3 (Danio rerio)
REACT:R-SSC-139899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of BAD protein by 14-3-3 (Sus scrofa)
REACT:R-XTR-9749494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBIP binds IKBKB and CHUK (Xenopus tropicalis)
RHEA:23010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + H2O
RHEA:22289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose
REACT:R-MMU-201631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 3 (Mus musculus)
REACT:R-GGA-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Gallus gallus)
GO:0001000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacterial-type RNA polymerase core enzyme binding
GO:0001000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eubacterial-type RNA polymerase core enzyme binding
REACT:R-XTR-5668718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)
REACT:R-RNO-420127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGRP receptor can bind calcitonin gene-related peptides (Rattus norvegicus)
REACT:R-RNO-9029680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-7 translocates to the nucleus (Rattus norvegicus)
REACT:R-HSA-5389839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)
REACT:R-XTR-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Xenopus tropicalis)
REACT:R-HSA-8878056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds EP300 (Homo sapiens)
RHEA:23524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol O-cinnamoyltransferase"
RHEA:23524	skos:prefLabel	"alcohol O-cinnamoyltransferase"
RHEA:23524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol = an alkyl cinnamate + beta-D-glucose
RHEA:25118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)
REACT:R-SSC-114307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SMAC (DIABLO) from mitochondria (Sus scrofa)
RHEA:33023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH
REACT:R-HSA-9036021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)6 (PP-Dol)1 by ALG9 (Homo sapiens)
REACT:R-SSC-983703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-SYK phosphorylates BLNK (SLP65) (Sus scrofa)
REACT:R-MMU-9706304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRAP2 (Mus musculus)
REACT:R-BTA-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Bos taurus)
REACT:R-BTA-8964274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12) binds BTK (Bos taurus)
REACT:R-MMU-9629492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves spiroiminodihydantoin (Mus musculus)
REACT:R-RNO-4085087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Rattus norvegicus)
REACT:R-DME-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Drosophila melanogaster)
RHEA:17242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-amino acid ester + H2O => an alcohol + an alpha-amino acid + H(+)
RHEA:62714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + stemphyloxin I => betaenone C + H(+) + NADPH + O2
RHEA:57135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate + O2 + tyramine <=> (R)-octopamine + H2O + L-dehydroascorbate
REACT:R-SSC-73931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Sus scrofa)
RHEA:10449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a flavanone + O2 => a flavone + CO2 + H2O + succinate
RHEA:67143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 <=> H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]
RHEA:11143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate <=> D-mannose 6-phosphate
RHEA:54274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2
REACT:R-HSA-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Homo sapiens)
REACT:R-CFA-6806613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin tetramers bind to form unit length filaments (Canis familiaris)
REACT:R-RNO-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Rattus norvegicus)
REACT:R-HSA-6814670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Homo sapiens)
RHEA:61807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-alanine <=> diphosphate + L-alanyl-5'-AMP
REACT:R-GGA-2132094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C8 binds to C5b:C6:C7 complement complex (Gallus gallus)
RHEA:51423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S,3S)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH
REACT:R-RNO-71588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Rattus norvegicus)
REACT:R-HSA-5490269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFXBO-C, AFNBO-C translocate from extracellular region to cytosol (Homo sapiens)
REACT:R-DRE-1237059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ dehydrates HCO3- to CO2 (Danio rerio)
REACT:R-DME-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Drosophila melanogaster)
RHEA:19799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4-bisphosphate + phosphate => 1D-myo-inositol 1,4,5-trisphosphate + H2O
RHEA:63101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ilicicolin C + NADPH + O2 => ascochlorin + 2 H2O + NADP(+)
REACT:R-DRE-9007283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 and PRC1.6 associate with E2F6.com-1 (Danio rerio)
RHEA:47235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-BTA-8944218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VIII (Bos taurus)
REACT:R-DME-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Drosophila melanogaster)
RHEA:33782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-kestotriose + sucrose <=> 6,6-kestotetraose + beta-D-glucose
REACT:R-BTA-1980233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Bos taurus)
RHEA:20483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate => 3'-phosphoadenylyl sulfate + coelenterazine h
REACT:R-HSA-1433454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GAB2 by SFKs (Homo sapiens)
REACT:R-BTA-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Bos taurus)
RHEA:47527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
RHEA:62160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate
REACT:R-HSA-4420143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SH2D2A (Homo sapiens)
RHEA:67920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)
REACT:R-SSC-9006844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21:IL21R:JAK1 binds IL2RG:JAK3 (Sus scrofa)
REACT:R-CFA-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Canis familiaris)
REACT:R-HSA-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
REACT:R-CFA-561072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal uptake of organic cations (Canis familiaris)
REACT:R-PFA-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Plasmodium falciparum)
REACT:R-HSA-193656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with RIP2 (Homo sapiens)
REACT:R-HSA-5358343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT palmitoylates Hh N-terminal fragment (Homo sapiens)
RHEA:47178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + H2O => (2R)-hydroxybutanoyl-CoA
GO:0018630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-xylenol methylhydroxylase activity
REACT:R-DRE-437139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT6 transports zinc into the golgi apparatus (Danio rerio)
REACT:R-DDI-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Dictyostelium discoideum)
RHEA:68879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + piperonylate <=> AMP + diphosphate + NADP(+) + piperonal
GO:0102380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolbioside glucosyltransferase activity (rebaudioside B forming)
RHEA:37664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP
RHEA:56113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)
RHEA:44444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)
REACT:R-GGA-2473584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP15 (Gallus gallus)
RHEA:42349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)
RHEA:42701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-[ACP] methyl ester + H2O => 6-carboxyhexanoyl-[ACP] + H(+) + methanol
RHEA:35817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate => 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)
RHEA:65819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate
RHEA:41614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 2,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O
RHEA:62487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:46108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 = (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)
RHEA:63799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate
REACT:R-BTA-2318623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan binds Hyaluronan and HAPLN1 (Bos taurus)
RHEA:71360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) => 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)
RHEA:20181	skos:altLabel	"GlcPTase"
RHEA:20181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose derivative + UDP-alpha-D-glucose = 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP
RHEA:20181	skos:prefLabel	"UDP-glucose--glycoprotein glucose phosphotransferase"
RHEA:20181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-glucose--glycoprotein glucose phosphotransferase"
REACT:R-CFA-5690157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP16,USP21 deubiquitinate Histone H2A (Canis familiaris)
RHEA:52737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate => (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)
REACT:R-GGA-421158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthine + H2O + NAD+ => urate + NADH + H+ (Gallus gallus)
REACT:R-XTR-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Xenopus tropicalis)
REACT:R-HSA-9023178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (Homo sapiens)
REACT:R-XTR-9701531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727 STAT3 is acetylated (Xenopus tropicalis)
GO:0102332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acyl-[acp] elongase/decarboxylase activity
REACT:R-BTA-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Bos taurus)
RHEA:45482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+) => gamma-hexachlorocyclohexane
REACT:R-DME-8855825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTRA1 hydrolyzes ACAN (Aggrecan) (Drosophila melanogaster)
RHEA:52433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate
REACT:R-DRE-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Danio rerio)
REACT:R-CEL-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Caenorhabditis elegans)
RHEA:64793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NADP(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)
RHEA:65766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) => a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O
REACT:R-HSA-8853737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Homo sapiens)
REACT:R-CEL-749448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Caenorhabditis elegans)
REACT:R-HSA-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Homo sapiens)
REACT:R-GGA-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Gallus gallus)
REACT:R-SSC-5423647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2A13 oxidises AFM1 to AFM1E (Sus scrofa)
GO:0102864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:3-2-18:2-phosphatidylcholine desaturase activity
RHEA:63338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-xylose => alpha-D-xylose
RHEA:56840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-2-hydroxybenzoate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)
RHEA:56840	skos:prefLabel	"5-aminosalicylate 1,2-dioxygenase"
RHEA:56840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-aminosalicylate 1,2-dioxygenase"
RHEA:57662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:41141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O
EC:3.2.1.213	skos:prefLabel	"galactan exo-1,6-beta-galactobiohydrolase (non-reducing end)"
EC:3.2.1.213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactan exo-1,6-beta-galactobiohydrolase (non-reducing end)"
EC:3.2.1.213	skos:altLabel	"exo-beta-1,6-galactobiohydrolase"
REACT:R-DRE-193964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 21-hydroxylates PROG (Danio rerio)
RHEA:13453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin = adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate
RHEA:13453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonol 3-sulfotransferase"
RHEA:13453	skos:prefLabel	"flavonol 3-sulfotransferase"
GO:0016538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin-dependent protein serine/threonine kinase regulator activity
GO:0016538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Homo sapiens)
GO:0016538	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G1/S-specific cyclin
GO:0016538	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclin
GO:0016538	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G2/M-specific cyclin
GO:0016538	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclin-dependent protein kinase, intrinsic regulator activity
GO:0016538	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclin-dependent protein kinase regulator activity
REACT:R-GGA-216941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Chk1 by ATR (Gallus gallus)
RHEA:54154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in rRNA + S-adenosyl-L-methionine
REACT:R-CEL-8874745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Caenorhabditis elegans)
RHEA:61841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brassicasterol + UDP-alpha-D-glucose => brassicasterol 3-beta-D-glucoside + H(+) + UDP
RHEA:36616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine
RHEA:10465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O => n acetate + chitosan
GO:0035487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T/T mispair binding
GO:0035487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine/thymine mispair binding
REACT:R-MMU-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Mus musculus)
RHEA:35632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin + UDP-alpha-D-galactose => cyanidin 3-O-beta-D-galactoside + H(+) + UDP
RHEA:16913	skos:altLabel	"CDP-diglycerine-serine O-phosphatidyltransferase"
RHEA:16913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)
RHEA:16913	skos:prefLabel	"CDP-diacylglycerol--serine O-phosphatidyltransferase"
RHEA:16913	skos:altLabel	"phosphatidylserine synthase"
RHEA:16913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-diacylglycerol--serine O-phosphatidyltransferase"
REACT:R-GGA-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Gallus gallus)
REACT:R-SSC-3222006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STK11 (LKB1) phosphorylates NUAK1 (Sus scrofa)
REACT:R-XTR-8855954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Xenopus tropicalis)
GO:0044687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylfarnesyl diphosphate synthase activity
REACT:R-DRE-9603991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Danio rerio)
REACT:R-DRE-170964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 binds to active TrkA receptor (Danio rerio)
REACT:R-HSA-6784734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds LDLR (Homo sapiens)
GO:0004014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine carboxy-lyase activity
GO:0004014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosyl methionine decarboxylase activity
GO:0004014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylmethionine decarboxylase activity
GO:0004014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]
GO:0004014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine decarboxylase activity
GO:0004014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine decarboxylase activity
REACT:R-PFA-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Plasmodium falciparum)
RHEA:65992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + hnu = 5,6-trans-vitamin D3
RHEA:48673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:34911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methionine(in) = D-methionine(out)
RHEA:29418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(in) + H(+)(in) <=> (S)-lactate(out) + H(+)(out)
GO:0035885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exochitinase activity
GO:0018799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate carboxy-lyase activity
GO:0018799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoate decarboxylase activity
GO:0018799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate decarboxylase activity
GO:0018799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate carboxy-lyase (phenol-forming)
RHEA:37727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-RNO-2152276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of transmembrane collagens (Rattus norvegicus)
RHEA:18858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-416690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4A binds to PLXND1 (Drosophila melanogaster)
REACT:R-SCE-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Saccharomyces cerevisiae)
REACT:R-XTR-70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Xenopus tropicalis)
RHEA:57940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III
RHEA:18582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine + H2O + O2 => glycolaldehyde + H2O2 + NH4(+)
REACT:R-HSA-1168393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 association with GHR (Homo sapiens)
REACT:R-MMU-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Mus musculus)
RHEA:64343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one <=> 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate
REACT:R-RNO-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)
RHEA:64635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + butan-1-ol <=> butyl acetate + CoA
RHEA:32985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O
REACT:R-SSC-6781905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZRANB1 binds APC (Sus scrofa)
RHEA:65204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA + H2O = (R)-3-hydroxybutanoate + CoA + H(+)
REACT:R-SSC-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)
REACT:R-BTA-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Bos taurus)
RHEA:55395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in mRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:31950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)
RHEA:10869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA
REACT:R-HSA-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Homo sapiens)
REACT:R-SSC-159752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Sus scrofa)
REACT:R-DME-165127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEF binds to the inactive DRheb (Drosophila melanogaster)
REACT:R-MMU-8851900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1-2 bound to MET recruits GRB2:SOS1 (Mus musculus)
REACT:R-XTR-9607304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Xenopus tropicalis)
RHEA:54362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanal + CO2 => 4-methyl-2-oxopentanoate + H(+)
REACT:R-BTA-5662606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds zinc (Bos taurus)
REACT:R-SSC-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Sus scrofa)
RHEA:37849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daunorubicin + 2 H2O + NADP(+) => 13-dihydrodaunorubicin + H(+) + NADPH + O2
REACT:R-CEL-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Caenorhabditis elegans)
REACT:R-HSA-5333051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA1 binds HSF1 (Homo sapiens)
REACT:R-CEL-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Caenorhabditis elegans)
REACT:R-CFA-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Canis familiaris)
RHEA:61679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP <=> AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]
RHEA:29281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + menaquinone-8 + trimethylamine => H(+) + menaquinol-8 + trimethylamine N-oxide
REACT:R-HSA-2473184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follistatin (FST) binds Activin (Homo sapiens)
REACT:R-BTA-5654163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds PLCG1 (Bos taurus)
RHEA:63502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sulfinamide glutathione => H(+) + NADPH + S-nitrosoglutathione
REACT:R-BTA-5654677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR2 (Bos taurus)
REACT:R-MMU-4341048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RXRA with SUMO1 (Mus musculus)
RHEA:44202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyloctadecanoyl-CoA + AMP + diphosphate => 12-methyloctadecanoate + ATP + CoA
REACT:R-CFA-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Canis familiaris)
REACT:R-RNO-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Rattus norvegicus)
REACT:R-DRE-204798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and p85 of PI3K (Danio rerio)
REACT:R-GGA-399936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of integrin activation by sequestering PIP5KIgamma (Gallus gallus)
RHEA:66146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + melatonin => 5-methoxytryptamine + acetyl-CoA
REACT:R-HSA-74712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of IRS-P from insulin receptor (Homo sapiens)
RHEA:15711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + kaempferol 3-O-beta-D-galactoside + UDP => kaempferol + UDP-alpha-D-galactose
RHEA:16642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl ethyl ester + H2O => a long-chain fatty acid + ethanol + H(+)
RHEA:72114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) <=> L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)
RHEA:40573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-MMU-374214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CXCR4 and 7 bind CXCL12 ligand (Mus musculus)
RHEA:15340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phenylglyoxylyl-CoA <=> CoA + H(+) + phenylglyoxylate
REACT:R-XTR-9027532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DHA to 13-HDHA (Xenopus tropicalis)
RHEA:49521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 => an adenosine in mRNA + CO2 + formaldehyde + succinate
REACT:R-XTR-8875071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSS3 ligates CoA to CH3COO- (Xenopus tropicalis)
REACT:R-SSC-6799197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Sus scrofa)
RHEA:32298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH <=> 2 diphosphate + NADP(+) + squalene
REACT:R-MMU-266089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Discoidal HDL binds membrane-associated free cholesterol (Mus musculus)
REACT:R-HSA-9027531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA (Homo sapiens)
REACT:R-CFA-177942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EGF ligand (Canis familiaris)
REACT:R-HSA-9706336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SYK (Homo sapiens)
GO:0022839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion gated channel activity
RHEA:58049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA => 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA
GO:0070282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine binding
RHEA:14147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphoguanidinoacetate => ATP + guanidinoacetate
REACT:R-RNO-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Rattus norvegicus)
REACT:R-SSC-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Sus scrofa)
REACT:R-HSA-8949413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTMLYS translocates from the mitochondrial matrix to the cytosol (Homo sapiens)
REACT:R-MMU-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Mus musculus)
REACT:R-RNO-388503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxytocin receptor bind oxytocin (Rattus norvegicus)
RHEA:29015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(out) + sn-glycerol 3-phosphate(in) = phosphate(in) + sn-glycerol 3-phosphate(out)
RHEA:28157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
GO:0008171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)
GO:0008171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-methyltransferase activity
REACT:R-GGA-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Gallus gallus)
RHEA:69111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine
REACT:R-XTR-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Xenopus tropicalis)
REACT:R-DME-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Drosophila melanogaster)
GO:0140912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	membrane destabilizing activity
GO:0140912	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	antimicrobial peptide
RHEA:23260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH
RHEA:58493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Fe(III)-enterobactin(out) + H2O => ADP + Fe(III)-enterobactin(in) + H(+) + phosphate
REACT:R-SSC-9647660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds PIPs (Sus scrofa)
REACT:R-RNO-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)
RHEA:44710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine
RHEA:29400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ITP => diphosphate + H(+) + IMP
RHEA:28319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scutellarein + UDP-alpha-D-glucuronate => scutellarin + UDP
REACT:R-DRE-8852331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 translocates to the nucleus (Danio rerio)
RHEA:36305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a fatty acyl-CoA + 2 H(+) + 2 NADPH
RHEA:37307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-asparagine + H2O = glycine + L-asparagine
RHEA:31210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + hexanoyl-CoA <=> (2E)-hexenoyl-CoA + FADH2
RHEA:37846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-MMU-9640237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Mus musculus)
RHEA:49501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)
RHEA:68669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
RHEA:70040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
GO:2001069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	liver starch binding
GO:2001069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	animal starch binding
GO:2001069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen binding
REACT:R-BTA-1632843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1 binds DYNLL1,DYNLL2 (Bos taurus)
RHEA:41702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O
REACT:R-RNO-193684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 recruits an atypical PKC (Rattus norvegicus)
REACT:R-GGA-983703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-SYK phosphorylates BLNK (SLP65) (Gallus gallus)
RHEA:58909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH => C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)
RHEA:51613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + oxaloacetate => (R)-malate + 2-oxoglutarate
REACT:R-HSA-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Homo sapiens)
REACT:R-DME-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
RHEA:16249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-6-phosphate 1-epimerase"
RHEA:16249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate
RHEA:16249	skos:prefLabel	"glucose-6-phosphate 1-epimerase"
REACT:R-SSC-372519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcCho is hydrolyzed to Cho and acetate by ACHE (Sus scrofa)
REACT:R-CFA-937044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 (Canis familiaris)
REACT:R-CEL-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Caenorhabditis elegans)
RHEA:55700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O = an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate
REACT:R-RNO-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Rattus norvegicus)
REACT:R-XTR-5099899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD4 (Xenopus tropicalis)
REACT:R-DME-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)
REACT:R-CFA-6805479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53RK phosphorylates TP53 (Canis familiaris)
REACT:R-DME-549322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations out of hepatic cells (Drosophila melanogaster)
GO:0047347	skos:altLabel	"NDP-sugar phosphorylase"
GO:0047347	skos:prefLabel	"aldose-1-phosphate nucleotidyltransferase"
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDP:aldose-1-phosphate nucleotidyltransferase activity
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose 1-phosphate inosityltransferase activity
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDPaldose phosphorylase activity
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sugar phosphate nucleotidyltransferase activity
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDP-aldose phosphorylase activity
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside diphosphosugar phosphorylase activity
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sugar-1-phosphate nucleotidyltransferase activity
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sugar nucleotide phosphorylase activity
GO:0047347	skos:altLabel	"sugar-1-phosphate nucleotidyltransferase"
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDP sugar phosphorylase activity
GO:0047347	skos:altLabel	"NDP-aldose phosphorylase"
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NDP-sugar phosphorylase activity
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldose-1-phosphate nucleotidyltransferase"
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity
GO:0047347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldose-1-phosphate nucleotidyltransferase activity
RHEA:11670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O
RHEA:46737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + phosphate
REACT:R-HSA-480685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter (Homo sapiens)
RHEA:21647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycerol <=> ADP + H(+) + sn-glycerol 3-phosphate
GO:0032440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H-dependent alkenal/one oxidoreductase activity
GO:0032440	skos:altLabel	"NADPH:2-alkenal alpha,beta-hydrogenase"
GO:0032440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-alkenal reductase [NAD(P)(+)]"
GO:0032440	skos:prefLabel	"2-alkenal reductase [NAD(P)(+)]"
GO:0032440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-alkenal reductase [NAD(P)+] activity
GO:0032440	skos:altLabel	"NAD(P)H-dependent alkenal/one oxidoreductase"
GO:0032440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	n-alkanal:NAD(P)+ 2-oxidoreductase activity
GO:0032440	skos:altLabel	"2-alkenal reductase"
RHEA:59874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-CFA-112271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex dissociates (Canis familiaris)
REACT:R-HSA-352108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Homo sapiens)
REACT:R-MMU-8987161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Mus musculus)
REACT:R-RNO-5218806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN autophosphorylates (Rattus norvegicus)
REACT:R-MMU-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Mus musculus)
REACT:R-BTA-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Bos taurus)
RHEA:53665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) => H(+) + 2 H2O + pyridinestrone carboxylate
RHEA:67964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylamino-L-phenylalanine + S-adenosyl-L-methionine = 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine
RHEA:19295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + ATP
REACT:R-GGA-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Gallus gallus)
RHEA:50950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyuridine in single-stranded DNA + NH4(+) => a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O
RHEA:57671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-3244643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds cyclic GMP-AMP (Drosophila melanogaster)
REACT:R-XTR-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Xenopus tropicalis)
RHEA:37896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + protodioscin => 26-deglucoprotodioscin + D-glucose
RHEA:50445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 => prostaglandin G3
RHEA:29603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] = 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:29603	skos:prefLabel	"4-hydroxybenzoyl-CoA reductase"
RHEA:29603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoyl-CoA reductase"
REACT:R-MMU-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Mus musculus)
RHEA:35603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate
RHEA:33656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate(out) => (9Z)-octadecenoate(in)
RHEA:53519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DRE-1112703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 is phosphorylated (Danio rerio)
RHEA:12357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate => D-fructose 6-phosphate
RHEA:22310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + H2O2 => O2 + xylitol
RHEA:23667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a (2R)-2-hydroxycarboxylate <=> a 2-oxocarboxylate + AH2
RHEA:70287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)
REACT:R-MMU-374922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenalin synaptic vesicle docking and priming (Mus musculus)
REACT:R-RNO-420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretin receptor binds secretin (Rattus norvegicus)
REACT:R-GGA-4084984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Gallus gallus)
REACT:R-BTA-5668454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Bos taurus)
REACT:R-DME-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Drosophila melanogaster)
REACT:R-GGA-377640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of SRC (Gallus gallus)
REACT:R-HSA-9644926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency (Homo sapiens)
GO:0106080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GATOR1 complex binding
RHEA:18299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary amine + phthalate => a phtalamide + H2O
REACT:R-BTA-8985929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Bos taurus)
REACT:R-RNO-76466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4A11 12-hydroxylates DDCX (Rattus norvegicus)
RHEA:32364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate
RHEA:63497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrobenzaldehyde + H(+) + NADPH => 4-nitrobenzyl alcohol + NADP(+)
REACT:R-RNO-8943959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP9 cleave SCUBE3 (Rattus norvegicus)
RHEA:16309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chenodeoxycholoyltaurine hydrolase"
RHEA:16309	skos:prefLabel	"chenodeoxycholoyltaurine hydrolase"
RHEA:16309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + taurochenodeoxycholate = chenodeoxycholate + taurine
RHEA:29357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + phosphate => dUMP + H2O
REACT:R-HSA-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Homo sapiens)
RHEA:11858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP
REACT:R-SCE-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Saccharomyces cerevisiae)
REACT:R-CFA-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Canis familiaris)
RHEA:27760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+)
REACT:R-XTR-429663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-GGA-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Gallus gallus)
REACT:R-GGA-5692408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPR2 binds NPPC (Gallus gallus)
REACT:R-DDI-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Dictyostelium discoideum)
REACT:R-SSC-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Sus scrofa)
REACT:R-HSA-9014433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GEFs activate RHOG (Homo sapiens)
REACT:R-MMU-2029273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to p-6Y-SYK (Mus musculus)
RHEA:30817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-riboside + phosphate => beta-nicotinamide D-ribonucleotide + H2O
REACT:R-DRE-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Danio rerio)
REACT:R-HSA-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Homo sapiens)
REACT:R-MMU-2179276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 monoubiquitinates SMAD3 (Mus musculus)
RHEA:52432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate
GO:0008794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate reductase (glutaredoxin) activity
GO:0008794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutharedoxin:arsenate oxidoreductase activity
REACT:R-XTR-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Xenopus tropicalis)
RHEA:19624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 3'-phosphate + H(+)
RHEA:68208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA
REACT:R-CFA-5696131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC1 deaminates Hist (Canis familiaris)
RHEA:42446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + iminosuccinate + NADPH => L-aspartate + NADP(+)
REACT:R-XTR-9649108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer binds 5HT (Xenopus tropicalis)
RHEA:49609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH
RHEA:37422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-MMU-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Mus musculus)
RHEA:39368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)
REACT:R-MMU-9611852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB3 bind ADR,NAd (Mus musculus)
REACT:R-DRE-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Danio rerio)
RHEA:32355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"delphinidin 3',5'-O-glucosyltransferase"
RHEA:32355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + 2 UDP
RHEA:32355	skos:altLabel	"UDP-glucose:anthocyanin 3',5'-O-glucosyltransferase"
RHEA:32355	skos:prefLabel	"delphinidin 3',5'-O-glucosyltransferase"
REACT:R-HSA-1981128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Homo sapiens)
REACT:R-HSA-8862733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR2, CCR3 bind CCL13 (Homo sapiens)
GO:0043548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoinositide 3-kinase binding
GO:0043548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol 3-kinase binding
GO:0043548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binding
RHEA:21515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate
RHEA:35773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-hydroxybenzoate + H(+) + H2O => 5-deoxy-5-amino-3-dehydroshikimate
REACT:R-MMU-8983371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Mus musculus)
REACT:R-RNO-8850945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates PTEN (Rattus norvegicus)
REACT:R-BTA-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Bos taurus)
RHEA:67951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP
REACT:R-RNO-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Rattus norvegicus)
RHEA:43358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z,12Z)-octadecadienoate(out) => cholesteryl (9Z,12Z)-octadecadienoate(in)
RHEA:43621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NADP(+) => aminoacetaldehyde + CO2 + NADPH
REACT:R-CFA-2129357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin C-terminal processing (Canis familiaris)
RHEA:58631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV <=> FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal
RHEA:23761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) => reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:71919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + succinate(out) = 3 Na(+)(in) + succinate(in)
RHEA:30554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + beta-D-glucose <=> 6-O-acetyl-beta-D-glucose + CoA
RHEA:44066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + octyl hexadecanoyl => hexadecanoyl-CoA + octan-1-ol
REACT:R-HSA-5685953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates RBBP8 (Homo sapiens)
RHEA:59871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine <=> 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)
GO:0042279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite reductase (cytochrome, ammonia-forming) activity
GO:0042279	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonia:ferricytochrome-c oxidoreductase activity
GO:0042279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	multiheme nitrite reductase activity
GO:0042279	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite reductase (cytochrome; ammonia-forming)
GO:0042279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome c nitrite reductase activity
GO:0042279	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome c552 activity
RHEA:68065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1791167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SERP1 (RAMP4) (Homo sapiens)
RHEA:40022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate + H2O <=> (-)-ent-copalol + diphosphate
RHEA:57239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GMP
REACT:R-XTR-169895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk's SH3 domain engages C3G (Xenopus tropicalis)
RHEA:24248	skos:altLabel	"alanine--glyoxylate aminotransferase"
RHEA:24248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-alanine = glycine + pyruvate
RHEA:24248	skos:altLabel	"AGT"
RHEA:24248	skos:prefLabel	"alanine--glyoxylate transaminase"
RHEA:24248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alanine--glyoxylate transaminase"
RHEA:66497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
RHEA:15556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4-bisphosphate + H2O <=> 1D-myo-inositol 4-phosphate + phosphate
REACT:R-RNO-933533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of p-IRF7 (Rattus norvegicus)
RHEA:66990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanoyl-CoA + AMP + diphosphate => 4-methylpentanoate + ATP + CoA
REACT:R-DRE-9632918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Danio rerio)
RHEA:32890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + O2 <=> 2 all-trans-retinal
REACT:R-HSA-8876191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 GEFs exchange GTP for GDP on RAB9 (Homo sapiens)
REACT:R-PFA-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Plasmodium falciparum)
GO:0071111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	c-di-GMP-specific phosphodiesterase activity
GO:0071111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDEA1
GO:0071111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-guanylate-specific phosphodiesterase activity
GO:0071111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	c-di-GMP phosphodiesterase activity
GO:0071111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	VieA
GO:0071111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic bis(3->5')diguanylate phosphodiesterase activity
GO:0071111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphodiesterase A1 activity
RHEA:64822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + NH4(+) => 2-phenylacetamide + H2O
RHEA:18937	skos:altLabel	"N-acyl-homoserine lactone acylase"
RHEA:18937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-homoserine-lactone acylase"
RHEA:18937	skos:altLabel	"AHL-acylase"
RHEA:18937	skos:prefLabel	"acyl-homoserine-lactone acylase"
RHEA:18937	skos:altLabel	"acyl-homoserine lactone acylase"
RHEA:18937	skos:altLabel	"quorum-quenching AHL acylase"
RHEA:18937	skos:altLabel	"quorum-quenching enzyme"
RHEA:18937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-homoserine lactone + H2O = a carboxylate + L-homoserine lactone
GO:0036312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K regulatory subunit binding
GO:0036312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol 3-kinase regulatory subunit binding
GO:0036312	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p85 binding
REACT:R-DRE-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Danio rerio)
REACT:R-CEL-8874078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Caenorhabditis elegans)
GO:0042654	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ecdysis-triggering hormone binding
GO:0042654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETH receptor
GO:0042654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysis-triggering hormone receptor activity
REACT:R-BTA-6798374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DYRK2 phosphorylates TP53 (Bos taurus)
RHEA:70549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose
RHEA:66575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-naphthol + 3'-phosphoadenylyl sulfate <=> 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-XTR-5688289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Xenopus tropicalis)
REACT:R-RNO-2161961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EET(1) is hydrolysed to DHET(1) by EPHX2 (Rattus norvegicus)
RHEA:19697	skos:prefLabel	"11-cis-retinyl-palmitate hydrolase"
RHEA:19697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"11-cis-retinyl-palmitate hydrolase"
RHEA:19697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate
REACT:R-RNO-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Rattus norvegicus)
GO:0031872	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 proteinase activated receptor ligand
GO:0031872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin receptor binding
GO:0031872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 proteinase activated receptor binding
REACT:R-RNO-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Rattus norvegicus)
RHEA:36569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH => GDP-beta-L-colitose + NAD(+)
REACT:R-BTA-8943987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCUBE1, SCUBE3 oligomerize (Bos taurus)
REACT:R-SSC-1358798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 binds neuregulin-activated ERBB3 (Sus scrofa)
RHEA:44429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol
RHEA:27846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)
REACT:R-DME-4332363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation and activation of CAMK2 (Drosophila melanogaster)
REACT:R-SSC-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Sus scrofa)
RHEA:15632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]
REACT:R-BTA-8855747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Bos taurus)
RHEA:35654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + a fatty acyl-CoA <=> an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)
RHEA:51442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2
RHEA:72144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + GTP + S-adenosyl-L-methionine => 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine
GO:0003861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-IPM isomerase activity
GO:0003861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R,3S)-3-isopropylmalate hydro-lyase activity
GO:0003861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
GO:0003861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopropylmalate isomerase activity
GO:0003861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-isopropylmalate dehydratase activity
GO:0003861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-isopropylmalate dehydratase activity
GO:0003861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-isopropylmalate isomerase activity
REACT:R-HSA-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Homo sapiens)
REACT:R-CEL-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Caenorhabditis elegans)
REACT:R-XTR-5660980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S276-RELA binds RELB (Xenopus tropicalis)
RHEA:46834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH
REACT:R-DDI-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Dictyostelium discoideum)
RHEA:70113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-173542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 ubiquitinates SMAD2 (Gallus gallus)
RHEA:58566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate II + 2 H(+) + NADPH => 15alpha-stemmadenine + NADP(+)
REACT:R-MMU-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Mus musculus)
RHEA:14755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]
GO:0008926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannitol-1-phosphate 5-dehydrogenase activity
RHEA:36938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:64321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + cholesterol => cholesteryl (9Z)-hexadecenoate + CoA
RHEA:13110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetamidofluorene + H2O + NAD(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADH
RHEA:15712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + UDP-alpha-D-galactose <=> H(+) + kaempferol 3-O-beta-D-galactoside + UDP
REACT:R-GGA-8948800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNKS and TNKS2 PARylate PTEN (Gallus gallus)
GO:0044668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:malonate symporter activity
GO:0044668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(in) + Na(+)(in) = malonate(out) + Na(+)(out)
RHEA:69046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + H(+) + nitrite => 2-nitrobutanedioate
REACT:R-HSA-174251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Homo sapiens)
REACT:R-CFA-5669250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates FLNA (Canis familiaris)
REACT:R-MMU-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Mus musculus)
REACT:R-RNO-9625813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P binds S1PR3 in response to E2 stimulation (Rattus norvegicus)
RHEA:61258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+) => H2O + L-cysteine + O2
RHEA:26510	skos:altLabel	"S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase"
RHEA:26510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-proline amide hydrolase"
RHEA:26510	skos:altLabel	"L-amino acid amidase"
RHEA:26510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-prolinamide = L-proline + NH4(+)
RHEA:26510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-piperazine-2-carboxamide + H2O = (S)-piperazine-2-carboxylate + NH4(+)
RHEA:26510	skos:prefLabel	"L-proline amide hydrolase"
RHEA:30853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + dihydroxyacetone phosphate => beta-D-fructose 1-phosphate
REACT:R-RNO-72619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2:GTP is hydrolyzed, eIFs are released  (Rattus norvegicus)
REACT:R-CFA-419843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCR (Canis familiaris)
REACT:R-CFA-190385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3b (Canis familiaris)
REACT:R-GGA-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Gallus gallus)
RHEA:35363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH = isopentadecanoyl-CoA + NADP(+)
REACT:R-BTA-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Bos taurus)
REACT:R-SSC-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Sus scrofa)
REACT:R-SSC-5682826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM11 (Sus scrofa)
REACT:R-CFA-2562594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated OPTN translocates to the nucleus (Canis familiaris)
REACT:R-SSC-197250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)
REACT:R-HSA-9686711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytois of SARS-CoV-1 Virion (Homo sapiens)
REACT:R-DME-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Drosophila melanogaster)
REACT:R-DME-9624120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK2 (Drosophila melanogaster)
REACT:R-MMU-5653754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Mus musculus)
REACT:R-MMU-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)
RHEA:11445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate
RHEA:11824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate
RHEA:11824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-methyl-2-oxobutanoate hydroxymethyltransferase"
RHEA:11824	skos:prefLabel	"3-methyl-2-oxobutanoate hydroxymethyltransferase"
RHEA:11824	skos:altLabel	"ketopantoate hydroxymethyltransferase"
RHEA:11824	skos:altLabel	"alpha-ketoisovalerate hydroxymethyltransferase"
RHEA:11824	skos:altLabel	"dehydropantoate hydroxymethyltransferase"
REACT:R-BTA-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Bos taurus)
RHEA:59766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA
RHEA:21016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-asparagine = L-aspartate + NH4(+)
REACT:R-DDI-8876616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND6A,B exchange GTP for GDP on RAB14 (Dictyostelium discoideum)
REACT:R-HSA-8986995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Homo sapiens)
REACT:R-PFA-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
RHEA:29898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine(out) <=> ADP + H(+) + L-glutamine(in) + phosphate
REACT:R-HSA-9692738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds HRH2 antagonists (Homo sapiens)
REACT:R-GGA-5686073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-3Y-SHC1 (Gallus gallus)
REACT:R-XTR-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Xenopus tropicalis)
REACT:R-XTR-5668543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3:NIK binds TRAF2:cIAP1/2 (Xenopus tropicalis)
RHEA:53948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[BtrI ACP] + L-glutamate = ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate
REACT:R-DRE-8934742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRMT1 (Danio rerio)
REACT:R-XTR-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Xenopus tropicalis)
RHEA:36623	skos:altLabel	"phenylpyruvate Cbeta-methyltransferase"
RHEA:36623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + S-adenosyl-L-methionine = (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine
RHEA:36623	skos:prefLabel	"phenylpyruvate C(3)-methyltransferase"
RHEA:36623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylpyruvate C(3)-methyltransferase"
RHEA:36623	skos:altLabel	"phenylpyruvate methyltransferase"
REACT:R-CFA-1295604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-RAF dissociates from S111/S120 p-SPRY2 (Canis familiaris)
RHEA:39530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)
REACT:R-BTA-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Bos taurus)
RHEA:28422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28422	skos:prefLabel	"(E)-2-methylbutanal oxime monooxygenase"
RHEA:28422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28422	skos:altLabel	"CYP71E7"
RHEA:28422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(E)-2-methylbutanal oxime monooxygenase"
REACT:R-RNO-202703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD47 binds SIRP (Rattus norvegicus)
GO:0102426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin-3-O-glucoside 1,6-glucosyltransferase activity
REACT:R-SSC-5432814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR2:TLR1 (Sus scrofa)
REACT:R-MMU-9661397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)
REACT:R-HSA-9700648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds SRC (Homo sapiens)
RHEA:17736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylenedicarboxylate + H(+) + H2O <=> CO2 + pyruvate
REACT:R-SSC-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Sus scrofa)
RHEA:37777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA
REACT:R-MMU-186826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to the active receptor (Mus musculus)
REACT:R-HSA-5667107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIAH1, SIAH2 ubiquitinate SNCAIP (Homo sapiens)
REACT:R-MMU-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Mus musculus)
REACT:R-MMU-1247497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds neuregulins (Mus musculus)
RHEA:55159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione
REACT:R-HSA-451418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates IRAK1 (Homo sapiens)
REACT:R-DRE-500717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GRIK3 homomer (Danio rerio)
RHEA:43489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyll a + NAD(+) => chlorophyll b + H(+) + NADH
REACT:R-SSC-139895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAK protein (Sus scrofa)
RHEA:30684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-D-mannosamine + UDP
REACT:R-XTR-8938431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 and BTN1A1 binds periplakin (PPL) (Xenopus tropicalis)
REACT:R-BTA-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Bos taurus)
RHEA:71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-methionine(out) + 2 Na(+)(out) <=> chloride(in) + L-methionine(in) + 2 Na(+)(in)
RHEA:39749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol(out) => cholesterol(in)
REACT:R-DME-8940070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NAD+ (Drosophila melanogaster)
GO:0015611	skos:prefLabel	"ABC-type D-allose transporter"
GO:0015611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type D-ribose transporter activity
GO:0015611	skos:altLabel	"D-allose ABC transporter"
GO:0015611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type D-allose transporter"
GO:0015611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-allose(out) + H2O = ADP + D-allose(in) + H(+) + phosphate
GO:0015611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribose-importing ATPase activity
GO:0015611	skos:altLabel	"D-allose transporting ATPase"
GO:0015611	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-ribose porter activity
REACT:R-MMU-5669250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates FLNA (Mus musculus)
RHEA:17359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + R'C(R)S-S(R)CR' => O2 + 2 R'C(R)SH
RHEA:64407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine(out) + H(+)(out) <=> carnosine(in) + H(+)(in)
RHEA:65438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate => a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+)
EC:1.14.13.135	skos:prefLabel	"1-hydroxy-2-naphthoate hydroxylase"
EC:1.14.13.135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-hydroxy-2-naphthoate hydroxylase"
EC:1.14.13.135	skos:altLabel	"1-hydroxy-2-naphthoic acid hydroxylase"
REACT:R-XTR-6787321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DERA cleaves dR5P to GA3P and CH3CHO (Xenopus tropicalis)
REACT:R-SPO-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Schizosaccharomyces pombe)
RHEA:44770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2 => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+)
RHEA:51335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate
REACT:R-BTA-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Bos taurus)
RHEA:67923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)
REACT:R-HSA-193399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholate is translocated from the peroxisomal matrix to the cytosol (Homo sapiens)
REACT:R-XTR-213175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 oxidise AFB1 to AFXBO (Xenopus tropicalis)
RHEA:65666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + 4 Na(+)(in) => citrate(out) + 4 Na(+)(out)
RHEA:58452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-GGA-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Gallus gallus)
REACT:R-BTA-9640237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Bos taurus)
GO:0034874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioacetamide S-oxide S-oxygenase activity
REACT:R-RNO-2404135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4 binds atROL (Rattus norvegicus)
REACT:R-MMU-141341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMOX-3 oxidises SPN to SPM (Mus musculus)
RHEA:34554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(II)yrinate c monoamide + H2O + L-glutamine <=> ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate
REACT:R-HSA-158766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Homo sapiens)
GO:0008880	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uronic acid isomerase activity
GO:0008880	skos:altLabel	"uronate isomerase"
GO:0008880	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uronic isomerase activity
GO:0008880	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucuronate ketol-isomerase activity
GO:0008880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronate isomerase"
GO:0008880	skos:prefLabel	"glucuronate isomerase"
GO:0008880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronate isomerase activity
GO:0008880	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucuronate aldose-ketose-isomerase activity
GO:0008880	skos:altLabel	"uronic acid isomerase"
GO:0008880	skos:altLabel	"uronic isomerase"
GO:0008880	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uronate isomerase activity
GO:0008880	skos:altLabel	"D-glucuronate isomerase"
GO:0008880	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucuronate isomerase activity
REACT:R-DRE-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)
RHEA:15013	skos:altLabel	"strictosidine synthetase"
RHEA:15013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"strictosidine synthase"
RHEA:15013	skos:altLabel	"STR"
RHEA:15013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha(S)-strictosidine + H2O = secologanin + tryptamine
RHEA:15013	skos:prefLabel	"strictosidine synthase"
REACT:R-SSC-9627106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) forms dimer (Sus scrofa)
REACT:R-BTA-8871266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD3 (Bos taurus)
REACT:R-DDI-8854209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A binds JFC1 (Dictyostelium discoideum)
GO:0035489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G/G mispair binding
GO:0035489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine/guanine mispair binding
REACT:R-HSA-8961952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 gene expression is stimulated by E2F1 (Homo sapiens)
REACT:R-XTR-162730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Xenopus tropicalis)
REACT:R-DDI-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Dictyostelium discoideum)
REACT:R-DME-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Drosophila melanogaster)
RHEA:42568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-p-cumate + O2 = 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)
REACT:R-CFA-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Canis familiaris)
REACT:R-RNO-3341277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
REACT:R-CFA-2301205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 monomethylates histone H4 (Canis familiaris)
REACT:R-MMU-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Mus musculus)
RHEA:58511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O <=> (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
RHEA:44025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O
REACT:R-GGA-9614271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ADGRG6 (Gallus gallus)
GO:0009033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH:trimethylamine-N-oxide oxidoreductase
GO:0009033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine-N-oxide reductase activity
GO:0009033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine oxidase activity
GO:0009033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine N-oxide reductase
GO:0009033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine oxide reductase
GO:0009033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + trimethylamine = 2 H(+) + NADH + trimethylamine N-oxide
REACT:R-DME-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-SSC-139908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DLC2 by MAPK8 (Sus scrofa)
REACT:R-XTR-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Xenopus tropicalis)
REACT:R-SSC-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Sus scrofa)
RHEA:50993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thromboxane B2(out) => thromboxane B2(in)
RHEA:53107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + S-adenosyl-L-methionine <=> 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine
RHEA:54820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-DDI-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Dictyostelium discoideum)
GO:0001664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GRIK3 homomer (Homo sapiens)
GO:0001664	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G-protein-coupled receptor ligand
GO:0001664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled receptor binding
GO:0001664	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G protein coupled receptor ligand
GO:0001664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled receptor binding
GO:0001664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled receptor binding
REACT:R-MMU-433711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-homodimerization of nectins (Mus musculus)
REACT:R-HSA-1168637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK (Homo sapiens)
REACT:R-XTR-8871226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA2 (Xenopus tropicalis)
RHEA:56529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + D-tryptophan + FADH2 + O2 => 6-chloro-D-tryptophan + FAD + 2 H2O
RHEA:72418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Li(+)(in) + Na(+)(out) <=> Li(+)(out) + Na(+)(in)
GO:0051566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanidin-3-glucoside rhamnosyltransferase activity
GO:0051566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanidin 3-glucoside-rhamnosyltransferase activity
GO:0051566	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3RT activity
REACT:R-BTA-5660666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBP and p300 binds NF-kB complex (Bos taurus)
REACT:R-RNO-8948018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Rattus norvegicus)
RHEA:65919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + pyruvate <=> H2O + kynurenate + L-alanine
GO:1990088	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methylcobamide:CoM methyltransferase activity
GO:1990088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol-specific methylcobalamin: coenzyme M methyltransferase activity
GO:1990088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol-specific methylcobalamin:CoM methyltransferase activity
GO:1990088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase
GO:1990088	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methylcobamide:coenzyme M methyltransferase activity
GO:1990088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol-specific methylcobalamin:coenzyme M methyltransferase activity
RHEA:47453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5Z)-tetradecadienoyl-CoA + H2O => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA
RHEA:18636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + H2O + hydrogencarbonate + L-glutamine <=> 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate
RHEA:30760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytosine + H(+) + H2O => NH4(+) + thymine
GO:0004842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-protein transferase activity
GO:0004842	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin protein ligase activity
GO:0004842	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	anaphase-promoting complex activity
GO:0004842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0004842	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin-conjugating enzyme activity
GO:0004842	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin ligase activity
GO:0004842	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin protein-ligase activity
GO:0004842	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin conjugating enzyme activity
GO:0004842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
REACT:R-HSA-1839065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cytosolic FGFR1 fusion dimers (Homo sapiens)
RHEA:34526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:43588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NORint + UDP-alpha-D-galactose = globoside NOR2 + H(+) + UDP
GO:0001042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase I core binding
RHEA:38172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecane-1,2-diol + hexadecanoyl-CoA => 2-hydroxyhexadecyl hexadecanoate + CoA
RHEA:71375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + testosterone 17-sulfate(out) = 2 Na(+)(in) + testosterone 17-sulfate(in)
RHEA:69967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)
REACT:R-DRE-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Danio rerio)
REACT:R-BTA-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Bos taurus)
REACT:R-GGA-5577234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Gallus gallus)
RHEA:64265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrochrysone carboxylate + H(+) => atrochrysone + CO2
REACT:R-DRE-2203480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC11 binds ligands (Danio rerio)
RHEA:69534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate => (2S)-2-amino-4-deoxychorismate
RHEA:36947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA
REACT:R-DME-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Drosophila melanogaster)
REACT:R-SSC-4332236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL neddylates TGFBR2 (Sus scrofa)
REACT:R-CEL-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Caenorhabditis elegans)
REACT:R-MMU-109380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Mus musculus)
REACT:R-HSA-187678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 (Homo sapiens)
REACT:R-CEL-2514867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Caenorhabditis elegans)
RHEA:33629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + decanoyl-CoA + diphosphate => ATP + CoA + decanoate
RHEA:51245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
RHEA:29581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(out) + H(+)(out) => Fe(2+)(in) + H(+)(in)
REACT:R-RNO-1358789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Self-ubiquitination of RNF41 (Rattus norvegicus)
RHEA:57538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NTP-ribonucleotide-RNA + AMP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate
REACT:R-XTR-5610732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI3 (Xenopus tropicalis)
RHEA:64273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylamine + pyruvate => benzaldehyde + L-alanine
REACT:R-RNO-508162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Rattus norvegicus)
REACT:R-HSA-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Homo sapiens)
RHEA:29674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) <=> Ca(2+)(out)
GO:0016429	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate adenine 1-methyltransferase activity
GO:0016429	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer RNA (adenine-1) methyltransferase activity
GO:0016429	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity
GO:0016429	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenine-1-methylase activity
GO:0016429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (adenine-N1-)-methyltransferase activity
GO:0016429	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-methyladenine transfer RNA methyltransferase activity
GO:0016429	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity
RHEA:52115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
REACT:R-SSC-166220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion diffuses laterally to UCP (Sus scrofa)
REACT:R-MMU-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Mus musculus)
REACT:R-DME-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Drosophila melanogaster)
RHEA:50089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:61074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-(R)-19-O-acetyltabersonine + CoA => (-)-(R)-19-hydroxytabersonine + acetyl-CoA
RHEA:41284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoate
REACT:R-MMU-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Mus musculus)
REACT:R-XTR-73596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)
RHEA:34793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) + hydroxymethylphosphonate => 2-hydroxyethylphosphonate + O2
RHEA:48838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2
RHEA:19911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate => (S)-lactate + 2 Fe(III)-[cytochrome c]
REACT:R-CEL-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Caenorhabditis elegans)
REACT:R-HSA-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Homo sapiens)
REACT:R-MMU-5682084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Mus musculus)
GO:0034926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrene-4,5-epoxide hydrolase activity
REACT:R-BTA-8870489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA4,(5,6) bind PI3P (Bos taurus)
REACT:R-DME-186826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to the active receptor (Drosophila melanogaster)
REACT:R-DME-8862380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B13 binds lipid droplets (Drosophila melanogaster)
REACT:R-DME-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Drosophila melanogaster)
RHEA:15407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n+1) + CoA => (3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n)
REACT:R-HSA-6807144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Homo sapiens)
REACT:R-HSA-9008285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Homo sapiens)
REACT:R-GGA-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Gallus gallus)
REACT:R-XTR-982775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor dimerizes (Xenopus tropicalis)
REACT:R-XTR-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Xenopus tropicalis)
REACT:R-BTA-201445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Bos taurus)
GO:0102692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyladenine UDP glycosyltransferase activity
REACT:R-SSC-9701488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates JAK3 (Sus scrofa)
RHEA:59490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate
GO:0004349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate kinase activity
GO:0004349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamyl kinase activity
GO:0004349	skos:prefLabel	"glutamate 5-kinase"
GO:0004349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate = ADP + L-glutamyl 5-phosphate
GO:0004349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-L-glutamate 5-phosphotransferase activity
GO:0004349	skos:altLabel	"gamma-glutamyl kinase"
GO:0004349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate 5-kinase activity
GO:0004349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamate kinase activity
GO:0004349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate 5-kinase"
GO:0004349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:L-glutamate 5-phosphotransferase activity
GO:0004349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:gamma-L-glutamate phosphotransferase activity
RHEA:42313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [adrenodoxin] => NADPH + 2 oxidized [adrenodoxin]
REACT:R-SSC-5334794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABPs bind LCFAs (Sus scrofa)
RHEA:12497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(2+) + 4 H2O + O2 => 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide
REACT:R-HSA-2408509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec-tRNA(Sec) binds to EEFSEC:GTP (Homo sapiens)
REACT:R-SPO-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Schizosaccharomyces pombe)
REACT:R-CEL-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Caenorhabditis elegans)
GO:0003746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation elongation factor activity
REACT:R-MMU-5693742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH hydrolyses AEA to AA and ETA (Mus musculus)
RHEA:22705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + ricinine => 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)
REACT:R-CFA-913451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3RB is phosphorylated on Ser-585 (Canis familiaris)
RHEA:43934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-ene-3,17-dione + H(+) + NADH => 3beta-hydroxyandrost-5-en-17-one + NAD(+)
REACT:R-DRE-8938076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD38 hydrolyses NAD+ to NAM and ADP-ribose (Danio rerio)
RHEA:12353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulono-1,4-lactone + O2 => H2O2 + L-xylo-hex-3-ulonolactone
RHEA:51418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3R)-flavan-3-ol + 2 NADP(+)
REACT:R-DRE-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Danio rerio)
REACT:R-BTA-75083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Bos taurus)
RHEA:54203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:21008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH
RHEA:21008	skos:prefLabel	"diethyl 2-methyl-3-oxosuccinate reductase"
RHEA:21008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diethyl 2-methyl-3-oxosuccinate reductase"
REACT:R-HSA-6787566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser) (Homo sapiens)
REACT:R-RNO-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Rattus norvegicus)
RHEA:36321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + 2 NADP(+) + octadecan-1-ol => 2 H(+) + 2 NADPH + octadecanoyl-CoA
REACT:R-HSA-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Homo sapiens)
RHEA:25292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H(+) + NADH => ethanol + NAD(+)
REACT:R-DME-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Drosophila melanogaster)
REACT:R-XTR-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Xenopus tropicalis)
RHEA:58857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-oxogeraniol + H(+) + NADH
RHEA:31467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-glucosyl) crocetin + UDP
RHEA:50745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glyphosate + O2 => 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)
GO:0019238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohydrolase activity
REACT:R-MMU-159729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)
REACT:R-SSC-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Sus scrofa)
REACT:R-MMU-416985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to synapse (Mus musculus)
REACT:R-MMU-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Mus musculus)
REACT:R-DDI-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
RHEA:42002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose
RHEA:63346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-threonyl-[protein]
RHEA:42267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + octanoyl-CoA <=> 3-oxodecanoyl-[ACP] + CO2 + CoA
REACT:R-SSC-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Sus scrofa)
RHEA:15476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP
REACT:R-CFA-73646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Canis familiaris)
RHEA:71465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-L-Leu-L-Met-NH2 + substance P(1-8) => H2O + substance P
GO:0070009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-type aminopeptidase activity
RHEA:42210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+) => a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2
RHEA:56014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)
REACT:R-PFA-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Plasmodium falciparum)
REACT:R-HSA-5655268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 mutants phosphorylate FRS2 (Homo sapiens)
RHEA:25236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-neuraminate <=> N-acetyl-beta-neuraminate
REACT:R-CFA-8865994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds PTPN11 (Canis familiaris)
REACT:R-HSA-5696049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRM hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)
REACT:R-DRE-5654637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)
REACT:R-GGA-1474210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP14 (Gallus gallus)
REACT:R-MMU-417842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 receptor can bind to LPA (Mus musculus)
RHEA:67442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-methionine => H2O + N(alpha)-acetyl-L-methionine
REACT:R-BTA-8855375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dissociates from CSK (Bos taurus)
REACT:R-HSA-388808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-2 monomer (Homo sapiens)
REACT:R-DRE-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Danio rerio)
EC:7.4.2.2	skos:prefLabel	"ABC-type nonpolar-amino-acid transporter"
EC:7.4.2.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type nonpolar-amino-acid transporter"
EC:7.4.2.2	skos:altLabel	"nonpolar-amino-acid-transporting ATPase"
GO:0005011	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CSF-1
GO:0005011	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Fms
GO:0005011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrophage colony-stimulating factor receptor activity
GO:0005011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M-CSF receptor activity
GO:0005011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrophage colony stimulating factor receptor activity
REACT:R-DRE-5688289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Danio rerio)
REACT:R-DME-2730842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)
REACT:R-BTA-69140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap (Bos taurus)
GO:0102786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stearoyl-[acp] desaturase activity
REACT:R-MMU-448744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20RA binds IL20RB (Mus musculus)
REACT:R-DRE-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Danio rerio)
REACT:R-BTA-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Bos taurus)
REACT:R-MMU-201810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ligand trap binds the ligand BMP2, blocking BMP signalling (Mus musculus)
REACT:R-XTR-6803761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Xenopus tropicalis)
REACT:R-BTA-5690046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT2 hydrolyses PALMCoA to PALM (Bos taurus)
REACT:R-HSA-9665706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1 (Homo sapiens)
REACT:R-SSC-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Sus scrofa)
REACT:R-MMU-390438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR2 reduces PalmCoA to HXOL (Mus musculus)
RHEA:28560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + phosphate => D-fructose 6-phosphate + H2O
RHEA:49356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-5654587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS phosphorylates PPTN11 (Mus musculus)
REACT:R-DRE-5660665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 binds MALT (Danio rerio)
REACT:R-DDI-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Dictyostelium discoideum)
REACT:R-DME-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Drosophila melanogaster)
RHEA:60353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-3-hydroxy-4(1H)-quinolone + O2 => CO + H(+) + N-octanoylanthranilate
REACT:R-XTR-167427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid dissociates from MOR (Xenopus tropicalis)
RHEA:36294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine
REACT:R-XTR-6813626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEAP2 binds bacteria (Xenopus tropicalis)
REACT:R-DME-3791319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NID1 degradation by MMP19 (Drosophila melanogaster)
REACT:R-HSA-1989761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of APOA5 (Homo sapiens)
REACT:R-SPO-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Schizosaccharomyces pombe)
REACT:R-CFA-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Canis familiaris)
REACT:R-GGA-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Gallus gallus)
RHEA:31896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => alpha-humulene + diphosphate
REACT:R-XTR-9006850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor JAK phosphorylation (Xenopus tropicalis)
REACT:R-MMU-444171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR2 binds carboxylates (Mus musculus)
REACT:R-SSC-168140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Sus scrofa)
RHEA:30686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-D-mannosamine + UDP
RHEA:55274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinyl tetradecanoate + CoA => 11-cis-retinol + tetradecanoyl-CoA
GO:0047681	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-alcohol:NADP+ oxidoreductase activity
GO:0047681	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)
GO:0047681	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-linked benzaldehyde reductase activity
GO:0047681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryl-alcohol dehydrogenase (NADP+) activity
RHEA:53281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threose => D-erythrulose
RHEA:12146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-rutinoside + UDP-alpha-D-glucose
REACT:R-CFA-9727188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B binds PPIs (Canis familiaris)
RHEA:25747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:32804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + urea(out) => ADP + H(+) + phosphate + urea(in)
GO:0018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene-1,2-epoxide hydrolase activity
REACT:R-CFA-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)
RHEA:20410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + riboflavin => D-glucose + FMN
REACT:R-DME-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)
RHEA:30271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O
RHEA:49745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyviolaceinate + H(+) + O2 => CO2 + deoxyviolacein + H2O
RHEA:63363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2
REACT:R-MMU-9029517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Mus musculus)
RHEA:33907	skos:prefLabel	"4-methylaminobutanoate oxidase (formaldehyde-forming)"
RHEA:33907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-methylaminobutanoate oxidase (formaldehyde-forming)"
RHEA:33907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(methylamino)butanoate + H2O + O2 = 4-aminobutanoate + formaldehyde + H2O2
RHEA:58574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + precondylocarpine acetate => O-acetyl-15alpha-stemmadenine + O2
GO:0102003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta8-sphingolipid desaturase activity
RHEA:46042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dCMP + H(+) => 2'-deoxycytidine + ATP
REACT:R-SCE-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Saccharomyces cerevisiae)
REACT:R-MMU-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Mus musculus)
RHEA:22080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyquinoline 8-monooxygenase"
RHEA:22080	skos:altLabel	"2-oxo-1,2-dihydroquinoline 8-monooxygenase"
RHEA:22080	skos:prefLabel	"2-hydroxyquinoline 8-monooxygenase"
RHEA:22080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + quinolin-2-ol = H2O + NAD(+) + quinoline-2,8-diol
REACT:R-SSC-198870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Sus scrofa)
RHEA:34545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-HSA-6801184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates STEAP3 expression (Homo sapiens)
REACT:R-GGA-2203480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC11 binds ligands (Gallus gallus)
RHEA:66651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> african-3-ene + diphosphate
RHEA:37703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
RHEA:72484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + citrate(out) => (S)-malate(out) + citrate(in)
RHEA:25340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocyanate + NH4(+) => H(+) + urea
RHEA:29247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+)(out) + 2 Na(+)(in) = 3 H(+)(in) + 2 Na(+)(out)
RHEA:41629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + H2O => cyclooctat-9-en-7-ol + diphosphate
REACT:R-CFA-193792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Canis familiaris)
REACT:R-HSA-201519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK:PTN dimerization (Homo sapiens)
REACT:R-XTR-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Xenopus tropicalis)
RHEA:19797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate
REACT:R-HSA-2066780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Homo sapiens)
REACT:R-BTA-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Bos taurus)
RHEA:16361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate
RHEA:16361	skos:altLabel	"acetohydroxy acid isomerase"
RHEA:16361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-acetolactate mutase"
RHEA:16361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ethyl-2-hydroxy-3-oxobutanoate = (R)-3-hydroxy-3-methyl-2-oxopentanoate
RHEA:16361	skos:prefLabel	"2-acetolactate mutase"
REACT:R-DRE-70333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KHK dimer phosphorylates Fru to Fru 1-P (Danio rerio)
REACT:R-XTR-9755937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces LAN to 24,25-dhLAN (Xenopus tropicalis)
RHEA:66531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]
REACT:R-MMU-8983063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Mus musculus)
REACT:R-XTR-8865107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MICAL1 produces NADP+, H2O2 (Xenopus tropicalis)
RHEA:54811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 <=> H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)
RHEA:29970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine(in) + H(+)(in) <=> 2'-deoxyuridine(out) + H(+)(out)
RHEA:64345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)
GO:0034853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,4-trimethyl-3-oxopentanoate decarboxylase activity
REACT:R-HSA-4546385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO2 (Homo sapiens)
REACT:R-HSA-8950218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Moesin (Homo sapiens)
REACT:R-DDI-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Dictyostelium discoideum)
RHEA:63913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-azauridine + ATP => 6-azauridine 5'-phosphate + ADP + H(+)
RHEA:18133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate
RHEA:18133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfate adenylyltransferase"
RHEA:18133	skos:altLabel	"sulfate adenylate transferase"
RHEA:18133	skos:altLabel	"sulfurylase"
RHEA:18133	skos:altLabel	"ATP-sulfurylase"
RHEA:18133	skos:prefLabel	"sulfate adenylyltransferase"
REACT:R-CEL-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)
GO:0050271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-alkylcysteine lyase activity
GO:0050271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-alkyl-L-cysteine lyase activity
GO:0050271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-alkylcysteinase activity
GO:0050271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)
GO:0050271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-alkyl-L-cysteinase activity
GO:0050271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-alkyl-L-cysteine sulfoxide lyase activity
GO:0050271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylcysteine lyase activity
GO:0050271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity
GO:0050271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH4(+) + pyruvate
GO:0050271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkyl cysteine lyase activity
RHEA:23435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-6786092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4:IL4R:JAK2 binds IL2RG:JAK3 (Sus scrofa)
GO:0005229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular calcium activated chloride channel activity
GO:0047623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine-phosphate aminohydrolase activity
GO:0047623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenine nucleotide deaminase activity
GO:0047623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine (phosphate) deaminase activity
GO:0047623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine-phosphate deaminase activity
REACT:R-CFA-382061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular processing of novel PDGFs (Canis familiaris)
RHEA:27664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H2O2 => (S)-2-hydroxyglutarate + O2
REACT:R-XTR-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Xenopus tropicalis)
REACT:R-XTR-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)
REACT:R-BTA-3249390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)
RHEA:57079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate 4-phosphate + H2O <=> (2R)-3-phosphoglycerate + glycolate + H(+)
REACT:R-HSA-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Homo sapiens)
REACT:R-CFA-1236958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of particulate antigens with dendritic cell receptors (Canis familiaris)
REACT:R-MMU-192422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular PTL:colipase (Mus musculus)
REACT:R-GGA-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Gallus gallus)
RHEA:33292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:59471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted glutathione + H2O <=> an S-substituted L-cysteinylglycine + L-glutamate
REACT:R-GGA-9708557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 binds BACH1:MAFK (Gallus gallus)
RHEA:56254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:22275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-374683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of L1 with Neurocan (Homo sapiens)
REACT:R-DME-209257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription (Drosophila melanogaster)
REACT:R-HSA-8964333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Homo sapiens)
RHEA:30207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]
RHEA:30207	skos:prefLabel	"methylamine dehydrogenase (amicyanin)"
RHEA:30207	skos:altLabel	"primary-amine dehydrogenase"
RHEA:30207	skos:altLabel	"amine dehydrogenase"
RHEA:30207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylamine dehydrogenase (amicyanin)"
RHEA:30207	skos:altLabel	"MADH"
RHEA:30207	skos:altLabel	"methylamine dehydrogenase"
REACT:R-DDI-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Dictyostelium discoideum)
REACT:R-HSA-893597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial] (Homo sapiens)
RHEA:59420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylamine + O2 = formaldehyde + H2O2 + NH4(+)
REACT:R-CFA-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Canis familiaris)
RHEA:27939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-D-aspartate => glycine + glyoxylate
RHEA:43159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine
REACT:R-DRE-1614605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is dioxygenated (Danio rerio)
RHEA:69322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose => glucoerucin + H2O
REACT:R-BTA-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Bos taurus)
REACT:R-SSC-198941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCAM1 binds Integrin alpha4beta1 (Sus scrofa)
RHEA:72406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + urate(in) <=> 2-oxoglutarate(in) + urate(out)
RHEA:55325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + hexadecanoyl-CoA => 11-cis-retinyl hexadecanoate + CoA
REACT:R-CEL-1878002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLTs transfer Xyl to core protein (Caenorhabditis elegans)
RHEA:36816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-fucose => dTDP-alpha-D-fucofuranose
RHEA:11323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-beta-L-arabinopyranose <=> UDP-alpha-D-xylose
REACT:R-BTA-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
RHEA:61905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone A + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin II
REACT:R-DRE-6810594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Danio rerio)
REACT:R-HSA-265545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1-mediated phytosterol uptake (Homo sapiens)
REACT:R-MMU-4615872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO1 (Mus musculus)
RHEA:30754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexadecanoate <=> AMP + diphosphate + hexadecanoyl-CoA
RHEA:34815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 NADP(+) + tetrahydrocurcumin = curcumin + 2 H(+) + 2 NADPH
RHEA:50340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone = 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0032564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP binding
RHEA:15192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c553] + formate <=> CO2 + 2 Fe(II)-[cytochrome c553] + H(+)
RHEA:72468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 6 CO2 + 8 CoA + H2O + o-orsellinate depside
REACT:R-SSC-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Sus scrofa)
RHEA:15083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ADP + phosphate => acetate + ATP + CoA
RHEA:40658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate + succinyl-CoA <=> (R)-malyl-CoA + succinate
REACT:R-HSA-73758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Homo sapiens)
RHEA:57898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2
REACT:R-BTA-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Bos taurus)
RHEA:50073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + tauroursodeoxycholate(in) => ADP + H(+) + phosphate + tauroursodeoxycholate(out)
RHEA:33045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-6-exo-hydroxycamphor + H2O + NADP(+) => (1R,4R)-camphor + H(+) + NADPH + O2
REACT:R-SCE-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Saccharomyces cerevisiae)
RHEA:28322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + wogonin = UDP + wogonin 7-O-beta-D-glucuronate
GO:0035613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA stem-loop binding
GO:0035613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA hairpin binding
GO:0035613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA hairpin loop binding
REACT:R-MMU-9706308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRB10 (Mus musculus)
REACT:R-BTA-1236964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of peptide bound MHC class I complex to cell surface (Bos taurus)
RHEA:12509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loganate + S-adenosyl-L-methionine => loganin + S-adenosyl-L-homocysteine
REACT:R-BTA-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Bos taurus)
GO:0043727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-4-imidazole carboxylate lyase activity
REACT:R-RNO-1605723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Rattus norvegicus)
RHEA:12511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loganate + S-adenosyl-L-methionine <=> loganin + S-adenosyl-L-homocysteine
REACT:R-HSA-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Homo sapiens)
REACT:R-CEL-209973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is diiodinated (Caenorhabditis elegans)
REACT:R-HSA-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Homo sapiens)
REACT:R-SSC-9709454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR binds EPOR agonists (Sus scrofa)
GO:0047267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity
GO:0047267	skos:prefLabel	"undecaprenyl-phosphate mannosyltransferase"
GO:0047267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"undecaprenyl-phosphate mannosyltransferase"
GO:0047267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity
GO:0047267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-D-mannose:lipid phosphate transmannosylase activity
GO:0047267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyl-phosphate mannosyltransferase activity
GO:0047267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP mannose-undecaprenyl phosphate mannosyltransferase activity
REACT:R-RNO-4086392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)
REACT:R-CFA-983194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-1 is a heterotetramer (Canis familiaris)
GO:0047942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	theanine synthetase activity
GO:0047942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(5)-ethyl-L-glutamine synthetase activity
GO:0047942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-ethylamine ligase activity
GO:0047942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:ethylamine ligase (ADP-forming)
GO:0047942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-ethylglutamine synthetase activity
GO:0047942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-ethyl-L-glutamine synthetase activity
RHEA:23087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 7-methyl-3-oxooct-6-enoyl-CoA + acetate
REACT:R-HSA-4332390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation and activation of PKC alpha in response to WNT signaling (Homo sapiens)
REACT:R-DME-170843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 phosphorylates TGFBR1 (Drosophila melanogaster)
REACT:R-HSA-9023461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 T158A:SIN3A complex does not bind BDNF gene promoter (Homo sapiens)
RHEA:31458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + reduced riboflavin <=> 2 H(+) + NADH + riboflavin
GO:0140943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K20 trimethyltransferase activity
GO:0140943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-trimethyltransferase activity (H4-K20 specific)
GO:0140943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K20 trimethylase activity
GO:0140943	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H4K20 trimethylation
GO:0140943	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H4-K20 trimethylation
REACT:R-MMU-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Mus musculus)
REACT:R-HSA-9631296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the FABP6 gene (Homo sapiens)
REACT:R-SSC-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Sus scrofa)
REACT:R-XTR-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Xenopus tropicalis)
RHEA:47429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) => 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH
RHEA:72661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxyquinoline N-oxide + H2O + NADP(+) => NADPH + O2 + quinolin-8-ol
REACT:R-MMU-177157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Mus musculus)
REACT:R-XTR-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Xenopus tropicalis)
REACT:R-GGA-9689680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNG inhibitors (Gallus gallus)
RHEA:69232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hydroxypropyl glucosinolate + H2O = (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
REACT:R-RNO-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Rattus norvegicus)
REACT:R-SSC-211191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF with alpha:beta importin (Sus scrofa)
REACT:R-MMU-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Mus musculus)
REACT:R-HSA-9669859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Imatinib-resistant KIT mutants do not bind imatinib (Homo sapiens)
REACT:R-SSC-947673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanin-concentrating hormone receptors bind MCH (Sus scrofa)
REACT:R-MMU-211966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2D6 4-hydroxylates debrisoquine (Mus musculus)
RHEA:31434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-beta-santalene + diphosphate
GO:0090583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity
RHEA:67925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate => 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP
RHEA:69982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol
RHEA:24480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-primeverosidase"
RHEA:24480	skos:prefLabel	"beta-primeverosidase"
GO:0034569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monodemethylisoproturon dehydrogenase activity
RHEA:36882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O
REACT:R-SPO-5672329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CLIP1 and microtubules (Schizosaccharomyces pombe)
REACT:R-RNO-2129375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin cross-linking by lysyl oxidase (Rattus norvegicus)
REACT:R-BTA-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Bos taurus)
RHEA:20768	skos:prefLabel	"phosphonopyruvate decarboxylase"
RHEA:20768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphonopyruvate decarboxylase"
RHEA:20768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphonopyruvate + H(+) = CO2 + phosphonoacetaldehyde
RHEA:20768	skos:altLabel	"3-phosphonopyruvate carboxy-lyase"
REACT:R-BTA-8874979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD3 binds GOLGB1 (Bos taurus)
REACT:R-BTA-450257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
RHEA:51020	skos:prefLabel	"alcohol dehydrogenase (cytochrome c)"
RHEA:51020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol dehydrogenase (cytochrome c)"
RHEA:51020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + 2 Fe(III)-[cytochrome c] = an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-DDI-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Dictyostelium discoideum)
REACT:R-DRE-917987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFRC dimer binds 2xholoTF (Danio rerio)
RHEA:62988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanamide + H2O = dodecanoate + NH4(+)
RHEA:47717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pregnen-20,21-diol-3-one + NAD(+) => 21-hydroxyprogesterone + H(+) + NADH
RHEA:46296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Dictyostelium discoideum)
REACT:R-BTA-8948224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)
RHEA:47627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CoA:NAD(P)+ oxidoreductase activity
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-disulfide reductase (NADH) activity
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme A disulfide reductase activity
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-disulphide reductase activity
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2:CoA-disulfide oxidoreductase activity
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CoA-disulfide reductase (NAD(P)H) activity
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CoA:NAD+ oxidoreductase activity
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CoADR activity
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-disulfide reductase activity
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CoA-disulfide reductase (NADH2)
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CoA-disulfide reductase [NAD(P)H]
GO:0050451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:CoA-disulfide oxidoreductase activity
RHEA:15952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxooctadecanoate + H(+) + NADH
REACT:R-CEL-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Caenorhabditis elegans)
RHEA:28239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calycosin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin
RHEA:41005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O
GO:0030370	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intercellular adhesion molecule-3 receptor ligand
GO:0030370	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ICAM-3 receptor ligand
GO:0030370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICAM-3 receptor binding
GO:0030370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intercellular adhesion molecule-3 receptor binding
RHEA:65512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 = 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2
REACT:R-BTA-2046096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Bos taurus)
REACT:R-RNO-8853444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PHLDA1 (Rattus norvegicus)
REACT:R-RNO-8869580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEK binds TFAP2A homodimers (Rattus norvegicus)
REACT:R-CFA-3791319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NID1 degradation by MMP19 (Canis familiaris)
REACT:R-HSA-9664991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)
REACT:R-HSA-5654673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Homo sapiens)
RHEA:49420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + valienone = ADP + H(+) + valienone 7-phosphate
RHEA:54173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) => 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:34160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + UDP-N-acetylbacillosamine => CoA + H(+) + UDP-N,N'-diacetylbacillosamine
REACT:R-HSA-210300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and TREM2 (Homo sapiens)
RHEA:58258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + L-seryl-[protein] => H2O + O-(ADP-D-ribosyl)-L-seryl-[protein]
REACT:R-MMU-392187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated P2Y purinoceptor 12 binds G-protein Gi (Mus musculus)
RHEA:49240	skos:prefLabel	"protein-N(pi)-phosphohistidine--N-acetyl-D-glucosamine phosphotransferase"
RHEA:49240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--N-acetyl-D-glucosamine phosphotransferase"
RHEA:49240	skos:altLabel	"N-acetyl-D-glucosamine PTS permease"
RHEA:49240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)
REACT:R-CFA-422051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the signal peptide of Preproghrelin (Canis familiaris)
REACT:R-DDI-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Dictyostelium discoideum)
RHEA:57251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP <=> dGTP + glycolate + H(+)
RHEA:41375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:12231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-aspartate + L-glutamine <=> AMP + diphosphate + H(+) + L-asparagine + L-glutamate
REACT:R-SSC-1614654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Sus scrofa)
RHEA:20908	skos:altLabel	"N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase"
RHEA:20908	skos:altLabel	"heparan glucuronyltransferase II"
RHEA:20908	skos:prefLabel	"N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase"
RHEA:20908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase"
RHEA:20908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP
RHEA:37807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
GO:0050057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose = H(+) + linamarin + UDP
GO:0050057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity
GO:0050057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linamarin synthase"
GO:0050057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity
GO:0050057	skos:prefLabel	"linamarin synthase"
GO:0050057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity
GO:0050057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity
GO:0050057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucose ketone cyanohydrin glucosyltransferase activity
GO:0050057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linamarin synthase activity
GO:0050057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity
GO:0050057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-ketone glucosyltransferase activity
REACT:R-CFA-9610154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated MAP2Ks and MAPKs (Canis familiaris)
REACT:R-DDI-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Dictyostelium discoideum)
RHEA:63039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanamide <=> NH4(+) + octadecanoate
GO:0050409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity
GO:0050409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indolylacetylinositol arabinosyltransferase activity
GO:0050409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arabinosylindolylacetylinositol synthase activity
GO:0050409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity
RHEA:18656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	barbiturate + H2O <=> 3-oxo-3-ureidopropanoate
RHEA:63828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + vanillin = pyruvate + vanillylamine
RHEA:63828	skos:prefLabel	"vanillin aminotransferase"
RHEA:63828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vanillin aminotransferase"
RHEA:71434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)
REACT:R-RNO-8863973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of ERC and phagosome (Rattus norvegicus)
RHEA:57077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate 4-phosphate + H2O => (2R)-3-phosphoglycerate + glycolate + H(+)
REACT:R-DDI-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Dictyostelium discoideum)
RHEA:68117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol => a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol
REACT:R-BTA-5668735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX3 complex (Bos taurus)
REACT:R-RNO-451561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO binds polyubiquitinated IRAK1 (Rattus norvegicus)
REACT:R-GGA-9625487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates downstream of EGFR (Gallus gallus)
REACT:R-XTR-68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated geminin is degraded by the proteasome (Xenopus tropicalis)
RHEA:27526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate
RHEA:27526	skos:prefLabel	"farnesyl diphosphatase"
RHEA:27526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"farnesyl diphosphatase"
RHEA:27526	skos:altLabel	"FPP phosphatase"
REACT:R-XTR-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Xenopus tropicalis)
RHEA:29009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Mn(2+)(out) => H(+)(in) + Mn(2+)(in)
REACT:R-BTA-5635868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-GLI is degraded by the proteasome (Bos taurus)
REACT:R-GGA-8986985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Gallus gallus)
RHEA:48783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-erythrulose <=> ADP + H(+) + L-erythrulose 1-phosphate
RHEA:63314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2
GO:0050162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalic acid oxidase activity
GO:0050162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate oxidase activity
GO:0050162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalate:oxygen oxidoreductase activity
GO:0050162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aero-oxalo dehydrogenase activity
REACT:R-DRE-430158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds VAV (Danio rerio)
REACT:R-GGA-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Gallus gallus)
REACT:R-CFA-5675948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFRSF6B binds TNFSF6,14,15 (Canis familiaris)
RHEA:35258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + lipid A-core(in) <=> ADP + H(+) + lipid A-core(out) + phosphate
GO:0031733	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR8 chemokine receptor ligand
GO:0031733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR8 chemokine receptor binding
GO:0106371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluorescent chlorophyll catabolite monooxygenase (deformylase) activity
GO:0106371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite
REACT:R-HSA-1989749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ACOX1 (Homo sapiens)
REACT:R-SCE-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Saccharomyces cerevisiae)
RHEA:31789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate
REACT:R-HSA-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Homo sapiens)
RHEA:47732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-109278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Canis familiaris)
GO:0004054	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine 5'-triphosphate-arginine phosphotransferase activity
GO:0004054	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine phosphokinase activity
GO:0004054	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:L-arginine N-phosphotransferase activity
GO:0004054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine kinase activity
GO:0004054	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine 5'-triphosphate:L-arginine
REACT:R-DDI-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Dictyostelium discoideum)
GO:0032450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltase activity
GO:0032450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose alpha-glucosidase activity
REACT:R-BTA-8863804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)
REACT:R-MMU-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Mus musculus)
REACT:R-SCE-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Saccharomyces cerevisiae)
RHEA:61980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + ubiquinone-10 = NADP(+) + ubiquinol-10
REACT:R-DRE-1604741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP14 (MT1-MMP) (Danio rerio)
RHEA:44972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + hexanoyl-CoA = CoA + O-hexanoyl-(R)-carnitine
REACT:R-SSC-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Sus scrofa)
RHEA:46976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2
RHEA:10201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate + NAD(+) => (2E)-2-butenoate + H(+) + NADH
RHEA:16461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + urate(in) = ADP + H(+) + phosphate + urate(out)
RHEA:46126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-391941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLT receptors can bind LTB4 (Danio rerio)
RHEA:57837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + thermospermine => 3-aminopropanal + H2O2 + spermidine
REACT:R-CEL-5649764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)
REACT:R-RNO-2029467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)
REACT:R-CFA-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)
REACT:R-MMU-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Mus musculus)
REACT:R-CFA-8940959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurolysin degrades neurotensin (Canis familiaris)
RHEA:30385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-7-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-BTA-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Bos taurus)
RHEA:61979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]
RHEA:39509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH
GO:0008398	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol 14alpha-demethylase activity
GO:0008398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol 14-demethylase activity
GO:0008398	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lanosterol 14alpha-demethylase activity
GO:0008398	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP51
GO:0008398	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 51 activity
GO:0008398	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lanosterol 14-alpha-demethylase activity
GO:0008398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 demethylates LNSOL (Homo sapiens)
GO:0008398	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	obtusufoliol 14-demethylase activity
GO:0008398	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol 14-alpha-demethylase activity
GO:0008398	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lanosterol 14-demethylase activity
REACT:R-XTR-210282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GPVI and FceRI gamma (Xenopus tropicalis)
RHEA:59807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine <=> D-phenylalanine
REACT:R-DDI-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Dictyostelium discoideum)
RHEA:15362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-alpha-D-xylose => a dolichyl D-xylosyl phosphate + UDP
REACT:R-CFA-5654148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR3 (Canis familiaris)
RHEA:36020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-MMU-5672948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK3 phosphorylates KSR1 (Mus musculus)
REACT:R-RNO-419843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCR (Rattus norvegicus)
REACT:R-XTR-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Xenopus tropicalis)
RHEA:13875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-diene + diphosphate => (+)-copalyl diphosphate
RHEA:63091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9768829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRF stimulates NPAS4 gene transcription (Homo sapiens)
RHEA:23540	skos:altLabel	"glutamyl-tRNA synthetase"
RHEA:23540	skos:altLabel	"glutamic acid translase"
RHEA:23540	skos:prefLabel	"glutamate--tRNA ligase"
RHEA:23540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)
RHEA:23540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate--tRNA ligase"
REACT:R-HSA-5624953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL13B binds INPP5E (Homo sapiens)
REACT:R-DRE-1497853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Danio rerio)
REACT:R-SSC-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Sus scrofa)
RHEA:33223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA
RHEA:17636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucuronoside + H2O <=> an alcohol + D-glucuronate
REACT:R-CFA-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Canis familiaris)
REACT:R-MMU-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Mus musculus)
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NADP(+) = FMN + 2 H(+) + NADPH
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:flavin oxidoreductase activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent FMN reductase activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:FMN oxidoreductase activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	flavine mononucleotide reductase activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH(2):FMN oxidoreductase activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH dehydrogenase (FMN) activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SsuE
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2 dehydrogenase (FMN)
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH(2) dehydrogenase (FMN) activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	flavin mononucleotide reductase activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN reductase (NADPH) activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-FMN reductase activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMNH2:NADP+ oxidoreductase activity
GO:0052873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2:FMN oxidoreductase activity
REACT:R-DRE-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Danio rerio)
RHEA:31991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + sesquithujene
RHEA:31991	skos:prefLabel	"sesquithujene synthase"
RHEA:31991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sesquithujene synthase"
RHEA:31991	skos:altLabel	"TPS5-Del1"
RHEA:42169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH
RHEA:10785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate
REACT:R-XTR-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Xenopus tropicalis)
REACT:R-SSC-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Sus scrofa)
REACT:R-SSC-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Sus scrofa)
RHEA:40260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenedioyl-CoA + H2O => (3S)-hydroxyhexadecanedioyl-CoA
REACT:R-CFA-8981606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin binds oxygen (Canis familiaris)
RHEA:50523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]
REACT:R-BTA-2168923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XVIII endostatin release (Bos taurus)
REACT:R-GGA-9013022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GAPs stimulate RHOB GTPase activity (Gallus gallus)
RHEA:60287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-CFA-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Canis familiaris)
GO:0005537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannose binding lectin
GO:0005537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose binding
GO:0005537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi (Homo sapiens)
REACT:R-HSA-205117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)
RHEA:49878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:31528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-hydroxy-L-arginine => (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O
GO:0033951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharide reducing-end xylanase activity
GO:0033951	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Rex
GO:0033951	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity
GO:0033951	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reducing end xylose-releasing exo-oligoxylanase activity
REACT:R-SCE-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Saccharomyces cerevisiae)
GO:0052922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity
GO:0052922	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(all-E) hexaprenyl diphosphate synthase activity
GO:0052922	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(all-trans)-hexaprenyl-diphosphate synthase activity
GO:0052922	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hexaprenyl pyrophosphate synthetase activity
GO:0052922	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hexaprenyl diphosphate synthase activity
GO:0035381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-gated ion channel activity
RHEA:30366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumonisin B1 + 2 H2O <=> (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate
REACT:R-DME-432381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP1 replaces VRI as binder to Clk and cry genes (Drosophila melanogaster)
REACT:R-MMU-3785684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by CTSG (Mus musculus)
REACT:R-SPO-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Schizosaccharomyces pombe)
GO:0005220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,4,5-trisphosphate receptor activity
GO:0005220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3 receptor activity
GO:0005220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	InsP3 receptor
RHEA:49414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose
REACT:R-GGA-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Gallus gallus)
REACT:R-XTR-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Xenopus tropicalis)
REACT:R-SSC-112437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NELF complex  (Sus scrofa)
RHEA:52617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)
REACT:R-XTR-982792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor binds JAK2 (Xenopus tropicalis)
GO:0061655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
GO:0061655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pup conjugating enzyme activity
REACT:R-RNO-6791221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Rattus norvegicus)
REACT:R-HSA-5663165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds AVP gene (Homo sapiens)
REACT:R-XTR-1250315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB4 homodimers (Xenopus tropicalis)
REACT:R-HSA-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)
RHEA:32074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate
REACT:R-XTR-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Xenopus tropicalis)
REACT:R-HSA-177946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-EGF is cleaved to form mature EGF (Homo sapiens)
RHEA:49456	skos:prefLabel	"trans-2,3-dihydro-3-hydroxyanthranilic acid synthase"
RHEA:49456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-2,3-dihydro-3-hydroxyanthranilic acid synthase"
RHEA:49456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate
RHEA:49456	skos:altLabel	"isochorismatase"
REACT:R-BTA-975916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 5 by MGAT5 (Bos taurus)
REACT:R-SSC-432909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Plectin with Integrin beta 4 (Sus scrofa)
REACT:R-BTA-429571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Bos taurus)
GO:0015054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gastrin receptor activity
GO:0015054	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholecystokinin-B receptor activity
REACT:R-MMU-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Mus musculus)
RHEA:53160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-sn-glycero-3-phosphoethanolamine = an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate
RHEA:43895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-H + L-cysteine <=> [sulfur carrier]-SH + L-alanine
REACT:R-HSA-5654565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Homo sapiens)
RHEA:11922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-6,7-dihydrobiopterin + H2O => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
RHEA:12735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate => CO2 + diphosphate + nicotinate beta-D-ribonucleotide
REACT:R-GGA-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Gallus gallus)
REACT:R-SSC-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Sus scrofa)
REACT:R-GGA-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Gallus gallus)
RHEA:58396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-GGA-9032073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-phosphorylated FRS2 binds GRB2 (Gallus gallus)
REACT:R-CEL-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Caenorhabditis elegans)
REACT:R-SSC-8853774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Sus scrofa)
GO:0008528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide receptor activity, G protein coupled
GO:0008528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide receptor activity, G-protein coupled
GO:0008528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled peptide receptor activity
GO:0008528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled peptide receptor activity
GO:0008528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled peptide receptor activity
RHEA:54210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2
REACT:R-HSA-5210943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)
REACT:R-CEL-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Caenorhabditis elegans)
RHEA:58181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + diphosphate + NADP(+)
REACT:R-DRE-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Danio rerio)
REACT:R-HSA-2029272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of PLCG from FCGR (Homo sapiens)
RHEA:12500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiomorpholine-carboxylate dehydrogenase"
RHEA:12500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH
RHEA:12500	skos:prefLabel	"thiomorpholine-carboxylate dehydrogenase"
RHEA:12500	skos:altLabel	"ketimine reductase"
RHEA:12500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH
RHEA:20663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-alanine => D-alanyl-D-alanine + H2O
GO:0018811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohex-1-ene-1-carboxyl-CoA hydratase activity
REACT:R-BTA-6784189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind LIFR (Bos taurus)
REACT:R-XTR-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Xenopus tropicalis)
RHEA:43486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O
REACT:R-GGA-374173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR1 (Gallus gallus)
REACT:R-SSC-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Sus scrofa)
REACT:R-BTA-6786166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translesion synthesis across unhooked ICL by POLN (Bos taurus)
REACT:R-CEL-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Caenorhabditis elegans)
GO:0019136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ms-dNK activity
GO:0019136	skos:altLabel	"multifunctional deoxynucleoside kinase"
GO:0019136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxynucleoside kinase"
GO:0019136	skos:altLabel	"multisubstrate deoxyribonucleoside kinase"
GO:0019136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Dm-dNK
GO:0019136	skos:altLabel	"multispecific deoxynucleoside kinase"
GO:0019136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxynucleoside kinase activity
GO:0019136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multisubstrate deoxyribonucleoside kinase activity
GO:0019136	skos:prefLabel	"deoxynucleoside kinase"
GO:0019136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multispecific deoxynucleoside kinase activity
GO:0019136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ms-dNK
GO:0019136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D. melanogaster deoxynucleoside kinase activity
GO:0019136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:deoxynucleoside 5'-phosphotransferase activity
GO:0019136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multifunctional deoxynucleoside kinase activity
GO:0019136	skos:altLabel	"ms-dNK"
REACT:R-BTA-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Bos taurus)
RHEA:41546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine
GO:0008431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tocopherol binding
GO:0008431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin E binding
GO:0008431	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-tocopherol binding
REACT:R-MMU-1462023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-pro-defensins are cleaved to remove the signal peptide (Mus musculus)
REACT:R-HSA-9694495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTC binds SARS-CoV-2 genomic RNA complement (minus strand) (Homo sapiens)
REACT:R-DME-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Drosophila melanogaster)
RHEA:49306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O
RHEA:34644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + squalene => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:33969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-maleylpyruvate + H(+) => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O
REACT:R-HSA-159046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)
REACT:R-XTR-8874470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Xenopus tropicalis)
REACT:R-CFA-9707594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind LY96 (Canis familiaris)
REACT:R-GGA-5654397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS2 (Gallus gallus)
REACT:R-DRE-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Danio rerio)
RHEA:44380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:71216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + thiocyanate(out) => 2 Na(+)(in) + thiocyanate(in)
RHEA:37233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + NH4(+) => H2O + L-alaninamide
REACT:R-BTA-1022133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Bos taurus)
REACT:R-XTR-9018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds interacting proteins at the endosome membrane (Xenopus tropicalis)
GO:0032934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol carrier activity
GO:0032934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol binding
RHEA:72220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 hydrogencarbonate(out) + Na(+)(out) => 3 hydrogencarbonate(in) + Na(+)(in)
RHEA:10870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + CoA => a 1,2-diacyl-sn-glycerol + an acyl-CoA
RHEA:29187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate + ubiquinone-8 = fumarate + ubiquinol-8
RHEA:35050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-molybdopterin + H(+) + molybdate <=> AMP + H2O + Mo-molybdopterin
REACT:R-DRE-9686524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6-PPP6R3 dephosphorylates TERF2 (Danio rerio)
REACT:R-DDI-5689000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Dictyostelium discoideum)
REACT:R-DDI-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Dictyostelium discoideum)
REACT:R-CFA-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)
RHEA:13375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4H-pyrid-4-one + L-serine => H2O + L-mimosine
RHEA:47328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)
RHEA:66249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + IC-asc-C9-AMP => AMP + H(+) + IC-asc-C9-CoA
RHEA:29731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-maltose(in) = beta-maltose(out)
REACT:R-DRE-1483002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to 1-acyl GO3P by GNPAT (Danio rerio)
RHEA:13329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxosteroid = a 3-oxo-Delta(1)-steroid + AH2
RHEA:34960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) => (R)-carnitine(out)
RHEA:39664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:56949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + UTP => H(+) + phosphoenolpyruvate + UDP
RHEA:40060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H2O => CoA + decanoate + H(+)
REACT:R-XTR-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Xenopus tropicalis)
REACT:R-HSA-6791035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of NS1 homodimer (Homo sapiens)
REACT:R-SCE-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Saccharomyces cerevisiae)
REACT:R-RNO-5671772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T38-PPP1R14A binds MLCP (Rattus norvegicus)
RHEA:26136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty acid amide hydrolase"
RHEA:26136	skos:prefLabel	"fatty acid amide hydrolase"
RHEA:26136	skos:altLabel	"oleamide hydrolase"
RHEA:26136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)
RHEA:26136	skos:altLabel	"anandamide amidohydrolase"
RHEA:26136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine
REACT:R-DRE-3134883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin enhances association of IRF3 with CBP/p300  (Danio rerio)
RHEA:68079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP <=> a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP
REACT:R-GGA-9018785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds GTP (Gallus gallus)
REACT:R-HSA-5687081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 is ubiquitinated at the N-terminal (Homo sapiens)
REACT:R-SSC-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Sus scrofa)
RHEA:46903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)
REACT:R-CEL-4827383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)
REACT:R-GGA-5218643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90AA1 binds p-6Y-VEGFR2 (Gallus gallus)
REACT:R-MMU-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Mus musculus)
REACT:R-HSA-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Homo sapiens)
REACT:R-CFA-5226964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKH transports PPi from cytosol to extracellular region (Canis familiaris)
RHEA:70944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(in) => L-isoleucine(out)
RHEA:32631	skos:prefLabel	"erythromycin 12 hydroxylase"
RHEA:32631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"erythromycin 12 hydroxylase"
RHEA:32631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin D + H(+) + NADPH + O2 = erythromycin C + H2O + NADP(+)
REACT:R-BTA-5668718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)
REACT:R-XTR-1889978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALT6 transfers Gal to the tetrasaccharide linker (Xenopus tropicalis)
REACT:R-BTA-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)
GO:0080084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S rDNA binding
REACT:R-MMU-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)
REACT:R-BTA-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Bos taurus)
GO:0036106	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEX19-independent mPTS binding
GO:0036106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	class 2 mPTS binding
GO:0036106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisome membrane class-2 targeting sequence binding
REACT:R-BTA-2730851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Bos taurus)
REACT:R-RNO-6809720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM1:MTMR12 (Rattus norvegicus)
REACT:R-MMU-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Mus musculus)
REACT:R-XTR-168848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAK protein (Xenopus tropicalis)
REACT:R-HSA-2730595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT3 Forms Dimers (Homo sapiens)
RHEA:25447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (1E,4E)-germacrene B + diphosphate
REACT:R-CFA-6804955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDM2 (Canis familiaris)
GO:0050399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthommatin reductase activity
GO:0050399	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,12-dihydroxanthommatin:NAD+ oxidoreductase activity
RHEA:22869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-L-alanine + thioglycolate => chloride + H(+) + S-carboxymethyl-L-cysteine
GO:0033701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine-diphosphate-galactose dehydrogenase activity
GO:0033701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-D-galactose:NADP+ 6-oxidoreductase activity
GO:0033701	skos:prefLabel	"dTDP-galactose 6-dehydrogenase"
GO:0033701	skos:altLabel	"thymidine-diphosphate-galactose dehydrogenase"
GO:0033701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDPgalactose 6-dehydrogenase activity
GO:0033701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-D-galactose + H2O + 2 NADP(+) = dTDP-D-galacturonate + 3 H(+) + 2 NADPH
GO:0033701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-galactose 6-dehydrogenase"
GO:0033701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-galactose 6-dehydrogenase activity
REACT:R-HSA-199050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Homo sapiens)
RHEA:52030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonate + an L-alpha-amino acid => a jasmonyl-L-amino acid + H2O
RHEA:39446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)
RHEA:44078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + pentadecanoyl-CoA => ATP + CoA + pentadecanoate
RHEA:49718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+) => 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2
RHEA:58730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine => adenosine in rRNA + S-adenosyl-L-methionine
REACT:R-HSA-912467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 is recruited to unsynapsed regions (Homo sapiens)
REACT:R-SSC-9632033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GalNAc to chondroitin (Sus scrofa)
REACT:R-SSC-8858428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FCAMR binds IgA (Sus scrofa)
REACT:R-CFA-8985929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Canis familiaris)
REACT:R-DRE-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
REACT:R-HSA-381707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)
REACT:R-SSC-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Sus scrofa)
REACT:R-DRE-9678935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Danio rerio)
RHEA:72242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + L-glutamate(in) <=> estrone 3-sulfate(in) + L-glutamate(out)
RHEA:12230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-asparagine + L-glutamate => ATP + H2O + L-aspartate + L-glutamine
RHEA:58872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:24590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-arabinose 5-phosphate + H(+) => ATP + D-arabinose
RHEA:14025	skos:prefLabel	"sepiapterin deaminase"
RHEA:14025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sepiapterin deaminase"
RHEA:14025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + sepiapterin = NH4(+) + xanthopterin-B2
RHEA:67544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine
REACT:R-SSC-70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Sus scrofa)
RHEA:45697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(acetyl)-sphing-4-enine-1-phosphate(in) => N-(acetyl)-sphing-4-enine-1-phosphate(out)
RHEA:32520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + S-adenosyl-L-methionine => (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine
GO:0061657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UFM1 conjugating enzyme activity
GO:0061657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
REACT:R-SSC-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Sus scrofa)
REACT:R-SSC-2512800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1:ligand is endocytosed (Sus scrofa)
REACT:R-GGA-9011748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R binds JAK1 (Gallus gallus)
EC:2.3.1.48	skos:altLabel	"protein lysine acetyltransferase"
EC:2.3.1.48	skos:altLabel	"lysine acetyltransferase"
EC:2.3.1.48	skos:prefLabel	"histone acetyltransferase"
EC:2.3.1.48	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histone acetyltransferase"
REACT:R-HSA-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Homo sapiens)
GO:0047706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biochanin-A reductase activity
GO:0047706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity
RHEA:14108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NAD(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADH
REACT:R-HSA-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Homo sapiens)
REACT:R-DME-8864595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2B homodimer binds YEATS4 (Drosophila melanogaster)
RHEA:13444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteate <=> H(+) + NH4(+) + pyruvate + sulfite
RHEA:47604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) = CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)
REACT:R-HSA-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
REACT:R-HSA-975857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)
RHEA:45785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + phenylpropanonitrile => 3-phenylpropanoate + NH4(+)
REACT:R-BTA-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Bos taurus)
REACT:R-BTA-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Bos taurus)
REACT:R-MMU-73596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => dUMP + NH4+ (Mus musculus)
REACT:R-SSC-3371554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 acetylation at Lys80 (Sus scrofa)
RHEA:35633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-beta-D-galactoside + H(+) + UDP => cyanidin + UDP-alpha-D-galactose
RHEA:44742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + rifamycin SV + S-adenosyl-L-homocysteine => 27-O-demethylrifamycin SV + S-adenosyl-L-methionine
REACT:R-RNO-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Rattus norvegicus)
REACT:R-BTA-6803875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds CDK1 and CCNB1 (Bos taurus)
RHEA:37229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-1,3-pentadiene + CO2 => (E,E)-sorbate + H(+)
RHEA:49953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10aS)-10,10a-dihydrophenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate
REACT:R-HSA-6788346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of IL13-upregulated plasma membrane proteins (Homo sapiens)
RHEA:60648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine
REACT:R-XTR-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Xenopus tropicalis)
REACT:R-MMU-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Mus musculus)
GO:0003914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA (6-4) photolyase activity
RHEA:15834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelate + H(+) + O2 => 4-hydroxybenzaldehyde + CO2 + H2O2
REACT:R-MMU-5676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD74 binds MIF (Mus musculus)
REACT:R-RNO-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Rattus norvegicus)
REACT:R-HSA-4755494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Homo sapiens)
REACT:R-HSA-4341048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RXRA with SUMO1 (Homo sapiens)
RHEA:15944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-acetyl-L-ornithine <=> acetate + L-ornithine
REACT:R-DRE-5228521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Danio rerio)
REACT:R-HSA-1989746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CYP7A1 (Homo sapiens)
REACT:R-MMU-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Mus musculus)
REACT:R-SSC-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Sus scrofa)
REACT:R-DME-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)
RHEA:37966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NAD(+) <=> D-galactose + H(+) + NADH
REACT:R-SPO-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Schizosaccharomyces pombe)
REACT:R-HSA-430076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)
REACT:R-SCE-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Saccharomyces cerevisiae)
REACT:R-MMU-9012268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)
RHEA:66048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate
RHEA:33500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prephenate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2
REACT:R-CFA-8849881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM2 associate with AMPA and NMDA receptors (Canis familiaris)
REACT:R-HSA-2396079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds Plasminogen activator inhibitor- 1 (Homo sapiens)
REACT:R-DME-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Drosophila melanogaster)
RHEA:27627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + D-xylulose 5-phosphate => beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate
RHEA:56071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP
REACT:R-DME-174174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Drosophila melanogaster)
REACT:R-XTR-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)
RHEA:32525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 1-phosphate + D-glucose => nigerose + phosphate
REACT:R-DME-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Drosophila melanogaster)
REACT:R-MMU-9757686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDL (Mus musculus)
RHEA:49146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose
RHEA:51166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine
REACT:R-CEL-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
REACT:R-MMU-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Mus musculus)
RHEA:11391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11beta-hydroxysteroid + NADP(+) <=> an 11-oxosteroid + H(+) + NADPH
RHEA:52205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)
RHEA:63984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine + ATP = 5-hydroxyuridine 5'-phosphate + ADP + H(+)
REACT:R-SSC-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Sus scrofa)
REACT:R-XTR-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Xenopus tropicalis)
RHEA:34617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogencarbonate + methylphosphonate => 2-hydroxyethylphosphonate + O2
RHEA:44914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH
REACT:R-DME-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Drosophila melanogaster)
RHEA:61540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:31668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
RHEA:27930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)
RHEA:27930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-phosphopantoate--beta-alanine ligase"
RHEA:27930	skos:prefLabel	"4-phosphopantoate--beta-alanine ligase"
RHEA:27930	skos:altLabel	"phosphopantothenate synthetase"
RHEA:37726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-MMU-5666216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds TAX1BP3 (Mus musculus)
RHEA:57304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP = glycolate + GMP + H(+)
RHEA:68406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoheptanedioate + CO2 + NADH => (2R,3S)-iso(homo)2citrate + NAD(+)
REACT:R-GGA-9629470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Gallus gallus)
REACT:R-BTA-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Bos taurus)
REACT:R-RNO-934604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)
GO:0102896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	colnelenate synthase activity
REACT:R-CFA-2161907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Canis familiaris)
REACT:R-SCE-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Saccharomyces cerevisiae)
REACT:R-CEL-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)
REACT:R-BTA-5624133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3:GTP binds the UNC119B complex (Bos taurus)
REACT:R-HSA-975119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Homo sapiens)
RHEA:46675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldosterone + H(+) + NADPH <=> 5beta-dihydroaldosterone + NADP(+)
RHEA:10561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O => 2,5-dioxopentanoate + NH4(+)
REACT:R-DDI-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)
REACT:R-HSA-9709831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds TBK1 and IRF3 (Homo sapiens)
REACT:R-HSA-9665701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 (Homo sapiens)
REACT:R-XTR-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
REACT:R-CFA-5654404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds SHC1 (Canis familiaris)
RHEA:42274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA => 3-methylbutanoyl-CoA + H(+) + malonyl-[ACP]
RHEA:61587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Xenopus tropicalis)
RHEA:20767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + pyruvate <=> oxaloacetate + propanoyl-CoA
REACT:R-BTA-1676020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Bos taurus)
RHEA:70145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase]
GO:0005199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of cell wall
REACT:R-XTR-177157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)
REACT:R-XTR-190245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1b binds to FGF (Xenopus tropicalis)
RHEA:31459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiazole tautomerase"
RHEA:31459	skos:prefLabel	"thiazole tautomerase"
RHEA:31459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
REACT:R-BTA-158300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Bos taurus)
RHEA:71590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + 2-oxoglutarate(out) <=> (S)-malate(out) + 2-oxoglutarate(in)
REACT:R-MMU-3222093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 binds TP53 and EP300 (Mus musculus)
RHEA:48911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP
REACT:R-DRE-399952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIMK-1 by PAK (Danio rerio)
GO:0015547	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity
GO:0015547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nalidixic acid transmembrane transporter activity
GO:0015547	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nalidixic acid transporter activity
REACT:R-RNO-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Rattus norvegicus)
REACT:R-DRE-173481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Danio rerio)
RHEA:65116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + aculene B + O2 = aculene A + CO2 + H2O + succinate
GO:0008235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloexopeptidase activity
RHEA:69443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) <=> 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH
REACT:R-CFA-1112510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6ST is tyrosine phosphorylated (Canis familiaris)
RHEA:15244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate <=> 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NADPH + O2 <=> H2O + N-hydroxy-L-aspartate + NADP(+)
REACT:R-RNO-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Rattus norvegicus)
REACT:R-DRE-5661117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Danio rerio)
RHEA:47329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)
RHEA:56800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide = cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]
REACT:R-DME-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Drosophila melanogaster)
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aminoadipate-semialdehyde dehydrogenase activity
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminoadipate semialdehyde dehydrogenase activity
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoadipate-semialdehyde dehydrogenase activity
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoadipate semialdehyde dehydrogenase activity
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AAR
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-aminoadipate reductase activity
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-aminoadipate-semialdehyde dehydrogenase activity
GO:0004043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminoadipic semialdehyde dehydrogenase activity
REACT:R-HSA-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Homo sapiens)
RHEA:11372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate--ammonia ligase"
RHEA:11372	skos:prefLabel	"aspartate--ammonia ligase"
RHEA:11372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine
RHEA:11372	skos:altLabel	"asparagine synthetase"
REACT:R-HSA-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Homo sapiens)
REACT:R-BTA-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Bos taurus)
RHEA:18450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + arsenite + H2O => AH2 + arsenate + H(+)
REACT:R-BTA-9700998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 disrupts the BRCA1:BARD1 heterodimer (Bos taurus)
REACT:R-BTA-264678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Bos taurus)
REACT:R-HSA-9733495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral Spike Binds to ACE2 on Uninfected Cell (Homo sapiens)
RHEA:12304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-aminoadipate-semialdehyde dehydrogenase"
RHEA:12304	skos:altLabel	"2-aminoadipate semialdehyde dehydrogenase"
RHEA:12304	skos:altLabel	"alpha-aminoadipate-semialdehyde dehydrogenase"
RHEA:12304	skos:prefLabel	"L-aminoadipate-semialdehyde dehydrogenase"
RHEA:12304	skos:altLabel	"alpha-aminoadipate reductase"
RHEA:12304	skos:altLabel	"aminoadipate semialdehyde dehydrogenase"
RHEA:12304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H2O + NADP(+) = 2 H(+) + L-2-aminoadipate + NADPH
RHEA:12304	skos:altLabel	"2-aminoadipic semialdehyde dehydrogenase"
RHEA:12304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H2O + NAD(+) = 2 H(+) + L-2-aminoadipate + NADH
RHEA:12304	skos:altLabel	"L-alpha-aminoadipate delta-semialdehyde oxidoreductase"
REACT:R-MMU-5621355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Mus musculus)
REACT:R-HSA-5617483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA2 gene is transcribed (Homo sapiens)
REACT:R-DRE-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Danio rerio)
RHEA:61049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lochnericine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]
RHEA:41294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoylsphing-4-enine <=> dodecanoate + sphing-4-enine
RHEA:25475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-himachalene
REACT:R-SSC-5687653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)
RHEA:39636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)
GO:0019825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxygen binding
GO:0019825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P450 activity
GO:0019825	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450
REACT:R-HSA-2730903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of TRAF6 (Homo sapiens)
RHEA:12462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + H2O => (S)-malate
REACT:R-XTR-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Xenopus tropicalis)
REACT:R-GGA-166271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Gallus gallus)
REACT:R-RNO-1297275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD9:Izumo Binding (Rattus norvegicus)
REACT:R-SSC-1251997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ERBB4m80 by gamma-scretase complex (Sus scrofa)
REACT:R-DRE-2408524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Danio rerio)
REACT:R-GGA-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Gallus gallus)
GO:0050785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAGE activity
GO:0050785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGE receptor activity
GO:0050785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	advanced glycation end-product receptor activity
REACT:R-GGA-83650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FasL:Fas binds FADD (Gallus gallus)
REACT:R-HSA-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Homo sapiens)
REACT:R-DDI-5691381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYSM1 deubiquitinates Histone H2A (Dictyostelium discoideum)
REACT:R-MMU-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Mus musculus)
REACT:R-CFA-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Canis familiaris)
REACT:R-MMU-199050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Mus musculus)
RHEA:51907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate
RHEA:17173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathionylspermidine + H2O = glutathione + spermidine
RHEA:17173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathionylspermidine amidase"
RHEA:17173	skos:altLabel	"glutathionylspermidine amidohydrolase (spermidine-forming)"
RHEA:17173	skos:prefLabel	"glutathionylspermidine amidase"
RHEA:17173	skos:altLabel	"GSP amidase"
REACT:R-BTA-5205672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncleaved Pink1 accumulates in damaged mitochondria (Bos taurus)
REACT:R-DRE-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Danio rerio)
RHEA:10462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin C1 => prostaglandin A1
REACT:R-MMU-9027627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Mus musculus)
REACT:R-SSC-9634702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Sus scrofa)
RHEA:17597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + 2 Fe(III)-[cytochrome c] = D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)
RHEA:17597	skos:prefLabel	"mannitol dehydrogenase (cytochrome)"
RHEA:17597	skos:altLabel	"polyol dehydrogenase"
RHEA:17597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannitol dehydrogenase (cytochrome)"
REACT:R-HSA-9010113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAM10:Zn2+ binds TSPANs (Homo sapiens)
REACT:R-SSC-5626699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK4 binds ODF2 in the centriole (Sus scrofa)
GO:0031219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	levanase activity
GO:0031219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	levan hydrolase activity
GO:0031219	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-beta-D-fructan fructanohydrolase activity
RHEA:58062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H(+) + sulfite => 2-sulfinoacetaldehyde + H2O
RHEA:33178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate(in) <=> 4-hydroxyphenylacetate(out)
REACT:R-BTA-964800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuromedin-U receptors bind neuromedins U, S (Bos taurus)
GO:0052681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming] activity
GO:0052681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-bisabolene synthase activity
GO:0052681	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	bisabolene synthase activity
RHEA:11859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
RHEA:64667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)
RHEA:48197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA
RHEA:18934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O
RHEA:54137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(48) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
RHEA:56168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)
REACT:R-HSA-5334164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3B:DNMT3L binds chromatin (Homo sapiens)
RHEA:43009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine => 2-aminoprop-2-enoate + H2O
RHEA:50231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 + resorcinol <=> benzene-1,2,4-triol + FAD + H(+) + H2O
GO:0047168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity
GO:0047168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate O-dihydroxycinnamoyltransferase activity
REACT:R-DME-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)
RHEA:45159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoyl-CoA + H2O <=> 3-oxopropanoate + CoA + H(+)
REACT:R-XTR-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Xenopus tropicalis)
RHEA:36125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A20 methyl ester + S-adenosyl-L-homocysteine => gibberellin A20 + S-adenosyl-L-methionine
RHEA:39536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O
RHEA:25022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + riboflavin => CDP + FMN + H(+)
RHEA:43835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
REACT:R-DDI-1676149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)
RHEA:50432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + prostaglandin G1 = A + H2O + prostaglandin H1
REACT:R-GGA-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
RHEA:61696	skos:prefLabel	"glyine--[glycyl-carrier protein] ligase"
RHEA:61696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + holo-[peptidyl-carrier protein] = AMP + diphosphate + glycyl-[peptidyl-carrier protein]
RHEA:61696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyine--[glycyl-carrier protein] ligase"
RHEA:62373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)
RHEA:21429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate => H(+) + pyruvate + sulfite
RHEA:38655	skos:prefLabel	"tuliposide B-converting enzyme"
RHEA:38655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tuliposide B-converting enzyme"
RHEA:38655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-tuliposide B = D-glucose + tulipalin B
REACT:R-CFA-158925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Canis familiaris)
RHEA:53426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + CoA + H(+) => a fatty acyl-CoA + a sphingoid base
REACT:R-HSA-2730833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
RHEA:21575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methyl-1H-quinolin-4-one + O2 <=> CO + H(+) + N-acetylanthranilate
RHEA:28085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ethylmalonyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + CO2 + NADPH
RHEA:45285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + sphing-4-enine => CoA + H(+) + N-eicosanoyl-sphing-4-enine
REACT:R-MMU-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Mus musculus)
RHEA:54834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:51724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-tetraphosphate + ADP + 2 H(+)
REACT:R-MMU-9718394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide antagonists (Mus musculus)
REACT:R-DRE-416559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)
REACT:R-RNO-9634846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNTL (BMAL1) (Rattus norvegicus)
RHEA:14077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-alanine--pyruvate transaminase"
RHEA:14077	skos:altLabel	"Omega-amino acid--pyruvate aminotransferase"
RHEA:14077	skos:prefLabel	"beta-alanine--pyruvate transaminase"
RHEA:14077	skos:altLabel	"beta-alanine--pyruvate aminotransferase"
RHEA:14077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + L-alanine = beta-alanine + pyruvate
REACT:R-MMU-5694126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C3B hydrolyses 7MGP to 7MG (Mus musculus)
RHEA:64125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-L-phenylalanine => hexadecanoate + L-phenylalanine
REACT:R-DRE-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Danio rerio)
REACT:R-SCE-199839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate RSK (Saccharomyces cerevisiae)
GO:0003886	skos:altLabel	"DNA-cytosine 5-methylase"
GO:0003886	skos:altLabel	"DNA-cytosine methyltransferase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytosine-specific DNA methyltransferase activity
GO:0003886	skos:altLabel	"DNA methylase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA-cytosine methyltransferase activity
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-cytosine 5-methylase activity
GO:0003886	skos:altLabel	"deoxyribonucleic acid modification methylase"
GO:0003886	skos:altLabel	"cytosine DNA methylase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleic methylase activity
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA cytosine C5 methylase activity
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytosine DNA methylase activity
GO:0003886	skos:altLabel	"cytosine 5-methyltransferase"
GO:0003886	skos:altLabel	"deoxyribonucleic (cytosine-5-)-methyltransferase"
GO:0003886	skos:altLabel	"deoxyribonucleic acid methylase"
GO:0003886	skos:altLabel	"modification methylase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA 5-cytosine methylase activity
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA (cytosine-5-)-methyltransferase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
GO:0003886	skos:altLabel	"DNA methyltransferase"
GO:0003886	skos:altLabel	"site-specific DNA-methyltransferase (cytosine-specific)"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytosine DNA methyltransferase activity
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic acid (cytosine-5-)-methyltransferase activity
GO:0003886	skos:prefLabel	"DNA (cytosine-5-)-methyltransferase"
GO:0003886	skos:altLabel	"deoxyribonucleic acid methyltransferase"
GO:0003886	skos:altLabel	"DNA 5-cytosine methylase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA (cytosine-5-)-methyltransferase activity
GO:0003886	skos:altLabel	"deoxyribonucleic acid (cytosine-5-)-methyltransferase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytosine 5-methyltransferase activity
GO:0003886	skos:altLabel	"Type II DNA methylase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylphosphotriester-DNA methyltransferase activity
GO:0003886	skos:altLabel	"deoxyribonucleate methyltransferase"
GO:0003886	skos:altLabel	"deoxyribonucleate methylase"
GO:0003886	skos:altLabel	"DNA transmethylase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA cytosine methylase activity
GO:0003886	skos:altLabel	"DNA cytosine C(5) methylase"
GO:0003886	skos:altLabel	"methylphosphotriester-DNA methyltransferase"
GO:0003886	skos:altLabel	"deoxyribonucleic methylase"
GO:0003886	skos:altLabel	"cytosine DNA methyltransferase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	site-specific DNA-methyltransferase (cytosine-specific) activity
GO:0003886	skos:altLabel	"DNA cytosine methylase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	restriction-modification system activity
GO:0003886	skos:altLabel	"cytosine-specific DNA methyltransferase"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic (cytosine-5-)-methyltransferase activity
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	modification methylase activity
GO:0003886	skos:altLabel	"restriction-modification system"
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II DNA methylase activity
GO:0003886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA cytosine C(5) methylase activity
GO:0047346	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ADP-sugar phosphorylase activity
GO:0047346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphate glucose:orthophosphate adenylyltransferase activity
GO:0047346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADPaldose phosphorylase activity
GO:0047346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldose-1-phosphate adenylyltransferase activity
GO:0047346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP:aldose-1-phosphate adenylyltransferase activity
GO:0047346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphosugar phosphorylase activity
GO:0047346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-aldose phosphorylase activity
GO:0047346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity
GO:0047346	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sugar-1-phosphate adenylyltransferase activity
GO:0047346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP sugar phosphorylase activity
REACT:R-DDI-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)
GO:0043793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-RFAP synthase activity
GO:0043793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ribofuranosylaminobenzene 5'-phosphate synthase activity
REACT:R-BTA-5668984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 or PAK2 phosphorylates MYLK (Bos taurus)
REACT:R-HSA-9716258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimethyl fumarate modifies Cys191 in GSDMD (Homo sapiens)
REACT:R-BTA-380272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plk1-mediated phosphorylation of Nlp (Bos taurus)
REACT:R-XTR-211923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)
RHEA:47446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-tetradecenoyl-CoA + acetyl-CoA => 3-oxo-(7Z-hexadecenoyl)-CoA + CoA
RHEA:50517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]
RHEA:52774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate => 7,8-dihydroneopterin 3'-triphosphate
REACT:R-HSA-8868230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
REACT:R-HSA-549060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NrCAM binds Neuropilin-2 (Homo sapiens)
GO:0043816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SepRS
GO:0043816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoserine--tRNA(Cys) ligase activity
GO:0043816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoserine-tRNA(Cys) ligase activity
GO:0043816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoserine-tRNACys ligase activity
GO:0043816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-phosphoseryl-tRNA(Cys) synthetase activity
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylmuramic acid L-alanine amidase activity
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylmuramylalanine amidase activity
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylmuramyl-alanine amidase activity
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acylmuramyl-L-alanine amidase activity
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 hydrolyzes bacterial peptidoglycan (Homo sapiens)
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylmuramoyl-L-alanine amidase activity
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylmuramoyl-L-alanine amidase type I
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylmuramoyl-alanine amidase activity
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylmuramoyl-L-alanine amidase type II
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylmuramyl-L-alanine amidase activity
GO:0008745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylmuramyl-L-alanine amidase activity
RHEA:10784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate
RHEA:15162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)
REACT:R-RNO-8856630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIDEA:CIDEC binds lipid droplets (Rattus norvegicus)
REACT:R-CFA-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Canis familiaris)
REACT:R-RNO-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Rattus norvegicus)
RHEA:71056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(out) + L-methionine(in) => L-cysteine(in) + L-methionine(out)
RHEA:51353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-serine => (9Z)-octadecenoate + L-serine
RHEA:32502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,5R)-sabinene + H(+) + NADPH + O2 <=> (1S,3R,5S)-sabinol + H2O + NADP(+)
REACT:R-SSC-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Sus scrofa)
REACT:R-CFA-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Canis familiaris)
RHEA:59764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-GGA-8981622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin:oxygen dissociates (Gallus gallus)
RHEA:67853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + O2 => FMN-N(5)-peroxide
RHEA:43759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]
GO:0047486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin ABC lyase activity
REACT:R-GGA-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Gallus gallus)
RHEA:62371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(out) + 2 hydrogencarbonate(out) <=> Fe(2+)(in) + 2 hydrogencarbonate(in)
REACT:R-HSA-9665704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)
RHEA:57089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)
GO:0036308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16S rRNA (guanine(1516)-N(2))-methyltransferase activity
REACT:R-SCE-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Saccharomyces cerevisiae)
GO:0008392	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2J6
GO:0008392	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2J5
GO:0008392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2J2 oxidises ARA (Homo sapiens)
GO:0008392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonic acid epoxygenase activity
REACT:R-CFA-77309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Canis familiaris)
RHEA:55698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate => a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O
REACT:R-SCE-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Saccharomyces cerevisiae)
RHEA:22367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-quinate + NAD(+) <=> 3-dehydroquinate + H(+) + NADH
GO:0047424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylenediurea aminohydrolase activity
GO:0047424	skos:altLabel	"methylenediurease"
GO:0047424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylenediurease activity
GO:0047424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylenediurea deaminase"
GO:0047424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 H2O + methylenediurea = CO2 + N-(hydroxymethyl)urea + 2 NH4(+)
GO:0047424	skos:prefLabel	"methylenediurea deaminase"
GO:0047424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenediurea deaminase activity
REACT:R-DME-5654163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds PLCG1 (Drosophila melanogaster)
GO:0019120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In C-halide compounds"
GO:0019120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid halide bonds, in C-halide compounds
GO:0019120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Homo sapiens)
GO:0019120	skos:prefLabel	"In C-halide compounds"
RHEA:52742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminomethylphosphonate + glyoxylate + H(+) + H2O2 => glyphosate + H2O + O2
RHEA:55907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloro-L-tryptophan + chloride + FADH2 + O2 <=> 6,7-dichloro-L-tryptophan + FAD + 2 H2O
RHEA:59229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-alpha-D-quinovose => 6-sulfo-beta-D-quinovose
REACT:R-DRE-2065357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)
REACT:R-MMU-158609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers CH3 from AdoMet to 6MP (Mus musculus)
RHEA:27995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + xanthosine => D-ribose + xanthine
REACT:R-SSC-8854051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL18 ubiquitinates FBXL7 (Sus scrofa)
REACT:R-BTA-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Bos taurus)
REACT:R-CFA-1067667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R (Canis familiaris)
RHEA:38794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-5693086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACE1(46-501) translocates from Golgi lumen to plasma membrane (Homo sapiens)
RHEA:38180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-1237047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ hydrates CO2 to HCO3- (Bos taurus)
REACT:R-HSA-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
RHEA:72433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-AMP + diphosphate => (E)-caffeate + ATP + H(+)
REACT:R-XTR-375160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 binds to ATP (Xenopus tropicalis)
REACT:R-DRE-5654148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR3 (Danio rerio)
REACT:R-SSC-159443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Sus scrofa)
RHEA:19516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + L-ornithine <=> H(+) + L-citrulline + phosphate
RHEA:32329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + zerumbone => 10-hydroxy-alpha-humulene + NAD(+)
REACT:R-DME-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Drosophila melanogaster)
RHEA:51729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + H2O => dihydroxyacetone + phosphate
REACT:R-CFA-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Canis familiaris)
RHEA:54103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-SPO-1482892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Schizosaccharomyces pombe)
RHEA:42437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] => L-ascorbate 6-phosphate(in) + L-histidyl-[protein]
RHEA:62225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + neopatulin => (E)-ascladiol + NADP(+)
REACT:R-DME-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Drosophila melanogaster)
REACT:R-MMU-870479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)
RHEA:48400	skos:altLabel	"HIF hydroxylase"
RHEA:48400	skos:prefLabel	"hypoxia-inducible factor-proline dioxygenase"
RHEA:48400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hypoxia-inducible factor-proline dioxygenase"
RHEA:48400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]
RHEA:24516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gentamicin 2'-N-acetyltransferase"
RHEA:24516	skos:prefLabel	"gentamicin 2'-N-acetyltransferase"
RHEA:24516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + gentamicin C1a = CoA + H(+) + N(2')-acetylgentamicin C1a
RHEA:24516	skos:altLabel	"gentamycin acetyltransferase II"
REACT:R-MMU-399952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIMK-1 by PAK (Mus musculus)
RHEA:11754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + salicylate => acetylsalicylate + H2O
RHEA:12290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + L-fucose => an alpha-L-fucoside + H2O
REACT:R-SSC-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Sus scrofa)
RHEA:51255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
REACT:R-XTR-5649854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to oxidatively damaged AP site (Xenopus tropicalis)
REACT:R-DRE-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)
REACT:R-CFA-5263616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeO2H is reduced to MeSeOH by TXNRD1 (Canis familiaris)
RHEA:55715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)
RHEA:30612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-zeta-carotene => AH2 + all-trans-neurosporene
GO:0098620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	seryl-selenocysteinyl-tRNA kinase activity
GO:0098620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK (Homo sapiens)
RHEA:43130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => guanosine(10) in tRNA + S-adenosyl-L-methionine
RHEA:23324	skos:altLabel	"yeast 2'-phosphotransferase"
RHEA:23324	skos:prefLabel	"2'-phosphotransferase"
RHEA:23324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-phospho-[ligated tRNA] + NAD(+) = ADP-beta-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide
RHEA:23324	skos:altLabel	"Tpt1p"
RHEA:23324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-phosphotransferase"
REACT:R-DRE-3229089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Danio rerio)
REACT:R-CEL-354066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
REACT:R-CFA-6784959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPHL hydrolyses VACV to ACV (Canis familiaris)
REACT:R-HSA-109863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK3:MAP2K1 (Homo sapiens)
RHEA:16510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxalate => CO2 + formate
REACT:R-SSC-8938930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF2 (Sus scrofa)
GO:0043184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Flk-1 binding
GO:0043184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinase domain region binding
GO:0043184	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	KDR binding
GO:0043184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR 2 binding
GO:0043184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF receptor 2 binding
GO:0043184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vascular endothelial growth factor receptor 2 binding
RHEA:71335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-tryptophan(out) + 2 Na(+)(out) = chloride(in) + L-tryptophan(in) + 2 Na(+)(in)
RHEA:53730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-muramate + phosphate => H2O + N-acetyl-D-muramate 6-phosphate
REACT:R-MMU-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Mus musculus)
RHEA:18657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH
RHEA:38256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + succinyl-CoA => (S)-malyl-CoA + succinate
RHEA:46259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-1483077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE transports from the mitochondrial membrane to the ER (Homo sapiens)
REACT:R-SSC-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Sus scrofa)
GO:0015035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein disulphide oxidoreductase activity
GO:0015035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-disulfide reductase activity
GO:0015035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide disulphide oxidoreductase activity
GO:0015035	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	haem lyase disulphide oxidoreductase activity
GO:0015035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide disulfide oxidoreductase activity
GO:0015035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein disulfide oxidoreductase activity
GO:0015035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein disulfide-oxidoreductase activity
GO:0015035	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heme lyase disulfide oxidoreductase activity
RHEA:38654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)
REACT:R-CEL-425822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Caenorhabditis elegans)
RHEA:59983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTP + H2O <=> 8-oxo-dGDP + H(+) + phosphate
REACT:R-MMU-2197698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src phosphorylate WASP,N-WASP (Mus musculus)
RHEA:38611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamide
REACT:R-XTR-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Xenopus tropicalis)
RHEA:21842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine
RHEA:62711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoate + UDP-alpha-D-glucose <=> 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP
GO:0140807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-protein-glutamate ADP-ribosyltransferase activity
RHEA:26425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + thyroxine <=> adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate
REACT:R-MMU-204824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Ang4 (Mus musculus)
RHEA:67788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin
RHEA:68709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => diphosphate + linalool
RHEA:44539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-5690080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP3,SAGA deubiquitinate Histone H2A,H2B (Canis familiaris)
REACT:R-SSC-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Sus scrofa)
REACT:R-PFA-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Plasmodium falciparum)
GO:1990624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanyl nucleotide exchange factor inhibitor activity
RHEA:43757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]
RHEA:54886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NADP(+)
GO:0008764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-Mur-NAC-L-Ala:D-Glu ligase activity
GO:0008764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity
GO:0008764	skos:altLabel	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase"
GO:0008764	skos:altLabel	"D-glutamate ligase"
GO:0008764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
GO:0008764	skos:altLabel	"UDP-N-acetylmuramoylalanine--D-glutamate ligase"
GO:0008764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
GO:0008764	skos:prefLabel	"UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase"
GO:0008764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)
GO:0008764	skos:altLabel	"UDP-Mur-NAC-L-Ala:D-Glu ligase"
GO:0008764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamate-adding enzyme activity
GO:0008764	skos:altLabel	"D-glutamate-adding enzyme"
GO:0008764	skos:altLabel	"uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase"
GO:0008764	skos:altLabel	"MurD synthetase"
GO:0008764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity
GO:0008764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase"
GO:0008764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamate ligase activity
GO:0008764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MurD synthetase activity
RHEA:18202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
REACT:R-BTA-9018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds interacting proteins at the endosome membrane (Bos taurus)
REACT:R-BTA-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Bos taurus)
REACT:R-BTA-374723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nociceptin receptor binds to nociceptin (Bos taurus)
REACT:R-DRE-2328037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds integrins (Danio rerio)
RHEA:42159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone + H(+) + NADPH <=> 5alpha-androstane-3alpha,17beta-diol + NADP(+)
REACT:R-BTA-422048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acyl Ghrelin and C-Ghrelin are secreted (Bos taurus)
REACT:R-CFA-9632918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Canis familiaris)
GO:0070878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	primary miRNA binding
GO:0070878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	primary microRNA binding
GO:0070878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pri-miRNA binding
REACT:R-RNO-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Rattus norvegicus)
REACT:R-GGA-165777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4B by activated S6K1 (Gallus gallus)
RHEA:20276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
RHEA:48252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD2 + UDP-alpha-D-galactose = ganglioside GD1b + H(+) + UDP
GO:0030235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric-oxide synthase regulator activity
GO:0030235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide synthase regulator activity
RHEA:31665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => 2-oxoglutarate + UDP-N-acetylbacillosamine
REACT:R-RNO-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Rattus norvegicus)
REACT:R-HSA-6799959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP3,4 binds bacterial peptidoglycan (Homo sapiens)
REACT:R-DME-6781905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZRANB1 binds APC (Drosophila melanogaster)
RHEA:67327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine <=> (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine
REACT:R-MMU-433089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT can transport taurolithocholate-3-sulphate (Mus musculus)
RHEA:68190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + dodecanoate phytyl ester => dodecanoyl-CoA + phytol
REACT:R-MMU-5228521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Mus musculus)
GO:0033462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine tRNA
GO:0033462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGC codon-amino acid adaptor activity
RHEA:43820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:70583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-CFA-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Canis familiaris)
REACT:R-BTA-4090390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates AR with SUMO1 (Bos taurus)
RHEA:43244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate
RHEA:15721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine dehydrogenase"
RHEA:15721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H2O + NAD(+) = glyoxylate + H(+) + NADH + NH4(+)
RHEA:15721	skos:prefLabel	"glycine dehydrogenase"
REACT:R-DME-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Drosophila melanogaster)
REACT:R-MMU-388900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurotensin receptors can bind neurotensins (Mus musculus)
REACT:R-SSC-1655851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2P hydrolyzes SREBP1A,1C,2 (Sus scrofa)
REACT:R-HSA-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Homo sapiens)
REACT:R-HSA-9717202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
RHEA:68678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+) => 3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate)
REACT:R-XTR-112042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid binds MOR (Xenopus tropicalis)
RHEA:41662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + sanguinarine => dihydrosanguinarine + NAD(+)
REACT:R-XTR-158609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers CH3 from AdoMet to 6MP (Xenopus tropicalis)
RHEA:22027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + trimethylamine <=> 2 H(+) + NADH + trimethylamine N-oxide
RHEA:31158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) <=> (4S)-4-hydroxy-L-glutamate + H(+) + NADH
REACT:R-SSC-1678660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan sulfate chain(3) (Sus scrofa)
REACT:R-XTR-4755494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Xenopus tropicalis)
REACT:R-XTR-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Xenopus tropicalis)
RHEA:13609	skos:altLabel	"type III PIP kinase"
RHEA:13609	skos:altLabel	"phosphatidylinositol 3-phosphate 5-kinase"
RHEA:13609	skos:prefLabel	"1-phosphatidylinositol-3-phosphate 5-kinase"
RHEA:13609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-phosphatidylinositol-3-phosphate 5-kinase"
RHEA:13609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)
RHEA:25819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + norspermine + O2 <=> 3-aminopropanal + H2O2 + norspermidine
REACT:R-MMU-5668605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2:GTP binds NOX2 complex (Mus musculus)
RHEA:11161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-2,4-diaminobutanoate => L-aspartate 4-semialdehyde + L-glutamate
REACT:R-MMU-1471314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNP1-3 bind CD4 (Mus musculus)
REACT:R-MMU-1592316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP1 (Mus musculus)
RHEA:60680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic aldehyde + H2O + NADP(+) = (+)-artemisinate + 2 H(+) + NADPH
REACT:R-BTA-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Bos taurus)
REACT:R-BTA-9632906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ recruits RAS in response to estrogen stimulation (Bos taurus)
REACT:R-SSC-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Sus scrofa)
REACT:R-HSA-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Homo sapiens)
REACT:R-MMU-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Mus musculus)
GO:0050355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic triphosphate phosphatase activity
GO:0050355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triphosphate phosphohydrolase activity
GO:0050355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inorganic triphosphatase activity
GO:0050355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tripolyphosphatase activity
GO:0050355	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	triphosphatase activity
REACT:R-DME-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Drosophila melanogaster)
GO:0005024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGF-beta receptor activity
GO:0005024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor beta-activated receptor activity
GO:0005024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFbeta receptor activity
GO:0005024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFbeta-activated receptor activity
GO:0005024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFbetaR
GO:0005024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor beta receptor activity
REACT:R-SSC-8983371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Sus scrofa)
REACT:R-DRE-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Danio rerio)
RHEA:37895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + protodioscin = 26-deglucoprotodioscin + D-glucose
RHEA:37895	skos:altLabel	"furostanol 26-O-beta-D-glucoside glucohydrolase"
RHEA:37895	skos:prefLabel	"protodioscin 26-O-beta-D-glucosidase"
RHEA:37895	skos:altLabel	"furostanol glycoside 26-O-beta-D-glucosidase"
RHEA:37895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protodioscin 26-O-beta-D-glucosidase"
RHEA:37895	skos:altLabel	"torvosidase"
GO:0047146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterigmatocystin 7-O-methyltransferase activity
GO:0047146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity
GO:0047146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-methyltransferase II activity
GO:0047146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterigmatocystin 8-O-methyltransferase activity
GO:0047146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity
GO:0047146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterigmatocystin methyltransferase activity
RHEA:71204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoarginine(in) => L-homoarginine(out)
REACT:R-GGA-9611751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1,2-agonists bind ADRB1,2 (Gallus gallus)
RHEA:42529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(955/2504/2580) in 23S rRNA => pseudouridine(955/2504/2580) in 23S rRNA
RHEA:65030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin] => (+)-pinoresinol + H2O + 2 oxidized [azurin]
RHEA:46560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SPO-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Schizosaccharomyces pombe)
RHEA:42638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + L-alanine + thio-Mo-molybdopterin => AH2 + L-cysteine + Mo-molybdopterin
GO:0102263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-dihydrouridine17 synthase activity
RHEA:29664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + xanthine(in) => H(+)(out) + xanthine(out)
RHEA:48997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylcatechol + O2 => 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)
RHEA:57975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Danio rerio)
RHEA:48628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:72479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + trans-aconitate(in) = citrate(in) + trans-aconitate(out)
REACT:R-RNO-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Rattus norvegicus)
RHEA:19379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + riboflavin => NADP(+) + reduced riboflavin
EC:2.5.1.74	skos:prefLabel	"1,4-dihydroxy-2-naphthoate polyprenyltransferase"
EC:2.5.1.74	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,4-dihydroxy-2-naphthoate polyprenyltransferase"
REACT:R-SCE-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Saccharomyces cerevisiae)
REACT:R-RNO-5686625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAIR1 binds collagen (Rattus norvegicus)
REACT:R-RNO-176250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR-ATRIP to the RPA-ssDNA complex (Rattus norvegicus)
RHEA:72072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + NAD(+) => H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide
REACT:R-PFA-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Plasmodium falciparum)
REACT:R-RNO-374663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Ezrin (Rattus norvegicus)
GO:0004371	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetol kinase (phosphorylating)
GO:0004371	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyacetone kinase activity
GO:0004371	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetol kinase activity
GO:0004371	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:glycerone phosphotransferase activity
GO:0004371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerone kinase activity
EC:1.14.19.50	skos:prefLabel	"noroxomaritidine synthase"
EC:1.14.19.50	skos:altLabel	"CYP96T1"
EC:1.14.19.50	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"noroxomaritidine synthase"
GO:0033807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	icosanoyl-CoA synthase activity
GO:0033807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	stearoyl-CoA elongase activity
GO:0033807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA elongase activity
GO:0033807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity
GO:0033807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C18-CoA elongase activity
REACT:R-CFA-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Canis familiaris)
REACT:R-CFA-211178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO1A is excluded from the nucleus (Canis familiaris)
REACT:R-BTA-421007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of Ca impermeable AMPA receptors (Bos taurus)
REACT:R-HSA-8950780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 binds p-Y693-STAT4 (Homo sapiens)
REACT:R-SSC-2559568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Sus scrofa)
RHEA:46899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)
REACT:R-CEL-5695964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD14B hydrolyses PNPB (Caenorhabditis elegans)
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-galactocerebrosidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactosylceramidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cerebroside beta-galactosidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ceramide galactosidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactosylceramidase I
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galcerase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosylceramidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosylceramide beta-galactosidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactosyl-N-acylsphingosine galactohydrolase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosylcerebrosidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-galactosylceramidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactocerebroside galactosidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactocerebroside-beta-D-galactosidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactocerebroside beta-galactosidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosylceramidase I
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactocerebrosidase activity
GO:0004336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cerebroside galactosidase activity
GO:0046978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAP1 binding
REACT:R-DME-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)
RHEA:38462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA <=> 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA
REACT:R-HSA-183122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3b-bound Factor B (Homo sapiens)
RHEA:43113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelate + NAD(+) => H(+) + NADH + phenylglyoxylate
REACT:R-CEL-8959510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)
RHEA:17681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH
RHEA:58708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin ortho-naphthoquinone carboxamide = rifampicin para-naphthoquinone carboxamide
RHEA:40089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-oxodocosanoate + H(+) + NADH => 22-hydroxydocosanoate + NAD(+)
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E. coli endonuclease IV
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endonuclease IV activity
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Escherichia coli endonuclease II
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-adenine-transferase activity
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonuclease IV (phage T4-induced) activity
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	redoxyendonuclease activity
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxriboendonuclease activity
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endodeoxyribonuclease IV (phage T4-induced) activity
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endonuclease II
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonuclease IV (phage-T4-induced) activity
GO:0008833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endodeoxyribonuclease IV (phage T(4)-induced) activity
REACT:R-SSC-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Sus scrofa)
RHEA:50337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate => H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Caenorhabditis elegans)
REACT:R-DRE-3640872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP34 deubiquitinates AXIN1,AXIN2 (Danio rerio)
RHEA:43915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:47699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate
REACT:R-SSC-2993763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Sus scrofa)
EC:1.1.1.237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyphenylpyruvate reductase"
EC:1.1.1.237	skos:prefLabel	"hydroxyphenylpyruvate reductase"
RHEA:59505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + glycyl-L-cysteinyl-[protein] + H(+) => [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]
REACT:R-SSC-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Sus scrofa)
RHEA:72958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + nicotinate(out) <=> 2 Na(+)(in) + nicotinate(in)
GO:0009034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan indole-lyase (deaminating; pyruvate forming) activity
GO:0009034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan indole-lyase (deaminating) activity
GO:0009034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan indole-lyase activity
GO:0009034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophanase activity
GO:0009034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan catabolism, using tryptophanase
GO:0009034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophanase activity
GO:0009034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TNase activity
GO:0009034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan catabolic process, using tryptophanase
RHEA:36421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine
REACT:R-HSA-8964246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in G alpha (12)-BTK complex is activated (Homo sapiens)
REACT:R-CEL-5694494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)
RHEA:36963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA
RHEA:48288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM3 = CMP + ganglioside GD3 + H(+)
REACT:R-SPO-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Schizosaccharomyces pombe)
RHEA:38482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine
RHEA:51773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + phlorisobutanophenone => 4-prenylphlorisobutanophenone + diphosphate
RHEA:18329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,3R,5S)-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH
RHEA:18329	skos:prefLabel	"(+)-sabinol dehydrogenase"
RHEA:18329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-sabinol dehydrogenase"
RHEA:20578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyaminophenol => aminohydroquinone
REACT:R-RNO-6800200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-HGF to form HGF dimer (Rattus norvegicus)
RHEA:45716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N,N-trimethylglycyl-CoA = CoA + glycine betaine + H(+)
GO:0004473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-specific malic enzyme
GO:0004473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-malic enzyme activity
GO:0004473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate dehydrogenase (NADP, decarboxylating)
GO:0004473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	'malic' enzyme
GO:0004473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-specific malate dehydrogenase activity
GO:0004473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-malate:NADP oxidoreductase activity
GO:0004473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate dehydrogenase (decarboxylating, NADP)
GO:0004473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-linked decarboxylating malic enzyme
GO:0004473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
GO:0004473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate dehydrogenase (decarboxylating) (NADP+) activity
REACT:R-BTA-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Bos taurus)
REACT:R-XTR-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Xenopus tropicalis)
RHEA:71005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(out) + L-phenylalanine(in) => L-histidine(in) + L-phenylalanine(out)
RHEA:44220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxypentadecanoate + ATP + CoA = 15-hydroxypentadecanoyl-CoA + AMP + diphosphate
RHEA:71976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(out) + 3 Na(+)(out) => glutathione(in) + 3 Na(+)(in)
GO:0070573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metallo-exo-dipeptidase activity
GO:0070573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
GO:0070573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metallodipeptidase activity
GO:0070573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloexodipeptidase activity
RHEA:63094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ilicicolin A epoxide + NADP(+) => H(+) + ilicicolin A + NADPH + O2
RHEA:65305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + verruculide A => chrodrimanin T + CO2 + succinate
RHEA:70584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:20980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bilirubin oxidase"
RHEA:20980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 bilirubin IXalpha + O2 = 2 biliverdin IXalpha + 2 H2O
RHEA:20980	skos:prefLabel	"bilirubin oxidase"
REACT:R-HSA-9609860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP (Homo sapiens)
RHEA:72369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(in) + succinate(out) => estrone 3-sulfate(out) + succinate(in)
GO:0004970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ionotropic glutamate receptor activity
REACT:R-DRE-9014449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the plasma membrane (Danio rerio)
EC:5.1.99.-	skos:prefLabel	"Acting on other compounds"
EC:5.1.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on other compounds"
RHEA:44023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + octadecanal <=> 2 H(+) + NADH + octadecanoate
RHEA:54728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]
RHEA:54728	skos:prefLabel	"acetyl-CoA carboxytransferase"
RHEA:54728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetyl-CoA carboxytransferase"
RHEA:56571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine <=> globoside IV3GalNAc-Gb4Cer + H(+) + UDP
RHEA:59212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP = AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]
RHEA:27798	skos:altLabel	"trans-heptaprenyltranstransferase"
RHEA:27798	skos:altLabel	"octaprenyl pyrophosphate synthetase"
RHEA:27798	skos:altLabel	"trans-prenyltransferase"
RHEA:27798	skos:prefLabel	"all-trans-octaprenyl-diphosphate synthase"
RHEA:27798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-octaprenyl-diphosphate synthase"
RHEA:27798	skos:altLabel	"terpenyl pyrophosphate synthetase"
RHEA:27798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = all-trans-octaprenyl diphosphate + 5 diphosphate
REACT:R-SSC-453183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y348-SYK dissociates (Sus scrofa)
REACT:R-DRE-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Danio rerio)
REACT:R-XTR-6810472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT13 hydrolyses AP6A to AP4 and ADP (Xenopus tropicalis)
REACT:R-HSA-9681382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT mutants bind ripretinib (Homo sapiens)
REACT:R-CFA-9609742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Canis familiaris)
RHEA:23691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + H(+) + H2O <=> hypoxanthine + NH4(+)
REACT:R-SSC-2453863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRA6 transports atROL from extracellular region to cytosol (Sus scrofa)
RHEA:68627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]
RHEA:39229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octacosanoyl-CoA => (2E)-octacosenoyl-CoA + H(+) + NADPH
REACT:R-XTR-374909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabolism of Noradrenaline (Xenopus tropicalis)
EC:4.1.99.5	skos:prefLabel	"aldehyde oxygenase (deformylating)"
EC:4.1.99.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldehyde oxygenase (deformylating)"
EC:4.1.99.5	skos:altLabel	"aldehyde decarbonylase"
REACT:R-DRE-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Danio rerio)
REACT:R-DRE-5668454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Danio rerio)
REACT:R-GGA-140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequestered tissue factor -> tissue factor (Gallus gallus)
REACT:R-HSA-1791131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PDIA6 (Protein disulfide-isomerase A6) (Homo sapiens)
REACT:R-DRE-4551721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VHL with SUMO1 (Danio rerio)
REACT:R-MMU-445813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Smooth Muscle Myosin Light Chains (Mus musculus)
REACT:R-XTR-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Xenopus tropicalis)
RHEA:14018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-nicotinamide D-riboside => ADP + beta-nicotinamide D-ribonucleotide + H(+)
REACT:R-HSA-9014424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the phagocytic vesicle membrane (Homo sapiens)
RHEA:21633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 catechol + O2 => 2 1,2-benzoquinone + 2 H2O
REACT:R-MMU-70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Mus musculus)
EC:1.22.-.-	skos:prefLabel	"Acting on halogen in donors"
EC:1.22.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on halogen in donors"
REACT:R-SSC-606326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HJURP:CENPA complex localizes to the centromere (Sus scrofa)
RHEA:16228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-diazacyclotetradecane-2,9-dione + H2O <=> N-(6-aminohexanoyl)-6-aminohexanoate
REACT:R-GGA-5610733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Gallus gallus)
RHEA:46824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:18926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulono-1,4-lactone + NADP(+) => D-glucurono-3,6-lactone + H(+) + NADPH
RHEA:55512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-194632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Mus musculus)
REACT:R-RNO-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Rattus norvegicus)
REACT:R-MMU-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
REACT:R-XTR-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
REACT:R-XTR-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Xenopus tropicalis)
REACT:R-XTR-2168884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Methemoglobin to Hemopexin (Xenopus tropicalis)
RHEA:33734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin
REACT:R-DME-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Drosophila melanogaster)
RHEA:70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)
GO:0051018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase A binding
GO:0051018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA binding
GO:0051018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein kinase A anchoring activity
RHEA:22277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoaldehyde + H2O + NAD(+) => a 2-oxocarboxylate + 2 H(+) + NADH
REACT:R-DRE-1470009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs (Danio rerio)
REACT:R-HSA-549385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRY:PER:Kinase complex translocates to the nucleus (Homo sapiens)
REACT:R-XTR-975608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP2:atROL and FACYLs to atREs (Xenopus tropicalis)
REACT:R-MMU-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Mus musculus)
REACT:R-BTA-914036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Bos taurus)
GO:0015343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	siderophore transporter activity
GO:0015343	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	siderochrome transporter activity
GO:0015343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	siderophore-iron transporter activity
GO:0015343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	siderophore transmembrane transporter activity
GO:0015343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	siderophore-iron transmembrane transporter activity
GO:0015343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-siderophore transporter activity
GO:0015343	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	siderochrome-iron transporter activity
REACT:R-RNO-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Rattus norvegicus)
REACT:R-MMU-141040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)
REACT:R-PFA-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Plasmodium falciparum)
REACT:R-HSA-8858369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVRL1 binds BMP9,BMP10 (Homo sapiens)
REACT:R-CFA-159771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein C to protein C (Canis familiaris)
REACT:R-CFA-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Canis familiaris)
RHEA:40515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose 1-phosphate = (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate
RHEA:40515	skos:prefLabel	"sulfofructosephosphate aldolase"
RHEA:40515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfofructosephosphate aldolase"
REACT:R-DRE-8948832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 polyubiquitinates PARylated PTEN (Danio rerio)
REACT:R-DRE-9027302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)
REACT:R-DME-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)
REACT:R-MMU-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Mus musculus)
GO:0004555	skos:prefLabel	"alpha,alpha-trehalase"
GO:0004555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalase activity
GO:0004555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose
GO:0004555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha,alpha-trehalose glucohydrolase activity
GO:0004555	skos:altLabel	"trehalase"
GO:0004555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha,alpha-trehalase"
REACT:R-BTA-3209165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ID1 sequesters ETS2 (Bos taurus)
RHEA:57391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) <=> (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH
REACT:R-RNO-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Rattus norvegicus)
REACT:R-SSC-199910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates ATF1 (Sus scrofa)
RHEA:25065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) <=> 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH
RHEA:36917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA
RHEA:37808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:58844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeranial + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH
REACT:R-DME-5654165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR1 (Drosophila melanogaster)
RHEA:40885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+)
REACT:R-HSA-9035956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP17A1 does not cleave 17aHPROG (Homo sapiens)
REACT:R-SSC-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Sus scrofa)
RHEA:44591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol
RHEA:20640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + D-glucose <=> D-glucono-1,5-lactone + D-sorbitol
REACT:R-SSC-9638064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Sus scrofa)
REACT:R-HSA-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Homo sapiens)
RHEA:44753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-163120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)
REACT:R-RNO-2022061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan sulfate can be further sulfated on position 2 of iduronate (Rattus norvegicus)
REACT:R-CFA-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Canis familiaris)
RHEA:53766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholoyl-CoA + lithocholate => allocholate + lithocholoyl-CoA
RHEA:70608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 4-ethylphenol => 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-MMU-1678921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length TLR3/7/8/9 binds to UNC93B1 (Mus musculus)
RHEA:71446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-methyl-L-dopa(out) + L-phenylalanine(in) <=> 3-O-methyl-L-dopa(in) + L-phenylalanine(out)
REACT:R-SSC-9718020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PTGFR agonists (Sus scrofa)
REACT:R-BTA-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)
RHEA:51034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichlorochromopyrrolate + H(+) + NH4(+) => 7-chloroindole-3-pyruvate imine dimer
RHEA:29888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-lysine(out) => ADP + H(+) + L-lysine(in) + phosphate
REACT:R-CEL-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Caenorhabditis elegans)
REACT:R-RNO-77277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Rattus norvegicus)
RHEA:26340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + S-methyl-L-methionine <=> H(+) + 2 L-methionine
REACT:R-XTR-2395328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP1, LTBP3 bind TGF-Beta (Xenopus tropicalis)
RHEA:42810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite => 2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-RNO-8871226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA2 (Rattus norvegicus)
REACT:R-SSC-114600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Sus scrofa)
REACT:R-SCE-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Saccharomyces cerevisiae)
RHEA:72402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + estrone 3-sulfate(in) <=> 2-oxoglutarate(in) + estrone 3-sulfate(out)
REACT:R-XTR-8985988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Xenopus tropicalis)
REACT:R-CFA-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Canis familiaris)
RHEA:20421	skos:altLabel	"phospho-alpha-glucosidase"
RHEA:20421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate
RHEA:20421	skos:prefLabel	"maltose-6'-phosphate glucosidase"
RHEA:20421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maltose-6'-phosphate glucosidase"
REACT:R-CEL-6808487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
RHEA:60637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(dodecanoyl)-sphing-4-enine-1-phosphocholine => choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate
RHEA:46340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-hexadecanoylsphing-4-enine = ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate
REACT:R-DDI-199425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLPP dephosphorylates S473 in AKT (Dictyostelium discoideum)
RHEA:13266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine
GO:0047779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citrate--CoA ligase"
GO:0047779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate:CoA ligase activity
GO:0047779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + CoA = (3S)-citryl-CoA + ADP + phosphate
GO:0047779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate thiokinase activity
GO:0047779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate-CoA ligase activity
GO:0047779	skos:prefLabel	"citrate--CoA ligase"
GO:0047779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citryl-CoA synthetase activity
GO:0047779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate:CoA ligase (ADP-forming)
REACT:R-MMU-158832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT2 (Mus musculus)
REACT:R-PFA-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)
REACT:R-RNO-9013023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GEFs activate RHOB (Rattus norvegicus)
GO:0033795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine reductase activity
GO:0033795	skos:prefLabel	"betaine reductase"
GO:0033795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"betaine reductase"
GO:0033795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity
GO:0033795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate
RHEA:36267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + theobromine
REACT:R-MMU-399933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sema3A binds Nrp-1 bound to PlexinA (Mus musculus)
REACT:R-CEL-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Caenorhabditis elegans)
REACT:R-DRE-3697882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN (Danio rerio)
REACT:R-DRE-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Danio rerio)
GO:0103002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxypalmitate dehydrogenase activity
RHEA:71755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + 2-oxoheptanedioate(in) = 2-oxoglutarate(in) + 2-oxoheptanedioate(out)
RHEA:45231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3E)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA
RHEA:71792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate(in) + H(+)(in) => (R)-lactate(out) + H(+)(out)
REACT:R-SSC-917839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-Transferrin dissociates from the receptor complex (Sus scrofa)
REACT:R-DRE-382052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130Cas and C3G bind PDGFR bound Crk (Danio rerio)
RHEA:51892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylcadaverine = acetate + cadaverine
REACT:R-GGA-5676595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAFs bind RANK:RANKL (Gallus gallus)
REACT:R-RNO-9009554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer:SDC1 binds CSF1R (Rattus norvegicus)
GO:0015395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	equilibrative nucleoside transporter activity
GO:0015395	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity
GO:0015395	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity
GO:0015395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside transmembrane transporter activity, down a concentration gradient
REACT:R-PFA-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Plasmodium falciparum)
RHEA:28029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dUDP + H2O <=> [thioredoxin]-dithiol + UDP
REACT:R-RNO-432096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)
RHEA:47934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactate + 2 H(+) + NADH => (2S)-3-sulfolactaldehyde + H2O + NAD(+)
REACT:R-HSA-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Homo sapiens)
REACT:R-MMU-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Mus musculus)
REACT:R-HSA-5662662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosinase oxidises tyrosine to dopaquinone (Homo sapiens)
RHEA:52983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]
RHEA:55702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate => an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O
RHEA:19514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + L-ornithine => H(+) + L-citrulline + phosphate
RHEA:66324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide(out) = iodide(in)
REACT:R-BTA-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Bos taurus)
REACT:R-CFA-981728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to membrane-associated C3b (Canis familiaris)
REACT:R-DRE-5674132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Danio rerio)
RHEA:69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + glycine
REACT:R-MMU-1605595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Mus musculus)
RHEA:40177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H2O2 => O2 + octanoyl-CoA
RHEA:52713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + H2O => 2-deoxy-D-ribose 5-phosphate + thymine
RHEA:62495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-arginine <=> AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]
REACT:R-CEL-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Caenorhabditis elegans)
RHEA:23776	skos:altLabel	"aspartokinase"
RHEA:23776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate kinase"
RHEA:23776	skos:prefLabel	"aspartate kinase"
RHEA:23776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate = 4-phospho-L-aspartate + ADP
REACT:R-SSC-2160851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAS1,2,3 mediate the polymerisation of HA (Sus scrofa)
RHEA:53322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose
REACT:R-DRE-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Danio rerio)
REACT:R-SSC-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Sus scrofa)
RHEA:15799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin IXalpha + H(+) + NADH => bilirubin IXalpha + NAD(+)
REACT:R-CEL-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Caenorhabditis elegans)
RHEA:35125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanyl-D-glutamate(in) => H(+)(out) + L-alanyl-D-glutamate(out)
REACT:R-MMU-6805620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A and PML bind TP53 (Mus musculus)
REACT:R-CFA-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Canis familiaris)
RHEA:50196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citramalate pyruvate lyase activity
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citramalate synthetase activity
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-citramalate pyruvate-lyase activity
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citramalate lyase activity
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalate = acetate + pyruvate
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citramalate lyase"
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citramalic-condensing enzyme
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-citramalate pyruvate-lyase (acetate-forming)
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citramalate pyruvate-lyase activity
GO:0047776	skos:prefLabel	"citramalate lyase"
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citramalic synthase activity
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-citramalate lyase activity
GO:0047776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-citramalate pyruvate-lyase activity
GO:0047776	skos:altLabel	"(3S)-citramalate pyruvate-lyase"
REACT:R-BTA-8874718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA binds alpha-TOH (Bos taurus)
REACT:R-DDI-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Dictyostelium discoideum)
RHEA:51388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dopamine = CoA + H(+) + N-acetyl-dopamine
RHEA:66446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hexen-3-one + H(+) + NADPH => hexan-3-one + NADP(+)
RHEA:13328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate
RHEA:46827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:46211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + eicosanoate <=> AMP + diphosphate + eicosanoyl-CoA
REACT:R-DME-8936584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)
RHEA:57789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite
REACT:R-MMU-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Mus musculus)
REACT:R-HSA-162840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane (Homo sapiens)
REACT:R-CEL-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Caenorhabditis elegans)
REACT:R-DME-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Drosophila melanogaster)
REACT:R-GGA-391158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP alpha binds CD47 (Gallus gallus)
RHEA:60571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-tryptophan <=> N-acetyl-D-tryptophan
REACT:R-HSA-8964284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in active Gq-BTK complex is activated (Homo sapiens)
REACT:R-DRE-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Danio rerio)
RHEA:57409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH
REACT:R-HSA-2197691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIP binds WASP,N-WASP, activating them (Homo sapiens)
GO:0033889	skos:prefLabel	"N-sulfoglucosamine-3-sulfatase"
GO:0033889	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinsulfatase activity
GO:0033889	skos:altLabel	"chondroitinsulfatase"
GO:0033889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-sulfoglucosamine-3-sulfatase"
GO:0033889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-sulfoglucosamine-3-sulfatase activity
GO:0033889	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity
GO:0036188	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	abietadienal dehydrogenase
GO:0036188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-al dehydrogenase activity
REACT:R-MMU-6805122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB binds TP53 (Mus musculus)
GO:0016636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With an iron-sulfur protein as acceptor"
GO:0016636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor
GO:0016636	skos:prefLabel	"With an iron-sulfur protein as acceptor"
GO:0016636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
RHEA:71289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-arginine(in) + 2 Na(+)(in) => chloride(out) + L-arginine(out) + 2 Na(+)(out)
RHEA:12668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-deoxystreptamine antibiotic + acetyl-CoA <=> an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)
REACT:R-DDI-76453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A6 (Dictyostelium discoideum)
RHEA:62477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)
REACT:R-BTA-1169404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ISG15 from E1 to E2 (UBCH8) (Bos taurus)
RHEA:21440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP(+)
RHEA:27487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + CO2 + NH4(+) => allantoate + 2 H(+) + H2O
GO:0043743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPPG:FO 2-phospho-L-lactate transferase activity
GO:0102343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-arachidoyl-CoA dehydratase activity
RHEA:68001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1-dichloroethene + AH2 => A + chloride + chloroethene + H(+)
REACT:R-MMU-400682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Rac1 interacts with Plexin-B1:Sema4D (Mus musculus)
REACT:R-HSA-164509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of gp120 of ENV oligomer to the host CD4 (Homo sapiens)
RHEA:38816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine
RHEA:15989	skos:altLabel	"3-hydroxy-3-methylglutaryl-coenzyme A reductase"
RHEA:15989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH
RHEA:15989	skos:prefLabel	"hydroxymethylglutaryl-CoA reductase (NADPH)"
RHEA:15989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxymethylglutaryl-CoA reductase (NADPH)"
RHEA:15989	skos:altLabel	"HMG-CoA reductase"
REACT:R-CEL-3134954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX9 binds DNA (Caenorhabditis elegans)
GO:0102033	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P450 fatty acid omega-hydroxylase activity
GO:0102033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acid omega-hydroxylase activity
REACT:R-HSA-5653770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
RHEA:52404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-O-phospho-L-erythronate + H(+) = CO2 + dihydroxyacetone phosphate
RHEA:54458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:39519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)
REACT:R-MMU-8952039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)
RHEA:72007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate(in) + urate(out) = succinate(out) + urate(in)
RHEA:63419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dichlorohydroquinone + FADH2 + O2 <=> 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O
RHEA:35201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate(in) => (S,S)-tartrate(out)
REACT:R-SSC-9014627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDS dimers:PXLP dehydrate L-Thr to 2AA (Sus scrofa)
RHEA:70764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)
RHEA:13627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-butenal + adenine + AH2 => A + H2O + N(6)-dimethylallyladenine
RHEA:64317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dihydrogeodin + 2 H(+) + O2 => 2 (+)-geodin + 2 H2O
REACT:R-DME-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Drosophila melanogaster)
REACT:R-BTA-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Bos taurus)
REACT:R-SPO-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Schizosaccharomyces pombe)
REACT:R-SSC-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Sus scrofa)
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium transporting ATPase activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	potassium ABC transporter
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	K(+)-transporting ATPase activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	K+-importing ATPase activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium-uptake-ATPase activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent potassium transmembrane transporter activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	K(+)-importing ATPase activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium-transporting ATPase activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-transporting ATPase activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium transmembrane transporter activity, phosphorylative mechanism
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type potassium transmembrane transporter activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	potassium-importing ATPase activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type K(+) transporter"
GO:0008556	skos:altLabel	"K(+)-transporting ATPase"
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled potassium transmembrane transporter activity
GO:0008556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP phosphohydrolase (K+-importing)
GO:0008556	skos:prefLabel	"P-type K(+) transporter"
GO:0008556	skos:altLabel	"K(+)-importing ATPase"
GO:0008556	skos:altLabel	"potassium-importing ATPase"
RHEA:55596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine = globoside NORint + H(+) + UDP
RHEA:64373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O => alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine
RHEA:47977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O
RHEA:18492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate + H(+) + hydrogencarbonate <=> carbamate + CO2
REACT:R-DDI-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Dictyostelium discoideum)
REACT:R-GGA-377644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of CSK from SRC (Gallus gallus)
REACT:R-HSA-8871194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
REACT:R-DRE-193709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
REACT:R-SSC-5213464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is phosphorylated (Sus scrofa)
RHEA:40067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)
REACT:R-DDI-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)
REACT:R-HSA-9731931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds selective ERAs (Homo sapiens)
GO:0005496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid binding
REACT:R-GGA-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Gallus gallus)
REACT:R-DDI-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Dictyostelium discoideum)
REACT:R-BTA-9701507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN6 dephosphorylates JAK3 (Bos taurus)
RHEA:45013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoate
RHEA:34781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxosteroid + H(+) + NADH => a 3alpha-hydroxysteroid + NAD(+)
EC:3.1.21.6	skos:prefLabel	"CC-preferring endodeoxyribonuclease"
EC:3.1.21.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CC-preferring endodeoxyribonuclease"
EC:3.1.21.6	skos:altLabel	"5'-CC-3'-preferring endodeoxyribonuclease"
EC:3.1.21.6	skos:altLabel	"Streptomyces glaucescens exocytoplasmic endonuclease"
EC:3.1.21.6	skos:altLabel	"Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease"
RHEA:63621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dodecanoate + holo-[ACP] => AMP + diphosphate + dodecanoyl-[ACP]
RHEA:14261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucarolactone O-hydroxycinnamoyltransferase"
RHEA:14261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + D-glucono-1,5-lactone = 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA
RHEA:14261	skos:prefLabel	"glucarolactone O-hydroxycinnamoyltransferase"
REACT:R-HSA-9663492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL dissociates from GSTA1, FABP1 (Homo sapiens)
GO:0070579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine (Homo sapiens)
GO:0070579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylcytosine dioxygenase activity
REACT:R-DDI-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
RHEA:20442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + O2 => 3-sulfino-L-alanine + H(+)
REACT:R-DRE-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Danio rerio)
RHEA:40672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminopropanoate + H2O => NH4(+) + pyruvate
GO:0062183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0062183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans retinoic acid 18-hydroxylase activity
REACT:R-MMU-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Mus musculus)
REACT:R-RNO-5685011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR activation at DNA DSBs (Rattus norvegicus)
REACT:R-DRE-9708533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 translocates from the cytosol to the nucleoplasm (Danio rerio)
RHEA:45650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)
GO:0008997	skos:prefLabel	"Exodeoxyribonucleases producing 5'-phosphomonoesters"
GO:0008997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Exodeoxyribonucleases producing 5'-phosphomonoesters"
GO:0008997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease R activity
REACT:R-XTR-140748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Xenopus tropicalis)
RHEA:25844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH
RHEA:25844	skos:altLabel	"carveol dehydrogenase"
RHEA:25844	skos:altLabel	"CDH"
RHEA:25844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5R)-carveol + NAD(+) = (R)-carvone + H(+) + NADH
RHEA:25844	skos:prefLabel	"(-)-trans-carveol dehydrogenase"
RHEA:25844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-trans-carveol dehydrogenase"
RHEA:25844	skos:altLabel	"(4R,6S)-carveol dehydrogenase"
REACT:R-MMU-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Mus musculus)
REACT:R-SSC-158311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Sus scrofa)
RHEA:69425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutanoyl-CoA => acetone + formyl-CoA
REACT:R-RNO-5654584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS bind to PPTN11 (Rattus norvegicus)
REACT:R-MMU-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Mus musculus)
RHEA:63095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ilicicolin A + NADPH + O2 <=> H2O + ilicicolin A epoxide + NADP(+)
RHEA:27688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + GTP => ATP + GDP
RHEA:45841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydecanoyl-CoA + NADP(+) => 3-oxodecanoyl-CoA + H(+) + NADPH
RHEA:66386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scalar-17(25)-en-19-ol => (2E,6E,10E,14E)-geranylfarnesol
REACT:R-CFA-398193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
REACT:R-XTR-2514790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by MMP14 (Xenopus tropicalis)
RHEA:38484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)
RHEA:52382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate
REACT:R-XTR-430135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds ADAP (Xenopus tropicalis)
RHEA:32061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O
RHEA:53653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate
REACT:R-SCE-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Saccharomyces cerevisiae)
RHEA:56210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]
REACT:R-HSA-3225851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)
REACT:R-RNO-194121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:59070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyspectinabilin + S-adenosyl-L-homocysteine => demethyldeoxyspectinabilin + S-adenosyl-L-methionine
RHEA:71597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + succinate(out) => 2-oxoglutarate(out) + succinate(in)
RHEA:51381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + dopamine => CoA + H(+) + N-(9Z-octadecanoyl)-dopamine
REACT:R-CFA-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Canis familiaris)
RHEA:29609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + 2 nitric oxide => H2O + NAD(+) + nitrous oxide
REACT:R-BTA-1483089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is converted to PS by PTDSS2 (Bos taurus)
RHEA:62234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine dimer in DNA => a thymidine(6-4)thymidine in DNA
REACT:R-GGA-573297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation (Gallus gallus)
RHEA:15158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)
GO:1990308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type-I dockerin domain binding
REACT:R-HSA-6793685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated TP53 translocates to the cytosol (Homo sapiens)
RHEA:35635	skos:prefLabel	"anthocyanidin 3-O-coumaroylrutinoside 5-O-glucosyltransferase"
RHEA:35635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanidin 3-O-coumaroylrutinoside 5-O-glucosyltransferase"
RHEA:35635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose = an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP
RHEA:66964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-Man:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-mannosyltransferase"
RHEA:66964	skos:prefLabel	"GDP-Man:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-mannosyltransferase"
RHEA:66964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
RHEA:56654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+)
REACT:R-CFA-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Canis familiaris)
RHEA:20681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-zeatin O-beta-D-glucosyltransferase"
RHEA:20681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-cis-zeatin + UDP
RHEA:20681	skos:prefLabel	"cis-zeatin O-beta-D-glucosyltransferase"
REACT:R-SCE-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Saccharomyces cerevisiae)
REACT:R-SSC-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Sus scrofa)
REACT:R-HSA-977626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b-binding protein binds C4b (Homo sapiens)
RHEA:50100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + taurine = CoA + H(+) + N-dodecanoyl-taurine
RHEA:40037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate => ATP + L-glutamate + N-acetyl-L-aspartate
RHEA:37059	skos:prefLabel	"N(6)-L-threonylcarbamoyladenine synthase"
RHEA:37059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(6)-L-threonylcarbamoyladenine synthase"
RHEA:37059	skos:altLabel	"t6A synthase"
RHEA:37059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA
REACT:R-SSC-508282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK is a substrate for JAK1 (Sus scrofa)
RHEA:46846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2
RHEA:57480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydodecanoate + H2O2 = 2,3-dihydroxydodecanoate + H2O
EC:3.4.22.55	skos:altLabel	"ICH-1"
EC:3.4.22.55	skos:altLabel	"neural precursor cell expressed developmentally down-regulated protein 2"
EC:3.4.22.55	skos:altLabel	"NEDD2 protein"
EC:3.4.22.55	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-2"
EC:3.4.22.55	skos:altLabel	"NEDD-2"
EC:3.4.22.55	skos:prefLabel	"caspase-2"
EC:3.4.22.55	skos:altLabel	"CASP-2"
REACT:R-SSC-6807206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 and OTUD3 deubiquitinate PTEN (Sus scrofa)
REACT:R-HSA-480509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of EPHA1 (Homo sapiens)
REACT:R-RNO-8933328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYPLA2 hydrolyses PALM-C3,4-GAP43 (Rattus norvegicus)
RHEA:58606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + NAD(+) => FAD + 2 H(+) + NADH + O2
REACT:R-RNO-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)
RHEA:65194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	berkeleytrione + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 2 O2 + preaustinoid A
REACT:R-CFA-2395320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 binds integrins (Canis familiaris)
RHEA:59635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylobiose + O2 <=> D-xylobiono-1,5-lactone + H2O2
REACT:R-RNO-209792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylation of serotonin (Rattus norvegicus)
RHEA:40666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine <=> 2-aminoprop-2-enoate + H2O
RHEA:21046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine => 24-methylidenelophenol + S-adenosyl-L-methionine
REACT:R-RNO-5669158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF2 binds PAK1 (Rattus norvegicus)
REACT:R-CFA-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Canis familiaris)
REACT:R-CFA-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Canis familiaris)
REACT:R-DME-870437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
REACT:R-MMU-417908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY1 binds ADP (Mus musculus)
RHEA:34431	skos:prefLabel	"(-)-lariciresinol reductase"
RHEA:34431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-lariciresinol reductase"
RHEA:34431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-secoisolariciresinol + NADP(+) = (-)-lariciresinol + H(+) + NADPH
RHEA:34431	skos:altLabel	"pinoresinol-lariciresinol reductases"
RHEA:34431	skos:altLabel	"(-)-pinoresinol-(-)-lariciresinol reductase"
RHEA:34431	skos:altLabel	"pinoresinol/lariciresinol reductase"
REACT:R-BTA-2130486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoating of clathrin-coated vesicles and fusion with endosomes (Bos taurus)
RHEA:45321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine => H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine
REACT:R-DME-5671763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates PPP1R14A (Drosophila melanogaster)
REACT:R-MMU-4615839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO2,3 (Mus musculus)
REACT:R-DRE-2454113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 transports 11cRAL to rod photoreceptor outer segment (Danio rerio)
RHEA:32482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 iodide + L-tyrosine + 2 NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH
REACT:R-HSA-9622579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter (Homo sapiens)
REACT:R-SSC-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Sus scrofa)
RHEA:41922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctadecanoyl-[ACP] + NADP(+) => 3-oxooctadecanoyl-[ACP] + H(+) + NADPH
REACT:R-XTR-165758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and inactivation of eEF2K by activated S6K1 (Xenopus tropicalis)
RHEA:17067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP
REACT:R-RNO-8863471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR is bound by DAB2 and ARH (Rattus norvegicus)
REACT:R-GGA-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Gallus gallus)
REACT:R-HSA-9014420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the phagocytic vesicle membrane (Homo sapiens)
REACT:R-RNO-5654571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS3 (Rattus norvegicus)
REACT:R-DME-5610722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI3 (Drosophila melanogaster)
RHEA:26352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-galactose 1-phosphate + H2O <=> L-galactose + phosphate
REACT:R-MMU-2395764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atREs binds to nascent CM (Mus musculus)
REACT:R-HSA-5691150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFR2 dimer binds 2xholoTF (Homo sapiens)
REACT:R-MMU-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Mus musculus)
REACT:R-SPO-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Schizosaccharomyces pombe)
RHEA:50787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + NADP(+) <=> (2E)-dodecenal + H(+) + NADPH
RHEA:39153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH
GO:0016414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-octanoyltransferase activity
REACT:R-BTA-2301205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 monomethylates histone H4 (Bos taurus)
REACT:R-XTR-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Xenopus tropicalis)
REACT:R-XTR-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Xenopus tropicalis)
REACT:R-SCE-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Saccharomyces cerevisiae)
REACT:R-SSC-8866941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MID1IP1 binds THRSP (Sus scrofa)
RHEA:45133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
REACT:R-HSA-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Homo sapiens)
RHEA:59467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octadecan-1-ol <=> H(+) + NADPH + octadecanal
REACT:R-XTR-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-BTA-5696491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNTF binds CNTFR complex (Bos taurus)
RHEA:33062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoamide + NAD(+) <=> (R)-lipoamide + H(+) + NADH
REACT:R-HSA-9036283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue (Homo sapiens)
RHEA:48858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2
REACT:R-DME-443831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3-zeta binds Raf1 (Drosophila melanogaster)
REACT:R-DME-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Drosophila melanogaster)
GO:0008733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-arabinopyranose = L-ribulose
GO:0008733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arabinose ketol-isomerase activity
GO:0008733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinose isomerase activity
GO:0008733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arabinose aldose-ketose-isomerase activity
GO:0008733	skos:prefLabel	"L-arabinose isomerase"
GO:0008733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arabinose isomerase"
GO:0051750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta5-delta2,4-dienoyl-CoA isomerase activity
GO:0051750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta3,5-delta2,4-dienoyl-CoA isomerase activity
GO:0051750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity
GO:0051750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase activity
REACT:R-HSA-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)
GO:0140792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone tyrosine phosphatase activity
RHEA:18532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol + NAD(+) <=> 3-methylbutanal + H(+) + NADH
REACT:R-SPO-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Schizosaccharomyces pombe)
RHEA:64974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + H(+) + phosphate => dUDP + H2O
RHEA:27490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-sedoheptulose 7-phosphate => D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate
RHEA:60984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoate + NAD(+) = 16-oxohexadecanoate + H(+) + NADH
REACT:R-HSA-6784791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)
RHEA:71330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-threonine(out) + 2 Na(+)(out) <=> chloride(in) + L-threonine(in) + 2 Na(+)(in)
RHEA:51894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + cadaverine => H2O + N-acetylcadaverine
GO:0031787	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H9 melatonin receptor ligand
GO:0031787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H9 melatonin receptor binding
REACT:R-MMU-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Mus musculus)
REACT:R-MMU-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Mus musculus)
RHEA:10831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + ATP + CoA <=> AMP + anthraniloyl-CoA + diphosphate
REACT:R-DME-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Drosophila melanogaster)
REACT:R-XTR-183067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Localization of CBL:GRB2 to the membrane (Xenopus tropicalis)
GO:0044604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cadystin transmembrane transporter activity
GO:0044604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytochelatin transmembrane transporter activity
GO:0044604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cadystin transporter activity
GO:0044604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent phytochelatin transmembrane transporter activity
GO:0044604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type phytochelatin transporter activity
GO:0044604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cadystin transmembrane transporter ATPase activity
GO:0044604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled phytochelatin transmembrane transporter activity
GO:0044604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytochelatin transporter activity
GO:0044604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type phytochelatin transmembrane transporter activity
GO:0044604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytochelatin transmembrane transporter ATPase activity
RHEA:62463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate
RHEA:34661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine
RHEA:64269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	emodin anthrone + O2 => emodin + H(+) + H2O
REACT:R-CEL-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
REACT:R-CEL-8848414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds CDKN1B (Caenorhabditis elegans)
REACT:R-HSA-5138459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A:FZD4 is endocytosed (Homo sapiens)
RHEA:19535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+) => 2 H(+) + 2 H2O + N(2)-succinyl-L-arginine
RHEA:66144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methoxytryptamine + acetyl-CoA = CoA + H(+) + melatonin
RHEA:53186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O
RHEA:52836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole + NADH + O2 = H2O + indoxyl + NAD(+)
REACT:R-RNO-1169403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 ligase with ISG15:E2 complex (Rattus norvegicus)
RHEA:71959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + oxaloacetate(out) = 3 Na(+)(in) + oxaloacetate(in)
GO:0050077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylpyruvate isomerase activity
GO:0050077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maleylpyruvate isomerase"
GO:0050077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-maleylpyruvate cis-trans-isomerase activity
GO:0050077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-maleylpyruvate = 3-fumarylpyruvate
GO:0050077	skos:prefLabel	"maleylpyruvate isomerase"
REACT:R-SSC-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Sus scrofa)
RHEA:68845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => (Z)-alpha-bisabolene + diphosphate
REACT:R-HSA-164507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD4:gp120  binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)
RHEA:64127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-L-phenylalanine <=> hexadecanoate + L-phenylalanine
GO:0035514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA demethylase activity
REACT:R-CFA-212005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2F1 dehydrogenates 3-methylindole (Canis familiaris)
RHEA:28536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + dTMP + H(+) => dTTP + H2O
RHEA:50131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D1 <=> 17-oxoresolvin D1 + H(+) + NADH
REACT:R-GGA-5690870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Gallus gallus)
GO:0033415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGA codon-amino acid adaptor activity
GO:0033415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGA codon-amino acid adaptor activity
RHEA:13495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH => (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+)
REACT:R-DME-5618073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Drosophila melanogaster)
REACT:R-HSA-9665032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)
REACT:R-DRE-5660662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASC binds Caspase-8 complex (Danio rerio)
REACT:R-MMU-182594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of INK4 family proteins with CDK4/6 (Mus musculus)
REACT:R-BTA-190429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c (Bos taurus)
REACT:R-MMU-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Mus musculus)
REACT:R-SPO-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)
REACT:R-SSC-430135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds ADAP (Sus scrofa)
REACT:R-BTA-169904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3G stimulates nucleotide exchange on Rap1 (Bos taurus)
REACT:R-HSA-158959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Homo sapiens)
REACT:R-HSA-8950480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of annexin A2 (Homo sapiens)
REACT:R-CFA-3371360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)
REACT:R-SSC-5625784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Sus scrofa)
GO:0030247	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	polysaccharide assembly with MHC class II protein complex
GO:0030247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polysaccharide binding
RHEA:12728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-iditol + NAD(+) <=> H(+) + keto-D-sorbose + NADH
REACT:R-CFA-5649734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates NEIL1,NEIL2-generated single strand break (Canis familiaris)
EC:1.14.11.43	skos:altLabel	"2-oxoglutarate-dependent (S)-dichlorprop dioxygenase"
EC:1.14.11.43	skos:altLabel	"(S)-phenoxypropionate/alpha-ketoglutarate-dioxygenase"
EC:1.14.11.43	skos:altLabel	"alpha-ketoglutarate-dependent (S)-dichlorprop dioxygenase"
EC:1.14.11.43	skos:altLabel	"(S)-mecoprop dioxygenase"
EC:1.14.11.43	skos:prefLabel	"(S)-dichlorprop dioxygenase (2-oxoglutarate)"
EC:1.14.11.43	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-dichlorprop dioxygenase (2-oxoglutarate)"
EC:1.14.11.43	skos:altLabel	"2-oxoglutarate-dependent (S)-mecoprop dioxygenase"
REACT:R-SPO-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Schizosaccharomyces pombe)
RHEA:28785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-cysteine => H2O + L-cysteinylglycine
RHEA:21418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 1-phosphate
REACT:R-XTR-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Xenopus tropicalis)
RHEA:55141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)
REACT:R-CEL-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Caenorhabditis elegans)
REACT:R-BTA-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Bos taurus)
REACT:R-DME-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
REACT:R-SSC-73805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Sus scrofa)
RHEA:29938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine(in) + H(+)(in) <=> cytosine(out) + H(+)(out)
RHEA:37250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thymidine 3'-monophosphate <=> phosphate + thymidine
RHEA:17477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6B + 2 S-adenosyl-L-methionine = CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine
RHEA:17477	skos:prefLabel	"precorrin-6B C(5,15)-methyltransferase (decarboxylating)"
RHEA:17477	skos:altLabel	"precorrin-6Y C(5,15)-methyltransferase (decarboxylating)"
RHEA:17477	skos:altLabel	"precorrin-6Y methylase"
RHEA:17477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"precorrin-6B C(5,15)-methyltransferase (decarboxylating)"
RHEA:17477	skos:altLabel	"precorrin-6 methyltransferase"
GO:0018695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cresol dehydrogenase (hydroxylating) activity
GO:0018695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-cresol methylhydroxylase activity
GO:0018695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-cresol-(acceptor) oxidoreductase (hydroxylating) activity
GO:0018695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-cresol:acceptor oxidoreductase (methyl-hydroxylating)
GO:0018695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cresol dehydrogenase activity
RHEA:46239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-2127257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Danio rerio)
REACT:R-HSA-4090408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate ESR1 with SUMO1 (Homo sapiens)
RHEA:29233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate(out) => cyanate(in)
RHEA:63754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carminate + 2 H(+) + UDP => kermesate + UDP-alpha-D-glucose
REACT:R-MMU-9686980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 recruits APC/C:Cdh1 complex to SKP2 (Mus musculus)
RHEA:29120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + nitrate => a ubiquinone + H2O + nitrite
REACT:R-SSC-6784861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG binds LPL dimer (Sus scrofa)
RHEA:29907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-(1'-rac-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate
REACT:R-CFA-446372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  PARVA with TESK1 (Canis familiaris)
REACT:R-BTA-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)
GO:0102985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta12-fatty-acid desaturase activity
REACT:R-CFA-8944266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XI (Canis familiaris)
REACT:R-SPO-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Schizosaccharomyces pombe)
REACT:R-HSA-2465934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL translocates from Muller cells to cone photoreceptor cells (Homo sapiens)
RHEA:18172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate
RHEA:61099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:38127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA
RHEA:42519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-gulono-1,4-lactone <=> H(+) + L-gulonate
REACT:R-CFA-445064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by VAV2 (Canis familiaris)
RHEA:40877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2 => (9Z,12Z)-octadecadienoyl-CoA + FAD + H(+)
RHEA:12328	skos:prefLabel	"1,3-alpha-oligoglucan phosphorylase"
RHEA:12328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n) + phosphate = [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate
RHEA:12328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,3-alpha-oligoglucan phosphorylase"
REACT:R-DRE-5691006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Danio rerio)
RHEA:55681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate => anthranilate + H(+) + pyruvate
REACT:R-SPO-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Schizosaccharomyces pombe)
RHEA:40311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2
REACT:R-PFA-8851538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
REACT:R-HSA-1218833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 (Homo sapiens)
REACT:R-SPO-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Schizosaccharomyces pombe)
RHEA:62890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+) => GDP-beta-L-fucose + lactose
REACT:R-BTA-6783670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1 binds CLCF1 (Bos taurus)
GO:0050579	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-deoxysarpagine:NADP+ oxidoreductase activity
GO:0050579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vellosimine dehydrogenase activity
REACT:R-HSA-400143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fatty acid ligands activate PPARA (Homo sapiens)
REACT:R-CFA-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Canis familiaris)
REACT:R-DRE-4420153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds PLCG1 (Danio rerio)
REACT:R-DDI-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Dictyostelium discoideum)
RHEA:39812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:17618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene C4 => glutathione + leukotriene A4
REACT:R-CFA-5654222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PLCG1 (Canis familiaris)
GO:0005092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-dissociation inhibitor activity
GO:0005092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDI
REACT:R-HSA-9729500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 N binds to 14-3-3 proteins (Homo sapiens)
REACT:R-HSA-210283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and PLC gamma1 (Homo sapiens)
REACT:R-XTR-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Xenopus tropicalis)
REACT:R-DRE-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Danio rerio)
RHEA:16007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate + H2O => galactarate
RHEA:26187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate
REACT:R-SSC-8937442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES3 hydrolyses CHEST to CHOL and LCFA(-) (Sus scrofa)
REACT:R-SSC-5658424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Sus scrofa)
RHEA:66289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base
REACT:R-CFA-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Canis familiaris)
RHEA:36887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O
GO:0008414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alcohol phosphotransferase activity
REACT:R-MMU-8856157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAG3 (CD233) binds MHC II (Mus musculus)
REACT:R-BTA-177923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sustained activation of SRC kinase by SHP2 (Bos taurus)
GO:0052808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP+:F420 oxidoreductase activity
GO:0052808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced coenzyme F420:NADP+ oxidoreductase activity
GO:0052808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420H2:NADP oxidoreductase activity
GO:0052808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent NADP oxidoreductase activity
GO:0052808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420H2:NADP+ oxidoreductase activity
GO:0052808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent NADP reductase activity
RHEA:70811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + sulfoacetaldehyde
RHEA:19621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)
REACT:R-CFA-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Canis familiaris)
RHEA:44470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine
REACT:R-XTR-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Xenopus tropicalis)
REACT:R-CFA-351849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Etk (Canis familiaris)
REACT:R-MMU-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Mus musculus)
RHEA:58717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + NADH + rifampicin => FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal
RHEA:47069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O
GO:0050365	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tryptophan aminopeptidase
GO:0050365	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-tryptophan aminopeptidase
GO:0050365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophanamide = L-tryptophan + NH4(+)
GO:0050365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophanamidase activity
GO:0050365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophanamidase"
GO:0050365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophanamide amidohydrolase activity
GO:0050365	skos:prefLabel	"tryptophanamidase"
RHEA:55010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + NADPH + O2
REACT:R-RNO-9033499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Rattus norvegicus)
REACT:R-HSA-5603467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C is released from PROCR (Homo sapiens)
REACT:R-DME-6797568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind CASK:Protein 4.1 (Drosophila melanogaster)
REACT:R-HSA-5665998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 binds SRF (Homo sapiens)
REACT:R-XTR-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Xenopus tropicalis)
REACT:R-CEL-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Caenorhabditis elegans)
RHEA:45855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(II)-factor III + H(+) + S-adenosyl-L-methionine <=> Co(II)-factor IV + S-adenosyl-L-homocysteine
RHEA:52615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:43213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Canis familiaris)
REACT:R-RNO-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Rattus norvegicus)
RHEA:64510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine
RHEA:68347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP <=> 3',2'-cGAMP + 2 diphosphate
RHEA:67508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine
GO:0015278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-release channel activity
GO:0015278	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	intracellular ligand-gated calcium channel activity
RHEA:54052	skos:prefLabel	"tau-cadinol synthase"
RHEA:54052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = diphosphate + tau-cadinol
RHEA:54052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tau-cadinol synthase"
REACT:R-BTA-193780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Bos taurus)
REACT:R-DRE-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Danio rerio)
RHEA:13925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine
RHEA:72165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in) => chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out)
RHEA:37824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate
RHEA:18781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malonyl-CoA decarboxylase"
RHEA:18781	skos:prefLabel	"malonyl-CoA decarboxylase"
RHEA:18781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA = acetyl-CoA + CO2
RHEA:18781	skos:altLabel	"malonyl-CoA carboxy-lyase"
RHEA:32458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone
RHEA:55248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-SSC-5686286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Sus scrofa)
REACT:R-CFA-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Canis familiaris)
REACT:R-HSA-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)
REACT:R-SSC-5683986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APBB1 and MAPK8 bind diphosphorylated H2AFX (Sus scrofa)
REACT:R-MMU-2214324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII dimerization (Mus musculus)
RHEA:18103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ethylcatechol + H(+) + NADH => cis-1,2-dihydro-3-ethylcatechol + NAD(+)
REACT:R-SPO-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Schizosaccharomyces pombe)
REACT:R-HSA-77331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Homo sapiens)
RHEA:66396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholate(in) + glutathione(in) + H2O = ADP + cholate(out) + glutathione(out) + H(+) + phosphate
GO:0018801	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pent-2-enoyl-CoA carboxy-lyase activity
GO:0018801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)
GO:0018801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaconyl-CoA decarboxylase activity
GO:0018801	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxybut-2-enoyl-CoA carboxy-lyase activity
GO:0018801	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaconyl coenzyme A decarboxylase activity
REACT:R-BTA-9677929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB inhibitors bind MAOB:FAD (Bos taurus)
REACT:R-CFA-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Canis familiaris)
REACT:R-CEL-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Caenorhabditis elegans)
REACT:R-DRE-9634850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT (Danio rerio)
REACT:R-SPO-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-SSC-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Sus scrofa)
REACT:R-SSC-216048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Sus scrofa)
RHEA:48452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA2 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine
RHEA:25029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-ribose 1''-phosphate phosphatase"
RHEA:25029	skos:altLabel	"Appr1p phosphatase"
RHEA:25029	skos:prefLabel	"ADP-ribose 1''-phosphate phosphatase"
RHEA:25029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-beta-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate
REACT:R-HSA-9670888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F9 variant is not secreted (Homo sapiens)
REACT:R-DDI-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)
REACT:R-RNO-5649873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Rattus norvegicus)
RHEA:34532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)
REACT:R-MMU-6784323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Mus musculus)
REACT:R-XTR-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Xenopus tropicalis)
RHEA:54160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate
REACT:R-CEL-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Caenorhabditis elegans)
REACT:R-BTA-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Bos taurus)
RHEA:29972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine(in) + H(+)(in) => 2'-deoxyinosine(out) + H(+)(out)
RHEA:72951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in)
REACT:R-HSA-69598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phosphorylated Cdc25A (Homo sapiens)
REACT:R-DRE-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Danio rerio)
REACT:R-SPO-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Schizosaccharomyces pombe)
RHEA:45454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine + tetradecanoate => H2O + N-tetradecanoylethanolamine
RHEA:47119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoate + glycine <=> H2O + N-eicosanoylglycinate
REACT:R-CFA-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Canis familiaris)
REACT:R-HSA-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Homo sapiens)
REACT:R-SSC-6784204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind OSMR (Sus scrofa)
RHEA:19495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + D-glucose => D-cellobiose + phosphate
REACT:R-SSC-110360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to the AP site (Sus scrofa)
REACT:R-XTR-9009910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds p-S423,S425-SMAD3 (Xenopus tropicalis)
REACT:R-GGA-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Gallus gallus)
REACT:R-MMU-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Mus musculus)
GO:0043178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol binding
RHEA:48653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:15007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A8 + succinate => 2-oxoglutarate + gibberellin A1 + O2
REACT:R-SSC-3322019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-b (Sus scrofa)
EC:3.4.21.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chymotrypsin"
EC:3.4.21.1	skos:altLabel	"alpha-chymotrypsin"
EC:3.4.21.1	skos:altLabel	"chymotrypsin A"
EC:3.4.21.1	skos:altLabel	"chymotrypsin B"
EC:3.4.21.1	skos:prefLabel	"chymotrypsin"
REACT:R-BTA-266051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HpETE is dehydrated to LTA4 by ALOX5 (Bos taurus)
REACT:R-SSC-9728150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 binds gliflozins (Sus scrofa)
GO:0033856	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxine 5-phosphate phospho lyase activity
GO:0033856	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PNP synthase activity
GO:0033856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine 5'-phosphate synthase activity
GO:0033856	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity
RHEA:47886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
REACT:R-DME-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Drosophila melanogaster)
GO:0102564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C epoxide hydrolase/isomerase activity
GO:0102564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH
REACT:R-HSA-9712081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK fusions bind FRS (Homo sapiens)
RHEA:72972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline(out) + 2 Na(+)(out) => 5-oxo-L-proline(in) + 2 Na(+)(in)
REACT:R-RNO-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Rattus norvegicus)
REACT:R-BTA-5634750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Bos taurus)
GO:1990422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxalase (glycolic acid-forming) activity
GO:0103012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferredoxin-thioredoxin reductase activity
GO:0103012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferredoxin:thioredoxin reductase activity
GO:0050437	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-endo-fenchol cyclase activity
GO:0050437	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl pyrophosphate:(-)-endo-fenchol cyclase activity
GO:0050437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-endo-fenchol synthase activity
GO:0050437	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]
RHEA:58654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifamycin SV para-naphthoquinone carboxamide => rifamycin SV ortho-naphthoquinone carboxamide
RHEA:70931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + dopamine(out) + 2 Na(+)(out) = chloride(in) + dopamine(in) + 2 Na(+)(in)
GO:0031458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type betaine transporter activity
GO:0031458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent betaine transporter activity
GO:0031458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine-transporting ATPase activity
GO:0031458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type betaine transmembrane transporter activity
GO:0031458	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	betaine ABC transporter
GO:0031458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled betaine transporter activity
REACT:R-GGA-4332236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL neddylates TGFBR2 (Gallus gallus)
RHEA:21234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + trans-urocanate => L-histidine
RHEA:57022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + apulose 4-phosphate + H(+) => apulose + ATP
RHEA:51262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Canis familiaris)
REACT:R-DRE-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Danio rerio)
REACT:R-DDI-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Dictyostelium discoideum)
RHEA:39531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)
REACT:R-HSA-400382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1E,CSNK1D phosphorylate CRY and PER proteins (Homo sapiens)
REACT:R-SPO-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Schizosaccharomyces pombe)
RHEA:57611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-chlorocatechol + H(+) + NADH
REACT:R-MMU-203156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-derived TREM-1 ligand binds to TREM-1 (Mus musculus)
RHEA:58450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine
REACT:R-DME-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Drosophila melanogaster)
REACT:R-HSA-9636669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esxA binds ENO1 (Homo sapiens)
RHEA:41980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH
REACT:R-SSC-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Sus scrofa)
REACT:R-SSC-6804379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds TTC5 (Sus scrofa)
RHEA:71822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-thyroxine(out) <=> L-thyroxine(in)
REACT:R-SCE-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Saccharomyces cerevisiae)
RHEA:49995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + propane <=> H2O + NAD(+) + propan-2-ol
REACT:R-BTA-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Bos taurus)
REACT:R-HSA-2128994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Homo sapiens)
REACT:R-DME-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Drosophila melanogaster)
REACT:R-HSA-5655240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
REACT:R-MMU-5689630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BAP1-interacting complex (Mus musculus)
REACT:R-RNO-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Rattus norvegicus)
RHEA:34516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP
REACT:R-GGA-9645428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 binds ADP-heptose (Gallus gallus)
REACT:R-HSA-909730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of INFAR1 by TYK2 (Homo sapiens)
REACT:R-RNO-376200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A10-mediated uptake of small neutral amino acids (Rattus norvegicus)
REACT:R-SPO-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Schizosaccharomyces pombe)
RHEA:10567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate 4-methyl ester <=> H(+) + methanol + oxaloacetate
RHEA:23330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis,4-trans-xanthoxin + a 12'-apo-carotenal => a 9-cis-epoxycarotenoid + O2
REACT:R-MMU-5623525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo-carrying vesicles bud from the TGN (Mus musculus)
RHEA:22349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminoimidazole + H(+) + H2O => imidazol-4-one + NH4(+)
RHEA:34307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol + NADPH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite
REACT:R-MMU-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)
RHEA:19534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 H2O + N(2)-succinyl-L-arginine => CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)
RHEA:64927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + 2 H2O <=> dAMP + 2 H(+) + 2 phosphate
RHEA:25427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + guanine
GO:1990412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hercynylselenocysteine = NH4(+) + pyruvate + selnoneine thione
GO:1990412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hercynylselenocysteine lyase activity (selenoneine-forming)
REACT:R-GGA-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Gallus gallus)
RHEA:68954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + scoparone => isoscopoletin + S-adenosyl-L-methionine
RHEA:61489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(50) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-5684261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K8 is phosphorylated (Mus musculus)
REACT:R-CFA-9015379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (compounds) binds IIa (Canis familiaris)
REACT:R-BTA-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Bos taurus)
GO:0089720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caspase binding
RHEA:69440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH
REACT:R-RNO-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Rattus norvegicus)
REACT:R-DRE-3165230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC52A1,2,3 transport RIB from extracellular region to cytosol (Danio rerio)
REACT:R-DRE-8940134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 binds FOLA (Danio rerio)
RHEA:51157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Gln)
REACT:R-CFA-5205672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncleaved Pink1 accumulates in damaged mitochondria (Canis familiaris)
REACT:R-HSA-6786155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLN binds ICL-DNA (Homo sapiens)
REACT:R-SSC-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Sus scrofa)
RHEA:63076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 2-acetylphloroglucinol + 3 CO2 + 4 CoA
RHEA:63174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-oyl-CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA
REACT:R-RNO-5626982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF binds GNB2L1 (Rattus norvegicus)
RHEA:46645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + H(+) + NADPH => 5beta-dihydrocortisol + NADP(+)
REACT:R-BTA-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Bos taurus)
REACT:R-BTA-1067676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST-2 (Bos taurus)
RHEA:64619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferol + acetyl-CoA <=> (E)-coniferyl acetate + CoA
REACT:R-DRE-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Danio rerio)
REACT:R-HSA-419334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melatonin receptors can bind melatonin (Homo sapiens)
RHEA:42158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol + NADP(+) => androsterone + H(+) + NADPH
REACT:R-RNO-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)
GO:0015398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity secondary active ammonium transmembrane transporter activity
GO:0015398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity secondary active ammonium transmembrane transporter activity
RHEA:35807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-D-arabinonate dehydratase"
RHEA:35807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O
RHEA:35807	skos:prefLabel	"2-dehydro-3-deoxy-D-arabinonate dehydratase"
RHEA:68265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formaldehyde
REACT:R-MMU-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Mus musculus)
REACT:R-RNO-2161890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Rattus norvegicus)
REACT:R-BTA-3928640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs phosphorylate MLC (Bos taurus)
REACT:R-MMU-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Mus musculus)
RHEA:38937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:19681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biotin--CoA ligase"
RHEA:19681	skos:prefLabel	"biotin--CoA ligase"
RHEA:19681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin + CoA = AMP + biotinyl-CoA + diphosphate
RHEA:19681	skos:altLabel	"biotinyl-CoA synthetase"
GO:0004023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol dehydrogenase activity, metal ion-independent
REACT:R-XTR-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Xenopus tropicalis)
REACT:R-HSA-5626227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CP110 and CEP97 dissociate from the centriole (Homo sapiens)
REACT:R-SSC-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Sus scrofa)
RHEA:34930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + selenodiglutathione <=> glutathione + glutathioselenol + NADP(+)
REACT:R-MMU-201486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand pleiotrophin (PTN) (Mus musculus)
REACT:R-RNO-5654404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds SHC1 (Rattus norvegicus)
RHEA:70919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + dopamine(out) + Na(+)(out) = chloride(in) + dopamine(in) + Na(+)(in)
RHEA:31767	skos:prefLabel	"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase"
RHEA:31767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase"
RHEA:31767	skos:altLabel	"UDP-4-dehydro-6-deoxy-D-glucose transaminase"
RHEA:31767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
RHEA:31767	skos:altLabel	"UDP-beta-L-threo-pentapyranos-4-ulose transaminase"
REACT:R-BTA-202110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1 complex binds to CaM (Bos taurus)
RHEA:69002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine => 3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine
RHEA:36018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
GO:0047057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phylloquinone epoxide reductase activity
GO:0047057	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin K1 epoxide reductase activity
GO:0047057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin-K-epoxide reductase (warfarin-sensitive) activity
REACT:R-CFA-200318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Canis familiaris)
REACT:R-XTR-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-CFA-2395784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent CMs transform into mature CMs (Canis familiaris)
RHEA:10658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + H(+) + S-adenosyl-L-homocysteine => guanidinoacetate + S-adenosyl-L-methionine
REACT:R-BTA-70355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALK1 phosphorylates Gal to Gal1P (Bos taurus)
RHEA:52414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)
REACT:R-CEL-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Caenorhabditis elegans)
RHEA:24974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:67349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-beta-D-glucoside + malonyl-CoA => apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA
REACT:R-XTR-5693153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1K dephosphorylates p-BCKDH (Xenopus tropicalis)
RHEA:12861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanosine deaminase"
RHEA:12861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + H(+) + H2O = NH4(+) + xanthosine
RHEA:12861	skos:altLabel	"guanosine aminase"
RHEA:12861	skos:prefLabel	"guanosine deaminase"
REACT:R-RNO-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Rattus norvegicus)
RHEA:13037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + H2O = ITP + NH4(+)
RHEA:19921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + H(+) + NADPH
REACT:R-GGA-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Gallus gallus)
RHEA:10688	skos:prefLabel	"streptomycin-6-phosphatase"
RHEA:10688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"streptomycin-6-phosphatase"
RHEA:10688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + streptomycin 6-phosphate = phosphate + streptomycin
REACT:R-CFA-9692376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL2 binds BCL2 antagonists (Canis familiaris)
REACT:R-MMU-5687088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates MAPKAPK5 (Mus musculus)
REACT:R-HSA-5686475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Homo sapiens)
RHEA:41164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-amino-sn-glycerol + ATP => 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)
RHEA:11043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
RHEA:71140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH => 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)
RHEA:11089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trimetaphosphate => 2 H(+) + triphosphate
REACT:R-XTR-2130725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of MHC II:Ii clathrin coated vesicle (Xenopus tropicalis)
RHEA:48355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
REACT:R-DME-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Drosophila melanogaster)
REACT:R-RNO-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Rattus norvegicus)
REACT:R-BTA-6797653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMGDH:FAD oxidatively demethylates DMGLY to SARC (Bos taurus)
RHEA:20875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rb1 + H(+) + UDP
RHEA:47819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)
RHEA:43697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate => diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]
RHEA:41497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-SSC-5666088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP recruits DAIPH2-3 to endosomes (Sus scrofa)
RHEA:66897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]
RHEA:57068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate + ATP = 3-oxoisoapionate 4-phosphate + ADP + H(+)
RHEA:57068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxoisoapionate kinase"
RHEA:57068	skos:prefLabel	"3-oxoisoapionate kinase"
REACT:R-CEL-5205682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin promotes the ubiquitination of mitochondrial substrates (Caenorhabditis elegans)
RHEA:43429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycerol + ATP => 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DRE-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Danio rerio)
REACT:R-CEL-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Caenorhabditis elegans)
REACT:R-DME-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Drosophila melanogaster)
REACT:R-DRE-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Danio rerio)
RHEA:61042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:31149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxymandelaldehyde + H(+) + NADH => 3,4-dihydroxyphenylethyleneglycol + NAD(+)
RHEA:30028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + H(+) + NADH => glycerol + NAD(+)
REACT:R-DME-352232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Drosophila melanogaster)
RHEA:68249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine(in) + Na(+)(in) => L-tyrosine(out) + Na(+)(out)
REACT:R-SSC-2161745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Sus scrofa)
REACT:R-CFA-749452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
GO:0034320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol O-hexanoyltransferase activity
RHEA:72365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + hydrogencarbonate(out) => chloride(out) + hydrogencarbonate(in)
REACT:R-CFA-192051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7A1 7-hydroxylates CHOL (Canis familiaris)
REACT:R-HSA-5621355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Homo sapiens)
RHEA:39040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-oxo fatty acid + H2O + NAD(+) => a dicarboxylate + 2 H(+) + NADH
RHEA:66570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	preluffariellolide A => (2E,6E,10E,14E)-geranylfarnesol + H2O
RHEA:36037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+)
RHEA:66933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate => avenanthramide A + CoA
RHEA:69208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate
GO:1990439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP kinase serine/threonine phosphatase activity
REACT:R-BTA-5693593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop extension by DNA polymerases (Bos taurus)
REACT:R-GGA-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)
REACT:R-HSA-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Homo sapiens)
REACT:R-DRE-9029566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Danio rerio)
RHEA:68728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 <=> (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2
RHEA:44261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA
REACT:R-SSC-6805205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR35 binds kynurenic acid (Sus scrofa)
REACT:R-DME-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Drosophila melanogaster)
REACT:R-XTR-202291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Lck (Xenopus tropicalis)
REACT:R-SSC-9656893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1MW binds 11cRAL (Sus scrofa)
RHEA:16673	skos:prefLabel	"phosphonopyruvate hydrolase"
RHEA:16673	skos:altLabel	"PPH"
RHEA:16673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphonopyruvate + H2O = H(+) + phosphate + pyruvate
RHEA:16673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphonopyruvate hydrolase"
REACT:R-MMU-6785986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases unhook the interstrand crosslink (ICL) (Mus musculus)
REACT:R-DME-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Drosophila melanogaster)
RHEA:13035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagatose 6-phosphate => aldehydo-D-galactose 6-phosphate
REACT:R-RNO-8865454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX3 (Rattus norvegicus)
REACT:R-HSA-9634429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK (Homo sapiens)
REACT:R-CFA-5368596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Canis familiaris)
RHEA:73001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide] => H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide]
RHEA:12982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + S-sulfanylglutathione => glutathione + 2 H(+) + sulfite
RHEA:49749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NADP(+) + proviolacein
REACT:R-SPO-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Schizosaccharomyces pombe)
REACT:R-HSA-2032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ), TBX5, and PCAF form a complex (Homo sapiens)
REACT:R-BTA-6811479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 recruits EP300 to TP53 (Bos taurus)
RHEA:47019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O <=> [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite
GO:0050168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pentanamide amidohydrolase activity
GO:0050168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentanamidase activity
GO:0050168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valeramidase activity
GO:0018824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HAB mutase activity
GO:0018824	skos:prefLabel	"(hydroxyamino)benzene mutase"
GO:0018824	skos:altLabel	"HAB mutase"
GO:0018824	skos:altLabel	"hydroxylaminobenzene mutase"
GO:0018824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(hydroxyamino)benzene hydroxymutase activity
GO:0018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-phenylhydroxylamine = 2-aminophenol
GO:0018824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylaminobenzene hydroxymutase activity
GO:0018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(hydroxyamino)benzene mutase activity
GO:0018824	skos:altLabel	"hydroxylaminobenzene hydroxymutase"
GO:0018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(hydroxyamino)benzene mutase"
GO:0018824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylaminobenzene mutase activity
REACT:R-RNO-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Rattus norvegicus)
REACT:R-SSC-5684865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB dimer,C translocate from multivesicle body to lamellar body (Sus scrofa)
RHEA:30795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + CoA + NAD(+) = CO2 + glutaryl-CoA + NADH
RHEA:41684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)
GO:0047510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mesaconate mesaconase activity
GO:0047510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-methylmalate hydro-lyase activity
GO:0047510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mesaconase activity
GO:0047510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylmalate dehydratase activity
GO:0047510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-citramalate hydrolase activity
GO:0047510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)
GO:0047510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-citramalic hydro-lyase activity
GO:0047510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citramalate dehydratase activity
GO:0047510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-citramalate hydro-lyase activity
GO:0047510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mesaconate hydratase activity
REACT:R-DRE-373750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:ErbB2 (Danio rerio)
REACT:R-DME-176609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + PAPS => cholesterol sulfate + PAP (Drosophila melanogaster)
RHEA:47168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH
RHEA:16856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(1,2-dicarboxyethyl)-AMP <=> AMP + fumarate
REACT:R-MMU-9006873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT binding (Mus musculus)
REACT:R-HSA-2161949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH (Homo sapiens)
REACT:R-CEL-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Caenorhabditis elegans)
REACT:R-XTR-2731141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds fibronectin (Xenopus tropicalis)
REACT:R-MMU-419428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR2-5 bind S1P (Mus musculus)
REACT:R-HSA-444691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prokineticin receptors bind prokineticin (Homo sapiens)
RHEA:40663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine = 2-aminoprop-2-enoate + H2O
REACT:R-RNO-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Rattus norvegicus)
REACT:R-RNO-191763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP:Snurportin complex formation (Rattus norvegicus)
REACT:R-CEL-174367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)
GO:0015654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tellurite transmembrane transporter activity
GO:0015654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tellurite uptake transmembrane transporter activity
GO:0015654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tellurite-resistance uptake transmembrane transporter activity
GO:0015654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tellurite-resistance uptake permease activity
REACT:R-RNO-5362437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are bound by lectins (Rattus norvegicus)
REACT:R-SSC-3266566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Sus scrofa)
REACT:R-HSA-5228521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Homo sapiens)
GO:0005243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	connexin
GO:0005243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	innexin channel activity
GO:0005243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity
GO:0005243	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	innexin
GO:0005243	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	intercellular channel
REACT:R-DRE-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Danio rerio)
GO:0106350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octaprenyl pyrophosphate synthase activity
RHEA:36211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate
RHEA:32451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate
REACT:R-DME-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Drosophila melanogaster)
REACT:R-HSA-9008177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds HEY1,HEY2,HES1 (Homo sapiens)
REACT:R-SSC-176175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Stalling of DNA replication fork and RPA binding (Sus scrofa)
REACT:R-DRE-8879117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT2 transfers GlcNAc to Man-DAG1 (Danio rerio)
GO:0140375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	immune receptor activity
REACT:R-SSC-5333671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCAs self cleave (Sus scrofa)
REACT:R-HSA-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Homo sapiens)
GO:0052749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose-6-phosphate:F420 1-oxidoreductase activity
GO:0052749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme F420-dependent glucose-6-phosphate dehydrogenase activity
GO:0052749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-6-phosphate dehydrogenase (coenzyme F420) activity
GO:0052749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	F420-dependent glucose-6-phosphate dehydrogenase activity
REACT:R-CEL-8858500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC10A binds Tn-MUC1 (Caenorhabditis elegans)
RHEA:72908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(out) + Na(+)(out) => D-mannose(in) + Na(+)(in)
RHEA:59445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A => 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2
RHEA:30113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-enterobactin + H(+) + 3 H2O
REACT:R-CFA-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Canis familiaris)
REACT:R-DRE-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Danio rerio)
REACT:R-HSA-450074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)
REACT:R-HSA-9012657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Homo sapiens)
REACT:R-HSA-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)
GO:0102290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin monooxygenase activity
REACT:R-CFA-111746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Canis familiaris)
REACT:R-CFA-1678650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses Heparan sulfate chain(5) (Canis familiaris)
GO:0050153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	w-hydroxydecanoate dehydrogenase activity
GO:0050153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-hydroxydecanoate:NAD+ 10-oxidoreductase activity
GO:0050153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	omega-hydroxydecanoate dehydrogenase activity
RHEA:72438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-AMP + CoA <=> (E)-caffeoyl-CoA + AMP + H(+)
REACT:R-DRE-1236956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfment of particulate antigen into phagocytic vesicle (Danio rerio)
REACT:R-HSA-3221982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANP binds TP53 (Homo sapiens)
REACT:R-DRE-749454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gi complex dissociates (Danio rerio)
REACT:R-DME-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Drosophila melanogaster)
RHEA:29429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + 4-(trimethylamino)butanoate(out) => (R)-carnitine(out) + 4-(trimethylamino)butanoate(in)
RHEA:16114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) => 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH
REACT:R-SSC-5649673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyA from damaged DNA (Sus scrofa)
REACT:R-SCE-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Saccharomyces cerevisiae)
RHEA:32501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,3R,5S)-sabinol + H2O + NADP(+) => (1R,5R)-sabinene + H(+) + NADPH + O2
REACT:R-SSC-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)
REACT:R-DDI-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Dictyostelium discoideum)
RHEA:20550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + 2 thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate
RHEA:39661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine
RHEA:61283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + H2O + O2 <=> H2O2 + NH4(+) + succinate semialdehyde
REACT:R-DRE-3296233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T2Rs bind bitter-tasting compounds (Danio rerio)
REACT:R-HSA-2023462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers (Homo sapiens)
REACT:R-XTR-1482887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Xenopus tropicalis)
RHEA:18893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonol-3-O-glucoside glucosyltransferase"
RHEA:18893	skos:prefLabel	"flavonol-3-O-glucoside glucosyltransferase"
RHEA:18893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP
RHEA:28228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-6786650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDHD1,2 hydrolyse PA (Xenopus tropicalis)
EC:1.3.1.43	skos:altLabel	"arogenic dehydrogenase"
EC:1.3.1.43	skos:altLabel	"L-arogenate:NAD(+) oxidoreductase"
EC:1.3.1.43	skos:altLabel	"cyclohexadienyl dehydrogenase"
EC:1.3.1.43	skos:prefLabel	"arogenate dehydrogenase"
EC:1.3.1.43	skos:altLabel	"pretyrosine dehydrogenase"
EC:1.3.1.43	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arogenate dehydrogenase"
RHEA:60076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 = 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)
REACT:R-SPO-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Schizosaccharomyces pombe)
RHEA:57542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+) => a 5'-end NTP-ribonucleotide-RNA + H2O
RHEA:31393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diapolycopene + 4 FADH2 => 15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+)
GO:0042834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan binding
RHEA:25528	skos:altLabel	"SHIP"
RHEA:25528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
RHEA:25528	skos:prefLabel	"phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase"
RHEA:25528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase"
REACT:R-MMU-2309787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS2 (Mus musculus)
RHEA:45760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-daunosamine + epsilon-rhodomycinone = dTDP + H(+) + rhodomycin D
REACT:R-XTR-379382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates DA to DOPAC (Xenopus tropicalis)
REACT:R-HSA-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Homo sapiens)
RHEA:60697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lavandulyl diphosphate + H2O => (R)-lavandulol + diphosphate
REACT:R-HSA-109822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Homo sapiens)
REACT:R-HSA-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Homo sapiens)
REACT:R-XTR-1297338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of ADAM and B4GALT1 With ZP3 (Xenopus tropicalis)
REACT:R-HSA-3371360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
REACT:R-SSC-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Sus scrofa)
RHEA:66546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-adenosyl-L-methionine
RHEA:34481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate
REACT:R-HSA-5602624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective TRAF3 does not transmit the signal (Homo sapiens)
RHEA:35765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-5690042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)
REACT:R-HSA-8851011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 polyubiquitinates PTEN (Homo sapiens)
REACT:R-CFA-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Canis familiaris)
REACT:R-CEL-4719436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO1 (Caenorhabditis elegans)
REACT:R-SSC-5218826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Sus scrofa)
REACT:R-SPO-6791219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Schizosaccharomyces pombe)
REACT:R-RNO-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Rattus norvegicus)
REACT:R-HSA-8874187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L2 (Homo sapiens)
GO:0043838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	EptB
GO:0043838	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphoethanolamine transferase
GO:0043838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity
RHEA:43029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteate => 2-aminoprop-2-enoate + H(+) + sulfite
RHEA:49341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:47678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate => ATP + N-acetyl-D-galactosamine
RHEA:46319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)
REACT:R-XTR-5621363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Xenopus tropicalis)
REACT:R-DME-9610750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Drosophila melanogaster)
RHEA:61083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-minovincinine + acetyl-CoA <=> (+)-echitovenine + CoA
RHEA:25614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => terpentedienyl diphosphate
GO:0034188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein A-I receptor activity
REACT:R-CFA-391168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP gamma binds CD47 (Canis familiaris)
REACT:R-CFA-5229203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates histone H2A arginine-30 (H2AR29) (Canis familiaris)
RHEA:29459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out)
REACT:R-HSA-5687484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)
RHEA:17364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-3-ureidopropanoate + H2O <=> H(+) + malonate + urea
REACT:R-HSA-444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR5 binds CXCL13 (Homo sapiens)
REACT:R-HSA-9725357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM-ALK-dependent CEBPB gene expression (Homo sapiens)
REACT:R-DRE-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Danio rerio)
RHEA:22555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + an alcohol <=> adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)
RHEA:44305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA => a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-SSC-3858489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds DAAM1 (Sus scrofa)
RHEA:15461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)
RHEA:11818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate => alpha-D-glucose 6-phosphate
REACT:R-SSC-380905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serotonin loaded synaptic vesicle docking and priming (Sus scrofa)
RHEA:69616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-XTR-9640168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Xenopus tropicalis)
RHEA:28351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-beta-L-arabinofuranose => UDP-beta-L-arabinopyranose
RHEA:51960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylpropanal oxime = 2-methylpropanenitrile + H2O
REACT:R-MMU-180047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates DARPP-32 on Thr75 (Mus musculus)
REACT:R-RNO-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Rattus norvegicus)
REACT:R-DRE-73805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Danio rerio)
REACT:R-CEL-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Caenorhabditis elegans)
RHEA:45633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
RHEA:17196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate
RHEA:55809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-BTA-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Bos taurus)
REACT:R-DME-9021050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 oligomer binds ESRs (Drosophila melanogaster)
REACT:R-DME-214871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated CACT is degraded in the cytosol (Drosophila melanogaster)
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-N-acetylglucosaminidase F activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-N-acetylglucosaminidase D activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-N-acetylglucosaminidase H activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-acetylglucosaminidase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoglycosidase S activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-N-acetyl-beta-glucosaminidase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-N-acetylglucosaminidase L activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-N-acetylglucosaminidase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-N-acetyl-beta-D-glucosaminidase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoglycosidase H activity
GO:0033925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-(1->4)-N-acetylglucosaminidase activity
REACT:R-CEL-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Caenorhabditis elegans)
REACT:R-CFA-177157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Canis familiaris)
REACT:R-GGA-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
REACT:R-HSA-210289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-DAP12 (Homo sapiens)
RHEA:20574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-937029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Sus scrofa)
REACT:R-HSA-5578783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Homo sapiens)
RHEA:68108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glucitol + NAD(+) = H(+) + keto-L-fructose + NADH
RHEA:36249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + trans-anethole => S-adenosyl-L-methionine + trans-anol
RHEA:71601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + maleate(out) => 2-oxoglutarate(out) + maleate(in)
REACT:R-HSA-380176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)
RHEA:10999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanal oxime + S-adenosyl-L-methionine <=> 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine
RHEA:60611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine
REACT:R-SCE-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Saccharomyces cerevisiae)
REACT:R-XTR-8851899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Xenopus tropicalis)
RHEA:25308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-phosphate + H2O => 7,8-dihydroneopterin + phosphate
RHEA:19868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + uroporphyrinogen III <=> 4 CO2 + coproporphyrinogen III
REACT:R-HSA-198295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRKA phosphorylates IRS (Homo sapiens)
REACT:R-PFA-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Plasmodium falciparum)
REACT:R-SSC-2995376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Sus scrofa)
RHEA:47695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + neomycin C + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B
GO:0015103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic anion transmembrane transporter activity
REACT:R-BTA-391942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP receptor can bind prostacyclin (Bos taurus)
REACT:R-RNO-9634861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT2 (Rattus norvegicus)
RHEA:16677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetaldehyde + H2O + NAD(+) = fluoroacetate + 2 H(+) + NADH
RHEA:16677	skos:prefLabel	"fluoroacetaldehyde dehydrogenase"
RHEA:16677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fluoroacetaldehyde dehydrogenase"
REACT:R-DDI-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Dictyostelium discoideum)
REACT:R-HSA-9635446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rv3654c binds SFPQ (Homo sapiens)
RHEA:46013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + a quinone => a quinol + oxaloacetate
REACT:R-HSA-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Homo sapiens)
RHEA:59804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine = D-phenylalanine
RHEA:43890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine => [sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine
REACT:R-GGA-9697750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8:FLIP(L) (Gallus gallus)
RHEA:11018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + urea => allantoate + H2O
RHEA:47550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-4,6-dien-24-oate + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oate
REACT:R-HSA-8870703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 (MnSOD) gene expression (Homo sapiens)
REACT:R-XTR-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Xenopus tropicalis)
REACT:R-HSA-3788075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by ADAMTS4, ADAMTS5 (Homo sapiens)
REACT:R-CFA-390641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA1A,B,D bind ADR,NAd (Canis familiaris)
REACT:R-BTA-2064421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds ZO-2 (TJP2) (Bos taurus)
REACT:R-HSA-8982162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Homo sapiens)
REACT:R-DME-450550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCalpha phosphorylates HuR (Drosophila melanogaster)
REACT:R-PFA-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Plasmodium falciparum)
REACT:R-RNO-9613264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Rattus norvegicus)
RHEA:67079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-BTA-168915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Bos taurus)
RHEA:58414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin] => 3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-SSC-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Sus scrofa)
REACT:R-CFA-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Canis familiaris)
REACT:R-XTR-173631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1s (Xenopus tropicalis)
RHEA:51010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+) => 2 Fe(III)-[cytochrome cL] + methanol
REACT:R-RNO-5651657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)
RHEA:10525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) => CO2 + succinate semialdehyde
RHEA:26128	skos:prefLabel	"isopimara-7,15-diene synthase"
RHEA:26128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate = diphosphate + isopimara-7,15-diene
RHEA:26128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopimara-7,15-diene synthase"
REACT:R-XTR-448744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20RA binds IL20RB (Xenopus tropicalis)
RHEA:10251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O <=> diphosphate + dUMP + H(+)
REACT:R-DRE-8987202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Danio rerio)
REACT:R-CEL-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Caenorhabditis elegans)
RHEA:16707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + H(+) + NADPH => 17alpha-estradiol + NADP(+)
REACT:R-CFA-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Canis familiaris)
REACT:R-MMU-202248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma1 (Mus musculus)
RHEA:44684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine
REACT:R-BTA-9701000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1:BARD1 heterodimer autoubiquitinates (Bos taurus)
REACT:R-CEL-199910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates ATF1 (Caenorhabditis elegans)
REACT:R-BTA-216045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I binds integrin alpha11beta1 (Bos taurus)
REACT:R-HSA-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Homo sapiens)
RHEA:55196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal
REACT:R-CFA-1067676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST-2 (Canis familiaris)
REACT:R-HSA-5210918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pagA binds ANTXR2 (Homo sapiens)
RHEA:13091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite => 6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+)
REACT:R-DRE-2130282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated beta catenin by the proteasome (Danio rerio)
REACT:R-SSC-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Sus scrofa)
REACT:R-HSA-399931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Fyn (Homo sapiens)
GO:0052726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ins(1,3,4)P(3) 5-kinase activity
GO:0052726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4-trisphosphate 5-kinase activity
GO:0052726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,3,4-trisphosphate 5-kinase activity
GO:0052726	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1D-myo-inositol-trisphosphate 5-kinase activity
GO:0052726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ins(1,3,4)P3 5-kinase activity
GO:0052726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity
GO:0052726	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	IP3 5-kinase activity
GO:0052726	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol-trisphosphate 5-kinase activity
REACT:R-DME-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Drosophila melanogaster)
REACT:R-CFA-203567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylation of eNOS (Canis familiaris)
REACT:R-GGA-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Gallus gallus)
RHEA:50457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H3 => prostaglandin D3
REACT:R-MMU-917891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Mus musculus)
RHEA:72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)
REACT:R-RNO-909732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT2 (Rattus norvegicus)
RHEA:62391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n) + H2O <=> [(1->2)-beta-D-glucosyl](n-2) + sophorose
REACT:R-MMU-382055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb7 binds to the active PDGF receptor (Mus musculus)
REACT:R-CEL-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)
RHEA:27710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanosine = ADP + GMP + H(+)
REACT:R-BTA-6785126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA core complex assembles at DNA interstrand crosslinks (ICLs) (Bos taurus)
GO:0018727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenanthrol sulphotransferase activity
GO:0018727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenanthrol sulfotransferase activity
REACT:R-DRE-6786239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
RHEA:56951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + UTP <=> H(+) + phosphoenolpyruvate + UDP
REACT:R-CEL-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Caenorhabditis elegans)
REACT:R-BTA-378975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follitropin is a heterodimer (Bos taurus)
RHEA:28304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + germacrene C => (2E,6E)-farnesyl diphosphate
GO:0102632	skos:prefLabel	"(S)-nandinine synthase"
GO:0102632	skos:altLabel	"CYP719A3"
GO:0102632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-nandinine synthase"
GO:0102632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nandinine synthase activity
REACT:R-XTR-5336182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37 binds prosaptide (Xenopus tropicalis)
REACT:R-DDI-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Dictyostelium discoideum)
REACT:R-SSC-2314678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS1 (Sus scrofa)
RHEA:68997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A9 + O2 => CO2 + gibberellin A4 + succinate
REACT:R-HSA-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Homo sapiens)
RHEA:23693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate => H2O + maleate
RHEA:43923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-8952062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 recruits HDAC4 to RUNX3 (Homo sapiens)
REACT:R-XTR-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Xenopus tropicalis)
REACT:R-SSC-8950778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dimerizes (Sus scrofa)
RHEA:70448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 => a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate
REACT:R-GGA-5634100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 dissociates from RXRA:PPARD:atRA (Gallus gallus)
REACT:R-CFA-141139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of TRAIL:TRAIL receptor complex (Canis familiaris)
REACT:R-SSC-3371360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)
REACT:R-DDI-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Dictyostelium discoideum)
REACT:R-SCE-8851550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)
REACT:R-BTA-380316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of NuMA with microtubules (Bos taurus)
RHEA:39060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-443779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Linkage of L1 with treadmilling F-actin (Xenopus tropicalis)
REACT:R-RNO-193060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)
REACT:R-RNO-1504186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL recruits GSK3beta:AXIN1 to the receptor complex (Rattus norvegicus)
RHEA:37694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
RHEA:49361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',2'-dihydroxy-2-oxospirilloxanthin => 2,2'-dioxospirilloxanthin + H2O
GO:0015478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharide transporting porin activity
GO:0015478	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	raffinose porin
REACT:R-HSA-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Homo sapiens)
RHEA:69598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + IMP => AMP + inosine
RHEA:35794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin X + UDP
REACT:R-GGA-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Gallus gallus)
REACT:R-BTA-380303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Phospho-Nlp from the centrosome (Bos taurus)
RHEA:58172	skos:prefLabel	"beta-pinacene synthase"
RHEA:58172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-pinacene synthase"
RHEA:58172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = beta-pinacene + diphosphate
GO:0019767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE receptor activity
REACT:R-XTR-9706399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 hydrolyzes ATP (Xenopus tropicalis)
REACT:R-RNO-8863101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPPL2a/b cleaves TNF(1-76) (Rattus norvegicus)
REACT:R-RNO-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Rattus norvegicus)
REACT:R-BTA-1855163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Bos taurus)
RHEA:49559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] <=> H(+) + L-cysteinyl-[protein] + lactate
RHEA:17143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-aspartate => glycine + oxaloacetate
RHEA:57012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H2O + sulfite = a menaquinol + sulfate
REACT:R-DME-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Drosophila melanogaster)
REACT:R-DME-432607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRI replaces PDP1 as binder to Clk and cry genes (Drosophila melanogaster)
REACT:R-RNO-70555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Rattus norvegicus)
REACT:R-DRE-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Danio rerio)
REACT:R-CEL-212710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR activates PLC-gamma1 by phosphorylation (Caenorhabditis elegans)
RHEA:18451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + arsenate + H(+) => A + arsenite + H2O
REACT:R-CEL-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Caenorhabditis elegans)
REACT:R-GGA-5682010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10:ATG12 binds ATG5 (Gallus gallus)
REACT:R-HSA-9709366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO translocates from cytosol to mitochondrial inner membrane (Homo sapiens)
GO:0050580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)"
GO:0050580	skos:altLabel	"2,5-diketo-D-gluconate reductase"
GO:0050580	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-diketo-D-gluconate reductase activity
GO:0050580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-didehydrogluconate reductase activity
GO:0050580	skos:prefLabel	"2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)"
GO:0050580	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	YqhE reductase
GO:0050580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH
GO:0050580	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity
REACT:R-HSA-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Homo sapiens)
REACT:R-HSA-2272795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and KIR2DS1 (Homo sapiens)
RHEA:25525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => 9alpha-copalyl diphosphate
GO:0047342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose-1-phosphate thymidylyltransferase activity
GO:0047342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity
GO:0047342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose 1-phosphate thymidylyl transferase activity
GO:0047342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP galactose pyrophosphorylase activity
GO:0047342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphosphogalactose pyrophosphorylase activity
GO:0047342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-galactose diphosphorylase activity
GO:0047342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity
GO:0047342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-galactose pyrophosphorylase activity
RHEA:53194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O
REACT:R-XTR-5218851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Xenopus tropicalis)
REACT:R-BTA-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)
RHEA:25794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Cu(+)(out) + H(+) + phosphate => ATP + Cu(+)(in) + H2O
RHEA:47004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate
REACT:R-DME-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Drosophila melanogaster)
REACT:R-DME-5667008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds RHPN1 or RHPN2 (Drosophila melanogaster)
REACT:R-BTA-3000411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates PML with SUMO2 (Bos taurus)
REACT:R-MMU-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Mus musculus)
REACT:R-CFA-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Canis familiaris)
GO:0050581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol oxidase activity
GO:0050581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannitol:oxygen oxidoreductase (cyclizing)
GO:0050581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannitol oxidase activity
GO:0050581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabitol oxidase activity
GO:0050581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinitol oxidase activity
REACT:R-MMU-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Mus musculus)
REACT:R-SSC-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Sus scrofa)
EC:1.1.1.286	skos:prefLabel	"isocitrate--homoisocitrate dehydrogenase"
EC:1.1.1.286	skos:altLabel	"homoisocitrate--isocitrate dehydrogenase"
EC:1.1.1.286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isocitrate--homoisocitrate dehydrogenase"
RHEA:68059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O <=> a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)
GO:0103003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleate peroxygenase activity
REACT:R-SSC-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Sus scrofa)
REACT:R-SSC-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Sus scrofa)
RHEA:12622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate => CO2 + L-alanine
RHEA:22512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"precorrin-8X methylmutase"
RHEA:22512	skos:altLabel	"hydrogenobyrinic acid-binding protein"
RHEA:22512	skos:altLabel	"precorrin isomerase"
RHEA:22512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + precorrin-8X = hydrogenobyrinate
RHEA:22512	skos:prefLabel	"precorrin-8X methylmutase"
RHEA:22512	skos:altLabel	"HBA synthase"
RHEA:15421	skos:altLabel	"fatty acid thiokinase (long chain)"
RHEA:15421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-fatty-acid--CoA ligase"
RHEA:15421	skos:altLabel	"lignoceroyl-CoA synthase"
RHEA:15421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate
RHEA:15421	skos:altLabel	"acyl-activating enzyme"
RHEA:15421	skos:altLabel	"acyl-CoA synthetase"
RHEA:15421	skos:prefLabel	"long-chain-fatty-acid--CoA ligase"
REACT:R-XTR-9620515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2B,EP300 acetylate FOXO3 under oxidative stress (Xenopus tropicalis)
REACT:R-DRE-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Danio rerio)
RHEA:29597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + sulfoacetyl-CoA => CoA + NADP(+) + sulfoacetaldehyde
REACT:R-GGA-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Gallus gallus)
RHEA:24011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hypotaurocyamine <=> ADP + H(+) + N(omega)-phosphohypotaurocyamine
REACT:R-SSC-8855564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Sus scrofa)
REACT:R-CFA-204861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shc1 (Canis familiaris)
RHEA:56761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:55862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Xenopus tropicalis)
REACT:R-HSA-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
REACT:R-MMU-9726949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIR binds PTGIR agonists (Mus musculus)
GO:0018634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene monooxygenase [NADH] activity
REACT:R-DME-432520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLK:CYC heterodimer binds to cwo gene and activates transcription (Drosophila melanogaster)
GO:0016818	skos:prefLabel	"In phosphorus-containing anhydrides"
GO:0016818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In phosphorus-containing anhydrides"
GO:0016818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
REACT:R-HSA-5218852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds PI3K (Homo sapiens)
REACT:R-CEL-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Caenorhabditis elegans)
RHEA:45711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnitine + acetyl-CoA <=> 3-dehydrocarnityl-CoA + acetate
RHEA:59791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH
REACT:R-HSA-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Homo sapiens)
REACT:R-MMU-8941312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Mus musculus)
RHEA:16748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + phylloquinone <=> 2,3-epoxyphylloquinone + A + H2O
REACT:R-GGA-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Gallus gallus)
GO:0051082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimmed spike protein binds to calnexin (Homo sapiens)
GO:0051082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	unfolded protein binding
GO:0051082	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chaperone activity
RHEA:42481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)
REACT:R-RNO-3215310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)
REACT:R-CEL-549304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal clearance of organic cations (Caenorhabditis elegans)
RHEA:34883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + selenate(out) = ADP + H(+) + phosphate + selenate(in)
RHEA:22371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose 5-phosphate <=> D-xylulose 5-phosphate
REACT:R-BTA-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)
REACT:R-BTA-2022073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen triple helix formation (Bos taurus)
RHEA:35932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP
REACT:R-DRE-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Danio rerio)
RHEA:11076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 3 H(+) + NADH + O2 = catechol + CO2 + NAD(+) + NH4(+)
REACT:R-CEL-8849102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRMS phosphorylates PTK6 (Caenorhabditis elegans)
REACT:R-HSA-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Homo sapiens)
REACT:R-MMU-6804762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 forms homotetramers (Mus musculus)
REACT:R-RNO-5333051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA1 binds HSF1 (Rattus norvegicus)
REACT:R-DME-430347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MigFilin associates with Filamin and F-actin (Drosophila melanogaster)
RHEA:69144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O + O2 = 4-guanidinobutanal + H2O2 + NH4(+)
RHEA:64556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = 8-epi-ilicicolin H
REACT:R-GGA-205289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of KIT (Gallus gallus)
RHEA:13389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]
RHEA:13389	skos:prefLabel	"glutaryl-CoA dehydrogenase (ETF)"
RHEA:13389	skos:altLabel	"glutaryl-CoA dehydrogenase"
RHEA:13389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutaryl-CoA dehydrogenase (ETF)"
RHEA:33542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosteryl ester + H2O <=> a carboxylate + ergosterol + H(+)
REACT:R-BTA-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Bos taurus)
RHEA:68089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] => a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]
RHEA:58170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-5-epi-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-SSC-6806647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)
REACT:R-BTA-375340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 62 mediated neuronal gap junction communication (Bos taurus)
GO:0018024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity
GO:0018024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity
GO:0018024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-lysine N-methyltransferase activity
GO:0018024	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity
GO:0018024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-methyltransferase activity
GO:0018024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-lysine N-methylase activity
REACT:R-CFA-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Canis familiaris)
REACT:R-CEL-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Caenorhabditis elegans)
REACT:R-PFA-110354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of OGG1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)
REACT:R-SSC-5662692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is oxidized to dopaquinone by TYR (Sus scrofa)
REACT:R-DRE-210277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-1 (Danio rerio)
RHEA:24504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acireductone dioxygenase (Fe(2+)-requiring)"
RHEA:24504	skos:altLabel	"E-2'"
RHEA:24504	skos:altLabel	"ARD'"
RHEA:24504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
RHEA:24504	skos:altLabel	"acireductone dioxygenase"
RHEA:24504	skos:prefLabel	"acireductone dioxygenase (Fe(2+)-requiring)"
RHEA:24504	skos:altLabel	"2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase"
REACT:R-HSA-4420128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates SHB (Homo sapiens)
REACT:R-HSA-994140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Homo sapiens)
REACT:R-MMU-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Mus musculus)
REACT:R-RNO-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Rattus norvegicus)
RHEA:32132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2
RHEA:28950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-arabinose(in) <=> H(+)(in) + L-arabinose(out)
REACT:R-HSA-9017983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds CRH gene promoter (Homo sapiens)
REACT:R-DME-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Drosophila melanogaster)
RHEA:71213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorate(in) + 2 Na(+)(in) => chlorate(out) + 2 Na(+)(out)
REACT:R-CFA-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)
REACT:R-DRE-9629918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 translocates to the nucleus (Danio rerio)
REACT:R-XTR-5626981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Xenopus tropicalis)
REACT:R-HSA-2213243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of COPII vesicle with Golgi complex (Homo sapiens)
REACT:R-CEL-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Caenorhabditis elegans)
REACT:R-CFA-422048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acyl Ghrelin and C-Ghrelin are secreted (Canis familiaris)
REACT:R-HSA-5686073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-3Y-SHC1 (Homo sapiens)
REACT:R-HSA-193702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of the ICD migrates to the nucleus (Homo sapiens)
REACT:R-HSA-5665748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds RHOC:GTP (Homo sapiens)
REACT:R-HSA-9707683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGRMC2 binds Hemes (Homo sapiens)
REACT:R-BTA-452122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Bos taurus)
RHEA:70504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopentenyl diphosphate => H(+) + isopentenyl phosphate + phosphate
REACT:R-DDI-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Dictyostelium discoideum)
REACT:R-CFA-9706336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SYK (Canis familiaris)
REACT:R-SSC-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)
GO:0102721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquinol:oxygen oxidoreductase activity
GO:0050387	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urethane amidohydrolase (decarboxylating)
GO:0050387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urethanase activity
GO:0050387	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urethane hydrolase activity
REACT:R-DME-4332359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active calmodulin binds CAMK2 (Drosophila melanogaster)
REACT:R-XTR-9009309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STUB1 (Xenopus tropicalis)
REACT:R-MMU-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Mus musculus)
RHEA:59426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H2O2 + NH4(+) => benzylamine + H2O + O2
REACT:R-HSA-5210892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cya and lef bind to pagA(197-794):ANTXR2 oligomer (Homo sapiens)
RHEA:33153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S(6)-acetyldihydrolipoamide + CoA => (R)-dihydrolipoamide + acetyl-CoA
RHEA:37270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-aspartate <=> L-alanine + L-aspartate
RHEA:18052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(2)-acetyl-L-ornithine <=> L-glutamate + N-acetyl-L-glutamate 5-semialdehyde
REACT:R-DRE-4719424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO1. (Danio rerio)
RHEA:56045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)
RHEA:52813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)
RHEA:28830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(out) + putrescine(in) <=> L-ornithine(in) + putrescine(out)
RHEA:28004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + dihydroxyacetone => beta-D-fructose 6-phosphate
REACT:R-RNO-2730841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV (Rattus norvegicus)
REACT:R-SSC-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Sus scrofa)
REACT:R-MMU-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Mus musculus)
REACT:R-RNO-9750555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Rattus norvegicus)
RHEA:52551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonate + NAD(+) <=> 2-dehydro-L-erythronate + H(+) + NADH
RHEA:60634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-oxoretinal + H(+) + NADH => all-trans-4-oxoretinol + NAD(+)
RHEA:61784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allulose = keto-L-fructose
RHEA:69058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+) => H(+) + N(omega)-methyl-L-arginine + NADH + O2
REACT:R-CFA-429567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Canis familiaris)
GO:0080007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-nitrosoglutathione reductase activity
RHEA:60413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monoglucosyl-enterobactin => [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)
REACT:R-DME-6804441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF34 or RFFL ubiquitinates phosphorylated TP53 (Drosophila melanogaster)
RHEA:33939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine + NADH + O2 = H2O + N(omega)-hydroxy-L-arginine + NAD(+)
RHEA:62935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-acetylcytidine <=> acetate + cytidine + H(+)
REACT:R-SPO-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Schizosaccharomyces pombe)
REACT:R-SSC-140355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS1 (Sus scrofa)
GO:0102989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-pentadecatrienylresorcinol synthase activity
REACT:R-CEL-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Caenorhabditis elegans)
RHEA:33550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lanosteryl hexadecanoate <=> H(+) + hexadecanoate + lanosterol
RHEA:41073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:18316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile <=> benzaldehyde + hydrogen cyanide
REACT:R-SSC-9724290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR2 binds GNRH1,2 (Sus scrofa)
GO:0043958	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	propionyl-CoA dehydrogenase
GO:0043958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADH
GO:0043958	skos:prefLabel	"acryloyl-CoA reductase (NADH)"
GO:0043958	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acryloyl-coenzyme A reductase activity
GO:0043958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acryloyl-CoA reductase (NADH) activity
GO:0043958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acryloyl-CoA reductase (NADH)"
GO:0043958	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acryloyl-CoA reductase activity
GO:0043958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylyl-CoA reductase (NADH)
REACT:R-HSA-3791319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NID1 degradation by MMP19 (Homo sapiens)
REACT:R-SPO-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Schizosaccharomyces pombe)
RHEA:31448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-2-oxohexanoate + H2O2 => 5-aminopentanoate + CO2 + H2O
REACT:R-GGA-936985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1 recruits TRAF6 (Gallus gallus)
REACT:R-HSA-110240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPG glycosylase mediated recognition and binding of hypoxanthine (Homo sapiens)
RHEA:57781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-4-nitrotoluene + NADH + O2 => 3-chloro-4-methylcatechol + NAD(+) + nitrite
REACT:R-BTA-3828025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP14 (Bos taurus)
REACT:R-XTR-9032073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-phosphorylated FRS2 binds GRB2 (Xenopus tropicalis)
REACT:R-DME-177107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion and activation of the latent large complex of TGF-beta-1 (Drosophila melanogaster)
RHEA:20120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-rhamnulose <=> ADP + H(+) + L-rhamnulose 1-phosphate
REACT:R-GGA-419011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectins (Gallus gallus)
REACT:R-BTA-1655851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2P hydrolyzes SREBP1A,1C,2 (Bos taurus)
REACT:R-PFA-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)
RHEA:22426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkyl thiol + NH4(+) + pyruvate => an S-alkyl-L-cysteine + H2O
REACT:R-RNO-198315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)
REACT:R-CFA-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Canis familiaris)
REACT:R-CFA-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Canis familiaris)
REACT:R-GGA-8948231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Gallus gallus)
REACT:R-SSC-1482776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Sus scrofa)
REACT:R-MMU-5668481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protesomal degradation of K48polyUb-TRAF3 (Mus musculus)
REACT:R-XTR-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Xenopus tropicalis)
RHEA:63778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-1183128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Rattus norvegicus)
GO:0016273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine N-methyltransferase activity
RHEA:18270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (S)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH
REACT:R-RNO-5693593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop extension by DNA polymerases (Rattus norvegicus)
REACT:R-DRE-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Danio rerio)
REACT:R-PFA-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Plasmodium falciparum)
REACT:R-RNO-5632738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDIT4 binds 14-3-3 dimer (Rattus norvegicus)
RHEA:33368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucose 6-phosphate(in) + L-histidyl-[protein]
RHEA:67413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Mus musculus)
REACT:R-BTA-8870678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fibrinogen products bind TLR4:LY96 (Bos taurus)
REACT:R-HSA-9697747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)
GO:0015213	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uracil/uridine permease activity
GO:0015213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine transmembrane transporter activity
RHEA:40844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + FADH2
GO:0032093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sterile Alpha Motif domain binding
GO:0032093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAM domain binding
REACT:R-DRE-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Danio rerio)
RHEA:64358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O => 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2
REACT:R-HSA-9633742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
GO:0008748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-ethylmaleimide reductase activity
GO:0008748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-ethylmaleimide + NADPH = N-ethylsuccinimide + NADP(+)
RHEA:46345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanoyl-CoA + tetradecanoyl-CoA => 3-oxo-2-methylhexadecanoyl-CoA + CoA
REACT:R-DRE-176494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to 27HCHOL (Danio rerio)
RHEA:57220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GTP
RHEA:49243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) <=> L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)
REACT:R-CFA-8875183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates activated MET (Canis familiaris)
REACT:R-GGA-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Gallus gallus)
REACT:R-RNO-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Rattus norvegicus)
REACT:R-CFA-6783524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM,LIF,CTF1 receptor complex binds gp130 (Canis familiaris)
REACT:R-BTA-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Bos taurus)
REACT:R-RNO-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)
REACT:R-RNO-5696131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC1 deaminates Hist (Rattus norvegicus)
RHEA:53895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-prenyl-L-cysteine + H2O + O2 <=> a prenal + H2O2 + L-cysteine
RHEA:38574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
REACT:R-GGA-573294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes free K63 linked pUb chains. (Gallus gallus)
REACT:R-SSC-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Sus scrofa)
REACT:R-BTA-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Bos taurus)
RHEA:34507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N,N'-diacetyllegionaminate synthase"
RHEA:34507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate = N,N-diacetyllegionaminate + phosphate
RHEA:34507	skos:prefLabel	"N,N'-diacetyllegionaminate synthase"
REACT:R-DME-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Drosophila melanogaster)
REACT:R-GGA-5602080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Gallus gallus)
REACT:R-DRE-8866542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Danio rerio)
RHEA:23959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
REACT:R-DRE-376357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp7 associated Lysosome to Plasma membrane transport (Danio rerio)
REACT:R-HSA-9021627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-DRE-6814096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds SCOC (Danio rerio)
RHEA:44761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
GO:0031773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled receptor 54 binding
GO:0031773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hOT7T175 receptor binding
GO:0031773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metastin receptor binding
GO:0031773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kisspeptin receptor binding
GO:0031773	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	kisspeptin receptor ligand
GO:0031773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KiSS-1 receptor binding
GO:0031773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypogonadotropin-1 receptor binding
REACT:R-BTA-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Bos taurus)
REACT:R-GGA-9756162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)
RHEA:16353	skos:altLabel	"taurine--glutamate transaminase"
RHEA:16353	skos:altLabel	"taurine--alpha-ketoglutarate aminotransferase"
RHEA:16353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taurine--2-oxoglutarate transaminase"
RHEA:16353	skos:altLabel	"taurine transaminase"
RHEA:16353	skos:prefLabel	"taurine--2-oxoglutarate transaminase"
RHEA:16353	skos:altLabel	"taurine aminotransferase"
RHEA:16353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + taurine = L-glutamate + sulfoacetaldehyde
REACT:R-XTR-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Xenopus tropicalis)
GO:0047614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aconitate delta2-delta3-isomerase activity
GO:0047614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aconitate delta-isomerase activity
GO:0047614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aconitate D-isomerase activity
GO:0047614	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aconitate isomerase activity
RHEA:19427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyimidazole-4-acetate + H2O + NAD(+) => H(+) + imidazole-4-acetate + NADH + O2
REACT:R-CFA-417842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 receptor can bind to LPA (Canis familiaris)
RHEA:67179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + primary fluorescent dioxobilin-type chlorophyll catabolite <=> H(+) + methanol + O13(4)-desmethyl pFDCC
REACT:R-HSA-9005988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the TRPC3 gene (Homo sapiens)
RHEA:41775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) <=> CMP + ganglioside GQ1b (d18:1(4E)) + H(+)
RHEA:12094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-acetoin => (S)-acetoin
RHEA:54725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
REACT:R-SSC-6809680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTM1 (Sus scrofa)
RHEA:18661	skos:prefLabel	"N(5)-(carboxyethyl)ornithine synthase"
RHEA:18661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) = H(+) + L-ornithine + NADPH + pyruvate
RHEA:18661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(5)-(carboxyethyl)ornithine synthase"
RHEA:44580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) = 2-all-trans-decaprenylphenol + CO2
REACT:R-HSA-9035983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HEXB does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)
REACT:R-GGA-375330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 45/Connexin 36 mediated neuronal gap junction communication (Gallus gallus)
RHEA:40407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SCE-203613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylation of eNOS (Saccharomyces cerevisiae)
GO:0070259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosyl-DNA phosphodiesterase activity
REACT:R-RNO-166726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MASPs (Rattus norvegicus)
REACT:R-SSC-265645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Influx through Voltage-gated Calcium Channels (Sus scrofa)
REACT:R-RNO-9027627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Rattus norvegicus)
RHEA:26455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADPH
REACT:R-HSA-5603379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT does not transfer CH3 from AdoMet to 6MP (Homo sapiens)
RHEA:10543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
REACT:R-RNO-176474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Rattus norvegicus)
REACT:R-XTR-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Xenopus tropicalis)
REACT:R-RNO-9021523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWP2 ubiquitinates NOTCH3 (Rattus norvegicus)
REACT:R-DRE-9640168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Danio rerio)
RHEA:28660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-lactose + H2O => beta-D-galactose + beta-D-glucose
REACT:R-MMU-4085029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU2 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)
RHEA:39884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-alpha-D-allose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH
REACT:R-PFA-9695890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Plasmodium falciparum)
RHEA:61730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-dehydro-D-glucoside => a 3-dehydro-D-guloside
REACT:R-MMU-9724670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds imiquimod (Mus musculus)
REACT:R-CFA-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Canis familiaris)
REACT:R-BTA-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Bos taurus)
REACT:R-XTR-376122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM/DSCAML1 homodimerization (Xenopus tropicalis)
REACT:R-BTA-114670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binds to vWF:Collagen complex (Bos taurus)
REACT:R-SSC-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Sus scrofa)
REACT:R-XTR-5358599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Xenopus tropicalis)
GO:0160008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein decrotonylase activity
GO:0160008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]
REACT:R-RNO-5205861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Rattus norvegicus)
REACT:R-XTR-139908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DLC2 by MAPK8 (Xenopus tropicalis)
RHEA:13059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylneuraminate + phosphate => an N-acylneuraminate 9-phosphate + H2O
GO:0102125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A9 16alpha,17 epoxidase activity
REACT:R-DRE-2467798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTTG1 (Securin) sequesters ESPL1 (Separase) (Danio rerio)
RHEA:72169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + taurohyodeoxycholate(in) => 2 Na(+)(out) + taurohyodeoxycholate(out)
RHEA:24111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methyl-2-oxoglutaramate <=> 2-oxoglutarate + methylamine
RHEA:33095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + inosine + phosphoenolpyruvate = futalosine
RHEA:19035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine => an N-acyl-D-glucosamine
RHEA:53864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) = 7,12-dioxo-lithocholate + H(+) + NADPH
REACT:R-CFA-3858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL recruits RAC (Canis familiaris)
REACT:R-BTA-77299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Bos taurus)
REACT:R-CFA-9614423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO1 (Canis familiaris)
RHEA:28805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate 6-phosphate => H2O + L-ascorbate 6-phosphate
RHEA:57470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-[(E)-feruloyl]-beta-D-glucose + UDP => (E)-ferulate + UDP-alpha-D-glucose
RHEA:71024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(in) + L-phenylalanine(out) => L-leucine(out) + L-phenylalanine(in)
REACT:R-MMU-420977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca permeable AMPA receptor ligand binding (Mus musculus)
RHEA:70121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:56093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-RNO-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Rattus norvegicus)
REACT:R-DME-8877813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND5A,B exchange GTP for GDP on RAB39 (Drosophila melanogaster)
RHEA:25628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + histamine + O2 <=> H2O2 + imidazole-4-acetaldehyde + NH4(+)
REACT:R-SSC-9009485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34:CSF1 binds CSF1R (Sus scrofa)
RHEA:24805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate + thiamine diphosphate = 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate
RHEA:53878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate => a cytidine in tRNA + acetyl-CoA + ATP + H2O
RHEA:44290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline
REACT:R-CFA-1236965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Export of peptide loaded MHC class I complex to PM (Canis familiaris)
REACT:R-SSC-5632652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds CDON and PTCH (Sus scrofa)
REACT:R-MMU-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Mus musculus)
REACT:R-XTR-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Xenopus tropicalis)
REACT:R-HSA-3296326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR1 binds LACT (Homo sapiens)
REACT:R-BTA-6785181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 bind LIPC dimer (Bos taurus)
REACT:R-MMU-420265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind IAPP(34-70) (Mus musculus)
RHEA:34171	skos:altLabel	"dihydrodipicolinate synthetase"
RHEA:34171	skos:prefLabel	"4-hydroxy-tetrahydrodipicolinate synthase"
RHEA:34171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-tetrahydrodipicolinate synthase"
RHEA:34171	skos:altLabel	"DHDPS"
RHEA:34171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O
EC:2.7.13.-	skos:prefLabel	"Protein-histidine kinases"
EC:2.7.13.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Protein-histidine kinases"
REACT:R-MMU-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)
REACT:R-HSA-8877941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SMAD1 in the nucleus (Homo sapiens)
REACT:R-CEL-2395879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)
REACT:R-RNO-8875531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS4 (Rattus norvegicus)
REACT:R-RNO-2162002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Rattus norvegicus)
RHEA:54007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
REACT:R-RNO-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Rattus norvegicus)
REACT:R-HSA-9698758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 ITD- and NOX4-dependent H2O2 production (Homo sapiens)
RHEA:48228	skos:prefLabel	"apolipoprotein N-acyltransferase"
RHEA:48228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"apolipoprotein N-acyltransferase"
RHEA:48228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]
RHEA:61884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate
RHEA:47325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-3-phenylpropanoate + pyruvate => 3-oxo-3-phenylpropanoate + L-alanine
REACT:R-CFA-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Canis familiaris)
REACT:R-CEL-5205649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 links damaged mitochondria to LC3 (Caenorhabditis elegans)
RHEA:31702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al
RHEA:33085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine => dehypoxanthine futalosine + S-adenosyl-L-methionine
REACT:R-BTA-5432825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds TLR4:LY96 (Bos taurus)
REACT:R-MMU-975629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11 reduces RBP2:atRAL to RBP2:atROL (Mus musculus)
REACT:R-MMU-159836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)
REACT:R-SSC-189398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)
RHEA:38880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(in) => a fatty acid(out)
REACT:R-HSA-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Homo sapiens)
REACT:R-DRE-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Danio rerio)
RHEA:55708	skos:prefLabel	"cysteine-dependent adenosine diphosphate thiazole synthase"
RHEA:55708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine-dependent adenosine diphosphate thiazole synthase"
RHEA:55708	skos:altLabel	"ADP-thiazole synthase"
RHEA:55708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide
GO:1902379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chemoattractant activity involved in axon chemotaxis
GO:1902379	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	chemoattractant activity involved in axon growth cone guidance
GO:1902379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemoattractant activity involved in axon pathfinding
GO:1902379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemoattractant activity involved in axon guidance
REACT:R-DRE-5654409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS2 (Danio rerio)
RHEA:42357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA
REACT:R-SSC-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Sus scrofa)
REACT:R-XTR-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Xenopus tropicalis)
RHEA:43022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + L-homocysteine => L,L-cystathionine
REACT:R-CFA-8982163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)
GO:0004133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen debranching enzyme activity
RHEA:28799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-prolinylglycine = glycine + L-proline
RHEA:32551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = (S)-alpha-terpineol + diphosphate
RHEA:32551	skos:prefLabel	"(-)-alpha-terpineol synthase"
RHEA:32551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-alpha-terpineol synthase"
RHEA:70396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + docosanoyl-CoA => CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine
REACT:R-CFA-2029458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)
REACT:R-DRE-6811479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 recruits EP300 to TP53 (Danio rerio)
RHEA:38730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol
RHEA:38444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + a long chain fatty alcohol => a wax ester + CoA
REACT:R-DDI-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Dictyostelium discoideum)
RHEA:59849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)
REACT:R-BTA-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Bos taurus)
REACT:R-DRE-8866268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADBRK1,2 phosphorylate AVPR2 (Danio rerio)
RHEA:61931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-miconazole(in) + ATP + H2O <=> (R)-miconazole(out) + ADP + H(+) + phosphate
REACT:R-CFA-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Canis familiaris)
REACT:R-CFA-9018858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Canis familiaris)
RHEA:11925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => globoside Gb3Cer (d18:1(4E)) + H(+) + UDP
REACT:R-DRE-9619756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2 binds ABCA1 (Danio rerio)
REACT:R-DDI-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Dictyostelium discoideum)
REACT:R-MMU-2160932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 binds phosphorylated PARD6A (Mus musculus)
REACT:R-BTA-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Bos taurus)
RHEA:28705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(out) => Cu(2+)(in)
RHEA:31196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH
RHEA:66024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O
REACT:R-RNO-9718020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PTGFR agonists (Rattus norvegicus)
REACT:R-MMU-9762343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDL:ALB dissociates (Mus musculus)
REACT:R-CFA-6811431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Canis familiaris)
REACT:R-XTR-3371385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α is cleaved by ADAM17 (TACE) (Xenopus tropicalis)
REACT:R-HSA-2022065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPGs are secreted (Homo sapiens)
REACT:R-XTR-5591040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves Factor Va intermediate form for Factor Va (Xenopus tropicalis)
REACT:R-CFA-5218809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Canis familiaris)
GO:0018127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)-serine ADP-ribosyltransferase activity
REACT:R-CFA-110354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of OGG1 glycosylase by APEX1 at the AP site (Canis familiaris)
RHEA:59536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoyl-CoA + hydrogencarbonate = (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate
REACT:R-BTA-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)
REACT:R-MMU-392530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S400-Cot phosphorylates NIK (Mus musculus)
REACT:R-HSA-8857928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIHBP1 binds HSPG:LPL dimer (Homo sapiens)
RHEA:57925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mutildienyl diphosphate => diphosphate + premutilin
RHEA:64114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + L-phenylalanine => an N-acyl-L-phenylalanine + H2O
REACT:R-CFA-4093331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras:GTP binds p120-RasGAP (Canis familiaris)
REACT:R-DME-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Drosophila melanogaster)
REACT:R-RNO-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Rattus norvegicus)
REACT:R-HSA-111289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)
REACT:R-RNO-3318486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Rattus norvegicus)
REACT:R-XTR-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Xenopus tropicalis)
REACT:R-SCE-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Saccharomyces cerevisiae)
RHEA:68169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5687183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKDC phosphorylates DCLRE1C at DNA DSBs (Danio rerio)
RHEA:16472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-benzylsuccinate + succinyl-CoA <=> (R)-2-benzylsuccinyl-CoA + succinate
GO:0047921	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentamicin acetyltransferase II activity
GO:0047921	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentamicin 2'-N-acetyltransferase activity
GO:0047921	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity
GO:0047921	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity
GO:0047921	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gentamycin acetyltransferase II
GO:0047921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside 2'-N-acetyltransferase activity
GO:0047921	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentamycin 2'-N-acetyltransferase activity
RHEA:72481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + trans-aconitate(out) => citrate(out) + trans-aconitate(in)
GO:0070513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	death domain binding
REACT:R-RNO-1358801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds RNF41 ubiquitin ligase (Rattus norvegicus)
RHEA:17789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase"
RHEA:17789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + H(+) + S-adenosyl-L-homocysteine
RHEA:17789	skos:prefLabel	"3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase"
EC:1.8.6.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With an nitrogenous group as acceptor"
EC:1.8.6.-	skos:prefLabel	"With an nitrogenous group as acceptor"
REACT:R-BTA-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Bos taurus)
REACT:R-HSA-9011313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades ubiquitinated ROBO3.1 (Homo sapiens)
REACT:R-CFA-2248891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARSA translocates to the lysosome (Canis familiaris)
REACT:R-GGA-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)
GO:0090523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome-b5 reductase activity, acting on NADPH
GO:0090523	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytochrome-b5 reductase activity
GO:0090523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + NADPH = 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)
REACT:R-DRE-216723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Danio rerio)
REACT:R-DRE-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)
REACT:R-BTA-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Bos taurus)
REACT:R-HSA-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)
RHEA:71644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide
RHEA:63446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H(+) + oxidized coenzyme F420-0 => (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin
RHEA:38248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + hexadecan-1-ol => 1-O-hexadecyl (9Z)-hexadecenoate + CoA
RHEA:61509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peonidin + UDP-alpha-D-glucose => peonidin 3-O-beta-D-glucoside + UDP
RHEA:66567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine + L-glutaminyl-[protein] <=> 5-histaminyl-L-glutamyl-[protein] + NH4(+)
EC:3.4.13.4	skos:prefLabel	"Xaa-Arg dipeptidase"
EC:3.4.13.4	skos:altLabel	"X-Arg dipeptidase"
EC:3.4.13.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Xaa-Arg dipeptidase"
EC:3.4.13.4	skos:altLabel	"aminoacyl-lysine dipeptidase"
EC:3.4.13.4	skos:altLabel	"N(2)-(4-amino-butyryl)-L-lysine hydrolase"
REACT:R-RNO-4420140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Rattus norvegicus)
REACT:R-RNO-8855747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Rattus norvegicus)
REACT:R-SCE-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)
REACT:R-GGA-110011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Grb10 to the insulin receptor (Gallus gallus)
REACT:R-HSA-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Homo sapiens)
RHEA:70223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate
REACT:R-BTA-8941628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
RHEA:53400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate
RHEA:35483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Xenopus tropicalis)
REACT:R-DRE-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Danio rerio)
REACT:R-SSC-3858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL recruits RAC (Sus scrofa)
RHEA:49200	skos:altLabel	"KDN 9-P synthase"
RHEA:49200	skos:prefLabel	"3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase"
RHEA:49200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase"
RHEA:49200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate
RHEA:49200	skos:altLabel	"2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase"
REACT:R-MMU-9707523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to BACH1:MAFK (Mus musculus)
REACT:R-XTR-192042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Xenopus tropicalis)
RHEA:60839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-adenosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate
RHEA:64743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate
RHEA:22093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:71159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-serine(out) + Na(+)(out) = H(+)(out) + L-serine(in) + Na(+)(in)
RHEA:56273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome cL] + H2O + methanol => 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)
REACT:R-HSA-4088210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic glycoconjugates translocate to the lysosome (Homo sapiens)
REACT:R-SSC-5693373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Sus scrofa)
REACT:R-SSC-2466085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from R* to release atRAL (Sus scrofa)
REACT:R-CFA-176521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Canis familiaris)
REACT:R-GGA-2197770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1 (FEEL-1) binds ligands (Gallus gallus)
RHEA:47075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoylglycerol + H2O <=> eicosanoate + glycerol + H(+)
RHEA:46988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2
REACT:R-DRE-6785126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA core complex assembles at DNA interstrand crosslinks (ICLs) (Danio rerio)
RHEA:43490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll b + H(+) + NADH => 7(1)-hydroxychlorophyll a + NAD(+)
REACT:R-CEL-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)
REACT:R-HSA-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Homo sapiens)
REACT:R-CEL-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)
RHEA:19837	skos:altLabel	"glucitol-6-phosphate dehydrogenase"
RHEA:19837	skos:altLabel	"ketosephosphate reductase"
RHEA:19837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol 6-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH
RHEA:19837	skos:prefLabel	"sorbitol-6-phosphate 2-dehydrogenase"
RHEA:19837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sorbitol-6-phosphate 2-dehydrogenase"
RHEA:51983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-N,N-dihydroxypolyhomomethionine + H(+) <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O
RHEA:52812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)
REACT:R-MMU-934604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SPRY2 is ubiquitinated by CBL (Mus musculus)
REACT:R-CEL-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
RHEA:22432	skos:altLabel	"beta-keto-reductase"
RHEA:22432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH
RHEA:22432	skos:prefLabel	"3-hydroxyacyl-CoA dehydrogenase"
RHEA:22432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxyacyl-CoA dehydrogenase"
RHEA:22432	skos:altLabel	"beta-hydroxyacyl dehydrogenase"
REACT:R-MMU-9709317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to free ferrohemoglobin (Mus musculus)
REACT:R-BTA-77593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage and polyadenylation of Intronless Pre-mRNA (Bos taurus)
REACT:R-SSC-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Sus scrofa)
REACT:R-DRE-5675948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFRSF6B binds TNFSF6,14,15 (Danio rerio)
REACT:R-SSC-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Sus scrofa)
RHEA:56975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (R)-methylmalonate semialdehyde + H(+) + NADH
REACT:R-SPO-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Schizosaccharomyces pombe)
RHEA:62906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose
REACT:R-DRE-2213244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides (Danio rerio)
RHEA:32965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + NH4(+) => 2-oxoglutaramate + H2O
RHEA:20136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(indol-3-yl)lactate + NAD(+) <=> H(+) + indole-3-pyruvate + NADH
REACT:R-DRE-9007539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates E2F6 (Danio rerio)
GO:0072320	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	swell-activated chloride channel
GO:0072320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	volume-sensitive chloride channel activity
RHEA:57046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate + H(+) + NADH => D-apionate + NAD(+)
RHEA:26558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O
REACT:R-HSA-5229111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 transports APP from trans-Golgi network to endosome lumen (Homo sapiens)
REACT:R-HSA-374922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenalin synaptic vesicle docking and priming (Homo sapiens)
REACT:R-SCE-5618331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC6 deacetylates microtubules (Saccharomyces cerevisiae)
REACT:R-SSC-8964619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds ARHGEF6 (Sus scrofa)
REACT:R-HSA-8856223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Homo sapiens)
REACT:R-RNO-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Rattus norvegicus)
REACT:R-SSC-1475025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Sus scrofa)
REACT:R-SSC-8854736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 binds FLT3 (Sus scrofa)
REACT:R-XTR-9604487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7:p-IRF7 translocates to the nucleus (Xenopus tropicalis)
REACT:R-HSA-2012084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive dimerization of FGFR3 cysteine mutants (Homo sapiens)
RHEA:53903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]
REACT:R-DRE-391372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRH1,2 (Danio rerio)
REACT:R-CEL-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Caenorhabditis elegans)
RHEA:26119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:26119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)"
RHEA:26119	skos:altLabel	"4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase"
RHEA:26119	skos:prefLabel	"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)"
RHEA:26119	skos:altLabel	"(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase"
RHEA:44061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA
REACT:R-SCE-8869606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NAR to yield NAMN (Saccharomyces cerevisiae)
RHEA:44519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)
REACT:R-CFA-1470012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus (Canis familiaris)
REACT:R-GGA-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Gallus gallus)
REACT:R-BTA-141367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylation of tBID by NMT1 (Bos taurus)
RHEA:51796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycohumulone + dimethylallyl diphosphate = colupulone + diphosphate + H(+)
RHEA:41944	skos:prefLabel	"[amino-group carrier protein]-L-2-aminoadipate 6-kinase"
RHEA:41944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP
RHEA:41944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[amino-group carrier protein]-L-2-aminoadipate 6-kinase"
RHEA:38791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-CFA-209772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to triiodothyronine (Canis familiaris)
RHEA:32267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + glyoxylate = glycine + succinate semialdehyde
RHEA:18950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol
EC:3.4.23.15	skos:altLabel	"angiotensinogenase"
EC:3.4.23.15	skos:altLabel	"angiotensin-forming enzyme"
EC:3.4.23.15	skos:prefLabel	"renin"
EC:3.4.23.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"renin"
REACT:R-DME-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Drosophila melanogaster)
RHEA:22502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloylacetyl-CoA + CO2 + CoA => (E)-feruloyl-CoA + H(+) + malonyl-CoA
REACT:R-GGA-9749197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 binds to H4K20me2 (Gallus gallus)
REACT:R-HSA-1592246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TFAM (Homo sapiens)
RHEA:49053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperlicin C + H(+) + NADH + O2 => asperlicin E + H2O + NAD(+)
REACT:R-GGA-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Gallus gallus)
RHEA:67809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine
REACT:R-HSA-9610327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3B (GRIN3B) (Homo sapiens)
RHEA:35192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	noranthrone + O2 => H2O + norsolorinic acid
REACT:R-DME-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Drosophila melanogaster)
RHEA:60739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesal + H2O + NADP(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADPH
REACT:R-SSC-6798489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A7 or S100A7A binds Zn2+ (Sus scrofa)
RHEA:61764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside E + UDP
REACT:R-XTR-1296037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with large conductance (Xenopus tropicalis)
REACT:R-BTA-1564164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type V degradation by MMP2,9,10 (Bos taurus)
REACT:R-CFA-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Canis familiaris)
RHEA:55390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-2,3-dihydrotabersonine + A
RHEA:31195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH
RHEA:34831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate = N-acyl-15-methylhexadecasphing-4-enine + phosphate
REACT:R-MMU-4719424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO1. (Mus musculus)
REACT:R-HSA-4793949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch) (Homo sapiens)
GO:0047198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-S-conjugate N-acetyltransferase activity
GO:0047198	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity
REACT:R-RNO-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Rattus norvegicus)
RHEA:14572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propane-1,2-diol <=> H2O + propanal
RHEA:68921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + pentanoate => AMP + diphosphate + NADP(+) + pentanal
RHEA:72444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-AMP + CoA => (E)-feruloyl-CoA + AMP + H(+)
REACT:R-MMU-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Mus musculus)
GO:0090590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity
REACT:R-HSA-6799981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 binds bacterial peptidoglycan (Homo sapiens)
RHEA:46100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = cortisol + H2O + 2 oxidized [adrenodoxin]
RHEA:47560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1b (d18:1(4E)) + H(+)
RHEA:23825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) => 2,3-dihydroxybenzoate + H(+) + NADH
REACT:R-XTR-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Xenopus tropicalis)
REACT:R-SSC-981728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to membrane-associated C3b (Sus scrofa)
GO:0030737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodophenol O-methyltransferase activity
GO:0030737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity
RHEA:39670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-CEL-9011595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Caenorhabditis elegans)
REACT:R-CEL-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Caenorhabditis elegans)
RHEA:45347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside NORint (d18:1(4E)) + H(+) + UDP
REACT:R-XTR-109343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Xenopus tropicalis)
REACT:R-SSC-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Sus scrofa)
RHEA:26103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-homoaconitate + H2O => (2R)-homocitrate
RHEA:70960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tyrosine + H2O + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)
REACT:R-MMU-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Mus musculus)
RHEA:30573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 AMP + 6 diphosphate + enterobactin + 4 H(+) => 3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine
RHEA:16787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine
RHEA:32372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin + 2 L-ascorbate => all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate
RHEA:56561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP
RHEA:72124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-butanoyl-(R)-carnitine(out) => Na(+)(in) + O-butanoyl-(R)-carnitine(in)
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HPPK
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydroxymethylpterin-pyrophosphokinase activity
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H2-pteridine-CH2OH pyrophosphokinase activity
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
GO:0003848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethyldihydropteridine pyrophosphokinase activity
GO:0008403	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP24
GO:0008403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxyvitamin D3 24-hydroxylase activity
GO:0008403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholecalciferol-24-hydroxylase activity
RHEA:54099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-CFA-209532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR C-terminal fragment enters endosomes (Canis familiaris)
REACT:R-XTR-159795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Xenopus tropicalis)
REACT:R-BTA-9013110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC binds effectors at the plasma membrane (Bos taurus)
REACT:R-HSA-211466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF1A-dependent synthesis of HNF4A (Homo sapiens)
RHEA:17126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine => 2-oxoglutarate + N-(2-aminobutanoyl)glycine
RHEA:23774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-p-cumate + H(+) + NADH => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)
RHEA:25474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + gamma-himachalene => (2E,6E)-farnesyl diphosphate
REACT:R-CFA-2485182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Canis familiaris)
REACT:R-RNO-9664881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)
REACT:R-RNO-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Rattus norvegicus)
REACT:R-MMU-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Mus musculus)
RHEA:44002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2
RHEA:36088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine
RHEA:20247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-O-adenylylstreptomycin + diphosphate => ATP + streptomycin
REACT:R-SSC-430021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAN2-PAN3 complex partially deadenylates mRNA (Sus scrofa)
GO:0015514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite extrusion permease activity
GO:0015514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite efflux transmembrane transporter activity
RHEA:33764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)
REACT:R-DME-432647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PER binds to TIM (Drosophila melanogaster)
REACT:R-RNO-352107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Rattus norvegicus)
REACT:R-CFA-622325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
RHEA:33282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
GO:0034528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-2-hydroxy-8-carboxychromene isomerase activity
RHEA:46444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(11Z)-hexadec-11-enoyl-CoA conjugase"
RHEA:46444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O
RHEA:46444	skos:prefLabel	"(11Z)-hexadec-11-enoyl-CoA conjugase"
REACT:R-DRE-174122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Danio rerio)
RHEA:63322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid(out) + ADP + H(+) + phosphate => a glycerophospholipid(in) + ATP + H2O
RHEA:70266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
REACT:R-GGA-5687097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3 binds ETV4 (Gallus gallus)
REACT:R-DRE-201630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Acinus (Danio rerio)
REACT:R-CEL-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Caenorhabditis elegans)
RHEA:19938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sarcosine
REACT:R-BTA-5649708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 recruits POLB to incised AP site (Bos taurus)
RHEA:29942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + phosphate(in) <=> H(+)(out) + phosphate(out)
REACT:R-GGA-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Gallus gallus)
RHEA:70425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + CoA + H(+) => an acyl-CoA + H2O
GO:0018581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)
GO:0018581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyquinol 1,2-dioxygenase activity
GO:0018581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyquinol dioxygenase activity
REACT:R-DME-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Drosophila melanogaster)
REACT:R-DRE-8953398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIR oxygenates quercetin (Danio rerio)
REACT:R-DDI-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Dictyostelium discoideum)
RHEA:49948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2
REACT:R-GGA-8867240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPCAM binds itself to form homotypic cell adhesion (Gallus gallus)
RHEA:42281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate
REACT:R-DDI-9025995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Dictyostelium discoideum)
REACT:R-HSA-381503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP6 binds IGF forming IGF:IGFBP6 (Homo sapiens)
REACT:R-SSC-2186767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SKI/SKIL (Sus scrofa)
GO:0004072	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:L-aspartate 4-phosphotransferase activity
GO:0004072	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-aspartokinase activity
GO:0004072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate kinase activity
GO:0004072	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic kinase activity
GO:0004072	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartokinase activity
REACT:R-MMU-6804253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates JMY (Mus musculus)
REACT:R-DME-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Drosophila melanogaster)
GO:0043539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein serine/threonine kinase activator activity
GO:0043539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein ser/thr kinase activator activity
REACT:R-SSC-432952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP180 interacts intracellularly with plectin and integrin beta4 (Sus scrofa)
REACT:R-HSA-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Homo sapiens)
REACT:R-SCE-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Saccharomyces cerevisiae)
RHEA:36502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-rhamnonate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH
REACT:R-CEL-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Caenorhabditis elegans)
RHEA:22004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain]
REACT:R-DRE-8952371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds RUNX3 (Danio rerio)
RHEA:58489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate + H(+) + NADH + O2 => H2O + NAD(+) + succinate semialdehyde + trimethylamine
REACT:R-HSA-5626228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The distal appendage proteins recruit TTBK2 (Homo sapiens)
RHEA:30481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-9661408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Sus scrofa)
RHEA:51687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl phosphate + CTP <=> (2E,6E)-farnesyl diphosphate + CDP
REACT:R-DME-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Drosophila melanogaster)
RHEA:37876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklanonate + S-adenosyl-L-methionine => methyl aklanonate + S-adenosyl-L-homocysteine
REACT:R-GGA-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Gallus gallus)
RHEA:19016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP + H2O <=> dTDP + H(+) + phosphate
RHEA:71426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)
REACT:R-XTR-5693564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with RAD52:DNA double-strand break ends (Xenopus tropicalis)
RHEA:51923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + AH2 <=> A + a quinol
RHEA:18160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyruvate <=> ADP + H(+) + phosphoenolpyruvate
RHEA:31363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)
RHEA:31363	skos:prefLabel	"8-hydroxy-5-deazaflavin:NADPH oxidoreductase"
RHEA:31363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-hydroxy-5-deazaflavin:NADPH oxidoreductase"
RHEA:13218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + succinate semialdehyde => 2 H(+) + NADH + succinate
REACT:R-HSA-751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gz complex dissociates (Homo sapiens)
RHEA:40100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:29354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zn(2+)(in) <=> Zn(2+)(out)
RHEA:34794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + O2 <=> formate + H(+) + hydroxymethylphosphonate
EC:3.4.21.103	skos:prefLabel	"physarolisin"
EC:3.4.21.103	skos:altLabel	"physaropepsin"
EC:3.4.21.103	skos:altLabel	"Physarum flavicomum aspartic proteinase"
EC:3.4.21.103	skos:altLabel	"Physarum aspartic proteinase"
EC:3.4.21.103	skos:altLabel	"Physarum polycephalum acid proteinase"
EC:3.4.21.103	skos:altLabel	"Dictyostelium discoideum aspartic proteinase"
EC:3.4.21.103	skos:altLabel	"Dictyostelium discoideum aspartic proteinase E"
EC:3.4.21.103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"physarolisin"
GO:0047038	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinitol 2-dehydrogenase (ribulose-forming) activity
GO:0047038	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming)
GO:0047038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol 2-dehydrogenase activity
REACT:R-CFA-6810724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3 binds the bacterial surface (Canis familiaris)
RHEA:25178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + CoA + NAD(+) => 3-methylbutanoyl-CoA + CO2 + NADH
REACT:R-HSA-4332235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds TGFBR2 (Homo sapiens)
REACT:R-DRE-174456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments of the C-strand (Danio rerio)
RHEA:46769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CEL-380901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked serotonin loaded synaptic vesicle (Caenorhabditis elegans)
REACT:R-DRE-114392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Danio rerio)
REACT:R-BTA-5635859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU dissociates (Bos taurus)
REACT:R-HSA-391933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP3 receptor can bind PGE2 (Homo sapiens)
REACT:R-CFA-198824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Canis familiaris)
REACT:R-SSC-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Sus scrofa)
REACT:R-MMU-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Mus musculus)
REACT:R-RNO-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)
REACT:R-HSA-9714477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the mitochondrial outer membrane (Homo sapiens)
REACT:R-BTA-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Bos taurus)
REACT:R-SSC-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Sus scrofa)
REACT:R-HSA-9694611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp4 is glycosylated (Homo sapiens)
REACT:R-DRE-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Danio rerio)
RHEA:42604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)
REACT:R-XTR-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)
REACT:R-SCE-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Saccharomyces cerevisiae)
EC:1.17.99.10	skos:prefLabel	"steroid C-25 hydroxylase"
EC:1.17.99.10	skos:altLabel	"cholesterol C-25 dehydrogenase"
EC:1.17.99.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steroid C-25 hydroxylase"
EC:1.17.99.10	skos:altLabel	"steroid C-25 dehydrogenase"
RHEA:56738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + retinoate => H2O + O2 + retinal
REACT:R-CEL-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Caenorhabditis elegans)
RHEA:55278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinyl tetradecanoate + CoA => 9-cis-retinol + tetradecanoyl-CoA
RHEA:19794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]
REACT:R-HSA-1482571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)
REACT:R-SCE-168440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Saccharomyces cerevisiae)
RHEA:33717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanal + phosphoethanolamine => 4-hydroxyeicosasphinganine 1-phosphate
RHEA:71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine
REACT:R-HSA-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Homo sapiens)
REACT:R-HSA-3149433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of VPU protein (Homo sapiens)
REACT:R-SSC-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Sus scrofa)
RHEA:20416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine <=> glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine
RHEA:57908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamyl-tRNA(Gln) = 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP
REACT:R-HSA-9027425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 (Homo sapiens)
REACT:R-CFA-1306965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Canis familiaris)
RHEA:69603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP = 3',5'-cyclic UMP + diphosphate
RHEA:59633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylobiose + O2 => D-xylobiono-1,5-lactone + H2O2
RHEA:15506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxymethylglutarate + NAD(+) => 2-formylglutarate + H(+) + NADH
REACT:R-BTA-432237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Bos taurus)
RHEA:36413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol => 7-dehydrocholesterol + hnu
REACT:R-XTR-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)
RHEA:20342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP
GO:0140685	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K9me demethylase activity
GO:0140685	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K9me2 demethylase activity
GO:0140685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD-dependent histone H3K9me/H3K9me2 demethylase activity
GO:0140685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-di/monomethyl-lysine-9 FAD-dependent demethylase activity
RHEA:12300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-uridine aminocarboxypropyltransferase"
RHEA:12300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine
RHEA:12300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) = 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine
RHEA:12300	skos:prefLabel	"tRNA-uridine aminocarboxypropyltransferase"
RHEA:18510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + NADH => 2 H2O + NAD(+)
RHEA:14589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin + S-adenosyl-L-methionine = chrysoeriol + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-193711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
REACT:R-CFA-429767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Canis familiaris)
GO:0018064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-L-histidine N-tele-methyltransferase activity
GO:0018064	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein methylase IV activity
GO:0018064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-histidine N-methyltransferase activity
GO:0018064	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein-histidine N-methyltransferase activity
GO:0018064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein (histidine) methyltransferase activity
GO:0018064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	actin-specific histidine methyltransferase activity
GO:0018064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl methionine:protein-histidine N-methyltransferase activity
GO:0018064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity
REACT:R-HSA-5624211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
GO:0033419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUA codon-amino acid adaptor activity
GO:0033419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine tRNA
GO:0033419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTA codon-amino acid adaptor activity
RHEA:55618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carotenoid epsilon-end group => a carotenoid psi-end group
REACT:R-DRE-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Danio rerio)
RHEA:38659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)
REACT:R-SPO-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Schizosaccharomyces pombe)
EC:3.2.1.212	skos:altLabel	"alpha-L-fucosidase"
EC:3.2.1.212	skos:prefLabel	"endo-(1->4)-fucoidanase"
EC:3.2.1.212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endo-(1->4)-fucoidanase"
EC:3.2.1.212	skos:altLabel	"poly(1,4-alpha-L-fucoside-2/3-sulfate) glycanohydrolase"
RHEA:63881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + thiocyanate => cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur
REACT:R-XTR-5212679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3A binds Me2sR4-HIST1H4 (Xenopus tropicalis)
REACT:R-DRE-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)
RHEA:71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+) => 2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH
RHEA:18640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + NADP(+) <=> H(+) + NADPH
REACT:R-DRE-8855825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTRA1 hydrolyzes ACAN (Aggrecan) (Danio rerio)
RHEA:56877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N-acetyl-1-phenylethylamine + H2O => (R)-1-phenylethylamine + acetate
REACT:R-DRE-5654569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS2 (Danio rerio)
GO:0005121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Toll ligand
GO:0005121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Toll binding
GO:0005121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Toll receptor binding
GO:0005121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tl binding
RHEA:24081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)
REACT:R-DRE-1236958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of particulate antigens with dendritic cell receptors (Danio rerio)
REACT:R-HSA-5661115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Homo sapiens)
GO:0047741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H(+)
GO:0047741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cetraxate-benzyl-ester benzylhydrolase activity
GO:0047741	skos:prefLabel	"cetraxate benzylesterase"
GO:0047741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cetraxate benzylesterase"
GO:0047741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cetraxate benzylesterase activity
REACT:R-BTA-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Bos taurus)
REACT:R-DME-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-HSA-5602672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective IRAK4 does not bind MyD88 within the TLR2/4 complex (Homo sapiens)
GO:0004395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
GO:0004395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHHB-Mt activity
GO:0004395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity
GO:0004395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyhexaprenylbenzoate methyltransferase activity
GO:0004395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexaprenyldihydroxybenzoate methyltransferase activity
GO:0004395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHHB methyltransferase activity
GO:0004395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity
REACT:R-HSA-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
GO:0140848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid:monoatomic cation antiporter activity
RHEA:19735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacteriochlorophyllide a + H(+) + NADH => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+)
GO:0034912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phthalate 3,4-cis-dihydrodiol dehydrogenase activity
REACT:R-XTR-209944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D binds GC (Xenopus tropicalis)
REACT:R-SSC-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Sus scrofa)
REACT:R-BTA-159179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Bos taurus)
RHEA:10898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + limonoate => 2 H2O + limonin
RHEA:58734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-CMP + diphosphate + H(+) => 5-methyl-CTP + H2O
RHEA:38479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine
REACT:R-MMU-9750016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Mus musculus)
REACT:R-HSA-168871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus (Homo sapiens)
REACT:R-HSA-5682629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Homo sapiens)
REACT:R-GGA-449087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD4 binds Interleukin-16 (Gallus gallus)
REACT:R-GGA-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Gallus gallus)
REACT:R-DRE-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Danio rerio)
REACT:R-CFA-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Canis familiaris)
RHEA:27808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + acetoacetyl-CoA => acetoacetate + acetyl-CoA
REACT:R-RNO-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Rattus norvegicus)
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvic carboxytransphosphorylase activity
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEP carboxyphosphotransferase activity
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEPCTrP
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvic carboxylase (pyrophosphate)
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphopyruvate carboxykinase
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate carboxyphosphotransferase activity
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate carboxylase (pyrophosphate)
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvic carboxykinase (pyrophosphate)
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate carboxykinase (pyrophosphate) activity
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate carboxykinase (diphosphate) activity
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate carboxylase (pyrophosphate)
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate carboxytransphosphorylase activity
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphoenolpyruvic carboxykinase
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate carboxykinase (pyrophosphate)
GO:0030585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)
RHEA:41958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine 2'-phosphate + H(+) => 2',3'-cyclophospho-CMP + H2O
RHEA:50113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + taurine => CoA + H(+) + N-octadecanoyl-taurine
RHEA:65002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + octanoyl-[ACP] => holo-[ACP] + octanoyl-AMP
REACT:R-HSA-9679780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIGMAR1 binds fluvoxamine (Homo sapiens)
GO:0018522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl-CoA reductase (dearomatizing) activity
GO:0018522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA reductase activity
GO:0018522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming) activity
REACT:R-CEL-397835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:Gq (active) dissociate (Caenorhabditis elegans)
RHEA:56517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + 2 H(+) + 2 H2O2 => 2 CO2 + 4 H2O + heme b
RHEA:68693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) => 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
RHEA:40633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate => H2O + trioctadecanoylglycerol
REACT:R-GGA-2404195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Gallus gallus)
RHEA:30739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate
GO:0004138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyguanosine kinase activity
GO:0004138	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxyguanosine kinase activity
GO:0004138	skos:prefLabel	"deoxyguanosine kinase"
GO:0004138	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyguanosine kinase (phosphorylating)
GO:0004138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyguanosine kinase"
GO:0004138	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NTP-deoxyguanosine 5'-phosphotransferase activity
GO:0004138	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:deoxyguanosine 5'-phosphotransferase activity
GO:0004138	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(dihydroxypropoxymethyl)guanine kinase activity
REACT:R-DDI-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)
RHEA:63197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10bR,4aS)-noroxomaritidine + H(+) + NADPH => (10bR,4aS)-oxomaritidine + NADP(+)
REACT:R-HSA-2066299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 binds phosphorylated WWTR1 (TAZ) (Homo sapiens)
RHEA:62001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + protoporphyrinogen IX => 3 AH2 + protoporphyrin IX
RHEA:23441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoate + H2O => 4-hydroxybenzoate + chloride + H(+)
RHEA:53230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-9707504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 oxidises ferrohemoglobin to MetHb (Sus scrofa)
REACT:R-DRE-8875568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 activates RAP1 (Danio rerio)
REACT:R-DME-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Drosophila melanogaster)
REACT:R-PFA-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Plasmodium falciparum)
REACT:R-DDI-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Dictyostelium discoideum)
RHEA:22729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + phosphate
RHEA:65407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + hexanoyl-CoA <=> butyl hexanoate + CoA
REACT:R-CFA-5654409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS2 (Canis familiaris)
REACT:R-CFA-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Canis familiaris)
RHEA:56527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydro-heme d1 <=> AH2 + heme d1
REACT:R-HSA-6814683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)
REACT:R-MMU-5682794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM22 and ADAM23 (Mus musculus)
REACT:R-SSC-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Sus scrofa)
RHEA:43676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-CFA-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Canis familiaris)
RHEA:42767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-HSA-205231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of KIT upon SCF binding (Homo sapiens)
REACT:R-GGA-163825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)
RHEA:15783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-3-(4-hydroxyphenyl)propanoate => L-tyrosine
RHEA:52496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-pent-2-en-1-ol + NADP(+) => (E)-2-pentenal + H(+) + NADPH
GO:0140808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]
GO:0140808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-protein-tyrosine ADP-ribosyltransferase activity
REACT:R-SCE-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Saccharomyces cerevisiae)
RHEA:65123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione <=> L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine
RHEA:36368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-alpha-hydroxyglutarate-gamma-lactone + H2O => 2-hydroxyglutarate + H(+)
REACT:R-CFA-3928598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of p190RhoGEF to p-FAK (Canis familiaris)
REACT:R-DME-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)
RHEA:47256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:45504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]
GO:0051921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcobyric acid synthase (glutamine-hydrolysing) activity
GO:0051921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ado-cobyric acid synthase [glutamine hydrolyzing] activity
GO:0051921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcobyric acid synthase (glutamine-hydrolyzing) activity
GO:0051921	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)
GO:0051921	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobyric acid synthase activity
GO:0051921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity
GO:0051921	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CobQ activity
REACT:R-HSA-5657641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALKBH2 binds alkylated DNA containing 1-meA (Homo sapiens)
REACT:R-XTR-909730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of INFAR1 by TYK2 (Xenopus tropicalis)
RHEA:20718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + S-inosyl-L-homocysteine => H(+) + H2O + S-adenosyl-L-homocysteine
REACT:R-XTR-5669012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA binds EDAR (Xenopus tropicalis)
REACT:R-SSC-110355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MUTYH glycosylase by APEX1 at the AP site (Sus scrofa)
GO:0047028	skos:altLabel	"pyruvoyl-tetrahydropterin reductase"
GO:0047028	skos:altLabel	"6-pyruvoyl-tetrahydropterin 2'-reductase"
GO:0047028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6PPH4(2'-oxo) reductase activity
GO:0047028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-pyruvoyltetrahydropterin 2'-reductase activity
GO:0047028	skos:altLabel	"6PPH4(2'-oxo) reductase"
GO:0047028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity
GO:0047028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-pyruvoyltetrahydropterin 2'-reductase"
GO:0047028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH
GO:0047028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-pyruvoyltetrahydropterin reductase activity
GO:0047028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity
GO:0047028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvoyl-tetrahydropterin reductase activity
GO:0047028	skos:altLabel	"6-pyruvoyl tetrahydropterin (2'-oxo)reductase"
GO:0047028	skos:prefLabel	"6-pyruvoyltetrahydropterin 2'-reductase"
GO:0047028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-pyruvoyl-tetrahydropterin 2'-reductase activity
RHEA:33464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	episterol + H(+) + NADPH + O2 => 5-dehydroepisterol + 2 H2O + NADP(+)
REACT:R-HSA-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Homo sapiens)
REACT:R-RNO-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Rattus norvegicus)
REACT:R-BTA-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Bos taurus)
RHEA:67724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP(out) + CMP-N-acetyl-beta-neuraminate(in) = CMP(in) + CMP-N-acetyl-beta-neuraminate(out)
RHEA:26224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:15679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + NH4(+) => 5-aminopentanamide + H2O
REACT:R-SSC-8938867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND3,(CCND1,CCND2) binds RUNX1 (Sus scrofa)
RHEA:56684	skos:prefLabel	"dihydrorhizobitoxine desaturase"
RHEA:56684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine
RHEA:56684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrorhizobitoxine desaturase"
REACT:R-BTA-996755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFPM proteins bind GATA proteins (Bos taurus)
RHEA:36752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-DRE-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Danio rerio)
RHEA:48989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + O2 + rifampicin => 2'-N-hydroxyrifampicin + H2O + NAD(+)
RHEA:43174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine => guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine
REACT:R-GGA-109813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1 binds SOS1 (Gallus gallus)
RHEA:43819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-DRE-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Danio rerio)
RHEA:30873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate + ADP + H(+) => 2-deoxy-D-ribose + ATP
REACT:R-RNO-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Rattus norvegicus)
REACT:R-CEL-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Caenorhabditis elegans)
REACT:R-RNO-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Rattus norvegicus)
REACT:R-HSA-377643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
REACT:R-MMU-8986994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Mus musculus)
RHEA:13445	skos:prefLabel	"pantetheine hydrolase"
RHEA:13445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pantetheine hydrolase"
RHEA:13445	skos:altLabel	"pantetheinase"
RHEA:13445	skos:altLabel	"vanin-1"
RHEA:13445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantetheine + H2O = (R)-pantothenate + cysteamine
REACT:R-BTA-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Bos taurus)
REACT:R-BTA-5357860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Bos taurus)
RHEA:17534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-glutamate
GO:0052732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3X11A
GO:0052732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoethanolamine phosphohydrolase activity
GO:0052732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoethanolamine phosphatase activity
GO:0052732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PHOSPHO1
REACT:R-HSA-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Homo sapiens)
REACT:R-MMU-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Mus musculus)
REACT:R-RNO-5653770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
REACT:R-GGA-177924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Gab1 by SHP2 (Gallus gallus)
RHEA:66678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate => (2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide
REACT:R-HSA-9709879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL scavenges O2.- (Homo sapiens)
RHEA:58256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] = ADP-D-ribose + L-seryl-[protein]
RHEA:46941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] => ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate
RHEA:56063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + hnu <=> CO2 + pentadecane
REACT:R-HSA-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)
REACT:R-SSC-4084994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU3 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)
RHEA:70859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(in) + L-glutamine(out) + Na(+)(out) = L-asparagine(out) + L-glutamine(in) + Na(+)(in)
RHEA:38070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
RHEA:29984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(in) + H(+)(in) => cytidine(out) + H(+)(out)
REACT:R-CFA-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Canis familiaris)
REACT:R-GGA-8851436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFHR dimers bind C3b (Gallus gallus)
RHEA:52805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-eremophilene + diphosphate
RHEA:15042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis-D-fructose 2',1:2,1'-dianhydride + H2O => inulobiose
RHEA:58353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate
REACT:R-SPO-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Schizosaccharomyces pombe)
RHEA:45286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-eicosanoyl-sphing-4-enine => eicosanoyl-CoA + sphing-4-enine
RHEA:46762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-5-nitrocatechol + NAD(+) + nitrite => 2,4-dinitrotoluene + NADH + O2
RHEA:42558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(2819) in 21S rRNA => uridine(2819) in 21S rRNA
REACT:R-SCE-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Saccharomyces cerevisiae)
GO:0052687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity
GO:0052687	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity
RHEA:38305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate 6-phosphate
EC:4.3.1.24	skos:prefLabel	"phenylalanine ammonia-lyase"
EC:4.3.1.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine ammonia-lyase"
REACT:R-SSC-4793911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates HSF1 (Sus scrofa)
RHEA:28827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(out) + putrescine(in) = L-ornithine(in) + putrescine(out)
REACT:R-SSC-8853755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Sus scrofa)
RHEA:43659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)
REACT:R-BTA-879222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP:NLRP1 binds ATP (Bos taurus)
RHEA:28524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate => D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O
REACT:R-BTA-8849102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRMS phosphorylates PTK6 (Bos taurus)
REACT:R-SCE-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Saccharomyces cerevisiae)
REACT:R-DME-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Drosophila melanogaster)
REACT:R-SPO-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Schizosaccharomyces pombe)
REACT:R-GGA-217204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation and association of ATM kinase at the DNA damage sites (Gallus gallus)
RHEA:38265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA
REACT:R-GGA-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Gallus gallus)
REACT:R-GGA-751019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:G12/13 complex dissociates (Gallus gallus)
RHEA:57321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] => CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]
REACT:R-BTA-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Bos taurus)
REACT:R-HSA-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)
REACT:R-CEL-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Caenorhabditis elegans)
REACT:R-PFA-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Plasmodium falciparum)
REACT:R-DRE-9707353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 binds Aromatase inhibitors (Danio rerio)
REACT:R-BTA-141348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAO:FAD oxidises NASPM to PTCN (Bos taurus)
GO:0048258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketoglucose-reductase activity
REACT:R-MMU-2465917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerisation of 11c-retinyl to at-retinyl (Mus musculus)
RHEA:55332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydroxyflavone + S-adenosyl-L-methionine = a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:16722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:19946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-SSC-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Sus scrofa)
REACT:R-MMU-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Mus musculus)
REACT:R-SSC-373714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-Heterodimerization of nephrin and KIRREL (Sus scrofa)
RHEA:31959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-CFA-8851538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside triphosphates (Canis familiaris)
REACT:R-RNO-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Rattus norvegicus)
REACT:R-DME-198440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Drosophila melanogaster)
REACT:R-DDI-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Dictyostelium discoideum)
RHEA:63920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine
REACT:R-BTA-8938231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds CREBBP (Bos taurus)
GO:0000277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity
GO:0000277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c-specific protein-lysine methyltransferase activity
GO:0000277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[cytochrome c]-lysine N-methyltransferase activity
GO:0000277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity
GO:0000277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c (lysine) methyltransferase activity
GO:0000277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c-lysine N-methyltransferase activity
GO:0000277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c methyltransferase activity
GO:0000277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c-specific protein methylase III activity
REACT:R-DME-210426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamate synaptic vesicle docking and priming (Drosophila melanogaster)
GO:0004557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-galactosidase A
GO:0004557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-galactoside galactohydrolase activity
GO:0004557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiase activity
GO:0004557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-galactoside galactohydrolase activity
GO:0004557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-galactosidase activity
GO:0004557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + melibiose = D-galactose + D-glucose
GO:0004557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-galactosidase activity
GO:0140605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton motive force-driven motor activity
REACT:R-CFA-5218824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds FYN (Canis familiaris)
REACT:R-MMU-2168079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL (GWL) phosphorylates ARPP19 (Mus musculus)
REACT:R-MMU-5654651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS3 (Mus musculus)
REACT:R-GGA-421485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of coproporphyrinogen III from the cytosol to the mitochondrial intermembrane space (Gallus gallus)
GO:0097109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuroligin family protein binding
RHEA:21777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate
REACT:R-HSA-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Homo sapiens)
REACT:R-RNO-9678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 binds S1PR1 agonists (Rattus norvegicus)
REACT:R-DDI-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Dictyostelium discoideum)
REACT:R-HSA-8963864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN dissociates from 25(OH)D (Homo sapiens)
REACT:R-XTR-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Xenopus tropicalis)
REACT:R-HSA-9603534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown caspase cleaves NTRK3 (Homo sapiens)
REACT:R-DRE-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Danio rerio)
GO:0019777	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	APG12 ligase activity
GO:0019777	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Atg12 ligase activity
GO:0019777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 transfers ATG12 from ATG7 to ATG10 (Homo sapiens)
GO:0019777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Atg12 transferase activity
GO:0019777	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Atg12 conjugating enzyme activity
GO:0019777	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	APG12 conjugating enzyme activity
REACT:R-HSA-9665409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR (Homo sapiens)
REACT:R-BTA-9707977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Bos taurus)
REACT:R-HSA-71590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)
RHEA:45201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)
RHEA:28968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline(in) + Na(+)(in) => L-proline(out) + Na(+)(out)
REACT:R-DRE-5682586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 and PIAS4 are recruited to DNA DSBs (Danio rerio)
RHEA:55718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O
GO:0036222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XTPase activity
GO:0036222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XTP pyrophosphohydrolase activity
GO:0036222	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hypoxanthine/xanthine dNTP pyrophosphatase
GO:0036222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XTP diphosphatase activity
GO:0036222	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	XTP/dITP diphosphatase
REACT:R-CFA-4641134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds AXIN (Canis familiaris)
REACT:R-HSA-8938965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and ELF1, ELF2 or PAX5 bind the BLK gene promoter (Homo sapiens)
RHEA:70440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 => a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate
RHEA:30347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + IDP = ADP + ITP
REACT:R-MMU-6801766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Mus musculus)
REACT:R-HSA-8853753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Homo sapiens)
REACT:R-RNO-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Rattus norvegicus)
REACT:R-CFA-9667965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds PP2A (Canis familiaris)
REACT:R-HSA-4167509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial BTD hydrolyses BCTN (Homo sapiens)
REACT:R-SSC-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Sus scrofa)
RHEA:48487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a propanoate ester + H2O <=> an aliphatic alcohol + H(+) + propanoate
REACT:R-HSA-74746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y427-SHC1 (Homo sapiens)
RHEA:28892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + putrescine(in) => H(+)(out) + putrescine(out)
REACT:R-HSA-6786789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer binds FLT3 (Homo sapiens)
REACT:R-CFA-9027321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)
REACT:R-MMU-5653756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM25 binds monoUb:164-PCNA (Mus musculus)
REACT:R-MMU-6804379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds TTC5 (Mus musculus)
REACT:R-MMU-8983300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Mus musculus)
REACT:R-XTR-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Xenopus tropicalis)
REACT:R-RNO-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Rattus norvegicus)
REACT:R-HSA-9696275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds GTP (Homo sapiens)
REACT:R-HSA-5668467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTNFR2 binds TNFA trimer:TNFR2 (Homo sapiens)
RHEA:58057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypotaurine + pyruvate => 2-sulfinoacetaldehyde + L-alanine
RHEA:65661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + calciol + H2O => AH2 + calcidiol
RHEA:57873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2,4-dihydroxycinnamoyl-CoA => CoA + umbelliferone
RHEA:58525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + H2O + NADPH => (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)
REACT:R-SSC-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Sus scrofa)
REACT:R-BTA-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Bos taurus)
REACT:R-SSC-9033520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves TYSND1 (Sus scrofa)
RHEA:55927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Rattus norvegicus)
RHEA:66290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base
REACT:R-DRE-9709317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to free ferrohemoglobin (Danio rerio)
RHEA:34095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyspermidine + H(+) = CO2 + spermidine
REACT:R-HSA-448660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL31:IL31RA:JAK1 binds OSMR:JAK1 (Homo sapiens)
RHEA:44816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-12 + CO2 + diphosphate
REACT:R-HSA-9694370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA9a is translated to Nucleoprotein (Homo sapiens)
REACT:R-MMU-2168923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XVIII endostatin release (Mus musculus)
RHEA:41829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexanoyl-[ACP] => (2E)-hexenoyl-[ACP] + H2O
REACT:R-MMU-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Mus musculus)
REACT:R-HSA-8983872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Homo sapiens)
REACT:R-HSA-6797269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSPA8, ALOX15 (Homo sapiens)
REACT:R-CEL-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Caenorhabditis elegans)
RHEA:22528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP
RHEA:22528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonol-3-O-glucoside L-rhamnosyltransferase"
RHEA:22528	skos:prefLabel	"flavonol-3-O-glucoside L-rhamnosyltransferase"
RHEA:22528	skos:altLabel	"uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase"
GO:0046404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent DNA 5'-hydroxyl-kinase activity
GO:0046404	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP-dependent polynucleotide 5'-hydroxyl-kinase activity
GO:0046404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0046404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent DNA kinase activity
GO:0046404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0046404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity
REACT:R-CFA-936941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Canis familiaris)
REACT:R-SSC-9013021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOB (Sus scrofa)
REACT:R-RNO-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Rattus norvegicus)
REACT:R-SSC-2161890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Sus scrofa)
REACT:R-RNO-193068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates PREG (Rattus norvegicus)
REACT:R-HSA-9021306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds and inactivates C1r, C1s (Homo sapiens)
RHEA:40385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP
RHEA:36692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-octadecanoylsphing-4-enine
REACT:R-MMU-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)
RHEA:50818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH
RHEA:44712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)
REACT:R-SSC-5654163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds PLCG1 (Sus scrofa)
REACT:R-CFA-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Canis familiaris)
RHEA:69693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP => ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine
RHEA:36881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2
RHEA:68966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxooctadecanoate + H2O2 => 2-hydroxyoctadecanoate + O2
RHEA:66708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate
REACT:R-CFA-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Canis familiaris)
RHEA:65897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-kynurenine => glycine + H2O + kynurenate
RHEA:51559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-glaucine + S-adenosyl-L-methionine <=> (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Drosophila melanogaster)
RHEA:37958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate
RHEA:53554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:35567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine = (9Z,12Z)-octadecadienoate + ethanolamine
REACT:R-CEL-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Caenorhabditis elegans)
REACT:R-HSA-4839638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
REACT:R-BTA-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)
REACT:R-DRE-4088218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetrastatin binds integrin alphaVbeta3 (Danio rerio)
RHEA:22067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-ergosta-7,22-diene-3beta,5-diol <=> ergosterol + H2O
RHEA:68097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA + H2O => a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)
REACT:R-RNO-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Rattus norvegicus)
RHEA:37784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:63782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine
REACT:R-BTA-8873850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD5 binds DCA, LCA (Bos taurus)
RHEA:27719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP => inosine + phosphate
GO:0070016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	armadillo repeat binding
GO:0070016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	armadillo domain binding
GO:0070016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arm repeat domain binding
GO:0070016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	armadillo repeat domain binding
REACT:R-HSA-421320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus (Homo sapiens)
REACT:R-RNO-2161794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is converted to HXA3/B3 by ALOX12 (Rattus norvegicus)
RHEA:34055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	festuclavine + NAD(+) = 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH
RHEA:34055	skos:altLabel	"festuclavine synthase"
RHEA:34055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"festuclavine dehydrogenase"
RHEA:34055	skos:prefLabel	"festuclavine dehydrogenase"
RHEA:48565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-ribosyl-trans-zeatin 5'-phosphate + H2O => D-ribose 5-phosphate + trans-zeatin
RHEA:58253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] => ADP-D-ribose + L-asparaginyl-[protein]
RHEA:55068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(35) in tRNA(Tyr) <=> pseudouridine(35) in tRNA(Tyr)
RHEA:49588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythrulose 1-phosphate = D-erythrulose 4-phosphate
RHEA:49588	skos:prefLabel	"L-erythrulose-1-phosphate isomerase"
RHEA:49588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-erythrulose-1-phosphate isomerase"
REACT:R-HSA-418581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated P2Y purinoceptor 1 binds G-protein Gq (Homo sapiens)
REACT:R-BTA-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Bos taurus)
REACT:R-SCE-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Saccharomyces cerevisiae)
RHEA:71633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(out) + sulfate(in) => phosphate(in) + sulfate(out)
REACT:R-DME-163751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Drosophila melanogaster)
RHEA:33783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1(F)-beta-D-fructosylsucrose + sucrose = 1,6-kestotetraose + beta-D-glucose
RHEA:57713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP
REACT:R-RNO-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Rattus norvegicus)
RHEA:48459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate
RHEA:47895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
RHEA:32929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O
REACT:R-SSC-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Sus scrofa)
REACT:R-CEL-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Caenorhabditis elegans)
RHEA:66455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH
REACT:R-DRE-1222491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoferrin scavenges iron ions (Danio rerio)
GO:0047386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-2,6-bisphosphate 6-phosphohydrolase activity
GO:0047386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity
GO:0047386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose-2,6-bisphosphate 6-phosphohydrolase activity
GO:0047386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose-2,6-bisphosphate 6-phosphatase activity
GO:0047386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 2,6-bisphosphate-6-phosphohydrolase activity
REACT:R-HSA-9625487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates downstream of EGFR (Homo sapiens)
REACT:R-HSA-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Homo sapiens)
REACT:R-HSA-8964567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CDK1 gene promoter (Homo sapiens)
RHEA:56616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene = 1,2,4-trichlorobenzene + chloride + H(+)
RHEA:25212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine <=> acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
RHEA:73002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] <=> L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]
REACT:R-GGA-437995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNK migrates to the nucleoplasm (Gallus gallus)
REACT:R-MMU-5686301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 binds SFTPAs (Mus musculus)
RHEA:23903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-stilbene oxide + H2O <=> (1R,2R)-hydrobenzoin
REACT:R-CFA-8987141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Canis familiaris)
RHEA:22251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) <=> 7,8-dihydroxykynurenate + H(+) + NADH
RHEA:17684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpropanoate + NAD(+) <=> 2-methyl-3-oxopropanoate + H(+) + NADH
RHEA:31208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + hexanoyl-CoA => (2E)-hexenoyl-CoA + FADH2
RHEA:57847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fraxetin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)
RHEA:16732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + H(+) + NADPH
GO:0102745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrogeranylgeranyl-PP reductase activity
REACT:R-RNO-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Rattus norvegicus)
REACT:R-CEL-429714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Caenorhabditis elegans)
REACT:R-HSA-9645394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Homo sapiens)
RHEA:20033	skos:prefLabel	"isopenicillin-N epimerase"
RHEA:20033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopenicillin N = penicillin N
RHEA:20033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopenicillin-N epimerase"
REACT:R-CEL-5252079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Caenorhabditis elegans)
REACT:R-GGA-9661625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FVIII is secreted (Gallus gallus)
REACT:R-RNO-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Rattus norvegicus)
RHEA:20234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7beta-hydroxysteroid + NADP(+) => a 7-oxosteroid + H(+) + NADPH
REACT:R-DME-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Drosophila melanogaster)
RHEA:40539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Sus scrofa)
REACT:R-SPO-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Schizosaccharomyces pombe)
RHEA:24240	skos:prefLabel	"adenylyl-sulfate reductase"
RHEA:24240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + AMP + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + AH2
RHEA:24240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylyl-sulfate reductase"
REACT:R-MMU-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Mus musculus)
REACT:R-RNO-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Rattus norvegicus)
REACT:R-DDI-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Dictyostelium discoideum)
GO:0047243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + UDP-alpha-D-glucose = (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP
GO:0047243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity
GO:0047243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavanone 7-O-beta-glucosyltransferase"
GO:0047243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hesperetin + UDP-alpha-D-glucose = (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP
GO:0047243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity
GO:0047243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavanone 7-O-beta-glucosyltransferase activity
GO:0047243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	naringenin 7-O-glucosyltransferase activity
GO:0047243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity
GO:0047243	skos:prefLabel	"flavanone 7-O-beta-glucosyltransferase"
GO:0047243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hesperetin 7-O-glucosyl-transferase activity
RHEA:23692	skos:prefLabel	"maleate hydratase"
RHEA:23692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maleate hydratase"
RHEA:23692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate = H2O + maleate
RHEA:45901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3Z)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA
REACT:R-MMU-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Mus musculus)
REACT:R-XTR-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Xenopus tropicalis)
RHEA:56897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + ATP + H(+) => an acyl-AMP + diphosphate
RHEA:26465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine <=> 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine
GO:0047166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkenylglycerophosphoethanolamine O-acyltransferase activity
GO:0047166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity
REACT:R-XTR-3927824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CASP8AP2 with SUMO1 (Xenopus tropicalis)
REACT:R-SPO-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Schizosaccharomyces pombe)
REACT:R-DRE-1433456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs (Danio rerio)
GO:0033461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGU codon-amino acid adaptor activity
GO:0033461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine tRNA
GO:0033461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT codon-amino acid adaptor activity
REACT:R-MMU-8938217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SWI/SNF complex (Mus musculus)
RHEA:27607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-SCE-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Saccharomyces cerevisiae)
RHEA:21315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxybenzoate + H(+) <=> CO2 + hydroquinone
REACT:R-BTA-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Bos taurus)
REACT:R-XTR-9733960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids dissociate from ALB (Xenopus tropicalis)
REACT:R-DRE-2396009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds c-di-GMP (Danio rerio)
REACT:R-MMU-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Mus musculus)
REACT:R-SCE-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Saccharomyces cerevisiae)
RHEA:17258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + vinorine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine
REACT:R-XTR-8858369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVRL1 binds BMP9,BMP10 (Xenopus tropicalis)
RHEA:63808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + spermidine = AMP + diphosphate + H(+) + N(8)-citryl-spermidine
REACT:R-XTR-2161745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)
RHEA:21029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]
GO:0050646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
GO:0050646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding
RHEA:66014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen]
RHEA:51003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine <=> [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-XTR-211924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4B1 12-hydroxylates ARA (Xenopus tropicalis)
REACT:R-BTA-9654523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP bind PDE6D on KRAS4B (Bos taurus)
RHEA:43135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine
REACT:R-BTA-5682010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10:ATG12 binds ATG5 (Bos taurus)
REACT:R-MMU-6784628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Mus musculus)
RHEA:35681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecasphinganine + CO2 + CoA => dodecanoyl-CoA + H(+) + L-serine
REACT:R-RNO-5654596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
REACT:R-CFA-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Canis familiaris)
RHEA:63257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)
RHEA:40535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Sus scrofa)
RHEA:54810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+) => H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2
RHEA:57824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP + H2O = 2-deoxy-D-ribose 5-phosphate + adenine
REACT:R-SSC-451283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kainate receptor binds glutamate (Sus scrofa)
REACT:R-XTR-197268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)
RHEA:71049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(out) + L-phenylalanine(in) => glycine(in) + L-phenylalanine(out)
RHEA:20566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => (1S,2S,4R)-endo-fenchol + diphosphate
REACT:R-DRE-5617037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Danio rerio)
REACT:R-DRE-1878002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLTs transfer Xyl to core protein (Danio rerio)
RHEA:14586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Canis familiaris)
REACT:R-XTR-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Xenopus tropicalis)
GO:0034416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-diphosphoglyceric acid phosphatase activity
GO:0034416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-diphosphoglycerate phosphatase activity
GO:0034416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphoglycerate phosphatase activity
GO:0034416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerate-2,3-diphosphate phosphatase activity
GO:0034416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisphosphoglycerate phosphatase activity
GO:0034416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bisphosphoglycerate phosphatase activity
REACT:R-CFA-1676204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Canis familiaris)
REACT:R-SPO-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Schizosaccharomyces pombe)
RHEA:51149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + 2 oxidized [azurin] => an aldehyde + 2 H(+) + 2 reduced [azurin]
REACT:R-HSA-3134953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 or DHX9 binds MyD88 (Homo sapiens)
REACT:R-SPO-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
RHEA:39475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA = (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O
REACT:R-CFA-400143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fatty acid ligands activate PPARA (Canis familiaris)
REACT:R-SCE-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Saccharomyces cerevisiae)
RHEA:12206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-3225851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin and activate MAP3K5 (Canis familiaris)
REACT:R-DRE-6806957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET receptor dimerizes (Danio rerio)
REACT:R-BTA-9020264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Bos taurus)
REACT:R-DDI-1614460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of procollagen type VI (Dictyostelium discoideum)
REACT:R-SSC-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Sus scrofa)
REACT:R-BTA-140783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Bos taurus)
RHEA:37970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NADP(+) <=> D-galactose + H(+) + NADPH
REACT:R-DRE-9749971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Danio rerio)
REACT:R-HSA-77340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Homo sapiens)
REACT:R-SSC-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Sus scrofa)
REACT:R-XTR-174441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Xenopus tropicalis)
REACT:R-RNO-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Rattus norvegicus)
GO:0033744	skos:altLabel	"methionine S-oxide reductase (S-form oxidizing)"
GO:0033744	skos:altLabel	"peptide Met(O) reductase"
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methyl sulfoxide reductase I and II activity
GO:0033744	skos:altLabel	"fSMsr"
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	free-methionine (S)-S-oxide reductase activity
GO:0033744	skos:altLabel	"methionine sulfoxide reductase"
GO:0033744	skos:altLabel	"acetylmethionine sulfoxide reductase"
GO:0033744	skos:altLabel	"methionine sulfoxide reductase A"
GO:0033744	skos:altLabel	"methyl sulfoxide reductase I and II"
GO:0033744	skos:altLabel	"methionine-S-oxide reductase"
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptide-methionine (S)-S-oxide reductase"
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-methionine-(S)-S-oxide reductase activity
GO:0033744	skos:prefLabel	"peptide-methionine (S)-S-oxide reductase"
GO:0033744	skos:altLabel	"free-methionine (S)-S-oxide reductase"
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine-S-oxide reductase activity
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine:oxidized-thioredoxin S-oxidoreductase activity
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fSMsr
GO:0033744	skos:altLabel	"methionine sulphoxide reductase A"
GO:0033744	skos:altLabel	"peptide methionine sulfoxide reductase"
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-methionine (S)-S-oxide reductase"
GO:0033744	skos:altLabel	"methionine S-oxide reductase"
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methionine sulfoxide reductase activity
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine:thioredoxin-disulfide S-oxidoreductase activity
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylmethionine sulfoxide reductase activity
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide
GO:0033744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]
GO:0033744	skos:prefLabel	"L-methionine (S)-S-oxide reductase"
RHEA:64754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanyl-1-pentanol + NH4(+) + pyruvate => 3-sulfanylpentan-1-ol-L-cysteine + H2O
GO:0031685	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	adenosine receptor ligand
GO:0031685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine receptor binding
RHEA:38251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + octadecanoyl-CoA = CoA + hexadecanyl octadecanoate
GO:0102671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-6a-hydroxymaackiain 3-O-methyltransferase"
GO:0102671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine = (+)-pisatin + H(+) + S-adenosyl-L-homocysteine
GO:0102671	skos:altLabel	"HM3OMT"
GO:0102671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6a-hydroxymaackiain-3-O-methyltransferase activity
GO:0102671	skos:prefLabel	"(+)-6a-hydroxymaackiain 3-O-methyltransferase"
GO:0031531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyrotropin releasing hormone receptor binding
GO:0031531	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thyrotropin-releasing hormone receptor ligand
GO:0031531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyrotropin-releasing hormone receptor binding
REACT:R-RNO-8868659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
REACT:R-DRE-446364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Migfilin interacts with VASP (Danio rerio)
RHEA:33468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydroepisterol + H(+) + NADPH + O2 => ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)
RHEA:17370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhizin + H2O => 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate
REACT:R-XTR-9668419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Xenopus tropicalis)
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACS
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl CoA synthase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acyl-activating enzyme activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short chain fatty acyl-CoA synthetase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-activating enzyme activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short-chain acyl-coenzyme A synthetase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate-CoA ligase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl activating enzyme
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetic thiokinase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA synthetase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetate to acetyl-CoA
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl CoA ligase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA synthase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetate thiokinase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-coenzyme A synthase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A synthetase activity
GO:0003987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetate:CoA ligase (AMP-forming)
RHEA:37620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-BTA-2581474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK1,4,7 phosphorylate MII to p-MII (Bos taurus)
REACT:R-DME-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Drosophila melanogaster)
REACT:R-SSC-5676589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANKL,sRANKL trimer binds RANK (Sus scrofa)
GO:0034594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol trisphosphate phosphatase activity
REACT:R-CFA-8933446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Canis familiaris)
REACT:R-HSA-8851877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Homo sapiens)
RHEA:40279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + dodecanoyl-CoA = CoA + O-dodecanoyl-R-carnitine
RHEA:32564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => alpha-terpinene + diphosphate
GO:0106019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-4,5-bisphosphate phosphatase activity
GO:0043857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylornithine transcarbamylase activity
GO:0043857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity
GO:0043857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity
GO:0043857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylornithine transcarbamylase activity
GO:0043857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AOTC
GO:0043857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylornithine carbamoyltransferase activity
EC:1.1.2.10	skos:prefLabel	"lanthanide-dependent methanol dehydrogenase"
EC:1.1.2.10	skos:altLabel	"Ce(3+)-induced methanol dehydrogenase"
EC:1.1.2.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lanthanide-dependent methanol dehydrogenase"
EC:1.1.2.10	skos:altLabel	"La(3+)-dependent MDH"
EC:1.1.2.10	skos:altLabel	"cerium dependent MDH"
RHEA:19816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-asparagine <=> 2-oxosuccinamate + an L-alpha-amino acid
RHEA:47257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine <=> aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine
RHEA:19823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+)
RHEA:46210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + eicosanoyl-CoA => ATP + CoA + eicosanoate
GO:0080095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylethanolamine-sterol O-acyltransferase activity
REACT:R-HSA-3240957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PRC2-EZH2 complex (Homo sapiens)
REACT:R-HSA-8983077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds TSLP:IL7R:CRLF2 (Homo sapiens)
REACT:R-CFA-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Canis familiaris)
GO:0050201	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:beta-L-fucose 1-phosphotransferase activity
GO:0050201	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fucose kinase activity
GO:0050201	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fucose kinase activity
GO:0050201	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:6-deoxy-L-galactose 1-phosphotransferase activity
GO:0050201	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fucokinase activity
GO:0050201	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fucokinase (phosphorylating) activity
GO:0050201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucokinase activity
REACT:R-CFA-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Canis familiaris)
REACT:R-SSC-4722133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Sus scrofa)
RHEA:25547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate <=> diphosphate + ent-pimara-9(11),15-diene
REACT:R-HSA-8878050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 and EP300 (Homo sapiens)
RHEA:37192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-AMP + H2O => adenosine 2'-phosphate + H(+)
REACT:R-DME-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Drosophila melanogaster)
RHEA:16291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH => (1R,2S)-ephedrine + NAD(+)
REACT:R-BTA-2408524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Bos taurus)
RHEA:51347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
REACT:R-CFA-8854736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 binds FLT3 (Canis familiaris)
REACT:R-RNO-5578777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMPK phosphorylates PLN (Rattus norvegicus)
REACT:R-SSC-9020278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Sus scrofa)
RHEA:61502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-beta-D-glucoside + UDP => delphinidin + UDP-alpha-D-glucose
RHEA:20285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,3-beta-galactosyl-N-acetylhexosamine phosphorylase"
RHEA:20285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine
RHEA:20285	skos:altLabel	"lacto-N-biose phosphorylase"
RHEA:20285	skos:prefLabel	"1,3-beta-galactosyl-N-acetylhexosamine phosphorylase"
RHEA:20285	skos:altLabel	"LNBP"
RHEA:20285	skos:altLabel	"galacto-N-biose phosphorylase"
REACT:R-BTA-2294600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates condensin II subunit NCAPD3 (Bos taurus)
REACT:R-XTR-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Xenopus tropicalis)
REACT:R-RNO-5626981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Rattus norvegicus)
GO:0019535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric-vibriobactin transmembrane transporter activity
REACT:R-SCE-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Saccharomyces cerevisiae)
RHEA:66226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-DeltaC9-CoA + H2O2 => asc-C9-CoA + O2
GO:0003727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded RNA binding
GO:0003727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ssRNA binding
REACT:R-HSA-2161563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGJ2 is isomerised to delta12-PGJ2 (Homo sapiens)
REACT:R-CFA-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Canis familiaris)
RHEA:30996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B
REACT:R-HSA-193097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregnenolone translocates from the mitochondrial matrix to the cytosol (Homo sapiens)
REACT:R-DDI-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Dictyostelium discoideum)
RHEA:12685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 mycothiol + NADP(+) = H(+) + mycothione + NADPH
REACT:R-DME-5654637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
RHEA:57048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]
REACT:R-DME-5626962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB2L1 binds IKKA:IKKB:NEMO (Drosophila melanogaster)
RHEA:49277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + phytyl phosphate => CDP + phytyl diphosphate
EC:3.1.6.20	skos:prefLabel	"S-sulfosulfanyl-L-cysteine sulfohydrolase"
EC:3.1.6.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-sulfosulfanyl-L-cysteine sulfohydrolase"
REACT:R-MMU-5685953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates RBBP8 (Mus musculus)
REACT:R-DRE-2130504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of lip22 to lip10 (Danio rerio)
REACT:R-SCE-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-CEL-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Caenorhabditis elegans)
RHEA:42858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O
REACT:R-RNO-3095889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC dealkylates RCbl (Rattus norvegicus)
RHEA:60580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0061928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione specific gamma-glutamylcyclotransferase activity
REACT:R-XTR-77594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Xenopus tropicalis)
REACT:R-DRE-191654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-src associates with Cx43 in gap junctions (Danio rerio)
REACT:R-DDI-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Dictyostelium discoideum)
RHEA:19345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate
RHEA:19345	skos:altLabel	"dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase"
RHEA:19345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trihydroxypterocarpan dimethylallyltransferase"
RHEA:19345	skos:altLabel	"glyceollin synthase"
RHEA:19345	skos:prefLabel	"trihydroxypterocarpan dimethylallyltransferase"
RHEA:19345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate
RHEA:19345	skos:altLabel	"dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase"
RHEA:19345	skos:altLabel	"dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase"
REACT:R-BTA-9753285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)
REACT:R-HSA-164832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase synthesizes ATP (Homo sapiens)
REACT:R-HSA-3465459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)
REACT:R-SSC-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Sus scrofa)
REACT:R-MMU-9625482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated EGFR (Mus musculus)
REACT:R-PFA-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Plasmodium falciparum)
RHEA:50471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH <=> 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)
RHEA:24218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesoate + 2 H(+) + NADH => (2E,6E)-farnesal + H2O + NAD(+)
REACT:R-CEL-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Caenorhabditis elegans)
REACT:R-RNO-9603991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Rattus norvegicus)
REACT:R-HSA-2201341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TRAM (TICAM2) (Homo sapiens)
REACT:R-DRE-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Danio rerio)
RHEA:34754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acyl-15-methylhexadecasphing-4-enine <=> ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate
RHEA:39607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH = (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)
GO:0004049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilate synthetase activity
GO:0004049	skos:prefLabel	"anthranilate synthase"
GO:0004049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthranilate synthase"
GO:0004049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate synthase activity
GO:0004049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chorismate pyruvate-lyase (amino-accepting) activity
GO:0004049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate
REACT:R-RNO-5656064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FLRT1,2,3 (Rattus norvegicus)
REACT:R-SSC-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Sus scrofa)
REACT:R-XTR-5669097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA trimer binds TNFRSF1A,1B,14 (Xenopus tropicalis)
REACT:R-SSC-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Sus scrofa)
RHEA:32301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 diphosphate + NAD(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADH
REACT:R-DRE-109759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Danio rerio)
RHEA:34832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => N-acyl-15-methylhexadecasphing-4-enine + phosphate
GO:0000249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-22 sterol desaturase activity
RHEA:38341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + D-glucose => (20S)-ginsenoside Rb1 + H2O
RHEA:25610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-allofuranose => beta-D-allopyranose
GO:0140902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine:sodium symporter activity
GO:0140902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:glutamine symporter activity
GO:0140902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:L-glutamine symporter activity
GO:0140902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine:sodium symporter activity
REACT:R-CFA-187020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of pro-beta-NGF is processed to mature beta-NGF (Canis familiaris)
RHEA:44137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl dodecanoate
REACT:R-BTA-9610152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Bos taurus)
REACT:R-HSA-159771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein C to protein C (Homo sapiens)
RHEA:10945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + psi-UMP => phosphate + pseudouridine
RHEA:31813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + viridiflorene => (2E,6E)-farnesyl diphosphate
REACT:R-HSA-211301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDX1-dependent synthesis of IAPP protein (Homo sapiens)
RHEA:55798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hydroquinone + NAD(+) => H(+) + NADH + O2 + phenol
REACT:R-RNO-159431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Rattus norvegicus)
RHEA:55988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
RHEA:55988	skos:altLabel	"processing A-glucosidase I"
RHEA:55988	skos:prefLabel	"mannosyl-oligosaccharide glucosidase"
RHEA:55988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosyl-oligosaccharide glucosidase"
RHEA:55988	skos:altLabel	"Glc3Man9NAc2 oligosaccharide glucosidase"
RHEA:32742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Xenopus tropicalis)
REACT:R-SCE-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Saccharomyces cerevisiae)
RHEA:67206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + tryptamine => H2O + N-acetyltryptamine
RHEA:13820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + H2O + phylloquinone <=> 2,3-epoxyphylloquinone + [protein]-dithiol
REACT:R-DME-8858500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC10A binds Tn-MUC1 (Drosophila melanogaster)
REACT:R-DDI-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Dictyostelium discoideum)
REACT:R-GGA-1675473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B binds JAK2 (Gallus gallus)
RHEA:48359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
RHEA:19494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose + phosphate => alpha-D-glucose 1-phosphate + D-glucose
REACT:R-SSC-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Sus scrofa)
RHEA:64095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)
REACT:R-MMU-5340195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4 binds DCA, CDCA, LCHA (Mus musculus)
GO:0050649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone 6-beta-hydroxylase activity
GO:0050649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone 6b-hydroxylase activity
REACT:R-GGA-6805573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I/type II heterodimers form tetramers (Gallus gallus)
RHEA:37005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA => (11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA
RHEA:16413	skos:prefLabel	"lipoyl amidotransferase"
RHEA:16413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]
RHEA:16413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipoyl amidotransferase"
RHEA:11162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate 4-semialdehyde + L-glutamate => 2-oxoglutarate + L-2,4-diaminobutanoate
GO:0042263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPF receptor activity
GO:0042263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuropeptide F receptor activity
REACT:R-RNO-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Rattus norvegicus)
REACT:R-HSA-374669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds NRP1 (Homo sapiens)
REACT:R-MMU-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Mus musculus)
REACT:R-RNO-8875071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSS3 ligates CoA to CH3COO- (Rattus norvegicus)
REACT:R-HSA-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
GO:0097508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthine DNA N-glycosylase activity
GO:0097508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthine-DNA glycosylase activity
RHEA:22917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-hydroxyacetophenone + H(+) + NADPH + O2 => 4-acetoxyphenol + H2O + NADP(+)
RHEA:53944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) = (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH
REACT:R-DME-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Drosophila melanogaster)
REACT:R-SPO-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Schizosaccharomyces pombe)
REACT:R-BTA-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Bos taurus)
GO:0032557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine ribonucleotide binding
REACT:R-RNO-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)
GO:0050133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-hydroxylysine O-acetyltransferase activity
GO:0050133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity
GO:0050133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-hydroxylysine acetylase activity
GO:0050133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(6)-hydroxylysine acetylase activity
GO:0050133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity
GO:0050133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-hydroxylysine:acetyl CoA N6-transacetylase activity
REACT:R-DDI-211929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C19 5-hydroxylates omeprazole (Dictyostelium discoideum)
RHEA:19280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)
REACT:R-DRE-2186771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 binds SMAD7 (Danio rerio)
RHEA:31450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-2-oxohexanoate + H2O2 <=> 5-aminopentanoate + CO2 + H2O
REACT:R-SCE-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Saccharomyces cerevisiae)
RHEA:44667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)
RHEA:10808	skos:prefLabel	"(S)-2-hydroxypropylphosphonic acid epoxidase"
RHEA:10808	skos:altLabel	"(S)-2-hydroxypropylphosphonate epoxidase"
RHEA:10808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-2-hydroxypropylphosphonic acid epoxidase"
RHEA:10808	skos:altLabel	"2-hydroxypropylphosphonic acid epoxidase"
RHEA:10808	skos:altLabel	"HPP epoxidase"
RHEA:10808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-epoxypropylphosphonate + 2 H2O
REACT:R-CFA-202510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1-TAB2 complex (Canis familiaris)
REACT:R-XTR-9709842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS binds TOMM70 (Xenopus tropicalis)
REACT:R-RNO-5689649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 (Rattus norvegicus)
RHEA:63384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine
RHEA:29383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + H2O = 2'-deoxyinosine + phosphate
REACT:R-DME-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Drosophila melanogaster)
REACT:R-RNO-450984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Rattus norvegicus)
RHEA:15324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triglucosyl-enterobactin <=> [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)
RHEA:65090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane E + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:30737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + phosphate => 1D-myo-inositol 4-phosphate + H2O
REACT:R-HSA-379387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DA to form 3MT (Homo sapiens)
RHEA:10576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + N-methylethanolamine phosphate = CDP-N-methylethanolamine + diphosphate
RHEA:10576	skos:prefLabel	"N-methylphosphoethanolamine cytidylyltransferase"
RHEA:10576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-methylphosphoethanolamine cytidylyltransferase"
REACT:R-DDI-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Dictyostelium discoideum)
RHEA:22130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-camphor + H(+) + NADH => (1S,2R,4S)-borneol + NAD(+)
RHEA:20274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
RHEA:71687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-aspartate(out) + 2 H(+)(out) = glycyl-L-aspartate(in) + 2 H(+)(in)
REACT:R-RNO-8873923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 binds LPCAT1 and PC (Rattus norvegicus)
REACT:R-GGA-373024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ (Gallus gallus)
RHEA:60048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)
RHEA:43870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out) => a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in)
REACT:R-CFA-2396561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)
RHEA:39432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-DME-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Drosophila melanogaster)
REACT:R-SSC-5674366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RD binds p-2S MAP2Ks and MAPKs (Sus scrofa)
GO:0050401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylonate dehydratase activity
GO:0050401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O
GO:0050401	skos:altLabel	"D-xylo-aldonate dehydratase"
GO:0050401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylonate hydro-lyase activity
GO:0050401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylonate dehydratase"
GO:0050401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)
GO:0050401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylonate dehydratase activity
GO:0050401	skos:prefLabel	"xylonate dehydratase"
GO:0050401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylo-aldonate dehydratase activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD transporter activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized nicotinamide adenine dinucleotide transmembrane transporter activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH transporter activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced NAD transporter activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide adenine dinucleotide transmembrane transporter activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD (reduced) transporter activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD transmembrane transporter activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced nicotinamide adenine dinucleotide transmembrane transporter activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized NAD transporter activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ transporter activity
GO:0051724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD (oxidized) transporter activity
RHEA:60930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:33648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + ATP + CoA => (9Z)-hexadecenoyl-CoA + AMP + diphosphate
RHEA:36040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH
REACT:R-HSA-1433418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Homo sapiens)
REACT:R-HSA-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Homo sapiens)
RHEA:24982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate => 3-hydroxy-4-methylanthranilate + ATP + H(+)
GO:0062241	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA repair factory
GO:0062241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double strand break-nuclear membrane anchor activity
REACT:R-BTA-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Bos taurus)
RHEA:49394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-CFA-141200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates of PEA (Canis familiaris)
RHEA:53449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate
RHEA:49934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5Z)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA
REACT:R-DRE-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Danio rerio)
RHEA:67847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:14786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA(n) + UTP => diphosphate + RNA(n)-3'-uridine ribonucleotide
REACT:R-DRE-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)
REACT:R-HSA-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Homo sapiens)
RHEA:72654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 <=> 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)
RHEA:36574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-(tetradecanoyl)-sphinganine
RHEA:41310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-CFA-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Canis familiaris)
REACT:R-RNO-5654399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS2 (Rattus norvegicus)
REACT:R-SSC-109380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Sus scrofa)
REACT:R-RNO-5682893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12:ATG7:CysO572-ATG7 binds ATG10 (Rattus norvegicus)
RHEA:53318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate
REACT:R-BTA-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Bos taurus)
REACT:R-SSC-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Sus scrofa)
REACT:R-GGA-450333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)
REACT:R-CEL-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Caenorhabditis elegans)
REACT:R-MMU-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Mus musculus)
REACT:R-CFA-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Canis familiaris)
RHEA:42591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
RHEA:20180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine + UDP-alpha-D-glucose <=> 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP
RHEA:41474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CEL-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)
RHEA:32883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinic aldehyde + NADP(+) = (+)-artemisinic aldehyde + H(+) + NADPH
RHEA:32883	skos:prefLabel	"artemisinic aldehyde Delta(11(13)) reductase"
RHEA:32883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"artemisinic aldehyde Delta(11(13)) reductase"
REACT:R-SSC-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Sus scrofa)
RHEA:63307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate
GO:0050092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	meso-tartrate dehydrogenase activity
GO:0050092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-tartrate:NAD+ oxidoreductase activity
REACT:R-RNO-964800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuromedin-U receptors bind neuromedins U, S (Rattus norvegicus)
REACT:R-DRE-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Danio rerio)
REACT:R-DME-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Drosophila melanogaster)
REACT:R-HSA-844617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IPAF binds procaspase-1 (Homo sapiens)
RHEA:41182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)
RHEA:48555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> (10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)
REACT:R-MMU-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Mus musculus)
REACT:R-SSC-1855179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Sus scrofa)
REACT:R-MMU-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Mus musculus)
RHEA:61170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose
RHEA:34595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isopentadecanoyl-CoA + L-serine = 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA
REACT:R-HSA-6803230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of moderate activity BRAF complexes (Homo sapiens)
REACT:R-DRE-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Danio rerio)
REACT:R-DME-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Drosophila melanogaster)
RHEA:67552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + cholate = adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)
RHEA:31953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
GO:0050131	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methylamino acid oxidase activity
GO:0050131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-L-amino-acid oxidase activity
GO:0050131	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)
REACT:R-SSC-8938853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 binds RUNX1 (Sus scrofa)
RHEA:58768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)
RHEA:22281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-demethylpuromycin + S-adenosyl-L-methionine => H(+) + puromycin + S-adenosyl-L-homocysteine
REACT:R-XTR-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Xenopus tropicalis)
RHEA:15847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose
RHEA:32187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-5-en-3-one = cholest-4-en-3-one
GO:0018553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity
REACT:R-HSA-445757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1 receptor antagonist protein binds Interleukin 1 receptors (Homo sapiens)
REACT:R-SSC-199050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Sus scrofa)
REACT:R-DRE-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Danio rerio)
REACT:R-HSA-975188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
RHEA:54524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + H(+) + methylglyoxal = 3-hydroxyhexane-2,5-dione + CO2
REACT:R-BTA-9708457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HM13 cleaves HMOX1 dimer (Bos taurus)
REACT:R-DRE-8932275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Danio rerio)
REACT:R-BTA-8983845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dissociates from IL6ST:IL6ST (Bos taurus)
RHEA:33929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde => 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2
GO:0034949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1-dichloroethane reductive dehalogenase activity
REACT:R-HSA-373061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)
GO:0038199	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethylene response sensor
GO:0038199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylene receptor activity
GO:0038199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2H4 receptor activity
REACT:R-RNO-76354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vinyl chloride is oxidized to 2-Chloroethylene oxide (Rattus norvegicus)
REACT:R-SPO-2990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO1 to UBA2:SAE1 (Schizosaccharomyces pombe)
RHEA:11701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + progesterone => H2O + NADP(+) + testosterone acetate
REACT:R-SSC-2002401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Sus scrofa)
RHEA:64948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + H2O = dCDP + H(+) + phosphate
REACT:R-HSA-4608855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRICKLE1 is degraded by the proteasome (Homo sapiens)
RHEA:68032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cystathionine ketimine + 2 H(+) + NADH = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)
RHEA:56854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + toxoflavin => reumycin + S-adenosyl-L-methionine
REACT:R-HSA-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Homo sapiens)
REACT:R-CEL-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-GGA-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Gallus gallus)
RHEA:10623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamaldehyde + CoA + NADP(+) <=> (E)-cinnamoyl-CoA + H(+) + NADPH
REACT:R-SSC-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Sus scrofa)
REACT:R-MTU-868657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose (Mycobacterium tuberculosis)
RHEA:67714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+) => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O
REACT:R-RNO-437118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI stimulates PI3K beta, gamma (Rattus norvegicus)
GO:0047502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sabinol dehydrogenase activity
GO:0047502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-cis-sabinol:NAD+ oxidoreductase activity
GO:0047502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-cis-sabinol dehydrogenase activity
REACT:R-HSA-9754191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene (Homo sapiens)
REACT:R-MMU-5671970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CIT binds KIF14 and PRC1 (Mus musculus)
RHEA:45319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin D2 <=> 11beta-prostaglandin F2 + NADP(+)
REACT:R-DRE-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Danio rerio)
REACT:R-SSC-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Sus scrofa)
RHEA:49842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (-)-dehydrodiconiferyl acid + 2 a quinone + H2O
RHEA:34502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate
REACT:R-HSA-159803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Homo sapiens)
RHEA:32452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate => all-trans-phytoene + 2 diphosphate
REACT:R-XTR-1474210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP14 (Xenopus tropicalis)
REACT:R-BTA-936960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
REACT:R-HSA-8961907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the CDC45 gene promoter (Homo sapiens)
REACT:R-DRE-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-SSC-2213017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF3 (Sus scrofa)
REACT:R-SSC-9007539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates E2F6 (Sus scrofa)
RHEA:59119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + O2 <=> [protein]-disulfide + H2O2
GO:0099107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion channel regulator activity involved in G-protein coupled receptor signaling pathway
GO:0099107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion channel regulator activity involved in G protein-coupled receptor signaling pathway
REACT:R-HSA-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Homo sapiens)
REACT:R-HSA-202453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Homo sapiens)
REACT:R-CFA-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Canis familiaris)
RHEA:15366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP
REACT:R-SSC-2022860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Sus scrofa)
REACT:R-DRE-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Danio rerio)
RHEA:20448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arogenate + oxaloacetate <=> L-aspartate + prephenate
EC:3.4.24.48	skos:altLabel	"hemorrhagic metalloproteinase HT-2"
EC:3.4.24.48	skos:prefLabel	"ruberlysin"
EC:3.4.24.48	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ruberlysin"
EC:3.4.24.48	skos:altLabel	"Crotalus ruber metalloendopeptidase II"
EC:3.4.24.48	skos:altLabel	"hemorrhagic toxin II"
REACT:R-HSA-9703435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 fusions activate STAT5 (Homo sapiens)
REACT:R-GGA-2993780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO1 from E1 to UBE2I (UBC9) (Gallus gallus)
REACT:R-XTR-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Xenopus tropicalis)
REACT:R-GGA-75244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL binds FAS Receptor (Gallus gallus)
GO:0030627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-mRNA 5' splice site binding
GO:0030627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-mRNA 5'-splice site binding
RHEA:13773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-stylopine synthase"
RHEA:13773	skos:altLabel	"(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming)"
RHEA:13773	skos:prefLabel	"(S)-stylopine synthase"
RHEA:13773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sedoheptulokinase (phosphorylating)
GO:0050277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulokinase activity
GO:0050277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:sedoheptulose 7-phosphotransferase activity
GO:0050277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heptulokinase activity
REACT:R-SSC-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Sus scrofa)
RHEA:70775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-D-quinovose + FMNH2 + O2 = 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite
REACT:R-HSA-9759157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent SQSTM1 gene expression (Homo sapiens)
REACT:R-DRE-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Danio rerio)
RHEA:17084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-isoeugenol <=> H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol
GO:0047904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose dehydrogenase activity
GO:0047904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose:(acceptor) 5-oxidoreductase activity
GO:0047904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 5-dehydrogenase (acceptor)
GO:0047904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 5-dehydrogenase activity
GO:0047904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose:acceptor 5-oxidoreductase activity
RHEA:41006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine
REACT:R-DRE-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Danio rerio)
RHEA:39317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA
REACT:R-RNO-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Rattus norvegicus)
RHEA:21314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + hydroquinone => 2,5-dihydroxybenzoate + H(+)
REACT:R-CEL-5622134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRABP1 binds atRA (Caenorhabditis elegans)
REACT:R-SSC-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Sus scrofa)
REACT:R-RNO-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Rattus norvegicus)
REACT:R-CEL-2672334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNN channels transport extracellular Na+ to cytosol (Caenorhabditis elegans)
RHEA:55218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + rhizathalene A => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-CEL-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Caenorhabditis elegans)
REACT:R-BTA-2046089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Bos taurus)
RHEA:34214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecgonine methyl ester + NADP(+) <=> ecgonone methyl ester + H(+) + NADPH
RHEA:64786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + ethanethiol => S-ethyl-L-cysteine
REACT:R-DME-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)
REACT:R-DRE-204863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang2 (Danio rerio)
RHEA:54361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + H(+) => 3-methylbutanal + CO2
GO:0050558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose epimerase activity
GO:0050558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltose 1-epimerase activity
RHEA:15268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate
RHEA:10560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O = 2,5-dioxopentanoate + NH4(+)
RHEA:10560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-pyrroline-4-hydroxy-2-carboxylate deaminase"
RHEA:10560	skos:prefLabel	"1-pyrroline-4-hydroxy-2-carboxylate deaminase"
REACT:R-DRE-6800200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-HGF to form HGF dimer (Danio rerio)
REACT:R-RNO-71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Rattus norvegicus)
REACT:R-MMU-1632843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1 binds DYNLL1,DYNLL2 (Mus musculus)
REACT:R-MMU-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Mus musculus)
EC:1.1.1.344	skos:prefLabel	"dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)(+)]"
EC:1.1.1.344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)(+)]"
REACT:R-DRE-8944250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXV (Danio rerio)
RHEA:60519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan <=> D-tryptophan
REACT:R-CFA-975593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Canis familiaris)
RHEA:32003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene
REACT:R-RNO-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Rattus norvegicus)
REACT:R-XTR-9018880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Xenopus tropicalis)
RHEA:35148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)
RHEA:10127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + phenylacetone <=> benzyl acetate + H2O + NADP(+)
RHEA:11524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH
REACT:R-HSA-2065539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:Importin beta-1 dissociates (Homo sapiens)
REACT:R-CFA-708349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD2 oligomerizes (Canis familiaris)
REACT:R-RNO-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Rattus norvegicus)
REACT:R-RNO-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Rattus norvegicus)
RHEA:49123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + protoviolaceinate <=> H2O + NADP(+) + violaceinate
REACT:R-HSA-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)
RHEA:41424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 = formate + grixazone A + H(+) + 3 H2O
REACT:R-CFA-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Canis familiaris)
REACT:R-CFA-8854209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A binds JFC1 (Canis familiaris)
RHEA:42233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:69178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanoate + L-lysyl-[protein] => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]
RHEA:30467	skos:prefLabel	"(+)-endo-beta-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]"
RHEA:30467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphate
RHEA:30467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-endo-beta-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]"
REACT:R-SPO-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Schizosaccharomyces pombe)
REACT:R-CEL-109539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Caenorhabditis elegans)
REACT:R-SCE-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Saccharomyces cerevisiae)
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short-chain acyl-coenzyme A dehydrogenase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethylene reductase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short-chain acyl CoA dehydrogenase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	unsaturated acyl coenzyme A reductase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short-chain-acyl-CoA dehydrogenase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyryl-CoA dehydrogenase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyacyl CoA reductase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyryl dehydrogenase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	unsaturated acyl-CoA reductase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyryl coenzyme A dehydrogenase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butanoyl-CoA:acceptor 2,3-oxidoreductase activity
GO:0004085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl-coenzyme A reductase activity
REACT:R-HSA-6810030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR2 binds MTMR10 (Homo sapiens)
REACT:R-HSA-9609899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane (Homo sapiens)
GO:0034513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	box H/ACA snoRNA binding
REACT:R-MMU-4608852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 ubiquitinates PRICKLE1 (Mus musculus)
RHEA:61389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin(in) + H2O => ADP + biotin(out) + H(+) + phosphate
RHEA:62818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dinapinone E + 2 H2O => 4 monapinone E + O2
REACT:R-DME-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Drosophila melanogaster)
REACT:R-XTR-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Xenopus tropicalis)
RHEA:32824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) => phosphate(out)
REACT:R-BTA-8983835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Bos taurus)
REACT:R-BTA-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Bos taurus)
RHEA:52719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)
REACT:R-HSA-5660757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-SNCA dissociates from the conjugating enzyme (Homo sapiens)
REACT:R-XTR-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Xenopus tropicalis)
REACT:R-CFA-6794347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 dimerizes (Canis familiaris)
RHEA:65312	skos:prefLabel	"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I"
RHEA:65312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I"
RHEA:65312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]
RHEA:65312	skos:altLabel	"beta-ketoacyl-acyl carrier protein synthase KasA"
EC:1.1.99.-	skos:prefLabel	"With other acceptors"
EC:1.1.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
GO:0050029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine alpha-oxidase activity
GO:0050029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine oxidase activity
GO:0050029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysyl-alpha-oxidase activity
GO:0050029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine:oxygen 2-oxidoreductase (deaminating)
REACT:R-SSC-6791218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)
GO:0090541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIT domain binding
REACT:R-GGA-6784006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Gallus gallus)
RHEA:32977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O
REACT:R-CFA-202375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ITK to SLP-76 (Canis familiaris)
RHEA:27651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + uridine => GDP + H(+) + UMP
RHEA:12770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-gluconate => 2-dehydro-D-gluconate + AH2
RHEA:34435	skos:prefLabel	"4-dimethylallyltryptophan N-methyltransferase"
RHEA:34435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-dimethylallyltryptophan N-methyltransferase"
RHEA:34435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine
RHEA:55429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:30245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 4 monodehydro-L-ascorbate radical => 4 L-ascorbate + O2
RHEA:18902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-benzyloxycarbonyl-L-leucine => benzyl alcohol + CO2 + L-leucine
REACT:R-GGA-8956099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Gallus gallus)
GO:0102405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-taxifolin 5'-hydroxylase activity
REACT:R-BTA-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Bos taurus)
REACT:R-BTA-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Bos taurus)
REACT:R-HSA-6793096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370 (Homo sapiens)
REACT:R-HSA-376122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM/DSCAML1 homodimerization (Homo sapiens)
RHEA:22241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylenediurea => N-(carboxyaminomethyl)urea + NH4(+)
REACT:R-RNO-174448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex on the C-strand of the telomere (Rattus norvegicus)
REACT:R-BTA-9014293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GDIs block activation of RAC2 (Bos taurus)
RHEA:25618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terpentedienyl diphosphate => diphosphate + terpentetriene
REACT:R-HSA-141040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)
REACT:R-HSA-8866269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB bind GPCRs (Homo sapiens)
REACT:R-CEL-4793911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates HSF1 (Caenorhabditis elegans)
REACT:R-MMU-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Mus musculus)
RHEA:64928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dADP + H2O = dAMP + H(+) + phosphate
REACT:R-XTR-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Xenopus tropicalis)
RHEA:42553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(31) in tRNA => pseudouridine(31) in tRNA
REACT:R-HSA-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Homo sapiens)
REACT:R-SCE-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-MMU-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Mus musculus)
REACT:R-SPO-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Schizosaccharomyces pombe)
REACT:R-HSA-9660536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)
RHEA:16269	skos:altLabel	"NC-reductase"
RHEA:16269	skos:altLabel	"methyl red azoreductase"
RHEA:16269	skos:altLabel	"p-aminoazobenzene reductase"
RHEA:16269	skos:altLabel	"dimethylaminobenzene reductase"
RHEA:16269	skos:altLabel	"dibromopropylaminophenylazobenzoic azoreductase"
RHEA:16269	skos:altLabel	"NADPH:4-(dimethylamino)azobenzene oxidoreductase"
RHEA:16269	skos:altLabel	"orange I azoreductase"
RHEA:16269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) = 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH
RHEA:16269	skos:altLabel	"azoreductase"
RHEA:16269	skos:altLabel	"NADPH-dependent azoreductase"
RHEA:16269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"azobenzene reductase"
RHEA:16269	skos:altLabel	"orange II azoreductase"
RHEA:16269	skos:altLabel	"nicotinamide adenine dinucleotide (phosphate) azoreductase"
RHEA:16269	skos:altLabel	"p-dimethylaminoazobenzene azoreductase"
RHEA:16269	skos:altLabel	"NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase"
RHEA:16269	skos:prefLabel	"azobenzene reductase"
RHEA:16269	skos:altLabel	"N,N-dimethyl-4-phenylazoaniline azoreductase"
RHEA:16269	skos:altLabel	"new coccine (NC)-reductase"
RHEA:16269	skos:altLabel	"azo reductase"
RHEA:16269	skos:altLabel	"azo-dye reductase"
RHEA:58470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2
REACT:R-RNO-69600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic degradation of ubiquitinated-Cdc25A (Rattus norvegicus)
GO:0030976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin pyrophosphate binding
GO:0030976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aneurine pyrophosphate binding
GO:0030976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPP binding
GO:0030976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cocarboxylase binding
GO:0030976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine pyrophosphate binding
GO:0030976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphothiamin binding
RHEA:65269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypentacecilide A + H(+) + NADPH + O2 => chrodrimanin F + H2O + NADP(+)
REACT:R-HSA-9007467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PRC1L4 complex binds the CDC7 gene promoter (Homo sapiens)
REACT:R-GGA-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Gallus gallus)
REACT:R-XTR-427514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC deacetylates histone H3 (Xenopus tropicalis)
REACT:R-HSA-8950362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBI3:CANX binds IL12A (Homo sapiens)
REACT:R-SSC-202168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ZAP-70 by Lck (Sus scrofa)
REACT:R-RNO-8862152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Rattus norvegicus)
RHEA:18195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]
REACT:R-GGA-139920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tBID to mitochondria (Gallus gallus)
REACT:R-HSA-400509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Homo sapiens)
RHEA:50804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin J2 = prostaglandin J2-S-(R)-glutathione
RHEA:35889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA
REACT:R-DRE-5250217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP binds ARL2BP (Danio rerio)
REACT:R-DME-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Drosophila melanogaster)
REACT:R-HSA-109342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation (Homo sapiens)
REACT:R-SSC-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Sus scrofa)
REACT:R-DDI-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Dictyostelium discoideum)
RHEA:67511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:61983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + ubiquinone-10 <=> NADP(+) + ubiquinol-10
REACT:R-CFA-2065549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Canis familiaris)
REACT:R-RNO-176700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Rattus norvegicus)
REACT:R-BTA-195408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Bos taurus)
REACT:R-CEL-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Caenorhabditis elegans)
REACT:R-RNO-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Rattus norvegicus)
RHEA:23645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-451470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 (Gallus gallus)
RHEA:72421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-AMP + diphosphate => (E)-4-coumarate + ATP + H(+)
RHEA:28621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutyronitrile + H(+) + NADPH + O2 <=> 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)
RHEA:51641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate
GO:0001665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
GO:0001665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity
GO:0001665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GalNAc alpha-2,6-sialyltransferase I activity
RHEA:64221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine
REACT:R-DDI-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)
REACT:R-XTR-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Xenopus tropicalis)
RHEA:20457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH
RHEA:55055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pentanoyl-CoA <=> CoA + H(+) + pentanoate
RHEA:33945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADH + 4 O2
REACT:R-GGA-8982641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Gallus gallus)
REACT:R-HSA-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Homo sapiens)
REACT:R-MMU-1606807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Mus musculus)
REACT:R-SSC-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Sus scrofa)
RHEA:22650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[cytochrome c] + heme b => holo-[cytochrome c]
RHEA:26005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol 1-phosphate + NAD(+) <=> D-xylulose 5-phosphate + H(+) + NADH
REACT:R-DRE-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Danio rerio)
REACT:R-DRE-9648983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Danio rerio)
REACT:R-HSA-374248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)
REACT:R-HSA-8953556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
REACT:R-DRE-193763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Danio rerio)
REACT:R-RNO-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Rattus norvegicus)
REACT:R-BTA-190260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b binds to FGF (Bos taurus)
RHEA:48098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine
RHEA:12516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate
RHEA:12516	skos:altLabel	"(+)-(10R)-germacrene A synthase"
RHEA:12516	skos:altLabel	"GAS"
RHEA:12516	skos:altLabel	"(+)-germacrene A synthase"
RHEA:12516	skos:altLabel	"germacrene A synthase"
RHEA:12516	skos:prefLabel	"germacrene-A synthase"
RHEA:12516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"germacrene-A synthase"
RHEA:16273	skos:prefLabel	"ceramide cholinephosphotransferase"
RHEA:16273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ceramide cholinephosphotransferase"
RHEA:16273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + CDP-choline = a sphingomyelin + CMP + H(+)
REACT:R-SSC-201712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin:TCF associates with BCL9 and PYGO (Sus scrofa)
GO:0004873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asialoglycoprotein receptor activity
REACT:R-DRE-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Danio rerio)
REACT:R-CFA-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Canis familiaris)
RHEA:47478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA => (3E)-tetradecenoyl-CoA
REACT:R-HSA-2162229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol (Homo sapiens)
REACT:R-DRE-8939335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 polyubiquinates BCL10 (Danio rerio)
GO:0034186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein A-I binding
REACT:R-DME-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)
REACT:R-MMU-166817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by C3 convertases (Mus musculus)
RHEA:40186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O2
REACT:R-RNO-1678841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Rattus norvegicus)
REACT:R-SSC-6805479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53RK phosphorylates TP53 (Sus scrofa)
REACT:R-SCE-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Saccharomyces cerevisiae)
REACT:R-HSA-6803545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to phagosomal lumen (Homo sapiens)
REACT:R-SCE-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)
RHEA:31297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopent-4-enoate => (2E)-2-hydroxypenta-2,4-dienoate
REACT:R-RNO-109539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Rattus norvegicus)
RHEA:59651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotriono-1,5-lactone + H2O <=> D-xylotrionate + H(+)
RHEA:36693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octadecanoylsphing-4-enine => octadecanoyl-CoA + sphing-4-enine
RHEA:69453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH => 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)
REACT:R-RNO-5694441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1D phosphorylates SEC23 (Rattus norvegicus)
REACT:R-DME-2730858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of BTK/ITK (Drosophila melanogaster)
RHEA:24424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione dehydrogenase (ascorbate)"
RHEA:24424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate
RHEA:24424	skos:prefLabel	"glutathione dehydrogenase (ascorbate)"
REACT:R-DRE-1977958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with ERBB3 (Danio rerio)
GO:0120086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-(+)-asterisca-2(9),6-diene synthase activity
GO:0120086	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	asterisca-2(9),6-diene synthase activity
REACT:R-DRE-202713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD84 homodimerises (Danio rerio)
REACT:R-MMU-5205682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin promotes the ubiquitination of mitochondrial substrates (Mus musculus)
RHEA:29103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+)(in) + menaquinone-8 + NADH = 4 H(+)(out) + menaquinol-8 + NAD(+)
REACT:R-BTA-9009541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds to TFF1 gene promoter (Bos taurus)
REACT:R-HSA-9690414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRY and NR5A1 (SF1) bind SOX9 gene (Homo sapiens)
REACT:R-PFA-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Plasmodium falciparum)
REACT:R-GGA-4420140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Gallus gallus)
REACT:R-HSA-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Homo sapiens)
REACT:R-SSC-9678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 binds S1PR1 agonists (Sus scrofa)
RHEA:63195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 <=> glycine betaine + 2 H(+) + phosphate
RHEA:61940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose = 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP
REACT:R-SCE-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Saccharomyces cerevisiae)
REACT:R-DRE-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Danio rerio)
REACT:R-SSC-8950456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B dimerizes (Sus scrofa)
REACT:R-HSA-2750187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Homo sapiens)
RHEA:56929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epiandrosterone 3-sulfate(out) + 2 Na(+)(out) = epiandrosterone 3-sulfate(in) + 2 Na(+)(in)
REACT:R-HSA-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Homo sapiens)
RHEA:21070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + nitrate => A + H2O + nitrite
REACT:R-XTR-174452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha on the C-strand of the telomere (Xenopus tropicalis)
RHEA:40008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O => (+)-copalol + diphosphate
REACT:R-CEL-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Caenorhabditis elegans)
REACT:R-DRE-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Danio rerio)
REACT:R-DME-9679740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)
REACT:R-SSC-5218830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates PTK2-beta (Sus scrofa)
REACT:R-DRE-5637686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Danio rerio)
REACT:R-HSA-180725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rev associates with B23 (Homo sapiens)
REACT:R-GGA-352864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose [extracellular] <=> glucose [cytosol] (Gallus gallus)
RHEA:29180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 2 O2 => a menaquinone + 2 H(+) + 2 superoxide
RHEA:28724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin(in) + H(+)(in) => (S)-allantoin(out) + H(+)(out)
REACT:R-BTA-202703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD47 binds SIRP (Bos taurus)
REACT:R-BTA-5218905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Bos taurus)
RHEA:43400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP
RHEA:63761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine
REACT:R-HSA-9033490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves PHYH (Homo sapiens)
GO:0070974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU domain binding
REACT:R-SPO-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)
REACT:R-HSA-8851679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR183 binds 7alpha,25-dihydroxycholesterol (Homo sapiens)
REACT:R-SSC-5358343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT palmitoylates Hh N-terminal fragment (Sus scrofa)
RHEA:31252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxyisobutanoyl-CoA + H2O => (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)
GO:0102813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity
RHEA:41352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine
RHEA:67831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine <=> a lipid A disaccharide + H(+) + UDP
RHEA:22697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + androst-4-ene-3,17-dione + O2 => A + H2O + testololactone
REACT:R-GGA-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Gallus gallus)
REACT:R-SPO-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-HSA-2220976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)
RHEA:22137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 => chlorophyllide b + 2 H2O + NADP(+)
REACT:R-SCE-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Saccharomyces cerevisiae)
EC:3.4.21.73	skos:prefLabel	"u-plasminogen activator"
EC:3.4.21.73	skos:altLabel	"cellular plasminogen activator"
EC:3.4.21.73	skos:altLabel	"urinary plasminogen activator"
EC:3.4.21.73	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"u-plasminogen activator"
EC:3.4.21.73	skos:altLabel	"urokinase"
REACT:R-XTR-114261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-7 by the apoptosome (Xenopus tropicalis)
REACT:R-BTA-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Bos taurus)
REACT:R-GGA-5635860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Gallus gallus)
RHEA:41857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydecanoyl-[ACP] + NADP(+)
RHEA:27409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX
RHEA:34797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O
RHEA:22009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine + succinyl-CoA => CoA + O-succinyl-L-homoserine
RHEA:39184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodocosanoyl-CoA + H(+) + NADPH => (3R)-hydroxydocosanoyl-CoA + NADP(+)
RHEA:45699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(acetyl)-sphing-4-enine-1-phosphate(in) <=> N-(acetyl)-sphing-4-enine-1-phosphate(out)
EC:4.2.1.9	skos:prefLabel	"dihydroxy-acid dehydratase"
EC:4.2.1.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroxy-acid dehydratase"
GO:0103092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthioalkylmalate isomerase activity
REACT:R-CEL-71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Caenorhabditis elegans)
REACT:R-CFA-5654397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS2 (Canis familiaris)
RHEA:63539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bradykinin(1-8) + H2O <=> bradykinin(1-7) + L-phenylalanine
REACT:R-XTR-9734070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET recombinant therapeutic antibodies bind MET (Xenopus tropicalis)
RHEA:45509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]
RHEA:29366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O <=> 2'-deoxycytidine + phosphate
REACT:R-BTA-209765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
GO:0070567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidylyltransferase activity
REACT:R-SSC-8981093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12 bound to IL12R internalises (Sus scrofa)
REACT:R-XTR-139898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 activates BID by cleavage (Xenopus tropicalis)
REACT:R-DME-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Drosophila melanogaster)
RHEA:51055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + A <=> 5alpha-androst-1-ene-3,17-dione + AH2
GO:0046911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal chelating activity
GO:0046911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal chelation
GO:0046911	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heavy metal chelation
REACT:R-MMU-6788611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYKK phosphorylates 5HLYS (Mus musculus)
RHEA:70331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetyl-CoA + H2O = 3-hydroxyphenylacetate + CoA + H(+)
REACT:R-CEL-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Caenorhabditis elegans)
GO:0047315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-kynurenine:glyoxylate aminotransferase (cyclizing)
GO:0047315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine-glyoxylate aminotransferase activity
GO:0047315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine-glyoxylate transaminase activity
GO:0047315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenine--glyoxylate aminotransferase activity
REACT:R-CFA-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Canis familiaris)
REACT:R-DRE-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)
EC:3.2.1.202	skos:altLabel	"endolytic chitodextrinase"
EC:3.2.1.202	skos:prefLabel	"endo-chitodextinase"
EC:3.2.1.202	skos:altLabel	"periplasmic chitodextrinase"
EC:3.2.1.202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endo-chitodextinase"
EC:3.2.1.202	skos:altLabel	"chitodextrinase"
REACT:R-MMU-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Mus musculus)
REACT:R-SCE-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Saccharomyces cerevisiae)
REACT:R-HSA-193832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)
RHEA:63049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pravastatin lactone => H(+) + pravastatin
REACT:R-SSC-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Sus scrofa)
REACT:R-MMU-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Mus musculus)
REACT:R-CEL-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-CFA-9008577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37:IL18R1 binds SIGIRR (Canis familiaris)
REACT:R-HSA-9694630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nsp3:nsp4 binds to nsp6 (Homo sapiens)
REACT:R-GGA-5687284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMBT1 binds SFTPD 12mer, SFTPAs (Gallus gallus)
REACT:R-XTR-193727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
RHEA:31650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate
RHEA:20188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CMP-N-acyl-beta-neuraminate + H2O <=> an N-acylneuraminate + CMP + H(+)
REACT:R-SSC-5578883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Sus scrofa)
RHEA:60446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteine + glycine => an S-substituted L-cysteinylglycine + H2O
REACT:R-DME-8877760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Drosophila melanogaster)
REACT:R-DDI-6799722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 oxidoreductase generates unstable semiquinones (Dictyostelium discoideum)
RHEA:14936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate
REACT:R-MMU-430073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Mus musculus)
REACT:R-HSA-193508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Homo sapiens)
REACT:R-CEL-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Caenorhabditis elegans)
REACT:R-CFA-997314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of JAK1 by SHP1 (Canis familiaris)
REACT:R-RNO-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Rattus norvegicus)
REACT:R-DRE-5638157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Danio rerio)
REACT:R-CFA-8948232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Canis familiaris)
RHEA:36264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyurea + O-acetyl-L-serine => acetate + H(+) + O-ureido-L-serine
REACT:R-BTA-5627071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Bos taurus)
REACT:R-CEL-3234094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TFAP2C with SUMO1 (Caenorhabditis elegans)
RHEA:23861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + deacetylcephalosporin C => cephalosporin C + CoA
GO:0051717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity
GO:0051717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity
GO:0051717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity
REACT:R-XTR-190326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 (Xenopus tropicalis)
RHEA:31781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O
REACT:R-DME-2161660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGE2 by PTGES (Drosophila melanogaster)
REACT:R-SSC-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Sus scrofa)
REACT:R-HSA-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Homo sapiens)
EC:3.4.17.16	skos:altLabel	"membrane Pro-X carboxypeptidase"
EC:3.4.17.16	skos:prefLabel	"membrane Pro-Xaa carboxypeptidase"
EC:3.4.17.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"membrane Pro-Xaa carboxypeptidase"
EC:3.4.17.16	skos:altLabel	"microsomal carboxypeptidase"
EC:3.4.17.16	skos:altLabel	"carboxypeptidase P"
RHEA:25272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline + S-adenosyl-L-methionine <=> (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine
RHEA:35392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA
REACT:R-SCE-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Saccharomyces cerevisiae)
RHEA:41582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate => 5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate
RHEA:59981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTP + H2O => 8-oxo-dGDP + H(+) + phosphate
RHEA:30103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-didehydro-D-gluconate + H(+) + NADH = 5-dehydro-D-gluconate + NAD(+)
REACT:R-CFA-2984226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NEK9 (Canis familiaris)
RHEA:57702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine
RHEA:16422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-164514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrase binds viral DNA ends (Homo sapiens)
REACT:R-HSA-211873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)
GO:0050374	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalacturonate decarboxylase activity
GO:0050374	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)
GO:0050374	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-galacturonate carboxy-lyase activity
GO:0050374	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galacturonic acid decarboxylase activity
GO:0050374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galacturonate decarboxylase activity
GO:0050374	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPGalUA carboxy lyase activity
REACT:R-SSC-1855162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Sus scrofa)
REACT:R-HSA-444792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)
RHEA:43301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP
REACT:R-CFA-5607723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
REACT:R-DRE-4085217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Danio rerio)
REACT:R-DME-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)
REACT:R-BTA-177944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)
RHEA:67973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + ecdysone => ADP + ecdysone 22-phosphate + H(+)
REACT:R-RNO-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)
REACT:R-HSA-9605056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3 (Homo sapiens)
REACT:R-SSC-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Sus scrofa)
RHEA:28314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baicalein + UDP-alpha-D-glucuronate = baicalin + UDP
REACT:R-HSA-4085028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE phosphorylates ManNAc to ManNAc-6-P (Homo sapiens)
REACT:R-BTA-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Bos taurus)
GO:0008738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fuculose-1-phosphate lactaldehyde-lyase activity
GO:0008738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuculose-phosphate aldolase activity
GO:0008738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)
GO:0008738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fuculose 1-phosphate aldolase activity
GO:0008738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fuculose aldolase activity
RHEA:42926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine
REACT:R-DRE-201475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with R-Smad1/5/8 for type I receptor (Danio rerio)
REACT:R-RNO-8853429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLDA1 binds AURKA (Rattus norvegicus)
REACT:R-RNO-2161620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by PTGDS (Rattus norvegicus)
REACT:R-SCE-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Saccharomyces cerevisiae)
RHEA:34152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine => 2-deoxystreptamine + 2-oxoglutaramate
REACT:R-DRE-5690827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 (Danio rerio)
REACT:R-BTA-373738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin interacts with syntenin-1 (Bos taurus)
GO:0033414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGC codon-amino acid adaptor activity
GO:0033414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine tRNA
GO:0033414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGC codon-amino acid adaptor activity
RHEA:39100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanedioyl-CoA + CoA => acetyl-CoA + octanedioyl-CoA
RHEA:21612	skos:prefLabel	"gluconate/galactonate dehydratase"
RHEA:21612	skos:prefLabel	"gluconate dehydratase"
RHEA:21612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gluconate dehydratase"
RHEA:21612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gluconate/galactonate dehydratase"
RHEA:21612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O
RHEA:21612	skos:altLabel	"gluconate dehydratase"
REACT:R-BTA-3769391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 binds the beta-catenin:CBY complex (Bos taurus)
RHEA:14535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine => creatinine + H2O
REACT:R-GGA-73739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Gallus gallus)
EC:2.8.3.25	skos:prefLabel	"bile acid CoA-transferase"
EC:2.8.3.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bile acid CoA-transferase"
EC:2.8.3.25	skos:altLabel	"bile acid coenzyme A transferase"
REACT:R-HSA-9028525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2 or NR1H3, NRIP1 bind the SREBF1 gene (Homo sapiens)
REACT:R-MMU-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Mus musculus)
REACT:R-SSC-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Sus scrofa)
EC:3.4.21.71	skos:prefLabel	"pancreatic elastase II"
EC:3.4.21.71	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pancreatic elastase II"
RHEA:14014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + taurolithocholate => adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate
RHEA:30035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 = benzene-1,2,4-triol + CO2 + H2O + NAD(+)
RHEA:32642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-445085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of VAV2 (Homo sapiens)
REACT:R-DME-1296127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of voltage gated Potassium channels (Drosophila melanogaster)
RHEA:18338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + uracil => H2O + psi-UMP
RHEA:65802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine => a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O
REACT:R-XTR-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Xenopus tropicalis)
REACT:R-DRE-5687360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLL or POLM extends aligned DNA DSB ends to fill gaps (Danio rerio)
RHEA:46435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-446083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD151 interacts with BP180 and the integrin alpha 6 subunit (Rattus norvegicus)
RHEA:72204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(out) + hydrogencarbonate(in) => 2 chloride(in) + hydrogencarbonate(out)
RHEA:22104	skos:altLabel	"NAAT"
RHEA:22104	skos:altLabel	"NAAT-I"
RHEA:22104	skos:altLabel	"NAAT-III"
RHEA:22104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotianamine aminotransferase"
RHEA:22104	skos:prefLabel	"nicotianamine aminotransferase"
RHEA:22104	skos:altLabel	"NAAT-II"
RHEA:22104	skos:altLabel	"nicotianamine transaminase"
RHEA:22104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate
RHEA:48593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + formate + H(+) => a quinol + CO2
RHEA:66039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate
REACT:R-RNO-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Rattus norvegicus)
REACT:R-BTA-8984012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Bos taurus)
REACT:R-CFA-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Canis familiaris)
RHEA:28171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-2-methylbutanenitrile => butan-2-one + hydrogen cyanide
RHEA:57415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-tyrosinal + NADP(+) <=> ATP + H(+) + L-tyrosine + NADPH
REACT:R-BTA-1462023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-pro-defensins are cleaved to remove the signal peptide (Bos taurus)
REACT:R-RNO-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Rattus norvegicus)
REACT:R-SCE-70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Saccharomyces cerevisiae)
RHEA:55133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanine + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate
REACT:R-XTR-5690790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H2A is dubiquitinated by the PR-DUB complex (Xenopus tropicalis)
RHEA:34632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]
RHEA:20682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-cis-zeatin + UDP
REACT:R-XTR-1605736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Xenopus tropicalis)
REACT:R-DRE-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Danio rerio)
RHEA:50510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-valyl-[protein]
RHEA:46795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0016842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amidine-lyase activity
GO:0016842	skos:prefLabel	"Lyases acting on amides, amidines, etc"
GO:0016842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Lyases acting on amides, amidines, etc"
REACT:R-HSA-9709852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)
EC:2.1.1.291	skos:prefLabel	"(R,S)-reticuline 7-O-methyltransferase"
EC:2.1.1.291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R,S)-reticuline 7-O-methyltransferase"
REACT:R-HSA-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Homo sapiens)
RHEA:45702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + N,N-dimethylglycine + NAD(+) => glycine betaine + H(+) + NADH + O2
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rab interactor activity
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rab escort protein activity
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GTP-Ral binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ran protein binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ras interactor activity
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small GTPase binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ras GTPase binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	REP
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ADP-ribosylation factor binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ran GTPase binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rho GTPase binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ran-binding protein
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ARF binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GTP-Rho binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rab GTPase binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rac GTPase binding
GO:0031267	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ral GTPase binding
RHEA:50442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D1 => prostaglandin H1
RHEA:62564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + A + H2O = (4S)-perillyl alcohol + AH2
REACT:R-DRE-202917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 1 (Danio rerio)
REACT:R-MMU-9718360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide agonists (Mus musculus)
REACT:R-RNO-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Rattus norvegicus)
RHEA:26564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoyl-CoA + H2O => 2-succinylbenzoyl-CoA + H(+)
REACT:R-XTR-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Xenopus tropicalis)
REACT:R-CFA-198870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-GGA-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Gallus gallus)
REACT:R-HSA-8851710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant (Homo sapiens)
RHEA:45994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + H2O => (3R)-3-hydroxydecanoyl-CoA
REACT:R-DME-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Drosophila melanogaster)
RHEA:36089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O
RHEA:52114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA
REACT:R-BTA-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Bos taurus)
REACT:R-MMU-390251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Mus musculus)
REACT:R-SSC-77309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Sus scrofa)
RHEA:31688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 => (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate
REACT:R-BTA-8851979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL9 binds immune cell surfaces (Bos taurus)
RHEA:58276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 ATP = cyclic hexaadenylate + 6 diphosphate
RHEA:29716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate + FMNH2 + O2 => FMN + glycolaldehyde + 2 H(+) + H2O + sulfite
REACT:R-XTR-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Xenopus tropicalis)
REACT:R-CFA-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Canis familiaris)
REACT:R-MMU-2396606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)
RHEA:56002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
RHEA:45135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
REACT:R-HSA-912727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds VAV (Homo sapiens)
RHEA:43145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(22) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine
GO:0022851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA-gated chloride ion channel activity
RHEA:65606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + eicosanoyl-CoA
REACT:R-MMU-1247668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A binds O2, releasing H+ and CO2 (Mus musculus)
REACT:R-GGA-3134953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 or DHX9 binds MyD88 (Gallus gallus)
RHEA:55587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in mRNA + S-adenosyl-L-methionine <=> an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-5628905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Gallus gallus)
REACT:R-RNO-114254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS binds to APAF1 (Rattus norvegicus)
RHEA:44958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + NADP(+) => (2E)-hexenoyl-CoA + H(+) + NADPH
REACT:R-HSA-3240766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1/2/3:DP1/2 binds SUZ12 gene promoter (Homo sapiens)
RHEA:55308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
RHEA:71566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminomethyl-dUMP in DNA + acetyl-CoA <=> 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)
REACT:R-DME-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Drosophila melanogaster)
REACT:R-HSA-2731122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2 & 4 bind VTN (Homo sapiens)
RHEA:59357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lactobiono-1,5-lactone => H(+) + lactobionate
REACT:R-BTA-433104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACT co-transports trivalent citrate and a sodium ion (Bos taurus)
RHEA:17564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine + H2O <=> acetate + choline + H(+)
RHEA:16314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)
REACT:R-BTA-1236956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfment of particulate antigen into phagocytic vesicle (Bos taurus)
RHEA:27875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochorismate => pyruvate + salicylate
RHEA:72583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) = 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH
REACT:R-MMU-2130725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of MHC II:Ii clathrin coated vesicle (Mus musculus)
RHEA:66687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] <=> L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]
RHEA:35517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + salvianin => 4'''-demalonylsalvianin + malonyl-CoA
REACT:R-MMU-5654615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:pFRS binds GRB2:SOS1 (Mus musculus)
REACT:R-DRE-9718020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PTGFR agonists (Danio rerio)
REACT:R-DME-5654659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
GO:0102434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pterin-4alpha-carbinolamine dehydratase activity
RHEA:14949	skos:prefLabel	"quinoline-4-carboxylate 2-oxidoreductase"
RHEA:14949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinoline-4-carboxylate 2-oxidoreductase"
RHEA:14949	skos:altLabel	"quinoline-4-carboxylic acid 2-oxidoreductase"
RHEA:14949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2
RHEA:14949	skos:altLabel	"quinaldic acid 4-oxidoreductase"
RHEA:49895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 <=> (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2
REACT:R-MMU-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Mus musculus)
REACT:R-CEL-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Caenorhabditis elegans)
RHEA:28459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin(in) => biotin(out)
RHEA:17103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + a fatty acid + H(+) => H2O + O-acyl-(R)-carnitine
REACT:R-SSC-378956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone is a heterodimer (Sus scrofa)
RHEA:64873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 1-phosphate => dihydroxyacetone phosphate + glycolaldehyde
REACT:R-RNO-6804485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates L3MBTL2 with SUMO2 (Rattus norvegicus)
REACT:R-HSA-2404200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2 binds IGF1R (Homo sapiens)
RHEA:28922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) + L-glutamate(out) <=> 4-aminobutanoate(out) + L-glutamate(in)
REACT:R-XTR-201515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK recruits PI3K (Xenopus tropicalis)
REACT:R-BTA-167429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex  binds GTP (Bos taurus)
REACT:R-DDI-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Dictyostelium discoideum)
REACT:R-DRE-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Danio rerio)
REACT:R-HSA-2467659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds NCAM1, PTPRS (Homo sapiens)
REACT:R-DME-9759209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2 binds extracellular TCN2:RCbl (Drosophila melanogaster)
REACT:R-MMU-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)
REACT:R-GGA-1006169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds host cell surface markers (Gallus gallus)
EC:1.3.1.124	skos:altLabel	"Delta(2),Delta(4)-dienoyl-CoA reductase"
EC:1.3.1.124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]"
EC:1.3.1.124	skos:prefLabel	"2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]"
RHEA:54331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-[ACP] + 2 NADPH <=> hexadecan-1-ol + holo-[ACP] + 2 NADP(+)
REACT:R-SCE-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Saccharomyces cerevisiae)
REACT:R-SSC-9619756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2 binds ABCA1 (Sus scrofa)
REACT:R-SSC-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Sus scrofa)
REACT:R-DME-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
REACT:R-DRE-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Danio rerio)
REACT:R-GGA-190782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of connexon-containing transport vesicles from the Golgi (Gallus gallus)
REACT:R-GGA-451511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR15 binds to recognized ligand (Gallus gallus)
REACT:R-GGA-265894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRIP1 (FANCJ) helicase functions in direct unwinding of DNA (Gallus gallus)
RHEA:25467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + longifolene
REACT:R-DRE-8876837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB21 GEFs exchange GTP for GDP on RAB21 (Danio rerio)
RHEA:50385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline => 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-DME-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Drosophila melanogaster)
RHEA:56501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3,5-bisphosphomevalonate + H(+) => CO2 + isopentenyl phosphate + phosphate
RHEA:17546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] => [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]
REACT:R-HSA-909738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 bind the common beta chain (Homo sapiens)
RHEA:12853	skos:altLabel	"UDP-glucose-p-hydroxymandelonitrile glucosyltransferase"
RHEA:12853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanohydrin beta-glucosyltransferase"
RHEA:12853	skos:altLabel	"uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase"
RHEA:12853	skos:altLabel	"UGT85B1"
RHEA:12853	skos:altLabel	"uridine diphosphoglucose-cyanohydrin glucosyltransferase"
RHEA:12853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose = dhurrin + H(+) + UDP
RHEA:12853	skos:prefLabel	"cyanohydrin beta-glucosyltransferase"
REACT:R-BTA-8854736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 binds FLT3 (Bos taurus)
RHEA:62317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylate + UDP-alpha-D-glucose => 1-O-salicyl-beta-D-glucose + UDP
RHEA:69924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	castasterone + O2 + reduced [NADPH--hemoprotein reductase] => brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Gallus gallus)
RHEA:28364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + diphosphate + H(+) => dGTP + H2O
GO:0102395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-beta-carotene 9',10'-cleavage oxygenase activity
GO:0043333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity
GO:0043333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
RHEA:11543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine + NAD(+) <=> an N-acyl-D-mannosaminolactone + H(+) + NADH
REACT:R-CFA-8864307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Canis familiaris)
REACT:R-DME-373732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin trans-homophilic interaction (Drosophila melanogaster)
RHEA:52962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyocholoyl-24-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate
REACT:R-DDI-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Dictyostelium discoideum)
RHEA:71742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate(in) + 2-oxoglutarate(out) <=> 2-oxoadipate(out) + 2-oxoglutarate(in)
GO:0000140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl dihydroxyacetone phosphate reductase activity
GO:0000140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyldihydroxyacetone-phosphate reductase activity
GO:0000140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl-dihydroxyacetone-phosphate reductase activity
GO:0000140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity
GO:0000140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyldihydroxyacetone-phosphate reductase activity
GO:0000140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylglycerone-phosphate reductase activity
GO:0000140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyldihydroxyacetone phosphate reductase activity
RHEA:30532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinate sulfoxide + H(+) + NADH => biotin + H2O + NAD(+)
RHEA:12665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminoglycoside N(3)-acetyltransferase"
RHEA:12665	skos:altLabel	"aminoglycoside 3-N-acetyltransferase"
RHEA:12665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)
RHEA:12665	skos:altLabel	"3-aminoglycoside acetyltransferase"
RHEA:12665	skos:prefLabel	"aminoglycoside N(3)-acetyltransferase"
RHEA:38277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + pyruvate => (3R)-citramalyl-CoA
RHEA:72679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)
GO:0005227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium activated cation channel activity
GO:0005227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intracellular calcium-activated potassium channel
GO:0005227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	polycystin
REACT:R-RNO-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Rattus norvegicus)
REACT:R-SSC-9632906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ recruits RAS in response to estrogen stimulation (Sus scrofa)
REACT:R-XTR-5334794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABPs bind LCFAs (Xenopus tropicalis)
REACT:R-BTA-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Bos taurus)
REACT:R-DRE-417829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds ADP (Danio rerio)
REACT:R-RNO-5654422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS2 (Rattus norvegicus)
RHEA:20910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate
GO:0070990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP binding
REACT:R-DME-264615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Drosophila melanogaster)
RHEA:26233	skos:prefLabel	"geranylgeraniol 18-hydroxylase"
RHEA:26233	skos:altLabel	"GGOH-18-hydroxylase"
RHEA:26233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol
RHEA:26233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranylgeraniol 18-hydroxylase"
RHEA:46507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-AMP + holo-[ACP] <=> AMP + dodecanoyl-[ACP] + H(+)
GO:0019207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinase regulator activity
REACT:R-HSA-5099886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)
RHEA:18737	skos:altLabel	"Selenium donor protein"
RHEA:18737	skos:altLabel	"Selenide,water dikinase"
RHEA:18737	skos:altLabel	"selenophosphate synthase"
RHEA:18737	skos:altLabel	"Selenophosphate synthetase"
RHEA:18737	skos:prefLabel	"selenide, water dikinase"
RHEA:18737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate
RHEA:18737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"selenide, water dikinase"
REACT:R-BTA-8852522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 dimer:MST1R dimer binds MST1R dimer (Bos taurus)
GO:0102901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopimaradienol hydroxylase activity
REACT:R-SPO-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Schizosaccharomyces pombe)
GO:0102655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity
REACT:R-BTA-8938300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vanin hydrolyses pantetheine to PanK, 2AET (Bos taurus)
REACT:R-SSC-1614362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Sus scrofa)
RHEA:42665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-arabinopyanose + NADP(+) => H(+) + L-arabinono-1,4-lactone + NADPH
RHEA:50986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E2(in) => prostaglandin E2(out)
REACT:R-CEL-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Caenorhabditis elegans)
GO:0052755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420H2:quinone oxidoreductase activity
GO:0052755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced coenzyme F420:quinone oxidoreductase activity
GO:0052755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420H2:2,3-dimethyl-1,4-naphthoquinone oxidoreductase activity
GO:0052755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420H2-dependent quinone oxidoreductase activity
RHEA:42411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate + ATP <=> (2R)-2,3-bisphosphoglycerate + ADP + H(+)
REACT:R-HSA-8985343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SOX9 (Homo sapiens)
RHEA:24515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + H2O
RHEA:28973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + shikimate(out) => H(+)(in) + shikimate(in)
REACT:R-DRE-1475025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Danio rerio)
REACT:R-CFA-2731141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds fibronectin (Canis familiaris)
REACT:R-MMU-352136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Mus musculus)
REACT:R-SSC-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Sus scrofa)
REACT:R-MMU-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Mus musculus)
REACT:R-MMU-189384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLVRA:Zn2+, BLVRB reduce BV to BIL (Mus musculus)
REACT:R-HSA-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Homo sapiens)
REACT:R-DDI-9635739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)
GO:0019196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosamine porter activity
GO:0019196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosamine transmembrane transporter activity
RHEA:60830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate => a 5'-end triphospho-adenosine in mRNA + H2O
RHEA:72059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate(out) + 2 Na(+)(out) = glycochenodeoxycholate(in) + 2 Na(+)(in)
RHEA:66163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + tyramine <=> CoA + H(+) + N-hexanoyltyramine
REACT:R-BTA-6807118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)
RHEA:27314	skos:prefLabel	"dichloroarcyriaflavin A synthase"
RHEA:27314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 = 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)
RHEA:27314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dichloroarcyriaflavin A synthase"
RHEA:67447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-hydroxy-long-chain-fatty acyl-CoA <=> a long-chain fatty aldehyde + formyl-CoA
REACT:R-XTR-2028555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Xenopus tropicalis)
RHEA:57363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADH <=> (6R)-NADHX
REACT:R-DRE-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Danio rerio)
REACT:R-DRE-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Danio rerio)
RHEA:47740	skos:altLabel	"1,4-diketo-2-naphthoate phytyltransferase"
RHEA:47740	skos:altLabel	"1,4-dioxo-2-naphthoate phytyltransferase"
RHEA:47740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate = CO2 + demethylphylloquinone + diphosphate
RHEA:47740	skos:prefLabel	"2-carboxy-1,4-naphthoquinone phytyltransferase"
RHEA:47740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-carboxy-1,4-naphthoquinone phytyltransferase"
REACT:R-RNO-8875661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA3 associates with activated MET receptor (Rattus norvegicus)
REACT:R-HSA-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Homo sapiens)
RHEA:34369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylate + NH4(+) => acrylamide + H2O
REACT:R-MMU-159443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Mus musculus)
RHEA:32005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + isopimara-8(14),15-diene => (+)-copalyl diphosphate
RHEA:50815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9014434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GAPs stimulate RHOG GTPase activity (Homo sapiens)
REACT:R-DME-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Drosophila melanogaster)
RHEA:59009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + salicylaldehyde => H(+) + H2O2 + salicylate
RHEA:25514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + L-glutamine => (2S)-2-amino-4-deoxychorismate + L-glutamate
REACT:R-SSC-8987040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Sus scrofa)
REACT:R-HSA-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Homo sapiens)
RHEA:49379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + bisphenol A => adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)
RHEA:57609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-chlorocatechol + H(+) + NADH
REACT:R-DDI-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Dictyostelium discoideum)
REACT:R-RNO-983138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC heterotrimer to ER exit site (Rattus norvegicus)
RHEA:38062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA <=> 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
RHEA:57121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
RHEA:45797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH
RHEA:58432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-oxonon-2-en-1-ol + NADP(+) = (E)-4-oxonon-2-enal + H(+) + NADPH
RHEA:58602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2
RHEA:38396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)
REACT:R-MMU-1650808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Mus musculus)
RHEA:17814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-altronate + NAD(+) => H(+) + keto-D-tagaturonate + NADH
REACT:R-DME-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Drosophila melanogaster)
RHEA:43734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O
GO:0016695	skos:prefLabel	"Acting on hydrogen as donors"
GO:0016695	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on hydrogen as donor, other acceptors
GO:0016695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on hydrogen as donor
GO:0016695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on hydrogen as donors"
REACT:R-BTA-388814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds CD28 (Bos taurus)
REACT:R-GGA-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Gallus gallus)
GO:0052585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor
GO:0052585	skos:prefLabel	"With a quinone or similar compound as acceptor"
GO:0052585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
REACT:R-HSA-9022465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 mutants R106W, D121G, R133H, S134F, T158M and T158A do not bind to 5mC-DNA (Homo sapiens)
RHEA:11088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trimetaphosphate = 2 H(+) + triphosphate
RHEA:11088	skos:prefLabel	"trimetaphosphatase"
RHEA:11088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trimetaphosphatase"
REACT:R-MMU-2395849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
RHEA:61185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercitrin + UDP-beta-L-rhamnose => H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP
REACT:R-BTA-5686587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates RAD52 (Bos taurus)
REACT:R-CFA-380311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Plk1 to centrosomes (Canis familiaris)
REACT:R-MMU-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Mus musculus)
REACT:R-DRE-9033533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Danio rerio)
REACT:R-HSA-5662621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1M binds zinc (Homo sapiens)
REACT:R-HSA-6790487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
RHEA:33549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + lanosterol => H2O + lanosteryl hexadecanoate
RHEA:58197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[histone] => acetate + L-lysyl-[histone]
RHEA:71693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamate(in) + 2 H(+)(in) => glycyl-L-glutamate(out) + 2 H(+)(out)
REACT:R-MMU-2168884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Methemoglobin to Hemopexin (Mus musculus)
REACT:R-RNO-5610767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Rattus norvegicus)
GO:0044323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RARE binding
GO:0044323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinoic acid-responsive element binding
RHEA:66281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solanidine + UDP-alpha-D-glucose => H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP
REACT:R-SSC-6814764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasma membrane resorption (Sus scrofa)
GO:0043916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-7-methylguanine glycosylase activity
REACT:R-HSA-390909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds hist (Homo sapiens)
GO:0047547	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity
GO:0047547	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methylcitrate hydro-lyase activity
GO:0047547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylcitrate dehydratase activity
GO:0047547	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prpD
GO:0047547	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]
REACT:R-BTA-4420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 disassociates from VEGFR2 and translocate to PM (Bos taurus)
REACT:R-BTA-8986258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2:ROBO1 binds CXCR4 (Bos taurus)
REACT:R-GGA-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Gallus gallus)
RHEA:53353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20b) in tRNA + NAD(+) => H(+) + NADH + uridine(20b) in tRNA
RHEA:23597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate
REACT:R-SSC-9735946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET small tyrosine kinase inhibitors bind MET (Sus scrofa)
RHEA:21434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + oxaloacetate => (S)-malate + NAD(+)
RHEA:63686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,5S)-dethiobiotin + ADP + H(+) + phosphate => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP
REACT:R-BTA-9029667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DFF dissociates from importin-alpha:importin-beta (Bos taurus)
RHEA:35509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:49622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose 1-phosphate + H(+) + NADPH => D-erythritol 1-phosphate + NADP(+)
REACT:R-DDI-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Dictyostelium discoideum)
REACT:R-BTA-917891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Bos taurus)
GO:0140487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal ion sequestering activity
RHEA:49751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NADP(+) + proviolacein
RHEA:62090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH => D-glucosamine 6-phosphate + NADP(+)
RHEA:51927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + menaquinone-9 <=> A + beta-dihydromenaquinone-9
REACT:R-CEL-8944225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVII (Caenorhabditis elegans)
GO:0050048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine-alpha-ketoglutarate transaminase activity
GO:0050048	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-leucine aminotransferase activity
GO:0050048	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	leucine aminotransferase activity
GO:0050048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine 2-oxoglutarate transaminase activity
GO:0050048	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	leucine transaminase activity
GO:0050048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine:2-oxoglutarate aminotransferase activity
RHEA:56026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)
REACT:R-HSA-210304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)
REACT:R-HSA-8944240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type III (Homo sapiens)
EC:1.3.99.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinoline 2-oxidoreductase"
EC:1.3.99.17	skos:prefLabel	"quinoline 2-oxidoreductase"
RHEA:27540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde => ethanol + N,N-dimethyl-4-nitrosoaniline
RHEA:43005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-carbamoyl-L-serine => 2-aminoprop-2-enoate + CO2 + NH4(+)
REACT:R-SCE-3322016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)
RHEA:70314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
REACT:R-DRE-6782224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' incision by ERCC5 (XPG) in TC-NER (Danio rerio)
REACT:R-PFA-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)
REACT:R-DME-9033520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves TYSND1 (Drosophila melanogaster)
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphocholine glyceride transferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-2-acetylglycerol cholinephosphotransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-1,2-diacylglycerol cholinephosphotransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylacylglycerol cholinephosphotransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol cholinephosphotransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPT
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylcholine--glyceride transferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphorylcholine diglyceride transferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-choline diglyceride phosphotransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphocholine diacylglyceroltransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylacylglycerol choline phosphotransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Homo sapiens)
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholinephosphotransferase activity
GO:0004142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diacylglycerol choline phosphotransferase activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate (Si)-synthase activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxaloacetate transacetase activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrogenase activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citric synthase activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate oxaloacetate-lyase, CoA-acetylating activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate synthetase activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalacetic transacetase activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate condensing enzyme activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	citrate synthase activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-citric synthase activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	condensing enzyme activity
GO:0004108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citric-condensing enzyme activity
REACT:R-GGA-9712210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Gallus gallus)
REACT:R-XTR-5691381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYSM1 deubiquitinates Histone H2A (Xenopus tropicalis)
RHEA:34790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH
EC:3.4.11.25	skos:prefLabel	"beta-peptidyl aminopeptidase"
EC:3.4.11.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-peptidyl aminopeptidase"
EC:3.4.24.37	skos:prefLabel	"saccharolysin"
EC:3.4.24.37	skos:altLabel	"proteinase yscD"
EC:3.4.24.37	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"saccharolysin"
EC:3.4.24.37	skos:altLabel	"oligopeptidase yscD"
EC:3.4.24.37	skos:altLabel	"yeast cysteine proteinase D"
RHEA:63894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + D-tryptophan + diphosphate + H(+) => ATP + H2O + L-tryptophan
REACT:R-PFA-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Plasmodium falciparum)
REACT:R-MMU-933533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of p-IRF7 (Mus musculus)
RHEA:10180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formyltetrahydrofolate dehydrogenase"
RHEA:10180	skos:altLabel	"10-formyltetrahydrofolate dehydrogenase"
RHEA:10180	skos:prefLabel	"formyltetrahydrofolate dehydrogenase"
RHEA:10180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH
RHEA:23553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropane-1,2-diol + NAD(+) => 2-hydroxy-2-methylpropanal + H(+) + NADH
RHEA:35208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IDP => H(+) + IMP + phosphate
RHEA:43330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP
RHEA:35593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + (n-1) sulfur => H2 + n sulfur
RHEA:56105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 => 4,4'-diaponeurosporenal + 2 A + 3 H2O
REACT:R-BTA-8852200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of LCK by PTPN22 (Bos taurus)
RHEA:25641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-menthone + NADP(+) = (R)-pulegone + H(+) + NADPH
RHEA:25641	skos:prefLabel	"(+)-pulegone reductase"
RHEA:25641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-pulegone reductase"
RHEA:25641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,5R)-isomenthone + NADP(+) = (R)-pulegone + H(+) + NADPH
REACT:R-HSA-5662598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds zinc (Homo sapiens)
RHEA:23908	skos:altLabel	"methionine synthase reductase"
RHEA:23908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine = 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine
RHEA:23908	skos:altLabel	"methionine synthase cob(II)alamin reductase (methylating)"
RHEA:23908	skos:altLabel	"[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)"
RHEA:23908	skos:prefLabel	"[methionine synthase] reductase"
RHEA:23908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[methionine synthase] reductase"
REACT:R-SCE-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Saccharomyces cerevisiae)
RHEA:11661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O => acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol
REACT:R-GGA-438026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation and dimerization of c-JUN in the nucleus (Gallus gallus)
REACT:R-XTR-166753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C4 into C4a and C4b (Xenopus tropicalis)
REACT:R-DRE-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Danio rerio)
REACT:R-GGA-9009817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acitretin binds to RAR:RXR (Gallus gallus)
REACT:R-MMU-5617182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates PLN (Mus musculus)
RHEA:50548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E1 = H2O + prostaglandin A1
REACT:R-DRE-450580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 (hnRNP D0) is ubiquitinylated (Danio rerio)
REACT:R-MMU-8874718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA binds alpha-TOH (Mus musculus)
GO:0047588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-aminopentanamidase"
GO:0047588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminopentanamide amidohydrolase activity
GO:0047588	skos:prefLabel	"5-aminopentanamidase"
GO:0047588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminonorvaleramidase activity
GO:0047588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanamidase activity
GO:0047588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminovaleramidase activity
GO:0047588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanamide + H2O = 5-aminopentanoate + NH4(+)
GO:0047588	skos:altLabel	"5-aminovaleramidase"
REACT:R-MMU-427656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-CFA-9010646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP5 recruits PKC to ROBO3.1 (Canis familiaris)
GO:0140282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-nitrogen ligase activity on lipid II
GO:0140282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate--lipid II transaminase activity
GO:0140282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl pentapeptide amidotransferase (glutamine-hydrolyzing) activity
REACT:R-SSC-5668947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates myosin phosphatase (Sus scrofa)
RHEA:40571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-RNO-9021520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds WWP2 (Rattus norvegicus)
REACT:R-DRE-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Danio rerio)
REACT:R-HSA-6797961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHDH oxidises Cho to BETALD (Homo sapiens)
RHEA:18095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + uracil => 5,6-dihydrouracil + NADP(+)
RHEA:16553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] = H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]
REACT:R-DRE-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)
REACT:R-RNO-9701507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN6 dephosphorylates JAK3 (Rattus norvegicus)
REACT:R-BTA-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Bos taurus)
REACT:R-XTR-9759154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM21 ubiquitinates SQSTM1 (Xenopus tropicalis)
RHEA:10035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal-L-glutamine + H2O <=> [protein]-C-terminal-L-glutamate + NH4(+)
REACT:R-HSA-168947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand binds to TLR10 (Homo sapiens)
REACT:R-CEL-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Caenorhabditis elegans)
RHEA:10904	skos:prefLabel	"cypemycin cysteine dehydrogenase (decarboxylating)"
RHEA:10904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A = AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide
RHEA:10904	skos:altLabel	"cypemycin decarboxylase"
RHEA:10904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cypemycin cysteine dehydrogenase (decarboxylating)"
RHEA:69802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophanyl-tRNA(Trp) + H2O <=> D-tryptophan + tRNA(Trp)
REACT:R-MMU-6797961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHDH oxidises Cho to BETALD (Mus musculus)
REACT:R-DRE-187020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of pro-beta-NGF is processed to mature beta-NGF (Danio rerio)
RHEA:53835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 <=> a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate
RHEA:15631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin] => a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-DME-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Drosophila melanogaster)
REACT:R-SSC-727819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 phosphorylates MKK6 (Sus scrofa)
RHEA:47915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-gluconate <=> 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O
REACT:R-HSA-844619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIM2 binds dsDNA (Homo sapiens)
REACT:R-HSA-158784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Homo sapiens)
REACT:R-BTA-200318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Bos taurus)
GO:0047213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity
GO:0047213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-GT activity
GO:0047213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanidin 3-O-glucosyltransferase activity
GO:0047213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin + H(+) + UDP-alpha-D-glucose = an anthocyanidin 3-O-beta-D-glucoside + UDP
GO:0047213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:cyanidin-3-O-glucosyltransferase activity
GO:0047213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity
GO:0047213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity
GO:0047213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity
REACT:R-BTA-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Bos taurus)
REACT:R-MMU-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Mus musculus)
REACT:R-DME-433131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC1 co-transports dicarboxylic acids and a sodium ion (Drosophila melanogaster)
REACT:R-XTR-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Xenopus tropicalis)
RHEA:33956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIBOA + UDP-alpha-D-glucose => DIBOA beta-D-glucoside + H(+) + UDP
REACT:R-BTA-8869694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds CD14 (Bos taurus)
REACT:R-DRE-174551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of alternative pathway C5 convertase (Danio rerio)
REACT:R-XTR-193766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
RHEA:44478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine
REACT:R-HSA-5635861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH binds GLI1 (Homo sapiens)
REACT:R-HSA-8961874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR gene expression is stimulated by E2F1 (Homo sapiens)
REACT:R-CFA-398040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma activation of PLC beta (Canis familiaris)
REACT:R-MMU-1296037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with large conductance (Mus musculus)
REACT:R-BTA-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Bos taurus)
REACT:R-SPO-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Schizosaccharomyces pombe)
REACT:R-HSA-9692250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)
RHEA:72644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine
REACT:R-MMU-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Mus musculus)
GO:0031406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxylic acid binding
REACT:R-XTR-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Xenopus tropicalis)
RHEA:13834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + pyruvate => 5-guanidino-2-oxopentanoate + L-alanine
GO:0097363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-GlcNAc transferase
GO:0097363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase
GO:0097363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein O-acetylglucosaminyltransferase activity
GO:0097363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein O-GlcNAc transferase activity
GO:0097363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGTase
GO:0097363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-linked N-acetylglucosaminyltransferase
RHEA:10118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + D-ribulose 5-phosphate + NADPH => 6-phospho-D-gluconate + NADP(+)
REACT:R-BTA-190388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3c (Bos taurus)
RHEA:36721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexacosenoylsphinganine => hexacosenoyl-CoA + sphinganine
REACT:R-DME-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Drosophila melanogaster)
RHEA:51699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethylxanthohumol + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + xanthohumol
REACT:R-XTR-2002460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB binds Collagen chains (Xenopus tropicalis)
RHEA:33883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-scyllo-inosamine + NAD(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH
RHEA:44520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-BTA-6809393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filaments bind cell-cell adhesion complexes (Bos taurus)
REACT:R-BTA-140825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)
RHEA:23957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
REACT:R-DRE-6803523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Danio rerio)
EC:7.2.4.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Linked to decarboxylation"
EC:7.2.4.-	skos:prefLabel	"Linked to decarboxylation"
REACT:R-RNO-213175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 oxidise AFB1 to AFXBO (Rattus norvegicus)
RHEA:55246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2
REACT:R-BTA-5693566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 associates with H4K20Me2 at DNA DSBs (Bos taurus)
RHEA:10279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
REACT:R-GGA-5357828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8 (Gallus gallus)
REACT:R-MMU-9021306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds and inactivates C1r, C1s (Mus musculus)
REACT:R-MMU-9634861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT2 (Mus musculus)
GO:0016232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNK-1 sulfotransferase activity
GO:0016232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Homo sapiens)
GO:0016232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNK-1 sulphotransferase activity
RHEA:17535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic oxo-acid + L-glutamate => 2-oxoglutarate + an aromatic L-alpha-amino acid
REACT:R-MMU-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)
RHEA:67331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione <=> trichosetin
REACT:R-RNO-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Rattus norvegicus)
RHEA:40492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)
RHEA:72601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-aspartyl-L-glutamate(in) => N-acetyl-L-aspartyl-L-glutamate(out)
RHEA:42141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine
REACT:R-HSA-2730889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)
RHEA:70588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetate + alpha-D-glucosaminyl-[heparan sulfate](n)
RHEA:43032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-D-alanine = 2-aminoprop-2-enoate + chloride + H(+)
REACT:R-MMU-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Mus musculus)
RHEA:20591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein] => glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-DME-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Drosophila melanogaster)
REACT:R-DDI-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Dictyostelium discoideum)
RHEA:43434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) => butan-1-ol + 2 Fe(III)-[cytochrome c]
REACT:R-RNO-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-DRE-193424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)
RHEA:29807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-leucine(out) = ADP + H(+) + L-leucine(in) + phosphate
RHEA:69036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-androstane-3,17-dione + H(+) + NADPH = 3beta-hydroxy-5beta-androstane-17-one + NADP(+)
REACT:R-RNO-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)
REACT:R-MMU-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Mus musculus)
REACT:R-GGA-198955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR complex interacts with peptide antigen-presenting MHC Class I (Gallus gallus)
REACT:R-SSC-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Sus scrofa)
REACT:R-RNO-9758604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
REACT:R-SSC-389354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Vav1 (Sus scrofa)
RHEA:43832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
RHEA:50421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] => H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)
RHEA:11577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine => AMP + H(+) + thiamine diphosphate
REACT:R-BTA-202233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Lck by Csk (Bos taurus)
REACT:R-MMU-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Mus musculus)
RHEA:60029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => 4-terpineol + diphosphate
RHEA:44419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)
REACT:R-XTR-417890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y5 receptor can bind to LPA (Xenopus tropicalis)
REACT:R-DME-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Drosophila melanogaster)
RHEA:23745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidinol phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
RHEA:62050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-CEL-1655851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2P hydrolyzes SREBP1A,1C,2 (Caenorhabditis elegans)
REACT:R-CFA-211206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of DFF to the nucleus (Canis familiaris)
REACT:R-GGA-977238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR5/TLR15 homodimer recruits MyD88 adaptor (Gallus gallus)
REACT:R-RNO-9688838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds STUB1 (Rattus norvegicus)
REACT:R-DME-8878050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 and EP300 (Drosophila melanogaster)
REACT:R-MMU-2161917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15S-HpETE to LXA4/B4 (Mus musculus)
REACT:R-HSA-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Homo sapiens)
REACT:R-HSA-1449687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticosteroids bind to CBG in blood (Homo sapiens)
REACT:R-MMU-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Mus musculus)
RHEA:68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (Z)-beta-ocimene + diphosphate
REACT:R-SSC-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Sus scrofa)
REACT:R-SSC-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Sus scrofa)
REACT:R-GGA-5654692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
REACT:R-HSA-9629917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 Q282TER does not translocate to the nucleus (Homo sapiens)
REACT:R-RNO-194518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoA is activated by nucleotide exchange and inhibits axonal growth (Rattus norvegicus)
REACT:R-SPO-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Schizosaccharomyces pombe)
RHEA:64979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 H(+) + 2 phosphate
EC:3.4.21.63	skos:altLabel	"Aspergillus alkaline proteinase"
EC:3.4.21.63	skos:altLabel	"aspergillopeptidase B"
EC:3.4.21.63	skos:prefLabel	"oryzin"
EC:3.4.21.63	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oryzin"
REACT:R-MMU-8949659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Mus musculus)
RHEA:30169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 1,7-bisphosphate => D-erythrose 4-phosphate + dihydroxyacetone phosphate
RHEA:15733	skos:prefLabel	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase"
RHEA:15733	skos:altLabel	"trihydroxycoprostanoyl-CoA oxidase"
RHEA:15733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase"
RHEA:15733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2
RHEA:15733	skos:altLabel	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase"
RHEA:15733	skos:altLabel	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase"
RHEA:15733	skos:altLabel	"THCA-CoA oxidase"
RHEA:15733	skos:altLabel	"THC-CoA oxidase"
REACT:R-HSA-9704248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM4 binds CHRM4 antagonists (Homo sapiens)
RHEA:34002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zymosterol <=> 5alpha-cholesta-7,24-dien-3beta-ol
RHEA:28881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-tryptophan(out) => H(+)(in) + L-tryptophan(in)
REACT:R-SSC-181450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Sus scrofa)
REACT:R-RNO-3322434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP dissociates from ub-TLE (Rattus norvegicus)
RHEA:12241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)
REACT:R-CFA-2328033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds latent TGF-beta (Canis familiaris)
REACT:R-HSA-374909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabolism of Noradrenaline (Homo sapiens)
REACT:R-GGA-5654679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR3 (Gallus gallus)
REACT:R-RNO-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Rattus norvegicus)
RHEA:57303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + H(+) + lactate
RHEA:63854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxydodecanoate => dodecanoate + O2
RHEA:68731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nuclear hormone receptor
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcitriol receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin A receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RXR
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ligand-dependent nuclear receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	retinoid-X receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin D3 receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin D receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	androgen receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ligand-dependent transcription factor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thyroid hormone receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	estrogen nuclear receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ecdysteroid hormone receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1,25-(OH)2D3 receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	9-cis retinoic acid receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	retinoic acid receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glucocorticoid receptor activity
GO:0004879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	juvenile hormone receptor activity
REACT:R-DDI-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Dictyostelium discoideum)
RHEA:56308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56308	skos:prefLabel	"1,2-dehydroreticuline synthase"
RHEA:56308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,2-dehydroreticuline synthase"
RHEA:56308	skos:altLabel	"CYP82Y2"
RHEA:65683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine
RHEA:30703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salicylate decarboxylase"
RHEA:30703	skos:prefLabel	"salicylate decarboxylase"
RHEA:30703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + salicylate = CO2 + phenol
RHEA:30703	skos:altLabel	"salicylic acid decarboxylase"
RHEA:24733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + H(+) <=> aniline + CO2
RHEA:18588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
REACT:R-BTA-452097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruited STAT5 is phosphorylated (Bos taurus)
REACT:R-BTA-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Bos taurus)
REACT:R-DRE-2022403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)
RHEA:38170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + hexadecanoyl-CoA <=> CoA + hexadecanyl hexadecanoate
REACT:R-SSC-74993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Sus scrofa)
RHEA:60010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA with a 3' CC end + 2 diphosphate => a tRNA precursor + 2 CTP
REACT:R-GGA-453104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
RHEA:53036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-CEL-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Caenorhabditis elegans)
GO:0017056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of nuclear pore
GO:0017056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral mRNA Export (Homo sapiens)
GO:0017056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleocytoplasmic transporter activity
GO:0017056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nuclear pore activity
REACT:R-DRE-5622134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRABP1 binds atRA (Danio rerio)
GO:0043995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H4-K5 specific)
GO:0043995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K5 acetyltransferase activity
GO:0043995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H4-K5 specific)
GO:0043995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H4-K5 specific)
GO:0008842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate-purine nucleoside kinase activity
GO:0008842	skos:prefLabel	"diphosphate-purine nucleoside kinase"
GO:0008842	skos:altLabel	"pyrophosphate-dependent nucleoside kinase"
GO:0008842	skos:altLabel	"pyrophosphate-purine nucleoside kinase"
GO:0008842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate-purine nucleoside kinase activity
GO:0008842	skos:altLabel	"diphosphate-dependent nucleoside kinase"
GO:0008842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate-dependent nucleoside kinase activity
GO:0008842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphate-dependent nucleoside kinase activity
GO:0008842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diphosphate-purine nucleoside kinase"
GO:0008842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphate:purine nucleoside phosphotransferase activity
RHEA:57099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + methanethiol
RHEA:70037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol => 6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-8957389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Xenopus tropicalis)
GO:0018464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity
GO:0018464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypimeloyl-CoA dehydrogenase activity
RHEA:70098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-methyl-tetronate + o-quinone methide <=> peniphenone D
RHEA:56301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]
RHEA:50235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Homo sapiens)
RHEA:51533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + urate => 5-hydroxyisourate + H2O + NADP(+)
RHEA:60130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O
REACT:R-MMU-380508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NuMA to the centrosomes (Mus musculus)
REACT:R-BTA-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Bos taurus)
EC:3.4.22.51	skos:altLabel	"cruzain"
EC:3.4.22.51	skos:altLabel	"trypanopain"
EC:3.4.22.51	skos:prefLabel	"cruzipain"
EC:3.4.22.51	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cruzipain"
EC:3.4.22.51	skos:altLabel	"congopain"
EC:3.4.22.51	skos:altLabel	"evansain"
RHEA:70123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-8981657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds PTPRZ1 (Gallus gallus)
REACT:R-BTA-2152276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of transmembrane collagens (Bos taurus)
REACT:R-CFA-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Canis familiaris)
REACT:R-SCE-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Saccharomyces cerevisiae)
RHEA:40497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2
REACT:R-MMU-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)
REACT:R-SPO-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Schizosaccharomyces pombe)
GO:0030614	skos:prefLabel	"With disulfide as acceptor"
GO:0030614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor
GO:0030614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With disulfide as acceptor"
GO:0030614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor
REACT:R-DME-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Drosophila melanogaster)
REACT:R-RNO-6810464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT14 hydrolyses UDP-Glc to G1P and UMP (Rattus norvegicus)
RHEA:58605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 H(+) + NADH + O2 => FADH2-C4alpha-hydroperoxide + NAD(+)
REACT:R-DRE-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)
REACT:R-HSA-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Homo sapiens)
RHEA:40667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate = 2-iminopropanoate
REACT:R-DRE-2161660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGE2 by PTGES (Danio rerio)
REACT:R-CEL-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Caenorhabditis elegans)
RHEA:11027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NH4(+) <=> ADP + 2 H(+) + phosphoramidate
RHEA:41252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate
REACT:R-HSA-964800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuromedin-U receptors bind neuromedins U, S (Homo sapiens)
RHEA:71766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + citrate(in) <=> 2-oxoglutarate(in) + citrate(out)
REACT:R-PFA-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Plasmodium falciparum)
REACT:R-MMU-111289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)
GO:0018598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylsilanetriol oxidase activity
RHEA:21623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NAD(+) <=> FMN + 2 H(+) + NADH
REACT:R-HSA-2730959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN7:OSTM1 exchanges Cl- for H+ (Homo sapiens)
REACT:R-HSA-5602353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective IRAK4 variants do not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)
RHEA:34689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine => AH2 + N-acyl-15-methylhexadecasphinganine + O2
REACT:R-GGA-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Gallus gallus)
RHEA:65233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydodecanoyl-CoA + H2O => 3-hydroxydodecanoate + CoA + H(+)
GO:0033928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannan 1,4-beta-mannobiosidase activity
GO:0033928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,4-beta-mannobiohydrolase activity
GO:0033928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-mannanase activity
GO:0033928	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1,4-beta-D-mannan mannobiohydrolase activity
GO:0033928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannan 1,4-mannobiosidase activity
REACT:R-DRE-5668947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates myosin phosphatase (Danio rerio)
RHEA:24965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitetrol + H2O + 2 oxidized [adrenodoxin]
RHEA:12001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + NADP(+) => CO2 + NADPH
EC:1.14.12.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-halobenzoate 1,2-dioxygenase"
EC:1.14.12.13	skos:altLabel	"2-chlorobenzoate 1,2-dioxygenase"
EC:1.14.12.13	skos:prefLabel	"2-halobenzoate 1,2-dioxygenase"
REACT:R-XTR-9638120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU4 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)
RHEA:63403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(II)-hydroxyheme i <=> Fe(II)-heme a + H2O
RHEA:38084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-HSA-373724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds NCK (Homo sapiens)
REACT:R-CFA-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Canis familiaris)
REACT:R-BTA-9027272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)
REACT:R-BTA-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Bos taurus)
REACT:R-BTA-211191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF with alpha:beta importin (Bos taurus)
RHEA:21566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxoacyl-CoA + CoA => acetyl-CoA + an acyl-CoA
REACT:R-DRE-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Danio rerio)
RHEA:47799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aralkylamine + H2O + 2 oxidized [azurin] <=> an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]
REACT:R-HSA-77342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Homo sapiens)
RHEA:17260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + vinorine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine
REACT:R-SSC-6800298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF dimer binds MET (Sus scrofa)
REACT:R-XTR-1482907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Xenopus tropicalis)
REACT:R-CFA-2064417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-1 (TJP1) (Canis familiaris)
REACT:R-GGA-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Gallus gallus)
RHEA:50382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA => 3 H(+) + 3 malonyl-CoA
REACT:R-PFA-5618085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Plasmodium falciparum)
REACT:R-SSC-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Sus scrofa)
RHEA:50667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-DRE-73718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBF-1 Binds rDNA Promoter (Danio rerio)
REACT:R-BTA-114264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAX to the mitochondria (Bos taurus)
REACT:R-CFA-1602454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proMMP9 binds TIMP1 (Canis familiaris)
RHEA:53285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + scyllo-inosose => 3-dehydro-scyllo-inosose + H(+) + NADH
GO:0008683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pre-2-oxoglutarate decarboxylase activity
GO:0008683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate decarboxylase activity
GO:0008683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)
GO:0008683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate carboxy-lyase activity
GO:0008683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutaric decarboxylase activity
GO:0008683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutarate decarboxylase activity
REACT:R-HSA-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Homo sapiens)
RHEA:22710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + glutathione + H(+) => H2O + S-acylglutathione
GO:0070204	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MenD
GO:0070204	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SEPHCHC synthase activity
GO:0070204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
REACT:R-HSA-420173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR1,CRHR2-1 binds CRH,UCN (Homo sapiens)
REACT:R-GGA-170087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Gallus gallus)
RHEA:17502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + polyneuridine aldehyde => 16-epivellosimine + CO2 + methanol
RHEA:40183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2
REACT:R-BTA-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Bos taurus)
RHEA:22270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + streptomycin 6-phosphate => ATP + streptomycin
REACT:R-RNO-2161745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Rattus norvegicus)
REACT:R-DDI-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Dictyostelium discoideum)
REACT:R-SSC-198315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IRS recruits PI3K to the plasma membrane and activates it (Sus scrofa)
REACT:R-GGA-8857555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates GPNMB (Gallus gallus)
RHEA:32100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + TRIBOA beta-D-glucoside => DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine
RHEA:33060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoamide + NAD(+) => (R)-lipoamide + H(+) + NADH
EC:3.4.21.69	skos:prefLabel	"protein C (activated)"
EC:3.4.21.69	skos:altLabel	"activated blood coagulation factor XIV"
EC:3.4.21.69	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein C (activated)"
EC:3.4.21.69	skos:altLabel	"autoprothrombin IIA"
RHEA:43809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-BTA-8953339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNPH1 hydrolyses dGMP (Bos taurus)
REACT:R-HSA-2562564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 processing within TLR4 complex (Homo sapiens)
GO:1990889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H4K20me3 modified histone binding
GO:0016701	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	oxygenase
GO:0016701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2"
GO:0016701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0016701	skos:prefLabel	"Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2"
GO:0016701	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous
REACT:R-HSA-9032036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 translocates from neutrophil cytosol to platelet cytosol (Homo sapiens)
RHEA:42471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + salicylate
REACT:R-BTA-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)
RHEA:70722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) <=> L-alanine(out)
REACT:R-GGA-9731924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds EDNs (Gallus gallus)
REACT:R-CFA-1067688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Canis familiaris)
RHEA:36342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine
RHEA:18984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantolactone + NADP(+) <=> 2-dehydropantolactone + H(+) + NADPH
RHEA:33289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline + AH2 + propane-1,3-diamine => A + spermidine
REACT:R-SSC-8854908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates RET:GDNF:GFRA dimer (Sus scrofa)
REACT:R-HSA-2395818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)
REACT:R-HSA-6806831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5Rs reduce MetHb to HbA (Homo sapiens)
REACT:R-RNO-5665802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Rattus norvegicus)
REACT:R-HSA-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
RHEA:41583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate <=> 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate
REACT:R-XTR-4085331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-1 SUMOylates PARK7 with SUMO1 (Xenopus tropicalis)
RHEA:42672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-glutamyl hercynylcysteine S-oxide synthase"
RHEA:42672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O
RHEA:42672	skos:prefLabel	"gamma-glutamyl hercynylcysteine S-oxide synthase"
RHEA:10191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + acetyl-CoA + H2O <=> (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
REACT:R-RNO-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Rattus norvegicus)
RHEA:53678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2
REACT:R-DRE-193065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Danio rerio)
RHEA:13842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(II)2-[transferrin] + H(+) + NAD(+) => Fe(III)2-[transferrin] + NADH
REACT:R-DRE-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Danio rerio)
REACT:R-HSA-5654397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS2 (Homo sapiens)
RHEA:23617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-alpha-santonin + NADP(+) => alpha-santonin + H(+) + NADPH
RHEA:65148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phloretin + UDP-alpha-D-glucose = H(+) + trilobatin + UDP
REACT:R-PFA-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Plasmodium falciparum)
REACT:R-GGA-6805546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I binds keratin type II (Gallus gallus)
REACT:R-RNO-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Rattus norvegicus)
REACT:R-XTR-1433542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV1 (Xenopus tropicalis)
REACT:R-HSA-1912369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH precursor cleaved to form mature NOTCH (Homo sapiens)
REACT:R-MMU-1296043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of HCN channels (Mus musculus)
RHEA:33475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)
RHEA:36241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O
RHEA:27532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-XTR-5218643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90AA1 binds p-6Y-VEGFR2 (Xenopus tropicalis)
RHEA:57983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside F1 + H(+) + UDP
RHEA:40094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxyhexacosanoate + NAD(+) <=> 26-oxohexacosanoate + H(+) + NADH
RHEA:22522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + H(+) + H2O2 => all-trans-retinal + H2O + O2
REACT:R-DME-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Drosophila melanogaster)
REACT:R-DRE-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Danio rerio)
REACT:R-GGA-8853800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARTN binds RET:GFRA1,GFRA3 (Gallus gallus)
RHEA:41093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-CEL-9033949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Caenorhabditis elegans)
REACT:R-HSA-9007640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP4 gene expression is inhibited by E2F6 (Homo sapiens)
RHEA:59019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) <=> CO2 + cycloeucalenone + NADH
RHEA:54788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide
RHEA:56346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP => a 7-hydroxyisoflavone + UDP-alpha-D-glucose
REACT:R-HSA-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Homo sapiens)
REACT:R-CEL-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)
RHEA:12249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + UDP-N-acetyl-alpha-D-muramate => H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
REACT:R-HSA-9028505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 recruits PI3K (Homo sapiens)
GO:0050274	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity
GO:0050274	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity
GO:0050274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicyl-alcohol b-D-glucosyltransferase activity
GO:0050274	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity
GO:0050274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicyl-alcohol beta-D-glucosyltransferase activity
GO:0050274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicyl-alcohol glucosyltransferase activity
GO:0050274	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity
REACT:R-HSA-3222128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOC2L binds TP53 (Homo sapiens)
RHEA:15967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-HSA-167136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 5 through 9 on the growing HIV-1 transcript (Homo sapiens)
REACT:R-CFA-75883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHRS7B reduces GO3P to HXDG3P (Canis familiaris)
REACT:R-BTA-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Bos taurus)
REACT:R-BTA-2995376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Bos taurus)
RHEA:24436	skos:altLabel	"methanophenazine hydrogenase"
RHEA:24436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + methanophenazine = dihydromethanophenazine
RHEA:24436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Methanosarcina-phenazine hydrogenase"
RHEA:24436	skos:prefLabel	"Methanosarcina-phenazine hydrogenase"
RHEA:24436	skos:altLabel	"methylviologen-reducing hydrogenase"
RHEA:36558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + sphinganine <=> CoA + H(+) + N-eicosanoylsphinganine
GO:0016427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (cytosine) methyltransferase activity
RHEA:43140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine
RHEA:43140	skos:prefLabel	"tRNA (guanine(26)-N(2))-dimethyltransferase"
RHEA:43140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (guanine(26)-N(2))-dimethyltransferase"
RHEA:43140	skos:altLabel	"tRNA (m(2)2G26)dimethyltransferase"
REACT:R-RNO-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Rattus norvegicus)
RHEA:18323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-leucine
GO:0001733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cerebroside sulfotransferase activity
GO:0001733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity
GO:0001733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycosphingolipid sulfotransferase activity
GO:0001733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolipid sulfotransferase activity
GO:0001733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosylceramide sulfotransferase activity
GO:0001733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GSase
GO:0001733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactolipid sulfotransferase activity
GO:0001733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactocerebroside sulfotransferase activity
GO:0001733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosylceramide sulphotransferase activity
GO:0001733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity
RHEA:37188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-XTR-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Xenopus tropicalis)
RHEA:20968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arabinonate dehydratase"
RHEA:20968	skos:prefLabel	"L-arabinonate dehydratase"
RHEA:20968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O
RHEA:20968	skos:altLabel	"L-arabinonate hydro-lyase"
REACT:R-PFA-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Plasmodium falciparum)
EC:7.1.3.-	skos:prefLabel	"Hydron translocation linked to the hydrolysis of diphosphate"
EC:7.1.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hydron translocation linked to the hydrolysis of diphosphate"
REACT:R-DRE-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Danio rerio)
RHEA:66840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:45495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]
RHEA:57254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + GTP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP
REACT:R-SSC-5226904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Sus scrofa)
REACT:R-HSA-9033276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2 binds TIAM1 (Homo sapiens)
REACT:R-CEL-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Caenorhabditis elegans)
REACT:R-XTR-1013020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Xenopus tropicalis)
RHEA:19731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + CO2 => acetoacetate + H(+)
REACT:R-HSA-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Homo sapiens)
REACT:R-DME-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Drosophila melanogaster)
RHEA:12152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4S,5S,6R)-pentachlorocyclohexene = (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)
RHEA:14340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate
RHEA:22536	skos:prefLabel	"tetrahydrocolumbamine 2-O-methyltransferase"
RHEA:22536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrahydrocolumbamine 2-O-methyltransferase"
RHEA:22536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine
REACT:R-CEL-380869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked dopamine loaded synaptic vesicle (Caenorhabditis elegans)
REACT:R-CEL-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)
RHEA:69725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-CoA + AMP + H(+) => (indol-3-yl)acetyl-AMP + CoA
GO:0050998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric-oxide synthase binding
GO:0050998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOS binding
REACT:R-MMU-167427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid dissociates from MOR (Mus musculus)
REACT:R-CFA-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
RHEA:64582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + nerylneryl diphosphate => (2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate
RHEA:52298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:24236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + trimethylamine = 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide
REACT:R-HSA-77277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Homo sapiens)
REACT:R-CEL-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Caenorhabditis elegans)
REACT:R-GGA-193653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF homodimer binds to p75NTR (Gallus gallus)
RHEA:18862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine => a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Canis familiaris)
REACT:R-XTR-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)
REACT:R-HSA-5686469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
RHEA:64026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine)
RHEA:53692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine
REACT:R-RNO-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Rattus norvegicus)
GO:0050256	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity
GO:0050256	skos:altLabel	"ribitol 5-phosphate dehydrogenase"
GO:0050256	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, ribitol 5-phosphate
GO:0050256	skos:prefLabel	"ribitol-5-phosphate 2-dehydrogenase"
GO:0050256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribitol-5-phosphate 2-dehydrogenase activity
GO:0050256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribitol-5-phosphate 2-dehydrogenase"
REACT:R-BTA-158750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Bos taurus)
REACT:R-CFA-448421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 translocates from the ER lumen to the extracellular region (Canis familiaris)
REACT:R-XTR-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Xenopus tropicalis)
RHEA:66550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate => 3'-phosphoadenylyl sulfate + 4-nitrophenol
REACT:R-XTR-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Xenopus tropicalis)
RHEA:14098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-aspartate => L-phenylalanine + oxaloacetate
RHEA:40856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + undecanoyl-CoA => FADH2 + trans-2-undecenoyl-CoA
REACT:R-RNO-1678998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosomal TLRs pass through the Golgi (Rattus norvegicus)
GO:0062186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anandamide epoxidase activity
GO:0062186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonoylethanolamide epoxidase activity
REACT:R-HSA-163069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol (Homo sapiens)
REACT:R-DME-4570489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO2 (Drosophila melanogaster)
EC:3.1.1.3	skos:altLabel	"lipase"
EC:3.1.1.3	skos:altLabel	"tributyrase"
EC:3.1.1.3	skos:prefLabel	"triacylglycerol lipase"
EC:3.1.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"triacylglycerol lipase"
EC:3.1.1.3	skos:altLabel	"triglyceride lipase"
RHEA:20083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoate + methylamine => H2O + N-methylhexanamide
REACT:R-RNO-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Rattus norvegicus)
REACT:R-XTR-1475032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Xenopus tropicalis)
RHEA:63750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP + zolarsartan-2-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan
RHEA:63643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+) <=> 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-BTA-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Bos taurus)
REACT:R-HSA-1222755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxynitrite is reduced to nitrite by Tpx (Homo sapiens)
REACT:R-GGA-5635102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 is internalized (Gallus gallus)
GO:0005006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGF-alpha receptor activity
GO:0005006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epidermal growth factor-activated receptor activity
GO:0005006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR
GO:0005006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epidermal growth factor receptor activity
GO:0005006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor-alpha receptor activity
GO:0005006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF receptor activity
REACT:R-HSA-9024630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5 (Homo sapiens)
RHEA:26443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + ethanol => a ubiquinol + acetaldehyde
REACT:R-HSA-5621366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to p-Y65,Y76-FCER1G (Homo sapiens)
RHEA:37386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-DDI-176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST trimers transfer GS from GSH to luminal substrates (Dictyostelium discoideum)
RHEA:11098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate
REACT:R-DRE-9656893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1MW binds 11cRAL (Danio rerio)
REACT:R-HSA-9009452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 gene expression is stimulated by RUNX2 (Homo sapiens)
REACT:R-DRE-158399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein binds SERPING1 (Danio rerio)
RHEA:72147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + S-adenosyl-L-methionine + UTP = 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine
RHEA:33441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H(+) + H2O2 => glyoxal + H2O + O2
REACT:R-SSC-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Sus scrofa)
REACT:R-BTA-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Bos taurus)
RHEA:62064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose 6-phosphate + NAD(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH
REACT:R-RNO-5665999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 translocates from cytosol to the nucleus (Rattus norvegicus)
RHEA:21631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + NADPH + O2 <=> acetate + androst-4-ene-3,17-dione + H2O + NADP(+)
REACT:R-CFA-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
RHEA:48718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-oxo-(9Z,11E)-octadecadienoate + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-RNO-76456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-atom dealkylation of dextromethorphan (Rattus norvegicus)
REACT:R-GGA-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Gallus gallus)
REACT:R-DME-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Drosophila melanogaster)
REACT:R-XTR-5635839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3:SUFU dissociates (Xenopus tropicalis)
REACT:R-SSC-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Sus scrofa)
RHEA:23897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucuronate => 3-deoxy-D-glycero-2,5-hexodiulosonate
REACT:R-BTA-9008696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) translocates from the cytosol to the nucleus (Bos taurus)
REACT:R-HSA-9615042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral 2',5'-PDE cleaves 2'-5' oligoadenylates  (Homo sapiens)
REACT:R-HSA-351963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A18 transports Gly from extracellular region to cytosol (Homo sapiens)
EC:1.2.1.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinate-semialdehyde dehydrogenase [NAD(P)(+)]"
EC:1.2.1.16	skos:prefLabel	"succinate-semialdehyde dehydrogenase [NAD(P)(+)]"
REACT:R-MMU-6797913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARDH:FAD oxidatively demethylates SARC to Gly (Mus musculus)
REACT:R-MMU-186778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 binds to the active receptor (Mus musculus)
REACT:R-RNO-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-HSA-975106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
REACT:R-HSA-9604264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAM10 cleaves NOTCH4 (Homo sapiens)
RHEA:60888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)
RHEA:45543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-CFA-2395302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysino-5-ketonorleucine cross-links (Canis familiaris)
REACT:R-HSA-3149519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC decyanates CNCbl (Homo sapiens)
REACT:R-SSC-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Sus scrofa)
REACT:R-BTA-194518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoA is activated by nucleotide exchange and inhibits axonal growth (Bos taurus)
RHEA:44152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-phosphate + H2O = myo-inositol + phosphate
REACT:R-BTA-193694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 is recruited and forms a complex with TRAF6 (Bos taurus)
RHEA:51858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out)
RHEA:39942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
RHEA:15000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxylimonoate + H2O <=> deoxylimononate D-ring-lactone + H(+)
REACT:R-HSA-111966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 binds CALM1:4Ca2+ (Homo sapiens)
REACT:R-HSA-9654752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF4 binds the PPP1R15A (GADD34) promoter (Homo sapiens)
RHEA:44980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + butanoyl-CoA = CoA + O-butanoyl-(R)-carnitine
REACT:R-DRE-5624126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome bind ciliary cargo (Danio rerio)
RHEA:64616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferol + acetyl-CoA = (E)-coniferyl acetate + CoA
REACT:R-XTR-2161195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Xenopus tropicalis)
RHEA:11427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[myosin heavy-chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]
REACT:R-HSA-4641249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Homo sapiens)
REACT:R-RNO-111289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)
RHEA:13671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpyridine-5-carboxylate + CO2 => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+)
RHEA:67056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chermesin D + S-adenosyl-L-methionine = chermesin D methyl ester + S-adenosyl-L-homocysteine
GO:0140927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-di-GMP transmembrane transporter activity
RHEA:18382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone + phosphoenolpyruvate => dihydroxyacetone phosphate + pyruvate
RHEA:14542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + H2O => cholate + CoA + H(+)
GO:0045435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lycopene epsilon cyclase activity
GO:0045435	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lycopene cyclase
REACT:R-DME-1638104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Drosophila melanogaster)
REACT:R-SSC-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)
REACT:R-MMU-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Mus musculus)
REACT:R-DRE-6805755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 dimethylates TP53 (Danio rerio)
RHEA:70953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + H2O2 + NH4(+) => D-serine + H2O + O2
REACT:R-CFA-349444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of COP1 at Ser-387  by ATM (Canis familiaris)
RHEA:49039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-pluviatolide + S-adenosyl-L-methionine <=> (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-606289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	New CENPA-containing nucleosomes are deposited at the centromere (Canis familiaris)
REACT:R-RNO-9645535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 phosphorylates TIFA (Rattus norvegicus)
REACT:R-SPO-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Schizosaccharomyces pombe)
REACT:R-SSC-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Sus scrofa)
RHEA:55608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base
REACT:R-MMU-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Mus musculus)
GO:0071553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled pyrimidinergic nucleotide receptor activity
GO:0071553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidinergic nucleotide receptor activity, G-protein coupled
GO:0071553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidinergic nucleotide receptor activity, G protein coupled
GO:0071553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled pyrimidinergic nucleotide receptor activity
GO:0071553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled pyrimidinergic nucleotide receptor activity
RHEA:25536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate = diphosphate + ent-sandaracopimara-8(14),15-diene
RHEA:25536	skos:prefLabel	"ent-sandaracopimaradiene synthase"
RHEA:25536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-sandaracopimaradiene synthase"
RHEA:25536	skos:altLabel	"ent-sandaracopimara-8(14),15-diene synthase"
GO:0015425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonpolar-amino acid-transporting ATPase activity
GO:0015425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonpolar-amino acid ABC transporter
GO:0015425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonpolar amino acid-transporting ATPase activity
GO:0015425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent nonpolar-amino acid transporter activity
GO:0015425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled nonpolar-amino acid transporter activity
GO:0015425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonpolar-amino-acid-transporting ATPase activity
GO:0015425	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine/isoleucine/valine porter activity
RHEA:14724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-xylose + zeatin <=> H(+) + O-beta-D-xylosylzeatin + UDP
RHEA:58128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:70249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP => N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose
REACT:R-RNO-8875183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates activated MET (Rattus norvegicus)
RHEA:12481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate + pyruvate => 4,5-dioxopentanoate + L-alanine
RHEA:31339	skos:altLabel	"[acyl-carrier protein]:acetate ligase"
RHEA:31339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetate--[acyl-carrier protein] ligase"
RHEA:31339	skos:prefLabel	"acetate--[acyl-carrier protein] ligase"
RHEA:31339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + holo-[ACP] = acetyl-[ACP] + AMP + diphosphate
RHEA:31339	skos:altLabel	"ACP-SH:acetate ligase"
RHEA:14802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP
RHEA:39727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin(in) = a sphingomyelin(out)
REACT:R-SSC-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Sus scrofa)
RHEA:49503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)
RHEA:11425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[myosin heavy-chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]
REACT:R-CEL-9649963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC3 channel blockers bind ASIC3 trimer (Caenorhabditis elegans)
RHEA:54991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 e(-) + 4 H(+)(in) + O2(in) <=> 2 H2O(in)
RHEA:48501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoylglycerol => glycerol + H(+) + octanoate
RHEA:62450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + L-glutamyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP
REACT:R-DME-2046175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further sulfation on galactose residues produces KSPG (Drosophila melanogaster)
REACT:R-RNO-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Rattus norvegicus)
RHEA:17388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypotaurine + NAD(+) <=> H(+) + NADH + taurine
RHEA:60407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-HSA-1655826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
REACT:R-BTA-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Bos taurus)
REACT:R-XTR-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)
GO:0047864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	microsomal oxidase II
GO:0047864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	microsomal N-oxide dealkylase activity
GO:0047864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)
GO:0047864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethylaniline-N-oxide formaldehyde-lyase activity
GO:0047864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylaniline-N-oxide aldolase activity
RHEA:69760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + nonanal => 2 H(+) + NADH + nonanoate
RHEA:63593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:29185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + menaquinone-8 + 2 superoxide => menaquinol-8 + 2 O2
REACT:R-CFA-183126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to surface-associated C3b (Canis familiaris)
REACT:R-CFA-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Canis familiaris)
RHEA:55188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyluridine(54) in tRNA + ATP + hydrogen sulfide = 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate
REACT:R-CEL-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Caenorhabditis elegans)
REACT:R-MMU-937337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Mus musculus)
REACT:R-MMU-5689317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the pre-incision complex in GG-NER (Mus musculus)
RHEA:56028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
REACT:R-CFA-9014434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)
REACT:R-CFA-873924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IFNGR1 by JAK kinases (Canis familiaris)
REACT:R-SSC-177924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Gab1 by SHP2 (Sus scrofa)
RHEA:31430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (1S,5S,6R)-alpha-bergamotene + diphosphate
RHEA:49738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + deoxyviolacein + 2 H2O + NAD(+) => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate
RHEA:19770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phaseollidin hydrate => H2O + phaseollidin
RHEA:68291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptanoyl-CoA + L-seryl-[protein] <=> CoA + O-heptanoyl-L-seryl-[protein]
REACT:R-DDI-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Dictyostelium discoideum)
REACT:R-CEL-390886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH4 binds Hist (Caenorhabditis elegans)
RHEA:41272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)
RHEA:11112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isochorismate = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate
RHEA:11112	skos:altLabel	"2,3-dihydro-2,3-dihydroxybenzoate synthase"
RHEA:11112	skos:prefLabel	"isochorismatase"
RHEA:11112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isochorismatase"
GO:0047032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-alpha-hydroxyglycyrrhetinate dehydrogenase activity
GO:0047032	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha-hydroxyglycyrrhetinate dehydrogenase activity
GO:0047032	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity
REACT:R-CFA-114392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Canis familiaris)
REACT:R-RNO-6807064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces ZYMOL to ZYMSTNL (Rattus norvegicus)
RHEA:66521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:49911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)
REACT:R-PFA-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Plasmodium falciparum)
RHEA:57540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NTP-ribonucleotide-RNA + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)
RHEA:57335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 3 O2 + 3 propionate 3-nitronate <=> 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite
RHEA:71589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + 2-oxoglutarate(in) => (S)-malate(in) + 2-oxoglutarate(out)
RHEA:13003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O
GO:2001081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1,4)-beta-D-galactan binding
GO:2001081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1->4)-beta-D-galactan binding
REACT:R-DRE-2752115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds CD44 (Danio rerio)
REACT:R-BTA-76373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxylation of 4-aminobiphenyl (Bos taurus)
RHEA:43913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-173709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C7 binds C5b:C6 (Danio rerio)
REACT:R-DRE-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Danio rerio)
RHEA:56264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
GO:0035252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-xylosyltransferase activity
RHEA:27368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + S-adenosyl-L-methionine <=> bromomethane + S-adenosyl-L-homocysteine
REACT:R-HSA-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Homo sapiens)
REACT:R-XTR-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Xenopus tropicalis)
RHEA:19237	skos:altLabel	"4-methyl-3-enelactone methyl isomerase"
RHEA:19237	skos:altLabel	"4-methyl-2-enelactone methyl-isomerase"
RHEA:19237	skos:prefLabel	"4-carboxymethyl-4-methylbutenolide mutase"
RHEA:19237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-carboxymethyl-4-methylbutenolide mutase"
RHEA:19237	skos:altLabel	"4-methylmuconolactone methylisomerase"
RHEA:19237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide
REACT:R-BTA-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Bos taurus)
REACT:R-HSA-174786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Homo sapiens)
RHEA:68883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + salicylate <=> AMP + diphosphate + NADP(+) + salicylaldehyde
RHEA:43982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2
RHEA:39207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexacosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexacosanoyl-CoA + NADP(+)
RHEA:47181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) => (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH
REACT:R-SCE-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Saccharomyces cerevisiae)
RHEA:69217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) => (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH
RHEA:36132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + S-adenosyl-L-methionine => methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine
REACT:R-RNO-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Rattus norvegicus)
RHEA:14308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-proline + tRNA(Pro) <=> AMP + diphosphate + L-prolyl-tRNA(Pro)
REACT:R-CFA-3222093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 binds TP53 and EP300 (Canis familiaris)
GO:0008134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription factor binding
GO:0008134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TF binding
GO:0008134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription regulator binding
RHEA:20938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + H2O => 2,3-dihydroxy-3-methylbutanoate
RHEA:70158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chermesin D methyl ester = A + asnovolin J
REACT:R-RNO-210881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Tie2/Ang1 complex (Rattus norvegicus)
RHEA:68214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol
REACT:R-CFA-1297444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of cAMP to HCN channels (Canis familiaris)
RHEA:39240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-triacontenoyl-CoA + H(+) + NADPH => NADP(+) + triacontanoyl-CoA
RHEA:67850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA
REACT:R-MMU-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Mus musculus)
REACT:R-MMU-202478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction and oligomerization of MALT1 to Bcl10 (Mus musculus)
REACT:R-SSC-5676599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF trimer binds BAFFR (Sus scrofa)
REACT:R-SSC-191983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol is hydroxylated to 25-hydroxycholesterol (Sus scrofa)
REACT:R-HSA-9687455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSV1 RIR1 binds RIPK3 (Homo sapiens)
REACT:R-SSC-983424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of COPII coated vesicle (Sus scrofa)
REACT:R-BTA-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Bos taurus)
RHEA:45320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine = H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine
REACT:R-CFA-1655831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 translocates to the nucleus (Canis familiaris)
REACT:R-RNO-1472121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)
REACT:R-DDI-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Dictyostelium discoideum)
RHEA:20724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O
REACT:R-CEL-5688786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds RAD23 (Caenorhabditis elegans)
REACT:R-MMU-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Mus musculus)
REACT:R-RNO-994137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Rattus norvegicus)
REACT:R-HSA-6789114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroxyl radical reacts with the base and sugar moiety of DNA (Homo sapiens)
RHEA:23899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucuronate <=> 3-deoxy-D-glycero-2,5-hexodiulosonate
REACT:R-RNO-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Rattus norvegicus)
RHEA:65251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 5 H(+) + 5 malonyl-CoA <=> 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O
REACT:R-XTR-1605724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Xenopus tropicalis)
GO:0086082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesive protein binding involved in AV node cell-bundle of His cell communication
GO:0086082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesive protein binding involved in atrioventricular node cell-bundle of His cell communication
REACT:R-MMU-449115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)
REACT:R-SSC-3000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PLK1 (Sus scrofa)
RHEA:36552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol => 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)
REACT:R-MMU-159194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)
RHEA:46661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + progesterone => 5beta-pregnan-3,20-dione + NADP(+)
REACT:R-BTA-8848316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36 binds IL1RL2 (Bos taurus)
RHEA:10908	skos:altLabel	"bile acid sulfotransferase I"
RHEA:10908	skos:altLabel	"glycolithocholate sulfotransferase"
RHEA:10908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate
RHEA:10908	skos:altLabel	"bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase"
RHEA:10908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bile-salt sulfotransferase"
RHEA:10908	skos:altLabel	"BAST I"
RHEA:10908	skos:altLabel	"bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase"
RHEA:10908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate
RHEA:10908	skos:prefLabel	"bile-salt sulfotransferase"
REACT:R-SSC-374337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apelin receptor binds to apelin (Sus scrofa)
REACT:R-BTA-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Bos taurus)
RHEA:66222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-omegaDeltaC7-CoA + H2O2 => asc-omegaC7-CoA + O2
REACT:R-BTA-9038161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Bos taurus)
REACT:R-HSA-9762345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDN:ALB dissociates (Homo sapiens)
REACT:R-CEL-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Caenorhabditis elegans)
REACT:R-GGA-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Gallus gallus)
RHEA:52384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-(2-amino-2-carboxyethyl)-L-glutamate synthase"
RHEA:52384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + O-phospho-L-serine = H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate
RHEA:52384	skos:altLabel	"ACEGA synthase"
RHEA:52384	skos:prefLabel	"N-(2-amino-2-carboxyethyl)-L-glutamate synthase"
REACT:R-RNO-1977958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with ERBB3 (Rattus norvegicus)
REACT:R-XTR-9008696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) translocates from the cytosol to the nucleus (Xenopus tropicalis)
RHEA:43439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen III + 3 O2 <=> coproporphyrin III + 3 H2O2
RHEA:21843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
REACT:R-RNO-9013110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC binds effectors at the plasma membrane (Rattus norvegicus)
REACT:R-SPO-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Schizosaccharomyces pombe)
REACT:R-HSA-75010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser 216 by Chk1 (Homo sapiens)
RHEA:13787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + itaconyl-CoA => (3S)-citramalyl-CoA
RHEA:37432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine
RHEA:21678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lavandulyl diphosphate + diphosphate => 2 dimethylallyl diphosphate
RHEA:14355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-xylulose 5-phosphate => 3-dehydro-L-gulonate 6-phosphate + H(+)
RHEA:67754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)
RHEA:54110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + guaia-4,6-diene => (2E,6E)-farnesyl diphosphate
REACT:R-DRE-9624778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD 12mer translocates from ER membrane to extracellular region (Danio rerio)
RHEA:37223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA
EC:3.4.21.22	skos:altLabel	"Christmas factor"
EC:3.4.21.22	skos:prefLabel	"coagulation factor IXa"
EC:3.4.21.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coagulation factor IXa"
REACT:R-XTR-9021520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds WWP2 (Xenopus tropicalis)
GO:0031625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin ligase binding
GO:0031625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin protein ligase binding
RHEA:26501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP
RHEA:30889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydropteroate + H2O => 4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin
REACT:R-CEL-193508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)
REACT:R-RNO-5251955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Rattus norvegicus)
REACT:R-RNO-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Rattus norvegicus)
REACT:R-MMU-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Mus musculus)
GO:0110130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribitol-5-phosphatase activity
GO:0110130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 5-phosphate + H2O = phosphate + ribitol
RHEA:51670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone => 2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:13147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine => 4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate
GO:0036469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-tryptophan decarboxylase"
GO:0036469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan decarboxylase activity
GO:0036469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-tryptophan = CO2 + tryptamine
GO:0036469	skos:prefLabel	"L-tryptophan decarboxylase"
REACT:R-HSA-9684275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3-4 is glycosylated (Homo sapiens)
REACT:R-CFA-392530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S400-Cot phosphorylates NIK (Canis familiaris)
RHEA:33112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => beta-copaene + diphosphate
RHEA:37506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-MMU-5649802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Mus musculus)
RHEA:39212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexacosanoyl-CoA => (2E)-hexacosenoyl-CoA + H2O
REACT:R-MMU-1981157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of collagen propeptide hydroxylysines (Mus musculus)
RHEA:69399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]
REACT:R-CEL-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)
RHEA:63583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxyecdysone 22-phosphate + H2O <=> 20-hydroxyecdysone + phosphate
RHEA:29611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nitrous oxide = H(+) + NADPH + 2 nitric oxide
REACT:R-MMU-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Mus musculus)
REACT:R-MMU-444654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled bile acid receptor binds lithocholic acid (Mus musculus)
RHEA:13186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 4 porphobilinogen => hydroxymethylbilane + 4 NH4(+)
REACT:R-BTA-445813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Smooth Muscle Myosin Light Chains (Bos taurus)
REACT:R-DME-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Drosophila melanogaster)
RHEA:55563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxyeicosatetraenoate <=> a hydroxy-epoxy-eicosatetraenoate
RHEA:54041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => (3E,7E)-dolathalia-3,7,11-triene + diphosphate
RHEA:39672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O
REACT:R-HSA-9634433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid (Homo sapiens)
RHEA:63057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine => 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine
GO:0140211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folic acid:proton symporter activity
REACT:R-RNO-2395257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-hydroxylysino-norleucine cross-links (Rattus norvegicus)
RHEA:61586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine
REACT:R-CFA-5625848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)
REACT:R-DME-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Drosophila melanogaster)
REACT:R-XTR-140736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Xenopus tropicalis)
GO:0034338	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	propionyl esterase activity
GO:0034338	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	short-chain esterase activity
GO:0034338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	short-chain carboxylesterase activity
GO:0034338	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	butyrate esterase activity
GO:0034338	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	butyryl esterase activity
GO:0034338	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methylbutyrate esterase activity
GO:0034338	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methylbutyrase activity
GO:0034338	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	monobutyrase activity
REACT:R-DRE-8985914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Danio rerio)
REACT:R-SSC-158399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein binds SERPING1 (Sus scrofa)
REACT:R-RNO-375160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 binds to ATP (Rattus norvegicus)
RHEA:55903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + L-tryptophan + O2 <=> 6-chloro-L-tryptophan + FAD + 2 H2O
REACT:R-BTA-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Bos taurus)
REACT:R-MMU-69600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
REACT:R-PFA-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Plasmodium falciparum)
REACT:R-SCE-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Saccharomyces cerevisiae)
REACT:R-SPO-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Schizosaccharomyces pombe)
GO:0050308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sugar-phosphate phosphatase activity
GO:0050308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sugar-phosphatase activity
GO:0050308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sugar-phosphate phosphohydrolase activity
REACT:R-MMU-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Mus musculus)
RHEA:53959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-[BtrI ACP] + H(+) <=> 4-aminobutanoyl-[BtrI ACP] + CO2
REACT:R-DRE-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Danio rerio)
GO:0047378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity
GO:0047378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylacetylglycerol acetylhydrolase activity
GO:0047378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylalkylglycerol acetylhydrolase activity
RHEA:40453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O
REACT:R-GGA-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Gallus gallus)
REACT:R-XTR-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Xenopus tropicalis)
REACT:R-CEL-8876472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 binds CHOL (Caenorhabditis elegans)
REACT:R-HSA-5682794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM22 and ADAM23 (Homo sapiens)
REACT:R-DME-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Drosophila melanogaster)
REACT:R-BTA-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Bos taurus)
REACT:R-CFA-749456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
REACT:R-HSA-8937728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX1 (Homo sapiens)
REACT:R-SSC-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Sus scrofa)
REACT:R-DRE-183084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Danio rerio)
GO:0052642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Homo sapiens)
GO:0052642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophosphatidic acid phosphatase activity
GO:0052642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA phosphatase activity
GO:0052642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophosphatidate phosphatase activity
GO:0036191	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)
GO:0036191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indolin-2-one monooxygenase activity
REACT:R-DRE-8853444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PHLDA1 (Danio rerio)
REACT:R-GGA-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Gallus gallus)
REACT:R-HSA-6811431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
RHEA:61521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dopamine => 3-tyramine + A + H2O
REACT:R-DME-1482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by HADH (IM) (Drosophila melanogaster)
REACT:R-RNO-879914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3 stimulation induces Vav binding to Tec kinase (Rattus norvegicus)
RHEA:32654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin D + S-adenosyl-L-methionine <=> erythromycin B + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-193669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to p75NTR:NRIF (Bos taurus)
RHEA:35291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-methyldodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxoisopentadecanoyl-CoA + CO2 + CoA
RHEA:40499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine
RHEA:24024	skos:prefLabel	"5-hydroxydodecatetraenal 1-aminotransferase"
RHEA:24024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
RHEA:24024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-hydroxydodecatetraenal 1-aminotransferase"
RHEA:61458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+) => 7-chlorotetracycline + H(+) + NADPH + O2
RHEA:17339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+) => catechol + O2
RHEA:14833	skos:altLabel	"beta-hydroxy-beta-methylglutaryl coenzyme A reductase"
RHEA:14833	skos:altLabel	"hydroxymethylglutaryl coenzyme A reductase"
RHEA:14833	skos:altLabel	"beta-hydroxy-beta-methylglutaryl CoA-reductase"
RHEA:14833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxymethylglutaryl-CoA reductase"
RHEA:14833	skos:altLabel	"3-hydroxy-3-methylglutaryl coenzyme A reductase"
RHEA:14833	skos:altLabel	"HMG-CoA reductase"
RHEA:14833	skos:prefLabel	"hydroxymethylglutaryl-CoA reductase"
RHEA:14833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH
REACT:R-CFA-114552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate G12/13 (Canis familiaris)
RHEA:52347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:54942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP] => (3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP]
GO:0005025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I transforming growth factor beta receptor activity
GO:0005025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta ligand binding to type I receptor
GO:0005025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I TGF-beta receptor activity
GO:0005025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I TGFbeta receptor activity
GO:0005025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor beta receptor activity, type I
RHEA:13666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP => 3',5'-cyclic GMP + diphosphate
REACT:R-HSA-9008839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAX gene expression is stimulated by RUNX2 (Homo sapiens)
RHEA:47882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octanoate + octanoylglycerol => dioctanoylglycerol + H2O
REACT:R-GGA-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Gallus gallus)
REACT:R-RNO-349593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with Fibronectin (Rattus norvegicus)
RHEA:20665	skos:altLabel	"AF reductase"
RHEA:20665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH
RHEA:20665	skos:prefLabel	"1,5-anhydro-D-fructose reductase"
RHEA:20665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,5-anhydro-D-fructose reductase"
RHEA:28144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	streptothricin D acid => H2O + streptothricin D
GO:0052713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol phosphorylceramide phospholipase activity
RHEA:36690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-hexadecanoylsphing-4-enine
RHEA:10940	skos:prefLabel	"(R)-limonene synthase"
RHEA:10940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-limonene synthase"
RHEA:10940	skos:altLabel	"(+)-limonene synthase"
RHEA:10940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (4R)-limonene + diphosphate
RHEA:72432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + ATP + H(+) => (E)-caffeoyl-AMP + diphosphate
REACT:R-DRE-168405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD oligomer recruites RIP2 (RICK) (Danio rerio)
REACT:R-GGA-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Gallus gallus)
RHEA:54716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:38463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
REACT:R-XTR-391941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLT receptors can bind LTB4 (Xenopus tropicalis)
RHEA:44670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol
REACT:R-CFA-5609665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
RHEA:69609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin] => acetyl-CoA + N-terminal L-methionyl-[tubulin]
REACT:R-DRE-5676589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANKL,sRANKL trimer binds RANK (Danio rerio)
RHEA:62141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + GTP => dTDP + GDP
REACT:R-BTA-9032751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Bos taurus)
REACT:R-DME-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Drosophila melanogaster)
REACT:R-SPO-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Schizosaccharomyces pombe)
REACT:R-SSC-202472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TRAF6 to CBM complex (Sus scrofa)
RHEA:64277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrysophanol-9-anthrone + O2 => chrysophanol + H2O
RHEA:24307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) <=> (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2
GO:0000341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA trimethylguanosine cap binding
GO:0000341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA m2,2,7G cap binding
RHEA:11611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA
REACT:R-BTA-2022851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfer GlcNAc to the heparan chain (Bos taurus)
REACT:R-HSA-5685838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex binds D-loop structures (Homo sapiens)
REACT:R-SSC-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Sus scrofa)
REACT:R-HSA-71050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of the FASL:FAS receptor complex (Homo sapiens)
REACT:R-SSC-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)
RHEA:28158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
REACT:R-DRE-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Danio rerio)
REACT:R-XTR-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Xenopus tropicalis)
RHEA:48774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-vinylbacteriochlorophyllide a + H2O => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a
REACT:R-SSC-8936214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCY2C trimer binds GUCA2A,B (Sus scrofa)
RHEA:31360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + nitrilotriacetate + O2 => ammoniodiacetate + FMN + glyoxylate + H2O
REACT:R-DME-2076508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS2ST1 sulfates IdoA at C2 in heparan sulfate (Drosophila melanogaster)
REACT:R-BTA-352174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Bos taurus)
RHEA:61174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose
REACT:R-DME-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Drosophila melanogaster)
RHEA:12325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => L-asparagine + N-acetyl-D-glucosamine
RHEA:71421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out) => 3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in)
REACT:R-BTA-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Bos taurus)
REACT:R-DME-2395879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)
REACT:R-DRE-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Danio rerio)
REACT:R-MMU-9014627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDS dimers:PXLP dehydrate L-Thr to 2AA (Mus musculus)
REACT:R-GGA-8932275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Gallus gallus)
REACT:R-HSA-8938829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Homo sapiens)
RHEA:50511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]
REACT:R-CFA-375330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 45/Connexin 36 mediated neuronal gap junction communication (Canis familiaris)
RHEA:57049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]
REACT:R-MMU-879909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of STAT5a/b by JAK2 (Mus musculus)
REACT:R-HSA-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)
REACT:R-GGA-5683986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APBB1 and MAPK8 bind diphosphorylated H2AFX (Gallus gallus)
RHEA:23542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-glutamyl-tRNA(Glu) => ATP + L-glutamate + tRNA(Glu)
RHEA:62565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + A + H2O => (4S)-perillyl alcohol + AH2
RHEA:17647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]
RHEA:28473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine(in) <=> pyridoxine(out)
REACT:R-CEL-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-HSA-174446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap from the C-strand (Homo sapiens)
REACT:R-DRE-6809680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTM1 (Danio rerio)
REACT:R-DDI-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Dictyostelium discoideum)
REACT:R-HSA-9637651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esxA translocates from Mtb cytosol to the host's ER (Homo sapiens)
REACT:R-HSA-5651723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)
REACT:R-HSA-2430533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates MASTL (Homo sapiens)
RHEA:12041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(imidazol-5-yl)lactate + NADP(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADPH
RHEA:40904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine
REACT:R-CFA-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Canis familiaris)
RHEA:55632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)
REACT:R-MMU-1889981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Mus musculus)
REACT:R-BTA-2395768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPL hydrolyses TGs from mature CMs (Bos taurus)
REACT:R-CFA-173545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Canis familiaris)
GO:0004801	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycerone transferase activity
GO:0004801	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dihydroxyacetonetransferase activity
GO:0004801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transaldolase activity
GO:0004801	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dihydroxyacetone transferase activity
GO:0004801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
REACT:R-DME-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Drosophila melanogaster)
RHEA:52427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP
REACT:R-CFA-6786095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)
REACT:R-DME-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Drosophila melanogaster)
REACT:R-CFA-4827382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Canis familiaris)
REACT:R-CEL-417820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 receptor can bind to LPA (Caenorhabditis elegans)
REACT:R-CFA-8952044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)
RHEA:19783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3,5-diiodo-L-tyrosine
RHEA:64258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-dodecanoylglycine => dodecanoyl-CoA + glycine
RHEA:35247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate
RHEA:31997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-epi-sesquithujene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:41600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-MMU-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Mus musculus)
REACT:R-RNO-9603983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeX to form LeY (Rattus norvegicus)
REACT:R-BTA-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Bos taurus)
EC:2.5.1.44	skos:prefLabel	"homospermidine synthase"
EC:2.5.1.44	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homospermidine synthase"
RHEA:46442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate:NADP reductase activity
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	triosephosphate dehydrogenase activity
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde 3-phosphate dehydrogenase (NADP)
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate dehydrogenase (NADP)
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glyceraldehyde phosphate dehydrogenase (NADP)
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP-glyceraldehyde-3-phosphate dehydrogenase activity
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)
GO:0008886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP-glyceraldehyde phosphate dehydrogenase
GO:0003857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-keto-reductase activity
GO:0003857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-hydroxyacyl coenzyme A dehydrogenase activity
GO:0003857	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-hydroxybutyrylcoenzyme A dehydrogenase activity
GO:0003857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyacylcoenzyme A dehydrogenase activity
GO:0003857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyacyl-coenzyme A synthetase activity
GO:0003857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyacyl-CoA dehydrogenase activity
GO:0003857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-hydroxyacyl CoA dehydrogenase activity
GO:0003857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyacyl dehydrogenase activity
GO:0003857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoacyl-thioester reductase activity
GO:0003857	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-ketoacyl-CoA reductase
RHEA:49750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 H2O + NADP(+) + proviolacein => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate
REACT:R-BTA-211224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with DFF45 (Bos taurus)
REACT:R-GGA-381262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPARG:RXRA heterodimer (ARF6 complex) (Gallus gallus)
REACT:R-CFA-1592371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP3 (Canis familiaris)
REACT:R-XTR-2473584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP15 (Xenopus tropicalis)
RHEA:32990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol
RHEA:17483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)alamin + NADH => 2 cob(I)alamin + H(+) + NAD(+)
RHEA:16345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate
RHEA:16345	skos:prefLabel	"dolabella-3,7-dien-18-ol synthase"
RHEA:16345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolabella-3,7-dien-18-ol synthase"
REACT:R-RNO-8961021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD binds with itself to form SFTPD 12mer (Rattus norvegicus)
REACT:R-RNO-422021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Rattus norvegicus)
RHEA:39568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:34692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactoyl-CoA => acryloyl-CoA + H2O
RHEA:54706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
REACT:R-CFA-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Canis familiaris)
REACT:R-HSA-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Homo sapiens)
REACT:R-CEL-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Caenorhabditis elegans)
RHEA:20683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-beta-D-glucosyl-cis-zeatin + UDP => cis-zeatin + UDP-alpha-D-glucose
RHEA:57556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1
REACT:R-GGA-201595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plakophilin-1 (Gallus gallus)
RHEA:19296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacylglycerol + ATP <=> ADP + H(+) + monoacyl-sn-glycero-3-phosphate
REACT:R-RNO-186826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to the active receptor (Rattus norvegicus)
RHEA:57807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-3-nitrobenzene + NADH + O2 <=> 4-chlorocatechol + NAD(+) + nitrite
RHEA:19388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vomilenine <=> H(+) + raucaffricine + UDP
GO:0070906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(out) + L-aspartate(in) = L-alanine(in) + L-aspartate(out)
GO:0070906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-alanine antiporter activity
GO:0070906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate/alanine antiporter activity
GO:0070906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate:alanine antiporter activity
RHEA:50354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase] => 3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH
RHEA:67472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + succinyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine
RHEA:70763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-2046175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further sulfation on galactose residues produces KSPG (Danio rerio)
RHEA:22347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA <=> (R)-rosmarinate + CoA
REACT:R-MMU-508247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
REACT:R-DME-917888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF binds 2Fe3+ to form holoTF (Drosophila melanogaster)
REACT:R-HSA-8963734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Homo sapiens)
REACT:R-MMU-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Mus musculus)
RHEA:52134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O
RHEA:16951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + scyllo-inosose => myo-inositol + NAD(+)
RHEA:36415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diphthine synthase"
RHEA:36415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine
RHEA:36415	skos:prefLabel	"diphthine synthase"
RHEA:58803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP + H2O <=> 5'-pApG-3' + H(+)
RHEA:19937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine
RHEA:19937	skos:altLabel	"glycine methyltransferase"
RHEA:19937	skos:prefLabel	"glycine N-methyltransferase"
RHEA:19937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine N-methyltransferase"
REACT:R-BTA-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Bos taurus)
RHEA:12553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA => (E)-pinosylvin + 4 CO2 + 4 CoA
REACT:R-MMU-192312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Mus musculus)
REACT:R-PFA-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Plasmodium falciparum)
REACT:R-MMU-888589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GABA at the synapse (Mus musculus)
RHEA:24296	skos:prefLabel	"dihydroorotase"
RHEA:24296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroorotase"
RHEA:24296	skos:altLabel	"DHOase"
RHEA:24296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate
RHEA:24296	skos:altLabel	"carbamoylaspartic dehydrase"
REACT:R-XTR-1112703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 is phosphorylated (Xenopus tropicalis)
REACT:R-DME-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Drosophila melanogaster)
REACT:R-HSA-8874194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L1 (Homo sapiens)
RHEA:39139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA
REACT:R-RNO-110248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 3-methyladenine by MPG glycosylase  (Rattus norvegicus)
REACT:R-MMU-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Mus musculus)
GO:0090682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled receptor bitter taste receptor activity
GO:0090682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled receptor bitter taste receptor activity
GO:0090682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR bitter taste receptor activity
REACT:R-BTA-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Bos taurus)
RHEA:15870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-alanine => D-glutamate + pyruvate
RHEA:60197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate
REACT:R-CFA-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Canis familiaris)
GO:0099567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels
GO:0099567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	postsynaptic calcium ion buffering
GO:0099567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering
GO:0099567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration
RHEA:23960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O2 + hexadecanoate = CO2 + 3 H2O + pentadecanal
RHEA:23960	skos:prefLabel	"fatty-acid peroxidase"
RHEA:23960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty-acid peroxidase"
RHEA:54148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene = 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O
RHEA:20042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H2O + NADP(+) => 2 H(+) + malonate + NADPH
RHEA:22728	skos:altLabel	"L-selenocysteinyl-tRNA(Sel) synthase"
RHEA:22728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate
RHEA:22728	skos:altLabel	"L-selenocysteinyl-tRNA(Sec) synthase"
RHEA:22728	skos:prefLabel	"L-seryl-tRNA(Sec) selenium transferase"
RHEA:22728	skos:altLabel	"cysteinyl-tRNA(Sec)-selenium transferase"
RHEA:22728	skos:altLabel	"selenocysteine synthase"
RHEA:22728	skos:altLabel	"cysteinyl-tRNA(Sel)-selenium transferase"
RHEA:22728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-seryl-tRNA(Sec) selenium transferase"
RHEA:43689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate => L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate
REACT:R-HSA-1112514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK activation (Homo sapiens)
REACT:R-DRE-382055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb7 binds to the active PDGF receptor (Danio rerio)
RHEA:51441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 => (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
RHEA:59493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate
REACT:R-SPO-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Schizosaccharomyces pombe)
REACT:R-XTR-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Xenopus tropicalis)
REACT:R-BTA-5654659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)
REACT:R-DDI-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Dictyostelium discoideum)
REACT:R-GGA-141159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-mediated dimerization of procaspase-8 (Gallus gallus)
REACT:R-MMU-443910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)
REACT:R-SSC-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Sus scrofa)
REACT:R-RNO-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)
RHEA:13887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + stipitatate => H2O + stipitatonate
RHEA:64044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine
REACT:R-DDI-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Dictyostelium discoideum)
RHEA:41144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-RNO-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
REACT:R-SSC-8847977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRK phosphorylates PTEN (Sus scrofa)
REACT:R-MMU-5607731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes p-7S-p100:RELB to form p52:RELB (Mus musculus)
REACT:R-SPO-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)
RHEA:33855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphophytoceramide + GDP + H(+)
REACT:R-BTA-265428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with VCAM1 (Bos taurus)
EC:3.6.1.8	skos:altLabel	"ATPase"
EC:3.6.1.8	skos:prefLabel	"ATP diphosphatase"
EC:3.6.1.8	skos:altLabel	"ATP pyrophosphatase"
EC:3.6.1.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ATP diphosphatase"
REACT:R-HSA-2168884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Methemoglobin to Hemopexin (Homo sapiens)
REACT:R-SSC-71286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Sus scrofa)
REACT:R-CFA-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Canis familiaris)
REACT:R-HSA-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
RHEA:47118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-eicosanoylglycinate => eicosanoate + glycine
GO:0010356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate geranylgeranyltransferase activity
REACT:R-SSC-448678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTSG cleaves CASP1(1-404) (Sus scrofa)
RHEA:55773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonate + an L-alpha-amino acid + ATP => a jasmonyl-L-amino acid + AMP + diphosphate + H(+)
REACT:R-DRE-5682607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Danio rerio)
REACT:R-BTA-9640175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Bos taurus)
REACT:R-GGA-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Gallus gallus)
GO:0004109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogenase activity
GO:0004109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen oxidase activity
GO:0004109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen-III oxidase activity
GO:0004109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coprogen oxidase activity
GO:0004109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
REACT:R-DRE-5693542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RPA complexes with ssDNA at resected DNA DSBs (Danio rerio)
RHEA:65421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP(in) + NAD(+)(out) => GMP(out) + NAD(+)(in)
REACT:R-DRE-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Danio rerio)
REACT:R-HSA-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Homo sapiens)
RHEA:20303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-arginyl-tRNA(Arg) => ATP + L-arginine + tRNA(Arg)
REACT:R-GGA-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Gallus gallus)
REACT:R-RNO-209821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of N-acetyl-5-HT to form melatonin (Rattus norvegicus)
RHEA:55555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine
RHEA:37975	skos:altLabel	"HPT"
RHEA:37975	skos:prefLabel	"homogentisate phytyltransferase"
RHEA:37975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homogentisate phytyltransferase"
RHEA:37975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + homogentisate + phytyl diphosphate = 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate
RHEA:70687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)
REACT:R-XTR-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Xenopus tropicalis)
RHEA:45217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] => Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-DRE-9034053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Danio rerio)
RHEA:69829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:11019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + H2O <=> (S)-ureidoglycolate + urea
RHEA:50028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine
REACT:R-CFA-8852331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 translocates to the nucleus (Canis familiaris)
REACT:R-RNO-2464809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates the transport of atROL from ROS to RPE (Rattus norvegicus)
REACT:R-DRE-70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)
REACT:R-CEL-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)
REACT:R-DRE-1964501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Danio rerio)
REACT:R-MMU-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Mus musculus)
RHEA:32562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> diphosphate + gamma-terpinene
REACT:R-BTA-174202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Securin (Bos taurus)
RHEA:12317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-CEL-888589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GABA at the synapse (Caenorhabditis elegans)
RHEA:10415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + H2O <=> AMP + D-ribose 5-phosphate + 2 H(+)
RHEA:19338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydroxylamine + 2 NAD(+) => 2 H(+) + hyponitrous acid + 2 NADH
REACT:R-GGA-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Gallus gallus)
REACT:R-CEL-354149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
REACT:R-CFA-389759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP-1 or SHP-2 with phospho PD-1 (Canis familiaris)
GO:0031877	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	somatostatin receptor ligand
GO:0031877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	somatostatin receptor binding
REACT:R-CEL-442749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
RHEA:54549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 1,5-bisphosphate + H2O => D-xylulose 5-phosphate + phosphate
REACT:R-DME-8851797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 in ADRB2:GRK complex is phosphorylated (Drosophila melanogaster)
RHEA:68407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-iso(homo)2citrate + NAD(+) <=> 2-oxoheptanedioate + CO2 + NADH
REACT:R-SSC-174731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of newly synthesized ApoB-48 (Sus scrofa)
REACT:R-HSA-373707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-1 induced DCC clustering (Homo sapiens)
REACT:R-HSA-445083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHL1 interacts with NRP1 (Homo sapiens)
RHEA:43281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate
RHEA:39782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-74743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-Y427-SHC1 from insulin receptor (Sus scrofa)
GO:0050159	skos:prefLabel	"orsellinate decarboxylase"
GO:0050159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orsellinate decarboxylase activity
GO:0050159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orsellinate carboxy-lyase (orcinol-forming)
GO:0050159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + orsellinate = CO2 + orcinol
GO:0050159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"orsellinate decarboxylase"
GO:0050159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orsellinate carboxy-lyase activity
GO:0050159	skos:altLabel	"orsellinate carboxy-lyase"
REACT:R-CFA-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Canis familiaris)
RHEA:71985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + fusoxypene B => (2E,6E,10E,14E)-geranylfarnesyl diphosphate
REACT:R-HSA-9622840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8 dissociates from LAMP2A-bound substrate (Homo sapiens)
RHEA:14533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"creatininase"
RHEA:14533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine + H2O = creatine
RHEA:14533	skos:altLabel	"Creatinine amidohydrolase"
RHEA:14533	skos:prefLabel	"creatininase"
RHEA:35310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + salicylate <=> 2,5-dihydroxybenzoate + H2O + NAD(+)
RHEA:35733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycerol 3-phosphate + CoA => sn-glycerol 3-phosphate + tetradecanoyl-CoA
REACT:R-XTR-71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer reduces PYR to LACT (Xenopus tropicalis)
RHEA:43704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + tetradecanoate = diphosphate + tetradecanoyl-AMP
REACT:R-HSA-187545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cks1 with SCF(Skp2) complex (Homo sapiens)
REACT:R-DRE-8855237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Danio rerio)
REACT:R-BTA-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Bos taurus)
RHEA:48311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O <=> (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)
GO:0004844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil DNA N-glycosylase activity
GO:0004844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil-DNA glycosylase activity
REACT:R-MMU-9029551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Mus musculus)
REACT:R-HSA-190263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3b binds to FGF (Homo sapiens)
RHEA:39304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA => (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O
RHEA:45131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)
REACT:R-BTA-264615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Bos taurus)
REACT:R-BTA-9621179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cinaciguat binds sGC:NO (Bos taurus)
RHEA:20012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose <=> H(+) + linamarin + UDP
RHEA:31314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)
RHEA:72847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate(in) + ADP(out) = adenosine 3',5'-bisphosphate(out) + ADP(in)
RHEA:23654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+) => N-terminal L-glutaminyl-[peptide]
REACT:R-HSA-9735775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)
REACT:R-DME-5687653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)
REACT:R-RNO-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Rattus norvegicus)
REACT:R-DME-8874705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Drosophila melanogaster)
RHEA:72237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in) => 2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out)
RHEA:45426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:63542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine + neurotensin-(1-12) => H2O + neurotensin
REACT:R-RNO-174931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Rattus norvegicus)
REACT:R-HSA-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)
REACT:R-XTR-159796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor IX to factor IX (Xenopus tropicalis)
REACT:R-DME-5654402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
RHEA:55461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Drosophila melanogaster)
RHEA:26511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-prolinamide => L-proline + NH4(+)
REACT:R-RNO-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
REACT:R-DME-8941543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Drosophila melanogaster)
REACT:R-HSA-6807229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
RHEA:67110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine
REACT:R-XTR-8853734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Xenopus tropicalis)
REACT:R-DRE-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Danio rerio)
REACT:R-CEL-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Caenorhabditis elegans)
REACT:R-CFA-937029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Canis familiaris)
RHEA:11797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone + O2 => 3-dehydroecdysone + H2O2
RHEA:22267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,6-trichloropyridin-2-ol + FADH2 + O2 <=> 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O
RHEA:35897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-SSC-5621354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Sus scrofa)
REACT:R-CEL-2060328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS1 (Caenorhabditis elegans)
RHEA:21312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gentisate decarboxylase"
RHEA:21312	skos:altLabel	"gentisate carboxy-lyase"
RHEA:21312	skos:altLabel	"2,5-dihydroxybenzoate decarboxylase"
RHEA:21312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxybenzoate + H(+) = CO2 + hydroquinone
RHEA:21312	skos:prefLabel	"gentisate decarboxylase"
REACT:R-RNO-5634228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 is cleaved by caspases (Rattus norvegicus)
REACT:R-HSA-9651467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 variant does not bind kallikrein (Homo sapiens)
REACT:R-CEL-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
RHEA:71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)
REACT:R-CEL-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Caenorhabditis elegans)
GO:0015215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide transmembrane transporter activity
GO:0043897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-D-glucan alpha-maltohydrolase activity
GO:0043897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltogenic alpha-amylase activity
GO:0043897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan 1,4-alpha-maltohydrolase"
GO:0043897	skos:altLabel	"maltogenic alpha-amylase"
GO:0043897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan 1,4-alpha-maltohydrolase activity
GO:0043897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan-1,4-alpha-maltohydrolase activity
GO:0043897	skos:prefLabel	"glucan 1,4-alpha-maltohydrolase"
GO:0033196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNPx activity
GO:0033196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryparedoxin peroxidase activity
REACT:R-SSC-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Sus scrofa)
RHEA:69213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate
REACT:R-HSA-9011975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive MYC gene expression (Homo sapiens)
RHEA:37349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-alanyl-(R)-lactate + phosphate => (R)-lactate + ATP + D-alanine
RHEA:28916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) + H(+)(in) => 4-aminobutanoate(out) + H(+)(out)
REACT:R-CFA-4641129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is ubiquitinated by SMURF2 (Canis familiaris)
REACT:R-CFA-2395965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)
REACT:R-RNO-6804527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INTL1 binds bacterial glycans (Rattus norvegicus)
RHEA:63595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:41219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)
REACT:R-MMU-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)
REACT:R-CEL-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Caenorhabditis elegans)
RHEA:37431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine
REACT:R-MMU-446391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the PINCH-ILK-parvin complex (Mus musculus)
REACT:R-BTA-2168038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XV restin release (Bos taurus)
REACT:R-CEL-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)
REACT:R-SSC-380278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Sus scrofa)
GO:0061896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans retinol 3,4-desaturase activity
GO:0061896	skos:prefLabel	"all-trans-retinol 3,4-desaturase"
GO:0061896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-retinol 3,4-desaturase"
GO:0061896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]
GO:0061896	skos:altLabel	"CYP27C1"
REACT:R-RNO-1250280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin (Rattus norvegicus)
RHEA:61152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
RHEA:34899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + S-adenosyl-L-methionine = malonyl-CoA methyl ester + S-adenosyl-L-homocysteine
REACT:R-XTR-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Xenopus tropicalis)
REACT:R-BTA-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Bos taurus)
REACT:R-SSC-8982617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB:O2 dissociates (Sus scrofa)
RHEA:24106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine => 7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA
REACT:R-CFA-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Canis familiaris)
REACT:R-HSA-9756948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-2S-SMAD2,3:SMAD4, p-2S-SMAD2,3:TRIM33, CTNNB1, EOMES, and TBPL2 bind FOXH1:SMAD3:GSC gene (Homo sapiens)
REACT:R-MMU-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)
REACT:R-DRE-8865454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX3 (Danio rerio)
REACT:R-SSC-8852351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 promotes translocation of TP53 to the cytosol (Sus scrofa)
RHEA:55616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carotenoid psi-end group = a carotenoid epsilon-end group
REACT:R-CEL-3781011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Caenorhabditis elegans)
RHEA:23491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-benzoquinone + H(+) + NADPH <=> hydroquinone + NADP(+)
RHEA:23593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NADP(+) => D-glyceraldehyde + H(+) + NADPH
REACT:R-RNO-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Rattus norvegicus)
REACT:R-GGA-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Gallus gallus)
REACT:R-BTA-5665767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FMNL3 binds G-actin (Bos taurus)
RHEA:31777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O
RHEA:15749	skos:altLabel	"MDH"
RHEA:15749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-mandelate + A = AH2 + phenylglyoxylate
RHEA:15749	skos:prefLabel	"(S)-mandelate dehydrogenase"
RHEA:15749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-mandelate dehydrogenase"
RHEA:15749	skos:altLabel	"L(+)-mandelate dehydrogenase"
REACT:R-GGA-5654615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:pFRS binds GRB2:SOS1 (Gallus gallus)
REACT:R-SSC-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-CFA-879411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Canis familiaris)
REACT:R-RNO-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Rattus norvegicus)
REACT:R-BTA-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Bos taurus)
REACT:R-CFA-8848314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36:IL1RL2 binds IL1RAP-1 (Canis familiaris)
RHEA:62023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sitosteryl 3-beta-D-glucoside <=> D-glucose + sitosterol
GO:0017176	skos:prefLabel	"phosphatidylinositol N-acetylglucosaminyltransferase"
GO:0017176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol N-acetylglucosaminyltransferase activity
GO:0017176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity
GO:0017176	skos:altLabel	"uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase"
GO:0017176	skos:altLabel	"UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase"
GO:0017176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol N-acetylglucosaminyltransferase"
GO:0017176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity
GO:0017176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity
GO:0017176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP
GO:0017176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity
RHEA:36444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochanoclavine-I aldehyde => 6,8-dimethyl-6,7-didehydroergoline + H2O
REACT:R-MMU-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Mus musculus)
REACT:R-DRE-9749471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 binds CHUK:IKBKB:IKBKG (Danio rerio)
REACT:R-SSC-9677320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS1 dimer binds PTGS1 Inhibitors (Sus scrofa)
REACT:R-CFA-2176491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L binds phosphorylated linker region of SMAD2/3 (Canis familiaris)
RHEA:42712	skos:altLabel	"5-methyluridine(54) tRNA methyltransferase"
RHEA:42712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(54) in tRNA = 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42712	skos:altLabel	"ribothymidyl synthase"
RHEA:42712	skos:altLabel	"tRNA(m(5)U(54))methyltransferase"
RHEA:42712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (uracil(54)-C(5))-methyltransferase"
RHEA:42712	skos:altLabel	"tRNA:m(5)U(54)-methyltransferase"
RHEA:42712	skos:altLabel	"tRNA(uracil-54,C(5))-methyltransferase"
RHEA:42712	skos:altLabel	"tRNA uracil(54) 5-methyltransferase"
RHEA:42712	skos:prefLabel	"tRNA (uracil(54)-C(5))-methyltransferase"
RHEA:42712	skos:altLabel	"RUMT"
RHEA:42712	skos:altLabel	"tRNA uracil 5-methyltransferase"
RHEA:42712	skos:altLabel	"transfer RNA uracil(54) 5-methyltransferase"
RHEA:42712	skos:altLabel	"m(5)U(54)-methyltransferase"
RHEA:42712	skos:altLabel	"transfer RNA uracil 5-methyltransferase"
RHEA:42712	skos:altLabel	"transfer RNA uracil(54) methylase"
RHEA:42712	skos:altLabel	"m5U-methyltransferase"
RHEA:42712	skos:altLabel	"transfer RNA uracil methylase"
REACT:R-XTR-8847995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERBB2 binds PTK6 (BRK) (Xenopus tropicalis)
REACT:R-DRE-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Danio rerio)
RHEA:12710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)
REACT:R-MMU-2537665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin-1 and -2 bind fibronectin (Mus musculus)
REACT:R-CEL-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Caenorhabditis elegans)
REACT:R-GGA-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Gallus gallus)
RHEA:10267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose <=> beta-D-glucose
REACT:R-MMU-141423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the MCC complex to the APC/C complex (Mus musculus)
REACT:R-BTA-5663050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHI and DHICA polymerise forming eumelanin (Bos taurus)
RHEA:31273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + NAD(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2
REACT:R-XTR-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Xenopus tropicalis)
RHEA:63702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolic acid O-acyl-beta-D-glucuronide + UDP => mycophenolate + UDP-alpha-D-glucuronate
REACT:R-DRE-517536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Danio rerio)
REACT:R-HSA-1855208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Homo sapiens)
REACT:R-XTR-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Xenopus tropicalis)
REACT:R-CEL-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Caenorhabditis elegans)
RHEA:16904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-2,4-diaminobutanoate <=> (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)
GO:0009030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin phosphate kinase activity
GO:0009030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin-monophosphate kinase activity
GO:0009030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin-phosphate kinase activity
GO:0009030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin monophosphokinase activity
GO:0009030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine-phosphate kinase activity
GO:0009030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:thiamine-phosphate phosphotransferase activity
GO:0009030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin monophosphatase activity
GO:0009030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine-monophosphate kinase activity
REACT:R-RNO-5693608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial resection of double-strand break ends (Rattus norvegicus)
RHEA:21246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine
REACT:R-RNO-1462041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNP1-4 are released into phagocytic vacuoles (Rattus norvegicus)
RHEA:55894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+) => a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2
RHEA:35763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-9021072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC7, ZDHHC21 palmitoylate ESR1 (Canis familiaris)
GO:0045514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-16 receptor binding
GO:0045514	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-16
GO:0045514	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-16 receptor ligand
RHEA:53709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + NADP(+) => (2E,4Z)-decadienoyl-CoA + H(+) + NADPH
REACT:R-HSA-9708423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1:BACH1:Hemes are transported out of the nucleus (Homo sapiens)
RHEA:39353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA
REACT:R-HSA-68918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
RHEA:53298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)
REACT:R-CFA-2179276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 monoubiquitinates SMAD3 (Canis familiaris)
REACT:R-CFA-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Canis familiaris)
RHEA:59086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose
RHEA:70849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-cysteine(in) + Na(+)(in) => L-arginine(in) + L-cysteine(out) + Na(+)(out)
REACT:R-GGA-201457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP2 binds to the receptor complex (Gallus gallus)
REACT:R-BTA-8956031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Bos taurus)
REACT:R-BTA-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Bos taurus)
RHEA:58149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl acetate + H2O => acetate + ethanol + H(+)
REACT:R-HSA-399933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sema3A binds Nrp-1 bound to PlexinA (Homo sapiens)
REACT:R-MMU-109822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Mus musculus)
RHEA:29993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-lyxopyranose(out) => H(+)(in) + L-lyxopyranose(in)
REACT:R-HSA-914018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Homo sapiens)
REACT:R-RNO-982810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation (Rattus norvegicus)
REACT:R-DRE-8933328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYPLA2 hydrolyses PALM-C3,4-GAP43 (Danio rerio)
REACT:R-HSA-8938217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SWI/SNF complex (Homo sapiens)
REACT:R-XTR-1236956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfment of particulate antigen into phagocytic vesicle (Xenopus tropicalis)
REACT:R-RNO-6805507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 binds AVEN (Rattus norvegicus)
REACT:R-RNO-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Rattus norvegicus)
RHEA:58391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + all-trans-hexaprenyl diphosphate <=> 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate
RHEA:38761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
REACT:R-GGA-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Gallus gallus)
REACT:R-GGA-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Gallus gallus)
REACT:R-BTA-9611852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB3 bind ADR,NAd (Bos taurus)
RHEA:53841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH
REACT:R-CEL-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Caenorhabditis elegans)
REACT:R-BTA-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Bos taurus)
REACT:R-CFA-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Canis familiaris)
GO:0004067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	elspar
GO:0004067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-asparaginase activity
GO:0004067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	crasnitin
GO:0004067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparaginase II
GO:0004067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparaginase activity
GO:0004067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	colaspase activity
GO:0004067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leunase activity
GO:0004067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-asparaginase activity
GO:0004067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-asparagine amidohydrolase activity
REACT:R-HSA-2534260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)
REACT:R-HSA-8949659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Homo sapiens)
RHEA:29438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin(in) + H(+)(out) <=> enterobactin(out) + H(+)(in)
REACT:R-SSC-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Sus scrofa)
REACT:R-DRE-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Danio rerio)
REACT:R-RNO-9756134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Rattus norvegicus)
RHEA:56876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N-acetyl-1-phenylethylamine + H2O = (R)-1-phenylethylamine + acetate
RHEA:36411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + hnu = calciol
REACT:R-SSC-3791319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NID1 degradation by MMP19 (Sus scrofa)
RHEA:33182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)
RHEA:48226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O
RHEA:55783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate <=> all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP
REACT:R-HSA-606349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mis18 complex binds the centromere (Homo sapiens)
RHEA:62975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + orsellinate
REACT:R-MMU-500717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GRIK3 homomer (Mus musculus)
RHEA:31267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexanoate + NADP(+) = 6-oxohexanoate + H(+) + NADPH
GO:0047734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPglycerol diphosphatase activity
GO:0047734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glycerol diphosphatase activity
GO:0047734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoglycerol pyrophosphatase activity
GO:0047734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPglycerol phosphoglycerohydrolase activity
GO:0047734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-glycerol phosphoglycerohydrolase activity
GO:0047734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glycerol pyrophosphatase activity
GO:0047734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPglycerol pyrophosphatase activity
REACT:R-RNO-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Rattus norvegicus)
REACT:R-DRE-3781024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Danio rerio)
RHEA:56069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP
RHEA:18846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NAD(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADH
RHEA:12305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H2O + NADP(+) => 2 H(+) + L-2-aminoadipate + NADPH
RHEA:62289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate
REACT:R-SSC-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Sus scrofa)
REACT:R-CFA-69299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds geminin (Canis familiaris)
RHEA:13194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
REACT:R-HSA-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Homo sapiens)
RHEA:43170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine(34) in tRNA + NH4(+) => adenosine(34) in tRNA + H(+) + H2O
REACT:R-DME-8876615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB13 GEFs exchange GTP for GDP on RAB13 (Drosophila melanogaster)
REACT:R-MMU-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Mus musculus)
RHEA:20860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,6R)-isopiperitenol + NAD(+) = (6R)-isopiperitenone + H(+) + NADH
RHEA:20860	skos:prefLabel	"isopiperitenol dehydrogenase"
RHEA:20860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopiperitenol dehydrogenase"
REACT:R-SPO-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Schizosaccharomyces pombe)
REACT:R-CEL-5661115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Caenorhabditis elegans)
REACT:R-HSA-9629365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to spiroiminodihydantoin (Homo sapiens)
REACT:R-SCE-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Saccharomyces cerevisiae)
REACT:R-BTA-2393954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
RHEA:50873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 => (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate
REACT:R-RNO-209055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)
REACT:R-DME-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
REACT:R-SSC-451942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Within the IL-2R complex JAK3 phosphorylates JAK1 (Sus scrofa)
REACT:R-SSC-5690701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 binds p-CD22 (Sus scrofa)
REACT:R-SSC-5635839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3:SUFU dissociates (Sus scrofa)
REACT:R-MMU-140847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Mus musculus)
RHEA:32834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an R-cob(III)alamin(in) <=> an R-cob(III)alamin(out)
RHEA:67525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine
RHEA:10226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal
RHEA:47431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) <=> 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH
GO:0102103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethoxycurcumin synthase
REACT:R-HSA-975853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)
REACT:R-GGA-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Gallus gallus)
REACT:R-SPO-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Schizosaccharomyces pombe)
GO:0140410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:bicarbonate symporter activity
RHEA:69533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate => 4-amino-4-deoxychorismate
REACT:R-GGA-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Gallus gallus)
REACT:R-GGA-9029667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DFF dissociates from importin-alpha:importin-beta (Gallus gallus)
REACT:R-CFA-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Canis familiaris)
RHEA:51246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2
REACT:R-CEL-9615249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBs bind AGRT1 (Caenorhabditis elegans)
REACT:R-GGA-983421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Journey of cargo through Golgi complex (Gallus gallus)
RHEA:11395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4-trisphosphate + phosphate
EC:3.4.22.27	skos:prefLabel	"cathepsin S"
EC:3.4.22.27	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin S"
RHEA:58866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2
REACT:R-CFA-5668735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX3 complex (Canis familiaris)
RHEA:72394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + oxalate(in) <=> 2 hydrogencarbonate(in) + oxalate(out)
RHEA:70214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose <=> (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose
REACT:R-GGA-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Gallus gallus)
REACT:R-DME-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Drosophila melanogaster)
REACT:R-BTA-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Bos taurus)
RHEA:16963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline + L-lysine => epsilon-(gamma-L-glutamyl)-L-lysine
RHEA:72505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + prostaglandin F2alpha(in) => glutarate(in) + prostaglandin F2alpha(out)
RHEA:29632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraose + H2O => alpha-D-glucose + D-maltotriose
REACT:R-MMU-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Mus musculus)
REACT:R-HSA-983285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B binds RAD51C (Homo sapiens)
RHEA:27958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + H2O = cytosine + D-ribose
RHEA:13798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + H2O => di-trans,poly-cis-dolichol + phosphate
REACT:R-MMU-5627072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds GOPC:CFTR (Mus musculus)
REACT:R-MMU-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)
REACT:R-HSA-6810139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA2 chromatin is activated (Homo sapiens)
REACT:R-CFA-210974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS-1 to Tie2 bound  Grb2 (Canis familiaris)
REACT:R-GGA-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)
REACT:R-HSA-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)
REACT:R-HSA-8936599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter (Homo sapiens)
REACT:R-DME-8938073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Drosophila melanogaster)
REACT:R-MMU-143468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEOS oxidizes ethanol to acetaldehyde (Mus musculus)
REACT:R-XTR-265428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with VCAM1 (Xenopus tropicalis)
RHEA:48981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dichlorocatechol + O2 => (2Z,4Z)-2,3-dichloromuconate + 2 H(+)
REACT:R-CFA-1605723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Canis familiaris)
REACT:R-DDI-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Dictyostelium discoideum)
REACT:R-HSA-198347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates BAD (Homo sapiens)
REACT:R-MMU-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Mus musculus)
REACT:R-XTR-71541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Xenopus tropicalis)
REACT:R-RNO-983425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Rattus norvegicus)
REACT:R-DRE-1306957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Danio rerio)
REACT:R-MMU-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Mus musculus)
RHEA:68992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4-hydroxybenzoate + H(+) + NADPH + O2 = 3-amino-2,4-dihydroxybenzoate + H2O + NADP(+)
RHEA:68992	skos:prefLabel	"3-amino-4-hydroxybenzoate 2-monooxygenase"
RHEA:68992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-amino-4-hydroxybenzoate 2-monooxygenase"
GO:0106436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-dependent sulfide quinone oxidoreductase activity
GO:0106436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	eukaryotic sulfide quinone oxidoreductase
REACT:R-SCE-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Saccharomyces cerevisiae)
REACT:R-DME-9653585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Farn-Me KRAS4B binds calmodulin (Drosophila melanogaster)
REACT:R-CEL-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Caenorhabditis elegans)
RHEA:53721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate
REACT:R-HSA-4084903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types VI, IX bind integrin alpha10beta1 (Homo sapiens)
GO:0008271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfate porter activity
GO:0008271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secondary active sulphate transmembrane transporter activity
GO:0008271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphate porter activity
GO:0008271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secondary active sulfate transmembrane transporter activity
REACT:R-RNO-1295634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is serine phosphorylated in response to MAPK activation (Rattus norvegicus)
RHEA:14062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(carboxymethyl)-D-alanine + NAD(+) => glycine + H(+) + NADH + pyruvate
RHEA:15934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-propane-1,2-diol + NAD(+) => (S)-lactaldehyde + H(+) + NADH
REACT:R-GGA-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Gallus gallus)
RHEA:30890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin <=> 7,8-dihydropteroate + H2O
RHEA:13436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + H(+) + H2O <=> 2'-deoxyuridine + NH4(+)
REACT:R-DRE-69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Danio rerio)
RHEA:48572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dichlorocatechol + O2 = (2E,4E)-2,4-dichloromuconate + 2 H(+)
REACT:R-BTA-8944223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type V (Bos taurus)
RHEA:30790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine
REACT:R-CFA-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Canis familiaris)
REACT:R-SCE-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Saccharomyces cerevisiae)
REACT:R-SCE-209792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylation of serotonin (Saccharomyces cerevisiae)
REACT:R-RNO-6804879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates TP53 (Rattus norvegicus)
REACT:R-DDI-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Dictyostelium discoideum)
REACT:R-GGA-5668534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Gallus gallus)
REACT:R-GGA-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Gallus gallus)
REACT:R-DRE-6797810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAPL1 (Danio rerio)
REACT:R-DDI-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Dictyostelium discoideum)
REACT:R-CFA-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)
REACT:R-HSA-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Homo sapiens)
REACT:R-XTR-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Xenopus tropicalis)
REACT:R-HSA-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Homo sapiens)
RHEA:40308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + decanedioyl-CoA => (2E)-decenedioyl-CoA + AH2
REACT:R-SSC-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Sus scrofa)
REACT:R-CEL-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Caenorhabditis elegans)
REACT:R-DRE-140872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Danio rerio)
RHEA:42060	skos:prefLabel	"11-cis-retinol dehydrogenase"
RHEA:42060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH
RHEA:42060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"11-cis-retinol dehydrogenase"
RHEA:42060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + NAD(+) = 11-cis-retinal + H(+) + NADH
REACT:R-DRE-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Danio rerio)
REACT:R-HSA-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Homo sapiens)
REACT:R-DRE-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Danio rerio)
REACT:R-DRE-6810234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Danio rerio)
RHEA:45651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
GO:0015306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialate:cation symporter activity
GO:0015306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialate/cation symporter activity
GO:0015306	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sialate transporter activity
GO:0015306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation/sialate symporter activity
GO:0015306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation:sialate symporter activity
RHEA:16880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine + H(+) <=> CO2 + hypotaurine
RHEA:63934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisate(out) + ADP + H(+) + phosphate => abscisate(in) + ATP + H2O
GO:0000830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol hexakisphosphate 4-kinase activity
REACT:R-RNO-5621363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)
GO:0004037	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	allantoate amidinohydrolase activity
GO:0004037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoicase activity
GO:0004037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoine amidinohydrolase activity
REACT:R-MMU-8950766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA dimerizes (Mus musculus)
REACT:R-BTA-708349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD2 oligomerizes (Bos taurus)
RHEA:24020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"argininosuccinate lyase"
RHEA:24020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine
RHEA:24020	skos:altLabel	"arginosuccinase"
RHEA:24020	skos:altLabel	"N-(L-argininosuccinate) arginine-lyase"
RHEA:24020	skos:altLabel	"omega-N-(L-arginino)succinate arginine-lyase"
RHEA:24020	skos:prefLabel	"argininosuccinate lyase"
REACT:R-CFA-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
REACT:R-HSA-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Homo sapiens)
REACT:R-DRE-444572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zinc is an agonist of GPR39 (Danio rerio)
REACT:R-BTA-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Bos taurus)
RHEA:39444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)
RHEA:38683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sphing-4-enine(in) = ADP + H(+) + phosphate + sphing-4-enine(out)
REACT:R-GGA-5432849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds TLR4:LY96 (Gallus gallus)
REACT:R-SSC-5218905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Sus scrofa)
RHEA:30761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + thymine => 5-methylcytosine + H(+) + H2O
RHEA:28210	skos:prefLabel	"L-saccharopine oxidase"
RHEA:28210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-saccharopine oxidase"
RHEA:28210	skos:altLabel	"FAP2"
RHEA:28210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate
RHEA:49026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminio-3-(indol-3-yl)propanoate + H2O2 => L-tryptophan + O2
REACT:R-CFA-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Canis familiaris)
RHEA:25196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-methylcatechol + H(+) + NADH
RHEA:59479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + 2 ATP + benzoate + L-phenylalanine <=> 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol
REACT:R-RNO-9029667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DFF dissociates from importin-alpha:importin-beta (Rattus norvegicus)
REACT:R-MMU-5250209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP binds SLC25A4 (Mus musculus)
RHEA:53830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate => 2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2
REACT:R-CEL-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)
REACT:R-DME-352191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A8-mediated uptake of neutral amino acids (Drosophila melanogaster)
RHEA:47465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-tetradecadienoyl-CoA => (2E,5Z)-tetradecadienoyl-CoA
REACT:R-SSC-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Sus scrofa)
RHEA:19330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuatigenin + UDP-alpha-D-glucose => H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP
RHEA:72655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine + NADPH + O2 = 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)
REACT:R-MMU-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Mus musculus)
RHEA:44497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine => 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine
GO:0008502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melatonin receptor activity
REACT:R-DDI-110376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Dictyostelium discoideum)
RHEA:50429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanethiol + S-adenosyl-L-methionine => dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine
RHEA:23939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH
REACT:R-GGA-8964333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Gallus gallus)
RHEA:57838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal + H2O2 + spermidine => H2O + O2 + thermospermine
REACT:R-SSC-5635859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU dissociates (Sus scrofa)
RHEA:28913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-lysine(in) => H(+)(out) + L-lysine(out)
RHEA:61271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminohexanoate + O2 <=> 2-oxohexanoate + H2O2 + NH4(+)
REACT:R-XTR-1606839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Steryl sulfatase hydrolyses sulfate from steroid sulfates (Xenopus tropicalis)
EC:2.3.2.33	skos:prefLabel	"RCR-type E3 ubiquitin transferase"
EC:2.3.2.33	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RCR-type E3 ubiquitin transferase"
EC:2.3.2.33	skos:altLabel	"PHR1"
EC:2.3.2.33	skos:altLabel	"MYCBP2"
RHEA:42541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(13) in tRNA => pseudouridine(13) in tRNA
REACT:R-SCE-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Saccharomyces cerevisiae)
REACT:R-GGA-9757578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDN (Gallus gallus)
RHEA:51141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate
REACT:R-SSC-444848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 1 binds relaxin 3 (Sus scrofa)
REACT:R-XTR-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Xenopus tropicalis)
REACT:R-DME-188979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Drosophila melanogaster)
REACT:R-XTR-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Xenopus tropicalis)
REACT:R-DME-6799431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds HIPK1 (Drosophila melanogaster)
RHEA:55322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein] => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]
RHEA:57433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] => 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
RHEA:44790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-11 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-11 + S-adenosyl-L-methionine
RHEA:11565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-beta-D-glucopyranosyl-D-gluconate + phosphate => alpha-D-glucose 1-phosphate + D-gluconate
REACT:R-HSA-5696914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP28 deubiquitinates CLSPN and MYC (Homo sapiens)
REACT:R-HSA-1912357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH ubiquitinates DTX (Homo sapiens)
RHEA:32701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-sesquiphellandrene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-DRE-8875817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates STAT3 (Danio rerio)
REACT:R-RNO-75187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)
REACT:R-HSA-9670417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs downstream of KIT mutants (Homo sapiens)
REACT:R-CFA-114600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Canis familiaris)
RHEA:23064	skos:altLabel	"sulfate starvation-induced protein 6"
RHEA:23064	skos:prefLabel	"alkanesulfonate monooxygenase"
RHEA:23064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkanesulfonate monooxygenase"
RHEA:23064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + 2 H(+) + H2O + sulfite
RHEA:23064	skos:altLabel	"FMNH2-dependent aliphatic sulfonate monooxygenase"
REACT:R-HSA-6804485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)
REACT:R-MMU-8949580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F1Fo ATP synthase dimerizes (Mus musculus)
REACT:R-RNO-2396606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)
REACT:R-DRE-751019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:G12/13 complex dissociates (Danio rerio)
RHEA:21225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-choline + sphing-4-enine => CMP + H(+) + sphing-4-enine-phosphocholine
RHEA:12722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-methyl-5'-thioadenosine + spermidine
RHEA:22207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)
REACT:R-MMU-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Mus musculus)
REACT:R-MMU-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Mus musculus)
RHEA:46121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + H(+) + NADH + O2 <=> formaldehyde + H2O + methanethiol + NAD(+)
REACT:R-MMU-3222259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF20 binds TP53 dimethylated on K370 and K382 (Mus musculus)
RHEA:56749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose = NADP(+) + UDP-beta-L-rhamnose
REACT:R-HSA-191763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP:Snurportin complex formation (Homo sapiens)
RHEA:19840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol 6-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH
REACT:R-CEL-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Caenorhabditis elegans)
REACT:R-DRE-380901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked serotonin loaded synaptic vesicle (Danio rerio)
REACT:R-DDI-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)
REACT:R-HSA-9694555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein M localizes to the Golgi membrane (Homo sapiens)
REACT:R-RNO-9024983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Rattus norvegicus)
REACT:R-HSA-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Homo sapiens)
EC:2.1.1.67	skos:prefLabel	"thiopurine S-methyltransferase"
EC:2.1.1.67	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiopurine S-methyltransferase"
RHEA:67635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] <=> a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:64613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Gln) => AMP + diphosphate + L-glutamyl-tRNA(Gln)
REACT:R-CEL-1889981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Caenorhabditis elegans)
REACT:R-CEL-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)
REACT:R-DRE-193401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)
REACT:R-HSA-375302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules (Homo sapiens)
REACT:R-SCE-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Saccharomyces cerevisiae)
GO:0050053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity
GO:0050053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-2,6-fructan:D-glucose 1-fructosyltransferase activity
GO:0050053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	levansucrase activity
GO:0050053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-2,6-fructosyltransferase activity
GO:0050053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose 6-fructosyl transferase activity
GO:0050053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose 6-fructosyltransferase activity
GO:0016618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxypyruvate reductase activity
GO:0016618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glycerate:NADP+ 2-oxidoreductase activity
GO:0016618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:hydroxypyruvate reductase activity
GO:0016618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxypyruvate reductase activity
GO:0016618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glycerate dehydrogenase activity
GO:0034899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine monooxygenase activity
REACT:R-XTR-8954082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds the PRC1 complex (Xenopus tropicalis)
REACT:R-SSC-5617828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIP11:IFT20 dissociates (Sus scrofa)
RHEA:46593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]
REACT:R-CFA-8849082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 stimulates RHOA GTPase activity (Canis familiaris)
REACT:R-GGA-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)
RHEA:51661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 => an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)
RHEA:17145	skos:altLabel	"2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase"
RHEA:17145	skos:altLabel	"HDR"
RHEA:17145	skos:prefLabel	"2'-hydroxydaidzein reductase"
RHEA:17145	skos:altLabel	"NADPH:2'-hydroxydaidzein oxidoreductase"
RHEA:17145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxy-2,3-dihydrodaidzein + NADP(+) = 2'-hydroxydaidzein + 2 H(+) + NADPH
RHEA:17145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-hydroxydaidzein reductase"
GO:0034570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymonomethylisoproturon dimethylaminedehydrogenase activity
REACT:R-SSC-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Sus scrofa)
RHEA:21390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine => H2O + L-2-aminohexano-6-lactam
REACT:R-PFA-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Plasmodium falciparum)
RHEA:59443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)
REACT:R-SSC-216050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Sus scrofa)
REACT:R-HSA-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Homo sapiens)
RHEA:71139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH = 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)
RHEA:44364	skos:prefLabel	"2-epi-5-epi-valiolone 7-kinase"
RHEA:44364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone + ATP = 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)
RHEA:44364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-epi-5-epi-valiolone 7-kinase"
REACT:R-CFA-5617816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A  (Canis familiaris)
REACT:R-MMU-5696365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Mus musculus)
REACT:R-DDI-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)
REACT:R-SSC-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Sus scrofa)
REACT:R-DRE-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Danio rerio)
EC:5.6.1.2	skos:altLabel	"dynein adenosine 5'-triphosphatase"
EC:5.6.1.2	skos:prefLabel	"dynein ATPase"
EC:5.6.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dynein ATPase"
REACT:R-RNO-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Rattus norvegicus)
REACT:R-CFA-114254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS binds to APAF1 (Canis familiaris)
RHEA:65001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[ACP] + octanoyl-AMP => AMP + H(+) + octanoyl-[ACP]
REACT:R-SPO-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Schizosaccharomyces pombe)
RHEA:57360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADH = (6R)-NADHX
GO:0090499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pimelyl-[acyl-carrier protein] methyl ester hydrolase activity
GO:0090499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pimelyl-[acyl-carrier protein] methyl ester esterase activity
REACT:R-SSC-446701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4-activated IRAK1 autophosphorylates (Sus scrofa)
RHEA:35095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choline trimethylamine-lyase"
RHEA:35095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline = acetaldehyde + trimethylamine
RHEA:35095	skos:prefLabel	"choline trimethylamine-lyase"
GO:0036524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein deglycating enzyme
GO:0036524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein deglycase activity
REACT:R-MMU-996727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST recruits the BHC complex (Mus musculus)
RHEA:59915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H2O + NADP(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH
RHEA:34849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromonapterin + NADP(+) => 7,8-dihydromonapterin + H(+) + NADPH
REACT:R-SSC-3247569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADI4 deiminates Histones (Sus scrofa)
REACT:R-MMU-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Mus musculus)
REACT:R-GGA-6811423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Gallus gallus)
REACT:R-DRE-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Danio rerio)
GO:0034799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydride TNP tautomerase activity
REACT:R-HSA-6799722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 oxidoreductase generates unstable semiquinones (Homo sapiens)
GO:0004993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine receptor
GO:0004993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT receptor
GO:0004993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled serotonin receptor activity
GO:0004993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled serotonin receptor activity
GO:0004993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled serotonin receptor activity
RHEA:28612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+) + XMP => H2O + XTP
REACT:R-DRE-1482629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)
REACT:R-RNO-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Rattus norvegicus)
REACT:R-DRE-75187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL receptor trimers bind FADD (Danio rerio)
REACT:R-BTA-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
RHEA:12134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Cd(2+)(out) + H(+) + phosphate => ATP + Cd(2+)(in) + H2O
REACT:R-HSA-9694345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein translocates to the nucleolus (Homo sapiens)
REACT:R-CEL-9688831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK3 at K55, K363 (Caenorhabditis elegans)
REACT:R-HSA-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Homo sapiens)
REACT:R-DRE-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Danio rerio)
REACT:R-MMU-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Mus musculus)
RHEA:22453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n+1) + n H2O => n H(+) + (n+1) phosphate
REACT:R-HSA-167098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)
REACT:R-RNO-8851908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 (Rattus norvegicus)
REACT:R-CFA-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Canis familiaris)
REACT:R-CFA-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Canis familiaris)
REACT:R-MMU-209772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to triiodothyronine (Mus musculus)
RHEA:62337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP => adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)
REACT:R-SPO-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Schizosaccharomyces pombe)
RHEA:38888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexanoyl-sphinganine => hexanoate + sphinganine
REACT:R-SSC-5686587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates RAD52 (Sus scrofa)
REACT:R-MMU-975139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Mus musculus)
REACT:R-SSC-2730886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC by SYK kinase (Sus scrofa)
RHEA:25943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-chloroquinoline + A + H2O <=> 8-chloroquinolin-2(1H)-one + AH2
RHEA:18012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]
REACT:R-XTR-1454791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP7, MMP9 bind CD44 (Xenopus tropicalis)
RHEA:22254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + H(+) + UDP => globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine
RHEA:68703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
GO:0140816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone-serine ADP-ribosyltransferase activity (H2B-S6 specific)
GO:0140816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone H2BS6 serine ADP-ribosyltransferase activity
GO:0140816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone H2B-S6 serine ADP-ribosyltransferase activity
REACT:R-MMU-9645394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Mus musculus)
RHEA:68255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan(in) + Na(+)(in) <=> L-tryptophan(out) + Na(+)(out)
REACT:R-MMU-5362441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Mus musculus)
REACT:R-DDI-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)
RHEA:40823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate
REACT:R-XTR-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Xenopus tropicalis)
RHEA:48837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
RHEA:67090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + tetracosanoate(out) => ATP + H2O + tetracosanoate(in)
REACT:R-DRE-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Danio rerio)
REACT:R-BTA-4641205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPO:LGR binds ZNRF3 (Bos taurus)
GO:0102406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	omega-hydroxypalmitate O-sinapoyl transferase activity
REACT:R-BTA-2997616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Bos taurus)
REACT:R-SSC-888614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO2 dioxygenates L-Trp to NFK (Sus scrofa)
REACT:R-BTA-909724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IFNAR1 (Bos taurus)
REACT:R-DME-9667965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds PP2A (Drosophila melanogaster)
REACT:R-MMU-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Mus musculus)
REACT:R-DRE-6781897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP11 deubiquitinates NFKBIA (Danio rerio)
RHEA:64633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + butan-1-ol => butyl acetate + CoA
GO:0016524	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	latrophilin
GO:0016524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	latrotoxin receptor activity
RHEA:47106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + L-serine => 5,10-methylenetetrahydromethanopterin + glycine + H2O
RHEA:42957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(38) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:34437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine => 4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine
RHEA:14126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 raffinose => 1(F)-alpha-D-galactosylraffinose + sucrose
RHEA:60388	skos:prefLabel	"iron(III) salmochelin esterase"
RHEA:60388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)
RHEA:60388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"iron(III) salmochelin esterase"
REACT:R-XTR-5686301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 binds SFTPAs (Xenopus tropicalis)
RHEA:42779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:63766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-GGA-1604731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP3 (Gallus gallus)
REACT:R-PFA-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Plasmodium falciparum)
REACT:R-BTA-209944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D binds GC (Bos taurus)
REACT:R-CEL-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)
REACT:R-HSA-9613207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1 binds to the EGR1 promoter (Homo sapiens)
RHEA:30907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) = 2-methylbutanoyl-CoA + CO2 + NADH
REACT:R-CEL-4755494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Caenorhabditis elegans)
RHEA:56628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O = chloride + 2 H(+) + maleylacetate
REACT:R-BTA-964811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5AR2 binds anaphylatoxins and thier desArginated derivatives (Bos taurus)
REACT:R-DRE-8982617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB:O2 dissociates (Danio rerio)
RHEA:69056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-methyl-L-arginine + NADH + O2 = H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)
RHEA:14452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + NADP(+) <=> 3,8-divinyl chlorophyllide a + H(+) + NADPH
REACT:R-BTA-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Bos taurus)
REACT:R-CFA-879934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)
GO:0052629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
RHEA:10961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate => (R)-lactate
REACT:R-MMU-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Mus musculus)
GO:0070968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQQ binding
GO:0070968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrroloquinoline quinone binding
GO:0018644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toluene 2-monooxygenase activity
REACT:R-HSA-9656252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective OGG1 mutants do not excise FapyG (Homo sapiens)
REACT:R-CFA-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Canis familiaris)
REACT:R-MMU-8876616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND6A,B exchange GTP for GDP on RAB14 (Mus musculus)
REACT:R-RNO-5635860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Rattus norvegicus)
RHEA:69441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) => 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH
REACT:R-HSA-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Homo sapiens)
REACT:R-HSA-5672969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF (Homo sapiens)
RHEA:59028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-GGA-975629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11 reduces RBP2:atRAL to RBP2:atROL (Gallus gallus)
RHEA:25823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermidine <=> 4-aminobutanal + H2O2 + propane-1,3-diamine
RHEA:15727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascopyrone M + H2O => 1,5-anhydro-D-fructose
RHEA:39704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH => (13Z)-eicosenoyl-CoA + NADP(+)
RHEA:30199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:65395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH <=> (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)
REACT:R-RNO-194718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Rattus norvegicus)
REACT:R-RNO-140840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Rattus norvegicus)
GO:0086060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in AV node cell action potential
GO:0086060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential
GO:0086060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential
REACT:R-DRE-5683986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APBB1 and MAPK8 bind diphosphorylated H2AFX (Danio rerio)
REACT:R-RNO-5676598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:cIAP1/2 complex binds FN14:TWEAK (Rattus norvegicus)
REACT:R-SSC-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Sus scrofa)
RHEA:12389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formononetin + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5696997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP24 deubiquitinates DDB2 (Mus musculus)
RHEA:48077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde
RHEA:64664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)
REACT:R-HSA-9770063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1,S2 Dissociate from S1:ACE2:S2 (Homo sapiens)
RHEA:30803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + H2O + NADP(+) = 4-aminobutanoate + 2 H(+) + NADPH
REACT:R-BTA-5690080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP3,SAGA deubiquitinate Histone H2A,H2B (Bos taurus)
REACT:R-CFA-2160851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAS1,2,3 mediate the polymerisation of HA (Canis familiaris)
REACT:R-CFA-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Canis familiaris)
REACT:R-RNO-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)
RHEA:40559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-evernosamine + NADPH + O2 = dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)
REACT:R-MMU-5577213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Mus musculus)
REACT:R-CEL-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Caenorhabditis elegans)
RHEA:67078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine
RHEA:49384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-198983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NKG2D homodimer interacting with ligands (Bos taurus)
REACT:R-DRE-4085372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO2,3 (Danio rerio)
GO:0140804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+- protein-lysine ADP-ribosyltransferase activity
GO:0140804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide
RHEA:47674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+)
RHEA:36140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hexadec-2-enoate + ATP + CoA => (2E)-hexadecenoyl-CoA + AMP + diphosphate
REACT:R-HSA-1482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by HADH (IM) (Homo sapiens)
REACT:R-BTA-1067688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)
RHEA:49497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane
RHEA:39253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoyl-CoA + NADP(+) => (2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH
RHEA:19818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH
RHEA:67559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + glycocholate <=> adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)
RHEA:57226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-(1-hydroxy-2-oxoethyl)-GTP => glyoxal + GTP
RHEA:68207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoylglycerol + octadecanoyl-CoA <=> 1,2-dihexanoyl-3-octadecanoylglycerol + CoA
GO:0010429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-CpNpN binding
REACT:R-BTA-8938913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF1 (Bos taurus)
REACT:R-DRE-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Danio rerio)
RHEA:55731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate
REACT:R-SSC-9650165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers bind H+ (Sus scrofa)
GO:0070840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynein complex binding
GO:0070840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dynein binding
RHEA:36499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD(+))"
RHEA:36499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-rhamnonate + NAD(+) = 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH
RHEA:36499	skos:altLabel	"2-keto-3-deoxy-L-rhamnonate dehydrogenase"
RHEA:36499	skos:prefLabel	"2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD(+))"
RHEA:44330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + octanoate => 1-octanoylglycerol + H2O
RHEA:55209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine 1-phosphate => (2R)-hydroxyhexadecanal + phosphoethanolamine
REACT:R-MMU-6781899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds SIAH2 (Mus musculus)
REACT:R-MMU-8851797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 in ADRB2:GRK complex is phosphorylated (Mus musculus)
RHEA:15555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 4-phosphate + phosphate => 1D-myo-inositol 1,4-bisphosphate + H2O
REACT:R-CEL-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Caenorhabditis elegans)
RHEA:22752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + uracil = AH2 + barbiturate + H(+)
RHEA:29362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UMP <=> phosphate + uridine
REACT:R-HSA-5617672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB3 gene is transcribed (Homo sapiens)
REACT:R-XTR-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Xenopus tropicalis)
RHEA:40654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-HSA-3322014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-a (Homo sapiens)
REACT:R-CFA-9709406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to Cytochrome c oxidase (Canis familiaris)
REACT:R-MMU-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)
REACT:R-MMU-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Mus musculus)
REACT:R-CFA-190413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2c (Canis familiaris)
REACT:R-MMU-444773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-TM7 receptors bind chondroitin sulphate (Mus musculus)
REACT:R-HSA-8950175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Glutathione S-transferase omega-1 (Homo sapiens)
REACT:R-RNO-8953037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F8 forms homodimers (Rattus norvegicus)
REACT:R-GGA-372910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + NADH + H+ <=> lactate + NAD+ (Gallus gallus)
RHEA:68821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + H2O => (6E)-nerolidol + diphosphate
REACT:R-SSC-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Sus scrofa)
RHEA:68572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine(in) = L-tyrosine(out)
REACT:R-CFA-2028284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Canis familiaris)
RHEA:18978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + sn-glycerol 3-phosphate => a quinol + dihydroxyacetone phosphate
REACT:R-GGA-5626981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Gallus gallus)
REACT:R-SSC-4093329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SDCBP (Sus scrofa)
REACT:R-HSA-8934735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 arginine-methylates RUNX1 (Homo sapiens)
REACT:R-SSC-165162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TSC2 by PKB (Sus scrofa)
RHEA:61298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-ribulose 1-phosphate => 5-deoxy-alpha-D-ribose 1-phosphate
REACT:R-CFA-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Canis familiaris)
RHEA:43410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP => sphinganine + UDP-alpha-D-galactose
GO:0019781	skos:prefLabel	"E1 NEDD8-activating enzyme"
GO:0019781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"E1 NEDD8-activating enzyme"
GO:0019781	skos:altLabel	"NEDD-activating enzyme E1"
GO:0019781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 activating enzyme activity
GO:0019781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUB1 activating enzyme activity
REACT:R-RNO-174690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Rattus norvegicus)
REACT:R-GGA-9691215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFR2 dimer (Gallus gallus)
RHEA:41248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate
RHEA:32098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)
REACT:R-RNO-9645428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 binds ADP-heptose (Rattus norvegicus)
REACT:R-CFA-8868230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
REACT:R-SPO-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Schizosaccharomyces pombe)
RHEA:54216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O
REACT:R-MMU-2426569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and IREM2 (Mus musculus)
REACT:R-SCE-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Saccharomyces cerevisiae)
RHEA:25140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) => 3-amino-2-oxopropyl phosphate + CO2
REACT:R-CFA-374337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apelin receptor binds to apelin (Canis familiaris)
RHEA:20250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine => D-alanine
REACT:R-DDI-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Dictyostelium discoideum)
REACT:R-GGA-8877902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated AR binds RUNX2 (Gallus gallus)
RHEA:49213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
RHEA:33201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + H(+) + NADH => butan-1-ol + NAD(+)
RHEA:36053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 beta-L-arabinofuranose => beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O
RHEA:56531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + D-tryptophan + FADH2 + O2 <=> 6-chloro-D-tryptophan + FAD + 2 H2O
GO:0050408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate kinase phosphatase activity
GO:0050408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity
GO:0050408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate kinase-phosphatase activity
GO:0050408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate kinase]-phosphatase activity
REACT:R-RNO-8987220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Rattus norvegicus)
GO:2001072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactomannan binding
RHEA:62045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)
REACT:R-BTA-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Bos taurus)
REACT:R-XTR-1474213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP1,8,9,13 (Xenopus tropicalis)
RHEA:15398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichloromethane + H2O => 2 chloride + formaldehyde + 2 H(+)
GO:0120091	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-oxoglutarate dioxygenase
GO:0120091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonic acid hydrolase
RHEA:21721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formamide => H2O + hydrogen cyanide
RHEA:55692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphoceramide + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)
REACT:R-MMU-349638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of SR-BI-bound spherical HDL (Mus musculus)
RHEA:48247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 <=> CMP + ganglioside GM1b + H(+)
RHEA:51330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2
REACT:R-BTA-9688831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK3 at K55, K363 (Bos taurus)
REACT:R-RNO-9707504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 oxidises ferrohemoglobin to MetHb (Rattus norvegicus)
REACT:R-HSA-9660538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
RHEA:60787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A24 + O2 <=> CO2 + gibberellin A25 + H(+) + succinate
REACT:R-GGA-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Gallus gallus)
RHEA:43775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-SSC-2730833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TEC kinases by p-SYK (Sus scrofa)
RHEA:48066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD1b (d18:1(4E)) + H2O
REACT:R-MMU-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)
REACT:R-MMU-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Mus musculus)
RHEA:66826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein]
REACT:R-SSC-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)
REACT:R-DME-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Drosophila melanogaster)
REACT:R-SSC-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Sus scrofa)
RHEA:65306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin T + CO2 + succinate => 2-oxoglutarate + O2 + verruculide A
RHEA:60816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A14 aldehyde + O2 = CO2 + gibberellin A14 + H(+) + succinate
REACT:R-DRE-6805507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 binds AVEN (Danio rerio)
REACT:R-SSC-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Sus scrofa)
RHEA:53691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
REACT:R-SSC-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Sus scrofa)
RHEA:37343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 2'-phosphate + H2O = adenosine + phosphate
RHEA:33796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sucrose => alpha-D-glucose + beta-D-fructose
REACT:R-SSC-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Sus scrofa)
RHEA:51124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine in snRNA = pseudouridine in snRNA
RHEA:55940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4-didehydroretinal + H(+) + NADH
REACT:R-MMU-877361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyrin binds ASC (Mus musculus)
RHEA:69841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-1264832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL7R (Homo sapiens)
REACT:R-BTA-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Bos taurus)
RHEA:28988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N-acetylneuraminate(in) => H(+)(out) + N-acetylneuraminate(out)
REACT:R-HSA-9668365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FVIIIa variant:FIXa does not convert FX to the active FXa (Homo sapiens)
RHEA:47621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethylhexyl sulfate + 2-oxoglutarate + O2 => 2-ethylhexanal + CO2 + H(+) + succinate + sulfate
REACT:R-RNO-2022073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen triple helix formation (Rattus norvegicus)
RHEA:65620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinga-(4E,8E)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine
REACT:R-GGA-9707594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind LY96 (Gallus gallus)
REACT:R-MMU-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Mus musculus)
RHEA:61845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solasodine + UDP-alpha-D-glucose => H(+) + solasodine 3-beta-D-glucoside + UDP
REACT:R-BTA-1306969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)
REACT:R-RNO-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Rattus norvegicus)
REACT:R-RNO-9653585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Farn-Me KRAS4B binds calmodulin (Rattus norvegicus)
RHEA:11578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + thiamine diphosphate => ATP + thiamine
RHEA:29378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O <=> adenosine + phosphate
REACT:R-MMU-8878220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the NOTCH1 coactivator complex (Mus musculus)
RHEA:51369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylglycine
REACT:R-GGA-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Gallus gallus)
RHEA:54654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O => peregrinol diphosphate
RHEA:47326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-3-phenylpropanoate + L-alanine => (S)-3-amino-3-phenylpropanoate + pyruvate
REACT:R-HSA-392152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble guanylate cyclase converts GTP to cGMP (Homo sapiens)
RHEA:57626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]
GO:1904678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoacyl-tRNA binding
GO:1904678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoacyl-tRNA binding
REACT:R-RNO-163843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-GAS6 to GAS6 (Rattus norvegicus)
RHEA:70762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-749454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gi complex dissociates (Bos taurus)
RHEA:40870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9E)-octadecadienoyl-CoA + FADH2
REACT:R-HSA-8983003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)
REACT:R-MMU-9678561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Mus musculus)
REACT:R-CEL-9647999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCE1 cleaves S-Farn proRAS proteins (Caenorhabditis elegans)
REACT:R-XTR-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)
RHEA:70102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + o-quinone methide + peniphenone D <=> penilactone A
RHEA:19444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + O2 <=> 3-hydroxy-cis,cis-muconate + 2 H(+)
GO:0022869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO:0022869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose PTS transporter activity
RHEA:25853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-183055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to EGFR (Danio rerio)
RHEA:31190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH
GO:0071209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U7 snRNA binding
REACT:R-HSA-1297275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD9:Izumo Binding (Homo sapiens)
REACT:R-RNO-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Rattus norvegicus)
GO:0051743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC reductase activity
GO:0051743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	red chlorophyll catabolite reductase activity
RHEA:34596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isopentadecanoyl-CoA + L-serine => 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA
REACT:R-RNO-5693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYM reduces P2C to PPCA (Rattus norvegicus)
RHEA:35963	skos:prefLabel	"fumitremorgin C synthase"
RHEA:35963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumitremorgin C synthase"
RHEA:35963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A = fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:34273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite => 2-nitroimidazole + H2O
GO:0035497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP-responsive element binding
GO:0035497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRE binding
GO:0035497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic AMP response element binding
GO:0035497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP response element binding
GO:0035497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-AMP-responsive element binding
GO:0035497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-AMP response element binding
REACT:R-SSC-8983834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Sus scrofa)
RHEA:28076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate + 3 H(+) + 2 NADH => (2R)-3-sulfopropanediol + H2O + 2 NAD(+)
REACT:R-RNO-183084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Rattus norvegicus)
REACT:R-RNO-4641246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 autoubiquitinates to promote its internalization (Rattus norvegicus)
REACT:R-RNO-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Rattus norvegicus)
RHEA:58927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol <=> (-)-maackiain + H2O
RHEA:12273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-dopa => CO2 + dopamine
RHEA:38128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol => 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA
GO:0102456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity
REACT:R-SCE-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Saccharomyces cerevisiae)
REACT:R-DRE-2395324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyrrole cross-links (Danio rerio)
RHEA:17432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + trans-4-hydroxycyclohexanecarboxylate <=> 4-oxocyclohexanecarboxylate + H(+) + NADH
RHEA:44316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)
REACT:R-SSC-9660192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR agonists bind VDR (Sus scrofa)
REACT:R-MMU-8863472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAB2 binds LRP2 (Mus musculus)
GO:0019174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydrothiophene 1-oxide reductase activity
REACT:R-XTR-5651773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds POLB at long-patch BER site (Xenopus tropicalis)
RHEA:42863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctanoyl-sn-glycerol + phosphate
GO:0140674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histone loader activity
GO:0140674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histone unloading activity
GO:0140674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histone loading activity
GO:0140674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleosome remodeling activity
GO:0140674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP-dependent histone loader activity
GO:0140674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP-dependent histone unloader activity
GO:0140674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histone unloader activity
GO:0140674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent histone chaperone activity
REACT:R-DME-5654655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PPTN11 (Drosophila melanogaster)
REACT:R-HSA-2161948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Homo sapiens)
REACT:R-BTA-204861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shc1 (Bos taurus)
REACT:R-DRE-1474266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibrils (Danio rerio)
RHEA:34843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromonapterin 3'-triphosphate + 3 H2O = 7,8-dihydromonapterin + 2 H(+) + 3 phosphate
RHEA:58763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)
REACT:R-BTA-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
RHEA:52406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-L-erythronate + H(+)
REACT:R-GGA-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Gallus gallus)
RHEA:24381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)
REACT:R-SSC-199112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRTAM binds to NECL2 (Sus scrofa)
REACT:R-HSA-5099899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD4 (Homo sapiens)
RHEA:49145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate
REACT:R-SCE-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Saccharomyces cerevisiae)
REACT:R-SPO-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)
RHEA:48079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde
REACT:R-XTR-426223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cation influx mediated by TRPC3/6/7 (Xenopus tropicalis)
RHEA:50649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O
REACT:R-MMU-174122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Mus musculus)
REACT:R-HSA-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Homo sapiens)
REACT:R-HSA-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Homo sapiens)
REACT:R-MMU-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
REACT:R-CFA-927832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
REACT:R-CFA-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Canis familiaris)
RHEA:39354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O
RHEA:64200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-leucine + H2O = a fatty acid + L-leucine
GO:0015445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	silver-exporting ATPase activity
GO:0015445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type Ag(+) transporter"
GO:0015445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type silver transporter activity
GO:0015445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ag+-exporting ATPase activity
GO:0015445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	silver transmembrane transporter activity, phosphorylative mechanism
GO:0015445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	silver exporting ATPase activity
GO:0015445	skos:prefLabel	"P-type Ag(+) transporter"
GO:0015445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP phosphohydrolase (Ag+-exporting)
GO:0015445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ag(+)(in) + ATP + H2O = ADP + Ag(+)(out) + H(+) + phosphate
RHEA:12061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O
REACT:R-XTR-8848873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARAP1 (Xenopus tropicalis)
RHEA:25694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranylfarnesyl diphosphate synthase"
RHEA:25694	skos:prefLabel	"geranylfarnesyl diphosphate synthase"
RHEA:25694	skos:altLabel	"FGPP synthase"
RHEA:25694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
REACT:R-BTA-2002440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen C-propeptides (Bos taurus)
REACT:R-SSC-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Sus scrofa)
REACT:R-HSA-6799777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)
REACT:R-SSC-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Sus scrofa)
REACT:R-CFA-4085133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUM (lumican) binds integrin alpha2beta1 (Canis familiaris)
RHEA:52763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O <=> (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate
REACT:R-BTA-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Bos taurus)
REACT:R-RNO-6809393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filaments bind cell-cell adhesion complexes (Rattus norvegicus)
RHEA:46460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:39723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol(in) = a 1,2-diacyl-sn-glycerol(out)
REACT:R-MMU-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Mus musculus)
REACT:R-HSA-9724753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds anti-fibrinolytics (Homo sapiens)
GO:0004089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbonate hydro-lyase (carbon-dioxide-forming)
GO:0004089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbonic dehydratase activity
GO:0004089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbonate anhydrase activity
GO:0004089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxyanhydrase activity
GO:0004089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbonic acid anhydrase activity
GO:0004089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonate dehydratase activity
GO:0004089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbonate hydro-lyase activity
GO:0004089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbonic anhydrase A
GO:0004089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anhydrase activity
GO:0004089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonic anhydrase activity
REACT:R-CEL-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Caenorhabditis elegans)
GO:0001854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C3d binding
REACT:R-MMU-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Mus musculus)
REACT:R-BTA-6809264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Bos taurus)
RHEA:39917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycerol + phosphate => 1-O-alkyl-sn-glycero-3-phosphate + H2O
RHEA:10458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-acetylmaltose + CoA => acetyl-CoA + D-maltose
RHEA:40782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminopentanenitrile + H(+) + 2 H2O <=> L-2-aminopentanoate + NH4(+)
REACT:R-CFA-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Canis familiaris)
RHEA:43571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADH
RHEA:61744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolbioside + UDP-alpha-D-glucose = stevioside + UDP
GO:0044589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pectin binding
RHEA:44274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA
REACT:R-BTA-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Bos taurus)
GO:0052738	skos:prefLabel	"With a quinone or similar compound as acceptor"
GO:0052738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor
GO:0052738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
RHEA:33380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyeicosasphinganine 1-phosphate + H2O => (4R)-hydroxyeicosasphinganine + phosphate
RHEA:27609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-DRE-265425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with von Willbrand Factor (Danio rerio)
REACT:R-RNO-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Rattus norvegicus)
REACT:R-SSC-8850797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK13 (Sus scrofa)
REACT:R-SSC-382061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular processing of novel PDGFs (Sus scrofa)
REACT:R-GGA-3323013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)
RHEA:38413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O
RHEA:25533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate => diphosphate + ent-cassa-12,15-diene
REACT:R-DRE-8854604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D16 accelerates GTP hydrolysis by RAB4A (Danio rerio)
GO:0140496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tubulin complex binding
RHEA:70061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-166387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The FA anion diffuses away laterally from UCP (Bos taurus)
REACT:R-HSA-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Homo sapiens)
REACT:R-SPO-175983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfer CH3 from AdoMet to 3,4DHBNZ (Schizosaccharomyces pombe)
RHEA:67558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycocholate
REACT:R-HSA-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Homo sapiens)
REACT:R-XTR-216756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Xenopus tropicalis)
REACT:R-RNO-416320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR1-containing  AMPA receptors (Rattus norvegicus)
RHEA:36212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate
REACT:R-SSC-1614460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of procollagen type VI (Sus scrofa)
RHEA:27778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) = 2-all-trans-octaprenylphenol + CO2
RHEA:53359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20b) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20b) in tRNA
REACT:R-SSC-1254248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80:YAP1 complex to the nucleus (Sus scrofa)
REACT:R-HSA-203613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylation of eNOS (Homo sapiens)
REACT:R-CFA-376123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM associates with Rac1-GTP:pPAK1 (Canis familiaris)
REACT:R-HSA-5668417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Homo sapiens)
REACT:R-MMU-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Mus musculus)
RHEA:67854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-N(5)-peroxide => FMNH2 + O2
REACT:R-MMU-2395818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)
REACT:R-SSC-9027272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Sus scrofa)
RHEA:40174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + O2 <=> (2E)-dodecenoyl-CoA + H2O2
REACT:R-SSC-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Sus scrofa)
REACT:R-DME-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-XTR-9753285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)
REACT:R-SSC-8851890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates SHC1-2 (Sus scrofa)
RHEA:50761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + sulfite => a quinol + sulfate
GO:0047953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
GO:0047953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyacetone reductase (NADPH)
GO:0047953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyacetone reductase activity
GO:0047953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 2-dehydrogenase (NADP+) activity
GO:0047953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol:NADP+ 2-oxidoreductase (glycerone-forming)
GO:0047953	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHA oxidoreductase activity
REACT:R-XTR-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Xenopus tropicalis)
RHEA:63137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione => cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione
REACT:R-DME-209336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated HOP is autophosphorylated and/or transphosphorylated (Drosophila melanogaster)
RHEA:16456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O <=> 2-formylbenzoate + pyruvate
REACT:R-DRE-193407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
RHEA:35067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine(out) = (S)-carnitine(in)
RHEA:68118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol
REACT:R-XTR-158218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Xenopus tropicalis)
RHEA:24457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ribazole 5'-phosphate + H2O => alpha-ribazole + phosphate
RHEA:52326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin] => 2 L-arginine + 4 O2 + 3 reduced [flavodoxin]
REACT:R-SSC-419646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:Met (Sus scrofa)
REACT:R-CFA-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Canis familiaris)
REACT:R-DME-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Drosophila melanogaster)
RHEA:40157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:17568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + S-adenosyl-L-methionine <=> 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9699163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective BARD1 does not bind BRCA1 (Homo sapiens)
RHEA:39795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxycholesterol(in) + ATP + H2O = 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate
RHEA:16286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-octopine + H2O + NAD(+) => H(+) + L-arginine + NADH + pyruvate
REACT:R-GGA-1251997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ERBB4m80 by gamma-scretase complex (Gallus gallus)
REACT:R-PFA-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Plasmodium falciparum)
GO:0047838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose dehydrogenase activity
GO:0047838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked D-xylose dehydrogenase activity
GO:0047838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-D-xylose
GO:0047838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(NAD)-linked D-xylose dehydrogenase activity
GO:0047838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose 1-dehydrogenase (NAD) activity
GO:0047838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-D-xylose dehydrogenase activity
GO:0047838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose:NAD+ 1-oxidoreductase activity
RHEA:11095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH
RHEA:29578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine(in) + Na(+)(in) <=> L-serine(out) + Na(+)(out)
REACT:R-HSA-372505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylcholine synaptic vesicle docking and priming (Homo sapiens)
RHEA:37814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:62046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O
GO:0052810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol 5-kinase activity
GO:0052810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:1-phosphatidyl-1D-myo-inositol 5-phosphotransferase activity
GO:0052810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol-5-kinase activity
GO:0052810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)
RHEA:34531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)
RHEA:34531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase"
RHEA:34531	skos:prefLabel	"dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase"
REACT:R-CFA-349638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of SR-BI-bound spherical HDL (Canis familiaris)
RHEA:32708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (2R,4S)-bornyl diphosphate
GO:0009020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (guanosine-2'-O-)-methyltransferase activity
GO:0009020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate guanosine 2'-methyltransferase activity
GO:0009020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA guanosine-2'-O-methyltransferase activity
GO:0009020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA (Gm18) 2'-O-methyltransferase activity
GO:0009020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity
GO:0009020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity
GO:0009020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA guanosine 2'-methyltransferase activity
GO:0009020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA (Gm18) methyltransferase activity
GO:0009020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA (guanosine 2')-methyltransferase activity
RHEA:61641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isophthalyl-CoA => benzoyl-CoA + CO2
REACT:R-SSC-5358336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB forms mixed disulphides with Hh precursors (Sus scrofa)
RHEA:44511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-MMU-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Mus musculus)
RHEA:41729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0043959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HpcH/HpaI aldolase
GO:0043959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythro-3-methylmalyl-CoA lyase activity
REACT:R-RNO-6804402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F1 (Rattus norvegicus)
REACT:R-BTA-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Bos taurus)
RHEA:28740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(in) + H(+)(out) => Cd(2+)(out) + H(+)(in)
REACT:R-XTR-751019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:G12/13 complex dissociates (Xenopus tropicalis)
REACT:R-XTR-5661125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2sR4-HIST1H4 (Xenopus tropicalis)
GO:0033459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic acid tRNA
GO:0033459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAA codon-amino acid adaptor activity
REACT:R-XTR-158313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XII -> factor XIIa (Xenopus tropicalis)
REACT:R-RNO-9714477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)
REACT:R-CFA-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Canis familiaris)
RHEA:13105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 2-phosphate + H2O = glycerol + phosphate
RHEA:13105	skos:prefLabel	"glycerol-2-phosphatase"
RHEA:13105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-2-phosphatase"
RHEA:57996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh2 + H(+) + UDP
RHEA:24007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-SSC-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Sus scrofa)
GO:0098770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXO family protein binding
REACT:R-RNO-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Rattus norvegicus)
RHEA:72804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + N(omega)-methyl-L-arginine(in) => L-arginine(in) + N(omega)-methyl-L-arginine(out)
RHEA:36586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-fucose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH
REACT:R-XTR-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Xenopus tropicalis)
RHEA:25860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)
RHEA:25860	skos:prefLabel	"GTP cyclohydrolase IV"
RHEA:25860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GTP cyclohydrolase IV"
RHEA:53757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholoyl-CoA + cholate => allodeoxycholate + choloyl-CoA
REACT:R-BTA-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Bos taurus)
GO:0008867	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactarate hydro-lyase activity
GO:0008867	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)
GO:0008867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate dehydratase activity
REACT:R-XTR-173709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C7 binds C5b:C6 (Xenopus tropicalis)
REACT:R-DRE-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
REACT:R-SCE-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Saccharomyces cerevisiae)
RHEA:45275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-phosphooxy-(9Z)-octadecenoate + H2O <=> 12-hydroxy-(9Z)-octadecenoate + phosphate
RHEA:46479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:30274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (3,4-dimethoxyphenyl)methanol + H2O2 <=> 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O
REACT:R-DME-350486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSH binds to FZ at the plasma membrane (Drosophila melanogaster)
RHEA:38966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + leukotriene C4(in) <=> ADP + H(+) + leukotriene C4(out) + phosphate
RHEA:45945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DRE-8959510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)
EC:2.3.1.283	skos:prefLabel	"2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase"
EC:2.3.1.283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase"
RHEA:57526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+) => a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O
RHEA:35645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H(+) + NADH => a (2R)-2-hydroxycarboxylate + NAD(+)
REACT:R-GGA-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Gallus gallus)
RHEA:38085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol
REACT:R-MMU-6782004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the pre-incision complex in TC-NER (Mus musculus)
GO:0004576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharyl transferase activity
GO:0004576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharide transferase activity
RHEA:41122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine
RHEA:43127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(10) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine
REACT:R-CFA-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Canis familiaris)
RHEA:16981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate + NADP(+) = H(+) + maleylacetate + NADPH
RHEA:16981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate + NAD(+) = H(+) + maleylacetate + NADH
RHEA:16981	skos:prefLabel	"maleylacetate reductase"
RHEA:16981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maleylacetate reductase"
RHEA:16981	skos:altLabel	"maleolylacetate reductase"
RHEA:68733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-8942607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Bos taurus)
REACT:R-BTA-443978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR11 binds CCL19, CCL21 & CCL25 (Bos taurus)
REACT:R-DME-975122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Drosophila melanogaster)
GO:0042292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	URM1 activating enzyme activity
REACT:R-DDI-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Dictyostelium discoideum)
REACT:R-DME-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Drosophila melanogaster)
RHEA:46071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-nonenoyl-CoA <=> (2E)-nonenoyl-CoA
GO:0102892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betanidin 5-O-glucosyltransferase activity
REACT:R-HSA-3656269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG (Homo sapiens)
RHEA:72477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate(out) + citrate(in) => cis-aconitate(in) + citrate(out)
REACT:R-SSC-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Sus scrofa)
REACT:R-BTA-8848818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CBL (Bos taurus)
REACT:R-CFA-201629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Tau (Canis familiaris)
RHEA:52598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocholan-24-oyl-CoA + H(+) + NADH => lithocholoyl-CoA + NAD(+)
REACT:R-SSC-432195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Sus scrofa)
GO:0022882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucoside PTS transporter activity
GO:0022882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity
REACT:R-HSA-1222526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AhpC reduces peroxidated lipids (Homo sapiens)
RHEA:39994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine
REACT:R-HSA-2197698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src phosphorylate WASP,N-WASP (Homo sapiens)
REACT:R-RNO-379415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Rattus norvegicus)
REACT:R-RNO-9014296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GEFs activate RAC2 (Rattus norvegicus)
REACT:R-MMU-421836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Vesicle Uncoating (Mus musculus)
REACT:R-CFA-5654224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds PLCG1 (Canis familiaris)
REACT:R-XTR-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Xenopus tropicalis)
RHEA:43323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin <=> a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
REACT:R-CFA-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Canis familiaris)
RHEA:51708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-altritol + NAD(+) = H(+) + keto-D-tagatose + NADH
RHEA:51708	skos:prefLabel	"D-altritol 5-dehydrogenase"
RHEA:51708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-altritol 5-dehydrogenase"
GO:0046525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylosylprotein 4-beta-galactosyltransferase activity
GO:0046525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose:xylose galactosyltransferase activity
GO:0046525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity
GO:0046525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-galactose:D-xylose galactosyltransferase activity
GO:0046525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
GO:0046525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-xylose galactosyltransferase activity
GO:0046525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosyltransferase I activity
GO:0046525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity
GO:0046525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-galactose:xylose galactosyltransferase activity
GO:0019180	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity
GO:0019180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-amino-4,6-dideoxygalactose transaminase activity
GO:0019180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-fucosamine aminotransferase activity
GO:0019180	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphosphoaminodideoxygalactose aminotransferase activity
GO:0019180	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity
GO:0019180	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity
RHEA:21868	skos:prefLabel	"diaminohydroxyphosphoribosylaminopyrimidine deaminase"
RHEA:21868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diaminohydroxyphosphoribosylaminopyrimidine deaminase"
RHEA:21868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)
REACT:R-MMU-3247493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO1 (Mus musculus)
REACT:R-CFA-9014454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG translocates to the ER membrane (Canis familiaris)
REACT:R-SSC-174255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation multiubiquitinated Cyclin A (Sus scrofa)
REACT:R-SSC-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Sus scrofa)
REACT:R-DRE-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Danio rerio)
RHEA:48668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:17878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a catechol + S-adenosyl-L-methionine => a guaiacol + H(+) + S-adenosyl-L-homocysteine
RHEA:32978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine
RHEA:52715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + thymine
REACT:R-HSA-2993790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO2 from E1 to UBE2I (UBC9) (Homo sapiens)
REACT:R-CFA-8853789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDNF,NRTN bind RET:GFRA1,GFRA2 (Canis familiaris)
REACT:R-BTA-373747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of nephrin by FYN (Bos taurus)
REACT:R-DRE-8942099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Danio rerio)
RHEA:28645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-zingiberene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-HSA-2465890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR2 binds collagen type I, II, III, V, X fibrils (Homo sapiens)
REACT:R-SSC-2203480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC11 binds ligands (Sus scrofa)
RHEA:15203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxymellein + H(+) + S-adenosyl-L-homocysteine => 6-hydroxymellein + S-adenosyl-L-methionine
RHEA:50925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
RHEA:50305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-451757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of nephrin and KIRREL2, KIRREL3 (Caenorhabditis elegans)
GO:0050269	skos:prefLabel	"coniferyl-aldehyde dehydrogenase"
GO:0050269	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coniferyl aldehyde:NAD(P)+ oxidoreductase activity
GO:0050269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coniferyl-aldehyde dehydrogenase"
GO:0050269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + H2O + NAD(+) = (E)-ferulate + 2 H(+) + NADH
GO:0050269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coniferyl-aldehyde dehydrogenase activity
GO:0050269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + H2O + NADP(+) = (E)-ferulate + 2 H(+) + NADPH
REACT:R-MMU-2730884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of NTAL by p-SYK/Lyn (Mus musculus)
GO:0032142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single guanine insertion binding
RHEA:14723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-beta-D-xylosylzeatin + UDP => UDP-alpha-D-xylose + zeatin
REACT:R-BTA-3321805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSL acetylates histone H4 (Bos taurus)
RHEA:47483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + NADP(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
RHEA:67352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + rhaponticin = 6-O-malonyl-rhaponticin + CoA
RHEA:19091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + precorrin-1 + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uroporphyrinogen III
REACT:R-HSA-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Homo sapiens)
RHEA:38636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-DME-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Drosophila melanogaster)
RHEA:11628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H(+) = an aldehyde + CO2
GO:0016635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
GO:0016635	skos:prefLabel	"With a quinone or related compound as acceptor"
GO:0016635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or related compound as acceptor"
REACT:R-BTA-4641249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Bos taurus)
RHEA:28962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose(in) + H(+)(in) <=> D-xylose(out) + H(+)(out)
RHEA:53011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate <=> di-trans,poly-cis-polyprenyl diphosphate + n diphosphate
REACT:R-DRE-909721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ISGF3 complex to nucleus (Danio rerio)
REACT:R-CFA-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Canis familiaris)
RHEA:49173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine
GO:0050459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethanolamine-phosphate phospho-lyase (deaminating)
GO:0050459	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	amino alcohol O-phosphate phospholyase activity
GO:0050459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-phosphorylethanol-amine phospho-lyase activity
GO:0050459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-phosphoethanolamine-phospholyase activity
GO:0050459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)
GO:0050459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine-phosphate phospho-lyase activity
RHEA:61112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA
RHEA:67995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + trichloroethene <=> (Z)-1,2-dichloroethene + A + chloride + H(+)
RHEA:33065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 oxidized [2Fe-2S]-[putidaredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin]
RHEA:29873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + thiosulfate(in) => ATP + H2O + thiosulfate(out)
REACT:R-CFA-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Canis familiaris)
RHEA:63117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxynitrite => nitrate
RHEA:22579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-homoserine lactone + H2O <=> an N-acyl-L-homoserine + H(+)
REACT:R-RNO-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Rattus norvegicus)
REACT:R-SPO-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Schizosaccharomyces pombe)
REACT:R-HSA-1168374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)
REACT:R-MMU-374701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DCC by Fyn (Mus musculus)
REACT:R-SSC-975389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Sus scrofa)
RHEA:41112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate
REACT:R-DME-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Drosophila melanogaster)
RHEA:65991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	previtamin D3 <=> calciol
REACT:R-RNO-187934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Rattus norvegicus)
REACT:R-GGA-202248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma1 (Gallus gallus)
REACT:R-BTA-9005980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 binds IL21R:JAK1 (Bos taurus)
REACT:R-RNO-381446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)
RHEA:32169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aerobactin + AMP + diphosphate + H(+) => ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine
RHEA:70688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) => 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)
RHEA:67930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phosphouridine-RNA + H(+) => a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O
REACT:R-SSC-913371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF receptor alpha:GM-CSF binds Bc (Sus scrofa)
GO:0140062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5fC dioxygenase
GO:0140062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formylcytosine dioxygenase activity
REACT:R-CFA-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Canis familiaris)
RHEA:28001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine diphosphate <=> H(+) + phosphate + thiamine phosphate
GO:0047235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose 6F-alpha-galactotransferase activity
GO:0047235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose 6(F)-alpha-galactosyltransferase activity
GO:0047235	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity
GO:0047235	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity
GO:0047235	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity
GO:0047235	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose 6F-alpha-galactosyltransferase activity
GO:0047235	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity
REACT:R-SSC-110350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of TDG glycosylase by APEX1 at the AP site (Sus scrofa)
REACT:R-CEL-879562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Caenorhabditis elegans)
RHEA:15014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha(S)-strictosidine + H2O => secologanin + tryptamine
RHEA:46475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:66172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-cystine(out) = H(+)(in) + L-cystine(in)
REACT:R-XTR-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Xenopus tropicalis)
REACT:R-BTA-388829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 phosphatase binds CTLA-4 (Bos taurus)
REACT:R-HSA-442739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates RSKs (Homo sapiens)
REACT:R-DME-5694077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Drosophila melanogaster)
GO:0050202	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]
GO:0050202	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	octopamine hydro-lyase (deaminating)
GO:0050202	skos:prefLabel	"octopamine dehydratase"
GO:0050202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"octopamine dehydratase"
GO:0050202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octopamine dehydratase activity
GO:0050202	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	octopamine hydrolyase activity
GO:0050202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-octopamine = (4-hydroxyphenyl)acetaldehyde + NH4(+)
RHEA:59501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate
RHEA:39930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-HSA-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Homo sapiens)
REACT:R-RNO-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Rattus norvegicus)
RHEA:39513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA
REACT:R-HSA-9752950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Olfactory Receptor (Homo sapiens)
RHEA:69699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O = beta-D-glucose + N-hexadecanoylsphing-4-enine
RHEA:13008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine <=> H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine
REACT:R-SSC-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Sus scrofa)
RHEA:72331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
REACT:R-CFA-3165230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC52A1,2,3 transport RIB from extracellular region to cytosol (Canis familiaris)
RHEA:36349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine => N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine
RHEA:72842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + CoA(in) <=> ADP(in) + CoA(out)
RHEA:30772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + H2O => D-ribose + guanine
RHEA:68513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => alpha-acoradiene + diphosphate
REACT:R-CEL-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Caenorhabditis elegans)
REACT:R-CFA-111966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 binds CALM1:4Ca2+ (Canis familiaris)
REACT:R-DME-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Drosophila melanogaster)
RHEA:11780	skos:altLabel	"galactosyltransferase II"
RHEA:11780	skos:altLabel	"uridine diphosphogalactose-galactosylxylose galactosyltransferase"
RHEA:11780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP
RHEA:11780	skos:prefLabel	"galactosylxylosylprotein 3-beta-galactosyltransferase"
RHEA:11780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactosylxylosylprotein 3-beta-galactosyltransferase"
REACT:R-XTR-6786171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 deubiquitination by USP1:WDR48 (Xenopus tropicalis)
REACT:R-SCE-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Saccharomyces cerevisiae)
RHEA:63365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2
REACT:R-HSA-6805640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates KAT6A (Homo sapiens)
RHEA:19089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-1 + S-adenosyl-L-homocysteine
REACT:R-CEL-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Caenorhabditis elegans)
REACT:R-CFA-9670101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATRX:DAXX binds to subtelomeric chromosomal regions (Canis familiaris)
REACT:R-DDI-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Dictyostelium discoideum)
REACT:R-DRE-173483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAMBI interferes with the interaction of type I receptor with type II receptor (Danio rerio)
RHEA:18472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + L-glutamine <=> an N(2)-acyl-L-glutamine + CoA + H(+)
RHEA:59447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A <=> 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2
EC:3.2.1.136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronoarabinoxylan endo-1,4-beta-xylanase"
EC:3.2.1.136	skos:altLabel	"feraxan endoxylanase"
EC:3.2.1.136	skos:prefLabel	"glucuronoarabinoxylan endo-1,4-beta-xylanase"
GO:0005146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukemia inhibitory factor receptor binding
GO:0005146	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leukemia inhibitory factor receptor ligand
GO:0005146	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leukemia inhibitory factor
EC:4.2.1.170	skos:prefLabel	"2-(omega-methylthio)alkylmalate dehydratase"
EC:4.2.1.170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-(omega-methylthio)alkylmalate dehydratase"
REACT:R-HSA-1602458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP10 (Homo sapiens)
REACT:R-HSA-9624624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXO32 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)
REACT:R-DRE-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Danio rerio)
REACT:R-SSC-114684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Syntaxin-4 (Sus scrofa)
REACT:R-HSA-6811539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reinforcement of the Cornified Envelope (Homo sapiens)
REACT:R-PFA-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)
RHEA:49012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADH + O2 = aurachin C epoxide + H2O + NAD(+)
RHEA:37118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-sphing-4-enine
GO:0001730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-5')oligo(A) synthetase activity
GO:0001730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-5'-oligoadenylate synthetase activity
GO:0001730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-5A synthetase activity
GO:0001730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-5' oligoadenylate synthetase activity
GO:0001730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligo-2',5'-adenylate synthetase activity
REACT:R-BTA-8944216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XV (Bos taurus)
REACT:R-MMU-8874979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD3 binds GOLGB1 (Mus musculus)
REACT:R-GGA-8953037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F8 forms homodimers (Gallus gallus)
REACT:R-HSA-3595178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CHSY1 does not transfer GlcA to chondroitin (Homo sapiens)
RHEA:14323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + morphinone + NADPH => morphine + NADP(+)
RHEA:18723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ent-13-epi-manoyl oxide => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate
REACT:R-XTR-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Xenopus tropicalis)
REACT:R-DME-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Drosophila melanogaster)
REACT:R-HSA-391940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 and EP4 receptors can bind PGE2 (Homo sapiens)
RHEA:34278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine <=> 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine
RHEA:35243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + thiamine diphosphate = adenosine thiamine triphosphate + phosphate
RHEA:62513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + melatonin + O2 => 2-hydroxymelatonin + CO2 + succinate
RHEA:59677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraose + O2 => D-maltotetraono-1,5-lactone + H2O2
REACT:R-HSA-9701003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 heterodimer (Homo sapiens)
REACT:R-RNO-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Rattus norvegicus)
REACT:R-DDI-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Dictyostelium discoideum)
REACT:R-CFA-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
REACT:R-DRE-174157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cyclin B (Danio rerio)
REACT:R-SSC-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Sus scrofa)
RHEA:40371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase"
RHEA:40371	skos:prefLabel	"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase"
RHEA:40371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP = 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)
RHEA:37434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine
REACT:R-SSC-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Sus scrofa)
REACT:R-XTR-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)
RHEA:44019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) <=> 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH
RHEA:53121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH
REACT:R-HSA-2855077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-3 binds to molecular patterns on the target cell surface  (Homo sapiens)
RHEA:14631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + N-acetyl-L-glutamyl 5-phosphate => ATP + N-acetyl-L-glutamate
REACT:R-SPO-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Schizosaccharomyces pombe)
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-ribosyluracil 5-phosphate synthetase activity
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine monophosphate synthase activity
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	psiUMP synthetase activity
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridylate synthase activity
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pseudouridylate synthetase activity
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine-5'-phosphate glycosidase activity
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pseudouridylic acid synthetase activity
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uracil hydro-lyase (adding D-ribose 5-phosphate)
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pseudouridine monophosphate synthetase activity
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)
GO:0004730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uracil hydrolyase activity
RHEA:55474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-8950213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Phosphatidylinositol transfer protein alpha isoform (Homo sapiens)
RHEA:54287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-octadecanoylsphing-4-enine + phosphocholine
RHEA:17350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate
RHEA:61399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]
RHEA:49500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)
RHEA:49392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
REACT:R-HSA-350168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Homo sapiens)
REACT:R-XTR-6797627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPG hydrolyses L-Asn to L-Asp (Xenopus tropicalis)
RHEA:53714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hematin => 2 Fe(III)-heme b
REACT:R-DRE-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Danio rerio)
REACT:R-DRE-163809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)
RHEA:70924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline(out) + chloride(out) + Na(+)(out) => (R)-noradrenaline(in) + chloride(in) + Na(+)(in)
RHEA:25144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + H2O => 3-hydroxyanthranilate + H(+) + L-alanine
REACT:R-HSA-9006873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT binding (Homo sapiens)
REACT:R-HSA-8869627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NR to yield NMN (Homo sapiens)
REACT:R-GGA-8847638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Gallus gallus)
REACT:R-MMU-913374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits SHIP (Mus musculus)
REACT:R-SSC-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Sus scrofa)
RHEA:58570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-acetyl-15alpha-stemmadenine => 15alpha-stemmadenine + acetyl-CoA
REACT:R-CFA-5624486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylates RAF1 on Y340,Y341 (Canis familiaris)
REACT:R-MMU-69144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 (Mus musculus)
RHEA:44297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA => 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA
RHEA:70640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-DRE-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Danio rerio)
REACT:R-MMU-879914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3 stimulation induces Vav binding to Tec kinase (Mus musculus)
RHEA:30672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiose => 2 N-acetyl-D-glucosamine
REACT:R-HSA-9645126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activators bind STAT5 (Homo sapiens)
REACT:R-BTA-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Bos taurus)
REACT:R-BTA-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
REACT:R-HSA-8851988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A2 binds T cell surface (Homo sapiens)
RHEA:48260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1 = CMP + ganglioside GD1a + H(+)
REACT:R-XTR-1614336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Xenopus tropicalis)
RHEA:12674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic amide => a nitrile + H2O
REACT:R-XTR-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Xenopus tropicalis)
RHEA:21686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + H(+) + NADH + pyruvate => (R)-beta-alanopine + H2O + NAD(+)
REACT:R-DRE-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Danio rerio)
REACT:R-SSC-6805573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I/type II heterodimers form tetramers (Sus scrofa)
REACT:R-XTR-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)
REACT:R-XTR-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Xenopus tropicalis)
REACT:R-HSA-375151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with collagens (Homo sapiens)
REACT:R-CEL-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Caenorhabditis elegans)
RHEA:59381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxyprephenate + NAD(+) => 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH
REACT:R-XTR-9750016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Xenopus tropicalis)
RHEA:42306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O
RHEA:63717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	losartan + UDP-alpha-D-glucuronate => losartan-1-N-beta-D-glucuronide + UDP
RHEA:50408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4(1H)-quinolone + H2O
REACT:R-HSA-9707827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike binds Spike inhibitors (Homo sapiens)
REACT:R-XTR-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Xenopus tropicalis)
REACT:R-BTA-446870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated TRAF6 binds the TAK1 complex (Bos taurus)
REACT:R-BTA-9018858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Bos taurus)
GO:0050318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tannin acylhydrolase activity
GO:0050318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tannase S
GO:0050318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tannin acetylhydrolase activity
GO:0050318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tannase activity
RHEA:69987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) = (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH
REACT:R-DRE-5340226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB dioxygenates NO (Danio rerio)
RHEA:65798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DME-4615839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO2,3 (Drosophila melanogaster)
REACT:R-DRE-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Danio rerio)
RHEA:33039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:15206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphooligosaccharide + H2O => a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)
REACT:R-XTR-8952039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Xenopus tropicalis)
REACT:R-DME-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Drosophila melanogaster)
REACT:R-DRE-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Danio rerio)
REACT:R-HSA-9756180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)
RHEA:19476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + H2O + NAD(+)
RHEA:54983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)
REACT:R-XTR-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Xenopus tropicalis)
RHEA:59041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
GO:0050422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	strictosidine b-glucosidase activity
GO:0050422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	strictosidine beta-glucosidase activity
GO:0050422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	strictosidine beta-D-glucohydrolase activity
REACT:R-CFA-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Canis familiaris)
RHEA:18885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
RHEA:18885	skos:altLabel	"GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase"
RHEA:18885	skos:altLabel	"GDP-fucose synthetase"
RHEA:18885	skos:prefLabel	"GDP-L-fucose synthase"
RHEA:18885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-L-fucose synthase"
REACT:R-DME-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Drosophila melanogaster)
REACT:R-RNO-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Rattus norvegicus)
REACT:R-SSC-2731141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds fibronectin (Sus scrofa)
RHEA:60331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine
REACT:R-BTA-5263614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)
RHEA:60395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O <=> Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)
RHEA:16460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH
REACT:R-CFA-5577237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNH2:KCNE transport K+ from cytosol to extracellular region (Canis familiaris)
REACT:R-XTR-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Xenopus tropicalis)
RHEA:14459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-propylmalate + CoA + H(+) => glyoxylate + H2O + pentanoyl-CoA
RHEA:39659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
RHEA:47696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate
REACT:R-DRE-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Danio rerio)
REACT:R-HSA-1971482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Homo sapiens)
GO:0045513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-27 binding
GO:0045513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-27 binding
REACT:R-CFA-4420143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SH2D2A (Canis familiaris)
REACT:R-DRE-4084999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU1 hydrolyses Neu5Ac from glycoconjugates (Danio rerio)
REACT:R-SSC-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Sus scrofa)
REACT:R-GGA-2730903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of TRAF6 (Gallus gallus)
REACT:R-GGA-1592297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full activation of MMP1 (Gallus gallus)
REACT:R-XTR-6810357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fillagrin and keratin intermediate filaments polymerise forming a network (Xenopus tropicalis)
REACT:R-CEL-5423038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Caenorhabditis elegans)
RHEA:29125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O(out) + nitrite(out) + ubiquinone-8(in) => nitrate(out) + ubiquinol-8(in)
REACT:R-SSC-140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Sus scrofa)
REACT:R-RNO-8948222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)
REACT:R-DME-449077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-16 is secreted (Drosophila melanogaster)
RHEA:50296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] = 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-193455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)
REACT:R-MMU-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Mus musculus)
REACT:R-HSA-2430535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL phosphorylates ENSA (Homo sapiens)
REACT:R-CEL-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Caenorhabditis elegans)
RHEA:13562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)
REACT:R-HSA-3000434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Homo sapiens)
RHEA:50349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
REACT:R-SSC-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Sus scrofa)
REACT:R-SSC-380574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine synaptic vesicle docking and priming (Sus scrofa)
REACT:R-SSC-8854302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D7 binds the TSC1-TSC2 complex (Sus scrofa)
RHEA:30660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(phosphooxy)-L-threonine + H2O => 4-hydroxy-L-threonine + phosphate
REACT:R-DRE-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Danio rerio)
REACT:R-CFA-199014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD96 binds PVR (Canis familiaris)
REACT:R-SSC-389639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Sus scrofa)
REACT:R-BTA-6805755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 dimethylates TP53 (Bos taurus)
RHEA:56297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] => pyruvate + S-sulfanyl-L-cysteinyl-[protein]
RHEA:34003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 = 7-dehydrodesmosterol + 2 H2O + NADP(+)
REACT:R-HSA-9620723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VGF gene expression (Homo sapiens)
REACT:R-SSC-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Sus scrofa)
RHEA:46550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine => a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:0050539	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	imidase activity
GO:0050539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic imide hydrolase activity
GO:0050539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleimide hydrolase activity
GO:0050539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic-imide amidohydrolase (decyclizing)
GO:0050539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic-imide amidohydrolase (decyclicizing)
REACT:R-HSA-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Homo sapiens)
REACT:R-HSA-8944263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type II (Homo sapiens)
GO:0046571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-2-keto-4-methylthiobutyrate transaminase activity
RHEA:11129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA => 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA
REACT:R-DRE-606289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	New CENPA-containing nucleosomes are deposited at the centromere (Danio rerio)
REACT:R-PFA-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Plasmodium falciparum)
RHEA:12965	skos:prefLabel	"galacturonokinase"
RHEA:12965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galacturonokinase"
RHEA:12965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-galacturonate = 1-phospho-alpha-D-galacturonate + ADP + H(+)
RHEA:27639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + xanthosine => alpha-D-ribose 1-phosphate + xanthine
RHEA:12158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+)
REACT:R-SSC-5684169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6B binds PTPN6,PTPN11 (Sus scrofa)
REACT:R-MMU-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Mus musculus)
RHEA:46186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + AMP + diphosphate => ATP + CoA + isovalerate
REACT:R-DME-549129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations into hepatic cells (Drosophila melanogaster)
REACT:R-DME-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Drosophila melanogaster)
REACT:R-GGA-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Gallus gallus)
REACT:R-SSC-143468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEOS oxidizes ethanol to acetaldehyde (Sus scrofa)
REACT:R-RNO-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Rattus norvegicus)
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialyltransferase 3C activity
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ST6GALNAC activity
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialyltransferase 7D activity
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase activity
GO:0047290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SIAT7
RHEA:68792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide
RHEA:51637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + selenite => a quinol + selenate
REACT:R-XTR-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Xenopus tropicalis)
REACT:R-CFA-204169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP dephosphorylates p-lipo-PDH (Canis familiaris)
REACT:R-GGA-112342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of MAP2K1 by CDK1 (Gallus gallus)
GO:0004099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitin deacetylase activity
GO:0004099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitin amidohydrolase activity
RHEA:68044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-RNO-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Rattus norvegicus)
GO:0106250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-binding transcription repressor activity, RNA polymerase III-specific
REACT:R-DRE-975389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Danio rerio)
RHEA:50846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate
EC:1.1.1.86	skos:altLabel	"alpha-keto-beta-hydroxylacyl reductoisomerase"
EC:1.1.1.86	skos:prefLabel	"ketol-acid reductoisomerase (NADP(+))"
EC:1.1.1.86	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ketol-acid reductoisomerase (NADP(+))"
EC:1.1.1.86	skos:altLabel	"acetohydroxy acid isomeroreductase"
EC:1.1.1.86	skos:altLabel	"dihydroxyisovalerate dehydrogenase (isomerizing)"
REACT:R-HSA-9032601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN-mediated phosphorylation of GRIN2B (Homo sapiens)
REACT:R-BTA-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Bos taurus)
RHEA:46957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
REACT:R-MMU-420883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins act as GEFs for G alpha-t (Mus musculus)
REACT:R-XTR-1605768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Xenopus tropicalis)
RHEA:34941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + selenate => H2O + menaquinone-8 + selenite
RHEA:71106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) + S-methylmercury-L-cysteine(out) <=> L-methionine(out) + S-methylmercury-L-cysteine(in)
REACT:R-SSC-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Sus scrofa)
RHEA:28798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH
RHEA:20257	skos:prefLabel	"3-methyleneoxindole reductase"
RHEA:20257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-methyleneoxindole reductase"
RHEA:20257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH
REACT:R-CFA-168400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iE-DAP elicits a NOD1 response (Canis familiaris)
GO:0047698	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-alanyl coenzyme A ammonia-lyase activity
GO:0047698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-CoA = acryloyl-CoA + NH4(+)
GO:0047698	skos:prefLabel	"beta-alanyl-CoA ammonia-lyase"
GO:0047698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	b-alanyl-CoA ammonia-lyase activity
GO:0047698	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)
GO:0047698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-CoA ammonia-lyase activity
GO:0047698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-alanyl-CoA ammonia-lyase"
RHEA:58902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + urea-1,3-dicarboxylate => 1-carboxybiuret + H2O
REACT:R-HSA-6781814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 deubiquitinates RNF123 (Homo sapiens)
REACT:R-CEL-3159259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAA:MUT binds AdoCbl (Caenorhabditis elegans)
REACT:R-RNO-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Rattus norvegicus)
GO:0015097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mercury ion transmembrane transporter activity
GO:0015097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hg(2+)(in) = Hg(2+)(out)
REACT:R-CFA-158982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Canis familiaris)
REACT:R-MMU-69140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap (Mus musculus)
EC:4.2.2.17	skos:altLabel	"inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride)"
EC:4.2.2.17	skos:altLabel	"inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming)"
EC:4.2.2.17	skos:prefLabel	"inulin fructotransferase (DFA-I-forming)"
EC:4.2.2.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inulin fructotransferase (DFA-I-forming)"
EC:4.2.2.17	skos:altLabel	"inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming)"
EC:4.2.2.17	skos:altLabel	"inulin fructotransferase (DFA-I-producing)"
RHEA:17021	skos:altLabel	"2-aminoethylphosphonate--pyruvate aminotransferase"
RHEA:17021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde
RHEA:17021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-aminoethylphosphonate--pyruvate transaminase"
RHEA:17021	skos:altLabel	"(2-aminoethyl)phosphonate--pyruvate aminotransferase"
RHEA:17021	skos:altLabel	"2-aminoethylphosphonate aminotransferase"
RHEA:17021	skos:altLabel	"(2-aminoethyl)phosphonic acid aminotransferase"
RHEA:17021	skos:altLabel	"(2-aminoethyl)phosphonate transaminase"
RHEA:17021	skos:prefLabel	"2-aminoethylphosphonate--pyruvate transaminase"
REACT:R-MMU-216069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaDbeta2 with fibrin (Mus musculus)
REACT:R-XTR-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Xenopus tropicalis)
REACT:R-MMU-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Mus musculus)
REACT:R-BTA-913424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
RHEA:24873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-D-serine = D-serine + phosphate
REACT:R-BTA-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Bos taurus)
REACT:R-SSC-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Sus scrofa)
REACT:R-DDI-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Dictyostelium discoideum)
REACT:R-MMU-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Mus musculus)
RHEA:16115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH => 2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+)
REACT:R-MMU-5607737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 oligomerizes (Mus musculus)
RHEA:72747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene E4(out) = leukotriene E4(in)
RHEA:18402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Drosophila melanogaster)
RHEA:35402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine <=> beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)
RHEA:56846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocamycin I + S-adenosyl-L-homocysteine => nocamycin E + S-adenosyl-L-methionine
REACT:R-DRE-8961021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD binds with itself to form SFTPD 12mer (Danio rerio)
REACT:R-SSC-1112690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds CBL (Sus scrofa)
RHEA:40144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H2O => (9Z,12Z)-octadecadienoate + CoA + H(+)
RHEA:35646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH
RHEA:23863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + deacetylcephalosporin C <=> cephalosporin C + CoA
REACT:R-HSA-914036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)
REACT:R-RNO-430073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Rattus norvegicus)
RHEA:70189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose => alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose
RHEA:37297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-alanyl-L-threonine(in) + phosphate => ATP + H2O + L-alanyl-L-threonine(out)
REACT:R-GGA-426489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC binds inexactly matching target RNAs (Gallus gallus)
REACT:R-CFA-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Canis familiaris)
RHEA:31720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8951486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C4b (Homo sapiens)
REACT:R-BTA-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Bos taurus)
REACT:R-SSC-3781024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Sus scrofa)
RHEA:67364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-threonyl-L-serine = L-serine + L-threonine
REACT:R-BTA-8850777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK14 (Bos taurus)
REACT:R-HSA-688136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)
REACT:R-HSA-9686709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoating of SARS-CoV-1 Genome (Homo sapiens)
RHEA:32202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:26549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alaninamide + H2O <=> beta-alanine + NH4(+)
RHEA:71607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in)
REACT:R-CEL-2046097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Caenorhabditis elegans)
RHEA:40205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate
RHEA:28231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP
REACT:R-BTA-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
RHEA:23377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonate + NAD(+) => 3-dehydro-D-erythronate + H(+) + NADH
REACT:R-XTR-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)
REACT:R-BTA-3221982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANP binds TP53 (Bos taurus)
REACT:R-DDI-9020274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Dictyostelium discoideum)
REACT:R-MMU-9611751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1,2-agonists bind ADRB1,2 (Mus musculus)
RHEA:16211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)yrinate => Co-precorrin-8X
RHEA:72375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(out) + iodide(in) = hydrogencarbonate(in) + iodide(out)
REACT:R-BTA-912685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBP43 binds IFNAR2 and prevents JAK1 interaction (Bos taurus)
REACT:R-SSC-2750187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Sus scrofa)
EC:1.5.1.45	skos:prefLabel	"FAD reductase [NAD(P)H]"
EC:1.5.1.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FAD reductase [NAD(P)H]"
REACT:R-DME-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Drosophila melanogaster)
RHEA:50590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin F2alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-PGF2alpha + NADP(+)
EC:1.2.1.5	skos:prefLabel	"aldehyde dehydrogenase [NAD(P)(+)]"
EC:1.2.1.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldehyde dehydrogenase [NAD(P)(+)]"
REACT:R-HSA-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
RHEA:52168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:17762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic primary alcohol + NADP(+) => an aromatic aldehyde + H(+) + NADPH
REACT:R-DME-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Drosophila melanogaster)
RHEA:61392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]
REACT:R-MMU-8987156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Mus musculus)
RHEA:46364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Homo sapiens)
REACT:R-CFA-444476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPRL2 receptor binds a wide range of ligands (Canis familiaris)
RHEA:11320	skos:prefLabel	"UDP-arabinose 4-epimerase"
RHEA:11320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-arabinose 4-epimerase"
RHEA:11320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose
REACT:R-HSA-1250463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)
REACT:R-HSA-443774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homodimerization of Neurofascin (Homo sapiens)
REACT:R-DRE-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Danio rerio)
REACT:R-SSC-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Sus scrofa)
REACT:R-MMU-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Mus musculus)
RHEA:35261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O
REACT:R-XTR-75886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Xenopus tropicalis)
RHEA:37131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
RHEA:69253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate => 2-(thiiran-2-yl)acetonitrile + sulfate
RHEA:50532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]
REACT:R-BTA-5218906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 phosphorylates MLKL (Bos taurus)
REACT:R-BTA-209815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is monoiodinated (Bos taurus)
RHEA:23157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime => (indol-3-yl)acetonitrile + H2O
REACT:R-CFA-5362437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are bound by lectins (Canis familiaris)
RHEA:34488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)
REACT:R-CFA-9018894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Canis familiaris)
REACT:R-GGA-9679740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA4:ITGB1 binds natalizumab (Gallus gallus)
RHEA:18122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteine + H2O => a thiol + NH4(+) + pyruvate
GO:0036041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acid binding
GO:0036041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long chain fatty acid binding
REACT:R-MMU-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Mus musculus)
REACT:R-HSA-5692437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANG binds F-actin (Homo sapiens)
REACT:R-MMU-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)
RHEA:48546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine => [phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine
REACT:R-HSA-912503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)
REACT:R-HSA-8961678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 gene expression is stimulated by E2F1 (Homo sapiens)
REACT:R-CEL-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Caenorhabditis elegans)
REACT:R-DDI-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Dictyostelium discoideum)
RHEA:23842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+) => 3-(2,3-dihydroxyphenyl)propanoate + O2
RHEA:16618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->3)-D-glucose + phosphate => alpha-D-glucose 1-phosphate + D-glucose
RHEA:20539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + apo-[ACP] + H(+) => H2O + holo-[ACP]
GO:0055106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-protein transferase regulator activity
GO:0038191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuropilin binding
GO:0038191	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Nrp ligand
GO:0038191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nrp binding
GO:0038191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuropilin-binding
REACT:R-BTA-201457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP2 binds to the receptor complex (Bos taurus)
REACT:R-HSA-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Homo sapiens)
REACT:R-CEL-77613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR2 homodimer to dsRNA duplex (Caenorhabditis elegans)
RHEA:14880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate <=> ADP + L-glutamyl 5-phosphate
RHEA:23345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine D-ribonucleoside + H2O => a purine nucleobase + D-ribose
REACT:R-RNO-9759202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Rattus norvegicus)
REACT:R-CFA-8987161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Canis familiaris)
RHEA:29648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltopentaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotetraose
REACT:R-DDI-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Dictyostelium discoideum)
REACT:R-BTA-174235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdc20 (Bos taurus)
REACT:R-DRE-2395302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysino-5-ketonorleucine cross-links (Danio rerio)
REACT:R-RNO-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Rattus norvegicus)
REACT:R-XTR-375302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules (Xenopus tropicalis)
REACT:R-SSC-6782004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the pre-incision complex in TC-NER (Sus scrofa)
REACT:R-HSA-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Homo sapiens)
REACT:R-CFA-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)
REACT:R-SSC-158756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Sus scrofa)
RHEA:37548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + NAD(+) => 3-dehydro-D-glucose 6-phosphate + H(+) + NADH
REACT:R-DRE-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)
REACT:R-PFA-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Plasmodium falciparum)
REACT:R-MMU-2314686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS2 (Mus musculus)
REACT:R-SSC-5653786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 deISGylates ISG:K164,ISG:K168-PCNA (Sus scrofa)
REACT:R-MMU-174120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)
REACT:R-XTR-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Xenopus tropicalis)
REACT:R-XTR-5627071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Xenopus tropicalis)
RHEA:41364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-CEL-6810464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT14 hydrolyses UDP-Glc to G1P and UMP (Caenorhabditis elegans)
REACT:R-BTA-9006844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21:IL21R:JAK1 binds IL2RG:JAK3 (Bos taurus)
RHEA:25976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-976768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3b (Mus musculus)
RHEA:40591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanedioyl-CoA + H2O = CoA + decanedioate + H(+)
RHEA:56722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate
RHEA:16990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate
RHEA:34038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + paromamine <=> 6'-oxoparomamine + H2O2
RHEA:65966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + taurocholate(in) => ATP + H2O + taurocholate(out)
REACT:R-RNO-8942208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOXE3 isomerises 12R-HpETE to HXA3 (Rattus norvegicus)
REACT:R-XTR-5693542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RPA complexes with ssDNA at resected DNA DSBs (Xenopus tropicalis)
RHEA:56349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)
RHEA:57071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate + ATP <=> 3-oxoisoapionate 4-phosphate + ADP + H(+)
RHEA:60290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine
REACT:R-DME-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Drosophila melanogaster)
RHEA:34079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP
REACT:R-BTA-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Bos taurus)
RHEA:34343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone
RHEA:38989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-nonenoyl-CoA + H2O2 => nonanoyl-CoA + O2
REACT:R-BTA-873922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 by JAK kinases (Bos taurus)
RHEA:18424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + chloramphenicol <=> chloramphenicol 3-acetate + CoA
REACT:R-SSC-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Sus scrofa)
REACT:R-DME-1793182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Drosophila melanogaster)
REACT:R-RNO-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Rattus norvegicus)
REACT:R-HSA-9611277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds P2RY12 antagonists (Homo sapiens)
RHEA:56048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein + UDP-alpha-D-glucose = daidzein 7-O-beta-D-glucoside + UDP
REACT:R-HSA-174447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation on the C-strand of the telomere (Homo sapiens)
RHEA:27458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-iodo-L-tyrosine + iodide + NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + NADPH
REACT:R-DRE-5674496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate MAP2K1 (Danio rerio)
REACT:R-HSA-5675194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPK phosphorylates RAF1 (Homo sapiens)
REACT:R-PFA-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Plasmodium falciparum)
REACT:R-SPO-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)
GO:0003824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme activity
GO:0003824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalytic activity
REACT:R-CEL-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Caenorhabditis elegans)
GO:0004176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent proteolysis
GO:0004176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex (Homo sapiens)
GO:0004176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent peptidase activity
REACT:R-BTA-5687112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 is degraded by the 26S proteasome (Bos taurus)
RHEA:23196	skos:altLabel	"L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase"
RHEA:23196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine = 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
RHEA:23196	skos:prefLabel	"N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase"
RHEA:23196	skos:altLabel	"L-alpha-aminoadipyl-cysteinyl-valine synthetase"
RHEA:23196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase"
RHEA:23196	skos:altLabel	"ACV synthetase"
REACT:R-GGA-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Gallus gallus)
RHEA:31462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate <=> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
REACT:R-MMU-913424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
RHEA:57083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione
REACT:R-SPO-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Schizosaccharomyces pombe)
GO:1901567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid derivative binding
REACT:R-XTR-9709360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 reduces MetHb (Xenopus tropicalis)
RHEA:57632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Danio rerio)
EC:3.1.1.39	skos:prefLabel	"actinomycin lactonase"
EC:3.1.1.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"actinomycin lactonase"
RHEA:54588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine in 25S rRNA = H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine
REACT:R-CFA-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Canis familiaris)
REACT:R-CFA-4085033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Canis familiaris)
RHEA:43362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP => an N-acylsphinganine + UDP-alpha-D-glucose
RHEA:19367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-ribulose 1,5-bisphosphate + H(+) => ATP + D-ribulose 5-phosphate
REACT:R-DME-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)
REACT:R-HSA-210277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-1 (Homo sapiens)
RHEA:53245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Canis familiaris)
REACT:R-CFA-5651789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to POLB ligates SSB (Canis familiaris)
RHEA:51949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol(in) => myo-inositol(out)
REACT:R-RNO-2022887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 N-deacetylates GlcNAc residues in heparan (Rattus norvegicus)
RHEA:28654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + O2 <=> 9-riburonosylhypoxanthine + H(+) + H2O
REACT:R-XTR-6795667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the cytosol (Xenopus tropicalis)
REACT:R-XTR-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Xenopus tropicalis)
RHEA:28343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dITP + H2O => dIMP + diphosphate + H(+)
REACT:R-CEL-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-XTR-2168881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Truncated Alpha-1-Microglobulin binds heme (Xenopus tropicalis)
RHEA:24760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,4-dihydroxyphenylalanine reductive deaminase"
RHEA:24760	skos:altLabel	"reductive deaminase"
RHEA:24760	skos:altLabel	"DOPA-reductive deaminase"
RHEA:24760	skos:altLabel	"DOPARDA"
RHEA:24760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-dopa + NADH = 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)
RHEA:24760	skos:prefLabel	"3,4-dihydroxyphenylalanine reductive deaminase"
REACT:R-CFA-389523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTLA interacts with HVEM (Canis familiaris)
RHEA:17243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + an alpha-amino acid + H(+) => an alpha-amino acid ester + H2O
RHEA:56360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-deoxycarminomycin + H(+) + NADPH + O2 = 13-dihydrocarminomycin + H2O + NADP(+)
REACT:R-BTA-5423647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)
RHEA:63994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-fluorocytidine 5'-phosphate + ADP + H(+) => 5-fluorocytidine + ATP
GO:0160053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-based site-specific recombinase activity
REACT:R-RNO-8849908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM4 binds flotillin-1 (Rattus norvegicus)
GO:0043768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]
GO:0043768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-ribosylhomocysteinase activity
GO:0043768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-ribosylhomocysteine lyase activity
GO:0043768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosylhomocysteinase activity
GO:0043768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LuxS
RHEA:11915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxoprostaglandin E2 + H(+) + NADPH
REACT:R-SPO-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)
GO:0016495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-X3-C chemokine receptor activity
REACT:R-DDI-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Dictyostelium discoideum)
RHEA:62805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 7-demethylsiderin + NADPH + O2 => desertorin A + 2 H2O + NADP(+)
RHEA:41668	skos:prefLabel	"sanguinarine reductase"
RHEA:41668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sanguinarine reductase"
RHEA:41668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + NADP(+) = chelirubine + NADPH
REACT:R-RNO-9640237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)
REACT:R-SSC-8983876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds IL12RB2:IL12RB2 (Sus scrofa)
RHEA:39141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O
REACT:R-HSA-114252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)
REACT:R-DRE-1236964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of peptide bound MHC class I complex to cell surface (Danio rerio)
REACT:R-GGA-373745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK1 homophillic interaction (Gallus gallus)
RHEA:66365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O => 6-methyl-3,7-dioxodecanedioyl-CoA
REACT:R-RNO-212222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 recruits DNA methyltransferases (Rattus norvegicus)
REACT:R-MMU-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Mus musculus)
REACT:R-SSC-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Sus scrofa)
RHEA:12337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxymethoxysuccinate => fumarate + glycolate
RHEA:67719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 oxidized [2Fe-2S]-[protein] <=> H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]
REACT:R-CEL-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:22901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-acetoin + NAD(+) => diacetyl + H(+) + NADH
RHEA:61537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-9612501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates CREB1 (Canis familiaris)
REACT:R-HSA-5651782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 bound to POLB cleaves displaced DNA strand (flap) (Homo sapiens)
REACT:R-MMU-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Mus musculus)
REACT:R-HSA-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Homo sapiens)
GO:0120015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol transfer activity
GO:0120015	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane sterol transfer activity
GO:0120015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol carrier activity
RHEA:69248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sinigrin = (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)
REACT:R-CFA-1112703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 is phosphorylated (Canis familiaris)
RHEA:38555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an all-trans-retinyl ester + H2O = a fatty acid + all-trans-retinol + H(+)
REACT:R-CFA-2396599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)
REACT:R-DRE-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Danio rerio)
REACT:R-DRE-8853792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET tyrosine phosphorylation (Danio rerio)
RHEA:58882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2
RHEA:36064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => diphosphate + kunzeaol
RHEA:37368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine => 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)
REACT:R-GGA-2179387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Gallus gallus)
RHEA:70174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + pemetrexed(in) <=> H(+)(out) + pemetrexed(out)
REACT:R-SSC-6786190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMBL hydrolyses OM to OLMS (Sus scrofa)
RHEA:17306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega),N(omega)-dimethyl-L-arginine => dimethylamine + L-citrulline
REACT:R-CFA-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Canis familiaris)
GO:0047245	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity
GO:0047245	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity
GO:0047245	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity
GO:0047245	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity
GO:0047245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity
REACT:R-SSC-879562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Sus scrofa)
RHEA:50406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein] => (2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein]
REACT:R-MMU-2730858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of BTK/ITK (Mus musculus)
RHEA:64636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + butan-1-ol = butyl benzoate + CoA
REACT:R-SSC-5669012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA binds EDAR (Sus scrofa)
REACT:R-DRE-997311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of TYK2 by PTP1B (Danio rerio)
RHEA:32843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol
RHEA:31765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid => a 2-oxocarboxylate + L-methionine
GO:0018611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toluate dioxygenase activity
REACT:R-BTA-8987150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Bos taurus)
REACT:R-DME-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Drosophila melanogaster)
RHEA:43016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-alkyl-L-cysteine = 2-aminoprop-2-enoate + an alkyl thiol
RHEA:57890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + 4 H(+)(out) + NAD(+) => a quinone + 5 H(+)(in) + NADH
RHEA:15026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthosine => 7-methylxanthosine + S-adenosyl-L-homocysteine
REACT:R-DME-5654510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 binds SPRED1/2 (Drosophila melanogaster)
REACT:R-HSA-5602901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GSS does not synthesize GSH (Homo sapiens)
RHEA:48111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine
REACT:R-MMU-8942607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Mus musculus)
RHEA:41399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
REACT:R-HSA-9683634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerisation of nucleoprotein (Homo sapiens)
GO:0050331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein bound thiamin diphosphate:ATP phosphoryltransferase activity
GO:0050331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDP kinase activity
GO:0050331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin pyrophosphate kinase activity
GO:0050331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:thiamine-diphosphate phosphotransferase activity
GO:0050331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine diphosphate kinase activity
GO:0050331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:thiamin-diphosphate phosphotransferase activity
GO:0050331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin diphosphate kinase activity
GO:0050331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin-diphosphate kinase activity
GO:0050331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin diphosphate phosphotransferase activity
GO:0050331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine-diphosphate kinase activity
RHEA:29517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose
REACT:R-MMU-202394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CARMA1 to Plasma membrane (Mus musculus)
REACT:R-HSA-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Homo sapiens)
RHEA:51302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-phenylalanine => (9Z)-octadecenoate + L-phenylalanine
RHEA:27578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N-tert-butylpiperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + tert-butylamine
GO:0047552	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-ketoaldehyde dehydrogenase activity
GO:0047552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-linked alpha-ketoaldehyde dehydrogenase activity
GO:0047552	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methylglyoxal dehydrogenase activity
GO:0047552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoaldehyde:NADP+ 2-oxidoreductase activity
GO:0047552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoaldehyde dehydrogenase (NADP+) activity
GO:0047552	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-ketoaldehyde dehydrogenase
GO:0047552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent alpha-ketoaldehyde dehydrogenase activity
REACT:R-CEL-5577213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-BTA-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Bos taurus)
REACT:R-CFA-1112604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STATs are released (Canis familiaris)
RHEA:20149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:20149	skos:prefLabel	"quinine 3-monooxygenase"
RHEA:20149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinine 3-monooxygenase"
RHEA:20149	skos:altLabel	"nifedipine oxidase"
RHEA:20149	skos:altLabel	"CYP3A4"
RHEA:20149	skos:altLabel	"quinine 3-hydroxylase"
REACT:R-SPO-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Schizosaccharomyces pombe)
REACT:R-RNO-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Rattus norvegicus)
REACT:R-HSA-2022919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)
RHEA:66680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H(+) + phosphate
REACT:R-BTA-4085021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)
REACT:R-XTR-5423647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2A13 oxidises AFM1 to AFM1E (Xenopus tropicalis)
RHEA:50171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine
RHEA:17440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate <=> (2E,4E)-2,4-dichloromuconate + H(+)
REACT:R-GGA-417820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 receptor can bind to LPA (Gallus gallus)
REACT:R-HSA-2428926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Homo sapiens)
REACT:R-BTA-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Bos taurus)
RHEA:68759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine
REACT:R-XTR-8983063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Xenopus tropicalis)
RHEA:21709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine
RHEA:54249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
REACT:R-XTR-202706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha4beta1 binds JAM2:JAM3 (Xenopus tropicalis)
RHEA:41040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA
REACT:R-XTR-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Xenopus tropicalis)
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	vitamin A binding
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	red-sensitive opsin
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	violet-sensitive opsin
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinal binding
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	blue-sensitive opsin
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short-wave-sensitive opsin
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UV-sensitive opsin
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinaldehyde binding
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	green-sensitive opsin
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-wave-sensitive opsin
GO:0016918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	opsin
RHEA:22776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O2 + 2 Mn(2+) = 2 H2O + 2 Mn(3+)
REACT:R-DRE-9008928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Danio rerio)
REACT:R-CFA-5218841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
REACT:R-SSC-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Sus scrofa)
REACT:R-CEL-166387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The FA anion diffuses away laterally from UCP (Caenorhabditis elegans)
REACT:R-SSC-8848005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 promotes PTK6 autophosphorylation (Sus scrofa)
RHEA:60016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene B
REACT:R-SSC-190265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds to FGF (Sus scrofa)
REACT:R-BTA-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)
REACT:R-XTR-114542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1,RAC2,RHOG activate PI3K (Xenopus tropicalis)
REACT:R-DRE-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Danio rerio)
RHEA:20985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin + H2O => an N-acylsphing-4-enine 1-phosphate + choline + H(+)
RHEA:29308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + methanesulfonate + O2 => FMN + formaldehyde + 2 H(+) + H2O + sulfite
RHEA:40418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pristanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)
REACT:R-GGA-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Gallus gallus)
GO:0070996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 melanocortin receptor binding
GO:0070996	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 melanocortin receptor ligand
REACT:R-CFA-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Canis familiaris)
REACT:R-MMU-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Mus musculus)
REACT:R-CFA-4084989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Canis familiaris)
REACT:R-HSA-9729300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates nucleoprotein (Homo sapiens)
REACT:R-SSC-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Sus scrofa)
REACT:R-XTR-6797568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind CASK:Protein 4.1 (Xenopus tropicalis)
RHEA:36295	skos:prefLabel	"maltose 6'-phosphate phosphatase"
RHEA:36295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maltose 6'-phosphate phosphatase"
RHEA:36295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltose 6'-phosphate + H2O = D-maltose + phosphate
RHEA:36295	skos:altLabel	"maltose 6'-P phosphatase"
REACT:R-CFA-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Canis familiaris)
REACT:R-BTA-1604350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14:TIMP2 binds proMMP2 (Bos taurus)
RHEA:30124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + tetradecanoate
RHEA:56936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-androst-5-en-3-one = testosterone
REACT:R-CFA-2730849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
RHEA:18868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA <=> (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA
REACT:R-CFA-177922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR dimerization (Canis familiaris)
REACT:R-CFA-6805755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 dimethylates TP53 (Canis familiaris)
REACT:R-DRE-8877620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE2 cleaves EDN1(53-90) (Danio rerio)
REACT:R-RNO-8853793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET complexes bind GRB2 (Rattus norvegicus)
REACT:R-GGA-205321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of KIT and sSCF (Gallus gallus)
REACT:R-SSC-2426566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and CLM7 (Sus scrofa)
REACT:R-SSC-1236398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds NRGs or EGF-like ligands (Sus scrofa)
REACT:R-DME-3322016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Drosophila melanogaster)
REACT:R-CFA-379426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Canis familiaris)
REACT:R-MMU-391372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRH1,2 (Mus musculus)
GO:0004577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity
GO:0004577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
GO:0004577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity
GO:0004577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase"
GO:0004577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity
GO:0004577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity
GO:0004577	skos:prefLabel	"N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase"
GO:0004577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP
REACT:R-RNO-140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequestered tissue factor -> tissue factor (Rattus norvegicus)
RHEA:35190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-aminoperacrylic acid + AH2 <=> (Z)-3-aminoacrylate + A + H(+) + H2O
REACT:R-RNO-6797568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind CASK:Protein 4.1 (Rattus norvegicus)
REACT:R-XTR-6799196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Xenopus tropicalis)
RHEA:71874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxybutanoate(out) + H(+)(out) <=> (S)-3-hydroxybutanoate(in) + H(+)(in)
RHEA:39797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate => 7beta-hydroxycholesterol(in) + ATP + H2O
RHEA:45663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-CFA-5686359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPs translocate from extracellular region to clathrin-coated vesicle (Canis familiaris)
GO:0102539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity
REACT:R-SSC-5654643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)
REACT:R-DRE-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Danio rerio)
GO:0052850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH-dependent dihydrocurcumin reductase activity
GO:0052850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocurcumin reductase (NADPH) activity
REACT:R-CFA-6782138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC5 and RPA bind TC-NER site (Canis familiaris)
REACT:R-BTA-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Bos taurus)
RHEA:52255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine
REACT:R-CFA-9641109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Canis familiaris)
REACT:R-MMU-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Mus musculus)
REACT:R-HSA-5218838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXN binds p-6Y,S732-PTK2 (Homo sapiens)
REACT:R-XTR-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Xenopus tropicalis)
REACT:R-SSC-2130619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosomal vesicle coat assembly (Sus scrofa)
RHEA:52766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O
REACT:R-CFA-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Canis familiaris)
RHEA:45940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:52065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)
REACT:R-CEL-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Caenorhabditis elegans)
REACT:R-GGA-482770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet secretory granule components (Gallus gallus)
REACT:R-SSC-6800315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 binds MST1R (Sus scrofa)
RHEA:45064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate
REACT:R-CFA-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)
REACT:R-XTR-9750001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Xenopus tropicalis)
REACT:R-RNO-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Rattus norvegicus)
REACT:R-HSA-5655277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-RNO-216068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with Tenascin-C (Rattus norvegicus)
RHEA:60866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine
RHEA:45262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracosanoate(in) => tetracosanoate(out)
GO:0140803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]
GO:0140803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+- protein-cysteine ADP-ribosyltransferase activity
REACT:R-RNO-5225602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR5 binds Me2sR3-replicative histone H3 (Rattus norvegicus)
REACT:R-RNO-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Rattus norvegicus)
RHEA:11851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine <=> [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate
REACT:R-HSA-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Homo sapiens)
REACT:R-HSA-9027628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises EPA to 5-HEPE (Homo sapiens)
RHEA:63835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-methylnon-6-enoyl-CoA + vanillylamine <=> capsaicin + CoA + H(+)
RHEA:40192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH
REACT:R-MMU-140664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Mus musculus)
REACT:R-CEL-9727607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ binds sacubitrilat (Caenorhabditis elegans)
RHEA:22146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate => cis-aconitate + H2O
REACT:R-CEL-1676162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Caenorhabditis elegans)
RHEA:49304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine
REACT:R-DRE-9661397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)
REACT:R-CFA-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Canis familiaris)
REACT:R-DDI-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Dictyostelium discoideum)
REACT:R-SSC-381612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1 (Sus scrofa)
REACT:R-XTR-877281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 binds p-STAT1 dimer (Xenopus tropicalis)
REACT:R-GGA-913374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits SHIP (Gallus gallus)
GO:0018530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-6-hydroxynicotine oxidase activity
GO:0018530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-D-nicotine oxidase activity
GO:0018530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-6-hydroxynicotine oxidase activity
GO:0018530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-6-hydroxynicotine:oxygen oxidoreductase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclin-dependent protein kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclin D-dependent kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neuronal cdc2-like kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDK
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin-dependent protein kinase, intrinsic catalyst activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclin-A associated kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D-type cyclin kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclin-dependent kinase-4 activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK, catalytic subunit activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:cyclin phosphotransferase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclin D-cdk6 kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cdk-activating kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclin E kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cdc2 kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclin-dependent kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclin-dependent kinase 6 activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin-dependent protein serine/threonine kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Cdk-activating protein kinase activity
GO:0004693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclin-dependent kinase-2 activity
REACT:R-CFA-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Canis familiaris)
REACT:R-DRE-70555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Danio rerio)
RHEA:12613	skos:prefLabel	"glutathione--cystine transhydrogenase"
RHEA:12613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione--cystine transhydrogenase"
RHEA:12613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + L-cystine = glutathione disulfide + 2 L-cysteine
REACT:R-SPO-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Schizosaccharomyces pombe)
REACT:R-RNO-9626832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Rattus norvegicus)
REACT:R-BTA-2424476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV2/3 (Bos taurus)
RHEA:10110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + salutaridine => (7S)-salutaridinol + NADP(+)
REACT:R-DME-177920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2 to GAB1 (Drosophila melanogaster)
REACT:R-BTA-8987132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Bos taurus)
REACT:R-CEL-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Caenorhabditis elegans)
GO:0033799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:myricetin O-methyltransferase activity
GO:0033799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin 3'-O-methyltransferase activity
GO:0033799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myricetin 3-O-methyltransferase activity
GO:0033799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonoid 3',5'-O-dimethyltransferase activity
GO:0033799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CrCOMT2
RHEA:65738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + octanal + succinate + sulfate => 2-oxoglutarate + O2 + octyl sulfate
RHEA:14227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxohexanoate + H(+) + NADH => 6-hydroxyhexanoate + NAD(+)
RHEA:62893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + 2 H2O + nor-toralactone
REACT:R-CFA-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Canis familiaris)
GO:0010309	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase
GO:0010309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ARD1
GO:0010309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)
GO:0010309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E-2'
GO:0010309	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aci-reductone dioxygenase
GO:0010309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ARD'
GO:0010309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acireductone dioxygenase (Fe2+-requiring) activity
GO:0010309	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acireductone dioxygenase activity
GO:0010309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acireductone dioxygenase [iron(II)-requiring] activity
GO:0010309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity
REACT:R-GGA-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Gallus gallus)
RHEA:39039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-oxo fatty acid + H2O + NAD(+) = a dicarboxylate + 2 H(+) + NADH
REACT:R-MMU-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Mus musculus)
RHEA:40919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)
REACT:R-HSA-1449597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AKT2 phosphorylates Myosin 5A (Homo sapiens)
RHEA:39058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esculetin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + scopoletin
REACT:R-SPO-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Schizosaccharomyces pombe)
RHEA:33611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl salicylate = H(+) + methanol + salicylate
REACT:R-CEL-2105001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from DS (Caenorhabditis elegans)
REACT:R-SSC-8848975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS1 (Sus scrofa)
RHEA:43259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate
REACT:R-BTA-5693583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDC1 associates with gamma-H2AFX at nuclear foci (Bos taurus)
RHEA:65368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
REACT:R-HSA-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Homo sapiens)
REACT:R-XTR-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Xenopus tropicalis)
RHEA:27976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-carboxy-7-deazaguanine + NH4(+) => 6-carboxy-5,6,7,8-tetrahydropterin + H(+)
RHEA:24224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) = 4-methylcatechol + CO2 + NADPH
RHEA:24224	skos:prefLabel	"cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase"
RHEA:24224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase"
RHEA:24224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) = 4-methylcatechol + CO2 + NADH
RHEA:47494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isodeoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
REACT:R-DRE-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Danio rerio)
REACT:R-SCE-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Saccharomyces cerevisiae)
REACT:R-BTA-2396009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds c-di-GMP (Bos taurus)
REACT:R-MMU-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Mus musculus)
REACT:R-MMU-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Mus musculus)
RHEA:68020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl phosphate + H2O = (2E)-geraniol + phosphate
REACT:R-HSA-9709317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to free ferrohemoglobin (Homo sapiens)
REACT:R-SSC-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Sus scrofa)
REACT:R-DRE-2574845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA binds centrosome-associated AURKA (Danio rerio)
REACT:R-DME-2018682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Drosophila melanogaster)
REACT:R-CEL-433101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Caenorhabditis elegans)
REACT:R-CFA-450466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1:mRNA complex is destroyed (Canis familiaris)
REACT:R-HSA-159567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform ST to ST-CoA (Homo sapiens)
REACT:R-DRE-2161792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)
REACT:R-HSA-9696266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds effectors (Homo sapiens)
REACT:R-SSC-6803523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Sus scrofa)
REACT:R-HSA-9029551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Homo sapiens)
RHEA:51531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + vanillate <=> CO2 + guaiacol
RHEA:23279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantoate <=> 3-methyl-2-oxobutanoate + formaldehyde
REACT:R-GGA-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Gallus gallus)
REACT:R-DRE-5689544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds INO80 complex (Danio rerio)
RHEA:30219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + H2O + NAD(+) = dimethyl sulfone + H(+) + NADH
RHEA:30219	skos:prefLabel	"dimethylsulfone reductase"
RHEA:30219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylsulfone reductase"
RHEA:71548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphomethyl-dUMP in DNA + glycine => 5-N(alpha)-glycyl-dTMP in DNA + phosphate
RHEA:47215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetate 2-hydroxylase"
RHEA:53392	skos:altLabel	"CYP504"
RHEA:53392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] = (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53392	skos:prefLabel	"phenylacetate 2-hydroxylase"
RHEA:48665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:22245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + UDP-alpha-D-xylose => H(+) + kaempferol 3-O-beta-D-xyloside + UDP
REACT:R-GGA-8953917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Gallus gallus)
REACT:R-RNO-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)
RHEA:16810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate
RHEA:69225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-alkenyl glucosinolate + H2O => a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)
REACT:R-MMU-9013361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEXT3 is cleaved to produce NICD3 (Mus musculus)
RHEA:15894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-sirohydrochlorin + 2 H(+) => Co(2+) + sirohydrochlorin
REACT:R-MMU-4641205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPO:LGR binds ZNRF3 (Mus musculus)
RHEA:65465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-1-ol + butanoyl-CoA => 2-methylbutyl butanoate + CoA
RHEA:13617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-methyl-5'-thioadenosine = 5-(methylsulfanyl)-D-ribose + adenine
RHEA:16152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide
RHEA:18466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa + O2 => 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)
REACT:R-BTA-3769394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CBY1 (Bos taurus)
GO:0044586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellotetraose binding
RHEA:32832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an R-cob(III)alamin(in) => an R-cob(III)alamin(out)
RHEA:72161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + taurocholate(in) => glutarate(in) + taurocholate(out)
GO:0047858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)
GO:0047858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyfumarate carboxy-lyase activity
GO:0047858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyfumarate decarboxylase activity
REACT:R-SSC-177925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds to the phosphorylated EGF receptor:ligand complex (Sus scrofa)
REACT:R-HSA-9754745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates  (Homo sapiens)
RHEA:53480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH = 5alpha-androstane-3beta,17beta-diol + NADP(+)
RHEA:33015	skos:altLabel	"2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase"
RHEA:33015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase"
RHEA:33015	skos:altLabel	"OTEMO"
RHEA:33015	skos:prefLabel	"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase"
RHEA:33015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 = [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)
RHEA:33015	skos:altLabel	"2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase"
REACT:R-DDI-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Dictyostelium discoideum)
REACT:R-CFA-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Canis familiaris)
GO:0050361	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)
GO:0050361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan 2-monooxygenase activity
RHEA:66637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (-)-alpha-acorenol + diphosphate
REACT:R-CFA-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Canis familiaris)
RHEA:71158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoylpyruvate + H2O <=> (E)-caffeate + H(+) + pyruvate
RHEA:21587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propane-1,2-diol 1-phosphate <=> H(+) + hydroxyacetone phosphate + NADH
RHEA:62913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toralactone => 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)
REACT:R-SCE-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Saccharomyces cerevisiae)
REACT:R-XTR-741411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates NEMO (Xenopus tropicalis)
RHEA:44982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-butanoyl-(R)-carnitine => (R)-carnitine + butanoyl-CoA
REACT:R-DRE-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-GGA-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Gallus gallus)
REACT:R-MMU-6782224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)
REACT:R-DRE-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Danio rerio)
REACT:R-CFA-447130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-23 binds interleukin-23 receptor (Canis familiaris)
RHEA:43646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + tetradecanoyl-CoA
RHEA:62785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 fonsecin B + H(+) + NADPH + O2 => bifonsecin B + 2 H2O + NADP(+)
REACT:R-CEL-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)
REACT:R-HSA-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Homo sapiens)
REACT:R-DDI-390251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Dictyostelium discoideum)
RHEA:62997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienamide + H2O => (8Z,11Z,14Z)-eicosatrienoate + NH4(+)
REACT:R-CFA-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Canis familiaris)
RHEA:27513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine <=> dehydro coenzyme F420-0 + GMP + H(+)
RHEA:53738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a halide anion + catechol + CO2 + NAD(+) => a 2-halobenzoate + H(+) + NADH + O2
REACT:R-HSA-8852280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds microtubule lattice in interphase cells (Homo sapiens)
REACT:R-HSA-2105001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from DS (Homo sapiens)
REACT:R-SSC-9645428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 binds ADP-heptose (Sus scrofa)
REACT:R-CEL-1604731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP3 (Caenorhabditis elegans)
REACT:R-CFA-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Canis familiaris)
RHEA:59184	skos:prefLabel	"2,4-diacetylphloroglucinol hydrolase"
RHEA:59184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-diacetylphloroglucinol hydrolase"
RHEA:59184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate
REACT:R-XTR-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Xenopus tropicalis)
REACT:R-SSC-9008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 phosphorylates RUNX2 (Sus scrofa)
REACT:R-SSC-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Sus scrofa)
REACT:R-GGA-448744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20RA binds IL20RB (Gallus gallus)
REACT:R-MMU-5358599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Mus musculus)
REACT:R-RNO-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Rattus norvegicus)
REACT:R-HSA-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
REACT:R-BTA-3132759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds RCbl (Bos taurus)
REACT:R-SCE-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Saccharomyces cerevisiae)
GO:0045551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + H(+) + NADPH
GO:0045551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinnamyl-alcohol dehydrogenase activity
GO:0045551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamyl-alcohol:NADP+ oxidoreductase activity
GO:0045551	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CAD activity
GO:0045551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamyl alcohol dehydrogenase activity
REACT:R-RNO-4615872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO1 (Rattus norvegicus)
REACT:R-SPO-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Schizosaccharomyces pombe)
RHEA:32121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + validoxylamine A 7'-phosphate => GDP-valienol + validamine 7-phosphate
REACT:R-CFA-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Canis familiaris)
REACT:R-HSA-5683425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53BP1 at DNA DSBs (Homo sapiens)
GO:0102835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity
GO:0051019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK binding
GO:0051019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAP-kinase anchoring activity
GO:0051019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP kinase binding
GO:0051019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitogen-activated protein kinase binding
RHEA:53022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + a plastoquinol + NH4(+) => a plastoquinone + an L-alpha-amino acid + H2O
REACT:R-XTR-6814418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes formation of G-beta:G-gamma heterodimers (Xenopus tropicalis)
REACT:R-MMU-5635842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3 phosphorylates GLI (Mus musculus)
RHEA:11109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)
REACT:R-PFA-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Plasmodium falciparum)
REACT:R-MMU-216068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with Tenascin-C (Mus musculus)
REACT:R-HSA-9007606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds BRCA1 gene promoter (Homo sapiens)
REACT:R-GGA-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Gallus gallus)
REACT:R-SSC-5635845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind CDC73 (Sus scrofa)
RHEA:31072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonate semialdehyde + L-alanine => (S)-3-amino-2-methylpropanoate + pyruvate
REACT:R-BTA-109759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Bos taurus)
EC:3.2.1.78	skos:altLabel	"beta-mannanase"
EC:3.2.1.78	skos:prefLabel	"mannan endo-1,4-beta-mannosidase"
EC:3.2.1.78	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannan endo-1,4-beta-mannosidase"
EC:3.2.1.78	skos:altLabel	"endo-1,4-mannanase"
REACT:R-BTA-5656070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFBPs bind FGFs (Bos taurus)
REACT:R-RNO-3788061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by ADAM8 (Rattus norvegicus)
REACT:R-GGA-139919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BIM to mitochondria (Gallus gallus)
RHEA:40496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine
RHEA:10119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP(+) <=> CO2 + D-ribulose 5-phosphate + NADPH
REACT:R-DME-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)
REACT:R-RNO-9013004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the ER membrane (Rattus norvegicus)
RHEA:68581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-kynurenine(out) => ADP + H(+) + L-kynurenine(in) + phosphate
GO:0043779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin-5A acetaldehyde-lyase activity
GO:0043779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin 5A acetaldehyde-lyase activity
REACT:R-BTA-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Bos taurus)
REACT:R-DME-2028629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Drosophila melanogaster)
REACT:R-SSC-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Sus scrofa)
REACT:R-CFA-8938108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds cathepsin L (Canis familiaris)
REACT:R-DRE-429699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 binds ceramide (Danio rerio)
REACT:R-GGA-352927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> glyceraldehyde 3-phosphate (Gallus gallus)
REACT:R-HSA-5655341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 mutants phosphorylate PLCG1 (Homo sapiens)
RHEA:23886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methylnicotinamide + S-adenosyl-L-homocysteine => nicotinamide + S-adenosyl-L-methionine
REACT:R-CFA-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
REACT:R-HSA-5662606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds zinc (Homo sapiens)
RHEA:42391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl crocetin + H(+) + UDP
RHEA:36307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + H2O = 3,4-dihydroxybenzaldehyde + acetyl-CoA
REACT:R-RNO-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Rattus norvegicus)
REACT:R-BTA-1605736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Bos taurus)
GO:0016504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidase activator activity
GO:0016504	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protease activator activity
GO:0016504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NA activation of TGF-beta (Homo sapiens)
GO:0047095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)
GO:0047095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxycyclohexanone 2-monooxygenase activity
REACT:R-RNO-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Rattus norvegicus)
GO:0051730	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GTP-dependent polynucleotide 5'-hydroxyl-kinase activity
GO:0051730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent RNA kinase activity
GO:0051730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent polyribonucleotide kinase activity
GO:0051730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent RNA 5'-hydroxyl-kinase activity
GO:0051730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity
GO:0051730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
REACT:R-SSC-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Sus scrofa)
REACT:R-MMU-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Mus musculus)
GO:0042768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysteroid 2-hydroxylase activity
REACT:R-GGA-917933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Gallus gallus)
REACT:R-CFA-1295609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates SPRY2 on Y55 and Y227 (Canis familiaris)
RHEA:51524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-corytuberine + S-adenosyl-L-methionine = magnoflorine + S-adenosyl-L-homocysteine
RHEA:49427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + validone <=> ADP + H(+) + validone 7-phosphate
RHEA:20792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine--tRNA ligase"
RHEA:20792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
RHEA:20792	skos:prefLabel	"lysine--tRNA ligase"
RHEA:20792	skos:altLabel	"lysyl-tRNA synthetase"
RHEA:20792	skos:altLabel	"lysine translase"
REACT:R-CFA-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Canis familiaris)
REACT:R-RNO-5654692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
REACT:R-MMU-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Mus musculus)
GO:0052667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase activity
GO:0052667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphomethylethanolamine N-methyltransferase activity
GO:0052667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylethanolamine phosphate N-methyltransferase activity
RHEA:42465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2',3-triol + O2 => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)
RHEA:59348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltobiono-1,5-lactone + H2O = D-maltobionate + H(+)
REACT:R-CFA-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Canis familiaris)
RHEA:12447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanal + NADP(+) <=> (2E)-hexadecenal + H(+) + NADPH
REACT:R-XTR-70920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Xenopus tropicalis)
REACT:R-BTA-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Bos taurus)
REACT:R-RNO-199161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fc gamma receptors interact with antigen-bound IgG (Rattus norvegicus)
REACT:R-HSA-195926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association with M1 at cell membrane (Homo sapiens)
REACT:R-HSA-9020513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIN2B gene expression is inhibited by MECP2 (Homo sapiens)
REACT:R-DME-1971491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Drosophila melanogaster)
RHEA:54722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
REACT:R-GGA-8864595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2B homodimer binds YEATS4 (Gallus gallus)
RHEA:43639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-DRE-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Danio rerio)
RHEA:70519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-octopamine + S-adenosyl-L-methionine = (R)-synephrine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-1989776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of APOA2 (Homo sapiens)
REACT:R-GGA-372741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Gallus gallus)
REACT:R-SPO-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Schizosaccharomyces pombe)
REACT:R-DRE-170977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 is phosphorylated by active TrkA receptor (Danio rerio)
REACT:R-BTA-383313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like Peptide 1 is secreted from intestinal L cells (Bos taurus)
REACT:R-RNO-2213244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides (Rattus norvegicus)
REACT:R-HSA-5671702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP1G2 binds HGS and CHMP2A (Homo sapiens)
RHEA:69163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O + O2 <=> H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)
RHEA:33071	skos:prefLabel	"2-deoxy-scyllo-inosose synthase"
RHEA:33071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-deoxy-scyllo-inosose synthase"
RHEA:33071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate
REACT:R-HSA-374251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARC  is a non-specific receptor for many chemokines (Homo sapiens)
REACT:R-HSA-8941312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Homo sapiens)
RHEA:15930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 H2O + methylenediurea => CO2 + N-(hydroxymethyl)urea + 2 NH4(+)
REACT:R-DDI-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Dictyostelium discoideum)
REACT:R-HSA-109759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Homo sapiens)
REACT:R-MMU-444838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 1 binds relaxin 2 and 3 (Mus musculus)
REACT:R-CEL-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Caenorhabditis elegans)
RHEA:68779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> diphosphate + germacrene A
REACT:R-CFA-8857692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA demethylases demethylate N6-methyladenosine RNA (Canis familiaris)
RHEA:67020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:67020	skos:altLabel	"mRNA (nucleoside-2'-O)-methyltransferase"
RHEA:67020	skos:prefLabel	"methyltransferase cap1"
RHEA:67020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methyltransferase cap1"
RHEA:67020	skos:altLabel	"messenger RNA (nucleoside-2'-)-methyltransferase"
RHEA:67020	skos:altLabel	"cap1-MTase"
REACT:R-SSC-6814885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)
RHEA:66836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] = asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]
RHEA:32988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol
REACT:R-HSA-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Homo sapiens)
REACT:R-SSC-1678921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length TLR3/7/8/9 binds to UNC93B1 (Sus scrofa)
REACT:R-CFA-174447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation on the C-strand of the telomere (Canis familiaris)
REACT:R-DRE-1638803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at centromeres (Danio rerio)
REACT:R-XTR-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Xenopus tropicalis)
REACT:R-SSC-2395324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyrrole cross-links (Sus scrofa)
REACT:R-SSC-8987120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IFNLR1 (Sus scrofa)
GO:0009029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetraacyldisaccharide 4'-kinase activity
GO:0009029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipid-A 4'-kinase activity
GO:0009029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity
REACT:R-GGA-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Gallus gallus)
REACT:R-HSA-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Homo sapiens)
RHEA:69035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dihydroxy-L-aspartate <=> (2S)-2-nitrosobutanedioate + H2O
GO:0048529	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)
GO:0048529	skos:altLabel	"Mg-protoporphyrin IX monomethyl ester oxidative cyclase"
GO:0048529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase"
GO:0048529	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity
GO:0048529	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity
GO:0048529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity
GO:0048529	skos:prefLabel	"magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase"
GO:0048529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)
RHEA:24076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADH
REACT:R-CFA-9018863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Canis familiaris)
REACT:R-CFA-2213201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibres (Canis familiaris)
RHEA:42827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NAD(+) + tetracenomycin C
REACT:R-CEL-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Caenorhabditis elegans)
REACT:R-CFA-1370500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR binds SCF beta-TrCP complex (Canis familiaris)
REACT:R-MMU-76426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-atom dealkylation of caffeine (Mus musculus)
RHEA:49000	skos:altLabel	"aurachin C monooxygenase"
RHEA:49000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)
RHEA:49000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADPH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)
RHEA:49000	skos:prefLabel	"aurachin C monooxygenase/isomerase"
RHEA:49000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aurachin C monooxygenase/isomerase"
REACT:R-SSC-5423672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2, 3A4 oxidise AFB1 to AFNBO (Sus scrofa)
RHEA:31719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-9638076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)
RHEA:27327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-2197698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src phosphorylate WASP,N-WASP (Canis familiaris)
REACT:R-HSA-4647593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP400 binds CDKN1A promoter (Homo sapiens)
REACT:R-XTR-1307963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Xenopus tropicalis)
RHEA:15221	skos:altLabel	"CDP-diacylglycerol phosphatidylhydrolase"
RHEA:15221	skos:prefLabel	"CDP-diacylglycerol diphosphatase"
RHEA:15221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-diacylglycerol diphosphatase"
RHEA:15221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)
RHEA:15221	skos:altLabel	"CDP-diacylglycerol pyrophosphatase"
RHEA:64472	skos:altLabel	"methylthiohydroxybutyrate methyltransferase"
RHEA:64472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine = (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine
RHEA:64472	skos:prefLabel	"2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase"
RHEA:64472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase"
RHEA:64472	skos:altLabel	"MTHB methyltransferase"
RHEA:39545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH
REACT:R-SSC-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Sus scrofa)
RHEA:13242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-fucose => ADP + beta-L-fucose 1-phosphate + H(+)
RHEA:58581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate => acetate + catharanthine + H(+)
RHEA:33820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate => 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate
RHEA:14059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacylglycerophospholipid + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a glycerophospholipid
RHEA:35237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + tetracycline(out) => H(+)(out) + tetracycline(in)
RHEA:37699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
REACT:R-DRE-9033959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Danio rerio)
RHEA:48851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> 13-hydroperoxy-(9Z,11E)-octadecadienoate
RHEA:39201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetracosenoyl-CoA + H2O => (3R)-hydroxytetracosanoyl-CoA
REACT:R-HSA-1483142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is transphosphatidylated to PG by PLD1-4/6 (Homo sapiens)
GO:0004974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene receptor activity
REACT:R-CFA-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Canis familiaris)
REACT:R-BTA-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Bos taurus)
RHEA:55811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:61251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tyrosine + O2 <=> 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)
RHEA:61865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dehydroprobetaenone I => A + probetaenone I
REACT:R-CFA-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Canis familiaris)
REACT:R-DRE-198621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates caspase-9 (Danio rerio)
RHEA:72349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole
REACT:R-DME-71324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)
REACT:R-DDI-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Dictyostelium discoideum)
REACT:R-MMU-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)
REACT:R-DME-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Drosophila melanogaster)
RHEA:71836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) => estrone 3-sulfate(in)
RHEA:67819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O <=> a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate
RHEA:41610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha,alpha-trehalose
RHEA:39990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol <=> all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
RHEA:62791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 fonsecin B + H(+) + NADPH + O2 <=> aurasperone B + 2 H2O + NADP(+)
REACT:R-SCE-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Saccharomyces cerevisiae)
REACT:R-PFA-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-MMU-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Mus musculus)
REACT:R-HSA-204169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP dephosphorylates p-lipo-PDH (Homo sapiens)
REACT:R-SSC-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)
RHEA:65649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine => a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine
RHEA:12968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-galacturonate <=> 1-phospho-alpha-D-galacturonate + ADP + H(+)
REACT:R-RNO-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Rattus norvegicus)
RHEA:67198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + serotonin => H2O + N-acetylserotonin
REACT:R-CFA-174690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Canis familiaris)
RHEA:44124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + tetradecan-1-ol = CoA + tetradecanyl hexadecanoate
RHEA:15972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + H(+) + methylarsonate <=> glutathione disulfide + H2O + methylarsonous acid
REACT:R-GGA-419440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate (Gallus gallus)
RHEA:42552	skos:prefLabel	"tRNA pseudouridine(31) synthase"
RHEA:42552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(31) in tRNA = pseudouridine(31) in tRNA
RHEA:42552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA pseudouridine(31) synthase"
RHEA:53057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine
RHEA:55005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxylimonen-2-one + NADPH + O2 => 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)
RHEA:64474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine
RHEA:61643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isophthalyl-CoA <=> benzoyl-CoA + CO2
RHEA:19898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 L-arginine + 3 NADPH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide
REACT:R-SSC-3788745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL8 promoter (Sus scrofa)
RHEA:38713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol
REACT:R-BTA-5625848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Bos taurus)
REACT:R-HSA-169901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1-GTP complex binds BRAF complex (Homo sapiens)
REACT:R-DDI-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Dictyostelium discoideum)
REACT:R-SSC-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Sus scrofa)
REACT:R-CFA-2672334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNN channels transport extracellular Na+ to cytosol (Canis familiaris)
RHEA:47398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic alcohol + H(+) + octadecanoate => H2O + octadecanoate ester
RHEA:63691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)
REACT:R-GGA-1602473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP1 (Gallus gallus)
RHEA:22283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-demethylpuromycin + S-adenosyl-L-methionine <=> H(+) + puromycin + S-adenosyl-L-homocysteine
RHEA:41037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA
RHEA:64475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine <=> (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine
REACT:R-HSA-5218828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2/SRC-1 phosphorylates BCAR1 (Homo sapiens)
REACT:R-MMU-202307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Change of PKC theta conformation (Mus musculus)
RHEA:30186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH
RHEA:61455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + oxytetracycline <=> 11a-hydroxy-oxytetracycline + H2O + NADP(+)
REACT:R-SSC-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Sus scrofa)
REACT:R-MMU-448421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 translocates from the ER lumen to the extracellular region (Mus musculus)
REACT:R-RNO-391940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 and EP4 receptors can bind PGE2 (Rattus norvegicus)
RHEA:19020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADHX + ATP <=> ADP + H(+) + NADH + phosphate
REACT:R-SSC-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Sus scrofa)
REACT:R-HSA-9768782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-224 represses NPAS4 mRNA translation (Homo sapiens)
RHEA:25161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ornithine => L-glutamate + L-glutamate 5-semialdehyde
REACT:R-CEL-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)
GO:0018612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene dioxygenase activity
REACT:R-SSC-9624668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDKN1A (p21) (Sus scrofa)
REACT:R-BTA-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Bos taurus)
REACT:R-MMU-77584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Mus musculus)
REACT:R-BTA-5654404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds SHC1 (Bos taurus)
REACT:R-BTA-381518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAAP-A proteolyzes IGF:IGFBP4 (Bos taurus)
RHEA:30924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)
RHEA:72051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
RHEA:40400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)
RHEA:72136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine(out) => putrescine(in)
REACT:R-BTA-8851919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 and GRB2 (Bos taurus)
REACT:R-HSA-444731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)
EC:1.17.7.4	skos:prefLabel	"4-hydroxy-3-methylbut-2-enyl diphosphate reductase"
EC:1.17.7.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-3-methylbut-2-enyl diphosphate reductase"
EC:1.17.7.4	skos:altLabel	"(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase"
EC:1.17.7.4	skos:altLabel	"HMBPP reductase"
RHEA:67290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine => ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine
REACT:R-GGA-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Gallus gallus)
REACT:R-HSA-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Homo sapiens)
REACT:R-HSA-380203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)
REACT:R-BTA-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Bos taurus)
REACT:R-SPO-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Schizosaccharomyces pombe)
REACT:R-SPO-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Schizosaccharomyces pombe)
REACT:R-CFA-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Canis familiaris)
REACT:R-DME-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Drosophila melanogaster)
REACT:R-BTA-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Bos taurus)
REACT:R-CEL-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Caenorhabditis elegans)
REACT:R-BTA-5696131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC1 deaminates Hist (Bos taurus)
GO:0042835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRE binding
REACT:R-DRE-6801195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3 binds BNIP3L (Danio rerio)
REACT:R-BTA-751039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (12/13) reassociates with G beta:gamma (Bos taurus)
REACT:R-XTR-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Xenopus tropicalis)
RHEA:11311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ATP + hydrogencarbonate <=> ADP + H(+) + malonyl-CoA + phosphate
RHEA:44901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactono-1,4-lactone + H2O => D-galactonate + H(+)
REACT:R-RNO-2509793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses dIDP to dIMP (Rattus norvegicus)
REACT:R-DDI-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)
REACT:R-MMU-445113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Urotensin-2 receptor binds urotensin-2 and 2B (Mus musculus)
RHEA:69596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + inosine = adenosine + IMP
RHEA:10444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + S-adenosyl-L-methionine = (S)-laudanine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Danio rerio)
REACT:R-GGA-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Gallus gallus)
RHEA:54993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + FMN + H2O + L-glutamate + O2 => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)
REACT:R-RNO-374673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds RanBPM (Rattus norvegicus)
RHEA:30040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 => benzene-1,2,4-triol + CO2 + H2O + NADP(+)
REACT:R-DRE-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Danio rerio)
REACT:R-CFA-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Canis familiaris)
REACT:R-BTA-4641256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated AXIN is degraded by the proteasome (Bos taurus)
REACT:R-GGA-9013361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEXT3 is cleaved to produce NICD3 (Gallus gallus)
REACT:R-HSA-6801213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates TRIAP1 expression (Homo sapiens)
REACT:R-HSA-77263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Homo sapiens)
RHEA:24013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol + S-adenosyl-L-methionine => (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine
RHEA:22711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-acylglutathione <=> a carboxylate + glutathione + H(+)
REACT:R-DME-3134804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING ubiquitination by TRIM32 or TRIM56 (Drosophila melanogaster)
REACT:R-HSA-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Homo sapiens)
REACT:R-RNO-3149518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRR reduces cob(II)alamin to meCbl (Rattus norvegicus)
RHEA:51666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-carbamoyl-D-phenylglycine => D-5-phenylhydantoin + H2O
RHEA:47680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-phosphate + NH4(+)
RHEA:18985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isochorismate synthase"
RHEA:18985	skos:altLabel	"isochorismate mutase"
RHEA:18985	skos:altLabel	"isochorismate synthetase"
RHEA:18985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate = isochorismate
RHEA:18985	skos:prefLabel	"isochorismate synthase"
REACT:R-CEL-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Caenorhabditis elegans)
GO:0050172	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine oxidase (deaminating and decarboxylating)
GO:0050172	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	l-phenylalanine oxidase (deaminating and decarboxylating) activity
GO:0050172	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine (deaminating, decarboxylating) oxidase activity
GO:0050172	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine (deaminating, decarboxylating)oxidase activity
GO:0050172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine 2-monooxygenase activity
GO:0050172	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)
RHEA:15911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetaldehyde + CO2 + H(+) + succinate + sulfite => 2-oxoglutarate + O2 + taurine
REACT:R-BTA-8956184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Bos taurus)
REACT:R-DRE-8983845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dissociates from IL6ST:IL6ST (Danio rerio)
RHEA:59555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N',N'',N'''-tetraacetylchitotetraose + O2 <=> H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone
REACT:R-RNO-450580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 (hnRNP D0) is ubiquitinylated (Rattus norvegicus)
RHEA:33055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 3'-diphosphate 5'-triphosphate + H2O = diphosphate + GTP + H(+)
RHEA:62150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGDP + dTDP => dGTP + dTMP
REACT:R-CFA-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Canis familiaris)
RHEA:43492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyll a + NADP(+) = chlorophyll b + H(+) + NADPH
RHEA:68982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + tauroursodeoxycholate
RHEA:23315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 sucrose <=> 1(F)-beta-D-fructosylsucrose + D-glucose
REACT:R-MMU-5682709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI4 binds ADAM22,23,11 (Mus musculus)
REACT:R-CFA-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Canis familiaris)
REACT:R-RNO-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Rattus norvegicus)
GO:0000033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3-mannosyltransferase activity
RHEA:69313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => benzyl thiocyanate + sulfate
REACT:R-XTR-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)
REACT:R-SSC-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Sus scrofa)
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exopectic acid transeliminase activity
GO:0047489	skos:prefLabel	"pectate disaccharide-lyase"
GO:0047489	skos:altLabel	"exopolygalacturonic acid-trans-eliminase"
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) = 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Exo-PGL activity
GO:0047489	skos:altLabel	"PATE"
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exopolygalacturonate lyase activity
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exopectate lyase activity
GO:0047489	skos:altLabel	"exopectate lyase"
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-PGL
GO:0047489	skos:altLabel	"pectate exo-lyase"
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity
GO:0047489	skos:altLabel	"exopectic acid transeliminase"
GO:0047489	skos:altLabel	"exo-PATE"
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exopolygalacturonic acid-trans-eliminase activity
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Exo-PATE activity
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectate exo-lyase activity
GO:0047489	skos:altLabel	"exo-PGL"
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pectate disaccharide-lyase activity
GO:0047489	skos:altLabel	"exopolygalacturonate lyase"
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PATE activity
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-PATE
GO:0047489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pectate disaccharide-lyase"
REACT:R-DDI-109759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Dictyostelium discoideum)
RHEA:71029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + L-phenylalanine(in) => L-glutamine(in) + L-phenylalanine(out)
REACT:R-DME-3132737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate ETS1 and ETS2 (Drosophila melanogaster)
RHEA:19056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin
REACT:R-DDI-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Dictyostelium discoideum)
REACT:R-HSA-2024100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLCE epimerises GlcA to IdoA (Homo sapiens)
GO:0033834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity
GO:0033834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	F3GalTase activity
GO:0033834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 3-O-galactosyltransferase activity
REACT:R-CFA-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Canis familiaris)
REACT:R-DME-8869633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NR to yield NMN (Drosophila melanogaster)
REACT:R-HSA-9020259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Homo sapiens)
REACT:R-XTR-5655835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Xenopus tropicalis)
REACT:R-BTA-9749494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBIP binds IKBKB and CHUK (Bos taurus)
REACT:R-SPO-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Schizosaccharomyces pombe)
RHEA:41692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)
GO:0043776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin 6B C5-methyltransferase activity
GO:0043776	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	precorrin-6Y methylase
GO:0043776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6 methyltransferase activity
GO:0043776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin-6B C5-methyltransferase activity
GO:0043776	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	precorrin-6Y C5,15-methyltransferase (decarboxylating)
RHEA:18769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate
RHEA:18769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-diketo-5-methylthiopentyl-1-phosphate enolase"
RHEA:18769	skos:altLabel	"DK-MTP-1-P enolase"
RHEA:18769	skos:altLabel	"RuBisCO-like protein"
RHEA:18769	skos:prefLabel	"2,3-diketo-5-methylthiopentyl-1-phosphate enolase"
RHEA:69893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) + thymidine(in) => Na(+)(out) + thymidine(out)
REACT:R-SSC-2046096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Sus scrofa)
REACT:R-XTR-73632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Xenopus tropicalis)
RHEA:42867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermine + S-methyl-5'-thioadenosine
REACT:R-RNO-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Rattus norvegicus)
RHEA:55252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:70461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2
REACT:R-SCE-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Saccharomyces cerevisiae)
REACT:R-DME-71541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Drosophila melanogaster)
REACT:R-SSC-5666104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Sus scrofa)
RHEA:69238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutylnitrile + sulfate + sulfur => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate
REACT:R-BTA-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Bos taurus)
REACT:R-SSC-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Sus scrofa)
RHEA:71756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + 2-oxoheptanedioate(in) => 2-oxoglutarate(in) + 2-oxoheptanedioate(out)
RHEA:48964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O
RHEA:72431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + ATP + H(+) = (E)-caffeoyl-AMP + diphosphate
REACT:R-MMU-8956659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates YAP1 (Mus musculus)
REACT:R-GGA-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Gallus gallus)
RHEA:17749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinoline = AH2 + quinolin-2(1H)-one
REACT:R-BTA-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)
RHEA:62428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA = 3,4-dihydroxybenzaldehyde + acetyl-CoA
RHEA:68939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + nonanoate <=> AMP + diphosphate + NADP(+) + nonanal
GO:0030696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (m5U54) methyltransferase activity
GO:0030696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUMT
REACT:R-HSA-8864431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A,TFAP2C homodimers stimulate CGB3 gene expression (Homo sapiens)
GO:0099618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucuronic acid dehydrogenase activity
GO:0099618	skos:prefLabel	"UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)"
GO:0099618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-GlcUA decarboxylase activity
GO:0099618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-alpha-D-glucuronate = CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose
GO:0099618	skos:altLabel	"ArnADH"
GO:0099618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)"
GO:0099618	skos:altLabel	"UDP-GlcUA decarboxylase"
REACT:R-GGA-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Gallus gallus)
REACT:R-SSC-430076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds 14-3-3-zeta (Sus scrofa)
RHEA:54638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + labda-7,13(16),14-triene => (13E)-labda-7,13-dien-15-yl diphosphate
REACT:R-DME-429767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Drosophila melanogaster)
REACT:R-DME-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Drosophila melanogaster)
EC:3.1.1.118	skos:prefLabel	"phospholipid sn-1 acylhydrolase"
EC:3.1.1.118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phospholipid sn-1 acylhydrolase"
EC:3.1.1.118	skos:altLabel	"phosphatidic acid-preferring phospholipase A1"
EC:3.1.1.118	skos:altLabel	"PA-PLA1"
EC:3.1.1.118	skos:altLabel	"phospholipase DDHD1"
REACT:R-BTA-168166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
RHEA:43938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione => androst-5-ene-3,17-dione
RHEA:63645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-seryl-[protein] => 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)
RHEA:71912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate(out) + 2 Na(+)(out) => cholate(in) + 2 Na(+)(in)
GO:0062181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
GO:0062181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
REACT:R-CEL-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Caenorhabditis elegans)
REACT:R-CEL-9688459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds HSP90:CDC37 (Caenorhabditis elegans)
REACT:R-CFA-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Canis familiaris)
RHEA:69847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in RNA + NADP(+) = a uridine in RNA + H(+) + NADPH
RHEA:19497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate = beta-alanine + CO2
RHEA:19497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate 1-decarboxylase"
RHEA:19497	skos:altLabel	"L-aspartate 1-carboxy-lyase"
RHEA:19497	skos:prefLabel	"aspartate 1-decarboxylase"
RHEA:19497	skos:altLabel	"aspartate alpha-decarboxylase"
GO:0032143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single thymine insertion binding
RHEA:10943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (4R)-limonene + diphosphate
GO:0005515	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycoprotein binding
GO:0005515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein binding
GO:0005515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein amino acid binding
GO:0102634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity
REACT:R-HSA-159729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
REACT:R-CEL-1602399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLB1 (Caenorhabditis elegans)
REACT:R-CFA-420980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Canis familiaris)
REACT:R-GGA-8940388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPLD1 hydrolyses GPI-anchors from proteins (Gallus gallus)
REACT:R-RNO-8937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)
RHEA:28481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate(in) + H(+)(in) <=> galactarate(out) + H(+)(out)
REACT:R-CEL-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Caenorhabditis elegans)
RHEA:16394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juvenile hormone II => H(+) + juvenile hormone II carboxylate + methanol
RHEA:24383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)
RHEA:30312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine
RHEA:43417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:41262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan <=> (E)-3-(indol-3-yl)acrylate + NH4(+)
REACT:R-BTA-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)
REACT:R-RNO-70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Rattus norvegicus)
REACT:R-XTR-1981157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of collagen propeptide hydroxylysines (Xenopus tropicalis)
RHEA:40474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-methylpentadecanoyl-CoA + O2 <=> 2-methyl-(2E)-pentadecenoyl-CoA + H2O2
REACT:R-HSA-8865547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds FOXP3 gene (Homo sapiens)
REACT:R-DME-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Drosophila melanogaster)
RHEA:55863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Homo sapiens)
RHEA:16920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypyridine + H(+) + NADH + O2 <=> 2,3,6-trihydroxypyridine + H2O + NAD(+)
REACT:R-MMU-199404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40L binds CD40 (Mus musculus)
RHEA:72576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O => (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA
RHEA:10383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + orotidine 5'-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + orotate
RHEA:43675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-DME-6786048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Drosophila melanogaster)
REACT:R-SSC-173725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C9 binds C5b:C6:C7:C8 (Sus scrofa)
REACT:R-DDI-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Dictyostelium discoideum)
RHEA:15250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose => 1-O-galloyl-beta-D-glucose + UDP
REACT:R-HSA-9670874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIXa variant:FVIIIa does not convert FX to the active FXa (Homo sapiens)
RHEA:59492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + L-tryptophyl-[protein] = (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate
RHEA:49399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
RHEA:30270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 monodehydro-L-ascorbate radical <=> L-ascorbate + L-dehydroascorbate
REACT:R-HSA-376145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP binds ROBO1:SLIT2 (Homo sapiens)
RHEA:25679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-phospho-L-serine + tRNA(Cys) => AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)
RHEA:10177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH
REACT:R-PFA-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)
RHEA:56764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 = 12-epi-fischerindole G + CO2 + H2O + succinate
RHEA:24787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2
RHEA:21241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]
GO:0005324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acid transporter activity
GO:0005324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)
RHEA:39665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + reduced coenzyme F420-(gamma-L-Glu)(n) => a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-BTA-844438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 oligomerizes (Bos taurus)
RHEA:40847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + FAD + H(+) = (2E)-eicosenoyl-CoA + FADH2
RHEA:27468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) <=> ADP-D-glycero-beta-D-manno-heptose + diphosphate
REACT:R-DME-5654407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates SHC1 (Drosophila melanogaster)
REACT:R-MMU-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Mus musculus)
RHEA:62264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) = hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)
REACT:R-BTA-1855219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Bos taurus)
REACT:R-HSA-5663264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RORA, EP300 bind CPT1A gene (Homo sapiens)
RHEA:71491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)
RHEA:11230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-flavanone + H(+) + NADPH => (2S)-flavan-4-ol + NADP(+)
REACT:R-MMU-8874083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y397-PTK2 binds SRC (Mus musculus)
REACT:R-MMU-9635743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 binds p-T,Y-MAPK (Mus musculus)
RHEA:17287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose
RHEA:28173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-2-methylbutanenitrile <=> butan-2-one + hydrogen cyanide
REACT:R-CFA-9649108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer binds 5HT (Canis familiaris)
REACT:R-HSA-5633441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes (Homo sapiens)
REACT:R-SCE-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Saccharomyces cerevisiae)
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription
GO:0001227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding
REACT:R-HSA-9010647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO3.1 binds AKAP5 (Homo sapiens)
GO:0047025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity
GO:0047025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoacyl-acyl-carrier-protein reductase (NADH)
GO:0047025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-ACP reductase (NADH) activity
GO:0047025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity
GO:0047025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity
GO:0047025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity
REACT:R-HSA-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Homo sapiens)
REACT:R-BTA-1169406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host proteins (Bos taurus)
RHEA:71309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-valine(in) + 2 Na(+)(in) => chloride(out) + L-valine(out) + 2 Na(+)(out)
REACT:R-RNO-8866269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB bind GPCRs (Rattus norvegicus)
REACT:R-GGA-5218830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates PTK2-beta (Gallus gallus)
REACT:R-RNO-399978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase C, alpha type phosphorylates MARCKS (Rattus norvegicus)
REACT:R-SPO-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Schizosaccharomyces pombe)
RHEA:18655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-3-ureidopropanoate => barbiturate + H2O
REACT:R-BTA-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Bos taurus)
REACT:R-RNO-183094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds CBL:Beta-Pix (Rattus norvegicus)
REACT:R-DME-3788075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by ADAMTS4, ADAMTS5 (Drosophila melanogaster)
REACT:R-DRE-1254251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds YAP1 (Danio rerio)
REACT:R-RNO-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Rattus norvegicus)
REACT:R-SSC-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Sus scrofa)
RHEA:47270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monoanhydrobacterioruberin => bacterioruberin
REACT:R-SPO-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Schizosaccharomyces pombe)
RHEA:52677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine
GO:0036458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hepatocyte growth factor binding
GO:0036458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF binding
REACT:R-SSC-374298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid receptors bind opioid peptides (Sus scrofa)
RHEA:14148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanidinoacetate <=> ADP + H(+) + phosphoguanidinoacetate
REACT:R-RNO-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)
REACT:R-GGA-2454118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cRAL binds to opsin to form 11c-retinyl:RHO (Gallus gallus)
REACT:R-XTR-158300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Xenopus tropicalis)
RHEA:62246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine-thymine dinucleotide in DNA => a cytidine(6-4)thymidine in DNA
REACT:R-SSC-5632738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDIT4 binds 14-3-3 dimer (Sus scrofa)
REACT:R-MMU-1358801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds RNF41 ubiquitin ligase (Mus musculus)
RHEA:49872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid ketone + a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)
RHEA:20941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)
REACT:R-SCE-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)
REACT:R-SSC-8932275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Sus scrofa)
RHEA:43484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
REACT:R-DRE-9023632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Danio rerio)
REACT:R-MMU-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Mus musculus)
REACT:R-HSA-2396599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
REACT:R-SSC-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Sus scrofa)
RHEA:21336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH
RHEA:21336	skos:prefLabel	"pyridoxal 4-dehydrogenase"
RHEA:21336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxal 4-dehydrogenase"
REACT:R-MMU-5626982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF binds GNB2L1 (Mus musculus)
RHEA:48412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside IV3GalNAc-Gb4Cer + H2O = globoside Gb4Cer + N-acetyl-alpha-D-galactosamine
RHEA:15097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate formimidoyltransferase"
RHEA:15097	skos:altLabel	"formiminoglutamic formiminotransferase"
RHEA:15097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate
RHEA:15097	skos:prefLabel	"glutamate formimidoyltransferase"
RHEA:15097	skos:altLabel	"glutamate formyltransferase"
RHEA:15097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formimidoyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate
RHEA:15097	skos:altLabel	"glutamate formiminotransferase"
RHEA:15097	skos:altLabel	"formiminoglutamic acid transferase"
REACT:R-CFA-2022887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 N-deacetylates GlcNAc residues in heparan (Canis familiaris)
RHEA:57967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1592436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP9 by MMPs (Homo sapiens)
RHEA:59908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanal + NADP(+) = 2 H(+) + hexanoate + NADPH
REACT:R-BTA-8866268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADBRK1,2 phosphorylate AVPR2 (Bos taurus)
REACT:R-XTR-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-SCE-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Saccharomyces cerevisiae)
RHEA:20669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
RHEA:56362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-dihydrocarminomycin + H2O + NADP(+) => 13-deoxycarminomycin + H(+) + NADPH + O2
GO:0106009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
RHEA:32129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2
RHEA:43332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine
REACT:R-MMU-176474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Mus musculus)
RHEA:28393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-psicosyl)-L-lysine <=> N(6)-(D-fructosyl)-L-lysine
REACT:R-SSC-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Sus scrofa)
RHEA:12229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-aspartate + L-glutamine => AMP + diphosphate + H(+) + L-asparagine + L-glutamate
RHEA:26216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate + H2O <=> aphidicolan-16beta-ol + diphosphate
REACT:R-BTA-1602368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Bos taurus)
RHEA:46436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]
REACT:R-GGA-194308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Gallus gallus)
REACT:R-XTR-8877311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB31 GEFs exchange GTP for GDP on RAB31 (Xenopus tropicalis)
REACT:R-CEL-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Caenorhabditis elegans)
REACT:R-HSA-2752125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds integrins alphaVbeta1, alphaVbeta3, alphaVbeta5 (Homo sapiens)
REACT:R-HSA-158756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Homo sapiens)
REACT:R-DME-451811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YKI binds to WTS (Drosophila melanogaster)
GO:0030624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U6atac snRNA binding
REACT:R-GGA-352108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Gallus gallus)
REACT:R-HSA-139970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO3:FAD N-oxidises TMA to TMAO (Homo sapiens)
REACT:R-HSA-9754616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 E pentamer transports Ca2+  (Homo sapiens)
RHEA:49519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 <=> an adenosine in mRNA + CO2 + formaldehyde + succinate
REACT:R-RNO-2473186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FSTL3 binds Activin (Rattus norvegicus)
GO:0047716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazole N-acetyltransferase activity
GO:0047716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazole acetylase activity
GO:0047716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazole acetyltransferase activity
GO:0047716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:imidazole N-acetyltransferase activity
REACT:R-DRE-8853753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Danio rerio)
REACT:R-CFA-77613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR2 homodimer to dsRNA duplex (Canis familiaris)
RHEA:30299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate
RHEA:30299	skos:prefLabel	"DNA oxidative demethylase"
RHEA:30299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA oxidative demethylase"
RHEA:30299	skos:altLabel	"alkylated DNA repair protein"
RHEA:12700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dGMP <=> ADP + dGDP
REACT:R-XTR-909720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN alpha/beta binds to IFNAR2 (Xenopus tropicalis)
RHEA:32749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine(out) => ethanolamine(in)
REACT:R-DRE-4551648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO1 (Danio rerio)
REACT:R-HSA-5250979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botG:SYT1:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
REACT:R-MMU-5693153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1K dephosphorylates p-BCKDH (Mus musculus)
REACT:R-SSC-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Sus scrofa)
REACT:R-SSC-70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Sus scrofa)
REACT:R-XTR-2176445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD2 (Xenopus tropicalis)
REACT:R-CEL-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Caenorhabditis elegans)
RHEA:27395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2
RHEA:15143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin] => 4-methylphenol + H2O + 4 oxidized [azurin]
RHEA:69687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein 7-O-beta-D-glucoside + H2O = beta-D-glucose + genistein
RHEA:10946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + pseudouridine => H2O + psi-UMP
REACT:R-DRE-8854044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Danio rerio)
RHEA:25494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-beta-phellandrene + diphosphate => (2E)-geranyl diphosphate
REACT:R-BTA-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Bos taurus)
RHEA:13174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + phosphonate => H(+) + NADH + phosphate
REACT:R-SSC-5618331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC6 deacetylates microtubules (Sus scrofa)
REACT:R-PFA-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Plasmodium falciparum)
REACT:R-DME-2022851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfer GlcNAc to the heparan chain (Drosophila melanogaster)
RHEA:45403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-8937419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBR3 reduces DOX to DOXOL (Homo sapiens)
REACT:R-DME-210646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)
REACT:R-HSA-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Homo sapiens)
RHEA:34746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine 1-phosphate <=> 13-methyltetradecanal + phosphoethanolamine
RHEA:24454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine => L-glutamyl-[protein] + S-adenosyl-L-methionine
RHEA:39916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycerol + phosphate
RHEA:18894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP
REACT:R-DRE-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Danio rerio)
REACT:R-CFA-69144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 (Canis familiaris)
REACT:R-RNO-5638157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)
GO:0043167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion binding
GO:0043167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	atom binding
REACT:R-HSA-9683765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)
REACT:R-HSA-1236948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antigen processing by cathepsin S in endosoytic vesicle (Homo sapiens)
REACT:R-PFA-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Plasmodium falciparum)
REACT:R-RNO-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Rattus norvegicus)
RHEA:68170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-977071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Homo sapiens)
REACT:R-SCE-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Saccharomyces cerevisiae)
REACT:R-HSA-5423647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2A13 oxidises AFM1 to AFM1E (Homo sapiens)
REACT:R-SCE-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Saccharomyces cerevisiae)
REACT:R-HSA-446372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  PARVA with TESK1 (Homo sapiens)
REACT:R-PFA-5252079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Plasmodium falciparum)
RHEA:47066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:0043759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched chain acyl CoA synthetase (ADP-forming) activity
GO:0043759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoate + ATP + CoA = 2-methylbutanoyl-CoA + AMP + diphosphate
GO:0043759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain acyl-CoA synthetase (ADP-forming) activity
GO:0043759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain acyl CoA synthetase (ADP-forming) activity
GO:0043759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched chain acyl-CoA synthetase (ADP-forming) activity
GO:0043759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylbutanoate-CoA ligase activity
RHEA:34286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-tyrosine + O2 <=> 2 L-dopa
REACT:R-HSA-8853915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX binds the TP53 gene promoter (Homo sapiens)
RHEA:62343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide C + FADH2
REACT:R-GGA-3878123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of SAHF formation (Gallus gallus)
REACT:R-MMU-5340214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB binds O2 (Mus musculus)
REACT:R-PFA-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Plasmodium falciparum)
RHEA:21680	skos:prefLabel	"hydroxyphytanate oxidase"
RHEA:21680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyphytanate oxidase"
RHEA:21680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2
REACT:R-SCE-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Saccharomyces cerevisiae)
RHEA:20064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + a ribonucleoside 5'-triphosphate <=> a ribonucleoside 5'-diphosphate + dCMP + H(+)
REACT:R-GGA-8854222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D3 associates with RAB5 (Gallus gallus)
RHEA:43035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-D-alanine <=> 2-aminoprop-2-enoate + chloride + H(+)
RHEA:18587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate => D-glyceraldehyde 3-phosphate
RHEA:30589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinone-8 + dimethyl sulfide + H2O => 2-demethylmenaquinol-8 + dimethyl sulfoxide
RHEA:50503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]
REACT:R-BTA-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Bos taurus)
REACT:R-XTR-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Xenopus tropicalis)
REACT:R-CFA-6814764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasma membrane resorption (Canis familiaris)
REACT:R-SCE-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Saccharomyces cerevisiae)
RHEA:71365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in) => 17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out)
REACT:R-MMU-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Mus musculus)
RHEA:48700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol
RHEA:44265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA
RHEA:28137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hesperidin + H2O <=> (2S)-hesperetin + rutinose
REACT:R-MMU-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Mus musculus)
REACT:R-HSA-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-DRE-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Danio rerio)
RHEA:37444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
REACT:R-XTR-173705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b binds C6 (Xenopus tropicalis)
REACT:R-GGA-212269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Gallus gallus)
REACT:R-HSA-5692764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 binds CCND3 (Homo sapiens)
REACT:R-XTR-1470010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs (Xenopus tropicalis)
GO:0036400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sNPF receptor activity
GO:0036400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	short neuropeptide F receptor activity
REACT:R-MMU-421416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proglucagon translocates from the ER Lumen to secretory granules (Mus musculus)
REACT:R-BTA-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Bos taurus)
RHEA:20364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Homo sapiens)
RHEA:19216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an S-substituted L-cysteine <=> an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)
RHEA:41462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a sphingomyelin => 1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine
RHEA:50459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H3 <=> prostaglandin D3
REACT:R-HSA-5250986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botG HC:LC binds SYT1 and GT1b on the target cell surface (Homo sapiens)
RHEA:25078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-isopropyl-3-oxosuccinate + H(+) = 4-methyl-2-oxopentanoate + CO2
RHEA:65377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine
RHEA:61264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanine + O2 = H2O2 + NH4(+) + pyruvate
REACT:R-DRE-9012036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)
RHEA:26117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + epi-cedrol => (2E,6E)-farnesyl diphosphate + H2O
RHEA:70755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
RHEA:17719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP
REACT:R-CFA-451561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO binds polyubiquitinated IRAK1 (Canis familiaris)
RHEA:60207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate
RHEA:72199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + 2 H(+)(out) = Ca(2+)(out) + 2 H(+)(in)
RHEA:30476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oroxylin A 7-O-beta-D-glucuronate => D-glucuronate + H(+) + oroxylin A
RHEA:35007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fucose(in) = D-fucose(out)
RHEA:63489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-phenanthroquinone + H(+) + NADPH => NADP(+) + phenanthrene-9,10-diol
REACT:R-BTA-187035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-beta-NGF and mature beta-NGF are secreted (Bos taurus)
RHEA:55643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)
REACT:R-RNO-9796379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)
REACT:R-BTA-392295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma recruits PI3K gamma (Bos taurus)
REACT:R-CEL-1251997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ERBB4m80 by gamma-scretase complex (Caenorhabditis elegans)
REACT:R-GGA-374686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 interaction with Integrins (Gallus gallus)
RHEA:33598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine
REACT:R-SSC-5159250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF7IP binds SETDB1 (Sus scrofa)
REACT:R-MMU-373813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR2 binds ligands CXCL1 to 7 (Mus musculus)
RHEA:44240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol
REACT:R-BTA-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Bos taurus)
REACT:R-DME-75825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of Cyclin D1 (Drosophila melanogaster)
REACT:R-XTR-3788725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C complex binds EHMT1:EHMT2 (Xenopus tropicalis)
REACT:R-CFA-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Canis familiaris)
REACT:R-MMU-5658438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRED dimer binds NF1 (Mus musculus)
REACT:R-DME-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Drosophila melanogaster)
REACT:R-CEL-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Caenorhabditis elegans)
REACT:R-BTA-5625774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Bos taurus)
REACT:R-DRE-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Danio rerio)
REACT:R-BTA-166792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C2 into C2a and C2b (Bos taurus)
REACT:R-RNO-8944214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type I (Rattus norvegicus)
RHEA:60615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octanoyl-sn-glycero-3-phosphocholine <=> 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline
RHEA:37670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP
REACT:R-RNO-8855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR:DAB1 binds SH3KBP1 (Rattus norvegicus)
GO:0102859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming)
EC:3.6.1.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(+) diphosphatase"
EC:3.6.1.22	skos:altLabel	"nicotinamide adenine dinucleotide pyrophosphatase"
EC:3.6.1.22	skos:prefLabel	"NAD(+) diphosphatase"
EC:3.6.1.22	skos:altLabel	"NADH pyrophosphatase"
EC:3.6.1.22	skos:altLabel	"NADP pyrophosphatase"
REACT:R-HSA-216064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha8beta1 with Tenascin-C (Homo sapiens)
REACT:R-SSC-1676005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Sus scrofa)
RHEA:68699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SSC-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Sus scrofa)
REACT:R-MMU-193653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF homodimer binds to p75NTR (Mus musculus)
REACT:R-XTR-445084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by SRC (Xenopus tropicalis)
REACT:R-GGA-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Gallus gallus)
REACT:R-GGA-8863973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of ERC and phagosome (Gallus gallus)
RHEA:70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(in) + L-ornithine(out) => L-lysine(out) + L-ornithine(in)
REACT:R-CFA-2029460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates LIMK1 (Canis familiaris)
RHEA:42717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate
REACT:R-HSA-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Homo sapiens)
RHEA:36341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine
REACT:R-HSA-3076881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCTN translocates to extracellular region (Homo sapiens)
REACT:R-SPO-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Schizosaccharomyces pombe)
REACT:R-HSA-1676020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Homo sapiens)
REACT:R-XTR-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Xenopus tropicalis)
RHEA:27404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxychromene-2-carboxylate <=> (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate
RHEA:27705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galacturonate <=> keto-D-tagaturonate
REACT:R-HSA-4085027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)
RHEA:54708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-SCE-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Saccharomyces cerevisiae)
REACT:R-SPO-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Schizosaccharomyces pombe)
REACT:R-BTA-429732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Bos taurus)
REACT:R-DME-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)
REACT:R-RNO-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Rattus norvegicus)
RHEA:66104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine
RHEA:21324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"superoxide reductase"
RHEA:21324	skos:prefLabel	"superoxide reductase"
RHEA:21324	skos:altLabel	"desulfoferrodoxin"
RHEA:21324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + reduced [rubredoxin] + superoxide = H2O2 + oxidized [rubredoxin]
RHEA:21324	skos:altLabel	"neelaredoxin"
RHEA:59629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(4-aminobutanoyl)-L-arginine => 4-aminobutanoate + L-arginine
RHEA:51143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate
REACT:R-MMU-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Mus musculus)
REACT:R-CEL-8875531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS4 (Caenorhabditis elegans)
REACT:R-CFA-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Canis familiaris)
GO:0102449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 3-O-methyltransferase activity
GO:0071794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAP-Gly domain binding
REACT:R-BTA-8950387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX binds EBI3 (Bos taurus)
REACT:R-BTA-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Bos taurus)
REACT:R-DME-1638032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Drosophila melanogaster)
REACT:R-CFA-2730889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)
GO:0102938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orcinol O-methyltransferase activity
REACT:R-RNO-6805109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates TP53 (Rattus norvegicus)
REACT:R-SSC-5655142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 binds POLH (Sus scrofa)
REACT:R-MMU-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Mus musculus)
GO:0005385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
GO:0005385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc, cadmium uptake permease activity
GO:0005385	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	zinc, iron permease activity
GO:0005385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc ion transmembrane transporter activity
GO:0005385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalt, zinc uptake permease activity
RHEA:38450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O <=> 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose
RHEA:13107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + phosphate => glycerol 2-phosphate + H2O
REACT:R-DME-3640874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-RibC-AXIN is degraded by the proteasome (Drosophila melanogaster)
RHEA:45291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 <=> 2-glyceryl-prostaglandin G2
REACT:R-SSC-1482695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Sus scrofa)
RHEA:69234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => (Z)-3-hydroxypropyl glucosinolate + H2O
RHEA:58704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin hemiaminal = rifampicin ortho-naphthoquinone carboxamide
REACT:R-DME-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Drosophila melanogaster)
REACT:R-DME-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-HSA-3322971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MUT does not isomerise L-MM-CoA to SUCC-CoA (Homo sapiens)
RHEA:53789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholoyl-CoA + beta-muricholate => allodeoxycholate + beta-muricholoyl-CoA
REACT:R-SSC-9667569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,2 bind AVPR antagonists (Sus scrofa)
REACT:R-HSA-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Homo sapiens)
REACT:R-SSC-9710101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP4, CASP5 cleave GSDMD (Sus scrofa)
RHEA:59574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + L-histidine => H2O + L-homocarnosine
REACT:R-HSA-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
REACT:R-BTA-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Bos taurus)
REACT:R-CFA-983427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of peptide bound class I MHC on cell surface (Canis familiaris)
REACT:R-MMU-5334794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABPs bind LCFAs (Mus musculus)
EC:3.4.21.67	skos:altLabel	"E.coli cytoplasmic proteinase"
EC:3.4.21.67	skos:prefLabel	"endopeptidase So"
EC:3.4.21.67	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endopeptidase So"
REACT:R-HSA-8985485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 and RB1 bind the BGLAP gene promoter (Homo sapiens)
REACT:R-XTR-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Xenopus tropicalis)
RHEA:26334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin
RHEA:58646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienamide + glyoxylate => N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine
GO:0015459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium channel gating activity
GO:0015459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium channel regulator activity
REACT:R-MMU-8863973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of ERC and phagosome (Mus musculus)
REACT:R-DME-5433067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Drosophila melanogaster)
REACT:R-XTR-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Xenopus tropicalis)
RHEA:48163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)
REACT:R-DRE-192123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates CHOL (Danio rerio)
REACT:R-RNO-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Rattus norvegicus)
REACT:R-BTA-2730862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of LYN kinase (Bos taurus)
RHEA:13133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + di-trans,poly-cis-dolichol = a dolichyl phosphate + CDP + H(+)
RHEA:13133	skos:prefLabel	"dolichol kinase"
RHEA:13133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichol kinase"
REACT:R-HSA-264435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the COP1-p53 complex (Homo sapiens)
RHEA:42548	skos:altLabel	"23S RNA Psi(746) synthase"
RHEA:42548	skos:prefLabel	"23S rRNA pseudouridine(746) synthase"
RHEA:42548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA
RHEA:42548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA pseudouridine(746) synthase"
GO:0070063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase binding
RHEA:39666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:63100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ilicicolin C + NADPH + O2 = ascochlorin + 2 H2O + NADP(+)
RHEA:25348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tyrosyl-tRNA(Tyr) + H2O => D-tyrosine + tRNA(Tyr)
RHEA:12034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+) => a 3-(acyloxy)acyl derivative of bacterial toxin + H2O
RHEA:65206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate + CoA + H(+) => (3R)-3-hydroxybutanoyl-CoA + H2O
REACT:R-RNO-5694410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMED2:TMED10 tetramer binds GPI anchored proteins (Rattus norvegicus)
RHEA:42912	skos:prefLabel	"23S rRNA (cytosine(1962)-C(5))-methyltransferase"
RHEA:42912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (cytosine(1962)-C(5))-methyltransferase"
RHEA:42912	skos:altLabel	"rRNA large subunit methyltransferase I"
REACT:R-BTA-8851804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET recruits GRB2-1:SOS1 (Bos taurus)
REACT:R-HSA-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)
RHEA:70299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-dehydroascorbate = 2,3-dioxo-L-gulonate
RHEA:50020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)
REACT:R-RNO-8871194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
REACT:R-BTA-5626981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Bos taurus)
RHEA:38069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA
GO:1990238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dsDNA-specific endodeoxyribonuclease activity
GO:1990238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded DNA endodeoxyribonuclease activity
RHEA:72120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + glycine betaine(out) => (R)-carnitine(out) + glycine betaine(in)
REACT:R-GGA-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Gallus gallus)
REACT:R-RNO-175987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from AdoMet to PY (Rattus norvegicus)
GO:0018524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetophenone carboxylase activity
GO:0034824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citronellyl-CoA dehydrogenase activity
REACT:R-GGA-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Gallus gallus)
RHEA:10779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH
REACT:R-DME-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Drosophila melanogaster)
REACT:R-HSA-6785565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins (Homo sapiens)
REACT:R-XTR-5672843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1S1 (PRAS40) binds mTORC1 (Xenopus tropicalis)
RHEA:50721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + methanesulfinate + O2 => FMN + H(+) + H2O + methanesulfonate
RHEA:15586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 4 A => 4 AH2 + all-trans-lycopene
REACT:R-HSA-9648880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer (Homo sapiens)
RHEA:54356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"branched-chain-2-oxoacid decarboxylase"
RHEA:54356	skos:altLabel	"(3S)-3-methyl-2-oxopentanoate carboxy-lyase"
RHEA:54356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + H(+) = 2-methylpropanal + CO2
RHEA:54356	skos:prefLabel	"branched-chain-2-oxoacid decarboxylase"
RHEA:62043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(octanoyl)-sphing-4-enine-1-phosphate <=> N-octanoylsphing-4-enine + phosphate
REACT:R-CFA-5696534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 deubiquitinates TAK1:TAB1 (Canis familiaris)
REACT:R-HSA-5210935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves ANTXR1-bound pagA to yield pagA(197-794) (Homo sapiens)
REACT:R-HSA-5654571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS3 (Homo sapiens)
REACT:R-HSA-9650858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Meglitinides bind ABCC8 (Homo sapiens)
RHEA:31307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:31307	skos:altLabel	"Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol alpha-1->3-glucosyltransferase"
RHEA:31307	skos:prefLabel	"dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase"
RHEA:31307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase"
RHEA:40252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-methylrhodomycin D + H2O => 10-carboxy-13-deoxydaunorubicin + H(+) + methanol
RHEA:36186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline <=> a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-XTR-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Xenopus tropicalis)
RHEA:42238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA
REACT:R-HSA-2730836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of BCL10:MALT1 with CARMA1 to form CBM complex (Homo sapiens)
REACT:R-MMU-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Mus musculus)
REACT:R-HSA-437230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-FGFR cis-heterodimerization (Homo sapiens)
RHEA:27853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + phenylacetyl-CoA <=> CoA + H(+) + phenylacetylglycine
REACT:R-HSA-1222363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MsrA/B reduces peptide-methionine S/R-sulfoxides (Homo sapiens)
REACT:R-SSC-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Sus scrofa)
REACT:R-MMU-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Mus musculus)
RHEA:35280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hexadecanoyl-CoA => 3-oxooctadecanoyl-CoA + CoA
RHEA:23552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methyl-1,2-propanediol dehydrogenase"
RHEA:23552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropane-1,2-diol + NAD(+) = 2-hydroxy-2-methylpropanal + H(+) + NADH
RHEA:23552	skos:prefLabel	"2-methyl-1,2-propanediol dehydrogenase"
RHEA:12243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)
GO:0036429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcobinamide kinase (ATP-specific) activity
REACT:R-HSA-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Homo sapiens)
REACT:R-SPO-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Schizosaccharomyces pombe)
RHEA:65822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
EC:3.2.1.150	skos:prefLabel	"oligoxyloglucan reducing-end-specific cellobiohydrolase"
EC:3.2.1.150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligoxyloglucan reducing-end-specific cellobiohydrolase"
REACT:R-MMU-177931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)
RHEA:52929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-GMP + 2 H2O => 2 GMP + 2 H(+)
REACT:R-SPO-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Schizosaccharomyces pombe)
REACT:R-GGA-5654709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
RHEA:17358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 2 R'C(R)SH => H2O2 + R'C(R)S-S(R)CR'
REACT:R-SSC-193064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3-like proteins reducde ANDST to TEST (Sus scrofa)
REACT:R-SSC-8852522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 dimer:MST1R dimer binds MST1R dimer (Sus scrofa)
RHEA:37324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-methionine + H2O => glycine + L-methionine
RHEA:71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanine(out) + Na(+)(out) => H(+)(out) + L-alanine(in) + Na(+)(in)
REACT:R-HSA-879201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bcl-2 and Bcl-XL bind NLRP1 (Homo sapiens)
REACT:R-DME-964759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alternative endo-mannosidase I route (Drosophila melanogaster)
REACT:R-SCE-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Saccharomyces cerevisiae)
RHEA:48912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1a = CMP + ganglioside GT1a + H(+)
RHEA:22824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil
REACT:R-RNO-9709317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to free ferrohemoglobin (Rattus norvegicus)
GO:0018480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity
GO:0018480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity
GO:0018480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxymethylhydroxymuconic semialdehyde dehydrogenase activity
REACT:R-HSA-5687465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds RBBP8 (Homo sapiens)
REACT:R-SSC-9018863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Sus scrofa)
REACT:R-GGA-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Gallus gallus)
RHEA:43161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine
REACT:R-CEL-1247922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCT transforms gGluCys to OPRO (Caenorhabditis elegans)
REACT:R-SSC-9645501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Sus scrofa)
GO:0102338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-lignoceronyl-CoA synthase activity
REACT:R-HSA-2203516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-1-Microglobulin is cleaved (Homo sapiens)
REACT:R-SSC-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-DRE-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Danio rerio)
REACT:R-XTR-9732527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds rosiglitazone (Xenopus tropicalis)
RHEA:56497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:19833	skos:altLabel	"Formyl-FH(4) hydrolase"
RHEA:19833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)
RHEA:19833	skos:prefLabel	"formyltetrahydrofolate deformylase"
RHEA:19833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formyltetrahydrofolate deformylase"
RHEA:19833	skos:altLabel	"Formyltetrahydrofolate hydrolase"
REACT:R-BTA-5666088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP recruits DAIPH2-3 to endosomes (Bos taurus)
REACT:R-XTR-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Xenopus tropicalis)
REACT:R-XTR-1475414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Xenopus tropicalis)
REACT:R-RNO-193997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B1 oxidises 11DCORT (Rattus norvegicus)
RHEA:62655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1
RHEA:26235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol => (2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:58055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + acetyl-CoA <=> (2-acetamidoethyl)phosphonate + CoA + H(+)
RHEA:71765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + citrate(out) => 2-oxoglutarate(out) + citrate(in)
RHEA:31616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine => dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine
GO:0017125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidyl transferase activity
GO:0017125	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	deoxycytidyl transferase activity, template-dependent
GO:0017125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Homo sapiens)
REACT:R-SSC-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Sus scrofa)
GO:0102116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laurate hydroxylase activity
REACT:R-SPO-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Schizosaccharomyces pombe)
REACT:R-BTA-453104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
RHEA:30293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2
REACT:R-CFA-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Canis familiaris)
REACT:R-SSC-975185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Sus scrofa)
RHEA:67580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + tauro-alpha-muricholate = adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate
RHEA:29687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltoheptaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltohexaose
RHEA:39270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)
REACT:R-CFA-189384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)
REACT:R-CFA-376200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A10-mediated uptake of small neutral amino acids (Canis familiaris)
GO:0047303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine-oxalacetate aminotransferase activity
GO:0047303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine-oxaloacetate transaminase activity
GO:0047303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine--oxaloacetate aminotransferase activity
GO:0047303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine-oxaloacetate aminotransferase activity
GO:0047303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine:oxaloacetate aminotransferase activity
REACT:R-XTR-174447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation on the C-strand of the telomere (Xenopus tropicalis)
REACT:R-DRE-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Danio rerio)
RHEA:55076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + H(+) = 3-methylsulfanylpropanal + CO2
REACT:R-SSC-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Sus scrofa)
GO:0034820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,9-DSHA hydrolase activity
RHEA:60302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine
GO:0052688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity
GO:0052688	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity
RHEA:48969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 => [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O
RHEA:67988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-glutamine = N-acetyl-D-glutamine
REACT:R-MMU-2213244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides (Mus musculus)
RHEA:46235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:30763	skos:prefLabel	"valine dehydrogenase (NAD(+))"
RHEA:30763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valine dehydrogenase (NAD(+))"
RHEA:30763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)
RHEA:54415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-5beta-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH
REACT:R-GGA-1250357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds P-ERBB4 isoform dimers (Gallus gallus)
REACT:R-DRE-8987104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Danio rerio)
RHEA:17413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:51022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => a primary alcohol + 2 Fe(III)-[cytochrome c]
RHEA:21948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formamide + H2O = formate + NH4(+)
RHEA:21948	skos:altLabel	"Formamide amidohydrolase"
RHEA:21948	skos:prefLabel	"formamidase"
RHEA:21948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formamidase"
REACT:R-BTA-5685318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex formation (Bos taurus)
REACT:R-RNO-5632649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds GAS1 and PTCH (Rattus norvegicus)
REACT:R-SSC-2168079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL (GWL) phosphorylates ARPP19 (Sus scrofa)
REACT:R-CEL-5669158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF2 binds PAK1 (Caenorhabditis elegans)
REACT:R-HSA-5602050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP26C1 does not 4-hydroxylate 9cRA (Homo sapiens)
GO:0015105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite transmembrane transporter activity
EC:1.16.1.9	skos:prefLabel	"ferric-chelate reductase (NADPH)"
EC:1.16.1.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferric-chelate reductase (NADPH)"
EC:1.16.1.9	skos:altLabel	"ferric chelate reductase"
EC:1.16.1.9	skos:altLabel	"NADPH:Fe(3+)-EDTA reductase"
EC:1.16.1.9	skos:altLabel	"iron chelate reductase"
REACT:R-HSA-4086088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO1 (Homo sapiens)
RHEA:11889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + NADP(+) => a carboxylate + 2 H(+) + NADPH
RHEA:59129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate
REACT:R-BTA-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Bos taurus)
RHEA:60999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-leucine + O2 <=> 4-methyl-2-oxopentanoate + H2O2 + NH4(+)
REACT:R-SSC-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Sus scrofa)
REACT:R-XTR-1295540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Xenopus tropicalis)
EC:3.4.24.52	skos:prefLabel	"trimerelysin I"
EC:3.4.24.52	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trimerelysin I"
EC:3.4.24.52	skos:altLabel	"Trimeresurus metalloendopeptidase I"
EC:3.4.24.52	skos:altLabel	"hemorrhagic proteinase HR1a"
REACT:R-RNO-5623525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo-carrying vesicles bud from the TGN (Rattus norvegicus)
REACT:R-DDI-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Dictyostelium discoideum)
GO:0047788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity
GO:0047788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coumarate reductase activity
GO:0047788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-coumarate reductase activity
GO:0047788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	melilotate dehydrogenase activity
REACT:R-SSC-8983378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Sus scrofa)
REACT:R-RNO-191830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP nuclear import and release (Rattus norvegicus)
REACT:R-BTA-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Bos taurus)
RHEA:35526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-ethylmaleimide + NADPH <=> N-ethylsuccinimide + NADP(+)
RHEA:55392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine
EC:2.4.1.330	skos:altLabel	"UGT94E5"
EC:2.4.1.330	skos:prefLabel	"beta-D-glucosyl crocetin beta-1,6-glucosyltransferase"
EC:2.4.1.330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-D-glucosyl crocetin beta-1,6-glucosyltransferase"
RHEA:14330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O-phospho-L-serine => 3-phosphooxypyruvate + L-glutamate
RHEA:36767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine
REACT:R-BTA-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Bos taurus)
REACT:R-SSC-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Sus scrofa)
REACT:R-MMU-9632918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Mus musculus)
RHEA:53724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate
RHEA:37871	skos:altLabel	"2-heptyl-3,4-dihydroxyquinoline synthase"
RHEA:37871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-heptyl-3-hydroxy-4(1H)-quinolone synthase"
RHEA:37871	skos:prefLabel	"2-heptyl-3-hydroxy-4(1H)-quinolone synthase"
RHEA:37871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)
RHEA:67335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinal + H2O + NAD(+) <=> 13-cis-retinoate + 2 H(+) + NADH
REACT:R-BTA-8874685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds MET (Bos taurus)
REACT:R-CFA-373745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK1 homophillic interaction (Canis familiaris)
REACT:R-DDI-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Dictyostelium discoideum)
REACT:R-SSC-209944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D binds GC (Sus scrofa)
REACT:R-CEL-4341070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PPARA with SUMO1 (Caenorhabditis elegans)
REACT:R-SCE-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Saccharomyces cerevisiae)
GO:0019806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromoperoxidase activity
GO:0019806	skos:altLabel	"eosinophil peroxidase"
GO:0019806	skos:prefLabel	"bromide peroxidase"
GO:0019806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bromide peroxidase"
GO:0019806	skos:altLabel	"bromoperoxidase"
GO:0019806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide peroxidase activity
REACT:R-DME-9695890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Drosophila melanogaster)
REACT:R-MMU-199917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates CREB at Serine 133 (Mus musculus)
GO:0005017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF receptor activity
GO:0005017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFR activity
GO:0005017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	platelet-derived growth factor-activated receptor activity
GO:0005017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	platelet-derived growth factor receptor activity
GO:0005017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-activated receptor activity
REACT:R-HSA-2065966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds the TM7SF2 promoter (Homo sapiens)
RHEA:20370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H2O + O2 => glycine betaine + H(+) + H2O2
RHEA:58346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + lithocholate => beta-D-glucosyl-(1->3)-O-lithocholate + H2O
REACT:R-CEL-1638104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Caenorhabditis elegans)
REACT:R-SCE-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Saccharomyces cerevisiae)
REACT:R-CEL-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Caenorhabditis elegans)
RHEA:55303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-CEL-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Caenorhabditis elegans)
REACT:R-GGA-187688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Gallus gallus)
REACT:R-XTR-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Xenopus tropicalis)
REACT:R-HSA-1358789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Self-ubiquitination of RNF41 (Homo sapiens)
GO:0047141	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:cystine oxidoreductase
GO:0047141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-cystine transhydrogenase activity
GO:0047141	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent GSH-cystine transhydrogenase
GO:0047141	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GSH-cystine transhydrogenase
REACT:R-RNO-1602446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Rattus norvegicus)
REACT:R-DME-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Drosophila melanogaster)
REACT:R-XTR-9611277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds P2RY12 antagonists (Xenopus tropicalis)
RHEA:27689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GDP <=> ADP + GTP
REACT:R-CEL-9690439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)
RHEA:23562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)alamin 5'-phosphate + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate
REACT:R-DRE-9603420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 promotes SRC autophosphorylation (Danio rerio)
RHEA:71544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethyl-dUMP in DNA + ATP => 5-phosphomethyl-dUMP in DNA + ADP + H(+)
REACT:R-RNO-2130349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Generation of CLIP from lip10 (Rattus norvegicus)
RHEA:16083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-S-methyl-1-thioglycerate + phosphate => (2R)-S-methyl-3-phospho-1-thioglycerate + H2O
REACT:R-SSC-2022368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-42) (Sus scrofa)
REACT:R-RNO-378952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin is a heterodimer (Rattus norvegicus)
REACT:R-RNO-8940998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36RN, IL1F10 bind IL1RL2 (Rattus norvegicus)
RHEA:14984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADPH
REACT:R-RNO-5654562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Rattus norvegicus)
RHEA:26011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)
REACT:R-MMU-187688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Mus musculus)
REACT:R-HSA-9620788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 binds RBL2 gene (Homo sapiens)
REACT:R-HSA-5635848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind PTCH1 gene (Homo sapiens)
REACT:R-CFA-9624668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDKN1A (p21) (Canis familiaris)
REACT:R-CFA-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Canis familiaris)
REACT:R-RNO-909721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ISGF3 complex to nucleus (Rattus norvegicus)
GO:0005548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipid transporter activity
REACT:R-BTA-8853734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Bos taurus)
REACT:R-HSA-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)
REACT:R-RNO-5333678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPNEs bind PL (Rattus norvegicus)
REACT:R-GGA-8849900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs1-3 bind each other in cis interactions (Gallus gallus)
REACT:R-HSA-166219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion picks up a proton (Homo sapiens)
REACT:R-DRE-5675431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates RAF1 (Danio rerio)
REACT:R-MMU-110355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MUTYH glycosylase by APEX1 at the AP site (Mus musculus)
RHEA:11108	skos:prefLabel	"chondroitin 6-sulfotransferase"
RHEA:11108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)
RHEA:11108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chondroitin 6-sulfotransferase"
REACT:R-XTR-5654514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds FGFR1c (Xenopus tropicalis)
REACT:R-DDI-5333678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPNEs bind PL (Dictyostelium discoideum)
REACT:R-MMU-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Mus musculus)
REACT:R-SPO-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Schizosaccharomyces pombe)
REACT:R-SSC-1181153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Sus scrofa)
REACT:R-DME-391936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP1 receptor can bind PGE2 (Drosophila melanogaster)
RHEA:49431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + phosphonoformate <=> CMP-5'-phosphonoformate + diphosphate
REACT:R-CFA-351987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A6-mediated uptake of taurine and beta-alanine (Canis familiaris)
REACT:R-BTA-9026405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Bos taurus)
GO:0102054	skos:prefLabel	"maleylpyruvate hydrolase"
GO:0102054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maleylpyruvate hydrolase"
GO:0102054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylpyruvate hydrolase activity
GO:0102054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-maleylpyruvate + H2O = H(+) + maleate + pyruvate
REACT:R-HSA-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Homo sapiens)
REACT:R-RNO-9611852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB3 bind ADR,NAd (Rattus norvegicus)
RHEA:10582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate
REACT:R-GGA-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Gallus gallus)
REACT:R-XTR-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Xenopus tropicalis)
REACT:R-XTR-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
RHEA:47615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP
RHEA:63223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine
RHEA:47001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-9012542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Canis familiaris)
REACT:R-DRE-5635842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3 phosphorylates GLI (Danio rerio)
REACT:R-HSA-392195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi activation by P2Y purinoceptor 12 (Homo sapiens)
REACT:R-DRE-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Danio rerio)
RHEA:24069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanone + H(+) + NADPH + O2 => H2O + hexano-6-lactone + NADP(+)
GO:0016034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-maleylacetoacetate = 4-fumarylacetoacetate
GO:0016034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maleylacetone isomerase activity
GO:0016034	skos:altLabel	"maleylacetone isomerase"
GO:0016034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maleylacetoacetic isomerase activity
GO:0016034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maleylacetone cis-trans-isomerase activity
GO:0016034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maleylacetoacetate isomerase"
GO:0016034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate isomerase activity
GO:0016034	skos:prefLabel	"maleylacetoacetate isomerase"
GO:0016034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-maleylacetoacetate cis-trans-isomerase activity
REACT:R-SPO-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Schizosaccharomyces pombe)
REACT:R-DRE-5610735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB binds ITCH (Danio rerio)
REACT:R-RNO-375302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules (Rattus norvegicus)
GO:0047354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-choline:sphingosine cholinephosphotransferase activity
GO:0047354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphocholine-sphingosine cholinephosphotransferase activity
GO:0047354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine choline phosphotransferase activity
GO:0047354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-choline-sphingosine cholinephosphotransferase activity
GO:0047354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylcholine-sphingosine transferase activity
GO:0047354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine cholinephosphotransferase activity
RHEA:34219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxymuconate-6-semialdehyde dehydrogenase"
RHEA:34219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH
RHEA:34219	skos:prefLabel	"2-hydroxymuconate-6-semialdehyde dehydrogenase"
RHEA:52630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + an L-alpha-amino acid => an N-fatty-acyl-L-alpha-amino acid + H2O
REACT:R-DRE-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Danio rerio)
REACT:R-SSC-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Sus scrofa)
RHEA:45106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitomycin A + S-adenosyl-L-homocysteine => 6-demethylmitomycin A + S-adenosyl-L-methionine
RHEA:19134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3,3',5-triiodo-L-thyronine => 3,5,3'-triiodothyropyruvate + L-glutamate
REACT:R-DRE-68918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK and DDK associate with the Mcm10:pre-replicative complex (Danio rerio)
REACT:R-GGA-9668023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to FVIII (Gallus gallus)
GO:0140343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylserine transfer activity
GO:0140343	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane phosphatidylserine carrier activity
RHEA:45241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA
REACT:R-SPO-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)
REACT:R-XTR-9761344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 binds IKBKG within IKK complex (Xenopus tropicalis)
RHEA:26394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 O2 => 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
RHEA:44146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(alpha)-acetyl-L-methionine => acetyl-CoA + L-methionine
REACT:R-SSC-9793988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates CFLAR at K351, K353 (Sus scrofa)
REACT:R-HSA-141423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the MCC complex to the APC/C complex (Homo sapiens)
REACT:R-DRE-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Danio rerio)
REACT:R-DDI-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-HSA-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)
GO:0042800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K4 methyltransferase activity
GO:0042800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3K4 methyltransferase activity
GO:0042800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-methyltransferase activity (H3-K4 specific)
GO:0042800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H3-K4 specific)
GO:0042800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-K4 specific)
GO:0042800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K4 methylase activity
GO:0042800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3 lysine 4-specific methyltransferase activity
REACT:R-BTA-8950778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dimerizes (Bos taurus)
GO:0052846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity
GO:0052846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
GO:0052846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,5-bispyrophosphate 2,3,4,6-tetrakisphosphate 1-pyrophosphatase activity
REACT:R-CEL-3858482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is recruited to the receptor (Caenorhabditis elegans)
GO:0052913	skos:prefLabel	"16S rRNA (guanine(966)-N(2))-methyltransferase"
GO:0052913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16S rRNA (guanine(966)-N(2))-methyltransferase activity
GO:0052913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (guanine(966)-N(2))-methyltransferase"
GO:0052913	skos:altLabel	"m(2)G966 methyltransferase"
GO:0052913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(966) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine
REACT:R-CFA-75083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Canis familiaris)
REACT:R-XTR-8954110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1:EPC1 binds the PRC2 complex (Xenopus tropicalis)
REACT:R-DME-451858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YKI binds to HPO homodimer (Drosophila melanogaster)
REACT:R-GGA-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Gallus gallus)
RHEA:30066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> H(+) + menaquinol-8 + S-adenosyl-L-homocysteine
REACT:R-CEL-8955844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBKS phosphorylates ribose to R5P (Caenorhabditis elegans)
RHEA:43623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NADP(+) <=> aminoacetaldehyde + CO2 + NADPH
REACT:R-CFA-5665748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds RHOC:GTP (Canis familiaris)
RHEA:21189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + deamido-NAD(+) + NH4(+) => AMP + diphosphate + H(+) + NAD(+)
REACT:R-HSA-5649658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves DHU from damaged DNA (Homo sapiens)
RHEA:36188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
REACT:R-GGA-9008054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RAPL1 (Gallus gallus)
RHEA:52167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-912727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds VAV (Xenopus tropicalis)
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	porter activity
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	electrochemical potential-driven transporter activity
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	multidrug endosomal transmembrane transporter activity
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ion-gradient-driven energizer activity
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secondary carrier-type facilitators
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	porters
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose/glucose (methylgalactoside) porter activity
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	active transporter
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coupled carrier
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heavy metal ion porter activity
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secondary active transmembrane transporter activity
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	energizer of outer membrane receptor-mediated transport activity
GO:0015291	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nitrite/nitrate porter activity
RHEA:64072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA = 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O
RHEA:31556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-amino-3-oxohexanoate + acetyl-CoA => (3S)-3-aminobutanoyl-CoA + acetoacetate
REACT:R-CFA-77608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of A1CF to stem-looped RNA (Canis familiaris)
REACT:R-HSA-5669097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA trimer binds TNFRSF1A,1B,14 (Homo sapiens)
REACT:R-CFA-5678315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Canis familiaris)
RHEA:19740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanoate + H2O <=> 4-aminobutanoate + L-glutamate
REACT:R-MMU-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)
GO:0004706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JUN kinase kinase kinase activity
GO:0004706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	JNK kinase kinase activity
GO:0004706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JNKKK
RHEA:30909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + CO2 + NADH => (S)-3-methyl-2-oxopentanoate + CoA + NAD(+)
RHEA:67978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-zeacarotene => all-trans-neurosporene
REACT:R-RNO-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)
RHEA:66393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + prostaglandin E1(in) => ADP + H(+) + phosphate + prostaglandin E1(out)
REACT:R-DRE-5658438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRED dimer binds NF1 (Danio rerio)
REACT:R-SSC-192061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP46A1 24-hydroxylates CHOL (Sus scrofa)
REACT:R-SSC-69144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)
REACT:R-GGA-202960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of C-IAP1 (Gallus gallus)
RHEA:36747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:36747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase"
RHEA:36747	skos:prefLabel	"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase"
RHEA:22232	skos:prefLabel	"Botryococcus squalene synthase"
RHEA:22232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + presqualene diphosphate = diphosphate + NADP(+) + squalene
RHEA:22232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Botryococcus squalene synthase"
REACT:R-HSA-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Homo sapiens)
REACT:R-XTR-139842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Syk tyrosine kinase (Xenopus tropicalis)
REACT:R-XTR-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)
RHEA:13530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalate => H2O + mesaconate
REACT:R-HSA-8944233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIX (Homo sapiens)
RHEA:21726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + NH4(+) => a nitrile + 2 H2O
RHEA:47375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + D-glucose <=> a quinol + D-glucono-1,5-lactone
REACT:R-DRE-8851011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 polyubiquitinates PTEN (Danio rerio)
RHEA:36335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + H2O + NAD(+) = D-glucarate + 2 H(+) + NADH
GO:0018486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-butanone oxidase activity
REACT:R-MMU-8940134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 binds FOLA (Mus musculus)
REACT:R-BTA-174120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Bos taurus)
REACT:R-RNO-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Rattus norvegicus)
REACT:R-GGA-212356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL-NICD coactivator complex (Gallus gallus)
REACT:R-CFA-8964599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Canis familiaris)
REACT:R-HSA-2179387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Homo sapiens)
REACT:R-HSA-167117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition (Homo sapiens)
RHEA:67251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H2O + NAD(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH
REACT:R-CFA-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Canis familiaris)
REACT:R-CFA-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Canis familiaris)
REACT:R-MMU-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Mus musculus)
RHEA:51207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-trans-leukotriene B4 + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH
RHEA:23144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylhexosamine 1-dehydrogenase"
RHEA:23144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-D-glucosamine + NAD(+) = 2 H(+) + N-acetyl-D-glucosaminate + NADH
RHEA:23144	skos:prefLabel	"N-acetylhexosamine 1-dehydrogenase"
RHEA:24386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-glutamate + NAD(+) => ATP + deamido-NAD(+) + H2O + L-glutamine
RHEA:37615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-CFA-5665802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Canis familiaris)
RHEA:70836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-glutamine(out) + Na(+)(out) => L-arginine(out) + L-glutamine(in) + Na(+)(in)
REACT:R-DME-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Drosophila melanogaster)
REACT:R-HSA-5682992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A,B bind H4K20Me2 (Homo sapiens)
REACT:R-DDI-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Dictyostelium discoideum)
EC:3.4.24.49	skos:prefLabel	"bothropasin"
EC:3.4.24.49	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bothropasin"
RHEA:65696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine
RHEA:30949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-epi-gamma-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:68168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]
RHEA:61805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-alanine => diphosphate + L-alanyl-5'-AMP
RHEA:57123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
RHEA:47376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-2029451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Sus scrofa)
REACT:R-CEL-6799203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Caenorhabditis elegans)
RHEA:24851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroshikimate <=> 3,4-dihydroxybenzoate + H2O
REACT:R-DME-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Drosophila melanogaster)
REACT:R-CFA-8956050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Canis familiaris)
RHEA:72643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine
REACT:R-CFA-9647643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds bacterial cardiolipin (Canis familiaris)
REACT:R-BTA-159783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)
REACT:R-DME-5694433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 binds PREB (Drosophila melanogaster)
REACT:R-GGA-416639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Gallus gallus)
RHEA:62167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O <=> D-glucosamine + N-acetyl-D-glucosamine
REACT:R-XTR-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Xenopus tropicalis)
REACT:R-GGA-8938853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 binds RUNX1 (Gallus gallus)
REACT:R-HSA-8866304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL binds lipids to form VLDL (Homo sapiens)
RHEA:36823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate
RHEA:36823	skos:altLabel	"AIP synthase"
RHEA:36823	skos:prefLabel	"archaetidylinositol phosphate synthase"
RHEA:36823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"archaetidylinositol phosphate synthase"
GO:0018591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl tertiary butyl ether 3-monooxygenase activity
GO:0018591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTBE 3-monooxygenase activity
REACT:R-MMU-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Mus musculus)
REACT:R-HSA-400228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMAL1 binds CLOCK,NPAS2 forming BMAL1:CLOCK,NPAS2 heterodimer (Homo sapiens)
REACT:R-SSC-8875659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Sus scrofa)
REACT:R-DRE-141316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Danio rerio)
REACT:R-MMU-432909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Plectin with Integrin beta 4 (Mus musculus)
RHEA:19692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnulose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate
REACT:R-DRE-373741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK2 homophillic interaction (Danio rerio)
REACT:R-MMU-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Mus musculus)
REACT:R-GGA-389756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT interacts and phosphorylates Cot (Gallus gallus)
REACT:R-HSA-5250972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
RHEA:63460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + GTP = (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)
REACT:R-CFA-3229089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Canis familiaris)
REACT:R-DME-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Drosophila melanogaster)
REACT:R-MMU-977629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of C2a/Bb by CR1 (Mus musculus)
REACT:R-DRE-5617182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates PLN (Danio rerio)
REACT:R-DRE-167433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta-gamma subunits rebind the alpha-GDP subunit (Danio rerio)
GO:0018463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexanoate dehydrogenase activity
GO:0018463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxyhexanoate:NAD+ oxidoreductase activity
REACT:R-DME-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Drosophila melanogaster)
REACT:R-DRE-209868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
REACT:R-SSC-8938231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds CREBBP (Sus scrofa)
REACT:R-GGA-904830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
GO:0045511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-25 binding
GO:0045511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-25 binding
RHEA:52092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)
REACT:R-HSA-1181355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)
REACT:R-XTR-1971491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Xenopus tropicalis)
RHEA:20245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate
RHEA:20245	skos:prefLabel	"streptomycin 3''-adenylyltransferase"
RHEA:20245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"streptomycin 3''-adenylyltransferase"
REACT:R-MMU-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Mus musculus)
RHEA:35658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP <=> 3',3'-c-di-AMP + 2 diphosphate
GO:0103107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	castasterone 23-O-glucosyltransferase activity
RHEA:57926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + premutilin => H2O + mutildienyl diphosphate
REACT:R-DME-3928640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs phosphorylate MLC (Drosophila melanogaster)
RHEA:62218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + phyllostine => isoepoxydon + NADP(+)
REACT:R-HSA-5601843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP17A1 does not 17-hydroxylate PREG (Homo sapiens)
RHEA:52710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + guanine => GMP + H2O
REACT:R-CEL-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Caenorhabditis elegans)
REACT:R-GGA-5682598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates HERC2 (Gallus gallus)
REACT:R-MMU-9614564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO4 (Mus musculus)
REACT:R-HSA-8985988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Homo sapiens)
REACT:R-MMU-8855375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dissociates from CSK (Mus musculus)
RHEA:32688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => diphosphate + tricyclene
REACT:R-XTR-9614271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ADGRG6 (Xenopus tropicalis)
RHEA:10159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:61241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-phenylalanine + O2 => 3-phenylpyruvate + H2O2 + NH4(+)
REACT:R-RNO-5617828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIP11:IFT20 dissociates (Rattus norvegicus)
RHEA:55849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA
REACT:R-PFA-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Plasmodium falciparum)
REACT:R-SSC-9026911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Sus scrofa)
RHEA:51449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-6805507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 binds AVEN (Gallus gallus)
REACT:R-HSA-9027562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA (Homo sapiens)
RHEA:61377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate
RHEA:25520	skos:altLabel	"pseudotropine tigloyltransferase"
RHEA:25520	skos:altLabel	"PAT"
RHEA:25520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + pseudotropine = CoA + H(+) + O-acylpseudotropine
RHEA:25520	skos:altLabel	"pseudotropine acetyltransferase"
RHEA:25520	skos:prefLabel	"pseudotropine acyltransferase"
RHEA:25520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudotropine acyltransferase"
RHEA:58741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + psi-UTP => diphosphate + H(+) + psi-UMP
GO:0030268	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity
GO:0030268	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity
GO:0030268	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydromethanopterin dehydrogenase activity
GO:0030268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydromethanopterin dehydrogenase activity
REACT:R-SSC-8866551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR binds components of the ERAD machinery for ubiquitination and degradation (Sus scrofa)
EC:1.14.13.210	skos:altLabel	"4-methyl-5-nitrocatechol oxygenase"
EC:1.14.13.210	skos:prefLabel	"4-methyl-5-nitrocatechol 5-monooxygenase"
EC:1.14.13.210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-methyl-5-nitrocatechol 5-monooxygenase"
EC:1.14.13.210	skos:altLabel	"MNC monooxygenase"
REACT:R-CEL-72143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lariat Formation and 5'-Splice Site Cleavage (Caenorhabditis elegans)
EC:2.4.1.47	skos:prefLabel	"N-acylsphingosine galactosyltransferase"
EC:2.4.1.47	skos:altLabel	"2-hydroxyacylsphingosine 1-beta-galactosyltransferase"
EC:2.4.1.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acylsphingosine galactosyltransferase"
REACT:R-RNO-6786166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)
RHEA:48680	skos:altLabel	"very-long-chain beta-ketoacyl-CoA reductase"
RHEA:48680	skos:altLabel	"very-long-chain 3-ketoacyl-CoA reductase"
RHEA:48680	skos:prefLabel	"very-long-chain 3-oxoacyl-CoA reductase"
RHEA:48680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"very-long-chain 3-oxoacyl-CoA reductase"
RHEA:48680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH
REACT:R-DRE-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Danio rerio)
GO:0080124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pheophytin pheophorbide hydrolase activity
GO:0080124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pheophytinase activity
RHEA:45600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)
RHEA:45600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)
RHEA:45600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-galactarolactone cycloisomerase"
RHEA:45600	skos:prefLabel	"D-galactarolactone cycloisomerase"
RHEA:70032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Dictyostelium discoideum)
REACT:R-XTR-2187401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)
REACT:R-RNO-205231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of KIT upon SCF binding (Rattus norvegicus)
REACT:R-SSC-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Sus scrofa)
RHEA:49038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-bursehernin + H(+) + S-adenosyl-L-homocysteine => (-)-pluviatolide + S-adenosyl-L-methionine
RHEA:37719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
REACT:R-BTA-8956568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the core TAL1 complex (Bos taurus)
RHEA:71259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in)
RHEA:66997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpentanoate + ATP + CoA => 2-methylpentanoyl-CoA + AMP + diphosphate
REACT:R-BTA-997237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B proteins bind JAK2 (Bos taurus)
GO:0015499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate transmembrane transporter activity
GO:0015499	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate uptake transmembrane transporter activity
GO:0015499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate uptake permease activity
GO:0015499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(in) = formate(out)
REACT:R-PFA-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-SSC-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Sus scrofa)
RHEA:67857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] => 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-170975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-FRS2 binds CRKL (Homo sapiens)
RHEA:47504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NADP(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
REACT:R-HSA-9031616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR binds ARC gene (Homo sapiens)
REACT:R-DDI-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)
REACT:R-DRE-2022065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPGs are secreted (Danio rerio)
RHEA:28334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + H2O = dAMP + diphosphate + H(+)
RHEA:23086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methyl-3-oxooct-6-enoyl-CoA + acetate => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA
REACT:R-CFA-114558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate Gq (Canis familiaris)
REACT:R-XTR-2243931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-lysinonorleucine cross-links (Xenopus tropicalis)
REACT:R-BTA-4641350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TOP2A with SUMO2,3 (Bos taurus)
REACT:R-BTA-9620456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sGC stimulators bind sGC:NO (Bos taurus)
REACT:R-SSC-912757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S585-IL3RB binds 14-3-3 proteins (Sus scrofa)
REACT:R-RNO-3215295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates MDM2 (Rattus norvegicus)
REACT:R-HSA-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)
REACT:R-CFA-9027633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Canis familiaris)
REACT:R-DRE-109700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT2 binds PIP3 (Danio rerio)
REACT:R-MMU-6809309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR6 binds MTMR9 (Mus musculus)
REACT:R-CFA-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Canis familiaris)
REACT:R-CFA-5602080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Canis familiaris)
GO:0004662	skos:prefLabel	"protein geranylgeranyltransferase type I"
GO:0004662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAAX-protein geranylgeranyltransferase activity
GO:0004662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type I protein geranyl-geranyltransferase activity
GO:0004662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTase-I activity
GO:0004662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein geranylgeranyltransferase type I
GO:0004662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTaseI activity
GO:0004662	skos:altLabel	"type I protein geranyl-geranyltransferase"
GO:0004662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein geranylgeranyltransferase type I"
GO:0004662	skos:altLabel	"GGTase-I"
GO:0004662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyltransferase type I activity
GO:0004662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
GO:0004662	skos:altLabel	"GGTaseI"
RHEA:70921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + dopamine(in) + Na(+)(in) => chloride(out) + dopamine(out) + Na(+)(out)
RHEA:56550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-SCE-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Saccharomyces cerevisiae)
RHEA:51901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine => acetate + spermidine
REACT:R-DME-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)
GO:0019911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of myelin sheath
RHEA:65053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trifluoromethyl)benzyl alcohol + NAD(+) => 4-(trifluoromethyl)benzaldehyde + H(+) + NADH
RHEA:55339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine <=> a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-203680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)
REACT:R-RNO-158800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Rattus norvegicus)
REACT:R-SCE-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)
REACT:R-DRE-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Danio rerio)
REACT:R-MMU-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Mus musculus)
RHEA:48317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b => a ganglioside GD1alpha + CMP + H(+)
REACT:R-MMU-165179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TSC1:TSC2 complex (Mus musculus)
RHEA:53537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate
RHEA:63376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:62149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + dTMP => dGDP + dTDP
RHEA:21409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-phenylalanine + NAD(+) => 3-phenylpyruvate + H(+) + NADH + NH4(+)
REACT:R-RNO-3769397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOST binds LRP5/6 (Rattus norvegicus)
REACT:R-RNO-5607720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p100:RELB binds active NIK:p-IKKA dimer (Rattus norvegicus)
REACT:R-GGA-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Gallus gallus)
REACT:R-XTR-9700156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK dimer binds IRS1 (Xenopus tropicalis)
REACT:R-CFA-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Canis familiaris)
REACT:R-CEL-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Caenorhabditis elegans)
REACT:R-MMU-8939801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
REACT:R-SCE-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Saccharomyces cerevisiae)
RHEA:55672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
RHEA:55672	skos:prefLabel	"poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase"
RHEA:55672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase"
REACT:R-DME-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Drosophila melanogaster)
REACT:R-HSA-847070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated TAK1 dissociates from the TLR3 receptor complex (Homo sapiens)
REACT:R-BTA-443986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor ACKR2 binds most inflammatory CC chemokines (Bos taurus)
REACT:R-MMU-6807064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces ZYMOL to ZYMSTNL (Mus musculus)
REACT:R-HSA-9661980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F8 variant is not secreted (Homo sapiens)
RHEA:68805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kojibiose => alpha-D-glucose + D-glucose
REACT:R-RNO-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)
RHEA:15921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactolipid galactosyltransferase"
RHEA:15921	skos:prefLabel	"galactolipid galactosyltransferase"
RHEA:15921	skos:altLabel	"DGDG synthase"
RHEA:15921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol
RHEA:15921	skos:altLabel	"galactolipid-galactolipid galactosyltransferase"
RHEA:15921	skos:altLabel	"digalactosyldiacylglycerol synthase"
RHEA:15921	skos:altLabel	"interlipid galactosyltransferase"
RHEA:15921	skos:altLabel	"GGGT"
REACT:R-DRE-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)
REACT:R-BTA-5610742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI1 (Bos taurus)
REACT:R-XTR-4754181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me2K5-histone H3 (Xenopus tropicalis)
REACT:R-RNO-9021306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds and inactivates C1r, C1s (Rattus norvegicus)
GO:0008961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
REACT:R-HSA-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Homo sapiens)
RHEA:28584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dUTP => ATP + dUDP
REACT:R-HSA-5696815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELAC2 cleaves the 3' end of pre-tRNA (Homo sapiens)
REACT:R-MMU-419002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Mus musculus)
RHEA:45469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate => (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate
RHEA:52537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + dGTP => AMP + dGDP + H(+)
GO:0047433	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain alpha-keto acid decarboxylase activity
GO:0047433	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)
GO:0047433	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain keto acid decarboxylase activity
GO:0047433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain-2-oxoacid decarboxylase activity
GO:0047433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO2
GO:0047433	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BCKA
GO:0047433	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain oxo acid decarboxylase activity
GO:0047433	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity
REACT:R-HSA-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Homo sapiens)
RHEA:64645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + propanoyl-CoA => butyl propanoate + CoA
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in)
GO:0048502	skos:altLabel	"thiamine transporting ATPase"
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin-transporting ATPase activity
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	thiamin pyrophosphate porter activity
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine-transporting ATPase activity
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type thiamine transporter activity
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine pyrophosphate-transporting ATPase activity
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine ABC transporter
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type thiamine transporter"
GO:0048502	skos:altLabel	"thiamine ABC transporter"
GO:0048502	skos:prefLabel	"ABC-type thiamine transporter"
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent thiamine transmembrane transporter activity
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin pyrophosphate ABC transporter
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPP transporting ATPase activity
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin pyrophosphate transporting ATPase activity
GO:0048502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled thiamine transmembrane transporter activity
REACT:R-XTR-159773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein S to protein S (Xenopus tropicalis)
REACT:R-CEL-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
REACT:R-RNO-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Rattus norvegicus)
RHEA:29055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + 2 H(+)(in) + H2 = a ubiquinol + 2 H(+)(out)
REACT:R-SCE-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Saccharomyces cerevisiae)
RHEA:36982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA
REACT:R-GGA-5324617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:FKBP4:PTGES3 binds HSF1 trimer (Gallus gallus)
REACT:R-HSA-5607004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds PRTN3:CD177 (Homo sapiens)
RHEA:38253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanyl octadecanoate => hexadecan-1-ol + octadecanoyl-CoA
REACT:R-HSA-165758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and inactivation of eEF2K by activated S6K1 (Homo sapiens)
RHEA:62627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutaredoxin]-dithiol + a hydroperoxide <=> [glutaredoxin]-disulfide + an alcohol + H2O
RHEA:34631	skos:altLabel	"vitamin D3 25-hydroxylase"
RHEA:34631	skos:altLabel	"5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase"
RHEA:34631	skos:altLabel	"sterol 26-hydroxylase"
RHEA:34631	skos:altLabel	"cytochrome P450 27A1'"
RHEA:34631	skos:altLabel	"cholesterol 27-hydroxylase"
RHEA:34631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholestanetriol 26-monooxygenase"
RHEA:34631	skos:altLabel	"5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase"
RHEA:34631	skos:altLabel	"sterol 27-hydroxylase"
RHEA:34631	skos:prefLabel	"cholestanetriol 26-monooxygenase"
RHEA:34631	skos:altLabel	"cholestanetriol 26-hydroxylase"
RHEA:34631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]
REACT:R-BTA-1676204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)
REACT:R-DME-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Drosophila melanogaster)
REACT:R-GGA-8853419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 promotes AURKA autophosphorylation (Gallus gallus)
REACT:R-HSA-1112510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6ST is tyrosine phosphorylated (Homo sapiens)
REACT:R-CFA-6786058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL4-bound IL4R1 (Canis familiaris)
REACT:R-HSA-1655848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
RHEA:62306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine
RHEA:37318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamine + H2O <=> glycine + L-glutamine
GO:0008440	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IP3 3-kinase activity
GO:0008440	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IP3K activity
GO:0008440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,4,5-trisphosphate 3-kinase activity
GO:0008440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol-trisphosphate 3-kinase activity
GO:0008440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity
GO:0008440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol trisphosphate 3-kinase activity
GO:0008440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ins(1,4,5)P(3) 3-kinase activity
GO:0008440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-trisphosphate 3-kinase activity
GO:0008440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ins(1,4,5)P3 3-kinase activity
GO:0003868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxyphenylpyruvic acid hydroxylase activity
GO:0003868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylpyruvate hydroxylase activity
GO:0003868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxyphenylpyruvate hydroxylase activity
GO:0003868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylpyruvic acid dioxygenase activity
GO:0003868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxyphenylpyruvic oxidase activity
GO:0003868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)
GO:0003868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxyphenylpyruvic hydroxylase activity
GO:0003868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxyphenylpyruvate oxidase activity
GO:0003868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylpyruvate dioxygenase activity
GO:0003868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxyphenylpyruvate dioxygenase activity
REACT:R-BTA-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Bos taurus)
REACT:R-RNO-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Rattus norvegicus)
RHEA:68024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + presqualene monophosphate = phosphate + presqualene alcohol
REACT:R-RNO-6799097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates ZNF420 (Rattus norvegicus)
REACT:R-BTA-213175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 oxidise AFB1 to AFXBO (Bos taurus)
REACT:R-HSA-1791158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CXXC1 (Homo sapiens)
REACT:R-PFA-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)
REACT:R-RNO-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Rattus norvegicus)
REACT:R-SCE-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Saccharomyces cerevisiae)
RHEA:20867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + phosphate <=> beta-D-glucose 1-phosphate + D-glucose 6-phosphate
RHEA:38153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + hydrogen sulfide => carbonyl sulfide + H2O
REACT:R-CFA-391937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP/CysLT receptor can bind cysteinyl leukotrienes (Canis familiaris)
REACT:R-SSC-879934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SHC1 is mediated by Y593 of the common beta chain (Sus scrofa)
REACT:R-RNO-211193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization  of DFF40 (Rattus norvegicus)
EC:2.4.1.365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protopanaxadiol-type ginsenoside-3-O-glucoside 2''-O-glucosyltransferase"
EC:2.4.1.365	skos:altLabel	"UGT94Q2"
EC:2.4.1.365	skos:prefLabel	"protopanaxadiol-type ginsenoside-3-O-glucoside 2''-O-glucosyltransferase"
REACT:R-DRE-8982640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Danio rerio)
REACT:R-MMU-417898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y4 receptor can bind to UTP (Mus musculus)
REACT:R-HSA-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
RHEA:26234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol
REACT:R-HSA-173680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C5 (Homo sapiens)
REACT:R-MMU-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Mus musculus)
REACT:R-GGA-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Gallus gallus)
RHEA:51793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + salicylate => 2,3-dihydroxybenzoate + H2O + NAD(+)
RHEA:14829	skos:altLabel	"O-acetylserine (thiol)-lyase"
RHEA:14829	skos:altLabel	"O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)"
RHEA:14829	skos:prefLabel	"cysteine synthase"
RHEA:14829	skos:altLabel	"O-acetyl-L-serine sulfohydrolase"
RHEA:14829	skos:altLabel	"O-acetylserine (thiol)-lyase A"
RHEA:14829	skos:altLabel	"O-acetylserine sulfhydrylase"
RHEA:14829	skos:altLabel	"cysteine synthetase"
RHEA:14829	skos:altLabel	"OAS sulfhydrylase"
RHEA:14829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine
RHEA:14829	skos:altLabel	"O-acetyl-L-serine sulfhydrylase"
RHEA:14829	skos:altLabel	"acetylserine sulfhydrylase"
RHEA:14829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine synthase"
RHEA:39466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O
REACT:R-MMU-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Mus musculus)
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acyl-activating enzyme activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA synthetase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lignoceroyl-CoA synthase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long chain fatty acyl-CoA synthetase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acid thiokinase (long-chain) activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LCFA synthetase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain acyl-coenzyme A synthetase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain acyl-CoA synthetase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acid-CoA ligase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain fatty acid activation
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pristanoyl-CoA synthetase
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-fatty-acid-CoA ligase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-fatty-acyl-CoA synthetase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain fatty acyl coenzyme A synthetase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA ligase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain acyl CoA synthetase activity
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiokinase
GO:0004467	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	stearoyl-CoA synthetase
REACT:R-SSC-2990880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6/NEK7 phosphorylates NUP98 (Sus scrofa)
RHEA:42724	skos:prefLabel	"27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase"
RHEA:42724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase"
RHEA:42724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:50962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine
REACT:R-HSA-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Homo sapiens)
REACT:R-SPO-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Schizosaccharomyces pombe)
REACT:R-SSC-372693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BCAR1 by SRC-PTK2 complex (Sus scrofa)
REACT:R-DME-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Drosophila melanogaster)
RHEA:66291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base
RHEA:34876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH
REACT:R-RNO-5683986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)
REACT:R-CFA-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Canis familiaris)
RHEA:69761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + nonanoate => H2O + NAD(+) + nonanal
RHEA:45640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-XTR-9013023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GEFs activate RHOB (Xenopus tropicalis)
REACT:R-CEL-3780997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG2:GYS2 (Caenorhabditis elegans)
REACT:R-RNO-8956676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TP73 (Rattus norvegicus)
RHEA:30656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dUMP => ADP + dUDP
REACT:R-SSC-373750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:ErbB2 (Sus scrofa)
RHEA:10397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + H2O + NAD(+) => a 2-oxocarboxylate + H(+) + NADH + NH4(+)
REACT:R-XTR-166387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The FA anion diffuses away laterally from UCP (Xenopus tropicalis)
RHEA:70228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA => (E)-2-benzylidenesuccinyl-CoA + H2O
REACT:R-CEL-2028598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS1 (Caenorhabditis elegans)
REACT:R-HSA-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
REACT:R-HSA-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Homo sapiens)
RHEA:64930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP + H(+) + phosphate => dADP + H2O
RHEA:49255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-fructose 1-phosphate(in) + L-histidyl-[protein]
RHEA:61649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[non-ribosomal peptide synthase] + salicylate => AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]
REACT:R-DDI-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Dictyostelium discoideum)
REACT:R-MMU-6783670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1 binds CLCF1 (Mus musculus)
REACT:R-CFA-8943987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCUBE1, SCUBE3 oligomerize (Canis familiaris)
RHEA:34861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocyclopentanecarboxylate + NH4(+) => 3-oxocyclopentanecarbonitrile + 2 H2O
REACT:R-GGA-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Gallus gallus)
RHEA:32704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O => 8-hydroxycopalyl diphosphate
RHEA:61415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(D-erythrulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine
REACT:R-SSC-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Sus scrofa)
RHEA:61035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine <=> 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-5213464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is phosphorylated (Danio rerio)
REACT:R-DRE-8853801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPN binds RET:GFRA4 (Danio rerio)
REACT:R-DME-214956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length EA is cleaved by SNK serine protease (Drosophila melanogaster)
REACT:R-MMU-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Mus musculus)
RHEA:68054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+) => a ribonucleotidyl-ribonucleotide-RNA + H2O
RHEA:27740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-alpha-D-ribose 1-phosphate + guanine => 2'-deoxyguanosine + phosphate
REACT:R-DME-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Drosophila melanogaster)
REACT:R-MMU-265424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Mus musculus)
REACT:R-HSA-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Homo sapiens)
REACT:R-HSA-2730860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
RHEA:70719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) = L-alanine(out)
REACT:R-GGA-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Gallus gallus)
RHEA:71861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate(in) => glycochenodeoxycholate(out)
RHEA:33690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-N-debenzoyltaxol + benzoyl-CoA <=> CoA + H(+) + taxol
REACT:R-HSA-5674019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds KSR1:MARK3 (Homo sapiens)
RHEA:56774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O => 2 AH2 + all-trans-adonixanthin + 2 O2
RHEA:70250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose <=> beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP
REACT:R-CEL-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Caenorhabditis elegans)
REACT:R-SSC-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Sus scrofa)
REACT:R-HSA-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Homo sapiens)
REACT:R-HSA-8948612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-19b microRNA binds CNOT6L mRNA (Homo sapiens)
RHEA:71117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhispidin + H2O + NAD(+) => H(+) + hispidin + NADH + O2
REACT:R-RNO-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Rattus norvegicus)
REACT:R-XTR-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)
REACT:R-HSA-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Homo sapiens)
RHEA:44855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(5Z)-tetradecenoyl-(R)-carnitine
RHEA:11825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate
RHEA:66052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + L-kynurenine = H2O + kynurenate + L-tryptophan
RHEA:63618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prunetin-C(8)-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate
RHEA:30313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + NAD(+) + xanthine => 7-methylxanthine + H(+) + NADH + O2
RHEA:39050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-77594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Canis familiaris)
RHEA:52833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxylimonen-2-one + H(+) + NADPH + O2 => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
REACT:R-PFA-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Plasmodium falciparum)
REACT:R-CFA-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Canis familiaris)
REACT:R-DME-879914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3 stimulation induces Vav binding to Tec kinase (Drosophila melanogaster)
REACT:R-DRE-8940561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP7 cleaves OPTC (Danio rerio)
REACT:R-GGA-9009308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 polyubiquitinates RUNX2 (Gallus gallus)
REACT:R-MMU-909722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-STAT2:p-STAT1 dimer (Mus musculus)
RHEA:65138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-CEL-5624951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNPO1 binds KIF17 dimer (Caenorhabditis elegans)
REACT:R-BTA-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Bos taurus)
REACT:R-DRE-1433395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of sSCF (Danio rerio)
REACT:R-BTA-373813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR2 binds ligands CXCL1 to 7 (Bos taurus)
RHEA:45121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-ipsdienol + NAD(+) => H(+) + ipsdienone + NADH
RHEA:23378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-D-erythronate + H(+) + NADH => L-threonate + NAD(+)
REACT:R-HSA-5683385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)
RHEA:62426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => (E)-caffeoyl-CoA + H2O
REACT:R-DME-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Drosophila melanogaster)
RHEA:49066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitetrol + H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol
REACT:R-DDI-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Dictyostelium discoideum)
RHEA:57586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:22864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine = D-lysine
RHEA:22864	skos:prefLabel	"lysine racemase"
RHEA:22864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine racemase"
REACT:R-GGA-193702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of the ICD migrates to the nucleus (Gallus gallus)
REACT:R-HSA-9697057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esxG binds esxH (Homo sapiens)
REACT:R-DRE-422048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acyl Ghrelin and C-Ghrelin are secreted (Danio rerio)
REACT:R-DDI-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Dictyostelium discoideum)
EC:3.1.1.4	skos:altLabel	"phosphatidolipase"
EC:3.1.1.4	skos:altLabel	"phosphatidase"
EC:3.1.1.4	skos:prefLabel	"phospholipase A2"
EC:3.1.1.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phospholipase A2"
EC:3.1.1.4	skos:altLabel	"phosphatidylcholine 2-acylhydrolase"
EC:3.1.1.4	skos:altLabel	"lecithinase A"
REACT:R-MMU-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Mus musculus)
RHEA:10220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine--tRNA ligase"
RHEA:10220	skos:altLabel	"tyrosyl-tRNA synthetase"
RHEA:10220	skos:altLabel	"tyrosyl-transfer ribonucleate synthetase"
RHEA:10220	skos:altLabel	"tyrosine-transfer ribonucleate synthetase"
RHEA:10220	skos:altLabel	"L-tyrosine-tRNA(Tyr) ligase (AMP-forming)"
RHEA:10220	skos:prefLabel	"tyrosine--tRNA ligase"
RHEA:10220	skos:altLabel	"tyrosyl-transfer ribonucleic acid synthetase"
RHEA:10220	skos:altLabel	"tyrosyl-tRNA ligase"
RHEA:10220	skos:altLabel	"tyrosine tRNA synthetase"
RHEA:10220	skos:altLabel	"tyrosine-transfer RNA ligase"
RHEA:10220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)
RHEA:10220	skos:altLabel	"tyrosyl-transfer RNA synthetase"
RHEA:10220	skos:altLabel	"tyrosine translase"
REACT:R-HSA-1295519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7R is phosphorylated on Y499 (Homo sapiens)
REACT:R-RNO-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)
RHEA:52874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate
RHEA:28706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(in) <=> Cu(2+)(out)
RHEA:47234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA
REACT:R-RNO-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Rattus norvegicus)
REACT:R-CFA-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Canis familiaris)
RHEA:57952	skos:prefLabel	"phenol 2-monooxygenase (NADH)"
RHEA:57952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + phenol = catechol + H2O + NAD(+)
RHEA:57952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenol 2-monooxygenase (NADH)"
REACT:R-SSC-173705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b binds C6 (Sus scrofa)
RHEA:12736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate
RHEA:34659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + S-adenosyl-L-methionine = 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
RHEA:67485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP
REACT:R-CFA-9014296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GEFs activate RAC2 (Canis familiaris)
REACT:R-BTA-3640844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 binds RibC-AXIN:TNKS complex (Bos taurus)
REACT:R-HSA-1236972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Escape of antigens from phagosome to cytosol (Homo sapiens)
REACT:R-RNO-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
REACT:R-DRE-2161907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Danio rerio)
REACT:R-CFA-9700149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds PLCG1 (Canis familiaris)
REACT:R-RNO-210283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and PLC gamma1 (Rattus norvegicus)
REACT:R-GGA-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)
REACT:R-HSA-9700171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates PLCG1 (Homo sapiens)
REACT:R-MMU-9707659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes:LY96 activates TLR4 (Mus musculus)
RHEA:42875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine
REACT:R-GGA-428007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled histidine and di-peptide cotransport (Gallus gallus)
REACT:R-CFA-2187332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic CMs translocate to extracellular region (Canis familiaris)
REACT:R-MMU-6784959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPHL hydrolyses VACV to ACV (Mus musculus)
REACT:R-DME-870479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) binds to ubiquitinated SMAD4 (Drosophila melanogaster)
RHEA:64889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[ACP] + tetradecanoate => AMP + diphosphate + tetradecanoyl-[ACP]
RHEA:46241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:20678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alizarin + UDP-alpha-D-glucose => 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP
REACT:R-SSC-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Sus scrofa)
REACT:R-CEL-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Caenorhabditis elegans)
RHEA:37570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
RHEA:53192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
GO:0050090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))
GO:0050090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannonate:NAD(P)+ 6-oxidoreductase activity
GO:0050090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannonate dehydrogenase activity
GO:0050090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannuronate reductase activity
GO:0050090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannonate dehydrogenase (NAD(P)+)
GO:0050090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity
REACT:R-DDI-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Dictyostelium discoideum)
GO:0008184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase activity
RHEA:34577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone => 2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CEL-198613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates p21Cip1 and p27Kip1 (Caenorhabditis elegans)
REACT:R-MMU-8852874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 binds C3d, C3dg, iC3b (Mus musculus)
RHEA:17631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose(out) => alpha,alpha-trehalose(in)
REACT:R-BTA-5661240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCXR tetramer reduces L-xylulose to xylitol (Bos taurus)
REACT:R-CEL-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Caenorhabditis elegans)
RHEA:36700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP => 8-desmethylnovobiocic acid + AMP + diphosphate
GO:0047218	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxycinnamoyl glucosyltransferase activity
GO:0047218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxycinnamate 4-beta-glucosyltransferase activity
GO:0047218	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity
GO:0047218	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity
GO:0047218	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-hydroxycinnamate glucosyltransferase activity
GO:0047218	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity
RHEA:35732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + tetradecanoyl-CoA => 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA
RHEA:31728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 + styrene => (2S)-2-phenyloxirane + FAD + H(+) + H2O
REACT:R-DRE-8874080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates PTK2 (Danio rerio)
REACT:R-DDI-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Dictyostelium discoideum)
REACT:R-CEL-201603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of PKC theta (Caenorhabditis elegans)
REACT:R-DRE-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Danio rerio)
RHEA:24526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:12171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allyl alcohol + NADP(+) <=> acrolein + H(+) + NADPH
REACT:R-CEL-8849350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Caenorhabditis elegans)
REACT:R-CFA-3640874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-RibC-AXIN is degraded by the proteasome (Canis familiaris)
REACT:R-SSC-450580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 (hnRNP D0) is ubiquitinylated (Sus scrofa)
REACT:R-DME-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Drosophila melanogaster)
RHEA:46644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + H(+) + NADPH = 5beta-dihydrocortisol + NADP(+)
RHEA:53953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate
RHEA:11847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + formate <=> CoA + pyruvate
REACT:R-GGA-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Gallus gallus)
REACT:R-HSA-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Homo sapiens)
GO:0102196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + H(+) + NADPH = cortisol + NADP(+)
GO:0102196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol dehydrogenase activity
REACT:R-GGA-427656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Gallus gallus)
REACT:R-MMU-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Mus musculus)
REACT:R-BTA-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Bos taurus)
REACT:R-RNO-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Rattus norvegicus)
GO:0016436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (uridine) methyltransferase activity
REACT:R-RNO-873927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of STAT1 dimer from active receptor unit (Rattus norvegicus)
RHEA:20927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [peptide]-C-terminal (2S)-2-hydroxyglycine <=> a [peptide]-C-terminal amide + glyoxylate
REACT:R-SSC-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Sus scrofa)
REACT:R-HSA-5610730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI2 (Homo sapiens)
REACT:R-CEL-73805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Caenorhabditis elegans)
REACT:R-XTR-444126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Xenopus tropicalis)
RHEA:48849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => 13-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-SSC-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
REACT:R-RNO-163010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Down Regulation of Emi1 through Phosphorylation of Emi1 (Rattus norvegicus)
RHEA:57745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + phylloquinol => [protein]-dithiol + phylloquinone
REACT:R-HSA-8854209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A binds JFC1 (Homo sapiens)
RHEA:18958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:58287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + NADP(+) <=> H(+) + NADPH + thymine
REACT:R-BTA-1980125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH binds DTX (Bos taurus)
REACT:R-BTA-8848993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated KHDRBS1 translocates to the cytosol (Bos taurus)
REACT:R-DRE-8870489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA4,(5,6) bind PI3P (Danio rerio)
RHEA:69774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty aldehyde + H2O + NAD(+) <=> a short-chain fatty acid + 2 H(+) + NADH
REACT:R-DRE-209536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkB is ubiquitinated and degraded (Danio rerio)
REACT:R-CEL-8964605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Caenorhabditis elegans)
REACT:R-DME-9605609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Drosophila melanogaster)
RHEA:53010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,poly-cis-polyprenyl diphosphate + n diphosphate => (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate
REACT:R-RNO-983194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-1 is a heterotetramer (Rattus norvegicus)
RHEA:11176	skos:prefLabel	"kojibiose phosphorylase"
RHEA:11176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kojibiose phosphorylase"
RHEA:11176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose
RHEA:31342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + holo-[ACP] <=> acetyl-[ACP] + AMP + diphosphate
GO:0050592	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CYP71E1 activity
GO:0050592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity
GO:0050592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetaldehyde oxime monooxygenase activity
GO:0050592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-cytochrome P450 reductase (CYP71E1)
GO:0050592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzeneacetaldehyde oxime monooxygenase activity
GO:0050592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P450II-dependent monooxygenase activity
GO:0050592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity
GO:0050592	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450-II-dependent monooxygenase activity
REACT:R-BTA-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Bos taurus)
RHEA:17294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + precorrin-3A => H2O + NAD(+) + precorrin-3B
REACT:R-CEL-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Caenorhabditis elegans)
REACT:R-MMU-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Mus musculus)
REACT:R-DDI-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)
RHEA:54039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) <=> [mycoredoxin]-S-mycothiol-L-cysteine + arsenite
REACT:R-HSA-443780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN (Homo sapiens)
GO:0018854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity
RHEA:61613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => 7-epi-cylindrospermopsin + CO2 + succinate
RHEA:12526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)
REACT:R-BTA-400677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rnd1 interacts with Plexin-B1:Sema4D (Bos taurus)
EC:3.4.23.48	skos:altLabel	"coagulase/fibrinolysin"
EC:3.4.23.48	skos:prefLabel	"plasminogen activator Pla"
EC:3.4.23.48	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plasminogen activator Pla"
RHEA:14101	skos:prefLabel	"deoxyhypusine monooxygenase"
RHEA:14101	skos:altLabel	"deoxyhypusine dioxygenase"
RHEA:14101	skos:altLabel	"DOHH"
RHEA:14101	skos:altLabel	"deoxyhypusine hydroxylase"
RHEA:14101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyhypusine monooxygenase"
RHEA:14101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O
RHEA:33412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O => (S)-malyl alpha-D-glucosaminide + acetate
RHEA:22804	skos:altLabel	"vomifoliol 4'-dehydrogenase"
RHEA:22804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S,9R)-vomifoliol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH
RHEA:22804	skos:prefLabel	"vomifoliol dehydrogenase"
RHEA:22804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vomifoliol dehydrogenase"
REACT:R-DME-390044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YKI is phosphorylated by and then dissociates from phosphorylated WTS (Drosophila melanogaster)
REACT:R-DDI-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Dictyostelium discoideum)
REACT:R-HSA-9710323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 or TP63 binds the GSDME gene (Homo sapiens)
REACT:R-XTR-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Xenopus tropicalis)
REACT:R-SSC-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Sus scrofa)
RHEA:38615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic ADP-beta-D-ribose + H2O = ADP-D-ribose
REACT:R-XTR-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Xenopus tropicalis)
RHEA:64678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyl 3-(methylsulfanyl)propanoate + CoA => 3-(methylsulfanyl)propanoyl-CoA + butan-1-ol
REACT:R-GGA-444208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLNR (GPR38) is a receptor for motilin (Gallus gallus)
REACT:R-SSC-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Sus scrofa)
REACT:R-SCE-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Saccharomyces cerevisiae)
RHEA:42727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Dictyostelium discoideum)
REACT:R-RNO-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Rattus norvegicus)
RHEA:31013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	camelliol C => (S)-2,3-epoxysqualene
RHEA:71715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-leucyl-L-leucine(out) = H(+)(in) + L-leucyl-L-leucine(in)
RHEA:60979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-en-1-ol + NAD(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADH
RHEA:25923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-7-ol <=> 7-hydroxyquinolin-2(1H)-one + AH2
REACT:R-XTR-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Xenopus tropicalis)
RHEA:14843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
RHEA:35867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:NMN adenylyltransferase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NMNAT activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine triphosphate-nicotinamide mononucleotide transadenylase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NMN adenylyltransferase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+ pyrophosphorylase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NAD(+) diphosphorylase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphopyridine nucleotide pyrophosphorylase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nicotinamide mononucleotide adenylyltransferase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NAD(+) pyrophosphorylase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nicotinamide adenine dinucleotide pyrophosphorylase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:nicotinamide-nucleotide adenylyltransferase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+ diphosphorylase activity
GO:0000309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide-nucleotide adenylyltransferase activity
REACT:R-HSA-9021948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPRIN1 gene expression is stimulated by MECP2 (Homo sapiens)
RHEA:24832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate
REACT:R-DME-3361751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin is replaced by repression complexes at the promoter (Drosophila melanogaster)
REACT:R-SCE-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)
REACT:R-HSA-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Homo sapiens)
RHEA:64168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethyl-L-serine = (2S)-2-aminobutanoate + formaldehyde
REACT:R-RNO-2213235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of nonameric complex in the endocytic pathway (Rattus norvegicus)
REACT:R-HSA-5607838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective UNC93B1 does not bind TLR3 (Homo sapiens)
REACT:R-RNO-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Rattus norvegicus)
RHEA:56415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol
RHEA:31162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH
RHEA:28531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XMP => phosphate + xanthosine
RHEA:30680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose + H2O => beta-D-glucose + D-glucose
RHEA:52179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-6804379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds TTC5 (Danio rerio)
REACT:R-MMU-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Mus musculus)
RHEA:22247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + UDP-alpha-D-xylose <=> H(+) + kaempferol 3-O-beta-D-xyloside + UDP
REACT:R-HSA-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Homo sapiens)
REACT:R-GGA-9679775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT binds COMT Inhibitors (Gallus gallus)
REACT:R-CFA-77327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Canis familiaris)
RHEA:28079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + NAD(+) => H(+) + NADH + phosphonoacetaldehyde
REACT:R-SPO-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Schizosaccharomyces pombe)
GO:0047897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate:dihydrofolate ligase (ADP-forming)
GO:0047897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate-dihydrofolate ligase activity
GO:0047897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrofolate formyltransferase activity
GO:0047897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyl dihydrofolate synthase activity
RHEA:50750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthalene-1,2,4,8-tetrol => H2O + juglone
RHEA:56901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine => globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP
GO:0016762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xyloglucan endotransglucosylase activity
GO:0016762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoxyloglucan transferase activity
GO:0016762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xyloglucan:xyloglucosyl transferase activity
GO:0016762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xyloglucan:xyloglucan xyloglucanotransferase activity
GO:0016762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-xyloglucan transferase activity
REACT:R-DRE-212432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DRIP coactivator complex (Danio rerio)
REACT:R-SSC-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Sus scrofa)
REACT:R-RNO-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)
REACT:R-HSA-480470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ZIC3 (Homo sapiens)
GO:0018521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity
GO:0018521	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)
RHEA:59938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O
REACT:R-PFA-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Plasmodium falciparum)
EC:2.7.99.1	skos:altLabel	"DiPPT"
EC:2.7.99.1	skos:altLabel	"pyrophosphate-protein phosphotransferase"
EC:2.7.99.1	skos:prefLabel	"triphosphate--protein phosphotransferase"
EC:2.7.99.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"triphosphate--protein phosphotransferase"
EC:2.7.99.1	skos:altLabel	"diphosphate--protein phosphotransferase"
REACT:R-RNO-5577213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-HSA-380234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)
REACT:R-CFA-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Canis familiaris)
REACT:R-DRE-6813740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDE1 hydrolyzes GroPIns (Danio rerio)
REACT:R-RNO-1433374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processing of SCF isoform 1 (Rattus norvegicus)
RHEA:60890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O
REACT:R-DRE-83790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Danio rerio)
RHEA:47440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) = 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH
RHEA:23461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl cetraxate + H2O => benzyl alcohol + cetraxate + H(+)
REACT:R-SPO-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Schizosaccharomyces pombe)
RHEA:40653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:20649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23,24-dihydrocucurbitacin B + NADP(+) = cucurbitacin B + H(+) + NADPH
RHEA:29111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + ubiquinone-8 = NADP(+) + ubiquinol-8
REACT:R-MMU-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Mus musculus)
RHEA:43216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine
GO:0008990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity
GO:0008990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (guanine-N2-)-methyltransferase activity
GO:0008990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity
GO:0008990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribosomal ribonucleate guanine-2-methyltransferase activity
REACT:R-RNO-508451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B is phosphorylated (Rattus norvegicus)
RHEA:69207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate
RHEA:69018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-pregnan-3,20-dione + H(+) + NADPH => 3alpha-hydroxy-5beta-pregnan-20-one + NADP(+)
REACT:R-CEL-8865182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7A hydrolyses K11diUb (Caenorhabditis elegans)
REACT:R-SSC-2179276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 monoubiquitinates SMAD3 (Sus scrofa)
REACT:R-HSA-8848150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds SOCS3 promoter (Homo sapiens)
REACT:R-DRE-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Danio rerio)
RHEA:31257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methyl-2-oxobutanoate => (2S)-2-acetolactate
REACT:R-MMU-9013004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the ER membrane (Mus musculus)
REACT:R-BTA-5610725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TULP3 is required for GPR161 localization in the cilium (Bos taurus)
REACT:R-HSA-9769235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGED1 binds NPAS4 (Homo sapiens)
RHEA:18152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-galactosamine 6-phosphate <=> acetate + D-galactosamine 6-phosphate
REACT:R-SPO-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Schizosaccharomyces pombe)
REACT:R-MMU-451757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of nephrin and KIRREL2, KIRREL3 (Mus musculus)
REACT:R-SSC-5218838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXN binds p-6Y,S732-PTK2 (Sus scrofa)
REACT:R-SSC-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Sus scrofa)
RHEA:58831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10R)-epoxy-octadecanoate + H2O <=> 9R,10R-dihydroxyoctadecanoate
REACT:R-DME-112435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin BC complex (Drosophila melanogaster)
REACT:R-DRE-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Danio rerio)
REACT:R-GGA-4420206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SRC-1 (Gallus gallus)
EC:1.3.99.4	skos:prefLabel	"3-oxosteroid 1-dehydrogenase"
EC:1.3.99.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxosteroid 1-dehydrogenase"
REACT:R-HSA-2028555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Homo sapiens)
REACT:R-CFA-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Canis familiaris)
REACT:R-HSA-9710354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds cardiolipin (Homo sapiens)
GO:0070405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonium binding
GO:0070405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammonium ion binding
REACT:R-HSA-8987063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Homo sapiens)
REACT:R-DME-193743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
RHEA:25365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + momilactone A + NADH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+)
RHEA:53014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + chlorohydroquinone + glutathione disulfide + H(+) => 2,5-dichlorohydroquinone + 2 glutathione
RHEA:38502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O <=> a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)
REACT:R-DME-114254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS binds to APAF1 (Drosophila melanogaster)
RHEA:64957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP + 2 H2O => dTMP + 2 H(+) + 2 phosphate
RHEA:31613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + rhodopin => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene
GO:0070027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon monoxide sensor activity
GO:0070027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon monoxide sensing activity
REACT:R-BTA-5250210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Bos taurus)
REACT:R-CFA-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Canis familiaris)
RHEA:11634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H(+) + hydrogenselenide + L-alanine => AH2 + L-selenocysteine
RHEA:24132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-galactopyranose mutase"
RHEA:24132	skos:prefLabel	"UDP-galactopyranose mutase"
RHEA:24132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose = UDP-alpha-D-galactofuranose
REACT:R-DME-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)
RHEA:45654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)
GO:0047221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity
GO:0047221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	floridoside phosphate synthase activity
GO:0047221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity
GO:0047221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity
GO:0047221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	floridoside-phosphate synthase activity
GO:0047221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	floridoside phosphate synthetase activity
GO:0047221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity
GO:0047221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FPS
GO:0047221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity
RHEA:50087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurolithocholate 3-sulfate(in) <=> ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)
GO:0018833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]
GO:0018833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DDT-as
GO:0018833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DDTase activity
GO:0018833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DDT-ase activity
GO:0018833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity
GO:0018833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDT-dehydrochlorinase activity
GO:0018833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDT dehydrochlorinase activity
REACT:R-RNO-5623643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH13 reduces atRAL to atROL (Rattus norvegicus)
REACT:R-MMU-5665999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 translocates from cytosol to the nucleus (Mus musculus)
REACT:R-SSC-5693153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1K dephosphorylates p-BCKDH (Sus scrofa)
REACT:R-CFA-6805740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 methylates TP53 (Canis familiaris)
REACT:R-DDI-2993763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Dictyostelium discoideum)
REACT:R-HSA-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Homo sapiens)
RHEA:15874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)
REACT:R-RNO-163214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from reduced cytochrome c to molecular oxygen (Rattus norvegicus)
REACT:R-SSC-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Sus scrofa)
RHEA:65339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin T + H(+) + NADPH + O2 <=> chrodrimanin A + H2O + NADP(+)
REACT:R-CFA-6793685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated TP53 translocates to the cytosol (Canis familiaris)
REACT:R-HSA-5696482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTF1 binds LIFR:JAKs (Homo sapiens)
RHEA:67943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctanoate + O2 <=> 2-oxooctanoate + H2O2
RHEA:33777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine
RHEA:68651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-cysteine <=> H(+) + hydrogen sulfide + L-lanthionine
REACT:R-MMU-202510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1-TAB2 complex (Mus musculus)
REACT:R-HSA-3322009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Homo sapiens)
REACT:R-DRE-193713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Danio rerio)
REACT:R-DRE-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Danio rerio)
GO:0004135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextrin 6-alpha-D-glucosidase activity
GO:0004135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextrin-1,6-glucosidase activity
GO:0004135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amylo-alpha-1,6-glucosidase activity
GO:0004135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity
GO:0004135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amylo-1,6-glucosidase activity
GO:0004135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amylopectin 1,6-glucosidase activity
REACT:R-DRE-1296127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of voltage gated Potassium channels (Danio rerio)
REACT:R-DME-77590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CstF to the CPSF Bound Pre-mRNA (Drosophila melanogaster)
RHEA:31701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin]
REACT:R-SSC-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Sus scrofa)
REACT:R-DME-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Drosophila melanogaster)
REACT:R-MMU-1483089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is converted to PS by PTDSS2 (Mus musculus)
REACT:R-SPO-5686430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81 binds EME1, EME2 (Schizosaccharomyces pombe)
REACT:R-BTA-417927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y2 receptor binds ATP and UTP (Bos taurus)
REACT:R-XTR-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Xenopus tropicalis)
RHEA:36719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-hexacosenoylsphinganine
RHEA:52980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]
RHEA:28769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + chemical entity + H(+) + nitrite => ethylnitronate + O2
GO:0103106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brassinolide 23-O-glucosyltransferase activity
RHEA:48122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + N-acetylneuraminate => ganglioside GD3 + H2O
RHEA:39052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholesterol(in) + H2O => ADP + cholesterol(out) + H(+) + phosphate
REACT:R-CFA-6799191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Canis familiaris)
REACT:R-XTR-917693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESCRT Disassembly (Xenopus tropicalis)
REACT:R-DRE-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Danio rerio)
REACT:R-DDI-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Dictyostelium discoideum)
RHEA:31849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	shionone => (S)-2,3-epoxysqualene
REACT:R-GGA-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Gallus gallus)
REACT:R-MMU-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Mus musculus)
RHEA:51997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0030572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidyltransferase activity
RHEA:44612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
RHEA:27966	skos:prefLabel	"6-carboxytetrahydropterin synthase"
RHEA:27966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate
RHEA:27966	skos:altLabel	"CPH4 synthase"
RHEA:27966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-carboxytetrahydropterin synthase"
RHEA:57726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 Na(+)(out) + pyruvate => H(+) + 2 Na(+)(in) + oxaloacetate
RHEA:68645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => alpha-thujene + diphosphate
GO:0033164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolipid 6-alpha-mannosyltransferase activity
GO:0033164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	initiation-specific alpha-1,6-mannosyltransferase activity
GO:0033164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity
GO:0033164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity
GO:0033164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolipid 1,6-alpha-mannosyltransferase activity
GO:0033164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase activity
RHEA:21164	skos:prefLabel	"carboxylesterase"
RHEA:21164	skos:altLabel	"procaine esterase"
RHEA:21164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)
RHEA:21164	skos:altLabel	"ali-esterase"
RHEA:21164	skos:altLabel	"monobutyrase"
RHEA:21164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxylesterase"
RHEA:21164	skos:altLabel	"cocaine esterase"
RHEA:21164	skos:altLabel	"B-esterase"
RHEA:21164	skos:altLabel	"methylbutyrase"
RHEA:54167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Sus scrofa)
RHEA:37821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA
REACT:R-CEL-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Caenorhabditis elegans)
REACT:R-HSA-448603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33:IL1RL1 binds IL1RAP-1 (Homo sapiens)
REACT:R-DME-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-DRE-9697747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at TNFR signaling complex (Danio rerio)
REACT:R-DRE-8854908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates RET:GDNF:GFRA dimer (Danio rerio)
RHEA:72836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cUAMP + H2O => H(+) + U[3'-5']pAp[3']
REACT:R-RNO-981832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMUR2 binds neuromedin-S (Rattus norvegicus)
REACT:R-SCE-3322019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-b (Saccharomyces cerevisiae)
RHEA:54453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in tRNA + NAD(+) => a uridine in tRNA + H(+) + NADH
REACT:R-BTA-9014812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBOs bind keratan sulfate (Bos taurus)
RHEA:31151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-selenocystathionine = 2-oxobutanoate + L-selenocysteine + NH4(+)
REACT:R-DDI-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Dictyostelium discoideum)
RHEA:67400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = allo-aromadendrene + diphosphate
RHEA:57045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apionate + NAD(+) => 3-oxoisoapionate + H(+) + NADH
REACT:R-GGA-2002401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Gallus gallus)
GO:0103015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxy-L-arabinose transferase activity
REACT:R-HSA-9749647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES2 hydrolyzes ASA- (Homo sapiens)
REACT:R-MMU-216050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Mus musculus)
REACT:R-CEL-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Caenorhabditis elegans)
RHEA:51412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate
REACT:R-CFA-168849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAX protein (Canis familiaris)
RHEA:54265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate
REACT:R-DDI-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Dictyostelium discoideum)
EC:3.4.24.76	skos:prefLabel	"flavastacin"
EC:3.4.24.76	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavastacin"
REACT:R-GGA-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Gallus gallus)
RHEA:68638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sabinene => (2E)-geranyl diphosphate
REACT:R-SSC-5685902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Sus scrofa)
REACT:R-BTA-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Bos taurus)
RHEA:61738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rubusoside + UDP => steviolmonoside + UDP-alpha-D-glucose
RHEA:65180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + protoaustinoid B = A + H2O + preaustinoid A
REACT:R-RNO-9014294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the plasma membrane (Rattus norvegicus)
REACT:R-BTA-5621355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Bos taurus)
RHEA:35290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + chloramphenicol(in) + H2O <=> ADP + chloramphenicol(out) + H(+) + phosphate
REACT:R-DRE-381412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP2 binds IGF forming IGF:IGFBP2 (Danio rerio)
RHEA:21238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + NADP(+) + NH4(+) => anthranilate + 2 H(+) + NADPH + O2
RHEA:36476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA
RHEA:60078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+) => 4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2
GO:0000513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin severing activator activity
RHEA:72712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cathenamine + H(+) => 4,21-dehydrogeissoschizine
REACT:R-SSC-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Sus scrofa)
REACT:R-BTA-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Bos taurus)
REACT:R-CEL-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Caenorhabditis elegans)
REACT:R-MMU-183067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Localization of CBL:GRB2 to the membrane (Mus musculus)
RHEA:55222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2
GO:0106242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kolavenyl diphosphate synthase activity
REACT:R-HSA-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Homo sapiens)
RHEA:54607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + decanoyl-CoA + O2 <=> 2-hydroxydecanoyl-CoA + CO2 + succinate
REACT:R-MMU-198621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates caspase-9 (Mus musculus)
RHEA:62595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH
REACT:R-CFA-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Canis familiaris)
REACT:R-RNO-9749971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Rattus norvegicus)
RHEA:37682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-DME-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Drosophila melanogaster)
REACT:R-XTR-419334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melatonin receptors can bind melatonin (Xenopus tropicalis)
RHEA:63375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + L-cysteinyl-[protein] <=> an S-acyl-L-cysteinyl-[protein] + CoA
RHEA:45014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + octadecanoate => H2O + N-octadecanoyl-(4R)-hydroxysphinganine
REACT:R-CEL-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Caenorhabditis elegans)
RHEA:34489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+) => dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol
RHEA:25622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate => tuberculosinyl diphosphate
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobutyrate-2-ketoglutarate aminotransferase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-aminobutyrate-alpha-ketoglutarate transaminase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-aminobutyric acid-2-oxoglutarate transaminase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GABA-2-oxoglutarate aminotransferase activity
GO:0034386	skos:altLabel	"gamma-amino-N-butyrate transaminase"
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GABA-2-oxoglutarate transaminase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-aminobutyrate--2-oxoglutarate transaminase"
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GABA-alpha-ketoglutarate transaminase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GABA-alpha-ketoglutaric acid transaminase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GABA-alpha-oxoglutarate aminotransferase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobutyrate-2-oxoglutarate transaminase activity
GO:0034386	skos:altLabel	"beta-alanine--oxoglutarate aminotransferase"
GO:0034386	skos:altLabel	"GABA transaminase"
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde
GO:0034386	skos:prefLabel	"4-aminobutyrate--2-oxoglutarate transaminase"
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobutanoate:2-oxoglutarate aminotransferase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyrate:2-oxoglutarate transaminase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GABA-oxoglutarate aminotransferase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobutyrate-2-oxoglutarate aminotransferase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GABA-alpha-ketoglutarate aminotransferase activity
GO:0034386	skos:altLabel	"4-aminobutyrate aminotransferase"
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity
GO:0034386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GABA-oxoglutarate transaminase activity
REACT:R-GGA-212263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 trimethylates histone H3 at lysine-27 (Gallus gallus)
RHEA:66066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine
REACT:R-HSA-8944684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-205 microRNA binds PTEN mRNA (Homo sapiens)
REACT:R-HSA-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Homo sapiens)
RHEA:14536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine + H2O <=> creatine
REACT:R-CFA-3209159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERF translocates to the cytosol (Canis familiaris)
REACT:R-SSC-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
RHEA:70209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-4E,14Z-dienine-1-phosphate(out) => sphinga-4E,14Z-dienine-1-phosphate(in)
REACT:R-GGA-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Gallus gallus)
RHEA:55041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-DME-5671993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT-3 binds DLG4 (Drosophila melanogaster)
REACT:R-DRE-8937613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHBP binds CRH (Danio rerio)
REACT:R-GGA-1454822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP1,2,8,13, PRSS2 (Gallus gallus)
RHEA:32108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine => H(+) + pterostilbene + S-adenosyl-L-homocysteine
RHEA:44211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyltridecanoate + ATP + CoA <=> 12-methyltridecanoyl-CoA + AMP + diphosphate
REACT:R-HSA-191786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP complex assembly (Homo sapiens)
RHEA:17660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + dihydroxyacetone phosphate <=> a 1-acylglycerone 3-phosphate + CoA
REACT:R-MMU-3239014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates TP53 (Mus musculus)
REACT:R-RNO-112437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NELF complex  (Rattus norvegicus)
REACT:R-DRE-5656064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FLRT1,2,3 (Danio rerio)
RHEA:59603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methoxytryptamine + H2O + O2 <=> 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)
RHEA:18747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) => 2 juglone + O2
REACT:R-HSA-5624956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds INPP5E (Homo sapiens)
RHEA:54228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine = 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine
REACT:R-DDI-192331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)
RHEA:68789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate
REACT:R-DME-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Drosophila melanogaster)
RHEA:45463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine
GO:0004157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydropyrimidine hydrase activity
GO:0004157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydantoin peptidase activity
GO:0004157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydropyrimidinase activity
GO:0004157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydantoinase activity
GO:0004157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6-dihydropyrimidine amidohydrolase activity
GO:0004157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydropyrimidinase"
GO:0004157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine hydrase activity
GO:0004157	skos:prefLabel	"dihydropyrimidinase"
GO:0004157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-hydantoinase activity
GO:0004157	skos:altLabel	"hydantoinase"
REACT:R-MMU-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Mus musculus)
REACT:R-HSA-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
REACT:R-SPO-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Schizosaccharomyces pombe)
RHEA:70175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->4)-D-galactose + phosphate = alpha-D-glucose 1-phosphate + D-galactose
REACT:R-DME-8959462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Drosophila melanogaster)
REACT:R-BTA-937075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated TAK1 leaves activated TLR receptor complex (Bos taurus)
REACT:R-DRE-5218916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPK2/3 phosphorylates HSP27 (Danio rerio)
RHEA:45720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)
REACT:R-XTR-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Xenopus tropicalis)
REACT:R-SSC-4754176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR3-histone H3 (Sus scrofa)
RHEA:45630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein] => holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein]
REACT:R-DME-2179276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 monoubiquitinates SMAD3 (Drosophila melanogaster)
REACT:R-CFA-9674816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Canis familiaris)
REACT:R-CFA-6787757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates acidic AAs (Canis familiaris)
REACT:R-HSA-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Homo sapiens)
REACT:R-SPO-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Schizosaccharomyces pombe)
REACT:R-BTA-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Bos taurus)
RHEA:33488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA => CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine
REACT:R-CEL-3322014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-a (Caenorhabditis elegans)
REACT:R-BTA-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Bos taurus)
RHEA:10423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + taurine <=> L-alanine + sulfoacetaldehyde
RHEA:15872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-alanine <=> D-glutamate + pyruvate
GO:0043815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GAR transformylase 2
GO:0043815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-phosphoribosylglycinamide transformylase 2
GO:0043815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GART 2
GO:0043815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosylglycinamide formyltransferase 2 activity
GO:0043815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate-dependent GAR transformylase activity
REACT:R-SSC-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Sus scrofa)
REACT:R-DME-4332235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds TGFBR2 (Drosophila melanogaster)
REACT:R-MMU-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Mus musculus)
RHEA:72206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(out) + hydrogencarbonate(in) <=> 2 chloride(in) + hydrogencarbonate(out)
REACT:R-HSA-8987129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Homo sapiens)
REACT:R-CFA-202459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Bcl10 (Canis familiaris)
REACT:R-CFA-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Canis familiaris)
REACT:R-XTR-5684008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBN binds KPNA2 (Xenopus tropicalis)
RHEA:10075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylglycine + S-adenosyl-L-methionine <=> glycine betaine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Danio rerio)
RHEA:38664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)
REACT:R-RNO-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Rattus norvegicus)
RHEA:21971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate <=> 3-dehydroquinate + phosphate
REACT:R-BTA-2990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO1 to UBA2:SAE1 (Bos taurus)
REACT:R-XTR-5654664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)
RHEA:58131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:12454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP
REACT:R-MMU-9755304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUL1 ubiquitinates UBXN7 (Mus musculus)
GO:0008946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligonucleotidase activity
GO:0008946	skos:prefLabel	"oligonucleotidase"
GO:0008946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligonucleotidase"
REACT:R-RNO-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Rattus norvegicus)
RHEA:49131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine
GO:0047701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vicianosidase activity
GO:0047701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	b-L-arabinosidase activity
GO:0047701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-arabinosidase activity
GO:0047701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-L-arabinoside arabinohydrolase activity
REACT:R-HSA-1222644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TrxA/B1 reactivates Tpx (Homo sapiens)
RHEA:19208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + 2 H2O <=> diphosphate + dUMP + NH4(+)
RHEA:38599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase"
RHEA:38599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + nicotinate = nicotinamide + nicotinate-adenine dinucleotide phosphate
RHEA:38599	skos:altLabel	"diphosphopyridine nucleosidase"
RHEA:38599	skos:prefLabel	"2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase"
REACT:R-CEL-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)
GO:0140070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen peroxide transmembrane transporter activity
GO:0140070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen peroxide channel activity
RHEA:29204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + menaquinol-8 => dimethyl sulfide + H2O + menaquinone-8
REACT:R-CFA-2294590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds phosphorylated condensin II complex (Canis familiaris)
REACT:R-HSA-2471621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin degradation by cathepsins (Homo sapiens)
REACT:R-GGA-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Gallus gallus)
RHEA:55998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
REACT:R-CFA-400071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Canis familiaris)
REACT:R-RNO-9749609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCHE hydrolyzes ASA- (Rattus norvegicus)
REACT:R-CFA-879674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD97 binds CD55 (Canis familiaris)
RHEA:66803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Danio rerio)
REACT:R-RNO-205118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 polyubiquitinates NRIF (Rattus norvegicus)
REACT:R-MMU-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)
REACT:R-GGA-391933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP3 receptor can bind PGE2 (Gallus gallus)
RHEA:53458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol
RHEA:11465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + L,L-homocystine => glutathione disulfide + 2 L-homocysteine
RHEA:45209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] => Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M
RHEA:71287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-arginine(out) + 2 Na(+)(out) = chloride(in) + L-arginine(in) + 2 Na(+)(in)
REACT:R-BTA-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Bos taurus)
REACT:R-HSA-211482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF1A-dependent synthesis of FOXA3 (Homo sapiens)
REACT:R-CEL-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
RHEA:57568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5618098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Sus scrofa)
REACT:R-CEL-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Caenorhabditis elegans)
REACT:R-CFA-9654525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Canis familiaris)
REACT:R-DRE-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Danio rerio)
REACT:R-SSC-9626832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Sus scrofa)
REACT:R-PFA-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Plasmodium falciparum)
RHEA:42098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + nebramycin 5' + phosphate => ATP + carbamoyl phosphate + H2O + tobramycin
REACT:R-HSA-4568846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 (Homo sapiens)
RHEA:20896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"urea carboxylase"
RHEA:20896	skos:altLabel	"urease (ATP-hydrolyzing)"
RHEA:20896	skos:prefLabel	"urea carboxylase"
RHEA:20896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + urea = ADP + H(+) + phosphate + urea-1-carboxylate
RHEA:20896	skos:altLabel	"ATP--urea amidolyase"
RHEA:20896	skos:altLabel	"urea amidolyase"
RHEA:20896	skos:altLabel	"urea carboxylase (hydrolyzing)"
RHEA:20896	skos:altLabel	"UALase"
RHEA:20896	skos:altLabel	"UCA"
RHEA:17290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate
RHEA:21116	skos:prefLabel	"maltose phosphorylase"
RHEA:21116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maltose phosphorylase"
RHEA:21116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + phosphate = beta-D-glucose 1-phosphate + D-glucose
REACT:R-SSC-8848077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAP2 (Sus scrofa)
REACT:R-DRE-8983371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Danio rerio)
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain keto acid dehydrogenase kinase activity
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BCODH kinase activity
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BCK
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK2
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain alpha-ketoacid dehydrogenase kinase activity
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain 2-oxo acid dehydrogenase kinase activity
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity
GO:0047323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BCKD kinase activity
REACT:R-MMU-448632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimerizes (Mus musculus)
RHEA:39332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)
GO:0008908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3 dihydro-2,3 dihydroxybenzoate synthase activity
GO:0008908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxy-2,3-dihydrobenzoate synthase activity
GO:0008908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isochorismate pyruvate-hydrolase activity
GO:0008908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydro-2,3-dihydroxybenzoate synthase activity
GO:0008908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxy-2,3-dihydrobenzoic synthase activity
GO:0008908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochorismatase activity
REACT:R-DRE-5668481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protesomal degradation of K48polyUb-TRAF3 (Danio rerio)
RHEA:25397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (9Z,12Z)-octadecadienoate + O2
RHEA:24953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O => ADP + H(+) + N-acetyl-D-muramate 6-phosphate
REACT:R-DRE-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Danio rerio)
GO:0047150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	betaine-homocysteine methyltransferase activity
GO:0047150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine-homocysteine S-methyltransferase activity
GO:0047150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	betaine-homocysteine transmethylase activity
GO:0047150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethylammonioacetate:L-homocysteine S-methyltransferase activity
REACT:R-PFA-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)
REACT:R-DRE-5683930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WICH phosphorylates H2AFX on Y142 (Danio rerio)
RHEA:23032	skos:altLabel	"AIR synthase"
RHEA:23032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosylformylglycinamidine cyclo-ligase"
RHEA:23032	skos:altLabel	"AIR synthetase"
RHEA:23032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate
RHEA:23032	skos:altLabel	"AIRS"
RHEA:23032	skos:prefLabel	"phosphoribosylformylglycinamidine cyclo-ligase"
RHEA:23032	skos:altLabel	"phosphoribosyl-aminoimidazole synthetase"
RHEA:23032	skos:altLabel	"phosphoribosylaminoimidazole synthetase"
REACT:R-HSA-446391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the PINCH-ILK-parvin complex (Homo sapiens)
RHEA:25339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + urea => isocyanate + NH4(+)
REACT:R-SCE-6791219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Saccharomyces cerevisiae)
RHEA:17275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + 2 H(+) + NADH => (4-hydroxyphenyl)acetaldehyde + H2O + NAD(+)
REACT:R-DDI-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Dictyostelium discoideum)
REACT:R-XTR-9634834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACHEIs bind ACHE (Xenopus tropicalis)
REACT:R-MMU-4647594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAHF formation (Mus musculus)
REACT:R-XTR-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Xenopus tropicalis)
RHEA:59367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)
REACT:R-GGA-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Gallus gallus)
REACT:R-HSA-400282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRY proteins are ubiquitinylated (Homo sapiens)
REACT:R-CFA-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Canis familiaris)
REACT:R-GGA-1474213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP1,8,9,13 (Gallus gallus)
REACT:R-CFA-1236943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigen peptide onto MHC class I molecule (Canis familiaris)
RHEA:62427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + H2O <=> 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA
RHEA:27935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-D-aspartate => glycine + glyoxylate
REACT:R-GGA-909724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IFNAR1 (Gallus gallus)
REACT:R-XTR-2682349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Xenopus tropicalis)
RHEA:51313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine
REACT:R-BTA-9664881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Bos taurus)
RHEA:30707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + pyruvate = 4-aminobutanal + L-alanine
RHEA:30707	skos:prefLabel	"putrescine--pyruvate transaminase"
RHEA:30707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"putrescine--pyruvate transaminase"
RHEA:57013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H2O + sulfite => a menaquinol + sulfate
RHEA:63443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GTP + H(+) <=> 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate
REACT:R-SSC-8852331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 translocates to the nucleus (Sus scrofa)
RHEA:60005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate
REACT:R-MMU-378513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Mus musculus)
REACT:R-XTR-209973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is diiodinated (Xenopus tropicalis)
RHEA:18157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate
RHEA:30231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine = (2E,6E)-farnesal + H2O2 + L-cysteine
REACT:R-CFA-5205652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 recruits Parkin to the outer mitochondrial membrane. (Canis familiaris)
REACT:R-RNO-169719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted CD14 binds LPS (Rattus norvegicus)
REACT:R-HSA-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Homo sapiens)
REACT:R-DRE-1236967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alkalization of the phagosomal lumen by NOX2 (Danio rerio)
RHEA:57460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP
RHEA:40241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + dodecanedioyl-CoA => ATP + CoA + dodecanedioate
RHEA:56813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 => 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate
RHEA:48001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)
REACT:R-RNO-8959462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Rattus norvegicus)
RHEA:14195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + A + H2O => 3-hydroxybenzoate + AH2 + O2
REACT:R-DRE-9714480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the mitochondrial membrane (Danio rerio)
REACT:R-MMU-1168638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated IKK phosphorylates I-kappaB (Mus musculus)
REACT:R-MMU-174238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)
REACT:R-CFA-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Canis familiaris)
REACT:R-RNO-68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated geminin is degraded by the proteasome (Rattus norvegicus)
EC:2.1.1.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylethanolamine N-methyltransferase"
EC:2.1.1.28	skos:altLabel	"noradrenaline N-methyltransferase"
EC:2.1.1.28	skos:prefLabel	"phenylethanolamine N-methyltransferase"
REACT:R-GGA-9008692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds SMAD3 (Gallus gallus)
REACT:R-SSC-3341343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Sus scrofa)
RHEA:40127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-bisabolene => (S)-beta-macrocarpene
RHEA:46036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + UTP = dCMP + H(+) + UDP
RHEA:52177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5244503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botE HC:LC binds SV2A or B and GT1b on the target cell surface (Homo sapiens)
REACT:R-SCE-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Saccharomyces cerevisiae)
REACT:R-BTA-5216234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)
RHEA:61545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Danio rerio)
REACT:R-SSC-1250189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Sus scrofa)
REACT:R-BTA-8987223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10RB binds TYK2 (Bos taurus)
REACT:R-BTA-5654565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Bos taurus)
REACT:R-HSA-1791084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SYVN1 (HRD1) (Homo sapiens)
REACT:R-CFA-5624133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3:GTP binds the UNC119B complex (Canis familiaris)
REACT:R-MMU-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Mus musculus)
REACT:R-DME-5654600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
RHEA:66060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxohexanoate + L-kynurenine = H2O + kynurenate + L-2-aminohexanoate
RHEA:50378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ceramide(out) + ADP + H(+) + phosphate => a ceramide(in) + ATP + H2O
REACT:R-DME-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Drosophila melanogaster)
RHEA:68395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + peracetic acid <=> acetate + H(+) + H2O2
RHEA:38769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
REACT:R-CFA-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Canis familiaris)
RHEA:19412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NAD(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH
RHEA:10150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deaminohydroxyblasticidin S + NH4(+) => blasticidin S + H(+) + H2O
REACT:R-HSA-6784861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG binds LPL dimer (Homo sapiens)
RHEA:21560	skos:altLabel	"vitamin K 2,3-epoxide reductase"
RHEA:21560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 1,4-dithiothreitol + 2,3-epoxyphylloquinone
RHEA:21560	skos:prefLabel	"vitamin-K-epoxide reductase (warfarin-insensitive)"
RHEA:21560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vitamin-K-epoxide reductase (warfarin-insensitive)"
RHEA:64687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-alpha-D-glucose <=> 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP
RHEA:20258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyloxindole + NADP(+) => 3-methyleneoxindole + H(+) + NADPH
RHEA:53347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20a) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20a) in tRNA
REACT:R-DDI-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Dictyostelium discoideum)
REACT:R-MMU-216082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaXbeta2 with fibrin (Mus musculus)
REACT:R-CEL-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Caenorhabditis elegans)
REACT:R-HSA-180622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vpr binds nucleoporins (Homo sapiens)
REACT:R-DME-1964496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds TRIM32 or TRIM56  (Drosophila melanogaster)
REACT:R-XTR-381262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPARG:RXRA heterodimer (ARF6 complex) (Xenopus tropicalis)
REACT:R-BTA-5696365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)
RHEA:48817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
REACT:R-PFA-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Plasmodium falciparum)
REACT:R-BTA-9026003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Bos taurus)
REACT:R-DME-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Drosophila melanogaster)
RHEA:72181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + tauro-beta-muricholate(in) => 2 Na(+)(out) + tauro-beta-muricholate(out)
REACT:R-SCE-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Saccharomyces cerevisiae)
REACT:R-DRE-5362551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Danio rerio)
RHEA:11496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uracilylalanine synthase"
RHEA:11496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate + H(+)
RHEA:11496	skos:altLabel	"O(3)-acetyl-L-serine acetate-lyase (adding uracil)"
RHEA:11496	skos:prefLabel	"uracilylalanine synthase"
RHEA:11496	skos:altLabel	"isowillardiine synthase"
RHEA:11496	skos:altLabel	"willardiine synthase"
REACT:R-CEL-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Caenorhabditis elegans)
RHEA:65557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside GalGb4Cer + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc
REACT:R-MMU-112381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Mus musculus)
REACT:R-GGA-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Gallus gallus)
RHEA:43684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate = AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]
REACT:R-DDI-2161964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Dictyostelium discoideum)
REACT:R-RNO-5668714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX1 complex (Rattus norvegicus)
RHEA:61449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tigecycline => 11a-hydroxytigecycline + H2O + NADP(+)
REACT:R-SSC-9009817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acitretin binds to RAR:RXR (Sus scrofa)
RHEA:25526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-GGA-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Gallus gallus)
REACT:R-RNO-947673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanin-concentrating hormone receptors bind MCH (Rattus norvegicus)
REACT:R-CFA-2730856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Canis familiaris)
REACT:R-RNO-2731122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2 & 4 bind VTN (Rattus norvegicus)
REACT:R-DRE-8949668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YME1L1 proteolyzes unassembled proSMDT1 (Danio rerio)
REACT:R-XTR-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Xenopus tropicalis)
REACT:R-RNO-937034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino (Rattus norvegicus)
REACT:R-MMU-8987120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IFNLR1 (Mus musculus)
GO:0102295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity
RHEA:10161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-iditol + NAD(+) => H(+) + keto-L-sorbose + NADH
REACT:R-RNO-9696268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds effectors (Rattus norvegicus)
RHEA:31758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxepin-2(3H)-ylideneacetyl-CoA + H2O <=> 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde
RHEA:38906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin(in) + ATP + H2O <=> a sphingomyelin(out) + ADP + H(+) + phosphate
REACT:R-HSA-74101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerization of 11c-retinyl to at-retinyl (Homo sapiens)
RHEA:69262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate
RHEA:51490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaetidylethanolamine + CO2 => archaetidylserine + H(+)
REACT:R-DME-5690080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP3,SAGA deubiquitinate Histone H2A,H2B (Drosophila melanogaster)
REACT:R-XTR-2465934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL translocates from Muller cells to cone photoreceptor cells (Xenopus tropicalis)
REACT:R-SSC-397835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:Gq (active) dissociate (Sus scrofa)
REACT:R-CEL-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Caenorhabditis elegans)
REACT:R-CFA-6807106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN undergoes monoubiquitination (Canis familiaris)
REACT:R-DRE-165692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of 4E-BP1 by activated mTORC1 (Danio rerio)
REACT:R-DDI-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Dictyostelium discoideum)
RHEA:72533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + methyl beta-D-galactoside(in) + phosphate => ATP + H2O + methyl beta-D-galactoside(out)
RHEA:70432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + Li(+)(in) => 2 H(+)(in) + Li(+)(out)
REACT:R-SCE-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Saccharomyces cerevisiae)
RHEA:17492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + phthalate <=> cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)
REACT:R-PFA-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Plasmodium falciparum)
REACT:R-XTR-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Xenopus tropicalis)
REACT:R-MMU-5205681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is cleaved on healthy mitochondria (Mus musculus)
REACT:R-SSC-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Sus scrofa)
REACT:R-BTA-9023968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Bos taurus)
GO:1904931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM complex binding
GO:1904931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mini-chromosome maintenance complex binding
REACT:R-DDI-5689111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 autoubiquitinates (Dictyostelium discoideum)
EC:3.4.21.75	skos:altLabel	"paired basic amino acid residue cleaving enzyme"
EC:3.4.21.75	skos:altLabel	"prohormone convertase"
EC:3.4.21.75	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"furin"
EC:3.4.21.75	skos:altLabel	"dibasic processing enzyme"
EC:3.4.21.75	skos:prefLabel	"furin"
REACT:R-CFA-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Canis familiaris)
REACT:R-CEL-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Caenorhabditis elegans)
REACT:R-CFA-5225649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP7 binds histone H3 (Canis familiaris)
GO:0034889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endosulfan hemisulfate sulfatase activity
REACT:R-DDI-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Dictyostelium discoideum)
REACT:R-HSA-997237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B proteins bind JAK2 (Homo sapiens)
REACT:R-BTA-190265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds to FGF (Bos taurus)
GO:0102899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroabietadienol hydroxylase activity
RHEA:17689	skos:altLabel	"BAST"
RHEA:17689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)
RHEA:17689	skos:prefLabel	"glycochenodeoxycholate sulfotransferase"
RHEA:17689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycochenodeoxycholate sulfotransferase"
RHEA:17689	skos:altLabel	"bile acid:PAPS:sulfotransferase"
RHEA:17689	skos:altLabel	"bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase"
RHEA:57658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GT1balpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b
REACT:R-HSA-9694677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA (Homo sapiens)
REACT:R-HSA-5625574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ (Homo sapiens)
REACT:R-PFA-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Plasmodium falciparum)
REACT:R-PFA-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
RHEA:69753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA + CO2 + H2O2 => benzylmalonyl-CoA + H(+) + O2
RHEA:71246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + hypotaurine(out) + 2 Na(+)(out) <=> chloride(in) + hypotaurine(in) + 2 Na(+)(in)
RHEA:46668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone + H(+) + NADPH = 5beta-dihydrodeoxycorticosterone + NADP(+)
REACT:R-DRE-5244692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Danio rerio)
RHEA:40938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)
REACT:R-HSA-1497869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)
REACT:R-SPO-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Schizosaccharomyces pombe)
RHEA:27575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-piperidine-3-carboxamide + H2O => (3R)-piperidine-3-carboxylate + NH4(+)
RHEA:54916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH
REACT:R-SSC-166538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The bound receptor dimerizes (Sus scrofa)
REACT:R-GGA-2855125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-1 binds to molecular patterns on the target cell surface (Gallus gallus)
REACT:R-SSC-6788392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Sus scrofa)
REACT:R-BTA-170847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Bos taurus)
REACT:R-SSC-5693148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDK phosphorylates BCKDH (Sus scrofa)
RHEA:34868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + thiophene-2-carboxylate => AMP + diphosphate + thiophene-2-carbonyl-CoA
REACT:R-HSA-5690790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)
GO:0018738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-formylglutathione hydrolase activity
REACT:R-DRE-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Danio rerio)
GO:0005047	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	docking protein
GO:0005047	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	signal recognition particle receptor
GO:0005047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signal recognition particle binding
REACT:R-BTA-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Bos taurus)
REACT:R-HSA-450333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
REACT:R-GGA-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Gallus gallus)
REACT:R-BTA-5654592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)
RHEA:47421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + glutaryl-CoA => (2E)-glutaconyl-CoA + AH2
RHEA:61934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-miconazole(out) + ADP + H(+) + phosphate => (S)-miconazole(in) + ATP + H2O
REACT:R-DRE-1602374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Danio rerio)
REACT:R-RNO-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)
REACT:R-RNO-71324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)
REACT:R-XTR-389532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A binds CTLA4 dimer (Xenopus tropicalis)
RHEA:65867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androst-1-ene-3,17-dione + A + H2O <=> 5alpha-androstan-1,3,17-trione + AH2
REACT:R-XTR-5617037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Xenopus tropicalis)
REACT:R-MMU-8875902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC45A3 transports Glc from extracellular region to cytosol (Mus musculus)
REACT:R-HSA-380278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Homo sapiens)
REACT:R-DRE-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Danio rerio)
RHEA:28479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate(in) + H(+)(in) => galactarate(out) + H(+)(out)
RHEA:34092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-phosphooxy-L-lysine + H2O => (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate
REACT:R-HSA-1606561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)
REACT:R-DRE-2424252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds collagen, fibronectin, aggrecan and matrilins (Danio rerio)
REACT:R-MMU-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Mus musculus)
RHEA:57821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + ADP => [phosphate](n+1) + AMP
RHEA:20348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + NADP(+) <=> [thioredoxin]-disulfide + H(+) + NADPH
REACT:R-SCE-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Saccharomyces cerevisiae)
REACT:R-HSA-9009309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STUB1 (Homo sapiens)
RHEA:61169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP
REACT:R-XTR-193679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-secretase cleaves the p75NTR extracellular domain (Xenopus tropicalis)
REACT:R-XTR-1606807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Xenopus tropicalis)
REACT:R-SPO-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Schizosaccharomyces pombe)
REACT:R-RNO-2076419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Rattus norvegicus)
GO:0102342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-cerotoyl-CoA reductase activity
REACT:R-PFA-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Plasmodium falciparum)
REACT:R-RNO-266303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds C and E apolipoproteins (Rattus norvegicus)
REACT:R-DRE-418091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB1 (Danio rerio)
REACT:R-XTR-74716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin binds the insulin receptor (Xenopus tropicalis)
REACT:R-HSA-8854303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D11 binds RAB6 (Homo sapiens)
REACT:R-SCE-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)
RHEA:55262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:43587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + iminoarginine <=> 5-guanidino-2-oxopentanoate + NH4(+)
REACT:R-PFA-5656158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ elongates POLI-incorporated dNMP (Plasmodium falciparum)
RHEA:64710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + H(+) + NADPH => butan-1-ol + NADP(+)
REACT:R-CFA-451900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RB binds JAK1 (Canis familiaris)
REACT:R-GGA-6801675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates NPM1 (Gallus gallus)
RHEA:12960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acetyl ester + H2O <=> acetate + an aliphatic alcohol + H(+)
RHEA:49937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(1,4)-steroid + AH2
REACT:R-CEL-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)
RHEA:35202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate(out) <=> (S,S)-tartrate(in)
REACT:R-BTA-8950342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBI3:CANX binds IL27 (Bos taurus)
RHEA:62035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O <=> a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)
RHEA:41146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-BTA-1250357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds P-ERBB4 isoform dimers (Bos taurus)
RHEA:53560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Gallus gallus)
RHEA:42982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + phenol => L-tyrosine
REACT:R-DRE-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Danio rerio)
RHEA:31206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hexanoyl-CoA <=> 3-oxooctanoyl-CoA + CoA
REACT:R-XTR-8873834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 transports PC from ER membrane to lamellar body membrane (Xenopus tropicalis)
REACT:R-XTR-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Xenopus tropicalis)
RHEA:48556	skos:altLabel	"beta-ribofuranosylaminobenzene 5'-phosphate synthase"
RHEA:48556	skos:altLabel	"4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase"
RHEA:48556	skos:altLabel	"beta-RFAP synthase"
RHEA:48556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate
RHEA:48556	skos:prefLabel	"beta-ribofuranosylphenol 5'-phosphate synthase"
RHEA:48556	skos:altLabel	"beta-RFA-P synthase"
RHEA:48556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-ribofuranosylphenol 5'-phosphate synthase"
REACT:R-HSA-8851298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR143 binds L-Dopa (Homo sapiens)
REACT:R-CEL-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Caenorhabditis elegans)
RHEA:58889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + AH2 + 2 O2 => 4-nitrobenzoate + A + 2 H2O
RHEA:12854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose => dhurrin + H(+) + UDP
GO:0047712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Cypridina-type luciferase activity
GO:0047712	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	luciferase activity
GO:0047712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)
GO:0047712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Cypridina luciferase activity
GO:0047712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	luciferase (Cypridina luciferin)
GO:0047712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cypridina-luciferin 2-monooxygenase activity
REACT:R-DDI-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Dictyostelium discoideum)
REACT:R-DME-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Drosophila melanogaster)
REACT:R-SSC-508292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds IL2RB (Sus scrofa)
REACT:R-CEL-3928645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB:NMDAR binds TIAM1 (Caenorhabditis elegans)
REACT:R-DME-5658231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs stimulate RAS GTPase activity (Drosophila melanogaster)
RHEA:70691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) + glycine(in) + 2 Na(+)(in)
GO:0047885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesol isomerase activity
GO:0047885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesol 2-isomerase activity
GO:0047885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesol 2-cis-trans-isomerase activity
GO:0047885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol = (2Z,6E)-farnesol
GO:0047885	skos:prefLabel	"farnesol 2-isomerase"
GO:0047885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"farnesol 2-isomerase"
REACT:R-BTA-2730849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT (Bos taurus)
REACT:R-SSC-9762345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDN:ALB dissociates (Sus scrofa)
RHEA:37081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine
REACT:R-CEL-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Caenorhabditis elegans)
RHEA:67279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanal + NAD(+) <=> 2 H(+) + hexanoate + NADH
RHEA:45161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H(+) => acetaldehyde + CO2
RHEA:11304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate = glyoxylate + urea
RHEA:11304	skos:prefLabel	"ureidoglycolate lyase"
RHEA:11304	skos:altLabel	"ureidoglycolase"
RHEA:11304	skos:altLabel	"ureidoglycolatase"
RHEA:11304	skos:altLabel	"ureidoglycolate hydrolase"
RHEA:11304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ureidoglycolate lyase"
REACT:R-RNO-2396079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds Plasminogen activator inhibitor- 1 (Rattus norvegicus)
REACT:R-MMU-199161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fc gamma receptors interact with antigen-bound IgG (Mus musculus)
REACT:R-MMU-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Mus musculus)
RHEA:57238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + methylglyoxal
REACT:R-BTA-9614271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ADGRG6 (Bos taurus)
REACT:R-RNO-352052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Rattus norvegicus)
REACT:R-CFA-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Canis familiaris)
REACT:R-SSC-427514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC deacetylates histone H3 (Sus scrofa)
RHEA:41513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + NADH + O2 => H2O + N(5)-hydroxy-L-ornithine + NAD(+)
REACT:R-SPO-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Schizosaccharomyces pombe)
RHEA:22133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-maltose(out) + H2O => ADP + D-maltose(in) + H(+) + phosphate
GO:0140313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular sequestering activity
REACT:R-SSC-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Sus scrofa)
RHEA:68436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 = (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
REACT:R-DDI-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Dictyostelium discoideum)
REACT:R-SSC-5419273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of GTP and dissociation of 28S and 39S subunits (Sus scrofa)
REACT:R-SPO-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Schizosaccharomyces pombe)
REACT:R-XTR-879411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Xenopus tropicalis)
RHEA:55832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1236964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of peptide bound MHC class I complex to cell surface (Rattus norvegicus)
RHEA:28964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-proline(out) => H(+)(in) + L-proline(in)
REACT:R-HSA-9638125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G1P to G6P (Homo sapiens)
REACT:R-GGA-5682690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 dissociates from ATG12:ATG5 (Gallus gallus)
REACT:R-DRE-373813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR2 binds ligands CXCL1 to 7 (Danio rerio)
RHEA:13029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamine + O2 = H(+) + H2O2 + N-acetyl-D-glucosaminate
GO:0031889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urotensin receptor binding
GO:0031889	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	urotensin receptor ligand
GO:0140522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fusogenic activity
RHEA:66828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate
RHEA:14812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenol + S-adenosyl-L-methionine <=> anisole + H(+) + S-adenosyl-L-homocysteine
RHEA:13677	skos:altLabel	"xylulose phosphate 3-epimerase"
RHEA:13677	skos:altLabel	"pentose-5-phosphate 3-epimerase"
RHEA:13677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribulose-phosphate 3-epimerase"
RHEA:13677	skos:altLabel	"erythrose-4-phosphate epimerase"
RHEA:13677	skos:altLabel	"D-ribulose phosphate-3-epimerase"
RHEA:13677	skos:prefLabel	"ribulose-phosphate 3-epimerase"
RHEA:13677	skos:altLabel	"D-ribulose-5-phosphate epimerase"
RHEA:13677	skos:altLabel	"D-xylulose-5-phosphate 3-epimerase"
RHEA:13677	skos:altLabel	"phosphoribulose epimerase"
RHEA:13677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate = D-xylulose 5-phosphate
RHEA:25392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) => cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH
RHEA:72095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine(out) + Na(+)(out) = (S)-carnitine(in) + Na(+)(in)
RHEA:72311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(in) + taurocholate(out) = glutathione(out) + taurocholate(in)
REACT:R-CFA-5638016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2:ARL3:GDP:UNC119B dissociates (Canis familiaris)
RHEA:34919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine(in) = thiamine(out)
RHEA:36889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2
REACT:R-SSC-388811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-1 homodimer (Sus scrofa)
REACT:R-GGA-933536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7 dimer interacts with coactivator CBP/p300 (Gallus gallus)
REACT:R-HSA-265010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)
RHEA:30013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-galactose(in) + H(+) + phosphate => ATP + beta-D-galactose(out) + H2O
RHEA:13922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-3215251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53INP1 and HIPK2 bind TP53 (Canis familiaris)
REACT:R-CEL-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Caenorhabditis elegans)
REACT:R-BTA-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Bos taurus)
RHEA:42221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
GO:0052582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-menthofuran synthase activity
GO:0052582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P450 menthofuran synthase activity
GO:0052582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	menthofuran synthase activity
GO:0052582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating) activity
GO:0052582	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(+)-MFS activity
GO:0052582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-pulegone 9-hydroxylase activity
RHEA:33749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + ADP + H(+) => a 1-acyl-sn-glycerol + ATP
REACT:R-GGA-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Gallus gallus)
REACT:R-HSA-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Homo sapiens)
REACT:R-SCE-75010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser 216 by Chk1 (Saccharomyces cerevisiae)
REACT:R-HSA-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Homo sapiens)
REACT:R-MMU-446200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLPP1 dephosphorylates DOLDP to DOLP (Mus musculus)
REACT:R-PFA-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-CFA-5591040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves Factor Va intermediate form for Factor Va (Canis familiaris)
GO:0035254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate receptor binding
RHEA:28038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dCDP + H2O = [thioredoxin]-dithiol + CDP
RHEA:47426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(9Z-octadecenoyl)-CoA => (2E,9Z)-octadecadienoyl-CoA + H2O
REACT:R-RNO-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Rattus norvegicus)
REACT:R-RNO-8849345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Rattus norvegicus)
REACT:R-DDI-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Dictyostelium discoideum)
REACT:R-DDI-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Dictyostelium discoideum)
REACT:R-SSC-9021170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen stimulates dimerization of plasma membrane estrogen receptors (Sus scrofa)
REACT:R-DME-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Drosophila melanogaster)
REACT:R-RNO-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
RHEA:27681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dCDP <=> ADP + dCTP
REACT:R-HSA-9717658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 N binds DDX58 (Homo sapiens)
REACT:R-SSC-157849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes containing mRNA that does not circularize (Sus scrofa)
REACT:R-CFA-5693012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF15 binds TNFRSF25 (Canis familiaris)
REACT:R-RNO-2161964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Rattus norvegicus)
REACT:R-XTR-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Xenopus tropicalis)
RHEA:69939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0106399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)
GO:0106399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-coenzyme A diphosphatase activity
REACT:R-HSA-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Homo sapiens)
REACT:R-HSA-351863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active caspase-8 to the mitochondrial membrane (Homo sapiens)
GO:0010542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate efflux transmembrane transporter activity
REACT:R-DME-5654628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS3 (Drosophila melanogaster)
REACT:R-MMU-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Mus musculus)
GO:0102606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octat-9-en-7-ol 5-monooxygenase activity
RHEA:66809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH => 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A
REACT:R-MMU-8847638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Mus musculus)
RHEA:59312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + O2 = D-galactono-1,5-lactone + H2O2
RHEA:61233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine + O2 => (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)
REACT:R-CFA-9708466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y486 BACH1 translocates from the nucleoplasm to the cytosol (Canis familiaris)
RHEA:70617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein] => hexadecanoyl-[ACP] + L-lysyl-[protein]
RHEA:15381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quercetin 2,3-dioxygenase"
RHEA:15381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
RHEA:15381	skos:prefLabel	"quercetin 2,3-dioxygenase"
REACT:R-BTA-109700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT2 binds PIP3 (Bos taurus)
REACT:R-SCE-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Saccharomyces cerevisiae)
REACT:R-CFA-205262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Direct recruitment of PI3K to p-KIT (Canis familiaris)
GO:0004168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichol kinase activity
GO:0004168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:dolichol O-phosphotransferase activity
GO:0004168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol phosphokinase activity
RHEA:18462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
RHEA:44579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) <=> 2-all-trans-nonaprenylphenol + CO2
REACT:R-BTA-9609310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β-blockers bind ADRB1,2,3 (Bos taurus)
RHEA:65526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-9709831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds TBK1 and IRF3 (Xenopus tropicalis)
REACT:R-DRE-8948222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)
GO:0034317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinic acid riboside kinase activity
REACT:R-CFA-9703895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds CASR agonists (Canis familiaris)
REACT:R-MMU-194187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Mus musculus)
RHEA:35364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH => isopentadecanoyl-CoA + NADP(+)
GO:0008391	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2B19
GO:0008391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonic acid monooxygenase activity
REACT:R-CFA-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Canis familiaris)
RHEA:50933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
RHEA:42293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + phosphate => an acyl phosphate + holo-[ACP]
RHEA:12260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NADH = ADP + H(+) + NADPH
RHEA:12260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADH kinase"
RHEA:12260	skos:prefLabel	"NADH kinase"
RHEA:28519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
REACT:R-RNO-6786171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 deubiquitination by USP1:WDR48 (Rattus norvegicus)
EC:1.2.1.90	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyceraldehyde-3-phosphate dehydrogenase [NAD(P)(+)]"
EC:1.2.1.90	skos:altLabel	"GAPN"
EC:1.2.1.90	skos:altLabel	"non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase"
EC:1.2.1.90	skos:prefLabel	"glyceraldehyde-3-phosphate dehydrogenase [NAD(P)(+)]"
REACT:R-HSA-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Homo sapiens)
REACT:R-GGA-9012000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Gallus gallus)
RHEA:55886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[aequorin]--dioxetanone => [aequorin] + 3 Ca(2+)
REACT:R-GGA-217013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members (Gallus gallus)
REACT:R-SSC-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Sus scrofa)
REACT:R-HSA-420127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGRP receptor can bind calcitonin gene-related peptides (Homo sapiens)
RHEA:34147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-L-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate
RHEA:34147	skos:prefLabel	"L-glutamine:2-deoxy-scyllo-inosose aminotransferase"
RHEA:34147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glutamine:2-deoxy-scyllo-inosose aminotransferase"
GO:0050046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lathosterol 5-desaturase activity
GO:0050046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-DES
GO:0050046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta7-sterol 5-desaturase activity
GO:0050046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol oxidase activity
GO:0050046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta7-sterol delta5-dehydrogenase activity
GO:0050046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta7-sterol-C5(6)-desaturase activity
GO:0050046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta7-sterol 5(6)-desaturase activity
REACT:R-HSA-392133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RHEA:51087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid omega-3 desaturase (cytochrome b5)"
RHEA:46404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46404	skos:prefLabel	"acyl-lipid omega-3 desaturase (cytochrome b5)"
REACT:R-DDI-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Dictyostelium discoideum)
REACT:R-BTA-159796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor IX to factor IX (Bos taurus)
RHEA:36665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,5S)-5-carboxymethylproline + CO2 + CoA => (S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA
REACT:R-SCE-450550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCalpha phosphorylates HuR (Saccharomyces cerevisiae)
RHEA:26294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'S)-averufin + NADPH + O2 => 1'-hydroxyversicolorone + H2O + NADP(+)
RHEA:50813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Rattus norvegicus)
REACT:R-HSA-1678660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan sulfate chain(3) (Homo sapiens)
REACT:R-BTA-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Bos taurus)
REACT:R-HSA-349404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Homo sapiens)
REACT:R-DRE-6807578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface in the phagosome (Danio rerio)
RHEA:32330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxy-alpha-humulene + NAD(+) <=> H(+) + NADH + zerumbone
REACT:R-BTA-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Bos taurus)
REACT:R-DDI-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Dictyostelium discoideum)
RHEA:43770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(5)-alkyl-L-glutaminyl-[protein] + NH4(+) => an alkylamine + L-glutaminyl-[protein]
RHEA:58165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 2 H2O => 7-epi-ent-eudesmane-5,11-diol + diphosphate
REACT:R-XTR-912685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBP43 binds IFNAR2 and prevents JAK1 interaction (Xenopus tropicalis)
REACT:R-SSC-158860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates NHABP (Sus scrofa)
RHEA:72565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(in) + dehydroepiandrosterone 3-sulfate(out) => butanoate(out) + dehydroepiandrosterone 3-sulfate(in)
RHEA:52960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-GGA-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)
REACT:R-DRE-352029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Danio rerio)
REACT:R-DDI-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Dictyostelium discoideum)
REACT:R-SSC-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Sus scrofa)
REACT:R-HSA-352232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)
RHEA:19574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + ATP => [phosphate](n+1) + ADP
RHEA:62689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 norrubrofusarin + O2 => 2 H2O + 2 ustilaginoidin A
REACT:R-RNO-6795667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the cytosol (Rattus norvegicus)
RHEA:67147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + jasmonate + O2 <=> (1R,2R)-12-hydroxyjasmonate + CO2 + succinate
RHEA:48906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-XTR-450984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Xenopus tropicalis)
REACT:R-MMU-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Mus musculus)
RHEA:62763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DDI-8942208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOXE3 isomerises 12R-HpETE to HXA3 (Dictyostelium discoideum)
RHEA:70689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in) => 4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out)
RHEA:38717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + choline(in) + H(+) + phosphate => ATP + choline(out) + H2O
RHEA:28292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,9S,10S)-drim-7-en-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-DRE-5626981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Danio rerio)
REACT:R-DME-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Drosophila melanogaster)
RHEA:65688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine
RHEA:62635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxide + 2 glutathione <=> an alcohol + glutathione disulfide + H2O
REACT:R-SSC-6814374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kazrin binds periplakin (Sus scrofa)
REACT:R-HSA-9611368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
REACT:R-BTA-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Bos taurus)
REACT:R-CEL-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Caenorhabditis elegans)
REACT:R-MMU-983421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Journey of cargo through Golgi complex (Mus musculus)
RHEA:46158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9',15-tri-cis-zeta-carotene + a plastoquinol => 15,9'-di-cis-phytofluene + a plastoquinone
REACT:R-GGA-549241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Gallus gallus)
REACT:R-DME-5618105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)
RHEA:35819	skos:altLabel	"dihydromethanopterin reductase"
RHEA:35819	skos:prefLabel	"dihydromethanopterin reductase [NAD(P)(+)]"
RHEA:35819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + NAD(+) = 7,8-dihydromethanopterin + H(+) + NADH
RHEA:35819	skos:altLabel	"H2MPT reductase"
RHEA:35819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydromethanopterin reductase [NAD(P)(+)]"
RHEA:35819	skos:altLabel	"5,6,7,8-tetrahydromethanopterin 5,6-oxidoreductase"
RHEA:35819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + NADP(+) = 7,8-dihydromethanopterin + H(+) + NADPH
REACT:R-HSA-1225960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
REACT:R-GGA-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Gallus gallus)
GO:0005048	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leader sequence binding
GO:0005048	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein signal sequence binding
GO:0005048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signal sequence binding
GO:0005048	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	signal sequence receptor
RHEA:60483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 UTP <=> c-di-UMP + 2 diphosphate
RHEA:32726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-110360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to the AP site (Bos taurus)
RHEA:29583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(in) + H(+)(out) = guanosine(out) + H(+)(in)
REACT:R-HSA-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Homo sapiens)
REACT:R-XTR-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Xenopus tropicalis)
REACT:R-SCE-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)
RHEA:20922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dichlorocatechol + H2O + NADP(+) => 2,4-dichlorophenol + H(+) + NADPH + O2
RHEA:18992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-valine <=> 2-methylpropan-1-amine + CO2
REACT:R-HSA-9023840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HATs and coactivators are recruited to the CTSD gene (Homo sapiens)
RHEA:41154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)
RHEA:13331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(1)-steroid + AH2 => A + a 3-oxosteroid
REACT:R-CFA-74220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Canis familiaris)
REACT:R-MMU-1855171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Mus musculus)
REACT:R-BTA-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Bos taurus)
REACT:R-BTA-8875183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates activated MET (Bos taurus)
RHEA:39303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA = (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O
REACT:R-RNO-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Rattus norvegicus)
RHEA:45913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)
REACT:R-DRE-3640861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 ubiquitinates ADP-ribosylated AXIN (Danio rerio)
REACT:R-DME-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Drosophila melanogaster)
REACT:R-BTA-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Bos taurus)
RHEA:62817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 monapinone E + O2 => 2 dinapinone E + 2 H2O
REACT:R-CEL-8950778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dimerizes (Caenorhabditis elegans)
REACT:R-BTA-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Bos taurus)
RHEA:53163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-sn-glycero-3-phosphoethanolamine <=> an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate
REACT:R-RNO-8874083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y397-PTK2 binds SRC (Rattus norvegicus)
GO:0030788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine--precorrin-2 methyltransferase activity
GO:0030788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-2 C20-methyltransferase activity
GO:0030788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity
RHEA:45622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine => H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-DME-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Drosophila melanogaster)
REACT:R-HSA-6805109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates TP53 (Homo sapiens)
REACT:R-RNO-9679045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR9 dimer binds HCQ (Rattus norvegicus)
RHEA:17554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanidinoethyl methyl phosphate => ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate
GO:0008662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-1-phosphate kinase activity
GO:0008662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphofructokinase 1
GO:0008662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phosphofructokinase (phosphorylating)
GO:0008662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 1-phosphate kinase activity
GO:0008662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-fructose-phosphate 6-phosphotransferase activity
GO:0008662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose-1-phosphate kinase activity
GO:0008662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphofructokinase activity
RHEA:33077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine
REACT:R-MMU-4420143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SH2D2A (Mus musculus)
RHEA:23581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 => prostaglandin I2
RHEA:17009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"o-succinylbenzoate--CoA ligase"
RHEA:17009	skos:altLabel	"o-succinylbenzoyl-CoA synthetase"
RHEA:17009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate
RHEA:17009	skos:altLabel	"OSB-CoA synthetase"
RHEA:17009	skos:prefLabel	"o-succinylbenzoate--CoA ligase"
GO:0046577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty alcohol oxidase activity
GO:0046577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-alcohol oxidase activity
GO:0046577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain fatty acid oxidase activity
GO:0046577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty alcohol oxidase activity
GO:0046577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty alcohol:oxygen oxidoreductase activity
GO:0046577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-alcohol:oxygen oxidoreductase activity
REACT:R-RNO-140783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Rattus norvegicus)
RHEA:58409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + undecan-1-ol => H(+) + NADPH + undecanal
REACT:R-HSA-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Homo sapiens)
REACT:R-BTA-9686521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2:CCNA phosphorylates TERF2 (Bos taurus)
RHEA:14919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase]
RHEA:34348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + NAD(+) => (2E)-geranial + H(+) + NADH
REACT:R-CFA-1454822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP1,2,8,13, PRSS2 (Canis familiaris)
REACT:R-RNO-265423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Fibrillin (Rattus norvegicus)
RHEA:20589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:21381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,11,15-tetramethylhexadecanoate + ATP + CoA => AMP + diphosphate + phytanoyl-CoA
REACT:R-DRE-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Danio rerio)
RHEA:14325	skos:prefLabel	"o-dihydroxycoumarin 7-O-glucosyltransferase"
RHEA:14325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"o-dihydroxycoumarin 7-O-glucosyltransferase"
RHEA:14325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxycoumarin + UDP-alpha-D-glucose = daphnin + H(+) + UDP
REACT:R-DRE-159836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)
RHEA:22068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH
EC:5.6.1.8	skos:prefLabel	"myosin ATPase"
EC:5.6.1.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"myosin ATPase"
RHEA:52101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)
REACT:R-RNO-2028735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind WWTR1 (TAZ) (Rattus norvegicus)
REACT:R-HSA-5659764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:72374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + succinate(in) <=> dehydroepiandrosterone 3-sulfate(in) + succinate(out)
REACT:R-DDI-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Dictyostelium discoideum)
REACT:R-SPO-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Schizosaccharomyces pombe)
RHEA:59795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + yersinopine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate
REACT:R-SSC-9645442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Sus scrofa)
REACT:R-CEL-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Caenorhabditis elegans)
REACT:R-HSA-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Homo sapiens)
RHEA:68230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(out) + Na(+)(out) => glycine(in) + Na(+)(in)
RHEA:41553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + ophiobolin F
RHEA:10011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + a hydroperoxide <=> [protein]-disulfide + an alcohol + H2O
REACT:R-SSC-202731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM3 dimerises (Sus scrofa)
REACT:R-BTA-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Bos taurus)
GO:0044823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retroviral integrase activity
REACT:R-HSA-173769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers (Homo sapiens)
REACT:R-XTR-5696997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP24 deubiquitinates DDB2 (Xenopus tropicalis)
REACT:R-BTA-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Bos taurus)
RHEA:51929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) => (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH
REACT:R-DME-8877192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds FOXP3 (Drosophila melanogaster)
REACT:R-RNO-3781024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Rattus norvegicus)
REACT:R-DME-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Drosophila melanogaster)
RHEA:52750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 isomaltose => alpha-isomaltosyl-(1->3)-isomaltose + H2O
RHEA:71900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide
RHEA:40033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ent-manool => ent-copalyl diphosphate + H2O
RHEA:51114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-8854466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds RELN (Homo sapiens)
REACT:R-BTA-76475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Bos taurus)
REACT:R-XTR-194689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
RHEA:17345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-methylmalonyl-CoA hydrolase"
RHEA:17345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + H2O = CoA + H(+) + methylmalonate
RHEA:17345	skos:prefLabel	"(S)-methylmalonyl-CoA hydrolase"
REACT:R-SSC-170072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Sus scrofa)
RHEA:14922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + UDP-alpha-D-glucose => 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP
REACT:R-CEL-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Caenorhabditis elegans)
RHEA:20726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3E)-enoyl-CoA + H2O => a 4-saturated-(3S)-3-hydroxyacyl-CoA
REACT:R-HSA-5694445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH1 binds TFGA and AREG precursors (Homo sapiens)
RHEA:68849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => diphosphate + gamma-cadinene
REACT:R-DRE-1675473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B binds JAK2 (Danio rerio)
EC:2.4.2.41	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylogalacturonan beta-1,3-xylosyltransferase"
EC:2.4.2.41	skos:altLabel	"XGA xylosyltransferase"
EC:2.4.2.41	skos:altLabel	"xylogalacturonan xylosyltransferase"
EC:2.4.2.41	skos:prefLabel	"xylogalacturonan beta-1,3-xylosyltransferase"
REACT:R-BTA-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Bos taurus)
REACT:R-DME-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Drosophila melanogaster)
REACT:R-BTA-9668597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase:primase binds G-strand of the telomere (Bos taurus)
REACT:R-RNO-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Rattus norvegicus)
RHEA:34741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine
REACT:R-RNO-870269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gastrin binds to CCK-B receptor (Rattus norvegicus)
RHEA:60333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:32032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + gamma-curcumene
REACT:R-BTA-6814409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates PDCL (Bos taurus)
REACT:R-XTR-9667952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 is deacetylated by SIRT2 (Xenopus tropicalis)
REACT:R-CFA-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
GO:0042944	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-alanine transporter activity
GO:0042944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine transmembrane transporter activity
RHEA:26236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol
REACT:R-DRE-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Danio rerio)
RHEA:39968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobut-2-enoate => 2-iminobutanoate
RHEA:33729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine
REACT:R-DDI-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:57215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-dGTP
REACT:R-GGA-2130641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TGN-lysosome vesicle to lysosome (Gallus gallus)
REACT:R-RNO-9007539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates E2F6 (Rattus norvegicus)
REACT:R-SPO-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Schizosaccharomyces pombe)
REACT:R-MMU-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
RHEA:33456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxyzymosterol + NADP(+) => CO2 + NADPH + zymosterone
RHEA:35966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A <=> fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA precursor + 2 CTP = a tRNA with a 3' CC end + 2 diphosphate
RHEA:49470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose
RHEA:44954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADPH
GO:0018567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	styrene dioxygenase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	new coccine (NC)-reductase
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:4-(dimethylamino)azobenzene oxidoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	orange II azoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-aminoazobenzene reductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dibromopropylaminophenylazobenzoic azoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2-dependent azoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	New coccine (NC)-reductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-dimethylaminoazobenzene azoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	azobenzene reductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylaminobenzene reductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methyl red azoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADPH-dependent azoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	orange I azoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethyl-4-phenylazoaniline azoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	azoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	azo reductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NC-reductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	azo-dye reductase activity
GO:0050446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide (phosphate) azoreductase activity
GO:0005521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lamin binding
GO:0005521	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lamin/chromatin binding
REACT:R-DRE-1606602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Danio rerio)
REACT:R-MMU-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Mus musculus)
REACT:R-SSC-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Sus scrofa)
REACT:R-XTR-9013284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3-ligand complex is cleaved to produce NEXT3 (Xenopus tropicalis)
REACT:R-HSA-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Homo sapiens)
RHEA:60400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine
REACT:R-CFA-4085029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU2 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)
RHEA:61388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin(in) + H2O = ADP + biotin(out) + H(+) + phosphate
REACT:R-MMU-5578883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Mus musculus)
GO:0031925	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyridoxal transporter activity
GO:0031925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal transmembrane transporter activity
RHEA:23089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-alkylglycerone => 1-O-alkylglycerone 3-phosphate + ADP + H(+)
REACT:R-RNO-2395879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
RHEA:57341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine
RHEA:63941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine
RHEA:72060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate(out) + 2 Na(+)(out) => glycochenodeoxycholate(in) + 2 Na(+)(in)
RHEA:24641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosteryl 3-beta-D-glucoside + H2O => D-glucose + ergosterol
REACT:R-DME-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
REACT:R-DRE-8848023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds STAP2 (Danio rerio)
RHEA:11287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymalonate + NAD(+) <=> H(+) + NADH + oxomalonate
GO:0102382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside B glucosyltransferase activity
REACT:R-MMU-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Mus musculus)
RHEA:15636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + O2 <=> 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)
GO:0140613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate
GO:0140613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type manganese transporter activity
GO:0140613	skos:altLabel	"Mn(II)-translocating P-type ATPase"
GO:0140613	skos:prefLabel	"P-type Mn(2+) transporter"
GO:0140613	skos:altLabel	"Mn(2+)-exporting ATPase"
GO:0140613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type Mn(2+) transporter"
REACT:R-CEL-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Caenorhabditis elegans)
RHEA:61588	skos:prefLabel	"amicoumacin kinase"
RHEA:61588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amicoumacin A + ATP = ADP + amicoumacin A 2-phosphate + H(+)
RHEA:61588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amicoumacin kinase"
EC:4.2.1.165	skos:prefLabel	"chlorophyllide a 3(1)-hydratase"
EC:4.2.1.165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorophyllide a 3(1)-hydratase"
RHEA:32600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => 3-isopropenyl-6-oxoheptanoate + H(+)
REACT:R-MMU-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Mus musculus)
REACT:R-CFA-8874078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Canis familiaris)
RHEA:54866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpent-3-en-1-yl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + sulcatone
RHEA:14194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + AH2 + O2 => 2,3-dihydroxybenzoate + A + H2O
RHEA:61157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + GTP => CoA + GDP + H(+)
REACT:R-MMU-3781024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Mus musculus)
REACT:R-SSC-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Sus scrofa)
RHEA:69639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phlorizin = beta-D-glucose + phloretin
REACT:R-BTA-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Bos taurus)
REACT:R-DRE-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)
REACT:R-DDI-1855169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
REACT:R-DME-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Drosophila melanogaster)
REACT:R-GGA-391168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP gamma binds CD47 (Gallus gallus)
REACT:R-MMU-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Mus musculus)
REACT:R-CFA-8853419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 promotes AURKA autophosphorylation (Canis familiaris)
REACT:R-HSA-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)
REACT:R-DME-9652580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Drosophila melanogaster)
REACT:R-SSC-3240295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Sus scrofa)
RHEA:27907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + NADP(+) => (2E)-butenoyl-CoA + H(+) + NADPH
RHEA:34186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose <=> alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine endopeptidase activity
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proteasome endopeptidase complex
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prosome
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	26S protease
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Threonine endopeptidases"
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multicatalytic endopeptidase complex
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkaline protease
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	large multicatalytic protease
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lens neutral proteinase
GO:0004298	skos:prefLabel	"Threonine endopeptidases"
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ingensin
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MCP
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	multicatalytic proteinase
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tricorn proteinase
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine-type endopeptidase activity
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	multicatalytic proteinase (complex)
GO:0004298	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tricorn protease
RHEA:51194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + NADPH => (R)-2-hydroxyglutarate + NADP(+)
REACT:R-GGA-4719413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO2 (Gallus gallus)
RHEA:55197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal
REACT:R-CEL-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Caenorhabditis elegans)
RHEA:72413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O => inulobiose
REACT:R-DME-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Drosophila melanogaster)
REACT:R-HSA-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)
REACT:R-CFA-3858482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is recruited to the receptor (Canis familiaris)
RHEA:63319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> 9-hydroperoxy-(10E,12Z)-octadecadienoate
RHEA:42031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + ursodeoxycholate <=> 7-oxolithocholate + H(+) + NADH
GO:0033939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-(1->2)-glucuronidase activity
GO:0033939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-alpha-glucuronidase activity
GO:0033939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylan alpha-1,2-glucuronosidase activity
GO:0033939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity
RHEA:43790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate => acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O
REACT:R-HSA-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Homo sapiens)
RHEA:46416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-[acyl-carrier-protein] 6-desaturase"
RHEA:46416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:46416	skos:prefLabel	"acyl-[acyl-carrier-protein] 6-desaturase"
GO:0047097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phylloquinone monooxygenase (2,3-epoxidizing)"
GO:0047097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin K 2,3-epoxidase activity
GO:0047097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)
GO:0047097	skos:altLabel	"phylloquinone epoxidase"
GO:0047097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O
GO:0047097	skos:prefLabel	"phylloquinone monooxygenase (2,3-epoxidizing)"
GO:0047097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phylloquinone monooxygenase (2,3-epoxidizing) activity
GO:0047097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phylloquinone epoxidase activity
GO:0047097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin K epoxidase activity
GO:0047097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin K1 epoxidase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:potassium-exchanging ATPase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Na+/K+-exchanging ATPase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Na+,K+-ATPase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/potassium-exchanging ATPase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Na(+)/K(+)-ATPase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium pump
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type sodium:potassium-exchanging transporter activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type sodium:potassium-exchanging ATPase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Na,K-activated ATPase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/potassium-transporting ATPase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Na+/K+-ATPase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:potassium exchanging ATPase activity
GO:0005391	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Na(+)/K(+)-exchanging ATPase activity
REACT:R-MMU-380927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK phosphorylates TSC1:TSC2 (Mus musculus)
GO:0044549	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GTP cyclohydrolase I binding
GO:0044549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP cyclohydrolase binding
GO:0140296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	general transcription initiation factor binding
RHEA:27278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH
RHEA:45252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetradecanoate(out) = tetradecanoate(in)
REACT:R-DRE-5250938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Danio rerio)
RHEA:23599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NAD(+) + UDP-alpha-D-glucose <=> 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate
REACT:R-RNO-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Rattus norvegicus)
RHEA:42145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine
REACT:R-HSA-449958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:IL7R:JAK1 binds IL2RG:JAK3 (Homo sapiens)
RHEA:71915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) + tauronorcholate(in)
REACT:R-DME-629588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Drosophila melanogaster)
REACT:R-XTR-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Xenopus tropicalis)
RHEA:48834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:33413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl alpha-D-glucosaminide + acetate => (S)-malyl N-acetyl-alpha-D-glucosaminide + H2O
REACT:R-XTR-8855237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Xenopus tropicalis)
REACT:R-SSC-8985343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SOX9 (Sus scrofa)
REACT:R-SSC-1236954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides by IRAP in endocytic vesicles (Sus scrofa)
REACT:R-GGA-8952716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 binds Ragulator:Rag dimers (Gallus gallus)
REACT:R-SSC-5649708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 recruits POLB to incised AP site (Sus scrofa)
REACT:R-BTA-5606996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds activated protein C (Bos taurus)
REACT:R-SSC-9621179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cinaciguat binds sGC:NO (Sus scrofa)
REACT:R-GGA-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Gallus gallus)
RHEA:44361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxy-3,4-dioxopentyl phosphate => 3-hydroxy-2,4-dioxopentyl phosphate
REACT:R-RNO-3465545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Rattus norvegicus)
RHEA:50307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-2-aminohexanoate => 2-oxohexanoate + L-glutamate
REACT:R-HSA-2466828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RBP4 does not bind atROL (Homo sapiens)
EC:3.4.11.15	skos:altLabel	"aminopeptidase (cobalt-activated)"
EC:3.4.11.15	skos:altLabel	"aminopeptidase Co"
EC:3.4.11.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminopeptidase Y"
EC:3.4.11.15	skos:altLabel	"lysyl aminopeptidase"
EC:3.4.11.15	skos:prefLabel	"aminopeptidase Y"
GO:0035651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-3 adaptor complex binding
REACT:R-HSA-9756156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes ATV to ATVL (Homo sapiens)
RHEA:18586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate
RHEA:68956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + scopoletin = H(+) + S-adenosyl-L-homocysteine + scoparone
RHEA:49735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O2 + violaceinate <=> CO2 + H2O + violacein
RHEA:68928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + heptanoate + NADPH = AMP + diphosphate + heptanal + NADP(+)
RHEA:12909	skos:prefLabel	"nitrate reductase (cytochrome)"
RHEA:12909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrate reductase (cytochrome)"
RHEA:12909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome] + 2 H(+) + nitrate = 2 Fe(III)-[cytochrome] + H2O + nitrite
RHEA:33131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate = 3-phenylpyruvate + tetrahydrotyrosine
GO:0102362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esculetin 3-O-glucosyltransferase activity
RHEA:51861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + umbelliferone => 8-geranylumbelliferone + diphosphate
REACT:R-SSC-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Sus scrofa)
RHEA:47652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 1-phosphate + H2O = phosphate + ribitol
RHEA:15029	skos:prefLabel	"mannitol dehydrogenase"
RHEA:15029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannitol dehydrogenase"
RHEA:15029	skos:altLabel	"MTD"
RHEA:15029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + NAD(+) = D-mannose + H(+) + NADH
RHEA:15029	skos:altLabel	"NAD-dependent mannitol dehydrogenase"
RHEA:52020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = A + H2O + resolvin E2
RHEA:67523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-SCE-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
REACT:R-DRE-5205820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)
REACT:R-BTA-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Bos taurus)
RHEA:34107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H(+) + hexadecanoyl-CoA = 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA
REACT:R-CFA-391941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLT receptors can bind LTB4 (Canis familiaris)
RHEA:43807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol
REACT:R-XTR-212263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 trimethylates histone H3 at lysine-27 (Xenopus tropicalis)
REACT:R-SSC-194678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 demethylates LNSOL (Sus scrofa)
REACT:R-HSA-1474196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP14 (Homo sapiens)
REACT:R-SSC-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)
REACT:R-HSA-2022396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-43) (Homo sapiens)
REACT:R-SSC-5625717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PKN1 binds androgen receptor (AR) (Sus scrofa)
REACT:R-XTR-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Xenopus tropicalis)
REACT:R-DME-5654714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
RHEA:41560	skos:prefLabel	"(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase"
RHEA:41560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase"
RHEA:41560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O
GO:0000009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,6-mannosyltransferase activity
GO:0000009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-alpha-mannosyltransferase activity
RHEA:65015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-AMP + holo-[ACP] <=> AMP + decanoyl-[ACP] + H(+)
RHEA:23895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitropropanoate + NADP(+) <=> 3-nitroacrylate + H(+) + NADPH
RHEA:59324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + O2 = D-xylono-1,5-lactone + H2O2
REACT:R-RNO-9705738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)
REACT:R-HSA-381158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)
REACT:R-RNO-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Rattus norvegicus)
RHEA:70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]
RHEA:11401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-6-deoxy-alpha-D-altrose + sordaricin => 4'-O-demethylsordarin + GDP + H(+)
RHEA:42202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-dehydrocorticosterone + H(+) + NADPH => corticosterone + NADP(+)
RHEA:25865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine
RHEA:47825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + octadecanoyl-[ACP] => 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-BTA-9011952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Bos taurus)
RHEA:50439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H1 <=> prostaglandin E1
REACT:R-HSA-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Homo sapiens)
REACT:R-SSC-8983996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Sus scrofa)
REACT:R-DME-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Drosophila melanogaster)
REACT:R-DRE-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Danio rerio)
REACT:R-HSA-5666070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Homo sapiens)
RHEA:61575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoate + O2 <=> (15S)-hydroperoxy-(11Z,13E)-eicosadienoate
REACT:R-CEL-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Caenorhabditis elegans)
REACT:R-BTA-389652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Bos taurus)
RHEA:62127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + GTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + GDP
REACT:R-DRE-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Danio rerio)
REACT:R-BTA-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Bos taurus)
REACT:R-HSA-5603208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective OPLAH does not hydrolyse OPRO (Homo sapiens)
RHEA:17666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + octanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]
RHEA:35604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1-phosphate + H2O => D-fructose + phosphate
REACT:R-CFA-1604731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP3 (Canis familiaris)
RHEA:13847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxopropanoate + CO2 => dihydroxyfumarate + H(+)
RHEA:54623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + eicosanoyl-CoA + O2 <=> 2-hydroxyeicosanoyl-CoA + CO2 + succinate
REACT:R-MMU-9026780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)
REACT:R-BTA-6786155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLN binds ICL-DNA (Bos taurus)
RHEA:39958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)
REACT:R-BTA-3296126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Bos taurus)
REACT:R-MMU-173745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3(H2O)-bound Factor B (Mus musculus)
REACT:R-MMU-9023617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrylcholinesterase hydrolyzes acyl Ghrelin (Mus musculus)
REACT:R-GGA-5654655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PPTN11 (Gallus gallus)
REACT:R-MMU-5362386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Hh (Mus musculus)
REACT:R-BTA-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Bos taurus)
RHEA:69175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] <=> (2E)-2-butenoate + L-lysyl-[protein]
RHEA:65853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(1)-steroid + H2O => a 1-hydroxy-3-oxo steroid
RHEA:22259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a 3-oxoacyl-CoA + H(+) + NADPH
REACT:R-GGA-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Gallus gallus)
REACT:R-XTR-200326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CK octamer] (Xenopus tropicalis)
RHEA:12957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylesterase"
RHEA:12957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+)
RHEA:12957	skos:altLabel	"C-esterase (in animal tissues)"
RHEA:12957	skos:prefLabel	"acetylesterase"
REACT:R-SSC-5625738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Sus scrofa)
RHEA:36166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate <=> ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate
RHEA:39998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylethanolamine + H2O <=> a fatty acid + ethanolamine
REACT:R-XTR-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Xenopus tropicalis)
RHEA:34196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 => 2 aureusidin 6-O-beta-glucoside + 2 H2O
RHEA:63018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+) => (5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O
REACT:R-HSA-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Homo sapiens)
REACT:R-HSA-1912385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated NICD1 binds FBXW7 (Homo sapiens)
RHEA:38079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
GO:0004586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine decarboxylase activity
GO:0004586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ornithine carboxy-lyase (putrescine-forming)
GO:0004586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Homo sapiens)
GO:0004586	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-ornithine carboxy-lyase activity
GO:0004586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SpeC
RHEA:28032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + GDP => [thioredoxin]-disulfide + dGDP + H2O
REACT:R-HSA-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Homo sapiens)
REACT:R-HSA-2130378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex to plasma membrane (Homo sapiens)
RHEA:34866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2,3-didehydroadipyl-CoA + H2O <=> 3-hydroxyadipyl-CoA
REACT:R-CEL-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Caenorhabditis elegans)
RHEA:26304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) <=> (S)-allantoin + CO2
GO:0018772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trioxoheptanoate hydrolase activity
REACT:R-BTA-1358792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates activated ERBB3 (Bos taurus)
RHEA:19834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)
GO:0016623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor
GO:0016623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
GO:0016623	skos:prefLabel	"With oxygen as acceptor"
RHEA:10634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannuronate + H(+) + NADH => D-mannonate + NAD(+)
RHEA:51737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-SCE-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Saccharomyces cerevisiae)
RHEA:65265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypentacecilide A + A => AH2 + chrodrimanin C
RHEA:21359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NAD(+) <=> H(+) + L-ribulose + NADH
REACT:R-SSC-77340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Sus scrofa)
REACT:R-RNO-9033959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Rattus norvegicus)
RHEA:64323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + cholesterol <=> cholesteryl (9Z)-hexadecenoate + CoA
RHEA:51590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-pyridoxolactone + H(+) + NADH => isopyridoxal + NAD(+)
REACT:R-DME-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Drosophila melanogaster)
REACT:R-CFA-193965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 18HCORST to ALDO (Canis familiaris)
RHEA:27631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylene glycol + NAD(+) => glycolaldehyde + H(+) + NADH
RHEA:37718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine <=> 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Canis familiaris)
REACT:R-HSA-8940309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PERM1 (Homo sapiens)
RHEA:16323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indan-1-one + NADPH => (S)-indan-1-ol + NADP(+)
REACT:R-MMU-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Mus musculus)
REACT:R-HSA-3465429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
REACT:R-SCE-3322009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Saccharomyces cerevisiae)
RHEA:11101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyhexan-3-one => 2 propanal
RHEA:72474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + D-threo-isocitrate(in) <=> citrate(in) + D-threo-isocitrate(out)
GO:1990825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence-specific mRNA binding
RHEA:31004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => germanicol
RHEA:61982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + ubiquinol-10 => H(+) + NADPH + ubiquinone-10
REACT:R-HSA-3132737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate ETS1 and ETS2 (Homo sapiens)
REACT:R-RNO-1678742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses Heparan sulfate chain(4) (Rattus norvegicus)
REACT:R-GGA-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Gallus gallus)
REACT:R-DRE-1564164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type V degradation by MMP2,9,10 (Danio rerio)
RHEA:69051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexano-6-lactone <=> 6-hydroxyhexanoate + H(+)
RHEA:34285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-dopa => 2 L-tyrosine + O2
RHEA:65425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + NAD(+)(out) => AMP(out) + NAD(+)(in)
REACT:R-SSC-5138432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 is phosphorylated by PKC (Sus scrofa)
RHEA:64085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) => 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2
RHEA:44969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA + H(+) + NADPH => NADP(+) + tetradecanoyl-CoA
REACT:R-DRE-9649963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC3 channel blockers bind ASIC3 trimer (Danio rerio)
REACT:R-BTA-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)
REACT:R-DME-9632182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates ESRs (Drosophila melanogaster)
RHEA:59725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaono-1,5-lactone + H2O => D-maltoheptaonate + H(+)
RHEA:63759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavokermesate + UDP-alpha-D-glucose <=> flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP
RHEA:53181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose => D-erythrulose
RHEA:66383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate
REACT:R-HSA-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Homo sapiens)
REACT:R-XTR-192051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)
REACT:R-HSA-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)
REACT:R-SSC-5625870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)
REACT:R-HSA-8987266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Homo sapiens)
REACT:R-SSC-4420121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate PLCG1 (Sus scrofa)
REACT:R-CFA-190388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3c (Canis familiaris)
GO:0071796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K6-linked polyubiquitin modification-dependent protein binding
REACT:R-MMU-6786124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3,STAT6 bind p-Y-IL4R (Mus musculus)
REACT:R-HSA-1368133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of RORA (ROR-alpha) (Homo sapiens)
REACT:R-HSA-6786050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Homo sapiens)
REACT:R-GGA-8858346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMHR2 binds AMH (Gallus gallus)
REACT:R-MMU-4546386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO1 (Mus musculus)
REACT:R-SSC-176298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of claspin (Sus scrofa)
GO:0090581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity
RHEA:47406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)
REACT:R-DME-77338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Drosophila melanogaster)
RHEA:41121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-MMU-173545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Mus musculus)
REACT:R-BTA-4724284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Bos taurus)
REACT:R-DME-4551738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO2,3 (Drosophila melanogaster)
REACT:R-DME-8937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)
RHEA:61043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Bos taurus)
REACT:R-HSA-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Homo sapiens)
RHEA:39125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O
REACT:R-SPO-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Schizosaccharomyces pombe)
REACT:R-GGA-2424482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p85 regulatory unit of PI3K binds p-6Y-SYK (Gallus gallus)
RHEA:49515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(phosphinatomethylidene)butanedioate + H2O <=> phosphinomethylisomalate
RHEA:32710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (2R,4S)-bornyl diphosphate
REACT:R-SPO-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Schizosaccharomyces pombe)
GO:0004420	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	HMG-CoA reductase activity
GO:0004420	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-hydroxy-3-methylglutaryl-coenzyme A reductase activity
GO:0004420	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl-CoA reductase activity
GO:0004420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylglutaryl-CoA reductase (NADPH) activity
RHEA:72924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III
RHEA:39483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)
REACT:R-XTR-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Xenopus tropicalis)
REACT:R-HSA-2426355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTN4 binds laminins with gamma-1, gamma-3 (Homo sapiens)
RHEA:10345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-9698932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of HCMV Procapsid (Homo sapiens)
REACT:R-SPO-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Schizosaccharomyces pombe)
RHEA:71873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxybutanoate(in) + H(+)(in) => (S)-3-hydroxybutanoate(out) + H(+)(out)
REACT:R-MMU-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Mus musculus)
RHEA:30192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + plastoquinone-9 => 15,9'-di-cis-phytofluene + plastoquinol-9
REACT:R-HSA-9727293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 localizes to the nuclear envelope (Homo sapiens)
RHEA:45959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA(in) <=> (9Z)-octadecenoyl-CoA(out)
REACT:R-RNO-2022368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-42) (Rattus norvegicus)
REACT:R-DDI-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Dictyostelium discoideum)
REACT:R-MMU-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Mus musculus)
RHEA:51986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)
GO:0009044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-D-xylan xylohydrolase activity
GO:0009044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-xylopyranosidase activity
GO:0009044	skos:altLabel	"1,4-beta-D-xylan xylohydrolase"
GO:0009044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylan 1,4-beta-xylosidase activity
GO:0009044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylan 1,4-beta-xylosidase"
GO:0009044	skos:prefLabel	"xylan 1,4-beta-xylosidase"
GO:0009044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-xylosidase activity
GO:0009044	skos:altLabel	"beta-xylosidase"
GO:0009044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,4-xylosidase activity
GO:0009044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,4-beta-D-xylosidase activity
GO:0009044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,4-beta-xylosidase activity
GO:0009044	skos:altLabel	"xylobiase"
GO:0009044	skos:altLabel	"exo-1,4-beta-xylosidase"
GO:0009044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylobiase activity
REACT:R-GGA-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)
RHEA:70269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(out) + Na(+)(out) => hydrogencarbonate(in) + Na(+)(in)
REACT:R-DDI-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Dictyostelium discoideum)
REACT:R-HSA-5389845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUFM:GTP binds aminoacyl-tRNA (Homo sapiens)
REACT:R-DDI-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Dictyostelium discoideum)
REACT:R-MMU-174916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of N-glucuronides (Mus musculus)
REACT:R-DRE-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Danio rerio)
REACT:R-DME-1307963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Drosophila melanogaster)
REACT:R-HSA-141409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mad1 binds kinetochore (Homo sapiens)
REACT:R-HSA-9725345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM-ALK-dependent JUNB translation (Homo sapiens)
REACT:R-BTA-83791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Bos taurus)
RHEA:44625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH
RHEA:19424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxypropyl-coenzyme M <=> (R)-1,2-epoxypropane + coenzyme M
GO:0050169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-tryptophan 2,3-dioxygenase activity
GO:0050169	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyltryptophan 2,3-dioxygenase activity
GO:0050169	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrrolooxygenase activity
GO:0050169	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan pyrrolooxygenase activity
GO:0050169	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
REACT:R-DRE-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Danio rerio)
REACT:R-XTR-8848596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds PXN (Xenopus tropicalis)
REACT:R-HSA-4420140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Homo sapiens)
REACT:R-DRE-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Danio rerio)
GO:0089719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHG domain binding
GO:0089719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHG protein domain binding
GO:0089719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reaper hid grim domain binding
GO:0089719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inhibitor of apoptosis binding domain binding
GO:0089719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iap binding domain binding
REACT:R-BTA-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)
REACT:R-DRE-177937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of EGFR by SRC kinase (Danio rerio)
REACT:R-HSA-5692770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)
RHEA:59046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP => dammarenediol-II + UDP-alpha-D-glucose
GO:0035516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate-dependent DNA demethylase
GO:0035516	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-ethyladenine demethylase activity
GO:0035516	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	N1-methyladenine demethylase activity
GO:0035516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidative DNA demethylase activity
GO:0035516	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	N3-methylcytosine demethylase activity
REACT:R-CEL-71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Caenorhabditis elegans)
REACT:R-MMU-5138432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 is phosphorylated by PKC (Mus musculus)
REACT:R-RNO-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:60255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + NADP(+) <=> acryloyl-CoA + CO2 + NADPH
RHEA:24478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + maleamate => H2O + maleimide
REACT:R-DME-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Drosophila melanogaster)
RHEA:72859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-c-tri-AMP + H2O = A[3'-5']pA[3'-5']pAp[3'] + H(+)
REACT:R-RNO-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
REACT:R-RNO-388811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-1 homodimer (Rattus norvegicus)
RHEA:70119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine
REACT:R-XTR-5683384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UIMC1 and FAM175A bind DNA DSBs (Xenopus tropicalis)
RHEA:59598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+) => H2O + kynuramine + O2
RHEA:24451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin + UDP-alpha-D-glucose <=> monoglucosyl-enterobactin + UDP
RHEA:20434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + xylitol => D-xylulose + H(+) + NADH
EC:3.4.22.39	skos:prefLabel	"adenain"
EC:3.4.22.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenain"
GO:0034257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-riboside(in) = beta-nicotinamide D-riboside(out)
GO:0034257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide riboside transmembrane transporter activity
REACT:R-CFA-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Canis familiaris)
RHEA:63809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + spermidine => AMP + diphosphate + H(+) + N(8)-citryl-spermidine
REACT:R-SSC-9638076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from small HA fragments (Sus scrofa)
REACT:R-DRE-5669240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLNA binds PAK1 (Danio rerio)
REACT:R-XTR-2168885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin binds Hemoglobin (Xenopus tropicalis)
REACT:R-RNO-2022065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPGs are secreted (Rattus norvegicus)
REACT:R-HSA-5693539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)
REACT:R-SSC-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)
REACT:R-BTA-158747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Bos taurus)
RHEA:49525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 => a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate
REACT:R-SCE-376357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp7 associated Lysosome to Plasma membrane transport (Saccharomyces cerevisiae)
REACT:R-CEL-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
RHEA:60893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O => a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)
RHEA:56125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-lycopene + dimethylallyl diphosphate + H2O => AH2 + diphosphate + nonaflavuxanthin
RHEA:54723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-HSA-6804762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 forms homotetramers (Homo sapiens)
REACT:R-BTA-3878123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of SAHF formation (Bos taurus)
RHEA:17320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H(+) + phytyl diphosphate <=> chlorophyll a + diphosphate
RHEA:57863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-6-hydroxyferuloyl-CoA <=> CoA + scopoletin
RHEA:71786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate(out) + H(+)(out) <=> 3-methyl-2-oxobutanoate(in) + H(+)(in)
EC:1.7.1.1	skos:prefLabel	"nitrate reductase (NADH)"
EC:1.7.1.1	skos:altLabel	"NADH:nitrate oxidoreductase"
EC:1.7.1.1	skos:altLabel	"assimilatory NADH:nitrate reductase"
EC:1.7.1.1	skos:altLabel	"NADH-nitrate reductase"
EC:1.7.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrate reductase (NADH)"
EC:1.7.1.1	skos:altLabel	"NADH-dependent nitrate reductase"
EC:1.7.1.1	skos:altLabel	"assimilatory nitrate reductase"
EC:1.7.1.1	skos:altLabel	"nitrate reductase (NADH2)"
REACT:R-RNO-5668735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX3 complex (Rattus norvegicus)
RHEA:22353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-lysine => cadaverine + CO2
REACT:R-BTA-9033499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Bos taurus)
REACT:R-XTR-8848005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 promotes PTK6 autophosphorylation (Xenopus tropicalis)
REACT:R-DME-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Drosophila melanogaster)
REACT:R-MMU-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Mus musculus)
RHEA:70851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)
REACT:R-RNO-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Rattus norvegicus)
RHEA:26062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine <=> methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)
RHEA:50568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]
RHEA:18849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] = a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:43364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose = beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP
RHEA:62625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutaredoxin]-dithiol + a hydroperoxide => [glutaredoxin]-disulfide + an alcohol + H2O
RHEA:64702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetophenone + H(+) + NADH => 1-phenylethanol + NAD(+)
RHEA:29112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + ubiquinone-8 => NADP(+) + ubiquinol-8
REACT:R-HSA-9020274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Homo sapiens)
REACT:R-BTA-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
RHEA:59920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H2O + NAD(+) = (2E)-octenoate + 2 H(+) + NADH
RHEA:69242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => glucoraphanin + H2O
REACT:R-BTA-193682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves the p75NTR transmembrane domain (Bos taurus)
RHEA:61842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brassicasterol 3-beta-D-glucoside + H(+) + UDP => brassicasterol + UDP-alpha-D-glucose
REACT:R-BTA-5607736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 oligomerizes (Bos taurus)
REACT:R-GGA-388863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Gallus gallus)
REACT:R-MMU-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)
REACT:R-DRE-2424246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind lecticans (Danio rerio)
REACT:R-MMU-5423647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2A13 oxidises AFM1 to AFM1E (Mus musculus)
REACT:R-GGA-5607023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IXa associates with cell membrane (Gallus gallus)
RHEA:47638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+) => H2O + L-arginine + NADP(+)
REACT:R-HSA-163751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Homo sapiens)
RHEA:35851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-CFA-114542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1,RAC2,RHOG activate PI3K (Canis familiaris)
REACT:R-XTR-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Xenopus tropicalis)
REACT:R-DDI-9026780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Dictyostelium discoideum)
REACT:R-BTA-6807866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the ERGIC (Bos taurus)
RHEA:40801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoate + CoA + H(+) => 2-methylpropanoyl-CoA + H2O
REACT:R-GGA-9674131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)
REACT:R-HSA-77613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR2 homodimer to dsRNA duplex (Homo sapiens)
REACT:R-CFA-73718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBF-1 Binds rDNA Promoter (Canis familiaris)
REACT:R-DRE-158766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Danio rerio)
REACT:R-CEL-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Caenorhabditis elegans)
REACT:R-BTA-937029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Bos taurus)
REACT:R-SCE-9014627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDS dimers:PXLP dehydrate L-Thr to 2AA (Saccharomyces cerevisiae)
REACT:R-DME-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Drosophila melanogaster)
RHEA:55746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n) => coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-390453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)
REACT:R-DME-8854044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)
REACT:R-RNO-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Rattus norvegicus)
RHEA:43063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> beta-D-glucose 1-phosphate + glycerol
RHEA:29748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate(in) => 3-phenylpropanoate(out)
REACT:R-HSA-9706330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS6 (Homo sapiens)
REACT:R-DME-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Drosophila melanogaster)
REACT:R-CFA-420233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VIP receptors bind VIP (Canis familiaris)
REACT:R-DDI-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Dictyostelium discoideum)
REACT:R-HSA-9029591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ABCG8 regulated by NR1H2 or NR1H3 (Homo sapiens)
RHEA:59714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraonate + H(+) => D-maltotetraono-1,5-lactone + H2O
REACT:R-BTA-8871260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD2 (Bos taurus)
REACT:R-MMU-418576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 1:Gq complex (Mus musculus)
REACT:R-HSA-83793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Homo sapiens)
RHEA:66424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + leukotriene B4(in) = ADP + H(+) + leukotriene B4(out) + phosphate
REACT:R-HSA-983703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)
REACT:R-CFA-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Canis familiaris)
EC:3.4.21.61	skos:altLabel	"proteinase yscF"
EC:3.4.21.61	skos:altLabel	"prohormone-processing endoprotease"
EC:3.4.21.61	skos:altLabel	"yeast KEX2 protease"
EC:3.4.21.61	skos:prefLabel	"kexin"
EC:3.4.21.61	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kexin"
EC:3.4.21.61	skos:altLabel	"paired-basic endopeptidase"
REACT:R-SSC-213407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from SLP-76 (Sus scrofa)
RHEA:17000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol <=> 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-DRE-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Danio rerio)
REACT:R-HSA-2168046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XII degradation by MMP12 (Homo sapiens)
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteinyl-tRNA(Ser) selenium transferase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-selenocysteinyl-tRNASel synthase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	selenophosphate:L-seryl-tRNASec selenium transferase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-selenocysteinyl-tRNASec synthase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-tRNA(Ser) selenium transferase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-tRNASec selenium transferase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenocysteine synthase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-selenocysteinyl-tRNA(Sel) synthase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenocysteinyl-tRNA(Ser) synthase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteinyl-tRNA(Sec)-selenium transferase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-selenocysteinyl-tRNA(Sec) synthase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteinyl-tRNASel-selenium transferase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteinyl-tRNASec-selenium transferase activity
GO:0004125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteinyl-tRNA(Sel)-selenium transferase activity
RHEA:48795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + Lc4Cer <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
REACT:R-DME-6808487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)
REACT:R-DME-209129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex (Drosophila melanogaster)
REACT:R-BTA-77345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Bos taurus)
REACT:R-CFA-9645428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 binds ADP-heptose (Canis familiaris)
GO:0034348	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-lambda receptor activity
GO:0034348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type III interferon receptor activity
RHEA:60508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine
RHEA:19544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + L-glutamyl 5-phosphate + NADPH
REACT:R-DME-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Drosophila melanogaster)
REACT:R-DME-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Drosophila melanogaster)
REACT:R-XTR-8850326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds self-lipid-based antigen via CD1 (Xenopus tropicalis)
REACT:R-HSA-2424481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)
REACT:R-DDI-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)
RHEA:42213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
RHEA:40160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose
RHEA:42576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O = 2-methylpropanoate + 2-oxopent-4-enoate + H(+)
REACT:R-DRE-9641109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Danio rerio)
REACT:R-BTA-5676917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Bos taurus)
GO:0047039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + scytalone = H(+) + NADPH + naphthalene-1,3,6,8-tetrol
GO:0047039	skos:prefLabel	"tetrahydroxynaphthalene reductase"
GO:0047039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T4HN reductase activity
GO:0047039	skos:altLabel	"T4HN reductase"
GO:0047039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	scytalone:NADP+ delta5-oxidoreductase activity
GO:0047039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrahydroxynaphthalene reductase"
GO:0047039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydroxynaphthalene reductase activity
REACT:R-DME-209130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length SPZ dimer is cleaved by EA/SPE serine protease (Drosophila melanogaster)
RHEA:66189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP(in) + ATP + H2O => 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate
RHEA:69904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(out) + 2 Na(+)(out) => cytidine(in) + 2 Na(+)(in)
RHEA:15351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + N-acetyl-L-glutamate => L-glutamate + N(2)-acetyl-L-ornithine
RHEA:59178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + O-phospho-L-serine => ADP + L-serine
RHEA:71628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) + succinate(out) => phosphate(out) + succinate(in)
REACT:R-HSA-1236958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of particulate antigens with dendritic cell receptors (Homo sapiens)
REACT:R-SSC-373745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK1 homophillic interaction (Sus scrofa)
REACT:R-DRE-170070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Danio rerio)
REACT:R-DRE-9611839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β3-agonists bind ADRB3 (Danio rerio)
REACT:R-HSA-9668398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
RHEA:72265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + oxalate(out) => chloride(out) + oxalate(in)
REACT:R-RNO-8867240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPCAM binds itself to form homotypic cell adhesion (Rattus norvegicus)
EC:3.4.21.89	skos:prefLabel	"signal peptidase I"
EC:3.4.21.89	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"signal peptidase I"
EC:3.4.21.89	skos:altLabel	"SPase I"
EC:3.4.21.89	skos:altLabel	"bacterial leader peptidase I"
EC:3.4.21.89	skos:altLabel	"phage-procoat-leader peptidase"
RHEA:26517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexan-1,2-dione + H2O <=> 6-oxohexanoate + H(+)
REACT:R-DME-83790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Drosophila melanogaster)
REACT:R-DRE-392187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated P2Y purinoceptor 12 binds G-protein Gi (Danio rerio)
REACT:R-RNO-392748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds to AP-2 Clathrin complex (Rattus norvegicus)
RHEA:47540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxolithocholate + H(+) + NADPH = NADP(+) + ursodeoxycholate
REACT:R-SSC-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Sus scrofa)
REACT:R-DME-2076419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Drosophila melanogaster)
GO:0102891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity
REACT:R-MMU-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Mus musculus)
REACT:R-MMU-2454118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cRAL binds to opsin to form 11c-retinyl:RHO (Mus musculus)
REACT:R-DDI-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Dictyostelium discoideum)
REACT:R-CEL-1855202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)
REACT:R-DME-168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNKs phosphorylate c-JUN (Drosophila melanogaster)
REACT:R-BTA-2046298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to a branch of keratan (Bos taurus)
REACT:R-XTR-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Xenopus tropicalis)
RHEA:20351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + toluene
RHEA:33132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate => 3-phenylpyruvate + tetrahydrotyrosine
REACT:R-HSA-5633051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFCAB7:IQCE binds EVC2:EVC (Homo sapiens)
GO:0008443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphofructokinase activity
GO:0102235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-penten-3-one reductase activity
GO:0050064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity
GO:0050064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin 7-O-glucoronosyltransferase activity
GO:0050064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity
GO:0050064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LGT
GO:0050064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity
GO:0050064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin 7-O-glucuronosyltransferase activity
REACT:R-CFA-2453863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRA6 transports atROL from extracellular region to cytosol (Canis familiaris)
REACT:R-MMU-6806974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET dimers autophosphorylate (Mus musculus)
REACT:R-BTA-449115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)
REACT:R-DRE-372693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BCAR1 by SRC-PTK2 complex (Danio rerio)
REACT:R-CFA-201640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Canis familiaris)
REACT:R-SSC-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Sus scrofa)
RHEA:30426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-delta-selinene + diphosphate
RHEA:54741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Drosophila melanogaster)
RHEA:48017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-5-nitrocatechol + NADH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite
REACT:R-CEL-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Caenorhabditis elegans)
REACT:R-DME-5665989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIAPH1 binds RHOA:GTP (Drosophila melanogaster)
RHEA:51290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
RHEA:68218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol
RHEA:65720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + butyl sulfate + O2 = butanal + CO2 + H(+) + succinate + sulfate
RHEA:41915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-[ACP] + H(+) + NADPH <=> hexadecanoyl-[ACP] + NADP(+)
REACT:R-MMU-5252079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Mus musculus)
REACT:R-RNO-429786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Rattus norvegicus)
REACT:R-CEL-445084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by SRC (Caenorhabditis elegans)
RHEA:25399	skos:prefLabel	"9,12-octadecadienoate 8-hydroperoxide 8S-isomerase"
RHEA:25399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate
RHEA:25399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"9,12-octadecadienoate 8-hydroperoxide 8S-isomerase"
RHEA:25399	skos:altLabel	"(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming)"
REACT:R-XTR-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Xenopus tropicalis)
RHEA:60174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate
REACT:R-DME-5654397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS2 (Drosophila melanogaster)
REACT:R-BTA-429714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Bos taurus)
RHEA:55689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)
REACT:R-MMU-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Mus musculus)
RHEA:21839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O
RHEA:16751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + phosphate => H2O + phosphonoacetate
RHEA:70087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol + o-quinone methide = hydroxyclavatol methyl ether
REACT:R-SSC-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Sus scrofa)
REACT:R-RNO-9008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylation (Rattus norvegicus)
RHEA:54104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:28936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => oxaloacetate + pyruvate
REACT:R-SSC-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Sus scrofa)
REACT:R-DRE-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Danio rerio)
RHEA:54192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
RHEA:32521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine => (2E)-geranyl diphosphate + S-adenosyl-L-methionine
REACT:R-SSC-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Sus scrofa)
REACT:R-CFA-187688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Canis familiaris)
RHEA:43331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:42566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(38/39) in tRNA => uridine(38/39) in tRNA
REACT:R-DME-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Drosophila melanogaster)
REACT:R-DRE-2160884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Danio rerio)
RHEA:45869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-HSA-8961688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the FBXO5 gene promoter (Homo sapiens)
REACT:R-MMU-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Mus musculus)
REACT:R-HSA-1504213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Homo sapiens)
REACT:R-XTR-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Xenopus tropicalis)
GO:0140853	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cholesterol transferase activity
GO:0140853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol-protein transferase activity
REACT:R-MMU-2730900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to pUb-TRAF6 (Mus musculus)
REACT:R-CFA-77614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR1) (Canis familiaris)
RHEA:60364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in)
REACT:R-MMU-2534378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hv1 Mediated H+ Permeability (Mus musculus)
REACT:R-MMU-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Mus musculus)
REACT:R-GGA-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Gallus gallus)
RHEA:65158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + preaustinoid A3 + succinate => 2-oxoglutarate + O2 + preaustinoid A2
RHEA:27652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + UMP => GTP + uridine
REACT:R-RNO-211191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF with alpha:beta importin (Rattus norvegicus)
GO:0008427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent protein kinase inhibitor activity
REACT:R-DRE-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Danio rerio)
REACT:R-DME-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Drosophila melanogaster)
REACT:R-GGA-5685605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF7 binds SLAMF7 (Gallus gallus)
REACT:R-CFA-3132737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate ETS1 and ETS2 (Canis familiaris)
RHEA:51710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-tagatose + NADH => D-altritol + NAD(+)
REACT:R-PFA-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Plasmodium falciparum)
REACT:R-BTA-4570553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO2,3 (Bos taurus)
RHEA:31343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosyl-3-phosphoglycerate phosphatase"
RHEA:31343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate
RHEA:31343	skos:prefLabel	"glucosyl-3-phosphoglycerate phosphatase"
GO:0047826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-2,6-diaminohexanoate 5,6-aminomutase activity
GO:0047826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity
GO:0047826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine 5,6-aminomutase activity
GO:0047826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alpha-lysine mutase activity
REACT:R-BTA-9011748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R binds JAK1 (Bos taurus)
RHEA:46880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP
RHEA:24769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + NAD(+) => chlorophyllide b + H(+) + NADH
REACT:R-BTA-1433423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP-RO interacts with p-c-Kit complex (Bos taurus)
GO:0051737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity
GO:0051737	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GTP-dependent polynucleotide 5'-hydroxyl-kinase activity
GO:0051737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent polydeoxyribonucleotide kinase activity
GO:0051737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent DNA 5'-hydroxyl-kinase activity
GO:0051737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0051737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent DNA kinase activity
REACT:R-HSA-3697008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP acetylates histone H2B, H3, H4 (Homo sapiens)
REACT:R-RNO-168412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP elicits a NOD2 response (Rattus norvegicus)
RHEA:64180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-tryptophan + H2O = a fatty acid + L-tryptophan
REACT:R-BTA-5218819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
REACT:R-BTA-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Bos taurus)
RHEA:39520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)
REACT:R-XTR-202344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ZAP-70 to phosphorylated ITAMs (Xenopus tropicalis)
REACT:R-PFA-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Plasmodium falciparum)
REACT:R-MMU-6784189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind LIFR (Mus musculus)
REACT:R-SSC-1604690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MMP9 intermediate form by MMPs (Sus scrofa)
RHEA:10825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NADP(+) => H(+) + NADPH + oxaloacetate
EC:3.2.1.116	skos:altLabel	"exo-maltotriohydrolase"
EC:3.2.1.116	skos:prefLabel	"glucan 1,4-alpha-maltotriohydrolase"
EC:3.2.1.116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan 1,4-alpha-maltotriohydrolase"
REACT:R-SSC-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Sus scrofa)
REACT:R-DDI-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Dictyostelium discoideum)
REACT:R-CEL-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)
RHEA:16498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-HSA-5687112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 is degraded by the 26S proteasome (Homo sapiens)
REACT:R-PFA-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Plasmodium falciparum)
RHEA:60088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADPH
REACT:R-HSA-182990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty sequesters CBL away from active EGFR (Homo sapiens)
RHEA:52535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + GTP <=> AMP + GDP + H(+)
GO:0050246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	questin oxygenase activity
GO:0050246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)
GO:0050246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	questin monooxygenase activity
REACT:R-RNO-444572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zinc is an agonist of GPR39 (Rattus norvegicus)
REACT:R-HSA-5632970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH6 variant:MSH2-defective DNA mismatch repair (Homo sapiens)
RHEA:13416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + thymidine <=> AMP + dTMP + H(+)
REACT:R-DRE-9693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds 5HT (Danio rerio)
REACT:R-PFA-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Plasmodium falciparum)
REACT:R-HSA-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Homo sapiens)
REACT:R-BTA-1250264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP binds reduced thioredoxin (Bos taurus)
RHEA:36498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + ATP <=> ADP + alpha-D-glucose 6-phosphate + H(+)
RHEA:48273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-XTR-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Xenopus tropicalis)
RHEA:28119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose => D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP
REACT:R-GGA-374214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CXCR4 and 7 bind CXCL12 ligand (Gallus gallus)
REACT:R-HSA-4549368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALG2 does not transfer a second Man to N-glycan precursor (Homo sapiens)
REACT:R-CEL-2064417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-1 (TJP1) (Caenorhabditis elegans)
REACT:R-SSC-2993898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRK1/VRK2 phosphorylate BANF1 (Sus scrofa)
RHEA:37817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2
REACT:R-DDI-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Dictyostelium discoideum)
RHEA:71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate(out) + H(+)(out) = 3-methyl-2-oxobutanoate(in) + H(+)(in)
RHEA:25699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-hexahomomethionine => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O
REACT:R-HSA-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Homo sapiens)
REACT:R-SSC-2993447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6x(PCCA:PCCB) (Sus scrofa)
RHEA:52281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate
RHEA:67138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoyl-CoA + ADP + phosphate => 3-hydroxypropanoate + ATP + CoA
REACT:R-SSC-202214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Lck-pY505 by CD45 (Sus scrofa)
REACT:R-CFA-8876366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL translocates from endosome lumen to lysosome lumen (Canis familiaris)
REACT:R-SCE-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Saccharomyces cerevisiae)
REACT:R-BTA-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Bos taurus)
RHEA:13816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene + H(+) + NADH + O2 <=> cis-1,2-dihydrobenzene-1,2-diol + NAD(+)
RHEA:38996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:30427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate
RHEA:30427	skos:prefLabel	"(+)-germacrene D synthase"
RHEA:30427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-germacrene D synthase"
REACT:R-CFA-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Canis familiaris)
REACT:R-CFA-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Canis familiaris)
GO:0052842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)
GO:0052842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol diphosphate pentakisphosphate diphosphatase activity
RHEA:59365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)
RHEA:49142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-5661086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane (Homo sapiens)
RHEA:66981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + H2O => 2-methylbutanoate + CoA + H(+)
GO:0140860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-2'-hydroxyisoflavanone reductase activity
GO:0140860	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vestitone reductase activity
REACT:R-MMU-5674496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate MAP2K1 (Mus musculus)
REACT:R-MMU-2426450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins:Nidogens binds collagen type IV networks (Mus musculus)
RHEA:62684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norrubrofusarin + S-adenosyl-L-methionine = H(+) + rubrofusarin + S-adenosyl-L-homocysteine
RHEA:20994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine => 16-hydroxytabersonine + S-adenosyl-L-methionine
REACT:R-DME-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Drosophila melanogaster)
REACT:R-MMU-380942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LKB1 forms a trimeric complex with STRAD and MO25 (Mus musculus)
RHEA:41828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O
REACT:R-DME-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Drosophila melanogaster)
GO:0120325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NuRD complex binding
RHEA:57110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:13837	skos:prefLabel	"phthalate 4,5-cis-dihydrodiol dehydrogenase"
RHEA:13837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phthalate 4,5-cis-dihydrodiol dehydrogenase"
RHEA:13837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH
REACT:R-MMU-389986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Mus musculus)
RHEA:35741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone => cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin]
REACT:R-SSC-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Sus scrofa)
RHEA:10747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) <=> 3,4-dihydroxybenzoate + CO2 + NADH
RHEA:41030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA
REACT:R-SSC-6786239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)
RHEA:11668	skos:prefLabel	"alpha-glucan, water dikinase"
RHEA:11668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate
RHEA:11668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-glucan, water dikinase"
RHEA:11668	skos:altLabel	"alpha-glucan,water dikinase"
RHEA:11668	skos:altLabel	"starch-related R1 protein"
RHEA:63588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D-glucuronide + UDP
RHEA:61472	skos:altLabel	"mammalian ceramide synthase 5"
RHEA:61472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CoA + H(+)
RHEA:61472	skos:prefLabel	"sphingoid base N-palmitoyltransferase"
RHEA:61472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingoid base N-palmitoyltransferase"
REACT:R-RNO-888589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GABA at the synapse (Rattus norvegicus)
REACT:R-MMU-9018572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates NOTCH3 (Mus musculus)
REACT:R-DDI-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Dictyostelium discoideum)
RHEA:15719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	doxorubicin + H2O + NADP(+) => daunorubicin + H(+) + NADPH + O2
RHEA:23821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose => GDP-4-dehydro-alpha-D-rhamnose + H2O
REACT:R-MMU-8854408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOBR dimer binds VLDLs (Mus musculus)
RHEA:59148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + pseudomonate C = AMP + diphosphate + pseudomonoyl-CoA C
RHEA:59148	skos:prefLabel	"marinolic acid--CoA ligase"
RHEA:59148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + marinolate C = AMP + diphosphate + marinoloyl-CoA C
RHEA:59148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"marinolic acid--CoA ligase"
REACT:R-MMU-5687094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 phosphorylate MAPKAPK5 (Mus musculus)
REACT:R-CEL-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Caenorhabditis elegans)
REACT:R-BTA-1655879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiosulfate can transfer its sulfur atom to glutathione (Bos taurus)
REACT:R-SSC-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Sus scrofa)
GO:0008735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]
GO:0008735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-carnitine dehydratase activity
GO:0008735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-carnitine CoA-transferase activity
GO:0008735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-carnitine hydro-lyase activity
RHEA:65077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
GO:0042924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMU binding
GO:0042924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuromedin U binding
RHEA:20471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + hypoxanthine => H2O + IMP
REACT:R-CFA-211186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DFF45 (224) by caspase-3 (Canis familiaris)
REACT:R-SSC-6811479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 recruits EP300 to TP53 (Sus scrofa)
RHEA:18772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfanyl-2,3-dioxopentyl phosphate <=> 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate
REACT:R-BTA-6785933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT8 transfers Gal from UDP-Gal to CERA (Bos taurus)
REACT:R-DME-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Drosophila melanogaster)
REACT:R-BTA-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Bos taurus)
REACT:R-XTR-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Xenopus tropicalis)
REACT:R-XTR-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Xenopus tropicalis)
REACT:R-GGA-216050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Gallus gallus)
REACT:R-RNO-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Rattus norvegicus)
REACT:R-GGA-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Gallus gallus)
REACT:R-MMU-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Mus musculus)
RHEA:22886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + glycine => glyoxylate + L-methionine
REACT:R-MMU-904864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Mus musculus)
RHEA:45344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside NORint (d18:1(4E)) + H(+) + UDP
REACT:R-CFA-8852317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GTSE1 (Canis familiaris)
REACT:R-RNO-9678737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR1:TYK2 binds TYK2 inhibitors (Rattus norvegicus)
RHEA:59852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)
RHEA:52732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)
RHEA:43438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrin III + 3 H2O2 => coproporphyrinogen III + 3 O2
REACT:R-CFA-9020256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Canis familiaris)
REACT:R-DDI-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Dictyostelium discoideum)
GO:0033913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan endo-1,2-beta-glucosidase activity
GO:0033913	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-1,2-glucanase activity
GO:0033913	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-(1->2)-beta-D-glucanase activity
GO:0033913	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-beta-D-glucan glucanohydrolase activity
GO:0033913	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,2-beta-glucanase activity
REACT:R-DRE-5675656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA:EDAR binds EDARADD (Danio rerio)
REACT:R-SSC-5625426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde IFT (Sus scrofa)
RHEA:30588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + dimethyl sulfoxide => 2-demethylmenaquinone-8 + dimethyl sulfide + H2O
REACT:R-HSA-5654705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-HSA-83788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to Type 2 promoter (Homo sapiens)
REACT:R-GGA-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Gallus gallus)
REACT:R-GGA-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Gallus gallus)
RHEA:41882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-[ACP] + NADP(+) => (2E)-dodecenoyl-[ACP] + H(+) + NADPH
REACT:R-SSC-5591086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA5 binds activated protein C (Sus scrofa)
REACT:R-CEL-1169398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host protein filamin B (Caenorhabditis elegans)
RHEA:67296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2
REACT:R-HSA-8937613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHBP binds CRH (Homo sapiens)
RHEA:42473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzo-p-dioxin + NADH + O2 => 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)
REACT:R-HSA-5627870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 does not transport I- from cytosol to extracellular region (Homo sapiens)
RHEA:28995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-threonine(in) = H(+)(in) + L-threonine(out)
REACT:R-BTA-5607742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Bos taurus)
REACT:R-HSA-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Homo sapiens)
RHEA:38825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine
REACT:R-XTR-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Xenopus tropicalis)
RHEA:36943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA
REACT:R-HSA-8855375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dissociates from CSK (Homo sapiens)
RHEA:30844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formylmaleamate => formate + H(+) + maleamate
REACT:R-PFA-8954468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Plasmodium falciparum)
REACT:R-PFA-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Plasmodium falciparum)
RHEA:22003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + NADP(+) <=> D-xylono-1,5-lactone + H(+) + NADPH
RHEA:13946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-mandelate => (R)-mandelate
REACT:R-BTA-975119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Bos taurus)
RHEA:50475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + H(+) + malonyl-CoA <=> (2-aminobenzoyl)acetyl-CoA + CO2 + CoA
REACT:R-RNO-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)
REACT:R-HSA-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Homo sapiens)
RHEA:72901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proatranorin I + S-adenosyl-L-homocysteine => 4-O-demethylbarbatate + S-adenosyl-L-methionine
REACT:R-GGA-9640168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Gallus gallus)
RHEA:28548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-fructose => alpha-D-glucose
RHEA:29727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethane-1-sulfonate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + sulfite
REACT:R-HSA-8853911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX stimulates TP53 gene expression (Homo sapiens)
REACT:R-GGA-5665999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 translocates from cytosol to the nucleus (Gallus gallus)
RHEA:11570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP
EC:3.4.24.62	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"magnolysin"
EC:3.4.24.62	skos:altLabel	"neurosecretory granule protease cleaving pro-ocytocin/neurophysin"
EC:3.4.24.62	skos:prefLabel	"magnolysin"
REACT:R-XTR-5661121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Xenopus tropicalis)
RHEA:60713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic alcohol + NAD(+) => (+)-artemisinic aldehyde + H(+) + NADH
REACT:R-BTA-3899291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of EP300 with SUMO1 (Bos taurus)
RHEA:64499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7,9,11-pentaoxododecanoyl-[ACP] <=> 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]
RHEA:54142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA precursor + S-adenosyl-L-methionine
REACT:R-SCE-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Saccharomyces cerevisiae)
REACT:R-SPO-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Schizosaccharomyces pombe)
RHEA:48600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP
RHEA:14341	skos:altLabel	"2-hydroxy-3-oxoadipate synthetase"
RHEA:14341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO2
RHEA:14341	skos:prefLabel	"2-hydroxy-3-oxoadipate synthase"
RHEA:14341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-3-oxoadipate synthase"
RHEA:14341	skos:altLabel	"2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating)"
RHEA:14341	skos:altLabel	"alpha-ketoglutaric-glyoxylic carboligase"
RHEA:14341	skos:altLabel	"oxoglutarate: glyoxylate carboligase"
RHEA:47132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH
GO:0102030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-L-rhamnose synthetase activity
REACT:R-DRE-111751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)
REACT:R-MMU-193719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Mus musculus)
RHEA:20465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP
RHEA:35113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-L-idonate + NADP(+)
RHEA:63858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxytetradecanoate => O2 + tetradecanoate
REACT:R-CFA-5690701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 binds p-CD22 (Canis familiaris)
GO:0051989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen dehydrogenase activity
GO:0051989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HemN
GO:0051989	skos:altLabel	"oxygen-independent coproporphyrinogen-III oxidase"
GO:0051989	skos:altLabel	"coproporphyrinogen III oxidase"
GO:0051989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coproporphyrinogen dehydrogenase"
GO:0051989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxygen-independent coproporphyrinogen-III oxidase activity
GO:0051989	skos:prefLabel	"coproporphyrinogen dehydrogenase"
GO:0051989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	radical SAM enzyme activity
GO:0051989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX
GO:0051989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)
GO:0051989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coproporphyrinogen III oxidase activity
REACT:R-BTA-1222376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide from oxygen (Bos taurus)
RHEA:71069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-phenylalanine(in) => L-arginine(in) + L-phenylalanine(out)
RHEA:38651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)
REACT:R-SSC-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Sus scrofa)
REACT:R-CFA-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Canis familiaris)
RHEA:22828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)
RHEA:22828	skos:altLabel	"phosphoribosyl-ATP pyrophosphatase"
RHEA:22828	skos:prefLabel	"phosphoribosyl-ATP diphosphatase"
RHEA:22828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosyl-ATP diphosphatase"
RHEA:22828	skos:altLabel	"phosphoribosyladenosine triphosphate pyrophosphatase"
REACT:R-CFA-143468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEOS oxidizes ethanol to acetaldehyde (Canis familiaris)
RHEA:41048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA
REACT:R-XTR-374669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds NRP1 (Xenopus tropicalis)
REACT:R-XTR-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Xenopus tropicalis)
REACT:R-RNO-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Rattus norvegicus)
REACT:R-MMU-9757574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDL (Mus musculus)
REACT:R-MMU-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Mus musculus)
REACT:R-MMU-1604722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP9 by proteases (Mus musculus)
RHEA:33168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol
RHEA:62375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)
REACT:R-CFA-8955844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBKS phosphorylates ribose to R5P (Canis familiaris)
REACT:R-MMU-3134804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING ubiquitination by TRIM32 or TRIM56 (Mus musculus)
RHEA:59679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraose + O2 <=> D-maltotetraono-1,5-lactone + H2O2
REACT:R-RNO-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Rattus norvegicus)
REACT:R-XTR-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Xenopus tropicalis)
RHEA:32438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocarvone + H(+) + NADPH + O2 <=> 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
REACT:R-CFA-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Canis familiaris)
GO:0034864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,4-trimethylpentanal dehydrogenase activity
RHEA:57746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + phylloquinone => [protein]-disulfide + phylloquinol
RHEA:62080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-sulfate + NADP(+) = 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH
REACT:R-MMU-8940998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36RN, IL1F10 bind IL1RL2 (Mus musculus)
GO:0018593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorophenoxyacetate monooxygenase activity
REACT:R-HSA-2993898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)
REACT:R-DDI-9750016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Dictyostelium discoideum)
REACT:R-SCE-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Saccharomyces cerevisiae)
RHEA:17012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-succinylbenzoate + ATP + CoA <=> 2-succinylbenzoyl-CoA + AMP + diphosphate
REACT:R-HSA-428518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glypican-1 (GPC1) binds SLIT2 (Homo sapiens)
EC:2.3.1.257	skos:prefLabel	"N-terminal L-serine N(alpha)-acetyltransferase NatD"
EC:2.3.1.257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-terminal L-serine N(alpha)-acetyltransferase NatD"
REACT:R-DRE-9609743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Danio rerio)
REACT:R-CFA-9029566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Canis familiaris)
RHEA:15426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX
REACT:R-HSA-193661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDM4 translocates to the nucleus (Homo sapiens)
REACT:R-DRE-193668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR and RHOA-GDI interact (Danio rerio)
REACT:R-HSA-9013985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (Homo sapiens)
GO:0008146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphotransferase activity
GO:0008146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfotransferase activity
RHEA:26154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil
RHEA:28208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dUMP + H(+) => 2'-deoxyuridine + ATP
RHEA:61846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + solasodine 3-beta-D-glucoside + UDP => solasodine + UDP-alpha-D-glucose
GO:0033892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endodeoxyribonuclease (pyrimidine dimer) activity
GO:0033892	skos:prefLabel	"deoxyribonuclease (pyrimidine dimer)"
GO:0033892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonuclease (pyrimidine dimer) activity
GO:0033892	skos:altLabel	"endodeoxyribonuclease (pyrimidine dimer)"
GO:0033892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bacteriophage T4 endodeoxyribonuclease V activity
GO:0033892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T4 endonuclease V activity
GO:0033892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyribonuclease (pyrimidine dimer)"
REACT:R-DRE-8952749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Danio rerio)
RHEA:11535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H2O + O2 <=> glyoxylate + H2O2 + NH4(+)
REACT:R-MMU-5607744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 binds BCL10 (Mus musculus)
REACT:R-XTR-5218824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)
RHEA:45011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(octadecanoyl)-sphinganine <=> octadecanoate + sphinganine
RHEA:57995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside C-K + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP
RHEA:62998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + NH4(+) => (8Z,11Z,14Z)-eicosatrienamide + H2O
REACT:R-MMU-9699578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 phosphorylates CDKN1B (Mus musculus)
RHEA:11248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O = (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)
REACT:R-DDI-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Dictyostelium discoideum)
RHEA:66782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate => 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O
REACT:R-HSA-9683467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CQ, HCQ are protonated to CQ2+, HCQ2+ (Homo sapiens)
REACT:R-DRE-6799466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 dimerizes (Danio rerio)
RHEA:18612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + N(2)-acetyl-L-ornithine <=> H(+) + N(2)-acetyl-L-citrulline + phosphate
REACT:R-CFA-8849350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Canis familiaris)
RHEA:14061	skos:prefLabel	"strombine dehydrogenase"
RHEA:14061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(carboxymethyl)-D-alanine + NAD(+) = glycine + H(+) + NADH + pyruvate
RHEA:14061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"strombine dehydrogenase"
RHEA:27873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)
REACT:R-SPO-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Schizosaccharomyces pombe)
REACT:R-DRE-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Danio rerio)
REACT:R-MMU-5607728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)
REACT:R-HSA-2176445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD2 (Homo sapiens)
REACT:R-BTA-196402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Bos taurus)
REACT:R-GGA-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Gallus gallus)
GO:0031559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidosqualene cyclase activity
GO:0031559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-oxidosqualene cyclase activity
RHEA:48631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotide in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-158722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Homo sapiens)
REACT:R-HSA-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Homo sapiens)
RHEA:30946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + octanoyl-CoA <=> (2E)-octenoyl-CoA + FADH2
REACT:R-SCE-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Saccharomyces cerevisiae)
RHEA:28363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + H2O => dGMP + diphosphate + H(+)
RHEA:66927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA <=> [(R)-3-hydroxyalkanoate](n+1) + CoA
REACT:R-DDI-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
REACT:R-PFA-9020271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Plasmodium falciparum)
REACT:R-DME-9604480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFkB complex translocates from the cytosol to the nucleus (Drosophila melanogaster)
RHEA:47940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine
REACT:R-BTA-429698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKD1,2,3 phosphorylates CERT1-2 (Bos taurus)
RHEA:56898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-AMP + diphosphate => a carboxylate + ATP + H(+)
RHEA:41858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydecanoyl-[ACP] + NADP(+) => 3-oxodecanoyl-[ACP] + H(+) + NADPH
REACT:R-BTA-5694442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH2,3 bind GRIA1 (Bos taurus)
REACT:R-CEL-6809320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Caenorhabditis elegans)
REACT:R-DME-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Drosophila melanogaster)
RHEA:14439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-2-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2
RHEA:26155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil <=> 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate
RHEA:71801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(out) + H(+)(in) => Ca(2+)(in) + H(+)(out)
REACT:R-SSC-5671707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Sus scrofa)
RHEA:56266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
REACT:R-XTR-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Xenopus tropicalis)
REACT:R-DME-8938217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SWI/SNF complex (Drosophila melanogaster)
GO:0015924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-oligosaccharide mannosidase activity
REACT:R-RNO-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Rattus norvegicus)
RHEA:29446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanine(in) <=> H(+)(out) + L-alanine(out)
REACT:R-MMU-448427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 binds Interleukin-27 receptor (Mus musculus)
RHEA:49300	skos:prefLabel	"protein-N(pi)-phosphohistidine--maltose phosphotransferase"
RHEA:49300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]
RHEA:49300	skos:altLabel	"maltose PTS permease"
RHEA:49300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--maltose phosphotransferase"
GO:0010179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAA-Ala conjugate hydrolase activity
REACT:R-MMU-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Mus musculus)
REACT:R-RNO-427527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC dimethylates histone H3 at lysine-9 (Rattus norvegicus)
EC:7.5.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Catalysing the translocation carbohydrates and their derivatives"
EC:7.5.-.-	skos:prefLabel	"Catalysing the translocation carbohydrates and their derivatives"
RHEA:44010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-methyl fatty acid + 2 H(+) + NADH => a 2-methyl-branched fatty aldehyde + H2O + NAD(+)
REACT:R-BTA-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Bos taurus)
REACT:R-HSA-1236965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Export of peptide loaded MHC class I complex to PM (Homo sapiens)
REACT:R-DRE-381545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the IGF:IGFBP5:ALS complex (Danio rerio)
RHEA:23358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[rhodopsin] => ATP + L-seryl-[rhodopsin]
REACT:R-BTA-1912357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH ubiquitinates DTX (Bos taurus)
REACT:R-HSA-8851954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GAB1 recruits PI3K to MET (Homo sapiens)
RHEA:52408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH
RHEA:52408	skos:prefLabel	"4-phospho-D-erythronate 3-dehydrogenase"
RHEA:52408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-phospho-D-erythronate 3-dehydrogenase"
RHEA:32810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate(in) <=> thiosulfate(out)
REACT:R-HSA-1482696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)
GO:0140260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial proton-transporting ATP synthase complex binding
RHEA:34334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-pyruvate + NADPH + O2 <=> (indol-3-yl)acetate + CO2 + H2O + NADP(+)
REACT:R-RNO-349426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MDM4 by CHEK2 (Rattus norvegicus)
RHEA:31032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl cis-(+)-abscisate + UDP
REACT:R-GGA-173720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7 translocates to the plasma membrane (Gallus gallus)
REACT:R-CEL-8951676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TEADs and YAP1 (Caenorhabditis elegans)
RHEA:66219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-C7-CoA + O2 <=> asc-DeltaC7-CoA + H2O2
REACT:R-CFA-5686315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Canis familiaris)
REACT:R-BTA-186826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to the active receptor (Bos taurus)
RHEA:43160	skos:prefLabel	"tRNA1(Val) (adenine(37)-N(6))-methyltransferase"
RHEA:43160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA1(Val) (adenine(37)-N(6))-methyltransferase"
RHEA:43160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine
RHEA:37485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine
RHEA:68735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]
RHEA:42969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(56) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-8848335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37 binds  IL18R1 (Bos taurus)
RHEA:61777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside D + UDP-alpha-D-glucose => H(+) + rebaudioside M + UDP
REACT:R-BTA-349593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with Fibronectin (Bos taurus)
REACT:R-SSC-428749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-proten Gq (Sus scrofa)
REACT:R-DRE-200410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Danio rerio)
RHEA:11750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-fluoro-L-threonine + acetaldehyde => fluoroacetaldehyde + L-threonine
RHEA:43920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:46826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2
REACT:R-RNO-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Rattus norvegicus)
RHEA:35739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] = 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone
RHEA:35739	skos:altLabel	"cholesterol C20-22 desmolase"
RHEA:35739	skos:altLabel	"cholesterol side-chain-cleaving enzyme"
RHEA:35739	skos:altLabel	"cytochrome P-450scc"
RHEA:35739	skos:prefLabel	"cholesterol monooxygenase (side-chain-cleaving)"
RHEA:35739	skos:altLabel	"cholesterol side-chain cleavage enzyme"
RHEA:35739	skos:altLabel	"cholesterol desmolase"
RHEA:35739	skos:altLabel	"steroid 20-22 desmolase"
RHEA:35739	skos:altLabel	"cholesterol 20-22-desmolase"
RHEA:35739	skos:altLabel	"steroid 20-22-lyase"
RHEA:35739	skos:altLabel	"cytochrome p450scc"
RHEA:35739	skos:altLabel	"CYP11A1"
RHEA:35739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholesterol monooxygenase (side-chain-cleaving)"
RHEA:37806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:19286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol => a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol
RHEA:17540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinamide + H2O <=> (R)-carnitine + NH4(+)
REACT:R-BTA-8853762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET dimerizes (Bos taurus)
RHEA:72537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + vanillate => H2O + NADP(+) + vanillin
REACT:R-DME-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Drosophila melanogaster)
REACT:R-GGA-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Gallus gallus)
RHEA:64547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine
REACT:R-MMU-176664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + PAPS => estrone 3-sulfate + PAP (Mus musculus)
RHEA:23122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dipeptide(in) + ADP + H(+) + phosphate => a dipeptide(out) + ATP + H2O
RHEA:59784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH
RHEA:65648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine = a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine
GO:0015662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ion transporter activity
GO:0015662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0015662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ion transmembrane transporter activity, phosphorylative mechanism
GO:0015662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPase activity
GO:0015662	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
GO:0015662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Homo sapiens)
REACT:R-SPO-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Schizosaccharomyces pombe)
RHEA:17761	skos:prefLabel	"aryl-alcohol dehydrogenase (NADP(+))"
RHEA:17761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic primary alcohol + NADP(+) = an aromatic aldehyde + H(+) + NADPH
RHEA:17761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aryl-alcohol dehydrogenase (NADP(+))"
RHEA:67828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP
RHEA:64134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine
REACT:R-CEL-211164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO1A (Caenorhabditis elegans)
RHEA:25965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-benzoin + NADP(+) => benzil + H(+) + NADPH
RHEA:14316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iodophenol + S-adenosyl-L-methionine <=> 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine
RHEA:47341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidinol phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
REACT:R-RNO-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Rattus norvegicus)
REACT:R-DRE-1295634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is serine phosphorylated in response to MAPK activation (Danio rerio)
REACT:R-XTR-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Xenopus tropicalis)
REACT:R-XTR-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Xenopus tropicalis)
GO:0140396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5'-hydroxyaverantin dehydrogenase"
GO:0140396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'R)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + 2 H(+) + NADH
GO:0140396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'S)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + H(+) + NADH
GO:0140396	skos:altLabel	"HAVN dehydrogenase"
GO:0140396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-hydroxyaverantin dehydrogenase activity
GO:0140396	skos:prefLabel	"5'-hydroxyaverantin dehydrogenase"
RHEA:61208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-nitro-cGMP + L-cysteinyl-[protein] = H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]
REACT:R-BTA-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Bos taurus)
RHEA:13503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate => ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein]
REACT:R-HSA-173725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C9 binds C5b:C6:C7:C8 (Homo sapiens)
RHEA:17174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathionylspermidine + H2O => glutathione + spermidine
REACT:R-HSA-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Homo sapiens)
REACT:R-BTA-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Bos taurus)
REACT:R-HSA-1912363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR200B/C microRNAs bind NOTCH1 mRNA (Homo sapiens)
REACT:R-BTA-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Bos taurus)
REACT:R-DME-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)
RHEA:30363	skos:prefLabel	"fumonisin B1 esterase"
RHEA:30363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumonisin B1 + 2 H2O = (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate
RHEA:30363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumonisin B1 esterase"
REACT:R-XTR-76426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-atom dealkylation of caffeine (Xenopus tropicalis)
REACT:R-DRE-1971487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHSY3 transfer GalNAc to chondroitin (Danio rerio)
RHEA:50074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + H2O + tauroursodeoxycholate(in)
REACT:R-HSA-5682769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI2 binds ADAM22,23 (Homo sapiens)
RHEA:15110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + NADP(+) => (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH
REACT:R-HSA-5693609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53 at S15 (Homo sapiens)
REACT:R-XTR-5625426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde IFT (Xenopus tropicalis)
RHEA:56201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP
RHEA:30204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GDP + 2 H(+)
REACT:R-BTA-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Bos taurus)
REACT:R-MMU-1963589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Mus musculus)
RHEA:18040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O <=> N-carbamoylputrescine + NH4(+)
RHEA:30751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA
RHEA:38067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-DDI-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Dictyostelium discoideum)
RHEA:35053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose(in) => N,N'-diacetylchitobiose(out)
REACT:R-HSA-8964599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Homo sapiens)
REACT:R-SSC-2065357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)
REACT:R-XTR-4341025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR3C1 (GR) with SUMO1 (Xenopus tropicalis)
REACT:R-BTA-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Bos taurus)
REACT:R-BTA-209891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine is oxidised to noradrenaline (Bos taurus)
REACT:R-HSA-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)
RHEA:51356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-glutamine = (9Z)-octadecenoate + L-glutamine
REACT:R-SSC-163010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Down Regulation of Emi1 through Phosphorylation of Emi1 (Sus scrofa)
REACT:R-XTR-3149539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Xenopus tropicalis)
REACT:R-MMU-5635861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH binds GLI1 (Mus musculus)
REACT:R-XTR-9726875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCNs:cAMP bind SNIs (Xenopus tropicalis)
REACT:R-XTR-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Xenopus tropicalis)
REACT:R-SSC-5654667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
RHEA:54968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl phosphate + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate
RHEA:43935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + NAD(+) <=> androst-5-ene-3,17-dione + H(+) + NADH
RHEA:38946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate
REACT:R-HSA-9769011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds GEM gene promoter (Homo sapiens)
RHEA:66381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycodeoxycholate(in) + H2O => ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-18:1-2-18:2-phosphatidylcholine desaturase activity
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate synthase activity
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-18:1-2-18:3-phosphatidylcholinedesaturase activity
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine desaturase activity
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-lipid omega-6 desaturase (cytochrome b5)
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-18:1-2-18:2-phosphatidylcholine synthase activity
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oleate desaturase activity
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-16:0-2-18:1-phosphatidylcholine desaturase activity
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oleoyl-CoA desaturase activity
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-18:2-2-18:1-phosphatidylcholine desaturase activity (SN2-18:2 forming)
GO:0050184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oleoylphosphatidylcholine desaturase activity
RHEA:12748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,4-lactone + H2O <=> a 4-hydroxyacid + H(+)
RHEA:48119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-XTR-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Xenopus tropicalis)
RHEA:63020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+)
REACT:R-CEL-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)
GO:0043175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase core enzyme binding
REACT:R-SSC-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Sus scrofa)
REACT:R-CFA-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Canis familiaris)
REACT:R-HSA-3341296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX7,8 catalyze peroxidation of P4HB (PDI) (Homo sapiens)
REACT:R-BTA-452091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IL2RB Y338 enables SHC recruitment (Bos taurus)
REACT:R-RNO-8944240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type III (Rattus norvegicus)
REACT:R-SSC-373074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR9  binds CCL25 ligand (Sus scrofa)
RHEA:60661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-benzoquinone + H(+) + NADH => hydroquinone + NAD(+)
REACT:R-XTR-8871193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Xenopus tropicalis)
REACT:R-HSA-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Homo sapiens)
REACT:R-DRE-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Danio rerio)
RHEA:39982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+-)-pavine + S-adenosyl-L-methionine <=> H(+) + N-methylpavine + S-adenosyl-L-homocysteine
RHEA:61528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"omega-hydroxyceramide transacylase"
RHEA:61528	skos:prefLabel	"omega-hydroxyceramide transacylase"
RHEA:61528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine = a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine
RHEA:61528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base = a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base
GO:0052833	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	myo-inositol-1(or 4)-phosphate phosphohydrolase activity
GO:0052833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol monophosphate 4-phosphatase activity
GO:0052833	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol-1(or 4)-monophosphatase activity
GO:0052833	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	myo-inositol-1(or 4)-monophosphatase activity
RHEA:72955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + nicotinate(out) = 2 Na(+)(in) + nicotinate(in)
GO:0016231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-N-acetylglucosaminidase activity
REACT:R-HSA-9650447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 variant is not secreted (Homo sapiens)
REACT:R-DRE-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Danio rerio)
REACT:R-SSC-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)
REACT:R-CFA-444126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Canis familiaris)
REACT:R-DRE-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Danio rerio)
REACT:R-DRE-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Danio rerio)
REACT:R-DRE-5696049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
REACT:R-XTR-156526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Xenopus tropicalis)
REACT:R-XTR-1013013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of GABA B receptor with G protein beta-gamma subunits (Xenopus tropicalis)
RHEA:48323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 + GDP-beta-L-fucose <=> ganglioside Fuc-GA1 + GDP + H(+)
REACT:R-CFA-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Canis familiaris)
RHEA:33727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine = a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)
REACT:R-HSA-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Homo sapiens)
REACT:R-MMU-6787540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUK phosphorylates beta-Fuc to Fuc1P (Mus musculus)
REACT:R-BTA-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Bos taurus)
REACT:R-MMU-5654571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS3 (Mus musculus)
REACT:R-SPO-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Schizosaccharomyces pombe)
REACT:R-CFA-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Canis familiaris)
RHEA:20296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH
RHEA:10132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzoate--CoA ligase"
RHEA:10132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate
RHEA:10132	skos:prefLabel	"benzoate--CoA ligase"
REACT:R-CFA-9724685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds omalizumab (Canis familiaris)
RHEA:51481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-5423664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 hydroxylates AFB1 to AFQ1 (Rattus norvegicus)
RHEA:51945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine => 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine
REACT:R-CEL-2731078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 2, (4) bind TGFB1 (Caenorhabditis elegans)
REACT:R-CFA-416929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PGF2a (Canis familiaris)
REACT:R-HSA-9608039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the PLIN1 gene (Homo sapiens)
REACT:R-MMU-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Mus musculus)
REACT:R-HSA-9624017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SHC1 binds integrin alpha5beta1:fibronectin (Homo sapiens)
RHEA:53612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + D-ribulose 5-phosphate + H(+) = CDP-D-ribulose + diphosphate
REACT:R-DME-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Drosophila melanogaster)
RHEA:22503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H(+) + malonyl-CoA <=> (E)-feruloylacetyl-CoA + CO2 + CoA
REACT:R-HSA-9035514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALG9 does not add the last mannose to the N-glycan precursor (Homo sapiens)
REACT:R-HSA-5649724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)
RHEA:42848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-demethyltetracenomycin C L-rhamnosyltransferase"
RHEA:42848	skos:prefLabel	"8-demethyltetracenomycin C L-rhamnosyltransferase"
RHEA:42848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyltetracenomycin C + dTDP-beta-L-rhamnose = 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)
RHEA:47751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H(+) + n Na(+)(in) + NADH <=> a ubiquinol + n Na(+)(out) + NAD(+)
RHEA:50493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]
REACT:R-CEL-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Caenorhabditis elegans)
REACT:R-DRE-5602080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Danio rerio)
REACT:R-GGA-9677917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA inhibitors bind MAOA:FAD (Gallus gallus)
REACT:R-MMU-1067676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST-2 (Mus musculus)
REACT:R-MMU-8987179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Mus musculus)
RHEA:61689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-threonine => AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]
RHEA:21232	skos:altLabel	"histidase"
RHEA:21232	skos:altLabel	"histidine alpha-deaminase"
RHEA:21232	skos:altLabel	"histidinase"
RHEA:21232	skos:prefLabel	"histidine ammonia-lyase"
RHEA:21232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histidine ammonia-lyase"
RHEA:21232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine = NH4(+) + trans-urocanate
REACT:R-DME-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Drosophila melanogaster)
REACT:R-XTR-1482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by HADH (IM) (Xenopus tropicalis)
GO:0015366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-malic acid:proton symporter activity
GO:0015366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate permease
GO:0015366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-malic acid permease
GO:0015366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate:hydrogen symporter activity
GO:0015366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate:proton symporter activity
REACT:R-SSC-5687121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPKAPK5 phosphorylates HSPB1 (Sus scrofa)
REACT:R-BTA-2161775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12 oxidises LTA4 to LXA4/B4 (Bos taurus)
REACT:R-DRE-2404193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1R phosphorylates SHC1 (Danio rerio)
REACT:R-RNO-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:55782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate
REACT:R-XTR-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)
REACT:R-CFA-418170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB1 binds MAPKs, SRC-1 (Canis familiaris)
GO:0004663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rab-protein geranylgeranyltransferase activity
GO:0004663	skos:altLabel	"RabGGTase"
GO:0004663	skos:altLabel	"GGTaseII"
GO:0004663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTase-II activity
GO:0004663	skos:altLabel	"type II protein geranyl-geranyltransferase"
GO:0004663	skos:altLabel	"Rab geranylgeranyltransferase"
GO:0004663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II protein geranyl-geranyltransferase activity
GO:0004663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein geranylgeranyltransferase type II activity
GO:0004663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein geranylgeranyltransferase type II"
GO:0004663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
GO:0004663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTaseII activity
GO:0004663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rab geranylgeranyltransferase activity
GO:0004663	skos:prefLabel	"protein geranylgeranyltransferase type II"
GO:0004663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RabGGTase activity
REACT:R-DME-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Drosophila melanogaster)
RHEA:47900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate
GO:0033873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	petromyzonol sulfotransferase activity
GO:0033873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PZ-SULT
GO:0033873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity
REACT:R-MMU-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Mus musculus)
RHEA:48932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1b = CMP + ganglioside GQ1b + H(+)
REACT:R-XTR-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Xenopus tropicalis)
REACT:R-SPO-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Schizosaccharomyces pombe)
RHEA:44195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexadecanoate + ATP + CoA <=> 2-methylhexadecanoyl-CoA + AMP + diphosphate
REACT:R-HSA-5621571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD209 binds ICAM2 (Homo sapiens)
GO:0008792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine decarboxylase activity
GO:0008792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine carboxy-lyase activity
GO:0008792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine carboxy-lyase (agmatine-forming)
GO:0008792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SpeA
REACT:R-HSA-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)
RHEA:62540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain = dihydroouabain + 2 Fe(III)-[cytochrome c]
REACT:R-DRE-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)
REACT:R-HSA-8854290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds NS5A (Homo sapiens)
REACT:R-SSC-9706340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y-GRB10 binds PIK3R1 (Sus scrofa)
RHEA:43705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + tetradecanoate => diphosphate + tetradecanoyl-AMP
REACT:R-DME-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Drosophila melanogaster)
REACT:R-BTA-5685607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sialic acid binds SIGLEC (Bos taurus)
REACT:R-RNO-8948832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 polyubiquitinates PARylated PTEN (Rattus norvegicus)
REACT:R-DRE-9011984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A is recruited to MYC and BCL2 genes (Danio rerio)
GO:0051699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline oxidase activity
RHEA:20089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leucine N-acetyltransferase"
RHEA:20089	skos:prefLabel	"leucine N-acetyltransferase"
RHEA:20089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-leucine = CoA + H(+) + N-acetyl-L-leucine
REACT:R-DRE-418172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB2 (Danio rerio)
REACT:R-CFA-2022061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan sulfate can be further sulfated on position 2 of iduronate (Canis familiaris)
REACT:R-RNO-202534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of NEMO by TRAF6 (Rattus norvegicus)
RHEA:69772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty aldehyde + H2O + NAD(+) => a short-chain fatty acid + 2 H(+) + NADH
GO:0019215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intermediate filament binding
RHEA:66496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
REACT:R-MMU-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
RHEA:63705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolate + UDP-alpha-D-glucuronate => H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP
REACT:R-RNO-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Rattus norvegicus)
REACT:R-RNO-2507854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Rattus norvegicus)
REACT:R-SSC-5654620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
REACT:R-RNO-189398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)
REACT:R-DDI-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Dictyostelium discoideum)
REACT:R-BTA-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Bos taurus)
RHEA:55456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol
RHEA:55456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:55456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sugiol synthase"
RHEA:55456	skos:altLabel	"CYP76AH3"
RHEA:55456	skos:prefLabel	"sugiol synthase"
RHEA:18315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + hydrogen cyanide => (R)-mandelonitrile
REACT:R-RNO-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Rattus norvegicus)
REACT:R-RNO-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Rattus norvegicus)
REACT:R-CFA-5628905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Canis familiaris)
GO:0015929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexosaminidase activity
RHEA:70193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-NADP(+) + ADP + H(+) => ATP + NAD(+)
REACT:R-DRE-8982165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Danio rerio)
REACT:R-CEL-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
RHEA:27475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-beta-D-manno-heptose 7-phosphate
RHEA:12322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydrovomilenine + 2 H(+) + NADPH => 17-O-acetylnorajmaline + NADP(+)
REACT:R-CFA-209536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkB is ubiquitinated and degraded (Canis familiaris)
RHEA:26467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-demethylmenaquinone + S-adenosyl-L-methionine => a menaquinone + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Bos taurus)
REACT:R-BTA-158744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Bos taurus)
RHEA:69858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in mRNA + NADP(+) <=> a uridine in mRNA + H(+) + NADPH
RHEA:39441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA
RHEA:56974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-methylmalonate semialdehyde + H(+) + NADH => (R)-3-hydroxy-2-methylpropanoate + NAD(+)
REACT:R-XTR-5690046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT2 hydrolyses PALMCoA to PALM (Xenopus tropicalis)
REACT:R-DRE-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Danio rerio)
REACT:R-GGA-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Gallus gallus)
REACT:R-CFA-2424485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-PLCG1 (Canis familiaris)
RHEA:24242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + AH2 => A + AMP + 2 H(+) + sulfite
REACT:R-BTA-1234173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)
RHEA:59020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)
REACT:R-MMU-9620456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sGC stimulators bind sGC:NO (Mus musculus)
REACT:R-RNO-210274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP beta binds TYROBP (Rattus norvegicus)
REACT:R-MMU-192061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP46A1 24-hydroxylates CHOL (Mus musculus)
RHEA:54568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in rRNA = a pseudouridine in rRNA
REACT:R-CEL-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Caenorhabditis elegans)
RHEA:66118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + 2-oxoglutaramate => 2-oxobutanoate + L-glutamine
RHEA:51126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine in snRNA => uridine in snRNA
RHEA:57695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]
RHEA:28860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ag(+)(in) + H(+)(in) => Ag(+)(out) + H(+)(out)
GO:0102697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-zeatin-O-glucoside UDP glycosyltransferase activity
RHEA:23151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + propanoate <=> ADP + propanoyl phosphate
REACT:R-GGA-5610725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TULP3 is required for GPR161 localization in the cilium (Gallus gallus)
RHEA:45607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)
REACT:R-SSC-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Sus scrofa)
RHEA:72532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + methyl beta-D-galactoside(out) => ADP + H(+) + methyl beta-D-galactoside(in) + phosphate
REACT:R-CEL-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)
RHEA:66340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate
REACT:R-MMU-5668714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX1 complex (Mus musculus)
REACT:R-DRE-2161775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12 oxidises LTA4 to LXA4/B4 (Danio rerio)
REACT:R-GGA-2197646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1 (SR-BI, CLA-1) binds ligands (Gallus gallus)
GO:0018507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity
GO:0018507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol
GO:0018507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity
GO:0018507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase"
GO:0018507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity
GO:0018507	skos:prefLabel	"cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase"
REACT:R-MMU-5654169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 (Mus musculus)
RHEA:34427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-lariciresinol + NADP(+) = (-)-pinoresinol + H(+) + NADPH
RHEA:34427	skos:altLabel	"pinoresinol/lariciresinol reductase"
RHEA:34427	skos:altLabel	"pinoresinol-lariciresinol reductases"
RHEA:34427	skos:prefLabel	"(-)-pinoresinol reductase"
RHEA:34427	skos:altLabel	"(-)-pinoresinol-(-)-lariciresinol reductase"
RHEA:34427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-pinoresinol reductase"
RHEA:31845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxepin-2(3H)-ylideneacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
REACT:R-SSC-8871227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA4 (Sus scrofa)
RHEA:11972	skos:prefLabel	"bacterial non-heme ferritin"
RHEA:11972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacterial non-heme ferritin"
RHEA:11972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide
REACT:R-BTA-8871265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD4 (Bos taurus)
REACT:R-CFA-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)
RHEA:70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) => L-methionine(out)
RHEA:47582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT2 (d18:1(4E)) + H(+) + UDP => ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine
RHEA:46845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-174690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Homo sapiens)
REACT:R-MMU-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Mus musculus)
RHEA:10986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + pyruvate => (S)-lactate + oxaloacetate
REACT:R-RNO-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Rattus norvegicus)
RHEA:11675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate
GO:0004505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalaninase activity
GO:0004505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine hydroxylase activity
GO:0004505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
GO:0004505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAH activity
GO:0004505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine 4-hydroxylase activity
GO:0004505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine 4-monooxygenase activity
REACT:R-MMU-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Mus musculus)
REACT:R-MMU-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Mus musculus)
RHEA:60923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 <=> a cytidine in mRNA + CO2 + formaldehyde + succinate
RHEA:22698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + testololactone => AH2 + androst-4-ene-3,17-dione + O2
REACT:R-RNO-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Rattus norvegicus)
REACT:R-CFA-5684008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBN binds KPNA2 (Canis familiaris)
RHEA:67681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + H2O => a long-chain fatty acid + CoA + H(+)
REACT:R-RNO-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Rattus norvegicus)
REACT:R-HSA-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Homo sapiens)
RHEA:11486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out) => a quinol + 2 Fe(III)-[cytochrome c](out)
REACT:R-XTR-976801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I complex formation (Xenopus tropicalis)
REACT:R-HSA-2067713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP369 inhibits activation of amplified FGFR2 signaling (Homo sapiens)
REACT:R-MMU-158941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Mus musculus)
REACT:R-SSC-176700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Sus scrofa)
RHEA:21066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + glutathione disulfide => [protein]-disulfide + 2 glutathione
RHEA:21538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-glutaconyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA
GO:0043047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomeric ssDNA binding
GO:0043047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded telomeric DNA binding
RHEA:50504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]
RHEA:36250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-anol <=> H(+) + S-adenosyl-L-homocysteine + trans-anethole
RHEA:21140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + inosine = ADP + H(+) + IMP
REACT:R-DRE-170044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Danio rerio)
REACT:R-HSA-622390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRPC channels by Netrin-1 (Homo sapiens)
RHEA:46697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine => an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-204813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb14 (Bos taurus)
REACT:R-DRE-193679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-secretase cleaves the p75NTR extracellular domain (Danio rerio)
REACT:R-CFA-9705713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 dehydrogenates TEST to DHTEST (Canis familiaris)
REACT:R-MMU-2161613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Mus musculus)
RHEA:59632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylobiose + O2 = D-xylobiono-1,5-lactone + H2O2
RHEA:45526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] => phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]
RHEA:49381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:70294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-aminophenyl)-3-oxopropanal <=> H2O + quinolin-4-ol
RHEA:23523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + propanoate <=> acetate + propanoyl-CoA
REACT:R-CEL-5661117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Caenorhabditis elegans)
REACT:R-HSA-9036052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective NAGLU does not hydrolyse heparan chain(2) (Homo sapiens)
REACT:R-HSA-1791118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ASNS (Asparagine Synthetase) (Homo sapiens)
REACT:R-BTA-6799409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates TP53 (Bos taurus)
REACT:R-SSC-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Sus scrofa)
REACT:R-BTA-2160884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Bos taurus)
REACT:R-HSA-380227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)
REACT:R-DME-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Drosophila melanogaster)
RHEA:70243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-xylose = a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP
REACT:R-HSA-5336182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37 binds prosaptide (Homo sapiens)
REACT:R-DME-9749647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES2 hydrolyzes ASA- (Drosophila melanogaster)
RHEA:62390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n-2) + sophorose => [(1->2)-beta-D-glucosyl](n) + H2O
RHEA:55230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:48220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:66394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + prostaglandin E1(out) => ATP + H2O + prostaglandin E1(in)
REACT:R-CFA-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Canis familiaris)
GO:0102984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfoacetaldehyde dehydrogenase activity
RHEA:69287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 17beta-hydroxy steroid + NADP(+) <=> a 17-oxo steroid + H(+) + NADPH
RHEA:44490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine
REACT:R-DME-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Drosophila melanogaster)
REACT:R-GGA-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Gallus gallus)
REACT:R-MMU-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Mus musculus)
REACT:R-SPO-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Schizosaccharomyces pombe)
RHEA:37266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-aspartate(out) <=> ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate
RHEA:53747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-tRNA(Ala) + H2O <=> glycine + H(+) + tRNA(Ala)
RHEA:58151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl acetate + H2O <=> acetate + ethanol + H(+)
RHEA:39593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA
RHEA:27337	skos:prefLabel	"steroid 15beta-monooxygenase"
RHEA:27337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steroid 15beta-monooxygenase"
RHEA:27337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] = 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]
RHEA:27337	skos:altLabel	"CYP106A2"
RHEA:27337	skos:altLabel	"steroid 15beta-hydroxylase"
EC:3.4.11.7	skos:prefLabel	"glutamyl aminopeptidase"
EC:3.4.11.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamyl aminopeptidase"
EC:3.4.11.7	skos:altLabel	"aminopeptidase A"
EC:3.4.11.7	skos:altLabel	"angiotensinase A"
EC:3.4.11.7	skos:altLabel	"aspartate aminopeptidase"
EC:3.4.11.7	skos:altLabel	"glutamyl peptidase"
EC:3.4.11.7	skos:altLabel	"membrane aminopeptidase II"
RHEA:34297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose
RHEA:22493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formimidoyl-L-glutamate => formamide + L-glutamate
RHEA:12624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate <=> CO2 + L-alanine
REACT:R-CFA-9753285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)
REACT:R-RNO-5661290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Rattus norvegicus)
RHEA:32162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + epoxyqueuosine(34) in tRNA <=> A + H2O + queuosine(34) in tRNA
REACT:R-CEL-3165230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC52A1,2,3 transport RIB from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-BTA-5685366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y-SHC (Bos taurus)
RHEA:11150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2
REACT:R-BTA-5665751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP:FMNL2 binds Profilin:G-actin (Bos taurus)
REACT:R-DRE-429714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Danio rerio)
RHEA:59941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyloctadecanoyl-CoA + H2O => 2-methyloctadecanoate + CoA + H(+)
REACT:R-CFA-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Canis familiaris)
REACT:R-XTR-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Xenopus tropicalis)
RHEA:31619	skos:altLabel	"TDP-3-dehydro-6-deoxy-D-galactose 3-aminotransferase"
RHEA:31619	skos:altLabel	"dTDP-6-deoxy-D-xylohex-3-uloseaminase"
RHEA:31619	skos:altLabel	"TDP-3-keto-6-deoxy-D-galactose-3-aminotransferase"
RHEA:31619	skos:prefLabel	"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase"
RHEA:31619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate
RHEA:31619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase"
RHEA:31619	skos:altLabel	"TDP-3-keto-6-deoxy-D-galactose 3-aminotransferase"
RHEA:22742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-hexose 6-phosphate + H(+) => ATP + D-hexose
REACT:R-RNO-9759549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Rattus norvegicus)
RHEA:33754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
RHEA:58774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH
REACT:R-DRE-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
RHEA:56261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose => 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP
RHEA:12938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
REACT:R-XTR-1604731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP3 (Xenopus tropicalis)
REACT:R-SSC-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Sus scrofa)
REACT:R-CFA-140872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Canis familiaris)
REACT:R-CEL-9687828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-GlcNAcylation of RIPK3 (TLR4 signaling) (Caenorhabditis elegans)
RHEA:54948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] = (2E,5Z)-dodecadienoyl-[ACP] + H2O
RHEA:15338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phenylglyoxylyl-CoA => CoA + H(+) + phenylglyoxylate
REACT:R-HSA-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Homo sapiens)
REACT:R-DRE-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Danio rerio)
RHEA:65752	skos:prefLabel	"L-glutamate 3(R)-hydroxylase"
RHEA:65752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glutamate 3(R)-hydroxylase"
RHEA:65752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-glutamate + O2 = (3R)-3-hydroxy-L-glutamate + CO2 + succinate
REACT:R-SSC-9640237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Sus scrofa)
RHEA:11939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + trans-resveratrol
REACT:R-BTA-352029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Bos taurus)
REACT:R-SSC-5654669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Sus scrofa)
RHEA:28939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + xanthosine(in) = H(+)(out) + xanthosine(out)
REACT:R-CEL-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Caenorhabditis elegans)
REACT:R-BTA-5691154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HFE binds TFRC dimer (Bos taurus)
RHEA:38094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocotrienol + S-adenosyl-L-methionine <=> beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Mus musculus)
RHEA:17970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
RHEA:62833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate
REACT:R-MMU-8849906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM1 binds NMDA receptor (Mus musculus)
RHEA:71616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + sulfate(out) => (S)-malate(out) + sulfate(in)
RHEA:54194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => L-lysyl-[protein] + 3 S-adenosyl-L-methionine
REACT:R-SPO-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Schizosaccharomyces pombe)
RHEA:68744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine
RHEA:29304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + succinate(in) => 2 H(+)(out) + succinate(out)
REACT:R-MMU-9677917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA inhibitors bind MAOA:FAD (Mus musculus)
RHEA:16398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-glucopyranose 1-phosphate => D-glucose + D-glucose 1,6-bisphosphate
RHEA:34115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxynorspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine
REACT:R-GGA-351849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Etk (Gallus gallus)
REACT:R-XTR-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Xenopus tropicalis)
REACT:R-BTA-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Bos taurus)
GO:0050499	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0050499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
GO:0050499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor
RHEA:72740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)
RHEA:67479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-glutamate <=> diphosphate + prekainate
RHEA:57550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase]
EC:1.1.1.1	skos:prefLabel	"alcohol dehydrogenase"
EC:1.1.1.1	skos:altLabel	"aldehyde reductase"
EC:1.1.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol dehydrogenase"
REACT:R-XTR-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Xenopus tropicalis)
REACT:R-CFA-162836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Canis familiaris)
REACT:R-BTA-5654569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS2 (Bos taurus)
REACT:R-DRE-5627071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Danio rerio)
REACT:R-CFA-190245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1b binds to FGF (Canis familiaris)
REACT:R-HSA-211988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
RHEA:11509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartyl-[protein] + O2 => 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate
RHEA:50299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:64450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine
RHEA:71450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(in) + Na(+)(in) <=> D-alanine(out) + Na(+)(out)
RHEA:12840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + choline <=> ADP + H(+) + phosphocholine
RHEA:17281	skos:altLabel	"N-acetyldiaminobutyrate dehydratase"
RHEA:17281	skos:prefLabel	"ectoine synthase"
RHEA:17281	skos:altLabel	"N-acetyldiaminobutanoate dehydratase"
RHEA:17281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine
RHEA:17281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ectoine synthase"
RHEA:17281	skos:altLabel	"L-ectoine synthase"
GO:0047525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxydaidzein reductase activity
GO:0047525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:2'-hydroxydaidzein oxidoreductase activity
GO:0047525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity
GO:0047525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HDR activity
GO:0047525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity
GO:0047525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity
RHEA:52450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate
RHEA:62104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-BTA-9674131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 binds ATM dimer:Ub-p-PEX5 (Bos taurus)
GO:0033200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphoinositol-pentakisphosphate 5-kinase activity
GO:0033200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol heptakisphosphate 5-kinase activity
GO:0033200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP7 5-kinase activity
REACT:R-CFA-193369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Canis familiaris)
RHEA:42373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-methoxytabersonine + H2O => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine
RHEA:47197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-SSC-9755304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUL1 ubiquitinates UBXN7 (Sus scrofa)
RHEA:52104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)
REACT:R-CEL-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Caenorhabditis elegans)
REACT:R-RNO-74711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRS (Rattus norvegicus)
RHEA:55690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O
REACT:R-CFA-451377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IQGAP1 with nephrin (Canis familiaris)
REACT:R-XTR-159729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)
RHEA:21748	skos:prefLabel	"methylglyoxal reductase (NADPH)"
RHEA:21748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + NADP(+) = H(+) + methylglyoxal + NADPH
RHEA:21748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylglyoxal reductase (NADPH)"
RHEA:21748	skos:altLabel	"lactaldehyde dehydrogenase (NADP(+))"
RHEA:21748	skos:altLabel	"methylglyoxal reductase (NADPH-dependent)"
REACT:R-SSC-917814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Sus scrofa)
RHEA:22969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + CoA + NAD(+) => butanoyl-CoA + H(+) + NADH
REACT:R-HSA-5637794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFRvIII does not bind CBL (Homo sapiens)
REACT:R-SSC-5649726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Sus scrofa)
RHEA:43210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine => carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine
REACT:R-DRE-1067676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST-2 (Danio rerio)
RHEA:21209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-serine => L-serine + phosphate
REACT:R-CFA-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Canis familiaris)
REACT:R-SSC-159194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Sus scrofa)
REACT:R-RNO-6814096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds SCOC (Rattus norvegicus)
REACT:R-RNO-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Rattus norvegicus)
RHEA:57547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1
RHEA:56893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose => NADP(+) + UDP-beta-L-rhamnose
RHEA:38628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-DRE-5624949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the anterograde IFT train (Danio rerio)
REACT:R-RNO-8951595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Rattus norvegicus)
RHEA:47481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
RHEA:53421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine => H(+) + roseoflavin + S-adenosyl-L-homocysteine
REACT:R-RNO-6805479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53RK phosphorylates TP53 (Rattus norvegicus)
REACT:R-PFA-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Plasmodium falciparum)
REACT:R-DRE-351210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Danio rerio)
RHEA:23973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-glutaconyl-CoA + H(+) + Na(+)(in) => (2E)-butenoyl-CoA + CO2 + Na(+)(out)
REACT:R-CEL-8851827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Caenorhabditis elegans)
REACT:R-BTA-373342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3CR1 binds CX3CL1 (Bos taurus)
REACT:R-DRE-6784861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG binds LPL dimer (Danio rerio)
RHEA:47153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate + H2O + NAD(+) => 2-oxoglutarate + 2 H(+) + NADH
REACT:R-XTR-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-SSC-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)
GO:0050132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylalanine dehydrogenase activity
GO:0050132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)
GO:0047204	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity
GO:0047204	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorogenate:glucarate caffeoyltransferase activity
GO:0047204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorogenate-glucarate O-hydroxycinnamoyltransferase activity
GO:0047204	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorogenic acid:glucaric acid O-caffeoyltransferase activity
REACT:R-RNO-1254248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80:YAP1 complex to the nucleus (Rattus norvegicus)
REACT:R-SCE-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Saccharomyces cerevisiae)
RHEA:57535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-RNA + ATP + H(+) <=> a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate
RHEA:68885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + ATP + H(+) + NADPH => 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)
REACT:R-CEL-217258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO2:FAD:Mg2+ S-oxidises MTZ (Caenorhabditis elegans)
REACT:R-DRE-1237047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ hydrates CO2 to HCO3- (Danio rerio)
REACT:R-SSC-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Sus scrofa)
REACT:R-XTR-9731613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Xenopus tropicalis)
RHEA:30490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-isoleucine <=> (1E,2S)-2-methylbutanal oxime + CO2 + H2O
RHEA:15339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + phenylglyoxylate => H2O + phenylglyoxylyl-CoA
REACT:R-DDI-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)
REACT:R-MMU-5423678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 hydroxylates AFB1 to AFM1 (Mus musculus)
REACT:R-XTR-1250353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
RHEA:44877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,3-diacylglycerol + H2O => 3-acyl-sn-glycerol + a fatty acid + H(+)
REACT:R-RNO-9014641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Rattus norvegicus)
REACT:R-RNO-203774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Csk with PAG (Rattus norvegicus)
RHEA:45026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + 2 H2O + NADP(+) => cholesterol + H(+) + NADPH + O2
REACT:R-BTA-5621370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Bos taurus)
GO:0102829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ajugose synthase activity
RHEA:60176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O = 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate
RHEA:25914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-5-ol
REACT:R-DRE-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Danio rerio)
RHEA:64902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphate + UDP => H2O + UTP
RHEA:71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate(in) => glycoursodeoxycholate(out)
RHEA:72922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II
REACT:R-HSA-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)
RHEA:30820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoin + H2O => allantoate + H(+)
RHEA:22472	skos:prefLabel	"pantetheine kinase"
RHEA:22472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantetheine + ATP = (R)-4'-phosphopantetheine + ADP + H(+)
RHEA:22472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pantetheine kinase"
REACT:R-DRE-8938073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Danio rerio)
REACT:R-SSC-6804942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 homodimers auto-ubiquitinate (Sus scrofa)
EC:6.2.1.-	skos:prefLabel	"Acid--thiol ligases"
EC:6.2.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acid--thiol ligases"
RHEA:20627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c3] + 2 H(+) => 2 Fe(III)-[cytochrome c3] + H2
GO:0103086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiopentylmalate isomerase activity
RHEA:33399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) = L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)
RHEA:33399	skos:altLabel	"N-acetylmuramic acid PTS permease"
RHEA:33399	skos:prefLabel	"protein-N(pi)-phosphohistidine--N-acetylmuramate phosphotransferase"
RHEA:33399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--N-acetylmuramate phosphotransferase"
GO:0140482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron sensor activity
REACT:R-MMU-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Mus musculus)
REACT:R-HSA-1605591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Homo sapiens)
REACT:R-SSC-8876366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL translocates from endosome lumen to lysosome lumen (Sus scrofa)
RHEA:46659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADPH <=> 5beta-androstane-3,17-dione + NADP(+)
REACT:R-DME-390124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATS binds to HPO dimer (Drosophila melanogaster)
REACT:R-DDI-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Dictyostelium discoideum)
RHEA:65765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O => (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)
REACT:R-HSA-9636461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtpA binds Ubiquitin (Homo sapiens)
REACT:R-GGA-8944230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Gallus gallus)
REACT:R-GGA-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Gallus gallus)
RHEA:47962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + phosphate => H2O + N(tele)-phospho-L-histidyl-[protein]
REACT:R-CEL-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)
REACT:R-CFA-5693153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1K dephosphorylates p-BCKDH (Canis familiaris)
RHEA:51445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine
RHEA:15010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + NADP(+) => 7,8-dihydrofolate + H(+) + NADPH
REACT:R-DRE-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Danio rerio)
REACT:R-XTR-8959510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPHS2 phosphorylates H2Se to form SELP (Xenopus tropicalis)
RHEA:64341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one => 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate
REACT:R-CFA-211191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF with alpha:beta importin (Canis familiaris)
REACT:R-XTR-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Xenopus tropicalis)
RHEA:55485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:42407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lactose 6-phosphate <=> beta-D-glucose + D-galactose 6-phosphate
RHEA:12594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
REACT:R-HSA-5685604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF6 binds SLAMF6 (Homo sapiens)
REACT:R-CEL-209925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIT and MIT combine to form triiodothyronine (Caenorhabditis elegans)
RHEA:63719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	losartan + UDP-alpha-D-glucuronate <=> losartan-1-N-beta-D-glucuronide + UDP
REACT:R-HSA-2327909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN binds collagen I, II, III, VI fibrils (Homo sapiens)
RHEA:55901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + L-tryptophan + O2 => 6-chloro-L-tryptophan + FAD + 2 H2O
REACT:R-GGA-936960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)
REACT:R-MMU-9018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds interacting proteins at the endosome membrane (Mus musculus)
REACT:R-XTR-5675656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA:EDAR binds EDARADD (Xenopus tropicalis)
RHEA:35495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-aminobenzoyl)-L-glutamate = 4-aminobenzoate + L-glutamate
REACT:R-CEL-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Caenorhabditis elegans)
REACT:R-MMU-8849345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Mus musculus)
REACT:R-HSA-5654510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 binds SPRED1/2 (Homo sapiens)
REACT:R-SSC-352232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)
RHEA:46461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:17712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-nonaprenyl diphosphate <=> 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate
RHEA:58437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentan-1-ol + NADP(+) => 4-methylpentanal + H(+) + NADPH
RHEA:55975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ethanol <=> CoA + ethyl acetate
REACT:R-XTR-9021523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWP2 ubiquitinates NOTCH3 (Xenopus tropicalis)
REACT:R-DDI-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Dictyostelium discoideum)
REACT:R-HSA-177157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Homo sapiens)
RHEA:31775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate
RHEA:31309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
REACT:R-DRE-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Danio rerio)
REACT:R-DME-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)
REACT:R-HSA-432688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)
REACT:R-HSA-166223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The proton is delivered to the matrix side (Homo sapiens)
REACT:R-DME-4546387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VDR with SUMO2 (Drosophila melanogaster)
RHEA:55282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinyl tetradecanoate + CoA => 13-cis-retinol + tetradecanoyl-CoA
REACT:R-BTA-173745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3(H2O)-bound Factor B (Bos taurus)
REACT:R-CFA-9011983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Canis familiaris)
REACT:R-RNO-2243931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-lysinonorleucine cross-links (Rattus norvegicus)
RHEA:35308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + salicylate => 2,5-dihydroxybenzoate + H2O + NAD(+)
RHEA:34892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenite(in) => selenite(out)
REACT:R-GGA-2022379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Gallus gallus)
EC:2.4.1.263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"abscisate beta-glucosyltransferase"
EC:2.4.1.263	skos:altLabel	"ABA-glucosyltransferase"
EC:2.4.1.263	skos:altLabel	"ABA-GTase"
EC:2.4.1.263	skos:prefLabel	"abscisate beta-glucosyltransferase"
REACT:R-SSC-194518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoA is activated by nucleotide exchange and inhibits axonal growth (Sus scrofa)
REACT:R-HSA-9758090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)
REACT:R-RNO-8849435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 dephosphorylates PTK6 (Rattus norvegicus)
REACT:R-SSC-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Sus scrofa)
REACT:R-DDI-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Dictyostelium discoideum)
REACT:R-HSA-5693584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
RHEA:17269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"macrocin O-methyltransferase"
RHEA:17269	skos:prefLabel	"macrocin O-methyltransferase"
RHEA:17269	skos:altLabel	"MOMT"
RHEA:17269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrocin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tylosin
RHEA:40342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-MMU-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Mus musculus)
REACT:R-BTA-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Bos taurus)
REACT:R-SSC-170076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Sus scrofa)
REACT:R-SSC-5340251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Sus scrofa)
REACT:R-BTA-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
RHEA:66988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanoate + ATP + CoA = 4-methylpentanoyl-CoA + AMP + diphosphate
REACT:R-HSA-9021847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB1 gene expression is stimulated by MECP2 (Homo sapiens)
REACT:R-MMU-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Mus musculus)
RHEA:64241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + octanoyl-CoA => CoA + H(+) + N-octanoylglycine
RHEA:10953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + hydroxymalonate => (E)-sinapoyltartronate + CoA
RHEA:43600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosanoyl-[ACP] + H(+) + NADPH = 3R-hydroxyeicosanoyl-[ACP] + NADP(+)
REACT:R-BTA-5685319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex formation (Bos taurus)
RHEA:10348	skos:prefLabel	"5-oxoprolinase (ATP-hydrolyzing)"
RHEA:10348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-oxoprolinase (ATP-hydrolyzing)"
RHEA:10348	skos:altLabel	"5-OPase"
RHEA:10348	skos:altLabel	"5-oxo-L-prolinase"
RHEA:10348	skos:altLabel	"pyroglutamase (ATP-hydrolyzing)"
RHEA:10348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate
REACT:R-RNO-209925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIT and MIT combine to form triiodothyronine (Rattus norvegicus)
RHEA:27381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-bisphosphoglycerate 3-phosphatase"
RHEA:27381	skos:prefLabel	"2,3-bisphosphoglycerate 3-phosphatase"
RHEA:27381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate
RHEA:27381	skos:altLabel	"2,3-BPG 3-phosphatase"
RHEA:56007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)
RHEA:44435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acylglycerol <=> a 1,2-diacylglycerol + glycerol
RHEA:20389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)
RHEA:60451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted glutathione + H2O <=> glycine + S-substituted gamma-glutamyl-L-cysteine
REACT:R-SPO-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Schizosaccharomyces pombe)
RHEA:47817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)
RHEA:46940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] = ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate
GO:0001758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinal:NAD+ oxidoreductase activity
GO:0001758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytosolic retinal dehydrogenase activity
GO:0001758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinal dehydrogenase activity
RHEA:48006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O => 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2
REACT:R-MMU-5654640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)
REACT:R-HSA-112149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Abortive Initiation At Type 2 Open Promoters (Homo sapiens)
REACT:R-CFA-193101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11A1 cleaves 20a,22b-DHCHOL (Canis familiaris)
REACT:R-GGA-2173323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by fluid-phase C3i:factor B (Gallus gallus)
EC:4.1.1.83	skos:altLabel	"p-hydroxyphenylacetate decarboxylase"
EC:4.1.1.83	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylacetate decarboxylase"
EC:4.1.1.83	skos:altLabel	"p-Hpd"
EC:4.1.1.83	skos:altLabel	"4-Hpd"
EC:4.1.1.83	skos:altLabel	"4-hydroxyphenylacetate carboxy-lyase"
EC:4.1.1.83	skos:prefLabel	"4-hydroxyphenylacetate decarboxylase"
REACT:R-DME-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Drosophila melanogaster)
RHEA:19757	skos:altLabel	"erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)"
RHEA:19757	skos:altLabel	"erythro-beta-hydroxyaspartate dehydratase"
RHEA:19757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"erythro-3-hydroxy-L-aspartate ammonia-lyase"
RHEA:19757	skos:altLabel	"erythro-3-hydroxyaspartate dehydratase"
RHEA:19757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate
RHEA:19757	skos:prefLabel	"erythro-3-hydroxy-L-aspartate ammonia-lyase"
RHEA:19757	skos:altLabel	"3-hydroxyaspartate dehydratase"
REACT:R-CFA-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Canis familiaris)
REACT:R-HSA-1454699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
RHEA:19617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Rattus norvegicus)
REACT:R-RNO-195690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Rattus norvegicus)
RHEA:22055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + NH4(+) <=> AH2 + H(+) + hydroxylamine
RHEA:60422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => H2O + triglucosyl-enterobactin
RHEA:64003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine
REACT:R-HSA-374673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds RanBPM (Homo sapiens)
RHEA:40899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
REACT:R-RNO-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Rattus norvegicus)
RHEA:44035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxy-(12Z)-octadecenoate + H2O <=> 9,10-dihydroxy-(12Z)-octadecenoate
RHEA:62531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigoxin + 2 Fe(III)-[cytochrome c]
REACT:R-DDI-73632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Dictyostelium discoideum)
RHEA:12189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) => (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2
RHEA:63183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 O2 <=> H(+) + NADP(+) + 2 superoxide
REACT:R-HSA-1471338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 1, 4A and 103 bind CCR6 (Homo sapiens)
RHEA:56655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate-2-oxoglutarate-transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate-oxalate transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate-glutamate aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-aspartate transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic-oxalacetic transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxaloacetate transferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-aspartic aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate:2-oxoglutarate aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate-2-ketoglutarate aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate-oxalacetate aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic--aspartic transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transaminase A activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate oxaloacetate transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aspartate aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate-alpha-ketoglutarate transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic--oxaloacetic transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aspartic acid aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate alpha-ketoglutarate transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GOT (enzyme)
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aspartyl aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AspT
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aspartic aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate-2-oxoglutarate aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate-2-oxoglutarate transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aspartate transaminase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxaloacetate-aspartate aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic-aspartic aminotransferase activity
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AAT
GO:0004069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic oxalic transaminase activity
REACT:R-CFA-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Canis familiaris)
REACT:R-HSA-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)
REACT:R-DRE-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Danio rerio)
RHEA:66284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tomatidine + UDP-alpha-D-glucose = H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP
REACT:R-XTR-9018573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds activated EGFR (Xenopus tropicalis)
GO:0140327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flippase activity (exoplasmic to cytosolic leaftlet)
GO:0140327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flippase activity
RHEA:13879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + L-glutamate 5-semialdehyde => a 2-oxocarboxylate + L-ornithine
REACT:R-CFA-2213241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of nonameric complex (Canis familiaris)
RHEA:10673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclobutadithymidine in DNA => a thymidine dimer in DNA
REACT:R-MMU-2473596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP15 (Mus musculus)
RHEA:43625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomalonate semialdehyde + H(+) => aminoacetaldehyde + CO2
REACT:R-BTA-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Bos taurus)
RHEA:71128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-glutamine(out) + Na(+)(out) => H(+)(out) + L-glutamine(in) + Na(+)(in)
RHEA:20730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H2O2 + NH4(+) => H2O + L-glutamate + O2
REACT:R-GGA-389026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galanin receptors can bind galanin (Gallus gallus)
RHEA:50129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D1 => 17-oxoresolvin D1 + H(+) + NADH
REACT:R-XTR-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Xenopus tropicalis)
REACT:R-MMU-4085347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO1 (Mus musculus)
RHEA:66878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate
REACT:R-HSA-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-CFA-2993447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6x(PCCA:PCCB) (Canis familiaris)
RHEA:66257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + IC-asc-C7 => diphosphate + IC-asc-C7-AMP
RHEA:34345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone => (20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-SSC-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Sus scrofa)
REACT:R-DRE-879411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Danio rerio)
RHEA:23105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose 5-phosphate => D-ribulose 5-phosphate
REACT:R-SSC-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Sus scrofa)
REACT:R-XTR-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:38609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate-adenine dinucleotide phosphate => 2'-phospho-cyclic ADP-ribose + nicotinate
RHEA:52693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenyllactate + NADP(+) => 3-phenylpyruvate + H(+) + NADPH
RHEA:43200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:43200	skos:prefLabel	"23S rRNA (cytidine(1920)-2'-O)-methyltransferase"
RHEA:43200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (cytidine(1920)-2'-O)-methyltransferase"
REACT:R-DRE-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Danio rerio)
REACT:R-MMU-1295540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Mus musculus)
GO:0004471	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD-malic enzyme activity
GO:0004471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)
GO:0004471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate dehydrogenase (oxaloacetate-decarboxylating) activity
GO:0004471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	'malic' enzyme
GO:0004471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-specific malic enzyme
GO:0004471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate:NAD+ oxidoreductase (decarboxylating)
GO:0004471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate dehydrogenase (decarboxylating) activity
GO:0004471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked malic enzyme
GO:0004471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate dehydrogenase (decarboxylating) (NAD+) activity
REACT:R-RNO-5686642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD52 promotes single strand annealing at resected DNA DSBs (Rattus norvegicus)
RHEA:48431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)
REACT:R-DRE-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Danio rerio)
REACT:R-CEL-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Caenorhabditis elegans)
REACT:R-RNO-5684806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates CLEC1B dimer:PDPN (Rattus norvegicus)
RHEA:32607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-hydroxygeranial + H(+) + NADPH
GO:0015275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stretch-activated, cation-selective, calcium channel activity
REACT:R-RNO-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Rattus norvegicus)
REACT:R-MMU-5624473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Mus musculus)
REACT:R-SCE-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Saccharomyces cerevisiae)
REACT:R-HSA-4641231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE recruits HDAC1 to WNT promoters (Homo sapiens)
REACT:R-CFA-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Canis familiaris)
REACT:R-DME-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)
REACT:R-GGA-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Gallus gallus)
RHEA:69108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine
GO:0018809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-phenylitaconyl-CoA hydratase activity
RHEA:22508	skos:altLabel	"terminal addition enzyme"
RHEA:22508	skos:prefLabel	"DNA nucleotidylexotransferase"
RHEA:22508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA nucleotidylexotransferase"
RHEA:22508	skos:altLabel	"terminal transferase"
RHEA:22508	skos:altLabel	"terminal deoxyribonucleotidyltransferase"
RHEA:22508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
RHEA:22508	skos:altLabel	"terminal deoxynucleotidyltransferase"
REACT:R-GGA-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Gallus gallus)
REACT:R-HSA-1222417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TrxA reactivates AhpC (Homo sapiens)
REACT:R-CEL-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Caenorhabditis elegans)
GO:0071558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B demethylates H3K27me3 on p16INK4A promoter (Homo sapiens)
GO:0071558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H3K27me2 demethylase activity
GO:0071558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27me2/H3K27me3 demethylase activity
GO:0071558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H3K27me3 demethylase activity
GO:0071558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-tri/di-methyl-lysine-27 demethylase activity
GO:0071558	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone demethylase activity (H3-K27 specific)
REACT:R-SSC-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Sus scrofa)
GO:0043761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"archaetidylserine synthase"
GO:0043761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity
GO:0043761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaetidylserine synthase activity
GO:0043761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity
GO:0043761	skos:prefLabel	"archaetidylserine synthase"
GO:0043761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine = 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)
GO:0043761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine = archaetidylserine + CMP + H(+)
RHEA:30757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + carbamoyl phosphate => ATP + carbamate
REACT:R-DRE-9748983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6MP, forming 6MeMP (Danio rerio)
RHEA:27735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate
RHEA:56635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neryl diphosphate <=> 1,8-cineole + diphosphate
RHEA:47391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tetradecanoate ester + H2O <=> an aliphatic alcohol + H(+) + tetradecanoate
REACT:R-XTR-9027627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Xenopus tropicalis)
REACT:R-DME-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Drosophila melanogaster)
REACT:R-SPO-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Schizosaccharomyces pombe)
GO:0035979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AS139 kinase activity
GO:0035979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H2A-S139 specific)
GO:0035979	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histone kinase activity (H2A.x-S139 specific)
RHEA:68185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty acyl-CoA + H2O => a medium chain fatty acid + CoA + H(+)
REACT:R-MMU-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Mus musculus)
REACT:R-MMU-8866304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL binds lipids to form VLDL (Mus musculus)
REACT:R-HSA-1678716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(1) (Homo sapiens)
GO:0003943	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity
GO:0003943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine-4-sulphatase activity
GO:0003943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylsulfatase B
GO:0003943	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinsulfatase
GO:0003943	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylgalactosamine 4-sulfatase activity
GO:0003943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine-4-sulfatase activity
GO:0003943	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylgalactosamine 4-sulfate sulfohydrolase activity
RHEA:50834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2
GO:0102842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming)
REACT:R-CFA-8848658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Canis familiaris)
REACT:R-MMU-8869425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA1A hydrolyses PS to 2-acyl LPS (Mus musculus)
RHEA:38846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-9688456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds FLOT1, FLOT2 (Homo sapiens)
RHEA:25374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + FMN <=> 3-(1-carboxyvinyloxy)anthranilate + FMNH2
REACT:R-DME-9661723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)
RHEA:49977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine
REACT:R-XTR-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-SSC-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Sus scrofa)
GO:0061631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"E2 ubiquitin-conjugating enzyme"
GO:0061631	skos:altLabel	"ubiquitin-conjugating enzyme E2"
GO:0061631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin conjugating enzyme activity
GO:0061631	skos:prefLabel	"E2 ubiquitin-conjugating enzyme"
GO:0061631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HECT E3
GO:0061631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
GO:0061631	skos:altLabel	"ubiquitin-carrier-protein E2"
RHEA:33799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidinol + NAD(+) = H(+) + L-histidinal + NADH
REACT:R-CEL-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Caenorhabditis elegans)
RHEA:54851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexan-3-one + NADPH + O2 <=> H2O + NADP(+) + propyl propanoate
REACT:R-DDI-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Dictyostelium discoideum)
RHEA:51563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-bulbocapnine + S-adenosyl-L-methionine <=> (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine
RHEA:19252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
RHEA:63031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenamide + H2O <=> (15Z)-tetracosenoate + NH4(+)
RHEA:28742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(in) + H(+)(out) <=> Cd(2+)(out) + H(+)(in)
RHEA:29197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + orotate => (S)-dihydroorotate + a menaquinone
RHEA:19281	skos:prefLabel	"psoralen synthase"
RHEA:19281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen
RHEA:19281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"psoralen synthase"
REACT:R-RNO-2002460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB binds Collagen chains (Rattus norvegicus)
RHEA:31972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 => 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)
RHEA:41265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-prostaglandin A1 + H(+) + NADH => NAD(+) + prostaglandin A1
RHEA:64910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + 2 H(+) + 2 phosphate => CTP + 2 H2O
REACT:R-HSA-5625424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The retrograde IFT train dissociates (Homo sapiens)
REACT:R-CFA-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
RHEA:59372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)
RHEA:45427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
GO:0050070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysolecithin acylmutase activity
GO:0050070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysolecithin 2,3-acylmutase activity
GO:0050070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysolecithin migratase activity
RHEA:41285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + tetracosanoate => H2O + N-tetracosanoyl-sphing-4-enine
REACT:R-CFA-2076392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcA to heparan (Canis familiaris)
RHEA:11111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)
RHEA:17130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate
RHEA:68953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoscopoletin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + scoparone
RHEA:47202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH => (24S)-7alpha-dihydroxycholesterol + NAD(+)
RHEA:67249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H2O + NAD(+) => (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH
REACT:R-DRE-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Danio rerio)
REACT:R-CEL-9625482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated EGFR (Caenorhabditis elegans)
GO:0034801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitrocyclohexanone hydrolase activity
REACT:R-MMU-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Mus musculus)
RHEA:12457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + D-ribitol 5-phosphate + H(+) => CDP-L-ribitol + diphosphate
RHEA:62191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate <=> diphosphate + syn-isopimara-7,15-diene
REACT:R-CFA-9014627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDS dimers:PXLP dehydrate L-Thr to 2AA (Canis familiaris)
RHEA:51811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
RHEA:21005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantolactone + A => 2-dehydropantolactone + AH2
RHEA:68341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phospho-S-sulfopantetheine + H2O => (R)-S-sulfopantetheine + phosphate
REACT:R-RNO-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Rattus norvegicus)
RHEA:61281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + H2O + O2 => H2O2 + NH4(+) + succinate semialdehyde
RHEA:50165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5099899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD4 (Bos taurus)
GO:0015328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cystine secondary active transmembrane transporter activity
GO:0015328	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lysosomal cystine transporter
GO:0015328	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cystinosin
GO:0015328	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cystine porter activity
GO:0102888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-cuprenene synthase activity
REACT:R-BTA-420980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Bos taurus)
RHEA:44989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 2-methylpropanoyl-CoA => CoA + O-isobutanoyl-(R)-carnitine
REACT:R-MMU-1369017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in muscle cells (Mus musculus)
RHEA:52640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA
RHEA:30928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O => 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose
REACT:R-SCE-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Saccharomyces cerevisiae)
GO:0022829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-gated, wide pore channel activity
GO:0022829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	wide pore channel activity
GO:0022829	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gap junction activity
REACT:R-CEL-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Caenorhabditis elegans)
RHEA:29466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K(+)(in) <=> K(+)(out)
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DGK activity
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diglyceride kinase activity
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonoyl-specific diacylglycerol kinase activity
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-diacylglycerol kinase (phosphorylating)
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol kinase activity
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-1,2-diacylglycerol kinase activity
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP:diacylglycerol phosphotransferase activity
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-diacylglycerol kinase activity
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	diacylglycerol:ATP kinase activity
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP:1,2-diacylglycerol 3-phosphotransferase activity
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CTP:diacylglycerol kinase activity
GO:0004143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DG kinase activity
RHEA:68532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate
REACT:R-CEL-3159253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAB adenosylates cob(I)alamin (Caenorhabditis elegans)
REACT:R-SSC-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Sus scrofa)
REACT:R-DDI-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Dictyostelium discoideum)
RHEA:65106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene B + holo-[peptidyl-carrier protein] => aculene D + L-prolyl-[peptidyl-carrier protein]
GO:0102384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-O-beta-glucopyranosyl-steviol glucosyltransferase activity
GO:0001216	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
GO:0001216	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding
GO:0001216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-binding transcription activator activity
GO:0001216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001216	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
GO:0001216	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
GO:0001216	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GO:0001216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
RHEA:53645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether B + diphosphate
REACT:R-BTA-211910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Bos taurus)
REACT:R-RNO-4755524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1I2 with SUMO3 (Rattus norvegicus)
REACT:R-HSA-2316347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4A:GTP binds KIF3 and activates KIF3 (Homo sapiens)
REACT:R-SSC-2730862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of LYN kinase (Sus scrofa)
RHEA:43503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucuronate + NAD(+) <=> D-glucaro-1,5-lactone + H(+) + NADH
REACT:R-DRE-5368580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Danio rerio)
REACT:R-CFA-372693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
RHEA:46751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyphosphate + NH4(+) <=> carbamate + 2 H(+) + phosphate
RHEA:21601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + benzoyl-CoA => CoA + N-benzoylanthranilate
RHEA:43270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 + H(+) + UDP => ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-BTA-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Bos taurus)
REACT:R-HSA-2220982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
RHEA:70316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine
RHEA:43148	skos:altLabel	"tRNA(m(1)G(9)/m(1)A(9))-methyltransferase"
RHEA:43148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine
RHEA:43148	skos:prefLabel	"tRNA (adenine(9)-N(1))-methyltransferase"
RHEA:43148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (adenine(9)-N(1))-methyltransferase"
RHEA:43148	skos:altLabel	"tRNA m(1)A(9)-methyltransferase"
REACT:R-CFA-5654614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
REACT:R-XTR-9709406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to Cytochrome c oxidase (Xenopus tropicalis)
RHEA:64837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethanol + acetyl-CoA => CoA + phenethyl acetate
RHEA:35162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol
REACT:R-HSA-2294574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Condensin II-mediated condensation of prophase chromosomes (Homo sapiens)
RHEA:70614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + tetradecanoyl-[ACP] <=> H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]
REACT:R-DRE-5674019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds KSR1:MARK3 (Danio rerio)
REACT:R-DME-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Drosophila melanogaster)
RHEA:35634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin + UDP-alpha-D-galactose <=> cyanidin 3-O-beta-D-galactoside + H(+) + UDP
RHEA:21316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phorbol-diester hydrolase"
RHEA:21316	skos:prefLabel	"phorbol-diester hydrolase"
RHEA:21316	skos:altLabel	"diacylphorbate 12-hydrolase"
RHEA:21316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate
REACT:R-CFA-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Canis familiaris)
RHEA:68349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP => diphosphate + pppA(2'-5')pG
REACT:R-CFA-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Canis familiaris)
REACT:R-GGA-2473186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FSTL3 binds Activin (Gallus gallus)
RHEA:32087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate = [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate
RHEA:32087	skos:prefLabel	"Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase"
RHEA:32087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase"
RHEA:62454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-glutamate
REACT:R-CFA-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Canis familiaris)
RHEA:60131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate
RHEA:34156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose
RHEA:30875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + D-glutamate
REACT:R-HSA-211910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)
REACT:R-SSC-877187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates loss of intracellular K+ (Sus scrofa)
RHEA:22255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer (d18:1(4E)) + H(+) + UDP
REACT:R-HSA-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Homo sapiens)
RHEA:50423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] <=> H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)
RHEA:69062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+) => N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2
REACT:R-CEL-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Caenorhabditis elegans)
REACT:R-SPO-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Schizosaccharomyces pombe)
RHEA:65976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + hnu = previtamin D3
RHEA:53346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NADP(+)
RHEA:53199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Schizosaccharomyces pombe)
REACT:R-BTA-9661432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds ALB (Bos taurus)
RHEA:31323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosylglucosyl-3-phosphoglycerate synthase"
RHEA:31323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)
RHEA:31323	skos:prefLabel	"mannosylglucosyl-3-phosphoglycerate synthase"
GO:0016901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO:0016901	skos:prefLabel	"With a quinone or similar compound as acceptor"
GO:0016901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
REACT:R-SSC-6783670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1 binds CLCF1 (Sus scrofa)
REACT:R-SSC-378513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Sus scrofa)
RHEA:45210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein]
REACT:R-HSA-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Homo sapiens)
REACT:R-DRE-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Danio rerio)
REACT:R-RNO-8854604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D16 accelerates GTP hydrolysis by RAB4A (Rattus norvegicus)
RHEA:10173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoate dimer + H2O => 2 (R)-3-hydroxybutanoate + H(+)
REACT:R-HSA-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Homo sapiens)
REACT:R-HSA-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)
REACT:R-CFA-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Canis familiaris)
REACT:R-CFA-2404131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)
REACT:R-RNO-209760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Rattus norvegicus)
REACT:R-DME-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Drosophila melanogaster)
REACT:R-SPO-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Schizosaccharomyces pombe)
RHEA:29594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate + NADP(+) <=> H(+) + NADPH + sulfoacetaldehyde
REACT:R-MMU-5603467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C is released from PROCR (Mus musculus)
REACT:R-MMU-6810594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Mus musculus)
REACT:R-HSA-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Homo sapiens)
RHEA:52304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-ectoine = (2S)-2-acetamido-4-aminobutanoate
RHEA:52304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ectoine hydrolase"
RHEA:52304	skos:prefLabel	"ectoine hydrolase"
RHEA:33950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine <=> 2'-N-acetylparomamine + H(+) + UDP
GO:0016041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate synthase (ferredoxin) activity
GO:0016041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin-glutamate synthase activity
GO:0016041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate synthase (ferredoxin-dependent)
GO:0016041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin-dependent glutamate synthase activity
GO:0016041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:ferredoxin oxidoreductase (transaminating)
REACT:R-DME-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Drosophila melanogaster)
RHEA:17379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) => a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein]
REACT:R-RNO-167427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid dissociates from MOR (Rattus norvegicus)
GO:1990609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-cysteine ligase regulator activity
GO:0047532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-dioxopiperazine amidohydrolase activity
GO:0047532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclo(Gly-Gly) hydrolase activity
GO:0047532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopiperazine hydrolase activity
GO:0047532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclo(glycylglycine) hydrolase activity
REACT:R-CFA-2730841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV (Canis familiaris)
REACT:R-SSC-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Sus scrofa)
REACT:R-DDI-390438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR2 reduces PalmCoA to HXOL (Dictyostelium discoideum)
REACT:R-HSA-8877760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Homo sapiens)
RHEA:51140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate
REACT:R-DME-2160931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of tight junctions (Drosophila melanogaster)
RHEA:70128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Danio rerio)
REACT:R-RNO-2029458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)
GO:0102049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-methionine synthetase activity
REACT:R-DME-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Drosophila melanogaster)
REACT:R-HSA-9759176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent HMOX1 gene expression (Homo sapiens)
REACT:R-DME-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Drosophila melanogaster)
RHEA:72221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 hydrogencarbonate(in) + Na(+)(in) => 3 hydrogencarbonate(out) + Na(+)(out)
REACT:R-BTA-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Bos taurus)
RHEA:55574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine
REACT:R-DDI-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Dictyostelium discoideum)
GO:0034011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity
GO:0034011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CuyA
GO:0034011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteate sulfo-lyase activity
GO:0034011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteate sulfo-lyase (deaminating) activity
RHEA:60892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O = a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)
REACT:R-SSC-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Sus scrofa)
RHEA:33653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate => (9Z,12Z)-octadecadienoate + ATP + CoA
REACT:R-SSC-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Sus scrofa)
RHEA:14714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + keto-L-sorbose => 5-dehydro-D-fructose + AH2
RHEA:65345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA => (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:35660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose => GDP + H(+) + mannosylinositol phosphorylphytoceramide
REACT:R-BTA-8938073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Bos taurus)
RHEA:25027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + S-methyl-5'-thioinosine => H(+) + H2O + S-methyl-5'-thioadenosine
REACT:R-SSC-77593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage and polyadenylation of Intronless Pre-mRNA (Sus scrofa)
REACT:R-DRE-508451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B is phosphorylated (Danio rerio)
REACT:R-MMU-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
RHEA:19318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate
REACT:R-CFA-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Canis familiaris)
REACT:R-RNO-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Rattus norvegicus)
REACT:R-HSA-195733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M2 protein synthesis (Homo sapiens)
REACT:R-SPO-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Schizosaccharomyces pombe)
RHEA:72757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-c-tri-AMP + 3 diphosphate => 3 ATP
GO:0050582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylitol:oxygen oxidoreductase activity
GO:0050582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylitol oxidase activity
REACT:R-GGA-374909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabolism of Noradrenaline (Gallus gallus)
REACT:R-BTA-113402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:early elongation complex (Bos taurus)
RHEA:45097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CEL-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Caenorhabditis elegans)
RHEA:64126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + L-phenylalanine => H2O + N-hexadecanoyl-L-phenylalanine
EC:3.2.1.14	skos:altLabel	"poly-beta-glucosaminidase"
EC:3.2.1.14	skos:prefLabel	"chitinase"
EC:3.2.1.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chitinase"
EC:3.2.1.14	skos:altLabel	"1,4-beta-poly-N-acetylglucosaminidase"
EC:3.2.1.14	skos:altLabel	"chitodextrinase"
GO:0051065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP reductase activity
GO:0051065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a disulfide as acceptor"
GO:0051065	skos:prefLabel	"With a disulfide as acceptor"
GO:0051065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP reduction
REACT:R-XTR-9691174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the ER membrane (Xenopus tropicalis)
RHEA:40640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-DDI-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Dictyostelium discoideum)
REACT:R-CEL-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
REACT:R-PFA-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Plasmodium falciparum)
RHEA:11718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate + NH4(+) => a monoamide of a dicarboxylate + H2O
RHEA:62575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine <=> glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine
RHEA:21933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine => homoserine lactone + S-methyl-5'-thioadenosine
REACT:R-XTR-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Xenopus tropicalis)
REACT:R-MMU-4755478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates IKBKE with SUMO1 (Mus musculus)
REACT:R-XTR-112436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin complex (Xenopus tropicalis)
REACT:R-CEL-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Caenorhabditis elegans)
REACT:R-RNO-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Rattus norvegicus)
RHEA:22094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin]
RHEA:64905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + 2 H2O => GMP + 2 H(+) + 2 phosphate
REACT:R-BTA-186778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 binds to the active receptor (Bos taurus)
GO:0140490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule nucleation template activity
GO:0140490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule nucleator activity
GO:0102506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity
RHEA:67526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine => 4,8-dimethylnonanoyl-CoA + H2O
REACT:R-GGA-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
RHEA:14889	skos:altLabel	"eicosapentaenoate cis-Delta(5,8,11,14,17)-eicosapentaenoate cis-Delta(5)-trans-Delta(7,9)-cis-Delta(14,17) isomerase"
RHEA:14889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate
RHEA:14889	skos:prefLabel	"polyenoic fatty acid isomerase"
RHEA:14889	skos:altLabel	"PFI"
RHEA:14889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polyenoic fatty acid isomerase"
REACT:R-CEL-4332358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CaM and CAMK2 autophosphorylation (Caenorhabditis elegans)
REACT:R-RNO-210290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHIP (Rattus norvegicus)
REACT:R-MMU-6794347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 dimerizes (Mus musculus)
REACT:R-CFA-9726875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCNs:cAMP bind SNIs (Canis familiaris)
GO:0047244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP
GO:0047244	skos:prefLabel	"N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase"
GO:0047244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase"
GO:0047244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity
GO:0047244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity
GO:0047244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylmannosaminyltransferase activity
GO:0047244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity
GO:0047244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity
REACT:R-MMU-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Mus musculus)
REACT:R-BTA-2534359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CatSper Channel Mediated Calcium Transport (Bos taurus)
EC:2.3.2.9	skos:prefLabel	"agaritine gamma-glutamyltransferase"
EC:2.3.2.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"agaritine gamma-glutamyltransferase"
REACT:R-MMU-5654603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS3 (Mus musculus)
RHEA:70395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + docosanoyl-CoA = CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine
GO:0047624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine-tetraphosphatase activity
GO:0047624	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine-tetraphosphate phosphohydrolase activity
GO:0047624	skos:prefLabel	"adenosine-tetraphosphatase"
GO:0047624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-tetraphosphate + H2O = ATP + H(+) + phosphate
GO:0047624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosine-tetraphosphatase"
RHEA:21911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + scytalone <=> H(+) + NADPH + naphthalene-1,3,6,8-tetrol
REACT:R-PFA-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Plasmodium falciparum)
GO:0001025	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA polymerase III transcription factor binding
GO:0001025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III general transcription initiation factor binding
RHEA:54836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptan-2-one + NADPH + O2 = H2O + NADP(+) + pentyl acetate
RHEA:43801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-RNO-1604690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MMP9 intermediate form by MMPs (Rattus norvegicus)
RHEA:64150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate
RHEA:37781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
GO:0015373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anion:sodium symporter activity
GO:0015373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monovalent anion:sodium symporter activity
REACT:R-XTR-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Xenopus tropicalis)
RHEA:21766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase] => heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-5579023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA2(869-1464) binds KAT6A(1-1118) (Rattus norvegicus)
REACT:R-XTR-74220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Xenopus tropicalis)
RHEA:59174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase]
RHEA:47372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + D-glucose = a quinol + D-glucono-1,5-lactone
RHEA:47372	skos:prefLabel	"glucose 1-dehydrogenase (FAD, quinone)"
RHEA:47372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose 1-dehydrogenase (FAD, quinone)"
RHEA:47372	skos:altLabel	"glucose dehydrogenase (Aspergillus)"
RHEA:47372	skos:altLabel	"FAD-dependent glucose dehydrogenase"
REACT:R-MMU-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Mus musculus)
RHEA:72771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:59399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine <=> D-leucine
RHEA:21871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)
EC:1.2.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldehyde dehydrogenase (NAD(+))"
EC:1.2.1.3	skos:prefLabel	"aldehyde dehydrogenase (NAD(+))"
REACT:R-DRE-5229273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCN2:2,5DHBA binds Fe3+ (Danio rerio)
REACT:R-MMU-3209165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ID1 sequesters ETS2 (Mus musculus)
REACT:R-CFA-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Canis familiaris)
REACT:R-GGA-434047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylation of IRAK2 by activated IRAK4  (Gallus gallus)
REACT:R-BTA-2168884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Methemoglobin to Hemopexin (Bos taurus)
REACT:R-DRE-9627078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP9 (Danio rerio)
GO:0047064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulochrin oxidase activity
GO:0047064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity
GO:0047064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)
REACT:R-GGA-8855564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Gallus gallus)
REACT:R-DDI-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Dictyostelium discoideum)
RHEA:28573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine <=> diphosphate + L-seryl-5'-AMP
REACT:R-HSA-9665417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)
REACT:R-HSA-9674398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D842V PDGFRA doesn't bind sunitinib (Homo sapiens)
REACT:R-CFA-5686704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates DCLRE1C (Canis familiaris)
REACT:R-BTA-390886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH4 binds Hist (Bos taurus)
REACT:R-DRE-202472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TRAF6 to CBM complex (Danio rerio)
REACT:R-CEL-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Caenorhabditis elegans)
REACT:R-BTA-8950181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y693-STAT4 dimer translocates to the nucleus (Bos taurus)
REACT:R-MMU-211882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A7 can 6beta-hydroxylate testosterone (Mus musculus)
REACT:R-HSA-1679589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal full-length TLR9 (Homo sapiens)
REACT:R-MMU-174706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Mus musculus)
REACT:R-SCE-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)
REACT:R-SSC-452122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Sus scrofa)
REACT:R-HSA-9604606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates NICD4 (Homo sapiens)
REACT:R-BTA-1237059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ dehydrates HCO3- to CO2 (Bos taurus)
RHEA:64843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethanol + benzoyl-CoA <=> CoA + phenethyl benzoate
REACT:R-XTR-8848314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36:IL1RL2 binds IL1RAP-1 (Xenopus tropicalis)
GO:0097262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eoxin D4 synthase activity
GO:0097262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXC4 is converted to EXD4 by GGT (Homo sapiens)
RHEA:72310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + taurocholate(out) <=> L-glutamate(out) + taurocholate(in)
RHEA:56194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-CFA-6801675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates NPM1 (Canis familiaris)
REACT:R-SCE-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Saccharomyces cerevisiae)
RHEA:36843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA
REACT:R-MMU-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Mus musculus)
GO:0046625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid binding
RHEA:14555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + cephalosporin C => (7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate
RHEA:56530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-chloro-D-tryptophan + FAD + 2 H2O => chloride + D-tryptophan + FADH2 + O2
REACT:R-GGA-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Gallus gallus)
GO:0103005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxystearate hydrolase activity
RHEA:59015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloartenol + S-adenosyl-L-methionine <=> 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine
RHEA:19565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = diphosphate + sabinene hydrate
RHEA:19565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sabinene-hydrate synthase"
RHEA:19565	skos:prefLabel	"sabinene-hydrate synthase"
RHEA:19565	skos:altLabel	"sabinene hydrate cyclase"
RHEA:17491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => H(+) + NADH + O2 + phthalate
REACT:R-DME-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Drosophila melanogaster)
REACT:R-HSA-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Homo sapiens)
REACT:R-CFA-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Canis familiaris)
REACT:R-DRE-389639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Danio rerio)
REACT:R-SSC-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Sus scrofa)
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sucrose hydrolysis
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrase-isomaltase activity
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose-alpha-D-glucohydrolase activity
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrase activity
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose alpha-D-glucohydrolase activity
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrase(invertase)
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose alpha-glucosidase activity
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	intestinal sucrase activity
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose alpha-glucohydrolase activity
GO:0004575	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis
REACT:R-CEL-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Caenorhabditis elegans)
REACT:R-DME-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Drosophila melanogaster)
REACT:R-GGA-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Gallus gallus)
REACT:R-DRE-194121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-XTR-2534378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hv1 Mediated H+ Permeability (Xenopus tropicalis)
REACT:R-RNO-8849900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs1-3 bind each other in cis interactions (Rattus norvegicus)
RHEA:36801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-phosphate + H(+) + phosphate => a ribonucleoside 5'-diphosphate + H2O
REACT:R-DME-6805650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)
REACT:R-RNO-5649681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL2 cleaves 5-OHU from damaged DNA (Rattus norvegicus)
REACT:R-SPO-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Schizosaccharomyces pombe)
RHEA:23985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + NADP(+) => 7-dehydrocholesterol + H(+) + NADPH
RHEA:21708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylhomocysteinase"
RHEA:21708	skos:altLabel	"S-adenosylhomocysteine hydrolase"
RHEA:21708	skos:altLabel	"S-adenosylhomocysteine synthase"
RHEA:21708	skos:prefLabel	"adenosylhomocysteinase"
RHEA:21708	skos:altLabel	"AdoHcyase"
RHEA:21708	skos:altLabel	"S-adenosylhomocysteinase"
RHEA:21708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine
RHEA:21708	skos:altLabel	"adenosylhomocysteine hydrolase"
RHEA:21708	skos:altLabel	"SAHase"
RHEA:48274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-RNO-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)
REACT:R-XTR-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Xenopus tropicalis)
REACT:R-RNO-8941701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Rattus norvegicus)
REACT:R-HSA-1251944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 binds to p-ERBB2:p-EGFR (Homo sapiens)
REACT:R-DDI-8938073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Dictyostelium discoideum)
REACT:R-CEL-6809264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)
REACT:R-MMU-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Mus musculus)
RHEA:29874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + thiosulfate(out) <=> ADP + H(+) + phosphate + thiosulfate(in)
REACT:R-CFA-2129385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFAP2, MFAP5 bind microfibrils (Canis familiaris)
RHEA:12184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH
RHEA:12184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S,S)-butanediol dehydrogenase"
RHEA:12184	skos:prefLabel	"(S,S)-butanediol dehydrogenase"
RHEA:67131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH <=> (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGA mutase activity
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Homo sapiens)
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bisphosphoglyceromutase
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglycerate mutase activity
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGAM activity
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglycerate phosphomutase activity
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GriP mutase
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monophosphoglycerate mutase activity
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monophosphoglyceromutase activity
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MPGM
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphoglycomutase
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-phosphoglycerate 2,3-phosphomutase activity
GO:0004619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglyceromutase activity
REACT:R-HSA-8878581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYRP1 oxidises DHICA to IQCA (Homo sapiens)
REACT:R-DRE-5671763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates PPP1R14A (Danio rerio)
RHEA:57182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => L-lysyl-[protein] + methylglyoxal
GO:1901265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside phosphate binding
REACT:R-RNO-5689544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds INO80 complex (Rattus norvegicus)
REACT:R-MMU-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Mus musculus)
REACT:R-XTR-8855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR:DAB1 binds SH3KBP1 (Xenopus tropicalis)
RHEA:65192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + 2 O2 + preaustinoid A = berkeleytrione + 2 CO2 + H2O + 2 succinate
RHEA:23458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + crepenynate + 2 H2O => (9Z,12Z)-octadecadienoate + AH2 + O2
RHEA:56444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate
REACT:R-DDI-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Dictyostelium discoideum)
RHEA:12998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + galactarate => 2-O-[(E)-feruloyl]-D-galactarate + CoA
RHEA:43821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-5692764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 binds CCND3 (Rattus norvegicus)
REACT:R-GGA-5655170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 monoubiquitinates POLH (Gallus gallus)
GO:0033019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyvalerate dehydrogenase activity
REACT:R-DDI-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Dictyostelium discoideum)
RHEA:32488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-choline + H2O => CMP + 2 H(+) + phosphocholine
RHEA:22167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Forssman (d18:1(4E)) + H(+) + UDP
REACT:R-GGA-1237047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ hydrates CO2 to HCO3- (Gallus gallus)
REACT:R-XTR-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Xenopus tropicalis)
RHEA:61393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]
REACT:R-DME-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Drosophila melanogaster)
REACT:R-MMU-265682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Mus musculus)
REACT:R-HSA-8950367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of transaldolase 1 (Homo sapiens)
RHEA:12964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + butanoyl-CoA <=> acetoacetyl-CoA + butanoate
REACT:R-GGA-420906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPAT tetramers (Gallus gallus)
RHEA:23439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O <=> 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate
REACT:R-DME-6807826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDHAL6B reduces PYR to LACT (Drosophila melanogaster)
GO:0033987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisoflavanone dehydratase activity
GO:0033987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity
GO:0033987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,7,4'-trihydroxyisoflavanone hydro-lyase activity
REACT:R-RNO-2029271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
RHEA:64209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-glutamine + H2O => a fatty acid + L-glutamine
REACT:R-GGA-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Gallus gallus)
RHEA:32876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + H2O => a fatty acid + glycerol + H(+)
RHEA:42718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate
REACT:R-CFA-2468287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)
REACT:R-MMU-5682858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate H2AFX (Mus musculus)
RHEA:48237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-acetylphloroglucinol => 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)
RHEA:38299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA
REACT:R-DRE-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Danio rerio)
RHEA:64915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate
GO:0032935	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sterol-sensing domain
GO:0032935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol sensing activity
GO:0032935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol sensor activity
REACT:R-RNO-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Rattus norvegicus)
REACT:R-MMU-202216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 (Mus musculus)
REACT:R-SPO-8876446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ULK1 phosphorylates DENND3 (Schizosaccharomyces pombe)
RHEA:43985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)
RHEA:69397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]
REACT:R-CFA-606287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSF complex binds the centromere (Canis familiaris)
RHEA:53150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-5688276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT4 transfers ADPRib to GLUD (Danio rerio)
GO:0102347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-arachidon-2-enoyl-CoA reductase activity
RHEA:36229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline
RHEA:44037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,13-epoxy-(9Z)-octadecenoate + H2O => 12,13-dihydroxy-(9Z)-octadecenoate
REACT:R-BTA-392263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR2 (Bos taurus)
REACT:R-RNO-377640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of SRC (Rattus norvegicus)
REACT:R-SSC-5669250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates FLNA (Sus scrofa)
RHEA:52264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-aminomethylindole N-methyltransferase"
RHEA:52264	skos:prefLabel	"3-aminomethylindole N-methyltransferase"
RHEA:52264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(aminomethyl)indole + 2 S-adenosyl-L-methionine = gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:12603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + L-glutamate => 2-oxoglutarate + L-2-aminoadipate
REACT:R-DRE-109338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Danio rerio)
REACT:R-SSC-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Sus scrofa)
REACT:R-DRE-158750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Danio rerio)
REACT:R-CFA-265428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with VCAM1 (Canis familiaris)
REACT:R-GGA-2574845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA binds centrosome-associated AURKA (Gallus gallus)
REACT:R-DRE-1295632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA2A dephosphorylates SPRY2 (Danio rerio)
REACT:R-SSC-4420099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHB  (Sus scrofa)
REACT:R-PFA-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Plasmodium falciparum)
RHEA:34239	skos:prefLabel	"glutamate 2,3-aminomutase"
RHEA:34239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate = 3-aminopentanedioate
RHEA:34239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate 2,3-aminomutase"
REACT:R-HSA-9664278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)
RHEA:21239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 2 H(+) + NADPH + O2 <=> 2,3-dihydroxybenzoate + NADP(+) + NH4(+)
RHEA:57592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Gallus gallus)
REACT:R-HSA-168337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking and transport of the RNP:Karyopherin complex through the nuclear pore (Homo sapiens)
REACT:R-DRE-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Danio rerio)
GO:1990190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-glutamate-alpha-N-acetyltransferase activity
REACT:R-DDI-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Dictyostelium discoideum)
GO:0018488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryl-aldehyde oxidase activity
GO:0018488	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-aldehyde:oxygen oxidoreductase activity
RHEA:46114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine
RHEA:36284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,7-dimethylxanthine + H(+) + NADPH + O2 => 7-methylxanthine + formaldehyde + H2O + NADP(+)
RHEA:58082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + glycerol + H(+) => 1-docosanoylglycerol + H2O
REACT:R-BTA-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Bos taurus)
REACT:R-DDI-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)
RHEA:53149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Saccharomyces cerevisiae)
RHEA:45988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 = 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O
REACT:R-BTA-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Bos taurus)
REACT:R-SSC-76416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Benzene is hydroxylated to phenol (Sus scrofa)
RHEA:57357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chloride + H(+) + hapalindole U + O2 => CO2 + H2O + hapalindole G + succinate
RHEA:37016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-BTA-174446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap from the C-strand (Bos taurus)
REACT:R-RNO-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Rattus norvegicus)
REACT:R-DME-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Drosophila melanogaster)
RHEA:36492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA
REACT:R-MMU-936960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)
REACT:R-CFA-8870332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Canis familiaris)
REACT:R-DME-202960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of C-IAP1 (Drosophila melanogaster)
REACT:R-RNO-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Rattus norvegicus)
RHEA:61670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-CoA + AMP + diphosphate => ATP + CoA + salicylate
REACT:R-DRE-2990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO1 to UBA2:SAE1 (Danio rerio)
REACT:R-GGA-204861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shc1 (Gallus gallus)
RHEA:17999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-2 + S-adenosyl-L-methionine
GO:0097247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGCG binding
GO:0097247	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	catechin gallate binding
GO:0097247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epigallocatechin 3-gallate binding
GO:0120053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribitol beta-1,4-xylosyltransferase activity
RHEA:12282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP
REACT:R-CEL-446364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Migfilin interacts with VASP (Caenorhabditis elegans)
REACT:R-SSC-9615348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR2 (Sus scrofa)
RHEA:42684	skos:prefLabel	"gamma-glutamyl hercynylcysteine S-oxide hydrolase"
RHEA:42684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide
RHEA:42684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-glutamyl hercynylcysteine S-oxide hydrolase"
REACT:R-RNO-6791235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds AURKA (Rattus norvegicus)
REACT:R-XTR-5690023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL binds 4Fe-4S (Xenopus tropicalis)
RHEA:31353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene + H2O => lupan-3beta,20-diol
RHEA:16408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) <=> benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH
REACT:R-XTR-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Xenopus tropicalis)
GO:0031879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 somatostatin receptor ligand
GO:0031879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 somatostatin receptor binding
REACT:R-SCE-1482546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)
RHEA:51758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-4,6-diprenylphloroglucinol + diphosphate => a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate
RHEA:71363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) = 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)
RHEA:27752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 2'-deoxyinosine + phosphate
GO:0036137	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	kynurenine-oxo-acid transaminase activity
GO:0036137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine transaminase activity
GO:0036137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine aminotransferase activity
RHEA:57559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1
REACT:R-HSA-417908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY1 binds ADP (Homo sapiens)
RHEA:71671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamine(out) + H(+)(out) = glycyl-L-glutamine(in) + H(+)(in)
RHEA:70246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-xylose <=> a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP
REACT:R-DME-9614564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO4 (Drosophila melanogaster)
RHEA:64485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA => 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA
RHEA:54557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-tRNA(His) + ATP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate
REACT:R-DRE-76466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4A11 12-hydroxylates DDCX (Danio rerio)
REACT:R-DRE-5687090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6 phosphorylates NCOA3 (Danio rerio)
REACT:R-HSA-517731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of IL-8 (Homo sapiens)
RHEA:42645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] => diphosphate + holo-[malonate decarboxylase ACP]
REACT:R-MMU-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Mus musculus)
REACT:R-RNO-203662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Rattus norvegicus)
GO:1990583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase D activator activity
RHEA:66301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)
REACT:R-MMU-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Mus musculus)
REACT:R-HSA-2090085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan chain(1) (Homo sapiens)
REACT:R-BTA-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Bos taurus)
REACT:R-CFA-1474210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP14 (Canis familiaris)
REACT:R-BTA-975608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP2:atROL and FACYLs to atREs (Bos taurus)
REACT:R-XTR-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Xenopus tropicalis)
RHEA:30559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O = guanosine + H(+) + triphosphate
REACT:R-HSA-70333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KHK dimer phosphorylates Fru to Fru 1-P (Homo sapiens)
REACT:R-BTA-9756169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)
REACT:R-DRE-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)
REACT:R-BTA-8939801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades PolyUb-RUNX2 (Bos taurus)
RHEA:37132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-DDI-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Dictyostelium discoideum)
RHEA:65689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine
REACT:R-HSA-9624925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-33 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)
REACT:R-HSA-450292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Homo sapiens)
REACT:R-RNO-377643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
RHEA:64348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) = deacetylpyripyropene E
REACT:R-CFA-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Canis familiaris)
EC:3.4.21.101	skos:prefLabel	"xanthomonalisin"
EC:3.4.21.101	skos:altLabel	"sedolisin-B"
EC:3.4.21.101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xanthomonalisin"
EC:3.4.21.101	skos:altLabel	"Xanthomonas aspartic proteinase"
EC:3.4.21.101	skos:altLabel	"xanthomonapepsin"
REACT:R-GGA-8948775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKRN1 polyubiquitinates PTEN (Gallus gallus)
GO:0034323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-butanoyltransferase activity
REACT:R-BTA-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Bos taurus)
REACT:R-DDI-5690046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT2 hydrolyses PALMCoA to PALM (Dictyostelium discoideum)
REACT:R-SSC-2424485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-PLCG1 (Sus scrofa)
REACT:R-GGA-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Gallus gallus)
REACT:R-HSA-3274540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective G6PC does not hydrolyze glucose 6-phosphate (Homo sapiens)
REACT:R-GGA-141316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Gallus gallus)
GO:0005020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stem cell factor receptor activity
GO:0005020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT ligand receptor activity
GO:0005020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KL receptor activity
GO:0005020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KIT
GO:0005020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF receptor activity
RHEA:37155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-RNO-217258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO2:FAD:Mg2+ S-oxidises MTZ (Rattus norvegicus)
REACT:R-HSA-140686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Homo sapiens)
REACT:R-RNO-917839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-Transferrin dissociates from the receptor complex (Rattus norvegicus)
RHEA:42535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(55) in tRNA <=> pseudouridine(55) in tRNA
GO:0047651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylhalidase activity
GO:0047651	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	halogenase activity
GO:0047651	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkyl-halide halidohydrolase activity
GO:0047651	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	haloalkane halidohydrolase activity
REACT:R-XTR-1433374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processing of SCF isoform 1 (Xenopus tropicalis)
RHEA:41201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-BTA-3662335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates histone H2A, H2B, H3, H4 (Bos taurus)
RHEA:32732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)
EC:3.4.24.35	skos:altLabel	"type V collagenase"
EC:3.4.24.35	skos:altLabel	"macrophage gelatinase"
EC:3.4.24.35	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gelatinase B"
EC:3.4.24.35	skos:prefLabel	"gelatinase B"
EC:3.4.24.35	skos:altLabel	"matrix metalloproteinase 9"
EC:3.4.24.35	skos:altLabel	"92-kDa gelatinase"
EC:3.4.24.35	skos:altLabel	"92-kDa type IV collagenase"
RHEA:54018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O
GO:0045438	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ACV synthetase activity
GO:0045438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity
REACT:R-RNO-9749977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A6 glucuronates ST (Rattus norvegicus)
REACT:R-DME-4093327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHA binds TIAM1 (Drosophila melanogaster)
REACT:R-MMU-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Mus musculus)
REACT:R-GGA-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Gallus gallus)
RHEA:33320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-CFA-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Canis familiaris)
RHEA:58747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(7)-methyl-GTP <=> diphosphate + H(+) + N(7)-methyl-GMP
GO:0005314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity L-glutamate transmembrane transporter activity
GO:0005314	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	high-affinity glutamate transmembrane transporter activity
GO:0005314	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	high-affinity glutamate transporter activity
RHEA:37120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine => 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)
RHEA:72863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-cAAG + H2O = G[3'-5']pA[3'-5']pAp[3'] + H(+)
RHEA:31618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine <=> dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-DRE-6805470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates TP53 (Danio rerio)
REACT:R-HSA-9017954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2:SIN3A complex binds OPRM1 gene promoter (Homo sapiens)
REACT:R-RNO-6782138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC5 and RPA bind TC-NER site (Rattus norvegicus)
REACT:R-CFA-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Canis familiaris)
RHEA:62400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-ephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
RHEA:51882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2,3,5-trichloromuconate + H(+) => 3,4,6-trichlorocatechol + O2
RHEA:18580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-193965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 18HCORST to ALDO (Homo sapiens)
REACT:R-DRE-2327746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 aggregation (Danio rerio)
REACT:R-BTA-2473184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follistatin (FST) binds Activin (Bos taurus)
REACT:R-DME-2393954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Drosophila melanogaster)
REACT:R-RNO-9632034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GlcA to chondroitin (Rattus norvegicus)
RHEA:30452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => isomultiflorenol
REACT:R-BTA-5340226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB dioxygenates NO (Bos taurus)
REACT:R-HSA-8935732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)
REACT:R-HSA-6803989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric oxide and O2 react to NO2 (Homo sapiens)
RHEA:24287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate 4-semialdehyde + NADP(+) + phosphate <=> 4-phospho-L-aspartate + H(+) + NADPH
REACT:R-DME-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)
REACT:R-DME-73815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
RHEA:70643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-proline(out) + H(+)(out) = D-proline(in) + H(+)(in)
REACT:R-RNO-5665761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL3 binds RHOC:GTP (Rattus norvegicus)
REACT:R-BTA-4655374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DNMT3B with SUMO1 (Bos taurus)
REACT:R-GGA-508163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Gallus gallus)
REACT:R-SSC-9023619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Sus scrofa)
REACT:R-MMU-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Mus musculus)
RHEA:18304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NH4(+) + XMP <=> AMP + diphosphate + GMP + 2 H(+)
RHEA:43050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-sorbose => keto-D-tagatose
REACT:R-DDI-200423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Dictyostelium discoideum)
REACT:R-RNO-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Rattus norvegicus)
REACT:R-SCE-8847638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Saccharomyces cerevisiae)
RHEA:20307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 H(+) + NADH => 4-hydroxybenzaldehyde + H2O + NAD(+)
RHEA:55949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-alanine + H2O => AH2 + NH4(+) + pyruvate
REACT:R-MMU-3134953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 or DHX9 binds MyD88 (Mus musculus)
RHEA:54525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + H(+) + methylglyoxal => 3-hydroxyhexane-2,5-dione + CO2
REACT:R-MMU-1855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Mus musculus)
REACT:R-SSC-9613264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Sus scrofa)
RHEA:52620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA = 2,2-dimethylpropanoyl-CoA
GO:0047686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylsulfate sulfotransferase activity
GO:0047686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ASST
GO:0047686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenol + an aryl sulfate = a phenol + an aryl sulfate
GO:0047686	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arylsulfotransferase
GO:0047686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aryl-sulfate sulfotransferase"
GO:0047686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylsulfate-phenol sulfotransferase activity
GO:0047686	skos:altLabel	"arylsulfate sulfotransferase"
GO:0047686	skos:prefLabel	"aryl-sulfate sulfotransferase"
GO:0047686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylsulfate:phenol sulfotransferase activity
GO:0047686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylsulphate sulphotransferase activity
GO:0106309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0106309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	progesterone 21-hydroxylase activity
RHEA:13142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA => butanoyl-CoA
REACT:R-XTR-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)
REACT:R-CEL-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Caenorhabditis elegans)
REACT:R-CEL-9654525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Caenorhabditis elegans)
REACT:R-DRE-8867044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EPS15, EPN1, EPS15L1 (Danio rerio)
REACT:R-DME-9761344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 binds IKBKG within IKK complex (Drosophila melanogaster)
REACT:R-GGA-388596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanocortin receptors bind melanocortins (Gallus gallus)
RHEA:50344	skos:prefLabel	"mycolipanoate synthase"
RHEA:50344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycolipanoate synthase"
RHEA:50344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH = 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)
RHEA:50344	skos:altLabel	"mycolipanoic acid synthase"
REACT:R-XTR-2731122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2 & 4 bind VTN (Xenopus tropicalis)
REACT:R-CFA-388833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CTLA-4 (Canis familiaris)
RHEA:62569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-benzyl-L-cysteinylglycine => glycine + S-benzyl-L-cysteine
REACT:R-RNO-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Rattus norvegicus)
RHEA:61922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate => (2R,4S)-ketoconazole(in) + ATP + H2O
GO:0004486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylene-THF dehydrogenase activity
GO:0004486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
GO:0004486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5,N10-methylenetetrahydrofolate dehydrogenase activity
RHEA:13348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]
EC:3.2.1.196	skos:prefLabel	"limit dextrin alpha-1,6-maltotetraose-hydrolase"
EC:3.2.1.196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limit dextrin alpha-1,6-maltotetraose-hydrolase"
EC:3.2.1.196	skos:altLabel	"glycogen debranching enzyme"
REACT:R-SPO-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Schizosaccharomyces pombe)
REACT:R-HSA-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Homo sapiens)
REACT:R-BTA-5682598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates HERC2 (Bos taurus)
REACT:R-SSC-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Sus scrofa)
RHEA:42086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinoate + 2 H(+) + NADH => 9-cis-retinal + H2O + NAD(+)
REACT:R-HSA-9645766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p14ARF mutants do not bind C1QBP (Homo sapiens)
REACT:R-DRE-381446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin proteolyzes IGF:IGFBP3:ALS (Danio rerio)
REACT:R-SSC-2090038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses heparan chain(2) (Sus scrofa)
RHEA:42310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O
RHEA:22278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + 2 H(+) + NADH => 2-oxoaldehyde + H2O + NAD(+)
REACT:R-HSA-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Homo sapiens)
RHEA:45745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydropteroate + NAD(+) => 7,8-dihydropteroate + H(+) + NADH
REACT:R-SCE-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Saccharomyces cerevisiae)
RHEA:37705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA
GO:0050216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanediol-phosphate dehydrogenase activity
REACT:R-MMU-2022368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-42) (Mus musculus)
RHEA:48746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-deoxypodophyllotoxin + CO2 + H2O + succinate => (-)-yatein + 2-oxoglutarate + O2
GO:0015592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose/glucose (methylgalactoside) porter activity
GO:0015592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylgalactoside transmembrane transporter activity
RHEA:19302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine + S-adenosyl-L-methionine => H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine
GO:0008854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gene recBCD enzymes
GO:0008854	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	E. coli exonuclease V activity
GO:0008854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exonuclease V activity
GO:0008854	skos:altLabel	"exonuclease V"
GO:0008854	skos:altLabel	"E.coli exonuclease V"
GO:0008854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gene recBC DNase activity
GO:0008854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gene recBC endoenzyme
GO:0008854	skos:prefLabel	"exodeoxyribonuclease V"
GO:0008854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RecBC deoxyribonuclease activity
GO:0008854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E. coli exonuclease V
GO:0008854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exodeoxyribonuclease V activity
GO:0008854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Escherichia coli exonuclease V
GO:0008854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exodeoxyribonuclease V"
REACT:R-CFA-9014293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GDIs block activation of RAC2 (Canis familiaris)
RHEA:32565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-terpinene + diphosphate => (2E)-geranyl diphosphate
REACT:R-DRE-165708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated 4EBP1 from eIF4E (Danio rerio)
EC:3.5.4.17	skos:prefLabel	"adenosine-phosphate deaminase"
EC:3.5.4.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosine-phosphate deaminase"
GO:0052752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent heterodisulfide oxidoreductase activity
GO:0052752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420-dependent heterodisulfide oxidoreductase activity
GO:0052752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420H2:heterodisulfide oxidoreductase activity
GO:0052752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced coenzyme F420:heterodisulfide oxidoreductase activity
REACT:R-MMU-9680865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4, CYP2B6 bind ritonavir (Mus musculus)
RHEA:59394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-acetyl-L-seryl-[protein] => acetyl-CoA + L-seryl-[protein]
REACT:R-XTR-435244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM1 is phosphorylated (Xenopus tropicalis)
RHEA:17321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine
RHEA:17321	skos:prefLabel	"tryptophan 2-C-methyltransferase"
RHEA:17321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan 2-C-methyltransferase"
REACT:R-HSA-873924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IFNGR1 by JAK kinases (Homo sapiens)
REACT:R-SSC-6809309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR6 binds MTMR9 (Sus scrofa)
RHEA:28211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + O2 => (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate
REACT:R-CFA-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Canis familiaris)
REACT:R-RNO-1504213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Rattus norvegicus)
REACT:R-HSA-936802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to extracellular region (Homo sapiens)
RHEA:65773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-2395873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)
RHEA:54215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphocholine
RHEA:40529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinone + 4 H(+)(out) + 2 H2O(in) => 2 a ubiquinol + 4 H(+)(in) + O2(in)
RHEA:68254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan(out) + Na(+)(out) => L-tryptophan(in) + Na(+)(in)
RHEA:46815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
RHEA:42302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + holo-[ACP] => a fatty acyl-[ACP] + sn-glycerol 3-phosphate
GO:0031073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol 26-hydroxylase activity
RHEA:15435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sophoraflavanone B => (2S)-naringenin + dimethylallyl diphosphate
REACT:R-DRE-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Danio rerio)
RHEA:38017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-geranylgeranyl-2-methylbenzene-1,4-diol => delta-tocotrienol
REACT:R-GGA-2028598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS1 (Gallus gallus)
REACT:R-XTR-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)
RHEA:34301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate => 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate
REACT:R-CFA-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Canis familiaris)
GO:0043906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ala-tRNAPro hydrolase activity
GO:0043906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ala-tRNA(Pro) hydrolase activity
RHEA:52372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:11026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + 2 H(+) + phosphoramidate => ATP + NH4(+)
REACT:R-RNO-5687120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Rattus norvegicus)
REACT:R-GGA-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Gallus gallus)
REACT:R-BTA-8848314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36:IL1RL2 binds IL1RAP-1 (Bos taurus)
RHEA:32331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-endo-fenchol + NAD(+) = (1S,4R)-fenchone + H(+) + NADH
REACT:R-DDI-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Dictyostelium discoideum)
REACT:R-HSA-193452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Homo sapiens)
GO:0102922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylpropanoyltransferase activity
GO:0102922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III = 3'-N-debenzoyl-2'-deoxytaxol + CoA
REACT:R-XTR-9023633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Xenopus tropicalis)
RHEA:47507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NADP(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
GO:0004531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid DNase activity
GO:0004531	skos:altLabel	"lysosomal DNase II"
GO:0004531	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lysosomal DNase II activity
GO:0004531	skos:altLabel	"DNase II"
GO:0004531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNase II activity
GO:0004531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleate 3'-nucleotidohydrolase activity
GO:0004531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid deoxyribonuclease activity
GO:0004531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyribonuclease II"
GO:0004531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonuclease II activity
GO:0004531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pancreatic DNase II
GO:0004531	skos:prefLabel	"deoxyribonuclease II"
REACT:R-BTA-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
REACT:R-HSA-5668731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX3 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
RHEA:48293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + GDP-beta-L-fucose => ganglioside Fuc-GM1 + GDP + H(+)
REACT:R-DME-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Drosophila melanogaster)
RHEA:55239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)
RHEA:18309	skos:prefLabel	"N-acyl-D-amino-acid deacylase"
RHEA:18309	skos:altLabel	"D-aminoacylase"
RHEA:18309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-amino acid + H2O = a carboxylate + a D-alpha-amino acid
RHEA:18309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acyl-D-amino-acid deacylase"
RHEA:16563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hopan-22-ol => H2O + squalene
RHEA:21220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)
RHEA:21220	skos:prefLabel	"stizolobate synthase"
RHEA:21220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stizolobate synthase"
GO:0047878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythritol kinase (phosphorylating)
GO:0047878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythritol kinase activity
GO:0047878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:erythritol 4-phosphotransferase activity
REACT:R-CFA-6799409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates TP53 (Canis familiaris)
REACT:R-RNO-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Rattus norvegicus)
RHEA:62473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine
RHEA:63269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-193070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)
REACT:R-RNO-196857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK2 phosphorylates PanK (Rattus norvegicus)
REACT:R-GGA-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Gallus gallus)
REACT:R-SSC-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Sus scrofa)
REACT:R-MMU-6804266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TTC5 (Mus musculus)
RHEA:61959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-173680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C5 (Mus musculus)
RHEA:10205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] => formaldehyde + methylamine + reduced [electron-transfer flavoprotein]
RHEA:22139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 <=> chlorophyllide b + 2 H2O + NADP(+)
REACT:R-HSA-9624668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDKN1A (p21) (Homo sapiens)
REACT:R-CFA-400037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi,Go Heterotrimeric G-protein complex dissociates (Canis familiaris)
REACT:R-RNO-202500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of IKK complex (Rattus norvegicus)
RHEA:28829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(in) + putrescine(out) => L-ornithine(out) + putrescine(in)
GO:0009918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol delta7 reductase activity
GO:0009918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol delta-7 reductase activity
GO:0031777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 melanin-concentrating hormone receptor binding
GO:0031777	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 melanin-concentrating hormone receptor ligand
RHEA:47204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-DME-156723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF20A (MKL2) by phosphorylation (Drosophila melanogaster)
RHEA:64858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + phomopsene => (2E,6E,10E)-geranylgeranyl diphosphate
RHEA:55771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + UDP-alpha-D-glucuronate <=> all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP
RHEA:62065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose 6-phosphate + NAD(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH
RHEA:67370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-glutamine => H2O + N-acetyl-L-glutamine
REACT:R-CEL-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Caenorhabditis elegans)
REACT:R-CFA-177937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of EGFR by SRC kinase (Canis familiaris)
RHEA:72799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-homoarginine(in) = L-arginine(in) + L-homoarginine(out)
REACT:R-RNO-9640254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Rattus norvegicus)
REACT:R-CEL-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Caenorhabditis elegans)
REACT:R-RNO-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Rattus norvegicus)
REACT:R-HSA-5690669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds itself to form homo-oligomers (Homo sapiens)
REACT:R-XTR-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Xenopus tropicalis)
RHEA:68244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) + Na(+)(out)
REACT:R-SSC-193705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta phosphorylates IkB causing NF-kB to dissociate (Sus scrofa)
REACT:R-DRE-8866269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB bind GPCRs (Danio rerio)
REACT:R-CFA-9759169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Canis familiaris)
RHEA:49184	skos:altLabel	"bciC (gene name)"
RHEA:49184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H(+) + H2O = 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol
RHEA:49184	skos:prefLabel	"chlorophyllide a hydrolase"
RHEA:49184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorophyllide a hydrolase"
GO:0004743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate kinase"
GO:0004743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:pyruvate 2-O-phosphotransferase activity
GO:0004743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate kinase activity
GO:0004743	skos:prefLabel	"pyruvate kinase"
GO:0004743	skos:altLabel	"phosphoenol transphosphorylase"
GO:0004743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate kinase activity
GO:0004743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenol transphosphorylase activity
GO:0004743	skos:altLabel	"phosphoenolpyruvate kinase"
REACT:R-MMU-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Mus musculus)
REACT:R-CFA-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Canis familiaris)
REACT:R-MMU-8848758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates AKT1 (Mus musculus)
RHEA:29514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-valencene + diphosphate
GO:0060422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-dipeptidase inhibitor activity
REACT:R-SSC-9757954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4BP1 binds IKBKG (Sus scrofa)
REACT:R-HSA-450031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Homo sapiens)
RHEA:56811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] <=> adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate
REACT:R-XTR-156661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Exon Junction Complex (Xenopus tropicalis)
RHEA:24783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-13(2)-carboxypyropheophorbide a + H(+) <=> CO2 + pyropheophorbide a
RHEA:54091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + H(+) + NADH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)
REACT:R-DRE-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Danio rerio)
RHEA:32440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:10157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:63220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine = 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine
REACT:R-CEL-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Caenorhabditis elegans)
REACT:R-SPO-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Schizosaccharomyces pombe)
REACT:R-XTR-201425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Xenopus tropicalis)
RHEA:21984	skos:prefLabel	"choline sulfotransferase"
RHEA:21984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate + H(+)
RHEA:21984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choline sulfotransferase"
GO:1990649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity
RHEA:20897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + urea => ADP + H(+) + phosphate + urea-1-carboxylate
RHEA:16328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phospho-alpha-D-glucuronate + H(+) + UTP <=> diphosphate + UDP-alpha-D-glucuronate
RHEA:15196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + H2O <=> 2'-deoxyguanosine + H(+) + triphosphate
REACT:R-RNO-186778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 binds to the active receptor (Rattus norvegicus)
RHEA:15270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylo-hex-3-ulonolactone => H(+) + L-ascorbate
REACT:R-SSC-5218804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK activation by VEGFR (Sus scrofa)
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	microsomal epoxide hydratase activity
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	epoxide hydratase activity
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Homo sapiens)
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-stilbene-oxide hydrolase activity
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	microsomal epoxide hydrase activity
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	benzo[a]pyrene-4,5-oxide hydratase activity
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mEH
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	benzo(a)pyrene-4,5-epoxide hydratase activity
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	microsomal epoxide hydrolase activity
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	epoxide hydrase activity
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aryl epoxide hydrase activity
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-epoxide hydrolase activity
GO:0033961	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arene-oxide hydratase activity
RHEA:56197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP
REACT:R-CFA-5654641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
REACT:R-DRE-451311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca-permeable Kainate receptors (Danio rerio)
RHEA:47640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine
REACT:R-MMU-2046298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to a branch of keratan (Mus musculus)
REACT:R-SSC-140872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Sus scrofa)
REACT:R-XTR-420592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectin-like (Necl) proteins (Xenopus tropicalis)
REACT:R-DRE-2162225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from small HA fragments (Danio rerio)
GO:0103097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP79F1 trihomomethionine monooxygenase activity
REACT:R-RNO-5633460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds TP53 (Rattus norvegicus)
RHEA:59965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-seryl-[protein]
REACT:R-SCE-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)
RHEA:57554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Rattus norvegicus)
REACT:R-MMU-209891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine is oxidised to noradrenaline (Mus musculus)
RHEA:45997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + a quinone + H2O => a 2-oxocarboxylate + a quinol + NH4(+)
RHEA:68161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-388529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholecystokinin receptors bind cholecystokinin (Mus musculus)
REACT:R-SPO-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Schizosaccharomyces pombe)
RHEA:69209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate
RHEA:49734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + violacein => H(+) + O2 + violaceinate
GO:0050445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity
GO:0050445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagusic dehydrogenase activity
GO:0050445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagusate reductase (NADH2)
GO:0050445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:asparagusate oxidoreductase activity
GO:0050445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagusate dehydrogenase activity
GO:0050445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagusate reductase activity
GO:0050445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagusate reductase (NADH) activity
GO:0050445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2:asparagusate oxidoreductase activity
REACT:R-CFA-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)
EC:2.1.1.316	skos:altLabel	"mitomycin 7-O-methyltransferase"
EC:2.1.1.316	skos:prefLabel	"mitomycin 6-O-methyltransferase"
EC:2.1.1.316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mitomycin 6-O-methyltransferase"
REACT:R-SSC-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)
REACT:R-CFA-8953115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds to MGA:MAX (Canis familiaris)
REACT:R-RNO-159358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A3,4 dimers sulfate DA to DAOS (Rattus norvegicus)
REACT:R-SSC-8956458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNLS:FAD oxidises dh-beta-NAD to NAD+ (Sus scrofa)
REACT:R-BTA-9011984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A is recruited to MYC and BCL2 genes (Bos taurus)
GO:0038058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tumor necrosis factor ligand superfamily member 11 receptor activity
GO:0038058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF11 receptor activity
GO:0038058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANKL receptor activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine-transfer ribonucleate synthetase activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine:tRNATyr ligase (AMP-forming)
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosyl-tRNA synthetase activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine-tRNA ligase activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosyl-transfer RNA synthetase activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosyl-transfer ribonucleic acid synthetase activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine tRNA synthetase activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosyl-transfer ribonucleate synthetase activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine-tRNATyr ligase (AMP-forming)
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine-transfer RNA ligase activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine translase activity
GO:0004831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosyl-tRNA ligase activity
RHEA:21243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-DRE-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
REACT:R-XTR-2395876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
REACT:R-DME-446364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Migfilin interacts with VASP (Drosophila melanogaster)
RHEA:42441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NAD(+) => H(+) + iminosuccinate + NADH
REACT:R-SCE-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Saccharomyces cerevisiae)
RHEA:56899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + ATP + H(+) <=> an acyl-AMP + diphosphate
REACT:R-BTA-1433451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds to p-KIT (Bos taurus)
REACT:R-SSC-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Sus scrofa)
RHEA:19529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovitexin + UDP-alpha-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP
RHEA:19529	skos:prefLabel	"isovitexin beta-glucosyltransferase"
RHEA:19529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isovitexin beta-glucosyltransferase"
REACT:R-GGA-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Gallus gallus)
REACT:R-RNO-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Rattus norvegicus)
REACT:R-SPO-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Schizosaccharomyces pombe)
REACT:R-BTA-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Bos taurus)
REACT:R-XTR-5692770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Xenopus tropicalis)
REACT:R-DME-204850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Dok-2 (Drosophila melanogaster)
REACT:R-HSA-9636457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SapM dephosphorylates PI3P (Homo sapiens)
REACT:R-BTA-9710263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GZMB cleaves GSDME (Bos taurus)
GO:0001096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIF-class transcription factor complex binding
GO:0001096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIF-class transcription factor binding
RHEA:14883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagusate + H(+) + NADH => 3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+)
RHEA:57677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] => 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:52625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate
REACT:R-DRE-374298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid receptors bind opioid peptides (Danio rerio)
REACT:R-GGA-9710354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds cardiolipin (Gallus gallus)
RHEA:24548	skos:altLabel	"epsilon-lysine acylase"
RHEA:24548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-acyl-L-lysine + H2O = a carboxylate + L-lysine
RHEA:24548	skos:prefLabel	"acyl-lysine deacylase"
RHEA:24548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lysine deacylase"
REACT:R-MMU-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Mus musculus)
RHEA:18038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O => N-carbamoylputrescine + NH4(+)
REACT:R-XTR-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)
REACT:R-CFA-6788582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 phosphorylation (Canis familiaris)
REACT:R-BTA-114352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of tBID by BCL-2 (Bos taurus)
REACT:R-DME-8849085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RHOA:GTP (Drosophila melanogaster)
RHEA:39314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)
RHEA:26528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA
RHEA:50380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 malonyl-CoA = 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA
RHEA:50380	skos:prefLabel	"phloroglucinol synthase"
RHEA:50380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phloroglucinol synthase"
REACT:R-SPO-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Schizosaccharomyces pombe)
RHEA:23991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate
GO:0001065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial single subunit type RNA polymerase activity
REACT:R-MMU-977619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Mus musculus)
RHEA:58585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate => (-)-tabersonine + acetate + H(+)
RHEA:56211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)
RHEA:29313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + glyoxylate + 2 H(+) + H2O + sulfite => FMNH2 + O2 + sulfoacetate
RHEA:41099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
GO:0003937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP 1,2-hydrolase (decyclizing)
GO:0003937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosinate cyclohydrolase activity
GO:0003937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosinicase activity
GO:0003937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP cyclohydrolase activity
GO:0003937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP synthetase activity
RHEA:21770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methylamine + NADPH + pyruvate => H2O + N-methyl-L-alanine + NADP(+)
REACT:R-DME-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Drosophila melanogaster)
REACT:R-XTR-9667965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds PP2A (Xenopus tropicalis)
REACT:R-HSA-9653585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Farn-Me KRAS4B binds calmodulin (Homo sapiens)
REACT:R-MMU-109860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 phosphorylates MAPK3 (Mus musculus)
RHEA:54456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
REACT:R-RNO-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Rattus norvegicus)
RHEA:52908	skos:prefLabel	"4-hydroxy-3-prenylphenylpyruvate oxygenase"
RHEA:52908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-3-prenylphenylpyruvate oxygenase"
RHEA:52908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dimethylallyl-4-hydroxyphenylpyruvate + O2 = 3-dimethylallyl-4-hydroxymandelate + CO2
REACT:R-XTR-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Xenopus tropicalis)
GO:0102229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amylopectin maltohydrolase activity
REACT:R-MMU-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
RHEA:23480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylene-3-methylsuccinate = dimethylmaleate
RHEA:23480	skos:prefLabel	"methylitaconate Delta-isomerase"
RHEA:23480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylitaconate Delta-isomerase"
RHEA:24983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methylanthranilate + ATP + H(+) <=> 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate
REACT:R-XTR-5656070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFBPs bind FGFs (Xenopus tropicalis)
REACT:R-CFA-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Canis familiaris)
REACT:R-MMU-204947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF migrates to the nucleus (Mus musculus)
RHEA:54396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
REACT:R-RNO-2993780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO1 from E1 to UBE2I (UBC9) (Rattus norvegicus)
RHEA:58534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	akuammicine + formate + H(+) => 15alpha-stemmadenine intermediate I + H2O
GO:0045237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR1 chemokine receptor binding
GO:0045237	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CXCR1 chemokine receptor ligand
REACT:R-GGA-391157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds SKAP2 (Gallus gallus)
RHEA:16651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Xenopus tropicalis)
RHEA:57964	skos:altLabel	"CYP71BL1"
RHEA:57964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57964	skos:prefLabel	"germacreene A acid 8beta-hydroxylase"
RHEA:57964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"germacreene A acid 8beta-hydroxylase"
RHEA:57964	skos:altLabel	"CYP71BL6"
RHEA:72183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine(in) + H(+)(out) = creatinine(out) + H(+)(in)
REACT:R-HSA-8851919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 and GRB2 (Homo sapiens)
RHEA:62782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2
GO:0016711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonoid 3-monooxygenase
GO:0016711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonoid 3-hydroxylase
GO:0016711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonoid 3'-hydroxylase activity
GO:0016711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)
GO:0016711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonoid 3'-monooxygenase activity
GO:0016711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:flavonoid-3'-hydroxylase activity
RHEA:25240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CDP <=> ADP + CTP
GO:0047187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase"
GO:0047187	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity
GO:0047187	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity
GO:0047187	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity
GO:0047187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity
GO:0047187	skos:prefLabel	"deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase"
GO:0047187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[citrate lyase ACP] + S-acetylphosphopantotheine = (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]
GO:0047187	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity
EC:3.4.17.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxypeptidase U"
EC:3.4.17.20	skos:altLabel	"carboxypeptidase R"
EC:3.4.17.20	skos:altLabel	"TAFI"
EC:3.4.17.20	skos:altLabel	"arginine carboxypeptidase"
EC:3.4.17.20	skos:altLabel	"thrombin-activatable fibrinolysis inhibitor"
EC:3.4.17.20	skos:prefLabel	"carboxypeptidase U"
EC:3.4.17.20	skos:altLabel	"carboxypeptidase B2"
EC:3.4.17.20	skos:altLabel	"plasma carboxypeptidase B"
RHEA:31178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-methylpropenoyl-CoA + H2O <=> (S)-3-hydroxyisobutanoyl-CoA
RHEA:19151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NAD(+)
GO:0004705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JUN kinase activity
GO:0004705	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SAPK1
GO:0004705	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	c-Jun N-terminal kinase activity
GO:0004705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JNK
GO:0004705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	JNK3alpha1
RHEA:12883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+) => ADP-alpha-D-glucose + sn-glycerol 3-phosphate
RHEA:18831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)
REACT:R-MMU-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Mus musculus)
REACT:R-DME-9634861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT2 (Drosophila melanogaster)
REACT:R-CFA-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Canis familiaris)
REACT:R-CFA-2022396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-43) (Canis familiaris)
REACT:R-GGA-1008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 leaves endosome membrane (Gallus gallus)
REACT:R-SSC-6803789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Sus scrofa)
GO:0140659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal motor regulator activity
GO:0140659	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	motor activity regulator activity
RHEA:69672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin 7-O-beta-D-glucoside + H2O => (2S)-naringenin + beta-D-glucose
REACT:R-HSA-6798126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates CASP6 expression (Homo sapiens)
REACT:R-RNO-1236941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of receptor bound antigen into clathrin coted vesicles (Rattus norvegicus)
RHEA:36964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA
GO:0035663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR2 binding
GO:0035663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Toll-like receptor 2 binding
RHEA:56469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O
RHEA:51705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthohumol => 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-445071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reinsertion of L1 into the plasma membrane (Mus musculus)
RHEA:10472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate
RHEA:10472	skos:prefLabel	"2,3-dimethylmalate lyase"
RHEA:10472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-dimethylmalate lyase"
RHEA:10472	skos:altLabel	"(2R,3S)-2,3-dimethylmalate pyruvate-lyase"
REACT:R-DME-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Drosophila melanogaster)
REACT:R-HSA-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Homo sapiens)
GO:0102358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daphnetin-8-O-methyltransferase activity
REACT:R-CEL-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Caenorhabditis elegans)
REACT:R-HSA-5618093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP90 (Homo sapiens)
REACT:R-XTR-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Xenopus tropicalis)
REACT:R-GGA-879221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSTPIP1 binds Pyrin (Gallus gallus)
EC:3.4.24.27	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thermolysin"
EC:3.4.24.27	skos:altLabel	"Bacillus thermoproteolyticus neutral proteinase"
EC:3.4.24.27	skos:prefLabel	"thermolysin"
REACT:R-RNO-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Rattus norvegicus)
RHEA:43549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
RHEA:68550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol => O2 + psoralen + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-9708457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HM13 cleaves HMOX1 dimer (Xenopus tropicalis)
RHEA:10419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + toluene <=> 2-benzylsuccinate
REACT:R-DRE-73598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Danio rerio)
RHEA:72931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] = atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-8873929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates STARD10 (Mus musculus)
REACT:R-RNO-1306953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)
RHEA:58881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-MMU-211983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2J2 oxidises ARA (Mus musculus)
REACT:R-DRE-994140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Danio rerio)
RHEA:40862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-hexadecadienoyl-CoA + FADH2
RHEA:22620	skos:altLabel	"tryptophan side-chain oxidase"
RHEA:22620	skos:altLabel	"TSO"
RHEA:22620	skos:prefLabel	"tryptophan 2'-dioxygenase"
RHEA:22620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan 2'-dioxygenase"
RHEA:22620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH4(+)
RHEA:22620	skos:altLabel	"tryptophan side-chain alpha,beta-oxidase"
RHEA:22620	skos:altLabel	"indole-3-alkane alpha-hydroxylase"
REACT:R-HSA-6806419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the FANCC gene (Homo sapiens)
REACT:R-BTA-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Bos taurus)
REACT:R-MMU-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)
REACT:R-SSC-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Sus scrofa)
REACT:R-BTA-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Bos taurus)
REACT:R-CFA-189398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
REACT:R-HSA-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Homo sapiens)
RHEA:35186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxythiophene-2-carbonyl-CoA + H2O <=> 4-carboxy-2-thioxobutanoyl-CoA
RHEA:69578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+)
REACT:R-XTR-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Xenopus tropicalis)
REACT:R-HSA-444620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide S receptor binds neuropeptide S (Homo sapiens)
REACT:R-DDI-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Dictyostelium discoideum)
REACT:R-RNO-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Rattus norvegicus)
REACT:R-SCE-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Saccharomyces cerevisiae)
REACT:R-MMU-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Mus musculus)
RHEA:58071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + trans-isoeugenol <=> acetaldehyde + vanillin
RHEA:70915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(in) + H(+)(in) = guanosine(out) + H(+)(out)
REACT:R-DRE-8855648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM3 binds LAR-RPTP (Danio rerio)
REACT:R-HSA-2161795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Homo sapiens)
RHEA:57656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1balpha + H(+)
REACT:R-MMU-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Mus musculus)
REACT:R-BTA-192123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates CHOL (Bos taurus)
RHEA:64803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + S-(2-aminoethyl)-L-cysteine <=> (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)
GO:0031867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP4 subtype prostaglandin E2 receptor binding
GO:0031867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostanoid EP4 receptor binding
GO:0031867	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	EP4 subtype prostaglandin E2 receptor ligand
RHEA:55199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanoyl-CoA <=> formyl-CoA + heptadecanal
GO:0043716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity
GO:0043716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity
GO:0043716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK-MTPenyl-1-P phosphatase activity
RHEA:40873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-octadecadienoyl-CoA + FADH2 => (9Z)-octadecenoyl-CoA + FAD + H(+)
RHEA:66083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate
REACT:R-BTA-2327738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Bos taurus)
RHEA:60522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glycine + L-cystine => 2 H2O + L-cystine-bis-glycine
REACT:R-RNO-8865613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Rattus norvegicus)
REACT:R-HSA-205056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDM4 inhibits cyclin E transcription (Homo sapiens)
REACT:R-HSA-5691411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)
RHEA:56511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP
RHEA:52256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine
GO:0102509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3,5-diglucoside glucosidase activity
REACT:R-SCE-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Saccharomyces cerevisiae)
REACT:R-SCE-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Saccharomyces cerevisiae)
RHEA:51698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + xanthohumol => desmethylxanthohumol + S-adenosyl-L-methionine
RHEA:10129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin => all-trans-neoxanthin
GO:0052909	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	M(6)(2)A dimethylase activity
GO:0052909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
GO:0033907	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-fucoside fucohydrolase activity
GO:0033907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fucosidase activity
GO:0033907	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-fucosidase activity
RHEA:22012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"precorrin-4 C(11)-methyltransferase"
RHEA:22012	skos:altLabel	"precorrin-3 methylase"
RHEA:22012	skos:altLabel	"precorrin-4 C11-methyltransferase"
RHEA:22012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-4 + S-adenosyl-L-methionine = precorrin-5 + S-adenosyl-L-homocysteine
RHEA:22012	skos:prefLabel	"precorrin-4 C(11)-methyltransferase"
REACT:R-MMU-166721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Mus musculus)
RHEA:10300	skos:altLabel	"triosephosphate dehydrogenase"
RHEA:10300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH
RHEA:10300	skos:prefLabel	"glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)"
RHEA:10300	skos:altLabel	"GAPDH"
RHEA:10300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)"
RHEA:10300	skos:altLabel	"NAD-dependent glyceraldehyde-3-phosphate dehydrogenase"
RHEA:69868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in RNA + S-adenosyl-L-methionine => a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine
RHEA:15036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pyridoxine <=> H2O2 + pyridoxal
REACT:R-MMU-114354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP:Caspase-7 (Mus musculus)
RHEA:59382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH => 4-amino-4-deoxyprephenate + NAD(+)
RHEA:48511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NADP(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH
REACT:R-HSA-3249371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylates STAT6 at Ser407 (Homo sapiens)
RHEA:22240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylenediurea = N-(carboxyaminomethyl)urea + NH4(+)
GO:0043884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACS
GO:0043884	skos:prefLabel	"CO-methylating acetyl-CoA synthase"
GO:0043884	skos:altLabel	"ACS"
GO:0043884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO-methylating acetyl-coenzyme A synthase activity
GO:0043884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA:corrinoid protein O-acetyltransferase activity
GO:0043884	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetyl-CoA synthase activity
GO:0043884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) = CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]
GO:0043884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CO-methylating acetyl-CoA synthase"
GO:0043884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO-methylating acetyl-CoA synthase activity
REACT:R-DRE-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Danio rerio)
REACT:R-HSA-3322434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP dissociates from ub-TLE (Homo sapiens)
RHEA:27432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1,2-diacyl-sn-glycerol + phosphate
REACT:R-RNO-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Rattus norvegicus)
REACT:R-HSA-9005995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the SIN3A co-repressor complex (Homo sapiens)
REACT:R-HSA-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)
RHEA:55361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol => 9-cis-retinol
REACT:R-SSC-5675947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF18 binds TNFRSF18 (Sus scrofa)
REACT:R-XTR-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Xenopus tropicalis)
RHEA:34630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]
RHEA:69652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cumene hydroperoxide + 2 glutathione => 2-phenylpropan-2-ol + glutathione disulfide + H2O
REACT:R-HSA-9700656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alectinib resistant ALK mutants don't bind alectinib (Homo sapiens)
REACT:R-GGA-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Gallus gallus)
GO:0016740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Homo sapiens)
GO:0016740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity
REACT:R-MMU-9639287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2 binds L-leucine and dissociates from GATOR2 (Mus musculus)
RHEA:35316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA + CO2 + CoA
RHEA:61229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidine + O2 => 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)
REACT:R-HSA-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Homo sapiens)
REACT:R-RNO-5654647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
RHEA:45278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxy-(9E)-octadecenoate + phosphate => 12-phosphooxy-(9E)-octadecenoate + H2O
GO:0050001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutaminase activity
GO:0050001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamine amidohydrolase activity
RHEA:52835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
REACT:R-HSA-9031575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-1 binds ARC gene (Homo sapiens)
GO:0102730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cathasterone hydroxylase activity
RHEA:23661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propanoate + H2O => N-formimidoyl-L-glutamate
EC:3.4.21.4	skos:prefLabel	"trypsin"
EC:3.4.21.4	skos:altLabel	"beta-trypsin"
EC:3.4.21.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trypsin"
EC:3.4.21.4	skos:altLabel	"alpha-trypsin"
REACT:R-CFA-2031355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
REACT:R-CFA-879914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3 stimulation induces Vav binding to Tec kinase (Canis familiaris)
REACT:R-DDI-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:67454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+) => a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O
REACT:R-RNO-5623513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 stimulates GTPase activity of ARF4 (Rattus norvegicus)
RHEA:58919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene <=> (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-SPO-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Schizosaccharomyces pombe)
RHEA:34261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-3'-hydroxylarreatricin + A + H2O => (+)-larreatricin + AH2 + O2
RHEA:45878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA => 2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA
REACT:R-DRE-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Danio rerio)
RHEA:63081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + ilicicolinate B => A + AMP + diphosphate + ilicicolin B
REACT:R-CFA-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Canis familiaris)
REACT:R-DRE-8876312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Danio rerio)
RHEA:64144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-methionine = (9Z)-octadecenoate + L-methionine
RHEA:33248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + putrescine => 1-pyrroline + H2O2 + NH4(+)
RHEA:33321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA
RHEA:13185	skos:altLabel	"HMB-synthase"
RHEA:13185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxymethylbilane synthase"
RHEA:13185	skos:altLabel	"(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolyzing)"
RHEA:13185	skos:altLabel	"porphobilinogen deaminase"
RHEA:13185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)
RHEA:13185	skos:prefLabel	"hydroxymethylbilane synthase"
RHEA:13185	skos:altLabel	"uroporphyrinogen synthase"
RHEA:13185	skos:altLabel	"uroporphyrinogen synthetase"
RHEA:13185	skos:altLabel	"pre-uroporphyrinogen synthase"
RHEA:13185	skos:altLabel	"uroporphyrinogen I synthase"
RHEA:13185	skos:altLabel	"uroporphyrinogen I synthetase"
RHEA:55696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O = an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate
GO:0032067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type IV restriction enzyme activity
GO:0032067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type IV site-specific deoxyribonuclease activity
REACT:R-HSA-5626220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 binds the mother centriole (Homo sapiens)
REACT:R-MMU-5654510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 binds SPRED1/2 (Mus musculus)
REACT:R-DME-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-HSA-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Homo sapiens)
REACT:R-BTA-2730876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IKK-beta by TAK1 (Bos taurus)
GO:0106063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled folic acid receptor activity
GO:0106063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled folate receptor activity
GO:0106063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled folate receptor activity
REACT:R-CFA-211881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A13 (Canis familiaris)
REACT:R-DDI-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Dictyostelium discoideum)
REACT:R-SCE-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Saccharomyces cerevisiae)
RHEA:49476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-1-piperideine-6-carboxylate + NAD(+) = H(+) + L-2-aminoadipate + NADH
REACT:R-CEL-2168886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemopexin binds Hemes (Caenorhabditis elegans)
REACT:R-RNO-3296326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR1 binds LACT (Rattus norvegicus)
REACT:R-BTA-159194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Bos taurus)
REACT:R-MMU-351936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of claspin (Mus musculus)
REACT:R-MMU-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Mus musculus)
RHEA:46472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-XTR-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Xenopus tropicalis)
GO:0070628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteasome binding
REACT:R-HSA-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Homo sapiens)
REACT:R-DRE-2076383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3ST1 sulfates GlcN at C3 in heparan sulfate (Danio rerio)
RHEA:31419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = (-)-beta-curcumene + diphosphate
REACT:R-GGA-8853444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PHLDA1 (Gallus gallus)
REACT:R-DRE-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Danio rerio)
RHEA:21646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + sn-glycerol 3-phosphate => ATP + glycerol
REACT:R-HSA-110158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG glycosylase mediated recognition and binding of a thymine opposite to a guanine (Homo sapiens)
RHEA:15492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H2O + 2 O2 <=> 9-riburonosyladenine + H(+) + 2 H2O2
RHEA:56887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:32106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine
REACT:R-HSA-918224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX58 is K63 polyubiquitinated (Homo sapiens)
REACT:R-BTA-1475022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)
REACT:R-HSA-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Homo sapiens)
REACT:R-HSA-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)
RHEA:35970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:30372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O => (-)-geosmin + acetone
RHEA:70657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + sarcosine(out) => H(+)(in) + sarcosine(in)
REACT:R-DRE-9654525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Danio rerio)
RHEA:64376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2
REACT:R-DRE-380927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK phosphorylates TSC1:TSC2 (Danio rerio)
REACT:R-MMU-8852280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds microtubule lattice in interphase cells (Mus musculus)
RHEA:46283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-174427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Mus musculus)
REACT:R-CEL-5688834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds VCP (Caenorhabditis elegans)
REACT:R-DDI-6782820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates SUDS3 (Dictyostelium discoideum)
REACT:R-DME-209221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)
RHEA:69385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) => (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]
REACT:R-HSA-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Homo sapiens)
REACT:R-GGA-4341016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Gallus gallus)
REACT:R-SSC-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Sus scrofa)
RHEA:51683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + CTP <=> (2E,6E)-farnesyl phosphate + CDP + H(+)
REACT:R-MMU-9638076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from small HA fragments (Mus musculus)
RHEA:71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + malonate(out) => 2-oxoglutarate(out) + malonate(in)
RHEA:20425	skos:altLabel	"oxalosuccinate synthetase"
RHEA:20425	skos:altLabel	"CFI"
RHEA:20425	skos:altLabel	"OGC"
RHEA:20425	skos:prefLabel	"2-oxoglutarate carboxylase"
RHEA:20425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoglutarate carboxylase"
RHEA:20425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + ATP + hydrogencarbonate = (S)-oxalosuccinate + ADP + H(+) + phosphate
RHEA:20425	skos:altLabel	"carboxylating factor for ICDH"
RHEA:59038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-DRE-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Danio rerio)
RHEA:53477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-SSC-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Sus scrofa)
RHEA:54179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + holo-[ACP] + NADP(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADPH
REACT:R-GGA-209566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is auto-ubiquitinated (Gallus gallus)
RHEA:72357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(in) + glutarate(out) => dehydroepiandrosterone 3-sulfate(out) + glutarate(in)
RHEA:31491	skos:prefLabel	"soyasaponin III rhamnosyltransferase"
RHEA:31491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasaponin III + UDP-beta-L-rhamnose = H(+) + soyasaponin I + UDP
RHEA:31491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"soyasaponin III rhamnosyltransferase"
RHEA:35830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-aminopropylagmatine <=> spermidine + urea
REACT:R-DRE-2161187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)
REACT:R-CFA-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)
REACT:R-RNO-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)
REACT:R-DRE-5696482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTF1 binds LIFR:JAKs (Danio rerio)
RHEA:28196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfopyruvate + H(+) + NADH => (2S)-3-sulfolactate + NAD(+)
RHEA:63578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone + phosphate => ecdysone 22-phosphate + H2O
REACT:R-CFA-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Canis familiaris)
RHEA:53208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaose + O2 = D-maltopentaono-1,5-lactone + H2O2
RHEA:40760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate
RHEA:36066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + kunzeaol
RHEA:54862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+) => (2E)-geranial + H(+) + NADPH + O2
REACT:R-DDI-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Dictyostelium discoideum)
RHEA:35908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-XTR-1236398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds NRGs or EGF-like ligands (Xenopus tropicalis)
REACT:R-DRE-5226904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Danio rerio)
REACT:R-DRE-5683735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 is recruited to DNA DSBs (Danio rerio)
REACT:R-XTR-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Xenopus tropicalis)
RHEA:44020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate
REACT:R-RNO-9624017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SHC1 binds integrin alpha5beta1:fibronectin (Rattus norvegicus)
RHEA:47011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite
REACT:R-SSC-5218809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Sus scrofa)
RHEA:51300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-phenylalanine = H2O + N-(9Z-octadecenoyl)-L-phenylalanine
REACT:R-PFA-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Plasmodium falciparum)
RHEA:51980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-N,N-dihydroxypolyhomomethionine + H(+) = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O
RHEA:71931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(out) + 3 Na(+)(out) = fumarate(in) + 3 Na(+)(in)
REACT:R-HSA-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)
REACT:R-SPO-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Schizosaccharomyces pombe)
RHEA:49990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl acetate + NADP(+) => acetone + H(+) + NADPH + O2
RHEA:71048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + L-phenylalanine(out) => glycine(out) + L-phenylalanine(in)
RHEA:54293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate
RHEA:34035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + paromamine = 6'-oxoparomamine + H2O2
RHEA:34035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"paromamine 6'-oxidase"
RHEA:34035	skos:prefLabel	"paromamine 6'-oxidase"
REACT:R-SSC-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Sus scrofa)
GO:0022850	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serotonin-gated cation channel activity
GO:0022850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serotonin-gated cation-selective channel activity
GO:0022850	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	5-hydroxytryptamine-gated receptor-channel
GO:0022850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serotonin-activated cation-selective channel activity
RHEA:49210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-GGA-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Gallus gallus)
REACT:R-HSA-2160906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20kDa HA fragments are translocated to lysosomes (Homo sapiens)
RHEA:18416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:46234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-HSA-2993447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6x(PCCA:PCCB) (Homo sapiens)
REACT:R-RNO-6785178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Rattus norvegicus)
REACT:R-CFA-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Canis familiaris)
RHEA:13060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylneuraminate 9-phosphate + H2O <=> an N-acylneuraminate + phosphate
RHEA:15212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH
RHEA:34120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA
RHEA:37610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-BTA-450466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1:mRNA complex is destroyed (Bos taurus)
RHEA:40552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylphylloquinol + S-adenosyl-L-methionine => H(+) + phylloquinol + S-adenosyl-L-homocysteine
REACT:R-SSC-5683077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate KDM4A,B (Sus scrofa)
GO:0033954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-neoagarooligosaccharide hydrolase activity
GO:0033954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-neoagaro-oligosaccharide 3-glycohydrolase activity
GO:0033954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-NAOS hydrolase activity
GO:0033954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-neoagaro-oligosaccharide hydrolase activity
REACT:R-HSA-5682709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI4 binds ADAM22,23,11 (Homo sapiens)
REACT:R-DRE-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Danio rerio)
REACT:R-RNO-975903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Rattus norvegicus)
RHEA:47795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SPO-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Schizosaccharomyces pombe)
REACT:R-RNO-9629216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Rattus norvegicus)
REACT:R-GGA-8987156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Gallus gallus)
REACT:R-CFA-8944263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type II (Canis familiaris)
REACT:R-GGA-8982645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRKs bind ADRB2:Catecholamine (Gallus gallus)
GO:0031696	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-2C adrenergic receptor ligand
GO:0031696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2C adrenergic receptor binding
RHEA:64139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-asparagine <=> (9Z)-octadecenoate + L-asparagine
REACT:R-XTR-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Xenopus tropicalis)
REACT:R-HSA-8956568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the core TAL1 complex (Homo sapiens)
RHEA:44978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-propanoyl-(R)-carnitine => (R)-carnitine + propanoyl-CoA
REACT:R-GGA-429767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Gallus gallus)
RHEA:25301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H2O + NADP(+) <=> acetate + 2 H(+) + NADPH
GO:0047256	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactosylceramide beta-acetylglucosaminyltransferase activity
GO:0047256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity
GO:0047256	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LA2 synthase activity
GO:0047256	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity
GO:0047256	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta1->3-N-acetylglucosaminyltransferase activity
GO:0047256	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity
REACT:R-RNO-8865637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFSD2A transports LPC from extracellular region to plasma membrane (Rattus norvegicus)
REACT:R-SSC-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Sus scrofa)
RHEA:30870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-acetaldehyde + NAD(+) <=> (indol-3-yl)acetate + 2 H(+) + NADH
REACT:R-BTA-983707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates at the activated BCR (Bos taurus)
RHEA:31492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasaponin III + UDP-beta-L-rhamnose => H(+) + soyasaponin I + UDP
REACT:R-SSC-5685366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y-SHC (Sus scrofa)
RHEA:60100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin + UDP-alpha-D-glucose = cyanidin 3-O-beta-D-glucoside + H(+) + UDP
RHEA:45425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-GGA-2267372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Gallus gallus)
RHEA:31748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH
REACT:R-MMU-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Mus musculus)
RHEA:60425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => diphosphate + valerianol
RHEA:68557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
REACT:R-DME-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Drosophila melanogaster)
RHEA:45655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-HSA-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Homo sapiens)
RHEA:36753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose
REACT:R-BTA-1504193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL is degraded by the proteasome (Bos taurus)
GO:0047560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KTS reductase activity
GO:0047560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-oxosphinganine reductase activity
GO:0047560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketosphinganine reductase activity
GO:0047560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-oxosphinganine:B-NADPH oxidoreductase activity
GO:0047560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxosphinganine reductase activity
GO:0047560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DSR activity
GO:0047560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxosphinganine:NADPH oxidoreductase activity
GO:0047560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-dehydrosphinganine reductase activity
GO:0047560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity
GO:0047560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrosphinganine reductase activity
REACT:R-RNO-389756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT interacts and phosphorylates Cot (Rattus norvegicus)
RHEA:48903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:60507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)
RHEA:31346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate
RHEA:12874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoate + NADP(+) => 4-methyl-2-oxopentanoate + H(+) + NADPH
REACT:R-DRE-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)
RHEA:11373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + NH4(+) => AMP + diphosphate + H(+) + L-asparagine
REACT:R-XTR-994140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Xenopus tropicalis)
RHEA:60171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP <=> a fatty acyl monophosphate + ADP
RHEA:38506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)
RHEA:37184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-SCE-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Saccharomyces cerevisiae)
REACT:R-HSA-2467665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds Beta amyloid fibril via GAG chains (Homo sapiens)
REACT:R-SSC-2024084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS-GAGs translocate to the lysosome for degradation (Sus scrofa)
RHEA:20163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + raffinose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose
RHEA:48124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate
RHEA:20707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + acetyl-CoA <=> an N-acetyl-D-amino acid + CoA + H(+)
REACT:R-DRE-1564142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV degradation by MMP2,3,4,9,10,12 (Danio rerio)
REACT:R-XTR-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-CFA-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Canis familiaris)
EC:2.4.1.44	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipopolysaccharide 3-alpha-galactosyltransferase"
EC:2.4.1.44	skos:altLabel	"uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase"
EC:2.4.1.44	skos:altLabel	"uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase"
EC:2.4.1.44	skos:altLabel	"lipopolysaccharide 1,3-galactosyltransferase"
EC:2.4.1.44	skos:altLabel	"UDP-galactose:polysaccharide galactosyltransferase"
EC:2.4.1.44	skos:altLabel	"UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase"
EC:2.4.1.44	skos:prefLabel	"lipopolysaccharide 3-alpha-galactosyltransferase"
EC:2.4.1.44	skos:altLabel	"lipopolysaccharide galactosyltransferase"
RHEA:39906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)
RHEA:47434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
GO:0034948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypseudooxynicotine hydrolase activity
REACT:R-GGA-5693564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with RAD52:DNA double-strand break ends (Gallus gallus)
RHEA:36927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA
GO:1901584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrapeptide transmembrane transporter activity
RHEA:62358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GMP + H(+) + phosphate => 8-oxo-GDP + H2O
REACT:R-CFA-114577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Canis familiaris)
REACT:R-DRE-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)
RHEA:11828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)
RHEA:11828	skos:prefLabel	"RNA 2',3'-cyclic 3'-phosphodiesterase"
RHEA:11828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RNA 2',3'-cyclic 3'-phosphodiesterase"
RHEA:45418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+) => 11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O
GO:0047343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-glucose diphosphorylase activity
GO:0047343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP glucose pyrophosphorylase activity
GO:0047343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoglucose pyrophosphorylase activity
GO:0047343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity
GO:0047343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:D-glucose-1-phosphate cytidylyltransferase activity
GO:0047343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:glucose-1-phosphate cytidylyltransferase activity
GO:0047343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphate glucose pyrophosphorylase activity
GO:0047343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphate-D-glucose pyrophosphorylase activity
GO:0047343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-1-phosphate cytidylyltransferase activity
GO:0047343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-glucose pyrophosphorylase activity
RHEA:33670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)
GO:0050113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-inositol oxygenase activity
GO:0050113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MOO activity
GO:0050113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol oxygenase activity
GO:0050113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol:oxygen oxidoreductase activity
GO:0050113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol oxygenase activity
RHEA:50530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein]
REACT:R-HSA-9010681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates ROBO3.1 (Homo sapiens)
REACT:R-DME-428518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glypican-1 (GPC1) binds SLIT2 (Drosophila melanogaster)
RHEA:52012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
RHEA:67726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP(in) + CMP-N-acetyl-beta-neuraminate(out) => CMP(out) + CMP-N-acetyl-beta-neuraminate(in)
REACT:R-XTR-5625796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM4C binds KLK2 and KLK3 promoters (Xenopus tropicalis)
REACT:R-XTR-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)
REACT:R-BTA-1297333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Acrosin Heavy and Light Chain (Bos taurus)
REACT:R-HSA-8939829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGBL1 gene expression is stimulated by RUNX2 (Homo sapiens)
EC:3.2.2.21	skos:altLabel	"DNA glycosidase II"
EC:3.2.2.21	skos:prefLabel	"DNA-3-methyladenine glycosylase II"
EC:3.2.2.21	skos:altLabel	"DNA-3-methyladenine glycosidase II"
EC:3.2.2.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA-3-methyladenine glycosylase II"
REACT:R-CFA-192054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Canis familiaris)
RHEA:72020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + O2 + trihazone A => 2 CO2 + H2O + succinate + trihazone D
RHEA:35560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinone-7 + NADH => menaquinol-7 + NAD(+)
RHEA:64831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + acetyl-CoA <=> 3-hydroxy-benzyl acetate + CoA
REACT:R-HSA-450827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Homo sapiens)
REACT:R-HSA-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Homo sapiens)
REACT:R-DME-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Drosophila melanogaster)
GO:0045353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1 type II receptor antagonist activity
GO:0045353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-1ra type II
REACT:R-DRE-109998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Danio rerio)
RHEA:47030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-disulfide + H(+) + sulfite => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine
RHEA:36144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + H(+) + NADPH => hexadecanoyl-CoA + NADP(+)
RHEA:14307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-prolyl-tRNA(Pro) => ATP + L-proline + tRNA(Pro)
REACT:R-BTA-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Bos taurus)
RHEA:67304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = H2O2 + myceliothermophin E
REACT:R-RNO-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Rattus norvegicus)
GO:0015462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein ABC transporter
GO:0015462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type protein transmembrane transporter activity
GO:0015462	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein-transporting ATPase activity
GO:0015462	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pilin/fimbrilin exporter activity
GO:0015462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type protein transporter activity
GO:0015462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-transmembrane transporting ATPase activity
GO:0015462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled protein transmembrane transporter activity
RHEA:71917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + tauronorcholate(in) => 2 Na(+)(out) + tauronorcholate(out)
REACT:R-MMU-5682983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates WHSC1 (Mus musculus)
REACT:R-HSA-751001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (i) reassociates with G beta:gamma (Homo sapiens)
REACT:R-RNO-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Rattus norvegicus)
REACT:R-DRE-6799199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Danio rerio)
REACT:R-MMU-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Mus musculus)
REACT:R-HSA-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Homo sapiens)
REACT:R-CEL-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)
EC:6.2.1.45	skos:prefLabel	"E1 ubiquitin-activating enzyme"
EC:6.2.1.45	skos:altLabel	"ubiquitin-activating enzyme E1"
EC:6.2.1.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"E1 ubiquitin-activating enzyme"
RHEA:28323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + wogonin => UDP + wogonin 7-O-beta-D-glucuronate
RHEA:53760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholate + deoxycholoyl-CoA = allocholoyl-CoA + deoxycholate
REACT:R-DDI-77590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CstF to the CPSF Bound Pre-mRNA (Dictyostelium discoideum)
RHEA:35847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + sphing-4-enine = ADP + H(+) + sphing-4-enine 1-phosphate
REACT:R-CEL-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Caenorhabditis elegans)
REACT:R-SSC-8849055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARHGAP35 (Sus scrofa)
RHEA:38332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol
RHEA:16946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)
REACT:R-DRE-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Danio rerio)
REACT:R-RNO-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Rattus norvegicus)
REACT:R-XTR-9686521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2:CCNA phosphorylates TERF2 (Xenopus tropicalis)
REACT:R-DDI-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Dictyostelium discoideum)
REACT:R-SCE-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Saccharomyces cerevisiae)
REACT:R-SSC-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Sus scrofa)
REACT:R-GGA-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Gallus gallus)
GO:0086079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling
RHEA:43076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-4719436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO1 (Bos taurus)
RHEA:59465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octadecan-1-ol => H(+) + NADPH + octadecanal
REACT:R-SSC-8855915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Sus scrofa)
REACT:R-SPO-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Schizosaccharomyces pombe)
REACT:R-DME-170076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Drosophila melanogaster)
REACT:R-SPO-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Schizosaccharomyces pombe)
RHEA:49997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-GGA-1236956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfment of particulate antigen into phagocytic vesicle (Gallus gallus)
RHEA:72358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + glutarate(in) <=> dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
REACT:R-SPO-165182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of complexed TSC2 by PKB (Schizosaccharomyces pombe)
RHEA:52078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-hexadecenoyloxy)-octadecanoate + H2O
REACT:R-SSC-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Sus scrofa)
GO:0045238	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CXCR2 chemokine receptor ligand
GO:0045238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR2 chemokine receptor binding
RHEA:57100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-xylulose 5-phosphate
REACT:R-SSC-389463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteinase-activated receptors can bind thrombin (Sus scrofa)
REACT:R-HSA-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Homo sapiens)
REACT:R-MMU-5654623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS3 (Mus musculus)
GO:0036427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP
GO:0036427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-undecaprenyl-phosphate mannosyltransferase activity
REACT:R-MMU-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Mus musculus)
REACT:R-SSC-9038163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Sus scrofa)
REACT:R-RNO-8858498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SL (surrogate light chain) binds IgH to form pre-BCR (Rattus norvegicus)
RHEA:65341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-threonyl-[protein] => CoA + O-acetyl-L-threonyl-[protein]
GO:0050268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coniferyl-alcohol dehydrogenase"
GO:0050268	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coniferyl-alcohol:NADP+ oxidoreductase activity
GO:0050268	skos:prefLabel	"coniferyl-alcohol dehydrogenase"
GO:0050268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coniferyl-alcohol dehydrogenase activity
RHEA:47322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-3-phenylpropanoate + L-glutamate => (S)-3-amino-3-phenylpropanoate + 2-oxoglutarate
GO:0009922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid elongase activity
GO:0015067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amidinotransferase activity
GO:0015067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transamidinase activity
GO:0015067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Amidinotransferases"
GO:0015067	skos:prefLabel	"Amidinotransferases"
REACT:R-DRE-171059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Danio rerio)
REACT:R-DME-8956639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds YAP1 (Drosophila melanogaster)
REACT:R-HSA-8948228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Homo sapiens)
REACT:R-HSA-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Homo sapiens)
REACT:R-SCE-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Saccharomyces cerevisiae)
REACT:R-CFA-1566962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by elastin-degrading extracellular proteinases (Canis familiaris)
REACT:R-DRE-879584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO3A1 isoform 1 has abroad substrate specificity (Danio rerio)
REACT:R-PFA-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)
REACT:R-SSC-6811423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Sus scrofa)
REACT:R-RNO-2162227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses (HA)2 (Rattus norvegicus)
RHEA:22623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-tryptophan + O2 <=> 3-indoleglycolaldehyde + CO2 + NH4(+)
RHEA:27401	skos:altLabel	"HCCA isomerase"
RHEA:27401	skos:prefLabel	"2-hydroxychromene-2-carboxylate isomerase"
RHEA:27401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate
RHEA:27401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxychromene-2-carboxylate isomerase"
RHEA:27401	skos:altLabel	"2HC2CA isomerase"
REACT:R-DRE-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Danio rerio)
REACT:R-GGA-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Gallus gallus)
RHEA:59914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH => (E)-4-hydroxynon-2-enal + H2O + NADP(+)
REACT:R-DDI-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Dictyostelium discoideum)
REACT:R-BTA-420489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parathyroid hormone receptor can bind parathyroid hormone (Bos taurus)
RHEA:65163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + hexan-2-ol <=> CoA + hexan-2-yl benzoate
REACT:R-SPO-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Schizosaccharomyces pombe)
RHEA:57785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite
REACT:R-SSC-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Sus scrofa)
RHEA:24339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + ATP + CoA <=> AMP + an acyl-CoA + diphosphate
RHEA:43252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate
REACT:R-DDI-389652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Dictyostelium discoideum)
REACT:R-SSC-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Sus scrofa)
REACT:R-HSA-5617879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA4 mRNA is translated (Homo sapiens)
REACT:R-GGA-9710263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GZMB cleaves GSDME (Gallus gallus)
GO:0033981	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity
GO:0033981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-dopachrome decarboxylase activity
GO:0033981	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-dopachrome carboxy-lyase activity
GO:0033981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopachrome decarboxylase activity
GO:0033981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2
GO:0033981	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-tautomerase activity
GO:0033981	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dopachrome conversion activity
GO:0033981	skos:prefLabel	"D-dopachrome decarboxylase"
GO:0033981	skos:altLabel	"D-dopachrome tautomerase"
GO:0033981	skos:altLabel	"D-dopachrome carboxy-lyase"
GO:0033981	skos:altLabel	"D-tautomerase"
GO:0033981	skos:altLabel	"phenylpyruvate tautomerase II"
GO:0033981	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-dopachrome tautomerase activity
GO:0033981	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylpyruvate tautomerase II activity
GO:0033981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-dopachrome decarboxylase"
RHEA:11680	skos:altLabel	"GMP synthetase (glutamine-hydrolyzing)"
RHEA:11680	skos:prefLabel	"GMP synthase (glutamine-hydrolyzing)"
RHEA:11680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GMP synthase (glutamine-hydrolyzing)"
RHEA:11680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate
REACT:R-GGA-392195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi activation by P2Y purinoceptor 12 (Gallus gallus)
RHEA:60468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
RHEA:30970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9',15-tri-cis-zeta-carotene <=> 9,9'-di-cis-zeta-carotene
REACT:R-RNO-193508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)
REACT:R-XTR-1295613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds GRB2 (Xenopus tropicalis)
REACT:R-MMU-2090038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses heparan chain(2) (Mus musculus)
RHEA:47207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)
RHEA:28709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(out) => Cd(2+)(in)
GO:0044388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small protein activating enzyme binding
REACT:R-CFA-6788628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dissociate (Canis familiaris)
RHEA:18419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GM3 (d18:1(4E)) + H(+) => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate
REACT:R-CFA-77584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Canis familiaris)
REACT:R-CFA-5686924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Canis familiaris)
REACT:R-SSC-1605723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Sus scrofa)
REACT:R-DME-350388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROK binds to activated RHO1:GTP (Drosophila melanogaster)
RHEA:42836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-methylnaphthoic acid synthase"
RHEA:42836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH = 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)
RHEA:42836	skos:prefLabel	"5-methylnaphthoic acid synthase"
REACT:R-SSC-6788556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to NDUFV1, V2 (Sus scrofa)
RHEA:71612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + malonate(out) => (S)-malate(out) + malonate(in)
REACT:R-SSC-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Sus scrofa)
REACT:R-RNO-482770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet secretory granule components (Rattus norvegicus)
REACT:R-BTA-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Bos taurus)
REACT:R-GGA-1067640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R-2 (Gallus gallus)
REACT:R-DME-432544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PER transports from the cytosol to the nucleus (Drosophila melanogaster)
REACT:R-CFA-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Canis familiaris)
REACT:R-DRE-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Danio rerio)
REACT:R-DRE-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Danio rerio)
REACT:R-DDI-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Dictyostelium discoideum)
RHEA:11223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine
REACT:R-DRE-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Danio rerio)
RHEA:65141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + protoaustinoid A => A + berkeleyone A + H2O
RHEA:10027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
RHEA:41978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E))
RHEA:41996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP
REACT:R-SCE-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Saccharomyces cerevisiae)
RHEA:34788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH
RHEA:67075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acyl-CoA + H2O <=> a very long-chain fatty acid + CoA + H(+)
GO:0033592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA strand annealing activity
REACT:R-DME-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Drosophila melanogaster)
REACT:R-SCE-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Saccharomyces cerevisiae)
RHEA:57344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-D-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-8943041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Rattus norvegicus)
RHEA:60359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octanoylanthranilate <=> anthranilate + H(+) + octanoate
RHEA:33870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + glyoxylate <=> glycine + N-carbamoyl-2-oxoglycine
REACT:R-SSC-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Sus scrofa)
REACT:R-RNO-169904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3G stimulates nucleotide exchange on Rap1 (Rattus norvegicus)
REACT:R-DDI-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Dictyostelium discoideum)
RHEA:53233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmosterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Rattus norvegicus)
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate, Pi dikinase activity
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-phosphate ligase activity
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-inorganic phosphate dikinase activity
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate, phosphate dikinase activity
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-phosphate dikinase activity
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic-phosphate dikinase activity
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPDK
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate,phosphate dikinase activity
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orthophosphate dikinase pyruvate
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic-phosphate ligase activity
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:pyruvate, phosphate phosphotransferase activity
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-phosphate dikinase (phosphorylating)
GO:0050242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate,orthophosphate dikinase activity
REACT:R-GGA-354073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PTK2 at Y397 (Gallus gallus)
REACT:R-MMU-2730833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TEC kinases by p-SYK (Mus musculus)
RHEA:53840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) = 7,12-dioxo-lithocholate + H(+) + NADPH
RHEA:34709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane => AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine
RHEA:16274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + CDP-choline => a sphingomyelin + CMP + H(+)
REACT:R-BTA-176879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein(a) + LDL => Lp(a) (Bos taurus)
RHEA:11252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydroxylamine + L-asparagine = beta-L-aspartylhydroxamate + NH4(+)
RHEA:11252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartyltransferase"
RHEA:11252	skos:prefLabel	"aspartyltransferase"
GO:0018676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-limonene 7-monooxygenase activity
GO:0018676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-limonene 7-monooxygenase activity
RHEA:25675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
GO:0036082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular phenylacetaldehyde-gated ion channel activity
GO:0036082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ionotropic phenylacetaldehyde receptor activity
RHEA:68604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfopropanediol = H(+) + hydroxyacetone + sulfite
RHEA:68604	skos:prefLabel	"(2S)-3-sulfopropanediol sulfolyase"
RHEA:68604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2S)-3-sulfopropanediol sulfolyase"
RHEA:68604	skos:altLabel	"DHPS sulfolyase"
REACT:R-BTA-6805126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates TP53 (Bos taurus)
EC:7.2.2.-	skos:prefLabel	"Linked to the hydrolysis of a nucleoside triphosphate"
EC:7.2.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Linked to the hydrolysis of a nucleoside triphosphate"
RHEA:50859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
REACT:R-HSA-4332356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK2 binds MAP3K7 (Homo sapiens)
REACT:R-MMU-8933328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYPLA2 hydrolyses PALM-C3,4-GAP43 (Mus musculus)
REACT:R-BTA-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Bos taurus)
RHEA:39176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyeicosanoyl-CoA => (2E)-eicosenoyl-CoA + H2O
RHEA:63935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisate(in) + ATP + H2O <=> abscisate(out) + ADP + H(+) + phosphate
RHEA:51669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone
REACT:R-HSA-9670155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP (Homo sapiens)
RHEA:11467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + L,L-homocystine <=> glutathione disulfide + 2 L-homocysteine
RHEA:45067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoylethanolamine <=> ethanolamine + hexadecanoate
RHEA:66934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenanthramide A + CoA => (E)-4-coumaroyl-CoA + 5-hydroxyanthranilate
RHEA:60469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
REACT:R-MMU-114352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of tBID by BCL-2 (Mus musculus)
RHEA:58568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine + acetyl-CoA = CoA + O-acetyl-15alpha-stemmadenine
RHEA:29194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + menaquinone-8 <=> iminosuccinate + menaquinol-8
REACT:R-RNO-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Rattus norvegicus)
REACT:R-HSA-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Homo sapiens)
RHEA:25685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:70716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) => glycine(out)
REACT:R-HSA-9623096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delayed Early (DE) Gene Expression (Homo sapiens)
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitobiosylpyrophosphoryldolichol synthase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcNAc-1-P transferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosamine-1-phosphate transferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity
GO:0003975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity
RHEA:10596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
EC:5.6.-.-	skos:prefLabel	"Isomerases altering macromolecular conformation"
EC:5.6.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Isomerases altering macromolecular conformation"
GO:0102895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	colneleate synthase activity
REACT:R-XTR-9015111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors binds Xa (Xenopus tropicalis)
REACT:R-RNO-5687101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 phosphorylates FOXO3 (Rattus norvegicus)
GO:0004331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0004331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-2,6-bisphosphate 2-phosphohydrolase activity
GO:0004331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose-2,6-bisphosphatase activity
GO:0004331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity
REACT:R-DRE-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Danio rerio)
GO:0018503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-1,2-dihydrodiolphenanthrene dehydrogenase activity
REACT:R-DDI-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Dictyostelium discoideum)
REACT:R-SSC-176521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Sus scrofa)
RHEA:64464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[protein] + 2 O2 = H(+) + H2O2 + L-topaquinyl-[protein]
RHEA:26319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate
RHEA:19266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH
RHEA:15329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + NAD(+) = H(+) + N-carbamoyl-2-oxoglycine + NADH
REACT:R-PFA-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-SPO-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)
REACT:R-HSA-352103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Homo sapiens)
RHEA:30061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orotate + succinate => (S)-dihydroorotate + fumarate
RHEA:63825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate => aspulvinone E + H2O
REACT:R-CEL-6809720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)
REACT:R-SSC-391158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP alpha binds CD47 (Sus scrofa)
RHEA:71511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phylloquinone(out) = phylloquinone(in)
RHEA:44704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:15897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-acetamidobutyrate deacetylase"
RHEA:15897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanoate + H2O = 4-aminobutanoate + acetate
RHEA:15897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-acetamidopentanoate + H2O = 5-aminopentanoate + acetate
RHEA:15897	skos:prefLabel	"4-acetamidobutyrate deacetylase"
REACT:R-HSA-5654646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
REACT:R-CFA-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Canis familiaris)
REACT:R-HSA-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Homo sapiens)
RHEA:16643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ethanol + H(+) => a long-chain fatty acyl ethyl ester + H2O
RHEA:26313	skos:prefLabel	"2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase"
RHEA:26313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = dihydroxyacetone phosphate + L-aspartate 4-semialdehyde
RHEA:26313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase"
REACT:R-DDI-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Dictyostelium discoideum)
REACT:R-MMU-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Mus musculus)
RHEA:24249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-alanine => glycine + pyruvate
REACT:R-HSA-1592235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of POLG2 (Homo sapiens)
REACT:R-DME-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Drosophila melanogaster)
REACT:R-SSC-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Sus scrofa)
REACT:R-DRE-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Danio rerio)
RHEA:22534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyoctanedioyl-CoA => (2E)-octenedioyl-CoA + H2O
REACT:R-DRE-5665998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 binds SRF (Danio rerio)
REACT:R-CFA-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Canis familiaris)
REACT:R-DRE-514604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Danio rerio)
REACT:R-SSC-4724279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Sus scrofa)
RHEA:26499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP
RHEA:58626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanamide + glyoxylate => N-dodecanoyl-(2S)-hydroxyglycine
REACT:R-MMU-3791319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NID1 degradation by MMP19 (Mus musculus)
GO:0008531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin kinase activity
GO:0008531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavine kinase activity
GO:0008531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin kinase (phosphorylating)
GO:0008531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavokinase activity
GO:0008531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FK
GO:0008531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:riboflavin 5'-phosphotransferase activity
REACT:R-HSA-2161613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Homo sapiens)
REACT:R-DRE-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Danio rerio)
RHEA:21555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
REACT:R-BTA-5665989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIAPH1 binds RHOA:GTP (Bos taurus)
REACT:R-XTR-427528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Xenopus tropicalis)
REACT:R-MMU-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Mus musculus)
RHEA:29617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltotetraose + beta-D-glucose => alpha-maltotriose + beta-maltose
RHEA:68204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoylglycerol + octadecanoyl-CoA = 1,2-dihexanoyl-3-octadecanoylglycerol + CoA
REACT:R-RNO-190385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3b (Rattus norvegicus)
REACT:R-BTA-977371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates Factor H-boundC3b (Bos taurus)
REACT:R-GGA-6781899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds SIAH2 (Gallus gallus)
RHEA:18324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-leucine <=> 4-methyl-2-oxopentanoate + L-glutamate
REACT:R-SSC-6804441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF34 or RFFL ubiquitinates phosphorylated TP53 (Sus scrofa)
RHEA:17313	skos:prefLabel	"histidine--tRNA ligase"
RHEA:17313	skos:altLabel	"histidyl-tRNA synthetase"
RHEA:17313	skos:altLabel	"histidine translase"
RHEA:17313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
RHEA:17313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histidine--tRNA ligase"
REACT:R-BTA-173754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Properdin stabilizes C3b:Bb bound to cell surfaces (Bos taurus)
RHEA:28107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol 1-phosphate + NAD(+) => H(+) + keto-D-tagatose 6-phosphate + NADH
REACT:R-RNO-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
RHEA:53558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-69685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TP53 (Drosophila melanogaster)
REACT:R-MMU-9026408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Mus musculus)
RHEA:55451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:70867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(out) + L-glutamine(in) + Na(+)(out) = L-alanine(in) + L-glutamine(out) + Na(+)(in)
RHEA:15853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) = 17alpha-hydroxyprogesterone + H(+) + NADPH
RHEA:15853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH
RHEA:15853	skos:prefLabel	"20alpha-hydroxysteroid dehydrogenase"
RHEA:15853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"20alpha-hydroxysteroid dehydrogenase"
RHEA:27950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(in) = L-phenylalanine(out)
RHEA:25716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-2855054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-2 binds to molecular patterns on the target cell surface  (Canis familiaris)
RHEA:53809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:21034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acceptor beta-D-glucuronoside + H(+) + UDP => glucuronate acceptor + UDP-alpha-D-glucuronate
RHEA:68438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2
GO:0015615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allose-importing ATPase activity
GO:0015615	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-allose porter activity
REACT:R-HSA-5685902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Homo sapiens)
REACT:R-CEL-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Caenorhabditis elegans)
GO:0016002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen-sulfide:acceptor oxidoreductase activity
GO:0016002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphite reductase activity
GO:0016002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite reductase activity
GO:0016002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen-sulfide:(acceptor) oxidoreductase activity
GO:0016002	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	siroheme sulfite reductase activity
GO:0016002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	assimilatory sulfite reductase activity
GO:0016002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	assimilatory-type sulfite reductase activity
RHEA:12834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-glutamate + H2O => a carboxylate + D-glutamate
REACT:R-CFA-450222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Canis familiaris)
RHEA:14637	skos:prefLabel	"thiol sulfotransferase"
RHEA:14637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiol sulfotransferase"
RHEA:14637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate
RHEA:71620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + 2 thiosulfate(out) => (S)-malate(out) + 2 thiosulfate(in)
RHEA:11678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribonate + 2 H(+) + NADPH => D-ribose + H2O + NADP(+)
GO:0043767	skos:altLabel	"PylRS"
GO:0043767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PylRS
GO:0043767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrrolysyl-tRNA synthetase activity
GO:0043767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)
GO:0043767	skos:prefLabel	"pyrrolysine--tRNA(Pyl) ligase"
GO:0043767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrrolysine-tRNA ligase activity
GO:0043767	skos:altLabel	"pyrrolysyl-tRNA synthetase"
GO:0043767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrrolysine--tRNA(Pyl) ligase"
REACT:R-SCE-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Saccharomyces cerevisiae)
RHEA:37224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA
REACT:R-SCE-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Saccharomyces cerevisiae)
RHEA:33040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Mus musculus)
RHEA:64605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UTP => diphosphate + uridylyl-L-seryl-[protein]
RHEA:33798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sucrose <=> alpha-D-glucose + beta-D-fructose
REACT:R-SSC-390438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR2 reduces PalmCoA to HXOL (Sus scrofa)
REACT:R-SSC-212642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamine transport into neurons (Sus scrofa)
RHEA:20308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + H2O + NAD(+) <=> 4-hydroxybenzoate + 2 H(+) + NADH
RHEA:58059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypotaurine + pyruvate <=> 2-sulfinoacetaldehyde + L-alanine
REACT:R-RNO-191972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol is 7alpha-hydroxylated (Rattus norvegicus)
REACT:R-HSA-5672954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Homo sapiens)
RHEA:34211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylecgonone reductase"
RHEA:34211	skos:prefLabel	"methylecgonone reductase"
RHEA:34211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecgonine methyl ester + NADP(+) = ecgonone methyl ester + H(+) + NADPH
REACT:R-CEL-209960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diiodinated tyrosine can be deiodinated (Caenorhabditis elegans)
RHEA:66278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP => tigogenin + UDP-alpha-D-glucose
REACT:R-BTA-139920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tBID to mitochondria (Bos taurus)
REACT:R-SCE-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)
RHEA:47335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty aldehyde + phosphoethanolamine => a sphingoid 1-phosphate
GO:0050293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	testololactone lactonohydrolase activity
GO:0050293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + testololactone = H(+) + testolate
GO:0050293	skos:prefLabel	"steroid-lactonase"
GO:0050293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid-lactonase activity
GO:0050293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steroid-lactonase"
REACT:R-CFA-629588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Canis familiaris)
REACT:R-SSC-1296043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of HCN channels (Sus scrofa)
REACT:R-CEL-6801808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A,REG3G binds bacterial peptidoglycan (Caenorhabditis elegans)
REACT:R-DDI-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)
RHEA:51366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine
RHEA:54420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)
RHEA:54420	skos:prefLabel	"cyclic-di-AMP phosphodiesterase"
RHEA:54420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclic-di-AMP phosphodiesterase"
REACT:R-GGA-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Gallus gallus)
REACT:R-HSA-9687388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)
REACT:R-XTR-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Xenopus tropicalis)
RHEA:53263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-879907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate the receptor (Canis familiaris)
RHEA:47753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine => 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9022315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds DGCR8 (Homo sapiens)
REACT:R-SSC-202325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Gads to LAT (Sus scrofa)
RHEA:63340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-amino acyl-L-seryl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate
REACT:R-RNO-139919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BIM to mitochondria (Rattus norvegicus)
RHEA:20185	skos:prefLabel	"CMP-N-acylneuraminate phosphodiesterase"
RHEA:20185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CMP-N-acyl-beta-neuraminate + H2O = an N-acylneuraminate + CMP + H(+)
RHEA:20185	skos:altLabel	"CMP-sialate hydrolase"
RHEA:20185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CMP-N-acylneuraminate phosphodiesterase"
REACT:R-MMU-9708457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HM13 cleaves HMOX1 dimer (Mus musculus)
REACT:R-HSA-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Homo sapiens)
REACT:R-HSA-163554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated HSL dimer translocates from the cytosol to the lipid particle (Homo sapiens)
RHEA:18839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + taxuyunnanin C => 10-deacetyltaxuyunnanin C + acetyl-CoA
RHEA:54570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pseudouridine in rRNA => a uridine in rRNA
REACT:R-BTA-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Bos taurus)
REACT:R-SSC-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)
REACT:R-DRE-982775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor dimerizes (Danio rerio)
REACT:R-PFA-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Plasmodium falciparum)
REACT:R-RNO-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Rattus norvegicus)
RHEA:26546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alaninamide + H2O = beta-alanine + NH4(+)
RHEA:51762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate
REACT:R-GGA-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Gallus gallus)
REACT:R-BTA-391937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP/CysLT receptor can bind cysteinyl leukotrienes (Bos taurus)
REACT:R-BTA-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Bos taurus)
RHEA:45902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-saturated (2E)-enoyl-CoA => a (3Z)-enoyl-CoA
RHEA:61852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesterol + UDP-alpha-D-glucose = campesteryl 3-beta-D-glucoside + H(+) + UDP
REACT:R-MMU-5687123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S115 MAPKAPK5 translocates to the cytosol (Mus musculus)
RHEA:52614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein] => 3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:30516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + thermospermine
RHEA:71457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate => goralatide + H2O
REACT:R-DME-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Drosophila melanogaster)
REACT:R-DRE-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Danio rerio)
REACT:R-GGA-8875443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates LRIG1 (Gallus gallus)
REACT:R-DRE-6792445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPH, I hydrolyse PA to 2-acyl LPA (Danio rerio)
REACT:R-CEL-3361751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin is replaced by repression complexes at the promoter (Caenorhabditis elegans)
REACT:R-XTR-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Xenopus tropicalis)
RHEA:53307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 2 ATP + 2 cob(II)alamin <=> A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate
RHEA:72347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole = 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
GO:0035529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH pyrophosphatase activity
GO:0035529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH pyrophosphohydrolase activity
GO:0035529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH diphosphatase activity
RHEA:14329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate
REACT:R-SSC-398185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG binds plexin B1 (Sus scrofa)
REACT:R-SSC-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Sus scrofa)
REACT:R-HSA-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Homo sapiens)
REACT:R-HSA-265425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with von Willbrand Factor (Homo sapiens)
REACT:R-DRE-210290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHIP (Danio rerio)
REACT:R-SSC-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Sus scrofa)
REACT:R-MMU-139897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAD displaces tBID from BCL-2 sequestration (Mus musculus)
RHEA:22305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + keto-D-fructose => 5-dehydro-D-fructose + a ubiquinol
RHEA:17816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-altronate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH
RHEA:40412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)
RHEA:10176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH
RHEA:10176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-methylindole-3-pyruvate reductase"
RHEA:10176	skos:prefLabel	"beta-methylindole-3-pyruvate reductase"
GO:0103088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(6'-methylthio)hexylmalate synthase activity
REACT:R-HSA-8938300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vanin hydrolyses pantetheine to PanK, 2AET (Homo sapiens)
GO:0047098	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Latia luciferin monooxygenase (demethylating)
GO:0047098	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)
GO:0047098	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	luciferase (Latia luciferin)
GO:0047098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latia-luciferin monooxygenase (demethylating) activity
REACT:R-XTR-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)
RHEA:32004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene
RHEA:31111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + butanoyl-CoA = 3-oxohexanoyl-CoA + CoA
RHEA:61827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pregnenolone + UDP-alpha-D-glucose <=> H(+) + pregnenolone 3-beta-D-glucoside + UDP
RHEA:42054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinal + H(+) + NADH => 9-cis-retinol + NAD(+)
RHEA:32226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADHX + ADP <=> AMP + H(+) + NADH + phosphate
REACT:R-MMU-9708517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)
GO:0047900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate kinase"
GO:0047900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + formate = ADP + formyl phosphate
GO:0047900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:formate phosphotransferase activity
GO:0047900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate kinase activity
GO:0047900	skos:prefLabel	"formate kinase"
RHEA:64045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine
RHEA:16005	skos:prefLabel	"galactarate dehydratase"
RHEA:16005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactarate dehydratase"
RHEA:16005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O
RHEA:16005	skos:altLabel	"D-galactarate hydro-lyase"
RHEA:54067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-cubebol + diphosphate
REACT:R-DRE-8948027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial phospholipids (Danio rerio)
REACT:R-MMU-2160492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4I1:FAD oxidises L-Phe to kPPV (Mus musculus)
REACT:R-CFA-2424476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV2/3 (Canis familiaris)
EC:1.10.99.-	skos:prefLabel	"With other acceptors"
EC:1.10.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
RHEA:72001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II => O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase]
RHEA:69887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + uridine(out) = Na(+)(in) + uridine(in)
RHEA:64105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] => 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]
RHEA:45365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine => (11Z)-eicosenoate + (4R)-hydroxysphinganine
RHEA:29994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-lyxopyranose(in) <=> H(+)(out) + L-lyxopyranose(out)
RHEA:10147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 3'-phosphate + H2O <=> a ribonucleoside + phosphate
REACT:R-BTA-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)
REACT:R-DRE-71825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Danio rerio)
REACT:R-SSC-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Sus scrofa)
RHEA:58029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH => a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)
REACT:R-CFA-1483002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to 1-acyl GO3P by GNPAT (Canis familiaris)
RHEA:65270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin F + H2O + NADP(+) => 3-hydroxypentacecilide A + H(+) + NADPH + O2
RHEA:40198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA
RHEA:48153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b(d18:1(4E)/18:0) + H2O => ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate
REACT:R-RNO-141423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the MCC complex to the APC/C complex (Rattus norvegicus)
REACT:R-CEL-183094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds CBL:Beta-Pix (Caenorhabditis elegans)
REACT:R-CFA-265296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Canis familiaris)
REACT:R-BTA-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Bos taurus)
REACT:R-XTR-2168883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin:Hemoglobin binds CD163 (Xenopus tropicalis)
REACT:R-HSA-9661710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An unknown oxidase oxidises D-UBGN to UBN (Homo sapiens)
RHEA:39343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA = (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O
RHEA:28841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + Zn(2+)(out) => H(+)(out) + Zn(2+)(in)
REACT:R-GGA-5610737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH bind and ubiquitnate GLI1 (Gallus gallus)
REACT:R-HSA-8876868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE1 cleaves EDN1(53-90) (Homo sapiens)
REACT:R-CFA-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Canis familiaris)
REACT:R-DME-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Drosophila melanogaster)
RHEA:62986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + NH4(+) => H2O + hexadecanamide
REACT:R-HSA-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Homo sapiens)
REACT:R-DRE-8948066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-IRAK1 dissociates (Danio rerio)
RHEA:29697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(I)inamide(out) => cob(I)inamide(in)
REACT:R-GGA-265427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Gallus gallus)
RHEA:66370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA => 6-methyl-3,7-dioxodecanedioyl-CoA + CoA
REACT:R-DME-2028679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Drosophila melanogaster)
REACT:R-DDI-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Dictyostelium discoideum)
RHEA:37092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA
REACT:R-CFA-351863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active caspase-8 to the mitochondrial membrane (Canis familiaris)
RHEA:34192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)
RHEA:54633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + tetradecanoyl-CoA => 2-hydroxytetradecanoyl-CoA + CO2 + succinate
RHEA:19903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,beta-didehydrotryptophan + H2O2 => L-tryptophan + O2
RHEA:57906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2
GO:0004826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine translase activity
GO:0004826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine-tRNA synthetase activity
GO:0004826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanyl-tRNA synthetase activity
GO:0004826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine-tRNA ligase activity
GO:0004826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanyl-tRNA ligase activity
GO:0004826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanyl-tRNA synthetase activity
GO:0004826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanyl-transfer RNA synthetase activity
GO:0004826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanyl-transfer RNA ligase activity
GO:0004826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine:tRNAPhe ligase (AMP-forming) activity
GO:0004826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanyl-transfer ribonucleate synthetase activity
REACT:R-HSA-6806423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates DDB2 expression (Homo sapiens)
REACT:R-MMU-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Mus musculus)
RHEA:43530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomalonate semialdehyde + H(+) + NADH => L-serine + NAD(+)
GO:0102502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-glucose-starch glucosyltransferase activity
RHEA:66875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Homo sapiens)
REACT:R-CEL-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Caenorhabditis elegans)
REACT:R-HSA-9028526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2 or NR1H3, NRIP1 bind the SCD gene (Homo sapiens)
REACT:R-DRE-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Danio rerio)
RHEA:37720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
RHEA:67316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine = (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine
RHEA:59594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-alanyl-L-arginine + H(+) + phosphate => ATP + beta-alanine + L-arginine
GO:0016608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHRF activity
GO:0016608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHRH activity
GO:0016608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth hormone-releasing hormone activity
REACT:R-MMU-432121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL binds to LRP8 (Mus musculus)
REACT:R-SPO-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Schizosaccharomyces pombe)
REACT:R-CFA-976991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor ligands bind the prolactin receptor (Canis familiaris)
REACT:R-DME-5696968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP20, USP33 deubiquitinate ADRB2 (Drosophila melanogaster)
REACT:R-BTA-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)
RHEA:49188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d = a 3-vinylbacteriochlorophyllide d + H2O
RHEA:49188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-vinylbacteriochlorophyllide d 3(1)-hydratase"
RHEA:49188	skos:prefLabel	"3-vinylbacteriochlorophyllide d 3(1)-hydratase"
RHEA:45990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O => 3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2
REACT:R-SCE-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Saccharomyces cerevisiae)
REACT:R-XTR-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Xenopus tropicalis)
REACT:R-CFA-450434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Canis familiaris)
REACT:R-RNO-8987043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22RA1 binds JAK1 (Rattus norvegicus)
GO:0098607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylselenocysteine deselenhydrase activity
GO:0098607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSec is hydrolysed to MeSeH by PXLP-K212-CTH (Homo sapiens)
REACT:R-SPO-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)
REACT:R-CEL-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Caenorhabditis elegans)
RHEA:67087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + hexacosanoate(in) <=> ADP + H(+) + hexacosanoate(out) + phosphate
REACT:R-MMU-69891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of CHEK2 by ATM (Mus musculus)
GO:0097507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine DNA N-glycosylase activity
GO:0097507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hypoxanthine-DNA glycosylase activity
REACT:R-RNO-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Rattus norvegicus)
RHEA:34889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenate(out) => selenate(in)
REACT:R-DRE-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Danio rerio)
REACT:R-SSC-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Sus scrofa)
REACT:R-SSC-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Sus scrofa)
RHEA:70638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
EC:1.14.13.2	skos:prefLabel	"4-hydroxybenzoate 3-monooxygenase"
EC:1.14.13.2	skos:altLabel	"p-hydroxybenzoic acid hydroxylase"
EC:1.14.13.2	skos:altLabel	"p-hydroxybenzoate hydroxylase"
EC:1.14.13.2	skos:altLabel	"para-hydroxybenzoate hydroxylase"
EC:1.14.13.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoate 3-monooxygenase"
REACT:R-SSC-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Sus scrofa)
REACT:R-DRE-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Danio rerio)
RHEA:61130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase] => O2 + quercetin + reduced [NADPH--hemoprotein reductase]
RHEA:64955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCDP + H2O <=> dCMP + H(+) + phosphate
REACT:R-MMU-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Mus musculus)
RHEA:33031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-fructose + NADH = D-sorbitol + NAD(+)
REACT:R-SSC-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Sus scrofa)
GO:0015371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose:sodium symporter activity
REACT:R-RNO-4827382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Rattus norvegicus)
REACT:R-DDI-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)
REACT:R-SPO-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Schizosaccharomyces pombe)
RHEA:35097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + trimethylamine => choline
RHEA:52106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+) => a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate
RHEA:50172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine
REACT:R-DME-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Drosophila melanogaster)
REACT:R-RNO-1295621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)
REACT:R-CEL-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Caenorhabditis elegans)
REACT:R-HSA-5634228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 is cleaved by caspases (Homo sapiens)
RHEA:42941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(34) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Gallus gallus)
RHEA:66018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypobromite => bromide + H2O2
RHEA:62166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine + N-acetyl-D-glucosamine => beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O
EC:3.4.24.16	skos:prefLabel	"neurolysin"
EC:3.4.24.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neurolysin"
EC:3.4.24.16	skos:altLabel	"neurotensin endopeptidase"
RHEA:39004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-HSA-167191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
RHEA:54206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2
REACT:R-SSC-2022379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Sus scrofa)
RHEA:30947	skos:prefLabel	"10-epi-gamma-eudesmol synthase"
RHEA:30947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"10-epi-gamma-eudesmol synthase"
RHEA:30947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = 10-epi-gamma-eudesmol + diphosphate
GO:0016863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular isomerase activity, transposing C=C bonds
GO:0016863	skos:prefLabel	"Transposing C=C bonds"
GO:0016863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular oxidoreductase activity, transposing C=C bonds
GO:0016863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transposing C=C bonds"
REACT:R-RNO-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Rattus norvegicus)
REACT:R-CEL-6814096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds SCOC (Caenorhabditis elegans)
REACT:R-BTA-163820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Bos taurus)
REACT:R-BTA-2730899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BCL10 and MALT1 (Bos taurus)
RHEA:42850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+) => 8-demethyltetracenomycin C + dTDP-beta-L-rhamnose
REACT:R-BTA-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Bos taurus)
REACT:R-SPO-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Schizosaccharomyces pombe)
RHEA:35221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dAMP + H(+) + phosphate => 8-oxo-dADP + H2O
REACT:R-SSC-8849878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSD-95 binds NMDA receptor (Sus scrofa)
RHEA:14976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate <=> D-aspartate
RHEA:29414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate(in) + H(+)(in) <=> glycolate(out) + H(+)(out)
REACT:R-GGA-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Gallus gallus)
GO:0099521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
GO:0099521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential
GO:0099521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
REACT:R-SPO-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Schizosaccharomyces pombe)
RHEA:56169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-DRE-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Danio rerio)
REACT:R-XTR-9762343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDL:ALB dissociates (Xenopus tropicalis)
REACT:R-HSA-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Homo sapiens)
RHEA:32443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:32443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zeaxanthin epoxidase"
RHEA:32443	skos:altLabel	"zea-epoxidase"
RHEA:32443	skos:prefLabel	"zeaxanthin epoxidase"
RHEA:21455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 <=> a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical
REACT:R-DME-9654525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Drosophila melanogaster)
RHEA:12410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+) => L-lysine + NAD(+)
GO:0106256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroperoxy icosatetraenoate dehydratase activity
REACT:R-GGA-390593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Gallus gallus)
REACT:R-CEL-8851494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase7 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)
RHEA:56441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-GGA-9645520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Gallus gallus)
GO:0030197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular matrix constituent, lubricant activity
GO:0030197	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core matrisome
GO:0030197	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core extracellular matrix
REACT:R-RNO-5684108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 binds phosphorylated RBBP8 (Rattus norvegicus)
REACT:R-GGA-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Gallus gallus)
REACT:R-DRE-983285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B binds RAD51C (Danio rerio)
REACT:R-HSA-749448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
REACT:R-XTR-879584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO3A1 isoform 1 has abroad substrate specificity (Xenopus tropicalis)
REACT:R-GGA-351877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 2 (Gallus gallus)
REACT:R-XTR-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Xenopus tropicalis)
REACT:R-CEL-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Caenorhabditis elegans)
RHEA:58002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose
RHEA:69545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptidine => 6-O-adenylylstreptidine + diphosphate
RHEA:35012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fucose(in) + H(+)(in) => D-fucose(out) + H(+)(out)
RHEA:50875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 <=> (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate
REACT:R-BTA-391936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP1 receptor can bind PGE2 (Bos taurus)
RHEA:40002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid 1-phosphate <=> a fatty aldehyde + phosphoethanolamine
REACT:R-GGA-211178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO1A is excluded from the nucleus (Gallus gallus)
REACT:R-DRE-5686642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD52 promotes single strand annealing at resected DNA DSBs (Danio rerio)
REACT:R-DDI-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Dictyostelium discoideum)
RHEA:19988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADH + S-formylglutathione
REACT:R-CFA-163099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alignment Of The RNA Template On The Telomeric Chromosome End (Canis familiaris)
REACT:R-XTR-3257122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Xenopus tropicalis)
GO:0070380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high mobility group box 1 receptor activity
GO:0070380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 receptor activity
RHEA:58540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-dodecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine
RHEA:54412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-5beta-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH
REACT:R-HSA-77338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Homo sapiens)
REACT:R-DRE-8955285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Danio rerio)
REACT:R-MMU-211951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1B1 4-hydroxylates EST17b (Mus musculus)
RHEA:66463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O <=> 14betaH-scalarane-17alpha-19-diol
RHEA:17711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-nonaprenyl diphosphate
REACT:R-SSC-2029272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of PLCG from FCGR (Sus scrofa)
REACT:R-SSC-173483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAMBI interferes with the interaction of type I receptor with type II receptor (Sus scrofa)
REACT:R-RNO-2426259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Rattus norvegicus)
RHEA:22525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + a carotenoid beta-end derivative => a carotenoid phi-end derivative + 2 AH2
RHEA:21808	skos:altLabel	"cyclo(Gly-Gly) hydrolase"
RHEA:21808	skos:prefLabel	"2,5-dioxopiperazine hydrolase"
RHEA:21808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,5-dioxopiperazine hydrolase"
RHEA:21808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopiperazine + H2O = glycylglycine
GO:0031151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K79 methyltransferase activity
GO:0031151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-methyltransferase activity (H3-K79 specific)
GO:0031151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H3-K79 specific)
GO:0031151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-K79 specific)
GO:0031151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K79 methylase activity
GO:0031151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3K79 methyltransferase activity
REACT:R-BTA-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Bos taurus)
RHEA:16250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate => beta-D-glucose 6-phosphate
RHEA:68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esculetin + S-adenosyl-L-methionine = H(+) + isoscopoletin + S-adenosyl-L-homocysteine
REACT:R-RNO-9629492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves spiroiminodihydantoin (Rattus norvegicus)
RHEA:15532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(2-ethylhexyl)phthalate + H2O <=> 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)
REACT:R-XTR-5665761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL3 binds RHOC:GTP (Xenopus tropicalis)
RHEA:51989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => 18S-resolvin E1
REACT:R-GGA-1604690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MMP9 intermediate form by MMPs (Gallus gallus)
REACT:R-CEL-8948063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Caenorhabditis elegans)
REACT:R-HSA-5628901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates TIGAR expression (Homo sapiens)
REACT:R-RNO-9009485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34:CSF1 binds CSF1R (Rattus norvegicus)
REACT:R-DME-201457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP2 binds to the receptor complex (Drosophila melanogaster)
RHEA:45274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxy-(9Z)-octadecenoate + phosphate => 12-phosphooxy-(9Z)-octadecenoate + H2O
REACT:R-DME-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Drosophila melanogaster)
RHEA:21327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + reduced [rubredoxin] + superoxide <=> H2O2 + oxidized [rubredoxin]
REACT:R-MMU-2562594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated OPTN translocates to the nucleus (Mus musculus)
REACT:R-RNO-445071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reinsertion of L1 into the plasma membrane (Rattus norvegicus)
REACT:R-CFA-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Canis familiaris)
REACT:R-MMU-9706315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SH2B3 (Mus musculus)
RHEA:24202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aniline + CO2 => 4-aminobenzoate + H(+)
RHEA:46683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + NADH <=> 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)
REACT:R-HSA-5617896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retinoic acid activates HOXD4 chromatin (Homo sapiens)
REACT:R-MMU-210274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP beta binds TYROBP (Mus musculus)
RHEA:65703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:36754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:57232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GDP
GO:0047240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactosylceramide beta-1,3-galactosyltransferase activity
GO:0047240	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity
GO:0047240	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity
GO:0047240	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity
REACT:R-RNO-2396009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds c-di-GMP (Rattus norvegicus)
REACT:R-RNO-176702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Processive Complex and Completed Telomere End (Rattus norvegicus)
REACT:R-BTA-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Bos taurus)
REACT:R-GGA-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Gallus gallus)
REACT:R-SCE-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Saccharomyces cerevisiae)
RHEA:42872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine
REACT:R-DRE-9028730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FRS2 (Danio rerio)
RHEA:39190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydocosanoyl-CoA <=> (2E)-docosenoyl-CoA + H2O
GO:0008876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinoprotein glucose dehydrogenase activity
GO:0008876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose:ubiquinone oxidoreductase activity
GO:0008876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose dehydrogenase (PQQ-dependent) activity
GO:0008876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose dehydrogenase (pyrroloquinoline-quinone) activity
GO:0008876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinoprotein D-glucose dehydrogenase activity
GO:0008876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity
REACT:R-CEL-8932355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)
RHEA:47515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isocholate + NAD(+)
RHEA:43849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + arsenate + H(+) => [thioredoxin]-disulfide + arsenite + H2O
REACT:R-GGA-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Gallus gallus)
RHEA:20862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-isopiperitenone + H(+) + NADH => (1S,6R)-isopiperitenol + NAD(+)
REACT:R-HSA-9603302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (peptide) binds IIa (Homo sapiens)
REACT:R-HSA-3769383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBY1 binds beta-catenin (Homo sapiens)
REACT:R-DRE-9750226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 binds IKBKB and CHUK (Danio rerio)
REACT:R-MMU-8855711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Mus musculus)
REACT:R-SSC-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Sus scrofa)
REACT:R-HSA-5211356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anthrax lef cleaves target cell MAP2K2 (MEK2) (Homo sapiens)
RHEA:67242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H(+) + L-methionine => (R)-S-adenosyl-L-methionine + H2O
RHEA:49975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-182969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:CBL) (Rattus norvegicus)
RHEA:62154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGDP + dTDP => dGMP + dTTP
GO:0016707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gibberellin 3beta-dioxygenase activity
GO:0016707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gibberellin 3-beta-hydroxylase activity
GO:0016707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gibberellin 3beta-hydroxylase activity
GO:0016707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin 3-beta-dioxygenase activity
GO:0016707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)
GO:0016707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)
GO:0102118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A4 carboxyl methyltransferase activity
REACT:R-RNO-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Rattus norvegicus)
RHEA:64920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate
REACT:R-HSA-6784319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)
REACT:R-SSC-2327738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Sus scrofa)
REACT:R-HSA-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Homo sapiens)
REACT:R-HSA-9664214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
REACT:R-CFA-2168888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha1-Microglobulin binds heme (Canis familiaris)
RHEA:66670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Danio rerio)
REACT:R-SCE-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Saccharomyces cerevisiae)
REACT:R-CFA-5674366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RD binds p-2S MAP2Ks and MAPKs (Canis familiaris)
REACT:R-RNO-76475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Rattus norvegicus)
RHEA:47416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an NDP-alpha-D-glucose + D-glucose = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)
REACT:R-BTA-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Bos taurus)
RHEA:33311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + hydroxylamine + NH4(+) = 2 AH2 + H(+) + H2O + N2
RHEA:45368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (9Z)-octadecenoate
REACT:R-SSC-77592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Intronless Pre-mRNA at 3'-end (Sus scrofa)
GO:0062083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLA-G specific inhibitory MHC class Ib receptor activity
REACT:R-BTA-2176475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Bos taurus)
REACT:R-MMU-168140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Mus musculus)
REACT:R-RNO-200318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Rattus norvegicus)
REACT:R-BTA-141139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of TRAIL:TRAIL receptor complex (Bos taurus)
GO:0043879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate transmembrane transporter activity
GO:0043879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolate permease
GO:0043879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glcA
GO:0043879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolic acid transmembrane transporter activity
GO:0043879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyacetic acid transmembrane transporter activity
GO:0043879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate(in) = glycolate(out)
REACT:R-DRE-2197691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIP binds WASP,N-WASP, activating them (Danio rerio)
RHEA:51471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + a quinone <=> a quinol + pyruvate
REACT:R-HSA-9032841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds CDK5 (Homo sapiens)
REACT:R-SSC-3772430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNBIP1 binds beta-catenin (Sus scrofa)
RHEA:13510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-glucosamine
RHEA:23538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate => alpha-D-glucose 1-phosphate
RHEA:61722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-dehydro-D-guloside + H(+) + NADH => a D-guloside + NAD(+)
REACT:R-GGA-8944262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type X (Gallus gallus)
REACT:R-CEL-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Caenorhabditis elegans)
REACT:R-HSA-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Homo sapiens)
GO:0004115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic AMP-specific phosphodiesterase activity
GO:0004115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cAMP-specific phosphodiesterase activity
GO:0004115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP-specific phosphodiesterase activity
GO:0004115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity
GO:0004115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5' cAMP-specific phosphodiesterase activity
GO:0004115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic-AMP-specific phosphodiesterase activity
REACT:R-DRE-77329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Danio rerio)
GO:0034943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity
REACT:R-GGA-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Gallus gallus)
REACT:R-GGA-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Gallus gallus)
GO:0047743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlordecone reductase activity
GO:0047743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlordecone-alcohol:NADP+ 2-oxidoreductase activity
GO:0047743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH
GO:0047743	skos:prefLabel	"chlordecone reductase"
GO:0047743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDR activity
GO:0047743	skos:altLabel	"CDR"
GO:0047743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlordecone reductase"
REACT:R-CFA-8850961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREX2 binds PTEN and inhibits it (Canis familiaris)
REACT:R-XTR-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Xenopus tropicalis)
RHEA:50093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + taurine => an N-fatty acyl-taurine + CoA + H(+)
RHEA:38942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioscin + 2 H2O <=> diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose
REACT:R-GGA-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)
REACT:R-CFA-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Canis familiaris)
RHEA:46681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + NADH => 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)
REACT:R-CFA-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Canis familiaris)
RHEA:12601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate
RHEA:12601	skos:prefLabel	"2-aminoadipate transaminase"
RHEA:12601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-aminoadipate transaminase"
RHEA:12601	skos:altLabel	"2-aminoadipate aminotransferase"
REACT:R-BTA-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Bos taurus)
RHEA:36069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine => Co-precorrin-6B + S-adenosyl-L-methionine
REACT:R-XTR-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Xenopus tropicalis)
REACT:R-HSA-9017507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ binds effectors at the plasma membrane (Homo sapiens)
RHEA:15736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O <=> (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2
RHEA:27777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-4084994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU3 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)
RHEA:33567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ethanol = acetaldehyde + AH2
REACT:R-DME-3465545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Drosophila melanogaster)
RHEA:38887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexanoyl-sphinganine = hexanoate + sphinganine
REACT:R-XTR-5682983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates WHSC1 (Xenopus tropicalis)
RHEA:42117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH
REACT:R-DRE-139898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 activates BID by cleavage (Danio rerio)
RHEA:37198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-octadecanoyl-sn-glycero-3-phosphate + CoA
EC:2.1.1.103	skos:prefLabel	"phosphoethanolamine N-methyltransferase"
EC:2.1.1.103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoethanolamine N-methyltransferase"
REACT:R-RNO-9026003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Rattus norvegicus)
RHEA:53476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:54798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+)
REACT:R-HSA-9732692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Triazenes produce DNA damage in the form of O6-methylguanine (Homo sapiens)
RHEA:58565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine + NADP(+) => 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH
REACT:R-HSA-450690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Homo sapiens)
RHEA:24295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-glutamate <=> CoA + H(+) + N-acetyl-L-glutamate
RHEA:14801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP
RHEA:14801	skos:prefLabel	"phosphoglycerate kinase"
RHEA:14801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglycerate kinase"
RHEA:64913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O => a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate
REACT:R-SSC-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Sus scrofa)
REACT:R-MMU-110349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of UNG glycosylase by APEX1 at the AP site (Mus musculus)
RHEA:51189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide + superoxide => peroxynitrite
REACT:R-BTA-350901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is organified (Bos taurus)
REACT:R-SSC-8956031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Sus scrofa)
REACT:R-DDI-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Dictyostelium discoideum)
REACT:R-BTA-8855954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Bos taurus)
REACT:R-CEL-3134946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 ubiquitination by TRIM21 (Caenorhabditis elegans)
REACT:R-HSA-6784462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs (Homo sapiens)
REACT:R-SSC-187545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cks1 with SCF(Skp2) complex (Sus scrofa)
REACT:R-DRE-3371385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α is cleaved by ADAM17 (TACE) (Danio rerio)
RHEA:20510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + viomycin => ADP + H(+) + O-phosphoviomycin
RHEA:68698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate
REACT:R-DME-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)
GO:0005415	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleoside-sodium cotransporter activity
GO:0005415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside:sodium symporter activity
GO:0005415	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium-dependent nucleoside transporter activity
REACT:R-HSA-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)
REACT:R-RNO-5676917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Rattus norvegicus)
RHEA:13603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxo-L-proline + H(+) + NADH => cis-4-hydroxy-L-proline + NAD(+)
REACT:R-BTA-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Bos taurus)
RHEA:57619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-ML-236C-[compactin nonaketide synthase] + H2O <=> dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]
RHEA:61582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => (3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+)
REACT:R-RNO-6793666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the nucleus (Rattus norvegicus)
REACT:R-RNO-1306969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)
GO:0015141	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dicarboxylate (succinate/fumarate/malate) antiporter activity
GO:0015141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate transmembrane transporter activity
REACT:R-GGA-2484822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore assembly (Gallus gallus)
RHEA:52623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA <=> 2,2-dimethylpropanoyl-CoA
RHEA:69295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> goitrin + sulfate
REACT:R-SCE-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Saccharomyces cerevisiae)
REACT:R-HSA-1474158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCHFR binds to GCH1 and negatively regulates its activity (Homo sapiens)
REACT:R-DME-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Drosophila melanogaster)
REACT:R-DME-1855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Drosophila melanogaster)
RHEA:43628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-serine 3-dehydrogenase (NAD(+))"
RHEA:43628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NAD(+) = aminoacetaldehyde + CO2 + NADH
RHEA:43628	skos:prefLabel	"L-serine 3-dehydrogenase (NAD(+))"
RHEA:56568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine = globoside IV3GalNAc-Gb4Cer + H(+) + UDP
RHEA:69167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) <=> 2 H(+) + N-(2-carboxyethyl)putrescine + NADH
RHEA:18490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate + H(+) + hydrogencarbonate => carbamate + CO2
REACT:R-HSA-6788582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)
RHEA:37305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycyl-L-asparagine(in) + H(+) + phosphate => ATP + glycyl-L-asparagine(out) + H2O
RHEA:51273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-octadecenoyl)glycine
REACT:R-RNO-5676591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Rattus norvegicus)
REACT:R-HSA-6798031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates BTG2 expression (Homo sapiens)
REACT:R-RNO-9014627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDS dimers:PXLP dehydrate L-Thr to 2AA (Rattus norvegicus)
RHEA:21853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O
RHEA:61944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecholesterol + UDP-alpha-D-glucose = 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP
REACT:R-CFA-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Canis familiaris)
RHEA:52068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)
REACT:R-DRE-6807118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates monoubiquitinated PTEN (Danio rerio)
REACT:R-GGA-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Gallus gallus)
REACT:R-DRE-420580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:PVRL3 trans heterodimer formation (Danio rerio)
REACT:R-DDI-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Dictyostelium discoideum)
REACT:R-HSA-9683630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein translocates to the plasma membrane (Homo sapiens)
GO:0004729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxygen-dependent protoporphyrinogen oxidase activity
GO:0004729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoporphyrinogen-IX:oxygen oxidoreductase activity
REACT:R-MMU-9714924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to soluble TNF trimer (Mus musculus)
REACT:R-XTR-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Xenopus tropicalis)
RHEA:65511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 <=> H2O2 + NH4(+) + pre-mycofactocin
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	procollagen-lysine,2-oxoglutarate 5-dioxygenase activity
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysyl hydroxylase activity
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocollagen lysine dioxygenase activity
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysine hydroxylase activity
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocollagen lysyl hydroxylase activity
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	collagen lysine hydroxylase activity
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	procollagen-lysine 5-dioxygenase activity
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysylprotocollagen dioxygenase activity
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysine,2-oxoglutarate 5-dioxygenase activity
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocollagen lysine hydroxylase activity
GO:0008475	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysine-2-oxoglutarate dioxygenase activity
REACT:R-BTA-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Bos taurus)
REACT:R-RNO-9706345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)
RHEA:68631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]
RHEA:17264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aryl sulfate + H2O <=> a phenol + H(+) + sulfate
REACT:R-XTR-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Xenopus tropicalis)
GO:0018860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminobenzoate-CoA ligase activity
GO:0018860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminobenzoate-coenzyme A ligase activity
GO:0018860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthraniloyl coenzyme A synthetase activity
GO:0018860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminobenzoate coenzyme A ligase activity
GO:0018860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilate:CoA ligase (AMP-forming)
GO:0018860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate--CoA ligase activity
GO:0018860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate-CoA ligase activity
REACT:R-GGA-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Gallus gallus)
REACT:R-SSC-5690245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 binds DNAJB1 (Sus scrofa)
RHEA:44046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O
GO:0010851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclase regulator activity
REACT:R-MMU-8878050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 and EP300 (Mus musculus)
RHEA:24298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-carbamoyl-L-aspartate => (S)-dihydroorotate + H2O
RHEA:70232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) => (S)-2-benzoylsuccinyl-CoA + H(+) + NADH
RHEA:59289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O => D-glucose + sphing-4-enine
RHEA:60940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Bos taurus)
REACT:R-XTR-76496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Xenopus tropicalis)
REACT:R-CEL-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Caenorhabditis elegans)
RHEA:18793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
RHEA:10174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate dimer + H2O
REACT:R-HSA-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Homo sapiens)
RHEA:68726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase]
GO:1903879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta-hydroxyprogesterone binding
RHEA:29336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-glutamate => L-alanine + L-glutamate
RHEA:47942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine => ganglioside GM2 (d18:1(4E)) + H2O
REACT:R-CFA-212642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamine transport into neurons (Canis familiaris)
REACT:R-CEL-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Caenorhabditis elegans)
RHEA:23785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + L-proline => (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
REACT:R-MMU-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Mus musculus)
REACT:R-HSA-211948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 can N-demethylate loperamide (Homo sapiens)
REACT:R-BTA-450387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds the CRM1 nuclear export machinery (Bos taurus)
REACT:R-MMU-5690845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNIPs bind TNFAIP3 (A20) (Mus musculus)
RHEA:13283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-3-oxobutanoyl-CoA + H(+) + NADH => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+)
RHEA:47059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-HSA-8855825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTRA1 hydrolyzes ACAN (Aggrecan) (Homo sapiens)
REACT:R-MMU-373747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of nephrin by FYN (Mus musculus)
RHEA:55233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O
REACT:R-HSA-9021946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds GPRIN1 gene promoter (Homo sapiens)
REACT:R-DRE-190385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3b (Danio rerio)
REACT:R-BTA-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Bos taurus)
GO:0005159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	insulin-like growth factor
GO:0005159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF receptor binding
GO:0005159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin-like growth factor receptor binding
GO:0005159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	insulin-like growth factor receptor ligand
RHEA:16235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantoate + H(+) + NADPH => (R)-pantoate + NADP(+)
REACT:R-DRE-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Danio rerio)
RHEA:63681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-7,8-diammoniononanoate + CO2 => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)
GO:0102089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroscoulerine synthase activity
GO:0070883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-microRNA binding
GO:0070883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precursor microRNA binding
GO:0070883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-miRNA binding
RHEA:53094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine
RHEA:14315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine => 2-iodophenol + S-adenosyl-L-methionine
RHEA:36450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-proline(out) + H2O <=> ADP + glycyl-L-proline(in) + H(+) + phosphate
REACT:R-PFA-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Plasmodium falciparum)
REACT:R-SSC-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Sus scrofa)
RHEA:54187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-aromatic L-alpha-amino acid + H2O <=> a carboxylate + an aromatic L-alpha-amino acid
RHEA:25667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => beta-pinene + diphosphate
REACT:R-RNO-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Rattus norvegicus)
REACT:R-SSC-204850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Dok-2 (Sus scrofa)
RHEA:10810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-epoxypropylphosphonate + 2 H2O => (S)-2-hydroxypropylphosphonate + H2O2
RHEA:66130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + 3-phenylpyruvate => 2-oxobutanoate + L-phenylalanine
RHEA:71888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide
REACT:R-BTA-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Bos taurus)
REACT:R-DRE-6805546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I binds keratin type II (Danio rerio)
REACT:R-XTR-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)
RHEA:47536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isochenodeoxycholate + NADP(+)
GO:0034024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	YcjK
GO:0034024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:putrescine ligase (ADP-forming) activity
GO:0034024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-putrescine ligase activity
GO:0034024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamylputrescine synthetase activity
RHEA:63417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dichlorohydroquinone + FADH2 + O2 => 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O
REACT:R-RNO-211983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2J2 oxidises ARA (Rattus norvegicus)
RHEA:44620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine
REACT:R-MMU-5695964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD14B hydrolyses PNPB (Mus musculus)
REACT:R-BTA-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Bos taurus)
REACT:R-SSC-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Sus scrofa)
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-dependent RNA nucleotidyltransferase activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA-directed RNA polymerase I activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase I activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA-directed RNA polymerase II activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA nucleotidyltransferase (DNA-directed) activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C RNA formation factors
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase III activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA-directed RNA polymerase activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transcriptase
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-dependent ribonucleate nucleotidyltransferase activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic acid-dependent ribonucleic acid polymerase activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C ribonucleic acid formation factors
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-dependent RNA polymerase activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-directed 5'-3' RNA polymerase activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA-directed RNA polymerase III activity
GO:0003899	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II activity
RHEA:34932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathioselenol + NADPH => glutathione + hydrogenselenide + NADP(+)
RHEA:39960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate
GO:0004672	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protamine kinase activity
GO:0004672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase activity
RHEA:56489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Bos taurus)
GO:0018712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutyryl-CoA thiolase activity
REACT:R-GGA-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Gallus gallus)
RHEA:46233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CEL-265423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Fibrillin (Caenorhabditis elegans)
REACT:R-CFA-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Canis familiaris)
GO:0071791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCL5 binding
GO:0071791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulated upon Activation, Normal T-cell Expressed, and Secreted binding
GO:0071791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANTES binding
GO:0071791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine (C-C motif) ligand 5 binding
RHEA:64191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-tyrosine + H2O <=> a fatty acid + L-tyrosine
REACT:R-RNO-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Rattus norvegicus)
REACT:R-CFA-193789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Canis familiaris)
REACT:R-SSC-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Sus scrofa)
GO:0052748	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase activity
GO:0052748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baicalin beta-D-glucuronidase activity
GO:0052748	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	baicalinase activity
REACT:R-XTR-9661425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB dissociates (Xenopus tropicalis)
REACT:R-CFA-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Canis familiaris)
REACT:R-SSC-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Sus scrofa)
REACT:R-PFA-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Plasmodium falciparum)
REACT:R-XTR-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Xenopus tropicalis)
RHEA:29001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + homoserine lactone(out) => H(+)(out) + homoserine lactone(in)
REACT:R-HSA-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Homo sapiens)
REACT:R-MMU-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Mus musculus)
RHEA:50716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfone + FMNH2 + O2 = FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate
REACT:R-GGA-202344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ZAP-70 to phosphorylated ITAMs (Gallus gallus)
REACT:R-HSA-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Homo sapiens)
REACT:R-DRE-5610732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI3 (Danio rerio)
RHEA:51887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline betaine <=> D-proline betaine
REACT:R-GGA-177931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Gallus gallus)
RHEA:67744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O = 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate
REACT:R-BTA-9647631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds PIPs (Bos taurus)
RHEA:45484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pyruvate = acetaldehyde + CO2
RHEA:12501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH
REACT:R-PFA-5263616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeO2H is reduced to MeSeOH by TXNRD1 (Plasmodium falciparum)
REACT:R-DME-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Drosophila melanogaster)
RHEA:20375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + propanoyl-CoA => ATP + CoA + propanoate
GO:0140951	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K27 trimethylation
GO:0140951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-trimethyltransferase activity (H3-K27 specific)
GO:0140951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 trimethyltransferase activity
GO:0140951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(27) N-trimethyltransferase"
GO:0140951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K27 trimethylase activity
GO:0140951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 mono/di/trimethylase activity
GO:0140951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine
GO:0140951	skos:prefLabel	"[histone H3]-lysine(27) N-trimethyltransferase"
GO:0140951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 trimethylase activity
GO:0140951	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K27 trimethylation
REACT:R-CFA-5606996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds activated protein C (Canis familiaris)
RHEA:31182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxydodecanoyl-CoA + NAD(+) <=> 3-oxododecanoyl-CoA + H(+) + NADH
REACT:R-CFA-5607740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta phosphorylates CARD9 (Canis familiaris)
REACT:R-SSC-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)
RHEA:68148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octanone + H(+) + NADPH = (2R)-octan-2-ol + NADP(+)
REACT:R-DRE-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Danio rerio)
REACT:R-CFA-9011952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Canis familiaris)
RHEA:65678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine
RHEA:32365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + L-ascorbate => L-gulono-1,4-lactone + O2
RHEA:30291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linoleate 9S-lipoxygenase"
RHEA:30291	skos:prefLabel	"linoleate 9S-lipoxygenase"
RHEA:30291	skos:altLabel	"linoleate 9-lipoxygenase"
RHEA:30291	skos:altLabel	"9S-lipoxygenase"
RHEA:30291	skos:altLabel	"9-lipoxygenase"
RHEA:30291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate
RHEA:19306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA
REACT:R-PFA-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-PFA-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Plasmodium falciparum)
GO:0050396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vomifoliol:NAD+ 4'-oxidoreductase activity
GO:0050396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vomifoliol 4'-dehydrogenase activity
REACT:R-BTA-8854981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 in the RET complex is phosphorylated (Bos taurus)
REACT:R-DRE-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Danio rerio)
REACT:R-CFA-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Canis familiaris)
REACT:R-DME-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)
REACT:R-SSC-2187330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
REACT:R-XTR-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Xenopus tropicalis)
RHEA:33898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose <=> H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose
REACT:R-BTA-6785648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEMO1 binds RHOA:GTP:DIAPH1 (Bos taurus)
RHEA:41555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + ophiobolin F
RHEA:71301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-isoleucine(in) + 2 Na(+)(in) => chloride(out) + L-isoleucine(out) + 2 Na(+)(out)
REACT:R-GGA-2395314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysino-5-ketonorleucine cross-links (Gallus gallus)
REACT:R-GGA-168166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B complex is transported from cytosol to nucleus (Gallus gallus)
REACT:R-DRE-163214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)
RHEA:39726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol(in) <=> a 1,2-diacyl-sn-glycerol(out)
REACT:R-XTR-109449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Xenopus tropicalis)
REACT:R-MMU-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Mus musculus)
RHEA:25067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH
GO:0015218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine nucleotide transmembrane transporter activity
RHEA:47635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine + NAD(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)
RHEA:19769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phaseollidin hydratase"
RHEA:19769	skos:prefLabel	"phaseollidin hydratase"
RHEA:19769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phaseollidin hydrate = H2O + phaseollidin
REACT:R-RNO-2294600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates condensin II subunit NCAPD3 (Rattus norvegicus)
REACT:R-DME-2076611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3STs sulfate GlcN at C3 in heparan sulfate (Drosophila melanogaster)
REACT:R-SSC-8874202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the cytosol to the nucleus (Sus scrofa)
RHEA:45968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADH + O2 = 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)
REACT:R-CFA-8851890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates SHC1-2 (Canis familiaris)
RHEA:41903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] <=> 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:63309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate
REACT:R-MMU-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Mus musculus)
RHEA:55921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[cis-1,4-isoprene](n) + O2 => (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)
REACT:R-BTA-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)
RHEA:43932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH
REACT:R-MMU-159574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Mus musculus)
RHEA:49619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanal + H2O + NAD(+) <=> 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH
RHEA:53496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate
RHEA:63448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + CTP = CMP-(2-aminoethyl)phosphonate + diphosphate
RHEA:37138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-SPO-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-DRE-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Danio rerio)
RHEA:36408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + L-threonine => diphosphate + H2O + L-threonylcarbamoyladenylate
REACT:R-HSA-5662473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose (Homo sapiens)
RHEA:45681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)
GO:0061860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA clamp unloading activity
GO:0061860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA clamp unloader activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine-specific oxidized base lesion DNA N-glycosylase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Fpg protein
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleate glycosidase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA glycosylase/AP-lyase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-formamidopyrimidine glycosylase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	bifunctional DNA glycosylase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formamidopyrimidine-DNA glycosylase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized purine base lesion DNA N-glycosylase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Fapy-DNA glycosylase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	8-oxoguanine DNA glycosylase activity
GO:0008534	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA glycosylase/beta-lyase activity
REACT:R-MMU-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Mus musculus)
GO:0015414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type nitrate transporter activity
GO:0015414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate transporting ATPase activity
GO:0015414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled nitrate transmembrane transporter activity
GO:0015414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate-transporting ATPase activity
GO:0015414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate transmembrane-transporting ATPase activity
GO:0015414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate ABC transporter
REACT:R-XTR-9667563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR2 bind desmopressin (Xenopus tropicalis)
RHEA:31717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:22660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP + holo-[ACP] = a fatty acyl-[ACP] + AMP + diphosphate
REACT:R-GGA-3000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BORA binds SCF-beta-TrCp1/2 (Gallus gallus)
REACT:R-XTR-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Xenopus tropicalis)
REACT:R-SSC-73739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)
EC:6.3.2.10	skos:altLabel	"UDPacetylmuramoylpentapeptide synthetase"
EC:6.3.2.10	skos:altLabel	"uridine diphosphoacetylmuramoylpentapeptide synthetase"
EC:6.3.2.10	skos:altLabel	"UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase"
EC:6.3.2.10	skos:altLabel	"MurF synthetase"
EC:6.3.2.10	skos:altLabel	"UDP-MurNAc-pentapeptide synthetase"
EC:6.3.2.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase"
EC:6.3.2.10	skos:altLabel	"UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase"
EC:6.3.2.10	skos:altLabel	"UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase"
EC:6.3.2.10	skos:altLabel	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase"
EC:6.3.2.10	skos:altLabel	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase"
EC:6.3.2.10	skos:prefLabel	"UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase"
EC:6.3.2.10	skos:altLabel	"UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase"
RHEA:50990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin F2alpha(in) => prostaglandin F2alpha(out)
REACT:R-DRE-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Danio rerio)
REACT:R-MMU-977605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H displaces Bb (Mus musculus)
REACT:R-SSC-1980125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH binds DTX (Sus scrofa)
REACT:R-DME-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Drosophila melanogaster)
RHEA:45768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-L-alaninol + H2O = L-alaninol + L-glutamate
REACT:R-BTA-392054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Bos taurus)
REACT:R-HSA-9769345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated glucocorticoid receptor represses NPAS4 gene transcription (Homo sapiens)
REACT:R-SPO-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Schizosaccharomyces pombe)
RHEA:12007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoxyl + UDP-alpha-D-glucose <=> H(+) + indican + UDP
REACT:R-BTA-9756138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)
REACT:R-CEL-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Caenorhabditis elegans)
RHEA:39336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)
REACT:R-CFA-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Canis familiaris)
RHEA:44869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol => 1,2-diacyl-sn-glycero-3-phosphoethanol + choline
RHEA:25359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]
RHEA:25359	skos:prefLabel	"phycoerythrobilin synthase"
RHEA:25359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phycoerythrobilin synthase"
REACT:R-HSA-9610627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane (Homo sapiens)
RHEA:54977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanoyl-CoA + H2O => (3S)-hydroxytetradecanoate + CoA + H(+)
REACT:R-CFA-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Canis familiaris)
RHEA:53007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-MMU-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Mus musculus)
RHEA:30105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate + NAD(+) => 2,5-didehydro-D-gluconate + H(+) + NADH
GO:0018697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonyl sulfide nitrogenase activity
GO:0018697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonyl sulphide nitrogenase activity
RHEA:66460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O = 14betaH-scalarane-17alpha-19-diol
RHEA:44631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dihydroanticapsin + NAD(+) <=> H(+) + L-anticapsin + NADH
REACT:R-SPO-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Schizosaccharomyces pombe)
RHEA:54640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate = (12E)-labda-8(17),12,14-triene + diphosphate
RHEA:54640	skos:prefLabel	"(12E)-labda-8(17),12,14-triene synthase"
RHEA:54640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(12E)-labda-8(17),12,14-triene synthase"
REACT:R-HSA-2029455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIA with IgG-coated Ag (Homo sapiens)
REACT:R-DME-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Drosophila melanogaster)
REACT:R-MMU-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Mus musculus)
RHEA:38680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sphinganine(in) => ADP + H(+) + phosphate + sphinganine(out)
REACT:R-DDI-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Dictyostelium discoideum)
REACT:R-DRE-427337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBD2 binds methylcytosine in chromatin (Danio rerio)
REACT:R-GGA-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)
RHEA:27809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + acetyl-CoA <=> acetate + acetoacetyl-CoA
REACT:R-SSC-8982640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Sus scrofa)
REACT:R-SSC-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Sus scrofa)
REACT:R-HSA-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Homo sapiens)
RHEA:55184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylundecanoyl-CoA + O2 = 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate
GO:0018767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity
REACT:R-XTR-977602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to MCP, CR1:C4b, C3b (Xenopus tropicalis)
RHEA:31795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(E)-beta-caryophyllene + H2O = (+)-caryolan-1-ol
RHEA:31795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-caryolan-1-ol synthase"
RHEA:31795	skos:prefLabel	"(+)-caryolan-1-ol synthase"
RHEA:37095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA
RHEA:52095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)
REACT:R-RNO-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Rattus norvegicus)
REACT:R-SPO-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)
RHEA:38613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic ADP-beta-D-ribose + H(+) + nicotinamide => NAD(+)
REACT:R-BTA-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Bos taurus)
RHEA:12791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldose + H(+) + NADPH => an alditol + NADP(+)
RHEA:19222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 formaldehyde + H2O => formate + H(+) + methanol
REACT:R-XTR-8936608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)
RHEA:60853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine
RHEA:57617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-ML-236C-[compactin nonaketide synthase] + H2O => dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]
RHEA:27614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate = di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate
REACT:R-XTR-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-BTA-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Bos taurus)
RHEA:10691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + streptomycin 6-phosphate <=> phosphate + streptomycin
RHEA:43681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:64641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => lactose + N-acetylneuraminate
RHEA:39130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH
RHEA:63521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopropylphenol + H(+) + NADH + O2 => 3-isopropylcatechol + H2O + NAD(+)
RHEA:47813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)
RHEA:22462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-dehydroacyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)
GO:0001646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP receptor activity
GO:0001646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cAMP receptor activity
GO:0001646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic AMP receptor activity
GO:0001646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5' cAMP receptor activity
GO:0001646	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class E GPCR
GO:0001646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-cyclophosphate receptor activity
GO:0001646	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class E G-protein coupled receptor
GO:0001646	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class E G protein coupled receptor
REACT:R-HSA-1989778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ACSL1 (Homo sapiens)
RHEA:43792	skos:altLabel	"25S rRNA m(1)A(645) methyltransferase"
RHEA:43792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(645) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine
RHEA:43792	skos:prefLabel	"25S rRNA (adenine(645)-N(1))-methyltransferase"
RHEA:43792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"25S rRNA (adenine(645)-N(1))-methyltransferase"
RHEA:31087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + octanoyl-CoA = 3-oxodecanoyl-CoA + CoA
REACT:R-CFA-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Canis familiaris)
REACT:R-DDI-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Dictyostelium discoideum)
REACT:R-GGA-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Gallus gallus)
REACT:R-MMU-6814096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds SCOC (Mus musculus)
RHEA:25167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + butanoyl-CoA <=> (2E)-butenoyl-CoA + AH2
RHEA:64104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] = 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]
REACT:R-BTA-9615249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBs bind AGRT1 (Bos taurus)
RHEA:37097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA
RHEA:11931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylamine + NH4(+) <=> H(+) + H2O + hydrazine
REACT:R-HSA-8935960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the TJP1 (ZO-1) gene promoter (Homo sapiens)
RHEA:29657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(out) => L-cysteine(in)
REACT:R-SSC-2129362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin microfibril assembly (Sus scrofa)
RHEA:34032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-N-acetylparomamine + H2O => acetate + paromamine
RHEA:63773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
REACT:R-HSA-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Homo sapiens)
REACT:R-GGA-8964274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12) binds BTK (Gallus gallus)
REACT:R-SPO-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Schizosaccharomyces pombe)
RHEA:19440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate + UDP-alpha-D-glucose <=> N-(beta-D-glucosyl)nicotinate + UDP
REACT:R-RNO-6805546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I binds keratin type II (Rattus norvegicus)
RHEA:41116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine
RHEA:26374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + prostamide F2alpha => [thioredoxin]-dithiol + prostamide H2
REACT:R-DME-3249378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING recruits TBK1 and STAT6 (Drosophila melanogaster)
RHEA:55341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol => 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-HSA-3858387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated STAT3 positively regulates CEBPB transcription (Homo sapiens)
RHEA:41906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-[ACP] + NADP(+) => 3-oxohexadecanoyl-[ACP] + H(+) + NADPH
REACT:R-DME-214410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monomeric PGN binds to PGRP-LE in the cytosol (Drosophila melanogaster)
REACT:R-DME-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Drosophila melanogaster)
RHEA:38472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine + 3 S-adenosyl-L-methionine => 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine
REACT:R-HSA-9026003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Homo sapiens)
RHEA:24874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-D-serine => D-serine + phosphate
RHEA:13359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H(+) + NADH => 3-hydroxypropanoate + NAD(+)
RHEA:52699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP
REACT:R-RNO-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Rattus norvegicus)
GO:0090600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3-glucosidase activity
REACT:R-CFA-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Canis familiaris)
RHEA:55969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-kolavelool + S-adenosyl-L-methionine => (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine
RHEA:42753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine
GO:0034256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chl b reductase activity
GO:0034256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll(ide) b reductase activity
GO:0034256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide b reductase activity
GO:0034256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll b reductase activity
REACT:R-HSA-419197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
REACT:R-PFA-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Plasmodium falciparum)
RHEA:18123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thiol + NH4(+) + pyruvate => an S-substituted L-cysteine + H2O
GO:0106422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal
GO:0106422	skos:prefLabel	"carotenoid isomerooxygenase"
GO:0106422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carotenoid isomerooxygenase"
GO:0106422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carotenoid isomerooxygenase activity
RHEA:57383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hispidin + NADPH + O2 = 3-hydroxyhispidin + H2O + NADP(+)
REACT:R-DRE-5672027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Danio rerio)
REACT:R-CFA-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Canis familiaris)
RHEA:18999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-choline + diphosphate => CTP + H(+) + phosphocholine
REACT:R-MMU-1236956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfment of particulate antigen into phagocytic vesicle (Mus musculus)
RHEA:49930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:22863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + nicotinate beta-D-ribonucleotide <=> deamido-NAD(+) + diphosphate
REACT:R-HSA-6789042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroxyl-initiated lipid peroxidation (Homo sapiens)
RHEA:30370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)alamin 5'-phosphate + H2O <=> adenosylcob(III)alamin + phosphate
GO:0018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxide hydrolase A activity
REACT:R-CFA-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Canis familiaris)
RHEA:40717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + CoA => dihydroxyacetone phosphate + hexadecanoyl-CoA
GO:0003693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-element binding
REACT:R-HSA-168272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the influenza virion to the host cell (Homo sapiens)
REACT:R-DRE-2076392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcA to heparan (Danio rerio)
RHEA:25663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => alpha-pinene + diphosphate
REACT:R-RNO-2730884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of NTAL by p-SYK/Lyn (Rattus norvegicus)
REACT:R-HSA-8873923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 binds LPCAT1 and PC (Homo sapiens)
GO:0140581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type monovalent copper transporter activity
GO:0102704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity
REACT:R-RNO-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Rattus norvegicus)
RHEA:40414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)
REACT:R-GGA-438019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)
RHEA:18115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + ADP => a ribonucleoside 5'-diphosphate + ATP
RHEA:47228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:37858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA <=> 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-8873850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD5 binds DCA, LCA (Canis familiaris)
REACT:R-HSA-2730847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP2 by PLCG (Homo sapiens)
RHEA:32591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O = (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)
REACT:R-RNO-5682769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI2 binds ADAM22,23 (Rattus norvegicus)
REACT:R-CFA-6805507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 binds AVEN (Canis familiaris)
RHEA:15243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate
GO:0044620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP phosphopantetheine attachment site binding
RHEA:28359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + FADH2
GO:0018774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HOHPDA hydrolase activity
GO:0018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity
GO:0018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity
GO:0018774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity
RHEA:69357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hypobromite + L-tyrosyl-[protein] => 3-bromo-L-tyrosyl-[protein] + H2O
REACT:R-RNO-8849102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRMS phosphorylates PTK6 (Rattus norvegicus)
REACT:R-DME-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Drosophila melanogaster)
REACT:R-RNO-6807229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)
REACT:R-HSA-9697018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of sialic acids on some Spike glycosyl sidechains (Homo sapiens)
REACT:R-DRE-2424480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
REACT:R-DME-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Drosophila melanogaster)
GO:0005488	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ligand
GO:0005488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	binding
REACT:R-BTA-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Bos taurus)
REACT:R-RNO-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Rattus norvegicus)
REACT:R-XTR-9700701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T-type VDCC bind T-type VDCC blockers (Xenopus tropicalis)
RHEA:17980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + H2O + 2 NAD(+) <=> a long-chain fatty acid + 3 H(+) + 2 NADH
REACT:R-CFA-83582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Canis familiaris)
REACT:R-CFA-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Canis familiaris)
REACT:R-MMU-8851890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates SHC1-2 (Mus musculus)
REACT:R-RNO-9022314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates MECP2 (Rattus norvegicus)
RHEA:60150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate
RHEA:21618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate
RHEA:65126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl acetate + CoA => benzoyl-CoA + ethanol
REACT:R-MMU-9634584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Mus musculus)
GO:0097253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxybutyrate transmembrane transporter activity
GO:0097253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutanoic acid transmembrane transporter activity
GO:0097253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutyrate transmembrane transporter activity
RHEA:65014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + decanoyl-[ACP] + H(+) => decanoyl-AMP + holo-[ACP]
REACT:R-CFA-6788855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3KRP phosphorylates PsiAm, RibAm (Canis familiaris)
REACT:R-GGA-5687640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Gallus gallus)
REACT:R-HSA-9036041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS (Homo sapiens)
REACT:R-DRE-4720446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Danio rerio)
RHEA:20150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + quinine + reduced [NADPH--hemoprotein reductase] => 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5654569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS2 (Sus scrofa)
REACT:R-SSC-1250383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Sus scrofa)
EC:3.4.22.68	skos:altLabel	"Ulp1 endopeptidase"
EC:3.4.22.68	skos:altLabel	"Ubl-specific protease 1"
EC:3.4.22.68	skos:altLabel	"Smt3-protein conjugate proteinase"
EC:3.4.22.68	skos:prefLabel	"Ulp1 peptidase"
EC:3.4.22.68	skos:altLabel	"Ulp1"
EC:3.4.22.68	skos:altLabel	"Ulp1 protease"
EC:3.4.22.68	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Ulp1 peptidase"
RHEA:33788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-ketolactose + H2O => 3-keto-beta-D-galactose + beta-D-glucose
RHEA:13835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + L-alanine => L-arginine + pyruvate
REACT:R-BTA-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Bos taurus)
REACT:R-DRE-4641256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated AXIN is degraded by the proteasome (Danio rerio)
REACT:R-DME-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Drosophila melanogaster)
REACT:R-DME-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Drosophila melanogaster)
REACT:R-BTA-193965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 18HCORST to ALDO (Bos taurus)
RHEA:22859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-salutaridinol + acetyl-CoA <=> (7S)-O-acetylsalutaridinol + CoA
REACT:R-CFA-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Canis familiaris)
REACT:R-CEL-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Caenorhabditis elegans)
REACT:R-CFA-5689861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of XPA and release of CAK  (Canis familiaris)
REACT:R-GGA-9700154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds SHC1 (Gallus gallus)
REACT:R-RNO-8950398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX dissociates from IL27:EBI3 (Rattus norvegicus)
REACT:R-CEL-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)
RHEA:38015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol
REACT:R-BTA-381487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP1 binds IGF forming IGF:IGFBP1 (Bos taurus)
RHEA:53571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:21590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH => N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate
REACT:R-DDI-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Dictyostelium discoideum)
REACT:R-DME-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Drosophila melanogaster)
REACT:R-CEL-5419281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRRF binds 55S ribosome:mRNA:tRNA (Caenorhabditis elegans)
REACT:R-SSC-5683405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP5C dephosphorylates TP53BP1 (Sus scrofa)
REACT:R-SSC-6807565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY is transferred to the phagosome (Sus scrofa)
RHEA:40594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanedioyl-CoA + H2O <=> CoA + decanedioate + H(+)
RHEA:69149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermine => H2O2 + NH4(+) + spermine monoaldehyde
REACT:R-XTR-4085087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Xenopus tropicalis)
GO:0035639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine ribonucleoside triphosphate binding
GO:0035639	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	purine NTP binding
REACT:R-HSA-3364042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
REACT:R-MMU-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Mus musculus)
RHEA:59879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoate + ATP + L-cysteine <=> (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)
REACT:R-CFA-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Canis familiaris)
REACT:R-CEL-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Caenorhabditis elegans)
REACT:R-HSA-8864361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD15 binds TFAP2 homo- and heterodimers (Homo sapiens)
RHEA:18161	skos:altLabel	"3-oxopalmitoyl-CoA hydrolase"
RHEA:18161	skos:prefLabel	"acetyl-CoA C-myristoyltransferase"
RHEA:18161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetyl-CoA C-myristoyltransferase"
RHEA:18161	skos:altLabel	"3-oxopalmitoyl-CoA-CoA acetyltransferase"
RHEA:18161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA
RHEA:18161	skos:altLabel	"myristoyl-CoA C-acetyltransferase"
RHEA:68453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-10'-apo-beta-carotenal + O2 => 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone
REACT:R-CEL-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)
REACT:R-HSA-5663246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RORA, EP300 bind NPAS2 gene (Homo sapiens)
REACT:R-CFA-1592387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin binds elastic fibres (Canis familiaris)
GO:0036440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate synthase activity
RHEA:17987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate + 2 H(+) + NADH => 4-(trimethylamino)butanal + H2O + NAD(+)
GO:0031798	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 metabotropic glutamate receptor ligand
GO:0031798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 metabotropic glutamate receptor binding
REACT:R-SSC-202203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PI3K to plasma membrane (Sus scrofa)
REACT:R-CFA-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Canis familiaris)
REACT:R-DRE-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)
RHEA:56736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + retinal = H(+) + H2O2 + retinoate
RHEA:40270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH
REACT:R-RNO-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Rattus norvegicus)
RHEA:59674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotriono-1,5-lactone + H2O2 => D-maltotriose + O2
REACT:R-SSC-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Sus scrofa)
REACT:R-BTA-9649108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer binds 5HT (Bos taurus)
RHEA:31317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-D-glucose
REACT:R-HSA-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Homo sapiens)
RHEA:50992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thromboxane B2(out) = thromboxane B2(in)
RHEA:10669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)
REACT:R-SPO-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Schizosaccharomyces pombe)
REACT:R-GGA-420173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR1,CRHR2-1 binds CRH,UCN (Gallus gallus)
REACT:R-GGA-5654729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Gallus gallus)
REACT:R-SPO-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-CFA-212222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 recruits DNA methyltransferases (Canis familiaris)
REACT:R-CEL-5627071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Caenorhabditis elegans)
REACT:R-RNO-5686074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Rattus norvegicus)
REACT:R-CFA-9034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 dimers trans-autophosphorylate (Canis familiaris)
RHEA:64253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycine
REACT:R-XTR-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Xenopus tropicalis)
REACT:R-HSA-8961934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 (Homo sapiens)
RHEA:62524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine
REACT:R-HSA-4331324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds BBC3 (PUMA) promoter (Homo sapiens)
REACT:R-DME-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Drosophila melanogaster)
REACT:R-PFA-5690157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP16,USP21 deubiquitinate Histone H2A (Plasmodium falciparum)
REACT:R-BTA-8950398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX dissociates from IL27:EBI3 (Bos taurus)
RHEA:15202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymellein + S-adenosyl-L-methionine => 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine
RHEA:37331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionyl-L-alanine = L-alanine + L-methionine
REACT:R-CFA-8857925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Canis familiaris)
REACT:R-HSA-8985812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK2 binds to ROBO1,(ROBO2) (Homo sapiens)
RHEA:58221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + NAD(+) => H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide
RHEA:67605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-methyl-dATP => diphosphate + H(+) + N(6)-methyl-dAMP
REACT:R-MMU-446372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  PARVA with TESK1 (Mus musculus)
RHEA:60406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O
EC:2.4.1.26	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA alpha-glucosyltransferase"
EC:2.4.1.26	skos:prefLabel	"DNA alpha-glucosyltransferase"
RHEA:57719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate + NH4(+) <=> carbamate + H(+) + H2O
REACT:R-DRE-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Danio rerio)
RHEA:33765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + NADP(+) => a (2E)-enoyl-CoA + H(+) + NADPH
REACT:R-CEL-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Caenorhabditis elegans)
RHEA:43408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP
REACT:R-CFA-202714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD58 binds CD2 (Canis familiaris)
RHEA:38090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
RHEA:43392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 1,3-bisphosphate + phosphate
RHEA:19950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate => 7,8-dihydropteroate + diphosphate
REACT:R-GGA-9678935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Gallus gallus)
REACT:R-CFA-9008054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RAPL1 (Canis familiaris)
RHEA:69788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminophenyl)succinate + succinyl-CoA => 3-(2-aminophenyl)succinyl-CoA + succinate
REACT:R-XTR-2428926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Xenopus tropicalis)
REACT:R-HSA-8987084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Homo sapiens)
REACT:R-XTR-397835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:Gq (active) dissociate (Xenopus tropicalis)
RHEA:39584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)
REACT:R-GGA-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Gallus gallus)
RHEA:68566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin => 6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-216082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaXbeta2 with fibrin (Homo sapiens)
REACT:R-HSA-389532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A binds CTLA4 dimer (Homo sapiens)
REACT:R-XTR-114552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate G12/13 (Xenopus tropicalis)
REACT:R-HSA-8943003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH polyubiquitinates monoubiquitinated PCNA (Homo sapiens)
GO:0047644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity
GO:0047644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-alizarin glucosyltransferase activity
GO:0047644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity
GO:0047644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alizarin 2-beta-glucosyltransferase activity
GO:0047644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alizarin 2-b-glucosyltransferase activity
REACT:R-BTA-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Bos taurus)
REACT:R-HSA-1980048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLL1 binds NOTCH2 (Homo sapiens)
REACT:R-CFA-432909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Plectin with Integrin beta 4 (Canis familiaris)
REACT:R-GGA-2161195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Gallus gallus)
REACT:R-DRE-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Danio rerio)
REACT:R-DRE-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Danio rerio)
REACT:R-GGA-5624486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylates RAF1 on Y340,Y341 (Gallus gallus)
REACT:R-GGA-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Gallus gallus)
REACT:R-DRE-9025996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Danio rerio)
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-L-isoaspartate(D-aspartate) O-methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein beta-aspartate O-methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein (D-aspartate) methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein L-isoaspartate methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein L-isoaspartyl methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartyl/L-isoaspartyl protein methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-beta-aspartate O-methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein O-methyltransferase (L-isoaspartate)
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-L-isoaspartate O-methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein D-aspartate methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aspartyl/L-isoaspartyl methyltransferase activity
GO:0004719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-isoaspartyl protein carboxyl methyltransferase activity
RHEA:30826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
REACT:R-SSC-1237047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ hydrates CO2 to HCO3- (Sus scrofa)
REACT:R-RNO-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Rattus norvegicus)
EC:1.14.19.63	skos:prefLabel	"pseudobaptigenin synthase"
EC:1.14.19.63	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudobaptigenin synthase"
REACT:R-BTA-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Bos taurus)
REACT:R-GGA-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Gallus gallus)
REACT:R-SPO-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Schizosaccharomyces pombe)
REACT:R-BTA-5684081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds CDK2 and RBBP8 (Bos taurus)
RHEA:48037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + H2O => globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine
REACT:R-DRE-8855747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Danio rerio)
RHEA:44032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxy-(12Z)-octadecenoate + H2O = 9,10-dihydroxy-(12Z)-octadecenoate
REACT:R-HSA-381461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)
RHEA:57917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartyl-tRNA(Asn) => 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)
REACT:R-SCE-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Saccharomyces cerevisiae)
GO:0051747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA methyltransferase activity acting on cytosine C-5
GO:0051747	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrolytic DNA demethylase activity
GO:0051747	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA demethylase activity
GO:0051747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine C-5 DNA demethylase activity
RHEA:63919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-fluorouridine + ATP <=> 5-fluorouridine 5'-phosphate + ADP + H(+)
REACT:R-RNO-9709842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS binds TOMM70 (Rattus norvegicus)
RHEA:54350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline
REACT:R-SSC-202960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of C-IAP1 (Sus scrofa)
RHEA:71087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)
RHEA:34628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]
REACT:R-CFA-517536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Canis familiaris)
RHEA:37972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)
REACT:R-CEL-4570554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO1 (Caenorhabditis elegans)
RHEA:20345	skos:prefLabel	"thioredoxin-disulfide reductase"
RHEA:20345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thioredoxin-disulfide reductase"
RHEA:20345	skos:altLabel	"NADPH--thioredoxin reductase"
RHEA:20345	skos:altLabel	"thioredoxin reductase (NADPH)"
RHEA:20345	skos:altLabel	"NADPH:oxidized thioredoxin oxidoreductase"
RHEA:20345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH
RHEA:20345	skos:altLabel	"NADP--thioredoxin reductase"
RHEA:48279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine
RHEA:38245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-eicosanyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + eicosan-1-ol
REACT:R-RNO-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Rattus norvegicus)
REACT:R-CFA-3318413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Canis familiaris)
RHEA:67682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + CoA + H(+) => a long-chain fatty acyl-CoA + H2O
REACT:R-RNO-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Rattus norvegicus)
REACT:R-SPO-6800490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates PIDD1 (Schizosaccharomyces pombe)
REACT:R-RNO-5250947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH complex binds rDNA promoter (Rattus norvegicus)
RHEA:62442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1) => [(1->4)-alpha-D-galacturonosyl methyl ester](n)
REACT:R-CFA-374251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARC  is a non-specific receptor for many chemokines (Canis familiaris)
RHEA:23953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetate
REACT:R-RNO-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Rattus norvegicus)
REACT:R-HSA-6800044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates IGFBP3 expression (Homo sapiens)
REACT:R-GGA-9614423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO1 (Gallus gallus)
GO:0090438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming)
GO:0090438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	camelliol C synthase activity
RHEA:52021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => A + H2O + resolvin E2
RHEA:55098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxypentanoate + CoA + H(+) => (3S)-3-hydroxypentanoyl-CoA + H2O
REACT:R-MMU-2465890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR2 binds collagen type I, II, III, V, X fibrils (Mus musculus)
REACT:R-MMU-5654705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
RHEA:39408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-acetylgalactosamine pyrophosphorylase activity
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase activity
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine diphosphate-N-acetylgalactosamine pyrophosphorylase activity
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-GalNAc pyrophosphorylase activity
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine 1-phosphate uridylyltransferase
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine diphosphoacetylgalactosamine phosphorylase activity
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine diphosphoacetylgalactosamine pyrophosphorylase activity
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP:2-acetamido-2-deoxy-alpha-D-galactose-1-phosphate uridylyltransferase activity
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine-1-phosphate uridyltransferase activity
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylgalactosamine pyrophosphorylase activity
GO:0052630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylgalactosamine diphosphorylase activity
RHEA:38456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
RHEA:62506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein]
REACT:R-HSA-5694431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Homo sapiens)
RHEA:48745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-yatein + 2-oxoglutarate + O2 => (-)-deoxypodophyllotoxin + CO2 + H2O + succinate
REACT:R-XTR-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Xenopus tropicalis)
RHEA:34030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH
RHEA:52585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH
RHEA:44701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + FAD + H(+) => a (2E)-enoyl-CoA + FADH2
REACT:R-CFA-9669893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type I TKIs (Canis familiaris)
RHEA:64328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA
REACT:R-DME-6805479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53RK phosphorylates TP53 (Drosophila melanogaster)
REACT:R-RNO-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Rattus norvegicus)
RHEA:22484	skos:altLabel	"Ap4Aase"
RHEA:22484	skos:prefLabel	"bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)"
RHEA:22484	skos:altLabel	"bis(5'-guanosyl)-tetraphosphatase"
RHEA:22484	skos:altLabel	"dinucleosidetetraphosphatase (asymmetrical)"
RHEA:22484	skos:altLabel	"diguanosinetetraphosphatase (asymmetrical)"
RHEA:22484	skos:altLabel	"diadenosinetetraphosphatase (asymmetrical)"
RHEA:22484	skos:altLabel	"bis(5'-adenosyl)-tetraphosphatase"
RHEA:22484	skos:altLabel	"Ap4A hydrolase"
RHEA:22484	skos:altLabel	"diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase"
RHEA:22484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)"
RHEA:22484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = GMP + GTP + 2 H(+)
GO:0031774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene receptor binding
GO:0031774	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leukotriene receptor ligand
RHEA:24503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-tetraphosphate + H2O <=> ATP + H(+) + phosphate
REACT:R-XTR-190782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of connexon-containing transport vesicles from the Golgi (Xenopus tropicalis)
REACT:R-DME-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Drosophila melanogaster)
RHEA:30412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + benzyl alcohol => benzyl benzoate + CoA
RHEA:17654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
REACT:R-GGA-388828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PD-1 binds B7DC and B7H1 (Gallus gallus)
RHEA:20196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + NADP(+) <=> H(+) + mevaldate + NADPH
REACT:R-MMU-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Mus musculus)
RHEA:19475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + H2O + NAD(+) => 4-hydroxybenzoate + H(+) + NADH + O2
REACT:R-MMU-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Mus musculus)
RHEA:56036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)
REACT:R-DRE-2534240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) degradation by MMP14, MMP15 (Danio rerio)
RHEA:22057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + NAD(+) => H(+) + hexadecanal + NADH
REACT:R-MMU-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Mus musculus)
REACT:R-MMU-1889955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT dimers transfer GlcA to tetrasaccharide linker (Mus musculus)
RHEA:61422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-cis-nepetalactol => (S)-8-oxocitronellyl enol
REACT:R-RNO-975122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Rattus norvegicus)
RHEA:64731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate
RHEA:42766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + reduced coenzyme F420-(gamma-L-Glu)(n) => formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)
GO:0008726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMNH(2)-dependent aliphatic sulfonate monooxygenase activity
GO:0008726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMNH2-dependent aliphatic sulfonate monooxygenase activity
GO:0008726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity
GO:0008726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkanesulfonate monooxygenase activity
GO:0008726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfate starvation-induced protein 6 activity
GO:0008726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SsuD
GO:0008726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH(2)-dependent alkanesulfonate monooxygenase activity
GO:0008726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkanesulphonate monooxygenase activity
RHEA:11983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 gamma-L-glutamyl-L-cysteine + NADP(+) <=> bis-gamma-glutamylcystine + H(+) + NADPH
RHEA:19109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-glucogallin--tetrakisgalloylglucose O-galloyltransferase"
RHEA:19109	skos:prefLabel	"beta-glucogallin--tetrakisgalloylglucose O-galloyltransferase"
RHEA:19109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)
RHEA:69286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 17-oxo steroid + H(+) + NADPH => a 17beta-hydroxy steroid + NADP(+)
RHEA:72094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + Na(+)(out) <=> (R)-carnitine(in) + Na(+)(in)
REACT:R-MMU-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)
RHEA:40657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malyl-CoA + succinate => (R)-malate + succinyl-CoA
RHEA:40196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-HSA-5610038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GALT does not transfer UMP to Gal1P (Homo sapiens)
RHEA:32596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-isopropyl-4-methyloxepan-2-one + H2O => 6-hydroxy-3,7-dimethyloctanoate + H(+)
REACT:R-RNO-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Rattus norvegicus)
GO:0102633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flaviolin monooxygenase activity
REACT:R-DME-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Drosophila melanogaster)
REACT:R-HSA-5660660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p300 acetylates RELA subunit (Homo sapiens)
RHEA:19410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NAD(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH
RHEA:15056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide
RHEA:69466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine
REACT:R-XTR-417858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y14 receptor can bind to UDP-glucose (Xenopus tropicalis)
REACT:R-MMU-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Mus musculus)
RHEA:55080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + D-fructose = ADP + H(+) + sucrose
REACT:R-BTA-193711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
GO:2001079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding
RHEA:44924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + acetyl-CoA + H2O = (R)-dihomocitrate + CoA + H(+)
GO:0018513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene dihydrodiol dehydrogenase activity
GO:0018513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PNL activity
GO:0047490	skos:altLabel	"pectin methyltranseliminase"
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PMGL activity
GO:0047490	skos:altLabel	"PNL"
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectin methyltranseliminase activity
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pectin trans-eliminase activity
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pectin lyase activity
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polymethylgalacturonic transeliminase activity
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity
GO:0047490	skos:altLabel	"PL"
GO:0047490	skos:altLabel	"polymethylgalacturonic transeliminase"
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectolyase activity
GO:0047490	skos:altLabel	"pectolyase"
GO:0047490	skos:altLabel	"pectin trans-eliminase"
GO:0047490	skos:altLabel	"PMGL"
GO:0047490	skos:altLabel	"endo-pectin lyase"
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pectin lyase"
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-pectin lyase activity
GO:0047490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PL activity
GO:0047490	skos:prefLabel	"pectin lyase"
REACT:R-XTR-265425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with von Willbrand Factor (Xenopus tropicalis)
RHEA:45259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate(out) <=> hexadecanoate(in)
RHEA:39358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)
RHEA:59875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP
RHEA:22658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + L-serine-phosphoethanolamine => CDP-ethanolamine + L-serine
REACT:R-DRE-9708466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y486 BACH1 translocates from the nucleoplasm to the cytosol (Danio rerio)
REACT:R-MMU-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Mus musculus)
REACT:R-GGA-5357479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AXL binds PI3K (Gallus gallus)
RHEA:53812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-6799695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX5,6 reduce H2O2 to H2O (Rattus norvegicus)
REACT:R-CFA-8937767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 dephosphorylates RUNX1 (Canis familiaris)
RHEA:31753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)
REACT:R-BTA-109539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Bos taurus)
REACT:R-GGA-3247493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO1 (Gallus gallus)
REACT:R-MMU-2022919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Mus musculus)
REACT:R-DRE-380949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK is dephosphorylated (Danio rerio)
RHEA:69014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-androstane-3beta,17beta-diol + NADP(+) => 5beta-dihydrotestosterone + H(+) + NADPH
RHEA:69214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate
REACT:R-CFA-8983996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Canis familiaris)
REACT:R-GGA-9620515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2B,EP300 acetylate FOXO3 under oxidative stress (Gallus gallus)
REACT:R-CFA-158609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers CH3 from AdoMet to 6MP (Canis familiaris)
RHEA:46746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + carboxyphosphate => ATP + hydrogencarbonate
RHEA:61711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-seryl-5'-AMP <=> AMP + L-seryl-[peptidyl-carrier protein]
GO:0033883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PNP phosphatase activity
GO:0033883	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	vitamin B6 (pyridoxine) phosphatase activity
GO:0033883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PLP phosphatase activity
GO:0033883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal-5'-phosphate phosphohydrolase activity
GO:0033883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal phosphatase activity
GO:0033883	skos:prefLabel	"pyridoxal phosphatase"
GO:0033883	skos:altLabel	"vitamin B6 (pyridoxine) phosphatase"
GO:0033883	skos:altLabel	"PNP phosphatase"
GO:0033883	skos:altLabel	"PLP phosphatase"
GO:0033883	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	vitamin B6-phosphate phosphatase activity
GO:0033883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxal phosphatase"
GO:0033883	skos:altLabel	"vitamin B6-phosphate phosphatase"
REACT:R-DME-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Drosophila melanogaster)
RHEA:48125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 (d18:1(4E)) + H2O => ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate
REACT:R-BTA-9714924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to soluble TNF trimer (Bos taurus)
RHEA:56155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:39548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O
RHEA:20551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate => 2 Fe(III)-[cytochrome c] + 2 thiosulfate
REACT:R-BTA-9013108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOC (Bos taurus)
REACT:R-HSA-9655071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcription of DDIT3 (CHOP, GADD153) in response to heme deficiency (Homo sapiens)
RHEA:50162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2
RHEA:43309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycerol + ATP => 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SSC-265301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticotropin cleavage from POMC (Sus scrofa)
REACT:R-DRE-8850992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated PTEN (Danio rerio)
REACT:R-DDI-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Dictyostelium discoideum)
REACT:R-XTR-4755536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates RELA with SUMO3 (Xenopus tropicalis)
RHEA:66216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-C7-CoA + O2 = asc-DeltaC7-CoA + H2O2
RHEA:59833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]
REACT:R-MMU-159783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)
REACT:R-CFA-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Canis familiaris)
REACT:R-HSA-5637801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	porphobilinogen deaminase activity
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uroporphyrinogen I synthetase activity
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HMB-synthase activity
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pre-uroporphyrinogen synthase activity
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen synthetase activity
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uroporphyrinogen I synthase activity
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen synthase activity
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	porphobilinogen ammonia-lyase (polymerizing)
GO:0004418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylbilane synthase activity
REACT:R-CEL-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Caenorhabditis elegans)
RHEA:71842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) <=> dehydroepiandrosterone 3-sulfate(in)
REACT:R-RNO-8878787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPI dimer hydrolyses phosphate monoesters (Rattus norvegicus)
REACT:R-HSA-9769249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 stimulates SYT10 gene expression (Homo sapiens)
RHEA:41348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
REACT:R-CEL-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Caenorhabditis elegans)
RHEA:63143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoyl-taurine <=> taurine + tetracosanoate
REACT:R-DRE-8864343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD1 binds TFAP2 homo- and heterodimers (Danio rerio)
RHEA:32635	skos:prefLabel	"linalool 8-monooxygenase"
RHEA:32635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:32635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linalool 8-monooxygenase"
RHEA:32635	skos:altLabel	"CYP111"
RHEA:40533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:62220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phyllostine = neopatulin
RHEA:53875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + D-ribose 5-phosphate + H(+) <=> CDP-D-ribose + diphosphate
RHEA:45822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylfumaryl-CoA + succinate => mesaconate + succinyl-CoA
RHEA:54124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine h dioxetanone = CO2 + excited coelenteramide h monoanion + H(+)
RHEA:50586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin E1 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+)
RHEA:50194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-alpha-D-xylose
REACT:R-RNO-2404193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1R phosphorylates SHC1 (Rattus norvegicus)
REACT:R-DRE-4827382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Danio rerio)
REACT:R-CFA-1602446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Canis familiaris)
REACT:R-XTR-9681763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1 binds IL1R1 inhibitors (Xenopus tropicalis)
REACT:R-HSA-8944225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVII (Homo sapiens)
REACT:R-SSC-9700662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Sus scrofa)
REACT:R-SPO-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)
REACT:R-SSC-445448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHIP binds Hedgehog (Sus scrofa)
REACT:R-XTR-5690701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 binds p-CD22 (Xenopus tropicalis)
REACT:R-GGA-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Gallus gallus)
REACT:R-RNO-8854736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 binds FLT3 (Rattus norvegicus)
REACT:R-RNO-4546387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VDR with SUMO2 (Rattus norvegicus)
REACT:R-HSA-9621386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIB1 gene expression (Homo sapiens)
REACT:R-XTR-5362549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np traffics to the plasma membrane (Xenopus tropicalis)
RHEA:52903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide <=> 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate
REACT:R-GGA-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Gallus gallus)
REACT:R-DDI-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Dictyostelium discoideum)
RHEA:52184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5686657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
REACT:R-CEL-9699579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of FLT3  (Caenorhabditis elegans)
RHEA:64355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA
REACT:R-BTA-8952903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRHL2 hydrolyses poly(ADP-ribose) (Bos taurus)
REACT:R-CEL-77331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Caenorhabditis elegans)
RHEA:51430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-N-acetamidomethylphosphonate + CoA => acetyl-CoA + aminomethylphosphonate
REACT:R-GGA-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Gallus gallus)
REACT:R-BTA-8985988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Bos taurus)
REACT:R-DRE-373342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3CR1 binds CX3CL1 (Danio rerio)
REACT:R-CFA-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Canis familiaris)
REACT:R-BTA-8863914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of SEC22B, TAP and PLC from ER to ERGIC (Bos taurus)
REACT:R-SSC-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Sus scrofa)
REACT:R-HSA-8952081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX proteins bind the p14-ARF promoter at the CDKN2A locus (Homo sapiens)
REACT:R-BTA-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Bos taurus)
REACT:R-SSC-912527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)
REACT:R-RNO-2046175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further sulfation on galactose residues produces KSPG (Rattus norvegicus)
REACT:R-CFA-8852716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin, ELANE cleave C5 (Canis familiaris)
REACT:R-SSC-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Sus scrofa)
RHEA:38154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonyl sulfide + H2O <=> CO2 + H(+) + hydrogen sulfide
REACT:R-HSA-5671763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates PPP1R14A (Homo sapiens)
GO:0070004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type exopeptidase activity
REACT:R-MMU-5693615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Mus musculus)
RHEA:55148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH
REACT:R-BTA-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
RHEA:56265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
REACT:R-RNO-111237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR1 homodimer (Rattus norvegicus)
REACT:R-MMU-4084903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types VI, IX bind integrin alpha10beta1 (Mus musculus)
RHEA:55577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine => H(+) + psilocybin + S-adenosyl-L-homocysteine
REACT:R-RNO-4719448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO3 (Rattus norvegicus)
RHEA:23525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol => an alkyl cinnamate + beta-D-glucose
RHEA:57627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:70022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + typhasterol <=> 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O
REACT:R-RNO-6799431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds HIPK1 (Rattus norvegicus)
GO:0050075	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-malate hydro-lyase activity
GO:0050075	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-malate hydro-lyase activity
GO:0050075	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-malate hydro-lyase (maleate-forming)
GO:0050075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleate hydratase activity
GO:0050075	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malease activity
REACT:R-CFA-109700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT2 binds PIP3 (Canis familiaris)
REACT:R-DME-190388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3c (Drosophila melanogaster)
GO:0009976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tocopherol cyclase activity
GO:0005122	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	torso ligand
GO:0005122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tor binding
GO:0005122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	torso binding
GO:0005122	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tor ligand
RHEA:43030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + H(+) + sulfite => L-cysteate
REACT:R-SSC-5685649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPAs translocate from ER membrane to extracellular region (Sus scrofa)
REACT:R-XTR-159425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
RHEA:66262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + IC-asc-C7-CoA => CoA + IC-asc-C7-AMP
REACT:R-HSA-77591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
REACT:R-SSC-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Sus scrofa)
RHEA:54369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H(+) + pyruvate => acetoin + CO2
REACT:R-SPO-9733403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds PCSK9 inhibitors (Schizosaccharomyces pombe)
REACT:R-BTA-1295599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 translocates to the plasma membrane (Bos taurus)
REACT:R-HSA-190385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3b (Homo sapiens)
REACT:R-RNO-449829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11 binds IL11RA (Rattus norvegicus)
REACT:R-MMU-5638157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Mus musculus)
REACT:R-RNO-204873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shp2 (Rattus norvegicus)
REACT:R-SPO-8851538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)
REACT:R-SPO-8869627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NR to yield NMN (Schizosaccharomyces pombe)
REACT:R-CEL-74247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)
RHEA:32592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O => (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)
RHEA:54567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)
RHEA:49010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C epoxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2
GO:0102170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-epi-aristolochene-1,3-dihydroxylase activity
REACT:R-BTA-8866329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP lipidates APOB-100, forming a pre-VLDL (Bos taurus)
REACT:R-CFA-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Canis familiaris)
REACT:R-DDI-6787540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUK phosphorylates beta-Fuc to Fuc1P (Dictyostelium discoideum)
REACT:R-MMU-5654612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)
REACT:R-XTR-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)
RHEA:53070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxyestrone + UDP-alpha-D-glucuronate
RHEA:27790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 = a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)
RHEA:27790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-octaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)
RHEA:27790	skos:prefLabel	"2-polyprenylphenol 6-hydroxylase"
RHEA:27790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-polyprenylphenol 6-hydroxylase"
RHEA:26132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)
RHEA:37399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
GO:0102355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity
REACT:R-CFA-141026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor Va to factor Vi intermediate form (Canis familiaris)
REACT:R-SSC-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Sus scrofa)
GO:0034525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthaldehyde dehydrogenase activity
GO:0106155	skos:prefLabel	"peptidyl-lysine (3S)-dioxygenase"
GO:0106155	skos:altLabel	"Jumonji domain-containing protein 7"
GO:0106155	skos:altLabel	"JmjC domain-containing protein 7"
GO:0106155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidyl-lysine (3S)-dioxygenase"
GO:0106155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-lysine 3-dioxygenase activity
GO:0106155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[protein] + O2 = (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate
REACT:R-MMU-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Mus musculus)
RHEA:20166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-acyl-L-ornithine ester => an alcohol + H(+) + N(5)-acyl-L-ornithine
RHEA:49380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Bos taurus)
RHEA:49191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d <=> a 3-vinylbacteriochlorophyllide d + H2O
REACT:R-CFA-9708104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE5A dimer binds PDE5A inhibitors (Canis familiaris)
RHEA:60419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diglucosyl-enterobactin + H2O <=> H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2
GO:0005457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)
GO:0005457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-fucose transmembrane transporter activity
GO:0005457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)
REACT:R-HSA-1181156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL (Homo sapiens)
REACT:R-CFA-5336182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37 binds prosaptide (Canis familiaris)
REACT:R-RNO-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Rattus norvegicus)
RHEA:13154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + CO2 + NAD(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH
RHEA:41077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-BTA-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Bos taurus)
REACT:R-BTA-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Bos taurus)
REACT:R-MMU-8849428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 binds PTK6 (Mus musculus)
REACT:R-DDI-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Dictyostelium discoideum)
REACT:R-CFA-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Canis familiaris)
REACT:R-HSA-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Homo sapiens)
RHEA:27491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate => 2 D-sedoheptulose 7-phosphate
REACT:R-CFA-2514772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Canis familiaris)
REACT:R-DME-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Drosophila melanogaster)
REACT:R-CEL-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Caenorhabditis elegans)
RHEA:59450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + H(+) + NADPH => dodecan-1-ol + NADP(+)
REACT:R-RNO-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Rattus norvegicus)
RHEA:12293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine + tRNA(Ser) => AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)
REACT:R-CFA-77283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Canis familiaris)
REACT:R-HSA-9644879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4:ARNT2 binds BDNF gene promoter (Homo sapiens)
REACT:R-CFA-193054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cholesterol to 22beta-hydroxycholesterol (Canis familiaris)
RHEA:45674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)
REACT:R-DME-209196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CI by PKA-C1 (Drosophila melanogaster)
RHEA:24206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sulfoacetaldehyde => acetyl phosphate + H(+) + sulfite
RHEA:29565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate
RHEA:40336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:67970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphate + presqualene monophosphate => H2O + presqualene diphosphate
RHEA:40435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine
REACT:R-DRE-379415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Danio rerio)
RHEA:45052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + (R)-carnitine = CoA + O-(2E)-butenoyl-(R)-carnitine
REACT:R-CEL-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Caenorhabditis elegans)
REACT:R-MMU-201639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of GAS2 (Mus musculus)
REACT:R-DRE-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
REACT:R-RNO-8942344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 transports FOLA from extracellular region to cytosol (Rattus norvegicus)
RHEA:55286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl tetradecanoate + CoA => all-trans-retinol + tetradecanoyl-CoA
REACT:R-HSA-5624130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylated NPHP3 translocates into the ciliary membrane (Homo sapiens)
REACT:R-CFA-444731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Canis familiaris)
RHEA:26024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8'-apo-beta-carotenol + O2 => (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal
REACT:R-DRE-6798373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates DYRK2 (Danio rerio)
RHEA:36830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioscin + 3 H2O <=> D-glucose + diosgenin + 2 L-rhamnopyranose
REACT:R-CFA-2730833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
REACT:R-RNO-8964614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Rattus norvegicus)
REACT:R-HSA-8865265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)
REACT:R-CFA-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Canis familiaris)
REACT:R-RNO-9632033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GalNAc to chondroitin (Rattus norvegicus)
RHEA:22965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-ornithine => CO2 + putrescine
REACT:R-RNO-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Rattus norvegicus)
RHEA:21659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-paratose <=> CDP-3,6-dideoxy-alpha-D-mannose
REACT:R-CFA-3301943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTK1 dimer transfers GS from GSH to CDNB (Canis familiaris)
REACT:R-XTR-2186607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
REACT:R-DRE-202709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 dimerises (Danio rerio)
REACT:R-CFA-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Canis familiaris)
REACT:R-MTU-936667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate binds to SubI outside the membrane (Mycobacterium tuberculosis)
REACT:R-DRE-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Danio rerio)
REACT:R-GGA-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Gallus gallus)
RHEA:49371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) <=> 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate
RHEA:60484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + UTP = cyclic CMP-UMP + 2 diphosphate
REACT:R-CFA-266303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds C and E apolipoproteins (Canis familiaris)
GO:0052793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pectin acetylesterase activity
REACT:R-BTA-9761344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 binds IKBKG within IKK complex (Bos taurus)
RHEA:27582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxymethylglutarate = 2-methyleneglutarate + H2O
RHEA:44427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + heptadecasphing-4-enine <=> CoA + H(+) + N-acyl-heptadecasphing-4-enine
RHEA:14095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + L-glutamate => 2-oxoglutarate + L-tryptophan
EC:3.4.17.22	skos:altLabel	"carboxypeptidase D"
EC:3.4.17.22	skos:prefLabel	"metallocarboxypeptidase D"
EC:3.4.17.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"metallocarboxypeptidase D"
RHEA:72706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose(in) + UMP(out) <=> UDP-alpha-D-galactose(out) + UMP(in)
REACT:R-CFA-5633051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFCAB7:IQCE binds EVC2:EVC (Canis familiaris)
REACT:R-DME-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Drosophila melanogaster)
REACT:R-SSC-376364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp8 associated secretory vesicle to plasma membrane transport (Sus scrofa)
REACT:R-HSA-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
REACT:R-BTA-1297275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD9:Izumo Binding (Bos taurus)
RHEA:46959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:56682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-XTR-8849908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM4 binds flotillin-1 (Xenopus tropicalis)
REACT:R-XTR-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Xenopus tropicalis)
REACT:R-GGA-8964599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Gallus gallus)
REACT:R-MMU-4090390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates AR with SUMO1 (Mus musculus)
REACT:R-SSC-9731393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA, EDNRB bind non-selective ERAs (Sus scrofa)
RHEA:46807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine <=> a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine
GO:0034710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inhibin complex binding
RHEA:34898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + selenite(out) <=> ADP + H(+) + phosphate + selenite(in)
REACT:R-RNO-5675194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPK phosphorylates RAF1 (Rattus norvegicus)
GO:0033699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA 5'-adenosine monophosphate hydrolase activity
GO:0033699	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA de-adenylation
GO:0033699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA 5'-adenylate hydrolase activity
GO:0033699	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA adenylate hydrolysis activity
GO:0033699	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA deadenylation
GO:0033699	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP-removal activity
RHEA:28212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate => H2O + L-saccharopine + O2
REACT:R-MMU-158893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Mus musculus)
REACT:R-DME-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Drosophila melanogaster)
REACT:R-CEL-377640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of SRC (Caenorhabditis elegans)
REACT:R-DRE-398185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG binds plexin B1 (Danio rerio)
RHEA:42396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"
RHEA:42396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:42396	skos:prefLabel	"tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"
RHEA:68069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:50629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-(omega-methylsulfanyl)alkylmalate => a 3-(omega-methylsulfanyl)alkylmalate
RHEA:13317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate + H(+) = (R)-glycerate + CO2
RHEA:13317	skos:prefLabel	"tartrate decarboxylase"
RHEA:13317	skos:altLabel	"(R,R)-tartrate carboxy-lyase"
RHEA:13317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tartrate decarboxylase"
REACT:R-CFA-5672972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
REACT:R-RNO-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)
REACT:R-SSC-444773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-TM7 receptors bind chondroitin sulphate (Sus scrofa)
REACT:R-CEL-114544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p115-RhoGEF activation of RHOA (Caenorhabditis elegans)
RHEA:65249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 5 H(+) + 5 malonyl-CoA => 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O
RHEA:59386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-aminophenyl)pyruvate + L-glutamate => 2-oxoglutarate + 4-amino-L-phenylalanine
REACT:R-HSA-5626549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind CALM1 (Homo sapiens)
REACT:R-SSC-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Sus scrofa)
RHEA:58440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine
REACT:R-MMU-193650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR binds to NADE (Mus musculus)
REACT:R-SSC-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Sus scrofa)
REACT:R-GGA-9700175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates SHC1 (Gallus gallus)
RHEA:55371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + H(+) + NADPH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine
RHEA:13591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate => 3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate
RHEA:18188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + O2 <=> 5'-dehydroadenosine + H2O2
REACT:R-HSA-9609743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Homo sapiens)
RHEA:45266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate(in) => (9Z,12Z)-octadecadienoate(out)
REACT:R-SSC-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Sus scrofa)
RHEA:26291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate => 2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine
REACT:R-SSC-158313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XII -> factor XIIa (Sus scrofa)
RHEA:56647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in mRNA <=> a pseudouridine in mRNA
RHEA:12292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)
REACT:R-MMU-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Mus musculus)
GO:0050366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyramine N-feruloyl-CoA transferase activity
GO:0050366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feruloyltyramine synthase activity
GO:0050366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + tyramine = CoA + H(+) + N-[(E)-feruloyl]tyramine
GO:0050366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyramine N-feruloyltransferase activity
GO:0050366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyramine feruloyltransferase activity
GO:0050366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyramine N-feruloyltransferase"
GO:0050366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feruloyl-CoA tyramine N-feruloyl-CoA transferase activity
GO:0050366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity
GO:0050366	skos:prefLabel	"tyramine N-feruloyltransferase"
RHEA:58950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine
RHEA:52852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] = 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]
RHEA:52852	skos:prefLabel	"pimeloyl-[acyl-carrier protein] synthase"
RHEA:52852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pimeloyl-[acyl-carrier protein] synthase"
RHEA:52852	skos:altLabel	"CYP107H1"
RHEA:48806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2
RHEA:38231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA
REACT:R-MMU-8953339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNPH1 hydrolyses dGMP (Mus musculus)
RHEA:64489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA => 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA
RHEA:26276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-3 + S-adenosyl-L-methionine <=> Co-precorrin-4 + S-adenosyl-L-homocysteine
RHEA:10924	skos:prefLabel	"2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase"
RHEA:10924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide
RHEA:10924	skos:altLabel	"2-chlorocarboxymethylenebutenolide isomerase"
RHEA:10924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase"
RHEA:10924	skos:altLabel	"chlorodienelactone isomerase"
REACT:R-MMU-5676591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Mus musculus)
REACT:R-SSC-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Sus scrofa)
REACT:R-XTR-2046089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Xenopus tropicalis)
REACT:R-SCE-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Saccharomyces cerevisiae)
RHEA:19658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH
RHEA:19232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + an aromatic aldehyde + diphosphate + NADP(+) <=> an aromatic carboxylate + ATP + H(+) + NADPH
RHEA:28927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)
RHEA:28927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gallate dioxygenase"
RHEA:28927	skos:prefLabel	"gallate dioxygenase"
RHEA:55162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:31108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + O2 => (2-hydroxyphenyl)acetate + CO2
REACT:R-GGA-419144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate (Gallus gallus)
REACT:R-DDI-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Dictyostelium discoideum)
REACT:R-XTR-549322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations out of hepatic cells (Xenopus tropicalis)
RHEA:39542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)
RHEA:23642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate => 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2
REACT:R-MMU-1912357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH ubiquitinates DTX (Mus musculus)
RHEA:69059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-methyl-L-arginine + NADH + O2 <=> H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)
RHEA:72935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in)
REACT:R-CFA-2465890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR2 binds collagen type I, II, III, V, X fibrils (Canis familiaris)
RHEA:70733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in) => 4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out)
REACT:R-MMU-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Mus musculus)
REACT:R-BTA-9021306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds and inactivates C1r, C1s (Bos taurus)
RHEA:40796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
RHEA:25071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + ATP + CoA => 3-hydroxybenzoyl-CoA + AMP + diphosphate
REACT:R-GGA-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Gallus gallus)
RHEA:70067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0103103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity
RHEA:50436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H1 = prostaglandin E1
RHEA:28495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + dimethyl sulfide + H2O => a menaquinol + dimethyl sulfoxide
RHEA:28661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactose + beta-D-glucose => beta-lactose + H2O
GO:0009670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triose phosphate antiporter
GO:0009670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate:phosphate antiporter activity
GO:0009670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triose-phosphate:phosphate antiporter activity
GO:0009670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPT
GO:0009670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triose phosphate translocator
REACT:R-SSC-75090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR1 homodimer to dsRNA duplex (Sus scrofa)
REACT:R-SSC-446634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 is activated by autophosphorylation (Sus scrofa)
RHEA:49543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate <=> (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate
RHEA:53207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:18557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA
RHEA:18557	skos:prefLabel	"alkylglycerophosphate 2-O-acetyltransferase"
RHEA:18557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkylglycerophosphate 2-O-acetyltransferase"
REACT:R-HSA-9613760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2 gene expression (Homo sapiens)
REACT:R-HSA-9014343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex (Homo sapiens)
RHEA:42329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
GO:0043295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione binding
RHEA:17179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-octanoyl-(R)-carnitine => (R)-carnitine + octanoyl-CoA
RHEA:71978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(out) + 3 Na(+)(out) <=> glutathione(in) + 3 Na(+)(in)
GO:0051733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA 5'-hydroxyl kinase activity
GO:0051733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA kinase activity
GO:0051733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polydeoxyribonucleotide kinase activity
RHEA:51098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-5687091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 binds MAPKAPK5 (Sus scrofa)
GO:1904593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin binding
REACT:R-DRE-5675456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer (Danio rerio)
REACT:R-HSA-9607301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2 binds SOS1 (Homo sapiens)
REACT:R-HSA-202541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)
RHEA:43668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hexacosanoyl-CoA + hydrogencarbonate = 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate
REACT:R-CFA-199219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Canis familiaris)
RHEA:35687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetradecasphinganine = 3-oxotetradecasphinganine + H(+) + NADPH
RHEA:23641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 => CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate
REACT:R-BTA-417898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y4 receptor can bind to UTP (Bos taurus)
REACT:R-DRE-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Danio rerio)
REACT:R-RNO-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Rattus norvegicus)
RHEA:70233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-benzoylsuccinyl-CoA + H(+) + NADH => (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+)
REACT:R-CFA-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Canis familiaris)
REACT:R-BTA-5228523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates MDM2 with SUMO1 (Bos taurus)
REACT:R-HSA-6810937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lamellar bodies bind the early cornified envelope (Homo sapiens)
RHEA:13977	skos:altLabel	"D-serine deaminase"
RHEA:13977	skos:altLabel	"D-hydroxy amino acid dehydratase"
RHEA:13977	skos:altLabel	"D-serine dehydratase"
RHEA:13977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine = NH4(+) + pyruvate
RHEA:13977	skos:prefLabel	"D-serine ammonia-lyase"
RHEA:13977	skos:altLabel	"D-serine hydrolase"
RHEA:13977	skos:altLabel	"D-serine dehydrase"
RHEA:13977	skos:altLabel	"D-serine dehydratase (deaminating)"
RHEA:13977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-serine ammonia-lyase"
RHEA:13977	skos:altLabel	"D-serine hydro-lyase (deaminating)"
REACT:R-CFA-9024334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Canis familiaris)
EC:1.14.14.177	skos:altLabel	"CYP4F22"
EC:1.14.14.177	skos:prefLabel	"ultra-long-chain fatty acid omega-hydroxylase"
EC:1.14.14.177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ultra-long-chain fatty acid omega-hydroxylase"
GO:0106237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonate 12(R)-lipoxygenase activity
GO:0106237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
RHEA:23502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+)
REACT:R-MMU-5626962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB2L1 binds IKKA:IKKB:NEMO (Mus musculus)
REACT:R-MMU-5626228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The distal appendage proteins recruit TTBK2 (Mus musculus)
REACT:R-GGA-8952996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 forms homodimers (Gallus gallus)
REACT:R-XTR-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Xenopus tropicalis)
REACT:R-XTR-5661122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2R3-histone H3 (Xenopus tropicalis)
REACT:R-SSC-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Sus scrofa)
RHEA:57024	skos:prefLabel	"apulose-4-phosphate transketolase"
RHEA:57024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apulose 4-phosphate + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + dihydroxyacetone phosphate
RHEA:57024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"apulose-4-phosphate transketolase"
REACT:R-CFA-4551768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO2,3 (Canis familiaris)
REACT:R-DRE-5672957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates KSR1 (Danio rerio)
REACT:R-SPO-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)
REACT:R-BTA-4655355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Bos taurus)
RHEA:41307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:52811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine in U6 snRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine
REACT:R-PFA-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Plasmodium falciparum)
RHEA:18495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-benzoylglycine => benzoyl-CoA + glycine
RHEA:17280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
RHEA:29598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NADP(+) + sulfoacetaldehyde <=> H(+) + NADPH + sulfoacetyl-CoA
RHEA:12842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine + pyruvate => L-alanine + pyridoxal
GO:0062080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inhibitory MHC class Ib receptor activity
RHEA:59661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotetraose + O2 => D-cellotetraono-1,5-lactone + H2O2
GO:0047230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity
GO:0047230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol-3-O-glucoside L-rhamnosyltransferase activity
GO:0047230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity
GO:0047230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity
REACT:R-SSC-6786789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer binds FLT3 (Sus scrofa)
REACT:R-MMU-443783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NUMB with L1 (Mus musculus)
REACT:R-SPO-927830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Schizosaccharomyces pombe)
RHEA:67706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O
REACT:R-SSC-1470010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs (Sus scrofa)
REACT:R-BTA-8848864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARAP1 (Bos taurus)
REACT:R-DRE-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Danio rerio)
EC:4.1.99.-	skos:prefLabel	"Other carbon-carbon lyases"
EC:4.1.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other carbon-carbon lyases"
RHEA:59968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-threonyl-[protein]
RHEA:67035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:42866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + norspermine + S-methyl-5'-thioadenosine => norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine
REACT:R-RNO-109860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 phosphorylates MAPK3 (Rattus norvegicus)
RHEA:66720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) = ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate
REACT:R-MMU-5691381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYSM1 deubiquitinates Histone H2A (Mus musculus)
RHEA:50637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O
REACT:R-HSA-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Homo sapiens)
RHEA:35446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose <=> an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP
RHEA:72535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + vanillin = 2 H(+) + NADPH + vanillate
RHEA:54239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycerol + CDP-choline <=> 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:23019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) <=> (2R,3R)-dihydrokaempferol + H(+) + NADPH
RHEA:40861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-hexadecadienoyl-CoA + FADH2 => (9Z)-hexadecenoyl-CoA + FAD + H(+)
REACT:R-SSC-9005995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the SIN3A co-repressor complex (Sus scrofa)
RHEA:14189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophan + O2 = N-formyl-D-kynurenine
REACT:R-SSC-1483096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA is dephosphorylated to ETA by PHOSPHO1 (Sus scrofa)
REACT:R-DME-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Drosophila melanogaster)
RHEA:68706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate)
RHEA:47609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA
RHEA:54765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)
REACT:R-CFA-8936608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)
RHEA:65144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + berkeleyone A + O2 = CO2 + H2O + preaustinoid A + succinate
RHEA:43585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + iminoarginine => 5-guanidino-2-oxopentanoate + NH4(+)
EC:3.1.4.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphoric diester hydrolases"
EC:3.1.4.-	skos:prefLabel	"Phosphoric diester hydrolases"
REACT:R-CFA-5649873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Canis familiaris)
REACT:R-XTR-1250346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Xenopus tropicalis)
RHEA:57016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:12202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + mugineate + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2
REACT:R-BTA-451900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RB binds JAK1 (Bos taurus)
RHEA:10003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pentanamide <=> NH4(+) + pentanoate
REACT:R-RNO-4793911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates HSF1 (Rattus norvegicus)
REACT:R-CFA-6788571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 bind IL13:IL13R type II (Canis familiaris)
RHEA:13610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)
RHEA:29868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ITP => ADP + IDP
REACT:R-DME-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Drosophila melanogaster)
REACT:R-SCE-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Saccharomyces cerevisiae)
REACT:R-BTA-9649963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC3 channel blockers bind ASIC3 trimer (Bos taurus)
REACT:R-DRE-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Danio rerio)
REACT:R-DRE-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)
REACT:R-DME-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Drosophila melanogaster)
REACT:R-CEL-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Caenorhabditis elegans)
RHEA:35107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitrotyramine + H2O + O2 = 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)
REACT:R-DME-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Drosophila melanogaster)
RHEA:10577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + N-methylethanolamine phosphate => CDP-N-methylethanolamine + diphosphate
REACT:R-RNO-9033527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Rattus norvegicus)
REACT:R-XTR-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Xenopus tropicalis)
RHEA:66634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP => L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-CFA-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Canis familiaris)
RHEA:13116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetamidofluorene + H2O + NADP(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADPH
RHEA:23404	skos:altLabel	"(S)-3-O-geranylgeranylglyceryl phosphate synthase"
RHEA:23404	skos:prefLabel	"phosphoglycerol geranylgeranyltransferase"
RHEA:23404	skos:altLabel	"GGGPS"
RHEA:23404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglycerol geranylgeranyltransferase"
RHEA:23404	skos:altLabel	"GGGP synthase"
RHEA:23404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
RHEA:23517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + ATP => (2R)-3-phosphoglycerate + ADP + H(+)
RHEA:38499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)
REACT:R-BTA-5694441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1D phosphorylates SEC23 (Bos taurus)
REACT:R-BTA-9021660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds membrane-associated estrogen receptors (Bos taurus)
RHEA:47187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:12102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + microthecin => 1,5-anhydro-D-fructose
REACT:R-CFA-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Canis familiaris)
REACT:R-SSC-1678981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR9 processing at neutral pH (Sus scrofa)
REACT:R-HSA-6814671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)
REACT:R-RNO-6806613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin tetramers bind to form unit length filaments (Rattus norvegicus)
RHEA:43563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate
REACT:R-SSC-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Sus scrofa)
RHEA:30261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a menaquinone + 2 H2O => 2 a menaquinol + O2
REACT:R-HSA-1676168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane (Homo sapiens)
GO:0008973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribomutase activity
GO:0008973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribose phosphomutase activity
GO:0008973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopentomutase activity
GO:0008973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribose 1,5-phosphomutase activity
GO:0008973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-ribose 1,5-phosphomutase activity
GO:0008973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity
GO:0008973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribomutase activity
GO:0008973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Homo sapiens)
GO:0008973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphodeoxyribomutase activity
RHEA:71737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + succinyl-CoA => formyl-CoA + succinate
RHEA:57731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + trans-aconitate <=> CO2 + itaconate
REACT:R-RNO-5654425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds SHC1 (Rattus norvegicus)
RHEA:28580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(2+)(out) => Co(2+)(in)
RHEA:33189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate
REACT:R-CFA-389995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Canis familiaris)
REACT:R-DRE-2294590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds phosphorylated condensin II complex (Danio rerio)
REACT:R-MMU-446692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 binds to MYD88 within the IL1R complex (Mus musculus)
RHEA:36792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-hydroxy-L-arginine => hydroxyurea + L-ornithine
RHEA:18227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-aminohexanoate + [N-(6-aminohexanoyl)](n-1) => [N-(6-aminohexanoyl)](n) + H2O
GO:0018271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-apoprotein ligase activity
GO:0018271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-protein ligase activity
RHEA:18698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + H(+) => (4-hydroxyphenyl)acetaldehyde + CO2
REACT:R-MMU-8964599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Mus musculus)
RHEA:48349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in RNA => a pseudouridine in RNA
REACT:R-RNO-2453855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)
RHEA:71914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate(out) + 2 Na(+)(out) <=> cholate(in) + 2 Na(+)(in)
REACT:R-SSC-8943041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Sus scrofa)
RHEA:15647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin]
RHEA:54028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:16899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid ester + a diacylglycerol => a 3beta-hydroxysteroid + a triacylglycerol
REACT:R-GGA-5610720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI3 (Gallus gallus)
REACT:R-SCE-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Saccharomyces cerevisiae)
REACT:R-SSC-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)
RHEA:51209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-leukotriene B4 + NADP(+) => 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH
REACT:R-SSC-8948232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Sus scrofa)
REACT:R-SSC-2029453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of VAV (Sus scrofa)
REACT:R-SCE-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Saccharomyces cerevisiae)
REACT:R-MMU-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Mus musculus)
REACT:R-HSA-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Homo sapiens)
RHEA:61342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)
RHEA:44698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H2O
REACT:R-DRE-8849857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates CELA2 (Danio rerio)
RHEA:48928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide
REACT:R-SSC-5651723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)
REACT:R-MMU-6810357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fillagrin and keratin intermediate filaments polymerise forming a network (Mus musculus)
RHEA:30188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + a quinone => a quinol + orotate
REACT:R-SSC-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Sus scrofa)
RHEA:64025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)
RHEA:58518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:67992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + trichloroethene = (Z)-1,2-dichloroethene + A + chloride + H(+)
RHEA:45523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]
RHEA:36029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + propanoyl-CoA => CoA + NAD(+) + propanal
RHEA:20411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + FMN => alpha-D-glucose 1-phosphate + riboflavin
REACT:R-GGA-373006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O + oxaloacetate => citrate + CoA (Gallus gallus)
RHEA:66625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1889955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT dimers transfer GlcA to tetrasaccharide linker (Homo sapiens)
REACT:R-CFA-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Canis familiaris)
REACT:R-CFA-6788611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYKK phosphorylates 5HLYS (Canis familiaris)
REACT:R-RNO-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Rattus norvegicus)
RHEA:56708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56708	skos:altLabel	"CYP87D16"
RHEA:56708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-amyrin 16alpha-hydroxylase"
RHEA:56708	skos:prefLabel	"beta-amyrin 16alpha-hydroxylase"
RHEA:20747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin D2 <=> 15-oxoprostaglandin D2 + H(+) + NADPH
GO:0047577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-hydroxybutyrate dehydrogenase activity
GO:0047577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde
GO:0047577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybutanoate:NAD+ oxidoreductase activity
GO:0047577	skos:prefLabel	"4-hydroxybutyrate dehydrogenase"
GO:0047577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutyrate dehydrogenase activity
GO:0047577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybutyrate dehydrogenase"
REACT:R-CFA-156661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Exon Junction Complex (Canis familiaris)
EC:2.4.1.113	skos:prefLabel	"alpha-1,4-glucan-protein synthase (ADP-forming)"
EC:2.4.1.113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-1,4-glucan-protein synthase (ADP-forming)"
REACT:R-GGA-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Gallus gallus)
REACT:R-GGA-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Gallus gallus)
RHEA:13669	skos:prefLabel	"3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase"
RHEA:13669	skos:altLabel	"3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase"
RHEA:13669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 3-hydroxy-2-methylpyridine-5-carboxylate + CO2
RHEA:13669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase"
RHEA:19171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + pyruvate => L-serine
REACT:R-CFA-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Canis familiaris)
REACT:R-CFA-1296043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of HCN channels (Canis familiaris)
REACT:R-RNO-8847638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Rattus norvegicus)
REACT:R-MMU-5649883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB-mediated DNA strand displacement synthesis (Mus musculus)
REACT:R-CFA-388832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds CD28 (Canis familiaris)
REACT:R-MMU-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Mus musculus)
REACT:R-MMU-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Mus musculus)
REACT:R-SSC-8982641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Sus scrofa)
RHEA:59644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylobiono-1,5-lactone + H2O = D-xylobionate + H(+)
RHEA:60845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-guanosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate
REACT:R-RNO-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Rattus norvegicus)
RHEA:29656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(in) => L-cysteine(out)
REACT:R-DME-9026967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 inhibitors binds VKORC1 dimer (Drosophila melanogaster)
REACT:R-SPO-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)
RHEA:53306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate => AH2 + 2 ATP + 2 cob(II)alamin
REACT:R-GGA-5696490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:CLCF1 binds CNTRF (Gallus gallus)
REACT:R-PFA-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Plasmodium falciparum)
REACT:R-MMU-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)
REACT:R-MMU-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Mus musculus)
REACT:R-RNO-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Rattus norvegicus)
RHEA:24954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-D-muramate 6-phosphate => 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O
REACT:R-GGA-4755494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Gallus gallus)
REACT:R-BTA-8943959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP9 cleave SCUBE3 (Bos taurus)
GO:0046965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear retinoid X receptor binding
GO:0046965	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinoid X receptor binding
GO:0046965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXR binding
RHEA:27533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (3S,6E)-nerolidol + diphosphate
RHEA:25820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermidine = 4-aminobutanal + H2O2 + propane-1,3-diamine
RHEA:44834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-tetradecanoyl-(R)-carnitine => (R)-carnitine + tetradecanoyl-CoA
REACT:R-GGA-417077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of telomerase RNP to a telomeric chromosome end (Gallus gallus)
REACT:R-CEL-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)
REACT:R-MMU-2029467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
REACT:R-DRE-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Danio rerio)
REACT:R-DDI-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Dictyostelium discoideum)
RHEA:69165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) => 2 H(+) + N-(2-carboxyethyl)putrescine + NADH
REACT:R-HSA-2168923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XVIII endostatin release (Homo sapiens)
REACT:R-HSA-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Homo sapiens)
REACT:R-SSC-909721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ISGF3 complex to nucleus (Sus scrofa)
REACT:R-BTA-6785898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R binds JAK2 (Bos taurus)
REACT:R-DDI-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Dictyostelium discoideum)
EC:2.4.1.24	skos:prefLabel	"1,4-alpha-glucan 6-alpha-glucosyltransferase"
EC:2.4.1.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,4-alpha-glucan 6-alpha-glucosyltransferase"
EC:2.4.1.24	skos:altLabel	"oligoglucan-branching glycosyltransferase"
EC:1.17.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a cytochrome as acceptor"
EC:1.17.2.-	skos:prefLabel	"With a cytochrome as acceptor"
RHEA:39021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O
RHEA:23140	skos:prefLabel	"NMN nucleosidase"
RHEA:23140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NMN nucleosidase"
RHEA:23140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + H(+) + nicotinamide
RHEA:23140	skos:altLabel	"NMNase"
REACT:R-BTA-9707523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to BACH1:MAFK (Bos taurus)
RHEA:38666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)
REACT:R-RNO-9698408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates active FLT3 (Rattus norvegicus)
REACT:R-CFA-420127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGRP receptor can bind calcitonin gene-related peptides (Canis familiaris)
RHEA:64048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + sphinganine = CoA + H(+) + N-(13Z-docosenoyl)-sphinganine
GO:0102168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-phenazine-1-carboxylate N-methyltransferase activity
REACT:R-HSA-9685956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3a is externalized together with membrane structures (Homo sapiens)
RHEA:47557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + taurodeoxycholate => deoxycholate + taurine
RHEA:23256	skos:prefLabel	"adenosylcobyric acid synthase (glutamine-hydrolyzing)"
RHEA:23256	skos:altLabel	"cobyric acid synthase"
RHEA:23256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylcobyric acid synthase (glutamine-hydrolyzing)"
RHEA:23256	skos:altLabel	"Ado-cobyric acid synthase [glutamine hydrolyzing]"
RHEA:23256	skos:altLabel	"5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase"
RHEA:23256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine = adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate
EC:1.14.15.-	skos:prefLabel	"With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen"
EC:1.14.15.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen"
RHEA:37763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-BTA-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Bos taurus)
REACT:R-GGA-74726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of insulin from insulin receptor (Gallus gallus)
REACT:R-BTA-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Bos taurus)
REACT:R-SSC-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Sus scrofa)
REACT:R-DDI-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Dictyostelium discoideum)
REACT:R-HSA-4088220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endorepellin binds alpha2beta1 integrin (Homo sapiens)
RHEA:33105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-muurolene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:44203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyloctadecanoate + ATP + CoA <=> 12-methyloctadecanoyl-CoA + AMP + diphosphate
REACT:R-DRE-204850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Dok-2 (Danio rerio)
REACT:R-XTR-140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS1 (Xenopus tropicalis)
RHEA:60121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine => H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine
RHEA:57678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Danio rerio)
REACT:R-XTR-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Xenopus tropicalis)
RHEA:56724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-beta-carotene + O2 = 4-hydroxy-all-trans-beta-carotene + A + H2O
REACT:R-SSC-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Sus scrofa)
RHEA:36942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA <=> (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-GGA-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Gallus gallus)
REACT:R-CFA-83656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)
REACT:R-CFA-977071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Canis familiaris)
GO:0050384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UAR phosphorylase activity
GO:0050384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urate-ribonucleotide:phosphate D-ribosyltransferase activity
GO:0050384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity
GO:0050384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urate-ribonucleotide phosphorylase activity
REACT:R-XTR-9701507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN6 dephosphorylates JAK3 (Xenopus tropicalis)
REACT:R-SSC-354165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)
RHEA:18577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine
RHEA:18577	skos:prefLabel	"3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase"
RHEA:18577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase"
REACT:R-BTA-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Bos taurus)
REACT:R-SSC-9610152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Sus scrofa)
RHEA:50324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Gallus gallus)
RHEA:47008	skos:altLabel	"siroheme sulfite reductase"
RHEA:47008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite
RHEA:47008	skos:prefLabel	"dissimilatory sulfite reductase"
RHEA:47008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dissimilatory sulfite reductase"
RHEA:47008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite
REACT:R-MMU-2730894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
RHEA:16956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(2)-succinyl-L-ornithine <=> L-glutamate + N-succinyl-L-glutamate 5-semialdehyde
REACT:R-DME-350901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is organified (Drosophila melanogaster)
REACT:R-GGA-549297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Gallus gallus)
RHEA:31018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-carboxylate <=> CO2 + indole
REACT:R-DRE-77327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Danio rerio)
RHEA:65757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]
REACT:R-XTR-139893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Granzyme-B activates BID by cleavage (Xenopus tropicalis)
REACT:R-SPO-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Schizosaccharomyces pombe)
RHEA:57281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA
REACT:R-XTR-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Xenopus tropicalis)
RHEA:32434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-menthone + H(+) + NADPH + O2 <=> (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)
REACT:R-CFA-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Canis familiaris)
REACT:R-XTR-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Xenopus tropicalis)
REACT:R-RNO-8854209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A binds JFC1 (Rattus norvegicus)
RHEA:42631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(747) in 23S rRNA <=> 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:54027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate
REACT:R-HSA-5686071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS (Homo sapiens)
RHEA:13521	skos:prefLabel	"D-lactate dehydrogenase (cytochrome)"
RHEA:13521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate
RHEA:13521	skos:altLabel	"D-lactate ferricytochrome c oxidoreductase"
RHEA:13521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-lactate dehydrogenase (cytochrome)"
RHEA:13521	skos:altLabel	"lactic acid dehydrogenase"
REACT:R-MMU-418858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoGTPase GEF's recruited to DCC (Mus musculus)
RHEA:22791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylsulfonioacetate + L-homocysteine <=> (methylsulfanyl)acetate + H(+) + L-methionine
REACT:R-MMU-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Mus musculus)
RHEA:68018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + phosphate => (2E,6E,10E)-geranylgeranyl phosphate + H2O
RHEA:67148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 = 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]
GO:0015146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentose transmembrane transporter activity
REACT:R-BTA-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Bos taurus)
RHEA:47368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidyl-myo-inositol alpha-mannosyltransferase"
RHEA:47368	skos:altLabel	"guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase"
RHEA:47368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)
RHEA:47368	skos:prefLabel	"phosphatidyl-myo-inositol alpha-mannosyltransferase"
RHEA:43071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Gallus gallus)
RHEA:18962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allose + L-lysyl-[protein] => H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]
REACT:R-CFA-176646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Canis familiaris)
RHEA:30069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + 2 H(+) + NADPH => betaine aldehyde + H2O + NADP(+)
RHEA:33882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-scyllo-inosamine + NADP(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH
REACT:R-DME-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)
EC:3.4.24.15	skos:prefLabel	"thimet oligopeptidase"
EC:3.4.24.15	skos:altLabel	"soluble metalloendopeptidase"
EC:3.4.24.15	skos:altLabel	"endopeptidase 24.15"
EC:3.4.24.15	skos:altLabel	"Pz-peptidase"
EC:3.4.24.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thimet oligopeptidase"
EC:3.4.24.15	skos:altLabel	"endo-oligopeptidase A"
REACT:R-CFA-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Canis familiaris)
REACT:R-SCE-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Saccharomyces cerevisiae)
REACT:R-CEL-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Caenorhabditis elegans)
REACT:R-DRE-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Danio rerio)
RHEA:20516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aryl-2-methylmalonate + H(+) <=> 2-arylpropionate + CO2
REACT:R-HSA-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Homo sapiens)
REACT:R-DRE-8870352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Danio rerio)
REACT:R-RNO-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Rattus norvegicus)
REACT:R-RNO-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Rattus norvegicus)
GO:0008757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl methionine-dependent methyltransferase activity
GO:0008757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylmethionine-dependent methyltransferase activity
GO:0008757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAM-dependent methyltransferase activity
GO:0018579	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocatechuic 4,5-oxygenase activity
GO:0018579	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)
GO:0018579	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocatechuic 4,5-dioxygenase activity
GO:0018579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protocatechuate 4,5-dioxygenase activity
GO:0018579	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocatechuate 4,5-oxygenase activity
RHEA:12444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hexadecenal reductase"
RHEA:12444	skos:prefLabel	"2-hexadecenal reductase"
RHEA:12444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanal + NADP(+) = (2E)-hexadecenal + H(+) + NADPH
RHEA:12444	skos:altLabel	"2-alkenal reductase"
REACT:R-HSA-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Homo sapiens)
RHEA:41907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)
REACT:R-DRE-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Danio rerio)
REACT:R-HSA-5684108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 binds phosphorylated RBBP8 (Homo sapiens)
REACT:R-CFA-1250348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by ERBB4 homodimers (Canis familiaris)
RHEA:27868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + alpha-D-mannose 6-phosphate => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O
REACT:R-SSC-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Sus scrofa)
REACT:R-RNO-8951486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C4b (Rattus norvegicus)
RHEA:25408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + D-glucose = ADP + alpha,alpha-trehalose + H(+)
GO:0047540	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butanoate:NAD+ delta2-oxidoreductase activity
GO:0047540	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoate reductase activity
GO:0047540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-enoate reductase activity
RHEA:15654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 2,6-bisphosphate + H(+)
REACT:R-MMU-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Mus musculus)
REACT:R-CFA-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Canis familiaris)
REACT:R-GGA-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Gallus gallus)
REACT:R-MMU-9645520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)
GO:0030620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U2 snRNA binding
REACT:R-CFA-372697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binding to p130cas (Canis familiaris)
GO:0000016	skos:prefLabel	"lactase"
GO:0000016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactase"
GO:0000016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lactose = beta-D-galactose + D-glucose
GO:0000016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose galactohydrolase activity
GO:0000016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactase activity
REACT:R-CFA-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Canis familiaris)
REACT:R-HSA-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Homo sapiens)
REACT:R-GGA-109530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Gallus gallus)
RHEA:61069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + horhammericine => 19-O-acetylhorhammericine + CoA
RHEA:41147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-CEL-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Caenorhabditis elegans)
REACT:R-GGA-9603302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (peptide) binds IIa (Gallus gallus)
REACT:R-CFA-209944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D binds GC (Canis familiaris)
REACT:R-DRE-8933452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE dimer binds phosphorylated DENND1 proteins (Danio rerio)
REACT:R-HSA-3000449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Homo sapiens)
RHEA:54629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dodecanoyl-CoA + O2 => 2-hydroxydodecanoyl-CoA + CO2 + succinate
REACT:R-SSC-997326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Sus scrofa)
REACT:R-DDI-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Dictyostelium discoideum)
RHEA:58174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-pinacene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-CEL-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Caenorhabditis elegans)
REACT:R-DRE-5685649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPAs translocate from ER membrane to extracellular region (Danio rerio)
RHEA:50639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O
RHEA:24999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Sus scrofa)
RHEA:56797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(I)alamin-[corrinoid adenosyltransferase] => adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate
REACT:R-MMU-211164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO1A (Mus musculus)
RHEA:52346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate
RHEA:48002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NADP(+) => 1,6-dihydro-beta-NADP + H(+) + O2
RHEA:57635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Rattus norvegicus)
GO:0033694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor
GO:0033694	skos:prefLabel	"With an iron-sulfur protein as acceptor"
GO:0033694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With an iron-sulfur protein as acceptor"
REACT:R-RNO-9029517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Rattus norvegicus)
RHEA:13276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol <=> 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)
REACT:R-RNO-5649799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Rattus norvegicus)
REACT:R-XTR-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Xenopus tropicalis)
RHEA:65183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + protoaustinoid B <=> A + H2O + preaustinoid A
REACT:R-MMU-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Mus musculus)
REACT:R-DME-209376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPN27A binds to and inhibits EA protease activity (Drosophila melanogaster)
REACT:R-HSA-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Homo sapiens)
RHEA:18092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginyl-[protein] <=> L-citrullyl-[protein] + NH4(+)
REACT:R-RNO-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Rattus norvegicus)
GO:2001071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltoheptaose binding
REACT:R-DME-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Drosophila melanogaster)
GO:0018572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dichlorocatechol 1,2-dioxygenase activity
REACT:R-CFA-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)
REACT:R-RNO-140355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS1 (Rattus norvegicus)
REACT:R-DDI-6804276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TTC5 (Dictyostelium discoideum)
REACT:R-BTA-429613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Bos taurus)
RHEA:60645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + androsterone => adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)
RHEA:15369	skos:prefLabel	"2,3-dihydroxybenzoate 2,3-dioxygenase"
RHEA:15369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-dihydroxybenzoate 2,3-dioxygenase"
RHEA:15369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H(+)
RHEA:45228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA
REACT:R-MMU-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Mus musculus)
REACT:R-HSA-2161907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Homo sapiens)
RHEA:17827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glucose 6-phosphate + H(+) => ATP + D-glucose
REACT:R-DME-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)
RHEA:10862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acetamidomethylene)succinate + NAD(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2
REACT:R-HSA-9660824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
REACT:R-RNO-5609665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)
RHEA:70059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:11610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA
RHEA:66487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxygypsogenate + UDP-alpha-D-glucose <=> 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP
RHEA:16119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + AMP + diphosphate => acetoacetate + ATP + CoA
RHEA:15185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-arginine
REACT:R-PFA-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)
REACT:R-DRE-9018868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Danio rerio)
GO:0061542	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	5-demethylubiquinone-9 methyltransferase
GO:0061542	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase
GO:0061542	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OMHMB-methyltransferase
GO:0061542	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase
GO:0061542	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	5-demethylubiquinone-10 methyltransferase
GO:0061542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-n 3-O-methyltransferase activity
REACT:R-BTA-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Bos taurus)
REACT:R-SSC-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Sus scrofa)
RHEA:53911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]
REACT:R-XTR-927830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Xenopus tropicalis)
REACT:R-BTA-9706364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of ubiquitinated FLT3 (Bos taurus)
RHEA:32496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)
REACT:R-BTA-176702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Processive Complex and Completed Telomere End (Bos taurus)
RHEA:31674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:22927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H(+) + H2O <=> dUMP + NH4(+)
REACT:R-BTA-211186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DFF45 (224) by caspase-3 (Bos taurus)
RHEA:37812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:22988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + CoA + NADP(+) = acetyl-CoA + CO2 + NADPH
RHEA:24330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyldihydrofolate + ADP + phosphate => 7,8-dihydrofolate + ATP + formate
REACT:R-HSA-76496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)
REACT:R-XTR-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Xenopus tropicalis)
RHEA:52532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + GTP = AMP + GDP + H(+)
REACT:R-CFA-9034042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Canis familiaris)
REACT:R-BTA-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Bos taurus)
REACT:R-SSC-9668395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CC2D1B (Sus scrofa)
REACT:R-BTA-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Bos taurus)
REACT:R-DDI-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)
REACT:R-GGA-420724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds Ca2+ (Gallus gallus)
REACT:R-XTR-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Xenopus tropicalis)
REACT:R-BTA-6799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates TP53 (Bos taurus)
REACT:R-DRE-8956659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates YAP1 (Danio rerio)
REACT:R-RNO-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Rattus norvegicus)
RHEA:58080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-docosanoylglycerol + H2O = docosanoate + glycerol + H(+)
RHEA:43512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(dihydroxymethyl)-5-formylfuran + O2 = 2-carboxy-5-formylfuran + H(+) + H2O2
REACT:R-RNO-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Rattus norvegicus)
REACT:R-DRE-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)
REACT:R-DME-265682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Drosophila melanogaster)
REACT:R-HSA-2671742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin (Homo sapiens)
RHEA:47947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> (2E)-geranyl phosphate + H(+) + phosphate
GO:0051109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonobetaine-CoA synthase activity
GO:0051109	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	crotonobetaine/carnitine-CoA ligase activity
GO:0051109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonobetaine-CoA ligase activity
REACT:R-GGA-8876454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND3 exchanges GTP for GDP on RAB12 (Gallus gallus)
EC:3.2.1.109	skos:prefLabel	"endogalactosaminidase"
EC:3.2.1.109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endogalactosaminidase"
GO:0061953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA (adenine-N1-)-methyltransferase activity
REACT:R-XTR-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Xenopus tropicalis)
RHEA:64983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Saccharomyces cerevisiae)
REACT:R-CFA-193705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
RHEA:51301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-phenylalanine => H2O + N-(9Z-octadecenoyl)-L-phenylalanine
REACT:R-BTA-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Bos taurus)
GO:0047462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine racemase (adenosine triphosphate-hydrolysing)
GO:0047462	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phenylalanine racemase (ATP-hydrolysing)
GO:0047462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine racemase (ATP-hydrolyzing) activity
GO:0047462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gramicidin S synthetase I
GO:0047462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine racemase activity
REACT:R-RNO-9704248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM4 binds CHRM4 antagonists (Rattus norvegicus)
REACT:R-HSA-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Homo sapiens)
RHEA:19970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylamine + O2 => H(+) + H2O + nitrite
REACT:R-SSC-9678737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR1:TYK2 binds TYK2 inhibitors (Sus scrofa)
RHEA:31696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
REACT:R-CEL-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Caenorhabditis elegans)
RHEA:17152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] <=> an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trihydroxybenzophenone synthase activity
REACT:R-HSA-9013974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF3 within activated TLR3 complex (Homo sapiens)
REACT:R-RNO-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Rattus norvegicus)
RHEA:37480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-SSC-1482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by HADH (IM) (Sus scrofa)
REACT:R-HSA-430201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76:ADAP binds Ena/VASP (Homo sapiens)
REACT:R-HSA-109338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Homo sapiens)
GO:0102388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N,N'-diacetylbacillosamine 2-epimerase activity
RHEA:65242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoate + CoA + H(+) => (11Z)-octadecenoyl-CoA + H2O
REACT:R-HSA-5696119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Homo sapiens)
RHEA:25917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-6-ol => 6-hydroxyquinolin-2(1H)-one + AH2
REACT:R-DME-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Drosophila melanogaster)
RHEA:11021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)
GO:0008031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eclosion hormone activity
RHEA:67116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:34365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP
REACT:R-RNO-420243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHRH receptor binds GHRH (Rattus norvegicus)
REACT:R-DRE-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Danio rerio)
REACT:R-CFA-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Canis familiaris)
REACT:R-SPO-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Schizosaccharomyces pombe)
REACT:R-HSA-432712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Homo sapiens)
REACT:R-SSC-351913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of TJP1 (Sus scrofa)
REACT:R-RNO-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Rattus norvegicus)
REACT:R-XTR-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Xenopus tropicalis)
RHEA:72284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
GO:0070851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth factor receptor binding
REACT:R-SPO-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Schizosaccharomyces pombe)
RHEA:33350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminoacetate + H2O <=> glyoxylate + NH4(+)
REACT:R-RNO-77329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Rattus norvegicus)
REACT:R-DDI-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Dictyostelium discoideum)
RHEA:40610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycerol + H2O <=> glycerol + H(+) + tetradecanoate
RHEA:61337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + protoporphyrin IX(in) => ADP + H(+) + phosphate + protoporphyrin IX(out)
REACT:R-HSA-5682111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)
REACT:R-HSA-9031803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Maresin-like SPMs translocate from cytosol to extracellular region (Homo sapiens)
REACT:R-GGA-983427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of peptide bound class I MHC on cell surface (Gallus gallus)
REACT:R-SSC-2002428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen N-propeptides (Sus scrofa)
RHEA:38109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-L-galactonate
GO:0008787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-allose-6-kinase activity
GO:0008787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	allokinase activity
GO:0008787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-allose 6-phosphotransferase activity
GO:0008787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allose kinase activity
GO:0008787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-allokinase activity
GO:0008787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	allokinase (phosphorylating)
RHEA:72846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA(in) + ADP(out) <=> 3'-dephospho-CoA(out) + ADP(in)
REACT:R-MMU-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Mus musculus)
GO:0015614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose-importing ATPase activity
GO:0015614	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-xylose porter activity
GO:0015614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type D-xylose transporter activity
GO:0015614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled D-xylose transmembrane transporter activity
REACT:R-BTA-5610735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB binds ITCH (Bos taurus)
REACT:R-MMU-5666160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)
REACT:R-MMU-432129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds and phosphorylates LRP8 (Mus musculus)
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galacturan 1,4-alpha-galacturonidase activity
GO:0047911	skos:prefLabel	"galacturonan 1,4-alpha-galacturonidase"
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-D-galacturonanase activity
GO:0047911	skos:altLabel	"exopolygalacturonase"
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate
GO:0047911	skos:altLabel	"poly(galacturonate) hydrolase"
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-polygalacturonase activity
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-D-galacturonase activity
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exopolygalacturonase activity
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(galacturonate) hydrolase activity
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galacturonan 1,4-alpha-galacturonidase"
GO:0047911	skos:altLabel	"galacturan 1,4-alpha-galacturonidase"
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exopoly-D-galacturonase activity
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galacturan alpha-1,4-galacturonidase activity
GO:0047911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity
REACT:R-PFA-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Plasmodium falciparum)
REACT:R-HSA-1250189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Homo sapiens)
EC:3.4.18.-	skos:prefLabel	"Cysteine-type carboxypeptidases"
EC:3.4.18.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Cysteine-type carboxypeptidases"
RHEA:62478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein]
REACT:R-HSA-430021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)
RHEA:14260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)
REACT:R-DRE-9667456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B bind desmopressin (Danio rerio)
RHEA:28561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + H2O <=> D-fructose + phosphate
REACT:R-CFA-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Canis familiaris)
RHEA:28145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + streptothricin D <=> streptothricin D acid
GO:0120328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent DNA (cytosine-5-)-methyltransferase activity
GO:0120328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine
REACT:R-HSA-6806412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 and AP-1 bind the MSH2 promoter (Homo sapiens)
REACT:R-HSA-9616368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-CDK5R1,2 bind CDK5 (Homo sapiens)
REACT:R-DRE-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Danio rerio)
RHEA:67123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-HSA-6794354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)
RHEA:38228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9Z)-octadecenoate
REACT:R-SSC-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)
REACT:R-HSA-9683735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA9 is translated to Nucleoprotein (Homo sapiens)
REACT:R-RNO-5686704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates DCLRE1C (Rattus norvegicus)
REACT:R-MMU-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Mus musculus)
RHEA:62668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyherqueinone + H(+) + NADPH + O2 = H2O + herqueinone + NADP(+)
REACT:R-SSC-4420140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Sus scrofa)
REACT:R-CFA-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Canis familiaris)
RHEA:44731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)
REACT:R-RNO-4720446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Rattus norvegicus)
RHEA:19981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione
REACT:R-DRE-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Danio rerio)
REACT:R-CFA-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Canis familiaris)
REACT:R-SSC-202721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 binds JAM3 (Sus scrofa)
REACT:R-CFA-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Canis familiaris)
REACT:R-HSA-5358336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB forms mixed disulphides with Hh precursors (Homo sapiens)
REACT:R-GGA-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Gallus gallus)
RHEA:31749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+)
RHEA:39820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-BTA-446391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the PINCH-ILK-parvin complex (Bos taurus)
REACT:R-SSC-2984258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 phosphorylates NEK6/NEK7 (Sus scrofa)
REACT:R-MMU-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Mus musculus)
RHEA:30828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
RHEA:65150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + trilobatin + UDP => phloretin + UDP-alpha-D-glucose
RHEA:60669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-chrysanthemol + NAD(+) => (1R,3R)-chrysanthemal + H(+) + NADH
REACT:R-GGA-8956684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH polyubiquitinates TP73 (Gallus gallus)
REACT:R-MMU-432295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI binds Fyn and Lyn (Mus musculus)
RHEA:56627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)
GO:0004414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoserine O-trans-acetylase activity
GO:0004414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homoserine O-acetyltransferase activity
GO:0004414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-homoserine O-acetyltransferase activity
GO:0004414	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	homoserine transacetylase activity
GO:0004414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoserine acetyltransferase activity
GO:0004414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoserine-O-transacetylase activity
GO:0004414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:L-homoserine O-acetyltransferase activity
REACT:R-MMU-9614273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGRG heterodimer translocates to plasma membrane (Mus musculus)
REACT:R-BTA-8953013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 binds E2F8 (Bos taurus)
RHEA:60019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene B
RHEA:23704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GTP cyclohydrolase II"
RHEA:23704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate
RHEA:23704	skos:prefLabel	"GTP cyclohydrolase II"
RHEA:35263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
RHEA:46772	skos:prefLabel	"sn-1 stearoyl-lipid 9-desaturase"
RHEA:46772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sn-1 stearoyl-lipid 9-desaturase"
RHEA:46772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:54406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-RNO-6800298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF dimer binds MET (Rattus norvegicus)
REACT:R-GGA-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Gallus gallus)
RHEA:65975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a peptide antigen(in) + ATP + H2O <=> a peptide antigen(out) + ADP + H(+) + phosphate
RHEA:28494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"respiratory dimethylsulfoxide reductase"
RHEA:28494	skos:altLabel	"DMSO reductase"
RHEA:28494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + dimethyl sulfide + H2O = a menaquinol + dimethyl sulfoxide
RHEA:28494	skos:altLabel	"dimethylsulfoxide reductase"
RHEA:28494	skos:prefLabel	"respiratory dimethylsulfoxide reductase"
REACT:R-HSA-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Homo sapiens)
REACT:R-SSC-3697882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN (Sus scrofa)
REACT:R-BTA-6797627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPG hydrolyses L-Asn to L-Asp (Bos taurus)
RHEA:13750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + AMP => a ribonucleoside 5'-diphosphate + ADP
REACT:R-DRE-1855159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Danio rerio)
REACT:R-RNO-5225649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP7 binds histone H3 (Rattus norvegicus)
REACT:R-HSA-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
REACT:R-HSA-9657836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the ANGPTL3 gene (Homo sapiens)
REACT:R-CFA-159733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor X to factor X (Canis familiaris)
RHEA:65035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a quinone + protoporphyrinogen IX <=> 3 a quinol + protoporphyrin IX
REACT:R-CFA-5661114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Canis familiaris)
RHEA:17914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + nitrite => H(+) + NADH + nitrate
REACT:R-CFA-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Canis familiaris)
RHEA:32027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-alpha-cuprenene synthase"
RHEA:32027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphate
RHEA:32027	skos:prefLabel	"(-)-alpha-cuprenene synthase"
RHEA:53266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone
REACT:R-DRE-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)
REACT:R-XTR-6797810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAPL1 (Xenopus tropicalis)
RHEA:19960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-dehydroinosine + O2 <=> 2 9-riburonosylhypoxanthine + 2 H(+)
REACT:R-BTA-8876868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE1 cleaves EDN1(53-90) (Bos taurus)
REACT:R-RNO-4641256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated AXIN is degraded by the proteasome (Rattus norvegicus)
RHEA:64219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-L-lyxonate + H(+) <=> CO2 + L-lyxonate
REACT:R-HSA-8950537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Homo sapiens)
RHEA:59272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine = D-cysteine
REACT:R-XTR-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Xenopus tropicalis)
RHEA:44346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dapdiamide A + H(+) + phosphate => ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate
RHEA:45928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:43199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(4) in tRNA(His) + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-174741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Bos taurus)
RHEA:24072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O
RHEA:18823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine + CoA => acetyl-CoA + choline
REACT:R-CFA-2161651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGE2 is converted to PGF2a by CBR1 (Canis familiaris)
REACT:R-RNO-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Rattus norvegicus)
REACT:R-SSC-5665751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP:FMNL2 binds Profilin:G-actin (Sus scrofa)
RHEA:14727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein]
REACT:R-XTR-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Xenopus tropicalis)
RHEA:46736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate
RHEA:26504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + ternatin C5 + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose
RHEA:24679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + formaldehyde => 5,10-methylenetetrahydromethanopterin + H2O
REACT:R-XTR-6799466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 dimerizes (Xenopus tropicalis)
REACT:R-GGA-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Gallus gallus)
REACT:R-SPO-2545203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cleaved cohesin (Schizosaccharomyces pombe)
GO:0015151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-glucoside transmembrane transporter activity
REACT:R-RNO-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Rattus norvegicus)
REACT:R-DME-377643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
REACT:R-HSA-3159259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAA:MUT binds AdoCbl (Homo sapiens)
REACT:R-DME-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Drosophila melanogaster)
RHEA:15660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) <=> 3-methylcatechol + CO2 + NADH
REACT:R-DRE-9014641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Danio rerio)
REACT:R-DDI-5668714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX1 complex (Dictyostelium discoideum)
RHEA:33523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O = acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)
REACT:R-HSA-5686335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF2RA:CSF2RB binds SFTPs (Homo sapiens)
REACT:R-GGA-264865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin A (Gallus gallus)
REACT:R-MMU-9611851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 bind ADR,NAd (Mus musculus)
GO:0106405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoprenoid diphosphate phosphatase activity
REACT:R-MMU-9670014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor VIIIa dissociates  (Mus musculus)
RHEA:20204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-phenylalanine <=> AMP + D-phenylalanine + diphosphate + H(+)
GO:0102666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-beta-4-D-glucose hydrolase activity
REACT:R-MMU-174425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Mus musculus)
REACT:R-MMU-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Mus musculus)
REACT:R-GGA-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Gallus gallus)
REACT:R-CFA-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Canis familiaris)
REACT:R-GGA-8950757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Gallus gallus)
REACT:R-BTA-5423637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR dimers reduce AFBDHO to AFBDOH (Bos taurus)
REACT:R-DRE-191830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP nuclear import and release (Danio rerio)
RHEA:27429	skos:altLabel	"lipin"
RHEA:27429	skos:altLabel	"phosphatic acid phosphatase"
RHEA:27429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidate phosphatase"
RHEA:27429	skos:altLabel	"phosphatic acid phosphohydrolase"
RHEA:27429	skos:prefLabel	"phosphatidate phosphatase"
RHEA:27429	skos:altLabel	"phosphatidic acid phosphatase"
RHEA:27429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate
RHEA:27429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate
REACT:R-MMU-5696491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNTF binds CNTFR complex (Mus musculus)
GO:0008237	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloprotease activity
GO:0008237	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloproteinase activity
GO:0008237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metallopeptidase activity
REACT:R-GGA-6804741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 forms homo- or heterodimers (Gallus gallus)
GO:0001512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NQO2
GO:0001512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-ribosyldihydronicotinamide dehydrogenase (quinone) activity
GO:0001512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosyldihydronicotinamide dehydrogenase (quinone) activity
GO:0001512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydronicotinamide riboside quinone reductase activity
GO:0001512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinone reductase 2 activity
GO:0001512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NQO2 activity
GO:0001512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	QR2 activity
GO:0001512	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NRH:quinone oxidoreductase 2 activity
REACT:R-SCE-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Saccharomyces cerevisiae)
REACT:R-HSA-376134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NrCAM binds synapse-associated proteins (Homo sapiens)
REACT:R-HSA-9706393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds ATP (Homo sapiens)
RHEA:47709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-glucose 1-phosphate + H(+) => ADP-alpha-D-glucose + phosphate
RHEA:19878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
REACT:R-MMU-352379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Mus musculus)
REACT:R-BTA-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Bos taurus)
RHEA:23702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + H(+) => 5,10-methenyltetrahydrofolate + H2O
RHEA:34519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase"
RHEA:34519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine = [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP
RHEA:34519	skos:prefLabel	"GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase"
REACT:R-DRE-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Danio rerio)
RHEA:10656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine
RHEA:10656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanidinoacetate N-methyltransferase"
RHEA:10656	skos:prefLabel	"guanidinoacetate N-methyltransferase"
REACT:R-PFA-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Plasmodium falciparum)
RHEA:54169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:14616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurine(out) <=> ADP + H(+) + phosphate + taurine(in)
RHEA:60986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-oxohexadecanoate + H(+) + NADH => 16-hydroxyhexadecanoate + NAD(+)
REACT:R-DME-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Drosophila melanogaster)
RHEA:67702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+) => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O
REACT:R-HSA-2220988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)
RHEA:70793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-ornithine(in) => H(+)(in) + L-ornithine(out)
RHEA:21863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate
RHEA:37912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA
EC:3.4.11.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Aminopeptidases"
EC:3.4.11.-	skos:prefLabel	"Aminopeptidases"
RHEA:28488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(out) => Fe(2+)(in)
REACT:R-CFA-8950504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27 binds CRLF1 (Canis familiaris)
REACT:R-MMU-389350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 by pVav1 (Mus musculus)
RHEA:23665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a (2R)-2-hydroxycarboxylate => a 2-oxocarboxylate + AH2
REACT:R-GGA-183002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Gallus gallus)
REACT:R-GGA-68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Gallus gallus)
REACT:R-CFA-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Canis familiaris)
REACT:R-DRE-5653770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Danio rerio)
RHEA:19273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate = N-acetylneuraminate + phosphate
RHEA:19273	skos:altLabel	"(NANA)condensing enzyme"
RHEA:19273	skos:altLabel	"N-acetylneuraminic acid synthase"
RHEA:19273	skos:prefLabel	"N-acetylneuraminate synthase"
RHEA:19273	skos:altLabel	"NeuAc synthase"
RHEA:19273	skos:altLabel	"N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating)"
RHEA:19273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylneuraminate synthase"
REACT:R-HSA-5637806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)
REACT:R-CEL-109530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Caenorhabditis elegans)
REACT:R-BTA-5654701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
RHEA:62115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-D-aspartate <=> H2O + iminosuccinate
RHEA:24847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O <=> 2 isomaltose
RHEA:67190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate => ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out)
RHEA:37539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-SSC-420243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHRH receptor binds GHRH (Sus scrofa)
REACT:R-BTA-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Bos taurus)
RHEA:16034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A44 + O2 => CO2 + gibberellin A19 + H2O + succinate
REACT:R-HSA-9014296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GEFs activate RAC2 (Homo sapiens)
GO:0102136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-epi-6-deoxocathasterone C-23 hydroxylase activity
GO:0102136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-351913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of TJP1 (Gallus gallus)
REACT:R-BTA-9603991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Bos taurus)
REACT:R-MMU-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Mus musculus)
RHEA:48497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose => 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP
RHEA:72734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose(in) + UMP(out) <=> UDP-alpha-D-glucose(out) + UMP(in)
RHEA:63933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisate(in) + ATP + H2O => abscisate(out) + ADP + H(+) + phosphate
RHEA:69972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Bos taurus)
RHEA:43176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"25S rRNA (cytosine(2870)-C(5))-methyltransferase"
RHEA:43176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:43176	skos:prefLabel	"25S rRNA (cytosine(2870)-C(5))-methyltransferase"
REACT:R-CFA-380303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Phospho-Nlp from the centrosome (Canis familiaris)
REACT:R-XTR-4641205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPO:LGR binds ZNRF3 (Xenopus tropicalis)
REACT:R-DRE-8851979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL9 binds immune cell surfaces (Danio rerio)
GO:0022876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity
GO:0022876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosamine PTS transporter activity
RHEA:64697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl alcohol + NAD(+) => benzaldehyde + H(+) + NADH
RHEA:72752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ochratoxin A => L-phenylalanine + ochratoxin alpha
REACT:R-SSC-5357828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8 (Sus scrofa)
REACT:R-HSA-4551616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RPA1 (RPA70) with SUMO2,3 (Homo sapiens)
RHEA:11953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate => 2-hydroxy-3-oxopropanoate
REACT:R-BTA-5690740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds B-cell receptor (Bos taurus)
REACT:R-HSA-532667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of the second glucose by glucosidase II (Homo sapiens)
REACT:R-BTA-417896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y6 receptor can bind to UDP (Bos taurus)
REACT:R-MMU-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Mus musculus)
REACT:R-SCE-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)
REACT:R-BTA-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Bos taurus)
GO:0008789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-altronate hydro-lyase activity
GO:0008789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)
GO:0008789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	altronate dehydratase activity
REACT:R-SSC-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)
RHEA:49498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+)
REACT:R-XTR-8849891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-3 bind to PSD-95 family members (Xenopus tropicalis)
RHEA:29163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) = 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)
RHEA:34073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP => trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-SSC-5635741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Sus scrofa)
RHEA:54452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH
REACT:R-XTR-4570553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO2,3 (Xenopus tropicalis)
RHEA:47193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] => Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M
RHEA:33466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	episterol + H(+) + NADPH + O2 <=> 5-dehydroepisterol + 2 H2O + NADP(+)
REACT:R-HSA-5655320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
REACT:R-XTR-193636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with the NOGO receptor (Xenopus tropicalis)
REACT:R-MMU-2029455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIA with IgG-coated Ag (Mus musculus)
RHEA:72639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine
GO:0016278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 methylates TP53 (Homo sapiens)
GO:0016278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine N-methyltransferase activity
REACT:R-RNO-9635739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 dephosphorylates p-T,Y-MAPKs (Rattus norvegicus)
RHEA:54807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 4-sulfanylbutanoate + NAD(+) <=> 4,4'-disulfanyldibutanoate + H(+) + NADH
RHEA:40553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phylloquinol + S-adenosyl-L-homocysteine => demethylphylloquinol + S-adenosyl-L-methionine
RHEA:54109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + guaia-4,6-diene
REACT:R-BTA-975040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAB-ZNF / KAP Interaction (Bos taurus)
REACT:R-CEL-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Caenorhabditis elegans)
RHEA:37497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:33247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + putrescine = 1-pyrroline + H2O2 + NH4(+)
REACT:R-MMU-9013022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GAPs stimulate RHOB GTPase activity (Mus musculus)
REACT:R-DME-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Drosophila melanogaster)
REACT:R-HSA-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Homo sapiens)
RHEA:46676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) = (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transglutaminase activity
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tissue transglutaminase
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrinoligase activity
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fibrin stabilizing factor
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGase activity
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	factor XIIIa
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glutamine gamma-glutamyltransferase activity
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-glutamine:amine gamma-glutamyltransferase
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminylpeptide gamma-glutamyltransferase activity
GO:0003810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyamine transglutaminase activity
REACT:R-CFA-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Canis familiaris)
REACT:R-HSA-77609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of APOBEC-1 to form editosome (Homo sapiens)
RHEA:69585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + inosine => guanosine + IMP
GO:0071161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanophycin synthetase activity (L-arginine-adding)
REACT:R-DME-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Drosophila melanogaster)
REACT:R-SPO-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Schizosaccharomyces pombe)
REACT:R-RNO-177275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates DARPP-32 on Thr34 (Rattus norvegicus)
GO:0042887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	amine/amide/polyamine channel activity
GO:0042887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amide transmembrane transporter activity
RHEA:55730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]
REACT:R-HSA-9662747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iRHOM2 transports ADAM17 from ER to the Golgi-network (Homo sapiens)
REACT:R-SSC-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Sus scrofa)
REACT:R-MMU-140842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n fibrin monomers -> fibrin multimer (Mus musculus)
RHEA:58859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-oxogeraniol + H(+) + NADH
REACT:R-MMU-9603982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeA to form LeB (Mus musculus)
GO:0047401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trithionate hydrolase activity
GO:0047401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trithionate thiosulfohydrolase activity
GO:0047401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trithionate hydrolase"
GO:0047401	skos:prefLabel	"trithionate hydrolase"
GO:0047401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trithionate = H(+) + sulfate + thiosulfate
REACT:R-CFA-1433514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
RHEA:32067	skos:prefLabel	"8-oxoguanine deaminase"
RHEA:32067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-oxoguanine deaminase"
RHEA:32067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxoguanine + H(+) + H2O = NH4(+) + urate
REACT:R-GGA-2029270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLCgamma to membrane (Gallus gallus)
REACT:R-CFA-1602377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Canis familiaris)
RHEA:68539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate
RHEA:10375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + phenylglyoxylate <=> benzoyl-CoA + CO2 + NADH
EC:3.1.3.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-6-phosphatase"
EC:3.1.3.9	skos:prefLabel	"glucose-6-phosphatase"
RHEA:42987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate <=> diphosphate + pimara-8(14),15-diene
GO:0052820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,N(6)-ethenoadenine N-glycosylase activity
GO:0052820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,N6-ethenoadenine glycosylase activity
GO:0052820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-1,N6-ethenoadenine N-glycosylase activity
REACT:R-RNO-6789092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide anion from oxygen (Rattus norvegicus)
REACT:R-MMU-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Mus musculus)
REACT:R-BTA-1638104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Bos taurus)
REACT:R-HSA-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Homo sapiens)
REACT:R-MMU-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Mus musculus)
RHEA:22519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + taurocyamine <=> ADP + H(+) + N-phosphotaurocyamine
REACT:R-BTA-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Bos taurus)
REACT:R-CEL-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Caenorhabditis elegans)
REACT:R-GGA-9674529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds to TBXA2R (Gallus gallus)
RHEA:14980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> 3-carboxy-cis,cis-muconate
REACT:R-SPO-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
REACT:R-DRE-4420121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate PLCG1 (Danio rerio)
REACT:R-MMU-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Mus musculus)
REACT:R-BTA-174132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Cyclin B:Cdc2 (Bos taurus)
REACT:R-SSC-976768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3b (Sus scrofa)
RHEA:12252	skos:prefLabel	"coniferin beta-glucosidase"
RHEA:12252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coniferin beta-glucosidase"
RHEA:12252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-D-glucosyl)-trans-coniferol + H2O = (E)-coniferol + D-glucose
RHEA:58752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)
REACT:R-HSA-6799695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX5,6 reduce H2O2 to H2O (Homo sapiens)
REACT:R-HSA-9698988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
REACT:R-BTA-8849353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Bos taurus)
REACT:R-CFA-173597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)
RHEA:71699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-phenylalanyl-L-leucine(out) = H(+)(in) + L-phenylalanyl-L-leucine(in)
REACT:R-SSC-419426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cannabinoid receptors can bind cannabinoids (Sus scrofa)
REACT:R-HSA-1655847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Lanosterol Demethylase (CYP51A1) (Homo sapiens)
REACT:R-CFA-5358579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase delta polymerizes DNA across single stranded gap (Canis familiaris)
REACT:R-GGA-2424480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
REACT:R-HSA-170055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Homo sapiens)
REACT:R-DRE-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Danio rerio)
GO:0047007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pregnan-21-ol dehydrogenase (NAD+) activity
GO:0047007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al
GO:0047007	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	21-hydroxysteroid dehydrogenase (NAD+) activity
GO:0047007	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	21-hydroxysteroid:NAD+ 21-oxidoreductase activity
GO:0047007	skos:prefLabel	"21-hydroxysteroid dehydrogenase (NAD(+))"
GO:0047007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"21-hydroxysteroid dehydrogenase (NAD(+))"
REACT:R-XTR-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Xenopus tropicalis)
RHEA:21877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) => (S)-usnate + 2 H(+) + NADH
RHEA:65793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:28423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
REACT:R-MMU-2730959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN7:OSTM1 exchanges Cl- for H+ (Mus musculus)
REACT:R-DME-209278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex (Drosophila melanogaster)
REACT:R-SSC-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Sus scrofa)
RHEA:21126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine
GO:0016857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	racemase and epimerase activity, acting on carbohydrates and derivatives
REACT:R-HSA-5218832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds PAK2 (Homo sapiens)
REACT:R-HSA-5654664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)
RHEA:69552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + L-glutamate = (S)-serinol phosphate + 2-oxoglutarate
REACT:R-MMU-5635868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-GLI is degraded by the proteasome (Mus musculus)
REACT:R-RNO-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Rattus norvegicus)
REACT:R-MMU-182969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:CBL) (Mus musculus)
RHEA:68092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA = a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)
REACT:R-GGA-4085994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates SIN3A with SUMO1 (Gallus gallus)
GO:0034512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	box C/D RNA binding
GO:0034512	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	box C/D sRNA binding
GO:0034512	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	box C/D snoRNA binding
RHEA:42825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 => H2O + 2 NAD(+) + tetracenomycin C
RHEA:27653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + uridine <=> GDP + H(+) + UMP
GO:0018627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzenesulfonate 2,3-dioxygenase activity
GO:0018627	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminosulfobenzene 2,3-dioxygenase activity
GO:0018627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzenesulphonate 2,3-dioxygenase activity
GO:0018627	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)
GO:0018627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzenesulphonate dioxygenase activity
GO:0018627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzenesulfonate dioxygenase activity
RHEA:59107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate <=> a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)
RHEA:40921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O
REACT:R-CFA-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Canis familiaris)
RHEA:37381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
RHEA:23466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine
GO:0016664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With an iron-sulfur protein as acceptor"
GO:0016664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor
GO:0016664	skos:prefLabel	"With an iron-sulfur protein as acceptor"
GO:0016664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor
REACT:R-SCE-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Saccharomyces cerevisiae)
REACT:R-RNO-166792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C2 into C2a and C2b (Rattus norvegicus)
RHEA:26321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"resorcinol O-methyltransferase"
RHEA:26321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	resorcinol + S-adenosyl-L-methionine = 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine
RHEA:26321	skos:altLabel	"O-methyltransferase 12"
RHEA:26321	skos:prefLabel	"resorcinol O-methyltransferase"
GO:0016651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on NAD(P)H
GO:0016651	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on NADH or NADPH, other acceptor
GO:0016651	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, acting on NADH or NADPH
GO:0016651	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NAD(P)H dehydrogenase
REACT:R-SSC-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)
REACT:R-DRE-1861595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extension of pseudopodia by myosin-X in a PI3K dependent manner (Danio rerio)
REACT:R-HSA-444498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin-releasing hormone receptor binds thyrotropin (Homo sapiens)
REACT:R-PFA-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)
REACT:R-DDI-9706399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 hydrolyzes ATP (Dictyostelium discoideum)
GO:0047400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphonoacetate phosphonohydrolase activity
GO:0047400	skos:prefLabel	"phosphonoacetate hydrolase"
GO:0047400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphonoacetate hydrolase activity
GO:0047400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphonoacetate = acetate + H(+) + phosphate
GO:0047400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphonoacetate hydrolase"
REACT:R-SSC-5654592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)
REACT:R-BTA-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Bos taurus)
RHEA:52544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythronate + NAD(+) = 2-dehydro-D-erythronate + H(+) + NADH
RHEA:52544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-erythronate 2-dehydrogenase"
RHEA:52544	skos:prefLabel	"D-erythronate 2-dehydrogenase"
REACT:R-XTR-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Xenopus tropicalis)
GO:0018574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
GO:0031729	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR4 chemokine receptor ligand
GO:0031729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR4 chemokine receptor binding
RHEA:32263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + pyruvate = L-alanine + succinate semialdehyde
RHEA:37412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklavinone + NADP(+) => aklaviketone + 2 H(+) + NADPH
REACT:R-DDI-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)
REACT:R-HSA-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)
REACT:R-CFA-8877813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND5A,B exchange GTP for GDP on RAB39 (Canis familiaris)
RHEA:23082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-rhamnonate + H2O => L-rhamnonate
REACT:R-CFA-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Canis familiaris)
REACT:R-SSC-209792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylation of serotonin (Sus scrofa)
EC:1.14.14.134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-amyrin 24-hydroxylase"
EC:1.14.14.134	skos:altLabel	"sophoradiol 24-hydroxylase"
EC:1.14.14.134	skos:altLabel	"CYP93E1"
EC:1.14.14.134	skos:prefLabel	"beta-amyrin 24-hydroxylase"
RHEA:55164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 = H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)
RHEA:45085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-112156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters (Homo sapiens)
REACT:R-GGA-265426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Tenascin (Gallus gallus)
REACT:R-BTA-5675456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer (Bos taurus)
REACT:R-RNO-4551724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 (Rattus norvegicus)
RHEA:34010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrodesmosterol + S-adenosyl-L-methionine <=> 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine
RHEA:32737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine
REACT:R-CFA-2161964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Canis familiaris)
REACT:R-CFA-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Canis familiaris)
REACT:R-HSA-1028812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of interferon-beta (Homo sapiens)
REACT:R-GGA-211186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DFF45 (224) by caspase-3 (Gallus gallus)
REACT:R-RNO-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Rattus norvegicus)
RHEA:66963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
REACT:R-BTA-9033509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5L (Bos taurus)
GO:0051880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-quadruplex DNA binding
GO:0051880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-quartet DNA binding
GO:0051880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-DNA binding
GO:0051880	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	G-quartet binding
GO:0051880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G quadruplex DNA binding
GO:0051880	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	G quartet binding
GO:0051880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quadruplex DNA binding
GO:0051880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetraplex DNA binding
GO:0051880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G quartet DNA binding
RHEA:23883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + phosphoenolpyruvate <=> N(pros)-phospho-L-histidyl-[protein] + pyruvate
RHEA:35566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-hexadecenoyl) ethanolamine <=> (9Z)-hexadecenoate + ethanolamine
RHEA:45686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-dodecanoyl-sphing-4-enine-1-phosphate(out) => N-dodecanoyl-sphing-4-enine-1-phosphate(in)
REACT:R-DRE-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Danio rerio)
RHEA:66520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Danio rerio)
RHEA:42263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptanoyl-CoA + malonyl-[ACP] <=> 3-oxononanoyl-[ACP] + CO2 + CoA
RHEA:19965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylpropiothetin dethiomethylase"
RHEA:19965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)
RHEA:19965	skos:prefLabel	"dimethylpropiothetin dethiomethylase"
REACT:R-SCE-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Saccharomyces cerevisiae)
REACT:R-HSA-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Homo sapiens)
REACT:R-DRE-4655355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Danio rerio)
RHEA:27316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+) => dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2
REACT:R-RNO-2454208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta and gamma subunits by LYN (Rattus norvegicus)
GO:0051539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe 4 S cluster binding
GO:0051539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 iron, 4 sulfur cluster binding
GO:0051539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrairon tetrasulfide cluster binding
GO:0051539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrairon tetrasulphide cluster binding
GO:0051539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulfur cluster 4Fe-4S binding
GO:0051539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 iron, 4 sulphur cluster binding
GO:0051539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4Fe-4S cluster binding
GO:0051539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulphur cluster 4Fe-4S binding
REACT:R-GGA-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)
REACT:R-DDI-451418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates IRAK1 (Dictyostelium discoideum)
REACT:R-MMU-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)
RHEA:52974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]
RHEA:35354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H(+) + NADPH
REACT:R-DDI-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Dictyostelium discoideum)
REACT:R-SSC-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Sus scrofa)
REACT:R-MMU-8851908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 (Mus musculus)
RHEA:43649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + CoA
REACT:R-DME-8869607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NAR to yield NAMN (Drosophila melanogaster)
GO:0062076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA delta(5)-desaturase activity
GO:0062076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA (8-3)-desaturase"
GO:0062076	skos:prefLabel	"acyl-CoA (8-3)-desaturase"
GO:0062076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA D5-desaturase activity
GO:0062076	skos:altLabel	"acyl-CoA 5-desaturase (methylene-interrupted)"
GO:0062076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA delta5-desaturase activity
GO:0062076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA (8-3)-desaturase
REACT:R-HSA-5617829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of IFT A complex (Homo sapiens)
RHEA:21457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-diazo-5-oxo-L-norleucine + acetyl-CoA <=> CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine
REACT:R-CEL-3341277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)
REACT:R-CFA-388830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds ICOS (Canis familiaris)
RHEA:69224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-alkenyl glucosinolate + H2O = a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)
GO:0030374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear receptor transcription coactivator activity
GO:0030374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-activated RNA polymerase II transcription factor binding transcription factor activity
GO:0030374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
GO:0030374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-dependent nuclear receptor transcription co-activator activity
GO:0030374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear receptor coactivator activity
GO:0030374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-dependent nuclear receptor transcription coactivator activity
REACT:R-HSA-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Homo sapiens)
RHEA:72916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructopyranose(out) + Na(+)(out) => D-fructopyranose(in) + Na(+)(in)
REACT:R-MMU-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)
GO:0010284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lariciresinol reductase activity
RHEA:70891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(out) + L-glutamine(in) + Na(+)(out) = L-asparagine(in) + L-glutamine(out) + Na(+)(in)
REACT:R-MMU-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Mus musculus)
REACT:R-XTR-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Xenopus tropicalis)
REACT:R-CEL-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
REACT:R-BTA-188002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rab5-mediated recruitment of class III PI3K to TLR9 (Bos taurus)
REACT:R-SSC-450257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Sus scrofa)
REACT:R-DME-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Drosophila melanogaster)
REACT:R-XTR-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Xenopus tropicalis)
RHEA:48955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) <=> 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH
REACT:R-BTA-2395322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyridinoline cross-links (Bos taurus)
REACT:R-BTA-2197770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1 (FEEL-1) binds ligands (Bos taurus)
RHEA:26064	skos:altLabel	"hygromycin-B kinase"
RHEA:26064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hygromycin B = 4-O-phosphohygromycin B + ADP + H(+)
RHEA:26064	skos:prefLabel	"hygromycin B 4-O-kinase"
RHEA:26064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hygromycin B 4-O-kinase"
REACT:R-DRE-2395764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atREs binds to nascent CM (Danio rerio)
RHEA:72014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(in) + urate(out) <=> glutathione(out) + urate(in)
REACT:R-BTA-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Bos taurus)
REACT:R-DRE-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Danio rerio)
REACT:R-DRE-1358789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Self-ubiquitination of RNF41 (Danio rerio)
REACT:R-CEL-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Caenorhabditis elegans)
REACT:R-GGA-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Gallus gallus)
REACT:R-CEL-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:32197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-al + H2O => abieta-7,13-dien-18,18-diol
RHEA:65943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + GDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)
RHEA:39987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
REACT:R-DRE-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Danio rerio)
RHEA:66946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B
REACT:R-CFA-5654672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR1 (Canis familiaris)
REACT:R-CFA-426489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC binds inexactly matching target RNAs (Canis familiaris)
RHEA:30528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => ADP + ATP + 2 H(+)
REACT:R-HSA-2028294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Homo sapiens)
REACT:R-BTA-6791227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Bos taurus)
RHEA:11699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-demethylstaurosporine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + staurosporine
RHEA:49195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
RHEA:33090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic dehypoxanthinylfutalosinate <=> 1,4-dihydroxy-6-naphthoate + chemical entity
RHEA:33234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + heme b <=> heme d cis-diol
RHEA:35233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin(out) => rifampicin(in)
REACT:R-DDI-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)
REACT:R-DDI-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Dictyostelium discoideum)
RHEA:68855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (1S,6S,7R)-sesquipiperitol + diphosphate
REACT:R-CEL-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Caenorhabditis elegans)
RHEA:28015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + thiocyanate => methyl thiocyanate + S-adenosyl-L-homocysteine
RHEA:66639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (-)-alpha-acorenol + diphosphate
RHEA:30871	skos:prefLabel	"deoxyribokinase"
RHEA:30871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose + ATP = 2-deoxy-D-ribose 5-phosphate + ADP + H(+)
RHEA:30871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyribokinase"
REACT:R-SCE-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Saccharomyces cerevisiae)
RHEA:12582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + pyruvate + taurine => H2O + NAD(+) + tauropine
RHEA:40050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trioctanoylglycerol + H2O <=> 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate
RHEA:37293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + L-leucine => H2O + L-alanyl-L-leucine
RHEA:63234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADH
REACT:R-SSC-8953115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds to MGA:MAX (Sus scrofa)
RHEA:35792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine => H(+) + kanamycin X + UDP
RHEA:71984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene B
RHEA:11439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 <=> 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O
REACT:R-PFA-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Plasmodium falciparum)
REACT:R-BTA-5576895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-RNO-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)
REACT:R-HSA-947673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanin-concentrating hormone receptors bind MCH (Homo sapiens)
RHEA:20739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + glycine <=> (2S)-2-amino-3-oxobutanoate + CoA
RHEA:21959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vitexin <=> H(+) + UDP + vitexin 2''-O-beta-D-glucoside
RHEA:20490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)
GO:0050622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine dehydrogenase (cyanide-forming) activity
GO:0050622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HCN synthase activity
GO:0050622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + glycine = 2 AH2 + CO2 + hydrogen cyanide
GO:0050622	skos:altLabel	"hydrogen cyanide synthase"
GO:0050622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)
GO:0050622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine dehydrogenase (cyanide-forming)"
GO:0050622	skos:altLabel	"HCN synthase"
GO:0050622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen cyanide synthase activity
GO:0050622	skos:prefLabel	"glycine dehydrogenase (cyanide-forming)"
REACT:R-RNO-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Rattus norvegicus)
RHEA:63556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynorphin A-(1-13) + H2O = dynorphin A-(1-12) + L-lysine
REACT:R-SSC-2130393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex along Golgi to TGN (Sus scrofa)
REACT:R-SCE-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)
REACT:R-DRE-443418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b signaling involves c-Src (Danio rerio)
REACT:R-DRE-6800490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates PIDD1 (Danio rerio)
REACT:R-SSC-8937631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Sus scrofa)
RHEA:70076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine => A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine
REACT:R-DME-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Drosophila melanogaster)
REACT:R-SSC-140736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Sus scrofa)
REACT:R-BTA-977605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H displaces Bb (Bos taurus)
RHEA:35260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate
RHEA:41411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine
RHEA:69729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + phenylacetyl-AMP => 2-phenylacetate + ATP + H(+)
REACT:R-BTA-8934465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds PTPN12 (Bos taurus)
GO:0004320	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oleoyl-ACP thioesterase activity
GO:0004320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleoyl-[acyl-carrier protein] hydrolase activity
GO:0004320	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oleoyl-acyl carrier protein thioesterase activity
GO:0004320	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	oleoyl-acyl-carrier-protein hydrolase
GO:0004320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleoyl-ACP hydrolase activity
GO:0004320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleoyl-[acyl-carrier-protein] hydrolase activity
EC:3.4.21.120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oviductin"
EC:3.4.21.120	skos:altLabel	"ovochymase-2"
EC:3.4.21.120	skos:prefLabel	"oviductin"
EC:3.4.21.120	skos:altLabel	"oviductal protease"
RHEA:64567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-epi-ilicicolin H <=> ilicicolin H
REACT:R-CEL-352379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Caenorhabditis elegans)
REACT:R-CFA-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Canis familiaris)
REACT:R-MMU-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Mus musculus)
REACT:R-MMU-189208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Mus musculus)
REACT:R-BTA-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Bos taurus)
RHEA:55495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea(in) => urea(out)
REACT:R-CFA-9645524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose binds TIFA (Canis familiaris)
REACT:R-SSC-8959462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Sus scrofa)
RHEA:48472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1a + H2O = ganglioside GD1a + N-acetylneuraminate
REACT:R-BTA-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Bos taurus)
RHEA:53142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SPO-8955010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRTOMT transfers Met to DA, forming 3MT (Schizosaccharomyces pombe)
REACT:R-DME-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
REACT:R-DRE-4551661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates RNF168 with SUMO1 (Danio rerio)
REACT:R-SSC-209921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoiodinated tyrosine can be deiodinated (Sus scrofa)
RHEA:63649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:47192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] = Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M
RHEA:37421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
GO:0090353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polygalacturonase inhibitor activity
REACT:R-BTA-9709360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 reduces MetHb (Bos taurus)
REACT:R-MMU-8864595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2B homodimer binds YEATS4 (Mus musculus)
RHEA:32342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-thujan-3-ol + NADP(+) <=> (+)-thujan-3-one + H(+) + NADPH
REACT:R-RNO-9009526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Rattus norvegicus)
RHEA:16071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + uridine => cytidine + H(+) + H2O
REACT:R-MMU-1169398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host protein filamin B (Mus musculus)
RHEA:29531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase"
RHEA:29531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:29531	skos:prefLabel	"dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase"
RHEA:29531	skos:altLabel	"Dol-P-Man:Man6GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase"
REACT:R-BTA-380869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked dopamine loaded synaptic vesicle (Bos taurus)
GO:0023030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class Ib protein binding, via antigen binding groove
REACT:R-HSA-6790025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of BCL2, BCL2L1 (Homo sapiens)
REACT:R-CEL-6785933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT8 transfers Gal from UDP-Gal to CERA (Caenorhabditis elegans)
REACT:R-CFA-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)
REACT:R-SPO-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Schizosaccharomyces pombe)
REACT:R-DDI-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Dictyostelium discoideum)
REACT:R-HSA-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)
REACT:R-RNO-8862137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B2 oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)
GO:0008903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxypyruvate aldose-ketose-isomerase activity
GO:0008903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxypyruvate isomerase activity
GO:0008903	skos:prefLabel	"hydroxypyruvate isomerase"
GO:0008903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate
GO:0008903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxypyruvate isomerase"
GO:0008903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxypyruvate ketol-isomerase activity
REACT:R-CFA-9707186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 binds ALOX5 inhibitors (Canis familiaris)
REACT:R-SSC-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Sus scrofa)
RHEA:29134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + nitrate <=> H2O + menaquinone-8 + nitrite
REACT:R-RNO-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Rattus norvegicus)
REACT:R-DME-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Drosophila melanogaster)
REACT:R-SPO-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Schizosaccharomyces pombe)
RHEA:46711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] <=> AMP + H(+) + salicyl-[non-ribosomal peptide synthase]
RHEA:58537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoylglycine
RHEA:28072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + Fe(II)-heme o => (2E,6E)-farnesyl diphosphate + H2O + heme b
REACT:R-DME-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)
GO:0052836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 5-diphosphate pentakisphosphate 5-kinase activity
REACT:R-RNO-8853734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Rattus norvegicus)
REACT:R-DME-5625745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 stimulates association of AR with NCOA2 (Drosophila melanogaster)
RHEA:31400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diapophytofluene + FAD + H(+) => all-trans-4,4'-diapo-zeta-carotene + FADH2
GO:0010277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a oxygenation activity
GO:0010277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a oxygenase [overall] activity
GO:0010277	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CAO activity
GO:0010277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorophyllide-a oxygenation activity
GO:0010277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll b synthesis activity
GO:0010277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorophyll-b synthesis activity
GO:0010277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorophyllide a:oxygen 7-oxidoreduction activity
REACT:R-DME-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Drosophila melanogaster)
REACT:R-BTA-193700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR ICD signals to NF-kB (Bos taurus)
REACT:R-BTA-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Bos taurus)
REACT:R-MMU-163320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of mTERF with the termination sequence (Mus musculus)
REACT:R-MMU-5654582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates SHC1 (Mus musculus)
RHEA:14442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + gentamicin C => CoA + H(+) + N(3)-acetylgentamycin C
REACT:R-DME-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
REACT:R-CFA-8961021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD binds with itself to form SFTPD 12mer (Canis familiaris)
REACT:R-SSC-4608852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 ubiquitinates PRICKLE1 (Sus scrofa)
RHEA:20053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + ribitol = D-ribulose + H(+) + NADH
RHEA:20053	skos:prefLabel	"ribitol 2-dehydrogenase"
RHEA:20053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribitol 2-dehydrogenase"
REACT:R-GGA-9647632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDME (Gallus gallus)
RHEA:28642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> (-)-gamma-cadinene + diphosphate
RHEA:58684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 H(+) + NADPH + O2 = FADH2-C4alpha-hydroperoxide + NADP(+)
REACT:R-HSA-201821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
REACT:R-DRE-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Danio rerio)
REACT:R-RNO-2730892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV to p-SLP-76 (Rattus norvegicus)
RHEA:19712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA
RHEA:47690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH => cis-4-hydroxy-L-proline + NADP(+)
REACT:R-XTR-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Xenopus tropicalis)
REACT:R-DME-9029690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-6 translocates to the nucleus (Drosophila melanogaster)
REACT:R-BTA-6809320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Bos taurus)
REACT:R-SSC-265427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Sus scrofa)
REACT:R-MMU-420173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR1,CRHR2-1 binds CRH,UCN (Mus musculus)
RHEA:21563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol <=> 1,4-dithiothreitol + 2,3-epoxyphylloquinone
EC:1.1.1.417	skos:prefLabel	"3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)"
EC:1.1.1.417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)"
REACT:R-HSA-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Homo sapiens)
RHEA:10581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate
REACT:R-XTR-8938773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A polyubiquitinates PRKDC (Xenopus tropicalis)
REACT:R-MMU-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Mus musculus)
REACT:R-SSC-8870732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSGs bind proteoglycans and TGF-beta1 (Sus scrofa)
REACT:R-CFA-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Canis familiaris)
REACT:R-HSA-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Homo sapiens)
REACT:R-MMU-6811472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IER3 recruits MAPKs to PP2A-B56-beta,gamma (Mus musculus)
REACT:R-HSA-1614665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQR oxidizes sulfide to bound persulfide (Homo sapiens)
RHEA:17572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + NADP(+) <=> 1,2-dehydroreticuline + H(+) + NADPH
REACT:R-XTR-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Xenopus tropicalis)
REACT:R-DRE-71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)
REACT:R-HSA-2022141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolysyl oxidase activation (Homo sapiens)
REACT:R-CFA-5690785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds Ub-HCFC1 (Canis familiaris)
RHEA:22249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) => 7,8-dihydroxykynurenate + H(+) + NADH
REACT:R-GGA-8964241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta-gamma complex and PIP3 recruit BTK to membrane (Gallus gallus)
RHEA:12314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+) => dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2
GO:0004061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formamidase II
GO:0004061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylase activity
GO:0004061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylkynurenine formamidase activity
GO:0004061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylkynureninase activity
GO:0004061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-formylamine amidohydrolase activity
GO:0004061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formamidase I
GO:0004061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenine formamidase activity
GO:0004061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylformamidase activity
REACT:R-SSC-8983841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 associates with IL6ST:IL6ST (Sus scrofa)
RHEA:43888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine = [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine
RHEA:48241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1b => CMP + ganglioside GT1b + H(+)
RHEA:30272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (3,4-dimethoxyphenyl)methanol + H2O2 => 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O
GO:0047983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-alanine specific hGSH synthetase activity
GO:0047983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoglutathione synthetase activity
GO:0047983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)
GO:0047983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homoglutathione synthase activity
REACT:R-GGA-6799722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 oxidoreductase generates unstable semiquinones (Gallus gallus)
REACT:R-DRE-8863973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of ERC and phagosome (Danio rerio)
GO:0099038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide floppase activity
GO:0099038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP-dependent ceramide transporter activity
GO:0099038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide floppase activity (cytosolic to exoplasmic leaftlet)
GO:0099038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-coupled ceramide transporter activity
GO:0099038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ceramide-translocating ATPase activity
REACT:R-XTR-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Xenopus tropicalis)
GO:0102756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-long-chain 3-ketoacyl-CoA synthase activity
RHEA:51248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate
RHEA:22825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + uracil
REACT:R-XTR-4568863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RAD52 with SUMO1 (Xenopus tropicalis)
REACT:R-MMU-204850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Dok-2 (Mus musculus)
RHEA:21283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 O2 + thiamine <=> H(+) + 2 H2O2 + thiamine acetate
RHEA:55170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)
RHEA:39555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)
REACT:R-MTU-879266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycothiol is oxidized to mycothione (Mycobacterium tuberculosis)
REACT:R-DRE-508308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Danio rerio)
REACT:R-DME-164834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enzyme-bound ATP is released (Drosophila melanogaster)
REACT:R-HSA-5634221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)
RHEA:25439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (E,R)-alpha-bisabolene + diphosphate
RHEA:40586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanedioyl-CoA <=> CoA + H(+) + hexanedioate
REACT:R-DRE-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Danio rerio)
RHEA:39059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-1234173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)
RHEA:11482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + H2O + NADP(+) => 3-hydroxybenzoate + H(+) + NADPH + O2
REACT:R-CEL-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Caenorhabditis elegans)
REACT:R-CEL-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Caenorhabditis elegans)
REACT:R-CFA-8855564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Canis familiaris)
REACT:R-DRE-9759202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Danio rerio)
REACT:R-SSC-5690827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 (Sus scrofa)
REACT:R-MMU-6794355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 binds mGluR1a,5 (Mus musculus)
RHEA:71872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxybutanoate(out) + H(+)(out) => (S)-3-hydroxybutanoate(in) + H(+)(in)
RHEA:18245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + ATP = ADP + CoA + H(+)
RHEA:18245	skos:prefLabel	"dephospho-CoA kinase"
RHEA:18245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dephospho-CoA kinase"
RHEA:18245	skos:altLabel	"dephosphocoenzyme A kinase"
REACT:R-CFA-444047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR3 binds carboxylates (Canis familiaris)
RHEA:65171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + preaustinoid A <=> A + H2O + preaustinoid A1
REACT:R-DDI-198440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Dictyostelium discoideum)
RHEA:43064	skos:prefLabel	"monacolin J acid methylbutanoate transferase"
RHEA:43064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monacolin J acid methylbutanoate transferase"
RHEA:43064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate = holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate
RHEA:59146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate => 10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
REACT:R-BTA-5223305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL, inhibiting it (Bos taurus)
REACT:R-MMU-9024766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Mus musculus)
RHEA:67603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O(6)-methyl-dGTP <=> diphosphate + H(+) + O(6)-methyl-dGMP
REACT:R-SSC-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Sus scrofa)
REACT:R-MMU-9700121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN,MDK):PTPRZ oligomerizes (Mus musculus)
REACT:R-GGA-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Gallus gallus)
RHEA:49457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + H2O => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate
REACT:R-CFA-167433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta-gamma subunits rebind the alpha-GDP subunit (Canis familiaris)
REACT:R-RNO-8941613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
RHEA:39307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH = (11Z,14Z)-eicosadienoyl-CoA + NADP(+)
RHEA:51903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine <=> acetate + spermidine
REACT:R-MMU-158849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phenol can form a sulfate conjugate (Mus musculus)
RHEA:62593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH
REACT:R-HSA-2396399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillins bind BMPs (Homo sapiens)
REACT:R-SCE-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Saccharomyces cerevisiae)
REACT:R-RNO-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Rattus norvegicus)
GO:0030215	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plexin ligand
GO:0030215	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	semaphorin receptor ligand
GO:0030215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	semaphorin receptor binding
GO:0030215	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plexin binding
RHEA:43683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:36992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + UMP => alpha-D-ribose 1,5-bisphosphate + uracil
REACT:R-GGA-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Gallus gallus)
GO:0033454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine tRNA
GO:0033454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCC codon-amino acid adaptor activity
RHEA:31334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + molybdopterin <=> adenylyl-molybdopterin + diphosphate
RHEA:22946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-pregnan-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5beta-pregnane-20-one + NADP(+)
REACT:R-HSA-416320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR1-containing  AMPA receptors (Homo sapiens)
REACT:R-SSC-2467811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of sister chromatids (Sus scrofa)
REACT:R-BTA-202723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha5beta1 binds FN1 dimer (Bos taurus)
REACT:R-DME-421833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Drosophila melanogaster)
REACT:R-SSC-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Sus scrofa)
RHEA:38785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:12458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-L-ribitol + diphosphate => CTP + D-ribitol 5-phosphate + H(+)
REACT:R-HSA-416546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Homo sapiens)
REACT:R-SSC-211910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Sus scrofa)
REACT:R-BTA-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
RHEA:39868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol => 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)
REACT:R-DRE-2467809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESPL1 (Separase) cleaves centromeric cohesin (Danio rerio)
REACT:R-RNO-139917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAX protein (Rattus norvegicus)
REACT:R-CEL-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Caenorhabditis elegans)
RHEA:30332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-750993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (q) reassociates with G beta:gamma (Xenopus tropicalis)
RHEA:39628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O
REACT:R-RNO-5218830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates PTK2-beta (Rattus norvegicus)
RHEA:25107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyridoxamine <=> ADP + H(+) + pyridoxamine 5'-phosphate
EC:1.6.99.n1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADPH dehydrogenase (coenzyme F420 dependent)"
EC:1.6.99.n1	skos:altLabel	"NADP reductase (coenzyme F420 dependent)"
EC:1.6.99.n1	skos:altLabel	"F420-dependent NADP reductase"
EC:1.6.99.n1	skos:prefLabel	"NADPH dehydrogenase (coenzyme F420 dependent)"
RHEA:17018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA => (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA
GO:0042933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrysobactin transmembrane transporter activity
GO:0042933	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chrysobactin transporter activity
GO:0004488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0004488	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:NADP oxidoreductase activity
GO:0004488	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity
RHEA:19915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxoacyl-[ACP] + H(+) + NADH => a (3R)-hydroxyacyl-[ACP] + NAD(+)
REACT:R-DDI-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Dictyostelium discoideum)
RHEA:22140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 5'-phosphate + H2O = a nucleoside + phosphate
GO:0140769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP-dependent peptidyl-lysine N6-myristoyltransferase activity
GO:0140769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]
RHEA:54645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline => (S)-1-pyrroline-5-carboxylate + H(+) + H2O
REACT:R-HSA-9692131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOX9 binds the FGF9 gene (Homo sapiens)
REACT:R-SSC-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Sus scrofa)
REACT:R-CFA-203070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of profilin with monomeric actin (Canis familiaris)
REACT:R-RNO-9706287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to ABL2 (Rattus norvegicus)
RHEA:16504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-1D-myo-inositol <=> H(+) + myo-inositol + sn-glycerol 3-phosphate
REACT:R-SSC-9647746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 trimerizes (Sus scrofa)
REACT:R-HSA-9756169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)
REACT:R-HSA-5628871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 promotes EP300-mediated acetylation of TP53 (Homo sapiens)
REACT:R-CFA-77609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of APOBEC-1 to form editosome (Canis familiaris)
REACT:R-CEL-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Caenorhabditis elegans)
REACT:R-CFA-2203479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2 (FEEL-2) binds ligands (Canis familiaris)
REACT:R-BTA-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Bos taurus)
RHEA:11638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin E1 + H(+) + NADPH => NADP(+) + prostaglandin E1
REACT:R-RNO-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Rattus norvegicus)
RHEA:51609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + pyruvate => (R)-lactate + 2-oxoglutarate
REACT:R-RNO-2404137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)
REACT:R-BTA-936963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization (Bos taurus)
RHEA:68312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O = 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate
REACT:R-BTA-9708536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 translocates from the cytosol to the nucleoplasm (Bos taurus)
REACT:R-GGA-6788385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of ATR and ATRIP is recruited to ICL-DNA (Gallus gallus)
RHEA:17995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate => ATP + beta-alanine + gamma-L-glutamyl-L-cysteine
REACT:R-MMU-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Mus musculus)
REACT:R-RNO-8851866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds RANBP10 (Rattus norvegicus)
REACT:R-BTA-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Bos taurus)
RHEA:67212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2
RHEA:40577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glutarate + H(+) => glutaryl-CoA + H2O
REACT:R-HSA-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Homo sapiens)
REACT:R-CFA-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Canis familiaris)
REACT:R-BTA-73729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of SL1 (Bos taurus)
REACT:R-MMU-5651654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Mus musculus)
RHEA:67798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA => a ribonucleotidyl-ribonucleotide-RNA
GO:0017002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activin-activated receptor activity
GO:0017002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activin receptor activity
RHEA:26556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin-(1-7) + L-phenylalanine => angiotensin II + H2O
EC:3.4.23.28	skos:altLabel	"Acrocylindrium proteinase"
EC:3.4.23.28	skos:prefLabel	"acrocylindropepsin"
EC:3.4.23.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acrocylindropepsin"
REACT:R-DRE-8987080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Danio rerio)
RHEA:44136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl dodecanoate
REACT:R-HSA-912291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorrectly folded glycoproteins translocate to the ERQC (Homo sapiens)
REACT:R-GGA-2559456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)
REACT:R-DME-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Drosophila melanogaster)
REACT:R-DME-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Drosophila melanogaster)
RHEA:31275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-2-methylpropanoate + NAD(+) = (S)-methylmalonate semialdehyde + H(+) + NADH
RHEA:62056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)
RHEA:58137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + H(+) => acetyl-AMP + diphosphate
REACT:R-BTA-6785165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Bos taurus)
REACT:R-RNO-5687183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKDC phosphorylates DCLRE1C at DNA DSBs (Rattus norvegicus)
RHEA:58343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O <=> chenodeoxycholate + D-glucose
REACT:R-HSA-8932184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HIGD1A (Homo sapiens)
REACT:R-GGA-8877311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB31 GEFs exchange GTP for GDP on RAB31 (Gallus gallus)
RHEA:59247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)
REACT:R-RNO-422454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polysialylation of NCAM1 (Rattus norvegicus)
REACT:R-SSC-9750555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Sus scrofa)
REACT:R-XTR-419003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Nectins with Afadin (Xenopus tropicalis)
RHEA:54871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-[ACP] + H(+) + NADH <=> butanoyl-[ACP] + NAD(+)
RHEA:72711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cathenamine + H(+) = 4,21-dehydrogeissoschizine
REACT:R-MMU-9014449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the plasma membrane (Mus musculus)
REACT:R-CFA-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Canis familiaris)
REACT:R-MMU-2168038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XV restin release (Mus musculus)
REACT:R-SSC-8857692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA demethylases demethylate N6-methyladenosine RNA (Sus scrofa)
REACT:R-DRE-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Danio rerio)
REACT:R-BTA-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Bos taurus)
RHEA:25928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylquinoline + A + H2O = 3-methylquinolin-2(1H)-one + AH2
RHEA:27461	skos:prefLabel	"D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase"
RHEA:27461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase"
RHEA:27461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glycero-alpha-D-manno-heptose
REACT:R-XTR-9629470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Xenopus tropicalis)
RHEA:46209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + eicosanoate => AMP + diphosphate + eicosanoyl-CoA
REACT:R-HSA-6808566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHGA-derived peptide binds the bacterial cell surface (Homo sapiens)
GO:0004623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidase activity
GO:0004623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lecithinase A activity
GO:0004623	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
GO:0004623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidolipase activity
GO:0004623	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
GO:0004623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase A2 activity
GO:0004623	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytosolic phospholipase A2 activity
GO:0004623	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	secreted phospholipase A2 activity
GO:0004623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylcholine 2-acylhydrolase activity
REACT:R-HSA-9035185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the NR1H3 gene (Homo sapiens)
RHEA:62642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycoredoxin]-L-disulfide + an alcohol + H2O => [mycoredoxin]-L-dithiol + a hydroperoxide
REACT:R-RNO-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Rattus norvegicus)
RHEA:59985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-acyl-L-glutamine + H2O => a carboxylate + L-glutamine
RHEA:47029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfo-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + sulfite
REACT:R-XTR-2230938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin:Haptoglobin:CD163 is endocytosed (Xenopus tropicalis)
RHEA:38751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate
RHEA:43115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelate + NAD(+) <=> H(+) + NADH + phenylglyoxylate
REACT:R-BTA-5654409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS2 (Bos taurus)
REACT:R-RNO-159771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein C to protein C (Rattus norvegicus)
RHEA:15776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dihydroxyacetone <=> ADP + dihydroxyacetone phosphate + H(+)
RHEA:71047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + L-phenylalanine(out) = glycine(out) + L-phenylalanine(in)
RHEA:63893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-tryptophan => AMP + D-tryptophan + diphosphate + H(+)
REACT:R-DME-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)
REACT:R-MMU-1307955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds HS:KLB:FGF19 (Mus musculus)
REACT:R-RNO-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Rattus norvegicus)
REACT:R-BTA-453339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)
REACT:R-DDI-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Dictyostelium discoideum)
RHEA:72603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + ATP + H(+) = (E)-sinapoyl-AMP + diphosphate
GO:0043802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)
GO:0043802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobB
GO:0043802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity
GO:0043802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity
REACT:R-RNO-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Rattus norvegicus)
REACT:R-HSA-5654408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS2 (Homo sapiens)
RHEA:44523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-HSA-166387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The FA anion diffuses away laterally from UCP (Homo sapiens)
REACT:R-GGA-4551738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO2,3 (Gallus gallus)
REACT:R-CFA-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Canis familiaris)
REACT:R-RNO-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Rattus norvegicus)
RHEA:46247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CEL-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)
RHEA:47661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-methionine sulfoximine => CoA + H(+) + N-acetyl-L-methionine sulfoximine
RHEA:31399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diapophytofluene + FAD + H(+) = all-trans-4,4'-diapo-zeta-carotene + FADH2
RHEA:46839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:54040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolathalia-3,7,11-triene synthase"
RHEA:54040	skos:prefLabel	"dolathalia-3,7,11-triene synthase"
RHEA:54040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = (3E,7E)-dolathalia-3,7,11-triene + diphosphate
REACT:R-XTR-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Xenopus tropicalis)
REACT:R-RNO-77274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Rattus norvegicus)
REACT:R-MMU-8848077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAP2 (Mus musculus)
REACT:R-GGA-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Gallus gallus)
REACT:R-RNO-5617182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates PLN (Rattus norvegicus)
RHEA:31683	skos:prefLabel	"prosolanapyrone-III cycloisomerase"
RHEA:31683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prosolanapyrone-III cycloisomerase"
RHEA:31683	skos:altLabel	"prosolanapyrone II oxidase/prosolanapyrone III cyclosiomerase"
RHEA:31683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prosolanapyrone III = (-)-solanapyrone A
RHEA:52355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SSC-2028724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind YAP1 (Sus scrofa)
REACT:R-HSA-73646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
REACT:R-BTA-3322429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP monoubiquinates TLE (Bos taurus)
REACT:R-DDI-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Dictyostelium discoideum)
REACT:R-MMU-380901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked serotonin loaded synaptic vesicle (Mus musculus)
REACT:R-RNO-77304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Rattus norvegicus)
REACT:R-HSA-5263633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DYSF, CAV3 and TRIM72 bind (Homo sapiens)
REACT:R-DRE-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Danio rerio)
RHEA:21274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathionylspermidine + H(+) + phosphate => ATP + glutathione + spermidine
RHEA:62385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic (2R)-2,3-bisphosphoglycerate + H2O => (2R)-2,3-bisphosphoglycerate + 2 H(+)
RHEA:22688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + H2O + O2 = H2O2 + NH4(+) + pyruvate
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	swivelase activity
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicking-closing enzyme activity
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	topoisomerase
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleate topoisomerase
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I DNA topoisomerase activity
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	untwisting enzyme activity
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	omega-protein activity
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA topoisomerase I activity
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	relaxing enzyme activity
GO:0003917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I topoisomerase activity
REACT:R-HSA-5419273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)
REACT:R-SSC-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Sus scrofa)
REACT:R-SSC-1793182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Sus scrofa)
GO:0051980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-nicotianamine transmembrane transporter activity
GO:0051980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-NA chelate transporter activity
REACT:R-HSA-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Homo sapiens)
REACT:R-BTA-8964271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in PIP3:BTK:G beta-gamma complex is activated (Bos taurus)
RHEA:13620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-methyl-5'-thioadenosine <=> 5-(methylsulfanyl)-D-ribose + adenine
RHEA:13130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-coumarate + UDP-alpha-D-glucose => 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP
RHEA:35513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:66572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-naphthol + 3'-phosphoadenylyl sulfate = 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-GGA-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Gallus gallus)
REACT:R-BTA-2730664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Bos taurus)
REACT:R-RNO-1855159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Rattus norvegicus)
RHEA:39419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)
RHEA:52848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Rattus norvegicus)
RHEA:29068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) + menaquinone-8 => CO2 + menaquinol-8
EC:1.14.99.54	skos:altLabel	"lytic polysaccharide monooxygenase"
EC:1.14.99.54	skos:prefLabel	"lytic cellulose monooxygenase (C1-hydroxylating)"
EC:1.14.99.54	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lytic cellulose monooxygenase (C1-hydroxylating)"
EC:1.14.99.54	skos:altLabel	"LPMO"
RHEA:12046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O
REACT:R-BTA-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Bos taurus)
REACT:R-DRE-914018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Danio rerio)
RHEA:36275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NADP(+)
RHEA:25640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + sulfoacetaldehyde <=> 2 H(+) + NADH + sulfoacetate
RHEA:16265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase"
RHEA:16265	skos:altLabel	"5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase"
RHEA:16265	skos:altLabel	"CYP98A3"
RHEA:16265	skos:prefLabel	"5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase"
RHEA:16265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate = 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-388468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR1A,B (Mus musculus)
RHEA:14865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + tyramine = H(+) + N-methyltyramine + S-adenosyl-L-homocysteine
RHEA:14865	skos:prefLabel	"tyramine N-methyltransferase"
RHEA:14865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyramine N-methyltransferase"
RHEA:67269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate => sch 210972
REACT:R-SSC-69562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Sus scrofa)
REACT:R-BTA-112435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin BC complex (Bos taurus)
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose 6-phosphate synthase activity
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-fructose phosphate glucosyltransferase activity
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-fructose-phosphate glucosyltransferase activity
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrosephosphate-UDP glucosyltransferase activity
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose phosphate-uridine diphosphate glucosyltransferase activity
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose-phosphate synthase activity
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SPS
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose phosphate synthetase activity
GO:0046524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-fructose-phosphate glucosyltransferase activity
REACT:R-GGA-9700171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates PLCG1 (Gallus gallus)
RHEA:36936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-1592240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NRF2 (Bos taurus)
REACT:R-BTA-9023632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Bos taurus)
REACT:R-CEL-77591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Caenorhabditis elegans)
RHEA:58529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + H2O + NADPH => (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)
RHEA:52254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine
REACT:R-CFA-9033516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Canis familiaris)
REACT:R-GGA-9613264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Gallus gallus)
REACT:R-CEL-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-MMU-4086392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Mus musculus)
REACT:R-HSA-163676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA (Homo sapiens)
REACT:R-CFA-2424481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
REACT:R-BTA-879377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Bos taurus)
REACT:R-RNO-176609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + PAPS => cholesterol sulfate + PAP (Rattus norvegicus)
REACT:R-DRE-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Danio rerio)
RHEA:12387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + O2 <=> H2O2 + uracil
RHEA:37714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-6798258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTPRF, PTPRS, PTPRD bind LRRC4B (Homo sapiens)
RHEA:44388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
RHEA:41004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine
RHEA:48505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-D-manno-heptose 1-phosphate + phosphate
REACT:R-BTA-190681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in endoplasmic reticulum membrane (Bos taurus)
RHEA:15267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate => 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate
REACT:R-HSA-8870732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)
RHEA:28938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> oxaloacetate + pyruvate
REACT:R-CFA-8877620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE2 cleaves EDN1(53-90) (Canis familiaris)
RHEA:67620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-3769393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ binds p-CBY:CTNNB1 (Drosophila melanogaster)
REACT:R-XTR-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Xenopus tropicalis)
RHEA:69953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:45639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
REACT:R-DRE-9708423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1:BACH1:Hemes are transported out of the nucleus (Danio rerio)
REACT:R-SSC-8952749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Sus scrofa)
REACT:R-MMU-8851436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFHR dimers bind C3b (Mus musculus)
RHEA:33865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + menaquinol-7 => menaquinone-7 + succinate
RHEA:29034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + 2 Na(+)(in) <=> L-glutamate(out) + 2 Na(+)(out)
REACT:R-MMU-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Mus musculus)
REACT:R-SSC-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Sus scrofa)
REACT:R-SSC-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Sus scrofa)
REACT:R-BTA-8987014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Bos taurus)
RHEA:48417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) => CMP + ganglioside GM2 (d18:1(4E)) + H(+)
REACT:R-MMU-192157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)
REACT:R-BTA-8964599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Bos taurus)
REACT:R-XTR-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Xenopus tropicalis)
REACT:R-MMU-5654672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR1 (Mus musculus)
REACT:R-RNO-6787540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUK phosphorylates beta-Fuc to Fuc1P (Rattus norvegicus)
GO:0002054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleobase binding
REACT:R-MMU-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Mus musculus)
REACT:R-DME-173545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Drosophila melanogaster)
RHEA:60794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A53 + 3 O2
REACT:R-DDI-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Dictyostelium discoideum)
RHEA:61893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)
REACT:R-DDI-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Dictyostelium discoideum)
REACT:R-RNO-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Rattus norvegicus)
REACT:R-HSA-418579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by P2Y purinoceptor 1 (Homo sapiens)
REACT:R-SSC-9700120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTN and MDK bind to PTPRZ (Sus scrofa)
REACT:R-CFA-168915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Canis familiaris)
REACT:R-HSA-3371567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBC1 is phosphorylated by ATM/ART (Homo sapiens)
REACT:R-HSA-977375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR1 binds C3bBb/C4bC2a (Homo sapiens)
RHEA:56379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)
RHEA:61396	skos:prefLabel	"protein-ribulosamine 3-kinase"
RHEA:61396	skos:altLabel	"ribulosamine 3-kinase"
RHEA:61396	skos:altLabel	"ribulosamine/erythrulosamine 3-kinase"
RHEA:61396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-ribulosamine 3-kinase"
RHEA:61396	skos:altLabel	"FN3K-related protein"
RHEA:61396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]
REACT:R-BTA-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Bos taurus)
RHEA:51179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-5654714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
REACT:R-DRE-8865107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MICAL1 produces NADP+, H2O2 (Danio rerio)
RHEA:15183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an acyl-CoA(in) + H(+) + phosphate => an acyl-CoA(out) + ATP + H2O
RHEA:59026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihexadecanoylglycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol
RHEA:60042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-methylhex-2-enoate + L-glutamine => H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate
REACT:R-CFA-9624800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LBR (Canis familiaris)
REACT:R-BTA-5693925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers L-fucose to Gal1,3GlcNAc (Bos taurus)
RHEA:58319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
REACT:R-CFA-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Canis familiaris)
REACT:R-HSA-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Homo sapiens)
REACT:R-HSA-5687520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MetAsp transforms to L-Asp,isoAsp (Homo sapiens)
RHEA:54183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + holo-[ACP] + NAD(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADH
REACT:R-SSC-2395340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxyallysine by LOX (Sus scrofa)
RHEA:31588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NADH + O2 + uracil => (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)
RHEA:72069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate => (2S)-2-aminobutanoate + ATP + L-glutamate
REACT:R-SSC-202174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ZAP-70 (Sus scrofa)
REACT:R-GGA-1236965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Export of peptide loaded MHC class I complex to PM (Gallus gallus)
REACT:R-XTR-266050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to LTC4 by LTC4S (Xenopus tropicalis)
REACT:R-MMU-4568914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of BLM with SUMO2,3 (Mus musculus)
REACT:R-HSA-5625784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)
REACT:R-MMU-209910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is taken up by thyroid epithelial cells (Mus musculus)
REACT:R-PFA-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Plasmodium falciparum)
REACT:R-SSC-109530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Sus scrofa)
RHEA:12940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
RHEA:20546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-kynurenine + NADPH + O2 => 3-hydroxy-L-kynurenine + H2O + NADP(+)
REACT:R-CFA-1022133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Canis familiaris)
REACT:R-DDI-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Dictyostelium discoideum)
REACT:R-SSC-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)
RHEA:17312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenyl acetate + H2O <=> a phenol + acetate + H(+)
REACT:R-BTA-2187309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer binds SP1 (Bos taurus)
REACT:R-MMU-8942344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 transports FOLA from extracellular region to cytosol (Mus musculus)
REACT:R-XTR-71286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)
REACT:R-MMU-2731122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2 & 4 bind VTN (Mus musculus)
RHEA:11354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + ADP => acetate + ATP
RHEA:31449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + CO2 + H2O => 6-amino-2-oxohexanoate + H2O2
REACT:R-SSC-170044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Sus scrofa)
RHEA:38876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2604) in 23S rRNA => pseudouridine(2604) in 23S rRNA
REACT:R-HSA-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)
RHEA:19431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[beta-adrenergic receptor]-phosphate + ADP + H(+) => [beta-adrenergic receptor] + ATP
RHEA:16492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-prunasin + H2O <=> D-glucose + mandelonitrile
GO:0015086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadmium ion transmembrane transporter activity
GO:0015086	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
GO:0015086	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc, cadmium uptake permease activity
REACT:R-DRE-209944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D binds GC (Danio rerio)
REACT:R-HSA-167150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)
REACT:R-MMU-210291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Mus musculus)
GO:0140839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain P3 isomerase activity
REACT:R-MMU-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Mus musculus)
REACT:R-HSA-913371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF receptor alpha:GM-CSF binds Bc (Homo sapiens)
REACT:R-SSC-5690157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP16,USP21 deubiquitinate Histone H2A (Sus scrofa)
REACT:R-RNO-210304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with PECAM1 (Rattus norvegicus)
RHEA:38903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate
REACT:R-GGA-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Gallus gallus)
REACT:R-MMU-5654641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)
RHEA:72033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapaldehyde + H2O2 => (E)-sinapyl alcohol + O2
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3PHP reductase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoglycerate:NAD+ 2-oxidoreductase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SerA 3PG dehydrogenase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoglycerate dehydrogenase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglyceric acid dehydrogenase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-phosphoglycerate:NAD+ oxidoreductase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-KG reductase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglycerate oxidoreductase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alphaKG reductase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SerA
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-phosphoglycerate dehydrogenase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerate 3-phosphate dehydrogenase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGDH activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglycerate dehydrogenase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D- and L-HGA
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-phosphoglycerate dehydrogenase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoglyceric acid dehydrogenase activity
GO:0004617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerate-1,3-phosphate dehydrogenase activity
RHEA:15979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + hydrogen cyanide => (S)-4-hydroxymandelonitrile
RHEA:20058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-carbamoylsarcosine => CO2 + NH4(+) + sarcosine
REACT:R-MMU-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Mus musculus)
RHEA:61475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + hexadecanoyl-CoA <=> an N-hexadecanoyl-sphingoid base + CoA + H(+)
REACT:R-CFA-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Canis familiaris)
REACT:R-BTA-9020282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Bos taurus)
REACT:R-SSC-5688786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds RAD23 (Sus scrofa)
REACT:R-SSC-194187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Sus scrofa)
RHEA:40703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-HSA-399941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rac1 binds PlexinA (Homo sapiens)
REACT:R-SSC-380901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked serotonin loaded synaptic vesicle (Sus scrofa)
RHEA:12139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) <=> a (2E,4E)-dienoyl-CoA + H(+) + NADPH
GO:0047279	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity
GO:0047279	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol 3-phosphate 1alpha-galactosyltransferase activity
GO:0047279	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity
GO:0047279	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity
GO:0047279	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity
GO:0047279	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isofloridoside-phosphate synthase activity
GO:0047279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol-3-phosphate 1-galactosyltransferase activity
GO:0047279	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity
RHEA:64986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:37872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 => 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)
REACT:R-CFA-9679045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR9 dimer binds HCQ (Canis familiaris)
REACT:R-GGA-9708517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Gallus gallus)
REACT:R-HSA-8950181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y693-STAT4 dimer translocates to the nucleus (Homo sapiens)
RHEA:69671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin 7-O-beta-D-glucoside + H2O = (2S)-naringenin + beta-D-glucose
RHEA:44104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH
REACT:R-HSA-3968414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Homo sapiens)
REACT:R-SSC-1604360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP14 (Sus scrofa)
GO:0033949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-FEH
GO:0033949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructan beta-(2,6)-fructosidase activity
GO:0033949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-(2,6)-fructan exohydrolase activity
GO:0033949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-(2,6)-D-fructan fructohydrolase activity
RHEA:49349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dihydroxyspirilloxanthin => 2-oxospirilloxanthin + H2O
GO:0047143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorate reductase activity
GO:0047143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorite:acceptor oxidoreductase activity
GO:0047143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorate reductase C
REACT:R-DRE-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)
REACT:R-SSC-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Sus scrofa)
RHEA:39617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA
GO:0022897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton-dependent peptide secondary active transmembrane transporter activity
GO:0022897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen/oligopeptide symporter
REACT:R-HSA-9022456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds 5mC-DNA (Homo sapiens)
RHEA:50040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
RHEA:60926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2
RHEA:62821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-9665278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resistant ERBB2 KD mutants do not bind AEE788 (Homo sapiens)
RHEA:15390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP => 3',5'-cyclic AMP + diphosphate
REACT:R-GGA-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Gallus gallus)
RHEA:61615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> 7-epi-cylindrospermopsin + CO2 + succinate
REACT:R-DRE-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Danio rerio)
RHEA:10015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2
RHEA:61485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-9012761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI binds RHOA-GDI (Canis familiaris)
RHEA:45204	skos:prefLabel	"methanol--corrinoid protein Co-methyltransferase"
RHEA:45204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol = H2O + methyl-Co(III)-[methanol-specific corrinoid protein]
RHEA:45204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methanol--corrinoid protein Co-methyltransferase"
RHEA:45204	skos:altLabel	"methanol--5-hydroxybenzimidazolylcobamide Co-methyltransferase"
RHEA:29628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltohexaose + beta-maltose => alpha-maltoheptaose + beta-D-glucose
REACT:R-RNO-205075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JNK phosphorylates BIM, BAD and other targets (Rattus norvegicus)
RHEA:24422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + N-terminal L-methionyl-[peptide] => H2O + N-terminal N-formyl-L-methionyl-[peptide]
REACT:R-CFA-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Canis familiaris)
RHEA:64271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	emodin anthrone + O2 <=> emodin + H(+) + H2O
RHEA:35933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-deamino-3''-hydroxykanamycin X + H(+) + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose
RHEA:33154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoamide + acetyl-CoA <=> (R)-S(6)-acetyldihydrolipoamide + CoA
REACT:R-XTR-9678766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 binds CYP3A4 inhibitors (Xenopus tropicalis)
REACT:R-DRE-1112690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds CBL (Danio rerio)
RHEA:72904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyrolactone II + dimethylallyl diphosphate => butyrolactone I + diphosphate
GO:0034632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinol transmembrane transporter activity
GO:0034632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin A1 transporter activity
GO:0034632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinol transporter activity
REACT:R-RNO-2161282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastic fibres bind associated proteins (Rattus norvegicus)
REACT:R-GGA-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Gallus gallus)
RHEA:19214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)
REACT:R-DRE-9029690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-6 translocates to the nucleus (Danio rerio)
REACT:R-CFA-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)
RHEA:52393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-erythronate => 4-phospho-D-erythronate + ADP + H(+)
REACT:R-HSA-9731393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA, EDNRB bind non-selective ERAs (Homo sapiens)
RHEA:16467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate => (R)-lactate + 2 Fe(III)-[cytochrome c553]
RHEA:21663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H2O + NADP(+) <=> benzoate + 2 H(+) + NADPH
GO:0061507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',5-3',5'-cyclic GMP-AMP binding
GO:0061507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclic GAMP binding
GO:0061507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c[G(2',5')pA(3',5')p] binding
GO:0061507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclic GMP-AMP binding
GO:0061507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP binding
GO:0061507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3' cGAMP binding
GO:0061507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3' cyclic GAMP binding
GO:0061507	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclic-GMP-AMP binding
REACT:R-DDI-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Dictyostelium discoideum)
REACT:R-HSA-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)
RHEA:37273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate => ATP + H2O + L-alanyl-L-glutamine(out)
REACT:R-XTR-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Xenopus tropicalis)
REACT:R-DRE-3343700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)
REACT:R-RNO-188979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Rattus norvegicus)
REACT:R-DRE-5649883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB-mediated DNA strand displacement synthesis (Danio rerio)
REACT:R-DME-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Drosophila melanogaster)
REACT:R-SSC-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)
REACT:R-CFA-141409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mad1 binds kinetochore (Canis familiaris)
REACT:R-MMU-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Mus musculus)
REACT:R-RNO-2022412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)
RHEA:11385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyoctadecanoate + NAD(+) => 2-oxooctadecanoate + H(+) + NADH
REACT:R-SSC-9632868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1B is phosphorylated in response to estrogen (Sus scrofa)
REACT:R-XTR-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Xenopus tropicalis)
RHEA:19631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CO2 + NADPH => D-threo-isocitrate + NADP(+)
RHEA:33406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonine <=> diphosphate + L-threonyl-5'-AMP
REACT:R-MMU-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Mus musculus)
REACT:R-GGA-9627106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) forms dimer (Gallus gallus)
RHEA:11193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (S)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)
REACT:R-HSA-399978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase C, alpha type phosphorylates MARCKS (Homo sapiens)
RHEA:20912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taxadiene synthase"
RHEA:20912	skos:altLabel	"taxa-4(5),11(12)-diene synthase"
RHEA:20912	skos:prefLabel	"taxadiene synthase"
RHEA:20912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene
RHEA:20912	skos:altLabel	"taxadiene cyclase"
RHEA:69797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate + H(+) + tRNA(Asp) => D-aspartyl-tRNA(Asp) + H2O
RHEA:33125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-tetraprenyl-beta-curcumene + diphosphate => all-trans-heptaprenyl diphosphate
RHEA:71720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) => H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)
RHEA:50635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O
REACT:R-HSA-947541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)
RHEA:29732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-maltose(in) => beta-maltose(out)
RHEA:22949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tagatofuranose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
REACT:R-RNO-211239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with chromatin (Rattus norvegicus)
RHEA:66125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-histidine => (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate
RHEA:37907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 = (8E,10S)-10-hydroperoxy-octadeca-8-enoate
RHEA:32335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-endo-fenchol + NADP(+) = (1S,4R)-fenchone + H(+) + NADPH
RHEA:37261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + H(+) + NADH + NH4(+) => (2S)-2-aminobutanoate + H2O + NAD(+)
REACT:R-BTA-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Bos taurus)
RHEA:24731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + H(+) => aniline + CO2
REACT:R-CFA-9702354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCA antibodies (Canis familiaris)
RHEA:12778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4-hydroxypteridine + O2 => 2-amino-4,7-dihydroxypteridine + chemical entity
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"undecaprenol kinase"
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + di-trans,octa-cis-undecaprenol = ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isoprenoid alcohol kinase (phosphorylating)
GO:0009038	skos:altLabel	"C55-isoprenoid alcohol kinase"
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenol kinase activity
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C55-isoprenoid alcohol kinase activity
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C55-isoprenoid alcohol phosphokinase activity
GO:0009038	skos:prefLabel	"undecaprenol kinase"
GO:0009038	skos:altLabel	"isoprenoid-alcohol kinase"
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isoprenoid alcohol kinase activity
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:undecaprenol phosphotransferase activity
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyisoprenol kinase activity
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C55-isoprenyl alcohol phosphokinase activity
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isoprenoid-alcohol kinase activity
GO:0009038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isoprenoid alcohol phosphokinase activity
REACT:R-HSA-392202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)
RHEA:29712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine(in) + H(+)(in) => cadaverine(out) + H(+)(out)
GO:0031715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5L2 anaphylatoxin chemotactic receptor binding
GO:0031715	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	C5L2 anaphylatoxin chemotactic receptor ligand
RHEA:47924	skos:prefLabel	"2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase"
RHEA:47924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase"
RHEA:47924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate = (2S)-3-sulfolactaldehyde + pyruvate
RHEA:47924	skos:altLabel	"KDSG aldolase"
REACT:R-CEL-163756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of fatty acid synthase (FAS) dimer (Caenorhabditis elegans)
REACT:R-SSC-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Sus scrofa)
REACT:R-DRE-71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)
GO:0072373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-carotene epsilon hydroxylase activity
RHEA:26156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose + NADP(+) = D-glucosone + H(+) + NADPH
RHEA:65258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + verruculide C epoxide => AH2 + O2 + verruculide C
RHEA:37774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-BTA-8878581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYRP1 oxidises DHICA to IQCA (Bos taurus)
REACT:R-RNO-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)
REACT:R-DDI-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Dictyostelium discoideum)
RHEA:16260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + phosphate <=> alpha-D-glucose + alpha-D-glucose 1-phosphate
RHEA:33626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + dodecanoate <=> AMP + diphosphate + dodecanoyl-CoA
RHEA:60157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-galactose(out) + H2O => ADP + D-galactose(in) + H(+) + phosphate
REACT:R-HSA-390886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH4 binds Hist (Homo sapiens)
REACT:R-RNO-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Rattus norvegicus)
RHEA:27506	skos:prefLabel	"cocaine esterase"
RHEA:27506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cocaine esterase"
RHEA:27506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cocaine + H2O = benzoate + ecgonine methyl ester + H(+)
RHEA:27506	skos:altLabel	"human carboxylesterase 2"
RHEA:28606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:28606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valine N-monooxygenase"
RHEA:28606	skos:prefLabel	"valine N-monooxygenase"
RHEA:28606	skos:altLabel	"CYP79D1"
RHEA:28606	skos:altLabel	"CYP79D2"
REACT:R-GGA-9021600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-proteins dissociate from plasma-membrane estrogen receptors (Gallus gallus)
REACT:R-SCE-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Saccharomyces cerevisiae)
REACT:R-SCE-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Saccharomyces cerevisiae)
REACT:R-CFA-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Canis familiaris)
REACT:R-DRE-3108209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO1 (Danio rerio)
REACT:R-GGA-4085217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Gallus gallus)
RHEA:23112	skos:altLabel	"6-methylsalicylate carboxy-lyase"
RHEA:23112	skos:prefLabel	"6-methylsalicylate decarboxylase"
RHEA:23112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylsalicylate + H(+) = 3-methylphenol + CO2
RHEA:23112	skos:altLabel	"6-MSA decarboxylase"
RHEA:23112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-methylsalicylate decarboxylase"
RHEA:36864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O
REACT:R-SCE-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Saccharomyces cerevisiae)
REACT:R-SSC-265422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaEbeta7 with Cadherin-1 (Sus scrofa)
REACT:R-DRE-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Danio rerio)
RHEA:50484	skos:prefLabel	"N-terminal methionine N(alpha)-acetyltransferase NatB"
RHEA:50484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-terminal methionine N(alpha)-acetyltransferase NatB"
RHEA:50484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]
REACT:R-RNO-5656070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFBPs bind FGFs (Rattus norvegicus)
RHEA:34338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Sus scrofa)
RHEA:44733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)
REACT:R-HSA-8856930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)
REACT:R-BTA-9012657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Bos taurus)
GO:0019975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-17 binding
GO:0019975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-17 binding
REACT:R-HSA-2731074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)
REACT:R-DRE-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Danio rerio)
RHEA:37529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA
RHEA:38625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA
REACT:R-HSA-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Homo sapiens)
REACT:R-CFA-5686398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPIDR binds BLM:TOP3A:RMI1:RMI2 (Canis familiaris)
REACT:R-DME-1181149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Drosophila melanogaster)
RHEA:36891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O
RHEA:59780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine
RHEA:55739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose <=> [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP
REACT:R-GGA-1236940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exogenous soluble antigen targeted to more stable early endosome (Gallus gallus)
RHEA:55610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base
REACT:R-DME-5686315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Drosophila melanogaster)
REACT:R-DRE-6788392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Danio rerio)
GO:0072545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyr binding
GO:0072545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine binding
REACT:R-HSA-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Homo sapiens)
RHEA:51135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a purine nucleobase
RHEA:68777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => diphosphate + germacrene A
RHEA:22907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-5649705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Dictyostelium discoideum)
REACT:R-HSA-9731051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 3b binds to RUNX1 (Homo sapiens)
RHEA:48735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O <=> [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine
RHEA:60242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2
REACT:R-XTR-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:56658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+)
RHEA:51542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:54892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
REACT:R-CFA-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)
REACT:R-DME-201648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, Endofin, recruits R-Smad1/5/8 (Drosophila melanogaster)
RHEA:42268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] = 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA
RHEA:47954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+) => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O
RHEA:19438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate + UDP-alpha-D-glucose => N-(beta-D-glucosyl)nicotinate + UDP
RHEA:62040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate
REACT:R-GGA-977071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Gallus gallus)
RHEA:48545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine
RHEA:67050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + asnovolin I + H2O => AH2 + chermesin D + O2
GO:0050641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)
GO:0050641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MSAS activity
GO:0050641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylsalicylic acid synthase activity
GO:0050641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-MSAS activity
RHEA:11968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + kynurenate + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + A
RHEA:11968	skos:prefLabel	"kynurenine 7,8-hydroxylase"
RHEA:11968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kynurenine 7,8-hydroxylase"
REACT:R-MMU-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Mus musculus)
RHEA:71166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanine(out) + Na(+)(out) <=> H(+)(out) + L-alanine(in) + Na(+)(in)
REACT:R-SCE-389756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT interacts and phosphorylates Cot (Saccharomyces cerevisiae)
RHEA:71992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate => (-)-astellatene + diphosphate
REACT:R-MMU-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Mus musculus)
REACT:R-DRE-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Danio rerio)
REACT:R-HSA-6805205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR35 binds kynurenic acid (Homo sapiens)
REACT:R-SPO-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)
REACT:R-XTR-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Xenopus tropicalis)
REACT:R-BTA-201790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)
REACT:R-BTA-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Bos taurus)
RHEA:50395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline <=> 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:71171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-cysteine(out) + Na(+)(out) = H(+)(out) + L-cysteine(in) + Na(+)(in)
RHEA:19650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + tRNA(Asp) => AMP + diphosphate + L-aspartyl-tRNA(Asp)
RHEA:47607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) <=> CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)
GO:0016721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on superoxide radicals as acceptor
GO:0016721	skos:prefLabel	"Acting on superoxide as acceptor"
GO:0016721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on superoxide as acceptor"
RHEA:65215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H2O <=> (2E)-dodecenoate + CoA + H(+)
REACT:R-HSA-9700168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates IRS1 (Homo sapiens)
REACT:R-XTR-909725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IRF9 with p-STAT2:p-STAT1 (Xenopus tropicalis)
REACT:R-HSA-1855168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 transports from the cytosol to the nucleus (Homo sapiens)
REACT:R-HSA-4719423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO3 (Homo sapiens)
REACT:R-BTA-5654631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PPTN11 (Bos taurus)
REACT:R-BTA-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Bos taurus)
REACT:R-CFA-3222259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF20 binds TP53 dimethylated on K370 and K382 (Canis familiaris)
RHEA:31821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-DDI-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)
RHEA:42728	skos:prefLabel	"21S rRNA (uridine(2791)-2'-O)-methyltransferase"
RHEA:42728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"21S rRNA (uridine(2791)-2'-O)-methyltransferase"
RHEA:42728	skos:altLabel	"mitochondrial rRNA MTase 2"
RHEA:42728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2791) in 21S rRNA = 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-6805205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR35 binds kynurenic acid (Xenopus tropicalis)
RHEA:17052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-9 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-9
REACT:R-RNO-1433451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds to p-KIT (Rattus norvegicus)
REACT:R-HSA-211583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Partial autophosphorylation of PAK-2 at  Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 (Homo sapiens)
RHEA:42270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA => 2-methylpropanoyl-CoA + H(+) + malonyl-[ACP]
REACT:R-MMU-9709406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to Cytochrome c oxidase (Mus musculus)
RHEA:37541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine
RHEA:12232	skos:prefLabel	"glycine reductase"
RHEA:12232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine reductase"
RHEA:12232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) = [thioredoxin]-dithiol + glycine + H(+) + phosphate
RHEA:17692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + glycochenodeoxycholate <=> adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)
GO:0031924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin B6 transporter activity
GO:0031924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B6 transmembrane transporter activity
REACT:R-SCE-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-HSA-389963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-tubulin:GTP:Cofactor B  +Cofactor E ->  alpha-tubulin:GTP: Cofactor E +Cofactor B (Homo sapiens)
REACT:R-SSC-191999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Sus scrofa)
RHEA:40243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH
RHEA:19513	skos:altLabel	"OTCase"
RHEA:19513	skos:altLabel	"citrulline phosphorylase"
RHEA:19513	skos:prefLabel	"ornithine carbamoyltransferase"
RHEA:19513	skos:altLabel	"ornithine transcarbamylase"
RHEA:19513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ornithine carbamoyltransferase"
RHEA:19513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate
RHEA:19513	skos:altLabel	"OTC"
RHEA:50466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH
REACT:R-DDI-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Dictyostelium discoideum)
RHEA:43802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-HSA-68954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm2-7 is phosphorylated by DDK (Homo sapiens)
REACT:R-HSA-450325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-FOS activation by phospho ERK1/2 (Homo sapiens)
RHEA:28503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + S-(hydroxymethyl)mycothiol => H(+) + NADH + S-formylmycothiol
RHEA:48831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NADP(+)
RHEA:29823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) = chloride(out)
RHEA:39954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
GO:0034002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity
GO:0034002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-limonene synthase activity
GO:0034002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-limonene synthase activity
GO:0034002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity
RHEA:25358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanal + formyl-CoA
REACT:R-PFA-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Plasmodium falciparum)
REACT:R-RNO-4568848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Rattus norvegicus)
RHEA:45022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine => L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine
RHEA:15392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP <=> 3',5'-cyclic AMP + diphosphate
REACT:R-BTA-8949580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F1Fo ATP synthase dimerizes (Bos taurus)
RHEA:12533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + methyl-coenzyme M => coenzyme M-coenzyme B heterodisulfide + methane
REACT:R-SSC-4167509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial BTD hydrolyses BCTN (Sus scrofa)
REACT:R-XTR-6814549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA transcript initiation, Integrator binding, LEC binding (Xenopus tropicalis)
GO:0004783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphite reductase (NADPH) activity
GO:0004783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite reductase (NADPH) activity
GO:0004783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:sulfite reductase flavoprotein
GO:0004783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent sulfite reductase activity
GO:0004783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-sulfite reductase activity
GO:0004783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
GO:0004783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H2S-NADP oxidoreductase activity
GO:0004783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen-sulfide:NADP+ oxidoreductase activity
REACT:R-CFA-8853774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Canis familiaris)
RHEA:14247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) => ATP + H2O
REACT:R-GGA-5623521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A (Gallus gallus)
RHEA:29223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-8 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + menaquinol-8
REACT:R-GGA-5423038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Gallus gallus)
RHEA:10487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-feruloylglycine <=> (E)-ferulate + glycine
RHEA:35025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone O-beta-D-glucopyranoside(in) => hydroquinone O-beta-D-glucopyranoside(out)
REACT:R-SSC-879907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate the receptor (Sus scrofa)
RHEA:17986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanal + H2O + NAD(+) => 4-(trimethylamino)butanoate + 2 H(+) + NADH
RHEA:22912	skos:altLabel	"valine--pyruvate aminotransferase"
RHEA:22912	skos:prefLabel	"valine--pyruvate transaminase"
RHEA:22912	skos:altLabel	"alanine--valine transaminase"
RHEA:22912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine
RHEA:22912	skos:altLabel	"transaminase C"
RHEA:22912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valine--pyruvate transaminase"
RHEA:59756	skos:prefLabel	"arginine N(omega)-methyltransferase"
RHEA:59756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginine N(omega)-methyltransferase"
RHEA:59756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine
REACT:R-DRE-74220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Danio rerio)
RHEA:50980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E1(out) = prostaglandin E1(in)
RHEA:59698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotetraonate + H(+) => D-cellotetraono-1,5-lactone + H2O
REACT:R-DRE-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Danio rerio)
REACT:R-BTA-5357776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)
RHEA:47318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA
GO:0001653	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endogenous peptide receptor activity
GO:0001653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide receptor activity
GO:0001653	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	exogenous peptide receptor activity
RHEA:21548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] = acetate + L-lysyl-[alpha-tubulin]
REACT:R-HSA-4085992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DAXX with SUMO1 (Homo sapiens)
RHEA:33162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)
RHEA:23715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pregnan-21-ol <=> H(+) + NADPH + pregnan-21-al
RHEA:49931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5688834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds VCP (Homo sapiens)
RHEA:21917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O => an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)
REACT:R-GGA-8863804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Gallus gallus)
RHEA:39237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-triacontenoyl-CoA + H2O => (3R)-hydroxytriacontanoyl-CoA
REACT:R-HSA-5218645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 binds p-Y397-PTK2 (Homo sapiens)
REACT:R-CFA-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
RHEA:24227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) <=> 4-methylcatechol + CO2 + NADPH
RHEA:26172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol
RHEA:26172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycothiol synthase"
RHEA:26172	skos:prefLabel	"mycothiol synthase"
REACT:R-CFA-8873929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates STARD10 (Canis familiaris)
REACT:R-HSA-8954262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Homo sapiens)
REACT:R-MMU-9609743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Mus musculus)
REACT:R-HSA-9021600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-proteins dissociate from plasma-membrane estrogen receptors (Homo sapiens)
REACT:R-XTR-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Xenopus tropicalis)
REACT:R-HSA-507719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62:MEKK3 binds to TRAF6 (Homo sapiens)
RHEA:46339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-4,17-dien-22-oyl-CoA + H2O <=> 17-hydroxy-3-oxochol-4-en-22-oyl-CoA
RHEA:20990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + 2 H(+) + 2 phosphate => ATP + 2 H2O
RHEA:39088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanedioyl-CoA + O2 => (2E)-decenedioyl-CoA + H2O2
REACT:R-BTA-6810474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Bos taurus)
RHEA:50355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH <=> 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]
RHEA:61045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:20903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-benzyloxycarbonylglycine <=> benzyl alcohol + CO2 + glycine
REACT:R-RNO-170835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Rattus norvegicus)
REACT:R-SSC-6809810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Sus scrofa)
REACT:R-DME-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Drosophila melanogaster)
REACT:R-BTA-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Bos taurus)
REACT:R-RNO-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)
RHEA:14584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 monodehydro-L-ascorbate radical + NADH <=> 2 L-ascorbate + NAD(+)
REACT:R-GGA-265987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BRCA1 (Gallus gallus)
REACT:R-XTR-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Xenopus tropicalis)
REACT:R-BTA-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Bos taurus)
REACT:R-XTR-8948234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB:4-Hyp collagen propeptides dissociates (Xenopus tropicalis)
RHEA:48620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
REACT:R-MMU-140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS1 (Mus musculus)
REACT:R-BTA-9026967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 inhibitors binds VKORC1 dimer (Bos taurus)
REACT:R-BTA-205289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of KIT (Bos taurus)
REACT:R-BTA-2029467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by CRKII:DOCK180:ELMO (Bos taurus)
REACT:R-RNO-194678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 demethylates LNSOL (Rattus norvegicus)
REACT:R-SSC-8950210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 dissociates from Interleukin-27 receptor (Sus scrofa)
REACT:R-DME-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Drosophila melanogaster)
RHEA:56588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monosubstituted aliphatic (S)-hydroxynitrile = an aldehyde + hydrogen cyanide
REACT:R-BTA-2855054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-2 binds to molecular patterns on the target cell surface  (Bos taurus)
RHEA:12623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-alanine => H(+) + L-aspartate
REACT:R-HSA-8849881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM2 associate with AMPA and NMDA receptors (Homo sapiens)
REACT:R-CFA-392054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Canis familiaris)
REACT:R-HSA-1169192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B dephosphorylates GHR (Homo sapiens)
REACT:R-XTR-6800198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Xenopus tropicalis)
RHEA:60712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic alcohol + NAD(+) = (+)-artemisinic aldehyde + H(+) + NADH
REACT:R-XTR-77587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Replication Dependent Histone mRNA with the NPC (Xenopus tropicalis)
RHEA:15447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 NH4(+) + pyruvate => H(+) + H2O + O-carbamoyl-L-serine
REACT:R-BTA-4641129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is ubiquitinated by SMURF2 (Bos taurus)
REACT:R-DME-199910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates ATF1 (Drosophila melanogaster)
REACT:R-HSA-1989747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FHL2 (Homo sapiens)
REACT:R-CFA-5339535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTPD1 transports C1P from plasma membrane to Golgi membrane (Canis familiaris)
REACT:R-MMU-5633460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds TP53 (Mus musculus)
RHEA:70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine
EC:3.4.11.18	skos:altLabel	"methionine aminopeptidase"
EC:3.4.11.18	skos:prefLabel	"methionyl aminopeptidase"
EC:3.4.11.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionyl aminopeptidase"
EC:3.4.11.18	skos:altLabel	"peptidase M"
RHEA:35109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+) => 3-nitrotyramine + H2O + O2
REACT:R-RNO-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Rattus norvegicus)
REACT:R-HSA-1791138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TPP1 (Homo sapiens)
REACT:R-BTA-2160935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 ubiquitinates RHOA (Bos taurus)
RHEA:46603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[HPr protein]-L-serine + ATP <=> [HPr protein]-O-phospho-L-serine + ADP + H(+)
RHEA:39374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)
RHEA:44396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:56092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:19154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose => 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP
REACT:R-HSA-9656891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1SW binds 11cRAL (Homo sapiens)
RHEA:51091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:26450	skos:prefLabel	"succinate-semialdehyde dehydrogenase (acetylating)"
RHEA:26450	skos:altLabel	"coenzyme-A-dependent succinate-semialdehyde dehydrogenase"
RHEA:26450	skos:altLabel	"succinyl-CoA reductase"
RHEA:26450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NADP(+) + succinate semialdehyde = H(+) + NADPH + succinyl-CoA
RHEA:26450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinate-semialdehyde dehydrogenase (acetylating)"
REACT:R-HSA-8866941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MID1IP1 binds THRSP (Homo sapiens)
REACT:R-GGA-8953461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Gallus gallus)
RHEA:69811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-109863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK3:MAP2K1 (Bos taurus)
REACT:R-MMU-6786155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLN binds ICL-DNA (Mus musculus)
REACT:R-BTA-446648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Bos taurus)
REACT:R-XTR-111253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Xenopus tropicalis)
REACT:R-HSA-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Homo sapiens)
REACT:R-BTA-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Bos taurus)
REACT:R-HSA-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Homo sapiens)
RHEA:30897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal + H2O2 + NH4(+) => H2O + O2 + propane-1,3-diamine
REACT:R-BTA-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Bos taurus)
REACT:R-HSA-9629373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to spiroiminodihydantoin in telomeric DNA (Homo sapiens)
RHEA:29540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:40466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)
RHEA:23623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(2)-(2-carboxyethyl)-L-arginine <=> AMP + deoxyamidinoproclavaminate + diphosphate + H(+)
REACT:R-DRE-8849082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 stimulates RHOA GTPase activity (Danio rerio)
REACT:R-SSC-5693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYM reduces P2C to PPCA (Sus scrofa)
REACT:R-MMU-3249378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING recruits TBK1 and STAT6 (Mus musculus)
RHEA:23436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate
REACT:R-CFA-622420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Canis familiaris)
RHEA:56496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-8951951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds EP300 (Caenorhabditis elegans)
RHEA:71136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-histidine(out) + Na(+)(out) => H(+)(out) + L-histidine(in) + Na(+)(in)
REACT:R-RNO-9656891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1SW binds 11cRAL (Rattus norvegicus)
RHEA:16709	skos:altLabel	"tryptophan hydroxylase"
RHEA:16709	skos:altLabel	"L-tryptophan hydroxylase"
RHEA:16709	skos:prefLabel	"tryptophan 5-monooxygenase"
RHEA:16709	skos:altLabel	"indoleacetic acid-5-hydroxylase"
RHEA:16709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan 5-monooxygenase"
RHEA:16709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan
RHEA:16709	skos:altLabel	"tryptophan 5-hydroxylase"
RHEA:48160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:61888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diosgenin + UDP-alpha-D-glucose = diosgenin 3-O-beta-D-glucoside + H(+) + UDP
REACT:R-BTA-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Bos taurus)
REACT:R-DRE-2730886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC by SYK kinase (Danio rerio)
REACT:R-DDI-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)
REACT:R-XTR-2029465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Xenopus tropicalis)
REACT:R-GGA-4084978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Gallus gallus)
REACT:R-CEL-1638845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERK phosphorylates CERA to form C1P (Caenorhabditis elegans)
REACT:R-BTA-8981622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin:oxygen dissociates (Bos taurus)
RHEA:63508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + O2 = a (2R)-2-hydroperoxy fatty acid
RHEA:15312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]
REACT:R-RNO-374669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds NRP1 (Rattus norvegicus)
RHEA:66807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate
RHEA:32035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase"
RHEA:32035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)
RHEA:32035	skos:prefLabel	"4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase"
RHEA:27732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli)
RHEA:17699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine => pyridine + thiamine
GO:0046964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity
GO:0046964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPS transporter activity
GO:0046964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Homo sapiens)
GO:0046964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity
GO:0046964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenosine 5'-phosphosulphate transporter activity
RHEA:24199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)
RHEA:51305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-CEL-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Caenorhabditis elegans)
GO:0004556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-D-glucan glucanohydrolase activity
GO:0004556	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-amylase activity (releasing maltohexaose)
GO:0004556	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycogenase activity
GO:0004556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha amylase activity
GO:0004556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taka-amylase A
GO:0004556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoamylase activity
GO:0004556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-amylase activity
GO:0004556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Homo sapiens)
GO:0018110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone arginine kinase activity
GO:0018110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine kinase activity
REACT:R-CFA-8848993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated KHDRBS1 translocates to the cytosol (Canis familiaris)
RHEA:36024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:66374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + phosphate => H2O + sn-glycerol 3-phosphate
REACT:R-HSA-983138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC heterotrimer to ER exit site (Homo sapiens)
REACT:R-XTR-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Xenopus tropicalis)
GO:0060090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular adaptor activity
GO:0060090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	binding, bridging
GO:0060090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein complex scaffold activity
GO:0060090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-containing complex scaffold activity
RHEA:38454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + NADP(+) + n sulfur <=> NADPH + (n+1) sulfur
RHEA:33147	skos:altLabel	"MDR protein"
RHEA:33147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type xenobiotic transporter"
RHEA:33147	skos:altLabel	"steroid-transporting ATPase"
RHEA:33147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate
RHEA:33147	skos:altLabel	"PDR protein"
RHEA:33147	skos:altLabel	"P-glycoprotein"
RHEA:33147	skos:prefLabel	"ABC-type xenobiotic transporter"
RHEA:33147	skos:altLabel	"pleiotropic-drug-resistance protein"
RHEA:33147	skos:altLabel	"xenobiotic-transporting ATPase"
RHEA:33147	skos:altLabel	"ATP phosphohydrolase (steroid-exporting)"
RHEA:33147	skos:altLabel	"multidrug-resistance protein"
RHEA:18149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate
REACT:R-GGA-201821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Gallus gallus)
RHEA:43791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O <=> ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate
REACT:R-SPO-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Schizosaccharomyces pombe)
GO:0015605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organophosphate ester transmembrane transporter activity
RHEA:25589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate + NADP(+) => (S)-oxalosuccinate + H(+) + NADPH
REACT:R-RNO-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Rattus norvegicus)
REACT:R-MMU-379048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
RHEA:29369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + phosphate => CMP + H2O
REACT:R-MMU-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)
RHEA:70740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Rattus norvegicus)
RHEA:19311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O
REACT:R-HSA-8934742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRMT1 (Homo sapiens)
REACT:R-DRE-192137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
RHEA:33472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol
REACT:R-SSC-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Sus scrofa)
RHEA:27288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetyl + H(+) + NADH => (S)-acetoin + NAD(+)
RHEA:18275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + H2O2 + NH4(+) => H2O + O2 + putrescine
RHEA:10647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-2H-pyran-4,6-dicarboxylate + H2O <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)
REACT:R-HSA-6786621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT10A methylates guanosine-9 in tRNA (Homo sapiens)
REACT:R-GGA-4084982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Gallus gallus)
REACT:R-CFA-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Canis familiaris)
RHEA:48802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose
RHEA:47989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-galactonate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH
REACT:R-PFA-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Plasmodium falciparum)
REACT:R-RNO-2197646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1 (SR-BI, CLA-1) binds ligands (Rattus norvegicus)
RHEA:15867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxytryptamine + A + H2O => AH2 + O2 + tryptamine
RHEA:33216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 3 diphosphate
REACT:R-CFA-158750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Canis familiaris)
REACT:R-HSA-5610760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
RHEA:35912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
REACT:R-HSA-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
RHEA:52810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine => adenosine in U6 snRNA + S-adenosyl-L-methionine
RHEA:52084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + H(+) + octadecanoate
REACT:R-RNO-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Rattus norvegicus)
RHEA:61955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate
RHEA:19971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + nitrite => hydroxylamine + O2
GO:0034910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-3-succinoylpyridine hydrolase activity
RHEA:31848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => shionone
RHEA:22704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ricinine nitrilase"
RHEA:22704	skos:prefLabel	"ricinine nitrilase"
RHEA:22704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + ricinine = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)
RHEA:31089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanoyl-CoA + CoA => acetyl-CoA + octanoyl-CoA
REACT:R-CFA-141202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates TYR (Canis familiaris)
RHEA:53128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-carotene = epsilon-carotene
REACT:R-MMU-9008822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1D dephosphorylates RUNX2 (Mus musculus)
REACT:R-RNO-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Rattus norvegicus)
REACT:R-RNO-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Rattus norvegicus)
GO:0050050	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine acetyltransferase activity
GO:0050050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucine N-acetyltransferase activity
GO:0050050	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:L-leucine N-acetyltransferase activity
RHEA:48175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 + H2O <=> N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate
REACT:R-SSC-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Sus scrofa)
REACT:R-HSA-71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Homo sapiens)
REACT:R-SSC-6786096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Sus scrofa)
GO:0000823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,4,5-trisphosphate 6-kinase activity
GO:0000823	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol trisphosphate 6-kinase activity
GO:0000823	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	IpmK
GO:0000823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity
GO:0000823	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol polyphosphate multikinase activity
RHEA:67657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + NADPH => 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)
REACT:R-DME-198813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO dimers reduce DeHA to AscH- (Drosophila melanogaster)
RHEA:21145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-GGA-4085133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUM (lumican) binds integrin alpha2beta1 (Gallus gallus)
GO:0106414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA dihydrouridine synthase activity
REACT:R-GGA-9757688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDN (Gallus gallus)
REACT:R-CEL-194187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:61301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-ribulose 1-phosphate => acetaldehyde + dihydroxyacetone phosphate
REACT:R-BTA-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Bos taurus)
RHEA:60318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine
REACT:R-SSC-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Sus scrofa)
REACT:R-HSA-9025033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTF3 binds NTRK2 (TRKB) (Homo sapiens)
REACT:R-BTA-9020277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Bos taurus)
REACT:R-XTR-110376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Xenopus tropicalis)
REACT:R-HSA-8848758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates AKT1 (Homo sapiens)
REACT:R-XTR-9012542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Xenopus tropicalis)
RHEA:30450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine
RHEA:69483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP
RHEA:70344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + L-tyrosine + NADP(+) => 3-chloro-L-tyrosine + NADPH
REACT:R-HSA-964759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alternative endo-mannosidase I route (Homo sapiens)
REACT:R-RNO-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Rattus norvegicus)
RHEA:71683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + L-aspartyl-glycine(out) = 2 H(+)(in) + L-aspartyl-glycine(in)
REACT:R-CFA-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Canis familiaris)
REACT:R-HSA-8849857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates CELA2 (Homo sapiens)
REACT:R-SSC-109278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Sus scrofa)
REACT:R-PFA-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Plasmodium falciparum)
RHEA:24117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => (S)-linalool + diphosphate
REACT:R-BTA-9013004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the ER membrane (Bos taurus)
RHEA:35432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => cyanidin 3,7-di-O-beta-D-glucoside + vanillate
RHEA:64365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin G2 => (15S)-15-hydroperoxy-prostaglandin E2
REACT:R-DDI-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Dictyostelium discoideum)
REACT:R-RNO-352174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Rattus norvegicus)
RHEA:21731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + H2O + 2 NAD(+) <=> GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH
GO:0015554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tartrate transmembrane transporter activity
REACT:R-HSA-992696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p53, SIN3A and MYB form a complex (Homo sapiens)
REACT:R-CEL-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-SSC-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Sus scrofa)
RHEA:39907	skos:prefLabel	"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase"
RHEA:39907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase"
RHEA:39907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate
RHEA:39313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH
REACT:R-SSC-399712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Sus scrofa)
REACT:R-RNO-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)
RHEA:72862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-c-tri-AMP + H2O <=> A[3'-5']pA[3'-5']pAp[3'] + H(+)
REACT:R-GGA-8956568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the core TAL1 complex (Gallus gallus)
RHEA:24234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-D-gluconate + NAD(+)
REACT:R-DRE-444773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-TM7 receptors bind chondroitin sulphate (Danio rerio)
REACT:R-HSA-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Homo sapiens)
RHEA:39403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)
RHEA:67408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol
REACT:R-RNO-420265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind IAPP(34-70) (Rattus norvegicus)
REACT:R-HSA-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Homo sapiens)
REACT:R-CEL-8849878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSD-95 binds NMDA receptor (Caenorhabditis elegans)
REACT:R-GGA-9624120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK2 (Gallus gallus)
REACT:R-GGA-5682826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM11 (Gallus gallus)
EC:2.1.1.332	skos:prefLabel	"bacteriochlorophyllide d C-8(2)-methyltransferase"
EC:2.1.1.332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacteriochlorophyllide d C-8(2)-methyltransferase"
REACT:R-CFA-5626962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB2L1 binds IKKA:IKKB:NEMO (Canis familiaris)
RHEA:31545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside) => all-trans-zeaxanthin + 2 UDP-alpha-D-glucose
RHEA:42539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(65) in tRNA <=> pseudouridine(65) in tRNA
REACT:R-BTA-73758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Bos taurus)
RHEA:56268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
REACT:R-BTA-5610758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Bos taurus)
REACT:R-HSA-209766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D translocates from lysosomal lumen to cytosol (Homo sapiens)
RHEA:16337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonoid 3'-monooxygenase"
RHEA:16337	skos:altLabel	"CYP75B1"
RHEA:16337	skos:altLabel	"flavonoid 3'-hydroxylase"
RHEA:16337	skos:prefLabel	"flavonoid 3'-monooxygenase"
RHEA:16337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Danio rerio)
REACT:R-SSC-392187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated P2Y purinoceptor 12 binds G-protein Gi (Sus scrofa)
RHEA:65938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose => beta-D-mannose
REACT:R-BTA-372505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylcholine synaptic vesicle docking and priming (Bos taurus)
REACT:R-HSA-177692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of recruited TAK1 within the activated TLR3 complex  (Homo sapiens)
RHEA:23275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-alkylaminopurine + UDP-alpha-D-glucose <=> an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP
REACT:R-CEL-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Caenorhabditis elegans)
RHEA:16210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-8X => cob(II)yrinate
GO:0001691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudophosphatase activity
REACT:R-XTR-2029451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Xenopus tropicalis)
REACT:R-GGA-9701000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1:BARD1 heterodimer autoubiquitinates (Gallus gallus)
RHEA:43647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-[ACP] + CO2 + CoA
REACT:R-MMU-437230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-FGFR cis-heterodimerization (Mus musculus)
RHEA:46112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Homo sapiens)
REACT:R-DRE-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Danio rerio)
RHEA:53368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(17) in tRNA + NADP(+) = H(+) + NADPH + uridine(17) in tRNA
REACT:R-MMU-9033949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Mus musculus)
REACT:R-XTR-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Xenopus tropicalis)
REACT:R-DME-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Drosophila melanogaster)
RHEA:53939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:20850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + CO2 + H2O2 => H(+) + O2 + phosphate + pyruvate
REACT:R-SSC-68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated geminin is degraded by the proteasome (Sus scrofa)
REACT:R-BTA-8848023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds STAP2 (Bos taurus)
RHEA:56404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)
REACT:R-CEL-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Caenorhabditis elegans)
REACT:R-SPO-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Schizosaccharomyces pombe)
RHEA:53046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine
RHEA:65655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine
REACT:R-CEL-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Caenorhabditis elegans)
RHEA:28455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-fructosyl)-L-lysine(in) => N(6)-(D-fructosyl)-L-lysine(out)
REACT:R-DRE-9634846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNTL (BMAL1) (Danio rerio)
REACT:R-SSC-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Sus scrofa)
REACT:R-RNO-6809263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)
RHEA:36718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + tetracosenoyl-CoA <=> an N-tetracosenoylsphinganine + CoA + H(+)
REACT:R-XTR-4420143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SH2D2A (Xenopus tropicalis)
RHEA:39132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA
REACT:R-DME-8954468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Drosophila melanogaster)
RHEA:24256	skos:prefLabel	"kanamycin kinase"
RHEA:24256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kanamycin kinase"
RHEA:24256	skos:altLabel	"APH(3')"
RHEA:24256	skos:altLabel	"neomycin-kanamycin phosphotransferase"
RHEA:24256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + kanamycin A = ADP + H(+) + kanamycin 3'-phosphate
RHEA:24256	skos:altLabel	"aminoglycoside 3'-phosphotransferase"
REACT:R-HSA-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Homo sapiens)
REACT:R-CFA-9012000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Canis familiaris)
REACT:R-SSC-193491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Sus scrofa)
RHEA:47577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) => CMP + ganglioside GD1c (d18:1(4E)) + H(+)
RHEA:34756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine => D-glucose + N-acyl-15-methylhexadecasphing-4-enine
REACT:R-BTA-5676596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds BAFFR:BAFF (Bos taurus)
REACT:R-DRE-204008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC31:SEC13 and v-SNARE recruitment (Danio rerio)
RHEA:36969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA
REACT:R-GGA-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Gallus gallus)
REACT:R-SSC-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Sus scrofa)
RHEA:28802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-prolinylglycine <=> glycine + L-proline
RHEA:63638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty acyl-[ACP] + AMP + H(+) => a medium-chain fatty acyl-AMP + holo-[ACP]
REACT:R-DRE-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Danio rerio)
REACT:R-SSC-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Sus scrofa)
REACT:R-HSA-9669893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type I TKIs (Homo sapiens)
GO:0046564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate decarboxylase activity
GO:0046564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxalate decarboxylase"
GO:0046564	skos:altLabel	"oxalate carboxy-lyase"
GO:0046564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalate carboxy-lyase (formate-forming)
GO:0046564	skos:prefLabel	"oxalate decarboxylase"
GO:0046564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxalate = CO2 + formate
GO:0046564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalate carboxy-lyase activity
RHEA:15939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H(+) + NADPH => a primary alcohol + NADP(+)
REACT:R-DRE-6803892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds BAX (Danio rerio)
REACT:R-XTR-75872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Xenopus tropicalis)
RHEA:22904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Mus musculus)
REACT:R-GGA-9756177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse ATVL to ATV (Gallus gallus)
RHEA:12752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate + H(+) <=> 1,2,3-trihydroxybenzene + CO2
REACT:R-SCE-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Saccharomyces cerevisiae)
GO:0043023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosomal large subunit binding
RHEA:44789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-11 + S-adenosyl-L-methionine => H(+) + menaquinol-11 + S-adenosyl-L-homocysteine
RHEA:40512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfopropanediol + NAD(+) => (2S)-3-sulfolactaldehyde + H(+) + NADH
RHEA:29829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg(2+)(out) => Mg(2+)(in)
REACT:R-SSC-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Sus scrofa)
REACT:R-DDI-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Dictyostelium discoideum)
REACT:R-MMU-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Mus musculus)
REACT:R-XTR-1028821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Phospho IRF3 or phospho IRF7 (Xenopus tropicalis)
RHEA:27640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate + xanthine => phosphate + xanthosine
RHEA:72878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A7 + malonyl-CoA <=> anthocyanin A9 + CoA
REACT:R-XTR-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Xenopus tropicalis)
RHEA:50285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate
REACT:R-RNO-5362551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Rattus norvegicus)
REACT:R-DRE-2730899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BCL10 and MALT1 (Danio rerio)
RHEA:70575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic UMP + H2O = H(+) + UMP
RHEA:29908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-(1'-rac-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate
RHEA:45834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanoyl-CoA + H(+) + NADH => (3R)-3-hydroxydecanoyl-CoA + NAD(+)
RHEA:38453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + (n+1) sulfur => hydrogen sulfide + NADP(+) + n sulfur
REACT:R-DME-198611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates IKKalpha (Drosophila melanogaster)
RHEA:55464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55464	skos:altLabel	"CYP76AK1"
RHEA:55464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"11-hydroxysugiol 20-monooxygenase"
RHEA:55464	skos:prefLabel	"11-hydroxysugiol 20-monooxygenase"
RHEA:55464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5685607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sialic acid binds SIGLEC (Danio rerio)
RHEA:69371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) <=> 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH
REACT:R-PFA-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Plasmodium falciparum)
REACT:R-BTA-71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Bos taurus)
RHEA:22473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantetheine + ATP => (R)-4'-phosphopantetheine + ADP + H(+)
GO:0047300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamineu-pyruvic transaminase activity
GO:0047300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine:pyruvate aminotransferase activity
GO:0047300	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyridoxamine-pyruvic transaminase
GO:0047300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine--pyruvate aminotransferase activity
GO:0047300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine-pyruvate aminotransferase activity
GO:0047300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine-pyruvate transaminase activity
RHEA:10253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + O-phospho-L-serine => L-cysteine + phosphate
REACT:R-MMU-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Mus musculus)
RHEA:56513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate
RHEA:26264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopimara-7,15-dienal + NADP(+) <=> 2 H(+) + isopimarate + NADPH
REACT:R-MMU-5423664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 hydroxylates AFB1 to AFQ1 (Mus musculus)
RHEA:70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(out) => D-alanine(in)
REACT:R-BTA-9759206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)
REACT:R-GGA-8852522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 dimer:MST1R dimer binds MST1R dimer (Gallus gallus)
REACT:R-RNO-177922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR dimerization (Rattus norvegicus)
REACT:R-CFA-2467794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of sister chromatids (Canis familiaris)
RHEA:36504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA
RHEA:28451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-psicosyl)-L-lysine(in) => N(6)-(D-psicosyl)-L-lysine(out)
RHEA:51488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaetidylserine + H(+) = archaetidylethanolamine + CO2
GO:0042012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-16R
GO:0042012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-16 receptor activity
GO:0042012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-16 receptor activity
REACT:R-HSA-70920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Homo sapiens)
REACT:R-HSA-9674550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)
REACT:R-BTA-8943780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 recruits NuRD to PTEN gene (Bos taurus)
REACT:R-DME-9654533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B recycles to the plasma membrane (Drosophila melanogaster)
REACT:R-RNO-5654625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds SHC1 (Rattus norvegicus)
RHEA:34029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+)
REACT:R-DRE-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Danio rerio)
REACT:R-BTA-3209159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERF translocates to the cytosol (Bos taurus)
RHEA:63179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ibuprofenoyl-CoA <=> (2R)-ibuprofenoyl-CoA
RHEA:57467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + UDP-alpha-D-glucose <=> 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP
REACT:R-HSA-2473186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FSTL3 binds Activin (Homo sapiens)
REACT:R-HSA-751039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (12/13) reassociates with G beta:gamma (Homo sapiens)
REACT:R-RNO-4085994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates SIN3A with SUMO1 (Rattus norvegicus)
RHEA:54974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP]
GO:0033953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-agarase activity
GO:0033953	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	agarase activity
GO:0033953	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	agarase A33 activity
GO:0033953	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	agarose 3-glycanohydrolase activity
RHEA:55065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanoyl-CoA + H2O => 4-methylpentanoate + CoA + H(+)
RHEA:35108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitrotyramine + H2O + O2 => 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)
REACT:R-MMU-8865182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7A hydrolyses K11diUb (Mus musculus)
REACT:R-SSC-5661115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Sus scrofa)
RHEA:62018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose
REACT:R-HSA-5638137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFRvIII cancer variant does not bind EGF ligand (Homo sapiens)
REACT:R-BTA-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Bos taurus)
REACT:R-MMU-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Mus musculus)
REACT:R-SSC-5357757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC(cIAP1/2) ubiquitinates RIPK1 (Sus scrofa)
GO:0008664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-5'-RNA ligase activity
GO:0008664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-5' RNA ligase activity
RHEA:63864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octadecanoate = (2R)-2-hydroperoxyoctadecanoate
REACT:R-SSC-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Sus scrofa)
REACT:R-BTA-5218839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Bos taurus)
REACT:R-HSA-3928640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs phosphorylate MLC (Homo sapiens)
REACT:R-DME-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
RHEA:51538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP => L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:38896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)
RHEA:36681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH => dTDP-6-deoxy-alpha-D-allose + NAD(+)
RHEA:69523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-galactosamino-1,5-lactone <=> H(+) + N-acetyl-D-galactosaminate
REACT:R-CFA-9605644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Canis familiaris)
RHEA:45552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine
REACT:R-CFA-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-CEL-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Caenorhabditis elegans)
REACT:R-CFA-9714959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to TNF(1-233) trimer (Canis familiaris)
RHEA:30060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + fumarate => orotate + succinate
REACT:R-HSA-72143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lariat Formation and 5'-Splice Site Cleavage (Homo sapiens)
RHEA:64677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoyl-CoA + butan-1-ol => butyl 3-(methylsulfanyl)propanoate + CoA
GO:0042007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-18 binding
GO:0042007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-18 binding
RHEA:48706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpEPE => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2
REACT:R-DRE-140840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Danio rerio)
RHEA:20431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acacetin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine
RHEA:22836	skos:altLabel	"fatty acid condensing enzyme"
RHEA:22836	skos:altLabel	"3-ketoacyl-acyl carrier protein synthase"
RHEA:22836	skos:altLabel	"beta-ketoacyl-ACP synthase I"
RHEA:22836	skos:altLabel	"condensing enzyme"
RHEA:22836	skos:altLabel	"beta-ketoacyl-[acyl carrier protein] synthase"
RHEA:22836	skos:altLabel	"acyl-malonyl acyl carrier protein-condensing enzyme"
RHEA:22836	skos:altLabel	"3-oxoacyl-[acyl-carrier-protein] synthase"
RHEA:22836	skos:altLabel	"beta-ketoacyl acyl carrier protein synthase"
RHEA:22836	skos:altLabel	"beta-ketoacyl-acyl carrier protein synthetase"
RHEA:22836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]
RHEA:22836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-ketoacyl-[acyl-carrier-protein] synthase I"
RHEA:22836	skos:altLabel	"beta-ketoacyl-ACP synthetase"
RHEA:22836	skos:altLabel	"beta-ketoacyl synthetase"
RHEA:22836	skos:altLabel	"acyl-malonyl(acyl-carrier-protein)-condensing enzyme"
RHEA:22836	skos:altLabel	"KAS I"
RHEA:22836	skos:altLabel	"beta-ketoacylsynthase"
RHEA:22836	skos:prefLabel	"beta-ketoacyl-[acyl-carrier-protein] synthase I"
REACT:R-CFA-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Canis familiaris)
REACT:R-DRE-8950181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y693-STAT4 dimer translocates to the nucleus (Danio rerio)
REACT:R-MMU-1676164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Mus musculus)
REACT:R-MMU-352052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Mus musculus)
REACT:R-RNO-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:17838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-D-arabinitol 1-phosphate + H2O => 2-carboxy-D-arabinitol + phosphate
REACT:R-MMU-6810410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Mus musculus)
REACT:R-CFA-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Canis familiaris)
RHEA:50228	skos:prefLabel	"resorcinol 4-hydroxylase (FADH2)"
RHEA:50228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"resorcinol 4-hydroxylase (FADH2)"
RHEA:50228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 + resorcinol = benzene-1,2,4-triol + FAD + H(+) + H2O
REACT:R-XTR-1222685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathelicidin LL-37 binds to bacterial cell wall (Xenopus tropicalis)
RHEA:59575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-homocarnosine <=> 4-aminobutanoate + L-histidine
REACT:R-RNO-210300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and TREM2 (Rattus norvegicus)
REACT:R-MMU-9024993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Mus musculus)
RHEA:40673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + pyruvate => 2-iminopropanoate + H2O
REACT:R-GGA-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Gallus gallus)
EC:2.8.2.11	skos:prefLabel	"galactosylceramide sulfotransferase"
EC:2.8.2.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactosylceramide sulfotransferase"
RHEA:56442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-RNO-879562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Rattus norvegicus)
RHEA:34594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-7 + S-adenosyl-L-methionine <=> Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Drosophila melanogaster)
GO:0018624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toluene dioxygenase activity
GO:0018624	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
GO:0018624	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	toluene 2,3-dioxygenase activity
GO:0018624	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	toluene 1,2-dioxygenase activity
RHEA:67861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] => 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)
RHEA:26492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ketone + H(+) + H2O2 + nitrite => a secondary nitroalkane + H2O + O2
REACT:R-HSA-8935930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-18a binds RUNX1 mRNA (Homo sapiens)
RHEA:12532	skos:prefLabel	"coenzyme-B sulfoethylthiotransferase"
RHEA:12532	skos:altLabel	"methyl-CoM reductase"
RHEA:12532	skos:altLabel	"methyl coenzyme M reductase"
RHEA:12532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane
RHEA:12532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coenzyme-B sulfoethylthiotransferase"
RHEA:57306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + GMP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP
GO:0098631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein binding involved in cell adhesion
GO:0098631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesion mediator activity
GO:0098631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesion molecule
RHEA:32271	skos:altLabel	"IMDH"
RHEA:32271	skos:altLabel	"beta-isopropylmalate dehydrogenase"
RHEA:32271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-isopropylmalate dehydrogenase"
RHEA:32271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH
RHEA:32271	skos:altLabel	"beta-IPM dehydrogenase"
RHEA:32271	skos:prefLabel	"3-isopropylmalate dehydrogenase"
REACT:R-BTA-159836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)
REACT:R-CFA-9727198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B exchanges K+ for H+ (Canis familiaris)
REACT:R-MMU-159752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Mus musculus)
REACT:R-DRE-2872497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-2 transports cytosolic urate to extracellular region (Danio rerio)
REACT:R-DDI-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Dictyostelium discoideum)
REACT:R-XTR-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Xenopus tropicalis)
RHEA:60843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]
REACT:R-DME-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-RNO-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Rattus norvegicus)
REACT:R-XTR-174132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Cyclin B:Cdc2 (Xenopus tropicalis)
REACT:R-RNO-8987033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Rattus norvegicus)
RHEA:45490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit]
REACT:R-DME-1912357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH ubiquitinates DTX (Drosophila melanogaster)
RHEA:10695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 <=> H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone
REACT:R-CFA-3878123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of SAHF formation (Canis familiaris)
REACT:R-DDI-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Dictyostelium discoideum)
REACT:R-DRE-3296326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR1 binds LACT (Danio rerio)
REACT:R-DRE-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Danio rerio)
RHEA:61826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pregnenolone 3-beta-D-glucoside + UDP => pregnenolone + UDP-alpha-D-glucose
REACT:R-BTA-3788745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL8 promoter (Bos taurus)
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol carrier protein
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peroxisome sterol carrier protein thiolase
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxopristanoyl-CoA thiolase activity
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxopristanoyl-CoA hydrolase activity
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SCPx
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA C2-trimethyltridecanoyltransferase activity
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA C(2)-trimethyltridecanoyltransferase activity
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxopristanoyl-CoA thiolase activity
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol carrier protein X-related thiolase activity
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peroxisomal 3-oxoacyl coenzyme A thiolase
GO:0050632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity
REACT:R-RNO-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Rattus norvegicus)
RHEA:62482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O
RHEA:58686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + NADP(+) => FAD + 2 H(+) + NADPH + O2
REACT:R-BTA-1606564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Bos taurus)
REACT:R-CFA-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Canis familiaris)
REACT:R-CFA-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Canis familiaris)
REACT:R-DDI-5229203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates histone H2A arginine-30 (H2AR29) (Dictyostelium discoideum)
RHEA:27728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxopropanoate + pyruvate => 5-dehydro-4-deoxy-D-glucarate
RHEA:30926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)
REACT:R-CFA-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)
REACT:R-SSC-8851929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Sus scrofa)
RHEA:70566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:42152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine
RHEA:52238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + Fe(2+) + 3 H2O + mycobilin b => 3 AH2 + 2 H(+) + heme b + 3 O2
RHEA:29620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltotetraose + beta-maltose => alpha-maltopentaose + beta-D-glucose
REACT:R-XTR-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Xenopus tropicalis)
RHEA:69969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + K(+)(in) + 4 Na(+)(out) => Ca(2+)(out) + K(+)(out) + 4 Na(+)(in)
GO:0140397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	versiconal hemiacetal acetate esterase activity
RHEA:65278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone
RHEA:59616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-L-arginine + H2O = beta-alanine + L-arginine
REACT:R-MMU-9626880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Mus musculus)
REACT:R-RNO-2730903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of TRAF6 (Rattus norvegicus)
REACT:R-BTA-9688459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds HSP90:CDC37 (Bos taurus)
GO:0140890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H1 histone chaperone activity
GO:0140890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H1 histone carrier activity
REACT:R-RNO-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)
RHEA:60785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A24 + O2 => CO2 + gibberellin A25 + H(+) + succinate
RHEA:48690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl => H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine
RHEA:45332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)
RHEA:45332	skos:prefLabel	"7,8-dihydroneopterin oxygenase"
RHEA:45332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7,8-dihydroneopterin oxygenase"
RHEA:64375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O <=> alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine
REACT:R-DME-5665999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 translocates from cytosol to the nucleus (Drosophila melanogaster)
REACT:R-HSA-5603108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MAOA does not oxidatively deaminate 5HT (Homo sapiens)
RHEA:47366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic alcohol + dodecanoate + H(+) => a dodecanoate ester + H2O
REACT:R-BTA-2328037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds integrins (Bos taurus)
RHEA:15560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Ni(2+)(out) <=> ADP + H(+) + Ni(2+)(in) + phosphate
RHEA:65477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + butanoyl-CoA => CoA + propyl butanoate
RHEA:13920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH
REACT:R-GGA-5693566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 associates with H4K20Me2 at DNA DSBs (Gallus gallus)
EC:2.7.1.73	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inosine kinase"
EC:2.7.1.73	skos:altLabel	"inosine-guanosine kinase"
EC:2.7.1.73	skos:prefLabel	"inosine kinase"
EC:1.1.1.111	skos:prefLabel	"3-(imidazol-5-yl)lactate dehydrogenase"
EC:1.1.1.111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-(imidazol-5-yl)lactate dehydrogenase"
REACT:R-CFA-6785762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL13RA1 binds TYK2 (Canis familiaris)
RHEA:21479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP
RHEA:32471	skos:prefLabel	"marmesin synthase"
RHEA:32471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"marmesin synthase"
RHEA:32471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] = (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:13911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate + urate => phosphate + urate D-ribonucleoside
REACT:R-SSC-173488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
RHEA:57440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] = 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
RHEA:37921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2
REACT:R-BTA-2395876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
RHEA:17062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + phenol => catechol + H2O + NADP(+)
REACT:R-HSA-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
REACT:R-XTR-193407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
RHEA:45947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-DRE-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Danio rerio)
RHEA:29390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H2O <=> CDP + H(+) + phosphate
REACT:R-DRE-5419281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRRF binds 55S ribosome:mRNA:tRNA (Danio rerio)
REACT:R-RNO-109415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => adenosine + orthophosphate [NT5C1B] (Rattus norvegicus)
REACT:R-CFA-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Canis familiaris)
RHEA:55509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:10967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate + H(+)
REACT:R-BTA-9034042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Bos taurus)
RHEA:18469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamine N-acyltransferase"
RHEA:18469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
RHEA:18469	skos:prefLabel	"glutamine N-acyltransferase"
REACT:R-HSA-427337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBD2 binds methylcytosine in chromatin (Homo sapiens)
REACT:R-SSC-5661123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate Me2K5-histone H3 (Sus scrofa)
REACT:R-SPO-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Schizosaccharomyces pombe)
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UBP
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deubiquitylase
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitinyl hydrolase 1 activity
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deubiquitinating enzyme
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiol-dependent ubiquitin-specific protease activity
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ubiquitinyl hydrolase activity
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquitin C-terminal hydrolase
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type deubiquitinase activity
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ubiquitin hydrolase activity
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UCH2
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deubiquitinase
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deubiquitinase activity
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiol-dependent deubiquitinase
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ubiquitin-specific protease activity
GO:0004843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiol-dependent ubiquitinyl hydrolase activity
REACT:R-DME-176494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to 27HCHOL (Drosophila melanogaster)
GO:0050364	skos:altLabel	"tryptophan dimethylallyltransferase"
GO:0050364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity
GO:0050364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyltryptophan synthetase activity
GO:0050364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan dimethylallyltransferase activity
GO:0050364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(gamma,gamma-dimethylallyl)tryptophan synthase activity
GO:0050364	skos:prefLabel	"4-dimethylallyltryptophan synthase"
GO:0050364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-dimethylallyltryptophan synthase"
GO:0050364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DMAT synthetase activity
GO:0050364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate
GO:0050364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity
GO:0050364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity
RHEA:40601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O
RHEA:25332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnitine + H(+) + NADH => (R)-carnitine + NAD(+)
RHEA:54487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine
RHEA:26505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + UDP
REACT:R-RNO-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Rattus norvegicus)
REACT:R-CEL-5661121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Caenorhabditis elegans)
RHEA:46351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H2O <=> 3-hydroxyoctanoyl-CoA
REACT:R-DME-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Drosophila melanogaster)
REACT:R-DRE-3215295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates MDM2 (Danio rerio)
RHEA:65994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-trans-vitamin D3 => calciol + hnu
RHEA:63748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-2-N-beta-D-glucuronide
REACT:R-SPO-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Schizosaccharomyces pombe)
REACT:R-DME-432513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLK is phosphorylated by DCO (Drosophila melanogaster)
RHEA:10694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone => 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2
REACT:R-RNO-9614423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO1 (Rattus norvegicus)
RHEA:22013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-4 + S-adenosyl-L-methionine => precorrin-5 + S-adenosyl-L-homocysteine
RHEA:12271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + putrescine <=> 1-pyrroline + H2O + L-glutamate
REACT:R-CEL-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)
RHEA:16113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanocobalamin reductase"
RHEA:16113	skos:prefLabel	"cyanocobalamin reductase"
RHEA:16113	skos:altLabel	"cyanocobalamin reductase (NADPH, cyanide-eliminating)"
RHEA:16113	skos:altLabel	"cyanocobalamin reductase (cyanide-eliminating)"
RHEA:16113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH
RHEA:16113	skos:altLabel	"NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating)"
RHEA:16113	skos:altLabel	"cyanocobalamin reductase (NADPH; CN-eliminating)"
REACT:R-XTR-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Xenopus tropicalis)
REACT:R-DRE-158311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Danio rerio)
REACT:R-HSA-8855564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Homo sapiens)
REACT:R-XTR-3318486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Xenopus tropicalis)
REACT:R-BTA-975142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Bos taurus)
RHEA:41413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-DME-194187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-CEL-373714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-Heterodimerization of nephrin and KIRREL (Caenorhabditis elegans)
RHEA:38211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA
GO:0016262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein N-GlcNAc transferase activity
GO:0016262	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-GlcNAc transferase activity
GO:0016262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity
GO:0016262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein N-acetylglucosaminyltransferase activity
GO:0016262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity
GO:0016262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity
GO:0016262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity
RHEA:23816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate
REACT:R-DME-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)
RHEA:72605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-AMP + diphosphate => (E)-sinapate + ATP + H(+)
REACT:R-DRE-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Danio rerio)
REACT:R-XTR-194187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:20820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline sulfate + H2O = choline + H(+) + sulfate
RHEA:20820	skos:prefLabel	"choline-sulfatase"
RHEA:20820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choline-sulfatase"
RHEA:65316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chrodrimanin H + O2 = chrodrimanin E + CO2 + H2O + succinate
RHEA:46619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]
REACT:R-GGA-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Gallus gallus)
RHEA:57636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate = holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate
RHEA:45129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)
REACT:R-DME-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Drosophila melanogaster)
REACT:R-MMU-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Mus musculus)
RHEA:31986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
REACT:R-DRE-9677320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS1 dimer binds PTGS1 Inhibitors (Danio rerio)
REACT:R-CFA-5661115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Canis familiaris)
RHEA:16024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate <=> enol-oxaloacetate
RHEA:39142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA
RHEA:63978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + pyriculariol => A + dihydropyriculariol
RHEA:68961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxycoumarin + S-adenosyl-L-methionine => 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-5654701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
RHEA:68858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-beta-farnesene + diphosphate => (2Z,6E)-farnesyl diphosphate
GO:0034076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitadienol synthase activity
REACT:R-XTR-1006143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C3b (Xenopus tropicalis)
RHEA:58507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> (3Z)-2-oxo-4-carboxy-3-hexenedioate
REACT:R-DRE-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Danio rerio)
RHEA:28505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + S-(hydroxymethyl)mycothiol <=> H(+) + NADH + S-formylmycothiol
REACT:R-SSC-389026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galanin receptors can bind galanin (Sus scrofa)
REACT:R-SSC-9604480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFkB complex translocates from the cytosol to the nucleus (Sus scrofa)
REACT:R-RNO-205286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS interacts with p-KIT (Rattus norvegicus)
RHEA:49033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:48028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triacetin = acetate + diacetylglycerol + H(+)
REACT:R-RNO-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Rattus norvegicus)
RHEA:52176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-6798257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRS binds NTRK3 (Bos taurus)
REACT:R-BTA-2213246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of CLIP from MHC II (Bos taurus)
RHEA:18321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate
REACT:R-SSC-1535903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Sus scrofa)
REACT:R-BTA-8877941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SMAD1 in the nucleus (Bos taurus)
GO:0004779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate adenylyltransferase activity
GO:0004779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphate adenylyltransferase activity
RHEA:24093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 sulochrin => 2 (2S)-bisdechlorogeodin + 2 H2O
REACT:R-SSC-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Sus scrofa)
REACT:R-BTA-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
RHEA:56643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-SSC-5607753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD9 oligomerizes (Sus scrofa)
REACT:R-SSC-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Sus scrofa)
REACT:R-HSA-6801355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the NLRC4 gene (Homo sapiens)
REACT:R-HSA-378978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Homo sapiens)
REACT:R-HSA-1017228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex (Homo sapiens)
RHEA:35796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine => H(+) + kanamycin A + UDP
REACT:R-HSA-6807077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)
RHEA:52028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonyl-L-amino acid + H2O = a jasmonate + an L-alpha-amino acid
REACT:R-CFA-8938431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 and BTN1A1 binds periplakin (PPL) (Canis familiaris)
RHEA:45599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-CEL-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Caenorhabditis elegans)
RHEA:65290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine
REACT:R-RNO-1650808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Rattus norvegicus)
RHEA:58099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetracosanoylglycerol + H2O <=> glycerol + H(+) + tetracosanoate
RHEA:30262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a menaquinol + O2 <=> 2 a menaquinone + 2 H2O
REACT:R-XTR-8877153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 binds PC (Xenopus tropicalis)
RHEA:70854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) <=> H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)
RHEA:72623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base = a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base
REACT:R-SCE-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Saccharomyces cerevisiae)
REACT:R-RNO-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)
RHEA:38507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate
GO:0034618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminopentanoic acid binding
GO:0034618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arg binding
GO:0034618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine binding
REACT:R-RNO-8876615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB13 GEFs exchange GTP for GDP on RAB13 (Rattus norvegicus)
REACT:R-HSA-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Homo sapiens)
RHEA:52798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ni(2+) + sirohydrochlorin => 2 H(+) + Ni-sirohydrochlorin
REACT:R-XTR-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Xenopus tropicalis)
GO:0016783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfurtransferase activity
GO:0016783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is transferred onto sulfite (Homo sapiens)
GO:0016783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphurtransferase activity
EC:3.1.1.64	skos:altLabel	"all-trans-retinyl-palmitate hydrolase"
EC:3.1.1.64	skos:altLabel	"all-trans-retinylester 11-cis isomerohydrolase"
EC:3.1.1.64	skos:prefLabel	"retinoid isomerohydrolase"
EC:3.1.1.64	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"retinoid isomerohydrolase"
RHEA:25192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetate + H2O <=> chloride + glycolate + H(+)
REACT:R-SSC-2029465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)
GO:0008828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP diphosphatase activity
GO:0008828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP pyrophosphohydrolase activity
GO:0008828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-adenosine triphosphate pyrophosphatase activity
GO:0008828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-(d)ATP pyrophosphatase activity
GO:0008828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity
GO:0008828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-ATP pyrophosphatase activity
REACT:R-DRE-5693602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM recognizes H2AFX-Nucleosomes (Danio rerio)
REACT:R-CEL-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
REACT:R-SPO-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Schizosaccharomyces pombe)
RHEA:42525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(1911/1915/1917) in 23S rRNA => pseudouridine(1911/1915/1917) in 23S rRNA
REACT:R-MMU-8851899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Mus musculus)
GO:0015626	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cystine/diaminopimelate porter activity
GO:0015626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-diaminopimelate transmembrane transporter activity
GO:0015626	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-diaminopimelate transporter activity
RHEA:54397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
REACT:R-CEL-8963915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D binds VDR (Caenorhabditis elegans)
REACT:R-HSA-1855190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 transports from the cytosol to the nucleus (Homo sapiens)
RHEA:29104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+)(in) + menaquinone-8 + NADH => 4 H(+)(out) + menaquinol-8 + NAD(+)
RHEA:62896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)
RHEA:25934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylquinolin-2(1H)-one + AH2 => 4-methylquinoline + A + H2O
REACT:R-HSA-8950354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)
REACT:R-DME-1358801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds RNF41 ubiquitin ligase (Drosophila melanogaster)
REACT:R-MMU-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Mus musculus)
RHEA:51883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,6-trichlorocatechol + O2 <=> (2Z,4E)-2,3,5-trichloromuconate + H(+)
RHEA:57575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33983	skos:prefLabel	"miltiradiene synthase"
RHEA:33983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"miltiradiene synthase"
RHEA:33983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate = diphosphate + miltiradiene
RHEA:49582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic pyranopterin phosphate + diphosphate => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate
RHEA:37854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-deoxydaunorubicin + H(+) + NADPH + O2 <=> 13-dihydrodaunorubicin + H2O + NADP(+)
RHEA:12460	skos:altLabel	"fumarase"
RHEA:12460	skos:prefLabel	"fumarate hydratase"
RHEA:12460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate = fumarate + H2O
RHEA:12460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumarate hydratase"
REACT:R-CEL-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
RHEA:63615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin + UDP-alpha-D-glucuronate <=> prunetin-5-O-beta-D-glucuronide + UDP
REACT:R-DME-174202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Securin (Drosophila melanogaster)
RHEA:12121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + ATP + H(+) => ADP-alpha-D-glucose + diphosphate
REACT:R-XTR-9639287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2 binds L-leucine and dissociates from GATOR2 (Xenopus tropicalis)
RHEA:19446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxyindole + O2 => anthranilate + CO2 + H(+)
REACT:R-MMU-9759154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM21 ubiquitinates SQSTM1 (Mus musculus)
REACT:R-HSA-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Homo sapiens)
REACT:R-RNO-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Rattus norvegicus)
RHEA:26514	skos:prefLabel	"cyclohexane-1,2-dione hydrolase"
RHEA:26514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexane-1,2-dione hydrolase"
RHEA:26514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexan-1,2-dione + H2O = 6-oxohexanoate + H(+)
REACT:R-HSA-350604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Agmatine + H2O <=> putrescine + urea (Homo sapiens)
REACT:R-BTA-5683077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate KDM4A,B (Bos taurus)
REACT:R-SCE-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Saccharomyces cerevisiae)
REACT:R-HSA-9658445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
REACT:R-MMU-74716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin binds the insulin receptor (Mus musculus)
REACT:R-HSA-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Homo sapiens)
REACT:R-XTR-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Xenopus tropicalis)
RHEA:23605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kievitone hydrate => H2O + kievitone
RHEA:39427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)
REACT:R-BTA-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Bos taurus)
REACT:R-SSC-9035227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN2 binds CysS248-MPST (Sus scrofa)
RHEA:20000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphoenolpyruvate <=> phosphate + pyruvate
REACT:R-GGA-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Gallus gallus)
REACT:R-HSA-1299484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM8:TIMM13 chaperones hydrophobic proteins (Homo sapiens)
REACT:R-HSA-1606288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Homo sapiens)
RHEA:70422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetyl-CoA + H2O <=> 3,4-dihydroxyphenylacetate + CoA + H(+)
REACT:R-DRE-170026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protons are translocated from the intermembrane space to the matrix (Danio rerio)
REACT:R-SSC-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Sus scrofa)
REACT:R-RNO-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Rattus norvegicus)
REACT:R-DRE-432110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Danio rerio)
REACT:R-DME-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Drosophila melanogaster)
REACT:R-RNO-418091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB1 (Rattus norvegicus)
REACT:R-SSC-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Sus scrofa)
RHEA:34283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-tyrosine + O2 = 2 L-dopa
RHEA:63777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-203156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-derived TREM-1 ligand binds to TREM-1 (Canis familiaris)
REACT:R-SCE-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Saccharomyces cerevisiae)
RHEA:34869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + thiophene-2-carbonyl-CoA => ATP + CoA + thiophene-2-carboxylate
REACT:R-HSA-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
REACT:R-CFA-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Canis familiaris)
RHEA:69738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylsuccinate + succinyl-CoA <=> 2-phenylsuccinyl-CoA + succinate
REACT:R-DDI-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Dictyostelium discoideum)
REACT:R-HSA-4084501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII binds collagen type IV (Homo sapiens)
RHEA:28444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP]
REACT:R-MMU-3640874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-RibC-AXIN is degraded by the proteasome (Mus musculus)
RHEA:29084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + ubiquinone-8 => oxaloacetate + ubiquinol-8
REACT:R-HSA-3364026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
RHEA:42587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:71692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamate(out) + 2 H(+)(out) => glycyl-L-glutamate(in) + 2 H(+)(in)
REACT:R-CFA-8982640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Canis familiaris)
RHEA:33270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+) <=> 2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+)
REACT:R-SSC-2395849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
REACT:R-RNO-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Rattus norvegicus)
REACT:R-MMU-8950453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Mus musculus)
RHEA:58780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine = a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine
REACT:R-HSA-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Homo sapiens)
REACT:R-DRE-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Danio rerio)
REACT:R-SSC-176669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Sus scrofa)
REACT:R-HSA-981809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Homo sapiens)
REACT:R-GGA-8948226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Gallus gallus)
REACT:R-BTA-9755303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades HIFalpha (Bos taurus)
RHEA:53843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH
REACT:R-HSA-389352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Vav1 to CD28 (Homo sapiens)
REACT:R-HSA-3215144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription (Homo sapiens)
REACT:R-HSA-9725206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds FCERI (Homo sapiens)
REACT:R-HSA-6791218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
REACT:R-DRE-3465459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Danio rerio)
REACT:R-XTR-5683964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates EYA1-4 (Xenopus tropicalis)
RHEA:37082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:51478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O => a ribonucleoside 5'-triphosphate + formate + H(+)
REACT:R-BTA-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Bos taurus)
REACT:R-XTR-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Xenopus tropicalis)
REACT:R-GGA-8853405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 binds AURKA at centrosomes (Gallus gallus)
REACT:R-XTR-444838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 1 binds relaxin 2 and 3 (Xenopus tropicalis)
REACT:R-HSA-1250357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds P-ERBB4 isoform dimers (Homo sapiens)
RHEA:33347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminoacetate + H2O = glyoxylate + NH4(+)
GO:0102590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity
REACT:R-DRE-8848930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 translocates to the nucleus (Danio rerio)
REACT:R-SCE-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Saccharomyces cerevisiae)
REACT:R-SCE-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Saccharomyces cerevisiae)
REACT:R-RNO-5654510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 binds SPRED1/2 (Rattus norvegicus)
REACT:R-HSA-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)
REACT:R-HSA-1791107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)
REACT:R-RNO-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Rattus norvegicus)
REACT:R-RNO-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Rattus norvegicus)
RHEA:28571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine => diphosphate + L-seryl-5'-AMP
RHEA:36322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADPH + octadecanoyl-CoA <=> CoA + 2 NADP(+) + octadecan-1-ol
REACT:R-DRE-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Danio rerio)
RHEA:25661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1855179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Rattus norvegicus)
REACT:R-HSA-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Homo sapiens)
REACT:R-BTA-5669023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TWEAK binds FN14 (Bos taurus)
REACT:R-RNO-8875816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds activated MET receptor (Rattus norvegicus)
REACT:R-CEL-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:39911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-methylphenylalanine transaminase"
RHEA:39911	skos:prefLabel	"beta-methylphenylalanine transaminase"
RHEA:39911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate
RHEA:10101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sterol ester + H2O => a fatty acid + a sterol + H(+)
RHEA:16577	skos:altLabel	"diadenosinetetraphosphate alphabeta-phosphorylase"
RHEA:16577	skos:prefLabel	"ATP adenylyltransferase"
RHEA:16577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ATP adenylyltransferase"
RHEA:16577	skos:altLabel	"diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase"
RHEA:16577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate
RHEA:16577	skos:altLabel	"bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming)"
RHEA:16577	skos:altLabel	"AP-4-A phosphorylase"
REACT:R-SSC-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Sus scrofa)
REACT:R-SSC-6786070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Sus scrofa)
REACT:R-DRE-8871266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD3 (Danio rerio)
REACT:R-CFA-195408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Canis familiaris)
RHEA:12316	skos:altLabel	"inositol-1,3-bisphosphate 3-phosphatase"
RHEA:12316	skos:altLabel	"D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase"
RHEA:12316	skos:altLabel	"inositol 1,3-bisphosphate phosphatase"
RHEA:12316	skos:altLabel	"phosphatidyl-3-phosphate 3-phosphohydrolase"
RHEA:12316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol-3-phosphatase"
RHEA:12316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:12316	skos:prefLabel	"phosphatidylinositol-3-phosphatase"
RHEA:12316	skos:altLabel	"inositol-polyphosphate 3-phosphatase"
RHEA:55223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
RHEA:42692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1->4)-alpha-D-glucosyl](n+2) + phosphate
RHEA:42692	skos:prefLabel	"starch synthase (maltosyl-transferring)"
RHEA:42692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"starch synthase (maltosyl-transferring)"
RHEA:42692	skos:altLabel	"alpha1,4-glucan:maltose-1-P maltosyltransferase"
RHEA:42692	skos:altLabel	"GMPMT"
RHEA:20562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + H(+) => CO2 + glycolaldehyde
RHEA:60246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3] => 2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]
REACT:R-HSA-1222712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitrosoglutathione gets cleaved to Cys(NO)-Gly (Homo sapiens)
REACT:R-SSC-5625959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Sus scrofa)
REACT:R-GGA-378975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follitropin is a heterodimer (Gallus gallus)
REACT:R-XTR-9027633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Xenopus tropicalis)
REACT:R-HSA-187697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRKA recruits RIT and RIN (Homo sapiens)
REACT:R-SSC-74730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin degradation (Sus scrofa)
RHEA:31646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycinamicin VI + S-adenosyl-L-methionine <=> H(+) + mycinamicin III + S-adenosyl-L-homocysteine
REACT:R-BTA-2584246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT1-GTP hydrolyses its bound GTP to GDP (Bos taurus)
RHEA:64998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + octanoyl-AMP => ATP + H(+) + octanoate
RHEA:33361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-GGA-1504186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL recruits GSK3beta:AXIN1 to the receptor complex (Gallus gallus)
RHEA:51606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Homo sapiens)
RHEA:61592	skos:altLabel	"anaerobic sulfatase maturase"
RHEA:61592	skos:altLabel	"Cys-type anaerobic sulfatase-maturating enzyme"
RHEA:61592	skos:prefLabel	"cysteine-type anaerobic sulfatase-maturating enzyme"
RHEA:61592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine
RHEA:61592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine-type anaerobic sulfatase-maturating enzyme"
GO:0018556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2',3-trihydroxybiphenyl dioxygenase activity
REACT:R-CFA-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Canis familiaris)
RHEA:68127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a fatty acyl-[ACP] <=> a triacylglycerol + holo-[ACP]
REACT:R-HSA-8940001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2:CBFB binds the MMP13 gene promoter (Homo sapiens)
RHEA:59175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]
REACT:R-MMU-2230983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP1:Hemopexin:heme is endocytosed (Mus musculus)
REACT:R-BTA-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Bos taurus)
RHEA:53539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate
RHEA:39048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]
RHEA:15224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)
REACT:R-CFA-2466106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BGN binds Collagen types I, VI, (IX) (Canis familiaris)
REACT:R-BTA-5693542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RPA complexes with ssDNA at resected DNA DSBs (Bos taurus)
RHEA:41482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an episterol ester + CoA => an acyl-CoA + episterol
RHEA:68026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + presqualene alcohol => H2O + presqualene monophosphate
REACT:R-SSC-8963915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D binds VDR (Sus scrofa)
REACT:R-HSA-139895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAK protein (Homo sapiens)
RHEA:51413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate
GO:0071913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate secondary active transmembrane transporter activity
GO:0071913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate carrier activity
RHEA:61866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + probetaenone I => AH2 + dehydroprobetaenone I
RHEA:53076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine = 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:14570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propane-1,2-diol => H2O + propanal
REACT:R-RNO-2129385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFAP2, MFAP5 bind microfibrils (Rattus norvegicus)
RHEA:66037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate
REACT:R-XTR-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Xenopus tropicalis)
RHEA:51390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-dopamine => acetyl-CoA + dopamine
RHEA:30388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-glucose + phosphate => alpha-D-glucose 1-phosphate + GDP + H(+)
REACT:R-DME-8849891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-3 bind to PSD-95 family members (Drosophila melanogaster)
REACT:R-BTA-870538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Bos taurus)
RHEA:36948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA
REACT:R-BTA-9709317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to free ferrohemoglobin (Bos taurus)
RHEA:55993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
REACT:R-SSC-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Sus scrofa)
RHEA:24041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 oxidized [cytochrome P450] => H(+) + NADP(+) + 2 reduced [cytochrome P450]
REACT:R-HSA-180599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Vpu:CD4:beta-TrCP complex recruits SKP1 (Homo sapiens)
REACT:R-BTA-1011600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rabenosyn-5 connects  Rab5 to VPS-45 (Bos taurus)
RHEA:13584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP
REACT:R-CFA-9611721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1-agonists bind ADRB1 (Canis familiaris)
RHEA:24710	skos:altLabel	"UDP-Ara4O aminotransferase"
RHEA:24710	skos:altLabel	"UDP-4-amino-4-deoxy-L-arabinose aminomutase"
RHEA:24710	skos:prefLabel	"UDP-4-amino-4-deoxy-L-arabinose aminotransferase"
RHEA:24710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose = L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose
RHEA:24710	skos:altLabel	"UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase"
RHEA:24710	skos:altLabel	"UDP-L-Ara4N transaminase"
RHEA:24710	skos:altLabel	"UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase"
RHEA:24710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-4-amino-4-deoxy-L-arabinose aminotransferase"
RHEA:45447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate
REACT:R-MMU-158766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Mus musculus)
REACT:R-CFA-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Canis familiaris)
REACT:R-DRE-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Danio rerio)
REACT:R-SCE-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Saccharomyces cerevisiae)
REACT:R-HSA-8853793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET complexes bind GRB2 (Homo sapiens)
REACT:R-DRE-976991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor ligands bind the prolactin receptor (Danio rerio)
REACT:R-MMU-982778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone binds the growth hormone receptor (Mus musculus)
RHEA:47098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate => (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
RHEA:62415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H2O <=> acetyl-CoA + vanillin
RHEA:31560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactose + NAD(+) => H(+) + L-galactono-1,4-lactone + NADH
REACT:R-DME-70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer oxidises LACT to PYR (Drosophila melanogaster)
GO:0033759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity
GO:0033759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavone synthase activity
GO:0033759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FNS I
GO:0033759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavone synthase I activity
REACT:R-SSC-8864105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 binds ERBB2:EGFR heterodimers (Sus scrofa)
RHEA:38913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-desgluco-avenacoside B + D-glucose => avenacoside B + H2O
REACT:R-HSA-5138432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 is phosphorylated by PKC (Homo sapiens)
RHEA:68131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + phytol <=> a fatty acid phytyl ester + CoA
RHEA:19010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-acylpyruvate + H2O => a carboxylate + H(+) + pyruvate
REACT:R-MMU-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Mus musculus)
REACT:R-SCE-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Saccharomyces cerevisiae)
RHEA:51049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + A => AH2 + androst-4-ene-3,17-dione
RHEA:42004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH
REACT:R-BTA-5654646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Bos taurus)
REACT:R-HSA-9028524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H3, NRIP1 bind the PCK1 gene (Homo sapiens)
RHEA:68226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + kainate lactone + succinate => 2-oxoglutarate + H(+) + O2 + prekainate
REACT:R-HSA-164527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Annealing of 3'-end of unwound transfer RNA primer with genomic RNA (Homo sapiens)
RHEA:23494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactosamine => UDP-alpha-D-glucosamine
REACT:R-HSA-1358798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)
REACT:R-DRE-190256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to FGF (Danio rerio)
REACT:R-XTR-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Xenopus tropicalis)
RHEA:34993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-ornithine(out) => L-arginine(out) + L-ornithine(in)
RHEA:28327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + wogonin 7-O-beta-D-glucuronate => D-glucuronate + H(+) + wogonin
REACT:R-MMU-6785821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS5,(SOCS1) bind IL4RA (Mus musculus)
GO:0102822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3'-O-methyltransferase activity
REACT:R-XTR-9648017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 binds to microtubules (Xenopus tropicalis)
REACT:R-HSA-9729279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein is ADP-ribosylated (Homo sapiens)
REACT:R-RNO-446130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 2 binds Interleukin 1 (Rattus norvegicus)
RHEA:27840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-aminobiphenyl-2,3-diol + NAD(+) => 9H-carbazole + H(+) + NADH + O2
REACT:R-MMU-388833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CTLA-4 (Mus musculus)
REACT:R-HSA-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Homo sapiens)
RHEA:71777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(in) + H(+)(in) => acetoacetate(out) + H(+)(out)
REACT:R-HSA-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Homo sapiens)
REACT:R-MMU-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Mus musculus)
REACT:R-HSA-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Homo sapiens)
RHEA:12767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate
REACT:R-DRE-5218832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds PAK2 (Danio rerio)
RHEA:40278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanedioyl-CoA + O2 <=> (2E)-hexadecenedioyl-CoA + H2O2
REACT:R-MMU-2130336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial proteolyis of Ii by aspartic proteases to lip22 (Mus musculus)
REACT:R-DME-548815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Drosophila melanogaster)
REACT:R-DRE-6805103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates TP53 (Danio rerio)
REACT:R-HSA-350319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of vimentin at IDVD (259) (Homo sapiens)
REACT:R-DRE-964773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXGR1 binds 2OG (Danio rerio)
RHEA:24464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phospho-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate
REACT:R-DRE-164617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of Extended Telomeric Chromosome End (Danio rerio)
REACT:R-MMU-2395302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysino-5-ketonorleucine cross-links (Mus musculus)
REACT:R-DME-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Drosophila melanogaster)
RHEA:12004	skos:prefLabel	"indoxyl-UDPG glucosyltransferase"
RHEA:12004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoxyl + UDP-alpha-D-glucose = H(+) + indican + UDP
RHEA:12004	skos:altLabel	"indoxyl-UDPG-glucosyltransferase"
RHEA:12004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indoxyl-UDPG glucosyltransferase"
GO:0016420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyltransferase activity
REACT:R-BTA-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Bos taurus)
REACT:R-XTR-174251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Xenopus tropicalis)
REACT:R-SSC-442273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV1 is a GEF for Rho/Rac family GTPases (Sus scrofa)
RHEA:68284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + L-seryl-[protein] = CoA + O-hexanoyl-L-seryl-[protein]
REACT:R-RNO-5668534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Rattus norvegicus)
RHEA:51138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2
RHEA:35594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + n sulfur <=> H(+) + hydrogen sulfide + (n-1) sulfur
RHEA:18785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + gibberellin A12 aldehyde + H2O = AH2 + gibberellin A12 + H(+)
REACT:R-XTR-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Xenopus tropicalis)
REACT:R-BTA-5665727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds CDC42:GTP (Bos taurus)
GO:0043731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate 3-monooxygenase activity
RHEA:10420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + taurine = L-alanine + sulfoacetaldehyde
RHEA:51425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate
RHEA:56681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Sus scrofa)
RHEA:70221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pregnenolone sulfatase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 3-sulfatase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steryl-sulfate sulfohydrolase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol sulfatase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenolic steroid sulfatase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid sulfatase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid sulfate sulfohydrolase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylsulfatase C activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steryl-sulfatase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydroepiandrosterone sulfate sulfatase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steryl-sulphatase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydroepiandrosterone sulfatase activity
GO:0004773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-beta-hydroxysteroid sulfate sulfatase activity
REACT:R-GGA-5668629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Gallus gallus)
REACT:R-XTR-417843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y13 binds ADP (Xenopus tropicalis)
RHEA:41270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)-sphing-4-enine <=> (15Z)-tetracosenoate + sphing-4-enine
REACT:R-CFA-9029150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)
REACT:R-BTA-139893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Granzyme-B activates BID by cleavage (Bos taurus)
REACT:R-HSA-400492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 hydrolyzes proGIP to GIP (Homo sapiens)
REACT:R-BTA-6813740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDE1 hydrolyzes GroPIns (Bos taurus)
GO:0047049	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-hydroxy fatty acid oxidase
GO:0047049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-fatty acid dehydrogenase activity
GO:0047049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-2-hydroxy fatty acid dehydrogenase activity
GO:0047049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-hydroxystearate:NAD+ oxidoreductase activity
GO:0047049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-fatty-acid dehydrogenase activity
RHEA:63827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate <=> aspulvinone E + H2O
GO:0016900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a disulfide as acceptor"
GO:0016900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor
GO:0016900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor
GO:0016900	skos:prefLabel	"With a disulfide as acceptor"
REACT:R-SPO-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Schizosaccharomyces pombe)
RHEA:62620	skos:altLabel	"thioredoxin peroxidase"
RHEA:62620	skos:prefLabel	"thioredoxin-dependent peroxiredoxin"
RHEA:62620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O
RHEA:62620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thioredoxin-dependent peroxiredoxin"
RHEA:43203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-164840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP and Pi bind to ATPase (Bos taurus)
REACT:R-BTA-376851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Bos taurus)
RHEA:12873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoate + NADP(+) = 4-methyl-2-oxopentanoate + H(+) + NADPH
EC:2.7.8.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphomannan mannosephosphotransferase"
EC:2.7.8.9	skos:prefLabel	"phosphomannan mannosephosphotransferase"
REACT:R-CFA-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)
REACT:R-DRE-193070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)
GO:0019904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein domain-specific binding
GO:0019904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein domain specific binding
REACT:R-HSA-1222342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroperoxyl enters the bacterium (Homo sapiens)
RHEA:47756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:68002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chloride + chloroethene + H(+) => 1,1-dichloroethene + AH2
RHEA:31244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) => (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH
RHEA:38893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + sphing-4-enine => H2O + N-hexadecanoylsphing-4-enine
REACT:R-BTA-419011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectins (Bos taurus)
RHEA:65385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)
REACT:R-RNO-6814374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kazrin binds periplakin (Rattus norvegicus)
REACT:R-RNO-9679421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCD1 binds PDCD1 inhibitors (Rattus norvegicus)
REACT:R-GGA-982778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone binds the growth hormone receptor (Gallus gallus)
REACT:R-HSA-8878130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3 (Homo sapiens)
RHEA:35793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + kanamycin X + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine
RHEA:20607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + uracil => cytosine + H(+) + H2O
REACT:R-SCE-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Saccharomyces cerevisiae)
REACT:R-GGA-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Gallus gallus)
RHEA:16586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9694333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3CLp forms a homodimer (Homo sapiens)
REACT:R-HSA-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Homo sapiens)
RHEA:55389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2
REACT:R-BTA-446634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 is activated by autophosphorylation (Bos taurus)
RHEA:65391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP
REACT:R-CEL-2024108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some HSPGs are secreted to the plasma membrane (Caenorhabditis elegans)
REACT:R-XTR-110355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MUTYH glycosylase by APEX1 at the AP site (Xenopus tropicalis)
REACT:R-MMU-3000335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Mus musculus)
REACT:R-XTR-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Xenopus tropicalis)
REACT:R-XTR-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Xenopus tropicalis)
REACT:R-CFA-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Canis familiaris)
RHEA:35003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fucose(in) = L-fucose(out)
REACT:R-MMU-9691215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFR2 dimer (Mus musculus)
REACT:R-RNO-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Rattus norvegicus)
RHEA:69302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl isothiocyanate + sulfate => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate
REACT:R-HSA-9635424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rv3364c binds cathepsin G (Homo sapiens)
GO:0004938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha2 adrenoceptor
GO:0004938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha2-adrenergic receptor activity
REACT:R-HSA-3781832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MPI does not  isomerize Fru6P to Man6P (Homo sapiens)
RHEA:37642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:51969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate
RHEA:23969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + H2O + NAD(+) => (E)-ferulate + 2 H(+) + NADH
RHEA:10815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + N-succinyl-L-glutamate + NADH
REACT:R-XTR-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Xenopus tropicalis)
REACT:R-HSA-452097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruited STAT5 is phosphorylated (Homo sapiens)
REACT:R-SSC-2471842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XXV ectomain shedding (Sus scrofa)
REACT:R-MMU-8987080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Mus musculus)
GO:0062104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pumilio-response element binding
GO:0062104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRE binding
REACT:R-HSA-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Homo sapiens)
RHEA:70661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + N,N-dimethylglycine(out) => H(+)(in) + N,N-dimethylglycine(in)
RHEA:62252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + Zn(2+)(out) = 2 hydrogencarbonate(in) + Zn(2+)(in)
REACT:R-DME-194121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-GGA-3108203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO2,3 (Gallus gallus)
REACT:R-HSA-994020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF1 binds the promoters of Interferon alpha and beta (Homo sapiens)
REACT:R-SSC-1112602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Sus scrofa)
RHEA:27859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-GMP + H2O => 3'-GMP + H(+)
REACT:R-BTA-173680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C5 (Bos taurus)
RHEA:55793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-one + H(+) + NADH + O2 => 1-hydroxy-2-butanone + H2O + NAD(+)
RHEA:47974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose
RHEA:72167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurohyodeoxycholate(out) = 2 Na(+)(in) + taurohyodeoxycholate(in)
REACT:R-XTR-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Xenopus tropicalis)
RHEA:52040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine = 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine
REACT:R-SSC-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)
REACT:R-MMU-416698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA5A binds to PLXNB3 (Mus musculus)
RHEA:31700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al
GO:0047018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-acetaldehyde reductase (NADH)"
GO:0047018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetaldehyde reductase (NADH) activity
GO:0047018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleacetaldehyde reductase activity
GO:0047018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-ethanol + NAD(+) = H(+) + indole-3-acetaldehyde + NADH
GO:0047018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(indol-3-yl)ethanol:NAD+ oxidoreductase activity
GO:0047018	skos:altLabel	"indoleacetaldehyde reductase"
GO:0047018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-ethanol:NAD+ oxidoreductase activity
GO:0047018	skos:prefLabel	"indole-3-acetaldehyde reductase (NADH)"
RHEA:39140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA
REACT:R-CEL-375768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Caenorhabditis elegans)
REACT:R-GGA-434004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viral dsRNA binds the toll-like receptor 3 (TLR3) (Gallus gallus)
REACT:R-RNO-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Rattus norvegicus)
REACT:R-RNO-5625421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The anterograde IFT train dissociates (Rattus norvegicus)
RHEA:67386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DDI-1855205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Dictyostelium discoideum)
RHEA:42367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 2-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-HSA-73635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Homo sapiens)
REACT:R-RNO-5618093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP90 (Rattus norvegicus)
RHEA:46775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)
RHEA:63980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-thiouridine + ATP = 4-thiouridine 5'-phosphate + ADP + H(+)
RHEA:60701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline
REACT:R-RNO-5263616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeO2H is reduced to MeSeOH by TXNRD1 (Rattus norvegicus)
REACT:R-DME-187688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Drosophila melanogaster)
REACT:R-CFA-5625717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PKN1 binds androgen receptor (AR) (Canis familiaris)
RHEA:31316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GDP-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)
REACT:R-BTA-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Bos taurus)
REACT:R-CFA-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Canis familiaris)
REACT:R-RNO-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Rattus norvegicus)
RHEA:68943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) + tellurite(in) <=> Na(+)(out) + tellurite(out)
RHEA:10081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrophloroglucinol + NADP(+) => 1,3,5-trihydroxybenzene + NADPH
REACT:R-SCE-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Saccharomyces cerevisiae)
REACT:R-BTA-1467269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins bind microbial membranes causing disruption (Bos taurus)
REACT:R-HSA-193709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
RHEA:31370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 nitrite <=> H2O + nitrate + 2 nitric oxide
REACT:R-SPO-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Schizosaccharomyces pombe)
REACT:R-GGA-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Gallus gallus)
REACT:R-XTR-5693584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Xenopus tropicalis)
GO:0044587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellopentaose binding
GO:0033966	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-benzylformamide amidohydrolase activity
GO:0033966	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NfdA
GO:0033966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-substituted formamide deformylase activity
GO:0052661	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-propane-1,2-diol:NAD+ oxidoreductase activity
GO:0052661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-lactaldehyde reductase activity
GO:0052661	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lactaldehyde:propanediol oxidoreductase activity
REACT:R-XTR-5692755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates MAPK6 (Xenopus tropicalis)
RHEA:46651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxy-3-oxochol-4-en-22-oyl-CoA <=> androst-4-ene-3,17-dione + propanoyl-CoA
REACT:R-CFA-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Canis familiaris)
RHEA:15226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-alpha-D-glucose
REACT:R-GGA-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Gallus gallus)
REACT:R-HSA-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Homo sapiens)
REACT:R-BTA-5336182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37 binds prosaptide (Bos taurus)
REACT:R-GGA-3000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BORA binds PLK1 and AURKA (Gallus gallus)
REACT:R-BTA-177941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:GAB1 binds to phosphorylated EGFR (Bos taurus)
REACT:R-CEL-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Caenorhabditis elegans)
GO:0003980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGGT activity
GO:0003980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b (Homo sapiens)
GO:0003980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:glycoprotein glucosyltransferase activity
GO:0008288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	boss receptor activity
GO:0008288	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sevenless receptor activity
REACT:R-SSC-917888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF binds 2Fe3+ to form holoTF (Sus scrofa)
REACT:R-DRE-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Danio rerio)
GO:0045442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-lactam hydroxylase activity
GO:0045442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DACS
GO:0045442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetylcephalosporin C synthase activity
GO:0045442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetoxycephalosporin-C hydroxylase activity
GO:0045442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAOC hydroxylase activity
GO:0045442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-methylcephem hydroxylase activity
GO:0045442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
GO:0045442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetoxycephalosporin C hydroxylase activity
REACT:R-DME-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Drosophila melanogaster)
RHEA:25833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-chiro-inositol + NAD(+) => H(+) + NADH + scyllo-inosine
RHEA:16217	skos:prefLabel	"L-arabinonolactonase"
RHEA:16217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arabinonolactonase"
RHEA:16217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arabinono-1,4-lactone = H(+) + L-arabinonate
RHEA:28273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + spermidine <=> CoA + H(+) + N(8)-acetylspermidine
RHEA:40055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trioctanoylglycerol + H2O = 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate
RHEA:20423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + D-glucose 6-phosphate => alpha-maltose 6'-phosphate + H2O
REACT:R-SSC-5653754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Sus scrofa)
REACT:R-GGA-5654406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Gallus gallus)
REACT:R-CFA-9646679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded proteins bind vimentin to form aggresome (Canis familiaris)
REACT:R-DDI-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Dictyostelium discoideum)
REACT:R-RNO-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Rattus norvegicus)
REACT:R-HSA-8979082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ETS2 binds p16INK4A promoter (Homo sapiens)
RHEA:51309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl-[F-actin] + NADPH + O2 => H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)
REACT:R-DRE-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Danio rerio)
RHEA:21061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dichloroaniline + malonyl-CoA => CoA + N-(3,4-dichlorophenyl)malonamate
RHEA:53437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-6810472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT13 hydrolyses AP6A to AP4 and ADP (Danio rerio)
REACT:R-GGA-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Gallus gallus)
GO:0050181	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	12,13-diacylphorbate 12-acylhydrolase activity
GO:0050181	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDEH
GO:0050181	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phorbol-12,13-diester 12-ester hydrolase activity
GO:0050181	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diacylphorbate 12-hydrolase activity
GO:0050181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phorbol-diester hydrolase activity
REACT:R-PFA-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Plasmodium falciparum)
REACT:R-RNO-211190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of DFF45 (117) (Rattus norvegicus)
RHEA:10378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Cu(2+)(out) + H(+) + phosphate => ATP + Cu(2+)(in) + H2O
RHEA:22628	skos:altLabel	"phosphoribosylaminoimidazole-succinocarboxamide synthetase"
RHEA:22628	skos:altLabel	"4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase"
RHEA:22628	skos:altLabel	"5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase"
RHEA:22628	skos:altLabel	"phosphoribosylaminoimidazolesuccinocarboxamide synthetase"
RHEA:22628	skos:altLabel	"SAICAR synthase"
RHEA:22628	skos:altLabel	"4-(N-succinocarboxamide)-5-aminoimidazole synthetase"
RHEA:22628	skos:altLabel	"SAICAR synthetase"
RHEA:22628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosylaminoimidazolesuccinocarboxamide synthase"
RHEA:22628	skos:altLabel	"SAICARs"
RHEA:22628	skos:altLabel	"phosphoribosylaminoimidazole-succinocarboxamide synthase"
RHEA:22628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate
RHEA:22628	skos:prefLabel	"phosphoribosylaminoimidazolesuccinocarboxamide synthase"
REACT:R-HSA-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)
REACT:R-RNO-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)
RHEA:56825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cyclooctat-9-ene-5,7-diol + O2 => A + cyclooctatin + H2O
RHEA:38271	skos:altLabel	"mesaconyl-C4-CoA hydratase"
RHEA:38271	skos:altLabel	"mesaconyl-coenzyme A hydratase"
RHEA:38271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O
RHEA:38271	skos:prefLabel	"3-methylfumaryl-CoA hydratase"
RHEA:38271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-methylfumaryl-CoA hydratase"
GO:0047909	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity
GO:0047909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactolipid O-acyltransferase activity
GO:0047909	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactolipid:galactolipid acyltransferase activity
REACT:R-SSC-3095889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC dealkylates RCbl (Sus scrofa)
REACT:R-SSC-167427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid dissociates from MOR (Sus scrofa)
REACT:R-DRE-9629149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves thymine glycol from damaged DNA (Danio rerio)
REACT:R-SPO-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Schizosaccharomyces pombe)
REACT:R-PFA-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Plasmodium falciparum)
REACT:R-CFA-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Canis familiaris)
REACT:R-XTR-212642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamine transport into neurons (Xenopus tropicalis)
RHEA:66703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate
REACT:R-CFA-5685602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCR3LG1 binds NCR3 (Canis familiaris)
RHEA:54545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine => 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-GGA-983266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins bind microtubules (Gallus gallus)
RHEA:60884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)
REACT:R-BTA-9015379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (compounds) binds IIa (Bos taurus)
REACT:R-RNO-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Rattus norvegicus)
REACT:R-BTA-9654525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Bos taurus)
REACT:R-DRE-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Danio rerio)
REACT:R-DRE-202717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of CEACAMs (Danio rerio)
REACT:R-MMU-9733545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids bind ALB (Mus musculus)
REACT:R-BTA-5625796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM4C binds KLK2 and KLK3 promoters (Bos taurus)
REACT:R-DRE-1504186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL recruits GSK3beta:AXIN1 to the receptor complex (Danio rerio)
RHEA:22010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-succinyl-L-homoserine => L-homoserine + succinyl-CoA
REACT:R-SSC-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Sus scrofa)
GO:0047833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol dehydrogenase (acceptor) activity
GO:0047833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-sorbitol:acceptor 1-oxidoreductase activity
GO:0047833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol dehydrogenase activity
GO:0047833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-sorbitol:(acceptor) 1-oxidoreductase activity
REACT:R-CFA-9647645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD oligomerizes into arc-, slit-shaped structures (Canis familiaris)
RHEA:62356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate
REACT:R-SCE-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)
REACT:R-RNO-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Rattus norvegicus)
RHEA:69775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = beta-ylangene + diphosphate
REACT:R-CEL-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Caenorhabditis elegans)
REACT:R-DRE-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Danio rerio)
RHEA:61617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-proline betaine + NADH + O2 => formaldehyde + H2O + N-methyl-L-proline + NAD(+)
RHEA:41251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate
RHEA:42921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(1498) in 16S rRNA => H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine
REACT:R-BTA-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Bos taurus)
REACT:R-BTA-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Bos taurus)
REACT:R-CFA-8949661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Canis familiaris)
REACT:R-SSC-994137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Sus scrofa)
REACT:R-RNO-1482695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Rattus norvegicus)
RHEA:63531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + H2O2 <=> [thioredoxin]-disulfide + 2 H2O
RHEA:10844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxamine--oxaloacetate transaminase"
RHEA:10844	skos:prefLabel	"pyridoxamine--oxaloacetate transaminase"
RHEA:10844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + pyridoxamine = L-aspartate + pyridoxal
RHEA:10844	skos:altLabel	"Pyridoxamine--oxaloacetate aminotransferase"
RHEA:52446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose
REACT:R-DME-209330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BSK kinase and the AP-1 transcription factor, JRA:KAY, bind to CKA scaffolding protein in the nucleus (Drosophila melanogaster)
REACT:R-RNO-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Rattus norvegicus)
REACT:R-HSA-6802921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
REACT:R-CEL-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Caenorhabditis elegans)
REACT:R-XTR-5690991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Xenopus tropicalis)
RHEA:31547	skos:altLabel	"dehydrosqualene synthase"
RHEA:31547	skos:altLabel	"DAP synthase"
RHEA:31547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4,4'-diapophytoene synthase"
RHEA:31547	skos:altLabel	"C30 carotene synthase"
RHEA:31547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate
RHEA:31547	skos:prefLabel	"4,4'-diapophytoene synthase"
RHEA:52606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP
RHEA:70357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biuret + CO2 => 1-carboxybiuret + H(+)
REACT:R-DRE-3266557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I cleaves iC3b (Danio rerio)
RHEA:36298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltose 6'-phosphate + H2O <=> D-maltose + phosphate
RHEA:37663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP
RHEA:37663	skos:prefLabel	"protein O-mannose beta-1,4-N-acetylglucosaminyltransferase"
RHEA:37663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein O-mannose beta-1,4-N-acetylglucosaminyltransferase"
REACT:R-BTA-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Bos taurus)
REACT:R-CFA-448673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of caspase-1 p10/p20 dimer (Canis familiaris)
REACT:R-GGA-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Gallus gallus)
REACT:R-BTA-9692376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL2 binds BCL2 antagonists (Bos taurus)
REACT:R-DME-5654224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds PLCG1 (Drosophila melanogaster)
GO:0035731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNDGIC binding
GO:0035731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dinitrosyl-diglutathionyl-iron complex binding
GO:0035731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dinitrosyl-iron complex binding
GO:0035731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNIC binding
REACT:R-HSA-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Homo sapiens)
REACT:R-PFA-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Plasmodium falciparum)
RHEA:50694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-maltose 1-phosphate + H(+) => ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate
REACT:R-BTA-216723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)
REACT:R-RNO-3165230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC52A1,2,3 transport RIB from extracellular region to cytosol (Rattus norvegicus)
REACT:R-HSA-1112727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serine phosphorylation of STATs (Homo sapiens)
RHEA:71893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide => dGMP + NAD(+)
RHEA:63499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrobenzaldehyde + H(+) + NADPH <=> 4-nitrobenzyl alcohol + NADP(+)
RHEA:35675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine + tetradecanoyl-CoA = 3-oxohexadecasphinganine + CO2 + CoA
REACT:R-DRE-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Danio rerio)
RHEA:10807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin <=> (R)-allantoin
REACT:R-CFA-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Canis familiaris)
REACT:R-HSA-428531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to NCK (Homo sapiens)
REACT:R-CEL-9649108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer binds 5HT (Caenorhabditis elegans)
REACT:R-GGA-8869580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEK binds TFAP2A homodimers (Gallus gallus)
RHEA:38394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)
GO:0062063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binding
REACT:R-MMU-5624494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 binds p21 RAS:GTP (Mus musculus)
REACT:R-MMU-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Mus musculus)
REACT:R-BTA-9008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylation (Bos taurus)
REACT:R-CFA-75080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC A complex (Canis familiaris)
RHEA:48082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:69759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + nonanal = 2 H(+) + NADH + nonanoate
RHEA:37433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine => 12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine
REACT:R-SSC-2029452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to phosphorylated ITAMs (Sus scrofa)
REACT:R-GGA-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Gallus gallus)
REACT:R-CFA-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Canis familiaris)
RHEA:68160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-750993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (q) reassociates with G beta:gamma (Mus musculus)
GO:0047715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:hypotaurocyamine N-phosphotransferase activity
GO:0047715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypotaurocyamine kinase activity
REACT:R-HSA-76494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POR reduces CYP450:Fe3+ to CYP450:Fe2+ (Homo sapiens)
RHEA:63122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoate + NH4(+) => (11Z)-eicosenamide + H2O
RHEA:11094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 3-phosphate
REACT:R-CEL-210430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of L-Glutamate at the synapse (Caenorhabditis elegans)
REACT:R-SSC-5672957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates KSR1 (Sus scrofa)
RHEA:34415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O
REACT:R-DRE-5687123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S115 MAPKAPK5 translocates to the cytosol (Danio rerio)
REACT:R-DME-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Drosophila melanogaster)
RHEA:28101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GDP <=> AMP + guanosine 3',5'-bis(diphosphate)
GO:0030564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA 2'-O-ribose methylation guide activity
REACT:R-BTA-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Bos taurus)
REACT:R-SSC-751001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (i) reassociates with G beta:gamma (Sus scrofa)
REACT:R-DRE-6799191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Danio rerio)
REACT:R-RNO-5218822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK binds BCAR1 and or PXN (Rattus norvegicus)
REACT:R-SSC-192123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates CHOL (Sus scrofa)
RHEA:28733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-leucine(out) => H(+)(out) + L-leucine(in)
RHEA:56016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)
RHEA:60684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) = (11R)-dihydroartemisinate + 2 H(+) + NADPH
REACT:R-HSA-8862280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
REACT:R-RNO-1614605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is dioxygenated (Rattus norvegicus)
RHEA:35282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hexadecanoyl-CoA <=> 3-oxooctadecanoyl-CoA + CoA
REACT:R-BTA-2024108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some HSPGs are secreted to the plasma membrane (Bos taurus)
REACT:R-CFA-9614273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGRG heterodimer translocates to plasma membrane (Canis familiaris)
REACT:R-BTA-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Bos taurus)
REACT:R-CEL-6800298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF dimer binds MET (Caenorhabditis elegans)
REACT:R-HSA-5659899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SI does not hydrolyze maltotriose (Homo sapiens)
REACT:R-SPO-174367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCL ligates L-Glu to L-Cys (Schizosaccharomyces pombe)
REACT:R-SPO-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Schizosaccharomyces pombe)
RHEA:10564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate 4-methyl ester = H(+) + methanol + oxaloacetate
RHEA:10564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-methyloxaloacetate esterase"
RHEA:10564	skos:prefLabel	"4-methyloxaloacetate esterase"
REACT:R-SSC-9018594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds LBR (Sus scrofa)
REACT:R-MMU-937075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated TAK1 leaves activated TLR receptor complex (Mus musculus)
GO:0035049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juvenile hormone acid methyltransferase activity
GO:0140492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal-dependent ubiquitinyl-like hydrolase activity
GO:0140492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal-dependent ubiquitin-like hydrolase activity
GO:0140492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal-dependent deubiquitinase activity
RHEA:34146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabinerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2
RHEA:71210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide(out) + 2 Na(+)(out) <=> iodide(in) + 2 Na(+)(in)
REACT:R-SSC-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Sus scrofa)
EC:3.1.21.10	skos:altLabel	"SpCCe1 Holliday junction resolvase"
EC:3.1.21.10	skos:altLabel	"Holliday junction-resolving endoribonuclease"
EC:3.1.21.10	skos:altLabel	"Holliday junction nuclease"
EC:3.1.21.10	skos:altLabel	"endo X3"
EC:3.1.21.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"crossover junction endodeoxyribonuclease"
EC:3.1.21.10	skos:altLabel	"cruciform-cutting endonuclease"
EC:3.1.21.10	skos:altLabel	"endonuclease X3"
EC:3.1.21.10	skos:prefLabel	"crossover junction endodeoxyribonuclease"
EC:3.1.21.10	skos:altLabel	"resolving enzyme CCE1"
EC:3.1.21.10	skos:altLabel	"RusA Holliday junction resolvase"
EC:3.1.21.10	skos:altLabel	"RuvC endonuclease"
EC:3.1.21.10	skos:altLabel	"Hje endonuclease"
EC:3.1.21.10	skos:altLabel	"endonuclease RuvC"
EC:3.1.21.10	skos:altLabel	"Holliday junction-cleaving endonuclease"
EC:3.1.21.10	skos:altLabel	"Holliday junction endonuclease CCE1"
EC:3.1.21.10	skos:altLabel	"RusA endonuclease"
EC:3.1.21.10	skos:altLabel	"crossover junction endoribonuclease"
EC:3.1.21.10	skos:altLabel	"endonuclease VII"
EC:3.1.21.10	skos:altLabel	"Holliday junction resolvase"
RHEA:64232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + holo-[ACP] + 8 malonyl-CoA = atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O
GO:0008191	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloproteinase inhibitor
GO:0008191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloendopeptidase inhibitor activity
GO:0008191	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloprotease inhibitor
REACT:R-DME-174122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Drosophila melanogaster)
REACT:R-HSA-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Homo sapiens)
REACT:R-MMU-397835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:Gq (active) dissociate (Mus musculus)
REACT:R-RNO-5661122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2R3-histone H3 (Rattus norvegicus)
REACT:R-DRE-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Danio rerio)
REACT:R-HSA-9010396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT1 binds COL4A5 (Homo sapiens)
REACT:R-MMU-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Mus musculus)
RHEA:14683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminophenoxazin-3-one + AH2 + 2 H2O => 2 2-aminophenol + A + O2
RHEA:21947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-cellobiose <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)
REACT:R-BTA-445064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by VAV2 (Bos taurus)
REACT:R-BTA-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Bos taurus)
REACT:R-SSC-5610733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Sus scrofa)
REACT:R-MMU-9011543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCA binds PDK2 (Mus musculus)
RHEA:12977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoamidase"
RHEA:12977	skos:prefLabel	"phosphoamidase"
RHEA:12977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-phosphocreatine = creatine + phosphate
REACT:R-HSA-9021919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2:CREB1 binds SST gene promoter (Homo sapiens)
REACT:R-BTA-5654422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS2 (Bos taurus)
RHEA:67086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + hexacosanoate(out) + phosphate => ATP + H2O + hexacosanoate(in)
REACT:R-XTR-5620921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Xenopus tropicalis)
REACT:R-BTA-6806613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin tetramers bind to form unit length filaments (Bos taurus)
RHEA:22681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + H(+) + H2O => dUTP + NH4(+)
REACT:R-HSA-2161735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGC2 is isomerised to PGB2 (Homo sapiens)
REACT:R-XTR-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Xenopus tropicalis)
RHEA:17156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-D-glucose <=> CDP-4-dehydro-6-deoxy-D-glucose + H2O
REACT:R-DRE-5578883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Danio rerio)
GO:0018730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaconate CoA-transferase activity
GO:0018730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:(E)-glutaconate CoA-transferase activity
RHEA:62302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH
REACT:R-MMU-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Mus musculus)
REACT:R-SSC-1454791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP7, MMP9 bind CD44 (Sus scrofa)
RHEA:65011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + decanoate + H(+) <=> decanoyl-AMP + diphosphate
GO:0005150	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-1, type I receptor ligand
GO:0005150	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-1 type I
GO:0005150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1, type I receptor binding
GO:0008948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalacetic acid decarboxylase activity
GO:0008948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxaloacetate beta-decarboxylase activity
GO:0008948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalate beta-decarboxylase activity
GO:0008948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxaloacetate carboxy-lyase activity
GO:0008948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate carboxy-lyase (pyruvate-forming)
GO:0008948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate decarboxylase activity
RHEA:43822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DRE-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Danio rerio)
REACT:R-SSC-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Sus scrofa)
REACT:R-XTR-5654569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS2 (Xenopus tropicalis)
RHEA:59110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol => chenodeoxycholate + octyl beta-D-glucose
REACT:R-GGA-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Gallus gallus)
REACT:R-DRE-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Danio rerio)
RHEA:33352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + sphinganine => CoA + H(+) + N-hexacosanoylsphinganine
RHEA:57531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O <=> a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)
GO:0050628	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-KPCC activity
GO:0050628	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)
GO:0050628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopropyl-CoM reductase (carboxylating) activity
GO:0050628	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity
GO:0050628	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity
RHEA:51476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + formate + H(+) = a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O
RHEA:51476	skos:altLabel	"anaerobic ribonucleoside-triphosphate reductase"
RHEA:51476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonucleoside-triphosphate reductase (formate)"
RHEA:51476	skos:prefLabel	"ribonucleoside-triphosphate reductase (formate)"
RHEA:20651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitacin B + H(+) + NADPH => 23,24-dihydrocucurbitacin B + NADP(+)
REACT:R-XTR-9692738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds HRH2 antagonists (Xenopus tropicalis)
RHEA:27876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + salicylate => isochorismate
RHEA:25948	skos:altLabel	"diacylglycerol kinase (CTP dependent)"
RHEA:25948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)
RHEA:25948	skos:altLabel	"CTP-dependent diacylglycerol kinase"
RHEA:25948	skos:altLabel	"diglyceride kinase"
RHEA:25948	skos:prefLabel	"diacylglycerol kinase (CTP)"
RHEA:25948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diacylglycerol kinase (CTP)"
RHEA:25948	skos:altLabel	"DAG kinase"
REACT:R-DRE-392051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Grb2 to pFAK:NCAM1 (Danio rerio)
REACT:R-XTR-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)
REACT:R-RNO-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Rattus norvegicus)
RHEA:62994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + tetradecanoate => H2O + tetradecamide
REACT:R-DRE-5638332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Danio rerio)
EC:1.1.3.40	skos:prefLabel	"D-mannitol oxidase"
EC:1.1.3.40	skos:altLabel	"D-arabinitol oxidase"
EC:1.1.3.40	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-mannitol oxidase"
EC:1.1.3.40	skos:altLabel	"mannitol oxidase"
EC:1.1.3.40	skos:altLabel	"D-arabitol oxidase"
REACT:R-HSA-5687091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 binds MAPKAPK5 (Homo sapiens)
REACT:R-HSA-199032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADCAM1-1 binds Integrin alpha4beta7 (Homo sapiens)
RHEA:20735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + [thioredoxin]-disulfide <=> [protein]-disulfide + [thioredoxin]-dithiol
REACT:R-HSA-1989755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CYP4A11 (Homo sapiens)
REACT:R-CFA-5423038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Canis familiaris)
REACT:R-BTA-1602374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Bos taurus)
RHEA:60379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) <=> D-glucose(in)
REACT:R-HSA-5638222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)
RHEA:46917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juvenile hormone I => H(+) + juvenile hormone I carboxylate + methanol
RHEA:18485	skos:prefLabel	"6-acetylglucose deacetylase"
RHEA:18485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-acetylglucose deacetylase"
RHEA:18485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-acetyl-D-glucose + H2O = acetate + D-glucose + H(+)
RHEA:18672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H2O <=> adenine + D-ribose
RHEA:48729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH
REACT:R-HSA-870449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 monoubiquitinates SMAD4 (Homo sapiens)
REACT:R-BTA-983138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC heterotrimer to ER exit site (Bos taurus)
REACT:R-XTR-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Xenopus tropicalis)
REACT:R-SSC-9661397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)
RHEA:11722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + 2 H(+) + N-carbamoylsarcosine + phosphate => ATP + 2 H2O + N-methylhydantoin
GO:0030233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxynucleotide transmembrane transporter activity
GO:0071815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDL binding
GO:0071815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intermediate-density lipoprotein particle binding
GO:0071815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intermediate-density lipoprotein binding
REACT:R-RNO-6781922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds UFD1L:SKP2 (Rattus norvegicus)
REACT:R-CEL-8852809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPN, CPB2 cleave C3a, C5a (Caenorhabditis elegans)
REACT:R-CFA-264435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the COP1-p53 complex (Canis familiaris)
RHEA:42241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-XTR-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Xenopus tropicalis)
REACT:R-BTA-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)
REACT:R-RNO-109341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Rattus norvegicus)
RHEA:40291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + tetradecanedioate = AMP + diphosphate + tetradecanedioyl-CoA
RHEA:25214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP
RHEA:34026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH
GO:0001179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase I general transcription initiation factor binding
GO:0001179	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA polymerase I transcription factor binding
REACT:R-DDI-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Dictyostelium discoideum)
RHEA:65591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Xenopus tropicalis)
REACT:R-HSA-9668904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18 complex (Homo sapiens)
RHEA:31268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexanoate + NADP(+) => 6-oxohexanoate + H(+) + NADPH
REACT:R-BTA-173723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C8 binds C5b:C6:C7 (Bos taurus)
RHEA:62488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-DDI-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Dictyostelium discoideum)
REACT:R-BTA-4085028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)
REACT:R-GGA-5683077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate KDM4A,B (Gallus gallus)
REACT:R-CFA-913424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
REACT:R-DME-9693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds 5HT (Drosophila melanogaster)
REACT:R-CFA-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Canis familiaris)
REACT:R-HSA-9032798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK3 activates RAC1 (Homo sapiens)
REACT:R-DRE-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Danio rerio)
RHEA:32086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + pseudaminate <=> CMP-pseudaminate + diphosphate
REACT:R-DRE-193665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYD88 dissociates (Danio rerio)
RHEA:68859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate
REACT:R-GGA-6788855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3KRP phosphorylates PsiAm, RibAm (Gallus gallus)
REACT:R-CEL-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Caenorhabditis elegans)
REACT:R-CFA-1295622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds CBL (Canis familiaris)
REACT:R-DRE-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Danio rerio)
REACT:R-RNO-9710263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GZMB cleaves GSDME (Rattus norvegicus)
RHEA:63676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH
RHEA:40738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb1 + 2 H2O <=> 2 D-glucose + gypenoside LXXV
EC:3.2.1.203	skos:altLabel	"CMCase"
EC:3.2.1.203	skos:prefLabel	"carboxymethylcellulase"
EC:3.2.1.203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxymethylcellulase"
RHEA:69239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate <=> 4-hydroxybutylnitrile + sulfate + sulfur
RHEA:15108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferide + S-adenosyl-L-homocysteine
GO:0050145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside monophosphate kinase activity
GO:0050145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-phosphate kinase activity
GO:0050145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleotide kinase activity
GO:0050145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:nucleoside-phosphate phosphotransferase activity
GO:0050145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NMP-kinase activity
RHEA:69342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-propanethial S-oxide => (E)-prop-1-en-1-SO-peroxol
REACT:R-GGA-8961021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD binds with itself to form SFTPD 12mer (Gallus gallus)
REACT:R-MMU-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Mus musculus)
REACT:R-GGA-6789092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide anion from oxygen (Gallus gallus)
REACT:R-XTR-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Xenopus tropicalis)
RHEA:25643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pulegone + H(+) + NADPH => (1R,4S)-menthone + NADP(+)
REACT:R-CEL-8938231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds CREBBP (Caenorhabditis elegans)
REACT:R-GGA-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Gallus gallus)
REACT:R-DRE-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Danio rerio)
REACT:R-HSA-9013488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEYL gene expression is stimulated by NOTCH3 (Homo sapiens)
REACT:R-MMU-549129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations into hepatic cells (Mus musculus)
RHEA:24607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theobromine
REACT:R-DRE-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Danio rerio)
RHEA:47984	skos:prefLabel	"hydroxysqualene synthase"
RHEA:47984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxysqualene synthase"
RHEA:47984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + presqualene diphosphate = diphosphate + hydroxysqualene
REACT:R-CFA-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Canis familiaris)
GO:0140897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanoreceptor activity
REACT:R-CFA-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Canis familiaris)
REACT:R-CEL-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Caenorhabditis elegans)
REACT:R-CEL-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)
REACT:R-MMU-140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor V -> factor Va + factor V activation peptide (Mus musculus)
REACT:R-MMU-200326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CK octamer] (Mus musculus)
RHEA:22234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + NADP(+) + squalene => H(+) + NADPH + presqualene diphosphate
GO:0031831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 5B receptor binding
GO:0031831	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 5B serotonin receptor ligand
GO:0031831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 5B serotonin receptor binding
REACT:R-DRE-2029465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Danio rerio)
REACT:R-RNO-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Rattus norvegicus)
REACT:R-RNO-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Rattus norvegicus)
REACT:R-MMU-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Mus musculus)
REACT:R-SPO-70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Schizosaccharomyces pombe)
RHEA:11896	skos:prefLabel	"cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase"
RHEA:11896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH
RHEA:11896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase"
RHEA:11896	skos:altLabel	"3beta-hydroxy-Delta(5)-C27-steroid oxidoreductase"
REACT:R-DDI-9639287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2 binds L-leucine and dissociates from GATOR2 (Dictyostelium discoideum)
RHEA:16871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:36224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine
RHEA:20540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + holo-[ACP] <=> (R)-4'-phosphopantetheine + apo-[ACP] + H(+)
GO:0016309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity
GO:0016309	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type II PIP kinase activity
GO:0016309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:0016309	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1-phosphatidylinositol-5-phosphate kinase
GO:0016309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP4K
REACT:R-DRE-83650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FasL:Fas binds FADD (Danio rerio)
REACT:R-MMU-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Mus musculus)
REACT:R-GGA-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Gallus gallus)
RHEA:31957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Rattus norvegicus)
RHEA:50941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) => cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)
REACT:R-CFA-2022065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPGs are secreted (Canis familiaris)
RHEA:54929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)
REACT:R-CFA-9759206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Canis familiaris)
RHEA:36328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate
GO:0042084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydrofolate-dependent methyltransferase activity
RHEA:51740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)
REACT:R-HSA-164508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)
REACT:R-GGA-74715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of insulin receptor (Gallus gallus)
REACT:R-DME-1296024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in neuroendocrine cells (Drosophila melanogaster)
REACT:R-HSA-6791227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Homo sapiens)
REACT:R-DRE-8866551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR binds components of the ERAD machinery for ubiquitination and degradation (Danio rerio)
REACT:R-PFA-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Plasmodium falciparum)
REACT:R-DME-176631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Drosophila melanogaster)
REACT:R-HSA-216043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II binds integrin alpha10beta1 (Homo sapiens)
RHEA:62874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + semiviriditoxin => (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2
REACT:R-SSC-429441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK activation by SRC (Sus scrofa)
REACT:R-HSA-1605535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SIRT3 (Homo sapiens)
RHEA:33998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-butirosin B <=> 5-oxo-L-proline + butirosin B
REACT:R-CFA-5654582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates SHC1 (Canis familiaris)
REACT:R-HSA-1222655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AhpD reactivates AhpC (Homo sapiens)
REACT:R-MMU-170978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-FRS2:CRKL binds C3G (Mus musculus)
REACT:R-HSA-193064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)
REACT:R-BTA-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Bos taurus)
REACT:R-RNO-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Rattus norvegicus)
REACT:R-XTR-194308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Xenopus tropicalis)
REACT:R-CEL-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Caenorhabditis elegans)
RHEA:32615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeraniol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH
REACT:R-RNO-5688834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds VCP (Rattus norvegicus)
REACT:R-RNO-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Rattus norvegicus)
REACT:R-BTA-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Bos taurus)
REACT:R-MMU-392870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gs activation by prostacyclin receptor (Mus musculus)
RHEA:58339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-hydroxynonen-1-ol + NADP(+) <=> a 4-hydroxynonenal + H(+) + NADPH
REACT:R-MMU-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Mus musculus)
RHEA:20782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + GDP => ATP + GMP
RHEA:54351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:45588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-fatty-acid--[acyl-carrier-protein] ligase"
RHEA:45588	skos:prefLabel	"long-chain-fatty-acid--[acyl-carrier-protein] ligase"
RHEA:45588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate
RHEA:45588	skos:altLabel	"acyl-[acyl-carrier-protein] synthetase"
REACT:R-HSA-9662823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)
GO:0102921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosylglycerate synthase activity
REACT:R-CFA-420883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins act as GEFs for G alpha-t (Canis familiaris)
REACT:R-RNO-350578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO1 interaction with ODC (Rattus norvegicus)
RHEA:67994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-1,2-dichloroethene + A + chloride + H(+) => AH2 + trichloroethene
RHEA:13888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + stipitatonate <=> CO2 + stipitatate
REACT:R-XTR-140355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS1 (Xenopus tropicalis)
GO:0050621	skos:altLabel	"L-tryptophan 2',3'-oxidase"
GO:0050621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2
GO:0050621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan 2',3'-oxidase activity
GO:0050621	skos:altLabel	"L-tryptophan alpha,beta-dehydrogenase"
GO:0050621	skos:prefLabel	"tryptophan alpha,beta-oxidase"
GO:0050621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan a,b-oxidase activity
GO:0050621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan:oxygen alpha,beta-oxidoreductase activity
GO:0050621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan alpha,beta-dehydrogenase activity
GO:0050621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan alpha,beta-oxidase activity
GO:0050621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan alpha,beta-oxidase"
REACT:R-DRE-180047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates DARPP-32 on Thr75 (Danio rerio)
REACT:R-RNO-9014433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GEFs activate RHOG (Rattus norvegicus)
REACT:R-MMU-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Mus musculus)
RHEA:59065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylluteothin + S-adenosyl-L-methionine => luteothin + S-adenosyl-L-homocysteine
RHEA:61176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]
RHEA:72068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + ATP + L-glutamate => ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate
RHEA:23239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-L-glutamate 5-O-methyl ester + H2O <=> H(+) + L-glutamyl-[protein] + methanol
RHEA:23192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-GGA-8950522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1:p-STAT4 translocates to the nucleus (Gallus gallus)
REACT:R-BTA-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)
RHEA:46468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O = ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate
RHEA:72392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + oxalate(in) => 2 hydrogencarbonate(in) + oxalate(out)
RHEA:62352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide D
REACT:R-MMU-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Mus musculus)
RHEA:54584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in 18S rRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine
REACT:R-DRE-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Danio rerio)
REACT:R-DRE-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Danio rerio)
REACT:R-CEL-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Caenorhabditis elegans)
RHEA:44192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexadecanoate + ATP + CoA = 2-methylhexadecanoyl-CoA + AMP + diphosphate
REACT:R-MMU-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Mus musculus)
RHEA:30067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H2O + NADP(+) = glycine betaine + 2 H(+) + NADPH
RHEA:15114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol
RHEA:64503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine
EC:3.6.1.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-ribose diphosphatase"
EC:3.6.1.13	skos:altLabel	"ADPR-PPase"
EC:3.6.1.13	skos:altLabel	"adenosine diphosphoribose pyrophosphatase"
EC:3.6.1.13	skos:altLabel	"ADP-ribose pyrophosphatase"
EC:3.6.1.13	skos:altLabel	"ADP-ribose phosphohydrolase"
EC:3.6.1.13	skos:prefLabel	"ADP-ribose diphosphatase"
EC:3.6.1.13	skos:altLabel	"ADP-ribose ribophosphohydrolase"
GO:0010276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + phytol = CDP + H(+) + phytyl phosphate
GO:0010276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phytol kinase"
GO:0010276	skos:prefLabel	"phytol kinase"
GO:0010276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytol kinase activity
REACT:R-DDI-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Dictyostelium discoideum)
RHEA:54561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP => a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)
RHEA:22712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylcobinamide-phosphate guanylyltransferase"
RHEA:22712	skos:altLabel	"AdoCbi kinase/AdoCbi-phosphate guanylyltransferase"
RHEA:22712	skos:prefLabel	"adenosylcobinamide-phosphate guanylyltransferase"
RHEA:22712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate
RHEA:22712	skos:altLabel	"adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase"
RHEA:52448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-BTA-2029451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Bos taurus)
REACT:R-XTR-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Xenopus tropicalis)
REACT:R-XTR-2032396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3 migrates to the nucleus (Xenopus tropicalis)
REACT:R-DME-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Drosophila melanogaster)
REACT:R-XTR-9011985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Xenopus tropicalis)
REACT:R-XTR-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Xenopus tropicalis)
REACT:R-SSC-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Sus scrofa)
REACT:R-BTA-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Bos taurus)
REACT:R-CEL-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Caenorhabditis elegans)
RHEA:17457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein]-L-cysteine + L-cysteine = [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine
REACT:R-DME-1604741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP14 (MT1-MMP) (Drosophila melanogaster)
GO:0019960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-X3-C chemokine binding
RHEA:59576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anserine + H2O = beta-alanine + N(pros)-methyl-L-histidine
RHEA:38653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-SPO-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Schizosaccharomyces pombe)
RHEA:29425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + triphosphate => ATP + diphosphate
GO:0102662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity
REACT:R-GGA-389758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)
REACT:R-HSA-1592234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GABPA (NRF2 alpha subunit) (Homo sapiens)
RHEA:19155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP => apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose
RHEA:36257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2
REACT:R-CFA-77342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Canis familiaris)
REACT:R-BTA-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Bos taurus)
RHEA:24929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + pyruvate + S-sulfanyl-L-cysteine => H2O + L-cystine
RHEA:42771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH
RHEA:64704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphenylmethanol + NAD(+) = benzophenone + H(+) + NADH
REACT:R-CEL-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Caenorhabditis elegans)
GO:1990275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	preribosome binding
RHEA:28177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> colneleate + H2O
RHEA:71664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+)(out) + succinate => a menaquinol + fumarate + 2 H(+)(in)
RHEA:47448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-GGA-8849350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Gallus gallus)
REACT:R-MMU-9700154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds SHC1 (Mus musculus)
REACT:R-SSC-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Sus scrofa)
RHEA:12428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-1,4-benzoquinone reductase"
RHEA:12428	skos:altLabel	"hydroxybenzoquinone reductase"
RHEA:12428	skos:prefLabel	"2-hydroxy-1,4-benzoquinone reductase"
RHEA:12428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)
RHEA:55435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:59375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)
REACT:R-DRE-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Danio rerio)
REACT:R-BTA-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Bos taurus)
REACT:R-HSA-5632653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds BOC:PTCH1 (Homo sapiens)
RHEA:21378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelate + CO2 => 3-(4-hydroxyphenyl)pyruvate + O2
REACT:R-GGA-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Gallus gallus)
REACT:R-BTA-76500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBXAS1 isomerises PGH2 to TXA2 (Bos taurus)
REACT:R-BTA-2162225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from small HA fragments (Bos taurus)
RHEA:56003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)
RHEA:65913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + pyruvate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine
RHEA:60206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2
REACT:R-SSC-383313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like Peptide 1 is secreted from intestinal L cells (Sus scrofa)
REACT:R-BTA-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Bos taurus)
REACT:R-BTA-8876454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND3 exchanges GTP for GDP on RAB12 (Bos taurus)
REACT:R-CFA-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Canis familiaris)
REACT:R-GGA-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Gallus gallus)
REACT:R-SCE-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Saccharomyces cerevisiae)
REACT:R-DRE-77283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Danio rerio)
REACT:R-RNO-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Rattus norvegicus)
RHEA:30530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> ADP + ATP + 2 H(+)
REACT:R-MMU-9733403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds PCSK9 inhibitors (Mus musculus)
REACT:R-HSA-2299677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARA5:ligand is endocytosed (Homo sapiens)
REACT:R-HSA-202960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of C-IAP1 (Homo sapiens)
REACT:R-PFA-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)
REACT:R-CFA-2066780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Canis familiaris)
REACT:R-XTR-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Xenopus tropicalis)
REACT:R-HSA-2247510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARCO:ligand is endocytosed (Homo sapiens)
RHEA:12356	skos:altLabel	"phosphohexoisomerase"
RHEA:12356	skos:altLabel	"phosphohexomutase"
RHEA:12356	skos:altLabel	"phosphomannoisomerase"
RHEA:12356	skos:prefLabel	"mannose-6-phosphate isomerase"
RHEA:12356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate = D-fructose 6-phosphate
RHEA:12356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannose-6-phosphate isomerase"
RHEA:12356	skos:altLabel	"phosphomannose isomerase"
REACT:R-HSA-9014834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO1,ROBO2 bind SLIT3 (Homo sapiens)
RHEA:35821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromethanopterin + H(+) + NADPH => 5,6,7,8-tetrahydromethanopterin + NADP(+)
GO:0102574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-myristoyl-ACP hydrolase activity
REACT:R-RNO-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Rattus norvegicus)
REACT:R-XTR-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Xenopus tropicalis)
REACT:R-CFA-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Canis familiaris)
REACT:R-HSA-5693925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers L-fucose to Gal1,3GlcNAc (Homo sapiens)
REACT:R-CEL-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Caenorhabditis elegans)
REACT:R-DME-2046222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Drosophila melanogaster)
RHEA:44354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dapdiamide C + H(+) + phosphate => ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate
REACT:R-SPO-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Schizosaccharomyces pombe)
REACT:R-BTA-4086392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Bos taurus)
GO:0061661	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0061661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAT10 ligase activity
REACT:R-DME-5672972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
REACT:R-BTA-6798317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Bos taurus)
RHEA:52591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH
GO:0031683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta/gamma-subunit complex binding
REACT:R-MMU-209903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline is converted to adrenaline (Mus musculus)
RHEA:63785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-SSC-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Sus scrofa)
REACT:R-CFA-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Canis familiaris)
RHEA:20460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose + NAD(+) <=> D-arabinono-1,4-lactone + H(+) + NADH
REACT:R-SPO-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)
RHEA:58189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene + dimethylallyl diphosphate + H2O => dihydroisopentenyldehydrorhodopin + diphosphate
REACT:R-SPO-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Schizosaccharomyces pombe)
RHEA:55924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:64657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapaldehyde + CoA + NADP(+) => (E)-sinapoyl-CoA + H(+) + NADPH
REACT:R-CEL-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Caenorhabditis elegans)
REACT:R-BTA-879411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Bos taurus)
GO:0000829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol heptakisphosphate kinase activity
REACT:R-CFA-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Canis familiaris)
REACT:R-CFA-174741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Canis familiaris)
REACT:R-MMU-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Mus musculus)
GO:0018641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
REACT:R-DRE-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Danio rerio)
RHEA:32286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 <=> H(+) + H2O + quinolinate
REACT:R-HSA-83803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Homo sapiens)
RHEA:60357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octanoylanthranilate => anthranilate + H(+) + octanoate
REACT:R-MMU-174451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of DNA2 endonuclease to the C strand (Mus musculus)
RHEA:33358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA
RHEA:35059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloramphenicol(in) + H(+)(out) = chloramphenicol(out) + H(+)(in)
RHEA:31602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NADH + O2 + thymine <=> (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)
REACT:R-HSA-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Homo sapiens)
REACT:R-MMU-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Mus musculus)
REACT:R-RNO-1482629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)
RHEA:19386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vomilenine => H(+) + raucaffricine + UDP
REACT:R-HSA-3247569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADI4 deiminates Histones (Homo sapiens)
REACT:R-MMU-5218824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds FYN (Mus musculus)
REACT:R-HSA-379415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)
RHEA:45644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-hexadecanoylsphing-4-enine + phosphocholine
REACT:R-MMU-5658231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs stimulate RAS GTPase activity (Mus musculus)
REACT:R-CFA-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Canis familiaris)
REACT:R-BTA-9619355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the cytosol (Bos taurus)
REACT:R-DDI-1482629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Dictyostelium discoideum)
REACT:R-MMU-422021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Mus musculus)
REACT:R-CFA-388529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholecystokinin receptors bind cholecystokinin (Canis familiaris)
RHEA:52289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
REACT:R-GGA-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Gallus gallus)
REACT:R-SCE-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Saccharomyces cerevisiae)
REACT:R-CEL-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Caenorhabditis elegans)
RHEA:21112	skos:prefLabel	"galactosylgalactosylglucosylceramidase"
RHEA:21112	skos:prefLabel	"alpha-galactosidase"
RHEA:21112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactosylgalactosylglucosylceramidase"
RHEA:21112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-galactosidase"
RHEA:21112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose
RHEA:21112	skos:altLabel	"melibiase"
GO:0016776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphotransferase activity, phosphate group as acceptor
GO:0016776	skos:prefLabel	"Phosphotransferases with a phosphate group as acceptor"
GO:0016776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphotransferases with a phosphate group as acceptor"
RHEA:72042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate(in) + orotate(out) <=> nicotinate(out) + orotate(in)
REACT:R-MMU-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Mus musculus)
RHEA:31676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + raucaffrinoline => H(+) + NADPH + perakine
REACT:R-DRE-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Danio rerio)
RHEA:13496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH
RHEA:49992	skos:prefLabel	"propane 2-monooxygenase"
RHEA:49992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"propane 2-monooxygenase"
RHEA:49992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + propane = H2O + NAD(+) + propan-2-ol
REACT:R-RNO-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Rattus norvegicus)
RHEA:47323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate <=> 3-oxo-3-phenylpropanoate + L-glutamate
EC:3.4.21.83	skos:prefLabel	"oligopeptidase B"
EC:3.4.21.83	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligopeptidase B"
EC:3.4.21.83	skos:altLabel	"protease II"
REACT:R-DRE-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Danio rerio)
REACT:R-DRE-2130486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoating of clathrin-coated vesicles and fusion with endosomes (Danio rerio)
REACT:R-DRE-5668605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2:GTP binds NOX2 complex (Danio rerio)
REACT:R-RNO-9755937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces LAN to 24,25-dhLAN (Rattus norvegicus)
RHEA:55996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
RHEA:46053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end uridylyl-uridine-RNA => a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine
RHEA:15652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamate + 2 H(+) <=> CO2 + NH4(+)
REACT:R-DDI-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Dictyostelium discoideum)
REACT:R-DRE-1295604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-RAF dissociates from S111/S120 p-SPRY2 (Danio rerio)
REACT:R-RNO-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Rattus norvegicus)
REACT:R-MMU-870437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
RHEA:11130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA => 4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA
RHEA:53411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
REACT:R-SCE-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)
RHEA:12833	skos:altLabel	"N-acyl-D-glutamate amidohydrolase"
RHEA:12833	skos:prefLabel	"N-acyl-D-glutamate deacylase"
RHEA:12833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acyl-D-glutamate deacylase"
RHEA:12833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-glutamate + H2O = a carboxylate + D-glutamate
REACT:R-SSC-9639287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2 binds L-leucine and dissociates from GATOR2 (Sus scrofa)
RHEA:29642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaose + H2O <=> alpha-D-glucose + D-maltopentaose
GO:0036122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP binding
GO:0036122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bone morphogenetic protein binding
RHEA:47785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Canis familiaris)
RHEA:13047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-5693542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RPA complexes with ssDNA at resected DNA DSBs (Homo sapiens)
REACT:R-BTA-6781897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP11 deubiquitinates NFKBIA (Bos taurus)
REACT:R-HSA-6791349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the APAF1 gene promoter (Homo sapiens)
RHEA:58783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine <=> a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine
RHEA:65139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DRE-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Danio rerio)
REACT:R-XTR-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Xenopus tropicalis)
RHEA:30488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-isoleucine => (1E,2S)-2-methylbutanal oxime + CO2 + H2O
REACT:R-XTR-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Xenopus tropicalis)
RHEA:25330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH
RHEA:55691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)
RHEA:28127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose => alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP
GO:0005347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP transmembrane transporter activity
RHEA:14671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + 2 H(+) + NADPH => D-glyceraldehyde 3-phosphate + H2O + NADP(+)
RHEA:24022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + L-arginine => 2-(N(omega)-L-arginino)succinate
RHEA:71877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + taurocholate(in) => 2 Na(+)(out) + taurocholate(out)
RHEA:62517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP
RHEA:67549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O => [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
RHEA:42515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-acetamidopentanoate + H2O <=> 5-aminopentanoate + acetate
REACT:R-HSA-446194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a third glucose to the N-glycan precursor by an ALG10 homologue (Homo sapiens)
REACT:R-MMU-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Mus musculus)
REACT:R-HSA-141159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-mediated dimerization of procaspase-8 (Homo sapiens)
REACT:R-HSA-162914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylation of Nef (Homo sapiens)
REACT:R-SPO-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)
RHEA:16615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetylarylamine + CoA => acetyl-CoA + an arylamine
RHEA:56481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
REACT:R-RNO-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Rattus norvegicus)
REACT:R-XTR-8855825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTRA1 hydrolyzes ACAN (Aggrecan) (Xenopus tropicalis)
REACT:R-MMU-2467811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of sister chromatids (Mus musculus)
REACT:R-XTR-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Xenopus tropicalis)
REACT:R-HSA-8950113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12A binds IL12B (Homo sapiens)
REACT:R-DDI-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-HSA-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Homo sapiens)
RHEA:37731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-BTA-190245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1b binds to FGF (Bos taurus)
RHEA:12766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:53333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol
RHEA:49355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Mus musculus)
REACT:R-HSA-109387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Homo sapiens)
RHEA:33198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:46962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:69324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate = 4-methylsulfanylbutyl isothionate + H(+) + sulfate
GO:0016995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxysteroid:oxygen oxidoreductase activity
GO:0016995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy steroid oxidoreductase activity
GO:0016995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 = cholest-5-en-3-one + H2O2
GO:0016995	skos:altLabel	"cholesterol-O2 oxidoreductase"
GO:0016995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholesterol oxidase"
GO:0016995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol- O2 oxidoreductase activity
GO:0016995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol:oxygen oxidoreductase activity
GO:0016995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol-O2 oxidoreductase activity
GO:0016995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol oxidase activity
GO:0016995	skos:prefLabel	"cholesterol oxidase"
RHEA:67294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one
REACT:R-HSA-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Homo sapiens)
REACT:R-RNO-982778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone binds the growth hormone receptor (Rattus norvegicus)
RHEA:17246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2
RHEA:35230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + rifampicin(in) <=> H(+)(in) + rifampicin(out)
RHEA:49103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester
RHEA:21540	skos:prefLabel	"phosphoribosylanthranilate isomerase"
RHEA:21540	skos:altLabel	"N-(5'-phosphoribosyl)anthranilate isomerase"
RHEA:21540	skos:altLabel	"PRAI"
RHEA:21540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosylanthranilate isomerase"
RHEA:21540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
REACT:R-MMU-8986258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2:ROBO1 binds CXCR4 (Mus musculus)
GO:0050264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifamycin-B-oxidase activity
GO:0050264	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rifamycin B oxidase activity
GO:0050264	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rifamycin-B:oxygen oxidoreductase activity
GO:0050264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifamycin-B oxidase activity
REACT:R-DDI-5205820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Dictyostelium discoideum)
RHEA:43078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase] => erythrodiol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CEL-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Caenorhabditis elegans)
RHEA:39485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH
REACT:R-GGA-5693602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM recognizes H2AFX-Nucleosomes (Gallus gallus)
REACT:R-SSC-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Sus scrofa)
REACT:R-DME-390835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD1,5 bind DA (Drosophila melanogaster)
RHEA:17363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonate + urea => 3-oxo-3-ureidopropanoate + H2O
RHEA:40220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonyl-CoA => CoA + H(+) + malonate
RHEA:14358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + riboflavin => ADP + FMN + H(+)
REACT:R-DRE-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Danio rerio)
REACT:R-BTA-1606807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Bos taurus)
REACT:R-XTR-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Xenopus tropicalis)
REACT:R-BTA-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
REACT:R-MMU-6803789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Mus musculus)
RHEA:52759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate
REACT:R-DRE-5675373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)
REACT:R-CEL-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Caenorhabditis elegans)
GO:0102644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monocyclic sesterterpenediol synthase activity
RHEA:38642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-DRE-265423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Fibrillin (Danio rerio)
REACT:R-HSA-9612246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds the APOE gene (Homo sapiens)
REACT:R-HSA-994169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein binds to the barbed end of elongating F-actin (Homo sapiens)
REACT:R-XTR-5649799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)
REACT:R-DRE-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Danio rerio)
REACT:R-DRE-9710354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds cardiolipin (Danio rerio)
REACT:R-SSC-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Sus scrofa)
RHEA:20223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + ADP + phosphate => (6S)-5,6,7,8-tetrahydrofolate + ATP + formate
RHEA:14404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlordecone alcohol + NADP(+) <=> chlordecone + H(+) + NADPH
REACT:R-MMU-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Mus musculus)
REACT:R-MMU-111804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)
REACT:R-DDI-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Dictyostelium discoideum)
REACT:R-XTR-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Xenopus tropicalis)
RHEA:48469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1b (d18:1(4E)) + H2O => ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate
RHEA:69933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine(in) + Na(+)(in) => inosine(out) + Na(+)(out)
RHEA:33291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-192097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Bos taurus)
RHEA:44516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)
REACT:R-MMU-8936584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)
RHEA:65120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione = L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine
RHEA:14019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-nicotinamide D-ribonucleotide + H(+) => ATP + beta-nicotinamide D-riboside
REACT:R-BTA-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)
RHEA:50035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine
REACT:R-CEL-1483002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to 1-acyl GO3P by GNPAT (Caenorhabditis elegans)
REACT:R-HSA-9690493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors on endosomes (Homo sapiens)
REACT:R-BTA-8983307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL15RA (Bos taurus)
RHEA:42572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) = 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2
GO:1905761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Skp1/Cul1/F-box protein complex binding
GO:1905761	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SCF complex substrate recognition subunit binding
GO:1905761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDL1 complex binding
GO:1905761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF complex binding
GO:1905761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRL1 complex binding
GO:1905761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cul1-RING ubiquitin ligase complex binding
GO:1905761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF ubiquitin ligase complex binding
GO:1905761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cullin-RING ligase 1 binding
REACT:R-XTR-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Xenopus tropicalis)
REACT:R-MMU-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Mus musculus)
RHEA:36677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(octacosanoyl)-sphinganine => octacosanoyl-CoA + sphinganine
REACT:R-MMU-3371467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates HSF1 (Mus musculus)
REACT:R-SSC-9603419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds SRC (Sus scrofa)
RHEA:50671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-SSC-3222237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMYD2 methylates TP53 (Sus scrofa)
RHEA:57190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + H(+) + L-arginyl-[protein] => H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]
RHEA:27378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + ATP => (2R)-2-phosphoglycerate + ADP + H(+)
RHEA:67779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O <=> a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate
REACT:R-RNO-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Rattus norvegicus)
REACT:R-BTA-416546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Bos taurus)
RHEA:40062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H2O <=> CoA + decanoate + H(+)
REACT:R-HSA-2160935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 ubiquitinates RHOA (Homo sapiens)
RHEA:66876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Bos taurus)
REACT:R-SSC-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Sus scrofa)
RHEA:25437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (E,R)-alpha-bisabolene + diphosphate
REACT:R-HSA-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Homo sapiens)
RHEA:51716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)
RHEA:13930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O => putrescine + urea
REACT:R-XTR-176664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + PAPS => estrone 3-sulfate + PAP (Xenopus tropicalis)
RHEA:29407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)
RHEA:67826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid X + 2 H(+) + UMP => a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O
REACT:R-DME-216136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CI:SU(FU) complex (Drosophila melanogaster)
RHEA:61798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + L-tryptophyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP
REACT:R-SSC-420489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parathyroid hormone receptor can bind parathyroid hormone (Sus scrofa)
REACT:R-XTR-76466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4A11 12-hydroxylates DDCX (Xenopus tropicalis)
REACT:R-MMU-177275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates DARPP-32 on Thr34 (Mus musculus)
GO:0042380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylbutenyl pyrophosphate reductase activity
GO:0042380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
REACT:R-HSA-9718360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide agonists (Homo sapiens)
RHEA:31617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine
REACT:R-DME-5229273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCN2:2,5DHBA binds Fe3+ (Drosophila melanogaster)
REACT:R-HSA-9756414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAI1 binds the CDH1 gene (Homo sapiens)
REACT:R-BTA-212263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 trimethylates histone H3 at lysine-27 (Bos taurus)
REACT:R-CFA-193964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 21-hydroxylates PROG (Canis familiaris)
REACT:R-MMU-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Mus musculus)
RHEA:31296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-hydroxypenta-2,4-dienoate => 2-oxopent-4-enoate
RHEA:28129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose <=> alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP
RHEA:25080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + CO2 => (2S)-2-isopropyl-3-oxosuccinate + H(+)
REACT:R-CFA-1604741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP14 (MT1-MMP) (Canis familiaris)
RHEA:65454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + ethyl hexanoate => ethanol + hexanoyl-CoA
RHEA:65827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Drosophila melanogaster)
REACT:R-SPO-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Schizosaccharomyces pombe)
REACT:R-DRE-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Danio rerio)
RHEA:36573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(tetradecanoyl)-sphinganine => sphinganine + tetradecanoyl-CoA
REACT:R-HSA-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)
REACT:R-CFA-1222491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoferrin scavenges iron ions (Canis familiaris)
RHEA:35382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
REACT:R-DME-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Drosophila melanogaster)
GO:0030331	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	estrogen receptor binding
GO:0030331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear estrogen receptor binding
REACT:R-CFA-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Canis familiaris)
RHEA:60527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:12083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + CoA
REACT:R-MMU-168933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of phosphorylated IRF3/IRF7 (Mus musculus)
RHEA:28287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:34639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + neopentalenolactone D
RHEA:34639	skos:prefLabel	"neopentalenolactone D synthase"
RHEA:34639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neopentalenolactone D synthase"
REACT:R-GGA-5654428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates SHC1 (Gallus gallus)
REACT:R-HSA-8870332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Homo sapiens)
RHEA:34517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP => tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine
RHEA:66620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
GO:0047330	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyphosphate-D-(+)-glucose-6-phosphotransferase activity
GO:0047330	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyphosphate:D-glucose 6-phosphotransferase activity
GO:0047330	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyphosphate glucokinase activity
GO:0047330	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyphosphate-glucose 6-phosphotransferase activity
GO:0047330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyphosphate-glucose phosphotransferase activity
RHEA:35789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + kanamycin C + UDP => paromamine + UDP-alpha-D-kanosamine
GO:1905054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels
GO:1905054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration
RHEA:53475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate
REACT:R-DRE-4341073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates PGR with SUMO1 (Danio rerio)
REACT:R-DRE-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Danio rerio)
RHEA:26025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal => 8'-apo-beta-carotenol + O2
GO:0089714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-D-mannosamine dehydrogenase activity
REACT:R-GGA-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Gallus gallus)
REACT:R-XTR-5696146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC2 deaminates TYR (Xenopus tropicalis)
REACT:R-DRE-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Danio rerio)
REACT:R-DME-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Drosophila melanogaster)
RHEA:47388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tetradecanoate ester + H2O = an aliphatic alcohol + H(+) + tetradecanoate
REACT:R-BTA-8953115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds to MGA:MAX (Bos taurus)
RHEA:50552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin C1 = prostaglandin B1
REACT:R-HSA-2399982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)
REACT:R-SSC-8938829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Sus scrofa)
REACT:R-HSA-5655263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
REACT:R-XTR-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Xenopus tropicalis)
RHEA:35875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-CFA-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Canis familiaris)
RHEA:33373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein] => alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein]
GO:0097358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-leucyl-tRNA(Leu) deacylase activity
RHEA:13170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleate => fumarate
RHEA:72937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(in) + 2 Na(+)(in) => (S)-lactate(out) + 2 Na(+)(out)
RHEA:42775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine
GO:0080081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity
REACT:R-MMU-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Mus musculus)
REACT:R-RNO-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Rattus norvegicus)
REACT:R-RNO-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Rattus norvegicus)
RHEA:32812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate(in) => benzoate(out)
RHEA:31626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-olivosyl-oleandolide + S-adenosyl-L-methionine <=> H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine
RHEA:14982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADPH
REACT:R-DME-538822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO (Drosophila melanogaster)
REACT:R-MMU-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Mus musculus)
RHEA:64580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + nerylneryl diphosphate
REACT:R-CEL-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)
RHEA:11530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein]
RHEA:36202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine
REACT:R-CEL-9691621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5 binds C5 inhibitors (Caenorhabditis elegans)
REACT:R-HSA-936947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
RHEA:33259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminoimidazole + H(+) + 2 H2O = N-formimidoylglycine + NH4(+)
RHEA:67003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisobutanophenone
RHEA:28437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] <=> ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]
REACT:R-HSA-2395764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atREs binds to nascent CM (Homo sapiens)
RHEA:56622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O
REACT:R-RNO-8939323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 binds BCL10 and Ubiquitin:E2 (Rattus norvegicus)
REACT:R-SSC-5658435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs bind RAS:GTP (Sus scrofa)
RHEA:46521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:69459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH <=> 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)
REACT:R-HSA-2033490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity (Homo sapiens)
REACT:R-RNO-8934465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds PTPN12 (Rattus norvegicus)
RHEA:61394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => ATP + N(6)-(D-psicosyl)-L-lysyl-[protein]
REACT:R-DRE-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Danio rerio)
REACT:R-RNO-1602454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proMMP9 binds TIMP1 (Rattus norvegicus)
REACT:R-CEL-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Caenorhabditis elegans)
REACT:R-BTA-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Bos taurus)
RHEA:33620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + tetradecanoate => AMP + diphosphate + tetradecanoyl-CoA
REACT:R-HSA-975180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
RHEA:13000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + galactarate <=> 2-O-[(E)-feruloyl]-D-galactarate + CoA
RHEA:20580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyaminophenol <=> aminohydroquinone
RHEA:51877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate => desmethylxanthohumol + diphosphate
REACT:R-MMU-3000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BORA binds PLK1 and AURKA (Mus musculus)
REACT:R-XTR-9708466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y486 BACH1 translocates from the nucleoplasm to the cytosol (Xenopus tropicalis)
RHEA:45879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA
RHEA:60270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine
REACT:R-DME-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Drosophila melanogaster)
REACT:R-DRE-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Danio rerio)
RHEA:44977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + propanoyl-CoA => CoA + O-propanoyl-(R)-carnitine
GO:0102109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tricaffeoyl spermidine O-methyltransferase activity
REACT:R-HSA-450187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated within the TAK1 complex (Homo sapiens)
RHEA:15658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) => 3-methylcatechol + CO2 + NADH
REACT:R-BTA-9014074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin4 (Bos taurus)
REACT:R-HSA-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)
REACT:R-HSA-193700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR ICD signals to NF-kB (Homo sapiens)
RHEA:17016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphoenolpyruvate <=> 3-phosphonopyruvate
RHEA:26515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexan-1,2-dione + H2O => 6-oxohexanoate + H(+)
REACT:R-CEL-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Caenorhabditis elegans)
REACT:R-DRE-6809320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Danio rerio)
REACT:R-XTR-1433506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APS (Xenopus tropicalis)
RHEA:62233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine(6-4)thymidine in DNA => a thymidine dimer in DNA
REACT:R-SSC-9681763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1 binds IL1R1 inhibitors (Sus scrofa)
RHEA:55599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine <=> globoside NORint + H(+) + UDP
REACT:R-MMU-73758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Mus musculus)
RHEA:32727	skos:altLabel	"condensing enzyme"
RHEA:32727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
RHEA:32727	skos:altLabel	"very-long-chain 3-ketoacyl-CoA synthase"
RHEA:32727	skos:altLabel	"very-long-chain beta-ketoacyl-CoA synthase"
RHEA:32727	skos:prefLabel	"very-long-chain 3-oxoacyl-CoA synthase"
RHEA:32727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"very-long-chain 3-oxoacyl-CoA synthase"
REACT:R-SSC-6807134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Sus scrofa)
REACT:R-HSA-9683455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 binds VHL (Homo sapiens)
REACT:R-XTR-77584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Xenopus tropicalis)
REACT:R-HSA-2197645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARF1 (SREC-I) binds ligands (Homo sapiens)
REACT:R-SSC-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Sus scrofa)
REACT:R-SSC-1483159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho is dephosphorylated to Cho by PHOSPHO1 (Sus scrofa)
REACT:R-HSA-9687724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B binds GSKi (Homo sapiens)
REACT:R-CEL-9603986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 chains to form LeA (Caenorhabditis elegans)
RHEA:68681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) => 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Homo sapiens)
REACT:R-SPO-68918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)
REACT:R-BTA-877187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates loss of intracellular K+ (Bos taurus)
RHEA:66388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + prostaglandin E2(in) = ADP + H(+) + phosphate + prostaglandin E2(out)
REACT:R-HSA-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Homo sapiens)
REACT:R-SSC-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Sus scrofa)
RHEA:12057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + H2O + NAD(+) => 4-phospho-D-erythronate + 2 H(+) + NADH
REACT:R-DME-354073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PTK2 at Y397 (Drosophila melanogaster)
REACT:R-GGA-5419281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRRF binds 55S ribosome:mRNA:tRNA (Gallus gallus)
REACT:R-XTR-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Xenopus tropicalis)
REACT:R-SSC-8981622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin:oxygen dissociates (Sus scrofa)
RHEA:19748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine
RHEA:28375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
RHEA:16915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + L-serine
REACT:R-GGA-9668902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18-RFC(7s) complex (Gallus gallus)
RHEA:33157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + phosphate => a 1-acyl-sn-glycero-3-phosphate + H2O
RHEA:39875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol
REACT:R-HSA-8877385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds intron 1 of IL2RA (CD25) gene (Homo sapiens)
RHEA:36231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
RHEA:47511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isolithocholate + NAD(+)
GO:0047171	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity
GO:0047171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucarolactone O-hydroxycinnamoyltransferase activity
REACT:R-CEL-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Caenorhabditis elegans)
REACT:R-HSA-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
REACT:R-CFA-5694433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 binds PREB (Canis familiaris)
REACT:R-CFA-2213240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of disulphide bonds in MHC II antigens (Canis familiaris)
REACT:R-GGA-163099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alignment Of The RNA Template On The Telomeric Chromosome End (Gallus gallus)
REACT:R-CEL-8944220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIII (Caenorhabditis elegans)
REACT:R-DRE-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Danio rerio)
RHEA:60942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:39507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)
RHEA:15805	skos:prefLabel	"dethiobiotin synthase"
RHEA:15805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dethiobiotin synthase"
RHEA:15805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate
RHEA:15805	skos:altLabel	"DTB synthetase"
REACT:R-SSC-1253343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds ERBB4s80 (Sus scrofa)
RHEA:23188	skos:altLabel	"1,3-propanediol oxidoreductase"
RHEA:23188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADH
RHEA:23188	skos:prefLabel	"1,3-propanediol dehydrogenase"
RHEA:23188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,3-propanediol dehydrogenase"
RHEA:23188	skos:altLabel	"3-hydroxypropionaldehyde reductase"
GO:0047622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ANase activity
GO:0047622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-ribosyladenine ribohydrolase activity
GO:0047622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosinase activity
GO:0047622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine hydrolase activity
GO:0047622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine nucleosidase activity
GO:0047622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine ribohydrolase activity
REACT:R-RNO-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Rattus norvegicus)
REACT:R-HSA-6798044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTG2 binds CCR4-NOT complex (Homo sapiens)
RHEA:53135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-Delta(4)-steroid <=> a 3-oxo-Delta(1,4)-steroid + AH2
REACT:R-SSC-391152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds PTK2B (Sus scrofa)
REACT:R-HSA-4686998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MPDU1 does not promote transfer of Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 by ALG12 (Homo sapiens)
REACT:R-RNO-349637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spherical HDL and SR-BI receptor form a complex at the cell surface (Rattus norvegicus)
RHEA:63038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + octadecanoate => H2O + octadecanamide
REACT:R-GGA-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Gallus gallus)
GO:0106228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]
GO:0106228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide glutaryltransferase activity
REACT:R-BTA-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Bos taurus)
REACT:R-HSA-8932020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPAM gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)
REACT:R-DDI-71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Dictyostelium discoideum)
REACT:R-BTA-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Bos taurus)
RHEA:12132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate
REACT:R-SCE-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Saccharomyces cerevisiae)
REACT:R-HSA-429529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin binding to GP1b:IX:V (Homo sapiens)
REACT:R-CFA-2213195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of anchoring fibrils (Canis familiaris)
RHEA:65413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP(in) + NAD(+)(out) => dAMP(out) + NAD(+)(in)
RHEA:59100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diglucosyl-enterobactin + UDP-alpha-D-glucose = H(+) + triglucosyl-enterobactin + UDP
RHEA:54999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RHEA:28388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
REACT:R-DME-5654672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR1 (Drosophila melanogaster)
EC:1.16.98.-	skos:prefLabel	"With other known acceptors"
EC:1.16.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other known acceptors"
REACT:R-DDI-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Dictyostelium discoideum)
REACT:R-GGA-5357860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Gallus gallus)
RHEA:59328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,5-lactone + H2O = D-xylonate + H(+)
RHEA:59328	skos:prefLabel	"xylono-1,5-lactonase"
RHEA:59328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylono-1,5-lactonase"
RHEA:59328	skos:altLabel	"D-xylono-1,5-lactone lactonase"
REACT:R-SSC-8858369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVRL1 binds BMP9,BMP10 (Sus scrofa)
REACT:R-HSA-4396379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 Coactivator Complex binds HES5 promoter (Homo sapiens)
REACT:R-DRE-5666197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds LIN7B (Danio rerio)
RHEA:22541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-dehydroadenosine + H2O + O2 => 9-riburonosyladenine + H(+) + H2O2
RHEA:59208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + octadecanoate = diphosphate + octadecanoyl-AMP
REACT:R-GGA-5607726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Gallus gallus)
GO:0140413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc:bicarbonate:selenite symporter activity
REACT:R-CEL-6797961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHDH oxidises Cho to BETALD (Caenorhabditis elegans)
RHEA:31127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-methylgallate + O2 = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol
REACT:R-RNO-6799196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Rattus norvegicus)
RHEA:21823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + S-adenosyl-L-methionine <=> H(+) + L-methionine + S-adenosyl-L-homocysteine
REACT:R-MMU-5654607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PPTN11 (Mus musculus)
RHEA:17474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O => 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)
RHEA:10179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH
RHEA:43152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine
RHEA:43152	skos:altLabel	"tRNA (m(1)A(58)) methyltransferase"
RHEA:43152	skos:altLabel	"tRNA m(1)A(58) methyltransferase"
RHEA:43152	skos:prefLabel	"tRNA (adenine(58)-N(1))-methyltransferase"
RHEA:43152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (adenine(58)-N(1))-methyltransferase"
RHEA:54720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-CEL-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Caenorhabditis elegans)
REACT:R-SSC-5686073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-3Y-SHC1 (Sus scrofa)
RHEA:66254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + IC-asc-C7-CoA => ATP + CoA + IC-asc-C7
RHEA:41243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine = N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine
GO:0031841	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neuropeptide Y receptor ligand
GO:0031841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPY receptor binding
GO:0031841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuropeptide Y receptor binding
RHEA:32059	skos:prefLabel	"glucosylglycerate hydrolase"
RHEA:32059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosylglycerate hydrolase"
RHEA:32059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O = (R)-glycerate + D-glucose
RHEA:52499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA
RHEA:37146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:23331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 9-cis-epoxycarotenoid + O2 <=> 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal
RHEA:59157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]
REACT:R-DRE-2247511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2:ligand is endocytosed (Danio rerio)
REACT:R-RNO-109343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Rattus norvegicus)
REACT:R-XTR-8862700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMKLR1 binds Resolvin E1 (Xenopus tropicalis)
RHEA:41534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2
REACT:R-HSA-8852298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Homo sapiens)
REACT:R-GGA-1592240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NRF2 (Gallus gallus)
RHEA:64298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+) => (4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH
REACT:R-BTA-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Bos taurus)
GO:0043842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-manno-octulosonic-acid transferase activity
GO:0043842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kdo transferase activity
GO:0043842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kdtA
GO:0043842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	WaaA
REACT:R-SPO-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Schizosaccharomyces pombe)
RHEA:64293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH => (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)
RHEA:64594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base
RHEA:57481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydodecanoate + H2O2 => 2,3-dihydroxydodecanoate + H2O
RHEA:15159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + homogentisate + NADP(+) => 4-hydroxyphenylacetate + H(+) + NADPH + O2
RHEA:66731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate
REACT:R-HSA-418845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of caspase-3 (Homo sapiens)
REACT:R-HSA-3697838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transfers Cu from ATOX1 to SOD3 (Homo sapiens)
REACT:R-MMU-9632906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ recruits RAS in response to estrogen stimulation (Mus musculus)
REACT:R-XTR-389826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NADPH + H+ => glycolate + NADP+ (Xenopus tropicalis)
GO:0032942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol tetrakisphosphate 2-kinase activity
GO:0032942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-tetrakisphosphate 2-kinase activity
GO:0032942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol-tetrakisphosphate 2-kinase activity
GO:0032942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,3,4,6-tetrakisphosphate 2-kinase activity
REACT:R-HSA-2029988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of overexpressed FGFR2 (Homo sapiens)
REACT:R-BTA-4420099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHB  (Bos taurus)
RHEA:61053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-SPO-2172678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates histone H4K20me1 (Schizosaccharomyces pombe)
RHEA:58957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotide in RNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SPO-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Schizosaccharomyces pombe)
RHEA:71338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-tryptophan(out) + 2 Na(+)(out) <=> chloride(in) + L-tryptophan(in) + 2 Na(+)(in)
REACT:R-HSA-2466392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)
REACT:R-DRE-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Danio rerio)
RHEA:61835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sitosterol + UDP-alpha-D-glucose <=> H(+) + sitosteryl 3-beta-D-glucoside + UDP
REACT:R-SSC-532603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin mediated activation of N-WASP (Sus scrofa)
REACT:R-HSA-109341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Homo sapiens)
RHEA:66171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-with a C-terminal TM segment(out) + ATP + H2O <=> [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate
REACT:R-SSC-354149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta3 with Fibrinogen (Sus scrofa)
RHEA:67846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate
REACT:R-CEL-3322009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Caenorhabditis elegans)
REACT:R-CEL-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Caenorhabditis elegans)
GO:0031634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	replication fork barrier binding
GO:0050526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(3-hydroxybutyrate) depolymerase activity
GO:0050526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(3HB) depolymerase activity
GO:0050526	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	poly((R)-hydroxyalkanoic acid) depolymerase activity
GO:0050526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(HASCL) depolymerase activity
GO:0050526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(HA(SCL)) depolymerase activity
GO:0050526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(HA) depolymerase activity
GO:0050526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PHB depolymerase activity
GO:0050526	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	poly[(R)-hydroxyalkanoic acid] depolymerase
GO:0050526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly[(R)-3-hydroxybutyrate] hydrolase activity
REACT:R-SSC-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Sus scrofa)
RHEA:49242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out)
REACT:R-BTA-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Bos taurus)
RHEA:10759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + phosphate + pyruvate <=> AMP + diphosphate + H(+) + phosphoenolpyruvate
REACT:R-DRE-9708525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1:FBXL17 binds SCF(SKP2) complex (Danio rerio)
REACT:R-HSA-9691363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp12 binds nsp7 and nsp8 (Homo sapiens)
GO:0050074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate-CoA ligase activity
GO:0050074	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate thiokinase activity
GO:0050074	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate:CoA ligase (ADP-forming)
GO:0050074	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malyl-CoA synthetase activity
GO:0050074	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malyl coenzyme A synthetase activity
RHEA:18447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => H2O + IMP
RHEA:56008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
RHEA:27834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + succinate = a menaquinol + fumarate
REACT:R-BTA-180038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Bos taurus)
REACT:R-CFA-5696119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)
RHEA:71444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-methyl-L-dopa(out) + L-phenylalanine(in) => 3-O-methyl-L-dopa(in) + L-phenylalanine(out)
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TyrAT activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tyrosine-2-ketoglutarate aminotransferase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine-alpha-ketoglutarate transaminase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine transaminase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic phenylpyruvic aminotransferase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tyrosine-alpha-ketoglutarate transaminase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylpyruvate transaminase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-tyrosine aminotransferase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylpyruvic acid transaminase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine 2-oxoglutarate aminotransferase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tyrosine transaminase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tyrosine-alpha-ketoglutarate aminotransferase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tyrosine aminotransferase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic-hydroxyphenylpyruvic transaminase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine aminotransferase activity
GO:0004838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine:2-oxoglutarate aminotransferase activity
REACT:R-RNO-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Rattus norvegicus)
RHEA:25804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine
RHEA:35664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)
REACT:R-RNO-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Rattus norvegicus)
RHEA:24937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formimidoylglycine => H2O + imidazol-4-one
REACT:R-HSA-2691211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 HD domain mutants bind DLL4 (Homo sapiens)
REACT:R-MMU-388596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanocortin receptors bind melanocortins (Mus musculus)
REACT:R-RNO-5695957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Rattus norvegicus)
REACT:R-RNO-177157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Rattus norvegicus)
REACT:R-SSC-5672027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Sus scrofa)
REACT:R-DRE-8854052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the SCF-FBXL7 complex (Danio rerio)
RHEA:33017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+) => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2
REACT:R-CFA-8985153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OASL binds DDX58 (Canis familiaris)
REACT:R-SSC-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Sus scrofa)
REACT:R-SSC-8953418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 complex binds E2F6.com-1 core (Sus scrofa)
RHEA:10690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + streptomycin => H2O + streptomycin 6-phosphate
EC:1.14.13.n6	skos:prefLabel	"hexahomomethionine N-hydroxylase"
EC:1.14.13.n6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hexahomomethionine N-hydroxylase"
REACT:R-MMU-73632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Mus musculus)
REACT:R-XTR-70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)
RHEA:11739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-exo-hydroxy-1,8-cineole + NAD(+) <=> 6-oxocineole + H(+) + NADH
RHEA:72491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + maleate(in) = citrate(in) + maleate(out)
RHEA:24976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]
REACT:R-DRE-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Danio rerio)
RHEA:50575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonic acid 5-lipoxygenase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonic 5-lipoxygenase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5Delta-lipoxygenase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leukotriene-A(4) synthase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(5)-lipoxygenase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	LTA synthase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-delta-lipoxygenase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonate:oxygen 5-oxidoreductase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-lipoxygenase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C-5-lipoxygenase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene-A4 synthase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonate 5-lipoxygenase activity
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	leukotriene A4 synthase
GO:0004051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta5-lipoxygenase activity
REACT:R-CFA-1170539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor is internalized (Canis familiaris)
REACT:R-RNO-201790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 is dephosphorylated on Thr75 by PP2A (Rattus norvegicus)
GO:0047991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylamine oxidase activity
GO:0047991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylamine:oxygen oxidoreductase activity
GO:0047991	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxylamine oxidoreductase
GO:0047991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HAO
REACT:R-DRE-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Danio rerio)
REACT:R-SSC-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Sus scrofa)
RHEA:38928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-DRE-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Danio rerio)
RHEA:23632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH
RHEA:16368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digallate + H2O <=> 2 3,4,5-trihydroxybenzoate + H(+)
GO:0044730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bone sialoprotein II binding
GO:0044730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bone sialoprotein binding
REACT:R-HSA-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)
REACT:R-HSA-1791083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Sec12 (Homo sapiens)
RHEA:17090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate
RHEA:62872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 = H2O + NADP(+) + semiviriditoxin
REACT:R-HSA-8950387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX binds EBI3 (Homo sapiens)
RHEA:27869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + alpha-D-mannose 6-phosphate
RHEA:42671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnofuranose + NADP(+) <=> H(+) + L-rhamnono-1,4-lactone + NADPH
REACT:R-HSA-3215251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53INP1 and HIPK2 bind TP53 (Homo sapiens)
RHEA:24809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O
REACT:R-DRE-4085296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NCOA1 with SUMO1 (Danio rerio)
RHEA:30644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + S-methyl-5'-thioinosine => hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
REACT:R-MMU-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Mus musculus)
REACT:R-XTR-975902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)
REACT:R-SSC-4084984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Sus scrofa)
REACT:R-HSA-6783177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates GATA3,IL33 (Homo sapiens)
REACT:R-MMU-432195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Mus musculus)
REACT:R-MMU-72127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal B Complex (Mus musculus)
RHEA:35440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine => archaetidylserine + CMP + H(+)
RHEA:39051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate
REACT:R-CFA-9645535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 phosphorylates TIFA (Canis familiaris)
REACT:R-PFA-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Plasmodium falciparum)
REACT:R-HSA-6786239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)
RHEA:27341	skos:prefLabel	"ammonia monooxygenase"
RHEA:27341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ammonia monooxygenase"
RHEA:27341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + NH4(+) + O2 = A + H(+) + H2O + hydroxylamine
RHEA:27341	skos:altLabel	"AMO"
RHEA:16993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] = 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]
RHEA:16993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-disulfanyl-L-cysteine oxidoreductase"
RHEA:16993	skos:altLabel	"sulfur dehydrogenase"
RHEA:16993	skos:prefLabel	"S-disulfanyl-L-cysteine oxidoreductase"
GO:0102126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coniferyl aldehyde 5-hydroxylase activity
REACT:R-HSA-9640114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins translocate from cilium to cytosol (Homo sapiens)
REACT:R-HSA-927830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
REACT:R-CFA-3215426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Canis familiaris)
RHEA:57235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GDP
RHEA:21236	skos:altLabel	"anthranilate 2,3-hydroxylase (deaminating)"
RHEA:21236	skos:altLabel	"anthranilate hydroxylase"
RHEA:21236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 2 H(+) + NADPH + O2 = 2,3-dihydroxybenzoate + NADP(+) + NH4(+)
RHEA:21236	skos:prefLabel	"anthranilate 3-monooxygenase (deaminating)"
RHEA:21236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthranilate 3-monooxygenase (deaminating)"
RHEA:42369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]
RHEA:45690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in)
RHEA:26240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + diphosphate
GO:0008123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP7A1
GO:0008123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol 7-alpha-hydroxylase activity
GO:0008123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
GO:0008123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol 7alpha-monooxygenase activity
GO:0008123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol 7alpha-hydroxylase activity
GO:0008123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol 7-alpha-monooxygenase activity
GO:0140311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein sequestering activity
REACT:R-HSA-6786257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCTPP1 hydrolyses 5idCTP (Homo sapiens)
REACT:R-HSA-193719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Homo sapiens)
REACT:R-SPO-9626832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)
RHEA:39755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:48526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GQ1c + N-acetylneuraminate => ganglioside GP1c + H2O
RHEA:41010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin <=> 6-linalyl-2-O,3-dimethylflaviolin + diphosphate
REACT:R-HSA-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Homo sapiens)
REACT:R-RNO-198955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR complex interacts with peptide antigen-presenting MHC Class I (Rattus norvegicus)
REACT:R-BTA-110232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by MBD4 glycosylase (Bos taurus)
RHEA:61674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-cysteinyl-5'-AMP => ATP + H(+) + L-cysteine
RHEA:51234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin D2 => 2-glyceryl-prostaglandin H2
REACT:R-RNO-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)
RHEA:54814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + ATP + L-isoleucine
REACT:R-HSA-1632843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1 binds DYNLL1,DYNLL2 (Homo sapiens)
REACT:R-CEL-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Caenorhabditis elegans)
RHEA:15945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] = H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]
REACT:R-MMU-8862771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G2A binds bacterial phospholipids (Mus musculus)
RHEA:57430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol => anisole + O2 + reduced [NADH--hemoprotein reductase]
REACT:R-HSA-5696220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to arsenite(3-) (Homo sapiens)
RHEA:50241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[hyaluronan](n) => n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O
RHEA:48466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 + N-acetylneuraminate => ganglioside GM1b + H2O
RHEA:71789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + CO2 => 2-oxoadipate + O2
RHEA:34522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine <=> [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP
REACT:R-HSA-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Homo sapiens)
RHEA:56245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]
RHEA:55906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,7-dichloro-L-tryptophan + FAD + 2 H2O => 7-chloro-L-tryptophan + chloride + FADH2 + O2
REACT:R-MMU-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Mus musculus)
REACT:R-HSA-9033530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves HSD17B4 (Homo sapiens)
RHEA:36988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + phosphate => alpha-D-ribose 1,5-bisphosphate + cytosine
RHEA:67280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione
RHEA:69823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-211881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A13 (Mus musculus)
REACT:R-MMU-76386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 S-demethylates 6MMP (Mus musculus)
REACT:R-CFA-9667952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 is deacetylated by SIRT2 (Canis familiaris)
RHEA:48530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate => ganglioside GP1c (d18:1(4E)) + H2O
REACT:R-GGA-388830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds ICOS (Gallus gallus)
RHEA:69743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-benzylsuccinate + succinyl-CoA = (S)-2-benzylsuccinyl-CoA + succinate
RHEA:52672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate
REACT:R-XTR-2404199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:IGF1R autophosphorylates (Xenopus tropicalis)
RHEA:61531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base <=> a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base
RHEA:39579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA = (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O
REACT:R-DME-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Drosophila melanogaster)
GO:0047831	skos:prefLabel	"D-ornithine 4,5-aminomutase"
GO:0047831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ornithine aminomutase activity
GO:0047831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alpha-ornithine 5,4-aminomutase activity
GO:0047831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ornithine = (2R,4S)-2,4-diaminopentanoate
GO:0047831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-ornithine 4,5-aminomutase"
GO:0047831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ornithine 4,5-aminomutase activity
GO:0047831	skos:altLabel	"D-ornithine aminomutase"
GO:0047831	skos:altLabel	"D-alpha-ornithine 5,4-aminomutase"
RHEA:51017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-phosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate
REACT:R-CEL-5638007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 activates the GTPase activity of ARL3 (Caenorhabditis elegans)
RHEA:12320	skos:prefLabel	"1,2-dihydrovomilenine reductase"
RHEA:12320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,2-dihydrovomilenine reductase"
RHEA:12320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + 2 H(+) + NADPH
REACT:R-RNO-211178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO1A is excluded from the nucleus (Rattus norvegicus)
REACT:R-GGA-571324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)
RHEA:49021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide
RHEA:16741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA
RHEA:45054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-(2E)-butenoyl-(R)-carnitine => (2E)-butenoyl-CoA + (R)-carnitine
REACT:R-HSA-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Homo sapiens)
RHEA:63971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> atromentin + 2 H2O
REACT:R-BTA-9707594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind LY96 (Bos taurus)
RHEA:69923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	castasterone + O2 + reduced [NADPH--hemoprotein reductase] = brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-BTA-2484965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII binds Integrin alpha1beta1 (Bos taurus)
RHEA:57025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apulose 4-phosphate + D-glyceraldehyde 3-phosphate => D-xylulose 5-phosphate + dihydroxyacetone phosphate
REACT:R-SSC-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)
REACT:R-RNO-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Rattus norvegicus)
REACT:R-HSA-5617485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB2 mRNA is translated (Homo sapiens)
REACT:R-CFA-997326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Canis familiaris)
REACT:R-DRE-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Danio rerio)
REACT:R-HSA-8849646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK5(490-624) binds KLK5 (Homo sapiens)
RHEA:67698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + hexadecanedioate => H2O + hexadecanedioyl-CoA
RHEA:54431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-aspartyl-[protein]
RHEA:53800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholoyl-CoA + ursodeoxycholate = lithocholate + ursodeoxycholoyl-CoA
REACT:R-PFA-8851550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
REACT:R-RNO-8944216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XV (Rattus norvegicus)
RHEA:60679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(-)-citronellol + NAD(+) <=> (S)-(-)-citronellal + H(+) + NADH
RHEA:54480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
RHEA:47718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone + H(+) + NADH => 4-pregnen-20,21-diol-3-one + NAD(+)
REACT:R-DRE-6810239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Danio rerio)
RHEA:36434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine 2'-deoxy-D-ribonucleoside + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase
GO:0099122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain binding
GO:0099122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNAP II C-terminal binding
REACT:R-DRE-9023619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Danio rerio)
GO:0038100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nodal binding
REACT:R-SSC-141046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Sus scrofa)
REACT:R-RNO-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Rattus norvegicus)
RHEA:49943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2
RHEA:49686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + H2O + NAD(+) => H(+) + NADH + O2 + resorcinol
REACT:R-HSA-9678561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Homo sapiens)
REACT:R-SPO-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Schizosaccharomyces pombe)
REACT:R-SSC-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Sus scrofa)
RHEA:64326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (11Z)-octadecenoate + CoA => (11Z)-octadecenoyl-CoA + cholesterol
REACT:R-SSC-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Sus scrofa)
REACT:R-HSA-2895778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)
RHEA:46586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:13845	skos:prefLabel	"dihydroxyfumarate decarboxylase"
RHEA:13845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO2
RHEA:13845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroxyfumarate decarboxylase"
RHEA:13845	skos:altLabel	"dihydroxyfumarate carboxy-lyase"
REACT:R-HSA-6787677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUOM isomerises alpha-Fuc to beta-Fuc (Homo sapiens)
REACT:R-CEL-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Caenorhabditis elegans)
REACT:R-XTR-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Xenopus tropicalis)
RHEA:69607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-[tubulin] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]
RHEA:39429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH
RHEA:30876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + D-glutamate
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP:D-mannose-1-phosphate guanylyltransferase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP:mannose-1-phosphate guanylyltransferase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannose 1-phosphate guanylyltransferase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP mannose phosphorylase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose phosphorylase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose pyrophosphorylase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose 1-phosphate guanylyltransferase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose phosphorylase activity
GO:0008928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose-1-phosphate guanylyltransferase (GDP) activity
REACT:R-BTA-430190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds NCK (Bos taurus)
REACT:R-GGA-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Gallus gallus)
RHEA:40099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-BTA-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Bos taurus)
REACT:R-CEL-9624120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK2 (Caenorhabditis elegans)
REACT:R-MMU-2168881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Truncated Alpha-1-Microglobulin binds heme (Mus musculus)
REACT:R-GGA-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Gallus gallus)
GO:0070403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD binding
GO:0070403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ binding
GO:0070403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD (oxidized) binding
GO:0070403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized NAD binding
GO:0070403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized nicotinamide adenine dinucleotide binding
RHEA:30014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-galactose(out) + H2O <=> ADP + beta-D-galactose(in) + H(+) + phosphate
REACT:R-BTA-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Bos taurus)
RHEA:38430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate
REACT:R-GGA-391378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follicle-stimulating hormone receptor can bind FSH (Gallus gallus)
RHEA:59808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine = D-tyrosine
REACT:R-DDI-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Dictyostelium discoideum)
RHEA:10280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + H(+) + S-adenosyl-L-homocysteine
RHEA:16890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 6-acetamido-3-aminohexanoate => 6-acetamido-3-oxohexanoate + L-glutamate
RHEA:48799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate oxidase activity
GO:0050031	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-pipecolic acid oxidase activity
GO:0050031	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-pipecolate:oxygen 1,6-oxidoreductase activity
REACT:R-MMU-879934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)
RHEA:53545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-SSC-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Sus scrofa)
REACT:R-SSC-9669893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type I TKIs (Sus scrofa)
REACT:R-BTA-352052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Bos taurus)
REACT:R-SSC-990489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-13 is a dimer (Sus scrofa)
RHEA:69595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + inosine <=> cytidine + IMP
GO:0016994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	precorrin-6Y:NADP(+) oxidoreductase activity
GO:0016994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	precorrin-6Y:NADP+ oxidoreductase activity
GO:0016994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	precorrin-6B:NADP+ oxidoreductase activity
GO:0016994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6X reductase activity
GO:0016994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6A reductase activity
REACT:R-CEL-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Caenorhabditis elegans)
REACT:R-MMU-374663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Ezrin (Mus musculus)
REACT:R-MMU-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Mus musculus)
REACT:R-SSC-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Sus scrofa)
RHEA:18501	skos:prefLabel	"Delta(24(24(1)))-sterol reductase"
RHEA:18501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Delta(24(24(1)))-sterol reductase"
RHEA:18501	skos:altLabel	"C-24(28) sterol reductase"
RHEA:18501	skos:altLabel	"sterol Delta(24(28))-methylene reductase"
RHEA:18501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH
RHEA:18501	skos:altLabel	"sterol Delta(24(28))-reductase"
RHEA:39325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH
REACT:R-SSC-5423637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR dimers reduce AFBDHO to AFBDOH (Sus scrofa)
RHEA:42427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylmaleate + H2O <=> (2R,3S)-3-methylmalate
REACT:R-DDI-2162225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from small HA fragments (Dictyostelium discoideum)
REACT:R-XTR-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Xenopus tropicalis)
GO:0001095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIE-class transcription factor complex binding
GO:0001095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIE-class transcription factor binding
REACT:R-HSA-9674015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Olaratumab binds PDGFRA (Homo sapiens)
REACT:R-DDI-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Dictyostelium discoideum)
RHEA:11279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 hydroquinone + O2 <=> 4 benzosemiquinone + 2 H2O
REACT:R-CEL-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Caenorhabditis elegans)
RHEA:56332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenosine + H2O = AMP + ATP + H(+)
GO:0098638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laminin binding involved in cell-matrix adhesion
EC:3.2.2.27	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uracil-DNA glycosylase"
EC:3.2.2.27	skos:altLabel	"uracil-DNA N-glycosylase"
EC:3.2.2.27	skos:altLabel	"uracil DNA glycohydrolase"
EC:3.2.2.27	skos:prefLabel	"uracil-DNA glycosylase"
REACT:R-DRE-8862152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Danio rerio)
REACT:R-DME-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Drosophila melanogaster)
REACT:R-MMU-4084994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU3 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)
GO:0004372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity
GO:0004372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine hydroxymethyltransferase activity
GO:0004372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine hydroxymethylase activity
GO:0004372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine hydroxymethyltransferase activity
GO:0004372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	allothreonine aldolase activity
GO:0004372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine transhydroxymethylase activity
GO:0004372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine hydroxymethyltransferase activity
GO:0004372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine aldolase activity
REACT:R-HSA-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Homo sapiens)
REACT:R-SSC-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Sus scrofa)
REACT:R-RNO-265428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with VCAM1 (Rattus norvegicus)
REACT:R-CFA-8864036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates PDGFRB at Y1021 (Canis familiaris)
REACT:R-SCE-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Saccharomyces cerevisiae)
RHEA:59719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaono-1,5-lactone + H2O <=> D-maltopentaonate + H(+)
REACT:R-CFA-211968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2W1 oxidises INDOL (Canis familiaris)
RHEA:36869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:61261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamine + O2 => 2-oxoglutaramate + H2O2 + NH4(+)
REACT:R-CFA-2161890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)
REACT:R-MMU-9702354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCA antibodies (Mus musculus)
REACT:R-HSA-9659515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell (Homo sapiens)
REACT:R-HSA-140851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Homo sapiens)
REACT:R-SSC-8863101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPPL2a/b cleaves TNF(1-76) (Sus scrofa)
REACT:R-CEL-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Caenorhabditis elegans)
REACT:R-MMU-158357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIIa binds SERPING1 (Mus musculus)
RHEA:37185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate
GO:0034417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisphosphoglycerate 3-phosphatase activity
GO:0034417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-bisphospho-D-glycerate 3-phosphohydrolase activity
RHEA:27528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-SSC-9714363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC translocates to the endoplasmic reticulum membrane (Sus scrofa)
REACT:R-DRE-433711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-homodimerization of nectins (Danio rerio)
RHEA:14666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine + H(+) + H2O => NH4(+) + xanthine
EC:1.13.11.26	skos:altLabel	"pyrrolooxygenase"
EC:1.13.11.26	skos:altLabel	"tryptophan pyrrolooxygenase"
EC:1.13.11.26	skos:prefLabel	"peptide-tryptophan 2,3-dioxygenase"
EC:1.13.11.26	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptide-tryptophan 2,3-dioxygenase"
RHEA:70840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-histidine(out) + Na(+)(out) => L-arginine(out) + L-histidine(in) + Na(+)(in)
RHEA:47166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADH + zymosterone => 4alpha-carboxyzymosterol + NAD(+)
RHEA:25461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + sibirene
GO:0140713	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleosome remodeling activity
GO:0140713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone chaperone activity
GO:0140713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone carrier activity
REACT:R-BTA-964759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alternative endo-mannosidase I route (Bos taurus)
RHEA:16339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:32958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate
RHEA:34782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH
RHEA:41916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]
EC:3.6.1.24	skos:prefLabel	"nucleoside phosphoacylhydrolase"
EC:3.6.1.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside phosphoacylhydrolase"
RHEA:62230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + patulin => (E)-ascladiol + A
REACT:R-XTR-159574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Xenopus tropicalis)
REACT:R-CEL-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Caenorhabditis elegans)
REACT:R-RNO-8948234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB:4-Hyp collagen propeptides dissociates (Rattus norvegicus)
RHEA:47253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> cubebol + diphosphate
RHEA:22935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:63165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tricosanoyl-taurine => taurine + tricosanoate
REACT:R-HSA-418451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP stimulates Protein Kinase G (Homo sapiens)
REACT:R-DRE-8942302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP13 cleaves OPTC (Danio rerio)
RHEA:28793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + thymine => 5,6-dihydrothymine + NAD(+)
GO:0018554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxynaphthalene dioxygenase activity
REACT:R-RNO-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Rattus norvegicus)
RHEA:20329	skos:altLabel	"LDL receptor kinase"
RHEA:20329	skos:altLabel	"low-density lipoprotein receptor kinase"
RHEA:20329	skos:altLabel	"low-density-lipoprotein receptor kinase (phosphorylating)"
RHEA:20329	skos:altLabel	"low-density-lipoprotein kinase"
RHEA:20329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[low-density-lipoprotein receptor] = ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]
RHEA:20329	skos:prefLabel	"[low-density-lipoprotein receptor] kinase"
RHEA:20329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[low-density-lipoprotein receptor] kinase"
RHEA:67197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylserotonin => acetate + serotonin
REACT:R-MMU-8950537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Mus musculus)
REACT:R-GGA-4615839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO2,3 (Gallus gallus)
RHEA:37743	skos:prefLabel	"flavin prenyltransferase"
RHEA:37743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavin prenyltransferase"
RHEA:37743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2
REACT:R-MMU-549297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-GGA-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Gallus gallus)
REACT:R-MMU-8852200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of LCK by PTPN22 (Mus musculus)
REACT:R-XTR-141422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 converted  to an inhibitory state via interaction with Mad1 (Xenopus tropicalis)
RHEA:50146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + ethanol + H(+) => ethyl (9Z)-hexadecenoate + H2O
RHEA:20791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + phosphate <=> ADP-beta-D-ribose 1''-phosphate + H(+) + nicotinamide
REACT:R-SSC-382052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)
REACT:R-CEL-196402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Caenorhabditis elegans)
REACT:R-CFA-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Canis familiaris)
REACT:R-HSA-2972977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter (Homo sapiens)
REACT:R-DRE-3371360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Danio rerio)
RHEA:24987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:25106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + pyridoxamine 5'-phosphate => ATP + pyridoxamine
REACT:R-BTA-9638120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU4 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)
REACT:R-HSA-2467761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A2E is phagocytosed (Homo sapiens)
REACT:R-HSA-9631068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8:substrate binds late endosomal phospholipids (Homo sapiens)
REACT:R-RNO-380311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Plk1 to centrosomes (Rattus norvegicus)
REACT:R-HSA-9623072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMC gene expression is inhibited by FOXO1 (Homo sapiens)
REACT:R-SCE-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Saccharomyces cerevisiae)
RHEA:45784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + phenylpropanonitrile = 3-phenylpropanoate + NH4(+)
REACT:R-DRE-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Danio rerio)
REACT:R-RNO-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Rattus norvegicus)
RHEA:48242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GT1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b
REACT:R-RNO-445813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Smooth Muscle Myosin Light Chains (Rattus norvegicus)
RHEA:42076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + acetyl-CoA = 2-hydroxyglutaryl-CoA + acetate
RHEA:64183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-tryptophan + H2O <=> a fatty acid + L-tryptophan
REACT:R-XTR-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Xenopus tropicalis)
RHEA:36332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate
GO:0019104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA glycosylase activity
GO:0019104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endonuclease VIII activity
GO:0019104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA N-glycosylase activity
REACT:R-DME-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Drosophila melanogaster)
REACT:R-GGA-996755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFPM proteins bind GATA proteins (Gallus gallus)
RHEA:67733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridylyl-uridylyl-ribonucleotide-RNA => a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA
REACT:R-DRE-158800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Danio rerio)
REACT:R-RNO-9678561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Rattus norvegicus)
REACT:R-XTR-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Xenopus tropicalis)
RHEA:65347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA <=> (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-CEL-4754181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me2K5-histone H3 (Caenorhabditis elegans)
RHEA:34232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-nitrosalicylate + O2 => 4-nitro-6-oxohepta-2,4-dienedioate + H(+)
REACT:R-SSC-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)
REACT:R-DRE-73596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => dUMP + NH4+ (Danio rerio)
GO:0005125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	autocrine activity
GO:0005125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokine activity
GO:0005125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	paracrine activity
REACT:R-SSC-8848776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates DOK1 (Sus scrofa)
GO:0008114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphogluconate dehydrogenase activity
GO:0008114	skos:altLabel	"6-phosphogluconic dehydrogenase"
GO:0008114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphogluconate 2-dehydrogenase"
GO:0008114	skos:altLabel	"6-phosphogluconate 2-dehydrogenase"
GO:0008114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity
GO:0008114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphogluconate dehydrogenase (NAD)
GO:0008114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphogluconate 2-dehydrogenase activity
GO:0008114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-6-phosphogluconate reductase activity
GO:0008114	skos:prefLabel	"phosphogluconate 2-dehydrogenase"
GO:0008114	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	6-phosphogluconic dehydrogenase activity
GO:0008114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phosphogluconate 2-dehydrogenase activity
GO:0008114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gluconate 6-phosphate dehydrogenase activity
REACT:R-HSA-9008389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds HDAC6 (Homo sapiens)
REACT:R-DME-450466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1:mRNA complex is destroyed (Drosophila melanogaster)
RHEA:46831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH
REACT:R-SSC-8983878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Sus scrofa)
RHEA:36945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA
RHEA:51224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]
RHEA:28840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Zn(2+)(in) => H(+)(in) + Zn(2+)(out)
RHEA:54509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate => beta-heptaprene + diphosphate
RHEA:30493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => L-valine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Gallus gallus)
REACT:R-CFA-354066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PTK2 to Focal complexes (Canis familiaris)
REACT:R-MMU-9610154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated MAP2Ks and MAPKs (Mus musculus)
RHEA:13848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyfumarate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2
RHEA:31866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> friedelin
RHEA:60526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine
GO:0004651	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide 5'-triphosphatase activity
GO:0004651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polynucleotide 5'-phosphatase activity
GO:0004651	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide 5'-phosphohydrolase activity
GO:0004651	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-polynucleotidase activity
REACT:R-BTA-8848247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD4,5 bind MCFA-CoA and LCFA-CoA (Bos taurus)
REACT:R-XTR-174171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A with the APC/C (Xenopus tropicalis)
REACT:R-DRE-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)
REACT:R-BTA-8869456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)
REACT:R-SSC-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Sus scrofa)
RHEA:12289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucoside + H2O => an alcohol + L-fucose
RHEA:49095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphate
REACT:R-MMU-5368580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Mus musculus)
RHEA:50164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-4551661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates RNF168 with SUMO1 (Xenopus tropicalis)
REACT:R-BTA-914182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)
REACT:R-PFA-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Plasmodium falciparum)
RHEA:23905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] => 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]
REACT:R-DME-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Drosophila melanogaster)
REACT:R-DRE-2162002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Danio rerio)
REACT:R-SSC-8849908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM4 binds flotillin-1 (Sus scrofa)
RHEA:51188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide + superoxide = peroxynitrite
GO:0034936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity
RHEA:39787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+) => (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O
REACT:R-SSC-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Sus scrofa)
REACT:R-BTA-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
RHEA:14235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA
RHEA:27621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate <=> di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate
REACT:R-SSC-9011981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 is recruited to MYC and BCL2 genes (Sus scrofa)
RHEA:41492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine
REACT:R-BTA-4754187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Bos taurus)
REACT:R-HSA-73806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIR + CO2 => CAIR (Homo sapiens)
REACT:R-DME-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Drosophila melanogaster)
REACT:R-CFA-5666129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP recruits DIAPH2-2 to kinetochores (Canis familiaris)
REACT:R-SPO-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Schizosaccharomyces pombe)
GO:0046026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-4 C11-methyltransferase activity
GO:0046026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity
GO:0046026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobM
RHEA:70445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2
REACT:R-MMU-6798044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTG2 binds CCR4-NOT complex (Mus musculus)
REACT:R-HSA-9023196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)
REACT:R-SSC-6805103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates TP53 (Sus scrofa)
REACT:R-MMU-2509816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses IDP to IMP (Mus musculus)
RHEA:52928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-GMP + 2 H2O = 2 GMP + 2 H(+)
REACT:R-DRE-8848436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CDKN1B (Danio rerio)
REACT:R-MMU-5684248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
REACT:R-RNO-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Rattus norvegicus)
REACT:R-RNO-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Rattus norvegicus)
REACT:R-MMU-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Mus musculus)
REACT:R-XTR-8938121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds CTSK (Xenopus tropicalis)
REACT:R-SCE-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Saccharomyces cerevisiae)
REACT:R-SSC-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Sus scrofa)
REACT:R-MMU-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Mus musculus)
RHEA:64521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA => A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde
RHEA:18757	skos:prefLabel	"7-deoxycylindrospermopsin hydroxylase"
RHEA:18757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = 7-epi-cylindrospermopsin + CO2 + succinate
RHEA:18757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = CO2 + cylindrospermopsin + succinate
RHEA:18757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-deoxycylindrospermopsin hydroxylase"
RHEA:29554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucose <=> alpha-D-galactose 1-phosphate + 2 H(+) + UMP
REACT:R-DME-2022141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolysyl oxidase activation (Drosophila melanogaster)
REACT:R-GGA-6788999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HV1-mediated H+ transfer (Gallus gallus)
REACT:R-DRE-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Danio rerio)
REACT:R-RNO-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Rattus norvegicus)
REACT:R-CFA-8959462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Canis familiaris)
REACT:R-SCE-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Saccharomyces cerevisiae)
REACT:R-SSC-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Sus scrofa)
RHEA:13414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + thymidine => AMP + dTMP + H(+)
REACT:R-PFA-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Plasmodium falciparum)
GO:0031778	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 melanin-concentrating hormone receptor ligand
GO:0031778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 melanin-concentrating hormone receptor binding
REACT:R-SSC-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Sus scrofa)
REACT:R-DME-390145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated HPO dimer phosphorylates SAV (Drosophila melanogaster)
RHEA:23573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisovalerophenone
RHEA:54592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate
RHEA:40643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-XTR-8847875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF1:GTP binds Golgin TRIP11 (Xenopus tropicalis)
RHEA:23180	skos:prefLabel	"secondary-alcohol oxidase"
RHEA:23180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + O2 = a ketone + H2O2
RHEA:23180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"secondary-alcohol oxidase"
RHEA:40316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + O2 => (2E)-glutaconyl-CoA + H2O2
RHEA:69088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + H2O + NAD(+) = butanoate + 2 H(+) + NADH
REACT:R-RNO-9679775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT binds COMT Inhibitors (Rattus norvegicus)
RHEA:40865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + trans-2-heptadecenoyl-CoA => FAD + H(+) + heptadecanoyl-CoA
RHEA:47685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n) + phosphate => [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
RHEA:11498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(uracil-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + uracil
REACT:R-HSA-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Homo sapiens)
REACT:R-XTR-193101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11A1 cleaves 20a,22b-DHCHOL (Xenopus tropicalis)
RHEA:16343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-diphosphomevalonate + ADP => (R)-5-phosphomevalonate + ATP
RHEA:29723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate(in) = glyoxylate(out)
GO:0015143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A12 exchanges extracellular urate for cytosolic LACT (Homo sapiens)
GO:0015143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urate transmembrane transporter activity
GO:0015143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uric acid transmembrane transporter activity
REACT:R-GGA-917693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESCRT Disassembly (Gallus gallus)
REACT:R-CFA-6788867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3K phosphorylates ketosamines (Canis familiaris)
RHEA:39262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z)-docosenoyl-CoA <=> (2E,13Z)-docosadienoyl-CoA + H2O
RHEA:29844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + propanoate => ADP + phosphate + propanoyl-CoA
REACT:R-CFA-140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS1 (Canis familiaris)
REACT:R-BTA-8853789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDNF,NRTN bind RET:GFRA1,GFRA2 (Bos taurus)
RHEA:67470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine => H2O + malonyl-CoA
REACT:R-GGA-4341072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RARA with SUMO2 (Gallus gallus)
REACT:R-XTR-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Xenopus tropicalis)
REACT:R-BTA-75146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Bos taurus)
RHEA:20282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate => (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)
REACT:R-DRE-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Danio rerio)
REACT:R-HSA-9670416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs by KIT mutants (Homo sapiens)
RHEA:18183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + CoA + H(+) => acetyl-CoA + glyoxylate + H2O
REACT:R-GGA-83790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Gallus gallus)
REACT:R-HSA-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Homo sapiens)
RHEA:50576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]
REACT:R-BTA-5649799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Bos taurus)
RHEA:59541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2
RHEA:34105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:10762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + oxaloacetate => citrate
REACT:R-HSA-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)
REACT:R-SSC-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Sus scrofa)
RHEA:48879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-glucosamine
GO:0046817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine receptor antagonist activity
RHEA:57129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 oxidized [azurin] + tyramine => (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]
REACT:R-RNO-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Rattus norvegicus)
REACT:R-DRE-77274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Danio rerio)
RHEA:24078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(5)-steroid + H(+) + NADH => a 3beta-hydroxy-Delta(5)-steroid + NAD(+)
REACT:R-XTR-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Xenopus tropicalis)
REACT:R-MMU-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Mus musculus)
RHEA:29480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (+)-epicubenol + diphosphate
RHEA:39881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol
RHEA:72361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + succinate(in) => glutarate(in) + succinate(out)
REACT:R-DRE-5693609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53 at S15 (Danio rerio)
RHEA:70703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cycloserine(in) + H(+)(in) = D-cycloserine(out) + H(+)(out)
GO:0031871	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proteinase activated receptor ligand
GO:0031871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteinase activated receptor binding
REACT:R-MMU-389463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteinase-activated receptors can bind thrombin (Mus musculus)
REACT:R-RNO-1168894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A/B dissociates from the Growth Hormone receptor (Rattus norvegicus)
REACT:R-XTR-193763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)
REACT:R-SSC-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Sus scrofa)
RHEA:52194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:38744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol
REACT:R-CEL-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Caenorhabditis elegans)
REACT:R-XTR-1592297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full activation of MMP1 (Xenopus tropicalis)
REACT:R-CFA-388828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PD-1 binds B7DC and B7H1 (Canis familiaris)
REACT:R-RNO-75079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC C complex (Rattus norvegicus)
RHEA:15318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-deoxy-alpha-D-glucoside + H2O => 2-deoxy-D-glucose + an alcohol
REACT:R-SSC-5649664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyG from damaged DNA (Sus scrofa)
REACT:R-GGA-4641249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Gallus gallus)
REACT:R-DRE-4086205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN (osteopontin) degradation by MMP3, MMP7 (Danio rerio)
EC:1.3.1.89	skos:altLabel	"tRNA-dihydrouridine synthase 3"
EC:1.3.1.89	skos:prefLabel	"tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"
EC:1.3.1.89	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"
RHEA:58753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)
REACT:R-HSA-8853322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasma membrane FGFR1 fusions dimerize (Homo sapiens)
GO:0033881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bile-acid-CoA transferase activity
GO:0033881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bile-acid-CoA hydrolase activity
GO:0033881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycholoyl-CoA transferase activity
RHEA:46309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-427528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Sus scrofa)
REACT:R-DRE-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Danio rerio)
REACT:R-CFA-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Canis familiaris)
REACT:R-XTR-114392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Xenopus tropicalis)
REACT:R-DME-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Drosophila melanogaster)
RHEA:12924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H(+) + succinyl-CoA <=> 5-aminolevulinate + CO2 + CoA
REACT:R-DME-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Drosophila melanogaster)
RHEA:59721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaono-1,5-lactone + H2O => D-maltohexaonate + H(+)
RHEA:51122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2
GO:0050065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine-pyruvate aminotransferase activity
GO:0050065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine-pyruvate 6-transaminase activity
GO:0050065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine:pyruvate aminotransferase activity
GO:0050065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Lys-AT
GO:0050065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine--pyruvate 6-aminotransferase activity
RHEA:22918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetoxyphenol + H2O + NADP(+) => 4'-hydroxyacetophenone + H(+) + NADPH + O2
REACT:R-DME-8948775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKRN1 polyubiquitinates PTEN (Drosophila melanogaster)
GO:0004796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity
GO:0004796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thromboxane-A synthase activity
GO:0004796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thromboxane synthetase activity
GO:0004796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity
GO:0004796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thromboxane synthase activity
GO:0004796	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP5
RHEA:50886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-glycerol + phosphate => (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O
GO:0047414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	compound B hydrolase activity
GO:0047414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity
GO:0047414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity
GO:0047414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)
RHEA:25123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-1-piperideine-6-carboxylate => (S)-2-amino-6-oxohexanoate
REACT:R-MMU-982775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor dimerizes (Mus musculus)
REACT:R-HSA-8948651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-106a,(miR106b) microRNA binds CNOT6L mRNA (Homo sapiens)
REACT:R-DRE-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Danio rerio)
RHEA:14087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA
REACT:R-CEL-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)
REACT:R-RNO-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Rattus norvegicus)
RHEA:22021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + molybdate(out) => ADP + H(+) + molybdate(in) + phosphate
RHEA:11477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 1-phosphate + H2O => glycerol + phosphate
REACT:R-GGA-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Gallus gallus)
RHEA:40809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:21426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+)
REACT:R-BTA-193650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR binds to NADE (Bos taurus)
RHEA:66416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O = ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate
REACT:R-MMU-193099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPROG to ANDST (Mus musculus)
RHEA:26527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O
GO:0102592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity
RHEA:18377	skos:altLabel	"streptomycin 3''-phosphotransferase"
RHEA:18377	skos:prefLabel	"streptomycin 3''-kinase"
RHEA:18377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"streptomycin 3''-kinase"
RHEA:18377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin = ADP + H(+) + streptomycin 3''-phosphate
RHEA:10929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dehydroascorbate(in) => L-dehydroascorbate(out)
REACT:R-SPO-75010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser 216 by Chk1 (Schizosaccharomyces pombe)
REACT:R-SSC-2172678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates histone H4K20me1 (Sus scrofa)
RHEA:34139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(9)-tetrahydrocannabinolate + H(+) = CO2 + Delta(9)-tetrahydrocannabinol
RHEA:67343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + quercetin 3-O-beta-D-glucoside <=> CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)
GO:0004735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P5CR activity
GO:0004735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-pyrroline-5-carboxylate reductase activity
GO:0004735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-proline:NAD(P)+ 5-oxidoreductase activity
GO:0004735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-proline oxidase activity
GO:0004735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-L-delta1-pyrroline carboxylic acid reductase activity
GO:0004735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrroline-5-carboxylate reductase activity
GO:0004735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-proline-NAD(P)+ 5-oxidoreductase activity
REACT:R-CFA-6789092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide anion from oxygen (Canis familiaris)
REACT:R-DDI-975147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Dictyostelium discoideum)
REACT:R-RNO-983161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Rattus norvegicus)
RHEA:36337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate + 2 H(+) + NADH => D-glucuronate + H2O + NAD(+)
RHEA:18837	skos:altLabel	"acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase"
RHEA:18837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C
RHEA:18837	skos:prefLabel	"10-hydroxytaxane O-acetyltransferase"
RHEA:18837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"10-hydroxytaxane O-acetyltransferase"
REACT:R-XTR-166245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Xenopus tropicalis)
REACT:R-DDI-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)
REACT:R-GGA-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Gallus gallus)
REACT:R-XTR-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Xenopus tropicalis)
REACT:R-MMU-201595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plakophilin-1 (Mus musculus)
GO:0071820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-box binding
GO:0071820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-box promoter binding
GO:0071820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N box binding
REACT:R-BTA-187895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal C-ter TLR9 (Bos taurus)
GO:2001147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	camalexin binding
GO:2001147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(1,3-thiazol-2-yl)-1H-indole binding
REACT:R-DRE-2395876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)
REACT:R-HSA-1855212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3-PP-IP5 transports from the cytosol to the nucleus (Homo sapiens)
RHEA:33183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) = citrate(out)
REACT:R-CFA-8950342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBI3:CANX binds IL27 (Canis familiaris)
RHEA:38224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + decan-1-ol => 1-O-decyl-(9Z)-octadecenoate + CoA
EC:6.4.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetone carboxylase"
EC:6.4.1.6	skos:prefLabel	"acetone carboxylase"
GO:0047978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanol dehydrogenase activity
GO:0047978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexadecanol:NAD+ oxidoreductase activity
REACT:R-HSA-5693580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
REACT:R-DME-416683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA3E binds to PLXND1 (Drosophila melanogaster)
REACT:R-HSA-9709571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)
REACT:R-RNO-432952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP180 interacts intracellularly with plectin and integrin beta4 (Rattus norvegicus)
RHEA:10403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + pyruvate <=> 2-oxoglutaramate + L-alanine
RHEA:42161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O
RHEA:16619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + D-glucose => beta-D-glucosyl-(1->3)-D-glucose + phosphate
REACT:R-MMU-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Mus musculus)
GO:0102927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-chaconine rhamnosyltransferase activity
RHEA:63326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycerol + ATP
RHEA:52581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Pb(2+)(in) => ADP + H(+) + Pb(2+)(out) + phosphate
REACT:R-DDI-548815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Dictyostelium discoideum)
REACT:R-CFA-190326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 (Canis familiaris)
GO:0042577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid phosphatase activity
REACT:R-RNO-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Rattus norvegicus)
REACT:R-SSC-8937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)
REACT:R-CFA-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Canis familiaris)
REACT:R-XTR-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Xenopus tropicalis)
REACT:R-HSA-6797568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind CASK:Protein 4.1 (Homo sapiens)
REACT:R-BTA-2197698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src phosphorylate WASP,N-WASP (Bos taurus)
RHEA:21660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH
RHEA:21660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzaldehyde dehydrogenase (NADP(+))"
RHEA:21660	skos:prefLabel	"benzaldehyde dehydrogenase (NADP(+))"
GO:0031821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metabotropic 5-hydroxytryptamine receptor binding
GO:0031821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled serotonin receptor binding
GO:0031821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metabotropic serotonin receptor ligand
GO:0031821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled serotonin receptor binding
GO:0031821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metabotropic serotonin receptor binding
REACT:R-MMU-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Mus musculus)
RHEA:20949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfopyruvate + H(+) => CO2 + sulfoacetaldehyde
GO:0030250	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	guanylin
GO:0030250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanylate cyclase activator activity
RHEA:23295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-lombricine <=> ADP + H(+) + N-phospho-L-lombricine
RHEA:61961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:17883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine + sulfate => H2O + N-sulfo-D-glucosamine
REACT:R-SSC-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Sus scrofa)
REACT:R-BTA-5690827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 (Bos taurus)
REACT:R-RNO-917835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from holoTF:TFRC dimer (Rattus norvegicus)
REACT:R-DRE-5654591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)
REACT:R-DME-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Drosophila melanogaster)
REACT:R-GGA-352268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Satb1 (Gallus gallus)
RHEA:20226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + S-adenosyl-L-methionine => (E)-ferulate + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-2993447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6x(PCCA:PCCB) (Bos taurus)
REACT:R-SSC-1676164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Sus scrofa)
RHEA:21425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH
RHEA:10395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamyl alcohol + NADP(+) <=> (E)-cinnamaldehyde + H(+) + NADPH
RHEA:11502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O
RHEA:50012	skos:altLabel	"tert-butyl alcohol monooxygenase"
RHEA:50012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tert-butanol = 2-methylpropane-1,2-diol + H2O + NADP(+)
RHEA:50012	skos:prefLabel	"tert-butanol monooxygenase"
RHEA:50012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tert-butanol monooxygenase"
REACT:R-MMU-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Mus musculus)
REACT:R-HSA-8875013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM3,ACSM6 ligate CoA to BUT (Homo sapiens)
REACT:R-HSA-5368582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXXC4 binds DVL to prevent AXIN binding (Homo sapiens)
REACT:R-HSA-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)
RHEA:45844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-CoA + NADP(+) = 3-oxooctanoyl-CoA + H(+) + NADPH
REACT:R-XTR-6801766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Xenopus tropicalis)
REACT:R-DME-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)
REACT:R-DRE-5357432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL binds SRC-1 (Danio rerio)
RHEA:62057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)
RHEA:45195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-8950456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B dimerizes (Homo sapiens)
REACT:R-BTA-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Bos taurus)
REACT:R-HSA-6803255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCOOH translocated from mitochondrial matrix to cytosol (Homo sapiens)
EC:2.3.1.26	skos:altLabel	"sterol-ester synthase"
EC:2.3.1.26	skos:altLabel	"cholesterol acyltransferase"
EC:2.3.1.26	skos:prefLabel	"sterol O-acyltransferase"
EC:2.3.1.26	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sterol O-acyltransferase"
REACT:R-HSA-1067688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)
REACT:R-DRE-2032775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD1 (Danio rerio)
RHEA:21985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + choline => adenosine 3',5'-bisphosphate + choline sulfate + H(+)
RHEA:12490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate
REACT:R-DME-1358795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitination of RNF41 by P-USP8 (Drosophila melanogaster)
REACT:R-HSA-4755572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SRD5A3 does not reduce pPNOL to DCHOL (Homo sapiens)
REACT:R-GGA-749446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Gallus gallus)
RHEA:48536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)
RHEA:54138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA precursor + S-adenosyl-L-methionine
REACT:R-MMU-190429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c (Mus musculus)
RHEA:11259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + limonin + UDP-alpha-D-glucose <=> glucosyl-limonin + 2 H(+) + UDP
REACT:R-XTR-449073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-3 cleaves pro-interleukin-16 (Xenopus tropicalis)
REACT:R-BTA-74247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Bos taurus)
REACT:R-BTA-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Bos taurus)
REACT:R-HSA-9700179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of ALK fusions (Homo sapiens)
RHEA:41646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA
REACT:R-SPO-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Schizosaccharomyces pombe)
REACT:R-DRE-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Danio rerio)
RHEA:33448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carboxylate + NADP(+) => 3-dehydro-4-methylzymosterol + CO2 + NADPH
REACT:R-SPO-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Schizosaccharomyces pombe)
REACT:R-CFA-9615348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR2 (Canis familiaris)
REACT:R-RNO-380905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serotonin loaded synaptic vesicle docking and priming (Rattus norvegicus)
RHEA:33463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	episterol + H(+) + NADPH + O2 = 5-dehydroepisterol + 2 H2O + NADP(+)
GO:0016891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoribonuclease activity, producing 5'-phosphomonoesters
REACT:R-XTR-9007447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 forms the PRC1L4 complex (Xenopus tropicalis)
RHEA:31983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide B + H(+) + phosphate
RHEA:57506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + succinate => 3-hydroxybutane-1,2,3-tricarboxylate
RHEA:50341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone => 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:69490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + tetradecanal => O2 + tetradecan-1-ol
REACT:R-BTA-8873946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD3 deubiquitinates PTEN (Bos taurus)
REACT:R-CFA-191999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Canis familiaris)
REACT:R-GGA-8987141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Gallus gallus)
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phospho-D-glycerate hydro-lyase activity
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nervous-system specific enolase
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-enolase activity
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopyruvate hydratase activity
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enolase activity
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phosphoglycerate dehydratase activity
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phosphoglycerate enolase activity
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate hydratase activity
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phosphoglyceric dehydratase activity
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	14-3-2-protein
GO:0004634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phospho-D-glycerate-hydrolase activity
RHEA:53591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D2 <=> 16-oxoresolvin D2 + H(+) + NADH
REACT:R-HSA-6810357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fillagrin and keratin intermediate filaments polymerise forming a network (Homo sapiens)
REACT:R-HSA-164520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Minus strand DNA synthesis resumes (Homo sapiens)
RHEA:71953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(in) + sulfate(in) => 3 Na(+)(out) + sulfate(out)
RHEA:46020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[pyruvate, water dikinase] kinase"
RHEA:46020	skos:altLabel	"PEPS kinase"
RHEA:46020	skos:altLabel	"PSRP"
RHEA:46020	skos:prefLabel	"[pyruvate, water dikinase] kinase"
RHEA:46020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate, water dikinase] + ADP = [pyruvate, water dikinase]-phosphate + AMP + H(+)
REACT:R-BTA-76354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vinyl chloride is oxidized to 2-Chloroethylene oxide (Bos taurus)
GO:0018834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dichloromethane chloride-lyase (chloride-hydrolysing)
GO:0018834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)
GO:0018834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichloromethane dehalogenase activity
RHEA:49580	skos:prefLabel	"cyclic pyranopterin monophosphate synthase"
RHEA:49580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclic pyranopterin monophosphate synthase"
RHEA:49580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate
RHEA:60983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxydodecanoate + NAD(+) <=> 12-oxododecanoate + H(+) + NADH
GO:0031681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-beta protein subunit binding
GO:0031681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta-subunit binding
GO:0008754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O antigen ligase activity
RHEA:43784	skos:altLabel	"25S rRNA m(1)A(2142) methyltransferase"
RHEA:43784	skos:prefLabel	"25S rRNA (adenine(2142)-N(1))-methyltransferase"
RHEA:43784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine
RHEA:43784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"25S rRNA (adenine(2142)-N(1))-methyltransferase"
RHEA:39079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydodecanedioyl-CoA + NAD(+) = 3-oxododecanedioyl-CoA + H(+) + NADH
RHEA:43889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine => [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine
RHEA:36549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(octadecanoyl)-sphinganine => octadecanoyl-CoA + sphinganine
RHEA:17418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate
RHEA:39274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z)-tetracosenoyl-CoA <=> (2E,15Z)-tetracosadienoyl-CoA + H2O
RHEA:11491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + an acyl-CoA <=> an all-trans-retinyl ester + CoA
REACT:R-HSA-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Homo sapiens)
RHEA:13385	skos:altLabel	"beta-ketoacyl decarboxylase"
RHEA:13385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxolaurate decarboxylase"
RHEA:13385	skos:altLabel	"beta-ketolaurate decarboxylase"
RHEA:13385	skos:altLabel	"3-oxododecanoate carboxy-lyase"
RHEA:13385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoate + H(+) = 2-undecanone + CO2
RHEA:13385	skos:prefLabel	"3-oxolaurate decarboxylase"
RHEA:18991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropan-1-amine + CO2 => H(+) + L-valine
REACT:R-HSA-6797267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CD36 (Homo sapiens)
REACT:R-XTR-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Xenopus tropicalis)
REACT:R-SSC-8864569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds TFAP2C (Sus scrofa)
RHEA:38272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA => 3-methylfumaryl-CoA + H2O
GO:0102038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrobenzyl alcohol oxidase activity
REACT:R-DRE-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)
REACT:R-XTR-190260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b binds to FGF (Xenopus tropicalis)
RHEA:33640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + tetracosanoate => AMP + diphosphate + tetracosanoyl-CoA
REACT:R-CEL-2453833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)
RHEA:27891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-UMP + H2O => phosphate + uridine
RHEA:41549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-183089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)
RHEA:45750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA => (3Z)-hexenoyl-CoA
REACT:R-CEL-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Caenorhabditis elegans)
GO:0001790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polymeric immunoglobulin binding
REACT:R-SSC-8854044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)
REACT:R-RNO-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Rattus norvegicus)
RHEA:67049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chermesin D + O2 => A + asnovolin I + H2O
REACT:R-DDI-8937442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)
RHEA:43066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate
REACT:R-RNO-4086200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin matrix protein 1 binds integrin alphaVbeta3 (Rattus norvegicus)
RHEA:37002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Bos taurus)
REACT:R-HSA-1791150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)
REACT:R-HSA-9760103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2 binds the GCLM gene (Homo sapiens)
RHEA:62402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2S)-ephedrine + NAD(+)
REACT:R-HSA-2681694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Syndecan-3 (Homo sapiens)
REACT:R-CFA-8869580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEK binds TFAP2A homodimers (Canis familiaris)
GO:0015485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol binding
RHEA:68456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O
REACT:R-BTA-1678742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses Heparan sulfate chain(4) (Bos taurus)
REACT:R-CEL-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
REACT:R-DRE-6810392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMEM55B translocates to the nucleus (Danio rerio)
RHEA:30831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose
REACT:R-HSA-8948226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Homo sapiens)
REACT:R-HSA-8983841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 associates with IL6ST:IL6ST (Homo sapiens)
RHEA:65581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + TTP => H(+) + phosphate + TDP
RHEA:12405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + UDP-alpha-D-galactose => H(+) + lactose + UDP
REACT:R-BTA-9708423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1:BACH1:Hemes are transported out of the nucleus (Bos taurus)
RHEA:54954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + nonanoyl-CoA => ATP + CoA + nonanoate
REACT:R-RNO-4093331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras:GTP binds p120-RasGAP (Rattus norvegicus)
REACT:R-SSC-141202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates TYR (Sus scrofa)
RHEA:72793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin-glucuronoside(in) => bilirubin-glucuronoside(out)
REACT:R-HSA-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Homo sapiens)
RHEA:51798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	colupulone + diphosphate + H(+) => deoxycohumulone + dimethylallyl diphosphate
EC:2.7.7.46	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gentamicin 2''-nucleotidyltransferase"
EC:2.7.7.46	skos:altLabel	"2''-aminoglycoside nucleotidyltransferase"
EC:2.7.7.46	skos:prefLabel	"gentamicin 2''-nucleotidyltransferase"
REACT:R-BTA-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Bos taurus)
REACT:R-SSC-6797627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPG hydrolyses L-Asn to L-Asp (Sus scrofa)
REACT:R-DRE-8938867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND3,(CCND1,CCND2) binds RUNX1 (Danio rerio)
RHEA:28275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-S-adenosyl-L-methionine => (R)-S-adenosyl-L-methionine
REACT:R-BTA-198941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCAM1 binds Integrin alpha4beta1 (Bos taurus)
REACT:R-CFA-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Canis familiaris)
RHEA:30070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H2O + NADP(+) <=> glycine betaine + 2 H(+) + NADPH
REACT:R-DDI-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)
RHEA:50814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-5696197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Canis familiaris)
RHEA:66336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(out) = L-glutamate(in)
REACT:R-XTR-9652580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Xenopus tropicalis)
REACT:R-XTR-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Xenopus tropicalis)
REACT:R-HSA-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)
REACT:R-DRE-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Danio rerio)
REACT:R-SSC-212004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Sus scrofa)
RHEA:15408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) <=> [(3R)-hydroxybutanoate](n+1) + CoA
REACT:R-SPO-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Schizosaccharomyces pombe)
RHEA:45979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)
RHEA:60183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-fructose(out) + H2O <=> ADP + D-fructose(in) + H(+) + phosphate
RHEA:34874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol(out) <=> methanol(in)
REACT:R-DRE-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)
REACT:R-SSC-5668545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK autophosphorylates on T559 (Sus scrofa)
GO:0140678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular function inhibitor activity
RHEA:63356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2
RHEA:11171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) <=> 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH
REACT:R-MMU-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Mus musculus)
REACT:R-BTA-9674529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds to TBXA2R (Bos taurus)
REACT:R-BTA-5591040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves Factor Va intermediate form for Factor Va (Bos taurus)
REACT:R-DME-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Drosophila melanogaster)
RHEA:54144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 = 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate
RHEA:24780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-13(2)-carboxypyropheophorbide a + H(+) = CO2 + pyropheophorbide a
REACT:R-SSC-2129357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin C-terminal processing (Sus scrofa)
RHEA:58418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H(+) + NADPH => (E)-4-hydroxynon-2-en-1-ol + NADP(+)
REACT:R-RNO-5687484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Rattus norvegicus)
REACT:R-CEL-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Caenorhabditis elegans)
REACT:R-MMU-6785213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer binds heparin (Mus musculus)
RHEA:24335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-3,5-dihydromonacolin L carboxylate <=> H2O + monacolin L carboxylate
REACT:R-DME-163670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear transport of pChREBP (Thr 666) protein (Drosophila melanogaster)
RHEA:15887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + H(+) + NADPH => NADP(+) + propane-1,2-diol
RHEA:53973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
REACT:R-CFA-9645442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Canis familiaris)
REACT:R-RNO-1006169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds host cell surface markers (Rattus norvegicus)
GO:0061650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein conjugating enzyme activity
GO:0061650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conjugating protein conjugating enzyme activity
GO:0061650	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
REACT:R-MMU-2022911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSPG is secreted (Mus musculus)
RHEA:11748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fluorothreonine transaldolase"
RHEA:11748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetaldehyde + L-threonine = 4-fluoro-L-threonine + acetaldehyde
RHEA:11748	skos:prefLabel	"fluorothreonine transaldolase"
REACT:R-GGA-73758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Gallus gallus)
REACT:R-BTA-629588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Bos taurus)
RHEA:70202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopaminechrome <=> 5,6-dihydroxyindole
REACT:R-CFA-9674127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)
RHEA:56118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-decaprenylphenol + H(+) + NADPH + O2
RHEA:17963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene A4 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
REACT:R-BTA-8862771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G2A binds bacterial phospholipids (Bos taurus)
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichol-phosphate-mannose synthase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosylphosphoryldolichol synthase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPM synthase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl mannosyl phosphate synthase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosylphosphodolichol synthase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol phosphate mannose synthase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-phosphate beta-D-mannosyltransferase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-phosphate mannose synthase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol-phosphate mannose synthase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-phospho-mannose synthase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPmannose-dolichylmonophosphate mannosyltransferase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPmannose:dolichyl-phosphate mannosyltransferase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose-dolichol phosphate mannosyltransferase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl phosphate mannosyltransferase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPMan:DolP mannosyltransferase activity
GO:0004582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol-phosphate mannosyltransferase activity
REACT:R-MMU-140748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Mus musculus)
RHEA:50591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-PGF2alpha + NADP(+) <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH
RHEA:62910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + toralactone => nor-toralactone + S-adenosyl-L-methionine
GO:0102366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-beta-hydroxytaxusin 2-alpha-hydroxylase activity
GO:0140069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone butyryltransferase activity
RHEA:67069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chermesin D methyl ester => A + asnovolin J
REACT:R-DME-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Drosophila melanogaster)
REACT:R-MMU-202466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Bcl10 to CARMA1 (Mus musculus)
REACT:R-CFA-5205822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-18 (H3R17) of histone H3 (Canis familiaris)
GO:0140822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E35 specific)
GO:0140822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone H2B-E35 glutamate ADP-ribosyltransferase activity
GO:0140822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity
REACT:R-DRE-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Danio rerio)
REACT:R-BTA-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Bos taurus)
REACT:R-SSC-5603114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Sus scrofa)
RHEA:66805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate
REACT:R-CFA-5357904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Canis familiaris)
REACT:R-HSA-9687625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds MLKL (Homo sapiens)
EC:1.2.1.18	skos:prefLabel	"malonate-semialdehyde dehydrogenase (acetylating)"
EC:1.2.1.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malonate-semialdehyde dehydrogenase (acetylating)"
REACT:R-DRE-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Danio rerio)
REACT:R-SSC-5654423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Sus scrofa)
RHEA:65351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA <=> 3-oxochol-4,6-dien-24-oyl-CoA + H2O
REACT:R-HSA-5602272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP4F22 does not 20-hydroxylate TrXA3 (Homo sapiens)
RHEA:46181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoate + ATP + CoA => 2-methylbutanoyl-CoA + AMP + diphosphate
REACT:R-GGA-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Gallus gallus)
REACT:R-HSA-391157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds SKAP2 (Homo sapiens)
REACT:R-HSA-1183032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GLUT4 (Homo sapiens)
RHEA:25364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) => H(+) + momilactone A + NADH
GO:0005534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose binding lectin
GO:0005534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose binding
RHEA:36828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioscin + 3 H2O => D-glucose + diosgenin + 2 L-rhamnopyranose
REACT:R-MMU-5610720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI3 (Mus musculus)
REACT:R-CFA-3465448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)
RHEA:60365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + myo-inositol(out) => H(+)(in) + myo-inositol(in)
EC:3.4.17.3	skos:altLabel	"anaphylatoxin inactivator"
EC:3.4.17.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine carboxypeptidase"
EC:3.4.17.3	skos:altLabel	"carboxypeptidase N"
EC:3.4.17.3	skos:altLabel	"lysine(arginine) carboxypeptidase"
EC:3.4.17.3	skos:altLabel	"kininase I"
EC:3.4.17.3	skos:prefLabel	"lysine carboxypeptidase"
EC:3.4.17.3	skos:altLabel	"arginine carboxypeptidase"
REACT:R-BTA-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Bos taurus)
REACT:R-HSA-1678944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Homo sapiens)
REACT:R-GGA-114560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adhesion of integrin alphaIIbbeta3 to fibrin network (Gallus gallus)
REACT:R-SPO-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Schizosaccharomyces pombe)
REACT:R-DRE-1454781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Danio rerio)
RHEA:33258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-7 + S-adenosyl-L-methionine <=> H(+) + menaquinol-7 + S-adenosyl-L-homocysteine
RHEA:50274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	resolvin E1 => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
RHEA:35874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-HSA-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Homo sapiens)
RHEA:40826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate
REACT:R-SSC-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Sus scrofa)
REACT:R-SPO-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Schizosaccharomyces pombe)
RHEA:50855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
REACT:R-HSA-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)
REACT:R-HSA-2029459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Homo sapiens)
REACT:R-DDI-212004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Dictyostelium discoideum)
REACT:R-BTA-9679045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR9 dimer binds HCQ (Bos taurus)
REACT:R-HSA-140217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transactivation of PMAIP1 (NOXA) by E2F1 (Homo sapiens)
RHEA:32262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1-phosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde
RHEA:10638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannuronate + H(+) + NADPH => D-mannonate + NADP(+)
REACT:R-HSA-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Homo sapiens)
REACT:R-CFA-2168038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XV restin release (Canis familiaris)
REACT:R-HSA-9694281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)
REACT:R-RNO-2512800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1:ligand is endocytosed (Rattus norvegicus)
REACT:R-HSA-8983519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL35 binds IL12RB2:IL12RB2 receptor (Homo sapiens)
RHEA:13050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate => D-fructuronate
REACT:R-CFA-5654169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 (Canis familiaris)
REACT:R-HSA-9008475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
RHEA:23787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
RHEA:25333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH
REACT:R-RNO-77338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Rattus norvegicus)
REACT:R-GGA-434989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA7A binds to PLXNC1 (Gallus gallus)
GO:0062154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-methyl-AMP/dAMP aminohydrolase
GO:0062154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine
GO:0062154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPDA
GO:0062154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-methyl-AMP deaminase activity
GO:0062154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-mAMP deaminase activity
RHEA:55966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP
REACT:R-CFA-9700120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTN and MDK bind to PTPRZ (Canis familiaris)
REACT:R-SSC-5694433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 binds PREB (Sus scrofa)
REACT:R-HSA-8986294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds GLI2 (Homo sapiens)
REACT:R-MMU-9632034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GlcA to chondroitin (Mus musculus)
RHEA:51311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl-[F-actin] + NADPH + O2 <=> H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine carbamoyltransferase activity
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ornithine carbamyltransferase activity
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine carbamyltransferase activity
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrulline phosphorylase activity
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamylphosphate-ornithine transcarbamylase activity
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate:L-ornithine carbamoyltransferase activity
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OTCase activity
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine transcarbamylase activity
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ornithine carbamoyltransferase activity
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OTC activity
GO:0004585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ornithine transcarbamylase activity
REACT:R-RNO-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Rattus norvegicus)
RHEA:65294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate => 2 ATP + butan-2-one + 3 H2O + hydrogencarbonate
RHEA:59730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA
REACT:R-HSA-9617758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300,CREBBP acetylate FOXO4 (Homo sapiens)
RHEA:70324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxo-L-gulonate => 2-carboxy-L-lyxonolactone
REACT:R-MMU-8848751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds AKT1 (Mus musculus)
REACT:R-HSA-5672958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from KSR1:MARK3 (Homo sapiens)
REACT:R-MMU-3928601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 and PIP2 bind WASL, activating it (Mus musculus)
REACT:R-DDI-5692764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 binds CCND3 (Dictyostelium discoideum)
RHEA:72522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate <=> 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)
RHEA:41510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-hydroxy-L-ornithine + NADP(+) => L-ornithine + NADPH + O2
REACT:R-BTA-1250280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin (Bos taurus)
REACT:R-BTA-9021601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Bos taurus)
REACT:R-HSA-9617370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-antagonists bind ADRA1A,B,D (Homo sapiens)
RHEA:61105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Danio rerio)
REACT:R-BTA-5099886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binding to FZD promotes PRICKLE1 degradation (Bos taurus)
RHEA:14292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate + ATP + CoA <=> AMP + diphosphate + omega-dicarboxyl-CoA
REACT:R-HSA-3134901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRR FLII-interacting protein 1 associates with beta-catenin (Homo sapiens)
RHEA:56357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)
RHEA:42400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--lactose phosphotransferase"
RHEA:42400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + lactose 6-phosphate(in)
RHEA:42400	skos:prefLabel	"protein-N(pi)-phosphohistidine--lactose phosphotransferase"
RHEA:42400	skos:altLabel	"lactose PTS permease"
REACT:R-DME-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Drosophila melanogaster)
REACT:R-BTA-8981606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin binds oxygen (Bos taurus)
REACT:R-XTR-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Xenopus tropicalis)
RHEA:63875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-isoleucine + O2 <=> 3(1)-hydroxy-L-isoleucine + CO2 + succinate
RHEA:61495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + an ultra-long-chain fatty acyl-CoA <=> an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)
RHEA:28355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + FAD + H(+) => (2E)-decenoyl-CoA + FADH2
REACT:R-BTA-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)
REACT:R-GGA-8934465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds PTPN12 (Gallus gallus)
RHEA:41068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)
RHEA:45351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine
GO:0001571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-tyrosine kinase FGFR activity
GO:0001571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-tyrosine kinase fibroblast growth factor receptor activity
GO:0001571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-tyrosine kinase FGF receptor activity
REACT:R-RNO-9020264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Rattus norvegicus)
RHEA:68444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal
GO:0046995	skos:prefLabel	"With other, known, acceptors"
GO:0046995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on hydrogen as donor, with other known acceptors
GO:0046995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
RHEA:53663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate
RHEA:52653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol + S-adenosyl-L-methionine => eburicol + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-114548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Mus musculus)
RHEA:44423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)
RHEA:65930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine => 3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine
REACT:R-MMU-373750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:ErbB2 (Mus musculus)
GO:0047834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, L-fucose
GO:0047834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-aldose 1-dehydrogenase activity
GO:0047834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fucose dehydrogenase activity
GO:0047834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S,3R)-aldose dehydrogenase activity
GO:0047834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fucose (D-arabinose) dehydrogenase activity
GO:0047834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-threo-aldose:NAD+ 1-oxidoreductase activity
RHEA:19548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 3-phosphocholine <=> glycerol + H(+) + phosphocholine
RHEA:48263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1 <=> CMP + ganglioside GD1a + H(+)
REACT:R-SSC-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Sus scrofa)
REACT:R-GGA-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Gallus gallus)
REACT:R-SSC-9645535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 phosphorylates TIFA (Sus scrofa)
REACT:R-BTA-5687097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3 binds ETV4 (Bos taurus)
REACT:R-DME-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
RHEA:56584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-epoxypropane + H2O = propane-1,2-diol
RHEA:33845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + tetracosanoate => H2O + N-tetracosanoylsphinganine
REACT:R-SSC-174374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 from MeCbl to HCYS (Sus scrofa)
REACT:R-CFA-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Canis familiaris)
REACT:R-GGA-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Gallus gallus)
RHEA:62769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
RHEA:40502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine
REACT:R-BTA-5676607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF,sAPRIL binds TACI,BCMA (Bos taurus)
REACT:R-SSC-374758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Somatostatin receptors bind somatostatin and cortistatin (Sus scrofa)
RHEA:19908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + spermidine <=> dehydrospermidine + H(+) + NADH
GO:0022819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium ion uniporter activity
REACT:R-CEL-209055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
REACT:R-HSA-9761830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds the TALDO1 gene (Homo sapiens)
RHEA:36027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + propanal = H(+) + NADH + propanoyl-CoA
RHEA:36027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"propanal dehydrogenase (CoA-propanoylating)"
RHEA:36027	skos:prefLabel	"propanal dehydrogenase (CoA-propanoylating)"
RHEA:37498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-SSC-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Sus scrofa)
REACT:R-HSA-429683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Homo sapiens)
EC:3.4.17.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxypeptidase A2"
EC:3.4.17.15	skos:prefLabel	"carboxypeptidase A2"
REACT:R-HSA-9754827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 M binds TBK1 (Homo sapiens)
REACT:R-HSA-159783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
REACT:R-XTR-2187325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 ADP-ribosylates SMAD3 and SMAD4 (Xenopus tropicalis)
REACT:R-CFA-432195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Canis familiaris)
GO:1902936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol bisphosphate binding
REACT:R-CFA-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Canis familiaris)
REACT:R-HSA-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Homo sapiens)
REACT:R-RNO-4570499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Rattus norvegicus)
REACT:R-HSA-5696457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDH2 dehydrogenates 3HBA (Homo sapiens)
REACT:R-DDI-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Dictyostelium discoideum)
REACT:R-XTR-6784324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Xenopus tropicalis)
REACT:R-MMU-5666001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Profilin:G-actin binds MKL1 (Mus musculus)
REACT:R-DME-975629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11 reduces RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)
GO:0016160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amylase activity
REACT:R-MMU-4085021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Mus musculus)
REACT:R-RNO-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Rattus norvegicus)
RHEA:72070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + ATP + L-glutamate <=> ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate
RHEA:61935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-miconazole(in) + ATP + H2O <=> (S)-miconazole(out) + ADP + H(+) + phosphate
REACT:R-GGA-3361751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin is replaced by repression complexes at the promoter (Gallus gallus)
GO:0102014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactose-importing ATPase activity
RHEA:43302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-CFA-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Canis familiaris)
RHEA:43305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer => 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)
REACT:R-RNO-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
RHEA:43487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
REACT:R-BTA-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Bos taurus)
RHEA:62688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 norrubrofusarin + O2 = 2 H2O + 2 ustilaginoidin A
RHEA:34470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + valerena-4,7(11)-diene
RHEA:61987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + ubiquinone-10 <=> NAD(+) + ubiquinol-10
REACT:R-CEL-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Caenorhabditis elegans)
REACT:R-RNO-426223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cation influx mediated by TRPC3/6/7 (Rattus norvegicus)
REACT:R-SCE-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Saccharomyces cerevisiae)
RHEA:24021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(N(omega)-L-arginino)succinate => fumarate + L-arginine
REACT:R-CFA-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)
RHEA:13338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucurono-6,2-lactone + H2O => D-glucuronate + H(+)
RHEA:53012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichlorohydroquinone + 2 glutathione = chloride + chlorohydroquinone + glutathione disulfide + H(+)
REACT:R-BTA-264997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cysteine to cystine in Proinsulin (Bos taurus)
GO:0008762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity
GO:0008762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MurB reductase
GO:0008762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine-enoylpyruvate reductase activity
GO:0008762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylenolpyruvoylglucosamine reductase activity
GO:0008762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylpyruvoylglucosamine reductase activity
GO:0008762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramate:NADP+ oxidoreductase activity
GO:0008762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity
GO:0008762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramate dehydrogenase activity
GO:0008762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc-enoylpyruvate reductase activity
REACT:R-SSC-5638141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Sus scrofa)
REACT:R-DRE-877281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 binds p-STAT1 dimer (Danio rerio)
REACT:R-SSC-5610760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)
REACT:R-HSA-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Homo sapiens)
RHEA:13976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+)(in) + H2O <=> 2 H(+)(out) + 2 phosphate
REACT:R-HSA-4551679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)
RHEA:17124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + L-lysine <=> H(+) + L-homocitrulline + phosphate
REACT:R-HSA-5668947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates myosin phosphatase (Homo sapiens)
REACT:R-MMU-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Mus musculus)
REACT:R-SSC-983425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Sus scrofa)
REACT:R-HSA-429798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Homo sapiens)
RHEA:63658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
RHEA:31436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate
REACT:R-BTA-198824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Bos taurus)
RHEA:25254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-mannosamine => ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate
RHEA:26194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + ATP + CoA => (S)-malyl-CoA + ADP + phosphate
REACT:R-CEL-9609742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Caenorhabditis elegans)
RHEA:10447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + S-adenosyl-L-methionine <=> (S)-laudanine + H(+) + S-adenosyl-L-homocysteine
RHEA:22195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
RHEA:58216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydroserpentine = AH2 + serpentine
REACT:R-BTA-9714361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC activates endoplasmic reticulum effectors (Bos taurus)
REACT:R-DRE-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)
RHEA:30043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + L-aspartate = iminosuccinate + succinate
REACT:R-XTR-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Xenopus tropicalis)
RHEA:40897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-BTA-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Bos taurus)
RHEA:53019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorohydroquinone + 2 glutathione <=> chloride + glutathione disulfide + H(+) + hydroquinone
RHEA:58668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH
REACT:R-XTR-8951499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides on to class I MHC (Xenopus tropicalis)
REACT:R-SPO-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Schizosaccharomyces pombe)
RHEA:35989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA
REACT:R-RNO-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Rattus norvegicus)
REACT:R-MMU-9624668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDKN1A (p21) (Mus musculus)
RHEA:42752	skos:prefLabel	"23S rRNA (pseudouridine(1915)-N(3))-methyltransferase"
RHEA:42752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (pseudouridine(1915)-N(3))-methyltransferase"
RHEA:42752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:42752	skos:altLabel	"rRNA large subunit methyltransferase H"
RHEA:42752	skos:altLabel	"Psi(1915)-specific methyltransferase"
RHEA:42752	skos:altLabel	"pseudouridine methyltransferase"
RHEA:22569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascopyrone M => ascopyrone P
REACT:R-SSC-373086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR10 binds CCL27 and 28 ligands (Sus scrofa)
REACT:R-BTA-433131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC1 co-transports dicarboxylic acids and a sodium ion (Bos taurus)
REACT:R-MMU-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Mus musculus)
RHEA:18826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->6)-alpha-D-glucosyl](n) + sucrose => [(1->6)-alpha-D-glucosyl](n+1) + D-fructose
RHEA:10566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methanol + oxaloacetate => H2O + oxaloacetate 4-methyl ester
RHEA:27982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-cyano-7-deazaguanine synthase"
RHEA:27982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate
RHEA:27982	skos:altLabel	"preQ0 synthase"
RHEA:27982	skos:altLabel	"7-cyano-7-carbaguanine synthase"
RHEA:27982	skos:prefLabel	"7-cyano-7-deazaguanine synthase"
RHEA:27286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-acetoin + NAD(+) = diacetyl + H(+) + NADH
RHEA:27286	skos:prefLabel	"diacetyl reductase [(S)-acetoin forming]"
RHEA:27286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diacetyl reductase [(S)-acetoin forming]"
RHEA:27286	skos:altLabel	"(S)-acetoin dehydrogenase"
RHEA:70562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-galactosamine
REACT:R-XTR-2028284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Xenopus tropicalis)
RHEA:65162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexan-2-yl benzoate => benzoyl-CoA + hexan-2-ol
REACT:R-DDI-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Dictyostelium discoideum)
REACT:R-RNO-5218851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Rattus norvegicus)
RHEA:64074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O => acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA
REACT:R-MMU-2404199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:IGF1R autophosphorylates (Mus musculus)
REACT:R-HSA-6807581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTN5, (HTN1, HTN3) binds fungal SSA1/SSA2 (Homo sapiens)
REACT:R-MMU-70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer oxidises LACT to PYR (Mus musculus)
REACT:R-XTR-416725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA6D binds to PLXNA1:TREM2:DAP12 (Xenopus tropicalis)
REACT:R-CFA-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
REACT:R-MMU-265296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Mus musculus)
REACT:R-RNO-9619756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2 binds ABCA1 (Rattus norvegicus)
REACT:R-GGA-9009558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds SDC1 (Gallus gallus)
REACT:R-RNO-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Rattus norvegicus)
RHEA:24544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-lysine 6-oxidase"
RHEA:24544	skos:prefLabel	"protein-lysine 6-oxidase"
RHEA:24544	skos:altLabel	"lysyl oxidase"
RHEA:24544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)
REACT:R-HSA-141671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)
REACT:R-HSA-936985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)
RHEA:47085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-methionine
RHEA:54610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]
REACT:R-DDI-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Dictyostelium discoideum)
REACT:R-HSA-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)
REACT:R-GGA-9647660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds PIPs (Gallus gallus)
RHEA:52705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UMP => D-ribose 5-phosphate + uracil
RHEA:50032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine
REACT:R-HSA-9613460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ID1 and ID3 gene expression (Homo sapiens)
RHEA:38649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O
REACT:R-BTA-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Bos taurus)
RHEA:39825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O => eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:1902121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholic acid binding
GO:1902121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCA binding
REACT:R-SSC-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Sus scrofa)
RHEA:30242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n a quinone + n H(+) + n hydrogen sulfide <=> n a quinol + n sulfur
REACT:R-CFA-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Canis familiaris)
REACT:R-GGA-9013111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GAPs stimulate RHOC GTPase activity (Gallus gallus)
RHEA:38266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O
RHEA:68336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphate
REACT:R-XTR-9032798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK3 activates RAC1 (Xenopus tropicalis)
RHEA:53119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11beta-hydroxysteroid + NAD(+) <=> an 11-oxosteroid + H(+) + NADH
REACT:R-CFA-204773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb7 (Canis familiaris)
REACT:R-HSA-9759147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 and MAFG bind the SQSTM1 gene (Homo sapiens)
RHEA:53712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heme ligase"
RHEA:53712	skos:altLabel	"hemozoin synthase"
RHEA:53712	skos:prefLabel	"heme ligase"
RHEA:53712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-heme b = beta-hematin
RHEA:25843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-glucuronate <=> 5-dehydro-2-deoxy-D-gluconate
REACT:R-DME-8954398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer hydrolyses cardiolipin to PA and PG (Drosophila melanogaster)
REACT:R-SCE-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Saccharomyces cerevisiae)
RHEA:67186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine
REACT:R-MMU-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Mus musculus)
REACT:R-BTA-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Bos taurus)
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	indolamine 2,3-dioxygenase activity
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptamin 2,3-dioxygenase activity
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tryptophan oxygenase activity
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan pyrrolase activity
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDO
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Homo sapiens)
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan 2,3-dioxygenase activity
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan 2,3-dioxygenase activity
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tryptophan pyrrolase activity
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoleamine-pyrrole 2,3-dioxygenase activity
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptamine 2,3-dioxygenase activity
GO:0004833	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tryptophan peroxidase activity
RHEA:49388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + validoxylamine A = H(+) + UDP + validamycin A
RHEA:49388	skos:prefLabel	"validoxylamine A glucosyltransferase"
RHEA:49388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"validoxylamine A glucosyltransferase"
REACT:R-SSC-77277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Sus scrofa)
REACT:R-CFA-8938770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Canis familiaris)
EC:1.1.1.261	skos:altLabel	"Gro1PDH"
EC:1.1.1.261	skos:altLabel	"glycerol-1-phosphate dehydrogenase [NAD(P)(+)]"
EC:1.1.1.261	skos:prefLabel	"sn-glycerol-1-phosphate dehydrogenase"
EC:1.1.1.261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sn-glycerol-1-phosphate dehydrogenase"
REACT:R-SSC-8854905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)
RHEA:38391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)
REACT:R-BTA-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Bos taurus)
REACT:R-RNO-5691411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Rattus norvegicus)
RHEA:21317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phorbol 12,13-dibutanoate => butanoate + H(+) + phorbol 13-butanoate
GO:0018825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triethanolamine lyase activity
RHEA:39532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)
REACT:R-SPO-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Schizosaccharomyces pombe)
REACT:R-HSA-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Homo sapiens)
REACT:R-SCE-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Saccharomyces cerevisiae)
RHEA:44576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) = 2-all-trans-nonaprenylphenol + CO2
RHEA:31438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate
REACT:R-HSA-381704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G(s):GTP activates Adenylyl cyclase (Homo sapiens)
RHEA:57828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + H2O = 2-deoxy-D-ribose 5-phosphate + hypoxanthine
REACT:R-CEL-8875558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 binds CRK,CRKL (Caenorhabditis elegans)
EC:1.1.1.24	skos:prefLabel	"quinate/shikimate dehydrogenase (NAD(+))"
EC:1.1.1.24	skos:altLabel	"quinic dehydrogenase"
EC:1.1.1.24	skos:altLabel	"quinate 5-dehydrogenase"
EC:1.1.1.24	skos:altLabel	"quinate dehydrogenase"
EC:1.1.1.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinate/shikimate dehydrogenase (NAD(+))"
REACT:R-GGA-1678923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR folding by chaperones GP96 and CNPY3 (Gallus gallus)
REACT:R-GGA-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Gallus gallus)
RHEA:68416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methanogen homoaconitase"
RHEA:68416	skos:altLabel	"methanogen HACN"
RHEA:68416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-(homo)2aconitate + H2O = (2R,3S)-iso(homo)2citrate
RHEA:68416	skos:prefLabel	"methanogen homoaconitase"
GO:0102212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	unsaturated chondroitin disaccharide hydrolase activity
RHEA:69882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + retinal <=> H(+) + H2O2 + retinoate
RHEA:42777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine
GO:0015252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton channel activity
GO:0015252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen ion channel activity
RHEA:23036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O
GO:0000810	skos:altLabel	"pyrophosphate phosphatase"
GO:0000810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol diphosphate phosphatase activity
GO:0000810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGPP phosphatase activity
GO:0000810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diacylglycerol diphosphate phosphatase"
GO:0000810	skos:altLabel	"DGPP phosphohydrolase"
GO:0000810	skos:altLabel	"DGPP phosphatase"
GO:0000810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate
GO:0000810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGPP phosphohydrolase activity
GO:0000810	skos:prefLabel	"diacylglycerol diphosphate phosphatase"
GO:0000810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol pyrophosphate phosphatase activity
REACT:R-RNO-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Rattus norvegicus)
REACT:R-RNO-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Rattus norvegicus)
RHEA:32102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + TRIBOA beta-D-glucoside <=> DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine
GO:0120014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipid carrier activity
GO:0120014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipid transfer activity
GO:0120014	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane phospholipid transfer activity
RHEA:11517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + succinyl-CoA => CoA + H(+) + succinate
RHEA:51803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadlupulone + dimethylallyl diphosphate <=> adlupulone + diphosphate + H(+)
REACT:R-RNO-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Rattus norvegicus)
REACT:R-SCE-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Saccharomyces cerevisiae)
REACT:R-RNO-9639287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2 binds L-leucine and dissociates from GATOR2 (Rattus norvegicus)
REACT:R-GGA-2465924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1LW binds 11cRAL (Gallus gallus)
RHEA:59902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate => 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2
REACT:R-CFA-2161195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Canis familiaris)
REACT:R-XTR-870437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) deubiquitinates SMAD4 (Xenopus tropicalis)
REACT:R-HSA-6800299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)
REACT:R-CFA-2997616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Canis familiaris)
RHEA:38696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin(in) => a cardiolipin(out)
RHEA:31347	skos:altLabel	"ABA-beta-D-glucosidase"
RHEA:31347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-abscisic acid D-glucopyranosyl ester + H2O = 2-cis-(+)-abscisate + beta-D-glucose + H(+)
RHEA:31347	skos:prefLabel	"beta-D-glucopyranosyl abscisate beta-glucosidase"
RHEA:31347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-D-glucopyranosyl abscisate beta-glucosidase"
RHEA:31347	skos:altLabel	"beta-D-glucopyranosyl abscisate hydrolase"
REACT:R-XTR-8983378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Xenopus tropicalis)
RHEA:25543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate <=> diphosphate + ent-pimara-8(14),15-diene
REACT:R-CFA-8876484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 transfers CHOL to NPC1 (Canis familiaris)
REACT:R-MMU-8983384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Mus musculus)
REACT:R-RNO-5654165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR1 (Rattus norvegicus)
REACT:R-DME-9660192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR agonists bind VDR (Drosophila melanogaster)
REACT:R-CFA-2130500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of MHC II:Ii complex in to the plasma membrane (Canis familiaris)
RHEA:51385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + serotonin => CoA + H(+) + N-hexadecanoyl-serotonin
REACT:R-SCE-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Saccharomyces cerevisiae)
REACT:R-CEL-77338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)
REACT:R-MMU-200423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Mus musculus)
REACT:R-MMU-5675947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF18 binds TNFRSF18 (Mus musculus)
RHEA:62657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate
RHEA:10587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)
RHEA:72511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + 2-oxoglutarate(in) = (R)-carnitine(in) + 2-oxoglutarate(out)
REACT:R-CEL-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Caenorhabditis elegans)
REACT:R-GGA-390835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD1,5 bind DA (Gallus gallus)
RHEA:38867	skos:altLabel	"16S RNA Psi(516) synthase"
RHEA:38867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(516) in 16S rRNA = pseudouridine(516) in 16S rRNA
RHEA:38867	skos:altLabel	"16S RNA pseudouridine(516) synthase"
RHEA:38867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA pseudouridine(516) synthase"
RHEA:38867	skos:altLabel	"16S RNA pseudouridine 516 synthase"
RHEA:38867	skos:prefLabel	"16S rRNA pseudouridine(516) synthase"
RHEA:32476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + 3 S-adenosyl-L-methionine => glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-XTR-163010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Down Regulation of Emi1 through Phosphorylation of Emi1 (Xenopus tropicalis)
REACT:R-XTR-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Xenopus tropicalis)
REACT:R-CEL-71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Caenorhabditis elegans)
REACT:R-BTA-975103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Bos taurus)
REACT:R-SPO-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Schizosaccharomyces pombe)
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose 4-epimerase activity
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate glucose 4-epimerase activity
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose 4-epimerase activity
GO:0003978	skos:altLabel	"galactowaldenase"
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose = UDP-alpha-D-galactose
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose 4-epimerase activity
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG-4-epimerase activity
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-galactose 4-epimerase activity
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose epimerase activity
GO:0003978	skos:altLabel	"uridine diphosphate galactose 4-epimerase"
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-epimerase activity
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose epimerase activity
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose 4-epimerase activity
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphospho-galactose-4-epimerase activity
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactowaldenase activity
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-glucose 4-epimerase"
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate galactose 4-epimerase activity
GO:0003978	skos:prefLabel	"UDP-glucose 4-epimerase"
GO:0003978	skos:altLabel	"UDP-galactose 4-epimerase"
GO:0003978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose 4-epimerase activity
GO:0003978	skos:altLabel	"uridine diphospho-galactose-4-epimerase"
GO:0103063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-keto-C61-meroacyl-AMP ligase activity
RHEA:12683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylhydantoin + NH4(+) => creatinine + H(+) + H2O
REACT:R-BTA-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Bos taurus)
RHEA:56506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-XTR-9756162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 4-OH-ATV (Xenopus tropicalis)
RHEA:34351	skos:altLabel	"GaDH"
RHEA:34351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranial dehydrogenase"
RHEA:34351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranial + H2O + NAD(+) = geranate + 2 H(+) + NADH
RHEA:34351	skos:prefLabel	"geranial dehydrogenase"
REACT:R-GGA-1433508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC alpha interacts with and phosphorylates KIT (Gallus gallus)
RHEA:16658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + inosine => D-ribose + hypoxanthine
REACT:R-DRE-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Danio rerio)
RHEA:71009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(in) + L-tryptophan(out) => L-phenylalanine(out) + L-tryptophan(in)
REACT:R-CFA-8959719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPK phosphorylates Sedo to Sedo7P (Canis familiaris)
REACT:R-DME-200424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Drosophila melanogaster)
RHEA:17978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + H2O + 2 NAD(+) => a long-chain fatty acid + 3 H(+) + 2 NADH
RHEA:19509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pteridine reductase"
RHEA:19509	skos:altLabel	"pteridine reductase 1"
RHEA:19509	skos:altLabel	"PTR1"
RHEA:19509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 2 H(+) + L-erythro-biopterin + 2 NADPH
RHEA:19509	skos:prefLabel	"pteridine reductase"
RHEA:71923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) + taurochenodeoxycholate(in)
REACT:R-CFA-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Canis familiaris)
REACT:R-SPO-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)
REACT:R-SSC-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Sus scrofa)
REACT:R-MMU-4420099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHB  (Mus musculus)
RHEA:28635	skos:altLabel	"farnesyl pyrophosphate cyclase"
RHEA:28635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-epiaristolochene synthase"
RHEA:28635	skos:altLabel	"5-epi-aristolochene synthase"
RHEA:28635	skos:prefLabel	"5-epiaristolochene synthase"
RHEA:28635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-5-epi-aristolochene + diphosphate
EC:3.4.23.22	skos:prefLabel	"endothiapepsin"
EC:3.4.23.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endothiapepsin"
EC:3.4.23.22	skos:altLabel	"Endothia aspartic proteinase"
REACT:R-DRE-213175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 oxidise AFB1 to AFXBO (Danio rerio)
REACT:R-DRE-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Danio rerio)
REACT:R-SSC-110356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MPG glycosylase by APEX1 at the AP site (Sus scrofa)
REACT:R-XTR-1028816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Xenopus tropicalis)
RHEA:65135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + preaustinoid A1 <=> CO2 + H2O + preaustinoid A2 + succinate
REACT:R-DRE-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Danio rerio)
RHEA:60582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:18989	skos:prefLabel	"valine decarboxylase"
RHEA:18989	skos:altLabel	"L-valine carboxy-lyase"
RHEA:18989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-valine = 2-methylpropan-1-amine + CO2
RHEA:18989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valine decarboxylase"
REACT:R-CEL-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Caenorhabditis elegans)
REACT:R-CEL-5623643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH13 reduces atRAL to atROL (Caenorhabditis elegans)
RHEA:55873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) => 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH
REACT:R-BTA-377644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of CSK from SRC (Bos taurus)
REACT:R-DME-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Drosophila melanogaster)
REACT:R-GGA-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Gallus gallus)
REACT:R-DRE-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Danio rerio)
REACT:R-DRE-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Danio rerio)
REACT:R-MMU-9020255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Mus musculus)
REACT:R-RNO-8952062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 recruits HDAC4 to RUNX3 (Rattus norvegicus)
REACT:R-RNO-5693012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF15 binds TNFRSF25 (Rattus norvegicus)
REACT:R-SPO-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Schizosaccharomyces pombe)
RHEA:30887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin = 7,8-dihydropteroate + H2O
RHEA:48222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA
RHEA:65213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H2O => (2E)-dodecenoate + CoA + H(+)
REACT:R-DDI-73932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resynthesis of excised residue by POLB (Dictyostelium discoideum)
REACT:R-HSA-9682544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 binds nsp10 (Homo sapiens)
REACT:R-GGA-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Gallus gallus)
REACT:R-RNO-416530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1:FFAR1 ligands activates Gq (Rattus norvegicus)
REACT:R-CEL-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Caenorhabditis elegans)
REACT:R-HSA-4411372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF/LEF:CTNNB1 promote transcription of AXIN2 (Homo sapiens)
REACT:R-GGA-8857692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA demethylases demethylate N6-methyladenosine RNA (Gallus gallus)
RHEA:50973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
RHEA:49560	skos:prefLabel	"demethyl-4-deoxygadusol synthase"
RHEA:49560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethyl-4-deoxygadusol synthase"
RHEA:49560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate = (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate
GO:0004040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylamide amidohydrolase activity
GO:0004040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acylamidase activity
GO:0004040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amidohydrolase activity
GO:0004040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylaminohydrolase activity
GO:0004040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amidase activity
GO:0004040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetamidase activity
GO:0004040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylamidase activity
GO:0004040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylase activity
REACT:R-SSC-2534248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP2, MMP3, MMP7 (Sus scrofa)
REACT:R-MMU-2294600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates condensin II subunit NCAPD3 (Mus musculus)
RHEA:13704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-homoserine <=> CoA + O-acetyl-L-homoserine
REACT:R-CEL-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Caenorhabditis elegans)
REACT:R-SSC-936985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1 recruits TRAF6 (Sus scrofa)
REACT:R-DME-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Drosophila melanogaster)
REACT:R-MMU-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Mus musculus)
RHEA:61272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminopentanoate + O2 = 2-oxopentanoate + H2O2 + NH4(+)
REACT:R-HSA-196350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Homo sapiens)
REACT:R-CFA-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Canis familiaris)
REACT:R-BTA-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Bos taurus)
RHEA:19904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 <=> alpha,beta-didehydrotryptophan + H2O2
REACT:R-MMU-373700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-9 binds DCC:DIP13alpha complex (Mus musculus)
REACT:R-GGA-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Gallus gallus)
GO:0102639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	paspalicine synthase activity
GO:0004848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ureidoglycolate hydrolase activity
GO:0004848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate amidohydrolase (decarboxylating)
REACT:R-HSA-4085331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-1 SUMOylates PARK7 with SUMO1 (Homo sapiens)
REACT:R-CEL-5626549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind CALM1 (Caenorhabditis elegans)
RHEA:60811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A19 + H(+) + O2 <=> CO2 + gibberellin A20 + H2O
RHEA:33913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkylamine + glyoxylate + H2O2 => an N-alkylglycine + H2O + O2
REACT:R-DRE-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Danio rerio)
REACT:R-SSC-1605632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Both hexosaminidase A and B can cleave GalNAc from globoside (Sus scrofa)
REACT:R-HSA-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Homo sapiens)
REACT:R-CFA-373732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin trans-homophilic interaction (Canis familiaris)
REACT:R-MMU-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Mus musculus)
GO:0018597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammonia monooxygenase activity
REACT:R-MMU-4720432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Mus musculus)
RHEA:40771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg1 + H2O = (20S)-ginsenoside F1 + D-glucose
RHEA:63665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)
RHEA:48236	skos:prefLabel	"2-acetylphloroglucinol acetyltransferase"
RHEA:48236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-acetylphloroglucinol acetyltransferase"
RHEA:48236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-acetylphloroglucinol = 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)
RHEA:48236	skos:altLabel	"MAPG ATase"
REACT:R-CFA-5432852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR4:LY96 (Canis familiaris)
REACT:R-DRE-209532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR C-terminal fragment enters endosomes (Danio rerio)
REACT:R-MMU-8871193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
RHEA:23823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose <=> GDP-4-dehydro-alpha-D-rhamnose + H2O
REACT:R-CFA-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Canis familiaris)
REACT:R-XTR-183055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to EGFR (Xenopus tropicalis)
REACT:R-GGA-174157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cyclin B (Gallus gallus)
REACT:R-CFA-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Canis familiaris)
REACT:R-XTR-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)
RHEA:64637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + butan-1-ol => butyl benzoate + CoA
REACT:R-BTA-158795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Bos taurus)
RHEA:60185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucose(out) + H2O => ADP + D-glucose(in) + H(+) + phosphate
GO:0033874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scymnol sulfotransferase activity
GO:0015150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucose transmembrane transporter activity
REACT:R-MMU-9759209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2 binds extracellular TCN2:RCbl (Mus musculus)
RHEA:31271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + naphthalene-1,2-diol
RHEA:50109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + taurine => CoA + H(+) + N-hexadecanoyl-taurine
REACT:R-RNO-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Rattus norvegicus)
REACT:R-HSA-196086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Homo sapiens)
RHEA:17352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate
RHEA:67656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + NADPH = 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)
REACT:R-XTR-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Xenopus tropicalis)
REACT:R-HSA-203070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of profilin with monomeric actin (Homo sapiens)
REACT:R-HSA-390674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB1 bind ADR,NAd (Homo sapiens)
RHEA:56054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
REACT:R-HSA-5591086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA5 binds activated protein C (Homo sapiens)
RHEA:69409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) => androst-4-ene-3,11,17-trione + H(+) + NADH
RHEA:70633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+)
REACT:R-RNO-5603467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C is released from PROCR (Rattus norvegicus)
REACT:R-DRE-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)
RHEA:20091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-L-leucine => acetyl-CoA + L-leucine
REACT:R-XTR-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Xenopus tropicalis)
GO:0047134	skos:prefLabel	"protein-disulfide reductase"
GO:0047134	skos:altLabel	"disulfide reductase"
GO:0047134	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein-disulfide reductase activity
GO:0047134	skos:altLabel	"protein disulfide reductase"
GO:0047134	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein-disulphide reductase activity
GO:0047134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-disulfide reductase"
GO:0047134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	insulin-glutathione transhydrogenase activity
GO:0047134	skos:altLabel	"insulin-glutathione transhydrogenase"
GO:0047134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein disulfide reductase activity
GO:0047134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein disulphide reductase activity
GO:0047134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:protein-disulfide oxidoreductase activity
GO:0047134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-disulfide reductase (NAD(P)) activity
GO:0047134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein disulfide reductase (NAD(P)H) activity
GO:0047134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	disulfide reductase activity
REACT:R-SPO-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Schizosaccharomyces pombe)
RHEA:69771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty aldehyde + H2O + NAD(+) = a short-chain fatty acid + 2 H(+) + NADH
REACT:R-BTA-3134804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING ubiquitination by TRIM32 or TRIM56 (Bos taurus)
REACT:R-CFA-2404137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)
REACT:R-MMU-2161195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Mus musculus)
REACT:R-DRE-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)
RHEA:18936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O
GO:0047641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent aldose 6-phosphate reductase activity
GO:0047641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldose-6-P reductase activity
GO:0047641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldose 6-phosphate reductase activity
GO:0047641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldose-6-phosphate reductase activity
GO:0047641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity
GO:0047641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alditol 6-phosphate:NADP 1-oxidoreductase activity
GO:0047641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldose-6-phosphate reductase (NADPH) activity
GO:0047641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity
GO:0047641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	A6PR
REACT:R-DRE-5607740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta phosphorylates CARD9 (Danio rerio)
REACT:R-XTR-1234164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Xenopus tropicalis)
REACT:R-HSA-4088306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXM1 binds PLK1 promoter (Homo sapiens)
REACT:R-MMU-5205824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Mus musculus)
REACT:R-HSA-3781021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex (Homo sapiens)
REACT:R-HSA-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Homo sapiens)
RHEA:68176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-geranyl-L-glutamate + O2 = CO2 + dainate A + H2O + succinate
GO:0019992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol binding
REACT:R-HSA-5082369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylated HSF1 dissociates from DNA (Homo sapiens)
REACT:R-GGA-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Gallus gallus)
RHEA:51935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite <=> 2 Fe(II)-[cytochrome c3] + thiosulfate
REACT:R-GGA-5607058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C:PROCR binds F2R (Gallus gallus)
RHEA:16836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + H2O2 <=> glutathione disulfide + 2 H2O
REACT:R-RNO-8987084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)
RHEA:22813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) => 5,10-methenyltetrahydrofolate + NADPH
RHEA:40762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate
REACT:R-RNO-9638125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G1P to G6P (Rattus norvegicus)
RHEA:48231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] <=> a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]
REACT:R-CFA-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Canis familiaris)
REACT:R-DRE-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Danio rerio)
REACT:R-HSA-3296126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)
REACT:R-MMU-9701003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 heterodimer (Mus musculus)
RHEA:56372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)
REACT:R-XTR-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Xenopus tropicalis)
REACT:R-XTR-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Xenopus tropicalis)
RHEA:69196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-glutamyl-[beta-tubulin] = ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate
REACT:R-CFA-159431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Canis familiaris)
REACT:R-HSA-396941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)
REACT:R-DME-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)
RHEA:48391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
REACT:R-DRE-1482827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Danio rerio)
REACT:R-BTA-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Bos taurus)
REACT:R-RNO-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Rattus norvegicus)
RHEA:57816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + H2O = 2-deoxy-D-ribose 5-phosphate + guanine
RHEA:30601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + all-trans-neurosporene => 15-cis-phytoene + 3 A
REACT:R-HSA-8866854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexose 1-phosphate guanylyltransferase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hexose-1-phosphate guanylyltransferase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GDP hexose pyrophosphorylase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GTP:hexose-1-phosphate guanylyltransferase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDP hexose pyrophosphorylase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NTP:hexose-1-phosphate nucleotidyltransferase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	guanosine diphosphohexose pyrophosphorylase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDP-hexose pyrophosphorylase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexose nucleotidylating enzyme activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexose 1-phosphate nucleotidyltransferase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside diphosphohexose pyrophosphorylase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity
GO:0047339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDP-hexose diphosphorylase activity
REACT:R-SSC-6787321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DERA cleaves dR5P to GA3P and CH3CHO (Sus scrofa)
REACT:R-HSA-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Homo sapiens)
RHEA:70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate = (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)
RHEA:43008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine = 2-aminoprop-2-enoate + H2O
RHEA:46700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate + GTP + H(+) = (R)-lipoyl-GMP + diphosphate
REACT:R-RNO-5655835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Rattus norvegicus)
REACT:R-HSA-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Homo sapiens)
REACT:R-BTA-2466106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BGN binds Collagen types I, VI, (IX) (Bos taurus)
RHEA:35301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-CoA + H(+) + NADPH => 3-hydroxyoctadecanoyl-CoA + NADP(+)
REACT:R-BTA-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Bos taurus)
RHEA:53073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:70603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxystyrene + H(+) + NADH = 4-ethylphenol + NAD(+)
REACT:R-DRE-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Danio rerio)
RHEA:60481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 UTP => c-di-UMP + 2 diphosphate
RHEA:68253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan(in) + Na(+)(in) => L-tryptophan(out) + Na(+)(out)
REACT:R-SSC-205319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of APS and p-KIT (Sus scrofa)
REACT:R-HSA-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Homo sapiens)
REACT:R-SSC-381487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP1 binds IGF forming IGF:IGFBP1 (Sus scrofa)
RHEA:60658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DRE-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Danio rerio)
REACT:R-BTA-2468287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)
REACT:R-CFA-212713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLC-gamma1 dissociates from EGFR (Canis familiaris)
REACT:R-GGA-8864029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Gallus gallus)
RHEA:20895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + phosphate <=> butanoyl phosphate + CoA
REACT:R-SSC-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Sus scrofa)
RHEA:42755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-HSA-110349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of UNG glycosylase by APEX1 at the AP site (Homo sapiens)
REACT:R-SSC-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)
REACT:R-DDI-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Dictyostelium discoideum)
REACT:R-CEL-9021357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCI phosphorylates ELF3 (Caenorhabditis elegans)
REACT:R-BTA-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Bos taurus)
GO:0033894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease P4"
GO:0033894	skos:prefLabel	"ribonuclease P4"
GO:0033894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease P4 activity
RHEA:25465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + longifolene
REACT:R-DRE-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Danio rerio)
REACT:R-HSA-1482939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PGP by PGS1 (Homo sapiens)
REACT:R-BTA-2046265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the keratan chain (Bos taurus)
REACT:R-GGA-9029690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-6 translocates to the nucleus (Gallus gallus)
REACT:R-MMU-374337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apelin receptor binds to apelin (Mus musculus)
RHEA:25933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylquinoline + A + H2O => 4-methylquinolin-2(1H)-one + AH2
GO:0043839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid A 1-phosphomethyltransferase activity
GO:0043839	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LmtA
GO:0043839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid A phosphomethyltransferase activity
GO:0043839	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lipid A methyltransferase
GO:0043839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid A phosphate methyltransferase activity
EC:3.4.22.66	skos:altLabel	"Norwalk virus processing peptidase"
EC:3.4.22.66	skos:altLabel	"norovirus virus processing peptidase"
EC:3.4.22.66	skos:altLabel	"Camberwell virus processing peptidase"
EC:3.4.22.66	skos:prefLabel	"calicivirin"
EC:3.4.22.66	skos:altLabel	"Southampton virus processing peptidase"
EC:3.4.22.66	skos:altLabel	"rabbit hemorrhagic disease virus 3C endopeptidase"
EC:3.4.22.66	skos:altLabel	"Chiba virus processing peptidase"
EC:3.4.22.66	skos:altLabel	"calicivirus 3C-like protease"
EC:3.4.22.66	skos:altLabel	"calicivirus trypsin-like cysteine protease"
EC:3.4.22.66	skos:altLabel	"calicivirus endopeptidase"
EC:3.4.22.66	skos:altLabel	"calicivirus TCP"
EC:3.4.22.66	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"calicivirin"
REACT:R-DRE-1606807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Danio rerio)
GO:0004795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-phospho-L-homoserine phospho-lyase (adding water)
GO:0004795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine synthase activity
GO:0004795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)
GO:0004795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine synthetase activity
EC:1.14.13.166	skos:prefLabel	"4-nitrocatechol 4-monooxygenase"
EC:1.14.13.166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-nitrocatechol 4-monooxygenase"
REACT:R-GGA-8852200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of LCK by PTPN22 (Gallus gallus)
RHEA:54541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]
REACT:R-DRE-2870221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-selectin binds E-selectin ligand (Danio rerio)
RHEA:57348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methyl-L-kynurenine + H2O = 3-hydroxy-4-methylanthranilate + H(+) + L-alanine
RHEA:57848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + scopoletin = CO2 + fraxetin + succinate
RHEA:57848	skos:prefLabel	"scopoletin 8-hydroxylase"
RHEA:57848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scopoletin 8-hydroxylase"
RHEA:68935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + octanoate <=> AMP + diphosphate + NADP(+) + octanal
RHEA:38194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone <=> 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:41225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-DRE-2730847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP2 by PLCG (Danio rerio)
REACT:R-GGA-8850326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds self-lipid-based antigen via CD1 (Gallus gallus)
RHEA:35022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine(in) <=> L-threonine(out)
RHEA:32941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-choline
RHEA:21583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate + H(+) <=> (R)-acetoin + CO2
REACT:R-HSA-9702508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT mutants bind type I TKIs (Homo sapiens)
REACT:R-CFA-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Canis familiaris)
REACT:R-DME-9773803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKBKB phosphorylates NF-kappa-B inhibitor  (Drosophila melanogaster)
REACT:R-DME-8951951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds EP300 (Drosophila melanogaster)
RHEA:35619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idarate = D-glucarate
RHEA:24869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine
RHEA:44811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-10 + CO2 + diphosphate
REACT:R-RNO-5685985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Rattus norvegicus)
REACT:R-RNO-5624954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INPP5E translocates to the primary cilium (Rattus norvegicus)
RHEA:31741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyisoflavone + S-adenosyl-L-methionine
REACT:R-SCE-3968414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Saccharomyces cerevisiae)
RHEA:11698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + staurosporine => 3'-demethylstaurosporine + S-adenosyl-L-methionine
REACT:R-MMU-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Mus musculus)
RHEA:24258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + kanamycin 3'-phosphate => ATP + kanamycin A
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein peptidase activity
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein-specific protease activity
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conjugating protein-specific protease activity
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin-like-protein-specific protease activity
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin-specific protease activity involved in negative regulation of ERAD pathway
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like hydrolase activity
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitinyl-like hydrolase activity
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein-specific isopeptidase activity
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin-like specific protease activity
GO:0019783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conjugating protein-specific isopeptidase activity
RHEA:22892	skos:prefLabel	"methylenetetrahydrofolate dehydrogenase (NAD(+))"
RHEA:22892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylenetetrahydrofolate dehydrogenase (NAD(+))"
RHEA:22892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH
REACT:R-HSA-1168839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 (PTPN6) binds JAK2 in the receptor complex (Homo sapiens)
RHEA:38366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoylglycerol + H2O <=> glycerol + H(+) + octadecanoate
RHEA:53345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20a) in tRNA + NADP(+) => H(+) + NADPH + uridine(20a) in tRNA
RHEA:30800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH
REACT:R-MMU-9638120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU4 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)
REACT:R-GGA-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Gallus gallus)
RHEA:13286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-cysteine + L-glutamate => ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate
REACT:R-SPO-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Schizosaccharomyces pombe)
RHEA:47671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-XTR-2730664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Xenopus tropicalis)
RHEA:47452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5Z)-tetradecadienoyl-CoA + H2O = (3S)-hydroxy-(5Z-tetradecenoyl)-CoA
REACT:R-SPO-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Schizosaccharomyces pombe)
REACT:R-HSA-9011289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZSWIM8 binds ROBO3.1 (Homo sapiens)
REACT:R-HSA-5661217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds zinc (Homo sapiens)
REACT:R-MMU-8932276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Mus musculus)
REACT:R-DME-8932355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades Ub-NFE2L2 (Drosophila melanogaster)
REACT:R-MMU-198613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates p21Cip1 and p27Kip1 (Mus musculus)
REACT:R-SSC-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Sus scrofa)
REACT:R-DRE-114352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of tBID by BCL-2 (Danio rerio)
REACT:R-RNO-2029459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Rattus norvegicus)
RHEA:38061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA
REACT:R-DRE-9686930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is cleaved by CASP8 (Danio rerio)
RHEA:70309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine => beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol
REACT:R-CFA-5205824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Canis familiaris)
REACT:R-CFA-5676917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Canis familiaris)
REACT:R-SSC-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Sus scrofa)
REACT:R-HSA-975185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)
RHEA:66234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + IC-asc-DeltaC7-CoA => IC-asc-C7-CoA + O2
RHEA:17091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-gluconate
REACT:R-MMU-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Mus musculus)
REACT:R-DRE-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Danio rerio)
RHEA:28869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + lactose(out) => H(+)(in) + lactose(in)
REACT:R-HSA-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
RHEA:25960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoin + NADP(+) = benzil + H(+) + NADPH
REACT:R-RNO-8948226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Rattus norvegicus)
GO:0000254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsterol oxidase activity
GO:0000254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-4 methylsterol oxidase activity
GO:0000254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylsterol hydroxylase activity
GO:0000254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylsterol monooxygenase activity
GO:0008124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pterin-4-alpha-carbinolamine dehydratase activity
GO:0008124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrobiopterin dehydratase activity
GO:0008124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4a-hydroxytetrahydrobiopterin hydro-lyase activity
GO:0008124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin dehydratase activity
GO:0008124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pterin-4a-carbinolamine dehydratase activity
GO:0008124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
GO:0008124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-alpha-hydroxy-tetrahydropterin dehydratase activity
GO:0008124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4alpha-hydroxy-tetrahydropterin dehydratase activity
GO:0008124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]
GO:0008124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pterin-4alpha-carbinolamine dehydratase activity
RHEA:32036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)
REACT:R-HSA-180709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of multimerized Rev with beta-importin (Homo sapiens)
RHEA:36254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + AMP + diphosphate
GO:0042934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	achromobactin transporter activity
GO:0042934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	achromobactin transmembrane transporter activity
REACT:R-RNO-158354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Rattus norvegicus)
RHEA:65025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) => dehydrocholate + H(+) + NADPH
REACT:R-DRE-391377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone receptor can bind LH (Danio rerio)
REACT:R-DME-389897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Drosophila melanogaster)
REACT:R-CFA-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Canis familiaris)
REACT:R-DRE-421007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of Ca impermeable AMPA receptors (Danio rerio)
REACT:R-CEL-114275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BAX at the mitochondrial membrane (Caenorhabditis elegans)
RHEA:23841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,3-dihydroxyphenyl)propanoate + O2 => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)
GO:0140831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine, sodium:proton antiporter activity
GO:0140831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-asparagine(out) + Na(+)(out) = H(+)(out) + L-asparagine(in) + Na(+)(in)
REACT:R-GGA-1306965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Gallus gallus)
REACT:R-GGA-2395302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysino-5-ketonorleucine cross-links (Gallus gallus)
GO:0046810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	host cell extracellular matrix binding
RHEA:40004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate => (Z)-biformene + diphosphate
REACT:R-HSA-159005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
RHEA:33440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + H2O + O2 => glyoxylate + H(+) + H2O2
RHEA:51900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine = acetate + spermidine
RHEA:36045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial => all-trans-8'-apo-beta-carotenal + O2
REACT:R-CEL-9640168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Caenorhabditis elegans)
RHEA:65072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = dauca-4,7-diene + diphosphate
REACT:R-GGA-388831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CD28 (Gallus gallus)
REACT:R-PFA-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Plasmodium falciparum)
RHEA:21481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-furoyl-CoA + A + H2O => 5-hydroxy-2-furoyl-CoA + AH2 + H(+)
RHEA:10314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => H(+) + NADH + O2 + terephthalate
REACT:R-XTR-9634169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 and NDC1 bind the Nup93 complex (Xenopus tropicalis)
GO:0043821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA:succinate CoA-transferase activity
GO:0043821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA succinate CoA-transferase activity
GO:0043821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA:succinate CoA transferase activity
REACT:R-MMU-975185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)
REACT:R-XTR-5691439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRISC complex deubiquitinates NLRP3 (Xenopus tropicalis)
REACT:R-DME-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Drosophila melanogaster)
RHEA:22056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + NAD(+) = H(+) + hexadecanal + NADH
RHEA:22056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hexadecanol dehydrogenase"
RHEA:22056	skos:prefLabel	"hexadecanol dehydrogenase"
REACT:R-GGA-8874204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3 (Gallus gallus)
EC:3.1.3.1	skos:altLabel	"phosphomonoesterase"
EC:3.1.3.1	skos:prefLabel	"alkaline phosphatase"
EC:3.1.3.1	skos:altLabel	"glycerophosphatase"
EC:3.1.3.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkaline phosphatase"
EC:3.1.3.1	skos:altLabel	"alkaline phosphomonoesterase"
REACT:R-SSC-2467809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESPL1 (Separase) cleaves centromeric cohesin (Sus scrofa)
REACT:R-RNO-976768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3b (Rattus norvegicus)
RHEA:44759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:42487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-sorbitol 6-phosphate(in) + L-histidyl-[protein]
RHEA:18039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-carbamoylputrescine + NH4(+) => agmatine + H2O
REACT:R-RNO-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Rattus norvegicus)
RHEA:70029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine => N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine
GO:0008773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP:[protein-PII] uridylyltransferase activity
GO:0008773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridyl removing enzyme
GO:0008773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PII uridylyl-transferase activity
GO:0008773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein-PII] uridylyltransferase activity
GO:0008773	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uridylyl removing enzyme activity
GO:0008773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-PII uridylyltransferase activity
GO:0008773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP:protein-PII uridylyltransferase activity
REACT:R-HSA-9759209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2 binds extracellular TCN2:RCbl (Homo sapiens)
REACT:R-HSA-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Homo sapiens)
REACT:R-GGA-399952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIMK-1 by PAK (Gallus gallus)
REACT:R-CEL-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Caenorhabditis elegans)
REACT:R-CFA-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)
REACT:R-DME-8849082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 stimulates RHOA GTPase activity (Drosophila melanogaster)
REACT:R-MMU-3000120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLIF binds RCbl (Mus musculus)
GO:0034521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthoic acid dioxygenase activity
RHEA:17001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"proclavaminate amidinohydrolase"
RHEA:17001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amidinoproclavaminate + H2O = proclavaminate + urea
RHEA:17001	skos:altLabel	"proclavaminate amidino hydrolase"
RHEA:17001	skos:altLabel	"PAH"
RHEA:17001	skos:altLabel	"proclavaminic acid amidino hydrolase"
RHEA:17001	skos:prefLabel	"proclavaminate amidinohydrolase"
REACT:R-CFA-5610767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Canis familiaris)
RHEA:15228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-alpha-D-glucose
RHEA:50547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin C2 <=> prostaglandin B2
REACT:R-XTR-8942101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 monoubiquitinates Histone H2B (Xenopus tropicalis)
REACT:R-HSA-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Homo sapiens)
GO:0103079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3'-methylthio)propylmalate synthase activity
RHEA:47389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tetradecanoate ester + H2O => an aliphatic alcohol + H(+) + tetradecanoate
REACT:R-DRE-4641129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is ubiquitinated by SMURF2 (Danio rerio)
REACT:R-MMU-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Mus musculus)
RHEA:36848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + L-threonyl-[protein] => AMP + FMN-L-threonyl-[protein] + H(+)
REACT:R-DME-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)
REACT:R-GGA-187020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of pro-beta-NGF is processed to mature beta-NGF (Gallus gallus)
REACT:R-HSA-388831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CD28 (Homo sapiens)
RHEA:60868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP
RHEA:16281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)
RHEA:16281	skos:prefLabel	"dihydrostreptomycin-6-phosphate 3'alpha-kinase"
RHEA:16281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrostreptomycin-6-phosphate 3'alpha-kinase"
REACT:R-HSA-912496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of meiotic holliday junction (Homo sapiens)
RHEA:28696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(in) => hydrogencarbonate(out)
REACT:R-BTA-418845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of caspase-3 (Bos taurus)
GO:0052671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeraniol phosphotransferase activity
GO:0052671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeraniol kinase activity
RHEA:37154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-BTA-2022063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Bos taurus)
REACT:R-DRE-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Danio rerio)
RHEA:37328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-methionyl-L-alanine(out) => ADP + H(+) + L-methionyl-L-alanine(in) + phosphate
RHEA:45954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-alpha-D-glucose
REACT:R-CFA-5654584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS bind to PPTN11 (Canis familiaris)
RHEA:27654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + H(+) + pyruvate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2
GO:0001010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
GO:0001010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription factor activity, sequence-specific DNA binding transcription factor recruiting
GO:0001010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence-specific DNA binding transcription factor recruiting transcription factor activity
GO:0001010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription factor activity, sequence-specific DNA-binding transcription factor recruiting
GO:0016150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation release factor activity, codon nonspecific
REACT:R-HSA-2424243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Homo sapiens)
REACT:R-HSA-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
RHEA:40875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2
REACT:R-CEL-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Caenorhabditis elegans)
REACT:R-DRE-1236955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Movement of clathrin coated vesicles into early endosome (Danio rerio)
REACT:R-SCE-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Saccharomyces cerevisiae)
REACT:R-MMU-379415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Mus musculus)
RHEA:30329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-RNO-3640861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 ubiquitinates ADP-ribosylated AXIN (Rattus norvegicus)
REACT:R-CFA-3245898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds correnoids in the circulation (Canis familiaris)
REACT:R-CEL-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Caenorhabditis elegans)
REACT:R-RNO-5218836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2beta binds alphaVbeta3 (Rattus norvegicus)
RHEA:69491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecan-1-ol <=> H2O2 + tetradecanal
REACT:R-XTR-9677917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA inhibitors bind MAOA:FAD (Xenopus tropicalis)
REACT:R-GGA-2028679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Gallus gallus)
REACT:R-MMU-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Mus musculus)
REACT:R-MMU-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Mus musculus)
RHEA:21885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trithionate => H(+) + sulfate + thiosulfate
REACT:R-CFA-112381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Canis familiaris)
RHEA:48525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GP1c + H2O => ganglioside GQ1c + N-acetylneuraminate
REACT:R-CEL-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Caenorhabditis elegans)
REACT:R-MMU-8931653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Mus musculus)
REACT:R-BTA-4641260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL1 is degraded by the proteasome (Bos taurus)
RHEA:44703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + FAD + H(+) <=> a (2E)-enoyl-CoA + FADH2
REACT:R-MMU-193792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Mus musculus)
REACT:R-HSA-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)
RHEA:14890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,7E,9E,14Z,17Z)-icosapentaenoate
RHEA:59757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine
REACT:R-SCE-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)
RHEA:50417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] => H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)
REACT:R-GGA-2328033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds latent TGF-beta (Gallus gallus)
REACT:R-HSA-9677585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Homo sapiens)
REACT:R-DRE-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Danio rerio)
REACT:R-SSC-2243926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of histidino-hydroxylysinonorleucine cross-links (Sus scrofa)
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-methylmalonyl-CoA-carboxytransferase synthetase activity
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmalonyl coenzyme A holotranscarboxylase synthetase activity
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	biotin-methylmalonyl-CoA-carboxyltransferase synthetase
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-transcarboxylase synthetase activity
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-methylmalonyl-CoA-carboxytransferase ligase activity
GO:0004079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-methylmalonyl-CoA-carboxyltransferase ligase activity
REACT:R-RNO-2327738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Rattus norvegicus)
RHEA:44128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9E)-octadecenoate
RHEA:44247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-GGA-74716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin binds the insulin receptor (Gallus gallus)
REACT:R-HSA-9683746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 3a forms a homotetramer (Homo sapiens)
REACT:R-RNO-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Rattus norvegicus)
REACT:R-RNO-933531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-IRF7:p-IRF7 to nucleus (Rattus norvegicus)
REACT:R-CEL-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)
RHEA:17566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + S-adenosyl-L-methionine => 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-8850992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated PTEN (Rattus norvegicus)
REACT:R-CFA-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Canis familiaris)
REACT:R-DRE-9008054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RAPL1 (Danio rerio)
RHEA:51954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-5686475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Bos taurus)
RHEA:70345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-L-tyrosine + NADPH => chloride + L-tyrosine + NADP(+)
RHEA:70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine
RHEA:19376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NADP(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADPH
REACT:R-SSC-72127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal B Complex (Sus scrofa)
RHEA:50103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + taurine <=> CoA + H(+) + N-dodecanoyl-taurine
RHEA:13862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + NAD(+) => D-xylono-1,5-lactone + H(+) + NADH
REACT:R-HSA-9757454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST translocates from cytosol to mitochondrial matrix of hepatocytes (Homo sapiens)
REACT:R-RNO-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Rattus norvegicus)
REACT:R-SSC-1112755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds IL6ST (Sus scrofa)
GO:0034084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steryl deacetylase activity
GO:0034084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol deacetylase activity
RHEA:53125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene => delta-carotene
RHEA:66000	skos:prefLabel	"[methyl-Co(III) glycine betaine-specific corrinoid protein]--tetrahydrofolate methyltransferase"
RHEA:66000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)
RHEA:66000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[methyl-Co(III) glycine betaine-specific corrinoid protein]--tetrahydrofolate methyltransferase"
RHEA:52437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA
RHEA:23311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + D-glucarate <=> 2-O-[(E)-sinapoyl]-D-glucarate + CoA
REACT:R-CFA-9024326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Canis familiaris)
REACT:R-RNO-420582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin-1 trans heterodimer interaction (Rattus norvegicus)
RHEA:42730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2791) in 21S rRNA
EC:1.4.99.-	skos:prefLabel	"With other acceptors"
EC:1.4.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
REACT:R-BTA-9706330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS6 (Bos taurus)
REACT:R-DME-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Drosophila melanogaster)
REACT:R-DRE-8952823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Danio rerio)
GO:0019727	skos:prefLabel	"mevaldate reductase"
GO:0019727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mevaldate reductase"
GO:0019727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH
GO:0019727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mevaldate reductase (NAD+) activity
REACT:R-BTA-8936214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCY2C trimer binds GUCA2A,B (Bos taurus)
RHEA:61171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP
REACT:R-DRE-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Danio rerio)
GO:0070330	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	estrogen synthetase activity
GO:0070330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatase activity
REACT:R-HSA-9727944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to EEF1A1 (Homo sapiens)
RHEA:33927	skos:altLabel	"6-hydroxy-3-succinoylpyridine hydroxylase"
RHEA:33927	skos:prefLabel	"6-hydroxy-3-succinoylpyridine 3-monooxygenase"
RHEA:33927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-hydroxy-3-succinoylpyridine 3-monooxygenase"
RHEA:33927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 = 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde
RHEA:30348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + IDP => ADP + ITP
RHEA:22994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + CO2 + NADH => 3-oxopropanoate + CoA + NAD(+)
REACT:R-CEL-5099899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD4 (Caenorhabditis elegans)
RHEA:64197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-lysine + H2O => a fatty acid + L-lysine
GO:0019863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binding
REACT:R-SSC-8847968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN binds FRK (Sus scrofa)
GO:0043796	skos:prefLabel	"D-glyceraldehyde dehydrogenase (NADP(+))"
GO:0043796	skos:altLabel	"glyceraldehyde dehydrogenase"
GO:0043796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde dehydrogenase (NADP) activity
GO:0043796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glyceraldehyde dehydrogenase (NADP(+))"
GO:0043796	skos:altLabel	"GADH"
GO:0043796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + H2O + NADP(+) = (R)-glycerate + 2 H(+) + NADPH
REACT:R-MMU-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)
REACT:R-XTR-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Xenopus tropicalis)
REACT:R-XTR-1977959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with EGFR (Xenopus tropicalis)
REACT:R-HSA-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Homo sapiens)
GO:0003991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglutamate phosphokinase activity
GO:0003991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:N-acetyl-L-glutamate 5-phosphotransferase activity
GO:0003991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylglutamate kinase activity
GO:0003991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglutamate phosphokinase activity
GO:0003991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglutamic 5-phosphotransferase activity
GO:0003991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglutamate kinase activity
GO:0003991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglutamate 5-phosphotransferase activity
RHEA:66797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:58510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O
GO:0030760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:pyridine N-methyltransferase activity
GO:0030760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridine N-methyltransferase activity
GO:0030760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridine methyltransferase activity
REACT:R-BTA-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Bos taurus)
REACT:R-DRE-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Danio rerio)
RHEA:51227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]
REACT:R-BTA-9686980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 recruits APC/C:Cdh1 complex to SKP2 (Bos taurus)
REACT:R-MMU-9009488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 binds CSF1 (Mus musculus)
REACT:R-DRE-1889981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Danio rerio)
RHEA:17899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-phenylethanol + AH2 => A + ethylbenzene + H2O
RHEA:66774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + uroporphyrin I(out) => ATP + H2O + uroporphyrin I(in)
RHEA:43610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate => agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O
RHEA:21109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + H(+) => 2-methylbutanal + CO2
REACT:R-BTA-5694417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Bos taurus)
REACT:R-MMU-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Mus musculus)
REACT:R-BTA-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)
REACT:R-HSA-374672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-heterodimerization of L1 and Axonin-1 (Homo sapiens)
REACT:R-MMU-192097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Mus musculus)
REACT:R-CFA-1433423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP-RO interacts with p-c-Kit complex (Canis familiaris)
REACT:R-CEL-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Caenorhabditis elegans)
REACT:R-DRE-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Danio rerio)
RHEA:41951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH
RHEA:38554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 <=> (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-SSC-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Sus scrofa)
RHEA:72097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine(in) + Na(+)(in) => (S)-carnitine(out) + Na(+)(out)
RHEA:16388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + hydroquinone + NADP(+)
REACT:R-BTA-350319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of vimentin at IDVD (259) (Bos taurus)
RHEA:68918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + butanal + diphosphate + NADP(+) => ATP + butanoate + H(+) + NADPH
REACT:R-SSC-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Sus scrofa)
REACT:R-PFA-111746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Plasmodium falciparum)
RHEA:68579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + xanthine(out) <=> ADP + H(+) + phosphate + xanthine(in)
RHEA:68670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate
REACT:R-HSA-9815529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs (Homo sapiens)
RHEA:71026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(in) + L-phenylalanine(out) <=> L-leucine(out) + L-phenylalanine(in)
REACT:R-BTA-192065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
RHEA:40763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Re + H2O = (20S)-ginsenoside Rg1 + L-rhamnopyranose
RHEA:40763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ginsenosidase type IV"
RHEA:40763	skos:prefLabel	"ginsenosidase type IV"
RHEA:17767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + H(+) => (2R)-3-phospho-glyceroyl phosphate
REACT:R-SSC-264689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Sus scrofa)
RHEA:53416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-amino-8-demethylriboflavin + S-adenosyl-L-methionine = 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine
RHEA:40990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDTA + 2 FMNH2 + 2 O2 <=> ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O
REACT:R-DRE-8951500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CANX from nonameric complex (Danio rerio)
RHEA:71113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(in) + S-methylmercury-L-cysteine(out) => L-phenylalanine(out) + S-methylmercury-L-cysteine(in)
REACT:R-CFA-374331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bradykinin receptors B1 and B2 bind to bradykinin (Canis familiaris)
RHEA:70972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-dopa + H2O + O2 => 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)
RHEA:34414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabigerolate + O2 <=> cannabidiolate + H2O2
RHEA:32459	skos:prefLabel	"uroporphyrinogen-III C-methyltransferase"
RHEA:32459	skos:altLabel	"uroporphyrinogen methyltransferase"
RHEA:32459	skos:altLabel	"adenosylmethionine-uroporphyrinogen III methyltransferase"
RHEA:32459	skos:altLabel	"uroporphyrin-III C-methyltransferase"
RHEA:32459	skos:altLabel	"uroporphyrinogen-III methyltransferase"
RHEA:32459	skos:altLabel	"uroporphyrinogen III methylase"
RHEA:32459	skos:altLabel	"urogen III methylase"
RHEA:32459	skos:altLabel	"SUMT"
RHEA:32459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine
RHEA:32459	skos:altLabel	"uroporphyrinogen-III methylase"
RHEA:32459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uroporphyrinogen-III C-methyltransferase"
RHEA:32459	skos:altLabel	"S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase"
RHEA:27776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine
REACT:R-BTA-6803523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Bos taurus)
REACT:R-CFA-1470009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs (Canis familiaris)
GO:0032427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMD binding
GO:0032427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc42/Rac interactive binding motif binding
GO:0032427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBD domain binding
GO:0032427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRIB motif binding
GO:0032427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P21-Rho-binding domain binding
REACT:R-CFA-9623384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-agonists bind ADRA1A,B,D (Canis familiaris)
REACT:R-CFA-5692764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 binds CCND3 (Canis familiaris)
RHEA:37944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O
RHEA:26205	skos:prefLabel	"4-nitrophenol 2-hydroxylase"
RHEA:26205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+)
RHEA:26205	skos:altLabel	"CYP2E1"
RHEA:26205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-nitrophenol 2-hydroxylase"
GO:0010437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10 (9', 10')-carotenoid-cleaving dioxygenase activity
RHEA:38387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)
REACT:R-RNO-2161917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15S-HpETE to LXA4/B4 (Rattus norvegicus)
REACT:R-SSC-4420153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds PLCG1 (Sus scrofa)
RHEA:49169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine
RHEA:48221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA => (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-MMU-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Mus musculus)
REACT:R-SSC-429567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Sus scrofa)
REACT:R-XTR-194121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-DRE-5620921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Danio rerio)
RHEA:22203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-aconitate <=> (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine
RHEA:10802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + xanthine => diphosphate + XMP
RHEA:18029	skos:altLabel	"carbamoyl-phosphate synthetase I"
RHEA:18029	skos:altLabel	"carbamoylphosphate synthetase (ammonia)"
RHEA:18029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carbamoyl-phosphate synthase (ammonia)"
RHEA:18029	skos:altLabel	"carbamoylphosphate synthase (ammonia)"
RHEA:18029	skos:altLabel	"CPS I"
RHEA:18029	skos:altLabel	"carbamoyl-phosphate synthetase (ammonia)"
RHEA:18029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate
RHEA:18029	skos:prefLabel	"carbamoyl-phosphate synthase (ammonia)"
RHEA:18029	skos:altLabel	"carbon-dioxide--ammonia ligase"
REACT:R-BTA-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Bos taurus)
RHEA:57323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]
REACT:R-CFA-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Canis familiaris)
GO:0018812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Homo sapiens)
GO:0018812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyacyl-CoA dehydratase activity
REACT:R-GGA-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Gallus gallus)
RHEA:59055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine + H(+) <=> cadaverine + CO2
REACT:R-RNO-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Rattus norvegicus)
REACT:R-XTR-4546386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO1 (Xenopus tropicalis)
REACT:R-DRE-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Danio rerio)
RHEA:54635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + tetradecanoyl-CoA <=> 2-hydroxytetradecanoyl-CoA + CO2 + succinate
RHEA:10619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-catechin + H2O + NADP(+) <=> (2R,3S,4S)-leucocyanidin + H(+) + NADPH
RHEA:18802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(cis-prenyl)n-diphosphate + isopentenyl diphosphate => (cis-prenyl)(n+1)-diphosphate + diphosphate
RHEA:49628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine
RHEA:25420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybenzoyl-CoA reductase"
RHEA:25420	skos:altLabel	"3-hydroxybenzoyl-CoA reductase (dearomatising)"
RHEA:25420	skos:prefLabel	"3-hydroxybenzoyl-CoA reductase"
RHEA:25420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O = 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate
REACT:R-SCE-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Saccharomyces cerevisiae)
RHEA:20936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O
RHEA:66624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
GO:0033826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity
GO:0033826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity
GO:0033826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xyloglucan 4beta-D-glucosyltransferase activity
GO:0033826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xyloglucan 4-glucosyltransferase activity
GO:0033826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity
GO:0033826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xyloglucan glucosyltransferase activity
REACT:R-HSA-391152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds PTK2B (Homo sapiens)
REACT:R-RNO-2584246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT1-GTP hydrolyses its bound GTP to GDP (Rattus norvegicus)
RHEA:52396	skos:prefLabel	"4-phospho-D-threonate 3-dehydrogenase"
RHEA:52396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-D-threonate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH
RHEA:52396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-phospho-D-threonate 3-dehydrogenase"
GO:0009916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alternative oxidase activity
REACT:R-RNO-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Rattus norvegicus)
RHEA:22491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(hydroxymethyl)glutathione <=> formaldehyde + glutathione
REACT:R-XTR-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Xenopus tropicalis)
REACT:R-CFA-5357845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is deubiquitinated (Canis familiaris)
RHEA:11782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose
REACT:R-DDI-5696564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP25 deubiquitinates DDX58 (Dictyostelium discoideum)
RHEA:45533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine
GO:0047188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylhydroxamic acyltransferase activity
GO:0047188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity
GO:0047188	skos:prefLabel	"aromatic-hydroxylamine O-acetyltransferase"
GO:0047188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-4-acetylaminobiphenyl = N-acetoxy-4-aminobiphenyl
GO:0047188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylhydroxamate acyltransferase activity
GO:0047188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylhydroxamic acid N,O-acetyltransferase activity
GO:0047188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aromatic hydroxylamine acetyltransferase activity
GO:0047188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic-hydroxylamine O-acetyltransferase activity
GO:0047188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity
GO:0047188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aromatic-hydroxylamine O-acetyltransferase"
GO:0047188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,O-acetyltransferase activity
GO:0050296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stipitatonate decarboxylase activity
GO:0050296	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	stipitatonate carboxy-lyase (decyclizing)
GO:0050296	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)
REACT:R-RNO-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Rattus norvegicus)
RHEA:22922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate => L-glutamine + scyllo-inosose
REACT:R-XTR-1602446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Xenopus tropicalis)
REACT:R-DRE-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Danio rerio)
RHEA:46610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-threonyl-[protein] => ATP + L-threonyl-[protein]
REACT:R-DDI-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Dictyostelium discoideum)
GO:0031757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edg-4 lysophosphatidic acid receptor binding
GO:0031757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA2 receptor binding
GO:0031757	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Edg-4 lysophosphatidic acid receptor ligand
RHEA:16425	skos:prefLabel	"formaldehyde dehydrogenase"
RHEA:16425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formaldehyde dehydrogenase"
RHEA:16425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH
RHEA:20153	skos:prefLabel	"L-arabinokinase"
RHEA:20153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate + H(+)
RHEA:20153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arabinokinase"
RHEA:68621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + H(+) + NADPH => 20beta-dihydrocortisone + NADP(+)
REACT:R-XTR-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)
RHEA:14882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) => asparagusate + H(+) + NADH
GO:0043756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AdoCbi hydrolase activity
GO:0043756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylcobinamide amidohydrolase activity
GO:0043756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CbiZ
GO:0043756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcobinamide hydrolase activity
GO:0043756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AdoCbi amidohydrolase activity
REACT:R-GGA-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Gallus gallus)
REACT:R-RNO-2213241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of nonameric complex (Rattus norvegicus)
GO:0043826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SOR
GO:0043826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur oxygenase reductase activity
GO:0043826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphur oxygenase reductase activity
REACT:R-HSA-1791164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SSR1 (Trap alpha) (Homo sapiens)
REACT:R-HSA-176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST trimers transfer GS from GSH to luminal substrates (Homo sapiens)
REACT:R-DME-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Drosophila melanogaster)
RHEA:68337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine sulfonate + H2O => (R)-pantetheine sulfonate + phosphate
REACT:R-RNO-9724745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds aprotinin (Rattus norvegicus)
GO:0042497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triacyl lipopeptide binding
GO:0042497	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bacterial triacyl lipoprotein binding
GO:0042497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triacylated lipopeptide binding
GO:0042497	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial triacyl lipopeptide binding
RHEA:37621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-HSA-9635804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF4 and phospho-ATF2 bind the DDIT3 promoter (Homo sapiens)
REACT:R-DDI-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Dictyostelium discoideum)
REACT:R-DME-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Drosophila melanogaster)
REACT:R-DME-8952062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 recruits HDAC4 to RUNX3 (Drosophila melanogaster)
RHEA:17322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + S-adenosyl-L-methionine => 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine
RHEA:53834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate => 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2
REACT:R-BTA-2485148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Bos taurus)
RHEA:48787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose 4-phosphate <=> D-erythrose 4-phosphate
REACT:R-CEL-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Caenorhabditis elegans)
REACT:R-RNO-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Rattus norvegicus)
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled vitamin B12 transmembrane transporter activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cobalamin porter activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cobalamin transporter activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalamin-transporting ATPase activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	vitamin B12-transporting ATPase activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B12 ABC transporter activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent cobalamin transmembrane transporter activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	vitamin B12 porter activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled cobalamin transmembrane transporter activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalamin ABC transporter
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent vitamin B12 transmembrane transporter activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type vitamin B12 transporter activity
GO:0015420	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	vitamin B12 transporter activity
REACT:R-DME-1592316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP1 (Drosophila melanogaster)
REACT:R-RNO-5218826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Rattus norvegicus)
RHEA:14238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine
RHEA:29421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + Na(+)(out) => H(+)(out) + Na(+)(in)
REACT:R-DDI-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Dictyostelium discoideum)
REACT:R-HSA-5229273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCN2:2,5DHBA binds Fe3+ (Homo sapiens)
REACT:R-SSC-8938300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vanin hydrolyses pantetheine to PanK, 2AET (Sus scrofa)
RHEA:12288	skos:altLabel	"Alpha-L-fucoside fucohydrolase"
RHEA:12288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucoside + H2O = an alcohol + L-fucose
RHEA:12288	skos:prefLabel	"alpha-L-fucosidase"
RHEA:12288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-L-fucosidase"
REACT:R-CFA-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Canis familiaris)
REACT:R-DME-77304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Drosophila melanogaster)
RHEA:13696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)
RHEA:70416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dihydroxyphenyl)acetyl-CoA + H2O => (3,5-dihydroxyphenyl)acetate + CoA + H(+)
RHEA:30168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate
REACT:R-HSA-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Homo sapiens)
REACT:R-CFA-2213205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type XII and XIV collagens associate with type I and type II fibrils. (Canis familiaris)
REACT:R-DDI-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Dictyostelium discoideum)
RHEA:29159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)
REACT:R-RNO-2213248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of antigen loaded MHC II molecules to surface (Rattus norvegicus)
REACT:R-BTA-9661397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)
REACT:R-GGA-9749590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates ALB (Gallus gallus)
REACT:R-HSA-9715357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crizotinib-resistant ALK mutants don't bind crizotinib (Homo sapiens)
REACT:R-CEL-9661723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)
REACT:R-DRE-5654622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)
GO:0047410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity
GO:0047410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formylmethionylaminoacyl-tRNA deformylase activity
REACT:R-RNO-2632521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Rattus norvegicus)
RHEA:67979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-neurosporene <=> beta-zeacarotene
RHEA:13514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + NAD(+) => H(+) + NADH + orotate
RHEA:22520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + H2O + O2 = all-trans-retinoate + H(+) + H2O2
REACT:R-DRE-5626953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds DENN/MADD (Danio rerio)
REACT:R-BTA-201472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Bos taurus)
REACT:R-DDI-1169403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 ligase with ISG15:E2 complex (Dictyostelium discoideum)
GO:0102368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin 30-monooxygenase activity
REACT:R-DDI-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Dictyostelium discoideum)
REACT:R-HSA-8869506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Homo sapiens)
REACT:R-SPO-69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk1 (Schizosaccharomyces pombe)
REACT:R-XTR-8964317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Xenopus tropicalis)
REACT:R-CFA-391158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP alpha binds CD47 (Canis familiaris)
RHEA:13932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O <=> putrescine + urea
GO:0017131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine-rich cytoplasmic polyadenylylation element binding
GO:0017131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U-rich CPE binding
GO:0017131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine-rich cytoplasmic polyadenylation element binding
REACT:R-MMU-5690080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP3,SAGA deubiquitinate Histone H2A,H2B (Mus musculus)
REACT:R-GGA-5362549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np traffics to the plasma membrane (Gallus gallus)
REACT:R-DME-266012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTD4 is converted to LTE4 by DPEP1/2 (Drosophila melanogaster)
REACT:R-DME-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)
RHEA:16848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H(+)
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MsrA
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide methionine sulfoxide reductase activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine S-oxide reductase (S-form oxidizing) activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine sulphoxide reductase A activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-methionine-(S)-S-oxide reductase activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-methionine-S-oxide reductase activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide Met(O) reductase activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-methionine (S)-S-oxide reductase activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine sulfoxide (protein) reductase activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methionine sulfoxide reductase activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methionine S-oxide reductase activity
GO:0008113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine sulfoxide reductase A activity
REACT:R-SCE-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Saccharomyces cerevisiae)
RHEA:38723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol
RHEA:10776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH
REACT:R-DRE-5653766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Danio rerio)
RHEA:22590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline + H2O => 4-aminobutanal
GO:0018737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ketocyclohexane-1-carboxyl-CoA hydrolase activity
REACT:R-SSC-1236958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of particulate antigens with dendritic cell receptors (Sus scrofa)
REACT:R-CEL-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Caenorhabditis elegans)
RHEA:39172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyeicosanoyl-CoA + NADP(+)
RHEA:65043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-3296301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCRL2 binds CCL19 (Rattus norvegicus)
REACT:R-SSC-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Sus scrofa)
REACT:R-DRE-444047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR3 binds carboxylates (Danio rerio)
REACT:R-XTR-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)
RHEA:44975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + hexanoyl-CoA <=> CoA + O-hexanoyl-(R)-carnitine
REACT:R-RNO-432195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Rattus norvegicus)
RHEA:14348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-tyrosine <=> CO2 + tyramine
REACT:R-HSA-9617972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO3 binds SOD2 gene promoter (Homo sapiens)
RHEA:37835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+)
RHEA:37835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aklavinone 12-hydroxylase"
RHEA:37835	skos:altLabel	"aklavinone 11-hydroxylase"
RHEA:37835	skos:prefLabel	"aklavinone 12-hydroxylase"
REACT:R-HSA-9727860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to UBE2I (Homo sapiens)
GO:0032550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine ribonucleoside binding
RHEA:57674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-8987080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Rattus norvegicus)
REACT:R-BTA-3928598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of p190RhoGEF to p-FAK (Bos taurus)
REACT:R-SSC-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Sus scrofa)
RHEA:53731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-muramate 6-phosphate <=> N-acetyl-D-muramate + phosphate
RHEA:39384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)
REACT:R-RNO-2404199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:IGF1R autophosphorylates (Rattus norvegicus)
RHEA:15914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine phosphate => ADP + thiamine diphosphate
REACT:R-HSA-5637766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)
REACT:R-HSA-2395320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 binds integrins (Homo sapiens)
REACT:R-SSC-8987043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22RA1 binds JAK1 (Sus scrofa)
RHEA:56830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5,6-tetrachlorohydroquinone + 2 glutathione => 2,3,6-trichlorohydroquinone + chloride + glutathione disulfide
REACT:R-MMU-1237081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Mus musculus)
RHEA:12082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxobutanoyl-[ACP] + CO2 + CoA => acetyl-CoA + H(+) + malonyl-[ACP]
REACT:R-SSC-8981657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds PTPRZ1 (Sus scrofa)
REACT:R-XTR-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Xenopus tropicalis)
RHEA:66329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine(out) => taurine(in)
RHEA:13839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-dihydroxyphthalate + H(+) + NADH => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)
REACT:R-BTA-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
REACT:R-GGA-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Gallus gallus)
REACT:R-MMU-5694433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 binds PREB (Mus musculus)
RHEA:25831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 <=> A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O
REACT:R-SSC-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Sus scrofa)
RHEA:34638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + pentalenolactone D
REACT:R-MMU-5671772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T38-PPP1R14A binds MLCP (Mus musculus)
REACT:R-HSA-374699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC5A binds NRAGE (Homo sapiens)
REACT:R-PFA-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Plasmodium falciparum)
REACT:R-RNO-3772430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNBIP1 binds beta-catenin (Rattus norvegicus)
RHEA:55191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyluridine(54) in tRNA + ATP + hydrogen sulfide <=> 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate
REACT:R-RNO-909722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-STAT2:p-STAT1 dimer (Rattus norvegicus)
REACT:R-SPO-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Schizosaccharomyces pombe)
GO:0097626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity L-arginine transmembrane transporter activity
GO:0097626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity L-arginine transmembrane transporter activity
RHEA:69132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine + H2O + O2 = 5-aminopentanal + H2O2 + NH4(+)
REACT:R-HSA-433089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT can transport taurolithocholate-3-sulphate (Homo sapiens)
REACT:R-HSA-8854051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL18 ubiquitinates FBXL7 (Homo sapiens)
RHEA:25608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O <=> 2-(3-methylsulfanyl)propylmalate + CoA + H(+)
REACT:R-DRE-2168886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemopexin binds Hemes (Danio rerio)
REACT:R-HSA-9018494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXA1 and GATA3 bind TFF genes (Homo sapiens)
RHEA:46249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-RNO-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Rattus norvegicus)
REACT:R-XTR-9727607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ binds sacubitrilat (Xenopus tropicalis)
REACT:R-SSC-9700156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK dimer binds IRS1 (Sus scrofa)
REACT:R-MMU-4086200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin matrix protein 1 binds integrin alphaVbeta3 (Mus musculus)
GO:0001848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement binding
GO:0018534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrilotriacetate dehydrogenase activity
RHEA:28908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) => 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)
REACT:R-HSA-9629149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves thymine glycol from damaged DNA (Homo sapiens)
REACT:R-HSA-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Homo sapiens)
GO:0031811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y receptor binding
GO:0031811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled nucleotide receptor binding
GO:0031811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metabotropic nucleotide receptor binding
GO:0031811	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metabotropic nucleotide receptor ligand
GO:0031811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled nucleotide receptor binding
RHEA:57946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 H2O + heme b => H(+) + H2O2 + harderoheme III
REACT:R-BTA-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Bos taurus)
REACT:R-CFA-212252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Canis familiaris)
REACT:R-HSA-380869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked dopamine loaded synaptic vesicle (Homo sapiens)
REACT:R-DRE-5634802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Danio rerio)
REACT:R-SSC-5653886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1 binds LALBA (Sus scrofa)
REACT:R-BTA-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Bos taurus)
REACT:R-BTA-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Bos taurus)
REACT:R-MMU-75187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)
REACT:R-HSA-1247999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. (Homo sapiens)
RHEA:40268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH
REACT:R-SSC-5668629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Sus scrofa)
EC:2.7.11.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Protein-serine/threonine kinases"
EC:2.7.11.-	skos:prefLabel	"Protein-serine/threonine kinases"
REACT:R-CFA-418856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 (Canis familiaris)
REACT:R-XTR-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Xenopus tropicalis)
RHEA:72516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + glutarate(in) => (R)-carnitine(in) + glutarate(out)
REACT:R-CEL-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Caenorhabditis elegans)
GO:0043899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thrH
GO:0043899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoserine:homoserine phosphotransferase activity
GO:0110068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosylglycerate phosphorylase activity
RHEA:63623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dodecanoate + holo-[ACP] <=> AMP + diphosphate + dodecanoyl-[ACP]
RHEA:58369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) => (2E,6Z)-nona-2,6-dienal + H(+) + NADPH
RHEA:15575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + melatonin + S-adenosyl-L-homocysteine => N-acetylserotonin + S-adenosyl-L-methionine
REACT:R-MMU-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Mus musculus)
REACT:R-CEL-2161999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Caenorhabditis elegans)
RHEA:65564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine
REACT:R-BTA-9024993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Bos taurus)
REACT:R-SSC-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Sus scrofa)
RHEA:29024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-fucose(in) => H(+)(out) + L-fucose(out)
REACT:R-RNO-9021050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 oligomer binds ESRs (Rattus norvegicus)
RHEA:51216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)
RHEA:68926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + hexanal + NADP(+) => ATP + H(+) + hexanoate + NADPH
REACT:R-PFA-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Plasmodium falciparum)
RHEA:32669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + methyl-coenzyme M => coenzyme M + methanethiol
REACT:R-HSA-4720497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALG12 does not add mannose to the N-glycan precursor (Homo sapiens)
REACT:R-SSC-9611721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1-agonists bind ADRB1 (Sus scrofa)
RHEA:12397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-D-galactose + H2O + 2 NADP(+) => dTDP-D-galacturonate + 3 H(+) + 2 NADPH
RHEA:70868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(out) + L-glutamine(in) + Na(+)(out) => L-alanine(in) + L-glutamine(out) + Na(+)(in)
REACT:R-DME-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Drosophila melanogaster)
RHEA:11472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-methyl-L-amino acid + H2O + O2 = an L-alpha-amino acid + formaldehyde + H2O2
RHEA:11472	skos:prefLabel	"N-methyl-L-amino-acid oxidase"
RHEA:11472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-methyl-L-amino-acid oxidase"
REACT:R-RNO-400204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds RXRA (Rattus norvegicus)
REACT:R-BTA-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Bos taurus)
REACT:R-DRE-169904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3G stimulates nucleotide exchange on Rap1 (Danio rerio)
REACT:R-RNO-174452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha on the C-strand of the telomere (Rattus norvegicus)
REACT:R-HSA-912408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Telomeres cluster at the nuclear membrane (Homo sapiens)
GO:0102802	skos:prefLabel	"thebaine 6-O-demethylase"
GO:0102802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thebaine 6-O-demethylase"
GO:0102802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + neopinone + succinate
GO:0102802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thebaine 6-O-demethylase activity
RHEA:44109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + heptanal + NAD(+) => 2 H(+) + heptanoate + NADH
REACT:R-CFA-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Canis familiaris)
REACT:R-RNO-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Rattus norvegicus)
RHEA:44117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosan-1-ol + hexadecanoyl-CoA => CoA + eicosanyl hexadecanoate
RHEA:44302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA
REACT:R-BTA-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Bos taurus)
REACT:R-DRE-9014074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin4 (Danio rerio)
GO:0030291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein serine/threonine kinase inhibitor activity
EC:3.4.21.113	skos:altLabel	"CSFV NS3 endopeptidase"
EC:3.4.21.113	skos:altLabel	"bovine viral diarrhea virus NS3 endopeptidase"
EC:3.4.21.113	skos:prefLabel	"pestivirus NS3 polyprotein peptidase"
EC:3.4.21.113	skos:altLabel	"classical swine fever virus NS3 endopeptidase"
EC:3.4.21.113	skos:altLabel	"border disease virus NS3 endopeptidase"
EC:3.4.21.113	skos:altLabel	"BDV NS3 endopeptidase"
EC:3.4.21.113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pestivirus NS3 polyprotein peptidase"
EC:3.4.21.113	skos:altLabel	"BVDV NS3 endopeptidase"
REACT:R-HSA-1912393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAML in complex with NICD1 recruits CDK8 (Homo sapiens)
REACT:R-RNO-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)
REACT:R-GGA-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Gallus gallus)
RHEA:64965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + 2 H2O => dUMP + 2 H(+) + 2 phosphate
REACT:R-DME-1602377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Drosophila melanogaster)
REACT:R-GGA-2730862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of LYN kinase (Gallus gallus)
RHEA:11651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol + H(+) + NADPH + O2 <=> 1,4-menthane-3,8-diol + H2O + NADP(+)
RHEA:63278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2
RHEA:62823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-SCE-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Saccharomyces cerevisiae)
GO:0022871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbose PTS transporter activity
GO:0022871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity
RHEA:52838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indoxyl + NAD(+) => H(+) + indole + NADH + O2
RHEA:17841	skos:altLabel	"UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase"
RHEA:17841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP
RHEA:17841	skos:altLabel	"Skp1-HyPro GlcNAc-transferase"
RHEA:17841	skos:prefLabel	"[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase"
RHEA:17841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase"
RHEA:10332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-acylglycerophosphocholine O-acyltransferase"
RHEA:10332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
RHEA:10332	skos:prefLabel	"2-acylglycerophosphocholine O-acyltransferase"
REACT:R-RNO-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Rattus norvegicus)
RHEA:38049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-CFA-77340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Canis familiaris)
REACT:R-CFA-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)
REACT:R-DME-6809720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM1:MTMR12 (Drosophila melanogaster)
REACT:R-RNO-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Rattus norvegicus)
REACT:R-RNO-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Rattus norvegicus)
REACT:R-RNO-1454822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP1,2,8,13, PRSS2 (Rattus norvegicus)
RHEA:54088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + H(+) + NADH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)
RHEA:59520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoyl-CoA + hydrogencarbonate = (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate
REACT:R-CFA-8848355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes retinyl palmitate (Canis familiaris)
REACT:R-DRE-877198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates membrane pores that include pannexin-1 (Danio rerio)
REACT:R-SSC-4641205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPO:LGR binds ZNRF3 (Sus scrofa)
RHEA:43093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2479) in 23S rRNA => 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Homo sapiens)
REACT:R-BTA-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)
REACT:R-RNO-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Rattus norvegicus)
GO:0050616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secologanin synthase activity
GO:0050616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	loganin:oxygen oxidoreductase (ring-cleaving)
REACT:R-XTR-8854759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D14 binds RAB11 and ULK1 (Xenopus tropicalis)
RHEA:39437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH
GO:0070976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Toll-Interleukin receptor domain binding
GO:0070976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIR domain binding
RHEA:35703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-hydroxyversicolorone + H(+) + NADPH + O2 = (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)
REACT:R-HSA-2395364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP4 binds TGF-Beta-1 (Homo sapiens)
RHEA:59957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkanimidothioate => a nitrile + sulfate + sulfur
RHEA:70695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + glycine(out) + 3 Na(+)(out) = chloride(in) + glycine(in) + 3 Na(+)(in)
RHEA:28220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypochlorous acid => chloride + H(+) + H2O2
REACT:R-MMU-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
RHEA:51896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine = acetate + spermine
REACT:R-SSC-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Sus scrofa)
REACT:R-RNO-5693356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEMIP hydrolyses HA (Rattus norvegicus)
REACT:R-RNO-6784598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPPA(124-151) binds NPR1 (Rattus norvegicus)
RHEA:56613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + NAD(+) => H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]
RHEA:69902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + thymidine(out) <=> 2 Na(+)(in) + thymidine(in)
REACT:R-SSC-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Sus scrofa)
RHEA:54083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine
RHEA:70028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine
RHEA:53909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]
REACT:R-BTA-76453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A6 (Bos taurus)
REACT:R-SSC-2213248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of antigen loaded MHC II molecules to surface (Sus scrofa)
REACT:R-GGA-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Gallus gallus)
REACT:R-SSC-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Sus scrofa)
REACT:R-SPO-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Schizosaccharomyces pombe)
RHEA:42736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (guanine(1207)-N(2))-methyltransferase"
RHEA:42736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:42736	skos:altLabel	"m(2)G1207 methyltransferase"
RHEA:42736	skos:prefLabel	"16S rRNA (guanine(1207)-N(2))-methyltransferase"
GO:0046624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid transporter activity
GO:0046624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Homo sapiens)
RHEA:30622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + all-trans-zeta-carotene <=> 2 AH2 + all-trans-lycopene
REACT:R-CFA-433104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACT co-transports trivalent citrate and a sodium ion (Canis familiaris)
REACT:R-BTA-1250346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Bos taurus)
REACT:R-DRE-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Danio rerio)
REACT:R-CEL-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Caenorhabditis elegans)
REACT:R-MMU-5693584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)
REACT:R-CFA-8983384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Canis familiaris)
REACT:R-MMU-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Mus musculus)
REACT:R-DME-72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of eIF4E from the inactive eIF4E:4E-BP complex  (Drosophila melanogaster)
RHEA:68200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoylglycerol + hexadecanoyl-CoA = 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA
RHEA:12364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside
RHEA:12364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribosyldihydronicotinamide dehydrogenase (quinone)"
RHEA:12364	skos:altLabel	"NQO2"
RHEA:12364	skos:altLabel	"NRH:quinone oxidoreductase 2"
RHEA:12364	skos:prefLabel	"ribosyldihydronicotinamide dehydrogenase (quinone)"
RHEA:12364	skos:altLabel	"N-ribosyldihydronicotinamide dehydrogenase (quinone)"
RHEA:12364	skos:altLabel	"QR2"
RHEA:12364	skos:altLabel	"quinone reductase 2"
REACT:R-DRE-5678313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Danio rerio)
RHEA:25722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-trihomomethionine <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O
REACT:R-RNO-380927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK phosphorylates TSC1:TSC2 (Rattus norvegicus)
REACT:R-XTR-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)
REACT:R-DME-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Drosophila melanogaster)
GO:0140867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity
GO:0140867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E18 specific)
GO:0140867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone H2B-E18 glutamate ADP-ribosyltransferase activity
RHEA:62360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-N(5)-peroxide + uracil = (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)
REACT:R-DRE-977359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to membrane-associated Factor H:C3b (Danio rerio)
REACT:R-MMU-163099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alignment Of The RNA Template On The Telomeric Chromosome End (Mus musculus)
RHEA:66615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA <=> methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]
REACT:R-HSA-9701524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated downstream of active ALK (Homo sapiens)
REACT:R-RNO-381461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasmin proteolyzes IGF:IGFBP-3:ALS (Rattus norvegicus)
REACT:R-RNO-6788855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3KRP phosphorylates PsiAm, RibAm (Rattus norvegicus)
REACT:R-DRE-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Danio rerio)
RHEA:71417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out) => 3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in)
RHEA:67115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-GGA-388503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxytocin receptor bind oxytocin (Gallus gallus)
REACT:R-XTR-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Xenopus tropicalis)
REACT:R-RNO-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Rattus norvegicus)
REACT:R-XTR-1604741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP14 (MT1-MMP) (Xenopus tropicalis)
REACT:R-DRE-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Danio rerio)
RHEA:41957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-CMP + H2O => cytidine 2'-phosphate + H(+)
REACT:R-GGA-1112703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 is phosphorylated (Gallus gallus)
EC:3.1.26.4	skos:prefLabel	"ribonuclease H"
EC:3.1.26.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease H"
EC:3.1.26.4	skos:altLabel	"endoribonuclease H"
EC:3.1.26.4	skos:altLabel	"RNase H"
RHEA:43110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide => 2 Fe(III)-[cytochrome c] + H2O + N2
RHEA:10911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate
RHEA:29225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + menaquinol-8 => menaquinone-8 + sn-glycerol 3-phosphate
RHEA:21245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine => an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine
RHEA:48882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + CO2 => a quinone + CO + H2O
RHEA:34474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADH
REACT:R-RNO-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Rattus norvegicus)
REACT:R-DRE-349404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Danio rerio)
RHEA:60300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-SSC-1295613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds GRB2 (Sus scrofa)
REACT:R-SSC-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Sus scrofa)
REACT:R-HSA-8955822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SOCS4 gene (Homo sapiens)
EC:1.1.1.367	skos:prefLabel	"UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase"
EC:1.1.1.367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase"
RHEA:13608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + O2 <=> 2 H2O + 2 L-dehydroascorbate
RHEA:61286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+) => H2O + L-cystine + O2
RHEA:54126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + excited coelenteramide h monoanion + H(+) => coelenterazine h dioxetanone
REACT:R-BTA-8874079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated MET (Bos taurus)
REACT:R-BTA-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Bos taurus)
GO:0102677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesterol,NADPH:oxygen oxidoreductase activity
REACT:R-BTA-1971482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Bos taurus)
RHEA:33074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate <=> 2-deoxy-L-scyllo-inosose + phosphate
GO:0015492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine:hydrogen symporter activity
GO:0015492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine:proton symporter activity
REACT:R-CFA-6814683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Canis familiaris)
REACT:R-HSA-111919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates CREB1 (Homo sapiens)
RHEA:36871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA
REACT:R-XTR-8954262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Xenopus tropicalis)
REACT:R-XTR-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Xenopus tropicalis)
GO:0030611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate reductase activity
REACT:R-RNO-433131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC1 co-transports dicarboxylic acids and a sodium ion (Rattus norvegicus)
REACT:R-CFA-9009541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds to TFF1 gene promoter (Canis familiaris)
REACT:R-SCE-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Saccharomyces cerevisiae)
REACT:R-HSA-5228407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetX HC:LC binds target cell-surface gangliosides (Homo sapiens)
REACT:R-CEL-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Caenorhabditis elegans)
GO:1901514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipo-chitin oligosaccharide transmembrane-transporting ATPase activity
GO:1901514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity
REACT:R-CFA-2046285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The keratan chain can be capped by N-acetylneuraminic acid (Canis familiaris)
RHEA:65033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a quinone + protoporphyrinogen IX => 3 a quinol + protoporphyrin IX
REACT:R-DRE-8848247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD4,5 bind MCFA-CoA and LCFA-CoA (Danio rerio)
REACT:R-XTR-2993763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Xenopus tropicalis)
RHEA:57417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-asparaginyl-[protein] => L-aspartyl-[protein] + NH4(+)
REACT:R-DRE-9011543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCA binds PDK2 (Danio rerio)
GO:0005461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucuronic acid transmembrane transporter activity
RHEA:13447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate + cysteamine => (R)-pantetheine + H2O
RHEA:22299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate <=> (1R,2R,3R)-prephytoene diphosphate + diphosphate
REACT:R-SSC-2022399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Sus scrofa)
REACT:R-HSA-1855161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 transports from the nucleus to the cytosol (Homo sapiens)
RHEA:27739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + guanine
RHEA:27536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:41038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA
REACT:R-RNO-8940388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPLD1 hydrolyses GPI-anchors from proteins (Rattus norvegicus)
REACT:R-DME-9757686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDL (Drosophila melanogaster)
REACT:R-DRE-77263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Danio rerio)
REACT:R-SSC-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Sus scrofa)
REACT:R-GGA-4641129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is ubiquitinated by SMURF2 (Gallus gallus)
REACT:R-HSA-4093329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SDCBP (Homo sapiens)
REACT:R-SSC-8849082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 stimulates RHOA GTPase activity (Sus scrofa)
REACT:R-HSA-514604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Homo sapiens)
REACT:R-SPO-3215385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Schizosaccharomyces pombe)
EC:3.2.1.156	skos:prefLabel	"oligosaccharide reducing-end xylanase"
EC:3.2.1.156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligosaccharide reducing-end xylanase"
EC:3.2.1.156	skos:altLabel	"Rex"
EC:3.2.1.156	skos:altLabel	"reducing end xylose-releasing exo-oligoxylanase"
RHEA:46968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydroisopentenyldehydrorhodopin = AH2 + isopentenyldehydrorhodopin
RHEA:45404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-CEL-433104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACT co-transports trivalent citrate and a sodium ion (Caenorhabditis elegans)
REACT:R-BTA-9033520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves TYSND1 (Bos taurus)
RHEA:51780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlormethylbutanophenone + dimethylallyl diphosphate = deoxyadlupulone + diphosphate
REACT:R-CFA-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Canis familiaris)
RHEA:16626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hydrogen sulfide => CoA + thioacetate
REACT:R-BTA-8953461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Bos taurus)
REACT:R-MMU-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Mus musculus)
REACT:R-BTA-5690196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates RNF128 (Bos taurus)
REACT:R-RNO-8956050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Rattus norvegicus)
RHEA:17488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
REACT:R-DRE-917811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3-like proteins reduce Fe3+ to Fe2+ (Danio rerio)
REACT:R-SSC-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Sus scrofa)
REACT:R-GGA-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Gallus gallus)
REACT:R-XTR-749454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gi complex dissociates (Xenopus tropicalis)
GO:0030945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine phosphatase activity, via thiol-phosphate intermediate
REACT:R-GGA-5334854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAR:RXR binds SUMO-CRABP2:atRA (Gallus gallus)
REACT:R-CFA-4332356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK2 binds MAP3K7 (Canis familiaris)
REACT:R-MMU-975097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)
REACT:R-XTR-8875817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates STAT3 (Xenopus tropicalis)
RHEA:17959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propynoate => 3-oxopropanoate
REACT:R-DME-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Drosophila melanogaster)
REACT:R-GGA-5228523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates MDM2 with SUMO1 (Gallus gallus)
REACT:R-RNO-8853755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)
RHEA:67184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine = (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate
REACT:R-XTR-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Xenopus tropicalis)
REACT:R-DRE-2301205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 monomethylates histone H4 (Danio rerio)
RHEA:33869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + N-carbamoyl-2-oxoglycine => (S)-2-ureidoglycine + glyoxylate
GO:0102919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dimethylbenzimidazole synthase activity
GO:0102919	skos:prefLabel	"aerobic 5,6-dimethylbenzimidazole synthase"
GO:0102919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)
GO:0102919	skos:altLabel	"flavin reductase"
GO:0102919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aerobic 5,6-dimethylbenzimidazole synthase"
REACT:R-HSA-8870686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL2L11 (BIM) gene expression (Homo sapiens)
REACT:R-DME-1433418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Drosophila melanogaster)
REACT:R-MMU-1461995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-defensin alpha 5 is stored in Paneth cell granules (Mus musculus)
REACT:R-CEL-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Caenorhabditis elegans)
REACT:R-RNO-192341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)
REACT:R-DDI-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Dictyostelium discoideum)
REACT:R-MMU-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Mus musculus)
RHEA:29058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + 2 H(+)(in) + H2 <=> a ubiquinol + 2 H(+)(out)
REACT:R-DRE-5686304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Danio rerio)
REACT:R-MMU-9645414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Mus musculus)
EC:1.14.14.50	skos:prefLabel	"tabersonine 3-oxygenase"
EC:1.14.14.50	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tabersonine 3-oxygenase"
EC:1.14.14.50	skos:altLabel	"T3O"
EC:1.14.14.50	skos:altLabel	"CYP71D1V2"
RHEA:63043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lovastatin <=> H(+) + lovastatin carboxylate
RHEA:71221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + nitrate(in) => 2 Na(+)(out) + nitrate(out)
RHEA:14075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-3-hydroxybutanoate + CO2 => 3-hydroxy-L-glutamate + H(+)
REACT:R-HSA-8985104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAS2 produces oligoadenylates (Homo sapiens)
REACT:R-XTR-8987132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Xenopus tropicalis)
REACT:R-RNO-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Rattus norvegicus)
RHEA:22175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + UDP-alpha-D-glucose <=> H(+) + sucrose 6(F)-phosphate + UDP
RHEA:13380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + ATP <=> ADP + alpha-D-glucose 1,6-bisphosphate + H(+)
REACT:R-RNO-2533950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP14, TMPRSS6 (Rattus norvegicus)
RHEA:51473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosanoylsphinganine
RHEA:10617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-catechin + H2O + NADP(+) => (2R,3S,4S)-leucocyanidin + H(+) + NADPH
RHEA:36813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + GDP-N-acetyl-alpha-D-perosamine + H(+) => acetyl-CoA + GDP-alpha-D-perosamine
REACT:R-GGA-9009536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX5 binds ESR1:estrogen:TFF1 gene promoter (Gallus gallus)
REACT:R-MMU-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Mus musculus)
RHEA:25822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + H2O2 + propane-1,3-diamine => H2O + O2 + spermidine
REACT:R-CEL-9647746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 trimerizes (Caenorhabditis elegans)
REACT:R-SSC-936563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of DDX58 (Sus scrofa)
RHEA:66914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenanthramide B + H(+) + S-adenosyl-L-homocysteine => avenanthramide C + S-adenosyl-L-methionine
REACT:R-PFA-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Plasmodium falciparum)
REACT:R-HSA-6787321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DERA cleaves dR5P to GA3P and CH3CHO (Homo sapiens)
RHEA:53478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol
RHEA:35015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin(in) = riboflavin(out)
REACT:R-MMU-5666104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Mus musculus)
REACT:R-HSA-374686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 interaction with Integrins (Homo sapiens)
REACT:R-DDI-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Dictyostelium discoideum)
RHEA:33669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) => H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2
REACT:R-GGA-2201338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds TICAM1:activated TLR4 complex (Gallus gallus)
REACT:R-XTR-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Xenopus tropicalis)
RHEA:13096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP
REACT:R-SCE-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Saccharomyces cerevisiae)
REACT:R-DME-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Drosophila melanogaster)
REACT:R-HSA-5651971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC34A3 does not cotransport Pi, 2Na+ (Homo sapiens)
REACT:R-GGA-2132201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsonization with C3b or C4b (Gallus gallus)
REACT:R-HSA-444879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)
REACT:R-GGA-5654623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS3 (Gallus gallus)
EC:3.4.16.-	skos:prefLabel	"Serine-type carboxypeptidases"
EC:3.4.16.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Serine-type carboxypeptidases"
RHEA:54714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine
REACT:R-HSA-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Homo sapiens)
REACT:R-BTA-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Bos taurus)
REACT:R-BTA-9625813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P binds S1PR3 in response to E2 stimulation (Bos taurus)
REACT:R-RNO-5668520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26Sproteasome degrades K48polyUb-NIK (Rattus norvegicus)
RHEA:46057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DDI-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Dictyostelium discoideum)
RHEA:44629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dihydroanticapsin + NAD(+) => H(+) + L-anticapsin + NADH
REACT:R-SPO-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Schizosaccharomyces pombe)
GO:0005056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tiggrin receptor activity
GO:0140314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium ion sequestering activity
RHEA:66043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:66253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + IC-asc-C7 => AMP + diphosphate + IC-asc-C7-CoA
RHEA:26308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminophenol + O2 <=> 2-aminomuconate 6-semialdehyde
RHEA:61348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H(+) + phosphate
GO:0017044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melanocyte stimulating hormone activity
GO:0017044	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-melanocyte stimulating hormone activity
GO:0017044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melanocyte-stimulating hormone activity
GO:0017044	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-melanophore stimulating hormone activity
REACT:R-CFA-202717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of CEACAMs (Canis familiaris)
REACT:R-GGA-8987202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)
RHEA:30626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-neurosporene <=> AH2 + all-trans-lycopene
RHEA:39433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA
REACT:R-HSA-9021851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds CREB1 gene promoter (Homo sapiens)
GO:0017051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinol dehydratase activity
GO:0050156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl-CoA:L-ornithine N-benzoyltransferase activity
GO:0050156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine N-acyltransferase activity
GO:0050156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine N-benzoyltransferase activity
REACT:R-SSC-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Sus scrofa)
REACT:R-CEL-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Caenorhabditis elegans)
RHEA:31897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-humulene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:21076	skos:altLabel	"pyrimidine deoxyribonucleoside 2'-hydroxylase"
RHEA:21076	skos:altLabel	"deoxyuridine 2'-hydroxylase"
RHEA:21076	skos:prefLabel	"pyrimidine-deoxynucleoside 2'-dioxygenase"
RHEA:21076	skos:altLabel	"thymidine 2-oxoglutarate dioxygenase"
RHEA:21076	skos:altLabel	"thymidine 2'-hydroxylase"
RHEA:21076	skos:altLabel	"thymidine dioxygenase"
RHEA:21076	skos:altLabel	"thymidine 2'-dioxygenase"
RHEA:21076	skos:altLabel	"deoxyuridine 2'-dioxygenase"
RHEA:21076	skos:altLabel	"pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase"
RHEA:21076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrimidine-deoxynucleoside 2'-dioxygenase"
RHEA:21076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine
RHEA:59001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + propanal => H(+) + H2O2 + propanoate
REACT:R-GGA-5212679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3A binds Me2sR4-HIST1H4 (Gallus gallus)
REACT:R-RNO-446648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Rattus norvegicus)
REACT:R-SCE-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Saccharomyces cerevisiae)
RHEA:32343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-thujan-3-ol + NAD(+) = (+)-thujan-3-one + H(+) + NADH
REACT:R-CFA-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Canis familiaris)
REACT:R-CFA-205238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 interacts with p-KIT (Canis familiaris)
RHEA:47807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Homo sapiens)
RHEA:69835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + H2O => dAMP + diphosphate + H(+)
REACT:R-DRE-432688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Danio rerio)
REACT:R-SSC-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Sus scrofa)
RHEA:53546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-2160851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAS1,2,3 mediate the polymerisation of HA (Bos taurus)
REACT:R-CFA-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Canis familiaris)
REACT:R-RNO-1606564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Rattus norvegicus)
REACT:R-SCE-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Saccharomyces cerevisiae)
RHEA:19698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate
REACT:R-CFA-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Canis familiaris)
RHEA:32828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + methionine(out) => ADP + H(+) + methionine(in) + phosphate
GO:0033286	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ectoine transmembrane transporter activity
GO:0033286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-ectoine(out) = ADP + H(+) + L-ectoine(in) + phosphate
GO:0033286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ectoine-transporting ATPase activity
GO:0033286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled ectoine transmembrane transporter activity
GO:0033286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent ectoine transmembrane transporter activity
RHEA:42667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-arabinopyanose + NADP(+) <=> H(+) + L-arabinono-1,4-lactone + NADPH
RHEA:23625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in tRNA + NADP(+) => a uridine in tRNA + H(+) + NADPH
REACT:R-CEL-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Caenorhabditis elegans)
RHEA:31504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate => 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate
REACT:R-SSC-1606839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Steryl sulfatase hydrolyses sulfate from steroid sulfates (Sus scrofa)
RHEA:45648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-CFA-5623519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP and RAB8A bind to the ciliary targeting complex (Canis familiaris)
REACT:R-SSC-5693564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with RAD52:DNA double-strand break ends (Sus scrofa)
RHEA:24713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose
REACT:R-CFA-420243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHRH receptor binds GHRH (Canis familiaris)
REACT:R-RNO-9024872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 17(S)-Hp-DHA to PDX (Rattus norvegicus)
RHEA:56377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)
GO:0001734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA (N6-adenosine)-methyltransferase activity
GO:0001734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internal Methylation of mRNA (Homo sapiens)
RHEA:56018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)
RHEA:31773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O
RHEA:61598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbD protein]-disulfide + [thioredoxin]-dithiol => [DsbD protein]-dithiol + [thioredoxin]-disulfide
RHEA:25524	skos:altLabel	"syn-CPP synthase"
RHEA:25524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"syn-copalyl-diphosphate synthase"
RHEA:25524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = 9alpha-copalyl diphosphate
RHEA:25524	skos:prefLabel	"syn-copalyl-diphosphate synthase"
RHEA:25524	skos:altLabel	"syn-copalyl diphosphate synthase"
REACT:R-DRE-173745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3(H2O)-bound Factor B (Danio rerio)
RHEA:40765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg1 + L-rhamnopyranose => (20S)-ginsenoside Re + H2O
REACT:R-SSC-9021306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds and inactivates C1r, C1s (Sus scrofa)
RHEA:50390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5a,11a-dehydrooxytetracycline + H2O + NADP(+) => 5a,11a-dehydrotetracycline + H(+) + NADPH + O2
REACT:R-HSA-9008052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10(?-152) binds IL1RAPL1 (Homo sapiens)
RHEA:29348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + orotate(in) => 2 H(+)(out) + orotate(out)
REACT:R-CFA-2428930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Canis familiaris)
RHEA:13877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde
RHEA:16728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phosphatidylglycerol phosphate + H2O <=> a phosphatidylglycerol + phosphate
REACT:R-DME-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Drosophila melanogaster)
REACT:R-DRE-981809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Danio rerio)
RHEA:48687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine
REACT:R-HSA-5218826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Homo sapiens)
REACT:R-SPO-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Schizosaccharomyces pombe)
REACT:R-CFA-9627056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procaspase 9 forms dimer (Canis familiaris)
RHEA:66167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + serotonin <=> CoA + H(+) + N-butanoylserotonin
REACT:R-GGA-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Gallus gallus)
EC:6.3.1.9	skos:altLabel	"TSR synthetase"
EC:6.3.1.9	skos:prefLabel	"trypanothione synthase"
EC:6.3.1.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trypanothione synthase"
GO:0010844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA binding, recombination hotspot
GO:0010844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	recombination hotspot binding
EC:2.5.1.151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkylcobalamin dealkylase"
EC:2.5.1.151	skos:altLabel	"alkylcobalamin reductase"
EC:2.5.1.151	skos:prefLabel	"alkylcobalamin dealkylase"
RHEA:18395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-3-oxopropanoate + L-alanine => (R)-3-amino-2-methylpropanoate + pyruvate
RHEA:32221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-carotene => all-trans-lycopene
REACT:R-HSA-9617838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
REACT:R-BTA-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Bos taurus)
REACT:R-CEL-4085347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO1 (Caenorhabditis elegans)
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced-riboflavin:NADP+ oxidoreductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent FMN reductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH dehydrogenase (riboflavin) activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin reductase (NADPH) activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:riboflavin oxidoreductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMN reductase (NADPH) activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	riboflavin mononucleotide reductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	riboflavine mononucleotide reductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin reductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-specific FMN reductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2 dehydrogenase (riboflavin)
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-riboflavin reductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2:riboflavin oxidoreductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH-riboflavin oxidoreductase activity
GO:0042602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-FMN reductase activity
GO:0004583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
REACT:R-GGA-8938431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 and BTN1A1 binds periplakin (PPL) (Gallus gallus)
REACT:R-RNO-420580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:PVRL3 trans heterodimer formation (Rattus norvegicus)
RHEA:60330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine
REACT:R-DRE-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
GO:0005328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/neurotransmitter symporter activity
GO:0005328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter:sodium symporter activity
REACT:R-BTA-8856189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF8 binds TNFRSF8 (Bos taurus)
RHEA:61296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-alpha-D-ribose 1-phosphate = 5-deoxy-D-ribulose 1-phosphate
RHEA:54849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexan-3-one + NADPH + O2 => H2O + NADP(+) + propyl propanoate
RHEA:12440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NAD(+) = 2-oxoglutarate + H(+) + L-lysine + NADH
RHEA:12440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"saccharopine dehydrogenase (NAD(+), L-lysine-forming)"
RHEA:12440	skos:altLabel	"lysine-2-oxoglutarate reductase"
RHEA:12440	skos:prefLabel	"saccharopine dehydrogenase (NAD(+), L-lysine-forming)"
REACT:R-DME-451283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kainate receptor binds glutamate (Drosophila melanogaster)
REACT:R-SCE-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Saccharomyces cerevisiae)
RHEA:60152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-L-glutamyl-[protein] + H2O = L-glutamate + L-glutamyl-[protein]
RHEA:28637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-5-epi-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:18162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CoA
REACT:R-DRE-5635868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-GLI is degraded by the proteasome (Danio rerio)
REACT:R-XTR-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Xenopus tropicalis)
REACT:R-CEL-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Caenorhabditis elegans)
RHEA:51094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-5635741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Homo sapiens)
REACT:R-SSC-9705713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 dehydrogenates TEST to DHTEST (Sus scrofa)
REACT:R-GGA-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Gallus gallus)
REACT:R-SSC-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Sus scrofa)
RHEA:27628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate
REACT:R-CFA-8847977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRK phosphorylates PTEN (Canis familiaris)
RHEA:22763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cypridina luciferin + O2 <=> CO2 + hnu + oxidized Cypridina luciferin
REACT:R-CEL-1306957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
EC:3.4.23.31	skos:prefLabel	"scytalidopepsin A"
EC:3.4.23.31	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scytalidopepsin A"
EC:3.4.23.31	skos:altLabel	"Scytalidium aspartic proteinase A"
RHEA:12844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine + pyruvate <=> L-alanine + pyridoxal
REACT:R-SCE-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)
REACT:R-SCE-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Saccharomyces cerevisiae)
RHEA:30547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O
RHEA:11835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) <=> H(+) + NADH + naphthalene-1,2-diol
REACT:R-BTA-9029551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Bos taurus)
REACT:R-DDI-6814682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of early-endosome derived vesicles at the TGN (Dictyostelium discoideum)
REACT:R-XTR-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Xenopus tropicalis)
RHEA:49928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-1678660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan sulfate chain(3) (Danio rerio)
RHEA:47583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GT2 (d18:1(4E)) + H(+) + UDP
RHEA:68194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + decanoate phytyl ester => decanoyl-CoA + phytol
REACT:R-GGA-353268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Pol zeta complex to a DNA template containing lesions (Gallus gallus)
RHEA:42834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-acetyloctanal + CO2 => (2E)-octenal + H(+) + pyruvate
RHEA:44432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acylglycerol = a 1,2-diacylglycerol + glycerol
REACT:R-SPO-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)
REACT:R-DME-1889981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Drosophila melanogaster)
REACT:R-DRE-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Danio rerio)
REACT:R-HSA-8950752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12A:IL12B translocates from Golgi lumen to late endosome lumen (Homo sapiens)
RHEA:58991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H2O + O2 <=> (E)-4-hydroxynon-2-enoate + H(+) + H2O2
REACT:R-BTA-2076508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS2ST1 sulfates IdoA at C2 in heparan sulfate (Bos taurus)
REACT:R-SSC-114552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate G12/13 (Sus scrofa)
REACT:R-MMU-422454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polysialylation of NCAM1 (Mus musculus)
RHEA:31464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crocetin + UDP-alpha-D-glucose => beta-D-glucosyl crocetin + UDP
REACT:R-CFA-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Canis familiaris)
REACT:R-BTA-373061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR3, 4 and 5 bind CCL5 ligand (Bos taurus)
REACT:R-DRE-8875816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds activated MET receptor (Danio rerio)
REACT:R-SPO-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Schizosaccharomyces pombe)
REACT:R-DME-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Drosophila melanogaster)
RHEA:44861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 4,8-dimethylnonanoyl-CoA => CoA + O-4,8-dimethylnonanoyl-(R)-carnitine
RHEA:58372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + H(+) + NADPH
RHEA:59239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + isoelisabethatriene
REACT:R-BTA-5218645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 binds p-Y397-PTK2 (Bos taurus)
RHEA:62667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'R)-atrovenetin + S-adenosyl-L-methionine <=> deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine
RHEA:11898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholest-4-en-3-one + H(+) + NADH => 7alpha-hydroxycholesterol + NAD(+)
REACT:R-GGA-372903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate + NAD+ <=> pyruvate + NADH + H+ (Gallus gallus)
REACT:R-GGA-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)
GO:1901531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypochlorite binding
REACT:R-GGA-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Gallus gallus)
REACT:R-SSC-6800299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGFAC cleaves pro-HGF to form HGF dimer (Sus scrofa)
REACT:R-RNO-5693742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH hydrolyses AEA to AA and ETA (Rattus norvegicus)
REACT:R-CFA-6795667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the cytosol (Canis familiaris)
RHEA:71688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-aspartate(out) + 2 H(+)(out) => glycyl-L-aspartate(in) + 2 H(+)(in)
REACT:R-RNO-6799191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Rattus norvegicus)
REACT:R-DME-200143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)
RHEA:30039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 = benzene-1,2,4-triol + CO2 + H2O + NADP(+)
RHEA:34562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11beta-hydroxypentalenate + NAD(+) <=> 1-deoxy-11-oxopentalenate + H(+) + NADH
RHEA:71017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylaminobutanal + H2O2 + NH4(+) => H2O + N-methylputrescine + O2
EC:1.4.3.5	skos:altLabel	"PMP oxidase"
EC:1.4.3.5	skos:altLabel	"pyridoxamine 5'-phosphate oxidase"
EC:1.4.3.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxal 5'-phosphate synthase"
EC:1.4.3.5	skos:altLabel	"pyridoxine (pyridoxamine) 5'-phosphate oxidase"
EC:1.4.3.5	skos:altLabel	"pyridoxine (pyridoxamine)phosphate oxidase"
EC:1.4.3.5	skos:prefLabel	"pyridoxal 5'-phosphate synthase"
EC:1.4.3.5	skos:altLabel	"pyridoxamine phosphate oxidase"
EC:1.4.3.5	skos:altLabel	"pyridoxamine-phosphate oxidase"
REACT:R-PFA-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Plasmodium falciparum)
REACT:R-XTR-209921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoiodinated tyrosine can be deiodinated (Xenopus tropicalis)
REACT:R-SSC-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Sus scrofa)
RHEA:69826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:29175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 O2 + ubiquinol-8 = 2 H(+) + 2 superoxide + ubiquinone-8
RHEA:63192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + 2 H(+) + phosphate
RHEA:63192	skos:prefLabel	"[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming)"
RHEA:63192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming)"
REACT:R-XTR-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Xenopus tropicalis)
REACT:R-MMU-1861621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIA with IgG-coated Ag (Mus musculus)
RHEA:51016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-phosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate
RHEA:51016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroneopterin phosphate aldolase"
RHEA:51016	skos:prefLabel	"dihydroneopterin phosphate aldolase"
RHEA:51016	skos:altLabel	"H2NMP aldolase"
RHEA:17297	skos:altLabel	"KGOR"
RHEA:17297	skos:altLabel	"2-ketoglutarate ferredoxin oxidoreductase"
RHEA:17297	skos:prefLabel	"2-oxoglutarate synthase"
RHEA:17297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA
RHEA:17297	skos:altLabel	"alpha-ketoglutarate synthase"
RHEA:17297	skos:altLabel	"2-oxoglutarate ferredoxin oxidoreductase"
RHEA:17297	skos:altLabel	"alpha-ketoglutarate-ferredoxin oxidoreductase"
RHEA:17297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoglutarate synthase"
REACT:R-CFA-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Canis familiaris)
GO:0050186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylylsulfate sulfohydrolase activity
GO:0050186	skos:prefLabel	"phosphoadenylylsulfatase"
GO:0050186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoadenylyl sulfatase activity
GO:0050186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoadenosine 5-phosphosulfate sulfatase activity
GO:0050186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + sulfate
GO:0050186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS sulfatase activity
GO:0050186	skos:altLabel	"3-phosphoadenylyl sulfatase"
GO:0050186	skos:altLabel	"PAPS sulfatase"
GO:0050186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoadenylylsulfatase"
GO:0050186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoadenylylsulphatase activity
GO:0050186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoadenylylsulfatase activity
REACT:R-CFA-5607751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes (Canis familiaris)
REACT:R-MMU-3222020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUAK1 phosphorylates TP53 (Mus musculus)
GO:0047139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-homocystine transhydrogenase activity
GO:0047139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:homocystine oxidoreductase activity
REACT:R-XTR-200396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Creatine transport across the plasma membrane (Xenopus tropicalis)
REACT:R-SSC-9709317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to free ferrohemoglobin (Sus scrofa)
RHEA:58103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(15Z-tetracosenoyl)-glycerol + H2O <=> (15Z)-tetracosenoate + glycerol + H(+)
REACT:R-XTR-2028583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS2 (Xenopus tropicalis)
RHEA:35445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose
RHEA:35630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP
GO:0047389	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphohydrolase activity
GO:0047389	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycero-3-phosphocholine glycerophosphohydrolase activity
GO:0047389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDPD5 hydrolyzes GPCho (Homo sapiens)
GO:0047389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophosphocholine phosphodiesterase activity
GO:0047389	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycero-3-phosphorylcholine diesterase activity
GO:0047389	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerylphosphorylcholinediesterase activity
GO:0047389	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphinicocholine diesterase activity
GO:0047389	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerolphosphorylcholine phosphodiesterase activity
REACT:R-SPO-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Schizosaccharomyces pombe)
RHEA:32723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5228406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetX HC transports tetX LC from target cell endosome membrane into cytosol (Homo sapiens)
REACT:R-CEL-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Caenorhabditis elegans)
RHEA:52731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate <=> a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-9684277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA1 is translated to pp1ab (Homo sapiens)
REACT:R-CFA-418176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB2 binds MAPKs, SRC-1 (Canis familiaris)
RHEA:15717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daunorubicin + H(+) + NADPH + O2 = doxorubicin + H2O + NADP(+)
RHEA:27756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + H(+) => H2O + methylglyoxal
RHEA:15811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O
RHEA:68107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone
RHEA:45852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(II)-factor III + H(+) + S-adenosyl-L-methionine = Co(II)-factor IV + S-adenosyl-L-homocysteine
RHEA:57772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite
RHEA:12991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + D-mannose + H(+) => a dolichyl beta-D-mannosyl phosphate + H2O
REACT:R-GGA-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Gallus gallus)
REACT:R-RNO-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Rattus norvegicus)
REACT:R-MMU-6799495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYCTK phosphorylates DGA to 3PDGA (Mus musculus)
RHEA:39844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA
REACT:R-CEL-5624494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 binds p21 RAS:GTP (Caenorhabditis elegans)
RHEA:57980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside F1 + H(+) + UDP
RHEA:49614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + NADH => (R)-2-hydroxyglutarate + NAD(+)
REACT:R-HSA-429992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARN deadenylates mRNA (Homo sapiens)
GO:0005302	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-tyrosine transporter activity
GO:0005302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine permease activity
GO:0005302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine/tyrosine/tryptophan permease activity
GO:0005302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine transmembrane transporter activity
REACT:R-HSA-9673173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBEA binds GLRB (Homo sapiens)
REACT:R-CFA-205117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR:NADE promotes caspase2/3 activation (Canis familiaris)
REACT:R-MMU-174202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Securin (Mus musculus)
RHEA:64684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP
RHEA:27765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H2O <=> CMP + diphosphate + H(+)
REACT:R-SSC-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Sus scrofa)
GO:0031851	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	kappa-type opioid receptor ligand
GO:0031851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kappa-type opioid receptor binding
GO:0031851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dynorphin receptor binding
REACT:R-SSC-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Sus scrofa)
REACT:R-MMU-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Mus musculus)
RHEA:72345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol => 3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)
RHEA:51349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine => 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine
REACT:R-DME-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Drosophila melanogaster)
RHEA:61310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-PFA-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Plasmodium falciparum)
REACT:R-GGA-2404137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)
REACT:R-DME-996727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST recruits the BHC complex (Drosophila melanogaster)
REACT:R-RNO-2066779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Rattus norvegicus)
REACT:R-CFA-5607742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)
GO:0035595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminylinositol deacetylase activity
GO:0035595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-1D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase activity
GO:0035595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc-Ins deacetylase activity
GO:0035595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase activity
GO:0035595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase activity
REACT:R-BTA-191656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Closure of gap junction (Bos taurus)
RHEA:63113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ascofuranol => AH2 + ascofuranone
REACT:R-BTA-5668543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3:NIK binds TRAF2:cIAP1/2 (Bos taurus)
GO:0051992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
GO:0055104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase inhibitor activity
REACT:R-DRE-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Danio rerio)
REACT:R-DDI-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Dictyostelium discoideum)
RHEA:56350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+) => 4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2
GO:0051015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin filament binding
GO:0051015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin binding
GO:0051015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	actin cross-linking activity
REACT:R-GGA-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Gallus gallus)
REACT:R-RNO-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Rattus norvegicus)
REACT:R-RNO-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Rattus norvegicus)
RHEA:10883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthosine + H2O <=> 7-methylxanthine + D-ribose + H(+)
REACT:R-MMU-158333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Mus musculus)
REACT:R-DRE-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Danio rerio)
RHEA:49850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (-)-dehydrodiconiferyl acid ketone + a quinone + H2O
RHEA:11302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH => 1D-5-O-methyl-myo-inositol + NAD(+)
RHEA:67119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:24186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + CO2 => 4,5-dihydroxyphthalate + H(+)
GO:0050608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vanillin:NAD+ oxidoreductase activity
GO:0050608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vanillin dehydrogenase activity
GO:0050608	skos:prefLabel	"vanillin dehydrogenase"
GO:0050608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate
GO:0050608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vanillin dehydrogenase"
REACT:R-CFA-9700121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN,MDK):PTPRZ oligomerizes (Canis familiaris)
REACT:R-DRE-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Danio rerio)
REACT:R-HSA-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Homo sapiens)
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA-directed DNA polymerase, group II intron encoded
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA-dependent deoxyribonucleate nucleotidyltransferase activity
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA-directed DNA polymerase, transposon encoded
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA-instructed DNA polymerase activity
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA revertase activity
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RT
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA nucleotidyltransferase (RNA-directed) activity
GO:0003964	skos:prefLabel	"RNA-directed DNA polymerase"
GO:0003964	skos:altLabel	"reverse transcriptase"
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RNA-directed DNA polymerase"
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA-dependent DNA polymerase activity
GO:0003964	skos:altLabel	"revertase"
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reverse transcriptase activity
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	revertase activity
GO:0003964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-directed DNA polymerase activity
GO:0003964	skos:altLabel	"DNA nucleotidyltransferase (RNA-directed)"
RHEA:28549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose <=> alpha-D-fructose
RHEA:17545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] = [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]
RHEA:17545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfiredoxin"
RHEA:17545	skos:altLabel	"peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase"
RHEA:17545	skos:prefLabel	"sulfiredoxin"
REACT:R-HSA-2213236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Homo sapiens)
RHEA:18075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + orotate => (S)-dihydroorotate + A
RHEA:65189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + berkeleyone B + O2 => berkeleydione + CO2 + H2O + succinate
RHEA:22597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cephalosporin C + H2O => acetate + deacetylcephalosporin C + H(+)
REACT:R-DRE-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Danio rerio)
REACT:R-SSC-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Sus scrofa)
REACT:R-DRE-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Danio rerio)
REACT:R-DME-192341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Drosophila melanogaster)
RHEA:17504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + polyneuridine aldehyde <=> 16-epivellosimine + CO2 + methanol
REACT:R-HSA-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Homo sapiens)
RHEA:30783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + H2O + NAD(+) = (R)-glycerate + 2 H(+) + NADH
REACT:R-BTA-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Bos taurus)
RHEA:55831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)
REACT:R-XTR-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Xenopus tropicalis)
REACT:R-HSA-9686174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Accessory proteins are recruited to the maturing virion (Homo sapiens)
REACT:R-MMU-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Mus musculus)
RHEA:21553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
RHEA:22421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) => 2 H(+) + maleylacetate + NADH
RHEA:40438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine
REACT:R-CFA-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)
REACT:R-BTA-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Bos taurus)
REACT:R-GGA-9686088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDMD (Gallus gallus)
RHEA:29692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltotetraose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotriose
REACT:R-GGA-8987220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Gallus gallus)
RHEA:59340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A = 1'-hydroxy-demethylspheroidene + AH2
REACT:R-SCE-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
REACT:R-HSA-2426158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C binds the GPAM promoter (Homo sapiens)
REACT:R-PFA-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)
REACT:R-XTR-265010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Xenopus tropicalis)
RHEA:69776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => beta-ylangene + diphosphate
REACT:R-RNO-1461971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Rattus norvegicus)
RHEA:15713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactoside + acetyl-CoA = a 6-acetyl-beta-D-galactoside + CoA
RHEA:15713	skos:prefLabel	"galactoside O-acetyltransferase"
RHEA:15713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactoside O-acetyltransferase"
RHEA:15713	skos:altLabel	"thiogalactoside acetyltransferase"
GO:0033952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iota-carrageenase activity
GO:0033952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity
RHEA:66049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate
GO:0102257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity
REACT:R-HSA-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
REACT:R-RNO-5662606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds zinc (Rattus norvegicus)
RHEA:60906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2
RHEA:56879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N-acetyl-1-phenylethylamine + H2O <=> (R)-1-phenylethylamine + acetate
REACT:R-GGA-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Gallus gallus)
RHEA:45746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydropteroate + H(+) + NADH => (6S)-5,6,7,8-tetrahydropteroate + NAD(+)
RHEA:32740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
RHEA:35250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate
REACT:R-HSA-9758529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 N binds MASP2 (Homo sapiens)
REACT:R-BTA-2395873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)
REACT:R-RNO-72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of mRNA at the 3'-end (Rattus norvegicus)
REACT:R-SSC-8852809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPN, CPB2 cleave C3a, C5a (Sus scrofa)
REACT:R-GGA-2187405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 binds phosphorylated SMAD2/3 (Gallus gallus)
REACT:R-DRE-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Danio rerio)
REACT:R-HSA-389826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NADPH + H+ => glycolate + NADP+ (Homo sapiens)
RHEA:23351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2
REACT:R-SSC-9714691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds ER effectors (Sus scrofa)
RHEA:64411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out) <=> H(+)(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in)
RHEA:44560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-heptaprenyl diphosphate = 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate
REACT:R-RNO-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Rattus norvegicus)
RHEA:17386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypotaurine + NAD(+) => H(+) + NADH + taurine
RHEA:54687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-kolavenyl diphosphate
RHEA:64201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-leucine + H2O => a fatty acid + L-leucine
REACT:R-XTR-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Xenopus tropicalis)
REACT:R-DME-5422942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXRA:PPARD binds FABP5:atRA (Drosophila melanogaster)
REACT:R-SSC-6785342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Sus scrofa)
RHEA:21447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-hydroxyphenyl)propanoate + NAD(+) <=> H(+) + NADH + trans-2-coumarate
REACT:R-CEL-9638076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from small HA fragments (Caenorhabditis elegans)
RHEA:62640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycoredoxin-dependent peroxiredoxin"
RHEA:62640	skos:prefLabel	"mycoredoxin-dependent peroxiredoxin"
RHEA:62640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycoredoxin]-L-dithiol + a hydroperoxide = [mycoredoxin]-L-disulfide + an alcohol + H2O
RHEA:40115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanoyl-CoA = CoA + H(+) + hexanoate
REACT:R-SCE-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Saccharomyces cerevisiae)
GO:0031847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 neurotensin receptor binding
GO:0031847	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 neurotensin receptor ligand
REACT:R-BTA-2569057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP3 binds TRIF to mediate necroptosis (Bos taurus)
REACT:R-XTR-202721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 binds JAM3 (Xenopus tropicalis)
RHEA:12095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-acetoin <=> (R)-acetoin
RHEA:47769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:43310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-sn-glycerol + ATP
REACT:R-MMU-9762345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDN:ALB dissociates (Mus musculus)
REACT:R-HSA-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)
REACT:R-RNO-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Rattus norvegicus)
GO:0016631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-[acyl-carrier-protein] reductase activity
GO:0016631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-acyl carrier protein reductase
GO:0016631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-ACP dehydrogenase activity
GO:0016631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-[acyl-carrier protein] reductase activity
GO:0016631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-ACP reductase activity
RHEA:69897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(in) + Na(+)(in) => cytidine(out) + Na(+)(out)
RHEA:65626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine => hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine
RHEA:27280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+)
RHEA:23406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate
RHEA:65169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + preaustinoid A => A + H2O + preaustinoid A1
GO:0016596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thienylcyclohexylpiperidine binding
GO:0016596	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	TCP binding
REACT:R-CFA-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Canis familiaris)
RHEA:67211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + melatonin <=> 5-methoxytryptamine + acetate
REACT:R-CEL-9707353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 binds Aromatase inhibitors (Caenorhabditis elegans)
RHEA:51659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagaturonate <=> keto-D-fructuronate
RHEA:56426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-8937654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 positively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)
REACT:R-SSC-166726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MASPs (Sus scrofa)
REACT:R-HSA-8950731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:IL27 translocates to the extracellular region (Homo sapiens)
REACT:R-CFA-1855219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)
REACT:R-DME-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
RHEA:55896	skos:prefLabel	"tryptophan 5-halogenase"
RHEA:55896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + L-tryptophan + O2 = 5-chloro-L-tryptophan + FAD + 2 H2O
RHEA:55896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan 5-halogenase"
REACT:R-SPO-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Schizosaccharomyces pombe)
RHEA:31045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + methylmalonate + NADH => (S)-methylmalonate semialdehyde + H2O + NAD(+)
REACT:R-MMU-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Mus musculus)
REACT:R-RNO-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Rattus norvegicus)
RHEA:14429	skos:altLabel	"oligopeptide permease"
RHEA:14429	skos:altLabel	"oligopeptide-transporting ATPase"
RHEA:14429	skos:prefLabel	"ABC-type oligopeptide transporter"
RHEA:14429	skos:altLabel	"oligopeptide ABC transporter"
RHEA:14429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [oligopeptide](in) + ATP + H2O = a [oligopeptide](out) + ADP + H(+) + phosphate
RHEA:14429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type oligopeptide transporter"
RHEA:49430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-5'-phosphonoformate + diphosphate => CTP + phosphonoformate
REACT:R-HSA-211712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic PAK-2p34 fragment translocates to the nucleus (Homo sapiens)
REACT:R-CFA-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Canis familiaris)
REACT:R-CFA-5229283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCNs bind lipids (Canis familiaris)
GO:0015155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose transmembrane transporter activity
GO:0015155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose permease activity
GO:0015155	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lactose/glucose efflux transporter activity
REACT:R-PFA-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)
REACT:R-SPO-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Schizosaccharomyces pombe)
REACT:R-SSC-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Sus scrofa)
RHEA:42966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(54/55) in tRNA => uridine(54/55) in tRNA
REACT:R-DDI-2161907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Dictyostelium discoideum)
RHEA:27385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + maleamate = maleate + NH4(+)
RHEA:27385	skos:prefLabel	"maleamate amidohydrolase"
RHEA:27385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maleamate amidohydrolase"
RHEA:50687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-phenyl-L-glutamine <=> aniline + H(+) + L-glutamate
RHEA:24026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine => (2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate
REACT:R-HSA-9712082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK fusions phosphorylate IRS1 (Homo sapiens)
REACT:R-MMU-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Mus musculus)
REACT:R-HSA-191737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of connexons into junctional, double-membrane spanning channels (Homo sapiens)
REACT:R-BTA-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Bos taurus)
REACT:R-HSA-9761818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds the GSR gene (Homo sapiens)
RHEA:56353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)
RHEA:32461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + uroporphyrinogen III
RHEA:20492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)
RHEA:42594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA
RHEA:64333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + nicotinate => AMP + diphosphate + nicotinyl-CoA
RHEA:46302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone
GO:0033161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitogen-activated protein kinase kinase kinase kinase binding
GO:0033161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKKKK binding
REACT:R-XTR-5218830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates PTK2-beta (Xenopus tropicalis)
REACT:R-BTA-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Bos taurus)
REACT:R-CEL-77587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Replication Dependent Histone mRNA with the NPC (Caenorhabditis elegans)
RHEA:24313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[cytochrome c] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine
REACT:R-GGA-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Gallus gallus)
REACT:R-SSC-391151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47:SKAP2 binds FYB (Sus scrofa)
REACT:R-BTA-5674496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate MAP2K1 (Bos taurus)
RHEA:61942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose
RHEA:34942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + menaquinone-8 + selenite <=> menaquinol-8 + selenate
REACT:R-SSC-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Sus scrofa)
GO:0106073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity
RHEA:48695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
RHEA:53472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate
GO:0120225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA binding
GO:0120225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme A binding
RHEA:47052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = alpha-selinene + diphosphate
RHEA:64022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + O-phospho-L-seryl-[protein] => GTP + L-seryl-[protein]
REACT:R-DDI-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Dictyostelium discoideum)
REACT:R-CFA-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Canis familiaris)
REACT:R-HSA-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Homo sapiens)
RHEA:56221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP
RHEA:23200	skos:prefLabel	"N(6)-methyl-lysine oxidase"
RHEA:23200	skos:altLabel	"epsilon-N-methyllysine demethylase"
RHEA:23200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(6)-methyl-lysine oxidase"
RHEA:23200	skos:altLabel	"epsilon-alkyllysinase"
RHEA:23200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-methyl-L-lysine + O2 = formaldehyde + H2O2 + L-lysine
RHEA:23200	skos:altLabel	"N(6)-methyllysine oxidase"
RHEA:15851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate => 2 Fe(III)-[cytochrome c] + L-ascorbate
REACT:R-BTA-350869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Bos taurus)
REACT:R-DME-111285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)
RHEA:62598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeranial + H(+) + NADH => (S)-8-oxocitronellyl enol + NAD(+)
RHEA:41414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-MMU-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)
EC:3.4.24.31	skos:altLabel	"Streptomyces griseus neutral proteinase"
EC:3.4.24.31	skos:prefLabel	"mycolysin"
EC:3.4.24.31	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycolysin"
EC:3.4.24.31	skos:altLabel	"pronase component"
RHEA:29422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Na(+)(in) <=> H(+)(in) + Na(+)(out)
RHEA:63654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-SCE-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Saccharomyces cerevisiae)
REACT:R-HSA-170153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Homo sapiens)
RHEA:14790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP
GO:0004727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenylated protein tyrosine phosphatase activity
GO:0062213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxynitrite = nitrate
GO:0062213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxynitrite isomerase activity
REACT:R-DRE-5653886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1 binds LALBA (Danio rerio)
RHEA:15969	skos:prefLabel	"methylarsonate reductase"
RHEA:15969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylarsonate reductase"
RHEA:15969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid
RHEA:15969	skos:altLabel	"MMA(V) reductase"
REACT:R-CFA-5684836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC1B dimer binds PDPN (Canis familiaris)
REACT:R-DME-8849348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Drosophila melanogaster)
RHEA:31979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trimethylamine monooxygenase"
RHEA:31979	skos:prefLabel	"trimethylamine monooxygenase"
RHEA:31979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + trimethylamine = H2O + NADP(+) + trimethylamine N-oxide
RHEA:31979	skos:altLabel	"flavin-containing monooxygenase 3"
GO:0018708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiol methyltransferase activity
GO:0018708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TMT
GO:0018708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiol S-methyltransferase activity
GO:0018708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:thiol S-methyltransferase activity
REACT:R-RNO-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)
REACT:R-HSA-1112565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
RHEA:42392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + NAD(+) = D-galactono-1,5-lactone + H(+) + NADH
REACT:R-RNO-5615637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Rattus norvegicus)
REACT:R-CFA-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Canis familiaris)
REACT:R-SSC-193700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR ICD signals to NF-kB (Sus scrofa)
RHEA:50226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine
RHEA:43432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-butanol dehydrogenase (cytochrome c)"
RHEA:43432	skos:prefLabel	"1-butanol dehydrogenase (cytochrome c)"
RHEA:43432	skos:altLabel	"BDH"
RHEA:43432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + 2 Fe(III)-[cytochrome c] = butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-SSC-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Sus scrofa)
GO:0047977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hepoxilin epoxide hydrolase activity
GO:0047977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity
GO:0047977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hepoxilin A(3) hydrolase activity
GO:0047977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hepoxilin-epoxide hydrolase activity
GO:0047977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hepoxylin hydrolase activity
GO:0047977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hepoxilin A3 hydrolase activity
RHEA:13119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(pyrazol-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + pyrazole
REACT:R-DME-432464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated TIM:PER heterodimer dissociate (Drosophila melanogaster)
RHEA:69362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-L-tyrosyl-[protein] + 2 H2O => bromide + H(+) + H2O2 + L-tyrosyl-[protein]
RHEA:65616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cholest-4-en-3-one + H2O = 25-hydroxycholest-4-en-3-one + AH2
RHEA:29890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-lysine(out) <=> ADP + H(+) + L-lysine(in) + phosphate
REACT:R-MMU-8855915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Mus musculus)
RHEA:64222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine
GO:0010307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylglutamate kinase regulator activity
REACT:R-BTA-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Bos taurus)
REACT:R-MMU-202726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F11R dimerises (Mus musculus)
RHEA:56491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]
RHEA:51177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Dictyostelium discoideum)
REACT:R-BTA-1793182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Bos taurus)
REACT:R-DRE-8964317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Danio rerio)
RHEA:47981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose
RHEA:31378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pyrrole-2-carboxylate <=> 1H-pyrrole + CO2
REACT:R-HSA-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
REACT:R-DRE-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Danio rerio)
RHEA:54649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O
REACT:R-MMU-109470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Mus musculus)
RHEA:22529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP
REACT:R-MMU-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Mus musculus)
RHEA:69112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-2-aminoadipate = 2-oxoadipate + glycine
GO:0015313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluconazole:proton antiporter activity
GO:0015313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluconazole:hydrogen antiporter activity
REACT:R-CFA-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Canis familiaris)
REACT:R-BTA-5577050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Bos taurus)
RHEA:30499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-valine = (E)-2-methylpropanal oxime + CO2 + H2O
RHEA:31652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine
REACT:R-CFA-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Canis familiaris)
RHEA:31221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-L-kynurenine + H(+) => 5-hydroxykynurenamine + CO2
REACT:R-DDI-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Dictyostelium discoideum)
RHEA:62363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-N(5)-peroxide + uracil <=> (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)
RHEA:27670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate
RHEA:17537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnitinamidase"
RHEA:17537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinamide + H2O = (R)-carnitine + NH4(+)
RHEA:17537	skos:prefLabel	"carnitinamidase"
RHEA:39986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:49840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid + 2 a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)
RHEA:32472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] => (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)
EC:3.4.13.12	skos:altLabel	"dipeptidase M"
EC:3.4.13.12	skos:prefLabel	"Met-Xaa dipeptidase"
EC:3.4.13.12	skos:altLabel	"methionyl dipeptidase"
EC:3.4.13.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Met-Xaa dipeptidase"
EC:3.4.13.12	skos:altLabel	"Met-X dipeptidase"
REACT:R-SSC-9686922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 binds activated RIPK1:RIPK3 (Sus scrofa)
RHEA:67915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid
RHEA:10259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate
REACT:R-DME-2168886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemopexin binds Hemes (Drosophila melanogaster)
REACT:R-DRE-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Danio rerio)
GO:0018681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deisopropylatrazine monooxygenase activity
REACT:R-CFA-1889981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Canis familiaris)
REACT:R-MMU-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Mus musculus)
RHEA:28662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-lactose + H2O <=> beta-D-galactose + beta-D-glucose
REACT:R-SSC-1250220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of ERBB4 (Sus scrofa)
RHEA:18864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Homo sapiens)
REACT:R-DRE-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Danio rerio)
REACT:R-BTA-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Bos taurus)
REACT:R-SSC-981809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Sus scrofa)
REACT:R-BTA-1251997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ERBB4m80 by gamma-scretase complex (Bos taurus)
REACT:R-GGA-3341343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)
RHEA:64405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine(out) + H(+)(out) => carnosine(in) + H(+)(in)
REACT:R-SCE-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Saccharomyces cerevisiae)
REACT:R-DRE-114307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SMAC (DIABLO) from mitochondria (Danio rerio)
RHEA:11314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + H(+) + hydroxyatrazine => atrazine + H2O
RHEA:54960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + dinor-OPDA = AMP + dinor-OPDA-CoA + diphosphate
REACT:R-BTA-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Bos taurus)
REACT:R-RNO-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Rattus norvegicus)
RHEA:22950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => D-tagatofuranose 1,6-bisphosphate
RHEA:11588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + isoquinoline = AH2 + isoquinolin-1(2H)-one
RHEA:11588	skos:prefLabel	"isoquinoline 1-oxidoreductase"
RHEA:11588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoquinoline 1-oxidoreductase"
REACT:R-SSC-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Sus scrofa)
RHEA:15076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O <=> D-glucuronate + N(2),6-disulfo-D-glucosamine
RHEA:26219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-9663511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds GSTA1, FABP1 (Canis familiaris)
REACT:R-DRE-9749494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBIP binds IKBKB and CHUK (Danio rerio)
RHEA:57108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-201639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of GAS2 (Xenopus tropicalis)
REACT:R-DME-3791149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Drosophila melanogaster)
RHEA:49413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose => alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)
REACT:R-SSC-5696670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD1L is recruited to GG-NER site (Sus scrofa)
REACT:R-MMU-71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Mus musculus)
RHEA:41587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-tyrosine <=> 4-O-dimethylallyl-L-tyrosine + diphosphate
REACT:R-BTA-4722133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Bos taurus)
REACT:R-MMU-388863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Mus musculus)
REACT:R-CFA-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Canis familiaris)
REACT:R-DDI-110355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MUTYH glycosylase by APEX1 at the AP site (Dictyostelium discoideum)
RHEA:72315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(in) + leukotriene C4(out) = glutathione(out) + leukotriene C4(in)
RHEA:50903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O <=> (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate
GO:0018466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene-1,2-diol dehydrogenase activity
REACT:R-CFA-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)
RHEA:47186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-MMU-8849102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRMS phosphorylates PTK6 (Mus musculus)
RHEA:56376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)
GO:0047445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)
GO:0047445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyisohexenylglutaryl-CoA:acetatelyase activity
GO:0047445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity
GO:0047445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-isohexenylglutaryl-CoA lyase activity
GO:0047445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity
GO:0047445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity
GO:0047445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity
REACT:R-SCE-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Saccharomyces cerevisiae)
REACT:R-DRE-2395965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)
REACT:R-MMU-216757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Mus musculus)
REACT:R-HSA-5618098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Homo sapiens)
RHEA:35701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S-3S)-versiconal hemiacetal + H(+) + NADPH => (S)-versiconol + NADP(+)
REACT:R-HSA-9684273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3CLp cleaves pp1a (Homo sapiens)
RHEA:47754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => 5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine
REACT:R-XTR-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)
RHEA:55086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxypentanoate + CoA + H(+) => (3R)-3-hydroxypentanoyl-CoA + H2O
REACT:R-MMU-8982617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB:O2 dissociates (Mus musculus)
RHEA:61749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rubusoside + UDP-alpha-D-glucose => H(+) + stevioside + UDP
REACT:R-CEL-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Caenorhabditis elegans)
GO:0048763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-induced calcium release activity
REACT:R-HSA-9605259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds FYN (Homo sapiens)
RHEA:22239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose 6-phosphate + H2O <=> 2-deoxy-D-glucose + phosphate
RHEA:38071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA
RHEA:21478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose
REACT:R-MMU-6784735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR bind to Clathrin (Mus musculus)
RHEA:23267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH
RHEA:13564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)
RHEA:61237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionine + O2 => 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)
RHEA:27965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + pyrroloquinoline quinone <=> H(+) + pyrroloquinoline quinol + scyllo-inosose
EC:2.7.11.21	skos:prefLabel	"polo kinase"
EC:2.7.11.21	skos:altLabel	"polo-like kinase"
EC:2.7.11.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polo kinase"
EC:2.7.11.21	skos:altLabel	"polo serine-threonine kinase"
EC:2.7.11.21	skos:altLabel	"PLK"
REACT:R-DME-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)
REACT:R-DRE-5696838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Danio rerio)
EC:3.8.1.11	skos:altLabel	"DL-DEXr"
EC:3.8.1.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-haloacid dehalogenase (configuration-retaining)"
EC:3.8.1.11	skos:altLabel	"2-haloalkanoic acid dehalogenase"
EC:3.8.1.11	skos:altLabel	"2-haloalkanoid acid halidohydrolase"
EC:3.8.1.11	skos:altLabel	"DL-2-haloacid dehalogenase"
EC:3.8.1.11	skos:prefLabel	"2-haloacid dehalogenase (configuration-retaining)"
RHEA:64413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)
RHEA:63329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + ATP => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:31493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + soyasaponin I + UDP => soyasaponin III + UDP-beta-L-rhamnose
REACT:R-DME-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Drosophila melanogaster)
REACT:R-SSC-163099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alignment Of The RNA Template On The Telomeric Chromosome End (Sus scrofa)
RHEA:38350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate
RHEA:21944	skos:prefLabel	"beta-glucoside kinase"
RHEA:21944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-glucoside kinase"
RHEA:21944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-cellobiose = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)
RHEA:28767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylnitronate + O2 = acetaldehyde + chemical entity + H(+) + nitrite
RHEA:28767	skos:prefLabel	"nitronate monooxygenase"
RHEA:28767	skos:altLabel	"NMO"
RHEA:28767	skos:altLabel	"2-nitropropane dioxygenase"
RHEA:28767	skos:altLabel	"2-NPD"
RHEA:28767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitronate monooxygenase"
RHEA:28767	skos:altLabel	"nitroalkane oxidase"
REACT:R-BTA-5694077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Bos taurus)
REACT:R-PFA-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Plasmodium falciparum)
RHEA:23055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]
RHEA:36990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + phosphate <=> alpha-D-ribose 1,5-bisphosphate + cytosine
REACT:R-MMU-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Mus musculus)
GO:0050568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glutamine glutaminase activity
GO:0050568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminyl-peptide glutaminase activity
GO:0050568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidylglutaminase II
GO:0050568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminylpeptide glutaminase activity
GO:0050568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidoglutaminase II activity
GO:0050568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-L-glutamine amidohydrolase activity
GO:0050568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	destabilase activity
REACT:R-CFA-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Canis familiaris)
RHEA:50200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
RHEA:21625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NADP(+) => FMN + 2 H(+) + NADPH
REACT:R-SCE-6786652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIT1 hydrolyses CHIT to 3xADGP (Saccharomyces cerevisiae)
GO:0031473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin III binding
RHEA:42020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-dehydrocorticosterone + NAD(+) = H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone
REACT:R-HSA-9651280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)
RHEA:20376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + propanoate <=> AMP + diphosphate + propanoyl-CoA
REACT:R-DME-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Drosophila melanogaster)
REACT:R-HSA-139914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)
REACT:R-HSA-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Homo sapiens)
REACT:R-GGA-5689649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 (Gallus gallus)
REACT:R-CFA-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Canis familiaris)
REACT:R-HSA-204947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF migrates to the nucleus (Homo sapiens)
RHEA:71178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) <=> 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)
REACT:R-HSA-6803838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c-specific alternative splicing produces FGFR2c transcript (Homo sapiens)
EC:3.4.21.78	skos:altLabel	"cytotoxic T-lymphocyte proteinase 1"
EC:3.4.21.78	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"granzyme A"
EC:3.4.21.78	skos:prefLabel	"granzyme A"
GO:0102819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bixin aldehyde dehydrogenase activity
RHEA:50773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nitroethane + O2 => acetaldehyde + H(+) + H2O2 + nitrite
RHEA:17836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + S-adenosyl-L-methionine <=> 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine
RHEA:11742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + H(+) + NADPH => 2 glutathione + NADP(+)
REACT:R-DRE-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Danio rerio)
RHEA:46849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + CO2 + NADPH
GO:0036132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin 13-reductase activity
GO:0036132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin 13-reductase activity
GO:0036132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	15-oxo-delta13-prostaglandin reductase activity
GO:0036132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-prostaglandin reductase activity
GO:0036132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	15-ketoprostaglandin delta13-reductase activity
GO:0036132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin delta13-reductase activity
GO:0036132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta13-15-ketoprostaglandin reductase activity
REACT:R-SSC-159803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Sus scrofa)
REACT:R-GGA-8851877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Gallus gallus)
REACT:R-DRE-9008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds ESR1:estrogen:TGFA gene (Danio rerio)
RHEA:39116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH
RHEA:32898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mutildienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-DME-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)
RHEA:32252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH
REACT:R-MMU-158300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Mus musculus)
REACT:R-PFA-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Plasmodium falciparum)
RHEA:44409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)
REACT:R-XTR-73758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Xenopus tropicalis)
RHEA:32973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O
REACT:R-BTA-6805943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A1 binds TLR4:LY96 (Bos taurus)
RHEA:20080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(18) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SPO-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Schizosaccharomyces pombe)
RHEA:11044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a haloacetate + H2O = a halide anion + glycolate + H(+)
GO:0047059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyvinyl alcohol:ferricytochrome-c oxidoreductase activity
GO:0047059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyvinyl alcohol dehydrogenase (cytochrome) activity
GO:0047059	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyvinyl-alcohol:acceptor oxidoreductase activity
GO:0047059	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PVA dehydrogenase activity
GO:0047059	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyvinyl-alcohol:(acceptor) oxidoreductase activity
RHEA:43126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(10) in tRNA + 2 S-adenosyl-L-methionine
REACT:R-DDI-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)
REACT:R-XTR-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Xenopus tropicalis)
GO:0047281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioxotetrahydropyrimidine phosphoribosyltransferase activity
GO:0047281	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
GO:0047281	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity
GO:0047281	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity
GO:0047281	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity
GO:0047281	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dioxotetrahydropyrimidine phosphoribosyl transferase activity
GO:0004032	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldose reductase activity
GO:0004032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alditol:NADP+ 1-oxidoreductase activity
GO:0004032	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde reductase activity
GO:0004032	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyol dehydrogenase (NADP(+)) activity
RHEA:54579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 <=> an adenosine in tRNA + CO2 + formaldehyde + succinate
REACT:R-GGA-5690245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 binds DNAJB1 (Gallus gallus)
REACT:R-XTR-8944262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type X (Xenopus tropicalis)
REACT:R-DRE-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Danio rerio)
RHEA:68326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-phosphate + phosphate => 1D-myo-inositol 2,5-bisphosphate + H2O
RHEA:52098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-hydroxy-octadecanoate + H(+) + octadecanoate => 9-octadecanoyloxy-octadecanoate + H2O
RHEA:25538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ent-sandaracopimara-8(14),15-diene => ent-copalyl diphosphate
REACT:R-SSC-433101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Sus scrofa)
REACT:R-GGA-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Gallus gallus)
GO:0050335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isothiocyanate isomerase activity
GO:0050335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiocyanate isomerase activity
GO:0050335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzyl-thiocyanate isomerase activity
REACT:R-RNO-211882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A7 can 6beta-hydroxylate testosterone (Rattus norvegicus)
RHEA:40108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:14037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5beta-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH
REACT:R-CEL-2024084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS-GAGs translocate to the lysosome for degradation (Caenorhabditis elegans)
RHEA:14405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH
RHEA:65750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dodecanal + H(+) + succinate + sulfate => 2-oxoglutarate + dodecyl sulfate + O2
REACT:R-XTR-5676599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF trimer binds BAFFR (Xenopus tropicalis)
RHEA:11023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)
REACT:R-HSA-9648268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A antagonists (Homo sapiens)
REACT:R-SSC-199579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR2DL4 interacting with HLA-G (Sus scrofa)
REACT:R-MMU-9012657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Mus musculus)
REACT:R-CFA-1855169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)
REACT:R-GGA-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Gallus gallus)
REACT:R-CFA-9025152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Canis familiaris)
RHEA:68489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxytetradecanoate + H(+) => CO2 + H2O + tridecanal
RHEA:28819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate(in) + H(+)(in) = 5-dehydro-D-gluconate(out) + H(+)(out)
REACT:R-HSA-1655835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ELOVL6 (Homo sapiens)
REACT:R-RNO-2467798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTTG1 (Securin) sequesters ESPL1 (Separase) (Rattus norvegicus)
REACT:R-DME-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Drosophila melanogaster)
REACT:R-HSA-9634861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT2 (Homo sapiens)
RHEA:34585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + pentalenolactone E + succinate => 2-oxoglutarate + O2 + pentalenolactone D
RHEA:17870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydropteridine + NAD(+) => 6,7-dihydropteridine + H(+) + NADH
REACT:R-GGA-6783556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIFR:JAKs bind gp130:JAKs:CNTFR (Gallus gallus)
REACT:R-MMU-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Mus musculus)
RHEA:65005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + decanoate + holo-[ACP] => AMP + decanoyl-[ACP] + diphosphate
RHEA:51334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2
RHEA:13538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)
REACT:R-HSA-4793911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates HSF1 (Homo sapiens)
REACT:R-CEL-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Caenorhabditis elegans)
RHEA:12228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"asparagine synthase (glutamine-hydrolyzing)"
RHEA:12228	skos:altLabel	"asparagine synthetase (glutamine-hydrolyzing)"
RHEA:12228	skos:altLabel	"glutamine-dependent asparagine synthetase"
RHEA:12228	skos:prefLabel	"asparagine synthase (glutamine-hydrolyzing)"
RHEA:12228	skos:altLabel	"AS-B"
RHEA:12228	skos:altLabel	"asparagine synthetase B"
RHEA:12228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate
REACT:R-MMU-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Mus musculus)
RHEA:20486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5686301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 binds SFTPAs (Canis familiaris)
REACT:R-BTA-5625416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anterograde IFT (Bos taurus)
REACT:R-HSA-9625693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)
RHEA:20708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + erythritol = ADP + D-erythritol 4-phosphate + H(+)
RHEA:20708	skos:prefLabel	"erythritol kinase (D-erythritol 4-phosphate-forming)"
RHEA:20708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"erythritol kinase (D-erythritol 4-phosphate-forming)"
GO:0003864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity
GO:0003864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketopantoate hydroxymethyltransferase activity
GO:0003864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GO:0003864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoisovalerate hydroxymethyltransferase activity
GO:0003864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydropantoate hydroxymethyltransferase activity
GO:0003864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GO:0003864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxopantoate hydroxymethyltransferase activity
GO:0047426	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ricinine aminohydrolase activity
GO:0047426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ricinine nitrilase activity
REACT:R-XTR-5623513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 stimulates GTPase activity of ARF4 (Xenopus tropicalis)
RHEA:47964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate
REACT:R-DDI-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Dictyostelium discoideum)
GO:1990610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetolactate synthase regulator activity
REACT:R-HSA-2029984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2 ligand-independent  mutants (Homo sapiens)
REACT:R-HSA-9613498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the nascent HIV-1 transcript (Homo sapiens)
REACT:R-DRE-2473151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister centromeres (Danio rerio)
REACT:R-RNO-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Rattus norvegicus)
RHEA:43991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17beta,20alpha-hydroxysteroid dehydrogenase activity
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estradiol dehydrogenase activity
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17-beta-estradiol dehydrogenase activity
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17beta-hydroxysteroid dehydrogenase activity
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	17-beta-hydroxysteroid dehydrogenase activity
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estrogen 17-oxidoreductase activity
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	17-beta-HSD activity
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17beta-estradiol dehydrogenase activity
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17beta-HSD
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estradiol 17beta-dehydrogenase activity
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	20alpha-hydroxysteroid dehydrogenase
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estradiol-17beta:NAD(P)+ 17-oxidoreductase activity
GO:0004303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estradiol 17-beta-dehydrogenase activity
RHEA:56292	skos:altLabel	"CYP2C19"
RHEA:56292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56292	skos:prefLabel	"fenbendazole monooxygenase (4'-hydroxylating)"
RHEA:56292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fenbendazole monooxygenase (4'-hydroxylating)"
RHEA:54794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate => [nsP1 protein]-L-histidine + N(7)-methyl-GTP
RHEA:51968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate
REACT:R-CFA-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
REACT:R-HSA-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Homo sapiens)
REACT:R-DRE-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Danio rerio)
RHEA:48313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + H(+) + NADPH + O2 => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)
RHEA:70206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyldopaminechrome <=> 5,6-dihydroxyindole-N-methyl
RHEA:20928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-dithiol + a quinone = [DsbA protein]-disulfide + a quinol
RHEA:20928	skos:prefLabel	"protein dithiol:quinone oxidoreductase DsbB"
RHEA:20928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein dithiol:quinone oxidoreductase DsbB"
RHEA:49921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)
REACT:R-CFA-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)
RHEA:16479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin E1 + H(+) + NADH => NAD(+) + prostaglandin E1
REACT:R-SSC-5689000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Sus scrofa)
GO:0102209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-permethrin hydrolase activity
REACT:R-GGA-5578965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A binds AGO2:miRNA (Gallus gallus)
REACT:R-BTA-190682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin synthesis (generic) (Bos taurus)
REACT:R-DME-159050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Drosophila melanogaster)
RHEA:28544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + fluoroacetate + H(+) => fluoroacetyl-CoA + H2O
RHEA:71890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide
REACT:R-DRE-8848993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated KHDRBS1 translocates to the cytosol (Danio rerio)
RHEA:68714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-beta-elemene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-CEL-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Caenorhabditis elegans)
REACT:R-RNO-429767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Rattus norvegicus)
REACT:R-BTA-373791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Bos taurus)
REACT:R-CFA-9020255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Canis familiaris)
RHEA:65995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + hnu <=> 5,6-trans-vitamin D3
RHEA:59414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + oxaloacetate => 2-oxosuccinamate + H2O
RHEA:63678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH => CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)
REACT:R-SSC-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Sus scrofa)
REACT:R-CEL-9735946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET small tyrosine kinase inhibitors bind MET (Caenorhabditis elegans)
REACT:R-HSA-1963589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)
REACT:R-HSA-3239014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates TP53 (Homo sapiens)
RHEA:68049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-D-aspartate + S-adenosyl-L-methionine => [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine
RHEA:50365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:25777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inosose => scyllo-inosine
RHEA:61364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate
REACT:R-HSA-9676160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds NOD2 (Homo sapiens)
RHEA:19181	skos:prefLabel	"very-long-chain acyl-CoA dehydrogenase"
RHEA:19181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:19181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"very-long-chain acyl-CoA dehydrogenase"
REACT:R-DDI-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Dictyostelium discoideum)
REACT:R-HSA-197250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAMPT transfers PRIB to NAM to form NAMN (Homo sapiens)
REACT:R-XTR-5610726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The IFT-A complex recruits TULP3 (Xenopus tropicalis)
GO:0015068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine-glycine amidinotransferase activity
GO:0015068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + glycine => ornithine + guanidoacetate (Homo sapiens)
GO:0015068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine-glycine transamidinase activity
GO:0015068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine amidinotransferase activity
GO:0015068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine transamidinase activity
GO:0015068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine:glycine amidinotransferase activity
RHEA:40158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:29451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphonate = H2 + phosphate
RHEA:66293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)
REACT:R-BTA-8950766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA dimerizes (Bos taurus)
RHEA:47865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trioctanoylglycerol + H2O => dioctanoylglycerol + H(+) + octanoate
REACT:R-CEL-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Caenorhabditis elegans)
REACT:R-XTR-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Xenopus tropicalis)
REACT:R-RNO-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Rattus norvegicus)
GO:0004034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldose mutarotase activity
GO:0004034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldose 1-epimerase activity
GO:0004034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mutarotase activity
EC:1.1.1.15	skos:prefLabel	"D-iditol 2-dehydrogenase"
EC:1.1.1.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-iditol 2-dehydrogenase"
REACT:R-SPO-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Schizosaccharomyces pombe)
REACT:R-SSC-2029270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLCgamma to membrane (Sus scrofa)
RHEA:51667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-5-phenylhydantoin + H2O <=> H(+) + N-carbamoyl-D-phenylglycine
RHEA:21450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin]
GO:0086090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in SAN cell action potential
GO:0086090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in sinoatrial node cell action potential
GO:0086090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in SA node cell action potential repolarization
GO:0086090	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	voltage-gated potassium channel activity involved in sinus node cell action potential
REACT:R-XTR-5610763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Xenopus tropicalis)
RHEA:18808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-disulfide + [protein]-dithiol <=> [DsbA protein]-dithiol + [protein]-disulfide
REACT:R-DME-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Drosophila melanogaster)
REACT:R-MMU-4085133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUM (lumican) binds integrin alpha2beta1 (Mus musculus)
RHEA:47905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(acetyl)-sphing-4-enine => ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate
REACT:R-MMU-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)
REACT:R-BTA-2395340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxyallysine by LOX (Bos taurus)
REACT:R-XTR-1369052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid influx (Xenopus tropicalis)
REACT:R-SCE-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
REACT:R-MMU-8932355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades Ub-NFE2L2 (Mus musculus)
RHEA:49761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDTA + FMNH2 + O2 => ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O
RHEA:42537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(65) in tRNA => pseudouridine(65) in tRNA
RHEA:17268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-aconitate <=> cis-aconitate
GO:0102738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity
RHEA:71415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) = 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)
RHEA:30578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 menaquinone-8 + protoporphyrinogen IX <=> 3 menaquinol-8 + protoporphyrin IX
REACT:R-GGA-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Gallus gallus)
RHEA:66129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-phenylalanine => (2S)-2-aminobutanoate + 3-phenylpyruvate
RHEA:40042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 L-glutamate + N-acetyl-L-aspartate <=> 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate
GO:0086062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in Purkinje myocyte action potential
RHEA:41408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine
REACT:R-GGA-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Gallus gallus)
RHEA:29683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltohexaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltopentaose
RHEA:35005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fucose(out) => L-fucose(in)
RHEA:13706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine => alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP
REACT:R-HSA-912685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)
REACT:R-HSA-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Homo sapiens)
RHEA:31612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene => H2O + rhodopin
REACT:R-DRE-6807565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY is transferred to the phagosome (Danio rerio)
RHEA:62088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH
RHEA:12985	skos:altLabel	"glycoprotein fucosyltransferase"
RHEA:12985	skos:prefLabel	"glycoprotein 6-alpha-L-fucosyltransferase"
RHEA:12985	skos:altLabel	"guanosine diphosphofucose-glycoprotein fucosyltransferase"
RHEA:12985	skos:altLabel	"GDP-fucose--glycoprotein fucosyltransferase"
RHEA:12985	skos:altLabel	"GDP-L-fucose-glycoprotein fucosyltransferase"
RHEA:12985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
RHEA:12985	skos:altLabel	"GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase"
RHEA:12985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycoprotein 6-alpha-L-fucosyltransferase"
REACT:R-HSA-177942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EGF ligand (Homo sapiens)
REACT:R-CFA-3780994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Canis familiaris)
REACT:R-BTA-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Bos taurus)
RHEA:65187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + preaustinoid A1 <=> berkeleyone B + CO2 + H2O + succinate
REACT:R-XTR-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Xenopus tropicalis)
REACT:R-SSC-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Sus scrofa)
RHEA:30762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytosine + H(+) + H2O <=> NH4(+) + thymine
RHEA:15389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylate cyclase"
RHEA:15389	skos:altLabel	"3',5'-cyclic AMP synthetase"
RHEA:15389	skos:altLabel	"adenyl cyclase"
RHEA:15389	skos:altLabel	"ATP pyrophosphate-lyase"
RHEA:15389	skos:altLabel	"adenylyl cyclase"
RHEA:15389	skos:prefLabel	"adenylate cyclase"
RHEA:15389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP = 3',5'-cyclic AMP + diphosphate
REACT:R-RNO-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Rattus norvegicus)
RHEA:72233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in) => chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out)
REACT:R-HSA-8985644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COL1A1 gene expression is stimulated by RUNX2 and RB1 (Homo sapiens)
GO:0052689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxylate esterase activity
GO:0052689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxylic ester hydrolase activity
GO:0052689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxylic esterase activity
GO:0052689	skos:prefLabel	"Carboxylic ester hydrolases"
GO:0052689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carboxylic ester hydrolases"
GO:0052689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrolase activity acting on ester bonds
REACT:R-GGA-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Gallus gallus)
REACT:R-MMU-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
REACT:R-XTR-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Xenopus tropicalis)
RHEA:47502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => cholate + NADP(+)
RHEA:19935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + phosphate => alpha-D-glucose 1-phosphate + H2O
RHEA:44781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-9 + S-adenosyl-L-methionine => H(+) + menaquinol-9 + S-adenosyl-L-homocysteine
GO:0015575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannitol transmembrane transporter activity
GO:0015575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannitol permease activity
REACT:R-MMU-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Mus musculus)
REACT:R-HSA-376357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp7 associated Lysosome to Plasma membrane transport (Homo sapiens)
RHEA:20208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylazoxymethanol + UDP-alpha-D-glucose <=> cycasin + H(+) + UDP
GO:0033995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anhydrosialidase activity
GO:0033995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity
GO:0033995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialidase L activity
GO:0033995	skos:altLabel	"sialidase L"
GO:0033995	skos:prefLabel	"anhydrosialidase"
GO:0033995	skos:altLabel	"sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing)"
GO:0033995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoconjugate sialyl-lyase (2,7-cyclizing) activity
GO:0033995	skos:altLabel	"anhydroneuraminidase"
GO:0033995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anhydroneuraminidase activity
GO:0033995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anhydrosialidase"
RHEA:63721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	losartan + UDP-alpha-D-glucuronate => losartan-2-N-beta-D-glucuronide + UDP
RHEA:18527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanal + H(+) + NADPH => 3-methylbutanol + NADP(+)
GO:0047056	skos:altLabel	"(S)-tetrahydroberberine synthase"
GO:0047056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0047056	skos:altLabel	"(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming)"
GO:0047056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-tetrahydroberberine synthase activity
GO:0047056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-canadine synthase"
GO:0047056	skos:prefLabel	"(S)-canadine synthase"
GO:0047056	skos:altLabel	"CYP719A"
GO:0047056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity
GO:0047056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-canadine synthase activity
RHEA:56091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + globoside MSGG <=> CMP + globoside DSGG + H(+)
REACT:R-BTA-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Bos taurus)
RHEA:36071	skos:altLabel	"tuliposide-converting enzyme"
RHEA:36071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tuliposide A-converting enzyme"
RHEA:36071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-tuliposide A = D-glucose + tulipalin A
RHEA:36071	skos:altLabel	"6-O-(4 -hydroxy-2 -methylenebutyryl)-D-glucose acyltransferase (lactone-forming)"
RHEA:36071	skos:prefLabel	"tuliposide A-converting enzyme"
REACT:R-BTA-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Bos taurus)
RHEA:62776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-HSA-4551570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VANGL2 is phosphorylated in response to WNT5A (Homo sapiens)
REACT:R-CFA-191784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA Cap hypermethylation (Canis familiaris)
REACT:R-CEL-183002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Caenorhabditis elegans)
RHEA:65486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexyl hexanoate => hexan-1-ol + hexanoyl-CoA
REACT:R-PFA-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Plasmodium falciparum)
RHEA:13628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6)-dimethylallyladenine <=> 3-methyl-2-butenal + adenine + AH2
RHEA:37603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-MMU-2029459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Mus musculus)
RHEA:35997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-SSC-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Sus scrofa)
RHEA:63889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinga-4E,14Z-dienine => CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine
REACT:R-CFA-9013004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the ER membrane (Canis familiaris)
REACT:R-XTR-400037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi,Go Heterotrimeric G-protein complex dissociates (Xenopus tropicalis)
RHEA:43479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate
REACT:R-CEL-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Caenorhabditis elegans)
REACT:R-XTR-2730889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)
RHEA:37655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-DRE-2245218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates PHF8 (Danio rerio)
RHEA:60736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesal + H2O + NADP(+) = (2E,6E)-farnesoate + 2 H(+) + NADPH
GO:0015487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose:cation symporter activity
GO:0015487	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	melibiose permease activity
GO:0015487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose:monovalent cation symporter activity
RHEA:28056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + propanoyl-CoA => 2-oxobutanoate + CoA
RHEA:21761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA => (3R)-3-hydroxybutanoyl-CoA
RHEA:66603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dopamine + O2 <=> 2 dopamine quinone + 2 H2O
RHEA:45224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA
REACT:R-XTR-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Xenopus tropicalis)
RHEA:21567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an acyl-CoA <=> a 3-oxoacyl-CoA + CoA
RHEA:60321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-RNO-443986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor ACKR2 binds most inflammatory CC chemokines (Rattus norvegicus)
RHEA:10055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoate + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH
REACT:R-HSA-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Homo sapiens)
GO:0099602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter receptor regulator activity
RHEA:67613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
REACT:R-HSA-9755359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 8:class I MHC binds BECN1 (Homo sapiens)
REACT:R-BTA-2002466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of allysine by LOX (Bos taurus)
GO:0004994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth hormone-inhibiting hormone receptor activity
GO:0004994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRIF receptor activity
GO:0004994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SST receptor activity
GO:0004994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHIH receptor activity
GO:0004994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	somatostatin receptor activity
GO:0004994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	somatotrophin release inhibiting factor receptor activity
REACT:R-SSC-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Sus scrofa)
REACT:R-RNO-419002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Rattus norvegicus)
REACT:R-XTR-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Xenopus tropicalis)
RHEA:37809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA
REACT:R-DRE-1237045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Danio rerio)
REACT:R-GGA-2984226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NEK9 (Gallus gallus)
GO:0052895	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N1-acetylspermine oxidase activity
GO:0052895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity
REACT:R-RNO-870477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Rattus norvegicus)
REACT:R-SSC-5682629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Sus scrofa)
REACT:R-CFA-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Canis familiaris)
REACT:R-CFA-71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Canis familiaris)
REACT:R-CEL-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Caenorhabditis elegans)
REACT:R-BTA-8848776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates DOK1 (Bos taurus)
REACT:R-RNO-158982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Rattus norvegicus)
REACT:R-CFA-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Canis familiaris)
RHEA:71431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)
REACT:R-CEL-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Caenorhabditis elegans)
RHEA:47673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) => 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:50353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH => 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]
REACT:R-HSA-9731034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 3a tetramer binds to CAV1 (Homo sapiens)
REACT:R-MMU-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Mus musculus)
REACT:R-CEL-3000449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Caenorhabditis elegans)
REACT:R-CFA-389348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by pVav1 (Canis familiaris)
GO:0102076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta,beta-carotene-9',10'-cleaving oxygenase activity
REACT:R-RNO-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Rattus norvegicus)
RHEA:16288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-octopine + H2O + NAD(+) <=> H(+) + L-arginine + NADH + pyruvate
REACT:R-DRE-6805205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR35 binds kynurenic acid (Danio rerio)
REACT:R-SSC-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Sus scrofa)
RHEA:47133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinal + H2O + NAD(+) => 11-cis-retinoate + 2 H(+) + NADH
REACT:R-BTA-9718394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide antagonists (Bos taurus)
REACT:R-XTR-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Xenopus tropicalis)
REACT:R-SCE-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Saccharomyces cerevisiae)
REACT:R-MMU-5357776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
GO:0004875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement receptor activity
GO:0004875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anaphylatoxin receptor activity
REACT:R-DRE-844447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 senses MDP (Danio rerio)
REACT:R-HSA-3656257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
RHEA:35444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose => an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP
RHEA:30852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1-phosphate => D-glyceraldehyde + dihydroxyacetone phosphate
REACT:R-MMU-5607751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes (Mus musculus)
RHEA:37890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + small RNA 3'-end nucleotide <=> H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide
REACT:R-DME-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Drosophila melanogaster)
REACT:R-HSA-983161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Homo sapiens)
GO:0047861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity
GO:0047861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	halogenated tyrosine transaminase activity
GO:0047861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diiodotyrosine aminotransferase activity
GO:0047861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diiodotyrosine transaminase activity
GO:0047861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	halogenated tyrosine aminotransferase activity
RHEA:32777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate => (2-aminoethyl)phosphonate(out) + ATP + H2O
REACT:R-DRE-6801675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates NPM1 (Danio rerio)
RHEA:13175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + phosphate => H2O + NAD(+) + phosphonate
RHEA:16757	skos:altLabel	"N(1),N(8)-bis(glutathionyl)spermidine reductase"
RHEA:16757	skos:prefLabel	"trypanothione-disulfide reductase"
RHEA:16757	skos:altLabel	"NADPH:trypanothione oxidoreductase"
RHEA:16757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trypanothione-disulfide reductase"
RHEA:16757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + trypanothione = H(+) + NADPH + trypanothione disulfide
RHEA:16757	skos:altLabel	"trypanothione reductase"
RHEA:10965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-xylulose => ADP + D-xylulose 5-phosphate + H(+)
REACT:R-DRE-5687640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Danio rerio)
REACT:R-CFA-8858369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVRL1 binds BMP9,BMP10 (Canis familiaris)
RHEA:63002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoate + NH4(+) => (11Z,14Z,17Z)-eicosatrienamide + H2O
REACT:R-DME-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Drosophila melanogaster)
REACT:R-MMU-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Mus musculus)
REACT:R-DME-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Drosophila melanogaster)
RHEA:19879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP
REACT:R-RNO-5218818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Rattus norvegicus)
GO:0051139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal cation:proton antiporter activity
GO:0051139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal ion:hydrogen antiporter activity
GO:0051139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
GO:0051139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal ion:proton antiporter activity
GO:0004864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphatase inhibitor activity
GO:0004864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoprotein phosphatase inhibitor activity
GO:0004864	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase 2 inhibitor activity
GO:0004864	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 2A inhibitor activity
REACT:R-RNO-4641206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPOs bind LGRs (Rattus norvegicus)
REACT:R-HSA-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Homo sapiens)
REACT:R-HSA-2029452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to phosphorylated ITAMs (Homo sapiens)
REACT:R-CEL-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Caenorhabditis elegans)
REACT:R-CFA-9020261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Canis familiaris)
REACT:R-GGA-5624133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3:GTP binds the UNC119B complex (Gallus gallus)
REACT:R-SCE-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Saccharomyces cerevisiae)
RHEA:27538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde
RHEA:48947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-2855077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-3 binds to molecular patterns on the target cell surface  (Gallus gallus)
RHEA:11317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic aldoxime => a nitrile + H2O
REACT:R-HSA-2129353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin associates with microfibrils (Homo sapiens)
REACT:R-CEL-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Caenorhabditis elegans)
RHEA:20727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-saturated-(3S)-3-hydroxyacyl-CoA <=> a (3E)-enoyl-CoA + H2O
RHEA:60829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-adenosine in mRNA + H2O => a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate
REACT:R-GGA-8944218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VIII (Gallus gallus)
REACT:R-HSA-5635860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Homo sapiens)
GO:0031278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,2-galactosyltransferase activity
GO:0036426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity
REACT:R-CEL-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)
GO:0035797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAM-dependent tellurite methyltransferase activity
GO:0035797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine-dependent tellurite methyltransferase activity
GO:0035797	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tellurite methylase activity
GO:0035797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tellurite methyltransferase activity
REACT:R-BTA-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Bos taurus)
REACT:R-HSA-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Homo sapiens)
REACT:R-BTA-5624473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Bos taurus)
RHEA:39600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)
RHEA:36518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + tetracosanoyl-CoA <=> 3-oxohexacosanoyl-CoA + CO2 + CoA
RHEA:18752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + NAD(+) <=> [protein]-disulfide + H(+) + NADH
EC:1.14.15.22	skos:altLabel	"CYP105A1"
EC:1.14.15.22	skos:prefLabel	"vitamin D 1,25-hydroxylase"
EC:1.14.15.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vitamin D 1,25-hydroxylase"
RHEA:16322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-indan-1-ol + NADP(+) => H(+) + indan-1-one + NADPH
REACT:R-GGA-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Gallus gallus)
RHEA:31421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-beta-curcumene + diphosphate => (2Z,6E)-farnesyl diphosphate
REACT:R-MMU-452097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruited STAT5 is phosphorylated (Mus musculus)
REACT:R-SSC-182993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL) (Sus scrofa)
GO:0102135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity
RHEA:71094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)
REACT:R-GGA-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)
RHEA:64412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)
REACT:R-DME-5358343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT palmitoylates Hh N-terminal fragment (Drosophila melanogaster)
GO:0047769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arogenate dehydratase activity
GO:0047769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxycyclohexadienyl dehydratase activity
GO:0047769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arogenate hydro-lyase (decarboxylating)
GO:0047769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)
RHEA:57034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formate + methylamine + succinate semialdehyde => (E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O
RHEA:32088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate
REACT:R-CFA-192097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Canis familiaris)
RHEA:36755	skos:prefLabel	"UDP-Glc:alpha-D-GlcNAc-glucosaminyl-diphosphoundecaprenol beta-1,3-glucosyltransferase"
RHEA:36755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-Glc:alpha-D-GlcNAc-glucosaminyl-diphosphoundecaprenol beta-1,3-glucosyltransferase"
RHEA:36755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-MMU-2046175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further sulfation on galactose residues produces KSPG (Mus musculus)
RHEA:40991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + H2O = 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA
REACT:R-DRE-4551604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO1 (Danio rerio)
GO:0004351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate decarboxylase activity
GO:0004351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate 1-carboxy-lyase activity
GO:0004351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamic acid decarboxylase activity
GO:0004351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate alpha-decarboxylase activity
GO:0004351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamic decarboxylase activity
GO:0004351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamate decarboxylase activity
GO:0004351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
GO:0004351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteic acid decarboxylase activity
GO:0004351	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aspartic alpha-decarboxylase
GO:0004351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate-alpha-decarboxylase activity
REACT:R-SSC-5660660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p300 acetylates RELA subunit (Sus scrofa)
RHEA:69875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:61222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate
GO:0001631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysLT receptor
GO:0001631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteinyl leukotriene receptor activity
REACT:R-MMU-5687091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 binds MAPKAPK5 (Mus musculus)
REACT:R-SSC-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Sus scrofa)
RHEA:23328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal
REACT:R-RNO-72143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lariat Formation and 5'-Splice Site Cleavage (Rattus norvegicus)
RHEA:53274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagaturonate => 5-dehydro-L-gluconate
REACT:R-DRE-163664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binds to gamma subunit of AMP kinase heterotrimer (Danio rerio)
REACT:R-BTA-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Bos taurus)
RHEA:64728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate
GO:0002114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-33 receptor activity
GO:0002114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-33R
GO:0002114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-33 receptor activity
REACT:R-CEL-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Caenorhabditis elegans)
RHEA:25338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + urea = isocyanate + NH4(+)
REACT:R-GGA-140842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n fibrin monomers -> fibrin multimer (Gallus gallus)
REACT:R-SSC-4641206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPOs bind LGRs (Sus scrofa)
RHEA:39220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctacosanyol-CoA + H(+) + NADPH => (3R)-hydroxyoctacosanoyl-CoA + NADP(+)
RHEA:53282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose => D-threose
GO:0102255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neo-lambda-carrahexaose hydrolase activity
RHEA:46793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:17445	skos:altLabel	"hydrogenase (ferredoxin)"
RHEA:17445	skos:altLabel	"hydrogenase II"
RHEA:17445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin hydrogenase"
RHEA:17445	skos:altLabel	"hydrogenase"
RHEA:17445	skos:altLabel	"hydrogen-lyase"
RHEA:17445	skos:altLabel	"bidirectional hydrogenase"
RHEA:17445	skos:prefLabel	"ferredoxin hydrogenase"
RHEA:17445	skos:altLabel	"hydrogenlyase"
RHEA:17445	skos:altLabel	"uptake hydrogenase"
RHEA:17445	skos:altLabel	"hydrogenase I"
RHEA:17445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:17445	skos:altLabel	"H2 producing hydrogenase"
RHEA:17445	skos:altLabel	"H2 oxidizing hydrogenase"
RHEA:32933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin + CMP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol
RHEA:59427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylamine + H2O + O2 <=> benzaldehyde + H2O2 + NH4(+)
GO:0102991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA hydrolase activity
RHEA:71531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine(out) = guanine(in)
REACT:R-HSA-209760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Homo sapiens)
REACT:R-RNO-8849882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-4 bind reticulon 3 (Rattus norvegicus)
RHEA:18206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + progesterone => 11alpha-hydroxyprogesterone + A + H2O
REACT:R-HSA-9673296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5:FZD7 binds p-DVL (Homo sapiens)
RHEA:16364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate
RHEA:59510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(2-succinyl)-L-cysteinyl-[protein] => fumarate + L-cysteinyl-[protein]
RHEA:32862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
RHEA:58023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> eupatolide + H2O
REACT:R-MMU-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Mus musculus)
REACT:R-BTA-5668947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates myosin phosphatase (Bos taurus)
REACT:R-HSA-2426676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of laminin networks (Homo sapiens)
RHEA:26480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-demethylmenaquinol + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+)
REACT:R-DRE-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Danio rerio)
REACT:R-CFA-9027532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DHA to 13-HDHA (Canis familiaris)
RHEA:58243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] <=> ADP-D-ribose + L-cysteinyl-[protein]
RHEA:71428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)
RHEA:11082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + thymidine => dTMP + H2O
RHEA:35088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N'-monoacetylchitobiose-6'-phosphate => D-glucosamine + N-acetyl-D-glucosamine 6-phosphate
REACT:R-SSC-202365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)
REACT:R-MMU-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Mus musculus)
RHEA:68330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantetheine + phosphate => (R)-4'-phosphopantetheine + H2O
REACT:R-HSA-1299475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)
REACT:R-DRE-3149494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC:cob(II)alamin binds MMADHC (Danio rerio)
REACT:R-CFA-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Canis familiaris)
RHEA:44214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxytetradecanoyl-CoA + AMP + diphosphate => 3-hydroxytetradecanoate + ATP + CoA
GO:0050076	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maleate cis-trans-isomerase activity
GO:0050076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleate isomerase activity
REACT:R-SSC-9699578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 phosphorylates CDKN1B (Sus scrofa)
REACT:R-CFA-1630304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Canis familiaris)
REACT:R-BTA-74730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin degradation (Bos taurus)
RHEA:71841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(in) => dehydroepiandrosterone 3-sulfate(out)
REACT:R-CFA-9691421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK binds BTK inhibitors (Canis familiaris)
RHEA:28430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allose 6-phosphate = D-allulose 6-phosphate
RHEA:56180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2
REACT:R-GGA-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Gallus gallus)
REACT:R-HSA-9724685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds omalizumab (Homo sapiens)
REACT:R-BTA-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)
REACT:R-CFA-416358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) inhibits PI3K alpha (Canis familiaris)
REACT:R-CEL-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)
RHEA:25002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-phenylalanine
RHEA:10944	skos:altLabel	"pseudouridine 5'-monophosphatase"
RHEA:10944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudouridine 5'-phosphatase"
RHEA:10944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + psi-UMP = phosphate + pseudouridine
RHEA:10944	skos:prefLabel	"pseudouridine 5'-phosphatase"
RHEA:10944	skos:altLabel	"5'-PsiMPase"
REACT:R-GGA-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Gallus gallus)
REACT:R-RNO-8981093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12 bound to IL12R internalises (Rattus norvegicus)
REACT:R-SSC-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Sus scrofa)
REACT:R-DME-201423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI complexes with the Smad complex, suppressing BMP2 signalling (Drosophila melanogaster)
RHEA:50301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]
RHEA:39931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)
REACT:R-SSC-1474266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibrils (Sus scrofa)
GO:0061634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xyloside xylohydrolase
GO:0061634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-xylosidase
GO:0061634	skos:prefLabel	"alpha-D-xyloside xylohydrolase"
GO:0061634	skos:altLabel	"alpha-xylosidase"
GO:0061634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-D-xyloside xylohydrolase"
RHEA:32273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + CO2 + NADH => (2R,3S)-3-isopropylmalate + NAD(+)
RHEA:10679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate <=> 2-isopropylmaleate + H2O
RHEA:28902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + H(+)(in) <=> glycine(out) + H(+)(out)
GO:0102820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norbixin methyltransferase activity
RHEA:15731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-fructuronate + NADH => D-mannonate + NAD(+)
RHEA:48141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite
RHEA:52816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-HSA-265296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)
GO:0004529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exodeoxyribonuclease activity
REACT:R-MMU-1254248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80:YAP1 complex to the nucleus (Mus musculus)
RHEA:57450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+) => ATP + D-tyrosine + tRNA(Tyr)
REACT:R-RNO-9686980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 recruits APC/C:Cdh1 complex to SKP2 (Rattus norvegicus)
REACT:R-HSA-8987150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Homo sapiens)
REACT:R-GGA-141310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Gallus gallus)
REACT:R-XTR-5686315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Xenopus tropicalis)
REACT:R-HSA-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)
REACT:R-PFA-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Plasmodium falciparum)
RHEA:14003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glycocholate + H(+) => choloyl-CoA + glycine
REACT:R-SSC-198824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Sus scrofa)
GO:0033222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylose binding
RHEA:25060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (E)-cinnamate + H(+) + NADH + O2
REACT:R-MMU-9714477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the mitochondrial outer membrane (Mus musculus)
RHEA:54402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:65977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + hnu => previtamin D3
RHEA:36318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-CoA + 2 NADPH <=> CoA + hexadecan-1-ol + 2 NADP(+)
REACT:R-XTR-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Xenopus tropicalis)
RHEA:63503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + S-nitrosoglutathione <=> NADP(+) + sulfinamide glutathione
REACT:R-HSA-380241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)
REACT:R-SCE-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Saccharomyces cerevisiae)
REACT:R-HSA-380170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)
RHEA:69766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty aldehyde + H2O + NAD(+) <=> a medium chain fatty acid + 2 H(+) + NADH
REACT:R-DME-2424476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
RHEA:12880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylacetone + O2 <=> acetate + H(+) + methylglyoxal
RHEA:45287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-eicosanoyl-sphing-4-enine
REACT:R-MMU-5696119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Mus musculus)
RHEA:34396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine => L-beta-phenylalanine
REACT:R-CFA-212007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1 4-hydroxylate atRA (Canis familiaris)
RHEA:25632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin + S-adenosyl-L-methionine <=> H(+) + laricitrin + S-adenosyl-L-homocysteine
RHEA:65275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin C + H(+) + NADPH + O2 <=> chrodrimanin H + H2O + NADP(+)
REACT:R-SSC-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Sus scrofa)
REACT:R-XTR-2466106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BGN binds Collagen types I, VI, (IX) (Xenopus tropicalis)
RHEA:33702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-RNO-6786058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL4-bound IL4R1 (Rattus norvegicus)
REACT:R-XTR-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Xenopus tropicalis)
RHEA:59267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-HSA-1980065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 stimulates HEY transcription (Homo sapiens)
REACT:R-SSC-9026408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Sus scrofa)
REACT:R-GGA-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Gallus gallus)
RHEA:39685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+) => 3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidinol phosphate aminotransferase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazolylacetolphosphate transaminase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidinol-phosphate transaminase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine:imidazoleacetol phosphate transaminase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazole acetol-phosphate transaminase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidinol-phosphate aminotransferase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidinol phosphate aminotransferase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazoleacetol phosphate transaminase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazolylacetolphosphate aminotransferase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IAP transaminase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic-imidazoleacetol phosphate transaminase activity
GO:0004400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidinol-phosphate:2-oxoglutarate aminotransferase activity
REACT:R-HSA-8948583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-17 microRNA binds CNOT6L mRNA (Homo sapiens)
RHEA:31832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => delta-guaiene + diphosphate
RHEA:42228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + A = AH2 + estrone
REACT:R-DDI-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Dictyostelium discoideum)
GO:0047846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxynucleotide 3'-phosphatase activity
GO:0047846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleotide 3'-phosphohydrolase activity
GO:0047846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-deoxynucleotidase activity
GO:0047846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-deoxyribonucleotidase activity
REACT:R-MMU-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Mus musculus)
REACT:R-CEL-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Caenorhabditis elegans)
RHEA:38488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)
RHEA:60948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + S-adenosyl-L-methionine = (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Mus musculus)
REACT:R-BTA-4085347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO1 (Bos taurus)
REACT:R-RNO-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Rattus norvegicus)
REACT:R-DRE-1475032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Danio rerio)
REACT:R-DRE-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Danio rerio)
RHEA:69942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:61727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-glucoside + NAD(+) <=> a 3-dehydro-D-glucoside + H(+) + NADH
REACT:R-RNO-171106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex => LDLR + LDL (Rattus norvegicus)
RHEA:49252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-fructose 1-phosphate(in) + L-histidyl-[protein]
RHEA:49252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--D-fructose phosphotransferase"
RHEA:49252	skos:altLabel	"fructose PTS permease"
RHEA:49252	skos:prefLabel	"protein-N(pi)-phosphohistidine--D-fructose phosphotransferase"
REACT:R-SSC-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Sus scrofa)
REACT:R-HSA-8950057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB1 binds TYK2 (Homo sapiens)
RHEA:28153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + spermidine <=> CoA + H(+) + N(1)-acetylspermidine
RHEA:57127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate <=> 2-hydroxy-5-oxoproline
REACT:R-GGA-6784628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)
REACT:R-RNO-8848751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds AKT1 (Rattus norvegicus)
REACT:R-DDI-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Dictyostelium discoideum)
REACT:R-DRE-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Danio rerio)
RHEA:63210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + glyoxal
RHEA:37197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphate + CoA => octadecanoyl-CoA + sn-glycerol 3-phosphate
REACT:R-BTA-8851888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds SHC1-2 (Bos taurus)
RHEA:59717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaono-1,5-lactone + H2O => D-maltopentaonate + H(+)
RHEA:60458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cUAMP + 2 diphosphate => ATP + UTP
REACT:R-DME-9708466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y486 BACH1 translocates from the nucleoplasm to the cytosol (Drosophila melanogaster)
REACT:R-XTR-3858495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits GTP-bound RHOA (Xenopus tropicalis)
GO:0008641	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	small protein activating enzyme activity
GO:0008641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like modifier activating enzyme activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme B12-dependent diol dehydrase activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-2,3-butanediol dehydrase activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanediol dehydratase activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylcobalamin-dependent diol dehydratase activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diol dehydrase activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diol dehydratase activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DL-1,2-propanediol hydro-lyase activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propanediol dehydrase activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dioldehydratase activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propane-1,2-diol hydro-lyase (propanal-forming)
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-propanediol dehydratase activity
GO:0050215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propane-1,2-diol hydro-lyase activity
REACT:R-DRE-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Danio rerio)
RHEA:65422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP(out) + NAD(+)(in) => GMP(in) + NAD(+)(out)
REACT:R-DRE-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Danio rerio)
RHEA:18129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoaldehyde + H2O + NADP(+) = a 2-oxocarboxylate + 2 H(+) + NADPH
RHEA:18129	skos:altLabel	"alpha-ketoaldehyde dehydrogenase"
RHEA:18129	skos:prefLabel	"2-oxoaldehyde dehydrogenase (NADP(+))"
RHEA:18129	skos:altLabel	"methylglyoxal dehydrogenase"
RHEA:18129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoaldehyde dehydrogenase (NADP(+))"
RHEA:16396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juvenile hormone II <=> H(+) + juvenile hormone II carboxylate + methanol
REACT:R-DRE-176585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Danio rerio)
RHEA:57187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + methylglyoxal <=> S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]
RHEA:30561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + H(+) + triphosphate => GTP + H2O
GO:0043176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amine binding
REACT:R-HSA-381412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP2 binds IGF forming IGF:IGFBP2 (Homo sapiens)
GO:1902388	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane ceramide 1-phosphate transfer activity
GO:1902388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide 1-phosphate transfer activity
GO:1902388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTPD1 transports C1P from plasma membrane to Golgi membrane (Homo sapiens)
GO:1902388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide 1-phosphate carrier activity
GO:1902388	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ceramide 1-phosphate transporter activity
REACT:R-XTR-9611751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1,2-agonists bind ADRB1,2 (Xenopus tropicalis)
RHEA:68861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxo-25-hydroxycholesterol + H(+) + NADPH => 7beta-25-dihydroxycholesterol + NADP(+)
REACT:R-MMU-352119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Mus musculus)
RHEA:71746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + hexanedioate(in) <=> 2-oxoglutarate(in) + hexanedioate(out)
REACT:R-CFA-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)
REACT:R-HSA-5210947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)
GO:0030790	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity
GO:0030790	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	halogenated phenol O-methyltransferase activity
GO:0030790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophenol O-methyltransferase activity
GO:0030790	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trichlorophenol O-methyltransferase activity
RHEA:18207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11alpha-hydroxyprogesterone + A + H2O => AH2 + O2 + progesterone
REACT:R-SSC-6786720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DECR2 reduces LCtE-CoA to t3enoyl-CoA (Sus scrofa)
REACT:R-BTA-193068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates PREG (Bos taurus)
REACT:R-SSC-2160931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of tight junctions (Sus scrofa)
GO:0008227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled amine receptor activity
GO:0008227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amine receptor activity, G-protein coupled
GO:0008227	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	biogenic amine receptor
GO:0008227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled amine receptor activity
REACT:R-HSA-177920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2 to GAB1 (Homo sapiens)
REACT:R-CFA-975097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)
REACT:R-RNO-5654159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds PLCG1 (Rattus norvegicus)
REACT:R-HSA-9024881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Homo sapiens)
REACT:R-MMU-113429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongating transcript encounters a lesion in the template (Mus musculus)
RHEA:49545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O => 2-dehydro-3-deoxy-D-gluconate + NH4(+)
REACT:R-DRE-5687121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPKAPK5 phosphorylates HSPB1 (Danio rerio)
RHEA:25360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-BTA-427645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A3 cotransports Pi, 2Na+ (Bos taurus)
RHEA:29465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K(+)(out) => K(+)(in)
REACT:R-SSC-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Sus scrofa)
RHEA:11752	skos:altLabel	"aspirin esterase"
RHEA:11752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylsalicylate + H2O = acetate + H(+) + salicylate
RHEA:11752	skos:prefLabel	"acetylsalicylate deacetylase"
RHEA:11752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylsalicylate deacetylase"
GO:0050045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity
GO:0050045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laminaribiose phosphorylase activity
RHEA:57041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-apiose => D-apiofuranose
REACT:R-BTA-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Bos taurus)
GO:0050291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine N-acyltransferase activity
GO:0050291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingosine N-acyltransferase"
GO:0050291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:sphingosine N-acyltransferase activity
GO:0050291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide synthase activity
GO:0050291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ceramide synthetase activity
GO:0050291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphingosine acyltransferase activity
GO:0050291	skos:prefLabel	"sphingosine N-acyltransferase"
GO:0050291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+)
GO:0050291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide synthase activity
RHEA:44833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + tetradecanoyl-CoA => CoA + O-tetradecanoyl-(R)-carnitine
REACT:R-RNO-9667456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B bind desmopressin (Rattus norvegicus)
RHEA:36732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-nitrocyclohexan + NADP(+) => 1-nitrocyclohexene + H(+) + NADPH
REACT:R-GGA-352914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Gallus gallus)
REACT:R-DME-214393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)
REACT:R-BTA-2186771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 binds SMAD7 (Bos taurus)
REACT:R-RNO-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Rattus norvegicus)
GO:1905058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels
GO:1905058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration
REACT:R-HSA-5637764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)
REACT:R-HSA-1989758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of UGT1A9 (Homo sapiens)
GO:0047848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dephospho-[reductase kinase] kinase activity
GO:0047848	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	reductase kinase activity
GO:0047848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP-activated protein kinase kinase activity
GO:0047848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP-activated kinase activity
GO:0047848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase kinase kinase activity
GO:0047848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK30
GO:0047848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity
GO:0047848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dephospho-reductase kinase kinase activity
GO:0047848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme A reductase kinase kinase activity
GO:0047848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity
REACT:R-BTA-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Bos taurus)
REACT:R-DRE-5655170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 monoubiquitinates POLH (Danio rerio)
RHEA:30387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-D-glucose phosphorylase"
RHEA:30387	skos:altLabel	"GDP-L-galactose phosphorylase"
RHEA:30387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase"
RHEA:30387	skos:prefLabel	"GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase"
RHEA:30387	skos:prefLabel	"GDP-D-glucose phosphorylase"
RHEA:30387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)
RHEA:15697	skos:altLabel	"(2S)-flavanone 2-hydroxylase"
RHEA:15697	skos:prefLabel	"licodione synthase"
RHEA:15697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"licodione synthase"
RHEA:15697	skos:altLabel	"CYP93B1"
RHEA:15697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]
REACT:R-PFA-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Plasmodium falciparum)
REACT:R-HSA-169904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)
REACT:R-CEL-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Caenorhabditis elegans)
RHEA:14566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-MMU-5607722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK phosphorylates IKKA dimer (Mus musculus)
RHEA:15735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2 => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O
REACT:R-XTR-3222593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B demethylates H3K27me3 on p16INK4A promoter (Xenopus tropicalis)
REACT:R-SSC-5654714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
RHEA:70557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + N-acetyl-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O
REACT:R-DDI-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Dictyostelium discoideum)
REACT:R-DRE-975594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLB1 hydrolyses RPALM to atROL (Danio rerio)
REACT:R-DME-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Drosophila melanogaster)
RHEA:44474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine
REACT:R-CEL-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Caenorhabditis elegans)
REACT:R-HSA-6804191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the PRDM1 gene (Homo sapiens)
REACT:R-XTR-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Xenopus tropicalis)
GO:0010347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactose-1-phosphate phosphatase activity
REACT:R-SCE-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Saccharomyces cerevisiae)
RHEA:48683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH
REACT:R-HSA-6801808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A,REG3G binds bacterial peptidoglycan (Homo sapiens)
REACT:R-HSA-9038545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-613 binds to the 3'UTR of the NR1H3 mRNA (Homo sapiens)
RHEA:30596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + FADH2 + O2 => 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O
RHEA:32409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2S,4S)-neoisodihydrocarveol + NAD(+)
RHEA:31324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)
REACT:R-HSA-198266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
RHEA:34827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 = H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)
GO:0005452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:inorganic anion antiporter activity
GO:0005452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic anion exchanger activity
REACT:R-MMU-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Mus musculus)
REACT:R-DME-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Drosophila melanogaster)
REACT:R-XTR-983703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-SYK phosphorylates BLNK (SLP65) (Xenopus tropicalis)
REACT:R-GGA-5654662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)
RHEA:27530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(3S,6E)-nerolidol synthase"
RHEA:27530	skos:altLabel	"nerolidol synthase"
RHEA:27530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate
RHEA:27530	skos:altLabel	"(3S)-(E)-nerolidol synthase"
RHEA:27530	skos:altLabel	"(E)-nerolidol synthase"
RHEA:27530	skos:prefLabel	"(3S,6E)-nerolidol synthase"
REACT:R-HSA-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Homo sapiens)
RHEA:59288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O = D-glucose + sphing-4-enine
REACT:R-DME-1605591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Drosophila melanogaster)
RHEA:54678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-HSA-4551571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds ROR2 and VANGL2 (Homo sapiens)
REACT:R-DME-5358340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoproteolytic cleavage of Hh precursors (Drosophila melanogaster)
RHEA:28854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose(in) + Na(+)(in) <=> melibiose(out) + Na(+)(out)
RHEA:29588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH
REACT:R-DDI-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Dictyostelium discoideum)
REACT:R-BTA-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Bos taurus)
RHEA:52369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + cholesterol => adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)
RHEA:22488	skos:prefLabel	"S-(hydroxymethyl)glutathione synthase"
RHEA:22488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-(hydroxymethyl)glutathione synthase"
RHEA:22488	skos:altLabel	"glutathione-dependent formaldehyde-activating enzyme"
RHEA:22488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(hydroxymethyl)glutathione = formaldehyde + glutathione
GO:0043744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylaminoadipate kinase activity
GO:0043744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[LysW]-aminoadipate kinase
GO:0043744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2-acetyl-L-aminoadipate kinase activity
GO:0043744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylaminoadipate kinase activity
GO:0043744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-aminoadipate 5-phosphotransferase activity
RHEA:61780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-tagatose = keto-L-sorbose
RHEA:66972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose = alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)
RHEA:66972	skos:prefLabel	"dTDP-Rha:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-rahmnosyltransferase"
RHEA:66972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-Rha:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-rahmnosyltransferase"
EC:1.14.19.75	skos:prefLabel	"very-long-chain acyl-lipid omega-9 desaturase"
EC:1.14.19.75	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"very-long-chain acyl-lipid omega-9 desaturase"
RHEA:60115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-(indol-3-yl)lactoyl-CoA <=> (E)-3-(indol-3-yl)acryloyl-CoA + H2O
REACT:R-SSC-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Sus scrofa)
REACT:R-MMU-388808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-2 monomer (Mus musculus)
RHEA:49239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein](out) + sucrose <=> L-histidyl-[protein] + sucrose 6(G)-phosphate(in)
RHEA:42647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] <=> diphosphate + holo-[malonate decarboxylase ACP]
REACT:R-DRE-9025999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Danio rerio)
RHEA:59061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + H2O => (20S)-ginsenoside Rh2 + D-glucose
REACT:R-XTR-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Xenopus tropicalis)
REACT:R-MMU-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Mus musculus)
REACT:R-RNO-9627106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) forms dimer (Rattus norvegicus)
RHEA:54090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,5-trihydroxyphenylacetate + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + H(+) + NADH + O2
RHEA:32510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-isopropenyl-7-methyloxepan-2-one + H2O <=> 6-hydroxy-3-isopropenylheptanoate + H(+)
REACT:R-DRE-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Danio rerio)
REACT:R-CFA-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)
RHEA:63382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
REACT:R-HSA-3928648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate NGEF (Homo sapiens)
GO:0001066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plastid single subunit type RNA polymerase activity
RHEA:56528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + D-tryptophan + FADH2 + O2 = 6-chloro-D-tryptophan + FAD + 2 H2O
REACT:R-HSA-2454192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Allergen dependent IgE bound FCERI aggregation (Homo sapiens)
RHEA:24884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-glutamate + NADPH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+)
RHEA:35268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol(in) => ethanol(out)
RHEA:14516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine <=> ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate
REACT:R-PFA-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Plasmodium falciparum)
GO:0034931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxypyrene methyltransferase activity
RHEA:69900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + thymidine(out) => 2 Na(+)(in) + thymidine(in)
RHEA:71700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-phenylalanyl-L-leucine(out) => H(+)(in) + L-phenylalanyl-L-leucine(in)
RHEA:46911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol
GO:0140657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis-dependent activity
GO:0140657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase activity, coupled
GO:0140657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase activity
GO:0140657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent activity
GO:0140657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-dependent activity
REACT:R-MMU-176517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to PREG (Mus musculus)
REACT:R-SSC-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Sus scrofa)
RHEA:54205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine
REACT:R-GGA-9707659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes:LY96 activates TLR4 (Gallus gallus)
REACT:R-HSA-5653786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)
REACT:R-SCE-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Saccharomyces cerevisiae)
REACT:R-HSA-201515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK recruits PI3K (Homo sapiens)
REACT:R-DDI-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Dictyostelium discoideum)
RHEA:64878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphate + UMP => H2O + UDP
EC:2.7.1.213	skos:prefLabel	"cytidine kinase"
EC:2.7.1.213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytidine kinase"
REACT:R-MMU-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Mus musculus)
REACT:R-HSA-8943040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF polyubiquitinates monoubiquitinated PCNA (Homo sapiens)
REACT:R-DDI-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)
REACT:R-DRE-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Danio rerio)
REACT:R-MMU-158354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Mus musculus)
EC:3.2.1.8	skos:prefLabel	"endo-1,4-beta-xylanase"
EC:3.2.1.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endo-1,4-beta-xylanase"
REACT:R-XTR-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Xenopus tropicalis)
RHEA:23155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H(+) + NADH <=> a ubiquinol + NAD(+)
RHEA:27525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxypyridine + O2 <=> H(+) + N-formylmaleamate
RHEA:63714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:34237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite => 4-nitro-6-oxohepta-2,4-dienedioate
RHEA:44150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta-lysine => L-lysine
REACT:R-CEL-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Caenorhabditis elegans)
GO:0042803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein homodimerization activity
GO:0042803	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dimerization activity
RHEA:31982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + trimethylamine <=> H2O + NADP(+) + trimethylamine N-oxide
REACT:R-MMU-6784399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Mus musculus)
RHEA:37201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate
RHEA:31003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"germanicol synthase"
RHEA:31003	skos:prefLabel	"germanicol synthase"
RHEA:31003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = germanicol
RHEA:55695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphoceramide + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)
REACT:R-DRE-168412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP elicits a NOD2 response (Danio rerio)
REACT:R-MMU-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Mus musculus)
RHEA:68509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (Z)-beta-farnesene + diphosphate
REACT:R-GGA-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Gallus gallus)
RHEA:52112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
REACT:R-DRE-9029680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-7 translocates to the nucleus (Danio rerio)
RHEA:34732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine
REACT:R-BTA-69891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of CHEK2 by ATM (Bos taurus)
REACT:R-RNO-191072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Cx43 (Rattus norvegicus)
GO:0102084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa O-methyltransferase activity
RHEA:58277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 ATP => cyclic hexaadenylate + 6 diphosphate
REACT:R-CFA-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Canis familiaris)
RHEA:64543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base
GO:0050604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxadiene 5-alpha-hydroxylase activity
GO:0050604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxadiene 5alpha-hydroxylase activity
GO:0050604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)
GO:0050604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxadiene 5a-hydroxylase activity
REACT:R-MMU-159101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Mus musculus)
RHEA:67129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH => (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)
RHEA:52124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O
REACT:R-RNO-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Rattus norvegicus)
REACT:R-GGA-9611851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 bind ADR,NAd (Gallus gallus)
RHEA:57631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate <=> H2O + ML-236C carboxylate
REACT:R-BTA-9648949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A antagonists bind HTR3A pentamer (Bos taurus)
REACT:R-HSA-9737111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protonated weak acid translocates across the plasma membrane (Homo sapiens)
RHEA:67669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-DRE-5334854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAR:RXR binds SUMO-CRABP2:atRA (Danio rerio)
RHEA:15247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + glycerol + H(+) => a monoacylglycerol + H2O
EC:3.4.21.88	skos:prefLabel	"repressor LexA"
EC:3.4.21.88	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"repressor LexA"
RHEA:67474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine => H2O + succinyl-CoA
REACT:R-HSA-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Homo sapiens)
REACT:R-MTU-936655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite results from reduction of APS (Mycobacterium tuberculosis)
REACT:R-HSA-174916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of N-glucuronides (Homo sapiens)
REACT:R-DRE-5577234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Danio rerio)
RHEA:42176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:15596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amicoumacin A 2-phosphate + H2O <=> amicoumacin A + phosphate
REACT:R-DDI-203553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS binds NOSIP (Dictyostelium discoideum)
RHEA:17842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP
REACT:R-MMU-209566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is auto-ubiquitinated (Mus musculus)
REACT:R-CEL-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Caenorhabditis elegans)
RHEA:35249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O
REACT:R-DRE-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Danio rerio)
REACT:R-HSA-6797810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAPL1 (Homo sapiens)
REACT:R-SSC-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Sus scrofa)
RHEA:22914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + L-alanine => L-valine + pyruvate
REACT:R-SSC-5678313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Sus scrofa)
RHEA:31768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
REACT:R-BTA-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
REACT:R-DRE-5654643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)
REACT:R-BTA-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Bos taurus)
REACT:R-HSA-879770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DEC2 (BHLHE41, BHLHB3) (Homo sapiens)
GO:0050138	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate hydroxylase activity
GO:0050138	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate:NADP+ 6-oxidoreductase (hydroxylating)
GO:0050138	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinic acid hydroxylase activity
GO:0050138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate dehydrogenase activity
REACT:R-SSC-432897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ILK interacts with beta-1 integrin (Sus scrofa)
RHEA:48356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
REACT:R-SSC-158750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Sus scrofa)
REACT:R-CFA-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)
RHEA:57442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 2-methylanisole + O2 + reduced [NADH--hemoprotein reductase]
RHEA:20007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + D-glucuronate => an alpha-D-glucuronoside + H2O
RHEA:32549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,5R)-sabinene + diphosphate => (2E)-geranyl diphosphate
REACT:R-SSC-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Sus scrofa)
REACT:R-XTR-1606602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Xenopus tropicalis)
REACT:R-SSC-2533950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP14, TMPRSS6 (Sus scrofa)
REACT:R-DME-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Drosophila melanogaster)
GO:0019788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RUB1 conjugating enzyme activity
GO:0019788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Hub1 conjugating enzyme activity
GO:0019788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
GO:0019788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 transferase activity
GO:0019788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NEDD8 conjugating enzyme activity
REACT:R-DRE-373700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-9 binds DCC:DIP13alpha complex (Danio rerio)
REACT:R-BTA-6801808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A,REG3G binds bacterial peptidoglycan (Bos taurus)
REACT:R-SSC-5654631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PPTN11 (Sus scrofa)
REACT:R-DME-5690046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT2 hydrolyses PALMCoA to PALM (Drosophila melanogaster)
REACT:R-HSA-351913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of TJP1 (Homo sapiens)
GO:0047599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coformycin:NADP+ 8-oxidoreductase activity
GO:0047599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxocoformycin reductase activity
GO:0047599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	8-ketodeoxycoformycin reductase activity
REACT:R-HSA-549129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations into hepatic cells (Homo sapiens)
REACT:R-SSC-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Sus scrofa)
RHEA:18463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA
RHEA:16860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
GO:0102990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-n-alk(en)ylresorcinol O-methyltransferase activity
REACT:R-GGA-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Gallus gallus)
REACT:R-CFA-139917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAX protein (Canis familiaris)
GO:0005127	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ciliary neurotrophic factor receptor ligand
GO:0005127	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ciliary neurotrophic factor
GO:0005127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ciliary neurotrophic factor receptor binding
GO:0033435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUA codon-amino acid adaptor activity
GO:0033435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATA codon-amino acid adaptor activity
GO:0033435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoleucine tRNA
RHEA:18915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate
REACT:R-MMU-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Mus musculus)
REACT:R-GGA-9678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 binds S1PR1 agonists (Gallus gallus)
REACT:R-MMU-193401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
REACT:R-MMU-9667965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds PP2A (Mus musculus)
REACT:R-HSA-9663785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol (Homo sapiens)
RHEA:28951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-arabinose(in) = H(+)(out) + L-arabinose(out)
REACT:R-SSC-982810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation (Sus scrofa)
REACT:R-HSA-3209109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA (Homo sapiens)
REACT:R-BTA-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Bos taurus)
REACT:R-BTA-1358789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Self-ubiquitination of RNF41 (Bos taurus)
REACT:R-CFA-72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of mRNA at the 3'-end (Canis familiaris)
REACT:R-CFA-430021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)
REACT:R-SSC-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Sus scrofa)
REACT:R-CFA-2730903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of TRAF6 (Canis familiaris)
RHEA:63568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-casomorphin-7 + H2O = beta-casomorphin-6 + L-isoleucine
REACT:R-SSC-8865107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MICAL1 produces NADP+, H2O2 (Sus scrofa)
RHEA:69210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate
RHEA:67419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5662620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds cadmium (Bos taurus)
REACT:R-MMU-8938431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 and BTN1A1 binds periplakin (PPL) (Mus musculus)
REACT:R-SSC-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)
RHEA:70908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)
RHEA:48531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GP1c (d18:1(4E)) + H2O <=> ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate
EC:2.4.1.71	skos:prefLabel	"arylamine glucosyltransferase"
EC:2.4.1.71	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arylamine glucosyltransferase"
EC:2.4.1.71	skos:altLabel	"UDP glucose-arylamine glucosyltransferase"
RHEA:50318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + H(+) + octadecanoate => ethyl octadecanoate + H2O
RHEA:57914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-glutaminyl-tRNA(Gln) + phosphate => 5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+)
EC:1.1.1.375	skos:altLabel	"lactate/malate dehydrogenase"
EC:1.1.1.375	skos:prefLabel	"L-2-hydroxycarboxylate dehydrogenase [NAD(P)(+)]"
EC:1.1.1.375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-2-hydroxycarboxylate dehydrogenase [NAD(P)(+)]"
REACT:R-RNO-5683735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
REACT:R-BTA-8873923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 binds LPCAT1 and PC (Bos taurus)
RHEA:34208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-alpha-D-glucosyl-L-rhamnose + phosphate => beta-D-glucose 1-phosphate + L-rhamnopyranose
REACT:R-CEL-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Caenorhabditis elegans)
REACT:R-SSC-74220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Sus scrofa)
REACT:R-RNO-5610752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R translocates to the nucleus (Rattus norvegicus)
RHEA:38982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-RNO-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Rattus norvegicus)
REACT:R-HSA-5669023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TWEAK binds FN14 (Homo sapiens)
REACT:R-BTA-3002811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates PLK1 (Bos taurus)
GO:0140936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2B deubiquitinase activity
GO:0140936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H2B deubiquitination
REACT:R-XTR-3249378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING recruits TBK1 and STAT6 (Xenopus tropicalis)
REACT:R-GGA-5358340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoproteolytic cleavage of Hh precursors (Gallus gallus)
RHEA:48389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
REACT:R-HSA-6810464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT14 hydrolyses UDP-Glc to G1P and UMP (Homo sapiens)
REACT:R-SPO-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Schizosaccharomyces pombe)
REACT:R-XTR-5695989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD11 dehydrogenates BH-CoA (Xenopus tropicalis)
REACT:R-CFA-8864125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Canis familiaris)
REACT:R-DME-3000112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Drosophila melanogaster)
RHEA:59601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methoxytryptamine + H2O + O2 => 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)
REACT:R-MMU-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Mus musculus)
REACT:R-RNO-174660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Rattus norvegicus)
GO:1990053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-5-methylcytosine glycosylase activity
RHEA:67491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:28339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinyl-CoA => crotonobetainyl-CoA + H2O
REACT:R-MMU-3965447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein subunits dissociate from WNT:FZD complex (Mus musculus)
REACT:R-SSC-189384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLVRA:Zn2+, BLVRB reduce BV to BIL (Sus scrofa)
REACT:R-GGA-5618110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Gallus gallus)
RHEA:62727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide C + FADH2
REACT:R-HSA-8981622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin:oxygen dissociates (Homo sapiens)
REACT:R-BTA-8937191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Bos taurus)
REACT:R-RNO-8863804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Rattus norvegicus)
EC:3.1.3.3	skos:prefLabel	"phosphoserine phosphatase"
EC:3.1.3.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoserine phosphatase"
RHEA:56363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-deoxycarminomycin + H(+) + NADPH + O2 <=> 13-dihydrocarminomycin + H2O + NADP(+)
REACT:R-RNO-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Rattus norvegicus)
REACT:R-DRE-8948231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)
REACT:R-DRE-9757688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDN (Danio rerio)
REACT:R-DRE-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Danio rerio)
RHEA:14213	skos:altLabel	"fructose 1-phosphate kinase"
RHEA:14213	skos:prefLabel	"1-phosphofructokinase"
RHEA:14213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)
RHEA:14213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-phosphofructokinase"
REACT:R-DDI-9641109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Dictyostelium discoideum)
RHEA:31008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => beta-amyrin
RHEA:34050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'''-deamino-6'''-hydroxyneomycin C + O2 <=> 6'''-deamino-6'''-oxoneomycin C + H2O2
REACT:R-DRE-1678998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosomal TLRs pass through the Golgi (Danio rerio)
RHEA:13340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucurono-6,2-lactone + H2O <=> D-glucuronate + H(+)
RHEA:56345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-hydroxyisoflavone + UDP-alpha-D-glucose => a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-CEL-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Caenorhabditis elegans)
REACT:R-RNO-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Rattus norvegicus)
REACT:R-DRE-5696220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to arsenite(3-) (Danio rerio)
REACT:R-BTA-6805103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates TP53 (Bos taurus)
REACT:R-DDI-8854604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D16 accelerates GTP hydrolysis by RAB4A (Dictyostelium discoideum)
RHEA:23262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+)
RHEA:41825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexanoyl-[ACP] + NADP(+)
REACT:R-XTR-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Xenopus tropicalis)
RHEA:29771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate(in) + ATP + H2O = ADP + arsenate(out) + H(+) + phosphate
GO:0140381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxytryptamine 4-phosphate methyltransferase activity
GO:0140381	skos:prefLabel	"psilocybin synthase"
GO:0140381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine = 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine
GO:0140381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norbaeocystin methyltransferase
GO:0140381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	psilocybin synthase
GO:0140381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"psilocybin synthase"
REACT:R-DRE-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Danio rerio)
RHEA:32656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + eugenol + NADP(+) => a coniferyl ester + NADPH
RHEA:33960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + neomycin C => 6'''-deamino-6'''-oxoneomycin C + L-glutamate
RHEA:58539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoylglycine
REACT:R-BTA-6799431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds HIPK1 (Bos taurus)
REACT:R-DRE-9029561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to the ABCA1 promoter (Danio rerio)
RHEA:64775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol
RHEA:38188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Bos taurus)
REACT:R-DRE-1566962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by elastin-degrading extracellular proteinases (Danio rerio)
REACT:R-HSA-9708517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)
RHEA:40149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + eicosanoate + H(+) => eicosanoyl-CoA + H2O
RHEA:10411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA <=> 3-oxopristanoyl-CoA + CoA
RHEA:17924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NAD(+) <=> D-xylulose + H(+) + NADH
RHEA:61666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+) => (2E,6E,10E)-geranylgeraniol + ATP
RHEA:61975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:30335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + H2O = NH4(+) + UTP
REACT:R-BTA-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Bos taurus)
REACT:R-SPO-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Schizosaccharomyces pombe)
RHEA:63689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)
REACT:R-DME-3769391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 binds the beta-catenin:CBY complex (Drosophila melanogaster)
GO:0043724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-keto-3-deoxygalactonate aldolase activity
GO:0043724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDGal aldolase activity
RHEA:20723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopenicillin N + phenylacetyl-CoA <=> CoA + H(+) + L-2-aminoadipate + penicillin G
REACT:R-HSA-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Homo sapiens)
REACT:R-MMU-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Mus musculus)
RHEA:60449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted glutathione + H2O => glycine + S-substituted gamma-glutamyl-L-cysteine
REACT:R-CFA-2028294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Canis familiaris)
RHEA:22878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelate + NH4(+) => (R)-mandelamide + H2O
REACT:R-HSA-380311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Plk1 to centrosomes (Homo sapiens)
RHEA:31573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + NADP(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2
REACT:R-HSA-6786118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL13 binds IL13RA:TYK2 (Homo sapiens)
REACT:R-HSA-376126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM binds Netrin-1 (Homo sapiens)
GO:0044605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphocholine transferase activity
RHEA:72693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(in) => 17beta-estradiol 17-O-(beta-D-glucuronate)(out)
RHEA:63472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-hexaprenol + ATP = ADP + all-trans-hexaprenyl phosphate + H(+)
RHEA:47480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + NADP(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
REACT:R-RNO-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Rattus norvegicus)
REACT:R-CFA-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Canis familiaris)
RHEA:12240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)
RHEA:12240	skos:altLabel	"MSAS"
RHEA:12240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-methylsalicylic acid synthase"
RHEA:12240	skos:altLabel	"6-MSAS"
RHEA:12240	skos:prefLabel	"6-methylsalicylic acid synthase"
REACT:R-XTR-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Xenopus tropicalis)
REACT:R-CFA-2130725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)
REACT:R-HSA-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Homo sapiens)
REACT:R-HSA-9652580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Homo sapiens)
REACT:R-DRE-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Danio rerio)
RHEA:35640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate
REACT:R-DRE-164620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Danio rerio)
RHEA:40335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SSC-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Sus scrofa)
REACT:R-CFA-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Canis familiaris)
REACT:R-SPO-8875902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC45A3 transports Glc from extracellular region to cytosol (Schizosaccharomyces pombe)
REACT:R-XTR-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Xenopus tropicalis)
RHEA:36593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloroacrylate + H(+) + NADPH => (S)-2-chloropropanoate + NADP(+)
RHEA:40732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + 2 H2O => (20S)-protopanaxadiol + 2 D-glucose
REACT:R-HSA-2213244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides (Homo sapiens)
RHEA:47935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + H2O + NAD(+) <=> (2S)-3-sulfolactate + 2 H(+) + NADH
REACT:R-RNO-9700200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)
REACT:R-HSA-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)
RHEA:11826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O
REACT:R-HSA-426522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nonendonucleolytic RISC binds exactly matching target RNAs (Homo sapiens)
RHEA:71387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate(in) + Na(+)(in) = L-pipecolate(out) + Na(+)(out)
GO:0001594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trace-amine receptor activity
REACT:R-GGA-9021072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC7, ZDHHC21 palmitoylate ESR1 (Gallus gallus)
RHEA:17427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + CO2 + NADPH => CoA + NADP(+) + pyruvate
RHEA:10046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanone + H(+) + NADH => cyclohexanol + NAD(+)
REACT:R-BTA-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Bos taurus)
RHEA:40968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)
RHEA:68773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => diphosphate + germacrene C
REACT:R-SSC-2213235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of nonameric complex in the endocytic pathway (Sus scrofa)
RHEA:50485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]
RHEA:22513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + precorrin-8X => hydrogenobyrinate
REACT:R-RNO-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Rattus norvegicus)
RHEA:63713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)
RHEA:40988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDTA + 2 FMNH2 + 2 O2 => ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O
REACT:R-HSA-9761812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD (Homo sapiens)
REACT:R-BTA-1855202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Bos taurus)
RHEA:11400	skos:prefLabel	"sordaricin 6-deoxyaltrosyltransferase"
RHEA:11400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-6-deoxy-alpha-D-altrose + sordaricin = 4'-O-demethylsordarin + GDP + H(+)
RHEA:11400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sordaricin 6-deoxyaltrosyltransferase"
REACT:R-DDI-71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)
GO:0102183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenastenone reductase activity
REACT:R-HSA-159843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
REACT:R-CFA-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Canis familiaris)
REACT:R-MMU-2684507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2, 4, (3) bind FGF2 (Mus musculus)
RHEA:18516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + O2 <=> D-mannose + H2O2
REACT:R-CFA-975142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Canis familiaris)
REACT:R-BTA-751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gz complex dissociates (Bos taurus)
GO:0102505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigeninidin 5-O-glucosyltransferase activity
RHEA:19305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA
RHEA:19305	skos:prefLabel	"2,3',4,6-tetrahydroxybenzophenone synthase"
RHEA:19305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3',4,6-tetrahydroxybenzophenone synthase"
REACT:R-DRE-8937631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Danio rerio)
RHEA:72573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + pentanoate(in) => dehydroepiandrosterone 3-sulfate(in) + pentanoate(out)
REACT:R-CEL-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Caenorhabditis elegans)
REACT:R-RNO-5658438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRED dimer binds NF1 (Rattus norvegicus)
REACT:R-HSA-5676940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Homo sapiens)
RHEA:32382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,4S)-limonene-1,2-diol + NAD(+) <=> (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH
RHEA:53700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
RHEA:17988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanal + H2O + NAD(+) <=> 4-(trimethylamino)butanoate + 2 H(+) + NADH
RHEA:11288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromacarpine + H(+) + O2 = H2O2 + macarpine
RHEA:48979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + pyocyanin
RHEA:61117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O => ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate
REACT:R-CFA-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Canis familiaris)
REACT:R-SSC-5138441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A-FZD4 recruits DVL2 (Sus scrofa)
REACT:R-DDI-5693578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDP1 and TDP2 process unligatable DSB ends (Dictyostelium discoideum)
RHEA:57759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
REACT:R-HSA-5693536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDC1 (Homo sapiens)
RHEA:55131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-5-methylhexanoyl-[ACP] <=> (2E)-5-methylhexenoyl-[ACP] + H2O
RHEA:12398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-D-galacturonate + 3 H(+) + 2 NADPH => dTDP-D-galactose + H2O + 2 NADP(+)
REACT:R-SPO-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)
REACT:R-GGA-2396009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds c-di-GMP (Gallus gallus)
REACT:R-PFA-6786652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIT1 hydrolyses CHIT to 3xADGP (Plasmodium falciparum)
EC:1.1.-.-	skos:prefLabel	"Acting on the CH-OH group of donors"
EC:1.1.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on the CH-OH group of donors"
RHEA:30052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetate + H2O => fluoride + glycolate + H(+)
REACT:R-DDI-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)
REACT:R-RNO-1592349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14 (MT1-MMP) binds TIMP2 (Rattus norvegicus)
RHEA:40277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenedioyl-CoA + H2O2 => hexadecanedioyl-CoA + O2
RHEA:41287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetradecanoylsphing-4-enine = sphing-4-enine + tetradecanoate
REACT:R-XTR-9638090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Xenopus tropicalis)
REACT:R-HSA-9632918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Homo sapiens)
GO:0031800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 3 metabotropic glutamate receptor binding
GO:0031800	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 3 metabotropic glutamate receptor ligand
REACT:R-SSC-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Sus scrofa)
REACT:R-DME-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)
RHEA:39570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:50833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate
GO:0102162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity
GO:0102162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal
GO:0102162	skos:altLabel	"8'-apo-beta-carotenal 15,15'-oxygenase"
GO:0102162	skos:prefLabel	"all-trans-8'-apo-beta-carotenal 15,15'-oxygenase"
GO:0102162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-8'-apo-beta-carotenal 15,15'-oxygenase"
REACT:R-HSA-2485180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MII catalyses GDP/GTP exchange on Gt (Homo sapiens)
REACT:R-CEL-70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Caenorhabditis elegans)
REACT:R-CFA-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Canis familiaris)
GO:0050299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:streptomycin 3''-phosphotransferase activity
GO:0050299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	streptomycin 3''-kinase (phosphorylating)
GO:0050299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	streptomycin 3''-kinase activity
GO:0050299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	streptomycin 3''-phosphotransferase activity
RHEA:72309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(out) + taurocholate(in) => L-glutamate(in) + taurocholate(out)
RHEA:41065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:19864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16alpha-hydroxysteroid + NAD(+) <=> a 16-oxosteroid + H(+) + NADH
REACT:R-HSA-187746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIT/RIN are activated (Homo sapiens)
RHEA:23765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-serine => H(+) + O-phospho-L-serine + phosphate
RHEA:38210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Danio rerio)
REACT:R-CFA-5693356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEMIP hydrolyses HA (Canis familiaris)
REACT:R-BTA-379395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates 3MT to HVA (Bos taurus)
RHEA:50230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + FAD + H(+) + H2O => FADH2 + O2 + resorcinol
RHEA:40141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + CoA + H(+) => (9Z)-octadecenoyl-CoA + H2O
REACT:R-GGA-265862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with BRCA2 (Gallus gallus)
REACT:R-SSC-193072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)
REACT:R-CEL-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
REACT:R-HSA-8862771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G2A binds bacterial phospholipids (Homo sapiens)
REACT:R-HSA-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
REACT:R-CFA-3221982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANP binds TP53 (Canis familiaris)
REACT:R-CFA-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Canis familiaris)
RHEA:57326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein]
RHEA:65462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexyl acetate => acetyl-CoA + hexan-1-ol
REACT:R-DRE-201443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II receptor phosphorylates type I receptor (Danio rerio)
REACT:R-CFA-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Canis familiaris)
REACT:R-SSC-5617829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of IFT A complex (Sus scrofa)
REACT:R-MMU-2076392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcA to heparan (Mus musculus)
RHEA:64604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UTP = diphosphate + uridylyl-L-seryl-[protein]
RHEA:58728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine in rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine
RHEA:30120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-[ACP] + H2O => dodecanoate + H(+) + holo-[ACP]
RHEA:30507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinone-8 + H(+) + NADH = 2-demethylmenaquinol-8 + NAD(+)
REACT:R-SSC-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Sus scrofa)
RHEA:28792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + NAD(+) => H(+) + NADH + thymine
REACT:R-SSC-8951951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds EP300 (Sus scrofa)
REACT:R-BTA-2395324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyrrole cross-links (Bos taurus)
RHEA:58795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Fe(III)-petrobactin(out) + H2O <=> ADP + Fe(III)-petrobactin(in) + H(+) + phosphate
GO:0004514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate mononucleotide pyrophosphorylase (carboxylating)
GO:0004514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0004514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	QAPRTase activity
GO:0004514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinolinic phosphoribosyltransferase activity
GO:0004514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinolinic acid phosphoribosyltransferase activity
GO:0004514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD pyrophosphorylase activity
GO:0004514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
GO:0004514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinolinate phosphoribosyltransferase (decarboxylating) activity
GO:0004514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate-nucleotide pyrophosphorylase (carboxylating) activity
REACT:R-BTA-8951595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Bos taurus)
RHEA:68358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + N-acetyl-L-aspartate => H2O + N-acetyl-L-aspartyl-L-glutamate
REACT:R-HSA-109813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1 binds SOS1 (Homo sapiens)
REACT:R-XTR-3900070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MKL1 with SUMO1 (Xenopus tropicalis)
REACT:R-HSA-5607722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK phosphorylates IKKA dimer (Homo sapiens)
REACT:R-DRE-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Danio rerio)
REACT:R-DRE-2396337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Danio rerio)
REACT:R-MMU-5654163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds PLCG1 (Mus musculus)
REACT:R-DRE-140748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Danio rerio)
RHEA:14111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+)
REACT:R-HSA-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Homo sapiens)
REACT:R-CEL-193763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)
REACT:R-BTA-198440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Bos taurus)
REACT:R-XTR-388468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR1A,B (Xenopus tropicalis)
REACT:R-MMU-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Mus musculus)
RHEA:39732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Rattus norvegicus)
REACT:R-SSC-210426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamate synaptic vesicle docking and priming (Sus scrofa)
REACT:R-MMU-5623643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH13 reduces atRAL to atROL (Mus musculus)
RHEA:13559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathione + H(+) + phosphate => ATP + gamma-L-glutamyl-L-cysteine + glycine
RHEA:24375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] <=> H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine
REACT:R-RNO-9023632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)
REACT:R-SSC-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Sus scrofa)
RHEA:54209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O
RHEA:70696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + glycine(out) + 3 Na(+)(out) => chloride(in) + glycine(in) + 3 Na(+)(in)
RHEA:21221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa + O2 => 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)
RHEA:64651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH
RHEA:40976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O => 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine
RHEA:43393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 1,3-bisphosphate + phosphate
REACT:R-MMU-8943780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 recruits NuRD to PTEN gene (Mus musculus)
GO:0004131	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocytosine deaminase activity
GO:0004131	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytosine aminohydrolase activity
GO:0004131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine deaminase activity
RHEA:34707	skos:prefLabel	"alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase"
RHEA:34707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane
RHEA:34707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase"
RHEA:18286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-aspartate + H2O => a carboxylate + D-aspartate
RHEA:34268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + fumigaclavine B => CoA + fumigaclavine A
REACT:R-HSA-8950173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ADP-ribosylation factor 1 (Homo sapiens)
REACT:R-HSA-6794346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind NLGNs (Homo sapiens)
REACT:R-MMU-419841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Light stimulates opsin receptors (Mus musculus)
REACT:R-RNO-140748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Rattus norvegicus)
REACT:R-CFA-73912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Canis familiaris)
REACT:R-GGA-430076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds 14-3-3-zeta (Gallus gallus)
REACT:R-DME-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Drosophila melanogaster)
RHEA:27633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylene glycol + NAD(+) <=> glycolaldehyde + H(+) + NADH
REACT:R-GGA-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Gallus gallus)
GO:0008478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal phosphokinase activity
GO:0008478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal 5-phosphate-kinase activity
GO:0008478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:pyridoxal 5'-phosphotransferase activity
GO:0008478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin B6 kinase activity
GO:0008478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin B(6) kinase activity
GO:0008478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal kinase (phosphorylating)
GO:0008478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxine kinase activity
GO:0008478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal kinase activity
GO:0008478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine kinase activity
RHEA:44894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP => an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose
RHEA:63073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + orcinol
REACT:R-DME-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Drosophila melanogaster)
REACT:R-HSA-9694389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3 is glycosylated (Homo sapiens)
RHEA:55099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxypentanoyl-CoA + H2O <=> (3S)-3-hydroxypentanoate + CoA + H(+)
REACT:R-RNO-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Rattus norvegicus)
RHEA:55827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1),7(1)-dihydroxybacteriochlorophyllide d <=> a bacteriochlorophyllide f + H2O
RHEA:53528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-CFA-3296309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR3 binds HCAR3 ligands (Canis familiaris)
RHEA:54508	skos:prefLabel	"beta-geranylfarnesene synthase"
RHEA:54508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-geranylfarnesene synthase"
RHEA:54508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate = beta-heptaprene + diphosphate
REACT:R-HSA-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Homo sapiens)
RHEA:28831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate(in) + H(+)(in) = D-gluconate(out) + H(+)(out)
REACT:R-DME-191062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of Klotho-bound FGFR1c (Drosophila melanogaster)
REACT:R-GGA-5654169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 (Gallus gallus)
RHEA:55800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SSC-5656105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Sus scrofa)
REACT:R-RNO-176664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + PAPS => estrone 3-sulfate + PAP (Rattus norvegicus)
REACT:R-GGA-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Gallus gallus)
REACT:R-HSA-9731031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 6 binds to NPIPB3 (Homo sapiens)
RHEA:40741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside C-Y + 2 D-glucose => (20S)-ginsenoside Rb2 + 2 H2O
RHEA:69147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O + O2 <=> 4-guanidinobutanal + H2O2 + NH4(+)
REACT:R-GGA-6790487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 ubiquitinates SUMOylated XPC (Gallus gallus)
RHEA:48549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O => [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol
RHEA:67220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH
REACT:R-GGA-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Gallus gallus)
RHEA:66649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => african-3-ene + diphosphate
RHEA:67395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-ATP + H2O <=> 2-oxo-AMP + diphosphate + H(+)
RHEA:17436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + choline <=> AH2 + betaine aldehyde
REACT:R-HSA-6794336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMDAR binds PSD-95 subfamily members (Homo sapiens)
REACT:R-BTA-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)
REACT:R-XTR-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Xenopus tropicalis)
REACT:R-SSC-173597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose is oxidised to UDP-glucuronate (Sus scrofa)
RHEA:65719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a primary linear alkyl sulfate ester + O2 <=> an aldehyde + CO2 + H(+) + succinate + sulfate
REACT:R-CFA-2025724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Canis familiaris)
RHEA:45839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:44786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-10 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-10 + S-adenosyl-L-methionine
RHEA:47469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA
RHEA:31732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O
REACT:R-DRE-193703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta is activated (Danio rerio)
RHEA:22039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + D-glucose <=> [phosphate](n-1) + D-glucose 6-phosphate + H(+)
REACT:R-HSA-180687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Ran-GDP to Ran-GTP (Homo sapiens)
REACT:R-MMU-9708104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE5A dimer binds PDE5A inhibitors (Mus musculus)
REACT:R-SSC-77591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Sus scrofa)
RHEA:21453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 => a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical
RHEA:41986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + H(+) + NADH => NAD(+) + propan-2-ol
RHEA:41850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADPH
REACT:R-HSA-176664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + PAPS => estrone 3-sulfate + PAP (Homo sapiens)
REACT:R-HSA-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Homo sapiens)
REACT:R-HSA-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Homo sapiens)
GO:0052890	skos:prefLabel	"With a flavin as acceptor"
GO:0052890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
GO:0052890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a flavin as acceptor"
REACT:R-SSC-9634861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT2 (Sus scrofa)
REACT:R-GGA-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Gallus gallus)
RHEA:11990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine
RHEA:28990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N-acetylneuraminate(in) <=> H(+)(out) + N-acetylneuraminate(out)
RHEA:51303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-phenylalanine <=> H2O + N-(9Z-octadecenoyl)-L-phenylalanine
RHEA:56691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 <=> (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate
REACT:R-SSC-5654571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS3 (Sus scrofa)
REACT:R-HSA-202472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TRAF6 to CBM complex (Homo sapiens)
REACT:R-CFA-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Canis familiaris)
RHEA:20933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythrulose 1-phosphate => dihydroxyacetone phosphate + formaldehyde
REACT:R-HSA-74707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IRS to insulin receptor (Homo sapiens)
RHEA:64264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrochrysone carboxylate + H(+) = atrochrysone + CO2
RHEA:52491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:20134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(indol-3-yl)lactate + NAD(+) => H(+) + indole-3-pyruvate + NADH
REACT:R-CFA-173483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAMBI interferes with the interaction of type I receptor with type II receptor (Canis familiaris)
RHEA:41034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA
GO:0016903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0016903	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors
REACT:R-SCE-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Saccharomyces cerevisiae)
RHEA:49881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-deoxycarminomycin + H(+) + NADPH + O2 => 13-dihydrocarminomycin + H2O + NADP(+)
RHEA:52668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH
RHEA:52668	skos:prefLabel	"[amino-group carrier protein]-5-phospho-L-glutamate reductase"
RHEA:52668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[amino-group carrier protein]-5-phospho-L-glutamate reductase"
REACT:R-CFA-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Canis familiaris)
RHEA:53009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate => di-trans,poly-cis-polyprenyl diphosphate + n diphosphate
REACT:R-RNO-2046239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular KSPG translocates to the lysosome for degradation (Rattus norvegicus)
GO:0102713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A25 hydroxylase activity
RHEA:44817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-12 + CO2 + diphosphate
EC:2.-.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferases"
EC:2.-.-.-	skos:prefLabel	"Transferases"
REACT:R-SCE-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Saccharomyces cerevisiae)
REACT:R-BTA-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Bos taurus)
RHEA:25291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD(+) => acetaldehyde + H(+) + NADH
REACT:R-SPO-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Schizosaccharomyces pombe)
REACT:R-RNO-9706312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to LCK (Rattus norvegicus)
GO:0097644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitonin family binding
RHEA:40509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O
REACT:R-BTA-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Bos taurus)
REACT:R-BTA-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Bos taurus)
RHEA:60322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine
REACT:R-MMU-8877311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB31 GEFs exchange GTP for GDP on RAB31 (Mus musculus)
REACT:R-BTA-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Bos taurus)
RHEA:11189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-cyano-L-alanine + 2 H2O => L-aspartate + NH4(+)
RHEA:51355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-serine <=> (9Z)-octadecenoate + L-serine
RHEA:45000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 3-hydroxybutanoyl-CoA = CoA + O-3-hydroxybutanoyl-(R)-carnitine
REACT:R-BTA-2187388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Bos taurus)
REACT:R-XTR-9700662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Xenopus tropicalis)
REACT:R-CFA-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Canis familiaris)
RHEA:37668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP
REACT:R-MMU-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)
RHEA:30587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + dimethyl sulfoxide = 2-demethylmenaquinone-8 + dimethyl sulfide + H2O
RHEA:44617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)
REACT:R-CFA-2161660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGE2 by PTGES (Canis familiaris)
REACT:R-RNO-109823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Rattus norvegicus)
RHEA:31687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate
RHEA:32430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-isodihydrocarvone + A <=> (S)-carvone + AH2
REACT:R-BTA-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Bos taurus)
REACT:R-GGA-199910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates ATF1 (Gallus gallus)
REACT:R-HSA-5662647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT4 binds copper (Homo sapiens)
RHEA:19792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(dimethylamino)azobenzene + H2O + NADP(+) <=> 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH
RHEA:45219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] <=> Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
RHEA:31425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-alpha-cedrene + diphosphate => (2Z,6E)-farnesyl diphosphate
RHEA:17449	skos:prefLabel	"flaviolin linalyltransferase"
RHEA:17449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate
RHEA:17449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flaviolin linalyltransferase"
REACT:R-DDI-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Dictyostelium discoideum)
REACT:R-DRE-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Danio rerio)
RHEA:67436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-DDI-109671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Dictyostelium discoideum)
RHEA:32094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine <=> dTDP + erythromycin D + H(+)
REACT:R-SCE-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Saccharomyces cerevisiae)
REACT:R-DRE-9753676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1,2 acetylate APAP-Cys to APAP-Mer (Danio rerio)
REACT:R-GGA-2453863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRA6 transports atROL from extracellular region to cytosol (Gallus gallus)
REACT:R-DME-109699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
REACT:R-DME-4085372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO2,3 (Drosophila melanogaster)
REACT:R-SSC-444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR5 binds CXCL13 (Sus scrofa)
RHEA:28616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methylbutanenitrile + H2O => (1Z,2S)-2-methylbutanal oxime
RHEA:51642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2
RHEA:23050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + acetoacetate => (S)-3-hydroxybutanoate + 2-oxoglutarate
REACT:R-GGA-2132283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to host cell surface (Gallus gallus)
REACT:R-DRE-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Danio rerio)
RHEA:17406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine => H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine
REACT:R-HSA-376200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A10-mediated uptake of small neutral amino acids (Homo sapiens)
RHEA:62827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)
GO:0033777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP3A10
GO:0033777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate 6beta-hydroxylase activity
GO:0033777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	6beta-hydroxylase activity
GO:0033777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity
GO:0033777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lithocholate 6beta-monooxygenase activity
GO:0033777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity
REACT:R-SCE-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Saccharomyces cerevisiae)
REACT:R-BTA-8983996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Bos taurus)
RHEA:36731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-alkenal reductase (NADP(+))"
RHEA:36731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-nitrocyclohexan + NADP(+) = 1-nitrocyclohexene + H(+) + NADPH
RHEA:36731	skos:prefLabel	"2-alkenal reductase (NADP(+))"
RHEA:36731	skos:altLabel	"NADPH-dependent alkenal/one oxidoreductase"
GO:0004758	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	serine palmitoyltransferase
GO:0004758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SPT
GO:0004758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine C-palmitoyltransferase activity
GO:0004758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:serine C-2 acyltransferase decarboxylating
GO:0004758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity
GO:0004758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxosphinganine synthetase activity
REACT:R-MMU-9707977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Mus musculus)
REACT:R-SCE-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Saccharomyces cerevisiae)
GO:0004474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate transacetase activity
GO:0004474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate synthetase activity
GO:0004474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malic-condensing enzyme activity
GO:0004474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malic synthetase activity
GO:0004474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylic transacetase activity
GO:0004474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate transacetylase activity
GO:0004474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate condensing enzyme activity
GO:0004474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-malate glyoxylate-lyase (CoA-acetylating) activity
GO:0004474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate synthase activity
GO:0004474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
RHEA:44549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:70368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + octanoyl-CoA => CoA + H(+) + N-octanoyl-3-oxosphinganine
GO:0018710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone carboxylase activity
GO:0018710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetone:carbon-dioxide ligase (AMP-forming)
RHEA:70427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phenylacetyl-CoA = 2-phenylacetate + CoA + H(+)
REACT:R-SSC-420595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-2:Nectin 3 trans heterodimer interaction (Sus scrofa)
RHEA:25900	skos:prefLabel	"6-phospho-3-hexuloisomerase"
RHEA:25900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-phospho-3-hexuloisomerase"
RHEA:25900	skos:altLabel	"3-hexulose-6-phosphate isomerase"
RHEA:25900	skos:altLabel	"phospho-3-hexuloisomerase"
RHEA:25900	skos:altLabel	"PHI"
RHEA:25900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabino-hex-3-ulose 6-phosphate = beta-D-fructose 6-phosphate
RHEA:25900	skos:altLabel	"6-phospho-3-hexulose isomerase"
RHEA:20487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Danio rerio)
RHEA:10363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydrocoumarin + H2O <=> 3-(2-hydroxyphenyl)propanoate + H(+)
RHEA:19201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + ATP = ADP + dGMP + H(+)
REACT:R-HSA-5251942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hikeshi binds HSP70s:ATP (Homo sapiens)
REACT:R-MMU-9686521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2:CCNA phosphorylates TERF2 (Mus musculus)
REACT:R-MMU-913451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3RB is phosphorylated on Ser-585 (Mus musculus)
REACT:R-XTR-204873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shp2 (Xenopus tropicalis)
REACT:R-MMU-9706319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA (Mus musculus)
RHEA:68154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + CoA => a 1,3-diacylglycerol + a fatty acyl-CoA
RHEA:52317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)
RHEA:53963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 <=> 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O
REACT:R-RNO-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)
REACT:R-SSC-183055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to EGFR (Sus scrofa)
REACT:R-MMU-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Mus musculus)
RHEA:23204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorogenate + D-glucarate = 2-O-caffeoylglucarate + L-quinate
RHEA:23204	skos:prefLabel	"chlorogenate--glucarate O-hydroxycinnamoyltransferase"
RHEA:23204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorogenate--glucarate O-hydroxycinnamoyltransferase"
RHEA:27439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione amide disulfide + 2 H2O => 2 glutathione amide + H2O2
REACT:R-RNO-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Rattus norvegicus)
REACT:R-RNO-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Rattus norvegicus)
REACT:R-RNO-2453863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRA6 transports atROL from extracellular region to cytosol (Rattus norvegicus)
REACT:R-XTR-111289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)
RHEA:14655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 5'-phosphate + H(+) => a nucleoside 3',5'-cyclic phosphate + H2O
REACT:R-RNO-1112755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds IL6ST (Rattus norvegicus)
REACT:R-RNO-389491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two NPFF receptors can bind neuropeptide FF (Rattus norvegicus)
GO:0160009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone decrotonylase activity
REACT:R-XTR-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Xenopus tropicalis)
REACT:R-MMU-77594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Mus musculus)
REACT:R-RNO-373738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin interacts with syntenin-1 (Rattus norvegicus)
RHEA:21196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate
RHEA:33011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Homo sapiens)
REACT:R-RNO-198609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)
RHEA:38493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + glycerol + H(+) => 2-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-SSC-71010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUT isomerises L-MM-CoA to SUCC-CoA (Sus scrofa)
RHEA:26421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal
RHEA:62597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH
RHEA:36258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O
RHEA:18853	skos:altLabel	"mesotartrate dehydrogenase"
RHEA:18853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tartrate dehydrogenase"
RHEA:18853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + tartrate = 2-hydroxy-3-oxosuccinate + H(+) + NADH
RHEA:18853	skos:prefLabel	"tartrate dehydrogenase"
REACT:R-HSA-9036289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
REACT:R-HSA-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Homo sapiens)
RHEA:34279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,poly-cis-dolichol + NADP(+) = di-trans,cis-polyprenol + H(+) + NADPH
RHEA:34279	skos:prefLabel	"polyprenol reductase"
RHEA:34279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polyprenol reductase"
RHEA:32269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + succinate semialdehyde => 4-aminobutanoate + glyoxylate
REACT:R-DRE-4641253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 ubiquitinates FZD to promote its downregulation (Danio rerio)
REACT:R-RNO-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Rattus norvegicus)
REACT:R-XTR-380316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of NuMA with microtubules (Xenopus tropicalis)
RHEA:15452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 <=> 4-maleylacetoacetate + H(+)
RHEA:27543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde
RHEA:41768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) = CMP + ganglioside GT1a (d18:1(4E)) + H(+)
RHEA:31840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose
RHEA:27595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 5 diphosphate
RHEA:22451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pseudouridine <=> ADP + H(+) + psi-UMP
REACT:R-XTR-5690740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds B-cell receptor (Xenopus tropicalis)
REACT:R-DRE-8878054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 (Danio rerio)
REACT:R-MMU-201515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK recruits PI3K (Mus musculus)
EC:5.4.3.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-lysine 5,6-aminomutase"
EC:5.4.3.4	skos:altLabel	"adenosylcobalamin-dependent D-lysine 5,6-aminomutase"
EC:5.4.3.4	skos:altLabel	"D-alpha-lysine mutase"
EC:5.4.3.4	skos:prefLabel	"D-lysine 5,6-aminomutase"
RHEA:27519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphing-4-enine 1-phosphate => phosphate + sphing-4-enine
REACT:R-HSA-6810161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA3 chromatin is activated (Homo sapiens)
REACT:R-DRE-71275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + glycine => ornithine + guanidoacetate (Danio rerio)
REACT:R-XTR-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Xenopus tropicalis)
REACT:R-CFA-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Canis familiaris)
GO:0005153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-8 receptor binding
GO:0005153	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-8
GO:0005153	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-8 receptor ligand
RHEA:40350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanedioyl-CoA + CoA <=> acetyl-CoA + dodecanedioyl-CoA
REACT:R-MMU-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)
REACT:R-CFA-983700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds the activated BCR (Canis familiaris)
REACT:R-DRE-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Danio rerio)
RHEA:11994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + L-1-piperideine-6-carboxylate => L-pipecolate + O2
RHEA:18998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + phosphocholine => CDP-choline + diphosphate
EC:4.6.1.16	skos:prefLabel	"tRNA-intron lyase"
EC:4.6.1.16	skos:altLabel	"tRNA splicing endonuclease"
EC:4.6.1.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-intron lyase"
RHEA:12418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acryloyl-CoA + NH4(+) => beta-alanyl-CoA
RHEA:11190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NH4(+) => 3-cyano-L-alanine + 2 H2O
REACT:R-DRE-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Danio rerio)
EC:6.5.1.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3'-phosphate/5'-hydroxy nucleic acid ligase"
EC:6.5.1.8	skos:prefLabel	"3'-phosphate/5'-hydroxy nucleic acid ligase"
REACT:R-RNO-417908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY1 binds ADP (Rattus norvegicus)
RHEA:38671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate(in) = sphinganine 1-phosphate(out)
RHEA:15417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH
REACT:R-SSC-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Sus scrofa)
RHEA:21494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + CO2 => 2,3-dihydroxybenzoate + H(+)
REACT:R-RNO-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-GGA-5654641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)
RHEA:29646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaose + H2O <=> alpha-D-glucose + D-maltohexaose
REACT:R-DRE-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Danio rerio)
RHEA:25507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> beta-phellandrene + diphosphate
RHEA:14453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(phosphooxy)-L-threonine + NAD(+) = (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH
REACT:R-BTA-5333051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA1 binds HSF1 (Bos taurus)
RHEA:22459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + H2O <=> sarcosine + urea
REACT:R-HSA-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Homo sapiens)
RHEA:66330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine(in) => taurine(out)
RHEA:50326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:14434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA precursor + ATP + 2 CTP => a tRNA with a 3' CCA end + 3 diphosphate
GO:0080069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity
REACT:R-XTR-388829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)
RHEA:70279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + stachyose = D-galactose + raffinose
REACT:R-HSA-1169402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of E2 conjugating enzymes (Homo sapiens)
REACT:R-SPO-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Schizosaccharomyces pombe)
REACT:R-BTA-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Bos taurus)
REACT:R-XTR-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Xenopus tropicalis)
REACT:R-GGA-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)
REACT:R-RNO-8869603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A13 transports NCA from extracellular region to cytosol (Rattus norvegicus)
RHEA:40375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
REACT:R-SSC-193143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates TEST to EST17b (Sus scrofa)
RHEA:37940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate
RHEA:56946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + A + H2O => AH2 + D-ribulose 5-phosphate
GO:0106322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(hydroxymethyl)glutathione dehydrogenase NAD activity
GO:0106322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione
GO:0102119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A20 carboxyl methyltransferase activity
REACT:R-RNO-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Rattus norvegicus)
REACT:R-RNO-2046285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The keratan chain can be capped by N-acetylneuraminic acid (Rattus norvegicus)
REACT:R-CEL-9603984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Caenorhabditis elegans)
REACT:R-MMU-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)
REACT:R-RNO-8852337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds TP53 (Rattus norvegicus)
REACT:R-GGA-3108209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO1 (Gallus gallus)
RHEA:36392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + NADP(+) => desmosterol + H(+) + NADPH
REACT:R-GGA-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Gallus gallus)
REACT:R-RNO-8869607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NAR to yield NAMN (Rattus norvegicus)
REACT:R-GGA-2022396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-43) (Gallus gallus)
REACT:R-RNO-6786110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL13-bound IL13R type II (Rattus norvegicus)
RHEA:15543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIMBOA beta-D-glucoside + H(+) + UDP => DIMBOA + UDP-alpha-D-glucose
REACT:R-CEL-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)
REACT:R-RNO-9748983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6MP, forming 6MeMP (Rattus norvegicus)
RHEA:64508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine
REACT:R-DRE-8964333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Danio rerio)
GO:0035240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine binding
RHEA:42882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermine
GO:0019151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose 1-dehydrogenase activity
GO:0019151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactose dehydrogenase activity
GO:0019151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-galactose dehydrogenase activity
GO:0019151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent D-galactose dehydrogenase activity
GO:0019151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactose:NAD+ 1-oxidoreductase activity
GO:0019151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose 1-dehydrogenase activity
RHEA:59783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine
REACT:R-MMU-1475422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPS is phosphorylated by cGMP-dependant protein kinase II (Mus musculus)
RHEA:45399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-8934819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)
REACT:R-DRE-177927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to EGF:EGFR:GRB2:GAB1 (Danio rerio)
REACT:R-HSA-5684862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Homo sapiens)
REACT:R-HSA-9008877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2:CBFB binds BGLAP gene promoter (Homo sapiens)
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-kappa binding
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-alpha binding
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-tau binding
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I interferon binding
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-zeta binding
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-alpha/beta binding
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-epsilon binding
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-beta binding
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I IFN binding
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-delta binding
GO:0019962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-omega binding
RHEA:47057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-SCE-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Saccharomyces cerevisiae)
RHEA:41329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate
RHEA:22209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)
RHEA:17732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + cholesterol <=> a cholesterol ester + CoA
REACT:R-SSC-201628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at DSVD (85) (Sus scrofa)
RHEA:18167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl + H(+) + NADH + O2
REACT:R-CFA-432110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Canis familiaris)
RHEA:14331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphooxypyruvate + L-glutamate => 2-oxoglutarate + O-phospho-L-serine
REACT:R-GGA-1112690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds CBL (Gallus gallus)
REACT:R-RNO-166214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion flip-flops to the opposite surface (Rattus norvegicus)
REACT:R-HSA-8983425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
REACT:R-BTA-9617927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO4 binds ATXN3 (Bos taurus)
REACT:R-HSA-194796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botB LC cleaves target cell VAMP2 (Homo sapiens)
RHEA:17730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + cholesterol => a cholesterol ester + CoA
REACT:R-BTA-6805546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I binds keratin type II (Bos taurus)
RHEA:43706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + tetradecanoyl-AMP => ATP + H(+) + tetradecanoate
REACT:R-XTR-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Xenopus tropicalis)
RHEA:18692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
REACT:R-GGA-2396399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillins bind BMPs (Gallus gallus)
RHEA:13621	skos:prefLabel	"(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase"
RHEA:13621	skos:altLabel	"malto-oligosyltrehalose synthase"
RHEA:13621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose
RHEA:13621	skos:altLabel	"maltodextrin alpha-D-glucosyltransferase"
RHEA:13621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase"
RHEA:13621	skos:altLabel	"(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase"
REACT:R-DRE-9707586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM oxidises LDL,HDL (Danio rerio)
REACT:R-BTA-5626962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB2L1 binds IKKA:IKKB:NEMO (Bos taurus)
REACT:R-CFA-9647999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCE1 cleaves S-Farn proRAS proteins (Canis familiaris)
RHEA:39821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O => docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-DRE-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Danio rerio)
REACT:R-DRE-204779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang1 (Danio rerio)
REACT:R-HSA-8944599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-93 microRNA binds PTEN mRNA (Homo sapiens)
RHEA:53423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine <=> H(+) + roseoflavin + S-adenosyl-L-homocysteine
REACT:R-HSA-442291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV2 is a GEF for Rho/Rac family kinases (Homo sapiens)
REACT:R-XTR-1295621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL dissociates from ubiquitinated p-SPRY2 (Xenopus tropicalis)
RHEA:21594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-2-aminopentanoate + NADH + pyruvate => (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+)
GO:0010329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	auxin efflux facilitator
GO:0010329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	auxin efflux carrier
GO:0010329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	auxin efflux transmembrane transporter activity
REACT:R-MMU-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Mus musculus)
REACT:R-HSA-9027532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DHA to 13-HDHA (Homo sapiens)
RHEA:16832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + O2 <=> a carboxylate + H(+) + H2O2
REACT:R-BTA-450690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Bos taurus)
REACT:R-CFA-163843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-GAS6 to GAS6 (Canis familiaris)
RHEA:60408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine
REACT:R-BTA-917807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Bos taurus)
RHEA:45361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(11Z-eicosenoyl)-sphinganine => (11Z)-eicosenoate + sphinganine
RHEA:51383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + dopamine <=> CoA + H(+) + N-(9Z-octadecanoyl)-dopamine
REACT:R-DRE-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)
REACT:R-MMU-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Mus musculus)
REACT:R-GGA-166721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Gallus gallus)
REACT:R-GGA-450690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Gallus gallus)
REACT:R-RNO-202165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)
RHEA:63135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin <=> cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione
RHEA:58942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopaoctaene + diphosphate + NAD(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADH
RHEA:13722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + testololactone => H(+) + testolate
REACT:R-HSA-1655846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Mevalonate Kinase (MVK) (Homo sapiens)
RHEA:23988	skos:altLabel	"LL-diaminopimelate transaminase"
RHEA:23988	skos:altLabel	"LL-DAP aminotransferase"
RHEA:23988	skos:altLabel	"LL-DAP-AT"
RHEA:23988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate
RHEA:23988	skos:prefLabel	"LL-diaminopimelate aminotransferase"
RHEA:23988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"LL-diaminopimelate aminotransferase"
REACT:R-BTA-3788725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C complex binds EHMT1:EHMT2 (Bos taurus)
RHEA:32407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S,4S)-neoisodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH
REACT:R-BTA-9731590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)
GO:0005042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	netrin receptor activity
RHEA:64634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyl acetate + CoA => acetyl-CoA + butan-1-ol
REACT:R-DRE-3900070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MKL1 with SUMO1 (Danio rerio)
RHEA:21636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP
RHEA:21636	skos:prefLabel	"hydroxycinnamate 4-beta-glucosyltransferase"
RHEA:21636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxycinnamate 4-beta-glucosyltransferase"
REACT:R-BTA-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Bos taurus)
RHEA:71473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6) => H2O + substance P
REACT:R-RNO-9619355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the cytosol (Rattus norvegicus)
RHEA:12426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + oxaloacetate => (3S)-3-hydroxy-L-aspartate
RHEA:26088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)
RHEA:63519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2',3-triol + H(+) + NADH + O2 <=> biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)
GO:0001039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase III hybrid type promoter DNA binding
GO:0001039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III hybrid type promoter sequence-specific DNA binding
GO:0050267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rubber allyltransferase activity
GO:0050267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rubber prenyltransferase activity
GO:0050267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-prenyl transferase activity
GO:0050267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rubber cis-polyprenylcistransferase activity
GO:0050267	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	rubber transferase activity
GO:0050267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity
GO:0050267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity
GO:0050267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rubber polymerase activity
REACT:R-SSC-139842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Syk tyrosine kinase (Sus scrofa)
RHEA:21619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)
REACT:R-RNO-416546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Rattus norvegicus)
REACT:R-DME-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Drosophila melanogaster)
REACT:R-SSC-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Sus scrofa)
REACT:R-CEL-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Caenorhabditis elegans)
REACT:R-HSA-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)
REACT:R-RNO-9710106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE cleaves GSDMD (Rattus norvegicus)
REACT:R-DDI-376364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp8 associated secretory vesicle to plasma membrane transport (Dictyostelium discoideum)
REACT:R-XTR-5638333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)
REACT:R-HSA-9712190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol (Homo sapiens)
REACT:R-BTA-444838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 1 binds relaxin 2 and 3 (Bos taurus)
REACT:R-XTR-2002428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen N-propeptides (Xenopus tropicalis)
REACT:R-CFA-158781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Canis familiaris)
RHEA:55175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + hexanoyl-CoA + O2 <=> 2-hydroxyhexanoyl-CoA + CO2 + succinate
REACT:R-HSA-381612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1 (Homo sapiens)
REACT:R-GGA-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Gallus gallus)
REACT:R-CFA-192335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Canis familiaris)
REACT:R-SSC-264678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Sus scrofa)
RHEA:51834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out)
REACT:R-SSC-2032396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3 migrates to the nucleus (Sus scrofa)
GO:0008195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid phosphatidyl phosphatase activity
GO:0008195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-sn-phosphatidate phosphohydrolase activity
GO:0008195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidate phosphatase activity
GO:0008195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidic acid phosphatase activity
GO:0008195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatic acid phosphatase activity
GO:0008195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidate phosphohydrolase activity
GO:0008195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatic acid phosphohydrolase activity
REACT:R-MMU-420739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPRC6A can bind L-alpha amino acids and calcium (Mus musculus)
REACT:R-CEL-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Caenorhabditis elegans)
REACT:R-CFA-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Canis familiaris)
REACT:R-SSC-5654677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR2 (Sus scrofa)
REACT:R-RNO-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Rattus norvegicus)
RHEA:52141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O => a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)
RHEA:28428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-fructose 6-phosphate => D-allulose 6-phosphate
REACT:R-HSA-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
REACT:R-DME-1181153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Drosophila melanogaster)
RHEA:25871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1),N(12)-diacetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine
REACT:R-SSC-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Sus scrofa)
REACT:R-HSA-6799202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
REACT:R-MMU-191763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP:Snurportin complex formation (Mus musculus)
REACT:R-HSA-9006992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 is phosphorylated at S423 (Homo sapiens)
RHEA:21714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + glycine => L-threo-3-phenylserine
REACT:R-HSA-8948231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)
REACT:R-XTR-9024766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Xenopus tropicalis)
RHEA:22855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + pyruvate <=> 3-hydroxypyruvate + L-alanine
RHEA:15855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + H(+) + NADH => (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+)
REACT:R-DRE-2022052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Danio rerio)
REACT:R-DME-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
RHEA:34157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
GO:0070506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDL receptor
GO:0070506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-density lipoprotein receptor activity
GO:0070506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-density lipoprotein particle receptor activity
RHEA:62837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine
REACT:R-DME-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
REACT:R-CFA-354073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PTK2 at Y397 (Canis familiaris)
REACT:R-BTA-212706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipase C-gamma1 binds to the activated EGF receptor (Bos taurus)
REACT:R-RNO-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Rattus norvegicus)
REACT:R-SPO-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Schizosaccharomyces pombe)
RHEA:18822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + choline => acetylcholine + CoA
REACT:R-DME-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Drosophila melanogaster)
RHEA:39850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + ATP <=> a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)
REACT:R-CEL-8866269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB bind GPCRs (Caenorhabditis elegans)
REACT:R-DDI-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Dictyostelium discoideum)
REACT:R-DRE-5250210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Danio rerio)
REACT:R-BTA-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Bos taurus)
REACT:R-MMU-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Mus musculus)
RHEA:42489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III => 3'-N-debenzoyl-2'-deoxytaxol + CoA
RHEA:44706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-CFA-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Canis familiaris)
REACT:R-CEL-354073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
RHEA:38455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
GO:0080043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-O-glucosyltransferase activity
REACT:R-HSA-8987015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20 binds IL20RA:JAK1:IL20RB (Homo sapiens)
RHEA:57782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-4-methylcatechol + NAD(+) + nitrite => 2-chloro-4-nitrotoluene + NADH + O2
RHEA:48962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O => [thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide
GO:0034215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin:hydrogen symporter activity
GO:0034215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin:proton symporter activity
GO:0034215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine:hydrogen symporter activity
GO:0034215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine:proton symporter activity
RHEA:19420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + a dolichyl diphosphate <=> [phosphate](n+1) + a dolichyl phosphate
RHEA:68715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (1S,2S,4R)-beta-elemene + diphosphate
RHEA:50238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-212269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Sus scrofa)
REACT:R-GGA-372977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinylCoA + ADP + Pi <=> succinate + CoASH + ATP (Gallus gallus)
REACT:R-MMU-5696213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to methylarsonite (Mus musculus)
RHEA:49310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:0) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O
REACT:R-SSC-5666169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Sus scrofa)
REACT:R-CEL-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Caenorhabditis elegans)
RHEA:52610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + H(+) + NADPH => 2-hydroxybutanoate + NADP(+)
GO:0120298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide noradrenalinyltransferase activity
GO:0120298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)
RHEA:56874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-phenylethylamine + acetate => (S)-N-acetyl-1-phenylethylamine + H2O
RHEA:65485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + hexanoyl-CoA => CoA + hexyl hexanoate
GO:0034847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity
RHEA:48131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesyl phosphate + H(+) + phosphate
REACT:R-CFA-159005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)
REACT:R-DME-2029465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
RHEA:65324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + chrodrimanin A = chrodrimanin B + CoA
REACT:R-BTA-450551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 binds translation and heat shock proteins (Bos taurus)
RHEA:39681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA => (11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA
REACT:R-CEL-8949659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Caenorhabditis elegans)
REACT:R-DME-936986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains (Drosophila melanogaster)
REACT:R-MMU-1461993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-HD5 is cleaved by trypsin (Mus musculus)
GO:0001163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase I regulatory region DNA binding
GO:0001163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase I transcription regulatory region sequence-specific DNA binding
REACT:R-SPO-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Schizosaccharomyces pombe)
REACT:R-CFA-1250264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP binds reduced thioredoxin (Canis familiaris)
RHEA:40170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + O2 <=> (2E)-hexadecenoyl-CoA + H2O2
REACT:R-GGA-448963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of MyoD:E protein with MEF2 (Gallus gallus)
REACT:R-CEL-400071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Caenorhabditis elegans)
GO:0102178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity
RHEA:53145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
RHEA:31893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenyl-1,2-propanedione + H(+) + NADPH => 2-hydroxy-1-phenyl-1-propanone + NADP(+)
REACT:R-GGA-9708536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 translocates from the cytosol to the nucleoplasm (Gallus gallus)
RHEA:12626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose => D-glucose + sinapoyl (S)-malate
REACT:R-CFA-112379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of elongation factors to form elongation complex (Canis familiaris)
REACT:R-RNO-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Rattus norvegicus)
REACT:R-RNO-6793685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated TP53 translocates to the cytosol (Rattus norvegicus)
REACT:R-SSC-9632034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GlcA to chondroitin (Sus scrofa)
REACT:R-XTR-158354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Xenopus tropicalis)
RHEA:16495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 1-phosphate + H(+) => glycerol 1,2-cyclic phosphate + H2O
REACT:R-HSA-9614662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,(FOXO4) bind FASLG gene promoter (Homo sapiens)
RHEA:58804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-pApG-3' + H2O = 5'-ApG-3' + phosphate
RHEA:43522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dicarboxyfuran + H(+) + H2O2 => 2-carboxy-5-(dihydroxymethyl)furan + O2
REACT:R-DDI-194678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
REACT:R-HSA-9621385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1 binds TRIB1 gene (Homo sapiens)
RHEA:56398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+) => [(3R)-hydroxybutanoate](n) + H2O
RHEA:70013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + anthraniloyl-CoA + H(+) => 2-aminobenzoyl-AMP + CoA
REACT:R-RNO-141439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of activated MAD2 from kinetochores (Rattus norvegicus)
REACT:R-MMU-2187355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters phosphorylated SMAD2/3 (Mus musculus)
RHEA:16067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + phytanoyl-CoA
REACT:R-RNO-706479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated (Rattus norvegicus)
RHEA:21465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + thiocyanate => carbonyl sulfide + NH4(+)
REACT:R-HSA-9700149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds PLCG1 (Homo sapiens)
REACT:R-XTR-6798258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTPRF, PTPRS, PTPRD bind LRRC4B (Xenopus tropicalis)
RHEA:11003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-carbamoyl-D-amino acid + 2 H(+) + H2O <=> a D-alpha-amino acid + CO2 + NH4(+)
REACT:R-CFA-8950537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Canis familiaris)
RHEA:67649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + H2O => 2'-deoxyadenosine + H(+) + triphosphate
REACT:R-RNO-158278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Rattus norvegicus)
RHEA:44082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + undecanoyl-CoA => ATP + CoA + undecanoate
REACT:R-XTR-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Xenopus tropicalis)
REACT:R-DME-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)
RHEA:30894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + thiosulfate <=> acetate + H(+) + S-sulfo-L-cysteine
REACT:R-MMU-8863914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of SEC22B, TAP and PLC from ER to ERGIC (Mus musculus)
REACT:R-XTR-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Xenopus tropicalis)
REACT:R-SSC-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Sus scrofa)
RHEA:51107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Sus scrofa)
REACT:R-DME-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Drosophila melanogaster)
REACT:R-BTA-1606839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Steryl sulfatase hydrolyses sulfate from steroid sulfates (Bos taurus)
REACT:R-RNO-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Rattus norvegicus)
REACT:R-BTA-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Bos taurus)
REACT:R-SSC-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Sus scrofa)
REACT:R-HSA-190268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)
RHEA:67283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione <=> (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione
RHEA:36578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sphinganine <=> CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine
REACT:R-MMU-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Mus musculus)
REACT:R-MMU-9688456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds FLOT1, FLOT2 (Mus musculus)
REACT:R-MMU-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Mus musculus)
REACT:R-BTA-8948775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKRN1 polyubiquitinates PTEN (Bos taurus)
REACT:R-DRE-9724745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds aprotinin (Danio rerio)
REACT:R-BTA-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
REACT:R-SPO-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Schizosaccharomyces pombe)
REACT:R-MMU-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Mus musculus)
REACT:R-HSA-2002401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Homo sapiens)
GO:0015400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	low affinity ammonium transmembrane transporter activity
GO:0015400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity secondary active ammonium transmembrane transporter activity
GO:0015400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity secondary active ammonium transmembrane transporter activity
REACT:R-CFA-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Canis familiaris)
REACT:R-MMU-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)
REACT:R-GGA-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Gallus gallus)
REACT:R-HSA-9031510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of APOC1 regulated by NR1H2 or NR1H3 (Homo sapiens)
REACT:R-HSA-9700181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of ALK fusions (Homo sapiens)
REACT:R-CEL-374681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 and NCAM1 engaged in cis-interaction (Caenorhabditis elegans)
RHEA:16823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-2-dehydro-D-gluconate + H(+) + NADH => 6-phospho-D-gluconate + NAD(+)
REACT:R-DRE-163741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Danio rerio)
RHEA:28648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetophenone + 2 ATP + H2O + hydrogencarbonate => 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate
REACT:R-BTA-5607740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta phosphorylates CARD9 (Bos taurus)
REACT:R-CFA-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Canis familiaris)
REACT:R-DME-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Drosophila melanogaster)
RHEA:11067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1,6-bisphosphate + H2O <=> beta-D-fructose 6-phosphate + phosphate
REACT:R-HSA-8937191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Homo sapiens)
GO:0043035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin insulator sequence binding
RHEA:30294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-MMU-110248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 3-methyladenine by MPG glycosylase  (Mus musculus)
GO:0031739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholecystokinin receptor binding
GO:0031739	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cholecystokinin receptor ligand
REACT:R-CEL-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Caenorhabditis elegans)
REACT:R-BTA-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Bos taurus)
REACT:R-MMU-391936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP1 receptor can bind PGE2 (Mus musculus)
GO:0047966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycosulfatase"
GO:0047966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosulphatase activity
GO:0047966	skos:prefLabel	"glycosulfatase"
GO:0047966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-sulfate + H2O = D-glucose + H(+) + sulfate
GO:0047966	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sugar-sulfate sulfohydrolase activity
GO:0047966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosulfatase activity
GO:0047966	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosulfatase activity
GO:0047966	skos:altLabel	"glucosulfatase"
REACT:R-CFA-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Canis familiaris)
RHEA:48721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin B + H2O + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH
RHEA:67533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine
REACT:R-CFA-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)
RHEA:38811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:19914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + NAD(+) => a 3-oxoacyl-[ACP] + H(+) + NADH
REACT:R-RNO-8964274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12) binds BTK (Rattus norvegicus)
RHEA:64736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH
REACT:R-DME-6814678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Drosophila melanogaster)
REACT:R-MMU-3215448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Mus musculus)
REACT:R-HSA-6786096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Homo sapiens)
REACT:R-HSA-140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor V -> factor Va + factor V activation peptide (Homo sapiens)
RHEA:71311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-alanine(out) + 2 Na(+)(out) = chloride(in) + L-alanine(in) + 2 Na(+)(in)
RHEA:68061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:25721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-trihomomethionine
RHEA:48654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Drosophila melanogaster)
REACT:R-BTA-727819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 phosphorylates MKK6 (Bos taurus)
REACT:R-SSC-5685607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sialic acid binds SIGLEC (Sus scrofa)
REACT:R-RNO-77271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Rattus norvegicus)
RHEA:41486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine
REACT:R-DDI-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Dictyostelium discoideum)
REACT:R-BTA-1237325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A is protonated and carbamated causing release of oxygen (Bos taurus)
REACT:R-MMU-201475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with R-Smad1/5/8 for type I receptor (Mus musculus)
RHEA:40363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)
REACT:R-MMU-6814409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates PDCL (Mus musculus)
RHEA:62227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + neopatulin <=> (E)-ascladiol + NADP(+)
REACT:R-HSA-6804942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 homodimers auto-ubiquitinate (Homo sapiens)
GO:0004494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmalonyl coenzyme A mutase activity
GO:0004494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmalonyl coenzyme A carbonylmutase activity
GO:0004494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmalonyl-CoA CoA-carbonyl mutase activity
GO:0004494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-methylmalonyl-CoA mutase activity
GO:0004494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-methylmalonyl-CoA CoA-carbonylmutase activity
GO:0004494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity
GO:0004494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl-CoA mutase activity
REACT:R-RNO-5653756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM25 binds monoUb:164-PCNA (Rattus norvegicus)
GO:0004459	skos:altLabel	"L-lactic acid dehydrogenase"
GO:0004459	skos:prefLabel	"L-lactate dehydrogenase"
GO:0004459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lactic dehydrogenase activity
GO:0004459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + NAD(+) = H(+) + NADH + pyruvate
GO:0004459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-lactate dehydrogenase"
GO:0004459	skos:altLabel	"L-lactic dehydrogenase"
GO:0004459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lactate dehydrogenase activity
GO:0004459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lactic acid dehydrogenase activity
REACT:R-XTR-8867240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPCAM binds itself to form homotypic cell adhesion (Xenopus tropicalis)
REACT:R-MMU-5423038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Mus musculus)
RHEA:20214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] => L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]
REACT:R-DRE-8936851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHRR binds ARNT (Danio rerio)
RHEA:34245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + Mo-molybdopterin guanine dinucleotide => GTP + H(+) + Mo-molybdopterin
RHEA:12518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(R)-germacrene A + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-BTA-8847638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Bos taurus)
REACT:R-MMU-8983374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Mus musculus)
REACT:R-BTA-201634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of FADK 1 (Bos taurus)
REACT:R-HSA-8940959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurolysin degrades neurotensin (Homo sapiens)
REACT:R-DRE-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Danio rerio)
REACT:R-SSC-3076905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular BTD hydrolyses BCTN (Sus scrofa)
REACT:R-RNO-8848776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates DOK1 (Rattus norvegicus)
REACT:R-CFA-5653754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Canis familiaris)
REACT:R-CFA-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Canis familiaris)
REACT:R-HSA-5682893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12:ATG7:CysO572-ATG7 binds ATG10 (Homo sapiens)
RHEA:28399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate
REACT:R-HSA-8987270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Homo sapiens)
REACT:R-CEL-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Caenorhabditis elegans)
REACT:R-DRE-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Danio rerio)
GO:0008499	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta3Gal-Ts activity
GO:0008499	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-1,3-GalTase activity
GO:0008499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
GO:0008499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity
GO:0008499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
REACT:R-CFA-9701531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727 STAT3 is acetylated (Canis familiaris)
REACT:R-DDI-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Dictyostelium discoideum)
REACT:R-DRE-3928627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB phosphorylates TIAM1 (Danio rerio)
REACT:R-HSA-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Homo sapiens)
REACT:R-DRE-2454240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-FCERI gamma subunit (Danio rerio)
REACT:R-MMU-975902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)
RHEA:61338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + protoporphyrin IX(out) => ATP + H2O + protoporphyrin IX(in)
RHEA:35954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate <=> diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
GO:0005175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD27 receptor binding
RHEA:14803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + ADP => (2R)-3-phosphoglycerate + ATP
RHEA:43511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diformylfuran + H2O <=> 2-(dihydroxymethyl)-5-formylfuran
REACT:R-HSA-379048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
REACT:R-CFA-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Canis familiaris)
REACT:R-RNO-5682965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Rattus norvegicus)
REACT:R-HSA-9664270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLCgamma to membrane due to FCGR3A effect (Homo sapiens)
REACT:R-MMU-1793186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Mus musculus)
RHEA:22572	skos:prefLabel	"methylglutamate dehydrogenase"
RHEA:22572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylglutamate dehydrogenase"
RHEA:22572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N-methyl-L-glutamate = AH2 + formaldehyde + L-glutamate
REACT:R-CEL-2731074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Caenorhabditis elegans)
REACT:R-MMU-9667952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 is deacetylated by SIRT2 (Mus musculus)
REACT:R-RNO-917811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3-like proteins reduce Fe3+ to Fe2+ (Rattus norvegicus)
RHEA:59562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N',N''-triacetylchitotrionate => H2O + N,N',N''-triacetylchitotriono-1,5-lactone
REACT:R-RNO-844438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 oligomerizes (Rattus norvegicus)
REACT:R-XTR-3465545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Xenopus tropicalis)
REACT:R-CFA-182594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of INK4 family proteins with CDK4/6 (Canis familiaris)
REACT:R-PFA-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)
REACT:R-DME-74746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y427-SHC1 (Drosophila melanogaster)
REACT:R-XTR-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Xenopus tropicalis)
REACT:R-BTA-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Bos taurus)
REACT:R-BTA-141200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates of PEA (Bos taurus)
GO:0043817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)
GO:0043817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-O-phospho-3-sulfolactate sulfo-lyase activity
GO:0043817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphosulfolactate synthase activity
GO:0043817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PSL synthase activity
GO:0043817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R)-phospho-3-sulfolactate synthase activity
REACT:R-BTA-8985591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2-bound ROBO1 binds MYO9B (Bos taurus)
RHEA:67654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + diphosphate => dADP + H2O
REACT:R-XTR-6782004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the pre-incision complex in TC-NER (Xenopus tropicalis)
RHEA:10773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O => D-glucose + D-glucose 6-phosphate
REACT:R-DME-8936608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)
EC:3.2.1.21	skos:prefLabel	"beta-glucosidase"
EC:3.2.1.21	skos:altLabel	"cellobiase"
EC:3.2.1.21	skos:altLabel	"beta-D-glucoside glucohydrolase"
EC:3.2.1.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-glucosidase"
EC:3.2.1.21	skos:altLabel	"amygdalase"
EC:3.2.1.21	skos:altLabel	"gentobiase"
RHEA:61546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0030557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA modification guide activity
RHEA:19396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + pyruvate <=> (S)-2-amino-6-oxohexanoate + L-alanine
RHEA:59683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaose + O2 <=> D-maltopentaono-1,5-lactone + H2O2
REACT:R-HSA-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Homo sapiens)
REACT:R-SSC-9716258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimethyl fumarate modifies Cys191 in GSDMD (Sus scrofa)
REACT:R-SSC-5649725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Sus scrofa)
REACT:R-GGA-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Gallus gallus)
REACT:R-RNO-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Rattus norvegicus)
RHEA:59813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]
RHEA:18125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 + NH4(+)
EC:3.4.24.14	skos:altLabel	"procollagen N-proteinase"
EC:3.4.24.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"procollagen N-endopeptidase"
EC:3.4.24.14	skos:prefLabel	"procollagen N-endopeptidase"
RHEA:55666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + canthaxanthin + 3 H2O => 2 AH2 + echinenone + 2 O2
REACT:R-DDI-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Dictyostelium discoideum)
REACT:R-CEL-193743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
REACT:R-DRE-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Danio rerio)
REACT:R-RNO-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Rattus norvegicus)
REACT:R-BTA-8871227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA4 (Bos taurus)
REACT:R-XTR-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Xenopus tropicalis)
RHEA:58004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside F2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP
REACT:R-DRE-158251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Danio rerio)
RHEA:56922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty acyl-AMP + diphosphate => a medium chain fatty acid + ATP + H(+)
RHEA:62397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-pseudoephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
RHEA:19708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanal + NAD(+) <=> H(+) + hexadecanoyl-CoA + NADH
GO:0033717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-gluconate dehydrogenase activity
GO:0033717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-gluconate:acceptor 2-oxidoreductase activity
GO:0033717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gluconate 2-dehydrogenase (acceptor) activity
GO:0033717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity
GO:0033717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gluconate oxidase activity
GO:0033717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gluconic acid dehydrogenase activity
GO:0033717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-gluconate:(acceptor) 2-oxidoreductase activity
GO:0033717	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-ketogluconate reductase activity
GO:0033717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gluconic dehydrogenase activity
RHEA:48723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin B + H2O + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH
REACT:R-SCE-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Saccharomyces cerevisiae)
REACT:R-RNO-2025723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the N-glycan precursor (Rattus norvegicus)
REACT:R-SPO-199839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate RSK (Schizosaccharomyces pombe)
GO:0043754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrolipoamide branched chain acyltransferase activity
GO:0043754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoyl transacylase activity
GO:0043754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity
GO:0043754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity
GO:0043754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity
GO:0043754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrolipoamide branched chain transacylase activity
GO:0043754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity
RHEA:41488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine
REACT:R-RNO-8956031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Rattus norvegicus)
RHEA:44762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine
REACT:R-SSC-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Sus scrofa)
REACT:R-SSC-202394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CARMA1 to Plasma membrane (Sus scrofa)
RHEA:47000	skos:prefLabel	"NAD(P)(+) transhydrogenase (ferredoxin)"
RHEA:47000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:47000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(P)(+) transhydrogenase (ferredoxin)"
REACT:R-BTA-444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR5 binds CXCL13 (Bos taurus)
RHEA:52455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-HSA-8959719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPK phosphorylates Sedo to Sedo7P (Homo sapiens)
REACT:R-GGA-9686980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 recruits APC/C:Cdh1 complex to SKP2 (Gallus gallus)
REACT:R-DRE-2465938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates atROL taken up by Muller cells (Danio rerio)
RHEA:66923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate <=> (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate
RHEA:37103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)
GO:0031849	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	olfactory receptor ligand
GO:0031849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	olfactory receptor binding
REACT:R-CFA-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Canis familiaris)
RHEA:33761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-hydroxy-fatty acyl-CoA + NADP(+) => a 3-oxo-fatty acyl-CoA + H(+) + NADPH
RHEA:18077	skos:prefLabel	"NAD(+)--dinitrogen-reductase ADP-D-ribosyltransferase"
RHEA:18077	skos:altLabel	"NAD-azoferredoxin (ADPribose)transferase"
RHEA:18077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[dinitrogen reductase] + NAD(+) = H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide
RHEA:18077	skos:altLabel	"NAD-dinitrogen-reductase ADP-D-ribosyltransferase"
RHEA:18077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(+)--dinitrogen-reductase ADP-D-ribosyltransferase"
REACT:R-SSC-373748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD72 (Sus scrofa)
REACT:R-RNO-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Rattus norvegicus)
REACT:R-GGA-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Gallus gallus)
RHEA:50319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl octadecanoate + H2O <=> ethanol + H(+) + octadecanoate
RHEA:28068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli)
REACT:R-XTR-1028820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of VAF (virus-activated factor) complex (Xenopus tropicalis)
RHEA:55001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-GGA-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Gallus gallus)
EC:1.3.1.3	skos:altLabel	"Delta(4)-3-ketosteroid 5beta-reductase"
EC:1.3.1.3	skos:altLabel	"Delta(4)-5beta-reductase"
EC:1.3.1.3	skos:altLabel	"cortisone Delta(4)-5beta-reductase"
EC:1.3.1.3	skos:altLabel	"Delta(4)-hydrogenase"
EC:1.3.1.3	skos:altLabel	"cholestenone 5beta-reductase"
EC:1.3.1.3	skos:altLabel	"5beta-reductase"
EC:1.3.1.3	skos:altLabel	"steroid 5beta-reductase"
EC:1.3.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Delta(4)-3-oxosteroid 5beta-reductase"
EC:1.3.1.3	skos:altLabel	"3-oxo-Delta(4)-steroid 5beta-reductase"
EC:1.3.1.3	skos:altLabel	"androstenedione 5beta-reductase"
EC:1.3.1.3	skos:altLabel	"cortisone beta-reductase"
EC:1.3.1.3	skos:prefLabel	"Delta(4)-3-oxosteroid 5beta-reductase"
EC:1.3.1.3	skos:altLabel	"testosterone 5beta-reductase"
EC:1.3.1.3	skos:altLabel	"cortisone 5beta-reductase"
REACT:R-CFA-204871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb2 (Canis familiaris)
RHEA:44315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoylglycerol + H2O <=> glycerol + H(+) + tetradecanoate
RHEA:22785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-O-phospho-3-sulfolactate => H(+) + phosphoenolpyruvate + sulfite
GO:0031775	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lutropin-choriogonadotropic hormone receptor ligand
GO:0031775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutropin-choriogonadotropic hormone receptor binding
RHEA:68705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) => 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Canis familiaris)
REACT:R-XTR-6795460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK1 phosphorylates MDM2 (Xenopus tropicalis)
REACT:R-MMU-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Mus musculus)
RHEA:53579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-199112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRTAM binds to NECL2 (Xenopus tropicalis)
RHEA:58352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate
REACT:R-HSA-1225952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
REACT:R-BTA-205328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other tyrosine kinases with p-KIT (Bos taurus)
REACT:R-HSA-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Homo sapiens)
REACT:R-SSC-8987223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10RB binds TYK2 (Sus scrofa)
RHEA:44722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + H(+) + phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O
REACT:R-DME-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Drosophila melanogaster)
REACT:R-RNO-9012761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI binds RHOA-GDI (Rattus norvegicus)
GO:0033735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP+-dependent aspartate dehydrogenase activity
GO:0033735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2-dependent aspartate dehydrogenase activity
GO:0033735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity
GO:0033735	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartate dehydrogenase NADP activity
GO:0033735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate dehydrogenase activity
GO:0033735	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartate dehydrogenase NAD activity
GO:0033735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent aspartate dehydrogenase activity
RHEA:25743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-pentahomomethionine = (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O
REACT:R-DME-209061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)
GO:0033718	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinone-dependent pyranose dehydrogenase activity
GO:0033718	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyranose dehydrogenase activity
GO:0033718	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyranose:acceptor oxidoreductase activity
GO:0033718	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDH
GO:0033718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyranose dehydrogenase (acceptor) activity
GO:0033718	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyranose-quinone oxidoreductase activity
REACT:R-DRE-420131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PACAP receptor binds PACAP (Danio rerio)
GO:0031804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 7 metabotropic glutamate receptor binding
GO:0031804	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 7 metabotropic glutamate receptor ligand
RHEA:50494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein]
GO:0050633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity
GO:0050633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxopalmitoyl-CoA hydrolase activity
GO:0050633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA C-myristoyltransferase activity
GO:0050633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxopalmitoyl-CoA-CoA acetyltransferase activity
GO:0050633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myristoyl-CoA C-acetyltransferase activity
REACT:R-SSC-2130478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of invariant chain trimer and MHC II alpha beta dimer (Sus scrofa)
REACT:R-CEL-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Caenorhabditis elegans)
RHEA:31258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate
RHEA:15539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfopyruvate + H(+) + NADPH => (2R)-3-sulfolactate + NADP(+)
REACT:R-HSA-8948230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P3HB binds 4-Hyp-collagen propeptides (Homo sapiens)
REACT:R-CFA-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)
REACT:R-CFA-8851044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN1A1 binds xanthine oxidoreductase (XDH) (Canis familiaris)
REACT:R-DRE-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Danio rerio)
REACT:R-DME-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Drosophila melanogaster)
REACT:R-RNO-6801195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3 binds BNIP3L (Rattus norvegicus)
RHEA:25829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 => A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O
REACT:R-CFA-5682586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 and PIAS4 are recruited to DNA DSBs (Canis familiaris)
REACT:R-HSA-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Homo sapiens)
RHEA:50609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + NADP(+) => 12-oxo-leukotriene B4 + H(+) + NADPH
GO:0061609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose-1-phosphate aldolase activity
REACT:R-CFA-5690790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H2A is dubiquitinated by the PR-DUB complex (Canis familiaris)
RHEA:35562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinone-7 + NADH <=> menaquinol-7 + NAD(+)
REACT:R-MMU-399978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase C, alpha type phosphorylates MARCKS (Mus musculus)
REACT:R-CFA-5159250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF7IP binds SETDB1 (Canis familiaris)
RHEA:71678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-leucine(out) + H(+)(out) <=> glycyl-L-leucine(in) + H(+)(in)
REACT:R-CEL-8941543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:30282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:44503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)
RHEA:40579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-CFA-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Canis familiaris)
RHEA:62841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-BTA-389491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two NPFF receptors can bind neuropeptide FF (Bos taurus)
RHEA:34445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose
REACT:R-HSA-2028598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS1 (Homo sapiens)
EC:3.6.4.13	skos:prefLabel	"RNA helicase"
EC:3.6.4.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RNA helicase"
REACT:R-DME-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Drosophila melanogaster)
REACT:R-MMU-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Mus musculus)
REACT:R-GGA-5676940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Gallus gallus)
RHEA:15615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + sirohydrochlorin => NAD(+) + precorrin-2
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol 3beta-glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol:UDPG glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:sterol glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDPG:sterol glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-sterol glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-sterol glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol 3-beta-glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol-beta-D-glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-sterol beta-glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-poriferasterol glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity
GO:0016906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG-SGTase activity
REACT:R-RNO-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)
REACT:R-HSA-9648983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Homo sapiens)
GO:0015643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toxic substance binding
GO:0015643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	antitoxin activity
GO:0015643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoprotein antitoxin
GO:0047144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity
GO:0047144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-acylglycerophosphate acyltransferase activity
GO:0047144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acylglycerol-3-phosphate O-acyltransferase activity
REACT:R-MMU-9734070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET recombinant therapeutic antibodies bind MET (Mus musculus)
REACT:R-RNO-5252041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Rattus norvegicus)
RHEA:43316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DME-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
REACT:R-BTA-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Bos taurus)
REACT:R-DME-199863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate NR4A1 (NUR77) (Drosophila melanogaster)
REACT:R-SSC-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Sus scrofa)
REACT:R-DDI-2142859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growing HA is extruded from the cell by ABCC5 (Dictyostelium discoideum)
RHEA:71393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) => 16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out)
RHEA:17682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpropanoate + NAD(+) => 2-methyl-3-oxopropanoate + H(+) + NADH
REACT:R-BTA-349444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of COP1 at Ser-387  by ATM (Bos taurus)
REACT:R-GGA-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Gallus gallus)
RHEA:29782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-methionine(out) <=> ADP + H(+) + L-methionine(in) + phosphate
REACT:R-MMU-1433542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV1 (Mus musculus)
REACT:R-MMU-111237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR1 homodimer (Mus musculus)
RHEA:34201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bracteatin 6-O-beta-glucoside + H2O => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2
REACT:R-HSA-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Homo sapiens)
RHEA:62310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)
RHEA:62243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine(6-4)cytidine in DNA <=> a thymine-cytidine dinucleotide in DNA
REACT:R-RNO-1461982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-defensin dimers multimerize to form a pore complex (Rattus norvegicus)
GO:0004972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMDA receptor
GO:0004972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMDA glutamate receptor activity
GO:0004972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-D-aspartate selective glutamate receptor activity
RHEA:60009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA precursor + 2 CTP => a tRNA with a 3' CC end + 2 diphosphate
REACT:R-GGA-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Gallus gallus)
REACT:R-SSC-6810410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Sus scrofa)
RHEA:42206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-dehydrocorticosterone + H(+) + NADH => corticosterone + NAD(+)
RHEA:42754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine
RHEA:11899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol + NAD(+) <=> 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH
RHEA:44416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)
REACT:R-DRE-9027627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Danio rerio)
REACT:R-GGA-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Gallus gallus)
REACT:R-MMU-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Mus musculus)
RHEA:68077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP => a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP
REACT:R-DDI-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Dictyostelium discoideum)
REACT:R-CFA-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Canis familiaris)
REACT:R-HSA-877178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds to P2X7 (Homo sapiens)
REACT:R-CEL-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Caenorhabditis elegans)
REACT:R-BTA-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Bos taurus)
REACT:R-HSA-1562641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)
REACT:R-SSC-8850992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated PTEN (Sus scrofa)
REACT:R-XTR-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)
REACT:R-BTA-5654426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
GO:0031797	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 metabotropic GABA receptor ligand
GO:0031797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 metabotropic GABA receptor binding
GO:0051427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hormone receptor binding
REACT:R-MMU-1482545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)
RHEA:71288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-arginine(out) + 2 Na(+)(out) => chloride(in) + L-arginine(in) + 2 Na(+)(in)
GO:0033439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine tRNA
GO:0033439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACA codon-amino acid adaptor activity
REACT:R-MMU-420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretin receptor binds secretin (Mus musculus)
REACT:R-RNO-8852324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds PLK1 (Rattus norvegicus)
REACT:R-DME-451839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCO binds to FT (Drosophila melanogaster)
REACT:R-MMU-451347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JNK by DSCAM (Mus musculus)
RHEA:18910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trichlorophenol + S-adenosyl-L-methionine => 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine
REACT:R-BTA-2984226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NEK9 (Bos taurus)
REACT:R-HSA-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)
REACT:R-RNO-1912357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH ubiquitinates DTX (Rattus norvegicus)
REACT:R-BTA-400037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi,Go Heterotrimeric G-protein complex dissociates (Bos taurus)
RHEA:65986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lumisterol 3 => hnu + previtamin D3
REACT:R-HSA-9664588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
REACT:R-DME-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Drosophila melanogaster)
REACT:R-HSA-8938913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF1 (Homo sapiens)
RHEA:65048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetoxybenzyl alcohol + NAD(+) = 4-acetoxybenzaldehyde + H(+) + NADH
RHEA:41712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
RHEA:71084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + 2 Na(+)(out) => estrone 3-sulfate(in) + 2 Na(+)(in)
RHEA:22741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-hexose => ADP + D-hexose 6-phosphate + H(+)
REACT:R-CFA-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Canis familiaris)
RHEA:59308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactono-1,5-lactone + H2O = D-galactonate + H(+)
REACT:R-DDI-6783177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates GATA3,IL33 (Dictyostelium discoideum)
GO:0140395	skos:altLabel	"AVN hydroxylase"
GO:0140395	skos:prefLabel	"averantin hydroxylase"
GO:0140395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	averantin hydroxylase activity
GO:0140395	skos:altLabel	"CYP60A1"
GO:0140395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"averantin hydroxylase"
REACT:R-HSA-167134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly formed phosphodiester bond stabilized and PPi released (Homo sapiens)
REACT:R-GGA-193700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR ICD signals to NF-kB (Gallus gallus)
RHEA:10326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxycarbonyl + H(+) + NADPH => an L-glycol + NADP(+)
RHEA:33371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--trehalose phosphotransferase"
RHEA:33371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]
RHEA:33371	skos:prefLabel	"protein-N(pi)-phosphohistidine--trehalose phosphotransferase"
RHEA:33371	skos:altLabel	"trehalose PTS permease"
REACT:R-XTR-2160874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses (HA)50 (Xenopus tropicalis)
REACT:R-MMU-1237059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ dehydrates HCO3- to CO2 (Mus musculus)
REACT:R-MMU-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
RHEA:15175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + NADP(+) => H(+) + H2O2 + NADPH
REACT:R-HSA-6801166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the STEAP3 gene (Homo sapiens)
RHEA:46201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-8877902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated AR binds RUNX2 (Sus scrofa)
REACT:R-HSA-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Homo sapiens)
REACT:R-HSA-3325540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective extracellular BTD does not hydrolyse BCTN (Homo sapiens)
RHEA:38829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine
REACT:R-BTA-9026894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK2 (Bos taurus)
RHEA:33420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate
GO:0018706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity
GO:0018706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transhydroxylase activity
GO:0018706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrogallol hydroxytransferase activity
GO:0018706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity
GO:0018706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity
GO:0018706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrogallol hydroxyltransferase activity
GO:0018706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity
GO:0018706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)
REACT:R-SCE-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Saccharomyces cerevisiae)
RHEA:35195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-quinate(in) = L-quinate(out)
RHEA:33348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminoacetate + H2O => glyoxylate + NH4(+)
REACT:R-XTR-73739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Xenopus tropicalis)
REACT:R-RNO-195418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-2 associates with VEGFR1 forming complexes on  cell surface (Rattus norvegicus)
RHEA:38902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)
RHEA:71748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + L-2-aminoadipate(in) => 2-oxoglutarate(in) + L-2-aminoadipate(out)
REACT:R-DRE-6784319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)
RHEA:43002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O
REACT:R-RNO-5625849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM1A binds KLK2 and KLK3 promoters (Rattus norvegicus)
GO:0001055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II activity
GO:0001055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter
REACT:R-DME-390438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR2 reduces PalmCoA to HXOL (Drosophila melanogaster)
REACT:R-DRE-5685838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex binds D-loop structures (Danio rerio)
REACT:R-SSC-5690042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)
REACT:R-GGA-5333671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCAs self cleave (Gallus gallus)
RHEA:65631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine
RHEA:42709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(46) in tRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine
REACT:R-CFA-5250217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP binds ARL2BP (Canis familiaris)
REACT:R-HSA-6802930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance (Homo sapiens)
RHEA:31355	skos:prefLabel	"dissimilatory dimethyl-sulfide monooxygenase"
RHEA:31355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + H(+) + NADH + O2 = formaldehyde + H2O + methanethiol + NAD(+)
RHEA:31355	skos:altLabel	"dimethyl sulfide monooxygenase"
RHEA:31355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dissimilatory dimethyl-sulfide monooxygenase"
RHEA:31355	skos:altLabel	"dimethylsulfide monooxygenase"
RHEA:31355	skos:altLabel	"dimethyl sulfide C-monooxygenase"
REACT:R-HSA-375161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 trans-homophilic interaction (Homo sapiens)
REACT:R-RNO-437139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT6 transports zinc into the golgi apparatus (Rattus norvegicus)
RHEA:53910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-butenoyl-CoA + L-lysyl-[protein]
REACT:R-DRE-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Danio rerio)
RHEA:65737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + octyl sulfate => CO2 + H(+) + octanal + succinate + sulfate
REACT:R-RNO-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Rattus norvegicus)
GO:0004549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-specific RNase activity
GO:0004549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-specific ribonuclease activity
RHEA:12605	skos:altLabel	"1-deoxyxylulose-5-phosphate synthase"
RHEA:12605	skos:altLabel	"DXP-synthase"
RHEA:12605	skos:prefLabel	"1-deoxy-D-xylulose-5-phosphate synthase"
RHEA:12605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2
RHEA:12605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-deoxy-D-xylulose-5-phosphate synthase"
RHEA:12605	skos:altLabel	"1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating)"
REACT:R-HSA-2046096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Homo sapiens)
RHEA:68937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + nonanoate => AMP + diphosphate + NADP(+) + nonanal
REACT:R-CFA-6804741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 forms homo- or heterodimers (Canis familiaris)
REACT:R-CFA-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)
RHEA:13953	skos:altLabel	"D-tyrosyl-tRNA(Tyr) aminoacylhydrolase"
RHEA:13953	skos:altLabel	"D-Tyr-tRNA(Tyr) deacylase"
RHEA:13953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)
RHEA:13953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-aminoacyl-tRNA deacylase"
RHEA:13953	skos:prefLabel	"D-aminoacyl-tRNA deacylase"
REACT:R-CFA-1638104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Canis familiaris)
RHEA:29207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol(in) + dimethyl sulfoxide(out) = a menaquinone(in) + dimethyl sulfide(out) + H2O(out)
REACT:R-MMU-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Mus musculus)
REACT:R-BTA-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)
RHEA:65203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(acetaldehyde)-L-cysteine <=> (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetohydroxy acid reductoisomerase activity
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-keto-beta-hydroxylacyl reductoisomerase activity
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyisovalerate (isomerizing) dehydrogenase activity
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isomeroreductase activity
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ketol-acid reductoisomerase activity
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyisovalerate dehydrogenase (isomerizing) activity
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductoisomerase activity
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetolactate reductoisomerase activity
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetohydroxy acid isomeroreductase activity
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketol acid reductoisomerase activity
GO:0004455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-3-keto acid reductoisomerase activity
GO:0106313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydrofolate reductase NADPH activity
GO:0106313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH
REACT:R-MMU-6814374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kazrin binds periplakin (Mus musculus)
RHEA:15640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alginate](n) + GDP-alpha-D-mannuronate <=> [alginate](n+1) + GDP + H(+)
REACT:R-RNO-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Rattus norvegicus)
RHEA:44743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-O-demethylrifamycin SV + S-adenosyl-L-methionine <=> H(+) + rifamycin SV + S-adenosyl-L-homocysteine
REACT:R-SCE-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)
REACT:R-BTA-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Bos taurus)
RHEA:14356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate 6-phosphate + H(+) <=> CO2 + L-xylulose 5-phosphate
REACT:R-DRE-8848316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36 binds IL1RL2 (Danio rerio)
REACT:R-CFA-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)
RHEA:67366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + L-threonine => H2O + L-threonyl-L-serine
RHEA:58980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citral + H2O + O2 = 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2
RHEA:28822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate(in) + H(+)(in) <=> 5-dehydro-D-gluconate(out) + H(+)(out)
RHEA:72483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in)
GO:0015294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:cation symporter activity
REACT:R-HSA-5218827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
REACT:R-CFA-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Canis familiaris)
REACT:R-HSA-6785361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of FANCD2:FANCI (Homo sapiens)
REACT:R-XTR-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Xenopus tropicalis)
RHEA:21396	skos:altLabel	"methylmalonyl-coenzyme A decarboxylase"
RHEA:21396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)"
RHEA:21396	skos:altLabel	"(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase"
RHEA:21396	skos:prefLabel	"(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)"
RHEA:21396	skos:altLabel	"(S)-methylmalonyl-CoA carboxy-lyase"
RHEA:21396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) = CO2 + Na(+)(out) + propanoyl-CoA
REACT:R-HSA-2473584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP15 (Homo sapiens)
REACT:R-HSA-9646685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggresome dissociates from dynein and microtubule (Homo sapiens)
RHEA:11476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 1-phosphate + H2O = glycerol + phosphate
RHEA:57897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate
REACT:R-CFA-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Canis familiaris)
RHEA:63421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + CTP => cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate
REACT:R-HSA-8854738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR binds CSFR (Homo sapiens)
REACT:R-SSC-109759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Sus scrofa)
REACT:R-DRE-936564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 inhibits MAVS-DDX58 interaction. (Danio rerio)
GO:1990400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial LSU rRNA binding
GO:1990400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial ribosomal large subunit rRNA binding
GO:1990400	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	21S rRNA binding
REACT:R-BTA-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Bos taurus)
REACT:R-DRE-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Danio rerio)
REACT:R-RNO-2395992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,4S-IRF3 is dimerized (Rattus norvegicus)
RHEA:35103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fusidate(in) = fusidate(out)
REACT:R-BTA-1638053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from keratan sulfate (Bos taurus)
REACT:R-HSA-9031981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-phosphorylated FRS2 binds PTPN11 (Homo sapiens)
REACT:R-HSA-8877369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and FOXP3 bind the IFNG gene (Homo sapiens)
REACT:R-BTA-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Bos taurus)
REACT:R-HSA-205319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of APS and p-KIT (Homo sapiens)
REACT:R-SSC-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Sus scrofa)
REACT:R-SCE-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)
REACT:R-SSC-74247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Sus scrofa)
REACT:R-BTA-976991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor ligands bind the prolactin receptor (Bos taurus)
REACT:R-XTR-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Xenopus tropicalis)
REACT:R-SSC-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Sus scrofa)
REACT:R-HSA-9606894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DAPP1 (p-BAM32) binds PLCG2 (Homo sapiens)
RHEA:63760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine
REACT:R-MMU-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Mus musculus)
RHEA:15072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-devinyl-3-(1-hydroxyethyl)chlorophyllide a <=> chlorophyllide a + H2O
REACT:R-CFA-265427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Canis familiaris)
RHEA:30671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiose = 2 N-acetyl-D-glucosamine
RHEA:36274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + theobromine
GO:0033935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligoxyloglucan xyloglucohydrolase activity
GO:0033935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligoxyloglucan hydrolase activity
GO:0033935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoprimeverose-producing oligoxyloglucan hydrolase activity
GO:0033935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligoxyloglucan beta-glycosidase activity
GO:0003674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular function
GO:0003674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular_function
REACT:R-CFA-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Canis familiaris)
RHEA:68507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> (Z)-beta-farnesene + diphosphate
REACT:R-RNO-3214912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate MeK5-histone H3 (Rattus norvegicus)
REACT:R-HSA-8863472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAB2 binds LRP2 (Homo sapiens)
GO:0033749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-methyl-arginine-3 demethylase activity
GO:0033749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R3me demethylase activity
GO:0033749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-R3 demethylase activity
GO:0033749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R3 demethylase activity
GO:0033749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity (H4-R3 specific)
REACT:R-DME-3209159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERF translocates to the cytosol (Drosophila melanogaster)
RHEA:46357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] => 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-389972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (Homo sapiens)
REACT:R-MMU-9624778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD 12mer translocates from ER membrane to extracellular region (Mus musculus)
RHEA:14640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a thiol <=> adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate
RHEA:54604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + decanoyl-CoA + O2 = 2-hydroxydecanoyl-CoA + CO2 + succinate
RHEA:61477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + octadecanoyl-CoA => an N-octadecanoyl-sphingoid base + CoA + H(+)
RHEA:53672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O
RHEA:49442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate => (R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA
RHEA:24944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADPH
REACT:R-MMU-77283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Mus musculus)
REACT:R-RNO-947535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Rattus norvegicus)
RHEA:70015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + teasterone = 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:19197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylylsulfate--ammonia adenylyltransferase"
RHEA:19197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate
RHEA:19197	skos:prefLabel	"adenylylsulfate--ammonia adenylyltransferase"
REACT:R-HSA-1222662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric oxide enters the bacterium (Homo sapiens)
GO:0008734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate oxidase activity
GO:0008734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate:oxygen oxidoreductase
REACT:R-GGA-389424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The orphan QRFP receptor can bind neuropeptide QRFP (Gallus gallus)
RHEA:35959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tryprostatin B = demethoxyfumitremorgin C + 2 H2O + NADP(+)
RHEA:72461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(out) + L-aspartate(in) => fumarate(in) + L-aspartate(out)
REACT:R-SPO-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Schizosaccharomyces pombe)
RHEA:17188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + NADP(+) + NH4(+) <=> GMP + 2 H(+) + NADPH
RHEA:19084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-haloalkane + H2O <=> a halide anion + a primary alcohol + H(+)
RHEA:53597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-sn-glycerol + phosphate
REACT:R-XTR-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Xenopus tropicalis)
RHEA:17261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arylsulfatase (type I)"
RHEA:17261	skos:altLabel	"aryl-sulfate sulphohydrolase"
RHEA:17261	skos:altLabel	"sulfatase"
RHEA:17261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aryl sulfate + H2O = a phenol + H(+) + sulfate
RHEA:17261	skos:prefLabel	"arylsulfatase (type I)"
REACT:R-HSA-6804035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2O3 diffuses to phagosome (Homo sapiens)
REACT:R-BTA-429683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Bos taurus)
RHEA:36746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptadecasphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine
REACT:R-SSC-3296244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUCNR1 binds SUCCA (Sus scrofa)
RHEA:22876	skos:prefLabel	"mandelamide amidase"
RHEA:22876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mandelamide amidase"
RHEA:22876	skos:altLabel	"Mandelamide hydrolase"
RHEA:22876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelamide + H2O = (R)-mandelate + NH4(+)
REACT:R-MMU-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Mus musculus)
RHEA:23475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 alpha,alpha'-trehalose 6-mycolate <=> alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose
REACT:R-SSC-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Sus scrofa)
REACT:R-HSA-9665707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR (Homo sapiens)
RHEA:47704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + iso-precytochalasin + NADPH + O2 = cytochalasin Z16 + H2O + NADP(+)
REACT:R-CEL-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Caenorhabditis elegans)
REACT:R-MMU-389026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galanin receptors can bind galanin (Mus musculus)
RHEA:23399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phloretin <=> 1,3,5-trihydroxybenzene + H(+) + phloretate
REACT:R-DME-209307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT92E dimer activates transcription (Drosophila melanogaster)
REACT:R-DME-6798374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DYRK2 phosphorylates TP53 (Drosophila melanogaster)
REACT:R-CFA-990489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-13 is a dimer (Canis familiaris)
RHEA:20680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alizarin + UDP-alpha-D-glucose <=> 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP
RHEA:28914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-lysine(out) <=> H(+)(in) + L-lysine(in)
RHEA:17198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate + O2 => 2 4-hydroxyphenylacetate + 2 CO2
RHEA:36266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyurea + O-acetyl-L-serine <=> acetate + H(+) + O-ureido-L-serine
RHEA:10008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O
RHEA:10663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] <=> D-seryl-[protein]
REACT:R-MMU-372529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of acetylcholine at the synapse (Mus musculus)
RHEA:72720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)
RHEA:70595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DRE-5638333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Danio rerio)
REACT:R-CFA-265301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticotropin cleavage from POMC (Canis familiaris)
REACT:R-SSC-4641236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates FZD to potentiate WNT signaling (Sus scrofa)
RHEA:16971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-beta-L-rhamnose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose
REACT:R-MMU-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Mus musculus)
REACT:R-BTA-450971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Bos taurus)
REACT:R-HSA-169719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted CD14 binds LPS (Homo sapiens)
REACT:R-DME-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Drosophila melanogaster)
RHEA:35609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetyl + H(+) + NADPH => acetoin + NADP(+)
RHEA:14934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate
RHEA:33252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 sucrose => 6-kestotriose + beta-D-glucose
REACT:R-DDI-5693615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Dictyostelium discoideum)
GO:0033410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAC codon-amino acid adaptor activity
GO:0033410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UAC codon-amino acid adaptor activity
GO:0033410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine tRNA
GO:0102528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8,4'-trihydroxyflavone methyltransferase activity
REACT:R-DRE-8983870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Danio rerio)
REACT:R-HSA-8865498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark (Homo sapiens)
GO:0043994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H3-K23 specific)
GO:0043994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K23 acetyltransferase activity
GO:0043994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H3-K23 specific)
GO:0043994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K23 acetyltransferase activity
GO:0043994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H3-K23 specific)
RHEA:69584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + inosine = guanosine + IMP
REACT:R-BTA-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Bos taurus)
REACT:R-DRE-8873946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD3 deubiquitinates PTEN (Danio rerio)
REACT:R-BTA-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
REACT:R-SSC-5696365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Sus scrofa)
REACT:R-SSC-198563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO1 dioxygenates L-Trp to NFK (Sus scrofa)
RHEA:71477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucyl-L-leucine + neurotensin(1-11) => H2O + neurotensin
REACT:R-MMU-8944242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVII (Mus musculus)
RHEA:28397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-L-glutamate <=> L-alanyl-D-glutamate
REACT:R-CFA-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Canis familiaris)
REACT:R-MMU-4088264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Mus musculus)
RHEA:54560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP = a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)
REACT:R-RNO-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Rattus norvegicus)
REACT:R-RNO-6785762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL13RA1 binds TYK2 (Rattus norvegicus)
REACT:R-DRE-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Danio rerio)
REACT:R-SSC-174202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Securin (Sus scrofa)
RHEA:70948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan(in) => L-tryptophan(out)
RHEA:61603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbD protein]-disulfide + [protein]-dithiol <=> [DsbB protein]-dithiol + [protein]-disulfide
RHEA:17972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
RHEA:29513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-valencene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:70795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-lysine(out) = H(+)(out) + L-lysine(in)
RHEA:23526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkyl cinnamate + beta-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol
RHEA:14564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-piperoyl-CoA + piperidine <=> CoA + H(+) + N-[(E,E)-piperoyl]piperidine
REACT:R-XTR-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Xenopus tropicalis)
RHEA:12499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(2+) + 4 H2O + O2 <=> 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide
REACT:R-MMU-2130486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoating of clathrin-coated vesicles and fusion with endosomes (Mus musculus)
GO:0102520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine O-3-phosphate phosphatase activity
REACT:R-HSA-5665809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)
RHEA:71672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamine(out) + H(+)(out) => glycyl-L-glutamine(in) + H(+)(in)
RHEA:50757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + reduced [flavodoxin] => 2 H(+) + NADPH + oxidized [flavodoxin]
REACT:R-XTR-6814165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates CSA to HTAU (Xenopus tropicalis)
REACT:R-HSA-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Homo sapiens)
RHEA:37204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
REACT:R-HSA-3000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PLK1 (Homo sapiens)
REACT:R-DRE-1006143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C3b (Danio rerio)
REACT:R-DDI-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Dictyostelium discoideum)
REACT:R-SCE-1482629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)
RHEA:39901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganin + H(+) + UDP => 7-deoxyloganetin + UDP-alpha-D-glucose
RHEA:24691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + eugenol + NADP(+) => (E)-coniferyl acetate + NADPH
REACT:R-CFA-6788523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to Complex I subunits (Canis familiaris)
RHEA:34836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine => a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine
RHEA:69830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5362459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Gallus gallus)
REACT:R-HSA-1250253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP is released from oxidized thioredoxin (Homo sapiens)
REACT:R-XTR-5686704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates DCLRE1C (Xenopus tropicalis)
REACT:R-SSC-1169397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ISG15 by UBA7 E1 ligase (Sus scrofa)
RHEA:26078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanesulfonate + NADH + O2 => formaldehyde + H2O + NAD(+) + sulfite
GO:0030758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,7-dimethylquercetin 4'-O-methyltransferase"
GO:0030758	skos:altLabel	"3,7-dimethylquercitin 4'-O-methyltransferase"
GO:0030758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity
GO:0030758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 4'-methyltransferase activity
GO:0030758	skos:altLabel	"flavonol 4'-O-methyltransferase"
GO:0030758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7-dimethylquercitin 4'-O-methyltransferase activity
GO:0030758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4'-OMT activity
GO:0030758	skos:altLabel	"flavonol 4'-methyltransferase"
GO:0030758	skos:prefLabel	"3,7-dimethylquercetin 4'-O-methyltransferase"
GO:0030758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity
GO:0030758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,7-dimethylquercetin 4'-O-methyltransferase activity
GO:0030758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 4'-O-methyltransferase activity
GO:0030758	skos:altLabel	"4'-OMT"
GO:0030758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Homo sapiens)
REACT:R-DRE-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Danio rerio)
RHEA:60404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-SSC-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Sus scrofa)
REACT:R-CFA-5654569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS2 (Canis familiaris)
REACT:R-CFA-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Canis familiaris)
REACT:R-BTA-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
RHEA:11513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicyl alcohol + UDP-alpha-D-glucose => H(+) + salicin + UDP
GO:0140312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cargo adaptor activity
GO:0140312	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endocytic adaptor activity
RHEA:64522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde => acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA
RHEA:68378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuccinamate + glycine => glyoxylate + L-asparagine
RHEA:58992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamaldehyde + H2O + O2 = (E)-cinnamate + H(+) + H2O2
REACT:R-PFA-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-HSA-375148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with Neurocan (Homo sapiens)
RHEA:34129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabigerolate + diphosphate => (2E)-geranyl diphosphate + olivetolate
RHEA:71475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11)
REACT:R-MMU-5693575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PKcs autophosphorylates (Mus musculus)
RHEA:68241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) + Na(+)(in) => L-methionine(out) + Na(+)(out)
REACT:R-DME-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Drosophila melanogaster)
RHEA:54441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4S)-2,3-dehydroflavan-3,4-diol + H(+) => a 4-H-anthocyanidin with a 3-hydroxy group + H2O
RHEA:23245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermidine + S-methyl-5'-thioadenosine
REACT:R-RNO-202325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Gads to LAT (Rattus norvegicus)
RHEA:22174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + sucrose 6(F)-phosphate + UDP => beta-D-fructose 6-phosphate + UDP-alpha-D-glucose
RHEA:10387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate <=> beta-cyclopiazonate + diphosphate
RHEA:56617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene => 1,2,4-trichlorobenzene + chloride + H(+)
RHEA:31473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP => beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose
RHEA:44597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + H2O => a fatty acid + H(+) + holo-[ACP]
REACT:R-DME-5692283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Drosophila melanogaster)
REACT:R-SSC-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Sus scrofa)
REACT:R-DRE-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Danio rerio)
RHEA:43580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-arginine = AH2 + iminoarginine
RHEA:36252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + AMP + diphosphate
RHEA:49084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] = (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:49084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-pluviatolide synthase"
RHEA:49084	skos:altLabel	"CYP719A23"
RHEA:49084	skos:prefLabel	"(-)-pluviatolide synthase"
REACT:R-DRE-1295622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds CBL (Danio rerio)
RHEA:46812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-BTA-2029271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
REACT:R-HSA-9027033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA (Homo sapiens)
REACT:R-HSA-975111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9   (Homo sapiens)
REACT:R-BTA-421416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proglucagon translocates from the ER Lumen to secretory granules (Bos taurus)
REACT:R-GGA-3371360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
REACT:R-RNO-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Rattus norvegicus)
REACT:R-GGA-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Gallus gallus)
REACT:R-RNO-9009541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds to TFF1 gene promoter (Rattus norvegicus)
RHEA:12799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + H2O + scopolamine + succinate => (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2
RHEA:45540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-DME-8870352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-CFA-3000433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PML with SUMO3 (Canis familiaris)
REACT:R-SPO-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Schizosaccharomyces pombe)
REACT:R-BTA-8983300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Bos taurus)
RHEA:67223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH
EC:3.1.6.14	skos:prefLabel	"N-acetylglucosamine-6-sulfatase"
EC:3.1.6.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosamine-6-sulfatase"
EC:3.1.6.14	skos:altLabel	"chondroitinsulfatase"
EC:3.1.6.14	skos:altLabel	"glucosamine-6-sulfatase"
REACT:R-HSA-9694444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E and N are recruited to the M lattice (Homo sapiens)
RHEA:50673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O => [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose
RHEA:61187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercitrin + UDP-beta-L-rhamnose <=> H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP
REACT:R-BTA-6786205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Bos taurus)
REACT:R-MMU-139895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAK protein (Mus musculus)
REACT:R-CEL-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Caenorhabditis elegans)
RHEA:14229	skos:altLabel	"5,10-methylenetetrahydrofolate reductase"
RHEA:14229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:14229	skos:prefLabel	"methylenetetrahydrofolate reductase (ferredoxin)"
RHEA:14229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylenetetrahydrofolate reductase (ferredoxin)"
RHEA:38795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
GO:0034556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrobenzoate nitroreductase activity
RHEA:71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanine(out) + Na(+)(out) = H(+)(out) + L-alanine(in) + Na(+)(in)
REACT:R-MMU-2028724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind YAP1 (Mus musculus)
REACT:R-RNO-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Rattus norvegicus)
REACT:R-BTA-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Bos taurus)
REACT:R-XTR-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Xenopus tropicalis)
REACT:R-HSA-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Homo sapiens)
REACT:R-CFA-5138432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 is phosphorylated by PKC (Canis familiaris)
RHEA:61605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-dithiol + [DsbB protein]-disulfide => [DsbA protein]-disulfide + [DsbB protein]-dithiol
RHEA:13626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6)-dimethylallyladenine => 3-methyl-2-butenal + adenine + AH2
REACT:R-XTR-8849042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS3 (Xenopus tropicalis)
REACT:R-MMU-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Mus musculus)
GO:0018551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trithionate:(acceptor) oxidoreductase activity
GO:0018551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dissimilatory-type sulfite reductase activity
GO:0018551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dissimilatory sulfite reductase activity
GO:0018551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trithionate:acceptor oxidoreductase activity
GO:0018551	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	desulfoviridin activity
GO:0018551	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	desulforubidin activity
GO:0018551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogensulphite reductase activity
GO:0018551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogensulfite reductase activity
GO:0018551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bisulfite reductase activity
GO:0018551	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	desulfofuscidin activity
RHEA:48766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acetyl-3-devinylchlorophyllide a + H(+) + NADH => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+)
RHEA:22375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + propionate 3-nitronate <=> 3-oxopropanoate + H(+) + H2O2 + nitrite
RHEA:34540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + tellurite => methanetellurite + S-adenosyl-L-homocysteine
RHEA:56753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:16387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + hydroquinone + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH + O2
RHEA:35460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + NAD(+) => cholest-5-en-3-one + H(+) + NADH
REACT:R-DRE-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Danio rerio)
REACT:R-SPO-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Schizosaccharomyces pombe)
GO:0034860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-mercaptobenzothiazole desulfurase activity
REACT:R-RNO-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Rattus norvegicus)
RHEA:27438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione amide + H2O2 => glutathione amide disulfide + 2 H2O
REACT:R-DME-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Drosophila melanogaster)
REACT:R-XTR-5358336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB forms mixed disulphides with Hh precursors (Xenopus tropicalis)
REACT:R-BTA-392870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gs activation by prostacyclin receptor (Bos taurus)
REACT:R-CFA-6792863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)
REACT:R-XTR-3239019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK5 (Xenopus tropicalis)
RHEA:15350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + N(2)-acetyl-L-ornithine => L-ornithine + N-acetyl-L-glutamate
RHEA:42039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NAD(+) <=> 7-oxolithocholate + H(+) + NADH
REACT:R-HSA-381290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG:RXRA heterodimer binds to PPARG corepressors (Homo sapiens)
RHEA:60105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein] => (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]
REACT:R-MMU-1474210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP14 (Mus musculus)
REACT:R-CFA-8983835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Canis familiaris)
RHEA:68973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + sn-glycerol 3-phosphate => AH2 + dihydroxyacetone phosphate
REACT:R-DRE-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Danio rerio)
RHEA:18151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + D-galactosamine 6-phosphate => H2O + N-acetyl-D-galactosamine 6-phosphate
REACT:R-CFA-9008696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) translocates from the cytosol to the nucleus (Canis familiaris)
REACT:R-RNO-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Rattus norvegicus)
RHEA:45116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-ipsdienol + NADP(+) = H(+) + ipsdienone + NADPH
RHEA:72805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + N(omega)-methyl-L-arginine(out) => L-arginine(out) + N(omega)-methyl-L-arginine(in)
RHEA:43877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate
REACT:R-SSC-9705794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 binds SRD5A2 inhibitors (Sus scrofa)
REACT:R-SSC-8954082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds the PRC1 complex (Sus scrofa)
REACT:R-DRE-5607721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NIK (Danio rerio)
RHEA:23591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate + succinyl-CoA <=> oxalyl-CoA + succinate
REACT:R-SSC-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Sus scrofa)
RHEA:11884	skos:altLabel	"glucocorticosteroid sulfotransferase"
RHEA:11884	skos:prefLabel	"cortisol sulfotransferase"
RHEA:11884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)
RHEA:11884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cortisol sulfotransferase"
RHEA:50719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfone + FMNH2 + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate
REACT:R-CFA-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Canis familiaris)
REACT:R-DME-1250315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB4 homodimers (Drosophila melanogaster)
REACT:R-HSA-5362441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)
REACT:R-GGA-204871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb2 (Gallus gallus)
RHEA:62460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate
RHEA:62460	skos:prefLabel	"3,4-dihydroxybenzoate--[aryl-carrier protein] ligase"
RHEA:62460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,4-dihydroxybenzoate--[aryl-carrier protein] ligase"
RHEA:66941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine => 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B
REACT:R-DDI-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Dictyostelium discoideum)
RHEA:29706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine(in) <=> L-valine(out)
RHEA:43769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkylamine + L-glutaminyl-[protein] => N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)
REACT:R-CEL-77594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Caenorhabditis elegans)
REACT:R-HSA-110141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Homo sapiens)
REACT:R-HSA-201691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)
GO:1990473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTS binding
GO:1990473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ciliary targeting signal binding
REACT:R-BTA-5692408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPR2 binds NPPC (Bos taurus)
REACT:R-GGA-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Gallus gallus)
RHEA:19175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene + O2
REACT:R-CEL-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Caenorhabditis elegans)
RHEA:47509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5beta-cholan-24-oate + H(+) + NADH => isolithocholate + NAD(+)
REACT:R-MMU-5686315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Mus musculus)
REACT:R-RNO-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Rattus norvegicus)
REACT:R-SSC-193709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)
REACT:R-HSA-159752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Homo sapiens)
REACT:R-BTA-448629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33 binds IL1RL1 (Bos taurus)
REACT:R-MMU-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Mus musculus)
RHEA:62943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-acetylcytosine <=> acetate + cytosine + H(+)
REACT:R-DME-6810843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin binds periplakin (Drosophila melanogaster)
REACT:R-RNO-2028644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Rattus norvegicus)
REACT:R-GGA-8952058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 binds RUNX3 and displaces EP300 (Gallus gallus)
REACT:R-GGA-3640861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 ubiquitinates ADP-ribosylated AXIN (Gallus gallus)
REACT:R-RNO-9018894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Rattus norvegicus)
RHEA:27548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + FAD + H(+) + H2O => anthranilate + FADH2 + O2
REACT:R-HSA-9653894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CHAC1 (Homo sapiens)
REACT:R-CFA-77345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Canis familiaris)
REACT:R-DRE-388863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Danio rerio)
REACT:R-CEL-177922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR dimerization (Caenorhabditis elegans)
GO:0008686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-2-butanone-4-phosphate synthase activity
REACT:R-CFA-6799466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 dimerizes (Canis familiaris)
RHEA:23579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Dictyostelium discoideum)
RHEA:42783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine
REACT:R-SPO-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Schizosaccharomyces pombe)
REACT:R-HSA-5654404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds SHC1 (Homo sapiens)
RHEA:51828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)
REACT:R-DRE-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Danio rerio)
REACT:R-HSA-8942302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP13 cleaves OPTC (Homo sapiens)
RHEA:18706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP
RHEA:13115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-hydroxy-2-acetamidofluorene + NADPH => 2-acetamidofluorene + H2O + NADP(+)
RHEA:51800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadlupulone + dimethylallyl diphosphate = adlupulone + diphosphate + H(+)
REACT:R-GGA-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Gallus gallus)
RHEA:45158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + CoA + H(+) => 3-oxopropanoyl-CoA + H2O
REACT:R-RNO-9705713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 dehydrogenates TEST to DHTEST (Rattus norvegicus)
RHEA:52898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate => 2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin
RHEA:66134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O
REACT:R-MMU-873924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IFNGR1 by JAK kinases (Mus musculus)
REACT:R-RNO-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Rattus norvegicus)
REACT:R-GGA-5607043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa associates with cell membrane (Gallus gallus)
RHEA:28905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(out) + H(+)(out) => D-alanine(in) + H(+)(in)
GO:0005172	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vascular endothelial growth factor receptor ligand
GO:0005172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF receptor binding
GO:0005172	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vascular endothelial growth factor
GO:0005172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR binding
GO:0005172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vascular endothelial growth factor receptor binding
GO:0051736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent polyribonucleotide kinase activity
GO:0051736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity
GO:0051736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyribonucleotide 5'-hydroxyl-kinase activity
GO:0051736	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP-dependent polynucleotide 5'-hydroxyl-kinase activity
GO:0051736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent RNA 5'-hydroxyl-kinase activity
GO:0051736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent RNA kinase activity
GO:0051736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
REACT:R-MMU-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Mus musculus)
RHEA:59088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-histidine 2-aminobutanoyltransferase"
RHEA:59088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine
RHEA:59088	skos:prefLabel	"D-histidine 2-aminobutanoyltransferase"
RHEA:11394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + phosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
RHEA:46861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP
REACT:R-SPO-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Schizosaccharomyces pombe)
RHEA:26038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Rattus norvegicus)
GO:0045340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hg ion binding
GO:0045340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mercury ion binding
GO:0045340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mercury binding
REACT:R-HSA-622420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Homo sapiens)
RHEA:12355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulono-1,4-lactone + O2 <=> H2O2 + L-xylo-hex-3-ulonolactone
REACT:R-HSA-388817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICOS binds ICOSL/B7-H2 (Homo sapiens)
REACT:R-HSA-6784628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)
REACT:R-XTR-159757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)
REACT:R-HSA-9008110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
RHEA:62574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine
REACT:R-SSC-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Sus scrofa)
RHEA:40481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
REACT:R-RNO-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Rattus norvegicus)
RHEA:12808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-canadine + S-adenosyl-L-methionine <=> (S)-N-methylcanadine + S-adenosyl-L-homocysteine
RHEA:69991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + NADP(+) = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH
REACT:R-MMU-2176475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Mus musculus)
REACT:R-XTR-2046092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Xenopus tropicalis)
RHEA:17807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => H2O + S-adenosyl-L-homocysteine
REACT:R-XTR-6782106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates SNX3, CFTR (Xenopus tropicalis)
RHEA:18634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + H2O + hydrogencarbonate + L-glutamine => 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate
RHEA:11204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase"
RHEA:11204	skos:altLabel	"propionyl-CoA holocarboxylase synthetase"
RHEA:11204	skos:altLabel	"biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase"
RHEA:11204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
RHEA:11204	skos:prefLabel	"biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase"
RHEA:11204	skos:altLabel	"holocarboxylase synthetase"
REACT:R-CFA-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Canis familiaris)
RHEA:32879	skos:prefLabel	"5-exo-hydroxycamphor dehydrogenase"
RHEA:32879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-exo-hydroxycamphor dehydrogenase"
RHEA:32879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R,5R)-5-hydroxycamphor + NAD(+) = (1R,4R)-bornane-2,5-dione + H(+) + NADH
RHEA:51536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP
REACT:R-DRE-352108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Danio rerio)
REACT:R-CEL-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Caenorhabditis elegans)
REACT:R-RNO-8849068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARHGAP35 (Rattus norvegicus)
REACT:R-CEL-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)
REACT:R-BTA-1482679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)
RHEA:58994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) + H2O2 => (E)-cinnamaldehyde + H2O + O2
REACT:R-RNO-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Rattus norvegicus)
RHEA:17998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-2 + S-adenosyl-L-methionine => Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine
GO:0097351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toxin sequestering activity
GO:0097351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	toxin-antitoxin pair type II binding
GO:0097351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	toxin-antitoxin pair type I binding
REACT:R-CEL-69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk1 (Caenorhabditis elegans)
REACT:R-CEL-209910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is taken up by thyroid epithelial cells (Caenorhabditis elegans)
REACT:R-SCE-1482689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)
REACT:R-CFA-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Canis familiaris)
REACT:R-DRE-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Danio rerio)
RHEA:60731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citral + H2O + NADP(+) <=> 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH
REACT:R-BTA-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Bos taurus)
REACT:R-HSA-8871376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds PI3P (Homo sapiens)
EC:4.3.99.-	skos:prefLabel	"Other carbon-nitrogen lyases"
EC:4.3.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other carbon-nitrogen lyases"
RHEA:48062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O
RHEA:30296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + pyruvate => GDP + H(+) + phosphoenolpyruvate
RHEA:32798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-cysteine(out) <=> ADP + H(+) + L-cysteine(in) + phosphate
RHEA:50567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]
REACT:R-SPO-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Schizosaccharomyces pombe)
GO:0009018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose glucosyltransferase activity
GO:0009018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sucrose phosphorylase"
GO:0009018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:phosphate alpha-D-glucosyltransferase activity
GO:0009018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sucrose = alpha-D-glucose 1-phosphate + D-fructose
GO:0009018	skos:prefLabel	"sucrose phosphorylase"
GO:0009018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose phosphorylase activity
GO:0009018	skos:altLabel	"disaccharide glucosyltransferase"
GO:0009018	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	disaccharide glucosyltransferase activity
GO:0009018	skos:altLabel	"sucrose glucosyltransferase"
RHEA:59197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP => AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]
RHEA:40017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-epi-manool + diphosphate => (+)-copalyl diphosphate + H2O
RHEA:41894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-[ACP] + H2O => (3R)-hydroxytetradecanoyl-[ACP]
REACT:R-BTA-5229283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCNs bind lipids (Bos taurus)
REACT:R-HSA-2395992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,4S-IRF3 is dimerized (Homo sapiens)
REACT:R-RNO-8951499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides on to class I MHC (Rattus norvegicus)
REACT:R-RNO-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Rattus norvegicus)
REACT:R-SPO-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Schizosaccharomyces pombe)
REACT:R-HSA-202710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MERTK receptor binds ligands (Gas6 or Protein S) (Homo sapiens)
REACT:R-HSA-9036037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective IDUA does not hydrolyse Heparan sulfate chain(1) (Homo sapiens)
RHEA:56678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H(+) + NADPH => dihydroferuloyl-CoA + NADP(+)
REACT:R-MMU-191972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol is 7alpha-hydroxylated (Mus musculus)
REACT:R-CFA-5607737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 oligomerizes (Canis familiaris)
RHEA:67633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] => a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:36901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine => guanosine(37) in tRNA + S-adenosyl-L-methionine
REACT:R-SPO-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Schizosaccharomyces pombe)
RHEA:72688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol(out) => all-trans-retinol(in)
GO:0004753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine-2-oxoglutarate reductase activity
GO:0004753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine dehydrogenase activity
GO:0004753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine-ketoglutarate reductase activity
RHEA:11924	skos:prefLabel	"lactosylceramide 4-alpha-galactosyltransferase"
RHEA:11924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactosylceramide 4-alpha-galactosyltransferase"
RHEA:11924	skos:altLabel	"Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase"
RHEA:11924	skos:altLabel	"histo-blood group P(k) UDP-galactose"
RHEA:11924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = globoside Gb3Cer (d18:1(4E)) + H(+) + UDP
RHEA:11924	skos:altLabel	"globotriaosylceramide/CD77 synthase"
RHEA:29262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate(out) + succinate(in) <=> (2R,3R)-tartrate(in) + succinate(out)
REACT:R-HSA-198599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MDM2 (Homo sapiens)
RHEA:28141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + streptothricin F <=> streptothricin F acid
RHEA:67804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 = CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate
REACT:R-RNO-9686920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 ubiquitinates RIPK3 at K363 (Rattus norvegicus)
REACT:R-BTA-6799202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)
REACT:R-XTR-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Xenopus tropicalis)
RHEA:56645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in mRNA => a pseudouridine in mRNA
REACT:R-HSA-9731661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Homo sapiens)
REACT:R-DRE-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Danio rerio)
RHEA:63506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-dihydrodaunorubicin + NADP(+) => daunorubicin + H(+) + NADPH
GO:0015561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnose:hydrogen symporter activity
GO:0015561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnose:proton symporter activity
REACT:R-CFA-389652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Canis familiaris)
RHEA:11665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate => 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)
RHEA:17066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + ATP => (R)-5-phosphomevalonate + ADP + H(+)
REACT:R-XTR-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Xenopus tropicalis)
RHEA:38309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
RHEA:61420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-cis,cis-nepetalactol synthase"
RHEA:61420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol = cis-cis-nepetalactol
RHEA:61420	skos:prefLabel	"(+)-cis,cis-nepetalactol synthase"
REACT:R-SSC-6809393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filaments bind cell-cell adhesion complexes (Sus scrofa)
REACT:R-SPO-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Schizosaccharomyces pombe)
GO:0047879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythronolide synthase activity
GO:0047879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)
GO:0047879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythronolide condensing enzyme activity
REACT:R-SSC-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Sus scrofa)
REACT:R-BTA-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Bos taurus)
REACT:R-DRE-8873834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 transports PC from ER membrane to lamellar body membrane (Danio rerio)
REACT:R-PFA-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Plasmodium falciparum)
REACT:R-BTA-8987129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Bos taurus)
RHEA:28478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate(in) + H(+)(in) = galactarate(out) + H(+)(out)
REACT:R-DME-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Drosophila melanogaster)
REACT:R-MMU-5624948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF17 enters the cilium (Mus musculus)
REACT:R-HSA-5662851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective DCXR does not reduce L-xylulose to xylitol (Homo sapiens)
REACT:R-GGA-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Gallus gallus)
RHEA:10767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate
REACT:R-HSA-8855381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dephosphorylates ZAP70 (Homo sapiens)
REACT:R-CFA-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Canis familiaris)
REACT:R-CFA-9611852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB3 bind ADR,NAd (Canis familiaris)
REACT:R-RNO-5654428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates SHC1 (Rattus norvegicus)
RHEA:22667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-O-(trans-sinapoyl)-beta-D-glucose <=> 1,2-di-O-sinapoyl beta-D-glucose + D-glucose
REACT:R-HSA-9014295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)
REACT:R-XTR-374207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled estrogen receptor 1 binds estrogen non-classically (Xenopus tropicalis)
REACT:R-HSA-879914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3 stimulation induces Vav binding to Tec kinase (Homo sapiens)
RHEA:21798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-beta-L-rhamnose + NADP(+)
RHEA:54348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:72547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + taurocholate(out) = 2-oxoglutarate(out) + taurocholate(in)
RHEA:72341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+)
RHEA:49274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:21083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-methionine <=> diphosphate + phosphate + S-adenosyl-L-methionine
RHEA:53639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine
GO:0102931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z,E)-alpha- farnesene synthase activity
REACT:R-SSC-8865265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds MYC and KDM5B (Sus scrofa)
RHEA:48365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
REACT:R-CFA-202248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma1 (Canis familiaris)
REACT:R-SSC-2032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ), TBX5, and PCAF form a complex (Sus scrofa)
RHEA:29548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N-acetyl-alpha-D-glucosamine => 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP
RHEA:40709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate
REACT:R-BTA-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Bos taurus)
REACT:R-CFA-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Canis familiaris)
RHEA:20818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoglycyrrhetinate + H(+) + NADPH => 3alpha-hydroxyglycyrrhetinate + NADP(+)
REACT:R-GGA-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Gallus gallus)
REACT:R-XTR-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Xenopus tropicalis)
RHEA:47608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA
RHEA:59515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylsalicylate + L-seryl-[protein] <=> O-acetyl-L-seryl-[protein] + salicylate
RHEA:13487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate => 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine
REACT:R-SSC-176517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to PREG (Sus scrofa)
REACT:R-SSC-2730861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Sus scrofa)
RHEA:50769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine
RHEA:16987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + maleylacetate + NADPH => 3-oxoadipate + NADP(+)
RHEA:13713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + succinate = a ubiquinol + fumarate
RHEA:55546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => L-lysyl-[citrate synthase] + S-adenosyl-L-methionine
RHEA:61708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-seryl-5'-AMP = AMP + L-seryl-[peptidyl-carrier protein]
GO:0102158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-long-chain 3-hydroxyacyl-CoA dehydratase activity
RHEA:40829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O
RHEA:12048	skos:prefLabel	"3-oxoadipate CoA-transferase"
RHEA:12048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxoadipate CoA-transferase"
RHEA:12048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate
RHEA:12048	skos:altLabel	"beta-ketoadipate:succinyl-CoA transferase"
REACT:R-MMU-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Mus musculus)
REACT:R-HSA-205286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS interacts with p-KIT (Homo sapiens)
REACT:R-RNO-390427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Rattus norvegicus)
RHEA:70385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoyl-3-oxosphinganine => 3-oxosphinganine + hexadecanoyl-CoA
RHEA:49174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine
REACT:R-RNO-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Rattus norvegicus)
RHEA:30936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nicotinate beta-D-ribonucleotide => beta-D-ribosylnicotinate + phosphate
GO:0016416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)
GO:0016416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-palmitoyltransferase activity
REACT:R-MMU-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Mus musculus)
RHEA:48809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
RHEA:51463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-glutamate <=> (9Z)-octadecenoate + L-glutamate
REACT:R-SSC-8875531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS4 (Sus scrofa)
REACT:R-BTA-8852317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GTSE1 (Bos taurus)
GO:0046592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyamine oxidase activity
GO:0046592	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-N-acetylspermidine:oxygen oxidoreductase (deaminating)
GO:0046592	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	N1-acetylspermidine:oxygen oxidoreductase (deaminating)
REACT:R-SSC-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Sus scrofa)
GO:0008930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MTA nucleosidase activity
GO:0008930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MeSAdo nucleosidase activity
GO:0008930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthioadenosine nucleosidase activity
GO:0008930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-methyl-5'-thioadenosine adeninehyrolase activity
GO:0008930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylthioadenosine methylthioribohydrolase activity
GO:0008930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-methylthioadenosine nucleosidase activity
EC:2.7.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other protein kinases"
EC:2.7.99.-	skos:prefLabel	"Other protein kinases"
REACT:R-HSA-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
RHEA:37976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + homogentisate + phytyl diphosphate => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate
REACT:R-GGA-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Gallus gallus)
REACT:R-RNO-1169405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein phosphatase 1 beta (PP2CB) (Rattus norvegicus)
REACT:R-MMU-216076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Mus musculus)
RHEA:62601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate
REACT:R-RNO-177942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EGF ligand (Rattus norvegicus)
RHEA:47531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isocholate + NADP(+)
RHEA:18150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-galactosamine 6-phosphate => acetate + D-galactosamine 6-phosphate
REACT:R-XTR-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Xenopus tropicalis)
RHEA:44387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Homo sapiens)
RHEA:29585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(out) + H(+)(in) => guanosine(in) + H(+)(out)
EC:1.1.1.53	skos:prefLabel	"3alpha(or 20beta)-hydroxysteroid dehydrogenase"
EC:1.1.1.53	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha(or 20beta)-hydroxysteroid dehydrogenase"
EC:1.1.1.53	skos:altLabel	"(R)-20-hydroxysteroid dehydrogenase"
EC:1.1.1.53	skos:altLabel	"cortisone reductase"
REACT:R-HSA-8950634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of capping actin protein of muscle Z-line alpha subunit 1 (Homo sapiens)
RHEA:54114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + selina-4(15),7(11)-diene => (2E,6E)-farnesyl diphosphate
REACT:R-DRE-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Danio rerio)
REACT:R-HSA-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)
REACT:R-CEL-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
GO:0016860	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intramolecular oxidoreductase activity, other intramolecular oxidoreductases
GO:0016860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular isomerase activity
GO:0016860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular oxidoreductase activity
RHEA:34181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + H(+) + mycophenolate => H2O + mycophenolic acid O-acyl-beta-D-glucuronide
REACT:R-DRE-5653756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM25 binds monoUb:164-PCNA (Danio rerio)
REACT:R-BTA-176664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + PAPS => estrone 3-sulfate + PAP (Bos taurus)
REACT:R-CEL-5225649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP7 binds histone H3 (Caenorhabditis elegans)
RHEA:28585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dUDP <=> ADP + dUTP
GO:0034538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylsalicylaldehyde dehydrogenase activity
REACT:R-HSA-9617853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)
REACT:R-HSA-9708859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Homo sapiens)
RHEA:45290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin G2 => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2
REACT:R-BTA-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Bos taurus)
RHEA:20586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin
RHEA:46829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH
REACT:R-GGA-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Gallus gallus)
REACT:R-RNO-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)
RHEA:52335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] <=> 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]
REACT:R-GGA-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Gallus gallus)
RHEA:10651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 <=> 6-hydroxyhexan-6-olide + H2O + NADP(+)
REACT:R-HSA-4088205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasma membrane glycoconjugates translocate to the cytosol (Homo sapiens)
REACT:R-XTR-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Xenopus tropicalis)
REACT:R-GGA-3239019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK5 (Gallus gallus)
RHEA:14628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) <=> [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)
REACT:R-SSC-9024766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Sus scrofa)
REACT:R-HSA-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Homo sapiens)
RHEA:67083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acid(in) + ATP + H2O <=> a very long-chain fatty acid(out) + ADP + H(+) + phosphate
RHEA:55316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + hydrogen sulfide + 3 NAD(+) = 4 H(+) + 3 NADH + sulfite
RHEA:39210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexacosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexacosanoyl-CoA + NADP(+)
RHEA:15625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-6B + NAD(+) = Co-precorrin-6A + H(+) + NADH
RHEA:15625	skos:prefLabel	"cobalt-precorrin-6A reductase"
RHEA:15625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobalt-precorrin-6A reductase"
RHEA:23874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactaldehyde + H(+) + NADH => (R)-propane-1,2-diol + NAD(+)
REACT:R-MMU-9693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds 5HT (Mus musculus)
RHEA:43962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA
REACT:R-GGA-8876868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE1 cleaves EDN1(53-90) (Gallus gallus)
REACT:R-GGA-389762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PD-1 (Gallus gallus)
REACT:R-CFA-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Canis familiaris)
REACT:R-GGA-5607751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes (Gallus gallus)
RHEA:56078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose
GO:0102856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity
REACT:R-HSA-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
REACT:R-DME-975139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Drosophila melanogaster)
REACT:R-HSA-8939904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ESR1 binds the RUNX2 gene promoter (Homo sapiens)
REACT:R-DRE-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Danio rerio)
RHEA:14335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol
RHEA:22065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-ergosta-7,22-diene-3beta,5-diol => ergosterol + H2O
RHEA:62461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate
REACT:R-RNO-8848726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates BCAR1 (Rattus norvegicus)
REACT:R-MMU-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Mus musculus)
RHEA:62632	skos:prefLabel	"glutathione-dependent peroxiredoxin"
RHEA:62632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione-dependent peroxiredoxin"
RHEA:62632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
RHEA:71152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one => (E)-caffeoylpyruvate + CO2 + hnu
REACT:R-SSC-3781011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Sus scrofa)
RHEA:10254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + phosphate => H(+) + hydrogen sulfide + O-phospho-L-serine
REACT:R-CEL-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Caenorhabditis elegans)
RHEA:15130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:43528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NAD(+) = 2-aminomalonate semialdehyde + H(+) + NADH
REACT:R-BTA-8938815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 polyubiquitinates RRAGA (Bos taurus)
RHEA:70794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-ornithine(out) <=> H(+)(out) + L-ornithine(in)
REACT:R-HSA-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Homo sapiens)
REACT:R-GGA-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Gallus gallus)
RHEA:44923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH <=> (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)
RHEA:47816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)
RHEA:33469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+) => 5-dehydroepisterol + H(+) + NADPH + O2
REACT:R-GGA-433967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized Phospho-IRF3 is Transported To The Nucleus (Gallus gallus)
REACT:R-MMU-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)
REACT:R-SPO-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Schizosaccharomyces pombe)
RHEA:62109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-BTA-418172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB2 (Bos taurus)
REACT:R-HSA-5218847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 binds NCK (Homo sapiens)
REACT:R-DME-2046265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the keratan chain (Drosophila melanogaster)
REACT:R-DME-888589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GABA at the synapse (Drosophila melanogaster)
REACT:R-HSA-5632386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP63/TP53 stimulates transcription of DDIT4 gene (Homo sapiens)
RHEA:65380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine
GO:0009027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tartrate:NAD+ oxidoreductase activity
GO:0009027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mesotartrate dehydrogenase activity
GO:0009027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tartrate dehydrogenase activity
REACT:R-BTA-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Bos taurus)
REACT:R-CEL-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Caenorhabditis elegans)
REACT:R-SPO-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Schizosaccharomyces pombe)
REACT:R-GGA-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Gallus gallus)
REACT:R-SSC-6784323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Sus scrofa)
REACT:R-CFA-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Canis familiaris)
RHEA:41708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)
REACT:R-CEL-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Caenorhabditis elegans)
REACT:R-GGA-8932955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Gallus gallus)
REACT:R-DRE-9008285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Danio rerio)
RHEA:46275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-5263616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)
REACT:R-XTR-400092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Xenopus tropicalis)
RHEA:23363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP
REACT:R-RNO-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Rattus norvegicus)
REACT:R-DRE-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Danio rerio)
RHEA:32391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,4R)-dihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH
RHEA:71949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-aspartate(in) + 3 Na(+)(in) => N-acetyl-L-aspartate(out) + 3 Na(+)(out)
RHEA:66133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate
REACT:R-GGA-5578883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Gallus gallus)
REACT:R-DRE-1630304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Danio rerio)
REACT:R-CEL-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Caenorhabditis elegans)
REACT:R-RNO-4568863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RAD52 with SUMO1 (Rattus norvegicus)
RHEA:26498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP
RHEA:13634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + putrescine => ADP + gamma-L-glutamylputrescine + H(+) + phosphate
REACT:R-DRE-2681667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Danio rerio)
REACT:R-HSA-8981534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin dimer:KIRREL binds FYN (Homo sapiens)
RHEA:17911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + formate => (S)-lactate
REACT:R-CFA-8938076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD38 hydrolyses NAD+ to NAM and ADP-ribose (Canis familiaris)
RHEA:60889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)
REACT:R-HSA-373741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK2 homophillic interaction (Homo sapiens)
REACT:R-DDI-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)
RHEA:62514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxymelatonin + CO2 + succinate => 2-oxoglutarate + melatonin + O2
REACT:R-DDI-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Dictyostelium discoideum)
REACT:R-XTR-114671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vWF binds to collagen (Xenopus tropicalis)
REACT:R-CFA-264976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Canis familiaris)
REACT:R-XTR-3318413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Xenopus tropicalis)
REACT:R-HSA-9684350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pp1a forms a dimer (Homo sapiens)
RHEA:59809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine => D-tyrosine
REACT:R-BTA-190408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2b (Bos taurus)
RHEA:14022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ecdysone + O2 => 20-hydroxyecdysone + A + H2O
REACT:R-HSA-9626753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 oxidizes Cys residues to form Cys-sulfenic acid (Homo sapiens)
REACT:R-DME-9734535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Drosophila melanogaster)
EC:1.3.1.120	skos:altLabel	"1-cyclohexenylcarbonyl-CoA reductase"
EC:1.3.1.120	skos:prefLabel	"cyclohexane-1-carbonyl-CoA reductase (NADP(+))"
EC:1.3.1.120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexane-1-carbonyl-CoA reductase (NADP(+))"
RHEA:43891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine <=> [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine
RHEA:23281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + cysteamine => CoA + S-acetylcysteamine
RHEA:64545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine => 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine
RHEA:57094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + glutathione + methanethiol => AH2 + S-(methylsulfanyl)glutathione
REACT:R-GGA-2022073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen triple helix formation (Gallus gallus)
REACT:R-MMU-2467794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of sister chromatids (Mus musculus)
RHEA:12561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone + UDP-alpha-D-glucose => H(+) + hydroquinone O-beta-D-glucopyranoside + UDP
REACT:R-DRE-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Danio rerio)
REACT:R-DME-209168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)
REACT:R-HSA-976801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I complex formation (Homo sapiens)
RHEA:57280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA
GO:0050497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylthioltransferase activity
GO:0050497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring alkylthio groups
GO:0050497	skos:prefLabel	"Transferring alkylthio groups"
GO:0050497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring alkylthio groups"
RHEA:13214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + succinate semialdehyde => 2 H(+) + NADPH + succinate
REACT:R-DRE-6785933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT8 transfers Gal from UDP-Gal to CERA (Danio rerio)
RHEA:37636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
EC:1.3.8.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)"
EC:1.3.8.2	skos:altLabel	"dehydrosqualene desaturase"
EC:1.3.8.2	skos:altLabel	"4,4'-diapophytoene desaturase"
EC:1.3.8.2	skos:prefLabel	"4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)"
REACT:R-DRE-159757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)
REACT:R-XTR-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Xenopus tropicalis)
RHEA:22941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginine => ADP + H(+) + N(omega)-phospho-L-arginine
RHEA:27792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-octaprenylphenol + H(+) + NADPH + O2
REACT:R-HSA-9627106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) forms dimer (Homo sapiens)
RHEA:25197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate
RHEA:25197	skos:altLabel	"5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate phosphatase"
RHEA:25197	skos:prefLabel	"5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase"
RHEA:25197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase"
GO:0000406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-strand/single-strand DNA junction binding
REACT:R-CFA-193743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
RHEA:69370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+)
RHEA:37725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine
RHEA:33427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl alpha-D-glucosaminide + L-cysteine = bacillithiol + H2O
RHEA:42565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(38/39) in tRNA => pseudouridine(38/39) in tRNA
RHEA:27924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2
REACT:R-CFA-6785213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer binds heparin (Canis familiaris)
REACT:R-DRE-9627107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP7 (Danio rerio)
REACT:R-SPO-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Schizosaccharomyces pombe)
REACT:R-BTA-2731122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2 & 4 bind VTN (Bos taurus)
RHEA:65907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + glyoxylate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine
REACT:R-DME-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Drosophila melanogaster)
RHEA:70026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(in) + Na(+)(in) <=> 4-hydroxy-L-proline(out) + Na(+)(out)
RHEA:33129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 6-phosphate + salicyl alcohol => H2O + salicin-6-phosphate
REACT:R-CFA-1306876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 activation by small molecules (Canis familiaris)
RHEA:14523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranial + H(+) + NADPH => (2E)-geraniol + NADP(+)
REACT:R-SCE-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Saccharomyces cerevisiae)
REACT:R-BTA-174445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap on the C-strand (Bos taurus)
REACT:R-XTR-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Xenopus tropicalis)
REACT:R-MMU-173542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 ubiquitinates SMAD2 (Mus musculus)
REACT:R-MMU-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)
GO:0005018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alphaPDGF receptor activity
GO:0005018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	platelet-derived growth factor alpha-receptor activity
GO:0005018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF alpha-receptor activity
REACT:R-DRE-1183128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Danio rerio)
RHEA:69315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> benzyl thiocyanate + sulfate
GO:1990883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA cytidine N-acetyltransferase activity
EC:3.2.1.120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligoxyloglucan beta-glycosidase"
EC:3.2.1.120	skos:altLabel	"isoprimeverose-producing oligoxyloglucan hydrolase"
EC:3.2.1.120	skos:prefLabel	"oligoxyloglucan beta-glycosidase"
RHEA:24963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 <=> [excited state blue fluorescent protein] + CO2
REACT:R-GGA-1234183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Gallus gallus)
GO:0150047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
GO:0150047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
REACT:R-SSC-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Sus scrofa)
RHEA:28576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + sulfate(out) => H(+)(in) + sulfate(in)
REACT:R-CEL-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Caenorhabditis elegans)
GO:0008179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylate cyclase binding
GO:0008179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Homo sapiens)
GO:0008179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl cyclase binding
REACT:R-CFA-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Canis familiaris)
REACT:R-DME-193736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)
REACT:R-GGA-1471338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 1, 4A and 103 bind CCR6 (Gallus gallus)
REACT:R-XTR-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)
REACT:R-GGA-6810464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT14 hydrolyses UDP-Glc to G1P and UMP (Gallus gallus)
REACT:R-BTA-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Bos taurus)
REACT:R-HSA-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Homo sapiens)
REACT:R-CFA-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
REACT:R-XTR-170799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Xenopus tropicalis)
RHEA:56823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cyclooctat-9-en-7-ol + O2 <=> A + cyclooctat-9-ene-5,7-diol + H2O
REACT:R-SSC-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Sus scrofa)
RHEA:50927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
RHEA:17367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + Mn(2+)(in) + phosphate => ATP + H2O + Mn(2+)(out)
RHEA:50372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphingoid base 1-phosphate(in) = an N-acylsphingoid base 1-phosphate(out)
RHEA:36003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate
RHEA:36003	skos:prefLabel	"4-hydroxy-2-oxohexanoate aldolase"
RHEA:36003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-2-oxohexanoate aldolase"
RHEA:70991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-mannopyranose(in) = H(+)(out) + L-mannopyranose(out)
REACT:R-GGA-445084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by SRC (Gallus gallus)
RHEA:48515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphinate(out) <=> ADP + H(+) + phosphate + phosphinate(in)
REACT:R-GGA-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Gallus gallus)
REACT:R-BTA-202365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
RHEA:50895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+) + hydrogen sulfide + sulfite <=> a menaquinol + thiosulfate
RHEA:43286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
REACT:R-CEL-109813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1 binds SOS1 (Caenorhabditis elegans)
REACT:R-SSC-196026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dab2 is recruited to the junctional plaques (Sus scrofa)
RHEA:19948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-DME-77613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR2 homodimer to dsRNA duplex (Drosophila melanogaster)
REACT:R-RNO-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Rattus norvegicus)
RHEA:10654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + 2 H(+) + NADH => a long-chain fatty aldehyde + H2O + NAD(+)
REACT:R-SSC-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)
RHEA:49534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylene glycol + H(+) + terephthalate => 4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O
REACT:R-RNO-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Rattus norvegicus)
RHEA:70478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + sphing-4-enine <=> 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine
RHEA:40750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysine + O2 <=> (3S)-3-hydroxy-L-lysine + CO2 + succinate
REACT:R-DME-9617996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Drosophila melanogaster)
RHEA:35071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol(in) = 4-methylphenol(out)
EC:2.4.2.1	skos:altLabel	"PNPase"
EC:2.4.2.1	skos:prefLabel	"purine-nucleoside phosphorylase"
EC:2.4.2.1	skos:altLabel	"inosine phosphorylase"
EC:2.4.2.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"purine-nucleoside phosphorylase"
REACT:R-MMU-6807118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)
RHEA:66490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quillaic acid 28-beta-D-glucoside + UDP => quillate + UDP-alpha-D-glucose
REACT:R-GGA-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Gallus gallus)
RHEA:63490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + phenanthrene-9,10-diol => 9,10-phenanthroquinone + H(+) + NADPH
REACT:R-CEL-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Caenorhabditis elegans)
RHEA:72134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine(out) <=> agmatine(in)
REACT:R-GGA-210283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and PLC gamma1 (Gallus gallus)
REACT:R-GGA-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Gallus gallus)
RHEA:34018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 <=> ergosterol + 2 H2O + NADP(+)
REACT:R-HSA-8848023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds STAP2 (Homo sapiens)
RHEA:12101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose => H2O + microthecin
REACT:R-HSA-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Homo sapiens)
RHEA:64919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate
RHEA:66761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + kainate(in) => ADP + H(+) + kainate(out) + phosphate
REACT:R-DRE-5696670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD1L is recruited to GG-NER site (Danio rerio)
REACT:R-CEL-351876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of occludin (Caenorhabditis elegans)
RHEA:33604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-hexacosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)
RHEA:72638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-1-methoxyphenazine N(5)-oxide + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine
RHEA:21363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-nicotinamide D-ribonucleotide + H(+) <=> diphosphate + NAD(+)
REACT:R-CEL-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Caenorhabditis elegans)
RHEA:58895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 <=> adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9
REACT:R-HSA-8944538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-22 microRNA binds PTEN mRNA (Homo sapiens)
REACT:R-HSA-9754180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAP translocates from extracellular region to cytosol (Homo sapiens)
RHEA:66361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O => (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)
REACT:R-DME-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Drosophila melanogaster)
GO:0102028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
RHEA:14469	skos:prefLabel	"aminomuconate-semialdehyde dehydrogenase"
RHEA:14469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminomuconate-semialdehyde dehydrogenase"
RHEA:14469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomuconate 6-semialdehyde + H2O + NAD(+) = (2Z,4E)-2-aminomuconate + 2 H(+) + NADH
GO:0016208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binding
RHEA:65841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(out) + Mg(2+)(out) + phosphate(in) => ATP(in) + Mg(2+)(in) + phosphate(out)
RHEA:34102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxynorspermidine + H(+) <=> CO2 + norspermidine
REACT:R-SPO-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Schizosaccharomyces pombe)
REACT:R-DME-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
RHEA:51495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0033288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent hydroxyectoine transmembrane transporter activity
GO:0033288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyectoine-transporting ATPase activity
GO:0033288	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxyectoine transmembrane transporter activity
GO:0033288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled hydroxyectoine transmembrane transporter activity
RHEA:51236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) = GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate
REACT:R-XTR-9756177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)
RHEA:49183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d + S-adenosyl-L-methionine <=> a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine
GO:0071443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tDNA binding
REACT:R-CFA-8940100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates VCPIP1 (Canis familiaris)
REACT:R-SPO-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Schizosaccharomyces pombe)
REACT:R-SSC-114261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-7 by the apoptosome (Sus scrofa)
REACT:R-DDI-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Dictyostelium discoideum)
REACT:R-CFA-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Canis familiaris)
REACT:R-MMU-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Mus musculus)
GO:0016896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exoribonuclease activity, producing 5' phosphomonoesters
GO:0016896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Homo sapiens)
GO:0016896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exoribonuclease activity, producing 5'-phosphomonoesters
REACT:R-DDI-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Dictyostelium discoideum)
REACT:R-HSA-9620915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTG1 gene expression is stimulated by FOXO3 (Homo sapiens)
REACT:R-DDI-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Dictyostelium discoideum)
RHEA:28735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + spermidine(out) = H(+)(out) + spermidine(in)
REACT:R-CEL-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
RHEA:69543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + streptomycin <=> 6-O-guanylylstreptomycin + diphosphate
GO:0033406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCC codon-amino acid adaptor activity
GO:0033406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine tRNA
GO:0033406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCC codon-amino acid adaptor activity
REACT:R-BTA-429415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to integrin alphaIIb beta3 (Bos taurus)
REACT:R-XTR-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Xenopus tropicalis)
REACT:R-DME-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Drosophila melanogaster)
REACT:R-SPO-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Schizosaccharomyces pombe)
REACT:R-RNO-202233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Lck by Csk (Rattus norvegicus)
REACT:R-CFA-5684875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR:ATRIP to RPA at resected DNA DSBs (Canis familiaris)
REACT:R-HSA-9021945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds GAMT gene promoter (Homo sapiens)
RHEA:35212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIDP + H2O => dIMP + H(+) + phosphate
REACT:R-CFA-877269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS-1 and SOCS-3 binds to p-JAK2 (Canis familiaris)
RHEA:53649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether A + diphosphate
REACT:R-DME-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Drosophila melanogaster)
REACT:R-SSC-209840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two DITs combine to form thyroxine (Sus scrofa)
RHEA:50585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) => 15-oxoprostaglandin E1 + H(+) + NADPH
REACT:R-DRE-1237325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A is protonated and carbamated causing release of oxygen (Danio rerio)
REACT:R-HSA-4647613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 (Homo sapiens)
REACT:R-DDI-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Dictyostelium discoideum)
RHEA:64198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + L-lysine => an N-(fatty acyl)-L-lysine + H2O
REACT:R-HSA-2060328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS1 (Homo sapiens)
RHEA:22457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + H2O => sarcosine + urea
REACT:R-BTA-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Bos taurus)
REACT:R-SSC-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Sus scrofa)
REACT:R-XTR-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)
REACT:R-PFA-5340320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTP transports GSL from plasma membrane to ER membrane (Plasmodium falciparum)
GO:0140728	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GC_rich_promoter_region binding
GO:0140728	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GC-rich region binding
GO:0140728	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GC rich promoter region binding
GO:0140728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GC-box binding
GO:0140728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GC box binding
REACT:R-HSA-937079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
RHEA:45154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoyl-CoA + methanethiol => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA
REACT:R-HSA-2569057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP3 binds TRIF to mediate necroptosis (Homo sapiens)
RHEA:61450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11a-hydroxytigecycline + H2O + NADP(+) => H(+) + NADPH + O2 + tigecycline
RHEA:64035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)
REACT:R-BTA-5691381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYSM1 deubiquitinates Histone H2A (Bos taurus)
RHEA:66006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein]
RHEA:14947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose
REACT:R-DRE-266050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to LTC4 by LTC4S (Danio rerio)
RHEA:28061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lyxopyranose <=> L-xylulose
REACT:R-XTR-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Xenopus tropicalis)
REACT:R-BTA-169719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted CD14 binds LPS (Bos taurus)
RHEA:20186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CMP-N-acyl-beta-neuraminate + H2O => an N-acylneuraminate + CMP + H(+)
RHEA:48887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + H(+) + NADPH
RHEA:41125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O
REACT:R-DRE-109291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Danio rerio)
RHEA:46654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydroepitestosterone + NADP(+) => epitestosterone + H(+) + NADPH
RHEA:37546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-chlorophenol + O2 <=> 2-amino-5-chloromuconate 6-semialdehyde
REACT:R-CFA-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Canis familiaris)
REACT:R-MMU-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Mus musculus)
GO:0042978	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-ornithine carboxy-lyase activator activity
GO:0042978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine decarboxylase activator activity
REACT:R-BTA-203130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OLR1 binds to oxidized LDL (Bos taurus)
REACT:R-RNO-187688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Rattus norvegicus)
GO:0050110	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity
GO:0050110	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-beta-N-acetyl-D-galactosaminidase activity
GO:0050110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mucinaminylserine mucinaminidase activity
GO:0050110	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-beta-N-acetylgalactosaminidase
REACT:R-GGA-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Gallus gallus)
RHEA:43077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-6805943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A1 binds TLR4:LY96 (Mus musculus)
RHEA:15216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA <=> (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA
REACT:R-RNO-8948219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3 binds Lysyl hydroxylated collagen propeptides (Rattus norvegicus)
RHEA:64764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol
GO:0008142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxysterol binding
RHEA:18343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylonate + H(+) => D-xylono-1,4-lactone + H2O
REACT:R-MMU-975122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Mus musculus)
REACT:R-HSA-5659734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:65232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydodecanoyl-CoA + H2O = 3-hydroxydodecanoate + CoA + H(+)
REACT:R-RNO-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)
REACT:R-BTA-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Bos taurus)
RHEA:15167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O2 + methylamine => H2O + O2 + sarcosine
RHEA:11045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a haloacetate + H2O => a halide anion + glycolate + H(+)
GO:0033789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylacetyl-CoA:acceptor oxidoreductase activity
GO:0033789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetyl-CoA dehydrogenase activity
GO:0033789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylacetyl-CoA:quinone oxidoreductase activity
RHEA:18766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + a sphingomyelin
REACT:R-SSC-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Sus scrofa)
REACT:R-CFA-1564120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII degradation by MMP1,2,3 (Canis familiaris)
RHEA:14775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine => 2 NADPH + palmatine + S-adenosyl-L-methionine
REACT:R-BTA-1236398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds NRGs or EGF-like ligands (Bos taurus)
RHEA:36387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl adenylate + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + H(+)
RHEA:42178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:30297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + phosphoenolpyruvate => GTP + pyruvate
REACT:R-DRE-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Danio rerio)
REACT:R-HSA-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Homo sapiens)
REACT:R-CFA-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Canis familiaris)
REACT:R-HSA-9014074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin4 (Homo sapiens)
RHEA:51484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + UDP-alpha-D-glucuronate <=> 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-DDI-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)
REACT:R-CFA-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Canis familiaris)
REACT:R-SPO-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Schizosaccharomyces pombe)
REACT:R-SSC-2404199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:IGF1R autophosphorylates (Sus scrofa)
REACT:R-RNO-211207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fragments of DFF45 dissociate from  DFF40 (Rattus norvegicus)
GO:0008685	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)
GO:0008685	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)
GO:0008685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP synthase activity
GO:0008685	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MECDP-synthase activity
GO:0008685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RHEA:63061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylorsellinate + ATP + H(+) + NADPH => 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)
REACT:R-DME-2424481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)
RHEA:12234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + glycine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+)
RHEA:41516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]
RHEA:41516	skos:prefLabel	"phylloquinone omega-hydroxylase"
RHEA:41516	skos:altLabel	"CYP4F11"
RHEA:41516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phylloquinone omega-hydroxylase"
RHEA:41516	skos:altLabel	"CYP4F2"
RHEA:41516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]
RHEA:36939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA = (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:63571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-casomorphin-7 + H2O <=> beta-casomorphin-6 + L-isoleucine
REACT:R-DDI-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Dictyostelium discoideum)
RHEA:37136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
RHEA:10273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + ATP => a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-BTA-9757578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDN (Bos taurus)
REACT:R-DRE-9707523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to BACH1:MAFK (Danio rerio)
REACT:R-DRE-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Danio rerio)
REACT:R-RNO-8964604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Rattus norvegicus)
REACT:R-BTA-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Bos taurus)
RHEA:54232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)
GO:0102954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dalcochinase activity
RHEA:35958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B <=> 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Rattus norvegicus)
REACT:R-XTR-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Xenopus tropicalis)
RHEA:37469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+)
REACT:R-BTA-1482689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)
REACT:R-CEL-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Caenorhabditis elegans)
REACT:R-BTA-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Bos taurus)
RHEA:49259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] <=> 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]
RHEA:39807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoate(in) = octadecanoate(out)
REACT:R-DRE-5682863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF168 binds DNA DSBs (Danio rerio)
REACT:R-DME-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Drosophila melanogaster)
REACT:R-BTA-264865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin A (Bos taurus)
RHEA:42951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(48) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-389026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galanin receptors can bind galanin (Xenopus tropicalis)
RHEA:41043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA
RHEA:54375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(2S,3R,9R)-pristinol + diphosphate
RHEA:67565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + chenodeoxycholate => adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)
REACT:R-MMU-9725206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds FCERI (Mus musculus)
RHEA:46901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)
REACT:R-DRE-9700121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN,MDK):PTPRZ oligomerizes (Danio rerio)
REACT:R-HSA-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)
REACT:R-BTA-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Bos taurus)
REACT:R-GGA-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Gallus gallus)
RHEA:57398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine => (S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine
REACT:R-RNO-9647999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCE1 cleaves S-Farn proRAS proteins (Rattus norvegicus)
REACT:R-BTA-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Bos taurus)
REACT:R-HSA-2467794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of sister chromatids (Homo sapiens)
REACT:R-CFA-3000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PLK1 (Canis familiaris)
REACT:R-HSA-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Homo sapiens)
REACT:R-DRE-264865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin A (Danio rerio)
REACT:R-CFA-1234183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Canis familiaris)
REACT:R-SSC-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Sus scrofa)
RHEA:11318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nitrile + H2O => an aliphatic aldoxime
REACT:R-MMU-426223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cation influx mediated by TRPC3/6/7 (Mus musculus)
RHEA:68817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => (E)-alpha-bisabolene + diphosphate
GO:0051749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAA carboxyl methyltransferase activity
GO:0051749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole acetic acid carboxyl methyltransferase activity
REACT:R-HSA-1980047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 stimulates HES1 transcription (Homo sapiens)
REACT:R-BTA-4093331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras:GTP binds p120-RasGAP (Bos taurus)
REACT:R-DME-432537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates phosphorylated CLK (Drosophila melanogaster)
REACT:R-HSA-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Homo sapiens)
REACT:R-XTR-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Xenopus tropicalis)
REACT:R-DDI-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Dictyostelium discoideum)
RHEA:40434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-SSC-8874080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates PTK2 (Sus scrofa)
REACT:R-DRE-9023633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Danio rerio)
REACT:R-HSA-1296421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 oligomerizes via NACHT domains (Homo sapiens)
REACT:R-RNO-8855915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Rattus norvegicus)
RHEA:12313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 => 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)
REACT:R-BTA-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Bos taurus)
RHEA:49321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin => (5R,6S)-5,6-epoxi-capsanthin
REACT:R-CFA-8940998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36RN, IL1F10 bind IL1RL2 (Canis familiaris)
REACT:R-DDI-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Dictyostelium discoideum)
REACT:R-PFA-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Plasmodium falciparum)
RHEA:56607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-936897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)
REACT:R-SSC-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Sus scrofa)
REACT:R-RNO-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)
RHEA:36654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-desmethylnovobiocic acid + S-adenosyl-L-methionine <=> H(+) + novobiocic acid + S-adenosyl-L-homocysteine
REACT:R-HSA-975115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)
RHEA:68898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+) => 4-hydroxybenzoate + ATP + H(+) + NADPH
REACT:R-CFA-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
RHEA:60139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate
RHEA:71043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) + L-phenylalanine(out) = L-alanine(out) + L-phenylalanine(in)
RHEA:59306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly L-luciferin
REACT:R-GGA-419002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Gallus gallus)
RHEA:53351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20a) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20a) in tRNA
REACT:R-DME-8865454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX3 (Drosophila melanogaster)
REACT:R-RNO-205289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of KIT (Rattus norvegicus)
REACT:R-RNO-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Rattus norvegicus)
REACT:R-RNO-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Rattus norvegicus)
RHEA:42551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(746) in 23S rRNA <=> pseudouridine(746) in 23S rRNA
REACT:R-DRE-4093331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras:GTP binds p120-RasGAP (Danio rerio)
REACT:R-DME-6804485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates L3MBTL2 with SUMO2 (Drosophila melanogaster)
RHEA:72414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inulobiose <=> alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O
GO:0035013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosuppressin receptor activity
REACT:R-HSA-2426566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and CLM7 (Homo sapiens)
REACT:R-CFA-5252072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AZGP1 binds PIP (Canis familiaris)
REACT:R-GGA-996727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST recruits the BHC complex (Gallus gallus)
REACT:R-XTR-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Xenopus tropicalis)
RHEA:53105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + S-adenosyl-L-methionine => 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine
RHEA:53381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(16) in tRNA + NAD(+) => H(+) + NADH + uridine(16) in tRNA
REACT:R-XTR-193668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR and RHOA-GDI interact (Xenopus tropicalis)
RHEA:13679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate => D-ribulose 5-phosphate
REACT:R-CEL-390641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA1A,B,D bind ADR,NAd (Caenorhabditis elegans)
RHEA:65319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chrodrimanin H + O2 <=> chrodrimanin E + CO2 + H2O + succinate
GO:0052621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diguanylate cyclase activity
GO:0052621	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GTP:GTP guanylyltransferase activity
RHEA:15207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+) => a dolichyl diphosphooligosaccharide + H2O
RHEA:10853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + leachianone G => diphosphate + sophoraflavanone G
EC:3.4.21.117	skos:altLabel	"serine protease 6"
EC:3.4.21.117	skos:prefLabel	"stratum corneum chymotryptic enzyme"
EC:3.4.21.117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stratum corneum chymotryptic enzyme"
EC:3.4.21.117	skos:altLabel	"SCCE"
EC:3.4.21.117	skos:altLabel	"kallikrein 7"
RHEA:51821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + decanoate(out) + H(+)(out) => AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)
RHEA:13638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methane + NADH + O2 => H2O + methanol + NAD(+)
RHEA:49260	skos:prefLabel	"protein-N(pi)-phosphohistidine--D-galactose phosphotransferase"
RHEA:49260	skos:altLabel	"D-galactose PTS permease"
RHEA:49260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] = D-galactose 6-phosphate(in) + L-histidyl-[protein]
RHEA:49260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--D-galactose phosphotransferase"
REACT:R-RNO-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Rattus norvegicus)
RHEA:46844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-BTA-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Bos taurus)
REACT:R-DRE-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Danio rerio)
RHEA:20386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + H(+) + NADH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)
REACT:R-GGA-5691006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Gallus gallus)
REACT:R-XTR-3134800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING dimerization (Xenopus tropicalis)
REACT:R-GGA-9629918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 translocates to the nucleus (Gallus gallus)
REACT:R-HSA-6797763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 inhibits BIRC5 expression (Homo sapiens)
RHEA:52039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate <=> L-isoleucine + tuberonate
RHEA:33835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexacosanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexacosanoate
REACT:R-XTR-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Xenopus tropicalis)
REACT:R-XTR-2980720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 binds NEK6/NEK7 in the cytosol (Xenopus tropicalis)
REACT:R-XTR-2396370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds collagens II, III and V (Xenopus tropicalis)
REACT:R-XTR-1236965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Export of peptide loaded MHC class I complex to PM (Xenopus tropicalis)
REACT:R-XTR-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Xenopus tropicalis)
RHEA:22045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+)(in) + H2O + K(+)(out) => ADP + 2 H(+)(out) + K(+)(in) + phosphate
REACT:R-CFA-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Canis familiaris)
REACT:R-MMU-5684875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR:ATRIP to RPA at resected DNA DSBs (Mus musculus)
REACT:R-HSA-420243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHRH receptor binds GHRH (Homo sapiens)
RHEA:12698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dGMP => ADP + dGDP
GO:0102643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scalarane-17alpha-19-diol synthase activity
REACT:R-SSC-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Sus scrofa)
REACT:R-GGA-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Gallus gallus)
RHEA:15414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate => H2O + oxaloacetate
RHEA:55179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + butanoyl-CoA + O2 <=> 2-hydroxybutanoyl-CoA + CO2 + succinate
REACT:R-SPO-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)
RHEA:69796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartyl-tRNA(Asp) + H2O => D-aspartate + H(+) + tRNA(Asp)
REACT:R-GGA-9014456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOG (Gallus gallus)
REACT:R-MMU-5610758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Mus musculus)
RHEA:52273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine => gramine + H(+) + S-adenosyl-L-homocysteine
RHEA:25344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamate + NH4(+) => H2O + urea
REACT:R-HSA-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Homo sapiens)
REACT:R-SSC-8871265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD4 (Sus scrofa)
REACT:R-HSA-5685201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCDC59:TTF1 binds SFTPC gene (Homo sapiens)
RHEA:68951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esculetin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + scopoletin
REACT:R-BTA-5632668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMO translocates to the cilium (Bos taurus)
REACT:R-RNO-1306965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Rattus norvegicus)
REACT:R-MMU-1977958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with ERBB3 (Mus musculus)
REACT:R-BTA-8944242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVII (Bos taurus)
RHEA:49989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + H(+) + NADPH + O2 => H2O + methyl acetate + NADP(+)
REACT:R-CFA-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Canis familiaris)
RHEA:56618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,4-trichlorobenzene + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene
REACT:R-MMU-8871366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Mus musculus)
REACT:R-BTA-170026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protons are translocated from the intermembrane space to the matrix (Bos taurus)
REACT:R-MMU-6809720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM1:MTMR12 (Mus musculus)
GO:1990984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA demethylase activity
REACT:R-RNO-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Rattus norvegicus)
RHEA:67594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+) => a 5'-end CoA-ribonucleoside in mRNA + H2O
RHEA:30075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H2O = cytosine + D-ribose 5-phosphate
RHEA:49101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester
REACT:R-SPO-1482545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)
GO:0070290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0070290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl-phosphatidylethanolamine-specific phospholipase D activity
GO:0070290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A2PE hydrolyses to A2E (Homo sapiens)
GO:0070290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPE-specific phospholipase D activity
RHEA:23408	skos:prefLabel	"precorrin-6A reductase"
RHEA:23408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + precorrin-6B = 2 H(+) + NADPH + precorrin-6A
RHEA:23408	skos:altLabel	"precorrin-6Y:NADP(+) oxidoreductase"
RHEA:23408	skos:altLabel	"precorrin-6X reductase"
RHEA:23408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"precorrin-6A reductase"
REACT:R-BTA-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Bos taurus)
REACT:R-CEL-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Caenorhabditis elegans)
RHEA:67645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dZDP => ADP + dZTP
REACT:R-BTA-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Bos taurus)
REACT:R-GGA-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Gallus gallus)
RHEA:71848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate(out) => glycoursodeoxycholate(in)
REACT:R-CFA-913371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF receptor alpha:GM-CSF binds Bc (Canis familiaris)
RHEA:55443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-2002440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen C-propeptides (Mus musculus)
RHEA:72133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine(in) => agmatine(out)
RHEA:38133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol
REACT:R-DRE-352182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Danio rerio)
REACT:R-DDI-9749986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Dictyostelium discoideum)
REACT:R-SCE-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Saccharomyces cerevisiae)
RHEA:52405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-O-phospho-L-erythronate + H(+) => CO2 + dihydroxyacetone phosphate
REACT:R-HSA-8950260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Proteasome activator complex subunit 2 (Homo sapiens)
REACT:R-CEL-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Caenorhabditis elegans)
RHEA:59260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-SSC-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Sus scrofa)
REACT:R-HSA-373751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC-5 binds Netrin-1 (Homo sapiens)
RHEA:42733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(527) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:42741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:70225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-glutamate => (2S)-2-aminobutanoate + 2-oxoglutarate
REACT:R-BTA-5637686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Bos taurus)
REACT:R-DME-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)
RHEA:24690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"eugenol synthase"
RHEA:24690	skos:prefLabel	"eugenol synthase"
RHEA:24690	skos:altLabel	"EGS2"
RHEA:24690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + eugenol + NADP(+) = (E)-coniferyl acetate + NADPH
RHEA:24690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + eugenol + NADP(+) = a coniferyl ester + NADPH
REACT:R-BTA-5672948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK3 phosphorylates KSR1 (Bos taurus)
REACT:R-DDI-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Dictyostelium discoideum)
REACT:R-RNO-177927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to EGF:EGFR:GRB2:GAB1 (Rattus norvegicus)
REACT:R-MMU-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)
REACT:R-MMU-5617138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)
REACT:R-BTA-1470009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs (Bos taurus)
RHEA:17778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)
REACT:R-DRE-71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Danio rerio)
REACT:R-DME-372529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of acetylcholine at the synapse (Drosophila melanogaster)
GO:0051428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide hormone receptor binding
GO:0051428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polypeptide hormone receptor binding
REACT:R-XTR-211874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2S1 4-hydroxylates atRA (Xenopus tropicalis)
REACT:R-MMU-9688838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds STUB1 (Mus musculus)
RHEA:23865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol 2-phosphate => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP
REACT:R-DRE-176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST trimers transfer GS from GSH to luminal substrates (Danio rerio)
RHEA:63121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenamide + H2O => (11Z)-eicosenoate + NH4(+)
REACT:R-HSA-9024766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Homo sapiens)
REACT:R-SSC-1861595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extension of pseudopodia by myosin-X in a PI3K dependent manner (Sus scrofa)
RHEA:28047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + propanoyl-CoA => CoA + propanoyl phosphate
REACT:R-SSC-2160874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses (HA)50 (Sus scrofa)
REACT:R-DDI-877187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates loss of intracellular K+ (Dictyostelium discoideum)
GO:0018810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity
RHEA:16176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + dopamine <=> (S)-norcoclaurine + H2O
REACT:R-MMU-9649963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC3 channel blockers bind ASIC3 trimer (Mus musculus)
REACT:R-MMU-77342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Mus musculus)
RHEA:55824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1),7(1)-dihydroxybacteriochlorophyllide d = a bacteriochlorophyllide f + H2O
RHEA:70738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + glycine betaine(out) + 2 Na(+)(out) <=> chloride(in) + glycine betaine(in) + 2 Na(+)(in)
RHEA:72215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)
RHEA:43394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O
REACT:R-SSC-5694077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Sus scrofa)
RHEA:32752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline(out) => choline(in)
REACT:R-GGA-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Gallus gallus)
REACT:R-SSC-187934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Sus scrofa)
RHEA:26074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucuronate => D-glucuronate + H(+) + UDP
REACT:R-HSA-5246506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botC HC:LC binds GT1b on the target cell surface (Homo sapiens)
GO:0015265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea channel activity
GO:0052812	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 5-phosphotransferase activity
GO:0052812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,4-bisphosphate 5-kinase activity
REACT:R-RNO-4167509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial BTD hydrolyses BCTN (Rattus norvegicus)
REACT:R-SPO-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Schizosaccharomyces pombe)
REACT:R-DRE-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Danio rerio)
REACT:R-RNO-6788385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of ATR and ATRIP is recruited to ICL-DNA (Rattus norvegicus)
REACT:R-SSC-2424487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)
GO:0001567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol 25-hydroxylase activity
GO:0001567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity
GO:0001567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol 25-monooxygenase activity
REACT:R-BTA-212432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DRIP coactivator complex (Bos taurus)
REACT:R-DRE-5218804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK activation by VEGFR (Danio rerio)
REACT:R-HSA-2534248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP2, MMP3, MMP7 (Homo sapiens)
REACT:R-DRE-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Danio rerio)
REACT:R-SSC-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Sus scrofa)
REACT:R-XTR-1236964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of peptide bound MHC class I complex to cell surface (Xenopus tropicalis)
RHEA:47286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:32334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-endo-fenchol + NAD(+) <=> (1S,4R)-fenchone + H(+) + NADH
RHEA:52407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-O-phospho-L-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate
RHEA:50851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
REACT:R-XTR-8853405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 binds AURKA at centrosomes (Xenopus tropicalis)
RHEA:47082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5beta-estran-3-one + NADP(+) => 17beta-hydroxyestr-4-en-3-one + H(+) + NADPH
RHEA:62359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GDP + H2O <=> 8-oxo-GMP + H(+) + phosphate
RHEA:54120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine h + O2 = coelenterazine h dioxetanone
REACT:R-HSA-2243926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of histidino-hydroxylysinonorleucine cross-links (Homo sapiens)
REACT:R-MMU-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Mus musculus)
REACT:R-RNO-5649705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Rattus norvegicus)
RHEA:44734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + glycerol + H(+) => 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O
RHEA:63739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + H(+) + NADPH <=> 2-phenylethanol + NADP(+)
REACT:R-HSA-1604741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP14 (MT1-MMP) (Homo sapiens)
RHEA:52756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate
REACT:R-CFA-83793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Canis familiaris)
REACT:R-XTR-380278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Xenopus tropicalis)
REACT:R-DME-8949661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Drosophila melanogaster)
REACT:R-CEL-4085331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-1 SUMOylates PARK7 with SUMO1 (Caenorhabditis elegans)
REACT:R-CEL-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Caenorhabditis elegans)
RHEA:37829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorophenol + CO2 + pyruvate + succinate => (S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2
GO:0009042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-oxoisovalerate aminotransferase activity
GO:0009042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine--pyruvate aminotransferase activity
GO:0009042	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transaminase C activity
GO:0009042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine--valine transaminase activity
GO:0009042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine-pyruvate transaminase activity
GO:0009042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine-pyruvate aminotransferase activity
GO:0009042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-valine:pyruvate aminotransferase activity
RHEA:49935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-octadienoyl-CoA <=> (2E,5Z)-octadienoyl-CoA
RHEA:62755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pravastatin lactone <=> (S)-2-methylbutanoate + H(+) + pravastatin diol lactone
REACT:R-DDI-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Dictyostelium discoideum)
REACT:R-XTR-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Xenopus tropicalis)
REACT:R-MMU-166387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The FA anion diffuses away laterally from UCP (Mus musculus)
REACT:R-GGA-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Gallus gallus)
REACT:R-MMU-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Mus musculus)
REACT:R-HSA-8935731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
REACT:R-BTA-5578783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Bos taurus)
RHEA:63399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + Fe(II)-heme i + H2O <=> AH2 + Fe(II)-hydroxyheme i
RHEA:47176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O
REACT:R-HSA-167686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLCG1 hydrolyses PIP2 (Homo sapiens)
RHEA:55263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-BTA-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Bos taurus)
RHEA:60162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + vincristine(out) => ATP + H2O + vincristine(in)
REACT:R-DRE-201631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 3 (Danio rerio)
RHEA:66106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-kynurenine
RHEA:46930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol
RHEA:46431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]
RHEA:16731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + H(+) + NADPH => (1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+)
RHEA:69080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) = 3,4-dihydroxyphenylacetate + 2 H(+) + NADH
RHEA:59909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanal + NADP(+) => 2 H(+) + hexanoate + NADPH
REACT:R-CFA-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Canis familiaris)
REACT:R-GGA-5655466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Gallus gallus)
RHEA:27403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate => 2-hydroxychromene-2-carboxylate
RHEA:36494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA
RHEA:30639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)
RHEA:30639	skos:prefLabel	"mannosylglycerate synthase"
RHEA:30639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosylglycerate synthase"
RHEA:61116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-383373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 3 (NK3) binds to neurokinin B (Rattus norvegicus)
REACT:R-DRE-8941628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)
REACT:R-SPO-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Schizosaccharomyces pombe)
REACT:R-CFA-8984023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Canis familiaris)
REACT:R-DRE-114254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS binds to APAF1 (Danio rerio)
RHEA:68536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate
RHEA:16855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + fumarate => N(6)-(1,2-dicarboxyethyl)-AMP
RHEA:23669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin => AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]
RHEA:42266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + octanoyl-CoA
GO:0103061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-methoxy-C60-meroacyl-AMP ligase activity
REACT:R-CFA-9698170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)
REACT:R-SSC-8954110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1:EPC1 binds the PRC2 complex (Sus scrofa)
RHEA:68774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + germacrene C => (2Z,6Z)-farnesyl diphosphate
RHEA:53718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + UDP-N-acetyl-alpha-D-muramate => H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP
REACT:R-HSA-1484099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)
RHEA:19055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O
REACT:R-BTA-433101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Bos taurus)
REACT:R-PFA-72095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internal Methylation of mRNA (Plasmodium falciparum)
RHEA:50207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate
REACT:R-RNO-6785648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEMO1 binds RHOA:GTP:DIAPH1 (Rattus norvegicus)
REACT:R-DME-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Drosophila melanogaster)
REACT:R-XTR-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Xenopus tropicalis)
RHEA:41539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Danio rerio)
RHEA:16721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylenetetrahydromethanopterin dehydrogenase"
RHEA:16721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:16721	skos:altLabel	"N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase"
RHEA:16721	skos:altLabel	"5,10-methylenetetrahydromethanopterin dehydrogenase"
RHEA:16721	skos:prefLabel	"methylenetetrahydromethanopterin dehydrogenase"
GO:0140704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',2'-cyclic GMP-AMP binding
GO:0140704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',2' cyclic-GMP-AMP binding
GO:0140704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',2'-cGAMP binding
GO:0140704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',2'-cyclic GAMP binding
REACT:R-RNO-5638141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)
RHEA:29795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + H2O(in) + Zn(2+)(out) = ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)
RHEA:29795	skos:altLabel	"Zn(2+)-transporting ATPase"
RHEA:29795	skos:altLabel	"Zn(2+) ABC transporter"
RHEA:29795	skos:prefLabel	"ABC-type Zn(2+) transporter"
RHEA:29795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type Zn(2+) transporter"
RHEA:47703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ketocytochalasin + NADPH + O2 <=> H2O + iso-precytochalasin + NADP(+)
RHEA:58141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-AMP + cytidine(34) in elongator tRNA(Met) => AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)
REACT:R-GGA-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Gallus gallus)
RHEA:31265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	but-3-yn-1-ol + pyrroloquinoline quinone => but-3-ynal + H(+) + pyrroloquinoline quinol
REACT:R-CFA-193696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Canis familiaris)
REACT:R-HSA-6788385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)
GO:0102789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity
GO:0050609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphonate dehydrogenase activity
GO:0050609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD:phosphite oxidoreductase activity
GO:0050609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphite dehydrogenase activity
GO:0050609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphonate:NAD+ oxidoreductase activity
GO:0050609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent phosphite dehydrogenas activity
RHEA:71101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in) => androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out)
RHEA:19887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine + H(+) + H2O2 => (S)-reticuline + O2
RHEA:30390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + GDP + H(+)
REACT:R-BTA-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Bos taurus)
RHEA:35649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP + 2 diphosphate => ATP + GTP
REACT:R-DRE-5628871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 promotes EP300-mediated acetylation of TP53 (Danio rerio)
REACT:R-CFA-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
RHEA:10231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> cis-aconitate + H2O
RHEA:32975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine
REACT:R-SSC-140851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Sus scrofa)
REACT:R-BTA-3134946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 ubiquitination by TRIM21 (Bos taurus)
RHEA:31858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> achilleol B
REACT:R-RNO-3000335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Rattus norvegicus)
REACT:R-RNO-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Rattus norvegicus)
REACT:R-RNO-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Rattus norvegicus)
REACT:R-HSA-111237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR1 homodimer (Homo sapiens)
RHEA:58469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate
REACT:R-PFA-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-XTR-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Xenopus tropicalis)
REACT:R-MMU-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Mus musculus)
RHEA:72451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) = a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)
REACT:R-SSC-443978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR11 binds CCL19, CCL21 & CCL25 (Sus scrofa)
REACT:R-CEL-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Caenorhabditis elegans)
REACT:R-SCE-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Saccharomyces cerevisiae)
GO:0035174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-serine kinase activity
GO:0035174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serine kinase activity
REACT:R-XTR-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Xenopus tropicalis)
RHEA:18224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate
GO:0062131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-butenylglucosinolate 2-hydroxylase activity
GO:0062131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	But-3-enyl Glucosinolate-2-hydroxylase activity
RHEA:16039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-alpha-D-ribose 1-phosphate + thymine => phosphate + thymidine
REACT:R-RNO-2465924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1LW binds 11cRAL (Rattus norvegicus)
RHEA:33482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + lanosterol <=> CoA + lanosteryl ester
REACT:R-MMU-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Mus musculus)
REACT:R-SSC-188002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rab5-mediated recruitment of class III PI3K to TLR9 (Sus scrofa)
REACT:R-SSC-158419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Sus scrofa)
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formic dehydrogenase activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	chi-ADH activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GS-FDH activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD- and glutathione-dependent formaldehyde dehydrogenase activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(hydroxymethyl)glutathione dehydrogenase activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent formaldehyde dehydrogenase activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	class III alcohol dehydrogenase activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked formaldehyde dehydrogenase activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GD-FALDH activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione-dependent formaldehyde dehydrogenase activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FDH activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity
GO:0051903	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ADH3 activity
REACT:R-RNO-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Rattus norvegicus)
RHEA:65355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O
REACT:R-DME-2028555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Drosophila melanogaster)
REACT:R-DME-174235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdc20 (Drosophila melanogaster)
RHEA:65734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + heptanal + succinate + sulfate => 2-oxoglutarate + heptyl sulfate + O2
REACT:R-BTA-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Bos taurus)
RHEA:20924	skos:prefLabel	"peptidylamidoglycolate lyase"
RHEA:20924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [peptide]-C-terminal (2S)-2-hydroxyglycine = a [peptide]-C-terminal amide + glyoxylate
RHEA:20924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidylamidoglycolate lyase"
RHEA:20924	skos:altLabel	"alpha-hydroxyglycine amidating dealkylase"
REACT:R-HSA-5651685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC34A1 does not cotransport Pi, 3Na+ (Homo sapiens)
REACT:R-CEL-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Caenorhabditis elegans)
REACT:R-HSA-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Homo sapiens)
RHEA:19883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein] => GTP + L-lysyl-[protein]
REACT:R-MMU-9648983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Mus musculus)
REACT:R-HSA-6804402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F1 (Homo sapiens)
REACT:R-XTR-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)
REACT:R-DRE-8943041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Danio rerio)
REACT:R-GGA-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Gallus gallus)
REACT:R-HSA-8868344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5:p25 phosphorylates lamin A (Homo sapiens)
REACT:R-MMU-9748996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers cleave AZA to 6MP (Mus musculus)
REACT:R-CFA-264758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Canis familiaris)
REACT:R-DME-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Drosophila melanogaster)
RHEA:53687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
REACT:R-CFA-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Canis familiaris)
RHEA:70431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + Li(+)(in) = 2 H(+)(in) + Li(+)(out)
RHEA:21707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tyrosine <=> NH4(+) + phenol + pyruvate
RHEA:31114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + butanoyl-CoA <=> 3-oxohexanoyl-CoA + CoA
REACT:R-HSA-354087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2 to p-PTK2 (Homo sapiens)
REACT:R-XTR-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Xenopus tropicalis)
REACT:R-CFA-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Canis familiaris)
RHEA:71364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) => 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)
RHEA:64291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] <=> cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:30003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
REACT:R-CFA-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)
REACT:R-CFA-5696960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP49 deubiquitinates H2B (Canis familiaris)
REACT:R-MMU-6800490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates PIDD1 (Mus musculus)
REACT:R-MMU-4085217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Mus musculus)
REACT:R-RNO-419490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATP to P2X receptors (Rattus norvegicus)
REACT:R-SSC-8848436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CDKN1B (Sus scrofa)
GO:0016491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown sepiapterin synthase transforms PTHP to sepiapterin (Homo sapiens)
GO:0016491	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on other substrates
GO:0016491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	redox activity
GO:0016491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity
REACT:R-CEL-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)
REACT:R-GGA-1006143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C3b (Gallus gallus)
RHEA:68828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	borneol + NAD(+) = camphor + H(+) + NADH
GO:0106265	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyketide syntase
GO:0106265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA
GO:0106265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THPH synthase activity
REACT:R-HSA-9701556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RG gene expression downstream of ALK signaling (Homo sapiens)
REACT:R-CFA-9650165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers bind H+ (Canis familiaris)
REACT:R-MMU-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Mus musculus)
GO:0102826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol-3-glucoside-glucosyltransferase activity
REACT:R-SPO-1483063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG and CDP-DAG are converted to CL by CRLS1 (Schizosaccharomyces pombe)
RHEA:41341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoate + O2 => 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate
REACT:R-DRE-2090038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses heparan chain(2) (Danio rerio)
REACT:R-MMU-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Mus musculus)
REACT:R-RNO-975119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Rattus norvegicus)
REACT:R-XTR-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Xenopus tropicalis)
RHEA:59865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoate + ATP + L-glutamine => (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)
RHEA:40963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O
RHEA:40963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"o-aminophenol oxidase"
RHEA:40963	skos:prefLabel	"o-aminophenol oxidase"
RHEA:40963	skos:altLabel	"isophenoxazine synthase"
REACT:R-HSA-3662344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HEXB does not cleave the terminal GalNAc from DS (Homo sapiens)
RHEA:18697	skos:altLabel	"4-hydroxyphenylpyruvate carboxy-lyase"
RHEA:18697	skos:prefLabel	"4-hydroxyphenylpyruvate decarboxylase"
RHEA:18697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylpyruvate decarboxylase"
RHEA:18697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO2
RHEA:64128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-L-phenylalanine = L-phenylalanine + octadecanoate
RHEA:71555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-C(alpha)-glycyl-dTMP in DNA + H(+) = 5-aminoethyl-dUMP in DNA + CO2
REACT:R-GGA-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Gallus gallus)
RHEA:64886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP
REACT:R-BTA-2213248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of antigen loaded MHC II molecules to surface (Bos taurus)
REACT:R-HSA-9763200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA2 mutants do not bind SEM1 (DSS1) (Homo sapiens)
REACT:R-RNO-392053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS binds Grb2 bound to pFAK:NCAM1 (Rattus norvegicus)
RHEA:55181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylnonanoyl-CoA + O2 => 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate
REACT:R-RNO-450173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)
RHEA:35173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + novobiocin(out) => H(+)(out) + novobiocin(in)
RHEA:28848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Li(+)(in) + melibiose(in) => Li(+)(out) + melibiose(out)
GO:0097256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenyllactate dehydrogenase activity
GO:0097256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH
GO:0005251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delayed rectifier potassium channel activity
GO:0140855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H3-S57 specific)
GO:0140855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3S57 kinase activity
GO:0140855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serine kinase activity (H3-S57 specific)
GO:0140855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-serine kinase activity (H3-S57 specific)
RHEA:72146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + GTP + S-adenosyl-L-methionine <=> 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine
GO:0072555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-beta-ketosteroid reductase activity
GO:0072555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-ketosteroid reductase activity
GO:0072555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-beta-ketosteroid reductase (NADPH) activity
REACT:R-SCE-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Saccharomyces cerevisiae)
RHEA:59860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP
RHEA:31272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + naphthalene-1,2-diol
REACT:R-SSC-5661114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Sus scrofa)
REACT:R-BTA-3451153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits TRRAP/KAT5 HAT components (Bos taurus)
RHEA:65217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-CoA + H2O => 3-oxododecanoate + CoA + H(+)
REACT:R-DME-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Drosophila melanogaster)
REACT:R-DRE-8953946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Danio rerio)
GO:0062066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSII associated light-harvesting complex II binding
REACT:R-DME-8964333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Drosophila melanogaster)
RHEA:47584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GT1c (d18:1(4E)) + H(+) + UDP
RHEA:58035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9007496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
REACT:R-DRE-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Danio rerio)
RHEA:39029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose
RHEA:10467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O <=> n acetate + chitosan
REACT:R-SSC-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)
EC:3.1.3.52	skos:altLabel	"branched-chain oxo-acid dehydrogenase phosphatase"
EC:3.1.3.52	skos:prefLabel	"[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase"
EC:3.1.3.52	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase"
RHEA:71348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-lysine(out) + 2 Na(+)(out) => chloride(in) + L-lysine(in) + 2 Na(+)(in)
REACT:R-MMU-3371353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble TNF-α binds TNFR1 (Mus musculus)
RHEA:43930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	progesterone => pregn-5-ene-3,20-dione
REACT:R-SSC-162729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Sus scrofa)
REACT:R-HSA-182279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
RHEA:51131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + an aliphatic amine + H2O <=> AH2 + an aldehyde + NH4(+)
RHEA:49985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + jasmonate + NADPH + O2 => (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)
REACT:R-SSC-8869580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEK binds TFAP2A homodimers (Sus scrofa)
EC:3.4.19.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"desampylase"
EC:3.4.19.15	skos:altLabel	"SAMP-protein conjugate cleaving protease"
EC:3.4.19.15	skos:prefLabel	"desampylase"
REACT:R-HSA-9760097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2 and MAFK bind the GSTA1 gene (Homo sapiens)
REACT:R-MMU-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Mus musculus)
GO:0086083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
RHEA:16419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-glutamate + NADH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+)
GO:0034885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-N-formylaminovinylacetate hydrolase activity
RHEA:59787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH
REACT:R-MMU-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Mus musculus)
REACT:R-SSC-193743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
REACT:R-HSA-9665524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP translocates from cytosol to extracellular space (stimuated by C3AR1:C3a) (Homo sapiens)
REACT:R-RNO-5654620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
RHEA:32101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + TRIBOA beta-D-glucoside
REACT:R-DRE-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Danio rerio)
REACT:R-HSA-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Homo sapiens)
REACT:R-MMU-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Mus musculus)
REACT:R-MMU-444498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin-releasing hormone receptor binds thyrotropin (Mus musculus)
RHEA:60437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutyl acetate + H2O => 3-methylbutanol + acetate + H(+)
RHEA:37477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:45119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-ipsdienol + NADP(+) <=> H(+) + ipsdienone + NADPH
REACT:R-MMU-5357860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Mus musculus)
RHEA:43826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:11456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"
RHEA:11456	skos:altLabel	"uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase"
RHEA:11456	skos:altLabel	"N-acetylglucosaminyltransferase I"
RHEA:11456	skos:altLabel	"alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase"
RHEA:11456	skos:prefLabel	"alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"
RHEA:11456	skos:altLabel	"N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I"
RHEA:11456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:11456	skos:altLabel	"GlcNAc-T I"
RHEA:11456	skos:altLabel	"GnTI"
REACT:R-RNO-5624129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LZTFL1 binds the BBSome and prevents its traffic to the cilium (Rattus norvegicus)
REACT:R-CFA-2243931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-lysinonorleucine cross-links (Canis familiaris)
RHEA:55625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O => 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)
RHEA:50258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SPO-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Schizosaccharomyces pombe)
REACT:R-HSA-2160851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAS1,2,3 mediate the polymerisation of HA (Homo sapiens)
RHEA:46913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juvenile hormone III => H(+) + juvenile hormone III carboxylate + methanol
REACT:R-HSA-211651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of PAK-2 at 212 (Homo sapiens)
GO:0106282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
GO:0106282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH
RHEA:19141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol = 11-cis-retinol
GO:0008425	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ubiquinone biosynthetic process methyltransferase activity
GO:0008425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme Q biosynthetic process methyltransferase activity
GO:0008425	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ubiquinone biosynthesis methyltransferase activity
GO:0008425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme Q biosynthesis methyltransferase activity
GO:0008425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity
GO:0008425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
REACT:R-MMU-429815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation Of Bloc-1 Complex (Mus musculus)
RHEA:60209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 => 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate
REACT:R-DRE-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Danio rerio)
REACT:R-BTA-1676162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Bos taurus)
GO:0008459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin 6-sulphotransferase activity
GO:0008459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	terminal 6-sulfotransferase activity
GO:0008459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity
GO:0008459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CHST3 does not transfer SO4(2-) to chondroitin (Homo sapiens)
GO:0008459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin 6-O-sulfotransferase activity
GO:0008459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity
GO:0008459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin 6-sulfotransferase activity
RHEA:33400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) => L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)
REACT:R-DRE-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Danio rerio)
REACT:R-HSA-380455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CDK11p58 to the centrosomes (Homo sapiens)
REACT:R-SSC-2509816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses IDP to IMP (Sus scrofa)
REACT:R-DRE-2395320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 binds integrins (Danio rerio)
REACT:R-DRE-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Danio rerio)
RHEA:15935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + H(+) + NADH => (S)-propane-1,2-diol + NAD(+)
RHEA:41317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-SSC-3697894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN2 (Sus scrofa)
RHEA:11054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminophenol + CO2 + H2O + NAD(+) => 4-aminobenzoate + 2 H(+) + NADH + O2
RHEA:35564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-hexadecenoyl) ethanolamine => (9Z)-hexadecenoate + ethanolamine
REACT:R-SSC-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Sus scrofa)
GO:0016877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase activity, forming carbon-sulphur bonds
GO:0016877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase activity, forming carbon-sulfur bonds
GO:0016877	skos:prefLabel	"Forming carbon-sulfur bonds"
GO:0016877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming carbon-sulfur bonds"
REACT:R-DRE-5340251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Danio rerio)
REACT:R-HSA-417843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y13 binds ADP (Homo sapiens)
REACT:R-HSA-8941234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Homo sapiens)
REACT:R-CEL-5340214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB binds O2 (Caenorhabditis elegans)
REACT:R-BTA-2990880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6/NEK7 phosphorylates NUP98 (Bos taurus)
RHEA:24977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Rattus norvegicus)
REACT:R-GGA-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Gallus gallus)
REACT:R-SSC-141422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 converted  to an inhibitory state via interaction with Mad1 (Sus scrofa)
RHEA:30792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + pyruvate => dGDP + H(+) + phosphoenolpyruvate
REACT:R-CFA-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Canis familiaris)
REACT:R-XTR-77338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Xenopus tropicalis)
RHEA:65579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate <=> an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP
RHEA:18971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain alkane + CO2 => a long-chain fatty acid + H(+) + hnu
RHEA:69814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-3640872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
RHEA:39510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)
RHEA:68304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] = 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-5578883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Canis familiaris)
REACT:R-DME-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Drosophila melanogaster)
REACT:R-SSC-111742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)
REACT:R-BTA-76054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Bos taurus)
REACT:R-MMU-202331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to SLP-76 (Mus musculus)
REACT:R-SCE-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Saccharomyces cerevisiae)
RHEA:20752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 2 cob(II)alamin + 2 H(+) + 2 H2O = AH2 + 2 aquacob(III)alamin
REACT:R-HSA-2672302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated LEPR Binds SOCS3 (Homo sapiens)
RHEA:21435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NAD(+) <=> H(+) + NADH + oxaloacetate
REACT:R-MMU-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Mus musculus)
REACT:R-HSA-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Homo sapiens)
GO:0047228	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:diacylglycerol glucosyltransferase activity
GO:0047228	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:1,2-diacylglycerol glucosyltransferase activity
GO:0047228	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity
GO:0047228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacylglycerol 3-glucosyltransferase activity
GO:0047228	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-diacylglycerol glucosyltransferase activity
GO:0047228	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity
GO:0047228	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-diacylglycerol glucosyltransferase activity
REACT:R-SCE-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Saccharomyces cerevisiae)
REACT:R-HSA-3785684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by CTSG (Homo sapiens)
RHEA:17642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine => agmatine + CO2
RHEA:47155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate + H2O + NAD(+) <=> 2-oxoglutarate + 2 H(+) + NADH
RHEA:25244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + H2O <=> (S)-ureidoglycolate + NH4(+)
REACT:R-CFA-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Canis familiaris)
RHEA:40901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-SCE-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Saccharomyces cerevisiae)
RHEA:37316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamine + H2O => glycine + L-glutamine
REACT:R-HSA-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)
REACT:R-XTR-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Xenopus tropicalis)
REACT:R-CFA-5624952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the retrograde IFT train (Canis familiaris)
REACT:R-SSC-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Sus scrofa)
RHEA:51658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-fructuronate => keto-D-tagaturonate
RHEA:17844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP
GO:0106316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite reductase NADH activity
GO:0106316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 3 NAD(+) + NH4(+) = 5 H(+) + 3 NADH + nitrite
REACT:R-CEL-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
REACT:R-SSC-141159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-mediated dimerization of procaspase-8 (Sus scrofa)
REACT:R-XTR-1168445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B binds the GH receptor complex (Xenopus tropicalis)
REACT:R-DRE-1011600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rabenosyn-5 connects  Rab5 to VPS-45 (Danio rerio)
REACT:R-SSC-5668984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 or PAK2 phosphorylates MYLK (Sus scrofa)
RHEA:29161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a menaquinol(in) + 2 H(+)(out) + nitrite(out)
REACT:R-HSA-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Homo sapiens)
REACT:R-DRE-6797568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind CASK:Protein 4.1 (Danio rerio)
RHEA:46006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + H(+) + NADH => 2-methylpropanal + CoA + NAD(+)
GO:0090524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome-b5 reductase activity, acting on NADH
GO:0090524	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytochrome b5 reductase activity
REACT:R-PFA-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-HSA-9694367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylated M localizes to the Golgi membrane (Homo sapiens)
REACT:R-CEL-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Caenorhabditis elegans)
RHEA:54121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine h + O2 => coelenterazine h dioxetanone
REACT:R-SSC-9029566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Sus scrofa)
RHEA:30989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z)-protosta-17(20),24-dien-3beta-ol => (S)-2,3-epoxysqualene
REACT:R-RNO-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Rattus norvegicus)
REACT:R-XTR-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Xenopus tropicalis)
RHEA:68158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N-geranyl-L-glutamate => (2E)-geranyl diphosphate + L-glutamate
REACT:R-DRE-1855176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Danio rerio)
RHEA:49798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + glycine => an N-(fatty acyl)-glycine + H2O
RHEA:30153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 H(+) + NADPH => FADH2 + NADP(+)
REACT:R-BTA-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Bos taurus)
REACT:R-DRE-5665761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL3 binds RHOC:GTP (Danio rerio)
RHEA:42644	skos:altLabel	"holo-malonate-decarboxylase synthase"
RHEA:42644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] = diphosphate + holo-[malonate decarboxylase ACP]
RHEA:42644	skos:prefLabel	"malonate decarboxylase holo-[acyl-carrier protein] synthase"
RHEA:42644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malonate decarboxylase holo-[acyl-carrier protein] synthase"
RHEA:42644	skos:altLabel	"holo ACP synthase"
REACT:R-GGA-8869667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxLDL:CD36 binds TLR4:TLR6 (Gallus gallus)
REACT:R-SSC-517536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Sus scrofa)
REACT:R-BTA-2187355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters phosphorylated SMAD2/3 (Bos taurus)
REACT:R-RNO-3000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PLK1 (Rattus norvegicus)
GO:0015506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside permease activity
GO:0015506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside:proton symporter activity
GO:0015506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside:hydrogen symporter activity
GO:0015506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside:hydrogen ion symporter activity
RHEA:61376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate
RHEA:51829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)
REACT:R-DRE-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Danio rerio)
RHEA:11819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> beta-D-fructose 6-phosphate
RHEA:57998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rh2 + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose
RHEA:25495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (-)-beta-phellandrene + diphosphate
REACT:R-XTR-162836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Xenopus tropicalis)
REACT:R-HSA-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Homo sapiens)
GO:0050398	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	WEH
GO:0050398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	wax-ester hydrolase activity
GO:0050398	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	jojoba wax esterase
GO:0050398	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	wax-ester acylhydrolase activity
REACT:R-RNO-5684008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBN binds KPNA2 (Rattus norvegicus)
GO:0015616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA translocase activity
REACT:R-CFA-444773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-TM7 receptors bind chondroitin sulphate (Canis familiaris)
RHEA:19047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalate + CoA + H(+) => acetyl-CoA + H2O + pyruvate
REACT:R-HSA-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Homo sapiens)
RHEA:64674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyl 2-(methylsulfanyl)acetate + CoA => 2-(methylsulfanyl)acetyl-CoA + butan-1-ol
RHEA:63597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine
RHEA:63605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Pyr1]apelin-13 + H2O => [Pyr1]apelin-12 + L-phenylalanine
REACT:R-SSC-2318623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan binds Hyaluronan and HAPLN1 (Sus scrofa)
REACT:R-DRE-110349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of UNG glycosylase by APEX1 at the AP site (Danio rerio)
REACT:R-BTA-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Bos taurus)
REACT:R-GGA-450580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 (hnRNP D0) is ubiquitinylated (Gallus gallus)
REACT:R-DRE-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Danio rerio)
RHEA:11157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-valine + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)
RHEA:36446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochanoclavine-I aldehyde <=> 6,8-dimethyl-6,7-didehydroergoline + H2O
REACT:R-XTR-421426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ProGIP translocates from the ER Lumen to secretory granules (Xenopus tropicalis)
REACT:R-RNO-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Rattus norvegicus)
RHEA:54340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
RHEA:58285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + NADP(+) => H(+) + NADPH + thymine
RHEA:28947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-arabinose(in) = H(+)(in) + L-arabinose(out)
REACT:R-BTA-879910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 is phosphorylated, activated (Bos taurus)
RHEA:56356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)
REACT:R-DRE-9026007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Danio rerio)
RHEA:35367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH = isoheptadecanoyl-coA + NADP(+)
RHEA:14866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + tyramine => H(+) + N-methyltyramine + S-adenosyl-L-homocysteine
REACT:R-GGA-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Gallus gallus)
REACT:R-CEL-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Caenorhabditis elegans)
GO:0036373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-L-fucose 1-epimerase activity
GO:0036373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fucose 1-epimerase activity
GO:0036373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fucose mutarotase activity
GO:0036373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type-2 mutarotase activity
REACT:R-SCE-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Saccharomyces cerevisiae)
REACT:R-SSC-159425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
RHEA:28464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal(out) => pyridoxal(in)
REACT:R-HSA-1220613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-induced dimerization of ligand-responsive EGFR mutants (Homo sapiens)
GO:0047051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lactate dehydrogenase (cytochrome c-553) activity
GO:0047051	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity
REACT:R-CFA-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Canis familiaris)
REACT:R-CEL-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
RHEA:42796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA
REACT:R-XTR-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Xenopus tropicalis)
REACT:R-GGA-351936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of claspin (Gallus gallus)
RHEA:64395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dipeptide(out) + H(+)(out) <=> a dipeptide(in) + H(+)(in)
RHEA:31049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADH + propanoyl-CoA => (S)-methylmalonate semialdehyde + CoA + NAD(+)
REACT:R-HSA-5651789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to POLB ligates SSB (Homo sapiens)
GO:0030767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate 4-C-methyltransferase activity
GO:0030767	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyanthranilate 4-methyltransferase activity
GO:0030767	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity
RHEA:51318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoate + glycine
RHEA:44937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate
REACT:R-DME-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Drosophila melanogaster)
REACT:R-XTR-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Xenopus tropicalis)
REACT:R-HSA-9610879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1 (GRIN1) binds to NEFL at postsynaptic density (Homo sapiens)
REACT:R-XTR-75238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL binds TRAIL receptors (Xenopus tropicalis)
REACT:R-BTA-9024881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Bos taurus)
RHEA:16133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine + O2 = 3-aminopropanal + H2O2 + N(1)-acetylspermidine
REACT:R-SPO-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Schizosaccharomyces pombe)
REACT:R-CEL-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Caenorhabditis elegans)
REACT:R-MMU-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Mus musculus)
RHEA:49511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphinomethylmalate <=> 2-(phosphinatomethylidene)butanedioate + H2O
RHEA:60859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine
REACT:R-CFA-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Canis familiaris)
REACT:R-GGA-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Gallus gallus)
REACT:R-RNO-444126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Rattus norvegicus)
REACT:R-DRE-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Danio rerio)
RHEA:30941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dITP => ATP + dIDP
RHEA:62973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + orsellinate
REACT:R-HSA-428262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Homo sapiens)
REACT:R-BTA-1855208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Bos taurus)
REACT:R-SSC-9749971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Sus scrofa)
RHEA:16820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH
RHEA:24043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 oxidized [cytochrome P450] <=> H(+) + NADP(+) + 2 reduced [cytochrome P450]
RHEA:14592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin + S-adenosyl-L-methionine <=> chrysoeriol + H(+) + S-adenosyl-L-homocysteine
GO:0016597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid binding
REACT:R-MMU-71324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)
REACT:R-XTR-5654562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Xenopus tropicalis)
REACT:R-CFA-2514867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Canis familiaris)
REACT:R-RNO-3222128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOC2L binds TP53 (Rattus norvegicus)
RHEA:69538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => alpha-D-tagatopyranose 1-phosphate + ATP
REACT:R-DME-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Drosophila melanogaster)
RHEA:66277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tigogenin + UDP-alpha-D-glucose => H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP
REACT:R-MMU-8949649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Mus musculus)
REACT:R-CFA-3640861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 ubiquitinates ADP-ribosylated AXIN (Canis familiaris)
GO:0102309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-oxo-2,6-dideoxy-D-glucose 4-ketoreductase (dTDP-D-oliose producing) activity
RHEA:44850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-(9Z)-tetradecenoyl-(R)-carnitine => (9Z)-tetradecenoyl-CoA + (R)-carnitine
REACT:R-SSC-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Sus scrofa)
REACT:R-DME-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Drosophila melanogaster)
RHEA:51622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dCTP + H2O => CTP + formate + H(+)
REACT:R-HSA-1307963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)
REACT:R-GGA-353044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phosphoglycerate <=> phosphoenolpyruvate + H2O (Gallus gallus)
REACT:R-MMU-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)
REACT:R-HSA-9009488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 binds CSF1 (Homo sapiens)
RHEA:20879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-BTA-606349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mis18 complex binds the centromere (Bos taurus)
RHEA:27801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-octaprenyl diphosphate + 5 diphosphate
RHEA:20751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + penicillin N <=> CO2 + deacetoxycephalosporin C + H2O + succinate
RHEA:49080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5-oxide + FMNH2 + O2 = dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O
RHEA:61186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP => quercitrin + UDP-beta-L-rhamnose
REACT:R-GGA-2129385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFAP2, MFAP5 bind microfibrils (Gallus gallus)
REACT:R-SSC-9603986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 chains to form LeA (Sus scrofa)
RHEA:57857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + 2-oxoglutarate + O2 => (E)-6-hydroxyferuloyl-CoA + CO2 + succinate
RHEA:20874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb1 + H(+) + UDP => (20S)-ginsenoside Rd + UDP-alpha-D-glucose
RHEA:52645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,4-lactone 5-phosphate + H2O => 5-phospho-D-xylonate + H(+)
REACT:R-SSC-396996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs binds G-protein Gq (Sus scrofa)
REACT:R-BTA-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Bos taurus)
RHEA:50272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = resolvin E1
REACT:R-HSA-452331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TBXT (T, Brachyury) in the primitive streak (Homo sapiens)
REACT:R-HSA-9662837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S,T-ADAM17(215-827):Zn2+ cleaves CD163 (Homo sapiens)
REACT:R-CFA-209815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is monoiodinated (Canis familiaris)
RHEA:53212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <=> di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP
REACT:R-SSC-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Sus scrofa)
REACT:R-DDI-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)
REACT:R-RNO-9728664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1R agonists (Rattus norvegicus)
REACT:R-HSA-9617996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Homo sapiens)
REACT:R-XTR-158311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Xenopus tropicalis)
REACT:R-BTA-4551655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Bos taurus)
REACT:R-RNO-5665767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FMNL3 binds G-actin (Rattus norvegicus)
RHEA:66745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-aspartate(in) => ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate
REACT:R-HSA-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Homo sapiens)
RHEA:44282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA
REACT:R-BTA-2022860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Bos taurus)
RHEA:56735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dihydroxy-all-trans-beta-carotene <=> echinenone + H2O
RHEA:36638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine
RHEA:72429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + K(+)(out) => chloride(in) + K(+)(in)
REACT:R-BTA-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)
REACT:R-BTA-374899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of noradrenaline  at the synapse (Bos taurus)
REACT:R-GGA-9603419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds SRC (Gallus gallus)
RHEA:50199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
REACT:R-MMU-9731393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA, EDNRB bind non-selective ERAs (Mus musculus)
REACT:R-MMU-749452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gq complex dissociates (Mus musculus)
REACT:R-RNO-72231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Cleavage and Polyadenylation Complex (Rattus norvegicus)
REACT:R-CFA-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Canis familiaris)
RHEA:30157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 Fe(2+) + 3 H(+) => FADH2 + 2 Fe(3+)
RHEA:19642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + ATP + CoA => (E)-4-coumaroyl-CoA + AMP + diphosphate
GO:0033996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity
GO:0033996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	levan fructotransferase activity
GO:0033996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity
GO:0033996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	levan fructotransferase (DFA-IV-forming) activity
RHEA:41883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-[ACP] + H(+) + NADPH <=> dodecanoyl-[ACP] + NADP(+)
RHEA:62697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 4 tellimagrandin II => 2 cornusiin E + 2 H2O
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine, queuine-tRNA transglycosylase activity
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Q-insertase activity
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	queuine transfer ribonucleate ribosyltransferase activity
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-guanosine(34) preQ1 transglycosylase.
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transfer ribonucleate glycosyltransferase activity
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA guanine transglycosidase activity
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	queuine tRNA-ribosyltransferase activity
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eTGT
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA transglycosylase activity
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-guanine transglycosylase activity
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA guanine transglycosylase
GO:0008479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanine insertion enzyme activity
REACT:R-CFA-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Canis familiaris)
RHEA:31820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => 5-epi-alpha-selinene + diphosphate
REACT:R-HSA-8955893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS4 gene expression is inhibited by RUNX1 (Homo sapiens)
REACT:R-SSC-445699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Sus scrofa)
REACT:R-HSA-113449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Transcriptional Pause at Terminator Sequence (Homo sapiens)
REACT:R-XTR-8987141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)
REACT:R-SPO-4085331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-1 SUMOylates PARK7 with SUMO1 (Schizosaccharomyces pombe)
RHEA:50401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[PqsC protein] + octanoyl-CoA => CoA + S-octanoyl-L-cysteinyl-[PqsC protein]
REACT:R-CFA-5662620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds cadmium (Canis familiaris)
REACT:R-HSA-167197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating HIV-1 transcript from template (Homo sapiens)
RHEA:28302	skos:prefLabel	"germacrene C synthase"
RHEA:28302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"germacrene C synthase"
RHEA:28302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + germacrene C
REACT:R-CFA-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Canis familiaris)
RHEA:10970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + GDP + phosphate => a carboxylate + CoA + GTP
REACT:R-SSC-428752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:Gq complex (Sus scrofa)
RHEA:22615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA <=> acetyl-CoA + pyruvate
REACT:R-HSA-2399992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates forkhead box transcription factors (Homo sapiens)
REACT:R-HSA-1482857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL transports from the ER to the IM (Homo sapiens)
REACT:R-RNO-177933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by phosphorylated EGFR (Rattus norvegicus)
RHEA:67289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine
REACT:R-HSA-1856948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CRY:PER:Kinase complex (Homo sapiens)
GO:1904493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydrofolyl-poly(glutamate) polymer binding
REACT:R-SPO-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)
RHEA:69073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + serotonin => (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
GO:0050509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparan glucuronyltransferase II activity
GO:0050509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
GO:0050509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity
GO:0050509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity
GO:0050509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity
REACT:R-GGA-3465459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Gallus gallus)
REACT:R-MMU-377640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of SRC (Mus musculus)
REACT:R-RNO-170824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Rattus norvegicus)
REACT:R-SSC-6805059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2:FACT phosphorylates TP53 (Sus scrofa)
REACT:R-HSA-9026510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTF4-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)
REACT:R-HSA-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Homo sapiens)
RHEA:72283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
RHEA:35952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate => diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
RHEA:28050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) = NAD(+) + phosphate
REACT:R-HSA-5387389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)
REACT:R-CFA-5635868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-GLI is degraded by the proteasome (Canis familiaris)
REACT:R-DME-2186607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)
GO:0019955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokine binding
GO:0019955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin binding
GO:0019955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL binding
REACT:R-MMU-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Mus musculus)
RHEA:55713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)
RHEA:61498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose
RHEA:12995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-SPO-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Schizosaccharomyces pombe)
RHEA:22014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-5 + S-adenosyl-L-homocysteine => precorrin-4 + S-adenosyl-L-methionine
REACT:R-HSA-5654662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
RHEA:65775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Mus musculus)
RHEA:13819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-epoxyphylloquinone + [protein]-dithiol => [protein]-disulfide + H2O + phylloquinone
RHEA:57426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaiacol + O2 + reduced [NADH--hemoprotein reductase]
REACT:R-CFA-417927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y2 receptor binds ATP and UTP (Canis familiaris)
REACT:R-SCE-8850945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates PTEN (Saccharomyces cerevisiae)
RHEA:47248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone = 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate
RHEA:29855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine = D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate
RHEA:34558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH
RHEA:45737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-hexenoyl-CoA => (2E)-hexenoyl-CoA
RHEA:19377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + reduced riboflavin = 2 H(+) + NADPH + riboflavin
REACT:R-CFA-6799761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds PPP1R13L (Canis familiaris)
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endogalacturonase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pectin depolymerase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly-alpha-1,4-galacturonide glycanohydrolase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polygalacturonase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectin hydrolase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-polygalacturonase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectolase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endopolygalacturonase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pectinase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-D-galacturonase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(1,4-alpha-D-galacturonide) glycanohydrolase activity
GO:0004650	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectin polygalacturonase activity
GO:0052662	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	antheraxanthin epoxidase activity
GO:0052662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zeaxanthin epoxidase [overall] activity
GO:0052662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zeaxanthin epoxidase activity
GO:0052662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zea-epoxidase activity
REACT:R-HSA-8865256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)
REACT:R-BTA-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)
RHEA:28745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(out) + nitrite(in) => nitrate(in) + nitrite(out)
GO:0008759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
REACT:R-DME-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)
RHEA:40810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine
REACT:R-MMU-6810464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT14 hydrolyses UDP-Glc to G1P and UMP (Mus musculus)
REACT:R-BTA-1504213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Bos taurus)
REACT:R-SSC-8855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR:DAB1 binds SH3KBP1 (Sus scrofa)
REACT:R-XTR-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Xenopus tropicalis)
RHEA:27866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + alpha-D-mannose 6-phosphate
RHEA:20422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltose 6'-phosphate + H2O => D-glucose + D-glucose 6-phosphate
RHEA:27660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate => 2-deoxy-alpha-D-ribose 1-phosphate
REACT:R-BTA-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Bos taurus)
RHEA:12491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)
REACT:R-HSA-6793122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145 (Homo sapiens)
REACT:R-SSC-8857555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates GPNMB (Sus scrofa)
RHEA:32456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone
REACT:R-MMU-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Mus musculus)
RHEA:63331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + ATP <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-HSA-419981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Homo sapiens)
REACT:R-BTA-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Bos taurus)
REACT:R-BTA-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Bos taurus)
REACT:R-BTA-190427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1b (Bos taurus)
GO:0016163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrogenase activity
GO:0016163	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vanadium-iron nitrogenase activity
GO:0016163	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	iron-iron nitrogenase activity
GO:0016163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity
GO:0016163	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	molybdenum-iron nitrogenase activity
RHEA:71714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-tyrosylglycine(out) <=> H(+)(in) + L-tyrosylglycine(in)
REACT:R-BTA-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Bos taurus)
RHEA:19696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) <=> 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH
RHEA:60980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxydodecanoate + NAD(+) = 12-oxododecanoate + H(+) + NADH
REACT:R-SSC-2730864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TRAF6 to CBM complex by binding to MALT1 (Sus scrofa)
RHEA:65122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine => H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione
GO:0043883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MleS
GO:0043883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malolactic enzyme activity
REACT:R-SSC-5625424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The retrograde IFT train dissociates (Sus scrofa)
RHEA:64344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 = 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)
REACT:R-DRE-210283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and PLC gamma1 (Danio rerio)
REACT:R-GGA-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Gallus gallus)
GO:0050014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ketotetrose-phosphate aldolase activity
GO:0050014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythrulose-1-phosphate formaldehyde-lyase activity
GO:0050014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoketotetrose aldolase activity
GO:0050014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)
GO:0050014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythrose-1-phosphate synthase activity
GO:0050014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythrulose-1-phosphate synthetase activity
REACT:R-BTA-266012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTD4 is converted to LTE4 by DPEP1/2 (Bos taurus)
REACT:R-HSA-9687638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds IP4, IP5 and IP6  (Homo sapiens)
REACT:R-XTR-379395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates 3MT to HVA (Xenopus tropicalis)
REACT:R-HSA-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Homo sapiens)
REACT:R-SPO-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Schizosaccharomyces pombe)
RHEA:34733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acyl-CoA
REACT:R-GGA-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Gallus gallus)
RHEA:47091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH
REACT:R-CEL-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Caenorhabditis elegans)
RHEA:50516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]
REACT:R-RNO-8874979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD3 binds GOLGB1 (Rattus norvegicus)
GO:0047800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminoethanethiol:oxygen oxidoreductase activity
GO:0047800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteamine dioxygenase activity
GO:0047800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteamine oxygenase activity
GO:0047800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteamine:oxygen oxidoreductase activity
GO:0047800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	persulfurase activity
RHEA:21370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyisourate + H2O2 => H2O + O2 + urate
RHEA:25497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (1S,5S)-beta-pinene + diphosphate
RHEA:41107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate
RHEA:17621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + citramalate = (3S)-citramalyl-CoA + acetate
RHEA:17621	skos:prefLabel	"citramalate CoA-transferase"
RHEA:17621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citramalate CoA-transferase"
RHEA:58543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-dodecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine
REACT:R-CFA-469659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A1 dehydrogenates TEST to DHTEST (Canis familiaris)
REACT:R-GGA-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Gallus gallus)
REACT:R-SSC-9796691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPATA2 links CYLD to LUBAC (Sus scrofa)
REACT:R-BTA-159425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
RHEA:20392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)
REACT:R-GGA-9008052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10(?-152) binds IL1RAPL1 (Gallus gallus)
RHEA:33510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine 1-phosphate <=> (2E)-hexadecenal + phosphoethanolamine
REACT:R-MMU-444527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR is a receptor for formyl peptides (Mus musculus)
EC:3.-.-.-	skos:prefLabel	"Hydrolases"
EC:3.-.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hydrolases"
RHEA:53683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
REACT:R-CFA-383313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like Peptide 1 is secreted from intestinal L cells (Canis familiaris)
REACT:R-DME-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Drosophila melanogaster)
REACT:R-PFA-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Plasmodium falciparum)
REACT:R-DRE-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Danio rerio)
RHEA:41271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-RNO-8950453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Rattus norvegicus)
GO:0052728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	violaxanthin-capsorubin isomerase (ketone-forming) activity
GO:0052728	skos:altLabel	"CCS"
GO:0052728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	capsorubin synthase activity
GO:0052728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"capsanthin/capsorubin synthase"
GO:0052728	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	capsanthin-capsorubin synthase activity
GO:0052728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CCS
GO:0052728	skos:altLabel	"ketoxanthophyll synthase"
GO:0052728	skos:altLabel	"capsanthin-capsorubin synthase"
GO:0052728	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ketoxanthophyll synthase activity
GO:0052728	skos:prefLabel	"capsanthin/capsorubin synthase"
REACT:R-DME-5625717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PKN1 binds androgen receptor (AR) (Drosophila melanogaster)
REACT:R-SSC-420274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIP receptor binds gastric inhibitory peptide (Sus scrofa)
RHEA:38385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O
REACT:R-HSA-2046097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)
RHEA:56557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => delta-cadinene + diphosphate
RHEA:34024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH
REACT:R-DDI-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Dictyostelium discoideum)
RHEA:44461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine
GO:0004957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGE(2) receptor activity
GO:0004957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E receptor activity
GO:0004957	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGE receptor activity
GO:0017159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vanin-1
GO:0017159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-pantetheine amidohydrolase activity
GO:0017159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantetheinase activity
GO:0017159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pantetheine hydrolase activity
GO:0017159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vanin
REACT:R-CEL-164834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enzyme-bound ATP is released (Caenorhabditis elegans)
REACT:R-HSA-5655235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
RHEA:49426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + validone 7-phosphate => ATP + validone
RHEA:62808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0000026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,2-mannosyltransferase activity
REACT:R-BTA-9734475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds fibrates (Bos taurus)
REACT:R-DRE-8876319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC50A1 transports Glc from cytosol to extracellular region (Danio rerio)
RHEA:57993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside C-K + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP
RHEA:63769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine
REACT:R-BTA-9731228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)
REACT:R-HSA-9625188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)
RHEA:71474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P <=> L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)
REACT:R-SSC-8875490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind ubiquitinated MET (Sus scrofa)
RHEA:21637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP
REACT:R-CFA-2485148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Canis familiaris)
REACT:R-DRE-6807134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)
REACT:R-DRE-1482543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Danio rerio)
GO:0140339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylglycerol carrier activity
GO:0140339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylglycerol transfer activity
EC:3.4.24.38	skos:prefLabel	"gametolysin"
EC:3.4.24.38	skos:altLabel	"autolysin"
EC:3.4.24.38	skos:altLabel	"gamete lytic enzyme"
EC:3.4.24.38	skos:altLabel	"Chlamydomonas cell wall degrading protease"
EC:3.4.24.38	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gametolysin"
EC:3.4.24.38	skos:altLabel	"lysin"
RHEA:33213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-7 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+)
REACT:R-MMU-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Mus musculus)
RHEA:45709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnitine + acetyl-CoA => 3-dehydrocarnityl-CoA + acetate
RHEA:30253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinone + n H(+)(out) + 2 H2O => 2 a ubiquinol + n H(+)(in) + O2
REACT:R-DRE-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Danio rerio)
REACT:R-HSA-5662891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pheomelanin formation (Homo sapiens)
RHEA:63918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-fluorouridine 5'-phosphate + ADP + H(+) => 5-fluorouridine + ATP
REACT:R-DDI-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Dictyostelium discoideum)
REACT:R-RNO-8937177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD binds ARNT (Rattus norvegicus)
RHEA:44498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine
REACT:R-CFA-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Canis familiaris)
REACT:R-MMU-981497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Mus musculus)
RHEA:36273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + NADP(+) + theobromine => caffeine + H(+) + NADPH + O2
REACT:R-CFA-72130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of an intermediate Spliceosomal C complex (Canis familiaris)
REACT:R-DME-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Drosophila melanogaster)
RHEA:15017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phosphate monoester + H2O = an alcohol + phosphate
REACT:R-HSA-176101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Rad17-RFC complex to DNA (Homo sapiens)
REACT:R-SSC-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Sus scrofa)
REACT:R-SSC-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Sus scrofa)
RHEA:64117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine
REACT:R-PFA-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)
REACT:R-HSA-9618479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA1 mRNA is translated (Homo sapiens)
REACT:R-GGA-4570463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Gallus gallus)
REACT:R-CFA-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Canis familiaris)
REACT:R-HSA-444606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R2/T1R3 dimer is a sweet taste receptor (Homo sapiens)
REACT:R-HSA-1222641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carboxymycobactin binds LTF:2xFe3+:2xCO3(2-) (Homo sapiens)
REACT:R-HSA-446870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated TRAF6 binds the TAK1 complex (Homo sapiens)
REACT:R-XTR-390835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD1,5 bind DA (Xenopus tropicalis)
GO:0036424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phosphoserine phosphatase activity
GO:0036424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoserine phosphatase activity
GO:0036424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-phosphoserine phosphohydrolase activity
GO:0102585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity
REACT:R-HSA-9036046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective IDS does not hydrolyse Heparan sulfate chain(5) (Homo sapiens)
REACT:R-SSC-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Sus scrofa)
RHEA:35089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine + N-acetyl-D-glucosamine 6-phosphate => H2O + N'-monoacetylchitobiose-6'-phosphate
REACT:R-RNO-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Rattus norvegicus)
RHEA:33026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NAD(+) <=> CO2 + D-ribulose 5-phosphate + NADH
RHEA:62867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine <=> 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-9033516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)
RHEA:71545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphomethyl-dUMP in DNA + ADP + H(+) => 5-hydroxymethyl-dUMP in DNA + ATP
GO:0022858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine transmembrane transporter activity
RHEA:62660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol = (2'R)-atrovenetin
RHEA:32618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeraniol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH
REACT:R-CFA-430311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rsu-1 interacts with Pinch1 (Canis familiaris)
REACT:R-XTR-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Xenopus tropicalis)
RHEA:20616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine <=> adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine
REACT:R-HSA-190681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in endoplasmic reticulum membrane (Homo sapiens)
GO:0052719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP endoribonuclease activity
GO:0052719	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	apurinic endoribonuclease activity
GO:0052719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abasic endoribonuclease activity
GO:0052719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apurinic/apyrimidinic endoribonuclease activity
GO:0052719	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	apyrimidinic endoribonuclease activity
REACT:R-XTR-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Xenopus tropicalis)
RHEA:11998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,3-diol + H2O + NAD(+) => biphenyl-2-ol + H(+) + NADH + O2
REACT:R-RNO-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)
RHEA:66247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + IC-asc-C9 <=> diphosphate + IC-asc-C9-AMP
RHEA:25521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + pseudotropine => CoA + H(+) + O-acylpseudotropine
GO:0050734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxycinnamoyltransferase activity
GO:0043424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-protein kinase binding
GO:0043424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-histidine kinase binding
GO:0043424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine kinase binding
GO:0043424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein histidine kinase binding
RHEA:35622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idarate <=> D-glucarate
RHEA:60390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) => Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O
REACT:R-DDI-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Dictyostelium discoideum)
RHEA:64208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-glutamine + H2O = a fatty acid + L-glutamine
REACT:R-RNO-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)
REACT:R-RNO-8985973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Rattus norvegicus)
RHEA:21665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate
REACT:R-SSC-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Sus scrofa)
RHEA:26204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammeline + H(+) + H2O <=> ammelide + NH4(+)
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine:dioxovalerate transaminase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminolevulinic acid transaminase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine:4,5-dioxovaleric acid transaminase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminolevulinate:pyruvate aminotransferase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,5-dioxovalerate aminotransferase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminolevulinate transaminase"
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dioxovalerate transaminase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,5-dioxovaleric acid transaminase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-gamma,delta-dioxovalerate aminotransferase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,5-dioxovaleric transaminase activity
GO:0047665	skos:prefLabel	"aminolevulinate transaminase"
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminolevulinic acid transaminase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine-4,5-dioxovalerate aminotransferase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma,delta-dioxovalerate aminotransferase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma,delta-dioxovaleric acid transaminase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminolevulinate transaminase activity
GO:0047665	skos:altLabel	"aminolevulinate aminotransferase"
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,5-dioxovaleric acid aminotransferase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine:4,5-dioxovalerate aminotransferase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DOVA transaminase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminolevulinate aminotransferase activity
GO:0047665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-dioxovalerate aminotransferase activity
REACT:R-RNO-442291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV2 is a GEF for Rho/Rac family kinases (Rattus norvegicus)
RHEA:40806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADPH
REACT:R-MMU-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Mus musculus)
RHEA:47330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O
REACT:R-MMU-196086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Mus musculus)
REACT:R-HSA-9709885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL scavenges NO (Homo sapiens)
RHEA:54236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-CEL-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Caenorhabditis elegans)
RHEA:52691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH
RHEA:33016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 => [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)
REACT:R-HSA-9724090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYH9- and RNF213-ALK fusions are phosphorylated (Homo sapiens)
REACT:R-BTA-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Bos taurus)
RHEA:48590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 lipoxin B4 => 2 H2O + 2 leukotriene A4 + O2
REACT:R-HSA-5671970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CIT binds KIF14 and PRC1 (Homo sapiens)
REACT:R-CFA-9749197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 binds to H4K20me2 (Canis familiaris)
REACT:R-DME-350377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular domains of STAN bind to each other in adjacent cells (Drosophila melanogaster)
REACT:R-MMU-8981657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds PTPRZ1 (Mus musculus)
RHEA:18050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(2)-acetyl-L-ornithine => L-glutamate + N-acetyl-L-glutamate 5-semialdehyde
REACT:R-MMU-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Mus musculus)
RHEA:32887	skos:altLabel	"beta-carotene 15,15'-monooxygenase"
RHEA:32887	skos:altLabel	"carotene dioxygenase"
RHEA:32887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + O2 = 2 all-trans-retinal
RHEA:32887	skos:altLabel	"carotene 15,15'-dioxygenase"
RHEA:32887	skos:prefLabel	"beta-carotene 15,15'-dioxygenase"
RHEA:32887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-carotene 15,15'-dioxygenase"
RHEA:66038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O
REACT:R-MMU-5662620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds cadmium (Mus musculus)
REACT:R-RNO-202291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Lck (Rattus norvegicus)
RHEA:38553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2
GO:0097263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eoxin E4 synthase activity
GO:0097263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXD4 is converted to EXE4 by DPEP (Homo sapiens)
EC:2.7.4.12	skos:prefLabel	"T2-induced deoxynucleotide kinase"
EC:2.7.4.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"T2-induced deoxynucleotide kinase"
REACT:R-DRE-9011983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Danio rerio)
RHEA:17869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + H(+) + NADH
GO:0031706	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	subtype 3 bombesin receptor ligand
GO:0031706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	subtype 3 bombesin receptor binding
REACT:R-MMU-6805103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates TP53 (Mus musculus)
REACT:R-RNO-174451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of DNA2 endonuclease to the C strand (Rattus norvegicus)
REACT:R-SSC-5654658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS bind to PPTN11 (Sus scrofa)
REACT:R-SSC-8953461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Sus scrofa)
GO:0072328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkene binding
RHEA:35047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin
RHEA:35047	skos:prefLabel	"molybdopterin molybdotransferase"
RHEA:35047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"molybdopterin molybdotransferase"
RHEA:69910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + uridine(out) <=> 2 Na(+)(in) + uridine(in)
RHEA:49098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine => H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine
GO:0018478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate-semialdehyde dehydrogenase (acetylating) activity
GO:0018478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)
GO:0018478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonic semialdehyde oxidative decarboxylase activity
REACT:R-SSC-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Sus scrofa)
REACT:R-DME-111289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)
RHEA:28012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanoate + succinyl-CoA => propanoyl-CoA + succinate
RHEA:24881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + L-sorbopyranose <=> 1-dehydro-L-sorbose + AH2
REACT:R-BTA-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Bos taurus)
REACT:R-GGA-114352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of tBID by BCL-2 (Gallus gallus)
RHEA:39845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + CoA => 1,3-diacyl-sn-glycerol + an acyl-CoA
REACT:R-HSA-8931981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ESR1 (Homo sapiens)
REACT:R-MMU-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
REACT:R-HSA-198732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 activation (Homo sapiens)
REACT:R-CFA-9014449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the plasma membrane (Canis familiaris)
REACT:R-HSA-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Homo sapiens)
REACT:R-RNO-6805792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S291-PHF20 translocates to cytosol (Rattus norvegicus)
REACT:R-CEL-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)
RHEA:55601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphoceramide + GDP + H(+)
RHEA:46979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2
RHEA:71892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:AcpM transacylase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAT
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[acyl-carrier-protein] S-malonyltransferase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-carrier-protein S-malonyltransferase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP S-malonyltransferase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl carrier proteinmalonyltransferase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FabD
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MCAT activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl carrier protein malonyltransferase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl coenzyme A-acyl carrier protein transacylase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA-acyl carrier protein transacylase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[acyl-carrier protein] S-malonyltransferase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	malonyl transferase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:acyl carrier protein transacylase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:ACP transacylase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	malonyl transacylase activity
GO:0004314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity
REACT:R-CFA-8851494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase7 hydrolyzes nucleoside triphosphates (Canis familiaris)
REACT:R-RNO-8849906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM1 binds NMDA receptor (Rattus norvegicus)
REACT:R-HSA-9714363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC translocates to the endoplasmic reticulum membrane (Homo sapiens)
REACT:R-XTR-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Xenopus tropicalis)
RHEA:59078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+) => bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose
REACT:R-HSA-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Homo sapiens)
REACT:R-RNO-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Rattus norvegicus)
REACT:R-XTR-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
REACT:R-MMU-5228523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates MDM2 with SUMO1 (Mus musculus)
REACT:R-HSA-1368069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors. (Homo sapiens)
REACT:R-CFA-5665761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL3 binds RHOC:GTP (Canis familiaris)
REACT:R-XTR-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Xenopus tropicalis)
RHEA:30350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + IDP <=> ADP + ITP
RHEA:49245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin E1 => 18-oxo-resolvin E1 + H(+) + NADH
REACT:R-MMU-2076419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Mus musculus)
REACT:R-RNO-140870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Rattus norvegicus)
RHEA:37629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine
GO:0001635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGRP receptor
GO:0001635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitonin gene-related peptide receptor activity
GO:0001635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitonin gene-related polypeptide receptor activity
RHEA:53920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]
GO:0080030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeIAA esterase activity
GO:0080030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-Acetic acid methyl ester esterase activity
GO:0080030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl indole-3-acetate esterase activity
GO:0080030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methyl IAA esterase activity
REACT:R-RNO-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Rattus norvegicus)
REACT:R-HSA-74716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin binds the insulin receptor (Homo sapiens)
RHEA:30002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + spermidine(out) <=> ADP + H(+) + phosphate + spermidine(in)
REACT:R-MMU-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Mus musculus)
REACT:R-MMU-933531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)
RHEA:70535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)
REACT:R-MMU-936380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PIN1 with p-IRF3 (Mus musculus)
RHEA:67937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxy carboxylate + O2 => a 2-oxocarboxylate + H2O2
RHEA:11895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-methylnorlaudanosoline + S-adenosyl-L-methionine <=> H(+) + nororientaline + S-adenosyl-L-homocysteine
REACT:R-GGA-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Gallus gallus)
RHEA:45279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-phosphooxy-(9E)-octadecenoate + H2O <=> 12-hydroxy-(9E)-octadecenoate + phosphate
REACT:R-CFA-392187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated P2Y purinoceptor 12 binds G-protein Gi (Canis familiaris)
REACT:R-MMU-2393954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)
RHEA:29542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:11833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene-1,2-diol
REACT:R-HSA-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Homo sapiens)
REACT:R-CFA-9014433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GEFs activate RHOG (Canis familiaris)
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA formation factors, PF1
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(A) synthetase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP polynucleotidylexotransferase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(A) hydrolase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyadenylic acid polymerase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-polynucleotide adenylyltransferase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(A) polymerase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyadenylate nucleotidyltransferase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly-A polymerase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyadenylic polymerase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:polynucleotidylexotransferase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine triphosphate:ribonucleic acid adenylyltransferase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyadenylate polymerase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NTP polymerase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	terminal riboadenylate transferase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA adenylating enzyme activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polynucleotide adenylyltransferase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:polynucleotide adenylyltransferase activity
GO:0004652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyadenylate synthetase activity
REACT:R-DDI-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Dictyostelium discoideum)
REACT:R-DRE-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Danio rerio)
REACT:R-BTA-5696183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC3 deaminates BZAM (Bos taurus)
REACT:R-MMU-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Mus musculus)
REACT:R-CEL-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Caenorhabditis elegans)
REACT:R-RNO-5683801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates BRCA1 (Rattus norvegicus)
REACT:R-DME-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Drosophila melanogaster)
REACT:R-SSC-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Sus scrofa)
RHEA:31729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-phenyloxirane + FAD + H(+) + H2O => FADH2 + O2 + styrene
REACT:R-RNO-2294590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds phosphorylated condensin II complex (Rattus norvegicus)
REACT:R-SSC-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Sus scrofa)
RHEA:24510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin E2 => NADP(+) + prostaglandin F2alpha
REACT:R-HSA-9606160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)
RHEA:67624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:69883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(out) + 2 Na(+)(out) = L-ascorbate(in) + 2 Na(+)(in)
REACT:R-RNO-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Rattus norvegicus)
REACT:R-HSA-2981040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC12:ligand is endocytosed (Homo sapiens)
RHEA:66608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O = GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)
REACT:R-SSC-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Sus scrofa)
RHEA:13020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + UMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + uracil
RHEA:54860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranial + H(+) + NADPH + O2 = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)
RHEA:52508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate(in) + citrate(out) => cis-aconitate(out) + citrate(in)
REACT:R-CFA-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Canis familiaris)
RHEA:25670	skos:prefLabel	"loliose synthase"
RHEA:25670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + UDP-alpha-D-galactose = H(+) + loliose + UDP
RHEA:25670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"loliose synthase"
REACT:R-CEL-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
GO:0070698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I activin receptor binding
RHEA:62446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine + L-canaline => L-canavanine + L-ornithine
RHEA:35470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)
RHEA:68256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine(in) + Na(+)(in) = L-cystine(out) + Na(+)(out)
RHEA:21886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + sulfate + thiosulfate => H2O + trithionate
RHEA:57289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O => a guanosine in RNA + H(+) + lactate
RHEA:56786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O
REACT:R-MMU-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)
REACT:R-HSA-1176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
REACT:R-BTA-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Bos taurus)
RHEA:72570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(in) + propanoate(out) <=> dehydroepiandrosterone 3-sulfate(out) + propanoate(in)
REACT:R-DRE-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Danio rerio)
RHEA:31477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP => soyasapogenol B + UDP-alpha-D-glucuronate
RHEA:25499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (1S,5S)-beta-pinene + diphosphate
GO:0102198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate 5-dehydrogenase activity (NAD-dependent)
REACT:R-SSC-69299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds geminin (Sus scrofa)
REACT:R-HSA-171011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding and activation of MAP Kinase (Homo sapiens)
RHEA:48765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) => 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH
REACT:R-BTA-8952382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 polyubiquitinates RUNX3 (Bos taurus)
RHEA:30568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate => 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate
REACT:R-BTA-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Bos taurus)
GO:0050233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + O2 = 2-dehydro-D-glucose + H2O2
GO:0050233	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyranose:oxygen 2-oxidoreductase activity
GO:0050233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyranose oxidase"
GO:0050233	skos:altLabel	"glucose 2-oxidase"
GO:0050233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyranose oxidase activity
GO:0050233	skos:prefLabel	"pyranose oxidase"
GO:0050233	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyranose-2-oxidase activity
GO:0050233	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose 2-oxidase activity
RHEA:39206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetracosenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetracosanoyl-CoA
REACT:R-MMU-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Mus musculus)
RHEA:15906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxycyclohexanone + A => AH2 + cyclohexane-1,3-dione
RHEA:40951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(2)-acetyl-L-2,4-diaminobutanoate deacetylase"
RHEA:40951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetamido-4-aminobutanoate + H2O = acetate + L-2,4-diaminobutanoate
RHEA:40951	skos:prefLabel	"N(2)-acetyl-L-2,4-diaminobutanoate deacetylase"
RHEA:30031	skos:altLabel	"muconate lactonizing enzyme"
RHEA:30031	skos:altLabel	"muconate cycloisomerase I"
RHEA:30031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"muconate cycloisomerase"
RHEA:30031	skos:altLabel	"cis,cis-muconate lactonizing enzyme I"
RHEA:30031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-muconolactone = cis,cis-muconate + H(+)
RHEA:30031	skos:prefLabel	"muconate cycloisomerase"
REACT:R-HSA-9687377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
REACT:R-HSA-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Homo sapiens)
RHEA:66466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O
GO:0046904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium oxalate binding
REACT:R-MMU-9037761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Mus musculus)
RHEA:32141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + malonyl-CoA => ATP + CoA + malonate
RHEA:44804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) = 2-demethylmenaquinol-9 + CO2 + diphosphate
REACT:R-CFA-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Canis familiaris)
REACT:R-SSC-420724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds Ca2+ (Sus scrofa)
GO:0034432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity
GO:0034432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP5A hydrolase activity
GO:0034432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(5'-adenosyl)-pentaphosphatase activity
GO:0034432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-5-A hydrolase activity
GO:0034432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP(5)A hydrolase activity
GO:0034432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ap5a pyrophosphohydrolase activity
REACT:R-RNO-381466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Rattus norvegicus)
REACT:R-DME-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Drosophila melanogaster)
REACT:R-HSA-5654562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Homo sapiens)
RHEA:20809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-7-O-acetylneuraminate
REACT:R-SSC-373705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of DCC (Sus scrofa)
RHEA:34809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Gallus gallus)
RHEA:57770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylcatechol + NAD(+) + nitrite => 2-nitrotoluene + NADH + O2
REACT:R-DME-5654701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
RHEA:44999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + acetoacetyl-CoA <=> CoA + O-3-oxobutanoyl-(R)-carnitine
REACT:R-DDI-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Dictyostelium discoideum)
RHEA:64297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH => (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)
REACT:R-DRE-389941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP-1 and SHP-2 bind pBTLA (Danio rerio)
REACT:R-CFA-8875659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Canis familiaris)
RHEA:41998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose
RHEA:28100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + guanosine 3',5'-bis(diphosphate) => ATP + GDP
REACT:R-XTR-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Xenopus tropicalis)
REACT:R-SSC-202291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Lck (Sus scrofa)
RHEA:51985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Sus scrofa)
REACT:R-DRE-5661114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Danio rerio)
REACT:R-HSA-376141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ABL with ROBO1:SLIT2 (Homo sapiens)
REACT:R-RNO-353125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteosome degrades ODC holoenzyme complex (Rattus norvegicus)
RHEA:66739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-citrylglutamate(in) + H2O <=> ADP + beta-citrylglutamate(out) + H(+) + phosphate
REACT:R-XTR-9757688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDN (Xenopus tropicalis)
REACT:R-CEL-3204318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Caenorhabditis elegans)
RHEA:25395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
RHEA:25395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linoleate 8R-lipoxygenase"
RHEA:25395	skos:altLabel	"5,8-linoleate diol synthase (bifunctional enzyme)"
RHEA:25395	skos:prefLabel	"linoleate 8R-lipoxygenase"
RHEA:25395	skos:altLabel	"7,8-linoleate diol synthase (bifunctional enzyme)"
REACT:R-MMU-9678737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR1:TYK2 binds TYK2 inhibitors (Mus musculus)
REACT:R-DME-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Drosophila melanogaster)
REACT:R-HSA-163756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of fatty acid synthase (FAS) dimer (Homo sapiens)
REACT:R-MMU-5695989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD11 dehydrogenates BH-CoA (Mus musculus)
RHEA:40045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-citrylglutamate + H(+) + phosphate => ATP + citrate + L-glutamate
REACT:R-BTA-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)
RHEA:61634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + 2 H(+) + NADH => 5-aminopentanal + H2O + NAD(+)
RHEA:34907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdate(in) = molybdate(out)
RHEA:24925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + NH4(+) => L-homoserine
REACT:R-RNO-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Rattus norvegicus)
RHEA:35023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone O-beta-D-glucopyranoside(out) = hydroquinone O-beta-D-glucopyranoside(in)
RHEA:20437	skos:prefLabel	"D-pinitol dehydrogenase"
RHEA:20437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH
RHEA:20437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-pinitol dehydrogenase"
GO:0102163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyacyl-CoA-acyl carrier protein transferase activity
REACT:R-XTR-190388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3c (Xenopus tropicalis)
REACT:R-BTA-8866327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL translocates from SER lumen to extracellular region (Bos taurus)
REACT:R-CEL-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Caenorhabditis elegans)
RHEA:28367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-GGA-204008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC31:SEC13 and v-SNARE recruitment (Gallus gallus)
REACT:R-DRE-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Danio rerio)
RHEA:36466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamate + H2O <=> glycine + L-glutamate
RHEA:15131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CEL-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Caenorhabditis elegans)
RHEA:53928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-8848812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF1A,EPAS1 bind PTK6 gene (Homo sapiens)
REACT:R-XTR-8858500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC10A binds Tn-MUC1 (Xenopus tropicalis)
RHEA:17769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choline monooxygenase"
RHEA:17769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:17769	skos:prefLabel	"choline monooxygenase"
REACT:R-RNO-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Rattus norvegicus)
RHEA:24593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + phosphoethanolamine => CDP-ethanolamine + diphosphate
REACT:R-DRE-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Danio rerio)
REACT:R-CEL-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Caenorhabditis elegans)
GO:0036239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxoid 7beta-hydroxylase activity
REACT:R-GGA-8876484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 transfers CHOL to NPC1 (Gallus gallus)
RHEA:32998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:21281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 O2 + thiamine => H(+) + 2 H2O2 + thiamine acetate
REACT:R-BTA-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Bos taurus)
RHEA:28486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(in) = Fe(2+)(out)
RHEA:15745	skos:altLabel	"sucrose 1-fructosyltransferase"
RHEA:15745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->1)-beta-D-fructosyl](n) + sucrose = [(2->1)-beta-D-fructosyl](n+1) + D-glucose
RHEA:15745	skos:prefLabel	"inulosucrase"
RHEA:15745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inulosucrase"
REACT:R-HSA-5687875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SFTPA2 does not translocate from ER membrane to extracellular region (Homo sapiens)
RHEA:63352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Rattus norvegicus)
REACT:R-BTA-9733960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids dissociate from ALB (Bos taurus)
REACT:R-CFA-1247497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds neuregulins (Canis familiaris)
REACT:R-MMU-8854736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 binds FLT3 (Mus musculus)
REACT:R-DRE-622310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD1 oligomerizes (Danio rerio)
REACT:R-RNO-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)
REACT:R-HSA-914022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 can recruit GRB2 (Homo sapiens)
REACT:R-SSC-9609743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Sus scrofa)
RHEA:50310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-1855205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)
RHEA:55976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + thiosulfate = H(+) + S-sulfanylglutathione + sulfite
RHEA:24094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2S)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin
RHEA:44906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + phosphate => alpha-D-glucose 6-phosphate + H2O
REACT:R-CFA-202394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CARMA1 to Plasma membrane (Canis familiaris)
RHEA:53460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate
RHEA:56590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + hydrogen cyanide => a monosubstituted aliphatic (S)-hydroxynitrile
REACT:R-GGA-6807106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN undergoes monoubiquitination (Gallus gallus)
REACT:R-HSA-9669878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sunitinib-resistant KIT mutants do not bind sunitinib (Homo sapiens)
RHEA:44449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + CoA
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-diacylglycerol-serine O-phosphatidyltransferase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PS synthase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylserine synthase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diglycerine-serine O-phosphatidyltransferase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylserine synthetase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPdiacylglycerol-serine O-phosphatidyltransferase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	serine exchange enzyme
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diglyceride:serine phosphatidyltransferase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPdiglyceride-serine O-phosphatidyltransferase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity
GO:0003882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diglyceride-L-serine phosphatidyltransferase activity
GO:0140102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalytic activity, acting on a rRNA
RHEA:16606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H2O + oxaloacetate => (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)
RHEA:25471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> beta-himachalene + diphosphate
RHEA:20481	skos:prefLabel	"Renilla-luciferin sulfotransferase"
RHEA:20481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + coelenterazine h = adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate
RHEA:20481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Renilla-luciferin sulfotransferase"
RHEA:20481	skos:altLabel	"luciferin sulfotransferase"
RHEA:16458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH
REACT:R-BTA-6808496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
RHEA:28069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) <=> alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:21144	skos:altLabel	"5,10-methylenetetrahydromethanopterin cyclohydrolase"
RHEA:21144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:21144	skos:prefLabel	"5,10-methylenetetrahydromethanopterin reductase"
RHEA:21144	skos:altLabel	"coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase"
RHEA:21144	skos:altLabel	"N(5),N(10)-methylenetetrahydromethanopterin reductase"
RHEA:21144	skos:altLabel	"N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase"
RHEA:21144	skos:altLabel	"methylene-H4MPT reductase"
RHEA:21144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5,10-methylenetetrahydromethanopterin reductase"
REACT:R-CFA-1247922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCT transforms gGluCys to OPRO (Canis familiaris)
RHEA:65196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine = H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine
REACT:R-MMU-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Mus musculus)
REACT:R-CFA-77615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR2) (Canis familiaris)
REACT:R-DRE-109343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Danio rerio)
RHEA:33076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine => 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine
REACT:R-CFA-1462023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-pro-defensins are cleaved to remove the signal peptide (Canis familiaris)
REACT:R-SSC-1433508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC alpha interacts with and phosphorylates KIT (Sus scrofa)
RHEA:23165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose => a flavonol 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-DRE-3000335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Danio rerio)
RHEA:67231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA <=> (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O
GO:0031855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxytocin receptor binding
GO:0031855	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxytocin receptor ligand
GO:0003829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity
GO:0003829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0003829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta6-N-acetylglucosaminyltransferase activity
GO:0003829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	core 2 acetylglucosaminyltransferase activity
GO:0003829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta(6)-N-acetylglucosaminyltransferase activity
GO:0003829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity
GO:0003829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity
GO:0003829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	core 6-beta-GlcNAc-transferase A
GO:0003829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity
REACT:R-BTA-193964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 21-hydroxylates PROG (Bos taurus)
RHEA:52840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vanillate = 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP
RHEA:18497	skos:altLabel	"L-xylulose 5-phosphate 3-epimerase"
RHEA:18497	skos:prefLabel	"L-ribulose-5-phosphate 3-epimerase"
RHEA:18497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-ribulose-5-phosphate 3-epimerase"
RHEA:18497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose 5-phosphate = L-xylulose 5-phosphate
REACT:R-CFA-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Canis familiaris)
REACT:R-HSA-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)
REACT:R-BTA-165777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4B by activated S6K1 (Bos taurus)
RHEA:53332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol
GO:0016775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphotransferase activity, nitrogenous group as acceptor
RHEA:51592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene = benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:20641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histidinol dehydrogenase"
RHEA:20641	skos:prefLabel	"histidinol dehydrogenase"
RHEA:20641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH
REACT:R-RNO-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Rattus norvegicus)
RHEA:32909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O
RHEA:68475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> (E)-alpha-bisabolene + diphosphate
EC:2.4.99.22	skos:altLabel	"N-acetylglucosaminide (alpha 2->6)-sialyltransferase"
EC:2.4.99.22	skos:altLabel	"alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylglucosaminide 6-alpha-sialyltransferase"
EC:2.4.99.22	skos:prefLabel	"N-acetylglucosaminide alpha-(2,6)-sialyltransferase"
EC:2.4.99.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosaminide alpha-(2,6)-sialyltransferase"
REACT:R-CFA-9750555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Canis familiaris)
REACT:R-DRE-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Danio rerio)
GO:0047676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonoyl-CoA synthetase activity
GO:0047676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonate:CoA ligase (AMP-forming)
GO:0047676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonate-CoA ligase activity
REACT:R-MMU-168849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAX protein (Mus musculus)
GO:0102088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(4-hydroxybenzoyl)-L-glutamate synthetase activity
RHEA:52538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + dGDP + H(+) => adenosine + dGTP
REACT:R-RNO-69891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
REACT:R-HSA-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Homo sapiens)
RHEA:50246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Sus scrofa)
RHEA:13797	skos:altLabel	"dolichol phosphate phosphatase"
RHEA:13797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-phosphatase"
RHEA:13797	skos:prefLabel	"dolichyl-phosphatase"
RHEA:13797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + H2O = di-trans,poly-cis-dolichol + phosphate
RHEA:55624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O = 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)
RHEA:67614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O
REACT:R-BTA-8940074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NMN (Bos taurus)
REACT:R-RNO-373339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Rattus norvegicus)
REACT:R-BTA-437139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT6 transports zinc into the golgi apparatus (Bos taurus)
REACT:R-DDI-6798044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTG2 binds CCR4-NOT complex (Dictyostelium discoideum)
REACT:R-GGA-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Gallus gallus)
REACT:R-BTA-141423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the MCC complex to the APC/C complex (Bos taurus)
REACT:R-DME-2454081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5 oxidises 11cROL to 11cRAL (Drosophila melanogaster)
REACT:R-BTA-6810594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Bos taurus)
RHEA:55941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-3,4-didehydroretinol + NAD(+) => all-trans-3,4-didehydroretinal + H(+) + NADH
REACT:R-HSA-9634446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFI1 gene expression is enhanced by CEBPA (Homo sapiens)
REACT:R-DME-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Drosophila melanogaster)
REACT:R-XTR-193385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of choloyl-CoA to cholate and CoASH (Xenopus tropicalis)
GO:0102193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-ribulosamine 3-kinase activity
REACT:R-XTR-9700149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds PLCG1 (Xenopus tropicalis)
RHEA:62401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-ephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
GO:0102258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacylglycerol acylhydrolase activity
RHEA:13241	skos:altLabel	"L-fucokinase"
RHEA:13241	skos:altLabel	"L-fucose kinase"
RHEA:13241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-fucose = ADP + beta-L-fucose 1-phosphate + H(+)
RHEA:13241	skos:prefLabel	"fucokinase"
RHEA:13241	skos:altLabel	"ATP:6-deoxy-L-galactose 1-phosphotransferase"
RHEA:13241	skos:altLabel	"fucokinase (phosphorylating)"
RHEA:13241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fucokinase"
RHEA:13241	skos:altLabel	"fucose kinase"
REACT:R-MMU-449073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-3 cleaves pro-interleukin-16 (Mus musculus)
RHEA:22018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite + glutathionyl-S-S-[glutaredoxin] + H2O => [glutaredoxin]-dithiol + arsenate + glutathione + H(+)
RHEA:29361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + uridine => H2O + UMP
REACT:R-CFA-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Canis familiaris)
REACT:R-BTA-430021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAN2-PAN3 complex partially deadenylates mRNA (Bos taurus)
REACT:R-MMU-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Mus musculus)
RHEA:71280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-leucine(out) + 2 Na(+)(out) => chloride(in) + L-leucine(in) + 2 Na(+)(in)
REACT:R-BTA-1855169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)
REACT:R-CFA-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Canis familiaris)
REACT:R-CFA-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Canis familiaris)
RHEA:18627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactono-1,5-lactone + H(+) + NADPH => D-galactose + NADP(+)
REACT:R-HSA-389381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gads binds CD28 (Homo sapiens)
REACT:R-MMU-2327733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 binds Collagen types I-V, VII (Mus musculus)
REACT:R-RNO-3234094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TFAP2C with SUMO1 (Rattus norvegicus)
REACT:R-CFA-193143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)
RHEA:49548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate
REACT:R-BTA-8875816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds activated MET receptor (Bos taurus)
REACT:R-XTR-2393954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)
GO:0102300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleate 9R-lipoxygenase activity
GO:0015126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	canalicular bile acid transmembrane transporter activity
REACT:R-SSC-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Sus scrofa)
REACT:R-SSC-6806629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tonofilament bundles (Sus scrofa)
REACT:R-DRE-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Danio rerio)
REACT:R-SCE-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Saccharomyces cerevisiae)
REACT:R-HSA-188025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Flagellin binds to TLR5 (Homo sapiens)
REACT:R-BTA-4551616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RPA1 (RPA70) with SUMO2,3 (Bos taurus)
RHEA:40679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-HSA-5657651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGMT binds alkylated DNA containing 6-O-methylguanine (Homo sapiens)
RHEA:48558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate => 4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)
REACT:R-DRE-418442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Danio rerio)
RHEA:50648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O
REACT:R-DRE-8938231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds CREBBP (Danio rerio)
REACT:R-CEL-445699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Caenorhabditis elegans)
RHEA:43998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate => 2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2
REACT:R-HSA-2395879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
RHEA:37586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine + H2O + O2 <=> 6-amino-2-oxohexanoate + H2O2 + NH4(+)
REACT:R-CFA-6799695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX5,6 reduce H2O2 to H2O (Canis familiaris)
RHEA:67450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + heptadecanal => (2R)-2-hydroxyoctadecanoyl-CoA
REACT:R-DRE-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Danio rerio)
REACT:R-CEL-70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Caenorhabditis elegans)
REACT:R-MMU-265153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Mus musculus)
REACT:R-BTA-380927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK phosphorylates TSC1:TSC2 (Bos taurus)
REACT:R-SSC-8869456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP4 deubiquitinate TRAF2,TRAF6 (Sus scrofa)
RHEA:38632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:59921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H2O + NAD(+) => (2E)-octenoate + 2 H(+) + NADH
REACT:R-HSA-9013631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD3 binds RBPJ and MAML in the nucleus (Homo sapiens)
REACT:R-XTR-8944246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXI (Xenopus tropicalis)
REACT:R-CFA-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Canis familiaris)
RHEA:12125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + shikimate => CoA + trans-4-coumaroylshikimate
REACT:R-DME-6791235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds AURKA (Drosophila melanogaster)
REACT:R-CFA-4641246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 autoubiquitinates to promote its internalization (Canis familiaris)
RHEA:50701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-377641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
GO:0017084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D1-pyrroline-5-carboxylate synthetase activity
GO:0017084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta1-pyrroline-5-carboxylate synthetase activity
RHEA:70477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + sphing-4-enine
EC:3.4.21.70	skos:prefLabel	"pancreatic endopeptidase E"
EC:3.4.21.70	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pancreatic endopeptidase E"
EC:3.4.21.70	skos:altLabel	"elastase III"
EC:3.4.21.70	skos:altLabel	"cholesterol-binding proteinase"
RHEA:58191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene + dimethylallyl diphosphate + H2O <=> dihydroisopentenyldehydrorhodopin + diphosphate
RHEA:61497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)
REACT:R-MMU-4341073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates PGR with SUMO1 (Mus musculus)
RHEA:30585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinone-8 + H2O + trimethylamine => 2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide
REACT:R-RNO-419646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:Met (Rattus norvegicus)
RHEA:60177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O => 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate
RHEA:24440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)
RHEA:24440	skos:altLabel	"ABC phosphate transporter"
RHEA:24440	skos:prefLabel	"ABC-type phosphate transporter"
RHEA:24440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type phosphate transporter"
RHEA:24440	skos:altLabel	"phosphate-transporting ATPase"
RHEA:23676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase"
RHEA:23676	skos:altLabel	"UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase"
RHEA:23676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
RHEA:23676	skos:altLabel	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase"
RHEA:23676	skos:prefLabel	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase"
RHEA:23676	skos:altLabel	"MurE synthetase"
RHEA:23676	skos:altLabel	"UDP-N-acetylmuramyl-tripeptide synthetase"
RHEA:23676	skos:altLabel	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming)"
REACT:R-CFA-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Canis familiaris)
RHEA:57186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + methylglyoxal
REACT:R-DRE-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Danio rerio)
RHEA:63653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-9697051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTC binds NRTIs (Homo sapiens)
REACT:R-CEL-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Caenorhabditis elegans)
REACT:R-CFA-265426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Tenascin (Canis familiaris)
REACT:R-CFA-8987096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)
REACT:R-DRE-201445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Danio rerio)
GO:0008801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-phosphoglucomutase activity
GO:0008801	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-glucose 1,6-phosphomutase activity
REACT:R-XTR-8855711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Xenopus tropicalis)
GO:0030745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity
GO:0030745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylhistidine methyltransferase activity
GO:0030745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylhistidine N-methyltransferase activity
GO:0030745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity
GO:0030745	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histidine-alpha-N-methyltransferase activity
RHEA:22105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + nicotianamine => 3''-deamino-3''-oxonicotianamine + L-glutamate
REACT:R-CEL-8855711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Caenorhabditis elegans)
RHEA:17299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA => 2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-1678742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses Heparan sulfate chain(4) (Drosophila melanogaster)
GO:0008957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetaldehyde dehydrogenase activity
GO:0008957	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylacetaldehyde:NAD+ oxidoreductase activity
REACT:R-BTA-198955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR complex interacts with peptide antigen-presenting MHC Class I (Bos taurus)
REACT:R-MMU-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Mus musculus)
REACT:R-MMU-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Mus musculus)
RHEA:27714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H2O = guanosine + phosphate
REACT:R-HSA-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Homo sapiens)
GO:0001883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine nucleoside binding
REACT:R-HSA-199404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40L binds CD40 (Homo sapiens)
REACT:R-XTR-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Xenopus tropicalis)
REACT:R-PFA-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Plasmodium falciparum)
REACT:R-DME-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Drosophila melanogaster)
REACT:R-BTA-5651723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Bos taurus)
REACT:R-GGA-2065355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)
EC:1.16.1.10	skos:prefLabel	"ferric-chelate reductase [NAD(P)H]"
EC:1.16.1.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferric-chelate reductase [NAD(P)H]"
EC:1.16.1.10	skos:altLabel	"ferric reductase"
REACT:R-DME-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Drosophila melanogaster)
RHEA:69494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + octanal => O2 + octan-1-ol
RHEA:69587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + inosine <=> guanosine + IMP
RHEA:45550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] => phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]
REACT:R-CEL-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Caenorhabditis elegans)
REACT:R-CFA-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Canis familiaris)
REACT:R-RNO-216045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I binds integrin alpha11beta1 (Rattus norvegicus)
RHEA:24883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) => H(+) + L-glutamate + NADPH
RHEA:53561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-419002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Xenopus tropicalis)
REACT:R-DME-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Drosophila melanogaster)
REACT:R-XTR-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Xenopus tropicalis)
REACT:R-RNO-173636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of classic pathway C5 convertase (Rattus norvegicus)
REACT:R-SSC-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Sus scrofa)
REACT:R-BTA-1638845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERK phosphorylates CERA to form C1P (Bos taurus)
REACT:R-MMU-2022405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)
RHEA:12893	skos:altLabel	"PGE isomerase"
RHEA:12893	skos:prefLabel	"prostaglandin-E synthase"
RHEA:12893	skos:altLabel	"prostaglandin-H2 E-isomerase"
RHEA:12893	skos:altLabel	"PGH-PGE isomerase"
RHEA:12893	skos:altLabel	"endoperoxide isomerase"
RHEA:12893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 = prostaglandin E2
RHEA:12893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prostaglandin-E synthase"
REACT:R-GGA-265301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticotropin cleavage from POMC (Gallus gallus)
RHEA:66200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pentanoyl-CoA = (2E)-pentenoyl-CoA + H2O2
REACT:R-DDI-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Dictyostelium discoideum)
RHEA:35172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + novobiocin(in) => H(+)(in) + novobiocin(out)
RHEA:16933	skos:prefLabel	"1-aminocyclopropane-1-carboxylate deaminase"
RHEA:16933	skos:altLabel	"ACC deaminase"
RHEA:16933	skos:altLabel	"1-aminocyclopropane carboxylic acid deaminase"
RHEA:16933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)
RHEA:16933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-aminocyclopropane-1-carboxylate deaminase"
RHEA:16933	skos:altLabel	"1-aminocyclopropane-1-carboxylate endolyase (deaminating)"
REACT:R-MMU-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Mus musculus)
REACT:R-DRE-6810410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)
REACT:R-DRE-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Danio rerio)
RHEA:50202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2
REACT:R-GGA-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Gallus gallus)
RHEA:45953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparaginyl-[protein] + UDP-alpha-D-glucose => H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP
EC:3.4.21.50	skos:prefLabel	"lysyl endopeptidase"
EC:3.4.21.50	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysyl endopeptidase"
EC:3.4.21.50	skos:altLabel	"Achromobacter proteinase I"
EC:3.4.21.50	skos:altLabel	"lysyl bond specific proteinase"
REACT:R-SSC-508247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
REACT:R-HSA-9609728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3B (GRIN3B) (Homo sapiens)
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	muscle phosphorylase
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	amylopectin phosphorylase
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-oligoglucan phosphorylase activity
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	potato phosphorylase
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	amylophosphorylase activity
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-glucan phosphorylase activity
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	starch phosphorylase
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-glucan phosphorylase
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myophosphorylase
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyphosphorylase activity
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	granulose phosphorylase
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glucosan phosphorylase
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glucan phosphorylase
GO:0004645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	muscle phosphorylase a and b activity
REACT:R-CFA-2059926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPHP4 protein binds LATS proteins (Canis familiaris)
REACT:R-CFA-8858298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRASLS transfer acyl group from PC to PE to form NAPE (Canis familiaris)
REACT:R-HSA-383373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 3 (NK3) binds to neurokinin B (Homo sapiens)
REACT:R-MMU-5656158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ elongates POLI-incorporated dNMP (Mus musculus)
REACT:R-SSC-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Sus scrofa)
RHEA:33133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + tetrahydrotyrosine => L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate
REACT:R-DRE-9759549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Danio rerio)
RHEA:35273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA
RHEA:70487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 = a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate
REACT:R-HSA-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)
REACT:R-CEL-2029475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of AA by iPLA2 upon FCGR activation (Caenorhabditis elegans)
EC:2.1.1.201	skos:prefLabel	"2-methoxy-6-polyprenyl-1,4-benzoquinol methylase"
EC:2.1.1.201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methoxy-6-polyprenyl-1,4-benzoquinol methylase"
REACT:R-RNO-9706393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds ATP (Rattus norvegicus)
REACT:R-MMU-202731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM3 dimerises (Mus musculus)
GO:0017130	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	poly(C) binding
GO:0017130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(rC) binding
GO:0017130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(C) RNA binding
REACT:R-SPO-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Schizosaccharomyces pombe)
REACT:R-BTA-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Bos taurus)
REACT:R-GGA-9714363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC translocates to the endoplasmic reticulum membrane (Gallus gallus)
REACT:R-DRE-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
REACT:R-HSA-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Homo sapiens)
REACT:R-HSA-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Homo sapiens)
REACT:R-CEL-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Caenorhabditis elegans)
REACT:R-PFA-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Plasmodium falciparum)
RHEA:39499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA = (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O
REACT:R-GGA-176250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR-ATRIP to the RPA-ssDNA complex (Gallus gallus)
RHEA:27701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-galactose + phosphate <=> beta-L-galactose 1-phosphate + GDP + H(+)
REACT:R-DRE-9638046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)
REACT:R-RNO-9009065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXA1 and GATA3 bind to CCND1 promoter (Rattus norvegicus)
RHEA:10115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + L-serine <=> H2O + L,L-cystathionine
RHEA:54308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine
REACT:R-XTR-380294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of C-Nap-1 from centrosomes (Xenopus tropicalis)
RHEA:37825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorophenol + CO2 + pyruvate + succinate => (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2
REACT:R-HSA-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Homo sapiens)
REACT:R-GGA-5618098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Gallus gallus)
REACT:R-MMU-2396370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds collagens II, III and V (Mus musculus)
RHEA:42410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + ADP + H(+) => (2R)-2-phosphoglycerate + ATP
REACT:R-DRE-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Danio rerio)
GO:0033431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGA codon-amino acid adaptor activity
GO:0033431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine tRNA
RHEA:10185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O => 3-oxoadipate + H(+)
REACT:R-CFA-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Canis familiaris)
REACT:R-RNO-2022403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)
RHEA:68057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O => a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)
RHEA:15589	skos:altLabel	"D-4-hydroxyphenylglycine aminotransferase"
RHEA:15589	skos:altLabel	"D-hydroxyphenylglycine aminotransferase"
RHEA:15589	skos:prefLabel	"D-4-hydroxyphenylglycine transaminase"
RHEA:15589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-4-hydroxyphenylglycine transaminase"
RHEA:15589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate
REACT:R-SCE-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Saccharomyces cerevisiae)
RHEA:38227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9Z)-octadecenoate
REACT:R-SSC-8875661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA3 associates with activated MET receptor (Sus scrofa)
REACT:R-CFA-429449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk activation leads to SLP-76 activation (Canis familiaris)
REACT:R-CFA-8849638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the SPINK5:KLK5 complex at low pH (Canis familiaris)
RHEA:36272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + theobromine
REACT:R-CFA-212614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamine transport from astrocytes (Canis familiaris)
GO:0008834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	undecaprenyl diphosphate synthetase activity
GO:0008834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bactoprenyl-diphosphate synthase activity
GO:0008834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity
GO:0008834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	di-trans,poly-cis-undecaprenyl-diphosphate synthase activity
GO:0008834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	undecaprenyl pyrophosphate synthetase activity
GO:0008834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	undecaprenyl-diphosphate synthase activity
GO:0008834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UPP synthetase activity
GO:0008834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	undecaprenyl pyrophosphate synthase activity
GO:0008834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,poly-cis-decaprenylcistransferase activity
GO:0008834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyl diphosphate synthase activity
REACT:R-CEL-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Caenorhabditis elegans)
REACT:R-CFA-2288097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Condensin II complex binds H4K20me1-containing nucleosomes (Canis familiaris)
REACT:R-MMU-8862137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B2 oxidises estradiol (E2) to estrone (E1) (Mus musculus)
GO:0031419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B12 binding
GO:0031419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalamin binding
REACT:R-GGA-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Gallus gallus)
RHEA:39567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-442387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP8 mediates zinc influx into cells (Bos taurus)
RHEA:36562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cis-4-hydroxy-D-proline <=> 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)
REACT:R-DME-209081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)
REACT:R-CFA-8950453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Canis familiaris)
REACT:R-RNO-168848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAK protein (Rattus norvegicus)
RHEA:65698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine
RHEA:23731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 <=> A + H2O + prostaglandin H2
RHEA:31824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => cubebol + diphosphate
REACT:R-HSA-5602316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MyD88 does not oligomerize within the complex of activated TLR5 (Homo sapiens)
REACT:R-XTR-163214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from reduced cytochrome c to molecular oxygen (Xenopus tropicalis)
RHEA:63056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine = 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine
REACT:R-BTA-265425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with von Willbrand Factor (Bos taurus)
GO:0047178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine
GO:0047178	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)
GO:0047178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophospholipid acyltransferase (CoA-dependent) activity
GO:0047178	skos:prefLabel	"glycerophospholipid acyltransferase (CoA-dependent)"
GO:0047178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerophospholipid acyltransferase (CoA-dependent)"
REACT:R-XTR-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Xenopus tropicalis)
RHEA:11296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate + H2O + NADP(+) = 2-oxoglutarate + 2 H(+) + NADPH
RHEA:11296	skos:prefLabel	"2,5-dioxovalerate dehydrogenase"
RHEA:11296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,5-dioxovalerate dehydrogenase"
RHEA:70141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-71324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)
RHEA:14191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formyl-D-kynurenine => D-tryptophan + O2
REACT:R-DDI-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Dictyostelium discoideum)
REACT:R-MMU-2530429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of soluble VTN:C5b-C9  (Mus musculus)
RHEA:21523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b1] + formate <=> CO2 + 2 Fe(II)-[cytochrome b1] + H(+)
RHEA:48202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA => H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA
RHEA:15048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) <=> (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH
REACT:R-CEL-1602377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Caenorhabditis elegans)
REACT:R-CEL-417842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 receptor can bind to LPA (Caenorhabditis elegans)
RHEA:31017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + indole => H(+) + indole-3-carboxylate
RHEA:42150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine
RHEA:27667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA
REACT:R-DDI-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Dictyostelium discoideum)
RHEA:66292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)
REACT:R-CFA-166726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MASPs (Canis familiaris)
REACT:R-DDI-1296035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Dictyostelium discoideum)
REACT:R-BTA-158722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Bos taurus)
REACT:R-DDI-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPMurNAc-L-alanine synthetase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramate-L-alanine ligase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramyl:L-alanine ligase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine-adding enzyme activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MurC synthetase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-acetylmuramyl-L-alanine synthetase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-MurNAc:L-alanine ligase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoylalanine synthetase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphospho-N-acetylmuramoylalanine synthetase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-Ala ligase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-adding enzyme activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanine synthetase activity
GO:0008763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate N-acetylmuramate:L-alanine ligase activity
REACT:R-GGA-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Gallus gallus)
RHEA:26426	skos:altLabel	"UTP--ammonia ligase"
RHEA:26426	skos:prefLabel	"CTP synthase (glutamine hydrolyzing)"
RHEA:26426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CTP synthase (glutamine hydrolyzing)"
RHEA:26426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate
RHEA:26426	skos:altLabel	"CTP synthetase"
RHEA:19290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sucrose 6(F)-phosphate => phosphate + sucrose
RHEA:19847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isonocardicin A + S-methyl-5'-thioadenosine => nocardicin E + S-adenosyl-L-methionine
GO:0015085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium ion transmembrane transporter activity
REACT:R-DME-8869568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM1 binds TFAP2A homodimer (Drosophila melanogaster)
RHEA:49162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Danio rerio)
RHEA:67668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-CEL-111285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)
REACT:R-XTR-158340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Xenopus tropicalis)
REACT:R-DRE-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Danio rerio)
RHEA:30010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-arabinose(out) <=> ADP + H(+) + L-arabinose(in) + phosphate
REACT:R-MMU-5638332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Mus musculus)
REACT:R-GGA-201640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Gallus gallus)
RHEA:55717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)
RHEA:59008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + salicylaldehyde = H(+) + H2O2 + salicylate
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytoskeletal protein-membrane adaptor activity
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	F-BAR domain adaptor
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal protein to membrane recruiting activity
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	membrane-cytoskeletal protein anchor activity
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytoskeletal protein membrane tether activity
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	BAR domain adaptor
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	microtubule cortical anchor activity
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	membrane-cytoskeletal protein tether activity
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal protein-membrane anchor activity
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytoskeletal protein membrane anchor activity
GO:0106006	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytoskeletal protein membrane adaptor
RHEA:33284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxycyclohexan-1-one + NADPH + O2 => 6-oxohexanoate + H2O + NADP(+)
REACT:R-XTR-982810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation (Xenopus tropicalis)
REACT:R-DME-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Drosophila melanogaster)
REACT:R-DME-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Drosophila melanogaster)
RHEA:55465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurochenodeoxycholate(out) => 2 Na(+)(in) + taurochenodeoxycholate(in)
REACT:R-DME-5671772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T38-PPP1R14A binds MLCP (Drosophila melanogaster)
REACT:R-DRE-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Danio rerio)
REACT:R-CEL-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Caenorhabditis elegans)
RHEA:19417	skos:prefLabel	"dolichyl-diphosphate--polyphosphate phosphotransferase"
RHEA:19417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-diphosphate--polyphosphate phosphotransferase"
RHEA:19417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + a dolichyl diphosphate = [phosphate](n+1) + a dolichyl phosphate
RHEA:49238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + sucrose 6(G)-phosphate(in) => N(pros)-phospho-L-histidyl-[protein](out) + sucrose
REACT:R-RNO-879930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 is recruited by JAK2 (Rattus norvegicus)
RHEA:43680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-DRE-389026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galanin receptors can bind galanin (Danio rerio)
RHEA:53378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NADP(+)
RHEA:23277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantoate => 3-methyl-2-oxobutanoate + formaldehyde
REACT:R-HSA-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Homo sapiens)
REACT:R-BTA-6804942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 homodimers auto-ubiquitinate (Bos taurus)
RHEA:59190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-histidine => L-histidine
RHEA:33644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoate + ATP + CoA => (9Z)-tetradecenoyl-CoA + AMP + diphosphate
REACT:R-GGA-202703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD47 binds SIRP (Gallus gallus)
RHEA:30649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-1L-myo-inositol + diphosphate => 1D-myo-inositol 3-phosphate + CTP + H(+)
REACT:R-GGA-9748996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers cleave AZA to 6MP (Gallus gallus)
REACT:R-DRE-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Danio rerio)
REACT:R-XTR-4615839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO2,3 (Xenopus tropicalis)
RHEA:46701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate + GTP + H(+) => (R)-lipoyl-GMP + diphosphate
REACT:R-HSA-2468041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Homo sapiens)
REACT:R-XTR-9011981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 is recruited to MYC and BCL2 genes (Xenopus tropicalis)
REACT:R-SSC-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Sus scrofa)
REACT:R-RNO-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Rattus norvegicus)
RHEA:33370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucose 6-phosphate(in) + L-histidyl-[protein]
RHEA:65506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O
REACT:R-CFA-71010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUT isomerises L-MM-CoA to SUCC-CoA (Canis familiaris)
RHEA:58091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O <=> (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)
RHEA:23485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-cellobiose => AH2 + D-cellobiono-1,5-lactone
REACT:R-DRE-5205663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)
RHEA:49040	skos:prefLabel	"5'-demethylyatein 5'-O-methyltransferase"
RHEA:49040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5'-demethylyatein 5'-O-methyltransferase"
RHEA:49040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-5'-demethylyatein + S-adenosyl-L-methionine = (-)-yatein + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-5334854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAR:RXR binds SUMO-CRABP2:atRA (Bos taurus)
GO:0005200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of cytoskeleton
RHEA:30367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate
REACT:R-HSA-193052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione isomerizes to progesterone (Homo sapiens)
REACT:R-HSA-984821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-12 is a dimer (Homo sapiens)
REACT:R-BTA-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Bos taurus)
REACT:R-HSA-5663132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds DBP gene (Homo sapiens)
REACT:R-CEL-8963864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN dissociates from 25(OH)D (Caenorhabditis elegans)
REACT:R-HSA-428205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [Golgi] (Homo sapiens)
REACT:R-RNO-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Rattus norvegicus)
REACT:R-CFA-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Canis familiaris)
REACT:R-DRE-442387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP8 mediates zinc influx into cells (Danio rerio)
RHEA:48254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b + H(+) + UDP => ganglioside GD2 + UDP-alpha-D-galactose
EC:1.14.13.63	skos:altLabel	"3-hydroxyphenylacetate 6-monooxygenase"
EC:1.14.13.63	skos:prefLabel	"3-hydroxyphenylacetate 6-hydroxylase"
EC:1.14.13.63	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxyphenylacetate 6-hydroxylase"
RHEA:28638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphate
RHEA:33137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(out) + Na(+)(out) => malonate(in) + Na(+)(in)
RHEA:61361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + pheophorbide a(in) => ADP + H(+) + pheophorbide a(out) + phosphate
GO:0008934	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	myo-inositol-1(or 4)-monophosphatase activity
GO:0008934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol monophosphate 1-phosphatase activity
GO:0008934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol-1-phosphatase activity
GO:0008934	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	myo-inositol-1(or 4)-phosphate phosphohydrolase activity
GO:0008934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-myo-inositol-1-phosphate phosphatase activity
GO:0008934	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol-1(or 4)-monophosphatase activity
GO:0008934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol 1-phosphatase activity
GO:0008934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol 1-phosphatase activity
RHEA:43040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + hexadecasphinganine = CoA + H(+) + N-hexadecanoylhexadecasphinganine
REACT:R-XTR-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)
REACT:R-SPO-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Schizosaccharomyces pombe)
REACT:R-HSA-9640063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ binds KCNIP3 (Homo sapiens)
EC:3.4.22.31	skos:prefLabel	"ananain"
EC:3.4.22.31	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ananain"
REACT:R-DME-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Drosophila melanogaster)
RHEA:38166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
RHEA:15962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxymandelonitrile + UDP-alpha-D-glucose => H(+) + taxiphyllin + UDP
EC:3.1.12.-	skos:prefLabel	"Exodeoxyribonucleases producing 3'-phosphomonoesters"
EC:3.1.12.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Exodeoxyribonucleases producing 3'-phosphomonoesters"
REACT:R-GGA-158354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Gallus gallus)
REACT:R-CEL-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Caenorhabditis elegans)
RHEA:25983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)
RHEA:46515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:68398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + H(+) + H2O2 => a percarboxylic acid + H2O
RHEA:46851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADPH
REACT:R-CFA-159843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)
REACT:R-BTA-73739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Bos taurus)
RHEA:66151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + acetyl-CoA <=> CoA + H(+) + N-(2-phenylethyl)acetamide
GO:0052919	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(R)-HNL activity
GO:0052919	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(R)-hydroxynitrile lyase activity
GO:0052919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aliphatic (R)-hydroxynitrile lyase activity
GO:0052919	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(R)-oxynitrilase activity
REACT:R-DME-5340195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4 binds DCA, CDCA, LCHA (Drosophila melanogaster)
RHEA:70323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxo-L-gulonate = 2-carboxy-L-lyxonolactone
RHEA:64742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine
RHEA:20357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + H(+) + NADH + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)
GO:0008187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly-pyrimidine tract binding
REACT:R-BTA-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Bos taurus)
REACT:R-DDI-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Dictyostelium discoideum)
REACT:R-RNO-2002440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen C-propeptides (Rattus norvegicus)
RHEA:27860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-GMP + H(+) => 2',3'-cyclophospho-GMP + H2O
REACT:R-CFA-5655466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Canis familiaris)
RHEA:14822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-arabinopyranose => L-ribulose
RHEA:70073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + sitosterol
REACT:R-GGA-5357845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is deubiquitinated (Gallus gallus)
RHEA:24870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + adenine
RHEA:18458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)
REACT:R-MMU-5687484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Mus musculus)
REACT:R-RNO-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Rattus norvegicus)
RHEA:35707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-versicolorone + H(+) + NADPH + O2 = (3S)-versiconol acetate + H2O + NADP(+)
REACT:R-MMU-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)
REACT:R-HSA-9621032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1 binds the TPH1 promoter (Homo sapiens)
REACT:R-CEL-8948066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-IRAK1 dissociates (Caenorhabditis elegans)
REACT:R-CEL-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Caenorhabditis elegans)
RHEA:54279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartyl-[protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate
RHEA:38325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + glycerol => 2 1-(9Z-octadecenoyl)-glycerol
RHEA:53104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-8952996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 forms homodimers (Rattus norvegicus)
REACT:R-DRE-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Danio rerio)
REACT:R-SSC-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Sus scrofa)
RHEA:48137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + H2O => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate
REACT:R-SSC-5684868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPC translocates from ER membrane to multivesicle body (Sus scrofa)
REACT:R-RNO-9027043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYPs hydroxylate DHA to 14(R)-HDHA (Rattus norvegicus)
RHEA:45417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O => 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)
RHEA:16998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol => 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-166284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
GO:0008480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sarcosine:acceptor oxidoreductase (demethylating)
GO:0008480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sarcosine N-demethylase activity
GO:0008480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sarcosine dehydrogenase activity
GO:0008480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monomethylglycine dehydrogenase activity
GO:0008480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sarcosine:(acceptor) oxidoreductase (demethylating)
REACT:R-MMU-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Mus musculus)
RHEA:57271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP <=> GMP + H(+) + lactate
RHEA:17561	skos:altLabel	"choline esterase I"
RHEA:17561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine + H2O = acetate + choline + H(+)
RHEA:17561	skos:altLabel	"cholinesterase"
RHEA:17561	skos:altLabel	"true cholinesterase"
RHEA:17561	skos:prefLabel	"acetylcholinesterase"
RHEA:17561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylcholinesterase"
RHEA:55561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxyeicosatetraenoate => a hydroxy-epoxy-eicosatetraenoate
RHEA:47321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate => 3-oxo-3-phenylpropanoate + L-glutamate
RHEA:50788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH
RHEA:47399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanoate ester <=> an aliphatic alcohol + H(+) + octadecanoate
RHEA:69311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> phenylacetonitrile + sulfate + sulfur
REACT:R-SCE-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Saccharomyces cerevisiae)
RHEA:24009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hypotaurocyamine => ADP + H(+) + N(omega)-phosphohypotaurocyamine
GO:1990404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-protein ADP-ribosyltransferase activity
GO:1990404	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein ADP-ribosyltransferase activity
GO:1990404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein ADP-ribosylase activity
GO:1990404	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribosylase activity
REACT:R-HSA-9757578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDN (Homo sapiens)
RHEA:65942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-glucose
REACT:R-MMU-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)
REACT:R-BTA-5672961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates inactive RAFs (Bos taurus)
REACT:R-HSA-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Homo sapiens)
GO:0102637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate-CoA ligase activity
REACT:R-CFA-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Canis familiaris)
REACT:R-MMU-193981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 oxidises 17HPROG (Mus musculus)
RHEA:44049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
REACT:R-HSA-5205661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)
REACT:R-HSA-3640874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
REACT:R-CEL-5685953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)
REACT:R-MMU-6786789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer binds FLT3 (Mus musculus)
REACT:R-DRE-3858482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is recruited to the receptor (Danio rerio)
RHEA:47274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisanhydrobacterioruberin + H2O => monoanhydrobacterioruberin
REACT:R-DME-2028644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Drosophila melanogaster)
REACT:R-RNO-5578966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A:AGO2:miRNA is transported into the nucleus (Rattus norvegicus)
REACT:R-MMU-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Mus musculus)
RHEA:32130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-proline + O2 <=> cis-4-hydroxy-L-proline + CO2 + succinate
REACT:R-PFA-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Plasmodium falciparum)
REACT:R-RNO-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Rattus norvegicus)
REACT:R-CFA-111915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK4 autophosphorylates (Canis familiaris)
REACT:R-DRE-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Danio rerio)
RHEA:69413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + tert-butyl hydroperoxide => glutathione disulfide + H2O + tert-butanol
RHEA:39248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z)-eicosenoyl-CoA => (2E,11Z)-eicosadienoyl-CoA + H2O
REACT:R-RNO-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Rattus norvegicus)
RHEA:31559	skos:altLabel	"L-galactose dehydrogenase"
RHEA:31559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-galactose 1-dehydrogenase"
RHEA:31559	skos:prefLabel	"L-galactose 1-dehydrogenase"
RHEA:31559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactose + NAD(+) = H(+) + L-galactono-1,4-lactone + NADH
RHEA:31559	skos:altLabel	"L-GalDH"
REACT:R-BTA-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Bos taurus)
GO:0031758	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Edg-5 sphingosine 1-phosphate receptor ligand
GO:0031758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edg-5 sphingosine 1-phosphate receptor binding
RHEA:10213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 5-aminopentanoate => 5-oxopentanoate + L-glutamate
GO:0051063	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP reduction
GO:0051063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP reductase activity
RHEA:58926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-maackiain + H2O => (3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol
REACT:R-BTA-2424243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Bos taurus)
REACT:R-HSA-8866308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL translocates from RER membrane to SER lumen (Homo sapiens)
REACT:R-XTR-9009065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXA1 and GATA3 bind to CCND1 promoter (Xenopus tropicalis)
REACT:R-MMU-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Mus musculus)
GO:0038046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-opioid receptor activity
GO:0038046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled enkephalin receptor activity
GO:0038046	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	enkephalin receptor activity
REACT:R-SSC-8953037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F8 forms homodimers (Sus scrofa)
REACT:R-BTA-177922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR dimerization (Bos taurus)
REACT:R-XTR-193452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Xenopus tropicalis)
REACT:R-CFA-6782820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates SUDS3 (Canis familiaris)
REACT:R-CFA-927813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
RHEA:10661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] => D-seryl-[protein]
REACT:R-SSC-446877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is K63 poly-ubiquitinated (Sus scrofa)
RHEA:56995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> (+)-costunolide + H2O
RHEA:71727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + fumarate(in) = citrate(in) + fumarate(out)
RHEA:16477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADH
RHEA:62738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate
RHEA:28174	skos:altLabel	"9-DES"
RHEA:28174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = colneleate + H2O
RHEA:28174	skos:prefLabel	"colneleate synthase"
RHEA:28174	skos:altLabel	"CYP74D"
RHEA:28174	skos:altLabel	"CYP74D1"
RHEA:28174	skos:altLabel	"9-divinyl ether synthase"
RHEA:28174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"colneleate synthase"
RHEA:28174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate = colnelenate + H2O
EC:2.4.99.15	skos:altLabel	"3-deoxy-D-manno-oct-2-ulosonic acid transferase"
EC:2.4.99.15	skos:prefLabel	"(Kdo)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase"
EC:2.4.99.15	skos:altLabel	"Kdo transferase"
EC:2.4.99.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(Kdo)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase"
EC:2.4.99.15	skos:altLabel	"3-deoxy-manno-octulosonic acid transferase"
RHEA:20512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + viomycin <=> ADP + H(+) + O-phosphoviomycin
REACT:R-MMU-8858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF9 binds TNFRSF9 (Mus musculus)
REACT:R-GGA-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Gallus gallus)
RHEA:23527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol <=> an alkyl cinnamate + beta-D-glucose
RHEA:47587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GT1c (d18:1(4E)) + H(+) + UDP
GO:0046820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-aminobenzoate synthetase
GO:0046820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminodeoxychorismate synthase"
GO:0046820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminodeoxychorismate synthase activity
GO:0046820	skos:altLabel	"4-amino-4-deoxychorismate synthase"
GO:0046820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
GO:0046820	skos:prefLabel	"aminodeoxychorismate synthase"
GO:0046820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PabB activity
GO:0046820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chorismate:L-glutamine amido-ligase activity
GO:0046820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADC synthase activity
GO:0046820	skos:altLabel	"ADC synthase"
GO:0046820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate synthase activity
GO:0046820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	para-aminobenzoic acid (PABA) synthase
GO:0046820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	para-aminobenzoic acid synthase activity
REACT:R-SCE-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Saccharomyces cerevisiae)
REACT:R-HSA-5617859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retinoic acid activates HOXB4 chromatin (Homo sapiens)
RHEA:61423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol <=> cis-cis-nepetalactol
REACT:R-BTA-5638141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Bos taurus)
GO:0033773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP81E1
GO:0033773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoflavone 2'-hydroxylase activity
GO:0033773	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isoflavone 2'-monooxygenase activity
GO:0033773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP Ge-3
REACT:R-SSC-1602377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Sus scrofa)
GO:0001614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purinergic receptor activity
GO:0001614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purinoreceptor
GO:0001614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purinergic nucleotide receptor activity
GO:0001614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purinoceptor
GO:0001614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P2 receptor
REACT:R-RNO-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Rattus norvegicus)
RHEA:28781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + glycolaldehyde => 4-hydroxy-L-threonine
REACT:R-CFA-448427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 binds Interleukin-27 receptor (Canis familiaris)
REACT:R-CFA-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Canis familiaris)
REACT:R-BTA-5682802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI3 binds ADAM22,23,synatxin1 (Bos taurus)
RHEA:30614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-zeta-carotene <=> AH2 + all-trans-neurosporene
RHEA:16132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pyridoxine <=> H(+) + NADPH + pyridoxal
REACT:R-HSA-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Homo sapiens)
REACT:R-BTA-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Bos taurus)
RHEA:58148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethyl acetate hydrolase"
RHEA:58148	skos:prefLabel	"ethyl acetate hydrolase"
RHEA:58148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl acetate + H2O = acetate + ethanol + H(+)
REACT:R-SCE-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Saccharomyces cerevisiae)
RHEA:57353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin => H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-165043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)
REACT:R-MMU-200143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates AKT1S1 (PRAS40) (Mus musculus)
GO:0008709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate 7-alpha-dehydrogenase activity
GO:0008709	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	7-alpha-hydroxysteroid dehydrogenase activity
GO:0008709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7alpha-HSDH
GO:0008709	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	7alpha-hydroxy steroid dehydrogenase activity
GO:0008709	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	7alpha-hydroxysteroid dehydrogenase activity
GO:0008709	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity
REACT:R-MMU-443831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3-zeta binds Raf1 (Mus musculus)
RHEA:23716	skos:altLabel	"acetylene-allene isomerase"
RHEA:23716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA
RHEA:23716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Delta(3)-Delta(2)-enoyl-CoA isomerase"
RHEA:23716	skos:altLabel	"Delta(3),Delta(2)-enoyl-CoA isomerase"
RHEA:23716	skos:altLabel	"Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase"
RHEA:23716	skos:prefLabel	"Delta(3)-Delta(2)-enoyl-CoA isomerase"
RHEA:23716	skos:altLabel	"dodecenoyl-CoA Delta-isomerase"
RHEA:23716	skos:altLabel	"dodecenoyl-CoA isomerase"
RHEA:23716	skos:altLabel	"3,2-trans-enoyl-CoA isomerase"
RHEA:67191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) <=> ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate
RHEA:47573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) => CMP + ganglioside GT1b (d18:1(4E)) + H(+)
REACT:R-CEL-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-BTA-192054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Bos taurus)
REACT:R-DME-77593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage and polyadenylation of Intronless Pre-mRNA (Drosophila melanogaster)
REACT:R-XTR-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Xenopus tropicalis)
RHEA:33480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + lanosterol => CoA + lanosteryl ester
REACT:R-MMU-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Mus musculus)
RHEA:51987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:39259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z)-docosenoyl-CoA = (2E,13Z)-docosadienoyl-CoA + H2O
REACT:R-XTR-9667619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B,2 bind atosiban (Xenopus tropicalis)
GO:0042556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eEF-2 kinase regulator
GO:0042556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eukaryotic elongation factor-2 kinase regulator activity
REACT:R-BTA-8851352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR8 binds CCL1 (Bos taurus)
RHEA:17581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O = an L-alpha-amino acid + CO2 + NH4(+)
RHEA:17581	skos:altLabel	"L-carbamoylase"
RHEA:17581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-carbamoyl-L-amino-acid hydrolase"
RHEA:17581	skos:altLabel	"N-carbamoylase"
RHEA:17581	skos:altLabel	"L-N-carbamoylase"
RHEA:17581	skos:prefLabel	"N-carbamoyl-L-amino-acid hydrolase"
RHEA:17581	skos:altLabel	"N-carbamoyl-L-amino acid amidohydrolase"
RHEA:17581	skos:altLabel	"N-carbamoyl L-amino acid amidohydrolase"
RHEA:43629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NAD(+) => aminoacetaldehyde + CO2 + NADH
RHEA:35849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + sphing-4-enine 1-phosphate => ATP + sphing-4-enine
REACT:R-HSA-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Homo sapiens)
RHEA:21776	skos:altLabel	"DHCA-CoA ligase"
RHEA:21776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate
RHEA:21776	skos:prefLabel	"3alpha,7alpha-dihydroxy-5beta-cholestanate--CoA ligase"
RHEA:21776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha,7alpha-dihydroxy-5beta-cholestanate--CoA ligase"
REACT:R-DRE-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Danio rerio)
REACT:R-DRE-71324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)
REACT:R-BTA-8858346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMHR2 binds AMH (Bos taurus)
REACT:R-GGA-3229102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPKAPK3 phosphorylates BMI1 (Gallus gallus)
REACT:R-SPO-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Schizosaccharomyces pombe)
REACT:R-BTA-351877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 2 (Bos taurus)
REACT:R-BTA-9793679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)
REACT:R-XTR-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Xenopus tropicalis)
RHEA:25468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = beta-himachalene + diphosphate
REACT:R-DRE-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Danio rerio)
REACT:R-RNO-1678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses CS/HS precursor (Rattus norvegicus)
REACT:R-HSA-9024872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 17(S)-Hp-DHA to PDX (Homo sapiens)
RHEA:12135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Cd(2+)(in) + H2O <=> ADP + Cd(2+)(out) + H(+) + phosphate
GO:0018668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate 4-monooxygenase activity
GO:0018668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate 4-hydroxylase activity
GO:0018668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)
GO:0018668	skos:prefLabel	"3-hydroxybenzoate 4-monooxygenase"
GO:0018668	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)
GO:0018668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybenzoate 4-monooxygenase"
GO:0018668	skos:altLabel	"3-hydroxybenzoate 4-hydroxylase"
RHEA:60233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate
RHEA:44097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decan-1-ol + hexadecanoyl-CoA => CoA + decanyl hexadecanoate
REACT:R-CEL-8848758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates AKT1 (Caenorhabditis elegans)
GO:1990935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	splicing factor binding
RHEA:40138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + H2O <=> (9Z)-tetradecenoate + CoA + H(+)
REACT:R-HSA-5693574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Homo sapiens)
RHEA:61165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + UDP-beta-L-rhamnose => H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP
RHEA:50180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate
REACT:R-HSA-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Homo sapiens)
REACT:R-MMU-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Mus musculus)
REACT:R-HSA-8858500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC10A binds Tn-MUC1 (Homo sapiens)
REACT:R-HSA-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Homo sapiens)
REACT:R-CEL-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Caenorhabditis elegans)
REACT:R-CFA-390886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH4 binds Hist (Canis familiaris)
RHEA:30985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]
REACT:R-CEL-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Caenorhabditis elegans)
RHEA:41889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)
RHEA:55289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetradecan-1-ol + tetradecanoyl-CoA => CoA + tetradecanyl tetradecanoate
RHEA:47086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-tyrosine
REACT:R-HSA-398040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma activation of PLC beta (Homo sapiens)
RHEA:30951	skos:prefLabel	"alpha-eudesmol synthase"
RHEA:30951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-eudesmol synthase"
RHEA:30951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = alpha-eudesmol + diphosphate
REACT:R-GGA-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Gallus gallus)
REACT:R-SSC-428518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glypican-1 (GPC1) binds SLIT2 (Sus scrofa)
REACT:R-XTR-5694433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 binds PREB (Xenopus tropicalis)
REACT:R-DRE-141026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor Va to factor Vi intermediate form (Danio rerio)
GO:0033766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity
GO:0033766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-1,2-dihydroquinoline 8-monooxygenase activity
GO:0033766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyquinoline 8-monooxygenase activity
RHEA:66349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A => (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2
REACT:R-GGA-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)
REACT:R-RNO-5656158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ elongates POLI-incorporated dNMP (Rattus norvegicus)
RHEA:51331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate
RHEA:49340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:18743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetylbaccatin III + CoA => 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA
RHEA:46131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:37820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:61327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-5334794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABPs bind LCFAs (Drosophila melanogaster)
REACT:R-DRE-4420140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Danio rerio)
REACT:R-DRE-2395872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)
RHEA:34039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + neamine = 6'-oxoparomamine + L-glutamate
RHEA:34039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neamine transaminase"
RHEA:34039	skos:altLabel	"glutamate--6'-dehydroparomamine aminotransferase"
RHEA:34039	skos:prefLabel	"neamine transaminase"
GO:0043027	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	caspase inhibitor activity
GO:0043027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
RHEA:43630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetaldehyde + CO2 + NADH => L-serine + NAD(+)
REACT:R-HSA-419002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Homo sapiens)
GO:0052615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaurene oxidase activity
REACT:R-DRE-375151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with collagens (Danio rerio)
REACT:R-HSA-9725342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM-ALK-dependent JUNB gene transcription (Homo sapiens)
REACT:R-GGA-372422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + NADH + H+ <=> malate + NAD+ (Gallus gallus)
RHEA:63171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + L-cysteine <=> S-(2-succino)-L-cysteine
RHEA:36195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)
RHEA:39735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Bos taurus)
REACT:R-BTA-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Bos taurus)
REACT:R-SSC-5684887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of CHEK1 at resected DNA DSBs (Sus scrofa)
REACT:R-SSC-6806613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin tetramers bind to form unit length filaments (Sus scrofa)
REACT:R-SSC-1433456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs (Sus scrofa)
GO:0005360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	insulin-responsive hydrogen:glucose transporter activity
GO:0005360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin-responsive hydrogen:glucose symporter activity
GO:0005360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin-responsive glucose:proton symporter activity
GO:0005360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transepithelial hydrogen/glucose transporter activity
RHEA:48069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)) + H2O => ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate
REACT:R-HSA-389759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)
REACT:R-DRE-201712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin:TCF associates with BCL9 and PYGO (Danio rerio)
RHEA:35434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> cyanidin 3,7-di-O-beta-D-glucoside + vanillate
REACT:R-SCE-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Saccharomyces cerevisiae)
EC:1.5.1.21	skos:altLabel	"Pyr2C reductase"
EC:1.5.1.21	skos:prefLabel	"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)"
EC:1.5.1.21	skos:altLabel	"Delta(1)-piperideine-2-carboxylate reductase"
EC:1.5.1.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)"
REACT:R-SSC-8938217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SWI/SNF complex (Sus scrofa)
REACT:R-BTA-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)
REACT:R-MMU-5665802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Mus musculus)
REACT:R-MMU-8865613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Mus musculus)
RHEA:14485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = 10-epi-juneol + diphosphate
RHEA:14485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"10-epi-juneol synthase"
RHEA:14485	skos:prefLabel	"10-epi-juneol synthase"
REACT:R-DME-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Drosophila melanogaster)
REACT:R-CEL-77592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Intronless Pre-mRNA at 3'-end (Caenorhabditis elegans)
RHEA:61667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + ATP <=> (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)
REACT:R-DME-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Drosophila melanogaster)
REACT:R-HSA-5660706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:61447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tetracycline + H(+) + NADPH + O2 <=> an 11a-hydroxytetracycline + H2O + NADP(+)
REACT:R-DRE-622325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)
REACT:R-HSA-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Homo sapiens)
GO:0050648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding
GO:0050648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
RHEA:63424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate
RHEA:63424	skos:prefLabel	"2-phospho-L-lactate guanylyltransferase"
RHEA:63424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-phospho-L-lactate guanylyltransferase"
RHEA:50578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein]
REACT:R-XTR-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Xenopus tropicalis)
REACT:R-RNO-391943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLT2 binds LTC4,LTD4,LTE4 (Rattus norvegicus)
RHEA:63501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + S-nitrosoglutathione => NADP(+) + sulfinamide glutathione
REACT:R-DME-9634834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACHEIs bind ACHE (Drosophila melanogaster)
RHEA:36878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA
RHEA:59950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha-CoA
REACT:R-HSA-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Homo sapiens)
RHEA:18884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + histamine + L-glutamate <=> ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate
REACT:R-CFA-914012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Canis familiaris)
REACT:R-RNO-1861621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIA with IgG-coated Ag (Rattus norvegicus)
REACT:R-CFA-70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Canis familiaris)
REACT:R-HSA-8847968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN binds FRK (Homo sapiens)
REACT:R-DRE-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Danio rerio)
REACT:R-SCE-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Saccharomyces cerevisiae)
REACT:R-BTA-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)
GO:0140338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingomyelin carrier activity
GO:0140338	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sphingosine transmembrane transporter activity
GO:0140338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingomyelin transfer activity
RHEA:45872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-SCE-428262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Saccharomyces cerevisiae)
REACT:R-DRE-6804724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates phosphorylated MDM4 (Danio rerio)
RHEA:24966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitetrol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-DRE-187545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cks1 with SCF(Skp2) complex (Danio rerio)
REACT:R-MMU-421007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of Ca impermeable AMPA receptors (Mus musculus)
RHEA:64673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(methylsulfanyl)acetyl-CoA + butan-1-ol => butyl 2-(methylsulfanyl)acetate + CoA
REACT:R-SSC-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Sus scrofa)
RHEA:63635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-AMP + holo-[ACP] <=> a long-chain fatty acyl-[ACP] + AMP + H(+)
RHEA:51663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 <=> an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)
GO:0102236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hexen-3-one reductase activity
REACT:R-DRE-417858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y14 receptor can bind to UDP-glucose (Danio rerio)
RHEA:36288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NADP(+)
REACT:R-CFA-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Canis familiaris)
REACT:R-GGA-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Gallus gallus)
RHEA:11464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + L,L-homocystine = glutathione disulfide + 2 L-homocysteine
RHEA:11464	skos:prefLabel	"glutathione--homocystine transhydrogenase"
RHEA:11464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione--homocystine transhydrogenase"
RHEA:53969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[BtrI ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]
RHEA:34948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-aminoacrylate + H(+) + H2O => 3-oxopropanoate + NH4(+)
RHEA:44298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA
GO:0015493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine:hydrogen symporter activity
GO:0015493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine:proton symporter activity
RHEA:39977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + NH4(+) => 2-iminobutanoate + H2O
REACT:R-GGA-4088130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds FOXM1 (Gallus gallus)
REACT:R-PFA-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Plasmodium falciparum)
GO:0062156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial ATP-gated potassium channel activity
GO:0062156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitoK-ATP activity
GO:0062156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial potassium channel activity
RHEA:32739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-5607758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC7A binds 1,3-beta-D-glucan (Homo sapiens)
RHEA:62618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+) => a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose
REACT:R-RNO-400509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Rattus norvegicus)
REACT:R-DME-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Drosophila melanogaster)
RHEA:47535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NAD(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
REACT:R-SSC-159729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)
RHEA:58182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopaoctaene + diphosphate + NADP(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH
REACT:R-XTR-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Xenopus tropicalis)
REACT:R-RNO-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Rattus norvegicus)
REACT:R-SCE-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)
REACT:R-MMU-430347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MigFilin associates with Filamin and F-actin (Mus musculus)
REACT:R-MMU-2187358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters unphosphorylated SMAD2/3 (Mus musculus)
REACT:R-HSA-2990880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)
RHEA:10340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-vetispiradiene + diphosphate
RHEA:10340	skos:altLabel	"HVS"
RHEA:10340	skos:prefLabel	"vetispiradiene synthase"
RHEA:10340	skos:altLabel	"vetispiradiene-forming farnesyl pyrophosphate cyclase"
RHEA:10340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vetispiradiene synthase"
RHEA:10340	skos:altLabel	"vetispiradiene cyclase"
RHEA:10340	skos:altLabel	"pemnaspirodiene synthase"
REACT:R-MMU-174121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Securin with Cdc20:APC/C complex (Mus musculus)
RHEA:39707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA(out) = a long-chain fatty acyl-CoA(in)
RHEA:57791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite
REACT:R-BTA-8944225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVII (Bos taurus)
RHEA:67101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumigatonoid B => fumigatonoid C
REACT:R-SSC-9029551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Sus scrofa)
REACT:R-RNO-3296126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Rattus norvegicus)
REACT:R-SSC-9667563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR2 bind desmopressin (Sus scrofa)
REACT:R-CEL-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Caenorhabditis elegans)
RHEA:41973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) => CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)
RHEA:33504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + itraconazole(in) => ADP + H(+) + itraconazole(out) + phosphate
RHEA:19159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-arabinonate + H2O => D-xylonate
REACT:R-GGA-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Gallus gallus)
REACT:R-MMU-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Mus musculus)
RHEA:12560	skos:altLabel	"arbutin synthase"
RHEA:12560	skos:altLabel	"hydroquinone:O-glucosyltransferase"
RHEA:12560	skos:prefLabel	"hydroquinone glucosyltransferase"
RHEA:12560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroquinone glucosyltransferase"
RHEA:12560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone + UDP-alpha-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP
RHEA:63342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-seryl-[protein]
REACT:R-SSC-9029561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to the ABCA1 promoter (Sus scrofa)
REACT:R-XTR-5218952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Xenopus tropicalis)
REACT:R-CFA-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Canis familiaris)
RHEA:14924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + UDP-alpha-D-glucose <=> 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP
RHEA:24025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
REACT:R-HSA-2534359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CatSper Channel Mediated Calcium Transport (Homo sapiens)
RHEA:61557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-5658435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs bind RAS:GTP (Mus musculus)
RHEA:11971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + kynurenate + O2 <=> 7,8-dihydro-7,8-dihydroxykynurenate + A
REACT:R-GGA-167408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The high affinity receptor complex binds to G-protein (Gallus gallus)
REACT:R-SSC-9027302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Sus scrofa)
RHEA:39341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH
RHEA:34103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase"
RHEA:34103	skos:prefLabel	"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase"
RHEA:34103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:34103	skos:altLabel	"GlcNAc-P-P-Und 4-epimerase"
GO:0002950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Homo sapiens)
GO:0002950	skos:prefLabel	"ceramide phosphoethanolamine synthase"
GO:0002950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ceramide phosphoethanolamine synthase"
GO:0002950	skos:altLabel	"CPE synthase"
GO:0002950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide phosphoethanolamine synthase activity
GO:0034610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligodeoxyribonucleotidase activity
GO:0034610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA oligonucleotidase activity
RHEA:38491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)
RHEA:37648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-HSA-2984220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1:CCNB phosphorylates NEK9 (Homo sapiens)
REACT:R-CEL-1592349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14 (MT1-MMP) binds TIMP2 (Caenorhabditis elegans)
REACT:R-DME-8941613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)
RHEA:36671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z)-hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine
REACT:R-SSC-5654514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds FGFR1c (Sus scrofa)
REACT:R-GGA-1602458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP10 (Gallus gallus)
REACT:R-MMU-9727188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B binds PPIs (Mus musculus)
REACT:R-CFA-9647680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP1 cleaves GSDMD (Canis familiaris)
RHEA:38721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + ADP + H(+) + phosphate => (R)-carnitine(out) + ATP + H2O
REACT:R-DME-73805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Drosophila melanogaster)
RHEA:31357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + methanethiol + NAD(+) => dimethyl sulfide + H(+) + NADH + O2
RHEA:51872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + umbelliferone = diphosphate + osthenol
RHEA:70021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + typhasterol
REACT:R-DDI-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Dictyostelium discoideum)
RHEA:50043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
RHEA:49950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2
REACT:R-BTA-193070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)
RHEA:22786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphoenolpyruvate + sulfite => (2R)-O-phospho-3-sulfolactate
GO:0052872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tocotrienol omega-hydroxylase activity
GO:0052872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tocotrienol 13-hydroxylase activity
REACT:R-DRE-170087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Danio rerio)
REACT:R-RNO-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Rattus norvegicus)
GO:0103045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methione N-acyltransferase activity
RHEA:15794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin IXalpha + NADP(+) => biliverdin IXalpha + H(+) + NADPH
RHEA:58500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + H(+) + NADH + O2 = glyoxylate + H2O + NAD(+) + trimethylamine
RHEA:24292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate
RHEA:24292	skos:prefLabel	"amino-acid N-acetyltransferase"
RHEA:24292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amino-acid N-acetyltransferase"
RHEA:24292	skos:altLabel	"N-acetylglutamate synthase"
RHEA:60461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
RHEA:70273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate
REACT:R-CFA-8931648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Canis familiaris)
RHEA:25595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2 => 2-oxoglutarate + H(+) + isochorismate
RHEA:51815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)
REACT:R-SSC-190245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1b binds to FGF (Sus scrofa)
GO:0052827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol pentakisphosphate phosphatase activity
REACT:R-PFA-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Plasmodium falciparum)
REACT:R-SSC-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Sus scrofa)
REACT:R-HSA-3318413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Homo sapiens)
RHEA:24905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-GMP + H2O <=> 5'-phosphoguanylyl(3'->5')guanosine + H(+)
RHEA:40905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-RNO-9009817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acitretin binds to RAR:RXR (Rattus norvegicus)
REACT:R-BTA-166795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Classical C3 convertase (C4b:C2a complex) (Bos taurus)
REACT:R-DME-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Drosophila melanogaster)
RHEA:21976	skos:altLabel	"thioredoxin-dependent 5'-adenylylsulfate reductase"
RHEA:21976	skos:prefLabel	"adenylyl-sulfate reductase (thioredoxin)"
RHEA:21976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate
RHEA:21976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylyl-sulfate reductase (thioredoxin)"
REACT:R-SSC-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Sus scrofa)
REACT:R-SSC-202722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD48 binds CD244 (Sus scrofa)
REACT:R-CEL-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)
REACT:R-RNO-8986995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Rattus norvegicus)
RHEA:55310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate
REACT:R-SPO-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Schizosaccharomyces pombe)
REACT:R-HSA-389762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PD-1 (Homo sapiens)
RHEA:12617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylgalactosamine kinase"
RHEA:12617	skos:altLabel	"N-acetylgalactosamine (GalNAc)-1-phosphate kinase"
RHEA:12617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-alpha-D-galactosamine = ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate
RHEA:12617	skos:altLabel	"GalNAc kinase"
RHEA:12617	skos:altLabel	"GALK2"
RHEA:12617	skos:altLabel	"GK2"
RHEA:12617	skos:prefLabel	"N-acetylgalactosamine kinase"
REACT:R-XTR-2465917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerisation of 11c-retinyl to at-retinyl (Xenopus tropicalis)
RHEA:72024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate(in) + urate(out) => nicotinate(out) + urate(in)
RHEA:66435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-galactose(out) <=> H(+)(in) + L-galactose(in)
RHEA:19012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-acylpyruvate + H2O <=> a carboxylate + H(+) + pyruvate
REACT:R-SCE-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Saccharomyces cerevisiae)
RHEA:43687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]
RHEA:72819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)
RHEA:47407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH
GO:0047543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecenal reductase activity
GO:0047543	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexadecanal:NADP+ delta2-oxidoreductase activity
GO:0047543	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexadecanal: NADP+ oxidoreductase activity
REACT:R-HSA-2162002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Homo sapiens)
REACT:R-HSA-9691174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the ER membrane (Homo sapiens)
REACT:R-BTA-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Bos taurus)
RHEA:54718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
RHEA:29010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + Mn(2+)(in) <=> H(+)(out) + Mn(2+)(out)
REACT:R-RNO-174739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant + apoE => chylomicron remnant:apoE complex (Rattus norvegicus)
GO:0018568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenanthrene dioxygenase activity
RHEA:35803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate + H(+)
REACT:R-CFA-417858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y14 receptor can bind to UDP-glucose (Canis familiaris)
REACT:R-BTA-5668545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK autophosphorylates on T559 (Bos taurus)
REACT:R-HSA-427656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-HSA-8938951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PAX5 (BSAP) (Homo sapiens)
RHEA:51083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-166245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Bos taurus)
REACT:R-DDI-193455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Dictyostelium discoideum)
RHEA:51075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenol + an aryl sulfate <=> a phenol + an aryl sulfate
REACT:R-HSA-1500781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgd1 reactivates F420 (Homo sapiens)
RHEA:59002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + propanoate => H2O + O2 + propanal
REACT:R-PFA-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Plasmodium falciparum)
REACT:R-SSC-2730843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LAT by p-SYK (Sus scrofa)
RHEA:27784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-octaprenyl diphosphate
REACT:R-BTA-997309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of STAT1 by SHP2 (Bos taurus)
GO:0004665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
GO:0004665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prephenate dehydrogenase (NADP+) activity
GO:0004665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prephenate:NADP+ oxidoreductase (decarboxylating)
RHEA:30617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-zeta-carotene => 15-cis-phytoene + 2 A
RHEA:49312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans,4-trans-xanthoxin + NAD(+) = 2-trans-(+)-abscisic aldehyde + H(+) + NADH
REACT:R-CEL-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Caenorhabditis elegans)
REACT:R-RNO-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)
RHEA:41585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-tyrosine => 4-O-dimethylallyl-L-tyrosine + diphosphate
REACT:R-PFA-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Plasmodium falciparum)
RHEA:69636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
REACT:R-BTA-202129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)
REACT:R-MMU-9027624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DHA to 7-HDHA (Mus musculus)
REACT:R-RNO-433089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT can transport taurolithocholate-3-sulphate (Rattus norvegicus)
REACT:R-BTA-1234177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)
REACT:R-MMU-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Mus musculus)
REACT:R-DRE-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Danio rerio)
RHEA:61397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]
REACT:R-RNO-914036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)
REACT:R-CFA-197250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)
RHEA:68866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + D-glucose => H2O + isomaltose
RHEA:35540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 => albonoursin + H2O2
REACT:R-MMU-990489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-13 is a dimer (Mus musculus)
REACT:R-MMU-174731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of newly synthesized ApoB-48 (Mus musculus)
RHEA:11601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CMP => ADP + CDP
REACT:R-DDI-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Dictyostelium discoideum)
REACT:R-SSC-8865667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPA hydrolyses sterol esters to sterols and fatty acids (Sus scrofa)
RHEA:18859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0047703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-nitropropanoate:NADP+ oxidoreductase activity
GO:0047703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	b-nitroacrylate reductase activity
GO:0047703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nitroacrylate reductase activity
REACT:R-XTR-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Xenopus tropicalis)
REACT:R-HSA-5244669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Homo sapiens)
REACT:R-MMU-192054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Mus musculus)
REACT:R-SSC-8950522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1:p-STAT4 translocates to the nucleus (Sus scrofa)
RHEA:63098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ilicicolin C => ilicicolin A epoxide
REACT:R-CEL-9641089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin binds Ub:UBE2N:UBE2V1 (Caenorhabditis elegans)
RHEA:54751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + firefly L-luciferin <=> AMP + diphosphate + L-firefly luciferyl-CoA
GO:0033841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6G-FT
GO:0033841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6(G)-fructosyltransferase"
GO:0033841	skos:altLabel	"6(G)-fructotransferase"
GO:0033841	skos:altLabel	"6(G)-FT"
GO:0033841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructan:fructan 6G-fructosyltransferase activity
GO:0033841	skos:prefLabel	"6(G)-fructosyltransferase"
GO:0033841	skos:altLabel	"fructan:fructan 6(G)-fructosyltransferase"
GO:0033841	skos:altLabel	"6(G)-FFT"
GO:0033841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6G-fructosyltransferase activity
GO:0033841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6G-fructotransferase activity
GO:0033841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6G-FFT
GO:0033841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity
REACT:R-CFA-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Canis familiaris)
REACT:R-XTR-5218839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Xenopus tropicalis)
REACT:R-CEL-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophanyl ribonucleic synthetase activity
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan-tRNA ligase activity
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan-tRNATrp ligase (AMP-forming)
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophanyl-transfer ribonucleic synthetase activity
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophanyl-tRNA synthetase activity
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan translase activity
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan:tRNATrp ligase (AMP-forming)
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophanyl-transfer ribonucleate synthetase activity
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophanyl-transfer RNA synthetase activity
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophanyl-tRNA synthase activity
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophanyl-transfer ribonucleic acid synthetase activity
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity
GO:0004830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TrpRS activity
RHEA:17399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxoacyl-[ACP] + H(+) + NADPH => a (3R)-hydroxyacyl-[ACP] + NADP(+)
RHEA:12572	skos:prefLabel	"adenosylcobinamide-phosphate synthase"
RHEA:12572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylcobinamide-phosphate synthase"
RHEA:12572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide + ADP + H(+) + phosphate
RHEA:12572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate
REACT:R-RNO-70859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Rattus norvegicus)
REACT:R-BTA-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Bos taurus)
REACT:R-RNO-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Rattus norvegicus)
RHEA:41995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH
RHEA:62117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + iminosuccinate => NH4(+) + oxaloacetate
RHEA:68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + propanoate => AMP + diphosphate + NADP(+) + propanal
REACT:R-RNO-427337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBD2 binds methylcytosine in chromatin (Rattus norvegicus)
RHEA:37148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA
GO:0034825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetralin ring-hydroxylating dioxygenase activity
GO:0004850	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyrimidine phosphorylase activity
GO:0004850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UPase activity
GO:0004850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine phosphorylase activity
GO:0004850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine:phosphate alpha-D-ribosyltransferase activity
GO:0004850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UPH
GO:0004850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UrdPase activity
REACT:R-CFA-936390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD mediated deubiquitination of DDX58 (RIG-I) (Canis familiaris)
REACT:R-SSC-2294590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds phosphorylated condensin II complex (Sus scrofa)
RHEA:64164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-L-serine = formaldehyde + L-alanine
REACT:R-MMU-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Mus musculus)
REACT:R-BTA-193535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)
REACT:R-HSA-2671876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT5 Dissociates from Leptin Receptor (Homo sapiens)
REACT:R-XTR-8876615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB13 GEFs exchange GTP for GDP on RAB13 (Xenopus tropicalis)
RHEA:69816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cathasterone + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone
REACT:R-BTA-1237045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Bos taurus)
REACT:R-XTR-9012689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Xenopus tropicalis)
RHEA:51668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone
RHEA:56864	skos:prefLabel	"coelimycin P1 polyketide synthase"
RHEA:56864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)
RHEA:56864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coelimycin P1 polyketide synthase"
RHEA:62231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ascladiol + A <=> AH2 + patulin
RHEA:32895	skos:prefLabel	"1,8-cineole 2-exo-monooxygenase"
RHEA:32895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,8-cineole 2-exo-monooxygenase"
RHEA:32895	skos:altLabel	"CYP3A4"
REACT:R-MMU-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Mus musculus)
RHEA:66012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O
REACT:R-DDI-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Dictyostelium discoideum)
REACT:R-BTA-9714477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the mitochondrial outer membrane (Bos taurus)
REACT:R-CFA-2685505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPCN1/2 transport lysosomal Ca2+ to cytosol  (Canis familiaris)
RHEA:41359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacteriochlorophyll a + 3 NADP(+) <=> geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH
RHEA:59972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + L-seryl-[protein] = CoA + O-decanoyl-L-seryl-[protein]
RHEA:17344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) <=> 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH
RHEA:52430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+) => 12-oxo-leukotriene B4 + H(+) + NADH
EC:3.2.1.71	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan endo-1,2-beta-glucosidase"
EC:3.2.1.71	skos:altLabel	"endo-1,2-beta-glucanase"
EC:3.2.1.71	skos:prefLabel	"glucan endo-1,2-beta-glucosidase"
REACT:R-RNO-159790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Rattus norvegicus)
REACT:R-CFA-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Canis familiaris)
REACT:R-HSA-6784402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde (Homo sapiens)
RHEA:44827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine
REACT:R-DME-6797974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRTMs bind NRXNs (Drosophila melanogaster)
RHEA:21557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[calmodulin]-L-lysine + S-adenosyl-L-methionine => [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine
GO:0050165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantetheine kinase (phosphorylating)
GO:0050165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pantetheine kinase activity
GO:0050165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:pantetheine 4'-phosphotransferase activity
REACT:R-HSA-9618394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL4C gene transcription regulated by NR1H2,3 (Homo sapiens)
RHEA:69148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermine = H2O2 + NH4(+) + spermine monoaldehyde
RHEA:39315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA = (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O
RHEA:59309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactono-1,5-lactone + H2O => D-galactonate + H(+)
REACT:R-MMU-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Mus musculus)
RHEA:26454	skos:prefLabel	"acrylyl-CoA reductase (NADPH)"
RHEA:26454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH
RHEA:26454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acrylyl-CoA reductase (NADPH)"
REACT:R-HSA-9008036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds to HIVEP3 and WWP1 (Homo sapiens)
REACT:R-DRE-2160935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 ubiquitinates RHOA (Danio rerio)
REACT:R-SSC-9014295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GAPs stimulate RAC2 GTPase activity (Sus scrofa)
RHEA:19455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + pyruvate => 2-oxoglutarate + L-alanine
REACT:R-DRE-5649800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Danio rerio)
RHEA:26131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate <=> diphosphate + isopimara-7,15-diene
RHEA:41945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP
REACT:R-CFA-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
RHEA:61625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + cadaverine => 5-aminopentanal + L-glutamate
REACT:R-BTA-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Bos taurus)
RHEA:24446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
RHEA:52288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + phosphate => a myo-inositol phosphate + H2O
RHEA:20880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH
RHEA:20880	skos:prefLabel	"omega-hydroxydecanoate dehydrogenase"
RHEA:20880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"omega-hydroxydecanoate dehydrogenase"
RHEA:18756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + NADP(+) <=> [protein]-disulfide + H(+) + NADPH
RHEA:42155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine
REACT:R-CFA-1602374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Canis familiaris)
RHEA:31254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxyisobutanoyl-CoA + H2O <=> (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)
REACT:R-HSA-8856189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF8 binds TNFRSF8 (Homo sapiens)
RHEA:11948	skos:prefLabel	"4-hydroxybenzoyl-CoA thioesterase"
RHEA:11948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoyl-CoA thioesterase"
RHEA:11948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H(+)
REACT:R-SSC-2162225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from small HA fragments (Sus scrofa)
RHEA:59271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6)-methyl-L-lysyl-[protein] <=> AH2 + formaldehyde + L-lysyl-[protein]
RHEA:54345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-SPO-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Schizosaccharomyces pombe)
REACT:R-SSC-8850356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds microbial lipid-based antigen via CD1 (Sus scrofa)
GO:0008066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate receptor activity
REACT:R-RNO-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)
REACT:R-MMU-446694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 phosphorylates IRAK1 (Mus musculus)
RHEA:49211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
GO:0015389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine- and adenine-specific:sodium symporter activity
RHEA:53415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
GO:0047936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose 1-dehydrogenase [NAD(P)] activity
GO:0047936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose dehydrogenase (NAD(P))
GO:0047936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexose phosphate dehydrogenase activity
GO:0047936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-glucose:NAD(P)+ 1-oxidoreductase activity
REACT:R-SSC-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Sus scrofa)
RHEA:42284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
RHEA:34087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol = a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester
RHEA:67673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate
REACT:R-HSA-5660015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RPIA does not isomerize R5P to RU5P (Homo sapiens)
RHEA:57758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH
RHEA:68725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:52323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tryptamine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin
RHEA:53764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholate + lithocholoyl-CoA = allocholoyl-CoA + lithocholate
REACT:R-DME-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Drosophila melanogaster)
REACT:R-HSA-9612593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds DLG4 (Homo sapiens)
REACT:R-GGA-390597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Gallus gallus)
RHEA:44611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
RHEA:12365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) => a quinol + beta-nicotinamide D-riboside
GO:0018472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthaldehyde dehydrogenase activity
RHEA:35512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Mus musculus)
RHEA:19812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + 2 H(+) + H2O <=> CO2 + glyoxylate + 2 NH4(+)
RHEA:12815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate => L-glutamate
REACT:R-CFA-5432825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds TLR4:LY96 (Canis familiaris)
REACT:R-SSC-209821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of N-acetyl-5-HT to form melatonin (Sus scrofa)
REACT:R-SPO-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Schizosaccharomyces pombe)
RHEA:51525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-corytuberine + S-adenosyl-L-methionine => magnoflorine + S-adenosyl-L-homocysteine
REACT:R-MMU-77304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Mus musculus)
REACT:R-HSA-191999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Homo sapiens)
REACT:R-SCE-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Saccharomyces cerevisiae)
RHEA:27796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate + 4 diphosphate => (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate
RHEA:36689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoylsphing-4-enine => hexadecanoyl-CoA + sphing-4-enine
REACT:R-CFA-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Canis familiaris)
REACT:R-HSA-9619034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs translocate from ER lumen to extracellular region (Homo sapiens)
REACT:R-CEL-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Caenorhabditis elegans)
REACT:R-DME-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Drosophila melanogaster)
RHEA:56837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[PQQ precursor protein] + S-adenosyl-L-methionine => 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine
REACT:R-SSC-1299359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TALK (Sus scrofa)
REACT:R-CEL-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Caenorhabditis elegans)
RHEA:69071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline <=> A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide
REACT:R-RNO-2076383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3ST1 sulfates GlcN at C3 in heparan sulfate (Rattus norvegicus)
GO:0061513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Homo sapiens)
GO:0061513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose 6-phosphate:inorganic phosphate antiporter activity
GO:0061513	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glucose 6-phosphate:phosphate antiporter activity
GO:0030159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor signaling complex scaffold protein activity
GO:0030159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor signaling complex scaffold activity
GO:0030159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor signaling complex adaptor activity
GO:0030159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling receptor complex adaptor activity
GO:0030159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor signalling complex scaffold activity
GO:0030159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor signalling complex adaptor activity
REACT:R-RNO-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Rattus norvegicus)
REACT:R-XTR-202214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Lck-pY505 by CD45 (Xenopus tropicalis)
REACT:R-BTA-6804379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds TTC5 (Bos taurus)
RHEA:61618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + N-methyl-L-proline + NAD(+) => H(+) + L-proline betaine + NADH + O2
RHEA:71972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyglutarate(out) + 3 Na(+)(out) => 3-hydroxyglutarate(in) + 3 Na(+)(in)
REACT:R-CFA-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Canis familiaris)
REACT:R-DRE-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Danio rerio)
REACT:R-XTR-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Xenopus tropicalis)
RHEA:36209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA
REACT:R-GGA-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Gallus gallus)
REACT:R-GGA-5675373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)
RHEA:41676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-HSA-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Homo sapiens)
RHEA:23148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"propionate kinase"
RHEA:23148	skos:prefLabel	"propionate kinase"
RHEA:23148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + propanoate = ADP + propanoyl phosphate
RHEA:23148	skos:altLabel	"propionate/acetate kinase"
RHEA:52056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + hexadecanoate
REACT:R-MMU-198599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MDM2 (Mus musculus)
RHEA:54410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
RHEA:34722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine 1-phosphate <=> (2E)-13-methyltetradecenal + phosphoethanolamine
REACT:R-XTR-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Xenopus tropicalis)
REACT:R-SSC-9026777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Sus scrofa)
RHEA:55338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine
RHEA:32602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> 3-isopropenyl-6-oxoheptanoate + H(+)
RHEA:22870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + H(+) + S-carboxymethyl-L-cysteine => 3-chloro-L-alanine + thioglycolate
RHEA:57125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate => 2-hydroxy-5-oxoproline
GO:0050659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity
GO:0050659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
GO:0050659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity
GO:0050659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GalNAc4S-6ST
RHEA:43737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-RNO-5362525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1,C1 4-hydroxylate atRA (Rattus norvegicus)
RHEA:15890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamine => L-glutamate + NH4(+)
RHEA:60307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-DME-432521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear TIM is degraded by the 26S proteasome (Drosophila melanogaster)
RHEA:67175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] <=> formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite
RHEA:58164	skos:prefLabel	"eudesmane-5,11-diol synthase"
RHEA:58164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"eudesmane-5,11-diol synthase"
RHEA:58164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 2 H2O = 7-epi-ent-eudesmane-5,11-diol + diphosphate
REACT:R-BTA-5638332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Bos taurus)
RHEA:63316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = 9-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-RNO-5683930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WICH phosphorylates H2AFX on Y142 (Rattus norvegicus)
REACT:R-CFA-6786166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translesion synthesis across unhooked ICL by POLN (Canis familiaris)
REACT:R-HSA-8944266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XI (Homo sapiens)
REACT:R-BTA-2730858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of BTK/ITK (Bos taurus)
REACT:R-DME-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Drosophila melanogaster)
REACT:R-HSA-375155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with agrin (Homo sapiens)
REACT:R-CFA-1655851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2P hydrolyzes SREBP1A,1C,2 (Canis familiaris)
RHEA:50099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-936986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains (Canis familiaris)
REACT:R-RNO-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Rattus norvegicus)
REACT:R-XTR-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)
REACT:R-CEL-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Caenorhabditis elegans)
RHEA:36061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + urocanate => A + dihydrourocanate
EC:1.1.1.339	skos:prefLabel	"dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(+))"
EC:1.1.1.339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(+))"
GO:0097718	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	disordered protein domain specific binding
GO:0097718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	disordered domain specific binding
REACT:R-CEL-416546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Caenorhabditis elegans)
RHEA:68318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,4,5-triphosphate + phosphate => 1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O
REACT:R-DDI-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Dictyostelium discoideum)
REACT:R-GGA-2993763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Gallus gallus)
RHEA:31843	skos:prefLabel	"2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase"
RHEA:31843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase"
RHEA:31843	skos:altLabel	"1,2-epoxyphenylacetyl-CoA isomerase"
RHEA:31843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA
RHEA:40059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H2O = CoA + decanoate + H(+)
RHEA:54457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
REACT:R-HSA-2031355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
REACT:R-MMU-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Mus musculus)
RHEA:72450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate(in) + estrone 3-sulfate(out) <=> a dicarboxylate(out) + estrone 3-sulfate(in)
RHEA:16059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:23169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coformycin + NADP(+) => 8-oxocoformycin + H(+) + NADPH
REACT:R-HSA-8847635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic (Homo sapiens)
REACT:R-XTR-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Xenopus tropicalis)
GO:0004344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soluble glucose dehydrogenase
GO:0004344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose dehydrogenase activity
GO:0004344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose dehydrogenase (acceptor) activity
RHEA:24897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyxanthotoxin + S-adenosyl-L-methionine <=> isopimpinellin + S-adenosyl-L-homocysteine
REACT:R-DRE-983424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of COPII coated vesicle (Danio rerio)
RHEA:68923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + pentanoate <=> AMP + diphosphate + NADP(+) + pentanal
RHEA:63133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin => cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione
REACT:R-DRE-4551727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Danio rerio)
RHEA:12895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E2 => prostaglandin H2
RHEA:18813	skos:prefLabel	"5-carboxymethyl-2-hydroxymuconate Delta-isomerase"
RHEA:18813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-carboxymethyl-2-hydroxymuconate Delta-isomerase"
RHEA:18813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate
RHEA:18813	skos:altLabel	"CHM isomerase"
RHEA:18813	skos:altLabel	"5-carboxymethyl-2-hydroxymuconic acid isomerase"
RHEA:47175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADH
REACT:R-CFA-8982637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins binds G alpha-t (Canis familiaris)
REACT:R-MMU-8851929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Mus musculus)
REACT:R-MMU-165758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and inactivation of eEF2K by activated S6K1 (Mus musculus)
GO:0005053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisome targeting signal-2 binding
GO:0005053	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peroxisome targeting signal-2 receptor
GO:0005053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisomal targeting signal 2 (PTS2) binding
GO:0005053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisome matrix targeting signal-2 binding
GO:0005053	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PEX7
GO:0005053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTS2 binding
GO:0005053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTS2 receptor
REACT:R-DRE-167427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid dissociates from MOR (Danio rerio)
REACT:R-DME-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)
REACT:R-MMU-2424477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS mediated nucleotide exchange of RAS (SHC) (Mus musculus)
REACT:R-XTR-8863804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Xenopus tropicalis)
RHEA:39083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanedioyl-CoA + CoA = acetyl-CoA + decanedioyl-CoA
REACT:R-GGA-164620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Gallus gallus)
REACT:R-RNO-2213200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of endostatin-like peptides (Rattus norvegicus)
REACT:R-XTR-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Xenopus tropicalis)
RHEA:59136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + D-ornithine = AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine
RHEA:59136	skos:prefLabel	"D-ornithine--citrate ligase"
RHEA:59136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-ornithine--citrate ligase"
REACT:R-BTA-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Bos taurus)
REACT:R-SPO-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Schizosaccharomyces pombe)
REACT:R-HSA-8952232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL2L11 (BIM) gene transcription is stimulated by RUNX3 (Homo sapiens)
REACT:R-DME-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Drosophila melanogaster)
REACT:R-GGA-140783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Gallus gallus)
REACT:R-BTA-6807055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR7 reduces 7-dehydroCHOL to CHOL (Bos taurus)
RHEA:44819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-12 + CO2 + diphosphate
REACT:R-XTR-202710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MERTK receptor binds ligands (Gas6 or Protein S) (Xenopus tropicalis)
EC:1.14.18.6	skos:prefLabel	"4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase"
EC:1.14.18.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase"
GO:0044020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine N-methyltransferase activity (H4-R3 specific)
GO:0044020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4R3 arginine methylase activity
GO:0044020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H4-R3 specific)
GO:0044020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H4-R3 specific)
GO:0044020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4R3 methyltransferase activity
RHEA:32479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH
RHEA:32479	skos:prefLabel	"iodotyrosine deiodinase"
RHEA:32479	skos:altLabel	"iodotyrosine dehalogenase 1"
RHEA:32479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"iodotyrosine deiodinase"
REACT:R-RNO-6804253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates JMY (Rattus norvegicus)
RHEA:53832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate
RHEA:54207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-2197646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1 (SR-BI, CLA-1) binds ligands (Homo sapiens)
RHEA:20829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2
RHEA:63730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	candesartan-2-N-beta-D-glucuronide + UDP => candesartan + UDP-alpha-D-glucuronate
REACT:R-BTA-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)
REACT:R-CFA-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Canis familiaris)
RHEA:32110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine <=> H(+) + pterostilbene + S-adenosyl-L-homocysteine
RHEA:71731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + tartrate(in) = citrate(in) + tartrate(out)
GO:0102404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity
REACT:R-DRE-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Danio rerio)
RHEA:35160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol
REACT:R-MMU-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Mus musculus)
RHEA:30101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+)
RHEA:41019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA
RHEA:40756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate
REACT:R-MMU-5696358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREM,CD300 binds lipids (Mus musculus)
RHEA:18696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + penicillin <=> 6-aminopenicillanate + a carboxylate
REACT:R-HSA-6786114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL13:IL13RA:TYK2 binds IL4R:JAK2 (Homo sapiens)
RHEA:69527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + O2 <=> D-glucose + H2O2
REACT:R-MMU-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Mus musculus)
REACT:R-DME-2025723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the N-glycan precursor (Drosophila melanogaster)
REACT:R-HSA-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Homo sapiens)
REACT:R-MMU-376369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp2 associated secretory vesicle to plasma membrane transport (Mus musculus)
RHEA:37276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-glutamine => L-alanine + L-glutamine
REACT:R-SSC-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Sus scrofa)
REACT:R-MMU-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Mus musculus)
RHEA:10313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + terephthalate => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)
REACT:R-DRE-429415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to integrin alphaIIb beta3 (Danio rerio)
REACT:R-CEL-176474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Caenorhabditis elegans)
REACT:R-DRE-2464809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates the transport of atROL from ROS to RPE (Danio rerio)
REACT:R-MMU-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Mus musculus)
REACT:R-HSA-1307803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM22 inserts proteins into inner membrane (Homo sapiens)
RHEA:62290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate
REACT:R-DME-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Drosophila melanogaster)
REACT:R-HSA-5654714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
EC:1.3.1.114	skos:prefLabel	"3-dehydro-bile acid Delta(4,6)-reductase"
EC:1.3.1.114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydro-bile acid Delta(4,6)-reductase"
REACT:R-HSA-9705961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp15 cleaves viral poly(U)-RNA (Homo sapiens)
RHEA:37600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O
RHEA:29246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinone-8 + NADH <=> menaquinol-8 + NAD(+)
GO:0004679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP-activated protein kinase activity
GO:0004679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-AMP-activated protein kinase activity
GO:0004679	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMPK activity
GO:0004679	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SNF1A/AMP-activated protein kinase activity
REACT:R-HSA-706479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated (Homo sapiens)
REACT:R-HSA-450499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B (AKT) phosphorylates KSRP (Homo sapiens)
REACT:R-DRE-9032798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK3 activates RAC1 (Danio rerio)
REACT:R-XTR-193460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Xenopus tropicalis)
REACT:R-CEL-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Caenorhabditis elegans)
REACT:R-CFA-5661122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2R3-histone H3 (Canis familiaris)
REACT:R-DME-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Drosophila melanogaster)
RHEA:50808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin J2 = prostaglandin J2-S-(S)-glutathione
GO:1901149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylic acid binding
GO:1901149	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	salicylic acid receptor
REACT:R-XTR-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Xenopus tropicalis)
RHEA:30111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-enterobactin + H(+) + 3 H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine
RHEA:30111	skos:prefLabel	"iron(III) enterobactin esterase"
RHEA:30111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"iron(III) enterobactin esterase"
REACT:R-HSA-174425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)
GO:0140680	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H3K36me demethylase activity
GO:0140680	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K36me2 demethylase activity
GO:0140680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-di/monomethyl-lysine-36 demethylase activity
GO:0140680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36me/H3K36me2 demethylase activity
REACT:R-DME-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Drosophila melanogaster)
REACT:R-CFA-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Canis familiaris)
REACT:R-BTA-9668831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CST complex formation (Bos taurus)
REACT:R-XTR-2032770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1 to the nucleus (Xenopus tropicalis)
RHEA:21135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + xanthine <=> H2O2 + urate
REACT:R-SPO-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Schizosaccharomyces pombe)
REACT:R-MMU-5671702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP1G2 binds HGS and CHMP2A (Mus musculus)
REACT:R-SSC-195418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-2 associates with VEGFR1 forming complexes on  cell surface (Sus scrofa)
RHEA:38059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-SSC-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Sus scrofa)
REACT:R-BTA-5362441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Bos taurus)
RHEA:69264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkanimidothioate = an isothiocyanate + sulfate
RHEA:39113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+)
RHEA:43772	skos:altLabel	"23S rRNA m(7)G(2069) methyltransferase"
RHEA:43772	skos:prefLabel	"23S rRNA (guanine(2069)-N(7))-methyltransferase"
RHEA:43772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (guanine(2069)-N(7))-methyltransferase"
RHEA:43772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-RNO-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Rattus norvegicus)
GO:0000048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyltransferase activity
GO:0000048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity
REACT:R-XTR-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Xenopus tropicalis)
REACT:R-SSC-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Sus scrofa)
RHEA:17439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-2,4-dichloromuconate + H(+) => 2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate
RHEA:14894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ornithine => (2R,4S)-2,4-diaminopentanoate
RHEA:15854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) => 17alpha-hydroxyprogesterone + H(+) + NADH
REACT:R-CFA-5607736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 oligomerizes (Canis familiaris)
REACT:R-BTA-5362448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh C-terminal fragments are degraded by the proteasome (Bos taurus)
GO:0042008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-18R
GO:0042008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-18 receptor activity
GO:0042008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-18 receptor activity
REACT:R-RNO-9661432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds ALB (Rattus norvegicus)
EC:1.14.99.34	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monoprenyl isoflavone epoxidase"
EC:1.14.99.34	skos:altLabel	"monoprenyl isoflavone monooxygenase"
EC:1.14.99.34	skos:prefLabel	"monoprenyl isoflavone epoxidase"
REACT:R-XTR-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Xenopus tropicalis)
REACT:R-BTA-8866304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL binds lipids to form VLDL (Bos taurus)
RHEA:68970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + phenylglyoxylate => mandelate + O2
REACT:R-DRE-5654592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)
REACT:R-RNO-178208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF2 (Rattus norvegicus)
RHEA:65286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+) => 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate
REACT:R-SSC-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Sus scrofa)
REACT:R-HSA-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Homo sapiens)
REACT:R-HSA-5617877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA4 gene is transcribed (Homo sapiens)
REACT:R-GGA-2395328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP1, LTBP3 bind TGF-Beta (Gallus gallus)
REACT:R-GGA-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Gallus gallus)
REACT:R-MMU-8938867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND3,(CCND1,CCND2) binds RUNX1 (Mus musculus)
REACT:R-BTA-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Bos taurus)
RHEA:65479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + butanoyl-CoA <=> CoA + propyl butanoate
RHEA:12020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)
REACT:R-RNO-5686440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81:EME1,EME2 cleaves D-loop (Rattus norvegicus)
RHEA:54799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) <=> an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH
RHEA:63870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,9Z)-2-hydroperoxyoctadecenoate => (9Z)-octadecenoate + O2
REACT:R-SSC-8952382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 polyubiquitinates RUNX3 (Sus scrofa)
REACT:R-MMU-109863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK3:MAP2K1 (Mus musculus)
REACT:R-DME-4641350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TOP2A with SUMO2,3 (Drosophila melanogaster)
REACT:R-SSC-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Sus scrofa)
RHEA:48813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
RHEA:40284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + hexadecanedioyl-CoA => CoA + O-hexadecanedioyl-L-carnitine
REACT:R-BTA-8877620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE2 cleaves EDN1(53-90) (Bos taurus)
REACT:R-CFA-6809264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)
RHEA:30950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-gamma-eudesmol + diphosphate
RHEA:55012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 = (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)
RHEA:29146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + 2 H(+)(in) + nitrate <=> a ubiquinone + 2 H(+)(out) + H2O + nitrite
REACT:R-BTA-3095889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC dealkylates RCbl (Bos taurus)
REACT:R-SCE-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Saccharomyces cerevisiae)
REACT:R-MMU-8944214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type I (Mus musculus)
REACT:R-BTA-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Bos taurus)
RHEA:51867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + esculetin <=> 8-geranylesculetin + diphosphate
RHEA:21813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-8948231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)
RHEA:33184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) => citrate(out)
RHEA:18521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	licodione + S-adenosyl-L-methionine = 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine
RHEA:18521	skos:prefLabel	"licodione 2'-O-methyltransferase"
RHEA:18521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"licodione 2'-O-methyltransferase"
REACT:R-BTA-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Bos taurus)
RHEA:70227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA = (E)-2-benzylidenesuccinyl-CoA + H2O
REACT:R-MMU-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Mus musculus)
RHEA:42035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate
RHEA:23474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose => 2 alpha,alpha'-trehalose 6-mycolate
RHEA:70272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
REACT:R-RNO-5669013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA-3 binds EDA2R (Rattus norvegicus)
GO:0018596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMSD hydroxylase activity
GO:0018596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylsilanediol hydroxylase activity
RHEA:35878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:31534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginine + O2 <=> CO2 + N(omega)-hydroxy-L-arginine + succinate
REACT:R-SSC-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Sus scrofa)
RHEA:69336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-alk-1-en-1-SO-peroxol = (Z)-alkanethial oxide
REACT:R-CFA-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Canis familiaris)
RHEA:19584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-dimethylallyladenine + S-adenosyl-L-methionine <=> discadenine + H(+) + S-methyl-5'-thioadenosine
GO:0070855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin VI head/neck binding
REACT:R-HSA-1989768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TIAM2 (Homo sapiens)
RHEA:38204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CFA-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Canis familiaris)
REACT:R-GGA-9750946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2,6 ubiquitinates NLRC5 (Gallus gallus)
REACT:R-CFA-2395324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyrrole cross-links (Canis familiaris)
RHEA:34464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycopalyl diphosphate => cis-abienol + diphosphate
RHEA:69921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine(in) + 2 Na(+)(in) => inosine(out) + 2 Na(+)(out)
RHEA:51357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-glutamine => (9Z)-octadecenoate + L-glutamine
REACT:R-DME-373705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of DCC (Drosophila melanogaster)
RHEA:12279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-DRE-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Danio rerio)
REACT:R-MMU-351876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of occludin (Mus musculus)
REACT:R-GGA-5654423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Gallus gallus)
REACT:R-CEL-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Caenorhabditis elegans)
REACT:R-SSC-6786110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL13-bound IL13R type II (Sus scrofa)
REACT:R-HSA-113643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Replication initiation regulation by Rb1/E2F1 (Homo sapiens)
REACT:R-CFA-6786720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DECR2 reduces LCtE-CoA to t3enoyl-CoA (Canis familiaris)
REACT:R-DRE-444731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Danio rerio)
RHEA:21742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate => 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol
REACT:R-CFA-180073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Canis familiaris)
REACT:R-XTR-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Xenopus tropicalis)
REACT:R-HSA-749452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
REACT:R-DME-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)
REACT:R-CEL-70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer oxidises LACT to PYR (Caenorhabditis elegans)
RHEA:32899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-cineole + O2 + reduced [flavodoxin] = 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]
RHEA:32899	skos:prefLabel	"1,8-cineole 2-endo-monooxygenase"
RHEA:32899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,8-cineole 2-endo-monooxygenase"
RHEA:32899	skos:altLabel	"P450cin"
RHEA:32899	skos:altLabel	"CYP176A"
RHEA:32899	skos:altLabel	"CYP176A1"
GO:0010461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	light-activated ion channel activity
RHEA:17480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6B + 2 S-adenosyl-L-methionine <=> CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine
REACT:R-RNO-168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
REACT:R-BTA-8964619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds ARHGEF6 (Bos taurus)
RHEA:72019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + O2 + trihazone A = 2 CO2 + H2O + succinate + trihazone D
RHEA:20595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + D-glucosamine => H2O + N-acetyl-D-glucosamine
GO:0102653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity
REACT:R-SSC-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Sus scrofa)
RHEA:69848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in RNA + NADP(+) => a uridine in RNA + H(+) + NADPH
REACT:R-SSC-3788725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C complex binds EHMT1:EHMT2 (Sus scrofa)
REACT:R-HSA-9603407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds PI3K (Homo sapiens)
REACT:R-RNO-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Rattus norvegicus)
REACT:R-CFA-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Canis familiaris)
REACT:R-SSC-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Sus scrofa)
REACT:R-RNO-196126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from cytosol to mitochondrial intermembrane space (Rattus norvegicus)
REACT:R-GGA-2022411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)
REACT:R-SSC-3640872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP34 deubiquitinates AXIN1,AXIN2 (Sus scrofa)
RHEA:50393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline => 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-CFA-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Canis familiaris)
REACT:R-GGA-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Gallus gallus)
RHEA:40907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-BTA-9634861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT2 (Bos taurus)
REACT:R-HSA-9645524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose binds TIFA (Homo sapiens)
REACT:R-RNO-8848339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA5 hydrolyzes TAG (Rattus norvegicus)
REACT:R-SSC-1296035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Sus scrofa)
REACT:R-DME-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Drosophila melanogaster)
REACT:R-SCE-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Saccharomyces cerevisiae)
REACT:R-BTA-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Bos taurus)
REACT:R-DRE-170076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Danio rerio)
REACT:R-SSC-379395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates 3MT to HVA (Sus scrofa)
REACT:R-SSC-69600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic degradation of ubiquitinated-Cdc25A (Sus scrofa)
RHEA:17620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene C4 <=> glutathione + leukotriene A4
RHEA:12207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-8848774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds DOK1 (Bos taurus)
RHEA:59765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-CEL-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)
REACT:R-CFA-265425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with von Willbrand Factor (Canis familiaris)
REACT:R-CFA-159819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Canis familiaris)
REACT:R-SSC-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Sus scrofa)
REACT:R-SSC-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Sus scrofa)
REACT:R-DRE-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
REACT:R-SCE-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Saccharomyces cerevisiae)
RHEA:50329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) => 2-all-trans-heptaprenylphenol + CO2
RHEA:48513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphinate(out) => ADP + H(+) + phosphate + phosphinate(in)
REACT:R-DRE-158609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers CH3 from AdoMet to 6MP (Danio rerio)
REACT:R-CEL-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Caenorhabditis elegans)
REACT:R-MMU-727819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 phosphorylates MKK6 (Mus musculus)
RHEA:23867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol 2-phosphate <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP
REACT:R-BTA-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Bos taurus)
RHEA:31678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + raucaffrinoline <=> H(+) + NADPH + perakine
REACT:R-XTR-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Xenopus tropicalis)
RHEA:49008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADPH + O2 = aurachin C epoxide + H2O + NADP(+)
RHEA:30993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:32930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate
REACT:R-HSA-1592314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)
REACT:R-DRE-203774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Csk with PAG (Danio rerio)
RHEA:36657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine => desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine
GO:0003952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD synthase (glutamine-hydrolyzing) activity
GO:0003952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+ synthetase (glutamine-hydrolyzing)
GO:0003952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ synthase (glutamine-hydrolyzing) activity
GO:0003952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide synthetase (glutamine) activity
GO:0003952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD synthetase (glutamine-hydrolysing)
GO:0003952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPN synthetase activity
GO:0003952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deamido-NAD+:L-glutamine amido-ligase (AMP-forming)
GO:0003952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(+) synthetase (glutamine-hydrolyzing) activity
GO:0003952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desamidonicotinamide adenine dinucleotide amidotransferase activity
GO:0003952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+ synthase (glutamine-hydrolysing)
REACT:R-RNO-350604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Agmatine + H2O <=> putrescine + urea (Rattus norvegicus)
RHEA:60685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) => (11R)-dihydroartemisinate + 2 H(+) + NADPH
REACT:R-RNO-2022383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)
GO:0102751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity
RHEA:20783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GMP <=> ADP + GDP
REACT:R-DRE-4755479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKB2 with SUMO1 (Danio rerio)
GO:0046406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity
GO:0046406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity
GO:0046406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	magnesium-protoporphyrin O-methyltransferase activity
GO:0046406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity
GO:0046406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity
GO:0046406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity
GO:0046406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity
GO:0046406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mg-protoporphyrin IX methyltransferase activity
GO:0046406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	magnesium protoporphyrin IX methyltransferase activity
REACT:R-MMU-187035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-beta-NGF and mature beta-NGF are secreted (Mus musculus)
REACT:R-HSA-158218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Homo sapiens)
RHEA:17645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] = N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate
REACT:R-HSA-9761825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds the ME1 gene (Homo sapiens)
REACT:R-HSA-177694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 (Homo sapiens)
REACT:R-CEL-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Caenorhabditis elegans)
REACT:R-CFA-6785986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases unhook the interstrand crosslink (ICL) (Canis familiaris)
RHEA:72852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + AMP(in) => ADP(in) + AMP(out)
REACT:R-MMU-2404134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4:atROL binds TTR (Mus musculus)
RHEA:24728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indolmycin + S-adenosyl-L-homocysteine => N-demethylindolmycin + S-adenosyl-L-methionine
REACT:R-CEL-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Caenorhabditis elegans)
REACT:R-DME-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Drosophila melanogaster)
RHEA:35406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) <=> (3R)-vestitone + H(+) + NADPH
REACT:R-DRE-1364044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR:JAK2 dimerizes (Danio rerio)
RHEA:32500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,5R)-sabinene + H(+) + NADPH + O2 => (1S,3R,5S)-sabinol + H2O + NADP(+)
REACT:R-MMU-416690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4A binds to PLXND1 (Mus musculus)
RHEA:58491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate + H(+) + NADH + O2 <=> H2O + NAD(+) + succinate semialdehyde + trimethylamine
REACT:R-DRE-549322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations out of hepatic cells (Danio rerio)
REACT:R-MMU-5672972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
RHEA:35663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
RHEA:54899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,15Z)-12-oxophytodienoate + ATP + CoA <=> (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate
REACT:R-SPO-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Schizosaccharomyces pombe)
RHEA:21615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + H2O
REACT:R-CFA-2046092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Canis familiaris)
REACT:R-DRE-417927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y2 receptor binds ATP and UTP (Danio rerio)
RHEA:71209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide(in) + 2 Na(+)(in) => iodide(out) + 2 Na(+)(out)
REACT:R-DRE-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Danio rerio)
REACT:R-BTA-373724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds NCK (Bos taurus)
REACT:R-RNO-844447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 senses MDP (Rattus norvegicus)
REACT:R-RNO-9700662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)
REACT:R-HSA-9731047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 6 binds to NMI (Homo sapiens)
RHEA:51379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-dopamine
RHEA:38382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-SCE-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Saccharomyces cerevisiae)
RHEA:59724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaono-1,5-lactone + H2O = D-maltoheptaonate + H(+)
GO:0050007	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nocardicin aminocarboxypropyltransferase activity
GO:0050007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isonocardicin synthase activity
GO:0050007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isonocardicin synthase"
GO:0050007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocardicin G + S-adenosyl-L-methionine = H(+) + isonocardicin C + S-methyl-5'-thioadenosine
GO:0050007	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity
GO:0050007	skos:prefLabel	"isonocardicin synthase"
GO:0050007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocardicin E + S-adenosyl-L-methionine = H(+) + isonocardicin A + S-methyl-5'-thioadenosine
RHEA:29700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide(in) => dimethyl sulfoxide(out)
RHEA:18414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:50574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein]
RHEA:66149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + acetyl-CoA => CoA + H(+) + N-(2-phenylethyl)acetamide
RHEA:42124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol + NAD(+) = androsterone + H(+) + NADH
RHEA:53762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholoyl-CoA + deoxycholate => allocholate + deoxycholoyl-CoA
RHEA:22885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + glycine
RHEA:34361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + a carboxylate + H(+) => a 1,2-diacylglycerol + H2O
REACT:R-CFA-5669023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TWEAK binds FN14 (Canis familiaris)
REACT:R-SSC-3159259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAA:MUT binds AdoCbl (Sus scrofa)
GO:0047117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl-acyl-carrier-protein reductase (NADPH, A-specific)
GO:0047117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)
GO:0047117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl-ACp reductase activity
GO:0047117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity
GO:0047117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
GO:0047117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
GO:0047117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-ACP reductase (NADPH, A-specific) activity
GO:0047436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMDASE
GO:0047436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aryl-2-methylmalonate carboxy-lyase activity
GO:0047436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)
GO:0047436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMDase activity
GO:0047436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylmalonate decarboxylase activity
REACT:R-HSA-9706315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SH2B3 (Homo sapiens)
REACT:R-HSA-8984014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Homo sapiens)
REACT:R-MMU-1912379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of fringe-modified NOTCH to plasma membrane (Mus musculus)
RHEA:44841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + octadecanoyl-CoA => CoA + O-octadecanoyl-(R)-carnitine
RHEA:49773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoylglycine
RHEA:65009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + decanoate + H(+) => decanoyl-AMP + diphosphate
RHEA:64490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA => acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA
REACT:R-BTA-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)
REACT:R-RNO-159566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Rattus norvegicus)
REACT:R-MMU-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Mus musculus)
RHEA:21304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0043530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5' monophosphoramidase activity
GO:0043530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-monophosphoramidate hydrolase activity
GO:0043530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphoramidate + H2O = AMP + NH4(+)
GO:0043530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-monophosphoramidase activity
GO:0050054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lignostilbene alpha beta-dioxygenase activity
GO:0050054	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lignostilbene alphabeta-dioxygenase activity
GO:0050054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lignostilbene ab-dioxygenase activity
GO:0050054	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)
RHEA:38244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + eicosan-1-ol => 1-O-eicosanyl (9Z)-octadecenoate + CoA
RHEA:68742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol + NADP(+) => 7-oxocholesterol + H(+) + NADPH
GO:0052610	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-ring carotenoid 3-hydroxylase activity
GO:0052610	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carotene beta-ring hydroxylase activity
GO:0052610	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-carotene hydroxylase activity
GO:0052610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin hydroxylase activity
REACT:R-XTR-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Xenopus tropicalis)
REACT:R-CFA-75090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR1 homodimer to dsRNA duplex (Canis familiaris)
REACT:R-MMU-109480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Mus musculus)
REACT:R-GGA-983425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Gallus gallus)
REACT:R-SSC-378952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin is a heterodimer (Sus scrofa)
RHEA:14074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-glutamate + H(+) => 4-amino-3-hydroxybutanoate + CO2
RHEA:22934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose
REACT:R-CFA-2395328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP1, LTBP3 bind TGF-Beta (Canis familiaris)
RHEA:49816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Fe(III)-[cytochrome c] + H2O + hydrazine = 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide
RHEA:49816	skos:prefLabel	"hydrazine synthase"
RHEA:49816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrazine synthase"
REACT:R-RNO-202216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 (Rattus norvegicus)
REACT:R-MMU-9706328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS2 (Mus musculus)
REACT:R-CFA-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Canis familiaris)
REACT:R-HSA-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Homo sapiens)
REACT:R-HSA-9670426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants (Homo sapiens)
REACT:R-XTR-5654397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS2 (Xenopus tropicalis)
GO:0102400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity
RHEA:11077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 3 H(+) + NADH + O2 => catechol + CO2 + NAD(+) + NH4(+)
REACT:R-HSA-9680836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NS5B binds ribavirin (Homo sapiens)
RHEA:70301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxo-L-gulonate => H2O + L-dehydroascorbate
REACT:R-HSA-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Homo sapiens)
REACT:R-SSC-8943003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH polyubiquitinates monoubiquitinated PCNA (Sus scrofa)
RHEA:57727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 Na(+)(in) + oxaloacetate <=> CO2 + 2 Na(+)(out) + pyruvate
REACT:R-BTA-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Bos taurus)
RHEA:42131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine
GO:0008924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate:(quinone) oxidoreductase activity
GO:0008924	skos:altLabel	"malate dehydrogenase (acceptor)"
GO:0008924	skos:altLabel	"malate quinone oxidoreductase"
GO:0008924	skos:altLabel	"FAD-dependent malate dehydrogenase"
GO:0008924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD-dependent malate dehydrogenase activity
GO:0008924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate:quinone oxidoreductase activity
GO:0008924	skos:altLabel	"MQO"
GO:0008924	skos:prefLabel	"malate dehydrogenase (quinone)"
GO:0008924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malate dehydrogenase (quinone)"
GO:0008924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate dehydrogenase (quinone) activity
GO:0008924	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	MQO activity
GO:0044669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:galactoside symporter activity
REACT:R-DDI-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Dictyostelium discoideum)
REACT:R-HSA-5655266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)
REACT:R-DRE-5689317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the pre-incision complex in GG-NER (Danio rerio)
REACT:R-XTR-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Xenopus tropicalis)
REACT:R-RNO-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
REACT:R-DME-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Drosophila melanogaster)
REACT:R-BTA-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Bos taurus)
REACT:R-HSA-5690886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)
REACT:R-DRE-417820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 receptor can bind to LPA (Danio rerio)
REACT:R-DRE-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Danio rerio)
REACT:R-SSC-5693620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop formation mediated by PALB2, BRCA2 and RAD51 (Sus scrofa)
REACT:R-MMU-8949668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YME1L1 proteolyzes unassembled proSMDT1 (Mus musculus)
RHEA:56227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP
REACT:R-GGA-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Gallus gallus)
REACT:R-CFA-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Canis familiaris)
REACT:R-RNO-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Rattus norvegicus)
RHEA:63082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + AMP + diphosphate + ilicicolin B => AH2 + ATP + ilicicolinate B
REACT:R-BTA-8849463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates SFPQ (Bos taurus)
REACT:R-HSA-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Homo sapiens)
REACT:R-GGA-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Gallus gallus)
REACT:R-XTR-9611851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 bind ADR,NAd (Xenopus tropicalis)
REACT:R-BTA-8952625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Bos taurus)
RHEA:28143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + streptothricin D => streptothricin D acid
GO:0008466	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	priming glucosyltransferase activity
GO:0008466	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity
GO:0008466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4alpha-glucan-protein synthase (UDP-forming) activity
GO:0008466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,4-glucan-protein synthase (UDP-forming) activity
GO:0008466	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogenin activity
GO:0008466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogenin glucosyltransferase activity
GO:0008466	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:glycogenin glucosyltransferase activity
REACT:R-SCE-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Saccharomyces cerevisiae)
RHEA:12461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate => fumarate + H2O
REACT:R-RNO-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Rattus norvegicus)
RHEA:16601	skos:prefLabel	"aspartate ammonia-lyase"
RHEA:16601	skos:altLabel	"aspartase"
RHEA:16601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate = fumarate + NH4(+)
RHEA:16601	skos:altLabel	"fumaric aminase"
RHEA:16601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate ammonia-lyase"
RHEA:56993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => (+)-costunolide + H2O
REACT:R-GGA-9749583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Gallus gallus)
REACT:R-CFA-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Canis familiaris)
RHEA:44271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-CEL-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Caenorhabditis elegans)
RHEA:31707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al
REACT:R-HSA-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Homo sapiens)
RHEA:13789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)
RHEA:37075	skos:prefLabel	"tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"
RHEA:37075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"
RHEA:37075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
RHEA:37075	skos:altLabel	"methylthio-threonylcarbamoyl-adenosine transferase B"
GO:0097599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylanase activity
GO:0097599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylosidase activity
RHEA:45619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine
REACT:R-HSA-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Homo sapiens)
RHEA:70743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Bos taurus)
REACT:R-CFA-5205799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Canis familiaris)
REACT:R-HSA-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Homo sapiens)
REACT:R-MMU-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Mus musculus)
RHEA:67359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA <=> (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA
GO:0102053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-jasmonoyl-isoleucine synthetase activity
REACT:R-HSA-9694793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike protein gets N-glycosylated (Homo sapiens)
REACT:R-RNO-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Rattus norvegicus)
REACT:R-HSA-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Homo sapiens)
GO:0050448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	b-cyclopiazonate dehydrogenase activity
GO:0050448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cyclopiazonate dehydrogenase activity
GO:0050448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)
GO:0050448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyclopiazonic oxidocyclase activity
GO:0050448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyclopiazonate oxidocyclase activity
GO:0050448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)
EC:3.1.1.94	skos:prefLabel	"versiconal hemiacetal acetate esterase"
EC:3.1.1.94	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"versiconal hemiacetal acetate esterase"
EC:3.1.1.94	skos:altLabel	"VHA esterase"
REACT:R-RNO-9035227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN2 binds CysS248-MPST (Rattus norvegicus)
RHEA:24161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + O2 => D-galacto-hexodialdose + H2O2
GO:0062069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GARP complex binding
RHEA:50681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-terminal L-glutaminyl-[protein] => N-terminal L-glutamyl-[protein] + NH4(+)
REACT:R-SSC-437139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT6 transports zinc into the golgi apparatus (Sus scrofa)
RHEA:48327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b + GDP-beta-L-fucose <=> ganglioside Fuc-GD1b + GDP + H(+)
REACT:R-XTR-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Xenopus tropicalis)
REACT:R-HSA-5654224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds PLCG1 (Homo sapiens)
REACT:R-XTR-8866405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)
REACT:R-BTA-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Bos taurus)
RHEA:42134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocardicin C => isonocardicin C
REACT:R-HSA-190168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMBL spontaneously transforms to URO1 (Homo sapiens)
RHEA:51044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate imine dimer = CO2 + NH4(+) + protodeoxyviolaceinate
RHEA:22563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-vestitone + NADP(+) <=> 2'-hydroxyformononetin + 2 H(+) + NADPH
RHEA:30836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose
RHEA:57262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP
RHEA:47438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(7Z-hexadecenoyl)-CoA => (2E,7Z)-hexadecadienoyl-CoA + H2O
REACT:R-DME-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Drosophila melanogaster)
RHEA:35161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O
RHEA:25597	skos:altLabel	"6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase"
RHEA:25597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate
RHEA:25597	skos:prefLabel	"2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase"
RHEA:25597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase"
RHEA:25597	skos:altLabel	"SHCHC synthase"
RHEA:25597	skos:altLabel	"2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase"
RHEA:41897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-[ACP] + H(+) + NADPH => NADP(+) + tetradecanoyl-[ACP]
REACT:R-BTA-8852874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 binds C3d, C3dg, iC3b (Bos taurus)
REACT:R-MMU-380869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked dopamine loaded synaptic vesicle (Mus musculus)
RHEA:28879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out)
RHEA:21700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
RHEA:21700	skos:prefLabel	"acireductone synthase"
RHEA:21700	skos:altLabel	"E-1 enolase-phosphatase"
RHEA:21700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acireductone synthase"
REACT:R-MMU-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Mus musculus)
REACT:R-MMU-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Mus musculus)
RHEA:31228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine => di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP
RHEA:69843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in RNA + NAD(+) = a uridine in RNA + H(+) + NADH
REACT:R-HSA-202717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of CEACAMs (Homo sapiens)
REACT:R-CFA-6805035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds STK11 and NUAK1 (Canis familiaris)
RHEA:43087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(34) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-168933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of phosphorylated IRF3/IRF7 (Rattus norvegicus)
REACT:R-SPO-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Schizosaccharomyces pombe)
RHEA:11256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limonoid glucosyltransferase"
RHEA:11256	skos:altLabel	"LGTase"
RHEA:11256	skos:altLabel	"limonoid UDP-glucosyltransferase"
RHEA:11256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + limonin + UDP-alpha-D-glucose = glucosyl-limonin + 2 H(+) + UDP
RHEA:11256	skos:prefLabel	"limonoid glucosyltransferase"
RHEA:22103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dibromo-4-hydroxybenzonitrile + 2 H2O <=> 3,5-dibromo-4-hydroxybenzoate + NH4(+)
RHEA:38034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2
REACT:R-GGA-2028629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Gallus gallus)
RHEA:29243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinone-8 + NADH = menaquinol-8 + NAD(+)
REACT:R-SSC-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Sus scrofa)
REACT:R-HSA-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Homo sapiens)
RHEA:56103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-DRE-5624127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome target cargo to the primary cilium (Danio rerio)
REACT:R-CEL-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Caenorhabditis elegans)
RHEA:15482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O => (6S)-5,6,7,8-tetrahydrofolate + L-serine
REACT:R-CFA-8866542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
RHEA:30238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + L-glutamate + NADH
REACT:R-CFA-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Canis familiaris)
RHEA:70652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]
REACT:R-XTR-428749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-proten Gq (Xenopus tropicalis)
RHEA:49220	skos:prefLabel	"3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase"
RHEA:49220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase"
RHEA:49220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP = CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate
RHEA:27629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + D-xylulose 5-phosphate <=> beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate
REACT:R-GGA-6806957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET receptor dimerizes (Gallus gallus)
REACT:R-MMU-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Mus musculus)
RHEA:52059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hexadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + hexadecanoate
REACT:R-BTA-374337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apelin receptor binds to apelin (Bos taurus)
RHEA:31482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol A + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP
REACT:R-CFA-111804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)
REACT:R-SCE-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Saccharomyces cerevisiae)
RHEA:47246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+) => (2R)-3-phosphoglycerate + an NDP-alpha-D-glucose
REACT:R-GGA-75090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR1 homodimer to dsRNA duplex (Gallus gallus)
REACT:R-HSA-193816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Homo sapiens)
RHEA:46266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-BTA-9027273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Bos taurus)
RHEA:42148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine
RHEA:70922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + dopamine(out) + Na(+)(out) <=> chloride(in) + dopamine(in) + Na(+)(in)
RHEA:69104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + L-kynurenine = H2O + kynurenate + L-cysteine
REACT:R-SCE-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Saccharomyces cerevisiae)
RHEA:35534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-phenylalanyl-L-leucyl) + 2 O2 <=> albonoursin + 2 H2O2
RHEA:52332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] = 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]
GO:0102705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine decarboxylase activity
REACT:R-GGA-5689317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the pre-incision complex in GG-NER (Gallus gallus)
RHEA:26180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase"
RHEA:26180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate
RHEA:26180	skos:prefLabel	"N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase"
RHEA:26180	skos:altLabel	"1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase"
RHEA:70813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate + sulfoacetaldehyde => 4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate
RHEA:16313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase"
RHEA:16313	skos:prefLabel	"5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase"
RHEA:16313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)
REACT:R-RNO-4551604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO1 (Rattus norvegicus)
REACT:R-RNO-5682607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Rattus norvegicus)
REACT:R-XTR-8937744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-7Y-RUNX1 (Xenopus tropicalis)
REACT:R-CFA-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Canis familiaris)
REACT:R-XTR-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Xenopus tropicalis)
RHEA:19556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan <=> indole + NH4(+) + pyruvate
REACT:R-DME-5323545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canonical WNT signaling through the atypical receptor RYK (Drosophila melanogaster)
GO:0016248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	channel inhibitor activity
REACT:R-CFA-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Canis familiaris)
RHEA:67411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol
RHEA:17086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxate + A => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2
REACT:R-MMU-418856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 (Mus musculus)
GO:0004960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thromboxane receptor activity
GO:0004960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXA receptor activity
REACT:R-BTA-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Bos taurus)
REACT:R-GGA-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)
REACT:R-GGA-9756138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)
GO:0103033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-galactosidase activity (lactose isomerization)
REACT:R-GGA-5218916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPK2/3 phosphorylates HSP27 (Gallus gallus)
REACT:R-CEL-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Caenorhabditis elegans)
REACT:R-SCE-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Saccharomyces cerevisiae)
REACT:R-SCE-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Saccharomyces cerevisiae)
REACT:R-DRE-8955289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
REACT:R-MMU-201457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP2 binds to the receptor complex (Mus musculus)
REACT:R-MMU-162830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)
RHEA:67660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:10261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mg(2+)(out) => ADP + H(+) + Mg(2+)(in) + phosphate
RHEA:48591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin B4
RHEA:64908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + 2 H2O = CMP + 2 H(+) + 2 phosphate
REACT:R-SSC-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Sus scrofa)
REACT:R-SSC-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Sus scrofa)
REACT:R-SSC-433698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
REACT:R-SSC-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Sus scrofa)
RHEA:48689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine => D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl
REACT:R-DRE-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Danio rerio)
REACT:R-MMU-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Mus musculus)
REACT:R-CFA-110350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of TDG glycosylase by APEX1 at the AP site (Canis familiaris)
RHEA:15450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => 4-maleylacetoacetate + H(+)
REACT:R-DRE-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Danio rerio)
RHEA:38833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine
RHEA:58030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+) => 5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH
RHEA:61160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + UDP-beta-L-rhamnose = H(+) + quercitrin + UDP
REACT:R-HSA-9638127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G6P to G1P (Homo sapiens)
REACT:R-SSC-9021079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs:CAVs translocate to plasma membrane (Sus scrofa)
REACT:R-RNO-3769394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CBY1 (Rattus norvegicus)
RHEA:32801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea(out) => urea(in)
REACT:R-DRE-178208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF2 (Danio rerio)
RHEA:60777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A12 + O2 => CO2 + gibberellin A15 + succinate
RHEA:30681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + D-glucose => D-cellobiose + H2O
GO:0031843	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 neuropeptide Y receptor ligand
GO:0031843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 neuropeptide Y receptor binding
REACT:R-HSA-158251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Homo sapiens)
REACT:R-XTR-9013110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC binds effectors at the plasma membrane (Xenopus tropicalis)
RHEA:48016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-5-nitrocatechol + NADH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite
RHEA:62814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dinapinone A + 2 H2O => 4 monapinone A + O2
RHEA:44231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-decenoate + ATP + CoA <=> 9-decenoyl-CoA + AMP + diphosphate
REACT:R-MMU-444661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR2 binds HCAR2 ligands (Mus musculus)
REACT:R-HSA-379861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)
REACT:R-BTA-5662986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds copper (Bos taurus)
REACT:R-HSA-5654637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
REACT:R-GGA-4420153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds PLCG1 (Gallus gallus)
GO:0000121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol-1-phosphate phosphohydrolase activity
GO:0000121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glycerophosphatase activity
GO:0000121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol 3-phosphate phosphohydrolase activity
GO:0000121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol-3-phosphate phosphatase activity
GO:0000121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-1-phosphatase activity
GO:0000121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol 3-phosphatase activity
GO:0000121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glycerol phosphatase activity
REACT:R-DRE-8944230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Danio rerio)
RHEA:61166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP => kaempferol + UDP-beta-L-rhamnose
REACT:R-DME-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Drosophila melanogaster)
RHEA:20028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A3 + UDP-alpha-D-glucose <=> gibberellin A3 O-beta-D-glucoside + H(+) + UDP
REACT:R-DRE-9733292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind pramlintide (Danio rerio)
RHEA:16483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine => 3 S-adenosyl-L-methionine
REACT:R-CFA-975122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Canis familiaris)
GO:0034228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine transmembrane transporter activity
GO:0034228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine permease activity
GO:0034228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoethanol transmembrane transporter activity
GO:0034228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine(in) = ethanolamine(out)
GO:0034228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoethanolamine transmembrane transporter activity
REACT:R-HSA-9612516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1 gene expression (Homo sapiens)
GO:0008677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantoate 2-reductase activity
GO:0008677	skos:prefLabel	"2-dehydropantoate 2-reductase"
GO:0008677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ketopantoate reductase activity
GO:0008677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketopantoic acid reductase activity
GO:0008677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxopantoate reductase activity
GO:0008677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KPA reductase activity
GO:0008677	skos:altLabel	"ketopantoate reductase"
GO:0008677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH
GO:0008677	skos:altLabel	"ketopantoic acid reductase"
GO:0008677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-pantoate:NADP+ 2-oxidoreductase activity
GO:0008677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydropantoate 2-reductase"
GO:0008677	skos:altLabel	"KPA reductase"
GO:0008677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketopantoate reductase activity
GO:0008677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ketopantoic acid reductase activity
RHEA:16969	skos:altLabel	"dTDP-L-rhamnose synthetase"
RHEA:16969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose
RHEA:16969	skos:prefLabel	"dTDP-4-dehydrorhamnose 3,5-epimerase"
RHEA:16969	skos:altLabel	"thymidine diphospho-4-ketorhamnose 3,5-epimerase"
RHEA:16969	skos:altLabel	"dTDP-4-keto-6-deoxyglucose 3,5-epimerase"
RHEA:16969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-dehydrorhamnose 3,5-epimerase"
RHEA:25834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + scyllo-inosine => 1D-chiro-inositol + NAD(+)
REACT:R-RNO-8866941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MID1IP1 binds THRSP (Rattus norvegicus)
REACT:R-BTA-9645520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Bos taurus)
REACT:R-CFA-8863101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPPL2a/b cleaves TNF(1-76) (Canis familiaris)
REACT:R-SCE-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Saccharomyces cerevisiae)
RHEA:61255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-valine + O2 <=> 3-methyl-2-oxobutanoate + H2O2 + NH4(+)
REACT:R-RNO-432295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI binds Fyn and Lyn (Rattus norvegicus)
RHEA:30504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-glutamate 5-semialdehyde => acetate + L-glutamate 5-semialdehyde
REACT:R-DME-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Drosophila melanogaster)
RHEA:41525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + 5 malonyl-CoA => 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol
RHEA:62812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 monapinone A + O2 = 2 dinapinone A + 2 H2O
RHEA:68087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-histidyl-[RNA ligase] <=> diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]
REACT:R-XTR-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-GGA-176101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Rad17-RFC complex to DNA (Gallus gallus)
GO:0034283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-stemodene synthase activity
GO:0034283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stemodene synthase activity
GO:0034283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming] activity
GO:0034283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syn-stemod-13(17)-ene synthase activity
GO:0034283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syn-stemodene synthase activity
GO:0034283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stemod-13(17)-ene synthase activity
REACT:R-RNO-9620456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sGC stimulators bind sGC:NO (Rattus norvegicus)
RHEA:52100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)
REACT:R-BTA-6808487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
GO:0050505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone glucosyltransferase activity
GO:0050505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroquinone:O-glucosyltransferase activity
GO:0050505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arbutin synthase activity
GO:0050505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity
GO:0050505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity
GO:0019865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	immunoglobulin binding
REACT:R-SPO-70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Schizosaccharomyces pombe)
REACT:R-MMU-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Mus musculus)
RHEA:42033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate
RHEA:63228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate
REACT:R-SSC-5654582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates SHC1 (Sus scrofa)
RHEA:34854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxyadipyl-CoA + NAD(+) <=> 3-oxoadipyl-CoA + H(+) + NADH
REACT:R-SCE-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Saccharomyces cerevisiae)
GO:0010427	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	abscisate binding
GO:0010427	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ABA binding
GO:0010427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisic acid binding
GO:0102625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cirsimaritin 4'-O-methyltransferase activity
REACT:R-HSA-1602473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP1 (Homo sapiens)
RHEA:35961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethoxyfumitremorgin C + 2 H2O + NADP(+) => H(+) + NADPH + O2 + tryprostatin B
RHEA:55757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 => a 2-hydroxyornithine lipid + CO2 + succinate
REACT:R-BTA-6814418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes formation of G-beta:G-gamma heterodimers (Bos taurus)
RHEA:37050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-histidine(out) <=> H(+)(in) + L-histidine(in)
RHEA:45488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]
GO:0046421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MICL
GO:0046421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)
GO:0046421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylisocitrate lyase activity
GO:0046421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity
GO:0046421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylisocitrate lyase activity
RHEA:24389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + uridine => alpha-D-ribose 1-phosphate + uracil
RHEA:52942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => chenodeoxycholate + UDP-alpha-D-glucuronate
RHEA:57971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-193065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Sus scrofa)
GO:0102002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine N-monooxygenase (oxime forming) activity
RHEA:16889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(6)-acetyl-beta-lysine transaminase"
RHEA:16889	skos:altLabel	"N(6)-acetyl-beta-lysine aminotransferase"
RHEA:16889	skos:prefLabel	"N(6)-acetyl-beta-lysine transaminase"
RHEA:16889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 6-acetamido-3-aminohexanoate = 6-acetamido-3-oxohexanoate + L-glutamate
REACT:R-BTA-373750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:ErbB2 (Bos taurus)
GO:0061815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitinyl hydrolase activity, acting on linear ubiquitin
GO:0061815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met1 linkage specific DUB
GO:0061815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type deubiquitinase activity, acting on linear ubiquitin
GO:0061815	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deubiquitinase, acting on linear ubiquitin
GO:0061815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met1-linked polyubiquitin deubiquitinase activity
GO:0061815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linear ubiquitin specific deubiquitinase activity
RHEA:46322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2 => 3beta-hydroxy-chol-5-ene-24-oyl-CoA + A
REACT:R-BTA-2512800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1:ligand is endocytosed (Bos taurus)
RHEA:57368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH = (6R)-NADPHX
RHEA:12916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate + ATP + H(+) <=> (R)-lipoyl-5'-AMP + diphosphate
REACT:R-DRE-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Danio rerio)
RHEA:59073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
REACT:R-GGA-388900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurotensin receptors can bind neurotensins (Gallus gallus)
RHEA:60505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)
REACT:R-BTA-8987084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)
RHEA:67883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + dopamine <=> adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)
RHEA:61743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolmonoside + UDP-alpha-D-glucose <=> H(+) + steviolbioside + UDP
REACT:R-HSA-8851018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A1 binds DC-SIGN (Homo sapiens)
REACT:R-HSA-9011941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive BCL2 gene expression (Homo sapiens)
REACT:R-XTR-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)
RHEA:21950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + NH4(+) => formamide + H2O
RHEA:10417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + toluene => 2-benzylsuccinate
RHEA:36336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + H2O + NAD(+) => D-glucarate + 2 H(+) + NADH
RHEA:46774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:30643	skos:prefLabel	"S-methyl-5'-thioinosine phosphorylase"
RHEA:30643	skos:altLabel	"methylthioinosine phosphorylase"
RHEA:30643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-methyl-5'-thioinosine phosphorylase"
RHEA:30643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + S-methyl-5'-thioinosine = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
RHEA:30643	skos:altLabel	"MTI phosphorylase"
REACT:R-CEL-1861789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Caenorhabditis elegans)
REACT:R-DME-9012036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)
REACT:R-HSA-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)
REACT:R-DRE-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Danio rerio)
REACT:R-DDI-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Dictyostelium discoideum)
REACT:R-DME-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Drosophila melanogaster)
REACT:R-HSA-427645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A3 cotransports Pi, 2Na+ (Homo sapiens)
REACT:R-CFA-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Canis familiaris)
RHEA:44379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)
REACT:R-CFA-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Canis familiaris)
REACT:R-RNO-417890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y5 receptor can bind to LPA (Rattus norvegicus)
REACT:R-HSA-3361751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)
RHEA:39572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:22217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + O2 => 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)
REACT:R-PFA-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Plasmodium falciparum)
RHEA:11658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-prolyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-proline
REACT:R-SSC-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Sus scrofa)
REACT:R-HSA-9698844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds HSP90:CDC37 (Homo sapiens)
RHEA:58719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + NADH + rifampicin <=> FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal
REACT:R-DME-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Drosophila melanogaster)
REACT:R-PFA-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Plasmodium falciparum)
REACT:R-SCE-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Saccharomyces cerevisiae)
RHEA:42362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-fructose => D-allulose
REACT:R-HSA-8864466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression (Homo sapiens)
RHEA:29105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+)(out) + menaquinol-8 + NAD(+) => 5 H(+)(in) + menaquinone-8 + NADH
REACT:R-SSC-174121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Securin with Cdc20:APC/C complex (Sus scrofa)
GO:0004934	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class D GPCR activity
GO:0004934	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class D G protein coupled receptor activity
GO:0004934	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class D G-protein-coupled receptor activity
GO:0004934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mating-type alpha-factor pheromone receptor activity
GO:0004934	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class D G-protein coupled receptor activity
REACT:R-HSA-9728729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAS1R2:TAS1R3:sweet compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R2:TAS1R3:sweet compound, GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)
REACT:R-CEL-437139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT6 transports zinc into the golgi apparatus (Caenorhabditis elegans)
RHEA:33769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-CoA + H2O => a 3-hydroxy-fatty acyl-CoA
REACT:R-SSC-71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Sus scrofa)
RHEA:21104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholesterol 25-monooxygenase"
RHEA:21104	skos:prefLabel	"cholesterol 25-monooxygenase"
RHEA:21104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O
RHEA:21104	skos:altLabel	"cholesterol 25-hydroxylase"
REACT:R-HSA-5250930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH recruits histone acetyltransferases (Homo sapiens)
REACT:R-DRE-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Danio rerio)
RHEA:32470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + sarcosine <=> glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:45357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(11Z-eicosenoyl)-sphing-4-enine => (11Z)-eicosenoate + sphing-4-enine
GO:0102787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity
REACT:R-BTA-199032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADCAM1-1 binds Integrin alpha4beta7 (Bos taurus)
REACT:R-GGA-8936584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)
REACT:R-XTR-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Xenopus tropicalis)
REACT:R-MMU-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Mus musculus)
REACT:R-XTR-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-HSA-8987141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Homo sapiens)
RHEA:23791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + holo-[citrate lyase ACP] <=> acetyl-[citrate lyase ACP] + AMP + diphosphate
RHEA:53511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione <=> (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate
GO:0047372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoglyceride hydrolase activity
GO:0047372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoacylglycerolipase activity
GO:0047372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylglycerol lipase activity
GO:0047372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoacylglycerol hydrolase activity
GO:0047372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoglyceride lipase activity
GO:0047372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acyl monoester lipase activity
GO:0047372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol-ester acylhydrolase activity
GO:0047372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoglyceridyllipase activity
GO:0047372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoacylglycerol lipase activity
GO:0047372	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoglyceridase activity
REACT:R-DRE-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Danio rerio)
RHEA:37493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine => 4-coumaroyl-CoA + S-adenosyl-L-methionine
REACT:R-PFA-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Plasmodium falciparum)
RHEA:23483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylene-3-methylsuccinate <=> dimethylmaleate
GO:0031492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleosomal DNA binding
RHEA:72814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)
REACT:R-DME-5362459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)
REACT:R-HSA-6811411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the Golgi (Homo sapiens)
RHEA:60445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteinylglycine + H2O => an S-substituted L-cysteine + glycine
EC:5.5.-.-	skos:prefLabel	"Intramolecular lyases"
EC:5.5.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Intramolecular lyases"
RHEA:36474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate(out) + H(+)(out) <=> 3,4,5-trihydroxybenzoate(in) + H(+)(in)
RHEA:18438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol + ATP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)
REACT:R-XTR-2186643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEN1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
REACT:R-RNO-5621347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)
RHEA:52755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isomaltose <=> beta-D-glucose + D-glucose
GO:0015026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity
GO:0015026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity
GO:0015026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity
REACT:R-SSC-390595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Troponin-C (Sus scrofa)
REACT:R-HSA-9694576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)
RHEA:11335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + RNA(n) <=> diphosphate + RNA(n)-3'-adenine ribonucleotide
REACT:R-DME-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Drosophila melanogaster)
RHEA:63271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:44011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-methyl-branched fatty aldehyde + H2O + NAD(+) <=> a 2-methyl fatty acid + 2 H(+) + NADH
REACT:R-CEL-379044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gs-activating GPCR acts as a GEF for Gs (Caenorhabditis elegans)
RHEA:34568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-paratose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH
REACT:R-DME-198266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)
REACT:R-BTA-200396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Creatine transport across the plasma membrane (Bos taurus)
REACT:R-RNO-1296024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in neuroendocrine cells (Rattus norvegicus)
RHEA:18668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) <=> (2R)-3-phosphoglycerate + [phosphate](n+1)
REACT:R-HSA-159836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
REACT:R-RNO-2127257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Rattus norvegicus)
RHEA:59418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + indole-3-acetaldehyde + NH4(+) => H2O + O2 + tryptamine
REACT:R-PFA-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Plasmodium falciparum)
REACT:R-SCE-9733403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds PCSK9 inhibitors (Saccharomyces cerevisiae)
RHEA:64057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-ephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
REACT:R-BTA-9749471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
REACT:R-SCE-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)
REACT:R-XTR-8953013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 binds E2F8 (Xenopus tropicalis)
REACT:R-XTR-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Xenopus tropicalis)
REACT:R-DRE-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Danio rerio)
REACT:R-XTR-8874080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates PTK2 (Xenopus tropicalis)
RHEA:37163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-DRE-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Danio rerio)
REACT:R-RNO-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)
RHEA:12990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + H2O => a dolichyl phosphate + D-mannose + H(+)
GO:0034547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-cyclopropylmelamine deaminase activity
RHEA:43814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-8954513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAA translocates from mitochondrial matrix to cytosol (Homo sapiens)
REACT:R-BTA-5678315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Bos taurus)
RHEA:38758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-2029273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to p-6Y-SYK (Xenopus tropicalis)
REACT:R-HSA-9014342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
RHEA:71045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(out) + L-phenylalanine(in) => L-alanine(in) + L-phenylalanine(out)
REACT:R-RNO-5246478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOM binds retinoids (Rattus norvegicus)
REACT:R-DDI-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Dictyostelium discoideum)
REACT:R-DRE-5665748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds RHOC:GTP (Danio rerio)
REACT:R-HSA-1168633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)
REACT:R-SSC-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Sus scrofa)
RHEA:66071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-leucine
RHEA:10650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexan-6-olide + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + H(+) + NADPH + O2
RHEA:47313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisoheptadecanoyl-CoA = (2E)-15-methylhexadecenoyl-CoA + H2O
GO:0004363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
GO:0004363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GSH synthetase activity
GO:0004363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione synthase activity
GO:0004363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione synthetase activity
REACT:R-DRE-6807826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDHAL6B reduces PYR to LACT (Danio rerio)
GO:0050506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG:vomilenine 21beta-D-glucosyltransferase activity
GO:0050506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG:vomilenine 21-beta-D-glucosyltransferase activity
GO:0050506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity
GO:0050506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vomilenine glucosyltransferase activity
GO:0050506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vomilenine-glucosyltransferase activity
RHEA:38803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine
REACT:R-DRE-917693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESCRT Disassembly (Danio rerio)
RHEA:12196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O
RHEA:12196	skos:altLabel	"D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating)"
RHEA:12196	skos:prefLabel	"fructose-6-phosphate phosphoketolase"
RHEA:12196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructose-6-phosphate phosphoketolase"
RHEA:51527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-corytuberine + S-adenosyl-L-methionine <=> magnoflorine + S-adenosyl-L-homocysteine
REACT:R-BTA-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Bos taurus)
REACT:R-CFA-202706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha4beta1 binds JAM2:JAM3 (Canis familiaris)
RHEA:67661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:11903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-homoisocitrate + NAD(+) <=> 2-oxoadipate + CO2 + NADH
RHEA:29172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + 2 O2 => a ubiquinone + 2 H(+) + 2 superoxide
REACT:R-DRE-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Danio rerio)
REACT:R-HSA-9726875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCNs:cAMP bind SNIs (Homo sapiens)
REACT:R-HSA-453356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGB dimer, b form + 2 AMP <=> PYGB b dimer:AMP complex (Homo sapiens)
RHEA:23213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-alanine => acetate + beta-alanine
RHEA:13739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alk-2-enal + H(+) + NADPH => an n-alkanal + NADP(+)
EC:3.4.21.97	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"assemblin"
EC:3.4.21.97	skos:prefLabel	"assemblin"
EC:1.1.1.285	skos:prefLabel	"3''-deamino-3''-oxonicotianamine reductase"
EC:1.1.1.285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3''-deamino-3''-oxonicotianamine reductase"
REACT:R-BTA-158756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Bos taurus)
REACT:R-SPO-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Schizosaccharomyces pombe)
RHEA:45497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]
REACT:R-BTA-2201341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TRAM (TICAM2) (Bos taurus)
RHEA:36884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SCE-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Saccharomyces cerevisiae)
REACT:R-XTR-977629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of C2a/Bb by CR1 (Xenopus tropicalis)
REACT:R-CFA-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Canis familiaris)
REACT:R-SSC-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Sus scrofa)
RHEA:23710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:68721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:17267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate => trans-aconitate
RHEA:49530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+) => (ethylene terephthalate)(n) + H2O
REACT:R-CFA-976743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates plasma Factor H-bound C3b (Canis familiaris)
REACT:R-CFA-727819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 phosphorylates MKK6 (Canis familiaris)
RHEA:39762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:12163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-gluconate + NAD(+) <=> 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH
RHEA:70543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP
GO:0102159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baicalein 7-O-glucuronosyltransferase activity
REACT:R-CFA-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Canis familiaris)
REACT:R-DRE-2128994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Danio rerio)
REACT:R-MMU-2559456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)
REACT:R-DRE-266051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HpETE is dehydrated to LTA4 by ALOX5 (Danio rerio)
RHEA:46872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB
REACT:R-GGA-879562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Gallus gallus)
RHEA:30534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinate sulfoxide + H(+) + NADH <=> biotin + H2O + NAD(+)
RHEA:33080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-6-deoxyfutalosine + H2O => adenine + dehypoxanthine futalosine
RHEA:49729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NADP(+) + violacein
EC:3.4.24.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"astacin"
EC:3.4.24.21	skos:altLabel	"crayfish small-molecule proteinase"
EC:3.4.24.21	skos:prefLabel	"astacin"
EC:3.4.24.21	skos:altLabel	"Astacus proteinase"
REACT:R-BTA-216072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Bos taurus)
REACT:R-DME-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Drosophila melanogaster)
REACT:R-BTA-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Bos taurus)
RHEA:67677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine
RHEA:67247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyglucosone + H2O + NAD(+) <=> 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH
RHEA:37692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-CEL-8848751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds AKT1 (Caenorhabditis elegans)
RHEA:30658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dUMP <=> ADP + dUDP
REACT:R-HSA-5632667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMO dimer binds ARRB and KIF3A (Homo sapiens)
RHEA:51325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 => (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate
REACT:R-XTR-2426566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and CLM7 (Xenopus tropicalis)
RHEA:37147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-5617874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXD4 gene is transcribed (Homo sapiens)
RHEA:68243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) + Na(+)(in) <=> L-methionine(out) + Na(+)(out)
GO:0031490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin DNA binding
REACT:R-DRE-112342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of MAP2K1 by CDK1 (Danio rerio)
RHEA:27915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate
RHEA:22516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + taurocyamine = ADP + H(+) + N-phosphotaurocyamine
RHEA:22516	skos:prefLabel	"taurocyamine kinase"
RHEA:22516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taurocyamine kinase"
RHEA:31313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+) => (2R)-3-phosphoglycerate + ADP-alpha-D-glucose
REACT:R-SCE-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Saccharomyces cerevisiae)
REACT:R-DME-209293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO) (Drosophila melanogaster)
GO:0015243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloheximide transmembrane transporter activity
GO:0015243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cycloheximide transporter activity
RHEA:43265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA => 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proton-exporting ATPase activity, phosphorylative mechanism
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton-transporting ATPase activity
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	proton-exporting ATPase activity
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	P-type H+-exporting ATPase activity
GO:0008553	skos:altLabel	"H(+)-transporting ATPase"
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen-/sodium-translocating ATPase activity
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type proton-exporting transporter activity
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proton transport ATPase activity
GO:0008553	skos:altLabel	"proton-translocating P-type ATPase"
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type H(+)-exporting transporter"
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H+-exporting ATPase activity
GO:0008553	skos:altLabel	"proton transport ATPase"
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogen-exporting ATPase activity
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H+-transporting ATPase
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proton-translocating ATPase activity
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+)(in) + H2O = ADP + 2 H(+)(out) + phosphate
GO:0008553	skos:prefLabel	"P-type H(+)-exporting transporter"
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen exporting ATPase activity, phosphorylative mechanism
GO:0008553	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H+-transporting ATPase activity
GO:0048244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA dioxygenase activity
GO:0048244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Homo sapiens)
GO:0048244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)
GO:0048244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytanoyl-CoA 2-hydroxylase activity
GO:0048244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytanoyl-CoA alpha-hydroxylase activity
GO:0048244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytanoyl-CoA hydroxylase activity
GO:0048244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytanoyl-CoA 2 oxoglutarate dioxygenase activity
REACT:R-HSA-9013889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR3-induced ripoptosome assembly (Homo sapiens)
REACT:R-CFA-1112666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
RHEA:39030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP
REACT:R-HSA-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Homo sapiens)
REACT:R-SSC-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Sus scrofa)
GO:0050442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(n-propyl)-malate synthase activity
GO:0050442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-propylmalate synthase activity
GO:0050442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-propylmalate synthase activity
GO:0050442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-n-propylmalate synthase activity
GO:0050442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)
GO:0050442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity
RHEA:34619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxypentalenate + 2-oxoglutarate + O2 = 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate
RHEA:34619	skos:prefLabel	"1-deoxypentalenic acid 11beta-hydroxylase"
RHEA:34619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-deoxypentalenic acid 11beta-hydroxylase"
REACT:R-BTA-5624956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds INPP5E (Bos taurus)
REACT:R-DRE-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Danio rerio)
REACT:R-DRE-6799431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds HIPK1 (Danio rerio)
RHEA:16949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose
RHEA:16949	skos:altLabel	"myo-inositol 2-dehydrogenase"
RHEA:16949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol 2-dehydrogenase"
RHEA:16949	skos:prefLabel	"inositol 2-dehydrogenase"
REACT:R-BTA-166753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C4 into C4a and C4b (Bos taurus)
RHEA:57234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + methylglyoxal
RHEA:56413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol
REACT:R-RNO-879942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor is activated (Rattus norvegicus)
REACT:R-DME-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Drosophila melanogaster)
GO:0004923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukemia inhibitory factor receptor activity
GO:0004923	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leukemia inhibitory factor receptor beta-protein activity
GO:0004923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIF receptor activity
REACT:R-RNO-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Rattus norvegicus)
REACT:R-SSC-9008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds ESR1:estrogen:TGFA gene (Sus scrofa)
REACT:R-SSC-8952419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs ubiquitinate RUNX3 (Sus scrofa)
RHEA:26256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isopimara-7,15-dienol + NADPH + O2 <=> 2 H2O + isopimara-7,15-dienal + NADP(+)
GO:0047131	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoadipic semialdehyde synthase activity
GO:0047131	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	saccharopin dehydrogenase activity
GO:0047131	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)
GO:0047131	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)
GO:0047131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity
GO:0047131	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)
GO:0047131	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)
REACT:R-BTA-390252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Bos taurus)
RHEA:52694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + H(+) + NADPH => 3-phenyllactate + NADP(+)
REACT:R-CFA-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)
GO:0018564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbazole 1,9a-dioxygenase activity
GO:0018564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbazole 1,9alpha-dioxygenase activity
RHEA:68237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + Na(+)(in) => L-glutamine(out) + Na(+)(out)
RHEA:55337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine => a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:63328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + ATP = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-GGA-187588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Gallus gallus)
RHEA:29549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-glucosamine
RHEA:69976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:64676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoyl-CoA + butan-1-ol = butyl 3-(methylsulfanyl)propanoate + CoA
REACT:R-MMU-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Mus musculus)
REACT:R-BTA-448703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family precursors are cleaved by caspase-1 (Bos taurus)
GO:0102940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phloroglucinol O-methyltransferase activity
GO:1901238	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tungstate transmembrane transporter activity
GO:1901238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled tungstate transmembrane transporter activity
GO:1901238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type tungstate transporter activity
GO:1901238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tungstate transmembrane-transporting ATPase activity
RHEA:51280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-hydroperoxy-(9Z,11E)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-MMU-5218906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 phosphorylates MLKL (Mus musculus)
REACT:R-GGA-159762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)
REACT:R-XTR-4641206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPOs bind LGRs (Xenopus tropicalis)
REACT:R-RNO-2168897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP1 (CD91) binds Hemopexin:heme (Rattus norvegicus)
REACT:R-DME-1250383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Drosophila melanogaster)
RHEA:37861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA
GO:0106145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scopoletin 8-hydroxylase activity
RHEA:27504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-di-O-methyltricetin + S-adenosyl-L-methionine <=> 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-5667008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds RHPN1 or RHPN2 (Bos taurus)
REACT:R-MMU-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Mus musculus)
REACT:R-BTA-9773803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKBKB phosphorylates NF-kappa-B inhibitor  (Bos taurus)
RHEA:49873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid ketone + a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)
REACT:R-SSC-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
REACT:R-XTR-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Xenopus tropicalis)
RHEA:29602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-156723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF20A (MKL2) by phosphorylation (Mus musculus)
RHEA:16628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hydrogen sulfide <=> CoA + thioacetate
REACT:R-HSA-9686980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)
REACT:R-RNO-9615249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBs bind AGRT1 (Rattus norvegicus)
RHEA:52154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-indolylmethyl desulfoglucosinolate + UDP => (Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose
GO:0102494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GA20 2,3-desaturase activity
RHEA:19350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4-dehydropantoate + H2O + NAD(+) => (R)-3,3-dimethylmalate + 2 H(+) + NADH
RHEA:59588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-ornithine = ADP + beta-alanyl-L-ornithine + H(+) + phosphate
RHEA:47822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2
REACT:R-XTR-9013111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GAPs stimulate RHOC GTPase activity (Xenopus tropicalis)
REACT:R-DRE-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Danio rerio)
RHEA:39135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2
REACT:R-XTR-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)
REACT:R-HSA-5602885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL (Homo sapiens)
RHEA:71036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + L-serine(in) => L-phenylalanine(in) + L-serine(out)
GO:0018510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrophloroglucinol:NADP+ oxidoreductase activity
GO:0018510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phloroglucinol reductase activity
GO:0018510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrophloroglucinol + NADP(+) = 1,3,5-trihydroxybenzene + NADPH
GO:0018510	skos:prefLabel	"phloroglucinol reductase"
GO:0018510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phloroglucinol reductase"
RHEA:18101	skos:prefLabel	"cis-dihydroethylcatechol dehydrogenase"
RHEA:18101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-dihydroethylcatechol dehydrogenase"
RHEA:18101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH
RHEA:20691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + H(+) + L-quinate => chlorogenate + H2O
REACT:R-XTR-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Xenopus tropicalis)
RHEA:22066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol + H2O => 5alpha-ergosta-7,22-diene-3beta,5-diol
REACT:R-RNO-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Rattus norvegicus)
RHEA:35518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'''-demalonylsalvianin + malonyl-CoA <=> CoA + salvianin
RHEA:11927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> globoside Gb3Cer (d18:1(4E)) + H(+) + UDP
REACT:R-MMU-5323545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canonical WNT signaling through the atypical receptor RYK (Mus musculus)
REACT:R-DME-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Drosophila melanogaster)
REACT:R-MMU-170977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 is phosphorylated by active TrkA receptor (Mus musculus)
RHEA:30487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-isoleucine = (1E,2S)-2-methylbutanal oxime + CO2 + H2O
REACT:R-BTA-3341343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)
RHEA:57114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:62592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-1,3-glucanase activity
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glucan 1,3-beta-glucosidase activity
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-(1->3)-glucanohydrolase activity
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,3-beta-glucanase activity
GO:0004338	skos:prefLabel	"glucan 1,3-beta-glucosidase"
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-(1->3)-D-glucanase activity
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,3-beta-D-glucanase activity
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo (1->3)-beta-glucanase activity
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-1,3-D-glucanase activity
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1,3-beta-glucan glucohydrolase activity
GO:0004338	skos:altLabel	"exo-1,3-beta-glucosidase"
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,3-beta-glucosidase activity
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,3-glucan exo-hydrolase activity
GO:0004338	skos:altLabel	"exo-1,3-beta-glucanase"
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan 1,3-beta-glucosidase"
GO:0004338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan exo-1,3-beta-glucosidase activity
GO:0070002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamic-type peptidase activity
RHEA:63680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-7,8-diammoniononanoate + CO2 = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)
REACT:R-GGA-6807578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface in the phagosome (Gallus gallus)
RHEA:43475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate
RHEA:65761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:63734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP + zolarsartan O-beta-D-glucuronoside => UDP-alpha-D-glucuronate + zolasartan
REACT:R-XTR-2327746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 aggregation (Xenopus tropicalis)
GO:0047965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoprotein O-fatty-acyltransferase activity
GO:0047965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity
GO:0047965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein acyltransferase activity
REACT:R-DRE-9731931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds selective ERAs (Danio rerio)
REACT:R-BTA-8940959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurolysin degrades neurotensin (Bos taurus)
REACT:R-RNO-1295622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds CBL (Rattus norvegicus)
REACT:R-SSC-9020256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Sus scrofa)
RHEA:34997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnose(out) => L-rhamnose(in)
RHEA:38637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol
RHEA:25222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-cysteate => CO2 + taurine
REACT:R-BTA-204863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang2 (Bos taurus)
RHEA:30457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-geosmin => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O
RHEA:38839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-195378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of VEGF proteins (Rattus norvegicus)
REACT:R-HSA-8940134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 binds FOLA (Homo sapiens)
REACT:R-DRE-1295621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
RHEA:68865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isomaltose => alpha-D-glucose + D-glucose
RHEA:62493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-arginine => AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]
RHEA:54830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + methylamine + NADP(+) => dimethylamine + H(+) + NADPH + O2
REACT:R-XTR-1604722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP9 by proteases (Xenopus tropicalis)
REACT:R-GGA-9610750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Gallus gallus)
REACT:R-CFA-5654608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS bind to PPTN11 (Canis familiaris)
REACT:R-CFA-419002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Canis familiaris)
RHEA:19183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
GO:0097063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadmium ion sensor activity
REACT:R-HSA-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Homo sapiens)
REACT:R-DDI-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Dictyostelium discoideum)
RHEA:22764	skos:altLabel	"polyphosphoinositol lipid 5-phosphatase"
RHEA:22764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoinositide 5-phosphatase"
RHEA:22764	skos:altLabel	"phosphatidylinositol 4,5-bisphosphate phosphatase"
RHEA:22764	skos:altLabel	"diphosphoinositide phosphatase"
RHEA:22764	skos:altLabel	"phosphatidylinositol-bisphosphatase"
RHEA:22764	skos:prefLabel	"phosphoinositide 5-phosphatase"
RHEA:22764	skos:altLabel	"phosphatidyl-inositol-bisphosphate phosphatase"
RHEA:22764	skos:altLabel	"triphosphoinositide phosphatase"
RHEA:22764	skos:altLabel	"inositol triphosphate 5-phosphomonoesterase"
RHEA:22764	skos:altLabel	"IP3 phosphatase"
RHEA:22764	skos:altLabel	"PtdIns(4,5)P2 phosphatase"
RHEA:22764	skos:altLabel	"inositol 1,4,5-triphosphate 5-phosphomonoesterase"
RHEA:22764	skos:altLabel	"type II inositol polyphosphate 5-phosphatase"
RHEA:22764	skos:altLabel	"triphosphoinositide phosphomonoesterase"
RHEA:22764	skos:altLabel	"type II inositol-1,4,5-trisphosphate 5-phosphatase"
RHEA:22764	skos:altLabel	"phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase"
RHEA:22764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
GO:0008744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylulokinase activity
GO:0008744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:L-xylulose 5-phosphotransferase activity
GO:0008744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-xylulokinase (phosphorylating)
GO:0008744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-xylulose kinase activity
GO:0061697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
GO:0061697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glutaryllysine deglutarylase activity
REACT:R-RNO-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Rattus norvegicus)
REACT:R-GGA-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Gallus gallus)
REACT:R-MMU-6783556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIFR:JAKs bind gp130:JAKs:CNTFR (Mus musculus)
RHEA:65287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate <=> 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)
GO:0047683	skos:prefLabel	"carboxylate reductase (NADP(+))"
GO:0047683	skos:altLabel	"aryl-aldehyde dehydrogenase (NADP(+))"
GO:0047683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryl-aldehyde dehydrogenase (NADP+) activity
GO:0047683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aromatic acid reductase activity
GO:0047683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)
GO:0047683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxylate reductase (NADP(+))"
GO:0047683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + an aromatic aldehyde + diphosphate + NADP(+) = an aromatic carboxylate + ATP + H(+) + NADPH
REACT:R-BTA-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Bos taurus)
REACT:R-BTA-2176491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L binds phosphorylated linker region of SMAD2/3 (Bos taurus)
REACT:R-GGA-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Gallus gallus)
REACT:R-SPO-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Schizosaccharomyces pombe)
REACT:R-DRE-354073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PTK2 at Y397 (Danio rerio)
REACT:R-DDI-174105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated cell cycle proteins (Dictyostelium discoideum)
REACT:R-SPO-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Schizosaccharomyces pombe)
REACT:R-GGA-9033491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Gallus gallus)
RHEA:16290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-ephedrine + NAD(+) => (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH
REACT:R-MMU-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Mus musculus)
RHEA:21441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 => a long-chain alkane + formate + H2O + 2 NADP(+)
REACT:R-MMU-3215426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Mus musculus)
RHEA:45895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + CDP-ethanolamine <=> an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)
RHEA:43060	skos:altLabel	"2-O-alpha-D-glucopyranosylglycerol phosphorylase"
RHEA:43060	skos:prefLabel	"1,2-alpha-glucosylglycerol phosphorylase"
RHEA:43060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = beta-D-glucose 1-phosphate + glycerol
RHEA:43060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,2-alpha-glucosylglycerol phosphorylase"
REACT:R-XTR-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Xenopus tropicalis)
REACT:R-BTA-8865774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLLs polyglutamylate tubulin (Bos taurus)
RHEA:29396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UTP => diphosphate + H(+) + UMP
REACT:R-HSA-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Homo sapiens)
RHEA:11429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + O2 => D-glucono-1,5-lactone + H2O2
GO:0102546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosylglycerate hydrolase"
GO:0102546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosylglycerate hydrolase activity
GO:0102546	skos:prefLabel	"mannosylglycerate hydrolase"
GO:0102546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + D-mannose
REACT:R-DRE-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Danio rerio)
REACT:R-DME-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
REACT:R-CEL-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Caenorhabditis elegans)
REACT:R-HSA-8955885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)
REACT:R-SSC-376200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A10-mediated uptake of small neutral amino acids (Sus scrofa)
EC:1.1.1.112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indanol dehydrogenase"
EC:1.1.1.112	skos:prefLabel	"indanol dehydrogenase"
REACT:R-RNO-194308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Rattus norvegicus)
GO:0004852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)
GO:0004852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uroporphyrinogen-III synthase activity
GO:0004852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylbilane hydro-lyase (cyclizing) activity
GO:0004852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	URO-synthase activity
GO:0004852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	porphobilinogenase activity
GO:0004852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen isomerase activity
GO:0004852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen-III cosynthase activity
GO:0004852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen III cosynthase activity
GO:0004852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen-III cosynthetase activity
REACT:R-CEL-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Caenorhabditis elegans)
GO:0047371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyrate-acetoacetate CoA-transferase activity
GO:0047371	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyryl-CoA-acetoacetate CoA-transferase activity
GO:0047371	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butanoyl-CoA:acetoacetate CoA-transferase activity
GO:0047371	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyryl coenzyme A-acetoacetate coenzyme A-transferase activity
GO:0047443	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-4-methyl-2-ketoglutarate aldolase activity
GO:0047443	skos:prefLabel	"4-hydroxy-4-methyl-2-oxoglutarate aldolase"
GO:0047443	skos:altLabel	"CHA aldolase"
GO:0047443	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)
GO:0047443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
GO:0047443	skos:altLabel	"HMG aldolase"
GO:0047443	skos:altLabel	"4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase"
GO:0047443	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity
GO:0047443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-4-methyl-2-oxoglutarate aldolase"
GO:0047443	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate aldolase activity
GO:0047443	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity
GO:0047443	skos:altLabel	"4-carboxy-4-hydroxy-2-oxoadipate aldolase"
RHEA:57438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaethol + O2 + reduced [NADH--hemoprotein reductase]
REACT:R-HSA-170156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes (Homo sapiens)
RHEA:28780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-threonine => glycine + glycolaldehyde
REACT:R-MMU-2473584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP15 (Mus musculus)
RHEA:52588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH
RHEA:34670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + S-adenosyl-L-methionine <=> 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
RHEA:33037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-5591052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROCR binds Protein C (Gallus gallus)
RHEA:55441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Rattus norvegicus)
REACT:R-SCE-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Saccharomyces cerevisiae)
RHEA:46838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:38905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin(out) + ADP + H(+) + phosphate => a sphingomyelin(in) + ATP + H2O
RHEA:63675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH <=> H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)
RHEA:25115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyridoxine 5'-phosphate <=> phosphate + pyridoxine
REACT:R-DDI-1482827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Dictyostelium discoideum)
REACT:R-CEL-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Caenorhabditis elegans)
REACT:R-DDI-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Dictyostelium discoideum)
RHEA:45134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O
RHEA:37129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + phosphonate + succinate => 2-oxoglutarate + dioxidophosphate + H2O2
GO:0033204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease P RNA binding
GO:0033204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase P RNA binding
GO:0019981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-6 binding
GO:0019981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-6 binding
GO:0090614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-methylthioadenosine deaminase activity
REACT:R-DDI-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Dictyostelium discoideum)
REACT:R-BTA-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
RHEA:36495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + ATP = ADP + alpha-D-glucose 6-phosphate + H(+)
REACT:R-XTR-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Xenopus tropicalis)
REACT:R-DME-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Drosophila melanogaster)
REACT:R-RNO-5686430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81 binds EME1, EME2 (Rattus norvegicus)
REACT:R-RNO-6805573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I/type II heterodimers form tetramers (Rattus norvegicus)
REACT:R-CFA-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Canis familiaris)
RHEA:25512	skos:altLabel	"2-amino-2-deoxyisochorismate synthase"
RHEA:25512	skos:altLabel	"ADIC synthase"
RHEA:25512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-amino-4-deoxychorismate synthase"
RHEA:25512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine
RHEA:25512	skos:prefLabel	"2-amino-4-deoxychorismate synthase"
RHEA:70474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 <=> a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate
REACT:R-XTR-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Xenopus tropicalis)
RHEA:72965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(in) + 2 Na(+)(in) => acetoacetate(out) + 2 Na(+)(out)
RHEA:30025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine 5'-phosphate + pyruvate => L-alanine + pyridoxal 5'-phosphate
REACT:R-RNO-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Rattus norvegicus)
RHEA:20600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-cysteine + NAD(+) <=> H(+) + L-cystine + NADH
REACT:R-CFA-426209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG activation of TRPC channels (Canis familiaris)
RHEA:16000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)
REACT:R-RNO-5693564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with RAD52:DNA double-strand break ends (Rattus norvegicus)
RHEA:14258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)
REACT:R-CEL-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Caenorhabditis elegans)
REACT:R-MMU-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Mus musculus)
RHEA:48159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GQ1b (d18:1(4E)) + H2O <=> ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate
RHEA:46480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-202723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha5beta1 binds FN1 dimer (Homo sapiens)
REACT:R-HSA-6784959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPHL hydrolyses VACV to ACV (Homo sapiens)
RHEA:25393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH => (3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+)
RHEA:57287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA
REACT:R-GGA-433698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
REACT:R-RNO-8948015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Rattus norvegicus)
REACT:R-SSC-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Sus scrofa)
REACT:R-DME-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Drosophila melanogaster)
RHEA:25540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate = diphosphate + ent-pimara-8(14),15-diene
RHEA:25540	skos:prefLabel	"ent-pimara-8(14),15-diene synthase"
RHEA:25540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-pimara-8(14),15-diene synthase"
RHEA:13698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose => ADP + D-ribose 5-phosphate + H(+)
REACT:R-HSA-8948180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxynitrite oxidizes Cys residues (Homo sapiens)
REACT:R-DRE-9681294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6R binds IL6R inhibitors (Danio rerio)
RHEA:40433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-XTR-349657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Xenopus tropicalis)
RHEA:12351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-muconolactone <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate
REACT:R-DME-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Drosophila melanogaster)
REACT:R-MMU-9708558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Mus musculus)
GO:0047045	skos:prefLabel	"testosterone 17beta-dehydrogenase (NADP(+))"
GO:0047045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent testosterone-17beta-oxidoreductase activity
GO:0047045	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	17-ketoreductase activity
GO:0047045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity
GO:0047045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	testosterone 17beta-dehydrogenase (NADP+)
GO:0047045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"testosterone 17beta-dehydrogenase (NADP(+))"
GO:0047045	skos:altLabel	"17-ketoreductase"
GO:0047045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH
RHEA:33938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide
REACT:R-MMU-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Mus musculus)
REACT:R-RNO-2160935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 ubiquitinates RHOA (Rattus norvegicus)
REACT:R-CFA-8944232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XII (Canis familiaris)
REACT:R-MMU-2162226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Mus musculus)
REACT:R-XTR-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Xenopus tropicalis)
REACT:R-HSA-8852317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GTSE1 (Homo sapiens)
REACT:R-HSA-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Homo sapiens)
REACT:R-BTA-5218851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Bos taurus)
RHEA:12027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-sinapoyl)-beta-D-glucose + choline <=> D-glucose + O-sinapoylcholine
RHEA:20461	skos:prefLabel	"ornithine lipid N-methyltransferase"
RHEA:20461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ornithine lipid N-methyltransferase"
RHEA:20461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-RNO-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Rattus norvegicus)
REACT:R-RNO-975902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)
RHEA:39897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganate + H(+) + UDP => 7-deoxyloganetate + UDP-alpha-D-glucose
REACT:R-DRE-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Danio rerio)
REACT:R-HSA-2545203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cleaved cohesin (Homo sapiens)
REACT:R-DRE-5691411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Danio rerio)
REACT:R-XTR-453183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y348-SYK dissociates (Xenopus tropicalis)
RHEA:10603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 <=> prostaglandin D2
RHEA:10678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopropylmaleate + H2O => (2R,3S)-3-isopropylmalate
RHEA:10429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
REACT:R-DRE-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Danio rerio)
REACT:R-GGA-976743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates plasma Factor H-bound C3b (Gallus gallus)
REACT:R-BTA-202710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MERTK receptor binds ligands (Gas6 or Protein S) (Bos taurus)
GO:0019160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide-nucleotide phosphoribohydrolase activity
GO:0019160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NMNGhase activity
GO:0019160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide mononucleotide nucleosidase activity
GO:0019160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide mononucleotidase activity
GO:0019160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NMN glycohydrolase activity
GO:0019160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NMNase activity
GO:0019160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMN nucleosidase activity
REACT:R-MMU-5687183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKDC phosphorylates DCLRE1C at DNA DSBs (Mus musculus)
REACT:R-HSA-8850945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates PTEN (Homo sapiens)
RHEA:53284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + scyllo-inosose = 3-dehydro-scyllo-inosose + H(+) + NADH
REACT:R-DRE-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Danio rerio)
REACT:R-GGA-391155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRPA binds SFTPA oligomer, SFTPD oligomer (Gallus gallus)
REACT:R-CEL-9749609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCHE hydrolyzes ASA- (Caenorhabditis elegans)
REACT:R-MMU-2022061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan sulfate can be further sulfated on position 2 of iduronate (Mus musculus)
REACT:R-DRE-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Danio rerio)
RHEA:20989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 2 H2O => AMP + 2 H(+) + 2 phosphate
RHEA:22458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sarcosine + urea => creatine + H2O
RHEA:17751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + quinolin-2(1H)-one => A + H2O + quinoline
GO:0018578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocatechuic 3,4-oxygenase activity
GO:0018578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocatechuic acid oxidase activity
GO:0018578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocatechuic 3,4-dioxygenase activity
GO:0018578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)
GO:0018578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protocatechuate 3,4-dioxygenase activity
GO:0018578	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protocatechuate oxygenase activity
REACT:R-RNO-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Rattus norvegicus)
RHEA:39753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0140849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H2AZ histone exchange activity
GO:0140849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent H2A.Z histone chaperone activity
GO:0140849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent H2AZ histone chaperone activity
REACT:R-XTR-9773803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKBKB phosphorylates NF-kappa-B inhibitor  (Xenopus tropicalis)
GO:0019117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyfluorene dioxygenase activity
REACT:R-RNO-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Rattus norvegicus)
REACT:R-HSA-9008258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 binds ESR1:estrogen:TFGA gene (Homo sapiens)
REACT:R-BTA-352385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Bos taurus)
RHEA:66909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine => 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A
REACT:R-XTR-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Xenopus tropicalis)
RHEA:65331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chrodrimanin F <=> AH2 + chrodrimanin H
RHEA:29582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(in) + H(+)(in) <=> Fe(2+)(out) + H(+)(out)
REACT:R-BTA-8948232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Bos taurus)
REACT:R-CFA-8942208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOXE3 isomerises 12R-HpETE to HXA3 (Canis familiaris)
REACT:R-GGA-5687088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates MAPKAPK5 (Gallus gallus)
REACT:R-MMU-77614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR1) (Mus musculus)
REACT:R-SSC-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Sus scrofa)
REACT:R-MMU-6788999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HV1-mediated H+ transfer (Mus musculus)
RHEA:35218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XDP <=> H(+) + phosphate + XMP
REACT:R-SSC-114263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization  of BAK at the mitochondrial membrane (Sus scrofa)
REACT:R-SSC-4754181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me2K5-histone H3 (Sus scrofa)
REACT:R-SSC-114670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binds to vWF:Collagen complex (Sus scrofa)
REACT:R-XTR-204850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Dok-2 (Xenopus tropicalis)
REACT:R-CEL-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Caenorhabditis elegans)
REACT:R-XTR-375151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with collagens (Xenopus tropicalis)
RHEA:45385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-DME-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Drosophila melanogaster)
REACT:R-SCE-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)
REACT:R-XTR-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-RNO-420584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin 3 trans heterodimer interaction (Rattus norvegicus)
RHEA:50428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine
RHEA:50428	skos:prefLabel	"methanethiol S-methyltransferase"
RHEA:50428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methanethiol S-methyltransferase"
REACT:R-CFA-163741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Canis familiaris)
REACT:R-SSC-2473184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follistatin (FST) binds Activin (Sus scrofa)
RHEA:62210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:56160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosyl-dolichyl phosphate glucuronosyltransferase"
RHEA:56160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate = an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP
RHEA:56160	skos:prefLabel	"glucosyl-dolichyl phosphate glucuronosyltransferase"
RHEA:16623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + sanguinarine => dihydrosanguinarine + H(+) + O2
REACT:R-HSA-9626848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Homo sapiens)
RHEA:23583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 <=> prostaglandin I2
RHEA:29960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
REACT:R-GGA-5218824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds FYN (Gallus gallus)
RHEA:65155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + UDP-alpha-D-glucose <=> (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-RNO-442368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
REACT:R-CFA-5617828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIP11:IFT20 dissociates (Canis familiaris)
RHEA:61123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:63191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + AH2 + tyramine <=> A + H2O + norbelladine
RHEA:48698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O
RHEA:65131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:62561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + A + H2O => (4R)-perillyl alcohol + AH2
RHEA:30179	skos:prefLabel	"oxalate oxidoreductase"
RHEA:30179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate + oxidized 2[4Fe-4S]-[ferredoxin] = 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:30179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxalate oxidoreductase"
REACT:R-GGA-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Gallus gallus)
RHEA:56156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-MMU-354073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PTK2 at Y397 (Mus musculus)
RHEA:36416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-MMU-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Mus musculus)
RHEA:43516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-5-formylfuran + H2O = 2-carboxy-5-(dihydroxymethyl)furan
REACT:R-MMU-75872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Mus musculus)
REACT:R-GGA-2730847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP2 by PLCG (Gallus gallus)
REACT:R-SPO-5653766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)
REACT:R-DRE-196126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from cytosol to mitochondrial intermembrane space (Danio rerio)
REACT:R-MMU-350319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of vimentin at IDVD (259) (Mus musculus)
RHEA:63641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+) => 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-DRE-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Danio rerio)
REACT:R-CFA-111742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)
REACT:R-SCE-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Saccharomyces cerevisiae)
RHEA:35018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin(in) <=> riboflavin(out)
GO:0008266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(U) binding
GO:0008266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(U) RNA binding
REACT:R-SSC-5693742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH hydrolyses AEA to AA and ETA (Sus scrofa)
RHEA:11168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxypimeloyl-CoA dehydrogenase"
RHEA:11168	skos:prefLabel	"3-hydroxypimeloyl-CoA dehydrogenase"
RHEA:11168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) = 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH
RHEA:47955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O <=> [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)
RHEA:39472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)
REACT:R-CFA-4720446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Canis familiaris)
REACT:R-HSA-71287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphocreatine + H2O => creatinine + orthophosphate (Homo sapiens)
RHEA:48063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose
REACT:R-DDI-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Dictyostelium discoideum)
RHEA:63008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+)
REACT:R-RNO-879934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SHC1 is mediated by Y593 of the common beta chain (Rattus norvegicus)
REACT:R-GGA-168921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIF:activated TLR3/TLR4 complex recruits RIP1 (Gallus gallus)
RHEA:31303	skos:prefLabel	"flavin reductase (NADH)"
RHEA:31303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavin reductase (NADH)"
RHEA:31303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a reduced flavin + NAD(+) = an oxidized flavin + 2 H(+) + NADH
RHEA:31303	skos:altLabel	"NADH-dependent flavin reductase"
RHEA:36534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA <=> (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA
REACT:R-CFA-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Canis familiaris)
GO:0052579	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-isomenthone:NADP+ oxidoreductase activity
GO:0052579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-pulegone reductase, (+)-isomenthone as substrate, activity
REACT:R-DRE-6804441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF34 or RFFL ubiquitinates phosphorylated TP53 (Danio rerio)
EC:6.3.2.n3	skos:altLabel	"ISG15-conjugating enzyme"
EC:6.3.2.n3	skos:prefLabel	"ISG15--protein ligase"
EC:6.3.2.n3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ISG15--protein ligase"
RHEA:58615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-octanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine
RHEA:41155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+)
REACT:R-GGA-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Gallus gallus)
REACT:R-DRE-9033516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Danio rerio)
REACT:R-DME-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Drosophila melanogaster)
GO:0098821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP receptor activity
REACT:R-BTA-379044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)
REACT:R-XTR-1605723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Xenopus tropicalis)
RHEA:27479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + neopinone + succinate => 2-oxoglutarate + O2 + thebaine
RHEA:18543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine => 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine
RHEA:32550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (1R,5R)-sabinene + diphosphate
REACT:R-HSA-265423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Fibrillin (Homo sapiens)
REACT:R-DRE-191422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate-5-phosphate is further phosphorylated. (Danio rerio)
REACT:R-CFA-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)
REACT:R-CEL-5666216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds TAX1BP3 (Caenorhabditis elegans)
REACT:R-SSC-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Sus scrofa)
REACT:R-SSC-174447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation on the C-strand of the telomere (Sus scrofa)
REACT:R-DME-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Drosophila melanogaster)
REACT:R-DME-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Drosophila melanogaster)
GO:0140805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]
GO:0140805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-protein-serine ADP-ribosyltransferase activity
REACT:R-RNO-193497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Rattus norvegicus)
RHEA:16219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arabinonate => H2O + L-arabinono-1,4-lactone
RHEA:16355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + sulfoacetaldehyde => 2-oxoglutarate + taurine
RHEA:46891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2
RHEA:25285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + squalene <=> (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-199062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLRC1:KLRD1 heterodimer interacts with HLA-E (Homo sapiens)
REACT:R-DRE-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Danio rerio)
RHEA:25532	skos:prefLabel	"ent-cassa-12,15-diene synthase"
RHEA:25532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-cassa-12,15-diene synthase"
RHEA:25532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate = diphosphate + ent-cassa-12,15-diene
REACT:R-DME-193711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
GO:0015360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen:acetate symporter activity
GO:0015360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate:hydrogen symporter activity
GO:0015360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate:proton symporter activity
REACT:R-HSA-199043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LILRs interact with MHC Class I (Homo sapiens)
GO:0047179	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity
GO:0047179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF acetyltransferase activity
GO:0047179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	platelet-activating factor acetyltransferase activity
REACT:R-XTR-352052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Xenopus tropicalis)
RHEA:72534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + methyl beta-D-galactoside(out) <=> ADP + H(+) + methyl beta-D-galactoside(in) + phosphate
REACT:R-CEL-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
REACT:R-CFA-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Canis familiaris)
REACT:R-DME-4570463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Drosophila melanogaster)
RHEA:59273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine => D-cysteine
RHEA:42097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamoyl phosphate + H2O + tobramycin => AMP + diphosphate + H(+) + nebramycin 5' + phosphate
RHEA:41565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklavinone + dTDP-beta-L-rhodosamine => aclacinomycin T + dTDP + 2 H(+)
REACT:R-BTA-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Bos taurus)
RHEA:26129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate => diphosphate + isopimara-7,15-diene
REACT:R-HSA-9009485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34:CSF1 binds CSF1R (Homo sapiens)
RHEA:70212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose => (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose
REACT:R-HSA-9618407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the ARL4C gene (Homo sapiens)
REACT:R-XTR-5654399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS2 (Xenopus tropicalis)
REACT:R-HSA-879942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor is activated (Homo sapiens)
RHEA:50430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine => methanethiol + S-adenosyl-L-methionine
RHEA:66225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-C9-CoA + O2 => asc-DeltaC9-CoA + H2O2
GO:0018749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dichlorophenylurea)acetate amidohydrolase activity
REACT:R-XTR-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Xenopus tropicalis)
RHEA:39940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
RHEA:11602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CDP => ATP + CMP
REACT:R-GGA-982775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor dimerizes (Gallus gallus)
EC:3.4.23.52	skos:prefLabel	"preflagellin peptidase"
EC:3.4.23.52	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"preflagellin peptidase"
REACT:R-HSA-8857565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)
RHEA:30797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + glutaryl-CoA + NADH => 2-oxoadipate + CoA + NAD(+)
RHEA:53176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)
RHEA:50433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + prostaglandin G1 => A + H2O + prostaglandin H1
REACT:R-MMU-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Mus musculus)
REACT:R-CEL-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Caenorhabditis elegans)
GO:0008933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lytic transglycosylase activity
GO:0008933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan lytic transglycosylase activity
GO:0008933	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	murein transglycosylase B activity
REACT:R-BTA-450333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)
REACT:R-BTA-202214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)
RHEA:30981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-3,4-didehydrolycopene => A + all-trans-lycopene
REACT:R-DRE-212706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipase C-gamma1 binds to the activated EGF receptor (Danio rerio)
RHEA:42110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + progesterone => (20S)-hydroxypregn-4-en-3-one + NAD(+)
REACT:R-CEL-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Caenorhabditis elegans)
REACT:R-XTR-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Xenopus tropicalis)
REACT:R-CFA-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Canis familiaris)
RHEA:36049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + AH2 + H(+) => A + D-glyceraldehyde + H2O
REACT:R-SCE-109863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK3:MAP2K1 (Saccharomyces cerevisiae)
RHEA:69784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminophenyl)succinate + succinyl-CoA => 2-(2-aminophenyl)succinyl-CoA + succinate
REACT:R-SSC-9011543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCA binds PDK2 (Sus scrofa)
REACT:R-XTR-9661723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)
RHEA:15656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 2,6-bisphosphate + H(+)
GO:0050117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-beta-alanine amidohydrolase activity
GO:0050117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-alanine deacetylase activity
RHEA:18102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydro-3-ethylcatechol + NAD(+) => 3-ethylcatechol + H(+) + NADH
REACT:R-MMU-2022403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)
RHEA:64773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol
REACT:R-RNO-5684801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)
RHEA:22957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
EC:2.7.1.45	skos:altLabel	"3-deoxy-2-oxo-D-gluconate kinase"
EC:2.7.1.45	skos:altLabel	"2-keto-3-deoxygluconokinase"
EC:2.7.1.45	skos:prefLabel	"2-dehydro-3-deoxygluconokinase"
EC:2.7.1.45	skos:altLabel	"KDG kinase"
EC:2.7.1.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxygluconokinase"
REACT:R-DDI-3076905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular BTD hydrolyses BCTN (Dictyostelium discoideum)
REACT:R-RNO-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)
RHEA:35114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-L-idonate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH
RHEA:57043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-apiose <=> D-apiofuranose
REACT:R-BTA-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Bos taurus)
RHEA:40887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + octadecanoate + sn-glycerol 3-phosphocholine
RHEA:14259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose
RHEA:50848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
RHEA:53517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-9728804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 nsp1 binds to PPIase (Homo sapiens)
RHEA:25992	skos:prefLabel	"epi-isozizaene synthase"
RHEA:25992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"epi-isozizaene synthase"
RHEA:25992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate
RHEA:43609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O => 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate
REACT:R-BTA-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Bos taurus)
RHEA:14695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP => a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine
RHEA:46541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-5694082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XK:KEL:Zn2+ cleaves EDN3 (Canis familiaris)
RHEA:28188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + methylglyoxal + NH4(+) => aminoacetone + H2O + O2
REACT:R-XTR-9750666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds ST (Xenopus tropicalis)
REACT:R-BTA-5607043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa associates with cell membrane (Bos taurus)
RHEA:53897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)
REACT:R-HSA-422017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase decanoylates Proghrelin (Homo sapiens)
RHEA:32276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(phosphooxy)-L-threonine + NAD(+) => 3-amino-2-oxopropyl phosphate + CO2 + NADH
REACT:R-CEL-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Caenorhabditis elegans)
RHEA:44750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) => 5-amino-1-(beta-D-ribosyl)imidazole + ATP
RHEA:50252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H(+) + malonyl-CoA = a 3-oxoacyl-CoA + CO2 + CoA
RHEA:34148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-L-scyllo-inosose + L-glutamine => 2-deoxy-scyllo-inosamine + 2-oxoglutaramate
RHEA:39145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+)
GO:0004123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoserine deaminase-cystathionase activity
GO:0004123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
GO:0004123	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	gamma-cystathionase activity
GO:0004123	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-cystathionine cysteine-lyase (deaminating)
GO:0004123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cystathionine gamma-lyase activity
GO:0004123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoserine deaminase activity
GO:0004123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoserine dehydratase activity
GO:0140563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity
REACT:R-RNO-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)
REACT:R-DDI-8944247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VI (Dictyostelium discoideum)
REACT:R-DRE-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Danio rerio)
REACT:R-RNO-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Rattus norvegicus)
RHEA:29737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + FMN + 2 H(+) + H2O + sulfite => butane-1-sulfonate + FMNH2 + O2
REACT:R-XTR-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Xenopus tropicalis)
REACT:R-HSA-2681675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds THBS1 (Homo sapiens)
RHEA:41212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + H(+) + NADH + O2 => 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)
RHEA:20109	skos:altLabel	"ribose 1,5-bisphosphokinase"
RHEA:20109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,5-bisphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP
RHEA:20109	skos:prefLabel	"ribose 1,5-bisphosphate phosphokinase"
RHEA:20109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribose 1,5-bisphosphate phosphokinase"
RHEA:47818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2
REACT:R-CFA-6809309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR6 binds MTMR9 (Canis familiaris)
REACT:R-RNO-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Rattus norvegicus)
RHEA:50404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] = 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]
RHEA:43908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O = D-galactose + sphing-4-enine
GO:0052715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-diinositol phosphorylceramide phospholipase activity
REACT:R-DDI-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)
REACT:R-MMU-429613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-DDI-5658231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs stimulate RAS GTPase activity (Dictyostelium discoideum)
RHEA:18873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-D-alanine + H2O = chloride + H(+) + NH4(+) + pyruvate
RHEA:18873	skos:prefLabel	"3-chloro-D-alanine dehydrochlorinase"
RHEA:18873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-chloro-D-alanine dehydrochlorinase"
REACT:R-SSC-169719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted CD14 binds LPS (Sus scrofa)
RHEA:56027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
REACT:R-MMU-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Mus musculus)
REACT:R-XTR-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-DDI-9753285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)
RHEA:63651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SCE-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Saccharomyces cerevisiae)
RHEA:40906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine
RHEA:67621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:63477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin E2 => 15-oxoprostaglandin E2 + H(+) + NADPH
RHEA:40312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + O2 => (2E)-hexenoyl-CoA + H2O2
RHEA:27330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + urate => 5-hydroxyisourate + H2O + NAD(+)
REACT:R-RNO-213406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from LAT (Rattus norvegicus)
GO:0043836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthine hydrolase activity
GO:0043836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthinase activity
REACT:R-MMU-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Mus musculus)
REACT:R-XTR-6799959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP3,4 binds bacterial peptidoglycan (Xenopus tropicalis)
REACT:R-DDI-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)
RHEA:59203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + docosanoate + H(+) <=> diphosphate + docosanoyl-AMP
RHEA:72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 => 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)
GO:1990601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' overhang single-stranded DNA endodeoxyribonuclease activity
RHEA:43226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:32696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (-)-car-3-ene + diphosphate
REACT:R-BTA-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Bos taurus)
REACT:R-MMU-9024326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Mus musculus)
REACT:R-RNO-170977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 is phosphorylated by active TrkA receptor (Rattus norvegicus)
RHEA:59997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] => (E)-cinnamate + reduced [electron-transfer flavoprotein]
REACT:R-GGA-375768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Gallus gallus)
RHEA:70933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + dopamine(in) + 2 Na(+)(in) => chloride(out) + dopamine(out) + 2 Na(+)(out)
REACT:R-RNO-2872497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-2 transports cytosolic urate to extracellular region (Rattus norvegicus)
REACT:R-HSA-893609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic] (Homo sapiens)
RHEA:50121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-taurine
RHEA:71882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide
REACT:R-SCE-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-HSA-1889978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)
RHEA:10733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + firefly D-luciferin + O2 => AMP + CO2 + diphosphate + firefly oxyluciferin + hnu
REACT:R-RNO-8983870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Rattus norvegicus)
REACT:R-SSC-8943007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Sus scrofa)
REACT:R-CEL-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Caenorhabditis elegans)
REACT:R-CFA-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Canis familiaris)
GO:0016158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phytase activity
GO:0016158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol-hexakisphosphate 3-phosphohydrolase activity
GO:0016158	skos:altLabel	"1-phytase"
GO:0016158	skos:altLabel	"phytase"
GO:0016158	skos:altLabel	"myo-inositol-hexakisphosphate 3-phosphohydrolase"
GO:0016158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytate 3-phosphatase activity
GO:0016158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate
GO:0016158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytate 1-phosphatase activity
GO:0016158	skos:altLabel	"phytate 3-phosphatase"
GO:0016158	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phytase activity
GO:0016158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-phytase"
GO:0016158	skos:altLabel	"phytate 6-phosphatase"
GO:0016158	skos:altLabel	"phytate 1-phosphatase"
GO:0016158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phytase activity
GO:0016158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol-hexaphosphate 3-phosphohydrolase activity
GO:0016158	skos:prefLabel	"3-phytase"
RHEA:12877	skos:altLabel	"diketone cleaving enzyme"
RHEA:12877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylacetone-cleaving enzyme"
RHEA:12877	skos:altLabel	"diketone cleaving dioxygenase"
RHEA:12877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylacetone + O2 = acetate + H(+) + methylglyoxal
RHEA:12877	skos:altLabel	"acetylacetone dioxygenase"
RHEA:12877	skos:prefLabel	"acetylacetone-cleaving enzyme"
RHEA:51938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + hydroquinone => 2-(glutathione-S-yl)-hydroquinone + glutathione
RHEA:40194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH
REACT:R-DME-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)
RHEA:14002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + glycine => CoA + glycocholate + H(+)
REACT:R-SSC-1678998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosomal TLRs pass through the Golgi (Sus scrofa)
RHEA:53077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine => 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+) => (2,5-ethylene furandicarboxylate)(n) + 2 H2O
REACT:R-HSA-4724279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Homo sapiens)
REACT:R-HSA-9665698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)
REACT:R-BTA-74726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of insulin from insulin receptor (Bos taurus)
REACT:R-MMU-9679477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFA inhibitors (Mus musculus)
RHEA:35866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:17501	skos:altLabel	"polyneuridine aldehyde esterase"
RHEA:17501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polyneuridine-aldehyde esterase"
RHEA:17501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol
RHEA:17501	skos:prefLabel	"polyneuridine-aldehyde esterase"
RHEA:17501	skos:altLabel	"PNAE"
REACT:R-SSC-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Sus scrofa)
REACT:R-CEL-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Caenorhabditis elegans)
REACT:R-DME-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Drosophila melanogaster)
RHEA:68003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1-dichloroethene + AH2 <=> A + chloride + chloroethene + H(+)
RHEA:46486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate
REACT:R-SSC-2018659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Sus scrofa)
GO:0070080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	titin Z domain binding
GO:0070080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Z repeat domain binding
REACT:R-SSC-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Sus scrofa)
REACT:R-HSA-198371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates GSK3 (Homo sapiens)
RHEA:10771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate
REACT:R-RNO-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Rattus norvegicus)
REACT:R-BTA-5661114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Bos taurus)
REACT:R-SSC-193737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Sus scrofa)
REACT:R-BTA-205117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR:NADE promotes caspase2/3 activation (Bos taurus)
REACT:R-RNO-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Rattus norvegicus)
REACT:R-XTR-175987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from AdoMet to PY (Xenopus tropicalis)
REACT:R-HSA-9623240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1 binds PPARGC1A (Homo sapiens)
RHEA:47140	skos:altLabel	"linoleoyl-coenzyme A desaturase"
RHEA:47140	skos:altLabel	"linoleoyl-CoA desaturase"
RHEA:47140	skos:altLabel	"Delta(6)-acyl CoA desaturase"
RHEA:47140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:47140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:47140	skos:altLabel	"fatty acid Delta(6)-desaturase"
RHEA:47140	skos:altLabel	"fatty acid 6-desaturase"
RHEA:47140	skos:altLabel	"Delta(6)-fatty acyl-CoA desaturase"
RHEA:47140	skos:altLabel	"long-chain fatty acid Delta(6)-desaturase"
RHEA:47140	skos:altLabel	"linoleoyl CoA desaturase"
RHEA:47140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA 6-desaturase"
RHEA:47140	skos:altLabel	"linoleic acid desaturase"
RHEA:47140	skos:altLabel	"Delta(6)-desaturase"
RHEA:47140	skos:prefLabel	"acyl-CoA 6-desaturase"
RHEA:47140	skos:altLabel	"linoleate desaturase"
RHEA:26202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammeline + H(+) + H2O => ammelide + NH4(+)
RHEA:19314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)
RHEA:45817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + A => AH2 + pyruvate
REACT:R-RNO-109538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Rattus norvegicus)
REACT:R-SSC-1112708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-Y759-IL6ST (Sus scrofa)
REACT:R-MMU-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Mus musculus)
REACT:R-CEL-429441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK activation by SRC (Caenorhabditis elegans)
REACT:R-XTR-2161660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGE2 by PTGES (Xenopus tropicalis)
GO:0008452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA ligase activity
REACT:R-MMU-5651773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds POLB at long-patch BER site (Mus musculus)
REACT:R-SSC-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Sus scrofa)
RHEA:32474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] <=> (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate => [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)
RHEA:57663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Danio rerio)
REACT:R-SSC-5683930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WICH phosphorylates H2AFX on Y142 (Sus scrofa)
RHEA:46168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + pentanoate = AMP + diphosphate + pentanoyl-CoA
REACT:R-GGA-202365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)
REACT:R-HSA-3323013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
REACT:R-RNO-216050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Rattus norvegicus)
RHEA:24868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 <=> 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate
REACT:R-DME-376122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM/DSCAML1 homodimerization (Drosophila melanogaster)
RHEA:13817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + H2O + phylloquinone = 2,3-epoxyphylloquinone + [protein]-dithiol
RHEA:13817	skos:altLabel	"phylloquinone epoxide reductase"
RHEA:13817	skos:altLabel	"vitamin K1 epoxide reductase"
RHEA:13817	skos:prefLabel	"vitamin-K-epoxide reductase (warfarin-sensitive)"
RHEA:13817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vitamin-K-epoxide reductase (warfarin-sensitive)"
RHEA:13817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + phylloquinol = [protein]-dithiol + phylloquinone
REACT:R-XTR-77254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Xenopus tropicalis)
GO:0001862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	collectin binding
EC:3.4.24.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"procollagen C-endopeptidase"
EC:3.4.24.19	skos:prefLabel	"procollagen C-endopeptidase"
REACT:R-DRE-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Danio rerio)
RHEA:27583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxymethylglutarate => 2-methyleneglutarate + H2O
REACT:R-GGA-1234167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of HIF:CBP:p300 complex at promoters (Gallus gallus)
REACT:R-RNO-6781814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 deubiquitinates RNF123 (Rattus norvegicus)
REACT:R-MMU-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Mus musculus)
RHEA:55747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-DDI-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Dictyostelium discoideum)
REACT:R-RNO-264458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of COP1 (Rattus norvegicus)
RHEA:55445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:21152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline
RHEA:21152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyproline epimerase"
RHEA:21152	skos:altLabel	"hydroxyproline epimerase"
RHEA:21152	skos:altLabel	"hydroxyproline 2-epimerase"
RHEA:21152	skos:prefLabel	"4-hydroxyproline epimerase"
GO:0097383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIDP + H2O = dIMP + H(+) + phosphate
GO:0097383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIDP phosphatase activity
GO:0097383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses dIDP to dIMP (Homo sapiens)
GO:0097383	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyinosine-diphosphatase activity
REACT:R-DRE-5672972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated RAF complex (Danio rerio)
RHEA:22183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-norreticuline + S-adenosyl-L-methionine <=> (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine
RHEA:11713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:51593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene => benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CEL-392835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 sequesters Raf1 to inhibit ERK cascade (Caenorhabditis elegans)
RHEA:72591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)
REACT:R-DRE-163096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Telomerase RNP to the Telomeric Chromosome End (Danio rerio)
REACT:R-DRE-5654573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds SHC1 (Danio rerio)
REACT:R-DDI-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Dictyostelium discoideum)
REACT:R-CEL-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Caenorhabditis elegans)
REACT:R-GGA-4085029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU2 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)
REACT:R-RNO-209891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine is oxidised to noradrenaline (Rattus norvegicus)
GO:0052841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)
GO:0052841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol bisdiphosphate tetrakisphosphate diphosphatase activity
GO:0052841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)
RHEA:32179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-dihydrodipicolinate + NAD(+) = dipicolinate + H(+) + NADH
RHEA:30100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate
RHEA:12546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate => 2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine
REACT:R-HSA-443439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-Src binds Raf1 (Homo sapiens)
REACT:R-SSC-201821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Sus scrofa)
REACT:R-BTA-159101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Bos taurus)
RHEA:61536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-5218642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Mus musculus)
REACT:R-HSA-444202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR1 binds free fatty acids (Homo sapiens)
REACT:R-BTA-8934735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 arginine-methylates RUNX1 (Bos taurus)
REACT:R-SPO-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Schizosaccharomyces pombe)
REACT:R-GGA-3928595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ARP2/3 and G-actin (Gallus gallus)
RHEA:41698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate => 1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O
REACT:R-SSC-5668467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTNFR2 binds TNFA trimer:TNFR2 (Sus scrofa)
REACT:R-HSA-6805573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I/type II heterodimers form tetramers (Homo sapiens)
RHEA:17154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-D-glucose => CDP-4-dehydro-6-deoxy-D-glucose + H2O
RHEA:23120	skos:prefLabel	"ABC-type dipeptide transporter"
RHEA:23120	skos:altLabel	"dipeptide ABC transporter"
RHEA:23120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type dipeptide transporter"
RHEA:23120	skos:altLabel	"dipeptide transporting ATPase"
RHEA:23120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dipeptide(out) + ATP + H2O = a dipeptide(in) + ADP + H(+) + phosphate
REACT:R-RNO-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Rattus norvegicus)
REACT:R-RNO-8936214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCY2C trimer binds GUCA2A,B (Rattus norvegicus)
REACT:R-SSC-3000120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLIF binds RCbl (Sus scrofa)
REACT:R-CEL-5666088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP recruits DAIPH2-3 to endosomes (Caenorhabditis elegans)
REACT:R-XTR-9645535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 phosphorylates TIFA (Xenopus tropicalis)
RHEA:34198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 <=> 2 aureusidin 6-O-beta-glucoside + 2 H2O
RHEA:56285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) => a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH
GO:1902248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphoribose 1-diphosphate binding
GO:1902248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding
GO:1902248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosylpyrophosphate binding
RHEA:44883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]
RHEA:62364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-N(5)-peroxide + thymine = (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)
REACT:R-DDI-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Dictyostelium discoideum)
REACT:R-CEL-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Caenorhabditis elegans)
RHEA:19170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine => NH4(+) + pyruvate
REACT:R-SSC-2161282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastic fibres bind associated proteins (Sus scrofa)
RHEA:46144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:3.6.5.n1	skos:prefLabel	"elongation factor 4"
EC:3.6.5.n1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"elongation factor 4"
REACT:R-HSA-9622386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEF1 binds the promoter of the CEBPA gene (Homo sapiens)
REACT:R-MMU-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Mus musculus)
REACT:R-GGA-351429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of 53BP1 with gamma H2AX at double strand break (Gallus gallus)
RHEA:11487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + 2 Fe(III)-[cytochrome c](out) <=> a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
RHEA:54394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O
GO:0008411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutyrate CoA-transferase activity
RHEA:36577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoyl-CoA + sphinganine
RHEA:59004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + H2O + O2 = dodecanoate + H(+) + H2O2
REACT:R-HSA-9657775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ANGPTL3 regulated by NR1H2 or NR1H3 (Homo sapiens)
RHEA:25688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-tRNA(Cys) + phosphate => H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys)
REACT:R-MMU-430311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rsu-1 interacts with Pinch1 (Mus musculus)
RHEA:61568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine
RHEA:70521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-synephrine + H(+) + S-adenosyl-L-homocysteine => (R)-octopamine + S-adenosyl-L-methionine
RHEA:60991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hex-2-en-1-ol + NAD(+) <=> (E)-hex-2-enal + H(+) + NADH
RHEA:45107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-demethylmitomycin A + S-adenosyl-L-methionine <=> mitomycin A + S-adenosyl-L-homocysteine
RHEA:41118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine
RHEA:22092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] = 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:22092	skos:prefLabel	"phycoerythrobilin:ferredoxin oxidoreductase"
RHEA:22092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phycoerythrobilin:ferredoxin oxidoreductase"
REACT:R-SCE-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Saccharomyces cerevisiae)
REACT:R-DME-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
REACT:R-DME-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Drosophila melanogaster)
GO:0005267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium channel activity
RHEA:22115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)
REACT:R-BTA-173488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
RHEA:47899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-D-quinovose + NAD(+) <=> 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH
RHEA:40084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-2731081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrin alphaVBeta5 (Homo sapiens)
REACT:R-CEL-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Caenorhabditis elegans)
REACT:R-CEL-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Caenorhabditis elegans)
RHEA:39285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid(in) => a long-chain fatty acid(out)
RHEA:63625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-AMP + holo-[ACP] => AMP + H(+) + hexadecanoyl-[ACP]
RHEA:40783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + H2O = CoA + docosanoate + H(+)
REACT:R-RNO-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Rattus norvegicus)
REACT:R-HSA-8951500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CANX from nonameric complex (Homo sapiens)
RHEA:13427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine nucleobase + D-ribose 5-phosphate => a pyrimidine ribonucleoside 5'-phosphate + H2O
RHEA:61218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate
REACT:R-SSC-352174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Sus scrofa)
REACT:R-SCE-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Saccharomyces cerevisiae)
REACT:R-SSC-3371518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 binds to HSF1 (Sus scrofa)
RHEA:39286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid(out) <=> a long-chain fatty acid(in)
REACT:R-GGA-74742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 (Gallus gallus)
RHEA:39757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:32161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + queuosine(34) in tRNA => AH2 + epoxyqueuosine(34) in tRNA
RHEA:15838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + methylamine => N-methyl-L-glutamate + NH4(+)
REACT:R-DDI-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Dictyostelium discoideum)
RHEA:28965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-proline(in) => H(+)(out) + L-proline(out)
REACT:R-GGA-8862733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR2, CCR3 bind CCL13 (Gallus gallus)
REACT:R-BTA-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Bos taurus)
REACT:R-BTA-9638097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Bos taurus)
REACT:R-CFA-5649726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Canis familiaris)
RHEA:64925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + 2 H2O => dAMP + 2 H(+) + 2 phosphate
REACT:R-GGA-2132210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b fragment binds to the target cell surface (Gallus gallus)
REACT:R-XTR-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Xenopus tropicalis)
REACT:R-MMU-109530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Mus musculus)
REACT:R-DRE-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Danio rerio)
REACT:R-RNO-444620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide S receptor binds neuropeptide S (Rattus norvegicus)
RHEA:67156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)
GO:0001874	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(1->3)-beta-D-glucan receptor activity
GO:0001874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1,3)-beta-D-glucan receptor activity
GO:0001874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-beta-D-glucan receptor activity
GO:0001874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1->3)-beta-D-glucan immune receptor activity
GO:0001874	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	zymosan receptor activity
GO:0001874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,3-D-glucan receptor activity
REACT:R-MMU-2395364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP4 binds TGF-Beta-1 (Mus musculus)
REACT:R-RNO-203716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1 complex binds to Nostrin (Rattus norvegicus)
RHEA:37267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-aspartate = L-alanine + L-aspartate
RHEA:71085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(in) + 2 Na(+)(in) => estrone 3-sulfate(out) + 2 Na(+)(out)
REACT:R-XTR-5660666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBP and p300 binds NF-kB complex (Xenopus tropicalis)
EC:2.3.1.241	skos:altLabel	"Kdo2-lipid IVA acyltransferase"
EC:2.3.1.241	skos:altLabel	"alpha-Kdo-(2->4)-alpha-(2->6)-lipid IVA lauroyltransferase"
EC:2.3.1.241	skos:prefLabel	"Kdo2-lipid IVA lauroyltransferase"
EC:2.3.1.241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Kdo2-lipid IVA lauroyltransferase"
EC:2.3.1.241	skos:altLabel	"(Kdo)2-lipid IVA lauroyltransferase"
RHEA:13678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate => D-xylulose 5-phosphate
GO:0102262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-dihydrouridine16 synthase activity
RHEA:18399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-glutamyl-tRNA(Glx) => ATP + L-glutamate + tRNA(Glx)
RHEA:68479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroperoxy fatty acid + H(+) <=> a fatty aldehyde + CO2 + H2O
GO:0102429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein-3-O-glucoside 1,6-glucosyltransferase activity
REACT:R-DDI-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)
REACT:R-BTA-9603987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Bos taurus)
REACT:R-BTA-9650858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Meglitinides bind ABCC8 (Bos taurus)
RHEA:17990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[protein] => ADP + H(+) + O-phospho-L-seryl-[protein]
RHEA:59455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + NADP(+) <=> a long-chain fatty aldehyde + H(+) + NADPH
RHEA:59667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellopentaose + O2 <=> D-cellopentaono-1,5-lactone + H2O2
REACT:R-CEL-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Caenorhabditis elegans)
RHEA:71339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-tyrosine(out) + 2 Na(+)(out) = chloride(in) + L-tyrosine(in) + 2 Na(+)(in)
REACT:R-DRE-77342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Danio rerio)
REACT:R-SSC-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Sus scrofa)
REACT:R-DRE-1606789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses DS (Danio rerio)
RHEA:31471	skos:altLabel	"UGT75L6"
RHEA:31471	skos:altLabel	"crocetin GTase"
RHEA:31471	skos:prefLabel	"crocetin glucosyltransferase"
RHEA:31471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP
RHEA:31471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"crocetin glucosyltransferase"
GO:0016833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxoacid lyase activity
GO:0016833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxo-acid lyase activity
GO:0016833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxo-acid-lyase activity
RHEA:57796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite
RHEA:63280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-BTA-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Bos taurus)
RHEA:52096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + octadecanoate
RHEA:66627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
GO:0019903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphatase binding
REACT:R-HSA-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Homo sapiens)
REACT:R-BTA-9012000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Bos taurus)
REACT:R-BTA-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Bos taurus)
GO:0047670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anhydrotetracycline oxygenase activity
GO:0047670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATC oxygenase activity
GO:0047670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)
GO:0047670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anhydrotetracycline monooxygenase activity
RHEA:67953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5682607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Gallus gallus)
RHEA:14717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate
RHEA:14717	skos:altLabel	"phospho-2-keto-3-deoxyheptonic aldolase"
RHEA:14717	skos:altLabel	"DS-Co"
RHEA:14717	skos:altLabel	"DHAP synthase"
RHEA:14717	skos:altLabel	"DAHP synthase"
RHEA:14717	skos:altLabel	"phospho-2-dehydro-3-deoxyheptonate aldolase"
RHEA:14717	skos:altLabel	"3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase"
RHEA:14717	skos:altLabel	"phospho-2-oxo-3-deoxyheptonate aldolase"
RHEA:14717	skos:altLabel	"3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase"
RHEA:14717	skos:altLabel	"DAH7-P synthase"
RHEA:14717	skos:altLabel	"2-dehydro-3-deoxy-phosphoheptonate aldolase"
RHEA:14717	skos:altLabel	"D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating)"
RHEA:14717	skos:altLabel	"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating)"
RHEA:14717	skos:altLabel	"deoxy-D-arabino-heptulosonate-7-phosphate synthetase"
RHEA:14717	skos:altLabel	"phospho-2-keto-3-deoxyheptanoate aldolase"
RHEA:14717	skos:altLabel	"3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase"
RHEA:14717	skos:altLabel	"2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase"
RHEA:14717	skos:altLabel	"KDPH synthase"
RHEA:14717	skos:altLabel	"KDPH synthetase"
RHEA:14717	skos:altLabel	"7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating)"
RHEA:14717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-7-phosphoheptulonate synthase"
RHEA:14717	skos:altLabel	"D-erythrose-4-phosphate-lyase"
RHEA:14717	skos:altLabel	"phospho-2-keto-3-deoxyheptonate aldolase"
RHEA:14717	skos:altLabel	"DS-Mn"
RHEA:14717	skos:prefLabel	"3-deoxy-7-phosphoheptulonate synthase"
EC:2.7.11.8	skos:prefLabel	"Fas-activated serine/threonine kinase"
EC:2.7.11.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Fas-activated serine/threonine kinase"
EC:2.7.11.8	skos:altLabel	"FASTK"
EC:2.7.11.8	skos:altLabel	"FAST"
REACT:R-HSA-8875568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 activates RAP1 (Homo sapiens)
REACT:R-HSA-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Homo sapiens)
RHEA:66023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O
REACT:R-CFA-2028555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Canis familiaris)
REACT:R-HSA-9749583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Homo sapiens)
REACT:R-BTA-192434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of diacylglycerols by extracellular PTL:colipase (Bos taurus)
GO:0018800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HpaG-2
GO:0018800	skos:prefLabel	"5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase"
GO:0018800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (4Z)-2-oxohept-4-enedioate + CO2
GO:0018800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity
GO:0018800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HpaG2
GO:0018800	skos:altLabel	"5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase"
GO:0018800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPET decarboxylase activity
GO:0018800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity
GO:0018800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity
GO:0018800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)
GO:0018800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase"
GO:0018800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity
REACT:R-CEL-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Caenorhabditis elegans)
REACT:R-RNO-917744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA loaded synaptic vesicle Docking and Priming (Rattus norvegicus)
RHEA:71705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurocholate(in) => taurocholate(out)
REACT:R-BTA-77338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Bos taurus)
REACT:R-CFA-8864343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD1 binds TFAP2 homo- and heterodimers (Canis familiaris)
REACT:R-SSC-400037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi,Go Heterotrimeric G-protein complex dissociates (Sus scrofa)
REACT:R-MMU-8875490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind ubiquitinated MET (Mus musculus)
REACT:R-CFA-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Canis familiaris)
REACT:R-DRE-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Danio rerio)
RHEA:51178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine
RHEA:60903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in RNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-5617179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates TNNI3 (Canis familiaris)
REACT:R-MMU-112265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Mus musculus)
REACT:R-RNO-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Rattus norvegicus)
RHEA:48010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxybenzoyl-CoA + H2O + NAD(+) => 2-hydroxybenzoyl-CoA + H(+) + NADH + O2
REACT:R-CFA-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)
RHEA:34544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP
GO:0033858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine kinase activity
GO:0033858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GK2
GO:0033858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity
GO:0033858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity
GO:0033858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GalNAc kinase activity
GO:0033858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GALK2
REACT:R-RNO-73912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Rattus norvegicus)
REACT:R-HSA-2161282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastic fibres bind associated proteins (Homo sapiens)
RHEA:12715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+) => a nucleoside 5'-phosphate + ATP
REACT:R-HSA-751040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates G alpha (z) (Homo sapiens)
REACT:R-HSA-2520883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated condensin I promotes condensation of prometaphase chromosomes (Homo sapiens)
REACT:R-SPO-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Schizosaccharomyces pombe)
RHEA:58042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+) => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O
RHEA:58073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4,5-didehydrojasmonate + H(+) + NADPH => a jasmonate + NADP(+)
REACT:R-XTR-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Xenopus tropicalis)
RHEA:19862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16alpha-hydroxysteroid + NAD(+) => a 16-oxosteroid + H(+) + NADH
REACT:R-CEL-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Caenorhabditis elegans)
REACT:R-GGA-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Gallus gallus)
REACT:R-RNO-3323013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
REACT:R-MMU-2872497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-2 transports cytosolic urate to extracellular region (Mus musculus)
REACT:R-CFA-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)
RHEA:29044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)
RHEA:12610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mercaptopurine + S-adenosyl-L-methionine => 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Sus scrofa)
REACT:R-HSA-1253325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds TAB2:NCOR1 complex (Homo sapiens)
REACT:R-SSC-2168038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XV restin release (Sus scrofa)
REACT:R-BTA-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Bos taurus)
REACT:R-CFA-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Canis familiaris)
REACT:R-SPO-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Schizosaccharomyces pombe)
REACT:R-CFA-5252041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Canis familiaris)
REACT:R-MMU-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Mus musculus)
REACT:R-SSC-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Sus scrofa)
REACT:R-XTR-4420153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds PLCG1 (Xenopus tropicalis)
REACT:R-HSA-9691566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 binds nicorandil (Homo sapiens)
GO:0097008	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNMT synthase activity
GO:0097008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-4,8-dimethylnona-1,3,7-triene synthase activity
GO:0097008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity
REACT:R-SSC-2161791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Sus scrofa)
REACT:R-DRE-3222093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 binds TP53 and EP300 (Danio rerio)
RHEA:16443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-[protein] + NH4(+) => H2O + L-glutaminyl-[protein]
REACT:R-SSC-5662986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds copper (Sus scrofa)
RHEA:34985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate(out) => sulfate(in)
REACT:R-SSC-8934465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds PTPN12 (Sus scrofa)
RHEA:46048	skos:prefLabel	"phosphogalactosamine mutase"
RHEA:46048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphogalactosamine mutase"
RHEA:46048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactosamine 6-phosphate = alpha-D-galactosamine 1-phosphate
REACT:R-MMU-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Mus musculus)
GO:0030337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase processivity factor activity
GO:0030337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	processivity clamp
GO:0030337	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sliding clamp
RHEA:60997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-leucine + O2 => 4-methyl-2-oxopentanoate + H2O2 + NH4(+)
REACT:R-HSA-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Homo sapiens)
REACT:R-XTR-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Xenopus tropicalis)
RHEA:43321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
RHEA:28097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl diphosphate + H2O <=> di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate
RHEA:46369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-XTR-176175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Stalling of DNA replication fork and RPA binding (Xenopus tropicalis)
RHEA:45438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate => H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:34287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone
REACT:R-SCE-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)
REACT:R-HSA-2671747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated LEPR Binds SHP2 (PTPN11) (Homo sapiens)
REACT:R-BTA-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Bos taurus)
RHEA:47208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:50894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + thiosulfate => a menaquinone + 2 H(+) + hydrogen sulfide + sulfite
REACT:R-CEL-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Caenorhabditis elegans)
REACT:R-BTA-9626880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Bos taurus)
REACT:R-DRE-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Danio rerio)
REACT:R-HSA-5676595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAFs bind RANK:RANKL (Homo sapiens)
REACT:R-RNO-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Rattus norvegicus)
RHEA:36191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine
GO:0047266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(ribitol-phosphate) beta-glucosyltransferase activity
GO:0047266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity
GO:0047266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-glucose:polyribitol phosphate glucosyl transferase activity
GO:0047266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity
GO:0047266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-glucose polyribitol phosphate glucosyl transferase activity
GO:0047266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity
GO:0047266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity
REACT:R-BTA-1889955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT dimers transfer GlcA to tetrasaccharide linker (Bos taurus)
REACT:R-HSA-166726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MASPs (Homo sapiens)
RHEA:63815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(8)-citryl-spermidine + spermidine <=> AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)
RHEA:56646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pseudouridine in mRNA => a uridine in mRNA
RHEA:39053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + cholesterol(out) + H(+) + phosphate => ATP + cholesterol(in) + H2O
RHEA:63939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a ubiquinone + protoporphyrinogen IX <=> 3 a ubiquinol + protoporphyrin IX
RHEA:67636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-2'-deoxyadenylo-succinate = dZMP + fumarate
RHEA:42503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH
REACT:R-CFA-186798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binds to PDGF-beta receptors only (Canis familiaris)
RHEA:72571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) = dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)
RHEA:39400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O
RHEA:32527	skos:prefLabel	"N,N'-diacetylchitobiose phosphorylase"
RHEA:32527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N,N'-diacetylchitobiose phosphorylase"
RHEA:32527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose + phosphate = N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine
REACT:R-DRE-688137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 is K63 polyubiquitinated (Danio rerio)
RHEA:58519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0086078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling
REACT:R-HSA-379982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate (Homo sapiens)
RHEA:58825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-5229194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Depolymerization of lamin filaments after PKC-mediated phosphorylation (Bos taurus)
REACT:R-SCE-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)
REACT:R-CFA-6797961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHDH oxidises Cho to BETALD (Canis familiaris)
REACT:R-HSA-8853313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2 fusions autophosphorylate (Homo sapiens)
REACT:R-SSC-9733292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind pramlintide (Sus scrofa)
REACT:R-HSA-8944078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1 binds the PTEN gene promoter (Homo sapiens)
RHEA:70784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-aspartate(in) + L-glutamate(out) => H(+)(in) + L-aspartate(out) + L-glutamate(in)
RHEA:63471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-octaprenol + ATP <=> ADP + all-trans-octaprenyl phosphate + H(+)
REACT:R-HSA-8848392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL18BP binds IL18 (Homo sapiens)
RHEA:23189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADH
REACT:R-GGA-372359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] (Gallus gallus)
RHEA:60990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hex-2-enal + H(+) + NADH => (E)-hex-2-en-1-ol + NAD(+)
REACT:R-DRE-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Danio rerio)
REACT:R-DME-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Drosophila melanogaster)
RHEA:15037	skos:prefLabel	"putrescine N-methyltransferase"
RHEA:15037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + S-adenosyl-L-methionine = H(+) + N-methylputrescine + S-adenosyl-L-homocysteine
RHEA:15037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"putrescine N-methyltransferase"
REACT:R-BTA-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Bos taurus)
RHEA:28218	skos:altLabel	"MPO"
RHEA:28218	skos:prefLabel	"myeloperoxidase"
RHEA:28218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"myeloperoxidase"
RHEA:28218	skos:altLabel	"verdoperoxidase"
RHEA:28218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + H(+) + H2O2 = H2O + hypochlorous acid
REACT:R-CFA-166214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion flip-flops to the opposite surface (Canis familiaris)
REACT:R-CFA-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Canis familiaris)
RHEA:60863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:49507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphinomethylmalate <=> phosphinomethylisomalate
REACT:R-XTR-8959462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Xenopus tropicalis)
RHEA:43866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in)
REACT:R-HSA-159773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein S to protein S (Homo sapiens)
RHEA:36774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
REACT:R-RNO-8938887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML binds RUNX1 (Rattus norvegicus)
REACT:R-DME-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Drosophila melanogaster)
REACT:R-RNO-210282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GPVI and FceRI gamma (Rattus norvegicus)
RHEA:45794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein S23]-L-proline + O2
REACT:R-DME-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Drosophila melanogaster)
RHEA:16362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate
REACT:R-SPO-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Schizosaccharomyces pombe)
REACT:R-DDI-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Dictyostelium discoideum)
REACT:R-DRE-2187325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 ADP-ribosylates SMAD3 and SMAD4 (Danio rerio)
RHEA:30939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dIDP = ADP + dITP
REACT:R-MMU-110354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of OGG1 glycosylase by APEX1 at the AP site (Mus musculus)
RHEA:22924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H(+) + H2O = dUMP + NH4(+)
RHEA:22924	skos:altLabel	"deoxycytidylate deaminase"
RHEA:22924	skos:prefLabel	"dCMP deaminase"
RHEA:22924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dCMP deaminase"
RHEA:28224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate 6-phosphate + ADP + H(+) => 3-dehydro-L-gulonate + ATP
REACT:R-HSA-982768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GH:GHR:JAK2 complex undergoes a conformational change (Homo sapiens)
RHEA:12098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylamine + formate => H2O + N-benzylformamide
RHEA:52684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pyridoxine = H(+) + NADH + pyridoxal
REACT:R-HSA-5654709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-DRE-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Danio rerio)
RHEA:31710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al
REACT:R-RNO-1604350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14:TIMP2 binds proMMP2 (Rattus norvegicus)
RHEA:45197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] => 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)
REACT:R-BTA-5651657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Bos taurus)
REACT:R-GGA-8938913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF1 (Gallus gallus)
REACT:R-GGA-9735946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET small tyrosine kinase inhibitors bind MET (Gallus gallus)
RHEA:39484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)
REACT:R-HSA-1022129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)
REACT:R-DDI-5205861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Dictyostelium discoideum)
REACT:R-GGA-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Gallus gallus)
REACT:R-XTR-4420128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates SHB (Xenopus tropicalis)
RHEA:42454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate => 4-(2-aminophenyl)-2,4-dioxobutanoate
RHEA:15034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pyridoxine => H2O2 + pyridoxal
REACT:R-GGA-9023619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Gallus gallus)
RHEA:40620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tridodecanoylglycerol => 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)
RHEA:29122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + nitrate <=> a ubiquinone + H2O + nitrite
REACT:R-GGA-353058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose 6-phosphate + H2O => glucose + phosphate (Gallus gallus)
RHEA:21361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-nicotinamide D-ribonucleotide + H(+) => diphosphate + NAD(+)
RHEA:22731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + phosphate
REACT:R-CFA-5676599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF trimer binds BAFFR (Canis familiaris)
REACT:R-DRE-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Danio rerio)
RHEA:68515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> alpha-acoradiene + diphosphate
EC:5.4.99.-	skos:prefLabel	"Transferring other groups"
EC:5.4.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring other groups"
REACT:R-XTR-4570485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO3 (Xenopus tropicalis)
RHEA:13222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + NAD(+) => H(+) + mevaldate + NADH
RHEA:45532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine
RHEA:14870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative
GO:0106240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	labd-13Z-ene-9,15,16-triol synthase activity
GO:0106240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-3214912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate MeK5-histone H3 (Canis familiaris)
REACT:R-SSC-177931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Sus scrofa)
REACT:R-HSA-9625482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated EGFR (Homo sapiens)
REACT:R-BTA-211924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4B1 12-hydroxylates ARA (Bos taurus)
REACT:R-HSA-5607721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NIK (Homo sapiens)
RHEA:62674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine => a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine
REACT:R-SSC-5672843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1S1 (PRAS40) binds mTORC1 (Sus scrofa)
RHEA:50160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine
REACT:R-SSC-1566962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by elastin-degrading extracellular proteinases (Sus scrofa)
GO:0102439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5'-trimethylmyricetin 7-O-methyltransferase activity
RHEA:56274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(II)-[cytochrome cL] + formate + 5 H(+) => 4 Fe(III)-[cytochrome cL] + H2O + methanol
REACT:R-RNO-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Rattus norvegicus)
RHEA:23626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in tRNA + H(+) + NADPH => a 5,6-dihydrouridine in tRNA + NADP(+)
REACT:R-HSA-2467716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds Alpha-dystroglycan (Homo sapiens)
REACT:R-MMU-2428922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Mus musculus)
RHEA:53132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-Delta(4)-steroid = a 3-oxo-Delta(1,4)-steroid + AH2
RHEA:58264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside
REACT:R-CEL-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Caenorhabditis elegans)
REACT:R-CFA-9698408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates active FLT3 (Canis familiaris)
RHEA:17454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-beta-D-ribosylamine + ATP + glycine => ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate
RHEA:45587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O
RHEA:16562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + squalene => hopan-22-ol
REACT:R-DME-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Drosophila melanogaster)
REACT:R-XTR-2022403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)
RHEA:20865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + phosphate => beta-D-glucose 1-phosphate + D-glucose 6-phosphate
REACT:R-RNO-9009558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds SDC1 (Rattus norvegicus)
REACT:R-MMU-9708859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Mus musculus)
REACT:R-SSC-190326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 (Sus scrofa)
RHEA:50858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2
REACT:R-RNO-5685902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Rattus norvegicus)
RHEA:57739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-3,4-didehydro-13,14-dihydroretinol <=> AH2 + all-trans-3,4-didehydroretinol
REACT:R-GGA-190681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in endoplasmic reticulum membrane (Gallus gallus)
REACT:R-GGA-216988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of PCNA (Gallus gallus)
REACT:R-HSA-9728664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1R agonists (Homo sapiens)
REACT:R-DME-8854981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 in the RET complex is phosphorylated (Drosophila melanogaster)
RHEA:40052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O
REACT:R-SSC-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Sus scrofa)
REACT:R-RNO-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Rattus norvegicus)
RHEA:34403	skos:prefLabel	"carlactone synthase"
RHEA:34403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carlactone synthase"
RHEA:34403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-10'-apo-beta-carotenal + 2 O2 = (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone
REACT:R-HSA-9698043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)
RHEA:67030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate => (glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O
REACT:R-XTR-5635865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 dissociates from ub-PTCH1 (Xenopus tropicalis)
REACT:R-DRE-198611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates IKKalpha (Danio rerio)
GO:0102626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	parthenolide synthase activity
RHEA:69429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite + 3 glutathione + H(+) => arsenic triglutathione + 3 H2O
REACT:R-RNO-4655374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DNMT3B with SUMO1 (Rattus norvegicus)
RHEA:41459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine
RHEA:26384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + NADP(+) <=> H(+) + NADPH + succinate semialdehyde
RHEA:24829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate
RHEA:24829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosylglycinamide formyltransferase 2"
RHEA:24829	skos:altLabel	"GAR transformylase T"
RHEA:24829	skos:altLabel	"5'-phosphoribosylglycinamide transformylase 2"
RHEA:24829	skos:prefLabel	"phosphoribosylglycinamide formyltransferase 2"
RHEA:24829	skos:altLabel	"GART2"
RHEA:24829	skos:altLabel	"glycinamide ribonucleotide transformylase 2"
RHEA:24829	skos:altLabel	"GAR transformylase 2"
RHEA:43256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate
RHEA:25769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CO2 => 3-carboxy-2-oxobutanoate + H(+)
REACT:R-RNO-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Rattus norvegicus)
RHEA:51231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate <=> 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
GO:1901505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate derivative transmembrane transporter activity
GO:1901505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbohydrate derivative transporter activity
RHEA:49894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2
RHEA:24958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate => H2O + N-acetyl-beta-D-muramate 6-phosphate
REACT:R-DRE-446648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Danio rerio)
REACT:R-MMU-69685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TP53 (Mus musculus)
REACT:R-RNO-9705794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 binds SRD5A2 inhibitors (Rattus norvegicus)
REACT:R-HSA-8934690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIFR gene expression (Homo sapiens)
REACT:R-XTR-77283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Xenopus tropicalis)
REACT:R-HSA-9022453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds 5hmC-DNA (Homo sapiens)
REACT:R-CEL-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Caenorhabditis elegans)
REACT:R-GGA-983422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of COPII coated vesicle (Gallus gallus)
REACT:R-DRE-982778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone binds the growth hormone receptor (Danio rerio)
REACT:R-CEL-2129362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin microfibril assembly (Caenorhabditis elegans)
REACT:R-MMU-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Mus musculus)
REACT:R-PFA-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Plasmodium falciparum)
GO:0017178	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphthine:ammonia ligase (ADP-forming)
GO:0017178	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphthamide synthase activity
GO:0017178	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphthamide synthetase activity
GO:0017178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthine-ammonia ligase activity
REACT:R-CEL-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
RHEA:41186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
GO:0070523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0070523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11beta-hydroxysteroid + NAD(+) = an 11-oxosteroid + H(+) + NADH
REACT:R-SCE-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Saccharomyces cerevisiae)
RHEA:14874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-ethanol + NAD(+) => H(+) + indole-3-acetaldehyde + NADH
REACT:R-DRE-5682893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12:ATG7:CysO572-ATG7 binds ATG10 (Danio rerio)
RHEA:16659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose + hypoxanthine => H2O + inosine
REACT:R-HSA-5689973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10,USP24,USP42 deubiquitinate TP53 (Homo sapiens)
REACT:R-CFA-158893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Canis familiaris)
REACT:R-RNO-5226964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKH transports PPi from cytosol to extracellular region (Rattus norvegicus)
RHEA:19777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + L-pipecolate = AH2 + H(+) + L-1-piperideine-6-carboxylate
RHEA:19777	skos:prefLabel	"L-pipecolate dehydrogenase"
RHEA:19777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-pipecolate dehydrogenase"
REACT:R-CFA-975119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Canis familiaris)
REACT:R-DDI-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)
REACT:R-RNO-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Rattus norvegicus)
RHEA:28261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate <=> cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP
REACT:R-SSC-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Sus scrofa)
RHEA:58662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine
REACT:R-HSA-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Homo sapiens)
REACT:R-HSA-1655849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) (Homo sapiens)
REACT:R-MMU-265426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Tenascin (Mus musculus)
REACT:R-PFA-3341296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX7,8 catalyze peroxidation of P4HB (PDI) (Plasmodium falciparum)
REACT:R-HSA-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Homo sapiens)
RHEA:55109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxononanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxynonanoyl-[ACP] + NADP(+)
GO:0016885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase activity, forming carbon-carbon bonds
GO:0016885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming carbon-carbon bonds"
GO:0016885	skos:prefLabel	"Forming carbon-carbon bonds"
REACT:R-DDI-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Dictyostelium discoideum)
REACT:R-DRE-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Danio rerio)
REACT:R-MMU-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Mus musculus)
REACT:R-XTR-606349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mis18 complex binds the centromere (Xenopus tropicalis)
RHEA:10136	skos:altLabel	"tartronate semialdehyde carboxylase"
RHEA:10136	skos:prefLabel	"tartronate-semialdehyde synthase"
RHEA:10136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2
RHEA:10136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tartronate-semialdehyde synthase"
RHEA:10136	skos:altLabel	"glyoxylate carboligase"
RHEA:47948	skos:prefLabel	"thiamine phosphate phosphatase"
RHEA:47948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiamine phosphate phosphatase"
RHEA:47948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine phosphate = phosphate + thiamine
RHEA:52226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + biliverdin delta + CO + Fe(2+) + 3 H2O => 3 AH2 + 3 H(+) + heme b + 3 O2
REACT:R-XTR-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Xenopus tropicalis)
REACT:R-GGA-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Gallus gallus)
REACT:R-GGA-266299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds membrane-associated free cholesterol and phospholipids (Gallus gallus)
RHEA:37882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl aklanonate <=> aklaviketone
RHEA:16075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dialkyl ketone + L-alanine => 2,2-dialkylglycine + H(+) + pyruvate
REACT:R-CFA-77304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Canis familiaris)
RHEA:21250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + RNA(n+1) => a ribonucleoside 5'-triphosphate + RNA(n)
RHEA:38710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol
REACT:R-BTA-5675470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC2/3 (cIAP1/2) is autoubiquitinated (Bos taurus)
REACT:R-CEL-3343700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)
RHEA:55370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine => (R)-carnitine + H(+) + NADPH + O2
RHEA:22370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate => L-ribulose 5-phosphate
RHEA:61357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + methotrexate(in) => ADP + H(+) + methotrexate(out) + phosphate
REACT:R-MMU-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Mus musculus)
REACT:R-GGA-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Gallus gallus)
REACT:R-HSA-9728752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)
RHEA:64106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein] => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein]
REACT:R-MMU-378975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follitropin is a heterodimer (Mus musculus)
RHEA:54686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
RHEA:23088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkylglycerone kinase"
RHEA:23088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-alkylglycerone = 1-O-alkylglycerone 3-phosphate + ADP + H(+)
RHEA:23088	skos:prefLabel	"alkylglycerone kinase"
REACT:R-SSC-5359451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from SAM to NAM to form MNA (Sus scrofa)
EC:1.14.99.56	skos:prefLabel	"lytic cellulose monooxygenase (C4-dehydrogenating)"
EC:1.14.99.56	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lytic cellulose monooxygenase (C4-dehydrogenating)"
GO:0047753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline-sulfate sulfohydrolase activity
GO:0047753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline-sulphatase activity
GO:0047753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline-sulfatase activity
GO:0047580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyproline epimerase activity
GO:0047580	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-hydroxyproline epimerase activity
GO:0047580	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyproline 2-epimerase activity
GO:0047580	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyproline 2-epimerase activity
GO:0047580	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyproline epimerase activity
GO:0009036	skos:prefLabel	"type II site-specific deoxyribonuclease"
GO:0009036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II restriction enzyme activity
GO:0009036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"type II site-specific deoxyribonuclease"
GO:0009036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II site-specific deoxyribonuclease activity
GO:0009036	skos:altLabel	"type II restriction enzyme"
REACT:R-DRE-2161917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15S-HpETE to LXA4/B4 (Danio rerio)
REACT:R-CEL-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)
REACT:R-MMU-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Mus musculus)
REACT:R-SSC-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Sus scrofa)
REACT:R-XTR-9679775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT binds COMT Inhibitors (Xenopus tropicalis)
REACT:R-SSC-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Sus scrofa)
REACT:R-SSC-2046222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Sus scrofa)
REACT:R-HSA-9703895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds CASR agonists (Homo sapiens)
RHEA:43624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomalonate semialdehyde + H(+) = aminoacetaldehyde + CO2
REACT:R-DRE-194023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2,HSD11B1 dimer oxidise CORT to COR (Danio rerio)
RHEA:45865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA
EC:3.1.26.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease E"
EC:3.1.26.12	skos:altLabel	"endoribonuclease E"
EC:3.1.26.12	skos:altLabel	"RNase E"
EC:3.1.26.12	skos:prefLabel	"ribonuclease E"
REACT:R-HSA-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Homo sapiens)
RHEA:42686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide => gamma-L-glutamyl-hercynylcysteine S-oxide + H2O
RHEA:71995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + preaspterpenacid acid I
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iduronate-2-sulfatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-iduronate-2-sulfate 2-sulfohydrolase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-sulfo-L-iduronate 2-sulfatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iduronate-2-sulfate sulfatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinsulfatase
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-iduronosulfatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfoiduronate sulfohydrolase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-idurono sulfate sulfatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfo-L-iduronate sulfatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iduronate sulfatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iduronate-2-sulphatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-iduronate 2-sulfate sulfatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iduronate sulfate sulfatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	idurono-2-sulfatase activity
GO:0004423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iduronide-2-sulfate sulfatase activity
REACT:R-HSA-9686922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 binds activated RIPK1:RIPK3 (Homo sapiens)
REACT:R-CEL-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Caenorhabditis elegans)
REACT:R-XTR-9613570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Xenopus tropicalis)
RHEA:55971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-kolavelool + S-adenosyl-L-methionine <=> (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Rattus norvegicus)
REACT:R-GGA-5654404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds SHC1 (Gallus gallus)
REACT:R-CFA-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)
RHEA:34076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl phosphate + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + phosphate
RHEA:33819	skos:prefLabel	"3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase"
RHEA:33819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase"
RHEA:33819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate = 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate
REACT:R-DME-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Drosophila melanogaster)
RHEA:40449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA => (2R)-pristanoyl-CoA
RHEA:46321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-chol-5-ene-24-oyl-CoA + A => 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2
RHEA:65136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:30466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate
RHEA:72800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-homoarginine(in) => L-arginine(in) + L-homoarginine(out)
REACT:R-DDI-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Dictyostelium discoideum)
GO:0035757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine (C-C motif) ligand 19 binding
GO:0035757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCL19 binding
REACT:R-MMU-8849350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Mus musculus)
REACT:R-CFA-194678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 demethylates LNSOL (Canis familiaris)
RHEA:70788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-citrulline(in) + L-ornithine(out) => H(+)(out) + L-citrulline(out) + L-ornithine(in)
RHEA:13196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
RHEA:22990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + CO2 + NADPH => 3-oxopropanoate + CoA + NADP(+)
REACT:R-DRE-2018659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Danio rerio)
RHEA:40780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminopentanenitrile + H(+) + 2 H2O => L-2-aminopentanoate + NH4(+)
REACT:R-RNO-8952044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
REACT:R-BTA-6788571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 bind IL13:IL13R type II (Bos taurus)
RHEA:57910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP => ATP + L-glutamyl-tRNA(Gln)
REACT:R-HSA-6785087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA (Homo sapiens)
REACT:R-DRE-2530445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD59 inhibits MAC formation (Danio rerio)
RHEA:60852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine
RHEA:18254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NADP(+) => CO2 + NADPH + pyruvate
REACT:R-XTR-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Xenopus tropicalis)
RHEA:23009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + H2O => D-glucose + D-glucose 6-phosphate
RHEA:43355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)
RHEA:37711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
RHEA:24116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-linalool synthase"
RHEA:24116	skos:altLabel	"LIS"
RHEA:24116	skos:altLabel	"3S-linalool synthase"
RHEA:24116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = (S)-linalool + diphosphate
RHEA:24116	skos:prefLabel	"S-linalool synthase"
REACT:R-XTR-4420206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SRC-1 (Xenopus tropicalis)
RHEA:48277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine
RHEA:55270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + alpha-D-glucose 1-phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate
REACT:R-HSA-379844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic isomerase activity
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic acid mutase activity
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylaspartate mutase activity
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	b-methylaspartate-glutamate mutase activity
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic mutase activity
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate isomerase activity
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylaspartic acid mutase activity
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-methylaspartate-glutamate mutase activity
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate mutase activity
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threo-3-methylaspartate carboxy-aminomethylmutase activity
GO:0050097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic acid isomerase activity
REACT:R-DRE-5218811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO binds CRK (Danio rerio)
RHEA:19894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP
REACT:R-BTA-5683384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UIMC1 and FAM175A bind DNA DSBs (Bos taurus)
REACT:R-MMU-352174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Mus musculus)
RHEA:46082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADH
REACT:R-HSA-1168640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated IkB is degraded (Homo sapiens)
RHEA:37065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine
GO:0033833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylfurfural reductase (NADH) activity
REACT:R-RNO-75238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL binds TRAIL receptors (Rattus norvegicus)
REACT:R-BTA-5654591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
RHEA:13988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-homoserine <=> ADP + H(+) + O-phospho-L-homoserine
RHEA:11664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)
REACT:R-GGA-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Gallus gallus)
REACT:R-CFA-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Canis familiaris)
RHEA:70451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate
RHEA:38191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:26557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin II + H2O <=> angiotensin-(1-7) + L-phenylalanine
RHEA:56962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a ribonucleoside 5'-triphosphate + pyruvate
REACT:R-HSA-391168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP gamma binds CD47 (Homo sapiens)
REACT:R-BTA-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Bos taurus)
REACT:R-XTR-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:24034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-alpha-D-glucopyranosyl-D-fructose => sucrose
RHEA:17005	skos:prefLabel	"glucuronokinase"
RHEA:17005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronokinase"
RHEA:17005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucuronate = 1-phospho-alpha-D-glucuronate + ADP + H(+)
RHEA:20861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,6R)-isopiperitenol + NAD(+) => (6R)-isopiperitenone + H(+) + NADH
RHEA:31718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Sus scrofa)
REACT:R-CEL-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Caenorhabditis elegans)
REACT:R-RNO-2395324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyrrole cross-links (Rattus norvegicus)
GO:0043801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexulose-6-phosphate synthase activity
GO:0043801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose 6-phosphate
GO:0043801	skos:altLabel	"3-hexulosephosphate synthase"
GO:0043801	skos:altLabel	"3-hexulose phosphate synthase"
GO:0043801	skos:altLabel	"D-arabino-3-hexulose 6-phosphate formaldehyde-lyase"
GO:0043801	skos:altLabel	"HPS"
GO:0043801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hexulose-6-phosphate synthase"
GO:0043801	skos:prefLabel	"3-hexulose-6-phosphate synthase"
REACT:R-RNO-451283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kainate receptor binds glutamate (Rattus norvegicus)
REACT:R-SCE-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Saccharomyces cerevisiae)
RHEA:61745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolbioside + UDP-alpha-D-glucose => stevioside + UDP
RHEA:47503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NADP(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
REACT:R-SSC-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Sus scrofa)
REACT:R-MMU-9624800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LBR (Mus musculus)
REACT:R-HSA-9013986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation (Homo sapiens)
GO:0001588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine neurotransmitter receptor activity, coupled via Gs
GO:0001588	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dopamine D1 receptor activity
GO:0001588	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dopamine D5 receptor activity
REACT:R-HSA-158609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers CH3 from AdoMet to 6MP (Homo sapiens)
RHEA:57961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + H(+) + NADH + O2 => dimethyl sulfoxide + H2O + NAD(+)
REACT:R-SSC-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Sus scrofa)
GO:0005337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside transmembrane transporter activity
GO:0005337	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intracellular nucleoside transmembrane transporter activity
REACT:R-RNO-9692809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the ER membrane (Rattus norvegicus)
RHEA:34840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 5 malonyl-CoA => 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O
RHEA:22501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H(+) + malonyl-CoA => (E)-feruloylacetyl-CoA + CO2 + CoA
REACT:R-XTR-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)
REACT:R-SSC-5660665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 binds MALT (Sus scrofa)
REACT:R-RNO-8985988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Rattus norvegicus)
RHEA:19632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate + NADP(+) <=> 2-oxoglutarate + CO2 + NADPH
RHEA:19620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-450325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-FOS activation by phospho ERK1/2 (Danio rerio)
RHEA:43805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol
REACT:R-DRE-5687088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates MAPKAPK5 (Danio rerio)
RHEA:59463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + NADP(+) <=> H(+) + hexadecanal + NADPH
REACT:R-GGA-5687091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 binds MAPKAPK5 (Gallus gallus)
RHEA:37022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-serine + H2O <=> 3-hydroxypyruvate + AH2 + NH4(+)
RHEA:30054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetate + H2O <=> fluoride + glycolate + H(+)
RHEA:41392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)
RHEA:17950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-1H-quinolin-4-one + O2 => CO + H(+) + N-formylanthranilate
RHEA:34457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-beta-carotene => all-trans-beta-carotene
GO:0102599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity
REACT:R-XTR-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Xenopus tropicalis)
RHEA:35184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxythiophene-2-carbonyl-CoA + H2O => 4-carboxy-2-thioxobutanoyl-CoA
REACT:R-DME-9718394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide antagonists (Drosophila melanogaster)
REACT:R-SSC-914012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Sus scrofa)
GO:0062153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5-methylcytosine-containing RNA binding
GO:0062153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5-methylcytidine-containing RNA binding
REACT:R-MMU-141422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 converted  to an inhibitory state via interaction with Mad1 (Mus musculus)
GO:0008519	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonia transmembrane transporter activity
GO:0008519	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonium channel activity
GO:0008519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammonium transmembrane transporter activity
REACT:R-HSA-6797653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMGDH:FAD oxidatively demethylates DMGLY to SARC (Homo sapiens)
REACT:R-BTA-114697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)
REACT:R-DME-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Drosophila melanogaster)
REACT:R-CFA-9648949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A antagonists bind HTR3A pentamer (Canis familiaris)
REACT:R-RNO-2681667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Rattus norvegicus)
REACT:R-MMU-2685505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPCN1/2 transport lysosomal Ca2+ to cytosol  (Mus musculus)
REACT:R-DRE-5336182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37 binds prosaptide (Danio rerio)
REACT:R-CEL-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
RHEA:20832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type guanine transporter"
RHEA:20832	skos:prefLabel	"ABC-type guanine transporter"
RHEA:20832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanine(out) + H2O = ADP + guanine(in) + H(+) + phosphate
RHEA:20832	skos:altLabel	"guanine-transporting ATPase"
REACT:R-XTR-264679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serum albumin binds 2-lysophosphatidylcholine (Xenopus tropicalis)
RHEA:53725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate
REACT:R-CFA-204008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC31:SEC13 and v-SNARE recruitment (Canis familiaris)
REACT:R-DME-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Drosophila melanogaster)
RHEA:45429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate
RHEA:46918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + juvenile hormone I carboxylate + methanol => H2O + juvenile hormone I
RHEA:66928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)
REACT:R-GGA-2128994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Gallus gallus)
REACT:R-GGA-3788061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by ADAM8 (Gallus gallus)
REACT:R-DRE-352232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Danio rerio)
REACT:R-RNO-1564169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VIII degradation by MMP1 (Rattus norvegicus)
REACT:R-CEL-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-XTR-9014467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the ER membrane (Xenopus tropicalis)
RHEA:38216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + NAD(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADH
RHEA:27829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-succinyl-L-homoserine <=> L-homocysteine + succinate
REACT:R-RNO-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Rattus norvegicus)
RHEA:69169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + spermine monoaldehyde => 2 H(+) + N-(2-carboxyethyl)spermidine + NADH
RHEA:59922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoate + 2 H(+) + NADH => (2E)-octenal + H2O + NAD(+)
RHEA:58707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin hemiaminal <=> rifampicin ortho-naphthoquinone carboxamide
RHEA:63173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oyl-CoA => (25R)-3-oxocholest-4-en-26-oyl-CoA
RHEA:40406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
GO:0008851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethanolamine deaminase activity
GO:0008851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine ammonia-lyase activity
GO:0008851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethanolamine ammonia-lyase (acetaldehyde-forming) activity
REACT:R-HSA-9029680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-7 translocates to the nucleus (Homo sapiens)
REACT:R-CEL-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
REACT:R-GGA-6781922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds UFD1L:SKP2 (Gallus gallus)
REACT:R-MMU-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Mus musculus)
RHEA:21558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine => [calmodulin]-L-lysine + S-adenosyl-L-methionine
RHEA:53595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycerol 3-phosphate + H2O <=> 1-tetradecanoyl-sn-glycerol + phosphate
REACT:R-SSC-140783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Sus scrofa)
GO:0008874	skos:altLabel	"5-ketogluconate 5-reductase"
GO:0008874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gluconate 5-dehydrogenase activity
GO:0008874	skos:altLabel	"5-keto-D-gluconate 5-reductase"
GO:0008874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-keto-D-gluconate 5-reductase activity
GO:0008874	skos:prefLabel	"gluconate 5-dehydrogenase"
GO:0008874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH
GO:0008874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-ketogluconate reductase activity
GO:0008874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-keto-D-gluconate reductase
GO:0008874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-ketogluconate 5-reductase activity
GO:0008874	skos:altLabel	"5-ketogluconate reductase"
GO:0008874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-gluconate:NAD(P)+ 5-oxidoreductase
GO:0008874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gluconate 5-dehydrogenase"
GO:0008874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH
REACT:R-MMU-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Mus musculus)
REACT:R-XTR-1470012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus (Xenopus tropicalis)
REACT:R-SSC-933533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of p-IRF7 (Sus scrofa)
REACT:R-DRE-75244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL binds FAS Receptor (Danio rerio)
REACT:R-XTR-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)
RHEA:70746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-372697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binding to p130cas (Homo sapiens)
REACT:R-DME-5654571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS3 (Drosophila melanogaster)
RHEA:66610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate) => (tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O
RHEA:53965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin => gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]
REACT:R-BTA-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Bos taurus)
RHEA:15058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-[ACP] + H2O => (9Z)-octadecenoate + H(+) + holo-[ACP]
REACT:R-XTR-442387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP8 mediates zinc influx into cells (Xenopus tropicalis)
RHEA:21445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-hydroxyphenyl)propanoate + NAD(+) => H(+) + NADH + trans-2-coumarate
REACT:R-GGA-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Gallus gallus)
RHEA:45823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mesaconate + succinyl-CoA <=> 2-methylfumaryl-CoA + succinate
RHEA:17664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + succinate <=> ADP + phosphate + succinyl-CoA
REACT:R-RNO-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Rattus norvegicus)
REACT:R-HSA-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Homo sapiens)
RHEA:29133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + menaquinone-8 + nitrite => menaquinol-8 + nitrate
REACT:R-RNO-2453833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Rattus norvegicus)
REACT:R-GGA-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Gallus gallus)
RHEA:20016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + L-aspartate <=> H(+) + N-carbamoyl-L-aspartate + phosphate
REACT:R-DME-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Drosophila melanogaster)
RHEA:37489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine
RHEA:37753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-cis-aconitate => 2-methyl-trans-aconitate
GO:0102476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pinocembrin 2-hydroxylase activity
RHEA:63537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bradykinin(1-8) + H2O => bradykinin(1-7) + L-phenylalanine
RHEA:18189	skos:altLabel	"glycogen synthase"
RHEA:18189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)
RHEA:18189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"starch synthase"
RHEA:18189	skos:altLabel	"ADP-glucose--starch glucosyltransferase"
RHEA:18189	skos:altLabel	"starch (bacterial glycogen) synthase"
RHEA:18189	skos:prefLabel	"starch synthase"
GO:0030116	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glial cell line-derived neurotrophic factor receptor ligand
GO:0030116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glial cell line-derived neurotrophic factor receptor binding
GO:0030116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glial cell-derived neurotrophic factor receptor binding
GO:0050185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol deacylase"
GO:0050185	skos:altLabel	"Phosphatidylinositol phospholipase A2"
GO:0050185	skos:prefLabel	"phosphatidylinositol deacylase"
GO:0050185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol deacylase activity
GO:0050185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)
GO:0050185	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylinositol phospholipase A2 activity
GO:0050185	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity
RHEA:40980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate
REACT:R-GGA-373073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR1, 2 and 8 bind CCL16 ligand (Gallus gallus)
RHEA:20418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine + O2 => CO2 + coelenteramide + hnu
REACT:R-HSA-6793978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of STAT6-upregulated extracellular proteins (Homo sapiens)
REACT:R-SSC-8953398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIR oxygenates quercetin (Sus scrofa)
REACT:R-HSA-9733207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter (Homo sapiens)
REACT:R-HSA-9008267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds to TGFA gene promoter (Homo sapiens)
REACT:R-RNO-1112565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Rattus norvegicus)
RHEA:56205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)
RHEA:52303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Mus musculus)
RHEA:34677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N,N-diacetyllegionaminate + diphosphate => CTP + N,N-diacetyllegionaminate
RHEA:58332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH
RHEA:61646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + H2O + L-arginine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine
RHEA:36041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+)
REACT:R-DRE-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Danio rerio)
RHEA:44123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + octadecan-1-ol <=> CoA + octadecanyl hexadecanoate
RHEA:72865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G[3'-5']pA[3'-5']pAp[3'] + H(+) => 3',3',3'-cAAG + H2O
RHEA:49527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 <=> a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate
RHEA:41515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + NADH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NAD(+)
RHEA:43992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 = 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)
RHEA:64996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + octanoate = diphosphate + octanoyl-AMP
REACT:R-PFA-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Plasmodium falciparum)
RHEA:20014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + L-aspartate => H(+) + N-carbamoyl-L-aspartate + phosphate
GO:0033201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-glucan synthase activity
GO:0033201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,4-glucan synthase activity
RHEA:38376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacterioruberin => bisanhydrobacterioruberin + 2 H2O
REACT:R-GGA-173631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1s (Gallus gallus)
REACT:R-XTR-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Xenopus tropicalis)
REACT:R-CEL-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Caenorhabditis elegans)
GO:0046574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronyl hydrolase activity
GO:0046574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycuronidase activity
REACT:R-MMU-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Mus musculus)
RHEA:49669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NAD(+)
RHEA:50764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-amino-anhydrotetracycline N(4)-methyltransferase"
RHEA:50764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine
RHEA:50764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine
RHEA:50764	skos:prefLabel	"4-amino-anhydrotetracycline N(4)-methyltransferase"
GO:0032032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin I tail binding
REACT:R-GGA-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Gallus gallus)
REACT:R-BTA-211193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization  of DFF40 (Bos taurus)
REACT:R-HSA-5669013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA-3 binds EDA2R (Homo sapiens)
REACT:R-RNO-2187309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer binds SP1 (Rattus norvegicus)
REACT:R-CFA-9793988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates CFLAR at K351, K353 (Canis familiaris)
REACT:R-SSC-9021609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR-associated SRC autophosphorylates (Sus scrofa)
RHEA:41881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-[ACP] + H(+) + NADPH => dodecanoyl-[ACP] + NADP(+)
REACT:R-GGA-1250353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Gallus gallus)
REACT:R-HSA-3215448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Homo sapiens)
REACT:R-HSA-1483099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA translocates from the outer to the inner mitochondrial membrane (Homo sapiens)
RHEA:49346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:44114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + nonyl hexadecanoate => hexadecanoyl-CoA + nonan-1-ol
REACT:R-HSA-168891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of NS1 to dsRNA (Homo sapiens)
GO:0034979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent protein deacetylase activity
REACT:R-GGA-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Gallus gallus)
REACT:R-DME-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
REACT:R-GGA-6803063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial LPS, PGN (Gallus gallus)
REACT:R-HSA-2730864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TRAF6 to CBM complex by binding to MALT1 (Homo sapiens)
RHEA:67841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid A disaccharide + ATP => a lipid IVA + ADP + H(+)
EC:2.7.1.76	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyadenosine kinase"
EC:2.7.1.76	skos:prefLabel	"deoxyadenosine kinase"
RHEA:68833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate + H2O => (6Z)-nerolidol + diphosphate
REACT:R-MMU-4086132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin phosphoprotein binds integrin alphaVbeta1 (Mus musculus)
GO:0047732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoabequose epimerase activity
GO:0047732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphodideoxyglucose epimerase activity
GO:0047732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-paratose epimerase activity
GO:0047732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoparatose epimerase activity
GO:0047732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-3,6-dideoxy-D-glucose 2-epimerase activity
GO:0047732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-paratose 2-epimerase activity
GO:0047732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphate paratose-2-epimerase activity
GO:0047732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-abequose epimerase activity
GO:0047732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-D-abequose 2-epimerase activity
GO:0047732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-tyvelose 2-epimerase activity
REACT:R-RNO-6790487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 ubiquitinates SUMOylated XPC (Rattus norvegicus)
RHEA:61470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine
RHEA:48604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)
REACT:R-MMU-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)
RHEA:57060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)
REACT:R-GGA-9015111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors binds Xa (Gallus gallus)
REACT:R-SCE-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Saccharomyces cerevisiae)
REACT:R-SSC-202248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma1 (Sus scrofa)
REACT:R-SSC-8856157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAG3 (CD233) binds MHC II (Sus scrofa)
REACT:R-CFA-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Canis familiaris)
RHEA:19352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4-dehydropantoate + H2O + NAD(+) <=> (R)-3,3-dimethylmalate + 2 H(+) + NADH
RHEA:38752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate
REACT:R-DDI-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)
REACT:R-BTA-6786124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3,STAT6 bind p-Y-IL4R (Bos taurus)
RHEA:57166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2
RHEA:68095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA <=> a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)
RHEA:49870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid ketone + a quinol => (+)-dehydrodiconiferyl acid + a quinone
RHEA:43027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteine <=> 2-aminoprop-2-enoate + a thiol
GO:0102656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity
RHEA:53820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NADP(+) = 7-oxolithocholate + H(+) + NADPH
RHEA:11485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + 2 Fe(III)-[cytochrome c](out) => a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
RHEA:61202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]
RHEA:23343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-oct-2-ulosonate <=> D-arabinose + pyruvate
REACT:R-CFA-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Canis familiaris)
REACT:R-SSC-166175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Sus scrofa)
RHEA:64453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine
REACT:R-HSA-532603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin mediated activation of N-WASP (Homo sapiens)
RHEA:40710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:66956	skos:prefLabel	"GDP-mannose:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,4-mannosyltransferase"
RHEA:66956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-mannose:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,4-mannosyltransferase"
RHEA:66956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
RHEA:38323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol
GO:0001639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase C activating metabotropic glutamate receptor activity
GO:0001639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC activating G protein-coupled glutamate receptor activity
GO:0001639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC activating G-protein coupled glutamate receptor activity
GO:0001639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	group I metabotropic glutamate receptor activity
GO:0001639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC activating metabotropic glutamate receptor activity
GO:0001639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Group I metabotropic glutamate receptor
GO:0015227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Homo sapiens)
GO:0015227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl carnitine transmembrane transporter activity
GO:0015227	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acylcarnitine transporter activity
REACT:R-MMU-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Mus musculus)
RHEA:22477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH
RHEA:59373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)
RHEA:55368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnitine monooxygenase"
RHEA:55368	skos:prefLabel	"carnitine monooxygenase"
RHEA:55368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine
RHEA:55368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine
RHEA:39941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-XTR-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Xenopus tropicalis)
GO:0032791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lead ion binding
REACT:R-MMU-5205649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 links damaged mitochondria to LC3 (Mus musculus)
RHEA:56198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose
RHEA:24334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monacolin L carboxylate => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate
RHEA:37596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:40274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecanedioyl-CoA <=> (2E)-tetradecenedioyl-CoA + H2O2
RHEA:29288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + L-aspartate(in) => 2 H(+)(out) + L-aspartate(out)
REACT:R-MMU-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Mus musculus)
REACT:R-MMU-9008285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Mus musculus)
GO:0102765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-D-apiose synthase activity
REACT:R-RNO-8944233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIX (Rattus norvegicus)
REACT:R-SSC-8877813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND5A,B exchange GTP for GDP on RAB39 (Sus scrofa)
RHEA:42948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-9609743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Rattus norvegicus)
REACT:R-SPO-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Schizosaccharomyces pombe)
REACT:R-RNO-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Rattus norvegicus)
RHEA:58750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nectriapyrone + S-adenosyl-L-homocysteine => desmethylnectriapyrone + S-adenosyl-L-methionine
REACT:R-GGA-349637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spherical HDL and SR-BI receptor form a complex at the cell surface (Gallus gallus)
RHEA:70352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O => beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose
REACT:R-SSC-8848939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds KHDRBS1 (Sus scrofa)
REACT:R-CEL-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Caenorhabditis elegans)
RHEA:15361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-alpha-D-xylose = a dolichyl D-xylosyl phosphate + UDP
RHEA:15361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-phosphate D-xylosyltransferase"
RHEA:15361	skos:prefLabel	"dolichyl-phosphate D-xylosyltransferase"
RHEA:59392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-seryl-[protein] = CoA + O-acetyl-L-seryl-[protein]
REACT:R-HSA-444859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)
RHEA:14420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + L-lysine <=> H(+) + N(6)-acetyl-L-lysine + phosphate
REACT:R-SSC-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Sus scrofa)
RHEA:17536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-glutamate
REACT:R-RNO-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Rattus norvegicus)
GO:0034000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin sulfate ABC endolyase activity
GO:0034000	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinase activity
GO:0034000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin-sulfate-ABC endolyase activity
GO:0034000	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinase ABC activity
GO:0034000	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitin sulfate ABC lyase activity
GO:0034000	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ChS ABC lyase activity
GO:0034000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin sulfate ABC endoeliminase activity
GO:0034000	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitin ABC eliminase activity
GO:0034000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ChS ABC lyase I activity
RHEA:72227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + sarcosine(out) = chloride(in) + 2 Na(+)(in) + sarcosine(in)
RHEA:29349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + orotate(out) => 2 H(+)(in) + orotate(in)
REACT:R-HSA-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Homo sapiens)
REACT:R-HSA-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Homo sapiens)
REACT:R-MMU-2464809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates the transport of atROL from ROS to RPE (Mus musculus)
RHEA:52512	skos:prefLabel	"hydroxyproline dehydrogenase"
RHEA:52512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyproline dehydrogenase"
RHEA:52512	skos:altLabel	"HYPDH"
RHEA:52512	skos:altLabel	"hydroxyproline oxidase"
RHEA:52512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + trans-4-hydroxy-L-proline = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
RHEA:56696	skos:prefLabel	"L-tryptophan isonitrile synthase"
RHEA:56696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + L-tryptophan = (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate
RHEA:56696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-tryptophan isonitrile synthase"
GO:0031713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	B2 bradykinin receptor ligand
GO:0031713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B2 bradykinin receptor binding
REACT:R-XTR-75244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL binds FAS Receptor (Xenopus tropicalis)
RHEA:26138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
REACT:R-PFA-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Plasmodium falciparum)
REACT:R-MMU-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Mus musculus)
RHEA:67509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-9620663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1 binds the VGF gene (Homo sapiens)
GO:0008913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl transferase activity
GO:0008913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyltransferase activity
GO:0001069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	regulatory region RNA binding
GO:0000234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoethanolamine N-methyltransferase activity
GO:0000234	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoethanolamine methyltransferase activity
GO:0000234	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity
REACT:R-SSC-114254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS binds to APAF1 (Sus scrofa)
REACT:R-CEL-400682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Rac1 interacts with Plexin-B1:Sema4D (Caenorhabditis elegans)
REACT:R-HSA-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Homo sapiens)
REACT:R-BTA-8987236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Bos taurus)
REACT:R-DRE-2172678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates histone H4K20me1 (Danio rerio)
REACT:R-RNO-2423785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR:atREs binds apoE and HSPG (Rattus norvegicus)
RHEA:55588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide
REACT:R-CFA-5693599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Ku heterodimer with ends of DNA double-strand break (Canis familiaris)
REACT:R-BTA-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Bos taurus)
RHEA:59137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + D-ornithine => AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine
RHEA:16234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + NADP(+) => 2-dehydropantoate + H(+) + NADPH
RHEA:66916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->3)-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose
REACT:R-GGA-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
REACT:R-DME-5618098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Drosophila melanogaster)
REACT:R-DRE-265153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Danio rerio)
REACT:R-MMU-977363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3bBb (Mus musculus)
REACT:R-GGA-381487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP1 binds IGF forming IGF:IGFBP1 (Gallus gallus)
RHEA:15284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol <=> 5alpha-cholest-8-en-3beta-ol
REACT:R-DRE-167429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex  binds GTP (Danio rerio)
REACT:R-XTR-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Xenopus tropicalis)
REACT:R-SSC-9018907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Sus scrofa)
RHEA:61034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine
REACT:R-MMU-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Mus musculus)
REACT:R-HSA-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Homo sapiens)
REACT:R-MMU-5635102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 is internalized (Mus musculus)
REACT:R-DME-5669250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates FLNA (Drosophila melanogaster)
GO:0052577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacrene-D synthase activity
GO:0052577	skos:prefLabel	"(-)-germacrene D synthase"
GO:0052577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate
GO:0052577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-germacrene D synthase"
GO:0052577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene D-forming] activity
REACT:R-CFA-390912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds hist (Canis familiaris)
RHEA:67142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2
REACT:R-MMU-114684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Syntaxin-4 (Mus musculus)
REACT:R-XTR-2022052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Xenopus tropicalis)
REACT:R-CFA-6783681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIF binds LIFR (Canis familiaris)
REACT:R-BTA-9670014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor VIIIa dissociates  (Bos taurus)
RHEA:60463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
REACT:R-HSA-9008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylation (Homo sapiens)
RHEA:14544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + H2O <=> cholate + CoA + H(+)
REACT:R-BTA-168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNKs phosphorylate c-JUN (Bos taurus)
REACT:R-HSA-1247915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSH translocates from cytosol to extracellular region (Homo sapiens)
REACT:R-DME-4720432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Drosophila melanogaster)
REACT:R-RNO-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Rattus norvegicus)
RHEA:67417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Bos taurus)
RHEA:19893	skos:altLabel	"phosphomethylpyrimidine kinase"
RHEA:19893	skos:altLabel	"hydroxymethylpyrimidine phosphokinase"
RHEA:19893	skos:prefLabel	"phosphooxymethylpyrimidine kinase"
RHEA:19893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphooxymethylpyrimidine kinase"
RHEA:19893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP
REACT:R-HSA-8944497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN mRNA translation is negatively regulated by microRNAs (Homo sapiens)
RHEA:50847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
RHEA:13236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + phosphate <=> alpha-D-ribose 1-phosphate + guanine
REACT:R-BTA-1592371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP3 (Bos taurus)
REACT:R-MMU-6783530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gp130:JAKs bind CNTFR (Mus musculus)
REACT:R-HSA-9695841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 mutant dimers bind GRB2 (Homo sapiens)
REACT:R-RNO-6797961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHDH oxidises Cho to BETALD (Rattus norvegicus)
REACT:R-MMU-2028284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Mus musculus)
REACT:R-CEL-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Caenorhabditis elegans)
RHEA:71487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Leu-enkephalin = L-phenylalanyl-L-leucine + L-tyrosylglycylglycine
RHEA:18320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid <=> a D-alpha-amino acid
REACT:R-BTA-158800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Bos taurus)
REACT:R-BTA-8877153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 binds PC (Bos taurus)
RHEA:53000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-HSA-3700981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind the BAX promoter (Homo sapiens)
REACT:R-HSA-8873850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD5 binds DCA, LCA (Homo sapiens)
REACT:R-SPO-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Schizosaccharomyces pombe)
RHEA:69052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrosourea synthase"
RHEA:69052	skos:prefLabel	"nitrosourea synthase"
RHEA:69052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 = 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)
REACT:R-GGA-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Gallus gallus)
RHEA:33830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol <=> vitamin D2
REACT:R-SSC-9027281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Sus scrofa)
REACT:R-DRE-3296126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Danio rerio)
REACT:R-DDI-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)
RHEA:69649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + quercetin => H2O + quercetin 4'-O-beta-D-glucoside
RHEA:71086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + 2 Na(+)(out) <=> estrone 3-sulfate(in) + 2 Na(+)(in)
RHEA:31140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH
REACT:R-MMU-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Mus musculus)
REACT:R-MMU-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Mus musculus)
REACT:R-RNO-8852298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Rattus norvegicus)
REACT:R-DRE-5357757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC(cIAP1/2) ubiquitinates RIPK1 (Danio rerio)
RHEA:20164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose <=> myo-inositol + raffinose
REACT:R-HSA-1964496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds TRIM32 or TRIM56  (Homo sapiens)
RHEA:28942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + xanthosine(in) <=> H(+)(out) + xanthosine(out)
RHEA:32543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = 1,8-cineole + diphosphate
RHEA:32543	skos:altLabel	"1,8-cineole cyclase"
RHEA:32543	skos:prefLabel	"1,8-cineole synthase"
RHEA:32543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,8-cineole synthase"
REACT:R-DRE-5654169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 (Danio rerio)
RHEA:70052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate
REACT:R-MMU-8944247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VI (Mus musculus)
RHEA:34917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(out) => D-galactose(in)
RHEA:26278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-4 + S-adenosyl-L-methionine => Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-8987129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Mus musculus)
REACT:R-DRE-3000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PLK1 (Danio rerio)
RHEA:25873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + pyridine => H2O + pyridine N-oxide
REACT:R-XTR-1667005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Xenopus tropicalis)
RHEA:23426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine 6-phosphate => alpha-D-glucosamine 1-phosphate
REACT:R-CEL-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Caenorhabditis elegans)
GO:0036094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small molecule binding
REACT:R-SSC-937032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
RHEA:42229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + A => AH2 + estrone
REACT:R-BTA-1254251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds YAP1 (Bos taurus)
REACT:R-RNO-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Rattus norvegicus)
REACT:R-RNO-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Rattus norvegicus)
REACT:R-DRE-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Danio rerio)
RHEA:23921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate
REACT:R-BTA-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Bos taurus)
REACT:R-SSC-205262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Direct recruitment of PI3K to p-KIT (Sus scrofa)
REACT:R-DRE-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Danio rerio)
REACT:R-SSC-193497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Sus scrofa)
RHEA:47340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-4395227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CREBBP binds NOTCH1 promoter (Homo sapiens)
REACT:R-RNO-6781899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds SIAH2 (Rattus norvegicus)
GO:0009982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PUS7 transforms uridine to pseudouridine in tRNAs (Homo sapiens)
GO:0009982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine synthase activity
RHEA:25104	skos:altLabel	"vitamin B(6) kinase"
RHEA:25104	skos:altLabel	"vitamin B6 kinase"
RHEA:25104	skos:prefLabel	"pyridoxal kinase"
RHEA:25104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxal kinase"
RHEA:25104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate
RHEA:25104	skos:altLabel	"pyridoxamine kinase"
RHEA:25104	skos:altLabel	"pyridoxine kinase"
RHEA:30269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate + L-dehydroascorbate => 2 monodehydro-L-ascorbate radical
REACT:R-DRE-391936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP1 receptor can bind PGE2 (Danio rerio)
REACT:R-DME-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Drosophila melanogaster)
REACT:R-CFA-9693978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Small molecule inhibitor binds RIPK1, RIPK3 (Canis familiaris)
REACT:R-DDI-9014296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GEFs activate RAC2 (Dictyostelium discoideum)
REACT:R-SCE-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Saccharomyces cerevisiae)
REACT:R-DRE-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Danio rerio)
REACT:R-MMU-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Mus musculus)
REACT:R-CEL-450474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates BRF1 (Caenorhabditis elegans)
REACT:R-MMU-8864125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Mus musculus)
RHEA:51424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate
REACT:R-CFA-879584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO3A1 isoform 1 has abroad substrate specificity (Canis familiaris)
REACT:R-SSC-8942302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP13 cleaves OPTC (Sus scrofa)
RHEA:43180	skos:prefLabel	"25S rRNA (cytosine(2278)-C(5))-methyltransferase"
RHEA:43180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"25S rRNA (cytosine(2278)-C(5))-methyltransferase"
RHEA:43180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:26166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-hydroxyechinenone + A + H2O => AH2 + echinenone + O2
RHEA:32947	skos:prefLabel	"2-acylglycerol O-acyltransferase"
RHEA:32947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
RHEA:32947	skos:altLabel	"monoglyceride acyltransferase"
RHEA:32947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-acylglycerol O-acyltransferase"
RHEA:32947	skos:altLabel	"acylglycerol palmitoyltransferase"
RHEA:30449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + NAD(+) + xanthine => 3-methylxanthine + H(+) + NADH + O2
REACT:R-HSA-5654148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR3 (Homo sapiens)
REACT:R-MMU-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Mus musculus)
REACT:R-DRE-5229111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 transports APP from trans-Golgi network to endosome lumen (Danio rerio)
REACT:R-HSA-5601924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Primary piRNA transcript translocates from nucleoplasm to cytosol (Homo sapiens)
REACT:R-MMU-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Mus musculus)
RHEA:62435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in tRNA + S-adenosyl-L-methionine <=> a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine
REACT:R-CFA-418845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of caspase-3 (Canis familiaris)
REACT:R-MMU-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Mus musculus)
RHEA:30474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> (1S,5S,6S)-alpha-bergamotene + diphosphate
RHEA:49893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2
RHEA:34748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine + ATP => 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)
REACT:R-CFA-174445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap on the C-strand (Canis familiaris)
RHEA:36352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine
RHEA:54306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate
RHEA:30172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]
REACT:R-XTR-217258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO2:FAD:Mg2+ S-oxidises MTZ (Xenopus tropicalis)
REACT:R-BTA-8852280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds microtubule lattice in interphase cells (Bos taurus)
RHEA:11704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N-(carboxyaminomethyl)urea = CO2 + N-(aminomethyl)urea
EC:3.4.22.48	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"staphopain"
EC:3.4.22.48	skos:altLabel	"staphylopain"
EC:3.4.22.48	skos:prefLabel	"staphopain"
REACT:R-HSA-9011748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R binds JAK1 (Homo sapiens)
EC:2.4.99.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyllactosaminide alpha-2,3-sialyltransferase"
EC:2.4.99.6	skos:altLabel	"neolactotetraosylceramide alpha-2,3-sialyltransferase"
EC:2.4.99.6	skos:prefLabel	"N-acetyllactosaminide alpha-2,3-sialyltransferase"
RHEA:11647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH
RHEA:18821	skos:altLabel	"choline acetylase"
RHEA:18821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choline O-acetyltransferase"
RHEA:18821	skos:altLabel	"CHOACTase"
RHEA:18821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + choline = acetylcholine + CoA
RHEA:18821	skos:prefLabel	"choline O-acetyltransferase"
REACT:R-DME-165131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEF dissociates from DRheb-GTP (Drosophila melanogaster)
GO:0033944	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-galactofuranoside hydrolase activity
GO:0033944	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-galactofuranosidase activity
GO:0033944	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-D-galactofuranosidase activity
GO:0033944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-galactofuranosidase activity
GO:0033944	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-galactofuranosidase activity
RHEA:68109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glucitol + NAD(+) => H(+) + keto-L-fructose + NADH
EC:1.6.1.1	skos:prefLabel	"NAD(P)(+) transhydrogenase (Si-specific)"
EC:1.6.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(P)(+) transhydrogenase (Si-specific)"
EC:1.6.1.1	skos:altLabel	"NAD(P)(+) transhydrogenase (B-specific)"
EC:1.6.1.1	skos:altLabel	"pyridine nucleotide transhydrogenase"
EC:1.6.1.1	skos:altLabel	"nicotinamide nucleotide transhydrogenase"
REACT:R-CFA-389026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galanin receptors can bind galanin (Canis familiaris)
REACT:R-MMU-442291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV2 is a GEF for Rho/Rac family kinases (Mus musculus)
REACT:R-BTA-4341070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PPARA with SUMO1 (Bos taurus)
RHEA:32540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (+)-car-3-ene + diphosphate
EC:3.2.-.-	skos:prefLabel	"Glycosylases"
EC:3.2.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Glycosylases"
RHEA:48958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-3-iodo-L-tyrosine + 2 H2O => [thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide
RHEA:43229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine
GO:0031734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR9 chemokine receptor binding
GO:0031734	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR9 chemokine receptor ligand
REACT:R-DME-5654573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds SHC1 (Drosophila melanogaster)
REACT:R-HSA-8874186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L4 (Homo sapiens)
REACT:R-HSA-4608852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)
REACT:R-BTA-176175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Stalling of DNA replication fork and RPA binding (Bos taurus)
REACT:R-HSA-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Homo sapiens)
REACT:R-DME-9018785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds GTP (Drosophila melanogaster)
REACT:R-SSC-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Sus scrofa)
REACT:R-HSA-5654730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Homo sapiens)
REACT:R-DRE-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Danio rerio)
REACT:R-GGA-382061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular processing of novel PDGFs (Gallus gallus)
REACT:R-HSA-2730861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Homo sapiens)
REACT:R-DRE-9714924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to soluble TNF trimer (Danio rerio)
REACT:R-HSA-1855164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 transports from the cytosol to the ER lumen (Homo sapiens)
REACT:R-RNO-8987105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Rattus norvegicus)
RHEA:67499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end CoA-ribonucleoside in mRNA + H2O <=> 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)
REACT:R-CFA-9009308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 polyubiquitinates RUNX2 (Canis familiaris)
RHEA:63012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + orsellinate = diphosphate + ilicicolinate B
RHEA:51327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate
RHEA:34835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine = a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine
REACT:R-SSC-5607733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 binds CARD9 (Sus scrofa)
REACT:R-XTR-5205649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 links damaged mitochondria to LC3 (Xenopus tropicalis)
RHEA:19349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4-dehydropantoate + H2O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH
RHEA:19349	skos:prefLabel	"(R)-dehydropantoate dehydrogenase"
RHEA:19349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-dehydropantoate dehydrogenase"
RHEA:19349	skos:altLabel	"D-aldopantoate dehydrogenase"
RHEA:17346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + H2O => CoA + H(+) + methylmalonate
REACT:R-DME-1483096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA is dephosphorylated to ETA by PHOSPHO1 (Drosophila melanogaster)
REACT:R-MMU-8944262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type X (Mus musculus)
REACT:R-CFA-6814670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Canis familiaris)
REACT:R-SPO-109857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 binds MAPK3 (Schizosaccharomyces pombe)
REACT:R-XTR-2248891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARSA translocates to the lysosome (Xenopus tropicalis)
RHEA:52307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-ectoine <=> (2S)-2-acetamido-4-aminobutanoate
REACT:R-HSA-6783524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)
RHEA:40024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate + H2O => diphosphate + syn-copalol
GO:0047937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphodismutase activity
GO:0047937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-glucopyranose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate
GO:0047937	skos:prefLabel	"glucose-1-phosphate phosphodismutase"
GO:0047937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity
GO:0047937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-1-phosphate phosphodismutase"
GO:0047937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose 1-phosphate transphosphorylase activity
GO:0047937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-1-phosphate phosphodismutase activity
REACT:R-BTA-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Bos taurus)
REACT:R-MMU-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Mus musculus)
RHEA:36604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-enduracididine + O2 => (3S)-3-hydroxy-L-enduracididine + CO2 + succinate
RHEA:54804	skos:prefLabel	"4,4'-dithiodibutanoate disulfide reductase"
RHEA:54804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4,4'-dithiodibutanoate disulfide reductase"
RHEA:54804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 4-sulfanylbutanoate + NAD(+) = 4,4'-disulfanyldibutanoate + H(+) + NADH
GO:0050244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate oxidase (CoA-acetylating) activity
GO:0050244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)
REACT:R-PFA-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Plasmodium falciparum)
RHEA:46381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:49482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-2-aminoadipate + NADPH => 2 H2O + L-1-piperideine-6-carboxylate + NADP(+)
REACT:R-MMU-194121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-CFA-9757954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4BP1 binds IKBKG (Canis familiaris)
REACT:R-HSA-5602472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective IRAK4 does not form a complex with MyD88 within the TLR5 complex (Homo sapiens)
RHEA:25298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH
REACT:R-HSA-9635915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF4 and CEBPB,CEBPG bind the ASNS gene (Homo sapiens)
REACT:R-MMU-6813626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEAP2 binds bacteria (Mus musculus)
REACT:R-CFA-9021660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds membrane-associated estrogen receptors (Canis familiaris)
REACT:R-CFA-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Canis familiaris)
RHEA:25949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CTP => a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)
RHEA:44616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)
REACT:R-SSC-170055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Sus scrofa)
RHEA:36120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A9 + S-adenosyl-L-methionine => O-methyl gibberellin A9 + S-adenosyl-L-homocysteine
REACT:R-SCE-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Saccharomyces cerevisiae)
RHEA:37429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate
RHEA:47120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + glycine = H2O + N-docosanoylglycine
REACT:R-BTA-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Bos taurus)
REACT:R-CEL-390846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2D3,4 bind to DA (Caenorhabditis elegans)
REACT:R-GGA-166175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Gallus gallus)
REACT:R-CFA-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Canis familiaris)
REACT:R-DRE-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Danio rerio)
REACT:R-RNO-8964333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Rattus norvegicus)
REACT:R-PFA-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Plasmodium falciparum)
REACT:R-CFA-173680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C5 (Canis familiaris)
REACT:R-SCE-8851538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)
REACT:R-HSA-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
RHEA:29804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-valine(out) => ADP + H(+) + L-valine(in) + phosphate
REACT:R-DRE-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Danio rerio)
GO:0018532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity
GO:0018532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity
GO:0018532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-independent methylene-H4MPT dehydrogenase activity
GO:0018532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420-independent methylene-H4MPT dehydrogenase activity
GO:0018532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity
RHEA:37616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-HSA-917744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)
REACT:R-RNO-444171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR2 binds carboxylates (Rattus norvegicus)
RHEA:44120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + octadecan-1-ol = CoA + octadecanyl hexadecanoate
RHEA:57541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NTP-ribonucleotide-RNA + H2O => a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)
REACT:R-RNO-388832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds CD28 (Rattus norvegicus)
REACT:R-HSA-8853801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPN binds RET:GFRA4 (Homo sapiens)
REACT:R-MMU-2032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ), TBX5, and PCAF form a complex (Mus musculus)
REACT:R-GGA-6786171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 deubiquitination by USP1:WDR48 (Gallus gallus)
REACT:R-MMU-5682826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM11 (Mus musculus)
RHEA:55769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + UDP-alpha-D-glucuronate => all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP
RHEA:46719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine
REACT:R-SSC-9627078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP9 (Sus scrofa)
RHEA:21774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + uridine(6666) in apoB mRNA => cytidine(6666) in apoB mRNA + H(+) + H2O
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD254 binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ODF binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tumor necrosis factor (ligand) superfamily member 11 binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPGL binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tumor necrosis factor ligand superfamily member 11 binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor activator of nuclear factor kappa-B ligand binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANKL binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRANCE binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tumor necrosis factor superfamily member 11 binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	osteoclast differentiation factor binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF11 binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-related activation-induced cytokine binding
GO:0038057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	osteoprotegerin ligand binding
REACT:R-HSA-5423678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 hydroxylates AFB1 to AFM1 (Homo sapiens)
REACT:R-CFA-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Canis familiaris)
RHEA:26457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADPH
REACT:R-SSC-8983063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Sus scrofa)
RHEA:67763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
RHEA:28647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetophenone + 2 ATP + H2O + hydrogencarbonate = 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate
RHEA:28647	skos:prefLabel	"acetophenone carboxylase"
RHEA:28647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetophenone carboxylase"
REACT:R-RNO-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Rattus norvegicus)
REACT:R-BTA-9658445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Bos taurus)
REACT:R-MMU-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Mus musculus)
RHEA:35152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) => (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH
REACT:R-DDI-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Dictyostelium discoideum)
RHEA:34405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone => 9-cis-10'-apo-beta-carotenal + 2 O2
RHEA:19279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl) => ATP + L-pyrrolysine + tRNA(Pyl)
REACT:R-SPO-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Schizosaccharomyces pombe)
RHEA:52665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain (3S)-3-hydroxyacyl-CoA => a short-chain (2E)-enoyl-CoA + H2O
RHEA:14028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + sepiapterin <=> NH4(+) + xanthopterin-B2
REACT:R-CFA-5638332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)
RHEA:53058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine
REACT:R-DRE-140216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PMAIP1 (NOXA) to mitochondria (Danio rerio)
REACT:R-SCE-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Saccharomyces cerevisiae)
RHEA:55614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+) => an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O
REACT:R-CFA-8873946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD3 deubiquitinates PTEN (Canis familiaris)
RHEA:67057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chermesin D + S-adenosyl-L-methionine => chermesin D methyl ester + S-adenosyl-L-homocysteine
REACT:R-RNO-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Rattus norvegicus)
REACT:R-CFA-2046265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the keratan chain (Canis familiaris)
REACT:R-DME-450741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VANG, IN, FY, and FRTZ colocalise at the plasma membrane (Drosophila melanogaster)
REACT:R-RNO-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Rattus norvegicus)
REACT:R-SPO-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Schizosaccharomyces pombe)
REACT:R-DRE-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)
RHEA:11887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + cortisol <=> adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)
RHEA:68949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esculetin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + scopoletin
RHEA:12327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> L-asparagine + N-acetyl-D-glucosamine
RHEA:33763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-2-enoyl-CoA reductase (NADPH)"
RHEA:33763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+)
RHEA:33763	skos:prefLabel	"trans-2-enoyl-CoA reductase (NADPH)"
REACT:R-BTA-110250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenoadenine by MPG glycosylase (Bos taurus)
REACT:R-DDI-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Dictyostelium discoideum)
REACT:R-CFA-73729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of SL1 (Canis familiaris)
REACT:R-DME-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Drosophila melanogaster)
GO:0103105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-6-methylthiohexanoate aminotransferase activity
REACT:R-BTA-111289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)
RHEA:28628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + solavetivol => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone
REACT:R-RNO-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Rattus norvegicus)
REACT:R-GGA-5620921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Gallus gallus)
REACT:R-MMU-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Mus musculus)
REACT:R-RNO-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Rattus norvegicus)
GO:0060089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular transducer activity
REACT:R-BTA-420274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIP receptor binds gastric inhibitory peptide (Bos taurus)
RHEA:48423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) <=> CMP + ganglioside GM1 (d18:1(4E)) + H(+)
RHEA:10745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => 3,4-dihydroxybenzoate + CO2 + NADH
REACT:R-HSA-391865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)
RHEA:53117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11beta-hydroxysteroid + NAD(+) => an 11-oxosteroid + H(+) + NADH
RHEA:39914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-methylphenylalanine + 2-oxoglutarate <=> (3S)-2-oxo-3-phenylbutanoate + L-glutamate
RHEA:46068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-nonenoyl-CoA = (2E)-nonenoyl-CoA
GO:0008120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Homo sapiens)
GO:0008120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:N-acylsphingosine D-glucosyltransferase activity
GO:0008120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ceramide:UDPGlc glucosyltransferase activity
GO:0008120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide glucosyltransferase activity
GO:0008120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-ceramide glucosyltransferase activity
GO:0008120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-ceramide glucosyltransferase activity
GO:0008120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:ceramide glucosyltransferase activity
GO:0008120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosylceramide synthase activity
GO:0008120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ceramide:UDP-glucose glucosyltransferase activity
GO:0008120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:N-acylsphingosine D-glucosyltransferase activity
REACT:R-MMU-8874470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Mus musculus)
RHEA:25018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate
REACT:R-BTA-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Bos taurus)
REACT:R-DRE-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Danio rerio)
REACT:R-MMU-8964274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12) binds BTK (Mus musculus)
REACT:R-DME-399936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of integrin activation by sequestering PIP5KIgamma (Drosophila melanogaster)
REACT:R-HSA-170846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 recruits TGFBR1 (Homo sapiens)
REACT:R-SPO-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Schizosaccharomyces pombe)
RHEA:50828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate
REACT:R-MMU-8952807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dissociates after IL12:IL12R interaction (Mus musculus)
RHEA:46079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-eicosenoyl-CoA + H(+) + NADH <=> eicosanoyl-CoA + NAD(+)
RHEA:63222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine
REACT:R-CFA-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Canis familiaris)
REACT:R-MMU-1454822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP1,2,8,13, PRSS2 (Mus musculus)
RHEA:43726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase] => (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:43447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-ditetradecanoyl-sn-glycerol + ATP <=> 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-MMU-9700120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTN and MDK bind to PTPRZ (Mus musculus)
REACT:R-DME-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Drosophila melanogaster)
REACT:R-CFA-1299359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TALK (Canis familiaris)
REACT:R-MMU-5654397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS2 (Mus musculus)
REACT:R-CFA-5625426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde IFT (Canis familiaris)
REACT:R-XTR-5693574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Xenopus tropicalis)
REACT:R-DRE-8878220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the NOTCH1 coactivator complex (Danio rerio)
RHEA:17105	skos:prefLabel	"malonyl-[acyl-carrier protein] O-methyltransferase"
RHEA:17105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine
RHEA:17105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malonyl-[acyl-carrier protein] O-methyltransferase"
REACT:R-SSC-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Sus scrofa)
RHEA:38645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O
REACT:R-RNO-4755536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates RELA with SUMO3 (Rattus norvegicus)
RHEA:32421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2R,4R)-neoisodihydrocarveol + NAD(+)
RHEA:42853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Danio rerio)
REACT:R-CFA-2129362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin microfibril assembly (Canis familiaris)
REACT:R-DRE-8931981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ESR1 (Danio rerio)
REACT:R-DRE-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Danio rerio)
RHEA:25015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tryptophan
REACT:R-DRE-5661230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds arsenic (Danio rerio)
REACT:R-XTR-8942302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP13 cleaves OPTC (Xenopus tropicalis)
RHEA:49106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester => Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine
REACT:R-DRE-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Danio rerio)
RHEA:25607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3-methylsulfanyl)propylmalate + CoA + H(+) => 2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O
GO:0001050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T3/T7 type RNA polymerase binding
GO:0001050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T3-type RNA polymerase binding
GO:0001050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SP6-type RNA polymerase binding
GO:0001050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T7-type RNA polymerase binding
GO:0001050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-subunit type RNA polymerase binding
REACT:R-DME-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Drosophila melanogaster)
RHEA:55583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine <=> AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate
RHEA:30423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate
RHEA:30423	skos:prefLabel	"(+)-delta-selinene synthase"
RHEA:30423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-delta-selinene synthase"
EC:4.2.2.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xanthan lyase"
EC:4.2.2.12	skos:prefLabel	"xanthan lyase"
REACT:R-PFA-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)
REACT:R-SSC-400682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Rac1 interacts with Plexin-B1:Sema4D (Sus scrofa)
REACT:R-CFA-4754187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Canis familiaris)
REACT:R-SSC-2396561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GADS:SLP-76 to p-5Y-LAT (Sus scrofa)
RHEA:60985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoate + NAD(+) => 16-oxohexadecanoate + H(+) + NADH
RHEA:65854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-hydroxy-3-oxo steroid => a 3-oxo-Delta(1)-steroid + H2O
REACT:R-SSC-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Sus scrofa)
REACT:R-MMU-508369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Mus musculus)
REACT:R-SSC-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Sus scrofa)
RHEA:23535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholate + CoA <=> AMP + choloyl-CoA + diphosphate
REACT:R-DRE-5432814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR2:TLR1 (Danio rerio)
REACT:R-MMU-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Mus musculus)
RHEA:47485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
REACT:R-MMU-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)
EC:7.6.-.-	skos:prefLabel	"Catalysing the translocation of other compounds"
EC:7.6.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Catalysing the translocation of other compounds"
REACT:R-XTR-1981128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Xenopus tropicalis)
RHEA:47554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + glycine => glycodeoxycholate + H2O
REACT:R-HSA-9027373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma (Homo sapiens)
RHEA:37657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA
REACT:R-RNO-2534359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CatSper Channel Mediated Calcium Transport (Rattus norvegicus)
REACT:R-BTA-8874206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L3 (Bos taurus)
REACT:R-RNO-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Rattus norvegicus)
REACT:R-MMU-5634100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 dissociates from RXRA:PPARD:atRA (Mus musculus)
REACT:R-DRE-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Danio rerio)
RHEA:12570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol + H2O + NAD(+) => 4-nitrophenol + H(+) + NADH + O2
GO:0046876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	violet-sensitive opsin
GO:0046876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	blue-sensitive opsin
GO:0046876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-didehydroretinal binding
GO:0046876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	short-wave-sensitive opsin
GO:0046876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UV-sensitive opsin
GO:0046876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	green-sensitive opsin
GO:0046876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	long-wave-sensitive opsin
GO:0046876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	opsin
GO:0046876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	red-sensitive opsin
REACT:R-HSA-6802927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)
RHEA:17904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthotoxol <=> H(+) + S-adenosyl-L-homocysteine + xanthotoxin
EC:3.4.11.10	skos:prefLabel	"bacterial leucyl aminopeptidase"
EC:3.4.11.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacterial leucyl aminopeptidase"
EC:3.4.11.10	skos:altLabel	"Aeromonas proteolytica aminopeptidase"
RHEA:20596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamine <=> acetate + D-glucosamine
GO:0061995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent protein-DNA complex displacement activity
GO:0061995	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP-dependent protein-nucleic acid complex displacement activity
GO:0102094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-demethylmenaquinone + S-adenosyl-L-methionine = a menaquinone + H(+) + S-adenosyl-L-homocysteine
GO:0102094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity
REACT:R-GGA-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Gallus gallus)
RHEA:35488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1855179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Homo sapiens)
REACT:R-DME-8939201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR dimerizes (Drosophila melanogaster)
RHEA:46338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxy-3-oxochol-4-en-22-oyl-CoA => 3-oxochola-4,17-dien-22-oyl-CoA + H2O
REACT:R-DRE-6783670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1 binds CLCF1 (Danio rerio)
REACT:R-MMU-176588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + PAPS => lithocholate sulfate + PAP (Mus musculus)
RHEA:39118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH
RHEA:18184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + glyoxylate + H2O <=> (S)-malate + CoA + H(+)
REACT:R-PFA-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Plasmodium falciparum)
REACT:R-RNO-975103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Rattus norvegicus)
REACT:R-CFA-9648983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Canis familiaris)
RHEA:13249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH
RHEA:13249	skos:prefLabel	"2-(R)-hydroxypropyl-CoM dehydrogenase"
RHEA:13249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-(R)-hydroxypropyl-CoM dehydrogenase"
RHEA:13249	skos:altLabel	"2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase"
RHEA:37651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
GO:0043888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGGGPS
GO:0043888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGGGP synthase activity
GO:0043888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dGGGPS
GO:0043888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity
GO:0043888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UbiA
RHEA:48281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 + UDP-alpha-D-galactose => ganglioside GM1 + H(+) + UDP
RHEA:20557	skos:prefLabel	"urease"
RHEA:20557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + urea = CO2 + 2 NH4(+)
RHEA:20557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"urease"
REACT:R-XTR-212007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1 4-hydroxylate atRA (Xenopus tropicalis)
RHEA:31703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol
RHEA:56276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-proline = 3'-L-prolyl-AMP + diphosphate
GO:0033456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine tRNA
GO:0033456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCG codon-amino acid adaptor activity
RHEA:32433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-menthone + H(+) + NADPH + O2
REACT:R-BTA-1454822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP1,2,8,13, PRSS2 (Bos taurus)
REACT:R-DRE-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Danio rerio)
GO:0004866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endopeptidase inhibitor activity
GO:0004866	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endoproteinase inhibitor
GO:0004866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-2 macroglobulin
GO:0004866	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proteinase inhibitor
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:ferricytochrome-b5 oxidoreductase activity
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)
GO:0004128	skos:prefLabel	"cytochrome-b5 reductase"
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-ferricytochrome b5 oxidoreductase activity
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-cytochrome-b5 reductase activity
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-cytochrome b5 reductase activity
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome b5 reductase activity
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytochrome-b5 reductase"
GO:0004128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH 5alpha-reductase activity
REACT:R-HSA-5689111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 autoubiquitinates (Homo sapiens)
REACT:R-GGA-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Gallus gallus)
REACT:R-DME-9013157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the plasma membrane (Drosophila melanogaster)
REACT:R-HSA-453358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)
REACT:R-CFA-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Canis familiaris)
EC:7.4.2.1	skos:altLabel	"polar-amino-acid-transporting ATPase"
EC:7.4.2.1	skos:altLabel	"histidine permease"
EC:7.4.2.1	skos:prefLabel	"ABC-type polar-amino-acid transporter"
EC:7.4.2.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type polar-amino-acid transporter"
REACT:R-RNO-1678923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR folding by chaperones GP96 and CNPY3 (Rattus norvegicus)
REACT:R-BTA-6785762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL13RA1 binds TYK2 (Bos taurus)
RHEA:26082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate
RHEA:13100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] <=> a (2E)-enoyl-[ACP] + H2O
RHEA:37387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:12113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + S-adenosyl-L-methionine => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine
EC:4.98.-.-	skos:prefLabel	"ATP-independent chelatases"
EC:4.98.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ATP-independent chelatases"
REACT:R-RNO-8874849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBRF binds CREB3 (Rattus norvegicus)
RHEA:37298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-threonine(out) <=> ADP + H(+) + L-alanyl-L-threonine(in) + phosphate
REACT:R-BTA-159729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)
RHEA:47111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + taurine <=> H2O + taurocholate
REACT:R-DME-5666088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP recruits DAIPH2-3 to endosomes (Drosophila melanogaster)
RHEA:51845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
REACT:R-BTA-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Bos taurus)
REACT:R-HSA-190245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1b binds to FGF (Homo sapiens)
GO:0102413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-methyl-deacetylisoipecoside beta-glucosidase activity
REACT:R-CEL-192331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)
REACT:R-GGA-8982163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)
RHEA:51281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-MMU-3222006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STK11 (LKB1) phosphorylates NUAK1 (Mus musculus)
REACT:R-HSA-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Homo sapiens)
REACT:R-CFA-8964284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in active Gq-BTK complex is activated (Canis familiaris)
REACT:R-SSC-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Sus scrofa)
REACT:R-CFA-5419273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of GTP and dissociation of 28S and 39S subunits (Canis familiaris)
REACT:R-HSA-73865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
REACT:R-HSA-4641205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPO:LGR binds ZNRF3 (Homo sapiens)
RHEA:29471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + H2O = D-ribose + phosphate
RHEA:33315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:29688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltoheptaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltohexaose
REACT:R-CFA-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Canis familiaris)
RHEA:45356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(11Z-eicosenoyl)-sphing-4-enine = (11Z)-eicosenoate + sphing-4-enine
REACT:R-SPO-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Schizosaccharomyces pombe)
REACT:R-DRE-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Danio rerio)
REACT:R-GGA-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Gallus gallus)
REACT:R-SSC-983696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Immunoglobulin of the BCR binds antigen (Sus scrofa)
REACT:R-PFA-9613570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Plasmodium falciparum)
RHEA:45311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin D2-ethanolamide <=> 11beta-prostaglandin F2-ethanolamide + NADP(+)
REACT:R-HSA-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Homo sapiens)
RHEA:65261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	verruculide C epoxide => 3-hydroxypentacecilide A
REACT:R-DRE-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Danio rerio)
REACT:R-SSC-6794355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 binds mGluR1a,5 (Sus scrofa)
GO:0010853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclase activator activity
REACT:R-SCE-193385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of choloyl-CoA to cholate and CoASH (Saccharomyces cerevisiae)
REACT:R-CFA-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Canis familiaris)
RHEA:72132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine(out) => agmatine(in)
RHEA:11194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O
REACT:R-CFA-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Canis familiaris)
RHEA:53380	skos:altLabel	"tRNA-dihydrouridine synthase 1"
RHEA:53380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]"
RHEA:53380	skos:prefLabel	"tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]"
RHEA:53380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(16) in tRNA + NAD(+) = H(+) + NADH + uridine(16) in tRNA
REACT:R-BTA-1028820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of VAF (virus-activated factor) complex (Bos taurus)
REACT:R-HSA-8942052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide and nitric oxide react to peroxynitrite in the phagosome (Homo sapiens)
REACT:R-GGA-532632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)
REACT:R-HSA-9634834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACHEIs bind ACHE (Homo sapiens)
GO:0032896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA 9-desaturase activity
GO:0032896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA delta9-desaturase acitivity
REACT:R-GGA-451474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bacterial Flagellin binds TLR5 homodimer (Gallus gallus)
RHEA:39638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)
REACT:R-GGA-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Gallus gallus)
REACT:R-CEL-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)
RHEA:56165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA
GO:0102752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)
REACT:R-MMU-5662608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds cadmium (Mus musculus)
REACT:R-CFA-3322016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Canis familiaris)
REACT:R-BTA-2672334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNN channels transport extracellular Na+ to cytosol (Bos taurus)
REACT:R-MMU-448678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTSG cleaves CASP1(1-404) (Mus musculus)
RHEA:26464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine => 6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine
REACT:R-RNO-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Rattus norvegicus)
RHEA:43841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Xenopus tropicalis)
REACT:R-DRE-445448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHIP binds Hedgehog (Danio rerio)
RHEA:38189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Sus scrofa)
RHEA:44649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)
REACT:R-RNO-5649673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyA from damaged DNA (Rattus norvegicus)
REACT:R-SSC-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)
RHEA:19265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH
RHEA:19265	skos:prefLabel	"carnitine 3-dehydrogenase"
RHEA:19265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnitine 3-dehydrogenase"
REACT:R-CFA-8955289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
RHEA:29512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-valencene + diphosphate
RHEA:22364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH
REACT:R-RNO-5578883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Rattus norvegicus)
REACT:R-SSC-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Sus scrofa)
RHEA:22059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + NAD(+) <=> H(+) + hexadecanal + NADH
REACT:R-BTA-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Bos taurus)
REACT:R-RNO-9706340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y-GRB10 binds PIK3R1 (Rattus norvegicus)
RHEA:66084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + oxaloacetate = H2O + kynurenate + L-aspartate
RHEA:13672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) <=> 3-hydroxy-2-methylpyridine-5-carboxylate + CO2
REACT:R-DME-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Drosophila melanogaster)
RHEA:38197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-SPO-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Schizosaccharomyces pombe)
REACT:R-HSA-3700992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates MDM2 transcription (Homo sapiens)
EC:3.4.24.61	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nardilysin"
EC:3.4.24.61	skos:altLabel	"NRD convertase"
EC:3.4.24.61	skos:altLabel	"N-arginine dibasic convertase"
EC:3.4.24.61	skos:prefLabel	"nardilysin"
REACT:R-GGA-174786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Gallus gallus)
REACT:R-RNO-419003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Nectins with Afadin (Rattus norvegicus)
REACT:R-XTR-982768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GH:GHR:JAK2 complex undergoes a conformational change (Xenopus tropicalis)
RHEA:54283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate
REACT:R-SPO-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Schizosaccharomyces pombe)
REACT:R-HSA-2395872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)
RHEA:57593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9697086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rifampicin binds Mtb RNAP (Homo sapiens)
RHEA:48223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA <=> (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:33574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + methanol <=> AH2 + formaldehyde
REACT:R-BTA-9639287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2 binds L-leucine and dissociates from GATOR2 (Bos taurus)
RHEA:68338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantetheine sulfonate + phosphate => (R)-4'-phosphopantetheine sulfonate + H2O
REACT:R-HSA-8938938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and ELF1 bind the IL3 gene promoter (Homo sapiens)
RHEA:11837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
REACT:R-RNO-2473584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP15 (Rattus norvegicus)
RHEA:59523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoyl-CoA + hydrogencarbonate <=> (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate
RHEA:41826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexanoyl-[ACP] + NADP(+) => 3-oxohexanoyl-[ACP] + H(+) + NADPH
REACT:R-HSA-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Homo sapiens)
RHEA:30913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + sphing-4-enine-phosphocholine => a sphingomyelin + H2O
REACT:R-MMU-8983059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Mus musculus)
GO:0070205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity
GO:0070205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SHCHC synthase activity
GO:0070205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity
GO:0070205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MenH
GO:0070205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
GO:0070205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	YfbB
REACT:R-DRE-2395879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)
GO:0034812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxybenzo(a)pyrene dioxygenase activity
REACT:R-HSA-8983878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Homo sapiens)
REACT:R-BTA-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Bos taurus)
REACT:R-DRE-1253343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds ERBB4s80 (Danio rerio)
REACT:R-DME-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Drosophila melanogaster)
REACT:R-CEL-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Caenorhabditis elegans)
RHEA:47898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH => 6-sulfo-D-quinovose + NAD(+)
REACT:R-BTA-5419281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRRF binds 55S ribosome:mRNA:tRNA (Bos taurus)
REACT:R-DRE-6797913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARDH:FAD oxidatively demethylates SARC to Gly (Danio rerio)
GO:0005138	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-6 receptor ligand
GO:0005138	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-6
GO:0005138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-6 receptor binding
REACT:R-MMU-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Mus musculus)
REACT:R-BTA-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Bos taurus)
RHEA:56090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + globoside DSGG + H(+) => CMP-N-acetyl-beta-neuraminate + globoside MSGG
RHEA:17410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-coclaurine + S-adenosyl-L-methionine => (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-443782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHL1 interacts with contactin-6 (Homo sapiens)
REACT:R-MMU-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)
REACT:R-CEL-5339535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTPD1 transports C1P from plasma membrane to Golgi membrane (Caenorhabditis elegans)
GO:0045152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	antisigma factor binding
GO:0045152	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	antisigma factor antagonist activity
RHEA:68112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propanamide = NH4(+) + propanoate
REACT:R-HSA-5244500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botE:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
RHEA:10095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 3'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate
GO:0004019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP--aspartate ligase activity
GO:0004019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate synthase activity
GO:0004019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylosuccinate synthetase activity
GO:0004019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinoadenylic kinosynthetase activity
GO:0004019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP:L-aspartate ligase (GDP-forming)
GO:0004019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succino-AMP synthetase activity
REACT:R-HSA-1482679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2G2A (Homo sapiens)
REACT:R-MMU-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Mus musculus)
RHEA:41512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine + NAD(+)
REACT:R-DME-3204311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOX1 oxidises PXL to PDXate (Drosophila melanogaster)
RHEA:16016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + tRNA(Gly) <=> AMP + diphosphate + glycyl-tRNA(Gly)
REACT:R-MMU-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Mus musculus)
GO:0120233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenylated FMNH2 binding
GO:0120233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenyl-FMNH2 binding
REACT:R-DRE-193719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Danio rerio)
REACT:R-SSC-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Sus scrofa)
RHEA:30749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + FADH2 => FAD + H(+) + hexadecanoyl-CoA
REACT:R-DDI-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Dictyostelium discoideum)
GO:0140098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalytic activity, acting on RNA
RHEA:43049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagatose => keto-D-sorbose
RHEA:22374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H(+) + H2O2 + nitrite => H2O + O2 + propionate 3-nitronate
REACT:R-SSC-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Sus scrofa)
GO:0103036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH:menaquinone oxidoreductase activity
REACT:R-DME-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Drosophila melanogaster)
REACT:R-SSC-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Sus scrofa)
RHEA:48140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite
RHEA:48140	skos:altLabel	"PaO"
RHEA:48140	skos:altLabel	"PAO"
RHEA:48140	skos:prefLabel	"pheophorbide a oxygenase"
RHEA:48140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pheophorbide a oxygenase"
RHEA:48140	skos:altLabel	"pheide a oxygenase"
RHEA:48140	skos:altLabel	"pheide a monooxygenase"
RHEA:23966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + 2 H(+) + NADPH => (E)-coniferaldehyde + H2O + NADP(+)
RHEA:14234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA
RHEA:30044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + L-aspartate => iminosuccinate + succinate
RHEA:31105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate + H(+) + NADPH => 7,8-dihydrofolate + NADP(+)
RHEA:48374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O
RHEA:72140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(in) + H(+)(out) => estrone 3-sulfate(out) + H(+)(in)
REACT:R-CFA-1475025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Canis familiaris)
RHEA:15180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine
RHEA:66495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
RHEA:24217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesal + H2O + NAD(+) => (2E,6E)-farnesoate + 2 H(+) + NADH
RHEA:58742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+) + psi-UMP => H2O + psi-UTP
REACT:R-DRE-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Danio rerio)
REACT:R-DRE-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Danio rerio)
REACT:R-GGA-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Gallus gallus)
REACT:R-RNO-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Rattus norvegicus)
REACT:R-BTA-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Bos taurus)
EC:4.3.2.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"purine imidazole-ring cyclase"
EC:4.3.2.4	skos:prefLabel	"purine imidazole-ring cyclase"
REACT:R-HSA-9683764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike trimer translocates to ERGIC (Homo sapiens)
REACT:R-RNO-5695964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD14B hydrolyses PNPB (Rattus norvegicus)
REACT:R-HSA-5362437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are bound by lectins (Homo sapiens)
REACT:R-GGA-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Gallus gallus)
RHEA:55970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine => (+)-kolavelool + S-adenosyl-L-methionine
RHEA:14291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + omega-dicarboxyl-CoA => a dicarboxylate + ATP + CoA
RHEA:28789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(phosphooxy)-L-threonine + ADP + H(+) => 4-hydroxy-L-threonine + ATP
GO:0033957	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity
GO:0033957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lambda-carrageenase activity
RHEA:61121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Xenopus tropicalis)
RHEA:30233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesal + H2O2 + L-cysteine => H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine
REACT:R-BTA-9727607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ binds sacubitrilat (Bos taurus)
REACT:R-BTA-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Bos taurus)
RHEA:48266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]
REACT:R-CFA-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Canis familiaris)
REACT:R-RNO-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Rattus norvegicus)
REACT:R-SSC-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Sus scrofa)
REACT:R-HSA-9699574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO3-dependent BCL2L11 gene expression (Homo sapiens)
RHEA:67711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate
RHEA:62288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate = (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate
RHEA:54972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]
REACT:R-DRE-205321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of KIT and sSCF (Danio rerio)
RHEA:24622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + octanal => NAD(+) + octan-1-ol
RHEA:51419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH
REACT:R-XTR-2395992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,4S-IRF3 is dimerized (Xenopus tropicalis)
REACT:R-XTR-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Xenopus tropicalis)
REACT:R-XTR-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Xenopus tropicalis)
RHEA:53397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)
REACT:R-GGA-8875659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Gallus gallus)
REACT:R-PFA-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)
RHEA:22022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + molybdate(in) + phosphate => ATP + H2O + molybdate(out)
RHEA:37998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-nonaprenyl diphosphate + H(+) + homogentisate <=> 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate
REACT:R-HSA-5694563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD10 hydrolyses MPAG (Homo sapiens)
GO:0050417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-asparagine/L-glutamine amidohydrolase activity
GO:0050417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine(L-asparagine) amidohydrolase activity
GO:0050417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ASNase/L-GLNase activity
GO:0050417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaminase-(asparagin-)ase activity
GO:0050417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminase-asparaginase activity
GO:0050417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamin-(asparagin-)ase activity
GO:0019210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinase inhibitor activity
REACT:R-SSC-8937113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)
RHEA:59739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + tetradecanoyl-CoA <=> CoA + S-tetradecanoyl-L-cysteinyl-[protein]
RHEA:67173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] => formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite
REACT:R-DDI-3697894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN2 (Dictyostelium discoideum)
RHEA:27894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-CMP + H2O = cytidine + phosphate
REACT:R-HSA-1678927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC93B1 delivers endosomal full-length TLRs to endolysosome (Homo sapiens)
REACT:R-XTR-264976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Xenopus tropicalis)
RHEA:49579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + GTP + S-adenosyl-L-methionine <=> (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine
RHEA:65427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + NAD(+)(out) <=> AMP(out) + NAD(+)(in)
GO:0047285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol-3-O-glycoside xylosyltransferase activity
GO:0047285	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity
REACT:R-RNO-8948230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P3HB binds 4-Hyp-collagen propeptides (Rattus norvegicus)
REACT:R-BTA-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Bos taurus)
REACT:R-DRE-9618021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXG1 binds FOXO:SMAD complexes (Danio rerio)
REACT:R-MMU-5432849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds TLR4:LY96 (Mus musculus)
REACT:R-MMU-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Mus musculus)
REACT:R-SSC-749454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gi complex dissociates (Sus scrofa)
RHEA:52388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-threonate 4-kinase"
RHEA:52388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-threonate = 4-O-phospho-D-threonate + ADP + H(+)
RHEA:52388	skos:prefLabel	"D-threonate 4-kinase"
GO:0046409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-coumarate 3-hydroxylase activity
GO:0046409	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP98A3
RHEA:53103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Xenopus tropicalis)
REACT:R-HSA-9017921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPRM1 gene expression is repressed by MECP2 (Homo sapiens)
REACT:R-HSA-6782311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs (Homo sapiens)
REACT:R-RNO-212252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Rattus norvegicus)
REACT:R-DME-3928654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin internalises EPH:EFN complexes (Drosophila melanogaster)
REACT:R-XTR-8855617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Xenopus tropicalis)
REACT:R-DRE-70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Danio rerio)
RHEA:17799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose
REACT:R-RNO-265645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Influx through Voltage-gated Calcium Channels (Rattus norvegicus)
RHEA:14656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 3',5'-cyclic phosphate + H2O <=> a nucleoside 5'-phosphate + H(+)
REACT:R-DME-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Drosophila melanogaster)
REACT:R-HSA-2454081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5 oxidises 11cROL to 11cRAL (Homo sapiens)
REACT:R-BTA-8983983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Bos taurus)
RHEA:71291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) = (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)
RHEA:71965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate(in) + 3 Na(+)(in) => (R)-2-hydroxyglutarate(out) + 3 Na(+)(out)
REACT:R-XTR-3249392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Xenopus tropicalis)
REACT:R-DRE-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Danio rerio)
RHEA:61191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP
REACT:R-XTR-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Xenopus tropicalis)
RHEA:53602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O
REACT:R-DRE-139908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DLC2 by MAPK8 (Danio rerio)
RHEA:56087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-O-phosphocholine-L-serine + H2O <=> [Rab1 protein]-L-serine + H(+) + phosphocholine
RHEA:25270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline + S-adenosyl-L-methionine => (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-140599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Rattus norvegicus)
RHEA:63735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan O-beta-D-glucuronoside
REACT:R-HSA-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Homo sapiens)
REACT:R-SCE-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Saccharomyces cerevisiae)
REACT:R-BTA-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Bos taurus)
REACT:R-RNO-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Rattus norvegicus)
RHEA:35590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + H2O <=> phosphate + riboflavin
REACT:R-MMU-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Mus musculus)
RHEA:64205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-SSC-3858495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits GTP-bound RHOA (Sus scrofa)
RHEA:61628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanal = 1-piperideine + H2O
REACT:R-CFA-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
REACT:R-CFA-114256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS:APAF1 binds procaspase-9 (Canis familiaris)
RHEA:32858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-DRE-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Danio rerio)
REACT:R-RNO-870538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Rattus norvegicus)
REACT:R-SSC-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Sus scrofa)
REACT:R-DRE-977371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates Factor H-boundC3b (Danio rerio)
REACT:R-SSC-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Sus scrofa)
RHEA:13771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone + H(+) + NADH => glycerol + NAD(+)
RHEA:30428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-germacrene D + diphosphate
GO:0046933	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H+-transporting ATP synthase activity
GO:0046933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen ion translocating F-type ATPase activity
GO:0046933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen ion transporting two-sector ATPase activity
GO:0046933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton-transporting ATP synthase activity, rotational mechanism
GO:0046933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen ion transporting ATP synthase activity, rotational mechanism
RHEA:33256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-7 + S-adenosyl-L-methionine => H(+) + menaquinol-7 + S-adenosyl-L-homocysteine
RHEA:51329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 => 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate
RHEA:58503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + H(+) + NADH + O2 <=> glyoxylate + H2O + NAD(+) + trimethylamine
RHEA:43953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate
GO:0046912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0046912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyltransferase, acyl groups converted into alkyl on transfer
GO:0046912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyltransferase activity, acyl groups converted into alkyl on transfer
GO:0046912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acyl groups converted into alkyl groups on transfer"
GO:0046912	skos:prefLabel	"Acyl groups converted into alkyl groups on transfer"
RHEA:69945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol => 6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:50076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Rattus norvegicus)
REACT:R-MMU-74220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Mus musculus)
RHEA:41002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine
GO:0004565	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-(1->4)-beta-D-galactanase activity
GO:0004565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-galactosidase activity
GO:0004565	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-galactoside galactohydrolase activity
GO:0004565	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrolact
GO:0004565	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-galactanase activity
GO:0004565	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-lactosidase activity
GO:0004565	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-lactosidase activity
REACT:R-XTR-1237325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A is protonated and carbamated causing release of oxygen (Xenopus tropicalis)
RHEA:16186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH
RHEA:62263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + Mn(2+)(out) <=> 2 hydrogencarbonate(in) + Mn(2+)(in)
REACT:R-MMU-8852522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 dimer:MST1R dimer binds MST1R dimer (Mus musculus)
REACT:R-DDI-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Dictyostelium discoideum)
REACT:R-HSA-9669863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Masitinib-resistant KIT mutants do not bind masitinib (Homo sapiens)
RHEA:53951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[BtrI ACP] + L-glutamate <=> ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate
REACT:R-DME-990489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-13 is a dimer (Drosophila melanogaster)
GO:0047995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenyllactate:NAD+ oxidoreductase activity
GO:0047995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyphenylpyruvate reductase activity
GO:0047995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HPRP
RHEA:20404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-lactam + H2O <=> a substituted beta-amino acid
REACT:R-DRE-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Danio rerio)
REACT:R-CEL-2485182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Caenorhabditis elegans)
REACT:R-MMU-8854897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Mus musculus)
REACT:R-RNO-192312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Rattus norvegicus)
RHEA:12925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + L-lysyl-[protein] = H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]
REACT:R-SSC-202917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 1 (Sus scrofa)
RHEA:32436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocarvone + H(+) + NADPH + O2 => 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
REACT:R-HSA-1369017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in muscle cells (Homo sapiens)
RHEA:45595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-CFA-9686980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 recruits APC/C:Cdh1 complex to SKP2 (Canis familiaris)
REACT:R-GGA-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Gallus gallus)
RHEA:28249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + ATP <=> (R)-4-phosphopantoate + ADP + H(+)
REACT:R-SSC-5323545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canonical WNT signaling through the atypical receptor RYK (Sus scrofa)
RHEA:48000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)
REACT:R-MMU-879222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP:NLRP1 binds ATP (Mus musculus)
GO:0008269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK pathway signal transduction adaptor activity
REACT:R-BTA-1482887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)
REACT:R-BTA-1299297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of THIK (Bos taurus)
REACT:R-GGA-3321883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSL acetylates histone H4 (Gallus gallus)
RHEA:35519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine
REACT:R-CFA-9706345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)
RHEA:53651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether A + diphosphate
REACT:R-CFA-2404193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1R phosphorylates SHC1 (Canis familiaris)
RHEA:33387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine = aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine
REACT:R-MMU-2454192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Allergen dependent IgE bound FCERI aggregation (Mus musculus)
REACT:R-MMU-2584246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT1-GTP hydrolyses its bound GTP to GDP (Mus musculus)
REACT:R-PFA-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)
RHEA:45226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA
RHEA:72271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(out) + oxalate(in) = formate(in) + oxalate(out)
REACT:R-XTR-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Xenopus tropicalis)
REACT:R-DRE-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Danio rerio)
RHEA:14551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopent-4-enoate + formate + H(+) => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O
RHEA:32070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxoguanine + H(+) + H2O <=> NH4(+) + urate
REACT:R-XTR-9693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds 5HT (Xenopus tropicalis)
RHEA:32422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R,4R)-neoisodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH
REACT:R-RNO-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Rattus norvegicus)
REACT:R-SSC-8964604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Sus scrofa)
RHEA:13176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + phosphonate <=> H(+) + NADH + phosphate
RHEA:36348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine => 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine
REACT:R-RNO-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Rattus norvegicus)
REACT:R-DRE-8851988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A2 binds T cell surface (Danio rerio)
GO:0033818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketoacyl-acyl carrier protein synthase III activity
GO:0033818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ketoacyl-acyl-carrier-protein synthase III activity
GO:0033818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoacyl:ACP synthase III activity
GO:0033818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl-ACP synthase III activity
GO:0033818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KAS III
GO:0033818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FabH
GO:0033818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity
GO:0033818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KASIII
GO:0033818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl-acyl carrier protein synthase III activity
GO:0033818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl (acyl carrier protein) synthase III activity
GO:0015309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloheximide:hydrogen antiporter activity
GO:0015309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloheximide:proton antiporter activity
REACT:R-SSC-5229203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates histone H2A arginine-30 (H2AR29) (Sus scrofa)
REACT:R-SSC-8878787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPI dimer hydrolyses phosphate monoesters (Sus scrofa)
RHEA:66058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan => indole-3-pyruvate + L-kynurenine
RHEA:37853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-dihydrodaunorubicin + H2O + NADP(+) => 13-deoxydaunorubicin + H(+) + NADPH + O2
REACT:R-GGA-5656158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ elongates POLI-incorporated dNMP (Gallus gallus)
REACT:R-HSA-1482629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)
RHEA:45306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-MMU-2327695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Mus musculus)
REACT:R-MMU-381518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAAP-A proteolyzes IGF:IGFBP4 (Mus musculus)
RHEA:53189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine
RHEA:61188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP
GO:0050052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene-E4 omega-hydroxylase activity
GO:0050052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene-E4 20-monooxygenase activity
GO:0050052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
GO:0050052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene-E4 w-hydroxylase activity
GO:0050052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene-E(4) omega-hydroxylase activity
GO:0102930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate geranyltransferase activity
RHEA:67680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H(+)
REACT:R-XTR-5693583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDC1 associates with gamma-H2AFX at nuclear foci (Xenopus tropicalis)
GO:0031745	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cysteinyl leukotriene receptor ligand
GO:0031745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteinyl leukotriene receptor binding
REACT:R-MMU-5689861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of XPA and release of CAK  (Mus musculus)
RHEA:22993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + CoA + NAD(+) => acetyl-CoA + CO2 + NADH
RHEA:15314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine => acetaldehyde + NH4(+)
REACT:R-GGA-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Gallus gallus)
RHEA:14368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-carbamoyl-L-aspartate <=> CO2 + L-aspartate + NH4(+)
REACT:R-GGA-434084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRAK2- TRAF6 dissociates from the activated chTLR complex  (Gallus gallus)
REACT:R-RNO-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Rattus norvegicus)
GO:0106327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
REACT:R-XTR-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Xenopus tropicalis)
RHEA:25255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate => ATP + N-acetyl-D-mannosamine
REACT:R-DME-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Drosophila melanogaster)
RHEA:67180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate
RHEA:30502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-valine <=> (E)-2-methylpropanal oxime + CO2 + H2O
RHEA:32366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate
GO:0005019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	betaPDGF receptor activity
GO:0005019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	platelet-derived growth factor beta-receptor activity
GO:0005019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF beta-receptor activity
GO:0031878	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 somatostatin receptor ligand
GO:0031878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 somatostatin receptor binding
REACT:R-RNO-199046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligands bind L-selectin (Rattus norvegicus)
REACT:R-XTR-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Xenopus tropicalis)
RHEA:31445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-sedoheptulose 1,7-bisphosphate + H(+) => ATP + D-sedoheptulose 7-phosphate
REACT:R-GGA-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Gallus gallus)
RHEA:66960	skos:prefLabel	"GDP-Man:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und beta-1,4-mannosyltransferase"
RHEA:66960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-Man:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und beta-1,4-mannosyltransferase"
RHEA:66960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
REACT:R-DRE-201717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK2-mediated phosphorylation of DVL (Danio rerio)
RHEA:60636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(dodecanoyl)-sphing-4-enine-1-phosphocholine = choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate
RHEA:13744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-tryptophan <=> indole-3-pyruvate + L-phenylalanine
REACT:R-MMU-5637686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Mus musculus)
RHEA:48786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate => D-erythrulose 4-phosphate
REACT:R-BTA-1296037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with large conductance (Bos taurus)
REACT:R-BTA-6804441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF34 or RFFL ubiquitinates phosphorylated TP53 (Bos taurus)
REACT:R-DME-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
REACT:R-SSC-9609310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β-blockers bind ADRB1,2,3 (Sus scrofa)
RHEA:46198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]
RHEA:39882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol
REACT:R-DME-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Drosophila melanogaster)
GO:0001073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription antitermination factor activity, DNA binding
GO:0001073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA binding transcription antitermination factor activity
REACT:R-HSA-201783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive catalytic PP2B is activated by the binding of calmodulin (Homo sapiens)
REACT:R-BTA-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Bos taurus)
REACT:R-XTR-211966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2D6 4-hydroxylates debrisoquine (Xenopus tropicalis)
RHEA:17916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + nitrite <=> H(+) + NADH + nitrate
REACT:R-CFA-1605736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Canis familiaris)
GO:2001068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinoxylan binding
REACT:R-DRE-9604487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7:p-IRF7 translocates to the nucleus (Danio rerio)
GO:0008420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II carboxy-terminal domain phosphatase activity
GO:0008420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTD phosphatase activity
GO:0008420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II CTD heptapeptide repeat phosphatase activity
EC:2.1.1.137	skos:prefLabel	"arsenite methyltransferase"
EC:2.1.1.137	skos:altLabel	"methylarsonite methyltransferase"
EC:2.1.1.137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arsenite methyltransferase"
RHEA:23452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + ATP = ADP + dAMP + H(+)
RHEA:64108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
REACT:R-SSC-8850831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates KLK8 (Sus scrofa)
REACT:R-CEL-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Caenorhabditis elegans)
RHEA:39397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH
REACT:R-SSC-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-XTR-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Xenopus tropicalis)
RHEA:43986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+) => (2E,6E)-farnesol + H(+) + NADPH + O2
RHEA:57439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guaethol + O2 + reduced [NADH--hemoprotein reductase] <=> acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
RHEA:62032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O = a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)
REACT:R-MMU-109538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Mus musculus)
REACT:R-CFA-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Canis familiaris)
RHEA:45120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-ipsdienol + NAD(+) = H(+) + ipsdienone + NADH
REACT:R-SSC-8848993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated KHDRBS1 translocates to the cytosol (Sus scrofa)
REACT:R-HSA-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Homo sapiens)
REACT:R-GGA-169719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted CD14 binds LPS (Gallus gallus)
REACT:R-MMU-5685994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)
REACT:R-HSA-5653756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM25 binds monoUb:164-PCNA (Homo sapiens)
RHEA:13956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-aminoacyl-tRNA + H2O <=> a D-alpha-amino acid + a tRNA + H(+)
REACT:R-CFA-4420140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Canis familiaris)
RHEA:45493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]
REACT:R-RNO-73758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Rattus norvegicus)
RHEA:31109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-hydroxyphenyl)acetate + CO2 => 3-phenylpyruvate + O2
REACT:R-SSC-8849638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the SPINK5:KLK5 complex at low pH (Sus scrofa)
RHEA:66767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + folate(in) + H2O <=> ADP + folate(out) + H(+) + phosphate
RHEA:28089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 + Reactive Blue 5 <=> 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate
RHEA:56853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reumycin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toxoflavin
REACT:R-GGA-5682967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 binds DNA DSBs (Gallus gallus)
REACT:R-HSA-6785986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
REACT:R-RNO-4084976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANS converts ManNAc-6-P to Neu5Ac-9-P (Rattus norvegicus)
RHEA:56921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + ATP + H(+) => a medium-chain fatty acyl-AMP + diphosphate
RHEA:29926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)
RHEA:38627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
RHEA:20625	skos:altLabel	"cytochrome hydrogenase"
RHEA:20625	skos:altLabel	"H2:ferricytochrome c3 oxidoreductase"
RHEA:20625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytochrome-c3 hydrogenase"
RHEA:20625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c3] + H2 = 2 Fe(II)-[cytochrome c3] + 2 H(+)
RHEA:20625	skos:prefLabel	"cytochrome-c3 hydrogenase"
RHEA:20625	skos:altLabel	"cytochrome c3 reductase"
GO:0031785	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1A melatonin receptor ligand
GO:0031785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1A melatonin receptor binding
RHEA:10463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin A1 <=> prostaglandin C1
REACT:R-CEL-9020273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Caenorhabditis elegans)
REACT:R-XTR-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Xenopus tropicalis)
REACT:R-RNO-6809707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTMR2 (Rattus norvegicus)
RHEA:51919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-butenoate + H2O <=> 2-oxobutanoate + NH4(+)
RHEA:65944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + CTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine
RHEA:13600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-diguanidinobutane + H2O <=> agmatine + urea
REACT:R-MMU-2032775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD1 (Mus musculus)
RHEA:15483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + L-serine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O
REACT:R-SSC-1632843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1 binds DYNLL1,DYNLL2 (Sus scrofa)
RHEA:13825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH
REACT:R-RNO-174367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCL ligates L-Glu to L-Cys (Rattus norvegicus)
GO:0098695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
GO:0098695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels
REACT:R-CFA-688985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63 polyubiquitinated RIP2 associates with the TAK1 complex (Canis familiaris)
REACT:R-HSA-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
REACT:R-SSC-8934735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 arginine-methylates RUNX1 (Sus scrofa)
REACT:R-DME-8849881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM2 associate with AMPA and NMDA receptors (Drosophila melanogaster)
RHEA:57723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 4 H(+)(in) + H2O <=> ADP + 5 H(+)(out) + phosphate
REACT:R-DDI-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Dictyostelium discoideum)
REACT:R-MMU-1112703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 is phosphorylated (Mus musculus)
GO:0033447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine tRNA
GO:0033447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGA codon-amino acid adaptor activity
REACT:R-MMU-216727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Mus musculus)
REACT:R-RNO-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Rattus norvegicus)
REACT:R-HSA-9667965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds PP2A (Homo sapiens)
RHEA:22123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + GTP + succinate <=> GDP + phosphate + succinyl-CoA
RHEA:43627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomalonate semialdehyde + H(+) <=> aminoacetaldehyde + CO2
REACT:R-DRE-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Danio rerio)
REACT:R-HSA-5649801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Homo sapiens)
REACT:R-DRE-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Danio rerio)
REACT:R-RNO-69144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 (Rattus norvegicus)
RHEA:61335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + indoxyl sulfate(in) <=> ADP + H(+) + indoxyl sulfate(out) + phosphate
REACT:R-SSC-2294600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates condensin II subunit NCAPD3 (Sus scrofa)
REACT:R-MMU-5649854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to oxidatively damaged AP site (Mus musculus)
RHEA:71733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + tartrate(out) => citrate(out) + tartrate(in)
RHEA:62820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:39979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pavine N-methyltransferase"
RHEA:39979	skos:prefLabel	"pavine N-methyltransferase"
RHEA:39979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+-)-pavine + S-adenosyl-L-methionine = H(+) + N-methylpavine + S-adenosyl-L-homocysteine
RHEA:39979	skos:altLabel	"PavNMT"
REACT:R-CFA-196417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of desmosterol to cholesterol (Canis familiaris)
REACT:R-GGA-3240295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Gallus gallus)
REACT:R-GGA-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Gallus gallus)
REACT:R-GGA-349404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Gallus gallus)
RHEA:20935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythrulose 1-phosphate <=> dihydroxyacetone phosphate + formaldehyde
GO:0070569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridyl transferase activity
GO:0070569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridylyltransferase activity
GO:0070569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridyltransferase activity
REACT:R-CFA-2995376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Canis familiaris)
RHEA:62680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphtopyrone YWA1 = H(+) + H2O + norrubrofusarin
RHEA:61421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol => cis-cis-nepetalactol
REACT:R-HSA-9668253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperactivation of factor X by FVIIIa:FIXa R384L (Homo sapiens)
RHEA:50633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O
RHEA:48265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate
RHEA:53405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-CFA-6797810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAPL1 (Canis familiaris)
REACT:R-CFA-936942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Canis familiaris)
RHEA:33817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate
REACT:R-MMU-382054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binds to extracellular matrix proteins (Mus musculus)
REACT:R-MMU-2395879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
RHEA:65047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cyanobenzyl alcohol + NAD(+) <=> 4-cyanobenzaldehyde + H(+) + NADH
RHEA:41479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + zymosterol <=> CoA + zymosterol ester
RHEA:51082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0034071	skos:altLabel	"APH(2'')"
GO:0034071	skos:altLabel	"aminoglycoside (2'') kinase"
GO:0034071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminoglycoside 2''-phosphotransferase"
GO:0034071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside phosphotransferase activity
GO:0034071	skos:altLabel	"gentamicin phosphotransferase"
GO:0034071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)
GO:0034071	skos:altLabel	"gentamicin kinase"
GO:0034071	skos:prefLabel	"aminoglycoside 2''-phosphotransferase"
GO:0034071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside kinase activity
REACT:R-SSC-167429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex  binds GTP (Sus scrofa)
REACT:R-DME-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)
REACT:R-XTR-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Xenopus tropicalis)
REACT:R-CFA-2186607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
REACT:R-MMU-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Mus musculus)
RHEA:49927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-acyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acyl-(R)-carnitine(out)
REACT:R-DRE-8863494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASICs bind STOML3, (STOM) (Danio rerio)
REACT:R-SPO-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)
RHEA:31500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP
REACT:R-XTR-8852509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL-LK binds carbohydrates on target cell surface (Xenopus tropicalis)
REACT:R-MMU-8983835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Mus musculus)
RHEA:13031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamine + O2
RHEA:66472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E,10E,14E)-geranylfarnesol = 18-episcalar-17(25)-en-19-ol
RHEA:59287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O <=> D-glucose + N-octadecanoylsphing-4-enine
REACT:R-XTR-2530453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vitronectin (VTN) binds to C5b:C6:C7 (Xenopus tropicalis)
RHEA:25742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:30410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] <=> oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]
RHEA:51925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + menaquinone-9 => A + beta-dihydromenaquinone-9
REACT:R-RNO-2160884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Rattus norvegicus)
REACT:R-CFA-194310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Canis familiaris)
RHEA:22925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H(+) + H2O => dUMP + NH4(+)
REACT:R-HSA-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Homo sapiens)
REACT:R-SSC-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Sus scrofa)
REACT:R-DRE-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Danio rerio)
REACT:R-CFA-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Canis familiaris)
REACT:R-DRE-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Danio rerio)
RHEA:23035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate
GO:0098872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:0098872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
GO:0098872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
REACT:R-MMU-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Mus musculus)
REACT:R-HSA-3656254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)
REACT:R-CEL-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Caenorhabditis elegans)
REACT:R-SSC-3371353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble TNF-α binds TNFR1 (Sus scrofa)
RHEA:27275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH
RHEA:70162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate(in) + H(+)(in) <=> folate(out) + H(+)(out)
RHEA:70607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 4-ethylphenol = 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:21775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(6666) in apoB mRNA + H(+) + H2O <=> NH4(+) + uridine(6666) in apoB mRNA
RHEA:47835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a + H2O <=> ganglioside GM1 + N-acetylneuraminate
REACT:R-CFA-8950269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Canis familiaris)
REACT:R-DME-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Drosophila melanogaster)
RHEA:72405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + urate(out) => 2-oxoglutarate(out) + urate(in)
REACT:R-HSA-4641206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPOs bind LGRs (Homo sapiens)
REACT:R-HSA-190782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of connexon-containing transport vesicles from the Golgi (Homo sapiens)
GO:0140949	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K9 trimethylation
GO:0140949	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K9 trimethylation
GO:0140949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-trimethyltransferase activity (H3-K9 specific)
GO:0140949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 mono/di/trimethylase activity
GO:0140949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 trimethylase activity
GO:0140949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 trimethyltransferase activity
RHEA:16704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + NAD(+) <=> estrone + H(+) + NADH
RHEA:58394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:17383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate
REACT:R-HSA-159574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Homo sapiens)
REACT:R-MMU-6787321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DERA cleaves dR5P to GA3P and CH3CHO (Mus musculus)
RHEA:12336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxymethyloxysuccinate lyase"
RHEA:12336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxymethoxysuccinate = fumarate + glycolate
RHEA:12336	skos:prefLabel	"carboxymethyloxysuccinate lyase"
REACT:R-MMU-5654594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)
RHEA:60621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hexanoyl-sphing-4-enine-1-phosphocholine => choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate
REACT:R-GGA-8865320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX1 (Gallus gallus)
RHEA:32023	skos:prefLabel	"avermitilol synthase"
RHEA:32023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"avermitilol synthase"
RHEA:32023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate
RHEA:60070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2
REACT:R-HSA-2167917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF1 (Homo sapiens)
RHEA:25061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) + NADH + O2 <=> (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)
RHEA:33118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(in) <=> malonate(out)
GO:0031759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edg-6 sphingosine 1-phosphate receptor binding
GO:0031759	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Edg-6 sphingosine 1-phosphate receptor ligand
REACT:R-XTR-5691507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPA deacetylates NAA to acetate and L-aspartate (Xenopus tropicalis)
RHEA:48351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in RNA <=> a pseudouridine in RNA
RHEA:28684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + ubiquinone-8 => iminosuccinate + ubiquinol-8
REACT:R-HSA-5624256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)
RHEA:19253	skos:altLabel	"neutral sphingomyelinase"
RHEA:19253	skos:altLabel	"acid sphingomyelinase"
RHEA:19253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine
RHEA:19253	skos:prefLabel	"sphingomyelin phosphodiesterase"
RHEA:19253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingomyelin phosphodiesterase"
REACT:R-HSA-9717396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)
RHEA:16853	skos:prefLabel	"adenylosuccinate lyase"
RHEA:16853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylosuccinate lyase"
RHEA:16853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate
RHEA:16853	skos:altLabel	"succino AMP-lyase"
RHEA:16853	skos:altLabel	"adenylosuccinase"
RHEA:16853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate
REACT:R-CFA-5682826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM11 (Canis familiaris)
RHEA:52916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:26383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + succinate semialdehyde => 4-hydroxybutanoate + NADP(+)
REACT:R-RNO-9684068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD binds cardiac glycosides (Rattus norvegicus)
REACT:R-BTA-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Bos taurus)
RHEA:28042	skos:prefLabel	"pyruvate dehydrogenase system"
RHEA:28042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate dehydrogenase system"
RHEA:28042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + pyruvate = acetyl-CoA + CO2 + NADH
RHEA:28042	skos:altLabel	"PDH"
RHEA:28042	skos:altLabel	"pyruvate dehydrogenase complex"
RHEA:13197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + sulfite + UDP-alpha-D-glucose = H2O + UDP-alpha-D-6-sulfoquinovose
RHEA:13197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-sulfoquinovose synthase"
RHEA:13197	skos:altLabel	"sulfite:UDP-glucose sulfotransferase"
RHEA:13197	skos:prefLabel	"UDP-sulfoquinovose synthase"
REACT:R-BTA-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Bos taurus)
REACT:R-SPO-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Schizosaccharomyces pombe)
REACT:R-SSC-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Sus scrofa)
REACT:R-RNO-170153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Rattus norvegicus)
REACT:R-XTR-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Xenopus tropicalis)
REACT:R-BTA-3149563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Bos taurus)
REACT:R-RNO-977359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to membrane-associated Factor H:C3b (Rattus norvegicus)
RHEA:54242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline
RHEA:19267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnitine + H(+) + NADH => carnitine + NAD(+)
REACT:R-HSA-5662595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1E binds cadmium (Homo sapiens)
REACT:R-MMU-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Mus musculus)
RHEA:65699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine
REACT:R-DRE-352136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Danio rerio)
REACT:R-XTR-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Xenopus tropicalis)
REACT:R-RNO-1306957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)
REACT:R-HSA-9033526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5S (Homo sapiens)
REACT:R-HSA-1878002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLTs transfer Xyl to core protein (Homo sapiens)
RHEA:67577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O => [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine
REACT:R-HSA-5654597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
RHEA:35777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate + UDP-alpha-D-kanosamine => L-glutamine + UDP-3-oxo-alpha-D-glucose
REACT:R-CFA-8854182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D17 binds OPTN:RAB8A (Canis familiaris)
RHEA:42884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + ATP = (R)-3-phosphomevalonate + ADP + H(+)
RHEA:42884	skos:prefLabel	"mevalonate 3-kinase"
RHEA:42884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mevalonate 3-kinase"
REACT:R-DRE-8871227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA4 (Danio rerio)
REACT:R-CFA-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Canis familiaris)
REACT:R-MMU-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Mus musculus)
EC:2.3.2.32	skos:prefLabel	"cullin-RING-type E3 NEDD8 transferase"
EC:2.3.2.32	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cullin-RING-type E3 NEDD8 transferase"
EC:5.5.1.-	skos:prefLabel	"Intramolecular lyases"
EC:5.5.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Intramolecular lyases"
REACT:R-CFA-83791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Canis familiaris)
REACT:R-XTR-4085021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Xenopus tropicalis)
REACT:R-HSA-9632039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)
RHEA:30940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dIDP => ADP + dITP
RHEA:42965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(54/55) in tRNA => pseudouridine(54/55) in tRNA
RHEA:40575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + H2O = CoA + glutarate + H(+)
RHEA:66471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O <=> (17E)-cheilanthenediol
REACT:R-BTA-171106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex => LDLR + LDL (Bos taurus)
REACT:R-SSC-9650858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Meglitinides bind ABCC8 (Sus scrofa)
RHEA:18728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA <=> acetyl-CoA + vanillin
RHEA:44656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-XTR-8857692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA demethylases demethylate N6-methyladenosine RNA (Xenopus tropicalis)
RHEA:21237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 2 H(+) + NADPH + O2 => 2,3-dihydroxybenzoate + NADP(+) + NH4(+)
REACT:R-RNO-5675433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)
REACT:R-SPO-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Schizosaccharomyces pombe)
RHEA:32569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-camphene + diphosphate => (2E)-geranyl diphosphate
REACT:R-GGA-158145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Gallus gallus)
RHEA:56336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-isokaurene C2/C3-hydroxylase"
RHEA:56336	skos:altLabel	"CYP71Z6"
RHEA:56336	skos:prefLabel	"ent-isokaurene C2/C3-hydroxylase"
RHEA:56336	skos:altLabel	"ent-isokaurene C2-hydroxylase"
RHEA:56336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Homo sapiens)
REACT:R-GGA-5654582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates SHC1 (Gallus gallus)
REACT:R-SPO-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)
RHEA:53507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate
RHEA:19120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + 2 L-ascorbate + O2 <=> (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical
REACT:R-RNO-6801675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates NPM1 (Rattus norvegicus)
REACT:R-XTR-3209159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERF translocates to the cytosol (Xenopus tropicalis)
REACT:R-XTR-437139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT6 transports zinc into the golgi apparatus (Xenopus tropicalis)
GO:0102650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo-acetoacetyl-L-tryptophan synthetase activity
GO:0047158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity
GO:0047158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity
GO:0047158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity
GO:0047158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity
RHEA:49241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) => L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)
REACT:R-GGA-5654584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS bind to PPTN11 (Gallus gallus)
RHEA:65008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + decanoate + H(+) = decanoyl-AMP + diphosphate
RHEA:49424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + validone = ADP + H(+) + validone 7-phosphate
RHEA:58912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + iron(III) dicitrate(out) = ADP + H(+) + iron(III) dicitrate(in) + phosphate
RHEA:58912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type ferric citrate transporter"
RHEA:58912	skos:altLabel	"ferric citrate ABC transporter"
RHEA:58912	skos:prefLabel	"ABC-type ferric citrate transporter"
RHEA:58912	skos:altLabel	"ferric citrate transporting ATPase"
REACT:R-RNO-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Rattus norvegicus)
REACT:R-XTR-4167509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial BTD hydrolyses BCTN (Xenopus tropicalis)
RHEA:24945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-L-glutamate + H(+) + NADPH => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+)
RHEA:18010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]
REACT:R-DRE-4085021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Danio rerio)
RHEA:56520	skos:prefLabel	"AdoMet-dependent heme synthase"
RHEA:56520	skos:altLabel	"SAM-dependent heme synthase"
RHEA:56520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"AdoMet-dependent heme synthase"
RHEA:56520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine
REACT:R-HSA-3828025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP14 (Homo sapiens)
RHEA:55134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate => ATP + D-alanine + holo-[D-alanyl-carrier protein]
RHEA:42338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin] => [thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-XTR-9756180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Xenopus tropicalis)
RHEA:47023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite
GO:0047096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	androst-4-ene-3,17-dione hydroxylase activity
GO:0047096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androstene-3,17-dione hydroxylase activity
GO:0047096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-androstene-3,17-dione monooxygenase activity
GO:0047096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione monooxygenase activity
GO:0047096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	androstenedione monooxygenase activity
GO:0047096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	androst-4-ene-3,17-dione 17-oxidoreductase activity
GO:0047096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)
REACT:R-DRE-114684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Syntaxin-4 (Danio rerio)
REACT:R-BTA-5690023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL binds 4Fe-4S (Bos taurus)
REACT:R-RNO-196402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Rattus norvegicus)
RHEA:60943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Homo sapiens)
REACT:R-DRE-351863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active caspase-8 to the mitochondrial membrane (Danio rerio)
REACT:R-HSA-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Homo sapiens)
REACT:R-HSA-163741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Homo sapiens)
REACT:R-MMU-9020277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Mus musculus)
REACT:R-BTA-450827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Bos taurus)
REACT:R-MMU-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Mus musculus)
REACT:R-BTA-2130378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex to plasma membrane (Bos taurus)
REACT:R-GGA-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Gallus gallus)
RHEA:62039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)
RHEA:49621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythritol 1-phosphate + NADP(+) => D-erythrulose 1-phosphate + H(+) + NADPH
RHEA:64442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycylglycyl-L-proline(in) + H(+)(in) => glycylglycyl-L-proline(out) + H(+)(out)
RHEA:34258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sporulenol <=> (R)-tetraprenyl-beta-curcumene + H2O
REACT:R-GGA-5675656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA:EDAR binds EDARADD (Gallus gallus)
REACT:R-DRE-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Danio rerio)
REACT:R-MMU-373791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Mus musculus)
RHEA:14350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP
RHEA:55535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-phenylalanine + O2 <=> 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)
EC:3.4.22.42	skos:prefLabel	"cathepsin O"
EC:3.4.22.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin O"
RHEA:20143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + an S-alkyl sulfenate => an S-alkyl-L-cysteine S-oxide
REACT:R-DRE-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Danio rerio)
REACT:R-XTR-198941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCAM1 binds Integrin alpha4beta1 (Xenopus tropicalis)
GO:0050272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-chloro-L-alanine chloride-lyase (adding thioglycolate)
GO:0050272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-carboxymethylcysteine synthase activity
GO:0050272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-carboxymethyl-L-cysteine synthase activity
GO:0050272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)
REACT:R-CFA-5218905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Canis familiaris)
REACT:R-DME-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Drosophila melanogaster)
RHEA:10573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vinylacetyl-CoA => (2E)-butenoyl-CoA
REACT:R-HSA-9008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds ESR1:estrogen:TGFA gene (Homo sapiens)
REACT:R-CFA-877187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates loss of intracellular K+ (Canis familiaris)
REACT:R-BTA-5654586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS binds GRB2:SOS1 (Bos taurus)
REACT:R-MMU-114392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Mus musculus)
RHEA:55469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl acyl carrier protein synthase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fatty acid condensing enzyme activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-ketoacyl-acyl-carrier-protein synthase I
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	KASII
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-ketoacyl-ACP synthase I activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	KAS II
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl synthetase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-ketoacyl-ACP synthase II activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoacyl-acyl-carrier-protein synthase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacylsynthase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl-ACP synthetase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-ACP synthase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	3-oxoacyl-acyl carrier protein synthase I activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-[acyl-carrier protein] synthase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-malonyl acyl carrier protein-condensing enzyme activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl-acyl carrier protein synthase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl-acyl carrier protein synthetase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketoacyl-acyl carrier protein synthase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	KAS I activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl-[acyl carrier protein] synthase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	3-oxoacyl:ACP synthase I
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ketoacyl-ACP synthase activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	condensing enzyme activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO:0004315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	KASI
REACT:R-DRE-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Danio rerio)
RHEA:40916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)
RHEA:28321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scutellarein + UDP-alpha-D-glucuronate <=> scutellarin + UDP
RHEA:61570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine => an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O
RHEA:68535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (Z)-alpha-bisabolene + diphosphate
RHEA:14610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + NADP(+) => H(+) + keto-L-sorbose + NADPH
RHEA:24448	skos:prefLabel	"enterobactin C-glucosyltransferase"
RHEA:24448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP
RHEA:24448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enterobactin C-glucosyltransferase"
REACT:R-HSA-9749986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)
RHEA:64804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + S-(2-aminoethyl)-L-cysteine = CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine
REACT:R-PFA-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)
RHEA:54490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DRE-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Danio rerio)
REACT:R-MMU-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Mus musculus)
RHEA:50679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-terminal L-asparaginyl-[protein] <=> N-terminal L-aspartyl-[protein] + NH4(+)
REACT:R-DRE-2066780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Danio rerio)
RHEA:42641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-demethylmenaquinol + S-adenosyl-L-methionine => a menaquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:20004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolaldehyde + H2O + NAD(+) <=> glycolate + 2 H(+) + NADH
RHEA:10198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-succinylbenzoate + H2O => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate
REACT:R-RNO-141367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylation of tBID by NMT1 (Rattus norvegicus)
REACT:R-BTA-9661799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)
REACT:R-HSA-5655315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
RHEA:68481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxyhexadecanoate + H(+) => CO2 + H2O + pentadecanal
REACT:R-CFA-193694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 is recruited and forms a complex with TRAF6 (Canis familiaris)
RHEA:18310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-amino acid + H2O => a carboxylate + a D-alpha-amino acid
REACT:R-BTA-5607732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TAK1 autophosphorylates (Bos taurus)
REACT:R-DRE-5665767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FMNL3 binds G-actin (Danio rerio)
GO:0016811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
RHEA:14146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanidinoacetate => ADP + H(+) + phosphoguanidinoacetate
RHEA:52584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH
RHEA:62309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-malbrancheamide B + FADH2
EC:4.99.-.-	skos:prefLabel	"Other lyases"
EC:4.99.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other lyases"
RHEA:20178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine + UDP-alpha-D-glucose => 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP
REACT:R-HSA-9635912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TRIB3 in response to stress (Homo sapiens)
REACT:R-DME-9638078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)
REACT:R-SSC-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Sus scrofa)
REACT:R-XTR-9011984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A is recruited to MYC and BCL2 genes (Xenopus tropicalis)
REACT:R-MMU-177939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)
RHEA:28693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + orotate => (S)-dihydroorotate + a ubiquinone
REACT:R-CFA-9679029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds HCQ (Canis familiaris)
REACT:R-BTA-5675433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP5 dephosphorylates RAF1 S338 (Bos taurus)
REACT:R-HSA-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Homo sapiens)
REACT:R-XTR-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Xenopus tropicalis)
GO:1990931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA N(6)-methyladenosine dioxygenase activity
GO:1990931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA N(6)-methyladenine demethylase
GO:1990931	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA N6-methyladenosine dioxygenase activity
GO:1990931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA N6-methyladenosine dioxygenase activity
RHEA:21286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + H(+) + NADH => all-trans-retinol + NAD(+)
RHEA:26310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)
RHEA:55127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH <=> 5-methylhexanoyl-[ACP] + NAD(+)
REACT:R-GGA-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Gallus gallus)
RHEA:24417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4'-dihydroxyacetophenone + O2 => 4-hydroxybenzoate + formate + 2 H(+)
REACT:R-DME-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Drosophila melanogaster)
RHEA:21687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-beta-alanopine + H2O + NAD(+) <=> beta-alanine + H(+) + NADH + pyruvate
REACT:R-HSA-109470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Homo sapiens)
RHEA:71051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(out) + L-methionine(in) = L-leucine(in) + L-methionine(out)
REACT:R-GGA-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Gallus gallus)
RHEA:40058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trioctanoylglycerol + H2O <=> 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate
RHEA:60315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-MMU-8874206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L3 (Mus musculus)
RHEA:30148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + NAD(+) => FAD + 2 H(+) + NADH
GO:0003860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxyisobutyryl-CoA hydrolase"
GO:0003860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-2-methylpropanoyl-CoA hydrolase activity
GO:0003860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-isobutyryl CoA hydrolase activity
GO:0003860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)
GO:0003860	skos:prefLabel	"3-hydroxyisobutyryl-CoA hydrolase"
GO:0003860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisobutyryl-CoA hydrolase activity
GO:0003860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HIB CoA deacylase activity
RHEA:19283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen => (7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:68019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl phosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + phosphate
REACT:R-CFA-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Canis familiaris)
REACT:R-GGA-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Gallus gallus)
RHEA:33757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + hexadecanoate => H2O + N-hexadecanoyl-(4R)-hydroxysphinganine
RHEA:63863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate
RHEA:62985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanamide => hexadecanoate + NH4(+)
REACT:R-MMU-6783552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM binds LIFR:JAKs,OSMR:JAKs (Mus musculus)
RHEA:37713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA
RHEA:50356	skos:prefLabel	"4-hydroxy-6-methylpretetramide 12a-monooxygenase"
RHEA:50356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-6-methylpretetramide 12a-monooxygenase"
RHEA:50356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-methylpretetramide + NADPH + O2 = 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)
REACT:R-DME-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Drosophila melanogaster)
GO:0050369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[tyrosine 3-monooxygenase] kinase activity
GO:0050369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine 3-monooxygenase kinase activity
GO:0050369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pheochromocytoma tyrosine hydroxylase-associated kinase activity
GO:0050369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK4
GO:0050369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine 3-monooxygenase kinase (phosphorylating) activity
GO:0050369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:tyrosine-3-monoxygenase phosphotransferase activity
REACT:R-DDI-5672957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates KSR1 (Dictyostelium discoideum)
GO:0051718	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M.BsuRIb
GO:0051718	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	HpaII' methylase
GO:0051718	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	HpaII methylase
GO:0051718	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M.BsuRIa
GO:0051718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0051718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT1 methylates cytosine in hemimethylated DNA (Homo sapiens)
GO:0034737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol O-acyltransferase activity
RHEA:72116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(out) + Na(+)(out) => glycine betaine(in) + Na(+)(in)
RHEA:47200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-7alpha-dihydroxycholesterol + NAD(+) = (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH
REACT:R-DRE-3244643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds cyclic GMP-AMP (Danio rerio)
REACT:R-SCE-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Saccharomyces cerevisiae)
GO:0047784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol O-acetyltransferase activity
GO:0047784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:cortisol O-acetyltransferase activity
GO:0047784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	corticosteroid-21-O-acetyltransferase activity
GO:0047784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	corticosteroid acetyltransferase activity
GO:0047784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cortisol acetyltransferase activity
REACT:R-HSA-5683672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)
RHEA:46174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + butanoyl-CoA + diphosphate => ATP + butanoate + CoA
REACT:R-SSC-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Sus scrofa)
RHEA:39346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O
REACT:R-DME-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Drosophila melanogaster)
RHEA:38644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)
REACT:R-GGA-9021079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs:CAVs translocate to plasma membrane (Gallus gallus)
RHEA:63569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-casomorphin-7 + H2O => beta-casomorphin-6 + L-isoleucine
RHEA:60271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:54143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(49) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-388529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholecystokinin receptors bind cholecystokinin (Bos taurus)
RHEA:49612	skos:prefLabel	"2-oxoglutarate reductase"
RHEA:49612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH
RHEA:49612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoglutarate reductase"
REACT:R-HSA-912680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of JAK kinase activity by SOCS1/3 (Homo sapiens)
RHEA:17008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucuronate <=> 1-phospho-alpha-D-glucuronate + ADP + H(+)
RHEA:70100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + o-quinone methide + peniphenone D => penilactone A
REACT:R-DRE-198941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCAM1 binds Integrin alpha4beta1 (Danio rerio)
RHEA:39175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyeicosanoyl-CoA = (2E)-eicosenoyl-CoA + H2O
REACT:R-XTR-8941312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Xenopus tropicalis)
REACT:R-CFA-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Canis familiaris)
GO:0019969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-10 binding
GO:0019969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-10 binding
REACT:R-XTR-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Xenopus tropicalis)
RHEA:22422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + maleylacetate + NADH => cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+)
GO:0015541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secondary active cyanate transmembrane transporter activity
GO:0015541	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyanate porter activity
RHEA:11525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH
RHEA:33569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + AH2 => A + ethanol
RHEA:57798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcatechol + NAD(+) + nitrite => 4-nitrotoluene + NADH + O2
REACT:R-CFA-429663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-XTR-212269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Xenopus tropicalis)
REACT:R-HSA-9707353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 binds Aromatase inhibitors (Homo sapiens)
REACT:R-BTA-8957241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP73 tetramer translocates to the nucleus (Bos taurus)
RHEA:52973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]
REACT:R-CEL-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)
RHEA:24191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) <=> 1,2-dihydroxydibenzothiophene + H(+) + NADH
RHEA:42574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)
REACT:R-HSA-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Homo sapiens)
RHEA:19258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + NADP(+) => a ketone + H(+) + NADPH
REACT:R-HSA-5607724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
REACT:R-MMU-8874849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBRF binds CREB3 (Mus musculus)
REACT:R-PFA-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)
RHEA:32211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-5-oxohex-2-enedioate = (2E,4Z)-2-hydroxyhexa-2,4-dienedioate
RHEA:60448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted glutathione + H2O = glycine + S-substituted gamma-glutamyl-L-cysteine
REACT:R-GGA-3640844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 binds RibC-AXIN:TNKS complex (Gallus gallus)
RHEA:37042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O
REACT:R-HSA-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Homo sapiens)
REACT:R-DRE-1362485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GH (Danio rerio)
REACT:R-BTA-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Bos taurus)
REACT:R-DRE-9697750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8:FLIP(L) (Danio rerio)
REACT:R-BTA-73722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of UBF-1:rDNA Promoter (Bos taurus)
REACT:R-DDI-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Dictyostelium discoideum)
RHEA:34446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)
RHEA:40257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O
REACT:R-XTR-73805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Xenopus tropicalis)
RHEA:71409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:53891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + TDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + TDP
RHEA:33043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-camphor 6-exo-hydroxylase"
RHEA:33043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-camphor + H(+) + NADPH + O2 = (+)-6-exo-hydroxycamphor + H2O + NADP(+)
RHEA:33043	skos:prefLabel	"(+)-camphor 6-exo-hydroxylase"
RHEA:33043	skos:altLabel	"(+)-camphor 6-hydroxylase"
RHEA:23660	skos:altLabel	"4(5)-imidazolone-5(4)-propionic acid hydrolase"
RHEA:23660	skos:prefLabel	"imidazolonepropionase"
RHEA:23660	skos:altLabel	"Imidazolone-5-propionate hydrolase"
RHEA:23660	skos:altLabel	"imidazolone propionic acid hydrolase"
RHEA:23660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate
RHEA:23660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"imidazolonepropionase"
RHEA:51537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP
REACT:R-DME-265429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Drosophila melanogaster)
REACT:R-DME-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Drosophila melanogaster)
REACT:R-DME-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Drosophila melanogaster)
REACT:R-MMU-2299620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen XI cross-links with collagen II (Mus musculus)
REACT:R-GGA-8964619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds ARHGEF6 (Gallus gallus)
REACT:R-RNO-373700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-9 binds DCC:DIP13alpha complex (Rattus norvegicus)
RHEA:33205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA
REACT:R-CFA-392195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi activation by P2Y purinoceptor 12 (Canis familiaris)
RHEA:38262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-beta-methylmalyl-CoA <=> glyoxylate + propanoyl-CoA
RHEA:22163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA
REACT:R-CEL-109538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Caenorhabditis elegans)
RHEA:58143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-AMP + cytidine(34) in elongator tRNA(Met) <=> AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)
REACT:R-HSA-266315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + spherical HDL <=> LCAT:spherical HDL complex (Homo sapiens)
REACT:R-CFA-5638157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)
RHEA:30147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FAD reductase (NADH)"
RHEA:30147	skos:prefLabel	"FAD reductase (NADH)"
RHEA:30147	skos:altLabel	"NADH-dependent FAD reductase"
RHEA:30147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + NAD(+) = FAD + 2 H(+) + NADH
REACT:R-HSA-156915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)
REACT:R-RNO-5660662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASC binds Caspase-8 complex (Rattus norvegicus)
REACT:R-RNO-159574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Rattus norvegicus)
RHEA:58410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + undecanal => NADP(+) + undecan-1-ol
REACT:R-DRE-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Danio rerio)
RHEA:51013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacyl-sn-glycero-3-phosphocholine + H2O => a monoacylglycerol + H(+) + phosphocholine
REACT:R-MMU-109823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)
REACT:R-HSA-1592310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan degradation by ADAMTSs (Homo sapiens)
REACT:R-MMU-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)
RHEA:72104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-propanoyl-(R)-carnitine(out) => Na(+)(in) + O-propanoyl-(R)-carnitine(in)
REACT:R-SSC-450434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Sus scrofa)
REACT:R-HSA-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Homo sapiens)
REACT:R-RNO-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)
REACT:R-DME-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Drosophila melanogaster)
REACT:R-HSA-9035281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H3 gene transcription regulated by NR1H2,3 (Homo sapiens)
REACT:R-HSA-5691507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPA deacetylates NAA to acetate and L-aspartate (Homo sapiens)
REACT:R-MMU-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Mus musculus)
RHEA:66831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate
REACT:R-XTR-8940388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPLD1 hydrolyses GPI-anchors from proteins (Xenopus tropicalis)
RHEA:51436	skos:altLabel	"2-amino-4-ketopentanoate thiolase"
RHEA:51436	skos:prefLabel	"2-amino-4-oxopentanoate thiolase"
RHEA:51436	skos:altLabel	"AKP thiolase"
RHEA:51436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-alanine = (2R)-2-amino-4-oxopentanoate + CoA
RHEA:51436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-amino-4-oxopentanoate thiolase"
REACT:R-DRE-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Danio rerio)
REACT:R-DME-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Drosophila melanogaster)
REACT:R-HSA-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Homo sapiens)
REACT:R-HSA-400092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Homo sapiens)
GO:0061920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein propionyltransferase activity
REACT:R-GGA-2855054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-2 binds to molecular patterns on the target cell surface  (Gallus gallus)
RHEA:69212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate
REACT:R-HSA-190687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in  ER-Golgi-Intermediate Compartment (Homo sapiens)
REACT:R-SSC-5579018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1(868-1441) binds PAX3(1-319) (Sus scrofa)
RHEA:15033	skos:prefLabel	"pyridoxine 4-oxidase"
RHEA:15033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pyridoxine = H2O2 + pyridoxal
RHEA:15033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxine 4-oxidase"
GO:0103075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate monooxygenase activity
RHEA:44436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol
REACT:R-CFA-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Canis familiaris)
REACT:R-CEL-3928617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB2 binds KALRN (Caenorhabditis elegans)
REACT:R-DRE-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Danio rerio)
REACT:R-DME-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Drosophila melanogaster)
GO:0044183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein binding involved in protein folding
GO:0044183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds GTP (Homo sapiens)
GO:0044183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein folding chaperone
GO:0044183	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chaperone activity
REACT:R-BTA-9624272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMPs cleave HB-EGF (Bos taurus)
REACT:R-SSC-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Sus scrofa)
REACT:R-MMU-5694487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A4GNT transfers GlcNAc to core 2 mucins (Mus musculus)
REACT:R-HSA-9684282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp9 forms a homodimer (Homo sapiens)
RHEA:45192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-DDI-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Dictyostelium discoideum)
GO:0019775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAT10 transferase activity
GO:0019775	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FAT10 conjugating enzyme activity
REACT:R-DME-1234183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Drosophila melanogaster)
RHEA:40159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose
RHEA:55942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-3,4-didehydroretinal + H(+) + NADH => all-trans-3,4-didehydroretinol + NAD(+)
RHEA:49988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetone monooxygenase (methyl acetate-forming)"
RHEA:49988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + H(+) + NADPH + O2 = H2O + methyl acetate + NADP(+)
RHEA:49988	skos:prefLabel	"acetone monooxygenase (methyl acetate-forming)"
REACT:R-HSA-1222462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SodB reduces superoxide to H2O2 (Homo sapiens)
REACT:R-HSA-350578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO1 interaction with ODC (Homo sapiens)
REACT:R-MMU-190258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c binds to FGF (Mus musculus)
RHEA:71353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone 3alpha-sulfate(in) + 2 Na(+)(in) => androsterone 3alpha-sulfate(out) + 2 Na(+)(out)
RHEA:50264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-434027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Phospho-IRF3 (Gallus gallus)
RHEA:72427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + K(+)(in) = chloride(out) + K(+)(out)
REACT:R-DRE-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Danio rerio)
REACT:R-CEL-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Caenorhabditis elegans)
RHEA:47939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + H2O + NADP(+) <=> 4-hydroxybenzoate + 2 H(+) + NADPH
RHEA:42476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2',3-trihydroxydiphenyl ether + H(+) + O2 = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate
GO:0018560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protocatechuate 3,4-dioxygenase type II activity
REACT:R-HSA-452100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to IL2 receptor is phosphorylated (Homo sapiens)
RHEA:37310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-asparagine + H2O <=> glycine + L-asparagine
RHEA:62447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-canavanine + L-ornithine <=> H(+) + L-arginine + L-canaline
RHEA:26295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-hydroxyversicolorone + H2O + NADP(+) => (1'S,5'S)-averufin + NADPH + O2
REACT:R-DME-199917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates CREB at Serine 133 (Drosophila melanogaster)
REACT:R-BTA-3858482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is recruited to the receptor (Bos taurus)
REACT:R-SCE-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Saccharomyces cerevisiae)
REACT:R-DRE-8856223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Danio rerio)
REACT:R-HSA-167115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 on HIV-1 transcript (Homo sapiens)
RHEA:39910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose <=> dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate
RHEA:36521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctacosanyol-CoA + CO2 + CoA => H(+) + hexacosanoyl-CoA + malonyl-CoA
GO:0008650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine (Homo sapiens)
GO:0008650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (uridine-2'-O-)-methyltransferase activity
RHEA:23558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-D-alanine + NH4(+) => D-alanine + L-glutamine
REACT:R-DRE-9667563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR2 bind desmopressin (Danio rerio)
REACT:R-DRE-71050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of the FASL:FAS receptor complex (Danio rerio)
REACT:R-HSA-166091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
RHEA:48810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2
RHEA:69128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-leucine = 4-methyl-2-oxopentanoate + glycine
REACT:R-SSC-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Sus scrofa)
REACT:R-XTR-5685607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sialic acid binds SIGLEC (Xenopus tropicalis)
RHEA:61778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + rebaudioside M + UDP => rebaudioside D + UDP-alpha-D-glucose
GO:0048273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK p38 binding
GO:0048273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitogen-activated protein kinase p38 binding
REACT:R-HSA-435244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM1 is phosphorylated (Homo sapiens)
RHEA:13743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + L-phenylalanine => 3-phenylpyruvate + L-tryptophan
RHEA:54461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate
GO:0002948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ArcS
GO:0002948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine:preQ0-tRNA amidinotransferase
GO:0002948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaeosine synthase activity
GO:0002948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"archaeosine synthase"
GO:0002948	skos:prefLabel	"archaeosine synthase"
GO:0002948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine = archaeosine(15) in tRNA + L-glutamate
RHEA:15508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxymethylglutarate + NAD(+) <=> 2-formylglutarate + H(+) + NADH
RHEA:11532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H2O + O2 = glyoxylate + H2O2 + NH4(+)
RHEA:65260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	verruculide C epoxide = 3-hydroxypentacecilide A
RHEA:17745	skos:altLabel	"NAL synthetase"
RHEA:17745	skos:prefLabel	"N-acetyllactosamine synthase"
RHEA:17745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP
RHEA:17745	skos:altLabel	"acetyllactosamine synthetase"
RHEA:17745	skos:altLabel	"UDP-galactose--N-acetylglucosamine beta-D-galactosyltransferase"
RHEA:17745	skos:altLabel	"UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase"
RHEA:17745	skos:altLabel	"N-acetylglucosamine (beta1,4)galactosyltransferase"
RHEA:17745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyllactosamine synthase"
RHEA:62301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)
RHEA:13469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + thymine = 5-methylbarbiturate + AH2 + H(+)
RHEA:22695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoate + H2O + NAD(+)
RHEA:65245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hesperetin + UDP-alpha-D-glucose => (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP
RHEA:62228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ascladiol + A = AH2 + patulin
REACT:R-XTR-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Xenopus tropicalis)
REACT:R-MMU-844447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 senses MDP (Mus musculus)
RHEA:40867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + FAD + H(+) = (2E,9E)-octadecadienoyl-CoA + FADH2
RHEA:46621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol => (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
RHEA:53884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + CDP + H(+)
RHEA:72407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + Li(+)(out) = H(+)(out) + Li(+)(in)
REACT:R-RNO-2065550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds Importin beta-1 (Rattus norvegicus)
REACT:R-CEL-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Caenorhabditis elegans)
REACT:R-CEL-5138433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Caenorhabditis elegans)
REACT:R-HSA-420739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPRC6A can bind L-alpha amino acids and calcium (Homo sapiens)
GO:0047979	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-hexose:oxygen 1-oxidoreductase activity
GO:0047979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexose oxidase activity
REACT:R-HSA-391155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRPA binds SFTPA oligomer, SFTPD oligomer (Homo sapiens)
REACT:R-MMU-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Mus musculus)
GO:0034947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terephthalate decarboxylase activity
REACT:R-CFA-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Canis familiaris)
REACT:R-CFA-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Canis familiaris)
REACT:R-DRE-176669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Danio rerio)
RHEA:50451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + prostaglandin G3 <=> A + H2O + prostaglandin H3
RHEA:19234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-hexadecanoyl-L-cysteinyl-[protein] => H(+) + hexadecanoate + L-cysteinyl-[protein]
REACT:R-HSA-1236956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfment of particulate antigen into phagocytic vesicle (Homo sapiens)
REACT:R-XTR-4551604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO1 (Xenopus tropicalis)
REACT:R-MMU-8869627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NR to yield NMN (Mus musculus)
RHEA:27659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-alpha-D-ribose 1-phosphate => 2-deoxy-D-ribose 5-phosphate
RHEA:23326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-beta-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide => 2'-phospho-[ligated tRNA] + NAD(+)
RHEA:43911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O <=> D-galactose + sphing-4-enine
REACT:R-SPO-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)
REACT:R-RNO-2247512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Rattus norvegicus)
RHEA:41742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine => adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine
RHEA:66737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-citrylglutamate(in) + H2O => ADP + beta-citrylglutamate(out) + H(+) + phosphate
REACT:R-RNO-1006143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C3b (Rattus norvegicus)
RHEA:61223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)
REACT:R-DDI-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Dictyostelium discoideum)
GO:0008607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylase kinase regulator activity
GO:0008607	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphorylase kinase, intrinsic regulator activity
RHEA:67070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + asnovolin J => AH2 + chermesin D methyl ester
RHEA:43774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine
RHEA:45004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 2,6-dimethylheptanoyl-CoA = CoA + O-2,6-dimethylheptanoyl-(R)-carnitine
RHEA:51702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthogalenol
REACT:R-HSA-8961021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD binds with itself to form SFTPD 12mer (Homo sapiens)
RHEA:45169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (E)-sinapoyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine
REACT:R-CFA-9707690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 binds MAFK (Canis familiaris)
REACT:R-MMU-9618021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXG1 binds FOXO:SMAD complexes (Mus musculus)
GO:0015139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate transmembrane transporter activity
GO:0015139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate transporter activity
GO:0015139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)
REACT:R-MMU-1295604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-RAF dissociates from S111/S120 p-SPRY2 (Mus musculus)
RHEA:27727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate
REACT:R-RNO-453111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
RHEA:47402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z)-hexadecenoyl-CoA + acetyl-CoA => 3-oxo-(9Z-octadecenoyl)-CoA + CoA
REACT:R-DRE-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Danio rerio)
RHEA:48058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosylceramide + D-galactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O
RHEA:32388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocarveol + NAD(+) => dihydrocarvone + H(+) + NADH
RHEA:32054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> adenosine 5'-tetraphosphate + AMP + 2 H(+)
RHEA:22842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate + NH4(+) => D-glutamine + H2O
REACT:R-MMU-879674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD97 binds CD55 (Mus musculus)
REACT:R-BTA-201423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI complexes with the Smad complex, suppressing BMP2 signalling (Bos taurus)
RHEA:27498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-O-methyltricetin + S-adenosyl-L-methionine => 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine
RHEA:43534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-phosphate + phosphate => a ribonucleoside 3',5'-bisphosphate + H2O
REACT:R-CFA-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Canis familiaris)
REACT:R-RNO-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Rattus norvegicus)
REACT:R-CFA-5610752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R translocates to the nucleus (Canis familiaris)
RHEA:44542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O
GO:0047022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0047022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent 7beta-hydroxysteroid dehydrogenase activity
GO:0047022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7beta-hydroxysteroid dehydrogenase (NADP+)
GO:0047022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity
GO:0047022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity
RHEA:61379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate
REACT:R-HSA-5621353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Homo sapiens)
RHEA:38473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine => L-histidine + 3 S-adenosyl-L-methionine
REACT:R-MMU-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Mus musculus)
RHEA:44807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-9 + CO2 + diphosphate
REACT:R-CFA-5690046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT2 hydrolyses PALMCoA to PALM (Canis familiaris)
REACT:R-MMU-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Mus musculus)
RHEA:64087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) <=> 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2
RHEA:19082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-haloalkane + H2O => a halide anion + a primary alcohol + H(+)
RHEA:54407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
RHEA:56047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)
GO:0098847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence-specific single stranded DNA binding
REACT:R-DRE-391933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP3 receptor can bind PGE2 (Danio rerio)
REACT:R-DRE-1433428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)
REACT:R-SSC-5634729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)
GO:0008940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate reductase (acceptor)
GO:0008940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite:acceptor oxidoreductase
GO:0008940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate reductase activity
GO:0008940	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	respiratory nitrate reductase activity
GO:0008940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite:(acceptor) oxidoreductase
RHEA:15553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-1,4-bisphosphate 1-phosphatase"
RHEA:15553	skos:prefLabel	"inositol-1,4-bisphosphate 1-phosphatase"
RHEA:15553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate
RHEA:15553	skos:altLabel	"inositol polyphosphate 1-phosphatase"
RHEA:56460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine
REACT:R-RNO-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Rattus norvegicus)
RHEA:49925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-acyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acyl-(R)-carnitine(out)
REACT:R-MMU-9634702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Mus musculus)
REACT:R-BTA-6782138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC5 and RPA bind TC-NER site (Bos taurus)
GO:0050260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonia-ribose 5-phosphate aminotransferase activity
GO:0050260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribose-5-phosphate:ammonia ligase (ADP-forming)
GO:0050260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose-5-phosphate-ammonia ligase activity
GO:0050260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphoribosylamine synthetase activity
GO:0050260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribose 5-phosphate aminotransferase activity
REACT:R-SSC-448629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33 binds IL1RL1 (Sus scrofa)
RHEA:33924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)
REACT:R-SPO-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Schizosaccharomyces pombe)
REACT:R-BTA-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Bos taurus)
REACT:R-DRE-191763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP:Snurportin complex formation (Danio rerio)
RHEA:21822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionine + S-adenosyl-L-homocysteine => L-homocysteine + S-adenosyl-L-methionine
REACT:R-CFA-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Canis familiaris)
REACT:R-BTA-5678313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Bos taurus)
REACT:R-DME-112342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of MAP2K1 by CDK1 (Drosophila melanogaster)
REACT:R-RNO-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Rattus norvegicus)
REACT:R-GGA-418106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Packaging of telomere ends (Gallus gallus)
REACT:R-HSA-9771686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp12 acquires Fe-S cluster cofactors (Homo sapiens)
RHEA:29130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + nitrate <=> a menaquinone + H2O + nitrite
REACT:R-HSA-9710480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decitabine triphosphate incorporates into DNA (Homo sapiens)
REACT:R-HSA-5690827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 (Homo sapiens)
RHEA:14106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NAD(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADH
RHEA:10019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-sinapoylcholine <=> (E)-sinapate + choline + H(+)
RHEA:32349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + tricetin
REACT:R-DDI-75825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of Cyclin D1 (Dictyostelium discoideum)
RHEA:39598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH <=> (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)
GO:0102631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoylglucose 3-O-methyltransferase activity
REACT:R-DDI-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Dictyostelium discoideum)
REACT:R-RNO-5654623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS3 (Rattus norvegicus)
REACT:R-DRE-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Danio rerio)
RHEA:25966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzil + H(+) + NADPH => (R)-benzoin + NADP(+)
REACT:R-HSA-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
REACT:R-DME-190261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3c binds to FGF (Drosophila melanogaster)
RHEA:28837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + succinate(out) => citrate(out) + succinate(in)
REACT:R-BTA-1855162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Bos taurus)
REACT:R-HSA-418849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAPK binds UNC5B (Homo sapiens)
RHEA:11737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-exo-hydroxy-1,8-cineole + NAD(+) => 6-oxocineole + H(+) + NADH
REACT:R-BTA-5682690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 dissociates from ATG12:ATG5 (Bos taurus)
REACT:R-CFA-5635839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3:SUFU dissociates (Canis familiaris)
RHEA:62596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH
RHEA:31784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tuberculosinyl diphosphate => diphosphate + tuberculosinol
RHEA:59491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:45551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]
RHEA:55519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-74711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRS (Danio rerio)
REACT:R-SSC-199161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fc gamma receptors interact with antigen-bound IgG (Sus scrofa)
REACT:R-BTA-177933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by phosphorylated EGFR (Bos taurus)
REACT:R-CFA-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Canis familiaris)
GO:0018497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDMS dehydrogenase activity
GO:0018497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity
REACT:R-XTR-4719447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO1 (Xenopus tropicalis)
RHEA:13733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an n-alkanal + NAD(+) = an alk-2-enal + H(+) + NADH
REACT:R-BTA-9627056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procaspase 9 forms dimer (Bos taurus)
REACT:R-SSC-5693580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD52 with the RPA complex at resected DNA DSBs (Sus scrofa)
REACT:R-DDI-9641089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin binds Ub:UBE2N:UBE2V1 (Dictyostelium discoideum)
RHEA:37527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:13959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 H(+) + 2 hydrogen sulfide + 2 sulfite => 4 H2O + O2 + 4 sulfur
REACT:R-RNO-173481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Rattus norvegicus)
RHEA:68260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(in) + Na(+)(in) = D-serine(out) + Na(+)(out)
REACT:R-BTA-8980228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Bos taurus)
REACT:R-XTR-8987220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Xenopus tropicalis)
GO:0043364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-radical enzyme activating activity
GO:0043364	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	catalysis of free radical formation
RHEA:18014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-ethyl-L-glutamine => ethylamine + L-glutamate
REACT:R-MMU-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Mus musculus)
REACT:R-RNO-192054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Rattus norvegicus)
REACT:R-PFA-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Plasmodium falciparum)
RHEA:61608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbB protein]-dithiol + a quinone = [DsbB protein]-disulfide + a quinol
RHEA:25043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-selenocysteinyl-tRNA(Sec) + 2 phosphate => H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate
REACT:R-DME-5362427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds GPC5 (Drosophila melanogaster)
REACT:R-RNO-9756177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)
RHEA:72478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate(in) + citrate(out) <=> cis-aconitate(out) + citrate(in)
GO:0003689	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PCNA loading complex activity
GO:0003689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA clamp loading ATPase activity
GO:0003689	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PCNA loading activity
GO:0003689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Homo sapiens)
GO:0003689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-DNA loading ATPase activity
GO:0003689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)
GO:0003689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-protein loading ATPase activity
GO:0003689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA clamp loader activity
RHEA:37358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + uridine 2'-phosphate <=> phosphate + uridine
REACT:R-RNO-4090390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates AR with SUMO1 (Rattus norvegicus)
RHEA:25431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-hexosamine <=> ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate
RHEA:46927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoyl-CoA <=> 4-methylpent-2-enoyl-CoA + H2O
REACT:R-BTA-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Bos taurus)
REACT:R-CFA-5686440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81:EME1,EME2 cleaves D-loop (Canis familiaris)
REACT:R-RNO-4655355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Rattus norvegicus)
REACT:R-DME-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Drosophila melanogaster)
REACT:R-RNO-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Rattus norvegicus)
GO:0047468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglucomutase (glucose-cofactor) activity
GO:0047468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose-1-phosphate phosphotransferase activity
GO:0047468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)
RHEA:72765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A11 + CoA => anthocyanin A10 + malonyl-CoA
RHEA:65264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypentacecilide A + A = AH2 + chrodrimanin C
GO:0047791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitacin D23-reductase activity
GO:0047791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity
GO:0047791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitacin delta(23) reductase activity
GO:0047791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H: cucurbitacin B delta23-oxidoreductase activity
GO:0047791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitacin delta23-reductase activity
RHEA:21342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 vanillin => 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2
RHEA:20559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 NH4(+) => 2 H(+) + H2O + urea
REACT:R-CFA-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Canis familiaris)
RHEA:47061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-XTR-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Xenopus tropicalis)
RHEA:38104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactonate => 2-dehydro-3-deoxy-L-galactonate + H2O
RHEA:17819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
GO:0015205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleobase transmembrane transporter activity
RHEA:47861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b (d18:1(4E)) + H2O => ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate
REACT:R-HSA-5676926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methionine sulfoxide is oxidised to methionine sulfone (Homo sapiens)
REACT:R-CFA-1604350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14:TIMP2 binds proMMP2 (Canis familiaris)
REACT:R-GGA-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Gallus gallus)
REACT:R-HSA-1980078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 stimulates HES5 transcription (Homo sapiens)
RHEA:66082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine
RHEA:13086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O => CoA + L-2-acetamido-6-oxoheptanedioate
GO:0004983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuropeptide Y receptor activity
REACT:R-SSC-5665767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FMNL3 binds G-actin (Sus scrofa)
RHEA:15343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate => ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide
RHEA:11142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate => alpha-D-mannose 1-phosphate
REACT:R-GGA-3769391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 binds the beta-catenin:CBY complex (Gallus gallus)
RHEA:31193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + H2O => (3S)-hydroxydecanoyl-CoA
RHEA:57449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-tyrosine + tRNA(Tyr) => AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)
RHEA:19390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + ADP + phosphate
REACT:R-HSA-5669302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds RORA gene (Homo sapiens)
REACT:R-RNO-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Rattus norvegicus)
RHEA:21388	skos:altLabel	"L-alpha-aminocaprolactam hydrolase"
RHEA:21388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminohexano-6-lactam = L-lysine
RHEA:21388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-lysine-lactamase"
RHEA:21388	skos:prefLabel	"L-lysine-lactamase"
RHEA:21388	skos:altLabel	"L-lysinamidase"
GO:0016763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring pentosyl groups
GO:0016763	skos:prefLabel	"Pentosyltransferases"
GO:0016763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentosyltransferase activity
GO:0016763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Pentosyltransferases"
REACT:R-DME-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Drosophila melanogaster)
REACT:R-SCE-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Saccharomyces cerevisiae)
REACT:R-CEL-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Caenorhabditis elegans)
REACT:R-BTA-174438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate on the C-strand (Bos taurus)
REACT:R-SPO-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Schizosaccharomyces pombe)
RHEA:37448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetracenomycin F1 => H(+) + H2O + tetracenomycin D3
RHEA:20966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + L-kynurenine
REACT:R-RNO-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Rattus norvegicus)
REACT:R-GGA-8865265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds MYC and KDM5B (Gallus gallus)
REACT:R-GGA-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Gallus gallus)
REACT:R-GGA-1306957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
RHEA:49510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylmalate
REACT:R-HSA-9614564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO4 (Homo sapiens)
REACT:R-DRE-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Danio rerio)
REACT:R-RNO-202174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ZAP-70 (Rattus norvegicus)
RHEA:45070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-acyl-(R)-carnitine => (R)-carnitine + an acyl-CoA
REACT:R-HSA-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Homo sapiens)
EC:3.5.2.19	skos:prefLabel	"streptothricin hydrolase"
EC:3.5.2.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"streptothricin hydrolase"
REACT:R-PFA-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Plasmodium falciparum)
GO:0016779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THG1L transfers GMP to 5' end of tRNA(His) (Homo sapiens)
GO:0016779	skos:prefLabel	"Nucleotidyltransferases"
GO:0016779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Nucleotidyltransferases"
GO:0016779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotidyltransferase activity
REACT:R-SSC-168947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand binds to TLR10 (Sus scrofa)
RHEA:58484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(acetyl)-sphing-4-enine = acetate + sphing-4-enine
REACT:R-CFA-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Canis familiaris)
RHEA:28011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanoyl-CoA + succinate => propanoate + succinyl-CoA
REACT:R-MMU-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Mus musculus)
RHEA:44875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-BTA-373732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin trans-homophilic interaction (Bos taurus)
RHEA:29154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)
RHEA:51130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + an aldehyde + NH4(+) => A + an aliphatic amine + H2O
REACT:R-CFA-8964340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq-BTK complex dissociates to Active BTK and Gq (Canis familiaris)
REACT:R-XTR-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-HSA-5663155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds NR1D1 gene (Homo sapiens)
REACT:R-BTA-110248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 3-methyladenine by MPG glycosylase  (Bos taurus)
RHEA:54029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:40994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA
REACT:R-HSA-9696268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds effectors (Homo sapiens)
REACT:R-DRE-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Danio rerio)
GO:0008809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine racemase activity
REACT:R-BTA-2404193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1R phosphorylates SHC1 (Bos taurus)
REACT:R-MMU-202722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD48 binds CD244 (Mus musculus)
REACT:R-RNO-451900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RB binds JAK1 (Rattus norvegicus)
REACT:R-CFA-3000074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN2 binds RCbl in the circulation (Canis familiaris)
REACT:R-DME-451311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca-permeable Kainate receptors (Drosophila melanogaster)
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-hydroxylase-25-hydroxyvitamin D3 activity
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol 1-monooxygenase activity
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	25-hydroxyvitamin D-1 alpha hydroxylase activity
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxy vitamin D3 1-alpha-hydroxylase activity
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	25-hydroxycholecalciferol 1alpha-hydroxylase activity
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	25-hydroxyvitamin D3 1alpha-hydroxylase activity
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	25-OHD-1 alpha-hydroxylase activity
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP27B
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	25-hydroxycholecalciferol-1-hydroxylase activity
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholecalciferol 1-hydroxylase activity
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	25-hydroxy D3-1alpha-hydroxylase activity
GO:0004498	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	25-hydroxycholecalciferol 1-monooxygenase activity
REACT:R-CEL-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Caenorhabditis elegans)
REACT:R-BTA-8856525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANGPTL8 binds ANGPTL3 (Bos taurus)
RHEA:20907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxypropyl-coenzyme M <=> (S)-1,2-epoxypropane + coenzyme M
REACT:R-HSA-9705458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT1,3,5 dimer enhances expression of SOCS3 (Homo sapiens)
REACT:R-DRE-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
REACT:R-HSA-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Homo sapiens)
REACT:R-MMU-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Mus musculus)
REACT:R-CFA-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Canis familiaris)
REACT:R-XTR-418176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB2 binds MAPKs, SRC-1 (Xenopus tropicalis)
REACT:R-CFA-9025995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Canis familiaris)
GO:0102144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyspermidine dehydrogenase II activity
REACT:R-SSC-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Sus scrofa)
RHEA:35506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-2327738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Danio rerio)
REACT:R-DRE-937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 (Danio rerio)
REACT:R-DRE-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Danio rerio)
REACT:R-GGA-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Gallus gallus)
GO:0009000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	selenocysteine beta-lyase activity
GO:0009000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-selenocysteine selenide-lyase (L-alanine-forming)
GO:0009000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	selenocysteine reductase activity
GO:0009000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenocysteine lyase activity
REACT:R-HSA-1299478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPP cleaves targeting peptide (presequence) of matrix precursors (Homo sapiens)
RHEA:50111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + taurine <=> CoA + H(+) + N-hexadecanoyl-taurine
RHEA:33414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O <=> (S)-malyl alpha-D-glucosaminide + acetate
RHEA:36857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + H2O
RHEA:17519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + L-glutamate => H2O + N-(long-chain-fatty-acyl)-L-glutamate
RHEA:48640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH
REACT:R-DME-9701531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727 STAT3 is acetylated (Drosophila melanogaster)
RHEA:49868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid + a quinone = (+)-dehydrodiconiferyl acid ketone + a quinol
RHEA:10580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate
REACT:R-MMU-5625421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The anterograde IFT train dissociates (Mus musculus)
RHEA:33344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => 2-iminoacetate + H2O2
GO:0080017	skos:prefLabel	"alpha-humulene synthase"
GO:0080017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-humulene synthase"
GO:0080017	skos:altLabel	"ZSS1"
GO:0080017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-humulene synthase activity
GO:0080017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate
REACT:R-CEL-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Caenorhabditis elegans)
REACT:R-CFA-751001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (i) reassociates with G beta:gamma (Canis familiaris)
RHEA:63895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-tryptophan <=> AMP + D-tryptophan + diphosphate + H(+)
RHEA:70490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 <=> a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate
REACT:R-BTA-444606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R2/T1R3 dimer is a sweet taste receptor (Bos taurus)
REACT:R-CEL-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Caenorhabditis elegans)
GO:0120300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]
GO:0120300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide lactyltransferase activity
RHEA:20536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyridoxal 5'-phosphate <=> phosphate + pyridoxal
RHEA:14569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"propanediol dehydratase"
RHEA:14569	skos:prefLabel	"propanediol dehydratase"
RHEA:14569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propane-1,2-diol = H2O + propanal
RHEA:48484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a propanoate ester + H2O = an aliphatic alcohol + H(+) + propanoate
REACT:R-BTA-211968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2W1 oxidises INDOL (Bos taurus)
REACT:R-XTR-1602473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP1 (Xenopus tropicalis)
REACT:R-BTA-9756134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Bos taurus)
RHEA:28223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + ATP => 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)
RHEA:16112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)
REACT:R-HSA-2454240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)
REACT:R-RNO-382061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular processing of novel PDGFs (Rattus norvegicus)
RHEA:24311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-9012000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Xenopus tropicalis)
RHEA:51253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
REACT:R-MMU-3296309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR3 binds HCAR3 ligands (Mus musculus)
REACT:R-CEL-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)
REACT:R-PFA-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Plasmodium falciparum)
REACT:R-BTA-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Bos taurus)
REACT:R-CFA-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Canis familiaris)
REACT:R-MMU-6800380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAP-1 (Mus musculus)
RHEA:50840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate
REACT:R-DRE-9627350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) binds XIAP (Danio rerio)
RHEA:29149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + H2O + nitrite + ubiquinone-8 => 2 H(+)(in) + nitrate + ubiquinol-8
RHEA:47379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-GGA-8851044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN1A1 binds xanthine oxidoreductase (XDH) (Gallus gallus)
REACT:R-DDI-8865637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFSD2A transports LPC from extracellular region to plasma membrane (Dictyostelium discoideum)
RHEA:33058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 3'-diphosphate 5'-triphosphate + H2O <=> diphosphate + GTP + H(+)
RHEA:31912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1,6-bisphosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate
RHEA:17384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate <=> (9Z,11E)-octadecadienoate
REACT:R-CEL-9638125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G1P to G6P (Caenorhabditis elegans)
REACT:R-SSC-2187325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)
REACT:R-DRE-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Danio rerio)
REACT:R-DRE-73945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAS-mediated dimerization of procaspase-8 (Danio rerio)
RHEA:41429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + S-adenosyl-L-methionine => 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-1369017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in muscle cells (Xenopus tropicalis)
REACT:R-GGA-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Gallus gallus)
REACT:R-SSC-3249392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Sus scrofa)
RHEA:67873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose => 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP
RHEA:24308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Dictyostelium discoideum)
RHEA:52971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyocholate + UDP-alpha-D-glucuronate <=> H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP
RHEA:64533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:42817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol => cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
RHEA:67353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + rhaponticin => 6-O-malonyl-rhaponticin + CoA
REACT:R-CFA-5362553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTUM releases Hh-Np:GPC5 from the plasma membrane (Canis familiaris)
GO:0047649	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-alkylglycerol phosphotransferase activity
GO:0047649	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-alkyl-sn-glycerol phosphotransferase activity
GO:0047649	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity
GO:0047649	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkylglycerol kinase (phosphorylating)
GO:0047649	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylglycerol phosphotransferase activity
GO:0047649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylglycerol kinase activity
RHEA:23253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate
REACT:R-CEL-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Caenorhabditis elegans)
REACT:R-CFA-2309779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer binds PTGS2 inhibitors (Canis familiaris)
RHEA:30365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate => fumonisin B1 + 2 H2O
REACT:R-XTR-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
REACT:R-XTR-420739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPRC6A can bind L-alpha amino acids and calcium (Xenopus tropicalis)
REACT:R-DME-198609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates TSC2, inhibiting it (Drosophila melanogaster)
RHEA:29423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + diphosphate = ADP + H(+) + triphosphate
RHEA:43431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycerol + ATP <=> 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)
RHEA:21379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + O2 <=> (S)-4-hydroxymandelate + CO2
RHEA:66140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + octopamine = CoA + H(+) + N-acetyloctopamine
GO:0052762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gellan lyase activity
RHEA:62659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate <=> 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate
RHEA:31211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-selenomethionine = diphosphate + L-adenosylselenomethionine + phosphate
REACT:R-RNO-5654603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS3 (Rattus norvegicus)
RHEA:17279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O => 6-phospho-D-gluconate
REACT:R-DME-3245898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds correnoids in the circulation (Drosophila melanogaster)
REACT:R-HSA-8937631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Homo sapiens)
REACT:R-CFA-165692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of 4E-BP1 by activated mTORC1 (Canis familiaris)
REACT:R-GGA-432110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Gallus gallus)
RHEA:58993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamaldehyde + H2O + O2 => (E)-cinnamate + H(+) + H2O2
RHEA:40265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanedioyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanedioyl-CoA + NAD(+)
REACT:R-CEL-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Caenorhabditis elegans)
RHEA:33003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:42888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mevalonate-3-phosphate 5-kinase"
RHEA:42888	skos:prefLabel	"mevalonate-3-phosphate 5-kinase"
RHEA:42888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phosphomevalonate + ATP = (R)-3,5-bisphosphomevalonate + ADP + H(+)
RHEA:28271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + spermidine => CoA + H(+) + N(8)-acetylspermidine
REACT:R-GGA-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Gallus gallus)
REACT:R-SSC-1237081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Sus scrofa)
GO:0047182	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity
GO:0047182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol O-cinnamoyltransferase activity
RHEA:39495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)
REACT:R-DRE-4793925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S303,307-HSF1 binds YWHAE (14-3-3) (Danio rerio)
REACT:R-CEL-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Caenorhabditis elegans)
RHEA:22862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deamido-NAD(+) + diphosphate => ATP + H(+) + nicotinate beta-D-ribonucleotide
REACT:R-DME-141348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAO:FAD oxidises NASPM to PTCN (Drosophila melanogaster)
RHEA:26314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => dihydroxyacetone phosphate + L-aspartate 4-semialdehyde
REACT:R-DRE-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Danio rerio)
REACT:R-GGA-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Gallus gallus)
REACT:R-SPO-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Schizosaccharomyces pombe)
REACT:R-XTR-8938073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Xenopus tropicalis)
REACT:R-SSC-209738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 binds GC (Sus scrofa)
REACT:R-SSC-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Sus scrofa)
RHEA:28057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CoA <=> formate + propanoyl-CoA
REACT:R-GGA-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Gallus gallus)
REACT:R-DME-3215385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Drosophila melanogaster)
REACT:R-GGA-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Gallus gallus)
REACT:R-GGA-374669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds NRP1 (Gallus gallus)
RHEA:55517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)
REACT:R-MMU-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Mus musculus)
REACT:R-DME-6809254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR8 binds MTMR9 (Drosophila melanogaster)
REACT:R-XTR-933536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7 dimer interacts with coactivator CBP/p300 (Xenopus tropicalis)
RHEA:40927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)
RHEA:17240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + FMN + H(+) <=> diphosphate + FAD
REACT:R-DDI-2537665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin-1 and -2 bind fibronectin (Dictyostelium discoideum)
GO:0042017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-22 binding
GO:0042017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-22 binding
REACT:R-HSA-193065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Homo sapiens)
RHEA:23711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)
REACT:R-CEL-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Caenorhabditis elegans)
REACT:R-RNO-194187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-GGA-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Gallus gallus)
REACT:R-HSA-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
RHEA:17941	skos:prefLabel	"2-methylisocitrate dehydratase"
RHEA:17941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O
RHEA:17941	skos:altLabel	"(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase"
RHEA:17941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methylisocitrate dehydratase"
REACT:R-SCE-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Saccharomyces cerevisiae)
REACT:R-RNO-177943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to EGF:EGFR complex (Rattus norvegicus)
RHEA:10599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tyrosyl-[protein] <=> ADP + H(+) + O-phospho-L-tyrosyl-[protein]
GO:0018461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-fluorenol dehydrogenase activity
GO:0018461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fluoren-9-ol:NAD(P)+ oxidoreductase activity
GO:0018461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoren-9-ol dehydrogenase activity
RHEA:43520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-5-(dihydroxymethyl)furan + O2 = 2,5-dicarboxyfuran + H(+) + H2O2
REACT:R-HSA-3364014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SET1 methyltransferase complex (Homo sapiens)
REACT:R-RNO-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Rattus norvegicus)
RHEA:69500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + NAD(+) = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide
REACT:R-GGA-1181153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Gallus gallus)
RHEA:59256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-enterobactin + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)
REACT:R-MMU-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Mus musculus)
REACT:R-MMU-2453855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)
GO:0030984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kininogen binding
RHEA:43817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-HSA-3791149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Homo sapiens)
REACT:R-SCE-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Saccharomyces cerevisiae)
GO:0102770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol phosphorylceramide synthase activity
REACT:R-GGA-421416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proglucagon translocates from the ER Lumen to secretory granules (Gallus gallus)
REACT:R-BTA-9647632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDME (Bos taurus)
RHEA:21071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + nitrite <=> AH2 + nitrate
REACT:R-RNO-168849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAX protein (Rattus norvegicus)
REACT:R-DDI-3215406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds WDR77 (Dictyostelium discoideum)
REACT:R-BTA-114252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-3 by the apoptosome (Bos taurus)
REACT:R-GGA-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Gallus gallus)
REACT:R-MMU-9617996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Mus musculus)
RHEA:69043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 <=> 2-nitrobutanedioate + H2O + NADP(+)
REACT:R-XTR-8848335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37 binds  IL18R1 (Xenopus tropicalis)
RHEA:28216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + prostaglandin F2alpha => [thioredoxin]-dithiol + prostaglandin H2
RHEA:21788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate
REACT:R-CEL-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
REACT:R-RNO-158795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Rattus norvegicus)
REACT:R-XTR-6814670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Xenopus tropicalis)
GO:0034039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0034039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxoG DNA N-glycosylase activity
GO:0033791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity
GO:0033791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	THCA-CoA oxidase activity
GO:0033791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
GO:0033791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity
GO:0033791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trihydroxycoprostanoyl-CoA oxidase activity
GO:0033791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	THC-CoA oxidase activity
GO:0033791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity
REACT:R-SSC-500717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GRIK3 homomer (Sus scrofa)
RHEA:28243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pratensein + reduced [NADPH--hemoprotein reductase] => 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:63532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin I + H2O = angiotensin-(1-9) + L-leucine
REACT:R-MMU-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Mus musculus)
REACT:R-BTA-909722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-STAT2:p-STAT1 dimer (Bos taurus)
RHEA:59534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-codamine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine
REACT:R-DRE-163843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-GAS6 to GAS6 (Danio rerio)
REACT:R-CFA-381135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)
RHEA:68941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) + tellurite(in) => Na(+)(out) + tellurite(out)
REACT:R-RNO-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Rattus norvegicus)
RHEA:48551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O <=> [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol
RHEA:33190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
RHEA:72086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-beta-D-ribose 1'',2''-cyclic phosphate + H2O <=> ADP-beta-D-ribose 1''-phosphate + H(+)
REACT:R-DDI-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Dictyostelium discoideum)
RHEA:29004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-homoserine(in) => H(+)(in) + L-homoserine(out)
REACT:R-DME-2730856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Drosophila melanogaster)
REACT:R-SCE-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Saccharomyces cerevisiae)
REACT:R-HSA-8851908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 (Homo sapiens)
RHEA:21403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CoA + NADP(+) <=> CO2 + NADPH + succinyl-CoA
RHEA:38519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)
RHEA:11749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetaldehyde + L-threonine => 4-fluoro-L-threonine + acetaldehyde
REACT:R-XTR-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Xenopus tropicalis)
RHEA:30624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-neurosporene => AH2 + all-trans-lycopene
EC:3.4.21.76	skos:altLabel	"proteinase 3"
EC:3.4.21.76	skos:prefLabel	"myeloblastin"
EC:3.4.21.76	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"myeloblastin"
EC:3.4.21.76	skos:altLabel	"leukocyte proteinase 3"
EC:3.4.21.76	skos:altLabel	"Wegener's autoantigen"
RHEA:69493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octan-1-ol => H2O2 + octanal
RHEA:44493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
GO:0050692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBD binding
GO:0050692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA binding domain binding
REACT:R-SSC-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Sus scrofa)
REACT:R-CFA-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Canis familiaris)
GO:0047914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-GHA synthetase activity
GO:0047914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutaminylhistamine synthetase activity
GO:0047914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:histamine ligase activity
GO:0047914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	g-glutamylhistamine synthase activity
GO:0047914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-glutamylhistamine synthase activity
GO:0044603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein deAMPylation activity
GO:0044603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein deAMPylase activity
GO:0044603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein adenylylhydrolase activity
REACT:R-GGA-2029273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to p-6Y-SYK (Gallus gallus)
REACT:R-SSC-8936851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHRR binds ARNT (Sus scrofa)
GO:0015476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hemaglutinin autotransporter activity
RHEA:41485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-HSA-5687640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)
REACT:R-DME-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Drosophila melanogaster)
RHEA:37613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol
REACT:R-HSA-6783483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)
RHEA:30135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)
REACT:R-BTA-9706390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds interacting proteins at trans-Golgi network (Bos taurus)
RHEA:43800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DME-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Drosophila melanogaster)
REACT:R-MMU-210304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with PECAM1 (Mus musculus)
GO:0043115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosirohydrochlorin dehydrogenase activity
GO:0043115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	precorrin-2 oxidase activity
GO:0043115	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	siroheme synthase activity
GO:0043115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SirC
GO:0043115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	precorrin-2:NAD+ oxidoreductase activity
GO:0043115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-2 dehydrogenase activity
GO:0043115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Met8p
GO:0043115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CysG
GO:0043115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dimethyluroporphyrinogen III dehydrogenase activity
REACT:R-CFA-77331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Canis familiaris)
RHEA:71463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8)
RHEA:19546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 3-phosphocholine => glycerol + H(+) + phosphocholine
EC:2.4.2.3	skos:altLabel	"UrdPase"
EC:2.4.2.3	skos:prefLabel	"uridine phosphorylase"
EC:2.4.2.3	skos:altLabel	"UPase"
EC:2.4.2.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uridine phosphorylase"
EC:2.4.2.3	skos:altLabel	"pyrimidine phosphorylase"
REACT:R-RNO-5602295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F22 20-hydroxylates TrXA3 (Rattus norvegicus)
RHEA:39713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) => O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-RNO-374173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR1 (Rattus norvegicus)
REACT:R-GGA-6814670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Gallus gallus)
REACT:R-CFA-5676592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xRANK binds RANKL,sRANKL trimer:RANK (Canis familiaris)
REACT:R-HSA-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Homo sapiens)
RHEA:38281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalyl-CoA + succinate => (3R)-citramalate + succinyl-CoA
RHEA:30685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-D-mannosamine + UDP => H2O + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-CFA-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Canis familiaris)
RHEA:69630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:20202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-phenylalanine => AMP + D-phenylalanine + diphosphate + H(+)
GO:0033965	skos:prefLabel	"aculeacin-A deacylase"
GO:0033965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aculeacin-A deacylase"
GO:0033965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculeacin-A deacylase activity
GO:0033965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aculeacin A acylase activity
GO:0033965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aculeacin-A amidohydrolase activity
RHEA:23488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)
RHEA:23488	skos:prefLabel	"p-benzoquinone reductase (NADPH)"
RHEA:23488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"p-benzoquinone reductase (NADPH)"
REACT:R-SSC-8874082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates PTK2 (Sus scrofa)
RHEA:59301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + firefly D-luciferin => adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)
REACT:R-HSA-1296024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in neuroendocrine cells (Homo sapiens)
RHEA:54997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-DRE-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Danio rerio)
RHEA:66047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-kynurenine <=> (2S)-2-aminobutanoate + H2O + kynurenate
EC:4.1.1.104	skos:prefLabel	"3-dehydro-4-phosphotetronate decarboxylase"
EC:4.1.1.104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydro-4-phosphotetronate decarboxylase"
REACT:R-SSC-5623643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH13 reduces atRAL to atROL (Sus scrofa)
REACT:R-SSC-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Sus scrofa)
RHEA:53931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tertiary amine + S-adenosyl-L-methionine <=> a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-8848338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes TAG (Sus scrofa)
RHEA:31994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquithujene
RHEA:53408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
RHEA:59710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotrionate + H(+) => D-maltotriono-1,5-lactone + H2O
REACT:R-BTA-6799097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates ZNF420 (Bos taurus)
RHEA:59113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine => ADP + H(+) + O-phospho-L-serine
REACT:R-RNO-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Rattus norvegicus)
RHEA:22335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalate <=> 2-methylmaleate + H2O
REACT:R-DME-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Drosophila melanogaster)
REACT:R-DME-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Drosophila melanogaster)
RHEA:66279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tigogenin + UDP-alpha-D-glucose <=> H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP
RHEA:41435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-L-tyrosine + H2O2 <=> 5-hydroxy-3-methyl-L-tyrosine + H2O
REACT:R-MMU-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Mus musculus)
GO:0061776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	topological DNA entrapment activity
GO:0061776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	topological DNA co-entrapment activity
REACT:R-DME-159790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Drosophila melanogaster)
REACT:R-XTR-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Xenopus tropicalis)
REACT:R-DRE-1535903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Danio rerio)
GO:0051748	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PsUSP
GO:0051748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UTP-monosaccharide-1-phosphate uridylyltransferase"
GO:0051748	skos:altLabel	"USP"
GO:0051748	skos:prefLabel	"UTP-monosaccharide-1-phosphate uridylyltransferase"
GO:0051748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-monosaccharide diphosphorylase activity
GO:0051748	skos:altLabel	"UDP-sugar pyrophosphorylase"
GO:0051748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-monosaccharide pyrophosphorylase activity
GO:0051748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP-monosaccharide-1-phosphate uridylyltransferase activity
GO:0051748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monosaccharide 1-phosphate + H(+) + UTP = a UDP-monosaccharide + diphosphate
GO:0051748	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-sugar pyrophosphorylase activity
GO:0051748	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	USP
EC:3.4.16.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxypeptidase C"
EC:3.4.16.5	skos:altLabel	"serine-type carboxypeptidase I"
EC:3.4.16.5	skos:altLabel	"lysosomal protective protein"
EC:3.4.16.5	skos:altLabel	"cathepsin A"
EC:3.4.16.5	skos:altLabel	"carboxypeptidase Y"
EC:3.4.16.5	skos:prefLabel	"carboxypeptidase C"
REACT:R-XTR-1475017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Xenopus tropicalis)
RHEA:67275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)
REACT:R-SSC-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Sus scrofa)
RHEA:40459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 = (2E)-pristenoyl-CoA + H2O2
REACT:R-HSA-8853320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling (Homo sapiens)
REACT:R-XTR-5682858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate H2AFX (Xenopus tropicalis)
REACT:R-DME-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)
REACT:R-GGA-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
REACT:R-DME-209910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is taken up by thyroid epithelial cells (Drosophila melanogaster)
REACT:R-DME-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Drosophila melanogaster)
REACT:R-SSC-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Sus scrofa)
REACT:R-SSC-5607731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)
REACT:R-XTR-391939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP receptor can bind thromboxane (Xenopus tropicalis)
REACT:R-HSA-389970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)
RHEA:31249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prop-2-yn-1-ol + pyrroloquinoline quinone => H(+) + prop-2-ynal + pyrroloquinoline quinol
REACT:R-HSA-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
REACT:R-MMU-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Mus musculus)
RHEA:62387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic (2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-2,3-bisphosphoglycerate + 2 H(+)
REACT:R-DRE-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Danio rerio)
REACT:R-HSA-5693081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) (Homo sapiens)
REACT:R-GGA-6806732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface (Gallus gallus)
RHEA:60391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)
REACT:R-MMU-5334854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAR:RXR binds SUMO-CRABP2:atRA (Mus musculus)
REACT:R-CFA-9707523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to BACH1:MAFK (Canis familiaris)
RHEA:53064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:44740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"27-O-demethylrifamycin SV methyltransferase"
RHEA:44740	skos:prefLabel	"27-O-demethylrifamycin SV methyltransferase"
RHEA:44740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-O-demethylrifamycin SV + S-adenosyl-L-methionine = H(+) + rifamycin SV + S-adenosyl-L-homocysteine
RHEA:23998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-phosphate + diphosphate + H(+) => a ribonucleoside 5'-triphosphate + H2O
REACT:R-DDI-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)
RHEA:57286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA => a guanosine in RNA + methylglyoxal
REACT:R-HSA-5632993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN gene transcription is stimulated by TP53 (Homo sapiens)
REACT:R-PFA-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Plasmodium falciparum)
REACT:R-BTA-8862184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP48 cleaves polyubiquitin (Bos taurus)
REACT:R-DME-4720446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Drosophila melanogaster)
RHEA:11849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine => [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate
REACT:R-HSA-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)
RHEA:38643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)
REACT:R-DME-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Drosophila melanogaster)
REACT:R-HSA-901024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN1B1 hydrolyses 1,2-linked mannose (a branch) (Homo sapiens)
GO:0051751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,4-mannosyltransferase activity
REACT:R-MMU-2395768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPL hydrolyses TGs from mature CMs (Mus musculus)
REACT:R-CFA-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Canis familiaris)
RHEA:63587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxyecdysone 22-phosphate + H2O <=> 2-deoxyecdysone + phosphate
GO:1990135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonoid sulfotransferase activity
REACT:R-CFA-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Canis familiaris)
REACT:R-RNO-451377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IQGAP1 with nephrin (Rattus norvegicus)
RHEA:58544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-tetradecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine
RHEA:54118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + pseudolaratriene => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-DME-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Drosophila melanogaster)
RHEA:23457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + AH2 + O2 => A + crepenynate + 2 H2O
REACT:R-HSA-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Homo sapiens)
RHEA:67192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate
RHEA:66019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + H2O2 <=> H2O + hypobromite
REACT:R-SSC-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Sus scrofa)
RHEA:26013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)
RHEA:21795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propan-2-ol <=> acetone + H(+) + NADPH
REACT:R-GGA-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)
REACT:R-RNO-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Rattus norvegicus)
REACT:R-GGA-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Gallus gallus)
REACT:R-XTR-8863472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAB2 binds LRP2 (Xenopus tropicalis)
RHEA:47537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isochenodeoxycholate + NADP(+)
REACT:R-DRE-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)
RHEA:40460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => (2E)-pristenoyl-CoA + H2O2
RHEA:13139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclolaudenol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine
RHEA:45611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine
REACT:R-DDI-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Dictyostelium discoideum)
REACT:R-HSA-5620918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 dimer binds membrane proteins (Homo sapiens)
REACT:R-SSC-6793661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)
RHEA:46567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + apo-[ACP] <=> acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)
RHEA:42227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + testosterone <=> AH2 + androst-4-ene-3,17-dione
RHEA:46665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + H(+) + NADPH => 5beta-dihydrocorticosterone + NADP(+)
GO:0047106	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-HPAL dehydrogenase activity
GO:0047106	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity
GO:0047106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetaldehyde dehydrogenase activity
REACT:R-HSA-1250346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Homo sapiens)
REACT:R-MMU-416562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGAP binds Plexin-B1 (Mus musculus)
RHEA:16532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + phosphate
RHEA:46085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 1-phosphate => glycerol + phosphate
REACT:R-RNO-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Rattus norvegicus)
REACT:R-MMU-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Mus musculus)
REACT:R-HSA-8857925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
REACT:R-BTA-5357828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8 (Bos taurus)
REACT:R-MMU-422017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase decanoylates Proghrelin (Mus musculus)
REACT:R-BTA-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Bos taurus)
RHEA:17867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,7-dihydropteridine + H(+) + NADPH => 5,6,7,8-tetrahydropteridine + NADP(+)
REACT:R-CFA-6804441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF34 or RFFL ubiquitinates phosphorylated TP53 (Canis familiaris)
REACT:R-CEL-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)
RHEA:39662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-BTA-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Bos taurus)
REACT:R-DDI-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Dictyostelium discoideum)
RHEA:22325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene A4 => leukotriene B4
EC:1.1.1.31	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxyisobutyrate dehydrogenase"
EC:1.1.1.31	skos:prefLabel	"3-hydroxyisobutyrate dehydrogenase"
RHEA:59786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH => H2O + NADP(+) + pseudopaline
REACT:R-BTA-3000103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN:AMN binds CBLIF:RCbl (Bos taurus)
RHEA:18008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threitol + NADP(+) <=> D-erythrulose + H(+) + NADPH
REACT:R-HSA-9033524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves SCP2 (Homo sapiens)
REACT:R-MMU-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Mus musculus)
RHEA:34598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isopentadecanoyl-CoA + L-serine <=> 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA
REACT:R-DME-9009282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates RUNX2 (Drosophila melanogaster)
GO:0097108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hedgehog family protein binding
RHEA:10187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O <=> 3-oxoadipate + H(+)
REACT:R-DRE-936963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization (Danio rerio)
RHEA:45276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-phosphooxy-(9E)-octadecenoate + H2O = 12-hydroxy-(9E)-octadecenoate + phosphate
RHEA:58496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + H(+) + NADH + O2 = glycolaldehyde + H2O + NAD(+) + trimethylamine
REACT:R-HSA-8863007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p25-bound CDK5 phosphorylates CDC25B (Homo sapiens)
REACT:R-GGA-353154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate (Gallus gallus)
RHEA:60138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2
REACT:R-RNO-9733292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind pramlintide (Rattus norvegicus)
RHEA:57211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + L-cysteinyl-[protein] <=> S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]
REACT:R-XTR-417829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds ADP (Xenopus tropicalis)
GO:0097678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	suppressor of cytokine signaling family protein binding
GO:0097678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS family protein binding
REACT:R-DRE-5693564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with RAD52:DNA double-strand break ends (Danio rerio)
GO:0001846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	opsonin binding
RHEA:46641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)
REACT:R-DDI-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)
RHEA:56185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + UDP-alpha-D-galactose => globoside NOR1 + H(+) + UDP
REACT:R-HSA-429699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 binds ceramide (Homo sapiens)
RHEA:36162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]
RHEA:67320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210971
RHEA:72224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) => 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)
REACT:R-MMU-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Mus musculus)
REACT:R-RNO-170070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Rattus norvegicus)
REACT:R-SSC-751027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Sus scrofa)
REACT:R-BTA-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Bos taurus)
REACT:R-PFA-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Plasmodium falciparum)
RHEA:33146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol(in) <=> galactitol(out)
EC:3.2.2.28	skos:prefLabel	"double-stranded uracil-DNA glycosylase"
EC:3.2.2.28	skos:altLabel	"dsUDG"
EC:3.2.2.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"double-stranded uracil-DNA glycosylase"
REACT:R-SSC-6808566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHGA-derived peptide binds the bacterial cell surface (Sus scrofa)
REACT:R-BTA-171059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Bos taurus)
EC:1.4.1.18	skos:altLabel	"LysDH"
EC:1.4.1.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine 6-dehydrogenase"
EC:1.4.1.18	skos:altLabel	"L-lysine epsilon-dehydrogenase"
EC:1.4.1.18	skos:altLabel	"L-lysine 6-dehydrogenase"
EC:1.4.1.18	skos:prefLabel	"lysine 6-dehydrogenase"
RHEA:34744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine 1-phosphate => 13-methyltetradecanal + phosphoethanolamine
GO:0008831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-4-keto-L-rhamnose reductase activity
GO:0008831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH
GO:0008831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-dehydrorhamnose reductase"
GO:0008831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphospho-4-ketorhamnose reductase activity
GO:0008831	skos:altLabel	"dTDP-6-deoxy-L-mannose dehydrogenase"
GO:0008831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydrorhamnose reductase activity
GO:0008831	skos:altLabel	"dTDP-4-keto-L-rhamnose reductase"
GO:0008831	skos:prefLabel	"dTDP-4-dehydrorhamnose reductase"
GO:0008831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, thymidine diphospho-4-ketorhamnose
GO:0008831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-6-deoxy-L-mannose dehydrogenase activity
GO:0008831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-4-ketorhamnose reductase activity
GO:0008831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDP-4-keto-rhamnose reductase activity
GO:0008831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity
RHEA:37329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-methionyl-L-alanine(in) + phosphate => ATP + H2O + L-methionyl-L-alanine(out)
GO:0008687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HPC dioxygenase activity
GO:0008687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)
GO:0008687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoprotocatechuate 2,3-dioxygenase activity
GO:0008687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate 2,3-dioxygenase activity
GO:0008687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity
RHEA:53206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-5218645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 binds p-Y397-PTK2 (Gallus gallus)
REACT:R-SSC-9693324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disulfiram covalently modifies Cys191 in GSDMD (Sus scrofa)
RHEA:21179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH
GO:0002952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO:0002952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-AI-2 isomerase activity
REACT:R-MMU-1676204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Mus musculus)
RHEA:53644	skos:prefLabel	"(+)-corvol ether B synthase"
RHEA:53644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-corvol ether B synthase"
RHEA:53644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate
REACT:R-MMU-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Mus musculus)
RHEA:61814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose
RHEA:28311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
RHEA:12284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + succinate
RHEA:50132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl hexadecanoate + H2O = ethanol + H(+) + hexadecanoate
RHEA:10358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-androstane-3,17-dione + H(+) + NADH => 3alpha-hydroxy-5beta-androstan-17-one + NAD(+)
REACT:R-XTR-8875183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates activated MET (Xenopus tropicalis)
REACT:R-HSA-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Homo sapiens)
REACT:R-MMU-193052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione isomerizes to progesterone (Mus musculus)
RHEA:58809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP + 2 H2O => AMP + GMP + 2 H(+)
REACT:R-GGA-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Gallus gallus)
RHEA:53399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)
RHEA:41607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-BTA-8987080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Bos taurus)
REACT:R-SSC-9648114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 recruits NUDC to mitotic spindle (Sus scrofa)
REACT:R-HSA-379865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)
REACT:R-BTA-5250938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Bos taurus)
REACT:R-GGA-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Gallus gallus)
RHEA:61359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + methotrexate(in) <=> ADP + H(+) + methotrexate(out) + phosphate
REACT:R-DRE-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Danio rerio)
REACT:R-HSA-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Homo sapiens)
REACT:R-GGA-6787737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3R binds CSF3 dimer (Gallus gallus)
RHEA:64834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-benzyl benzoate + CoA => 3-hydroxybenzyl alcohol + benzoyl-CoA
REACT:R-SSC-9696266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds effectors (Sus scrofa)
REACT:R-XTR-5693602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM recognizes H2AFX-Nucleosomes (Xenopus tropicalis)
REACT:R-RNO-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Rattus norvegicus)
REACT:R-MMU-6785933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT8 transfers Gal from UDP-Gal to CERA (Mus musculus)
REACT:R-GGA-443910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 dissociates from integrin alphaIIb beta3 (Gallus gallus)
REACT:R-DDI-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Dictyostelium discoideum)
REACT:R-RNO-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Rattus norvegicus)
REACT:R-HSA-9011983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Homo sapiens)
REACT:R-MMU-2752115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds CD44 (Mus musculus)
RHEA:16870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
RHEA:11564	skos:prefLabel	"cellobionic acid phosphorylase"
RHEA:11564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellobionic acid phosphorylase"
RHEA:11564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-beta-D-glucopyranosyl-D-gluconate + phosphate = alpha-D-glucose 1-phosphate + D-gluconate
REACT:R-HSA-8931648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Homo sapiens)
RHEA:68296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + L-seryl-[protein] = CoA + O-dodecanoyl-L-seryl-[protein]
REACT:R-BTA-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Bos taurus)
GO:0031709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gastrin-releasing peptide receptor binding
GO:0031709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRP receptor binding
GO:0031709	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gastrin-releasing peptide receptor ligand
RHEA:33301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-deoxyhypusine + propane-1,3-diamine => [eIF5A protein]-L-lysine + spermidine
REACT:R-XTR-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Xenopus tropicalis)
RHEA:52882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate
REACT:R-CEL-2327738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Caenorhabditis elegans)
REACT:R-GGA-1227769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex (Gallus gallus)
RHEA:44447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)
REACT:R-RNO-6806974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET dimers autophosphorylate (Rattus norvegicus)
REACT:R-HSA-9647746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 trimerizes (Homo sapiens)
REACT:R-XTR-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Xenopus tropicalis)
RHEA:63412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trichlorophenol + FADH2 + O2 = 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O
REACT:R-HSA-8850992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated PTEN (Homo sapiens)
GO:0003880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein C-terminal carboxyl O-methyltransferase activity
GO:0003880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal protein carboxyl methyltransferase activity
REACT:R-SSC-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Sus scrofa)
RHEA:14698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + NADP(+) => (2E,6E)-farnesal + H(+) + NADPH
RHEA:54450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA + an N-acyl-L-amino acid + H(+) => an N-acyl-L-alpha-aminoacyl-tRNA + H2O
REACT:R-CEL-5205672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncleaved Pink1 accumulates in damaged mitochondria (Caenorhabditis elegans)
REACT:R-GGA-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Gallus gallus)
RHEA:59999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-cinnamate + reduced [electron-transfer flavoprotein]
RHEA:12190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+)
REACT:R-DME-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Drosophila melanogaster)
REACT:R-BTA-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Bos taurus)
REACT:R-RNO-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Rattus norvegicus)
RHEA:23339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O2 + 2 iodide <=> diiodine + 2 H2O
REACT:R-RNO-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)
REACT:R-DRE-2161899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)
REACT:R-HSA-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Homo sapiens)
REACT:R-DRE-5683588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 transfers ATG12 from ATG10 to ATG5 (Danio rerio)
REACT:R-RNO-199202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphopantetheine conjugation of the ACP domain of FAS (Rattus norvegicus)
RHEA:35333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+)
RHEA:40305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenedioyl-CoA + AH2 => A + dodecanedioyl-CoA
REACT:R-DME-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Drosophila melanogaster)
REACT:R-HSA-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)
RHEA:64182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + L-tryptophan => an N-(fatty acyl)-L-tryptophan + H2O
RHEA:58406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanal + NADPH => hexan-1-ol + NADP(+)
REACT:R-XTR-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Xenopus tropicalis)
RHEA:55932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = AMP + H(+) + L-threonyl-[protein]
RHEA:36548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sphinganine => CoA + H(+) + N-(octadecanoyl)-sphinganine
EC:1.14.19.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholesterol 7-desaturase"
EC:1.14.19.21	skos:prefLabel	"cholesterol 7-desaturase"
REACT:R-GGA-177923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sustained activation of SRC kinase by SHP2 (Gallus gallus)
RHEA:21848	skos:prefLabel	"furylfuramide isomerase"
RHEA:21848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"furylfuramide isomerase"
RHEA:21848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide
REACT:R-HSA-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)
RHEA:52123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH => 2,6-dioxo-6-phenylhexanoate + NADP(+)
GO:0106432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	queuosine nucleosidase activity
GO:0106432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	queuosine nucleoside glycosylase
GO:0106432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA queuosine nucleoside glycosylase
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pectate lyase activity
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polygalacturonate lyase activity
GO:0030570	skos:altLabel	"polygalacturonic transeliminase"
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endogalacturonate transeliminase activity
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGA lyase activity
GO:0030570	skos:altLabel	"pectate transeliminase"
GO:0030570	skos:altLabel	"endo-alpha-1,4-polygalacturonic acid lyase"
GO:0030570	skos:altLabel	"pectic lyase"
GO:0030570	skos:altLabel	"endopectin methyltranseliminase"
GO:0030570	skos:altLabel	"polygalacturonate lyase"
GO:0030570	skos:altLabel	"polygalacturonic acid trans-eliminase"
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pectate lyase"
GO:0030570	skos:altLabel	"alpha-1,4-D-endopolygalacturonic acid lyase"
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pectin trans-eliminase activity
GO:0030570	skos:altLabel	"PPase-N"
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPase-N activity
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-alpha-1,4-polygalacturonic acid lyase activity
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polygalacturonic transeliminase activity
GO:0030570	skos:prefLabel	"pectate lyase"
GO:0030570	skos:altLabel	"pectic acid transeliminase"
GO:0030570	skos:altLabel	"PGA lyase"
GO:0030570	skos:altLabel	"pectic acid lyase"
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endopectin methyltranseliminase activity
GO:0030570	skos:altLabel	"polygalacturonic acid lyase"
GO:0030570	skos:altLabel	"endogalacturonate transeliminase"
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectic acid transeliminase activity
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pectic lyase activity
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,4-D-endopolygalacturonic acid lyase activity
GO:0030570	skos:altLabel	"pectin trans-eliminase"
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectic acid lyase activity
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polygalacturonic acid trans-eliminase activity
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1->4)-alpha-D-galacturonan lyase activity
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectate transeliminase activity
GO:0030570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polygalacturonic acid lyase activity
REACT:R-DRE-77345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Danio rerio)
REACT:R-DDI-8850992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated PTEN (Dictyostelium discoideum)
REACT:R-SSC-2002440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen C-propeptides (Sus scrofa)
REACT:R-XTR-5666104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Xenopus tropicalis)
GO:0102742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity
RHEA:33219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-kaurenoic acid monooxygenase"
RHEA:33219	skos:altLabel	"CYP88A3"
RHEA:33219	skos:prefLabel	"ent-kaurenoic acid monooxygenase"
RHEA:33219	skos:altLabel	"ent-kaurenoic acid oxidase"
RHEA:33219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9008479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXW7 polyubiquitinates RUNX2 (Homo sapiens)
RHEA:40190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H2O <=> (3R)-hydroxyoctanoyl-CoA
GO:0018650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	styrene monooxygenase activity
RHEA:26343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionine + Se-methyl-L-selenocysteine => L-selenocysteine + S-methyl-L-methionine
REACT:R-DRE-449087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD4 binds Interleukin-16 (Danio rerio)
REACT:R-DRE-1433488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHP2 by SFKs (Danio rerio)
REACT:R-MMU-372693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
REACT:R-RNO-1067651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Rattus norvegicus)
REACT:R-SSC-5607058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C:PROCR binds F2R (Sus scrofa)
RHEA:41605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
RHEA:51950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase]
GO:0102441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syringetin 7-O-methyltransferase activity
RHEA:19402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol + NAD(+) => formaldehyde + H(+) + NADH
GO:0050086	skos:altLabel	"mannitol dehydrogenase"
GO:0050086	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannitol:NAD+ 2-oxidoreductase activity
GO:0050086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + NAD(+) = D-fructose + H(+) + NADH
GO:0050086	skos:prefLabel	"mannitol 2-dehydrogenase"
GO:0050086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannitol 2-dehydrogenase activity
GO:0050086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannitol 2-dehydrogenase"
GO:0050086	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannitol dehydrogenase activity
RHEA:44308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:50542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin C2 => prostaglandin A2
REACT:R-DME-451819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YKI binds to HTH and TSH and activates transcription (Drosophila melanogaster)
REACT:R-HSA-9657786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the APOD gene (Homo sapiens)
RHEA:19687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-[(E)-feruloyl]tyramine => (E)-feruloyl-CoA + tyramine
REACT:R-GGA-9611721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1-agonists bind ADRB1 (Gallus gallus)
GO:0047176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity
GO:0047176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity
GO:0047176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity
GO:0047176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity
GO:0047176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity
REACT:R-DDI-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Dictyostelium discoideum)
REACT:R-RNO-212642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamine transport into neurons (Rattus norvegicus)
RHEA:60902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine
RHEA:22235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + presqualene diphosphate <=> diphosphate + NADP(+) + squalene
REACT:R-CFA-75872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Canis familiaris)
RHEA:24866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 => 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate
GO:0042124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-beta-glucanosyltransferase activity
GO:0031836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuromedin K receptor binding
GO:0031836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurokinin-B receptor binding
GO:0031836	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neuromedin K receptor ligand
RHEA:50741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene C4 => glycine + leukotriene F4
REACT:R-HSA-933533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of p-IRF7 (Homo sapiens)
REACT:R-SSC-381262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPARG:RXRA heterodimer (ARF6 complex) (Sus scrofa)
RHEA:60199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate
RHEA:18650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O
EC:2.1.1.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase"
EC:2.1.1.14	skos:altLabel	"tetrahydropteroylglutamate-homocysteine transmethylase"
EC:2.1.1.14	skos:altLabel	"cobalamin-independent methionine synthase"
EC:2.1.1.14	skos:altLabel	"homocysteine methylase"
EC:2.1.1.14	skos:altLabel	"methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase"
EC:2.1.1.14	skos:altLabel	"methionine synthase (cobalamin-independent)"
EC:2.1.1.14	skos:prefLabel	"5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase"
REACT:R-CEL-2066299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 binds phosphorylated WWTR1 (TAZ) (Caenorhabditis elegans)
RHEA:61715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine <=> 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine
RHEA:27942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"threo-3-hydroxy-D-aspartate ammonia-lyase"
RHEA:27942	skos:altLabel	"D-threo-3-hydroxyaspartate dehydratase"
RHEA:27942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-D-aspartate = NH4(+) + oxaloacetate
RHEA:27942	skos:prefLabel	"threo-3-hydroxy-D-aspartate ammonia-lyase"
RHEA:48145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine => ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate
RHEA:42942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA precursor + S-adenosyl-L-methionine
RHEA:38934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine
RHEA:35846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin
REACT:R-DDI-5662660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopachrome is transformed to DHICA by DCT (Dictyostelium discoideum)
GO:0055056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose transmembrane transporter activity
REACT:R-HSA-2408529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (Homo sapiens)
REACT:R-CFA-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Canis familiaris)
RHEA:43495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyll a + NADP(+) <=> chlorophyll b + H(+) + NADPH
GO:0010354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate prenyltransferase activity
REACT:R-DDI-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)
REACT:R-SSC-2395818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)
RHEA:41381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene => 4-methylphenol + H2O + NAD(+)
RHEA:38163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
REACT:R-MMU-2130619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosomal vesicle coat assembly (Mus musculus)
GO:0034925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrene 4,5-monooxygenase activity
REACT:R-SPO-5689000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Schizosaccharomyces pombe)
RHEA:60087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADH
RHEA:10480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxy-L-glutamate = 4-hydroxy-2-oxoglutarate + L-glutamate
REACT:R-HSA-9024361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ABCG1 regulated by NR1H2,3 (Homo sapiens)
REACT:R-HSA-874084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IPAF is activated (Homo sapiens)
REACT:R-HSA-5661157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub-SNCA (Homo sapiens)
REACT:R-HSA-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-GGA-4755479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKB2 with SUMO1 (Gallus gallus)
RHEA:42879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine
REACT:R-XTR-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Xenopus tropicalis)
RHEA:11936	skos:prefLabel	"trihydroxystilbene synthase"
RHEA:11936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trihydroxystilbene synthase"
RHEA:11936	skos:altLabel	"resveratrol synthase"
RHEA:11936	skos:altLabel	"stilbene synthase"
RHEA:11936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + trans-resveratrol
RHEA:66800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:16383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-xylulose + NADH => L-arabinitol + NAD(+)
RHEA:25174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-methyl-L-arginine => L-citrulline + methylamine
REACT:R-BTA-2130393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex along Golgi to TGN (Bos taurus)
REACT:R-MMU-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Mus musculus)
REACT:R-CEL-9014812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBOs bind keratan sulfate (Caenorhabditis elegans)
RHEA:57878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(54) in tRNA => uridine(54) in tRNA
RHEA:62773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-phenylalanine => N-acetyl-L-phenylalanine
REACT:R-GGA-419646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:Met (Gallus gallus)
RHEA:17108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-[ACP] + S-adenosyl-L-methionine <=> malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine
REACT:R-RNO-8866304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL binds lipids to form VLDL (Rattus norvegicus)
RHEA:58472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate
RHEA:41089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol
REACT:R-BTA-190256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to FGF (Bos taurus)
REACT:R-HSA-9688838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds STUB1 (Homo sapiens)
RHEA:40775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-phenylacetonitrile + H(+) + 2 H2O = D-alpha-phenylglycine + NH4(+)
RHEA:15796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin IXalpha + NADP(+) <=> biliverdin IXalpha + H(+) + NADPH
REACT:R-MMU-2428926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Mus musculus)
REACT:R-CEL-6804266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TTC5 (Caenorhabditis elegans)
REACT:R-SSC-6804253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates JMY (Sus scrofa)
RHEA:12937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
RHEA:12937	skos:prefLabel	"1-acylglycerophosphocholine O-acyltransferase"
RHEA:12937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-acylglycerophosphocholine O-acyltransferase"
RHEA:12937	skos:altLabel	"lysolecithin acyltransferase"
RHEA:18544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine <=> dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Caenorhabditis elegans)
REACT:R-HSA-5096538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective LFNG does not transfer GlcNAc to Pre-NOTCH (Homo sapiens)
REACT:R-DRE-8871370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Danio rerio)
RHEA:59384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-amino-L-phenylalanine = 3-(4-aminophenyl)pyruvate + L-glutamate
REACT:R-DME-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Drosophila melanogaster)
REACT:R-CEL-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Caenorhabditis elegans)
REACT:R-SSC-179467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Sus scrofa)
RHEA:66266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + nonanoyl-AMP => ATP + H(+) + nonanoate
RHEA:72201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(out) + 2 H(+)(in) => Ca(2+)(in) + 2 H(+)(out)
RHEA:49403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + validoxylamine A 7'-phosphate <=> phosphate + validoxylamine A
REACT:R-MMU-5694431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Mus musculus)
RHEA:25942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-chloroquinolin-2(1H)-one + AH2 => 8-chloroquinoline + A + H2O
REACT:R-DME-2176475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
RHEA:11286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + oxomalonate => hydroxymalonate + NAD(+)
REACT:R-GGA-4088024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Gallus gallus)
GO:0050627	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mycothiol:NAD(P)+ oxidoreductase activity
GO:0050627	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mycothiol-disulfide reductase activity
GO:0050627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycothione reductase activity
GO:0050627	skos:altLabel	"mycothiol-disulfide reductase"
GO:0050627	skos:prefLabel	"mycothione reductase"
GO:0050627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycothione reductase"
REACT:R-HSA-75079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC C complex (Homo sapiens)
RHEA:33308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]
RHEA:19579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + luteolin 7-O-beta-D-glucoside + UDP => luteolin + UDP-alpha-D-glucose
RHEA:45035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome c] + H2O + hydroxylamine <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite
REACT:R-MMU-5627071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Mus musculus)
RHEA:21165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylic ester + H2O => a carboxylate + an alcohol + H(+)
REACT:R-DRE-194642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Danio rerio)
RHEA:14700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + NADP(+) <=> (2E,6E)-farnesal + H(+) + NADPH
REACT:R-MMU-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Mus musculus)
GO:0004591	skos:altLabel	"ketoglutaric dehydrogenase"
GO:0004591	skos:altLabel	"AKGDH"
GO:0004591	skos:altLabel	"oxoglutarate dehydrogenase"
GO:0004591	skos:altLabel	"2-ketoglutarate dehydrogenase"
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutaric dehydrogenase activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxoglutarate dehydrogenase activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
GO:0004591	skos:altLabel	"alpha-ketoglutaric dehydrogenase"
GO:0004591	skos:altLabel	"oxoglutarate dehydrogenase (lipoamide)"
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketoglutaric dehydrogenase activity
GO:0004591	skos:altLabel	"OGDC"
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate: lipoate oxidoreductase activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ketoglutarate dehydrogenase activity
GO:0004591	skos:altLabel	"2-oxoglutarate dehydrogenase"
GO:0004591	skos:altLabel	"alpha-ketoglutaric acid dehydrogenase"
GO:0004591	skos:altLabel	"alpha-ketoglutarate dehydrogenase"
GO:0004591	skos:altLabel	"alpha-oxoglutarate dehydrogenase"
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxoglutarate dehydrogenase (lipoamide) activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxoglutarate dehydrogenase (succinyl-transferring)"
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate dehydrogenase activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-oxoglutarate dehydrogenase activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxoglutarate decarboxylase activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2
GO:0004591	skos:prefLabel	"oxoglutarate dehydrogenase (succinyl-transferring)"
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutaric acid dehydrogenase activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AKGDH activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OGDC activity
GO:0004591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutarate dehydrogenase activity
RHEA:17909	skos:altLabel	"lactate synthase"
RHEA:17909	skos:prefLabel	"lactate aldolase"
RHEA:17909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate = acetaldehyde + formate
RHEA:17909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactate aldolase"
RHEA:17909	skos:altLabel	"(S)-lactate acetaldehyde-lyase"
REACT:R-CFA-9706330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS6 (Canis familiaris)
REACT:R-DME-1236958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of particulate antigens with dendritic cell receptors (Drosophila melanogaster)
RHEA:12275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-dopa <=> CO2 + dopamine
RHEA:39348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)
REACT:R-MMU-1482868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Mus musculus)
REACT:R-CEL-975594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLB1 hydrolyses RPALM to atROL (Caenorhabditis elegans)
RHEA:46799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-RNO-912727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds VAV (Rattus norvegicus)
GO:0034736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:cholesterol O-acyltransferase activity
GO:0034736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:cholesterol acyltransferase activity
GO:0034736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesteryl ester synthetase activity
GO:0034736	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ACAT activity
GO:0034736	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cholesterol acyltransferase activity
GO:0034736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl coenzyme A-cholesterol-O-acyltransferase activity
GO:0034736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol ester synthetase activity
GO:0034736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylcoenzyme A:cholesterol O-acyltransferase activity
GO:0034736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol O-acyltransferase activity
RHEA:12531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate <=> [hyaluronan](n+1) + H(+) + UDP
REACT:R-SSC-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Sus scrofa)
REACT:R-GGA-9604487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7:p-IRF7 translocates to the nucleus (Gallus gallus)
RHEA:55446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Canis familiaris)
RHEA:68663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-BTA-9634850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT (Bos taurus)
RHEA:54731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]
REACT:R-HSA-374207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled estrogen receptor 1 binds estrogen non-classically (Homo sapiens)
REACT:R-SSC-8940959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurolysin degrades neurotensin (Sus scrofa)
RHEA:34588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + pentalenolactone E => CO2 + pentalenolactone F + succinate
RHEA:11942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-ornithine + NH4(+) => 2 H(+) + H2O + L-citrulline
RHEA:13240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + L-glutamine <=> D-glucosamine 6-phosphate + L-glutamate
RHEA:48930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide
REACT:R-RNO-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Rattus norvegicus)
GO:0015192	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-phenylalanine transporter activity
GO:0015192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine transmembrane transporter activity
GO:0015192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine permease activity
REACT:R-DDI-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Dictyostelium discoideum)
RHEA:39938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
REACT:R-DRE-4719447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO1 (Danio rerio)
REACT:R-RNO-9641089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin binds Ub:UBE2N:UBE2V1 (Rattus norvegicus)
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin-TPN reductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin:NADP+ oxidoreductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferredoxin-NADP+ reductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin-NADP oxidoreductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP:ferredoxin oxidoreductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferredoxin-NADP reductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPNH-ferredoxin reductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:ferredoxin oxidoreductase activity
GO:0004324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin-NADP-oxidoreductase activity
REACT:R-SCE-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)
RHEA:39156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O
REACT:R-CFA-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Canis familiaris)
REACT:R-GGA-193656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with RIP2 (Gallus gallus)
REACT:R-XTR-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Xenopus tropicalis)
RHEA:22483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH
REACT:R-DME-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Drosophila melanogaster)
REACT:R-HSA-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)
RHEA:70626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-449976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Sus scrofa)
RHEA:26271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(2+) + precorrin-2 => Co-precorrin-2 + 3 H(+)
REACT:R-DRE-8855131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9 binds Clathrin-coated vesicles (Danio rerio)
RHEA:21105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cholesterol + O2 => 25-hydroxycholesterol + A + H2O
REACT:R-DDI-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Dictyostelium discoideum)
RHEA:65753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-glutamate + O2 => (3R)-3-hydroxy-L-glutamate + CO2 + succinate
REACT:R-RNO-6800315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 binds MST1R (Rattus norvegicus)
RHEA:60414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+) => H2O + monoglucosyl-enterobactin
RHEA:43721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juvenile hormone III carboxylate + S-adenosyl-L-methionine => juvenile hormone III + S-adenosyl-L-homocysteine
REACT:R-MMU-448703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family precursors are cleaved by caspase-1 (Mus musculus)
REACT:R-BTA-8937767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 dephosphorylates RUNX1 (Bos taurus)
RHEA:19520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N-dimethylformamide <=> dimethylamine + formate
REACT:R-SPO-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Schizosaccharomyces pombe)
RHEA:30694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + methanol <=> formaldehyde + 2 H2O
RHEA:70267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(in) + Na(+)(in) = hydrogencarbonate(out) + Na(+)(out)
REACT:R-GGA-5654514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds FGFR1c (Gallus gallus)
RHEA:33323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-SSC-5578966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A:AGO2:miRNA is transported into the nucleus (Sus scrofa)
REACT:R-CFA-9653595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B binds BCL2L1 (Canis familiaris)
REACT:R-CFA-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)
GO:0004137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxycytidine kinase activity
GO:0004137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NTP:deoxycytidine 5'-phosphotransferase activity
GO:0004137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ara-C kinase activity
GO:0004137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidine kinase (phosphorylating)
GO:0004137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidine-cytidine kinase activity
GO:0004137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine kinase activity
GO:0004137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arabinofuranosylcytosine kinase activity
GO:0001855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C4b binding
RHEA:18327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-amorpha-4,11-diene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-MMU-9020275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DHA to 17(S)-Hp-DHA (Mus musculus)
REACT:R-CEL-391375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Caenorhabditis elegans)
RHEA:36297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + phosphate => alpha-maltose 6'-phosphate + H2O
RHEA:27342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + NH4(+) + O2 => A + H(+) + H2O + hydroxylamine
REACT:R-RNO-8985914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Rattus norvegicus)
REACT:R-MMU-5683588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 transfers ATG12 from ATG10 to ATG5 (Mus musculus)
GO:0008672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxyglucarate aldolase activity
GO:0008672	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxyglucarate aldolase activity
GO:0008672	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-keto-beta-deoxy-D-glucarate aldolase activity
GO:0008672	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)
GO:0008672	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity
REACT:R-HSA-399946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of Cdk5 (Homo sapiens)
REACT:R-HSA-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
REACT:R-CFA-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Canis familiaris)
REACT:R-RNO-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Rattus norvegicus)
REACT:R-SSC-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Sus scrofa)
GO:0090584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-galactitol-phosphotransferase system transporter activity
RHEA:41026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA
REACT:R-HSA-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Homo sapiens)
REACT:R-MMU-5653886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1 binds LALBA (Mus musculus)
RHEA:44343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + ATP + fumarate <=> AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate
RHEA:22916	skos:prefLabel	"4-hydroxyacetophenone monooxygenase"
RHEA:22916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyacetophenone monooxygenase"
RHEA:22916	skos:altLabel	"HAPMO"
RHEA:22916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-hydroxyacetophenone + H(+) + NADPH + O2 = 4-acetoxyphenol + H2O + NADP(+)
RHEA:66968	skos:prefLabel	"GDP-Man:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-mannosyltransferase"
RHEA:66968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
RHEA:66968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-Man:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-mannosyltransferase"
REACT:R-XTR-9714924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to soluble TNF trimer (Xenopus tropicalis)
REACT:R-SSC-5324617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:FKBP4:PTGES3 binds HSF1 trimer (Sus scrofa)
REACT:R-HSA-6814094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds ARFIP2 (Homo sapiens)
RHEA:28019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin + 3 H2O => 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine
RHEA:67041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) => asnovolin H
REACT:R-DME-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Drosophila melanogaster)
REACT:R-RNO-163096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Telomerase RNP to the Telomeric Chromosome End (Rattus norvegicus)
RHEA:56461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine
GO:0071207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone pre-mRNA stem-loop binding
REACT:R-CFA-8944220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIII (Canis familiaris)
REACT:R-SSC-888577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GABA by GAD2 (Sus scrofa)
REACT:R-DRE-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Danio rerio)
REACT:R-HSA-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Homo sapiens)
REACT:R-GGA-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Gallus gallus)
REACT:R-MMU-209792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylation of serotonin (Mus musculus)
REACT:R-RNO-8851929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Rattus norvegicus)
REACT:R-RNO-77587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Replication Dependent Histone mRNA with the NPC (Rattus norvegicus)
REACT:R-RNO-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Rattus norvegicus)
REACT:R-BTA-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Bos taurus)
REACT:R-DRE-6807206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)
GO:0080019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acyl-CoA reductase (alcohol-forming) activity
GO:0080019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acyl CoA reductase (alcohol-forming) activity
GO:0080019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acyl-CoA reductase (alcohol-forming) activity
RHEA:52936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O = (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]
REACT:R-XTR-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Xenopus tropicalis)
REACT:R-DRE-4755478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates IKBKE with SUMO1 (Danio rerio)
REACT:R-DME-190429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c (Drosophila melanogaster)
REACT:R-CEL-432164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)
RHEA:36201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-HSA-3322016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Homo sapiens)
REACT:R-DRE-8956458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNLS:FAD oxidises dh-beta-NAD to NAD+ (Danio rerio)
REACT:R-RNO-5658435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs bind RAS:GTP (Rattus norvegicus)
REACT:R-MMU-199443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Mus musculus)
RHEA:68147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl 3-oxobutanoate + H(+) + NADPH <=> ethyl (R)-3-hydroxybutanoate + NADP(+)
RHEA:14131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)
REACT:R-DRE-71541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Danio rerio)
RHEA:23335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GTP <=> (2R)-3-phospho-glyceroyl phosphate + GDP
REACT:R-HSA-9626880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Homo sapiens)
REACT:R-GGA-9691174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the ER membrane (Gallus gallus)
RHEA:21035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronate acceptor + UDP-alpha-D-glucuronate <=> acceptor beta-D-glucuronoside + H(+) + UDP
RHEA:39710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA(out) <=> a long-chain fatty acyl-CoA(in)
GO:0005167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotrophin TRK receptor binding
GO:0005167	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin TRK receptor ligand
REACT:R-DDI-428262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Dictyostelium discoideum)
REACT:R-XTR-417825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y11 receptor can bind to ATP (Xenopus tropicalis)
REACT:R-CFA-2424477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:GTP 3'-diphosphotransferase activity
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine pentaphosphate synthetase activity
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP pyrophosphokinase activity
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPSII
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5',3'-polyphosphate synthetase activity
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-GTP 3'-diphosphotransferase activity
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ppGpp synthetase I activity
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(p)ppGpp synthetase II
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 3',5'-polyphosphate synthase activity
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPSI
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP diphosphokinase activity
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(p)ppGpp synthetase I
GO:0008728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	stringent factor activity
GO:0001852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component iC3b binding
GO:0050474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-norcoclaurine synthase activity
GO:0050474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)
GO:0050474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]
GO:0050474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-norlaudanosoline synthase activity
REACT:R-HSA-2130336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)
REACT:R-MMU-8944240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type III (Mus musculus)
REACT:R-DRE-8852809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPN, CPB2 cleave C3a, C5a (Danio rerio)
RHEA:40734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + 2 H2O <=> (20S)-protopanaxadiol + 2 D-glucose
REACT:R-HSA-4655355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)
REACT:R-HSA-8953398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIR oxygenates quercetin (Homo sapiens)
RHEA:63916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-fluorouridine + ATP = 5-fluorouridine 5'-phosphate + ADP + H(+)
RHEA:55854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA
REACT:R-HSA-9628758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 G83D does not cleave FapyG (Homo sapiens)
RHEA:45229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3E)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA
REACT:R-DRE-1602368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Danio rerio)
RHEA:17612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine
RHEA:35868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA
REACT:R-HSA-532678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase (Homo sapiens)
REACT:R-SSC-9638075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from DS (Sus scrofa)
REACT:R-HSA-2395328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP1, LTBP3 bind TGF-Beta (Homo sapiens)
REACT:R-GGA-201810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ligand trap binds the ligand BMP2, blocking BMP signalling (Gallus gallus)
REACT:R-RNO-447252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB1:TYK2 binds IL12RB2:JAK2 (Rattus norvegicus)
REACT:R-MMU-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-MMU-9014641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Mus musculus)
REACT:R-SPO-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Schizosaccharomyces pombe)
REACT:R-SSC-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Sus scrofa)
REACT:R-DME-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Drosophila melanogaster)
REACT:R-RNO-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Rattus norvegicus)
RHEA:51526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	magnoflorine + S-adenosyl-L-homocysteine => (S)-corytuberine + S-adenosyl-L-methionine
RHEA:66123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-methionine <=> (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate
EC:3.4.21.37	skos:altLabel	"lysosomal elastase"
EC:3.4.21.37	skos:prefLabel	"leukocyte elastase"
EC:3.4.21.37	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leukocyte elastase"
EC:3.4.21.37	skos:altLabel	"neutrophil elastase"
EC:3.4.21.37	skos:altLabel	"medullasin"
EC:3.4.21.37	skos:altLabel	"bone marrow serine protease"
RHEA:64737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxynonanal + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH
REACT:R-MMU-9029667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DFF dissociates from importin-alpha:importin-beta (Mus musculus)
GO:0030942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER signal peptide binding
GO:0030942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoplasmic reticulum signal peptide binding
REACT:R-GGA-173636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of classic pathway C5 convertase (Gallus gallus)
REACT:R-CFA-6814678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Canis familiaris)
REACT:R-SSC-198813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO dimers reduce DeHA to AscH- (Sus scrofa)
REACT:R-CFA-75825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of Cyclin D1 (Canis familiaris)
REACT:R-DRE-8848663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADIPOQ trimer binds ADIPOR dimers (Danio rerio)
RHEA:53568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-446868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Interleukin 1 receptor complex binds Tollip (Bos taurus)
REACT:R-CFA-1861621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIA with IgG-coated Ag (Canis familiaris)
REACT:R-XTR-2984220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1:CCNB phosphorylates NEK9 (Xenopus tropicalis)
REACT:R-DDI-5603114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Dictyostelium discoideum)
REACT:R-RNO-193407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
REACT:R-SSC-5671763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates PPP1R14A (Sus scrofa)
REACT:R-CFA-421426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ProGIP translocates from the ER Lumen to secretory granules (Canis familiaris)
RHEA:67692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + hexadecanedioate(in) = ADP + H(+) + hexadecanedioate(out) + phosphate
REACT:R-MMU-8983298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)
REACT:R-SPO-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Schizosaccharomyces pombe)
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2,4-diaminobutanoate acetyltransferase activity
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diaminobutyric acid acetyltransferase activity
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4-diaminobutanoate acetyltransferase activity
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	EctA
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diaminobutyrate acetyltransferase activity
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAB acetyltransferase activity
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DABAcT
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DABA acetyltransferase activity
GO:0033816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2,4-diaminobutyrate acetyltransferase activity
REACT:R-CFA-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Canis familiaris)
REACT:R-SCE-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Saccharomyces cerevisiae)
REACT:R-SSC-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Sus scrofa)
REACT:R-BTA-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Bos taurus)
GO:1990224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinamide D-riboside + phosphate
GO:1990224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide mononucleotide phosphatase activity
GO:1990224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMN phosphatase activity
GO:1990224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide phosphatase activity
RHEA:23532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholate + CoA = AMP + choloyl-CoA + diphosphate
REACT:R-CFA-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Canis familiaris)
RHEA:56906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + an acyl-CoA + H(+) => an acyl-AMP + CoA
GO:0018031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-lysine N6-palmitoyltransferase activity
RHEA:69853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in mRNA + H(+) + NADH => a 5,6-dihydrouridine in mRNA + NAD(+)
RHEA:13094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP
REACT:R-HSA-193812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Efflux of 27-hydroxycholesterol (Homo sapiens)
RHEA:33079	skos:altLabel	"aminofutalosine nucleosidase"
RHEA:33079	skos:prefLabel	"aminodeoxyfutalosine nucleosidase"
RHEA:33079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminodeoxyfutalosine nucleosidase"
RHEA:33079	skos:altLabel	"AFL nucleosidase"
RHEA:33079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-6-deoxyfutalosine + H2O = adenine + dehypoxanthine futalosine
RHEA:33079	skos:altLabel	"methylthioadenosine nucleosidase"
REACT:R-DDI-9026911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Dictyostelium discoideum)
RHEA:40621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+) => H2O + tridodecanoylglycerol
REACT:R-XTR-111238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR2  homodimer (Xenopus tropicalis)
REACT:R-GGA-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Gallus gallus)
EC:3.2.1.20	skos:altLabel	"glucosidosucrase"
EC:3.2.1.20	skos:prefLabel	"alpha-glucosidase"
EC:3.2.1.20	skos:altLabel	"maltase-glucoamylase"
EC:3.2.1.20	skos:altLabel	"lysosomal alpha-glucosidase"
EC:3.2.1.20	skos:altLabel	"glucoinvertase"
EC:3.2.1.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-glucosidase"
EC:3.2.1.20	skos:altLabel	"acid maltase"
EC:3.2.1.20	skos:altLabel	"maltase"
REACT:R-HSA-9717182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP and GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)
REACT:R-DME-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Drosophila melanogaster)
RHEA:16627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + thioacetate => acetyl-CoA + hydrogen sulfide
REACT:R-HSA-2509816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses IDP to IMP (Homo sapiens)
RHEA:65373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer => CMP + globoside MSGG + H(+)
REACT:R-CEL-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Caenorhabditis elegans)
RHEA:26252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + levopimaradienol + NADPH + O2 <=> 2 H2O + levopimaradienal + NADP(+)
REACT:R-GGA-421454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of protoporphyrin IX from the mitochondrial intermembrane space into the mitochondrial matrix (Gallus gallus)
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminomalonic decarboxylase activity
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate omega-decarboxylase activity
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate 4-decarboxylase activity
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine sulfinic desulfinase activity
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic beta-decarboxylase activity
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine sulfinate acid desulfinase activity
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate 4-carboxy-lyase (L-alanine-forming)
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate beta-decarboxylase activity
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desulfinase activity
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate 4-carboxy-lyase activity
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic omega-decarboxylase activity
GO:0047688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate beta-decarboxylase activity
REACT:R-XTR-170055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Xenopus tropicalis)
GO:0102917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline 7-O-methyltransferase activity
RHEA:58690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide => NADH + O2 + rifamycin SV
REACT:R-HSA-9705726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed (Homo sapiens)
REACT:R-CFA-392051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Grb2 to pFAK:NCAM1 (Canis familiaris)
REACT:R-DME-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Drosophila melanogaster)
REACT:R-HSA-8870289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PUS3 transforms uridine-39 to pseudouridine-39 in tRNA (Homo sapiens)
REACT:R-DRE-5578777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMPK phosphorylates PLN (Danio rerio)
REACT:R-CEL-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Caenorhabditis elegans)
RHEA:20444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + O2 <=> 3-sulfino-L-alanine + H(+)
RHEA:25723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:57090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+) => an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O
REACT:R-HSA-211239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with chromatin (Homo sapiens)
REACT:R-BTA-5623513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 stimulates GTPase activity of ARF4 (Bos taurus)
RHEA:18675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[receptor-protein] => ATP + L-seryl-[receptor-protein]
REACT:R-SPO-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Schizosaccharomyces pombe)
REACT:R-SSC-8950504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27 binds CRLF1 (Sus scrofa)
RHEA:48112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-XTR-73718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBF-1 Binds rDNA Promoter (Xenopus tropicalis)
RHEA:68007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chloroethene <=> A + chloride + ethene + H(+)
RHEA:70540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] => 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)
RHEA:17228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-SSC-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Sus scrofa)
REACT:R-CFA-8963851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 dissociates from GC (Canis familiaris)
REACT:R-RNO-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Rattus norvegicus)
GO:0015299	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity
GO:0015299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:proton antiporter activity
GO:0015299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:hydrogen antiporter activity
GO:0015299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Homo sapiens)
REACT:R-XTR-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Xenopus tropicalis)
RHEA:21159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate + H2O <=> (R)-glycerate + phosphate
RHEA:31350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-abscisic acid D-glucopyranosyl ester + H2O <=> 2-cis-(+)-abscisate + beta-D-glucose + H(+)
RHEA:14157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triphosphate = diphosphate + phosphate
RHEA:14157	skos:prefLabel	"triphosphatase"
RHEA:14157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"triphosphatase"
RHEA:14243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+) => 3-amino-4-hydroxybenzaldehyde + acetyl-CoA
GO:0034701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tripeptidase activity
REACT:R-HSA-163820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Homo sapiens)
REACT:R-RNO-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Rattus norvegicus)
RHEA:23860	skos:altLabel	"CPC acetylhydrolase"
RHEA:23860	skos:altLabel	"DAC-AT"
RHEA:23860	skos:altLabel	"deacetylcephalosporin C acetyltransferase"
RHEA:23860	skos:altLabel	"acetyl-CoA:DAC acetyltransferase"
RHEA:23860	skos:prefLabel	"deacetylcephalosporin-C acetyltransferase"
RHEA:23860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA
RHEA:23860	skos:altLabel	"acetyl coenzyme A:DAC acetyltransferase"
RHEA:23860	skos:altLabel	"DAC acetyltransferase"
RHEA:23860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deacetylcephalosporin-C acetyltransferase"
REACT:R-GGA-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)
REACT:R-HSA-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Homo sapiens)
REACT:R-BTA-6807144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Bos taurus)
RHEA:24665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide
REACT:R-DME-3788725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C complex binds EHMT1:EHMT2 (Drosophila melanogaster)
GO:0102319	skos:prefLabel	"2-deoxystreptamine N-acetyl-D-glucosaminyltransferase"
GO:0102319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-deoxystreptamine N-acetyl-D-glucosaminyltransferase"
GO:0102319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine = 2'-N-acetylparomamine + H(+) + UDP
GO:0102319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity
REACT:R-HSA-209891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine is oxidised to noradrenaline (Homo sapiens)
REACT:R-HSA-9624272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMPs cleave HB-EGF (Homo sapiens)
RHEA:35180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA => 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone
REACT:R-CFA-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Canis familiaris)
REACT:R-MMU-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Mus musculus)
RHEA:68538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-alpha-cedrene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-PFA-4570485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO3 (Plasmodium falciparum)
REACT:R-XTR-199404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40L binds CD40 (Xenopus tropicalis)
REACT:R-HSA-443778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of L1 with Laminin-1 (Homo sapiens)
REACT:R-CEL-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Caenorhabditis elegans)
REACT:R-DDI-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Dictyostelium discoideum)
REACT:R-CEL-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Caenorhabditis elegans)
REACT:R-MMU-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Mus musculus)
REACT:R-CFA-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Canis familiaris)
REACT:R-MMU-9603302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (peptide) binds IIa (Mus musculus)
REACT:R-HSA-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Homo sapiens)
RHEA:70796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-lysine(out) => H(+)(out) + L-lysine(in)
REACT:R-BTA-428909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-protein  G13 (Bos taurus)
RHEA:67462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + oxaloacetate => (R)-malate + A
REACT:R-MMU-5654729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Mus musculus)
RHEA:42187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH
REACT:R-HSA-873926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNGR (Homo sapiens)
RHEA:38602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + nicotinate <=> nicotinamide + nicotinate-adenine dinucleotide phosphate
GO:0047073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)
GO:0047073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(4-hydroxybenzoyl)methanol oxygenase activity
GO:0047073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4'-dihydroxyacetophenone dioxygenase activity
RHEA:60472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
REACT:R-HSA-390402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol (Homo sapiens)
RHEA:40785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + docosanoate + H(+) => docosanoyl-CoA + H2O
GO:0120294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)
GO:0120294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide serotonyltransferase activity
RHEA:72778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-carboxymellein + ATP + L-phenylalanine <=> ADP + H(+) + ochratoxin B + phosphate
REACT:R-HSA-8876731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEST translocates from ER membrane to lipid particle (Homo sapiens)
RHEA:42483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)
REACT:R-MMU-3371385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α is cleaved by ADAM17 (TACE) (Mus musculus)
RHEA:43051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagatose <=> keto-D-sorbose
RHEA:51261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:52771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O <=> 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate
REACT:R-CFA-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Canis familiaris)
REACT:R-RNO-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)
REACT:R-MMU-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Mus musculus)
REACT:R-RNO-933536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7 dimer interacts with coactivator CBP/p300 (Rattus norvegicus)
REACT:R-BTA-8849646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK5(490-624) binds KLK5 (Bos taurus)
RHEA:37382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-HSA-5626988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds NSMAF (Homo sapiens)
RHEA:43498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-fructuronate + NADH => L-gulonate + NAD(+)
RHEA:32894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S)-alpha-pinene + H(+) + NADH + O2 <=> alpha-pinene oxide + H2O + NAD(+)
REACT:R-DME-6801776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A binds bacterial phospholipids (Drosophila melanogaster)
REACT:R-SCE-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Saccharomyces cerevisiae)
RHEA:13675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein-PII]-uridylyl-L-tyrosine + diphosphate => [protein-PII]-L-tyrosine + UTP
REACT:R-BTA-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Bos taurus)
REACT:R-HSA-2533874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminin-511 degradation by MMP14 (Homo sapiens)
REACT:R-DME-1168642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Drosophila melanogaster)
RHEA:44939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate
RHEA:16742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA
REACT:R-GGA-8939201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR dimerizes (Gallus gallus)
RHEA:14035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1-phosphate + glycerol + H(+) => H2O + sn-glycero-3-phospho-1D-myo-inositol
REACT:R-BTA-9652580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Bos taurus)
REACT:R-BTA-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Bos taurus)
RHEA:26292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine <=> 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate
RHEA:49417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-ribose 1-phosphate => alpha-D-ribose 1,5-bisphosphate + AMP + H(+)
REACT:R-BTA-1605591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Bos taurus)
REACT:R-CEL-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Caenorhabditis elegans)
RHEA:20785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(ADP-D-ribosyl)-L-arginine => ADP-D-ribose + L-arginine
RHEA:53222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:34314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol + NADH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite
RHEA:55220	skos:altLabel	"methylsterol hydroxylase"
RHEA:55220	skos:altLabel	"4-methylsterol oxidase"
RHEA:55220	skos:altLabel	"methylsterol monooxygenase"
RHEA:55220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4alpha-methylsterol monooxygenase"
RHEA:55220	skos:prefLabel	"4alpha-methylsterol monooxygenase"
RHEA:55220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-HSA-5653974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator binds Rag dimers (Homo sapiens)
REACT:R-SCE-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Saccharomyces cerevisiae)
REACT:R-CEL-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
REACT:R-MMU-8853753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Mus musculus)
REACT:R-SSC-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Sus scrofa)
RHEA:43613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(341) in tmRNA => 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Gallus gallus)
REACT:R-DRE-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Danio rerio)
RHEA:59043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:24231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> 4-methylcatechol + CO2 + NADH
RHEA:67643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dZMP <=> ADP + dZDP
RHEA:17849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybutyryl-CoA dehydratase"
RHEA:17849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O
RHEA:17849	skos:prefLabel	"3-hydroxybutyryl-CoA dehydratase"
RHEA:17849	skos:altLabel	"crotonase"
REACT:R-MMU-5676596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds BAFFR:BAFF (Mus musculus)
RHEA:62855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-HSA-548815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Homo sapiens)
REACT:R-DRE-427527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC dimethylates histone H3 at lysine-9 (Danio rerio)
REACT:R-DME-170131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Drosophila melanogaster)
RHEA:15744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) <=> 2,5-dichlorohydroquinone + H(+) + NADH
RHEA:37275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-glutamine = L-alanine + L-glutamine
RHEA:23215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-alanine <=> acetate + beta-alanine
GO:0070025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binding
GO:0070025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon monoxide binding
REACT:R-RNO-5218952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)
RHEA:58661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine
REACT:R-HSA-8864569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds TFAP2C (Homo sapiens)
REACT:R-HSA-9688459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds HSP90:CDC37 (Homo sapiens)
RHEA:65115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + aculene D + O2 <=> aculene C + CO2 + H2O + succinate
RHEA:45076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:1902485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine binding
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol 3-phosphate acyltransferase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphate transacylase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-glycerophosphate acyltransferase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glycerophosphate acyltransferase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycerol 3-phosphate acyltransferase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol phosphate acyltransferase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycerol-3-phosphate acyltransferase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate O-acyltransferase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphate acyltransferase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol phosphate transacylase activity
GO:0004366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACP:sn-glycerol-3-phosphate acyltransferase activity
REACT:R-CFA-2318623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan binds Hyaluronan and HAPLN1 (Canis familiaris)
REACT:R-BTA-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Bos taurus)
REACT:R-GGA-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Gallus gallus)
REACT:R-CEL-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Caenorhabditis elegans)
REACT:R-XTR-110232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by MBD4 glycosylase (Xenopus tropicalis)
RHEA:25800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine
REACT:R-HSA-446634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 is activated by autophosphorylation (Homo sapiens)
REACT:R-RNO-198613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)
REACT:R-XTR-2046285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The keratan chain can be capped by N-acetylneuraminic acid (Xenopus tropicalis)
RHEA:40392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA => 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA
REACT:R-CFA-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Canis familiaris)
RHEA:43804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol
GO:0033752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Dke1
GO:0033752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylacetone dioxygenase activity
GO:0033752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diketone cleaving enzyme
GO:0033752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diketone cleaving dioxygenase activity
GO:0033752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylacetone-cleaving enzyme
GO:0033752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylacetone-cleaving enzyme activity
GO:0033752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylacetone:oxygen oxidoreductase activity
RHEA:23414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + putrescine => H2O + N-acetylputrescine
EC:2.4.1.181	skos:prefLabel	"hydroxyanthraquinone glucosyltransferase"
EC:2.4.1.181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyanthraquinone glucosyltransferase"
REACT:R-HSA-913374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits SHIP (Homo sapiens)
RHEA:31175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl-CoA
GO:0102345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-lignoceroyl-CoA dehydratase activity
RHEA:49584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose 1-phosphate = L-erythrulose 1-phosphate
RHEA:49584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-erythrulose 1-phosphate 3-epimerase"
RHEA:49584	skos:prefLabel	"D-erythrulose 1-phosphate 3-epimerase"
REACT:R-DRE-420127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGRP receptor can bind calcitonin gene-related peptides (Danio rerio)
GO:0016454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-palmitoyltransferase activity
RHEA:11006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + salicylate
RHEA:31763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid
RHEA:31763	skos:prefLabel	"methionine transaminase"
RHEA:31763	skos:altLabel	"methionine-oxo-acid transaminase"
RHEA:31763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionine transaminase"
REACT:R-BTA-2046180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSPG is secreted from the cell (Bos taurus)
RHEA:55870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + pyruvate => (S)-lactate + O2
RHEA:40688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol => 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-CFA-73815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
RHEA:68093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA => a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)
REACT:R-HSA-173720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7 translocates to the plasma membrane (Homo sapiens)
REACT:R-SSC-5626228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The distal appendage proteins recruit TTBK2 (Sus scrofa)
REACT:R-GGA-5672972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
REACT:R-DRE-8942344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 transports FOLA from extracellular region to cytosol (Danio rerio)
RHEA:17933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoflavone 7-O-methyltransferase"
RHEA:17933	skos:prefLabel	"isoflavone 7-O-methyltransferase"
RHEA:17933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-hydroxyisoflavone + S-adenosyl-L-methionine = a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)
RHEA:34382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP
REACT:R-HSA-9029517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Homo sapiens)
GO:0004897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gp130
GO:0004897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ciliary neurotrophic factor receptor activity
GO:0004897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNTF receptor activity
REACT:R-MMU-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Mus musculus)
RHEA:63992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-fluorocytidine + ATP = 5-fluorocytidine 5'-phosphate + ADP + H(+)
REACT:R-DDI-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Dictyostelium discoideum)
REACT:R-CFA-264615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Canis familiaris)
GO:1990650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity
RHEA:57856	skos:prefLabel	"feruloyl-CoA 6-hydroxylase"
RHEA:57856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"feruloyl-CoA 6-hydroxylase"
RHEA:57856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + 2-oxoglutarate + O2 = (E)-6-hydroxyferuloyl-CoA + CO2 + succinate
REACT:R-BTA-9733545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids bind ALB (Bos taurus)
RHEA:22730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-selenocysteinyl-tRNA(Sec) + phosphate => H(+) + L-seryl-tRNA(Sec) + selenophosphate
RHEA:43018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + an alkyl thiol => an S-alkyl-L-cysteine
RHEA:58016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Canis familiaris)
REACT:R-DRE-5683888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMCD1 binds GATA6, sequestering it (Danio rerio)
REACT:R-DRE-190268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to Klotho-bound FGF23 (Danio rerio)
REACT:R-CFA-168140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Canis familiaris)
REACT:R-HSA-5662608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds cadmium (Homo sapiens)
REACT:R-MMU-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Mus musculus)
RHEA:43099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:46238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:0000150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RecA-family recombinase activity
GO:0000150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA strand exchange activity
GO:0000150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	strand exchange activity
GO:0000150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	recombinase activity
GO:0000150	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	strand transferase
GO:0000150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of meiotic heteroduplex (Homo sapiens)
REACT:R-XTR-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Xenopus tropicalis)
RHEA:71466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P <=> Gly-L-Leu-L-Met-NH2 + substance P(1-8)
RHEA:65073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => dauca-4,7-diene + diphosphate
RHEA:72174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurohyocholate(out) <=> 2 Na(+)(in) + taurohyocholate(in)
RHEA:61549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:45911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroorienticin B + dTDP-beta-L-vancosamine <=> chloroeremomycin + dTDP + H(+)
REACT:R-SSC-5654169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 (Sus scrofa)
RHEA:55466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:55650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + succinate + validoxylamine B => 2-oxoglutarate + O2 + validoxylamine A
RHEA:22571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascopyrone M <=> ascopyrone P
REACT:R-CEL-450257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Caenorhabditis elegans)
REACT:R-SSC-203625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOSTRIN mediated translocation of eNOS from plasma membrane (Sus scrofa)
REACT:R-BTA-6786101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4 binds IL4R:JAK2 (Bos taurus)
REACT:R-HSA-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Homo sapiens)
REACT:R-MMU-2161775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12 oxidises LTA4 to LXA4/B4 (Mus musculus)
REACT:R-SPO-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Schizosaccharomyces pombe)
RHEA:22134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-maltose(in) + H(+) + phosphate => ATP + D-maltose(out) + H2O
RHEA:24933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + NH4(+) + pyruvate => H2O + L-cysteine
RHEA:57724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate
RHEA:57724	skos:prefLabel	"oxaloacetate decarboxylase (Na(+) extruding)"
RHEA:57724	skos:altLabel	"oxalacetic acid decarboxylase"
RHEA:57724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxaloacetate decarboxylase (Na(+) extruding)"
RHEA:57724	skos:altLabel	"oxaloacetate beta-decarboxylase"
RHEA:57724	skos:altLabel	"oxalate beta-decarboxylase"
RHEA:21299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + NAD(+) <=> D-galactono-1,4-lactone + H(+) + NADH
REACT:R-DDI-5662662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosinase oxidises tyrosine to dopaquinone (Dictyostelium discoideum)
REACT:R-PFA-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)
RHEA:24441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphate(out) => ADP + H(+) + 2 phosphate(in)
REACT:R-HSA-375339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Homo sapiens)
GO:0102967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxygeraniol oxidoreductase activity
RHEA:51627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + GTP + H(+) <=> CO2 + dGTP + H2O
GO:0047872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichol O-acyltransferase activity
GO:0047872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl-CoA:dolichol O-palmitoyltransferase activity
GO:0047872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:dolichol acyltransferase activity
RHEA:14421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-benzoyl-D-arginine-4-nitroanilide = 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine
RHEA:14421	skos:prefLabel	"D-benzoylarginine-4-nitroanilide amidase"
RHEA:14421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-benzoylarginine-4-nitroanilide amidase"
REACT:R-DME-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Drosophila melanogaster)
REACT:R-HSA-8871226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA2 (Homo sapiens)
RHEA:68522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-acoradiene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-RNO-163090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation Of The Telomeric Chromosome End (Rattus norvegicus)
REACT:R-HSA-9665703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 TMD/JMD mutants bind pertuzumab (Homo sapiens)
RHEA:56062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + pentadecane => H(+) + hexadecanoate + hnu
REACT:R-RNO-5684868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPC translocates from ER membrane to multivesicle body (Rattus norvegicus)
RHEA:10723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione
REACT:R-BTA-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Bos taurus)
GO:0099130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrogen binding
REACT:R-DDI-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Dictyostelium discoideum)
REACT:R-DME-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Drosophila melanogaster)
RHEA:56482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2
RHEA:13866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)
REACT:R-GGA-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Gallus gallus)
REACT:R-HSA-9013895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 processing within TLR3 complex (Homo sapiens)
RHEA:26213	skos:prefLabel	"aphidicolan-16beta-ol synthase"
RHEA:26213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aphidicolan-16beta-ol synthase"
RHEA:26213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate
RHEA:26213	skos:altLabel	"ACS"
REACT:R-BTA-9749197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 binds to H4K20me2 (Bos taurus)
REACT:R-CFA-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Canis familiaris)
RHEA:70747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
RHEA:66120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-methionine = (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate
GO:0000006	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	high-affinity zinc uptake transmembrane transporter activity
GO:0000006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity zinc transmembrane transporter activity
GO:0000006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity zinc uptake transmembrane transporter activity
GO:0042578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoric ester hydrolase activity
REACT:R-MMU-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Mus musculus)
RHEA:21293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)
RHEA:41651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aniline + ATP + L-glutamate <=> ADP + N(5)-phenyl-L-glutamine + phosphate
RHEA:67260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hept-2-enal + H2O + NAD(+) = (E)-hept-2-enoate + 2 H(+) + NADH
RHEA:49853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-octenoyl-CoA => (2E)-octenoyl-CoA
REACT:R-RNO-9625482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated EGFR (Rattus norvegicus)
REACT:R-DDI-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)
REACT:R-CEL-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:19043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:55240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)
REACT:R-GGA-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Gallus gallus)
REACT:R-GGA-9664855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Gallus gallus)
RHEA:57298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O
REACT:R-HSA-1168423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation of IRS-1/2 (Homo sapiens)
RHEA:50751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juglone <=> naphthalene-1,2,4,8-tetrol
REACT:R-CFA-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
RHEA:50123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-taurine
REACT:R-MMU-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Mus musculus)
RHEA:39250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z)-eicosenoyl-CoA <=> (2E,11Z)-eicosadienoyl-CoA + H2O
REACT:R-HSA-9021364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELF3 binds NOTCH3 gene promoter (Homo sapiens)
REACT:R-DME-430158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds VAV (Drosophila melanogaster)
REACT:R-DRE-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Danio rerio)
RHEA:38278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalyl-CoA <=> acetyl-CoA + pyruvate
REACT:R-MMU-72130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of an intermediate Spliceosomal C complex (Mus musculus)
EC:1.1.1.36	skos:prefLabel	"acetoacetyl-CoA reductase"
EC:1.1.1.36	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetoacetyl-CoA reductase"
RHEA:67650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + H(+) + triphosphate => dATP + H2O
RHEA:65955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a quinone + H(+) + NADH <=> 2 a 1,4-benzosemiquinone + NAD(+)
REACT:R-CEL-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Caenorhabditis elegans)
GO:0047960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine dehydrogenase activity
GO:0047960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine:NAD+ oxidoreductase (deaminating)
RHEA:72235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) = 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)
REACT:R-HSA-6814885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
REACT:R-HSA-9022870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOBP gene expression is inhibited by MECP2 (Homo sapiens)
REACT:R-SSC-5218812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates PAK2 (Sus scrofa)
REACT:R-DME-5635839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3:SUFU dissociates (Drosophila melanogaster)
REACT:R-SSC-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Sus scrofa)
REACT:R-DME-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Drosophila melanogaster)
REACT:R-SSC-9714480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the mitochondrial membrane (Sus scrofa)
RHEA:57870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate => (E)-4-coumaroyl-CoA + 2-oxoglutarate + O2
REACT:R-HSA-209921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoiodinated tyrosine can be deiodinated (Homo sapiens)
RHEA:11528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate
REACT:R-GGA-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Gallus gallus)
RHEA:49486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O
RHEA:52495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0016168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll binding
REACT:R-GGA-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Gallus gallus)
REACT:R-HSA-2029467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)
REACT:R-XTR-71260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Xenopus tropicalis)
REACT:R-RNO-2424480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
RHEA:37523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-CFA-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Canis familiaris)
RHEA:32646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + lupanine <=> 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-BTA-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Bos taurus)
REACT:R-DRE-9667619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B,2 bind atosiban (Danio rerio)
REACT:R-HSA-8877922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)
REACT:R-HSA-9627056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procaspase 9 forms dimer (Homo sapiens)
GO:0102571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
REACT:R-DRE-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Danio rerio)
REACT:R-MMU-5358343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT palmitoylates Hh N-terminal fragment (Mus musculus)
RHEA:72910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(out) + Na(+)(out) <=> D-mannose(in) + Na(+)(in)
RHEA:32993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-HSA-879910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 is phosphorylated, activated (Homo sapiens)
REACT:R-GGA-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Gallus gallus)
REACT:R-DME-5324632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Drosophila melanogaster)
RHEA:29347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + orotate(in) = 2 H(+)(out) + orotate(out)
REACT:R-CEL-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Caenorhabditis elegans)
RHEA:69717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-CoA + AMP + diphosphate => (indol-3-yl)acetate + ATP + CoA
REACT:R-SCE-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Saccharomyces cerevisiae)
RHEA:37112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine
RHEA:65488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP = 2',3',3'-c-tri-AMP + 3 diphosphate
REACT:R-CFA-198941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCAM1 binds Integrin alpha4beta1 (Canis familiaris)
REACT:R-RNO-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Rattus norvegicus)
REACT:R-DME-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Drosophila melanogaster)
REACT:R-SCE-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)
RHEA:27956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + presilphiperfolan-8beta-ol => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-DDI-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Dictyostelium discoideum)
REACT:R-HSA-381262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPARG:RXRA heterodimer (ARF6 complex) (Homo sapiens)
RHEA:43415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-galactosylceramide + H2O <=> an N-acyl-sphingoid base + D-galactose
RHEA:24420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]
RHEA:24420	skos:altLabel	"polypeptide deformylase"
RHEA:24420	skos:altLabel	"PDF"
RHEA:24420	skos:prefLabel	"peptide deformylase"
RHEA:24420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptide deformylase"
RHEA:41168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)
RHEA:65926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine => 2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine
REACT:R-HSA-9705467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 (Homo sapiens)
GO:0004342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosamine-6-phosphate deaminase activity
GO:0004342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglucosamine isomerase activity
GO:0004342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
GO:0004342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine phosphate deaminase activity
GO:0004342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglucosaminisomerase activity
GO:0004342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminodeoxyglucosephosphate isomerase activity
GO:0004342	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glucosaminephosphate isomerase
GO:0004342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcN6P deaminase activity
GO:0004342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine-6-phosphate isomerase activity
RHEA:49422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + valienone 7-phosphate => ATP + valienone
REACT:R-MMU-977375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR1 binds C3bBb/C4bC2a (Mus musculus)
RHEA:11242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + thiamine triphosphate => ATP + thiamine diphosphate
RHEA:18049	skos:altLabel	"N-acetylornithine-delta-transaminase"
RHEA:18049	skos:prefLabel	"acetylornithine transaminase"
RHEA:18049	skos:altLabel	"N-acetylornithine aminotransferase"
RHEA:18049	skos:altLabel	"acetylornithine 5-aminotransferase"
RHEA:18049	skos:altLabel	"acetylornithine aminotransferase"
RHEA:18049	skos:altLabel	"ACOAT"
RHEA:18049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde
RHEA:18049	skos:altLabel	"succinylornithine aminotransferase"
RHEA:18049	skos:altLabel	"N(2)-acetylornithine 5-transaminase"
RHEA:18049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylornithine transaminase"
RHEA:18049	skos:altLabel	"acetylornithine delta-transaminase"
REACT:R-MMU-8871265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD4 (Mus musculus)
REACT:R-CFA-4570485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO3 (Canis familiaris)
REACT:R-MMU-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Mus musculus)
REACT:R-CFA-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Canis familiaris)
REACT:R-GGA-873926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNGR (Gallus gallus)
REACT:R-DRE-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Danio rerio)
RHEA:23269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + H2O => glycine + urea
REACT:R-RNO-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Rattus norvegicus)
REACT:R-XTR-4641249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Xenopus tropicalis)
RHEA:64336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 malonyl-CoA + nicotinyl-CoA = 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-RNO-170076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Rattus norvegicus)
RHEA:16635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine + queuosine(34) in tRNA => guanosine(34) in tRNA + queuine
REACT:R-DME-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Drosophila melanogaster)
GO:0070551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoribonuclease activity, cleaving siRNA-paired mRNA
GO:0070551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	argonaute endoribonuclease activity
RHEA:63982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-thiouridine 5'-phosphate + ADP + H(+) => 4-thiouridine + ATP
REACT:R-XTR-1793209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses Chondroitin chains (Xenopus tropicalis)
REACT:R-DRE-5618093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP90 (Danio rerio)
RHEA:32396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4S)-dihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH
REACT:R-RNO-198983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NKG2D homodimer interacting with ligands (Rattus norvegicus)
REACT:R-SSC-2022378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Sus scrofa)
REACT:R-HSA-9684301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA1 is translated to pp1a (Homo sapiens)
REACT:R-CFA-192312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Canis familiaris)
REACT:R-SSC-2197691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIP binds WASP,N-WASP, activating them (Sus scrofa)
GO:0019176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroneopterin monophosphate dephosphorylase activity
GO:0019176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroneopterin monophosphate phosphatase activity
REACT:R-CFA-174097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdh1 (Canis familiaris)
REACT:R-BTA-2089971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of collagens (Bos taurus)
RHEA:70916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(in) + H(+)(in) => guanosine(out) + H(+)(out)
REACT:R-DME-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Drosophila melanogaster)
REACT:R-DME-168166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
REACT:R-XTR-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Xenopus tropicalis)
RHEA:51505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose => a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP
REACT:R-BTA-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)
REACT:R-SSC-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Sus scrofa)
RHEA:58524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + H2O + NADPH = (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)
REACT:R-SSC-5649705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Sus scrofa)
REACT:R-HSA-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)
RHEA:60651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphoethanolamine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine
RHEA:20462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-GGA-4655374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DNMT3B with SUMO1 (Gallus gallus)
RHEA:46733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,6)-dimethylheptanoyl-CoA => (2S,6)-dimethylheptanoyl-CoA
RHEA:65451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + ethanol <=> CoA + ethyl butanoate
REACT:R-MMU-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Mus musculus)
GO:0016087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysiostatic hormone activity
REACT:R-BTA-5609665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
REACT:R-BTA-3149518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRR reduces cob(II)alamin to meCbl (Bos taurus)
REACT:R-BTA-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Bos taurus)
REACT:R-CEL-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Caenorhabditis elegans)
REACT:R-DME-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Drosophila melanogaster)
RHEA:60822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADPH
RHEA:72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + 3 Li(+)(out) = Ca(2+)(out) + 3 Li(+)(in)
GO:0047739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin C deacetylase activity
GO:0047739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cephalosporin-C deacetylase activity
GO:0047739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin C acetyl-esterase activity
GO:0047739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin C acetylase activity
GO:0047739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin-C acetylhydrolase activity
GO:0047739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin C acetylesterase activity
GO:0047739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin acetylesterase activity
GO:0047739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin C acetyl-hydrolase activity
REACT:R-SSC-5671993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT-3 binds DLG4 (Sus scrofa)
RHEA:40204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:38988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonanoyl-CoA + O2 => (2E)-nonenoyl-CoA + H2O2
RHEA:34806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> bisdemethoxycurcumin + 2 CO2 + 3 CoA
REACT:R-XTR-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Xenopus tropicalis)
REACT:R-HSA-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)
RHEA:43961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-DRE-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Danio rerio)
RHEA:40225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoate + CoA + H(+) => 4,8-dimethylnonanoyl-CoA + H2O
REACT:R-XTR-5635102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 is internalized (Xenopus tropicalis)
REACT:R-CFA-8956099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Canis familiaris)
RHEA:37749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine
REACT:R-CFA-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Canis familiaris)
REACT:R-CEL-212706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipase C-gamma1 binds to the activated EGF receptor (Caenorhabditis elegans)
REACT:R-CFA-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Canis familiaris)
REACT:R-HSA-5654169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)
REACT:R-GGA-749452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gq complex dissociates (Gallus gallus)
GO:0140326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled intramembrane lipid transporter activity
GO:0140326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminophospholipid-transporting ATPase
GO:0140326	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phospholipid flippase activity
GO:0140326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospholipid-translocating ATPase activity
GO:0140326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospholipid translocating ATPase activity
GO:0140326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospholipid-transporting ATPase activity
GO:0140326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled phospholipid transporter activity
GO:0140326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-dependent phospholipid transporter activity
RHEA:70965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + H2O2 + NH4(+) => D-phenylalanine + H2O + O2
REACT:R-DRE-166726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MASPs (Danio rerio)
REACT:R-GGA-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Gallus gallus)
RHEA:32209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-2-oxohex-3-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate
REACT:R-HSA-110159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)
REACT:R-SPO-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)
GO:0102753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity
RHEA:62670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + herqueinone + NADP(+) => deoxyherqueinone + H(+) + NADPH + O2
REACT:R-BTA-9706304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRAP2 (Bos taurus)
GO:0008449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglucosamine 6-sulfatase activity
GO:0008449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity
GO:0008449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O,N-disulfate O-sulfohydrolase activity
GO:0008449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine-6-sulfatase activity
GO:0008449	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinsulfatase
GO:0008449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosamine 6-sulfate sulfatase activity
GO:0008449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity
GO:0008449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine-6-sulfatase activity
GO:0008449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine-6-sulphatase activity
REACT:R-RNO-8944246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXI (Rattus norvegicus)
REACT:R-MMU-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Mus musculus)
REACT:R-CFA-8937113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)
REACT:R-RNO-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Rattus norvegicus)
EC:4.2.3.66	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-selinene cyclase"
EC:4.2.3.66	skos:prefLabel	"beta-selinene cyclase"
GO:0033802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoliquiritigenin 2'-O-methyltransferase activity
GO:0033802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CHMT
GO:0033802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chalcone OMT
GO:0033802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity
REACT:R-GGA-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Gallus gallus)
REACT:R-BTA-1168459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lyn activates ERK (Bos taurus)
REACT:R-CFA-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Canis familiaris)
REACT:R-DRE-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Danio rerio)
REACT:R-SSC-5635868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-GLI is degraded by the proteasome (Sus scrofa)
GO:0102455	skos:prefLabel	"anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase"
GO:0102455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase"
GO:0102455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity
GO:0102455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP
RHEA:50008	skos:prefLabel	"6-methylpretetramide 4-monooxygenase"
RHEA:50008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylpretetramide + 2 H(+) + NADPH + O2 = 4-hydroxy-6-methylpretetramide + H2O + NADP(+)
RHEA:50008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-methylpretetramide 4-monooxygenase"
GO:0106347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity
GO:0106347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Bos taurus)
REACT:R-XTR-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Xenopus tropicalis)
RHEA:32797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-cysteine(in) + phosphate => ATP + H2O + L-cysteine(out)
RHEA:10039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-methoxy-benzenemethanol + O2 <=> H2O2 + vanillin
REACT:R-DRE-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Danio rerio)
RHEA:35236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + tetracycline(in) => H(+)(in) + tetracycline(out)
REACT:R-MMU-417829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds ADP (Mus musculus)
REACT:R-BTA-5682586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 and PIAS4 are recruited to DNA DSBs (Bos taurus)
RHEA:25554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + stemar-13-ene => 9alpha-copalyl diphosphate
REACT:R-BTA-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
RHEA:38990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonanoyl-CoA + O2 <=> (2E)-nonenoyl-CoA + H2O2
REACT:R-HSA-5604954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)
REACT:R-DRE-451056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Microtubule-independent trafficking of connexons to the plasma membrane (Danio rerio)
REACT:R-HSA-2514823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by ELANE (Homo sapiens)
RHEA:15437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + CoA + NADP(+) = a long-chain fatty acyl-CoA + H(+) + NADPH
RHEA:15437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-fatty-acyl-CoA reductase"
RHEA:15437	skos:prefLabel	"long-chain-fatty-acyl-CoA reductase"
RHEA:15437	skos:altLabel	"acyl-CoA reductase"
REACT:R-SSC-8853405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 binds AURKA at centrosomes (Sus scrofa)
REACT:R-DME-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Drosophila melanogaster)
REACT:R-DRE-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Danio rerio)
RHEA:72344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol
GO:0047037	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	salutaridinol:NADP+ 7-oxidoreductase activity
GO:0047037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salutaridine reductase (NADPH) activity
RHEA:47110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + taurocholate => cholate + taurine
RHEA:21497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O => diphosphate + prenol
REACT:R-GGA-982792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor binds JAK2 (Gallus gallus)
REACT:R-CEL-6810843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin binds periplakin (Caenorhabditis elegans)
REACT:R-DDI-193508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Dictyostelium discoideum)
REACT:R-MMU-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Mus musculus)
RHEA:54493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Homo sapiens)
RHEA:57091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)
RHEA:59863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP
REACT:R-MMU-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)
RHEA:31759	skos:prefLabel	"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase"
RHEA:31759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase"
RHEA:31759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-CEL-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Caenorhabditis elegans)
REACT:R-SCE-9635743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 binds p-T,Y-MAPK (Saccharomyces cerevisiae)
REACT:R-SCE-1483063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG and CDP-DAG are converted to CL by CRLS1 (Saccharomyces cerevisiae)
REACT:R-XTR-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Xenopus tropicalis)
RHEA:12627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + sinapoyl (S)-malate => (S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose
RHEA:37291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-leucine = L-alanine + L-leucine
GO:0102743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eriodictyol,NADPH:oxygen oxidoreductase activity
RHEA:64734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2
REACT:R-DME-983194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-1 is a heterotetramer (Drosophila melanogaster)
EC:1.6.3.1	skos:altLabel	"THOX2"
EC:1.6.3.1	skos:altLabel	"thyroid oxidase 2"
EC:1.6.3.1	skos:altLabel	"thyroid oxidase"
EC:1.6.3.1	skos:altLabel	"NAD(P)H oxidase"
EC:1.6.3.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(P)H oxidase (H2O2-forming)"
EC:1.6.3.1	skos:altLabel	"ThOX"
EC:1.6.3.1	skos:altLabel	"dual oxidase"
EC:1.6.3.1	skos:altLabel	"thyroid NADPH oxidase"
EC:1.6.3.1	skos:prefLabel	"NAD(P)H oxidase (H2O2-forming)"
REACT:R-RNO-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)
REACT:R-DRE-9624120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK2 (Danio rerio)
REACT:R-CEL-5610726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The IFT-A complex recruits TULP3 (Caenorhabditis elegans)
RHEA:44279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA
GO:0043996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H4-K8 specific)
GO:0043996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H4-K8 specific)
GO:0043996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H4-K8 specific)
GO:0043996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K8 acetyltransferase activity
RHEA:63466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP => (2E,6E,10E)-geranylgeraniol + UTP
REACT:R-HSA-3299657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective TCII does not bind Cbl in the circulation (Homo sapiens)
REACT:R-HSA-9021951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPRK1 gene expression is stimulated by MECP2 (Homo sapiens)
RHEA:47473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH => (3E)-tetradecenoyl-CoA + NADP(+)
REACT:R-DRE-8950453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Danio rerio)
REACT:R-RNO-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Rattus norvegicus)
REACT:R-SSC-8987039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL20RA (Sus scrofa)
REACT:R-CEL-877281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 binds p-STAT1 dimer (Caenorhabditis elegans)
REACT:R-XTR-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Xenopus tropicalis)
REACT:R-HSA-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Homo sapiens)
EC:4.2.2.11	skos:prefLabel	"guluronate-specific alginate lyase"
EC:4.2.2.11	skos:altLabel	"alginase II"
EC:4.2.2.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guluronate-specific alginate lyase"
EC:4.2.2.11	skos:altLabel	"poly(alpha-L-guluronate) lyase"
REACT:R-DRE-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)
RHEA:31170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanoyl-CoA + NAD(+) <=> 3-oxotetradecanoyl-CoA + H(+) + NADH
REACT:R-HSA-173597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose is oxidised to UDP-glucuronate (Homo sapiens)
REACT:R-SSC-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Sus scrofa)
REACT:R-CFA-1855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)
REACT:R-HSA-1433428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)
RHEA:61238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-methionine + O2
RHEA:52354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate
RHEA:17976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + IMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
RHEA:56856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxylate reductase"
RHEA:56856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldehyde dehydrogenase (FAD-independent)"
RHEA:56856	skos:altLabel	"aldehyde oxidoreductase"
RHEA:56856	skos:prefLabel	"carboxylate reductase"
RHEA:56856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + an aldehyde + H2O = a carboxylate + AH2 + H(+)
RHEA:56856	skos:prefLabel	"aldehyde dehydrogenase (FAD-independent)"
RHEA:56856	skos:altLabel	"AORDd"
RHEA:56856	skos:altLabel	"aldehyde oxidase"
RHEA:42254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoheptanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + pentanoyl-CoA
REACT:R-RNO-163820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Rattus norvegicus)
REACT:R-BTA-6797568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind CASK:Protein 4.1 (Bos taurus)
REACT:R-BTA-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Bos taurus)
REACT:R-SPO-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Schizosaccharomyces pombe)
GO:0050780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine receptor binding
REACT:R-MMU-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Mus musculus)
RHEA:31361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammoniodiacetate + FMN + glyoxylate + H2O => FMNH2 + nitrilotriacetate + O2
REACT:R-CEL-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Caenorhabditis elegans)
GO:0033219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea binding
RHEA:52251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 H2O + 4 Mn(3+) + O2 <=> 12 H(+) + 4 MnO2
EC:2.1.1.313	skos:prefLabel	"25S rRNA (uracil(2634)-N(3))-methyltransferase"
EC:2.1.1.313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"25S rRNA (uracil(2634)-N(3))-methyltransferase"
REACT:R-XTR-6788523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to Complex I subunits (Xenopus tropicalis)
REACT:R-RNO-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)
REACT:R-RNO-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Rattus norvegicus)
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopantetheinyltransferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	holo-ACP synthase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACPS activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl carrier protein synthetase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P-pant transferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4'-phosphopantetheinyl transferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPTase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	holo-[peptidyl-carrier protein] synthase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	holo-ACP synthetase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl carrier protein holoprotein (holo-ACP) synthetase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AcpS
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-phosphopantetheinyltransferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopantetheinyl transferase
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	holosynthase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	holo-acyl-carrier-protein synthase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate reductase phosphopantetheinyl transferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[acyl-carrier-protein] synthase activity
GO:0008897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl carrier protein synthase activity
REACT:R-BTA-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Bos taurus)
REACT:R-CFA-2395322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyridinoline cross-links (Canis familiaris)
RHEA:27272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + NADPH => CoA + hexadecanal + NADP(+)
REACT:R-CFA-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Canis familiaris)
REACT:R-HSA-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Homo sapiens)
RHEA:60118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + hydroxymethylphosphonate + succinate => 2-oxoglutarate + methylphosphonate + O2
RHEA:26188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP
RHEA:26188	skos:prefLabel	"D-inositol-3-phosphate glycosyltransferase"
RHEA:26188	skos:altLabel	"N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase"
RHEA:26188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-inositol-3-phosphate glycosyltransferase"
RHEA:26188	skos:altLabel	"mycothiol glycosyltransferase"
RHEA:72423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-AMP + CoA = (E)-4-coumaroyl-CoA + AMP + H(+)
RHEA:23616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-alpha-santonin + NADP(+) = alpha-santonin + H(+) + NADPH
REACT:R-BTA-9647619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD forms ring‐shaped oligomers  (Bos taurus)
RHEA:61115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate
REACT:R-SSC-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Sus scrofa)
REACT:R-DRE-114542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1,RAC2,RHOG activate PI3K (Danio rerio)
REACT:R-HSA-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)
REACT:R-HSA-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Homo sapiens)
RHEA:21861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate
REACT:R-SSC-8849646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK5(490-624) binds KLK5 (Sus scrofa)
RHEA:44635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dihydroxyphenyl)acetyl-CoA + O2 <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)
RHEA:23952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(2-phenylethyl)acetamide = 2-phenylethylamine + acetate
RHEA:49175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine
RHEA:59916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H2O + NADP(+) = (2E)-octenoate + 2 H(+) + NADPH
REACT:R-HSA-9010523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2 (Homo sapiens)
REACT:R-CFA-193497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Canis familiaris)
REACT:R-MMU-1605736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Mus musculus)
REACT:R-MMU-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Mus musculus)
REACT:R-HSA-9756150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV (Homo sapiens)
RHEA:57530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+) => a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O
REACT:R-RNO-2161660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGE2 by PTGES (Rattus norvegicus)
REACT:R-DRE-209738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 binds GC (Danio rerio)
RHEA:50984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E2(out) = prostaglandin E2(in)
RHEA:13901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(aminomethyl)urea = N-(hydroxymethyl)urea + NH4(+)
REACT:R-CFA-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Canis familiaris)
REACT:R-DRE-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Danio rerio)
RHEA:25006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9026890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2 phosphorylates SHC1 (Homo sapiens)
RHEA:39800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH
RHEA:49212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
RHEA:16815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + H(+) + L-alanine => H2O + L-kynurenine
GO:0050328	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-THB oxidase activity
GO:0050328	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	THB oxidase activity
GO:0050328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-canadine + H(+) + 2 O2 = berberine + 2 H2O2
GO:0050328	skos:prefLabel	"tetrahydroberberine oxidase"
GO:0050328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrahydroberberine oxidase"
GO:0050328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydroberberine oxidase activity
GO:0050328	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-tetrahydroberberine:oxygen oxidoreductase activity
GO:0050328	skos:altLabel	"THB oxidase"
REACT:R-HSA-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Homo sapiens)
RHEA:31628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethynolide + dTDP-alpha-D-desosamine => 10-deoxymethymycin + dTDP + H(+)
REACT:R-SSC-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Sus scrofa)
REACT:R-MMU-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Mus musculus)
RHEA:67777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O => a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate
RHEA:43673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-RNO-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Rattus norvegicus)
RHEA:12009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[G-protein-coupled receptor] + ATP => [G-protein-coupled receptor]-phosphate + ADP + H(+)
REACT:R-MMU-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Mus musculus)
REACT:R-XTR-1535903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Xenopus tropicalis)
RHEA:48738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:43121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + xanthine => CO2 + succinate + urate
RHEA:57478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydodecanoate + H2O => dodecanoate + H2O2
RHEA:61820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose = epiandrosterone 3-beta-D-glucoside + H(+) + UDP
EC:3.4.24.3	skos:altLabel	"Clostridium histolyticum collagenase"
EC:3.4.24.3	skos:altLabel	"collagenase A"
EC:3.4.24.3	skos:altLabel	"clostridiopeptidase A"
EC:3.4.24.3	skos:altLabel	"collagenase I"
EC:3.4.24.3	skos:prefLabel	"microbial collagenase"
EC:3.4.24.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"microbial collagenase"
REACT:R-RNO-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Rattus norvegicus)
GO:0070891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoteichoic acid binding
RHEA:31220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxykynurenamine + CO2 => 5-hydroxy-L-kynurenine + H(+)
RHEA:38648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)
REACT:R-DME-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Drosophila melanogaster)
REACT:R-XTR-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
RHEA:58521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:54786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide
REACT:R-BTA-9646348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Bos taurus)
REACT:R-RNO-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Rattus norvegicus)
REACT:R-BTA-1602473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP1 (Bos taurus)
REACT:R-RNO-5683967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Rattus norvegicus)
RHEA:38570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate
REACT:R-MMU-8853252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2:C3d,C3dg,iC3b binds CD19:CD81 (Mus musculus)
RHEA:12956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]
REACT:R-DDI-209815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is monoiodinated (Dictyostelium discoideum)
REACT:R-SPO-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Schizosaccharomyces pombe)
RHEA:28027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dUDP + H2O => [thioredoxin]-dithiol + UDP
RHEA:22141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 5'-phosphate + H2O => a nucleoside + phosphate
RHEA:32802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea(in) <=> urea(out)
RHEA:10994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H(+) + NADPH => glycolate + NADP(+)
REACT:R-HSA-75238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL binds TRAIL receptors (Homo sapiens)
RHEA:45807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydroxylamine + L-glutamate <=> ADP + L-glutamine hydroxamate + phosphate
RHEA:65535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-1-ol + hexanoyl-CoA <=> 2-methylbutyl hexanoate + CoA
REACT:R-XTR-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Xenopus tropicalis)
GO:0000511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2A-H2B histone carrier activity
GO:0000511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2A-H2B histone complex chaperone activity
RHEA:29199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + menaquinone-8 = menaquinol-8 + orotate
RHEA:62628	skos:altLabel	"alkyl hydroperoxide reductase"
RHEA:62628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)
RHEA:62628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADH-dependent peroxiredoxin"
RHEA:62628	skos:prefLabel	"NADH-dependent peroxiredoxin"
REACT:R-CFA-1234167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of HIF:CBP:p300 complex at promoters (Canis familiaris)
RHEA:11894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nororientaline + S-adenosyl-L-homocysteine => 6-O-methylnorlaudanosoline + S-adenosyl-L-methionine
RHEA:55480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-cassadiene hydroxylase"
RHEA:55480	skos:altLabel	"CYP71Z7"
RHEA:55480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:55480	skos:prefLabel	"ent-cassadiene hydroxylase"
RHEA:20037	skos:altLabel	"NADP-dependent D-sorbitol-6-phosphate dehydrogenase"
RHEA:20037	skos:prefLabel	"aldose-6-phosphate reductase (NADPH)"
RHEA:20037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldose-6-phosphate reductase (NADPH)"
RHEA:20037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol 6-phosphate + NADP(+) = aldehydo-D-glucose 6-phosphate + H(+) + NADPH
REACT:R-HSA-2399941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates BAD (Homo sapiens)
RHEA:62091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine 6-phosphate + NADP(+) <=> 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH
RHEA:13807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5alpha-steroid
REACT:R-DRE-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Danio rerio)
RHEA:60327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine
RHEA:47829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b + H2O => ganglioside GD1b + N-acetylneuraminate
RHEA:21793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propan-2-ol => acetone + H(+) + NADPH
GO:0019139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-dimethylallyladenine:(acceptor) oxidoreductase activity
GO:0019139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-N-dimethylallyladenine:acceptor oxidoreductase activity
GO:0019139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-dimethylallyladenine:acceptor oxidoreductase activity
GO:0019139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokinin dehydrogenase activity
GO:0019139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytokinin oxidase activity
RHEA:32931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cardiolipin synthase (CMP-forming)"
RHEA:32931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol = a cardiolipin + CMP + H(+)
RHEA:32931	skos:prefLabel	"cardiolipin synthase (CMP-forming)"
RHEA:29743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine(in) = 2-phenylethylamine(out)
REACT:R-MMU-5634750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Mus musculus)
REACT:R-HSA-2263444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SGSH does not hydrolyse Heparan sulfate chain(7) (Homo sapiens)
REACT:R-GGA-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Gallus gallus)
REACT:R-CEL-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Caenorhabditis elegans)
REACT:R-DRE-1592349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14 (MT1-MMP) binds TIMP2 (Danio rerio)
RHEA:38041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-HSA-9734475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds fibrates (Homo sapiens)
REACT:R-GGA-8938770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Gallus gallus)
REACT:R-MMU-196417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of desmosterol to cholesterol (Mus musculus)
RHEA:48893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-glucosamine
REACT:R-DRE-750988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (z) reassociates with G beta:gamma (Danio rerio)
REACT:R-DRE-8943007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Danio rerio)
RHEA:61571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine
GO:0003721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomerase, catalyst
GO:0003721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomerase RNA reverse transcriptase activity
GO:0102758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-long-chain enoyl-CoA reductase activity
REACT:R-BTA-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Bos taurus)
RHEA:48336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)
REACT:R-MMU-3296326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR1 binds LACT (Mus musculus)
REACT:R-MMU-2161791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Mus musculus)
RHEA:39214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexacosanoyl-CoA <=> (2E)-hexacosenoyl-CoA + H2O
GO:0008068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellularly glutamate-gated chloride channel activity
GO:0008068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular-glutamate-gated chloride channel activity
RHEA:21834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine
REACT:R-BTA-8938887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML binds RUNX1 (Bos taurus)
REACT:R-BTA-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Bos taurus)
RHEA:35747	skos:prefLabel	"7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]"
RHEA:35747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]"
RHEA:35747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = 7-epizingiberene + diphosphate
RHEA:64565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-epi-ilicicolin H => ilicicolin H
RHEA:25325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + phosphocholine + S-adenosyl-L-homocysteine
REACT:R-DME-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Drosophila melanogaster)
RHEA:21383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,11,15-tetramethylhexadecanoate + ATP + CoA <=> AMP + diphosphate + phytanoyl-CoA
RHEA:72276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate(in) + sulfate(out) => oxalate(out) + sulfate(in)
RHEA:36418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine
RHEA:11069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose
RHEA:55642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+) => C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate
REACT:R-SPO-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Schizosaccharomyces pombe)
REACT:R-RNO-2730864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TRAF6 to CBM complex by binding to MALT1 (Rattus norvegicus)
REACT:R-BTA-1592297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full activation of MMP1 (Bos taurus)
RHEA:22308	skos:altLabel	"xylitol oxidase"
RHEA:22308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alditol + O2 = an aldose + H2O2
RHEA:22308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + xylitol = D-xylose + H2O2
RHEA:22308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alditol oxidase"
RHEA:22308	skos:prefLabel	"alditol oxidase"
REACT:R-HSA-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)
REACT:R-DME-5654607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PPTN11 (Drosophila melanogaster)
RHEA:28930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate + O2 <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)
RHEA:69658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + quercetin 3-O-beta-D-glucoside <=> beta-D-glucose + quercetin
REACT:R-BTA-879942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor is activated (Bos taurus)
REACT:R-BTA-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Bos taurus)
RHEA:30716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol => (S)-linalool
REACT:R-DRE-996727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST recruits the BHC complex (Danio rerio)
RHEA:27684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dTTP => ATP + dTDP
RHEA:39934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)
REACT:R-DME-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Drosophila melanogaster)
RHEA:16406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) => benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH
GO:0070300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidic acid binding
GO:0070300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidate binding
REACT:R-GGA-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Gallus gallus)
REACT:R-BTA-193719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Bos taurus)
GO:0003858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-beta-hydroxybutyrate dehydrogenase activity
GO:0003858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutyrate dehydrogenase activity
REACT:R-DRE-8863914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of SEC22B, TAP and PLC from ER to ERGIC (Danio rerio)
RHEA:17038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-ethanol + NADP(+) => H(+) + indole-3-acetaldehyde + NADPH
RHEA:11850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + glycine betaine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine
RHEA:69325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate => 4-methylsulfanylbutyl isothionate + H(+) + sulfate
RHEA:21781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cyclohexanone => AH2 + cyclohex-2-enone
RHEA:69395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:19597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginine deiminase"
RHEA:19597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine = L-citrulline + NH4(+)
RHEA:19597	skos:altLabel	"arginine dihydrolase"
RHEA:19597	skos:prefLabel	"arginine deiminase"
REACT:R-HSA-110231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by MBD4 glycosylase (Homo sapiens)
GO:0047302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity
GO:0047302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity
GO:0047302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity
GO:0047302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity
GO:0047302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity
REACT:R-RNO-9709406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to Cytochrome c oxidase (Rattus norvegicus)
RHEA:49344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:16048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP
GO:1990239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid hormone binding
REACT:R-MMU-8851044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN1A1 binds xanthine oxidoreductase (XDH) (Mus musculus)
RHEA:30078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H2O <=> cytosine + D-ribose 5-phosphate
RHEA:55837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + UDP-alpha-D-glucuronate => calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP
REACT:R-MMU-9023626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)
REACT:R-HSA-9612073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression (Homo sapiens)
GO:0050698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteoglycan sulfotransferase activity
GO:0050698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteoglycan sulphotransferase activity
GO:0050698	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proteoglycan sulfate transfer
REACT:R-HSA-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Homo sapiens)
RHEA:68702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate
RHEA:51014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacylglycerol + H(+) + phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + H2O
GO:0008740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rhamnose isomerase activity
GO:0008740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnose aldose-ketose-isomerase activity
GO:0008740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnose ketol-isomerase activity
GO:0008740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnose isomerase activity
RHEA:52148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose = an aliphatic (Z)-desulfo-glucosinolate + UDP
REACT:R-DME-9024326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Drosophila melanogaster)
RHEA:48592	skos:altLabel	"nitrate inducible formate dehydrogenase"
RHEA:48592	skos:prefLabel	"formate dehydrogenase-N"
RHEA:48592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + formate + H(+) = a quinol + CO2
RHEA:48592	skos:altLabel	"formate dehydrogenase N"
RHEA:48592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate dehydrogenase-N"
RHEA:52474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate
REACT:R-HSA-1248694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)
REACT:R-RNO-1170539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor is internalized (Rattus norvegicus)
REACT:R-SSC-418918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The UDP/CysLT (P2Y17) receptor can bind UTP (Sus scrofa)
REACT:R-MMU-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Mus musculus)
RHEA:33652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + ATP + CoA => (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
RHEA:60240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate
REACT:R-CEL-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Caenorhabditis elegans)
RHEA:13169	skos:prefLabel	"maleate isomerase"
RHEA:13169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maleate isomerase"
RHEA:13169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleate = fumarate
REACT:R-XTR-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Xenopus tropicalis)
RHEA:13178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-5-dehydro-2-deoxy-D-gluconate => 3-oxopropanoate + dihydroxyacetone phosphate
RHEA:60804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A19 + O2 = CO2 + gibberellin A17 + H(+) + succinate
GO:0050599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)
GO:0050599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetoxycephalosporin-C synthase activity
GO:0050599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	expandase activity
GO:0050599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penicillin N expandase activity
GO:0050599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAOCS activity
GO:0050599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetoxycephalosporin C synthetase activity
GO:0050599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAOC synthase activity
REACT:R-BTA-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Bos taurus)
REACT:R-HSA-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Homo sapiens)
GO:0098619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenocysteine-tRNA ligase activity
GO:0098619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer (Homo sapiens)
REACT:R-CFA-389532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A binds CTLA4 dimer (Canis familiaris)
REACT:R-RNO-2559639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV sulfilimine cross-linking by peroxidasin (Rattus norvegicus)
RHEA:36876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA
REACT:R-MMU-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Mus musculus)
RHEA:17469	skos:altLabel	"retinyl ester synthase"
RHEA:17469	skos:altLabel	"lecithin--retinol acyltransferase"
RHEA:17469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylcholine--retinol O-acyltransferase"
RHEA:17469	skos:altLabel	"lecithin-retinol acyltransferase"
RHEA:17469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]
RHEA:17469	skos:altLabel	"lecithin retinol acyl transferase"
RHEA:17469	skos:prefLabel	"phosphatidylcholine--retinol O-acyltransferase"
REACT:R-RNO-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Rattus norvegicus)
GO:0016223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine-pyruvate transaminase activity
GO:0016223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-alanine--pyruvate aminotransferase activity
GO:0016223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	omega-amino acid--pyruvate aminotransferase activity
GO:0016223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine:3-oxopropanoate aminotransferase activity
GO:0016223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-alanine-alpha-alanine transaminase activity
GO:0016223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine-pyruvate aminotransferase activity
GO:0102322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-propylphenol monooxygenase activity
RHEA:22562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxyformononetin + 2 H(+) + NADPH => (3R)-vestitone + NADP(+)
REACT:R-HSA-165182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of complexed TSC2 by PKB (Homo sapiens)
REACT:R-CFA-5672957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates KSR1 (Canis familiaris)
REACT:R-DRE-9733973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts bind FABP6 (Danio rerio)
RHEA:62608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + H(+) + hydrogen sulfide + ubiquinone-10 = S-sulfanylglutathione + ubiquinol-10
REACT:R-HSA-163416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP (Homo sapiens)
REACT:R-DRE-9759206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Danio rerio)
REACT:R-BTA-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Bos taurus)
RHEA:13346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]
RHEA:27358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide + S-adenosyl-L-methionine => iodomethane + S-adenosyl-L-homocysteine
RHEA:59703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellopentaono-1,5-lactone + H2O <=> D-cellopentaonate + H(+)
REACT:R-MMU-72647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cap-bound mRNA is activated by helicases  (Mus musculus)
REACT:R-GGA-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Gallus gallus)
GO:0018421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity
GO:0000102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine porter activity
GO:0000102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine secondary active transmembrane transporter activity
RHEA:31025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammara-20,24-diene => squalene
REACT:R-DDI-2161917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15S-HpETE to LXA4/B4 (Dictyostelium discoideum)
REACT:R-BTA-5687091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 binds MAPKAPK5 (Bos taurus)
RHEA:50151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid ethyl ester + H2O <=> a fatty acid + ethanol + H(+)
RHEA:38760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:20043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + malonate + NADPH => 3-oxopropanoate + H2O + NADP(+)
REACT:R-HSA-9640368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Tegument to HCMV Nucleocapsid C (Homo sapiens)
GO:0043741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-aminoadipate N-acetyltransferase activity
GO:0043741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate acetyltransferase activity
REACT:R-DRE-5625717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PKN1 binds androgen receptor (AR) (Danio rerio)
RHEA:68925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + hexanoate + NADPH => AMP + diphosphate + hexanal + NADP(+)
RHEA:13490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-canadine + H(+) + 2 O2 => berberine + 2 H2O2
RHEA:39163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-CoA + NADP(+)
REACT:R-GGA-389463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteinase-activated receptors can bind thrombin (Gallus gallus)
REACT:R-XTR-5678313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Xenopus tropicalis)
RHEA:45975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)
REACT:R-CEL-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Caenorhabditis elegans)
RHEA:70184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 alpha-isomaltosyl-(1->4)-D-maltotriose => alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose
REACT:R-HSA-4608862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCRIB is required for asymmetric membrane localization of VANGL2 (Homo sapiens)
REACT:R-GGA-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Gallus gallus)
REACT:R-DRE-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Danio rerio)
REACT:R-HSA-9645672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p14ARF translocates to the nucleus (Homo sapiens)
REACT:R-RNO-3134954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX9 binds DNA (Rattus norvegicus)
REACT:R-MMU-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Mus musculus)
REACT:R-SSC-446372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  PARVA with TESK1 (Sus scrofa)
RHEA:42751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(967) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:26434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan synthase (indole-salvaging)"
RHEA:26434	skos:prefLabel	"tryptophan synthase (indole-salvaging)"
RHEA:26434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole + L-serine = H2O + L-tryptophan
RHEA:26434	skos:altLabel	"tryptophan synthase beta2"
REACT:R-DME-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Drosophila melanogaster)
REACT:R-CFA-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Canis familiaris)
REACT:R-HSA-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Homo sapiens)
REACT:R-DDI-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Dictyostelium discoideum)
REACT:R-PFA-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Plasmodium falciparum)
REACT:R-CFA-2404199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:IGF1R autophosphorylates (Canis familiaris)
RHEA:72290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dimethylsuccinate(out) + 3 Na(+)(out) <=> 2,2-dimethylsuccinate(in) + 3 Na(+)(in)
REACT:R-BTA-109813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1 binds SOS1 (Bos taurus)
RHEA:31508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate
RHEA:65624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine
REACT:R-DRE-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Danio rerio)
REACT:R-CFA-5654679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR3 (Canis familiaris)
RHEA:70097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peniphenone D => (R)-5-methyl-tetronate + o-quinone methide
RHEA:67543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine
REACT:R-CEL-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
GO:0034581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyloct-2-enoyl-CoA hydratase activity
REACT:R-CFA-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Canis familiaris)
RHEA:63575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin-(1-8) <=> L-arginine + neurotensin-(1-7)
RHEA:70104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + o-quinone methide + penilactone D => penilactone B
REACT:R-XTR-2176475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Xenopus tropicalis)
RHEA:62568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-benzyl-L-cysteinylglycine = glycine + S-benzyl-L-cysteine
REACT:R-HSA-176631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Homo sapiens)
REACT:R-BTA-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Bos taurus)
RHEA:71832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + creatine(out) + 2 Na(+)(out) => chloride(in) + creatine(in) + 2 Na(+)(in)
EC:1.3.1.105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methylene-furan-3-one reductase"
EC:1.3.1.105	skos:altLabel	"enone oxidoreductase"
EC:1.3.1.105	skos:prefLabel	"2-methylene-furan-3-one reductase"
RHEA:14774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 NADPH + palmatine + S-adenosyl-L-methionine => corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine
RHEA:58925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol => (-)-maackiain + H2O
RHEA:32670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methanethiol <=> H(+) + hydrogen sulfide + methyl-coenzyme M
RHEA:20316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP <=> 1D-myo-inositol hexakisphosphate + ADP + H(+)
REACT:R-HSA-6798474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Zn2+ (Homo sapiens)
RHEA:46337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-4,17-dien-22-oyl-CoA + H2O => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA
RHEA:11597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + orotidine 5'-phosphate => CO2 + UMP
REACT:R-HSA-9665404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 (Homo sapiens)
GO:0043565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence-specific DNA binding
GO:0043565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence specific DNA binding
REACT:R-DME-433099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS2 co-transports sulphate and two sodium ions (Drosophila melanogaster)
RHEA:44392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:52952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-GGA-9678737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR1:TYK2 binds TYK2 inhibitors (Gallus gallus)
RHEA:53946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH => 2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+)
RHEA:52311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH
REACT:R-XTR-8869568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM1 binds TFAP2A homodimer (Xenopus tropicalis)
RHEA:42682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 hercynylselenocysteine => 2 hercynine + 2 L-selenocysteine + O2
RHEA:68899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + H(+) + NADPH <=> 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)
RHEA:68360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylono-1,4-lactone + O2 = dehydro-L-arabinono-1,4-lactone + H(+) + H2O2
REACT:R-CFA-1549564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPTN11 dephosphorylates SPRY2 (Canis familiaris)
REACT:R-CFA-6786048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Canis familiaris)
RHEA:15012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + H(+) + NADPH
RHEA:13914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine => D-threonine
REACT:R-DRE-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
RHEA:41013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n)
RHEA:19608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a chlorophyll + H2O <=> a chlorophyllide + H(+) + phytol
REACT:R-CFA-448703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family precursors are cleaved by caspase-1 (Canis familiaris)
EC:3.4.23.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plasmepsin II"
EC:3.4.23.39	skos:altLabel	"aspartic hemoglobinase II"
EC:3.4.23.39	skos:altLabel	"PfAPD"
EC:3.4.23.39	skos:prefLabel	"plasmepsin II"
RHEA:38054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA <=> 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-BTA-77254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Bos taurus)
RHEA:19701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-glycoside + UDP-alpha-D-xylose = a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP
RHEA:19701	skos:prefLabel	"flavonol-3-O-glycoside xylosyltransferase"
RHEA:19701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonol-3-O-glycoside xylosyltransferase"
REACT:R-SSC-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Sus scrofa)
REACT:R-HSA-1855187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 transports from the nucleus to the ER lumen (Homo sapiens)
REACT:R-DME-209235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BSK kinase transports from the cytosol to the nucleus (Drosophila melanogaster)
REACT:R-HSA-9629004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MCP:pPR-AP:pAP Complex into the Nucleous (Homo sapiens)
RHEA:65906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine => 3-hydroxy-L-kynurenine + glyoxylate
REACT:R-GGA-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Gallus gallus)
RHEA:65525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6814165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates CSA to HTAU (Homo sapiens)
GO:0003866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-enolpyruvylshikimate-3-phosphate synthase activity
GO:0003866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity
GO:0003866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO:0003866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-enol-pyruvoylshikimate-5-phosphate synthase activity
GO:0003866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	EPSP synthase activity
RHEA:14186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + H(+) => 2-phenylacetaldehyde + CO2
REACT:R-DRE-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Danio rerio)
REACT:R-RNO-373748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD72 (Rattus norvegicus)
REACT:R-BTA-350578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO1 interaction with ODC (Bos taurus)
REACT:R-BTA-8937113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Bos taurus)
RHEA:55740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oleuropein = D-glucose + oleuropein aglycone
RHEA:55740	skos:prefLabel	"oleuropein beta-glucosidase"
RHEA:55740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oleuropein beta-glucosidase"
REACT:R-BTA-3788748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL6 promoter (Bos taurus)
REACT:R-BTA-9018594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds LBR (Bos taurus)
RHEA:24019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-epivellosimine + acetyl-CoA <=> CoA + vinorine
RHEA:61126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin => kaempferol + O2 + reduced [NADPH--hemoprotein reductase]
EC:3.4.21.95	skos:altLabel	"factor V-activating proteinase"
EC:3.4.21.95	skos:prefLabel	"snake venom factor V activator"
EC:3.4.21.95	skos:altLabel	"RVV-V component"
EC:3.4.21.95	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"snake venom factor V activator"
REACT:R-MMU-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Mus musculus)
REACT:R-RNO-2466085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from R* to release atRAL (Rattus norvegicus)
REACT:R-SCE-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Saccharomyces cerevisiae)
RHEA:39203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetracosenoyl-CoA + H(+) + NADPH = NADP(+) + tetracosanoyl-CoA
REACT:R-CFA-5653756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM25 binds monoUb:164-PCNA (Canis familiaris)
RHEA:67955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:47533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
REACT:R-MMU-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Mus musculus)
REACT:R-CFA-435244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM1 is phosphorylated (Canis familiaris)
REACT:R-RNO-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
RHEA:51757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + diphosphate
REACT:R-HSA-165162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TSC2 by PKB (Homo sapiens)
RHEA:50115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + taurine <=> CoA + H(+) + N-octadecanoyl-taurine
REACT:R-HSA-194808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botF LC cleaves target cell VAMP1 (Homo sapiens)
REACT:R-MMU-5228508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates PML with SUMO1 (Mus musculus)
REACT:R-RNO-8944257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIV (Rattus norvegicus)
RHEA:22662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + AMP + diphosphate => a fatty acid + ATP + holo-[ACP]
RHEA:14792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP
REACT:R-HSA-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
REACT:R-MMU-6807224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-BGLAP to BGLAP (Mus musculus)
RHEA:41217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O
RHEA:46081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetracosenoyl-CoA + H(+) + NADH => NAD(+) + tetracosanoyl-CoA
REACT:R-SSC-202541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)
RHEA:54472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate
GO:0047174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caffeoyl-CoA putrescine N-caffeoyl transferase activity
GO:0047174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PHT
GO:0047174	skos:prefLabel	"putrescine N-hydroxycinnamoyltransferase"
GO:0047174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity
GO:0047174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine hydroxycinnamoyltransferase activity
GO:0047174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine N-hydroxycinnamoyltransferase activity
GO:0047174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine hydroxycinnamoyl transferase activity
GO:0047174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity
GO:0047174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + putrescine = CoA + H(+) + N-caffeoylputrescine
GO:0047174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"putrescine N-hydroxycinnamoyltransferase"
REACT:R-RNO-1295613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds GRB2 (Rattus norvegicus)
RHEA:49818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide => 3 Fe(III)-[cytochrome c] + H2O + hydrazine
RHEA:26399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => all-trans-zeaxanthin + 2 O2
RHEA:35724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:33436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fecosterol => episterol
RHEA:42289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-[ACP] + H(+) + L-alanine => (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]
REACT:R-DDI-110354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of OGG1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)
RHEA:27962	skos:altLabel	"PQQ-dependent inositol dehydrogenase"
RHEA:27962	skos:prefLabel	"quinoprotein inositol dehydrogenase"
RHEA:27962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + pyrroloquinoline quinone = H(+) + pyrroloquinoline quinol + scyllo-inosose
RHEA:27962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinoprotein inositol dehydrogenase"
RHEA:27962	skos:altLabel	"membrane-bound quinoprotein inositol dehydrogenase"
RHEA:27962	skos:altLabel	"QIDH"
REACT:R-DRE-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Danio rerio)
RHEA:28600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-lysine => H2O + N-acetyl-L-lysine
REACT:R-GGA-205008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF binds to p62 (Sequestosome) (Gallus gallus)
REACT:R-SSC-1169192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B dephosphorylates GHR (Sus scrofa)
REACT:R-DME-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Drosophila melanogaster)
RHEA:20583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hydroxylamine + NADH => H2O + NAD(+) + NH4(+)
REACT:R-CFA-3788745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL8 promoter (Canis familiaris)
RHEA:25864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine
REACT:R-GGA-379382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates DA to DOPAC (Gallus gallus)
RHEA:43404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP
REACT:R-BTA-9660192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR agonists bind VDR (Bos taurus)
RHEA:51029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloroindole-3-pyruvate imine dimer + 2 H2O
GO:0046990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-hydroxy-2-aminofluorene-O-acetyltransferase activity
GO:0046990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity
GO:0046990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylhydroxamate N,O-acetyltransferase activity
GO:0046990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxyarylamine O-acetyltransferase activity
REACT:R-GGA-5684008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBN binds KPNA2 (Gallus gallus)
RHEA:62084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)
REACT:R-SSC-9649108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer binds 5HT (Sus scrofa)
RHEA:24247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pseudotropine <=> H(+) + NADPH + tropinone
GO:0004956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D receptor activity
GO:0004956	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGD receptor activity
GO:0004956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD(2) receptor activity
REACT:R-HSA-5660752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X deubiquitinates Ub-SNCA (Homo sapiens)
REACT:R-CEL-5205652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 recruits Parkin to the outer mitochondrial membrane. (Caenorhabditis elegans)
REACT:R-DME-6809325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)
RHEA:45467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Drosophila melanogaster)
RHEA:45413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin D2-1-glycerol ester => glycerol + H(+) + prostaglandin D2
RHEA:27832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-phellandrene + diphosphate => neryl diphosphate
REACT:R-MMU-9023840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HATs and coactivators are recruited to the CTSD gene (Mus musculus)
REACT:R-MMU-9692376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL2 binds BCL2 antagonists (Mus musculus)
RHEA:36682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-alpha-D-allose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH
REACT:R-GGA-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Gallus gallus)
REACT:R-HSA-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Homo sapiens)
REACT:R-RNO-109514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Rattus norvegicus)
REACT:R-HSA-9703442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FLT3 fusions bind GRB2 (Homo sapiens)
REACT:R-MMU-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Mus musculus)
REACT:R-SSC-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Sus scrofa)
REACT:R-GGA-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)
GO:0008742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ribulose 5-phosphate 4-epimerase activity
GO:0008742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ru5P activity
GO:0008742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribulose phosphate 4-epimerase activity
GO:0008742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribulose isomerase activity
GO:0008742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-Ru5P
GO:0008742	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-ribulose-5-phosphate 4-epimerase
GO:0008742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AraD
GO:0008742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose-phosphate 4-epimerase activity
REACT:R-GGA-2424481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)
REACT:R-DME-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Drosophila melanogaster)
REACT:R-RNO-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Rattus norvegicus)
RHEA:30288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 2 a plastoquinone => 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol
GO:0106417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopaminechrome = 5,6-dihydroxyindole
GO:0106417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopaminechrome tautomerase activity
RHEA:68908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + picolinate = AMP + diphosphate + NADP(+) + picolinal
RHEA:43771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkylamine + L-glutaminyl-[protein] <=> N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)
REACT:R-DME-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Drosophila melanogaster)
REACT:R-MMU-8849891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-3 bind to PSD-95 family members (Mus musculus)
RHEA:12489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate => 2-dehydro-3-deoxy-D-gluconate + NH4(+)
RHEA:12075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (S)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)
REACT:R-HSA-5685649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPAs translocate from ER membrane to extracellular region (Homo sapiens)
GO:0003836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity
GO:0003836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity
GO:0003836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
REACT:R-DRE-158145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Danio rerio)
RHEA:62175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylethanolamine phosphate + H2O <=> an N-acylethanolamine + phosphate
REACT:R-HSA-9729260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates nucleoprotein (Homo sapiens)
RHEA:29153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out)
RHEA:16925	skos:altLabel	"trans-caffeoyl-CoA 3-O-methyltransferase"
RHEA:16925	skos:prefLabel	"caffeoyl-CoA O-methyltransferase"
RHEA:16925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + S-adenosyl-L-methionine = (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine
RHEA:16925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caffeoyl-CoA O-methyltransferase"
REACT:R-MMU-8854899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Mus musculus)
REACT:R-SSC-5635864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH ubiquitinates GLI1 (Sus scrofa)
REACT:R-BTA-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)
REACT:R-MMU-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Mus musculus)
RHEA:69989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+)
RHEA:68195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + phytol <=> CoA + decanoate phytyl ester
REACT:R-DRE-9653503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B is phosphorylated on serine 181 (Danio rerio)
REACT:R-MMU-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Mus musculus)
REACT:R-CFA-391940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 and EP4 receptors can bind PGE2 (Canis familiaris)
REACT:R-GGA-9021520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds WWP2 (Gallus gallus)
REACT:R-RNO-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Rattus norvegicus)
REACT:R-SSC-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Sus scrofa)
REACT:R-HSA-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Homo sapiens)
REACT:R-BTA-873921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of STAT1 to p-IFNGR1 (Bos taurus)
REACT:R-CFA-388900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurotensin receptors can bind neurotensins (Canis familiaris)
REACT:R-HSA-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Homo sapiens)
RHEA:72382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + iodide(in) <=> chloride(in) + iodide(out)
RHEA:71986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene B
GO:0055131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3HC4-type RING finger domain binding
RHEA:61432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-epi-iridoid synthase"
RHEA:61432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH
RHEA:61432	skos:prefLabel	"7-epi-iridoid synthase"
REACT:R-GGA-451482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated MEK2 binds ERK2 (Gallus gallus)
REACT:R-RNO-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Rattus norvegicus)
REACT:R-XTR-8963915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D binds VDR (Xenopus tropicalis)
GO:0019874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-aminohexanoate-cyclic-dimer hydrolase activity
GO:0019874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity
REACT:R-HSA-9761834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds the TKT gene (Homo sapiens)
RHEA:30000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + spermidine(out) => ADP + H(+) + phosphate + spermidine(in)
RHEA:28748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+)(in) => NH4(+)(out)
GO:0018830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-hexachlorocyclohexane dehydrochlorinase activity
REACT:R-DRE-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Danio rerio)
RHEA:50050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + cholate(out) + H(+) + phosphate => ATP + cholate(in) + H2O
RHEA:57974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-388529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholecystokinin receptors bind cholecystokinin (Homo sapiens)
REACT:R-SSC-4827383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Sus scrofa)
RHEA:53065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxyestrone + UDP-alpha-D-glucuronate => 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-RNO-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
REACT:R-CEL-193766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
REACT:R-XTR-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Xenopus tropicalis)
RHEA:49333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:24476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + maleimide = H(+) + maleamate
RHEA:24476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maleimide hydrolase"
RHEA:24476	skos:altLabel	"imidase"
RHEA:24476	skos:prefLabel	"maleimide hydrolase"
RHEA:24476	skos:altLabel	"cyclic imide hydrolase"
RHEA:49858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:16693	skos:altLabel	"alpha-pinene oxide lyase"
RHEA:16693	skos:prefLabel	"alpha-pinene-oxide decyclase"
RHEA:16693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal
RHEA:16693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-pinene-oxide decyclase"
RHEA:36866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O
REACT:R-HSA-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Homo sapiens)
REACT:R-XTR-2534346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAM1 Binds Hyaluronic Acid (Xenopus tropicalis)
REACT:R-CEL-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Caenorhabditis elegans)
REACT:R-DME-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
REACT:R-SSC-2046089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Sus scrofa)
RHEA:55556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O
REACT:R-BTA-4608852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 ubiquitinates PRICKLE1 (Bos taurus)
REACT:R-SSC-190268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to Klotho-bound FGF23 (Sus scrofa)
REACT:R-DME-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Drosophila melanogaster)
REACT:R-CEL-8877153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 binds PC (Caenorhabditis elegans)
REACT:R-CFA-5624494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 binds p21 RAS:GTP (Canis familiaris)
REACT:R-DRE-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Danio rerio)
RHEA:39062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde => 7,8-dihydroneopterin
REACT:R-XTR-5625849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM1A binds KLK2 and KLK3 promoters (Xenopus tropicalis)
RHEA:10307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]
RHEA:49075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene + 2 FMNH2 + 2 O2 <=> dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O
REACT:R-DRE-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Danio rerio)
RHEA:14975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate => L-aspartate
REACT:R-DRE-176702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Processive Complex and Completed Telomere End (Danio rerio)
GO:0102790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 5,3-O-glycosyltransferase activity
REACT:R-HSA-173111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of viral capsid (Homo sapiens)
REACT:R-MMU-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Mus musculus)
RHEA:19672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O <=> GDP + H(+) + phosphate
RHEA:17284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-4-acetamido-2-aminobutanoate <=> H2O + L-ectoine
RHEA:71373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone 17-sulfate(in) + 2 Na(+)(in) => epitestosterone 17-sulfate(out) + 2 Na(+)(out)
RHEA:13318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate + H(+) => (R)-glycerate + CO2
RHEA:43556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
REACT:R-BTA-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Bos taurus)
RHEA:22446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + H(+) + NADPH => (E)-coniferol + NADP(+)
REACT:R-HSA-428231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Homo sapiens)
RHEA:65483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + hexan-1-ol <=> CoA + hexyl 2-methylbutanoate
GO:1990459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferrin receptor binding
REACT:R-SSC-8985988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Sus scrofa)
RHEA:30674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiose <=> 2 N-acetyl-D-glucosamine
GO:0140629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conductance calcium-activated potassium channel inhibitor activity
REACT:R-GGA-353039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphosphoglycerate + ADP <=> 3-phosphoglycerate + ATP (Gallus gallus)
REACT:R-MMU-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Mus musculus)
REACT:R-XTR-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Xenopus tropicalis)
REACT:R-XTR-139919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BIM to mitochondria (Xenopus tropicalis)
REACT:R-DME-450474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates BRF1 (Drosophila melanogaster)
RHEA:48057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => beta-D-glucosylceramide + D-galactose
REACT:R-XTR-432195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Xenopus tropicalis)
REACT:R-RNO-2161907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Rattus norvegicus)
GO:0045481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-exo-hydroxy-1,8-cineole + NAD(+) = 6-oxocineole + H(+) + NADH
GO:0045481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-endo-hydroxycineole dehydrogenase activity
GO:0045481	skos:prefLabel	"6-endo-hydroxycineole dehydrogenase"
GO:0045481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-endo-hydroxycineole dehydrogenase"
GO:0045481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity
RHEA:66028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[methyl coenzyme M reductase]-L-arginine C-5-methyltransferase"
RHEA:66028	skos:prefLabel	"[methyl coenzyme M reductase]-L-arginine C-5-methyltransferase"
RHEA:66028	skos:altLabel	"methanogenesis marker protein 10"
RHEA:66028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine = (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
REACT:R-CFA-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Canis familiaris)
REACT:R-BTA-378956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone is a heterodimer (Bos taurus)
REACT:R-CEL-5675194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPK phosphorylates RAF1 (Caenorhabditis elegans)
REACT:R-PFA-4724284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Plasmodium falciparum)
REACT:R-XTR-6785181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 bind LIPC dimer (Xenopus tropicalis)
RHEA:71191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)
RHEA:29783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-cysteine(in) = ADP + H(+) + L-cysteine(out) + phosphate
RHEA:22147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate + H2O <=> D-threo-isocitrate
REACT:R-DRE-216064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha8beta1 with Tenascin-C (Danio rerio)
REACT:R-RNO-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Rattus norvegicus)
RHEA:72746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene C4(out) <=> leukotriene C4(in)
REACT:R-HSA-5618105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)
REACT:R-DRE-2424243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Danio rerio)
GO:0140836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain S5 kinase activity
REACT:R-CEL-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Caenorhabditis elegans)
RHEA:44494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine
REACT:R-HSA-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Homo sapiens)
REACT:R-DME-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Drosophila melanogaster)
REACT:R-XTR-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Xenopus tropicalis)
RHEA:68116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol = a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol
RHEA:60376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) = D-glucose(in)
RHEA:49492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O
REACT:R-HSA-8853325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasma membrane FGFR1 fusions autophosphorylate (Homo sapiens)
GO:0047225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	core 6beta-GalNAc-transferase B
GO:0047225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0047225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity
GO:0047225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	core 4 beta6-GalNAc-transferase activity
GO:0047225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	core 6-beta-GalNAc-transferase B activity
GO:0047225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity
GO:0047225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B
REACT:R-CFA-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Canis familiaris)
REACT:R-SSC-5686074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Sus scrofa)
REACT:R-MMU-1482887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Mus musculus)
RHEA:63148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-taurine = (9Z)-octadecenoate + taurine
REACT:R-SSC-5622134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRABP1 binds atRA (Sus scrofa)
REACT:R-MMU-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)
RHEA:17484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(I)alamin + H(+) + NAD(+) <=> 2 cob(II)alamin + NADH
RHEA:14752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate + O2 <=> (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)
REACT:R-DRE-9750555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Danio rerio)
REACT:R-DRE-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Danio rerio)
RHEA:51392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + serotonin = CoA + H(+) + N-(9Z-octadecenoyl)-serotonin
REACT:R-HSA-1989759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of G0S2 (Homo sapiens)
REACT:R-RNO-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Rattus norvegicus)
RHEA:36139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate
REACT:R-BTA-965067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)
RHEA:53042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate
REACT:R-CEL-265426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Tenascin (Caenorhabditis elegans)
RHEA:41649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aniline + ATP + L-glutamate => ADP + N(5)-phenyl-L-glutamine + phosphate
RHEA:72074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + NAD(+) <=> H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide
REACT:R-HSA-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Homo sapiens)
REACT:R-RNO-5625959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Rattus norvegicus)
RHEA:24239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + trimethylamine <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide
GO:0004339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-amylase activity
GO:0004339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,4-alpha-glucosidase activity
GO:0004339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amyloglucosidase activity
GO:0004339	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysosomal alpha-glucosidase activity
GO:0004339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucoamylase activity
GO:0004339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-1,4-glucan glucohydrolase activity
GO:0004339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan 1,4-alpha-glucosidase activity
GO:0004339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-D-glucan glucohydrolase activity
GO:0004339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose amylase activity
RHEA:13824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + glutarate + O2 <=> (S)-2-hydroxyglutarate + CO2 + succinate
RHEA:32413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2R,4S)-isodihydrocarveol + NAD(+)
REACT:R-RNO-2130336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial proteolyis of Ii by aspartic proteases to lip22 (Rattus norvegicus)
RHEA:39953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol
GO:0102807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity
GO:0070180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25S rRNA binding
GO:0070180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	large ribosomal subunit rRNA binding
GO:0070180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LSU rRNA binding
REACT:R-SPO-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Schizosaccharomyces pombe)
REACT:R-SPO-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Schizosaccharomyces pombe)
RHEA:59930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose + H(+) + NADPH => erythritol + NADP(+)
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosamine-phosphate N-acetyltransferase activity
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosamine 6-phosphate N-acetyltransferase activity
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglucosamine transacetylase activity
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucosamine-6-P N-acetyltransferase activity
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine 6-phosphate acetylase activity
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglucosamine N-acetylase activity
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine-6-phosphate acetylase activity
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglucosamine acetylase activity
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Homo sapiens)
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosamine-6-phosphate synthase activity
GO:0004343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminodeoxyglucosephosphate acetyltransferase activity
REACT:R-GGA-265010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)
RHEA:72590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + ATP + CoA <=> (E)-sinapoyl-CoA + AMP + diphosphate
REACT:R-HSA-8871227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA4 (Homo sapiens)
REACT:R-RNO-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Rattus norvegicus)
RHEA:40402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)
RHEA:53470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol
REACT:R-RNO-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Rattus norvegicus)
REACT:R-BTA-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Bos taurus)
REACT:R-BTA-9688456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds FLOT1, FLOT2 (Bos taurus)
REACT:R-GGA-2213205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type XII and XIV collagens associate with type I and type II fibrils. (Gallus gallus)
RHEA:69356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hypobromite + L-tyrosyl-[protein] = 3-bromo-L-tyrosyl-[protein] + H2O
RHEA:61984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10
RHEA:18503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH => ergosterol + NADP(+)
REACT:R-DDI-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Dictyostelium discoideum)
REACT:R-RNO-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Rattus norvegicus)
RHEA:19300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-histidine <=> ADP + carnosine + H(+) + phosphate
REACT:R-HSA-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)
REACT:R-SSC-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Sus scrofa)
RHEA:24408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H(+) + H2O = inosine + NH4(+)
RHEA:56737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + retinal => H(+) + H2O2 + retinoate
REACT:R-GGA-112437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NELF complex  (Gallus gallus)
GO:0010303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextrin alpha-1,6-glucanohydrolase activity
GO:0010303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amylopectin-1,6-glucosidase activity
GO:0010303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrinase activity
GO:0010303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	R-enzyme
REACT:R-BTA-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
REACT:R-DRE-9020274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Danio rerio)
GO:0023027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class I protein binding, via antigen binding groove
GO:0042169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain binding
REACT:R-HSA-2465917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerisation of 11c-retinyl to at-retinyl (Homo sapiens)
RHEA:54626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octadecanoyl-CoA
REACT:R-MMU-6801776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A binds bacterial phospholipids (Mus musculus)
REACT:R-RNO-8938431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 and BTN1A1 binds periplakin (PPL) (Rattus norvegicus)
RHEA:59990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => cyclohexane-1-carbonyl-CoA + NADP(+)
RHEA:62892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + 2 H2O + nor-toralactone
RHEA:53002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate
REACT:R-DRE-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Danio rerio)
GO:0008378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Homo sapiens)
GO:0008378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosyltransferase activity
REACT:R-BTA-888589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GABA at the synapse (Bos taurus)
GO:0140796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R8 arginine deiminase activity
GO:0140796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3-R8 citrullination
GO:0140796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-R8 arginine deiminase activity
GO:0140796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine deiminase activity (H3-R8 specific)
RHEA:43025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteine => 2-aminoprop-2-enoate + a thiol
REACT:R-RNO-427656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:11366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + 2 H(+) + phosphate + phosphoenolpyruvate => ATP + H2O + pyruvate
RHEA:33485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + ergosteryl ester => an acyl-CoA + ergosterol
REACT:R-RNO-5610763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Rattus norvegicus)
REACT:R-DRE-9011952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Danio rerio)
REACT:R-RNO-9611851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 bind ADR,NAd (Rattus norvegicus)
GO:0005128	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	erythropoietin
GO:0005128	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	erythropoietin receptor ligand
GO:0005128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythropoietin receptor binding
RHEA:38498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + H2O <=> a 1,3-diacylglycerol + a fatty acid + H(+)
REACT:R-BTA-202245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TBSMs in LAT (Bos taurus)
REACT:R-BTA-193656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with RIP2 (Bos taurus)
REACT:R-GGA-202472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TRAF6 to CBM complex (Gallus gallus)
RHEA:24695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + NADP(+) + trans-isoeugenol => (E)-coniferyl acetate + NADPH
REACT:R-CFA-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Canis familiaris)
RHEA:68547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate
REACT:R-PFA-203680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:NOSIP translocation from caveolae to intracellular compartments (Plasmodium falciparum)
RHEA:71623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(out) + phosphate(in) = malonate(in) + phosphate(out)
RHEA:59101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diglucosyl-enterobactin + UDP-alpha-D-glucose => H(+) + triglucosyl-enterobactin + UDP
REACT:R-SCE-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)
GO:0004515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deamido-NAD(+) pyrophosphorylase activity
GO:0004515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate-nucleotide adenylyltransferase activity
GO:0004515	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nicotinic acid mononucleotide adenylyltransferase
GO:0004515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deamidonicotinamide adenine dinucleotide pyrophosphorylase activity
GO:0004515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deamido-NAD+ pyrophosphorylase activity
GO:0004515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NaMN-ATase activity
GO:0004515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate mononucleotide adenylyltransferase activity
GO:0004515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:nicotinate-nucleotide adenylyltransferase activity
GO:0004515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:nicotinate-ribonucleotide adenylyltransferase activity
GO:0004515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deamido-NAD(+) diphosphorylase activity
RHEA:62683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphtopyrone YWA1 <=> H(+) + H2O + norrubrofusarin
REACT:R-BTA-193508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Bos taurus)
RHEA:43461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA
REACT:R-DDI-9668419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Dictyostelium discoideum)
RHEA:66103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + L-kynurenine <=> H2O + kynurenate + L-tyrosine
GO:0047584	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalmesaconate hydratase activity
GO:0047584	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity
GO:0047584	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]
GO:0047584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxalmesaconate hydratase activity
GO:0047584	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxy-2-oxohexenedioate hydratase activity
GO:0047584	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-oxalmesaconate hydratase activity
GO:0047584	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity
REACT:R-HSA-5602186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP27B1 does not hydroxylate CDL (Homo sapiens)
REACT:R-BTA-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Bos taurus)
EC:2.4.1.362	skos:altLabel	"BRS-A"
EC:2.4.1.362	skos:altLabel	"branching sucrase A"
EC:2.4.1.362	skos:prefLabel	"alpha-(1->3) branching sucrase"
EC:2.4.1.362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-(1->3) branching sucrase"
REACT:R-DRE-9006850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor JAK phosphorylation (Danio rerio)
REACT:R-GGA-909552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 at Ser727 (Gallus gallus)
REACT:R-DDI-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Dictyostelium discoideum)
REACT:R-HSA-5577237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNH2:KCNE transport K+ from cytosol to extracellular region (Homo sapiens)
RHEA:26327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine => (8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine
GO:0098650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-proline 4-dioxygenase binding
REACT:R-DME-203565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Drosophila melanogaster)
RHEA:54150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene
REACT:R-HSA-4641147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DACT1 binds DVL2 (Homo sapiens)
RHEA:56447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate
RHEA:28259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate => cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP
REACT:R-XTR-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Xenopus tropicalis)
REACT:R-RNO-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Rattus norvegicus)
RHEA:69226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+) => a (Z)-alkenyl glucosinolate + H2O
REACT:R-SCE-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Saccharomyces cerevisiae)
RHEA:27665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + O2 <=> 2-oxoglutarate + H2O2
REACT:R-DRE-888589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GABA at the synapse (Danio rerio)
RHEA:30911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin + H2O = a carboxylate + sphing-4-enine-phosphocholine
RHEA:63632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-AMP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + H(+)
RHEA:36296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltose 6'-phosphate + H2O => D-maltose + phosphate
RHEA:41891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)
REACT:R-SSC-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Sus scrofa)
REACT:R-SSC-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Sus scrofa)
REACT:R-BTA-5333671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCAs self cleave (Bos taurus)
REACT:R-CEL-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)
REACT:R-MMU-211178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO1A is excluded from the nucleus (Mus musculus)
RHEA:51760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate
RHEA:37300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-threonine => L-alanine + L-threonine
REACT:R-DDI-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Dictyostelium discoideum)
RHEA:46637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrotestosterone + NADP(+) => H(+) + NADPH + testosterone
GO:0062082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLA-E specific inhibitory MHC class Ib receptor activity
REACT:R-SSC-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Sus scrofa)
RHEA:46717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine
RHEA:11870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose + H(+) + NADPH => D-arabinitol + NADP(+)
REACT:R-CEL-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Caenorhabditis elegans)
RHEA:42185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH
REACT:R-GGA-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Gallus gallus)
RHEA:28138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + streptothricin F = streptothricin F acid
REACT:R-MMU-3296233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T2Rs bind bitter-tasting compounds (Mus musculus)
GO:0047931	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminodeoxyglucose kinase activity
GO:0047931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosamine kinase activity
GO:0047931	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity
GO:0047931	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-glucosamine phosphotransferase activity
GO:0047931	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine kinase (phosphorylating)
REACT:R-PFA-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)
REACT:R-BTA-1168644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Bos taurus)
RHEA:28170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aliphatic (R)-hydroxynitrile lyase"
RHEA:28170	skos:prefLabel	"aliphatic (R)-hydroxynitrile lyase"
RHEA:28170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide
RHEA:28170	skos:altLabel	"(R)-hydroxynitrile lyase"
RHEA:28170	skos:altLabel	"(R)-oxynitrilase"
REACT:R-CFA-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)
REACT:R-XTR-2066779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Xenopus tropicalis)
REACT:R-HSA-9673789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNK phosphorylates c-JUN (Homo sapiens)
REACT:R-CFA-5624954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INPP5E translocates to the primary cilium (Canis familiaris)
REACT:R-DME-6809680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTM1 (Drosophila melanogaster)
REACT:R-HSA-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)
RHEA:22774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-fuconate + H2O => L-fuconate
RHEA:39580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O
REACT:R-BTA-5205799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Bos taurus)
RHEA:15540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate + NADP(+) <=> 3-sulfopyruvate + H(+) + NADPH
REACT:R-BTA-5228521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Bos taurus)
REACT:R-DRE-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Danio rerio)
REACT:R-MMU-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Mus musculus)
REACT:R-GGA-2129375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin cross-linking by lysyl oxidase (Gallus gallus)
RHEA:64829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + acetyl-CoA => 3-hydroxy-benzyl acetate + CoA
GO:0033973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dCTP deaminase (dUMP-forming)"
GO:0033973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP deaminase (dUMP-forming) activity
GO:0033973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dCTP aminohydrolase (dUMP-forming) activity
GO:0033973	skos:prefLabel	"dCTP deaminase (dUMP-forming)"
GO:0033973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + 2 H2O = diphosphate + dUMP + NH4(+)
REACT:R-DDI-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Dictyostelium discoideum)
REACT:R-HSA-5333678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPNEs bind PL (Homo sapiens)
RHEA:24060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]
RHEA:37780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-CEL-77254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Caenorhabditis elegans)
GO:1902314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone binding
GO:1902314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinol binding
REACT:R-DRE-8851018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A1 binds DC-SIGN (Danio rerio)
RHEA:42522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(2605) in 23S rRNA => uridine(2605) in 23S rRNA
REACT:R-CEL-111746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Caenorhabditis elegans)
RHEA:58561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate II + NADP(+) => 15alpha-stemmadenine intermediate I + NADPH
RHEA:11581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)
RHEA:47970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + N-acetyl-beta-D-galactosamine => ganglioside GM2 + H2O
RHEA:23607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kievitone hydrate <=> H2O + kievitone
RHEA:31241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 CO2 + coproporphyrinogen I => 4 H(+) + uroporphyrinogen I
REACT:R-HSA-211950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 24-hydroxylates CTL (Homo sapiens)
RHEA:35501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-8848751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds AKT1 (Homo sapiens)
REACT:R-RNO-379426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Rattus norvegicus)
REACT:R-XTR-2730894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB1:RELA translocates from the cytosol to the nucleus (Xenopus tropicalis)
REACT:R-CFA-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Canis familiaris)
REACT:R-CEL-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Caenorhabditis elegans)
REACT:R-BTA-5626220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 binds the mother centriole (Bos taurus)
RHEA:16986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate + NADP(+) => H(+) + maleylacetate + NADPH
REACT:R-BTA-354087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2 to p-PTK2 (Bos taurus)
REACT:R-DME-1655851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2P hydrolyzes SREBP1A,1C,2 (Drosophila melanogaster)
REACT:R-MMU-5654679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR3 (Mus musculus)
RHEA:22500	skos:altLabel	"phenylpropanoyl-diketide-CoA synthase"
RHEA:22500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + H(+) + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA
RHEA:22500	skos:prefLabel	"phenylpropanoylacetyl-CoA synthase"
RHEA:22500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylpropanoylacetyl-CoA synthase"
RHEA:22500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H(+) + malonyl-CoA = (E)-feruloylacetyl-CoA + CO2 + CoA
RHEA:68130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid phytyl ester + CoA => a fatty acyl-CoA + phytol
REACT:R-SSC-201422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Sus scrofa)
RHEA:41619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 2,5-bisphosphate + H2O <=> D-ribose 5-phosphate + phosphate
RHEA:59114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-serine => ATP + L-serine
RHEA:38754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate
REACT:R-DME-392748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds to AP-2 Clathrin complex (Drosophila melanogaster)
REACT:R-GGA-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Gallus gallus)
REACT:R-SCE-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)
REACT:R-HSA-1483096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA is dephosphorylated to ETA by PHOSPHO1 (Homo sapiens)
REACT:R-XTR-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Xenopus tropicalis)
RHEA:20872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + UDP-alpha-D-glucose = (20S)-ginsenoside Rb1 + H(+) + UDP
RHEA:20872	skos:prefLabel	"ginsenoside Rd glucosyltransferase"
RHEA:20872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ginsenoside Rd glucosyltransferase"
REACT:R-GGA-187617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Gallus gallus)
REACT:R-MMU-8847977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRK phosphorylates PTEN (Mus musculus)
REACT:R-BTA-8964605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Bos taurus)
REACT:R-HSA-5635845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind CDC73 (Homo sapiens)
REACT:R-MMU-4084978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Mus musculus)
RHEA:69756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzyl)malonyl-CoA + H(+) + O2 => (E)-2-aminocinnamoyl-CoA + CO2 + H2O2
REACT:R-MMU-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
REACT:R-HSA-5578717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDIN3D dimethylates 5' phosphate of pre-miR-145 (Homo sapiens)
REACT:R-CFA-375140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds promyogenic cadherins (Canis familiaris)
RHEA:69288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate = sulfate + sulforaphane
GO:0004436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol diacylglycerol-lyase activity
GO:0004436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)
GO:0004436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)
GO:0004436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)
GO:0004436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol phosphodiesterase activity
GO:0004436	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	monophosphatidylinositol phosphodiesterase activity
REACT:R-DDI-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Dictyostelium discoideum)
RHEA:52729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate => a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SSC-111237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR1 homodimer (Sus scrofa)
RHEA:32486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + pheophorbide a <=> CO2 + methanol + pyropheophorbide a
REACT:R-MMU-2396029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-3 binds integrins (Mus musculus)
RHEA:21501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose => H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose
RHEA:22605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose => D-fructose
REACT:R-MMU-3900070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MKL1 with SUMO1 (Mus musculus)
REACT:R-HSA-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Homo sapiens)
REACT:R-HSA-9657051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta G12E does not translocate to mitochondria (Homo sapiens)
REACT:R-BTA-4093329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SDCBP (Bos taurus)
GO:0038147	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CXCR4
GO:0038147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stromal cell-derived factor-1 receptor activity
GO:0038147	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CXCR7
GO:0038147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-X-C motif chemokine 12 receptor activity
GO:0038147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCL12 receptor activity
GO:0038147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SDF-1 receptor activity
REACT:R-DDI-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Dictyostelium discoideum)
RHEA:69925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => castasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:54979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanoyl-CoA + H2O <=> (3S)-hydroxytetradecanoate + CoA + H(+)
REACT:R-BTA-1679098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Bos taurus)
REACT:R-BTA-8953418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 complex binds E2F6.com-1 core (Bos taurus)
RHEA:12618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-alpha-D-galactosamine => ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate
RHEA:46506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + dodecanoyl-[ACP] + H(+) => dodecanoyl-AMP + holo-[ACP]
RHEA:18170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate
REACT:R-HSA-8981657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds PTPRZ1 (Homo sapiens)
REACT:R-SSC-8983835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Sus scrofa)
RHEA:53635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (3S)-(+)-asterisca-2(9),6-diene + diphosphate
REACT:R-XTR-448632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimerizes (Xenopus tropicalis)
GO:0102111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity
REACT:R-SSC-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Sus scrofa)
REACT:R-XTR-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Xenopus tropicalis)
REACT:R-BTA-183084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Bos taurus)
GO:0050326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxifolin hydroxylase activity
GO:0050326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)
GO:0050326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxifolin 8-monooxygenase activity
GO:0050326	skos:prefLabel	"taxifolin 8-monooxygenase"
GO:0050326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taxifolin 8-monooxygenase"
REACT:R-MMU-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Mus musculus)
REACT:R-HSA-3000399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates SP100 with SUMO1 (Homo sapiens)
REACT:R-CEL-5577234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Caenorhabditis elegans)
REACT:R-BTA-5622134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRABP1 binds atRA (Bos taurus)
REACT:R-CFA-109387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Canis familiaris)
RHEA:34826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + curcumin
RHEA:39460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)
RHEA:11995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate + O2 <=> H(+) + H2O2 + L-1-piperideine-6-carboxylate
RHEA:38663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)
REACT:R-DRE-397835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:Gq (active) dissociate (Danio rerio)
REACT:R-HSA-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Homo sapiens)
REACT:R-RNO-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Rattus norvegicus)
REACT:R-CFA-3640844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 binds RibC-AXIN:TNKS complex (Canis familiaris)
RHEA:19925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 5-phosphate + NAD(+) = D-ribulose 5-phosphate + H(+) + NADH
REACT:R-DRE-429955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR4-NOT complex deadenylates mRNA (Danio rerio)
REACT:R-BTA-158145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Bos taurus)
RHEA:50807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin J2 <=> prostaglandin J2-S-(R)-glutathione
REACT:R-BTA-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Bos taurus)
RHEA:61532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:14182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 => (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate
RHEA:57219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-dGTP
RHEA:56467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
RHEA:63850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3',4'-dihydroxyaurone + 2 H2O => 2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2
REACT:R-HSA-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Homo sapiens)
RHEA:63285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-XTR-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Xenopus tropicalis)
RHEA:31552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	presqualene diphosphate => 15-cis-4,4'-diapophytoene + diphosphate
RHEA:71103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) + S-methylmercury-L-cysteine(out) = L-methionine(out) + S-methylmercury-L-cysteine(in)
RHEA:65769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0003697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ssDNA binding
GO:0003697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded DNA binding
REACT:R-HSA-1793207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses C4S/C6S chains (Homo sapiens)
REACT:R-DRE-5362549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np traffics to the plasma membrane (Danio rerio)
GO:0140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',2'-cyclic GAMP synthase activity
GO:0140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',2' cyclic-GMP-AMP synthase activity
GO:0140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',2'-cyclic GMP-AMP synthase activity
RHEA:14910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonate + NADP(+) => aldehydo-D-glucuronate + H(+) + NADPH
GO:0035485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A/G mispair binding
GO:0035485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine/guanine mispair binding
GO:0035485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine-adenine mispair binding
GO:0035485	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	G/A mispair binding
REACT:R-HSA-390470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)
REACT:R-BTA-8865182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7A hydrolyses K11diUb (Bos taurus)
REACT:R-DRE-1028816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Danio rerio)
GO:0035727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA binding
GO:0035727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophosphatidic acid binding
REACT:R-BTA-4332363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation and activation of CAMK2 (Bos taurus)
REACT:R-BTA-191072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Cx43 (Bos taurus)
RHEA:10166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphoenolpyruvate => (2R)-2-phosphoglycerate
RHEA:58779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pyridine 3-methanol <=> H(+) + NADPH + pyridine-3-carbaldehyde
REACT:R-DRE-8951486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C4b (Danio rerio)
RHEA:40616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tridecanoylglycerol => 2,3-didecanoyl-sn-glycerol + decanoate + H(+)
RHEA:20587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin => loganin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:53143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
GO:0034511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U3 snoRNA binding
REACT:R-DME-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Drosophila melanogaster)
GO:0008832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTPase activity
GO:0008832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyguanosine 5-triphosphate triphosphohydrolase activity
GO:0008832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyguanosine triphosphatase activity
GO:0008832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dGTP triphosphohydrolase activity
GO:0008832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxy-GTPase activity
GO:0008832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyguanosinetriphosphate triphosphohydrolase activity
GO:0008832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyguanosine triphosphate triphosphohydrolase activity
REACT:R-MMU-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Mus musculus)
RHEA:29605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin]
RHEA:35812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (-)-medicarpin + H2O
REACT:R-DME-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Drosophila melanogaster)
RHEA:18011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein] => glutaryl-CoA + L-lysyl-[protein]
GO:0031593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyubiquitin modification-dependent protein binding
REACT:R-MMU-166168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Mus musculus)
RHEA:38878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2604) in 23S rRNA <=> pseudouridine(2604) in 23S rRNA
REACT:R-CEL-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Caenorhabditis elegans)
REACT:R-SSC-9024993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Sus scrofa)
REACT:R-DDI-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Dictyostelium discoideum)
RHEA:62236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine(6-4)cytidine in DNA = a cytidine dimer in DNA + H(+)
REACT:R-DRE-75079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC C complex (Danio rerio)
RHEA:22382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol => [(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O
RHEA:32725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:25003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-phenylalanine <=> (E)-phenylacetaldehyde oxime + CO2 + H2O
REACT:R-MMU-8943987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCUBE1, SCUBE3 oligomerize (Mus musculus)
RHEA:29292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oate + ATP + CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate
RHEA:32306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-homocitrate <=> (2R,3S)-homoisocitrate
REACT:R-HSA-8983374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)
RHEA:53047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Drosophila melanogaster)
RHEA:53641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-alpha-amorphene + diphosphate
RHEA:12382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + L-aspartate 4-semialdehyde => L-2,4-diaminobutanoate + pyruvate
RHEA:69940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-917888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF binds 2Fe3+ to form holoTF (Mus musculus)
REACT:R-CFA-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Canis familiaris)
REACT:R-DME-9033509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5L (Drosophila melanogaster)
RHEA:20112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,5-bisphosphate + ATP <=> 5-phospho-alpha-D-ribose 1-diphosphate + ADP
REACT:R-CEL-1306965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Caenorhabditis elegans)
REACT:R-CEL-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Caenorhabditis elegans)
RHEA:22344	skos:prefLabel	"rosmarinate synthase"
RHEA:22344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rosmarinate synthase"
RHEA:22344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA = (R)-rosmarinate + CoA
RHEA:18681	skos:altLabel	"pyruvic-uridine diphospho-N-acetylglucosaminyltransferase"
RHEA:18681	skos:altLabel	"pyruvate-uridine diphospho-N-acetyl-glucosamine transferase"
RHEA:18681	skos:altLabel	"phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase"
RHEA:18681	skos:altLabel	"UDP-N-acetylglucosamine enoylpyruvyltransferase"
RHEA:18681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine 1-carboxyvinyltransferase"
RHEA:18681	skos:prefLabel	"UDP-N-acetylglucosamine 1-carboxyvinyltransferase"
RHEA:18681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
RHEA:18681	skos:altLabel	"phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase"
RHEA:18681	skos:altLabel	"pyruvate-UDP-acetylglucosamine transferase"
RHEA:18681	skos:altLabel	"UDP-N-acetylglucosamine 1-carboxyvinyl-transferase"
RHEA:18681	skos:altLabel	"pyruvate-uridine diphospho-N-acetylglucosamine transferase"
RHEA:18681	skos:altLabel	"MurA transferase"
RHEA:18681	skos:altLabel	"enoylpyruvate transferase"
REACT:R-DDI-1482696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Dictyostelium discoideum)
REACT:R-CFA-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Canis familiaris)
REACT:R-SSC-9701524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated downstream of active ALK (Sus scrofa)
REACT:R-RNO-8942575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Rattus norvegicus)
REACT:R-XTR-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Xenopus tropicalis)
REACT:R-HSA-190662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in Trans-Golgi Network (TGN) (Homo sapiens)
RHEA:51913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate
REACT:R-SCE-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Saccharomyces cerevisiae)
REACT:R-SSC-8858346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMHR2 binds AMH (Sus scrofa)
RHEA:61231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidine + O2 <=> 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)
REACT:R-DME-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Drosophila melanogaster)
REACT:R-HSA-1605723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Homo sapiens)
REACT:R-CFA-9630923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B inhibitor binds NF-kappa-B complex (Canis familiaris)
REACT:R-CFA-8981657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds PTPRZ1 (Canis familiaris)
REACT:R-BTA-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Bos taurus)
REACT:R-HSA-981832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMUR2 binds neuromedin-S (Homo sapiens)
GO:0047569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate CoA-transferase activity
GO:0047569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoadipate coenzyme A-transferase activity
GO:0047569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoadipate succinyl-CoA transferase activity
GO:0047569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoadipate:succinyl-CoA transferase activity
GO:0047569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:3-oxoadipate CoA-transferase activity
RHEA:55987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile + UDP-alpha-D-glucose <=> (R)-prunasin + H(+) + UDP
RHEA:48952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH
GO:0008959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate acetyltransferase activity
GO:0008959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotransacetylase activity
GO:0008959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:phosphate acetyltransferase activity
GO:0008959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTA
GO:0008959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoacylase activity
REACT:R-SSC-5252041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Sus scrofa)
REACT:R-RNO-5252072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AZGP1 binds PIP (Rattus norvegicus)
RHEA:52561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-erythronate => 3-dehydro-D-erythronate
REACT:R-MMU-2484965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII binds Integrin alpha1beta1 (Mus musculus)
REACT:R-PFA-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Plasmodium falciparum)
GO:0015505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uracil permease activity
GO:0015505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil:cation symporter activity
REACT:R-DME-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Drosophila melanogaster)
RHEA:35337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoheptadecanoyl-CoA + CO2 + CoA => H(+) + isopentadecanoyl-CoA + malonyl-CoA
RHEA:50425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + 2 O2 => prostaglandin G1
REACT:R-CEL-158849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phenol can form a sulfate conjugate (Caenorhabditis elegans)
REACT:R-HSA-9674563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 (Homo sapiens)
RHEA:11463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glucose <=> AMP + D-glucose 6-phosphate + H(+)
REACT:R-SSC-5655193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIAA0101 double monoubiquitination (Sus scrofa)
REACT:R-SSC-183072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR non-clathrin mediated endocytosis (Sus scrofa)
RHEA:36757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose
REACT:R-GGA-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Gallus gallus)
RHEA:10033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal-L-glutamine + H2O => [protein]-C-terminal-L-glutamate + NH4(+)
REACT:R-CEL-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Caenorhabditis elegans)
RHEA:52907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,17(3)-seco-F430-17(3)-acid + ATP <=> ADP + coenzyme F430 + phosphate
GO:0004992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	platelet activating factor receptor activity
GO:0004992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF receptor activity
REACT:R-CEL-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)
REACT:R-GGA-5676599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF trimer binds BAFFR (Gallus gallus)
RHEA:51310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl-[F-actin] + NADPH + O2
RHEA:49140	skos:prefLabel	"dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase"
RHEA:49140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase"
RHEA:49140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:49140	skos:altLabel	"TDP-4-keto-2,6-dideoxy-D-glucose 3-dehydrase"
REACT:R-CFA-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Canis familiaris)
GO:0009024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)
GO:0009024	skos:altLabel	"Phosphotagatokinase"
GO:0009024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotagatokinase activity
GO:0009024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-tagatose-6-phosphate 1-phosphotransferase activity
GO:0009024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tagatose-6-phosphate kinase activity
GO:0009024	skos:prefLabel	"tagatose-6-phosphate kinase"
GO:0009024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tagatose-6-phosphate kinase"
RHEA:14794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyadipate + NAD(+) => 2-oxoadipate + H(+) + NADH
RHEA:60818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A14 + H(+) + succinate => 2-oxoglutarate + gibberellin A14 aldehyde + O2
REACT:R-HSA-9026493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y516 of p-5Y-NTRK2 recruits SHC1 (Homo sapiens)
REACT:R-SSC-5229132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 binds APP (Sus scrofa)
RHEA:36475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA
REACT:R-HSA-5693604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XRCC4:LIG4 ligates DNA DSB ends during NHEJ (Homo sapiens)
RHEA:22873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[collagen] + O2 => CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]
REACT:R-MMU-5687758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP4C:PPP4R2 dephosphorylates RPA2 (Mus musculus)
REACT:R-XTR-9701524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated downstream of active ALK (Xenopus tropicalis)
REACT:R-XTR-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Xenopus tropicalis)
RHEA:47271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacterioruberin <=> H2O + monoanhydrobacterioruberin
REACT:R-HSA-392187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)
RHEA:26153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil => 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate
RHEA:36039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH
REACT:R-HSA-8938034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR4A3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
RHEA:36517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexacosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetracosanoyl-CoA
REACT:R-HSA-77594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)
REACT:R-XTR-5676597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Xenopus tropicalis)
REACT:R-CFA-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Canis familiaris)
RHEA:43547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tyramine <=> ADP + gamma-L-glutamyltyramine + H(+) + phosphate
RHEA:70819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
REACT:R-BTA-4088141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PPP2R2A dephosphorylates FOXM1 (Bos taurus)
RHEA:54443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4S)-2,3-dehydroflavan-3,4-diol + H(+) <=> a 4-H-anthocyanidin with a 3-hydroxy group + H2O
REACT:R-CFA-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Canis familiaris)
RHEA:20623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + Zn(2+)(out) => ATP + H2O + Zn(2+)(in)
RHEA:22026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + trimethylamine N-oxide => H2O + NAD(+) + trimethylamine
REACT:R-BTA-376122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM/DSCAML1 homodimerization (Bos taurus)
REACT:R-XTR-5692781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Xenopus tropicalis)
RHEA:52170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:34448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-beta-L-talose + NAD(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH
RHEA:67246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH => 3-deoxyglucosone + H2O + NAD(+)
RHEA:12639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose
GO:0019787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conjugating protein transferase activity
GO:0019787	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin-like conjugating enzyme activity
GO:0019787	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	small conjugating protein ligase activity
GO:0019787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 is K63 polyubiquitinated (Homo sapiens)
GO:0019787	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	small protein conjugating enzyme activity
GO:0019787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0019787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein transferase activity
GO:0019787	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin-like-protein ligase activity
GO:0019787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Homo sapiens)
GO:0019787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
REACT:R-HSA-202510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1-TAB2 complex (Homo sapiens)
RHEA:43710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + hexadecanoyl-AMP => ATP + H(+) + hexadecanoate
REACT:R-CFA-189208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Canis familiaris)
REACT:R-MMU-5654659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)
REACT:R-HSA-9619542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)
RHEA:11926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose
RHEA:57760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
GO:0004110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"corticosteroid side-chain-isomerase"
GO:0004110	skos:prefLabel	"corticosteroid side-chain-isomerase"
GO:0004110	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	11-deoxycorticosterone ketol-isomerase activity
GO:0004110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosteroid side-chain-isomerase activity
GO:0004110	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	11-deoxycorticosterone aldose-ketose-isomerase activity
GO:0004110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone = 20-hydroxy-3-oxopregn-4-en-21-al
REACT:R-MMU-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Mus musculus)
REACT:R-DDI-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)
RHEA:45362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoate + sphinganine => H2O + N-(11Z-eicosenoyl)-sphinganine
RHEA:16669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + xanthine = H(+) + NADH + urate
REACT:R-GGA-265858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATR by interaction with RAD9-TopBP1 complex (Gallus gallus)
REACT:R-DME-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Drosophila melanogaster)
RHEA:40005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-biformene + diphosphate => ent-copalyl diphosphate
REACT:R-DME-5610720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI3 (Drosophila melanogaster)
REACT:R-SSC-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Sus scrofa)
REACT:R-XTR-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Xenopus tropicalis)
REACT:R-PFA-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Plasmodium falciparum)
REACT:R-DRE-5695989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD11 dehydrogenates BH-CoA (Danio rerio)
REACT:R-SSC-9700121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN,MDK):PTPRZ oligomerizes (Sus scrofa)
RHEA:69754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylmalonyl-CoA + H(+) + O2 <=> (E)-cinnamoyl-CoA + CO2 + H2O2
REACT:R-GGA-8856189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF8 binds TNFRSF8 (Gallus gallus)
GO:1903264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate reductase activity involved in anaerobic electron transport chain
GO:1903264	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	respiratory nitrate reductase activity involved in anaerobic electron transport chain
GO:1903264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite:(acceptor) oxidoreductase involved in anaerobic electron transport chain
GO:1903264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate reductase (acceptor) involved in anaerobic electron transport chain
GO:1903264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite:acceptor oxidoreductase involved in anaerobic electron transport chain
RHEA:54106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
REACT:R-XTR-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Xenopus tropicalis)
REACT:R-HSA-5649708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 recruits POLB to incised AP site (Homo sapiens)
REACT:R-RNO-8937419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBR3 reduces DOX to DOXOL (Rattus norvegicus)
REACT:R-HSA-8848247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD4,5 bind MCFA-CoA and LCFA-CoA (Homo sapiens)
REACT:R-CFA-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Canis familiaris)
RHEA:47381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]
REACT:R-DRE-5610725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TULP3 is required for GPR161 localization in the cilium (Danio rerio)
REACT:R-MMU-265301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticotropin cleavage from POMC (Mus musculus)
RHEA:56831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6-trichlorohydroquinone + chloride + glutathione disulfide <=> 2,3,5,6-tetrachlorohydroquinone + 2 glutathione
RHEA:72448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate(in) + estrone 3-sulfate(out) => a dicarboxylate(out) + estrone 3-sulfate(in)
GO:0004955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin receptor activity
REACT:R-HSA-9685655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTSL bind CTSL inhibitors (Homo sapiens)
RHEA:37755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-MMU-8873834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 transports PC from ER membrane to lamellar body membrane (Mus musculus)
RHEA:14780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + H2O <=> IMP + NH4(+)
REACT:R-XTR-3132753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pancreatic proteases degrade TCN1:RCbl (Xenopus tropicalis)
RHEA:65558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc => globoside GalGb4Cer + H2O
RHEA:13795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylene-3-methylsuccinate => 2-methyleneglutarate
REACT:R-SSC-9668419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Sus scrofa)
REACT:R-DDI-4551768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO2,3 (Dictyostelium discoideum)
REACT:R-DME-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Drosophila melanogaster)
REACT:R-MMU-5357429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL autophosphorylates on Y772 and Y814 (Mus musculus)
GO:0004790	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity
GO:0004790	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thioether methyltransferase activity
GO:0004790	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:thioether S-methyltransferase activity
GO:0004790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioether S-methyltransferase activity
RHEA:42843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH <=> 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)
GO:0140440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]
GO:0140440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-cysteine S-oleoyltransferase activity
REACT:R-DDI-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Dictyostelium discoideum)
RHEA:70752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
GO:0038102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activin receptor antagonist activity
REACT:R-RNO-983285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B binds RAD51C (Rattus norvegicus)
REACT:R-HSA-5654515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds HS (Homo sapiens)
RHEA:51818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out)
RHEA:11041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
REACT:R-CEL-77301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Caenorhabditis elegans)
GO:0070611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-R2 specific)
GO:0070611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H3-R2 specific)
GO:0070611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine N-methyltransferase activity (H3-R2 specific)
GO:0070611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R2 arginine methyltransferase activity
GO:0070611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3R2 methyltransferase activity
GO:0070611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R2 methyltransferase activity
REACT:R-MMU-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Mus musculus)
REACT:R-CEL-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Caenorhabditis elegans)
GO:0052896	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	spermidine:(acceptor) oxidoreductase activity
GO:0052896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine oxidase (propane-1,3-diamine-forming) activity
GO:0052896	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyamine oxidase (propane-1,3-diamine-forming) activity
REACT:R-MMU-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Mus musculus)
REACT:R-HSA-9010091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APP translocates from plasma membrane to endosome lumen (Homo sapiens)
RHEA:64801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + S-(2-aminoethyl)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)
RHEA:49002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2
REACT:R-MMU-8987255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Mus musculus)
REACT:R-MMU-1237045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Mus musculus)
RHEA:68037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cystathionine ketimine + 2 H(+) + NADPH => (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)
REACT:R-DDI-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Dictyostelium discoideum)
REACT:R-RNO-9026777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)
REACT:R-HSA-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Homo sapiens)
RHEA:72578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O <=> (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA
REACT:R-SSC-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Sus scrofa)
REACT:R-MTU-879319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-inositol and cysteine are ligated to desacetylmycothiol (Mycobacterium tuberculosis)
RHEA:41593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)
RHEA:10863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)
REACT:R-CFA-3240957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PRC2-EZH2 complex (Canis familiaris)
REACT:R-SCE-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
RHEA:41468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]
RHEA:41468	skos:prefLabel	"oryzalexin E synthase"
RHEA:41468	skos:altLabel	"CYP76M6"
RHEA:41468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oryzalexin E synthase"
RHEA:23374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate
REACT:R-XTR-2197697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Xenopus tropicalis)
REACT:R-CFA-5607747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MALT1 oligomers (Canis familiaris)
REACT:R-HSA-1667005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Homo sapiens)
REACT:R-DME-400204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds RXRA (Drosophila melanogaster)
RHEA:39774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Homo sapiens)
REACT:R-CEL-3232162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates MITF with SUMO1 (Caenorhabditis elegans)
RHEA:63989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-thiocytidine + ATP => 2-thiocytidine 5'-phosphate + ADP + H(+)
RHEA:52456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP
RHEA:66051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-kynurenine <=> (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate
REACT:R-XTR-9627107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP7 (Xenopus tropicalis)
RHEA:22602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-9-O-acetylneuraminate
REACT:R-HSA-4085020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic Neu5Ac translocates to nucleus (Homo sapiens)
RHEA:67318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine => (2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine
RHEA:41241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2
RHEA:28761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+) => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose
REACT:R-HSA-6814153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADO oxidises 2AET to HTAU (Homo sapiens)
REACT:R-HSA-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Homo sapiens)
REACT:R-CFA-9663492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL dissociates from GSTA1, FABP1 (Canis familiaris)
RHEA:14220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]
RHEA:72400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + estrone 3-sulfate(in) => 2-oxoglutarate(in) + estrone 3-sulfate(out)
REACT:R-RNO-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)
GO:0052581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-cis-isopulegone:NADP+ oxidoreductase activity
GO:0052581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-isopiperitenone reductase activity
RHEA:72764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A10 + malonyl-CoA => anthocyanin A11 + CoA
RHEA:22552	skos:prefLabel	"alcohol sulfotransferase"
RHEA:22552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol sulfotransferase"
RHEA:22552	skos:altLabel	"hydroxysteroid sulfotransferase"
RHEA:22552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)
RHEA:34922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine(in) <=> thiamine(out)
REACT:R-MMU-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Mus musculus)
RHEA:50363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile + O2 <=> benzoyl cyanide + H2O2
RHEA:53755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP
RHEA:18776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] <=> Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-BTA-983285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B binds RAD51C (Bos taurus)
REACT:R-SSC-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Sus scrofa)
RHEA:24273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 => H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)
RHEA:70208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-4E,14Z-dienine-1-phosphate(in) => sphinga-4E,14Z-dienine-1-phosphate(out)
RHEA:16258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + phosphate => alpha-D-glucose + alpha-D-glucose 1-phosphate
REACT:R-MMU-8954082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds the PRC1 complex (Mus musculus)
RHEA:24174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5beta-steroid
EC:4.2.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on phosphates"
EC:4.2.3.-	skos:prefLabel	"Acting on phosphates"
RHEA:28039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dCDP + H2O => [thioredoxin]-dithiol + CDP
REACT:R-DRE-8849055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARHGAP35 (Danio rerio)
REACT:R-HSA-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)
REACT:R-CEL-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Caenorhabditis elegans)
REACT:R-MMU-163843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-GAS6 to GAS6 (Mus musculus)
RHEA:20915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + taxa-4,11-diene
GO:0009007	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	modification methylase activity
GO:0009007	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-6 adenine-specific DNA methylase activity
GO:0009007	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	EcoRI methylase
GO:0009007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	site-specific DNA-methyltransferase (adenine-specific) activity
GO:0009007	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA adenine methylase
GO:0009007	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	restriction-modification system activity
REACT:R-DDI-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Dictyostelium discoideum)
RHEA:19403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H(+) + NADH => methanol + NAD(+)
RHEA:35790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	paromamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin C + UDP
REACT:R-CFA-3788075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by ADAMTS4, ADAMTS5 (Canis familiaris)
REACT:R-GGA-265973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of FANCI (Gallus gallus)
RHEA:49441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA => (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate
REACT:R-XTR-433711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-homodimerization of nectins (Xenopus tropicalis)
REACT:R-SPO-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)
RHEA:21282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O2 + thiamine acetate => H2O + 2 O2 + thiamine
REACT:R-HSA-9011958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-26A and B bind to the 3'UTR of the GREB1 mRNA (Homo sapiens)
REACT:R-GGA-2029453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of VAV (Gallus gallus)
RHEA:17118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + methylamine => ADP + H(+) + N(5)-methyl-L-glutamine + phosphate
REACT:R-DDI-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)
RHEA:60504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)
RHEA:61058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:30764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-valine + NAD(+) => 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)
RHEA:57116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:32873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + glycerol + H(+) => a 2-acylglycerol + H2O
RHEA:35056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichlorocatechol + O2 => (2E,4E)-2,5-dichloromuconate + H(+)
RHEA:31566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene C4 <=> L-glutamate + leukotriene D4
REACT:R-HSA-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)
REACT:R-CFA-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Canis familiaris)
RHEA:25155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-phenylalanine <=> 3-phenylpyruvate + L-glutamate
REACT:R-DME-2197691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIP binds WASP,N-WASP, activating them (Drosophila melanogaster)
REACT:R-MMU-391375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Mus musculus)
RHEA:69781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-oxoindol-3-yl)acetyl-CoA + succinate => 2-oxindole-3-acetate + succinyl-CoA
GO:0106243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syn-isopimara-7,15-diene synthase activity
GO:0106243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene
REACT:R-DRE-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Danio rerio)
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ras superfamily protein
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling G protein activity
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heterotrimeric G-protein GTPase activity
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	small GTPase
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	large G-protein activity
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	small G-protein
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	small monomeric GTPase activity
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	small GTPase activity
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	small monomeric G protein activity
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	large G-protein GTPase activity
GO:0003925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein activity
REACT:R-MMU-9008258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 binds ESR1:estrogen:TFGA gene (Mus musculus)
REACT:R-DRE-83793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Danio rerio)
RHEA:51050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + androst-4-ene-3,17-dione => 5alpha-androstan-3,17-dione + A
RHEA:46127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-751019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:G12/13 complex dissociates (Mus musculus)
REACT:R-HSA-168894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Accumulation of M1 at the inner leaflet of the lipid bilayer (Homo sapiens)
RHEA:50026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine => dodecanoyl-CoA + H2O
RHEA:25179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + CO2 + NADH => 4-methyl-2-oxopentanoate + CoA + NAD(+)
REACT:R-HSA-9684290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3 is glycosylated (Homo sapiens)
RHEA:16974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxypyridine + AH2 + O2 => 2,5-dihydroxypyridine + A + H2O
RHEA:66846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Danio rerio)
REACT:R-RNO-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Rattus norvegicus)
RHEA:35686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecasphinganine + NADP(+) <=> 3-oxohexadecasphinganine + H(+) + NADPH
REACT:R-MMU-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Mus musculus)
REACT:R-CFA-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
RHEA:47412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA
RHEA:12435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine
RHEA:59885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chloride + H(+) + L-lysine + O2 => 4-chloro-L-lysine + CO2 + H2O + succinate
REACT:R-RNO-9761344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 binds IKBKG within IKK complex (Rattus norvegicus)
REACT:R-SCE-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)
REACT:R-DRE-381612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1 (Danio rerio)
REACT:R-GGA-750993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (q) reassociates with G beta:gamma (Gallus gallus)
REACT:R-HSA-2396002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Homo sapiens)
RHEA:52529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparagine => 2-oxosuccinamate + L-glutamate
REACT:R-DRE-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Danio rerio)
RHEA:55738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose
RHEA:25145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + H(+) + L-alanine => 3-hydroxy-L-kynurenine + H2O
RHEA:30720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + propanoyl-CoA => 2-methyl-3-oxobutanoyl-CoA + CoA
GO:0036185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-lipoxin reductase activity
GO:0036185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15k-LXA4 is reduced to dhk-LXA4 by PTGR1 (Homo sapiens)
RHEA:54135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)
REACT:R-GGA-914182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 zeta binding allows recruitment of PI3K (Gallus gallus)
REACT:R-SSC-2129385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFAP2, MFAP5 bind microfibrils (Sus scrofa)
RHEA:34528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine => (S)-3-amino-3-phenylpropanoate
REACT:R-DME-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Drosophila melanogaster)
RHEA:58051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA <=> 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA
REACT:R-DME-508308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Drosophila melanogaster)
RHEA:34695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = Delta(6)-protoilludene + diphosphate
RHEA:34695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Delta(6)-protoilludene synthase"
RHEA:34695	skos:altLabel	"6-protoilludene synthase"
RHEA:34695	skos:prefLabel	"Delta(6)-protoilludene synthase"
RHEA:20706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-D-amino acid + CoA + H(+) => a D-alpha-amino acid + acetyl-CoA
RHEA:14767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + excited coelenteramide h monoanion + H(+) + hnu => coelenterazine h + O2
RHEA:10914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate + AMP + diphosphate + H(+) => (R)-pantoate + ATP + beta-alanine
REACT:R-HSA-5610758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)
RHEA:42869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norspermine + S-adenosyl 3-(methylsulfanyl)propylamine => caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine
REACT:R-HSA-1222346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AhpC reduces H2O2 (Homo sapiens)
RHEA:48892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine
RHEA:32152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate => (12E)-9alpha-labda-8(17),12,14-triene + diphosphate
REACT:R-HSA-6791387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the ARID3A gene (Homo sapiens)
REACT:R-SSC-4647593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP400 binds CDKN1A promoter (Sus scrofa)
REACT:R-RNO-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Rattus norvegicus)
RHEA:67737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-neuraminate => aceneuramate
GO:0034897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity
REACT:R-HSA-5654677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR2 (Homo sapiens)
RHEA:72093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + Na(+)(in) => (R)-carnitine(out) + Na(+)(out)
RHEA:63540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin = L-leucine + neurotensin-(1-12)
GO:0016825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid phosphorus-nitrogen bonds
GO:0016825	skos:prefLabel	"Acting on phosphorus-nitrogen bonds"
GO:0016825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on phosphorus-nitrogen bonds"
REACT:R-XTR-9029680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-7 translocates to the nucleus (Xenopus tropicalis)
RHEA:57581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-1-thiol-D-ribulose 5-phosphate
RHEA:50650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)ethylmaleate + H2O => 2-(2-methylsulfanyl)ethylmalate
REACT:R-XTR-177924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)
REACT:R-SSC-1250280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin (Sus scrofa)
RHEA:58592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)
REACT:R-SSC-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Sus scrofa)
RHEA:28669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-propane-1,2-diol + NAD(+) => H(+) + hydroxyacetone + NADH
REACT:R-GGA-159771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein C to protein C (Gallus gallus)
REACT:R-HSA-73931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Homo sapiens)
REACT:R-GGA-265425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with von Willbrand Factor (Gallus gallus)
REACT:R-HSA-9606392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lewis antigens translocate from Golgi lumen to extracellular region (Homo sapiens)
REACT:R-DDI-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Dictyostelium discoideum)
REACT:R-DDI-8944232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XII (Dictyostelium discoideum)
RHEA:65165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + hexan-3-ol => CoA + hexan-3-yl benzoate
RHEA:71195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Zn(2+)(out) = H(+)(in) + Zn(2+)(in)
REACT:R-MMU-8936608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Mus musculus)
EC:3.2.1.91	skos:altLabel	"exocellobiohydrolase"
EC:3.2.1.91	skos:altLabel	"exoglucanase"
EC:3.2.1.91	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellulose 1,4-beta-cellobiosidase (non-reducing end)"
EC:3.2.1.91	skos:altLabel	"1,4-beta-cellobiohydrolase"
EC:3.2.1.91	skos:altLabel	"4-beta-D-glucan cellobiohydrolase (non-reducing end)"
EC:3.2.1.91	skos:altLabel	"exo-1,4-beta-D-glucanase"
EC:3.2.1.91	skos:prefLabel	"cellulose 1,4-beta-cellobiosidase (non-reducing end)"
EC:3.2.1.91	skos:altLabel	"avicelase"
REACT:R-CFA-4086392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Canis familiaris)
REACT:R-DRE-1250280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin (Danio rerio)
RHEA:36238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA
RHEA:25874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyridine N-oxide => H2O2 + pyridine
GO:0102215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + thiocyanate = methyl thiocyanate + S-adenosyl-L-homocysteine
GO:0102215	skos:prefLabel	"thiocyanate methyltransferase"
GO:0102215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiocyanate methyltransferase activity
GO:0102215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiocyanate methyltransferase"
REACT:R-DME-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)
REACT:R-GGA-114392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Gallus gallus)
REACT:R-HSA-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Homo sapiens)
GO:0050410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxododecanoate carboxy-lyase activity
GO:0050410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxolaurate decarboxylase activity
GO:0050410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketolaurate decarboxylase activity
GO:0050410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxododecanoate carboxy-lyase (2-undecanone-forming)
GO:0050410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl decarboxylase activity
REACT:R-HSA-1168642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
REACT:R-DRE-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Danio rerio)
REACT:R-HSA-9694308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3a is externalized together with membrane structures (Homo sapiens)
RHEA:65423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP(in) + NAD(+)(out) <=> GMP(out) + NAD(+)(in)
REACT:R-MMU-8983378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Mus musculus)
RHEA:71275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurolithocholate 3-sulfate(out) = 2 Na(+)(in) + taurolithocholate 3-sulfate(in)
REACT:R-HSA-9661408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Homo sapiens)
RHEA:13190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O => 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)
REACT:R-CFA-1592349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14 (MT1-MMP) binds TIMP2 (Canis familiaris)
RHEA:45576	skos:prefLabel	"ethylmalonyl-CoA mutase"
RHEA:45576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethylmalonyl-CoA mutase"
RHEA:45576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA
RHEA:53074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate
RHEA:12892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + H(+) + NADH
REACT:R-BTA-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Bos taurus)
REACT:R-CEL-3149563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Caenorhabditis elegans)
REACT:R-DRE-9020256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Danio rerio)
RHEA:26090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)
RHEA:25363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) = H(+) + momilactone A + NADH
REACT:R-DDI-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Dictyostelium discoideum)
REACT:R-MMU-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Mus musculus)
REACT:R-HSA-9706720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 E transports Ca2+  (Homo sapiens)
REACT:R-DME-4085133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUM (lumican) binds integrin alpha2beta1 (Drosophila melanogaster)
REACT:R-SCE-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Saccharomyces cerevisiae)
REACT:R-SSC-174105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)
REACT:R-XTR-166726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MASPs (Xenopus tropicalis)
REACT:R-SPO-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)
REACT:R-BTA-5689544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds INO80 complex (Bos taurus)
REACT:R-DME-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Drosophila melanogaster)
REACT:R-MMU-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Mus musculus)
RHEA:48818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2
REACT:R-RNO-9709831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds TBK1 and IRF3 (Rattus norvegicus)
REACT:R-GGA-8941613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)
RHEA:29969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine(out) + H(+)(out) => 2'-deoxyuridine(in) + H(+)(in)
RHEA:44148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine = D-beta-lysine
RHEA:16774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GM1 (d18:1(4E)) + H(+) + UDP
RHEA:47931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + H2O + NADP(+) <=> (2S)-3-sulfolactate + 2 H(+) + NADPH
REACT:R-DRE-5159245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Danio rerio)
RHEA:70896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-cysteinyl-[protein] + O2 => H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]
REACT:R-DRE-1237081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Danio rerio)
RHEA:55104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoheptanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyheptanoyl-[ACP] + NADP(+)
REACT:R-SSC-193981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 oxidises 17HPROG (Sus scrofa)
RHEA:15171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + succinate => H2O + N-succinyl-L-glutamate
RHEA:62752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pravastatin lactone = (S)-2-methylbutanoate + H(+) + pravastatin diol lactone
GO:0102815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity
REACT:R-HSA-216051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1 bind laminin-111 (Homo sapiens)
REACT:R-HSA-5658001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective LCT does not hydrolyze Lac (Homo sapiens)
RHEA:53419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-amino-8-demethylriboflavin + S-adenosyl-L-methionine <=> 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)
REACT:R-BTA-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Bos taurus)
RHEA:69890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + uridine(out) <=> Na(+)(in) + uridine(in)
REACT:R-HSA-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Homo sapiens)
REACT:R-HSA-9662708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB binds IL6 promoter (Homo sapiens)
RHEA:36894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O
GO:0047380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent medium-chain acyl coenzyme A hydrolase activity
GO:0047380	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ADP-dependent myristoyl-CoA thioesterase activity
GO:0047380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent medium-chain acyl-thioester hydrolase activity
GO:0047380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent-medium-chain-acyl-CoA hydrolase activity
GO:0047380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent medium-chain acyl-CoA hydrolase activity
GO:0047380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-dependent medium-chain-acyl-CoA hydrolase activity
GO:0047380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent medium-chain hydrolase activity
RHEA:69905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(in) + 2 Na(+)(in) => cytidine(out) + 2 Na(+)(out)
RHEA:62772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-phenylalanine = N-acetyl-L-phenylalanine
RHEA:19576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + ATP <=> [phosphate](n+1) + ADP
REACT:R-HSA-8848993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated KHDRBS1 translocates to the cytosol (Homo sapiens)
REACT:R-CFA-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Canis familiaris)
REACT:R-XTR-380272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plk1-mediated phosphorylation of Nlp (Xenopus tropicalis)
REACT:R-BTA-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Bos taurus)
REACT:R-SSC-8873850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD5 binds DCA, LCA (Sus scrofa)
RHEA:15544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIMBOA + UDP-alpha-D-glucose <=> DIMBOA beta-D-glucoside + H(+) + UDP
RHEA:58660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine
REACT:R-SSC-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Sus scrofa)
GO:0051871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrofolate binding
GO:0051871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHF binding
GO:0051871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrofolic acid binding
REACT:R-BTA-917744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA loaded synaptic vesicle Docking and Priming (Bos taurus)
REACT:R-HSA-9010539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 gene expression is stimulated by ISL1 (Homo sapiens)
RHEA:14051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene
REACT:R-BTA-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Bos taurus)
RHEA:23385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose => beta-D-glucosyl-(1->4)-D-mannopyranose
RHEA:24140	skos:prefLabel	"23S rRNA (guanosine(2251)-2'-O)-methyltransferase"
RHEA:24140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (guanosine(2251)-2'-O)-methyltransferase"
RHEA:24140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:17207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate
REACT:R-BTA-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Bos taurus)
REACT:R-HSA-442273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)
REACT:R-HSA-380200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)
REACT:R-BTA-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Bos taurus)
RHEA:20034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopenicillin N => penicillin N
REACT:R-CFA-2454081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5 oxidises 11cROL to 11cRAL (Canis familiaris)
RHEA:28454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-fructosyl)-L-lysine(in) = N(6)-(D-fructosyl)-L-lysine(out)
RHEA:72223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) = 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)
RHEA:11058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminophenol + CO2 + H2O + NADP(+) => 4-aminobenzoate + 2 H(+) + NADPH + O2
REACT:R-MMU-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Mus musculus)
REACT:R-DRE-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Danio rerio)
REACT:R-SSC-162836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Sus scrofa)
RHEA:65990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol => previtamin D3
RHEA:59762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-beta-D-glucoside + H(+) + UDP => apigenin + UDP-alpha-D-glucose
RHEA:28987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-acetylneuraminate(out)
RHEA:23817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + putrescine => 4-aminobutanal + L-glutamate
REACT:R-GGA-5654565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Gallus gallus)
RHEA:39299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)
REACT:R-XTR-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Xenopus tropicalis)
REACT:R-CEL-5617179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates TNNI3 (Caenorhabditis elegans)
REACT:R-CFA-977301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histidine is decarboxylated to histamine (Canis familiaris)
REACT:R-CEL-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Caenorhabditis elegans)
RHEA:44777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-6 + S-adenosyl-L-methionine => H(+) + menaquinol-6 + S-adenosyl-L-homocysteine
REACT:R-GGA-373074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR9  binds CCL25 ligand (Gallus gallus)
RHEA:15289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,4-beta-D-xylan synthase"
RHEA:15289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose = [(1->4)-beta-D-xylan](n+1) + H(+) + UDP
RHEA:15289	skos:prefLabel	"1,4-beta-D-xylan synthase"
REACT:R-RNO-390329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of AKT by PP2A (Rattus norvegicus)
RHEA:71703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurocholate(out) = taurocholate(in)
REACT:R-HSA-9705010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 nsp6 binds TBK1 (Homo sapiens)
REACT:R-BTA-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Bos taurus)
REACT:R-SPO-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Schizosaccharomyces pombe)
RHEA:53095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine
GO:0008110	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histidine transaminase activity
GO:0008110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine:2-oxoglutarate aminotransferase activity
GO:0008110	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histidine aminotransferase activity
GO:0008110	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine-2-oxoglutarate aminotransferase activity
REACT:R-SSC-5251942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hikeshi binds HSP70s:ATP (Sus scrofa)
REACT:R-HSA-9682009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCRB1 binds 5'UTR of SARS-CoV-1 genomic RNA (Homo sapiens)
REACT:R-GGA-8987230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Gallus gallus)
GO:0018670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate 1-monooxygenase activity
GO:0018670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
GO:0018670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobenzoate dehydrogenase activity
GO:0018670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate hydroxylase activity
GO:0018670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobenzoate monooxygenase activity
REACT:R-CFA-8938829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Canis familiaris)
REACT:R-DME-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Drosophila melanogaster)
REACT:R-RNO-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Rattus norvegicus)
REACT:R-DRE-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Danio rerio)
REACT:R-SSC-8869667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxLDL:CD36 binds TLR4:TLR6 (Sus scrofa)
REACT:R-SSC-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Sus scrofa)
RHEA:49923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)
RHEA:29760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanoate(in) => octanoate(out)
EC:3.4.24.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neprilysin"
EC:3.4.24.11	skos:altLabel	"neutral endopeptidase"
EC:3.4.24.11	skos:altLabel	"endopeptidase-2"
EC:3.4.24.11	skos:altLabel	"kidney-brush-border neutral proteinase"
EC:3.4.24.11	skos:altLabel	"enkephalinase"
EC:3.4.24.11	skos:prefLabel	"neprilysin"
EC:3.4.24.11	skos:altLabel	"membrane metalloendopeptidase"
RHEA:28758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + sn-glycerol 3-phosphate <=> a ubiquinol + dihydroxyacetone phosphate
REACT:R-BTA-1067651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)
RHEA:55462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-1222407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide and nitric oxide react to peroxynitrite (Homo sapiens)
REACT:R-SPO-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Schizosaccharomyces pombe)
REACT:R-CEL-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Caenorhabditis elegans)
GO:0033455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCA codon-amino acid adaptor activity
GO:0033455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine tRNA
REACT:R-CEL-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Caenorhabditis elegans)
REACT:R-HSA-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Homo sapiens)
REACT:R-MMU-9011985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Mus musculus)
RHEA:53637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine
RHEA:65020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-ornithine
RHEA:33337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctadecanoyl-sn-glycerol + phosphate => 1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O
REACT:R-BTA-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Bos taurus)
REACT:R-DRE-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Danio rerio)
REACT:R-GGA-2089971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of collagens (Gallus gallus)
RHEA:67926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP => 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate
RHEA:60441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl acetate => acetate + H(+) + methanol
REACT:R-XTR-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Xenopus tropicalis)
GO:0050238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxin 5-dehydrogenase activity
GO:0050238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxol 5-dehydrogenase activity
GO:0050238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxine:(acceptor) 5-oxidoreductase activity
GO:0050238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal-5-dehydrogenase activity
GO:0050238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxine:acceptor 5-oxidoreductase activity
GO:0050238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine 5-dehydrogenase activity
GO:0050238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxine 5'-dehydrogenase activity
RHEA:41181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-SCE-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Saccharomyces cerevisiae)
REACT:R-CFA-4720432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Canis familiaris)
REACT:R-PFA-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Plasmodium falciparum)
REACT:R-XTR-4570489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO2 (Xenopus tropicalis)
RHEA:67354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-malonyl-rhaponticin + CoA => malonyl-CoA + rhaponticin
RHEA:21604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	styrene oxide = 2-phenylacetaldehyde
RHEA:21604	skos:prefLabel	"styrene-oxide isomerase"
RHEA:21604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"styrene-oxide isomerase"
RHEA:21604	skos:altLabel	"SOI"
REACT:R-RNO-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Rattus norvegicus)
RHEA:33747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)
RHEA:52122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-5692283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Sus scrofa)
REACT:R-HSA-6798304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the E2F7 gene (Homo sapiens)
REACT:R-BTA-76456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-atom dealkylation of dextromethorphan (Bos taurus)
RHEA:29503	skos:prefLabel	"patchoulol synthase"
RHEA:29503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"patchoulol synthase"
RHEA:29503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = diphosphate + patchoulol
RHEA:71819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-thyroxine(out) = L-thyroxine(in)
REACT:R-HSA-913424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
REACT:R-MMU-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Mus musculus)
REACT:R-XTR-1676164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Xenopus tropicalis)
REACT:R-HSA-917807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Homo sapiens)
RHEA:66403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycocholate(in) + H2O <=> ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate
RHEA:41374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
RHEA:16716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-succinylglutathione <=> glutathione + H(+) + succinate
REACT:R-MMU-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Mus musculus)
RHEA:16769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)
RHEA:16769	skos:prefLabel	"glucose-1,6-bisphosphate synthase"
RHEA:16769	skos:altLabel	"glucose-1,6-bisphosphate synthetase"
RHEA:16769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)
RHEA:16769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-1,6-bisphosphate synthase"
RHEA:16769	skos:altLabel	"glucose 1,6-diphosphate synthase"
REACT:R-BTA-110355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MUTYH glycosylase by APEX1 at the AP site (Bos taurus)
REACT:R-HSA-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Homo sapiens)
REACT:R-HSA-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Homo sapiens)
RHEA:53328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2,3-diacyl-alpha-D-glucosamine = 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP
RHEA:63485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]
REACT:R-CFA-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Canis familiaris)
GO:0097429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid ligation activity by nonribosomal peptide synthase
RHEA:53549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin J2 => Delta(12)-prostaglandin J2
REACT:R-DME-5669240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLNA binds PAK1 (Drosophila melanogaster)
REACT:R-SSC-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Sus scrofa)
REACT:R-XTR-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Xenopus tropicalis)
REACT:R-SCE-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Saccharomyces cerevisiae)
RHEA:15123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite => dithioerythritol + thiosulfate
REACT:R-RNO-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)
REACT:R-BTA-9667914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand midkine (MDK) (Bos taurus)
RHEA:61844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solasodine + UDP-alpha-D-glucose = H(+) + solasodine 3-beta-D-glucoside + UDP
RHEA:47387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetoxyphenol + H2O <=> acetate + H(+) + hydroquinone
REACT:R-BTA-5660663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 cleaves IL1B precursor (Bos taurus)
RHEA:22327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene A4 <=> leukotriene B4
RHEA:47803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-methionine
GO:0030332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin binding
REACT:R-BTA-1247497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds neuregulins (Bos taurus)
REACT:R-HSA-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Homo sapiens)
RHEA:23250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine
REACT:R-GGA-8863494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASICs bind STOML3, (STOM) (Gallus gallus)
RHEA:17938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate => methylglyoxal + phosphate
REACT:R-HSA-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Homo sapiens)
REACT:R-BTA-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Bos taurus)
REACT:R-HSA-159431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Homo sapiens)
REACT:R-DRE-164834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enzyme-bound ATP is released (Danio rerio)
RHEA:24896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopimpinellin + S-adenosyl-L-homocysteine => 5-hydroxyxanthotoxin + S-adenosyl-L-methionine
REACT:R-GGA-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Gallus gallus)
RHEA:40123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-9661425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB dissociates (Sus scrofa)
GO:0051908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0051908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity
REACT:R-BTA-177107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion and activation of the latent large complex of TGF-beta-1 (Bos taurus)
REACT:R-DRE-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Danio rerio)
RHEA:72003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(in) + urate(out) = (S)-lactate(out) + urate(in)
REACT:R-HSA-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)
RHEA:27772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine
REACT:R-DRE-1299297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of THIK (Danio rerio)
REACT:R-HSA-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Homo sapiens)
RHEA:48483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP
REACT:R-HSA-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
REACT:R-BTA-508513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B binds JAK3 (Bos taurus)
RHEA:14407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone + H(+) + NADPH => D-glucose + NADP(+)
RHEA:52587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH
GO:0000832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity
GO:0000832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol hexakisphosphate 5-kinase activity
RHEA:25624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate <=> tuberculosinyl diphosphate
RHEA:48871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADH <=> AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide
REACT:R-SPO-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Schizosaccharomyces pombe)
RHEA:71402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxusin <=> 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Danio rerio)
RHEA:31818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-(E)-beta-caryophyllene + diphosphate
RHEA:11100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyhexan-3-one = 2 propanal
RHEA:11100	skos:altLabel	"4-hydroxy-3-hexanone aldolase"
RHEA:11100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"propioin synthase"
RHEA:11100	skos:prefLabel	"propioin synthase"
RHEA:11100	skos:altLabel	"4-hydroxy-3-hexanone propanal-lyase"
RHEA:67501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine
REACT:R-DME-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Drosophila melanogaster)
RHEA:61584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-163120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Telomerase RNP and the Chromosome End (Rattus norvegicus)
REACT:R-HSA-6789109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide anion reacts with Fe-S cluster (Homo sapiens)
REACT:R-HSA-9618811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium binds calmodulin at the synapse (Homo sapiens)
RHEA:67127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxide + L-cysteinyl-[protein] <=> an alcohol + S-hydroxy-L-cysteinyl-[protein]
RHEA:51148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + 2 oxidized [azurin] = an aldehyde + 2 H(+) + 2 reduced [azurin]
RHEA:51148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol dehydrogenase (azurin)"
RHEA:51148	skos:prefLabel	"alcohol dehydrogenase (azurin)"
RHEA:51148	skos:altLabel	"QHEDH"
REACT:R-HSA-3772430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNBIP1 binds beta-catenin (Homo sapiens)
REACT:R-HSA-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Homo sapiens)
REACT:R-HSA-5661124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR4-HIST1H4 (Homo sapiens)
REACT:R-XTR-202168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ZAP-70 by Lck (Xenopus tropicalis)
REACT:R-DRE-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Danio rerio)
GO:0004878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C5a receptor activity
GO:0004878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C5a anaphylatoxin receptor activity
RHEA:57921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) => H(+) + L-asparaginyl-tRNA(Asn) + phosphate
RHEA:38287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalate + succinyl-CoA = (3S)-citramalyl-CoA + succinate
REACT:R-MMU-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Mus musculus)
REACT:R-DME-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Drosophila melanogaster)
REACT:R-XTR-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Xenopus tropicalis)
RHEA:45114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxy-gamma-tocopherol + H2O + NADP(+) => gamma-tocopherol + H(+) + NADPH + O2
RHEA:62888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + lactose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)
REACT:R-CFA-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Canis familiaris)
REACT:R-XTR-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Xenopus tropicalis)
REACT:R-MMU-6792863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PP2R5C dephosphorylates MDM2 (Mus musculus)
RHEA:55064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanoyl-CoA + H2O = 4-methylpentanoate + CoA + H(+)
REACT:R-BTA-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Bos taurus)
REACT:R-DME-1358792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates activated ERBB3 (Drosophila melanogaster)
REACT:R-DME-3928627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB phosphorylates TIAM1 (Drosophila melanogaster)
RHEA:46623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
REACT:R-XTR-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Xenopus tropicalis)
RHEA:16692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + H2O <=> D-glucose + phosphate
REACT:R-RNO-936951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to activated TLR4 complex (Rattus norvegicus)
REACT:R-CFA-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Canis familiaris)
RHEA:47492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isodeoxycholate + NAD(+)
REACT:R-CFA-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Canis familiaris)
RHEA:38818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine
REACT:R-RNO-5684875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR:ATRIP to RPA at resected DNA DSBs (Rattus norvegicus)
REACT:R-DRE-391378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follicle-stimulating hormone receptor can bind FSH (Danio rerio)
REACT:R-RNO-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Rattus norvegicus)
REACT:R-DRE-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Danio rerio)
REACT:R-BTA-1370500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR binds SCF beta-TrCP complex (Bos taurus)
REACT:R-CFA-8944225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVII (Canis familiaris)
REACT:R-DRE-159733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor X to factor X (Danio rerio)
GO:0102566	skos:altLabel	"palmitoyldihydroxyacetone-phosphate reductase"
GO:0102566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl dihydroxyacetone phosphate reductase activity
GO:0102566	skos:prefLabel	"acylglycerone-phosphate reductase"
GO:0102566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acylglycerone-phosphate reductase"
REACT:R-RNO-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Rattus norvegicus)
REACT:R-HSA-1564112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VI degradation by MMP2,9,11 (Homo sapiens)
RHEA:68422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-iso(homo)3citrate => cis-(homo)3aconitate + H2O
REACT:R-CFA-8987270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Canis familiaris)
RHEA:50148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid ethyl ester + H2O = a fatty acid + ethanol + H(+)
RHEA:19030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + H2O + urea-1-carboxylate => 2 CO2 + 2 NH4(+)
EC:4.7.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carbon-phosphorus lyases"
EC:4.7.-.-	skos:prefLabel	"Carbon-phosphorus lyases"
REACT:R-SSC-5654428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates SHC1 (Sus scrofa)
REACT:R-DME-2161620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by PTGDS (Drosophila melanogaster)
RHEA:12295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine + tRNA(Ser) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)
REACT:R-BTA-430158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds VAV (Bos taurus)
REACT:R-DRE-2990842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO2 (Danio rerio)
REACT:R-MMU-8944225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVII (Mus musculus)
RHEA:72515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + glutarate(in) = (R)-carnitine(in) + glutarate(out)
RHEA:69524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + O2 = D-glucose + H2O2
RHEA:23481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylene-3-methylsuccinate => dimethylmaleate
REACT:R-MMU-420592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectin-like (Necl) proteins (Mus musculus)
RHEA:41832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+)
REACT:R-CEL-4641260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)
REACT:R-XTR-8857555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates GPNMB (Xenopus tropicalis)
RHEA:36417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine
REACT:R-HSA-5635864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH ubiquitinates GLI1 (Homo sapiens)
RHEA:43165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-deazaguanine + guanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + guanine
GO:0033912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-2,6-fructan-6-levanbiohydrolase activity
GO:0033912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-beta-D-fructan 6-levanbiohydrolase activity
GO:0033912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity
GO:0033912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-beta-fructan 6-levanbiohydrolase activity
GO:0033912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity
GO:0033912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	levanbiose-producing levanase activity
REACT:R-XTR-5635861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH binds GLI1 (Xenopus tropicalis)
RHEA:34456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene => 9-cis-beta-carotene
REACT:R-GGA-5687758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP4C:PPP4R2 dephosphorylates RPA2 (Gallus gallus)
REACT:R-CFA-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Canis familiaris)
REACT:R-DRE-8848215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Danio rerio)
RHEA:70869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) + L-glutamine(out) + Na(+)(in) => L-alanine(out) + L-glutamine(in) + Na(+)(out)
RHEA:15503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + L-glutamine + NADPH => 2 L-glutamate + NADP(+)
RHEA:47092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-dihydrodipicolinate + NADP(+) = dipicolinate + H(+) + NADPH
RHEA:31080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisovaleryl-CoA => 3-methyl-(2E)-butenoyl-CoA + H2O
RHEA:72230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + sarcosine(out) <=> chloride(in) + 2 Na(+)(in) + sarcosine(in)
RHEA:69586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + IMP => GMP + inosine
REACT:R-DRE-8948226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Danio rerio)
REACT:R-CFA-205231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of KIT upon SCF binding (Canis familiaris)
RHEA:50837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate
REACT:R-CFA-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Canis familiaris)
REACT:R-MMU-374673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds RanBPM (Mus musculus)
REACT:R-RNO-193491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Rattus norvegicus)
REACT:R-MMU-8849857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates CELA2 (Mus musculus)
REACT:R-DRE-9654533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B recycles to the plasma membrane (Danio rerio)
REACT:R-BTA-8849638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the SPINK5:KLK5 complex at low pH (Bos taurus)
RHEA:63504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daunorubicin + H(+) + NADPH = 13-dihydrodaunorubicin + NADP(+)
REACT:R-MMU-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Mus musculus)
REACT:R-XTR-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Xenopus tropicalis)
REACT:R-HSA-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)
REACT:R-MMU-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
RHEA:51628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) + UTP = CO2 + dUTP + H2O
RHEA:32266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + pyruvate <=> L-alanine + succinate semialdehyde
RHEA:54594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+)
REACT:R-MMU-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)
REACT:R-BTA-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Bos taurus)
REACT:R-DRE-158941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Danio rerio)
RHEA:56686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine => dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Bos taurus)
REACT:R-DRE-114354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP:Caspase-7 (Danio rerio)
REACT:R-GGA-421439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3 (Gallus gallus)
REACT:R-RNO-448744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20RA binds IL20RB (Rattus norvegicus)
RHEA:22673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate => diphosphate + presqualene diphosphate
RHEA:27407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + acetate + CO2 => a ubiquinone + H2O + pyruvate
REACT:R-XTR-192065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)
REACT:R-HSA-174121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Securin with Cdc20:APC/C complex (Homo sapiens)
REACT:R-CEL-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Caenorhabditis elegans)
GO:0001607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMUR activity
GO:0001607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuromedin U receptor activity
REACT:R-CEL-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)
REACT:R-BTA-4084903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types VI, IX bind integrin alpha10beta1 (Bos taurus)
REACT:R-MMU-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Mus musculus)
REACT:R-MMU-6804402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F1 (Mus musculus)
GO:0018547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NG reductase activity
GO:0018547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitroglycerin reductase activity
REACT:R-GGA-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Gallus gallus)
REACT:R-RNO-8935732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds SIN3A,(SIN3B) co-repressor (Rattus norvegicus)
REACT:R-DDI-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Dictyostelium discoideum)
REACT:R-XTR-432897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ILK interacts with beta-1 integrin (Xenopus tropicalis)
RHEA:28885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-threonine(out) => H(+)(in) + L-threonine(in)
RHEA:60967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP
REACT:R-SCE-2172678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)
REACT:R-HSA-450984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Homo sapiens)
RHEA:58362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2
RHEA:19143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol => all-trans-retinol
EC:2.4.1.86	skos:prefLabel	"N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase"
EC:2.4.1.86	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase"
EC:2.4.1.86	skos:altLabel	"paragloboside synthase"
EC:2.4.1.86	skos:altLabel	"lactotriaosylceramide 4-beta-galactosyltransferase"
EC:2.4.1.86	skos:altLabel	"glucosaminylgalactosylglucosylceramide beta-galactosyltransferase"
EC:2.4.1.86	skos:altLabel	"glucosaminylgalactosylglucosylceramide 4-beta-galactosyltransferase"
REACT:R-RNO-5682588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 binds phosphorylated MDC1 at DNA DSBs (Rattus norvegicus)
RHEA:63297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine
RHEA:53172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)
RHEA:26481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) <=> a 2-demethylmenaquinol + CO2 + diphosphate
RHEA:21476	skos:altLabel	"1,3-beta-D-glucan-UDP glucosyltransferase"
RHEA:21476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,3-beta-glucan synthase"
RHEA:21476	skos:altLabel	"1,3-beta-D-glucan--UDP glucosyltransferase"
RHEA:21476	skos:altLabel	"UDP-glucose-1,3-beta-D-glucan glucosyltransferase"
RHEA:21476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP
RHEA:21476	skos:prefLabel	"1,3-beta-glucan synthase"
RHEA:21476	skos:altLabel	"callose synthetase"
RHEA:21476	skos:altLabel	"UDP-glucose--3-beta-D-glucan glucosyltransferase"
RHEA:21476	skos:altLabel	"callose synthase"
RHEA:63216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-carbaguanosine(15) in tRNA + L-lysine = 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA
REACT:R-HSA-4720478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALG9 does not add the seventh mannose to the N-glycan precursor (Homo sapiens)
RHEA:50399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA <=> 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O
GO:0070061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose binding
RHEA:66244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + IC-asc-C9 = diphosphate + IC-asc-C9-AMP
REACT:R-SCE-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)
RHEA:46777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SPO-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Schizosaccharomyces pombe)
REACT:R-SCE-194642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Saccharomyces cerevisiae)
REACT:R-BTA-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Bos taurus)
REACT:R-MMU-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Mus musculus)
RHEA:43957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate
REACT:R-MMU-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Mus musculus)
REACT:R-BTA-216050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Bos taurus)
REACT:R-HSA-976734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Amyloid fibrils have additional components (Homo sapiens)
REACT:R-BTA-1483002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to 1-acyl GO3P by GNPAT (Bos taurus)
REACT:R-DRE-9735946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET small tyrosine kinase inhibitors bind MET (Danio rerio)
RHEA:11650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-menthane-3,8-diol + H2O + NADP(+) => (-)-menthol + H(+) + NADPH + O2
RHEA:67708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate
REACT:R-BTA-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)
GO:0050406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[acetyl-CoA carboxylase]-phosphatase activity
GO:0050406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA carboxylase-phosphatase activity
GO:0050406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity
REACT:R-DDI-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Dictyostelium discoideum)
RHEA:49902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + phenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate + O2
RHEA:21399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) <=> CO2 + Na(+)(out) + propanoyl-CoA
REACT:R-RNO-420592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectin-like (Necl) proteins (Rattus norvegicus)
REACT:R-DRE-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Danio rerio)
RHEA:10238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP => trans-2-coumarate + UDP-alpha-D-glucose
EC:5.5.1.6	skos:prefLabel	"chalcone isomerase"
EC:5.5.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chalcone isomerase"
EC:5.5.1.6	skos:altLabel	"chalcone--flavanone isomerase"
REACT:R-HSA-9731924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds EDNs (Homo sapiens)
REACT:R-XTR-9603984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Xenopus tropicalis)
RHEA:24506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2
RHEA:19774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sn-glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + H(+) + NADPH
RHEA:38400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)
RHEA:48307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
REACT:R-SCE-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Saccharomyces cerevisiae)
RHEA:39276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH => (15Z)-tetracosenoyl-CoA + NADP(+)
REACT:R-DDI-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Dictyostelium discoideum)
REACT:R-CEL-8865454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX3 (Caenorhabditis elegans)
REACT:R-XTR-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Xenopus tropicalis)
RHEA:19169	skos:altLabel	"L-serine deaminase"
RHEA:19169	skos:altLabel	"L-hydroxyaminoacid dehydratase"
RHEA:19169	skos:altLabel	"serine deaminase"
RHEA:19169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-serine ammonia-lyase"
RHEA:19169	skos:altLabel	"L-serine hydro-lyase (deaminating)"
RHEA:19169	skos:prefLabel	"L-serine ammonia-lyase"
RHEA:19169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine = NH4(+) + pyruvate
RHEA:19169	skos:altLabel	"L-serine dehydratase"
EC:3.4.21.47	skos:altLabel	"C5 convertase"
EC:3.4.21.47	skos:altLabel	"complement component C3/C5 convertase (alternative)"
EC:3.4.21.47	skos:altLabel	"C3 proactivator"
EC:3.4.21.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alternative-complement-pathway C3/C5 convertase"
EC:3.4.21.47	skos:altLabel	"C3 convertase"
EC:3.4.21.47	skos:prefLabel	"alternative-complement-pathway C3/C5 convertase"
EC:3.4.21.47	skos:altLabel	"properdin factor B"
EC:3.4.21.47	skos:altLabel	"complement factor B"
RHEA:15103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-lysine => H(+) + meso-2,6-diaminoheptanedioate
REACT:R-DDI-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Dictyostelium discoideum)
RHEA:28910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) <=> 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)
REACT:R-DRE-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Danio rerio)
REACT:R-CFA-6784861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG binds LPL dimer (Canis familiaris)
RHEA:19543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-glutamyl 5-phosphate + NADPH => L-glutamate 5-semialdehyde + NADP(+) + phosphate
GO:0031896	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	V2 vasopressin receptor ligand
GO:0031896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	V2 vasopressin receptor binding
REACT:R-BTA-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Bos taurus)
REACT:R-DDI-2160492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4I1:FAD oxidises L-Phe to kPPV (Dictyostelium discoideum)
REACT:R-BTA-8936608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Bos taurus)
REACT:R-BTA-5626988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds NSMAF (Bos taurus)
REACT:R-HSA-5617479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA2 mRNA is translated (Homo sapiens)
RHEA:25598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate
REACT:R-CFA-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Canis familiaris)
RHEA:52182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-8948015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Danio rerio)
REACT:R-BTA-416358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) inhibits PI3K alpha (Bos taurus)
RHEA:56689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 => (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate
REACT:R-BTA-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Bos taurus)
EC:2.4.1.315	skos:altLabel	"MGlcDAG (1->6) glucosyltransferase"
EC:2.4.1.315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diglucosyl diacylglycerol synthase (1,6-linking)"
EC:2.4.1.315	skos:altLabel	"DGlcDAG synthase"
EC:2.4.1.315	skos:prefLabel	"diglucosyl diacylglycerol synthase (1,6-linking)"
EC:2.4.1.315	skos:altLabel	"monoglucosyl diacylglycerol (1->6) glucosyltransferase"
RHEA:18067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + phosphonate(in) => ATP + H2O + phosphonate(out)
REACT:R-SSC-933531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-IRF7:p-IRF7 to nucleus (Sus scrofa)
REACT:R-CFA-5654637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
GO:0009940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino-terminal vacuolar sorting propeptide binding
REACT:R-SCE-198563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO1 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)
REACT:R-BTA-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
REACT:R-HSA-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Homo sapiens)
REACT:R-CFA-8853252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2:C3d,C3dg,iC3b binds CD19:CD81 (Canis familiaris)
REACT:R-BTA-210282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GPVI and FceRI gamma (Bos taurus)
RHEA:53030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate
REACT:R-GGA-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Gallus gallus)
REACT:R-MMU-5617815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binds RAB3IP (Mus musculus)
REACT:R-RNO-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Rattus norvegicus)
REACT:R-BTA-6785361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of FANCD2:FANCI (Bos taurus)
REACT:R-SSC-2201293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TLR4:LY96:LPS:CD14 (Sus scrofa)
REACT:R-BTA-201810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ligand trap binds the ligand BMP2, blocking BMP signalling (Bos taurus)
REACT:R-CFA-2066781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Canis familiaris)
REACT:R-CFA-5340214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB binds O2 (Canis familiaris)
REACT:R-DRE-879377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Danio rerio)
REACT:R-DRE-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Danio rerio)
RHEA:68882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + NADP(+) + salicylaldehyde => ATP + H(+) + NADPH + salicylate
RHEA:25278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP + H2O => AMP + H(+)
RHEA:59496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:38289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA + succinate => (3S)-citramalate + succinyl-CoA
REACT:R-DRE-76054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Danio rerio)
REACT:R-DME-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Drosophila melanogaster)
RHEA:32010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene
REACT:R-MMU-8955289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
REACT:R-GGA-5694487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A4GNT transfers GlcNAc to core 2 mucins (Gallus gallus)
REACT:R-CFA-8954110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1:EPC1 binds the PRC2 complex (Canis familiaris)
RHEA:66304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide
RHEA:22553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + an alcohol => adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)
REACT:R-SCE-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Saccharomyces cerevisiae)
RHEA:21224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingosine cholinephosphotransferase"
RHEA:21224	skos:prefLabel	"sphingosine cholinephosphotransferase"
RHEA:21224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-choline + sphing-4-enine = CMP + H(+) + sphing-4-enine-phosphocholine
RHEA:33980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIBOA beta-D-glucoside + H2O => D-glucose + DIBOA
REACT:R-BTA-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Bos taurus)
RHEA:53722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate => ATP + N-acetyl-D-muramate
RHEA:28691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + a ubiquinone = a ubiquinol + orotate
REACT:R-GGA-2467809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)
RHEA:71307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-valine(out) + 2 Na(+)(out) = chloride(in) + L-valine(in) + 2 Na(+)(in)
RHEA:15707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinol + phenylglyoxylyl-CoA => 2 a ubiquinone + H2O + phenylacetyl-CoA
RHEA:28250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + malonyl-CoA = acetoacetyl-CoA + CO2 + CoA
RHEA:28250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetoacetyl-CoA synthase"
RHEA:28250	skos:altLabel	"NphT7"
RHEA:28250	skos:prefLabel	"acetoacetyl-CoA synthase"
REACT:R-DRE-1605591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Danio rerio)
REACT:R-SSC-5607744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 binds BCL10 (Sus scrofa)
REACT:R-HSA-5433066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C (Homo sapiens)
REACT:R-MMU-1793182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Mus musculus)
REACT:R-HSA-5638141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)
REACT:R-GGA-9707690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 binds MAFK (Gallus gallus)
REACT:R-CFA-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Canis familiaris)
RHEA:68543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate
REACT:R-RNO-1471322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins are secreted (Rattus norvegicus)
REACT:R-HSA-3244614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGAS produces cyclic GMP-AMP (Homo sapiens)
RHEA:64525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA => 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]
RHEA:55036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N,N-dimethylornithine lipid + S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine
GO:0050551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myrcene synthase activity
GO:0050551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity
REACT:R-CFA-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)
REACT:R-BTA-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Bos taurus)
REACT:R-HSA-4090390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates AR with SUMO1 (Homo sapiens)
RHEA:62062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose
REACT:R-HSA-416929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PGF2a (Homo sapiens)
REACT:R-HSA-8987014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Homo sapiens)
REACT:R-CFA-5685649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPAs translocate from ER membrane to extracellular region (Canis familiaris)
GO:0019834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase A2 inhibitor activity
RHEA:18258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen III + 2 H(+) + O2 => 2 CO2 + 2 H2O + protoporphyrinogen IX
REACT:R-CEL-6788912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)
RHEA:62550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose
RHEA:24898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diguanylate cyclase"
RHEA:24898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 GTP = 3',3'-c-di-GMP + 2 diphosphate
RHEA:24898	skos:prefLabel	"diguanylate cyclase"
RHEA:24898	skos:altLabel	"DGC"
REACT:R-BTA-1112690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds CBL (Bos taurus)
REACT:R-DRE-5357776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Danio rerio)
REACT:R-DDI-9014293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GDIs block activation of RAC2 (Dictyostelium discoideum)
REACT:R-MMU-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Mus musculus)
RHEA:39966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate
REACT:R-BTA-2002401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Bos taurus)
RHEA:63106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxy-ilicicolin A epoxide + H2O + NADP(+) => H(+) + ilicicolin A epoxide + NADPH + O2
REACT:R-DRE-74712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of IRS-P from insulin receptor (Danio rerio)
REACT:R-DME-8954082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds the PRC1 complex (Drosophila melanogaster)
REACT:R-RNO-4570463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Rattus norvegicus)
REACT:R-CEL-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Caenorhabditis elegans)
REACT:R-HSA-5666104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Homo sapiens)
RHEA:60610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-CEL-200410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Caenorhabditis elegans)
RHEA:44410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-HSA-73736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SL1 (Homo sapiens)
REACT:R-DME-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Drosophila melanogaster)
GO:0102394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-isoleucine dehydrogenase activity
RHEA:56159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:30702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + beta-alanine <=> 3-oxopropanoate + L-glutamate
REACT:R-CFA-354149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
REACT:R-HSA-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Homo sapiens)
REACT:R-GGA-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Gallus gallus)
REACT:R-SCE-2066788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Saccharomyces cerevisiae)
REACT:R-SSC-9646685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggresome dissociates from dynein and microtubule (Sus scrofa)
REACT:R-HSA-9035954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP17A1 does not 17-hydroxylate P4 (Homo sapiens)
RHEA:39909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose
REACT:R-DRE-6788611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYKK phosphorylates 5HLYS (Danio rerio)
REACT:R-SPO-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Schizosaccharomyces pombe)
RHEA:14400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (4Z)-2-oxohept-4-enedioate + CO2
RHEA:39571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Drosophila melanogaster)
REACT:R-DDI-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Dictyostelium discoideum)
REACT:R-DME-9021609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR-associated SRC autophosphorylates (Drosophila melanogaster)
RHEA:17651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + malonyl-[ACP] => acetyl-[ACP] + malonate
REACT:R-RNO-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Rattus norvegicus)
RHEA:58446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine
REACT:R-GGA-8864343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD1 binds TFAP2 homo- and heterodimers (Gallus gallus)
REACT:R-RNO-983266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins bind microtubules (Rattus norvegicus)
GO:0051373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calsarcin 2 binding
GO:0051373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle
GO:0051373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FATZ binding
GO:0051373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FATZ 2 binding
GO:0051373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calsarcin 1 binding
GO:0051373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FATZ 3 binding
GO:0051373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calsarcin binding
GO:0051373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FATZ 1 binding
GO:0051373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calsarcin 3 binding
REACT:R-HSA-1592349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14 (MT1-MMP) binds TIMP2 (Homo sapiens)
REACT:R-SCE-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Saccharomyces cerevisiae)
REACT:R-DDI-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Dictyostelium discoideum)
GO:0015158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	raffinose permease
GO:0015158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raffinose transmembrane transporter activity
RHEA:40972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:51289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
REACT:R-GGA-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Gallus gallus)
REACT:R-BTA-6781899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds SIAH2 (Bos taurus)
REACT:R-DME-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Drosophila melanogaster)
REACT:R-BTA-156808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Bos taurus)
RHEA:61573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoate + O2 => (15S)-hydroperoxy-(11Z,13E)-eicosadienoate
REACT:R-HSA-74711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRS (Homo sapiens)
REACT:R-CEL-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
RHEA:61385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate
RHEA:13459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+)
REACT:R-DME-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)
REACT:R-XTR-4551727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Xenopus tropicalis)
RHEA:47314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-6791227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Sus scrofa)
REACT:R-HSA-182594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of INK4 family proteins with CDK4/6 (Homo sapiens)
REACT:R-CFA-5159245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Canis familiaris)
REACT:R-SSC-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Sus scrofa)
REACT:R-MMU-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Mus musculus)
RHEA:26065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hygromycin B => 4-O-phosphohygromycin B + ADP + H(+)
REACT:R-HSA-9029150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Homo sapiens)
REACT:R-MMU-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Mus musculus)
REACT:R-SSC-9708430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 (CRM1) binds to BACH1:Hemes (Sus scrofa)
GO:0034880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrazinate dehydrogenase activity
REACT:R-GGA-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Gallus gallus)
EC:1.3.1.87	skos:altLabel	"2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase"
EC:1.3.1.87	skos:prefLabel	"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase"
EC:1.3.1.87	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase"
EC:1.3.1.87	skos:altLabel	"cis-dihydrodiol dehydrogenase"
RHEA:69656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + quercetin 3-O-beta-D-glucoside => beta-D-glucose + quercetin
REACT:R-BTA-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Bos taurus)
RHEA:70143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) = all-trans-4,4'-diaponeurosporene + FADH2
REACT:R-DME-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Drosophila melanogaster)
RHEA:53782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-muricholoyl-CoA + lithocholate => beta-muricholate + lithocholoyl-CoA
RHEA:20811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-7-O-acetylneuraminate
GO:0047190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acylglycerophosphocholine O-acyltransferase activity
GO:0047190	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-acylglycerophosphocholine acyltransferase activity
GO:0047190	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-acylglycerol-3-phosphorylcholine acyltransferase activity
GO:0047190	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity
REACT:R-XTR-450422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP recruits RNA degradation activities (Xenopus tropicalis)
REACT:R-DDI-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)
REACT:R-DRE-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Danio rerio)
REACT:R-MMU-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Mus musculus)
REACT:R-SSC-9647643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds bacterial cardiolipin (Sus scrofa)
REACT:R-CEL-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Caenorhabditis elegans)
GO:0052847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
REACT:R-MMU-1234173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)
RHEA:66516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:30307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-methylxanthine demethylase"
RHEA:30307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine
RHEA:30307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine
RHEA:30307	skos:prefLabel	"7-methylxanthine demethylase"
REACT:R-HSA-9606622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)
RHEA:70242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside
REACT:R-RNO-6782224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)
RHEA:53319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
REACT:R-CFA-2187309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer binds SP1 (Canis familiaris)
REACT:R-XTR-193099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPROG to ANDST (Xenopus tropicalis)
RHEA:59912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H2O + NADP(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH
RHEA:68717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + germacrene D
RHEA:61224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-asparagine + O2 = 2-oxosuccinamate + H2O2 + NH4(+)
REACT:R-XTR-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Xenopus tropicalis)
RHEA:38857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O => a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:17490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + phthalate => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)
REACT:R-GGA-8855508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Gallus gallus)
RHEA:56925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]
GO:0099620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-Ara4O aminotransferase
GO:0099620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase
GO:0099620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase
GO:0099620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO:0099620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase
GO:0099620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-L-Ara4N transaminase
REACT:R-BTA-975903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Bos taurus)
RHEA:63178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ibuprofenoyl-CoA => (2S)-ibuprofenoyl-CoA
REACT:R-DRE-5358336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB forms mixed disulphides with Hh precursors (Danio rerio)
REACT:R-RNO-201629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Tau (Rattus norvegicus)
REACT:R-SSC-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Sus scrofa)
REACT:R-CEL-1299297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of THIK (Caenorhabditis elegans)
REACT:R-SSC-5683964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates EYA1-4 (Sus scrofa)
REACT:R-HSA-202726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F11R dimerises (Homo sapiens)
REACT:R-RNO-2028583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS2 (Rattus norvegicus)
REACT:R-SSC-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Sus scrofa)
RHEA:29604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-MMU-9029150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Mus musculus)
REACT:R-DRE-5661217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds zinc (Danio rerio)
REACT:R-GGA-428752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:Gq complex (Gallus gallus)
RHEA:20582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + NH4(+) => 2 H(+) + hydroxylamine + NADH
RHEA:52639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 <=> a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate
REACT:R-BTA-9714691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds ER effectors (Bos taurus)
REACT:R-RNO-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Rattus norvegicus)
REACT:R-GGA-9647643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds bacterial cardiolipin (Gallus gallus)
REACT:R-MMU-3000449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Mus musculus)
REACT:R-CFA-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Canis familiaris)
RHEA:24201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + H(+) => aniline + CO2
REACT:R-GGA-8847968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN binds FRK (Gallus gallus)
RHEA:65118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene A + CO2 + H2O + succinate => 2-oxoglutarate + aculene B + O2
RHEA:50443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H1 <=> prostaglandin D1
REACT:R-HSA-983425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Homo sapiens)
RHEA:20659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorophenylacetate + NH4(+) => 4-chlorophenylacetonitrile + 2 H2O
RHEA:61858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone C + 3 H2O + 3 NADP(+) => dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2
REACT:R-DME-209231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOME:HOP complex forms a dimer at the plasma membrane (Drosophila melanogaster)
REACT:R-HSA-2197770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1 (FEEL-1) binds ligands (Homo sapiens)
REACT:R-MMU-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Mus musculus)
REACT:R-MMU-417858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y14 receptor can bind to UDP-glucose (Mus musculus)
RHEA:52954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholoyl-24-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate
GO:0035034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase regulator activity
GO:0035034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase regulator activity
REACT:R-DRE-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Danio rerio)
REACT:R-DRE-216068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with Tenascin-C (Danio rerio)
REACT:R-DRE-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Danio rerio)
REACT:R-PFA-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)
RHEA:23811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Xenopus tropicalis)
RHEA:43752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[ribosomal protein S5]-alanine N-acetyltransferase"
RHEA:43752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]
RHEA:43752	skos:prefLabel	"[ribosomal protein S5]-alanine N-acetyltransferase"
REACT:R-HSA-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Homo sapiens)
REACT:R-CFA-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)
RHEA:31330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol <=> bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)
RHEA:47881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioctanoylglycerol + H2O => H(+) + octanoate + octanoylglycerol
REACT:R-HSA-182171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of CD8 (Homo sapiens)
REACT:R-HSA-9686338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 3a binds the lysosomal membrane (Homo sapiens)
REACT:R-CEL-156661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Exon Junction Complex (Caenorhabditis elegans)
REACT:R-CFA-5333678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPNEs bind PL (Canis familiaris)
REACT:R-HSA-8849055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARHGAP35 (Homo sapiens)
REACT:R-RNO-8864125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Rattus norvegicus)
REACT:R-DRE-2309773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS2 (Danio rerio)
GO:0015295	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	low affinity metal ion uptake transporter activity
GO:0015295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:proton symporter activity
GO:0015295	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-idonate/D-gluconate:hydrogen symporter activity
GO:0015295	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proline/glycine/betaine:hydrogen/sodium symporter activity
GO:0015295	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	high affinity metal ion uptake transporter activity
GO:0015295	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heavy metal ion:hydrogen symporter activity
GO:0015295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:hydrogen symporter activity
RHEA:72376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(out) + iodide(in) => hydrogencarbonate(in) + iodide(out)
REACT:R-HSA-9011961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GREB1 translation is negatively regulated by miR-26A and B (Homo sapiens)
RHEA:68350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + pppA(2'-5')pG => ATP + GTP
REACT:R-DRE-5627072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds GOPC:CFTR (Danio rerio)
REACT:R-BTA-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Bos taurus)
RHEA:11305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate => glyoxylate + urea
RHEA:48644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde
RHEA:39816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate => (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:67014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate => a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+)
RHEA:33651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
REACT:R-MMU-4615900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB2 with SUMO3 (Mus musculus)
REACT:R-SPO-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Schizosaccharomyces pombe)
REACT:R-BTA-433698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
REACT:R-CEL-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Caenorhabditis elegans)
REACT:R-RNO-5607732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TAK1 autophosphorylates (Rattus norvegicus)
REACT:R-BTA-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Bos taurus)
REACT:R-GGA-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Gallus gallus)
REACT:R-CEL-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Caenorhabditis elegans)
REACT:R-DME-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-PFA-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Plasmodium falciparum)
RHEA:68682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate)
RHEA:52118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA
RHEA:47255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Saccharomyces cerevisiae)
REACT:R-BTA-111746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Bos taurus)
REACT:R-BTA-2176445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD2 (Bos taurus)
REACT:R-SCE-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Saccharomyces cerevisiae)
RHEA:55977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + thiosulfate => H(+) + S-sulfanylglutathione + sulfite
RHEA:15808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-7,8-diammoniononanoate + ATP + CO2 <=> (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate
REACT:R-GGA-5610732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI3 (Gallus gallus)
RHEA:55203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine <=> 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine
REACT:R-CFA-446868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Interleukin 1 receptor complex binds Tollip (Canis familiaris)
REACT:R-BTA-8981534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin dimer:KIRREL binds FYN (Bos taurus)
REACT:R-MMU-375384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bombesin-like receptors bind bombesin homologues (Mus musculus)
REACT:R-MMU-5651739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Mus musculus)
RHEA:67949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP
REACT:R-SSC-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Sus scrofa)
RHEA:66853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
RHEA:25322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
RHEA:14858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + ATP + L-lysine => ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate
REACT:R-RNO-8852013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL8 binds resting T cell surface (Rattus norvegicus)
RHEA:62244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine(6-4)thymidine in DNA = a cytidine-thymine dinucleotide in DNA
REACT:R-DME-975594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLB1 hydrolyses RPALM to atROL (Drosophila melanogaster)
REACT:R-RNO-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Rattus norvegicus)
REACT:R-CFA-8952749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Canis familiaris)
REACT:R-MMU-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Mus musculus)
REACT:R-SSC-508513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B binds JAK3 (Sus scrofa)
REACT:R-GGA-166869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MEKK1 (Gallus gallus)
REACT:R-MMU-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Mus musculus)
REACT:R-BTA-193369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Bos taurus)
REACT:R-DRE-202394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CARMA1 to Plasma membrane (Danio rerio)
REACT:R-RNO-2424246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind lecticans (Rattus norvegicus)
RHEA:15530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(2-ethylhexyl)phthalate + H2O => 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)
REACT:R-MMU-1307963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Mus musculus)
REACT:R-MMU-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Mus musculus)
RHEA:27587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + pyruvate => indole-3-pyruvate + L-alanine
RHEA:49531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethylene terephthalate)(n) + H2O <=> (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)
REACT:R-HSA-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)
REACT:R-BTA-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
RHEA:25321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
REACT:R-BTA-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Bos taurus)
REACT:R-DRE-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Danio rerio)
REACT:R-DME-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Drosophila melanogaster)
GO:0050339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxythymidine-5'-triphosphatase activity
GO:0050339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine triphosphatase activity
GO:0050339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTTPase activity
GO:0050339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTTP nucleotidohydrolase activity
GO:0050339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine triphosphate nucleotidohydrolase activity
GO:0050339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPase activity
GO:0050339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine-triphosphatase activity
REACT:R-HSA-1971483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Homo sapiens)
REACT:R-RNO-389348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by pVav1 (Rattus norvegicus)
RHEA:36566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-colitose + NADP(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH
REACT:R-CFA-199518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3d-complexed antigen binds to complement receptor (Canis familiaris)
RHEA:12616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + L-cystine <=> glutathione disulfide + 2 L-cysteine
REACT:R-BTA-416698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA5A binds to PLXNB3 (Bos taurus)
REACT:R-MMU-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Mus musculus)
REACT:R-DRE-1632843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1 binds DYNLL1,DYNLL2 (Danio rerio)
REACT:R-CFA-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Canis familiaris)
REACT:R-SSC-171122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL + LDLR => LDL:LDLR complex (Sus scrofa)
REACT:R-HSA-77327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Homo sapiens)
GO:0102667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-beta-1-D-glucose hydrolase activity
REACT:R-DDI-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Dictyostelium discoideum)
RHEA:72926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III
RHEA:64799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)
RHEA:27556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 2 diphosphate
RHEA:66842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-CEL-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Caenorhabditis elegans)
REACT:R-BTA-5362486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Bos taurus)
RHEA:30330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SPO-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Schizosaccharomyces pombe)
RHEA:45733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + L-tyrosine => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate
RHEA:25725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
GO:0102062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-santalene synthase activity
REACT:R-GGA-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Gallus gallus)
RHEA:31727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 + styrene = (2S)-2-phenyloxirane + FAD + H(+) + H2O
RHEA:31727	skos:prefLabel	"styrene monooxygenase"
RHEA:31727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"styrene monooxygenase"
RHEA:38298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2
REACT:R-HSA-9676071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
RHEA:23323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophan + malonyl-CoA <=> CoA + H(+) + N(2)-malonyl-D-tryptophan
REACT:R-BTA-2130619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosomal vesicle coat assembly (Bos taurus)
GO:0032041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone H3-K14 deacetylase activity
GO:0032041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone H3K14 deacetylase activity
REACT:R-SSC-174132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Cyclin B:Cdc2 (Sus scrofa)
REACT:R-DRE-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Danio rerio)
REACT:R-SSC-6799191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Sus scrofa)
REACT:R-HSA-8863011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p25-bound CDK5 phosphorylates CDC25C (Homo sapiens)
RHEA:67308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one
RHEA:51380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + dopamine = CoA + H(+) + N-(9Z-octadecanoyl)-dopamine
REACT:R-CFA-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Canis familiaris)
REACT:R-GGA-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Gallus gallus)
RHEA:64440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycylglycyl-L-proline(out) + H(+)(out) = glycylglycyl-L-proline(in) + H(+)(in)
REACT:R-HSA-8878220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the NOTCH1 coactivator complex (Homo sapiens)
REACT:R-GGA-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Gallus gallus)
REACT:R-HSA-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Homo sapiens)
REACT:R-MMU-9635739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 dephosphorylates p-T,Y-MAPKs (Mus musculus)
RHEA:29244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinone-8 + NADH => menaquinol-8 + NAD(+)
RHEA:51333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 => 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate
RHEA:21107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cholesterol + O2 <=> 25-hydroxycholesterol + A + H2O
RHEA:32406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S,4R)-neodihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH
REACT:R-GGA-9690494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB translocates to the endosome membrane (Gallus gallus)
RHEA:11435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside <=> 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-391942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP receptor can bind prostacyclin (Sus scrofa)
REACT:R-DME-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)
REACT:R-HSA-8954110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1:EPC1 binds the PRC2 complex (Homo sapiens)
RHEA:18253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NADP(+) = CO2 + NADPH + pyruvate
RHEA:45585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-(1,3/6)-mannosidase activity
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ManII activity
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Golgi alpha-mannosidase II
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-mannosidase II
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mannosidase II activity
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-mannosidase II
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,3-1,6-alpha-mannosidase activity
GO:0004572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
RHEA:58475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate
REACT:R-RNO-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Rattus norvegicus)
REACT:R-XTR-5607723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Xenopus tropicalis)
RHEA:56789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[corrinoid adenosyltransferase] + cob(II)alamin => cob(II)alamin-[corrinoid adenosyltransferase]
REACT:R-CEL-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Caenorhabditis elegans)
REACT:R-DDI-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Dictyostelium discoideum)
REACT:R-RNO-5607002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor VIIIa (Rattus norvegicus)
RHEA:54581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end dephospho-ribonucleoside-RNA + ATP => a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)
REACT:R-RNO-187828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p21 to the nucleus (Rattus norvegicus)
REACT:R-CEL-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Caenorhabditis elegans)
RHEA:62897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)
REACT:R-BTA-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Bos taurus)
REACT:R-BTA-5633051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFCAB7:IQCE binds EVC2:EVC (Bos taurus)
RHEA:61860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroprobetaenone I + H(+) + NADPH + O2 = epoxybetaenone + H2O + NADP(+)
RHEA:70984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(out) + n H(+)(in) => glycine(in) + n H(+)(out)
RHEA:13786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA => H2O + itaconyl-CoA
RHEA:39775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-6807224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-BGLAP to BGLAP (Gallus gallus)
GO:0140584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin extrusion motor activity
GO:0140584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin extrusion activity
REACT:R-HSA-6804383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 methylates TP53 (Homo sapiens)
RHEA:67617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GTP + H2O => 8-oxo-GMP + diphosphate + H(+)
RHEA:46277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + H(+) => (S)-lactate + CO2
REACT:R-BTA-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Bos taurus)
REACT:R-HSA-174132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)
REACT:R-BTA-388808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-2 monomer (Bos taurus)
RHEA:58504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = (3Z)-2-oxo-4-carboxy-3-hexenedioate
RHEA:19772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phaseollidin hydrate <=> H2O + phaseollidin
REACT:R-SPO-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Schizosaccharomyces pombe)
RHEA:32118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + DIBOA beta-D-glucoside + O2 <=> CO2 + succinate + TRIBOA beta-D-glucoside
REACT:R-BTA-8939335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 polyubiquinates BCL10 (Bos taurus)
RHEA:60956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP
RHEA:21249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + RNA(n) => diphosphate + RNA(n+1)
REACT:R-BTA-8951676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TEADs and YAP1 (Bos taurus)
RHEA:47983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose
RHEA:72810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(out) <=> L-histidine(in)
RHEA:39013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol(out) => a triacyl-sn-glycerol(in)
REACT:R-HSA-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Homo sapiens)
REACT:R-DRE-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Danio rerio)
REACT:R-GGA-391913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR2 binds FPR2 ligands (Gallus gallus)
REACT:R-BTA-6786789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer binds FLT3 (Bos taurus)
REACT:R-HSA-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Homo sapiens)
REACT:R-GGA-9610154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)
REACT:R-CFA-111253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Canis familiaris)
GO:0120017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide carrier activity
GO:0120017	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ceramide transporter activity
GO:0120017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide transfer activity
GO:0120017	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane ceramide transfer activity
RHEA:36056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-amino-4-hydroxypteridine + H(+) + H2O => a 2,4-dihydroxypteridine + NH4(+)
GO:0052727	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	capsanthin-capsorubin synthase activity
GO:0052727	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ketoxanthophyll synthase activity
GO:0052727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	capsanthin synthase activity
GO:0052727	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CCS
RHEA:68876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + piperonylate = AMP + diphosphate + NADP(+) + piperonal
REACT:R-GGA-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Gallus gallus)
REACT:R-RNO-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Rattus norvegicus)
REACT:R-DRE-1297338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of ADAM and B4GALT1 With ZP3 (Danio rerio)
GO:1990846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleoside-diphosphate reductase inhibitor activity
REACT:R-GGA-879201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bcl-2 and Bcl-XL bind NLRP1 (Gallus gallus)
REACT:R-RNO-2162226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Rattus norvegicus)
RHEA:65132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + preaustinoid A1 = CO2 + H2O + preaustinoid A2 + succinate
RHEA:25727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-6804425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F2 (Rattus norvegicus)
REACT:R-DDI-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Dictyostelium discoideum)
RHEA:30276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H2O2 => A + 2 H2O
RHEA:14690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorophenylacetate + NADH + O2 => 3,4-dihydroxyphenylacetate + chloride + NAD(+)
REACT:R-DRE-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Danio rerio)
REACT:R-CFA-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Canis familiaris)
RHEA:10633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NAD(+) => D-mannuronate + H(+) + NADH
REACT:R-CFA-429581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 transports vitamins from extracellular region to cytosol (Canis familiaris)
REACT:R-MMU-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Mus musculus)
RHEA:63166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine + tricosanoate => H2O + N-tricosanoyl-taurine
REACT:R-HSA-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Homo sapiens)
RHEA:57571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ethylmalonyl-CoA + NADP(+) => (2E)-butenoyl-CoA + CO2 + NADPH
REACT:R-CFA-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Canis familiaris)
REACT:R-SSC-983422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of COPII coated vesicle (Sus scrofa)
RHEA:50128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D1 = 17-oxoresolvin D1 + H(+) + NADH
RHEA:66320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP(out) = 2',3'-cGAMP(in)
REACT:R-PFA-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)
RHEA:23728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2
RHEA:23728	skos:altLabel	"prostaglandin synthetase"
RHEA:23728	skos:altLabel	"prostaglandin synthase"
RHEA:23728	skos:altLabel	"prostaglandin G/H synthase"
RHEA:23728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prostaglandin-endoperoxide synthase"
RHEA:23728	skos:prefLabel	"prostaglandin-endoperoxide synthase"
RHEA:23728	skos:altLabel	"PG synthetase"
REACT:R-MMU-352232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)
RHEA:53529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-HSA-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Homo sapiens)
RHEA:51971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate
REACT:R-CFA-8867044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
REACT:R-RNO-2046092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Rattus norvegicus)
GO:0031208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTB domain
GO:0031208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POZ domain binding
GO:0031208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	broad-complex, tramtrack, and bric-a-brac domain binding
RHEA:42903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(745) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-DRE-174967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT2 acetylation (Danio rerio)
REACT:R-RNO-391153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds GRB2-1 (Rattus norvegicus)
REACT:R-HSA-4088322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GNE does not phosphorylate ManNAc to ManNAc-6-P (Homo sapiens)
RHEA:23293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-lombricine => ADP + H(+) + N-phospho-L-lombricine
REACT:R-XTR-5653878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Xenopus tropicalis)
REACT:R-SSC-8950757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Sus scrofa)
REACT:R-DME-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Drosophila melanogaster)
REACT:R-HSA-9730767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monofunctional chemotherapeutic alkylating drugs produce 7-methylguanine in dsDNA (Homo sapiens)
REACT:R-BTA-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-CEL-2066780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)
RHEA:36777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose
RHEA:30556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-glutamate + oxidized coenzyme F420-0 => GDP + H(+) + oxidized coenzyme F420-1 + phosphate
RHEA:69177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]
RHEA:41255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate
RHEA:22297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate => (1R,2R,3R)-prephytoene diphosphate + diphosphate
RHEA:26433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O <=> diphosphate + phyllocladan-16alpha-ol
REACT:R-SSC-870449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 monoubiquitinates SMAD4 (Sus scrofa)
REACT:R-BTA-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)
RHEA:72305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(out) + L-thyroxine(in) => L-glutamate(in) + L-thyroxine(out)
REACT:R-SSC-9603987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Sus scrofa)
REACT:R-XTR-204871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb2 (Xenopus tropicalis)
RHEA:66612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA = methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]
GO:0098608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylselenol demethylase activity
GO:0098608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeH is hydrolysed to H2Se by methylselenol demethylase (Homo sapiens)
REACT:R-RNO-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Rattus norvegicus)
REACT:R-RNO-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Rattus norvegicus)
GO:0140103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalytic activity, acting on a glycoprotein
REACT:R-CEL-4615872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO1 (Caenorhabditis elegans)
REACT:R-HSA-5660665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 binds MALT (Homo sapiens)
REACT:R-BTA-428752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:Gq complex (Bos taurus)
RHEA:52547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythronate + NAD(+) <=> 2-dehydro-D-erythronate + H(+) + NADH
REACT:R-BTA-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Bos taurus)
REACT:R-SCE-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Saccharomyces cerevisiae)
REACT:R-CFA-3222006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STK11 (LKB1) phosphorylates NUAK1 (Canis familiaris)
RHEA:33558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + H2O <=> (4R)-hydroxysphinganine + a fatty acid
REACT:R-RNO-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Rattus norvegicus)
REACT:R-DRE-380294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of C-Nap-1 from centrosomes (Danio rerio)
RHEA:52788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a + 2 H(+) = Mg(2+) + pheophytin a
RHEA:56303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]
RHEA:29572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-idonate(in) => H(+)(out) + L-idonate(out)
RHEA:10840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-homoserine = L-threonine + phosphate
RHEA:10840	skos:prefLabel	"threonine synthase"
RHEA:10840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"threonine synthase"
RHEA:40572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
GO:0008697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity
GO:0008697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-keto-4-deoxyuronate isomerase activity
GO:0008697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity
GO:0008697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-deoxy-L-threo-5-hexulose uronate isomerase activity
RHEA:47885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
REACT:R-MMU-2032396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3 migrates to the nucleus (Mus musculus)
REACT:R-HSA-9647643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds bacterial cardiolipin (Homo sapiens)
REACT:R-DRE-8868230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNX9 recruits components of the actin polymerizing machinery (Danio rerio)
GO:0015621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric triacetylfusarinine C transmembrane transporter activity
REACT:R-CEL-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Caenorhabditis elegans)
RHEA:50190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2
REACT:R-DME-2534248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP2, MMP3, MMP7 (Drosophila melanogaster)
REACT:R-XTR-1306957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)
RHEA:43150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine => adenosine(9) in tRNA + S-adenosyl-L-methionine
REACT:R-RNO-5620921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Rattus norvegicus)
REACT:R-XTR-373738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin interacts with syntenin-1 (Xenopus tropicalis)
REACT:R-GGA-5693542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RPA complexes with ssDNA at resected DNA DSBs (Gallus gallus)
REACT:R-XTR-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Xenopus tropicalis)
RHEA:41950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate
RHEA:62071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose 6-phosphate + NADP(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
REACT:R-DDI-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Dictyostelium discoideum)
REACT:R-RNO-8956684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH polyubiquitinates TP73 (Rattus norvegicus)
REACT:R-BTA-6799179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)
REACT:R-MMU-174105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated cell cycle proteins (Mus musculus)
RHEA:49127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + protodeoxyviolaceinate <=> H2O + NADP(+) + protoviolaceinate
RHEA:53035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:25636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laricitrin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + syringetin
REACT:R-SSC-3204318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Sus scrofa)
RHEA:71857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurochenodeoxycholate(in) => taurochenodeoxycholate(out)
REACT:R-XTR-2187309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer binds SP1 (Xenopus tropicalis)
REACT:R-GGA-159757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)
RHEA:51291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
RHEA:38669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine 1-phosphate(out) => sphing-4-enine 1-phosphate(in)
RHEA:66070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine
REACT:R-MMU-9750555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Mus musculus)
RHEA:54273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate
RHEA:35283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA = (2E)-octadecenoyl-CoA
RHEA:47410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O
RHEA:22753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + uracil => AH2 + barbiturate + H(+)
GO:0106144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fraxetin 5-hydroxylase activity
RHEA:38672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate(in) => sphinganine 1-phosphate(out)
REACT:R-SCE-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Saccharomyces cerevisiae)
REACT:R-XTR-6810594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)
REACT:R-DRE-2130378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex to plasma membrane (Danio rerio)
REACT:R-BTA-391153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds GRB2-1 (Bos taurus)
REACT:R-DRE-5696914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP28 deubiquitinates CLSPN and MYC (Danio rerio)
REACT:R-MMU-9706340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y-GRB10 binds PIK3R1 (Mus musculus)
RHEA:52843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vanillate <=> 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP
RHEA:42588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-BTA-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Bos taurus)
REACT:R-HSA-9033478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin (Homo sapiens)
REACT:R-RNO-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Rattus norvegicus)
REACT:R-BTA-174452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha on the C-strand of the telomere (Bos taurus)
REACT:R-SSC-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Sus scrofa)
RHEA:69879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] = castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Rattus norvegicus)
REACT:R-RNO-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Rattus norvegicus)
RHEA:64255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycine
RHEA:48589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin B4
REACT:R-SSC-2855020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Sus scrofa)
REACT:R-SSC-452100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to IL2 receptor is phosphorylated (Sus scrofa)
RHEA:21188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(+) synthase"
RHEA:21188	skos:prefLabel	"NAD(+) synthase"
RHEA:21188	skos:altLabel	"NAD(+) synthetase"
RHEA:21188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)
RHEA:54944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)
REACT:R-GGA-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Gallus gallus)
REACT:R-SPO-8847638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Schizosaccharomyces pombe)
RHEA:18300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phtalamide + H2O <=> a primary amine + phthalate
REACT:R-DRE-426223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cation influx mediated by TRPC3/6/7 (Danio rerio)
RHEA:69049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexano-6-lactone => 6-hydroxyhexanoate + H(+)
REACT:R-CFA-5654705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
REACT:R-XTR-5654679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR3 (Xenopus tropicalis)
REACT:R-HSA-9755303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades HIFalpha (Homo sapiens)
REACT:R-MMU-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Mus musculus)
REACT:R-RNO-8987223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10RB binds TYK2 (Rattus norvegicus)
RHEA:60123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine <=> H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine
REACT:R-MMU-202706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha4beta1 binds JAM2:JAM3 (Mus musculus)
REACT:R-SSC-3878123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of SAHF formation (Sus scrofa)
EC:3.4.24.56	skos:altLabel	"insulin-degrading enzyme"
EC:3.4.24.56	skos:altLabel	"insulin protease"
EC:3.4.24.56	skos:prefLabel	"insulysin"
EC:3.4.24.56	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"insulysin"
EC:3.4.24.56	skos:altLabel	"insulinase"
REACT:R-RNO-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
REACT:R-DRE-5634729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Danio rerio)
REACT:R-BTA-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Bos taurus)
REACT:R-BTA-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Bos taurus)
RHEA:12705	skos:altLabel	"L-isoaspartyl protein carboxyl methyltransferase"
RHEA:12705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-L-isoaspartate(D-aspartate) O-methyltransferase"
RHEA:12705	skos:prefLabel	"protein-L-isoaspartate(D-aspartate) O-methyltransferase"
RHEA:12705	skos:altLabel	"protein L-isoaspartyl methyltransferase"
RHEA:12705	skos:altLabel	"protein D-aspartate methyltransferase"
RHEA:12705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine
RHEA:12705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-D-aspartate + S-adenosyl-L-methionine = [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine
RHEA:12705	skos:altLabel	"protein beta-aspartate O-methyltransferase"
RHEA:28016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl thiocyanate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + thiocyanate
RHEA:53699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
RHEA:54333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-DME-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Drosophila melanogaster)
RHEA:54822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine
RHEA:13204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-arginine <=> guanidinoacetate + L-ornithine
REACT:R-CFA-2396606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)
GO:0018671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate-3-hydroxylase activity
GO:0018671	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	4-hydroxybenzoate 3-hydroxylase activity
GO:0018671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity
GO:0018671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)
GO:0018671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))
REACT:R-HSA-205075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JNK phosphorylates BIM, BAD and other targets (Homo sapiens)
RHEA:27953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(in) <=> L-phenylalanine(out)
REACT:R-HSA-9612980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF in Rap1-GTP complex:BRAF complex autophosphorylates (Homo sapiens)
REACT:R-BTA-1168640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated IkB is degraded (Bos taurus)
REACT:R-GGA-5690856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)
REACT:R-HSA-177943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to EGF:EGFR complex (Homo sapiens)
RHEA:18474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP
REACT:R-SSC-5665761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL3 binds RHOC:GTP (Sus scrofa)
EC:3.4.22.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"clostripain"
EC:3.4.22.8	skos:altLabel	"clostridiopeptidase B"
EC:3.4.22.8	skos:prefLabel	"clostripain"
RHEA:70458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2
GO:0016757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring glycosyl groups
GO:0016757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transglycosidase activity
GO:0016757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosyltransferase activity
GO:0016757	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transferase activity, transferring other glycosyl groups
GO:0016757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transglycosylase activity
RHEA:28290	skos:altLabel	"farnesyl pyrophosphate:drimenol cyclase"
RHEA:28290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (5S,9S,10S)-drim-7-en-11-ol + diphosphate
RHEA:28290	skos:prefLabel	"(-)-drimenol synthase"
RHEA:28290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-drimenol synthase"
RHEA:28290	skos:altLabel	"drimenol cyclase"
GO:0015441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent beta-glucan transporter activity
GO:0015441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled beta-glucan transporter activity
GO:0015441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucan ABC transporter
GO:0015441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ABC-type beta-glucan transporter
GO:0015441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type beta-glucan transporter activity
GO:0015441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glucan-transporting ATPase activity
RHEA:15592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-4-hydroxyphenylglycine <=> 4-hydroxyphenylglyoxylate + L-glutamate
RHEA:46455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-leucyl-tRNA(Leu) <=> cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)
REACT:R-GGA-174931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Gallus gallus)
REACT:R-HSA-5663170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds BHLHE40 gene (Homo sapiens)
GO:0070260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-tyrosyl-DNA phosphodiesterase activity
REACT:R-RNO-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Rattus norvegicus)
REACT:R-RNO-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
REACT:R-SSC-2404134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4:atROL binds TTR (Sus scrofa)
GO:0047746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllase activity
GO:0047746	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorophyll chlorophyllidohydrolase activity
RHEA:43529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NAD(+) => 2-aminomalonate semialdehyde + H(+) + NADH
GO:0005143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-12 receptor binding
GO:0005143	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-12 receptor ligand
GO:0005143	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-12
REACT:R-CFA-3229102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPKAPK3 phosphorylates BMI1 (Canis familiaris)
RHEA:11552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylalkylglycerol acetylhydrolase"
RHEA:11552	skos:altLabel	"alkylacetylglycerol acetylhydrolase"
RHEA:11552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + acetate + H(+)
RHEA:11552	skos:prefLabel	"acetylalkylglycerol acetylhydrolase"
REACT:R-BTA-8938867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND3,(CCND1,CCND2) binds RUNX1 (Bos taurus)
REACT:R-CEL-2671885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers:H+ transport extracellular Na+ to cytosol (Caenorhabditis elegans)
REACT:R-XTR-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Xenopus tropicalis)
REACT:R-CFA-1472121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of p-KIT on Y900 by Src kinases (Canis familiaris)
GO:0090681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein-coupled taste receptor activity
GO:0090681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled taste receptor activity
GO:0090681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR taste receptor activity
GO:0043778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin 8 methylmutase activity
GO:0043778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin-8X methylmutase activity
GO:0043778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin 8X methylmutase activity
GO:0043778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin-8 methylmutase activity
REACT:R-MMU-5226904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Mus musculus)
RHEA:30149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 H(+) + NADH => FADH2 + NAD(+)
REACT:R-HSA-389158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-RNO-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Rattus norvegicus)
REACT:R-DDI-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Dictyostelium discoideum)
REACT:R-HSA-8985097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAS2 dimerizes (Homo sapiens)
REACT:R-HSA-5213466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is phosphorylated (Homo sapiens)
RHEA:68075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH <=> L-thiazolidine-2-carboxylate + NADP(+)
REACT:R-CFA-5690740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds B-cell receptor (Canis familiaris)
REACT:R-DRE-2671885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers:H+ transport extracellular Na+ to cytosol (Danio rerio)
REACT:R-DRE-5688786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds RAD23 (Danio rerio)
GO:0005095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTPase inhibitor activity
GO:0005095	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GIP
RHEA:56135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA <=> a thymidine dimer in DNA
REACT:R-DRE-5686475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Danio rerio)
REACT:R-DRE-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
RHEA:13403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesol => (2E,6E)-farnesol
REACT:R-SPO-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Schizosaccharomyces pombe)
REACT:R-BTA-5654684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR4 (Bos taurus)
REACT:R-DRE-5654634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates SHC1 (Danio rerio)
REACT:R-CFA-174731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of newly synthesized ApoB-48 (Canis familiaris)
REACT:R-MMU-2168897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP1 (CD91) binds Hemopexin:heme (Mus musculus)
REACT:R-BTA-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Bos taurus)
REACT:R-MMU-2168889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin-related Protein binds Hemoglobin (Mus musculus)
REACT:R-BTA-9667563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR2 bind desmopressin (Bos taurus)
REACT:R-DDI-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Dictyostelium discoideum)
RHEA:19775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate
REACT:R-CFA-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Canis familiaris)
GO:0031840	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 neuromedin U receptor ligand
GO:0031840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 neuromedin U receptor binding
RHEA:64631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + octan-1-ol <=> CoA + octyl acetate
REACT:R-DDI-5649723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Dictyostelium discoideum)
REACT:R-BTA-3323013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)
REACT:R-HSA-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Homo sapiens)
REACT:R-GGA-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Gallus gallus)
REACT:R-CFA-110375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Canis familiaris)
RHEA:23736	skos:prefLabel	"hydroxyisourate hydrolase"
RHEA:23736	skos:altLabel	"5-hydroxyisourate hydrolase"
RHEA:23736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyisourate hydrolase"
RHEA:23736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)
RHEA:23736	skos:altLabel	"HIUHase"
REACT:R-HSA-9035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysS248-MPST:TXN2 dissociates (Homo sapiens)
REACT:R-SSC-5654594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
RHEA:22224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O
RHEA:22224	skos:prefLabel	"acridone synthase"
RHEA:22224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acridone synthase"
GO:0004465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacylglycero-protein acylhydrolase activity
GO:0004465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diglyceride lipase activity
GO:0004465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diacylglycerol hydrolase activity
GO:0004465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	postheparin lipase activity
GO:0004465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	postheparin esterase activity
GO:0004465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	clearing factor lipase activity
GO:0004465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diacylglycerol lipase activity
GO:0004465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipemia-clearing factor
GO:0004465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoprotein lipase activity
REACT:R-SSC-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Sus scrofa)
REACT:R-HSA-266310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:spherical HDL complex <=> LCAT + spherical HDL (Homo sapiens)
RHEA:59646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylobionate + H(+) => D-xylobiono-1,5-lactone + H2O
RHEA:40881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-CFA-5333051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA1 binds HSF1 (Canis familiaris)
REACT:R-CFA-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Canis familiaris)
REACT:R-MMU-2730849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT (Mus musculus)
RHEA:56920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + ATP + H(+) = a medium-chain fatty acyl-AMP + diphosphate
REACT:R-GGA-2029268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of PLCG (Gallus gallus)
REACT:R-SPO-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Schizosaccharomyces pombe)
RHEA:72540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH
REACT:R-HSA-1299482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM23 SORT inserts proteins into inner membrane (Homo sapiens)
GO:0042881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactonate transmembrane transporter activity
REACT:R-XTR-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Xenopus tropicalis)
RHEA:67530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine => (6Z)-octenoyl-CoA + H2O
EC:3.4.22.52	skos:prefLabel	"calpain-1"
EC:3.4.22.52	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"calpain-1"
EC:3.4.22.52	skos:altLabel	"mu-calpain"
EC:3.4.22.52	skos:altLabel	"calcium-activated neutral protease I"
REACT:R-DME-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Drosophila melanogaster)
RHEA:54537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate
RHEA:44844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + eicosanoyl-CoA = CoA + O-eicosanoyl-(R)-carnitine
RHEA:68842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate => (2Z,6E)-farnesyl diphosphate
REACT:R-CFA-5689973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10,USP24,USP42 deubiquitinate TP53 (Canis familiaris)
REACT:R-SCE-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Saccharomyces cerevisiae)
RHEA:33838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexacosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + hexacosanoate
RHEA:37611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-HSA-74992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box (Homo sapiens)
REACT:R-SSC-6810474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Sus scrofa)
RHEA:32046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> 2 ATP + 2 H(+)
REACT:R-SSC-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Sus scrofa)
RHEA:33426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) <=> diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]
REACT:R-DME-450770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MWH binds to RHO1:GTP and is activated (Drosophila melanogaster)
RHEA:70985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + n H(+)(out) => glycine(out) + n H(+)(in)
RHEA:15195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + H(+) + triphosphate => dGTP + H2O
REACT:R-SCE-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Saccharomyces cerevisiae)
REACT:R-DRE-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Danio rerio)
REACT:R-MMU-445753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Mus musculus)
REACT:R-HSA-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)
REACT:R-SCE-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Saccharomyces cerevisiae)
REACT:R-DME-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Drosophila melanogaster)
REACT:R-HSA-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Homo sapiens)
REACT:R-BTA-1566962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by elastin-degrading extracellular proteinases (Bos taurus)
REACT:R-BTA-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Bos taurus)
REACT:R-PFA-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Plasmodium falciparum)
RHEA:65113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + aculene D + O2 => aculene C + CO2 + H2O + succinate
REACT:R-MMU-2022860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Mus musculus)
RHEA:54327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-RNO-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Rattus norvegicus)
REACT:R-RNO-216043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II binds integrin alpha10beta1 (Rattus norvegicus)
REACT:R-DDI-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)
REACT:R-SCE-392530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S400-Cot phosphorylates NIK (Saccharomyces cerevisiae)
REACT:R-BTA-8950537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)
RHEA:23621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(2)-(2-carboxyethyl)-L-arginine => AMP + deoxyamidinoproclavaminate + diphosphate + H(+)
GO:0047195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-diacyl-sn-glycerol:sterol acyl transferase activity
GO:0047195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity
GO:0047195	skos:prefLabel	"diacylglycerol--sterol O-acyltransferase"
GO:0047195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol-sterol O-acyltransferase activity
GO:0047195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diacylglycerol--sterol O-acyltransferase"
GO:0047195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a sterol = a 1-acyl-sn-glycerol + a sterol ester
REACT:R-HSA-171122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL + LDLR => LDL:LDLR complex (Homo sapiens)
REACT:R-XTR-5610742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI1 (Xenopus tropicalis)
REACT:R-PFA-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Plasmodium falciparum)
REACT:R-XTR-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Xenopus tropicalis)
REACT:R-XTR-2485182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Xenopus tropicalis)
REACT:R-CEL-351913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of TJP1 (Caenorhabditis elegans)
REACT:R-CFA-5693536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDC1 (Canis familiaris)
REACT:R-DME-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)
RHEA:25972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(8)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine
REACT:R-CEL-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Caenorhabditis elegans)
RHEA:45993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O
RHEA:54324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-CEL-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Caenorhabditis elegans)
RHEA:55923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[cis-1,4-isoprene](n) + O2 <=> (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)
REACT:R-GGA-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Gallus gallus)
REACT:R-DRE-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Danio rerio)
REACT:R-HSA-8877348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1, FOXP3 and NFATC2 bind the IL2 gene promoter (Homo sapiens)
REACT:R-DME-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Drosophila melanogaster)
RHEA:20954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose
RHEA:23569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-[ACP] => (3Z)-decenoyl-[ACP]
RHEA:30404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(3+)(out) + L-ascorbate(in) => Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)
REACT:R-RNO-390251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Rattus norvegicus)
REACT:R-RNO-1306963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Rattus norvegicus)
REACT:R-BTA-5624127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome target cargo to the primary cilium (Bos taurus)
REACT:R-MMU-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Mus musculus)
RHEA:60524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:22377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(38/39/40) in tRNA => pseudouridine(38/39/40) in tRNA
RHEA:46501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + UMP => CO2 + phosphate + succinate + uridine-5'-aldehyde
REACT:R-HSA-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Homo sapiens)
EC:1.1.1.359	skos:prefLabel	"aldose 1-dehydrogenase [NAD(P)(+)]"
EC:1.1.1.359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldose 1-dehydrogenase [NAD(P)(+)]"
REACT:R-BTA-4827382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Bos taurus)
REACT:R-DME-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-HSA-2029476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Role of myosins in phagosome formation (Homo sapiens)
REACT:R-BTA-5654673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Bos taurus)
REACT:R-CEL-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Caenorhabditis elegans)
REACT:R-RNO-3249390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Rattus norvegicus)
REACT:R-SPO-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Schizosaccharomyces pombe)
REACT:R-HSA-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
RHEA:33449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-methylzymosterol + CO2 + NADPH => 4beta-methylzymosterol-4alpha-carboxylate + NADP(+)
REACT:R-CFA-9709360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 reduces MetHb (Canis familiaris)
REACT:R-BTA-9693978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Small molecule inhibitor binds RIPK1, RIPK3 (Bos taurus)
REACT:R-BTA-166542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-NGF dimer binds to TrkA receptor (Bos taurus)
REACT:R-BTA-1602488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by plasmin and trypsin (Bos taurus)
RHEA:58932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH = 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)
RHEA:58932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aureothin polyketide synthase system"
RHEA:58932	skos:prefLabel	"aureothin polyketide synthase system"
RHEA:58932	skos:altLabel	"aureothin polyketide synthase complex"
REACT:R-DRE-183072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR non-clathrin mediated endocytosis (Danio rerio)
REACT:R-XTR-195664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Xenopus tropicalis)
RHEA:46698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine => a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine
REACT:R-CFA-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Canis familiaris)
GO:0047709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bis(2-ethylhexyl)phthalate acylhydrolase activity
GO:0047709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)
GO:0047709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(2-ethylhexyl)phthalate esterase activity
GO:0047709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DEHP esterase activity
GO:0047709	skos:prefLabel	"bis(2-ethylhexyl)phthalate esterase"
GO:0047709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bis(2-ethylhexyl)phthalate esterase"
REACT:R-DRE-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Danio rerio)
REACT:R-SSC-8851866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds RANBP10 (Sus scrofa)
REACT:R-CFA-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Canis familiaris)
REACT:R-GGA-77614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR1) (Gallus gallus)
REACT:R-MMU-2424485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-PLCG1 (Mus musculus)
RHEA:68683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) <=> 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SSC-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Sus scrofa)
REACT:R-GGA-5610723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind SUFU (Gallus gallus)
RHEA:20305	skos:altLabel	"4-hydroxybenzaldehyde dehydrogenase"
RHEA:20305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + H2O + NAD(+) = 4-hydroxybenzoate + 2 H(+) + NADH
RHEA:20305	skos:prefLabel	"4-hydroxybenzaldehyde dehydrogenase (NAD(+))"
RHEA:20305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzaldehyde dehydrogenase (NAD(+))"
RHEA:20305	skos:altLabel	"p-hydroxybenzaldehyde dehydrogenase"
EC:3.4.21.94	skos:altLabel	"PC2"
EC:3.4.21.94	skos:prefLabel	"proprotein convertase 2"
EC:3.4.21.94	skos:altLabel	"prohormone convertase II"
EC:3.4.21.94	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"proprotein convertase 2"
EC:3.4.21.94	skos:altLabel	"NEC 2"
EC:3.4.21.94	skos:altLabel	"neuroendocrine convertase 2"
RHEA:53235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-392835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 sequesters Raf1 to inhibit ERK cascade (Gallus gallus)
REACT:R-RNO-9023617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrylcholinesterase hydrolyzes acyl Ghrelin (Rattus norvegicus)
REACT:R-CEL-418091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB1 (Caenorhabditis elegans)
REACT:R-MMU-9627106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) forms dimer (Mus musculus)
REACT:R-CFA-3134946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 ubiquitination by TRIM21 (Canis familiaris)
REACT:R-MMU-8848023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds STAP2 (Mus musculus)
RHEA:27820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-L-idonate + H(+) + NADH => L-idonate + NAD(+)
REACT:R-DME-5654167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds PLCG1 (Drosophila melanogaster)
RHEA:11759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin + L-lysyl-[protein] <=> AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]
REACT:R-SPO-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Schizosaccharomyces pombe)
RHEA:56387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
REACT:R-SPO-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Schizosaccharomyces pombe)
RHEA:69001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine => 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-9014434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GAPs stimulate RHOG GTPase activity (Mus musculus)
REACT:R-MMU-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Mus musculus)
REACT:R-MMU-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Mus musculus)
RHEA:55687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + NH4(+) <=> 4-amino-4-deoxychorismate + H2O
REACT:R-HSA-9023941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)
RHEA:46317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-N,N'-diacetylbacillosamine + H2O => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)
REACT:R-MMU-8940100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates VCPIP1 (Mus musculus)
REACT:R-DRE-3134800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING dimerization (Danio rerio)
REACT:R-DRE-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)
REACT:R-HSA-9665726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds pertuzumab (Homo sapiens)
REACT:R-MMU-5686440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81:EME1,EME2 cleaves D-loop (Mus musculus)
REACT:R-DME-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)
REACT:R-DDI-9035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysS248-MPST:TXN2 dissociates (Dictyostelium discoideum)
REACT:R-RNO-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Rattus norvegicus)
REACT:R-BTA-5432849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds TLR4:LY96 (Bos taurus)
REACT:R-SPO-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Schizosaccharomyces pombe)
RHEA:42555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(31) in tRNA <=> pseudouridine(31) in tRNA
REACT:R-RNO-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Rattus norvegicus)
REACT:R-SPO-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Schizosaccharomyces pombe)
RHEA:70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate
REACT:R-GGA-8874202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the cytosol to the nucleus (Gallus gallus)
RHEA:34342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]
RHEA:56412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol
GO:0010858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent protein kinase regulator activity
REACT:R-SCE-9700701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T-type VDCC bind T-type VDCC blockers (Saccharomyces cerevisiae)
REACT:R-CFA-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Canis familiaris)
RHEA:69272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate = allyl isothiocyanate + sulfate
RHEA:44644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)
REACT:R-DRE-2152276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of transmembrane collagens (Danio rerio)
RHEA:54627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + octadecanoyl-CoA <=> 2-hydroxyoctadecanoyl-CoA + CO2 + succinate
REACT:R-RNO-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Rattus norvegicus)
REACT:R-HSA-9645520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Homo sapiens)
RHEA:63334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-arabinopyranose => alpha-L-arabinopyanose
RHEA:16603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + NH4(+) => L-aspartate
RHEA:52082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoate + H(+) + octadecanoate => 12-octadecanoyloxy-octadecanoate + H2O
REACT:R-DDI-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Dictyostelium discoideum)
RHEA:26141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)
GO:0004487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004487	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
GO:0004487	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate dehydrogenase activity
RHEA:11414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) => 6-hydroxymethyl-7,8-dihydropterin + ATP
GO:0102814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity
REACT:R-MMU-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Mus musculus)
REACT:R-XTR-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Xenopus tropicalis)
REACT:R-DRE-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Danio rerio)
EC:3.4.11.14	skos:altLabel	"aminopolypeptidase"
EC:3.4.11.14	skos:altLabel	"cytosol aminopeptidase III"
EC:3.4.11.14	skos:altLabel	"liver aminopeptidase"
EC:3.4.11.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytosol alanyl aminopeptidase"
EC:3.4.11.14	skos:altLabel	"arylamidase"
EC:3.4.11.14	skos:altLabel	"soluble alanyl aminopeptidase"
EC:3.4.11.14	skos:altLabel	"puromycin-sensitive aminopeptidase"
EC:3.4.11.14	skos:prefLabel	"cytosol alanyl aminopeptidase"
REACT:R-CEL-6807826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDHAL6B reduces PYR to LACT (Caenorhabditis elegans)
REACT:R-HSA-4641253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 ubiquitinates FZD to promote its downregulation (Homo sapiens)
REACT:R-XTR-947531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Xenopus tropicalis)
REACT:R-CFA-202939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of E-Cadherin (Canis familiaris)
REACT:R-DRE-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Danio rerio)
RHEA:17263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenol + H(+) + sulfate => an aryl sulfate + H2O
RHEA:66865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + quiannulatene
REACT:R-XTR-77301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Xenopus tropicalis)
REACT:R-PFA-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Plasmodium falciparum)
RHEA:35914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
RHEA:14520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA
REACT:R-BTA-8875451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates CBL (Bos taurus)
REACT:R-CFA-6814682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of early-endosome derived vesicles at the TGN (Canis familiaris)
REACT:R-DDI-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Dictyostelium discoideum)
RHEA:30029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NAD(+) => D-glyceraldehyde + H(+) + NADH
RHEA:66011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O
RHEA:66240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + IC-asc-C9 = AMP + diphosphate + IC-asc-C9-CoA
REACT:R-GGA-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Gallus gallus)
REACT:R-HSA-5389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)
GO:0045133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoate oxygenase activity
GO:0045133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate 3,4-dioxygenase activity
GO:0045133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoic oxygenase activity
GO:0045133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoate 1,2-dioxygenase activity
GO:0045133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-pyrocatechuate oxygenase activity
GO:0045133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)
RHEA:12930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + acetyl-CoA + H2O => (2R)-homocitrate + CoA + H(+)
REACT:R-GGA-2022399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Gallus gallus)
RHEA:41680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2
RHEA:72362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + succinate(out) <=> glutarate(out) + succinate(in)
RHEA:42459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methylzymosterol <=> zymosterol
RHEA:25981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-2855125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-1 binds to molecular patterns on the target cell surface (Sus scrofa)
RHEA:68732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-210974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS-1 to Tie2 bound  Grb2 (Sus scrofa)
REACT:R-BTA-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Bos taurus)
RHEA:13794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyleneglutarate => 2-methylene-3-methylsuccinate
GO:0005041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-density lipoprotein particle receptor activity
GO:0005041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	low-density lipoprotein receptor activity
GO:0005041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR activity
GO:0005041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL receptor
REACT:R-BTA-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
REACT:R-CFA-5621354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Canis familiaris)
GO:0072552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity
REACT:R-DRE-5218839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Danio rerio)
REACT:R-GGA-450358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Gallus gallus)
REACT:R-HSA-199299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO transcription factors (Homo sapiens)
RHEA:43727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]
RHEA:13195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+)
REACT:R-MMU-397891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:G12/13 (active) dissociate (Mus musculus)
EC:1.14.13.54	skos:prefLabel	"ketosteroid monooxygenase"
EC:1.14.13.54	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ketosteroid monooxygenase"
EC:1.14.13.54	skos:altLabel	"steroid-ketone monooxygenase"
REACT:R-HSA-210784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF1B-dependent synthesis of HNF6 protein (Homo sapiens)
REACT:R-HSA-5683583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10:ATG12:ATG7 dimer dissociates (Homo sapiens)
REACT:R-HSA-933537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TANK to TRAF6 (Homo sapiens)
RHEA:39167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA
RHEA:28688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + ubiquinone-8 => orotate + ubiquinol-8
REACT:R-RNO-192137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
RHEA:67506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:65762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-354165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS with GRB2 bound to FADK1 (Drosophila melanogaster)
RHEA:16617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->3)-D-glucose + phosphate = alpha-D-glucose 1-phosphate + D-glucose
RHEA:16617	skos:prefLabel	"laminaribiose phosphorylase"
RHEA:16617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"laminaribiose phosphorylase"
REACT:R-HSA-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Homo sapiens)
REACT:R-HSA-193369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Homo sapiens)
RHEA:28518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
RHEA:28518	skos:prefLabel	"D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase"
RHEA:28518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase"
REACT:R-HSA-400677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rnd1 interacts with Plexin-B1:Sema4D (Homo sapiens)
RHEA:41126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)
RHEA:44398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA
REACT:R-BTA-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Bos taurus)
RHEA:11488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA
RHEA:11488	skos:prefLabel	"retinol O-fatty-acyltransferase"
RHEA:11488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"retinol O-fatty-acyltransferase"
RHEA:33693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate
RHEA:40556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)
RHEA:32629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)
RHEA:33599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine
RHEA:31194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O
RHEA:66160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + tyramine = CoA + H(+) + N-hexanoyltyramine
REACT:R-MMU-377641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
REACT:R-DRE-8944263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type II (Danio rerio)
RHEA:60715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic alcohol + NAD(+) <=> (+)-artemisinic aldehyde + H(+) + NADH
RHEA:35078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	doxorubicin(in) + H(+)(out) <=> doxorubicin(out) + H(+)(in)
RHEA:64060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-phenylacetylcarbinol + NAD(+) = 1-phenyl-1,2-propanedione + H(+) + NADH
RHEA:66597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 2 tyramine => 2 dopamine
RHEA:57316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cytidine 5'-diphosphoramidate = ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)
RHEA:57316	skos:prefLabel	"cytidine diphosphoramidate kinase"
RHEA:57316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytidine diphosphoramidate kinase"
RHEA:55789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + H(+) + NADH + O2 => H2O + hydroxyacetone + NAD(+)
RHEA:50533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]
REACT:R-CEL-5324632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Caenorhabditis elegans)
REACT:R-HSA-9673322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm (Homo sapiens)
REACT:R-HSA-4396392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants bind HES1 promoter (Homo sapiens)
REACT:R-GGA-9700149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds PLCG1 (Gallus gallus)
GO:0102698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-epi-aristolochene synthase activity
REACT:R-DME-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Drosophila melanogaster)
REACT:R-DME-353125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteosome degrades ODC holoenzyme complex (Drosophila melanogaster)
RHEA:65673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine
RHEA:44176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-diacyl-sn-glycerol + H2O = 3-acyl-sn-glycerol + a fatty acid + H(+)
REACT:R-DDI-141200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates of PEA (Dictyostelium discoideum)
REACT:R-DDI-9033491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Dictyostelium discoideum)
RHEA:23159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime <=> (indol-3-yl)acetonitrile + H2O
RHEA:10626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + carbamoyl phosphate + 3 H(+) + phosphate => 2 ATP + CO2 + H2O + NH4(+)
REACT:R-BTA-5653878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Bos taurus)
REACT:R-CEL-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Caenorhabditis elegans)
GO:0033416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGG codon-amino acid adaptor activity
GO:0033416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan tRNA
GO:0033416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGG codon-amino acid adaptor activity
REACT:R-CEL-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Caenorhabditis elegans)
REACT:R-MMU-379464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DOPAC to form HVA (Mus musculus)
RHEA:14820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-maleylacetoacetate <=> 4-fumarylacetoacetate
REACT:R-HSA-6786095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates STAT3,STAT6 (Homo sapiens)
RHEA:18043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:20066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + 2-oxoglutarate + O2 => 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate
EC:3.1.22.2	skos:altLabel	"Aspergillus DNase K1"
EC:3.1.22.2	skos:prefLabel	"Aspergillus deoxyribonuclease K1"
EC:3.1.22.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Aspergillus deoxyribonuclease K1"
RHEA:52272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine = gramine + H(+) + S-adenosyl-L-homocysteine
RHEA:28760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose => alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)
REACT:R-DRE-450133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP binds MYD88 homodimer (Danio rerio)
RHEA:71378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + testosterone 17-sulfate(out) <=> 2 Na(+)(in) + testosterone 17-sulfate(in)
REACT:R-GGA-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Gallus gallus)
RHEA:36459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-proline + H2O = glycine + L-proline
REACT:R-RNO-1475028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Rattus norvegicus)
RHEA:50545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin C2 => prostaglandin B2
RHEA:49875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)
RHEA:45989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 => 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O
GO:0018502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity
RHEA:53942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2
REACT:R-SPO-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Schizosaccharomyces pombe)
REACT:R-CFA-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Canis familiaris)
REACT:R-CFA-9022314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates MECP2 (Canis familiaris)
REACT:R-SSC-2213210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen IX is cross-linked to the surface of collagen type II fibrils (Sus scrofa)
REACT:R-SSC-751039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (12/13) reassociates with G beta:gamma (Sus scrofa)
GO:0034895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridine-3,4-diol dioxygenase activity
REACT:R-BTA-444126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Bos taurus)
RHEA:48552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = (10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)
RHEA:55364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate
RHEA:40794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexacosanoyl-CoA <=> CoA + H(+) + hexacosanoate
REACT:R-DRE-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Danio rerio)
RHEA:37756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:63687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP <=> (4R,5S)-dethiobiotin + ADP + H(+) + phosphate
RHEA:47291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-216068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with Tenascin-C (Canis familiaris)
GO:0019808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyamine binding
RHEA:69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-alkenyl glucosinolate + H2O <=> a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)
REACT:R-DME-6784959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPHL hydrolyses VACV to ACV (Drosophila melanogaster)
REACT:R-MMU-193702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of the ICD migrates to the nucleus (Mus musculus)
REACT:R-RNO-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Rattus norvegicus)
REACT:R-SPO-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Schizosaccharomyces pombe)
RHEA:65873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,17beta-dihydroxyandrostan-3-one + A => 17beta-hydroxyandrostan-1,3-dione + AH2
REACT:R-MMU-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Mus musculus)
RHEA:52899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin <=> 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate
RHEA:41630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclooctat-9-en-7-ol + diphosphate => geranylgeranyl diphosphate + H2O
REACT:R-HSA-904830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
RHEA:69515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-galactosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-galactosaminate
RHEA:24159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoate + ATP <=> 2-methylpropanoyl phosphate + ADP
REACT:R-SCE-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Saccharomyces cerevisiae)
RHEA:60384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin + H2O = N-(2,3-dihydroxybenzoyl)-L-serine trimer
RHEA:60384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"apo-salmochelin esterase"
RHEA:60384	skos:prefLabel	"apo-salmochelin esterase"
RHEA:56424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-XTR-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Xenopus tropicalis)
RHEA:57261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + H(+) + lactate
REACT:R-SSC-8944216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XV (Sus scrofa)
REACT:R-DME-977301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histidine is decarboxylated to histamine (Drosophila melanogaster)
RHEA:18570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + H2O + O2 => an aromatic carboxylate + H(+) + H2O2
RHEA:53773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + lithocholoyl-CoA => chenodeoxycholoyl-CoA + lithocholate
RHEA:56629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O => chloride + 2 H(+) + maleylacetate
RHEA:62274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine => 4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine
RHEA:16138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + NADP(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADPH
RHEA:44012	skos:altLabel	"alpha-Kdo-(2->4)-alpha-(2->6)-lipid IVA palmitoleoyltransferase"
RHEA:44012	skos:prefLabel	"Kdo2-lipid IVA palmitoleoyltransferase"
RHEA:44012	skos:altLabel	"palmitoleoyl-acyl carrier protein-dependent acyltransferase"
RHEA:44012	skos:altLabel	"cold-induced palmitoleoyl transferase"
RHEA:44012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Kdo2-lipid IVA palmitoleoyltransferase"
RHEA:44012	skos:altLabel	"(Kdo)2-lipid IVA palmitoleoyltransferase"
RHEA:44012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP]
REACT:R-HSA-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Homo sapiens)
RHEA:69563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(out) + H(+)(out) <=> D-mannose(in) + H(+)(in)
REACT:R-HSA-4724291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALG6 does not add glucose to the N-glycan precursor (Homo sapiens)
RHEA:51133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a purine nucleobase
RHEA:61104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:67894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine
RHEA:12455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
REACT:R-HSA-6784423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Homo sapiens)
REACT:R-XTR-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Xenopus tropicalis)
REACT:R-MMU-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Mus musculus)
REACT:R-SSC-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Sus scrofa)
RHEA:55157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + glutathione + H(+) + hydrogen sulfide => a quinol + S-sulfanylglutathione
RHEA:40742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb2 + 2 H2O <=> (20S)-ginsenoside C-Y + 2 D-glucose
RHEA:37228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-sorbate + H(+) => (E)-1,3-pentadiene + CO2
REACT:R-GGA-9627104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP3 (Gallus gallus)
REACT:R-CFA-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Canis familiaris)
RHEA:21419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-mannoside alpha-1,6-acetylglucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:mannoside alpha-(1,6) acetylglucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglucosaminyltransferase II activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:mannoside alpha-1,6 acetylglucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1,2-acetylglucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GnTII activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-mannoside alpha(1,6)-acetylglucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-alpha-D-mannoside beta(1,2)-acetylglucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminyltransferase II activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity
GO:0008455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
RHEA:38530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)
REACT:R-DRE-9020277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Danio rerio)
RHEA:69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 <=> H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)
REACT:R-DME-373747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of nephrin by FYN (Drosophila melanogaster)
REACT:R-SPO-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Schizosaccharomyces pombe)
REACT:R-HSA-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)
REACT:R-CFA-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Canis familiaris)
REACT:R-MMU-419001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Mus musculus)
GO:0004738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic acid dehydrogenase activity
GO:0004738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate dehydrogenase activity
GO:0004738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Homo sapiens)
GO:0004738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic dehydrogenase activity
REACT:R-HSA-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Homo sapiens)
REACT:R-MMU-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Mus musculus)
REACT:R-CFA-8950210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 dissociates from Interleukin-27 receptor (Canis familiaris)
REACT:R-HSA-8937820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC,YES1 bind YAP1 (Homo sapiens)
REACT:R-BTA-3247493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO1 (Bos taurus)
RHEA:40360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SSC-6800200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-HGF to form HGF dimer (Sus scrofa)
REACT:R-HSA-8853921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX stimulates p16-INK4A transcription (Homo sapiens)
RHEA:60256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + L-lysyl(4)-[histone H3]
RHEA:40561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+) => dTDP-beta-L-evernosamine + NADPH + O2
REACT:R-DRE-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Danio rerio)
REACT:R-CEL-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Caenorhabditis elegans)
RHEA:27856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-4-hydroxybenzoate + diphosphate => (2E)-geranyl diphosphate + 4-hydroxybenzoate
RHEA:51351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine <=> 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine
RHEA:16593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:16593	skos:altLabel	"flavonol 8-O-methyltransferase"
RHEA:16593	skos:altLabel	"8-hydroxyquercitin 8-O-methyltransferase"
RHEA:16593	skos:prefLabel	"8-hydroxyquercetin 8-O-methyltransferase"
RHEA:16593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-hydroxyquercetin 8-O-methyltransferase"
REACT:R-RNO-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Rattus norvegicus)
RHEA:20943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)
REACT:R-SCE-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Saccharomyces cerevisiae)
REACT:R-DRE-9696268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds effectors (Danio rerio)
RHEA:44091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + heptanoate <=> AMP + diphosphate + heptanoyl-CoA
RHEA:57230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glyoxal
REACT:R-DDI-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Dictyostelium discoideum)
RHEA:33418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bornane-2,6-dione + H2O <=> [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)
REACT:R-BTA-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Bos taurus)
RHEA:41926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-[ACP] + H2O => (3R)-hydroxyoctadecanoyl-[ACP]
RHEA:29470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + K(+)(in) <=> H(+)(in) + K(+)(out)
RHEA:19557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O
RHEA:19557	skos:prefLabel	"steroid 9alpha-monooxygenase"
RHEA:19557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steroid 9alpha-monooxygenase"
RHEA:19557	skos:altLabel	"steroid 9alpha-hydroxylase"
RHEA:40941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+) => 1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH
REACT:R-DME-9650473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 is secreted (Drosophila melanogaster)
RHEA:64389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 A + sn-3-O-phytanylglycerol 1-phosphate => 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
REACT:R-HSA-2997706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 SUMOylates TP53 with SUMO2,3 (Homo sapiens)
RHEA:45707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + NADP(+) <=> (E)-sinapaldehyde + H(+) + NADPH
REACT:R-SSC-6801762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A oligomerize to form a pore complex (Sus scrofa)
REACT:R-DME-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Drosophila melanogaster)
RHEA:36877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA
RHEA:45176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-DME-6786205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Drosophila melanogaster)
GO:0042284	skos:altLabel	"dehydroceramide desaturase"
GO:0042284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-4 sphingolipid desaturase activity
GO:0042284	skos:prefLabel	"sphingolipid 4-desaturase"
GO:0042284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingolipid 4-desaturase"
GO:0042284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid delta-4 desaturase activity
GO:0042284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:67808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine
REACT:R-HSA-174203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-mediated degradation of Emi1 (Homo sapiens)
REACT:R-HSA-5617138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)
REACT:R-MMU-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Mus musculus)
REACT:R-SSC-451634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Sus scrofa)
RHEA:17435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + betaine aldehyde => A + choline
RHEA:18903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl alcohol + CO2 + L-leucine => H(+) + H2O + N-benzyloxycarbonyl-L-leucine
REACT:R-HSA-5690785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds Ub-HCFC1 (Homo sapiens)
REACT:R-HSA-4641246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 autoubiquitinates to promote its internalization (Homo sapiens)
RHEA:22748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate
REACT:R-DRE-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Danio rerio)
GO:0047449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)
GO:0047449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-L-arabinonate dehydratase activity
GO:0047449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-arabinonate dehydratase activity
GO:0047449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity
GO:0008446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose 4,6-dehydratase activity
GO:0008446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose oxidoreductase activity
GO:0008446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-diphosphate-D-mannose oxidoreductase activity
GO:0008446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose 4,6-hydro-lyase activity
GO:0008446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Gmd
GO:0008446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-mannose 4,6-dehydratase activity
GO:0008446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-D-mannose dehydratase activity
GO:0008446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPmannose 4,6-dehydratase activity
GO:0008446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-D-mannose 4,6-dehydratase activity
GO:0008446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)
REACT:R-BTA-5666169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Bos taurus)
RHEA:25218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + serotonin => CoA + H(+) + N-acetylserotonin
GO:0032358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized pyrimidine base DNA binding
GO:0032358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidised pyrimidine DNA binding
GO:0032358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized pyrimidine nucleobase DNA binding
GO:0032358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized pyrimidine DNA binding
REACT:R-BTA-159771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein C to protein C (Bos taurus)
RHEA:15742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) => 2,5-dichlorohydroquinone + H(+) + NADH
GO:0047263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:N-acylsphingosine D-galactosyltransferase activity
GO:0047263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-acylsphingosine galactosyltransferase activity
GO:0047263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP galactose-N-acylsphingosine galactosyltransferase activity
GO:0047263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylsphingosine galactosyltransferase activity
GO:0047263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:N-acylsphingosine D-galactosyltransferase activity
REACT:R-HSA-416985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to synapse (Homo sapiens)
REACT:R-MMU-3323050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNRD2 catalyzes the reduction of TXN2 by NADPH (Mus musculus)
REACT:R-HSA-168400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iE-DAP elicits a NOD1 response (Homo sapiens)
RHEA:45384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:34020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerol + H2O => a fatty acid + glycerol + H(+)
REACT:R-HSA-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Homo sapiens)
RHEA:63158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + taurine => H2O + N-docosanoyl-taurine
REACT:R-BTA-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Bos taurus)
REACT:R-DDI-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Dictyostelium discoideum)
REACT:R-MMU-9749471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
RHEA:43155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(58) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine
REACT:R-CEL-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Caenorhabditis elegans)
REACT:R-HSA-9027274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)
RHEA:49546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + NH4(+) => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O
REACT:R-XTR-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Xenopus tropicalis)
REACT:R-RNO-8981534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin dimer:KIRREL binds FYN (Rattus norvegicus)
REACT:R-SCE-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Saccharomyces cerevisiae)
RHEA:14179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-prunasin + D-glucose => (R)-amygdalin + H2O
REACT:R-BTA-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Bos taurus)
RHEA:25120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)
GO:0047388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl(glutamine synthetase) hydrolase activity
GO:0047388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-[glutamate-ammonia ligase] hydrolase activity
GO:0047388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity
GO:0047388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-glutamate-ammonia ligase hydrolase activity
GO:0047388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GO:0047388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-glutamine-synthetasehydrolase activity
REACT:R-CFA-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)
REACT:R-CFA-8849353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Canis familiaris)
RHEA:69662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kaempferol 3-O-beta-D-glucoside <=> beta-D-glucose + kaempferol
REACT:R-DDI-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Dictyostelium discoideum)
RHEA:16746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + phylloquinone => 2,3-epoxyphylloquinone + A + H2O
RHEA:22843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamine + H2O <=> D-glutamate + NH4(+)
REACT:R-DRE-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Danio rerio)
RHEA:11048	skos:prefLabel	"platelet-activating factor acetyltransferase"
RHEA:11048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"platelet-activating factor acetyltransferase"
RHEA:11048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid
RHEA:11048	skos:altLabel	"PAF acetyltransferase"
RHEA:41159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)
EC:3.2.1.96	skos:altLabel	"di-N-acetylchitobiosyl beta-N-acetylglucosaminidase"
EC:3.2.1.96	skos:altLabel	"endo-beta-N-acetylglucosaminidase"
EC:3.2.1.96	skos:prefLabel	"mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase"
EC:3.2.1.96	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase"
RHEA:31505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate
REACT:R-RNO-877187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates loss of intracellular K+ (Rattus norvegicus)
RHEA:51426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate => a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O
RHEA:28542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)
RHEA:28542	skos:prefLabel	"fluoroacetyl-CoA thioesterase"
RHEA:28542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fluoroacetyl-CoA thioesterase"
REACT:R-BTA-1028816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Bos taurus)
RHEA:43601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosanoyl-[ACP] + H(+) + NADPH => 3R-hydroxyeicosanoyl-[ACP] + NADP(+)
REACT:R-RNO-5635839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3:SUFU dissociates (Rattus norvegicus)
RHEA:39361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH
REACT:R-MMU-201603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of PKC theta (Mus musculus)
REACT:R-CFA-8868659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
REACT:R-XTR-74730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin degradation (Xenopus tropicalis)
REACT:R-DRE-1889955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT dimers transfer GlcA to tetrasaccharide linker (Danio rerio)
REACT:R-CFA-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Canis familiaris)
RHEA:45917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-DME-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Drosophila melanogaster)
REACT:R-GGA-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Gallus gallus)
REACT:R-HSA-9008326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds HDAC4 (Homo sapiens)
REACT:R-HSA-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)
REACT:R-HSA-9011997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter (Homo sapiens)
REACT:R-RNO-9688832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PDCD6IP and SDCBP (Rattus norvegicus)
RHEA:39698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)
REACT:R-BTA-4420117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR2 autophosphorylates (Bos taurus)
RHEA:58176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + 2 diphosphate + NADP(+)
REACT:R-BTA-420233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VIP receptors bind VIP (Bos taurus)
RHEA:37093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA => (8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA
REACT:R-SSC-202331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)
REACT:R-DME-8864569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds TFAP2C (Drosophila melanogaster)
RHEA:66465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O => scalarane-17alpha-19-diol
REACT:R-MMU-6805573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I/type II heterodimers form tetramers (Mus musculus)
REACT:R-DRE-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Danio rerio)
RHEA:18875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + H(+) + NH4(+) + pyruvate => 3-chloro-D-alanine + H2O
REACT:R-DDI-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Dictyostelium discoideum)
REACT:R-HSA-9604831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 (Homo sapiens)
REACT:R-BTA-4090281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Bos taurus)
REACT:R-RNO-5368580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Rattus norvegicus)
REACT:R-SSC-2162227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses (HA)2 (Sus scrofa)
RHEA:43177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:26263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + isopimarate + NADPH => H2O + isopimara-7,15-dienal + NADP(+)
REACT:R-SSC-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Sus scrofa)
REACT:R-CFA-9008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylation (Canis familiaris)
REACT:R-MMU-6786205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Mus musculus)
REACT:R-HSA-2130731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of COPII vesicle (Homo sapiens)
REACT:R-CFA-375342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 36 mediated neuronal gap junction communication (Canis familiaris)
REACT:R-HSA-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Homo sapiens)
RHEA:14224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monomethyl sulfate <=> H(+) + methanol + sulfate
RHEA:43722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juvenile hormone III + S-adenosyl-L-homocysteine => juvenile hormone III carboxylate + S-adenosyl-L-methionine
RHEA:62717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stemphyloxin I => stemphyloxin II
REACT:R-HSA-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Homo sapiens)
REACT:R-SSC-1295604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-RAF dissociates from S111/S120 p-SPRY2 (Sus scrofa)
RHEA:56373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)
RHEA:46590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + H2O + 2 oxidized [adrenodoxin] => calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:33706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine
GO:0030580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinone cofactor methyltransferase activity
REACT:R-SSC-9012315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Sus scrofa)
REACT:R-BTA-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Bos taurus)
REACT:R-BTA-450463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Bos taurus)
GO:0140294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD DNA ADP-ribosyltransferase activity
REACT:R-CFA-3361751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin is replaced by repression complexes at the promoter (Canis familiaris)
REACT:R-SSC-1592398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP8 (Sus scrofa)
REACT:R-BTA-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Bos taurus)
REACT:R-BTA-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
REACT:R-BTA-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Bos taurus)
REACT:R-XTR-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)
REACT:R-GGA-8851933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates GAB1 (Gallus gallus)
REACT:R-GGA-2197697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Gallus gallus)
REACT:R-CFA-9652580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Canis familiaris)
RHEA:70151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate
RHEA:33963	skos:prefLabel	"isopentenyl phosphate kinase"
RHEA:33963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopentenyl phosphate kinase"
RHEA:17805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine
REACT:R-RNO-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Rattus norvegicus)
REACT:R-HSA-9634169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 and NDC1 bind the Nup93 complex (Homo sapiens)
RHEA:48449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine
REACT:R-RNO-9697750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8:FLIP(L) (Rattus norvegicus)
REACT:R-HSA-8981606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin binds oxygen (Homo sapiens)
GO:0008093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal adaptor activity
GO:0008093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal anchor activity
RHEA:23012	skos:prefLabel	"fatty-acid O-methyltransferase"
RHEA:23012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + S-adenosyl-L-methionine = a fatty acid methyl ester + S-adenosyl-L-homocysteine
RHEA:23012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty-acid O-methyltransferase"
GO:0034939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxypyrrole-2-carboxylate tautomerase activity
GO:0032451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylase activity
REACT:R-SSC-5216234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)
REACT:R-MMU-8866327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL translocates from SER lumen to extracellular region (Mus musculus)
GO:0003692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	left-handed Z-DNA binding
GO:0047092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol 7a-hydroxylase activity
GO:0047092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	27-hydroxycholesterol 7alpha-hydroxylase activity
GO:0047092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
GO:0047092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	27-hydroxycholesterol 7-alpha-hydroxylase activity
GO:0047092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol 7-alpha-monooxygenase activity
GO:0047092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	27-hydroxycholesterol 7alpha-monooxygenase activity
REACT:R-CFA-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Canis familiaris)
REACT:R-HSA-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Homo sapiens)
RHEA:58985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + H2O + O2 => acrylate + H(+) + H2O2
REACT:R-RNO-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Rattus norvegicus)
REACT:R-BTA-5675656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA:EDAR binds EDARADD (Bos taurus)
RHEA:66056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan
REACT:R-MMU-5218814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 autophorylates (Mus musculus)
REACT:R-DME-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Drosophila melanogaster)
REACT:R-SCE-69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk1 (Saccharomyces cerevisiae)
RHEA:14107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)
REACT:R-SSC-421007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of Ca impermeable AMPA receptors (Sus scrofa)
REACT:R-GGA-5676917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Gallus gallus)
REACT:R-GGA-451535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of activated ERK2 (Gallus gallus)
RHEA:71532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine(out) => guanine(in)
RHEA:59211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + octadecanoate <=> diphosphate + octadecanoyl-AMP
REACT:R-CFA-936952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Canis familiaris)
RHEA:63663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)
REACT:R-BTA-9625482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated EGFR (Bos taurus)
REACT:R-DME-209244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REL binds to DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)
REACT:R-SSC-211873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)
REACT:R-XTR-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Xenopus tropicalis)
REACT:R-CFA-8944218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VIII (Canis familiaris)
REACT:R-CEL-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Caenorhabditis elegans)
RHEA:42470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopent-4-enoate + salicylate => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O
REACT:R-HSA-8874082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates PTK2 (Homo sapiens)
REACT:R-CEL-2028629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Caenorhabditis elegans)
RHEA:18154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 GTP + H(+) => diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate
RHEA:51610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + 2-oxoglutarate => (R)-2-hydroxyglutarate + pyruvate
RHEA:69628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-HSA-9032073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-phosphorylated FRS2 binds GRB2 (Homo sapiens)
RHEA:37420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:22315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(methylsulfanyl)-D-ribose + ATP <=> ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate
REACT:R-MMU-140686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Mus musculus)
REACT:R-SSC-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Sus scrofa)
RHEA:68897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + H(+) + NADPH => 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)
RHEA:36544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mycothiol S-conjugate => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate
RHEA:40117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + hexanoate => H2O + hexanoyl-CoA
REACT:R-HSA-2022398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Homo sapiens)
RHEA:65201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(acetaldehyde)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O
REACT:R-HSA-8964604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Homo sapiens)
REACT:R-GGA-193705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta phosphorylates IkB causing NF-kB to dissociate (Gallus gallus)
GO:0032767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copper-dependent protein binding
RHEA:12183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + S-adenosyl-L-methionine <=> H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine
RHEA:48895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-glucosamine
EC:3.4.19.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-D-glutamyl-meso-diaminopimelate peptidase"
EC:3.4.19.11	skos:altLabel	"gamma-D-glutamyl-meso-diaminopimelate peptidase I"
EC:3.4.19.11	skos:altLabel	"gamma-D-glutamyl-L-diamino acid endopeptidase I"
EC:3.4.19.11	skos:prefLabel	"gamma-D-glutamyl-meso-diaminopimelate peptidase"
EC:3.4.19.11	skos:altLabel	"endopeptidase I"
GO:0090492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-Dihydroxy-L-tryptophan decarboxylase activity
REACT:R-HSA-2161293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin forms aggregate globules (Homo sapiens)
REACT:R-CEL-418856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 (Caenorhabditis elegans)
REACT:R-SSC-8986985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Sus scrofa)
REACT:R-CFA-8874849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBRF binds CREB3 (Canis familiaris)
RHEA:52801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + ATP + L-isoleucine => AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid
REACT:R-RNO-373716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacting NCK-1 (Rattus norvegicus)
RHEA:31411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
RHEA:26406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) => H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate
RHEA:37335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O = 3-(carbamoylamino)-2-methylpropanoate + H(+)
RHEA:55156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + glutathione + H(+) + hydrogen sulfide = a quinol + S-sulfanylglutathione
RHEA:55156	skos:prefLabel	"eukaryotic sulfide quinone oxidoreductase"
RHEA:55156	skos:altLabel	"SQOR"
RHEA:55156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"eukaryotic sulfide quinone oxidoreductase"
GO:0018688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDT 2,3-dioxygenase activity
REACT:R-DRE-1592314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Danio rerio)
GO:0016614	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on the CH-OH group of donors, other acceptors
GO:0016614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on CH-OH group of donors
REACT:R-CEL-450971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Caenorhabditis elegans)
REACT:R-RNO-1433428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2 is indirectly recruited to p-KIT through SHP2 (Rattus norvegicus)
REACT:R-DDI-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)
REACT:R-SSC-9645394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Sus scrofa)
RHEA:19190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate => (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2
REACT:R-XTR-6807214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Xenopus tropicalis)
REACT:R-DRE-191790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading and methylation of Sm proteins onto SMN Complexes (Danio rerio)
RHEA:43760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]
RHEA:28126	skos:prefLabel	"undecaprenyl-phosphate glucose phosphotransferase"
RHEA:28126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"undecaprenyl-phosphate glucose phosphotransferase"
RHEA:28126	skos:altLabel	"undecaprenylphosphate glucosylphosphate transferase"
RHEA:28126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP
RHEA:29722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(I)alamin(in) <=> cob(I)alamin(out)
REACT:R-MMU-5692437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANG binds F-actin (Mus musculus)
REACT:R-CEL-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Caenorhabditis elegans)
REACT:R-SSC-210881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Tie2/Ang1 complex (Sus scrofa)
REACT:R-XTR-9734535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Xenopus tropicalis)
GO:0106219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc ion sensor activity
RHEA:67286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione => (2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione
REACT:R-RNO-2168923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XVIII endostatin release (Rattus norvegicus)
REACT:R-HSA-6783473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)
REACT:R-BTA-2730840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Bos taurus)
REACT:R-DRE-4724279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Danio rerio)
RHEA:38424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)
EC:2.4.99.1	skos:altLabel	"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase"
EC:2.4.99.1	skos:altLabel	"beta-galactoside alpha-2,6-sialyltransferase"
EC:2.4.99.1	skos:prefLabel	"beta-galactoside alpha-(2,6)-sialyltransferase"
EC:2.4.99.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-galactoside alpha-(2,6)-sialyltransferase"
EC:2.4.99.1	skos:altLabel	"beta-galactosamide alpha-2,6-sialyltransferase"
EC:2.4.99.1	skos:altLabel	"lactosylceramide alpha-2,6-N-sialyltransferase"
REACT:R-MMU-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Mus musculus)
RHEA:44846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-eicosanoyl-(R)-carnitine => (R)-carnitine + eicosanoyl-CoA
REACT:R-MMU-201629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Tau (Mus musculus)
RHEA:44500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)
REACT:R-MMU-451311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca-permeable Kainate receptors (Mus musculus)
REACT:R-GGA-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Gallus gallus)
RHEA:13193	skos:prefLabel	"5-(carboxyamino)imidazole ribonucleotide mutase"
RHEA:13193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-(carboxyamino)imidazole ribonucleotide mutase"
RHEA:13193	skos:altLabel	"N(5)-CAIR mutase"
RHEA:13193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
RHEA:13193	skos:altLabel	"N(5)-carboxyaminoimidazole ribonucleotide mutase"
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-(1,6)-beta-D-glucanase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,6-glucanase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,6-glucan 6-glucanohydrolase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,6-beta-D-glucan glucanohydrolase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,6-beta-glucanase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,6-beta-D-glucanase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-1,6-glucanase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-(1->6)-beta-D-glucanase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,6-glucanase-pustulanase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1->6-glucan hydrolase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan endo-1,6-beta-glucosidase activity
GO:0046557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,6-glucan hydrolase activity
REACT:R-XTR-350901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is organified (Xenopus tropicalis)
RHEA:16970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose
RHEA:25101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UDP <=> ADP + UTP
RHEA:48601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein-PII]-uridylyl-L-tyrosine + H2O => [protein-PII]-L-tyrosine + H(+) + UMP
RHEA:29616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltotriose + beta-maltose => alpha-maltotetraose + beta-D-glucose
GO:0003835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity
GO:0003835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-galactosamide alpha-2,6-sialyltransferase activity
GO:0003835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity
GO:0003835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-galactoside alpha-2,6-sialyltransferase activity
GO:0019150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulokinase activity
GO:0019150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-ribulose 5-phosphotransferase activity
GO:0019150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribulokinase (phosphorylating)
REACT:R-HSA-9698041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 binds the CDKN1A gene (Homo sapiens)
REACT:R-CFA-4641253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 ubiquitinates FZD to promote its downregulation (Canis familiaris)
RHEA:53438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-156808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Danio rerio)
RHEA:33844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoylsphinganine => sphinganine + tetracosanoate
RHEA:12155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4S,5S,6R)-pentachlorocyclohexene <=> (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)
RHEA:43664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + tetracosanoyl-CoA = 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate
REACT:R-HSA-433711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-homodimerization of nectins (Homo sapiens)
REACT:R-CFA-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Canis familiaris)
REACT:R-BTA-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Bos taurus)
REACT:R-DRE-5693742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH hydrolyses AEA to AA and ETA (Danio rerio)
REACT:R-RNO-156723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF20A (MKL2) by phosphorylation (Rattus norvegicus)
REACT:R-HSA-5692315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OX40L binds OX40 (Homo sapiens)
RHEA:36941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA
EC:7.6.2.12	skos:prefLabel	"ABC-type capsular-polysaccharide transporter"
EC:7.6.2.12	skos:altLabel	"capsular-polysaccharide-transporting ATPase"
EC:7.6.2.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type capsular-polysaccharide transporter"
REACT:R-CFA-3451153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits TRRAP/KAT5 HAT components (Canis familiaris)
REACT:R-SSC-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Sus scrofa)
RHEA:30087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2
REACT:R-RNO-158849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phenol can form a sulfate conjugate (Rattus norvegicus)
RHEA:64945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + 2 H2O => dCMP + 2 H(+) + 2 phosphate
RHEA:27750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
REACT:R-XTR-110251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of hypoxanthine by MPG glycosylase (Xenopus tropicalis)
RHEA:41731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-2660816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 (Homo sapiens)
RHEA:39356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)
RHEA:41119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine
RHEA:41827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexanoyl-[ACP] + NADP(+)
REACT:R-HSA-209960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diiodinated tyrosine can be deiodinated (Homo sapiens)
REACT:R-HSA-6784620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) (Homo sapiens)
REACT:R-HSA-9710101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP4, CASP5 cleave GSDMD (Homo sapiens)
RHEA:52110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA
REACT:R-HSA-5654587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS phosphorylates PPTN11 (Homo sapiens)
REACT:R-XTR-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)
RHEA:42108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone
REACT:R-SSC-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Sus scrofa)
REACT:R-SSC-912727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds VAV (Sus scrofa)
RHEA:37128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dioxidophosphate + H2O2 => CO2 + H(+) + phosphonate + succinate
RHEA:25806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal + H2O2 + spermidine => H2O + O2 + spermine
EC:6.1.1.13	skos:altLabel	"D-alanine-activating enzyme"
EC:6.1.1.13	skos:altLabel	"D-alanine-D-alanyl carrier protein ligase"
EC:6.1.1.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-alanine--poly(phosphoribitol) ligase"
EC:6.1.1.13	skos:prefLabel	"D-alanine--poly(phosphoribitol) ligase"
EC:6.1.1.13	skos:altLabel	"D-alanine: membrane acceptor ligase"
EC:6.1.1.13	skos:altLabel	"D-alanine-membrane acceptor ligase"
EC:6.1.1.13	skos:altLabel	"D-alanyl-poly(phosphoribitol) synthetase"
REACT:R-CFA-388855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin-releasing hormone receptor binds PRH (Canis familiaris)
RHEA:51586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonobetainyl-CoA + reduced [electron-transfer flavoprotein] => gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-XTR-6809663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hair keratin fibres (Xenopus tropicalis)
RHEA:25261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2
RHEA:28522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase"
RHEA:28522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate
RHEA:28522	skos:prefLabel	"D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase"
REACT:R-BTA-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Bos taurus)
RHEA:41830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-[ACP] + H2O => (3R)-hydroxyhexanoyl-[ACP]
REACT:R-GGA-195418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-2 associates with VEGFR1 forming complexes on  cell surface (Gallus gallus)
REACT:R-DRE-9749505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC14 binds IKBKB and CHUK (Danio rerio)
REACT:R-GGA-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Gallus gallus)
REACT:R-DME-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Drosophila melanogaster)
REACT:R-MMU-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Mus musculus)
REACT:R-CEL-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Caenorhabditis elegans)
REACT:R-BTA-9604480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFkB complex translocates from the cytosol to the nucleus (Bos taurus)
REACT:R-RNO-165162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TSC2 by PKB (Rattus norvegicus)
RHEA:10755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate <=> [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate
RHEA:15579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose + uracil => H2O + uridine
RHEA:59048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-ornithine/D-lysine decarboxylase"
RHEA:59048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ornithine + H(+) = CO2 + putrescine
RHEA:59048	skos:prefLabel	"D-ornithine/D-lysine decarboxylase"
RHEA:59048	skos:altLabel	"DOKDC"
RHEA:59048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine + H(+) = cadaverine + CO2
REACT:R-GGA-912527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
REACT:R-GGA-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Gallus gallus)
RHEA:16475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxohexanoate + H(+) => cyclohexane-1,3-dione + H2O
REACT:R-DRE-194187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-HSA-168301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation, Polyadenylation and Termination (Homo sapiens)
REACT:R-CFA-5683831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCDC59 binds TTF1 (Canis familiaris)
RHEA:71096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + pregnenolone sulfate(out) => 2 Na(+)(in) + pregnenolone sulfate(in)
REACT:R-GGA-9007283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 and PRC1.6 associate with E2F6.com-1 (Gallus gallus)
REACT:R-CFA-77303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Canis familiaris)
REACT:R-BTA-8864569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds TFAP2C (Bos taurus)
REACT:R-DDI-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Dictyostelium discoideum)
REACT:R-MMU-5638141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Mus musculus)
REACT:R-RNO-8983059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Rattus norvegicus)
RHEA:72906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyrolactone II + dimethylallyl diphosphate <=> butyrolactone I + diphosphate
REACT:R-GGA-2132104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor B binds to the hydrolyzed form of C3 (Gallus gallus)
REACT:R-GGA-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Gallus gallus)
REACT:R-SSC-9759154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM21 ubiquitinates SQSTM1 (Sus scrofa)
GO:0140625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine enkephalin receptor activity
GO:0140625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	met-enkephalin receptor activity
GO:0140625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	opioid growth factor receptor activity
GO:0140625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	metenkefalin receptor activity
RHEA:31321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP => (2R)-3-phosphoglycerate + UDP-alpha-D-glucose
REACT:R-DRE-8848339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA5 hydrolyzes TAG (Danio rerio)
GO:0052822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleate 3-methylguanine glycosidase I
GO:0052822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-3-methylguanine glycosylase activity
GO:0052822	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
GO:0052822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA glycosidase I activity
GO:0052822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methylguanine DNA glycosylase I
REACT:R-MMU-6804741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 forms homo- or heterodimers (Mus musculus)
REACT:R-MMU-9008054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RAPL1 (Mus musculus)
GO:0045480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose oxidase activity
GO:0045480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactose oxidase activity
GO:0045480	skos:prefLabel	"galactose oxidase"
GO:0045480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactose oxidase"
GO:0045480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + O2 = D-galacto-hexodialdose + H2O2
GO:0045480	skos:altLabel	"beta-galactose oxidase"
GO:0045480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactose:oxygen 6-oxidoreductase activity
GO:0045480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-galactose oxidase activity
GO:0033295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyectoine binding
RHEA:46548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine
RHEA:46548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingolipid 10-desaturase"
RHEA:46548	skos:prefLabel	"sphingolipid 10-desaturase"
GO:0070568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanylyltransferase activity
RHEA:49566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate
RHEA:49376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) <=> 3,4-dihydroxyphenylacetate + 2 H(+) + NADH
REACT:R-SSC-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Sus scrofa)
RHEA:20443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine + H(+) => L-cysteine + O2
RHEA:42546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(32) in tRNA => uridine(32) in tRNA
REACT:R-PFA-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Plasmodium falciparum)
REACT:R-SPO-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Schizosaccharomyces pombe)
RHEA:61330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + parthenolide + reduced [NADPH--hemoprotein reductase]
RHEA:43164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-guanine(15) transglycosylase"
RHEA:43164	skos:prefLabel	"tRNA-guanine(15) transglycosylase"
RHEA:43164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine
RHEA:43164	skos:altLabel	"transfer ribonucleic acid guanine(15) transglycosylase"
RHEA:43164	skos:altLabel	"tRNA guanine(15) transglycosidase"
RHEA:39684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)
REACT:R-CEL-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Caenorhabditis elegans)
RHEA:57459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP
REACT:R-BTA-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Bos taurus)
REACT:R-HSA-8852306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Homo sapiens)
REACT:R-DRE-917891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Danio rerio)
RHEA:51909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + H2O => dADP + H(+) + phosphate
REACT:R-GGA-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Gallus gallus)
RHEA:14460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + pentanoyl-CoA <=> 3-propylmalate + CoA + H(+)
RHEA:36217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine
REACT:R-RNO-193727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
RHEA:11196	skos:altLabel	"nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase"
RHEA:11196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase"
RHEA:11196	skos:altLabel	"N(1)-alpha-phosphoribosyltransferase"
RHEA:11196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate
RHEA:11196	skos:prefLabel	"nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase"
REACT:R-HSA-3000074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN2 binds RCbl in the circulation (Homo sapiens)
REACT:R-SSC-451377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IQGAP1 with nephrin (Sus scrofa)
REACT:R-SPO-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Schizosaccharomyces pombe)
REACT:R-HSA-8961863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the DHFR gene promoter (Homo sapiens)
RHEA:51384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + serotonin = CoA + H(+) + N-hexadecanoyl-serotonin
REACT:R-GGA-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Gallus gallus)
RHEA:10644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)
RHEA:10644	skos:altLabel	"2-pyrone-4,6-dicarboxylate hydrolase"
RHEA:10644	skos:prefLabel	"2-pyrone-4,6-dicarboxylate lactonase"
RHEA:10644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-pyrone-4,6-dicarboxylate lactonase"
RHEA:10644	skos:altLabel	"2-pyrone-4,6-dicarboxylate lactonohydrolase"
RHEA:18193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] = (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate
REACT:R-RNO-2426450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins:Nidogens binds collagen type IV networks (Rattus norvegicus)
REACT:R-CFA-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Canis familiaris)
REACT:R-RNO-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Rattus norvegicus)
REACT:R-DRE-210291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Danio rerio)
REACT:R-HSA-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-DRE-8938815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 polyubiquitinates RRAGA (Danio rerio)
GO:0102361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esculetin 4-O-beta-glucosyltransferase activity
RHEA:36903	skos:prefLabel	"tRNA(Phe) [7-(3-amino-3-carboxypropyl)wyosine(37)-O]-methyltransferase"
RHEA:36903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Phe) [7-(3-amino-3-carboxypropyl)wyosine(37)-O]-methyltransferase"
RHEA:36903	skos:altLabel	"tRNA-yW synthesizing enzyme-4"
RHEA:36903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine
RHEA:11813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methanethiol + O2 => formaldehyde + H(+) + H2O2 + hydrogen sulfide
RHEA:45112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol + H(+) + NADPH + O2 = 13-hydroxy-gamma-tocopherol + H2O + NADP(+)
REACT:R-MMU-5682967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 binds DNA DSBs (Mus musculus)
RHEA:18301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NH4(+) + XMP = AMP + diphosphate + GMP + 2 H(+)
REACT:R-GGA-917811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3-like proteins reduce Fe3+ to Fe2+ (Gallus gallus)
REACT:R-SSC-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Sus scrofa)
RHEA:27447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + H(+) + NADPH => NADP(+) + xylitol
REACT:R-HSA-9604738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 dimer binds GRB2 (Homo sapiens)
REACT:R-HSA-9013022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)
REACT:R-BTA-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Bos taurus)
RHEA:22402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyandrostanone + H(+) + NADH => androstan-3alpha,17beta-diol + NAD(+)
REACT:R-BTA-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Bos taurus)
REACT:R-BTA-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Bos taurus)
RHEA:47279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-HSA-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Homo sapiens)
REACT:R-XTR-2018659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Xenopus tropicalis)
REACT:R-DRE-8854222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D3 associates with RAB5 (Danio rerio)
REACT:R-RNO-5099886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binding to FZD promotes PRICKLE1 degradation (Rattus norvegicus)
REACT:R-CEL-1638053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from keratan sulfate (Caenorhabditis elegans)
RHEA:11630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + CO2 => a 2-oxocarboxylate + H(+)
REACT:R-HSA-4088134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates FOXM1 (Homo sapiens)
REACT:R-RNO-5610720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI3 (Rattus norvegicus)
REACT:R-CFA-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Canis familiaris)
GO:0033404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTG codon-amino acid adaptor activity
GO:0033404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine tRNA
GO:0033404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UUG codon-amino acid adaptor activity
GO:0016274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT activity
GO:0016274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine N-methyltransferase activity
REACT:R-BTA-201637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plectin-1 (Bos taurus)
REACT:R-DRE-6781905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZRANB1 binds APC (Danio rerio)
RHEA:54063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (2Z,6E)-hedycaryol + diphosphate
REACT:R-SSC-388808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-2 monomer (Sus scrofa)
REACT:R-SSC-420980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Sus scrofa)
REACT:R-BTA-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
REACT:R-CFA-77301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Canis familiaris)
RHEA:54936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-[ACP] + H(+) + NADH = decanoyl-[ACP] + NAD(+)
REACT:R-MMU-937044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 (Mus musculus)
REACT:R-RNO-5654615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:pFRS binds GRB2:SOS1 (Rattus norvegicus)
REACT:R-GGA-4084980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Gallus gallus)
REACT:R-BTA-163809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)
RHEA:41912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+)
RHEA:19070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-lactoylglutathione => glutathione + methylglyoxal
RHEA:10850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an [alpha-factor](out) + H(+) + phosphate => an [alpha-factor](in) + ATP + H2O
REACT:R-CEL-9648949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A antagonists bind HTR3A pentamer (Caenorhabditis elegans)
RHEA:37178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:52390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-D-threonate + ADP + H(+) => ATP + D-threonate
REACT:R-HSA-3782655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC10 deacetylates histone (Homo sapiens)
REACT:R-RNO-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)
GO:0047345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphoribose phosphorylase activity
GO:0047345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose-5-phosphate adenylyltransferase activity
GO:0047345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP:D-ribose-5-phosphate adenylyltransferase activity
GO:0047345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP:ribose-5-phosphate adenylyltransferase activity
GO:0047345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP ribose phosphorylase activity
GO:0047345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-ribose phosphorylase activity
RHEA:45065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoylethanolamine => ethanolamine + hexadecanoate
REACT:R-SCE-9668335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds LEMD2 (Saccharomyces cerevisiae)
REACT:R-HSA-5632759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the SCO2 gene (Homo sapiens)
REACT:R-GGA-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Gallus gallus)
REACT:R-XTR-5218854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y420-FYN is phosphorylated on S21 (Xenopus tropicalis)
RHEA:13101	skos:altLabel	"urocanase"
RHEA:13101	skos:altLabel	"imidazolonepropionate hydrolase"
RHEA:13101	skos:prefLabel	"urocanate hydratase"
RHEA:13101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propanoate = H2O + trans-urocanate
RHEA:13101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"urocanate hydratase"
REACT:R-CFA-388808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-2 monomer (Canis familiaris)
RHEA:42931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:21840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
REACT:R-BTA-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Bos taurus)
RHEA:69426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + formyl-CoA => 2-hydroxyisobutanoyl-CoA
REACT:R-CFA-1564169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VIII degradation by MMP1 (Canis familiaris)
REACT:R-SSC-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Sus scrofa)
REACT:R-SSC-399933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sema3A binds Nrp-1 bound to PlexinA (Sus scrofa)
REACT:R-CFA-1306963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Canis familiaris)
REACT:R-CEL-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Caenorhabditis elegans)
RHEA:65664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + 4 Na(+)(out) = citrate(in) + 4 Na(+)(in)
RHEA:16090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphoethanolamine => ethanolamine + phosphate
GO:0102266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-dihydrouridine20a synthase activity
REACT:R-CFA-1679098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Canis familiaris)
RHEA:34463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycopalyl diphosphate = cis-abienol + diphosphate
RHEA:34463	skos:prefLabel	"cis-abienol synthase"
RHEA:34463	skos:altLabel	"Z-abienol synthase"
RHEA:34463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-abienol synthase"
REACT:R-CEL-193711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
REACT:R-DRE-5666104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Danio rerio)
REACT:R-HSA-4755524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1I2 with SUMO3 (Homo sapiens)
RHEA:40143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)
REACT:R-XTR-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Xenopus tropicalis)
REACT:R-CFA-9731228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)
RHEA:52594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH => deoxycholoyl-CoA + NAD(+)
RHEA:52473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-RNO-6800794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 associates with CRADD (Rattus norvegicus)
REACT:R-HSA-1855197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)
REACT:R-MMU-4719447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO1 (Mus musculus)
REACT:R-SSC-6788611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYKK phosphorylates 5HLYS (Sus scrofa)
REACT:R-SSC-8937613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHBP binds CRH (Sus scrofa)
REACT:R-DRE-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Danio rerio)
RHEA:30885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate + 3 H(+) + NADH => D-glucurono-3,6-lactone + 2 H2O + NAD(+)
RHEA:20399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L,L-cystathionine + succinate => L-cysteine + O-succinyl-L-homoserine
REACT:R-HSA-2855054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-2 binds to molecular patterns on the target cell surface  (Homo sapiens)
RHEA:57311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + N(5)-phospho-L-glutamine <=> diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine
EC:4.1.1.94	skos:prefLabel	"ethylmalonyl-CoA decarboxylase"
EC:4.1.1.94	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethylmalonyl-CoA decarboxylase"
REACT:R-CEL-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)
REACT:R-HSA-5663232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL1 binds RAC1:GTP (Homo sapiens)
RHEA:16554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]
REACT:R-XTR-193995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 18-hydroxylates CORST to 18HCORST (Xenopus tropicalis)
REACT:R-MMU-373339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Mus musculus)
RHEA:55180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylnonanoyl-CoA + O2 = 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate
RHEA:60477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + GTP => 3',3',3'-cAAG + 3 diphosphate
RHEA:45095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octanoylsphing-4-enine <=> octanoate + sphing-4-enine
GO:0061761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	latrophilin binding
GO:0061761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-latrotoxin receptor binding
GO:0061761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lasso receptor binding
RHEA:72192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:20071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phenylacetonitrile => (Z)-phenylacetaldehyde oxime
RHEA:17956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 <=> (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde
RHEA:45627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine <=> AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]
REACT:R-HSA-9027302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Homo sapiens)
REACT:R-SCE-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Saccharomyces cerevisiae)
REACT:R-MMU-75079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC C complex (Mus musculus)
GO:0102853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity
REACT:R-CFA-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Canis familiaris)
RHEA:39802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH
RHEA:22454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n H(+) + (n+1) phosphate => [phosphate](n+1) + n H2O
REACT:R-MMU-8964605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Mus musculus)
RHEA:42972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine
RHEA:17112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)
RHEA:37531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
RHEA:40267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH
REACT:R-XTR-9718360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide agonists (Xenopus tropicalis)
GO:0005148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prolactin receptor binding
GO:0005148	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	prolactin receptor ligand
GO:0005148	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	prolactin
RHEA:10197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O
RHEA:58344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->3)-O-lithocholate + H2O = D-glucose + lithocholate
REACT:R-CFA-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Canis familiaris)
RHEA:45958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA(out) => (9Z)-octadecenoyl-CoA(in)
REACT:R-BTA-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Bos taurus)
RHEA:28818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate(in) + H(+)(out) <=> 4-hydroxybenzoate(out) + H(+)(in)
REACT:R-CFA-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Canis familiaris)
REACT:R-CEL-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Caenorhabditis elegans)
RHEA:21371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + urate <=> 5-hydroxyisourate + H2O2
RHEA:58167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 2 H2O <=> 7-epi-ent-eudesmane-5,11-diol + diphosphate
REACT:R-DRE-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Danio rerio)
RHEA:55722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]
RHEA:60098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4alpha-methylzymosterol + CO2 + NADPH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)
REACT:R-CEL-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Caenorhabditis elegans)
REACT:R-DDI-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Dictyostelium discoideum)
REACT:R-CFA-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Canis familiaris)
REACT:R-DRE-2514831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP14 (Danio rerio)
REACT:R-DRE-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Danio rerio)
RHEA:21077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + 2-oxoglutarate + O2 => CO2 + succinate + uridine
REACT:R-SCE-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Saccharomyces cerevisiae)
REACT:R-DRE-190427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1b (Danio rerio)
RHEA:48238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+) => 2 2-acetylphloroglucinol
RHEA:47776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:47289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-163798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein Z to protein Z (Danio rerio)
RHEA:68331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + H2O <=> (R)-pantetheine + phosphate
GO:0050487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphoacetaldehyde acetyltransferase activity
GO:0050487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfoacetaldehyde acetyltransferase activity
GO:0050487	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)
GO:0019142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-hydroxyglutarate synthase activity
GO:0019142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity
GO:0019142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyglutarate synthase activity
GO:0019142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxyglutaric synthetase activity
GO:0019142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate synthase activity
GO:0019142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxyglutaratic synthetase activity
GO:0019142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)
REACT:R-BTA-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)
REACT:R-MMU-194518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoA is activated by nucleotide exchange and inhibits axonal growth (Mus musculus)
RHEA:38336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb1 + 2 H2O => (20S)-ginsenoside Rg3 + 2 D-glucose
GO:0035274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP binding
GO:0035274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphenyl phthalate binding
REACT:R-DDI-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Dictyostelium discoideum)
REACT:R-DME-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Drosophila melanogaster)
REACT:R-SSC-187020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of pro-beta-NGF is processed to mature beta-NGF (Sus scrofa)
RHEA:20300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anilide + H2O <=> a carboxylate + aniline + H(+)
RHEA:63408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-chloropyridine-2,3,5-triol + FADH2 + O2 = 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O
REACT:R-SSC-391155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRPA binds SFTPA oligomer, SFTPD oligomer (Sus scrofa)
RHEA:23687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-2465934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL translocates from Muller cells to cone photoreceptor cells (Gallus gallus)
RHEA:10461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin A1 => prostaglandin C1
RHEA:47725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione => 5-oxo-L-proline + L-cysteinylglycine
REACT:R-HSA-6794352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs binds CASK tripartite complex (Homo sapiens)
RHEA:63434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O
RHEA:38607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate
REACT:R-DME-211207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fragments of DFF45 dissociate from  DFF40 (Drosophila melanogaster)
REACT:R-HSA-9667638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBEA translocates to the nucleus (Homo sapiens)
REACT:R-PFA-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Plasmodium falciparum)
REACT:R-SSC-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Sus scrofa)
REACT:R-BTA-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Bos taurus)
RHEA:38936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-CFA-5685319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex formation (Canis familiaris)
RHEA:19167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose
REACT:R-DRE-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Danio rerio)
RHEA:23051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxybutanoate + 2-oxoglutarate <=> (R)-2-hydroxyglutarate + acetoacetate
REACT:R-CEL-5099886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binding to FZD promotes PRICKLE1 degradation (Caenorhabditis elegans)
REACT:R-HSA-8952101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p14-ARF transcription is stimulated by RUNX proteins (Homo sapiens)
RHEA:68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyindolin-2-one + NADP(+) => H(+) + isatin + NADPH
REACT:R-RNO-201628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at DSVD (85) (Rattus norvegicus)
REACT:R-CEL-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Caenorhabditis elegans)
RHEA:50606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] => acetyl-CoA + N-terminal L-methionyl-[transmembrane protein]
REACT:R-HSA-5658231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs stimulate RAS GTPase activity (Homo sapiens)
REACT:R-RNO-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Rattus norvegicus)
GO:0030371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation repressor activity
REACT:R-XTR-976743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates plasma Factor H-bound C3b (Xenopus tropicalis)
REACT:R-CFA-9708430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 (CRM1) binds to BACH1:Hemes (Canis familiaris)
REACT:R-SCE-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Saccharomyces cerevisiae)
REACT:R-CFA-159046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Canis familiaris)
REACT:R-BTA-1307963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Bos taurus)
GO:0018622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorophenylacetate 3,4-dioxygenase activity
GO:0018622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)
REACT:R-BTA-9646685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggresome dissociates from dynein and microtubule (Bos taurus)
GO:0046583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation efflux transmembrane transporter activity
GO:0046583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation efflux permease activity
REACT:R-BTA-4084982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Bos taurus)
REACT:R-SCE-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Saccharomyces cerevisiae)
REACT:R-DRE-211959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A43 6b-hydroxylates TEST (Danio rerio)
REACT:R-DDI-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Dictyostelium discoideum)
RHEA:64879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP <=> H(+) + phosphate + UMP
REACT:R-RNO-2562526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates OPTN (Rattus norvegicus)
RHEA:16263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-succinyl-L-lysyl-[protein] => L-lysyl-[protein] + succinyl-CoA
RHEA:18762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)
RHEA:63109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxy-ilicicolin A epoxide => ascofuranol
REACT:R-DRE-70859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Danio rerio)
RHEA:23995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA
REACT:R-MMU-9710106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE cleaves GSDMD (Mus musculus)
REACT:R-RNO-2031355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
RHEA:43069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-3296244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUCNR1 binds SUCCA (Homo sapiens)
REACT:R-MMU-9015122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors bind Va:Xa (Mus musculus)
REACT:R-MMU-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Mus musculus)
REACT:R-HSA-6788912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)
REACT:R-GGA-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Gallus gallus)
RHEA:67812	skos:prefLabel	"acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase"
RHEA:67812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]
RHEA:67812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase"
RHEA:67812	skos:altLabel	"acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase"
RHEA:67812	skos:altLabel	"UDP-N-acetylglucosamine acyltransferase"
RHEA:39330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O
REACT:R-CFA-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Canis familiaris)
REACT:R-SCE-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)
REACT:R-SSC-69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk1 (Sus scrofa)
RHEA:55391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2
RHEA:55062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]
GO:0034901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endosulfan hydroxyether dehydrogenase activity
REACT:R-SSC-6799959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP3,4 binds bacterial peptidoglycan (Sus scrofa)
GO:0004441	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol polyphosphate 1-phosphatase activity
GO:0004441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,4-bisphosphate 1-phosphatase activity
GO:0004441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol-polyphosphate 1-phosphatase activity
GO:0004441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity
REACT:R-RNO-5340195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4 binds DCA, CDCA, LCHA (Rattus norvegicus)
GO:0000995	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcription factor activity, core RNA polymerase III binding
GO:0000995	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase III transcription factor activity, sequence-specific DNA binding
GO:0000995	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	core RNA polymerase III binding transcription factor activity
GO:0000995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III general transcription initiation factor activity
GO:0000995	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sequence-specific DNA binding RNA polymerase III transcription factor activity
GO:0000995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III general initiation factor activity
REACT:R-SSC-2028284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Sus scrofa)
RHEA:42504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-acetyl-L-lysine = 6-acetamido-2-oxohexanoate + L-glutamate
RHEA:51745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)
RHEA:64217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-L-lyxonate + H(+) => CO2 + L-lyxonate
RHEA:50668	skos:altLabel	"guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase"
RHEA:50668	skos:altLabel	"beta-galactoside alpha(1->2)fucosyltransferase"
RHEA:50668	skos:altLabel	"guanosine diphosphofucose-galactoside 2-L-fucosyltransferase"
RHEA:50668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)
RHEA:50668	skos:altLabel	"alpha-(1->2)-L-fucosyltransferase"
RHEA:50668	skos:altLabel	"alpha-2-fucosyltransferase"
RHEA:50668	skos:altLabel	"blood-group substance H-dependent fucosyltransferase"
RHEA:50668	skos:altLabel	"guanosine diphospho-L-fucose-lactose fucosyltransferase"
RHEA:50668	skos:altLabel	"guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase"
RHEA:50668	skos:altLabel	"guanosine diphosphofucose-lactose fucosyltransferase"
RHEA:50668	skos:altLabel	"alpha-2-L-fucosyltransferase"
RHEA:50668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"type 2 galactoside alpha-(1,2)-fucosyltransferase"
RHEA:50668	skos:altLabel	"blood group H alpha-2-fucosyltransferase"
RHEA:50668	skos:prefLabel	"type 2 galactoside alpha-(1,2)-fucosyltransferase"
RHEA:50668	skos:altLabel	"guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase"
RHEA:50668	skos:altLabel	"guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase"
RHEA:50668	skos:altLabel	"H-gene-encoded beta-galactoside alpha(1->2)fucosyltransferase"
RHEA:50668	skos:altLabel	"GDP fucose-lactose fucosyltransferase"
RHEA:15470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
REACT:R-CFA-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Canis familiaris)
REACT:R-DRE-9654523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP bind PDE6D on KRAS4B (Danio rerio)
RHEA:57401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-acetylpapaveroxine + H2O => acetate + H(+) + narcotine hemiacetal
RHEA:34539	skos:prefLabel	"tellurite methyltransferase"
RHEA:34539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tellurite methyltransferase"
RHEA:34539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + tellurite = methanetellurite + S-adenosyl-L-homocysteine
RHEA:28070	skos:prefLabel	"heme o synthase"
RHEA:28070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heme o synthase"
RHEA:28070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o
RHEA:18147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-fructose 1-phosphate + H(+) => ATP + beta-D-fructose
REACT:R-SSC-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Sus scrofa)
REACT:R-XTR-2022383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)
REACT:R-SSC-2730847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP2 by PLCG (Sus scrofa)
RHEA:17663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + phosphate + succinyl-CoA => ATP + CoA + succinate
REACT:R-HSA-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Homo sapiens)
REACT:R-DME-9008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 phosphorylates RUNX2 (Drosophila melanogaster)
REACT:R-CFA-209055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
RHEA:47058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2
REACT:R-SSC-6804741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 forms homo- or heterodimers (Sus scrofa)
REACT:R-GGA-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Gallus gallus)
RHEA:63529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + H2O2 => [thioredoxin]-disulfide + 2 H2O
RHEA:45188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-446694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 phosphorylates IRAK1 (Canis familiaris)
RHEA:11746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphate + thiamine diphosphate => H2O + thiamine triphosphate
GO:0008779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity
GO:0008779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity
GO:0008779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
GO:0008779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-ACP-phospholipid O-acyltransferase activity
GO:0008779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity
RHEA:20660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorophenylacetonitrile + 2 H2O <=> 4-chlorophenylacetate + NH4(+)
RHEA:39695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)
RHEA:64154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate
REACT:R-BTA-5693373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Bos taurus)
REACT:R-XTR-420584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin 3 trans heterodimer interaction (Xenopus tropicalis)
RHEA:43881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA => (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate
REACT:R-HSA-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Homo sapiens)
RHEA:48780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-erythrulose = ADP + H(+) + L-erythrulose 1-phosphate
RHEA:48780	skos:prefLabel	"L-erythrulose 1-kinase"
RHEA:48780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-erythrulose 1-kinase"
RHEA:67782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-MMU-5357928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLIP3 and CYLD bind TNF signaling complex (Mus musculus)
RHEA:18892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + UDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + UDP
REACT:R-MMU-2214330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of collagen VII NC2 region by BMP1 (Mus musculus)
REACT:R-DRE-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Danio rerio)
GO:0102874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity
REACT:R-BTA-2426259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Bos taurus)
RHEA:38169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanyl hexadecanoate => hexadecan-1-ol + hexadecanoyl-CoA
RHEA:12659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-methylacyl-CoA => a (2S)-2-methylacyl-CoA
REACT:R-SSC-9607304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Sus scrofa)
GO:0001729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:ceramide 1-phosphotransferase activity
GO:0001729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERK phosphorylates CERA to form C1P (Homo sapiens)
GO:0001729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylsphingosine kinase activity
GO:0001729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide kinase activity
RHEA:70391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + eicosanoyl-CoA = CoA + H(+) + N-eicosanoyl-3-oxosphinganine
RHEA:49851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)
REACT:R-DRE-211929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C19 5-hydroxylates omeprazole (Danio rerio)
REACT:R-HSA-9620837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNG2 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)
REACT:R-BTA-2230983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP1:Hemopexin:heme is endocytosed (Bos taurus)
REACT:R-DRE-5638016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2:ARL3:GDP:UNC119B dissociates (Danio rerio)
REACT:R-SSC-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Sus scrofa)
REACT:R-XTR-9008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37, IL37(?-218) translocates from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-BTA-8940070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NAD+ (Bos taurus)
RHEA:49796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-glycine + H2O = a fatty acid + glycine
REACT:R-DRE-1678921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length TLR3/7/8/9 binds to UNC93B1 (Danio rerio)
REACT:R-MMU-3266566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Mus musculus)
REACT:R-GGA-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Gallus gallus)
RHEA:56421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[D-alanyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]
RHEA:48415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside IV3GalNAc-Gb4Cer + H2O <=> globoside Gb4Cer + N-acetyl-alpha-D-galactosamine
RHEA:23391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hygromycin B <=> 7''-O-phosphohygromycin B + ADP + H(+)
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid monophosphatase activity
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid phosphomonoesterase activity
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphomonoesterase activity
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid nucleoside diphosphate phosphatase activity
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid phosphomonoester hydrolase activity
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orthophosphoric-monoester phosphohydrolase (acid optimum)
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycerophosphatase activity
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphate-monoester phosphohydrolase (acid optimum)
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uteroferrin
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTRAP hydrolyzes FMN to RIB (Homo sapiens)
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid phosphohydrolase activity
GO:0003993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acid phosphatase activity
GO:0033722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate-semialdehyde dehydrogenase activity
GO:0033722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonic semialdehyde dehydrogenase activity
GO:0033722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxopropanoate:NAD(P)+ oxidoreductase activity
RHEA:25754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:49406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + D-mannose => beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate
REACT:R-DME-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)
REACT:R-CEL-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
REACT:R-DRE-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Danio rerio)
REACT:R-XTR-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Xenopus tropicalis)
GO:0030283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone dehydrogenase [NAD(P)] activity
GO:0030283	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-hydroxy steroid dehydrogenase
GO:0030283	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3beta-hydroxy steroid dehydrogenase
GO:0030283	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
GO:0030283	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3(or 17)beta-hydroxysteroid dehydrogenase activity
GO:0030283	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3beta-hydroxysteroid dehydrogenase
GO:0030283	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	17beta-hydroxy steroid dehydrogenase
RHEA:46631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH <=> androst-5-en-3beta,17beta-diol + NADP(+)
REACT:R-SSC-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Sus scrofa)
REACT:R-HSA-1799330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SRP receptor binds the SRP:nascent peptide:ribosome complex (Homo sapiens)
RHEA:17375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-capsanthin => all-trans-antheraxanthin
RHEA:35323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH
RHEA:35323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH
RHEA:35323	skos:prefLabel	"4-hydroxy-tetrahydrodipicolinate reductase"
RHEA:35323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-tetrahydrodipicolinate reductase"
RHEA:35323	skos:altLabel	"dihydrodipicolinate reductase"
REACT:R-XTR-6804724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates phosphorylated MDM4 (Xenopus tropicalis)
RHEA:14977	skos:altLabel	"3-carboxy-cis,cis-muconate lactonizing enzyme"
RHEA:14977	skos:prefLabel	"carboxy-cis,cis-muconate cyclase"
RHEA:14977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxy-cis,cis-muconate cyclase"
RHEA:14977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate
RHEA:14977	skos:altLabel	"3-carboxymuconate cyclase"
RHEA:48097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine
REACT:R-XTR-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Xenopus tropicalis)
REACT:R-HSA-9759137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 and MAFK bind the HMOX1 gene (Homo sapiens)
RHEA:12756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NADP(+) <=> dihydroxyacetone + H(+) + NADPH
REACT:R-DRE-2065539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:Importin beta-1 dissociates (Danio rerio)
REACT:R-RNO-9604480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFkB complex translocates from the cytosol to the nucleus (Rattus norvegicus)
REACT:R-GGA-879934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SHC1 is mediated by Y593 of the common beta chain (Gallus gallus)
REACT:R-BTA-4085087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Bos taurus)
REACT:R-DME-391940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 and EP4 receptors can bind PGE2 (Drosophila melanogaster)
RHEA:19611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine
REACT:R-DME-8950778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dimerizes (Drosophila melanogaster)
RHEA:22070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)
RHEA:59179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + L-serine <=> AMP + H(+) + O-phospho-L-serine
REACT:R-RNO-430158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds VAV (Rattus norvegicus)
REACT:R-HSA-5655351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 mutants bind FRS2 (Homo sapiens)
REACT:R-HSA-191830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP nuclear import and release (Homo sapiens)
REACT:R-DRE-5687484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Danio rerio)
REACT:R-DME-141423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)
REACT:R-XTR-374723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nociceptin receptor binds to nociceptin (Xenopus tropicalis)
RHEA:30117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoate + H(+) + holo-[ACP] => decanoyl-[ACP] + H2O
RHEA:23223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoate + ATP + CoA <=> 4-chlorobenzoyl-CoA + AMP + diphosphate
REACT:R-MMU-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Mus musculus)
RHEA:69119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + glycine
RHEA:20499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-2-arylethylamine => 2-arylethylamine + acetyl-CoA
REACT:R-CFA-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Canis familiaris)
REACT:R-RNO-8983374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Rattus norvegicus)
REACT:R-BTA-9026911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Bos taurus)
REACT:R-DME-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Drosophila melanogaster)
GO:0033854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-prephenate aminotransferase activity
GO:0033854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:prephenate aminotransferase activity
GO:0033854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAT
GO:0033854	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	prephenate transaminase activity
GO:0033854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arogenate:2-oxoglutarate aminotransferase activity
RHEA:14278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + H2O + NAD(+) => (S)-lactate + 2 H(+) + NADH
RHEA:43260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
REACT:R-DRE-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Danio rerio)
RHEA:25176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-methyl-L-arginine <=> L-citrulline + methylamine
RHEA:25606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O => 2-(3-methylsulfanyl)propylmalate + CoA + H(+)
REACT:R-DME-390116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho FT reduces D accumulation at the plasma membrane (Drosophila melanogaster)
REACT:R-SSC-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Sus scrofa)
RHEA:60837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-adenosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate
RHEA:35960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tryprostatin B => demethoxyfumitremorgin C + 2 H2O + NADP(+)
REACT:R-HSA-8877879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and FOXP3 bind the RSPO3 gene promoter (Homo sapiens)
REACT:R-RNO-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Rattus norvegicus)
REACT:R-HSA-9667952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 is deacetylated by SIRT2 (Homo sapiens)
REACT:R-HSA-2220985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)
RHEA:58799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 7-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA
REACT:R-RNO-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)
RHEA:23237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-L-glutamate 5-O-methyl ester + H2O => H(+) + L-glutamyl-[protein] + methanol
RHEA:38254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + octadecanoyl-CoA <=> CoA + hexadecanyl octadecanoate
RHEA:39146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH
REACT:R-BTA-6784959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPHL hydrolyses VACV to ACV (Bos taurus)
REACT:R-DRE-176175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Stalling of DNA replication fork and RPA binding (Danio rerio)
REACT:R-HSA-193636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with the NOGO receptor (Homo sapiens)
RHEA:56440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-HSA-5358545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) (Homo sapiens)
RHEA:18939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + L-homoserine lactone => an N-acyl-L-homoserine lactone + H2O
RHEA:68524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = beta-bisabolene + diphosphate
REACT:R-BTA-5654587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS phosphorylates PPTN11 (Bos taurus)
REACT:R-MMU-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Mus musculus)
RHEA:14881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) = asparagusate + H(+) + NADH
RHEA:14881	skos:prefLabel	"asparagusate reductase"
RHEA:14881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"asparagusate reductase"
RHEA:14881	skos:altLabel	"asparagusate reductase (NADH)"
RHEA:14881	skos:altLabel	"asparagusate dehydrogenase"
RHEA:14881	skos:altLabel	"asparagusic dehydrogenase"
RHEA:32154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate <=> (12E)-9alpha-labda-8(17),12,14-triene + diphosphate
REACT:R-BTA-8949659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Bos taurus)
REACT:R-SSC-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Sus scrofa)
REACT:R-DME-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Drosophila melanogaster)
REACT:R-HSA-1470011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Downregulation of c-Kit signaling by SOCS6 (Homo sapiens)
REACT:R-DME-1793186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Drosophila melanogaster)
REACT:R-CFA-9018594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds LBR (Canis familiaris)
REACT:R-GGA-8941234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Gallus gallus)
REACT:R-BTA-390281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Bos taurus)
RHEA:14237	skos:prefLabel	"deoxysarpagine hydroxylase"
RHEA:14237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxysarpagine hydroxylase"
RHEA:14237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine
RHEA:14237	skos:altLabel	"DOSH"
REACT:R-CFA-8940070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NAD+ (Canis familiaris)
REACT:R-MMU-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Mus musculus)
REACT:R-SSC-158795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Sus scrofa)
RHEA:40637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O
RHEA:63520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopropylphenol + H(+) + NADH + O2 = 3-isopropylcatechol + H2O + NAD(+)
RHEA:30592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + tyramine => (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)
REACT:R-SCE-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Saccharomyces cerevisiae)
REACT:R-DME-1222491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoferrin scavenges iron ions (Drosophila melanogaster)
REACT:R-XTR-5666001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Profilin:G-actin binds MKL1 (Xenopus tropicalis)
REACT:R-GGA-2132269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of classical C5 convertase (Gallus gallus)
REACT:R-XTR-8851929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Xenopus tropicalis)
REACT:R-HSA-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)
REACT:R-CFA-8982617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB:O2 dissociates (Canis familiaris)
REACT:R-XTR-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Xenopus tropicalis)
RHEA:44856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-octadecenoyl-(R)-carnitine
RHEA:53992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-HSA-449872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde [cytosolic] => acetaldehyde [mitochondrial] (Homo sapiens)
RHEA:70644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-proline(out) + H(+)(out) => D-proline(in) + H(+)(in)
REACT:R-DRE-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Danio rerio)
RHEA:68906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanal + AMP + diphosphate + NADP(+) => 3-phenylpropanoate + ATP + H(+) + NADPH
REACT:R-XTR-6800315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 binds MST1R (Xenopus tropicalis)
REACT:R-MMU-450434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Mus musculus)
RHEA:38199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5625426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde IFT (Homo sapiens)
RHEA:52069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)
REACT:R-BTA-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Bos taurus)
REACT:R-HSA-1470073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxynitrite enters the bacterium (Homo sapiens)
REACT:R-CEL-8938853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 binds RUNX1 (Caenorhabditis elegans)
REACT:R-CEL-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)
REACT:R-BTA-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)
REACT:R-DRE-2404199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:IGF1R autophosphorylates (Danio rerio)
REACT:R-DRE-5661120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Danio rerio)
REACT:R-HSA-9018594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds LBR (Homo sapiens)
RHEA:31319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + UDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP
RHEA:31319	skos:altLabel	"GPG synthase"
RHEA:31319	skos:prefLabel	"glucosyl-3-phosphoglycerate synthase"
RHEA:31319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosyl-3-phosphoglycerate synthase"
RHEA:31319	skos:altLabel	"glucosylphosphoglycerate synthase"
REACT:R-MMU-8869580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEK binds TFAP2A homodimers (Mus musculus)
REACT:R-RNO-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Rattus norvegicus)
REACT:R-RNO-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Rattus norvegicus)
RHEA:13275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol
REACT:R-CFA-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Canis familiaris)
RHEA:39708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA(out) => a long-chain fatty acyl-CoA(in)
GO:0047123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinoline-4-carboxylic acid 2-oxidoreductase activity
GO:0047123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinoline-4-carboxylate 2-oxidoreductase activity
GO:0047123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)
REACT:R-CFA-8944246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXI (Canis familiaris)
REACT:R-SSC-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)
REACT:R-HSA-9029149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 (Homo sapiens)
RHEA:40154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
REACT:R-HSA-9726848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RHOU (Homo sapiens)
REACT:R-DME-209859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decarboxylation of 5-hydroxytryptophan forms serotonin (Drosophila melanogaster)
RHEA:48073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + H2O => ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate
RHEA:35876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:69742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylsuccinate + succinyl-CoA <=> 3-phenylsuccinyl-CoA + succinate
RHEA:56552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[rhodopsin] = ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]
RHEA:37338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O <=> 3-(carbamoylamino)-2-methylpropanoate + H(+)
REACT:R-CFA-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Canis familiaris)
GO:0005253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anion channel activity
GO:0005253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-6 passively transports anions out of vesicles (Homo sapiens)
GO:0005253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-6 passively transports anions into vesicles (Homo sapiens)
GO:0005253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	non-selective anion channel activity
RHEA:72714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cathenamine + H(+) <=> 4,21-dehydrogeissoschizine
REACT:R-HSA-983266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins bind microtubules (Homo sapiens)
RHEA:48516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)
RHEA:72961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate(in) + 2 Na(+)(in) => (R)-3-hydroxybutanoate(out) + 2 Na(+)(out)
REACT:R-SSC-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Sus scrofa)
RHEA:25426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + guanine => diphosphate + GMP
RHEA:47726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline + L-cysteinylglycine => glutathione
REACT:R-SPO-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Schizosaccharomyces pombe)
RHEA:34561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11-oxopentalenate + H(+) + NADH => 1-deoxy-11beta-hydroxypentalenate + NAD(+)
RHEA:16196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)
REACT:R-DDI-6807875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Dictyostelium discoideum)
REACT:R-SCE-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Saccharomyces cerevisiae)
RHEA:69109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine
REACT:R-DME-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Drosophila melanogaster)
REACT:R-XTR-163798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein Z to protein Z (Xenopus tropicalis)
REACT:R-RNO-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Rattus norvegicus)
RHEA:17257	skos:prefLabel	"vinorine hydroxylase"
RHEA:17257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vinorine hydroxylase"
RHEA:17257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + vinorine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine
GO:0047232	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase
GO:0047232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0047232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity
REACT:R-HSA-9760125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2-dependent GCLM gene expression (Homo sapiens)
REACT:R-DRE-3323013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)
REACT:R-MMU-8848975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS1 (Mus musculus)
REACT:R-XTR-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Xenopus tropicalis)
REACT:R-BTA-429798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Bos taurus)
REACT:R-BTA-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
REACT:R-CFA-2197697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)
REACT:R-DME-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Drosophila melanogaster)
REACT:R-RNO-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Rattus norvegicus)
RHEA:71518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine(out) <=> hypoxanthine(in)
RHEA:31509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine
REACT:R-CFA-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Canis familiaris)
REACT:R-GGA-190256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to FGF (Gallus gallus)
REACT:R-XTR-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Xenopus tropicalis)
REACT:R-SSC-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Sus scrofa)
RHEA:33177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate(out) => 4-hydroxyphenylacetate(in)
REACT:R-BTA-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Bos taurus)
REACT:R-CEL-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Caenorhabditis elegans)
REACT:R-HSA-2161959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Homo sapiens)
GO:0045148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lymphopeptidase activity
GO:0045148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tripeptide aminopeptidase activity
GO:0045148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidoendopeptidase activity
GO:0045148	skos:prefLabel	"tripeptide aminopeptidase"
GO:0045148	skos:altLabel	"lymphopeptidase"
GO:0045148	skos:altLabel	"peptidase B"
GO:0045148	skos:altLabel	"aminotripeptidase"
GO:0045148	skos:altLabel	"tripeptidase"
GO:0045148	skos:altLabel	"aminoexotripeptidase"
GO:0045148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoexotripeptidase activity
GO:0045148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidase T
GO:0045148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-phenylalanine-proline arylamidase activity
GO:0045148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminotripeptidase activity
GO:0045148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidase B
GO:0045148	skos:altLabel	"imidoendopeptidase"
GO:0045148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tripeptide aminopeptidase"
REACT:R-GGA-2990842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO2 (Gallus gallus)
RHEA:69085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + H2O + NAD(+) => acrylate + 2 H(+) + NADH
REACT:R-BTA-8954082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds the PRC1 complex (Bos taurus)
RHEA:34669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine
REACT:R-MMU-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Mus musculus)
RHEA:37450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetracenomycin F1 <=> H(+) + H2O + tetracenomycin D3
REACT:R-MMU-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Mus musculus)
REACT:R-BTA-442273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV1 is a GEF for Rho/Rac family GTPases (Bos taurus)
RHEA:34966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) <=> Na(+)(out)
REACT:R-BTA-1358798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 binds neuregulin-activated ERBB3 (Bos taurus)
RHEA:30822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoin + H2O <=> allantoate + H(+)
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-diphenol:O2 oxidoreductase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monophenol monooxidase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monophenol monooxygenase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine monooxygenase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyrocatechol oxidase
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-diphenol oxidoreductase
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosinase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phenol oxidase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopa oxidase
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cresolase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorogenic oxidase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catecholase
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monophenol oxidase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-6-hydroxytryptophan oxidase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine-dopa oxidase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prophenol oxidase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monophenol oxygenase
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monophenolase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prophenoloxidase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorogenic acid oxidase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phenolase activity
GO:0004503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-diphenol oxidase activity
REACT:R-RNO-5684882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 is recruited to resected DNA DSBs (Rattus norvegicus)
RHEA:17455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => 5-phospho-beta-D-ribosylamine + ATP + glycine
RHEA:32159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"epoxyqueuosine reductase"
RHEA:32159	skos:prefLabel	"epoxyqueuosine reductase"
RHEA:32159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA
RHEA:32159	skos:altLabel	"oQ reductase"
RHEA:38865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate => phosphate + sucrose 6(F)-phosphate
RHEA:13691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 1-phosphate + H(+) + phosphate => diphosphate + glycerol
REACT:R-DME-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Drosophila melanogaster)
RHEA:16943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylisatin => N-acetylindoxyl + O2
REACT:R-CFA-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Canis familiaris)
REACT:R-GGA-8876616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND6A,B exchange GTP for GDP on RAB14 (Gallus gallus)
RHEA:41063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:44728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)
REACT:R-XTR-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Xenopus tropicalis)
REACT:R-DME-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Drosophila melanogaster)
RHEA:24802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-glutamate
REACT:R-GGA-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Gallus gallus)
RHEA:38200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-8851827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Rattus norvegicus)
REACT:R-CFA-3371467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates HSF1 (Canis familiaris)
REACT:R-SSC-187828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p21 to the nucleus (Sus scrofa)
REACT:R-SSC-177944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)
RHEA:15310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]
RHEA:33849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + tetracosanoate => H2O + N-tetracosanoyl-(4R)-hydroxysphinganine
REACT:R-MMU-265425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with von Willbrand Factor (Mus musculus)
REACT:R-BTA-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Bos taurus)
REACT:R-CFA-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Canis familiaris)
REACT:R-RNO-5159250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF7IP binds SETDB1 (Rattus norvegicus)
REACT:R-GGA-9610152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Gallus gallus)
RHEA:28718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate(in) + 2 H(+)(in) <=> (R)-malate(out) + 2 H(+)(out)
RHEA:36419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine
RHEA:66085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + oxaloacetate => H2O + kynurenate + L-aspartate
REACT:R-HSA-8937744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-7Y-RUNX1 (Homo sapiens)
RHEA:45389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine
RHEA:11503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O <=> 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate
RHEA:69481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP
REACT:R-RNO-2028284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Rattus norvegicus)
GO:0015424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled amino acid transmembrane transporter activity
GO:0015424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type amino acid transporter activity
GO:0015424	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	amino acid ABC transporter
GO:0015424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amino acid-importing ATPase activity
GO:0015424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent amino acid transmembrane transporter activity
GO:0015424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid-transporting ATPase activity
GO:0015424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amino acid-exporting ATPase activity
REACT:R-DRE-6805638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A acetylates TP53 (Danio rerio)
RHEA:18724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> diphosphate + ent-13-epi-manoyl oxide
REACT:R-SSC-8952996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 forms homodimers (Sus scrofa)
RHEA:38623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA
GO:0008966	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucosamine 1,6-phosphomutase activity
GO:0008966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglucosamine mutase activity
GO:0008966	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucosamine 1,6-phosphomutase activity
RHEA:11299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate + H2O + NADP(+) <=> 2-oxoglutarate + 2 H(+) + NADPH
REACT:R-HSA-8871494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORL1 binds APP(18-770) (Homo sapiens)
GO:0050257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin phosphotransferase activity
GO:0050257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavine phosphotransferase activity
GO:0050257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity
GO:0050257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	G-1-P phosphotransferase activity
GO:0050257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity
RHEA:58122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate => ATP + L-seryl-[protein]
REACT:R-DME-1592436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP9 by MMPs (Drosophila melanogaster)
RHEA:42457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methylzymosterol => zymosterol
GO:0016815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles
GO:0016815	skos:prefLabel	"In nitriles"
GO:0016815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In nitriles"
REACT:R-BTA-158982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Bos taurus)
RHEA:61906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + stemphyloxin II => betaenone A + H(+) + NADPH + O2
GO:0003950	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(ADP-ribose) synthetase activity
GO:0003950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ ADP-ribosyltransferase activity
GO:0003950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD ADP-ribosyltransferase activity
GO:0003950	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity
GO:0003950	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(ADP-ribose) synthase activity
GO:0003950	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-ribosyltransferase (polymerizing) activity
GO:0003950	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(ADP-ribose)polymerase activity
GO:0003950	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(adenosine diphosphate ribose) polymerase activity
REACT:R-CFA-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Canis familiaris)
REACT:R-HSA-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Homo sapiens)
REACT:R-HSA-209573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Homo sapiens)
RHEA:55288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetradecan-1-ol + tetradecanoyl-CoA = CoA + tetradecanyl tetradecanoate
RHEA:69535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate <=> 4-amino-4-deoxychorismate
GO:0033296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnose binding
GO:0102346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-cerotoyl-CoA dehydratase activity
REACT:R-HSA-6783681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIF binds LIFR (Homo sapiens)
GO:0018726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-phenanthrol sulphotransferase activity
GO:0018726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-phenanthrol sulfotransferase activity
REACT:R-DRE-8847968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN binds FRK (Danio rerio)
REACT:R-XTR-419389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA-binding receptors bind LPA (Xenopus tropicalis)
REACT:R-DRE-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Danio rerio)
REACT:R-GGA-5693536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDC1 (Gallus gallus)
RHEA:25659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] => (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH
RHEA:40524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + succinate => a quinol + fumarate
RHEA:23806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine 6-phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate
GO:0005416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation:amino acid symporter activity
GO:0005416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation/amino acid symporter activity
GO:0005416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid:cation symporter activity
REACT:R-XTR-158145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Xenopus tropicalis)
REACT:R-MMU-196372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Mus musculus)
RHEA:10091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + UDP-alpha-D-galactose <=> 6(F)-alpha-D-galactosylsucrose + H(+) + UDP
REACT:R-HSA-379464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DOPAC to form HVA (Homo sapiens)
REACT:R-MMU-450827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Mus musculus)
RHEA:59083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)
REACT:R-SSC-177934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR autophosphorylation (Sus scrofa)
REACT:R-DRE-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Danio rerio)
RHEA:69157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermine dialdehyde => acrolein + N-(4-aminobutyl)-3-aminopropanal
RHEA:67363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-threonyl-L-threonine <=> 2 L-threonine
RHEA:22897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)
RHEA:26280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-4 + S-adenosyl-L-methionine <=> Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-514604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Xenopus tropicalis)
REACT:R-DME-8931648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Drosophila melanogaster)
RHEA:18331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S)-sabinone + H(+) + NADH => (1S,3R,5S)-sabinol + NAD(+)
REACT:R-PFA-1482543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Plasmodium falciparum)
REACT:R-DRE-201629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Tau (Danio rerio)
RHEA:21042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:54024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate
REACT:R-CFA-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Canis familiaris)
RHEA:15332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + NAD(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADH
RHEA:43637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) => 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-BTA-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Bos taurus)
RHEA:67825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O => a lipid X + 2 H(+) + UMP
RHEA:59362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + L-histidine => carnosine + H2O
RHEA:33281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Gallus gallus)
REACT:R-BTA-374787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR neuropeptide receptor binds neuropeptides B and W (Bos taurus)
REACT:R-HSA-2404199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:IGF1R autophosphorylates (Homo sapiens)
GO:0047867	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)
GO:0047867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylmalate dehydrogenase activity
GO:0047867	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta,beta-dimethylmalate dehydrogenase activity
GO:0034190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein receptor binding
RHEA:57666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-valencene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Mus musculus)
REACT:R-SSC-6786058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL4-bound IL4R1 (Sus scrofa)
REACT:R-HSA-198731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 activates ELK1 (Homo sapiens)
REACT:R-GGA-140978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex binds FADD (Gallus gallus)
RHEA:69553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + L-glutamate => (S)-serinol phosphate + 2-oxoglutarate
RHEA:20222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + ATP + formate => (6S)-10-formyltetrahydrofolate + ADP + phosphate
REACT:R-DRE-6814153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADO oxidises 2AET to HTAU (Danio rerio)
REACT:R-HSA-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Homo sapiens)
REACT:R-RNO-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Rattus norvegicus)
REACT:R-RNO-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Rattus norvegicus)
REACT:R-HSA-8874184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L1 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)
EC:3.4.13.17	skos:altLabel	"D-(or L-)aminoacyl-dipeptidase"
EC:3.4.13.17	skos:prefLabel	"non-stereospecific dipeptidase"
EC:3.4.13.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"non-stereospecific dipeptidase"
EC:3.4.13.17	skos:altLabel	"peptidyl-D-amino acid hydrolase"
GO:0031895	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	V1B vasopressin receptor ligand
GO:0031895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	V1B vasopressin receptor binding
REACT:R-CFA-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Canis familiaris)
REACT:R-BTA-429016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 is phosphorylated by MAPKAP2 (Bos taurus)
REACT:R-HSA-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Homo sapiens)
REACT:R-MMU-606287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSF complex binds the centromere (Mus musculus)
REACT:R-SSC-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Sus scrofa)
RHEA:50600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]
RHEA:45637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
GO:0019107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyltransferase activity
REACT:R-DRE-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Danio rerio)
RHEA:35040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine(in) => spermidine(out)
REACT:R-SSC-5694435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 and MIA3 load procollagen VII into COPII vesicles (Sus scrofa)
REACT:R-SSC-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Sus scrofa)
RHEA:19798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + H2O => 1D-myo-inositol 1,4-bisphosphate + phosphate
RHEA:62894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 CO2 + 7 CoA + 2 H2O + nor-toralactone => acetyl-CoA + 6 H(+) + 6 malonyl-CoA
GO:0009671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(chlorate):hydrogen symporter activity
GO:0009671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate:proton symporter activity
GO:0009671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(chlorate):proton symporter activity
GO:0009671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate:hydrogen symporter activity
GO:0004774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate-CoA ligase activity
REACT:R-CFA-433101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Canis familiaris)
REACT:R-HSA-9013111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)
EC:3.4.23.43	skos:prefLabel	"prepilin peptidase"
EC:3.4.23.43	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prepilin peptidase"
REACT:R-XTR-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Xenopus tropicalis)
GO:0033716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside oxidase (hydrogen peroxide-forming) activity
GO:0033716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside:oxygen 5'-oxidoreductase (hydrogen peroxide-forming) activity
REACT:R-DRE-5687091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 binds MAPKAPK5 (Danio rerio)
REACT:R-XTR-392835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 sequesters Raf1 to inhibit ERK cascade (Xenopus tropicalis)
RHEA:39306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA <=> (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O
REACT:R-SCE-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Saccharomyces cerevisiae)
RHEA:10278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+)
RHEA:25889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + iminosuccinate => H(+) + 2 H2O + phosphate + quinolinate
REACT:R-SPO-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Schizosaccharomyces pombe)
GO:0019843	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	base pairing with rRNA
GO:0019843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA binding
REACT:R-HSA-2076392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcA to heparan (Homo sapiens)
RHEA:65433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)
REACT:R-BTA-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Bos taurus)
RHEA:20409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN
RHEA:20409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"riboflavin phosphotransferase"
RHEA:20409	skos:prefLabel	"riboflavin phosphotransferase"
GO:0051429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRH receptor binding
GO:0051429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR binding
GO:0051429	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	corticotropin releasing factor receptor ligand
GO:0051429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin releasing factor receptor binding
GO:0051429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRF receptor binding
GO:0051429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin-releasing factor receptor binding
GO:0051429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin-releasing hormone receptor binding
RHEA:16827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + UMP => ATP + uridine
GO:0097258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-leukotriene B4 omega-oxidase activity
GO:0097258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-leukotriene B4 omega oxidase activity
GO:0097258	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	20-hydroxy-leukotriene B4 omega-oxidation
REACT:R-HSA-2076220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
RHEA:17859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate => O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate
GO:0047905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)
GO:0047905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose-6-phosphate phosphoketolase activity
GO:0047905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity
REACT:R-SSC-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Sus scrofa)
RHEA:52817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:69634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
RHEA:62433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in tRNA + S-adenosyl-L-methionine => a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine
REACT:R-GGA-201443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II receptor phosphorylates type I receptor (Gallus gallus)
GO:0047247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity
GO:0047247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity
GO:0047247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity
GO:0047247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity
GO:0047247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LDT
GO:0047247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity
GO:0047247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity
REACT:R-BTA-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Bos taurus)
RHEA:35046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(4-aminobenzoyl)-L-glutamate(in) <=> N-(4-aminobenzoyl)-L-glutamate(out)
REACT:R-PFA-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Plasmodium falciparum)
RHEA:43451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:38233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA => (9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA
RHEA:56013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)
REACT:R-MMU-9758674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 oxidizes PREDN,PREDL (Mus musculus)
REACT:R-SCE-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Saccharomyces cerevisiae)
GO:0030369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICAM-3 receptor activity
REACT:R-XTR-5687094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 phosphorylate MAPKAPK5 (Xenopus tropicalis)
REACT:R-RNO-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Rattus norvegicus)
REACT:R-RNO-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)
REACT:R-GGA-4084976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)
RHEA:26503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + UDP
REACT:R-RNO-909738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)
REACT:R-BTA-1181149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Bos taurus)
REACT:R-DRE-8877760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Danio rerio)
REACT:R-BTA-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Bos taurus)
REACT:R-DRE-180073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Danio rerio)
REACT:R-MMU-8850326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds self-lipid-based antigen via CD1 (Mus musculus)
REACT:R-BTA-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Bos taurus)
GO:1990430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular matrix protein binding
RHEA:19213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an S-substituted L-cysteine = an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)
RHEA:19213	skos:prefLabel	"cysteine-S-conjugate N-acetyltransferase"
RHEA:19213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine-S-conjugate N-acetyltransferase"
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-phosphatidylinositol-4-phosphate kinase, class IB
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1-phosphatidylinositol-4-phosphate kinase activity
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PIP kinase activity
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	diphosphoinositide kinase activity
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PtdIns(4)P-5-kinase activity
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-phosphatidylinositol-4-phosphate kinase, class IA
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylinositol 4-phosphate kinase activity
GO:0016308	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type I PIP kinase activity
RHEA:66711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate
RHEA:12194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-DRE-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Danio rerio)
REACT:R-DME-214847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
REACT:R-SSC-1889981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Sus scrofa)
EC:3.2.1.2	skos:altLabel	"4-alpha-D-glucan maltohydrolase"
EC:3.2.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-amylase"
EC:3.2.1.2	skos:altLabel	"saccharogen amylase"
EC:3.2.1.2	skos:prefLabel	"beta-amylase"
EC:3.2.1.2	skos:altLabel	"glycogenase"
GO:0015137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tricarboxylate transport protein
GO:0015137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate transmembrane transporter activity
REACT:R-GGA-430073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Gallus gallus)
RHEA:19625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine = acetaldehyde + glycine
REACT:R-HSA-392054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)
RHEA:17672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)
REACT:R-CFA-8943040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF polyubiquitinates monoubiquitinated PCNA (Canis familiaris)
GO:0098617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APSe is phosphorylated to PAPSe by PAPSS1,2 (Homo sapiens)
GO:0098617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylylselenate kinase activity
REACT:R-SPO-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Schizosaccharomyces pombe)
REACT:R-HSA-5661122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2R3-histone H3 (Homo sapiens)
RHEA:26008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP => di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate
REACT:R-MMU-156661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Exon Junction Complex (Mus musculus)
RHEA:31572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 => CO2 + H2O + NADP(+) + naphthalene-1,2-diol
RHEA:70441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2
RHEA:12555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> (E)-pinosylvin + 4 CO2 + 4 CoA
REACT:R-GGA-372855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)
REACT:R-MMU-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Mus musculus)
REACT:R-DRE-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Danio rerio)
RHEA:54823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-HSA-8986972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24 binds IL20RA:JAK1:IL20RB (Homo sapiens)
REACT:R-CFA-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Canis familiaris)
RHEA:28917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + H(+)(out) => 4-aminobutanoate(in) + H(+)(in)
RHEA:22319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxydocosanoate + UDP-alpha-D-glucose <=> 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP
REACT:R-GGA-5654669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Gallus gallus)
RHEA:52242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 2 MnO2 => 2 H2O + 2 Mn(2+) + O2
RHEA:46390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-2029460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates LIMK1 (Homo sapiens)
REACT:R-XTR-8931648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Xenopus tropicalis)
RHEA:15410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine
RHEA:72513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + 2-oxoglutarate(out) => (R)-carnitine(out) + 2-oxoglutarate(in)
RHEA:25401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
RHEA:41545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine
GO:0009975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclase activity
REACT:R-MMU-158925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Mus musculus)
RHEA:54357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + H(+) => 2-methylpropanal + CO2
RHEA:17325	skos:prefLabel	"2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase"
RHEA:17325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase"
RHEA:17325	skos:altLabel	"tetrahydrodipicolinate succinylase"
RHEA:17325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA
RHEA:17325	skos:altLabel	"tetrahydrodipicolinate N-succinyltransferase"
RHEA:17325	skos:altLabel	"tetrahydrodipicolinate succinyltransferase"
RHEA:17325	skos:altLabel	"succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase"
RHEA:38520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)
REACT:R-BTA-8944250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXV (Bos taurus)
REACT:R-BTA-5690245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 binds DNAJB1 (Bos taurus)
RHEA:64971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O <=> dUDP + H(+) + phosphate
RHEA:65268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypentacecilide A + H(+) + NADPH + O2 = chrodrimanin F + H2O + NADP(+)
RHEA:46155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + a plastoquinone <=> 15,9'-di-cis-phytofluene + a plastoquinol
REACT:R-GGA-2028651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Gallus gallus)
RHEA:47294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-927813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
REACT:R-GGA-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Gallus gallus)
REACT:R-CEL-6798257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRS binds NTRK3 (Caenorhabditis elegans)
RHEA:60753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone => CoA + jasmolin I
REACT:R-SPO-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
RHEA:27302	skos:prefLabel	"7-chloro-L-tryptophan oxidase"
RHEA:27302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 = 2-iminio-3-(indol-3-yl)propanoate + H2O2
RHEA:27302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2
RHEA:27302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-chloro-L-tryptophan oxidase"
REACT:R-BTA-8874204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3 (Bos taurus)
RHEA:14119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O
RHEA:17451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-linalylflaviolin + diphosphate => (2E)-geranyl diphosphate + flaviolin
RHEA:31295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-hydroxypenta-2,4-dienoate = 2-oxopent-4-enoate
RHEA:66939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + 5-hydroxyanthranilate <=> avenanthramide C + CoA
REACT:R-DDI-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Dictyostelium discoideum)
RHEA:31010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> beta-amyrin
GO:0016464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAA chloroplast protein-transporting ATPase
GO:0016464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroplast protein-transporting ATPase activity
GO:0016464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled chloroplast protein transporter activity
RHEA:24468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+)
REACT:R-GGA-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Gallus gallus)
GO:0102858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-18:3-phosphatidylcholine desaturase activity
REACT:R-SSC-163751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Sus scrofa)
REACT:R-MMU-977371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates Factor H-boundC3b (Mus musculus)
REACT:R-XTR-1236940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exogenous soluble antigen targeted to more stable early endosome (Xenopus tropicalis)
REACT:R-MMU-173597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)
REACT:R-CFA-9640168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Canis familiaris)
REACT:R-DME-8953461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Drosophila melanogaster)
REACT:R-MMU-5333671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCAs self cleave (Mus musculus)
REACT:R-HSA-9638064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Homo sapiens)
RHEA:49572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)
RHEA:49572	skos:prefLabel	"coproporphyrin ferrochelatase"
RHEA:49572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coproporphyrin ferrochelatase"
RHEA:58536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoylglycine
REACT:R-GGA-176175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Stalling of DNA replication fork and RPA binding (Gallus gallus)
REACT:R-DME-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Drosophila melanogaster)
REACT:R-SSC-2187358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters unphosphorylated SMAD2/3 (Sus scrofa)
REACT:R-RNO-4793925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S303,307-HSF1 binds YWHAE (14-3-3) (Rattus norvegicus)
REACT:R-DRE-1475414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Danio rerio)
RHEA:10293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-glucosamine 6-phosphate => CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate
REACT:R-GGA-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)
REACT:R-GGA-6814682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of early-endosome derived vesicles at the TGN (Gallus gallus)
REACT:R-GGA-5218819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
EC:3.4.15.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidyl-dipeptidase Dcp"
EC:3.4.15.5	skos:prefLabel	"peptidyl-dipeptidase Dcp"
EC:3.4.15.5	skos:altLabel	"dipeptidyl carboxypeptidase"
RHEA:71820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-thyroxine(out) => L-thyroxine(in)
RHEA:62241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine(6-4)cytidine in DNA => a thymine-cytidine dinucleotide in DNA
REACT:R-HSA-1237047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ hydrates CO2 to HCO3- (Homo sapiens)
REACT:R-RNO-6784791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Rattus norvegicus)
RHEA:67751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate
REACT:R-SSC-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Sus scrofa)
REACT:R-MMU-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Mus musculus)
GO:0008429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylethanolamine binding
RHEA:33860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S-3S)-versiconal hemiacetal => H2O + versicolorin B
RHEA:16947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein]
RHEA:16691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + phosphate => D-glucose 6-phosphate + H2O
REACT:R-HSA-9718379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds chemical antagonists (Homo sapiens)
REACT:R-DME-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Drosophila melanogaster)
REACT:R-CFA-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Canis familiaris)
RHEA:63021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienamide + H2O => (9Z,12Z)-octadecadienoate + NH4(+)
RHEA:31442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> alpha-longipinene + diphosphate
REACT:R-DME-8938853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 binds RUNX1 (Drosophila melanogaster)
REACT:R-HSA-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Homo sapiens)
GO:0140475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spindle pole body anchor activity
RHEA:15860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADPH
RHEA:33914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-alkylglycine + H2O + O2 <=> an alkylamine + glyoxylate + H2O2
REACT:R-SSC-8874470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Sus scrofa)
RHEA:12547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine <=> 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate
RHEA:44421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)
REACT:R-DDI-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Dictyostelium discoideum)
GO:0051500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tyrosyl-tRNA(Tyr) deacylase activity
RHEA:64397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-sarcosine(out) + H(+)(out) => glycyl-sarcosine(in) + H(+)(in)
RHEA:52318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate
RHEA:25258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine 6-phosphate => N-acetyl-D-mannosamine 6-phosphate
RHEA:53797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholoyl-CoA + ursodeoxycholate => deoxycholate + ursodeoxycholoyl-CoA
RHEA:38511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)
RHEA:39959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate
REACT:R-GGA-2424487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)
RHEA:40180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + O2 => (2E)-decenoyl-CoA + H2O2
REACT:R-HSA-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)
RHEA:37099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP
REACT:R-HSA-9796368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 binds STUB1 (Homo sapiens)
RHEA:37308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-asparagine + H2O => glycine + L-asparagine
REACT:R-MMU-9750946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
GO:0032448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA hairpin binding
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol polyphosphate-5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	InsP3/Ins(1,3,4,5)P4 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol trisphosphate phosphomonoesterase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ins(1,4,5)P(3) 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type I inositol-polyphosphate phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myo-inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol triphosphate 5-phosphomonoesterase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol 1,4,5-trisphosphate phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ins(1,4,5)P3 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-myo-inositol 1,4,5-trisphosphate-monoesterase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5PTase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II inositol polyphosphate 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol phosphate 5-phosphomonoesterase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type II inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-polyphosphate 5-phosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine triphosphatase activity
GO:0004445	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity
REACT:R-MMU-9020264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Mus musculus)
RHEA:53736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-halobenzoate + H(+) + NADH + O2 = a halide anion + catechol + CO2 + NAD(+)
REACT:R-GGA-420127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGRP receptor can bind calcitonin gene-related peptides (Gallus gallus)
REACT:R-MMU-211968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2W1 oxidises INDOL (Mus musculus)
REACT:R-CEL-9008822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1D dephosphorylates RUNX2 (Caenorhabditis elegans)
REACT:R-DME-9614271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ADGRG6 (Drosophila melanogaster)
RHEA:63633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-AMP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + H(+)
GO:0052758	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	TNP reductase activity
GO:0052758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent 2,4,6-trinitrophenol hydride transferase activity
GO:0052758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity
REACT:R-HSA-8874198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L2 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)
RHEA:55449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-9011985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Gallus gallus)
GO:0047601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate-acetate phosphotransferase activity
GO:0047601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate kinase (diphosphate) activity
GO:0047601	skos:altLabel	"Acetate kinase (pyrophosphate)"
GO:0047601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetate kinase (pyrophosphate) activity
GO:0047601	skos:prefLabel	"acetate kinase (diphosphate)"
GO:0047601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphate:acetate phosphotransferase activity
GO:0047601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetate kinase (diphosphate)"
GO:0047601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + diphosphate = acetyl phosphate + phosphate
RHEA:30171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]
GO:0008193	skos:altLabel	"histidine tRNA guanylyltransferase"
GO:0008193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA guanylyltransferase activity
GO:0008193	skos:prefLabel	"tRNA(His) guanylyltransferase"
GO:0008193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(His) guanylyltransferase"
GO:0008193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)
REACT:R-HSA-5687099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter (Homo sapiens)
RHEA:64252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycine
RHEA:58022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eupatolide + H2O => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)
REACT:R-BTA-561253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A12 exchanges extracellular urate for cytosolic LACT (Bos taurus)
REACT:R-GGA-5656064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FLRT1,2,3 (Gallus gallus)
REACT:R-XTR-1602374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Xenopus tropicalis)
RHEA:71868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate(out) => glycodeoxycholate(in)
GO:0034935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrachlorobenzene dioxygenase activity
REACT:R-HSA-6796649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the CCNK gene (Homo sapiens)
RHEA:16185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH
RHEA:37669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine
RHEA:19763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + H2O + NAD(+) => FMN-N(5)-oxide + H(+) + NADH
GO:0033433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUU codon-amino acid adaptor activity
GO:0033433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATT codon-amino acid adaptor activity
GO:0033433	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoleucine tRNA
REACT:R-BTA-1602417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Bos taurus)
RHEA:67042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asnovolin H => (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+)
RHEA:40222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonyl-CoA <=> CoA + H(+) + malonate
REACT:R-DME-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)
REACT:R-PFA-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Plasmodium falciparum)
REACT:R-HSA-2220981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)
REACT:R-MMU-443439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-Src binds Raf1 (Mus musculus)
REACT:R-SSC-209532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR C-terminal fragment enters endosomes (Sus scrofa)
RHEA:71818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine(out) <=> 3,3',5'-triiodo-L-thyronine(in)
REACT:R-GGA-2132136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vitronectin binds to C5b-C7 complex (Gallus gallus)
REACT:R-BTA-5159250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF7IP binds SETDB1 (Bos taurus)
RHEA:21955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-pregnane-3,20-dione + NADP(+) <=> H(+) + NADPH + progesterone
REACT:R-BTA-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Bos taurus)
RHEA:43931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pregn-5-ene-3,20-dione <=> progesterone
REACT:R-CFA-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Canis familiaris)
REACT:R-SSC-211190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of DFF45 (117) (Sus scrofa)
REACT:R-BTA-197250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)
RHEA:44130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanyl (9E)-octadecenoate => (9E)-octadecenoyl-CoA + hexadecan-1-ol
REACT:R-SSC-9013111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GAPs stimulate RHOC GTPase activity (Sus scrofa)
RHEA:55858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:69307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-glucotropeolin + H2O <=> (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
REACT:R-SSC-193845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)
RHEA:20377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3(or 17)alpha-hydroxysteroid dehydrogenase"
RHEA:20377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH
RHEA:20377	skos:prefLabel	"3(or 17)alpha-hydroxysteroid dehydrogenase"
RHEA:20377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH
REACT:R-DRE-2168889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin-related Protein binds Hemoglobin (Danio rerio)
RHEA:47209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-8848873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARAP1 (Caenorhabditis elegans)
RHEA:19406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + citrate => (3S)-citryl-CoA + acetate
REACT:R-DRE-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Danio rerio)
REACT:R-SCE-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Saccharomyces cerevisiae)
REACT:R-HSA-194310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Homo sapiens)
REACT:R-CFA-163751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Canis familiaris)
REACT:R-SCE-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Saccharomyces cerevisiae)
REACT:R-SSC-8876312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Sus scrofa)
REACT:R-HSA-193801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Influx of 27-hydroxycholesterol (Homo sapiens)
RHEA:70990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(out) + n H(+)(in) <=> beta-alanine(in) + n H(+)(out)
REACT:R-HSA-351877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 2 (Homo sapiens)
REACT:R-RNO-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Rattus norvegicus)
GO:0004854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthine:NAD+ oxidoreductase activity
GO:0004854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-xanthine dehydrogenase activity
GO:0004854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthine-NAD oxidoreductase activity
GO:0004854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthine dehydrogenase activity
GO:0004854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthine/NAD(+) oxidoreductase activity
GO:0004854	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	xanthine oxidoreductase activity
GO:0004854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthine/NAD+ oxidoreductase activity
REACT:R-DRE-6807027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 and PTPN2 dephosphorylate MET (Danio rerio)
RHEA:12044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
RHEA:66621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5693615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Bos taurus)
GO:0015209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine transmembrane transporter activity
REACT:R-CFA-8866327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL translocates from SER lumen to extracellular region (Canis familiaris)
EC:3.2.1.173	skos:altLabel	"RG-galacturonohydrolase"
EC:3.2.1.173	skos:prefLabel	"rhamnogalacturonan galacturonohydrolase"
EC:3.2.1.173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnogalacturonan galacturonohydrolase"
REACT:R-CFA-8854604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D16 accelerates GTP hydrolysis by RAB4A (Canis familiaris)
REACT:R-BTA-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Bos taurus)
RHEA:11222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine
REACT:R-GGA-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Gallus gallus)
RHEA:44653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine
REACT:R-SSC-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Sus scrofa)
REACT:R-CFA-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Canis familiaris)
RHEA:53851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + taurocholate <=> 7-oxo-taurodeoxycholate + H(+) + NADH
RHEA:13987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-homoserine => ATP + L-homoserine
GO:0046527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosyltransferase activity
REACT:R-HSA-443817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by EPHB2 (Homo sapiens)
REACT:R-CFA-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Canis familiaris)
RHEA:38449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose => 4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O
RHEA:36883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0005525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP binding
GO:0005525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex  binds GTP (Homo sapiens)
GO:0102777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity
REACT:R-DRE-6805426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD8 binds CASP9(1-416) (Danio rerio)
REACT:R-RNO-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Rattus norvegicus)
REACT:R-SSC-9014074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin4 (Sus scrofa)
REACT:R-MMU-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Mus musculus)
RHEA:28849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Li(+)(out) + melibiose(out) => Li(+)(in) + melibiose(in)
GO:0004900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythropoietin receptor activity
REACT:R-HSA-9640237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)
REACT:R-HSA-9694568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)
REACT:R-MMU-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Mus musculus)
REACT:R-XTR-421833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Xenopus tropicalis)
RHEA:15574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylserotonin + S-adenosyl-L-methionine => H(+) + melatonin + S-adenosyl-L-homocysteine
REACT:R-SSC-8849797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane proteases cleave Profilaggrin producing Filaggrin (Sus scrofa)
RHEA:53515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate
REACT:R-DDI-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Dictyostelium discoideum)
REACT:R-MMU-2248891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARSA translocates to the lysosome (Mus musculus)
REACT:R-MMU-5610746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI3 (Mus musculus)
RHEA:50739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + 2 H(+) + hydrogen sulfide + sulfite <=> a quinol + thiosulfate
REACT:R-HSA-9014141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEY2 gene expression is positively regulated by NOTCH3 (Homo sapiens)
REACT:R-CFA-5662692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is oxidized to dopaquinone by TYR (Canis familiaris)
RHEA:50469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH => 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)
REACT:R-MMU-3772430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNBIP1 binds beta-catenin (Mus musculus)
RHEA:42466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+) => biphenyl-2,2',3-triol + O2
RHEA:24109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methyl-2-oxoglutaramate => 2-oxoglutarate + methylamine
RHEA:18811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminomalonate + pyruvate => L-alanine + oxomalonate
RHEA:34803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = bisdemethoxycurcumin + 2 CO2 + 3 CoA
RHEA:34803	skos:prefLabel	"bisdemethoxycurcumin synthase"
RHEA:34803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bisdemethoxycurcumin synthase"
RHEA:34803	skos:altLabel	"curcuminoid synthase"
RHEA:28106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactitol-1-phosphate 5-dehydrogenase"
RHEA:28106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol 1-phosphate + NAD(+) = H(+) + keto-D-tagatose 6-phosphate + NADH
RHEA:28106	skos:prefLabel	"galactitol-1-phosphate 5-dehydrogenase"
RHEA:30953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
GO:0016696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor
GO:0016696	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0016696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
REACT:R-SSC-6803753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAAA hydrolyses NAEs to FAs and ethanolamine (Sus scrofa)
REACT:R-XTR-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Xenopus tropicalis)
RHEA:64518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NAD(+)
RHEA:41961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GA1 (d18:1(4E)) + H(+) + UDP
REACT:R-SSC-372705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of BCAR1 to PTK2 complex (Sus scrofa)
REACT:R-SPO-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Schizosaccharomyces pombe)
REACT:R-SSC-8948063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Sus scrofa)
REACT:R-DRE-177923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sustained activation of SRC kinase by SHP2 (Danio rerio)
RHEA:20848	skos:altLabel	"phosphate-dependent pyruvate oxidase"
RHEA:20848	skos:altLabel	"pyruvic oxidase"
RHEA:20848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2
RHEA:20848	skos:prefLabel	"pyruvate oxidase"
RHEA:20848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate oxidase"
RHEA:64732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate
REACT:R-SSC-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Sus scrofa)
REACT:R-RNO-8858252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDLBP binds HDL (Rattus norvegicus)
RHEA:60134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2
RHEA:10022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH => H2O + L-saccharopine + NADP(+)
REACT:R-GGA-9013021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOB (Gallus gallus)
GO:0052745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol phosphate phosphatase activity
REACT:R-CEL-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Caenorhabditis elegans)
REACT:R-DRE-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Danio rerio)
RHEA:45247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-octadienoyl-CoA <=> (2E,4E)-octadienoyl-CoA
EC:2.4.1.69	skos:altLabel	"alpha-2-L-fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase"
EC:2.4.1.69	skos:prefLabel	"type 1 galactoside alpha-(1,2)-fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"blood group H alpha-2-fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"guanosine diphosphofucose-galactoside 2-L-fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"alpha-(1->2)-L-fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"beta-galactoside alpha1->2 fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"alpha-2-fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"blood-group substance H-dependent fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"secretor-type beta-galactoside alpha1->2 fucosyltransferase"
EC:2.4.1.69	skos:altLabel	"galactoside 2-alpha-L-fucosyltransferase"
EC:2.4.1.69	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"type 1 galactoside alpha-(1,2)-fucosyltransferase"
REACT:R-XTR-3000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BORA binds SCF-beta-TrCp1/2 (Xenopus tropicalis)
RHEA:22111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine <=> 2-oxobutanoate + NH4(+)
REACT:R-CFA-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Canis familiaris)
REACT:R-CEL-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Caenorhabditis elegans)
RHEA:28155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:48693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
REACT:R-SCE-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)
RHEA:27518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine
REACT:R-PFA-429786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Plasmodium falciparum)
REACT:R-RNO-174202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Securin (Rattus norvegicus)
RHEA:29790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O <=> ADP + glutathione(out) + H(+) + phosphate
RHEA:39380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)
REACT:R-DRE-8851827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Danio rerio)
RHEA:14387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + H(+) + phosphate => a dolichyl diphosphate + H2O
RHEA:59108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + octyl beta-D-glucose = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol
REACT:R-BTA-177479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Axonal transport of NGF:Trk complexes (Bos taurus)
REACT:R-SSC-2309779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer binds PTGS2 inhibitors (Sus scrofa)
RHEA:31851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = parkeol
RHEA:31851	skos:prefLabel	"parkeol synthase"
RHEA:31851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"parkeol synthase"
RHEA:60478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-cAAG + 3 diphosphate => 2 ATP + GTP
REACT:R-MMU-5649705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Mus musculus)
REACT:R-HSA-9761846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent PGD gene expression (Homo sapiens)
REACT:R-RNO-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
REACT:R-BTA-9706336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SYK (Bos taurus)
REACT:R-CFA-114264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAX to the mitochondria (Canis familiaris)
REACT:R-MMU-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Mus musculus)
RHEA:40389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP
REACT:R-HSA-6784160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
RHEA:28098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GDP = AMP + guanosine 3',5'-bis(diphosphate)
RHEA:65962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + leukotriene C4(in) + phosphate => ATP + H2O + leukotriene C4(out)
RHEA:56731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-all-trans-beta-carotene + AH2 + O2 <=> 4,4-dihydroxy-all-trans-beta-carotene + A + H2O
REACT:R-SSC-8938356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RMB14 binds RUNX2 (Sus scrofa)
RHEA:29277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(out) + Na(+)(out) => L-isoleucine(in) + Na(+)(in)
REACT:R-BTA-6788582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 phosphorylation (Bos taurus)
REACT:R-GGA-5693533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C (ARTEMIS) processes DNA DSB ends (Gallus gallus)
REACT:R-XTR-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Xenopus tropicalis)
RHEA:55606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base
RHEA:14040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5beta-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH
RHEA:21978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + adenosine 5'-phosphosulfate => [thioredoxin]-disulfide + AMP + 2 H(+) + sulfite
REACT:R-BTA-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Bos taurus)
RHEA:70303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine
REACT:R-SSC-8937177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD binds ARNT (Sus scrofa)
REACT:R-GGA-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Gallus gallus)
RHEA:13613	skos:altLabel	"6-phosphofructokinase (diphosphate)"
RHEA:13613	skos:altLabel	"6-phosphofructokinase (pyrophosphate)"
RHEA:13613	skos:altLabel	"pyrophosphate--fructose 6-phosphate 1-phosphotransferase"
RHEA:13613	skos:altLabel	"pyrophosphate-dependent 6-phosphofructose-1-kinase"
RHEA:13613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diphosphate--fructose-6-phosphate 1-phosphotransferase"
RHEA:13613	skos:altLabel	"diphosphate-dependent 6-phosphofructose-1-kinase"
RHEA:13613	skos:prefLabel	"diphosphate--fructose-6-phosphate 1-phosphotransferase"
RHEA:13613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate
REACT:R-HSA-5685319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex formation (Homo sapiens)
RHEA:25303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)
REACT:R-SCE-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Saccharomyces cerevisiae)
REACT:R-BTA-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Bos taurus)
EC:4.1.1.29	skos:prefLabel	"sulfinoalanine decarboxylase"
EC:4.1.1.29	skos:altLabel	"cysteinesulfinic acid decarboxylase"
EC:4.1.1.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfinoalanine decarboxylase"
EC:4.1.1.29	skos:altLabel	"3-sulfino-L-alanine carboxy-lyase"
EC:4.1.1.29	skos:altLabel	"CSADCase"
EC:4.1.1.29	skos:altLabel	"cysteine-sulfinate decarboxylase"
REACT:R-SSC-2168888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha1-Microglobulin binds heme (Sus scrofa)
RHEA:47669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) => 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
EC:3.4.24.46	skos:prefLabel	"adamalysin"
EC:3.4.24.46	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adamalysin"
EC:3.4.24.46	skos:altLabel	"Crotalus adamanteus metalloendopeptidase"
EC:3.4.24.46	skos:altLabel	"proteinase I and II"
REACT:R-HSA-8855508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Homo sapiens)
REACT:R-BTA-202472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TRAF6 to CBM complex (Bos taurus)
RHEA:17137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 = thromboxane A2
RHEA:17137	skos:prefLabel	"thromboxane-A synthase"
RHEA:17137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thromboxane-A synthase"
RHEA:17137	skos:altLabel	"thromboxane synthetase"
RHEA:17137	skos:altLabel	"thromboxane synthase"
REACT:R-MMU-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Mus musculus)
RHEA:44668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)
RHEA:44668	skos:altLabel	"Tar polymerase"
RHEA:44668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"teichoic acid ribitol-phosphate polymerase"
RHEA:44668	skos:prefLabel	"teichoic acid ribitol-phosphate polymerase"
RHEA:68567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin
REACT:R-CFA-5610746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI3 (Canis familiaris)
GO:0110036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2 domain binding
RHEA:47914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O => 6-deoxy-6-sulfo-D-gluconate
REACT:R-DRE-2426450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins:Nidogens binds collagen type IV networks (Danio rerio)
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglycerokinase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphate kinase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-3-phosphoglycerate 1-phosphotransferase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglyceric kinase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoglycerate phosphokinase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerate 3-phosphate kinase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:3-phospho-D-glycerate 1-phosphotransferase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoglycerate kinase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglyceric acid kinase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGK
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglycerate kinase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoglyceric acid phosphokinase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-3-phospho-D-glycerate-1-phosphotransferase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-PGK
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoglyceric kinase activity
GO:0004618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoglyceric acid kinase activity
REACT:R-SSC-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Sus scrofa)
RHEA:67157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-SSC-9724753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds anti-fibrinolytics (Sus scrofa)
RHEA:45842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydecanoyl-CoA + NADP(+)
REACT:R-GGA-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)
REACT:R-SCE-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)
RHEA:71803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(out) + H(+)(out) = acetate(in) + H(+)(in)
REACT:R-HSA-1592270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NID1 degradation by MMP1, 9, 12, ELANE (Homo sapiens)
RHEA:18024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) <=> CMP + ganglioside GD1a (d18:1(4E)) + H(+)
REACT:R-SSC-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Sus scrofa)
REACT:R-MMU-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Mus musculus)
REACT:R-SSC-5672980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF complex (Sus scrofa)
REACT:R-CFA-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Canis familiaris)
REACT:R-XTR-2161890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Xenopus tropicalis)
REACT:R-HSA-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Homo sapiens)
REACT:R-RNO-3827958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by MMP9, KLK7 (Rattus norvegicus)
REACT:R-MMU-209924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is decarboxylated to dopamine (Mus musculus)
REACT:R-HSA-9699575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO3-dependent CDKN1B gene expression (Homo sapiens)
REACT:R-RNO-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Rattus norvegicus)
RHEA:21154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-hydroxy-D-proline => trans-4-hydroxy-L-proline
REACT:R-MMU-77254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Mus musculus)
REACT:R-SCE-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Saccharomyces cerevisiae)
GO:0016638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on the CH-NH2 group of donors"
GO:0016638	skos:prefLabel	"Acting on the CH-NH2 group of donors"
GO:0016638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0016638	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors
GO:0050151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)
GO:0050151	skos:prefLabel	"oleate hydratase"
GO:0050151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-10-hydroxyoctadecanoate = (9Z)-octadecenoate + H2O
GO:0050151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-10-hydroxystearate 10-hydro-lyase activity
GO:0050151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oleate hydratase"
GO:0050151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleate hydratase activity
REACT:R-MMU-190681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in endoplasmic reticulum membrane (Mus musculus)
REACT:R-SSC-1222376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide from oxygen (Sus scrofa)
REACT:R-SSC-1638104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Sus scrofa)
REACT:R-DDI-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Dictyostelium discoideum)
REACT:R-SSC-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Sus scrofa)
REACT:R-RNO-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Rattus norvegicus)
REACT:R-GGA-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Gallus gallus)
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin reductase (NADH) activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide) reductase activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H2 dehydrogenase (FMN) activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:FMN oxidoreductase activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin mononucleotide reductase activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavine mononucleotide reductase activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavine mononucleotide reductase activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:riboflavin oxidoreductase activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H2:FMN oxidoreductase activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin mononucleotide reductase activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H-dependent FMN reductase activity
GO:0052875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H-FMN reductase activity
REACT:R-SCE-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Saccharomyces cerevisiae)
RHEA:42061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + NAD(+) => 11-cis-retinal + H(+) + NADH
RHEA:20474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)
REACT:R-PFA-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Plasmodium falciparum)
REACT:R-HSA-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Homo sapiens)
REACT:R-CEL-2396337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Caenorhabditis elegans)
REACT:R-MMU-168412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP elicits a NOD2 response (Mus musculus)
REACT:R-RNO-5660663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 cleaves IL1B precursor (Rattus norvegicus)
REACT:R-XTR-9731228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)
REACT:R-CFA-73758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Canis familiaris)
REACT:R-DRE-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Danio rerio)
REACT:R-MMU-5682893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12:ATG7:CysO572-ATG7 binds ATG10 (Mus musculus)
RHEA:72200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + 2 H(+)(out) => Ca(2+)(out) + 2 H(+)(in)
REACT:R-GGA-74730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin degradation (Gallus gallus)
RHEA:69364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-diazo-5-oxo-L-norleucine + acetyl-CoA = CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine
RHEA:68319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 2,4,5-triphosphate + phosphate
REACT:R-MMU-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Mus musculus)
REACT:R-SSC-377644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of CSK from SRC (Sus scrofa)
RHEA:61294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)
RHEA:61985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + ubiquinone-10 => NAD(+) + ubiquinol-10
REACT:R-SPO-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Schizosaccharomyces pombe)
RHEA:50367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-9013024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors at the plasma membrane (Danio rerio)
RHEA:36659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + descarbamoylnovobiocin = novobiocin + phosphate
RHEA:36659	skos:prefLabel	"decarbamoylnovobiocin carbamoyltransferase"
RHEA:36659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"decarbamoylnovobiocin carbamoyltransferase"
REACT:R-BTA-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Bos taurus)
REACT:R-HSA-111912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMK4 phosphorylates CREB1 (Homo sapiens)
REACT:R-SSC-2022052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Sus scrofa)
RHEA:13152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H(+) + NADPH <=> AH2 + NADP(+)
REACT:R-DRE-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Danio rerio)
REACT:R-DRE-3132737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate ETS1 and ETS2 (Danio rerio)
RHEA:11271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cysteine + H2O <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate
REACT:R-HSA-8875661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA3 associates with activated MET receptor (Homo sapiens)
RHEA:64528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine
REACT:R-XTR-2574845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA binds centrosome-associated AURKA (Xenopus tropicalis)
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkyl-DHAP synthase activity
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHAP-AT
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkyl-DHAP
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkylglycerone-phosphate synthase"
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkyldihydroxyacetonephosphate synthase activity
GO:0008609	skos:altLabel	"alkyl-DHAP synthase"
GO:0008609	skos:prefLabel	"alkylglycerone-phosphate synthase"
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyacetone-phosphate acyltransferase activity
GO:0008609	skos:altLabel	"alkyldihydroxyacetonephosphate synthase"
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylglycerone-phosphate synthase activity
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkyl DHAP synthetase activity
GO:0008609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkyldihydroxyacetone phosphate synthetase activity
REACT:R-CFA-5654673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Canis familiaris)
REACT:R-CEL-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)
RHEA:53224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Drosophila melanogaster)
REACT:R-DRE-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Danio rerio)
REACT:R-DME-111238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR2  homodimer (Drosophila melanogaster)
REACT:R-CFA-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)
REACT:R-DDI-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Dictyostelium discoideum)
RHEA:21186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + GDP => a dolichyl phosphate + GDP-alpha-D-mannose
REACT:R-HSA-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Homo sapiens)
RHEA:28636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-5-epi-aristolochene + diphosphate
RHEA:43626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetaldehyde + CO2 => 2-aminomalonate semialdehyde + H(+)
RHEA:62617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose => a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)
RHEA:37679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-GGA-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Gallus gallus)
REACT:R-DME-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
REACT:R-DRE-5660980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S276-RELA binds RELB (Danio rerio)
REACT:R-DRE-447252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB1:TYK2 binds IL12RB2:JAK2 (Danio rerio)
REACT:R-DME-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Drosophila melanogaster)
REACT:R-XTR-3341296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX7,8 catalyze peroxidation of P4HB (PDI) (Xenopus tropicalis)
REACT:R-BTA-912727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds VAV (Bos taurus)
GO:0050535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-primeverosidase activity
GO:0050535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	b-primeverosidase activity
GO:0050535	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity
GO:0051401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CH domain binding
GO:0051401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calponin homology domain binding
GO:0004419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl coenzyme A lyase activity
GO:0004419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme A-cleaving enzyme
GO:0004419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme A lyase activity
GO:0004419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HMG-CoA lyase activity
GO:0004419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutarate-CoA lyase activity
GO:0004419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl-CoA lyase activity
GO:0004419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl CoA cleaving enzyme
GO:0004419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity
GO:0004419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylglutaryl-CoA lyase activity
GO:0004419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)
REACT:R-DRE-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Danio rerio)
REACT:R-DME-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Drosophila melanogaster)
REACT:R-GGA-210294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-2 (Gallus gallus)
REACT:R-SPO-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Schizosaccharomyces pombe)
REACT:R-DRE-6809393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filaments bind cell-cell adhesion complexes (Danio rerio)
REACT:R-DRE-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Danio rerio)
REACT:R-CFA-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Canis familiaris)
REACT:R-SSC-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)
REACT:R-BTA-8955010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRTOMT transfers Met to DA, forming 3MT (Bos taurus)
REACT:R-CFA-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Canis familiaris)
RHEA:16809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylisocitrate lyase"
RHEA:16809	skos:altLabel	"(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase"
RHEA:16809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate
RHEA:16809	skos:prefLabel	"methylisocitrate lyase"
REACT:R-RNO-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Rattus norvegicus)
REACT:R-DME-209112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)
REACT:R-XTR-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Xenopus tropicalis)
REACT:R-DRE-9007447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 forms the PRC1L4 complex (Danio rerio)
REACT:R-RNO-5610732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI3 (Rattus norvegicus)
REACT:R-RNO-6787820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds CSF1R (Rattus norvegicus)
REACT:R-CFA-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Canis familiaris)
REACT:R-XTR-4641246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 autoubiquitinates to promote its internalization (Xenopus tropicalis)
REACT:R-RNO-975142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Rattus norvegicus)
RHEA:21509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + H2O => H(+) + hexadecanoate + retinol
RHEA:72155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-glutamate synthase activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-glutamate synthase activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate synthase (NADPH) activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate synthetase (NADP) activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-glutamate synthetase activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-linked glutamate synthase
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent glutamate synthase activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine-ketoglutaric aminotransferase activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GOGAT activity
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH GOGAT
GO:0004355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:NADP+ oxidoreductase (transaminating)
REACT:R-HSA-9705959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 6 binds KPNA2 (Homo sapiens)
RHEA:21210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + phosphate => H2O + O-phospho-L-serine
REACT:R-MMU-209055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A dephosphorylates nuclear SMAD2/3 (Mus musculus)
GO:0047105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-N-trimethylaminobutyraldehyde dehydrogenase activity
GO:0047105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-trimethylammoniobutyraldehyde dehydrogenase activity
GO:0047105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity
GO:0047105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-trimethylaminobutyraldehyde dehydrogenase activity
REACT:R-XTR-5205820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Xenopus tropicalis)
REACT:R-RNO-374337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apelin receptor binds to apelin (Rattus norvegicus)
REACT:R-CEL-71260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Caenorhabditis elegans)
REACT:R-XTR-6786720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DECR2 reduces LCtE-CoA to t3enoyl-CoA (Xenopus tropicalis)
RHEA:62579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-cystine(out) <=> ADP + H(+) + L-cystine(in) + phosphate
RHEA:66362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O
REACT:R-CEL-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)
RHEA:33034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-fructose + NADH <=> D-sorbitol + NAD(+)
RHEA:37123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine
REACT:R-GGA-2168886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemopexin binds Hemes (Gallus gallus)
REACT:R-SSC-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Sus scrofa)
RHEA:70106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + o-quinone methide + penilactone D <=> penilactone B
GO:0042961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled antimonite transmembrane transporter activity
GO:0042961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent antimonite transporter activity
GO:0042961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	antimonite-transporting ATPase activity
REACT:R-GGA-8851979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL9 binds immune cell surfaces (Gallus gallus)
REACT:R-CFA-8855747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Canis familiaris)
REACT:R-RNO-2408524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Rattus norvegicus)
RHEA:17441	skos:altLabel	"cysteine aminotransferase"
RHEA:17441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-cysteine = 2-oxo-3-sulfanylpropanoate + L-glutamate
RHEA:17441	skos:prefLabel	"cysteine transaminase"
RHEA:17441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine transaminase"
RHEA:10811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxypropylphosphonate + H2O2 <=> (1R,2S)-epoxypropylphosphonate + 2 H2O
REACT:R-HSA-112437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NELF complex  (Homo sapiens)
RHEA:58056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypotaurine + pyruvate = 2-sulfinoacetaldehyde + L-alanine
GO:0019894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinesin binding
REACT:R-SSC-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Sus scrofa)
RHEA:48328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))
RHEA:62645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z)-eicosadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-eicosadienoate
REACT:R-RNO-5649708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 recruits POLB to incised AP site (Rattus norvegicus)
REACT:R-DRE-6803719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds ZNF385A (Danio rerio)
RHEA:33470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydroepisterol + H(+) + NADPH + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)
REACT:R-DRE-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Danio rerio)
REACT:R-CEL-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Caenorhabditis elegans)
REACT:R-HSA-9694641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral release (Homo sapiens)
REACT:R-CFA-2024108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some HSPGs are secreted to the plasma membrane (Canis familiaris)
RHEA:10667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + perillyl alcohol <=> H(+) + NADH + perillyl aldehyde
RHEA:71863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurodeoxycholate(out) = taurodeoxycholate(in)
RHEA:27928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMP(out) => UMP(in)
REACT:R-XTR-6804596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1:CYCS binds APIP (Xenopus tropicalis)
REACT:R-RNO-9701003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)
RHEA:37311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-glutamine(out) + H2O = ADP + glycyl-L-glutamine(in) + H(+) + phosphate
REACT:R-XTR-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Xenopus tropicalis)
RHEA:57999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh2 + H(+) + UDP
REACT:R-BTA-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Bos taurus)
RHEA:54349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:62703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + naphtopyrone YWA1 <=> acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol
REACT:R-BTA-5620914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF4:GTP binds VxPx-motifs of membrane proteins (Bos taurus)
REACT:R-CFA-9008271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Canis familiaris)
REACT:R-GGA-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Gallus gallus)
REACT:R-BTA-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Bos taurus)
REACT:R-HSA-2318623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan binds Hyaluronan and HAPLN1 (Homo sapiens)
REACT:R-XTR-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Xenopus tropicalis)
RHEA:67150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein] => L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2
RHEA:19187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA
RHEA:61833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sitosterol + UDP-alpha-D-glucose => H(+) + sitosteryl 3-beta-D-glucoside + UDP
REACT:R-HSA-3928583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates NMDAR2B (Homo sapiens)
RHEA:12341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] => H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)
REACT:R-CFA-6801766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Canis familiaris)
REACT:R-MMU-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)
REACT:R-RNO-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Rattus norvegicus)
REACT:R-HSA-917933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Homo sapiens)
RHEA:28288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine
RHEA:19045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)
REACT:R-HSA-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Homo sapiens)
REACT:R-DRE-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Danio rerio)
REACT:R-RNO-8956639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds YAP1 (Rattus norvegicus)
REACT:R-BTA-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Bos taurus)
REACT:R-DRE-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Danio rerio)
RHEA:44384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
EC:3.2.1.52	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-N-acetylhexosaminidase"
EC:3.2.1.52	skos:altLabel	"beta-hexosaminidase"
EC:3.2.1.52	skos:prefLabel	"beta-N-acetylhexosaminidase"
EC:3.2.1.52	skos:altLabel	"hexosaminidase"
EC:3.2.1.52	skos:altLabel	"N-acetyl-beta-glucosaminidase"
RHEA:61135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + kaempferol + succinate
RHEA:41726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0032840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular proline-rich region binding
GO:0032840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular proline-rich ligand binding
REACT:R-RNO-8848930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 translocates to the nucleus (Rattus norvegicus)
REACT:R-CFA-74715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of insulin receptor (Canis familiaris)
RHEA:18105	skos:altLabel	"Ca(2+)-transporting ATPase"
RHEA:18105	skos:prefLabel	"P-type Ca(2+) transporter"
RHEA:18105	skos:altLabel	"calcium pump"
RHEA:18105	skos:altLabel	"calcium-translocating P-type ATPase"
RHEA:18105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate
RHEA:18105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type Ca(2+) transporter"
RHEA:42479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2',3-trihydroxydiphenyl ether + H(+) + O2 <=> 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate
REACT:R-DME-376141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ABL with ROBO1:SLIT2 (Drosophila melanogaster)
RHEA:11900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH
RHEA:60639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(dodecanoyl)-sphing-4-enine-1-phosphocholine <=> choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate
REACT:R-DME-9008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylation (Drosophila melanogaster)
RHEA:21797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-rhamnose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH
GO:0102750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydrogeranylgeranyl-chlorophyll a reductase activity
REACT:R-HSA-1222431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxynitrite is reduced to nitrite by AhpC (Homo sapiens)
REACT:R-MMU-909719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STAT2 to p-IFNAR1 (Mus musculus)
REACT:R-GGA-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Gallus gallus)
REACT:R-MTU-879274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylglucosamine-inositol-phosphate is dephosphorylated (Mycobacterium tuberculosis)
RHEA:46356	skos:prefLabel	"long-chain fatty acid omega-monooxygenase"
RHEA:46356	skos:altLabel	"CYP704B1"
RHEA:46356	skos:altLabel	"CYP86A"
RHEA:46356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46356	skos:altLabel	"CYP4A"
RHEA:46356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain fatty acid omega-monooxygenase"
RHEA:46356	skos:altLabel	"CYP52M1"
RHEA:33435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fecosterol = episterol
RHEA:59457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetradecan-1-ol => H(+) + NADPH + tetradecanal
RHEA:33538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lanosteryl ester <=> a carboxylate + H(+) + lanosterol
REACT:R-SSC-5682863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF168 binds DNA DSBs (Sus scrofa)
REACT:R-HSA-5663156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds PPARA gene (Homo sapiens)
REACT:R-DME-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Drosophila melanogaster)
RHEA:57137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine
REACT:R-RNO-9690494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB translocates to the endosome membrane (Rattus norvegicus)
RHEA:47296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Homo sapiens)
REACT:R-SPO-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Schizosaccharomyces pombe)
REACT:R-DRE-9758674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 oxidizes PREDN,PREDL (Danio rerio)
REACT:R-SSC-8983374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Sus scrofa)
REACT:R-DRE-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Danio rerio)
REACT:R-MMU-8849068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARHGAP35 (Mus musculus)
REACT:R-RNO-8848414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds CDKN1B (Rattus norvegicus)
REACT:R-XTR-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Xenopus tropicalis)
REACT:R-CEL-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Caenorhabditis elegans)
REACT:R-GGA-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Gallus gallus)
RHEA:18778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkylmercury + H(+) => an alkane + Hg(2+)
REACT:R-MMU-5244669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Mus musculus)
REACT:R-DME-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Drosophila melanogaster)
RHEA:55564	skos:prefLabel	"4-hydroxytryptamine kinase"
RHEA:55564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxytryptamine kinase"
RHEA:55564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+)
REACT:R-DRE-2467811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of sister chromatids (Danio rerio)
REACT:R-MMU-2730863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 by PKC-theta (Mus musculus)
RHEA:52656	skos:prefLabel	"long-chain-3-hydroxyacyl-CoA dehydrogenase"
RHEA:52656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-3-hydroxyacyl-CoA dehydrogenase"
RHEA:52656	skos:altLabel	"beta-hydroxyacyl-CoA dehydrogenase"
RHEA:52656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH
RHEA:70651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]
RHEA:61590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + amicoumacin A 2-phosphate + H(+) => amicoumacin A + ATP
GO:0031891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 PACAP receptor binding
GO:0031891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 vasoactive intestinal polypeptide receptor binding
GO:0031891	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 vasoactive intestinal polypeptide receptor ligand
RHEA:30206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> 2 GDP + 2 H(+)
REACT:R-DRE-6809810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Danio rerio)
REACT:R-HSA-5693593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop extension by DNA polymerases (Homo sapiens)
REACT:R-CFA-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Canis familiaris)
RHEA:27838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-carbazole + H(+) + NADPH + O2 = 2'-aminobiphenyl-2,3-diol + NADP(+)
RHEA:27838	skos:prefLabel	"carbazole 1,9a-dioxygenase"
RHEA:27838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-carbazole + H(+) + NADH + O2 = 2'-aminobiphenyl-2,3-diol + NAD(+)
RHEA:27838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carbazole 1,9a-dioxygenase"
RHEA:27838	skos:altLabel	"CARDO"
RHEA:63884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-tyrosine peroxygenase"
RHEA:63884	skos:prefLabel	"L-tyrosine peroxygenase"
RHEA:63884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + L-tyrosine = H2O + L-dopa
RHEA:63409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-chloropyridine-2,3,5-triol + FADH2 + O2 => 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O
RHEA:65400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + butanoyl-CoA = butyl butanoate + CoA
RHEA:48702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol
REACT:R-DME-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Drosophila melanogaster)
REACT:R-XTR-3928627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB phosphorylates TIAM1 (Xenopus tropicalis)
REACT:R-SCE-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Saccharomyces cerevisiae)
REACT:R-SSC-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Sus scrofa)
REACT:R-SSC-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Sus scrofa)
REACT:R-GGA-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Gallus gallus)
RHEA:13479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-pyruvate + NADPH + NH4(+) => H2O + L-tryptophan + NADP(+)
GO:0061990	skos:prefLabel	"beta-ketodecanoyl-[acyl-carrier-protein] synthase"
GO:0061990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + octanoyl-CoA = 3-oxodecanoyl-[ACP] + CO2 + CoA
GO:0061990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-ketodecanoyl-[acyl-carrier-protein] synthase"
GO:0061990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ketodecanoyl-[acyl-carrier-protein] synthase activity
GO:0019156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoamylase activity
GO:0019156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen alpha-1,6-glucanohydrolase activity
GO:0019156	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	debranching enzyme activity
GO:0019156	skos:prefLabel	"isoamylase"
GO:0019156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoamylase"
GO:0019156	skos:altLabel	"debranching enzyme"
REACT:R-CFA-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Canis familiaris)
GO:0140871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	repressor of RNA polymerase inhibitor activity
RHEA:56095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-DRE-398040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma activation of PLC beta (Danio rerio)
RHEA:35618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyacetone + NAD(+) <=> H(+) + methylglyoxal + NADH
RHEA:69417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + thiocyanate => H2O + hypothiocyanous acid
RHEA:23227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-trans-zeatin + UDP
GO:0102139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity
RHEA:59595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-arginine <=> ADP + beta-alanyl-L-arginine + H(+) + phosphate
RHEA:48441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
REACT:R-HSA-391372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRH1,2 (Homo sapiens)
REACT:R-SSC-427337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBD2 binds methylcytosine in chromatin (Sus scrofa)
REACT:R-MMU-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Mus musculus)
REACT:R-BTA-77594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Bos taurus)
REACT:R-MMU-5687090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6 phosphorylates NCOA3 (Mus musculus)
RHEA:19860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16alpha-hydroxysteroid + NADP(+) <=> a 16-oxosteroid + H(+) + NADPH
REACT:R-HSA-9754839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 9b binds IKBKG (Homo sapiens)
REACT:R-HSA-1433374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processing of SCF isoform 1 (Homo sapiens)
RHEA:69032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dihydroxy-L-aspartate = (2S)-2-nitrosobutanedioate + H2O
RHEA:33658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate(out) <=> (9Z)-octadecenoate(in)
REACT:R-DRE-6784324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)
REACT:R-MMU-190256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to FGF (Mus musculus)
RHEA:46960	skos:prefLabel	"butanoyl-CoA dehydrogenase complex (NAD(+), ferredoxin)"
RHEA:46960	skos:altLabel	"bifurcating butanoyl-CoA dehydrogenase"
RHEA:46960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:46960	skos:altLabel	"butanoyl-CoA dehydrogenase/Etf complex"
RHEA:46960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"butanoyl-CoA dehydrogenase complex (NAD(+), ferredoxin)"
REACT:R-CFA-8871373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMX phosphorylates RUFY1 (Canis familiaris)
REACT:R-DRE-4551683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOPORS with SUMO1 (Danio rerio)
REACT:R-CEL-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Caenorhabditis elegans)
RHEA:39409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH
RHEA:15904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate <=> (2R)-3-phosphoglycerate
REACT:R-CEL-8949649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Caenorhabditis elegans)
REACT:R-XTR-9757954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4BP1 binds IKBKG (Xenopus tropicalis)
REACT:R-DRE-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Danio rerio)
RHEA:33092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate
REACT:R-MMU-8878054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 (Mus musculus)
REACT:R-GGA-5654407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates SHC1 (Gallus gallus)
GO:0030756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity
GO:0030756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoorientin 3'-methyltransferase activity
GO:0030756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoorientin 3'-O-methyltransferase activity
RHEA:62394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrolevoglucosan + H(+) + NADH => levoglucosan + NAD(+)
RHEA:10473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,3-dimethylmalate => propanoate + pyruvate
REACT:R-RNO-5694421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6 dephosphorylates SEC24 (Rattus norvegicus)
REACT:R-HSA-9603987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Homo sapiens)
EC:1.14.99.46	skos:prefLabel	"pyrimidine monooxygenase"
EC:1.14.99.46	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrimidine monooxygenase"
REACT:R-GGA-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Gallus gallus)
REACT:R-SSC-8853789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDNF,NRTN bind RET:GFRA1,GFRA2 (Sus scrofa)
REACT:R-BTA-9679028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 binds JAK3 inhibitors (Bos taurus)
REACT:R-HSA-2424484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BTK by p-SYK (Homo sapiens)
REACT:R-CEL-8875591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK7 activates RAC1 (Caenorhabditis elegans)
RHEA:14927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate + H(+) + NADPH => D-mannitol 1-phosphate + NADP(+)
GO:0033452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUG codon-amino acid adaptor activity
GO:0033452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine tRNA
GO:0033452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTG codon-amino acid adaptor activity
REACT:R-RNO-5649664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyG from damaged DNA (Rattus norvegicus)
REACT:R-SSC-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Sus scrofa)
REACT:R-HSA-936412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS (Homo sapiens)
RHEA:35466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + NAD(+) <=> 5alpha-cholest-7-en-3-one + H(+) + NADH
RHEA:48174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate => ganglioside GM2 + H2O
GO:0001162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
REACT:R-CFA-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)
REACT:R-HSA-8864729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2 (Homo sapiens)
REACT:R-DDI-5695957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Dictyostelium discoideum)
RHEA:33559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-3-phosphate 2-O-acyltransferase"
RHEA:33559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphate = a 2-acyl-sn-glycerol 3-phosphate + CoA
RHEA:33559	skos:altLabel	"sn-2-glycerol-3-phosphate O-acyltransferase"
RHEA:33559	skos:prefLabel	"glycerol-3-phosphate 2-O-acyltransferase"
RHEA:41746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol
REACT:R-CFA-193455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)
RHEA:54108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + guaia-4,6-diene
RHEA:54108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guaia-4,6-diene synthase"
RHEA:54108	skos:prefLabel	"guaia-4,6-diene synthase"
RHEA:31943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:38435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-HSA-9646383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynein motors transport misfolded proteins (Homo sapiens)
RHEA:53188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine
REACT:R-HSA-349657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)
RHEA:66069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + L-kynurenine => H2O + kynurenate + L-leucine
REACT:R-SSC-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Sus scrofa)
RHEA:44335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanine + L-anticapsin <=> ADP + bacilysin + H(+) + phosphate
REACT:R-MMU-5621347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG2 translocates from cytosol to plasma membrane (Mus musculus)
RHEA:26230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 NADP(+) + phytyl diphosphate => geranylgeranyl diphosphate + 3 H(+) + 3 NADPH
REACT:R-RNO-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Rattus norvegicus)
RHEA:37162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
REACT:R-GGA-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Gallus gallus)
RHEA:39394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)
REACT:R-CEL-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Caenorhabditis elegans)
RHEA:31000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => cucurbitadienol
RHEA:40593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + decanedioate + H(+) => decanedioyl-CoA + H2O
REACT:R-GGA-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Gallus gallus)
RHEA:63432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)
EC:1.1.1.378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-rhamnose 1-dehydrogenase [NAD(P)(+)]"
EC:1.1.1.378	skos:prefLabel	"L-rhamnose 1-dehydrogenase [NAD(P)(+)]"
RHEA:35174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + novobiocin(in) <=> H(+)(in) + novobiocin(out)
RHEA:15241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:15241	skos:altLabel	"CYP725A1"
RHEA:15241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taxane 10beta-hydroxylase"
RHEA:15241	skos:altLabel	"5-alpha-taxadienol-10-beta-hydroxylase"
RHEA:15241	skos:prefLabel	"taxane 10beta-hydroxylase"
REACT:R-CFA-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Canis familiaris)
REACT:R-DRE-427514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC deacetylates histone H3 (Danio rerio)
RHEA:18347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cis-alkene + CO2 => a cis-3-alkyl-4-alkyloxetan-2-one
REACT:R-HSA-3149454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)
REACT:R-HSA-9665696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)
REACT:R-DDI-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
RHEA:35869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-HSA-2106591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD stimulates transcription of SMAD7 (Homo sapiens)
RHEA:58911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH <=> C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)
GO:0102416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin gentiotrioside 1,6-glucosyltransferase activity
RHEA:37404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA
REACT:R-BTA-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Bos taurus)
REACT:R-DRE-176101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Rad17-RFC complex to DNA (Danio rerio)
REACT:R-HSA-141422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 converted  to an inhibitory state via interaction with Mad1 (Homo sapiens)
RHEA:58886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chloramphenicol + 2 H2O => AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2
REACT:R-MMU-429663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-RNO-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Rattus norvegicus)
RHEA:11654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose
RHEA:48679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0070524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0070524	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-hydroxysteroid dehydrogenase
GO:0070524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	corticosteroid 11-beta-dehydrogenase activity
REACT:R-DRE-6786124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3,STAT6 bind p-Y-IL4R (Danio rerio)
REACT:R-CFA-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Canis familiaris)
RHEA:23177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + CoA => acetyl-CoA + AMP + diphosphate
REACT:R-HSA-2467436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)
RHEA:49275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5654614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)
REACT:R-SPO-1482827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Schizosaccharomyces pombe)
REACT:R-RNO-216082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaXbeta2 with fibrin (Rattus norvegicus)
REACT:R-SSC-9614423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO1 (Sus scrofa)
RHEA:43958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate => 15-methylhexadecanoate + H(+) + NADPH + O2
RHEA:18398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Glx) => AMP + diphosphate + L-glutamyl-tRNA(Glx)
REACT:R-XTR-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Xenopus tropicalis)
REACT:R-SSC-8853793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET complexes bind GRB2 (Sus scrofa)
RHEA:47992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"proton-translocating NAD(P)(+) transhydrogenase"
RHEA:47992	skos:prefLabel	"proton-translocating NAD(P)(+) transhydrogenase"
RHEA:47992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)
REACT:R-HSA-9749286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds MCM2-7 (Homo sapiens)
GO:0016936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactoside binding
REACT:R-RNO-6810843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin binds periplakin (Rattus norvegicus)
REACT:R-RNO-8950731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:IL27 translocates to the extracellular region (Rattus norvegicus)
REACT:R-HSA-5694435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)
GO:0080016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-E-beta-caryophyllene synthase activity
RHEA:20450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 => 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)
REACT:R-CFA-192178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
REACT:R-CEL-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Caenorhabditis elegans)
RHEA:48854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2
RHEA:11470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-valine
REACT:R-HSA-873927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of STAT1 dimer from active receptor unit (Homo sapiens)
REACT:R-RNO-9626928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP binds FOXO1 (Rattus norvegicus)
RHEA:40125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:60773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 => 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate
RHEA:28487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(in) => Fe(2+)(out)
GO:0015117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate transmembrane transporter activity
GO:0015117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate(in) = thiosulfate(out)
GO:0015117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulphate transporter activity
GO:0015117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate permease activity
RHEA:43794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(645) in 25S rRNA + S-adenosyl-L-methionine
REACT:R-RNO-6804942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 homodimers auto-ubiquitinate (Rattus norvegicus)
RHEA:62467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-CEL-2022887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 N-deacetylates GlcNAc residues in heparan (Caenorhabditis elegans)
RHEA:61072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-(R)-19-hydroxytabersonine + acetyl-CoA = (-)-(R)-19-O-acetyltabersonine + CoA
REACT:R-HSA-5684875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)
REACT:R-CFA-112042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid binds MOR (Canis familiaris)
REACT:R-SSC-6786095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates STAT3,STAT6 (Sus scrofa)
REACT:R-XTR-6799197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Xenopus tropicalis)
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:NADP+ oxidoreductase activity
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione reductase activity
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-GSSG reductase activity
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-glutathione reductase activity
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidized glutathione reduction
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GSSG reductase activity
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:oxidized-glutathione oxidoreductase activity
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione S-reductase activity
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-disulphide reductase activity
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GSH reductase activity
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-disulfide reductase activity
GO:0004362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-disulfide reductase (NADPH) activity
REACT:R-BTA-936390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD mediated deubiquitination of DDX58 (RIG-I) (Bos taurus)
RHEA:14832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-acetyl-L-serine <=> acetate + L-cysteine
REACT:R-GGA-445699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Gallus gallus)
RHEA:28786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinylglycine <=> glycine + L-cysteine
REACT:R-CFA-8951486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C4b (Canis familiaris)
REACT:R-RNO-210285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homophilic interaction of PECAM-1 (Rattus norvegicus)
REACT:R-MMU-8873923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 binds LPCAT1 and PC (Mus musculus)
GO:0030284	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	estrogen receptor activity
GO:0030284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear estrogen receptor activity
REACT:R-HSA-450259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex (Homo sapiens)
REACT:R-DRE-8981606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin binds oxygen (Danio rerio)
RHEA:60732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + perillyl aldehyde = 2 H(+) + NADPH + perillate
REACT:R-HSA-9755244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 (Homo sapiens)
REACT:R-CFA-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Canis familiaris)
GO:0036042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acyl-CoA binding
GO:0036042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acyl-coenyme A binding
REACT:R-XTR-1676020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Xenopus tropicalis)
REACT:R-BTA-389995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Bos taurus)
REACT:R-SSC-9009541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds to TFF1 gene promoter (Sus scrofa)
RHEA:20716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine
RHEA:20716	skos:prefLabel	"S-adenosylhomocysteine deaminase"
RHEA:20716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-adenosylhomocysteine deaminase"
GO:0140835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain T4 kinase activity
RHEA:13799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,poly-cis-dolichol + phosphate => a dolichyl phosphate + H2O
RHEA:54673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-kolavenyl diphosphate + H2O => (+)-kolavelool + diphosphate
RHEA:40772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg1 + H2O => (20S)-ginsenoside F1 + D-glucose
REACT:R-RNO-83660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-anchored TNF-α binds TNFR1 (Rattus norvegicus)
GO:0048406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neurotrophin TRKA receptor activity
GO:0048406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nerve growth factor binding
GO:0048406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nerve growth factor binding
GO:0048406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	filamin-3 binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ABP-280 binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-filamin binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gamma-filamin binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	filamin A binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ABPL binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ABP-278/276 binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	filamin-1 binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	filamin-C binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	filamin-2 binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	filamin-A binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-filamin binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	filamin B binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	filamin C binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	filamin binding
GO:0031005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	filamin-B binding
REACT:R-MMU-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Mus musculus)
REACT:R-RNO-9709454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR binds EPOR agonists (Rattus norvegicus)
REACT:R-SSC-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Sus scrofa)
RHEA:38815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine
RHEA:71506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)
REACT:R-BTA-74715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of insulin receptor (Bos taurus)
RHEA:11562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + CO2 + NADH => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)
RHEA:68776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = diphosphate + germacrene A
REACT:R-DDI-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Dictyostelium discoideum)
RHEA:38354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH
RHEA:27410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a menaquinone + protoporphyrinogen IX => 3 a menaquinol + protoporphyrin IX
RHEA:41758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2
RHEA:65972	skos:prefLabel	"ABC-type antigen peptide transporter"
RHEA:65972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + H(+) + phosphate
RHEA:65972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type antigen peptide transporter"
RHEA:36708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-ureido-L-serine => O-ureido-D-serine
GO:0015090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity iron transporter activity
GO:0015090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity iron ion transmembrane transporter activity
GO:0015090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity ferric iron ion transmembrane transporter activity
REACT:R-PFA-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Plasmodium falciparum)
RHEA:67855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + O2 <=> FMN-N(5)-peroxide
RHEA:15927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bunolol + H(+) + NADPH => dihydrobunolol + NADP(+)
REACT:R-CFA-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Canis familiaris)
REACT:R-SPO-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Schizosaccharomyces pombe)
RHEA:47205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8938121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds CTSK (Homo sapiens)
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6,7-dihydropteridine:NAD(P)H oxidoreductase activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydropteridine reductase activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dihydropteridine reductase activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHPR activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H2:6,7-dihydropteridine oxidoreductase activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydropteridine reduction
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,7-dihydropteridine reductase activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-specific dihydropteridine reductase activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydropteridine reductase (NADH) activity
GO:0004155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dihydropteridine reductase activity
RHEA:59421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylamine + O2 => formaldehyde + H2O2 + NH4(+)
REACT:R-XTR-70679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 oxidises L-GluSS to Glu (Xenopus tropicalis)
RHEA:42363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allulose <=> keto-D-fructose
REACT:R-BTA-190261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3c binds to FGF (Bos taurus)
RHEA:38787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-SSC-352029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Sus scrofa)
REACT:R-BTA-8936851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHRR binds ARNT (Bos taurus)
REACT:R-HSA-9014652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
REACT:R-RNO-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Rattus norvegicus)
REACT:R-SSC-5686685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Sus scrofa)
RHEA:57044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apionate + NAD(+) = 3-oxoisoapionate + H(+) + NADH
RHEA:57044	skos:prefLabel	"D-apionate oxidoisomerase"
RHEA:57044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-apionate oxidoisomerase"
REACT:R-HSA-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Homo sapiens)
RHEA:72523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-8863914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
RHEA:66242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + IC-asc-C9-CoA => ATP + CoA + IC-asc-C9
REACT:R-CFA-374701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DCC by Fyn (Canis familiaris)
REACT:R-DRE-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Danio rerio)
RHEA:35743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + versicolorin B = 2 H2O + NADP(+) + versicolorin A
RHEA:35743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"versicolorin B desaturase"
RHEA:35743	skos:prefLabel	"versicolorin B desaturase"
RHEA:19508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose <=> (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP
REACT:R-RNO-158333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Rattus norvegicus)
REACT:R-SSC-8983384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Sus scrofa)
RHEA:24761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-dopa + NADH => 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)
REACT:R-HSA-373711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Netrin-1 (Homo sapiens)
REACT:R-RNO-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
RHEA:71276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurolithocholate 3-sulfate(out) => 2 Na(+)(in) + taurolithocholate 3-sulfate(in)
REACT:R-BTA-6786072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3,p-Y641-STAT6 dissociate (Bos taurus)
REACT:R-BTA-6798474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Zn2+ (Bos taurus)
REACT:R-DRE-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Danio rerio)
REACT:R-HSA-6800001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members stimulate FAS gene expression (Homo sapiens)
EC:4.6.1.-	skos:prefLabel	"Phosphorus-oxygen lyases"
EC:4.6.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphorus-oxygen lyases"
REACT:R-DRE-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Danio rerio)
REACT:R-DDI-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Dictyostelium discoideum)
REACT:R-DDI-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Dictyostelium discoideum)
REACT:R-RNO-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Rattus norvegicus)
REACT:R-RNO-6804955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDM2 (Rattus norvegicus)
REACT:R-HSA-349603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Homo sapiens)
REACT:R-SCE-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Saccharomyces cerevisiae)
REACT:R-XTR-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Xenopus tropicalis)
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diprenyltransferase activity
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2E,6E)-farnesyl diphosphate synthetase activity
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-diphosphate synthase activity
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl pyrophosphate synthetase activity
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyltranstransferase activity
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DMAPP:IPP-dimethylallyltransferase activity
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyltransferase activity
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-farnesyl pyrophosphate synthetase activity
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl pyrophosphate synthase activity
GO:0004161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranyl diphosphate synthase
REACT:R-XTR-177937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of EGFR by SRC kinase (Xenopus tropicalis)
REACT:R-MMU-879930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 is recruited by JAK2 (Mus musculus)
REACT:R-HSA-8854612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 accelerates GTP hydrolysis by RAB33B (Homo sapiens)
RHEA:15386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine => 3-cyano-L-alanine + H2O
EC:1.14.12.23	skos:prefLabel	"nitroarene dioxygenase"
EC:1.14.12.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitroarene dioxygenase"
REACT:R-SSC-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Sus scrofa)
REACT:R-SSC-5653936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Ragulator complex (Sus scrofa)
REACT:R-DRE-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Danio rerio)
RHEA:41369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)
REACT:R-CFA-110356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MPG glycosylase by APEX1 at the AP site (Canis familiaris)
RHEA:42164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O
REACT:R-DDI-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Dictyostelium discoideum)
REACT:R-BTA-5685985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Bos taurus)
RHEA:53673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O
RHEA:66197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + tryptamine => CoA + H(+) + N-acetyltryptamine
RHEA:24388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + uridine = alpha-D-ribose 1-phosphate + uracil
REACT:R-MMU-3788061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by ADAM8 (Mus musculus)
GO:0140348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophosphatidylcholine flippase activity (exoplasmic to cytosolic leaftlet)
GO:0140348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophosphatidylcholine flippase activity
REACT:R-BTA-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Bos taurus)
RHEA:45668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-PFA-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Plasmodium falciparum)
RHEA:56818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine nucleobase + D-ribose => a pyrimidine ribonucleoside + H2O
RHEA:67560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + taurocholate = adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate
REACT:R-SSC-1855169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)
REACT:R-RNO-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Rattus norvegicus)
REACT:R-HSA-4085133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUM (lumican) binds integrin alpha2beta1 (Homo sapiens)
REACT:R-MMU-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Mus musculus)
RHEA:19876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate + H2O <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate
REACT:R-BTA-5626549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind CALM1 (Bos taurus)
REACT:R-RNO-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Rattus norvegicus)
RHEA:60341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-GGA-140840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Gallus gallus)
REACT:R-SPO-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Schizosaccharomyces pombe)
REACT:R-BTA-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Bos taurus)
RHEA:43652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + CoA
RHEA:50805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin J2 => prostaglandin J2-S-(R)-glutathione
REACT:R-CEL-8874082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates PTK2 (Caenorhabditis elegans)
REACT:R-SSC-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Sus scrofa)
RHEA:61289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-ribose + ATP => 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)
GO:0106340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (guanosine 32-2'-O)-methyltransferase activity
RHEA:21841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
REACT:R-MMU-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Mus musculus)
REACT:R-SSC-177943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to EGF:EGFR complex (Sus scrofa)
RHEA:58973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + vanillin => H(+) + H2O2 + vanillate
REACT:R-PFA-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Plasmodium falciparum)
REACT:R-XTR-5696914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP28 deubiquitinates CLSPN and MYC (Xenopus tropicalis)
RHEA:66821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mn(2+)(in) => ADP + H(+) + Mn(2+)(out) + phosphate
REACT:R-BTA-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Bos taurus)
REACT:R-CFA-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Canis familiaris)
REACT:R-XTR-2028644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Xenopus tropicalis)
REACT:R-XTR-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Xenopus tropicalis)
RHEA:14804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + ATP <=> (2R)-3-phospho-glyceroyl phosphate + ADP
RHEA:37464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
RHEA:62168	skos:altLabel	"diacetylchitobiose deacetylase"
RHEA:62168	skos:prefLabel	"N,N'-diacetylchitobiose non-reducing end deacetylase"
RHEA:62168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiose = acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine
RHEA:62168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N,N'-diacetylchitobiose non-reducing end deacetylase"
REACT:R-MMU-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Mus musculus)
RHEA:50127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D1 <=> 8-oxoresolvin D1 + H(+) + NADH
REACT:R-BTA-83788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to Type 2 promoter (Bos taurus)
REACT:R-DDI-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Dictyostelium discoideum)
RHEA:39247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z)-eicosenoyl-CoA = (2E,11Z)-eicosadienoyl-CoA + H2O
RHEA:57959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + H(+) + NADH + O2 <=> dimethyl sulfone + H2O + NAD(+)
RHEA:16689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + H2O = D-glucose + phosphate
EC:3.1.13.5	skos:prefLabel	"ribonuclease D"
EC:3.1.13.5	skos:altLabel	"RNase D"
EC:3.1.13.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease D"
RHEA:41557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate
REACT:R-HSA-1112666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
REACT:R-XTR-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Xenopus tropicalis)
REACT:R-SSC-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Sus scrofa)
REACT:R-BTA-9027302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)
REACT:R-HSA-3139027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Maturation of HIV Virion (Homo sapiens)
RHEA:71928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauroursodeoxycholate(out) => 2 Na(+)(in) + tauroursodeoxycholate(in)
RHEA:56575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose <=> globoside Gb3Cer + H(+) + UDP
REACT:R-BTA-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Bos taurus)
REACT:R-XTR-388811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-1 homodimer (Xenopus tropicalis)
RHEA:22821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP
REACT:R-BTA-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Bos taurus)
REACT:R-CFA-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Canis familiaris)
RHEA:50810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin J2-S-(S)-glutathione => glutathione + prostaglandin J2
REACT:R-HSA-6786190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMBL hydrolyses OM to OLMS (Homo sapiens)
REACT:R-HSA-112266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Homo sapiens)
REACT:R-DDI-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Dictyostelium discoideum)
RHEA:62229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ascladiol + A => AH2 + patulin
REACT:R-CFA-1295632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA2A dephosphorylates SPRY2 (Canis familiaris)
RHEA:41706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O
RHEA:58101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(15Z-tetracosenoyl)-glycerol + H2O => (15Z)-tetracosenoate + glycerol + H(+)
REACT:R-RNO-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Rattus norvegicus)
REACT:R-GGA-392053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS binds Grb2 bound to pFAK:NCAM1 (Gallus gallus)
RHEA:50323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:1.3.3.-	skos:prefLabel	"With oxygen as acceptor"
EC:1.3.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
RHEA:20440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5D-5-O-methyl-chiro-inositol + NADP(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH
RHEA:47477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA
RHEA:30033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis,cis-muconate + H(+) => (S)-muconolactone
RHEA:34512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP
GO:0008073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine decarboxylase inhibitor activity
REACT:R-MMU-8869603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A13 transports NCA from extracellular region to cytosol (Mus musculus)
REACT:R-SCE-5674496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate MAP2K1 (Saccharomyces cerevisiae)
RHEA:67986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-leucine => N-acetyl-L-leucine
REACT:R-DDI-76416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Benzene is hydroxylated to phenol (Dictyostelium discoideum)
REACT:R-DME-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)
GO:0090684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	contact chemosensation receptor activity
GO:0090684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	contact chemoreceptor activity
REACT:R-DRE-9009536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX5 binds ESR1:estrogen:TFF1 gene promoter (Danio rerio)
RHEA:63892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-tryptophan = AMP + D-tryptophan + diphosphate + H(+)
REACT:R-BTA-202724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-selectin binds P-selectin ligand (Bos taurus)
REACT:R-GGA-417114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of telomerase RNP (Gallus gallus)
REACT:R-SSC-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Sus scrofa)
REACT:R-SSC-9691174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the ER membrane (Sus scrofa)
RHEA:17920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Glu(-Cys)](n)-Gly + glutathione + H(+) <=> [Glu(-Cys)](n+1)-Gly + glycine
REACT:R-RNO-9020282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Rattus norvegicus)
RHEA:35490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
REACT:R-BTA-2428926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Bos taurus)
REACT:R-PFA-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Plasmodium falciparum)
RHEA:61175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP
GO:0070594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juvenile hormone response element binding
GO:0070594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JHRE binding
RHEA:47331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)
RHEA:61106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-163010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Down Regulation of Emi1 through Phosphorylation of Emi1 (Canis familiaris)
REACT:R-DME-2066780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)
REACT:R-XTR-390912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds hist (Xenopus tropicalis)
REACT:R-CEL-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Caenorhabditis elegans)
REACT:R-HSA-205118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 polyubiquitinates NRIF (Homo sapiens)
RHEA:56756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:61567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tetracycline + H(+) + NADPH + O2 <=> a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)
RHEA:66275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate
REACT:R-MMU-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Mus musculus)
REACT:R-MMU-8855617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Mus musculus)
EC:3.4.24.87	skos:altLabel	"ADAMTS VWF cleaving metalloprotease"
EC:3.4.24.87	skos:altLabel	"Upshaw factor"
EC:3.4.24.87	skos:altLabel	"vWF-degrading protease"
EC:3.4.24.87	skos:altLabel	"von Willebrand factor cleaving protease"
EC:3.4.24.87	skos:altLabel	"ADAMTS13 peptidase"
EC:3.4.24.87	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADAMTS13 endopeptidase"
EC:3.4.24.87	skos:altLabel	"vWF-cleaving protease"
EC:3.4.24.87	skos:prefLabel	"ADAMTS13 endopeptidase"
REACT:R-DRE-9024766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Danio rerio)
REACT:R-MMU-6786239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)
REACT:R-MMU-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Mus musculus)
RHEA:51081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:3.2.1.207	skos:prefLabel	"mannosyl-oligosaccharide alpha-1,3-glucosidase"
EC:3.2.1.207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosyl-oligosaccharide alpha-1,3-glucosidase"
EC:3.2.1.207	skos:altLabel	"ER glucosidase II"
EC:3.2.1.207	skos:altLabel	"alpha-glucosidase II"
EC:3.2.1.207	skos:altLabel	"trimming glucosidase II"
RHEA:51174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine
GO:0008941	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NOD activity
GO:0008941	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitric oxide,NAD(P)H:oxygen oxidoreductase activity
GO:0008941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide dioxygenase activity
REACT:R-CFA-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Canis familiaris)
REACT:R-SSC-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Sus scrofa)
REACT:R-XTR-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Xenopus tropicalis)
RHEA:52302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:71329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-threonine(in) + 2 Na(+)(in) => chloride(out) + L-threonine(out) + 2 Na(+)(out)
RHEA:37010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA
RHEA:45605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)
RHEA:37535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-HSA-2029449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SYK by Src kinases (Homo sapiens)
REACT:R-CFA-6786070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Canis familiaris)
REACT:R-DRE-9667914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand midkine (MDK) (Danio rerio)
REACT:R-HSA-6803411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCBP4 modulates CDKN1A translation (Homo sapiens)
REACT:R-MMU-2533950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP14, TMPRSS6 (Mus musculus)
REACT:R-XTR-5666197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds LIN7B (Xenopus tropicalis)
RHEA:27977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxy-5,6,7,8-tetrahydropterin + H(+) <=> 7-carboxy-7-deazaguanine + NH4(+)
REACT:R-SSC-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Sus scrofa)
RHEA:47767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(1369) in 16S rRNA <=> 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
GO:0008972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphomethylpyrimidine kinase activity
GO:0008972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity
GO:0008972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylpyrimidine phosphokinase activity
REACT:R-CEL-8964604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Caenorhabditis elegans)
REACT:R-BTA-6809254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR8 binds MTMR9 (Bos taurus)
RHEA:50306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]
RHEA:65432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)
REACT:R-HSA-9023345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 gene expression is inhibited by MECP2 (Homo sapiens)
RHEA:71386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(in) + Na(+)(in) <=> L-asparagine(out) + Na(+)(out)
REACT:R-BTA-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Bos taurus)
RHEA:71938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate(out) + 2 Na(+)(out) <=> glycocholate(in) + 2 Na(+)(in)
REACT:R-SSC-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Sus scrofa)
REACT:R-MMU-8937767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 dephosphorylates RUNX1 (Mus musculus)
REACT:R-DDI-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Dictyostelium discoideum)
RHEA:51678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + 2 AH2 + H(+) + sulfite => [protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide
REACT:R-DRE-8944223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type V (Danio rerio)
RHEA:19835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + formate + H(+) => (6S)-10-formyltetrahydrofolate + H2O
GO:0080067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity
RHEA:29508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-alpha-gurjunene + diphosphate
REACT:R-DDI-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Dictyostelium discoideum)
REACT:R-GGA-5668414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Gallus gallus)
REACT:R-CFA-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Canis familiaris)
REACT:R-RNO-4641253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 ubiquitinates FZD to promote its downregulation (Rattus norvegicus)
REACT:R-SPO-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Schizosaccharomyces pombe)
RHEA:57817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + H2O => 2-deoxy-D-ribose 5-phosphate + guanine
REACT:R-RNO-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Rattus norvegicus)
RHEA:49305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine
RHEA:15331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-carbamoyl-2-oxoglycine + NADH => (S)-ureidoglycolate + NAD(+)
RHEA:38165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA
REACT:R-CFA-9647632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDME (Canis familiaris)
GO:0008484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfuric ester hydrolase activity
GO:0008484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfatase activity
GO:0008484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphuric ester hydrolase activity
REACT:R-CFA-9710353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds cardiolipin (Canis familiaris)
RHEA:30182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-HSA-9682603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)
RHEA:66580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + bisphenol A = adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)
REACT:R-SSC-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Sus scrofa)
RHEA:70337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-L-lyxonate + H(+) => 2-carboxy-L-lyxonolactone + H2O
REACT:R-CFA-5607741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p52:RELB translocates from cytosol to nucleus (Canis familiaris)
RHEA:64324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA
REACT:R-CFA-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Canis familiaris)
RHEA:40970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)
REACT:R-HSA-2471660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective OPN1LW causes CBP (Homo sapiens)
REACT:R-HSA-5690046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT2 hydrolyses PALMCoA to PALM (Homo sapiens)
RHEA:43607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]
RHEA:29365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + phosphate => dCMP + H2O
REACT:R-HSA-5687083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYC binds MAPKAPK5 gene (Homo sapiens)
RHEA:50569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]
RHEA:55995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
REACT:R-DRE-9020261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Danio rerio)
RHEA:12174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + NH4(+) => alpha-D-glucosamine 6-phosphate + H2O
RHEA:50951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in single-stranded DNA + NH4(+)
RHEA:16066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + phytanoyl-CoA => 2-hydroxyphytanoyl-CoA + CO2 + succinate
RHEA:12515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate + H2O + O2 <=> H2O2 + NH4(+) + oxaloacetate
REACT:R-CFA-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)
RHEA:69349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-1-propenyl-L-cysteine sulfoxide => (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate
REACT:R-XTR-201486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand pleiotrophin (PTN) (Xenopus tropicalis)
RHEA:45435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate
REACT:R-DRE-9020275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DHA to 17(S)-Hp-DHA (Danio rerio)
REACT:R-GGA-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)
REACT:R-RNO-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Rattus norvegicus)
REACT:R-HSA-9670431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated KIT mutants bind PI3K (Homo sapiens)
REACT:R-CFA-6788392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Canis familiaris)
REACT:R-CFA-203716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1 complex binds to Nostrin (Canis familiaris)
REACT:R-XTR-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Xenopus tropicalis)
REACT:R-DRE-113402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:early elongation complex (Danio rerio)
REACT:R-BTA-352108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Bos taurus)
REACT:R-HSA-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
REACT:R-DRE-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Danio rerio)
REACT:R-HSA-9023159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87)) (Homo sapiens)
REACT:R-CFA-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Canis familiaris)
REACT:R-SSC-2395801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LAT by p-SYK (Sus scrofa)
RHEA:69492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octan-1-ol = H2O2 + octanal
REACT:R-RNO-8950183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B binds IL23A (Rattus norvegicus)
RHEA:55453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Rattus norvegicus)
REACT:R-HSA-165777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4B by activated S6K1 (Homo sapiens)
RHEA:36310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + H2O <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA
REACT:R-BTA-5634103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 dissociates from atRA:RAR:RXR (Bos taurus)
REACT:R-MMU-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acylcholine + H2O = a carboxylate + choline + H(+)
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholinesterase"
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoylcholinesterase activity
GO:0004104	skos:altLabel	"non-specific cholinesterase"
GO:0004104	skos:altLabel	"acylcholine acylhydrolase"
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline esterase activity
GO:0004104	skos:prefLabel	"cholinesterase"
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BtChoEase activity
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pseudocholinesterase activity
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyrylcholine esterase activity
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anticholineesterase activity
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholinesterase activity
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylcholine acylhydrolase activity
GO:0004104	skos:altLabel	"pseudocholinesterase"
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	non-specific cholinesterase activity
GO:0004104	skos:altLabel	"butyrylcholine esterase"
GO:0004104	skos:altLabel	"choline esterase II (unspecific)"
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyrylcholinesterase activity
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionylcholinesterase activity
GO:0004104	skos:altLabel	"benzoylcholinesterase"
GO:0004104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline esterase II (unspecific) activity
RHEA:71404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] => 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:52542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate + cytosine => cytidine + phosphate
RHEA:17992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[protein] <=> ADP + H(+) + O-phospho-L-seryl-[protein]
RHEA:59982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGDP + H(+) + phosphate => 8-oxo-dGTP + H2O
REACT:R-RNO-420131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PACAP receptor binds PACAP (Rattus norvegicus)
REACT:R-SSC-164834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enzyme-bound ATP is released (Sus scrofa)
RHEA:29936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine(in) + H(+)(in) => cytosine(out) + H(+)(out)
REACT:R-CEL-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Caenorhabditis elegans)
RHEA:38889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoate + sphinganine => H2O + N-hexanoyl-sphinganine
REACT:R-DME-1250380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Drosophila melanogaster)
REACT:R-BTA-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Bos taurus)
GO:0090432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA ligase activity
GO:0090432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA synthetase activity
RHEA:11022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP
REACT:R-SSC-77590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CstF to the CPSF Bound Pre-mRNA (Sus scrofa)
REACT:R-HSA-8951442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter (Homo sapiens)
REACT:R-GGA-1369028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid efflux (Gallus gallus)
RHEA:58705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin hemiaminal => rifampicin ortho-naphthoquinone carboxamide
RHEA:40079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-444705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R1/T1R3 dimer is the umami taste receptor (Sus scrofa)
RHEA:67757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
RHEA:51733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glandicoline B + S-adenosyl-L-methionine => H(+) + meleagrin + S-adenosyl-L-homocysteine
REACT:R-SSC-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Sus scrofa)
REACT:R-MMU-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Mus musculus)
REACT:R-SSC-1964496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds TRIM32 or TRIM56  (Sus scrofa)
RHEA:35467	skos:altLabel	"dimethylsulfoniopropionate-dependent demethylase A"
RHEA:35467	skos:prefLabel	"dimethylsulfoniopropionate demethylase"
RHEA:35467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)
RHEA:35467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylsulfoniopropionate demethylase"
REACT:R-CEL-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Caenorhabditis elegans)
RHEA:59599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynuramine + O2 <=> 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)
RHEA:43921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Xenopus tropicalis)
RHEA:57704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH
REACT:R-BTA-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Bos taurus)
REACT:R-DRE-114252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-3 by the apoptosome (Danio rerio)
REACT:R-HSA-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Homo sapiens)
RHEA:37646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:34161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + UDP-N,N'-diacetylbacillosamine => acetyl-CoA + UDP-N-acetylbacillosamine
RHEA:52925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-MMU-203774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Csk with PAG (Mus musculus)
RHEA:53728	skos:prefLabel	"N-acetyl-D-muramate 6-phosphate phosphatase"
RHEA:53728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyl-D-muramate 6-phosphate phosphatase"
RHEA:53728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-muramate 6-phosphate = N-acetyl-D-muramate + phosphate
REACT:R-CFA-432164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Canis familiaris)
REACT:R-MMU-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Mus musculus)
REACT:R-CFA-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Canis familiaris)
REACT:R-DDI-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Dictyostelium discoideum)
REACT:R-RNO-5672083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KTN1 binds Kinesin-1 (Rattus norvegicus)
RHEA:45646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-hexadecanoylsphing-4-enine + phosphocholine => H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine
REACT:R-XTR-388981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Kiss receptor GPR54 binds kisspeptin (Xenopus tropicalis)
RHEA:56944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + D-ribulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + H2O
RHEA:44548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Drosophila melanogaster)
RHEA:72084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-beta-D-ribose 1'',2''-cyclic phosphate + H2O => ADP-beta-D-ribose 1''-phosphate + H(+)
RHEA:37712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
RHEA:67517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:62237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine(6-4)cytidine in DNA => a cytidine dimer in DNA + H(+)
REACT:R-SPO-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Schizosaccharomyces pombe)
REACT:R-XTR-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Xenopus tropicalis)
REACT:R-CEL-109343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Caenorhabditis elegans)
REACT:R-HSA-212380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TRAP coactivator complex (Homo sapiens)
REACT:R-SSC-8854222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D3 associates with RAB5 (Sus scrofa)
RHEA:46331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-3-phenylserine <=> 3-phenylpyruvate + NH4(+)
RHEA:15996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ARK 2
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 in ADRB2:GRK complex is phosphorylated (Homo sapiens)
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-adrenergic-receptor kinase activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-AR kinase activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP:beta-adrenergic-receptor phosphotransferase activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-adrenoceptor kinase activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADRBK1
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	adrenergic receptor kinase activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-adrenergic receptor kinase activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-adrenoceptor kinase 2 activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta2ARK
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GRK2
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-adrenergic-receptor kinase (phosphorylating) activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-receptor kinase activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ARK 1
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	betaARK1
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BARK1
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[b-adrenergic-receptor] kinase activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GRK3
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ARK
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK15
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-adrenergic receptor-specific kinase activity
GO:0047696	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-adrenoceptor kinase 1 activity
REACT:R-DRE-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Danio rerio)
REACT:R-RNO-2682349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Rattus norvegicus)
RHEA:64141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-asparagine + H2O => a fatty acid + L-asparagine
RHEA:28535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP + H2O => diphosphate + dTMP + H(+)
REACT:R-DME-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Drosophila melanogaster)
GO:0030110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLA-C specific inhibitory MHC class I receptor activity
GO:0047086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ketosteroid monooxygenase activity
GO:0047086	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)
GO:0047086	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)
GO:0047086	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)
GO:0047086	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)
GO:0047086	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid-ketone monooxygenase activity
REACT:R-BTA-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Bos taurus)
REACT:R-XTR-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Xenopus tropicalis)
RHEA:68139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetophenone + H(+) + NADPH <=> (R)-1-phenylethanol + NADP(+)
REACT:R-HSA-199929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 activates the transcription factor MEF2 (Homo sapiens)
REACT:R-DME-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Drosophila melanogaster)
REACT:R-XTR-8854222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D3 associates with RAB5 (Xenopus tropicalis)
RHEA:23337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O2 + 2 iodide => diiodine + 2 H2O
RHEA:11386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxooctadecanoate + H(+) + NADH => (S)-2-hydroxyoctadecanoate + NAD(+)
GO:0050585	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	4-hydroxyphenylpyruvate dioxygenase II activity
GO:0050585	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
GO:0050585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxymandelate synthase activity
RHEA:43605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]
REACT:R-DRE-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Danio rerio)
RHEA:30334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-5602295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F22 20-hydroxylates TrXA3 (Sus scrofa)
REACT:R-CFA-174238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Canis familiaris)
REACT:R-RNO-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Rattus norvegicus)
RHEA:50144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (9Z)-hexadecenoate + H2O = (9Z)-hexadecenoate + ethanol + H(+)
REACT:R-MMU-8874202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the cytosol to the nucleus (Mus musculus)
REACT:R-DDI-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Dictyostelium discoideum)
REACT:R-DME-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)
RHEA:36970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA
REACT:R-DRE-2468041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Danio rerio)
REACT:R-CFA-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Canis familiaris)
REACT:R-DRE-8964634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Danio rerio)
RHEA:23750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + pppGp(2'-5')A => ATP + GTP
REACT:R-HSA-3321883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSL acetylates histone H4 (Homo sapiens)
RHEA:69376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydodecanoate + O2 = 2-oxododecanoate + H2O2
REACT:R-MMU-5610723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind SUFU (Mus musculus)
REACT:R-CFA-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)
GO:0005289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity arginine transmembrane transporter activity
GO:0005289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity L-arginine transmembrane transporter activity
GO:0005289	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	high-affinity arginine transporter activity
GO:0005289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity arginine transmembrane transporter activity
RHEA:40857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + trans-2-undecenoyl-CoA => FAD + H(+) + undecanoyl-CoA
REACT:R-XTR-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Xenopus tropicalis)
RHEA:57604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Bos taurus)
REACT:R-BTA-2130478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of invariant chain trimer and MHC II alpha beta dimer (Bos taurus)
REACT:R-RNO-1614654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Rattus norvegicus)
REACT:R-HSA-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-DDI-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Dictyostelium discoideum)
REACT:R-GGA-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Gallus gallus)
REACT:R-MMU-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Mus musculus)
REACT:R-SSC-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Sus scrofa)
RHEA:38063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-GGA-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Gallus gallus)
RHEA:50774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H(+) + H2O2 + nitrite => H2O + nitroethane + O2
REACT:R-MMU-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Mus musculus)
REACT:R-SSC-5694427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA3 binds procollagen VII (Sus scrofa)
RHEA:60728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citral + H2O + NADP(+) = 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH
RHEA:49785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + taurine => CoA + H(+) + taurochenodeoxycholate
GO:0033413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGU codon-amino acid adaptor activity
GO:0033413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGT codon-amino acid adaptor activity
GO:0033413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine tRNA
RHEA:30249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 2 plastoquinol-9 => 2 H2O + 4 hnu + 2 plastoquinone-9
GO:0000976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription regulatory region DNA binding
GO:0000976	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase regulatory region DNA binding
GO:0000976	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding
GO:0000976	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	regulatory region DNA binding
GO:0000976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription cis-regulatory region binding
GO:0000976	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding
GO:0000976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription regulatory region sequence-specific DNA binding
GO:0000976	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	eubacterial-type RNA polymerase regulatory region DNA binding
REACT:R-DRE-5662986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds copper (Danio rerio)
RHEA:53283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threose <=> D-erythrulose
REACT:R-CEL-2076419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Caenorhabditis elegans)
REACT:R-HSA-9024967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDNF-bound NTRK2 dimerizes (Homo sapiens)
REACT:R-XTR-205231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of KIT upon SCF binding (Xenopus tropicalis)
RHEA:72058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate(out) + 2 Na(+)(out) <=> glycodeoxycholate(in) + 2 Na(+)(in)
REACT:R-DRE-390250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Danio rerio)
REACT:R-SPO-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)
REACT:R-GGA-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Gallus gallus)
RHEA:66258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + IC-asc-C7-AMP => ATP + H(+) + IC-asc-C7
RHEA:45610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine => H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine
GO:0102776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity
RHEA:53512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate
RHEA:16287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine + NADH + pyruvate => D-octopine + H2O + NAD(+)
REACT:R-MMU-9794008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC binds CFLAR (Mus musculus)
REACT:R-CFA-173636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of classic pathway C5 convertase (Canis familiaris)
EC:3.1.3.55	skos:prefLabel	"caldesmon-phosphatase"
EC:3.1.3.55	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caldesmon-phosphatase"
REACT:R-SCE-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Saccharomyces cerevisiae)
RHEA:42252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + pentanoyl-CoA = 3-oxoheptanoyl-[ACP] + CO2 + CoA
REACT:R-DRE-8937191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Danio rerio)
REACT:R-MMU-448603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33:IL1RL1 binds IL1RAP-1 (Mus musculus)
REACT:R-SSC-977371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates Factor H-boundC3b (Sus scrofa)
REACT:R-GGA-873921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of STAT1 to p-IFNGR1 (Gallus gallus)
RHEA:11604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA
REACT:R-SSC-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Sus scrofa)
REACT:R-BTA-9656891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1SW binds 11cRAL (Bos taurus)
RHEA:41088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-MMU-210426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamate synaptic vesicle docking and priming (Mus musculus)
RHEA:66307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide
RHEA:66181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + bilirubin-glucuronoside(in) + H2O => ADP + bilirubin-glucuronoside(out) + H(+) + phosphate
REACT:R-CEL-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Caenorhabditis elegans)
REACT:R-HSA-6814764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasma membrane resorption (Homo sapiens)
RHEA:69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate
EC:2.1.1.275	skos:prefLabel	"gibberellin A9 O-methyltransferase"
EC:2.1.1.275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gibberellin A9 O-methyltransferase"
REACT:R-BTA-2130725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of MHC II:Ii clathrin coated vesicle (Bos taurus)
RHEA:32395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4S)-dihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH
RHEA:46860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP
RHEA:49754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 H2O + NAD(+) + proviolacein => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate
RHEA:36244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + NADP(+) + trans-anol => NADPH + trans-coumaryl acetate
REACT:R-HSA-265424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Homo sapiens)
RHEA:51718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out)
REACT:R-XTR-158747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Xenopus tropicalis)
REACT:R-GGA-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Gallus gallus)
REACT:R-BTA-3318413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Bos taurus)
RHEA:30599	skos:altLabel	"3-step phytoene desaturase"
RHEA:30599	skos:prefLabel	"phytoene desaturase (neurosporene-forming)"
RHEA:30599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 3 A = 3 AH2 + all-trans-neurosporene
RHEA:30599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phytoene desaturase (neurosporene-forming)"
RHEA:18296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + oxalate <=> AMP + diphosphate + oxalyl-CoA
RHEA:20482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + coelenterazine h => adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate
RHEA:66348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A = (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2
REACT:R-SSC-139909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BMF to mitochondria (Sus scrofa)
REACT:R-HSA-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Homo sapiens)
REACT:R-PFA-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Plasmodium falciparum)
RHEA:49597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-galactose => H(+) + N-acyl-D-galactosylsphing-4-enine + UDP
REACT:R-HSA-182859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)
REACT:R-HSA-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Homo sapiens)
GO:0036317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosyl-RNA phosphodiesterase activity
GO:0036317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity
GO:0036317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	unlinkase activity
GO:0036317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y-pUpN PDE activity
GO:0036317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPg unlinkase activity
RHEA:69986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:12381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2,4-diaminobutanoate + pyruvate => L-alanine + L-aspartate 4-semialdehyde
REACT:R-GGA-5696914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP28 deubiquitinates CLSPN and MYC (Gallus gallus)
REACT:R-GGA-8854612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 accelerates GTP hydrolysis by RAB33B (Gallus gallus)
REACT:R-RNO-2730842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K associates with phosphorylated GAB2 (Rattus norvegicus)
REACT:R-DME-201595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plakophilin-1 (Drosophila melanogaster)
REACT:R-SSC-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Sus scrofa)
REACT:R-DRE-190681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in endoplasmic reticulum membrane (Danio rerio)
REACT:R-CEL-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Caenorhabditis elegans)
GO:0140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA uracil 4 sulfurtransferase
GO:0140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA U4 sulfurtransferase
GO:0140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA uracil 4-sulfurtransferase
RHEA:71722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) <=> H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)
RHEA:70364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanurate + H2O => 1-carboxybiuret + H(+)
REACT:R-GGA-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Gallus gallus)
RHEA:66920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate = (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate
REACT:R-XTR-5610720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI3 (Xenopus tropicalis)
REACT:R-CFA-201637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plectin-1 (Canis familiaris)
RHEA:72921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II => 4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DDI-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Dictyostelium discoideum)
REACT:R-DDI-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Dictyostelium discoideum)
RHEA:42590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate
REACT:R-SSC-204861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shc1 (Sus scrofa)
GO:0140656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endodeoxyribonuclease activator activity
REACT:R-DME-211164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO1A (Drosophila melanogaster)
RHEA:57010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+) => 5,5'-dehydrodivanillate + H(+) + NADH + O2
REACT:R-CFA-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Canis familiaris)
REACT:R-GGA-1227732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IPS1 interacts with TRADD, RIP1 and FADD (Gallus gallus)
REACT:R-SSC-350869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Sus scrofa)
REACT:R-GGA-388605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMC(138-176) binds MC2R (Gallus gallus)
REACT:R-SCE-9638127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G6P to G1P (Saccharomyces cerevisiae)
RHEA:52146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-(phosphonomethyl)malate + CoA + H(+) => 3-phosphonopyruvate + acetyl-CoA + H2O
RHEA:19832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + O2 <=> an aldehyde + H2O2
RHEA:10328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-glycol + NAD(+) = a 2-hydroxycarbonyl + H(+) + NADH
REACT:R-RNO-8948063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Rattus norvegicus)
REACT:R-HSA-5687673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)
REACT:R-SSC-158468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates PARA to PARA-SO4 (Sus scrofa)
RHEA:65638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine => sphinga-(4E,8E)-dienine + tetracosanoyl-CoA
REACT:R-SPO-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Schizosaccharomyces pombe)
RHEA:58665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + a quinone => 2-oxoglutarate + a quinol
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 1,6-bisphosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose diphosphate phosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose 1,6-diphosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-1,6-bisphosphate 1-phosphohydrolase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose diphosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 1,6-diphosphate phosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-1,6-bisphosphate phosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 1,6-bisphosphate phosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fructose-bisphosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose-1,6-bisphosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hexosediphosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 1,6-diphosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexose bisphosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FBPase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexose diphosphatase activity
GO:0042132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose bisphosphate phosphatase activity
REACT:R-DRE-5654734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Danio rerio)
REACT:R-HSA-975100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
REACT:R-HSA-74220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Homo sapiens)
RHEA:54941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]
RHEA:18200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-cyclohexylformamide <=> cyclohexyl isocyanide + H2O
REACT:R-MMU-8955285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Mus musculus)
RHEA:69824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6802925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
REACT:R-DRE-422104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase octanoylates Proghrelin (Danio rerio)
REACT:R-HSA-8983394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)
REACT:R-SSC-1482546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)
RHEA:40347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanedioyl-CoA + CoA = acetyl-CoA + dodecanedioyl-CoA
RHEA:62240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine(6-4)cytidine in DNA = a thymine-cytidine dinucleotide in DNA
RHEA:53885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + CDP + H(+)
RHEA:67789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin
REACT:R-BTA-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Bos taurus)
REACT:R-RNO-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Rattus norvegicus)
REACT:R-SSC-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Sus scrofa)
RHEA:61788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-tryptophan--[L-tryptophyl-carrier protein] ligase"
RHEA:61788	skos:prefLabel	"L-tryptophan--[L-tryptophyl-carrier protein] ligase"
RHEA:61788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-tryptophan = AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]
RHEA:38339	skos:prefLabel	"20-O-multi-glycoside ginsenosidase"
RHEA:38339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb1 + H2O = (20S)-ginsenoside Rd + D-glucose
RHEA:38339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"20-O-multi-glycoside ginsenosidase"
RHEA:52999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH <=> [eIF5A protein]-deoxyhypusine + NAD(+)
REACT:R-HSA-5602712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TICAM1 deficiency blocks TLR3 pathway (Homo sapiens)
REACT:R-MMU-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Mus musculus)
RHEA:67589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)
RHEA:34383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP
REACT:R-RNO-917933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Rattus norvegicus)
REACT:R-HSA-373736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Shootin-1 links L1 and retrograde actin flow (Homo sapiens)
REACT:R-HSA-9638090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)
RHEA:28551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + anthranilate => CoA + N-acetylanthranilate
RHEA:49091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + H2O + squalene <=> FADH2 + hydroxysqualene
REACT:R-BTA-9717206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Bos taurus)
REACT:R-SSC-8950448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Sus scrofa)
RHEA:52263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1),7(1)-dihydroxybacteriochlorophyllide c <=> a bacteriochlorophyllide e + H2O
REACT:R-CFA-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Canis familiaris)
RHEA:15107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + kaempferide + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine
RHEA:53565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-965067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)
REACT:R-CEL-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Caenorhabditis elegans)
REACT:R-BTA-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Bos taurus)
RHEA:60815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A12 aldehyde + O2 <=> CO2 + gibberellin A12 + H(+) + succinate
RHEA:69762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + nonanal <=> 2 H(+) + NADH + nonanoate
RHEA:50924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
GO:0004754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
GO:0004754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)
GO:0004754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
GO:0004754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
GO:0004754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)
GO:0004754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)
RHEA:18609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate
RHEA:18609	skos:altLabel	"AOTC"
RHEA:18609	skos:altLabel	"N-acetylornithine transcarbamylase"
RHEA:18609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylornithine carbamoyltransferase"
RHEA:18609	skos:prefLabel	"N-acetylornithine carbamoyltransferase"
RHEA:18609	skos:altLabel	"acetylornithine transcarbamylase"
REACT:R-BTA-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Bos taurus)
GO:0072591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate-L-glutamate ligase activity
REACT:R-DRE-9758090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Danio rerio)
RHEA:40669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminopropanoate => 2-aminoprop-2-enoate
GO:0052750	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	versatile peroxidase activity
GO:0052750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reactive-black-5:hydrogen-peroxide oxidoreductase activity
RHEA:24418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + formate + 2 H(+) => 2,4'-dihydroxyacetophenone + O2
RHEA:33862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S-3S)-versiconal hemiacetal <=> H2O + versicolorin B
RHEA:39835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate
RHEA:56509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP
REACT:R-CEL-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Caenorhabditis elegans)
RHEA:13933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate
RHEA:56512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate
RHEA:63755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kermesate + UDP-alpha-D-glucose <=> carminate + 2 H(+) + UDP
REACT:R-CFA-209061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)
REACT:R-HSA-3000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BORA binds PLK1 and AURKA (Homo sapiens)
RHEA:46230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein] => apo-[peptidyl-carrier protein] + CoA
RHEA:11393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4-trisphosphate + phosphate
RHEA:53723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate
RHEA:53994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O
REACT:R-MMU-192335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Mus musculus)
RHEA:36888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O
RHEA:66877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-8850539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GNB5:RGS dimers from CCT/TRiC (Gallus gallus)
RHEA:51002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine => [fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine
REACT:R-DDI-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Dictyostelium discoideum)
RHEA:16838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-acylphosphoadenosine + H2O => a carboxylate + AMP + 2 H(+)
RHEA:62880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 = (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A
RHEA:65199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine <=> H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine
RHEA:48180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-XTR-8944229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type IX (Xenopus tropicalis)
REACT:R-BTA-77312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Bos taurus)
REACT:R-CEL-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Caenorhabditis elegans)
RHEA:28167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-nitroanthranilate + H(+) + H2O => 5-nitrosalicylate + NH4(+)
RHEA:17881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate
RHEA:17881	skos:prefLabel	"N-sulfoglucosamine sulfohydrolase"
RHEA:17881	skos:altLabel	"sulphamidase"
RHEA:17881	skos:altLabel	"sulfoglucosamine sulfamidase"
RHEA:17881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-sulfoglucosamine sulfohydrolase"
REACT:R-RNO-139898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 activates BID by cleavage (Rattus norvegicus)
RHEA:17910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate => acetaldehyde + formate
REACT:R-RNO-844619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIM2 binds dsDNA (Rattus norvegicus)
GO:0008126	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	C-esterase (in animal tissues)
GO:0008126	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-nitrophenyl acetate esterase
GO:0008126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylesterase activity
GO:0008126	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetic ester hydrolase activity
GO:0008126	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	citrus acetylesterase
GO:0008126	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	chloroesterase
GO:0008126	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetic-ester acetylhydrolase activity
RHEA:60809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A19 + H(+) + O2 => CO2 + gibberellin A20 + H2O
REACT:R-HSA-6805276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates TP53 (Homo sapiens)
REACT:R-DDI-8869456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP4 deubiquitinate TRAF2,TRAF6 (Dictyostelium discoideum)
RHEA:10274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+) => a 1,2-diacyl-sn-glycerol + ATP
REACT:R-DDI-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)
RHEA:10455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Dictyostelium discoideum)
REACT:R-DME-209063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)
RHEA:61290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+) => 5-deoxy-D-ribose + ATP
REACT:R-XTR-5689630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BAP1-interacting complex (Xenopus tropicalis)
REACT:R-BTA-8987220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Bos taurus)
REACT:R-DRE-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Danio rerio)
RHEA:41727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33283	skos:prefLabel	"2-hydroxycyclohexanone 2-monooxygenase"
RHEA:33283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxycyclohexanone 2-monooxygenase"
RHEA:33283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP(+)
REACT:R-HSA-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)
REACT:R-SSC-8938431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 and BTN1A1 binds periplakin (PPL) (Sus scrofa)
REACT:R-HSA-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
RHEA:27440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione amide + H2O2 <=> glutathione amide disulfide + 2 H2O
REACT:R-CFA-9679477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFA inhibitors (Canis familiaris)
REACT:R-DRE-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Danio rerio)
REACT:R-MMU-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Mus musculus)
RHEA:62054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O
RHEA:40978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine
REACT:R-BTA-212642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamine transport into neurons (Bos taurus)
RHEA:23114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylphenol + CO2 => 6-methylsalicylate + H(+)
REACT:R-SPO-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Schizosaccharomyces pombe)
GO:0015503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-regulated potassium exporter activity
REACT:R-MMU-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Mus musculus)
RHEA:11816	skos:altLabel	"phosphohexose isomerase"
RHEA:11816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-6-phosphate isomerase"
RHEA:11816	skos:altLabel	"hexose monophosphate isomerase"
RHEA:11816	skos:altLabel	"phosphosaccharomutase"
RHEA:11816	skos:altLabel	"phosphoglucoisomerase"
RHEA:11816	skos:altLabel	"D-glucose-6-phosphate ketol-isomerase"
RHEA:11816	skos:altLabel	"oxoisomerase"
RHEA:11816	skos:altLabel	"phosphoglucose isomerase"
RHEA:11816	skos:altLabel	"phosphohexomutase"
RHEA:11816	skos:prefLabel	"glucose-6-phosphate isomerase"
RHEA:11816	skos:altLabel	"phosphohexoisomerase"
RHEA:11816	skos:altLabel	"hexosephosphate isomerase"
RHEA:11816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate
RHEA:35845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
RHEA:52988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[deoxyhypusine synthase]-L-lysine + dehydrospermidine = [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine
RHEA:12596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
REACT:R-CFA-5218851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Canis familiaris)
REACT:R-XTR-8852331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 translocates to the nucleus (Xenopus tropicalis)
REACT:R-BTA-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)
REACT:R-HSA-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Homo sapiens)
REACT:R-RNO-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
RHEA:53952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate = 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate
REACT:R-DDI-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)
RHEA:16155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O2 + NH4(+) => an aliphatic amine + H2O + O2
RHEA:29768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-methionine(out) + H2O => ADP + D-methionine(in) + H(+) + phosphate
GO:0003871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydropteroylglutamate-homocysteine transmethylase activity
GO:0003871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity
GO:0003871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine synthase (cobalamin-independent) activity
GO:0003871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity
GO:0003871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MetE
GO:0003871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalamin-independent methionine synthase activity
GO:0003871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydropteroyltriglutamate methyltransferase activity
GO:0003871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity
GO:0003871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0003871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homocysteine methylase activity
REACT:R-DME-174105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)
REACT:R-HSA-1591234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZBP1 binds cytosolic DNA (Homo sapiens)
REACT:R-BTA-2161795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Bos taurus)
RHEA:28539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A
RHEA:54061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (2Z,6E)-hedycaryol + diphosphate
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPfucose-glycoprotein fucosyltransferase activity
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose--glycoprotein fucosyltransferase activity
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycoprotein fucosyltransferase activity
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FucT
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoprotein 6-alpha-L-fucosyltransferase activity
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-fucose--glycoprotein fucosyltransferase activity
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1,6)fucosyltransferase activity
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1,6)fucosyltransferase activity
GO:0008424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-fucose--glycoprotein fucosyltransferase activity
RHEA:59696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotetraono-1,5-lactone + H2O = D-cellotetraonate + H(+)
GO:0005171	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hepatocyte growth factor receptor ligand
GO:0005171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF receptor binding
GO:0005171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hepatocyte growth factor receptor binding
GO:0005171	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hepatocyte growth factor
GO:0038021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leptin receptor activity
RHEA:58740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + psi-UTP = diphosphate + H(+) + psi-UMP
REACT:R-DME-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Drosophila melanogaster)
RHEA:41097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphocholine + sphing-4-enine => H2O + sphing-4-enine-phosphocholine
RHEA:55407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + UTP <=> [phosphate](n+1) + UDP
REACT:R-RNO-388817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICOS binds ICOSL/B7-H2 (Rattus norvegicus)
REACT:R-HSA-8931858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Homo sapiens)
RHEA:43478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2
REACT:R-CEL-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Caenorhabditis elegans)
REACT:R-DME-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Drosophila melanogaster)
RHEA:34066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + H(+) + UDP
RHEA:18504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol + NADP(+) <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH
REACT:R-RNO-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)
REACT:R-HSA-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Homo sapiens)
REACT:R-MMU-9604480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFkB complex translocates from the cytosol to the nucleus (Mus musculus)
REACT:R-BTA-420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretin receptor binds secretin (Bos taurus)
REACT:R-GGA-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Gallus gallus)
RHEA:42450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-glutaconyl-CoA + H2O => (R)-2-hydroxyglutaryl-CoA
GO:0001537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine 4-O-sulphotransferase activity
GO:0001537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine 4-O-sulfotransferase activity
RHEA:38838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:61064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP
RHEA:46026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine-D-fructose-6-phosphate amidotransferase activity
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosamine-6-phosphate isomerase (glutamine-forming) activity
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine 6-phosphate synthase activity
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-6-phosphate amidotransferase activity
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glucosaminephosphate isomerase
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcN6P synthase activity
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexosephosphate aminotransferase activity
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
GO:0004360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosamine-6-phosphate synthase activity
REACT:R-CFA-2267372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Canis familiaris)
RHEA:41673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycerol + ATP => 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)
GO:0102960	skos:altLabel	"momilactone A synthase"
GO:0102960	skos:prefLabel	"momilactone-A synthase"
GO:0102960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"momilactone-A synthase"
GO:0102960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	momilactone-A synthase activity
RHEA:15597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-siderophore(in) + ADP + H(+) + phosphate
REACT:R-SPO-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Schizosaccharomyces pombe)
RHEA:16058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-CEL-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Caenorhabditis elegans)
REACT:R-RNO-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Rattus norvegicus)
REACT:R-RNO-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Rattus norvegicus)
REACT:R-SSC-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Sus scrofa)
REACT:R-CEL-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Caenorhabditis elegans)
RHEA:21067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + 2 glutathione <=> [protein]-dithiol + glutathione disulfide
REACT:R-GGA-451463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex  (Gallus gallus)
REACT:R-CEL-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Caenorhabditis elegans)
RHEA:30216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 2 nitric oxide => a menaquinone + H2O + nitrous oxide
REACT:R-BTA-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)
REACT:R-XTR-2179276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 monoubiquitinates SMAD3 (Xenopus tropicalis)
RHEA:21111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + H(+) <=> 2-methylbutanal + CO2
GO:0018492	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anaerobic carbon monoxide dehydrogenase activity
GO:0018492	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbon-monoxide:acceptor oxidoreductase activity
GO:0018492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-monoxide dehydrogenase (acceptor) activity
GO:0018492	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carbon monoxide dehydrogenase activity
REACT:R-SPO-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Schizosaccharomyces pombe)
REACT:R-CFA-6786205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Canis familiaris)
REACT:R-DRE-378952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin is a heterodimer (Danio rerio)
REACT:R-DME-3262512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Drosophila melanogaster)
GO:0047729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnitine decarboxylase"
GO:0047729	skos:altLabel	"carnitine carboxy-lyase"
GO:0047729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine decarboxylase activity
GO:0047729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine carboxy-lyase activity
GO:0047729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine carboxy-lyase (2-methylcholine-forming)
GO:0047729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine + H(+) = 2-methylcholine + CO2
GO:0047729	skos:prefLabel	"carnitine decarboxylase"
REACT:R-DRE-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Danio rerio)
REACT:R-XTR-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Xenopus tropicalis)
REACT:R-SSC-8959719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPK phosphorylates Sedo to Sedo7P (Sus scrofa)
REACT:R-HSA-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Homo sapiens)
REACT:R-CEL-5654586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)
RHEA:25378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxy-3-methyl fatty acyl-CoA <=> a 2-methyl-branched fatty aldehyde + formyl-CoA
GO:0002173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity IgM receptor activity
GO:0002173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity IgM receptor activity
RHEA:53922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein] => ATP + L-threonyl-[Fas-activated protein]
REACT:R-SSC-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Sus scrofa)
REACT:R-CEL-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
REACT:R-SSC-5333051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA1 binds HSF1 (Sus scrofa)
RHEA:72159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + taurocholate(out) = glutarate(out) + taurocholate(in)
GO:0015377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation:chloride symporter activity
GO:0015377	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cation:chloride cotransporter activity
REACT:R-MMU-5213464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is phosphorylated (Mus musculus)
RHEA:54752	skos:altLabel	"F420H2 dehydrogenase"
RHEA:54752	skos:prefLabel	"coenzyme F420:methanophenazine dehydrogenase"
RHEA:54752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) = dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)
RHEA:54752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coenzyme F420:methanophenazine dehydrogenase"
REACT:R-DME-209143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of AXN and APC by DCO (Drosophila melanogaster)
REACT:R-RNO-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Rattus norvegicus)
RHEA:35563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-hexadecenoyl) ethanolamine = (9Z)-hexadecenoate + ethanolamine
RHEA:43918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:16953	skos:altLabel	"SOAT"
RHEA:16953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinylornithine transaminase"
RHEA:16953	skos:altLabel	"succinylornithine aminotransferase"
RHEA:16953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(2)-succinyl-L-ornithine = L-glutamate + N-succinyl-L-glutamate 5-semialdehyde
RHEA:16953	skos:prefLabel	"succinylornithine transaminase"
RHEA:16953	skos:altLabel	"N(2)-succinylornithine 5-aminotransferase"
REACT:R-PFA-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Plasmodium falciparum)
REACT:R-SSC-5693584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Sus scrofa)
REACT:R-HSA-5649664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyG from damaged DNA (Homo sapiens)
RHEA:56525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydro-heme d1 => AH2 + heme d1
RHEA:41400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:32275	skos:altLabel	"4-(phosphohydroxy)-L-threonine dehydrogenase"
RHEA:32275	skos:altLabel	"NAD(+)-dependent threonine 4-phosphate dehydrogenase"
RHEA:32275	skos:prefLabel	"4-hydroxythreonine-4-phosphate dehydrogenase"
RHEA:32275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxythreonine-4-phosphate dehydrogenase"
RHEA:32275	skos:altLabel	"L-threonine 4-phosphate dehydrogenase"
RHEA:32275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH
REACT:R-BTA-9670114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H3.3 deposition at telomere (Bos taurus)
REACT:R-XTR-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Xenopus tropicalis)
RHEA:51499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + ATP <=> a sphingoid 1-phosphate + ADP + H(+)
REACT:R-RNO-5632652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds CDON and PTCH (Rattus norvegicus)
REACT:R-HSA-192315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts are translocated from the peroxisomal matrix to the cytosol (Homo sapiens)
REACT:R-XTR-5654165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR1 (Xenopus tropicalis)
REACT:R-CEL-2187405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 binds phosphorylated SMAD2/3 (Caenorhabditis elegans)
GO:0033906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orgelase activity
GO:0033906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyaluronoglucuronidase activity
GO:0033906	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hyaluronidase activity
GO:0033906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronoglucosaminoglycan hyaluronate lyase activity
GO:0033906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hyaluronate 3-glycanohydrolase activity
RHEA:38556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an all-trans-retinyl ester + H2O => a fatty acid + all-trans-retinol + H(+)
RHEA:24447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]
RHEA:65371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
REACT:R-GGA-379387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DA to form 3MT (Gallus gallus)
RHEA:45664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-CEL-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Caenorhabditis elegans)
REACT:R-CEL-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Caenorhabditis elegans)
RHEA:42429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clavaminate => (3R,5R)-clavulanate-9-aldehyde
GO:0016843	skos:prefLabel	"Amine-lyases"
GO:0016843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Amine-lyases"
GO:0016843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amine-lyase activity
RHEA:11281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP
RHEA:43456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:23784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
RHEA:38346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + H2O <=> (20S)-ginsenoside Rg3 + D-glucose
EC:1.14.19.59	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan 6-halogenase"
EC:1.14.19.59	skos:prefLabel	"tryptophan 6-halogenase"
REACT:R-GGA-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Gallus gallus)
REACT:R-SPO-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Schizosaccharomyces pombe)
REACT:R-XTR-3301943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTK1 dimer transfers GS from GSH to CDNB (Xenopus tropicalis)
REACT:R-BTA-193533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)
REACT:R-CFA-354087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2 to p-PTK2 (Canis familiaris)
RHEA:62002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + protoporphyrin IX => 3 A + protoporphyrinogen IX
REACT:R-RNO-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Rattus norvegicus)
RHEA:30257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinone + 2 H2O => 2 a ubiquinol + O2
RHEA:17614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + scyllo-inositol => H(+) + NADH + scyllo-inosose
RHEA:24696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferyl acetate + NADPH => acetate + NADP(+) + trans-isoeugenol
RHEA:20290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoA + H(+)
RHEA:28142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + streptothricin D = streptothricin D acid
REACT:R-DME-8855711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Drosophila melanogaster)
REACT:R-RNO-193646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF binding to p75NTR inactivates RHOA (Rattus norvegicus)
GO:0008131	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	amine oxidase activity
GO:0008131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	primary amine oxidase activity
GO:0008131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	primary-amine:oxygen oxidoreductase (deaminating) activity
GO:0008131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	amine oxidase (copper-containing) activity
GO:0018506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoadipate:NAD(P)+ oxidoreductase activity
GO:0018506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetate reductase activity
GO:0018506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maleolylacetate reductase activity
GO:0106438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glutamic acid ligase activity, elongating
GO:0106438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate
REACT:R-HSA-2666278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 (Homo sapiens)
REACT:R-XTR-5654622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)
RHEA:54918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinal + H(+) + NADPH => 9-cis-retinol + NADP(+)
REACT:R-HSA-166271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)
REACT:R-MMU-4420121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate PLCG1 (Mus musculus)
REACT:R-CFA-5678313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Canis familiaris)
RHEA:16324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-indan-1-ol + NADP(+) <=> H(+) + indan-1-one + NADPH
RHEA:39824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:40324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:37301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + L-threonine => H2O + L-alanyl-L-threonine
RHEA:22435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3S)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH
REACT:R-HSA-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
REACT:R-HSA-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Homo sapiens)
REACT:R-RNO-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Rattus norvegicus)
REACT:R-BTA-1247668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A binds O2, releasing H+ and CO2 (Bos taurus)
RHEA:42062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinal + H(+) + NADH => 11-cis-retinol + NAD(+)
RHEA:50850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2
REACT:R-MMU-6784676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Mus musculus)
REACT:R-RNO-1676005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Rattus norvegicus)
REACT:R-HSA-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Homo sapiens)
RHEA:15862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ADP-2-phosphoglycerate + H2O => 3-ADP-glycerate + phosphate
RHEA:33552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + H2O => a fatty acid + sphinganine
REACT:R-SSC-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Sus scrofa)
REACT:R-XTR-1592436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP9 by MMPs (Xenopus tropicalis)
REACT:R-CEL-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)
RHEA:48560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine
REACT:R-MMU-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Mus musculus)
RHEA:44479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine
REACT:R-DRE-399978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase C, alpha type phosphorylates MARCKS (Danio rerio)
REACT:R-SPO-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Schizosaccharomyces pombe)
REACT:R-XTR-5696356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSCAR binds collagen and SP-D (Xenopus tropicalis)
REACT:R-MMU-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)
RHEA:53213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6800836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 or TP63 binds the PERP gene (Homo sapiens)
GO:1990585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyproline O-arabinosyltransferase activity
GO:1990585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPAT
REACT:R-RNO-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Rattus norvegicus)
REACT:R-SSC-77331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Sus scrofa)
REACT:R-DRE-1454791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP7, MMP9 bind CD44 (Danio rerio)
RHEA:65635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + tetracosanoyl-CoA <=> an N-tetracosanoyl-sphingoid base + CoA + H(+)
REACT:R-MMU-1971487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHSY3 transfer GalNAc to chondroitin (Mus musculus)
GO:0030519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snoRNP binding
REACT:R-BTA-8874208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Bos taurus)
RHEA:31139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-5-ene-steroid dehydrogenase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-ene-3-beta-hydroxysteroid dehydrogenase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-HSDH
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-5-ene steroid dehydrogenase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid-delta5-3beta-ol dehydrogenase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	progesterone reductase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-beta-hydroxy-D5-steroid dehydrogenase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-5-ene-steroid oxidoreductase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3beta-hydroxy-delta5-C27-steroid oxidoreductase
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy steroid dehydrogenase/isomerase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-beta-hydroxy-5-ene steroid dehydrogenase activity
GO:0003854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta5-3beta-hydroxysteroid dehydrogenase activity
RHEA:20253	skos:prefLabel	"dimethylmaleate hydratase"
RHEA:20253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylmaleate hydratase"
RHEA:20253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O
REACT:R-SSC-9632918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Sus scrofa)
REACT:R-BTA-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Bos taurus)
REACT:R-BTA-1614362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Bos taurus)
RHEA:35374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate
REACT:R-CFA-380294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of C-Nap-1 from centrosomes (Canis familiaris)
REACT:R-DDI-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Dictyostelium discoideum)
RHEA:46484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:38257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl-CoA + succinate => (S)-malate + succinyl-CoA
GO:0008727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-mannose mannosyl hydrolase activity
REACT:R-RNO-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Rattus norvegicus)
REACT:R-MMU-391939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP receptor can bind thromboxane (Mus musculus)
GO:0004896	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL receptor
GO:0004896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hematopoietin/interferon-class (D200-domain) cytokine receptor activity
GO:0004896	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin receptor activity
GO:0004896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokine receptor activity
GO:0102423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sesaminol 2-O-glucosyltransferase activity
RHEA:50896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O = (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate
REACT:R-DDI-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
RHEA:10435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acetamidomethylene)succinate + H(+) + 2 H2O <=> acetate + CO2 + NH4(+) + succinate semialdehyde
REACT:R-CFA-352385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Canis familiaris)
RHEA:64938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGDP + H(+) + phosphate => dGTP + H2O
RHEA:40063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O = 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA
REACT:R-HSA-9665413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1  (Homo sapiens)
RHEA:62835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate
REACT:R-RNO-75883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHRS7B reduces GO3P to HXDG3P (Rattus norvegicus)
REACT:R-DDI-5696947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP47 deubiquitinates POLB (Dictyostelium discoideum)
REACT:R-XTR-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Xenopus tropicalis)
REACT:R-BTA-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Bos taurus)
REACT:R-DRE-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Danio rerio)
RHEA:62059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)
REACT:R-HSA-9668395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CC2D1B (Homo sapiens)
RHEA:37614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-BTA-388981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Kiss receptor GPR54 binds kisspeptin (Bos taurus)
REACT:R-GGA-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Gallus gallus)
REACT:R-RNO-6788628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dissociate (Rattus norvegicus)
RHEA:51766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlorisovalerophenone + diphosphate => dimethylallyl diphosphate + phlorisovalerophenone
REACT:R-DDI-76456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-atom dealkylation of dextromethorphan (Dictyostelium discoideum)
REACT:R-RNO-1067688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)
REACT:R-DRE-174439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Danio rerio)
GO:0031624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin conjugating enzyme binding
RHEA:33915	skos:prefLabel	"4-methylaminobutanoate oxidase (methylamine-forming)"
RHEA:33915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-methylaminobutanoate oxidase (methylamine-forming)"
RHEA:33915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(methylamino)butanoate + H2O + O2 = H2O2 + methylamine + succinate semialdehyde
RHEA:20349	skos:prefLabel	"toluene 2-monooxygenase"
RHEA:20349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"toluene 2-monooxygenase"
RHEA:20349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytoluene + H(+) + NADH + O2 = 3-methylcatechol + H2O + NAD(+)
RHEA:20349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene = 2-hydroxytoluene + H2O + NAD(+)
RHEA:20349	skos:altLabel	"toluene ortho-monooxygenase"
REACT:R-HSA-8932276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)
REACT:R-DME-976801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I complex formation (Drosophila melanogaster)
REACT:R-SSC-114577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Sus scrofa)
RHEA:55657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + a carotenoid beta-end derivative => a carotenoid chi-end derivative + 2 AH2
RHEA:39350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)
REACT:R-GGA-437999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
RHEA:16091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine + phosphate => H2O + phosphoethanolamine
REACT:R-MMU-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Mus musculus)
REACT:R-HSA-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Homo sapiens)
REACT:R-HSA-167292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)
REACT:R-GGA-383363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 2 (NK2) binds to nuerokinin A (Gallus gallus)
RHEA:69691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine = ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP
REACT:R-DRE-6801766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Danio rerio)
REACT:R-MMU-1964501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Mus musculus)
REACT:R-HSA-9690395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOX9 binds the SOX9 gene (Homo sapiens)
REACT:R-XTR-212005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2F1 dehydrogenates 3-methylindole (Xenopus tropicalis)
REACT:R-DRE-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Danio rerio)
RHEA:10023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH
RHEA:41419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-DME-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Drosophila melanogaster)
RHEA:42294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl phosphate + holo-[ACP] => a fatty acyl-[ACP] + phosphate
RHEA:12972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sn-glycero-3-phosphodiester + H2O <=> an alcohol + H(+) + sn-glycerol 3-phosphate
RHEA:55082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + sucrose => ADP-alpha-D-glucose + D-fructose
RHEA:22827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + uracil
RHEA:11585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine => D-ornithine
RHEA:34530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine <=> (S)-3-amino-3-phenylpropanoate
REACT:R-CEL-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Caenorhabditis elegans)
RHEA:36192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine
REACT:R-CEL-9749647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES2 hydrolyzes ASA- (Caenorhabditis elegans)
REACT:R-HSA-429581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 transports vitamins from extracellular region to cytosol (Homo sapiens)
REACT:R-DDI-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:36228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)
GO:0044548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100 binding
GO:0044548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100 protein binding
GO:0044548	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	S100 alpha binding
GO:0044548	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	S100 beta binding
RHEA:47683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactosamine 6-phosphate + H2O <=> D-tagatopyranose 1-phosphate + NH4(+)
REACT:R-HSA-2731002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN3 exchanges Cl- for H+ (Homo sapiens)
RHEA:63034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + NH4(+) => a fatty acylamide + H2O
RHEA:23076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-dichlorobenzoyl-CoA reductase"
RHEA:23076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH
RHEA:23076	skos:prefLabel	"2,4-dichlorobenzoyl-CoA reductase"
REACT:R-HSA-9727284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9b forms a homodimer (Homo sapiens)
REACT:R-DRE-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Danio rerio)
REACT:R-MMU-5324617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:FKBP4:PTGES3 binds HSF1 trimer (Mus musculus)
GO:0003905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylbase DNA N-glycosylase activity
GO:0003905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylbase DNA glycosidase activity
GO:0003905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-3-methyladenine glycosidase II activity
GO:0003905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA glycosidase II activity
GO:0003905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleate 3-methyladenine glycosidase II
GO:0003905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyladenine DNA glycosylase II
GO:0003905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-3-methyladenine glycosylase II
GO:0003905	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
GO:0003905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AlkA
REACT:R-GGA-2396029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-3 binds integrins (Gallus gallus)
RHEA:16818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH
RHEA:22841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamine + H2O => D-glutamate + NH4(+)
REACT:R-HSA-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Homo sapiens)
REACT:R-BTA-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Bos taurus)
REACT:R-RNO-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Rattus norvegicus)
REACT:R-HSA-8934688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds the LIFR gene promoter (Homo sapiens)
REACT:R-CFA-209566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is auto-ubiquitinated (Canis familiaris)
REACT:R-HSA-2730902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of p-CARMA1 (Homo sapiens)
REACT:R-HSA-9617194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-STAT3 binds the promoter of the CEBPB gene (Homo sapiens)
REACT:R-CEL-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Caenorhabditis elegans)
RHEA:57673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] => 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)
REACT:R-HSA-1250353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Homo sapiens)
REACT:R-HSA-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Homo sapiens)
RHEA:34593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-7 + S-adenosyl-L-methionine
REACT:R-MMU-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Mus musculus)
RHEA:33152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoamide + acetyl-CoA => (R)-S(6)-acetyldihydrolipoamide + CoA
REACT:R-HSA-8937118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter (Homo sapiens)
RHEA:72744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene C4(out) => leukotriene C4(in)
RHEA:72872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A3 + malonyl-CoA => anthocyanin A5 + CoA
REACT:R-DRE-2730868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK7 by MEKK1 (Danio rerio)
REACT:R-CFA-1236940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exogenous soluble antigen targeted to more stable early endosome (Canis familiaris)
RHEA:10353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetylarylalkylamine + H2O => acetate + an aralkylamine
REACT:R-SSC-389622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Sus scrofa)
RHEA:54175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:61720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-guloside + NAD(+) = a 3-dehydro-D-guloside + H(+) + NADH
GO:0098699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of presynaptic actin cytoskeleton
REACT:R-HSA-8876246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	InlB-activated MET phosphorylates CBL (Homo sapiens)
REACT:R-GGA-8964634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Gallus gallus)
REACT:R-GGA-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Gallus gallus)
REACT:R-RNO-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Rattus norvegicus)
RHEA:18334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + oleandomycin => ADP + H(+) + oleandomycin 2'-O-phosphate
RHEA:26468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + S-adenosyl-L-methionine
REACT:R-CFA-5689630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BAP1-interacting complex (Canis familiaris)
REACT:R-BTA-194017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 11DCORST to CORST (Bos taurus)
RHEA:64120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-serine + H2O = a fatty acid + L-serine
REACT:R-RNO-3222593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B demethylates H3K27me3 on p16INK4A promoter (Rattus norvegicus)
RHEA:50386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline
REACT:R-HSA-112153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters (Homo sapiens)
REACT:R-BTA-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Bos taurus)
REACT:R-CFA-5223305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL, inhibiting it (Canis familiaris)
REACT:R-DRE-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Danio rerio)
REACT:R-GGA-2424477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS mediated nucleotide exchange of RAS (SHC) (Gallus gallus)
REACT:R-CFA-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Canis familiaris)
REACT:R-DME-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Drosophila melanogaster)
RHEA:62060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)
REACT:R-BTA-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Bos taurus)
RHEA:71624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(out) + phosphate(in) => malonate(in) + phosphate(out)
REACT:R-MMU-1306963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Mus musculus)
REACT:R-SSC-936380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PIN1 with p-IRF3 (Sus scrofa)
REACT:R-CFA-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Canis familiaris)
REACT:R-CFA-5654591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
RHEA:45667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-HSA-937343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)
RHEA:11575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + H2O + lithocholate <=> chenodeoxycholate + FADH2
RHEA:29398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UTP <=> diphosphate + H(+) + UMP
REACT:R-BTA-3240295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Bos taurus)
RHEA:62425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + H2O => 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA
RHEA:49348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dihydroxyspirilloxanthin = 2-oxospirilloxanthin + H2O
GO:0047714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polygalactolipase activity
GO:0047714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity
GO:0047714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactolipid lipase activity
GO:0047714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactolipase activity
GO:0047714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactolipid acylhydrolase activity
GO:0034933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxypyrene methyltransferase activity
RHEA:51422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3S)-flavan-3-ol + 2 NADP(+)
RHEA:24477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + maleimide => H(+) + maleamate
RHEA:48584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin A4
REACT:R-CEL-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Caenorhabditis elegans)
REACT:R-HSA-1369052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid influx (Homo sapiens)
REACT:R-RNO-8941623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
REACT:R-DRE-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Danio rerio)
GO:0102540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate 1-epimerase activity
REACT:R-SSC-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Sus scrofa)
REACT:R-HSA-6785722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript (Homo sapiens)
REACT:R-DDI-109860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 phosphorylates MAPK3 (Dictyostelium discoideum)
REACT:R-BTA-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Bos taurus)
GO:0051506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol UDP-glucosyltransferase activity
REACT:R-BTA-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Bos taurus)
REACT:R-BTA-8932955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Bos taurus)
GO:0047147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trimethylsulfonium--tetrahydrofolate N-methyltransferase"
GO:0047147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethylsulfonium:tetrahydrofolate N-methyltransferase activity
GO:0047147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)
GO:0047147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylsulfonium-tetrahydrofolate N-methyltransferase activity
GO:0047147	skos:prefLabel	"trimethylsulfonium--tetrahydrofolate N-methyltransferase"
GO:0047147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethylsulfonium-tetrahydrofolate methyltransferase activity
GO:0047147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylsulphonium-tetrahydrofolate N-methyltransferase activity
REACT:R-CFA-8851877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Canis familiaris)
REACT:R-CFA-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Canis familiaris)
RHEA:27332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + urate <=> 5-hydroxyisourate + H2O + NAD(+)
REACT:R-MMU-349637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spherical HDL and SR-BI receptor form a complex at the cell surface (Mus musculus)
RHEA:17533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-glutamate
REACT:R-MMU-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Mus musculus)
RHEA:61904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone A + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin II
RHEA:46869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
RHEA:56904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-AMP + CoA = AMP + an acyl-CoA + H(+)
RHEA:48206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA
RHEA:24964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitetrol + H2O + 2 oxidized [adrenodoxin]
RHEA:48970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O => [thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2
REACT:R-BTA-5632738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDIT4 binds 14-3-3 dimer (Bos taurus)
REACT:R-BTA-349638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of SR-BI-bound spherical HDL (Bos taurus)
REACT:R-BTA-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Bos taurus)
RHEA:55342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol
REACT:R-GGA-9696323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNRs bind CNR agonists (Gallus gallus)
REACT:R-SCE-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Saccharomyces cerevisiae)
REACT:R-DME-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Drosophila melanogaster)
RHEA:67282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione => (2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione
RHEA:27980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-mannose + H2O
RHEA:50509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]
REACT:R-BTA-194310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Bos taurus)
RHEA:70574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + Na(+)(out) <=> D-glucose(in) + Na(+)(in)
GO:0102169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyocyanin hydroxylase activity
GO:0047574	skos:altLabel	"aminobutyryl-CoA thiolesterase"
GO:0047574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetylase-thiolesterase activity
GO:0047574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutyryl-CoA deacetylase activity
GO:0047574	skos:prefLabel	"4-acetamidobutyryl-CoA deacetylase"
GO:0047574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminobutyryl-CoA thiolesterase activity
GO:0047574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-acetamidobutyryl-CoA deacetylase"
GO:0047574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-acetamidobutanoyl-CoA amidohydrolase activity
GO:0047574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate
REACT:R-DRE-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Danio rerio)
REACT:R-DME-3215310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)
RHEA:29924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)
REACT:R-HSA-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Homo sapiens)
REACT:R-DRE-391943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLT2 binds LTC4,LTD4,LTE4 (Danio rerio)
REACT:R-CFA-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Canis familiaris)
REACT:R-RNO-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Rattus norvegicus)
RHEA:57033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O => CO2 + formate + methylamine + succinate semialdehyde
RHEA:29189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + ubiquinol-8 => succinate + ubiquinone-8
RHEA:52159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:25557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate => diphosphate + stemod-13(17)-ene
RHEA:68028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,8-dihydroxypurine + H2O + O2 = H2O2 + urate
RHEA:42562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(27/28) in mitochondrial tRNA => uridine(27/28) in mitochondrial tRNA
RHEA:32030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphate
RHEA:21759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylisoipecoside + H2O <=> dopamine + secologanin
REACT:R-BTA-373741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK2 homophillic interaction (Bos taurus)
REACT:R-BTA-6800035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP3 binds TMEM219 (Bos taurus)
REACT:R-GGA-177934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR autophosphorylation (Gallus gallus)
RHEA:45892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + CDP-ethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)
RHEA:69236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate = 4-hydroxybutylnitrile + sulfate + sulfur
RHEA:15309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]
RHEA:15309	skos:prefLabel	"phycocyanobilin:ferredoxin oxidoreductase"
RHEA:15309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phycocyanobilin:ferredoxin oxidoreductase"
RHEA:48068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate
REACT:R-DRE-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Danio rerio)
REACT:R-HSA-193642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of pro-NGF to p75NTR:sortilin (Homo sapiens)
REACT:R-CFA-425822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Canis familiaris)
RHEA:62449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP => AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]
RHEA:18381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate
RHEA:18381	skos:prefLabel	"phosphoenolpyruvate--glycerone phosphotransferase"
RHEA:18381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoenolpyruvate--glycerone phosphotransferase"
REACT:R-SSC-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Sus scrofa)
GO:0047797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexanone:acceptor 2-oxidoreductase activity
GO:0047797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanone dehydrogenase activity
GO:0047797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexanone:(acceptor) 2-oxidoreductase activity
REACT:R-RNO-9714361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC activates endoplasmic reticulum effectors (Rattus norvegicus)
RHEA:68746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine => 2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine
RHEA:14844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> ent-copalyl diphosphate
RHEA:27309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-proline <=> 1-pyrroline-2-carboxylate + AH2
REACT:R-SSC-9755306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub UBXN7 is degraded by the 26S proteasome (Sus scrofa)
REACT:R-CEL-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Caenorhabditis elegans)
RHEA:15959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + H2O => D-altronate
REACT:R-HSA-3779381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 diffuses from the mitochondrial matrix to the cytosol (Homo sapiens)
RHEA:40313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA + H2O2 => hexanoyl-CoA + O2
GO:0055055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose:hydrogen symporter activity
GO:0055055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose:proton symporter activity
REACT:R-BTA-6792871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNG1 recruits PP2A-PPP2R5C to MDM2 (Bos taurus)
RHEA:38674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate(in) <=> sphinganine 1-phosphate(out)
RHEA:31227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP
GO:0031996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioesterase binding
GO:0031996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiolesterase binding
RHEA:43833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
REACT:R-DRE-391940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 and EP4 receptors can bind PGE2 (Danio rerio)
RHEA:19381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-oxalosuccinate + H(+) = 2-oxoglutarate + CO2
RHEA:32522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + S-adenosyl-L-methionine <=> (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Danio rerio)
REACT:R-RNO-6798474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Zn2+ (Rattus norvegicus)
REACT:R-XTR-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Xenopus tropicalis)
REACT:R-CEL-392051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Grb2 to pFAK:NCAM1 (Caenorhabditis elegans)
REACT:R-SSC-9690494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB translocates to the endosome membrane (Sus scrofa)
REACT:R-CFA-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)
RHEA:53377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(16) in tRNA + NADP(+) => H(+) + NADPH + uridine(16) in tRNA
RHEA:58436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + H(+) + NADPH
REACT:R-BTA-111285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)
GO:0047248	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-nuatigenin glucosyltransferase activity
GO:0047248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuatigenin 3-beta-glucosyltransferase activity
GO:0047248	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity
GO:0047248	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity
GO:0047248	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nuatigenin 3beta-glucosyltransferase activity
REACT:R-GGA-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Gallus gallus)
REACT:R-MMU-173481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Mus musculus)
RHEA:31636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O => 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc
REACT:R-RNO-3322429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP monoubiquinates TLE (Rattus norvegicus)
RHEA:38223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + decan-1-ol = 1-O-decyl-(9Z)-octadecenoate + CoA
GO:0033943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactan 1,3-beta-galactosidase activity
GO:0033943	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactan (1->3)-beta-D-galactosidase activity
GO:0033943	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactan (1,3)-beta-D-galactosidase activity
RHEA:44073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + ATP => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SSC-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Sus scrofa)
RHEA:10797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole + H(+) + NADPH + O2 => albendazole S-oxide + H2O + NADP(+)
REACT:R-DRE-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Danio rerio)
RHEA:25369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + momilactone A + NADPH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+)
RHEA:34636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + pentalenolactone D
RHEA:29085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + ubiquinol-8 => (S)-malate + ubiquinone-8
REACT:R-DRE-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Danio rerio)
RHEA:29322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phosphoethanolamine <=> ethanolamine + H(+) + sn-glycerol 3-phosphate
REACT:R-XTR-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Xenopus tropicalis)
REACT:R-HSA-8878787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPI dimer hydrolyses phosphate monoesters (Homo sapiens)
REACT:R-BTA-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Bos taurus)
REACT:R-RNO-190408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2b (Rattus norvegicus)
EC:2.3.1.243	skos:prefLabel	"acyl-Kdo2-lipid IVA acyltransferase"
EC:2.3.1.243	skos:altLabel	"acyl-Kdo2-lipid IVA myristoyltransferase"
EC:2.3.1.243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-Kdo2-lipid IVA acyltransferase"
EC:2.3.1.243	skos:altLabel	"myristoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA O-myristoyltransferase"
GO:0031994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF-I binding
GO:0031994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin-like growth factor I binding
RHEA:22787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-O-phospho-3-sulfolactate <=> H(+) + phosphoenolpyruvate + sulfite
REACT:R-RNO-350158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGMN degrades GC (Rattus norvegicus)
REACT:R-DRE-195690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Danio rerio)
RHEA:60358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + H(+) + octanoate => H2O + N-octanoylanthranilate
REACT:R-DME-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Drosophila melanogaster)
RHEA:66044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + H2O + kynurenate
RHEA:27751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
REACT:R-GGA-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Gallus gallus)
REACT:R-CFA-2024084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS-GAGs translocate to the lysosome for degradation (Canis familiaris)
RHEA:56595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a disubstituted aliphatic (S)-hydroxynitrile <=> a ketone + hydrogen cyanide
REACT:R-BTA-194121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Bos taurus)
RHEA:70556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-galactosamine
REACT:R-DDI-9638127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G6P to G1P (Dictyostelium discoideum)
RHEA:71502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)
REACT:R-BTA-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Bos taurus)
RHEA:59275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine <=> D-cysteine
GO:0042903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC6 deacetylates microtubules (Homo sapiens)
GO:0042903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin deacetylase activity
REACT:R-SSC-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Sus scrofa)
REACT:R-DDI-2161794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is converted to HXA3/B3 by ALOX12 (Dictyostelium discoideum)
RHEA:49443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA <=> (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate
RHEA:46374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:56475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
RHEA:31814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + viridiflorene
REACT:R-CFA-1604690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MMP9 intermediate form by MMPs (Canis familiaris)
GO:0004698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent protein kinase C activity
GO:0004698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent PKC activity
GO:0004698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	conventional protein kinase C activity
REACT:R-BTA-210426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamate synaptic vesicle docking and priming (Bos taurus)
RHEA:57153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[protein] + O2 => (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate
REACT:R-RNO-1482689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)
REACT:R-SSC-5654641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
RHEA:58487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(acetyl)-sphing-4-enine <=> acetate + sphing-4-enine
REACT:R-DME-111966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 binds CALM1:4Ca2+ (Drosophila melanogaster)
RHEA:12896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 <=> prostaglandin E2
RHEA:17080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N-dimethylglycine + O2 <=> formaldehyde + H2O2 + sarcosine
REACT:R-CFA-6791218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Canis familiaris)
REACT:R-DDI-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Dictyostelium discoideum)
REACT:R-GGA-981814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC2 transfers sialic acid to Core 1 mucins (Gallus gallus)
REACT:R-SSC-1638821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)
REACT:R-GGA-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Gallus gallus)
REACT:R-XTR-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Xenopus tropicalis)
REACT:R-CEL-198813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO dimers reduce DeHA to AscH- (Caenorhabditis elegans)
RHEA:38823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-MMU-202459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Bcl10 (Mus musculus)
REACT:R-SSC-5634100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 dissociates from RXRA:PPARD:atRA (Sus scrofa)
RHEA:43599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde
REACT:R-BTA-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Bos taurus)
RHEA:67467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine
REACT:R-CFA-202960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of C-IAP1 (Canis familiaris)
REACT:R-SCE-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Saccharomyces cerevisiae)
GO:0005326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neurotransmitter transporter activity
GO:0005326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter transmembrane transporter activity
RHEA:65036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:51557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-glaucine + S-adenosyl-L-methionine => (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Mus musculus)
REACT:R-SSC-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Sus scrofa)
REACT:R-MMU-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Mus musculus)
REACT:R-HSA-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)
REACT:R-DDI-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:41670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chelirubine + NADPH => dihydrochelirubine + NADP(+)
RHEA:29437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin(out) + H(+)(in) => enterobactin(in) + H(+)(out)
REACT:R-XTR-3000120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLIF binds RCbl (Xenopus tropicalis)
RHEA:51940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2S)-2-methylbutanal oxime = (1Z,2S)-2-methylbutanal oxime
REACT:R-HSA-8964471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DREAM complex binds the CDC25A gene promoter (Homo sapiens)
RHEA:17974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + IMP => 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
REACT:R-BTA-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Bos taurus)
RHEA:53553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-3-acyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + a fatty acid + H(+)
REACT:R-RNO-376369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp2 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)
REACT:R-HSA-8950732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Macrophage migration inhibitory factor (Homo sapiens)
RHEA:48605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] => 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)
RHEA:40705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate
RHEA:69872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:21018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NH4(+) => H2O + L-asparagine
REACT:R-DME-209102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)
REACT:R-XTR-3321805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSL acetylates histone H4 (Xenopus tropicalis)
RHEA:30838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose
REACT:R-HSA-9749351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
GO:0102337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-cerotoyl-CoA synthase activity
RHEA:14917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-6786245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)
RHEA:10738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H(+) + NADH => a primary alcohol + NAD(+)
REACT:R-CFA-170072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Canis familiaris)
RHEA:21753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin => all-trans-capsorubin
REACT:R-MMU-8865994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds PTPN11 (Mus musculus)
REACT:R-DDI-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Dictyostelium discoideum)
REACT:R-DRE-1358792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates activated ERBB3 (Danio rerio)
REACT:R-RNO-741411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates NEMO (Rattus norvegicus)
RHEA:11830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-phospho-ribonucleotide-RNA + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O
RHEA:11504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-demethylsterigmatocystin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sterigmatocystin
RHEA:11504	skos:prefLabel	"demethylsterigmatocystin 6-O-methyltransferase"
RHEA:11504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethylsterigmatocystin 6-O-methyltransferase"
GO:0004401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidinol-phosphate phosphohydrolase activity
GO:0004401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidinol phosphate phosphatase activity
GO:0004401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidinol-phosphatase activity
GO:0004401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidinol phosphate = L-histidinol + phosphate
GO:0004401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HPpase activity
GO:0004401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histidinol-phosphatase"
GO:0004401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidinol phosphate phosphatase activity
GO:0004401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidinolphosphate phosphatase activity
GO:0004401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidinolphosphatase activity
GO:0004401	skos:prefLabel	"histidinol-phosphatase"
RHEA:24485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + sulcatol => H(+) + NADH + sulcatone
REACT:R-CFA-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Canis familiaris)
RHEA:59323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiono-1,5-lactone + H2O <=> 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)
REACT:R-SSC-8864343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD1 binds TFAP2 homo- and heterodimers (Sus scrofa)
RHEA:32940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-HSA-9654521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin dissociates KRAS4B from the plasma membrane (Homo sapiens)
REACT:R-HSA-391153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds GRB2-1 (Homo sapiens)
RHEA:29298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galacturonate(out) + H(+)(out) <=> aldehydo-D-galacturonate(in) + H(+)(in)
RHEA:69648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + quercetin 4'-O-beta-D-glucoside => beta-D-glucose + quercetin
RHEA:46349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H2O => 3-hydroxyoctanoyl-CoA
RHEA:40224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + H2O => 4,8-dimethylnonanoate + CoA + H(+)
REACT:R-SSC-5686315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Sus scrofa)
RHEA:31804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP
GO:0047840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dCTPase activity
GO:0047840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxy-CTPase activity
GO:0047840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidine-triphosphatase activity
GO:0047840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP diphosphatase activity
GO:0047840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP pyrophosphatase activity
GO:0047840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidine triphosphatase activity
GO:0047840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dCTP nucleotidohydrolase activity
REACT:R-DME-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Drosophila melanogaster)
RHEA:57738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-3,4-didehydroretinol => A + all-trans-3,4-didehydro-13,14-dihydroretinol
GO:0102916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sesamin synthase activity
REACT:R-HSA-6782443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr) (Homo sapiens)
REACT:R-HSA-201628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at DSVD (85) (Homo sapiens)
REACT:R-RNO-5358336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB forms mixed disulphides with Hh precursors (Rattus norvegicus)
REACT:R-DME-372693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BCAR1 by SRC-PTK2 complex (Drosophila melanogaster)
REACT:R-DME-4332356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK2 binds MAP3K7 (Drosophila melanogaster)
RHEA:39892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + H(+) + vancomycin
RHEA:33432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxyhexa-2,4-dienedioate => (3E)-2-oxohex-3-enedioate
REACT:R-HSA-9692129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PTGDS in testis differentiation (Homo sapiens)
REACT:R-XTR-5654408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS2 (Xenopus tropicalis)
REACT:R-DRE-182969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:CBL) (Danio rerio)
REACT:R-HSA-5654544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of overexpressed FGFR1c (Homo sapiens)
REACT:R-MMU-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Mus musculus)
RHEA:36330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate
REACT:R-BTA-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Bos taurus)
RHEA:18993	skos:prefLabel	"linoleate 11-lipoxygenase"
RHEA:18993	skos:altLabel	"linoleate dioxygenase"
RHEA:18993	skos:altLabel	"manganese lipoxygenase"
RHEA:18993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linoleate 11-lipoxygenase"
RHEA:18993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate
REACT:R-DRE-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Danio rerio)
REACT:R-MMU-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Mus musculus)
REACT:R-DDI-77584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Dictyostelium discoideum)
RHEA:44345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide A + H(+) + phosphate
RHEA:61754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + rebaudioside B + UDP => steviolbioside + UDP-alpha-D-glucose
REACT:R-XTR-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Xenopus tropicalis)
REACT:R-SSC-377640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of SRC (Sus scrofa)
RHEA:44928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoheptanedioate + acetyl-CoA + H2O = (R)-trihomocitrate + CoA + H(+)
RHEA:67403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> allo-aromadendrene + diphosphate
RHEA:36317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecan-1-ol + 2 NADP(+) => 2 H(+) + hexadecanoyl-CoA + 2 NADPH
RHEA:63507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daunorubicin + H(+) + NADPH <=> 13-dihydrodaunorubicin + NADP(+)
REACT:R-SSC-5618073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Sus scrofa)
REACT:R-RNO-982765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone forms dimers and oligomers (Rattus norvegicus)
REACT:R-CFA-6781922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds UFD1L:SKP2 (Canis familiaris)
REACT:R-DME-8877902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated AR binds RUNX2 (Drosophila melanogaster)
GO:0050069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine dehydrogenase activity
GO:0050069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)
RHEA:49284	skos:prefLabel	"8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase"
RHEA:49284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate
RHEA:49284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase"
REACT:R-XTR-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Xenopus tropicalis)
RHEA:50524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]
RHEA:58140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-AMP + cytidine(34) in elongator tRNA(Met) = AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)
REACT:R-DME-3002811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates PLK1 (Drosophila melanogaster)
REACT:R-HSA-4341016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Homo sapiens)
REACT:R-SSC-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Sus scrofa)
REACT:R-MMU-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)
REACT:R-SSC-203565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Sus scrofa)
REACT:R-GGA-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Gallus gallus)
RHEA:36410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + L-threonine <=> diphosphate + H2O + L-threonylcarbamoyladenylate
RHEA:43526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetone + CO2 + NADPH => L-allo-threonine + NADP(+)
RHEA:47034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA
REACT:R-SPO-4568863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RAD52 with SUMO1 (Schizosaccharomyces pombe)
GO:0042931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin transmembrane transporter activity
GO:0042931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterochelin transporter activity
GO:0042931	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enterobactin transporter activity
RHEA:34952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate(out) => 3-hydroxypropanoate(in)
GO:0043885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CODH
GO:0043885	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carbon monoxide dehydrogenase activity
GO:0043885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO-dehydrogenase activity
GO:0043885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-monoxide dehydrogenase (ferredoxin) activity
GO:0043885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-monoxide,water:ferredoxin oxidoreductase activity
GO:0043885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-monoxide:(acceptor) oxidoreductase activity
GO:0043885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO-dehydrogenase (ferredoxin) activity
GO:0043885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO dehydrogenase activity
GO:0043885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon monoxide dehydrogenase (ferredoxin) activity
GO:0043885	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carbon-monoxide dehydrogenase activity
REACT:R-CEL-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Caenorhabditis elegans)
REACT:R-MMU-5694442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH2,3 bind GRIA1 (Mus musculus)
REACT:R-DME-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Drosophila melanogaster)
GO:0097434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate:hydrogen symporter activity
GO:0097434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate:proton symporter activity
REACT:R-DRE-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)
RHEA:64235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O
REACT:R-CEL-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Caenorhabditis elegans)
GO:0102180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity
RHEA:61783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-tagatose <=> keto-L-sorbose
REACT:R-BTA-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Bos taurus)
RHEA:27624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate => geranylgeranyl diphosphate + 7 isopentenyl diphosphate
RHEA:55846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate
REACT:R-SSC-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Sus scrofa)
REACT:R-CFA-9605700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Canis familiaris)
REACT:R-XTR-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Xenopus tropicalis)
GO:0008788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-phosphotrehalase activity
GO:0008788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotrehalase activity
GO:0008788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose-6-phosphate hydrolase activity
GO:0008788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity
REACT:R-DRE-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Danio rerio)
REACT:R-MMU-8852481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Mus musculus)
RHEA:60887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)
REACT:R-BTA-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Bos taurus)
RHEA:11598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + UMP => H(+) + orotidine 5'-phosphate
RHEA:30645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioinosine
REACT:R-BTA-2428930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Bos taurus)
RHEA:35256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + lipid A-core(in) => ADP + H(+) + lipid A-core(out) + phosphate
REACT:R-RNO-176588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + PAPS => lithocholate sulfate + PAP (Rattus norvegicus)
RHEA:44628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroanticapsin 7-dehydrogenase"
RHEA:44628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dihydroanticapsin + NAD(+) = H(+) + L-anticapsin + NADH
RHEA:44628	skos:prefLabel	"dihydroanticapsin 7-dehydrogenase"
RHEA:16916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)
RHEA:41806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoyl-[ACP] + NADP(+) => 3-oxobutanoyl-[ACP] + H(+) + NADPH
RHEA:28893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + putrescine(out) => H(+)(in) + putrescine(in)
RHEA:71490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Leu-enkephalin <=> L-phenylalanyl-L-leucine + L-tyrosylglycylglycine
REACT:R-PFA-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Plasmodium falciparum)
RHEA:63202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10bS,4aR)-oxomaritidine + NADP(+) => (10bS,4aR)-noroxomaritidine + H(+) + NADPH
REACT:R-RNO-8876454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND3 exchanges GTP for GDP on RAB12 (Rattus norvegicus)
REACT:R-MMU-5691006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Mus musculus)
RHEA:46535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0106271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose 1-dehydrogenase (NADP+) activity
GO:0106271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arabinose 1-dehydrogenase [NAD(P)(+)]"
GO:0106271	skos:prefLabel	"D-arabinose 1-dehydrogenase [NAD(P)(+)]"
GO:0106271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose + NADP(+) = D-arabinono-1,4-lactone + H(+) + NADPH
REACT:R-DME-5654597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)
REACT:R-DRE-1168640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated IkB is degraded (Danio rerio)
RHEA:72769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+) => acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH
REACT:R-XTR-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Xenopus tropicalis)
RHEA:22098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + RNA(n) => phosphate + RNA(n+1)
REACT:R-DRE-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Danio rerio)
RHEA:23763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-CFA-2559639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV sulfilimine cross-linking by peroxidasin (Canis familiaris)
REACT:R-GGA-9664881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Gallus gallus)
REACT:R-DRE-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Danio rerio)
REACT:R-DRE-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Danio rerio)
REACT:R-MMU-3204318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Mus musculus)
EC:2.3.2.31	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RBR-type E3 ubiquitin transferase"
EC:2.3.2.31	skos:prefLabel	"RBR-type E3 ubiquitin transferase"
RHEA:43845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 => (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)
RHEA:42067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP <=> 2',3'-cGAMP + 2 diphosphate
REACT:R-CEL-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Caenorhabditis elegans)
RHEA:66798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:55725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)
REACT:R-HSA-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Homo sapiens)
REACT:R-SSC-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Sus scrofa)
RHEA:46299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-PFA-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Plasmodium falciparum)
GO:0043877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosamine-6-phosphate deaminase activity
GO:0043877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AgaI
GO:0043877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosamine-6-phosphate isomerase activity
REACT:R-SSC-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Sus scrofa)
GO:0052910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity
GO:0052910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rRNA methyltransferase ermC' activity
GO:0052910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ermC 23S rRNA methyltransferase activity
GO:0052910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rRNA:m(6)A methyltransferase ermC' activity
REACT:R-RNO-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Rattus norvegicus)
RHEA:37378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-GGA-202233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Lck by Csk (Gallus gallus)
REACT:R-MMU-4755524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1I2 with SUMO3 (Mus musculus)
RHEA:16026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA => an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA
RHEA:21405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + O2 => chlorite
GO:0030269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydromethanopterin S-methyltransferase activity
GO:0030269	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity
GO:0030269	skos:altLabel	"N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase"
GO:0030269	skos:altLabel	"tetrahydromethanopterin methyltransferase"
GO:0030269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)
GO:0030269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrahydromethanopterin S-methyltransferase"
GO:0030269	skos:prefLabel	"tetrahydromethanopterin S-methyltransferase"
GO:0030269	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity
GO:0030269	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydromethanopterin methyltransferase activity
GO:0030269	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity
GO:0102068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-humulene 10-hydroxylase activity
REACT:R-XTR-9036301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Xenopus tropicalis)
REACT:R-SSC-3134804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING ubiquitination by TRIM32 or TRIM56 (Sus scrofa)
REACT:R-DME-437230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-FGFR cis-heterodimerization (Drosophila melanogaster)
RHEA:69247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate <=> 5-methylsulfinylpentyl nitrile + sulfate + sulfur
RHEA:65516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O = NH4(+) + pre-mycofactocin
REACT:R-MMU-5654600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
REACT:R-HSA-5625123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-HSA-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Homo sapiens)
REACT:R-SPO-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Schizosaccharomyces pombe)
RHEA:47093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-dihydrodipicolinate + NADP(+) => dipicolinate + H(+) + NADPH
RHEA:71369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epiandrosterone 3-sulfate(in) + 2 Na(+)(in) => epiandrosterone 3-sulfate(out) + 2 Na(+)(out)
RHEA:14272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a quinone + H(+) + NADPH <=> 2 a 1,4-benzosemiquinone + NADP(+)
REACT:R-CFA-2201341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TRAM (TICAM2) (Canis familiaris)
REACT:R-DDI-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Dictyostelium discoideum)
RHEA:35220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dADP + H2O => 8-oxo-dAMP + H(+) + phosphate
GO:0047493	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylcholine-ceramide transferase activity
GO:0047493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide cholinephosphotransferase activity
GO:0047493	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-choline:N-acylsphingosine cholinephosphotransferase activity
REACT:R-HSA-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)
REACT:R-HSA-9684627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds CYSLTR1 antagonists (Homo sapiens)
RHEA:53024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + H2O + L-arginine = 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)
REACT:R-DRE-8955844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBKS phosphorylates ribose to R5P (Danio rerio)
GO:0080054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity nitrate transmembrane transporter activity
GO:0080054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity nitrate transmembrane transporter activity
EC:2.4.99.19	skos:prefLabel	"undecaprenyl-diphosphooligosaccharide--protein glycotransferase"
EC:2.4.99.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"undecaprenyl-diphosphooligosaccharide--protein glycotransferase"
REACT:R-GGA-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Gallus gallus)
REACT:R-RNO-1022133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)
REACT:R-DRE-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)
REACT:R-MMU-114577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Mus musculus)
REACT:R-SSC-5666160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates DIAPH2-2 at kinetochores (Sus scrofa)
RHEA:56309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Rattus norvegicus)
RHEA:22779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O2 + 2 Mn(2+) <=> 2 H2O + 2 Mn(3+)
RHEA:23512	skos:prefLabel	"alpha,alpha-trehalose phosphorylase"
RHEA:23512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + phosphate = beta-D-glucose 1-phosphate + D-glucose
RHEA:23512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha,alpha-trehalose phosphorylase"
REACT:R-BTA-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Bos taurus)
RHEA:12294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-seryl-tRNA(Ser) => ATP + L-serine + tRNA(Ser)
REACT:R-HSA-6782381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs (Homo sapiens)
RHEA:26462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine = 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Dictyostelium discoideum)
RHEA:59597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynuramine + O2 => 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)
EC:1.1.3.-	skos:prefLabel	"With oxygen as acceptor"
EC:1.1.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
REACT:R-XTR-8937442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES3 hydrolyses CHEST to CHOL and LCFA(-) (Xenopus tropicalis)
REACT:R-DME-8964280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Gq binds BTK (Drosophila melanogaster)
REACT:R-MMU-8987033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Mus musculus)
RHEA:18443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroxyindole + CO2 => D-dopachrome + H(+)
RHEA:58983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citral + H2O + O2 <=> 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2
RHEA:18981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantolactone + NADP(+) = 2-dehydropantolactone + H(+) + NADPH
EC:3.5.1.104	skos:altLabel	"N-acetylglucosamine deacetylase"
EC:3.5.1.104	skos:altLabel	"peptidoglycan GlcNAc deacetylase"
EC:3.5.1.104	skos:prefLabel	"peptidoglycan-N-acetylglucosamine deacetylase"
EC:3.5.1.104	skos:altLabel	"peptidoglycan N-acetylglucosamine deacetylase"
EC:3.5.1.104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidoglycan-N-acetylglucosamine deacetylase"
EC:3.5.1.104	skos:altLabel	"peptidoglycan deacetylase"
REACT:R-HSA-8981073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Interleukin-10 (Homo sapiens)
RHEA:52655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol + S-adenosyl-L-methionine <=> eburicol + H(+) + S-adenosyl-L-homocysteine
RHEA:39561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA
RHEA:50383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 malonyl-CoA <=> 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA
REACT:R-RNO-1250353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Rattus norvegicus)
RHEA:57212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-dGTP
REACT:R-DRE-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Danio rerio)
REACT:R-HSA-170044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Homo sapiens)
RHEA:18475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + ATP => 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
RHEA:69557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + H(+)(out) => D-glucose(in) + H(+)(in)
RHEA:71855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurochenodeoxycholate(out) = taurochenodeoxycholate(in)
REACT:R-GGA-1297444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of cAMP to HCN channels (Gallus gallus)
REACT:R-GGA-8987080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Gallus gallus)
GO:0018623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoic hydroxylase activity
GO:0018623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)
GO:0018623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate hydroxylase activity
GO:0018623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)
GO:0018623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate 1,2-dioxygenase activity
GO:0018623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate dioxygenase activity
RHEA:67001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisobutanophenone
REACT:R-HSA-5358599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Homo sapiens)
RHEA:16546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + oxalate => formate + oxalyl-CoA
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)+:L-arginine ADP-D-ribosyltransferase activity
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ADP-ribosyltransferase activity
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine ADP-ribosyltransferase activity
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+):L-arginine ADP-D-ribosyltransferase activity
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP+-protein-arginine ADP-ribosyltransferase activity
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-arginine ADP-ribosylation activity
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)(+)--arginine ADP-ribosyltransferase activity
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	mono(ADP-ribosyl)transferase activity
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity
GO:0106274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-protein-arginine ADP-ribosyltransferase activity
REACT:R-SSC-9014424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the phagocytic vesicle membrane (Sus scrofa)
REACT:R-BTA-2022141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolysyl oxidase activation (Bos taurus)
REACT:R-GGA-5694126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C3B hydrolyses 7MGP to 7MG (Gallus gallus)
REACT:R-XTR-77614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR1) (Xenopus tropicalis)
RHEA:33740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoate + NADH => H2O + hexadecanal + NAD(+)
RHEA:25049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)
REACT:R-CEL-9695890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:48663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diapophytofluene + FADH2 => 15-cis-4,4'-diapophytoene + FAD + H(+)
RHEA:69576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+) = (R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2
RHEA:28698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(in) <=> hydrogencarbonate(out)
REACT:R-DRE-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Danio rerio)
RHEA:65058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxoglycolithocholate + H(+) + NADPH => glycochenodeoxycholate + NADP(+)
REACT:R-BTA-5661122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2R3-histone H3 (Bos taurus)
REACT:R-CFA-8964604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Canis familiaris)
REACT:R-MMU-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Mus musculus)
RHEA:27896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + phosphate => 3'-CMP + H2O
REACT:R-CEL-3858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL recruits RAC (Caenorhabditis elegans)
REACT:R-RNO-6804276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TTC5 (Rattus norvegicus)
REACT:R-BTA-5689630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BAP1-interacting complex (Bos taurus)
REACT:R-BTA-5205861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Bos taurus)
REACT:R-DRE-3301943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTK1 dimer transfers GS from GSH to CDNB (Danio rerio)
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonucleate polymerase activity
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonucleic transcriptase activity
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribonucleic acid nucleotidyltransferase
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transcriptase
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonucleic acid transcriptase activity
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonucleic polymerase activity
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C ribonucleic acid formation factors
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonucleic acid polymerase activity
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA polymerase activity
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-3' RNA polymerase activity
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA transcriptase activity
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA nucleotidyltransferase activity
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C RNA formation factors
GO:0034062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonucleate nucleotidyltransferase activity
RHEA:35898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-HSA-8985138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAS2 binds viral dsRNA (Homo sapiens)
RHEA:72946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + pyruvate(out) <=> 2 Na(+)(in) + pyruvate(in)
REACT:R-SSC-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Sus scrofa)
REACT:R-DRE-8964246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in G alpha (12)-BTK complex is activated (Danio rerio)
REACT:R-BTA-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Bos taurus)
RHEA:60373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose(out) => D-fructose(in)
RHEA:21817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)
REACT:R-HSA-1592232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TFB1M (Homo sapiens)
RHEA:34965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) => Na(+)(in)
REACT:R-DME-1602368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Drosophila melanogaster)
REACT:R-BTA-4719423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO3 (Bos taurus)
REACT:R-HSA-2318585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HYAL1 does not hydrolyse Chondroitin chains (Homo sapiens)
REACT:R-HSA-9018499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and EP300 are recruited to TFF3 promoter (Homo sapiens)
REACT:R-CFA-937032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
REACT:R-DRE-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Danio rerio)
REACT:R-BTA-927832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)
REACT:R-GGA-419351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF receptor binds platelet activating factor (Gallus gallus)
GO:0140319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decoy receptor
GO:0140319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor decoy activity
GO:0140319	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	decoy death receptor activity
REACT:R-DME-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Drosophila melanogaster)
RHEA:65178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + protoaustinoid B => A + protoaustinoid A
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	procollagen galactosyltransferase activity
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	collagen galactosyltransferase activity
GO:0050211	skos:prefLabel	"procollagen galactosyltransferase"
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP
GO:0050211	skos:altLabel	"hydroxylysine galactosyltransferase"
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP galactose-collagen galactosyltransferase activity
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylysine galactosyltransferase activity
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"procollagen galactosyltransferase"
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	collagen hydroxylysyl galactosyltransferase activity
GO:0050211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-collagen galactosyltransferase activity
RHEA:37634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-CFA-389756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT interacts and phosphorylates Cot (Canis familiaris)
REACT:R-SSC-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Sus scrofa)
RHEA:58108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]
GO:0070748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-35 receptor binding
GO:0070748	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-35 receptor ligand
GO:0070748	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-35
RHEA:52692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenyllactate + NADP(+) = 3-phenylpyruvate + H(+) + NADPH
REACT:R-CFA-5602295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)
REACT:R-DRE-388833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CTLA-4 (Danio rerio)
REACT:R-HSA-6803914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the RGCC gene (Homo sapiens)
RHEA:57929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate
RHEA:50832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate
REACT:R-HSA-3857345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CEBPB binds CDKN2B promoter (Homo sapiens)
REACT:R-CFA-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Canis familiaris)
RHEA:15552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate <=> 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O
REACT:R-XTR-8850356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds microbial lipid-based antigen via CD1 (Xenopus tropicalis)
REACT:R-PFA-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Plasmodium falciparum)
RHEA:53708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + NADP(+) = (2E,4Z)-decadienoyl-CoA + H(+) + NADPH
RHEA:17521	skos:altLabel	"glutamyl-tRNA(Gln) amidotransferase"
RHEA:17521	skos:altLabel	"Glu-AdT"
RHEA:17521	skos:prefLabel	"glutaminyl-tRNA synthase (glutamine-hydrolyzing)"
RHEA:17521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate
RHEA:17521	skos:altLabel	"GatFAB"
RHEA:17521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutaminyl-tRNA synthase (glutamine-hydrolyzing)"
RHEA:17521	skos:altLabel	"GatDE"
RHEA:17521	skos:altLabel	"Glu-tRNA(Gln) amidotransferase"
RHEA:17521	skos:altLabel	"GatCAB"
REACT:R-CEL-429698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKD1,2,3 phosphorylates CERT1-2 (Caenorhabditis elegans)
RHEA:23224	skos:altLabel	"zeatin O-beta-D-glucosyltransferase"
RHEA:23224	skos:prefLabel	"trans-zeatin O-beta-D-glucosyltransferase"
RHEA:23224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-trans-zeatin + UDP
RHEA:23224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-zeatin O-beta-D-glucosyltransferase"
RHEA:23224	skos:altLabel	"zeatin O-glucosyltransferase"
RHEA:23224	skos:altLabel	"uridine diphosphoglucose-zeatin O-glucosyltransferase"
RHEA:11666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate
GO:0004827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline-tRNA ligase activity
GO:0004827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-proline:tRNAPro ligase (AMP-forming)
GO:0004827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prolyl-tRNA synthetase activity
GO:0004827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prolyl-transferRNA synthetase activity
GO:0004827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prolyl-transfer ribonucleic acid synthetase activity
GO:0004827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prolinyl-tRNA ligase activity
GO:0004827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prolyl-s-RNA synthetase activity
GO:0004827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prolyl-transfer ribonucleate synthetase activity
GO:0004827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proline translase activity
REACT:R-XTR-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Xenopus tropicalis)
REACT:R-DRE-977629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of C2a/Bb by CR1 (Danio rerio)
REACT:R-DDI-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Dictyostelium discoideum)
RHEA:36804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2,3-dihydrogenistein => genistein + H(+) + H2O
REACT:R-BTA-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Bos taurus)
REACT:R-BTA-5252072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AZGP1 binds PIP (Bos taurus)
REACT:R-DRE-5683801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates BRCA1 (Danio rerio)
GO:0140953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K27 monomethylase activity
GO:0140953	skos:prefLabel	"[histone H3]-lysine(27) N-methyltransferase"
GO:0140953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine
GO:0140953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-monomethyltransferase activity (H3-K27 specific)
GO:0140953	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K27 methylation
GO:0140953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(27) N-methyltransferase"
GO:0140953	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K27 methylation
GO:0140953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 monomethylase activity
GO:0140953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 monomethyltransferase activity
REACT:R-MMU-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Mus musculus)
RHEA:58037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => 8-epi-inunolide + H2O
RHEA:11999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2-ol + H(+) + NADH + O2 <=> biphenyl-2,3-diol + H2O + NAD(+)
RHEA:66599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 2 tyramine <=> 2 dopamine
GO:0102898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	levopimaradienol hydroxylase activity
EC:1.14.14.87	skos:altLabel	"isoflavonoid synthase"
EC:1.14.14.87	skos:prefLabel	"2-hydroxyisoflavanone synthase"
EC:1.14.14.87	skos:altLabel	"CYT93C"
EC:1.14.14.87	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyisoflavanone synthase"
RHEA:63140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoyl-taurine = taurine + tetracosanoate
REACT:R-HSA-844620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dsDNA:AIM2 clusters bind ASC (Homo sapiens)
RHEA:36315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+)
RHEA:70215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + H(+) + NADPH = 20beta-dihydrocortisol + NADP(+)
REACT:R-RNO-8853965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Rattus norvegicus)
GO:0003916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA topoisomerase activity
REACT:R-CEL-1234183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)
REACT:R-DRE-2404131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Danio rerio)
REACT:R-SCE-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Saccharomyces cerevisiae)
REACT:R-GGA-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Gallus gallus)
REACT:R-PFA-352052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Plasmodium falciparum)
RHEA:38451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfide dehydrogenase"
RHEA:38451	skos:prefLabel	"sulfide dehydrogenase"
RHEA:38451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + NADP(+) + n sulfur = NADPH + (n+1) sulfur
RHEA:18641	skos:altLabel	"hydrogen:menaquinone oxidoreductase"
RHEA:18641	skos:altLabel	"hydrogen-ubiquinone oxidoreductase"
RHEA:18641	skos:prefLabel	"hydrogen:quinone oxidoreductase"
RHEA:18641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrogen:quinone oxidoreductase"
RHEA:18641	skos:altLabel	"membrane-bound hydrogenase"
RHEA:18641	skos:altLabel	"quinone-reactive Ni/Fe-hydrogenase"
RHEA:18641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H2 = a menaquinol
REACT:R-HSA-114577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
RHEA:35600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADPH
RHEA:39783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroferuloyl-CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH
RHEA:42109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone
RHEA:40430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-GGA-5665802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Gallus gallus)
REACT:R-RNO-1369052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid influx (Rattus norvegicus)
REACT:R-DDI-389995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Dictyostelium discoideum)
REACT:R-DRE-8851038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 binds prenylated phosphoantigens (Danio rerio)
REACT:R-RNO-1433418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Rattus norvegicus)
RHEA:63936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX
REACT:R-MMU-2467665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds Beta amyloid fibril via GAG chains (Mus musculus)
REACT:R-PFA-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Plasmodium falciparum)
RHEA:12161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-gluconate + NAD(+) => 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH
REACT:R-HSA-870269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gastrin binds to CCK-B receptor (Homo sapiens)
REACT:R-RNO-176646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Rattus norvegicus)
RHEA:43984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)
REACT:R-CFA-196026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dab2 is recruited to the junctional plaques (Canis familiaris)
REACT:R-CFA-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Canis familiaris)
GO:0102603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-demethyl-elloramycin C12a O-methyltransferase activity
RHEA:40858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + undecanoyl-CoA <=> FADH2 + trans-2-undecenoyl-CoA
REACT:R-SSC-418170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB1 binds MAPKs, SRC-1 (Sus scrofa)
RHEA:12051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate + succinyl-CoA <=> 3-oxoadipyl-CoA + succinate
RHEA:34906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 glutathione + 2 H(+) + selenite <=> glutathione disulfide + 3 H2O + selenodiglutathione
RHEA:33715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyeicosasphinganine 1-phosphate = 2-hydroxyoctadecanal + phosphoethanolamine
REACT:R-RNO-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Rattus norvegicus)
RHEA:19744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + H2O <=> CoA + formate + H(+)
RHEA:38854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + tetracenomycin F2 <=> H2O + tetracenomycin F1
RHEA:38720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + ATP + H2O => (R)-carnitine(in) + ADP + H(+) + phosphate
RHEA:59383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxyprephenate + NAD(+) <=> 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH
REACT:R-DRE-4085133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUM (lumican) binds integrin alpha2beta1 (Danio rerio)
GO:0055103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase regulator activity
REACT:R-GGA-5358336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB forms mixed disulphides with Hh precursors (Gallus gallus)
REACT:R-HSA-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Homo sapiens)
REACT:R-MMU-1112690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds CBL (Mus musculus)
RHEA:28686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + ubiquinone-8 <=> iminosuccinate + ubiquinol-8
REACT:R-SSC-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Sus scrofa)
REACT:R-RNO-2130641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TGN-lysosome vesicle to lysosome (Rattus norvegicus)
RHEA:29090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + menaquinone-8 <=> menaquinol-8 + oxaloacetate
REACT:R-XTR-9645442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Xenopus tropicalis)
REACT:R-HSA-9681763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1 binds IL1R1 inhibitors (Homo sapiens)
RHEA:61899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone C <=> betaenone A
REACT:R-SSC-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Sus scrofa)
RHEA:46787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-216727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Canis familiaris)
REACT:R-RNO-9712210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Rattus norvegicus)
REACT:R-GGA-5229273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCN2:2,5DHBA binds Fe3+ (Gallus gallus)
RHEA:16376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate + ATP <=> (R)-4'-phosphopantothenate + ADP + H(+)
REACT:R-CFA-8875816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds activated MET receptor (Canis familiaris)
REACT:R-CEL-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Caenorhabditis elegans)
RHEA:49372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protodeoxyviolaceinate = H2O + NAD(+) + protoviolaceinate
REACT:R-SSC-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Sus scrofa)
REACT:R-MMU-9690494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB translocates to the endosome membrane (Mus musculus)
REACT:R-SSC-9756177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse ATVL to ATV (Sus scrofa)
RHEA:68352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pppA(2'-5')pG = 3',2'-cGAMP + diphosphate
REACT:R-GGA-4332356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK2 binds MAP3K7 (Gallus gallus)
RHEA:52622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dimethylpropanoyl-CoA => 3-methylbutanoyl-CoA
REACT:R-DRE-139909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BMF to mitochondria (Danio rerio)
RHEA:24872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + adenine
REACT:R-MMU-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Mus musculus)
REACT:R-HSA-9630795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)
REACT:R-MMU-2574840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA facilitates AURKA autophosphorylation (Mus musculus)
REACT:R-HSA-5228941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcytosis and dissociation of botE:NTNHA (Homo sapiens)
REACT:R-MMU-141351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAOX:FAD oxidises NASPN to SPM (Mus musculus)
RHEA:18794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate => D-ribose 5-phosphate
RHEA:12529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate => [hyaluronan](n+1) + H(+) + UDP
GO:0047163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dichloroaniline N-malonyltransferase activity
GO:0047163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity
REACT:R-GGA-1112666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Gallus gallus)
GO:0061547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Homo sapiens)
GO:0061547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen synthase activity, transferring glucose-1-phosphate
GO:0061547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Homo sapiens)
REACT:R-HSA-549493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PERIOD-2 (Homo sapiens)
RHEA:10481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxy-L-glutamate => 4-hydroxy-2-oxoglutarate + L-glutamate
RHEA:16182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Sus scrofa)
REACT:R-HSA-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Homo sapiens)
RHEA:31922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-390329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of AKT by PP2A (Danio rerio)
REACT:R-DRE-2230938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin:Haptoglobin:CD163 is endocytosed (Danio rerio)
REACT:R-HSA-981814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC2 transfers sialic acid to Core 1 mucins (Homo sapiens)
RHEA:69941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase]
GO:0047013	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	12-alpha-hydroxysteroid dehydrogenase activity
GO:0047013	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP-12alpha-hydroxysteroid dehydrogenase activity
GO:0047013	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity
GO:0047013	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	12alpha-hydroxy steroid dehydrogenase activity
GO:0047013	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	12alpha-hydroxysteroid dehydrogenase activity
GO:0047013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate 12-alpha dehydrogenase activity
GO:0047013	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity
REACT:R-XTR-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)
REACT:R-RNO-193460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Rattus norvegicus)
REACT:R-CFA-1855202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Canis familiaris)
REACT:R-DRE-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Danio rerio)
REACT:R-BTA-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Bos taurus)
REACT:R-DRE-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Danio rerio)
REACT:R-DME-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)
RHEA:45402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:38877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(2604) in 23S rRNA => uridine(2604) in 23S rRNA
REACT:R-DRE-2731122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2 & 4 bind VTN (Danio rerio)
REACT:R-DME-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Drosophila melanogaster)
REACT:R-DME-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Drosophila melanogaster)
REACT:R-DRE-193694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 is recruited and forms a complex with TRAF6 (Danio rerio)
GO:0110050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deaminated glutathione amidase activity
GO:0110050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-oxoglutaryl)-L-cysteinylglycine = 2-oxoglutarate + L-cysteinylglycine
GO:0110050	skos:altLabel	"dGSH deaminase"
GO:0110050	skos:prefLabel	"deaminated glutathione amidase"
GO:0110050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deaminated glutathione amidase"
REACT:R-CFA-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Canis familiaris)
RHEA:70954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine + H2O + O2 <=> 3-hydroxypyruvate + H2O2 + NH4(+)
RHEA:56247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]
REACT:R-HSA-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Homo sapiens)
RHEA:52424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP
RHEA:66596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 2 tyramine = 2 dopamine
RHEA:33417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+) => bornane-2,6-dione + H2O
RHEA:16512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxalate <=> CO2 + formate
REACT:R-RNO-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Rattus norvegicus)
REACT:R-RNO-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)
REACT:R-HSA-4827382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)
REACT:R-CFA-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Canis familiaris)
REACT:R-DRE-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Danio rerio)
REACT:R-RNO-199910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates ATF1 (Rattus norvegicus)
RHEA:56417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => alpha-D-glucose 1-phosphate + glycerol
REACT:R-HSA-173488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
RHEA:41431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + S-adenosyl-L-methionine <=> 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Mus musculus)
RHEA:61986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + ubiquinol-10 => H(+) + NADH + ubiquinone-10
GO:0019768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity IgE receptor activity
GO:0019768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	high affinity Fc receptor activity
GO:0019768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity IgE receptor activity
REACT:R-MMU-2730876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IKK-beta by TAK1 (Mus musculus)
REACT:R-BTA-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Bos taurus)
RHEA:59877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoate + ATP + L-cysteine => (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)
REACT:R-CFA-5218847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 binds NCK (Canis familiaris)
REACT:R-RNO-202721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 binds JAM3 (Rattus norvegicus)
REACT:R-BTA-159757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)
RHEA:13391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein] => glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein]
RHEA:36800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + H2O => a ribonucleoside 5'-phosphate + H(+) + phosphate
RHEA:35448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S)-averantin + NADP(+) => H(+) + NADPH + norsolorinic acid
RHEA:34894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenite(in) <=> selenite(out)
RHEA:50062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycochenodeoxycholate(out) + H(+) + phosphate => ATP + glycochenodeoxycholate(in) + H2O
RHEA:40872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + FAD + H(+) => (2E,9Z)-octadecadienoyl-CoA + FADH2
REACT:R-BTA-427527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC dimethylates histone H3 at lysine-9 (Bos taurus)
GO:0000225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcNAc-PI de-N-acetylase activity
GO:0000225	skos:altLabel	"GlcNAc-PI deacetylase"
GO:0000225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol
GO:0000225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosaminylphosphatidylinositol deacetylase"
GO:0000225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcNAc-PI deacetylase activity
GO:0000225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglucosaminylphosphatidylinositol deacetylase activity
GO:0000225	skos:altLabel	"N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase"
GO:0000225	skos:altLabel	"N-acetylglucosaminylphosphatidylinositol de-N-acetylase"
GO:0000225	skos:altLabel	"GlcNAc-PI de-N-acetylase"
GO:0000225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity
GO:0000225	skos:altLabel	"acetylglucosaminylphosphatidylinositol deacetylase"
GO:0000225	skos:prefLabel	"N-acetylglucosaminylphosphatidylinositol deacetylase"
GO:0000225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminylphosphatidylinositol deacetylase activity
GO:0000225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity
GO:0000225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity
REACT:R-CFA-1297333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Acrosin Heavy and Light Chain (Canis familiaris)
REACT:R-CFA-909552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 at Ser727 (Canis familiaris)
REACT:R-CFA-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Canis familiaris)
REACT:R-XTR-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Xenopus tropicalis)
RHEA:51843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauroallocholate(out) <=> 2 Na(+)(in) + tauroallocholate(in)
RHEA:68183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty acyl-CoA + H2O <=> a short-chain fatty acid + CoA + H(+)
RHEA:63856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecanoate = (2R)-2-hydroperoxytetradecanoate
RHEA:48332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
REACT:R-XTR-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Xenopus tropicalis)
REACT:R-RNO-9007283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 and PRC1.6 associate with E2F6.com-1 (Rattus norvegicus)
RHEA:29214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + inosine(in) <=> H(+)(in) + inosine(out)
REACT:R-DME-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Drosophila melanogaster)
REACT:R-RNO-1592297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full activation of MMP1 (Rattus norvegicus)
REACT:R-XTR-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Xenopus tropicalis)
REACT:R-DME-9624526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Drosophila melanogaster)
RHEA:71258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + phosphate(out) <=> 3 Na(+)(in) + phosphate(in)
RHEA:69384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) = (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]
RHEA:36262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(1-hydroxyalkyl)-sn-glycerol <=> an aldehyde + glycerol
RHEA:68477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroperoxy fatty acid + H(+) => a fatty aldehyde + CO2 + H2O
REACT:R-XTR-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Xenopus tropicalis)
RHEA:72047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline = AH2 + fusahexin + 6 H2O
EC:1.1.1.60	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-3-oxopropionate reductase"
EC:1.1.1.60	skos:altLabel	"tartronate semialdehyde reductase"
EC:1.1.1.60	skos:prefLabel	"2-hydroxy-3-oxopropionate reductase"
REACT:R-SSC-76426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-atom dealkylation of caffeine (Sus scrofa)
GO:0018731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-oxa-2-oxocycloheptane lactonase activity
RHEA:58114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ADP-D-ribose + H(+) => 1''-O-acetyl-ADP-alpha-D-ribose + H2O
GO:0052691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-arabinopyranose pyranomutase activity
GO:0052691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-arabinopyranose mutase activity
GO:0052691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-L-arabinose mutase activity
GO:0052691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-L-Ara mutase activity
GO:0052691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine-diphosphate-L-arabinose mutase activity
GO:0052691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-L-arabinopyranose furanomutase activity
REACT:R-CFA-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Canis familiaris)
REACT:R-GGA-2562594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated OPTN translocates to the nucleus (Gallus gallus)
RHEA:50254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxoacyl-CoA + CO2 + CoA => an acyl-CoA + H(+) + malonyl-CoA
REACT:R-MMU-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)
RHEA:51914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate
REACT:R-DME-71335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)
REACT:R-MMU-9034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 dimers trans-autophosphorylate (Mus musculus)
GO:0043225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled anion transmembrane transporter activity
GO:0043225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Homo sapiens)
GO:0043225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anion-transporting ATPase activity
GO:0043225	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	anion ABC transporter
GO:0043225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled inorganic anion transmembrane transporter activity
GO:0043225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent anion transmembrane transporter activity
GO:0043225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anion transmembrane-transporting ATPase activity
GO:0043225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCC6 does not transport organic anion from cytosol to extracellular region (Homo sapiens)
REACT:R-DRE-8853745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA3 (Danio rerio)
REACT:R-HSA-983148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Erp57 with MHC class I HC (Homo sapiens)
REACT:R-SSC-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Sus scrofa)
RHEA:12911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome] + H2O + nitrite => 2 Fe(II)-[cytochrome] + 2 H(+) + nitrate
REACT:R-BTA-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Bos taurus)
RHEA:25867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine
EC:3.4.21.81	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"streptogrisin B"
EC:3.4.21.81	skos:altLabel	"SGPB"
EC:3.4.21.81	skos:altLabel	"Streptomyces protease B"
EC:3.4.21.81	skos:altLabel	"pronase enzyme B"
EC:3.4.21.81	skos:prefLabel	"streptogrisin B"
REACT:R-MMU-139898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 activates BID by cleavage (Mus musculus)
REACT:R-MMU-8987132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Mus musculus)
REACT:R-MMU-997237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B proteins bind JAK2 (Mus musculus)
REACT:R-BTA-3222259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF20 binds TP53 dimethylated on K370 and K382 (Bos taurus)
REACT:R-HSA-168858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmitoylation of cysteine residues on HA in the cis-Golgi network (Homo sapiens)
RHEA:65726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + pentanal + succinate + sulfate => 2-oxoglutarate + O2 + pentyl sulfate
RHEA:29080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + ubiquinone-8 => pyruvate + ubiquinol-8
RHEA:30768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucurono-3,6-lactone + H2O => D-glucuronate + H(+)
REACT:R-HSA-2172194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) (Homo sapiens)
REACT:R-SSC-9021596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane estrogen receptors bind SRC (Sus scrofa)
RHEA:37837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epsilon-rhodomycinone + H2O + NADP(+) => aklavinone + H(+) + NADPH + O2
REACT:R-CFA-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Canis familiaris)
EC:3.2.1.144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxyoctulosonase"
EC:3.2.1.144	skos:altLabel	"alpha-Kdo-ase"
EC:3.2.1.144	skos:prefLabel	"3-deoxyoctulosonase"
RHEA:61853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesterol + UDP-alpha-D-glucose => campesteryl 3-beta-D-glucoside + H(+) + UDP
RHEA:40628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trihexadecanoylglycerol => 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate
REACT:R-SPO-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Schizosaccharomyces pombe)
RHEA:20628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c3] + H2 <=> 2 Fe(II)-[cytochrome c3] + 2 H(+)
REACT:R-XTR-5323545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canonical WNT signaling through the atypical receptor RYK (Xenopus tropicalis)
REACT:R-GGA-8855111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds PCSK9 (Gallus gallus)
REACT:R-CEL-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Caenorhabditis elegans)
RHEA:72954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) + 2 Na(+)(out) <=> butanoate(in) + 2 Na(+)(in)
RHEA:58398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin]
EC:1.1.1.82	skos:prefLabel	"malate dehydrogenase (NADP(+))"
EC:1.1.1.82	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malate dehydrogenase (NADP(+))"
EC:1.1.1.82	skos:altLabel	"NADP-linked malate dehydrogenase"
REACT:R-GGA-195408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Gallus gallus)
RHEA:64603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base
REACT:R-HSA-2485182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Homo sapiens)
RHEA:49405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate => alpha-D-mannose 1-phosphate + D-mannose
RHEA:66078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine
GO:0098599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl hydrolase activity
REACT:R-MMU-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Mus musculus)
REACT:R-MMU-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Mus musculus)
REACT:R-HSA-5667052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROPN1 binds RHOA:GTP:RHPN1 (Homo sapiens)
REACT:R-XTR-437230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-FGFR cis-heterodimerization (Xenopus tropicalis)
REACT:R-HSA-1168641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)
REACT:R-HSA-8864036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)
REACT:R-RNO-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Rattus norvegicus)
REACT:R-BTA-177939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
REACT:R-XTR-5654631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PPTN11 (Xenopus tropicalis)
REACT:R-MMU-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Mus musculus)
REACT:R-XTR-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Xenopus tropicalis)
REACT:R-HSA-379864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)
REACT:R-BTA-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)
REACT:R-MMU-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Mus musculus)
RHEA:56487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Homo sapiens)
RHEA:54585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in 18S rRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine
REACT:R-SSC-2514867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Sus scrofa)
REACT:R-DRE-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Danio rerio)
RHEA:65611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + docosanoyl-CoA <=> CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine
RHEA:39339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)
REACT:R-SSC-6781899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds SIAH2 (Sus scrofa)
REACT:R-XTR-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Xenopus tropicalis)
RHEA:51836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
RHEA:40181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + H2O2 => decanoyl-CoA + O2
REACT:R-MMU-6811423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Mus musculus)
RHEA:56152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Homo sapiens)
REACT:R-MMU-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)
REACT:R-CFA-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Canis familiaris)
RHEA:67914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid => [protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O
REACT:R-GGA-9707523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to BACH1:MAFK (Gallus gallus)
REACT:R-CFA-5358343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT palmitoylates Hh N-terminal fragment (Canis familiaris)
REACT:R-GGA-1678998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosomal TLRs pass through the Golgi (Gallus gallus)
REACT:R-RNO-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
REACT:R-SPO-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Schizosaccharomyces pombe)
REACT:R-HSA-2404195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Homo sapiens)
REACT:R-SSC-8852509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL-LK binds carbohydrates on target cell surface (Sus scrofa)
REACT:R-XTR-6806647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)
RHEA:54655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peregrinol diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O
REACT:R-HSA-9026544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Non-enzymatic hydrolysis hydrolyses 13(S),14(S)-epoxy-DHA to 7-epi-MaR1 (Homo sapiens)
REACT:R-CEL-389632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)
RHEA:69750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + succinyl-CoA <=> (indol-3-yl)acetyl-CoA + succinate
REACT:R-DRE-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Danio rerio)
REACT:R-RNO-5668947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates myosin phosphatase (Rattus norvegicus)
REACT:R-CEL-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Caenorhabditis elegans)
RHEA:52501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-6786650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDHD1,2 hydrolyse PA (Danio rerio)
RHEA:19117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dopamine beta-monooxygenase"
RHEA:19117	skos:prefLabel	"dopamine beta-monooxygenase"
RHEA:19117	skos:altLabel	"dopamine beta-hydroxylase"
RHEA:19117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical
RHEA:19117	skos:altLabel	"(3,4-dihydroxyphenethylamine)beta-monooxygenase"
RHEA:62734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isomalbrancheamide D + FADH2 => (+)-isomalbrancheamide B + bromide + FAD + 2 H(+)
RHEA:23729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 => A + H2O + prostaglandin H2
REACT:R-DRE-5682965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Danio rerio)
REACT:R-RNO-1222491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoferrin scavenges iron ions (Rattus norvegicus)
REACT:R-SCE-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Saccharomyces cerevisiae)
REACT:R-HSA-2534040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown NAT N-acylates Gly in GNAT1 (Homo sapiens)
GO:0033677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent DNA/RNA helicase activity
GO:0033677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA/RNA helicase activity
REACT:R-HSA-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Homo sapiens)
REACT:R-GGA-165708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated 4EBP1 from eIF4E (Gallus gallus)
REACT:R-DRE-8847995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERBB2 binds PTK6 (BRK) (Danio rerio)
REACT:R-DDI-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Dictyostelium discoideum)
RHEA:36788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
REACT:R-BTA-83803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Bos taurus)
RHEA:49022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one
RHEA:22627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxy-2-oxopentanoate <=> acetaldehyde + pyruvate
REACT:R-DME-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Drosophila melanogaster)
RHEA:16111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate
RHEA:51574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-RNO-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Rattus norvegicus)
RHEA:64526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] => (2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA
REACT:R-CFA-1971482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Canis familiaris)
RHEA:63780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine
REACT:R-DME-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Drosophila melanogaster)
RHEA:46407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-8871373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMX phosphorylates RUFY1 (Mus musculus)
REACT:R-MMU-5654701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
REACT:R-XTR-8933452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE dimer binds phosphorylated DENND1 proteins (Xenopus tropicalis)
RHEA:14863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + orotate => (S)-dihydroorotate + NADP(+)
REACT:R-MMU-873919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Mus musculus)
REACT:R-DME-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Drosophila melanogaster)
REACT:R-RNO-5651789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to POLB ligates SSB (Rattus norvegicus)
REACT:R-RNO-8987012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)
REACT:R-DRE-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)
REACT:R-SSC-9012036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)
REACT:R-BTA-181450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Bos taurus)
RHEA:40519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:46119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-galactonate <=> D-glyceraldehyde + pyruvate
REACT:R-RNO-8987040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Rattus norvegicus)
REACT:R-HSA-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Homo sapiens)
GO:0050203	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalyl coenzyme A synthetase activity
GO:0050203	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalyl-CoA synthetase activity
GO:0050203	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalate:CoA ligase (AMP-forming)
GO:0050203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate-CoA ligase activity
REACT:R-SSC-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Sus scrofa)
RHEA:61651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[non-ribosomal peptide synthase] + salicylate <=> AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]
REACT:R-CFA-109759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Canis familiaris)
RHEA:56883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-Delta(5)-steroid + NADP(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADPH
RHEA:21905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + H2O => (2R)-3-phosphoglycerate + phosphate
REACT:R-BTA-205262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Direct recruitment of PI3K to p-KIT (Bos taurus)
RHEA:67487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP
REACT:R-SSC-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Sus scrofa)
GO:0061686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hercynylcysteine sulfoxide synthase
GO:0061686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hercynine + L-cysteine + O2 = H2O + S-(hercyn-2-yl)-L-cysteine S-oxide
GO:0061686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hercynylcysteine S-oxide synthase"
GO:0061686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hercynylcysteine sulfoxide synthase activity
GO:0061686	skos:prefLabel	"hercynylcysteine S-oxide synthase"
GO:0061686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hercynylcysteine S-oxide synthase
REACT:R-MMU-5684865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB dimer,C translocate from multivesicle body to lamellar body (Mus musculus)
RHEA:69064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 = H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline
RHEA:53001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:52768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O = 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate
REACT:R-HSA-9640254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Homo sapiens)
RHEA:10050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + L-methionine => methanethiol + O-acetyl-L-homoserine
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartic protease activity involved in amyloid precursor protein breakdown
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic endopeptidase activity involved in APP catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartyl protease activity involved in APP catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carboxyl protease activity involved in amyloid precursor protein degradation
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartic protease activity involved in APP catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic endopeptidase activity involved in APP catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carboxyl protease activity involved in amyloid precursor protein catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartic protease activity involved in amyloid precursor protein degradation
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartyl protease activity involved in APP catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartate protease activity involved in APP catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic-type endopeptidase activity involved in APP catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartyl protease activity involved in amyloid precursor protein degradation
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carboxyl protease activity involved in amyloid precursor protein catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carboxyl protease activity involved in amyloid precursor protein breakdown
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic endopeptidase activity involved in amyloid precursor protein breakdown
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartate protease activity involved in amyloid precursor protein catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartic protease activity involved in amyloid precursor protein catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic-type endopeptidase activity involved in amyloid precursor protein degradation
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartic protease activity involved in APP catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartate protease activity involved in amyloid precursor protein degradation
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartic protease activity involved in amyloid precursor protein catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartyl protease activity involved in amyloid precursor protein catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic-type endopeptidase activity involved in APP catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartate protease activity involved in APP catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic endopeptidase activity involved in amyloid precursor protein catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic endopeptidase activity involved in amyloid precursor protein degradation
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carboxyl protease activity involved in APP catabolic process
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartyl protease activity involved in amyloid precursor protein breakdown
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartyl protease activity involved in amyloid precursor protein catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartate protease activity involved in amyloid precursor protein breakdown
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carboxyl protease activity involved in APP catabolism
GO:1902944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartate protease activity involved in amyloid precursor protein catabolism
REACT:R-CFA-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Canis familiaris)
REACT:R-HSA-9694445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 binds nsp10 (Homo sapiens)
REACT:R-DME-351849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Etk (Drosophila melanogaster)
REACT:R-HSA-5617179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates TNNI3 (Homo sapiens)
REACT:R-BTA-9678561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Bos taurus)
REACT:R-RNO-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Rattus norvegicus)
REACT:R-RNO-5690245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 binds DNAJB1 (Rattus norvegicus)
REACT:R-BTA-9020274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Bos taurus)
REACT:R-BTA-264458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of COP1 (Bos taurus)
RHEA:15720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daunorubicin + H(+) + NADPH + O2 <=> doxorubicin + H2O + NADP(+)
RHEA:11947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)
REACT:R-DME-5324617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:FKBP4:PTGES3 binds HSF1 trimer (Drosophila melanogaster)
REACT:R-XTR-5218640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates p-Y397-PTK2 (Xenopus tropicalis)
REACT:R-HSA-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)
REACT:R-HSA-391937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP/CysLT receptor can bind cysteinyl leukotrienes (Homo sapiens)
REACT:R-HSA-9027631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA (Homo sapiens)
REACT:R-CEL-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Caenorhabditis elegans)
REACT:R-DDI-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Dictyostelium discoideum)
REACT:R-MMU-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Mus musculus)
REACT:R-DRE-6799197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Danio rerio)
RHEA:30733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + FADH2 => butanoyl-CoA + FAD + H(+)
RHEA:63422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate => 2-hydroxyethylphosphonate + CTP
RHEA:10484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-feruloylglycine = (E)-ferulate + glycine
RHEA:10484	skos:prefLabel	"N-feruloylglycine deacylase"
RHEA:10484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-feruloylglycine deacylase"
REACT:R-SPO-9679775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT binds COMT Inhibitors (Schizosaccharomyces pombe)
REACT:R-RNO-141139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of TRAIL:TRAIL receptor complex (Rattus norvegicus)
GO:0060308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP cyclohydrolase I regulator activity
REACT:R-RNO-389026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galanin receptors can bind galanin (Rattus norvegicus)
REACT:R-MMU-190260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b binds to FGF (Mus musculus)
REACT:R-CFA-373741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK2 homophillic interaction (Canis familiaris)
EC:4.2.1.152	skos:altLabel	"epidermal lipoxygenase-3"
EC:4.2.1.152	skos:prefLabel	"hydroperoxy icosatetraenoate dehydratase"
EC:4.2.1.152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroperoxy icosatetraenoate dehydratase"
RHEA:25111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyridoxine <=> ADP + H(+) + pyridoxine 5'-phosphate
RHEA:57462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP => (E)-sinapyl alcohol + UDP-alpha-D-glucose
REACT:R-PFA-1369028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid efflux (Plasmodium falciparum)
REACT:R-BTA-392530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S400-Cot phosphorylates NIK (Bos taurus)
RHEA:71663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+)(out) + succinate = a menaquinol + fumarate + 2 H(+)(in)
RHEA:41519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]
RHEA:50703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-2029451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Mus musculus)
RHEA:29538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:37445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate
RHEA:24830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate
REACT:R-CFA-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Canis familiaris)
REACT:R-MMU-168166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
RHEA:66681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + coproporphyrinogen III(in) + H2O => ADP + coproporphyrinogen III(out) + H(+) + phosphate
RHEA:10595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + Li(+)(out) => H(+)(out) + Li(+)(in)
REACT:R-CEL-9610750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Caenorhabditis elegans)
RHEA:58184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + 2 phytyl diphosphate = (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)
RHEA:13578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a wax ester + H2O => a long chain fatty alcohol + a long-chain fatty acid + H(+)
RHEA:67954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Gallus gallus)
RHEA:45692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(octanoyl)-sphing-4-enine-1-phosphate(in) = N-(octanoyl)-sphing-4-enine-1-phosphate(out)
RHEA:59131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate
RHEA:44310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-MMU-3827958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by MMP9, KLK7 (Mus musculus)
RHEA:63637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty acyl-AMP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + H(+)
RHEA:64988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
RHEA:17467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnopyranose + quercetin => H2O + quercitrin
REACT:R-PFA-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)
RHEA:39790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-4615987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO2,3 (Gallus gallus)
REACT:R-SSC-159431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Sus scrofa)
REACT:R-GGA-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Gallus gallus)
REACT:R-CEL-4754176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR3-histone H3 (Caenorhabditis elegans)
REACT:R-RNO-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Rattus norvegicus)
REACT:R-CFA-9021601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Canis familiaris)
REACT:R-GGA-8869568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM1 binds TFAP2A homodimer (Gallus gallus)
REACT:R-BTA-8850786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK12 (Bos taurus)
REACT:R-BTA-8855617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Bos taurus)
REACT:R-DRE-9688831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK3 at K55, K363 (Danio rerio)
RHEA:19533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-succinylarginine dihydrolase"
RHEA:19533	skos:altLabel	"arginine succinylhydrolase"
RHEA:19533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)
RHEA:19533	skos:altLabel	"N(2)-succinylarginine dihydrolase"
RHEA:19533	skos:altLabel	"SADH"
RHEA:19533	skos:prefLabel	"N-succinylarginine dihydrolase"
REACT:R-MMU-2730886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC by SYK kinase (Mus musculus)
RHEA:38097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine => gamma-tocotrienol + S-adenosyl-L-methionine
REACT:R-SSC-975916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 5 by MGAT5 (Sus scrofa)
REACT:R-RNO-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Rattus norvegicus)
RHEA:57339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP
RHEA:15471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
RHEA:29097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+)(out) + NAD(+) + ubiquinol-8 => 5 H(+)(in) + NADH + ubiquinone-8
RHEA:39980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+-)-pavine + S-adenosyl-L-methionine => H(+) + N-methylpavine + S-adenosyl-L-homocysteine
RHEA:55590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base
GO:0033934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-maltotriohydrolase activity
GO:0033934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-D-glucan maltotriohydrolase activity
GO:0033934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltotriohydrolase activity
GO:0033934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan 1,4-alpha-maltotriohydrolase activity
REACT:R-BTA-192422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular PTL:colipase (Bos taurus)
RHEA:33343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 = 2-iminoacetate + H2O2
REACT:R-HSA-418859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Unc5C (Homo sapiens)
REACT:R-BTA-5653936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Ragulator complex (Bos taurus)
REACT:R-PFA-429798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Plasmodium falciparum)
RHEA:41786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0)
GO:0050402	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylono-1,4-lactone lactonohydrolase activity
GO:0050402	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylono-g-lactonase activity
GO:0050402	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylonolactonase activity
GO:0050402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylono-1,4-lactonase activity
GO:0016667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on a sulfur group of donors
GO:0016667	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on sulfur group of donors, other acceptors
GO:0016667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on sulphur group of donors
RHEA:70124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:40686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol <=> 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:56639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate
RHEA:69518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + N-acetyl-D-galactosamino-1,5-lactone => N-acetyl-D-galactosamine + O2
REACT:R-CEL-6809254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR8 binds MTMR9 (Caenorhabditis elegans)
RHEA:46545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:39127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH
RHEA:44357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nogalaviketone => methyl nogalonate
REACT:R-DRE-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Danio rerio)
RHEA:33643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoate + ATP + CoA = (9Z)-tetradecenoyl-CoA + AMP + diphosphate
GO:0034833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylate CoA-transferase activity
RHEA:14973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate racemase"
RHEA:14973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate = D-aspartate
RHEA:14973	skos:prefLabel	"aspartate racemase"
REACT:R-CFA-173631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1s (Canis familiaris)
REACT:R-RNO-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Rattus norvegicus)
RHEA:29045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH
RHEA:33508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine 1-phosphate => (2E)-hexadecenal + phosphoethanolamine
REACT:R-BTA-429786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Bos taurus)
REACT:R-CFA-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Canis familiaris)
REACT:R-MMU-8874080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates PTK2 (Mus musculus)
REACT:R-CFA-83677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4 deamination of cytidine (Canis familiaris)
RHEA:10486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + glycine => H2O + N-feruloylglycine
RHEA:40874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-octadecadienoyl-CoA + FADH2
RHEA:68062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:68334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate + phosphate => (R)-4'-phosphopantothenate + H2O
RHEA:33057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GTP + H(+) => guanosine 3'-diphosphate 5'-triphosphate + H2O
REACT:R-HSA-375131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Basigin binds CD98 complex (Homo sapiens)
REACT:R-HSA-5671919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CIT phosphorylates MRLCs (Homo sapiens)
REACT:R-HSA-9027627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Homo sapiens)
REACT:R-DDI-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Dictyostelium discoideum)
RHEA:30489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2S)-2-methylbutanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-isoleucine
REACT:R-GGA-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Gallus gallus)
RHEA:71537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate(out) + phosphate(in) => D-glucose 6-phosphate(in) + phosphate(out)
REACT:R-CEL-201422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Caenorhabditis elegans)
REACT:R-SSC-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Sus scrofa)
REACT:R-SSC-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Sus scrofa)
REACT:R-XTR-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Xenopus tropicalis)
REACT:R-DME-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Drosophila melanogaster)
RHEA:27549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + FADH2 + O2 <=> 3-hydroxyanthranilate + FAD + H(+) + H2O
GO:0031404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride binding
GO:0031404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride ion binding
GO:0031404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cl- ion binding
REACT:R-BTA-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)
REACT:R-GGA-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Gallus gallus)
REACT:R-SSC-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Sus scrofa)
REACT:R-SSC-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Sus scrofa)
REACT:R-SCE-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Saccharomyces cerevisiae)
REACT:R-RNO-9692738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds HRH2 antagonists (Rattus norvegicus)
GO:0033882	skos:altLabel	"choloyl-coenzyme A thioesterase"
GO:0033882	skos:prefLabel	"choloyl-CoA hydrolase"
GO:0033882	skos:altLabel	"chenodeoxycholoyl-coenzyme A thioesterase"
GO:0033882	skos:altLabel	"peroxisomal acyl-CoA thioesterase 2"
GO:0033882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chenodeoxycholoyl-coenzyme A thioesterase activity
GO:0033882	skos:altLabel	"PTE-2"
GO:0033882	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peroxisomal acyl-CoA thioesterase 2 activity
GO:0033882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choloyl-CoA hydrolase"
GO:0033882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choloyl-coenzyme A thioesterase activity
GO:0033882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTE-2
GO:0033882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA hydrolase activity
RHEA:34859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocyclopentanecarbonitrile + 2 H2O = 3-oxocyclopentanecarboxylate + NH4(+)
REACT:R-HSA-193767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Influx of 24-hydroxycholesterol (Homo sapiens)
REACT:R-XTR-706479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated (Xenopus tropicalis)
RHEA:32714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH
REACT:R-BTA-177937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of EGFR by SRC kinase (Bos taurus)
RHEA:54727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
RHEA:35281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-CoA + CoA => acetyl-CoA + hexadecanoyl-CoA
REACT:R-SSC-8942224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Filaggrin binds Keratin tonofilament:Desmosome (Sus scrofa)
REACT:R-RNO-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Rattus norvegicus)
REACT:R-HSA-1222491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoferrin scavenges iron ions (Homo sapiens)
RHEA:54606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + decanoyl-CoA + O2
RHEA:44561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-heptaprenyl diphosphate => 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate
RHEA:59738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + S-tetradecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + tetradecanoyl-CoA
REACT:R-CFA-2855125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-1 binds to molecular patterns on the target cell surface (Canis familiaris)
RHEA:48578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-cis,cis-muconate + 2 H(+) => 4-chlorocatechol + O2
REACT:R-DME-182988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty lures CBL away from EGFR (Drosophila melanogaster)
REACT:R-SSC-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Sus scrofa)
REACT:R-GGA-420883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins act as GEFs for G alpha-t (Gallus gallus)
REACT:R-HSA-382052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)
REACT:R-DDI-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Dictyostelium discoideum)
REACT:R-RNO-1604731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP3 (Rattus norvegicus)
REACT:R-DRE-2161964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Danio rerio)
REACT:R-HSA-163090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation Of The Telomeric Chromosome End (Homo sapiens)
RHEA:25293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD(+) <=> acetaldehyde + H(+) + NADH
REACT:R-MMU-163741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Mus musculus)
GO:0044877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein complex binding
GO:0044877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-containing complex binding
GO:0044877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	macromolecular complex binding
REACT:R-MMU-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)
REACT:R-HSA-5657649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALKBH2 binds alkylated DNA containing 1-etA (Homo sapiens)
REACT:R-RNO-5626549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind CALM1 (Rattus norvegicus)
RHEA:37085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine
REACT:R-MMU-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Mus musculus)
GO:0052705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylhistidine N-methyltransferase activity
GO:0052705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:N-alpha-dimethyl-L-histidine N-alpha-methyltransferase activity
GO:0052705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity
GO:0052705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylhistidine methyltransferase activity
GO:0052705	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histidine-alpha-N-methyltransferase activity
GO:0106341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	omega-hydroxyceramide transacylase activity
GO:0106341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine
REACT:R-MMU-9681763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1 binds IL1R1 inhibitors (Mus musculus)
RHEA:43838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2
GO:0050194	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoethylphosphonate phosphonohydrolase activity
GO:0050194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphonoacetaldehyde hydrolase activity
GO:0050194	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphonatase activity
GO:0050194	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphonoacetylaldehyde phosphonohydrolase activity
GO:0050194	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phosphonoacetylaldehyde phosphonohydrolase activity
REACT:R-BTA-5624126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome bind ciliary cargo (Bos taurus)
REACT:R-MMU-203625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOSTRIN mediated translocation of eNOS from plasma membrane (Mus musculus)
REACT:R-XTR-416639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Xenopus tropicalis)
REACT:R-HSA-372819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Homo sapiens)
REACT:R-SSC-8948832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 polyubiquitinates PARylated PTEN (Sus scrofa)
RHEA:15230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GTP + H(+) => diphosphate + GDP-alpha-D-mannose
REACT:R-MMU-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Mus musculus)
REACT:R-HSA-9645694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p14ARF binds C1QBP (Homo sapiens)
REACT:R-BTA-8848087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAP2 recruits STAT3 to PTK6 (Bos taurus)
REACT:R-CFA-9028730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FRS2 (Canis familiaris)
REACT:R-DME-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Drosophila melanogaster)
REACT:R-MMU-450187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated within the TAK1 complex (Mus musculus)
GO:0043843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent glucokinase activity
GO:0043843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP:D-glucose 6-phosphotransferase activity
GO:0043843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-specific glucokinase activity
REACT:R-GGA-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Gallus gallus)
REACT:R-SSC-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Sus scrofa)
REACT:R-BTA-2046175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further sulfation on galactose residues produces KSPG (Bos taurus)
RHEA:61863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroprobetaenone I + H(+) + NADPH + O2 <=> epoxybetaenone + H2O + NADP(+)
REACT:R-XTR-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Xenopus tropicalis)
REACT:R-XTR-9656891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1SW binds 11cRAL (Xenopus tropicalis)
GO:0043621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein self-association
GO:0043621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular protein binding
GO:0043621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein self binding
GO:0043621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein self association
RHEA:57730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + itaconate => H(+) + trans-aconitate
GO:0047886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity
GO:0047886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-farnesol dehydrogenase activity
GO:0047886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesol dehydrogenase activity
GO:0047886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
REACT:R-HSA-429415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to integrin alphaIIb beta3 (Homo sapiens)
REACT:R-HSA-9683760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc is transferred onto 3a (Homo sapiens)
REACT:R-HSA-190427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1b (Homo sapiens)
REACT:R-HSA-2187293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)
RHEA:48381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)
RHEA:72699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylate + H(+) + NADH = NAD(+) + propanoate
RHEA:22323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 alpha-D-glucose 1-phosphate + H2O <=> D-maltose + 2 phosphate
RHEA:27886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-AMP + H2O = 3'-AMP + H(+)
RHEA:25470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-SPO-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Schizosaccharomyces pombe)
REACT:R-XTR-5662660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopachrome is transformed to DHICA by DCT (Xenopus tropicalis)
REACT:R-GGA-1295634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is serine phosphorylated in response to MAPK activation (Gallus gallus)
REACT:R-RNO-159843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)
REACT:R-RNO-9012000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Rattus norvegicus)
REACT:R-CFA-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)
REACT:R-HSA-5244692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
REACT:R-CFA-446877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is K63 poly-ubiquitinated (Canis familiaris)
RHEA:46718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine => pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine
RHEA:60987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoate + NAD(+) <=> 16-oxohexadecanoate + H(+) + NADH
RHEA:15064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a Fe(II)-siderophore + H(+) + NAD(+) <=> 2 a Fe(III)-siderophore + NADH
RHEA:56242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein] => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]
RHEA:59785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH
REACT:R-DME-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Drosophila melanogaster)
RHEA:14451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-divinyl chlorophyllide a + H(+) + NADPH => chlorophyllide a + NADP(+)
REACT:R-MMU-2161907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Mus musculus)
RHEA:23758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydro-D-arabinono-1,4-lactone + H(+) + H2O2 => D-arabinono-1,4-lactone + O2
REACT:R-XTR-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Xenopus tropicalis)
REACT:R-RNO-909552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 at Ser727 (Rattus norvegicus)
REACT:R-SSC-549297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-XTR-9603982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeA to form LeB (Xenopus tropicalis)
RHEA:42523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2605) in 23S rRNA <=> pseudouridine(2605) in 23S rRNA
RHEA:38736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol
REACT:R-HSA-8856398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPTN binds GABA A receptors (Homo sapiens)
REACT:R-BTA-6783681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIF binds LIFR (Bos taurus)
REACT:R-DRE-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Danio rerio)
REACT:R-DME-209125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Drosophila melanogaster)
REACT:R-DRE-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Danio rerio)
RHEA:20292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O <=> acetate + CoA + H(+)
REACT:R-HSA-975852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)
RHEA:19570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine => 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Drosophila melanogaster)
RHEA:11442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+) => 2,3,5,6-tetrachlorophenol + NADPH + O2
REACT:R-MMU-6811454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate PP2A (Mus musculus)
REACT:R-CFA-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Canis familiaris)
RHEA:45330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromonapterin => 7,8-dihydroneopterin
REACT:R-RNO-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
REACT:R-HSA-3769393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ binds p-CBY:CTNNB1 (Homo sapiens)
REACT:R-DME-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Drosophila melanogaster)
REACT:R-XTR-5218812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates PAK2 (Xenopus tropicalis)
RHEA:21906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + H2O
GO:0015572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine transmembrane transporter activity
GO:0015572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-GlcNAc transmembrane transporter activity
GO:0015572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosamine permease activity
GO:0015572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylchitosamine transmembrane transporter activity
GO:0015572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine transmembrane transporter activity
GO:0015572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-Acetyl-D-glucosamine permease
REACT:R-SSC-399978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase C, alpha type phosphorylates MARCKS (Sus scrofa)
REACT:R-GGA-177922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR dimerization (Gallus gallus)
REACT:R-SSC-72143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lariat Formation and 5'-Splice Site Cleavage (Sus scrofa)
REACT:R-SSC-5690856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Sus scrofa)
RHEA:36025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:11721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 2 H2O + N-methylhydantoin => ADP + 2 H(+) + N-carbamoylsarcosine + phosphate
REACT:R-MMU-2187325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 ADP-ribosylates SMAD3 and SMAD4 (Mus musculus)
RHEA:35235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + tetracycline(in) = H(+)(in) + tetracycline(out)
REACT:R-HSA-1458463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AKT2 phosphorylates RGC2 (Homo sapiens)
REACT:R-DRE-8851538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside triphosphates (Danio rerio)
REACT:R-XTR-6800299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGFAC cleaves pro-HGF to form HGF dimer (Xenopus tropicalis)
REACT:R-DME-176585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Drosophila melanogaster)
REACT:R-CFA-433089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT can transport taurolithocholate-3-sulphate (Canis familiaris)
RHEA:41863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydecanoyl-[ACP] <=> (2E)-decenoyl-[ACP] + H2O
GO:0046914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transition metal ion binding
REACT:R-RNO-4655431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOyation of DNMT1 with SUMO1 (Rattus norvegicus)
RHEA:24930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cystine <=> NH4(+) + pyruvate + S-sulfanyl-L-cysteine
RHEA:71325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-asparagine(in) + 2 Na(+)(in) => chloride(out) + L-asparagine(out) + 2 Na(+)(out)
RHEA:68283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + pentanoyl-CoA <=> CoA + O-pentanoyl-L-seryl-[protein]
RHEA:20320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NADP(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADPH
REACT:R-CFA-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Canis familiaris)
RHEA:33677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)
REACT:R-CFA-6806610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filament formation (Canis familiaris)
RHEA:49194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-HSA-5423653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGST trimers transfer GS from GSH to AFXBO and AFNBO (Homo sapiens)
GO:0035800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deubiquitinase activator activity
REACT:R-CFA-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Canis familiaris)
REACT:R-BTA-8987040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Bos taurus)
REACT:R-XTR-5610746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI3 (Xenopus tropicalis)
RHEA:69330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate
RHEA:34425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-lariciresinol + H(+) + NADPH => (-)-secoisolariciresinol + NADP(+)
EC:1.13.11.-	skos:prefLabel	"With incorporation of two atoms of oxygen"
EC:1.13.11.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With incorporation of two atoms of oxygen"
RHEA:69017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH
RHEA:14163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoate + CO + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2
GO:0019002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP binding
RHEA:29980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine(in) + H(+)(in) => 2'-deoxyadenosine(out) + H(+)(out)
REACT:R-CFA-376122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM/DSCAML1 homodimerization (Canis familiaris)
REACT:R-SSC-201486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand pleiotrophin (PTN) (Sus scrofa)
REACT:R-DRE-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Danio rerio)
REACT:R-GGA-8987132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Gallus gallus)
REACT:R-SSC-5624949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the anterograde IFT train (Sus scrofa)
REACT:R-XTR-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Xenopus tropicalis)
RHEA:38780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:10551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + O2 <=> 4-guanidinobutanamide + CO2 + H2O
RHEA:37964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NAD(+) => D-galactose + H(+) + NADH
REACT:R-SSC-9033949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Sus scrofa)
RHEA:64575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyl diphosphate + neryl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + diphosphate
RHEA:58924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol = (-)-maackiain + H2O
REACT:R-XTR-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Xenopus tropicalis)
REACT:R-GGA-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Gallus gallus)
GO:0047758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:isobutyrate 1-phosphotransferase activity
GO:0047758	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	branched-chain-fatty-acid kinase activity
GO:0047758	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	branched-chain fatty acid kinase activity
GO:0047758	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP:branched-chain-fatty-acid 1-phosphotransferase activity
GO:0047758	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isobutyrate kinase activity
GO:0047758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:2-methylpropanoate kinase activity
GO:0047758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:2-methylpropanoate phosphotransferase activity
GO:0047758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:2-methylpropanoate 1-phosphotransferase activity
REACT:R-HSA-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)
REACT:R-CFA-448744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20RA binds IL20RB (Canis familiaris)
REACT:R-GGA-170964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 binds to active TrkA receptor (Gallus gallus)
RHEA:13247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + succinate => D-threo-isocitrate
RHEA:40681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate
RHEA:33319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-DRE-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Danio rerio)
RHEA:30187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + a quinone = a quinol + orotate
REACT:R-DDI-9676160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds NOD2 (Dictyostelium discoideum)
REACT:R-HSA-5663174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds PER1 gene (Homo sapiens)
RHEA:42646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + holo-[malonate decarboxylase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP]
REACT:R-XTR-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Xenopus tropicalis)
REACT:R-DME-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Drosophila melanogaster)
REACT:R-GGA-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Gallus gallus)
RHEA:19240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxymethyl-4-methylbut-2-en-1,4-olide <=> 4-carboxymethyl-3-methylbut-2-en-1,4-olide
REACT:R-HSA-9653180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA translocates from cytosol to mitochondrial matrix (Homo sapiens)
REACT:R-CEL-1236956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfment of particulate antigen into phagocytic vesicle (Caenorhabditis elegans)
RHEA:34903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 glutathione + 2 H(+) + selenite = glutathione disulfide + 3 H2O + selenodiglutathione
REACT:R-HSA-168915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
RHEA:59893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-amino-4-chloropent-4-enoate => chloride + H(+) + L-propargylglycine
REACT:R-HSA-399950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cofilin by LIMK-1 (Homo sapiens)
REACT:R-RNO-176631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Rattus norvegicus)
REACT:R-HSA-9035978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HEXA does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)
RHEA:27725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose <=> 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP
REACT:R-HSA-192781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral mRNA Splicing (M, NS segments) (Homo sapiens)
REACT:R-HSA-166542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-NGF dimer binds to TrkA receptor (Homo sapiens)
REACT:R-DRE-379387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DA to form 3MT (Danio rerio)
RHEA:55589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide
REACT:R-SSC-9027273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Sus scrofa)
REACT:R-HSA-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Homo sapiens)
GO:0018602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
REACT:R-RNO-2545203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cleaved cohesin (Rattus norvegicus)
RHEA:39973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobut-2-enoate => 1-aminocyclopropane-1-carboxylate
RHEA:47543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxolithocholate + H(+) + NADPH <=> NADP(+) + ursodeoxycholate
RHEA:41946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP
RHEA:10971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + CoA + GTP <=> an acyl-CoA + GDP + phosphate
GO:0008441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity
GO:0008441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'(2'),5' bisphosphate nucleotidase activity
GO:0008441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPNPase activity
GO:0008441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoadenylate 3'-nucleotidase activity
GO:0008441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylylsulfate 3'-phosphatase activity
GO:0008441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'(2'),5'-bisphosphate nucleotidase activity
GO:0008441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity
REACT:R-DRE-2396395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) binds alpha-dystroglycan (Danio rerio)
REACT:R-DDI-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Dictyostelium discoideum)
RHEA:56333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenosine + H2O => AMP + ATP + H(+)
REACT:R-CEL-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Caenorhabditis elegans)
RHEA:63068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2 H(+) + 2 malonyl-CoA = 2 CO2 + 3 CoA + triacetate lactone
REACT:R-GGA-392748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds to AP-2 Clathrin complex (Gallus gallus)
REACT:R-HSA-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Homo sapiens)
REACT:R-RNO-5579018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1(868-1441) binds PAX3(1-319) (Rattus norvegicus)
RHEA:67731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA(n) + dZTP <=> diphosphate + DNA(n)-Z
GO:0005234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellularly glutamate-gated ion channel activity
GO:0005234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular-glutamate-gated ion channel activity
REACT:R-HSA-1989772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GLIPR1 (Homo sapiens)
RHEA:25605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O = 2-(3-methylsulfanyl)propylmalate + CoA + H(+)
REACT:R-HSA-9694274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA1 is translated to pp1ab (Homo sapiens)
REACT:R-HSA-9626276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 dissociates from LAMP2a (Homo sapiens)
REACT:R-RNO-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Rattus norvegicus)
RHEA:39469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH
REACT:R-MMU-3769391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 binds the beta-catenin:CBY complex (Mus musculus)
REACT:R-XTR-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Xenopus tropicalis)
GO:0018858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate-coenzyme A ligase activity
GO:0018858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate:CoA ligase (AMP-forming)
GO:0018858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate-CoA ligase activity
GO:0018858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl CoA synthetase (AMP forming)
GO:0018858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl-coenzyme A synthetase activity
RHEA:22043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-aspartate <=> formate + L-aspartate
RHEA:38418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)
REACT:R-SSC-983427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of peptide bound class I MHC on cell surface (Sus scrofa)
RHEA:16270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) => 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH
GO:0102867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdenum cofactor sulfurtransferase activity
RHEA:68125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a fatty acyl-[ACP] => a triacylglycerol + holo-[ACP]
REACT:R-RNO-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Rattus norvegicus)
RHEA:43797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-CFA-5668731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX3 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)
REACT:R-CFA-3769383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBY1 binds beta-catenin (Canis familiaris)
GO:0102556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammarenediol 12-hydroxylase activity
RHEA:60823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH <=> adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide
RHEA:62322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isomalbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)
REACT:R-GGA-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Gallus gallus)
RHEA:67794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA => ribonucleotidyl-uridine-RNA
RHEA:30082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + crotonobetaine <=> AMP + crotonobetainyl-CoA + diphosphate
RHEA:41052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA
RHEA:20299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + aniline + H(+) => an anilide + H2O
REACT:R-CFA-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Canis familiaris)
REACT:R-SCE-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)
REACT:R-DME-5244669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Drosophila melanogaster)
REACT:R-RNO-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)
REACT:R-HSA-9683669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E protein gets N-glycosylated (Homo sapiens)
REACT:R-SSC-209973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is diiodinated (Sus scrofa)
REACT:R-DRE-2730841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV (Danio rerio)
REACT:R-DDI-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)
REACT:R-SSC-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Sus scrofa)
REACT:R-BTA-5615637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Bos taurus)
REACT:R-SPO-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Schizosaccharomyces pombe)
RHEA:52454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate
RHEA:49231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) <=> diphosphate + geranylgeranyl-bacteriochlorophyllide a
GO:0030596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-L-rhamnoside rhamnohydrolase activity
GO:0030596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosidase activity
GO:0030596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-L-rhamnosidase T
GO:0030596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-L-rhamnosidase N
GO:0008968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoheptose isomerase activity
GO:0008968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate isomerase activity
REACT:R-XTR-2161917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15S-HpETE to LXA4/B4 (Xenopus tropicalis)
REACT:R-HSA-193722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)
REACT:R-DDI-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Dictyostelium discoideum)
REACT:R-XTR-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Xenopus tropicalis)
RHEA:45220	skos:altLabel	"MT2-A"
RHEA:45220	skos:prefLabel	"[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase"
RHEA:45220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] = Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
RHEA:45220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase"
REACT:R-DME-3249390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Drosophila melanogaster)
RHEA:68596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = beta-cadinene + diphosphate
RHEA:55884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[aequorin] + 3 Ca(2+) = [aequorin]--dioxetanone
REACT:R-HSA-5218905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Homo sapiens)
RHEA:58506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-2-oxo-4-carboxy-3-hexenedioate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
REACT:R-CEL-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Caenorhabditis elegans)
RHEA:37722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-917891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Homo sapiens)
REACT:R-CEL-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Caenorhabditis elegans)
REACT:R-SSC-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Sus scrofa)
GO:0102847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity
REACT:R-CEL-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Caenorhabditis elegans)
REACT:R-RNO-192157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)
REACT:R-CFA-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Canis familiaris)
REACT:R-SCE-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)
RHEA:10606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O
REACT:R-SCE-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Saccharomyces cerevisiae)
RHEA:49508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphinomethylmalate = 2-(phosphinatomethylidene)butanedioate + H2O
RHEA:22263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triacetate lactone <=> H(+) + triacetate
RHEA:42828	skos:prefLabel	"2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase"
RHEA:42828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase"
RHEA:42828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:50260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate
RHEA:38352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH
REACT:R-XTR-9618021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXG1 binds FOXO:SMAD complexes (Xenopus tropicalis)
REACT:R-RNO-202510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1-TAB2 complex (Rattus norvegicus)
RHEA:12777	skos:prefLabel	"pteridine oxidase"
RHEA:12777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + chemical entity
RHEA:12777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pteridine oxidase"
REACT:R-MMU-8862733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR2, CCR3 bind CCL13 (Mus musculus)
RHEA:41653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin S + dTDP-2-deoxy-beta-L-fucose => 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)
REACT:R-DME-190385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3b (Drosophila melanogaster)
REACT:R-XTR-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Xenopus tropicalis)
RHEA:45512	skos:prefLabel	"phycobiliprotein beta-cysteine-155 phycobilin lyase"
RHEA:45512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]
RHEA:45512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phycobiliprotein beta-cysteine-155 phycobilin lyase"
RHEA:45512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]
REACT:R-GGA-9632412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 is recruited to methylated ESR1 (Gallus gallus)
REACT:R-GGA-421007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of Ca impermeable AMPA receptors (Gallus gallus)
REACT:R-SSC-508369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Sus scrofa)
REACT:R-DRE-4722133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Danio rerio)
REACT:R-GGA-4420128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates SHB (Gallus gallus)
EC:3.4.22.35	skos:altLabel	"histolysin"
EC:3.4.22.35	skos:prefLabel	"histolysain"
EC:3.4.22.35	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histolysain"
RHEA:12738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine => [PrdC protein]-L-selenocysteine/L-cysteine + D-proline
REACT:R-RNO-374681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 and NCAM1 engaged in cis-interaction (Rattus norvegicus)
REACT:R-HSA-2872497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-2 transports cytosolic urate to extracellular region (Homo sapiens)
REACT:R-HSA-163010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Down Regulation of Emi1 through Phosphorylation of Emi1 (Homo sapiens)
RHEA:18840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetyltaxuyunnanin C + acetyl-CoA <=> CoA + taxuyunnanin C
REACT:R-DRE-9755937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces LAN to 24,25-dhLAN (Danio rerio)
RHEA:54697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate
RHEA:43808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
RHEA:31082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisovaleryl-CoA <=> 3-methyl-(2E)-butenoyl-CoA + H2O
REACT:R-DRE-2161293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin forms aggregate globules (Danio rerio)
RHEA:31161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanoyl-CoA + NAD(+)
REACT:R-DME-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Drosophila melanogaster)
RHEA:69573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + inosine => 2'-deoxyinosine + IMP
REACT:R-CEL-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Caenorhabditis elegans)
REACT:R-SCE-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Saccharomyces cerevisiae)
RHEA:47345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]
REACT:R-CFA-422454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polysialylation of NCAM1 (Canis familiaris)
REACT:R-XTR-266051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HpETE is dehydrated to LTA4 by ALOX5 (Xenopus tropicalis)
REACT:R-CFA-9709454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR binds EPOR agonists (Canis familiaris)
REACT:R-DRE-170835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Danio rerio)
REACT:R-SSC-606287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSF complex binds the centromere (Sus scrofa)
REACT:R-DRE-5654407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates SHC1 (Danio rerio)
REACT:R-HSA-9694553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Spike trimer to assembling virion (Homo sapiens)
RHEA:72692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(out) => 17beta-estradiol 17-O-(beta-D-glucuronate)(in)
RHEA:35386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6B + S-adenosyl-L-methionine <=> CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine
REACT:R-DME-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Drosophila melanogaster)
RHEA:38779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:38042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-PFA-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)
RHEA:39111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH
GO:0071714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	icosanoid transmembrane transporter activity
GO:0071714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoid transmembrane transporter activity
RHEA:25462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sibirene => (2E,6E)-farnesyl diphosphate
REACT:R-RNO-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Rattus norvegicus)
REACT:R-MMU-1855219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Mus musculus)
REACT:R-HSA-388830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds ICOS (Homo sapiens)
REACT:R-MMU-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Mus musculus)
REACT:R-RNO-5263614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)
RHEA:51037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => 2 H2O + indole-3-pyruvate imine dimer
GO:0047133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] = formaldehyde + methylamine + reduced [electron-transfer flavoprotein]
GO:0047133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine dehydrogenase activity
GO:0047133	skos:altLabel	"DMADh"
GO:0047133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DMADh activity
GO:0047133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylamine:electron-transferring flavoprotein oxidoreductase activity
GO:0047133	skos:prefLabel	"dimethylamine dehydrogenase"
GO:0047133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylamine dehydrogenase"
REACT:R-SSC-3640858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase ADP-ribosylates AXIN (Sus scrofa)
REACT:R-BTA-8852331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 translocates to the nucleus (Bos taurus)
GO:0102482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-glucuronate isomerase activity
RHEA:39151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-CoA + NADP(+)
GO:0003690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dsDNA binding
GO:0003690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded DNA binding
RHEA:57973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-9006870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT phosphorylation (Gallus gallus)
REACT:R-SSC-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Sus scrofa)
RHEA:59846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (+)-dehydrodiconiferyl alcohol + H(+) + NADPH
REACT:R-HSA-2399977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
RHEA:40469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O
RHEA:21909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + scytalone => H(+) + NADPH + naphthalene-1,3,6,8-tetrol
RHEA:47031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfo-L-cysteine/L-cysteine <=> [DsrC protein]-disulfide + H(+) + sulfite
RHEA:27463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GDP-D-glycero-alpha-D-manno-heptose => D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+)
RHEA:44466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol
REACT:R-MMU-6807134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Mus musculus)
RHEA:38066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA <=> 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-HSA-984775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-9 is a dimer (Homo sapiens)
REACT:R-RNO-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Rattus norvegicus)
REACT:R-MMU-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Mus musculus)
RHEA:58168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-5-epieremophilene synthase"
RHEA:58168	skos:prefLabel	"(-)-5-epieremophilene synthase"
RHEA:58168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-5-epi-eremophilene + diphosphate
RHEA:19233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"palmitoyl-protein hydrolase"
RHEA:19233	skos:prefLabel	"palmitoyl-protein hydrolase"
RHEA:19233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]
RHEA:19233	skos:altLabel	"palmitoyl-protein thioesterase"
RHEA:60223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate
REACT:R-DME-4641260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL1 is degraded by the proteasome (Drosophila melanogaster)
RHEA:63914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-azauridine 5'-phosphate + ADP + H(+) => 6-azauridine + ATP
REACT:R-CFA-5661290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Canis familiaris)
REACT:R-XTR-9757951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP8 cleaves N4BP1 at D424, D490 (Xenopus tropicalis)
RHEA:51296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(R)-S-oxide-[protein]
REACT:R-HSA-9619669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-PRX dimer binds DRP2 (Homo sapiens)
REACT:R-BTA-8987033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Bos taurus)
RHEA:70044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone
REACT:R-RNO-211924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4B1 12-hydroxylates ARA (Rattus norvegicus)
REACT:R-BTA-140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)
RHEA:61127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin
RHEA:40254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-methylrhodomycin D + H2O <=> 10-carboxy-13-deoxydaunorubicin + H(+) + methanol
REACT:R-MMU-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Mus musculus)
RHEA:16789	skos:altLabel	"glycolate oxidase"
RHEA:16789	skos:altLabel	"hydroxy-acid oxidase A"
RHEA:16789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2
RHEA:16789	skos:altLabel	"hydroxy-acid oxidase B"
RHEA:16789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-2-hydroxy-acid oxidase"
RHEA:16789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + O2 = glyoxylate + H2O2
RHEA:16789	skos:prefLabel	"(S)-2-hydroxy-acid oxidase"
RHEA:48750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose + H(+) + NADH => D-threitol + NAD(+)
RHEA:26475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-L-rhamnose + phosphate => alpha-D-galactose 1-phosphate + L-rhamnopyranose
REACT:R-DDI-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Dictyostelium discoideum)
RHEA:70270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(in) + Na(+)(in) <=> hydrogencarbonate(out) + Na(+)(out)
RHEA:59700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellopentaono-1,5-lactone + H2O = D-cellopentaonate + H(+)
RHEA:11594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase] => dihydromonacolin L-[lovastatin nonaketide synthase] + H2O
GO:0018470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutaraldehyde dehydrogenase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-1-phosphate adenylyltransferase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-glucose diphosphorylase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP glucose pyrophosphorylase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPG pyrophosphorylase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose 1-phosphate adenylyltransferase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:alpha-glucose-1-phosphate adenylyl transferase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-glucose synthetase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-glucose pyrophosphorylase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphoglucose pyrophosphorylase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphate glucose pyrophosphorylase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-glucose synthase activity
GO:0008878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity
RHEA:50872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 = (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate
REACT:R-MMU-2022056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPG and CSPG translocate to the lysosome for degradation (Mus musculus)
RHEA:32619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)"
RHEA:32619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin
RHEA:32619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
RHEA:32619	skos:prefLabel	"sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)"
RHEA:61650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + salicyl-[non-ribosomal peptide synthase] => ATP + holo-[non-ribosomal peptide synthase] + salicylate
REACT:R-DDI-9020277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Dictyostelium discoideum)
RHEA:39431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-BTA-9023619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Bos taurus)
RHEA:17543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + H2O2 => an aromatic primary alcohol + O2
RHEA:31542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + S-adenosyl-L-methionine <=> (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-163402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol + H2O -> 2-acylglycerol + fatty acid (Homo sapiens)
RHEA:55417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biochanin A + UDP-alpha-D-glucose => biochanin A 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-BTA-264679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serum albumin binds 2-lysophosphatidylcholine (Bos taurus)
RHEA:39989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol
REACT:R-RNO-191784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA Cap hypermethylation (Rattus norvegicus)
GO:0050461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity
GO:0050461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity
GO:0050461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)
GO:0050461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-mimosine synthase activity
GO:0050461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity
REACT:R-CEL-8949580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F1Fo ATP synthase dimerizes (Caenorhabditis elegans)
RHEA:47512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isocholate + NAD(+)
REACT:R-BTA-8987120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IFNLR1 (Bos taurus)
REACT:R-CFA-9613570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Canis familiaris)
REACT:R-DDI-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Dictyostelium discoideum)
REACT:R-XTR-1168459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lyn activates ERK (Xenopus tropicalis)
REACT:R-DRE-9638064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Danio rerio)
RHEA:45923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-CFA-8950456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B dimerizes (Canis familiaris)
REACT:R-HSA-5683964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates EYA1-4 (Homo sapiens)
RHEA:65578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate
RHEA:10615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:60291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:67756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-418176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB2 binds MAPKs, SRC-1 (Homo sapiens)
REACT:R-RNO-2065549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Rattus norvegicus)
REACT:R-RNO-9707186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 binds ALOX5 inhibitors (Rattus norvegicus)
RHEA:26315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + L-aspartate 4-semialdehyde => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate
RHEA:44485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
RHEA:42070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clavulanate + NADP(+) => (3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH
REACT:R-SCE-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Saccharomyces cerevisiae)
RHEA:67710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O
REACT:R-XTR-6784628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Xenopus tropicalis)
REACT:R-XTR-2395324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyrrole cross-links (Xenopus tropicalis)
REACT:R-DRE-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Danio rerio)
REACT:R-CFA-1977959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with EGFR (Canis familiaris)
RHEA:32483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pheophorbidase"
RHEA:32483	skos:altLabel	"phedase"
RHEA:32483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + pheophorbide a = CO2 + methanol + pyropheophorbide a
RHEA:32483	skos:altLabel	"PPD"
RHEA:32483	skos:prefLabel	"pheophorbidase"
RHEA:24630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + 3 NADH + nitrite => 2 H2O + 3 NAD(+) + NH4(+)
RHEA:69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite => AMP + cremeomycin + diphosphate + H2O
RHEA:69664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + luteolin 7-O-beta-D-glucoside => beta-D-glucose + luteolin
REACT:R-CEL-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Caenorhabditis elegans)
REACT:R-DDI-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Dictyostelium discoideum)
REACT:R-CFA-5694431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Canis familiaris)
RHEA:48863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-HEPE + O2 <=> (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate
REACT:R-RNO-443402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Rattus norvegicus)
RHEA:59406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-homoserine => L-homoserine
REACT:R-GGA-9014449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the plasma membrane (Gallus gallus)
GO:0102923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-N-debenzoyltaxol + benzoyl-CoA = CoA + H(+) + taxol
GO:0102923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity
REACT:R-HSA-9709601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding (Homo sapiens)
RHEA:40662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate
GO:0008659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
GO:0008659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxymyristoyl-ACP dehydratase activity
GO:0008659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity
RHEA:16826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + uridine => ADP + H(+) + UMP
GO:0071172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonapterin reductase activity
RHEA:30465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-santalene + diphosphate => (2Z,6Z)-farnesyl diphosphate
REACT:R-DRE-982792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor binds JAK2 (Danio rerio)
RHEA:71642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K(+)(in) + Na(+)(in) <=> K(+)(out) + Na(+)(out)
EC:4.1.1.112	skos:prefLabel	"oxaloacetate decarboxylase"
EC:4.1.1.112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxaloacetate decarboxylase"
EC:4.1.1.112	skos:altLabel	"oxalate beta-decarboxylase"
EC:4.1.1.112	skos:altLabel	"oxaloacetate carboxy-lyase"
RHEA:56275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome cL] + H2O + methanol <=> 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)
RHEA:21009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) => diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH
REACT:R-MMU-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Mus musculus)
REACT:R-DDI-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)
REACT:R-HSA-9690404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SOX9 in testis differentiation (Homo sapiens)
REACT:R-DME-209377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polymeric PGN binds to PGRP-LCx at the plasma membrane (Drosophila melanogaster)
REACT:R-CFA-5226904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Canis familiaris)
GO:0033226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ciliatine binding
GO:0033226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoethylphosphonate binding
GO:0033226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phosphonoethylamine binding
RHEA:47911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O <=> 6-deoxy-6-sulfo-D-gluconate + H(+)
EC:6.1.1.11	skos:altLabel	"seryl-tRNA synthetase"
EC:6.1.1.11	skos:altLabel	"seryl-transfer ribonucleic acid synthetase"
EC:6.1.1.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine--tRNA ligase"
EC:6.1.1.11	skos:prefLabel	"serine--tRNA ligase"
EC:6.1.1.11	skos:altLabel	"seryl-transfer ribonucleate synthetase"
EC:6.1.1.11	skos:altLabel	"SerRS"
EC:6.1.1.11	skos:altLabel	"serine translase"
EC:6.1.1.11	skos:altLabel	"seryl-transfer RNA synthetase"
REACT:R-HSA-8987179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Homo sapiens)
REACT:R-DRE-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Danio rerio)
REACT:R-MMU-389758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)
RHEA:39186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodocosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxydocosanoyl-CoA + NADP(+)
REACT:R-BTA-5654582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates SHC1 (Bos taurus)
REACT:R-BTA-5626699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK4 binds ODF2 in the centriole (Bos taurus)
RHEA:29100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 5 H(+)(in) + NADH => a menaquinol + 4 H(+)(out) + NAD(+)
RHEA:61883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
RHEA:39096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydecanedioyl-CoA + NAD(+) => 3-oxodecanedioyl-CoA + H(+) + NADH
REACT:R-XTR-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Xenopus tropicalis)
RHEA:33966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + isopentenyl phosphate <=> ADP + isopentenyl diphosphate
RHEA:54301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate => n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)
RHEA:44475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine
RHEA:57399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine <=> 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-193743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
REACT:R-CFA-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Canis familiaris)
REACT:R-RNO-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Rattus norvegicus)
REACT:R-SSC-9633044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR binds STRN (Sus scrofa)
REACT:R-CEL-912727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds VAV (Caenorhabditis elegans)
REACT:R-RNO-2731074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Rattus norvegicus)
GO:0102616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oryzalexin A synthase activity
RHEA:71064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-histidine(out) => L-arginine(out) + L-histidine(in)
EC:5.4.2.7	skos:altLabel	"deoxyribose phosphomutase"
EC:5.4.2.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphopentomutase"
EC:5.4.2.7	skos:altLabel	"phosphodeoxyribomutase"
EC:5.4.2.7	skos:prefLabel	"phosphopentomutase"
EC:5.4.2.7	skos:altLabel	"deoxyribomutase"
REACT:R-HSA-9756162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)
REACT:R-BTA-2129375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin cross-linking by lysyl oxidase (Bos taurus)
GO:0030848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threo-3-hydroxy-L-aspartate ammonia-lyase activity
GO:0030848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)
GO:0030848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threo-3-hydroxyaspartate ammonia-lyase activity
GO:0030848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threo-3-hydroxyaspartate dehydratase activity
GO:0030848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threo-3-hydroxyaspartate dehydratase activity
GO:0030848	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-hydroxyaspartate dehydratase activity
REACT:R-SSC-158722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Sus scrofa)
RHEA:43811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-DRE-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Danio rerio)
REACT:R-CFA-5654573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds SHC1 (Canis familiaris)
RHEA:35957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B
RHEA:60793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2-oxoglutarate + gibberellin A53 + 3 O2 => 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate
REACT:R-RNO-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Rattus norvegicus)
REACT:R-DRE-6806974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET dimers autophosphorylate (Danio rerio)
RHEA:14939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-9706344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates GRB10 (Canis familiaris)
REACT:R-GGA-177943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to EGF:EGFR complex (Gallus gallus)
RHEA:17234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fucose => L-fuculose
REACT:R-CFA-9748983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)
REACT:R-MMU-1168459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lyn activates ERK (Mus musculus)
REACT:R-RNO-9020259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Rattus norvegicus)
RHEA:50881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)
REACT:R-DRE-2022056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPG and CSPG translocate to the lysosome for degradation (Danio rerio)
GO:0140226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA topoisomerase activity
REACT:R-DME-9029517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Drosophila melanogaster)
RHEA:58714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide => NADH + O2 + rifampicin
RHEA:25813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine + O2 => 3-acetamidopropanal + H2O2 + putrescine
RHEA:34451	skos:altLabel	"dTDP-4-L-rhamnose 4-epimerase"
RHEA:34451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-beta-L-talose = dTDP-beta-L-rhamnose
RHEA:34451	skos:prefLabel	"dTDP-L-rhamnose 4-epimerase"
RHEA:34451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-L-rhamnose 4-epimerase"
RHEA:58947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH <=> 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)
RHEA:37836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklavinone + H(+) + NADPH + O2 => epsilon-rhodomycinone + H2O + NADP(+)
REACT:R-SPO-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Schizosaccharomyces pombe)
REACT:R-CEL-2076383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3ST1 sulfates GlcN at C3 in heparan sulfate (Caenorhabditis elegans)
REACT:R-DRE-8858369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVRL1 binds BMP9,BMP10 (Danio rerio)
GO:0018667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanone 1,2-monooxygenase activity
GO:0018667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanone monooxygenase activity
GO:0018667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity
GO:0018667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)
GO:0018667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexanone oxygenase activity
REACT:R-CFA-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Canis familiaris)
REACT:R-XTR-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Xenopus tropicalis)
RHEA:65032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX
RHEA:60708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemal + H2O + NAD(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADH
RHEA:52050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-octadecenoyloxy)-octadecanoate + H2O
RHEA:51139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate
REACT:R-CFA-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Canis familiaris)
RHEA:37160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
REACT:R-DRE-8854905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Danio rerio)
REACT:R-RNO-1295632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA2A dephosphorylates SPRY2 (Rattus norvegicus)
REACT:R-SPO-3371467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates HSF1 (Schizosaccharomyces pombe)
RHEA:10798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole S-oxide + H2O + NADP(+) => albendazole + H(+) + NADPH + O2
RHEA:46221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,17beta-diol + NAD(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH
REACT:R-CFA-2018682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Canis familiaris)
REACT:R-XTR-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Xenopus tropicalis)
REACT:R-GGA-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Gallus gallus)
RHEA:48696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol
REACT:R-XTR-373741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK2 homophillic interaction (Xenopus tropicalis)
GO:0050098	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylguanidine hydrolase activity
GO:0050098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylguanidinase activity
GO:0050098	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylguanidine amidinohydrolase activity
REACT:R-CFA-173481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Canis familiaris)
REACT:R-HSA-1675921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane (Homo sapiens)
REACT:R-DME-432593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic JET binds to CRY, facilitating its ubiquitination (Drosophila melanogaster)
REACT:R-GGA-1234177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)
RHEA:68512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = alpha-acoradiene + diphosphate
GO:0044547	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA topoisomerase I binding
GO:0044547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA topoisomerase binding
REACT:R-SSC-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
RHEA:13630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5R)-carveol + NADP(+) => (R)-carvone + H(+) + NADPH
REACT:R-DDI-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Dictyostelium discoideum)
REACT:R-XTR-9680865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4, CYP2B6 bind ritonavir (Xenopus tropicalis)
GO:0001857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C1q receptor activity
REACT:R-DME-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Drosophila melanogaster)
REACT:R-CFA-1678920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR processing at low pH (Canis familiaris)
RHEA:25237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CDP = ADP + CTP
RHEA:54401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
RHEA:15430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine
GO:0018487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vanillate O-demethylase (anaerobic) activity
REACT:R-GGA-8933328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYPLA2 hydrolyses PALM-C3,4-GAP43 (Gallus gallus)
EC:2.8.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Sulfotransferases"
EC:2.8.2.-	skos:prefLabel	"Sulfotransferases"
RHEA:47952	skos:altLabel	"depupylase/deamidase"
RHEA:47952	skos:altLabel	"depupylase"
RHEA:47952	skos:altLabel	"DPUP"
RHEA:47952	skos:prefLabel	"Pup amidohydrolase"
RHEA:47952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Pup amidohydrolase"
RHEA:47952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O = [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)
RHEA:36953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2
RHEA:44994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-2-methylbutanoyl-(R)-carnitine => (R)-carnitine + 2-methylbutanoyl-CoA
REACT:R-CFA-1112565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Canis familiaris)
RHEA:12469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenacoside A + H2O => 26-desgluco-avenacoside A + D-glucose
REACT:R-SSC-166817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by C3 convertases (Sus scrofa)
REACT:R-GGA-433986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the  phospho-IkB (Gallus gallus)
REACT:R-SSC-5362459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Sus scrofa)
REACT:R-MMU-379044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)
REACT:R-HSA-5693558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gap-filling DNA synthesis in SDSA (Homo sapiens)
RHEA:57896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate
RHEA:33625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + dodecanoyl-CoA => ATP + CoA + dodecanoate
GO:0016692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-peroxidase activity
GO:0016692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH peroxidase activity
GO:0016692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide peroxidase activity
GO:0016692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPNH peroxidase activity
GO:0016692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphopyridine nucleotide peroxidase activity
GO:0016692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:hydrogen-peroxide oxidoreductase activity
GO:0016692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD peroxidase activity
RHEA:51777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlorisobutanophenone + dimethylallyl diphosphate => deoxycohumulone + diphosphate
RHEA:38429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O
REACT:R-DRE-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)
RHEA:64424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-leucyl-L-proline(out) = H(+)(in) + L-leucyl-L-proline(in)
REACT:R-DME-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Drosophila melanogaster)
RHEA:63380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine
RHEA:38045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-XTR-392202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 12:Gi complex (Xenopus tropicalis)
REACT:R-GGA-428518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glypican-1 (GPC1) binds SLIT2 (Gallus gallus)
REACT:R-CEL-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)
REACT:R-DME-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Drosophila melanogaster)
RHEA:30734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + FAD + H(+) <=> (2E)-butenoyl-CoA + FADH2
REACT:R-CFA-5684868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPC translocates from ER membrane to multivesicle body (Canis familiaris)
REACT:R-GGA-5654697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
GO:0047802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine conjugate aminotransferase activity
GO:0047802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-conjugate transaminase activity
GO:0047802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)
GO:0047802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity
RHEA:71831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + creatine(out) + 2 Na(+)(out) = chloride(in) + creatine(in) + 2 Na(+)(in)
RHEA:33124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate => (R)-tetraprenyl-beta-curcumene + diphosphate
RHEA:70185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose => 2 alpha-isomaltosyl-(1->4)-D-maltotriose
REACT:R-DRE-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Danio rerio)
REACT:R-HSA-77608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of A1CF to stem-looped RNA (Homo sapiens)
REACT:R-CEL-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)
REACT:R-GGA-5692779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S182 MAPKAPK5 phosphorylates FOXO1 (Gallus gallus)
REACT:R-DDI-2066778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Dictyostelium discoideum)
RHEA:49086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-5624130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylated NPHP3 translocates into the ciliary membrane (Bos taurus)
RHEA:54251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
RHEA:60301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:70043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone
RHEA:39036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-hydroxy fatty acid + NAD(+) => an omega-oxo fatty acid + H(+) + NADH
REACT:R-RNO-5577234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Rattus norvegicus)
REACT:R-RNO-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Rattus norvegicus)
RHEA:35480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'R)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + 2 H(+) + NADH
RHEA:57375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH <=> (6S)-NADPHX
RHEA:18072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine <=> D-arginine
RHEA:39077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + H2O
RHEA:15998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)
REACT:R-DRE-159843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)
REACT:R-GGA-2730900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to pUb-TRAF6 (Gallus gallus)
RHEA:70798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-lysine(out) <=> H(+)(out) + L-lysine(in)
RHEA:12549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis,4-trans-xanthoxin + NAD(+) => 2-cis-(+)-abscisic aldehyde + H(+) + NADH
RHEA:46134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2
RHEA:17295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + precorrin-3B => 2 H(+) + NADH + O2 + precorrin-3A
REACT:R-RNO-5610735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB binds ITCH (Rattus norvegicus)
REACT:R-MMU-8938913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF1 (Mus musculus)
RHEA:16310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + taurochenodeoxycholate => chenodeoxycholate + taurine
REACT:R-CFA-5662986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds copper (Canis familiaris)
RHEA:39075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenedioyl-CoA + H2O = (3S)-hydroxydodecanedioyl-CoA
REACT:R-RNO-1433514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
RHEA:55097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxypentanoyl-CoA + H2O => (3S)-3-hydroxypentanoate + CoA + H(+)
REACT:R-DDI-2294590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds phosphorylated condensin II complex (Dictyostelium discoideum)
RHEA:32928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate
REACT:R-DRE-6793661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Danio rerio)
RHEA:11992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate + O2 = H(+) + H2O2 + L-1-piperideine-6-carboxylate
RHEA:11992	skos:prefLabel	"L-pipecolate oxidase"
RHEA:11992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-pipecolate oxidase"
REACT:R-CFA-2128994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Canis familiaris)
REACT:R-SPO-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Schizosaccharomyces pombe)
RHEA:34537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-3-dehydrosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-alanine
RHEA:69190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate
REACT:R-DME-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Drosophila melanogaster)
RHEA:61114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:41337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
REACT:R-HSA-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
REACT:R-MMU-5082384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70:DNAJB1 binds HSF1 (Mus musculus)
REACT:R-HSA-9691421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK binds BTK inhibitors (Homo sapiens)
REACT:R-CEL-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Caenorhabditis elegans)
REACT:R-CEL-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Caenorhabditis elegans)
RHEA:12996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-CFA-8983841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 associates with IL6ST:IL6ST (Canis familiaris)
REACT:R-CEL-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Caenorhabditis elegans)
REACT:R-HSA-879907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate the receptor (Homo sapiens)
RHEA:54296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-tyrosyl-[protein] = diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]
RHEA:54296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanine phosphate-protein transferase"
RHEA:54296	skos:prefLabel	"guanine phosphate-protein transferase"
GO:0031768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ghrelin receptor binding
GO:0031768	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ghrelin receptor ligand
GO:0031768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 growth hormone secretagogue GH-releasing peptide receptor binding
REACT:R-SSC-5251955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Sus scrofa)
RHEA:38828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-BTA-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Bos taurus)
EC:1.14.14.151	skos:altLabel	"CYP71D55"
EC:1.14.14.151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"premnaspirodiene oxygenase"
EC:1.14.14.151	skos:prefLabel	"premnaspirodiene oxygenase"
EC:1.14.14.151	skos:altLabel	"HPO"
EC:1.14.14.151	skos:altLabel	"Hyoscymus muticus premnaspirodiene oxygenase"
RHEA:12906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GDP + H(+) => GDP-alpha-D-mannose + phosphate
REACT:R-XTR-191072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Cx43 (Xenopus tropicalis)
RHEA:64887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)
REACT:R-DME-2076220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
REACT:R-HSA-9011224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO3.1 binds DCC (Homo sapiens)
REACT:R-GGA-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Gallus gallus)
RHEA:17802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-phenylalanine => CoA + H(+) + N-acetyl-L-phenylalanine
REACT:R-MMU-202717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of CEACAMs (Mus musculus)
REACT:R-SSC-9648017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 binds to microtubules (Sus scrofa)
REACT:R-GGA-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Gallus gallus)
REACT:R-SSC-8869506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Sus scrofa)
RHEA:39267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)
REACT:R-DRE-420489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parathyroid hormone receptor can bind parathyroid hormone (Danio rerio)
REACT:R-SSC-5683385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of BRCA1-A complex at DNA DSBs (Sus scrofa)
RHEA:60429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-L-aspartate + H2O => (indol-3-yl)acetate + L-aspartate
RHEA:10018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + choline + H(+) => H2O + O-sinapoylcholine
REACT:R-RNO-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Rattus norvegicus)
RHEA:47103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + taurine <=> CoA + H(+) + taurocholate
RHEA:52438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA
REACT:R-MMU-418170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB1 binds MAPKs, SRC-1 (Mus musculus)
GO:0008476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosylprotein sulfotransferase activity
GO:0008476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity
GO:0008476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-tyrosine sulphotransferase activity
GO:0008476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-tyrosine sulfotransferase activity
RHEA:13161	skos:prefLabel	"L-threonine 3-dehydrogenase"
RHEA:13161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-threonine 3-dehydrogenase"
RHEA:13161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH
RHEA:13161	skos:altLabel	"TDH"
GO:0038085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vascular endothelial growth factor binding
GO:0038085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF binding
GO:0099619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ArnAFT activity
GO:0099619	skos:altLabel	"UDP-L-Ara4N formyltransferase"
GO:0099619	skos:altLabel	"ArnAFT"
GO:0099619	skos:prefLabel	"UDP-4-amino-4-deoxy-L-arabinose formyltransferase"
GO:0099619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-4-amino-4-deoxy-L-arabinose formyltransferase"
GO:0099619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose
GO:0099619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-L-Ara4N formyltransferase activity
GO:0099619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity
GO:0099619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase activity
GO:0031828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 2C receptor binding
GO:0031828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2C serotonin receptor binding
GO:0031828	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2C serotonin receptor ligand
REACT:R-BTA-2730884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of NTAL by p-SYK/Lyn (Bos taurus)
REACT:R-CFA-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Canis familiaris)
REACT:R-DME-372519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcCho is hydrolyzed to Cho and acetate by ACHE (Drosophila melanogaster)
REACT:R-SCE-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Saccharomyces cerevisiae)
EC:1.14.13.18	skos:prefLabel	"4-hydroxyphenylacetate 1-monooxygenase"
EC:1.14.13.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylacetate 1-monooxygenase"
EC:1.14.13.18	skos:altLabel	"4-hydroxyphenylacetic 1-hydroxylase"
EC:1.14.13.18	skos:altLabel	"4-hydroxyphenylacetate 1-hydroxylase"
EC:1.14.13.18	skos:altLabel	"4-HPA 1-hydroxylase"
REACT:R-SSC-373071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR7 binds CCL19 and 21 ligands (Sus scrofa)
RHEA:35166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + minocycline(in) <=> H(+)(in) + minocycline(out)
RHEA:63304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate
REACT:R-DRE-416698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA5A binds to PLXNB3 (Danio rerio)
RHEA:48309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O => (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)
REACT:R-DRE-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Danio rerio)
REACT:R-SPO-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)
RHEA:30899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP
RHEA:67556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + glycocholate = adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)
REACT:R-SCE-5324632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Saccharomyces cerevisiae)
REACT:R-GGA-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Gallus gallus)
RHEA:35289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + chloramphenicol(out) + H(+) + phosphate => ATP + chloramphenicol(in) + H2O
REACT:R-DME-352052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Drosophila melanogaster)
RHEA:22978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA
RHEA:20309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 = 2 H2O + O2
REACT:R-CFA-9690493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors on endosomes (Canis familiaris)
REACT:R-DRE-373724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds NCK (Danio rerio)
REACT:R-SSC-3222020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUAK1 phosphorylates TP53 (Sus scrofa)
REACT:R-XTR-2327909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN binds collagen I, II, III, VI fibrils (Xenopus tropicalis)
RHEA:56196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP
REACT:R-HSA-8865482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KMT2A (MLL) binds RUNX1 (Homo sapiens)
RHEA:60069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)
GO:0070738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin glycylase activity
GO:0070738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin-glycine ligase activity
REACT:R-RNO-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Rattus norvegicus)
RHEA:58990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enoate + H(+) + H2O2 => (E)-4-hydroxynon-2-enal + H2O + O2
REACT:R-MMU-351963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A18 transports Gly from extracellular region to cytosol (Mus musculus)
GO:0050816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphothreonine binding
GO:0050816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphothreonine residue binding
RHEA:55383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3alpha-hydroxy bile acid CoA + NAD(+) <=> a 3-oxo bile acid CoA + H(+) + NADH
REACT:R-CFA-1604360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP14 (Canis familiaris)
REACT:R-RNO-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Rattus norvegicus)
REACT:R-DRE-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Danio rerio)
RHEA:47414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA
RHEA:12263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NADH <=> ADP + H(+) + NADPH
RHEA:48402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] => 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2
RHEA:40103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propanoyl-CoA = CoA + H(+) + propanoate
REACT:R-SCE-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Saccharomyces cerevisiae)
RHEA:54928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)
RHEA:20802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine
RHEA:46975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydrobisanhydrobacterioruberin <=> AH2 + bisanhydrobacterioruberin
RHEA:49296	skos:prefLabel	"protein-N(pi)-phosphohistidine--L-sorbose phosphotransferase"
RHEA:49296	skos:altLabel	"L-sorbose PTS permease"
RHEA:49296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--L-sorbose phosphotransferase"
RHEA:49296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + L-sorbose 1-phosphate(in)
REACT:R-CFA-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Canis familiaris)
REACT:R-BTA-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Bos taurus)
RHEA:21991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside <=> 4'''-demalonylsalvianin + CoA
REACT:R-DME-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Drosophila melanogaster)
RHEA:37575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DRE-426489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC binds inexactly matching target RNAs (Danio rerio)
REACT:R-MMU-2534346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAM1 Binds Hyaluronic Acid (Mus musculus)
REACT:R-DME-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Drosophila melanogaster)
REACT:R-XTR-1475028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Xenopus tropicalis)
REACT:R-DRE-6804276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TTC5 (Danio rerio)
RHEA:46308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-5205681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is cleaved on healthy mitochondria (Bos taurus)
REACT:R-GGA-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Gallus gallus)
RHEA:70071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + sitosterol = (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-1364044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR:JAK2 dimerizes (Gallus gallus)
GO:0047153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidylate 5-hydroxymethyltransferase activity
GO:0047153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dCMP hydroxymethylase activity
GO:0047153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidylate hydroxymethylase activity
GO:0047153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyCMP hydroxymethylase activity
GO:0047153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	d-cytidine 5'-monophosphate hydroxymethylase activity
GO:0047153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidylate hydroxymethyltransferase activity
GO:0047153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity
GO:0047153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidylic hydroxymethylase activity
REACT:R-HSA-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Homo sapiens)
REACT:R-SSC-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Sus scrofa)
RHEA:68466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-butyloctan-1-ol + H(+) + sulfate => 2-butyloctyl sulfate + H2O
RHEA:59449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecan-1-ol + NADP(+) => dodecanal + H(+) + NADPH
GO:0071532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANK repeat binding
GO:0071532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ankyrin repeat binding
RHEA:68137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetophenone + H(+) + NADPH => (R)-1-phenylethanol + NADP(+)
REACT:R-DRE-190326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 (Danio rerio)
RHEA:21051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + isopropylamine + L-glutamate <=> ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate
RHEA:58360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[protein] + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate
RHEA:16698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinaldate => AH2 + kynurenate
RHEA:36784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine
RHEA:67171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-hydroxy-L-phenylalanine <=> 3-(3-hydroxyphenyl)pyruvate + L-glutamate
REACT:R-DME-9029680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-7 translocates to the nucleus (Drosophila melanogaster)
GO:0103066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity
RHEA:34490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol <=> alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)
REACT:R-MMU-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Mus musculus)
RHEA:59607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermidine <=> H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)
GO:0001716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ophio-amino-acid oxidase activity
GO:0001716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-amino-acid:oxygen oxidoreductase (deaminating)
GO:0001716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-amino-acid oxidase activity
GO:0030701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD--azoferredoxin (ADP-ribose)transferase activity
GO:0030701	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ADP-ribosyltransferase activity
GO:0030701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity
GO:0030701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-azoferredoxin (ADPribose)transferase activity
GO:0030701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity
GO:0030701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity
REACT:R-MMU-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Mus musculus)
GO:0032296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded RNA-specific ribonuclease activity
GO:0032296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dsRNA-specific RNase activity
GO:0032296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded RNA-specific RNase activity
GO:0032296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dsRNA-specific ribonuclease activity
RHEA:65663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + calciol + H2O <=> AH2 + calcidiol
REACT:R-DRE-445813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Smooth Muscle Myosin Light Chains (Danio rerio)
RHEA:53831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 <=> a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate
REACT:R-BTA-8854051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)
RHEA:19460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrophenol + 2 H(+) + 2 NADPH + O2 <=> catechol + H2O + 2 NADP(+) + nitrite
RHEA:53698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O
RHEA:40816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-RNO-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Rattus norvegicus)
RHEA:49952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10aS)-10,10a-dihydrophenazine-1-carboxylate = 5,10-dihydrophenazine 1-carboxylate
RHEA:18986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate => isochorismate
REACT:R-CFA-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Canis familiaris)
RHEA:27826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate
REACT:R-SSC-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Sus scrofa)
REACT:R-HSA-1250272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP binds NLRP3 (Homo sapiens)
REACT:R-MMU-8848005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 promotes PTK6 autophosphorylation (Mus musculus)
REACT:R-SCE-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Saccharomyces cerevisiae)
RHEA:36216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
GO:0005523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tropomyosin binding
REACT:R-HSA-189381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL translocates from the cytosol to the ER lumen (Homo sapiens)
REACT:R-DDI-9706393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds ATP (Dictyostelium discoideum)
REACT:R-RNO-1971487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHSY3 transfer GalNAc to chondroitin (Rattus norvegicus)
RHEA:34785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxosteroid + H(+) + NADPH => a 3alpha-hydroxysteroid + NADP(+)
RHEA:61810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + L-alanyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP
RHEA:41373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:53967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin <=> gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]
REACT:R-DDI-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)
RHEA:66064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxohexanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate
REACT:R-CFA-265429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Canis familiaris)
REACT:R-BTA-5671993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT-3 binds DLG4 (Bos taurus)
REACT:R-BTA-9679740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA4:ITGB1 binds natalizumab (Bos taurus)
REACT:R-HSA-5654163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds PLCG1 (Homo sapiens)
RHEA:39896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetate + UDP-alpha-D-glucose => 7-deoxyloganate + H(+) + UDP
REACT:R-DRE-1251997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ERBB4m80 by gamma-scretase complex (Danio rerio)
REACT:R-BTA-5654658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS bind to PPTN11 (Bos taurus)
REACT:R-RNO-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Rattus norvegicus)
REACT:R-BTA-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Bos taurus)
REACT:R-MMU-9020259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Mus musculus)
RHEA:19603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5-trihydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + orcinol
RHEA:36765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose
REACT:R-GGA-2730840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Gallus gallus)
RHEA:19810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + 2 H(+) + H2O => CO2 + glyoxylate + 2 NH4(+)
REACT:R-HSA-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Homo sapiens)
REACT:R-MMU-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Mus musculus)
RHEA:11459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-BTA-5689861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of XPA and release of CAK  (Bos taurus)
REACT:R-DME-3266566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Drosophila melanogaster)
RHEA:62712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone C + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin I
REACT:R-MMU-354066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PTK2 to Focal complexes (Mus musculus)
GO:0102870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxyflavone-glucosyltransferase activity
REACT:R-HSA-5336420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)
REACT:R-DRE-4084976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)
REACT:R-DRE-4655431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOyation of DNMT1 with SUMO1 (Danio rerio)
REACT:R-CFA-200421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of cytosolic AMPK by phosphorylation (Canis familiaris)
RHEA:40051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O
RHEA:40051	skos:prefLabel	"chorismate dehydratase"
RHEA:40051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chorismate dehydratase"
GO:0102495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GA5 3beta-hydroxylase activity
REACT:R-CEL-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)
GO:0016979	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lipoate-protein ligase activity (lipoylation of glycine cleavage complex)
GO:0016979	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lipoate-protein ligase B activity
GO:0016979	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lipoate-protein ligase A activity
GO:0016979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoate-protein ligase activity
GO:0008856	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Escherichia coli endodeoxyribonuclease activity
GO:0008856	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonuclease X activity
GO:0008856	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Escherichia coli endodeoxyribonuclease X activity
GO:0008856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exodeoxyribonuclease X activity
REACT:R-HSA-8878603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SSC5D binds ligands (Homo sapiens)
REACT:R-CFA-373714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-Heterodimerization of nephrin and KIRREL (Canis familiaris)
RHEA:63948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphinga-4E,14Z-dienine-1-phosphate = phosphate + sphinga-4E,14Z-dienine
RHEA:34251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxysphinganine + NADP(+) = 1-deoxy-3-dehydrosphinganine + H(+) + NADPH
REACT:R-RNO-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Rattus norvegicus)
REACT:R-DME-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Drosophila melanogaster)
REACT:R-DRE-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Danio rerio)
EC:3.1.15.1	skos:altLabel	"venom phosphodiesterase"
EC:3.1.15.1	skos:prefLabel	"venom exonuclease"
EC:3.1.15.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"venom exonuclease"
RHEA:15516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + keto-D-tagatose <=> ADP + H(+) + keto-D-tagatose 6-phosphate
REACT:R-DRE-8863718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGFG1 binds VAMP7 (Danio rerio)
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine--oxo-acid transaminase activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine-alpha-keto acid transaminase activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine-alpha-keto acid transamidase activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine:pyruvate aminotransferase activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutaminyltransferase activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine--pyruvate aminotransferase activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine transaminase L activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine-keto acid aminotransferase activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine-pyruvate transaminase activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine transaminase L
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminase II activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine-oxo acid aminotransferase activity
GO:0047945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine transaminase activity
REACT:R-HSA-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Homo sapiens)
RHEA:35226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-dADP + H2O <=> 2-oxo-dAMP + H(+) + phosphate
REACT:R-HSA-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Homo sapiens)
REACT:R-CEL-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Caenorhabditis elegans)
RHEA:33353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexacosanoylsphinganine => hexacosanoyl-CoA + sphinganine
REACT:R-CEL-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Caenorhabditis elegans)
RHEA:30914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin + H2O <=> a carboxylate + sphing-4-enine-phosphocholine
RHEA:67188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate
REACT:R-CEL-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Caenorhabditis elegans)
REACT:R-DDI-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Dictyostelium discoideum)
REACT:R-DRE-5675470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC2/3 (cIAP1/2) is autoubiquitinated (Danio rerio)
REACT:R-HSA-6804724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates phosphorylated MDM4 (Homo sapiens)
REACT:R-MMU-5661115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Mus musculus)
RHEA:51317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + glycine => H2O + N-(9Z-octadecenoyl)glycine
REACT:R-BTA-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Bos taurus)
RHEA:63698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + SN-38 O-beta-D-glucuronide + UDP => SN-38 + UDP-alpha-D-glucuronate
REACT:R-SSC-9014293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GDIs block activation of RAC2 (Sus scrofa)
REACT:R-HSA-9661625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FVIII is secreted (Homo sapiens)
REACT:R-HSA-8956649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of RUNX1 and YAP1 binds the ITCH gene promoter (Homo sapiens)
RHEA:58185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + 2 phytyl diphosphate => (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)
REACT:R-HSA-168280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Priming and Initiation of Transcription (Homo sapiens)
RHEA:71946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + 3 Na(+)(out) <=> (S)-malate(in) + 3 Na(+)(in)
GO:0062081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activating MHC class Ib receptor activity
RHEA:67897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end uridylyl-adenosine-RNA => a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine
REACT:R-MMU-451377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IQGAP1 with nephrin (Mus musculus)
GO:0070412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor regulated SMAD binding
GO:0070412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor-regulated SMAD binding
GO:0070412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pathway-restricted SMAD binding
GO:0070412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	R-SMAD binding
GO:0070412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pathway restricted SMAD binding
REACT:R-CEL-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Caenorhabditis elegans)
RHEA:67457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine
REACT:R-DDI-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Dictyostelium discoideum)
REACT:R-HSA-5684836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC1B dimer binds PDPN (Homo sapiens)
RHEA:62335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ATP <=> adenosine 3'-diphosphate,5'-diphosphate + AMP
RHEA:65782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-170964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 binds to active TrkA receptor (Bos taurus)
REACT:R-CFA-2161795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Canis familiaris)
REACT:R-DDI-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Dictyostelium discoideum)
REACT:R-MMU-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Mus musculus)
REACT:R-DRE-2197646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1 (SR-BI, CLA-1) binds ligands (Danio rerio)
RHEA:51259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 <=> (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate
RHEA:26458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylnitronate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + nitrite
RHEA:44199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylundecanoate + ATP + CoA <=> 3-methylundecanoyl-CoA + AMP + diphosphate
RHEA:46505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-AMP + holo-[ACP] => AMP + dodecanoyl-[ACP] + H(+)
RHEA:14450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + NADP(+) => 3,8-divinyl chlorophyllide a + H(+) + NADPH
RHEA:50779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanal + NADP(+) <=> (E)-hex-2-enal + H(+) + NADPH
RHEA:70003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] = cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Mus musculus)
RHEA:44332	skos:prefLabel	"L-alanine--L-anticapsin ligase"
RHEA:44332	skos:altLabel	"L-Ala-L-anticapsin ligase"
RHEA:44332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-alanine--L-anticapsin ligase"
RHEA:44332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanine + L-anticapsin = ADP + bacilysin + H(+) + phosphate
RHEA:44332	skos:altLabel	"alanine-anticapsin ligase"
RHEA:63624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-AMP + holo-[ACP] = AMP + H(+) + hexadecanoyl-[ACP]
REACT:R-HSA-9684218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M protein oligomerization (Homo sapiens)
REACT:R-BTA-114671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vWF binds to collagen (Bos taurus)
REACT:R-BTA-429567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Bos taurus)
REACT:R-SPO-8869607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NAR to yield NAMN (Schizosaccharomyces pombe)
REACT:R-GGA-9701524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated downstream of active ALK (Gallus gallus)
RHEA:45494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]
RHEA:49494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate
REACT:R-HSA-168884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemagglutinin (HA) protein synthesis (Homo sapiens)
REACT:R-HSA-9037040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC,FYN phosphorylate NTRK2 (Homo sapiens)
REACT:R-BTA-9714480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the mitochondrial membrane (Bos taurus)
RHEA:58115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1''-O-acetyl-ADP-alpha-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)
REACT:R-BTA-9686922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 binds activated RIPK1:RIPK3 (Bos taurus)
RHEA:41326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate => (5Z,8Z,11Z)-eicosatrienoate + O2
RHEA:45564	skos:prefLabel	"2-epi-5-epi-valiolone epimerase"
RHEA:45564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-epi-5-epi-valiolone epimerase"
RHEA:45564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone = 5-epi-valiolone
REACT:R-HSA-5660890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)
RHEA:42526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(1911/1915/1917) in 23S rRNA => uridine(1911/1915/1917) in 23S rRNA
RHEA:30988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => (17Z)-protosta-17(20),24-dien-3beta-ol
REACT:R-RNO-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Rattus norvegicus)
REACT:R-MMU-5691439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRISC complex deubiquitinates NLRP3 (Mus musculus)
RHEA:13422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate => an N-acylneuraminate 9-phosphate + phosphate
REACT:R-HSA-9036301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Homo sapiens)
RHEA:11443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5,6-tetrachlorophenol + NADPH + O2 <=> 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)
RHEA:15607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NH4(+) + pyruvate + sulfate => H2O + L-serine O-sulfate
REACT:R-SSC-9038029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxysterol binds ESR1, ESR2 (Sus scrofa)
RHEA:15798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin IXalpha + NAD(+) => biliverdin IXalpha + H(+) + NADH
GO:0052741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-limonene 6-monooxygenase activity
GO:0052741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity
GO:0052741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-limonene 6-monooxygenase activity
GO:0052741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-limonene-6-hydroxylase activity
REACT:R-MMU-5689085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds polyUb-PARK2 (Mus musculus)
REACT:R-HSA-9712078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK mutants bind PI3KR1 (Homo sapiens)
REACT:R-GGA-3769397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOST binds LRP5/6 (Gallus gallus)
RHEA:42424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylmaleate + H2O = (2R,3S)-3-methylmalate
REACT:R-HSA-1445143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8A,10,13,14 hydrolyze GTP (Homo sapiens)
REACT:R-RNO-8852552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1R autophosphorylates (Rattus norvegicus)
RHEA:10010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + an alcohol + H2O => [protein]-dithiol + a hydroperoxide
REACT:R-SSC-9733964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Sus scrofa)
REACT:R-SSC-5610752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R translocates to the nucleus (Sus scrofa)
REACT:R-DRE-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Danio rerio)
REACT:R-BTA-9006870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT phosphorylation (Bos taurus)
REACT:R-SPO-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Schizosaccharomyces pombe)
REACT:R-SPO-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Schizosaccharomyces pombe)
RHEA:32881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-bornane-2,5-dione + H(+) + NADH => (1R,4R,5R)-5-hydroxycamphor + NAD(+)
REACT:R-DRE-420592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectin-like (Necl) proteins (Danio rerio)
REACT:R-RNO-5621353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Rattus norvegicus)
RHEA:72641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine => 1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine
REACT:R-RNO-159443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)
REACT:R-RNO-5419281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRRF binds 55S ribosome:mRNA:tRNA (Rattus norvegicus)
REACT:R-RNO-9686922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 binds activated RIPK1:RIPK3 (Rattus norvegicus)
REACT:R-XTR-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Xenopus tropicalis)
RHEA:39464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O
GO:0001888	skos:altLabel	"glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase"
GO:0001888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase"
GO:0001888	skos:altLabel	"alpha1,4-N-acetylglucosaminyltransferase"
GO:0001888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-acetylglucosaminyltransferase I activity
GO:0001888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity
GO:0001888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
GO:0001888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0001888	skos:prefLabel	"glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase"
GO:0001888	skos:altLabel	"glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase"
GO:0001888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity
GO:0001888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,4-N-acetylglucosaminyltransferase activity
GO:0001888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha1,4-N-acetylglucosaminyltransferase activity
GO:0001888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0001888	skos:altLabel	"alpha-N-acetylglucosaminyltransferase I"
REACT:R-MMU-5661123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate Me2K5-histone H3 (Mus musculus)
REACT:R-MMU-2404131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Mus musculus)
GO:0016085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myoinhibitory hormone activity
REACT:R-DDI-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Dictyostelium discoideum)
RHEA:33786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1(F)-beta-D-fructosylsucrose + sucrose <=> 1,6-kestotetraose + beta-D-glucose
RHEA:56478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2
REACT:R-XTR-8951850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Xenopus tropicalis)
RHEA:59733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinyl-5'-AMP + L-lysyl-[protein] => AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]
GO:0016861	skos:prefLabel	"Interconverting aldoses and ketoses"
GO:0016861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Interconverting aldoses and ketoses"
GO:0016861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular isomerase activity, interconverting aldoses and ketoses
GO:0016861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
REACT:R-GGA-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Gallus gallus)
REACT:R-RNO-9708558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Rattus norvegicus)
REACT:R-RNO-8938121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds CTSK (Rattus norvegicus)
RHEA:56215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP
REACT:R-BTA-193401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
REACT:R-MMU-1471322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins are secreted (Mus musculus)
RHEA:19881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-lysyl-[protein] = diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]
REACT:R-MMU-8952058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 binds RUNX3 and displaces EP300 (Mus musculus)
REACT:R-HSA-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Homo sapiens)
REACT:R-DME-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
RHEA:69974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)
GO:0062046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydropipecolic acid reductase
RHEA:58761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)
RHEA:67961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-L-phenylalanine + S-adenosyl-L-methionine => 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-2162002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Canis familiaris)
REACT:R-RNO-8950179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B translocates from the cytosol to the extracellular region (Rattus norvegicus)
REACT:R-HSA-74207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Homo sapiens)
RHEA:59218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + skatole => (indol-3-yl)acetate + H(+)
REACT:R-SSC-6787757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates acidic AAs (Sus scrofa)
REACT:R-MMU-9011595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Mus musculus)
REACT:R-DME-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Drosophila melanogaster)
REACT:R-MMU-9008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 phosphorylates RUNX2 (Mus musculus)
EC:3.4.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Endopeptidases of unknown catalytic mechanism"
EC:3.4.99.-	skos:prefLabel	"Endopeptidases of unknown catalytic mechanism"
RHEA:20642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidinol + 2 NAD(+) => 3 H(+) + L-histidine + 2 NADH
REACT:R-DME-71825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Drosophila melanogaster)
REACT:R-XTR-9707690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 binds MAFK (Xenopus tropicalis)
REACT:R-MMU-2018682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Mus musculus)
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RanGAP
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ral GAP activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTPase activator activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rho GAP activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ran GTPase activator activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ras GAP activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rap GTPase activator activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rap GAP activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Sar GAP activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Sar GTPase activator activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rac GAP activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ARF GAP activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ARF GTPase activator activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rho GTPase activator activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rac GTPase activator activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ral GTPase activator activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ran GAP activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rab GAP activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rab GTPase activator activity
GO:0005096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ras GTPase activator activity
RHEA:39323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)
RHEA:69343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-prop-1-en-1-SO-peroxol <=> (Z)-propanethial S-oxide
RHEA:46494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in)
REACT:R-RNO-8938815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 polyubiquitinates RRAGA (Rattus norvegicus)
RHEA:40629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol
EC:1.5.1.2	skos:altLabel	"P5CR"
EC:1.5.1.2	skos:prefLabel	"pyrroline-5-carboxylate reductase"
EC:1.5.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrroline-5-carboxylate reductase"
RHEA:48161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-2161620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by PTGDS (Homo sapiens)
REACT:R-MMU-5676592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xRANK binds RANKL,sRANKL trimer:RANK (Mus musculus)
REACT:R-SSC-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)
REACT:R-RNO-264615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Rattus norvegicus)
RHEA:33986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate <=> diphosphate + miltiradiene
REACT:R-BTA-5693578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDP1 and TDP2 process unligatable DSB ends (Bos taurus)
REACT:R-CFA-1237045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Canis familiaris)
REACT:R-BTA-8983061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSLP binds CRLF2:IL7R (Bos taurus)
REACT:R-DRE-9750942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP14 deubiquitinates NLRC5 (Danio rerio)
REACT:R-DRE-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Danio rerio)
REACT:R-SSC-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Sus scrofa)
REACT:R-DRE-4719413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO2 (Danio rerio)
REACT:R-SPO-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Schizosaccharomyces pombe)
REACT:R-BTA-751001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (i) reassociates with G beta:gamma (Bos taurus)
RHEA:57213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-dGTP
REACT:R-MMU-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Mus musculus)
REACT:R-MMU-2168046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XII degradation by MMP12 (Mus musculus)
RHEA:62724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide C + FADH2
REACT:R-DRE-1483063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG and CDP-DAG are converted to CL by CRLS1 (Danio rerio)
REACT:R-XTR-392748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds to AP-2 Clathrin complex (Xenopus tropicalis)
REACT:R-HSA-8951499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides on to class I MHC (Homo sapiens)
RHEA:62971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + NADP(+) <=> H(+) + NADPH + pyruvate
RHEA:41875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydodecanoyl-[ACP] + NADP(+)
REACT:R-DME-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Drosophila melanogaster)
REACT:R-BTA-378978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Bos taurus)
EC:3.4.22.50	skos:prefLabel	"V-cath endopeptidase"
EC:3.4.22.50	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"V-cath endopeptidase"
EC:3.4.22.50	skos:altLabel	"viral cathepsin"
EC:3.4.22.50	skos:altLabel	"baculovirus cathepsin"
REACT:R-DRE-75872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Danio rerio)
RHEA:44693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + hexadecasphinganine => CoA + H(+) + N-acylhexadecasphinganine
REACT:R-CFA-8849646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK5(490-624) binds KLK5 (Canis familiaris)
REACT:R-DRE-5218815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds NCK (Danio rerio)
REACT:R-MMU-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Mus musculus)
REACT:R-XTR-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Xenopus tropicalis)
REACT:R-XTR-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Xenopus tropicalis)
REACT:R-DRE-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Danio rerio)
REACT:R-HSA-170116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin A:Cdc2 (Homo sapiens)
REACT:R-DRE-9749583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Danio rerio)
RHEA:50001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butane + H(+) + NADH + O2 => butan-1-ol + H2O + NAD(+)
REACT:R-XTR-110353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MBD4 glycosylase by APEX1 at the AP site (Xenopus tropicalis)
RHEA:11904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4-hydroxypteridine + H(+) + H2O = 2,4-dihydroxypteridine + NH4(+)
RHEA:11904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-amino-4-hydroxypteridine + H(+) + H2O = a 2,4-dihydroxypteridine + NH4(+)
RHEA:11904	skos:prefLabel	"pterin deaminase"
RHEA:11904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pterin deaminase"
REACT:R-DRE-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Danio rerio)
RHEA:64318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (+)-geodin + 2 H2O => 2 dihydrogeodin + 2 H(+) + O2
REACT:R-HSA-9028533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3, NRIP1 bind the FASN gene (Homo sapiens)
REACT:R-SSC-8949661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Sus scrofa)
REACT:R-SSC-388900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurotensin receptors can bind neurotensins (Sus scrofa)
REACT:R-GGA-398185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG binds plexin B1 (Gallus gallus)
RHEA:64367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin G2 <=> (15S)-15-hydroperoxy-prostaglandin E2
RHEA:45500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]
RHEA:59532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + S-adenosyl-L-methionine = (S)-codamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-186798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binds to PDGF-beta receptors only (Bos taurus)
REACT:R-SPO-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Schizosaccharomyces pombe)
RHEA:35099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fusidate(in) + H(+)(out) = fusidate(out) + H(+)(in)
RHEA:39468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)
REACT:R-DRE-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Danio rerio)
GO:0047583	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxaloacetate-4-methyl-ester oxaloacetohydrolase activity
GO:0047583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyloxaloacetate esterase activity
RHEA:60799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 <=> 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate
RHEA:11767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylguanidine <=> methylamine + urea
REACT:R-CFA-8853753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Canis familiaris)
REACT:R-BTA-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Bos taurus)
REACT:R-GGA-419465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O (Gallus gallus)
REACT:R-MMU-392835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 sequesters Raf1 to inhibit ERK cascade (Mus musculus)
REACT:R-HSA-8877404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the promoter of the CTLA4 gene (Homo sapiens)
RHEA:32490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-choline + H2O <=> CMP + 2 H(+) + phosphocholine
REACT:R-BTA-2065355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)
RHEA:58417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-en-1-ol + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH
RHEA:32685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dicarboxyfuran + 2 H(+) + 3 H2O2 => 5-hydroxymethylfurfural + 2 H2O + 3 O2
REACT:R-XTR-9735946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET small tyrosine kinase inhibitors bind MET (Xenopus tropicalis)
REACT:R-CEL-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Caenorhabditis elegans)
RHEA:55656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carotenoid chi-ring synthase"
RHEA:55656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + a carotenoid beta-end derivative = a carotenoid chi-end derivative + 2 AH2
RHEA:55656	skos:prefLabel	"carotenoid chi-ring synthase"
REACT:R-XTR-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Xenopus tropicalis)
REACT:R-DRE-216050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Danio rerio)
REACT:R-XTR-2090043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(7) (Xenopus tropicalis)
RHEA:51750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A
REACT:R-GGA-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Gallus gallus)
RHEA:44373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cr(6+) + 2 NADH + O2 => Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide
REACT:R-RNO-9686930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is cleaved by CASP8 (Rattus norvegicus)
RHEA:45381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate
REACT:R-HSA-5362486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Homo sapiens)
REACT:R-RNO-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Rattus norvegicus)
REACT:R-CEL-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Caenorhabditis elegans)
RHEA:72419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + ATP + H(+) = (E)-4-coumaroyl-AMP + diphosphate
REACT:R-HSA-180632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand (Homo sapiens)
RHEA:27649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + phosphate <=> alpha-D-ribose 1-phosphate + hypoxanthine
REACT:R-HSA-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Homo sapiens)
REACT:R-DRE-8938930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF2 (Danio rerio)
REACT:R-GGA-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Gallus gallus)
REACT:R-XTR-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Xenopus tropicalis)
REACT:R-HSA-4570463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
REACT:R-CFA-264871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin B1 (Canis familiaris)
REACT:R-DME-209075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)
REACT:R-RNO-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Rattus norvegicus)
REACT:R-BTA-8938930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF2 (Bos taurus)
REACT:R-GGA-190429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c (Gallus gallus)
REACT:R-DRE-9012268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)
RHEA:14689	skos:prefLabel	"4-chlorophenylacetate 3,4-dioxygenase"
RHEA:14689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-chlorophenylacetate 3,4-dioxygenase"
RHEA:14689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD(+)
RHEA:37207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-GGA-5675456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)
RHEA:42960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] = NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]
REACT:R-MMU-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)
REACT:R-CFA-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Canis familiaris)
GO:0016747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0016747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyltransferase activity, transferring groups other than amino-acyl groups
GO:0016747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transferase activity, transferring groups other than amino-acyl groups
REACT:R-DDI-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Dictyostelium discoideum)
RHEA:57445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine
REACT:R-HSA-9609747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3A (GRIN3A) (Homo sapiens)
REACT:R-RNO-5138441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A-FZD4 recruits DVL2 (Rattus norvegicus)
REACT:R-SCE-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Saccharomyces cerevisiae)
REACT:R-XTR-6786048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Xenopus tropicalis)
RHEA:12409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NAD(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)
REACT:R-HSA-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Homo sapiens)
REACT:R-DRE-6785732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases bind monoubiquitinated ID2 complex (Danio rerio)
REACT:R-DME-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)
REACT:R-SSC-450690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Sus scrofa)
REACT:R-HSA-5432849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds TLR4:LY96 (Homo sapiens)
REACT:R-MMU-8943040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF polyubiquitinates monoubiquitinated PCNA (Mus musculus)
RHEA:23011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate
RHEA:52646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-D-xylonate + H(+) => D-xylono-1,4-lactone 5-phosphate + H2O
GO:0032139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dinucleotide insertion or deletion binding
GO:0032139	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dinucleotide insertion binding
REACT:R-CFA-5687284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMBT1 binds SFTPD 12mer, SFTPAs (Canis familiaris)
RHEA:52116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate
REACT:R-HSA-5579081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ACY1 does not hydrolyse mercapturic acids (Homo sapiens)
RHEA:43842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DRE-8878787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPI dimer hydrolyses phosphate monoesters (Danio rerio)
RHEA:14285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sn-glycerol-3-phosphate 2-alpha-galactosyltransferase"
RHEA:14285	skos:altLabel	"floridoside-phosphate synthase"
RHEA:14285	skos:prefLabel	"sn-glycerol-3-phosphate 2-alpha-galactosyltransferase"
RHEA:14285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP
REACT:R-HSA-5682826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM11 (Homo sapiens)
GO:0071617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophospholipid acyltransferase activity
REACT:R-MMU-163120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)
REACT:R-SSC-9731228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)
RHEA:41496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-SSC-212263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 trimethylates histone H3 at lysine-27 (Sus scrofa)
RHEA:69271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkenimidothioate <=> an alkenyl isothiocyanate + sulfate
RHEA:45185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O
RHEA:17289	skos:altLabel	"fructose-2,6-bisphosphatase"
RHEA:17289	skos:prefLabel	"fructose-2,6-bisphosphate 2-phosphatase"
RHEA:17289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate
RHEA:17289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructose-2,6-bisphosphate 2-phosphatase"
RHEA:60826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AMP + 2 H(+) => H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate
REACT:R-CFA-388596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanocortin receptors bind melanocortins (Canis familiaris)
RHEA:63718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	losartan-1-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate
RHEA:13779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate => ATP + D-ribose 5-phosphate + NH4(+)
REACT:R-DRE-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Danio rerio)
REACT:R-DRE-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Danio rerio)
RHEA:37024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-XTR-927832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)
RHEA:36795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate
REACT:R-XTR-190261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3c binds to FGF (Xenopus tropicalis)
GO:0102205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol alpha-glucosyltransferase activity
GO:0102205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + UDP-alpha-D-glucose = cholesteryl 3-beta-D-glucoside + H(+) + UDP
GO:0102205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol allpha-glucosyltransferase activity
GO:0102205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol UDP-glucosyltransferase activity
REACT:R-XTR-8869580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEK binds TFAP2A homodimers (Xenopus tropicalis)
REACT:R-BTA-6814096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds SCOC (Bos taurus)
REACT:R-DME-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Drosophila melanogaster)
REACT:R-RNO-8878054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 (Rattus norvegicus)
REACT:R-RNO-6807008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates MET (Rattus norvegicus)
RHEA:10448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a flavanone + O2 = a flavone + CO2 + H2O + succinate
REACT:R-CFA-8957241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP73 tetramer translocates to the nucleus (Canis familiaris)
GO:0043852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MMAMT
GO:0043852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MtmB
GO:0043852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monomethylamine:corrinoid methyltransferase activity
GO:0043852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monomethylamine methyltransferase activity
REACT:R-BTA-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Bos taurus)
REACT:R-RNO-8941312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Rattus norvegicus)
REACT:R-MMU-5218851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Mus musculus)
REACT:R-SCE-6811414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF (Saccharomyces cerevisiae)
RHEA:11877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prostaglandin E2 => 15-oxoprostaglandin E2 + H(+) + NADH
RHEA:67095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + docosanoate(in) + H2O <=> ADP + docosanoate(out) + H(+) + phosphate
RHEA:58856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-oxogeraniol + H(+) + NADH
GO:0009013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate-semialdehyde:NAD(P)+ oxidoreductase activity
GO:0009013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate-semialdehyde dehydrogenase [NAD(P)+] activity
GO:0009013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))
REACT:R-XTR-176604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Xenopus tropicalis)
REACT:R-RNO-5654608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS bind to PPTN11 (Rattus norvegicus)
REACT:R-XTR-5693575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PKcs autophosphorylates (Xenopus tropicalis)
REACT:R-SSC-2509793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses dIDP to dIMP (Sus scrofa)
GO:0052603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-4-nitrosobenzene nitroreductase activity
RHEA:69624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-D-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-D-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
REACT:R-HSA-5607759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIKA2 binds K63polyUb-TRAF6 oligomer (Homo sapiens)
REACT:R-HSA-114307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SMAC (DIABLO) from mitochondria (Homo sapiens)
REACT:R-XTR-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Xenopus tropicalis)
REACT:R-XTR-8869506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Xenopus tropicalis)
REACT:R-PFA-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Plasmodium falciparum)
REACT:R-HSA-8952625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
REACT:R-HSA-2220966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)
REACT:R-BTA-8854899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Bos taurus)
RHEA:66949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate => alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA
REACT:R-RNO-139842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Syk tyrosine kinase (Rattus norvegicus)
REACT:R-SSC-9710263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GZMB cleaves GSDME (Sus scrofa)
REACT:R-SSC-1236965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Export of peptide loaded MHC class I complex to PM (Sus scrofa)
REACT:R-XTR-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Xenopus tropicalis)
REACT:R-MMU-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Mus musculus)
RHEA:55424	skos:altLabel	"DMNT/TMTT homoterpene synthase"
RHEA:55424	skos:prefLabel	"dimethylnonatriene synthase"
RHEA:55424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylnonatriene synthase"
RHEA:55424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] = (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55424	skos:altLabel	"CYP82G1"
RHEA:55424	skos:altLabel	"CYP92C5"
REACT:R-RNO-6783524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM,LIF,CTF1 receptor complex binds gp130 (Rattus norvegicus)
REACT:R-SPO-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)
REACT:R-RNO-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Rattus norvegicus)
REACT:R-GGA-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Gallus gallus)
REACT:R-DME-1604690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MMP9 intermediate form by MMPs (Drosophila melanogaster)
RHEA:41936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP
REACT:R-RNO-1028821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Phospho IRF3 or phospho IRF7 (Rattus norvegicus)
RHEA:13531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mesaconate => (3S)-citramalate
REACT:R-BTA-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Bos taurus)
REACT:R-SSC-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)
REACT:R-BTA-5638333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Bos taurus)
RHEA:12585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyprogesterone => 16,17-didehydroprogesterone + H2O
RHEA:32964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate + H2O => 2-oxoglutarate + NH4(+)
GO:0004512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1L-myo-inositol-1-phosphate lyase (isomerizing)
GO:0004512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol 1-phosphate synthetase activity
GO:0004512	skos:prefLabel	"inositol-3-phosphate synthase"
GO:0004512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate
GO:0004512	skos:altLabel	"myo-inositol-1-phosphate synthase"
GO:0004512	skos:altLabel	"D-glucose 6-phosphate cycloaldolase"
GO:0004512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-3-phosphate synthase activity
GO:0004512	skos:altLabel	"1L-myo-inositol-1-phosphate lyase (isomerizing)"
GO:0004512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose-6-phosphate inositol monophosphate cycloaldolase activity
GO:0004512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose 6-phosphate cycloaldolase activity
GO:0004512	skos:altLabel	"glucocycloaldolase"
GO:0004512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol 1-phosphate synthatase activity
GO:0004512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucocycloaldolase activity
GO:0004512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose 6-phosphate cyclase activity
GO:0004512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-3-phosphate synthase"
GO:0004512	skos:altLabel	"inositol 1-phosphate synthetase"
GO:0004512	skos:altLabel	"glucose 6-phosphate cyclase"
GO:0033924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dextran 1,6-alpha-isomaltotriosidase activity
GO:0033924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-isomaltotriohydrolase activity
GO:0033924	skos:prefLabel	"dextran 1,6-alpha-isomaltotriosidase"
GO:0033924	skos:altLabel	"exo-isomaltotriohydrolase"
GO:0033924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dextran 1,6-alpha-isomaltotriosidase"
GO:0033924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,6-alpha-D-glucan isomaltotriohydrolase activity
RHEA:57629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate => H2O + ML-236C carboxylate
REACT:R-RNO-211991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclophosphamide is 4-hydroxylated by CYP2B6 (Rattus norvegicus)
REACT:R-DDI-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Dictyostelium discoideum)
REACT:R-HSA-2671855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated LEPR Binds STAT5 (Homo sapiens)
RHEA:36568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-colitose + NAD(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH
RHEA:54576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate
REACT:R-XTR-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Xenopus tropicalis)
RHEA:72718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoate + ATP + H(+) <=> (R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate
RHEA:34968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate(in) => sn-glycerol 3-phosphate(out)
REACT:R-XTR-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Xenopus tropicalis)
REACT:R-SSC-158354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Sus scrofa)
RHEA:61307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose <=> H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP
RHEA:20909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP
RHEA:65361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
REACT:R-HSA-9606163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SYK and LYN phosphorylate BTK (Homo sapiens)
REACT:R-HSA-2161538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)
REACT:R-BTA-5684006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translocates NBN to the nucleus (Bos taurus)
REACT:R-RNO-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Rattus norvegicus)
REACT:R-DRE-5682992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A,B bind H4K20Me2 (Danio rerio)
REACT:R-SSC-2213208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type X collagen associates with collagen type II fibrils (Sus scrofa)
REACT:R-BTA-8851866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds RANBP10 (Bos taurus)
REACT:R-RNO-174657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Rattus norvegicus)
REACT:R-BTA-2130282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)
REACT:R-CFA-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Canis familiaris)
REACT:R-HSA-375330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 45/Connexin 36 mediated neuronal gap junction communication (Homo sapiens)
REACT:R-MMU-112042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid binds MOR (Mus musculus)
REACT:R-HSA-5389857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)
RHEA:22982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] => a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein]
REACT:R-MMU-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Mus musculus)
REACT:R-HSA-8939938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESRRA:PPARG1CB binds the RUNX2 gene promoter (Homo sapiens)
REACT:R-RNO-5696968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP20, USP33 deubiquitinate ADRB2 (Rattus norvegicus)
REACT:R-HSA-1236943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigen peptide onto MHC class I molecule (Homo sapiens)
RHEA:66710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O
REACT:R-XTR-453339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Xenopus tropicalis)
RHEA:27298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formylbenzoate + H2O + NAD(+) = 2 H(+) + NADH + phthalate
RHEA:27298	skos:prefLabel	"2-formylbenzoate dehydrogenase"
RHEA:27298	skos:altLabel	"2-carboxybenzaldehyde dehydrogenase"
RHEA:27298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-formylbenzoate dehydrogenase"
REACT:R-GGA-8850356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds microbial lipid-based antigen via CD1 (Gallus gallus)
RHEA:57842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1-phosphate + phosphate => 1D-myo-inositol 1,3-bisphosphate + H2O
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ferrisuperoxide dismutase activity
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SOD-1
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iron superoxide oxidoreductase
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SOD-3
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	superoxide dismutase I
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SOD
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Mn, Fe superoxide dismutase
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cuprein
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mn-SOD
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SOD-2
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	superoxide dismutase II
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	manganese superoxide dismutase activity
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	superoxide:superoxide oxidoreductase activity
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SodC reduces superoxide to H2O2 (Homo sapiens)
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SOD-4
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Cu,Zn-SOD
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Fe-SOD
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Cu-Zn superoxide dismutase activity
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytocuprein
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hepatocuprein
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nickel superoxide dismutase activity
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	manganese superoxide oxidoreductase
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hemocuprein
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	copper, zinc superoxide dismutase activity
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SODS
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SODF
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nickel superoxide oxidoreductase
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythrocuprein
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	iron superoxide dismutase activity
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc superoxide oxidoreductase
GO:0004784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	superoxide dismutase activity
RHEA:37389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-XTR-110354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of OGG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)
REACT:R-DDI-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)
REACT:R-GGA-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Gallus gallus)
RHEA:11624	skos:altLabel	"pyruvate-acetone oximinotransferase"
RHEA:11624	skos:altLabel	"transoximinase"
RHEA:11624	skos:prefLabel	"oximinotransferase"
RHEA:11624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate
RHEA:11624	skos:altLabel	"oximase"
RHEA:11624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oximinotransferase"
REACT:R-DME-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Drosophila melanogaster)
REACT:R-DRE-159771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein C to protein C (Danio rerio)
RHEA:43289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate
REACT:R-RNO-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)
REACT:R-SSC-8987033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Sus scrofa)
RHEA:10932	skos:altLabel	"citrulline--aspartate ligase"
RHEA:10932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"argininosuccinate synthase"
RHEA:10932	skos:altLabel	"argininosuccinate synthetase"
RHEA:10932	skos:altLabel	"arginine succinate synthetase"
RHEA:10932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
RHEA:10932	skos:prefLabel	"argininosuccinate synthase"
RHEA:20151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + quinine + reduced [NADPH--hemoprotein reductase]
GO:0052849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH-dependent curcumin reductase activity
REACT:R-GGA-5692770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Gallus gallus)
RHEA:40228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + desulfo-A47934 => A47934 + adenosine 3',5'-bisphosphate + H(+)
REACT:R-RNO-6805755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)
REACT:R-GGA-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Gallus gallus)
GO:0102446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnetin 3-O-methyltransferase activity
REACT:R-XTR-209792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylation of serotonin (Xenopus tropicalis)
RHEA:38113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-glyceraldehyde + NADPH => glycerol + NADP(+)
RHEA:40585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + hexanedioate => H2O + hexanedioyl-CoA
RHEA:46692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + H(+) = 4-hydroxybenzoyl-5'-AMP + diphosphate
REACT:R-SSC-5684273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Sus scrofa)
GO:0062057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate:fumarate antiporter activity
REACT:R-HSA-1791116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DDX11 (Homo sapiens)
RHEA:41161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O
GO:0015043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:ferrileghemoglobin oxidoreductase activity
GO:0015043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferric leghemoglobin reductase activity
GO:0015043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leghemoglobin reductase activity
REACT:R-BTA-9677579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Bos taurus)
REACT:R-HSA-6794355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 binds mGluR1a,5 (Homo sapiens)
REACT:R-CEL-70859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Caenorhabditis elegans)
RHEA:54263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparaginyl-[protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate
RHEA:36937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:55378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a quinone + 2 H2O => 2 a quinol + O2
RHEA:30414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + benzyl alcohol <=> benzyl benzoate + CoA
RHEA:27546	skos:altLabel	"anthranilate hydroxylase"
RHEA:27546	skos:prefLabel	"anthranilate 3-monooxygenase (FAD)"
RHEA:27546	skos:altLabel	"anthranilate 3-hydroxylase"
RHEA:27546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthranilate 3-monooxygenase (FAD)"
RHEA:27546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H(+) + H2O
RHEA:46328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-3-phenylserine = 3-phenylpyruvate + NH4(+)
REACT:R-DRE-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Danio rerio)
REACT:R-SSC-9653503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B is phosphorylated on serine 181 (Sus scrofa)
RHEA:45037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Fe(III)-[cytochrome c] + hydroxylamine => 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide
REACT:R-DME-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
RHEA:20617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate
RHEA:20617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-galactonolactone oxidase"
RHEA:20617	skos:prefLabel	"L-galactonolactone oxidase"
RHEA:20617	skos:altLabel	"L-xylono-1,4-lactone oxidase"
REACT:R-RNO-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Rattus norvegicus)
RHEA:22819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xylose <=> alpha-D-xylulofuranose
REACT:R-RNO-1564120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII degradation by MMP1,2,3 (Rattus norvegicus)
RHEA:61627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + cadaverine <=> 5-aminopentanal + L-glutamate
REACT:R-XTR-8854466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds RELN (Xenopus tropicalis)
RHEA:14676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a polar amino acid(out) + ATP + H2O <=> a polar amino acid(in) + ADP + H(+) + phosphate
REACT:R-DRE-6805792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S291-PHF20 translocates to cytosol (Danio rerio)
REACT:R-SSC-176609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + PAPS => cholesterol sulfate + PAP (Sus scrofa)
REACT:R-SSC-8937989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRC1 complexes (Sus scrofa)
RHEA:50801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin A2 => prostaglandin A2-S-(S)-glutathione
RHEA:67659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + NADPH <=> 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)
RHEA:51973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9033491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Mus musculus)
REACT:R-SSC-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Sus scrofa)
RHEA:31189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanoyl-CoA + H(+) + NADH => (3S)-hydroxydecanoyl-CoA + NAD(+)
REACT:R-DRE-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Danio rerio)
REACT:R-SSC-2396594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Sus scrofa)
REACT:R-DRE-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Danio rerio)
RHEA:37110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(7)-methyl-GMP <=> N(7)-methylguanosine + phosphate
RHEA:61488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-373071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR7 binds CCL19 and 21 ligands (Canis familiaris)
GO:0052690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) = 2,3,6-trichlorohydroquinone + 2 glutathione
GO:0052690	skos:prefLabel	"tetrachlorohydroquinone reductive dehalogenase"
GO:0052690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trichloro-p-hydroquinone reductive dehalogenase activity
GO:0052690	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	xenobiotic reductase activity
GO:0052690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6-trichlorohydroquinone + chloride + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione
GO:0052690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrachlorohydroquinone reductive dehalogenase"
GO:0052690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pentaerythritol tetranitrate reductase activity
GO:0052690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trichlorohydroquinone reductive dehalogenase activity
GO:0052690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrachlorohydroquinone reductive dehalogenase activity
RHEA:53788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholoyl-CoA + beta-muricholate = allodeoxycholate + beta-muricholoyl-CoA
RHEA:23890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine
REACT:R-CFA-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Canis familiaris)
REACT:R-BTA-390304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoASH (Bos taurus)
RHEA:56451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-BTA-5159245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Bos taurus)
REACT:R-GGA-1638821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
REACT:R-BTA-8853774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Bos taurus)
REACT:R-MMU-177926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of PAG by SHP2 (Mus musculus)
RHEA:12889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH
RHEA:12889	skos:prefLabel	"L-gulonate 3-dehydrogenase"
RHEA:12889	skos:altLabel	"L-3-aldonate dehydrogenase"
RHEA:12889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-gulonate 3-dehydrogenase"
REACT:R-DDI-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Dictyostelium discoideum)
REACT:R-CEL-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Caenorhabditis elegans)
RHEA:19892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-glucose
RHEA:41744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)
REACT:R-GGA-5654157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR2 (Gallus gallus)
RHEA:71432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)
REACT:R-CFA-434362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment Of Cytoplasmic Proteins To Vesicles (Canis familiaris)
GO:0032138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single base insertion or deletion binding
GO:0032138	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	single base insertion binding
REACT:R-BTA-3361751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin is replaced by repression complexes at the promoter (Bos taurus)
REACT:R-MMU-9020271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Mus musculus)
RHEA:42255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + pentanoyl-CoA <=> 3-oxoheptanoyl-[ACP] + CO2 + CoA
RHEA:33451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] = AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]
RHEA:59631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(4-aminobutanoyl)-L-arginine <=> 4-aminobutanoate + L-arginine
RHEA:27841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-carbazole + H(+) + NADH + O2 <=> 2'-aminobiphenyl-2,3-diol + NAD(+)
RHEA:51688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NAD(+) = H(+) + keto-L-tagatose + NADH
RHEA:51688	skos:prefLabel	"galactitol 2-dehydrogenase (L-tagatose-forming)"
RHEA:51688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactitol 2-dehydrogenase (L-tagatose-forming)"
REACT:R-DRE-2213243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of COPII vesicle with Golgi complex (Danio rerio)
REACT:R-HSA-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Homo sapiens)
REACT:R-DDI-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)
RHEA:16301	skos:altLabel	"NADase"
RHEA:16301	skos:altLabel	"NAD nucleosidase"
RHEA:16301	skos:altLabel	"beta-NAD(+) glycohydrolase"
RHEA:16301	skos:prefLabel	"NAD(+) glycohydrolase"
RHEA:16301	skos:altLabel	"diphosphopyridine nucleosidase"
RHEA:16301	skos:prefLabel	"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase"
RHEA:16301	skos:altLabel	"DPN hydrolase"
RHEA:16301	skos:altLabel	"nicotinamide adenine dinucleotide nucleosidase"
RHEA:16301	skos:altLabel	"DPNase"
RHEA:16301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase"
RHEA:16301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide
RHEA:16301	skos:altLabel	"NAD(+) nucleosidase"
RHEA:16301	skos:altLabel	"nicotinamide adenine dinucleotide glycohydrolase"
RHEA:16301	skos:altLabel	"NAD hydrolase"
RHEA:16301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(+) glycohydrolase"
RHEA:16301	skos:altLabel	"NAD glycohydrolase"
RHEA:16301	skos:altLabel	"ADP-ribosyl cyclase"
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branching glycosyltransferase activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-glucan branching enzyme activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen branching enzyme activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosan transglycosylase activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glucan-branching glycosyltransferase activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enzyme Q
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amylo-(1,4 to 1,6)transglucosidase activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amylo-(1,4->1,6)-transglycosylase activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amylose isomerase activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branching enzyme activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	plant branching enzyme
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enzymatic branching factor
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-glucan-6-(1,4-glucano)-transferase activity
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	starch branching enzyme
GO:0003844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Q-enzyme
REACT:R-DME-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Drosophila melanogaster)
REACT:R-SCE-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Saccharomyces cerevisiae)
RHEA:35137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-L-glutamate(in) => L-alanyl-L-glutamate(out)
RHEA:52662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + an L-alpha-aminoacyl-[ACP] + diphosphate => an L-alpha-amino acid + ATP + holo-[ACP]
REACT:R-MMU-445064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by VAV2 (Mus musculus)
REACT:R-MMU-6788855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3KRP phosphorylates PsiAm, RibAm (Mus musculus)
REACT:R-GGA-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Gallus gallus)
RHEA:57285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA
REACT:R-DRE-377640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of SRC (Danio rerio)
RHEA:53220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Mus musculus)
REACT:R-BTA-398193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC beta-mediated PIP2 hydrolysis (Bos taurus)
REACT:R-XTR-173754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Properdin stabilizes C3b:Bb bound to cell surfaces (Xenopus tropicalis)
REACT:R-MMU-9606894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DAPP1 (p-BAM32) binds PLCG2 (Mus musculus)
RHEA:66408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O = ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate
REACT:R-RNO-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Rattus norvegicus)
REACT:R-MMU-419011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectins (Mus musculus)
RHEA:27997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + xanthosine <=> D-ribose + xanthine
REACT:R-CFA-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Canis familiaris)
REACT:R-HSA-139919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BIM to mitochondria (Homo sapiens)
REACT:R-SCE-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Saccharomyces cerevisiae)
REACT:R-DDI-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Dictyostelium discoideum)
REACT:R-RNO-4088264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Rattus norvegicus)
REACT:R-HSA-2465921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cRDH oxidises 11cROL to 11cRAL (Homo sapiens)
RHEA:24458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ribazole + phosphate => alpha-ribazole 5'-phosphate + H2O
REACT:R-MMU-2395340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxyallysine by LOX (Mus musculus)
RHEA:15739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-valerolactone + H2O + NADP(+) => cyclopentanone + H(+) + NADPH + O2
RHEA:63560	skos:altLabel	"angiotensin I-converting enzyme"
RHEA:63560	skos:altLabel	"ACE"
RHEA:63560	skos:prefLabel	"peptidyl-dipeptidase A"
RHEA:63560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine
RHEA:63560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidyl-dipeptidase A"
RHEA:63560	skos:altLabel	"carboxycathepsin"
RHEA:63560	skos:altLabel	"peptidyl dipeptidase I"
RHEA:63560	skos:altLabel	"dipeptidyl carboxypeptidase I"
RHEA:63560	skos:altLabel	"peptidase P"
RHEA:63560	skos:altLabel	"kininase II"
GO:0140832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-histidine(out) + Na(+)(out) = H(+)(out) + L-histidine(in) + Na(+)(in)
GO:0140832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine, sodium:proton antiporter activity
RHEA:56842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+) => 5-amino-2-hydroxybenzoate + O2
REACT:R-DME-8854071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome-mediated degradation of PolyUb-FBXL7 (Drosophila melanogaster)
RHEA:59193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + eicosanoate + H(+) => diphosphate + icosanoyl-AMP
RHEA:15359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethyllactenocin + dTDP + H(+) => 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose
REACT:R-GGA-3928645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB:NMDAR binds TIAM1 (Gallus gallus)
RHEA:16330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
REACT:R-DRE-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Danio rerio)
REACT:R-SSC-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Sus scrofa)
REACT:R-RNO-2530445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD59 inhibits MAC formation (Rattus norvegicus)
REACT:R-BTA-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Bos taurus)
REACT:R-SSC-8985914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Sus scrofa)
REACT:R-CEL-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Caenorhabditis elegans)
REACT:R-SPO-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Schizosaccharomyces pombe)
RHEA:40935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)
RHEA:25436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate
RHEA:25436	skos:prefLabel	"alpha-bisabolene synthase"
RHEA:25436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-bisabolene synthase"
REACT:R-XTR-1497869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - Sepiapterin is reduced to BH2 (Xenopus tropicalis)
RHEA:72843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA(in) + ADP(out) = 3'-dephospho-CoA(out) + ADP(in)
REACT:R-HSA-5665751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP:FMNL2 binds Profilin:G-actin (Homo sapiens)
REACT:R-SSC-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Sus scrofa)
REACT:R-CEL-5693925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers L-fucose to Gal1,3GlcNAc (Caenorhabditis elegans)
GO:0036203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxoid 14-beta-hydroxylase activity
RHEA:63146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoate + ethanolamine => H2O + N-(15Z-tetracosenoyl)-ethanolamine
REACT:R-CFA-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Canis familiaris)
REACT:R-CFA-5654514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds FGFR1c (Canis familiaris)
REACT:R-DME-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Drosophila melanogaster)
REACT:R-MMU-2022063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Mus musculus)
RHEA:44182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-SSC-140599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Sus scrofa)
REACT:R-HSA-5663050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHI and DHICA polymerise forming eumelanin (Homo sapiens)
RHEA:51411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-RNO-8987039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL20RA (Rattus norvegicus)
RHEA:24038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-phosphate + ATP
RHEA:13484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-methionine + tRNA(Met) <=> AMP + diphosphate + L-methionyl-tRNA(Met)
REACT:R-MMU-6786012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Mus musculus)
REACT:R-HSA-6782628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates STAM2:HGS (Homo sapiens)
RHEA:41663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + NAD(+) <=> NADH + sanguinarine
RHEA:25620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terpentedienyl diphosphate <=> diphosphate + terpentetriene
REACT:R-RNO-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Rattus norvegicus)
REACT:R-XTR-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Xenopus tropicalis)
RHEA:38687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine(in) + ATP + H2O = (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate
GO:0003777	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	kinetochore motor activity
GO:0003777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	kinesin
GO:0003777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dynein
GO:0003777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule motor activity
GO:0003777	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	kinesin motor activity
GO:0003777	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dynein ATPase activity
GO:0003777	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	axonemal motor activity
GO:0003777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent microtubule motor activity
REACT:R-RNO-373741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK2 homophillic interaction (Rattus norvegicus)
RHEA:45496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]
REACT:R-CFA-9707353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 binds Aromatase inhibitors (Canis familiaris)
RHEA:12661	skos:prefLabel	"carnitine O-palmitoyltransferase"
RHEA:12661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnitine O-palmitoyltransferase"
RHEA:12661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)-carnitine
RHEA:47293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23928	skos:altLabel	"N(8)-monoacetylspermidine deacetylase"
RHEA:23928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylspermidine deacetylase"
RHEA:23928	skos:altLabel	"N(1)-acetylspermidine amidohydrolase"
RHEA:23928	skos:altLabel	"N(8)-acetylspermidine amidohydrolase"
RHEA:23928	skos:altLabel	"N(8)-acetylspermidine deacetylase"
RHEA:23928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(8)-acetylspermidine = acetate + spermidine
RHEA:23928	skos:prefLabel	"acetylspermidine deacetylase"
RHEA:23928	skos:altLabel	"N-acetylspermidine deacetylase"
GO:0047568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity
GO:0047568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-5beta-steroid 4-dehydrogenase activity
GO:0047568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity
GO:0047568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta4-3-ketosteroid 5-beta-reductase activity
GO:0047568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5-beta-steroid 4-dehydrogenase activity
RHEA:32442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-8944232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XII (Danio rerio)
REACT:R-GGA-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)
RHEA:68329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + H2O => (R)-pantetheine + phosphate
REACT:R-DRE-8852522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 dimer:MST1R dimer binds MST1R dimer (Danio rerio)
REACT:R-HSA-5218855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCAR1 binds p-7Y-PTK2 (Homo sapiens)
REACT:R-DRE-216756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)
RHEA:41594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH
REACT:R-HSA-373086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR10 binds CCL27 and 28 ligands (Homo sapiens)
REACT:R-BTA-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Bos taurus)
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BB-CK
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphocreatine kinase activity
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	creatine phosphokinase activity
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine kinase activity
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MiMi-CK
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mi-CK
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MM-CK
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CK-MB
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MB-CK
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CK
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine triphosphate-creatine transphosphorylase activity
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CK-MM
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CK-BB
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:creatine N-phosphotransferase activity
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:creatine phosphotransferase activity
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	creatine phosphotransferase activity
GO:0004111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CKMiMi
REACT:R-HSA-168140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Homo sapiens)
REACT:R-MMU-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Mus musculus)
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin C acylase activity
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CA
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin acylase activity
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaryl-7-aminocephalosporanic acid acylase activity
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GA
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-7-aminocephalosporanic-acid acylase activity
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GL-7-ACA acylase activity
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GCA
GO:0033968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaryl-7-ACA acylase activity
REACT:R-MMU-372819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Mus musculus)
REACT:R-SPO-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Schizosaccharomyces pombe)
RHEA:49085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] => (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triglucosyl-enterobactin = [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)
REACT:R-HSA-4719354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective DPM3 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)
RHEA:42955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(49) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:22963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-2022919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Danio rerio)
REACT:R-DME-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Drosophila melanogaster)
REACT:R-HSA-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Homo sapiens)
REACT:R-BTA-9750016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Bos taurus)
REACT:R-RNO-426489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC binds inexactly matching target RNAs (Rattus norvegicus)
REACT:R-DME-164840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP and Pi bind to ATPase (Drosophila melanogaster)
REACT:R-GGA-936947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Gallus gallus)
REACT:R-GGA-8944240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type III (Gallus gallus)
REACT:R-SSC-5654422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS2 (Sus scrofa)
GO:0030246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	selectin
GO:0030246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sugar binding
GO:0030246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate binding
RHEA:57092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + S-(methylsulfanyl)glutathione = A + glutathione + methanethiol
RHEA:18471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-acyl-L-glutamine + CoA + H(+) => an acyl-CoA + L-glutamine
RHEA:21818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H2O2 + NH4(+) => a D-alpha-amino acid + H2O + O2
REACT:R-CFA-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Canis familiaris)
REACT:R-HSA-996755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFPM proteins bind GATA proteins (Homo sapiens)
REACT:R-HSA-9632906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)
REACT:R-BTA-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)
RHEA:46402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-BTA-419981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Bos taurus)
REACT:R-XTR-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Xenopus tropicalis)
REACT:R-BTA-9698408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates active FLT3 (Bos taurus)
REACT:R-SSC-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Sus scrofa)
REACT:R-HSA-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Homo sapiens)
REACT:R-DME-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Drosophila melanogaster)
REACT:R-HSA-391868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)
RHEA:42745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:24411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H(+) + H2O <=> inosine + NH4(+)
REACT:R-CFA-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Canis familiaris)
REACT:R-RNO-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Rattus norvegicus)
RHEA:20335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase] => ATP + L-seryl-[acetyl-CoA carboxylase]
RHEA:28391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-psicosyl)-L-lysine => N(6)-(D-fructosyl)-L-lysine
RHEA:22333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalate => 2-methylmaleate + H2O
REACT:R-MMU-9793679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates RIPK1 at K627 (Mus musculus)
REACT:R-MMU-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Mus musculus)
RHEA:47520	skos:prefLabel	"3beta-hydroxycholanate 3-dehydrogenase (NADP(+))"
RHEA:47520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isolithocholate + NADP(+)
RHEA:47520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3beta-hydroxycholanate 3-dehydrogenase (NADP(+))"
RHEA:47520	skos:altLabel	"3beta-hydroxysteroid dehydrogenase"
REACT:R-MMU-446701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4-activated IRAK1 autophosphorylates (Mus musculus)
RHEA:16424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:51095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-threonyl-[L-threonyl-carrier protein] 4-chlorinase"
RHEA:56812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 = 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate
RHEA:56812	skos:prefLabel	"L-threonyl-[L-threonyl-carrier protein] 4-chlorinase"
RHEA:56720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]
REACT:R-HSA-2161659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGE2 is dehydrated to PGA2 (Homo sapiens)
REACT:R-RNO-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Rattus norvegicus)
GO:0047819	skos:prefLabel	"D-glutamate(D-aspartate) oxidase"
GO:0047819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamic-aspartic oxidase activity
GO:0047819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)
GO:0047819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glutamate(D-aspartate) oxidase"
GO:0047819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate(D-aspartate) oxidase activity
GO:0047819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-monoaminodicarboxylic acid oxidase activity
RHEA:14342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + glyoxylate + H(+) => 2-hydroxy-3-oxoadipate + CO2
REACT:R-RNO-5625738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Rattus norvegicus)
REACT:R-RNO-6804383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 methylates TP53 (Rattus norvegicus)
RHEA:35370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH <=> isoheptadecanoyl-coA + NADP(+)
REACT:R-MMU-2267372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Mus musculus)
REACT:R-DRE-177931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Danio rerio)
REACT:R-SPO-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Schizosaccharomyces pombe)
REACT:R-XTR-73931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Xenopus tropicalis)
REACT:R-XTR-1454781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Xenopus tropicalis)
REACT:R-HSA-1839110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BCR-p-FGFR1 phosphorylates GAB2 (Homo sapiens)
REACT:R-CFA-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Canis familiaris)
REACT:R-XTR-6803875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds CDK1 and CCNB1 (Xenopus tropicalis)
RHEA:63557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynorphin A-(1-13) + H2O => dynorphin A-(1-12) + L-lysine
RHEA:41669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + NADP(+) => chelirubine + NADPH
REACT:R-MMU-2471621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin degradation by cathepsins (Mus musculus)
RHEA:46643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)
RHEA:68614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F1 => H(+) + NADPH + prostaglandin E1
REACT:R-HSA-3788725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)
REACT:R-MMU-173626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1r (Mus musculus)
RHEA:72604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + ATP + H(+) => (E)-sinapoyl-AMP + diphosphate
RHEA:49764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylenediaminetriacetate + FMNH2 + O2 = ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O
RHEA:54603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + octanoyl-CoA <=> 2-hydroxyoctanoyl-CoA + CO2 + succinate
REACT:R-MMU-5656070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFBPs bind FGFs (Mus musculus)
REACT:R-RNO-3000137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Rattus norvegicus)
REACT:R-CEL-6801776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A binds bacterial phospholipids (Caenorhabditis elegans)
RHEA:35856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
GO:0140416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription regulator inhibitor activity
GO:0140416	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA-binding transcription factor inhibitor activity
REACT:R-SCE-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Saccharomyces cerevisiae)
RHEA:67767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-CFA-5662606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds zinc (Canis familiaris)
REACT:R-SSC-205231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of KIT upon SCF binding (Sus scrofa)
REACT:R-HSA-1504186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)
REACT:R-XTR-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Xenopus tropicalis)
RHEA:53373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(17) in tRNA + NAD(+) => H(+) + NADH + uridine(17) in tRNA
REACT:R-BTA-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Bos taurus)
RHEA:42295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + phosphate <=> an acyl phosphate + holo-[ACP]
REACT:R-HSA-9754537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 3a tetramer binds to VPS39 within HOPS complex (Homo sapiens)
RHEA:32979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-L-serine
RHEA:36951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 = (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:44254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:72081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(in) + selenate(in) => 3 Na(+)(out) + selenate(out)
REACT:R-BTA-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Bos taurus)
RHEA:21973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-1 + S-adenosyl-L-methionine => precorrin-2 + S-adenosyl-L-homocysteine
RHEA:24913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L,L-cystathionine <=> 2-aminobut-2-enoate + L-cysteine
RHEA:24110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + methylamine => H2O + N-methyl-2-oxoglutaramate
REACT:R-XTR-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Xenopus tropicalis)
REACT:R-HSA-975902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)
REACT:R-CFA-1470010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs (Canis familiaris)
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
GO:0047253	skos:altLabel	"uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI"
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity
GO:0047253	skos:altLabel	"N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI"
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase"
GO:0047253	skos:altLabel	"N-acetylglucosaminyltransferase VI"
GO:0047253	skos:altLabel	"GlcNAc-T VI"
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminyltransferase VI activity
GO:0047253	skos:altLabel	"mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase"
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0047253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity
GO:0047253	skos:prefLabel	"alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase"
GO:0047253	skos:altLabel	"GnTVI"
REACT:R-HSA-9694344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)
REACT:R-CFA-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Canis familiaris)
REACT:R-SSC-5676607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF,sAPRIL binds TACI,BCMA (Sus scrofa)
GO:0016408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-acyltransferase activity
RHEA:64456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine
RHEA:64456	skos:prefLabel	"[histone H4]-lysine(20) N-trimethyltransferase"
RHEA:64456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H4]-lysine(20) N-trimethyltransferase"
REACT:R-BTA-176474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Bos taurus)
RHEA:68174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + isodomoate A + succinate => 2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2
RHEA:21790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2
REACT:R-DRE-2730833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TEC kinases by p-SYK (Danio rerio)
RHEA:29092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + 5 H(+)(in) + NADH => a ubiquinol + 4 H(+)(out) + NAD(+)
REACT:R-RNO-6788611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYKK phosphorylates 5HLYS (Rattus norvegicus)
REACT:R-MMU-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Mus musculus)
REACT:R-MMU-8852167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:Catecholamine binds ARRB1, ARRB2 (Mus musculus)
RHEA:70511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
REACT:R-RNO-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)
RHEA:38916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)
REACT:R-MMU-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Mus musculus)
RHEA:20321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NAD(+) = 1-pyrroline-2-carboxylate + H(+) + NADH
RHEA:20002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolaldehyde + H2O + NAD(+) => glycolate + 2 H(+) + NADH
REACT:R-DRE-9686980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 recruits APC/C:Cdh1 complex to SKP2 (Danio rerio)
REACT:R-DRE-5674366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)
REACT:R-RNO-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Rattus norvegicus)
REACT:R-MMU-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Mus musculus)
GO:0102275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-S-conjugate N-malonyl transferase activity
REACT:R-SSC-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Sus scrofa)
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent glyceraldehyde phosphate dehydrogenase activity
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglyceraldehyde dehydrogenase activity
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceraldehyde phosphate dehydrogenase (NAD)
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoglyceraldehyde dehydrogenase activity
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	triosephosphate dehydrogenase activity
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceraldehyde-3-P-dehydrogenase activity
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-glyceraldehyde phosphate dehydrogenase activity
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GAPDH activity
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0004365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, glyceraldehyde phosphate
REACT:R-GGA-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)
RHEA:70855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + L-serine(in) + Na(+)(out) = L-glutamine(in) + L-serine(out) + Na(+)(in)
REACT:R-HSA-5623525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo-carrying vesicles bud from the TGN (Homo sapiens)
REACT:R-RNO-1793182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Rattus norvegicus)
REACT:R-HSA-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)
REACT:R-HSA-9613648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOX10 dimer binds the POU3F1 promoter (Homo sapiens)
REACT:R-DRE-5423664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)
REACT:R-GGA-975903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Gallus gallus)
REACT:R-RNO-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Rattus norvegicus)
RHEA:71194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid(in) + L-kynurenine(out) <=> an L-alpha-amino acid(out) + L-kynurenine(in)
RHEA:30919	skos:altLabel	"carotenoid 3,4-dehydrogenase"
RHEA:30919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-hydroxycarotenoid 3,4-desaturase"
RHEA:30919	skos:altLabel	"hydroxyneurosporene desaturase"
RHEA:30919	skos:altLabel	"1-hydroxycarotenoid 3,4-dehydrogenase"
RHEA:30919	skos:prefLabel	"1-hydroxycarotenoid 3,4-desaturase"
RHEA:30919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + rhodopin = (3E)-3,4-didehydrorhodopin + AH2
RHEA:38562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate <=> (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:34106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:31337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + Mo-molybdopterin cytosine dinucleotide => CTP + H(+) + Mo-molybdopterin
GO:0010488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity
REACT:R-HSA-2396337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)
GO:0042736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH kinase activity
GO:0042736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:NADH 2'-phosphotransferase activity
GO:0042736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide adenine dinucleotide kinase (phosphorylating)
GO:0042736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPNH kinase activity
GO:0042736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced diphosphopyridine nucleotide kinase activity
REACT:R-SSC-6809663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hair keratin fibres (Sus scrofa)
REACT:R-XTR-201423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI complexes with the Smad complex, suppressing BMP2 signalling (Xenopus tropicalis)
RHEA:44779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-6 + S-adenosyl-L-methionine <=> H(+) + menaquinol-6 + S-adenosyl-L-homocysteine
REACT:R-CFA-6787677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUOM isomerises alpha-Fuc to beta-Fuc (Canis familiaris)
REACT:R-HSA-9026008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA (Homo sapiens)
REACT:R-GGA-5624949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the anterograde IFT train (Gallus gallus)
REACT:R-BTA-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Bos taurus)
GO:0017174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:glycine methyltransferase activity
GO:0017174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine N-methyltransferase activity
GO:0017174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine methyltransferase activity
GO:0017174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GNMT
GO:0017174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:glycine N-methyltransferase activity
RHEA:55357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol => 13-cis-retinol
REACT:R-CFA-6804425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F2 (Canis familiaris)
REACT:R-MMU-9707690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 binds MAFK (Mus musculus)
REACT:R-RNO-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Rattus norvegicus)
RHEA:43207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-265426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Tenascin (Sus scrofa)
RHEA:61280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + H2O + O2 = H2O2 + NH4(+) + succinate semialdehyde
REACT:R-CFA-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Canis familiaris)
REACT:R-RNO-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
RHEA:71212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorate(out) + 2 Na(+)(out) => chlorate(in) + 2 Na(+)(in)
GO:0016917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid binding
GO:0016917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA receptor activity
GO:0016917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyrate binding
GO:0016917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate receptor activity
GO:0016917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid receptor activity
GO:0016917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyrate receptor activity
GO:0016917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA binding
REACT:R-RNO-194023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2,HSD11B1 dimer oxidise CORT to COR (Rattus norvegicus)
REACT:R-HSA-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Homo sapiens)
REACT:R-HSA-6788571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)
REACT:R-HSA-9700137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK:MDK dimerization (Homo sapiens)
RHEA:54256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidyl-[protein] + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate
REACT:R-MMU-5654409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS2 (Mus musculus)
REACT:R-BTA-9657619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Bos taurus)
REACT:R-SSC-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Sus scrofa)
REACT:R-DRE-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Danio rerio)
REACT:R-DME-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Drosophila melanogaster)
RHEA:48249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) => CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)
REACT:R-SSC-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Sus scrofa)
REACT:R-RNO-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Rattus norvegicus)
RHEA:26102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-homocitrate => cis-homoaconitate + H2O
RHEA:29571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-idonate(in) = H(+)(out) + L-idonate(out)
RHEA:39880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol
REACT:R-GGA-433864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 binds to the IRAK4 accociated  with the complex of the activated TLR : TIRAP : MyD88 (Gallus gallus)
RHEA:17285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monoglucosyldiacylglycerol synthase"
RHEA:17285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP
RHEA:17285	skos:prefLabel	"monoglucosyldiacylglycerol synthase"
REACT:R-XTR-159566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Xenopus tropicalis)
REACT:R-DME-216222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COS binds to SMO (Drosophila melanogaster)
RHEA:33434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxyhexa-2,4-dienedioate <=> (3E)-2-oxohex-3-enedioate
REACT:R-DME-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Drosophila melanogaster)
RHEA:58077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(11Z-eicosenoyl)-glycerol + H2O => (11Z)-eicosenoate + glycerol + H(+)
REACT:R-BTA-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Bos taurus)
REACT:R-DRE-5685318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex formation (Danio rerio)
REACT:R-DME-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Drosophila melanogaster)
REACT:R-MMU-9674529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds to TBXA2R (Mus musculus)
REACT:R-CFA-5676591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Canis familiaris)
REACT:R-XTR-9014641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Xenopus tropicalis)
RHEA:23456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + AH2 + O2 = A + crepenynate + 2 H2O
REACT:R-CFA-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Canis familiaris)
RHEA:20022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + deoxyamidinoproclavaminate + O2 => amidinoproclavaminate + CO2 + succinate
REACT:R-GGA-437139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT6 transports zinc into the golgi apparatus (Gallus gallus)
REACT:R-XTR-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-BTA-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Bos taurus)
REACT:R-SCE-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Saccharomyces cerevisiae)
REACT:R-DME-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Drosophila melanogaster)
REACT:R-GGA-1168643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCP ubiquitinylates IkB (Gallus gallus)
REACT:R-CEL-8871260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD2 (Caenorhabditis elegans)
RHEA:46072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + H(+) + NADH = hexadecanoyl-CoA + NAD(+)
REACT:R-HSA-8939054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the PRKCB gene promoter (Homo sapiens)
REACT:R-DRE-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Danio rerio)
RHEA:47127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hexacosanoate <=> H2O + N-hexacosanoylglycine
REACT:R-RNO-5433067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Rattus norvegicus)
REACT:R-CFA-373073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR1, 2 and 8 bind CCL16 ligand (Canis familiaris)
REACT:R-MMU-193060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates ANDST to E1 (Mus musculus)
REACT:R-SCE-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Saccharomyces cerevisiae)
RHEA:70410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 <=> (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine
REACT:R-BTA-8951966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates RUNX3 (Bos taurus)
REACT:R-MMU-1855162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Mus musculus)
REACT:R-RNO-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Rattus norvegicus)
REACT:R-MMU-83803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Mus musculus)
REACT:R-MMU-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
REACT:R-RNO-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)
REACT:R-BTA-205118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 polyubiquitinates NRIF (Bos taurus)
RHEA:17770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-GGA-6785898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R binds JAK2 (Gallus gallus)
REACT:R-GGA-4551724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 (Gallus gallus)
RHEA:56751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9656207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 RAF1 mutants don't bind YWHAB (Homo sapiens)
REACT:R-RNO-2581474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK1,4,7 phosphorylate MII to p-MII (Rattus norvegicus)
RHEA:24122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-leukotriene E4 + H2O + NADP(+) => H(+) + leukotriene E4 + NADPH + O2
RHEA:64476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate
REACT:R-HSA-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Homo sapiens)
REACT:R-CFA-997309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
GO:0042562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hormone binding
RHEA:44068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)
RHEA:65279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpent-2-enoyl-CoA + H2O => (R)-2-hydroxy-4-methylpentanoyl-CoA
RHEA:14813	skos:altLabel	"alpha-amino-epsilon-caprolactam racemase"
RHEA:14813	skos:prefLabel	"2-aminohexano-6-lactam racemase"
RHEA:14813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-aminohexano-6-lactam racemase"
RHEA:14813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam
RHEA:14813	skos:altLabel	"2-amino-hexano-6-lactam racemase"
REACT:R-SSC-5336184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37L binds prosaposin (Sus scrofa)
REACT:R-DRE-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)
REACT:R-DRE-8858298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRASLS transfer acyl group from PC to PE to form NAPE (Danio rerio)
GO:0047015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity
GO:0047015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity
GO:0047015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
GO:0047015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity
GO:0047015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity
RHEA:61676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP = AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]
REACT:R-HSA-8870558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5:p25 phosphorylates FOXO3 (Homo sapiens)
GO:0140911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pore forming activity
GO:0140911	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	canonical holin activity
GO:0140911	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	holin activity
GO:0140911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pore-forming activity
GO:0140911	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pinholin activity
REACT:R-BTA-442368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
REACT:R-MMU-391933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP3 receptor can bind PGE2 (Mus musculus)
RHEA:56443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:63616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin + UDP-alpha-D-glucuronate = H(+) + prunetin-C(8)-beta-D-glucuronide + UDP
REACT:R-HSA-432096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
REACT:R-GGA-373813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR2 binds ligands CXCL1 to 7 (Gallus gallus)
RHEA:46597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + rifampicin => 2'-N-hydroxyrifampicin + H2O + NADP(+)
RHEA:59051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ornithine + H(+) <=> CO2 + putrescine
RHEA:59462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanal + NADPH => hexadecan-1-ol + NADP(+)
REACT:R-DME-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Drosophila melanogaster)
RHEA:27597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 5 diphosphate
RHEA:29113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + ubiquinol-8 => H(+) + NADPH + ubiquinone-8
REACT:R-DME-110491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRheb is inhibited by the TSC1/2 complex (Drosophila melanogaster)
REACT:R-DRE-2562594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated OPTN translocates to the nucleus (Danio rerio)
REACT:R-RNO-8866308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL translocates from RER membrane to SER lumen (Rattus norvegicus)
REACT:R-HSA-6804441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF34 or RFFL ubiquitinates phosphorylated TP53 (Homo sapiens)
REACT:R-MMU-419389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA-binding receptors bind LPA (Mus musculus)
REACT:R-HSA-5638012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D dissociates from ARL13B:INPP5E (Homo sapiens)
REACT:R-HSA-114684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Syntaxin-4 (Homo sapiens)
REACT:R-SSC-5676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD74 binds MIF (Sus scrofa)
REACT:R-XTR-444731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Xenopus tropicalis)
REACT:R-CFA-5250947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH complex binds rDNA promoter (Canis familiaris)
RHEA:44990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-isobutanoyl-(R)-carnitine => (R)-carnitine + 2-methylpropanoyl-CoA
RHEA:69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 => 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)
RHEA:29330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + succinate(out) <=> (S)-malate(out) + succinate(in)
RHEA:24767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
GO:0047236	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity
GO:0047236	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity
GO:0047236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-ONN-azoxymethanol glucosyltransferase activity
GO:0047236	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cycasin synthase activity
GO:0047236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity
GO:0047236	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-methylazoxymethanol glucosyltransferase activity
RHEA:36978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + phosphate <=> adenine + alpha-D-ribose 1,5-bisphosphate
REACT:R-DRE-374331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bradykinin receptors B1 and B2 bind to bradykinin (Danio rerio)
EC:3.4.14.2	skos:altLabel	"dipeptidyl aminopeptidase II"
EC:3.4.14.2	skos:altLabel	"dipeptidyl arylamidase II"
EC:3.4.14.2	skos:prefLabel	"dipeptidyl-peptidase II"
EC:3.4.14.2	skos:altLabel	"quiescent cell proline dipeptidase"
EC:3.4.14.2	skos:altLabel	"carboxytripeptidase"
EC:3.4.14.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dipeptidyl-peptidase II"
EC:3.4.14.2	skos:altLabel	"DPP II"
REACT:R-DRE-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Danio rerio)
RHEA:25925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-8-ol => 8-hydroxyquinolin-2(1H)-one + AH2
REACT:R-HSA-9656209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RHEA:33517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 indole-5,6-quinone => 2 5,6-dihydroxyindole + O2
RHEA:57507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate
REACT:R-SSC-420598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:Nectin-4 trans heterodimer formation (Sus scrofa)
REACT:R-DME-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)
RHEA:59153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + pseudomonate C => AMP + diphosphate + pseudomonoyl-CoA C
REACT:R-CFA-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Canis familiaris)
REACT:R-SSC-194311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Sus scrofa)
REACT:R-DRE-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Danio rerio)
RHEA:17930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + ATP => ADP + an N-acylsphing-4-enine 1-phosphate + H(+)
REACT:R-RNO-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Rattus norvegicus)
REACT:R-SSC-1604722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP9 by proteases (Sus scrofa)
RHEA:11809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bergaptol + S-adenosyl-L-methionine => bergapten + S-adenosyl-L-homocysteine
REACT:R-HSA-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
RHEA:42857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate
RHEA:10067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine
RHEA:40674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminopropanoate + H2O <=> NH4(+) + pyruvate
RHEA:35362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisoheptadecanoyl-CoA <=> (2E)-15-methylhexadecenoyl-CoA + H2O
GO:0043730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-ureido-4-imidazole carboxylate hydrolase activity
RHEA:48284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = globoside NOR1 (d18:1(4E)) + H(+) + UDP
RHEA:45225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA
REACT:R-BTA-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Bos taurus)
REACT:R-CEL-9619355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the cytosol (Caenorhabditis elegans)
REACT:R-DME-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)
REACT:R-RNO-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Rattus norvegicus)
REACT:R-MMU-380949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK is dephosphorylated (Mus musculus)
REACT:R-RNO-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Rattus norvegicus)
REACT:R-HSA-873918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of JAK1 (Homo sapiens)
RHEA:16911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+) => 2 Fe(III)-[cytochrome c] + glycine + H2O
RHEA:19773	skos:prefLabel	"glycerol-3-phosphate 1-dehydrogenase (NADP(+))"
RHEA:19773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sn-glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + H(+) + NADPH
RHEA:19773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-3-phosphate 1-dehydrogenase (NADP(+))"
RHEA:19773	skos:altLabel	"glycerin-3-phosphate dehydrogenase"
RHEA:12554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-pinosylvin + 4 CO2 + 4 CoA => (E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA
REACT:R-BTA-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Bos taurus)
REACT:R-SCE-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Saccharomyces cerevisiae)
REACT:R-PFA-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Plasmodium falciparum)
RHEA:10224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate
RHEA:39521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH
GO:0140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding cassette transporter
GO:0140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC transporter
GO:0140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type transmembrane transporter activity
GO:0140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-binding cassette transporter
GO:0140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type uptake permease activity
GO:0140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type efflux porter activity
GO:0140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type efflux permease activity
GO:0140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-binding cassette (ABC) transporter activity
GO:0140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type transporter activity
REACT:R-HSA-2213201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibres (Homo sapiens)
RHEA:49165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine
GO:0008511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:potassium:chloride symporter activity
GO:0008511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/potassium/chloride symporter activity
REACT:R-DME-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Drosophila melanogaster)
REACT:R-DRE-5654600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
RHEA:71952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + sulfate(out) => 3 Na(+)(in) + sulfate(in)
REACT:R-GGA-2132187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBL or ficolin binds an oligosaccharide pattern on the target cell surface (Gallus gallus)
RHEA:27933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4-phosphopantoate + ATP + beta-alanine <=> (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)
RHEA:36293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + NADP(+) + xanthine => 3-methylxanthine + H(+) + NADPH + O2
RHEA:36699	skos:prefLabel	"8-demethylnovobiocic acid synthase"
RHEA:36699	skos:altLabel	"novobiocin ligase"
RHEA:36699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP = 8-desmethylnovobiocic acid + AMP + diphosphate
RHEA:36699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-demethylnovobiocic acid synthase"
RHEA:36699	skos:altLabel	"8-demethylnovobiocic acid synthetase"
RHEA:72399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + estrone 3-sulfate(in) = 2-oxoglutarate(in) + estrone 3-sulfate(out)
REACT:R-SSC-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Sus scrofa)
REACT:R-XTR-5685156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2 (Xenopus tropicalis)
REACT:R-HSA-111915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK4 autophosphorylates (Homo sapiens)
RHEA:52920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:63310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:22815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) <=> 5,10-methenyltetrahydrofolate + NADPH
RHEA:56953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + pyruvate => CDP + H(+) + phosphoenolpyruvate
REACT:R-HSA-2974731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 (Homo sapiens)
GO:0102432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 7-O-methyltransferase activity
REACT:R-HSA-416698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA5A binds to PLXNB3 (Homo sapiens)
REACT:R-RNO-5694442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH2,3 bind GRIA1 (Rattus norvegicus)
REACT:R-XTR-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Xenopus tropicalis)
RHEA:14270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a quinone + H(+) + NADPH => 2 a 1,4-benzosemiquinone + NADP(+)
RHEA:15178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine
REACT:R-DRE-8956140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 and UBD bind NUB1 and the 26S proteasome (Danio rerio)
REACT:R-SSC-444606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R2/T1R3 dimer is a sweet taste receptor (Sus scrofa)
REACT:R-XTR-4088134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates FOXM1 (Xenopus tropicalis)
RHEA:37894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin T + H2O <=> 15-demethylaclacinomycin T + methanol
REACT:R-MMU-4754187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Mus musculus)
REACT:R-CFA-8964274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12) binds BTK (Canis familiaris)
RHEA:34864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2,3-didehydroadipyl-CoA + H2O => 3-hydroxyadipyl-CoA
RHEA:35533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albonoursin + 2 H2O2 => cyclo(L-phenylalanyl-L-leucyl) + 2 O2
REACT:R-SCE-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Saccharomyces cerevisiae)
REACT:R-RNO-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Rattus norvegicus)
RHEA:58840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-374663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Ezrin (Homo sapiens)
REACT:R-CFA-1793207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses C4S/C6S chains (Canis familiaris)
REACT:R-SSC-3371385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α is cleaved by ADAM17 (TACE) (Sus scrofa)
RHEA:55399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + H(+) + NADH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine
RHEA:31747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH
RHEA:31747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase"
RHEA:31747	skos:prefLabel	"3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase"
RHEA:43756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[ribosomal protein S18]-alanine N-acetyltransferase"
RHEA:43756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]
RHEA:43756	skos:prefLabel	"[ribosomal protein S18]-alanine N-acetyltransferase"
REACT:R-DDI-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)
REACT:R-BTA-9709831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds TBK1 and IRF3 (Bos taurus)
REACT:R-HSA-190682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin synthesis (generic) (Homo sapiens)
REACT:R-DME-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Drosophila melanogaster)
RHEA:69084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + H2O + NAD(+) = acrylate + 2 H(+) + NADH
REACT:R-DRE-8944246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXI (Danio rerio)
REACT:R-GGA-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)
REACT:R-BTA-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Bos taurus)
REACT:R-DRE-5654607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PPTN11 (Danio rerio)
RHEA:53586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2
REACT:R-DRE-1964496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds TRIM32 or TRIM56  (Danio rerio)
RHEA:18511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + NAD(+) => H(+) + H2O2 + NADH
RHEA:68568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(5)-hydroxy-L-ornithine = (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O
RHEA:23430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate
RHEA:68860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxo-25-hydroxycholesterol + H(+) + NADPH = 7beta-25-dihydroxycholesterol + NADP(+)
REACT:R-MMU-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Mus musculus)
REACT:R-HSA-5618073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)
REACT:R-DRE-3341397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)
RHEA:11215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole + O2 <=> 2-formamidobenzaldehyde
RHEA:36247	skos:prefLabel	"trans-anol O-methyltransferase"
RHEA:36247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-anol = H(+) + S-adenosyl-L-homocysteine + trans-anethole
RHEA:36247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-anol O-methyltransferase"
RHEA:36247	skos:altLabel	"T-anol O-methyltransferase"
RHEA:55478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine => an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:32769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine
RHEA:38712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol
RHEA:47759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
GO:0033568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactoferrin receptor activity
REACT:R-XTR-3247493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO1 (Xenopus tropicalis)
REACT:R-RNO-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)
REACT:R-RNO-209921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoiodinated tyrosine can be deiodinated (Rattus norvegicus)
REACT:R-DRE-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Danio rerio)
REACT:R-SSC-8941543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Sus scrofa)
REACT:R-DME-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Drosophila melanogaster)
RHEA:18307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + N-acetyl-4-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate
RHEA:68555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine <=> H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
REACT:R-RNO-391157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds SKAP2 (Rattus norvegicus)
REACT:R-GGA-5634103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 dissociates from atRA:RAR:RXR (Gallus gallus)
RHEA:55595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (3R)-hydroxydecanoyl-[ACP] + H2O <=> (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]
REACT:R-MMU-8875568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 activates RAP1 (Mus musculus)
REACT:R-GGA-352994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoglycerate <=> 2-phosphoglycerate (Gallus gallus)
REACT:R-CFA-5635855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Canis familiaris)
RHEA:56710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:59368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)
RHEA:21507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin + aldehydo-D-ribose 5-phosphate <=> 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde
RHEA:37227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-sorbate + H(+) = (E)-1,3-pentadiene + CO2
REACT:R-RNO-5693549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Rattus norvegicus)
REACT:R-MMU-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Mus musculus)
RHEA:58423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prenol <=> 3-methyl-2-butenal + H(+) + NADPH
GO:0001006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0001006	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase III type 3 promoter DNA binding
GO:0030108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLA-A specific activating MHC class I receptor activity
REACT:R-HSA-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Homo sapiens)
GO:0033784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	senecionine monooxygenase (N-oxide-forming) activity
GO:0033784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SNO
GO:0033784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + senecionine = H2O + NADP(+) + senecionine N-oxide
GO:0033784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"senecionine N-oxygenase"
GO:0033784	skos:altLabel	"senecionine monooxygenase (N-oxide-forming)"
GO:0033784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	senecionine N-oxygenase activity
GO:0033784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity
GO:0033784	skos:prefLabel	"senecionine N-oxygenase"
REACT:R-CEL-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Caenorhabditis elegans)
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10-methylenetetrahydromethanopterin + H(+)
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H(2)-dependent methylene-H(4)MPT dehydrogenase activity
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N5,N10-methenyltetrahydromethanopterin hydrogenase activity
GO:0047068	skos:altLabel	"N(5),N(10)-methenyltetrahydromethanopterin hydrogenase"
GO:0047068	skos:prefLabel	"5,10-methenyltetrahydromethanopterin hydrogenase"
GO:0047068	skos:altLabel	"hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase"
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N5,N10-methylenetetrahydromethanopterin dehydrogenase activity
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H2-dependent methylene-H4MPT dehydrogenase activity
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity
GO:0047068	skos:altLabel	"nonmetal hydrogenase"
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methenyltetrahydromethanopterin hydrogenase activity
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nonmetal hydrogenase activity
GO:0047068	skos:altLabel	"H2-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase"
GO:0047068	skos:altLabel	"H2-dependent methylene-H4MPT dehydrogenase"
GO:0047068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5,10-methenyltetrahydromethanopterin hydrogenase"
REACT:R-CFA-9025999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Canis familiaris)
REACT:R-HSA-6802919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RHEA:52839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole + NADH + O2 <=> H2O + indoxyl + NAD(+)
RHEA:57587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:61661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + ATP => (2E)-geranyl phosphate + ADP + H(+)
REACT:R-BTA-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Bos taurus)
REACT:R-SPO-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)
REACT:R-DRE-1236954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides by IRAP in endocytic vesicles (Danio rerio)
GO:0047922	skos:altLabel	"gentisate oxygenase"
GO:0047922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gentisate oxygenase activity
GO:0047922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H(+)
GO:0047922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gentisic acid oxidase activity
GO:0047922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gentisate 1,2-dioxygenase"
GO:0047922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gentisate:oxygen 1,2-oxidoreductase (decyclizing)
GO:0047922	skos:prefLabel	"gentisate 1,2-dioxygenase"
GO:0047922	skos:altLabel	"gentisic acid oxidase"
GO:0047922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gentisate 1,2-dioxygenase activity
GO:0047922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gentisate dioxygenase activity
GO:0047922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-dihydroxybenzoate dioxygenase activity
RHEA:25257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate
REACT:R-MMU-77312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Mus musculus)
REACT:R-DME-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)
RHEA:17109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)
REACT:R-SSC-9014449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the plasma membrane (Sus scrofa)
REACT:R-DDI-8938770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Dictyostelium discoideum)
REACT:R-HSA-183094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds CBL:Beta-Pix (Homo sapiens)
REACT:R-MMU-165182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of complexed TSC2 by PKB (Mus musculus)
REACT:R-CFA-204798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and p85 of PI3K (Canis familiaris)
REACT:R-XTR-176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST trimers transfer GS from GSH to luminal substrates (Xenopus tropicalis)
REACT:R-SCE-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Saccharomyces cerevisiae)
REACT:R-BTA-3232162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates MITF with SUMO1 (Bos taurus)
REACT:R-GGA-349603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Gallus gallus)
REACT:R-XTR-2395869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
REACT:R-MMU-8871194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 and GAPVD1 bind AP-2 (Mus musculus)
REACT:R-HSA-5654643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
RHEA:27992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + ADP + H(+) => 1-deoxy-D-xylulose + ATP
RHEA:54573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in tRNA => a pseudouridine in tRNA
RHEA:64596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)
RHEA:64596	skos:prefLabel	"inositol phosphorylceramide mannosyltransferase"
RHEA:64596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol phosphorylceramide mannosyltransferase"
RHEA:52207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0032500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	muramyl dipeptide binding
REACT:R-DRE-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Danio rerio)
RHEA:17054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => beta-D-fructose 6-phosphate + D-erythrose 4-phosphate
RHEA:40817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-CFA-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Canis familiaris)
REACT:R-GGA-1306963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Gallus gallus)
REACT:R-GGA-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Gallus gallus)
RHEA:22418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + CO2 => 3,4-dihydroxybenzoate + H(+)
REACT:R-DRE-5655142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 binds POLH (Danio rerio)
REACT:R-DRE-2581474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK1,4,7 phosphorylate MII to p-MII (Danio rerio)
RHEA:20644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidinol + 2 NAD(+) <=> 3 H(+) + L-histidine + 2 NADH
RHEA:23182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ketone + H2O2 => a secondary alcohol + O2
RHEA:11674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine
REACT:R-HSA-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Homo sapiens)
REACT:R-SPO-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Schizosaccharomyces pombe)
RHEA:56548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
RHEA:10806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-allantoin => (S)-allantoin
REACT:R-RNO-3240295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Rattus norvegicus)
RHEA:39410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)
REACT:R-MMU-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Mus musculus)
REACT:R-MMU-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Mus musculus)
RHEA:39378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O
REACT:R-MMU-5675433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP5 dephosphorylates RAF1 S338 (Mus musculus)
REACT:R-HSA-380901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked serotonin loaded synaptic vesicle (Homo sapiens)
GO:0102759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campestanol hydroxylase activity
REACT:R-DRE-9773803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKBKB phosphorylates NF-kappa-B inhibitor  (Danio rerio)
RHEA:68758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine => 4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine
RHEA:63105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ilicicolin A epoxide + NADPH + O2 => 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)
RHEA:46970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + isopentenyldehydrorhodopin => A + dihydroisopentenyldehydrorhodopin
RHEA:16373	skos:altLabel	"pantothenate kinase (phosphorylating)"
RHEA:16373	skos:altLabel	"D-pantothenate kinase"
RHEA:16373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)
RHEA:16373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pantothenate kinase"
RHEA:16373	skos:altLabel	"ATP:pantothenate 4'-phosphotransferase"
RHEA:16373	skos:altLabel	"pantothenic acid kinase"
RHEA:16373	skos:prefLabel	"pantothenate kinase"
REACT:R-DRE-446130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 2 binds Interleukin 1 (Danio rerio)
REACT:R-SSC-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Sus scrofa)
RHEA:71156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoylpyruvate + H2O => (E)-caffeate + H(+) + pyruvate
REACT:R-GGA-374331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bradykinin receptors B1 and B2 bind to bradykinin (Gallus gallus)
RHEA:66506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:13314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + sarcosine => formaldehyde + glycine + H2O2
REACT:R-SCE-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Saccharomyces cerevisiae)
REACT:R-CEL-6794346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind NLGNs (Caenorhabditis elegans)
RHEA:20884	skos:altLabel	"L-serine:NAD oxidoreductase (deaminating)"
RHEA:20884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine + NAD(+) = 3-hydroxypyruvate + H(+) + NADH + NH4(+)
RHEA:20884	skos:prefLabel	"serine 2-dehydrogenase"
RHEA:20884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine 2-dehydrogenase"
RHEA:20884	skos:altLabel	"serine dehydrogenase"
RHEA:51744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)
REACT:R-BTA-8949661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Bos taurus)
REACT:R-GGA-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Gallus gallus)
REACT:R-CEL-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Caenorhabditis elegans)
REACT:R-HSA-9640321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-DKG hydrolyses to ERU and oxalate (Homo sapiens)
EC:3.2.1.65	skos:prefLabel	"levanase"
EC:3.2.1.65	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"levanase"
REACT:R-HSA-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:29990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(in) + H(+)(in) <=> adenosine(out) + H(+)(out)
REACT:R-CEL-5661120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Caenorhabditis elegans)
REACT:R-DRE-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)
RHEA:20387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+) => (2R,3R)-dihydroquercetin + H(+) + NADH + O2
REACT:R-DRE-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Danio rerio)
RHEA:49781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + glycine => CoA + H(+) + N-docosanoylglycine
RHEA:41383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene <=> 4-methylphenol + H2O + NAD(+)
REACT:R-CEL-5688276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT4 transfers ADPRib to GLUD (Caenorhabditis elegans)
REACT:R-HSA-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)
RHEA:23080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O
RHEA:23080	skos:prefLabel	"L-rhamnonate dehydratase"
RHEA:23080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-rhamnonate dehydratase"
RHEA:44606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O
GO:0045547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrodolichyl diphosphate synthase activity
RHEA:64517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate + NAD(+) => H(+) + NADH + sulfoacetaldehyde
REACT:R-DRE-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Danio rerio)
REACT:R-HSA-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)
RHEA:59653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotetraono-1,5-lactone + H2O => D-xylotetraonate + H(+)
RHEA:68626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] => phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]
REACT:R-HSA-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Homo sapiens)
GO:0008889	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IgD-binding protein D
GO:0008889	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphodiester glycerophosphohydrolase activity
GO:0008889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophosphodiester phosphodiesterase activity
GO:0008889	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphoryl diester phosphodiesterase activity
GO:0008889	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gene hpd protein
REACT:R-XTR-210291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Xenopus tropicalis)
EC:2.4.1.364	skos:altLabel	"UGT74AE2"
EC:2.4.1.364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protopanaxadiol-type ginsenoside 3-O-glucosyltransferase"
EC:2.4.1.364	skos:prefLabel	"protopanaxadiol-type ginsenoside 3-O-glucosyltransferase"
REACT:R-SSC-2130151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of DAP12 (Sus scrofa)
RHEA:24907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine => (E)-4-coumarate + NH4(+)
REACT:R-CFA-8943959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP9 cleave SCUBE3 (Canis familiaris)
REACT:R-CEL-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-CFA-192331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Canis familiaris)
GO:0036133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxythromboxane B2 dehydrogenase activity
GO:0036133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity
RHEA:70389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octadecanoyl-3-oxosphinganine => 3-oxosphinganine + octadecanoyl-CoA
GO:0015095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	magnesium ion transmembrane transporter activity
REACT:R-BTA-9613264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Bos taurus)
RHEA:52285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DRE-175983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfer CH3 from AdoMet to 3,4DHBNZ (Danio rerio)
EC:1.5.3.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"non-specific polyamine oxidase"
EC:1.5.3.17	skos:altLabel	"polyamine oxidase"
EC:1.5.3.17	skos:prefLabel	"non-specific polyamine oxidase"
REACT:R-DRE-5665802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Danio rerio)
REACT:R-GGA-9698844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds HSP90:CDC37 (Gallus gallus)
REACT:R-BTA-975097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
REACT:R-RNO-381435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)
REACT:R-DRE-5634228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 is cleaved by caspases (Danio rerio)
RHEA:58340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
GO:0036193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity
RHEA:45525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]
REACT:R-CFA-265424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Canis familiaris)
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoprotease activity involved in amyloid precursor protein catabolic process
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoprotease activity involved in APP catabolism
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoprotease activity involved in amyloid precursor protein breakdown
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloendopeptidase activity involved in amyloid precursor protein breakdown
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoproteinase activity involved in APP catabolic process
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoproteinase activity involved in amyloid precursor protein degradation
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoproteinase activity involved in APP catabolism
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoprotease activity involved in amyloid precursor protein degradation
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloendopeptidase activity involved in APP catabolic process
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoproteinase activity involved in amyloid precursor protein catabolism
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloendopeptidase activity involved in amyloid precursor protein degradation
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoprotease activity involved in APP catabolic process
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoproteinase activity involved in amyloid precursor protein catabolic process
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAM10:Zn2+:TSPANs cleaves APP(18-770) (Homo sapiens)
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloendopeptidase activity involved in amyloid precursor protein catabolism
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloendopeptidase activity involved in APP catabolism
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoproteinase activity involved in amyloid precursor protein breakdown
GO:1902945	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoprotease activity involved in amyloid precursor protein catabolism
REACT:R-GGA-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Gallus gallus)
GO:0034526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylnaphthalene hydroxylase activity
RHEA:33186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) <=> citrate(out)
REACT:R-DRE-3907292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Danio rerio)
REACT:R-SSC-140825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Sus scrofa)
RHEA:64867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITP + oxaloacetate <=> CO2 + IDP + phosphoenolpyruvate
RHEA:25229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NADP(+) = H(+) + L-arabinose + NADPH
REACT:R-XTR-2730847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
REACT:R-DRE-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Danio rerio)
RHEA:55244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-HSA-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
GO:0019165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:thiamine phosphotransferase activity
GO:0019165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin kinase activity
GO:0019165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:thiamin phosphotransferase activity
GO:0019165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine kinase activity
GO:0019165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin kinase (phosphorylating)
GO:0019165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin phosphokinase activity
RHEA:64994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine => acetyl-CoA + H2O
RHEA:65736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + octyl sulfate = CO2 + H(+) + octanal + succinate + sulfate
REACT:R-CEL-8854044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)
RHEA:47297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-DDI-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Dictyostelium discoideum)
REACT:R-DRE-3928645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB:NMDAR binds TIAM1 (Danio rerio)
RHEA:25453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + germacrene A
RHEA:70690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) <=> 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)
REACT:R-XTR-8864125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Xenopus tropicalis)
RHEA:44882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-threonyl-[receptor-protein] => ATP + L-threonyl-[receptor-protein]
RHEA:42507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-acetyl-L-lysine <=> 6-acetamido-2-oxohexanoate + L-glutamate
REACT:R-DME-77329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Drosophila melanogaster)
RHEA:31929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Rattus norvegicus)
REACT:R-HSA-8939833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2:CBFB binds the ITGBL1 gene promoter (Homo sapiens)
REACT:R-SPO-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Schizosaccharomyces pombe)
GO:0050084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannitol-1-phosphate phosphohydrolase activity
GO:0050084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannitol-1-phosphate phosphatase activity
GO:0050084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannitol-1-phosphatase activity
GO:0036139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-histidine dioxygenase activity
REACT:R-RNO-201423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI complexes with the Smad complex, suppressing BMP2 signalling (Rattus norvegicus)
RHEA:32648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin C + S-adenosyl-L-methionine => erythromycin A + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-5205820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Mus musculus)
REACT:R-XTR-5693536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDC1 (Xenopus tropicalis)
RHEA:16576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-(phosphooxy)-L-threonine <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate
REACT:R-MMU-2731141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds fibronectin (Mus musculus)
REACT:R-PFA-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Plasmodium falciparum)
RHEA:17465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + quercitrin = L-rhamnopyranose + quercetin
RHEA:17465	skos:prefLabel	"alpha-L-rhamnosidase"
RHEA:17465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-L-rhamnosidase"
RHEA:56790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)alamin
RHEA:61976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]
REACT:R-GGA-2132260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I inactivates surface-bound C3b (Gallus gallus)
REACT:R-DDI-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Dictyostelium discoideum)
RHEA:21857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexa-1,5-diene-1-carbonyl-CoA + H2O => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA
RHEA:64529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine
RHEA:37555	skos:prefLabel	"kanosamine-6-phosphate phosphatase"
RHEA:37555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kanosamine-6-phosphate phosphatase"
RHEA:37555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-kanosamine 6-phosphate + H2O = kanosamine + phosphate
REACT:R-MMU-2197646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1 (SR-BI, CLA-1) binds ligands (Mus musculus)
RHEA:40975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine
RHEA:49852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-octenoyl-CoA = (2E)-octenoyl-CoA
REACT:R-DME-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Drosophila melanogaster)
REACT:R-HSA-8950771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SOD1 (Homo sapiens)
REACT:R-CFA-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Canis familiaris)
RHEA:69873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-1168633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB translocates from the cytosol to the nucleus (Bos taurus)
RHEA:13937	skos:prefLabel	"4-sulfobenzoate 3,4-dioxygenase"
RHEA:13937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulfobenzoate + NADH + O2 = 3,4-dihydroxybenzoate + NAD(+) + sulfite
RHEA:13937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-sulfobenzoate 3,4-dioxygenase"
REACT:R-GGA-8875576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK,CRKL recruits RAC1 GEF to activated MET (Gallus gallus)
RHEA:52661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + ATP + holo-[ACP] => AMP + an L-alpha-aminoacyl-[ACP] + diphosphate
REACT:R-BTA-8941613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
REACT:R-BTA-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Bos taurus)
RHEA:41415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)
GO:0102254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity
RHEA:47521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isolithocholate + NADP(+)
REACT:R-HSA-3928588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs binds PTK2 (Homo sapiens)
RHEA:24410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + NH4(+) => adenosine + H(+) + H2O
RHEA:42922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1498) in 16S rRNA
GO:0044693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose:hydrogen symporter activity
GO:0044693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose:proton symporter activity
RHEA:54339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:66154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetylnoradrenaline => acetyl-CoA + noradrenaline
RHEA:54757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deamido-NAD(+) + hydrogencarbonate => AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide
REACT:R-DDI-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Dictyostelium discoideum)
RHEA:35302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoyl-CoA + NADP(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADPH
RHEA:47039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine in 5S rRNA <=> pseudouridine in 5S rRNA
REACT:R-SSC-264997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cysteine to cystine in Proinsulin (Sus scrofa)
RHEA:56174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-formylriboflavin 5'-phosphate + H2O => FMN + O2
REACT:R-BTA-428007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled histidine and di-peptide cotransport (Bos taurus)
REACT:R-DME-1475032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Drosophila melanogaster)
REACT:R-BTA-933536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7 dimer interacts with coactivator CBP/p300 (Bos taurus)
RHEA:48229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]
REACT:R-DRE-8964604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Danio rerio)
REACT:R-XTR-749456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Xenopus tropicalis)
GO:0004492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl/ethyl malonyl-CoA decarboxylase activity
GO:0004492	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)
GO:0004492	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methylmalonyl-coenzyme A decarboxylase activity
GO:0004492	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity
GO:0004492	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	(S)-methylmalonyl-CoA carboxy-lyase activity
GO:0004492	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ethylmalonyl-CoA decarboxylase activity
RHEA:37696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA => 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-SSC-8948034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds LDL:LRP8 (Sus scrofa)
RHEA:48937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]
REACT:R-HSA-140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Homo sapiens)
REACT:R-MMU-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Mus musculus)
RHEA:72163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)
REACT:R-HSA-3229213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCVRN:Ca2+ binds to and inhibits GRK1 (Homo sapiens)
RHEA:30781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + FADH2 => D-gluconate + FAD + H(+)
REACT:R-GGA-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Gallus gallus)
REACT:R-HSA-9694592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3CLp dimer binds 3CLp inhibitors (Homo sapiens)
REACT:R-RNO-209765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)
REACT:R-RNO-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Rattus norvegicus)
RHEA:55367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 6 diphosphate
RHEA:47563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) <=> CMP + ganglioside GM1b (d18:1(4E)) + H(+)
REACT:R-HSA-9700175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates SHC1 (Homo sapiens)
REACT:R-BTA-8944261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIII (Bos taurus)
RHEA:31277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonate semialdehyde + H(+) + NADH => (S)-3-hydroxy-2-methylpropanoate + NAD(+)
REACT:R-HSA-167148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
REACT:R-RNO-352108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Rattus norvegicus)
REACT:R-RNO-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Rattus norvegicus)
RHEA:16158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[leghemoglobin] + NADPH => 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)
REACT:R-GGA-5654569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS2 (Gallus gallus)
GO:0017069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small nuclear RNA binding
GO:0017069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA binding
GO:0017069	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	base pairing with snRNA
RHEA:33932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + O2 => (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal
REACT:R-SPO-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Schizosaccharomyces pombe)
REACT:R-GGA-390641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA1A,B,D bind ADR,NAd (Gallus gallus)
REACT:R-GGA-2187261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC12 (SCARA4) binds ligands (Gallus gallus)
REACT:R-HSA-201790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)
REACT:R-SCE-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Saccharomyces cerevisiae)
REACT:R-XTR-9707977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Xenopus tropicalis)
RHEA:40910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-DDI-76434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of carbon tetrachloride to form a free radical (Dictyostelium discoideum)
REACT:R-BTA-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Bos taurus)
REACT:R-SSC-1678650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses Heparan sulfate chain(5) (Sus scrofa)
RHEA:51158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Glu)
RHEA:65056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH
REACT:R-DRE-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Danio rerio)
REACT:R-SCE-450490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B/Akt phosphorylates BRF1 (Saccharomyces cerevisiae)
REACT:R-HSA-168933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of phosphorylated IRF3/IRF7 (Homo sapiens)
REACT:R-BTA-114684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Syntaxin-4 (Bos taurus)
REACT:R-GGA-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Gallus gallus)
REACT:R-DDI-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Dictyostelium discoideum)
REACT:R-SCE-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Saccharomyces cerevisiae)
REACT:R-SSC-416690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4A binds to PLXND1 (Sus scrofa)
REACT:R-MMU-70679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 oxidises L-GluSS to Glu (Mus musculus)
RHEA:67818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate => a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O
REACT:R-DME-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Drosophila melanogaster)
RHEA:68221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol => (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA
REACT:R-GGA-191654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-src associates with Cx43 in gap junctions (Gallus gallus)
GO:0043827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (adenine-57, 58-N(1)-) methyltransferase activity
GO:0043827	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tRNA (m1A) MTase
GO:0043827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TrmI
GO:0043827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (adenine-57, 58 N1-) methyltransferase activity
GO:0043827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (adenine-57, 58-N1-) methyltransferase activity
REACT:R-BTA-5662692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is oxidized to dopaquinone by TYR (Bos taurus)
REACT:R-RNO-380455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CDK11p58 to the centrosomes (Rattus norvegicus)
REACT:R-CFA-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Canis familiaris)
REACT:R-RNO-216727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Rattus norvegicus)
REACT:R-MMU-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)
RHEA:59517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylsalicylate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate
GO:0016784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-mercaptopyruvate sulphurtransferase activity
GO:0016784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-mercaptopyruvate sulfurtransferase activity
GO:0016784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-mercaptopyruvate sulfurtransferase activity
GO:0016784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mercaptopyruvate sulfurtransferase activity
GO:0016784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-mercaptopyruvate:cyanide sulfurtransferase activity
RHEA:39494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)
REACT:R-DDI-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Dictyostelium discoideum)
REACT:R-RNO-400097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-beta:G-gamma inhibits Adenylate cyclase (Rattus norvegicus)
RHEA:19024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP
GO:0047778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[citrate-(pro-3S)-lyase] thiolesterase activity
GO:0047778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[citrate-(pro-3S)-lyase] thioesterase activity
GO:0047778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate (pro-3S)-lyase thiolesterase activity
GO:0047778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate lyase deacetylase activity
GO:0047778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate-(pro-3S)-lyase thioesterase activity
GO:0047778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity
GO:0047778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate-(pro-3S)-lyase thiolesterase activity
REACT:R-CEL-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Caenorhabditis elegans)
RHEA:35881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-BTA-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Bos taurus)
REACT:R-GGA-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Gallus gallus)
GO:0050230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)
GO:0050230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine imidazole-ring cyclase activity
GO:0050230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)
GO:0050230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)
RHEA:14122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-73632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Canis familiaris)
REACT:R-RNO-372480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Rattus norvegicus)
RHEA:26164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + echinenone + O2 = 4'-hydroxyechinenone + A + H2O
RHEA:18564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH
REACT:R-GGA-5218826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Gallus gallus)
GO:0015175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral amino acid transmembrane transporter activity
GO:0015175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral L-amino acid transmembrane transporter activity
GO:0015175	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	neutral amino acid transporter activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine-sulfinate decarboxylase activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-sulfino-L-alanine carboxy-lyase activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteinesulfinic acid decarboxylase activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteic decarboxylase activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteinesulfinate decarboxylase activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfinoalanine decarboxylase activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfoalanine decarboxylase activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CSAD
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteinesulfinic acid decarboxylase activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphinoalanine decarboxylase activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CSADCase activity
GO:0004782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CADCase/CSADCase activity
REACT:R-MMU-983142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of peptide loading complex (PLC) (Mus musculus)
RHEA:32751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline(out) = choline(in)
RHEA:56434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-DDI-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Dictyostelium discoideum)
GO:0018565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxydibenzothiophene dioxygenase activity
REACT:R-HSA-8983688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAS1 oligomerizes (Homo sapiens)
REACT:R-XTR-2022412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)
REACT:R-RNO-73718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBF-1 Binds rDNA Promoter (Rattus norvegicus)
RHEA:30662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(phosphooxy)-L-threonine + H2O <=> 4-hydroxy-L-threonine + phosphate
RHEA:64023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-seryl-[protein] <=> GDP + H(+) + O-phospho-L-seryl-[protein]
REACT:R-BTA-4086088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO1 (Bos taurus)
RHEA:38908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + S-adenosyl-L-methionine => (R)-laudanine + H(+) + S-adenosyl-L-homocysteine
RHEA:13208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monosaccharide 1-phosphate + H(+) + UTP <=> a UDP-monosaccharide + diphosphate
RHEA:71525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine(in) => adenine(out)
REACT:R-HSA-176669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Homo sapiens)
REACT:R-GGA-416559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)
REACT:R-DME-193691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kB migrates to the nucleus and turns on transcription (Drosophila melanogaster)
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloartenol + S-adenosyl-L-methionine = 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine
GO:0003838	skos:altLabel	"phytosterol methyltransferase"
GO:0003838	skos:altLabel	"SMT1"
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	zymosterol-24-methyltransferase activity
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol 24-C-methyltransferase activity
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + zymosterol = fecosterol + H(+) + S-adenosyl-L-homocysteine
GO:0003838	skos:altLabel	"Delta(24)-sterol methyltransferase"
GO:0003838	skos:altLabel	"S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase"
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta24-sterol methyltransferase activity
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity
GO:0003838	skos:altLabel	"24-sterol C-methyltransferase"
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity
GO:0003838	skos:altLabel	"Delta(24)-methyltransferase"
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phytosterol methyltransferase activity
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-4-methionine:sterol delta24-methyltransferase activity
GO:0003838	skos:altLabel	"S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase"
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sterol 24-C-methyltransferase"
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta(24)-sterol C-methyltransferase activity
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol 24C methyltransferase activity
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(24)-methyltransferase activity
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SMT1 activity
GO:0003838	skos:prefLabel	"sterol 24-C-methyltransferase"
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	24-sterol C-methyltransferase activity
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta24-methyltransferase activity
GO:0003838	skos:altLabel	"zymosterol-24-methyltransferase"
GO:0003838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(24)-sterol methyltransferase activity
REACT:R-RNO-5654662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
REACT:R-SSC-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Sus scrofa)
GO:0016625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With an iron-sulfur protein as acceptor"
GO:0016625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor
GO:0016625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
GO:0016625	skos:prefLabel	"With an iron-sulfur protein as acceptor"
REACT:R-SSC-6788999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HV1-mediated H+ transfer (Sus scrofa)
REACT:R-SSC-193656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with RIP2 (Sus scrofa)
RHEA:56010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)
RHEA:35307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salicylate 5-hydroxylase"
RHEA:35307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + salicylate = 2,5-dihydroxybenzoate + H2O + NAD(+)
RHEA:35307	skos:prefLabel	"salicylate 5-hydroxylase"
RHEA:37466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-CFA-2089971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of collagens (Canis familiaris)
REACT:R-BTA-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Bos taurus)
RHEA:31734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O
EC:3.2.1.76	skos:prefLabel	"L-iduronidase"
EC:3.2.1.76	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-iduronidase"
RHEA:48188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:21031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]
RHEA:15127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n)
RHEA:45046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + nitrite => 2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2
REACT:R-BTA-378513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Bos taurus)
RHEA:37089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine
RHEA:59533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + S-adenosyl-L-methionine => (S)-codamine + H(+) + S-adenosyl-L-homocysteine
GO:0008504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoamine transmembrane transporter activity
REACT:R-DRE-140847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Danio rerio)
RHEA:49294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein] => D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein]
GO:1901602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dethiobiotin binding
RHEA:39948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)
RHEA:14304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxolactone + H2O <=> 4-pyridoxate + H(+)
REACT:R-CEL-2168038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XV restin release (Caenorhabditis elegans)
RHEA:41586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-dimethylallyl-L-tyrosine + diphosphate => dimethylallyl diphosphate + L-tyrosine
RHEA:69069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline => A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide
RHEA:21275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione + spermidine <=> ADP + glutathionylspermidine + H(+) + phosphate
REACT:R-HSA-9630053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTHL1 D239Y does not cleave thymine glycol (Tg) (Homo sapiens)
RHEA:69474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose
REACT:R-HSA-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
RHEA:38566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + H2O <=> 1-O-hexadecyl-sn-glycerol + acetate + H(+)
REACT:R-DRE-9629216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Danio rerio)
REACT:R-HSA-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)
REACT:R-SSC-8950398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX dissociates from IL27:EBI3 (Sus scrofa)
REACT:R-CEL-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)
GO:0009045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose aldose-ketose-isomerase activity
GO:0009045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose ketoisomerase activity
GO:0009045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylose isomerase activity
GO:0009045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose isomerase activity
GO:0009045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose ketol-isomerase activity
RHEA:72813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)
RHEA:13833	skos:prefLabel	"arginine--pyruvate transaminase"
RHEA:13833	skos:altLabel	"arginine:pyruvate transaminase"
RHEA:13833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine
RHEA:13833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginine--pyruvate transaminase"
REACT:R-RNO-198824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Rattus norvegicus)
REACT:R-HSA-4827383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Homo sapiens)
RHEA:19195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-retinol => A + all-trans-13,14-dihydroretinol
RHEA:25324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
REACT:R-HSA-5419277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)
RHEA:46771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-997326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Rattus norvegicus)
REACT:R-SSC-983146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Sus scrofa)
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vacuolar-type Na+-translocating ATPase
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Na(+)-transporting two-sector ATPase activity
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium transporting ATPase activity, rotational mechanism
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sodium-translocating V-type ATPase activity
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Na+-translocating F1Fo-ATPase
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-transporting ATPase activity, rotational mechanism
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Na(+)-translocating ATPase activity
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Na+-transporting two-sector ATPase
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Na+-translocating ATPase activity
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP phosphohydrolase (Na+-transporting) activity
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sodium-transporting two-sector ATPase activity
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vacuolar-type Na+-ATPase
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sodium-translocating F-type ATPase activity
GO:0046962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP synthase, sodium ion specific activity
GO:0062145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-propargylglycine = ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate
GO:0062145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-propargylglycine--L-glutamate ligase activity
REACT:R-BTA-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Bos taurus)
RHEA:46214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-aminomethyl-2-methylpyrimidine + formate => H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine
REACT:R-MMU-2872498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Mus musculus)
REACT:R-XTR-9759206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Xenopus tropicalis)
REACT:R-MMU-3769397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOST binds LRP5/6 (Mus musculus)
RHEA:71498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)
RHEA:44970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H(+) + NADPH
RHEA:36919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA
REACT:R-HSA-71541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Homo sapiens)
RHEA:64366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-15-hydroperoxy-prostaglandin E2 => prostaglandin G2
REACT:R-HSA-158333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Homo sapiens)
REACT:R-BTA-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Bos taurus)
RHEA:12824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate <=> acetaldehyde + D-glyceraldehyde 3-phosphate
REACT:R-MMU-9757706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Mus musculus)
REACT:R-BTA-193787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Bos taurus)
GO:0015226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine transmembrane transporter activity
GO:0015226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin Bt transporter activity
GO:0015226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-HSA-211224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with DFF45 (Homo sapiens)
RHEA:30945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + FADH2 => FAD + H(+) + octanoyl-CoA
RHEA:34720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine 1-phosphate => (2E)-13-methyltetradecenal + phosphoethanolamine
REACT:R-MMU-9674816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Mus musculus)
RHEA:60759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone <=> cinerin I + CoA
RHEA:72856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + dADP(in) => ADP(in) + dADP(out)
REACT:R-MMU-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Mus musculus)
REACT:R-DRE-1855200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Danio rerio)
RHEA:66322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP(in) => 2',3'-cGAMP(out)
RHEA:19111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+) => 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose
GO:0016289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA hydrolase activity
GO:0016289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of choloyl-CoA to cholate and CoASH (Homo sapiens)
REACT:R-MMU-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Mus musculus)
REACT:R-RNO-982807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation of GHR (Rattus norvegicus)
RHEA:63789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-XTR-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Xenopus tropicalis)
REACT:R-RNO-9020278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Rattus norvegicus)
RHEA:46038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H(+) + UDP => 2'-deoxycytidine + UTP
REACT:R-HSA-74882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT1-GDP binds to GNB1:GNGT1 (Homo sapiens)
RHEA:39738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9706336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SYK (Mus musculus)
RHEA:19112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose <=> 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)
REACT:R-SCE-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Saccharomyces cerevisiae)
REACT:R-RNO-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Rattus norvegicus)
RHEA:18058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + Watasenia luciferin => CO2 + hnu + oxidized Watasenia luciferin
RHEA:61102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:28555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate + H2O => D-mannose + phosphate
RHEA:37622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:70338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-L-lyxonolactone + H2O <=> 2-carboxy-L-lyxonate + H(+)
REACT:R-SPO-1482868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Schizosaccharomyces pombe)
GO:1990606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	membrane scission GTPase motor activity
REACT:R-HSA-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Homo sapiens)
REACT:R-RNO-8950410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B:IL12B translocates from ER lumen to the extracellular region (Rattus norvegicus)
RHEA:67423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid + H2O <=> a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)
REACT:R-GGA-448661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)
RHEA:72145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + GTP + S-adenosyl-L-methionine
RHEA:67653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dADP + H2O => 2'-deoxyadenosine + diphosphate
REACT:R-DME-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Drosophila melanogaster)
RHEA:12055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + trichodiene
REACT:R-DRE-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Danio rerio)
REACT:R-MMU-8857662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Mus musculus)
REACT:R-XTR-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)
RHEA:58068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + trans-isoeugenol = acetaldehyde + vanillin
RHEA:58068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoeugenol monooxygenase"
RHEA:58068	skos:prefLabel	"isoeugenol monooxygenase"
RHEA:69809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + benzoyl-CoA + H(+) => benzoyl-AMP + CoA
REACT:R-CFA-9714480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the mitochondrial membrane (Canis familiaris)
RHEA:65538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + theacrine => 1,3,7-trimethylurate + S-adenosyl-L-methionine
REACT:R-MMU-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Mus musculus)
REACT:R-MMU-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Mus musculus)
RHEA:28773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA => (2E)-hexadecenoyl-CoA
REACT:R-SSC-8855381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dephosphorylates ZAP70 (Sus scrofa)
REACT:R-DDI-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Dictyostelium discoideum)
REACT:R-RNO-2022396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-43) (Rattus norvegicus)
REACT:R-SCE-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Saccharomyces cerevisiae)
REACT:R-SSC-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Sus scrofa)
GO:0052589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate:menaquinone oxidoreductase activity
GO:0052589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate:(menaquinone) oxidoreductase activity
GO:0052589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate dehydrogenase (menaquinone) activity
REACT:R-RNO-9021068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs bind CAVs (Rattus norvegicus)
REACT:R-RNO-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Rattus norvegicus)
REACT:R-RNO-71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Rattus norvegicus)
REACT:R-RNO-9609742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Rattus norvegicus)
REACT:R-MMU-109998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Mus musculus)
REACT:R-CEL-1475028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Caenorhabditis elegans)
RHEA:61652	skos:prefLabel	"2,3-dihydroxybenzoate--[aryl-carrier protein] ligase"
RHEA:61652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate
RHEA:61652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-dihydroxybenzoate--[aryl-carrier protein] ligase"
RHEA:10916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate = all-trans-phytoene + diphosphate
REACT:R-MMU-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Mus musculus)
RHEA:32662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + 2 NADP(+) <=> (6E)-8-oxogeranial + 2 H(+) + 2 NADPH
REACT:R-DRE-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Danio rerio)
REACT:R-HSA-204861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shc1 (Homo sapiens)
GO:0140161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monocarboxylate:sodium symporter activity
REACT:R-BTA-3239019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK5 (Bos taurus)
REACT:R-GGA-4551768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO2,3 (Gallus gallus)
RHEA:13515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + orotate => (S)-dihydroorotate + NAD(+)
RHEA:72075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine = ADP + H(+) + ophthalmate + phosphate
GO:1901982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose binding
REACT:R-MMU-74730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin degradation (Mus musculus)
RHEA:11074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + CO2 + NADP(+) + NH4(+) => anthranilate + 3 H(+) + NADPH + O2
RHEA:42995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (R)-nephthenol + diphosphate
REACT:R-BTA-5357429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL autophosphorylates on Y772 and Y814 (Bos taurus)
GO:0090409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA synthetase activity
RHEA:16015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + glycyl-tRNA(Gly) => ATP + glycine + tRNA(Gly)
REACT:R-SSC-74746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y427-SHC1 (Sus scrofa)
REACT:R-GGA-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Gallus gallus)
RHEA:60659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline
REACT:R-DRE-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Danio rerio)
RHEA:47113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + glycine => glycochenodeoxycholate + H2O
REACT:R-BTA-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Bos taurus)
RHEA:13537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosyl-3-phosphoglycerate synthase"
RHEA:13537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)
RHEA:13537	skos:prefLabel	"mannosyl-3-phosphoglycerate synthase"
RHEA:13537	skos:altLabel	"MPG synthase"
RHEA:16366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digallate + H2O => 2 3,4,5-trihydroxybenzoate + H(+)
REACT:R-BTA-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Bos taurus)
RHEA:70500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(out) + 2 Na(+)(out) => D-galactose(in) + 2 Na(+)(in)
RHEA:22100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4(+)
RHEA:22100	skos:prefLabel	"bromoxynil nitrilase"
RHEA:22100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bromoxynil nitrilase"
GO:0034891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endosulfan diol dehydrogenase activity
REACT:R-MMU-5635864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH ubiquitinates GLI1 (Mus musculus)
GO:0106231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
GO:0106231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-propionyllysine depropionylase activity
RHEA:56909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-O-acetylsalutaridinol => acetate + H(+) + thebaine
REACT:R-CEL-112435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin BC complex (Caenorhabditis elegans)
REACT:R-HSA-374677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds ERM family members (Homo sapiens)
RHEA:34739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine = H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine
RHEA:57269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + H(+) + lactate
REACT:R-RNO-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Rattus norvegicus)
RHEA:23127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2R)-3-phosphoglycerate + 2 H(+) <=> CO2 + D-ribulose 1,5-bisphosphate + H2O
REACT:R-CEL-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Caenorhabditis elegans)
RHEA:31883	skos:prefLabel	"delta-amyrin synthase"
RHEA:31883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = delta-amyrin
RHEA:31883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"delta-amyrin synthase"
RHEA:60239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate
RHEA:63517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2',3-triol + H(+) + NADH + O2 => biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)
REACT:R-MMU-212004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Mus musculus)
RHEA:37771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:37501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
GO:0016846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-sulfur lyase activity
GO:0016846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-sulphur lyase activity
REACT:R-XTR-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Xenopus tropicalis)
REACT:R-CFA-163733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of FAS monomer gene by ChREBP:MLX (Canis familiaris)
REACT:R-DRE-266012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTD4 is converted to LTE4 by DPEP1/2 (Danio rerio)
REACT:R-SSC-5693055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Sus scrofa)
GO:0001164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase I CORE element sequence-specific DNA binding
GO:0001164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting
GO:0001164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase I core promoter sequence-specific DNA binding
GO:0001164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity
REACT:R-RNO-9028255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises EPA to PGH3 (Rattus norvegicus)
REACT:R-CFA-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)
REACT:R-RNO-114558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate Gq (Rattus norvegicus)
REACT:R-MMU-193073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Mus musculus)
RHEA:11959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-glucoside + H2O <=> cholesterol + D-glucose
REACT:R-SSC-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Sus scrofa)
REACT:R-RNO-5607751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes (Rattus norvegicus)
RHEA:11636	skos:prefLabel	"15-hydroxyprostaglandin dehydrogenase (NADP(+))"
RHEA:11636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"15-hydroxyprostaglandin dehydrogenase (NADP(+))"
RHEA:11636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADPH
REACT:R-DME-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Drosophila melanogaster)
GO:0008682	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	demethoxy-ubiquinone hydroxylase
GO:0008682	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	demethoxyubiquinone monooxygenase
GO:0008682	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity
GO:0008682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethoxyubiquinol 3-hydroxylase activity
REACT:R-HSA-1629787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Cx26 (Homo sapiens)
RHEA:14694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP
REACT:R-CFA-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Canis familiaris)
RHEA:25626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + histamine + O2 => H2O2 + imidazole-4-acetaldehyde + NH4(+)
REACT:R-DDI-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Dictyostelium discoideum)
REACT:R-CFA-193669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to p75NTR:NRIF (Canis familiaris)
REACT:R-DRE-1971491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Danio rerio)
RHEA:46546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:61362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + pheophorbide a(out) + phosphate => ATP + H2O + pheophorbide a(in)
RHEA:59793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + yersinopine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate
REACT:R-MMU-8956676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TP73 (Mus musculus)
REACT:R-SSC-8878581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYRP1 oxidises DHICA to IQCA (Sus scrofa)
REACT:R-GGA-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Gallus gallus)
RHEA:13957	skos:prefLabel	"sulfur oxygenase/reductase"
RHEA:13957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfur oxygenase/reductase"
RHEA:13957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H2O + O2 + 4 sulfur = 6 H(+) + 2 hydrogen sulfide + 2 sulfite
RHEA:13957	skos:altLabel	"sulfur oxygenase reductase"
RHEA:13957	skos:altLabel	"sulfur oxygenase"
REACT:R-SCE-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Saccharomyces cerevisiae)
RHEA:45983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)
RHEA:63783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine
REACT:R-CEL-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Caenorhabditis elegans)
RHEA:65157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + preaustinoid A2 => CO2 + H2O + preaustinoid A3 + succinate
GO:0018669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate 6-monooxygenase activity
GO:0018669	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybenzoic acid-6-hydroxylase activity
GO:0018669	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	m-hydroxybenzoate 6-hydroxylase activity
GO:0018669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate 6-hydroxylase activity
GO:0018669	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)
REACT:R-SSC-4641246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 autoubiquitinates to promote its internalization (Sus scrofa)
RHEA:58298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine
REACT:R-XTR-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Xenopus tropicalis)
REACT:R-CEL-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Caenorhabditis elegans)
RHEA:71245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + hypotaurine(in) + 2 Na(+)(in) => chloride(out) + hypotaurine(out) + 2 Na(+)(out)
REACT:R-DRE-77303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Danio rerio)
REACT:R-MMU-5607004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds PRTN3:CD177 (Mus musculus)
REACT:R-HSA-9683648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike trimer glycoside chains are extended (Homo sapiens)
RHEA:54358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanal + CO2 => 3-methyl-2-oxobutanoate + H(+)
GO:0005342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organic acid transmembrane transporter activity
REACT:R-HSA-9665410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 (Homo sapiens)
RHEA:40934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ornithine + O2 <=> (3S)-3-hydroxy-L-ornithine + CO2 + succinate
RHEA:58815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate <=> AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
RHEA:19398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + CTP + L-cysteine => CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
RHEA:13458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) => (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2
REACT:R-BTA-203973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle budding (Bos taurus)
REACT:R-HSA-9008137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds ZNF521 and HDAC3 (Homo sapiens)
REACT:R-HSA-9022770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds SGK1 gene promoter (Homo sapiens)
RHEA:41015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA
REACT:R-HSA-373706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Contactin-1 (CNTN1) binds NOTCH1 (Homo sapiens)
RHEA:46679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) <=> (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH
RHEA:40617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-didecanoyl-sn-glycerol + decanoate + H(+) => H2O + tridecanoylglycerol
RHEA:18229	skos:prefLabel	"glyoxylate reductase"
RHEA:18229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + NAD(+) = glyoxylate + H(+) + NADH
RHEA:18229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyoxylate reductase"
RHEA:18229	skos:altLabel	"glycolate reductase"
RHEA:18229	skos:altLabel	"NADH-dependent glyoxylate reductase"
RHEA:18229	skos:altLabel	"glyoxylic acid reductase"
RHEA:16011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + formyl phosphate => ATP + formate
REACT:R-DDI-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Dictyostelium discoideum)
REACT:R-CFA-2187358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters unphosphorylated SMAD2/3 (Canis familiaris)
REACT:R-SSC-2562526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates OPTN (Sus scrofa)
RHEA:33810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + H(+) <=> 2-methoxy-4-vinylphenol + CO2
REACT:R-GGA-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Gallus gallus)
RHEA:23123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dipeptide(out) + ATP + H2O <=> a dipeptide(in) + ADP + H(+) + phosphate
RHEA:41152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)
REACT:R-DRE-5252041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Danio rerio)
RHEA:48524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GP1c + H2O = ganglioside GQ1c + N-acetylneuraminate
REACT:R-DRE-5686430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81 binds EME1, EME2 (Danio rerio)
RHEA:59561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N',N''-triacetylchitotriono-1,5-lactone => H(+) + N,N',N''-triacetylchitotrionate
REACT:R-CEL-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Caenorhabditis elegans)
REACT:R-RNO-5683425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53BP1 at DNA DSBs (Rattus norvegicus)
REACT:R-HSA-9755777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 M, N bind to PDPK1 (Homo sapiens)
REACT:R-MMU-9624526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Mus musculus)
REACT:R-HSA-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Homo sapiens)
REACT:R-CFA-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Canis familiaris)
REACT:R-DRE-9012761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI binds RHOA-GDI (Danio rerio)
REACT:R-SCE-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Saccharomyces cerevisiae)
REACT:R-XTR-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Xenopus tropicalis)
RHEA:28794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + NAD(+) <=> H(+) + NADH + thymine
REACT:R-GGA-6783530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gp130:JAKs bind CNTFR (Gallus gallus)
REACT:R-BTA-192341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)
REACT:R-DME-8853774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Drosophila melanogaster)
REACT:R-CFA-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)
REACT:R-CFA-442368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
RHEA:72109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) + O-acyl-(R)-carnitine(in) => Na(+)(out) + O-acyl-(R)-carnitine(out)
RHEA:23231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NADPH + O2 <=> H2O + N(6)-hydroxy-L-lysine + NADP(+)
RHEA:51295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(S)-S-oxide-[protein]
REACT:R-CFA-1678660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan sulfate chain(3) (Canis familiaris)
RHEA:15379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+) => (S)-4,5-dihydroxypentane-2,3-dione + ATP
RHEA:31061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + imidazole-4-acetate + NADH => H2O + imidazole-4-acetaldehyde + NAD(+)
REACT:R-XTR-5693539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of DNA and formation of Holliday structures following repair synthesis (Xenopus tropicalis)
REACT:R-RNO-5687360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLL or POLM extends aligned DNA DSB ends to fill gaps (Rattus norvegicus)
RHEA:10133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + benzoate + CoA => AMP + benzoyl-CoA + diphosphate
RHEA:24674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cytidine = ADP + CMP + H(+)
REACT:R-HSA-5205822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-18 (H3R17) of histone H3 (Homo sapiens)
REACT:R-MMU-8876283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Mus musculus)
RHEA:28808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + H2O => L-cysteinylglycine + L-glutamate
RHEA:44915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (3E)-hexenoyl-CoA + NADP(+)
RHEA:49608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH
REACT:R-PFA-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Plasmodium falciparum)
RHEA:32235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate
REACT:R-XTR-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Xenopus tropicalis)
REACT:R-XTR-8852317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GTSE1 (Xenopus tropicalis)
REACT:R-SCE-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Saccharomyces cerevisiae)
REACT:R-RNO-4615905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO1 (Rattus norvegicus)
REACT:R-SSC-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Sus scrofa)
RHEA:33210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-glutamate + NADPH <=> ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP S-acetyltransferase activity
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[acyl-carrier-protein] S-acetyltransferase activity
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACPacetyltransferase activity
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACP acetyltransferase activity
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-carrier-protein S-acetyltransferase activity
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-carrier-protein acetyltransferase activity
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[acyl-carrier protein] S-acetyltransferase activity
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-carrier-proteinacetyltransferase activity
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ACAT activity
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity
GO:0004313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A-acyl-carrier-protein transacylase activity
RHEA:11226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-alanyl-D-alanine + H(+) + phosphate => ATP + 2 D-alanine
RHEA:48049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + H2O => D-galactose + ganglioside GM2 (d18:1(4E))
REACT:R-SSC-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Sus scrofa)
REACT:R-DRE-5654631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PPTN11 (Danio rerio)
REACT:R-HSA-2900747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 HD+PEST domain mutants bind DLL4 (Homo sapiens)
REACT:R-HSA-9685268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 8b binds NLRP3 (Homo sapiens)
REACT:R-HSA-4518585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK mRNA translation controlled by miR-92b (Homo sapiens)
REACT:R-SSC-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Sus scrofa)
RHEA:58969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthaldehyde + H2O + O2 => 1-naphthoate + H(+) + H2O2
RHEA:63406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O => 3,6-dichloropyridine-2,5-diol + FADH2 + O2
REACT:R-RNO-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Rattus norvegicus)
REACT:R-HSA-8961619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
RHEA:27807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + acetyl-CoA => acetate + acetoacetyl-CoA
RHEA:14622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => lanosterol
RHEA:28784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinylglycine => glycine + L-cysteine
RHEA:22645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + protopine + reduced [NADPH--hemoprotein reductase] => 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-1678650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses Heparan sulfate chain(5) (Danio rerio)
REACT:R-GGA-3000434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Gallus gallus)
REACT:R-SSC-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Sus scrofa)
REACT:R-GGA-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Gallus gallus)
REACT:R-DRE-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Danio rerio)
REACT:R-XTR-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Xenopus tropicalis)
RHEA:51372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-hexadecenoyl)-glycine
REACT:R-HSA-186798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binds to PDGF-beta receptors only (Homo sapiens)
RHEA:11732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B = H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]
RHEA:11732	skos:prefLabel	"8-dimethylallylnaringenin 2'-hydroxylase"
RHEA:11732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-dimethylallylnaringenin 2'-hydroxylase"
RHEA:11732	skos:altLabel	"8-DMAN 2'-hydroxylase"
RHEA:29089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + oxaloacetate => (S)-malate + menaquinone-8
REACT:R-HSA-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Homo sapiens)
RHEA:51966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:65128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-BTA-5654614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
REACT:R-RNO-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Rattus norvegicus)
RHEA:47079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)
REACT:R-HSA-2408555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer (Homo sapiens)
REACT:R-XTR-429815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation Of Bloc-1 Complex (Xenopus tropicalis)
RHEA:44602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-AMP + diphosphate => a fatty acid + ATP + H(+)
REACT:R-HSA-9012689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Homo sapiens)
RHEA:32104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + trans-resveratrol => 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine
REACT:R-BTA-3791319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NID1 degradation by MMP19 (Bos taurus)
RHEA:10170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin]
REACT:R-MMU-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Mus musculus)
GO:0050389	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronolactonase activity
GO:0050389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uronolactonase activity
GO:0050389	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucurono-6,2-lactone lactonohydrolase activity
REACT:R-CFA-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Canis familiaris)
RHEA:65953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a quinone + H(+) + NADH => 2 a 1,4-benzosemiquinone + NAD(+)
REACT:R-BTA-9700701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T-type VDCC bind T-type VDCC blockers (Bos taurus)
RHEA:25260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine 6-phosphate <=> N-acetyl-D-mannosamine 6-phosphate
REACT:R-HSA-9702629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sunitinib-resistant FLT3 mutants don't bind sunitinib (Homo sapiens)
REACT:R-DDI-9605609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Dictyostelium discoideum)
GO:0047959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, glycine-cytochrome c
GO:0047959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine dehydrogenase (cytochrome) activity
GO:0047959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine:ferricytochrome-c oxidoreductase (deaminating)
GO:0047959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine-cytochrome c reductase activity
REACT:R-DRE-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Danio rerio)
REACT:R-GGA-5229283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCNs bind lipids (Gallus gallus)
RHEA:72709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose(out) + GMP(in) => GDP-beta-L-fucose(in) + GMP(out)
REACT:R-RNO-981728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to membrane-associated C3b (Rattus norvegicus)
RHEA:57330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein]
REACT:R-SSC-9603420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 promotes SRC autophosphorylation (Sus scrofa)
REACT:R-DRE-1604712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP7 by trypsin (Danio rerio)
REACT:R-DRE-8849878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSD-95 binds NMDA receptor (Danio rerio)
RHEA:25666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = beta-pinene + diphosphate
REACT:R-CFA-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Canis familiaris)
REACT:R-DDI-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)
REACT:R-BTA-70577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Bos taurus)
REACT:R-MTU-9635452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pks5 transforms LFCA adenylate ester to mycocerosyl (Mycobacterium tuberculosis)
RHEA:72569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + propanoate(in) => dehydroepiandrosterone 3-sulfate(in) + propanoate(out)
REACT:R-CFA-9015111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors binds Xa (Canis familiaris)
RHEA:21252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
RHEA:21252	skos:altLabel	"alpha-hydroxyglutarate dehydrogenase"
RHEA:21252	skos:altLabel	"L-alpha-hydroxyglutarate dehydrogenase"
RHEA:21252	skos:altLabel	"hydroxyglutaric dehydrogenase"
RHEA:21252	skos:altLabel	"alpha-hydroxyglutarate oxidoreductase"
RHEA:21252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-2-hydroxyglutarate dehydrogenase"
RHEA:21252	skos:altLabel	"alpha-ketoglutarate reductase"
RHEA:21252	skos:prefLabel	"L-2-hydroxyglutarate dehydrogenase"
REACT:R-GGA-4719423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO3 (Gallus gallus)
REACT:R-RNO-5678315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Rattus norvegicus)
REACT:R-BTA-8951951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds EP300 (Bos taurus)
RHEA:24096	skos:prefLabel	"isoorientin 3'-O-methyltransferase"
RHEA:24096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoorientin 3'-O-methyltransferase"
RHEA:24096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoorientin + S-adenosyl-L-methionine = H(+) + isoscoparin + S-adenosyl-L-homocysteine
RHEA:22616	skos:prefLabel	"sulochrin oxidase [(-)-bisdechlorogeodin-forming]"
RHEA:22616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O
RHEA:22616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulochrin oxidase [(-)-bisdechlorogeodin-forming]"
RHEA:22616	skos:altLabel	"sulochrin oxidase"
RHEA:39213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexacosenoyl-CoA + H2O => (3R)-hydroxyhexacosanoyl-CoA
EC:1.13.11.87	skos:prefLabel	"endo-cleaving rubber dioxygenase"
EC:1.13.11.87	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endo-cleaving rubber dioxygenase"
EC:1.13.11.87	skos:altLabel	"latex clearing protein"
REACT:R-HSA-71324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)
RHEA:70612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]
REACT:R-DME-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Drosophila melanogaster)
REACT:R-DDI-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Dictyostelium discoideum)
RHEA:15970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + H(+) + methylarsonate => glutathione disulfide + H2O + methylarsonous acid
REACT:R-CFA-5690870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Canis familiaris)
RHEA:14845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O
REACT:R-GGA-114307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SMAC (DIABLO) from mitochondria (Gallus gallus)
RHEA:10648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 = 6-hydroxyhexan-6-olide + H2O + NADP(+)
REACT:R-DDI-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Dictyostelium discoideum)
REACT:R-MMU-6798258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTPRF, PTPRS, PTPRD bind LRRC4B (Mus musculus)
REACT:R-MMU-9626832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Mus musculus)
RHEA:44700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + FAD + H(+) = a (2E)-enoyl-CoA + FADH2
REACT:R-BTA-5340124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSN polymer binds CaPO4 (Bos taurus)
REACT:R-GGA-352174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Gallus gallus)
EC:1.21.99.-	skos:prefLabel	"With other acceptors"
EC:1.21.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
REACT:R-BTA-2468041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Bos taurus)
REACT:R-GGA-2684507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2, 4, (3) bind FGF2 (Gallus gallus)
REACT:R-RNO-9034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 dimers trans-autophosphorylate (Rattus norvegicus)
REACT:R-SSC-2142859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growing HA is extruded from the cell by ABCC5 (Sus scrofa)
REACT:R-XTR-9701003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 heterodimer (Xenopus tropicalis)
REACT:R-CEL-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Caenorhabditis elegans)
RHEA:31394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) <=> all-trans-4,4'-diapolycopene + 4 FADH2
REACT:R-BTA-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Bos taurus)
RHEA:54378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + nezukol => (+)-copalyl diphosphate + H2O
REACT:R-SSC-6788628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dissociate (Sus scrofa)
RHEA:47565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GA2 (d18:1(4E)) + H(+) + UDP
RHEA:59949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin F2alpha-CoA => CoA + H(+) + prostaglandin F2alpha
REACT:R-GGA-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Gallus gallus)
RHEA:70264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
REACT:R-MMU-4827382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Mus musculus)
RHEA:47595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) <=> CMP + ganglioside GP1c (d18:1(4E)) + H(+)
RHEA:10605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine
REACT:R-PFA-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Plasmodium falciparum)
REACT:R-HSA-8932327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
REACT:R-BTA-3244643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds cyclic GMP-AMP (Bos taurus)
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	terminal transferase activity
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic acid nucleotidyltransferase activity
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxynucleotidyl terminal transferase activity
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	terminal addition enzyme activity
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	terminal deoxyribonucleotidyltransferase activity
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleotidylexotransferase activity
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	addase activity
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TdT
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic nucleotidyltransferase activity
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	terminal deoxynucleotide transferase activity
GO:0003912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	terminal deoxynucleotidyltransferase activity
REACT:R-CFA-159795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Canis familiaris)
REACT:R-BTA-9603982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeA to form LeB (Bos taurus)
REACT:R-BTA-158781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Bos taurus)
RHEA:69312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = benzyl thiocyanate + sulfate
REACT:R-DRE-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Danio rerio)
RHEA:39488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O
GO:0070819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-dependent protoporphyrinogen oxidase activity
GO:0070819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoporphyrinogen-IX:menaquinone oxidoreductase activity
REACT:R-MMU-3209159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERF translocates to the cytosol (Mus musculus)
REACT:R-DRE-400071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Danio rerio)
RHEA:23070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA
REACT:R-HSA-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)
RHEA:43399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)
REACT:R-CFA-5649658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves DHU from damaged DNA (Canis familiaris)
REACT:R-SSC-6785181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 bind LIPC dimer (Sus scrofa)
REACT:R-MMU-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)
GO:0106379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-(d)RTP hydrolase activity
REACT:R-MMU-8985153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OASL binds DDX58 (Mus musculus)
REACT:R-RNO-8942302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP13 cleaves OPTC (Rattus norvegicus)
RHEA:22856	skos:prefLabel	"salutaridinol 7-O-acetyltransferase"
RHEA:22856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salutaridinol 7-O-acetyltransferase"
RHEA:22856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA
REACT:R-HSA-8937864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds tyrosine phosphorylated YAP1 (Homo sapiens)
GO:0034870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pinacolone 5-monooxygenase activity
GO:0050681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear androgen receptor binding
GO:0050681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binding
GO:0050681	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	androgen receptor binding
RHEA:54202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine
RHEA:13522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate
RHEA:64609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UTP => diphosphate + uridylyl-L-threonyl-[protein]
RHEA:56698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tryptophan
REACT:R-BTA-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Bos taurus)
RHEA:47605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) => CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)
GO:0044508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucagon-like peptide 1 receptor activity
RHEA:41854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octanoyl-[ACP]
REACT:R-CFA-1855171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)
REACT:R-RNO-400677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rnd1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)
GO:0050102	skos:prefLabel	"cellodextrin phosphorylase"
GO:0050102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity
GO:0050102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n) + phosphate = [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
GO:0050102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellodextrin phosphorylase"
GO:0050102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellodextrin phosphorylase activity
GO:0050102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity
REACT:R-RNO-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Rattus norvegicus)
REACT:R-CFA-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Canis familiaris)
RHEA:12732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutein <=> (3R,3'S)-zeaxanthin
REACT:R-DRE-8851679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR183 binds 7alpha,25-dihydroxycholesterol (Danio rerio)
RHEA:12785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alditol + NAD(+) = an aldose + H(+) + NADH
REACT:R-CFA-6800315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 binds MST1R (Canis familiaris)
REACT:R-DME-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Drosophila melanogaster)
RHEA:33246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-209925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIT and MIT combine to form triiodothyronine (Homo sapiens)
REACT:R-RNO-1237045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Rattus norvegicus)
RHEA:33050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]
REACT:R-XTR-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Xenopus tropicalis)
RHEA:37430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
RHEA:46622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol
REACT:R-DME-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
REACT:R-BTA-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Bos taurus)
REACT:R-GGA-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Gallus gallus)
REACT:R-MMU-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Mus musculus)
REACT:R-DME-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)
RHEA:49398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-RNO-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
RHEA:10329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-glycol + NAD(+) => a 2-hydroxycarbonyl + H(+) + NADH
REACT:R-MMU-1022129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)
REACT:R-HSA-2730892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV to p-SLP-76 (Homo sapiens)
RHEA:16894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridine + S-adenosyl-L-methionine => N-methylpyridinium + S-adenosyl-L-homocysteine
REACT:R-CFA-201717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK2-mediated phosphorylation of DVL (Canis familiaris)
REACT:R-XTR-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Xenopus tropicalis)
RHEA:72508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + prostaglandin F2alpha(out) => 2-oxoglutarate(out) + prostaglandin F2alpha(in)
REACT:R-DRE-6806629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tonofilament bundles (Danio rerio)
REACT:R-SSC-5634103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 dissociates from atRA:RAR:RXR (Sus scrofa)
RHEA:58576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate + NADP(+) = H(+) + NADPH + precondylocarpine acetate
RHEA:12298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + secologanin => deacetylipecoside + H2O
REACT:R-HSA-5694442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH2,3 bind GRIA1 (Homo sapiens)
REACT:R-RNO-213407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from SLP-76 (Rattus norvegicus)
RHEA:57675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] <=> 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6800315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 binds MST1R (Homo sapiens)
RHEA:49303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]
RHEA:12657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA
RHEA:12657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-methylacyl-CoA racemase"
RHEA:12657	skos:prefLabel	"alpha-methylacyl-CoA racemase"
REACT:R-RNO-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Rattus norvegicus)
REACT:R-CEL-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Caenorhabditis elegans)
REACT:R-HSA-9032067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2 activates RAS signaling through FRS2 (Homo sapiens)
REACT:R-BTA-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Bos taurus)
RHEA:49153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine
RHEA:25000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-phenylalanine = (E)-phenylacetaldehyde oxime + CO2 + H2O
REACT:R-HSA-1678923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR folding by chaperones GP96 and CNPY3 (Homo sapiens)
REACT:R-XTR-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Xenopus tropicalis)
REACT:R-GGA-177936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Gallus gallus)
GO:0016419	skos:altLabel	"malonyl transferase"
GO:0016419	skos:altLabel	"malonyl-CoA/dephospho-CoA acyltransferase"
GO:0016419	skos:altLabel	"malonyl-CoA-acyl carrier protein transacylase"
GO:0016419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[acyl-carrier-protein] S-malonyltransferase"
GO:0016419	skos:altLabel	"acyl carrier protein malonyltransferase"
GO:0016419	skos:altLabel	"malonyl coenzyme A-acyl carrier protein transacylase"
GO:0016419	skos:prefLabel	"[acyl-carrier-protein] S-malonyltransferase"
GO:0016419	skos:altLabel	"MCAT"
GO:0016419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]
GO:0016419	skos:altLabel	"malonyl transacylase"
GO:0016419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-malonyltransferase activity
REACT:R-GGA-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Gallus gallus)
GO:0031866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostanoid EP3 receptor binding
GO:0031866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP3 subtype prostaglandin E2 receptor binding
GO:0031866	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	EP3 subtype prostaglandin E2 receptor ligand
RHEA:55570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine
RHEA:29909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-rac-glycerol)
EC:1.3.98.-	skos:prefLabel	"With other, known, acceptors"
EC:1.3.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
RHEA:39392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)
RHEA:54424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide
RHEA:36173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+) => a 1-acylglycerone 3-phosphate + a long chain fatty alcohol
GO:0047717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazoleacetic hydroxylase activity
GO:0047717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazoleacetate hydroxylase activity
GO:0047717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazoleacetic monooxygenase activity
GO:0047717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazoleacetate 4-monooxygenase activity
GO:0047717	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)
RHEA:49668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NAD(+)
RHEA:38610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-phospho-cyclic ADP-ribose + nicotinate <=> nicotinate-adenine dinucleotide phosphate
REACT:R-MMU-5368586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKK promotes clathrin-dependent internalization of LRP6 (Mus musculus)
REACT:R-XTR-8987150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Xenopus tropicalis)
REACT:R-CFA-5362427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds GPC5 (Canis familiaris)
REACT:R-GGA-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Gallus gallus)
RHEA:46037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + UTP => dCMP + H(+) + UDP
RHEA:11237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + spermidine => propane-1,3-diamine + sym-homospermidine
REACT:R-DRE-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Danio rerio)
REACT:R-HSA-9694633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS virus buds into ERGIC lumen (Homo sapiens)
RHEA:61292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH
RHEA:59159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]
RHEA:69560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(out) + H(+)(out) = D-mannose(in) + H(+)(in)
RHEA:28352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-beta-L-arabinopyranose => UDP-beta-L-arabinofuranose
EC:3.1.1.53	skos:prefLabel	"sialate O-acetylesterase"
EC:3.1.1.53	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sialate O-acetylesterase"
RHEA:21571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O <=> beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose
REACT:R-DDI-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Dictyostelium discoideum)
REACT:R-RNO-9617067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Rattus norvegicus)
REACT:R-BTA-2396029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-3 binds integrins (Bos taurus)
GO:0034946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-isopropylbut-3-enoyl-CoA thioesterase activity
REACT:R-CEL-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:56573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose => globoside Gb3Cer + H(+) + UDP
REACT:R-MMU-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Mus musculus)
REACT:R-RNO-4551649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO1 (Rattus norvegicus)
REACT:R-CFA-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Canis familiaris)
RHEA:47146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:53679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
RHEA:24609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate + H(+) => 2,5-dioxopentanoate + CO2 + H2O
RHEA:20228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + S-adenosyl-L-methionine <=> (E)-ferulate + H(+) + S-adenosyl-L-homocysteine
RHEA:54555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate
RHEA:34299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate
RHEA:34299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-deamino-2'-hydroxyneamine transaminase"
RHEA:34299	skos:prefLabel	"2'-deamino-2'-hydroxyneamine transaminase"
REACT:R-SCE-156808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Saccharomyces cerevisiae)
REACT:R-CEL-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Caenorhabditis elegans)
REACT:R-CEL-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:24102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diisopropyl phosphate + fluoride + 2 H(+) => diisopropyl fluorophosphate + H2O
REACT:R-DRE-349637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spherical HDL and SR-BI receptor form a complex at the cell surface (Danio rerio)
REACT:R-CEL-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Caenorhabditis elegans)
REACT:R-GGA-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Gallus gallus)
RHEA:59022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O
RHEA:53479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-2173781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARCO (SCARA2) binds ligands (Homo sapiens)
REACT:R-CEL-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Caenorhabditis elegans)
REACT:R-MMU-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Mus musculus)
REACT:R-MMU-2395223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyridinoline cross-links (Mus musculus)
REACT:R-BTA-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Bos taurus)
RHEA:19104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-butyne-1,4-diol + NAD(+) <=> 4-hydroxy-2-butynal + H(+) + NADH
RHEA:63634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-[ACP] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[ACP]
REACT:R-DDI-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Dictyostelium discoideum)
REACT:R-HSA-9729330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)
REACT:R-RNO-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Rattus norvegicus)
RHEA:41143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
GO:0047579	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-4-hydroxymandelate oxidase (decarboxylating)
GO:0047579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxymandelate oxidase activity
GO:0047579	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity
REACT:R-MMU-1358795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitination of RNF41 by P-USP8 (Mus musculus)
REACT:R-BTA-75126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Bos taurus)
RHEA:29566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
RHEA:62594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeranial + H(+) + NADPH => (S)-8-oxocitronellyl enol + NADP(+)
REACT:R-DRE-9615249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBs bind AGRT1 (Danio rerio)
REACT:R-MMU-139918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BIM by JNK (Mus musculus)
REACT:R-HSA-434700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 activation of CRAC (Homo sapiens)
RHEA:44178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O
RHEA:18572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + H2O + O2 <=> an aromatic carboxylate + H(+) + H2O2
REACT:R-DME-9633044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR binds STRN (Drosophila melanogaster)
REACT:R-SSC-8949649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Sus scrofa)
REACT:R-HSA-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Homo sapiens)
REACT:R-SCE-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Saccharomyces cerevisiae)
REACT:R-CEL-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Caenorhabditis elegans)
REACT:R-RNO-427645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A3 cotransports Pi, 2Na+ (Rattus norvegicus)
RHEA:30519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoenolpyruvate guanylyltransferase"
RHEA:30519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine
RHEA:30519	skos:prefLabel	"phosphoenolpyruvate guanylyltransferase"
RHEA:49924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-acyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acyl-(R)-carnitine(out)
REACT:R-BTA-6792863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PP2R5C dephosphorylates MDM2 (Bos taurus)
REACT:R-CEL-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
RHEA:29504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => diphosphate + patchoulol
REACT:R-DRE-140599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Danio rerio)
REACT:R-XTR-9023968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Xenopus tropicalis)
REACT:R-SPO-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Schizosaccharomyces pombe)
REACT:R-XTR-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Xenopus tropicalis)
RHEA:38135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
GO:0008493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracyclin transporter activity
GO:0008493	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetracycline transporter activity
GO:0008493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracycline transmembrane transporter activity
REACT:R-HSA-2972975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter (Homo sapiens)
RHEA:65806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine => a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O
RHEA:50928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate
RHEA:42371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-1013020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Gallus gallus)
REACT:R-RNO-9013284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3-ligand complex is cleaved to produce NEXT3 (Rattus norvegicus)
RHEA:44320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-decanoylglycerol + H2O = decanoate + glycerol + H(+)
RHEA:62633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxide + 2 glutathione => an alcohol + glutathione disulfide + H2O
REACT:R-MMU-447252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB1:TYK2 binds IL12RB2:JAK2 (Mus musculus)
RHEA:66762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + kainate(out) + phosphate => ATP + H2O + kainate(in)
REACT:R-DME-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Drosophila melanogaster)
REACT:R-BTA-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Bos taurus)
RHEA:67686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid(out) + ADP + H(+) + phosphate => a long-chain fatty acid(in) + ATP + H2O
REACT:R-SSC-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Sus scrofa)
RHEA:29453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + phosphate => H2O + phosphonate
GO:0034046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(G) binding, within an RNA molecule
GO:0034046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(G) binding
GO:0034046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(rG) binding
GO:0031738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lymphotactin receptor binding
GO:0031738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XCR1 chemokine receptor binding
GO:0031738	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	XCR1 chemokine receptor ligand
REACT:R-CFA-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Canis familiaris)
REACT:R-MMU-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Mus musculus)
REACT:R-HSA-2537665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin-1 and -2 bind fibronectin (Homo sapiens)
REACT:R-GGA-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Gallus gallus)
REACT:R-RNO-450222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Rattus norvegicus)
REACT:R-SSC-5696947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP47 deubiquitinates POLB (Sus scrofa)
RHEA:59638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotriono-1,5-lactone + H2O2 => D-xylotriose + O2
REACT:R-CFA-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Canis familiaris)
REACT:R-CEL-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Caenorhabditis elegans)
REACT:R-DDI-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Dictyostelium discoideum)
RHEA:36555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + sphinganine = CoA + H(+) + N-eicosanoylsphinganine
RHEA:61234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-isoleucine + O2
REACT:R-SSC-1168640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated IkB is degraded (Sus scrofa)
REACT:R-DME-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Drosophila melanogaster)
REACT:R-CFA-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Canis familiaris)
REACT:R-DME-110446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-Chico: Activated DINR binds p60:Dp110 (Drosophila melanogaster)
RHEA:66511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-2045911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
REACT:R-SSC-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Sus scrofa)
REACT:R-CFA-188002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rab5-mediated recruitment of class III PI3K to TLR9 (Canis familiaris)
REACT:R-SCE-5668545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK autophosphorylates on T559 (Saccharomyces cerevisiae)
REACT:R-GGA-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Gallus gallus)
RHEA:26378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP => cyclic pyranopterin phosphate + diphosphate
REACT:R-XTR-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Xenopus tropicalis)
REACT:R-CEL-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Caenorhabditis elegans)
REACT:R-RNO-4084980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Rattus norvegicus)
REACT:R-DME-5690759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Drosophila melanogaster)
REACT:R-DME-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Drosophila melanogaster)
RHEA:26289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate
RHEA:26289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)"
RHEA:26289	skos:altLabel	"cobyrinic acid a,c-diamide synthetase"
RHEA:26289	skos:prefLabel	"cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)"
RHEA:52291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)
REACT:R-CFA-2473584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP15 (Canis familiaris)
RHEA:55498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]
EC:3.4.23.44	skos:prefLabel	"nodavirus endopeptidase"
EC:3.4.23.44	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nodavirus endopeptidase"
EC:3.4.23.44	skos:altLabel	"Flock House virus endopeptidase"
EC:3.4.23.44	skos:altLabel	"Black Beetle virus endopeptidase"
REACT:R-HSA-5690856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Homo sapiens)
RHEA:37792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin A + O2 => aclacinomycin Y + H2O2
REACT:R-HSA-8982165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Homo sapiens)
RHEA:12534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M-coenzyme B heterodisulfide + methane => coenzyme B + methyl-coenzyme M
RHEA:19044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:70470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 <=> a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate
REACT:R-CEL-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Caenorhabditis elegans)
REACT:R-RNO-174757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Rattus norvegicus)
REACT:R-PFA-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Plasmodium falciparum)
RHEA:34791	skos:prefLabel	"2-hydroxyethylphosphonate dioxygenase"
RHEA:34791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyethylphosphonate dioxygenase"
RHEA:34791	skos:altLabel	"HEPD"
RHEA:34791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + O2 = formate + H(+) + hydroxymethylphosphonate
REACT:R-CFA-192341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)
REACT:R-DME-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Drosophila melanogaster)
RHEA:15121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dithioerythritol + thiosulfate = cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite
RHEA:15121	skos:prefLabel	"thiosulfate--dithiol sulfurtransferase"
RHEA:15121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiosulfate--dithiol sulfurtransferase"
RHEA:15121	skos:altLabel	"thiosulfate reductase"
REACT:R-DME-9726949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIR binds PTGIR agonists (Drosophila melanogaster)
RHEA:71635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) + 2 thiosulfate(out) = phosphate(out) + 2 thiosulfate(in)
RHEA:36036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH
RHEA:54073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => beta-thujene + diphosphate
RHEA:50656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O
RHEA:24356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine
RHEA:24356	skos:prefLabel	"lysolecithin acylmutase"
RHEA:24356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysolecithin acylmutase"
RHEA:24356	skos:altLabel	"lysolecithin migratase"
REACT:R-SPO-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Schizosaccharomyces pombe)
REACT:R-CEL-8950522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1:p-STAT4 translocates to the nucleus (Caenorhabditis elegans)
REACT:R-SSC-1980233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Sus scrofa)
REACT:R-HSA-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Homo sapiens)
REACT:R-DDI-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Dictyostelium discoideum)
REACT:R-BTA-5617138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Bos taurus)
REACT:R-DRE-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Danio rerio)
REACT:R-XTR-5654148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR3 (Xenopus tropicalis)
RHEA:33401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out)
REACT:R-BTA-2066781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Bos taurus)
RHEA:34008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrodesmosterol + S-adenosyl-L-methionine => 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine
RHEA:23682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + H(+) + phosphate => a ribonucleoside 5'-triphosphate + H2O
REACT:R-HSA-5676912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methionine is oxidised to methionine sulfoxide (Homo sapiens)
REACT:R-XTR-3244643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds cyclic GMP-AMP (Xenopus tropicalis)
REACT:R-DDI-5649873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Dictyostelium discoideum)
REACT:R-MMU-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Mus musculus)
REACT:R-RNO-9632182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates ESRs (Rattus norvegicus)
REACT:R-CEL-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Caenorhabditis elegans)
GO:0047299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan-phenylpyruvate aminotransferase activity
GO:0047299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan--phenylpyruvate aminotransferase activity
GO:0047299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan-phenylpyruvate transaminase activity
GO:0047299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan--phenylpyruvate transaminase"
GO:0047299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan:phenylpyruvate aminotransferase activity
GO:0047299	skos:altLabel	"tryptophan--phenylpyruvate aminotransferase"
GO:0047299	skos:prefLabel	"tryptophan--phenylpyruvate transaminase"
GO:0047299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan-alpha-ketoisocaproate aminotransferase activity
GO:0047299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-tryptophan = indole-3-pyruvate + L-phenylalanine
REACT:R-BTA-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Bos taurus)
REACT:R-CFA-264865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin A (Canis familiaris)
REACT:R-SSC-9647999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCE1 cleaves S-Farn proRAS proteins (Sus scrofa)
RHEA:21881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + oxalate => 2 CO2 + H2O2
GO:0033283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organic acid-transporting ATPase activity
GO:0033283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent organic acid transmembrane transporter activity
GO:0033283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled organic acid transmembrane transporter activity
RHEA:38397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O
REACT:R-BTA-9638076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from small HA fragments (Bos taurus)
REACT:R-MMU-2029268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of PLCG (Mus musculus)
REACT:R-CFA-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Canis familiaris)
REACT:R-CFA-1474197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP1,3,8,13,PRSS2 (Canis familiaris)
REACT:R-CEL-3204311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)
REACT:R-DRE-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Danio rerio)
REACT:R-CFA-9707977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Canis familiaris)
GO:0140785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid sensing activity
GO:0140785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid sensor activity
REACT:R-HSA-8869558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)
REACT:R-RNO-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Rattus norvegicus)
REACT:R-DDI-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Dictyostelium discoideum)
REACT:R-HSA-2466861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RDH12 does not reduce atRAL to atROL and causes LCA13 (Homo sapiens)
GO:0102058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonoyl-leucine synthetase activity
RHEA:41685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)
REACT:R-BTA-2514831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP14 (Bos taurus)
REACT:R-BTA-6786190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMBL hydrolyses OM to OLMS (Bos taurus)
REACT:R-SSC-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Sus scrofa)
RHEA:71008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + L-tryptophan(in) => L-phenylalanine(in) + L-tryptophan(out)
REACT:R-MMU-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Mus musculus)
RHEA:47539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isochenodeoxycholate + NADP(+)
REACT:R-BTA-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Bos taurus)
RHEA:24056	skos:altLabel	"inositol phosphatase"
RHEA:24056	skos:altLabel	"inositol 1-phosphatase"
RHEA:24056	skos:altLabel	"myo-inositol 1-phosphatase"
RHEA:24056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-phosphate phosphatase"
RHEA:24056	skos:altLabel	"myo-inositol-1-phosphatase"
RHEA:24056	skos:altLabel	"inositol-1(or 4)-monophosphatase"
RHEA:24056	skos:altLabel	"myo-inositol-1(or 4)-monophosphatase"
RHEA:24056	skos:prefLabel	"inositol-phosphate phosphatase"
RHEA:24056	skos:altLabel	"myo-inositol-1(or 4)-phosphate phosphohydrolase"
RHEA:24056	skos:altLabel	"L-myo-inositol-1-phosphate phosphatase"
RHEA:24056	skos:altLabel	"inositol monophosphate phosphatase"
RHEA:24056	skos:altLabel	"myo-inositol monophosphatase"
RHEA:24056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a myo-inositol phosphate + H2O = myo-inositol + phosphate
RHEA:55438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Bos taurus)
RHEA:56300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]
RHEA:63764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine
GO:0047329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoramidic-hexose transphosphorylase activity
GO:0047329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoramidate:hexose 1-phosphotransferase activity
GO:0047329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoramidate-hexose transphosphorylase activity
GO:0047329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoramidate-hexose phosphotransferase activity
REACT:R-MMU-5655466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Mus musculus)
RHEA:48020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose
RHEA:36347	skos:prefLabel	"tRNA 4-demethylwyosine synthase (AdoMet-dependent)"
RHEA:36347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine
RHEA:36347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA 4-demethylwyosine synthase (AdoMet-dependent)"
REACT:R-DME-5678261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Drosophila melanogaster)
EC:3.1.4.39	skos:altLabel	"lysophospholipase D"
EC:3.1.4.39	skos:prefLabel	"alkylglycerophosphoethanolamine phosphodiesterase"
EC:3.1.4.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkylglycerophosphoethanolamine phosphodiesterase"
REACT:R-RNO-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Rattus norvegicus)
RHEA:33990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate <=> diphosphate + neoabietadiene
GO:0036173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate binding
RHEA:44899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP
REACT:R-XTR-5218804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK activation by VEGFR (Xenopus tropicalis)
REACT:R-HSA-1989779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ANKRD1 (Homo sapiens)
RHEA:53594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycerol + phosphate => 1-tetradecanoyl-sn-glycerol 3-phosphate + H2O
RHEA:31985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Sus scrofa)
REACT:R-CFA-5686685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Canis familiaris)
REACT:R-CFA-400677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rnd1 interacts with Plexin-B1:Sema4D (Canis familiaris)
REACT:R-SSC-8852010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL2 binds activated T cells surface (Sus scrofa)
RHEA:23534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + choloyl-CoA + diphosphate => ATP + cholate + CoA
RHEA:61995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
RHEA:48486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic alcohol + H(+) + propanoate => a propanoate ester + H2O
REACT:R-XTR-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Xenopus tropicalis)
REACT:R-BTA-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
REACT:R-SSC-4641260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL1 is degraded by the proteasome (Sus scrofa)
RHEA:17656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
REACT:R-MMU-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Mus musculus)
REACT:R-HSA-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Homo sapiens)
RHEA:41884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:36597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + sulfur => hydrogen sulfide + NADP(+)
RHEA:21089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 => a flavonol + CO2 + H2O + succinate
REACT:R-GGA-9696268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds effectors (Gallus gallus)
REACT:R-RNO-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Rattus norvegicus)
REACT:R-RNO-177939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)
GO:0008996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease G activity
RHEA:17470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]
REACT:R-BTA-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Bos taurus)
RHEA:53634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-(+)-asterisca-2(9),6-diene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-DME-2090085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan chain(1) (Drosophila melanogaster)
REACT:R-RNO-5368596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Rattus norvegicus)
RHEA:19428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + imidazole-4-acetate + NADH + O2 <=> 5-hydroxyimidazole-4-acetate + H2O + NAD(+)
RHEA:47435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-GGA-3928656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves EPHB2 (Gallus gallus)
REACT:R-CFA-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Canis familiaris)
REACT:R-HSA-8851436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFHR dimers bind C3b (Homo sapiens)
REACT:R-DDI-5229111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 transports APP from trans-Golgi network to endosome lumen (Dictyostelium discoideum)
RHEA:29718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate + FMNH2 + O2 <=> FMN + glycolaldehyde + 2 H(+) + H2O + sulfite
RHEA:20632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-[protein] <=> L-seryl-[protein] + phosphate
GO:0034841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mentha-1,3-dione-CoA ligase activity
REACT:R-BTA-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Bos taurus)
REACT:R-CEL-211950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 24-hydroxylates CTL (Caenorhabditis elegans)
REACT:R-HSA-3781001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex (Homo sapiens)
REACT:R-BTA-8849857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates CELA2 (Bos taurus)
REACT:R-SSC-2731078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 2, (4) bind TGFB1 (Sus scrofa)
RHEA:33121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sativene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-CFA-444848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 1 binds relaxin 3 (Canis familiaris)
RHEA:26341	skos:prefLabel	"selenocysteine Se-methyltransferase"
RHEA:26341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"selenocysteine Se-methyltransferase"
RHEA:26341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-selenocysteine + S-methyl-L-methionine = H(+) + L-methionine + Se-methyl-L-selenocysteine
EC:1.99.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Oxygenases"
EC:1.99.2.-	skos:prefLabel	"Oxygenases"
REACT:R-SPO-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Schizosaccharomyces pombe)
REACT:R-RNO-9688831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK3 at K55, K363 (Rattus norvegicus)
GO:0043110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rDNA spacer replication fork barrier binding
GO:0043110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFB binding
REACT:R-XTR-8985594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYO9B inactivates RHOA (Xenopus tropicalis)
REACT:R-RNO-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Rattus norvegicus)
RHEA:72298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate(out) + 3 Na(+)(out) <=> malate(in) + 3 Na(+)(in)
GO:0098634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell-matrix adhesion mediator activity
GO:0098634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein binding involved in cell-matrix adhesion
GO:0098634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell-matrix adhesion molecule
REACT:R-CEL-8849353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Caenorhabditis elegans)
RHEA:56263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose <=> 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP
RHEA:21701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
REACT:R-DRE-378978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Danio rerio)
REACT:R-RNO-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)
GO:0102433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity
REACT:R-DRE-2168079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL (GWL) phosphorylates ARPP19 (Danio rerio)
REACT:R-MMU-6786652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIT1 hydrolyses CHIT to 3xADGP (Mus musculus)
REACT:R-SPO-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)
RHEA:52760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O = (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate
REACT:R-SCE-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Saccharomyces cerevisiae)
REACT:R-XTR-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Xenopus tropicalis)
REACT:R-DRE-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Danio rerio)
REACT:R-HSA-1112602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
GO:0102318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxystreptamine + UDP-alpha-D-glucose = 2'-deamino-2'-hydroxyparomamine + H(+) + UDP
GO:0102318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-deoxystreptamine glucosyltransferase"
GO:0102318	skos:prefLabel	"2-deoxystreptamine glucosyltransferase"
GO:0102318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxystreptamine glucosyltransferase activity
REACT:R-CFA-4085021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Canis familiaris)
REACT:R-BTA-212269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Bos taurus)
RHEA:56702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2
RHEA:64148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)
REACT:R-CFA-9020259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Canis familiaris)
RHEA:37491	skos:prefLabel	"4-coumaroyl-homoserine lactone synthase"
RHEA:37491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-coumaroyl-homoserine lactone synthase"
RHEA:37491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine
RHEA:37491	skos:altLabel	"p-coumaryl-homoserine lactone synthase"
REACT:R-XTR-1170539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor is internalized (Xenopus tropicalis)
RHEA:20446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arogenate + oxaloacetate => L-aspartate + prephenate
RHEA:19673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trihydroxybenzene + O2 = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)
RHEA:19673	skos:prefLabel	"pyrogallol 1,2-oxygenase"
RHEA:19673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrogallol 1,2-oxygenase"
REACT:R-HSA-75028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Wee1 kinase by Chk1 (Homo sapiens)
REACT:R-BTA-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Bos taurus)
REACT:R-XTR-75879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Xenopus tropicalis)
REACT:R-BTA-4570499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Bos taurus)
REACT:R-XTR-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Xenopus tropicalis)
RHEA:71738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + succinate <=> formate + succinyl-CoA
REACT:R-XTR-1006169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds host cell surface markers (Xenopus tropicalis)
RHEA:20612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-arabinonate <=> glycolaldehyde + pyruvate
RHEA:60881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)
REACT:R-XTR-388830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds ICOS (Xenopus tropicalis)
RHEA:62034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O
REACT:R-SSC-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Sus scrofa)
REACT:R-SSC-8855954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Sus scrofa)
REACT:R-SSC-1602398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Sus scrofa)
GO:0047541	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-furoate:CoA ligase (AMP-forming)
GO:0047541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-furoate-CoA ligase activity
GO:0047541	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-furoyl coenzyme A synthetase activity
REACT:R-CFA-4085028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE phosphorylates ManNAc to ManNAc-6-P (Canis familiaris)
EC:3.6.4.6	skos:prefLabel	"vesicle-fusing ATPase"
EC:3.6.4.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vesicle-fusing ATPase"
REACT:R-CEL-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Caenorhabditis elegans)
REACT:R-MMU-211923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26C1 4-hydroxylates 9cRA (Mus musculus)
RHEA:38466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA
REACT:R-BTA-158849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phenol can form a sulfate conjugate (Bos taurus)
REACT:R-BTA-141202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates TYR (Bos taurus)
REACT:R-HSA-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Homo sapiens)
REACT:R-SSC-6810643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPPIN protein complex binds bacteria (Sus scrofa)
RHEA:33272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)
RHEA:17251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 H(+) + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 2 H2O + H2O2
RHEA:48585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin A4
REACT:R-SSC-6804276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TTC5 (Sus scrofa)
REACT:R-CEL-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Caenorhabditis elegans)
REACT:R-HSA-9612534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ID2 and ID4 is repressed by EGR2:NAB (Homo sapiens)
REACT:R-HSA-200410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Homo sapiens)
RHEA:10297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + NADP(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH
RHEA:61791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-tryptophan <=> AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]
RHEA:64748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate
REACT:R-DDI-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Dictyostelium discoideum)
GO:0016778	skos:prefLabel	"Diphosphotransferases"
GO:0016778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Diphosphotransferases"
GO:0016778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphotransferase activity
REACT:R-DRE-5626681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of transition zone proteins (Danio rerio)
RHEA:54387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-5alpha-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH
REACT:R-BTA-9701524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated downstream of active ALK (Bos taurus)
RHEA:34935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate
RHEA:67160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + melleolide F + O2 = 6'-chloromelleolide F + FAD + H(+) + 2 H2O
REACT:R-XTR-2022405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)
RHEA:69094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + pentanoate => H2O + NAD(+) + pentanal
REACT:R-GGA-420584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin 3 trans heterodimer interaction (Gallus gallus)
RHEA:36673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine => (17Z)-hexacosenoyl-CoA + sphinganine
RHEA:41868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:49060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain alkane monooxygenase"
RHEA:49060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain alkane + FMNH2 + O2 = a long chain fatty alcohol + FMN + H(+) + H2O
RHEA:49060	skos:prefLabel	"long-chain alkane monooxygenase"
RHEA:25567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-4-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate
REACT:R-SSC-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Sus scrofa)
REACT:R-SSC-5661120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Sus scrofa)
REACT:R-SCE-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Saccharomyces cerevisiae)
REACT:R-XTR-936897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Xenopus tropicalis)
RHEA:24588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-arabinose = ADP + D-arabinose 5-phosphate + H(+)
RHEA:24588	skos:prefLabel	"D-arabinokinase"
RHEA:24588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arabinokinase"
REACT:R-GGA-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Gallus gallus)
RHEA:23739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyisourate + H2O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)
REACT:R-GGA-8987255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Gallus gallus)
REACT:R-DRE-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)
GO:0050476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylenedicarboxylate hydrase activity
GO:0050476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylenedicarboxylate decarboxylase activity
GO:0050476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylenedicarboxylate hydratase activity
GO:0050476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylenedicarboxylate carboxy-lyase (pyruvate-forming)
GO:0050476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylenedicarboxylate carboxy-lyase activity
REACT:R-SSC-8937419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBR3 reduces DOX to DOXOL (Sus scrofa)
RHEA:36997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA
REACT:R-MMU-141439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of activated MAD2 from kinetochores (Mus musculus)
REACT:R-HSA-8848864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARAP1 (Homo sapiens)
REACT:R-HSA-936475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)
REACT:R-SSC-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Sus scrofa)
REACT:R-SSC-9749986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Sus scrofa)
REACT:R-HSA-140840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
REACT:R-DRE-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)
RHEA:37965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + H(+) + NADH => galactitol + NAD(+)
REACT:R-DRE-8873923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 binds LPCAT1 and PC (Danio rerio)
REACT:R-RNO-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Rattus norvegicus)
REACT:R-SCE-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Saccharomyces cerevisiae)
RHEA:60854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine
RHEA:58898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoyl-CoA + ADP + phosphate => 4-hydroxybutanoate + ATP + CoA
REACT:R-BTA-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Bos taurus)
RHEA:53918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-acyl-L-lysyl-[protein] => an acyl-CoA + L-lysyl-[protein]
RHEA:63915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-azauridine + ATP <=> 6-azauridine 5'-phosphate + ADP + H(+)
REACT:R-SSC-2167942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII ectodomain shedding (Sus scrofa)
REACT:R-DME-1250280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin (Drosophila melanogaster)
REACT:R-RNO-417843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y13 binds ADP (Rattus norvegicus)
RHEA:26491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary nitroalkane + H2O + O2 => a ketone + H(+) + H2O2 + nitrite
RHEA:45383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate
REACT:R-SSC-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Sus scrofa)
RHEA:14779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + NH4(+) => AMP + H(+) + H2O
REACT:R-XTR-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Xenopus tropicalis)
RHEA:16450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + kanamycin B => CoA + H(+) + N(6')-acetylkanamycin B
GO:0033932	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	almond emulsin fucosidase I activity
GO:0033932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-alpha-L-fucosidase activity
GO:0033932	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity
RHEA:49368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) = 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate
REACT:R-HSA-390304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoASH (Homo sapiens)
RHEA:30558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-glutamate + oxidized coenzyme F420-0 <=> GDP + H(+) + oxidized coenzyme F420-1 + phosphate
REACT:R-DME-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Drosophila melanogaster)
RHEA:44013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP]
REACT:R-HSA-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Homo sapiens)
REACT:R-MMU-9021523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWP2 ubiquitinates NOTCH3 (Mus musculus)
REACT:R-MMU-159050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Mus musculus)
REACT:R-RNO-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Rattus norvegicus)
REACT:R-CEL-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Caenorhabditis elegans)
RHEA:69010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrobutanedioate + 4 H2O + 3 NADP(+) => 2 H(+) + L-aspartate + 3 NADPH + 3 O2
REACT:R-CFA-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Canis familiaris)
RHEA:13753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate synthase (NADH)"
RHEA:13753	skos:altLabel	"NADH-dependent glutamate synthase"
RHEA:13753	skos:altLabel	"NADH-glutamate synthase"
RHEA:13753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + L-glutamine + NADH
RHEA:13753	skos:altLabel	"L-glutamate synthetase"
RHEA:13753	skos:altLabel	"L-glutamate synthase"
RHEA:13753	skos:prefLabel	"glutamate synthase (NADH)"
REACT:R-SSC-2130282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated beta catenin by the proteasome (Sus scrofa)
RHEA:49652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protoviolaceinate = H2O + NAD(+) + violaceinate
REACT:R-CFA-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Canis familiaris)
RHEA:17059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP] => a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP]
GO:0016156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate reductase (NADH) activity
GO:0016156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate:NAD+ oxidoreductase activity
GO:0016156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-fumarate reductase activity
GO:0016156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dependent fumarate reductase activity
REACT:R-CEL-212713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLC-gamma1 dissociates from EGFR (Caenorhabditis elegans)
REACT:R-XTR-196026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dab2 is recruited to the junctional plaques (Xenopus tropicalis)
REACT:R-HSA-1358790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates ERBB3 (Homo sapiens)
REACT:R-BTA-2028555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Bos taurus)
REACT:R-RNO-5685366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y-SHC (Rattus norvegicus)
RHEA:36600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + NAD(+) => NADH + sulfur
RHEA:23425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucosamine 1-phosphate => D-glucosamine 6-phosphate
REACT:R-HSA-9629358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to 5-guanidinohydantoin (Homo sapiens)
REACT:R-CEL-5621363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Caenorhabditis elegans)
GO:0080023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Homo sapiens)
GO:0080023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3R-hydroxyacyl-CoA dehydratase activity
RHEA:17272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrocin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tylosin
REACT:R-HSA-75820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta (Homo sapiens)
REACT:R-BTA-450063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Bos taurus)
REACT:R-RNO-8877192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds FOXP3 (Rattus norvegicus)
RHEA:45710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnityl-CoA + acetate => 3-dehydrocarnitine + acetyl-CoA
RHEA:17107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine => malonyl-[ACP] + S-adenosyl-L-methionine
RHEA:58426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hex-2-enal + H(+) + NADPH => (E)-hex-2-en-1-ol + NADP(+)
RHEA:33073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-L-scyllo-inosose + phosphate => D-glucose 6-phosphate
REACT:R-RNO-5690702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN phosphorylates CD22 (Rattus norvegicus)
RHEA:70176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->4)-D-galactose + phosphate => alpha-D-glucose 1-phosphate + D-galactose
REACT:R-DRE-421416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proglucagon translocates from the ER Lumen to secretory granules (Danio rerio)
REACT:R-HSA-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
REACT:R-BTA-913374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits SHIP (Bos taurus)
RHEA:30948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => 10-epi-gamma-eudesmol + diphosphate
REACT:R-DRE-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Danio rerio)
REACT:R-MMU-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)
REACT:R-CFA-111285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)
REACT:R-HSA-1220610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants (Homo sapiens)
RHEA:23982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linear maltodextrin => cyclomaltodextrin + H2O
RHEA:41777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) => CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)
RHEA:46352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + H2O = 3-hydroxydecanoyl-CoA
GO:0050255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribitol 2-dehydrogenase activity
GO:0050255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribitol dehydrogenase D (mutant enzyme with different properties)
GO:0050255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribitol dehydrogenase A (wild type)
GO:0050255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribitol:NAD+ 2-oxidoreductase activity
GO:0050255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adonitol dehydrogenase activity
GO:0050255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribitol dehydrogenase B (mutant enzyme with different properties)
RHEA:17659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + CoA => an acyl-CoA + dihydroxyacetone phosphate
REACT:R-SSC-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Sus scrofa)
RHEA:24843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine
RHEA:56223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP
REACT:R-MMU-2179387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Mus musculus)
REACT:R-RNO-109813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1 binds SOS1 (Rattus norvegicus)
REACT:R-SSC-8952716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 binds Ragulator:Rag dimers (Sus scrofa)
REACT:R-MMU-1295599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 translocates to the plasma membrane (Mus musculus)
REACT:R-CFA-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Canis familiaris)
REACT:R-SSC-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)
RHEA:68110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-L-fructose + NADH => L-glucitol + NAD(+)
REACT:R-SSC-77608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of A1CF to stem-looped RNA (Sus scrofa)
REACT:R-SSC-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Sus scrofa)
RHEA:57385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA
REACT:R-SSC-187688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Sus scrofa)
RHEA:38892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoylsphing-4-enine => hexadecanoate + sphing-4-enine
REACT:R-HSA-9020610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Homo sapiens)
EC:1.3.1.78	skos:altLabel	"arogenic dehydrogenase"
EC:1.3.1.78	skos:altLabel	"TyrAAT2"
EC:1.3.1.78	skos:prefLabel	"arogenate dehydrogenase (NADP(+))"
EC:1.3.1.78	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arogenate dehydrogenase (NADP(+))"
EC:1.3.1.78	skos:altLabel	"TyrAAT1"
EC:1.3.1.78	skos:altLabel	"pretyrosine dehydrogenase"
EC:1.3.1.78	skos:altLabel	"TyrAa"
RHEA:45502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit]
REACT:R-HSA-9625196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unfolded substrate in LAMP2a multimeric complex binds HSPA8 (Homo sapiens)
RHEA:30677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + squalene => tetrahymanol
REACT:R-CEL-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)
REACT:R-HSA-177501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
RHEA:49784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + taurine = CoA + H(+) + taurochenodeoxycholate
REACT:R-HSA-8853755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Homo sapiens)
RHEA:37144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:72762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A6 + malonyl-CoA <=> anthocyanin A8 + CoA
REACT:R-CFA-9728664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1R agonists (Canis familiaris)
REACT:R-GGA-75187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL receptor trimers bind FADD (Gallus gallus)
REACT:R-HSA-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Homo sapiens)
REACT:R-GGA-392054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Gallus gallus)
RHEA:12496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(2+) + 4 H2O + O2 = 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide
RHEA:34918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(in) <=> D-galactose(out)
RHEA:50538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin A2 => prostaglandin E2
REACT:R-SSC-2980720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 binds NEK6/NEK7 in the cytosol (Sus scrofa)
RHEA:72597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in) => H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out)
GO:0043210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkanesulfonate binding
GO:0050009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propan-2-ol = acetone + H(+) + NADPH
GO:0050009	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propan-2-ol:NADP+ oxidoreductase activity
GO:0050009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopropanol dehydrogenase (NADP(+))"
GO:0050009	skos:prefLabel	"isopropanol dehydrogenase (NADP(+))"
GO:0050009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopropanol dehydrogenase (NADP+) activity
EC:3.4.11.26	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"intermediate cleaving peptidase 55"
EC:3.4.11.26	skos:prefLabel	"intermediate cleaving peptidase 55"
REACT:R-BTA-4420128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates SHB (Bos taurus)
RHEA:14669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H2O + NADP(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADPH
REACT:R-MMU-844619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIM2 binds dsDNA (Mus musculus)
REACT:R-MMU-4656914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKBIA with SUMO1 (Mus musculus)
REACT:R-DRE-3769394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CBY1 (Danio rerio)
REACT:R-XTR-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Xenopus tropicalis)
RHEA:47715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-3-hydroxy-L-proline <=> cis-3-hydroxy-D-proline
REACT:R-MMU-381487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP1 binds IGF forming IGF:IGFBP1 (Mus musculus)
REACT:R-CFA-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Canis familiaris)
RHEA:62877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate => A + semiviriditoxin
RHEA:35710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-versicolorone + H(+) + NADPH + O2 <=> (3S)-versiconol acetate + H2O + NADP(+)
REACT:R-SSC-140686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Sus scrofa)
REACT:R-RNO-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Rattus norvegicus)
GO:0015271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	outward rectifier potassium channel activity
REACT:R-DME-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Drosophila melanogaster)
REACT:R-BTA-8868659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
REACT:R-HSA-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Homo sapiens)
RHEA:69920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine(out) + 2 Na(+)(out) => inosine(in) + 2 Na(+)(in)
REACT:R-BTA-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)
REACT:R-MMU-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Mus musculus)
RHEA:69078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) => (R)-noradrenaline + H2O + O2
REACT:R-MMU-9663511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds GSTA1, FABP1 (Mus musculus)
RHEA:33896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose => H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose
RHEA:20913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + taxa-4,11-diene
RHEA:23141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + H2O => D-ribose 5-phosphate + H(+) + nicotinamide
RHEA:39967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobut-2-enoate = 2-iminobutanoate
GO:0016824	skos:prefLabel	"Acting on halide bonds"
GO:0016824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on halide bonds"
GO:0016824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid halide bonds
RHEA:34580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + 2 O2 + pentalenolactone D => 2 CO2 + H2O + pentalenolactone F + 2 succinate
GO:0019902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatase binding
REACT:R-MMU-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Mus musculus)
GO:0102774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-coumaroyltriacetic acid lactone synthase activity
REACT:R-GGA-210289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-DAP12 (Gallus gallus)
RHEA:64951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + H2O <=> dCDP + H(+) + phosphate
REACT:R-BTA-6787737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3R binds CSF3 dimer (Bos taurus)
REACT:R-CFA-1433395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of sSCF (Canis familiaris)
REACT:R-CFA-976768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3b (Canis familiaris)
RHEA:43612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(341) in tmRNA = 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-9009910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds p-S423,S425-SMAD3 (Bos taurus)
REACT:R-CFA-1237325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A is protonated and carbamated causing release of oxygen (Canis familiaris)
REACT:R-HSA-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Homo sapiens)
RHEA:39818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate <=> (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:40356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SSC-193060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)
REACT:R-SCE-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Saccharomyces cerevisiae)
GO:0052597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diamine oxidase activity
GO:0052597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diamine:oxygen oxidoreductase (deaminating) activity
REACT:R-GGA-9647746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 trimerizes (Gallus gallus)
RHEA:36858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-L-cysteine-S-conjugate + H2O <=> acetate + an S-substituted L-cysteine
RHEA:67977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-neurosporene => beta-zeacarotene
REACT:R-PFA-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Plasmodium falciparum)
REACT:R-RNO-165026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Rattus norvegicus)
REACT:R-CFA-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Canis familiaris)
REACT:R-CEL-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Caenorhabditis elegans)
REACT:R-DME-8850992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated PTEN (Drosophila melanogaster)
REACT:R-SCE-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Saccharomyces cerevisiae)
GO:0050275	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:scopoletin glucosyltransferase activity
GO:0050275	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity
GO:0050275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scopoletin glucosyltransferase activity
GO:0050275	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:scopoletin O-beta-D-glucosyltransferase activity
GO:0050275	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SGTase activity
GO:0050275	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-scopoletin glucosyltransferase activity
REACT:R-HSA-6809325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Homo sapiens)
RHEA:42997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => (R)-cembrene A + diphosphate
REACT:R-DME-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Drosophila melanogaster)
REACT:R-DME-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Drosophila melanogaster)
REACT:R-GGA-211191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF with alpha:beta importin (Gallus gallus)
RHEA:63001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienamide + H2O => (11Z,14Z,17Z)-eicosatrienoate + NH4(+)
REACT:R-CFA-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Canis familiaris)
RHEA:60249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]
REACT:R-SCE-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Saccharomyces cerevisiae)
RHEA:36854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA
GO:0008112	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide methyltransferase activity
GO:0008112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide N-methyltransferase activity
GO:0008112	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity
REACT:R-BTA-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Bos taurus)
REACT:R-HSA-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Homo sapiens)
RHEA:29268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine(in) + Na(+)(in) => L-valine(out) + Na(+)(out)
REACT:R-XTR-76354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vinyl chloride is oxidized to 2-Chloroethylene oxide (Xenopus tropicalis)
REACT:R-GGA-8858369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVRL1 binds BMP9,BMP10 (Gallus gallus)
REACT:R-MMU-193763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)
REACT:R-RNO-70355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALK1 phosphorylates Gal to Gal1P (Rattus norvegicus)
REACT:R-CEL-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)
REACT:R-HSA-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Homo sapiens)
RHEA:30560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O => guanosine + H(+) + triphosphate
REACT:R-CEL-8950780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 binds p-Y693-STAT4 (Caenorhabditis elegans)
REACT:R-HSA-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Homo sapiens)
RHEA:46384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0030983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mispair binding
GO:0030983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mispaired DNA binding
GO:0030983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mismatched DNA binding
RHEA:14215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 1-phosphate
REACT:R-RNO-5696490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:CLCF1 binds CNTRF (Rattus norvegicus)
REACT:R-RNO-192178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP39A1 7-hydroxylates 24OH-CHOL (Rattus norvegicus)
RHEA:16891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-acetamido-3-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-acetamido-3-aminohexanoate
RHEA:15087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O
REACT:R-DME-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Drosophila melanogaster)
RHEA:63359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2
REACT:R-BTA-9009065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXA1 and GATA3 bind to CCND1 promoter (Bos taurus)
REACT:R-SSC-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)
RHEA:63900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate + H(+) = (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O
REACT:R-RNO-9606894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DAPP1 (p-BAM32) binds PLCG2 (Rattus norvegicus)
RHEA:66918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate
RHEA:31800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-aminomethyl-2-methylpyrimidine + H2O => 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)
RHEA:32384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-limonene-1,2-diol + NAD(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH
RHEA:67329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione => trichosetin
RHEA:46437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]
RHEA:30400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lovastatin nonaketide synthase activity
GO:0050637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)
REACT:R-HSA-4568863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RAD52 with SUMO1 (Homo sapiens)
REACT:R-CFA-6805470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates TP53 (Canis familiaris)
RHEA:31882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> beta-seco-amyrin
REACT:R-SSC-3222093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 binds TP53 and EP300 (Sus scrofa)
REACT:R-CFA-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
REACT:R-MMU-8932275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Mus musculus)
REACT:R-XTR-5654222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PLCG1 (Xenopus tropicalis)
RHEA:45423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine
GO:0103083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiobutylmalate isomerase activity
REACT:R-MMU-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Mus musculus)
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydropteroate synthase"
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity
GO:0004156	skos:altLabel	"dihydropteroate pyrophosphorylase"
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydropteroate synthetase activity
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydropteroate synthase activity
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydropteroate diphosphorylase activity
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate
GO:0004156	skos:prefLabel	"dihydropteroate synthase"
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydropteroic synthetase activity
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydropteroic acid synthetase activity
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHPS activity
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydropteroate pyrophosphorylase activity
GO:0004156	skos:altLabel	"DHPS"
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydropteroate synthetase activity
GO:0004156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydropteroate synthase activity
GO:0004156	skos:altLabel	"dihydropteroate diphosphorylase"
REACT:R-HSA-9017797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds YBX1 (Homo sapiens)
REACT:R-RNO-8852306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Rattus norvegicus)
REACT:R-XTR-9678737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR1:TYK2 binds TYK2 inhibitors (Xenopus tropicalis)
REACT:R-PFA-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Plasmodium falciparum)
RHEA:48803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)
REACT:R-MMU-5138433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Mus musculus)
RHEA:12277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-CEL-2161959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Caenorhabditis elegans)
REACT:R-CFA-5607750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Canis familiaris)
REACT:R-CFA-8941623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
REACT:R-SCE-68918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK and DDK associate with the Mcm10:pre-replicative complex (Saccharomyces cerevisiae)
GO:0047598	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sterol Delta(7)-reductase activity
GO:0047598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR7 reduces 7-dehydroCHOL to CHOL (Homo sapiens)
GO:0047598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol:NADP+ delta7-oxidoreductase activity
GO:0047598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol delta7-reductase activity
GO:0047598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-DHC reductase activity
GO:0047598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol reductase activity
RHEA:39888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin
RHEA:63564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apelin-13 + H2O = apelin-12 + L-phenylalanine
REACT:R-SSC-171059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Sus scrofa)
REACT:R-RNO-1549564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)
RHEA:38335	skos:prefLabel	"ginsenoside Rb1 beta-glucosidase"
RHEA:38335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ginsenoside Rb1 beta-glucosidase"
RHEA:38335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb1 + 2 H2O = (20S)-ginsenoside Rg3 + 2 D-glucose
GO:0008949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalyl-CoA carboxy-lyase (formyl-CoA-forming)
GO:0008949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalyl coenzyme A decarboxylase activity
GO:0008949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalyl-CoA decarboxylase activity
GO:0008949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalyl-CoA carboxy-lyase activity
REACT:R-XTR-217255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO1:FAD N-oxidises TAM (Xenopus tropicalis)
REACT:R-DME-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Drosophila melanogaster)
RHEA:20069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenylacetaldehyde oxime = H2O + phenylacetonitrile
RHEA:71844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tauroursodeoxycholate(out) => tauroursodeoxycholate(in)
REACT:R-SSC-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Sus scrofa)
RHEA:33596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine
RHEA:45215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) <=> CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]
RHEA:21017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-asparagine => L-aspartate + NH4(+)
GO:0018645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkene,NADH:oxygen oxidoreductase activity
GO:0018645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkene monooxygenase"
GO:0018645	skos:prefLabel	"alkene monooxygenase"
GO:0018645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkene epoxygenase activity
GO:0018645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkene monooxygenase activity
GO:0018645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + propene = 1,2-epoxypropane + H2O + NAD(+)
GO:0018645	skos:altLabel	"alkene epoxygenase"
REACT:R-CFA-9749609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCHE hydrolyzes ASA- (Canis familiaris)
RHEA:68552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase"
RHEA:68552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine = H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
RHEA:68552	skos:prefLabel	"UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase"
RHEA:68552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine = H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
RHEA:49236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein](out) + sucrose = L-histidyl-[protein] + sucrose 6(G)-phosphate(in)
RHEA:49236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--sucrose phosphotransferase"
RHEA:49236	skos:prefLabel	"protein-N(pi)-phosphohistidine--sucrose phosphotransferase"
RHEA:49236	skos:altLabel	"sucrose PTS permease"
REACT:R-HSA-9026001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA (Homo sapiens)
REACT:R-DME-5654159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds PLCG1 (Drosophila melanogaster)
REACT:R-HSA-1237045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Homo sapiens)
REACT:R-SSC-70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)
REACT:R-GGA-9647619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD forms ring‐shaped oligomers  (Gallus gallus)
REACT:R-HSA-9007539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates E2F6 (Homo sapiens)
RHEA:31973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+) => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2
REACT:R-RNO-447130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-23 binds interleukin-23 receptor (Rattus norvegicus)
REACT:R-MMU-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Mus musculus)
GO:0019133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline monooxygenase activity
GO:0019133	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline,reduced-ferredoxin:oxygen oxidoreductase activity
REACT:R-DRE-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Danio rerio)
REACT:R-MMU-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Mus musculus)
REACT:R-CEL-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Caenorhabditis elegans)
GO:0102386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetaldehyde reductase activity
RHEA:53062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate
REACT:R-HSA-193737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Homo sapiens)
RHEA:71598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + succinate(in) <=> 2-oxoglutarate(in) + succinate(out)
RHEA:29048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+)(in) + H2 => a menaquinol + 2 H(+)(out)
REACT:R-SCE-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Saccharomyces cerevisiae)
REACT:R-CFA-6809521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPIF binds bacteria (Canis familiaris)
RHEA:65985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hnu + previtamin D3 => lumisterol 3
REACT:R-BTA-933533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of p-IRF7 (Bos taurus)
REACT:R-DME-6798258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTPRF, PTPRS, PTPRD bind LRRC4B (Drosophila melanogaster)
REACT:R-BTA-9678766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 binds CYP3A4 inhibitors (Bos taurus)
REACT:R-SSC-5691507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPA deacetylates NAA to acetate and L-aspartate (Sus scrofa)
RHEA:55804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O = (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)
GO:0004661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein geranylgeranyltransferase activity
GO:0004661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-cysteine geranylgeranyltransferase activity
REACT:R-SSC-9684068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD binds cardiac glycosides (Sus scrofa)
REACT:R-RNO-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)
RHEA:22720	skos:prefLabel	"protein-histidine pros-kinase"
RHEA:22720	skos:altLabel	"protein histidine kinase"
RHEA:22720	skos:altLabel	"protein kinase (histidine)"
RHEA:22720	skos:altLabel	"histidine protein kinase"
RHEA:22720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-histidine pros-kinase"
RHEA:22720	skos:altLabel	"HK2"
RHEA:22720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidyl-[protein] = ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]
RHEA:22720	skos:altLabel	"histidine kinase"
GO:0033300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroascorbate transporter activity
GO:0033300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroascorbic acid transmembrane transporter activity
GO:0033300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydroascorbic acid transporter activity
RHEA:14777	skos:altLabel	"AMP aminase"
RHEA:14777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + H2O = IMP + NH4(+)
RHEA:14777	skos:altLabel	"AMP aminohydrolase"
RHEA:14777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"AMP deaminase"
RHEA:14777	skos:prefLabel	"AMP deaminase"
RHEA:14777	skos:altLabel	"myoadenylate deaminase"
RHEA:14777	skos:altLabel	"adenylic acid deaminase"
RHEA:14777	skos:altLabel	"adenylate deaminase"
RHEA:14777	skos:altLabel	"5-AMP deaminase"
RHEA:46449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-tyrosyl-tRNA(Tyr) => cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)
REACT:R-BTA-433099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS2 co-transports sulphate and two sodium ions (Bos taurus)
REACT:R-RNO-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Rattus norvegicus)
REACT:R-SSC-5649711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 incises DNA strand 5' to the AP site (Sus scrofa)
REACT:R-RNO-3247493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO1 (Rattus norvegicus)
REACT:R-CFA-5649854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to oxidatively damaged AP site (Canis familiaris)
REACT:R-CFA-977363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3bBb (Canis familiaris)
RHEA:68893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxybenzoate + ATP + H(+) + NADPH => 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)
RHEA:59942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyloctadecanoate + CoA + H(+) => 2-methyloctadecanoyl-CoA + H2O
REACT:R-RNO-9667619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B,2 bind atosiban (Rattus norvegicus)
REACT:R-MMU-8851298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR143 binds L-Dopa (Mus musculus)
RHEA:50870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2
REACT:R-DME-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Drosophila melanogaster)
REACT:R-SSC-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Sus scrofa)
RHEA:71860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate(out) => glycochenodeoxycholate(in)
REACT:R-HSA-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)
RHEA:60564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose + ATP = 2-deoxy-D-glucose 6-phosphate + ADP + H(+)
RHEA:38509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O
REACT:R-SSC-158721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Sus scrofa)
REACT:R-DRE-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Danio rerio)
REACT:R-SPO-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Schizosaccharomyces pombe)
RHEA:64982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:71414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)
RHEA:51071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate <=> (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine
REACT:R-XTR-1236954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides by IRAP in endocytic vesicles (Xenopus tropicalis)
REACT:R-XTR-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Xenopus tropicalis)
RHEA:48986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorophenol + CO2 + glyoxylate + succinate => (2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2
RHEA:15762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH
GO:0099635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
REACT:R-DME-9008285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Drosophila melanogaster)
REACT:R-RNO-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Rattus norvegicus)
REACT:R-CEL-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Caenorhabditis elegans)
REACT:R-MMU-8940074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NMN (Mus musculus)
RHEA:45486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + CO2 => H(+) + pyruvate
REACT:R-DRE-174441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Danio rerio)
REACT:R-HSA-189398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
RHEA:26122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:25349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tyrosine + tRNA(Tyr) => D-tyrosyl-tRNA(Tyr) + H2O
RHEA:70522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-octopamine + S-adenosyl-L-methionine <=> (R)-synephrine + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-141348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAO:FAD oxidises NASPM to PTCN (Mus musculus)
REACT:R-CFA-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Canis familiaris)
REACT:R-SSC-937034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino (Sus scrofa)
REACT:R-DRE-5683425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53BP1 at DNA DSBs (Danio rerio)
REACT:R-MMU-2022396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-43) (Mus musculus)
REACT:R-BTA-2161899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)
REACT:R-CFA-1112514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK activation (Canis familiaris)
RHEA:55765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O => 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
REACT:R-DRE-2002460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB binds Collagen chains (Danio rerio)
RHEA:46525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-216058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Mus musculus)
REACT:R-GGA-265940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rad51 assembly at the DNA-damage sites on the chromatin (Gallus gallus)
REACT:R-MMU-449058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family are secreted (Mus musculus)
REACT:R-MMU-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Mus musculus)
REACT:R-DME-8956099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Drosophila melanogaster)
RHEA:50229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 + resorcinol => benzene-1,2,4-triol + FAD + H(+) + H2O
REACT:R-XTR-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Xenopus tropicalis)
RHEA:49637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylglyoxal + O2 => H(+) + H2O2 + pyruvate
RHEA:53201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
REACT:R-HSA-3244605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREX1 binds retroviral-derived DNA (Homo sapiens)
REACT:R-HSA-452701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DPPA4 (Homo sapiens)
REACT:R-MMU-8850794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK5 (Mus musculus)
REACT:R-DRE-109699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
RHEA:44365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone + ATP => 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)
REACT:R-MMU-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Mus musculus)
REACT:R-HSA-392530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S400-Cot phosphorylates NIK (Homo sapiens)
REACT:R-BTA-1168635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (PKC-beta) phosphorylates CARMA1 (Bos taurus)
RHEA:61201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
RHEA:20182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose derivative + UDP-alpha-D-glucose => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP
REACT:R-GGA-9670673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIX is secreted (Gallus gallus)
RHEA:56848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-didemethyltoxoflavin + S-adenosyl-L-methionine = H(+) + reumycin + S-adenosyl-L-homocysteine
REACT:R-MMU-350604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Agmatine + H2O <=> putrescine + urea (Mus musculus)
RHEA:71184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine(out) + L-tryptophan(in) => L-kynurenine(in) + L-tryptophan(out)
RHEA:63288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diiodothyronine 5'-deiodinase activity
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyroxine 5' deiodinase activity
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type II iodothyronine deiodinase activity
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	outer ring-deiodinating pathway
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	thyroxine deiodinase activity
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-thyroxine iodohydrolase (reducing) activity
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iodothyronine 5'-deiodinase activity
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iodothyronine outer ring monodeiodinase activity
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyroxine 5'-deiodinase activity
GO:0004800	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type I iodothyronine deiodinase activity
RHEA:25482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + succinate => acetoacetate + succinyl-CoA
REACT:R-GGA-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Gallus gallus)
REACT:R-XTR-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Xenopus tropicalis)
RHEA:44367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone + ATP <=> 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)
REACT:R-SSC-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Sus scrofa)
RHEA:42014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH => cortisol + NAD(+)
RHEA:34884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + selenate(out) => ADP + H(+) + phosphate + selenate(in)
RHEA:70048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + L-kynurenine => H2O + kynurenate + L-2-aminoadipate
REACT:R-BTA-9687625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds MLKL (Bos taurus)
REACT:R-DDI-372480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Dictyostelium discoideum)
REACT:R-BTA-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Bos taurus)
EC:1.11.1.14	skos:prefLabel	"lignin peroxidase"
EC:1.11.1.14	skos:altLabel	"diarylpropane oxygenase"
EC:1.11.1.14	skos:altLabel	"LiP"
EC:1.11.1.14	skos:altLabel	"diarylpropane peroxidase"
EC:1.11.1.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lignin peroxidase"
EC:1.11.1.14	skos:altLabel	"ligninase I"
REACT:R-XTR-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Xenopus tropicalis)
RHEA:47847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate
REACT:R-DME-8876484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 transfers CHOL to NPC1 (Drosophila melanogaster)
REACT:R-HSA-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Homo sapiens)
REACT:R-CFA-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Canis familiaris)
RHEA:22117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP
REACT:R-GGA-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)
REACT:R-SSC-193099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPROG to ANDST (Sus scrofa)
RHEA:23424	skos:prefLabel	"phosphoglucosamine mutase"
RHEA:23424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglucosamine mutase"
RHEA:23424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate
RHEA:38035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate = (4Z)-2-oxohept-4-enedioate
REACT:R-BTA-3791149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Bos taurus)
RHEA:14911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucuronate + H(+) + NADPH => L-gulonate + NADP(+)
RHEA:63190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + norbelladine => 3,4-dihydroxybenzaldehyde + AH2 + tyramine
RHEA:41765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) => CMP + ganglioside GT3 (d18:1(4E)) + H(+)
RHEA:31240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + uroporphyrinogen I => 4 CO2 + coproporphyrinogen I
RHEA:10689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + streptomycin 6-phosphate => phosphate + streptomycin
RHEA:72082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + selenate(out) <=> 3 Na(+)(in) + selenate(in)
REACT:R-MMU-5649723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Mus musculus)
RHEA:49493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O
RHEA:24470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N-dimethylaniline N-oxide + NADP(+) => H(+) + N,N-dimethylaniline + NADPH + O2
RHEA:43925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pregnenolone => H(+) + NADH + pregn-5-ene-3,20-dione
GO:0102454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-galactosyltransferase activity
REACT:R-DME-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Drosophila melanogaster)
REACT:R-SCE-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Saccharomyces cerevisiae)
REACT:R-XTR-879910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 is phosphorylated, activated (Xenopus tropicalis)
RHEA:16616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an arylamine <=> an N-acetylarylamine + CoA
REACT:R-RNO-2029452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to phosphorylated ITAMs (Rattus norvegicus)
REACT:R-HSA-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Homo sapiens)
REACT:R-HSA-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Homo sapiens)
REACT:R-DME-9646348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Drosophila melanogaster)
RHEA:28550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + anthranilate = CoA + N-acetylanthranilate
REACT:R-HSA-1791137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Talin-1 (Homo sapiens)
GO:0061929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-glutamylaminecyclotransferase activity
RHEA:29850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA <=> (3Z)-tetradecenoyl-CoA
REACT:R-CFA-8983845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dissociates from IL6ST:IL6ST (Canis familiaris)
RHEA:50561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]
REACT:R-RNO-168405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD oligomer recruites RIP2 (RICK) (Rattus norvegicus)
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4-diaminobutyrate 4-aminotransferase activity
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diaminibutyric acid aminotransferase activity
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diaminobutyrate--2-oxoglutarate aminotransferase activity
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diaminobutyrate transaminase activity
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DABA aminotransferase activity
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	EctB
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAB aminotransferase activity
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diaminobutyrate-2-oxoglutarate transaminase activity
GO:0045303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity
RHEA:27673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1-phosphate + H2O <=> myo-inositol + phosphate
REACT:R-MMU-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)
REACT:R-DME-204824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Ang4 (Drosophila melanogaster)
REACT:R-GGA-353426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG glycosylase mediated recognition and binding of thymine opposite guanine (Gallus gallus)
REACT:R-RNO-6791218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)
RHEA:22042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + L-aspartate => H2O + N-formyl-L-aspartate
REACT:R-MMU-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Mus musculus)
REACT:R-GGA-5688837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 deubiquitinates polyUb-PARK2 (Gallus gallus)
REACT:R-PFA-8959462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Plasmodium falciparum)
REACT:R-BTA-5659781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 forms a heterodimer with BARD1 (Bos taurus)
REACT:R-HSA-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Homo sapiens)
REACT:R-BTA-190065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TrkA receptor internalizes to endosomes (Bos taurus)
RHEA:19354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate + H2O => cholate + glycine
RHEA:52582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + Pb(2+)(out) + phosphate => ATP + H2O + Pb(2+)(in)
REACT:R-SSC-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Sus scrofa)
EC:2.3.3.3	skos:altLabel	"(R)-citrate synthase"
EC:2.3.3.3	skos:altLabel	"Re-citrate-synthase"
EC:2.3.3.3	skos:prefLabel	"citrate (Re)-synthase"
EC:2.3.3.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citrate (Re)-synthase"
EC:2.3.3.3	skos:altLabel	"citrate oxaloacetate-lyase [(pro-3R)-CH2COO(-)->acetyl-CoA]"
REACT:R-SSC-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Sus scrofa)
RHEA:60403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine
REACT:R-XTR-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)
RHEA:33579	skos:prefLabel	"UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase"
RHEA:33579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate = H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
RHEA:33579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase"
RHEA:36391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + NADP(+) = desmosterol + H(+) + NADPH
RHEA:12739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[PrdC protein]-L-selenocysteine/L-cysteine + D-proline => 5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine
RHEA:20189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + NAD(+) = H(+) + NADH + uracil
REACT:R-RNO-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-HSA-5696183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC3 deaminates BZAM (Homo sapiens)
REACT:R-HSA-9636684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP (Homo sapiens)
GO:0018846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SOI activity
GO:0018846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	styrene oxide isomerase activity
GO:0018846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	styrene-oxide isomerase (epoxide-cleaving)
GO:0018846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	styrene-oxide isomerase activity
RHEA:10215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 5-aminopentanoate <=> 5-oxopentanoate + L-glutamate
REACT:R-BTA-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Bos taurus)
REACT:R-HSA-193684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 recruits an atypical PKC (Homo sapiens)
RHEA:24885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) <=> H(+) + L-glutamate + NADPH
REACT:R-XTR-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Xenopus tropicalis)
RHEA:50192	skos:altLabel	"UDP-xylose-core protein beta-D-xylosyltransferase"
RHEA:50192	skos:altLabel	"uridine diphosphoxylose-protein xylosyltransferase"
RHEA:50192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein xylosyltransferase"
RHEA:50192	skos:altLabel	"uridine diphosphoxylose-core protein beta-xylosyltransferase"
RHEA:50192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP
RHEA:50192	skos:prefLabel	"protein xylosyltransferase"
REACT:R-HSA-2161745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)
REACT:R-GGA-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Gallus gallus)
REACT:R-HSA-210767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification (Homo sapiens)
REACT:R-XTR-192123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates CHOL (Xenopus tropicalis)
RHEA:68177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-geranyl-L-glutamate + O2 => CO2 + dainate A + H2O + succinate
REACT:R-HSA-9023633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
REACT:R-DDI-8959510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)
RHEA:45874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA => 15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17-O-deacetylvindoline-17-O-acetyltransferase activity
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAT activity
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-O-deacetylvindoline O-acetyltransferase activity
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetylvindoline O-acetyltransferase activity
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity
GO:0047162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetylvindoline acetyltransferase activity
RHEA:57167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate
REACT:R-BTA-688136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)
RHEA:51898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + spermine => H2O + N(1)-acetylspermine
RHEA:44898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose
REACT:R-DDI-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Dictyostelium discoideum)
REACT:R-HSA-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Homo sapiens)
REACT:R-MMU-1362485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GH (Mus musculus)
GO:0050130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-2-oxoglutaramate hydrolase activity
GO:0050130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-hydroxy-N-methylpyroglutamate synthase activity
GO:0050130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methyl-2-oxoglutaramate methylamidohydrolase activity
REACT:R-BTA-6811508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2-bound EP300 acetylates TP53 (Bos taurus)
RHEA:20833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanine(out) + H2O => ADP + guanine(in) + H(+) + phosphate
RHEA:68363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylono-1,4-lactone + O2 <=> dehydro-L-arabinono-1,4-lactone + H(+) + H2O2
REACT:R-CEL-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Caenorhabditis elegans)
REACT:R-RNO-2396029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-3 binds integrins (Rattus norvegicus)
RHEA:28285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-bisabolene <=> (S)-beta-macrocarpene
REACT:R-MMU-5624133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3:GTP binds the UNC119B complex (Mus musculus)
RHEA:44103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + octanal <=> 2 H(+) + NADH + octanoate
REACT:R-BTA-9718379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds chemical antagonists (Bos taurus)
REACT:R-GGA-167427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid dissociates from MOR (Gallus gallus)
REACT:R-CFA-5422942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXRA:PPARD binds FABP5:atRA (Canis familiaris)
REACT:R-DME-5654692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
REACT:R-MMU-9027607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Mus musculus)
REACT:R-MMU-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Mus musculus)
RHEA:22981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] => a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]
GO:0050570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase activity
GO:0050570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine 4-phosphate dehydrogenase activity
GO:0050570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(phosphohydroxy)-L-threonine dehydrogenase activity
GO:0050570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+-dependent threonine 4-phosphate dehydrogenase activity
GO:0050570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PdxA
GO:0050570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxythreonine-4-phosphate dehydrogenase activity
GO:0050570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(+)-dependent threonine 4-phosphate dehydrogenase activity
EC:1.14.20.14	skos:prefLabel	"hapalindole-type alkaloid chlorinase"
EC:1.14.20.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hapalindole-type alkaloid chlorinase"
REACT:R-HSA-4570573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RFT1 does not flip the N-glycan precursor (Homo sapiens)
RHEA:17078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N-dimethylglycine + O2 => formaldehyde + H2O2 + sarcosine
REACT:R-PFA-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Plasmodium falciparum)
REACT:R-DRE-1855208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Danio rerio)
REACT:R-DME-1470010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs (Drosophila melanogaster)
REACT:R-MMU-688137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 is K63 polyubiquitinated (Mus musculus)
RHEA:49046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyprotoasukamycin + H2O + NAD(+) => H(+) + NADH + O2 + protoasukamycin
REACT:R-HSA-9009558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds SDC1 (Homo sapiens)
REACT:R-DRE-114544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p115-RhoGEF activation of RHOA (Danio rerio)
REACT:R-DRE-140978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex binds FADD (Danio rerio)
RHEA:21360	skos:altLabel	"NAD(+) diphosphorylase"
RHEA:21360	skos:prefLabel	"nicotinamide-nucleotide adenylyltransferase"
RHEA:21360	skos:altLabel	"nicotinamide mononucleotide adenylyltransferase"
RHEA:21360	skos:altLabel	"adenosine triphosphate-nicotinamide mononucleotide transadenylase"
RHEA:21360	skos:altLabel	"NAD(+) pyrophosphorylase"
RHEA:21360	skos:altLabel	"NMNAT"
RHEA:21360	skos:altLabel	"NMN adenylyltransferase"
RHEA:21360	skos:altLabel	"diphosphopyridine nucleotide pyrophosphorylase"
RHEA:21360	skos:altLabel	"nicotinamide adenine dinucleotide pyrophosphorylase"
RHEA:21360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinamide-nucleotide adenylyltransferase"
RHEA:21360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)
GO:0032183	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Smt3 monomer binding
GO:0032183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO binding
GO:0032183	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Smt3 binding
REACT:R-DDI-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Dictyostelium discoideum)
GO:1902670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon dioxide binding
GO:1902670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 binding
RHEA:11460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+)
REACT:R-SSC-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Sus scrofa)
REACT:R-BTA-77592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Intronless Pre-mRNA at 3'-end (Bos taurus)
RHEA:12588	skos:altLabel	"ganglioside GM3 acetylgalactosaminyltransferase"
RHEA:12588	skos:altLabel	"UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase"
RHEA:12588	skos:altLabel	"uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase"
RHEA:12588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase"
RHEA:12588	skos:altLabel	"beta-1,4N-aetylgalactosaminyltransferase"
RHEA:12588	skos:altLabel	"GM2 synthase"
RHEA:12588	skos:altLabel	"ganglioside GM2 synthase"
RHEA:12588	skos:altLabel	"uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase"
RHEA:12588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 (d18:1(4E)) + H(+) + UDP
RHEA:12588	skos:altLabel	"uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase"
RHEA:12588	skos:altLabel	"asialo-GM2 synthase"
RHEA:12588	skos:prefLabel	"(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase"
RHEA:12588	skos:altLabel	"UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase"
RHEA:12588	skos:altLabel	"GalNAc-T"
RHEA:12588	skos:altLabel	"GM2/GD2-synthase"
REACT:R-DRE-4085087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Danio rerio)
GO:0015655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:alanine symporter activity
GO:0015655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine:sodium symporter activity
GO:0015655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out)
REACT:R-MMU-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Mus musculus)
REACT:R-SSC-193961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Sus scrofa)
RHEA:29949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-rhamnopyranose(out) => H(+)(in) + L-rhamnopyranose(in)
REACT:R-GGA-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Gallus gallus)
RHEA:36178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)
REACT:R-DRE-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Danio rerio)
REACT:R-SSC-217255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO1:FAD N-oxidises TAM (Sus scrofa)
REACT:R-SSC-8940100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates VCPIP1 (Sus scrofa)
GO:0008301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA binding, bending
GO:0008301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA bending involving DNA binding
GO:0008301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA bending activity
RHEA:33707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-threonine kinase"
RHEA:33707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonine = ADP + H(+) + O-phospho-L-threonine
RHEA:33707	skos:prefLabel	"L-threonine kinase"
REACT:R-HSA-3296301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCRL2 binds CCL19 (Homo sapiens)
REACT:R-SCE-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Saccharomyces cerevisiae)
REACT:R-DRE-210430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of L-Glutamate at the synapse (Danio rerio)
REACT:R-SSC-174251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Sus scrofa)
GO:0051265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioleoylglycerol transacylase activity
GO:0051265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOG transacylation
GO:0051265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA-independent diolein transacylation
GO:0051265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioleoylglycerol O-acyltransferase activity
GO:0051265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diolein transacylation activity
REACT:R-MMU-73718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBF-1 Binds rDNA Promoter (Mus musculus)
RHEA:39474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)
REACT:R-DRE-8944216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XV (Danio rerio)
REACT:R-DME-8942101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 monoubiquitinates Histone H2B (Drosophila melanogaster)
GO:0004741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate dehydrogenase phosphatase activity
GO:0004741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity
GO:0004741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate dehydrogenase (lipoamide) phosphatase activity
GO:0004741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0004741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate dehydrogenase (lipoamide)-phosphatase activity
GO:0004741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity
GO:0004741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate dehydrogenase phosphatase activity
REACT:R-DRE-162742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Danio rerio)
REACT:R-SSC-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Sus scrofa)
REACT:R-MMU-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Mus musculus)
RHEA:32578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (1R,5R)-alpha-pinene + diphosphate
REACT:R-GGA-4420107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHC-transforming protein 2 (Gallus gallus)
REACT:R-BTA-6786720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DECR2 reduces LCtE-CoA to t3enoyl-CoA (Bos taurus)
REACT:R-GGA-8853792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET tyrosine phosphorylation (Gallus gallus)
REACT:R-HSA-192010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)
RHEA:15548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalate <=> acetate + pyruvate
REACT:R-SCE-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Saccharomyces cerevisiae)
RHEA:64249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + glycine => CoA + H(+) + N-decanoylglycine
RHEA:26482	skos:altLabel	"tRNA prenyltransferase"
RHEA:26482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA
RHEA:26482	skos:prefLabel	"tRNA dimethylallyltransferase"
RHEA:26482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA dimethylallyltransferase"
RHEA:26482	skos:altLabel	"IPP transferase"
RHEA:72913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atranorin + S-adenosyl-L-homocysteine => proatranorin III + S-adenosyl-L-methionine
REACT:R-HSA-1977958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with ERBB3 (Homo sapiens)
REACT:R-RNO-193669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)
REACT:R-HSA-9736984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter (Homo sapiens)
REACT:R-MMU-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Mus musculus)
REACT:R-BTA-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Bos taurus)
REACT:R-HSA-5362793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np is cleaved by ADAM17 to promote ligand shedding (Homo sapiens)
RHEA:29420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Na(+)(in) => H(+)(in) + Na(+)(out)
RHEA:16507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + pyruvate => chorismate
REACT:R-CFA-430183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK binds PAK (Canis familiaris)
RHEA:54583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end dephospho-ribonucleoside-RNA + ATP <=> a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)
REACT:R-BTA-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Bos taurus)
EC:4.2.2.7	skos:altLabel	"heparin eliminase"
EC:4.2.2.7	skos:altLabel	"heparinase"
EC:4.2.2.7	skos:prefLabel	"heparin lyase"
EC:4.2.2.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heparin lyase"
GO:0050141	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitroethane reductase activity
GO:0050141	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitroethane:oxygen oxidoreductase activity
GO:0050141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitroethane oxidase activity
RHEA:27668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + propanoyl-CoA => (R)-methylmalonyl-CoA + H(+)
GO:0047034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	15-hydroxyeicosatetraenoate dehydrogenase activity
GO:0047034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxyicosatetraenoate dehydrogenase activity
GO:0047034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity
REACT:R-GGA-5654422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS2 (Gallus gallus)
REACT:R-CEL-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Caenorhabditis elegans)
REACT:R-RNO-937032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
RHEA:55621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carotenoid psi-end group => a carotenoid beta-end derivative
GO:0003756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	disulphide bond biosynthesis
GO:0003756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein disulphide isomerase activity
GO:0003756	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein disulfide-isomerase
GO:0003756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein thiol-disulphide exchange
GO:0003756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	disulphide bond formation
GO:0003756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein disulfide isomerase activity
GO:0003756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein thiol-disulfide exchange
GO:0003756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein cysteine-thiol oxidation
GO:0003756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein disulfide-isomerase reaction
GO:0003756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-S rearrangase activity
REACT:R-MMU-6799695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX5,6 reduce H2O2 to H2O (Mus musculus)
REACT:R-SSC-8862700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMKLR1 binds Resolvin E1 (Sus scrofa)
RHEA:28858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + melibiose(in) <=> H(+)(out) + melibiose(out)
RHEA:57273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA
REACT:R-SSC-8951486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C4b (Sus scrofa)
REACT:R-HSA-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Homo sapiens)
GO:0051393	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nonmuscle alpha-actinin binding
GO:0051393	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-actinin 1 binding
GO:0051393	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-actinin 4 binding
GO:0051393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-actinin binding
REACT:R-SSC-8862084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PILRA,PILRB bind CD99 (Sus scrofa)
RHEA:49143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:50652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O
RHEA:30458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O <=> (-)-geosmin
REACT:R-BTA-174447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation on the C-strand of the telomere (Bos taurus)
RHEA:19531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isovitexin 2''-O-beta-D-glucoside + UDP => isovitexin + UDP-alpha-D-glucose
REACT:R-HSA-9690877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DMRT1 in testis differentiation (Homo sapiens)
RHEA:35606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1-phosphate + H2O <=> D-fructose + phosphate
REACT:R-CFA-8934446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC phosphorylates SHC1 (Canis familiaris)
REACT:R-SSC-5218854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y420-FYN is phosphorylated on S21 (Sus scrofa)
REACT:R-GGA-190268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to Klotho-bound FGF23 (Gallus gallus)
RHEA:14167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-L-aspartate => acetyl-CoA + L-aspartate
REACT:R-HSA-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Homo sapiens)
REACT:R-RNO-1474213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP1,8,9,13 (Rattus norvegicus)
RHEA:63167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tricosanoyl-taurine <=> taurine + tricosanoate
REACT:R-BTA-6794355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 binds mGluR1a,5 (Bos taurus)
GO:0047363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity
GO:0047363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triglucosylmonoalkylmonoacyl sulfotransferase activity
GO:0047363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triglucosylalkylacylglycerol sulfotransferase activity
GO:0047363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triglucosylalkylacylglycerol sulphotransferase activity
REACT:R-HSA-3371537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBC1 binds SIRT1 (Homo sapiens)
REACT:R-DDI-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Dictyostelium discoideum)
RHEA:16104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)
EC:3.6.4.12	skos:prefLabel	"DNA helicase"
EC:3.6.4.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA helicase"
RHEA:14928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol 1-phosphate + NADP(+) <=> D-mannose 6-phosphate + H(+) + NADPH
REACT:R-SSC-5693566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 associates with H4K20Me2 at DNA DSBs (Sus scrofa)
REACT:R-BTA-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Bos taurus)
RHEA:57978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside C-K + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose
GO:0102029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lactate dehydrogenase (quinone) activity
REACT:R-SSC-2029458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV1 to p-6Y-SYK (Sus scrofa)
RHEA:39551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)
REACT:R-BTA-2467794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of sister chromatids (Bos taurus)
RHEA:71055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L-methionine(out)
REACT:R-SCE-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Saccharomyces cerevisiae)
RHEA:32387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocarveol + NAD(+) = dihydrocarvone + H(+) + NADH
REACT:R-DME-77587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Replication Dependent Histone mRNA with the NPC (Drosophila melanogaster)
RHEA:27812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate + 2 diphosphate => dimethylallyl diphosphate + 2 isopentenyl diphosphate
GO:0102377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviol 13-O glucosyltransferase activity
REACT:R-SSC-9020277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Sus scrofa)
REACT:R-MMU-450595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR:mRNA complex translocates from the nucleus to the cytosol (Mus musculus)
REACT:R-SSC-6807008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates MET (Sus scrofa)
RHEA:45864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-CFA-1504186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL recruits GSK3beta:AXIN1 to the receptor complex (Canis familiaris)
RHEA:15535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfopyruvate + H(+) + NADH => (2R)-3-sulfolactate + NAD(+)
RHEA:43955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate
REACT:R-BTA-2090038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses heparan chain(2) (Bos taurus)
RHEA:21830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:39718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O
REACT:R-HSA-9768925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 gene expression is repressed by NPAS4 (Homo sapiens)
RHEA:42673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-L-cysteine + hercynine + O2 => gamma-L-glutamyl-hercynylcysteine S-oxide + H2O
REACT:R-DRE-380455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CDK11p58 to the centrosomes (Danio rerio)
RHEA:60819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A14 aldehyde + O2 <=> CO2 + gibberellin A14 + H(+) + succinate
REACT:R-RNO-159773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein S to protein S (Rattus norvegicus)
RHEA:54058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-HSA-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Homo sapiens)
RHEA:46041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + ATP => ADP + dCMP + H(+)
REACT:R-BTA-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Bos taurus)
REACT:R-XTR-5654697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
RHEA:46854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + H(+) + NADPH
REACT:R-HSA-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Homo sapiens)
REACT:R-GGA-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Gallus gallus)
REACT:R-SSC-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Sus scrofa)
REACT:R-PFA-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)
REACT:R-HSA-199079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epithelial cadherin binds to KLRG1 (Homo sapiens)
GO:0004136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadenosine kinase activity
GO:0004136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine-deoxyribonucleoside kinase activity
GO:0004136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:deoxyadenosine 5'-phosphotransferase activity
GO:0004136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyadenosine kinase (phosphorylating)
RHEA:35780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => mutildienyl diphosphate
REACT:R-MMU-75146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Mus musculus)
REACT:R-SSC-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
REACT:R-RNO-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Rattus norvegicus)
REACT:R-RNO-5696670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD1L is recruited to GG-NER site (Rattus norvegicus)
REACT:R-BTA-111804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)
REACT:R-CFA-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Canis familiaris)
REACT:R-SPO-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Schizosaccharomyces pombe)
RHEA:54870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-[ACP] + NAD(+) => (2E)-butenoyl-[ACP] + H(+) + NADH
REACT:R-DRE-983146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Danio rerio)
RHEA:52137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)
RHEA:19324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylaniline N-oxide <=> formaldehyde + N-methylaniline
RHEA:41046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA
RHEA:46453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-leucyl-tRNA(Leu) => cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)
REACT:R-HSA-6799203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
REACT:R-BTA-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Bos taurus)
RHEA:57062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ADP-D-ribose + H(+) => 2''-O-acetyl-ADP-D-ribose + H2O
REACT:R-MMU-1236967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alkalization of the phagosomal lumen by NOX2 (Mus musculus)
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate:acceptor oxidoreductase activity
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate dehydrogenase activity
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate reductase activity
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate dehydrogenase activity
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinic acid dehydrogenase activity
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl dehydrogenase activity
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate:(acceptor) oxidoreductase activity
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinodehydrogenase activity
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinic dehydrogenase activity
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate oxidoreductase activity
GO:0000104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fumaric hydrogenase activity
REACT:R-DRE-266328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Danio rerio)
GO:0018861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoate:CoA ligase activity
GO:0018861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoate-CoA ligase activity
RHEA:44105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanal + H2O + NAD(+) => decanoate + 2 H(+) + NADH
RHEA:65629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine
RHEA:68382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuccinamate + L-serine => 3-hydroxypyruvate + L-asparagine
REACT:R-DME-2161779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LXA4 is oxidised to 15k-LXA4 by HPGD (Drosophila melanogaster)
REACT:R-RNO-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)
REACT:R-HSA-9612440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds the MXD4 gene (Homo sapiens)
GO:0047794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arogenate dehydrogenase activity
GO:0047794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arogenate:NAD(+) oxidoreductase activity
GO:0047794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexadienyl dehydrogenase activity
GO:0047794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arogenate:NAD+ oxidoreductase (decarboxylating)
GO:0047794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arogenate:NAD+ oxidoreductase activity
GO:0047794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pretyrosine dehydrogenase activity
GO:0047794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arogenic dehydrogenase activity
RHEA:72902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-demethylbarbatate + S-adenosyl-L-methionine <=> proatranorin I + S-adenosyl-L-homocysteine
RHEA:27326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Gallus gallus)
REACT:R-GGA-2059926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPHP4 protein binds LATS proteins (Gallus gallus)
RHEA:36720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-hexacosenoylsphinganine
REACT:R-DME-9759202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Drosophila melanogaster)
REACT:R-MMU-9627350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) binds XIAP (Mus musculus)
REACT:R-CFA-5218827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 (NOX2) complex binds RAC1 (Canis familiaris)
RHEA:36817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-fucofuranose => dTDP-alpha-D-fucose
REACT:R-HSA-9630923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)
RHEA:49172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Caenorhabditis elegans)
REACT:R-DDI-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Dictyostelium discoideum)
RHEA:18848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NAD(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADH
RHEA:10456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maltose O-acetyltransferase"
RHEA:10456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-maltose = 1-O-acetylmaltose + CoA
RHEA:10456	skos:prefLabel	"maltose O-acetyltransferase"
GO:0048408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epidermal growth factor binding
GO:0048408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF binding
RHEA:33890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-secoisolariciresinol + 2 NAD(+) <=> (-)-matairesinol + 2 H(+) + 2 NADH
RHEA:24508	skos:altLabel	"9-ketoprostaglandin reductase"
RHEA:24508	skos:prefLabel	"prostaglandin-E2 9-reductase"
RHEA:24508	skos:altLabel	"prostaglandin-E2 9-oxoreductase"
RHEA:24508	skos:altLabel	"PGE2 9-ketoreductase"
RHEA:24508	skos:altLabel	"9-keto-prostaglandin E2 reductase"
RHEA:24508	skos:altLabel	"PGE2 9-oxoreductase"
RHEA:24508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2
RHEA:24508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prostaglandin-E2 9-reductase"
REACT:R-SSC-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Sus scrofa)
REACT:R-GGA-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Gallus gallus)
REACT:R-DME-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Drosophila melanogaster)
RHEA:42620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylureidoacrylate + H(+) + H2O = (Z)-2-methylaminoacrylate + CO2 + NH4(+)
REACT:R-DDI-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Dictyostelium discoideum)
REACT:R-MMU-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Mus musculus)
REACT:R-SSC-266051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HpETE is dehydrated to LTA4 by ALOX5 (Sus scrofa)
RHEA:37974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)
RHEA:50330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-5691154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HFE binds TFRC dimer (Gallus gallus)
REACT:R-XTR-9012349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)
REACT:R-BTA-8952419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs ubiquitinate RUNX3 (Bos taurus)
RHEA:61142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + H2O + myricetin + succinate => (2R,3R)-dihydromyricetin + 2-oxoglutarate + O2
REACT:R-CEL-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Caenorhabditis elegans)
REACT:R-PFA-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Plasmodium falciparum)
RHEA:62140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + GTP = dTDP + GDP
REACT:R-HSA-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Homo sapiens)
RHEA:23767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-serine <=> H(+) + O-phospho-L-serine + phosphate
GO:0102367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-alpha-hydroxytaxusin 7-beta-hydroxylase activity
REACT:R-MMU-6813659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE, CTSG or PRTN3 binds bacteria (Mus musculus)
REACT:R-DRE-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)
RHEA:61030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein] => itaconate + L-cysteinyl-[protein]
RHEA:10178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH => (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+)
RHEA:69999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)
REACT:R-SSC-428262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Sus scrofa)
REACT:R-GGA-5693580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD52 with the RPA complex at resected DNA DSBs (Gallus gallus)
REACT:R-CEL-9624526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Caenorhabditis elegans)
GO:0052693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxyqueuosine reductase activity
REACT:R-MMU-5692408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPR2 binds NPPC (Mus musculus)
RHEA:64098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP] => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP]
RHEA:56154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine
RHEA:14496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] <=> ADP-D-ribose + L-arginyl-[dinitrogen reductase]
REACT:R-GGA-193641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKK-beta is recruited (Gallus gallus)
RHEA:25183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetylputrescine => acetyl-CoA + putrescine
REACT:R-DME-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Drosophila melanogaster)
REACT:R-BTA-8851494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase7 hydrolyzes nucleoside triphosphates (Bos taurus)
REACT:R-DME-426489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC binds inexactly matching target RNAs (Drosophila melanogaster)
REACT:R-CEL-400092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Caenorhabditis elegans)
REACT:R-HSA-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)
REACT:R-RNO-3222072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAXX binds Ub-MDM2 and USP7 (Rattus norvegicus)
RHEA:70758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)
REACT:R-GGA-4568863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RAD52 with SUMO1 (Gallus gallus)
RHEA:18693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + penicillin = 6-aminopenicillanate + a carboxylate
RHEA:18693	skos:prefLabel	"penicillin amidase"
RHEA:18693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"penicillin amidase"
RHEA:18693	skos:altLabel	"penicillin acylase"
RHEA:72796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin-bisglucuronoside(out) => bilirubin-bisglucuronoside(in)
REACT:R-CFA-3928595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ARP2/3 and G-actin (Canis familiaris)
RHEA:19199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphoramidate + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + NH4(+)
REACT:R-HSA-2404137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)
REACT:R-DME-3322431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds TLE (Drosophila melanogaster)
REACT:R-CFA-2160884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Canis familiaris)
REACT:R-CFA-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Canis familiaris)
REACT:R-SSC-2130336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial proteolyis of Ii by aspartic proteases to lip22 (Sus scrofa)
REACT:R-SSC-2404137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)
REACT:R-HSA-4568740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-1 stimulates IL1A transcription (Homo sapiens)
REACT:R-SSC-420739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPRC6A can bind L-alpha amino acids and calcium (Sus scrofa)
RHEA:40087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-hydroxydocosanoate + NAD(+) = 22-oxodocosanoate + H(+) + NADH
REACT:R-CFA-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Canis familiaris)
REACT:R-RNO-429798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Rattus norvegicus)
RHEA:45649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-CEL-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
RHEA:65321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chrodrimanin E + O2 => chrodrimanin A + CO2 + succinate
REACT:R-BTA-9696268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds effectors (Bos taurus)
RHEA:56216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP
RHEA:58383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + nonan-1-ol <=> H(+) + NADPH + nonanal
GO:0034902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endosulfan sulfate hydrolase activity
RHEA:36487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine
RHEA:36487	skos:altLabel	"ACAPT"
RHEA:36487	skos:altLabel	"triamine/agmatine aminopropyltransferase"
RHEA:36487	skos:prefLabel	"N(1)-aminopropylagmatine synthase"
RHEA:36487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(1)-aminopropylagmatine synthase"
RHEA:36487	skos:altLabel	"agmatine aminopropyltransferase"
RHEA:36487	skos:altLabel	"agmatine/cadaverine aminopropyl transferase"
REACT:R-SPO-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Schizosaccharomyces pombe)
REACT:R-MMU-4093336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
REACT:R-DRE-163010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Down Regulation of Emi1 through Phosphorylation of Emi1 (Danio rerio)
RHEA:14377	skos:altLabel	"erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase"
RHEA:14377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-erythro-3-hydroxyaspartate aldolase"
RHEA:14377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-aspartate = glycine + glyoxylate
RHEA:14377	skos:prefLabel	"L-erythro-3-hydroxyaspartate aldolase"
REACT:R-DME-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Drosophila melanogaster)
REACT:R-CFA-9691215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFR2 dimer (Canis familiaris)
RHEA:66753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O => (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate
REACT:R-RNO-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Rattus norvegicus)
RHEA:26061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+) => Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine
RHEA:59011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + salicylaldehyde <=> H(+) + H2O2 + salicylate
REACT:R-RNO-193101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11A1 cleaves 20a,22b-DHCHOL (Rattus norvegicus)
REACT:R-MMU-8869633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NR to yield NMN (Mus musculus)
REACT:R-DME-2028583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS2 (Drosophila melanogaster)
REACT:R-XTR-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Xenopus tropicalis)
GO:0018725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-3,4-dihydrodiolphenanthrene sulphotransferase activity
GO:0018725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-3,4-dihydrodiolphenanthrene sulfotransferase activity
REACT:R-HSA-2730868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK7 by MEKK1 (Homo sapiens)
RHEA:71282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-leucine(out) + 2 Na(+)(out) <=> chloride(in) + L-leucine(in) + 2 Na(+)(in)
RHEA:40478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tributanoylglycerol + H2O <=> butanoate + dibutanoylglycerol + H(+)
REACT:R-SCE-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Saccharomyces cerevisiae)
RHEA:39728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin(in) => a sphingomyelin(out)
REACT:R-SPO-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Schizosaccharomyces pombe)
REACT:R-GGA-1250220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of ERBB4 (Gallus gallus)
REACT:R-HSA-9712084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)
REACT:R-CEL-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)
GO:0032028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin head/neck binding
REACT:R-XTR-2186767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SKI/SKIL (Xenopus tropicalis)
RHEA:63400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(II)-hydroxyheme i = Fe(II)-heme a + H2O
RHEA:49133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in tRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine
EC:2.3.2.26	skos:prefLabel	"HECT-type E3 ubiquitin transferase"
EC:2.3.2.26	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"HECT-type E3 ubiquitin transferase"
EC:2.3.2.26	skos:altLabel	"HECT E3 ligase"
EC:2.3.2.26	skos:altLabel	"ubiquitin transferase HECT-E3"
REACT:R-RNO-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Rattus norvegicus)
REACT:R-GGA-8949580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F1Fo ATP synthase dimerizes (Gallus gallus)
REACT:R-HSA-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Homo sapiens)
REACT:R-PFA-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Plasmodium falciparum)
REACT:R-RNO-377186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)
REACT:R-CEL-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Caenorhabditis elegans)
GO:0034804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzo(a)pyrene 11,12-epoxidase activity
REACT:R-CEL-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Caenorhabditis elegans)
RHEA:58907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH <=> C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)
REACT:R-RNO-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)
GO:0046702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactoside 6-L-fucosyltransferase activity
REACT:R-HSA-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)
REACT:R-DME-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Drosophila melanogaster)
REACT:R-DME-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Drosophila melanogaster)
RHEA:48506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-D-manno-heptose 1-phosphate + phosphate => D-glycero-D-manno-heptose 1,7-bisphosphate + H2O
REACT:R-SSC-8941312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Sus scrofa)
RHEA:39316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O
REACT:R-DRE-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Danio rerio)
EC:1.1.1.120	skos:prefLabel	"galactose 1-dehydrogenase (NADP(+))"
EC:1.1.1.120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactose 1-dehydrogenase (NADP(+))"
REACT:R-SSC-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Sus scrofa)
REACT:R-GGA-353356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reversal of Alkylation Damage By DNA Dioxygenases (Gallus gallus)
GO:0120153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent carbohydrate binding
RHEA:30775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pyridoxamine = H2O2 + NH4(+) + pyridoxal
RHEA:13853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-methyleneglutamate--ammonia ligase"
RHEA:13853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylene-L-glutamate + ATP + NH4(+) = 4-methylene-L-glutamine + AMP + diphosphate + H(+)
RHEA:13853	skos:altLabel	"4-methyleneglutamine synthetase"
RHEA:13853	skos:prefLabel	"4-methyleneglutamate--ammonia ligase"
REACT:R-MMU-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Mus musculus)
GO:0050297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)
GO:0050297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stizolobate synthase activity
GO:0052747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapyl alcohol dehydrogenase activity
GO:0052747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sinapyl-alcohol dehydrogenase activity
GO:0052747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapyl-alcohol:NADP+ oxidoreductase activity
REACT:R-DME-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Drosophila melanogaster)
RHEA:44216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoate + ATP + CoA = 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate
GO:0015127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin transmembrane transporter activity
RHEA:49490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate
REACT:R-SSC-1169403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 ligase with ISG15:E2 complex (Sus scrofa)
REACT:R-SSC-917835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from holoTF:TFRC dimer (Sus scrofa)
REACT:R-CFA-6811411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the Golgi (Canis familiaris)
RHEA:34023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH
RHEA:34023	skos:prefLabel	"nicotine blue oxidoreductase"
RHEA:34023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotine blue oxidoreductase"
RHEA:34023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH
REACT:R-DDI-4570554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO1 (Dictyostelium discoideum)
RHEA:32423	skos:prefLabel	"carvone reductase"
RHEA:32423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + A = (R)-carvone + AH2
RHEA:32423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carvone reductase"
RHEA:32423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-isodihydrocarvone + A = (S)-carvone + AH2
RHEA:47089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH
REACT:R-RNO-170044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Rattus norvegicus)
RHEA:36998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA
RHEA:18241	skos:prefLabel	"lysine 5,6-aminomutase"
RHEA:18241	skos:altLabel	"beta-lysine 5,6-aminomutase"
RHEA:18241	skos:altLabel	"adenosylcobalamin-dependent D-lysine 5,6-aminomutase"
RHEA:18241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate
RHEA:18241	skos:altLabel	"D-lysine 5,6-aminomutase"
RHEA:18241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine = (2R,5S)-2,5-diaminohexanoate
RHEA:18241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine 5,6-aminomutase"
RHEA:18241	skos:altLabel	"beta-lysine mutase"
REACT:R-BTA-8987043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22RA1 binds JAK1 (Bos taurus)
REACT:R-DRE-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Danio rerio)
REACT:R-DME-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Drosophila melanogaster)
GO:0047175	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-ACP:lyso-MGDG acyltransferase activity
GO:0047175	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity
GO:0047175	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity
GO:0047175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosylacylglycerol O-acyltransferase activity
REACT:R-GGA-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Gallus gallus)
REACT:R-SSC-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Sus scrofa)
REACT:R-PFA-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)
RHEA:49062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long chain fatty alcohol + FMN + H(+) + H2O => a long-chain alkane + FMNH2 + O2
REACT:R-XTR-201628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at DSVD (85) (Xenopus tropicalis)
REACT:R-CFA-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)
REACT:R-SSC-5621353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Sus scrofa)
REACT:R-XTR-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Xenopus tropicalis)
REACT:R-CFA-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Canis familiaris)
RHEA:54390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:31580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate
REACT:R-DRE-381537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Danio rerio)
REACT:R-DME-5684008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBN binds KPNA2 (Drosophila melanogaster)
REACT:R-DRE-5634100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 dissociates from RXRA:PPARD:atRA (Danio rerio)
REACT:R-SSC-8957389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Sus scrofa)
RHEA:65743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + nonyl sufate + O2 <=> CO2 + H(+) + nonanal + succinate + sulfate
REACT:R-DRE-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Danio rerio)
RHEA:23357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[rhodopsin] => ADP + H(+) + O-phospho-L-seryl-[rhodopsin]
REACT:R-MMU-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Mus musculus)
RHEA:40167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2
RHEA:71304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-methionine(out) + 2 Na(+)(out) => chloride(in) + L-methionine(in) + 2 Na(+)(in)
REACT:R-BTA-8854182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D17 binds OPTN:RAB8A (Bos taurus)
REACT:R-DRE-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Danio rerio)
RHEA:36743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptadecasphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine
REACT:R-RNO-399933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sema3A binds Nrp-1 bound to PlexinA (Rattus norvegicus)
REACT:R-CEL-5674130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Caenorhabditis elegans)
RHEA:46398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-XTR-6791109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds PCNA (Xenopus tropicalis)
RHEA:40641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-HSA-517536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Homo sapiens)
REACT:R-CFA-420724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds Ca2+ (Canis familiaris)
REACT:R-MMU-2130349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Generation of CLIP from lip10 (Mus musculus)
REACT:R-CFA-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Canis familiaris)
RHEA:23609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-isopropylammelide => cyanurate + isopropylamine
RHEA:58461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + CoA
RHEA:39173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyeicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH
REACT:R-XTR-6786012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Xenopus tropicalis)
REACT:R-HSA-9660829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2B binds Ade-Rib (Homo sapiens)
RHEA:71308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-valine(out) + 2 Na(+)(out) => chloride(in) + L-valine(in) + 2 Na(+)(in)
REACT:R-CFA-983422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of COPII coated vesicle (Canis familiaris)
RHEA:68632	skos:prefLabel	"ferredoxin--NAD(+) oxidoreductase (H(+)-transporting)"
RHEA:68632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin--NAD(+) oxidoreductase (H(+)-transporting)"
RHEA:68632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:68632	skos:altLabel	"Rnf complex"
REACT:R-HSA-4088441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXM1 stimulates CENPF transcription (Homo sapiens)
REACT:R-BTA-9025969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Bos taurus)
REACT:R-DRE-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Danio rerio)
REACT:R-BTA-5603467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C is released from PROCR (Bos taurus)
RHEA:66113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-tyrosine => (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate
GO:0005215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transporter activity
GO:0005215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carrier
RHEA:24052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:24052	skos:altLabel	"ETF-QO"
RHEA:24052	skos:altLabel	"ETF-ubiquinone oxidoreductase"
RHEA:24052	skos:prefLabel	"electron-transferring-flavoprotein dehydrogenase"
RHEA:24052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"electron-transferring-flavoprotein dehydrogenase"
RHEA:24052	skos:altLabel	"ETF dehydrogenase"
RHEA:24052	skos:altLabel	"electron transfer flavoprotein-ubiquinone oxidoreductase"
REACT:R-MMU-4093331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras:GTP binds p120-RasGAP (Mus musculus)
RHEA:42269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] => 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA
RHEA:51230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate
RHEA:70816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-histidine(in) + L-ornithine(out) => H(+)(out) + L-histidine(out) + L-ornithine(in)
GO:0140108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity glucose transmembrane transporter activity
REACT:R-SSC-375395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5a receptor binds C5a anaphylatoxin (Sus scrofa)
RHEA:51741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)
RHEA:20710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-erythritol 4-phosphate + H(+) => ATP + erythritol
REACT:R-XTR-9011748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R binds JAK1 (Xenopus tropicalis)
RHEA:19077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate
REACT:R-DRE-4615872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO1 (Danio rerio)
RHEA:53970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP] => apo-[BtrI ACP] + CoA
RHEA:11542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosaminolactone + H(+) + NADH => an N-acyl-D-mannosamine + NAD(+)
REACT:R-HSA-937029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)
RHEA:37137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate
RHEA:62326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide + FADH2 => (+)-malbrancheamide B + chloride + FAD + 2 H(+)
REACT:R-SSC-6806974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET dimers autophosphorylate (Sus scrofa)
RHEA:20905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxypropyl-coenzyme M => (S)-1,2-epoxypropane + coenzyme M
GO:0031402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+ ion binding
GO:0031402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium ion binding
REACT:R-SSC-159001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)
REACT:R-HSA-9668419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)
REACT:R-SPO-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Schizosaccharomyces pombe)
REACT:R-GGA-5610766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Gallus gallus)
RHEA:62669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyherqueinone + H(+) + NADPH + O2 => H2O + herqueinone + NADP(+)
REACT:R-DRE-9614423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO1 (Danio rerio)
REACT:R-RNO-975389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Rattus norvegicus)
GO:0070728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Leu binding
GO:0070728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucine binding
REACT:R-CFA-937337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Canis familiaris)
GO:0048307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferredoxin-nitrite reductase activity
GO:0048307	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonia:ferredoxin oxidoreductase activity
GO:0048307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] = 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]
GO:0048307	skos:prefLabel	"ferredoxin--nitrite reductase"
GO:0048307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin--nitrite reductase"
REACT:R-DRE-6804485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates L3MBTL2 with SUMO2 (Danio rerio)
REACT:R-SCE-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Saccharomyces cerevisiae)
REACT:R-SCE-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-HSA-3215295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates MDM2 (Homo sapiens)
REACT:R-XTR-5607722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK phosphorylates IKKA dimer (Xenopus tropicalis)
REACT:R-DME-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Drosophila melanogaster)
REACT:R-CFA-159773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein S to protein S (Canis familiaris)
REACT:R-SSC-201445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Sus scrofa)
REACT:R-DME-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Drosophila melanogaster)
RHEA:58473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate
REACT:R-HSA-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Homo sapiens)
REACT:R-CEL-5195402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LPIN (Caenorhabditis elegans)
REACT:R-XTR-5683888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMCD1 binds GATA6, sequestering it (Xenopus tropicalis)
REACT:R-DDI-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Dictyostelium discoideum)
RHEA:55287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + tetradecanoyl-CoA <=> all-trans-retinyl tetradecanoate + CoA
RHEA:48278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
REACT:R-DME-449073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-3 cleaves pro-interleukin-16 (Drosophila melanogaster)
RHEA:30727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + pyruvate = dADP + H(+) + phosphoenolpyruvate
REACT:R-CEL-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Caenorhabditis elegans)
REACT:R-SPO-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)
REACT:R-XTR-71010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUT isomerises L-MM-CoA to SUCC-CoA (Xenopus tropicalis)
RHEA:25577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + protoporphyrinogen IX => 3 H2O2 + protoporphyrin IX
RHEA:13545	skos:altLabel	"DMNT/TMTT homoterpene synthase"
RHEA:13545	skos:prefLabel	"trimethyltridecatetraene synthase"
RHEA:13545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trimethyltridecatetraene synthase"
RHEA:13545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] = (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:13545	skos:altLabel	"CYP92C6"
RHEA:13545	skos:altLabel	"CYP82G1"
RHEA:13545	skos:altLabel	"CYP92C5"
REACT:R-DRE-3371359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Danio rerio)
EC:2.4.1.232	skos:altLabel	"glycolipid 6-alpha-mannosyltransferase"
EC:2.4.1.232	skos:prefLabel	"initiation-specific alpha-1,6-mannosyltransferase"
EC:2.4.1.232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"initiation-specific alpha-1,6-mannosyltransferase"
EC:2.4.1.232	skos:altLabel	"alpha-1,6-mannosyltransferase"
RHEA:22717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-353125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteosome degrades ODC holoenzyme complex (Danio rerio)
REACT:R-SSC-352385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Sus scrofa)
GO:0051219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoprotein binding
GO:0051219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated protein binding
REACT:R-DME-173542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 ubiquitinates SMAD2 (Drosophila melanogaster)
RHEA:17171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => acetyl-CoA + alpha-D-galactosamine 1-phosphate
RHEA:10471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate + phosphate <=> acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
REACT:R-DME-5251955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Drosophila melanogaster)
RHEA:14670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H2O + NADP(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADPH
GO:0035439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)
GO:0035439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	halimadienyl diphosphate synthase activity
GO:0035439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	halimadienyl-diphosphate synthase activity
RHEA:60045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP
RHEA:50158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2
RHEA:35060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloramphenicol(in) + H(+)(out) => chloramphenicol(out) + H(+)(in)
REACT:R-RNO-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
RHEA:30036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 => benzene-1,2,4-triol + CO2 + H2O + NAD(+)
REACT:R-DRE-8932276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Danio rerio)
GO:0031210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine binding
RHEA:64433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-prolylglycine(out) => H(+)(in) + L-alanyl-L-prolylglycine(in)
REACT:R-HSA-5651657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)
REACT:R-DME-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Drosophila melanogaster)
RHEA:51264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-180602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Vif with APOBEC3G (Homo sapiens)
REACT:R-BTA-2752115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds CD44 (Bos taurus)
REACT:R-RNO-388605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMC(138-176) binds MC2R (Rattus norvegicus)
REACT:R-HSA-5545484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1 variants-defective DNA mismatch repair (Homo sapiens)
REACT:R-SSC-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Sus scrofa)
EC:3.2.1.88	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"non-reducing end beta-L-arabinopyranosidase"
EC:3.2.1.88	skos:altLabel	"beta-L-arabinoside arabinohydrolase"
EC:3.2.1.88	skos:altLabel	"beta-L-arabinosidase"
EC:3.2.1.88	skos:altLabel	"vicianosidase"
EC:3.2.1.88	skos:prefLabel	"non-reducing end beta-L-arabinopyranosidase"
REACT:R-BTA-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Bos taurus)
REACT:R-MMU-452100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to IL2 receptor is phosphorylated (Mus musculus)
REACT:R-CFA-5653886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1 binds LALBA (Canis familiaris)
REACT:R-DRE-139893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Granzyme-B activates BID by cleavage (Danio rerio)
REACT:R-DDI-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Dictyostelium discoideum)
REACT:R-DRE-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Danio rerio)
RHEA:67477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-glutamate => diphosphate + prekainate
GO:0004425	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]
GO:0004425	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleglycerol phosphate synthase activity
GO:0004425	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleglycerol phosphate synthetase activity
GO:0004425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-glycerol-phosphate synthase activity
GO:0004425	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-glycerophosphate synthase activity
GO:0004425	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)
REACT:R-RNO-5661120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Rattus norvegicus)
REACT:R-RNO-5138459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A:FZD4 is endocytosed (Rattus norvegicus)
REACT:R-CFA-2396029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-3 binds integrins (Canis familiaris)
REACT:R-SSC-8871226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA2 (Sus scrofa)
RHEA:47738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine
REACT:R-RNO-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Rattus norvegicus)
REACT:R-HSA-6805507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 binds AVEN (Homo sapiens)
GO:0008826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine sulfinate desulfinase activity
GO:0008826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine sulphinate desulphinase activity
GO:0008826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine + H2O = H(+) + L-alanine + sulfite
REACT:R-XTR-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Xenopus tropicalis)
RHEA:43263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
GO:0016502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide receptor activity
REACT:R-DDI-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Dictyostelium discoideum)
REACT:R-BTA-6800797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome activates CASP2 (Bos taurus)
RHEA:70144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:43893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-H + L-cysteine => [sulfur carrier]-SH + L-alanine
REACT:R-MTU-9635440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PapA5 transforms mycocerosyl to PDIM (Mycobacterium tuberculosis)
REACT:R-PFA-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Plasmodium falciparum)
REACT:R-XTR-2090085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan chain(1) (Xenopus tropicalis)
REACT:R-BTA-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)
REACT:R-MMU-5625416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anterograde IFT (Mus musculus)
REACT:R-MMU-5229283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCNs bind lipids (Mus musculus)
RHEA:15039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-methylputrescine + S-adenosyl-L-homocysteine => putrescine + S-adenosyl-L-methionine
REACT:R-CFA-5654408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS2 (Canis familiaris)
RHEA:54309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine
GO:0102998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulfomuconolactone hydrolase activity
REACT:R-BTA-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Bos taurus)
REACT:R-HSA-5654603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS3 (Homo sapiens)
RHEA:12170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + H(+) + NADPH => allyl alcohol + NADP(+)
RHEA:25425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GMP => 5-phospho-alpha-D-ribose 1-diphosphate + guanine
REACT:R-HSA-6805059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2:FACT phosphorylates TP53 (Homo sapiens)
REACT:R-RNO-6814549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA transcript initiation, Integrator binding, LEC binding (Rattus norvegicus)
REACT:R-CFA-5625745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 stimulates association of AR with NCOA2 (Canis familiaris)
REACT:R-MMU-9755306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub UBXN7 is degraded by the 26S proteasome (Mus musculus)
REACT:R-MMU-5665748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds RHOC:GTP (Mus musculus)
RHEA:71798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate(out) + H(+)(out) <=> (R)-3-hydroxybutanoate(in) + H(+)(in)
REACT:R-SPO-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Schizosaccharomyces pombe)
REACT:R-MMU-6784324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Mus musculus)
RHEA:31648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate
RHEA:51482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-4085028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE phosphorylates ManNAc to ManNAc-6-P (Gallus gallus)
RHEA:56900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine = globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP
REACT:R-SSC-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Sus scrofa)
RHEA:53409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
RHEA:67245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyglucosone + H2O + NAD(+) => 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH
REACT:R-HSA-114548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Homo sapiens)
REACT:R-GGA-1227755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IKK complex (Gallus gallus)
RHEA:71894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide
RHEA:34037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'-oxoparomamine + H2O2 => O2 + paromamine
GO:0016760	skos:altLabel	"UDP-glucose-beta-D-glucan glucosyltransferase"
GO:0016760	skos:prefLabel	"cellulose synthase (UDP-forming)"
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-beta-D-glucan glucosyltransferase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-cellulose glucosyltransferase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GS-I
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-cellulose glucosyltransferase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-glucan synthetase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-cellulose glucosyltransferase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-glucosyltransferase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-glucan synthase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-beta-glucan glucosyltransferase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucan synthase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellulose synthase (UDP-forming)"
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glucan synthase activity
GO:0016760	skos:altLabel	"UDP-glucose--beta-glucan glucosyltransferase"
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellulose synthase (UDP-forming) activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP
GO:0016760	skos:altLabel	"UDP-glucose-cellulose glucosyltransferase"
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-D-glucan synthase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-1,4-beta-glucan glucosyltransferase activity
GO:0016760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-glucan synthase activity
REACT:R-HSA-390459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of ADP for ATP in CCT/TriC:actin complex (Homo sapiens)
RHEA:17414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-CEL-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Caenorhabditis elegans)
GO:0004035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkaline phosphatase activity
GO:0004035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkaline phosphohydrolase activity
GO:0004035	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphomonoesterase activity
GO:0004035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkaline phosphomonoesterase activity
GO:0004035	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycerophosphatase activity
GO:0004035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphate-monoester phosphohydrolase (alkaline optimum)
GO:0004035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkaline phenyl phosphatase activity
GO:0004035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orthophosphoric-monoester phosphohydrolase (alkaline optimum)
RHEA:24752	skos:prefLabel	"red chlorophyll catabolite reductase"
RHEA:24752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"red chlorophyll catabolite reductase"
RHEA:24752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite = 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:24752	skos:altLabel	"red Chl catabolite reductase"
RHEA:24752	skos:altLabel	"RCCR"
RHEA:24752	skos:altLabel	"RCC reductase"
REACT:R-HSA-9672164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to mutant PDGFR receptor (Homo sapiens)
REACT:R-HSA-5617668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB3 mRNA is translated (Homo sapiens)
REACT:R-GGA-8849891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-3 bind to PSD-95 family members (Gallus gallus)
RHEA:63368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + spermine(out) = ADP + H(+) + phosphate + spermine(in)
REACT:R-BTA-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)
GO:0102551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate geranylgeranyl transferase activity
REACT:R-BTA-5693551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BRCA1-A complex at multiple sites by ATM (Bos taurus)
RHEA:49518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2
REACT:R-DME-5688276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT4 transfers ADPRib to GLUD (Drosophila melanogaster)
REACT:R-MMU-9605600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Mus musculus)
REACT:R-DRE-6814678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Danio rerio)
REACT:R-SSC-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Sus scrofa)
RHEA:20441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + O2 = 3-sulfino-L-alanine + H(+)
RHEA:20441	skos:prefLabel	"cysteine dioxygenase"
RHEA:20441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine dioxygenase"
REACT:R-GGA-2029467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)
RHEA:35085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + N'-monoacetylchitobiose-6'-phosphate => diacetylchitobiose-6'-phosphate + H2O
REACT:R-MMU-352029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Mus musculus)
RHEA:37868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-BTA-909718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of p-STAT1 homodimer (Bos taurus)
REACT:R-DRE-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Danio rerio)
RHEA:44867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)
REACT:R-DDI-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Dictyostelium discoideum)
REACT:R-HSA-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Homo sapiens)
RHEA:41658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + sanguinarine => dihydrosanguinarine + NADP(+)
RHEA:47357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an octanoate ester + H2O => an aliphatic alcohol + H(+) + octanoate
RHEA:63904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-phenylpyruvate + H(+) = H2O + phenguignardate
REACT:R-RNO-8862084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PILRA,PILRB bind CD99 (Rattus norvegicus)
REACT:R-DME-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Drosophila melanogaster)
REACT:R-DRE-6804942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 homodimers auto-ubiquitinate (Danio rerio)
RHEA:56382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2
REACT:R-CFA-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Canis familiaris)
REACT:R-DME-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Drosophila melanogaster)
RHEA:13520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dTMP <=> ADP + dTDP
RHEA:69622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
RHEA:11216	skos:prefLabel	"(deoxy)nucleoside-phosphate kinase"
RHEA:11216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(deoxy)nucleoside-phosphate kinase"
RHEA:11216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + ATP = a 2'-deoxyribonucleoside 5'-diphosphate + ADP
REACT:R-HSA-8939203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Homo sapiens)
REACT:R-DRE-4332356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK2 binds MAP3K7 (Danio rerio)
REACT:R-MMU-5688786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds RAD23 (Mus musculus)
REACT:R-MMU-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Mus musculus)
REACT:R-XTR-8942099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Xenopus tropicalis)
RHEA:36603	skos:prefLabel	"enduracididine beta-hydroxylase"
RHEA:36603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enduracididine beta-hydroxylase"
RHEA:36603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-enduracididine + O2 = (3S)-3-hydroxy-L-enduracididine + CO2 + succinate
REACT:R-RNO-350168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Rattus norvegicus)
REACT:R-DME-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Drosophila melanogaster)
GO:1904768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol binding
REACT:R-HSA-5649701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Homo sapiens)
REACT:R-XTR-380455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CDK11p58 to the centrosomes (Xenopus tropicalis)
GO:0000515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-aspartate(in) + L-glutamate(out) = H(+)(in) + L-aspartate(out) + L-glutamate(in)
GO:0000515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate:glutamate, proton antiporter activity
RHEA:60473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
RHEA:11827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate
RHEA:12071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]
REACT:R-PFA-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Plasmodium falciparum)
REACT:R-RNO-927830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Rattus norvegicus)
REACT:R-CFA-380455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CDK11p58 to the centrosomes (Canis familiaris)
REACT:R-MMU-211239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with chromatin (Mus musculus)
REACT:R-RNO-5668467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTNFR2 binds TNFA trimer:TNFR2 (Rattus norvegicus)
RHEA:44225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoate + ATP + CoA => 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate
REACT:R-SSC-2022911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSPG is secreted (Sus scrofa)
REACT:R-CFA-937075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated TAK1 leaves activated TLR receptor complex (Canis familiaris)
RHEA:56888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-dehydro-6-deoxy-alpha-D-glucose = UDP-4-dehydro-beta-L-rhamnose
REACT:R-DDI-9680865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4, CYP2B6 bind ritonavir (Dictyostelium discoideum)
REACT:R-SPO-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Schizosaccharomyces pombe)
RHEA:46778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-MMU-2855054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-2 binds to molecular patterns on the target cell surface  (Mus musculus)
REACT:R-MMU-3262512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Mus musculus)
REACT:R-BTA-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
REACT:R-RNO-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Rattus norvegicus)
REACT:R-SPO-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Schizosaccharomyces pombe)
RHEA:68452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-10'-apo-beta-carotenal + O2 = 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone
REACT:R-RNO-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Rattus norvegicus)
RHEA:49058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperlicin E + H2O + NADP(+) => asperlicin C + H(+) + NADPH + O2
EC:3.1.11.3	skos:prefLabel	"exodeoxyribonuclease (lambda-induced)"
EC:3.1.11.3	skos:altLabel	"lambda exonuclease"
EC:3.1.11.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exodeoxyribonuclease (lambda-induced)"
RHEA:50071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycoursodeoxycholate(in) + H2O <=> ADP + glycoursodeoxycholate(out) + H(+) + phosphate
RHEA:10562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate + NH4(+) => 4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O
REACT:R-SSC-73635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Sus scrofa)
REACT:R-XTR-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Xenopus tropicalis)
RHEA:49743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NADP(+)
RHEA:50601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[histone H2A] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]
RHEA:10715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + O2 <=> 2-phenylacetamide + CO2 + H2O
RHEA:62126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + GDP => a 2'-deoxyribonucleoside 5'-phosphate + GTP
RHEA:16006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate => 5-dehydro-4-deoxy-D-glucarate + H2O
REACT:R-CFA-8987084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)
RHEA:41259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan = (E)-3-(indol-3-yl)acrylate + NH4(+)
RHEA:41259	skos:prefLabel	"L-tryptophan ammonia lyase"
RHEA:41259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-tryptophan ammonia lyase"
RHEA:40984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)
REACT:R-CEL-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Caenorhabditis elegans)
REACT:R-HSA-9013979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)
RHEA:36583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH
RHEA:57899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate
REACT:R-CEL-1169404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ISG15 from E1 to E2 (UBCH8) (Caenorhabditis elegans)
RHEA:72596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) => H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)
RHEA:11690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-leucyl-tRNA(Leu) => ATP + L-leucine + tRNA(Leu)
REACT:R-BTA-5678261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Bos taurus)
RHEA:41295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(hexanoyl)sphing-4-enine = hexanoate + sphing-4-enine
REACT:R-RNO-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Rattus norvegicus)
REACT:R-DME-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Drosophila melanogaster)
REACT:R-RNO-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Rattus norvegicus)
REACT:R-XTR-8852874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 binds C3d, C3dg, iC3b (Xenopus tropicalis)
REACT:R-MMU-6805285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates TP53 (Mus musculus)
RHEA:49474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP => trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose
RHEA:17013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphoenolpyruvate = 3-phosphonopyruvate
RHEA:17013	skos:altLabel	"phosphoenolpyruvate phosphomutase"
RHEA:17013	skos:altLabel	"PEP mutase"
RHEA:17013	skos:prefLabel	"phosphoenolpyruvate mutase"
RHEA:17013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoenolpyruvate mutase"
RHEA:17013	skos:altLabel	"PEP phosphomutase"
REACT:R-HSA-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Homo sapiens)
REACT:R-RNO-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Rattus norvegicus)
RHEA:62585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-tyrosine(out) => ADP + H(+) + L-tyrosine(in) + phosphate
REACT:R-CEL-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Caenorhabditis elegans)
REACT:R-HSA-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Homo sapiens)
RHEA:47588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) = CMP + ganglioside GQ1c (d18:1(4E)) + H(+)
RHEA:37073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine
RHEA:68907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + ATP + H(+) + NADPH <=> 3-phenylpropanal + AMP + diphosphate + NADP(+)
GO:0042958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltodextrin transmembrane transporter activity
GO:0016433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (adenine) methyltransferase activity
RHEA:27755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylglyoxal => (R)-lactate + H(+)
REACT:R-SSC-8862090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Sus scrofa)
RHEA:21277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NADP(+) => D-xylulose + H(+) + NADPH
REACT:R-RNO-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)
REACT:R-SSC-5672958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from KSR1:MARK3 (Sus scrofa)
REACT:R-DME-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Drosophila melanogaster)
GO:0005144	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-13 receptor ligand
GO:0005144	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-13
GO:0005144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-13 receptor binding
REACT:R-BTA-8875482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin to ubiquitinated MET (Bos taurus)
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-glucose:quinone oxidoreductase activity
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose oxidase activity
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	microcid
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose-1-oxidase activity
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-glucose:oxygen 1-oxidoreductase activity
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	corylophyline
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GOD activity
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penatin
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose oxyhydrase activity
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-glucose:oxygen 1-oxido-reductase activity
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose oxidase activity
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose oxidase activity
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose aerodehydrogenase activity
GO:0046562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxin-1
REACT:R-RNO-8871370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Rattus norvegicus)
RHEA:45824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine = CO2 + ethanolamine
REACT:R-HSA-9683755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike protein gets N-glycosylated (Homo sapiens)
REACT:R-BTA-2731141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds fibronectin (Bos taurus)
RHEA:43481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-CEL-8868659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
REACT:R-CFA-9014294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the plasma membrane (Canis familiaris)
REACT:R-HSA-2564824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH reduces NDOR1:CIAPIN1 (Homo sapiens)
REACT:R-XTR-5623521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A (Xenopus tropicalis)
RHEA:49654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + violaceinate => H(+) + NADH + O2 + protoviolaceinate
RHEA:27817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(in) + Na(+)(in) <=> acetate(out) + Na(+)(out)
RHEA:66677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate
REACT:R-HSA-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Homo sapiens)
REACT:R-CFA-8954398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer hydrolyses cardiolipin to PA and PG (Canis familiaris)
RHEA:14277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactaldehyde dehydrogenase"
RHEA:14277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH
RHEA:14277	skos:prefLabel	"lactaldehyde dehydrogenase"
RHEA:64607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UTP <=> diphosphate + uridylyl-L-seryl-[protein]
GO:0052611	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carotene beta-ring hydroxylase activity
GO:0052611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-carotene 3-hydroxylase activity
GO:0052611	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-carotene hydroxylase activity
RHEA:48167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxypheophorbide a + H2O <=> H(+) + red chlorophyll catabolite
RHEA:68327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,5-bisphosphate + H2O <=> 1D-myo-inositol 2-phosphate + phosphate
REACT:R-HSA-1989764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CYP1A1 (Homo sapiens)
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pancellase SS
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	celluase A
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-1,4-beta-D-glucanase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-1,4-beta-glucanase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-1,4-endoglucan hydrolase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carboxymethyl cellulase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	9.5 cellulase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-1,4-glucanase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellulase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endoglucanase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoglucanase D
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alkali cellulase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellulosin AP
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	avicelase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellulase A 3
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	celludextrinase activity
GO:0008810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-1,4-beta-D-glucanohydrolase activity
REACT:R-HSA-9603548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3(496-641) binds NELFB (Homo sapiens)
REACT:R-CFA-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Canis familiaris)
REACT:R-SCE-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Saccharomyces cerevisiae)
RHEA:71443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-methyl-L-dopa(out) + L-phenylalanine(in) = 3-O-methyl-L-dopa(in) + L-phenylalanine(out)
REACT:R-CFA-389354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Vav1 (Canis familiaris)
RHEA:23203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-methyl-L-lysine + O2 <=> formaldehyde + H2O2 + L-lysine
RHEA:37181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate
REACT:R-DME-3858482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is recruited to the receptor (Drosophila melanogaster)
GO:0004484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	messenger RNA guanylyltransferase activity
GO:0004484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:mRNA guanylyltransferase activity
GO:0004484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein lambda2
GO:0004484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP--RNA guanylyltransferase activity
GO:0004484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mRNA capping enzyme activity
GO:0004484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA guanylyltransferase activity
REACT:R-CFA-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Canis familiaris)
REACT:R-RNO-430183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK binds PAK (Rattus norvegicus)
GO:0042979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine decarboxylase regulator activity
REACT:R-HSA-5678261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Homo sapiens)
REACT:R-DME-1638845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERK phosphorylates CERA to form C1P (Drosophila melanogaster)
GO:0016670	skos:prefLabel	"With oxygen as acceptor"
GO:0016670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
GO:0016670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
GO:0016670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor
RHEA:43559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
REACT:R-GGA-8949661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Gallus gallus)
REACT:R-DRE-201821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Danio rerio)
REACT:R-CEL-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Caenorhabditis elegans)
REACT:R-MMU-70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Mus musculus)
REACT:R-MMU-2562564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 processing within TLR4 complex (Mus musculus)
REACT:R-CFA-8953037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F8 forms homodimers (Canis familiaris)
RHEA:53489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)
GO:0080079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellobiose glucohydrolase activity
GO:0080079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose glucosidase activity
GO:0080079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellobiose glucosidase activity
REACT:R-HSA-201708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frizzled receptors bind Wnts (Homo sapiens)
RHEA:39894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + H(+) + vancomycin
RHEA:37098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA
REACT:R-GGA-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Gallus gallus)
GO:0015157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharide transmembrane transporter activity
GO:0015157	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endosomal oligosaccharide transporter
GO:0047736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellobiose epimerase"
GO:0047736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiose 2-epimerase activity
GO:0047736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose = beta-D-glucosyl-(1->4)-D-mannopyranose
GO:0047736	skos:prefLabel	"cellobiose epimerase"
GO:0047736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellobiose epimerase activity
RHEA:59170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate
EC:1.23.5.-	skos:prefLabel	"With a quinone or similar compound as acceptor"
EC:1.23.5.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
REACT:R-HSA-2660822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1 (Homo sapiens)
REACT:R-HSA-2161964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Homo sapiens)
REACT:R-RNO-4570493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Rattus norvegicus)
REACT:R-MMU-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Mus musculus)
REACT:R-CFA-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Canis familiaris)
RHEA:67911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary linear alkyl sulfate ester + H2O <=> a primary alcohol + H(+) + sulfate
RHEA:31028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl trans-(+)-abscisate + UDP
RHEA:59821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP => adenosine 3'-diphosphate,5'-triphosphate + AMP
GO:0008473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine cyclase activity
GO:0008473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OCD activity
GO:0008473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine cyclase (deaminating) activity
GO:0008473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine cyclodeaminase activity
GO:0008473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ornithine ammonia-lyase (cyclizing)
GO:0008473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ornithine ammonia-lyase (cyclizing; L-proline-forming)
REACT:R-HSA-3928594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate GIT1 (Homo sapiens)
GO:0043849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras palmitoyltransferase activity
GO:0043849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyltransferase ERF2
GO:0043849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ERF2
GO:0043849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHHC cysteine-rich domain-containing protein ERF2
GO:0043849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras protein acyltransferase activity
REACT:R-HSA-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Homo sapiens)
REACT:R-HSA-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
RHEA:57354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin
GO:0140232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential
GO:0140232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
RHEA:66264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + nonanoate = diphosphate + nonanoyl-AMP
RHEA:71990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene C
REACT:R-HSA-4615873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates SUZ12 with SUMO1 (Homo sapiens)
REACT:R-MMU-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Mus musculus)
REACT:R-HSA-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Homo sapiens)
RHEA:59360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine + H2O = beta-alanine + L-histidine
GO:0102259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacylglycerol acylhydrolase activity
REACT:R-SSC-5687640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Sus scrofa)
REACT:R-SSC-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Sus scrofa)
RHEA:20687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-tagatose + NADH => galactitol + NAD(+)
RHEA:25858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:11640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3R)-flavan-3-ol + 2 NAD(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH
RHEA:55313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
RHEA:58959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotide in RNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Bos taurus)
REACT:R-HSA-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Homo sapiens)
RHEA:55326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinyl hexadecanoate + CoA => 11-cis-retinol + hexadecanoyl-CoA
REACT:R-GGA-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Gallus gallus)
RHEA:16110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)
RHEA:45109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O
EC:3.2.1.70	skos:altLabel	"exo-1,6-alpha-glucosidase"
EC:3.2.1.70	skos:altLabel	"glucodextranase"
EC:3.2.1.70	skos:prefLabel	"glucan 1,6-alpha-glucosidase"
EC:3.2.1.70	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan 1,6-alpha-glucosidase"
REACT:R-CFA-5687758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP4C:PPP4R2 dephosphorylates RPA2 (Canis familiaris)
RHEA:14731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate
REACT:R-SSC-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Sus scrofa)
REACT:R-HSA-5684806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates CLEC1B dimer:PDPN (Homo sapiens)
REACT:R-HSA-5218891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)
REACT:R-MMU-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Mus musculus)
REACT:R-GGA-9023633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Gallus gallus)
REACT:R-GGA-982765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone forms dimers and oligomers (Gallus gallus)
RHEA:41016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA
RHEA:26183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate
REACT:R-CFA-176101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Rad17-RFC complex to DNA (Canis familiaris)
REACT:R-DRE-174448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex on the C-strand of the telomere (Danio rerio)
RHEA:21020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
RHEA:21020	skos:prefLabel	"chorismate synthase"
RHEA:21020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chorismate synthase"
RHEA:21020	skos:altLabel	"5-enolpyruvylshikimate-3-phosphate phospholyase"
REACT:R-DME-9008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds ESR1:estrogen:TGFA gene (Drosophila melanogaster)
RHEA:30934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + O-acetyl-L-homoserine <=> acetate + H(+) + L,L-cystathionine
REACT:R-CFA-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)
RHEA:44678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + an all-trans-retinyl ester => a triacyl-sn-glycerol + all-trans-retinol
REACT:R-SSC-5357432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL binds SRC-1 (Sus scrofa)
REACT:R-HSA-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Homo sapiens)
GO:0034956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphenyl ether 1,2-dioxygenase activity
REACT:R-DRE-193533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Danio rerio)
REACT:R-HSA-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Homo sapiens)
RHEA:19890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-glucose
REACT:R-HSA-9768832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRF binds NPAS4 gene promoter (Homo sapiens)
RHEA:47574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GT1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E))
RHEA:53337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20) in tRNA + NADP(+) => H(+) + NADPH + uridine(20) in tRNA
REACT:R-XTR-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Xenopus tropicalis)
REACT:R-XTR-373339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Xenopus tropicalis)
REACT:R-XTR-8938108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds cathepsin L (Xenopus tropicalis)
RHEA:59075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
RHEA:43220	skos:prefLabel	"16S rRNA (guanine(1516)-N(2))-methyltransferase"
RHEA:43220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (guanine(1516)-N(2))-methyltransferase"
RHEA:43220	skos:altLabel	"m(2)G(1516) methyltransferase"
RHEA:43220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:43052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-(methylthio)propionyl--CoA ligase"
RHEA:43052	skos:altLabel	"3-methylmercaptopropionyl-CoA ligase"
RHEA:43052	skos:altLabel	"MMPA-CoA ligase"
RHEA:43052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoate + ATP + CoA = 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate
RHEA:43052	skos:altLabel	"methylmercaptopropionate-coenzyme A ligase"
RHEA:43052	skos:prefLabel	"3-(methylthio)propionyl--CoA ligase"
REACT:R-MMU-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Mus musculus)
RHEA:13121	skos:prefLabel	"shikimate kinase"
RHEA:13121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"shikimate kinase"
RHEA:13121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + shikimate = 3-phosphoshikimate + ADP + H(+)
REACT:R-BTA-5218804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK activation by VEGFR (Bos taurus)
RHEA:34206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> aureusidin 6-O-beta-glucoside + H2O
RHEA:43538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate => 2 D-glyceraldehyde 3-phosphate
REACT:R-CFA-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Canis familiaris)
REACT:R-SCE-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Saccharomyces cerevisiae)
REACT:R-HSA-1630304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Homo sapiens)
RHEA:66364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O = 6-methyl-3,7-dioxodecanedioyl-CoA
RHEA:47525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
GO:0008375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc transferase activity
GO:0008375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylglucosaminyltransferase activity
GO:0047447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)
GO:0047447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)
GO:0047447	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-hydroxyaspartate dehydratase activity
GO:0047447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythro-beta-hydroxyaspartate dehydratase activity
GO:0047447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythro-3-hydroxyaspartate ammonia-lyase activity
GO:0047447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity
GO:0047447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythro-3-hydroxyaspartate dehydratase activity
GO:0047447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity
REACT:R-RNO-2424252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds collagen, fibronectin, aggrecan and matrilins (Rattus norvegicus)
RHEA:13302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a sterol => a 1-acyl-sn-glycerol + a sterol ester
REACT:R-CFA-9647619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD forms ring‐shaped oligomers  (Canis familiaris)
REACT:R-MMU-428205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [Golgi] (Mus musculus)
REACT:R-HSA-5617471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA1 gene is transcribed (Homo sapiens)
REACT:R-CEL-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Caenorhabditis elegans)
RHEA:13796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyleneglutarate <=> 2-methylene-3-methylsuccinate
REACT:R-GGA-2028284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Gallus gallus)
REACT:R-HSA-9686920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 ubiquitinates RIPK3 at K363 (Homo sapiens)
RHEA:23721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + propanoyl-CoA => (S)-methylmalonyl-CoA + ADP + H(+) + phosphate
GO:0043136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphatase activity
GO:0043136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGP:Mg2+ dimer hydrolyses 3PG to glycerol (Homo sapiens)
RHEA:64681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + ethanol => CoA + ethyl benzoate
REACT:R-HSA-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)
REACT:R-MMU-5205672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncleaved Pink1 accumulates in damaged mitochondria (Mus musculus)
RHEA:69099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-kynurenine <=> H2O + kynurenate + L-methionine
REACT:R-DRE-111966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 binds CALM1:4Ca2+ (Danio rerio)
RHEA:16699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + kynurenate => A + H2O + quinaldate
REACT:R-RNO-5654677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR2 (Rattus norvegicus)
REACT:R-BTA-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Bos taurus)
RHEA:31939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-1,4-benzoxazin-3-one monooxygenase"
RHEA:31939	skos:altLabel	"CYP71C3"
RHEA:31939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] = DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31939	skos:prefLabel	"2-hydroxy-1,4-benzoxazin-3-one monooxygenase"
REACT:R-DRE-166721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Danio rerio)
REACT:R-PFA-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Plasmodium falciparum)
GO:0003676	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	base pairing
GO:0003676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleic acid binding
REACT:R-BTA-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Bos taurus)
REACT:R-HSA-5607736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 oligomerizes (Homo sapiens)
REACT:R-HSA-111285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)
REACT:R-MMU-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Mus musculus)
REACT:R-XTR-561253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A12 exchanges extracellular urate for cytosolic LACT (Xenopus tropicalis)
RHEA:68764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine
REACT:R-BTA-983425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Bos taurus)
REACT:R-XTR-177671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Xenopus tropicalis)
REACT:R-RNO-8984023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Rattus norvegicus)
REACT:R-HSA-392751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)
RHEA:43114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + phenylglyoxylate => (R)-mandelate + NAD(+)
REACT:R-XTR-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-CFA-3222128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOC2L binds TP53 (Canis familiaris)
REACT:R-SPO-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Schizosaccharomyces pombe)
RHEA:43054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate => 3-(methylsulfanyl)propanoate + ATP + CoA
REACT:R-MMU-201790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 is dephosphorylated on Thr75 by PP2A (Mus musculus)
RHEA:12649	skos:prefLabel	"L-rhamnose 1-dehydrogenase"
RHEA:12649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnofuranose + NAD(+) = H(+) + L-rhamnono-1,4-lactone + NADH
RHEA:12649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-rhamnose 1-dehydrogenase"
REACT:R-DRE-2064406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Danio rerio)
REACT:R-HSA-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Homo sapiens)
GO:0102133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene hydroxylase activity
REACT:R-GGA-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)
REACT:R-GGA-975389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Gallus gallus)
GO:0043863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity
GO:0043863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HpaI
GO:0043863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HpcH
GO:0043863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHED aldolase activity
GO:0043863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-ketopimelate aldolase activity
REACT:R-GGA-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Gallus gallus)
REACT:R-HSA-9018863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Homo sapiens)
GO:0106293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 = H2O2 + NAD(+)
GO:0106293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH oxidase H202-forming activity
GO:0106293	skos:prefLabel	"NADH oxidase (H2O2-forming)"
GO:0106293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADH oxidase (H2O2-forming)"
GO:0106293	skos:altLabel	"H2O2-forming NADH oxidase"
REACT:R-DRE-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Danio rerio)
RHEA:15599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Fe(III)-siderophore(in) + ADP + H(+) + phosphate => a Fe(III)-siderophore(out) + ATP + H2O
RHEA:46938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+)
REACT:R-CEL-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Caenorhabditis elegans)
GO:0042324	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hypocretin receptor ligand
GO:0042324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orexin receptor binding
GO:0042324	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	orexin receptor ligand
GO:0042324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypocretin receptor binding
RHEA:53701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
RHEA:18526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol + NADP(+) => 3-methylbutanal + H(+) + NADPH
RHEA:27274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH
REACT:R-HSA-9007707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)
REACT:R-SSC-8865994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds PTPN11 (Sus scrofa)
REACT:R-HSA-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Homo sapiens)
REACT:R-BTA-5610722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI3 (Bos taurus)
GO:0018613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-fluorenone dioxygenase activity
REACT:R-CFA-5675433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP5 dephosphorylates RAF1 S338 (Canis familiaris)
REACT:R-SCE-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Saccharomyces cerevisiae)
GO:1990648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-4,5,6-triphosphate 5-phosphatase activity
GO:0097602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cullin family protein binding
GO:0097602	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cullin binding
REACT:R-DRE-211247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DNA by DFF40 (Danio rerio)
RHEA:58818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
RHEA:69393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
REACT:R-DRE-1638053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from keratan sulfate (Danio rerio)
RHEA:18876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-D-alanine + H2O <=> chloride + H(+) + NH4(+) + pyruvate
RHEA:71951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + sulfate(out) = 3 Na(+)(in) + sulfate(in)
REACT:R-MMU-400434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds fatty acids (Mus musculus)
REACT:R-CFA-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Canis familiaris)
REACT:R-CFA-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Canis familiaris)
REACT:R-CEL-193424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
RHEA:44541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-SSC-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Sus scrofa)
REACT:R-CFA-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Canis familiaris)
RHEA:51617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + formate + H(+) => CO2 + dATP + H2O
RHEA:67529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-octenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine
EC:1.16.9.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a copper protein as acceptor"
EC:1.16.9.-	skos:prefLabel	"With a copper protein as acceptor"
REACT:R-CFA-9024993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Canis familiaris)
REACT:R-MMU-8984012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Mus musculus)
REACT:R-RNO-5607747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MALT1 oligomers (Rattus norvegicus)
GO:0050393	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vinylacetyl-CoA delta3-delta2-isomerase activity
GO:0050393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vinylacetyl-CoA D-isomerase activity
GO:0050393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vinylacetyl-CoA delta-isomerase activity
GO:0050393	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vinylacetyl coenzyme A isomerase activity
GO:0050393	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	delta3-cis-delta2-trans-enoyl-CoA isomerase
GO:0050393	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vinylacetyl coenzyme A delta-isomerase activity
RHEA:65177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + protoaustinoid A => AH2 + protoaustinoid B
RHEA:17159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-phosphocreatine => ATP + creatine
GO:0022893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	low-affinity tryptophan permease activity
GO:0022893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity tryptophan transmembrane transporter activity
REACT:R-BTA-5617037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Bos taurus)
REACT:R-XTR-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Xenopus tropicalis)
REACT:R-CFA-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Canis familiaris)
GO:0061666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UFM1 ligase activity
GO:0061666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
REACT:R-BTA-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Bos taurus)
REACT:R-HSA-190790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of gap junction plaques (Homo sapiens)
GO:0009025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tagatose-1,6-bisphosphate triosephosphate lyase activity
GO:0009025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tagatose 1,6-diphosphate aldolase activity
GO:0009025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tagatose-bisphosphate aldolase activity
GO:0009025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)
GO:0009025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KbaY
GO:0009025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AgaY
GO:0009025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AgaZ
GO:0009025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-tagatose-1,6-bisphosphate aldolase activity
GO:0009025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tagatose-1,6-bisphosphate aldolase 1
REACT:R-CFA-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Canis familiaris)
GO:0035614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA hairpin loop binding
GO:0035614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA stem-loop binding
GO:0035614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small nuclear RNA stem-loop binding
GO:0035614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA hairpin binding
REACT:R-CFA-9701488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates JAK3 (Canis familiaris)
RHEA:25005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]
RHEA:53297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH
REACT:R-RNO-5617138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)
RHEA:12476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-glutamate = formate + L-glutamate
RHEA:12476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-formylglutamate deformylase"
RHEA:12476	skos:prefLabel	"N-formylglutamate deformylase"
RHEA:12476	skos:altLabel	"beta-citryl-L-glutamate hydrolase"
RHEA:49828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-XTR-9707353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 binds Aromatase inhibitors (Xenopus tropicalis)
REACT:R-MMU-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Mus musculus)
RHEA:48366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose
REACT:R-BTA-5638157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Bos taurus)
REACT:R-GGA-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Gallus gallus)
RHEA:26336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O <=> 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin
REACT:R-RNO-2046222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Rattus norvegicus)
RHEA:15813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"imidazole N-acetyltransferase"
RHEA:15813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1H-imidazole + acetyl-CoA = CoA + N-acetylimidazole
RHEA:15813	skos:altLabel	"imidazole acetylase"
RHEA:15813	skos:prefLabel	"imidazole N-acetyltransferase"
REACT:R-HSA-3222237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMYD2 methylates TP53 (Homo sapiens)
REACT:R-HSA-5419281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)
REACT:R-XTR-9696179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Xenopus tropicalis)
RHEA:16630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl-CoA => acetyl-CoA + glyoxylate
RHEA:45391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine
RHEA:29062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + H2 + ubiquinone-8 <=> 2 H(+)(out) + ubiquinol-8
RHEA:49272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] = calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Dictyostelium discoideum)
RHEA:60011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA precursor + 2 CTP <=> a tRNA with a 3' CC end + 2 diphosphate
REACT:R-BTA-399712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Bos taurus)
REACT:R-DRE-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Danio rerio)
REACT:R-DRE-1297444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of cAMP to HCN channels (Danio rerio)
REACT:R-RNO-9714483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the ER membrane (Rattus norvegicus)
REACT:R-GGA-212252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Gallus gallus)
REACT:R-SCE-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Saccharomyces cerevisiae)
RHEA:58638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenamide + glyoxylate => N-(9Z-octadecenoyl)-(2S)-hydroxyglycine
RHEA:52087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-octadecanoyloxy-octadecanoate + H2O <=> 13-hydroxy-octadecanoate + H(+) + octadecanoate
REACT:R-GGA-9013108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOC (Gallus gallus)
RHEA:67133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH => (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)
RHEA:54777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)
EC:1.16.5.-	skos:prefLabel	"With a quinone or similar compound as acceptor"
EC:1.16.5.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
REACT:R-RNO-2327746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 aggregation (Rattus norvegicus)
RHEA:68470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-gamma-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate
REACT:R-HSA-9615829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 gene expression is inhibited by MECP2 (Homo sapiens)
REACT:R-DDI-6797961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHDH oxidises Cho to BETALD (Dictyostelium discoideum)
REACT:R-BTA-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Bos taurus)
RHEA:13140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloartenol + S-adenosyl-L-methionine <=> cyclolaudenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-8875576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK,CRKL recruits RAC1 GEF to activated MET (Homo sapiens)
RHEA:36126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine
RHEA:51033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloroindole-3-pyruvate imine dimer => dichlorochromopyrrolate + H(+) + NH4(+)
REACT:R-DRE-4641260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL1 is degraded by the proteasome (Danio rerio)
REACT:R-CFA-8950485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Canis familiaris)
REACT:R-MMU-2247513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1:ligand is endocytosed (Mus musculus)
REACT:R-HSA-159790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)
REACT:R-BTA-110376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Bos taurus)
RHEA:29426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + diphosphate <=> ADP + H(+) + triphosphate
RHEA:60694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-enoate + 2 H(+) + NADPH => (E)-non-2-enal + H2O + NADP(+)
REACT:R-DDI-2129362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin microfibril assembly (Dictyostelium discoideum)
REACT:R-SSC-443986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor ACKR2 binds most inflammatory CC chemokines (Sus scrofa)
REACT:R-HSA-173483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAMBI interferes with the interaction of type I receptor with type II receptor (Homo sapiens)
RHEA:43413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-galactosylceramide + H2O => an N-acyl-sphingoid base + D-galactose
REACT:R-HSA-9007546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds RAD51 gene promoter (Homo sapiens)
RHEA:68274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-fatty acyl-L-seryl-[protein] => a fatty acyl-CoA + L-seryl-[protein]
RHEA:55075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + H(+) <=> CO2 + propanal
RHEA:28265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose <=> 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP
REACT:R-SSC-9034855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK3 (Sus scrofa)
REACT:R-RNO-1602417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Rattus norvegicus)
RHEA:45406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate
REACT:R-DRE-982768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GH:GHR:JAK2 complex undergoes a conformational change (Danio rerio)
REACT:R-DDI-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Dictyostelium discoideum)
REACT:R-DME-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Drosophila melanogaster)
REACT:R-HSA-2214330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of collagen VII NC2 region by BMP1 (Homo sapiens)
REACT:R-XTR-5654597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)
RHEA:10749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogencarbonate => CO2 + H2O
REACT:R-RNO-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Rattus norvegicus)
RHEA:66033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose
RHEA:53101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone + S-adenosyl-L-methionine => 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine
RHEA:26508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + NH4(+) => (9Z)-octadecenamide + H2O
REACT:R-CFA-389622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Canis familiaris)
REACT:R-RNO-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Rattus norvegicus)
REACT:R-DME-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)
REACT:R-HSA-168317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Karyopherin Beta to form a Trimeric Complex (Homo sapiens)
REACT:R-DRE-162830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)
RHEA:21098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroshikimate + H2O => 3-dehydroquinate
REACT:R-CEL-8875568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 activates RAP1 (Caenorhabditis elegans)
REACT:R-DRE-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Danio rerio)
RHEA:58482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate => a cytidine in mRNA + acetyl-CoA + ATP + H2O
REACT:R-GGA-9668395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CC2D1B (Gallus gallus)
RHEA:32285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + quinolinate => 3-hydroxyanthranilate + O2
RHEA:23049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxybutanoate + 2-oxoglutarate => (R)-2-hydroxyglutarate + acetoacetate
REACT:R-DDI-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Dictyostelium discoideum)
RHEA:34655	skos:prefLabel	"botryococcene C-methyltransferase"
RHEA:34655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"botryococcene C-methyltransferase"
RHEA:34655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + 2 S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:45573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannuronosyl](n) => [alginate](n)
RHEA:30776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pyridoxamine => H2O2 + NH4(+) + pyridoxal
REACT:R-MMU-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Mus musculus)
REACT:R-DME-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Drosophila melanogaster)
REACT:R-CFA-216058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Canis familiaris)
REACT:R-XTR-8940554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2 cleaves OPTC (Xenopus tropicalis)
RHEA:68590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+) => (6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine
RHEA:35608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin + NADP(+) => diacetyl + H(+) + NADPH
REACT:R-HSA-1678742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses Heparan sulfate chain(4) (Homo sapiens)
GO:0031962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear mineralocorticoid receptor binding
GO:0031962	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	mineralocorticoid receptor binding
RHEA:36770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine
RHEA:56453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-hapalindole U
RHEA:68261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(in) + Na(+)(in) => D-serine(out) + Na(+)(out)
RHEA:46564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + apo-[ACP] = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-1433506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APS (Canis familiaris)
RHEA:50829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate
RHEA:19849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) + nicotinamide
REACT:R-HSA-8863008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calpain activation (Homo sapiens)
REACT:R-BTA-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Bos taurus)
REACT:R-DRE-6798258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTPRF, PTPRS, PTPRD bind LRRC4B (Danio rerio)
REACT:R-DME-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Drosophila melanogaster)
RHEA:41388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate
REACT:R-DRE-5633040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Danio rerio)
REACT:R-CEL-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Caenorhabditis elegans)
REACT:R-CFA-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Canis familiaris)
REACT:R-CFA-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Canis familiaris)
RHEA:14534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine + H2O => creatine
REACT:R-DRE-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Danio rerio)
REACT:R-MMU-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Mus musculus)
RHEA:24010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(omega)-phosphohypotaurocyamine => ATP + hypotaurocyamine
RHEA:23355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde
REACT:R-DRE-6784323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Danio rerio)
REACT:R-DME-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)
REACT:R-DDI-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:10826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + oxaloacetate => (S)-malate + NADP(+)
GO:0003682	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nuclear membrane vesicle binding to chromatin
GO:0003682	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	microtubule/chromatin interaction
GO:0003682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin binding
GO:0003682	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lamin/chromatin binding
RHEA:59878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-cysteine
REACT:R-CFA-210304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with PECAM1 (Canis familiaris)
RHEA:46001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H(+) + tuberculosinyl diphosphate => 1-tuberculosinyladenosine + diphosphate
RHEA:55284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA
REACT:R-HSA-5229283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCNs bind lipids (Homo sapiens)
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycosylphosphatidylinositol-specific phospholipase C activity
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	variant-surface-glycoprotein phospholipase C activity
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycosylphosphatidylinositol-phospholipase C activity
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPI-specific phospholipase C activity
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(glycosyl)phosphatidylinositol-specific phospholipase C activity
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	VSG-lipase activity
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPI-PLC activity
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosylphosphatidylinositol diacylglycerol-lyase activity
GO:0047396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity
RHEA:62967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)
RHEA:49094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O
RHEA:25028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + S-methyl-5'-thioadenosine <=> NH4(+) + S-methyl-5'-thioinosine
GO:0001093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIB-class transcription factor binding
REACT:R-SSC-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Sus scrofa)
REACT:R-GGA-3769383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBY1 binds beta-catenin (Gallus gallus)
RHEA:34666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
GO:0047089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine 12-hydroxylase activity
GO:0047089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine 12-monooxygenase activity
GO:0047089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)
RHEA:41687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)
REACT:R-SSC-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Sus scrofa)
GO:0004921	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gp130
GO:0004921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-11R
GO:0004921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-11 receptor activity
GO:0004921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-11 receptor activity
RHEA:65176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + protoaustinoid A = AH2 + protoaustinoid B
GO:0102039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH-dependent peroxiredoxin activity
GO:0102039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylhydroperoxide reductase activity
REACT:R-HSA-9021478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)
REACT:R-HSA-4085318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NCOA2 with SUMO1 (Homo sapiens)
REACT:R-GGA-9626928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP binds FOXO1 (Gallus gallus)
RHEA:52494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:16257	skos:prefLabel	"alpha,alpha-trehalose phosphorylase (configuration-retaining)"
RHEA:16257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate
RHEA:16257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha,alpha-trehalose phosphorylase (configuration-retaining)"
RHEA:16257	skos:altLabel	"trehalose phosphorylase"
GO:0015055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretin receptor activity
REACT:R-SSC-8857662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Sus scrofa)
REACT:R-DRE-420173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR1,CRHR2-1 binds CRH,UCN (Danio rerio)
GO:0019003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP binding
GO:0050093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol dehydrogenase activity
GO:0050093	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methanol:NAD+ oxidoreductase activity
GO:0017118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)
GO:0017118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoyltransferase activity
REACT:R-SPO-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Schizosaccharomyces pombe)
REACT:R-RNO-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Rattus norvegicus)
REACT:R-MMU-5678315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Mus musculus)
REACT:R-MMU-6808487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)
RHEA:20265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"proline 3-hydroxylase"
RHEA:20265	skos:prefLabel	"proline 3-hydroxylase"
RHEA:20265	skos:altLabel	"P-3-H"
RHEA:20265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-proline + O2 = cis-3-hydroxy-L-proline + CO2 + succinate
RHEA:39191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-docosenoyl-CoA + H(+) + NADPH = docosanoyl-CoA + NADP(+)
GO:0047042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alpha-HSD activity
GO:0047042	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)
GO:0047042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone dehydrogenase (B-specific) activity
GO:0047042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha-HSD
GO:0047042	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-alpha-hydroxysteroid dehydrogenase (B-specific) activity
GO:0047042	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha-hydroxysteroid dehydrogenase (B-specific)
GO:0047042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterognost 3alpha
GO:0047042	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha-hydroxysteroid oxidoreductase activity
GO:0047042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyprostaglandin dehydrogenase activity
REACT:R-RNO-8940070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NAD+ (Rattus norvegicus)
REACT:R-XTR-2022919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Xenopus tropicalis)
GO:0036354	skos:prefLabel	"bacteriochlorophyllide-a dehydrogenase"
GO:0036354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacteriochlorophyllide-a dehydrogenase"
GO:0036354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity
GO:0036354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) = 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH
GO:0036354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) = bacteriochlorophyllide a + H(+) + NADH
REACT:R-DDI-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Dictyostelium discoideum)
REACT:R-HSA-1222738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carboxymycobactin gets secreted (Homo sapiens)
REACT:R-XTR-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Xenopus tropicalis)
REACT:R-BTA-5693356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEMIP hydrolyses HA (Bos taurus)
REACT:R-HSA-741411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates NEMO (Homo sapiens)
REACT:R-HSA-9627078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP9 (Homo sapiens)
REACT:R-HSA-5603114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Homo sapiens)
REACT:R-CEL-183055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to EGFR (Caenorhabditis elegans)
RHEA:60124	skos:prefLabel	"sodorifen synthase"
RHEA:60124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-sodorifen diphosphate = diphosphate + sodorifen
RHEA:60124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sodorifen synthase"
REACT:R-XTR-2161187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Xenopus tropicalis)
RHEA:45527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]
GO:0004953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoid receptor activity
GO:0004953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	icosanoid receptor activity
REACT:R-BTA-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Bos taurus)
REACT:R-CFA-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Canis familiaris)
REACT:R-GGA-5218838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXN binds p-6Y,S732-PTK2 (Gallus gallus)
REACT:R-HSA-381607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Adenylyl cyclase synthesizes cyclic AMP (Homo sapiens)
REACT:R-GGA-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Gallus gallus)
REACT:R-HSA-9646347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 (Homo sapiens)
REACT:R-DDI-5651739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Dictyostelium discoideum)
REACT:R-MMU-166753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C4 into C4a and C4b (Mus musculus)
REACT:R-BTA-1169405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein phosphatase 1 beta (PP2CB) (Bos taurus)
GO:0034905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-chloro-4-hydroxy-2-oxopentanate aldolase activity
REACT:R-XTR-5578777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMPK phosphorylates PLN (Xenopus tropicalis)
RHEA:37758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-SCE-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Saccharomyces cerevisiae)
RHEA:40740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb2 + 2 H2O => (20S)-ginsenoside C-Y + 2 D-glucose
RHEA:60704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine
RHEA:20965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
RHEA:33771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)
REACT:R-MMU-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Mus musculus)
RHEA:22150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin] => a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin]
REACT:R-CFA-177920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2 to GAB1 (Canis familiaris)
REACT:R-MMU-9632039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)
REACT:R-HSA-1226014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
REACT:R-DME-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Drosophila melanogaster)
RHEA:54465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate
REACT:R-BTA-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Bos taurus)
REACT:R-HSA-390427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Homo sapiens)
REACT:R-CFA-4722133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Canis familiaris)
RHEA:70093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyclavatol ethyl ether => ethanol + o-quinone methide
REACT:R-DRE-2066299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 binds phosphorylated WWTR1 (TAZ) (Danio rerio)
GO:0004470	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic-malic carboxylase activity
GO:0004470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malic enzyme activity
REACT:R-GGA-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Gallus gallus)
REACT:R-RNO-3266557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I cleaves iC3b (Rattus norvegicus)
RHEA:10500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-ethylmalate synthase"
RHEA:10500	skos:altLabel	"3-ethylmalate glyoxylate-lyase (CoA-butanoylating)"
RHEA:10500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H(+)
RHEA:10500	skos:altLabel	"2-ethyl-3-hydroxybutanedioate synthase"
RHEA:10500	skos:prefLabel	"3-ethylmalate synthase"
RHEA:18287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + D-aspartate => an N-acyl-D-aspartate + H2O
REACT:R-CFA-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)
REACT:R-PFA-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Plasmodium falciparum)
RHEA:56932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH
RHEA:21907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-3-phosphoglycerate + phosphate
REACT:R-DRE-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Danio rerio)
RHEA:15908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxycyclohexanone + A <=> AH2 + cyclohexane-1,3-dione
RHEA:63371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + spermine(out) <=> ADP + H(+) + phosphate + spermine(in)
REACT:R-SSC-166214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion flip-flops to the opposite surface (Sus scrofa)
REACT:R-MMU-8953013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 binds E2F8 (Mus musculus)
GO:1990380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K48-linked deubiquitinase activity
GO:1990380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lys48-specific deubiquitinase activity
GO:1990380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Homo sapiens)
GO:1990380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K48-specific deubiquitinase activity
GO:1990380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K48-specific deubiquitinating activity
RHEA:22191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)
REACT:R-BTA-162729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Bos taurus)
REACT:R-BTA-165179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TSC1:TSC2 complex (Bos taurus)
RHEA:21657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-paratose => CDP-3,6-dideoxy-alpha-D-mannose
RHEA:47433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:59410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-aspartate => H2O + N-acetyl-L-aspartate
RHEA:36309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + acetyl-CoA => (E)-caffeoyl-CoA + H2O
REACT:R-HSA-9011950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive GREB1 gene transcription (Homo sapiens)
REACT:R-BTA-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Bos taurus)
RHEA:44205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoate + ATP + CoA => 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate
RHEA:65004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + decanoate + holo-[ACP] = AMP + decanoyl-[ACP] + diphosphate
GO:0000831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol hexakisphosphate 6-kinase activity
REACT:R-DDI-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Dictyostelium discoideum)
REACT:R-XTR-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Xenopus tropicalis)
REACT:R-GGA-879910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 is phosphorylated, activated (Gallus gallus)
RHEA:46477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CEL-5665989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIAPH1 binds RHOA:GTP (Caenorhabditis elegans)
REACT:R-CFA-5654159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds PLCG1 (Canis familiaris)
REACT:R-CFA-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Canis familiaris)
RHEA:53300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O = H(+) + N-carbamoyl-D-methionine
RHEA:32013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-T-muurolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-MMU-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Mus musculus)
REACT:R-DDI-2993447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6x(PCCA:PCCB) (Dictyostelium discoideum)
REACT:R-CFA-374663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Ezrin (Canis familiaris)
RHEA:66616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg(2+)(in) + 2 Na(+)(out) = Mg(2+)(out) + 2 Na(+)(in)
REACT:R-MMU-3244643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds cyclic GMP-AMP (Mus musculus)
RHEA:65300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chrodrimanin C + O2 = CO2 + H2O + succinate + verruculide A
REACT:R-CFA-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Canis familiaris)
REACT:R-XTR-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Xenopus tropicalis)
RHEA:41624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfinopropanoyl-CoA + H2O = H(+) + propanoyl-CoA + sulfite
RHEA:41624	skos:altLabel	"3SP-CoA desulfinase"
RHEA:41624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-sulfinopropanoyl-CoA desulfinase"
RHEA:41624	skos:altLabel	"3-sulfinopropionyl-CoA desulfinase"
RHEA:41624	skos:prefLabel	"3-sulfinopropanoyl-CoA desulfinase"
REACT:R-SSC-210291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Sus scrofa)
RHEA:64805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + S-(2-aminoethyl)-L-cysteine => CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine
REACT:R-RNO-9755303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades HIFalpha (Rattus norvegicus)
RHEA:48363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + H2O2 <=> a 2-hydroxy fatty acid + H2O
RHEA:16285	skos:altLabel	"ODH"
RHEA:16285	skos:altLabel	"octopine dehydrogenase"
RHEA:16285	skos:altLabel	"D-octopine synthase"
RHEA:16285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-octopine + H2O + NAD(+) = H(+) + L-arginine + NADH + pyruvate
RHEA:16285	skos:prefLabel	"D-octopine dehydrogenase"
RHEA:16285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-octopine dehydrogenase"
RHEA:40490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-CFA-6806629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tonofilament bundles (Canis familiaris)
RHEA:62526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine => cytidine(839) in 12S rRNA + S-adenosyl-L-methionine
REACT:R-RNO-202713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD84 homodimerises (Rattus norvegicus)
REACT:R-DRE-9648949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A antagonists bind HTR3A pentamer (Danio rerio)
REACT:R-GGA-994140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Gallus gallus)
RHEA:64624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + acetyl-CoA = (2E)-geranyl acetate + CoA
REACT:R-HSA-2426263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dystroglycan binds NRXN1 (Homo sapiens)
GO:0070907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine:histamine antiporter activity
GO:0070907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine/histamine antiporter activity
GO:0070907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-histamine antiporter activity
REACT:R-HSA-70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine => urocanate + NH4+ (Homo sapiens)
RHEA:65327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + chrodrimanin A <=> chrodrimanin B + CoA
RHEA:29260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate(out) + succinate(in) => (2R,3R)-tartrate(in) + succinate(out)
REACT:R-CFA-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Canis familiaris)
RHEA:33056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 3'-diphosphate 5'-triphosphate + H2O => diphosphate + GTP + H(+)
RHEA:34853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipyl-CoA + H(+) + NADH => (3S)-3-hydroxyadipyl-CoA + NAD(+)
EC:3.4.4.-	skos:prefLabel	"Peptidyl peptide hydrolases"
EC:3.4.4.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Peptidyl peptide hydrolases"
REACT:R-GGA-8851929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Gallus gallus)
RHEA:59580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester
REACT:R-SSC-3215251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53INP1 and HIPK2 bind TP53 (Sus scrofa)
REACT:R-DRE-4615873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates SUZ12 with SUMO1 (Danio rerio)
GO:0034202	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-coupled intramembrane glycolipid transporter activity
GO:0034202	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycolipid-translocating activity
GO:0034202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolipid floppase activity
GO:0034202	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP-dependent intramembrane glycolipid transporter activity
GO:0034202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolipid floppase activity (cytosolic to exoplasmic leaftlet)
GO:0102709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity
RHEA:70926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline(out) + chloride(out) + Na(+)(out) <=> (R)-noradrenaline(in) + chloride(in) + Na(+)(in)
GO:1990631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HER4 receptor binding
GO:1990631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ErbB-4 class receptor binding
GO:0015047	skos:prefLabel	"NADPH--cytochrome-c2 reductase"
GO:0015047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADPH--cytochrome-c2 reductase"
GO:0015047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)
GO:0015047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:ferricytochrome-c2 oxidoreductase activity
GO:0015047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)
GO:0015047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c2] + NADPH = 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)
GO:0015047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH-cytochrome-c2 reductase activity
RHEA:58254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + L-asparaginyl-[protein] => H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein]
RHEA:59830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + L-homocysteine => H2O + S-inosyl-L-homocysteine
RHEA:41402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-HSA-8948621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-20 microRNAs bind VAPA mRNA (Homo sapiens)
REACT:R-MMU-1168894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A/B dissociates from the Growth Hormone receptor (Mus musculus)
RHEA:18002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)
RHEA:56060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + hnu = CO2 + pentadecane
REACT:R-DRE-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Danio rerio)
RHEA:38859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP
RHEA:43384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]
RHEA:43384	skos:prefLabel	"protein arginine kinase"
RHEA:43384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein arginine kinase"
GO:0102156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-DHBA UDP-glucosyltransferase activity
REACT:R-PFA-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)
RHEA:41437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + cholesterol => cholesteryl (9Z-octadecenoate) + CoA
REACT:R-RNO-5205824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)
REACT:R-DRE-606349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mis18 complex binds the centromere (Danio rerio)
REACT:R-HSA-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Homo sapiens)
GO:0015535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucose:hydrogen symporter activity
GO:0015535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-fucose(in) = H(+)(out) + L-fucose(out)
GO:0015535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucose:proton symporter activity
RHEA:57822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n+1) + AMP => [phosphate](n) + ADP
RHEA:40819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-MMU-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Mus musculus)
RHEA:12512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate
RHEA:49083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5-oxide + FMNH2 + O2 <=> dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O
GO:0102282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketodihydrosphinganine (C18) reductase activity
RHEA:68718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + germacrene D => (2E,6E)-farnesyl diphosphate
RHEA:35468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)
RHEA:41000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine
RHEA:17010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate
RHEA:38948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Drosophila melanogaster)
GO:0034572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monodemethylisoproturon dimethylaminedehydrogenase activity
REACT:R-SSC-936941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Sus scrofa)
REACT:R-DDI-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Dictyostelium discoideum)
GO:0098626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylseleninic acid reductase activity
GO:0098626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)
REACT:R-CFA-1855172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Canis familiaris)
GO:0043867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaeosine tRNA-ribosyltransferase activity
GO:0043867	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TgtA
GO:0043867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaeal tRNA-guanine transglycosylase activity
GO:0043867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-deazaguanine tRNA-ribosyltransferase activity
RHEA:57809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-3-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite
REACT:R-RNO-5685838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex binds D-loop structures (Rattus norvegicus)
RHEA:64361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O
REACT:R-SPO-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Schizosaccharomyces pombe)
RHEA:29493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-muurola-4(14),5-diene + diphosphate => (2E,6E)-farnesyl diphosphate
GO:0043812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
GO:0043812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-4-phosphate phosphatase activity
GO:0043812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol 4-phosphate phosphatase activity
REACT:R-HSA-2316352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane (Homo sapiens)
REACT:R-DRE-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Danio rerio)
REACT:R-GGA-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Gallus gallus)
REACT:R-XTR-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Xenopus tropicalis)
GO:0034828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity
REACT:R-BTA-217258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO2:FAD:Mg2+ S-oxidises MTZ (Bos taurus)
REACT:R-CFA-6804724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates phosphorylated MDM4 (Canis familiaris)
REACT:R-HSA-9006850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor JAK phosphorylation (Homo sapiens)
REACT:R-HSA-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
REACT:R-SSC-1297354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acrosin Cleavage (Sus scrofa)
REACT:R-DDI-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Dictyostelium discoideum)
RHEA:48760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threitol + NAD(+) = H(+) + L-erythrulose + NADH
REACT:R-RNO-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Rattus norvegicus)
RHEA:13555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-galactose 1-phosphate + H(+) => alpha-D-galactose + ATP
REACT:R-HSA-6810474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Homo sapiens)
REACT:R-DME-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Drosophila melanogaster)
RHEA:32759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylornithine synthase"
RHEA:32759	skos:prefLabel	"methylornithine synthase"
RHEA:32759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine = (3R)-3-methyl-D-ornithine
RHEA:48800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)
REACT:R-MMU-380076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 1 (NK1) binds to substance P (Mus musculus)
REACT:R-CFA-877361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyrin binds ASC (Canis familiaris)
RHEA:32290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate
RHEA:18694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + penicillin => 6-aminopenicillanate + a carboxylate
GO:0034781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-cyclohexylformamide amidohydrolase activity
REACT:R-GGA-75238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL binds TRAIL receptors (Gallus gallus)
RHEA:43098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine
RHEA:44313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoylglycerol + H2O => glycerol + H(+) + tetradecanoate
RHEA:25117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)
RHEA:34034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-N-acetylparomamine + H2O <=> acetate + paromamine
REACT:R-XTR-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Xenopus tropicalis)
REACT:R-CFA-193995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 18-hydroxylates CORST to 18HCORST (Canis familiaris)
GO:0036441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantolactone reductase activity
GO:0050021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinonolactonase activity
GO:0050021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arabinono-1,4-lactone lactonohydrolase activity
RHEA:50747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glyphosate + O2 <=> 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)
REACT:R-MMU-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)
REACT:R-CEL-428510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Caenorhabditis elegans)
REACT:R-BTA-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Bos taurus)
REACT:R-HSA-373720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADK1 interaction with DCC (Homo sapiens)
REACT:R-CFA-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Canis familiaris)
RHEA:57117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(in) + L-glutamine(out) + Na(+)(in) => L-asparagine(out) + L-glutamine(in) + Na(+)(out)
REACT:R-CEL-2404134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4:atROL binds TTR (Caenorhabditis elegans)
GO:0047237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0047237	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I
GO:0047237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosaminyltransferase I activity
GO:0047237	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity
GO:0047237	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity
GO:0047237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity
RHEA:13001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O = 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate
RHEA:13001	skos:prefLabel	"5-phytase"
RHEA:13001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-phytase"
RHEA:70515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose = 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP
REACT:R-PFA-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Plasmodium falciparum)
REACT:R-SSC-909719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STAT2 to p-IFNAR1 (Sus scrofa)
RHEA:13235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate + guanine => guanosine + phosphate
RHEA:43994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2
GO:0032405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MutLalpha complex binding
REACT:R-XTR-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Xenopus tropicalis)
REACT:R-BTA-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Bos taurus)
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(8)-acetylspermidine deacetylase activity
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N8-monoacetylspermidine deacetylase activity
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(1)-acetylspermidine amidohydrolase activity
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N8-acetylspermidine amidohydrolase activity
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(8)-acetylspermidine amidohydrolase activity
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	8-N-acetylspermidine amidohydrolase activity
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N1-acetylspermidine amidohydrolase activity
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylspermidine deacetylase activity
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N-acetylspermidine deacetylase activity
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N8-acetylspermidine deacetylase activity
GO:0047611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(8)-monoacetylspermidine deacetylase activity
RHEA:29862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + H2O <=> 5-deoxy-D-ribose + adenine
REACT:R-RNO-2065539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:Importin beta-1 dissociates (Rattus norvegicus)
RHEA:65749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dodecyl sulfate + O2 => CO2 + dodecanal + H(+) + succinate + sulfate
REACT:R-CFA-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Canis familiaris)
REACT:R-HSA-9717383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPM4 transports Na+ from the extracellular region to the cytosol (Homo sapiens)
RHEA:59226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + hydropyrene => (2E,6E,10E)-geranylgeranyl diphosphate
RHEA:32939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-DME-3229181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALM1:Ca2+ binds CNG channel (Drosophila melanogaster)
RHEA:34503	skos:prefLabel	"(+)-epi-alpha-bisabolol synthase"
RHEA:34503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-epi-alpha-bisabolol synthase"
RHEA:34503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (+)-epi-alpha-bisabolol + diphosphate
RHEA:46058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-XTR-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Xenopus tropicalis)
RHEA:20920	skos:prefLabel	"2,4-dichlorophenol 6-monooxygenase"
RHEA:20920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-dichlorophenol 6-monooxygenase"
RHEA:20920	skos:altLabel	"2,4-dichlorophenol hydroxylase"
RHEA:20920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorophenol + H(+) + NADPH + O2 = 3,5-dichlorocatechol + H2O + NADP(+)
REACT:R-MMU-5683964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates EYA1-4 (Mus musculus)
RHEA:24778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-13(2)-carboxypyropheophorbide a + methanol => H2O + pheophorbide a
RHEA:58502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + NAD(+) + trimethylamine => glycine betaine + H(+) + NADH + O2
REACT:R-HSA-912470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)
REACT:R-MMU-166214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion flip-flops to the opposite surface (Mus musculus)
RHEA:58828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10R)-epoxy-octadecanoate + H2O = 9R,10R-dihydroxyoctadecanoate
RHEA:54136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(48) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
RHEA:62976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienamide + H2O = (9Z,12Z,15Z)-octadecatrienoate + NH4(+)
REACT:R-MMU-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Mus musculus)
RHEA:67984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-leucine = N-acetyl-D-leucine
RHEA:11641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3R)-flavan-3-ol + 2 NAD(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH
GO:0106076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-lysine-N-succinyltransferase activity
GO:0005456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetylneuraminate transmembrane transporter activity
GO:0005456	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CMP-sialic acid transmembrane transporter activity
REACT:R-XTR-8985973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Xenopus tropicalis)
REACT:R-GGA-173709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C7 binds C5b:C6 (Gallus gallus)
REACT:R-BTA-2396002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)
REACT:R-CFA-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Canis familiaris)
REACT:R-SCE-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Saccharomyces cerevisiae)
REACT:R-DRE-8986994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Danio rerio)
REACT:R-MMU-879411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Mus musculus)
REACT:R-SCE-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Saccharomyces cerevisiae)
REACT:R-CEL-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Caenorhabditis elegans)
REACT:R-DRE-9014420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the phagocytic vesicle membrane (Danio rerio)
REACT:R-MMU-8867044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)
REACT:R-MMU-4086036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate NRIP1 with SUMO1 (Mus musculus)
RHEA:42742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine
RHEA:40631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trioctadecanoylglycerol = 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate
RHEA:19425	skos:altLabel	"imidazoleacetic monooxygenase"
RHEA:19425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + imidazole-4-acetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD(+)
RHEA:19425	skos:altLabel	"imidazoleacetate hydroxylase"
RHEA:19425	skos:prefLabel	"imidazoleacetate 4-monooxygenase"
RHEA:19425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"imidazoleacetate 4-monooxygenase"
RHEA:71736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + succinate => formate + succinyl-CoA
REACT:R-CFA-176631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Canis familiaris)
RHEA:41014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) <=> (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)
RHEA:13316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + sarcosine <=> formaldehyde + glycine + H2O2
GO:0015473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fimbrial usher porin activity
RHEA:36617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine => 2-hydroxyoctadecanoyl-CoA + sphinganine
REACT:R-DME-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Drosophila melanogaster)
REACT:R-HSA-2255343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8A,10,13,14 exchange GDP for GTP (Homo sapiens)
REACT:R-DDI-8955285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)
REACT:R-DME-8873946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD3 deubiquitinates PTEN (Drosophila melanogaster)
RHEA:13575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate
RHEA:44709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
RHEA:66718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + D-fructose 6-phosphate => 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate
REACT:R-CFA-5624129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LZTFL1 binds the BBSome and prevents its traffic to the cilium (Canis familiaris)
RHEA:61629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanal => 1-piperideine + H2O
RHEA:27819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NAD(+) => 2-dehydro-L-idonate + H(+) + NADH
REACT:R-RNO-197268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)
REACT:R-CEL-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Caenorhabditis elegans)
REACT:R-HSA-1963578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds phosphorylated ERBB2 heterodimers (Homo sapiens)
RHEA:69394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate
REACT:R-HSA-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Homo sapiens)
REACT:R-SSC-177927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to EGF:EGFR:GRB2:GAB1 (Sus scrofa)
RHEA:54652	skos:prefLabel	"peregrinol diphosphate synthase"
RHEA:54652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peregrinol diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O
RHEA:54652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peregrinol diphosphate synthase"
REACT:R-CFA-390674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB1 bind ADR,NAd (Canis familiaris)
REACT:R-SSC-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Sus scrofa)
REACT:R-SSC-190520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Golgi  transport vesicles with microtubules (Sus scrofa)
REACT:R-MMU-8950398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX dissociates from IL27:EBI3 (Mus musculus)
GO:0005111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2 binding
GO:0005111	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heartless ligand
GO:0005111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heartless binding
GO:0005111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 fibroblast growth factor receptor binding
GO:0005111	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FGFR2 ligand
GO:0005111	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 fibroblast growth factor receptor ligand
GO:0051997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity
GO:0051997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate decarboxylase activity
GO:0051997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OHCU decarboxylase activity
RHEA:66050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate => 2-oxobutanoate + L-kynurenine
RHEA:24798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => (S)-2-amino-6-oxoheptanedioate
REACT:R-HSA-8983371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)
REACT:R-BTA-8878143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SMAD3 and SMAD4 (Bos taurus)
REACT:R-HSA-5617862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retinoic acid activates HOXA4 chromatin (Homo sapiens)
RHEA:56969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + pyruvate => dCDP + H(+) + phosphoenolpyruvate
GO:0047727	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyryl-CoA:isobutyryl-CoA mutase activity
GO:0047727	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isobutyryl coenzyme A mutase activity
GO:0047727	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methylpropanoyl-CoA CoA-carbonylmutase activity
GO:0047727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA mutase activity
RHEA:57221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GTP
REACT:R-MMU-187545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cks1 with SCF(Skp2) complex (Mus musculus)
RHEA:24576	skos:altLabel	"pyrophosphate phosphohydrolase"
RHEA:24576	skos:altLabel	"inorganic pyrophosphatase"
RHEA:24576	skos:altLabel	"diphosphate phosphohydrolase"
RHEA:24576	skos:prefLabel	"inorganic diphosphatase"
RHEA:24576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H2O = H(+) + 2 phosphate
RHEA:24576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inorganic diphosphatase"
REACT:R-DRE-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Danio rerio)
GO:0004616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
GO:0004616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6PGD activity
GO:0004616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphogluconic acid dehydrogenase activity
GO:0004616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0004616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphogluconic carboxylase activity
GO:0004616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-D-gluconate dehydrogenase activity
GO:0004616	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	6-phosphogluconic dehydrogenase activity
GO:0004616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphogluconate dehydrogenase (decarboxylating)
RHEA:24753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite => 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:28500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(hydroxymethyl)mycothiol => formaldehyde + mycothiol
REACT:R-BTA-6801675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates NPM1 (Bos taurus)
REACT:R-RNO-8863718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGFG1 binds VAMP7 (Rattus norvegicus)
REACT:R-SSC-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Sus scrofa)
RHEA:34650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + squalene <=> 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-209187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further phosphorylation of CI by CKIalphaepsilon (Drosophila melanogaster)
REACT:R-BTA-3134953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 or DHX9 binds MyD88 (Bos taurus)
REACT:R-BTA-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)
REACT:R-BTA-9014296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GEFs activate RAC2 (Bos taurus)
REACT:R-SSC-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)
REACT:R-MMU-159796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor IX to factor IX (Mus musculus)
RHEA:21535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione + glutathionylspermidine <=> ADP + H(+) + phosphate + trypanothione
RHEA:70648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(out) + H(+)(out) => D-serine(in) + H(+)(in)
RHEA:20959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + ATP + CoA <=> AMP + diphosphate + phenylacetyl-CoA
REACT:R-HSA-5625797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Homo sapiens)
REACT:R-DRE-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Danio rerio)
GO:0008265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mo-molybdopterin cofactor sulfurase activity
GO:0008265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdopterin cofactor sulfurase activity
GO:0008265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdopterin synthase sulfurylase activity
GO:0008265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mo-molybdopterin cofactor sulphurase activity
REACT:R-DME-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Drosophila melanogaster)
RHEA:43382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + phosphate => H2O + N(omega)-phospho-L-arginyl-[protein]
REACT:R-BTA-419351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF receptor binds platelet activating factor (Bos taurus)
REACT:R-CFA-5683077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate KDM4A,B (Canis familiaris)
REACT:R-MMU-5695957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Mus musculus)
REACT:R-DRE-111289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)
REACT:R-CEL-5654515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds HS (Caenorhabditis elegans)
REACT:R-CEL-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Caenorhabditis elegans)
RHEA:65839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate
GO:0102279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lecithin:11-cis retinol acyltransferase activity
REACT:R-DME-9621179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cinaciguat binds sGC:NO (Drosophila melanogaster)
GO:0034522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity
REACT:R-HSA-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Homo sapiens)
REACT:R-PFA-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)
RHEA:30050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetaldehyde + H2O + NAD(+) <=> chloroacetate + 2 H(+) + NADH
RHEA:55767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O <=> 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
REACT:R-XTR-8865613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Xenopus tropicalis)
REACT:R-RNO-8874705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Rattus norvegicus)
RHEA:15694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 => (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O
GO:0016411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylglycerol O-acyltransferase activity
RHEA:15655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-fructose 2,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate
REACT:R-CFA-205075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JNK phosphorylates BIM, BAD and other targets (Canis familiaris)
RHEA:27287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-acetoin + NAD(+) => diacetyl + H(+) + NADH
RHEA:61561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-GGA-8987266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Gallus gallus)
RHEA:60028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = 4-terpineol + diphosphate
REACT:R-RNO-9686521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2:CCNA phosphorylates TERF2 (Rattus norvegicus)
REACT:R-DRE-5656105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Danio rerio)
GO:0005520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF binding
GO:0005520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin-like growth factor binding
RHEA:57734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-retinol => A + all-trans-7,8-dihydroretinol
RHEA:29135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 2 H(+)(in) + nitrate = a menaquinone + 2 H(+)(out) + H2O + nitrite
REACT:R-SSC-5625416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anterograde IFT (Sus scrofa)
REACT:R-BTA-8866308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL translocates from RER membrane to SER lumen (Bos taurus)
REACT:R-GGA-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Gallus gallus)
RHEA:57028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)
RHEA:57170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + FADH2 => (R)-2-hydroxyglutarate + FAD + H(+)
REACT:R-RNO-1433508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC alpha interacts with and phosphorylates KIT (Rattus norvegicus)
RHEA:67094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + docosanoate(out) + H(+) + phosphate => ATP + docosanoate(in) + H2O
REACT:R-XTR-77274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)
REACT:R-CFA-173705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b binds C6 (Canis familiaris)
RHEA:70180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-maltotetraose => alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose
RHEA:17743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroshikimate + H(+) + NADH => NAD(+) + shikimate
REACT:R-DRE-6799959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP3,4 binds bacterial peptidoglycan (Danio rerio)
REACT:R-XTR-162742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Xenopus tropicalis)
REACT:R-SSC-2730904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Sus scrofa)
RHEA:46633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)
REACT:R-BTA-8855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR binds DAB1 (Bos taurus)
RHEA:31213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-adenosylselenomethionine + phosphate => ATP + H2O + L-selenomethionine
REACT:R-HSA-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Homo sapiens)
RHEA:58876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:14834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + CoA + 2 NAD(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH
RHEA:72756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP => 3',3',3'-c-tri-AMP + 3 diphosphate
REACT:R-HSA-391913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR2 binds FPR2 ligands (Homo sapiens)
RHEA:65360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
REACT:R-MMU-5250217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP binds ARL2BP (Mus musculus)
REACT:R-XTR-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Xenopus tropicalis)
RHEA:54696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate
RHEA:54696	skos:altLabel	"4-hydroxybenzoate adenylase"
RHEA:54696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoate adenylyltransferase FadD22"
RHEA:54696	skos:prefLabel	"4-hydroxybenzoate adenylyltransferase FadD22"
RHEA:60810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A20 + H2O => gibberellin A19 + H(+) + O2
REACT:R-SSC-5685994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Long-range resection of DNA DSBs by EXO1 or DNA2 (Sus scrofa)
REACT:R-DME-5689973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10,USP24,USP42 deubiquitinate TP53 (Drosophila melanogaster)
REACT:R-BTA-71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Bos taurus)
REACT:R-SCE-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Saccharomyces cerevisiae)
REACT:R-SSC-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Sus scrofa)
GO:0070273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-4-phosphate binding
RHEA:37704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
RHEA:42439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-ascorbate 6-phosphate(in) + L-histidyl-[protein]
REACT:R-CFA-6804762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 forms homotetramers (Canis familiaris)
RHEA:20519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-galactosamine => UDP-N-acetyl-alpha-D-glucosamine
RHEA:12429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH => benzene-1,2,4-triol + NAD(+)
RHEA:16146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:61439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H2O <=> AMP + H(+) + phosphate
RHEA:39932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)
EC:5.1.3.31	skos:altLabel	"ketose 3-epimerase"
EC:5.1.3.31	skos:prefLabel	"D-tagatose 3-epimerase"
EC:5.1.3.31	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-tagatose 3-epimerase"
EC:5.1.3.31	skos:altLabel	"L-ribulose 3-epimerase"
RHEA:17304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]
RHEA:68630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] => phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]
RHEA:55085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxypentanoyl-CoA + H2O => (3R)-3-hydroxypentanoate + CoA + H(+)
REACT:R-MMU-912727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds VAV (Mus musculus)
REACT:R-XTR-74712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of IRS-P from insulin receptor (Xenopus tropicalis)
REACT:R-SSC-5685156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2 (Sus scrofa)
REACT:R-RNO-9629195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Rattus norvegicus)
REACT:R-BTA-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Bos taurus)
REACT:R-GGA-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Gallus gallus)
REACT:R-GGA-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Gallus gallus)
REACT:R-XTR-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Xenopus tropicalis)
RHEA:51775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + phlorisobutanophenone <=> 4-prenylphlorisobutanophenone + diphosphate
REACT:R-HSA-8944216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XV (Homo sapiens)
RHEA:19500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate <=> beta-alanine + CO2
GO:0052772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brefeldin A hydrolase activity
GO:0052772	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	BFA esterase activity
GO:0052772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brefeldin A esterase activity
REACT:R-DDI-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Dictyostelium discoideum)
REACT:R-HSA-9634430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6R gene expression is enhanced by CEBPA (Homo sapiens)
RHEA:69331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate <=> 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur
RHEA:20746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin D2 + H(+) + NADPH => NADP(+) + prostaglandin D2
REACT:R-GGA-264678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Gallus gallus)
RHEA:17865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + H(+) + NADPH
RHEA:15965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
RHEA:38772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-PFA-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Plasmodium falciparum)
REACT:R-XTR-5683385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of BRCA1-A complex at DNA DSBs (Xenopus tropicalis)
REACT:R-HSA-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
REACT:R-CFA-8948800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNKS and TNKS2 PARylate PTEN (Canis familiaris)
REACT:R-XTR-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Xenopus tropicalis)
REACT:R-DRE-9700156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK dimer binds IRS1 (Danio rerio)
REACT:R-GGA-421453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial uptake and processing of ALAS1 (Gallus gallus)
RHEA:70293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + quinolin-4-ol => 3-(2-aminophenyl)-3-oxopropanal
REACT:R-CFA-5653786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)
REACT:R-XTR-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Xenopus tropicalis)
RHEA:72950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(out) + 2 Na(+)(out) <=> acetate(in) + 2 Na(+)(in)
RHEA:17644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine <=> agmatine + CO2
REACT:R-BTA-170055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Bos taurus)
RHEA:24765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
REACT:R-MMU-196026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dab2 is recruited to the junctional plaques (Mus musculus)
REACT:R-CFA-5669158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF2 binds PAK1 (Canis familiaris)
REACT:R-HSA-9684321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3 cleaves nsp1-4 (Homo sapiens)
RHEA:52736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate = (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-1980128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)
RHEA:70498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + 2 Na(+)(out) <=> D-glucose(in) + 2 Na(+)(in)
RHEA:64753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanylpentan-1-ol-L-cysteine + H2O => 3-sulfanyl-1-pentanol + NH4(+) + pyruvate
REACT:R-XTR-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Xenopus tropicalis)
RHEA:53294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-carbamoyl-L-methionine => H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin
RHEA:59506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein] => cholesterol + glycyl-L-cysteinyl-[protein] + H(+)
REACT:R-RNO-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Rattus norvegicus)
RHEA:71565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-acetylaminomethyl-dUMP in DNA + CoA + H(+) => 5-aminomethyl-dUMP in DNA + acetyl-CoA
REACT:R-XTR-193713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Xenopus tropicalis)
GO:0031846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotensin receptor binding
GO:0031846	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotensin receptor ligand
RHEA:50557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D2 => H2O + prostaglandin J2
REACT:R-RNO-6792871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNG1 recruits PP2A-PPP2R5C to MDM2 (Rattus norvegicus)
RHEA:58271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal glycine + NAD(+) <=> [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide
REACT:R-XTR-114354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP:Caspase-7 (Xenopus tropicalis)
RHEA:66107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine
RHEA:27434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione amide + NAD(+) => glutathione amide disulfide + H(+) + NADH
REACT:R-SSC-5661517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC comlex binds OTULIN (Sus scrofa)
REACT:R-SSC-6781922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds UFD1L:SKP2 (Sus scrofa)
RHEA:42417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + L-proline => (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)
GO:0140295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pathogen-derived receptor ligand activity
GO:0140295	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	innate receptor ligand activity
REACT:R-DME-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Drosophila melanogaster)
REACT:R-CEL-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Caenorhabditis elegans)
REACT:R-RNO-4420099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHB  (Rattus norvegicus)
REACT:R-DME-2453833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)
REACT:R-XTR-9724745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds aprotinin (Xenopus tropicalis)
RHEA:57841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3-bisphosphate + H2O => 1D-myo-inositol 1-phosphate + phosphate
EC:1.2.1.99	skos:prefLabel	"4-(gamma-glutamylamino)butanal dehydrogenase"
EC:1.2.1.99	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-(gamma-glutamylamino)butanal dehydrogenase"
REACT:R-XTR-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Xenopus tropicalis)
REACT:R-DRE-4608852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 ubiquitinates PRICKLE1 (Danio rerio)
RHEA:53265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0036218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP pyrophosphatase activity
GO:0036218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP diphosphatase activity
REACT:R-DDI-9026003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Dictyostelium discoideum)
RHEA:68096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)
RHEA:72053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(in) + estrone 3-sulfate(out) => butanoate(out) + estrone 3-sulfate(in)
REACT:R-DRE-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Danio rerio)
RHEA:65989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	previtamin D3 => calciol
RHEA:67031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O <=> (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate
RHEA:14639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate => 3'-phosphoadenylyl sulfate + a thiol
REACT:R-GGA-158218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)
RHEA:13990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
REACT:R-SSC-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Sus scrofa)
REACT:R-HSA-9625197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFAP binds LAMP2a multimer (Homo sapiens)
RHEA:52660	skos:prefLabel	"amino acid--[acyl-carrier-protein] ligase"
RHEA:52660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + ATP + holo-[ACP] = AMP + an L-alpha-aminoacyl-[ACP] + diphosphate
RHEA:52660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amino acid--[acyl-carrier-protein] ligase"
REACT:R-BTA-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Bos taurus)
REACT:R-SSC-5693346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CECRI deaminates Ade-Rib to Ino (Sus scrofa)
RHEA:18579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine
RHEA:27371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + acetyl-CoA + H(+) + NADH => acetoin + CoA + NAD(+)
GO:0001051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plastid single-subunit type RNA polymerase binding
RHEA:14507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite => 2 glutathione + thiosulfate
REACT:R-MMU-9692539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds HRH1 inverse agonists (Mus musculus)
RHEA:16183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine
REACT:R-RNO-9013361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEXT3 is cleaved to produce NICD3 (Rattus norvegicus)
REACT:R-MMU-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Mus musculus)
REACT:R-DRE-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Danio rerio)
GO:0140863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A-K127 ubiquitin ligase activity
GO:0140863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AK127 ubiquitin ligase activity
GO:0140863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone ubiquitin ligase activity (H2A-K127 specific)
RHEA:66791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-L-dopa + O2 <=> (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2
RHEA:65784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:60509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in mRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine
RHEA:71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamate(out) + 2 H(+)(out) = glycyl-L-glutamate(in) + 2 H(+)(in)
REACT:R-GGA-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Gallus gallus)
REACT:R-GGA-379395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates 3MT to HVA (Gallus gallus)
RHEA:62828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-CFA-1678921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length TLR3/7/8/9 binds to UNC93B1 (Canis familiaris)
REACT:R-MMU-211224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with DFF45 (Mus musculus)
REACT:R-RNO-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)
REACT:R-MMU-9718379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds chemical antagonists (Mus musculus)
RHEA:69718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + ATP + CoA <=> (indol-3-yl)acetyl-CoA + AMP + diphosphate
REACT:R-GGA-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Gallus gallus)
RHEA:35617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methylglyoxal + NADH => hydroxyacetone + NAD(+)
RHEA:12789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alditol + NADP(+) = an aldose + H(+) + NADPH
REACT:R-BTA-5654709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
REACT:R-MMU-9027628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises EPA to 5-HEPE (Mus musculus)
REACT:R-MMU-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Mus musculus)
REACT:R-DRE-8854209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A binds JFC1 (Danio rerio)
REACT:R-RNO-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Rattus norvegicus)
RHEA:63599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine
RHEA:54660	skos:prefLabel	"(S)-hydroxynitrile lyase"
RHEA:54660	skos:altLabel	"hydroxynitrile lyase"
RHEA:54660	skos:altLabel	"(S)-cyanohydrin producing hydroxynitrile lyase"
RHEA:54660	skos:altLabel	"(S)-oxynitrilase"
RHEA:54660	skos:altLabel	"oxynitrilase"
RHEA:54660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic (S)-hydroxynitrile = an aromatic aldehyde + hydrogen cyanide
RHEA:54660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-hydroxynitrile lyase"
RHEA:37768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-HSA-443978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR11 binds CCL19, CCL21 & CCL25 (Homo sapiens)
REACT:R-BTA-162730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Bos taurus)
REACT:R-HSA-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Homo sapiens)
REACT:R-HSA-2161961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EET(1) is hydrolysed to DHET(1) by EPHX2 (Homo sapiens)
REACT:R-DRE-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Danio rerio)
REACT:R-HSA-9629154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 recognizes and binds thymine glycol (Homo sapiens)
REACT:R-DDI-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Dictyostelium discoideum)
GO:0052916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23S rRNA (guanine(1835)-N(2))-methyltransferase activity
REACT:R-RNO-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Rattus norvegicus)
RHEA:52596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholoyl-CoA + NAD(+) = 3-oxocholan-24-oyl-CoA + H(+) + NADH
REACT:R-CEL-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Caenorhabditis elegans)
RHEA:19470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 nitric oxide + 2 O2 => H(+) + NAD(+) + 2 nitrate
RHEA:56886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(32) in tRNA + S-adenosyl-L-methionine
REACT:R-HSA-429449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk activation leads to SLP-76 activation (Homo sapiens)
RHEA:46587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-6786720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DECR2 reduces LCtE-CoA to t3enoyl-CoA (Danio rerio)
REACT:R-BTA-9008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 phosphorylates RUNX2 (Bos taurus)
REACT:R-CFA-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Canis familiaris)
REACT:R-GGA-140599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Gallus gallus)
RHEA:36561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+) => A + cis-4-hydroxy-D-proline
REACT:R-CFA-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Canis familiaris)
REACT:R-MMU-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Mus musculus)
REACT:R-SCE-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Saccharomyces cerevisiae)
REACT:R-DDI-9024881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Dictyostelium discoideum)
RHEA:53962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2
REACT:R-MMU-1358790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates ERBB3 (Mus musculus)
REACT:R-HSA-3214912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate MeK5-histone H3 (Homo sapiens)
REACT:R-GGA-5662606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds zinc (Gallus gallus)
REACT:R-BTA-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Bos taurus)
REACT:R-MMU-9645535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 phosphorylates TIFA (Mus musculus)
RHEA:60605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline
REACT:R-HSA-193787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Homo sapiens)
REACT:R-MMU-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Mus musculus)
REACT:R-DME-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Drosophila melanogaster)
RHEA:13255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP
REACT:R-HSA-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)
RHEA:54598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexadecanoyl-CoA + O2
RHEA:13550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-fucose 1-phosphate + GTP + H(+) => diphosphate + GDP-beta-L-fucose
REACT:R-GGA-8980228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Gallus gallus)
RHEA:71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + thiocyanate(in) => 2 Na(+)(out) + thiocyanate(out)
RHEA:54771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide
RHEA:22279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoaldehyde + H2O + NAD(+) <=> a 2-oxocarboxylate + 2 H(+) + NADH
REACT:R-PFA-983266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins bind microtubules (Plasmodium falciparum)
EC:3.4.24.54	skos:altLabel	"Trimeresurus metalloendopeptidase A"
EC:3.4.24.54	skos:altLabel	"mucrotoxin A"
EC:3.4.24.54	skos:prefLabel	"mucrolysin"
EC:3.4.24.54	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mucrolysin"
REACT:R-MMU-374331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bradykinin receptors B1 and B2 bind to bradykinin (Mus musculus)
REACT:R-HSA-6806425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates FANCC expression (Homo sapiens)
REACT:R-RNO-352385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Rattus norvegicus)
REACT:R-SSC-9615249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBs bind AGRT1 (Sus scrofa)
RHEA:65598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Danio rerio)
REACT:R-CEL-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Caenorhabditis elegans)
REACT:R-HSA-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Homo sapiens)
REACT:R-GGA-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Gallus gallus)
REACT:R-RNO-5693055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Rattus norvegicus)
RHEA:69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH
RHEA:46823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:54957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + OPC-6 => AMP + diphosphate + OPC-6-CoA
RHEA:28514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate
REACT:R-CFA-70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate + H2O => 4-imidazolone-5-propionate (Canis familiaris)
RHEA:63921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sphinga-4E,14Z-dienine => CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine
RHEA:19320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate <=> 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate
RHEA:18090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginyl-[protein] => L-citrullyl-[protein] + NH4(+)
REACT:R-DDI-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Dictyostelium discoideum)
REACT:R-MMU-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Mus musculus)
REACT:R-CFA-380927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK phosphorylates TSC1:TSC2 (Canis familiaris)
REACT:R-HSA-140842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n fibrin monomers -> fibrin multimer (Homo sapiens)
RHEA:25750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-927832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
REACT:R-GGA-3928598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of p190RhoGEF to p-FAK (Gallus gallus)
GO:0043886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of carboxysome shell
GO:0043886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	structural constituent of carboxysome
EC:3.5.99.-	skos:prefLabel	"In other compounds"
EC:3.5.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In other compounds"
REACT:R-DME-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Drosophila melanogaster)
RHEA:42092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-6798044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTG2 binds CCR4-NOT complex (Xenopus tropicalis)
REACT:R-BTA-5626227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CP110 and CEP97 dissociate from the centriole (Bos taurus)
REACT:R-CEL-2160874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses (HA)50 (Caenorhabditis elegans)
REACT:R-HSA-201457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP2 binds to the receptor complex (Homo sapiens)
RHEA:57047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apionate + NAD(+) <=> 3-oxoisoapionate + H(+) + NADH
RHEA:50271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
REACT:R-DRE-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Danio rerio)
REACT:R-GGA-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Gallus gallus)
REACT:R-GGA-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Gallus gallus)
REACT:R-DDI-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Dictyostelium discoideum)
REACT:R-DME-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Drosophila melanogaster)
GO:0052882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor
GO:0052882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a copper protein as acceptor"
GO:0052882	skos:prefLabel	"With a copper protein as acceptor"
REACT:R-BTA-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Bos taurus)
RHEA:54803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) <=> [nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA
REACT:R-SSC-6788855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3KRP phosphorylates PsiAm, RibAm (Sus scrofa)
GO:0102821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bixin methyltransferase activity
REACT:R-XTR-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Xenopus tropicalis)
RHEA:38848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-DRE-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Danio rerio)
EC:3.1.26.5	skos:prefLabel	"ribonuclease P"
EC:3.1.26.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease P"
GO:0097573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione oxidoreductase activity
RHEA:65230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + naphthalene-1,2-diol => (1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+)
REACT:R-CFA-3257122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Canis familiaris)
REACT:R-HSA-975040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAB-ZNF / KAP Interaction (Homo sapiens)
REACT:R-HSA-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Homo sapiens)
REACT:R-MMU-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Mus musculus)
EC:2.4.99.12	skos:altLabel	"lipid IVA KDO transferase"
EC:2.4.99.12	skos:prefLabel	"lipid IVA 3-deoxy-D-manno-octulosonic acid transferase"
EC:2.4.99.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipid IVA 3-deoxy-D-manno-octulosonic acid transferase"
EC:2.4.99.12	skos:altLabel	"3-deoxy-D-manno-oct-2-ulosonic acid transferase"
EC:2.4.99.12	skos:altLabel	"KDO transferase"
EC:2.4.99.12	skos:altLabel	"3-deoxy-manno-octulosonic acid transferase"
RHEA:22943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginine <=> ADP + H(+) + N(omega)-phospho-L-arginine
GO:0008421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain aminoacylase activity
GO:0008421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain acylglutamate amidase activity
GO:0008421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-fatty-acyl-glutamate deacylase activity
GO:0008421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acyl-glutamate deacylase activity
GO:0008421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity
GO:0008421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty-acyl-glutamate deacylase activity
REACT:R-CEL-561072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal uptake of organic cations (Caenorhabditis elegans)
REACT:R-RNO-5577050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Rattus norvegicus)
REACT:R-MMU-5362553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTUM releases Hh-Np:GPC5 from the plasma membrane (Mus musculus)
GO:0102726	skos:prefLabel	"4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase"
GO:0102726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIBOA beta-D-glucoside + H2O = D-glucose + DIBOA
GO:0102726	skos:altLabel	"DIMBOAGlc hydrolase"
GO:0102726	skos:altLabel	"DIMBOA glucosidase"
GO:0102726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase"
GO:0102726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIMBOA beta-D-glucoside + H2O = D-glucose + DIMBOA
GO:0102726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIMBOA glucoside beta-D-glucosidase activity
RHEA:32168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine => aerobactin + AMP + diphosphate + H(+)
REACT:R-RNO-5686073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-3Y-SHC1 (Rattus norvegicus)
RHEA:59330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylonate + H(+) => D-xylono-1,5-lactone + H2O
RHEA:33811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine = 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O
RHEA:43846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+) => (3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2
REACT:R-RNO-8866329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP lipidates APOB-100, forming a pre-VLDL (Rattus norvegicus)
REACT:R-RNO-177935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)
REACT:R-DDI-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Dictyostelium discoideum)
GO:0047136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethyl-p-aminoazobenzene oxide reductase activity
GO:0047136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(dimethylamino)phenylazoxybenzene reductase activity
GO:0047136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent DMAB N-oxide reductase activity
GO:0047136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity
GO:0047136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylaminoazobenzene N-oxide reductase activity
GO:0047136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity
GO:0047136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity
RHEA:18175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + NH4(+) => (R)-octopamine
RHEA:42472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzo-p-dioxin + NADH + O2 = 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)
REACT:R-SPO-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine deaminase activity
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine ammonia-lyase activity
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine ammonia-lyase activity
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine dehydrase activity
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine dehydratase activity
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine ammonia-lyase (2-oxobutanoate-forming)
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine deaminase activity
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine dehydratase activity
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine dehydratase activity
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine deaminase activity
GO:0004794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine hydro-lyase (deaminating) activity
REACT:R-HSA-6803978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-nitrosylation of cysteine residues in proteins by N2O3 (Homo sapiens)
REACT:R-SSC-5684006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translocates NBN to the nucleus (Sus scrofa)
REACT:R-HSA-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Homo sapiens)
REACT:R-DDI-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Dictyostelium discoideum)
RHEA:49018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => aurachin C epoxide
RHEA:67002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + 4 CoA + phlorisobutanophenone => 2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA
REACT:R-HSA-8954185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter (Homo sapiens)
RHEA:57413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-tyrosinal + NADP(+) => ATP + H(+) + L-tyrosine + NADPH
REACT:R-SSC-5624953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL13B binds INPP5E (Sus scrofa)
RHEA:56034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)
REACT:R-BTA-5340320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTP transports GSL from plasma membrane to ER membrane (Bos taurus)
REACT:R-SCE-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Saccharomyces cerevisiae)
REACT:R-XTR-3791149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Xenopus tropicalis)
REACT:R-RNO-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Rattus norvegicus)
EC:1.1.1.145	skos:altLabel	"3beta-hydroxy-5-ene steroid dehydrogenase"
EC:1.1.1.145	skos:altLabel	"progesterone reductase"
EC:1.1.1.145	skos:prefLabel	"3beta-hydroxy-Delta(5)-steroid dehydrogenase"
EC:1.1.1.145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3beta-hydroxy-Delta(5)-steroid dehydrogenase"
GO:0033956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-apiosyl-beta-glucosidase activity
GO:0033956	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity
GO:0033956	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity
GO:0033956	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	furcatin hydrolase activity
GO:0033956	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity
RHEA:52467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-CFA-981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3 convertases spontaneously dissociate (Canis familiaris)
REACT:R-DRE-9696275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds GTP (Danio rerio)
RHEA:32415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-isodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH
REACT:R-CFA-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Canis familiaris)
REACT:R-MMU-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Mus musculus)
REACT:R-BTA-420586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Necl-2 trans heterodimer interaction (Bos taurus)
REACT:R-DDI-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Dictyostelium discoideum)
REACT:R-CFA-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Canis familiaris)
RHEA:25139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) = 3-amino-2-oxopropyl phosphate + CO2
REACT:R-HSA-174157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cyclin B (Homo sapiens)
REACT:R-CFA-8855954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Canis familiaris)
RHEA:71232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(3+)-[Dph3] + NADH => 2 Fe(2+)-[Dph3] + H(+) + NAD(+)
GO:0018750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biuret amidohydrolase activity
REACT:R-DDI-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Dictyostelium discoideum)
EC:3.2.1.33	skos:altLabel	"amylo-1,6-glucosidase"
EC:3.2.1.33	skos:prefLabel	"amylo-alpha-1,6-glucosidase"
EC:3.2.1.33	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amylo-alpha-1,6-glucosidase"
EC:3.2.1.33	skos:altLabel	"dextrin 6-alpha-D-glucosidase"
REACT:R-BTA-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Bos taurus)
REACT:R-DRE-2090037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(6) (Danio rerio)
REACT:R-HSA-927813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
REACT:R-RNO-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Rattus norvegicus)
REACT:R-CFA-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Canis familiaris)
REACT:R-BTA-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Bos taurus)
REACT:R-BTA-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
REACT:R-BTA-199917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
REACT:R-BTA-6814764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasma membrane resorption (Bos taurus)
REACT:R-DRE-205328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other tyrosine kinases with p-KIT (Danio rerio)
RHEA:11268	skos:prefLabel	"D-cysteine desulfhydrase"
RHEA:11268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-cysteine desulfhydrase"
RHEA:11268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cysteine + H2O = H(+) + hydrogen sulfide + NH4(+) + pyruvate
RHEA:57752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
REACT:R-CFA-8940074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NMN (Canis familiaris)
REACT:R-DME-163320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of mTERF with the termination sequence (Drosophila melanogaster)
REACT:R-HSA-9645220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
REACT:R-GGA-9640237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Gallus gallus)
EC:3.4.21.91	skos:altLabel	"Yellow fever virus protease"
EC:3.4.21.91	skos:prefLabel	"flavivirin"
EC:3.4.21.91	skos:altLabel	"NS2B-3 proteinase"
EC:3.4.21.91	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavivirin"
RHEA:60454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H(+) + sulfite => 2-hydroxyethane-1-sulfonate
REACT:R-CEL-9607304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Caenorhabditis elegans)
RHEA:67810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine => L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine
REACT:R-MMU-921155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from the receptor complex (Mus musculus)
RHEA:61227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-asparagine + O2 <=> 2-oxosuccinamate + H2O2 + NH4(+)
REACT:R-GGA-372723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] <=> phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Gallus gallus)
REACT:R-DRE-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Danio rerio)
REACT:R-HSA-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)
REACT:R-XTR-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Xenopus tropicalis)
REACT:R-SSC-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Sus scrofa)
RHEA:34429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-pinoresinol + H(+) + NADPH => (-)-lariciresinol + NADP(+)
RHEA:39089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenedioyl-CoA + H2O2 => decanedioyl-CoA + O2
REACT:R-BTA-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Bos taurus)
REACT:R-HSA-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Homo sapiens)
REACT:R-RNO-6810594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)
RHEA:10959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) + NADPH + O2 <=> H2O + NADP(+) + trans-2-coumarate
REACT:R-SCE-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Saccharomyces cerevisiae)
REACT:R-DRE-111746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Danio rerio)
REACT:R-CFA-5578742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO1,2:small RNA complexes interact with chromatin (Canis familiaris)
RHEA:46674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydroaldosterone + NADP(+) => aldosterone + H(+) + NADPH
RHEA:22936	skos:prefLabel	"N-acetylglucosamine-6-phosphate deacetylase"
RHEA:22936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate
RHEA:22936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosamine-6-phosphate deacetylase"
RHEA:28186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetone + H2O + O2 = H2O2 + methylglyoxal + NH4(+)
RHEA:41483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + episterol <=> an episterol ester + CoA
RHEA:14604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + O2 <=> 5-aminopentanamide + CO2 + H2O
RHEA:43336	skos:altLabel	"carboxybiotin protein decarboxylase"
RHEA:43336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) = CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)
RHEA:43336	skos:prefLabel	"carboxybiotin decarboxylase"
RHEA:43336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxybiotin decarboxylase"
RHEA:21783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cyclohexanone <=> AH2 + cyclohex-2-enone
REACT:R-DRE-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Danio rerio)
REACT:R-MMU-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Mus musculus)
RHEA:28772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA => (9Z)-hexadecenoyl-CoA
REACT:R-XTR-5655142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 binds POLH (Xenopus tropicalis)
REACT:R-RNO-5654569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS2 (Rattus norvegicus)
RHEA:22938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + D-glucosamine 6-phosphate => H2O + N-acetyl-D-glucosamine 6-phosphate
RHEA:57787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite
RHEA:70399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-3-oxosphinganine
REACT:R-MMU-2453833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Mus musculus)
REACT:R-MMU-380311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Plk1 to centrosomes (Mus musculus)
RHEA:37264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-aspartate(out) => ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate
RHEA:20974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine
RHEA:55126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylhexanoyl-[ACP] + NAD(+) => (2E)-5-methylhexenoyl-[ACP] + H(+) + NADH
GO:0034529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity
REACT:R-SSC-5661117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Sus scrofa)
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NQO1
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-benzoquinone reductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced NAD(P)H dehydrogenase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD(P)H dehydrogenase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:(quinone-acceptor)oxidoreductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	QR1
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin-K reductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinone reductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DT-diaphorase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	menadione reductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H(2) dehydrogenase (quinone) activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavoprotein NAD(P)H-quinone reductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phylloquinone reductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	menadione oxidoreductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:quinone oxidoreductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADH-menadione reductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H2 dehydrogenase (quinone)
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	diaphorase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	viologen accepting pyridine nucleotide oxidoreductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD(P)H: menadione oxidoreductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H-quinone oxidoreductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin K reductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	azoreductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD(P)H menadione reductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	naphthoquinone reductase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)H dehydrogenase (quinone) activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity
GO:0003955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H-quinone dehydrogenase activity
REACT:R-BTA-159358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A3,4 dimers sulfate DA to DAOS (Bos taurus)
RHEA:24899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 GTP => 3',3'-c-di-GMP + 2 diphosphate
REACT:R-SCE-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Saccharomyces cerevisiae)
REACT:R-RNO-2032770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1 to the nucleus (Rattus norvegicus)
REACT:R-DRE-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Danio rerio)
RHEA:13132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-coumarate + UDP-alpha-D-glucose <=> 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP
REACT:R-DRE-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Danio rerio)
REACT:R-GGA-372719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
REACT:R-RNO-5696947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP47 deubiquitinates POLB (Rattus norvegicus)
RHEA:15582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biochanin A 7-O-beta-D-glucoside + malonyl-CoA => biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA
RHEA:66813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH => 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B
RHEA:58692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV = FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal
RHEA:19414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-phenylalanine + tRNA(Phe) => AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
RHEA:53810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Bos taurus)
REACT:R-CFA-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Canis familiaris)
REACT:R-HSA-1791092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DCTN1 (Homo sapiens)
REACT:R-DME-5252079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Drosophila melanogaster)
REACT:R-HSA-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Homo sapiens)
REACT:R-MMU-193736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)
REACT:R-XTR-1483089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is converted to PS by PTDSS2 (Xenopus tropicalis)
GO:0038117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CCL19 receptor activity
GO:0038117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-C motif chemokine 19 receptor activity
RHEA:66352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) = (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH
REACT:R-MMU-8983841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 associates with IL6ST:IL6ST (Mus musculus)
RHEA:43779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine(in) <=> an N-(acyl)-sphingosylphosphocholine(out)
REACT:R-HSA-9603797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:PEX3 binds PEX16 (Homo sapiens)
RHEA:25353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-cysteine + tRNA(Pro) => H2O + L-cysteinyl-tRNA(Pro)
RHEA:24108	skos:altLabel	"5-hydroxy-N-methylpyroglutamate synthase"
RHEA:24108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methyl-2-oxoglutaramate = 2-oxoglutarate + methylamine
RHEA:24108	skos:prefLabel	"N-methyl-2-oxoglutaramate hydrolase"
RHEA:24108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-methyl-2-oxoglutaramate hydrolase"
GO:0047684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:arylamine N-D-glucosyltransferase activity
GO:0047684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucose-arylamine glucosyltransferase activity
GO:0047684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:arylamine N-D-glucosyltransferase activity
GO:0047684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-arylamine glucosyltransferase activity
GO:0047684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylamine glucosyltransferase activity
RHEA:63784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine
RHEA:41278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-eicosanoyl-sphing-4-enine <=> eicosanoate + sphing-4-enine
RHEA:19675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) => 1,2,3-trihydroxybenzene + O2
RHEA:39357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH
REACT:R-XTR-2076611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3STs sulfate GlcN at C3 in heparan sulfate (Xenopus tropicalis)
REACT:R-RNO-8944263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type II (Rattus norvegicus)
RHEA:54536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate
REACT:R-DRE-139917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAX protein (Danio rerio)
REACT:R-HSA-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Homo sapiens)
REACT:R-HSA-9603982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeA to form LeB (Homo sapiens)
REACT:R-SSC-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)
RHEA:64122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + L-serine => an N-(fatty acyl)-L-serine + H2O
REACT:R-HSA-376123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM associates with Rac1-GTP:pPAK1 (Homo sapiens)
REACT:R-CFA-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
REACT:R-GGA-9703895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds CASR agonists (Gallus gallus)
RHEA:57057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apiofuranose + NAD(+) => D-apionolactone + H(+) + NADH
GO:0032843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroperoxide reductase activity
RHEA:46190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + NH4(+) => an aliphatic nitrile + 2 H2O
REACT:R-DRE-1470012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus (Danio rerio)
REACT:R-BTA-5682084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Bos taurus)
REACT:R-SSC-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Sus scrofa)
REACT:R-HSA-202724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-selectin binds P-selectin ligand (Homo sapiens)
REACT:R-BTA-5694421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6 dephosphorylates SEC24 (Bos taurus)
RHEA:19287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol => a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol
REACT:R-MMU-5617828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIP11:IFT20 dissociates (Mus musculus)
RHEA:24793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate
RHEA:24793	skos:altLabel	"IGP synthase"
RHEA:24793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"imidazole glycerol-phosphate synthase"
RHEA:24793	skos:prefLabel	"imidazole glycerol-phosphate synthase"
REACT:R-BTA-201640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Bos taurus)
REACT:R-CEL-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Caenorhabditis elegans)
RHEA:45914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH
RHEA:31437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-santalene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-XTR-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Xenopus tropicalis)
REACT:R-DDI-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Dictyostelium discoideum)
RHEA:44029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-altrarate => 5-dehydro-4-deoxy-D-glucarate + H2O
REACT:R-SPO-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Schizosaccharomyces pombe)
RHEA:62784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 fonsecin B + H(+) + NADPH + O2 = bifonsecin B + 2 H2O + NADP(+)
RHEA:64652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaraldehyde + CoA + NADP(+) = (E)-4-coumaroyl-CoA + H(+) + NADPH
REACT:R-GGA-8854981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 in the RET complex is phosphorylated (Gallus gallus)
REACT:R-BTA-4615900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB2 with SUMO3 (Bos taurus)
REACT:R-DME-5653974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator binds Rag dimers (Drosophila melanogaster)
RHEA:10357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5beta-androstan-17-one + NAD(+) => 5beta-androstane-3,17-dione + H(+) + NADH
RHEA:38117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol
RHEA:51636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + selenite = a quinol + selenate
REACT:R-HSA-9698008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)
REACT:R-PFA-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)
RHEA:61818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP => 16,17-didehydropregnenolone + UDP-alpha-D-glucose
REACT:R-HSA-9032751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Homo sapiens)
RHEA:46274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:68806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + D-glucose => H2O + kojibiose
RHEA:63514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2',3-triol + H2O + NAD(+) => biphenyl-2,2'-diol + H(+) + NADH + O2
REACT:R-MMU-2201341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TRAM (TICAM2) (Mus musculus)
GO:0005412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose:sodium symporter activity
GO:0005412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/glucose symporter activity
REACT:R-HSA-9011346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSI1 binds ROBO3.1 mRNA (Homo sapiens)
REACT:R-BTA-76472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ethylene is oxidized to Ethylene oxide by CYP1A1 (Bos taurus)
RHEA:31511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
GO:0030750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:putrescine N-methyltransferase activity
GO:0030750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine N-methyltransferase activity
GO:0030750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine methyltransferase activity
GO:0033989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
GO:0033989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity
GO:0033989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	46 kDa hydratase 2 activity
GO:0033989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity
GO:0033989	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-3-hydroxyacyl-CoA dehydratase activity
REACT:R-CFA-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Canis familiaris)
RHEA:31831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = delta-guaiene + diphosphate
RHEA:31831	skos:prefLabel	"delta-guaiene synthase"
RHEA:31831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"delta-guaiene synthase"
REACT:R-XTR-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Xenopus tropicalis)
REACT:R-SCE-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Saccharomyces cerevisiae)
RHEA:54435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate
REACT:R-HSA-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)
REACT:R-DRE-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Danio rerio)
REACT:R-SSC-8849350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Sus scrofa)
REACT:R-CEL-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
REACT:R-GGA-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Gallus gallus)
REACT:R-CFA-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)
RHEA:42973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a cardiolipin + ethanolamine
REACT:R-HSA-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Homo sapiens)
REACT:R-RNO-381612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1 (Rattus norvegicus)
REACT:R-SSC-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Sus scrofa)
RHEA:31340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + holo-[ACP] => acetyl-[ACP] + AMP + diphosphate
REACT:R-CEL-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Caenorhabditis elegans)
REACT:R-CFA-4332236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL neddylates TGFBR2 (Canis familiaris)
REACT:R-CFA-199050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Canis familiaris)
REACT:R-MMU-5661124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR4-HIST1H4 (Mus musculus)
RHEA:68405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-iso(homo)2citrate + NAD(+) => 2-oxoheptanedioate + CO2 + NADH
RHEA:46742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmosterol + NADP(+) => 7-dehydrodesmosterol + H(+) + NADPH
RHEA:59837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate
REACT:R-DRE-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Danio rerio)
REACT:R-DRE-5693346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CECRI deaminates Ade-Rib to Ino (Danio rerio)
REACT:R-DRE-5667008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds RHPN1 or RHPN2 (Danio rerio)
REACT:R-XTR-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:13162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADH
REACT:R-CFA-8851988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A2 binds T cell surface (Canis familiaris)
RHEA:64429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-proline(out) + H(+)(out) => glycyl-L-proline(in) + H(+)(in)
REACT:R-SSC-2396029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-3 binds integrins (Sus scrofa)
REACT:R-DRE-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Danio rerio)
REACT:R-MMU-5649800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Mus musculus)
REACT:R-DME-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Drosophila melanogaster)
REACT:R-CFA-9748979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Canis familiaris)
RHEA:24265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate + formaldehyde => D-glyceraldehyde 3-phosphate + dihydroxyacetone
REACT:R-SSC-109341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Sus scrofa)
RHEA:52975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]
RHEA:72592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate(out) + H(+)(out) => D-glucuronate(in) + H(+)(in)
RHEA:23045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-tyrosine => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O
RHEA:48734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O
RHEA:47632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine + NAD(+) = 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)
REACT:R-CFA-1614362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Canis familiaris)
REACT:R-SSC-9645520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Sus scrofa)
RHEA:70330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH
REACT:R-DRE-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Danio rerio)
REACT:R-SPO-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Schizosaccharomyces pombe)
REACT:R-HSA-3318571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MMADHC does not bind MMACHC:B12r (Homo sapiens)
REACT:R-HSA-9694723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoating of SARS-CoV-2 Genome (Homo sapiens)
REACT:R-RNO-5607733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 binds CARD9 (Rattus norvegicus)
RHEA:64383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + phytyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2
REACT:R-CFA-5617182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates PLN (Canis familiaris)
REACT:R-HSA-192832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of cRNA Synthesis (Homo sapiens)
RHEA:35860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-MMU-109699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
REACT:R-XTR-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Xenopus tropicalis)
RHEA:36592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-chloropropanoate + NADP(+) => 2-chloroacrylate + H(+) + NADPH
REACT:R-HSA-8875816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds activated MET receptor (Homo sapiens)
RHEA:36485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA
REACT:R-XTR-112437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NELF complex  (Xenopus tropicalis)
RHEA:32497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SPO-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Schizosaccharomyces pombe)
REACT:R-DME-209815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is monoiodinated (Drosophila melanogaster)
RHEA:71906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide
REACT:R-HSA-5623643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH13 reduces atRAL to atROL (Homo sapiens)
REACT:R-CFA-9701524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated downstream of active ALK (Canis familiaris)
REACT:R-SSC-9020255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Sus scrofa)
REACT:R-XTR-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Xenopus tropicalis)
REACT:R-HSA-5357828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8 (Homo sapiens)
REACT:R-BTA-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Bos taurus)
REACT:R-RNO-8934735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 arginine-methylates RUNX1 (Rattus norvegicus)
RHEA:34228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-nitrosalicylate + O2 => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite
REACT:R-SSC-1562641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)
REACT:R-CEL-9654523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP bind PDE6D on KRAS4B (Caenorhabditis elegans)
REACT:R-GGA-139898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 activates BID by cleavage (Gallus gallus)
REACT:R-MMU-5632652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds CDON and PTCH (Mus musculus)
REACT:R-DRE-8871260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD2 (Danio rerio)
REACT:R-DDI-211968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2W1 oxidises INDOL (Dictyostelium discoideum)
REACT:R-HSA-8877391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene (Homo sapiens)
REACT:R-CFA-70555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Canis familiaris)
GO:0102473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity
REACT:R-HSA-9695853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS (Homo sapiens)
REACT:R-PFA-5624951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNPO1 binds KIF17 dimer (Plasmodium falciparum)
REACT:R-MMU-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Mus musculus)
RHEA:59627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(4-aminobutanoyl)-L-ornithine <=> 4-aminobutanoate + L-ornithine
RHEA:46725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methyltetradecanoyl-CoA => (2R)-2-methyltetradecanoyl-CoA
REACT:R-SSC-9038161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Sus scrofa)
REACT:R-RNO-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Rattus norvegicus)
REACT:R-CEL-1449687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticosteroids bind to CBG in blood (Caenorhabditis elegans)
REACT:R-DME-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Drosophila melanogaster)
RHEA:53667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) <=> H(+) + 2 H2O + pyridinestrone carboxylate
RHEA:10468	skos:prefLabel	"phosphoketolase"
RHEA:10468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
RHEA:10468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoketolase"
RHEA:10468	skos:altLabel	"D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating)"
RHEA:10468	skos:altLabel	"xylulose-5-phosphate phosphoketolase"
RHEA:27793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-octaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)
REACT:R-MMU-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Mus musculus)
REACT:R-GGA-2022412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)
REACT:R-XTR-73815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)
RHEA:70217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH
RHEA:58223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + NAD(+) <=> H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide
RHEA:55232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O
RHEA:30805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + 2 H(+) + NADPH => 4-aminobutanal + H2O + NADP(+)
GO:0061712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase
REACT:R-RNO-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)
RHEA:51715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagatose 6-phosphate <=> keto-D-fructose 6-phosphate
RHEA:71679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-lysyl-glycine(out) = H(+)(in) + L-lysyl-glycine(in)
REACT:R-SPO-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Schizosaccharomyces pombe)
RHEA:35274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-DRE-8848758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates AKT1 (Danio rerio)
REACT:R-HSA-5623588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)
GO:0052722	skos:altLabel	"CYP703A2"
GO:0052722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"laurate 7-monooxygenase"
GO:0052722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid in-chain hydroxylase activity
GO:0052722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0052722	skos:prefLabel	"laurate 7-monooxygenase"
REACT:R-HSA-9037612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H antigen-sec translocates from Golgi lumen to extracellular region (Homo sapiens)
REACT:R-SSC-170846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 recruits TGFBR1 (Sus scrofa)
RHEA:64698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H(+) + NADH => benzyl alcohol + NAD(+)
REACT:R-MMU-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Mus musculus)
REACT:R-SPO-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Schizosaccharomyces pombe)
REACT:R-SSC-8848215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Sus scrofa)
REACT:R-RNO-376364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp8 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)
RHEA:35832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + kanamycin B + O2 => 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate
REACT:R-SSC-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Sus scrofa)
RHEA:55532	skos:prefLabel	"phenylacetaldehyde synthase"
RHEA:55532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-phenylalanine + O2 = 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)
RHEA:55532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetaldehyde synthase"
REACT:R-BTA-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Bos taurus)
RHEA:62010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose
RHEA:54855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptan-4-one + NADPH + O2 <=> H2O + NADP(+) + propyl butanoate
REACT:R-CFA-198599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MDM2 (Canis familiaris)
REACT:R-RNO-382055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb7 binds to the active PDGF receptor (Rattus norvegicus)
REACT:R-GGA-8865774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLLs polyglutamylate tubulin (Gallus gallus)
REACT:R-DRE-428231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Danio rerio)
REACT:R-GGA-877281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 binds p-STAT1 dimer (Gallus gallus)
REACT:R-MMU-8952996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 forms homodimers (Mus musculus)
RHEA:51551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-tetrahydropapaverine + S-adenosyl-L-methionine <=> (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-5635843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI translocates to the nucleus (Drosophila melanogaster)
REACT:R-SPO-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Schizosaccharomyces pombe)
REACT:R-SSC-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Sus scrofa)
REACT:R-HSA-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Homo sapiens)
RHEA:53630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate => (2E,6E)-farnesyl diphosphate
EC:3.4.1.-	skos:prefLabel	"alpha-Amino-acyl-peptide hydrolases"
EC:3.4.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-Amino-acyl-peptide hydrolases"
REACT:R-SSC-5635860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Sus scrofa)
RHEA:56903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP
REACT:R-CFA-9755304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUL1 ubiquitinates UBXN7 (Canis familiaris)
RHEA:43666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + tetracosanoyl-CoA
REACT:R-CFA-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Canis familiaris)
GO:0015207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Homo sapiens)
GO:0015207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine transmembrane transporter activity
RHEA:45283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-(phosphooxy)octadecanoate + H2O <=> 12-hydroxyoctadecanoate + phosphate
REACT:R-SSC-69685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TP53 (Sus scrofa)
REACT:R-CEL-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Caenorhabditis elegans)
RHEA:37980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine => 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine
GO:0102778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta9-tetrahydrocannabinolate synthase activity
REACT:R-RNO-1168638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated IKK phosphorylates I-kappaB (Rattus norvegicus)
REACT:R-CFA-8851011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 polyubiquitinates PTEN (Canis familiaris)
RHEA:11710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + XMP => H2O + IMP + NAD(+)
RHEA:42612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)
RHEA:24449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin + UDP-alpha-D-glucose => monoglucosyl-enterobactin + UDP
REACT:R-DDI-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Dictyostelium discoideum)
RHEA:67298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2 => (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2
REACT:R-SSC-2172126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAP12 interacts with NKG2C (Sus scrofa)
REACT:R-BTA-9701485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds JAK3 (Bos taurus)
REACT:R-BTA-3076905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular BTD hydrolyses BCTN (Bos taurus)
REACT:R-DRE-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Danio rerio)
REACT:R-HSA-8937682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds SRC (Homo sapiens)
REACT:R-XTR-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Xenopus tropicalis)
RHEA:53038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate
RHEA:28272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(8)-acetylspermidine => acetyl-CoA + spermidine
RHEA:34182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mycophenolic acid O-acyl-beta-D-glucuronide <=> D-glucuronate + H(+) + mycophenolate
REACT:R-CFA-8863494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASICs bind STOML3, (STOM) (Canis familiaris)
REACT:R-DME-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Drosophila melanogaster)
GO:0032131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylated DNA binding
REACT:R-MMU-8857928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIHBP1 binds HSPG:LPL dimer (Mus musculus)
REACT:R-CFA-217255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO1:FAD N-oxidises TAM (Canis familiaris)
REACT:R-MMU-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Mus musculus)
RHEA:39404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)
RHEA:30603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + A = AH2 + all-trans-phytofluene
REACT:R-BTA-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Bos taurus)
RHEA:62267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) <=> hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)
REACT:R-SSC-879914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3 stimulation induces Vav binding to Tec kinase (Sus scrofa)
REACT:R-DRE-9032751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Danio rerio)
REACT:R-DME-5654651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS3 (Drosophila melanogaster)
RHEA:66239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IC-asc-C9-CoA + O2 <=> H2O2 + IC-asc-DeltaC9-CoA
REACT:R-BTA-5693742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH hydrolyses AEA to AA and ETA (Bos taurus)
RHEA:37360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucosamine 6-phosphate(in) + L-histidyl-[protein]
REACT:R-CEL-209859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decarboxylation of 5-hydroxytryptophan forms serotonin (Caenorhabditis elegans)
REACT:R-SSC-6806674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Sus scrofa)
GO:0034863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,4-trimethyl-1-pentanol dehydrogenase activity
REACT:R-BTA-8850831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates KLK8 (Bos taurus)
EC:1.14.14.108	skos:altLabel	"camphor 1,2-monooxygenase"
EC:1.14.14.108	skos:altLabel	"2,5-diketocamphane lactonizing enzyme"
EC:1.14.14.108	skos:prefLabel	"2,5-diketocamphane 1,2-monooxygenase"
EC:1.14.14.108	skos:altLabel	"camphor ketolactonase I"
EC:1.14.14.108	skos:altLabel	"2,5-diketocamphane 1,2-monooxygenase oxygenating component"
EC:1.14.14.108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,5-diketocamphane 1,2-monooxygenase"
GO:0050490	skos:altLabel	"gamma-lactonase"
GO:0050490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-lactonase activity
GO:0050490	skos:prefLabel	"1,4-lactonase"
GO:0050490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,4-lactone + H2O = a 4-hydroxyacid + H(+)
GO:0050490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,4-lactonase"
GO:0050490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-lactonase activity
GO:0050490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-lactone hydroxyacylhydrolase activity
REACT:R-CEL-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Caenorhabditis elegans)
REACT:R-DRE-5691154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HFE binds TFRC dimer (Danio rerio)
REACT:R-RNO-5654409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS2 (Rattus norvegicus)
RHEA:45140	skos:altLabel	"gamma-glutamyl carboxylase"
RHEA:45140	skos:altLabel	"vitamin K-dependent carboxylase"
RHEA:45140	skos:prefLabel	"peptidyl-glutamate 4-carboxylase"
RHEA:45140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O = CO2 + L-glutamyl-[protein] + O2 + phylloquinol
RHEA:45140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidyl-glutamate 4-carboxylase"
REACT:R-CFA-8875320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 GEFs exchange GTP for GDP on RAB5 (Canis familiaris)
REACT:R-CEL-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)
REACT:R-MMU-1475022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (cytosol) (Mus musculus)
RHEA:21821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + S-adenosyl-L-methionine => H(+) + L-methionine + S-adenosyl-L-homocysteine
RHEA:15084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + CoA <=> acetyl-CoA + ADP + phosphate
GO:0140566	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	epigenetic reader
GO:0140566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone reader activity
GO:0140566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone reader
REACT:R-BTA-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Bos taurus)
REACT:R-GGA-4420121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate PLCG1 (Gallus gallus)
RHEA:12656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NAD(+) <=> CO2 + NADH + pyruvate
REACT:R-HSA-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Homo sapiens)
RHEA:53960	skos:prefLabel	"4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase"
RHEA:53960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O
RHEA:53960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase"
GO:0004013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylhomocysteinase activity
GO:0004013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SAHase activity
GO:0004013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylhomocysteinase activity
GO:0004013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylhomocysteine synthase activity
GO:0004013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-homocysteine hydrolase activity
GO:0004013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AdoHcyase activity
GO:0004013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylhomocysteine hydrolase activity
GO:0004013	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	S-adenosylhomocysteine hydrolase activity
GO:0102175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity
REACT:R-DRE-5621354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Danio rerio)
REACT:R-SCE-71286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Saccharomyces cerevisiae)
REACT:R-MMU-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Mus musculus)
RHEA:22808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-hydroxynicotinate dehydrogenase"
RHEA:22808	skos:altLabel	"6-hydroxynicotinate hydroxylase"
RHEA:22808	skos:altLabel	"6-hydroxynicotinic acid hydroxylase"
RHEA:22808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2
RHEA:22808	skos:altLabel	"6-hydroxynicotinic acid dehydrogenase"
RHEA:22808	skos:prefLabel	"6-hydroxynicotinate dehydrogenase"
RHEA:10414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + D-ribose 5-phosphate + 2 H(+) => ADP-D-ribose + H2O
RHEA:59059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 methanethiol + NAD(+) <=> dimethyl disulfide + H(+) + NADH
REACT:R-CFA-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Canis familiaris)
RHEA:31772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an all-trans-retinyl ester + H2O => 11-cis-retinol + a fatty acid + H(+)
REACT:R-DRE-917744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA loaded synaptic vesicle Docking and Priming (Danio rerio)
REACT:R-CFA-71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)
REACT:R-RNO-446694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 phosphorylates IRAK1 (Rattus norvegicus)
RHEA:56714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein]
RHEA:44081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + undecanoate => AMP + diphosphate + undecanoyl-CoA
REACT:R-DME-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Drosophila melanogaster)
REACT:R-CFA-202731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM3 dimerises (Canis familiaris)
REACT:R-HSA-168848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAK protein (Homo sapiens)
RHEA:58111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[protein] <=> acetate + L-lysyl-[protein]
REACT:R-XTR-389523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTLA interacts with HVEM (Xenopus tropicalis)
REACT:R-CFA-6803719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds ZNF385A (Canis familiaris)
REACT:R-MMU-8858428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FCAMR binds IgA (Mus musculus)
RHEA:31362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + nitrilotriacetate + O2 <=> ammoniodiacetate + FMN + glyoxylate + H2O
GO:0004080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity
GO:0004080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-propionyl coenzyme A carboxylase synthetase activity
GO:0004080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity
GO:0004080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
GO:0004080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity
GO:0004080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	holocarboxylase synthetase activity
GO:0004080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionyl-CoA holocarboxylase synthetase activity
GO:0004080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionyl coenzyme A holocarboxylase synthetase activity
GO:0004080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
RHEA:38027	skos:prefLabel	"caffeate CoA-transferase"
RHEA:38027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + hydrocaffeoyl-CoA = (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate
RHEA:38027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caffeate CoA-transferase"
REACT:R-BTA-1306953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
REACT:R-DRE-5624951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNPO1 binds KIF17 dimer (Danio rerio)
REACT:R-DRE-8848005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 promotes PTK6 autophosphorylation (Danio rerio)
RHEA:32638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-195408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Rattus norvegicus)
REACT:R-PFA-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Plasmodium falciparum)
RHEA:20754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 2 aquacob(III)alamin => A + 2 cob(II)alamin + 2 H(+) + 2 H2O
RHEA:51786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyhumulone + diphosphate => 4-prenylphlorisovalerophenone + dimethylallyl diphosphate
RHEA:65529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + octanoyl-CoA => CoA + hexyl octanoate
RHEA:44529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)
RHEA:38025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol => gamma-tocotrienol
GO:0031963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear cortisol receptor activity
GO:0031963	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cortisol receptor activity
RHEA:66661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-glucosylceramide(in) + H2O => ADP + beta-D-glucosylceramide(out) + H(+) + phosphate
REACT:R-SSC-110364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Sus scrofa)
REACT:R-DRE-192056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Danio rerio)
REACT:R-SSC-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Sus scrofa)
RHEA:36826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol <=> CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate
REACT:R-SSC-9708104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE5A dimer binds PDE5A inhibitors (Sus scrofa)
RHEA:63867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octadecanoate <=> (2R)-2-hydroperoxyoctadecanoate
REACT:R-HSA-5601919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown nuclease cleaves cleaved transposon RNA bound in MeR-PIWIL4:cleaved transposon RNA:TDRD9:MAEL:TDRKH (Homo sapiens)
REACT:R-GGA-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Gallus gallus)
RHEA:34684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O => alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)
REACT:R-RNO-5607741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p52:RELB translocates from cytosol to nucleus (Rattus norvegicus)
RHEA:12126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + trans-4-coumaroylshikimate => 4-coumaroyl-CoA + shikimate
RHEA:69954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-8856808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of AP-2 complex and clathrin (Rattus norvegicus)
REACT:R-BTA-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Bos taurus)
REACT:R-CFA-6807064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces ZYMOL to ZYMSTNL (Canis familiaris)
RHEA:67122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine
RHEA:19188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + propanoyl-CoA <=> 2-hydroxyglutarate + CoA + H(+)
REACT:R-GGA-9021306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds and inactivates C1r, C1s (Gallus gallus)
REACT:R-MMU-205118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 polyubiquitinates NRIF (Mus musculus)
REACT:R-HSA-1306963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)
REACT:R-CFA-2294600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates condensin II subunit NCAPD3 (Canis familiaris)
RHEA:20061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+)
RHEA:15606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine O-sulfate => H(+) + NH4(+) + pyruvate + sulfate
RHEA:50177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate
REACT:R-CEL-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Caenorhabditis elegans)
EC:3.6.4.10	skos:altLabel	"molecular chaperone Hsc70 ATPase"
EC:3.6.4.10	skos:prefLabel	"non-chaperonin molecular chaperone ATPase"
EC:3.6.4.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"non-chaperonin molecular chaperone ATPase"
REACT:R-BTA-888614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO2 dioxygenates L-Trp to NFK (Bos taurus)
REACT:R-SSC-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Sus scrofa)
REACT:R-DME-428510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Drosophila melanogaster)
RHEA:18217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an alkane-alpha,omega-diamine = an omega-aminoaldehyde + L-glutamate
RHEA:18217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diamine transaminase"
RHEA:18217	skos:altLabel	"diamine aminotransferase"
RHEA:18217	skos:prefLabel	"diamine transaminase"
REACT:R-HSA-2022383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
REACT:R-CFA-5672980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF complex (Canis familiaris)
RHEA:67278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexanoate + NADH => H2O + hexanal + NAD(+)
GO:0015217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP transmembrane transporter activity
REACT:R-CFA-8857549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HBEGF-bound EGFR forms a heterodimer with GPNMB (Canis familiaris)
GO:0033835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity
GO:0033835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1->2 UDP-rhamnosyltransferase activity
GO:0033835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity
GO:0033835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity
REACT:R-HSA-203901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II mediated transcription of microRNA genes (Homo sapiens)
REACT:R-HSA-113451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of RNA Polymerase III Productive Transcription (Homo sapiens)
REACT:R-GGA-5669013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA-3 binds EDA2R (Gallus gallus)
REACT:R-RNO-5591086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA5 binds activated protein C (Rattus norvegicus)
REACT:R-DRE-8964284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in active Gq-BTK complex is activated (Danio rerio)
REACT:R-HSA-5604975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)
REACT:R-DRE-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Danio rerio)
REACT:R-DME-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Drosophila melanogaster)
RHEA:63270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2
REACT:R-HSA-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)
RHEA:35951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate = diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
RHEA:35951	skos:prefLabel	"7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase"
RHEA:35951	skos:altLabel	"dihydropteroate synthase"
RHEA:35951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase"
REACT:R-CFA-198315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)
RHEA:61345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine + O2 => 3-hydroxypyruvate + H2O2 + NH4(+)
RHEA:52034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-7-isojasmonate + L-isoleucine => H2O + L-isoleucine-(+)-7-isojasmonate
REACT:R-XTR-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Xenopus tropicalis)
REACT:R-MMU-2395872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)
RHEA:32715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-methylmalate + NAD(+) = 2-oxobutanoate + CO2 + NADH
RHEA:32715	skos:prefLabel	"3-methylmalate dehydrogenase"
RHEA:32715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-methylmalate dehydrogenase"
GO:0102037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrotoluene monooxygenase activity
REACT:R-HSA-180555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of APOBEC3G:Vif with the Cul5-SCF complex (Homo sapiens)
RHEA:21866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxy carboxylate + glutathione + H(+) => an S-(2-hydroxyacyl)glutathione + H2O
RHEA:48573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dichlorocatechol + O2 => (2E,4E)-2,4-dichloromuconate + 2 H(+)
RHEA:43169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(34) in tRNA + H(+) + H2O => inosine(34) in tRNA + NH4(+)
REACT:R-XTR-388833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CTLA-4 (Xenopus tropicalis)
RHEA:24996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Drosophila melanogaster)
RHEA:11589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + isoquinoline => AH2 + isoquinolin-1(2H)-one
RHEA:48215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine
REACT:R-MMU-109278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Mus musculus)
RHEA:28624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol
RHEA:18380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin <=> ADP + H(+) + streptomycin 3''-phosphate
REACT:R-HSA-374331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estrogen sulfokinase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol sulfokinase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxysteroid sulfotransferase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	estrogen sulfotransferase
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol sulphotransferase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxysteroid sulfotransferase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta5-3beta-hydroxysteroid sulfokinase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HST
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid alcohol sulfotransferase
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol sulfotransferase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol sulfotransferase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydroepiandrosterone sulfotransferase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy steroid sulfotransferase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid sulfokinase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alcohol/hydroxysteroid sulfotransferase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxysteroid sulfotransferase activity
GO:0004027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5alpha-androstenol sulfotransferase activity
RHEA:43654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-[ACP] + CO2 + CoA => decanoyl-CoA + H(+) + malonyl-[ACP]
REACT:R-DME-432590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PER is phosphorylated by CK2 (Drosophila melanogaster)
RHEA:49069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]
RHEA:29195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + a menaquinone = a menaquinol + orotate
RHEA:20414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine => glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine
RHEA:39640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O
REACT:R-GGA-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Gallus gallus)
RHEA:36933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2
REACT:R-RNO-937337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Rattus norvegicus)
RHEA:54227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin H2)-sn-glycero-3-phosphocholine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphocholine
RHEA:42859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate
RHEA:54170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine
REACT:R-DRE-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Danio rerio)
REACT:R-CFA-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Canis familiaris)
REACT:R-HSA-167111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex (Homo sapiens)
REACT:R-HSA-5633460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds TP53 (Homo sapiens)
RHEA:41530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADH
RHEA:53955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate <=> 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate
EC:2.3.1.74	skos:altLabel	"6'-deoxychalcone synthase"
EC:2.3.1.74	skos:altLabel	"flavonone synthase"
EC:2.3.1.74	skos:altLabel	"naringenin-chalcone synthase"
EC:2.3.1.74	skos:prefLabel	"chalcone synthase"
EC:2.3.1.74	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chalcone synthase"
RHEA:68184	skos:prefLabel	"ADP-dependent medium-chain-acyl-CoA hydrolase"
RHEA:68184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty acyl-CoA + H2O = a medium chain fatty acid + CoA + H(+)
RHEA:68184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-dependent medium-chain-acyl-CoA hydrolase"
REACT:R-SCE-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Saccharomyces cerevisiae)
REACT:R-HSA-5696813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSEN complex cleaves the intron from pre-tRNA (Homo sapiens)
GO:0099077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-dependent DNA binding
REACT:R-SSC-159771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein C to protein C (Sus scrofa)
RHEA:42374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine => 16-methoxytabersonine + H2O
REACT:R-MMU-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)
RHEA:41962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 (d18:1(4E)) + H(+) + UDP => ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose
GO:0052905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (guanine(9)-N(1))-methyltransferase activity
GO:0052905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA m(1)G(9) Mtase activity
GO:0052905	skos:altLabel	"tRNA m(1)G(9)-methyltransferase"
GO:0052905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine
GO:0052905	skos:altLabel	"tRNA m(1)G(9) MTase"
GO:0052905	skos:prefLabel	"tRNA (guanine(9)-N(1))-methyltransferase"
GO:0052905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (guanine(9)-N(1))-methyltransferase"
GO:0052905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity
GO:0052905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA (guanine-N(1)-)-methyltransferase activity
GO:0052905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA m(1)G(9)-methyltransferase activity
GO:0052905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA(m(1)G(9)/m(1)A(9))Mtase activity
GO:0016627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-CH group of donors
GO:0016627	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on the CH-CH group of donors, other acceptors
RHEA:28689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orotate + ubiquinol-8 => (S)-dihydroorotate + ubiquinone-8
REACT:R-CFA-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Canis familiaris)
REACT:R-MMU-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Mus musculus)
REACT:R-HSA-5659998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P (Homo sapiens)
REACT:R-HSA-5682965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Homo sapiens)
REACT:R-CFA-8948832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 polyubiquitinates PARylated PTEN (Canis familiaris)
GO:0102393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[acp] 2-dehydrogenase activity
REACT:R-BTA-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Bos taurus)
REACT:R-HSA-6806417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the DDB2 gene (Homo sapiens)
RHEA:16064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 3-phosphocholine <=> choline + H(+) + sn-glycerol 3-phosphate
REACT:R-DRE-177479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Axonal transport of NGF:Trk complexes (Danio rerio)
GO:0015187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine transmembrane transporter activity
GO:0015187	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycine betaine/proline porter activity
GO:0015187	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycine transporter activity
GO:0015187	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proline/glycine/betaine:hydrogen/sodium symporter activity
REACT:R-CFA-8852351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 promotes translocation of TP53 to the cytosol (Canis familiaris)
REACT:R-GGA-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Gallus gallus)
REACT:R-SSC-174959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT1 (Sus scrofa)
GO:0102943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity
RHEA:59374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+) => 1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O
RHEA:39836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + phosphate
RHEA:35666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)
REACT:R-MMU-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Mus musculus)
REACT:R-HSA-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Homo sapiens)
REACT:R-XTR-2584246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT1-GTP hydrolyses its bound GTP to GDP (Xenopus tropicalis)
RHEA:25377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-methyl-branched fatty aldehyde + formyl-CoA => a 2-hydroxy-3-methyl fatty acyl-CoA
RHEA:25967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-benzoin + NADP(+) <=> benzil + H(+) + NADPH
RHEA:61278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-ornithine + O2
REACT:R-BTA-203070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of profilin with monomeric actin (Bos taurus)
REACT:R-DRE-6789072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP1 binds bacterial peptidoglycan (Danio rerio)
REACT:R-SSC-9749505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC14 binds IKBKB and CHUK (Sus scrofa)
RHEA:15961	skos:prefLabel	"hydroxymandelonitrile glucosyltransferase"
RHEA:15961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxymandelonitrile glucosyltransferase"
RHEA:15961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxymandelonitrile + UDP-alpha-D-glucose = H(+) + taxiphyllin + UDP
RHEA:15961	skos:altLabel	"cyanohydrin glucosyltransferase"
RHEA:63585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxyecdysone 22-phosphate + H2O => 2-deoxyecdysone + phosphate
GO:0003873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-fructose-6-phosphate 2-phosphotransferase activity
GO:0003873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 6-phosphate 2-kinase activity
GO:0003873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphofructokinase 2 activity
GO:0003873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphofructose 2-kinase activity
GO:0003873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phosphofructo-2-kinase activity
GO:0003873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity
GO:0003873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphofructo-2-kinase (phosphorylating)
REACT:R-DDI-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Dictyostelium discoideum)
REACT:R-GGA-2981040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC12:ligand is endocytosed (Gallus gallus)
RHEA:24257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + kanamycin A => ADP + H(+) + kanamycin 3'-phosphate
REACT:R-CFA-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Canis familiaris)
REACT:R-XTR-417896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y6 receptor can bind to UDP (Xenopus tropicalis)
RHEA:40014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O <=> diphosphate + manool
REACT:R-HSA-9694419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)
REACT:R-DME-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Drosophila melanogaster)
RHEA:23373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
RHEA:66793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-D-dopa + O2 => (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2
REACT:R-DRE-1602446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Danio rerio)
RHEA:42012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH
REACT:R-CEL-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Caenorhabditis elegans)
RHEA:16311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + taurine => H2O + taurochenodeoxycholate
REACT:R-DRE-265296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Danio rerio)
REACT:R-SPO-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Schizosaccharomyces pombe)
RHEA:25032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-beta-D-ribose 1''-phosphate + H2O <=> ADP-D-ribose + phosphate
REACT:R-DME-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Drosophila melanogaster)
REACT:R-HSA-3238999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)
REACT:R-DRE-8983003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Danio rerio)
REACT:R-DME-8964340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq-BTK complex dissociates to Active BTK and Gq (Drosophila melanogaster)
REACT:R-MMU-376200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A10-mediated uptake of small neutral amino acids (Mus musculus)
REACT:R-RNO-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Rattus norvegicus)
REACT:R-DRE-204871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb2 (Danio rerio)
RHEA:53890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + H(+) + TDP => D-glucose 6-phosphate + TDP-alpha-D-glucose
REACT:R-MMU-9613570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Mus musculus)
RHEA:72909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(in) + Na(+)(in) => D-mannose(out) + Na(+)(out)
RHEA:66716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate
REACT:R-BTA-4341072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RARA with SUMO2 (Bos taurus)
REACT:R-RNO-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Rattus norvegicus)
REACT:R-BTA-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Bos taurus)
REACT:R-RNO-176879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein(a) + LDL => Lp(a) (Rattus norvegicus)
RHEA:44947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-3-acyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + a fatty acid + H(+)
RHEA:52749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-isomaltosyl-(1->3)-isomaltose + H2O => 2 isomaltose
REACT:R-RNO-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Rattus norvegicus)
REACT:R-GGA-3968414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Gallus gallus)
REACT:R-MMU-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Mus musculus)
RHEA:48434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => ATP + N(6)-D-ribulosyl-L-lysyl-[protein]
REACT:R-HSA-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Homo sapiens)
REACT:R-CFA-8865613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Canis familiaris)
RHEA:33122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-sativene + diphosphate
REACT:R-MMU-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Mus musculus)
RHEA:63284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-SPO-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Schizosaccharomyces pombe)
REACT:R-RNO-139920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tBID to mitochondria (Rattus norvegicus)
REACT:R-DME-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Drosophila melanogaster)
RHEA:38317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + pyruvate => chorismate
RHEA:45766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-aspartate + NADH => H2O + L-aspartate 4-semialdehyde + NAD(+)
REACT:R-DRE-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Danio rerio)
REACT:R-MMU-5654605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS3 (Mus musculus)
REACT:R-SSC-9014467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the ER membrane (Sus scrofa)
RHEA:68804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kojibiose = alpha-D-glucose + D-glucose
RHEA:19031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 2 NH4(+) => 3 H(+) + H2O + urea-1-carboxylate
REACT:R-DME-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Drosophila melanogaster)
RHEA:33203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:58863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SCE-1482892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Saccharomyces cerevisiae)
RHEA:39263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH = (13Z)-docosenoyl-CoA + NADP(+)
REACT:R-RNO-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
REACT:R-DRE-8984012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Danio rerio)
RHEA:64632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + butan-1-ol = butyl acetate + CoA
GO:0016720	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	crepenynate synthase activity
GO:0016720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)
GO:0016720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta12-fatty acid dehydrogenase activity
GO:0016720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta12 fatty acid acetylenase activity
GO:0016720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D12-fatty acid dehydrogenase activity
GO:0016720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleate delta-12-fatty acid acetylenase (desaturase) activity
GO:0016720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate delta12-fatty acid acetylenase (desaturase)
GO:0016720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-12 fatty acid acetylenase activity
REACT:R-RNO-6787321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DERA cleaves dR5P to GA3P and CH3CHO (Rattus norvegicus)
RHEA:42297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]
RHEA:70518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:12992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + H2O <=> a dolichyl phosphate + D-mannose + H(+)
REACT:R-SSC-1454781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Sus scrofa)
REACT:R-MMU-6799202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Mus musculus)
REACT:R-DRE-374664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of Ezrin (Danio rerio)
REACT:R-SPO-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Schizosaccharomyces pombe)
REACT:R-XTR-349404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Xenopus tropicalis)
GO:0050147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside:purine(pyrimidine) D-ribosyltransferase activity
GO:0050147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside ribosyltransferase activity
GO:0050147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside N-ribosyltransferase activity
RHEA:39629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA
RHEA:29691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltotetraose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotriose
REACT:R-MMU-159868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor VII to factor VII (Mus musculus)
REACT:R-HSA-158278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Homo sapiens)
REACT:R-CFA-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Canis familiaris)
REACT:R-SSC-9759549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Sus scrofa)
RHEA:40456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA
RHEA:16105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O
GO:0140682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity
GO:0140682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase"
GO:0140682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD-dependent H3K4me/H3K4me3 demethylase activity
GO:0140682	skos:altLabel	"lysine-specific histone demethylase 1"
GO:0140682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]
GO:0140682	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K4me2 demethylase activity
GO:0140682	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H3K4me demethylase activity
GO:0140682	skos:prefLabel	"[histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase"
REACT:R-GGA-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Gallus gallus)
RHEA:69229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkenimidothioate => an epithionitrile + sulfate
REACT:R-XTR-8865994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds PTPN11 (Xenopus tropicalis)
REACT:R-SSC-3238999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Sus scrofa)
GO:0005291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity L-histidine transmembrane transporter activity
GO:0005291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity L-histidine transmembrane transporter activity
GO:0005291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	high affinity histidine permease activity
REACT:R-XTR-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Xenopus tropicalis)
RHEA:24320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine
RHEA:12753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol 2-dehydrogenase (NADP(+))"
RHEA:12753	skos:altLabel	"dihydroxyacetone reductase"
RHEA:12753	skos:prefLabel	"glycerol 2-dehydrogenase (NADP(+))"
RHEA:12753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NADP(+) = dihydroxyacetone + H(+) + NADPH
RHEA:60709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemal + H2O + NAD(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADH
REACT:R-CEL-71324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)
REACT:R-DME-77327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Drosophila melanogaster)
REACT:R-DME-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Drosophila melanogaster)
RHEA:65935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine <=> 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Homo sapiens)
RHEA:42249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + CoA
GO:0102638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity
GO:0004817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteinyl-transfer ribonucleate synthetase activity
GO:0004817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine:tRNACys ligase (AMP-forming)
GO:0004817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine translase activity
GO:0004817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteinyl-tRNA synthetase activity
GO:0004817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteinyl-transferRNA synthetase activity
GO:0004817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-tRNA ligase activity
RHEA:15092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + A <=> AH2 + pyruvate
REACT:R-HSA-5362448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)
GO:0140941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K20me methyltransferase activity
GO:0140941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4 methyl lysine(20) N-methyltransferase activity (H4-K20 specific)
GO:0140941	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H4K20 dimethylation
GO:0140941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K20me methylase activity
GO:0140941	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H4-K20 dimethylation
REACT:R-RNO-420586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Necl-2 trans heterodimer interaction (Rattus norvegicus)
REACT:R-MMU-1251997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ERBB4m80 by gamma-scretase complex (Mus musculus)
REACT:R-BTA-9629216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Bos taurus)
RHEA:13728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-D-glucosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate
RHEA:69077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline + H2O + O2 => (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)
REACT:R-CFA-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Canis familiaris)
REACT:R-HSA-9711058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 nsp3 deubiquinates K48-linked pUb IkBA (Homo sapiens)
RHEA:15523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetradecanoylglycyl-[protein] => N-terminal glycyl-[protein] + tetradecanoyl-CoA
RHEA:69670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + luteolin 4'-O-beta-D-glucoside <=> beta-D-glucose + luteolin
RHEA:69445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => alpha-cadinene + diphosphate
GO:0035643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-DOPA receptor activity
GO:0035643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-beta-(3,4-Dihydroxyphenyl)alanine receptor activity
REACT:R-SSC-5638333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)
RHEA:49301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]
REACT:R-BTA-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Bos taurus)
REACT:R-BTA-1022129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Bos taurus)
REACT:R-DRE-5651723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Danio rerio)
REACT:R-HSA-1604722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP9 by proteases (Homo sapiens)
RHEA:45051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetamide + H2O <=> acetate + NH4(+)
REACT:R-DME-201445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Drosophila melanogaster)
GO:0045436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lycopene beta cyclase activity
GO:0045436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	crtL
GO:0045436	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lycopene cyclase
GO:0047311	skos:prefLabel	"1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase"
GO:0047311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity
GO:0047311	skos:altLabel	"1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase"
GO:0047311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity
GO:0047311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity
GO:0047311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase"
GO:0047311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity
GO:0047311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity
GO:0047311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine
REACT:R-MMU-8851018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A1 binds DC-SIGN (Mus musculus)
REACT:R-HSA-8865774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLLs polyglutamylate tubulin (Homo sapiens)
RHEA:47779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:35696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-versiconol acetate + NADP(+) => (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH
RHEA:11605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA
REACT:R-HSA-8936519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO2:FAD dimer reduces quinones to hydroquinones (Homo sapiens)
GO:0047420	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-D-amino acid amidohydrolase activity
GO:0047420	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aminoacylase activity
GO:0047420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl-D-amino-acid deacylase activity
REACT:R-BTA-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Bos taurus)
REACT:R-DRE-140686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Danio rerio)
REACT:R-HSA-8938507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-106a binds RUNX1 mRNA (Homo sapiens)
GO:0106017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,4-bisphosphate phosphatase activity
RHEA:52088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
RHEA:49884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-888614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO2 dioxygenates L-Trp to NFK (Rattus norvegicus)
RHEA:27271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanal + NADP(+) => H(+) + hexadecanoyl-CoA + NADPH
REACT:R-GGA-159733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor X to factor X (Gallus gallus)
REACT:R-RNO-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Rattus norvegicus)
REACT:R-CEL-1482887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)
REACT:R-HSA-2562526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates OPTN (Homo sapiens)
RHEA:31453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin + glycerol => 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-CFA-419389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA-binding receptors bind LPA (Canis familiaris)
RHEA:21850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide
RHEA:38959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2
RHEA:38959	skos:prefLabel	"acyl-CoA oxidase"
RHEA:38959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA oxidase"
RHEA:16144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + NAD(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADH
REACT:R-MMU-75244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL binds FAS Receptor (Mus musculus)
RHEA:18746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 juglone + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)
RHEA:21579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine + H(+) <=> 2-methylcholine + CO2
REACT:R-GGA-8852509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL-LK binds carbohydrates on target cell surface (Gallus gallus)
REACT:R-DME-8952128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TP53 (Drosophila melanogaster)
RHEA:23723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + propanoyl-CoA <=> (S)-methylmalonyl-CoA + ADP + H(+) + phosphate
REACT:R-GGA-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Gallus gallus)
REACT:R-MMU-9731613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)
RHEA:44306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA
RHEA:40946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate
REACT:R-HSA-4615905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO1 (Homo sapiens)
REACT:R-XTR-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Xenopus tropicalis)
RHEA:68328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + H2O = (R)-pantetheine + phosphate
RHEA:34909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdate(out) => molybdate(in)
GO:0004635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyladenosine monophosphate cyclohydrolase activity
GO:0004635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosyl-AMP cyclohydrolase activity
GO:0004635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PRAMP-cyclohydrolase activity
GO:0004635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity
REACT:R-MMU-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Mus musculus)
REACT:R-BTA-5368596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Bos taurus)
RHEA:47336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Bos taurus)
REACT:R-BTA-2022052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Bos taurus)
REACT:R-MMU-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Mus musculus)
REACT:R-XTR-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Xenopus tropicalis)
REACT:R-XTR-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Xenopus tropicalis)
RHEA:62362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMN-N(5)-peroxide + uracil
REACT:R-GGA-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Gallus gallus)
REACT:R-MMU-8862184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP48 cleaves polyubiquitin (Mus musculus)
REACT:R-HSA-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Homo sapiens)
REACT:R-DDI-71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Dictyostelium discoideum)
REACT:R-SSC-9013023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GEFs activate RHOB (Sus scrofa)
RHEA:25224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-cysteate <=> CO2 + taurine
REACT:R-DME-1678708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(2) (Drosophila melanogaster)
RHEA:42658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthine-[translation elongation factor 2] + H(+) + methanol => diphthine methyl ester-[translation elongation factor 2] + H2O
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen synthase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPG-starch glucosyltransferase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPG starch synthetase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	starch synthase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine diphosphoglucose-starch glucosyltransferase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-glucose starch synthase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-glucose transglucosylase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine diphosphate glucose-starch glucosyltransferase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	starch synthetase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-glucose--starch glucosyltransferase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	starch (bacterial glycogen) synthase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPglucose-starch glucosyltransferase activity
GO:0009011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity
RHEA:16175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-norcoclaurine + H2O => (4-hydroxyphenyl)acetaldehyde + dopamine
REACT:R-BTA-9627106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) forms dimer (Bos taurus)
RHEA:16523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DRE-9758604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of IKBKG by TRAF6 (Danio rerio)
RHEA:43324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
REACT:R-CFA-5634729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Canis familiaris)
REACT:R-SSC-6785607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCM binds FAAP24 (Sus scrofa)
REACT:R-CEL-3965447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein subunits dissociate from WNT:FZD complex (Caenorhabditis elegans)
REACT:R-CFA-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Canis familiaris)
REACT:R-RNO-205238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 interacts with p-KIT (Rattus norvegicus)
GO:0047789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	creatinine amidohydrolase activity
GO:0047789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatininase activity
GO:0047789	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	creatinine hydrolase
REACT:R-MMU-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)
RHEA:14978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2,5-dihydro-5-oxofuran-2-acetate => 3-carboxy-cis,cis-muconate
REACT:R-HSA-9005994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC3 gene transcription is stimulated by MECP2 (Homo sapiens)
REACT:R-HSA-9694521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)
RHEA:39928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:13471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylbarbiturate + AH2 + H(+) => A + H2O + thymine
REACT:R-CFA-373724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds NCK (Canis familiaris)
REACT:R-HSA-912429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of meiotic holliday junction (Homo sapiens)
REACT:R-RNO-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Rattus norvegicus)
REACT:R-HSA-5694109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer hydrolyses TAG to DAG and FA (Homo sapiens)
GO:0015519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose:hydrogen symporter activity
GO:0015519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose:proton symporter activity
REACT:R-DRE-2534346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAM1 Binds Hyaluronic Acid (Danio rerio)
RHEA:57651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trichosetin <=> equisetin + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-5668404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFA binds TNFR2 (Rattus norvegicus)
RHEA:69289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate => sulfate + sulforaphane
REACT:R-CEL-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Caenorhabditis elegans)
REACT:R-DRE-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Danio rerio)
REACT:R-DRE-166542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-NGF dimer binds to TrkA receptor (Danio rerio)
REACT:R-RNO-211873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)
REACT:R-XTR-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Xenopus tropicalis)
REACT:R-DRE-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Danio rerio)
REACT:R-XTR-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Xenopus tropicalis)
RHEA:69431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite + 3 glutathione + H(+) <=> arsenic triglutathione + 3 H2O
REACT:R-HSA-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Homo sapiens)
GO:0033741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-sulfate reductase (glutathione) activity
GO:0033741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity
GO:0033741	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plant-type 5'-adenylylsulfate reductase activity
GO:0033741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity
GO:0033741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-adenylylsulfate reductase activity
REACT:R-DRE-1504213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Danio rerio)
RHEA:49416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-D-ribose-1-phosphate 5-kinase (ADP)"
RHEA:49416	skos:prefLabel	"alpha-D-ribose-1-phosphate 5-kinase (ADP)"
RHEA:49416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + AMP + H(+)
REACT:R-CFA-5607744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 binds BCL10 (Canis familiaris)
REACT:R-DME-1483159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho is dephosphorylated to Cho by PHOSPHO1 (Drosophila melanogaster)
RHEA:50717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfone + FMNH2 + O2 => FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate
RHEA:66722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate => ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in)
GO:0102773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide kinase activity
REACT:R-CFA-9020251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Canis familiaris)
REACT:R-DME-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Drosophila melanogaster)
RHEA:38939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioscin + 2 H2O = diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose
RHEA:38939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dioscin glycosidase (3-O-beta-D-Glc-diosgenin-forming)"
RHEA:38939	skos:prefLabel	"dioscin glycosidase (3-O-beta-D-Glc-diosgenin-forming)"
RHEA:38939	skos:altLabel	"dioscin-alpha-L-rhamnosidase"
RHEA:10060	skos:prefLabel	"D-tryptophan N-acetyltransferase"
RHEA:10060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-tryptophan = CoA + H(+) + N-acetyl-D-tryptophan
RHEA:10060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-tryptophan N-acetyltransferase"
REACT:R-DDI-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Dictyostelium discoideum)
REACT:R-RNO-8862771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G2A binds bacterial phospholipids (Rattus norvegicus)
RHEA:67118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine
REACT:R-XTR-9700171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates PLCG1 (Xenopus tropicalis)
REACT:R-MMU-349455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MDM4 by ATM (Mus musculus)
REACT:R-SSC-5638332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)
REACT:R-SCE-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Saccharomyces cerevisiae)
REACT:R-XTR-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Xenopus tropicalis)
REACT:R-CFA-5696358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREM,CD300 binds lipids (Canis familiaris)
REACT:R-BTA-2022056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPG and CSPG translocate to the lysosome for degradation (Bos taurus)
RHEA:29181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+) + 2 superoxide => a menaquinol + 2 O2
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartyl-tRNA(Asn) amidotransferase activity
GO:0050566	skos:prefLabel	"asparaginyl-tRNA synthase (glutamine-hydrolyzing)"
GO:0050566	skos:altLabel	"Asp-tRNA(Asn) amidotransferase"
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Asp-tRNAAsn amidotransferase activity
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Asp-AdT activity
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparaginyl-tRNA synthase (glutamine-hydrolysing)
GO:0050566	skos:altLabel	"Asp-AdT"
GO:0050566	skos:altLabel	"GatCAB"
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Asp-tRNA(Asn) amidotransferase activity
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)
GO:0050566	skos:altLabel	"aspartyl-tRNA(Asn) amidotransferase"
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"asparaginyl-tRNA synthase (glutamine-hydrolyzing)"
GO:0050566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartyl-tRNAAsn amidotransferase activity
RHEA:67107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + fumigatonoid C + O2 <=> CO2 + H2O + novofumigatonin + succinate
REACT:R-DDI-350869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Dictyostelium discoideum)
REACT:R-HSA-3000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BORA binds SCF-beta-TrCp1/2 (Homo sapiens)
REACT:R-HSA-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)
REACT:R-SCE-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Saccharomyces cerevisiae)
RHEA:55525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-dopa + O2 => 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)
GO:0102480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-fluorocytosine deaminase activity
RHEA:12165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a phenol => adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)
REACT:R-GGA-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Gallus gallus)
REACT:R-MMU-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Mus musculus)
REACT:R-RNO-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)
REACT:R-BTA-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Bos taurus)
REACT:R-SSC-8964614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Sus scrofa)
REACT:R-MMU-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Mus musculus)
RHEA:56988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8951549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbocymycobactin binds Fe3+ from LTF:2xFe3+:2xCO3(2-) (Homo sapiens)
RHEA:15806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-7,8-diammoniononanoate + ATP + CO2 => (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate
REACT:R-RNO-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Rattus norvegicus)
RHEA:45198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+) => 5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein]
RHEA:56131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dimethylallyl diphosphate + H2O + nonaflavuxanthin <=> AH2 + diphosphate + flavuxanthin
REACT:R-RNO-6814670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Rattus norvegicus)
RHEA:52709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H2O => D-ribose 5-phosphate + guanine
RHEA:12879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + methylglyoxal => acetylacetone + O2
REACT:R-RNO-1475026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (cytosol) (Rattus norvegicus)
REACT:R-HSA-9636261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOS2 gene produces NOS2 protein (Homo sapiens)
RHEA:59720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaono-1,5-lactone + H2O = D-maltohexaonate + H(+)
GO:0018698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vinyl chloride reductive dehalogenase activity
RHEA:63972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydropyriculol = AH2 + pyriculol
RHEA:42334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate => ATP + L-glutamate + oxidized coenzyme F420-2
REACT:R-SSC-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Sus scrofa)
GO:1990808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-bar domain binding
RHEA:68437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 => (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartylglycosylamine amidohydrolase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartylglucosaminidase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosylamidase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartylglucosylaminidase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-aspartyl-beta-glucosaminidase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-aspartylglucosylamine amidohydrolase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartylglucosylaminase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartylglucosylamine deaspartylase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity
GO:0003948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycosylasparaginase activity
RHEA:20463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine
RHEA:40372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)
REACT:R-BTA-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
REACT:R-DRE-9696323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNRs bind CNR agonists (Danio rerio)
REACT:R-HSA-2161195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Homo sapiens)
REACT:R-XTR-8987156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Xenopus tropicalis)
RHEA:60757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone => cinerin I + CoA
REACT:R-CFA-352191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A8-mediated uptake of neutral amino acids (Canis familiaris)
RHEA:24565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo acid + succinyl-CoA => a 3-oxoacyl-CoA + succinate
GO:0050583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen dehydrogenase (NADP+) activity
GO:0050583	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:NADP+ oxidoreductase activity
GO:0050583	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-linked hydrogenase activity
GO:0050583	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-reducing hydrogenase activity
RHEA:40825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-SSC-9758604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
REACT:R-MMU-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Mus musculus)
REACT:R-MMU-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Mus musculus)
REACT:R-DDI-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Dictyostelium discoideum)
REACT:R-DRE-1022133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Danio rerio)
REACT:R-HSA-9036068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GUSB does not hydrolyse GlcA-β1,3-GlcNAc (Homo sapiens)
REACT:R-HSA-2152276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of transmembrane collagens (Homo sapiens)
REACT:R-CEL-5638157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)
RHEA:17915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + nitrate => H2O + NAD(+) + nitrite
REACT:R-DRE-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Danio rerio)
REACT:R-RNO-1169397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ISG15 by UBA7 E1 ligase (Rattus norvegicus)
RHEA:59844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl alcohol + H(+) + NADPH = (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)
REACT:R-XTR-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Xenopus tropicalis)
RHEA:63987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine + ATP <=> 5-hydroxyuridine 5'-phosphate + ADP + H(+)
REACT:R-GGA-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Gallus gallus)
RHEA:10270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxopropanoate + pyruvate => 2-dehydro-3-deoxy-D-glucarate
GO:0102617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oryzalexin C synthase (oryzalexin B dependent) activity
RHEA:34248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxymethyl-sphinganine + NADP(+) => 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH
REACT:R-BTA-9701003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 heterodimer (Bos taurus)
REACT:R-SCE-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Saccharomyces cerevisiae)
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in non-canonical Wnt signaling pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in PCP pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in Wnt-PCP signaling pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wnt/PCP co-receptor activity
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in PCP pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Wnt co-receptor, non-canonical pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor activity involved in Wnt-JNK signaling pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Wnt co-receptor activity, non-canonical signaling
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in Wnt-PCP signaling pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt receptor signaling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor activity involved in Wnt-PCP signaling pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in non-canonical Wnt signaling pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in Wnt-JNK signaling pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt-activated signaling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in Wnt-JNK signaling pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt receptor signalling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in PCP pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor activity involved in non-canonical Wnt signaling pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway
GO:1904929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway
RHEA:53713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-heme b => beta-hematin
RHEA:39066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + scyllo-inositol <=> H(+) + NADPH + scyllo-inosose
GO:0005506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron binding
GO:0005506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron ion binding
REACT:R-DRE-380508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NuMA to the centrosomes (Danio rerio)
REACT:R-RNO-158784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Rattus norvegicus)
RHEA:39523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA = (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoisocaproic dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BCKDH activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain (-2-oxoacid) dehydrogenase (BCD) activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched chain keto acid dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-ketoacid dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain 2-keto acid dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain alpha-keto acid dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain keto acid dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoisovalerate (lipoate) dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoisocaproate dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain alpha-oxo acid dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-oxoisocaproate dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-keto-alpha-methylvalerate dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain ketoacid dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoisovalerate dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, 2-oxoisovalerate (lipoate) activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, branched chain alpha-keto acid activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BCOAD activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain 2-oxo acid dehydrogenase activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity
GO:0003863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoisocaproate dehydrogenase activity
GO:0051731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-hydroxyl polynucleotide kinase activity
GO:0051731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-dephosphopolynucleotide kinase activity
GO:0051731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polynucleotide 5'-hydroxy-kinase activity
GO:0051731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polynucleotide 5'-hydroxyl-kinase activity
GO:0051731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polynucleotide 5'-hydroxyl kinase (phosphorylating) activity
GO:0051731	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polynucleotide kinase activity
GO:0051731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PNK
RHEA:20304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginine + tRNA(Arg) <=> AMP + diphosphate + L-arginyl-tRNA(Arg)
REACT:R-MMU-1912369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH precursor cleaved to form mature NOTCH (Mus musculus)
REACT:R-RNO-68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Rattus norvegicus)
REACT:R-DME-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Drosophila melanogaster)
RHEA:38002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine <=> H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine
REACT:R-DDI-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Dictyostelium discoideum)
REACT:R-CEL-418172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB2 (Caenorhabditis elegans)
REACT:R-BTA-5693539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of DNA and formation of Holliday structures following repair synthesis (Bos taurus)
GO:0046934	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase activity, class I
GO:0046934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity
GO:0046934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046934	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase, class I, catalyst activity
GO:0046934	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type I phosphoinositide 3-kinase activity
GO:0046934	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase activity, class II
REACT:R-BTA-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Bos taurus)
RHEA:39152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-CoA + NADP(+)
EC:3.6.5.2	skos:prefLabel	"small monomeric GTPase"
EC:3.6.5.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"small monomeric GTPase"
REACT:R-XTR-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Xenopus tropicalis)
RHEA:27774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:51375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-glycine
GO:0048030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	disaccharide binding
REACT:R-RNO-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)
RHEA:69520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-galactosamino-1,5-lactone = H(+) + N-acetyl-D-galactosaminate
RHEA:57412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-tyrosinal + NADP(+) = ATP + H(+) + L-tyrosine + NADPH
RHEA:57412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-tyrosine reductase"
RHEA:57412	skos:prefLabel	"L-tyrosine reductase"
RHEA:57904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate
REACT:R-MMU-9606151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
REACT:R-RNO-5683385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of BRCA1-A complex at DNA DSBs (Rattus norvegicus)
RHEA:49677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 => H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)
REACT:R-DRE-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Danio rerio)
RHEA:68432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutein + O2 = (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal
REACT:R-CEL-8874685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds MET (Caenorhabditis elegans)
RHEA:15673	skos:prefLabel	"acetoacetyl-CoA hydrolase"
RHEA:15673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetoacetyl-CoA hydrolase"
RHEA:15673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)
REACT:R-DME-2730841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV (Drosophila melanogaster)
REACT:R-RNO-77319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Rattus norvegicus)
RHEA:38489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + glycerol + H(+) => 1-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-BTA-354149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
REACT:R-MMU-4086083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of ING2 with SUMO1 (Mus musculus)
GO:0008092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal protein binding
REACT:R-XTR-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Xenopus tropicalis)
RHEA:57661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:11555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + acetate + H(+)
RHEA:18345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cis-3-alkyl-4-alkyloxetan-2-one = a cis-alkene + CO2
RHEA:18345	skos:prefLabel	"cis-3-alkyl-4-alkyloxetan-2-one decarboxylase"
RHEA:18345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-3-alkyl-4-alkyloxetan-2-one decarboxylase"
RHEA:38072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA
REACT:R-HSA-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Homo sapiens)
RHEA:36811	skos:altLabel	"GDP-alpha-D-perosamine N-acetyltransferase"
RHEA:36811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + GDP-alpha-D-perosamine = CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)
RHEA:36811	skos:prefLabel	"GDP-perosamine N-acetyltransferase"
RHEA:36811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-perosamine N-acetyltransferase"
EC:2.4.2.28	skos:prefLabel	"S-methyl-5'-thioadenosine phosphorylase"
EC:2.4.2.28	skos:altLabel	"5'-deoxy-5'-methylthioadenosine phosphorylase"
EC:2.4.2.28	skos:altLabel	"methylthioadenosine phosphorylase"
EC:2.4.2.28	skos:altLabel	"MeSAdo/Ado phosphorylase"
EC:2.4.2.28	skos:altLabel	"5'-methylthioadenosine phosphorylase"
EC:2.4.2.28	skos:altLabel	"MTA phosphorylase"
EC:2.4.2.28	skos:altLabel	"MTAPase"
EC:2.4.2.28	skos:altLabel	"methylthioadenosine nucleoside phosphorylase"
EC:2.4.2.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-methyl-5'-thioadenosine phosphorylase"
EC:2.4.2.28	skos:altLabel	"MeSAdo phosphorylase"
RHEA:32367	skos:altLabel	"L-galactono-gamma-lactone dehydrogenase"
RHEA:32367	skos:altLabel	"galactonolactone dehydrogenase"
RHEA:32367	skos:altLabel	"GLDHase"
RHEA:32367	skos:prefLabel	"L-galactonolactone dehydrogenase"
RHEA:32367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-galactonolactone dehydrogenase"
RHEA:32367	skos:altLabel	"GLDase"
RHEA:32367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone = 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate
REACT:R-HSA-9674408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regorafenib-resistant PDGFR mutants don't bind regorafenib (Homo sapiens)
GO:0001784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphotyrosine residue binding
GO:0001784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotyrosine binding
RHEA:56066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose
REACT:R-PFA-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Plasmodium falciparum)
REACT:R-SSC-8983059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Sus scrofa)
RHEA:18351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-aspartyl-tRNA(Asx) => ATP + L-aspartate + tRNA(Asx)
RHEA:70321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3,4-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O
REACT:R-SSC-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Sus scrofa)
REACT:R-XTR-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Xenopus tropicalis)
REACT:R-GGA-419426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cannabinoid receptors can bind cannabinoids (Gallus gallus)
GO:0003874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTPS activity
GO:0003874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)
GO:0003874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-pyruvoyltetrahydropterin synthase activity
GO:0003874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-pyruvoyl tetrahydrobiopterin synthase activity
GO:0003874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity
REACT:R-HSA-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Homo sapiens)
RHEA:47311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Dictyostelium discoideum)
REACT:R-HSA-5655339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 mutants bind FRS2 (Homo sapiens)
RHEA:55374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + jasmonate + methanol => H2O + methyl (-)-jasmonate
REACT:R-BTA-9793680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)
REACT:R-MMU-9640168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)
RHEA:66513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-6814096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds SCOC (Sus scrofa)
REACT:R-SCE-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Saccharomyces cerevisiae)
REACT:R-DRE-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Danio rerio)
REACT:R-CEL-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Caenorhabditis elegans)
RHEA:69795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartyl-tRNA(Asp) + H2O = D-aspartate + H(+) + tRNA(Asp)
REACT:R-XTR-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Xenopus tropicalis)
REACT:R-BTA-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Bos taurus)
REACT:R-GGA-193703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta is activated (Gallus gallus)
GO:0032453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-methyl-lysine-4 demethylase activity
GO:0032453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity (H3K4-specific)
GO:0032453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K4 demethylase activity
GO:0032453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity (H3-K4 specific)
GO:0032453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K4 demethylase activity
RHEA:61717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-galactofuranose(out) + H2O => ADP + D-galactofuranose(in) + H(+) + phosphate
REACT:R-SPO-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Schizosaccharomyces pombe)
REACT:R-HSA-2976551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 stimulates GZMB transcription (Homo sapiens)
RHEA:70020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + typhasterol => 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5626228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The distal appendage proteins recruit TTBK2 (Canis familiaris)
REACT:R-DME-9708557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 binds BACH1:MAFK (Drosophila melanogaster)
GO:0016688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ascorbate:hydrogen-peroxide oxidoreductase activity
GO:0016688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate peroxidase activity
GO:0016688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ascorbic acid-specific peroxidase activity
GO:0016688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ascorbic acid peroxidase activity
GO:0016688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascorbate peroxidase activity
GO:0016688	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascorbic acid peroxidase activity
GO:0004025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol dehydrogenase activity, iron-dependent
REACT:R-DME-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Drosophila melanogaster)
RHEA:27359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodomethane + S-adenosyl-L-homocysteine => iodide + S-adenosyl-L-methionine
REACT:R-RNO-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Rattus norvegicus)
REACT:R-CEL-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)
REACT:R-SSC-9026405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Sus scrofa)
RHEA:55534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-phenylalanine + O2
RHEA:28967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)
GO:0043875	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	keto-acid formate acetyltransferase
GO:0043875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KFL
GO:0043875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CoA = formate + propanoyl-CoA
GO:0043875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TdcE
GO:0043875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ketobutyrate formate-lyase activity
GO:0042951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arbutin transmembrane transporter activity
REACT:R-BTA-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Bos taurus)
REACT:R-MMU-204981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3epsilon attentuates NADE-related apoptosis (Mus musculus)
REACT:R-SSC-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Sus scrofa)
REACT:R-MMU-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)
RHEA:43232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isatin hydrolase"
RHEA:43232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isatin = H(+) + isatinate
RHEA:43232	skos:prefLabel	"isatin hydrolase"
REACT:R-SSC-389491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two NPFF receptors can bind neuropeptide FF (Sus scrofa)
REACT:R-BTA-8852509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL-LK binds carbohydrates on target cell surface (Bos taurus)
REACT:R-RNO-375339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Rattus norvegicus)
REACT:R-GGA-183084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)
REACT:R-MMU-9756162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)
RHEA:50047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)
RHEA:40584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanedioyl-CoA => CoA + H(+) + hexanedioate
RHEA:14968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl phosphate + H2O <=> a carboxylate + H(+) + phosphate
RHEA:34704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (E)-2-epi-beta-caryophyllene + diphosphate
REACT:R-HSA-6787737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3R binds CSF3 dimer (Homo sapiens)
REACT:R-MMU-5635865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 dissociates from ub-PTCH1 (Mus musculus)
GO:0043892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Gre2
GO:0043892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactaldehyde:NADP+ oxidoreductase activity
GO:0043892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylglyoxal reductase (NADPH-dependent) activity
GO:0043892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactaldehyde dehydrogenase (NADP+)
REACT:R-DRE-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Danio rerio)
RHEA:19656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH
REACT:R-HSA-211968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2W1 oxidises INDOL (Homo sapiens)
RHEA:53166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-975593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Homo sapiens)
RHEA:47524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
RHEA:55298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinyl hexadecanoate + CoA => 13-cis-retinol + hexadecanoyl-CoA
RHEA:62203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + 2 Fe(III)-[cytochrome c] <=> acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-GGA-8950456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B dimerizes (Gallus gallus)
REACT:R-SSC-2872497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-2 transports cytosolic urate to extracellular region (Sus scrofa)
REACT:R-HSA-163672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ChREBP at Thr(666) by PKA (Homo sapiens)
REACT:R-DME-209289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase (Drosophila melanogaster)
REACT:R-SSC-933536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7 dimer interacts with coactivator CBP/p300 (Sus scrofa)
REACT:R-DME-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Drosophila melanogaster)
RHEA:51572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-450187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated within the TAK1 complex (Danio rerio)
GO:0015174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	basic amino acid permease activity
GO:0015174	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	basic amino acid transporter activity
GO:0015174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	basic amino acid transmembrane transporter activity
GO:0015174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cationic amino acid transmembrane transporter activity
REACT:R-GGA-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Gallus gallus)
RHEA:46142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:63320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid(in) + ATP + H2O = a glycerophospholipid(out) + ADP + H(+) + phosphate
RHEA:34294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose <=> 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP
GO:0046969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone H3K9 deacetylase activity
GO:0046969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
GO:0046969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent H3-K9 histone deacetylase activity
GO:0046969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone deacetylase activity (H3-K9 specific)
RHEA:19462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)
GO:0072549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity
REACT:R-SSC-388828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PD-1 binds B7DC and B7H1 (Sus scrofa)
REACT:R-SSC-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Sus scrofa)
RHEA:54740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0034906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-isopropylaniline 1,2-dixoxygenase activity
RHEA:12989	skos:altLabel	"mannosylphosphodolichol phosphodiesterase"
RHEA:12989	skos:prefLabel	"dolichylphosphate-mannose phosphodiesterase"
RHEA:12989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + H2O = a dolichyl phosphate + D-mannose + H(+)
RHEA:12989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichylphosphate-mannose phosphodiesterase"
REACT:R-HSA-9623281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1:PPARGC1A,FOXO4 binds PCK1 gene promoter (Homo sapiens)
REACT:R-BTA-5607753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD9 oligomerizes (Bos taurus)
REACT:R-MMU-174447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation on the C-strand of the telomere (Mus musculus)
RHEA:38296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2
RHEA:40985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+) => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O
REACT:R-CEL-390598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Caenorhabditis elegans)
REACT:R-DRE-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Danio rerio)
REACT:R-GGA-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Gallus gallus)
RHEA:44425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + heptadecasphing-4-enine => CoA + H(+) + N-acyl-heptadecasphing-4-enine
REACT:R-SSC-447130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-23 binds interleukin-23 receptor (Sus scrofa)
RHEA:22578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-homoserine + H(+) => an N-acyl-L-homoserine lactone + H2O
GO:0050019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NAD(+) = H(+) + L-xylulose + NADH
GO:0050019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol 4-dehydrogenase activity
GO:0050019	skos:prefLabel	"L-arabinitol 4-dehydrogenase"
GO:0050019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arabinitol 4-dehydrogenase"
REACT:R-RNO-4724279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Rattus norvegicus)
REACT:R-CFA-6793666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the nucleus (Canis familiaris)
REACT:R-RNO-75886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Rattus norvegicus)
GO:0019162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine--oxaloacetate aminotransferase activity
GO:0019162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine:oxaloacetate aminotransferase activity
GO:0019162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine-oxaloacetate aminotransferase activity
GO:0019162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine-oxaloacetate transaminase activity
RHEA:24825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:41389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate
REACT:R-MMU-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Mus musculus)
REACT:R-HSA-9625101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1 and SIN3A:HDAC complex bind GCK gene promoter (Homo sapiens)
REACT:R-XTR-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Xenopus tropicalis)
REACT:R-MMU-8985201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL (Mus musculus)
GO:0102918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline 7-O-methyltransferase activity
GO:0102057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonoyl-valine synthetase activity
RHEA:45353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxyoctadecanoate + H2O => 9,10-dihydroxyoctadecanoate
RHEA:42992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nephthenol synthase"
RHEA:42992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate
RHEA:42992	skos:prefLabel	"nephthenol synthase"
RHEA:63083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + ilicicolinate B <=> A + AMP + diphosphate + ilicicolin B
REACT:R-MMU-390252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)
REACT:R-CFA-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Canis familiaris)
REACT:R-HSA-9665389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)
RHEA:54769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide
RHEA:13122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + shikimate => 3-phosphoshikimate + ADP + H(+)
REACT:R-SCE-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Saccharomyces cerevisiae)
REACT:R-HSA-5683735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 is recruited to DNA DSBs (Homo sapiens)
RHEA:55152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] = (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]
RHEA:55152	skos:prefLabel	"L-prolyl-[peptidyl-carrier protein] dehydrogenase"
RHEA:55152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-prolyl-[peptidyl-carrier protein] dehydrogenase"
RHEA:36461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-proline => glycyl-L-proline + H2O
RHEA:70447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate
RHEA:54647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O
RHEA:55508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:55508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cucurbitadienol 11-hydroxylase"
RHEA:55508	skos:altLabel	"CYP87D18"
RHEA:55508	skos:prefLabel	"cucurbitadienol 11-hydroxylase"
RHEA:38591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine = chloroorienticin B + dTDP + H(+)
RHEA:38591	skos:prefLabel	"dTDP-epi-vancosaminyltransferase"
RHEA:38591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-epi-vancosaminyltransferase"
RHEA:72541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 H(+) + NADPH => 3,4-dihydroxybenzaldehyde + H2O + NADP(+)
REACT:R-HSA-158340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Homo sapiens)
RHEA:60476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + GTP = 3',3',3'-cAAG + 3 diphosphate
REACT:R-SSC-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Sus scrofa)
RHEA:12919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + strictosidine aglycone => 3alpha(S)-strictosidine + H2O
REACT:R-HSA-1236955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Movement of clathrin coated vesicles into early endosome (Homo sapiens)
RHEA:71351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone 3alpha-sulfate(out) + 2 Na(+)(out) = androsterone 3alpha-sulfate(in) + 2 Na(+)(in)
REACT:R-RNO-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Rattus norvegicus)
REACT:R-XTR-5693566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 associates with H4K20Me2 at DNA DSBs (Xenopus tropicalis)
RHEA:17847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+)
REACT:R-BTA-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Bos taurus)
RHEA:47369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)
REACT:R-MMU-5610767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Mus musculus)
REACT:R-HSA-170978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-FRS2:CRKL binds C3G (Homo sapiens)
GO:0048257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-flap endonuclease activity
GO:0048257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' flap endonuclease activity
REACT:R-HSA-9698924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B Nucleocapsid Assembly (Homo sapiens)
REACT:R-HSA-9663511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds GSTA1, FABP1 (Homo sapiens)
REACT:R-HSA-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Homo sapiens)
REACT:R-HSA-5661114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Homo sapiens)
REACT:R-MMU-449976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)
REACT:R-XTR-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Xenopus tropicalis)
REACT:R-SSC-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Sus scrofa)
REACT:R-HSA-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Homo sapiens)
REACT:R-HSA-8937097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
REACT:R-GGA-9021357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCI phosphorylates ELF3 (Gallus gallus)
REACT:R-CEL-2065539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:Importin beta-1 dissociates (Caenorhabditis elegans)
REACT:R-HSA-193743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
RHEA:58672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate = aldehydo-D-glucuronate
REACT:R-CFA-8866308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL translocates from RER membrane to SER lumen (Canis familiaris)
REACT:R-DME-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Drosophila melanogaster)
RHEA:55602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose
RHEA:32833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an R-cob(III)alamin(out) => an R-cob(III)alamin(in)
GO:0001632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 receptor activity
GO:0001632	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	BLT receptor
REACT:R-GGA-2022381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)
RHEA:60978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H(+) + NADH => (E)-4-hydroxynon-2-en-1-ol + NAD(+)
RHEA:13129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-coumarate + UDP-alpha-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP
RHEA:13129	skos:prefLabel	"cis-p-coumarate glucosyltransferase"
RHEA:13129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-p-coumarate glucosyltransferase"
RHEA:51410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O
REACT:R-DME-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Drosophila melanogaster)
REACT:R-CFA-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Canis familiaris)
REACT:R-RNO-77345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Rattus norvegicus)
RHEA:47261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + CO2 => H(+) + phenylglyoxylate
REACT:R-RNO-389762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PD-1 (Rattus norvegicus)
RHEA:38048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-RNO-349444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of COP1 at Ser-387  by ATM (Rattus norvegicus)
REACT:R-XTR-8942575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Xenopus tropicalis)
RHEA:69155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermine monoaldehyde <=> acrolein + spermidine
REACT:R-HSA-445753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Homo sapiens)
REACT:R-MMU-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Mus musculus)
REACT:R-SSC-5672329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CLIP1 and microtubules (Sus scrofa)
GO:0002061	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1,3-diazine binding
GO:0002061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine base binding
GO:0002061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine binding
GO:0002061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine nucleobase binding
RHEA:65089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] => asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:17873	skos:prefLabel	"ABC-type vitamin B12 transporter"
RHEA:17873	skos:altLabel	"vitamin B12 ABC transporter"
RHEA:17873	skos:altLabel	"vitamin B12-transporting ATPase"
RHEA:17873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an R-cob(III)alamin(out) + ATP + H2O = ADP + an R-cob(III)alamin(in) + H(+) + phosphate
RHEA:17873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type vitamin B12 transporter"
RHEA:48908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP
RHEA:11191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-cyano-L-alanine + 2 H2O <=> L-aspartate + NH4(+)
RHEA:15562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + sterigmatocystin => 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-110364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Rattus norvegicus)
REACT:R-DDI-419490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATP to P2X receptors (Dictyostelium discoideum)
RHEA:16038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + thymidine => 2-deoxy-alpha-D-ribose 1-phosphate + thymine
RHEA:39752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Saccharomyces cerevisiae)
RHEA:12339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxymethoxysuccinate <=> fumarate + glycolate
REACT:R-CFA-174121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Securin with Cdc20:APC/C complex (Canis familiaris)
RHEA:67452	skos:altLabel	"glucuronoyl-lignin ester hydrolase"
RHEA:67452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)
RHEA:67452	skos:altLabel	"4-O-methyl-glucuronoyl methylesterase"
RHEA:67452	skos:prefLabel	"(4-O-methyl)-D-glucuronate--lignin esterase"
RHEA:67452	skos:altLabel	"glucuronoyl esterase"
RHEA:67452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(4-O-methyl)-D-glucuronate--lignin esterase"
REACT:R-HSA-5692781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Homo sapiens)
REACT:R-MMU-77323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Mus musculus)
RHEA:58777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pyridine 3-methanol => H(+) + NADPH + pyridine-3-carbaldehyde
REACT:R-RNO-189384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLVRA:Zn2+, BLVRB reduce BV to BIL (Rattus norvegicus)
RHEA:40023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate + H2O = diphosphate + syn-copalol
RHEA:19459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + H2O + 2 NADP(+) + nitrite => 2-nitrophenol + 2 H(+) + 2 NADPH + O2
REACT:R-MMU-2395801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LAT by p-SYK (Mus musculus)
REACT:R-SSC-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Sus scrofa)
RHEA:69273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate => allyl isothiocyanate + sulfate
RHEA:54984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol = a ubiquinone + 2 e(-) + 2 H(+)
REACT:R-BTA-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Bos taurus)
RHEA:65241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + H2O => (11Z)-octadecenoate + CoA + H(+)
REACT:R-RNO-6785732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases bind monoubiquitinated ID2 complex (Rattus norvegicus)
REACT:R-DRE-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Danio rerio)
REACT:R-BTA-375302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules (Bos taurus)
REACT:R-DRE-8852167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:Catecholamine binds ARRB1, ARRB2 (Danio rerio)
RHEA:26260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroabietadienol + H(+) + NADPH + O2 <=> dehydroabietadienal + 2 H2O + NADP(+)
RHEA:23685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0004935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenergic receptor activity
GO:0004935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenoceptor activity
REACT:R-DDI-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Dictyostelium discoideum)
RHEA:35844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin
REACT:R-XTR-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Xenopus tropicalis)
RHEA:45251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) <=> butanoate(in)
RHEA:59695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotriono-1,5-lactone + H2O <=> D-cellotrionate + H(+)
REACT:R-SSC-1592436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP9 by MMPs (Sus scrofa)
GO:0001968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibronectin binding
REACT:R-BTA-5223313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Bos taurus)
REACT:R-BTA-388855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin-releasing hormone receptor binds PRH (Bos taurus)
REACT:R-CFA-392835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 sequesters Raf1 to inhibit ERK cascade (Canis familiaris)
REACT:R-DDI-203613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylation of eNOS (Dictyostelium discoideum)
REACT:R-HSA-9640175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)
REACT:R-SSC-1433454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GAB2 by SFKs (Sus scrofa)
REACT:R-XTR-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Xenopus tropicalis)
GO:0005375	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	copper uptake transmembrane transporter activity
GO:0005375	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plasma membrane copper transporter
GO:0005375	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intracellular copper ion transporter
GO:0005375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copper ion transmembrane transporter activity
REACT:R-DME-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
RHEA:31978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxusin <=> 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-AMP + CoA <=> (E)-feruloyl-CoA + AMP + H(+)
RHEA:20555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA
RHEA:62311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide B + FADH2
RHEA:72817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)
RHEA:70075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine
REACT:R-XTR-448703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family precursors are cleaved by caspase-1 (Xenopus tropicalis)
REACT:R-CFA-5669097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA trimer binds TNFRSF1A,1B,14 (Canis familiaris)
REACT:R-DME-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Drosophila melanogaster)
REACT:R-SCE-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Saccharomyces cerevisiae)
RHEA:18322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-leucine => 4-methyl-2-oxopentanoate + L-glutamate
REACT:R-CEL-6797653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMGDH:FAD oxidatively demethylates DMGLY to SARC (Caenorhabditis elegans)
RHEA:22758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + H2O2 => a long-chain primary fatty alcohol + O2
RHEA:65419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP(in) + NAD(+)(out) <=> dGMP(out) + NAD(+)(in)
REACT:R-BTA-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Bos taurus)
RHEA:61082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-echitovenine + CoA => (+)-minovincinine + acetyl-CoA
REACT:R-HSA-3827958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by MMP9, KLK7 (Homo sapiens)
RHEA:27813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + 2 diphosphate
REACT:R-SSC-4093327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHA binds TIAM1 (Sus scrofa)
RHEA:18080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[dinitrogen reductase] + NAD(+) <=> H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide
RHEA:25962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzil + H(+) + NADPH => benzoin + NADP(+)
RHEA:53045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:58252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] = ADP-D-ribose + L-asparaginyl-[protein]
REACT:R-SSC-2424482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p85 regulatory unit of PI3K binds p-6Y-SYK (Sus scrofa)
RHEA:17643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + CO2 => H(+) + L-arginine
RHEA:53915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]
REACT:R-HSA-5339713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)
REACT:R-BTA-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Bos taurus)
RHEA:36782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + GDP-alpha-D-perosamine <=> GDP-4-dehydro-alpha-D-rhamnose + L-glutamate
GO:0004533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exoribonuclease H activity
GO:0004533	skos:prefLabel	"exoribonuclease H"
GO:0004533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exoribonuclease H"
GO:0004533	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retroviral reverse transcriptase RNaseH
REACT:R-CFA-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Canis familiaris)
RHEA:35269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol(out) => ethanol(in)
RHEA:34828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 => H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)
RHEA:30154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + NADP(+) <=> FAD + 2 H(+) + NADPH
REACT:R-CFA-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Canis familiaris)
REACT:R-DME-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Drosophila melanogaster)
REACT:R-HSA-2454113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 transports 11cRAL to rod photoreceptor outer segment (Homo sapiens)
REACT:R-MMU-141431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
RHEA:66619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg(2+)(in) + 2 Na(+)(out) <=> Mg(2+)(out) + 2 Na(+)(in)
REACT:R-BTA-3229102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPKAPK3 phosphorylates BMI1 (Bos taurus)
REACT:R-BTA-1483063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG and CDP-DAG are converted to CL by CRLS1 (Bos taurus)
REACT:R-CEL-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Caenorhabditis elegans)
RHEA:63483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH
REACT:R-HSA-158419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)
RHEA:64900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UTP = H(+) + phosphate + UDP
REACT:R-DME-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)
RHEA:48770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-erythrulose 4-phosphate + H(+) => ATP + D-erythrulose
RHEA:53183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose <=> D-erythrulose
RHEA:58931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-7,2',4'-trihydroxyisoflavanol <=> (6aR,11aR)-3,9-dihydroxypterocarpan + H2O
REACT:R-SPO-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)
RHEA:12849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-[myosin light chain] = L-seryl-[myosin light chain] + phosphate
REACT:R-GGA-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Gallus gallus)
REACT:R-GGA-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Gallus gallus)
RHEA:28896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine(in) + L-lysine(out) => cadaverine(out) + L-lysine(in)
REACT:R-DRE-9686521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2:CCNA phosphorylates TERF2 (Danio rerio)
RHEA:51046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NH4(+) + protodeoxyviolaceinate => indole-3-pyruvate imine dimer
REACT:R-SSC-158784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Sus scrofa)
GO:0042658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	major histocompatibility complex class II protein binding, via antigen binding groove
GO:0042658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II protein binding, via antigen binding groove
REACT:R-DDI-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)
RHEA:13851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose => D-arabinose
REACT:R-XTR-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Xenopus tropicalis)
RHEA:42916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine
REACT:R-DME-372505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylcholine synaptic vesicle docking and priming (Drosophila melanogaster)
RHEA:20528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + ethylamine + L-glutamate <=> ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate
REACT:R-DME-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
RHEA:16411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + vomilenine => 1,2-dihydrovomilenine + NADP(+)
REACT:R-HSA-8951977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylated RUNX3 binds to BRD2 (Homo sapiens)
RHEA:29835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactonate(in) + H(+)(in) = D-galactonate(out) + H(+)(out)
RHEA:18807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-dithiol + [protein]-disulfide => [DsbA protein]-disulfide + [protein]-dithiol
RHEA:47612	skos:altLabel	"UDP-glucose-diacylglycerol glucosyltransferase"
RHEA:47612	skos:altLabel	"1,2-diacylglycerol 3-glucosyltransferase"
RHEA:47612	skos:prefLabel	"1,2-diacylglycerol 3-alpha-glucosyltransferase"
RHEA:47612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,2-diacylglycerol 3-alpha-glucosyltransferase"
RHEA:47612	skos:altLabel	"uridine diphosphoglucose-diacylglycerol glucosyltransferase"
RHEA:47612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP
REACT:R-HSA-5218812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates PAK2 (Homo sapiens)
REACT:R-MMU-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Mus musculus)
REACT:R-CEL-112342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of MAP2K1 by CDK1 (Caenorhabditis elegans)
RHEA:16543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9-cis-violaxanthin + O2
REACT:R-HSA-8987223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10RB binds TYK2 (Homo sapiens)
GO:0035250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactosyltransferase activity
RHEA:42240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:31487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose = H(+) + soyasaponin III + UDP
RHEA:31487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"soyasapogenol B glucuronide galactosyltransferase"
RHEA:31487	skos:prefLabel	"soyasapogenol B glucuronide galactosyltransferase"
REACT:R-DME-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Drosophila melanogaster)
REACT:R-BTA-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Bos taurus)
GO:0047590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DKH kinase activity
GO:0047590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity
GO:0047590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-keto-2-deoxyglucono kinase (phosphorylating)
GO:0047590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-keto-2-deoxygluconokinase activity
GO:0047590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-2-deoxygluconokinase activity
REACT:R-BTA-351863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active caspase-8 to the mitochondrial membrane (Bos taurus)
REACT:R-DME-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Drosophila melanogaster)
REACT:R-DME-1678716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(1) (Drosophila melanogaster)
GO:0018620	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)
GO:0018620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phthalate 4,5-dioxygenase activity
GO:0018620	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phthalate dioxygenase activity
GO:0018620	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDO activity
RHEA:65224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol
REACT:R-SSC-2327733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 binds Collagen types I-V, VII (Sus scrofa)
RHEA:71929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + tauroursodeoxycholate(in) => 2 Na(+)(out) + tauroursodeoxycholate(out)
REACT:R-CFA-450984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Canis familiaris)
RHEA:42670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-rhamnono-1,4-lactone + NADPH => L-rhamnofuranose + NADP(+)
GO:0035594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside binding
REACT:R-HSA-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Homo sapiens)
REACT:R-HSA-443784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-heterodimerization of L1 and Contactin-1/F3/F11 (Homo sapiens)
REACT:R-MMU-5694077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Mus musculus)
RHEA:51749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A => 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate
REACT:R-RNO-5696482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTF1 binds LIFR:JAKs (Rattus norvegicus)
RHEA:56507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:72023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate(in) + urate(out) = nicotinate(out) + urate(in)
REACT:R-HSA-193679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-secretase cleaves the p75NTR extracellular domain (Homo sapiens)
RHEA:37759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DME-209536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkB is ubiquitinated and degraded (Drosophila melanogaster)
REACT:R-BTA-8943003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH polyubiquitinates monoubiquitinated PCNA (Bos taurus)
RHEA:40720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione => an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)
REACT:R-PFA-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)
EC:1.11.2.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"unspecific peroxygenase"
EC:1.11.2.1	skos:altLabel	"haloperoxidase-peroxygenase"
EC:1.11.2.1	skos:prefLabel	"unspecific peroxygenase"
RHEA:37587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + L-glutamate
REACT:R-CEL-3928627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB phosphorylates TIAM1 (Caenorhabditis elegans)
REACT:R-SSC-6805755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 dimethylates TP53 (Sus scrofa)
REACT:R-DRE-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Danio rerio)
RHEA:35266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
REACT:R-SSC-5656064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FLRT1,2,3 (Sus scrofa)
RHEA:57107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) <=> 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)
RHEA:18626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + NADP(+) => D-galactono-1,5-lactone + H(+) + NADPH
REACT:R-CFA-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Canis familiaris)
REACT:R-GGA-5607740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta phosphorylates CARD9 (Gallus gallus)
REACT:R-SSC-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Sus scrofa)
REACT:R-HSA-1220611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)
RHEA:55579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine <=> H(+) + psilocybin + S-adenosyl-L-homocysteine
RHEA:30882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + prop-2-ynal <=> 2 H(+) + NADH + propynoate
RHEA:72948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(out) + 2 Na(+)(out) => acetate(in) + 2 Na(+)(in)
RHEA:65372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer = CMP + globoside MSGG + H(+)
RHEA:13104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propanoate <=> H2O + trans-urocanate
RHEA:32650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin C + S-adenosyl-L-methionine <=> erythromycin A + H(+) + S-adenosyl-L-homocysteine
RHEA:41170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)
RHEA:72822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)
REACT:R-XTR-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Xenopus tropicalis)
GO:0047815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinonolactonase activity
GO:0047815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinono-1,4-lactone lactonohydrolase activity
RHEA:42655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine <=> diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine
RHEA:10574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA => vinylacetyl-CoA
REACT:R-DDI-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Dictyostelium discoideum)
RHEA:42976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan = 2-aminoprop-2-enoate + indole
REACT:R-XTR-9614273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGRG heterodimer translocates to plasma membrane (Xenopus tropicalis)
RHEA:34281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)
REACT:R-HSA-9010096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713) (Homo sapiens)
GO:0106267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O
GO:0106267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5 dichloro-THPH synthase activity
GO:0033794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine = [thioredoxin]-dithiol + H(+) + phosphate + sarcosine
GO:0033794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity
GO:0033794	skos:prefLabel	"sarcosine reductase"
GO:0033794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sarcosine reductase"
GO:0033794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sarcosine reductase activity
REACT:R-XTR-5675470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC2/3 (cIAP1/2) is autoubiquitinated (Xenopus tropicalis)
REACT:R-MMU-1855180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Mus musculus)
REACT:R-DME-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Drosophila melanogaster)
GO:0018803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)
GO:0018803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2'-carboxybenzalpyruvate hydratase-aldolase activity
GO:0018803	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity
GO:0018803	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity
GO:0018803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-carboxybenzalpyruvate aldolase activity
GO:0018803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity
REACT:R-XTR-2424476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV2/3 (Xenopus tropicalis)
RHEA:39479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)
RHEA:28337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + H2O <=> dAMP + diphosphate + H(+)
RHEA:29966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + inosine(in) <=> H(+)(out) + inosine(out)
REACT:R-CFA-428909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-protein  G13 (Canis familiaris)
REACT:R-HSA-9707594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind LY96 (Homo sapiens)
RHEA:39595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH = (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)
RHEA:41938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose
REACT:R-XTR-190681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in endoplasmic reticulum membrane (Xenopus tropicalis)
REACT:R-DRE-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
REACT:R-BTA-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Bos taurus)
REACT:R-GGA-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Gallus gallus)
GO:0099615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	R-2-hydroxyglutarate alpha-pyruvate transhydrogenase activity
GO:0099615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-2HG-pyruvate transhydrogenase activity
GO:0099615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity
RHEA:45832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH
RHEA:41913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-[ACP] + H(+) + NADPH => hexadecanoyl-[ACP] + NADP(+)
RHEA:12195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate
REACT:R-RNO-69562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Rattus norvegicus)
REACT:R-BTA-6805792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S291-PHF20 translocates to cytosol (Bos taurus)
REACT:R-RNO-5668417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Rattus norvegicus)
REACT:R-CEL-2534346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAM1 Binds Hyaluronic Acid (Caenorhabditis elegans)
REACT:R-CEL-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Caenorhabditis elegans)
REACT:R-GGA-8982617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB:O2 dissociates (Gallus gallus)
EC:3.6.1.60	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diadenosine hexaphosphate hydrolase (AMP-forming)"
EC:3.6.1.60	skos:prefLabel	"diadenosine hexaphosphate hydrolase (AMP-forming)"
GO:0047660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amidinoaspartase activity
GO:0047660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amidinoaspartic amidinohydrolase activity
GO:0047660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-amidino-L-aspartate amidinohydrolase activity
RHEA:10737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + NAD(+) => an aldehyde + H(+) + NADH
RHEA:28815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate(in) + H(+)(out) = 4-hydroxybenzoate(out) + H(+)(in)
RHEA:12795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP
REACT:R-GGA-8852298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Gallus gallus)
RHEA:11025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NH4(+) => ADP + 2 H(+) + phosphoramidate
RHEA:15376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	columbamine + S-adenosyl-L-methionine <=> H(+) + palmatine + S-adenosyl-L-homocysteine
REACT:R-BTA-352136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Bos taurus)
REACT:R-CFA-4084978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Canis familiaris)
GO:0043125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Neu/ErbB-2 receptor activity
GO:0043125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HER3 receptor binding
GO:0043125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ErbB-3 class receptor binding
REACT:R-DRE-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Danio rerio)
RHEA:45329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin => 7,8-dihydromonapterin
GO:0045027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA end binding
REACT:R-PFA-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Plasmodium falciparum)
RHEA:14791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine
RHEA:29269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine(out) + Na(+)(out) => L-valine(in) + Na(+)(in)
GO:0051498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syn-copalyl diphosphate synthase activity
GO:0051498	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	diterpene cyclase activity
REACT:R-SSC-158145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Sus scrofa)
RHEA:46245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-9009308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 polyubiquitinates RUNX2 (Homo sapiens)
REACT:R-CFA-2404134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4:atROL binds TTR (Canis familiaris)
REACT:R-XTR-6811472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IER3 recruits MAPKs to PP2A-B56-beta,gamma (Xenopus tropicalis)
RHEA:53608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + O2 = (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)
REACT:R-DRE-5685011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR activation at DNA DSBs (Danio rerio)
REACT:R-SCE-70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Saccharomyces cerevisiae)
GO:1903981	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	siderophore binding
GO:1903981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterochelin binding
GO:1903981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin binding
REACT:R-SSC-2064406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Sus scrofa)
REACT:R-DRE-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Danio rerio)
REACT:R-SCE-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Saccharomyces cerevisiae)
RHEA:70780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + NADP(+) => 6-dehydro-D-glucose + H(+) + NADPH
RHEA:39482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)
REACT:R-HSA-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Homo sapiens)
RHEA:57201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + L-arginyl-[protein] => N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]
REACT:R-CEL-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)
REACT:R-RNO-8873946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD3 deubiquitinates PTEN (Rattus norvegicus)
RHEA:30394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-glutamine <=> 2-oxoglutaramate + L-methionine
RHEA:64216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-L-lyxonate + H(+) = CO2 + L-lyxonate
REACT:R-DRE-3788745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL8 promoter (Danio rerio)
RHEA:18171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + pyruvate => 4-hydroxy-2-oxoglutarate
REACT:R-XTR-205262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Direct recruitment of PI3K to p-KIT (Xenopus tropicalis)
REACT:R-SSC-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Sus scrofa)
RHEA:62941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-acetylcytosine => acetate + cytosine + H(+)
REACT:R-MMU-170076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Mus musculus)
REACT:R-BTA-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Bos taurus)
REACT:R-CEL-382061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular processing of novel PDGFs (Caenorhabditis elegans)
REACT:R-HSA-1839095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BCR-pFGFR1 binds GRB2:GAB2 (Homo sapiens)
REACT:R-HSA-71515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)
RHEA:51646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + 2 H2O + NAD(+) => cholesterol + H(+) + NADH + O2
REACT:R-RNO-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Rattus norvegicus)
RHEA:59822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3'-diphosphate,5'-triphosphate + AMP => 2 ATP
REACT:R-HSA-110157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine (Homo sapiens)
REACT:R-GGA-450827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Gallus gallus)
GO:0050196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PR-enzyme
GO:0050196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylase phosphatase activity
GO:0050196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type 1 protein phosphatase activity
GO:0050196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylase a phosphohydrolase activity
GO:0050196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphorylase] phosphatase activity
GO:0050196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen phosphorylase phosphatase activity
GO:0050196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylase a phosphatase activity
GO:0050196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein phosphatase C
REACT:R-SCE-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Saccharomyces cerevisiae)
RHEA:67532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine
REACT:R-DME-3640861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 ubiquitinates ADP-ribosylated AXIN (Drosophila melanogaster)
REACT:R-HSA-5660622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1B gene is transcribed (Homo sapiens)
RHEA:59269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6)-methyl-L-lysyl-[protein] => AH2 + formaldehyde + L-lysyl-[protein]
RHEA:22084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate
REACT:R-MMU-2465924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1LW binds 11cRAL (Mus musculus)
RHEA:23464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase"
RHEA:23464	skos:altLabel	"N-acetylgalactosaminyltransferase I"
RHEA:23464	skos:prefLabel	"glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase"
RHEA:23464	skos:altLabel	"uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I"
RHEA:23464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RHEA:23464	skos:altLabel	"glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase"
GO:0047360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(isoprenyl)phosphate galactosephosphatetransferase activity
GO:0047360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	undecaprenyl phosphate galactosyl-1-phosphate transferase activity
GO:0047360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity
GO:0047360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(isoprenol)-phosphate galactose phosphotransferase activity
GO:0047360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(isoprenol)-phosphate galactosephosphotransferase activity
GO:0047360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyl-phosphate galactose phosphotransferase activity
RHEA:69259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + progoitrin <=> (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
REACT:R-SSC-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)
RHEA:18163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-CoA + CoA => acetyl-CoA + tetradecanoyl-CoA
RHEA:39991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine
REACT:R-CFA-8938356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RMB14 binds RUNX2 (Canis familiaris)
RHEA:25010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-212432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DRIP coactivator complex (Homo sapiens)
REACT:R-DME-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Drosophila melanogaster)
REACT:R-DRE-1678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses CS/HS precursor (Danio rerio)
REACT:R-SCE-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Saccharomyces cerevisiae)
RHEA:70462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate
REACT:R-HSA-5159245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)
RHEA:49096	skos:altLabel	"MPE cyclase"
RHEA:49096	skos:prefLabel	"anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase"
RHEA:49096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase"
RHEA:49096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine
RHEA:38222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
RHEA:34163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroquinone 1,2-dioxygenase"
RHEA:34163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone + O2 = (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)
RHEA:34163	skos:altLabel	"hydroquinone dioxygenase"
RHEA:34163	skos:prefLabel	"hydroquinone 1,2-dioxygenase"
REACT:R-MMU-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Mus musculus)
REACT:R-DDI-947535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Dictyostelium discoideum)
RHEA:52526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase]
RHEA:65608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + docosanoyl-CoA = CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine
REACT:R-XTR-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Xenopus tropicalis)
REACT:R-GGA-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Gallus gallus)
REACT:R-SSC-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Sus scrofa)
RHEA:38093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine => delta-tocotrienol + S-adenosyl-L-methionine
RHEA:70678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Met-enkephalin-Arg-Phe <=> L-arginyl-L-phenylalanine + Met-enkephalin
RHEA:63233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H(+) + NADH => NAD(+) + octanoyl-CoA
RHEA:18938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-homoserine lactone + H2O => a carboxylate + L-homoserine lactone
RHEA:35994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:34176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-CoA + malonyl-CoA => 4-hydroxycoumarin + CO2 + 2 CoA
GO:0050380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C55-isoprenyl diphosphatase activity
GO:0050380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	undecaprenyl-diphosphate phosphohydrolase activity
GO:0050380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyl-diphosphatase activity
GO:0050380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C(55)-isoprenyl diphosphatase activity
GO:0050380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C(55)-isoprenyl pyrophosphatase activity
GO:0050380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C55-isoprenyl pyrophosphatase activity
GO:0050380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoprenyl pyrophosphatase activity
REACT:R-MMU-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
RHEA:36771	skos:prefLabel	"GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase"
RHEA:36771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase"
RHEA:36771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
RHEA:34070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate <=> diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate
RHEA:61287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cystine + O2 <=> (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)
GO:0000900	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	translation repressor activity, nucleic acid binding
GO:0000900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA regulatory element binding translation repressor activity
GO:0000900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation repressor activity, mRNA regulatory element binding
REACT:R-CFA-437118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI stimulates PI3K beta, gamma (Canis familiaris)
REACT:R-CFA-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Canis familiaris)
REACT:R-SSC-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Sus scrofa)
RHEA:32082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-yl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate
RHEA:32575	skos:altLabel	"(+)-alpha-pinene cyclase"
RHEA:32575	skos:prefLabel	"(+)-alpha-pinene synthase"
RHEA:32575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-alpha-pinene synthase"
RHEA:32575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (1R,5R)-alpha-pinene + diphosphate
REACT:R-SSC-140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequestered tissue factor -> tissue factor (Sus scrofa)
REACT:R-DRE-389491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two NPFF receptors can bind neuropeptide FF (Danio rerio)
RHEA:29839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NADP(+) = 2-dehydro-L-idonate + H(+) + NADPH
RHEA:71050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + L-phenylalanine(out) <=> glycine(out) + L-phenylalanine(in)
REACT:R-HSA-190256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to FGF (Homo sapiens)
RHEA:71075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-cystine(out) = L-arginine(out) + L-cystine(in)
RHEA:27971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotriose + H2O => alpha-D-glucose + D-maltose
RHEA:20013	skos:altLabel	"carbamoylaspartotranskinase"
RHEA:20013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate
RHEA:20013	skos:altLabel	"aspartate transcarbamylase"
RHEA:20013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate carbamoyltransferase"
RHEA:20013	skos:altLabel	"ATCase"
RHEA:20013	skos:prefLabel	"aspartate carbamoyltransferase"
REACT:R-HSA-9636297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtpA binds TRIM27 (Homo sapiens)
REACT:R-DDI-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Dictyostelium discoideum)
REACT:R-MMU-5687284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMBT1 binds SFTPD 12mer, SFTPAs (Mus musculus)
RHEA:57768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrotoluene + NADH + O2 = 3-methylcatechol + NAD(+) + nitrite
RHEA:21677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dimethylallyl diphosphate => (R)-lavandulyl diphosphate + diphosphate
RHEA:17876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an R-cob(III)alamin(out) + ATP + H2O <=> ADP + an R-cob(III)alamin(in) + H(+) + phosphate
RHEA:62272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine
RHEA:25108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate
REACT:R-SSC-192097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Sus scrofa)
REACT:R-GGA-5654651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS3 (Gallus gallus)
RHEA:19263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + heme b(out) + phosphate => ATP + H2O + heme b(in)
RHEA:13527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]
REACT:R-MMU-5359451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from SAM to NAM to form MNA (Mus musculus)
RHEA:25644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-menthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH
REACT:R-SSC-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Sus scrofa)
REACT:R-DDI-5223313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Dictyostelium discoideum)
REACT:R-HSA-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)
REACT:R-GGA-2132261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor H binds to C3b (Gallus gallus)
RHEA:25159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + ATP + L-cysteine <=> AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
GO:0140110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription regulator activity
RHEA:63461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + GTP => (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)
REACT:R-HSA-111924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA catalytic subunit translocates to the nucleus (Homo sapiens)
REACT:R-SPO-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Schizosaccharomyces pombe)
RHEA:61924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4R)-ketoconazole(in) + ATP + H2O = (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate
RHEA:25674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol-4,5-bisphosphate 4-phosphatase"
RHEA:25674	skos:altLabel	"PtdIns-4,5-P2 4-phosphatase"
RHEA:25674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
RHEA:25674	skos:prefLabel	"phosphatidylinositol-4,5-bisphosphate 4-phosphatase"
RHEA:50122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosanoyl-taurine => taurine + tetracosanoyl-CoA
RHEA:67845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:25066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH
RHEA:63639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty acyl-AMP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + H(+)
GO:0008719	skos:altLabel	"D-erythro-7,8-dihydroneopterin triphosphate epimerase"
GO:0008719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroneopterin triphosphate 2'-epimerase"
GO:0008719	skos:prefLabel	"dihydroneopterin triphosphate 2'-epimerase"
GO:0008719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
GO:0008719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity
GO:0008719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroneopterin triphosphate 2'-epimerase activity
REACT:R-XTR-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Xenopus tropicalis)
REACT:R-CFA-8987202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Canis familiaris)
RHEA:70790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-citrulline(in) + L-ornithine(out) <=> H(+)(out) + L-citrulline(out) + L-ornithine(in)
RHEA:42458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zymosterol => 4alpha-methylzymosterol
REACT:R-DDI-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Dictyostelium discoideum)
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PRK
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribulokinase activity
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribulose phosphate kinase activity
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate + H(+)
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PRuK
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribulokinase (phosphorylating)
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphoribulose kinase activity
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribulokinase"
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKK
GO:0008974	skos:prefLabel	"phosphoribulokinase"
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribulose-5-phosphate kinase activity
GO:0008974	skos:altLabel	"phosphopentokinase"
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-ribulose-5-phosphate 1-phosphotransferase activity
GO:0008974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopentokinase activity
RHEA:70178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->4)-D-galactose + phosphate <=> alpha-D-glucose 1-phosphate + D-galactose
RHEA:45629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]
REACT:R-SSC-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Sus scrofa)
REACT:R-HSA-751013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (s) reassociates with G beta:gamma (Homo sapiens)
RHEA:63120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+)
REACT:R-DME-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Drosophila melanogaster)
RHEA:14854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoyl-CoA + H2O => 4-hydroxybenzoyl-CoA + chloride + H(+)
REACT:R-RNO-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Rattus norvegicus)
RHEA:20201	skos:prefLabel	"phenylalanine racemase (ATP-hydrolyzing)"
RHEA:20201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-phenylalanine = AMP + D-phenylalanine + diphosphate + H(+)
RHEA:20201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine racemase (ATP-hydrolyzing)"
RHEA:24404	skos:altLabel	"HMG-CoA lyase"
RHEA:24404	skos:prefLabel	"hydroxymethylglutaryl-CoA lyase"
RHEA:24404	skos:altLabel	"3-hydroxy-3-methylglutarate-CoA lyase"
RHEA:24404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxymethylglutaryl-CoA lyase"
RHEA:24404	skos:altLabel	"(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase"
RHEA:24404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
REACT:R-CFA-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Canis familiaris)
REACT:R-XTR-914182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 zeta binding allows recruitment of PI3K (Xenopus tropicalis)
RHEA:10958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + trans-2-coumarate => (E)-cinnamate + H(+) + NADPH + O2
REACT:R-RNO-8852809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPN, CPB2 cleave C3a, C5a (Rattus norvegicus)
RHEA:57236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GMP
RHEA:13714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + succinate => a ubiquinol + fumarate
RHEA:36913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA
REACT:R-SSC-177479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Axonal transport of NGF:Trk complexes (Sus scrofa)
REACT:R-PFA-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Plasmodium falciparum)
GO:0042610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD8 receptor binding
REACT:R-SSC-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Sus scrofa)
RHEA:60733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + perillyl aldehyde => 2 H(+) + NADPH + perillate
REACT:R-SCE-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Saccharomyces cerevisiae)
RHEA:59498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:23292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lombricine kinase"
RHEA:23292	skos:prefLabel	"lombricine kinase"
RHEA:23292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-lombricine = ADP + H(+) + N-phospho-L-lombricine
REACT:R-BTA-2454118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cRAL binds to opsin to form 11c-retinyl:RHO (Bos taurus)
REACT:R-SSC-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Sus scrofa)
REACT:R-MMU-5672083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KTN1 binds Kinesin-1 (Mus musculus)
REACT:R-CEL-77323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Caenorhabditis elegans)
REACT:R-MMU-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Mus musculus)
REACT:R-DME-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Drosophila melanogaster)
REACT:R-XTR-2424246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind lecticans (Xenopus tropicalis)
REACT:R-RNO-2309787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS2 (Rattus norvegicus)
REACT:R-CFA-5654623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS3 (Canis familiaris)
RHEA:61134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + H2O + kaempferol + succinate => (2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2
REACT:R-HSA-9701507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN6 dephosphorylates JAK3 (Homo sapiens)
REACT:R-CEL-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Caenorhabditis elegans)
REACT:R-RNO-9696179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Rattus norvegicus)
REACT:R-SSC-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Sus scrofa)
REACT:R-CFA-451056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Microtubule-independent trafficking of connexons to the plasma membrane (Canis familiaris)
RHEA:41017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol
REACT:R-HSA-375140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds promyogenic cadherins (Homo sapiens)
GO:0043797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity
GO:0043797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity
GO:0043797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceraldehyde-3-phosphate ferredoxin reductase activity
GO:0043797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GAPOR
GO:0043797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceraldehyde-3-phosphate Fd oxidoreductase activity
RHEA:55318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 3 NADH + sulfite => 3 H2O + hydrogen sulfide + 3 NAD(+)
REACT:R-HSA-180732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)
REACT:R-DRE-77590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CstF to the CPSF Bound Pre-mRNA (Danio rerio)
REACT:R-DRE-450971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Danio rerio)
RHEA:18116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + ATP <=> a ribonucleoside 5'-triphosphate + ADP
GO:0045015	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	HDEL receptor activity
GO:0045015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDEL sequence binding
RHEA:37832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate
REACT:R-DDI-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Dictyostelium discoideum)
REACT:R-DRE-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Danio rerio)
RHEA:29988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(in) + H(+)(in) => adenosine(out) + H(+)(out)
GO:0010471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-galactose:mannose-1-phosphate guanylyltransferase activity
GO:0010471	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GDP-L-galactose phosphorylase activity
GO:0010471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-L-galactose:mannose-1-phosphate guanylyltransferase activity
RHEA:37690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-GGA-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Gallus gallus)
RHEA:60080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)
RHEA:47937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + H2O + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH
RHEA:64711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + NADP(+) <=> butanal + H(+) + NADPH
REACT:R-MMU-6784204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind OSMR (Mus musculus)
RHEA:55544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine
REACT:R-SSC-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Sus scrofa)
GO:0031772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 orexin receptor binding
GO:0031772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OX2 orexin receptor binding
GO:0031772	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 hypocretin receptor ligand
GO:0031772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 hypocretin receptor binding
RHEA:61611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbB protein]-dithiol + a quinone <=> [DsbB protein]-disulfide + a quinol
RHEA:54894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide
RHEA:50783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octanal <=> (2E)-octenal + H(+) + NADPH
REACT:R-RNO-8851890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates SHC1-2 (Rattus norvegicus)
REACT:R-HSA-9629216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Homo sapiens)
REACT:R-HSA-8943083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP (Homo sapiens)
RHEA:38987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonanoyl-CoA + O2 = (2E)-nonenoyl-CoA + H2O2
RHEA:20030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxysarpagine + NADP(+) => H(+) + NADPH + vellosimine
REACT:R-XTR-210304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with PECAM1 (Xenopus tropicalis)
REACT:R-BTA-8931648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Bos taurus)
GO:0001064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T3/T7 type RNA polymerase activity
GO:0001064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single subunit type RNA polymerase activity
GO:0071551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP homotypic interaction motif binding
GO:0071551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHIM binding
RHEA:71578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphomethyl-dUMP in DNA + putrescine <=> 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate
REACT:R-DRE-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Danio rerio)
REACT:R-SSC-2473594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP15 (Sus scrofa)
REACT:R-CFA-9687828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-GlcNAcylation of RIPK3 (TLR4 signaling) (Canis familiaris)
REACT:R-RNO-1793186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Rattus norvegicus)
REACT:R-DME-159046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Drosophila melanogaster)
GO:0047856	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrocoumarin lactonohydrolase activity
GO:0047856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocoumarin lipase activity
GO:0047856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocoumarin hydrolase activity
REACT:R-DDI-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Dictyostelium discoideum)
REACT:R-BTA-981728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to membrane-associated C3b (Bos taurus)
REACT:R-BTA-109998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Bos taurus)
REACT:R-CFA-5661125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2sR4-HIST1H4 (Canis familiaris)
REACT:R-HSA-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Homo sapiens)
GO:0047773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-carnitinamide amidohydrolase activity
GO:0047773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitinamidase activity
GO:0047773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine amidase activity
GO:0047773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-carnitinamidase activity
GO:0047773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-carnitine amidase activity
RHEA:72388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + sulfate(in) => 2 hydrogencarbonate(in) + sulfate(out)
RHEA:14021	skos:prefLabel	"ecdysone 20-monooxygenase"
RHEA:14021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ecdysone + O2 = 20-hydroxyecdysone + A + H2O
RHEA:14021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ecdysone 20-monooxygenase"
GO:0010326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine-oxo-acid transaminase activity
REACT:R-DRE-6814094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds ARFIP2 (Danio rerio)
RHEA:28707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(in) = Cd(2+)(out)
RHEA:66328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine(out) = taurine(in)
REACT:R-CFA-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Canis familiaris)
REACT:R-RNO-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Rattus norvegicus)
REACT:R-CEL-9705794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 binds SRD5A2 inhibitors (Caenorhabditis elegans)
RHEA:42855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine <=> (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-427656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:43507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethylfurfural + O2 <=> 2,5-diformylfuran + H2O2
RHEA:40096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxohexacosanoate + H2O + NAD(+) => 2 H(+) + hexacosanedioate + NADH
RHEA:64394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dipeptide(in) + H(+)(in) => a dipeptide(out) + H(+)(out)
RHEA:72061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate(in) + 2 Na(+)(in) => glycochenodeoxycholate(out) + 2 Na(+)(out)
REACT:R-DME-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Drosophila melanogaster)
REACT:R-HSA-216048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens)
REACT:R-CFA-195378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of VEGF proteins (Canis familiaris)
REACT:R-DRE-109415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)
RHEA:50698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:42674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-hercynylcysteine S-oxide + H2O => gamma-L-glutamyl-L-cysteine + hercynine + O2
RHEA:23297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aceneuramate => N-acetyl-D-mannosamine + pyruvate
REACT:R-DME-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Drosophila melanogaster)
EC:3.2.1.98	skos:altLabel	"exo-maltohexaohydrolase"
EC:3.2.1.98	skos:altLabel	"G6-amylase"
EC:3.2.1.98	skos:prefLabel	"glucan 1,4-alpha-maltohexaosidase"
EC:3.2.1.98	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan 1,4-alpha-maltohexaosidase"
EC:3.2.1.98	skos:altLabel	"maltohexaose-producing amylase"
RHEA:44544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(out) + ATP + H2O = a fatty acid(in) + ADP + H(+) + phosphate
REACT:R-CFA-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Canis familiaris)
RHEA:12542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-alanyl-tRNA(Ala) => ATP + L-alanine + tRNA(Ala)
REACT:R-DRE-6788855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3KRP phosphorylates PsiAm, RibAm (Danio rerio)
REACT:R-BTA-5693536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDC1 (Bos taurus)
REACT:R-GGA-8987223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10RB binds TYK2 (Gallus gallus)
REACT:R-SSC-9769235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGED1 binds NPAS4 (Sus scrofa)
REACT:R-XTR-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Xenopus tropicalis)
RHEA:30310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine
RHEA:34581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + H2O + pentalenolactone F + 2 succinate => 2 2-oxoglutarate + 2 O2 + pentalenolactone D
RHEA:67795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleotidyl-uridine-RNA <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA
REACT:R-CFA-3229181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALM1:Ca2+ binds CNG channel (Canis familiaris)
REACT:R-HSA-1980118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB mediates NOTCH1 ubiquitination (Homo sapiens)
REACT:R-HSA-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Homo sapiens)
REACT:R-HSA-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)
REACT:R-DME-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Drosophila melanogaster)
EC:3.4.24.66	skos:prefLabel	"choriolysin L"
EC:3.4.24.66	skos:altLabel	"teleost hatching enzyme"
EC:3.4.24.66	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choriolysin L"
EC:3.4.24.66	skos:altLabel	"low choriolytic enzyme"
REACT:R-HSA-983421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Journey of cargo through Golgi complex (Homo sapiens)
REACT:R-HSA-174427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)
REACT:R-DME-1676164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Drosophila melanogaster)
REACT:R-RNO-8857555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates GPNMB (Rattus norvegicus)
REACT:R-SCE-6807866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the ERGIC (Saccharomyces cerevisiae)
REACT:R-XTR-9033959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Xenopus tropicalis)
REACT:R-XTR-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Xenopus tropicalis)
RHEA:23653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-glutaminyl-[peptide] => N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)
REACT:R-RNO-3788075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by ADAMTS4, ADAMTS5 (Rattus norvegicus)
RHEA:17151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an organic molecule + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DDI-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Dictyostelium discoideum)
REACT:R-CFA-6808566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHGA-derived peptide binds the bacterial cell surface (Canis familiaris)
REACT:R-SSC-4641256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated AXIN is degraded by the proteasome (Sus scrofa)
RHEA:39503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)
REACT:R-SSC-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Sus scrofa)
REACT:R-SCE-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Saccharomyces cerevisiae)
GO:0047632	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	agmatine amidinohydrolase
GO:0047632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	agmatine iminohydrolase activity
GO:0047632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine deiminase activity
REACT:R-XTR-5687758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP4C:PPP4R2 dephosphorylates RPA2 (Xenopus tropicalis)
RHEA:23857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Hg + NADP(+) => Hg(2+) + NADPH
RHEA:67956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-chloropropanoate + H2O = (R)-lactate + chloride + H(+)
RHEA:60619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine <=> ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate
REACT:R-MMU-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Mus musculus)
RHEA:36443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochanoclavine-I aldehyde = 6,8-dimethyl-6,7-didehydroergoline + H2O
RHEA:27692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dGTP => ATP + dGDP
EC:3.4.21.109	skos:altLabel	"membrane-type serine protease 1"
EC:3.4.21.109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"matriptase"
EC:3.4.21.109	skos:prefLabel	"matriptase"
EC:3.4.21.109	skos:altLabel	"serine protease 14"
EC:3.4.21.109	skos:altLabel	"MT-SP1"
EC:3.4.21.109	skos:altLabel	"tumor-associated differentially-expressed gene 15 protein"
EC:3.4.21.109	skos:altLabel	"epithin"
EC:3.4.21.109	skos:altLabel	"serine endopeptidase SNC19"
EC:3.4.21.109	skos:altLabel	"prostamin"
EC:3.4.21.109	skos:altLabel	"serine protease TADG-15"
REACT:R-CEL-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Caenorhabditis elegans)
REACT:R-RNO-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Rattus norvegicus)
REACT:R-SSC-4093331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras:GTP binds p120-RasGAP (Sus scrofa)
RHEA:36596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + NADP(+) => NADPH + sulfur
GO:0140771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]
GO:0140771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP-dependent peptidyl-lysine N6-palmitoyltransferase activity
RHEA:30037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + CO2 + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH + O2
GO:0102501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructuronate reductase activity
REACT:R-MMU-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Mus musculus)
REACT:R-DME-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Drosophila melanogaster)
REACT:R-DRE-5216234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)
RHEA:25165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + butanoyl-CoA => (2E)-butenoyl-CoA + AH2
REACT:R-CFA-9796387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Canis familiaris)
REACT:R-GGA-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Gallus gallus)
REACT:R-XTR-9733545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids bind ALB (Xenopus tropicalis)
RHEA:13026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]
GO:0030785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RuBisCO LSMT activity
GO:0030785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity
GO:0030785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity
GO:0030785	skos:altLabel	"RuBisCO methyltransferase"
GO:0030785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity
GO:0030785	skos:prefLabel	"[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase"
GO:0030785	skos:altLabel	"RuBisCO LSMT"
GO:0030785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity
GO:0030785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RuBisCO methyltransferase activity
GO:0030785	skos:altLabel	"ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase"
GO:0030785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity
GO:0030785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine
GO:0030785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity
GO:0030785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase"
REACT:R-XTR-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Xenopus tropicalis)
REACT:R-GGA-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Gallus gallus)
REACT:R-HSA-5682084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Homo sapiens)
REACT:R-RNO-391375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Rattus norvegicus)
REACT:R-HSA-1306876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 activation by small molecules (Homo sapiens)
GO:0016496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	substance P receptor activity
REACT:R-XTR-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Xenopus tropicalis)
RHEA:71007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + L-tryptophan(in) = L-phenylalanine(in) + L-tryptophan(out)
RHEA:66985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + H2O => CoA + H(+) + isovalerate
REACT:R-CFA-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Canis familiaris)
REACT:R-DRE-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Danio rerio)
REACT:R-MMU-2045911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
REACT:R-BTA-2160492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4I1:FAD oxidises L-Phe to kPPV (Bos taurus)
REACT:R-RNO-6810472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT13 hydrolyses AP6A to AP4 and ADP (Rattus norvegicus)
REACT:R-SSC-2301205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 monomethylates histone H4 (Sus scrofa)
RHEA:25905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	futalosine + H2O => dehypoxanthine futalosine + hypoxanthine
RHEA:24156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"branched-chain-fatty-acid kinase"
RHEA:24156	skos:prefLabel	"branched-chain-fatty-acid kinase"
RHEA:24156	skos:altLabel	"isobutyrate kinase"
RHEA:24156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP
RHEA:15725	skos:altLabel	"1,5-anhydro-D-arabino-hex-2-ulose dehydratase"
RHEA:15725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,5-anhydro-D-fructose dehydratase"
RHEA:15725	skos:altLabel	"AF dehydratase"
RHEA:15725	skos:altLabel	"1,5-anhydro-D-fructose 4-dehydratase"
RHEA:15725	skos:altLabel	"1,5-anhydro-D-fructose hydrolyase"
RHEA:15725	skos:prefLabel	"1,5-anhydro-D-fructose dehydratase"
RHEA:15725	skos:altLabel	"AFDH"
RHEA:15725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose = ascopyrone M + H2O
REACT:R-HSA-5218642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Homo sapiens)
REACT:R-MMU-9645501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)
REACT:R-XTR-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Xenopus tropicalis)
GO:0018495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity
REACT:R-XTR-159790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)
RHEA:57701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine
RHEA:62757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-GGA-9014434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GAPs stimulate RHOG GTPase activity (Gallus gallus)
REACT:R-RNO-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Rattus norvegicus)
REACT:R-CEL-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Caenorhabditis elegans)
RHEA:61493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + an ultra-long-chain fatty acyl-CoA => an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)
REACT:R-XTR-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Xenopus tropicalis)
REACT:R-RNO-879584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO3A1 isoform 1 has abroad substrate specificity (Rattus norvegicus)
REACT:R-HSA-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Homo sapiens)
RHEA:28812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxo-L-gulonate(in) + Na(+)(in) => 2,3-dioxo-L-gulonate(out) + Na(+)(out)
EC:3.4.24.81	skos:prefLabel	"ADAM10 endopeptidase"
EC:3.4.24.81	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADAM10 endopeptidase"
EC:3.4.24.81	skos:altLabel	"Kuzbanian protein"
EC:3.4.24.81	skos:altLabel	"myelin-associated disintegrin metalloproteinase"
REACT:R-RNO-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Rattus norvegicus)
GO:0071813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoprotein particle binding
GO:0071813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	plasma lipoprotein binding
GO:0071813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoprotein binding
GO:0071813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasma lipoprotein particle binding
REACT:R-CEL-549241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:28316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baicalin + UDP => baicalein + UDP-alpha-D-glucuronate
REACT:R-HSA-2022378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Homo sapiens)
RHEA:66684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]
REACT:R-RNO-4084989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Rattus norvegicus)
RHEA:59931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythritol + NADP(+) <=> D-erythrose + H(+) + NADPH
RHEA:52743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyphosate + H2O + O2 <=> aminomethylphosphonate + glyoxylate + H(+) + H2O2
RHEA:48123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 + H2O <=> ganglioside GM3 + N-acetylneuraminate
RHEA:48216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:65302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + succinate + verruculide A => 2-oxoglutarate + chrodrimanin C + O2
RHEA:50628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-(omega-methylsulfanyl)alkylmalate = a 3-(omega-methylsulfanyl)alkylmalate
GO:0052682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming) activity
GO:0052682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epi-cedrol synthase activity
GO:0052682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-epicedrol synthase activity
GO:0052682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epicedrol synthase activity
RHEA:32210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-2-hydroxyhexa-2,4-dienedioate <=> (3Z)-2-oxohex-3-enedioate
RHEA:47743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate <=> CO2 + demethylphylloquinone + diphosphate
GO:0140320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pattern recognition receptor decoy activity
GO:0140320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAMP receptor decoy activity
GO:0140320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pathogen-associated molecular pattern receptor decoy activity
RHEA:42368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]
RHEA:42368	skos:prefLabel	"dihydromonacolin L hydroxylase"
RHEA:42368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydromonacolin L hydroxylase"
RHEA:18878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + S-adenosyl-L-methionine => 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-77263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Bos taurus)
REACT:R-DME-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Drosophila melanogaster)
REACT:R-RNO-167419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex releases GDP (Rattus norvegicus)
REACT:R-HSA-193533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Homo sapiens)
REACT:R-PFA-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Plasmodium falciparum)
RHEA:67492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)
REACT:R-DRE-5656070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFBPs bind FGFs (Danio rerio)
REACT:R-GGA-9700200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)
RHEA:65084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-77319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Xenopus tropicalis)
RHEA:62369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(out) + 2 hydrogencarbonate(out) => Fe(2+)(in) + 2 hydrogencarbonate(in)
GO:1990460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leptin receptor binding
RHEA:22470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate => GTP + 3 H2O
RHEA:20126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-5340320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTP transports GSL from plasma membrane to ER membrane (Mus musculus)
REACT:R-HSA-9626060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)
REACT:R-HSA-9635609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rv3655c binds RNF213 (Homo sapiens)
REACT:R-CFA-5610766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Canis familiaris)
REACT:R-DME-8964614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Drosophila melanogaster)
RHEA:59358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + lactobionate => H2O + lactobiono-1,5-lactone
RHEA:64431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-proline(out) + H(+)(out) <=> glycyl-L-proline(in) + H(+)(in)
RHEA:60153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-L-glutamyl-[protein] + H2O => L-glutamate + L-glutamyl-[protein]
RHEA:62553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosylceramide + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP
REACT:R-HSA-391905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxoeicosanoid receptor can bind oxoeicosanoid (Homo sapiens)
REACT:R-RNO-164834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enzyme-bound ATP is released (Rattus norvegicus)
RHEA:56352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)
REACT:R-CFA-6814671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of late-endosome derived vesicles at the TGN (Canis familiaris)
REACT:R-SSC-8878054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 (Sus scrofa)
RHEA:70739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-6786124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3,STAT6 bind p-Y-IL4R (Homo sapiens)
GO:0102137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxateasterone synthase activity
REACT:R-HSA-5655244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 point and translocation mutants bind PLCG1 (Homo sapiens)
REACT:R-CFA-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Canis familiaris)
RHEA:68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoate + H(+) + NADPH => AMP + butanal + diphosphate + NADP(+)
REACT:R-DDI-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Dictyostelium discoideum)
RHEA:45985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)
GO:0004525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease III activity
GO:0004525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease 3 activity
GO:0004525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pre-mRNA 3'-end processing endonuclease
GO:0004525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase III activity
RHEA:68238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + Na(+)(out) => L-glutamine(in) + Na(+)(in)
GO:0015231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyltetrahydrofolate transmembrane transporter activity
GO:0015231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyltetrahydrofolate transporter activity
RHEA:22977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate
REACT:R-RNO-5654587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS phosphorylates PPTN11 (Rattus norvegicus)
REACT:R-HSA-909721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ISGF3 complex to nucleus (Homo sapiens)
RHEA:36896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O
REACT:R-CFA-9709842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS binds TOMM70 (Canis familiaris)
REACT:R-DRE-6794347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 dimerizes (Danio rerio)
REACT:R-RNO-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Rattus norvegicus)
RHEA:58047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + alpha,alpha-trehalose <=> 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA
GO:0017041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity
GO:0017041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ceramidetrihexoside alpha-galactosidase activity
GO:0017041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ceramidetrihexosidase activity
GO:0017041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trihexosylceramide alpha-galactosidase activity
GO:0017041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ceramide trihexosidase activity
GO:0017041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trihexosyl ceramide galactosidase activity
GO:0017041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosylgalactosylglucosylceramidase activity
REACT:R-CFA-5665989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIAPH1 binds RHOA:GTP (Canis familiaris)
REACT:R-HSA-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Homo sapiens)
RHEA:31863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"friedelin synthase"
RHEA:31863	skos:prefLabel	"friedelin synthase"
RHEA:31863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = friedelin
RHEA:35032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine(in) => L-serine(out)
REACT:R-GGA-4411402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NLK (Gallus gallus)
RHEA:39265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + NADP(+) => (2E,13Z)-docosadienoyl-CoA + H(+) + NADPH
RHEA:63664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH = H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)
REACT:R-GGA-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Gallus gallus)
RHEA:46893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate
REACT:R-MMU-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Mus musculus)
REACT:R-GGA-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Gallus gallus)
RHEA:61324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sucrose = alpha-D-glucose + beta-D-fructose
RHEA:54856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + octan-3-one = ethyl hexanoate + H2O + NADP(+)
REACT:R-MMU-202703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD47 binds SIRP (Mus musculus)
REACT:R-GGA-421515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uroporphyrinogen III => coproporphyrinogen III + 4 CO2 (Gallus gallus)
REACT:R-MMU-6788556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to NDUFV1, V2 (Mus musculus)
REACT:R-XTR-449087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD4 binds Interleukin-16 (Xenopus tropicalis)
REACT:R-RNO-75244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL binds FAS Receptor (Rattus norvegicus)
RHEA:10436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O
RHEA:10436	skos:altLabel	"BA7 alpha dehydratase"
RHEA:10436	skos:prefLabel	"bile-acid 7alpha-dehydratase"
RHEA:10436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bile-acid 7alpha-dehydratase"
REACT:R-BTA-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Bos taurus)
GO:0004561	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-alpha-glucosaminidase activity
GO:0004561	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-2-acetamido-2-deoxyglucosidase activity
GO:0004561	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity
GO:0004561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-acetylglucosaminidase activity
GO:0004561	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAG activity
GO:0004561	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-acetylglucosaminidase activity
GO:0004561	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-alpha-D-glucosaminidase activity
REACT:R-RNO-193064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3-like proteins reducde ANDST to TEST (Rattus norvegicus)
RHEA:61604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-dithiol + [DsbB protein]-disulfide = [DsbA protein]-disulfide + [DsbB protein]-dithiol
REACT:R-BTA-5423038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Bos taurus)
RHEA:50055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurocholate(in) <=> ADP + H(+) + phosphate + taurocholate(out)
RHEA:67932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + desmosterol(in) + H2O = ADP + desmosterol(out) + H(+) + phosphate
RHEA:24471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dimethylaniline + NADPH + O2 <=> H2O + N,N-dimethylaniline N-oxide + NADP(+)
RHEA:23584	skos:prefLabel	"dihydrofolate synthase"
RHEA:23584	skos:altLabel	"7,8-dihydrofolate synthetase"
RHEA:23584	skos:altLabel	"dihydrofolate synthetase"
RHEA:23584	skos:altLabel	"DHFS"
RHEA:23584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate
RHEA:23584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrofolate synthase"
RHEA:23584	skos:altLabel	"H2-folate synthetase"
REACT:R-MMU-5688294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT5 deacetylates Cytochrome C (Mus musculus)
REACT:R-DRE-9678561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Danio rerio)
REACT:R-CFA-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Canis familiaris)
REACT:R-SSC-8948224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)
RHEA:37977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate => H(+) + homogentisate + phytyl diphosphate
REACT:R-MMU-5632668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMO translocates to the cilium (Mus musculus)
REACT:R-BTA-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Bos taurus)
RHEA:29596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NADP(+) + sulfoacetaldehyde => H(+) + NADPH + sulfoacetyl-CoA
REACT:R-CFA-5654165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR1 (Canis familiaris)
RHEA:14388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphate + H2O <=> a dolichyl phosphate + H(+) + phosphate
REACT:R-RNO-427514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC deacetylates histone H3 (Rattus norvegicus)
RHEA:46552	skos:prefLabel	"acyl-lipid Delta(12)-acetylenase"
RHEA:46552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46552	skos:altLabel	"Delta12 fatty acid acetylenase"
RHEA:46552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid Delta(12)-acetylenase"
RHEA:20088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA
REACT:R-HSA-9032402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FRS3 (Homo sapiens)
REACT:R-MMU-159733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor X to factor X (Mus musculus)
RHEA:68716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + germacrene D
REACT:R-DME-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Drosophila melanogaster)
RHEA:45288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 = 2-glyceryl-prostaglandin G2
REACT:R-SSC-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Sus scrofa)
GO:0042896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chloramphenicol transporter activity
GO:0042896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloramphenicol transmembrane transporter activity
REACT:R-HSA-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Homo sapiens)
REACT:R-BTA-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Bos taurus)
REACT:R-RNO-83723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Rattus norvegicus)
REACT:R-HSA-9026891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2 activates RAS signaling through SHC1 (Homo sapiens)
GO:0047663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoglycoside-6-N-acetyltransferase activity
GO:0047663	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	kanamycin 6'-N-acetyltransferase activity
GO:0047663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6'-aminoglycoside-N-acetyltransferase activity
GO:0047663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside N6'-acetyltransferase activity
GO:0047663	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetyl-CoA:kanamycin-B N6'-acetyltransferase activity
GO:0047663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside 6'-N-acetyltransferase activity
GO:0047663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AAC(6') activity
GO:0047663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoglycoside-6'-acetyltransferase activity
REACT:R-HSA-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Homo sapiens)
REACT:R-SSC-9013108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOC (Sus scrofa)
RHEA:50931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate
GO:0008671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-3-deoxygalactonate kinase activity
GO:0008671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-galactonokinase activity
GO:0008671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxygalactonokinase activity
GO:0008671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygalactonate kinase (phosphorylating)
GO:0008671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity
GO:0008671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygalactonokinase activity
REACT:R-CEL-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Caenorhabditis elegans)
REACT:R-HSA-9673349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5 binds FZD7 (Homo sapiens)
RHEA:35176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	novobiocin(in) => novobiocin(out)
RHEA:55315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-RNO-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Rattus norvegicus)
RHEA:11807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + H2O + NAD(+) <=> an aromatic carboxylate + 2 H(+) + NADH
RHEA:16390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 H(+) + NADH + O2 => CO2 + H2O + hydroquinone + NAD(+)
REACT:R-RNO-388900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurotensin receptors can bind neurotensins (Rattus norvegicus)
RHEA:48036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + H2O = globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine
REACT:R-SSC-8850794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK5 (Sus scrofa)
REACT:R-DME-389622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)
REACT:R-HSA-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Homo sapiens)
REACT:R-RNO-177671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Rattus norvegicus)
REACT:R-BTA-2247513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1:ligand is endocytosed (Bos taurus)
GO:0042294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	URM1 transferase activity
REACT:R-BTA-158941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Bos taurus)
REACT:R-DDI-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Dictyostelium discoideum)
REACT:R-CFA-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Canis familiaris)
REACT:R-XTR-212222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 recruits DNA methyltransferases (Xenopus tropicalis)
REACT:R-GGA-112042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid binds MOR (Gallus gallus)
REACT:R-MMU-2018659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Mus musculus)
REACT:R-GGA-3662335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates histone H2A, H2B, H3, H4 (Gallus gallus)
REACT:R-CEL-3928598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of p190RhoGEF to p-FAK (Caenorhabditis elegans)
RHEA:70355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-carboxybiuret + H(+) = biuret + CO2
RHEA:18094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + NADP(+) => H(+) + NADPH + uracil
REACT:R-DRE-5607002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor VIIIa (Danio rerio)
RHEA:29952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + uridine(in) => H(+)(out) + uridine(out)
REACT:R-RNO-8854051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL18 ubiquitinates FBXL7 (Rattus norvegicus)
REACT:R-MMU-5252041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Mus musculus)
RHEA:34126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7-trioxododecanoyl-CoA <=> CoA + H(+) + olivetolate
REACT:R-BTA-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Bos taurus)
REACT:R-DRE-1483096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA is dephosphorylated to ETA by PHOSPHO1 (Danio rerio)
REACT:R-XTR-4085217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Xenopus tropicalis)
REACT:R-CFA-6807565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY is transferred to the phagosome (Canis familiaris)
REACT:R-XTR-5665748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds RHOC:GTP (Xenopus tropicalis)
REACT:R-RNO-6784399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Rattus norvegicus)
RHEA:40120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecanoyl-CoA => CoA + H(+) + tetradecanoate
REACT:R-BTA-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Bos taurus)
REACT:R-BTA-996727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST recruits the BHC complex (Bos taurus)
RHEA:35872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:25114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + pyridoxine => H2O + pyridoxine 5'-phosphate
REACT:R-BTA-9011981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 is recruited to MYC and BCL2 genes (Bos taurus)
REACT:R-XTR-5654147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PLCG1 (Xenopus tropicalis)
REACT:R-HSA-1655852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Lathosterol Oxidase (SC5D, SC5DL) (Homo sapiens)
REACT:R-CEL-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Caenorhabditis elegans)
REACT:R-MMU-1475026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (cytosol) (Mus musculus)
REACT:R-MMU-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Mus musculus)
REACT:R-DRE-9708866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-F2R binds vorapaxar (Danio rerio)
REACT:R-DDI-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Dictyostelium discoideum)
RHEA:55360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol = 9-cis-retinol
REACT:R-HSA-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Homo sapiens)
REACT:R-BTA-8948219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3 binds Lysyl hydroxylated collagen propeptides (Bos taurus)
RHEA:14158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triphosphate => diphosphate + phosphate
RHEA:28020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine => enterobactin + 3 H2O
RHEA:58129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:30203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = 2 GDP + 2 H(+)
RHEA:63855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 <=> (2R)-2-hydroperoxydodecanoate
RHEA:48547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine <=> [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine
RHEA:52568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:49547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)
REACT:R-HSA-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Homo sapiens)
RHEA:49073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene + 2 FMNH2 + 2 O2 => dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O
RHEA:51386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoyl-serotonin => hexadecanoyl-CoA + serotonin
RHEA:68662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate
REACT:R-HSA-9665405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 ECD mutants bind trastuzumab (Homo sapiens)
RHEA:30896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + propane-1,3-diamine => 3-aminopropanal + H2O2 + NH4(+)
REACT:R-RNO-1482571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)
REACT:R-RNO-5218804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK activation by VEGFR (Rattus norvegicus)
GO:0030565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA pseudouridylation guide activity
REACT:R-XTR-8953917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Xenopus tropicalis)
RHEA:34373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + NH4(+) => H2O + indole-3-acetamide
REACT:R-CFA-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Canis familiaris)
REACT:R-DRE-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Danio rerio)
RHEA:17182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + FMNH2 + O2 => a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu
REACT:R-RNO-990489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-13 is a dimer (Rattus norvegicus)
REACT:R-SPO-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
REACT:R-CFA-8941543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Canis familiaris)
RHEA:54774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide
REACT:R-RNO-183067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Localization of CBL:GRB2 to the membrane (Rattus norvegicus)
REACT:R-GGA-5686587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates RAD52 (Gallus gallus)
REACT:R-MMU-9688831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK3 at K55, K363 (Mus musculus)
GO:0050577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)
GO:0050577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-L-fucose synthase activity
GO:0050577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-fucose synthetase activity
GO:0050577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity
RHEA:18033	skos:altLabel	"benzoate-p-hydroxylase"
RHEA:18033	skos:prefLabel	"benzoate 4-monooxygenase"
RHEA:18033	skos:altLabel	"p-hydroxybenzoate hydroxylase"
RHEA:18033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:18033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzoate 4-monooxygenase"
RHEA:18033	skos:altLabel	"CYP53A1"
RHEA:18033	skos:altLabel	"benzoate-para-hydroxylase"
RHEA:18033	skos:altLabel	"benzoic acid 4-hydroxylase"
RHEA:18033	skos:altLabel	"benzoate 4-hydroxylase"
EC:3.4.24.6	skos:prefLabel	"leucolysin"
EC:3.4.24.6	skos:altLabel	"Leucostoma neutral proteinase"
EC:3.4.24.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leucolysin"
RHEA:70930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate(in) + H(+)(in) <=> (R)-glycerate(out) + H(+)(out)
RHEA:59223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)
REACT:R-HSA-5617820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of IFT B complex (Homo sapiens)
RHEA:42034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2
GO:0047464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C-5 uronosyl epimerase activity
GO:0047464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucuronyl C-5 epimerase activity
GO:0047464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity
GO:0047464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparosan-N-sulfate-glucuronate 5-epimerase activity
GO:0047464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyglucuronate epimerase activity
GO:0047464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparosan-N-sulphate-glucuronate 5-epimerase activity
GO:0047464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparosan epimerase activity
GO:0047464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity
RHEA:10004	skos:prefLabel	"thiocyanate isomerase"
RHEA:10004	skos:altLabel	"isothiocyanate isomerase"
RHEA:10004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl isothiocyanate = benzyl thiocyanate
RHEA:10004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiocyanate isomerase"
RHEA:43295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
RHEA:29929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate(out) + Na(+)(out) => (R)-pantothenate(in) + Na(+)(in)
GO:0030757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity
GO:0030757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 7-O-methyltransferase activity
GO:0030757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methylquercetin 7-O-methyltransferase activity
GO:0030757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylquercitin 7-O-methyltransferase activity
GO:0030757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 7-methyltransferase activity
GO:0030757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity
GO:0030757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-OMT activity
RHEA:42088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(out) + oxalate(in) <=> formate(in) + oxalate(out)
REACT:R-RNO-166795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Classical C3 convertase (C4b:C2a complex) (Rattus norvegicus)
RHEA:56009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
REACT:R-DRE-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Danio rerio)
REACT:R-CFA-8854044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)
REACT:R-SSC-6801195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3 binds BNIP3L (Sus scrofa)
RHEA:31386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> lupeol
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-NPDase activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-nucleotide phosphodiesterase activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exonuclease I activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphodiesterase activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-PDE activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphodiesterase I activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkaline phosphodiesterase activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDE I activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligonucleate 5'-nucleotidohydrolase activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orthophosphoric diester phosphohydrolase activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleotide pyrophosphatase/phosphodiesterase I activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-phosphodiesterase activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'NPDE activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-PDase activity
GO:0004528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-exonuclease activity
REACT:R-PFA-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Plasmodium falciparum)
REACT:R-DRE-8952044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Danio rerio)
RHEA:44381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-demethylubiquinol + S-adenosyl-L-methionine => a ubiquinol + H(+) + S-adenosyl-L-homocysteine
GO:0008818	skos:prefLabel	"adenosylcobinamide-GDP ribazoletransferase"
GO:0008818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalamin 5'-phosphate synthase activity
GO:0008818	skos:altLabel	"cobalamin synthase"
GO:0008818	skos:altLabel	"cobalamin (5'-phosphate) synthase"
GO:0008818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)
GO:0008818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)
GO:0008818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylcobinamide-GDP ribazoletransferase"
GO:0008818	skos:altLabel	"cobalamin-5'-phosphate synthase"
REACT:R-CEL-1482546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)
REACT:R-BTA-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
REACT:R-RNO-8850539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GNB5:RGS dimers from CCT/TRiC (Rattus norvegicus)
REACT:R-DRE-981497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Danio rerio)
REACT:R-HSA-180630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of APOBEC3G with Gag (Homo sapiens)
REACT:R-RNO-8855825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTRA1 hydrolyzes ACAN (Aggrecan) (Rattus norvegicus)
REACT:R-MMU-4551655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Mus musculus)
GO:0102043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyl phosphate kinase activity
REACT:R-HSA-8944047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JUN binds the PTEN gene promoter (Homo sapiens)
REACT:R-XTR-1878002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLTs transfer Xyl to core protein (Xenopus tropicalis)
REACT:R-GGA-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Gallus gallus)
RHEA:42065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP => 2',3'-cGAMP + 2 diphosphate
REACT:R-SSC-71050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of the FASL:FAS receptor complex (Sus scrofa)
REACT:R-CEL-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Caenorhabditis elegans)
REACT:R-BTA-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Bos taurus)
REACT:R-GGA-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Gallus gallus)
REACT:R-SSC-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Sus scrofa)
RHEA:58822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CO2 + Na(+)(out) => H(+) + malonate + Na(+)(in)
RHEA:65168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + preaustinoid A = A + H2O + preaustinoid A1
RHEA:20365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoethanolamine + S-adenosyl-L-methionine = H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
GO:0080068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity
RHEA:72012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(in) + urate(out) => glutathione(out) + urate(in)
REACT:R-BTA-2002460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB binds Collagen chains (Bos taurus)
RHEA:34750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine + ATP <=> 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)
RHEA:42001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP
REACT:R-MMU-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Mus musculus)
REACT:R-RNO-8938951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PAX5 (BSAP) (Rattus norvegicus)
REACT:R-SSC-8938913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF1 (Sus scrofa)
RHEA:44472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine
GO:0047130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
GO:0047130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity
GO:0047130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
GO:0047130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
GO:0047130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)
GO:0047130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine-alpha-ketoglutarate reductase activity
REACT:R-SSC-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Sus scrofa)
REACT:R-RNO-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Rattus norvegicus)
REACT:R-RNO-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Rattus norvegicus)
RHEA:60977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-en-1-ol + NAD(+) => (E)-4-hydroxynon-2-enal + H(+) + NADH
REACT:R-BTA-1296043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of HCN channels (Bos taurus)
REACT:R-MMU-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
REACT:R-SSC-2046298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to a branch of keratan (Sus scrofa)
RHEA:44223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxypentadecanoate + ATP + CoA <=> 15-hydroxypentadecanoyl-CoA + AMP + diphosphate
REACT:R-XTR-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Xenopus tropicalis)
REACT:R-HSA-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Homo sapiens)
RHEA:52767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O <=> (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate
RHEA:18721	skos:prefLabel	"ent-13-epi-manoyl oxide synthase"
RHEA:18721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-13-epi-manoyl oxide synthase"
RHEA:18721	skos:altLabel	"ent-LDPP synthase"
RHEA:18721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = diphosphate + ent-13-epi-manoyl oxide
REACT:R-GGA-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Gallus gallus)
RHEA:43662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + methylmalonyl-CoA + phosphate => ATP + hydrogencarbonate + propanoyl-CoA
RHEA:24253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ADP + 2 H(+)
GO:0033778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
GO:0033778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HCO 12alpha-hydroxylase activity
GO:0033778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
GO:0033778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity
GO:0033778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity
GO:0033778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP12
GO:0033778	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sterol 12alpha-hydroxylase activity
RHEA:44417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)
REACT:R-MMU-114697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Mus musculus)
RHEA:46382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-4839734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN mutants destabilize the destruction complex (Homo sapiens)
GO:0102878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate
GO:0102878	skos:prefLabel	"(+)-alpha-barbatene synthase"
GO:0102878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-barbatene synthase activity
GO:0102878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-alpha-barbatene synthase"
REACT:R-HSA-9673794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL:RAC1:GTP binds NOX1 complex (Homo sapiens)
REACT:R-DRE-750993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (q) reassociates with G beta:gamma (Danio rerio)
RHEA:72690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol(out) <=> all-trans-retinol(in)
RHEA:62013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:55056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase"
RHEA:55056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:55056	skos:altLabel	"CYP94C1"
RHEA:55056	skos:prefLabel	"12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase"
REACT:R-XTR-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Xenopus tropicalis)
RHEA:60371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urate(out) <=> urate(in)
GO:0050750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-density lipoprotein receptor binding
GO:0050750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL receptor binding
GO:0050750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-density lipoprotein particle receptor binding
GO:0005340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide-sulphate transporter activity
GO:0005340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide-sulfate transmembrane transporter activity
RHEA:10894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH => (2R,3S)-3-isopropylmalate + NAD(+)
REACT:R-SSC-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Sus scrofa)
REACT:R-RNO-205321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of KIT and sSCF (Rattus norvegicus)
RHEA:45987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)
REACT:R-SSC-8848658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Sus scrofa)
REACT:R-CEL-8874202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)
REACT:R-HSA-9674131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)
REACT:R-HSA-3000348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)
REACT:R-RNO-8936851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHRR binds ARNT (Rattus norvegicus)
REACT:R-RNO-373071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR7 binds CCL19 and 21 ligands (Rattus norvegicus)
REACT:R-CEL-72127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal B Complex (Caenorhabditis elegans)
REACT:R-SCE-5690042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Saccharomyces cerevisiae)
GO:0008718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-amino-acid:acceptor oxidoreductase (deaminating)
GO:0008718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-amino-acid:(acceptor) oxidoreductase (deaminating)
GO:0008718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-amino-acid dehydrogenase activity
REACT:R-MMU-391377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone receptor can bind LH (Mus musculus)
RHEA:64075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O
REACT:R-GGA-187828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p21 to the nucleus (Gallus gallus)
REACT:R-SSC-5625797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Sus scrofa)
REACT:R-BTA-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Bos taurus)
REACT:R-MMU-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Mus musculus)
RHEA:19722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Danio rerio)
REACT:R-MMU-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Mus musculus)
GO:0098918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of synapse
REACT:R-HSA-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)
RHEA:36868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:27579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N-tert-butylpiperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + tert-butylamine
REACT:R-RNO-2404134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4:atROL binds TTR (Rattus norvegicus)
RHEA:29730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethane-1-sulfonate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + sulfite
RHEA:52389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-threonate => 4-O-phospho-D-threonate + ADP + H(+)
REACT:R-DDI-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Dictyostelium discoideum)
REACT:R-MMU-170847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
REACT:R-RNO-9734535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Rattus norvegicus)
RHEA:30152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + NADP(+) => FAD + 2 H(+) + NADPH
REACT:R-BTA-141439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of activated MAD2 from kinetochores (Bos taurus)
REACT:R-CFA-417825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y11 receptor can bind to ATP (Canis familiaris)
GO:0047262	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity
GO:0047262	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity
GO:0047262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polygalacturonate 4-alpha-galacturonosyltransferase activity
GO:0047262	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity
REACT:R-DDI-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Dictyostelium discoideum)
RHEA:19953	skos:prefLabel	"alanine--oxo-acid transaminase"
RHEA:19953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-alanine = an L-alpha-amino acid + pyruvate
RHEA:19953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alanine--oxo-acid transaminase"
RHEA:19953	skos:altLabel	"alanine--oxo-acid aminotransferase"
RHEA:51664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-5-phenylhydantoin + H2O = H(+) + N-carbamoyl-D-phenylglycine
REACT:R-XTR-9708866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-F2R binds vorapaxar (Xenopus tropicalis)
RHEA:10693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 => H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone
RHEA:70091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + o-quinone methide = hydroxyclavatol ethyl ether
REACT:R-DDI-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Dictyostelium discoideum)
RHEA:30094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + D-alanine + H2O <=> a ubiquinol + NH4(+) + pyruvate
REACT:R-MMU-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Mus musculus)
GO:0106211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate
GO:0106211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity
GO:0106211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-InsP4 activity
GO:0106211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate diphosphatase activity
GO:0106211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphosphoinositol 1,3,4,6-tetrakisphosphate diphosphatase activity
RHEA:62732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide D + FADH2
REACT:R-XTR-9664855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Xenopus tropicalis)
REACT:R-CFA-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Canis familiaris)
REACT:R-MMU-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Mus musculus)
EC:1.1.1.358	skos:prefLabel	"2-dehydropantolactone reductase"
EC:1.1.1.358	skos:altLabel	"2-dehydropantoyl-lactone reductase"
EC:1.1.1.358	skos:altLabel	"2-ketopantoyl lactone reductase"
EC:1.1.1.358	skos:altLabel	"ketopantoyl lactone reductase"
EC:1.1.1.358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydropantolactone reductase"
EC:1.1.1.358	skos:altLabel	"2-oxopantoyl lactone reductase"
GO:0050738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructosyltransferase activity
REACT:R-DDI-74885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCYs converts GTP to cGMP (Dictyostelium discoideum)
RHEA:29410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)
RHEA:33919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + lanosterol + NADPH = 24,25-dihydrolanosterol + NADP(+)
RHEA:50058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycocholate(out) + H(+) + phosphate => ATP + glycocholate(in) + H2O
REACT:R-GGA-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Gallus gallus)
REACT:R-MMU-448963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of MyoD:E protein with MEF2 (Mus musculus)
RHEA:47088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH
REACT:R-GGA-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Gallus gallus)
RHEA:29252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + Na(+)(in) => 2 H(+)(in) + Na(+)(out)
REACT:R-BTA-6785607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCM binds FAAP24 (Bos taurus)
REACT:R-SSC-2395992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,4S-IRF3 is dimerized (Sus scrofa)
REACT:R-BTA-5654423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Bos taurus)
RHEA:48128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + H(+) + phosphate
REACT:R-CFA-442273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)
RHEA:67983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-zeacarotene <=> 7,8-dihydro-beta-carotene
RHEA:66029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine => (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
REACT:R-BTA-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
RHEA:47025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)
REACT:R-DME-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Drosophila melanogaster)
REACT:R-GGA-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Gallus gallus)
REACT:R-CFA-9009309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STUB1 (Canis familiaris)
REACT:R-HSA-8855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR:DAB1 binds SH3KBP1 (Homo sapiens)
RHEA:19255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + H(+) + phosphocholine => a sphingomyelin + H2O
RHEA:70379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-3-oxosphinganine
REACT:R-HSA-9023348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds DLL1 gene promoter (Homo sapiens)
RHEA:58848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-hydroxygeranial + H(+) + NADH
REACT:R-RNO-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Rattus norvegicus)
REACT:R-HSA-9018825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 GEFs activate RHOT2 (Homo sapiens)
REACT:R-SSC-374173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR1 (Sus scrofa)
REACT:R-SPO-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Schizosaccharomyces pombe)
REACT:R-SCE-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Saccharomyces cerevisiae)
REACT:R-HSA-1855160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus (Homo sapiens)
REACT:R-DME-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
RHEA:20280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an N-hydroxyarylamine <=> an N-acetoxyarylamine + CoA
RHEA:47411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O <=> (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA
GO:0018517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phthalate 4,5-cis-dihydrodiol dehydrogenase activity
GO:0018517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity
REACT:R-HSA-202704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaXbeta2 binds JAM3 (Homo sapiens)
GO:0015483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acid transporting porin activity
REACT:R-HSA-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)
REACT:R-SPO-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)
RHEA:56323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose <=> an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP
RHEA:39129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+)
REACT:R-BTA-166817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by C3 convertases (Bos taurus)
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine 5-phosphoribosylpyrophosphate amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl pyrophosphate amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylpyrophosphate glutamyl amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-phosphoribosylpyrophosphate amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphororibosyl-1-pyrophosphate amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine phosphoribosyldiphosphate amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphoribosyl-1-pyrophosphate amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyldiphosphate 5-amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amidophosphoribosyltransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribose pyrophosphate amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity
GO:0004044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine phosphoribosylpyrophosphate amidotransferase activity
REACT:R-CFA-176609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + PAPS => cholesterol sulfate + PAP (Canis familiaris)
REACT:R-XTR-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Xenopus tropicalis)
RHEA:17985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-trimethylammoniobutyraldehyde dehydrogenase"
RHEA:17985	skos:prefLabel	"4-trimethylammoniobutyraldehyde dehydrogenase"
RHEA:17985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH
REACT:R-BTA-983424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of COPII coated vesicle (Bos taurus)
REACT:R-HSA-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Homo sapiens)
REACT:R-MMU-1678843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein translation regulator 4EHP (Mus musculus)
REACT:R-GGA-202394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CARMA1 to Plasma membrane (Gallus gallus)
REACT:R-HSA-2002440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen C-propeptides (Homo sapiens)
REACT:R-HSA-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Homo sapiens)
REACT:R-DRE-1112602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Danio rerio)
REACT:R-DRE-9753285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)
GO:0008508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bile acid:sodium symporter activity
GO:0008508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/bile acid symporter activity
RHEA:32661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeranial + 2 H(+) + 2 NADPH => (6E)-8-hydroxygeraniol + 2 NADP(+)
RHEA:13199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-6-sulfoquinovose => H(+) + sulfite + UDP-alpha-D-glucose
REACT:R-RNO-8849348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Rattus norvegicus)
REACT:R-GGA-8874208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Gallus gallus)
RHEA:48537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O => 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)
REACT:R-MMU-5653974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator binds Rag dimers (Mus musculus)
REACT:R-SPO-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)
GO:0000257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrilase activity
GO:0000257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzonitrilase activity
GO:0000257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrile aminohydrolase activity
GO:0000257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetonitrilase activity
RHEA:62214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-879221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSTPIP1 binds Pyrin (Xenopus tropicalis)
REACT:R-XTR-380508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NuMA to the centrosomes (Xenopus tropicalis)
REACT:R-MMU-5676593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Mus musculus)
REACT:R-SPO-8876454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND3 exchanges GTP for GDP on RAB12 (Schizosaccharomyces pombe)
RHEA:49378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0050115	skos:altLabel	"myosin light-chain kinase phosphatase"
GO:0050115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin light chain kinase phosphatase activity
GO:0050115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin-light-chain phosphatase activity
GO:0050115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin-light-chain-phosphatase activity
GO:0050115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin light-chain kinase phosphatase activity
GO:0050115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[myosin-light-chain] phosphatase"
GO:0050115	skos:altLabel	"myosin phosphatase"
GO:0050115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Myosin light-chain]-phosphatase activity
GO:0050115	skos:prefLabel	"[myosin-light-chain] phosphatase"
GO:0050115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein phosphatase 2A
GO:0050115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin-light-chain-phosphate phosphohydrolase activity
GO:0008741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulokinase activity
GO:0008741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulokinase activity
GO:0008741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:L(or D)-ribulose 5-phosphotransferase activity
GO:0008741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribulokinase (phosphorylating)
REACT:R-HSA-3790137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Stimulation of IL8 transcription in senescent cells (Homo sapiens)
REACT:R-DDI-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)
RHEA:23798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + norajmaline => 17-O-acetylnorajmaline + H2O
REACT:R-DRE-391937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP/CysLT receptor can bind cysteinyl leukotrienes (Danio rerio)
REACT:R-HSA-354073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PTK2 at Y397 (Homo sapiens)
REACT:R-DDI-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)
RHEA:15406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) => [(3R)-hydroxybutanoate](n+1) + CoA
RHEA:44318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + glycerol + H(+) => 1-dodecanoylglycerol + H2O
REACT:R-GGA-5635861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH binds GLI1 (Gallus gallus)
REACT:R-DME-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Drosophila melanogaster)
RHEA:49463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-aminomuconate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)
REACT:R-DRE-1562640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LNK binds to p-KIT and inhibit downstream signaling (Danio rerio)
REACT:R-DDI-374909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabolism of Noradrenaline (Dictyostelium discoideum)
REACT:R-DRE-6811411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the Golgi (Danio rerio)
EC:3.1.23.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Site specific endodeoxyribonucleases: cleavage is sequence specific"
EC:3.1.23.-	skos:prefLabel	"Site specific endodeoxyribonucleases: cleavage is sequence specific"
RHEA:39476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O
REACT:R-RNO-5687091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 binds MAPKAPK5 (Rattus norvegicus)
RHEA:64334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + nicotinyl-CoA => ATP + CoA + nicotinate
REACT:R-SSC-2327909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN binds collagen I, II, III, VI fibrils (Sus scrofa)
RHEA:56798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)alamin-[corrinoid adenosyltransferase]
RHEA:15059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + holo-[ACP] => (9Z)-octadecenoyl-[ACP] + H2O
REACT:R-CFA-139920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tBID to mitochondria (Canis familiaris)
REACT:R-RNO-389759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)
REACT:R-SSC-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Sus scrofa)
REACT:R-HSA-2317387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)
REACT:R-RNO-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Rattus norvegicus)
RHEA:46773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-416559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Rho-GTP by p190RhoGAP (Sus scrofa)
RHEA:45238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-MMU-8985929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Mus musculus)
RHEA:41728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:62444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-canavanine + L-ornithine = H(+) + L-arginine + L-canaline
RHEA:66734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in)
REACT:R-HSA-8857577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 facilitates PTK6 autophosphorylation (Homo sapiens)
REACT:R-CEL-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Caenorhabditis elegans)
REACT:R-BTA-5672969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF (Bos taurus)
REACT:R-RNO-203156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-derived TREM-1 ligand binds to TREM-1 (Rattus norvegicus)
RHEA:10413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + H2O => AMP + D-ribose 5-phosphate + 2 H(+)
RHEA:34586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + pentalenolactone D <=> CO2 + H2O + pentalenolactone E + succinate
EC:2.1.1.200	skos:altLabel	"TrMet(Xm32)"
EC:2.1.1.200	skos:prefLabel	"tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase"
EC:2.1.1.200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase"
REACT:R-MMU-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Mus musculus)
REACT:R-DRE-2473184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follistatin (FST) binds Activin (Danio rerio)
REACT:R-HSA-193099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPROG to ANDST (Homo sapiens)
GO:0033130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine receptor binding
REACT:R-BTA-202344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)
RHEA:68429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutein + O2 => (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone
REACT:R-SSC-141310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Sus scrofa)
RHEA:20826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + AMP + H(+) => adenosine + ATP
REACT:R-SSC-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Sus scrofa)
REACT:R-SCE-162742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)
REACT:R-DME-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Drosophila melanogaster)
REACT:R-DME-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Drosophila melanogaster)
RHEA:57889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + 5 H(+)(in) + NADH => a quinol + 4 H(+)(out) + NAD(+)
RHEA:64340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one = 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate
RHEA:71595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + succinate(in) = 2-oxoglutarate(in) + succinate(out)
RHEA:13760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-desulfoglucotropeolin + UDP
REACT:R-SSC-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Sus scrofa)
REACT:R-RNO-2730862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of LYN kinase (Rattus norvegicus)
REACT:R-XTR-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)
REACT:R-MMU-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Mus musculus)
REACT:R-HSA-9623059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1 binds POMC gene promoter (Homo sapiens)
REACT:R-RNO-374680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 trans-homophilic interaction (Rattus norvegicus)
RHEA:49129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine
REACT:R-HSA-9694665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)
RHEA:30246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 L-ascorbate + O2 <=> 2 H2O + 4 monodehydro-L-ascorbate radical
RHEA:58187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + 2 phytyl diphosphate <=> (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)
REACT:R-HSA-373087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR6 binds CCL20 ligand (Homo sapiens)
RHEA:47782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 25S rRNA + S-adenosyl-L-methionine
REACT:R-CFA-266051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HpETE is dehydrated to LTA4 by ALOX5 (Canis familiaris)
RHEA:35368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH => isoheptadecanoyl-coA + NADP(+)
RHEA:45151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)acryloyl-CoA + H2O <=> 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA
REACT:R-XTR-5218809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Xenopus tropicalis)
REACT:R-DRE-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Danio rerio)
REACT:R-SSC-8866283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBB recruits GPCRs into clathrin-coated pits (Sus scrofa)
RHEA:28507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->6)-lipid IVA + ATP => 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)
REACT:R-MMU-9034053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Mus musculus)
REACT:R-SCE-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Saccharomyces cerevisiae)
REACT:R-DDI-3149518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)
RHEA:33601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2
RHEA:58785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 => a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate
RHEA:33790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-ketolactose + H2O <=> 3-keto-beta-D-galactose + beta-D-glucose
REACT:R-HSA-3315483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4 (Homo sapiens)
RHEA:55202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine => 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
REACT:R-BTA-5669158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF2 binds PAK1 (Bos taurus)
RHEA:57351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methyl-L-kynurenine + H2O <=> 3-hydroxy-4-methylanthranilate + H(+) + L-alanine
REACT:R-BTA-216064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha8beta1 with Tenascin-C (Bos taurus)
REACT:R-RNO-200326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CK octamer] (Rattus norvegicus)
RHEA:56747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate
REACT:R-GGA-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Gallus gallus)
RHEA:49633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)
REACT:R-HSA-9012268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)
REACT:R-CEL-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Caenorhabditis elegans)
REACT:R-GGA-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Gallus gallus)
REACT:R-DRE-9733403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds PCSK9 inhibitors (Danio rerio)
RHEA:28192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine + NH4(+) => 2'-deoxyadenosine + H(+) + H2O
RHEA:11474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + formaldehyde + H2O2 => an N-methyl-L-amino acid + H2O + O2
REACT:R-RNO-514604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Rattus norvegicus)
REACT:R-DME-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Drosophila melanogaster)
GO:0050039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propanediol dehydrogenase activity
GO:0050039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-1,2-propanediol dehydrogenase activity
GO:0050039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactaldehyde reductase (NADPH) activity
GO:0050039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
GO:0050039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-propanediol:NADP+ oxidoreductase activity
GO:0050039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propane-1,2-diol:NADP+ oxidoreductase activity
GO:0015417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled polyamine transmembrane transporter activity
GO:0015417	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	spermidine porter activity
GO:0015417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type polyamine transporter activity
GO:0015417	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATPase-coupled spermidine transmembrane transporter activity
GO:0015417	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	polyamine-importing ATPase activity
GO:0015417	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	polyamine ABC transporter
GO:0015417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyamine-transporting ATPase activity
GO:0015417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent polyamine transmembrane transporter activity
GO:0015417	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	spermidine-importing ATPase activity
GO:0015417	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyamine porter activity
REACT:R-XTR-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Xenopus tropicalis)
REACT:R-RNO-419001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Rattus norvegicus)
REACT:R-BTA-3323050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNRD2 catalyzes the reduction of TXN2 by NADPH (Bos taurus)
REACT:R-HSA-873951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1:HSP90 binds inactive NLRP3 (Homo sapiens)
REACT:R-XTR-2327738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Xenopus tropicalis)
REACT:R-BTA-75238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL binds TRAIL receptors (Bos taurus)
REACT:R-SSC-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Sus scrofa)
RHEA:56391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
RHEA:36676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octacosanoyl-CoA + sphinganine => CoA + H(+) + N-(octacosanoyl)-sphinganine
REACT:R-GGA-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Gallus gallus)
REACT:R-CFA-199404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40L binds CD40 (Canis familiaris)
REACT:R-MMU-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Mus musculus)
REACT:R-SSC-1358801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds RNF41 ubiquitin ligase (Sus scrofa)
REACT:R-SSC-5692764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 binds CCND3 (Sus scrofa)
REACT:R-GGA-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Gallus gallus)
REACT:R-HSA-5682311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCA12 does not transport lipids from cytosol to extracellular region (Homo sapiens)
RHEA:66666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + coproporphyrin III(out) + H(+) + phosphate => ATP + coproporphyrin III(in) + H2O
RHEA:66260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + IC-asc-C7-AMP = AMP + H(+) + IC-asc-C7-CoA
REACT:R-DRE-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Danio rerio)
REACT:R-HSA-1462023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-pro-defensins are cleaved to remove the signal peptide (Homo sapiens)
RHEA:12438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-caffeoylputrescine => (E)-caffeoyl-CoA + putrescine
REACT:R-XTR-8875568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 activates RAP1 (Xenopus tropicalis)
RHEA:40747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysine + O2 = (3S)-3-hydroxy-L-lysine + CO2 + succinate
RHEA:50626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+) => acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O
REACT:R-HSA-8950340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Homo sapiens)
REACT:R-GGA-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Gallus gallus)
REACT:R-SSC-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Sus scrofa)
RHEA:34229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite => 5-nitrosalicylate + O2
REACT:R-GGA-158118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Gallus gallus)
REACT:R-HSA-3465545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)
REACT:R-CFA-139897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAD displaces tBID from BCL-2 sequestration (Canis familiaris)
RHEA:23325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-phospho-[ligated tRNA] + NAD(+) => ADP-beta-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide
RHEA:72640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine => 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine
REACT:R-HSA-9663194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some pathogenic BRCA1 mutants do not bind BARD1 (Homo sapiens)
REACT:R-XTR-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Xenopus tropicalis)
REACT:R-DRE-141156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL-mediated dimerization of procaspase-8 (Danio rerio)
REACT:R-MMU-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)
RHEA:15086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine
RHEA:43658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP
REACT:R-RNO-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
REACT:R-RNO-8847995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERBB2 binds PTK6 (BRK) (Rattus norvegicus)
RHEA:46693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + H(+) => 4-hydroxybenzoyl-5'-AMP + diphosphate
REACT:R-GGA-5685953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates RBBP8 (Gallus gallus)
RHEA:24215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(2-hydroxyethyl)-4-methylthiazole + ATP <=> 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)
REACT:R-CFA-4641350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TOP2A with SUMO2,3 (Canis familiaris)
REACT:R-MMU-9605700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Mus musculus)
RHEA:65855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(1)-steroid + H2O <=> a 1-hydroxy-3-oxo steroid
REACT:R-CFA-5694435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 and MIA3 load procollagen VII into COPII vesicles (Canis familiaris)
RHEA:16738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)
REACT:R-DME-193052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione isomerizes to progesterone (Drosophila melanogaster)
REACT:R-HSA-4839746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)
REACT:R-DME-3000120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLIF binds RCbl (Drosophila melanogaster)
REACT:R-RNO-9035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysS248-MPST:TXN2 dissociates (Rattus norvegicus)
RHEA:15239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c2] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome c2] + NADPH
REACT:R-MMU-9647619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD forms ring‐shaped oligomers  (Mus musculus)
RHEA:13780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate + NH4(+) <=> 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate
REACT:R-HSA-9036061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GLB1 does not hydrolyse linker chain(2) (Homo sapiens)
REACT:R-DRE-4551616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RPA1 (RPA70) with SUMO2,3 (Danio rerio)
RHEA:44713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + H2O => a 1-acylglycerol + a fatty acid + H(+)
RHEA:10614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose
RHEA:21683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxyphytanate + O2 <=> 2-oxophytanate + H2O2
REACT:R-DRE-8950405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Danio rerio)
REACT:R-SCE-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Saccharomyces cerevisiae)
RHEA:61336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + protoporphyrin IX(in) = ADP + H(+) + phosphate + protoporphyrin IX(out)
RHEA:48425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP
REACT:R-MMU-5212679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3A binds Me2sR4-HIST1H4 (Mus musculus)
REACT:R-CEL-4332359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active calmodulin binds CAMK2 (Caenorhabditis elegans)
REACT:R-SPO-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Schizosaccharomyces pombe)
REACT:R-DDI-9020251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)
RHEA:38053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA
RHEA:72549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + taurocholate(in) => 2-oxoglutarate(in) + taurocholate(out)
RHEA:16652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-445064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by VAV2 (Rattus norvegicus)
RHEA:26476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + L-rhamnopyranose => beta-D-galactosyl-(1->4)-L-rhamnose + phosphate
REACT:R-RNO-374214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CXCR4 and 7 bind CXCL12 ligand (Rattus norvegicus)
RHEA:36155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + Co(II)-factor III + S-adenosyl-L-methionine = A + Co-precorrin-4 + S-adenosyl-L-homocysteine
RHEA:36155	skos:prefLabel	"cobalt-factor III methyltransferase"
RHEA:36155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobalt-factor III methyltransferase"
RHEA:29205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + H2O + menaquinone-8 => dimethyl sulfoxide + menaquinol-8
REACT:R-MMU-1370500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR binds SCF beta-TrCP complex (Mus musculus)
RHEA:40699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol = 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-DME-209303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGS transports from the nucleus to the cytosol (Drosophila melanogaster)
RHEA:18990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-valine => 2-methylpropan-1-amine + CO2
REACT:R-CFA-196126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from cytosol to mitochondrial intermembrane space (Canis familiaris)
REACT:R-BTA-8937613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHBP binds CRH (Bos taurus)
REACT:R-DME-5675433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)
REACT:R-RNO-977317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Rattus norvegicus)
REACT:R-RNO-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Rattus norvegicus)
REACT:R-MMU-173512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Mus musculus)
REACT:R-HSA-2395223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyridinoline cross-links (Homo sapiens)
RHEA:22820	skos:prefLabel	"xylosyl alpha-1,3-xylosyltransferase"
RHEA:22820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:22820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylosyl alpha-1,3-xylosyltransferase"
RHEA:68383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + L-asparagine <=> 2-oxosuccinamate + L-serine
RHEA:42327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) <=> 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:17431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxocyclohexanecarboxylate + H(+) + NADH => NAD(+) + trans-4-hydroxycyclohexanecarboxylate
REACT:R-BTA-203774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Csk with PAG (Bos taurus)
REACT:R-GGA-2731141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds fibronectin (Gallus gallus)
RHEA:30500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-valine => (E)-2-methylpropanal oxime + CO2 + H2O
RHEA:11321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-beta-L-arabinopyranose => UDP-alpha-D-xylose
REACT:R-HSA-9715356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brigatinib-resistant ALK mutants don't bind brigatinib (Homo sapiens)
REACT:R-CFA-6799777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind PPP1R13B or TP53BP2 (Canis familiaris)
RHEA:38662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)
RHEA:21610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine => isoliquiritigenin + S-adenosyl-L-methionine
REACT:R-HSA-1247668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A binds O2, releasing H+ and CO2 (Homo sapiens)
REACT:R-DRE-6781922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds UFD1L:SKP2 (Danio rerio)
RHEA:51879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate <=> desmethylxanthohumol + diphosphate
RHEA:18081	skos:prefLabel	"pentalenene synthase"
RHEA:18081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pentalenene synthase"
RHEA:18081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + pentalenene
RHEA:18081	skos:altLabel	"pentalenene synthetase"
REACT:R-BTA-140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS1 (Bos taurus)
REACT:R-SSC-2046084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Sus scrofa)
RHEA:62176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-glucose + H2O = alpha-D-glucose 1-phosphate + GMP + 2 H(+)
RHEA:28074	skos:prefLabel	"sulfopropanediol 3-dehydrogenase"
RHEA:28074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (2R)-3-sulfolactate + 3 H(+) + 2 NADH
RHEA:28074	skos:altLabel	"dihydroxypropanesulfonate 3-dehydrogenase"
RHEA:28074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfopropanediol 3-dehydrogenase"
REACT:R-DRE-435244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM1 is phosphorylated (Danio rerio)
RHEA:19387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + raucaffricine + UDP => UDP-alpha-D-glucose + vomilenine
REACT:R-MMU-6786101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4 binds IL4R:JAK2 (Mus musculus)
RHEA:40148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + H2O => CoA + eicosanoate + H(+)
REACT:R-CEL-749446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Caenorhabditis elegans)
REACT:R-DME-1483002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to 1-acyl GO3P by GNPAT (Drosophila melanogaster)
REACT:R-BTA-2187358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters unphosphorylated SMAD2/3 (Bos taurus)
REACT:R-PFA-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Plasmodium falciparum)
REACT:R-GGA-749454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gi complex dissociates (Gallus gallus)
GO:0008399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthalene hydroxylase activity
GO:0008399	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2F2
REACT:R-BTA-9706350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates CBL (Bos taurus)
REACT:R-SPO-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Schizosaccharomyces pombe)
REACT:R-XTR-4341070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PPARA with SUMO1 (Xenopus tropicalis)
RHEA:18705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP
REACT:R-RNO-9641109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Rattus norvegicus)
REACT:R-RNO-8874079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated MET (Rattus norvegicus)
RHEA:20892	skos:altLabel	"phosphotransbutyrylase"
RHEA:20892	skos:prefLabel	"phosphate butyryltransferase"
RHEA:20892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphate butyryltransferase"
RHEA:20892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + phosphate = butanoyl phosphate + CoA
REACT:R-BTA-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Bos taurus)
RHEA:20259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyleneoxindole + H(+) + NADPH => 3-methyloxindole + NADP(+)
REACT:R-HSA-4722133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Homo sapiens)
GO:0018789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexylsulfamate sulfamidase activity
GO:0018789	skos:prefLabel	"cyclamate sulfohydrolase"
GO:0018789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclamate sulfamatase activity
GO:0018789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexylsulfamate sulfohydrolase activity
GO:0018789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclamate sulphohydrolase activity
GO:0018789	skos:altLabel	"cyclamate sulfamatase"
GO:0018789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexylsulfamate + H2O = cyclohexylamine + sulfate
GO:0018789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclamate sulfohydrolase"
GO:0018789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclamate sulfohydrolase activity
GO:0018789	skos:altLabel	"cyclamate sulfamidase"
GO:0018789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclamate sulfamidase activity
REACT:R-SSC-9661432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds ALB (Sus scrofa)
GO:0015591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose transmembrane transporter activity
RHEA:32709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-bornyl diphosphate => (2E)-geranyl diphosphate
RHEA:36079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine
RHEA:53551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin J2 <=> Delta(12)-prostaglandin J2
REACT:R-GGA-9756134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Gallus gallus)
RHEA:11720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-methylhydantoinase (ATP-hydrolyzing)"
RHEA:11720	skos:altLabel	"N-methylhydantoin amidohydrolase"
RHEA:11720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 2 H2O + N-methylhydantoin = ADP + 2 H(+) + N-carbamoylsarcosine + phosphate
RHEA:11720	skos:prefLabel	"N-methylhydantoinase (ATP-hydrolyzing)"
REACT:R-MMU-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Mus musculus)
REACT:R-RNO-266051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HpETE is dehydrated to LTA4 by ALOX5 (Rattus norvegicus)
RHEA:14246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O => AMP + diphosphate + H(+)
REACT:R-SSC-2002466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of allysine by LOX (Sus scrofa)
RHEA:38464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA
RHEA:28820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate(in) + H(+)(in) => 5-dehydro-D-gluconate(out) + H(+)(out)
REACT:R-RNO-83793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Rattus norvegicus)
REACT:R-MMU-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Mus musculus)
RHEA:40753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate => (9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate
REACT:R-HSA-6802910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
REACT:R-CFA-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Canis familiaris)
REACT:R-DRE-74247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Danio rerio)
REACT:R-SSC-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Sus scrofa)
REACT:R-SSC-1676204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Sus scrofa)
REACT:R-BTA-72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of eIF4E from the inactive eIF4E:4E-BP complex  (Bos taurus)
REACT:R-DRE-2168897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP1 (CD91) binds Hemopexin:heme (Danio rerio)
REACT:R-DME-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Drosophila melanogaster)
REACT:R-HSA-191072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Cx43 (Homo sapiens)
REACT:R-HSA-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Homo sapiens)
RHEA:25033	skos:altLabel	"NADP(H)-dependent retinol dehydrogenase/reductase"
RHEA:25033	skos:prefLabel	"NADP-retinol dehydrogenase"
RHEA:25033	skos:altLabel	"retinol dehydrogenase [NADP(+)]"
RHEA:25033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADP-retinol dehydrogenase"
RHEA:25033	skos:altLabel	"all-trans retinal reductase"
RHEA:25033	skos:altLabel	"all-trans-retinol dehydrogenase"
RHEA:25033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH
REACT:R-MMU-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Mus musculus)
GO:0050178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylpyruvate keto-enol-isomerase activity
GO:0050178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylpyruvate keto--enol tautomerase activity
GO:0050178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylpyruvate tautomerase activity
GO:0050178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylpyruvic keto--enol isomerase activity
GO:0106321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(hydroxymethyl)glutathione dehydrogenase NADP activity
REACT:R-MMU-5218818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Mus musculus)
REACT:R-SSC-2161951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)
RHEA:59438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate => 4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein]
REACT:R-CFA-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Canis familiaris)
REACT:R-SSC-202714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD58 binds CD2 (Sus scrofa)
REACT:R-MMU-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Mus musculus)
REACT:R-HSA-391866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of FAK by Src kinase (Homo sapiens)
REACT:R-XTR-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Xenopus tropicalis)
RHEA:53589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D2 => 16-oxoresolvin D2 + H(+) + NADH
REACT:R-MMU-8865454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX3 (Mus musculus)
REACT:R-HSA-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)
REACT:R-DDI-1475414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Dictyostelium discoideum)
RHEA:21541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5-phospho-beta-D-ribosyl)anthranilate => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
REACT:R-HSA-9614423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO1 (Homo sapiens)
REACT:R-SSC-433131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC1 co-transports dicarboxylic acids and a sodium ion (Sus scrofa)
GO:0035312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-3' exodeoxyribonuclease activity
RHEA:71957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + 3 Na(+)(in) => glutarate(out) + 3 Na(+)(out)
RHEA:44521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:12430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + NAD(+) => 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH
RHEA:45876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-DRE-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Danio rerio)
RHEA:65863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + Delta(1)-dihydrotestosterone + H2O <=> 17beta-hydroxyandrostan-1,3-dione + AH2
REACT:R-SSC-5205661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is recruited from the cytoplasm to the mitochondria (Sus scrofa)
RHEA:39843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA
REACT:R-BTA-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Bos taurus)
RHEA:50438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E1 => prostaglandin H1
REACT:R-HSA-6797993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 and CREBBP bind BNIP3L gene (Homo sapiens)
REACT:R-XTR-71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Xenopus tropicalis)
REACT:R-XTR-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Xenopus tropicalis)
RHEA:36425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine
REACT:R-MMU-159826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Mus musculus)
REACT:R-MMU-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Mus musculus)
REACT:R-SCE-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)
RHEA:22510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + DNA(n+1) => a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n)
REACT:R-MMU-5610737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH bind and ubiquitnate GLI1 (Mus musculus)
REACT:R-HSA-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Homo sapiens)
GO:0031812	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P2Y1 nucleotide receptor ligand
GO:0031812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y1 nucleotide receptor binding
RHEA:27763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H2O => CMP + diphosphate + H(+)
RHEA:17505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(long-chain fatty acyl)ethanolamine = a long-chain fatty acid + ethanolamine
RHEA:17505	skos:altLabel	"N-acylethanolamine amidohydrolase"
RHEA:17505	skos:prefLabel	"N-(long-chain-acyl)ethanolamine deacylase"
RHEA:17505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-(long-chain-acyl)ethanolamine deacylase"
RHEA:50112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + taurine = CoA + H(+) + N-octadecanoyl-taurine
REACT:R-RNO-209063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Rattus norvegicus)
REACT:R-HSA-6807134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Homo sapiens)
RHEA:50447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 <=> prostaglandin G3
RHEA:46695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + H(+) <=> 4-hydroxybenzoyl-5'-AMP + diphosphate
REACT:R-RNO-5653766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
RHEA:50206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2
RHEA:12680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + Latia luciferin + 2 O2 <=> A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin-E synthase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGH-PGE isomerase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin endoperoxide E isomerase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Prostaglandin-H(2) E-isomerase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoperoxide isomerase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin endoperoxide E2 isomerase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin R-prostaglandin E isomerase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin H-E isomerase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-H2 E-isomerase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGE2 isomerase activity
GO:0050220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGE isomerase activity
REACT:R-BTA-8852337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds TP53 (Bos taurus)
RHEA:72898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine
RHEA:23137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary amine + S-adenosyl-L-methionine => a methylated primary amine + H(+) + S-adenosyl-L-homocysteine
GO:0008904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:hygromycin-B 7''-O-phosphotransferase activity
GO:0008904	skos:prefLabel	"hygromycin-B 7''-O-kinase"
GO:0008904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APH(7'') activity
GO:0008904	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hygromycin-B kinase activity
GO:0008904	skos:altLabel	"hygromycin B phosphotransferase"
GO:0008904	skos:altLabel	"hygromycin-B kinase"
GO:0008904	skos:altLabel	"APH(7'')"
GO:0008904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hygromycin-B 7''-O-kinase"
GO:0008904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hygromycin-B 7''-O-phosphotransferase activity
GO:0008904	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hygromycin B phosphotransferase activity
GO:0008904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	destomic acid ring 7''-O-phosphotransferase activity
GO:0008904	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hygromycin B kinase activity
GO:0008904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + H(+)
RHEA:68008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate
REACT:R-MMU-2028679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Mus musculus)
REACT:R-CEL-164423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PhosphoChREBP (Thr 666)  is exported to cytosol (Caenorhabditis elegans)
RHEA:65054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trifluoromethyl)benzaldehyde + H(+) + NADH => 4-(trifluoromethyl)benzyl alcohol + NAD(+)
REACT:R-SCE-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Saccharomyces cerevisiae)
REACT:R-GGA-2404134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4:atROL binds TTR (Gallus gallus)
RHEA:22575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N-methyl-L-glutamate <=> AH2 + formaldehyde + L-glutamate
REACT:R-HSA-1220614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous dimerization of ligand-responsive EGFR mutants (Homo sapiens)
REACT:R-BTA-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Bos taurus)
REACT:R-MMU-2514790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by MMP14 (Mus musculus)
RHEA:43781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0140793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2-Y142 phosphatase activity
GO:0140793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone tyrosine phosphatase activity (H2-Y142 specific)
GO:0140793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2Y142 phosphatase activity
REACT:R-RNO-2028679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Rattus norvegicus)
RHEA:14473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"very-long-chain enoyl-CoA reductase"
RHEA:14473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH
RHEA:14473	skos:prefLabel	"very-long-chain enoyl-CoA reductase"
GO:0003846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl coenzyme A-monoglyceride acyltransferase activity
GO:0003846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoacylglycerol acyltransferase activity
GO:0003846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:2-acylglycerol O-acyltransferase activity
GO:0003846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylglycerol palmitoyltransferase activity
GO:0003846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acylglycerol O-acyltransferase activity
GO:0003846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoglyceride acyltransferase activity
REACT:R-DRE-6804468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO2 (Danio rerio)
REACT:R-CFA-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Canis familiaris)
REACT:R-HSA-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Homo sapiens)
REACT:R-DME-350395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol (Drosophila melanogaster)
RHEA:31598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylureidoacrylate + H2O <=> (Z)-2-methylaminoacrylate + carbamate + H(+)
RHEA:15537	skos:prefLabel	"(2R)-3-sulfolactate dehydrogenase (NADP(+))"
RHEA:15537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2R)-3-sulfolactate dehydrogenase (NADP(+))"
RHEA:15537	skos:altLabel	"(R)-sulfolactate dehydrogenase"
RHEA:15537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate + NADP(+) = 3-sulfopyruvate + H(+) + NADPH
RHEA:29150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + nitrate + ubiquinol-8 <=> 2 H(+)(out) + H2O + nitrite + ubiquinone-8
REACT:R-BTA-191999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Bos taurus)
REACT:R-DRE-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Danio rerio)
RHEA:18589	skos:altLabel	"[glutamate--ammonia-ligase] adenylyltransferase"
RHEA:18589	skos:prefLabel	"[glutamine synthetase] adenylyltransferase"
RHEA:18589	skos:altLabel	"glutamine-synthetase adenylyltransferase"
RHEA:18589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate
RHEA:18589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[glutamine synthetase] adenylyltransferase"
RHEA:18589	skos:altLabel	"glutamate-ammonia-ligase adenylyltransferase"
REACT:R-BTA-446692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 binds to MYD88 within the IL1R complex (Bos taurus)
REACT:R-BTA-9755306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub UBXN7 is degraded by the 26S proteasome (Bos taurus)
REACT:R-MMU-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Mus musculus)
RHEA:42136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine
REACT:R-DME-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Drosophila melanogaster)
REACT:R-DME-1855225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Drosophila melanogaster)
RHEA:65567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine
REACT:R-SPO-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Schizosaccharomyces pombe)
RHEA:58486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + sphing-4-enine => H2O + N-(acetyl)-sphing-4-enine
REACT:R-HSA-6798282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 and E2F4 bind the CDC25C gene (Homo sapiens)
REACT:R-XTR-3769391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 binds the beta-catenin:CBY complex (Xenopus tropicalis)
REACT:R-CFA-389350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 by pVav1 (Canis familiaris)
REACT:R-SSC-8948018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Sus scrofa)
REACT:R-SSC-6786034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Sus scrofa)
GO:0050615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydrovomilenine reductase activity
GO:0050615	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17-O-acetylnorajmaline:NADP+ oxidoreductase activity
REACT:R-RNO-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Rattus norvegicus)
RHEA:57390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]
GO:0045482	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sesquiterpene cyclase activity
GO:0045482	skos:prefLabel	"trichodiene synthase"
GO:0045482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity
GO:0045482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trichodiene synthase activity
GO:0045482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)
GO:0045482	skos:altLabel	"trichodiene synthetase"
GO:0045482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trichodiene synthetase activity
GO:0045482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trichodiene synthase"
GO:0045482	skos:altLabel	"sesquiterpene cyclase"
GO:0045482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + trichodiene
REACT:R-MMU-210300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and TREM2 (Mus musculus)
REACT:R-HSA-2430552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D (Homo sapiens)
REACT:R-BTA-5688294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT5 deacetylates Cytochrome C (Bos taurus)
RHEA:53578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-5610766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Sus scrofa)
RHEA:28058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lyxopyranose = L-xylulose
REACT:R-RNO-201677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Rattus norvegicus)
REACT:R-XTR-196126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from cytosol to mitochondrial intermembrane space (Xenopus tropicalis)
RHEA:62353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide D
REACT:R-HSA-8987156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Homo sapiens)
RHEA:46902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)
RHEA:23810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine
REACT:R-DRE-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Danio rerio)
RHEA:28926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-phenylalanine(in) <=> H(+)(out) + L-phenylalanine(out)
RHEA:43225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-GGA-380942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LKB1 forms a trimeric complex with STRAD and MO25 (Gallus gallus)
GO:0031546	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	brain-derived neurotrophic factor ligand
GO:0031546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brain-derived neurotrophic factor receptor binding
GO:0031546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDNF receptor binding
REACT:R-SSC-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Sus scrofa)
REACT:R-DRE-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Danio rerio)
GO:0050081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose-6'-phosphate glucosidase activity
GO:0050081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-alpha-glucosidase activity
GO:0050081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltose-6'-phosphate 6-phosphoglucohydrolase activity
RHEA:58263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] <=> ADP-D-ribose + L-tyrosyl-[protein]
REACT:R-GGA-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Gallus gallus)
RHEA:15975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+) => 3'-phosphoadenylyl sulfate + estrone
REACT:R-CEL-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Caenorhabditis elegans)
RHEA:63045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mevastatin => H(+) + mevinic carboxylate
REACT:R-GGA-9630923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B inhibitor binds NF-kappa-B complex (Gallus gallus)
REACT:R-HSA-5669012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA binds EDAR (Homo sapiens)
RHEA:20525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + ethylamine + L-glutamate = ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate
RHEA:20525	skos:altLabel	"theanine synthetase"
RHEA:20525	skos:prefLabel	"glutamate--ethylamine ligase"
RHEA:20525	skos:altLabel	"N(5)-ethyl-L-glutamine synthetase"
RHEA:20525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate--ethylamine ligase"
REACT:R-RNO-2309779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer binds PTGS2 inhibitors (Rattus norvegicus)
REACT:R-SSC-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Sus scrofa)
RHEA:26382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + NADP(+) => H(+) + NADPH + succinate semialdehyde
REACT:R-DRE-8874201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L3 (Danio rerio)
RHEA:72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate => 2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)
REACT:R-DME-5610742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI1 (Drosophila melanogaster)
REACT:R-BTA-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Bos taurus)
REACT:R-DME-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Drosophila melanogaster)
REACT:R-CEL-1855180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)
REACT:R-RNO-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Rattus norvegicus)
REACT:R-XTR-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Xenopus tropicalis)
GO:1990055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetaldehyde synthase activity
GO:1990055	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aromatic aldehyde synthase
RHEA:54408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:32274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate + NAD(+) <=> 4-methyl-2-oxopentanoate + CO2 + NADH
REACT:R-MMU-5218836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2beta binds alphaVbeta3 (Mus musculus)
REACT:R-HSA-2130627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen internalization (Homo sapiens)
REACT:R-RNO-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Rattus norvegicus)
REACT:R-XTR-209738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 binds GC (Xenopus tropicalis)
REACT:R-DME-1236398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds NRGs or EGF-like ligands (Drosophila melanogaster)
REACT:R-MMU-2730889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)
RHEA:36909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA
REACT:R-SCE-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Saccharomyces cerevisiae)
REACT:R-BTA-170070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)
RHEA:23476	skos:altLabel	"indoleglycerol phosphate synthetase"
RHEA:23476	skos:prefLabel	"indole-3-glycerol-phosphate synthase"
RHEA:23476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
RHEA:23476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-glycerol-phosphate synthase"
RHEA:20327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetoxy-4-aminobiphenyl => N-hydroxy-4-acetylaminobiphenyl
GO:0034790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity
REACT:R-DRE-5620914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF4:GTP binds VxPx-motifs of membrane proteins (Danio rerio)
REACT:R-RNO-6784861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG binds LPL dimer (Rattus norvegicus)
REACT:R-HSA-9029531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ABCG5 regulated by NR1H2,3 (Homo sapiens)
GO:0035380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0035380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0004502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-kynurenine-3-hydroxylase activity
GO:0004502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
GO:0004502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine 3-hydroxylase activity
GO:0004502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine 3-monooxygenase activity
GO:0004502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenine hydroxylase activity
REACT:R-SCE-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Saccharomyces cerevisiae)
GO:0102181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity
REACT:R-RNO-6797913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARDH:FAD oxidatively demethylates SARC to Gly (Rattus norvegicus)
REACT:R-HSA-2974737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 binds MDK (Homo sapiens)
RHEA:43560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate
REACT:R-RNO-8866542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Rattus norvegicus)
REACT:R-BTA-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Bos taurus)
REACT:R-XTR-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Xenopus tropicalis)
REACT:R-MMU-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Mus musculus)
RHEA:41244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine
RHEA:60649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphoethanolamine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine
GO:0102685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity
RHEA:17446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-SCE-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
REACT:R-RNO-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Rattus norvegicus)
RHEA:58743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + psi-UTP <=> diphosphate + H(+) + psi-UMP
REACT:R-DRE-3249378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING recruits TBK1 and STAT6 (Danio rerio)
RHEA:69245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate => 5-methylsulfinylpentyl nitrile + sulfate + sulfur
GO:0047700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	b-glucoside kinase activity
GO:0047700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucoside kinase activity
GO:0047700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-glucoside kinase (phosphorylating)
GO:0047700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:cellobiose 6-phosphotransferase activity
REACT:R-MMU-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Mus musculus)
RHEA:62519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP
REACT:R-HSA-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Homo sapiens)
REACT:R-GGA-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Gallus gallus)
RHEA:12517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-(R)-germacrene A + diphosphate
GO:0120013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intermembrane lipid transfer activity
GO:0120013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid transfer activity
GO:0120013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid carrier activity
RHEA:45966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AMP + ATP + 2 H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O
REACT:R-SSC-2161917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15S-HpETE to LXA4/B4 (Sus scrofa)
GO:0016758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hexosyltransferases"
GO:0016758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexosyltransferase activity
GO:0016758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring hexosyl groups
GO:0016758	skos:prefLabel	"Hexosyltransferases"
REACT:R-MMU-5685604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF6 binds SLAMF6 (Mus musculus)
RHEA:52201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aci-nitro-2-(phenyl)ethane + glutathione => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O
REACT:R-HSA-5663105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds BHLHE41 (DEC2) gene (Homo sapiens)
RHEA:39390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O
RHEA:25780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetyl-D-mannosamine dehydrogenase"
RHEA:25780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate
RHEA:25780	skos:altLabel	"UDP-ManNAc 6-dehydrogenase"
RHEA:25780	skos:prefLabel	"UDP-N-acetyl-D-mannosamine dehydrogenase"
GO:0047102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxymuconic acid semialdehyde dehydrogenase activity
GO:0047102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxymuconate semialdehyde dehydrogenase activity
GO:0047102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity
GO:0047102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxymuconic semialdehyde dehydrogenase activity
GO:0047102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity
GO:0047102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity
GO:0047102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminomuconate-semialdehyde dehydrogenase activity
GO:0047102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminomuconate semialdehyde dehydrogenase activity
RHEA:65456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-1-ol + acetyl-CoA = 2-methylbutyl acetate + CoA
REACT:R-CFA-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Canis familiaris)
REACT:R-MMU-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Mus musculus)
RHEA:36838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:23190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanal + H(+) + NADH => NAD(+) + propane-1,3-diol
RHEA:65542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => ganglioside GM3 + H2O
GO:0097372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone H3-K18 deacetylase activity
GO:0097372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone H3K18 deacetylase activity
GO:0097372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone deacetylase activity (H3-K18 specific)
RHEA:33188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
GO:0090710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphomevalonate decarboxylase activity
REACT:R-SCE-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Saccharomyces cerevisiae)
RHEA:23164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose = a flavonol 7-O-beta-D-glucoside + H(+) + UDP
RHEA:23164	skos:altLabel	"UDP-glucose:flavonol 7-O-glucosyltransferase"
RHEA:23164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonol 7-O-beta-glucosyltransferase"
RHEA:23164	skos:prefLabel	"flavonol 7-O-beta-glucosyltransferase"
RHEA:54281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate
RHEA:25020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate
RHEA:71921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(in) + succinate(in) => 3 Na(+)(out) + succinate(out)
RHEA:48784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-erythrulose 4-phosphate isomerase"
RHEA:48784	skos:prefLabel	"D-erythrulose 4-phosphate isomerase"
RHEA:48784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose 4-phosphate = D-erythrose 4-phosphate
RHEA:72055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate(out) + 2 Na(+)(out) = glycodeoxycholate(in) + 2 Na(+)(in)
RHEA:12600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + phosphinothricin <=> CoA + H(+) + N-acetylphosphinothricin
GO:0060229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipase activator activity
RHEA:41027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA
RHEA:71285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-glutamine(in) + 2 Na(+)(in) => chloride(out) + L-glutamine(out) + 2 Na(+)(out)
REACT:R-SSC-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Sus scrofa)
RHEA:12765	skos:altLabel	"pyruvic-ferredoxin oxidoreductase"
RHEA:12765	skos:altLabel	"alpha-ketobutyrate-ferredoxin oxidoreductase"
RHEA:12765	skos:altLabel	"alpha-ketobutyrate synthase"
RHEA:12765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:12765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate synthase"
RHEA:12765	skos:altLabel	"pyruvate synthetase"
RHEA:12765	skos:prefLabel	"pyruvate synthase"
RHEA:12765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:12765	skos:altLabel	"2-oxobutyrate synthase"
RHEA:12765	skos:altLabel	"2-oxobutyrate-ferredoxin oxidoreductase"
RHEA:12765	skos:altLabel	"pyruvate oxidoreductase"
REACT:R-DRE-2162227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses (HA)2 (Danio rerio)
REACT:R-DRE-176879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein(a) + LDL => Lp(a) (Danio rerio)
REACT:R-CFA-1497869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)
REACT:R-HSA-383363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 2 (NK2) binds to nuerokinin A (Homo sapiens)
REACT:R-HSA-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Homo sapiens)
REACT:R-HSA-1112755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds IL6ST (Homo sapiens)
RHEA:66363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O <=> (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)
REACT:R-MMU-6786166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translesion synthesis across unhooked ICL by POLN (Mus musculus)
RHEA:69990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) <=> (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH
REACT:R-DDI-4085994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates SIN3A with SUMO1 (Dictyostelium discoideum)
REACT:R-DDI-1497869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - Sepiapterin is reduced to BH2 (Dictyostelium discoideum)
REACT:R-HSA-157145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds DLL1 (Homo sapiens)
REACT:R-SSC-1971483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Sus scrofa)
RHEA:13483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-methionyl-tRNA(Met) => ATP + L-methionine + tRNA(Met)
RHEA:27973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotriose + H2O <=> alpha-D-glucose + D-maltose
REACT:R-SCE-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Saccharomyces cerevisiae)
REACT:R-CFA-5661117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Canis familiaris)
REACT:R-BTA-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Bos taurus)
RHEA:58891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + AH2 + 2 O2 <=> 4-nitrobenzoate + A + 2 H2O
REACT:R-DME-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Drosophila melanogaster)
REACT:R-CEL-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)
REACT:R-CFA-69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Canis familiaris)
REACT:R-MMU-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Mus musculus)
REACT:R-MMU-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)
REACT:R-XTR-419843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCR (Xenopus tropicalis)
RHEA:32336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-endo-fenchol + NADP(+) => (1S,4R)-fenchone + H(+) + NADPH
RHEA:71170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(out) + H(+)(in) + Na(+)(out) <=> glycine(in) + H(+)(out) + Na(+)(in)
RHEA:19416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
GO:0098613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeH is methylated to Me2Se by MeSeH methyltransferase (Homo sapiens)
GO:0098613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methaneselenol methyltransferase activity
RHEA:52037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate => L-isoleucine + tuberonate
REACT:R-MMU-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Mus musculus)
REACT:R-CFA-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Canis familiaris)
RHEA:30436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)
REACT:R-DRE-8981093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12 bound to IL12R internalises (Danio rerio)
RHEA:52139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)
REACT:R-MMU-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Mus musculus)
RHEA:63227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol
RHEA:51648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2
REACT:R-CFA-2025723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the N-glycan precursor (Canis familiaris)
RHEA:20610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-arabinonate => glycolaldehyde + pyruvate
REACT:R-DRE-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)
REACT:R-XTR-8964241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta-gamma complex and PIP3 recruit BTK to membrane (Xenopus tropicalis)
REACT:R-RNO-158357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIIa binds SERPING1 (Rattus norvegicus)
RHEA:31590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NADH + O2 + uracil <=> (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)
RHEA:25047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)
RHEA:18631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + NADP(+) => ATP + NAD(+)
REACT:R-HSA-186778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 binds to the active receptor (Homo sapiens)
REACT:R-HSA-9727303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA9 is translated to protein 9b (Homo sapiens)
RHEA:63402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(II)-heme a + H2O => Fe(II)-hydroxyheme i
REACT:R-HSA-6807106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN undergoes monoubiquitination (Homo sapiens)
REACT:R-CFA-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Canis familiaris)
RHEA:15098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formimidoyltetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate
REACT:R-GGA-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Gallus gallus)
RHEA:22128	skos:prefLabel	"(-)-borneol dehydrogenase"
RHEA:22128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R,4S)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH
RHEA:22128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-borneol dehydrogenase"
RHEA:49594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA => 2-hydroxyisobutanoyl-CoA
GO:0051907	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-(hydroxymethyl)glutathione formaldehyde-lyase activity
GO:0051907	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Gfa
GO:0051907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(hydroxymethyl)glutathione synthase activity
GO:0051907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-dependent formaldehyde-activating enzyme activity
GO:0051907	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)
REACT:R-BTA-114558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate Gq (Bos taurus)
REACT:R-SSC-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)
REACT:R-DRE-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Danio rerio)
RHEA:19528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (1S,8aR)-delta-cadinene + diphosphate
RHEA:17125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine = 2-oxoglutarate + N-(2-aminobutanoyl)glycine
REACT:R-SSC-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Sus scrofa)
REACT:R-CFA-5654640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
REACT:R-MMU-5662606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds zinc (Mus musculus)
RHEA:45693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(octanoyl)-sphing-4-enine-1-phosphate(in) => N-(octanoyl)-sphing-4-enine-1-phosphate(out)
REACT:R-BTA-508163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Bos taurus)
RHEA:27810	skos:prefLabel	"(2Z,6Z)-farnesyl diphosphate synthase"
RHEA:27810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2Z,6Z)-farnesyl diphosphate synthase"
RHEA:27810	skos:altLabel	"zFPS"
RHEA:27810	skos:altLabel	"cis,cis-farnesyl diphosphate synthase"
RHEA:27810	skos:altLabel	"Z,Z-FPP synthase"
RHEA:27810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + 2 isopentenyl diphosphate = (2Z,6Z)-farnesyl diphosphate + 2 diphosphate
RHEA:27810	skos:altLabel	"Z,Z-farnesyl pyrophosphate synthase"
REACT:R-HSA-444838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 1 binds relaxin 2 and 3 (Homo sapiens)
REACT:R-CEL-5624127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome target cargo to the primary cilium (Caenorhabditis elegans)
REACT:R-SSC-9701531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727 STAT3 is acetylated (Sus scrofa)
RHEA:22085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate
REACT:R-CFA-201521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK autophosphorylation downstream of PTN and MDK (Canis familiaris)
EC:3.2.1.154	skos:altLabel	"beta-(2-6)-fructan exohydrolase"
EC:3.2.1.154	skos:altLabel	"levanase"
EC:3.2.1.154	skos:altLabel	"6-FEH"
EC:3.2.1.154	skos:prefLabel	"fructan beta-(2,6)-fructosidase"
EC:3.2.1.154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructan beta-(2,6)-fructosidase"
REACT:R-RNO-1028820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of VAF (virus-activated factor) complex (Rattus norvegicus)
RHEA:18215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + CTP + H(+)
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta(3)-delta(2)-enoyl-CoA isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta3-cis-delta2-trans-enoyl-CoA isomerase
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dodecenoyl-CoA isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta3,delta2-enoyl-CoA isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta3-delta2 enoyl-CoA isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylene-allene isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dodecenoyl-CoA delta-isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dodecenoyl-CoA D-isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dodecenoyl-CoA (3Z)-(2E)-isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(3),delta(2)-enoyl-CoA isomerase activity
GO:0004165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,2-trans-enoyl-CoA isomerase activity
RHEA:15986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + NAD(+) => CO2 + NADH
REACT:R-DDI-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Dictyostelium discoideum)
RHEA:51250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2
REACT:R-SPO-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Schizosaccharomyces pombe)
REACT:R-CEL-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Caenorhabditis elegans)
RHEA:28078	skos:prefLabel	"phosphonoacetaldehyde reductase (NADH)"
RHEA:28078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + NAD(+) = H(+) + NADH + phosphonoacetaldehyde
RHEA:28078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphonoacetaldehyde reductase (NADH)"
EC:3.6.5.4	skos:prefLabel	"signal-recognition-particle GTPase"
EC:3.6.5.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"signal-recognition-particle GTPase"
RHEA:65797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-GGA-433786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 (Gallus gallus)
REACT:R-GGA-8852266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Gallus gallus)
REACT:R-HSA-9024161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) (Homo sapiens)
REACT:R-DRE-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Danio rerio)
RHEA:68871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + benzoate + H(+) + NADPH <=> AMP + benzaldehyde + diphosphate + NADP(+)
RHEA:52229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O
REACT:R-HSA-1793209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses Chondroitin chains (Homo sapiens)
REACT:R-CFA-6807206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)
RHEA:10624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + CO2 + H2O + NH4(+) = 2 ADP + carbamoyl phosphate + 3 H(+) + phosphate
RHEA:71604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + oxaloacetate(in) => 2-oxoglutarate(in) + oxaloacetate(out)
RHEA:20901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-benzyloxycarbonylglycine => benzyl alcohol + CO2 + glycine
REACT:R-CFA-3222072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAXX binds Ub-MDM2 and USP7 (Canis familiaris)
REACT:R-CFA-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)
REACT:R-HSA-3782535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Homo sapiens)
REACT:R-MMU-2534248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP2, MMP3, MMP7 (Mus musculus)
RHEA:18361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl D-xylosyl phosphate + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)
RHEA:18361	skos:prefLabel	"dolichyl-xylosyl-phosphate--protein xylosyltransferase"
RHEA:18361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-xylosyl-phosphate--protein xylosyltransferase"
RHEA:26221	skos:altLabel	"CYP720B1"
RHEA:26221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"abieta-7,13-dien-18-ol hydroxylase"
RHEA:26221	skos:altLabel	"abietadienol hydroxylase"
RHEA:26221	skos:prefLabel	"abieta-7,13-dien-18-ol hydroxylase"
RHEA:26221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1605591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Rattus norvegicus)
REACT:R-CFA-888614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO2 dioxygenates L-Trp to NFK (Canis familiaris)
RHEA:37533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine
REACT:R-DME-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Drosophila melanogaster)
REACT:R-GGA-1227867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK binds polyubiquitinated TRAF3/6 (Gallus gallus)
REACT:R-RNO-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Rattus norvegicus)
REACT:R-GGA-5662608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds cadmium (Gallus gallus)
REACT:R-DME-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Drosophila melanogaster)
RHEA:56401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)
RHEA:67781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
RHEA:56985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (6E)-nerolidol + diphosphate
REACT:R-SPO-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Schizosaccharomyces pombe)
REACT:R-MMU-109415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => adenosine + orthophosphate [NT5C1B] (Mus musculus)
RHEA:57320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] = CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]
REACT:R-DRE-9718379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds chemical antagonists (Danio rerio)
REACT:R-DME-390059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPO dimer binds to RASSF (Drosophila melanogaster)
REACT:R-HSA-9033240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5L binds PEX7:Cargo protein (Homo sapiens)
GO:0036054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein lysine demalonylation activity
GO:0036054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein malonyl lysine demalonylation activity
GO:0036054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-malonyllysine demalonylase activity
GO:0036054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-malonyllysine demalonylase activity
RHEA:23400	skos:altLabel	"7,8-dihydroxykynurenate oxygenase"
RHEA:23400	skos:prefLabel	"7,8-dihydroxykynurenate 8,8a-dioxygenase"
RHEA:23400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)
RHEA:23400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7,8-dihydroxykynurenate 8,8a-dioxygenase"
RHEA:28759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)
RHEA:28759	skos:prefLabel	"TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase"
RHEA:28759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase"
RHEA:20950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + sulfoacetaldehyde => 3-sulfopyruvate + H(+)
REACT:R-RNO-351936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of claspin (Rattus norvegicus)
RHEA:58862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:59440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl alcohol + H(+) + NADPH = (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)
REACT:R-MMU-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Mus musculus)
REACT:R-HSA-374680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 trans-homophilic interaction (Homo sapiens)
REACT:R-CFA-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Canis familiaris)
GO:0015603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron chelate transmembrane transporter activity
REACT:R-GGA-190427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1b (Gallus gallus)
REACT:R-SSC-69140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap (Sus scrofa)
REACT:R-DDI-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Dictyostelium discoideum)
EC:3.4.21.-	skos:prefLabel	"Serine endopeptidases"
EC:3.4.21.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Serine endopeptidases"
RHEA:13703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-acetyl-L-homoserine => acetyl-CoA + L-homoserine
RHEA:28559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + H2O => D-fructose + phosphate
REACT:R-MMU-3149563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Mus musculus)
REACT:R-RNO-5340251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Rattus norvegicus)
REACT:R-HSA-9660822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds P2RX4,7 (Homo sapiens)
REACT:R-CEL-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Caenorhabditis elegans)
RHEA:61729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-dehydro-D-guloside => a 3-dehydro-D-glucoside
RHEA:28147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] => 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-3000120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLIF binds RCbl (Homo sapiens)
REACT:R-HSA-2161890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Homo sapiens)
RHEA:11152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-pyridoxate monooxygenase"
RHEA:11152	skos:altLabel	"5-pyridoxate oxidase"
RHEA:11152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)
RHEA:11152	skos:prefLabel	"5-pyridoxate monooxygenase"
RHEA:11152	skos:altLabel	"5-pyridoxate dioxygenase"
REACT:R-HSA-9624800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LBR (Homo sapiens)
REACT:R-DDI-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)
REACT:R-HSA-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Homo sapiens)
RHEA:56318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acetylamino-4-hydroxybenzoate + CoA => 3-amino-4-hydroxybenzoate + acetyl-CoA
REACT:R-HSA-8961846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNE1 gene transcription is stimulated by E2F1 (Homo sapiens)
RHEA:64688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP
RHEA:63199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10bR,4aS)-noroxomaritidine + H(+) + NADPH <=> (10bR,4aS)-oxomaritidine + NADP(+)
REACT:R-CFA-75126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Canis familiaris)
RHEA:13137	skos:altLabel	"sterol C-methyltransferase"
RHEA:13137	skos:prefLabel	"cycloartenol 24-C-methyltransferase"
RHEA:13137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cycloartenol 24-C-methyltransferase"
RHEA:13137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloartenol + S-adenosyl-L-methionine = cyclolaudenol + H(+) + S-adenosyl-L-homocysteine
RHEA:70602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-GGA-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Gallus gallus)
REACT:R-CFA-3134953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 or DHX9 binds MyD88 (Canis familiaris)
REACT:R-XTR-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Xenopus tropicalis)
RHEA:11981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 gamma-L-glutamyl-L-cysteine + NADP(+) => bis-gamma-glutamylcystine + H(+) + NADPH
GO:0102341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-lignoceroyl-CoA reductase activity
GO:0047537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	norleucine transaminase activity
GO:0047537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	norleucine aminotransferase activity
GO:0047537	skos:altLabel	"2-aminohexanoate aminotransferase"
GO:0047537	skos:prefLabel	"2-aminohexanoate transaminase"
GO:0047537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-2-aminohexanoate = 2-oxohexanoate + L-glutamate
GO:0047537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminohexanoate transaminase activity
GO:0047537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-aminohexanoate:2-oxoglutarate aminotransferase activity
GO:0047537	skos:altLabel	"norleucine aminotransferase"
GO:0047537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	norleucine (leucine) aminotransferase activity
GO:0047537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine L-norleucine: 2-oxoglutarate aminotransferase activity
GO:0047537	skos:altLabel	"norleucine transaminase"
GO:0047537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-aminohexanoate transaminase"
GO:0047537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminohexanoate aminotransferase activity
RHEA:14985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
RHEA:14985	skos:prefLabel	"arachidonate 8-lipoxygenase"
RHEA:14985	skos:altLabel	"8-lipoxygenase"
RHEA:14985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arachidonate 8-lipoxygenase"
REACT:R-DRE-9014467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the ER membrane (Danio rerio)
REACT:R-XTR-8986995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Xenopus tropicalis)
REACT:R-CFA-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Canis familiaris)
REACT:R-CFA-2404135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4 binds atROL (Canis familiaris)
REACT:R-DDI-9714480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the mitochondrial membrane (Dictyostelium discoideum)
REACT:R-CFA-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Canis familiaris)
REACT:R-RNO-6804741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 forms homo- or heterodimers (Rattus norvegicus)
RHEA:19389	skos:altLabel	"trans-feruloyl-CoA synthetase"
RHEA:19389	skos:prefLabel	"trans-feruloyl-CoA synthase"
RHEA:19389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + AMP + diphosphate
RHEA:19389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-feruloyl-CoA synthase"
RHEA:19389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + ADP + phosphate
RHEA:15883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein] => ATP + L-seryl-[Fas-activated protein]
RHEA:16508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate <=> 4-hydroxybenzoate + pyruvate
RHEA:57165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 => (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate
RHEA:56973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-2-methylpropanoate + NAD(+) => (R)-methylmalonate semialdehyde + H(+) + NADH
REACT:R-CFA-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Canis familiaris)
REACT:R-HSA-8949687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)
REACT:R-DRE-2046298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to a branch of keratan (Danio rerio)
REACT:R-SSC-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Sus scrofa)
REACT:R-GGA-109539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Gallus gallus)
REACT:R-CFA-975916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 5 by MGAT5 (Canis familiaris)
GO:0102513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity
REACT:R-BTA-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Bos taurus)
RHEA:32204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-synephrine => (4-hydroxyphenyl)acetaldehyde + methylamine
RHEA:66755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O <=> (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate
GO:0019769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	low affinity Fc receptor activity
GO:0019769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity IgE receptor activity
GO:0019769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity IgE receptor activity
REACT:R-HSA-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-HSA-170799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)
RHEA:31658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine
REACT:R-SSC-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Sus scrofa)
REACT:R-XTR-936564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 inhibits MAVS-DDX58 interaction. (Xenopus tropicalis)
REACT:R-CEL-168440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Caenorhabditis elegans)
REACT:R-DME-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Drosophila melanogaster)
REACT:R-MMU-9614271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ADGRG6 (Mus musculus)
RHEA:68440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin + O2 = (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal
RHEA:29409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2
RHEA:37482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-RNO-8878914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Rattus norvegicus)
RHEA:61404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(D-ribulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine
REACT:R-HSA-9011241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates ROBO3.1 in response to NTN1 (Homo sapiens)
GO:0016622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a cytochrome as acceptor"
GO:0016622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor
GO:0016622	skos:prefLabel	"With a cytochrome as acceptor"
REACT:R-RNO-193385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of choloyl-CoA to cholate and CoASH (Rattus norvegicus)
REACT:R-HSA-3769370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIF1 binds WNTs (Homo sapiens)
RHEA:71760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + heptanedioate(in) => 2-oxoglutarate(in) + heptanedioate(out)
REACT:R-XTR-2022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to heparan (Xenopus tropicalis)
REACT:R-HSA-8963851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 dissociates from GC (Homo sapiens)
RHEA:13215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + succinate => H2O + NADP(+) + succinate semialdehyde
GO:0051916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte colony stimulating factor binding
GO:0051916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-CSF binding
GO:0051916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte colony-stimulating factor binding
REACT:R-BTA-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Bos taurus)
REACT:R-CFA-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Canis familiaris)
REACT:R-DRE-5669250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates FLNA (Danio rerio)
RHEA:43243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate
RHEA:37380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-CFA-5693602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM recognizes H2AFX-Nucleosomes (Canis familiaris)
REACT:R-CEL-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Caenorhabditis elegans)
REACT:R-HSA-8983059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Homo sapiens)
RHEA:11399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyldeoxycytidine 5'-phosphate + ATP <=> 5-methyldeoxycytidine diphosphate + ADP
RHEA:11383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 <=> [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate
REACT:R-DDI-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Dictyostelium discoideum)
REACT:R-RNO-9647632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDME (Rattus norvegicus)
GO:0047657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-alpha-glucan synthase activity
GO:0047657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-1,3-glucan synthase activity
GO:0047657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity
GO:0047657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity
GO:0047657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3-glucan synthase activity
GO:0047657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-alpha-D-glucan synthase activity
GO:0047657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP
GO:0047657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-1,3-glucan synthase"
GO:0047657	skos:prefLabel	"alpha-1,3-glucan synthase"
GO:0047657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity
REACT:R-DRE-2161768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXA4 is converted to EXC4 by LTC4S (Danio rerio)
REACT:R-CFA-6788385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of ATR and ATRIP is recruited to ICL-DNA (Canis familiaris)
REACT:R-SSC-418442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Sus scrofa)
RHEA:50415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] <=> H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)
RHEA:71794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate(in) + H(+)(in) <=> (R)-lactate(out) + H(+)(out)
REACT:R-HSA-9665280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 KD mutants do not bind osimertinib (Homo sapiens)
REACT:R-MMU-420591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-2:Nectin 3 trans heterodimer interaction (Mus musculus)
RHEA:60275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-MMU-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)
REACT:R-HSA-1482695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Homo sapiens)
REACT:R-XTR-8876837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB21 GEFs exchange GTP for GDP on RAB21 (Xenopus tropicalis)
REACT:R-SSC-5626981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Sus scrofa)
RHEA:50152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O
REACT:R-RNO-9033533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)
REACT:R-HSA-3240777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1/2/3:DP1/2 binds EZH2 gene promoter (Homo sapiens)
REACT:R-CFA-9629195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Canis familiaris)
REACT:R-XTR-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Xenopus tropicalis)
REACT:R-DRE-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Danio rerio)
RHEA:48314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2
REACT:R-RNO-418176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB2 binds MAPKs, SRC-1 (Rattus norvegicus)
REACT:R-DME-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Drosophila melanogaster)
RHEA:14232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:43178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine
REACT:R-HSA-377186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
EC:3.5.4.7	skos:prefLabel	"ADP deaminase"
EC:3.5.4.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP deaminase"
REACT:R-DME-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Drosophila melanogaster)
REACT:R-XTR-6787757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates acidic AAs (Xenopus tropicalis)
RHEA:43713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dodecanoate + H(+) => diphosphate + dodecanoyl-AMP
REACT:R-XTR-8940070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NAD+ (Xenopus tropicalis)
REACT:R-DRE-2288097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Condensin II complex binds H4K20me1-containing nucleosomes (Danio rerio)
REACT:R-DRE-9726949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIR binds PTGIR agonists (Danio rerio)
REACT:R-HSA-446862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)
RHEA:29805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-valine(in) + phosphate => ATP + H2O + L-valine(out)
REACT:R-XTR-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Xenopus tropicalis)
REACT:R-MMU-5655193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIAA0101 double monoubiquitination (Mus musculus)
REACT:R-DDI-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-DRE-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Danio rerio)
REACT:R-RNO-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)
RHEA:12836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-glutamate + H2O <=> a carboxylate + D-glutamate
REACT:R-CFA-3341296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX7,8 catalyze peroxidation of P4HB (PDI) (Canis familiaris)
RHEA:44118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + eicosanyl hexadecanoate => eicosan-1-ol + hexadecanoyl-CoA
RHEA:14887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + L-arginyl-[protein] => H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein]
REACT:R-DME-8871260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD2 (Drosophila melanogaster)
RHEA:51624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + GTP + H(+) = CO2 + dGTP + H2O
RHEA:63306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O
REACT:R-RNO-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Rattus norvegicus)
REACT:R-RNO-74726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of insulin from insulin receptor (Rattus norvegicus)
REACT:R-RNO-8874082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates PTK2 (Rattus norvegicus)
RHEA:29040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-aspartate(out) => ADP + H(+) + L-aspartate(in) + phosphate
REACT:R-HSA-1483116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCho is hydrolyzed to Cho and G3P by GPCPD1 (Homo sapiens)
REACT:R-CFA-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Canis familiaris)
REACT:R-CEL-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Caenorhabditis elegans)
REACT:R-MMU-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Mus musculus)
REACT:R-SSC-8987236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Sus scrofa)
REACT:R-DRE-141423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the MCC complex to the APC/C complex (Danio rerio)
REACT:R-XTR-3000335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Xenopus tropicalis)
RHEA:47775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:55984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile + UDP-alpha-D-glucose = (R)-prunasin + H(+) + UDP
RHEA:55984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-mandelonitrile beta-glucosyltransferase"
RHEA:55984	skos:prefLabel	"(R)-mandelonitrile beta-glucosyltransferase"
RHEA:55984	skos:altLabel	"UGT85A19"
RHEA:46687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-24-oyl-CoA + A <=> (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2
REACT:R-CFA-8879117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT2 transfers GlcNAc to Man-DAG1 (Canis familiaris)
RHEA:72034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + O2 <=> (E)-sinapaldehyde + H2O2
RHEA:61133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + kaempferol + succinate
RHEA:52970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate
REACT:R-HSA-9628737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 G83D does not cleave DHU (Homo sapiens)
GO:0018782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-chloroacrylic acid dehalogenase activity
RHEA:64536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base
RHEA:64536	skos:prefLabel	"inositol phosphorylceramide synthase"
RHEA:64536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol phosphorylceramide synthase"
REACT:R-MMU-5229194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Depolymerization of lamin filaments after PKC-mediated phosphorylation (Mus musculus)
RHEA:25001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-phenylalanine => (E)-phenylacetaldehyde oxime + CO2 + H2O
REACT:R-MMU-947535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Mus musculus)
REACT:R-MMU-5694436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 and MIA3 dissociate from procollagen VII vesicle (Mus musculus)
REACT:R-CFA-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)
REACT:R-DRE-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Danio rerio)
REACT:R-SSC-9603302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (peptide) binds IIa (Sus scrofa)
RHEA:64248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + glycine = CoA + H(+) + N-decanoylglycine
REACT:R-HSA-114352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of tBID by BCL-2 (Homo sapiens)
REACT:R-MMU-193965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 18HCORST to ALDO (Mus musculus)
REACT:R-HSA-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Homo sapiens)
REACT:R-CEL-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Caenorhabditis elegans)
REACT:R-SSC-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Sus scrofa)
EC:4.2.1.101	skos:prefLabel	"trans-feruloyl-CoA hydratase"
EC:4.2.1.101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-feruloyl-CoA hydratase"
EC:4.2.1.101	skos:altLabel	"4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)"
GO:0140906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	halogenase activity
RHEA:23877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoaphin aglucone => H2O + xanthoaphin
RHEA:72010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate(in) + urate(out) <=> succinate(out) + urate(in)
REACT:R-SSC-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Sus scrofa)
RHEA:18136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + diphosphate
RHEA:59975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + L-seryl-[protein] <=> CoA + O-decanoyl-L-seryl-[protein]
REACT:R-CFA-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Canis familiaris)
REACT:R-DRE-6810464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT14 hydrolyses UDP-Glc to G1P and UMP (Danio rerio)
RHEA:58975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + vanillin <=> H(+) + H2O2 + vanillate
REACT:R-RNO-5690042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)
REACT:R-SSC-109480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Sus scrofa)
REACT:R-XTR-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Xenopus tropicalis)
REACT:R-CFA-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Canis familiaris)
REACT:R-HSA-400046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-type Calcium Channels close in pancreatic beta cells (Homo sapiens)
RHEA:12200	skos:prefLabel	"2'-deoxymugineic-acid 2'-dioxygenase"
RHEA:12200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + mugineate + succinate
RHEA:12200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-deoxymugineic-acid 2'-dioxygenase"
RHEA:12200	skos:altLabel	"IDS3"
REACT:R-DME-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Drosophila melanogaster)
REACT:R-XTR-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Xenopus tropicalis)
RHEA:22968	skos:prefLabel	"butanal dehydrogenase"
RHEA:22968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + CoA + NAD(+) = butanoyl-CoA + H(+) + NADH
RHEA:22968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"butanal dehydrogenase"
RHEA:22968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + CoA + NADP(+) = butanoyl-CoA + H(+) + NADPH
RHEA:41178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) <=> methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine
RHEA:13151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + NADP(+) => A + H(+) + NADPH
RHEA:69862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in 12S rRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-5668714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX1 complex (Gallus gallus)
REACT:R-HSA-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Homo sapiens)
REACT:R-HSA-9027598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3 (Homo sapiens)
RHEA:53869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + phenazine-1-carboxylate => 1-hydroxyphenazine + CO2 + H2O + NAD(+)
REACT:R-HSA-5655348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)
RHEA:44401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-6 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-6
RHEA:65303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chrodrimanin C + O2 <=> CO2 + H2O + succinate + verruculide A
REACT:R-CEL-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Caenorhabditis elegans)
RHEA:43173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine
RHEA:69432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine = 3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine
REACT:R-HSA-193669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to p75NTR:NRIF (Homo sapiens)
RHEA:45072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Mus musculus)
RHEA:47371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)
REACT:R-BTA-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Bos taurus)
REACT:R-GGA-9756169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)
REACT:R-HSA-1364044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR:JAK2 dimerizes (Homo sapiens)
REACT:R-MMU-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Mus musculus)
REACT:R-HSA-173709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C7 binds C5b:C6 (Homo sapiens)
RHEA:41921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)
REACT:R-BTA-6809006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Bos taurus)
REACT:R-HSA-9736959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)
REACT:R-BTA-4085994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates SIN3A with SUMO1 (Bos taurus)
REACT:R-CEL-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Caenorhabditis elegans)
GO:0047075	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridine-2,5-diol dioxygenase activity
GO:0047075	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity
GO:0047075	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-dihydroxypyridine oxygenase activity
GO:0047075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxypyridine 5,6-dioxygenase activity
REACT:R-RNO-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Rattus norvegicus)
GO:0016882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Cyclo-ligases"
GO:0016882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo-ligase activity
GO:0016882	skos:prefLabel	"Cyclo-ligases"
REACT:R-CEL-9018868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Caenorhabditis elegans)
RHEA:56516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b
RHEA:56516	skos:altLabel	"coproheme III oxidative decarboxylase"
RHEA:56516	skos:prefLabel	"hydrogen peroxide-dependent heme synthase"
RHEA:56516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrogen peroxide-dependent heme synthase"
REACT:R-HSA-4719413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO2 (Homo sapiens)
REACT:R-GGA-5693549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Gallus gallus)
REACT:R-MMU-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Mus musculus)
REACT:R-SSC-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Sus scrofa)
REACT:R-GGA-380455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CDK11p58 to the centrosomes (Gallus gallus)
REACT:R-SSC-159733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor X to factor X (Sus scrofa)
REACT:R-SSC-201603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of PKC theta (Sus scrofa)
REACT:R-HSA-2660815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 (Homo sapiens)
REACT:R-SSC-376851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Sus scrofa)
GO:0098808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA cap binding
REACT:R-RNO-9635743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 binds p-T,Y-MAPK (Rattus norvegicus)
REACT:R-MMU-1638032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Mus musculus)
REACT:R-XTR-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Xenopus tropicalis)
REACT:R-XTR-879562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Xenopus tropicalis)
RHEA:30860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dITP + H2O => dIDP + H(+) + phosphate
REACT:R-BTA-5618085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)
REACT:R-DDI-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Dictyostelium discoideum)
RHEA:55256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-5676596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds BAFFR:BAFF (Canis familiaris)
RHEA:72745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene C4(in) => leukotriene C4(out)
REACT:R-BTA-157849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes containing mRNA that does not circularize (Bos taurus)
REACT:R-DME-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Drosophila melanogaster)
REACT:R-HSA-192851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vRNA Extension (Homo sapiens)
REACT:R-BTA-77340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Bos taurus)
REACT:R-CFA-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)
REACT:R-XTR-936390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD mediated deubiquitination of DDX58 (RIG-I) (Xenopus tropicalis)
REACT:R-BTA-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Bos taurus)
REACT:R-DME-429730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Drosophila melanogaster)
REACT:R-GGA-451516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated MEK2 phosphorylates ERK2 (Gallus gallus)
RHEA:22495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formimidoyl-L-glutamate <=> formamide + L-glutamate
REACT:R-CFA-9619376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK1 binds calmodulin (Canis familiaris)
RHEA:53331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2,3-diacyl-alpha-D-glucosamine <=> 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP
REACT:R-MMU-8939323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 binds BCL10 and Ubiquitin:E2 (Mus musculus)
REACT:R-HSA-5205681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is cleaved on healthy mitochondria (Homo sapiens)
REACT:R-GGA-198609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates TSC2, inhibiting it (Gallus gallus)
REACT:R-SPO-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Schizosaccharomyces pombe)
RHEA:63224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol
REACT:R-XTR-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Xenopus tropicalis)
REACT:R-HSA-1497855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)
REACT:R-BTA-191972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)
REACT:R-MTU-964939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of shikimate (Mycobacterium tuberculosis)
RHEA:70077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine
RHEA:69631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
REACT:R-CFA-8985914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Canis familiaris)
RHEA:28700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mn(2+)(in) => Mn(2+)(out)
REACT:R-CFA-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Canis familiaris)
RHEA:18404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8951951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds EP300 (Homo sapiens)
REACT:R-RNO-380508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NuMA to the centrosomes (Rattus norvegicus)
REACT:R-XTR-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Xenopus tropicalis)
GO:0140439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-cysteine S-stearoyltransferase activity
GO:0140439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein]
REACT:R-DME-5676917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Drosophila melanogaster)
REACT:R-DRE-170861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimeric TGF-beta-1 binds to the receptor (Danio rerio)
REACT:R-DRE-170055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Danio rerio)
RHEA:13079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + D-hexose phosphate + H(+) => an acyl phosphate + D-hexose
REACT:R-CFA-532603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin mediated activation of N-WASP (Canis familiaris)
RHEA:13784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)
RHEA:20784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + L-arginine
RHEA:67987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-leucine <=> N-acetyl-D-leucine
REACT:R-HSA-5661474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)
REACT:R-BTA-8942208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOXE3 isomerises 12R-HpETE to HXA3 (Bos taurus)
RHEA:41240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine
REACT:R-XTR-5218645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 binds p-Y397-PTK2 (Xenopus tropicalis)
RHEA:36725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + AH2 + NH4(+) => 2-phenylethylamine + A + H2O
RHEA:35650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP <=> 3',3'-cGAMP + 2 diphosphate
REACT:R-DDI-70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Dictyostelium discoideum)
GO:0042988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	X11-like protein binding
GO:0042988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	X11L binding
REACT:R-MMU-6814153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADO oxidises 2AET to HTAU (Mus musculus)
REACT:R-GGA-1170539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor is internalized (Gallus gallus)
RHEA:19741	skos:prefLabel	"formyl-CoA hydrolase"
RHEA:19741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formyl-CoA hydrolase"
RHEA:19741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + H2O = CoA + formate + H(+)
REACT:R-CFA-5607732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TAK1 autophosphorylates (Canis familiaris)
REACT:R-GGA-5654596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)
REACT:R-BTA-209536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkB is ubiquitinated and degraded (Bos taurus)
REACT:R-SCE-4568863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RAD52 with SUMO1 (Saccharomyces cerevisiae)
REACT:R-DRE-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Danio rerio)
REACT:R-MMU-4084989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Mus musculus)
GO:0031805	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 8 metabotropic glutamate receptor ligand
GO:0031805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 8 metabotropic glutamate receptor binding
REACT:R-SCE-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Saccharomyces cerevisiae)
RHEA:63358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2 => (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2
REACT:R-RNO-5662692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is oxidized to dopaquinone by TYR (Rattus norvegicus)
RHEA:53690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O
RHEA:37640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-DRE-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Danio rerio)
RHEA:58760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)
REACT:R-CEL-375790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Caenorhabditis elegans)
GO:0102424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity
RHEA:47545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline betaine => cis-4-hydroxy-D-proline betaine
RHEA:51475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-1638032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Bos taurus)
RHEA:66500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
RHEA:47788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 28S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:32557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O
EC:2.1.1.260	skos:prefLabel	"rRNA small subunit pseudouridine methyltransferase Nep1"
EC:2.1.1.260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rRNA small subunit pseudouridine methyltransferase Nep1"
GO:0018742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxide hydrolase B activity
GO:0050547	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)
GO:0050547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vanillin synthase activity
GO:0050547	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)
RHEA:41500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine
RHEA:10757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + phosphate + pyruvate => AMP + diphosphate + H(+) + phosphoenolpyruvate
RHEA:36643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	emodin + S-adenosyl-L-methionine = H(+) + questin + S-adenosyl-L-homocysteine
RHEA:36643	skos:prefLabel	"emodin O-methyltransferase"
RHEA:36643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"emodin O-methyltransferase"
REACT:R-MMU-1474158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCHFR binds to GCH1 and negatively regulates its activity (Mus musculus)
REACT:R-PFA-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Plasmodium falciparum)
REACT:R-HSA-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)
RHEA:32664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine => 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine
RHEA:61492	skos:prefLabel	"ultra-long-chain ceramide synthase"
RHEA:61492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ultra-long-chain ceramide synthase"
RHEA:61492	skos:altLabel	"mammalian ceramide synthase 3"
RHEA:61492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + an ultra-long-chain fatty acyl-CoA = an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)
RHEA:61492	skos:altLabel	"sphingoid base N-ultra-long-chain fatty acyl-CoA transferase"
REACT:R-CFA-6804379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds TTC5 (Canis familiaris)
REACT:R-MMU-9638127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G6P to G1P (Mus musculus)
RHEA:55090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine => eburicol + S-adenosyl-L-methionine
RHEA:35508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:63929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-RNO-934559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is phosphorylated by phosphorylated MNK1 (Rattus norvegicus)
REACT:R-DRE-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Danio rerio)
RHEA:52722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+) => 5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O
GO:0004837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine carboxy-lyase activity
GO:0004837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-(-)-tyrosine apodecarboxylase activity
GO:0004837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine decarboxylase activity
GO:0004837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine carboxy-lyase (tyramine-forming)
GO:0004837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine decarboxylase activity
REACT:R-CFA-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)
RHEA:70587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) = acetate + alpha-D-glucosaminyl-[heparan sulfate](n)
RHEA:48455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA2 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine
REACT:R-MMU-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
RHEA:24299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + H2O <=> H(+) + N-carbamoyl-L-aspartate
GO:1990651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity
REACT:R-HSA-2314569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi (Homo sapiens)
REACT:R-MMU-9696268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds effectors (Mus musculus)
GO:0102889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-elemene synthase activity
RHEA:44675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
RHEA:67974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ecdysone 22-phosphate + H(+) => ATP + ecdysone
RHEA:50596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[histone H4] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]
RHEA:42789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:62525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(839) in 12S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine
RHEA:44395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:42983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine <=> 2-aminoprop-2-enoate + phenol
REACT:R-MMU-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Mus musculus)
REACT:R-CFA-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Canis familiaris)
RHEA:33070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine 1-phosphate + H2O <=> (4R)-hydroxysphinganine + phosphate
RHEA:72475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)
RHEA:31113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexanoyl-CoA + CoA => acetyl-CoA + butanoyl-CoA
REACT:R-DME-9609742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Drosophila melanogaster)
RHEA:70407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 = (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine
RHEA:55776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP
RHEA:54145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 => 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate
RHEA:40545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DDI-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Dictyostelium discoideum)
REACT:R-XTR-110011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Grb10 to the insulin receptor (Xenopus tropicalis)
REACT:R-MMU-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Mus musculus)
RHEA:24337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + ATP + CoA => AMP + an acyl-CoA + diphosphate
REACT:R-SSC-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Sus scrofa)
REACT:R-BTA-1168643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCP ubiquitinylates IkB (Bos taurus)
GO:0005262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium channel activity
REACT:R-CFA-5625416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anterograde IFT (Canis familiaris)
REACT:R-DDI-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Dictyostelium discoideum)
RHEA:56989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8985973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Homo sapiens)
RHEA:41416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:61703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-5'-AMP + holo-[peptidyl-carrier protein] <=> AMP + glycyl-[peptidyl-carrier protein] + H(+)
GO:0036467	skos:altLabel	"5-hydroxytryptophan decarboxylase"
GO:0036467	skos:prefLabel	"aromatic-L-amino-acid decarboxylase"
GO:0036467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-L-tryptophan decarboxylase activity
GO:0036467	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	5-hydroxytryptophan decarboxylase activity
GO:0036467	skos:altLabel	"hydroxytryptophan decarboxylase"
GO:0036467	skos:altLabel	"L-DOPA decarboxylase"
GO:0036467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-L-tryptophan + H(+) = CO2 + serotonin
GO:0036467	skos:altLabel	"aromatic amino acid decarboxylase"
GO:0036467	skos:altLabel	"tryptophan decarboxylase"
GO:0036467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aromatic-L-amino-acid decarboxylase"
GO:0036467	skos:altLabel	"DOPA decarboxylase"
REACT:R-XTR-5686642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD52 promotes single strand annealing at resected DNA DSBs (Xenopus tropicalis)
RHEA:72766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A10 + malonyl-CoA <=> anthocyanin A11 + CoA
RHEA:42538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(65) in tRNA => uridine(65) in tRNA
RHEA:23889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine => [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate
REACT:R-XTR-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Xenopus tropicalis)
REACT:R-HSA-9018880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Homo sapiens)
RHEA:66702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA
REACT:R-DRE-8952128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TP53 (Danio rerio)
GO:0005367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Homo sapiens)
GO:0005367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol:sodium symporter activity
GO:0005367	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	myo-inositol-sodium cotransporter activity
REACT:R-MMU-5340226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB dioxygenates NO (Mus musculus)
REACT:R-SSC-193713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Sus scrofa)
REACT:R-MMU-388831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CD28 (Mus musculus)
REACT:R-HSA-8853391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc (Man)5 translocates from cytosol to lysosomal lumen (Homo sapiens)
RHEA:16179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + retinoate => H2O + NAD(+) + retinal
REACT:R-CFA-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Canis familiaris)
GO:0140662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent protein folding chaperone
REACT:R-GGA-5654402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
REACT:R-SSC-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Sus scrofa)
RHEA:15653	skos:altLabel	"phosphofructokinase 2"
RHEA:15653	skos:prefLabel	"6-phosphofructo-2-kinase"
RHEA:15653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-phosphofructo-2-kinase"
RHEA:15653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate + H(+)
RHEA:70817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-histidine(out) + L-ornithine(in) => H(+)(in) + L-histidine(in) + L-ornithine(out)
REACT:R-HSA-204008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
REACT:R-RNO-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Rattus norvegicus)
RHEA:25220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + serotonin <=> CoA + H(+) + N-acetylserotonin
REACT:R-SSC-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Sus scrofa)
RHEA:15149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate
RHEA:63694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucuronoside + H(+) + UDP => alcohol glucuronate acceptor + UDP-alpha-D-glucuronate
REACT:R-MMU-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Mus musculus)
REACT:R-CFA-193700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR ICD signals to NF-kB (Canis familiaris)
REACT:R-XTR-2022411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)
RHEA:28284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-macrocarpene => (S)-beta-bisabolene
REACT:R-DRE-8985973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Danio rerio)
RHEA:37344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 2'-phosphate + H2O => adenosine + phosphate
REACT:R-BTA-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Bos taurus)
GO:0034004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacradienol synthase activity
GO:0034004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity
RHEA:66747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-aspartate(in) <=> ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate
REACT:R-CFA-1169403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 ligase with ISG15:E2 complex (Canis familiaris)
REACT:R-GGA-433599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Gallus gallus)
REACT:R-CFA-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Canis familiaris)
REACT:R-SSC-870477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Sus scrofa)
GO:0102529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-methyltransferase activity
RHEA:59282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-asparagine => L-asparagine
REACT:R-DME-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Drosophila melanogaster)
RHEA:53391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP
REACT:R-CFA-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Canis familiaris)
RHEA:64014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine
REACT:R-HSA-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)
RHEA:15400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichloromethane + H2O <=> 2 chloride + formaldehyde + 2 H(+)
REACT:R-GGA-6798489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A7 or S100A7A binds Zn2+ (Gallus gallus)
RHEA:34956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(methylsulfanyl)-D-ribose(in) => 5-(methylsulfanyl)-D-ribose(out)
REACT:R-BTA-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Bos taurus)
RHEA:52792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + 2 H(+) = Mg(2+) + pheophorbide a
REACT:R-MMU-6791221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Mus musculus)
REACT:R-XTR-5252041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Xenopus tropicalis)
REACT:R-DME-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)
RHEA:22346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-rosmarinate + CoA => (2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA
REACT:R-BTA-390595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Troponin-C (Bos taurus)
REACT:R-SSC-1254251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds YAP1 (Sus scrofa)
REACT:R-SSC-5362427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds GPC5 (Sus scrofa)
RHEA:41755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)
REACT:R-RNO-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Rattus norvegicus)
GO:0098604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AdeSeHCys is hydrolysed to SeHCys by AHCY (Homo sapiens)
GO:0098604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylselenohomocysteinase activity
RHEA:14761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA
RHEA:14761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine C-palmitoyltransferase"
RHEA:14761	skos:prefLabel	"serine C-palmitoyltransferase"
REACT:R-BTA-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Bos taurus)
RHEA:63715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-GGA-159843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)
RHEA:59610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + L-lysine => beta-alanyl-L-lysine + H2O
REACT:R-BTA-430096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds filamin (Bos taurus)
REACT:R-HSA-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Homo sapiens)
REACT:R-HSA-177690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
REACT:R-RNO-1964496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds TRIM32 or TRIM56  (Rattus norvegicus)
REACT:R-BTA-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Bos taurus)
REACT:R-DRE-8869568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM1 binds TFAP2A homodimer (Danio rerio)
REACT:R-RNO-349455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MDM4 by ATM (Rattus norvegicus)
REACT:R-MMU-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Mus musculus)
REACT:R-BTA-163217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)
RHEA:15323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:71067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-phenylalanine(out) = L-arginine(out) + L-phenylalanine(in)
REACT:R-GGA-201515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK recruits PI3K (Gallus gallus)
RHEA:60237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate
REACT:R-CFA-2730882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC-theta (Canis familiaris)
REACT:R-GGA-5638009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Gallus gallus)
REACT:R-HSA-193686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with IRAK:MYD88 (Homo sapiens)
RHEA:35358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisopentadecanoyl-CoA <=> (2E)-13-methyltetradecenoyl-CoA + H2O
RHEA:21710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + L-homocysteine => H2O + S-adenosyl-L-homocysteine
REACT:R-DRE-2066779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Danio rerio)
GO:0047012	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
GO:0047012	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity
GO:0047012	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol 4-alpha-carboxylic decarboxylase activity
GO:0047012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity
GO:0047012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
GO:0047012	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity
RHEA:51019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-phosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate
RHEA:48645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 => (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde
RHEA:35670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)
RHEA:11784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate
REACT:R-SSC-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Sus scrofa)
REACT:R-SSC-9708558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Sus scrofa)
REACT:R-MMU-2485182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Mus musculus)
REACT:R-RNO-2025890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds NFATC1,2,3 (Rattus norvegicus)
RHEA:32053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-tetraphosphate + AMP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate
REACT:R-BTA-202702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD177 binds PECAM-1 (Bos taurus)
REACT:R-CFA-139906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of BAD by calcineurin (Canis familiaris)
RHEA:43028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteate = 2-aminoprop-2-enoate + H(+) + sulfite
REACT:R-CFA-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)
REACT:R-XTR-211951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1B1 4-hydroxylates EST17b (Xenopus tropicalis)
REACT:R-HSA-8940007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP13 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)
RHEA:18366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate + NAD(+) => CO2 + NADH + pyruvate
REACT:R-RNO-212007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1 4-hydroxylate atRA (Rattus norvegicus)
REACT:R-DRE-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Danio rerio)
RHEA:62297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) => (+)-malbrancheamide + 2 FADH2
REACT:R-SSC-1605595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Sus scrofa)
REACT:R-DRE-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Danio rerio)
REACT:R-DRE-198599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MDM2 (Danio rerio)
REACT:R-CFA-750988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (z) reassociates with G beta:gamma (Canis familiaris)
REACT:R-HSA-8868340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5:p25 phosphorylates lamin B1 (Homo sapiens)
REACT:R-MMU-1676174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Mus musculus)
REACT:R-RNO-9753285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 monooxygenates APAP to NAPQI (Rattus norvegicus)
RHEA:55768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP
RHEA:49512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(phosphinatomethylidene)butanedioate + H2O = phosphinomethylisomalate
REACT:R-HSA-1236968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Egress of internalized antigen into cytosol from early endosome (Homo sapiens)
REACT:R-RNO-71335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Rattus norvegicus)
RHEA:50699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CEL-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Caenorhabditis elegans)
REACT:R-HSA-9681169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRBN binds IMiDs (Homo sapiens)
REACT:R-SSC-165182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of complexed TSC2 by PKB (Sus scrofa)
REACT:R-RNO-141409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mad1 binds kinetochore (Rattus norvegicus)
RHEA:56713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] => H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate
RHEA:61903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + betaenone C <=> A + betaenone B
RHEA:53453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester
REACT:R-XTR-2187355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters phosphorylated SMAD2/3 (Xenopus tropicalis)
RHEA:32870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol(out) <=> myo-inositol(in)
REACT:R-HSA-6802165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the PLK3 gene (Homo sapiens)
REACT:R-MMU-8950405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Mus musculus)
RHEA:45110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:30089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + FADH2 => (S)-2-hydroxyglutarate + FAD + H(+)
REACT:R-CFA-8952128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TP53 (Canis familiaris)
REACT:R-DRE-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Danio rerio)
REACT:R-PFA-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Plasmodium falciparum)
REACT:R-RNO-9013111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GAPs stimulate RHOC GTPase activity (Rattus norvegicus)
RHEA:65541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + H2O => an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose
REACT:R-SSC-8941618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
REACT:R-SSC-975608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP2:atROL and FACYLs to atREs (Sus scrofa)
REACT:R-SSC-9749590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates ALB (Sus scrofa)
REACT:R-RNO-6806610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filament formation (Rattus norvegicus)
RHEA:25137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyridoxamine 5'-phosphate => phosphate + pyridoxamine
GO:0004106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate mutase activity
GO:0004106	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxyphenylpyruvate synthase activity
GO:0004106	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chorismate pyruvatemutase activity
REACT:R-HSA-1566962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by elastin-degrading extracellular proteinases (Homo sapiens)
REACT:R-GGA-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Gallus gallus)
REACT:R-CFA-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Canis familiaris)
REACT:R-SCE-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-GGA-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Gallus gallus)
REACT:R-RNO-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Rattus norvegicus)
RHEA:32229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADPHX => (6R)-NADPHX
RHEA:19018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADHX + ATP => ADP + H(+) + NADH + phosphate
REACT:R-XTR-398040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma activation of PLC beta (Xenopus tropicalis)
RHEA:50664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)
RHEA:33340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine
RHEA:43277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GalNAc-GD1a + H(+) + UDP
RHEA:51222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione
RHEA:33053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H(+) + NADH => choline + NAD(+)
REACT:R-RNO-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Rattus norvegicus)
RHEA:52553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-erythronate + ATP => 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)
REACT:R-HSA-204871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb2 (Homo sapiens)
GO:0032441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pheophorbide a oxygenase activity
RHEA:51979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinate + 2 H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + H2O + NADP(+)
REACT:R-DDI-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Dictyostelium discoideum)
REACT:R-DDI-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Dictyostelium discoideum)
REACT:R-CEL-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Caenorhabditis elegans)
REACT:R-XTR-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Xenopus tropicalis)
RHEA:64331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (7Z)-octadecenoate + CoA
REACT:R-CFA-6805638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A acetylates TP53 (Canis familiaris)
REACT:R-CFA-2046096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Canis familiaris)
RHEA:27641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + xanthosine <=> alpha-D-ribose 1-phosphate + xanthine
REACT:R-BTA-182594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of INK4 family proteins with CDK4/6 (Bos taurus)
RHEA:12838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + choline => ADP + H(+) + phosphocholine
RHEA:30961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,9,9'-tri-cis-neurosporene + a quinol => 9,9'-di-cis-zeta-carotene + a quinone
REACT:R-CFA-8983834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Canis familiaris)
REACT:R-CFA-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Canis familiaris)
RHEA:22434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxoacyl-CoA + H(+) + NADH => a (3S)-3-hydroxyacyl-CoA + NAD(+)
REACT:R-HSA-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Homo sapiens)
RHEA:38427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate
RHEA:62566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-perillyl alcohol + AH2 => (4S)-limonene + A + H2O
REACT:R-XTR-77299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)
RHEA:71583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out)
RHEA:66756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + domoate(in) + H2O = ADP + domoate(out) + H(+) + phosphate
REACT:R-HSA-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Homo sapiens)
REACT:R-BTA-203553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS binds NOSIP (Bos taurus)
REACT:R-BTA-6809015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)
REACT:R-CFA-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Canis familiaris)
REACT:R-CFA-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Canis familiaris)
RHEA:69221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-glucosinolate + H2O => a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)
REACT:R-DDI-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Dictyostelium discoideum)
REACT:R-XTR-72185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA polyadenylation (Xenopus tropicalis)
RHEA:21577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine + H(+) => 2-methylcholine + CO2
GO:0042301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate ion binding
REACT:R-MMU-5654148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR3 (Mus musculus)
REACT:R-SSC-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Sus scrofa)
RHEA:54162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2
REACT:R-DME-1678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses CS/HS precursor (Drosophila melanogaster)
RHEA:15397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dichloromethane dehalogenase"
RHEA:15397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichloromethane + H2O = 2 chloride + formaldehyde + 2 H(+)
RHEA:15397	skos:prefLabel	"dichloromethane dehalogenase"
REACT:R-BTA-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)
REACT:R-RNO-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Rattus norvegicus)
RHEA:40264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH
REACT:R-CFA-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Canis familiaris)
RHEA:25855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-PFA-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Plasmodium falciparum)
RHEA:15451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-maleylacetoacetate + H(+) => homogentisate + O2
REACT:R-HSA-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)
GO:0140481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled Fe-S cluster transmembrane transporter activity
GO:0140481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type iron-sulfur cluster transporter activity
GO:0140481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled iron-sulfur cluster transmembrane transporter activity
REACT:R-XTR-4551724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 (Xenopus tropicalis)
EC:3.4.13.9	skos:altLabel	"peptidase D"
EC:3.4.13.9	skos:altLabel	"prolidase"
EC:3.4.13.9	skos:altLabel	"proline dipeptidase"
EC:3.4.13.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Xaa-Pro dipeptidase"
EC:3.4.13.9	skos:altLabel	"X-Pro dipeptidase"
EC:3.4.13.9	skos:prefLabel	"Xaa-Pro dipeptidase"
EC:3.4.13.9	skos:altLabel	"gamma-peptidase"
EC:3.4.13.9	skos:altLabel	"imidodipeptidase"
RHEA:24327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocineole + H(+) + NADPH + O2 <=> 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)
REACT:R-GGA-217017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitination of FancD2 (Gallus gallus)
RHEA:28080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + phosphonoacetaldehyde => 2-hydroxyethylphosphonate + NAD(+)
REACT:R-DRE-2161948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Danio rerio)
RHEA:66685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] => L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]
REACT:R-HSA-5603275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective TBXAS1 does not isomerise PGH2 to TXA2 (Homo sapiens)
REACT:R-XTR-443774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homodimerization of Neurofascin (Xenopus tropicalis)
RHEA:28984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite(in) => nitrite(out)
GO:1902444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin binding
REACT:R-DDI-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Dictyostelium discoideum)
REACT:R-MMU-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Mus musculus)
REACT:R-RNO-450971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Rattus norvegicus)
REACT:R-XTR-8985343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SOX9 (Xenopus tropicalis)
RHEA:19986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + S-(hydroxymethyl)glutathione => H(+) + NADH + S-formylglutathione
REACT:R-CFA-9605600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Canis familiaris)
REACT:R-BTA-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Bos taurus)
RHEA:52219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1''->2')-ADP-alpha-D-ribose](n) + H2O <=> [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose
RHEA:58577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate + NADP(+) => H(+) + NADPH + precondylocarpine acetate
REACT:R-HSA-1268022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space (Homo sapiens)
REACT:R-SCE-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Saccharomyces cerevisiae)
GO:0008770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AcpH
GO:0008770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity
GO:0008770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[acyl-carrier protein] phosphodiesterase activity
GO:0008770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP phosphodiesterase activity
GO:0008770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-carrier-protein phosphodiesterase activity
GO:0008770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity
GO:0008770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[acyl-carrier-protein] phosphodiesterase activity
GO:0008770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity
GO:0008770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACP hydrolyase activity
RHEA:18550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP
REACT:R-HSA-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Homo sapiens)
REACT:R-HSA-389756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT interacts and phosphorylates Cot (Homo sapiens)
RHEA:14422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-benzoyl-D-arginine-4-nitroanilide => 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine
REACT:R-SPO-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Schizosaccharomyces pombe)
RHEA:29902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-xylose(out) + H2O <=> ADP + D-xylose(in) + H(+) + phosphate
REACT:R-DRE-174202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Securin (Danio rerio)
REACT:R-GGA-1472121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of p-KIT on Y900 by Src kinases (Gallus gallus)
RHEA:54669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-alpha-onocerin => alpha-onocerin
REACT:R-HSA-159761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Homo sapiens)
RHEA:14357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + riboflavin = ADP + FMN + H(+)
RHEA:14357	skos:prefLabel	"riboflavin kinase"
RHEA:14357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"riboflavin kinase"
RHEA:14357	skos:altLabel	"RFK"
RHEA:14357	skos:altLabel	"flavokinase"
RHEA:15661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanin 5-(6'''-hydroxycinnamoyltransferase)"
RHEA:15661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside = an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA
RHEA:15661	skos:prefLabel	"anthocyanin 5-(6'''-hydroxycinnamoyltransferase)"
REACT:R-CFA-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Canis familiaris)
RHEA:28623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol
REACT:R-HSA-3656267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
REACT:R-HSA-2029983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of FGFR2 ligand-independent mutants (Homo sapiens)
REACT:R-SSC-2327746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 aggregation (Sus scrofa)
RHEA:62223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phyllostine <=> neopatulin
REACT:R-BTA-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Bos taurus)
REACT:R-GGA-2545203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cleaved cohesin (Gallus gallus)
REACT:R-CEL-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)
RHEA:32368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone => 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate
REACT:R-CFA-204863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang2 (Canis familiaris)
REACT:R-DME-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Drosophila melanogaster)
RHEA:25787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-rhamnonate <=> (S)-lactaldehyde + pyruvate
RHEA:54291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tyrosyl-[protein] <=> diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]
REACT:R-CFA-6786101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4 binds IL4R:JAK2 (Canis familiaris)
REACT:R-DRE-6783524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM,LIF,CTF1 receptor complex binds gp130 (Danio rerio)
RHEA:49290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+) => (R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein]
RHEA:38783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
GO:0018658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylate 1-monooxygenase activity
GO:0018658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
GO:0018658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	salicylate 1-hydroxylase activity
GO:0018658	skos:prefLabel	"salicylate 1-monooxygenase"
GO:0018658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	salicylic hydroxylase activity
GO:0018658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	salicylate hydroxylase (decarboxylating)
GO:0018658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	salicylate monooxygenase activity
GO:0018658	skos:altLabel	"Salicylic hydroxylase"
GO:0018658	skos:altLabel	"salicylate hydroxylase"
GO:0018658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salicylate 1-monooxygenase"
GO:0018658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + salicylate = catechol + CO2 + H2O + NAD(+)
GO:0018658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylate hydroxylase activity
REACT:R-BTA-419334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melatonin receptors can bind melatonin (Bos taurus)
RHEA:38638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-HSA-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Homo sapiens)
RHEA:23234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(II)-[cytochrome c] + 4 H(+) + N2 => 4 Fe(III)-[cytochrome c] + hydrazine
REACT:R-DME-169827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPDK1 phosphorylates and activates DS6K (Drosophila melanogaster)
REACT:R-HSA-1855172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Homo sapiens)
RHEA:19808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine D-ribonucleoside + phosphate <=> a purine nucleobase + alpha-D-ribose 1-phosphate
REACT:R-HSA-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Homo sapiens)
RHEA:59150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + marinoloyl-CoA C => ATP + CoA + marinolate C
RHEA:45257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate(out) => hexadecanoate(in)
GO:0002059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine binding
REACT:R-MMU-77586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Mus musculus)
RHEA:67026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine
REACT:R-MMU-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Mus musculus)
RHEA:57872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2,4-dihydroxycinnamoyl-CoA = CoA + umbelliferone
RHEA:55885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[aequorin] + 3 Ca(2+) => [aequorin]--dioxetanone
EC:3.4.21.39	skos:prefLabel	"chymase"
EC:3.4.21.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chymase"
EC:3.4.21.39	skos:altLabel	"mast cell protease I"
EC:3.4.21.39	skos:altLabel	"skeletal muscle (SK) protease"
RHEA:68593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O => (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate
REACT:R-RNO-216064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha8beta1 with Tenascin-C (Rattus norvegicus)
REACT:R-DRE-196372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Danio rerio)
RHEA:59489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:65376	skos:prefLabel	"NNS virus cap methyltransferase"
RHEA:65376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NNS virus cap methyltransferase"
RHEA:65376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-RNO-5626220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 binds the mother centriole (Rattus norvegicus)
REACT:R-HSA-9014610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
REACT:R-XTR-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Xenopus tropicalis)
RHEA:38516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)
REACT:R-HSA-9757441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- (GI) translocates from cytosol to extracellular region (Homo sapiens)
REACT:R-SSC-1296127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of voltage gated Potassium channels (Sus scrofa)
REACT:R-SSC-9020262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Sus scrofa)
RHEA:11697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-demethylstaurosporine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + staurosporine
EC:3.1.1.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acylglycerol lipase"
EC:3.1.1.23	skos:altLabel	"monoacylglycerol lipase"
EC:3.1.1.23	skos:prefLabel	"acylglycerol lipase"
REACT:R-XTR-9014433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GEFs activate RHOG (Xenopus tropicalis)
RHEA:38667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine 1-phosphate(in) = sphing-4-enine 1-phosphate(out)
REACT:R-DME-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Drosophila melanogaster)
RHEA:28890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-serine(in) <=> H(+)(out) + L-serine(out)
REACT:R-PFA-5688786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds RAD23 (Plasmodium falciparum)
REACT:R-RNO-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Rattus norvegicus)
EC:3.4.21.116	skos:altLabel	"stage IV sporulation protein B"
EC:3.4.21.116	skos:prefLabel	"SpoIVB peptidase"
EC:3.4.21.116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"SpoIVB peptidase"
EC:3.4.21.116	skos:altLabel	"sporulation factor IV B protease"
RHEA:64286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + L-alanine => 2-phenylethylamine + pyruvate
RHEA:35227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + rifampicin(in) = H(+)(in) + rifampicin(out)
GO:0047161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity
GO:0047161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity
GO:0047161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tartronate O-hydroxycinnamoyltransferase activity
GO:0047161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tartronate sinapoyltransferase activity
RHEA:64894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + tetradecanoyl-[ACP] => holo-[ACP] + tetradecanoyl-AMP
REACT:R-HSA-1358797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated RNF41 binds P-USP8 (Homo sapiens)
RHEA:32927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate
RHEA:47380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]
GO:0008109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity
GO:0008109	skos:altLabel	"I-branching beta1,6-N-acetylglucosaminyltransferase"
GO:0008109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity
GO:0008109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase"
GO:0008109	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase
GO:0008109	skos:altLabel	"N-acetylglucosaminyltransferase"
GO:0008109	skos:prefLabel	"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase"
GO:0008109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity
GO:0008109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity
GO:0008109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminyltransferase activity
REACT:R-DME-201821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Drosophila melanogaster)
GO:0071968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid A-core heptosyltransferase activity
REACT:R-BTA-193816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Bos taurus)
RHEA:51282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate
RHEA:25341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + urea <=> isocyanate + NH4(+)
REACT:R-SPO-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Schizosaccharomyces pombe)
REACT:R-BTA-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Bos taurus)
RHEA:46391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 = 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)
RHEA:30513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + NADP(+) => 2-demethylmenaquinone-8 + H(+) + NADPH
RHEA:40248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + rhodomycin D => 10-carboxy-13-deoxycarminomycin + H(+) + methanol
RHEA:44004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl fatty acid + ATP + CoA = a 3-methyl fatty acyl-CoA + AMP + diphosphate
GO:0018422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-mannose:serine-protein mannose-1-phosphotransferase activity
REACT:R-GGA-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Gallus gallus)
REACT:R-DME-193816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Drosophila melanogaster)
REACT:R-SSC-6797974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRTMs bind NRXNs (Sus scrofa)
REACT:R-HSA-9015379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (compounds) binds IIa (Homo sapiens)
RHEA:63032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acylamide + H2O = a fatty acid + NH4(+)
RHEA:25749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
GO:0015928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucosidase activity
REACT:R-SSC-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Sus scrofa)
RHEA:68459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O
GO:0008839	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrodipicolinic acid reductase activity
GO:0008839	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity
GO:0008839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrodipicolinate reductase activity
GO:0008839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-tetrahydrodipicolinate reductase
GO:0008771	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)
GO:0008771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + AMP + diphosphate
GO:0008771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[citrate (pro-3S)-lyase] ligase activity
GO:0008771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate (pro-3S)-lyase ligase activity
GO:0008771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate lyase ligase activity
GO:0008771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[citrate (pro-3S)-lyase] ligase"
GO:0008771	skos:altLabel	"citrate lyase ligase"
GO:0008771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate lyase synthetase activity
GO:0008771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetate:HS-citrate lyase ligase activity
GO:0008771	skos:altLabel	"citrate lyase synthetase"
GO:0008771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetate: SH-acyl-carrier-protein enzyme ligase (AMP)
GO:0008771	skos:prefLabel	"[citrate (pro-3S)-lyase] ligase"
RHEA:44468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine
RHEA:59503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate
REACT:R-XTR-997311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of TYK2 by PTP1B (Xenopus tropicalis)
RHEA:66306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide
GO:0033429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGT codon-amino acid adaptor activity
GO:0033429	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine tRNA
GO:0033429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGU codon-amino acid adaptor activity
REACT:R-MMU-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Mus musculus)
RHEA:53631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate
RHEA:60858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine
RHEA:58109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[protein] => acetate + L-lysyl-[protein]
RHEA:36923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA
RHEA:62720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 NADPH + 3 O2 + probetaenone I = betaenone B + 3 H2O + 3 NADP(+)
REACT:R-XTR-3968414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Xenopus tropicalis)
REACT:R-CEL-9727188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B binds PPIs (Caenorhabditis elegans)
REACT:R-RNO-6803892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds BAX (Rattus norvegicus)
REACT:R-SSC-2160935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 ubiquitinates RHOA (Sus scrofa)
REACT:R-GGA-2404135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4 binds atROL (Gallus gallus)
RHEA:39261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z)-docosadienoyl-CoA + H2O => (3R)-hydroxy-(13Z)-docosenoyl-CoA
REACT:R-DRE-9647977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT methylates S-Farn RAS proteins (Danio rerio)
REACT:R-MMU-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Mus musculus)
RHEA:19278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-pyrrolysine + tRNA(Pyl) => AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)
RHEA:37199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
GO:0004721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoprotein phosphohydrolase activity
GO:0004721	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase-2B activity
GO:0004721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphatase activity
GO:0004721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoprotein phosphatase activity
GO:0004721	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase-2A activity
GO:0004721	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase-2C activity
GO:0004721	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase-1 activity
REACT:R-HSA-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)
REACT:R-MMU-77271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Mus musculus)
REACT:R-GGA-5228521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Gallus gallus)
REACT:R-CEL-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Caenorhabditis elegans)
REACT:R-BTA-975389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Bos taurus)
RHEA:28816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate(in) + H(+)(out) => 4-hydroxybenzoate(out) + H(+)(in)
RHEA:58451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine
RHEA:50758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + oxidized [flavodoxin] => NADP(+) + reduced [flavodoxin]
REACT:R-BTA-4085372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO2,3 (Bos taurus)
REACT:R-GGA-4655431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOyation of DNMT1 with SUMO1 (Gallus gallus)
RHEA:63053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol
REACT:R-HSA-8853898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX binds the CSF1R (M-CSF-R) gene promoter (Homo sapiens)
RHEA:39720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate => 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:51783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlormethylbutanophenone + dimethylallyl diphosphate <=> deoxyadlupulone + diphosphate
REACT:R-XTR-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Xenopus tropicalis)
REACT:R-DME-389995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Drosophila melanogaster)
REACT:R-GGA-1253343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds ERBB4s80 (Gallus gallus)
REACT:R-XTR-5693346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CECRI deaminates Ade-Rib to Ino (Xenopus tropicalis)
RHEA:50680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein N-terminal glutamine amidohydrolase"
RHEA:50680	skos:prefLabel	"protein N-terminal glutamine amidohydrolase"
RHEA:50680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-glutamyl-[protein] + NH4(+)
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl reductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl-acyl-carrier protein(ACP) reductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl acyl carrier protein (ACP) reductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoacyl-acyl-carrier-protein reductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-[acyl-carrier protein] reductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl-ACP reductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl-acyl carrier protein reductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-ACP reductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoacyl-ACPreductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketoacyl acyl carrier protein reductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoacyl thioester reductase activity
GO:0004316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity
REACT:R-RNO-8987141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)
RHEA:32516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)
REACT:R-XTR-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Xenopus tropicalis)
REACT:R-DRE-352174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Danio rerio)
REACT:R-CFA-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)
RHEA:32938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)
REACT:R-MMU-5696131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC1 deaminates Hist (Mus musculus)
RHEA:30023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate
REACT:R-HSA-380158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)
RHEA:61256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteine + O2 = 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)
REACT:R-DRE-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Danio rerio)
RHEA:37737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine
REACT:R-SPO-3371518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 binds to HSF1 (Schizosaccharomyces pombe)
RHEA:61891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diosgenin + UDP-alpha-D-glucose <=> diosgenin 3-O-beta-D-glucoside + H(+) + UDP
REACT:R-XTR-170126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin B1 in the CRS domain (Xenopus tropicalis)
RHEA:26049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:18548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-arabinonate <=> glycolaldehyde + pyruvate
GO:0030747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indolepyruvate methyltransferase activity
GO:0030747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indolepyruvate C-methyltransferase activity
GO:0030747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity
GO:0030747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indolepyruvic acid methyltransferase activity
GO:0030747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity
GO:0030747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indolepyruvate 3-methyltransferase activity
RHEA:20655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitacin B + H(+) + NADH => 23,24-dihydrocucurbitacin B + NAD(+)
REACT:R-DRE-70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Danio rerio)
REACT:R-SSC-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)
RHEA:26121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:56715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] <=> H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate
RHEA:10534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H2O + L-tryptophan => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine
REACT:R-BTA-8851877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Bos taurus)
RHEA:21899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate
RHEA:15644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxaloacetate <=> CO2 + pyruvate
RHEA:38753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
REACT:R-HSA-163843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-GAS6 to GAS6 (Homo sapiens)
REACT:R-HSA-975879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)
REACT:R-HSA-5687360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLL or POLM extends aligned DNA DSB ends to fill gaps (Homo sapiens)
RHEA:25729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SPO-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
GO:0052594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetone:oxygen oxidoreductase(deaminating) activity
REACT:R-RNO-1667005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Rattus norvegicus)
RHEA:54980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)
REACT:R-MMU-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Mus musculus)
REACT:R-DME-9023884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to TGFA promoter (Drosophila melanogaster)
REACT:R-XTR-352119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Xenopus tropicalis)
RHEA:64823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetamide + H2O <=> 2-phenylacetate + NH4(+)
RHEA:57424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guaiacol + O2 + reduced [NADH--hemoprotein reductase] = catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
REACT:R-DRE-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Danio rerio)
REACT:R-BTA-204773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb7 (Bos taurus)
RHEA:56046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)
RHEA:15524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycyl-[protein]
REACT:R-DRE-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Danio rerio)
RHEA:53006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate
RHEA:44031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-altrarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O
REACT:R-DRE-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Danio rerio)
REACT:R-XTR-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Xenopus tropicalis)
REACT:R-GGA-5218839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)
RHEA:61623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose <=> [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)
GO:0016719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carotene 7,8-desaturase activity
GO:0016719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zeta-carotene desaturase activity
GO:0016719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carotene,hydrogen-donor:oxygen oxidoreductase activity
RHEA:59264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-HSA-9749505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC14 binds IKBKB and CHUK (Homo sapiens)
REACT:R-MMU-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Mus musculus)
REACT:R-HSA-2404133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A REH hydrolses atREs to atROL and FAs (Homo sapiens)
REACT:R-MMU-444879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 2 binds relaxin 2 and INSL3 (Mus musculus)
RHEA:34077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + phosphate => an acyl phosphate + sn-glycerol 3-phosphate
RHEA:60248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]
REACT:R-SCE-9696275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds GTP (Saccharomyces cerevisiae)
REACT:R-XTR-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Xenopus tropicalis)
REACT:R-XTR-909721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ISGF3 complex to nucleus (Xenopus tropicalis)
REACT:R-BTA-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Bos taurus)
RHEA:72000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II
REACT:R-SSC-5617182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates PLN (Sus scrofa)
RHEA:68145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl 3-oxobutanoate + H(+) + NADPH => ethyl (R)-3-hydroxybutanoate + NADP(+)
RHEA:68540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate
RHEA:59364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)
REACT:R-DRE-1454822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP1,2,8,13, PRSS2 (Danio rerio)
REACT:R-HSA-9011543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCA binds PDK2 (Homo sapiens)
REACT:R-CEL-2152276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of transmembrane collagens (Caenorhabditis elegans)
REACT:R-HSA-75244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL binds FAS Receptor (Homo sapiens)
GO:0050140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferrocytochrome:nitrate oxidoreductase activity
GO:0050140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate reductase (cytochrome) activity
GO:0050140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzyl viologen-nitrate reductase activity
REACT:R-SPO-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Schizosaccharomyces pombe)
RHEA:58425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hex-2-en-1-ol + NADP(+) => (E)-hex-2-enal + H(+) + NADPH
RHEA:29882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-arginine(out) <=> ADP + H(+) + L-arginine(in) + phosphate
REACT:R-RNO-976810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to extracellular Factor H:C3b (Rattus norvegicus)
REACT:R-RNO-936802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to extracellular region (Rattus norvegicus)
RHEA:12580	skos:prefLabel	"tauropine dehydrogenase"
RHEA:12580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine
RHEA:12580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tauropine dehydrogenase"
REACT:R-SSC-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Sus scrofa)
REACT:R-BTA-5687094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 phosphorylate MAPKAPK5 (Bos taurus)
RHEA:66387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol <=> scalar-17(25)-en-19-ol
RHEA:64492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] = dehydrocitreoisocoumarin + H2O + holo-[ACP]
REACT:R-CEL-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Caenorhabditis elegans)
REACT:R-RNO-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Rattus norvegicus)
REACT:R-CEL-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)
REACT:R-RNO-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Rattus norvegicus)
GO:0046428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate octaprenyltransferase activity
GO:0046428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-Dihydroxy-2-naphtoate prenyltransferase activity
REACT:R-HSA-8875902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC45A3 transports Glc from extracellular region to cytosol (Homo sapiens)
RHEA:70659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N,N-dimethylglycine(in) = H(+)(out) + N,N-dimethylglycine(out)
RHEA:36374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hydroxybutanoate + NAD(+) <=> 2-oxobutanoate + H(+) + NADH
REACT:R-BTA-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Bos taurus)
REACT:R-RNO-430076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds 14-3-3-zeta (Rattus norvegicus)
RHEA:29108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + ubiquinone-8 => NAD(+) + ubiquinol-8
REACT:R-RNO-448421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 translocates from the ER lumen to the extracellular region (Rattus norvegicus)
RHEA:13074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 3'-diphosphate 5'-triphosphate + H2O => guanosine 3',5'-bis(diphosphate) + H(+) + phosphate
REACT:R-DME-9029580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Drosophila melanogaster)
REACT:R-DME-9012315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Drosophila melanogaster)
RHEA:53367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(47) in tRNA + NAD(+) <=> H(+) + NADH + uridine(47) in tRNA
REACT:R-BTA-373339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Bos taurus)
REACT:R-XTR-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)
RHEA:14120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate
REACT:R-DRE-177275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates DARPP-32 on Thr34 (Danio rerio)
RHEA:28341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinyl-CoA <=> crotonobetainyl-CoA + H2O
RHEA:24165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]
RHEA:23257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine => adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate
REACT:R-DME-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Drosophila melanogaster)
REACT:R-RNO-9693324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disulfiram covalently modifies Cys191 in GSDMD (Rattus norvegicus)
RHEA:61830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + stigmasteryl 3-beta-D-glucoside + UDP => stigmasterol + UDP-alpha-D-glucose
RHEA:46149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside + H(+) + triphosphate
RHEA:33156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycerol + phosphate
RHEA:13832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
RHEA:19983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + S-formylglutathione => NADP(+) + S-(hydroxymethyl)glutathione
REACT:R-DME-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Drosophila melanogaster)
REACT:R-XTR-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Xenopus tropicalis)
RHEA:30295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + pyruvate = GDP + H(+) + phosphoenolpyruvate
REACT:R-DRE-9731924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds EDNs (Danio rerio)
RHEA:53015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichlorohydroquinone + 2 glutathione <=> chloride + chlorohydroquinone + glutathione disulfide + H(+)
GO:1904483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	synthetic cannabinoid binding
RHEA:54816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)
RHEA:54816	skos:altLabel	"fibrinoligase"
RHEA:54816	skos:prefLabel	"protein-glutamine gamma-glutamyltransferase"
RHEA:54816	skos:altLabel	"transglutaminase"
RHEA:54816	skos:altLabel	"polyamine transglutaminase"
RHEA:54816	skos:altLabel	"glutaminylpeptide gamma-glutamyltransferase"
RHEA:54816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-glutamine gamma-glutamyltransferase"
RHEA:54816	skos:altLabel	"TGase"
GO:0034482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin 2-O-sulphotransferase activity
GO:0034482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin 2-O-sulfotransferase activity
GO:0034482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin 2-sulfotransferase activity
GO:0050118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-L-diaminopimelic acid deacylase activity
GO:0050118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity
GO:0050118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyldiaminopimelate deacetylase activity
GO:0050118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity
GO:0050118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-LL-diaminopimelate deacylase activity
REACT:R-HSA-2396124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds Laminins with gamma-1 subunit (Homo sapiens)
RHEA:72032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + O2 => (E)-sinapaldehyde + H2O2
REACT:R-MMU-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Mus musculus)
RHEA:53694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O
RHEA:68231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + Na(+)(in) <=> glycine(out) + Na(+)(out)
REACT:R-DME-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)
REACT:R-MMU-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Mus musculus)
GO:0070553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinic acid receptor activity
GO:0070553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	niacin receptor activity
REACT:R-SSC-4084982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Sus scrofa)
REACT:R-DME-5690856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Drosophila melanogaster)
RHEA:61966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:63047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mevastatin <=> H(+) + mevinic carboxylate
RHEA:39588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)
RHEA:66576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 4-isopropylphenol = 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:61109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-211966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2D6 4-hydroxylates debrisoquine (Sus scrofa)
REACT:R-BTA-5358336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB forms mixed disulphides with Hh precursors (Bos taurus)
REACT:R-SCE-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Saccharomyces cerevisiae)
REACT:R-DDI-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Dictyostelium discoideum)
RHEA:23092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + hydroxyatrazine = ethylamine + N-isopropylammelide
RHEA:23092	skos:altLabel	"hydroxyatrazine hydrolase"
RHEA:23092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxydechloroatrazine ethylaminohydrolase"
RHEA:23092	skos:prefLabel	"hydroxydechloroatrazine ethylaminohydrolase"
RHEA:23092	skos:altLabel	"2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase"
REACT:R-CEL-73806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIR + CO2 => CAIR (Caenorhabditis elegans)
REACT:R-GGA-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Gallus gallus)
REACT:R-BTA-9025999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Bos taurus)
REACT:R-XTR-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Xenopus tropicalis)
RHEA:19941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-norcoclaurine + S-adenosyl-L-methionine = (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine
RHEA:19941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(RS)-norcoclaurine 6-O-methyltransferase"
RHEA:19941	skos:prefLabel	"(RS)-norcoclaurine 6-O-methyltransferase"
RHEA:19941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norcoclaurine + S-adenosyl-L-methionine = coclaurine + H(+) + S-adenosyl-L-homocysteine
RHEA:23108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinono-1,4-lactone + H2O = D-arabinonate + H(+)
RHEA:23108	skos:prefLabel	"D-arabinonolactonase"
RHEA:23108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arabinonolactonase"
RHEA:43163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine
REACT:R-HSA-2033472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c mutants bind an expanded range of ligands (Homo sapiens)
REACT:R-SSC-5693551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BRCA1-A complex at multiple sites by ATM (Sus scrofa)
REACT:R-MMU-4551727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Mus musculus)
REACT:R-XTR-2179387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Xenopus tropicalis)
RHEA:13766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromochloromethane + H2O => bromide + chloride + formaldehyde + 2 H(+)
RHEA:11316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic aldoxime = a nitrile + H2O
REACT:R-XTR-9007901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RL2 (Xenopus tropicalis)
RHEA:10489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP => 5,10-methenyltetrahydrofolate + ADP + phosphate
REACT:R-HSA-8848726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates BCAR1 (Homo sapiens)
REACT:R-HSA-73739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)
REACT:R-BTA-173483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAMBI interferes with the interaction of type I receptor with type II receptor (Bos taurus)
RHEA:71224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + taurine(out) => chloride(in) + 2 Na(+)(in) + taurine(in)
RHEA:36515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + tetracosanoyl-CoA = 3-oxohexacosanoyl-CoA + CO2 + CoA
GO:0046608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carotenoid isomerase activity
RHEA:63669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH
REACT:R-HSA-9634584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Homo sapiens)
RHEA:21977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite => [thioredoxin]-dithiol + adenosine 5'-phosphosulfate
GO:0102052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-proline synthetase activity
REACT:R-CFA-444572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zinc is an agonist of GPR39 (Canis familiaris)
GO:0140733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA ligase activator activity
RHEA:23219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + H(+) + NADPH + O2 <=> 3-hydroxybenzoyl-CoA + H2O + NADP(+)
GO:0050605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rubredoxin:superoxide oxidoreductase activity
GO:0050605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desulfoferrodoxin activity
GO:0050605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	superoxide reductase activity
GO:0050605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neelaredoxin activity
REACT:R-DME-8964619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds ARHGEF6 (Drosophila melanogaster)
RHEA:48496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose = 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP
RHEA:72735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)
RHEA:42200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + NADP(+) = 11-dehydrocorticosterone + H(+) + NADPH
REACT:R-HSA-1067676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)
REACT:R-DME-9632918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Drosophila melanogaster)
RHEA:28241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calycosin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin
REACT:R-DRE-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Danio rerio)
REACT:R-BTA-4570485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO3 (Bos taurus)
REACT:R-HSA-77607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of stem-loop structure in ApoB mRNA (Homo sapiens)
REACT:R-GGA-381412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP2 binds IGF forming IGF:IGFBP2 (Gallus gallus)
RHEA:63661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)
REACT:R-HSA-9770072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds SYT10 gene (Homo sapiens)
REACT:R-HSA-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)
RHEA:56815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 <=> 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate
REACT:R-RNO-451056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Microtubule-independent trafficking of connexons to the plasma membrane (Rattus norvegicus)
GO:0097620	skos:prefLabel	"(R)-mandelate dehydrogenase"
GO:0097620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelate + NAD(+) = H(+) + NADH + phenylglyoxylate
GO:0097620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mandelate dehydrogenase activity
GO:0097620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelate dehydrogenase activity
GO:0097620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-mandelate dehydrogenase"
GO:0097620	skos:altLabel	"D-mandelate dehydrogenase"
REACT:R-CFA-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Canis familiaris)
GO:0018647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene 1,2-monooxygenase activity
REACT:R-CFA-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Canis familiaris)
RHEA:68441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin + O2 => (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal
RHEA:49788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + glycine = CoA + glycochenodeoxycholate + H(+)
RHEA:47755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine <=> 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9020504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds GRIN2B gene promoter (Homo sapiens)
REACT:R-DRE-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Danio rerio)
RHEA:22396	skos:prefLabel	"versatile peroxidase"
RHEA:22396	skos:altLabel	"polyvalent peroxidase"
RHEA:22396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = glycolaldehyde + guaiacol + H2O + vanillin
RHEA:22396	skos:altLabel	"hybrid peroxidase"
RHEA:22396	skos:altLabel	"VP"
RHEA:22396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"versatile peroxidase"
RHEA:44255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:38202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:58286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + thymine => 5,6-dihydrothymine + NADP(+)
GO:0004903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth hormone receptor activity
REACT:R-DDI-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Dictyostelium discoideum)
REACT:R-DRE-3465448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at DISC (Danio rerio)
RHEA:66155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + noradrenaline <=> CoA + H(+) + N-acetylnoradrenaline
REACT:R-XTR-8874849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBRF binds CREB3 (Xenopus tropicalis)
REACT:R-HSA-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Homo sapiens)
RHEA:45949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]
REACT:R-HSA-111253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Homo sapiens)
REACT:R-SSC-209536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkB is ubiquitinated and degraded (Sus scrofa)
RHEA:33268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+) => 2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+)
GO:0140798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine deiminase activity (H3-R26 specific)
GO:0140798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-R26 arginine deiminase activity
GO:0140798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3-R26 citrullination
GO:0140798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R26 arginine deiminase activity
REACT:R-HSA-2028644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Homo sapiens)
GO:0031689	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A3 adenosine receptor ligand
GO:0031689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A3 adenosine receptor binding
RHEA:51587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]
GO:0102886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-chamigrene synthase activity
RHEA:44594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine
RHEA:39101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + octanedioyl-CoA => 3-oxodecanedioyl-CoA + CoA
REACT:R-DRE-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)
REACT:R-RNO-390252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)
GO:0033782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	24-hydroxycholesterol 7alpha-monooxygenase activity
GO:0033782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-hydroxycholesterol 7alpha-hydroxylase activity
GO:0033782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity
RHEA:13577	skos:prefLabel	"wax-ester hydrolase"
RHEA:13577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a wax ester + H2O = a long chain fatty alcohol + a long-chain fatty acid + H(+)
RHEA:13577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"wax-ester hydrolase"
RHEA:54008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
REACT:R-RNO-5138432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 is phosphorylated by PKC (Rattus norvegicus)
EC:1.14.14.29	skos:altLabel	"25-hydroxycholesterol 7alpha-monooxygenase"
EC:1.14.14.29	skos:altLabel	"27-hydroxycholesterol 7alpha-hydroxylase"
EC:1.14.14.29	skos:altLabel	"25-hydroxycholesterol 7alpha-hydroxylase"
EC:1.14.14.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"25/26-hydroxycholesterol 7alpha-hydroxylase"
EC:1.14.14.29	skos:prefLabel	"25/26-hydroxycholesterol 7alpha-hydroxylase"
EC:1.14.14.29	skos:altLabel	"27-hydroxycholesterol 7-monooxygenase"
RHEA:20165	skos:altLabel	"ornithine esterase"
RHEA:20165	skos:prefLabel	"fusarinine-C ornithinesterase"
RHEA:20165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fusarinine-C ornithinesterase"
RHEA:20165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-acyl-L-ornithine ester = an alcohol + H(+) + N(5)-acyl-L-ornithine
RHEA:44886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => a cardiolipin + H2O
RHEA:70253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol
RHEA:70155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine <=> ADP + H(+) + O-phospho-L-serine
REACT:R-DRE-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Danio rerio)
REACT:R-BTA-9796379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Bos taurus)
REACT:R-BTA-9654521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin dissociates KRAS4B from the plasma membrane (Bos taurus)
RHEA:24465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate
REACT:R-CFA-1974676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta defensin 103 activates TLR1:TLR2 (Canis familiaris)
REACT:R-CFA-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Canis familiaris)
REACT:R-MMU-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Mus musculus)
RHEA:12793	skos:prefLabel	"inositol-hexakisphosphate kinase"
RHEA:12793	skos:altLabel	"IP6K"
RHEA:12793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-hexakisphosphate kinase"
RHEA:12793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP
RHEA:12793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
RHEA:12793	skos:altLabel	"ATP:1D-myo-inositol-hexakisphosphate phosphotransferase"
RHEA:32380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,4S)-limonene-1,2-diol + NAD(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH
REACT:R-HSA-9663354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A5 (prestin) changes conformation in response to depolarization (Homo sapiens)
REACT:R-MMU-3215310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)
REACT:R-SSC-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Sus scrofa)
REACT:R-DME-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Drosophila melanogaster)
REACT:R-DME-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Drosophila melanogaster)
REACT:R-DRE-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Danio rerio)
RHEA:67768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:28912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-lysine(out) => H(+)(in) + L-lysine(in)
RHEA:23063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP <=> a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate
RHEA:53521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-8852167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:Catecholamine binds ARRB1, ARRB2 (Xenopus tropicalis)
REACT:R-SSC-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Sus scrofa)
RHEA:36637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine
RHEA:21444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-hydroxyphenyl)propanoate + NAD(+) = H(+) + NADH + trans-2-coumarate
RHEA:21444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-coumarate reductase"
RHEA:21444	skos:prefLabel	"2-coumarate reductase"
RHEA:21444	skos:altLabel	"melilotate dehydrogenase"
REACT:R-XTR-198813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO dimers reduce DeHA to AscH- (Xenopus tropicalis)
RHEA:39305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z)-eicosatrienoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA
RHEA:69682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-beta-D-glucoside + H2O <=> apigenin + beta-D-glucose
RHEA:35399	skos:prefLabel	"cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) 6'''-O-hydroxycinnamoyltransferase"
RHEA:35399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) 6'''-O-hydroxycinnamoyltransferase"
RHEA:35399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine = beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)
RHEA:30714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-linalool <=> beta-myrcene + H2O
RHEA:68597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => beta-cadinene + diphosphate
REACT:R-HSA-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Homo sapiens)
RHEA:68295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + nonanoyl-CoA <=> CoA + O-nonanoyl-L-seryl-[protein]
REACT:R-BTA-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Bos taurus)
REACT:R-DDI-8873946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD3 deubiquitinates PTEN (Dictyostelium discoideum)
RHEA:71540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + 2 nitrate(out) => H(+)(in) + 2 nitrate(in)
RHEA:69806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + benzoate + H(+) <=> benzoyl-AMP + diphosphate
RHEA:42432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-cis,cis-muconate = maleylacetate
RHEA:35808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-arabinonate => 2,5-dioxopentanoate + H2O
REACT:R-MMU-8851933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates GAB1 (Mus musculus)
GO:0102363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoscopoletin-O-methyltransferase activity
REACT:R-GGA-912685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBP43 binds IFNAR2 and prevents JAK1 interaction (Gallus gallus)
REACT:R-HSA-5632871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC2A10 does not transport Glc from extracellular region to cytosol (Homo sapiens)
REACT:R-HSA-8950347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12A:IL12B translocates from late endosome lumen to extracellular region (Homo sapiens)
RHEA:62843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
RHEA:42271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] <=> 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA
RHEA:21235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine <=> NH4(+) + trans-urocanate
REACT:R-CEL-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Caenorhabditis elegans)
REACT:R-BTA-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Bos taurus)
RHEA:52073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)
REACT:R-CEL-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Caenorhabditis elegans)
REACT:R-DME-8878056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds EP300 (Drosophila melanogaster)
RHEA:21407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + O2 <=> chlorite
GO:0052744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol monophosphate phosphatase activity
REACT:R-RNO-444838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 1 binds relaxin 2 and 3 (Rattus norvegicus)
RHEA:65818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O
GO:0050472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zeatin reductase activity
GO:0050472	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrozeatin:NADP+ oxidoreductase activity
RHEA:71186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine(out) + L-tryptophan(in) <=> L-kynurenine(in) + L-tryptophan(out)
RHEA:68136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetophenone + H(+) + NADPH = (R)-1-phenylethanol + NADP(+)
REACT:R-RNO-1564164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type V degradation by MMP2,9,10 (Rattus norvegicus)
REACT:R-XTR-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Xenopus tropicalis)
REACT:R-DDI-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Dictyostelium discoideum)
RHEA:63791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-2559456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
GO:0047795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity
GO:0047795	skos:prefLabel	"cyclohexane-1,2-diol dehydrogenase"
GO:0047795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1,2-diol dehydrogenase activity
GO:0047795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexane-1,2-diol dehydrogenase"
GO:0047795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + trans-cyclohexane-1,2-diol = 2-hydroxycyclohexan-1-one + H(+) + NADH
REACT:R-DME-5229283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCNs bind lipids (Drosophila melanogaster)
REACT:R-HSA-9683712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3a translocates to the ERGIC (Homo sapiens)
REACT:R-SSC-2428930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Sus scrofa)
RHEA:58513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)
RHEA:33694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate
RHEA:24530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methylglyoxal + NADH => (R)-lactaldehyde + NAD(+)
REACT:R-BTA-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Bos taurus)
REACT:R-BTA-264758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Bos taurus)
GO:0047975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine:phosphate alpha-D-ribosyltransferase activity
GO:0047975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine:phosphate D-ribosyltransferase activity
GO:0047975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine phosphorylase activity
RHEA:65612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:48865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropan-1-amine + FADH2 + O2 => FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine
REACT:R-BTA-5621363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Bos taurus)
REACT:R-DRE-508163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Danio rerio)
REACT:R-CFA-158959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Canis familiaris)
REACT:R-RNO-4551683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOPORS with SUMO1 (Rattus norvegicus)
REACT:R-SPO-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Schizosaccharomyces pombe)
RHEA:15420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arogenate + NADP(+) <=> CO2 + L-tyrosine + NADPH
REACT:R-HSA-9697423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
RHEA:31106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydrofolate + NADP(+) <=> folate + H(+) + NADPH
REACT:R-GGA-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Gallus gallus)
RHEA:53267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5675656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA:EDAR binds EDARADD (Homo sapiens)
RHEA:53110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine
REACT:R-BTA-5686685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Bos taurus)
REACT:R-SPO-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Schizosaccharomyces pombe)
REACT:R-SSC-8849345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Sus scrofa)
GO:0051425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB domain binding
GO:0051425	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PID binding
GO:0051425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphotyrosine-interacting domain binding
REACT:R-RNO-2201341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TRAM (TICAM2) (Rattus norvegicus)
REACT:R-CEL-5423117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates MeK21-histone H4 (Caenorhabditis elegans)
RHEA:57118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
REACT:R-SSC-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Sus scrofa)
RHEA:65375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer <=> CMP + globoside MSGG + H(+)
REACT:R-MMU-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Mus musculus)
REACT:R-HSA-3149539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Homo sapiens)
REACT:R-SSC-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Sus scrofa)
REACT:R-XTR-8874202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the cytosol to the nucleus (Xenopus tropicalis)
REACT:R-CFA-9634834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACHEIs bind ACHE (Canis familiaris)
RHEA:28462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal(in) = pyridoxal(out)
REACT:R-HSA-9631065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Substrate translocates into late endosomal lumen (Homo sapiens)
RHEA:72138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine(out) <=> putrescine(in)
REACT:R-DRE-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Danio rerio)
REACT:R-PFA-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Plasmodium falciparum)
REACT:R-HSA-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Homo sapiens)
RHEA:16557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO2
RHEA:16557	skos:prefLabel	"aminocarboxymuconate-semialdehyde decarboxylase"
RHEA:16557	skos:altLabel	"picolinic acid decarboxylase"
RHEA:16557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminocarboxymuconate-semialdehyde decarboxylase"
GO:0015131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate transmembrane transporter activity
RHEA:68419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-(homo)2aconitate + H2O <=> (2R,3S)-iso(homo)2citrate
REACT:R-MMU-374899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of noradrenaline  at the synapse (Mus musculus)
RHEA:67784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol
REACT:R-SSC-5607740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta phosphorylates CARD9 (Sus scrofa)
REACT:R-HSA-2995376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)
RHEA:61782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-sorbose => keto-L-tagatose
REACT:R-MMU-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Mus musculus)
REACT:R-DRE-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)
REACT:R-MMU-426489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC binds inexactly matching target RNAs (Mus musculus)
REACT:R-HSA-5218854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y420-FYN is phosphorylated on S21 (Homo sapiens)
RHEA:29282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-8 + trimethylamine N-oxide <=> H2O + menaquinone-8 + trimethylamine
RHEA:16907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O
GO:0018129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-oxazoline dehydrogenase activity
REACT:R-HSA-9024386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene (Homo sapiens)
RHEA:19228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]
REACT:R-SSC-200410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Sus scrofa)
GO:0018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutyrate decarboxylase activity
REACT:R-MMU-5419273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of GTP and dissociation of 28S and 39S subunits (Mus musculus)
REACT:R-RNO-2187330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
RHEA:54201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:19843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:16979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopropyl-coenzyme M + CO2 + NADPH => acetoacetate + coenzyme M + NADP(+)
RHEA:40896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine
GO:0047528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity
GO:0047528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxyindole 2,3-dioxygenase activity
RHEA:42956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42956	skos:prefLabel	"tRNA (cytosine(38)-C(5))-methyltransferase"
RHEA:42956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (cytosine(38)-C(5))-methyltransferase"
REACT:R-GGA-6806613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin tetramers bind to form unit length filaments (Gallus gallus)
REACT:R-SSC-8851933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates GAB1 (Sus scrofa)
REACT:R-HSA-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Homo sapiens)
REACT:R-DDI-3159253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAB adenosylates cob(I)alamin (Dictyostelium discoideum)
REACT:R-HSA-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Homo sapiens)
REACT:R-CEL-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Caenorhabditis elegans)
REACT:R-MMU-2176445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD2 (Mus musculus)
RHEA:64262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine => (9Z,12Z)-octadecadienoyl-CoA + glycine
RHEA:50052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out)
REACT:R-MMU-1067651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)
REACT:R-BTA-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Bos taurus)
RHEA:38925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + Na(+)(out) + NAD(+) => a ubiquinone + H(+) + Na(+)(in) + NADH
RHEA:33150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + daunorubicin(in) + H2O <=> ADP + daunorubicin(out) + H(+) + phosphate
RHEA:16420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) <=> H(+) + L-glutamate + NADH
REACT:R-CFA-9023619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Canis familiaris)
RHEA:41608	skos:prefLabel	"trehalose 2-sulfotransferase"
RHEA:41608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)
RHEA:41608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trehalose 2-sulfotransferase"
REACT:R-XTR-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Xenopus tropicalis)
RHEA:19184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-BTA-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Bos taurus)
RHEA:20297	skos:prefLabel	"aryl-acylamidase"
RHEA:20297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aryl-acylamidase"
RHEA:20297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anilide + H2O = a carboxylate + aniline + H(+)
REACT:R-GGA-4090390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates AR with SUMO1 (Gallus gallus)
REACT:R-CFA-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Canis familiaris)
RHEA:15197	skos:prefLabel	"site-specific DNA-methyltransferase (adenine-specific)"
RHEA:15197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"site-specific DNA-methyltransferase (adenine-specific)"
RHEA:15197	skos:altLabel	"restriction-modification system"
RHEA:15197	skos:altLabel	"modification methylase"
RHEA:15197	skos:altLabel	"N-6 adenine-specific DNA methylase"
RHEA:15197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-DRE-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Danio rerio)
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gene dszB-encoded hydrolase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HBPSi desulfinase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HPBS desulfinase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DszB
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxybiphenyl-2-sulfinate desulfinase activity
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dibenzothiophene desulfurization enzyme B
GO:0018740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity
REACT:R-SSC-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Sus scrofa)
RHEA:12633	skos:altLabel	"benzoate hydroxylase"
RHEA:12633	skos:altLabel	"benzoic hydroxylase"
RHEA:12633	skos:prefLabel	"benzoate 1,2-dioxygenase"
RHEA:12633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzoate 1,2-dioxygenase"
RHEA:12633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + H(+) + NADH + O2 = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)
RHEA:26318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate
RHEA:17809	skos:altLabel	"S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase"
RHEA:17809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-protoporphyrin IX + S-adenosyl-L-methionine = Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine
RHEA:17809	skos:altLabel	"magnesium-protoporphyrin O-methyltransferase"
RHEA:17809	skos:altLabel	"S-adenosylmethionine-magnesium protoporphyrin methyltransferase"
RHEA:17809	skos:prefLabel	"magnesium protoporphyrin IX methyltransferase"
RHEA:17809	skos:altLabel	"(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase"
RHEA:17809	skos:altLabel	"S-adenosylmethioninemagnesium protoporphyrin methyltransferase"
RHEA:17809	skos:altLabel	"Mg-protoporphyrin IX methyltransferase"
RHEA:17809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"magnesium protoporphyrin IX methyltransferase"
RHEA:17809	skos:altLabel	"S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase"
REACT:R-MMU-2162019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to EXA4 by ALOX15 (Mus musculus)
RHEA:69801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophan + tRNA(Trp) => D-tryptophanyl-tRNA(Trp) + H2O
REACT:R-DME-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Drosophila melanogaster)
RHEA:58159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + 4 Na(+)(in) <=> ADP + H(+) + 4 Na(+)(out) + phosphate
REACT:R-HSA-388855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin-releasing hormone receptor binds PRH (Homo sapiens)
RHEA:38681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + sphinganine(out) => ATP + H2O + sphinganine(in)
RHEA:26330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + L-lysine => (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate
REACT:R-HSA-416562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGAP binds Plexin-B1 (Homo sapiens)
RHEA:50269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
GO:0005274	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	allantoin/allantoate transporter
GO:0005274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoin:proton symporter activity
GO:0005274	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	allantoin uptake transmembrane transporter activity
GO:0005274	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	allantoin permease activity
RHEA:43266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA
REACT:R-RNO-390304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoASH (Rattus norvegicus)
REACT:R-XTR-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Xenopus tropicalis)
REACT:R-SSC-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Sus scrofa)
REACT:R-RNO-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Rattus norvegicus)
REACT:R-DRE-9033499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Danio rerio)
REACT:R-MMU-193455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Mus musculus)
RHEA:45009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(octadecanoyl)-sphinganine => octadecanoate + sphinganine
REACT:R-CFA-9706323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA2 (Canis familiaris)
REACT:R-DRE-74715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of insulin receptor (Danio rerio)
REACT:R-CFA-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Canis familiaris)
REACT:R-DME-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Drosophila melanogaster)
RHEA:42311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-XTR-77331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Xenopus tropicalis)
REACT:R-DRE-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Danio rerio)
REACT:R-RNO-975097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
REACT:R-HSA-4420206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SRC-1 (Homo sapiens)
REACT:R-HSA-139952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 processing in the DISC (Homo sapiens)
REACT:R-SSC-5218841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)
REACT:R-DRE-5694109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer hydrolyses TAG to DAG and FA (Danio rerio)
REACT:R-HSA-5218818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Homo sapiens)
REACT:R-HSA-198609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates TSC2, inhibiting it (Homo sapiens)
REACT:R-HSA-9619803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S516-ARHGEF7 activates RAC1 (Homo sapiens)
REACT:R-DRE-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Danio rerio)
REACT:R-HSA-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Homo sapiens)
REACT:R-XTR-166795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Classical C3 convertase (C4b:C2a complex) (Xenopus tropicalis)
RHEA:54565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O => a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)
REACT:R-XTR-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)
RHEA:29052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + H2 + menaquinone-8 => 2 H(+)(out) + menaquinol-8
REACT:R-BTA-183055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to EGFR (Bos taurus)
REACT:R-CFA-8983876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds IL12RB2:IL12RB2 (Canis familiaris)
REACT:R-HSA-8956639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds YAP1 (Homo sapiens)
REACT:R-BTA-166271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Bos taurus)
REACT:R-DDI-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Dictyostelium discoideum)
REACT:R-BTA-450325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-FOS activation by phospho ERK1/2 (Bos taurus)
REACT:R-CFA-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Canis familiaris)
RHEA:31168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanoyl-CoA + NAD(+) => 3-oxotetradecanoyl-CoA + H(+) + NADH
RHEA:14030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + selenite => AH2 + selenate
REACT:R-DME-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Drosophila melanogaster)
REACT:R-HSA-9027273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Homo sapiens)
REACT:R-HSA-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Homo sapiens)
RHEA:50831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate
REACT:R-CEL-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Caenorhabditis elegans)
GO:0004325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferrochelatase activity
GO:0004325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoheme ferro-lyase activity
GO:0004325	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	iron chelatase activity
GO:0004325	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	heme synthetase activity
GO:0004325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoheme ferro-lyase (protoporphyrin-forming)
GO:0004325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoheme ferrolyase activity
GO:0004325	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	heme synthase activity
GO:0004325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferro-protoporphyrin chelatase activity
REACT:R-DRE-5624132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Danio rerio)
REACT:R-SPO-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Schizosaccharomyces pombe)
RHEA:10114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L,L-cystathionine => L-homocysteine + L-serine
RHEA:70374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + decanoyl-CoA <=> CoA + H(+) + N-decanoyl-3-oxosphinganine
REACT:R-DME-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Drosophila melanogaster)
RHEA:62789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 fonsecin B + H(+) + NADPH + O2 => aurasperone B + 2 H2O + NADP(+)
RHEA:20046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H2O + NAD(+) => 2 H(+) + malonate + NADH
REACT:R-HSA-71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer reduces PYR to LACT (Homo sapiens)
REACT:R-MMU-201630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Acinus (Mus musculus)
GO:0071576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydrodictyopterin binding
GO:0071576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-tetrahydrobiopterin
GO:0071576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DH4 binding
RHEA:72979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	didemethylasterriquinone D + dimethylallyl diphosphate = asterriquinone C1 + diphosphate
REACT:R-RNO-4332363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation and activation of CAMK2 (Rattus norvegicus)
REACT:R-HSA-1791155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of EDEM (Homo sapiens)
GO:0015153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnose(in) = L-rhamnose(out)
GO:0015153	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATPase-coupled rhamnose transmembrane transporter activity
GO:0015153	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP-dependent rhamnose transmembrane transporter activity
GO:0015153	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	rhamnose-transporting ATPase activity
GO:0015153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnose transmembrane transporter activity
REACT:R-CFA-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Canis familiaris)
REACT:R-RNO-1655831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 translocates to the nucleus (Rattus norvegicus)
REACT:R-RNO-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Rattus norvegicus)
RHEA:36114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A1 + S-adenosyl-L-methionine <=> O-methyl gibberellin A1 + S-adenosyl-L-homocysteine
RHEA:32029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-alpha-cuprenene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:10754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate
RHEA:34260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-larreatricin + AH2 + O2 => (+)-3'-hydroxylarreatricin + A + H2O
REACT:R-DME-1306969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)
REACT:R-MTU-879331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-6-phosphate is converted to inositol-1-phosphate (Mycobacterium tuberculosis)
RHEA:44056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA
REACT:R-RNO-5687640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Rattus norvegicus)
RHEA:23923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate
REACT:R-SPO-163664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binds to gamma subunit of AMP kinase heterotrimer (Schizosaccharomyces pombe)
REACT:R-CEL-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Caenorhabditis elegans)
REACT:R-CFA-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Canis familiaris)
RHEA:64302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanal + L-alanine => 3-phenylpropylamine + pyruvate
REACT:R-CFA-6790487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 ubiquitinates SUMOylated XPC (Canis familiaris)
REACT:R-DDI-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Dictyostelium discoideum)
RHEA:14937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:12344	skos:prefLabel	"glutamyl-tRNA reductase"
RHEA:12344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamyl-tRNA reductase"
RHEA:12344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH
RHEA:39399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA = (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O
RHEA:55047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-tetradecadienoyl-CoA + H2O <=> (3E,5Z)-tetradecadienoate + CoA + H(+)
GO:0050404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoxylose-zeatin xylosyltransferase activity
GO:0050404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zeatin O-xylosyltransferase activity
GO:0050404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zeatin O-beta-D-xylosyltransferase activity
GO:0050404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zeatin O-b-D-xylosyltransferase activity
GO:0050404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity
REACT:R-CFA-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Canis familiaris)
RHEA:40505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine
RHEA:52325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-arginine + 4 O2 + 3 reduced [flavodoxin] => 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]
REACT:R-BTA-5324632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Bos taurus)
REACT:R-GGA-909729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JAK kinases (Gallus gallus)
REACT:R-BTA-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Bos taurus)
REACT:R-CEL-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Caenorhabditis elegans)
RHEA:53362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NADP(+)
GO:0047090	skos:prefLabel	"benzoyl-CoA 3-monooxygenase"
GO:0047090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA 3-hydroxylase activity
GO:0047090	skos:altLabel	"benzoyl-CoA 3-hydroxylase"
GO:0047090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA 3-monooxygenase activity
GO:0047090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + H(+) + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP(+)
GO:0047090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzoyl-CoA 3-monooxygenase"
GO:0047090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)
REACT:R-GGA-4755478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates IKBKE with SUMO1 (Gallus gallus)
REACT:R-SSC-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Sus scrofa)
REACT:R-SSC-6814409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates PDCL (Sus scrofa)
REACT:R-CFA-5694109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer hydrolyses TAG to DAG and FA (Canis familiaris)
REACT:R-MMU-110250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenoadenine by MPG glycosylase (Mus musculus)
REACT:R-XTR-5362551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Xenopus tropicalis)
REACT:R-GGA-1980044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 binds JAG2 (Gallus gallus)
GO:0102844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming)
REACT:R-GGA-5687183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKDC phosphorylates DCLRE1C at DNA DSBs (Gallus gallus)
RHEA:66598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dopamine => O2 + 2 tyramine
RHEA:23900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin
RHEA:57836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + thermospermine = 3-aminopropanal + H2O2 + spermidine
REACT:R-CFA-391935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP1 receptor can bind PGD2 (Canis familiaris)
REACT:R-HSA-5389849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA (Homo sapiens)
REACT:R-DDI-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Dictyostelium discoideum)
REACT:R-CFA-177479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Axonal transport of NGF:Trk complexes (Canis familiaris)
RHEA:72457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + 3 H(+)(in) => fumarate(out) + 3 H(+)(out)
REACT:R-DRE-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Danio rerio)
REACT:R-DRE-8874685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds MET (Danio rerio)
GO:0004532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Homo sapiens)
GO:0004532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exoribonuclease activity
GO:0044715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGDP phosphatase activity
GO:0044715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate
REACT:R-XTR-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Xenopus tropicalis)
REACT:R-DDI-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Dictyostelium discoideum)
RHEA:18143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxycyclohexan-1-one + H(+) + NADH => NAD(+) + trans-cyclohexane-1,2-diol
REACT:R-MMU-3229181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALM1:Ca2+ binds CNG channel (Mus musculus)
RHEA:68103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + xylitol <=> H(+) + L-xylulose + NADH
RHEA:17060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]
RHEA:62839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine
REACT:R-HSA-2002428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen N-propeptides (Homo sapiens)
RHEA:20217	skos:altLabel	"trimethylamine-N-oxide formaldehyde-lyase"
RHEA:20217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde
RHEA:20217	skos:prefLabel	"trimethylamine-oxide aldolase"
RHEA:20217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trimethylamine-oxide aldolase"
RHEA:48993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,7-trimethylurate + H(+) + NADH + O2 => 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)
REACT:R-GGA-9702354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCA antibodies (Gallus gallus)
RHEA:19522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + phosphate => acetyl phosphate + CoA
REACT:R-MMU-9021050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 oligomer binds ESRs (Mus musculus)
RHEA:42930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine
REACT:R-DRE-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Danio rerio)
REACT:R-XTR-2730862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of LYN kinase (Xenopus tropicalis)
GO:0033948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-(2,1)-linkage-specific fructan-beta-fructosidase activity
GO:0033948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-FEH II
GO:0033948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-(2,1)-fructan exohydrolase activity
GO:0033948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-FEH w1
GO:0033948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-fructan exohydrolase activity
GO:0033948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructan beta-(2,1)-fructosidase activity
GO:0033948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-FEH w2
GO:0033948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-(2,1)-D-fructan fructohydrolase activity
REACT:R-CEL-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Caenorhabditis elegans)
REACT:R-SPO-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Schizosaccharomyces pombe)
REACT:R-SSC-9013022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GAPs stimulate RHOB GTPase activity (Sus scrofa)
RHEA:32015	skos:prefLabel	"(-)-delta-cadinene synthase"
RHEA:32015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-delta-cadinene synthase"
RHEA:32015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate
RHEA:20597	skos:prefLabel	"cystine reductase"
RHEA:20597	skos:altLabel	"NADH-dependent cystine reductase"
RHEA:20597	skos:altLabel	"cystine reductase (NADH)"
RHEA:20597	skos:altLabel	"NADH:L-cystine oxidoreductase"
RHEA:20597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-cysteine + NAD(+) = H(+) + L-cystine + NADH
RHEA:20597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cystine reductase"
RHEA:49629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine => 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine
REACT:R-MMU-8959462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Mus musculus)
RHEA:40219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonyl-CoA = CoA + H(+) + malonate
GO:0047567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyleneoxindole reductase activity
GO:0047567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyloxindole:NADP+ oxidoreductase activity
GO:0047567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity
REACT:R-DRE-77609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of APOBEC-1 to form editosome (Danio rerio)
REACT:R-DDI-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Dictyostelium discoideum)
RHEA:34375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanamide + H2O = 4-guanidinobutanoate + NH4(+)
RHEA:64145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-methionine => (9Z)-octadecenoate + L-methionine
REACT:R-BTA-1296024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in neuroendocrine cells (Bos taurus)
EC:3.2.1.6	skos:altLabel	"laminarinase"
EC:3.2.1.6	skos:altLabel	"endo-1,4-beta-glucanase"
EC:3.2.1.6	skos:altLabel	"endo-1,3-beta-glucanase"
EC:3.2.1.6	skos:prefLabel	"endo-1,3(4)-beta-glucanase"
EC:3.2.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endo-1,3(4)-beta-glucanase"
REACT:R-CFA-9645501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Canis familiaris)
REACT:R-XTR-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Xenopus tropicalis)
RHEA:41084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:23047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-tyrosine <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O
RHEA:58963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H2O + O2 <=> benzoate + H(+) + H2O2
REACT:R-HSA-9617207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene (Homo sapiens)
REACT:R-CFA-380272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plk1-mediated phosphorylation of Nlp (Canis familiaris)
GO:0102575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-dodecanoyl-ACP hydrolase activity
GO:0102681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoamylase (maltodextrin-releasing) activity
RHEA:50384	skos:altLabel	"12-dehydrotetracycline dehydrogenase"
RHEA:50384	skos:altLabel	"dehydrooxytetracycline dehydrogenase"
RHEA:50384	skos:altLabel	"12-dehydrotetracycline reductase"
RHEA:50384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline = 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:50384	skos:prefLabel	"5a,11a-dehydrotetracycline reductase"
RHEA:50384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:50384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5a,11a-dehydrotetracycline reductase"
REACT:R-GGA-353273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by Pol zeta complex (Gallus gallus)
REACT:R-HSA-5632804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer does not transport Glc from extracellular region to cytosol (Homo sapiens)
RHEA:26193	skos:altLabel	"malate thiokinase"
RHEA:26193	skos:prefLabel	"malate--CoA ligase"
RHEA:26193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
RHEA:26193	skos:altLabel	"malyl-CoA synthetase"
RHEA:26193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malate--CoA ligase"
RHEA:34543	skos:prefLabel	"N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-alpha-N-acetylgalactosaminyltransferase"
RHEA:34543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-alpha-N-acetylgalactosaminyltransferase"
RHEA:34543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP
REACT:R-XTR-5654633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS bind to PPTN11 (Xenopus tropicalis)
RHEA:64538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base
REACT:R-RNO-1250348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by ERBB4 homodimers (Rattus norvegicus)
RHEA:52849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine => 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-5423637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR dimers reduce AFBDHO to AFBDOH (Canis familiaris)
RHEA:11042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O => D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
EC:3.4.24.33	skos:altLabel	"endoproteinase Asp-N"
EC:3.4.24.33	skos:prefLabel	"peptidyl-Asp metalloendopeptidase"
EC:3.4.24.33	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidyl-Asp metalloendopeptidase"
RHEA:20270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate => 2 5-dehydro-4-deoxy-D-glucuronate
REACT:R-SSC-391937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP/CysLT receptor can bind cysteinyl leukotrienes (Sus scrofa)
REACT:R-CFA-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Canis familiaris)
REACT:R-SPO-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Schizosaccharomyces pombe)
RHEA:54926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP] => (7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP]
REACT:R-BTA-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Bos taurus)
RHEA:70109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + penilactone D => (S)-5-carboxymethyl-tetronate + o-quinone methide
RHEA:42633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine
REACT:R-CFA-8867754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
GO:0018771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity
GO:0018771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase activity
GO:0018771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity
REACT:R-CFA-168947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand binds to TLR10 (Canis familiaris)
REACT:R-HSA-9022934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAD1 gene expression is stimulated by MECP2 (Homo sapiens)
RHEA:13686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH
REACT:R-XTR-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Xenopus tropicalis)
RHEA:21561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol => 1,4-dithiothreitol + 2,3-epoxyphylloquinone
REACT:R-HSA-9613530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKAA2 phosphorylates PLINs (Homo sapiens)
RHEA:34818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 NADP(+) + tetrahydrocurcumin <=> curcumin + 2 H(+) + 2 NADPH
RHEA:12537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arogenate => CO2 + H2O + L-phenylalanine
RHEA:57773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite
REACT:R-MMU-265645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Influx through Voltage-gated Calcium Channels (Mus musculus)
RHEA:48550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O
REACT:R-HSA-5250938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Homo sapiens)
RHEA:30317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + formaldehyde + H2O + NAD(+) => 1,7-dimethylxanthine + H(+) + NADH + O2
REACT:R-BTA-158942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Bos taurus)
RHEA:29927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate(in) + Na(+)(in) = (R)-pantothenate(out) + Na(+)(out)
REACT:R-MMU-140783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Mus musculus)
GO:0016898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a cytochrome as acceptor"
GO:0016898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
GO:0016898	skos:prefLabel	"With a cytochrome as acceptor"
RHEA:31657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine => 4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O
REACT:R-BTA-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Bos taurus)
REACT:R-MMU-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Mus musculus)
RHEA:41990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-pregnane-3,20-dione + H(+) + NADH => 3beta-hydroxy-5alpha-pregnane-20-one + NAD(+)
REACT:R-HSA-9707645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 gene produces HMOX1 dimer (Homo sapiens)
REACT:R-DRE-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Danio rerio)
REACT:R-MMU-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Mus musculus)
GO:0080066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity
RHEA:34093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + NH4(+) + phosphate => (5R)-5-phosphooxy-L-lysine + H2O
RHEA:53141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-936563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of DDX58 (Caenorhabditis elegans)
RHEA:14875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-acetaldehyde + NADH => indole-3-ethanol + NAD(+)
REACT:R-RNO-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Rattus norvegicus)
RHEA:64906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + 2 H(+) + 2 phosphate => GTP + 2 H2O
REACT:R-CFA-5654677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR2 (Canis familiaris)
RHEA:11591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + isoquinoline <=> AH2 + isoquinolin-1(2H)-one
REACT:R-CFA-9757951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
REACT:R-DRE-8862700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMKLR1 binds Resolvin E1 (Danio rerio)
REACT:R-HSA-5607002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor VIIIa (Homo sapiens)
RHEA:66199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + tryptamine <=> CoA + H(+) + N-acetyltryptamine
RHEA:58838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-DDI-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Dictyostelium discoideum)
REACT:R-XTR-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Xenopus tropicalis)
REACT:R-BTA-2396599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)
REACT:R-MMU-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Mus musculus)
REACT:R-SSC-8936608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)
RHEA:16063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycerol 3-phosphocholine
RHEA:43366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP => L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose
REACT:R-CFA-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Canis familiaris)
RHEA:22051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate
REACT:R-RNO-5591052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROCR binds Protein C (Rattus norvegicus)
REACT:R-MMU-1606288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Mus musculus)
RHEA:62429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => 3,4-dihydroxybenzaldehyde + acetyl-CoA
REACT:R-SCE-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)
RHEA:45066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine + hexadecanoate => H2O + N-hexadecanoylethanolamine
RHEA:29832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ni(2+)(in) => Ni(2+)(out)
REACT:R-XTR-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-CFA-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Canis familiaris)
REACT:R-GGA-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Gallus gallus)
REACT:R-HSA-391871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of NCAM1 bound Fyn (Homo sapiens)
RHEA:45860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-DRE-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Danio rerio)
RHEA:36333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate => ATP + dimethylallyl diphosphate
RHEA:70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-galactosamine
RHEA:53503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
REACT:R-DRE-5695964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD14B hydrolyses PNPB (Danio rerio)
REACT:R-HSA-2220979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)
EC:1.1.1.81	skos:prefLabel	"hydroxypyruvate reductase"
EC:1.1.1.81	skos:altLabel	"D-glycerate dehydrogenase"
EC:1.1.1.81	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxypyruvate reductase"
RHEA:39424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O
REACT:R-MMU-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Mus musculus)
GO:0042614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD27L binding
GO:0042614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CD27 receptor activity
GO:0042614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD70 receptor binding
REACT:R-HSA-376364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp8 associated secretory vesicle to plasma membrane transport (Homo sapiens)
RHEA:11906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dihydroxypteridine + NH4(+) => 2-amino-4-hydroxypteridine + H(+) + H2O
RHEA:63075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + orcinol
GO:0018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity
RHEA:23449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP => CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate
REACT:R-DDI-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Dictyostelium discoideum)
REACT:R-DME-209355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monomeric PGN binds to PGRP-LCx at the plasma membrane (Drosophila melanogaster)
RHEA:25522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + O-acylpseudotropine => an acyl-CoA + pseudotropine
RHEA:47620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethylhexyl sulfate + 2-oxoglutarate + O2 = 2-ethylhexanal + CO2 + H(+) + succinate + sulfate
REACT:R-CEL-1169397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ISG15 by UBA7 E1 ligase (Caenorhabditis elegans)
EC:5.6.1.1	skos:prefLabel	"microtubule-severing ATPase"
EC:5.6.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"microtubule-severing ATPase"
EC:5.6.1.1	skos:altLabel	"katanin"
RHEA:55243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)
REACT:R-MMU-5661217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds zinc (Mus musculus)
RHEA:11764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylguanidine = methylamine + urea
RHEA:11764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylguanidinase"
RHEA:11764	skos:prefLabel	"methylguanidinase"
GO:0050642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2alpha-hydroxytaxane 2-O-benzoyltransferase activity
GO:0050642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-alpha-hydroxytaxane 2-O-benzoyltransferase activity
GO:0050642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity
GO:0050642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity
GO:0050642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity
GO:0050642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2a-hydroxytaxane 2-O-benzoyltransferase activity
GO:0050642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity
RHEA:43788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Met) cytidine acetyltransferase"
RHEA:43788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate
RHEA:43788	skos:prefLabel	"tRNA(Met) cytidine acetyltransferase"
REACT:R-CFA-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Canis familiaris)
RHEA:10717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate => 1D-myo-inositol 3-phosphate
REACT:R-DRE-5649764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Danio rerio)
REACT:R-DRE-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Danio rerio)
RHEA:36196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)
RHEA:29941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + phosphate(out) => H(+)(in) + phosphate(in)
REACT:R-HSA-171059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Homo sapiens)
RHEA:70092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + o-quinone methide => hydroxyclavatol ethyl ether
RHEA:45854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(II)-factor IV + S-adenosyl-L-homocysteine => Co(II)-factor III + H(+) + S-adenosyl-L-methionine
RHEA:70007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + ATP + H(+) = 2-aminobenzoyl-AMP + diphosphate
REACT:R-MMU-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Mus musculus)
REACT:R-RNO-390886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH4 binds Hist (Rattus norvegicus)
RHEA:31050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonate semialdehyde + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA
REACT:R-MMU-9647631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds PIPs (Mus musculus)
REACT:R-CEL-175987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from AdoMet to PY (Caenorhabditis elegans)
RHEA:20142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-alkyl-L-cysteine S-oxide => 2-aminoprop-2-enoate + an S-alkyl sulfenate
RHEA:52089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
RHEA:59911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanal + NADP(+) <=> 2 H(+) + hexanoate + NADPH
REACT:R-HSA-9727292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA6 is translated to protein 6 (Homo sapiens)
REACT:R-MMU-451900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RB binds JAK1 (Mus musculus)
RHEA:10424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-benzoylglycine = benzoate + glycine
RHEA:10424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hippurate hydrolase"
RHEA:10424	skos:altLabel	"Hippuricase"
RHEA:10424	skos:altLabel	"Benzoylglycine amidohydrolase"
RHEA:10424	skos:prefLabel	"hippurate hydrolase"
REACT:R-CFA-164423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PhosphoChREBP (Thr 666)  is exported to cytosol (Canis familiaris)
RHEA:56794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]
REACT:R-CEL-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Caenorhabditis elegans)
REACT:R-MMU-167408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The high affinity receptor complex binds to G-protein (Mus musculus)
GO:0004439	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	triphosphoinositide phosphatase activity
GO:0004439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 5-phosphatase activity
GO:0004439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PtdIns(4,5)P(2) 5-phosphatase activity
GO:0004439	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylinositol 4,5-bisphosphate phosphatase activity
GO:0004439	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylinositol-bisphosphatase activity
GO:0004439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PtdIns(4,5)P2 5-phosphatase activity
GO:0004439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity
GO:0004439	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	triphosphoinositide phosphomonoesterase activity
REACT:R-CFA-5684862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Canis familiaris)
REACT:R-HSA-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Homo sapiens)
RHEA:32075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate
RHEA:32075	skos:altLabel	"labda-7,13E-dien-15-ol synthase"
RHEA:32075	skos:prefLabel	"(13E)-labda-7,13-dien-15-ol synthase"
RHEA:32075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(13E)-labda-7,13-dien-15-ol synthase"
REACT:R-RNO-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
REACT:R-DRE-5638006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3 hydrolyzes GTP (Danio rerio)
REACT:R-HSA-8932275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Homo sapiens)
REACT:R-CFA-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
REACT:R-RNO-388809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTLA-4 binds B7-1/B7-2 (Rattus norvegicus)
REACT:R-SSC-193070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPREG to DHA (Sus scrofa)
REACT:R-BTA-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Bos taurus)
REACT:R-BTA-5692779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S182 MAPKAPK5 phosphorylates FOXO1 (Bos taurus)
REACT:R-CFA-199299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO transcription factors (Canis familiaris)
RHEA:35026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone O-beta-D-glucopyranoside(out) <=> hydroquinone O-beta-D-glucopyranoside(in)
REACT:R-DRE-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Danio rerio)
REACT:R-CFA-8950766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA dimerizes (Canis familiaris)
REACT:R-BTA-5610737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH bind and ubiquitnate GLI1 (Bos taurus)
REACT:R-SCE-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Saccharomyces cerevisiae)
RHEA:12379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-fuculose <=> ADP + H(+) + L-fuculose 1-phosphate
REACT:R-XTR-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Xenopus tropicalis)
RHEA:59928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythritol + NADP(+) = D-erythrose + H(+) + NADPH
RHEA:36839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-RNO-5654591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
REACT:R-HSA-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Homo sapiens)
RHEA:27527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesol + diphosphate
RHEA:21924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH
REACT:R-SSC-8855375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dissociates from CSK (Sus scrofa)
RHEA:35788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	paromamine + UDP-alpha-D-kanosamine => H(+) + kanamycin C + UDP
REACT:R-RNO-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)
RHEA:18230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + NAD(+) => glyoxylate + H(+) + NADH
RHEA:14814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-aminohexano-6-lactam => D-2-aminohexano-6-lactam
REACT:R-RNO-1855180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Rattus norvegicus)
GO:0098605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeHCys and Ser are dehydrated into SeCysta by CBS (Homo sapiens)
GO:0098605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenocystathionine beta-synthase activity
REACT:R-SSC-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Sus scrofa)
RHEA:60349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
REACT:R-DRE-173636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of classic pathway C5 convertase (Danio rerio)
REACT:R-MMU-5362500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Mus musculus)
RHEA:17144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + oxaloacetate <=> glyoxylate + L-aspartate
REACT:R-HSA-73815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)
RHEA:66347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate
RHEA:13319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + CO2 => (2R,3R)-tartrate + H(+)
RHEA:31585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-dAMP + diphosphate + H(+) => 2-oxo-dATP + H2O
REACT:R-HSA-392206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i) inhibits adenylate cyclase (Homo sapiens)
REACT:R-DME-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Drosophila melanogaster)
GO:0072532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity
RHEA:29973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine(out) + H(+)(out) => 2'-deoxyinosine(in) + H(+)(in)
REACT:R-RNO-1358790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates ERBB3 (Rattus norvegicus)
REACT:R-XTR-8982645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRKs bind ADRB2:Catecholamine (Xenopus tropicalis)
REACT:R-HSA-448661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)
RHEA:35752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + kanosamine => ADP + D-kanosamine 6-phosphate + H(+)
REACT:R-GGA-141026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor Va to factor Vi intermediate form (Gallus gallus)
REACT:R-DDI-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Dictyostelium discoideum)
REACT:R-CFA-177931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)
GO:0050316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:(d)NMP phosphotransferase activity
GO:0050316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T2-induced deoxynucleotide kinase activity
REACT:R-GGA-349444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of COP1 at Ser-387  by ATM (Gallus gallus)
RHEA:47513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isocholate + NAD(+)
REACT:R-MMU-192137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
REACT:R-BTA-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Bos taurus)
REACT:R-HSA-372693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
REACT:R-RNO-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Rattus norvegicus)
RHEA:14389	skos:altLabel	"beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase"
RHEA:14389	skos:altLabel	"GnTE"
RHEA:14389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase"
RHEA:14389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:14389	skos:prefLabel	"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase"
RHEA:14389	skos:altLabel	"poly-N-acetyllactosamine extension enzyme"
REACT:R-BTA-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Bos taurus)
RHEA:39632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)
RHEA:53139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH
GO:0016964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2 macroglobulin receptor activity
RHEA:54047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> 7-epi-alpha-eudesmol + diphosphate
REACT:R-DRE-1482695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Danio rerio)
REACT:R-MMU-388828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PD-1 binds B7DC and B7H1 (Mus musculus)
RHEA:54212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine
RHEA:41837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanoyl-[ACP] + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-CEL-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Caenorhabditis elegans)
RHEA:38508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate
REACT:R-CFA-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Canis familiaris)
REACT:R-GGA-917814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Gallus gallus)
RHEA:52277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + vanillate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate
RHEA:18621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2S)-flavan-4-one + O2 = a (2R,3R)-dihydroflavonol + CO2 + succinate
RHEA:18621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavanone 3-dioxygenase"
RHEA:18621	skos:altLabel	"flavanone synthase I"
RHEA:18621	skos:prefLabel	"flavanone 3-dioxygenase"
RHEA:18621	skos:altLabel	"naringenin 3-dioxygenase"
RHEA:18621	skos:altLabel	"naringenin 3-hydroxylase"
RHEA:18621	skos:altLabel	"flavanone 3-hydroxylase"
RHEA:18621	skos:altLabel	"flavanone 3beta-hydroxylase"
RHEA:18621	skos:altLabel	"(2S)-flavanone 3-hydroxylase"
RHEA:20686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NAD(+) => H(+) + keto-D-tagatose + NADH
RHEA:66668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] = 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Sus scrofa)
RHEA:69547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptidine <=> 6-O-adenylylstreptidine + diphosphate
RHEA:41855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + octanoyl-[ACP] <=> 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-CFA-9629216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Canis familiaris)
RHEA:36647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine
RHEA:54758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide => deamido-NAD(+) + hydrogencarbonate
RHEA:60964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP
GO:0018795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity
REACT:R-SSC-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Sus scrofa)
REACT:R-CEL-1606602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Caenorhabditis elegans)
REACT:R-CFA-9609743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Canis familiaris)
REACT:R-DME-2730959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN7:OSTM1 exchanges Cl- for H+ (Drosophila melanogaster)
REACT:R-RNO-4085033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Rattus norvegicus)
REACT:R-XTR-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)
RHEA:39445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH
RHEA:54484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine
RHEA:47002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DRE-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Danio rerio)
RHEA:60927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + L-lysyl-[protein] + succinate
RHEA:24573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + sucrose => [(1->4)-alpha-D-glucosyl](n+1) + D-fructose
REACT:R-CFA-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Canis familiaris)
RHEA:38460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA => 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA
REACT:R-XTR-622415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 binds NEMO (Xenopus tropicalis)
REACT:R-MMU-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Mus musculus)
RHEA:17319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a + diphosphate => chlorophyllide a + H(+) + phytyl diphosphate
REACT:R-BTA-164617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of Extended Telomeric Chromosome End (Bos taurus)
REACT:R-CFA-873919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Canis familiaris)
REACT:R-BTA-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Bos taurus)
EC:2.6.99.1	skos:prefLabel	"dATP(dGTP)--DNA purinetransferase"
EC:2.6.99.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dATP(dGTP)--DNA purinetransferase"
REACT:R-CEL-1592297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full activation of MMP1 (Caenorhabditis elegans)
REACT:R-HSA-8950426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of lymphocyte cytosolic protein 1 (Homo sapiens)
REACT:R-SSC-70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer oxidises LACT to PYR (Sus scrofa)
REACT:R-XTR-432164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Xenopus tropicalis)
RHEA:42492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 = 3'-N-debenzoyltaxol + A + H2O
REACT:R-CFA-6807875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)
RHEA:67210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methoxytryptamine + acetate => H2O + melatonin
REACT:R-GGA-9018572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates NOTCH3 (Gallus gallus)
RHEA:10221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tyrosine + tRNA(Tyr) => AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)
REACT:R-SSC-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Sus scrofa)
REACT:R-GGA-5685156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2 (Gallus gallus)
RHEA:10790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-2-dehydro-D-gluconate + ADP + H(+) => 2-dehydro-D-gluconate + ATP
REACT:R-BTA-209821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of N-acetyl-5-HT to form melatonin (Bos taurus)
REACT:R-CEL-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Caenorhabditis elegans)
RHEA:20368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
RHEA:25434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-ribofuranose => beta-D-ribopyranose
REACT:R-MMU-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Mus musculus)
RHEA:53037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-MMU-2046096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Mus musculus)
REACT:R-MMU-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Mus musculus)
RHEA:21037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA => acetoacetyl-CoA + CoA
REACT:R-XTR-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Xenopus tropicalis)
RHEA:65310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP] => an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP]
REACT:R-BTA-5669097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA trimer binds TNFRSF1A,1B,14 (Bos taurus)
REACT:R-BTA-2423785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR:atREs binds apoE and HSPG (Bos taurus)
REACT:R-SPO-1482571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)
RHEA:70832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-leucine(out) + Na(+)(out) => L-arginine(out) + L-leucine(in) + Na(+)(in)
RHEA:41930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H(+) + NADPH
GO:0102851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-16:0-phosphatidylglycerol desaturase activity
REACT:R-XTR-8855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR binds DAB1 (Xenopus tropicalis)
RHEA:39114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH
RHEA:25810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal + H2O2 + putrescine => H2O + O2 + spermidine
REACT:R-RNO-9611277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds P2RY12 antagonists (Rattus norvegicus)
REACT:R-XTR-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Xenopus tropicalis)
RHEA:37922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
GO:0030023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular matrix constituent conferring elasticity
GO:0030023	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core matrisome
GO:0030023	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core extracellular matrix
GO:0030023	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	elastin
RHEA:43786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine
REACT:R-HSA-374681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 and NCAM1 engaged in cis-interaction (Homo sapiens)
REACT:R-RNO-114275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BAX at the mitochondrial membrane (Rattus norvegicus)
GO:0015230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin adenine dinucleotide carrier activity
GO:0015230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD transmembrane transporter activity
GO:0015230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavin-adenine dinucleotide transmembrane transporter activity
GO:0015230	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	FAD transporter activity
GO:0015230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD carrier activity
GO:0015230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin-adenine dinucleotide carrier activity
GO:0015230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavin adenine dinucleotide transmembrane transporter activity
REACT:R-HSA-6807224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-BGLAP to BGLAP (Homo sapiens)
RHEA:48339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)
RHEA:29158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) <=> 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)
REACT:R-RNO-419389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA-binding receptors bind LPA (Rattus norvegicus)
REACT:R-CFA-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)
GO:0050283	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine-O-sulfate ammonia-lyase (pyruvate-forming)
GO:0050283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-sulfate ammonia-lyase activity
GO:0050283	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(L-SOS)lyase activity
GO:0050283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-sulphate ammonia-lyase activity
RHEA:43615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(341) in tmRNA <=> 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-5221014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine (Homo sapiens)
REACT:R-BTA-444498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin-releasing hormone receptor binds thyrotropin (Bos taurus)
REACT:R-CFA-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Canis familiaris)
RHEA:29758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate(in) <=> (R)-lipoate(out)
REACT:R-CFA-191763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP:Snurportin complex formation (Canis familiaris)
REACT:R-DDI-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Dictyostelium discoideum)
REACT:R-MMU-6800299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGFAC cleaves pro-HGF to form HGF dimer (Mus musculus)
REACT:R-BTA-379426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Bos taurus)
REACT:R-SCE-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Saccharomyces cerevisiae)
REACT:R-DDI-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Dictyostelium discoideum)
RHEA:58074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonate + NADP(+) => a 4,5-didehydrojasmonate + H(+) + NADPH
GO:0071518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-dihydroxy-pentane-2,3-dione kinase activity
GO:0071518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	autoinducer-2 kinase activity
GO:0071518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4,5-dihydroxypentane-2,3-dione + ATP = (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)
GO:0071518	skos:prefLabel	"autoinducer-2 kinase"
GO:0071518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"autoinducer-2 kinase"
REACT:R-CFA-2395869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
REACT:R-DME-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
REACT:R-RNO-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Rattus norvegicus)
RHEA:54026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2
REACT:R-CFA-606326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HJURP:CENPA complex localizes to the centromere (Canis familiaris)
REACT:R-HSA-5654667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
RHEA:44200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyloctadecanoate + ATP + CoA = 12-methyloctadecanoyl-CoA + AMP + diphosphate
RHEA:37633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine
RHEA:34359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + H2O = a 2-acylglycerol + a carboxylate + H(+)
REACT:R-GGA-264615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Gallus gallus)
REACT:R-GGA-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Gallus gallus)
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	baboon ligand
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	baboon binding
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thickveins ligand
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor beta receptor type I binding
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thickveins binding
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	saxophone binding
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta ligand binding to type I receptor
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGF-beta type I binding
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	babo ligand
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sax binding
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	babo binding
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tkv binding
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I transforming growth factor beta receptor binding
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tkv ligand
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sax ligand
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	baboon receptor ligand
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I TGF-beta binding
GO:0034713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	saxophone ligand
RHEA:54865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + sulcatone => 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)
GO:0000497	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	base pairing with DNA
GO:0000497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA template activity
RHEA:47760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:57594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-400682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Rac1 interacts with Plexin-B1:Sema4D (Canis familiaris)
GO:0031808	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H2 histamine receptor ligand
GO:0031808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 histamine receptor binding
REACT:R-RNO-1234164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Rattus norvegicus)
REACT:R-CFA-9008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds ESR1:estrogen:TGFA gene (Canis familiaris)
REACT:R-XTR-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Xenopus tropicalis)
REACT:R-DME-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Drosophila melanogaster)
REACT:R-RNO-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Rattus norvegicus)
REACT:R-SPO-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Schizosaccharomyces pombe)
REACT:R-MMU-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Mus musculus)
RHEA:42431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clavaminate <=> (3R,5R)-clavulanate-9-aldehyde
RHEA:38824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:62759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:64857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + phomopsene
REACT:R-MMU-5696356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSCAR binds collagen and SP-D (Mus musculus)
RHEA:41859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydecanoyl-[ACP] + NADP(+)
REACT:R-SCE-3371518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 binds to HSF1 (Saccharomyces cerevisiae)
REACT:R-SPO-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)
GO:0043287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHA binding
GO:0043287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(3-hydroxyalkanoate) binding
RHEA:32199	skos:prefLabel	"3-ketosteroid 9alpha-monooxygenase"
RHEA:32199	skos:altLabel	"3-ketosteroid 9alpha-hydroxylase"
RHEA:32199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:32199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-ketosteroid 9alpha-monooxygenase"
REACT:R-MMU-8848939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds KHDRBS1 (Mus musculus)
RHEA:45652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-HSA-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Homo sapiens)
RHEA:55214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + pentadecanal => (2R)-hydroxyhexadecanoyl-CoA
REACT:R-RNO-1475422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPS is phosphorylated by cGMP-dependant protein kinase II (Rattus norvegicus)
REACT:R-CEL-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Caenorhabditis elegans)
REACT:R-CFA-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Canis familiaris)
REACT:R-SSC-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Sus scrofa)
GO:0071857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-endorphin receptor binding
REACT:R-HSA-167674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PLCG1 to active TrkA receptor (Homo sapiens)
REACT:R-DRE-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Danio rerio)
REACT:R-HSA-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Homo sapiens)
REACT:R-CFA-9688831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK3 at K55, K363 (Canis familiaris)
RHEA:42174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O => (11Z)-eicosenoyl-CoA + AH2 + O2
RHEA:15891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + NH4(+) => H2O + L-glutamine
RHEA:44131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9E)-octadecenoate
RHEA:59675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotriose + O2 <=> D-maltotriono-1,5-lactone + H2O2
REACT:R-DME-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Drosophila melanogaster)
REACT:R-DME-429732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Drosophila melanogaster)
REACT:R-HSA-9022175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2:CREB1 complex binds SLC2A3 gene (Homo sapiens)
REACT:R-GGA-202713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD84 homodimerises (Gallus gallus)
REACT:R-DME-432507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic TIM is degraded by the 26S proteasome (Drosophila melanogaster)
RHEA:25773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparagine + O2 => (2S,3S)-3-hydroxyasparagine + CO2 + succinate
RHEA:43253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate
RHEA:42398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine => cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine
REACT:R-GGA-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Gallus gallus)
REACT:R-CFA-5682588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 binds phosphorylated MDC1 at DNA DSBs (Canis familiaris)
REACT:R-HSA-9008345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2-P1 binds RUNX2 gene promoter (Homo sapiens)
REACT:R-CEL-947531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)
REACT:R-MMU-349426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MDM4 by CHEK2 (Mus musculus)
GO:0016531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copper chaperone activity
RHEA:59634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylobiono-1,5-lactone + H2O2 => D-xylobiose + O2
RHEA:65706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose
REACT:R-HSA-9035279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of APOC4 regulated by NR1H2 or NR1H3 (Homo sapiens)
REACT:R-RNO-6806831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5Rs reduce MetHb to HbA (Rattus norvegicus)
REACT:R-SSC-5624948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF17 enters the cilium (Sus scrofa)
REACT:R-MMU-1181149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Mus musculus)
REACT:R-BTA-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Bos taurus)
RHEA:25013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-tryptophan = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O
RHEA:33024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NAD(+) => CO2 + D-ribulose 5-phosphate + NADH
REACT:R-BTA-389158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
RHEA:71203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoarginine(in) = L-homoarginine(out)
RHEA:52173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0015599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine-importing ATPase activity
GO:0015599	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-coupled glutamine transmembrane transporter activity
GO:0015599	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine porter activity
GO:0015599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled L-glutamine transmembrane transporter activity
RHEA:55819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine
RHEA:27531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (3S,6E)-nerolidol + diphosphate
REACT:R-HSA-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Homo sapiens)
REACT:R-CEL-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
REACT:R-MMU-8855747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Mus musculus)
RHEA:72770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH <=> 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)
GO:0106346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA methyltransferase activity
RHEA:14255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GDP + H(+) => guanosine 3',5'-bis(diphosphate) + H2O
RHEA:41693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)
REACT:R-GGA-6809521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPIF binds bacteria (Gallus gallus)
RHEA:64194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-lysine => H2O + N-(9Z-octadecenoyl)-L-lysine
RHEA:44477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine
RHEA:71278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurolithocholate 3-sulfate(out) <=> 2 Na(+)(in) + taurolithocholate 3-sulfate(in)
RHEA:68850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + gamma-cadinene => (2Z,6E)-farnesyl diphosphate
RHEA:24709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose
REACT:R-CFA-9021627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
RHEA:20198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparosan-N-sulfate](n) => [heparan-N-sulfate](n)
RHEA:60562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein] => L-methionyl-[protein] + S-adenosyl-L-methionine
REACT:R-BTA-9027607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Bos taurus)
REACT:R-BTA-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Bos taurus)
REACT:R-SSC-3780997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG2:GYS2 (Sus scrofa)
REACT:R-CFA-381518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAAP-A proteolyzes IGF:IGFBP4 (Canis familiaris)
RHEA:10600	skos:altLabel	"prostaglandin-H2 Delta-isomerase"
RHEA:10600	skos:altLabel	"prostaglandin D synthetase"
RHEA:10600	skos:altLabel	"PGD2 synthase"
RHEA:10600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 = prostaglandin D2
RHEA:10600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prostaglandin-D synthase"
RHEA:10600	skos:altLabel	"prostaglandin endoperoxide Delta-isomerase"
RHEA:10600	skos:altLabel	"PGH-PGD isomerase"
RHEA:10600	skos:altLabel	"prostaglandin D2 synthase"
RHEA:10600	skos:prefLabel	"prostaglandin-D synthase"
REACT:R-CFA-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Canis familiaris)
REACT:R-SSC-3266557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I cleaves iC3b (Sus scrofa)
REACT:R-DME-6799097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates ZNF420 (Drosophila melanogaster)
REACT:R-HSA-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Homo sapiens)
RHEA:32989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O
RHEA:29822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-isoleucine(out) <=> ADP + H(+) + L-isoleucine(in) + phosphate
RHEA:51676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [protein]-dithiol + 2 AH2 + H(+) + sulfite
REACT:R-DRE-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Danio rerio)
RHEA:12124	skos:prefLabel	"shikimate O-hydroxycinnamoyltransferase"
RHEA:12124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + shikimate = CoA + trans-4-coumaroylshikimate
RHEA:12124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"shikimate O-hydroxycinnamoyltransferase"
REACT:R-DRE-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Danio rerio)
GO:0043425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bHLH transcription factor binding
REACT:R-SSC-1971491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Sus scrofa)
REACT:R-HSA-9629166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective NEIL1 variants do not cleave Tg (Homo sapiens)
RHEA:61677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP => AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]
REACT:R-HSA-6799191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
RHEA:11432	skos:prefLabel	"vitexin 2''-O-rhamnoside 7-O-methyltransferase"
RHEA:11432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine
RHEA:11432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vitexin 2''-O-rhamnoside 7-O-methyltransferase"
RHEA:30566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-tryptophan <=> 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate
RHEA:72363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out)
REACT:R-XTR-5205822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-18 (H3R17) of histone H3 (Xenopus tropicalis)
RHEA:41981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH
RHEA:13087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + L-2-acetamido-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O
RHEA:19036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-glucosamine <=> an N-acyl-D-mannosamine
RHEA:58904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH = C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)
RHEA:58904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phthioceranic/hydroxyphthioceranic acid synthase"
RHEA:58904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH = C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)
RHEA:58904	skos:altLabel	"PKS2"
RHEA:58904	skos:prefLabel	"phthioceranic/hydroxyphthioceranic acid synthase"
REACT:R-HSA-187698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIT/RIN-GTP binds B-RAF (Homo sapiens)
REACT:R-RNO-1592240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NRF2 (Rattus norvegicus)
GO:0000217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA secondary structure binding
REACT:R-SPO-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Schizosaccharomyces pombe)
RHEA:41974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E))
RHEA:39890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin
EC:2.3.1.255	skos:prefLabel	"N-terminal amino-acid N(alpha)-acetyltransferase NatA"
EC:2.3.1.255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-terminal amino-acid N(alpha)-acetyltransferase NatA"
REACT:R-RNO-6801687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Rattus norvegicus)
RHEA:65823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:20118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-rhamnulose => ADP + H(+) + L-rhamnulose 1-phosphate
GO:0090580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
REACT:R-HSA-5685600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viral HA binds NCRI (Homo sapiens)
REACT:R-XTR-1295632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA2A dephosphorylates SPRY2 (Xenopus tropicalis)
REACT:R-CFA-380278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Canis familiaris)
REACT:R-CFA-159358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A3,4 dimers sulfate DA to DAOS (Canis familiaris)
REACT:R-CFA-5623521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)
RHEA:53792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylthiol + O2 = benzothialdehyde + H2O2
REACT:R-DRE-3134953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 or DHX9 binds MyD88 (Danio rerio)
REACT:R-HSA-9691215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFR2 dimer (Homo sapiens)
REACT:R-GGA-975040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAB-ZNF / KAP Interaction (Gallus gallus)
REACT:R-SSC-1370505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR is phosphorylated at Ser-349 (Sus scrofa)
RHEA:56881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-Delta(5)-steroid + NADP(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADPH
RHEA:25690	skos:altLabel	"CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase"
RHEA:25690	skos:prefLabel	"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase"
RHEA:25690	skos:altLabel	"CDP-unsaturated archaeol synthase"
RHEA:25690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase"
RHEA:25690	skos:altLabel	"CDP-archaeol synthase"
RHEA:25690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate
REACT:R-DME-5610746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI3 (Drosophila melanogaster)
REACT:R-SSC-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Sus scrofa)
REACT:R-CFA-9645414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Canis familiaris)
REACT:R-MMU-114259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase‑9 to caspase‑9 (Mus musculus)
REACT:R-MMU-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Mus musculus)
REACT:R-PFA-110356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MPG glycosylase by APEX1 at the AP site (Plasmodium falciparum)
REACT:R-HSA-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
RHEA:18109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate
RHEA:18109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranylgeranylglycerol-phosphate geranylgeranyltransferase"
RHEA:18109	skos:altLabel	"DGGGPS"
RHEA:18109	skos:altLabel	"DGGGP synthase"
RHEA:18109	skos:altLabel	"(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase"
RHEA:18109	skos:prefLabel	"geranylgeranylglycerol-phosphate geranylgeranyltransferase"
REACT:R-MMU-69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk1 (Mus musculus)
RHEA:28872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructuronate(in) + H(+)(in) => D-fructuronate(out) + H(+)(out)
RHEA:70031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:42283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate
REACT:R-HSA-5653850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)
REACT:R-GGA-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Gallus gallus)
REACT:R-DRE-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Danio rerio)
REACT:R-RNO-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Rattus norvegicus)
REACT:R-DRE-198513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Danio rerio)
REACT:R-CFA-9678766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 binds CYP3A4 inhibitors (Canis familiaris)
RHEA:33493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine => 2-hydroxyhexacosanoyl-CoA + sphinganine
REACT:R-GGA-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Gallus gallus)
REACT:R-MMU-936564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 inhibits MAVS-DDX58 interaction. (Mus musculus)
REACT:R-MMU-909730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of INFAR1 by TYK2 (Mus musculus)
REACT:R-MMU-195690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Mus musculus)
REACT:R-XTR-5693012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF15 binds TNFRSF25 (Xenopus tropicalis)
REACT:R-BTA-8964614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Bos taurus)
RHEA:67991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-glutamine <=> N-acetyl-D-glutamine
GO:0102573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminodeoxyfutalosine synthase activity
RHEA:66965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
REACT:R-HSA-9760122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2-dependent GCLC gene expression (Homo sapiens)
REACT:R-RNO-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Rattus norvegicus)
RHEA:60730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH => citral + H2O + NADP(+)
REACT:R-CEL-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Caenorhabditis elegans)
REACT:R-MMU-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Mus musculus)
REACT:R-HSA-9659782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
REACT:R-CEL-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Caenorhabditis elegans)
REACT:R-HSA-5601849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP19A1 does not convert ANDST to E1 (Homo sapiens)
REACT:R-CFA-265682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Canis familiaris)
REACT:R-RNO-83788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to Type 2 promoter (Rattus norvegicus)
RHEA:70350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + L-tyrosine + NADP(+) <=> 3-bromo-L-tyrosine + NADPH
REACT:R-HSA-9620456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sGC stimulators bind sGC:NO (Homo sapiens)
REACT:R-XTR-2059926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPHP4 protein binds LATS proteins (Xenopus tropicalis)
REACT:R-MMU-8948034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds LDL:LRP8 (Mus musculus)
RHEA:31305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an oxidized flavin + 2 H(+) + NADH => a reduced flavin + NAD(+)
RHEA:49387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Homo sapiens)
REACT:R-MMU-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Mus musculus)
RHEA:16444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutaminyl-[protein] <=> L-glutamyl-[protein] + NH4(+)
REACT:R-DRE-8873929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates STARD10 (Danio rerio)
REACT:R-HSA-1254251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds YAP1 (Homo sapiens)
REACT:R-CFA-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Canis familiaris)
REACT:R-CEL-8854222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D3 associates with RAB5 (Caenorhabditis elegans)
REACT:R-DRE-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Danio rerio)
REACT:R-DDI-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Dictyostelium discoideum)
RHEA:12634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + H(+) + NADH + O2 => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)
REACT:R-CFA-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Canis familiaris)
GO:0044684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromethanopterin reductase activity
REACT:R-CEL-2076508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS2ST1 sulfates IdoA at C2 in heparan sulfate (Caenorhabditis elegans)
RHEA:68748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]
RHEA:21001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene
RHEA:61802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-alanyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-alanine
REACT:R-CEL-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Caenorhabditis elegans)
GO:0009046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Zn(2+) G peptidase activity
GO:0009046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zinc D-Ala-D-Ala carboxypeptidase"
GO:0009046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl-D-alanine-cleaving carboxypeptidase activity
GO:0009046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc D-Ala-D-Ala carboxypeptidase activity
GO:0009046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Zn2+ G peptidase activity
GO:0009046	skos:prefLabel	"zinc D-Ala-D-Ala carboxypeptidase"
GO:0009046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DD-carboxypeptidase-transpeptidase activity
GO:0009046	skos:altLabel	"Zn(2+) G peptidase"
GO:0009046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl-D-alanine hydrolase activity
GO:0009046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	G enzyme
GO:0009046	skos:altLabel	"D-alanyl-D-alanine hydrolase"
GO:0009046	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DD-carboxypeptidase
GO:0004416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyacylglutathione hydrolase"
GO:0004416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxalase II activity
GO:0004416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-(2-hydroxyacyl)glutathione hydrolase activity
GO:0004416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-2-hydroxylacylglutathione hydrolase activity
GO:0004416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
GO:0004416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetylglutathione hydrolase activity
GO:0004416	skos:prefLabel	"hydroxyacylglutathione hydrolase"
GO:0004416	skos:altLabel	"glyoxalase II"
GO:0004416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)
GO:0004416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyacylglutathione hydrolase activity
REACT:R-DRE-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Danio rerio)
REACT:R-SSC-5682983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates WHSC1 (Sus scrofa)
REACT:R-CEL-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)
REACT:R-CFA-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Canis familiaris)
RHEA:48971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 <=> [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O
RHEA:54695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate
RHEA:44469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine
REACT:R-DRE-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Danio rerio)
REACT:R-HSA-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Homo sapiens)
REACT:R-DRE-76373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxylation of 4-aminobiphenyl (Danio rerio)
RHEA:53917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acyl-L-lysyl-[protein]
REACT:R-MMU-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)
RHEA:52163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime <=> (Z)-phenylacetaldehyde oxime
RHEA:48432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]
REACT:R-BTA-9705738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)
RHEA:31414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
RHEA:55283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + tetradecanoyl-CoA <=> 13-cis-retinyl tetradecanoate + CoA
REACT:R-XTR-2161779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LXA4 is oxidised to 15k-LXA4 by HPGD (Xenopus tropicalis)
REACT:R-MMU-6798317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Mus musculus)
REACT:R-RNO-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Rattus norvegicus)
REACT:R-BTA-390427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Bos taurus)
RHEA:63770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine => 2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-PFA-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Plasmodium falciparum)
RHEA:54322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:38595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)
RHEA:49358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DRE-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Danio rerio)
REACT:R-DRE-6810843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin binds periplakin (Danio rerio)
REACT:R-RNO-2396007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3 is phosphorylated by TBK1 (Rattus norvegicus)
RHEA:29255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + Na(+)(out) = Ca(2+)(out) + Na(+)(in)
REACT:R-RNO-9603420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 promotes SRC autophosphorylation (Rattus norvegicus)
REACT:R-DRE-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Danio rerio)
REACT:R-GGA-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Gallus gallus)
RHEA:34367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylamide + H2O = acrylate + NH4(+)
REACT:R-SSC-8983845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dissociates from IL6ST:IL6ST (Sus scrofa)
REACT:R-HSA-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Homo sapiens)
EC:2.3.1.69	skos:prefLabel	"monoterpenol O-acetyltransferase"
EC:2.3.1.69	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monoterpenol O-acetyltransferase"
EC:2.3.1.69	skos:altLabel	"menthol transacetylase"
RHEA:11186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + CO2 + NH4(+) => 3-(carbamoylamino)propanoate + 2 H(+) + H2O
RHEA:14228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexanoate + NAD(+) <=> 6-oxohexanoate + H(+) + NADH
REACT:R-DRE-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Danio rerio)
REACT:R-SSC-2454113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 transports 11cRAL to rod photoreceptor outer segment (Sus scrofa)
REACT:R-CFA-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Canis familiaris)
REACT:R-RNO-110011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Grb10 to the insulin receptor (Rattus norvegicus)
REACT:R-DME-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Drosophila melanogaster)
REACT:R-HSA-70355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALK1 phosphorylates Gal to Gal1P (Homo sapiens)
REACT:R-RNO-4090281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Rattus norvegicus)
GO:0018589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBT dioxygenase activity
GO:0018589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-n-butyltin dioxygenase activity
REACT:R-RNO-5654573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds SHC1 (Rattus norvegicus)
RHEA:71314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-alanine(out) + 2 Na(+)(out) <=> chloride(in) + L-alanine(in) + 2 Na(+)(in)
REACT:R-HSA-525833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 interacts with T- and L-type VDCC (Homo sapiens)
REACT:R-HSA-9708497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 gene produces BACH1 (Homo sapiens)
REACT:R-HSA-9636296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mce3E binds MAPK1 (Homo sapiens)
REACT:R-SSC-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Sus scrofa)
RHEA:40080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Bos taurus)
REACT:R-CFA-211959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A43 6b-hydroxylates TEST (Canis familiaris)
RHEA:18278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thiol + S-adenosyl-L-methionine => a methyl thioether + H(+) + S-adenosyl-L-homocysteine
RHEA:12448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate + H2O = (R)-pantoate + beta-alanine
RHEA:12448	skos:prefLabel	"pantothenase"
RHEA:12448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pantothenase"
GO:0008509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anion transporter activity
GO:0008509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anion transmembrane transporter activity
GO:0008509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion flip-flops to the opposite surface (Homo sapiens)
REACT:R-BTA-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Bos taurus)
REACT:R-BTA-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Bos taurus)
REACT:R-DME-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Drosophila melanogaster)
RHEA:61093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-acetyl-L-citrulline => acetate + L-citrulline
REACT:R-HSA-194642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Homo sapiens)
RHEA:34783	skos:altLabel	"3alpha-hydroxysteroid dehydrogenase"
RHEA:34783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH
RHEA:34783	skos:prefLabel	"3alpha-hydroxysteroid 3-dehydrogenase"
RHEA:34783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha-hydroxysteroid 3-dehydrogenase"
REACT:R-GGA-140748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Gallus gallus)
REACT:R-GGA-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Gallus gallus)
REACT:R-DME-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Drosophila melanogaster)
REACT:R-DRE-5685341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex stabilizes RAD51 filament (Danio rerio)
RHEA:53525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-MMU-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Mus musculus)
REACT:R-BTA-1678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses CS/HS precursor (Bos taurus)
REACT:R-BTA-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Bos taurus)
RHEA:49071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]
REACT:R-XTR-416683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA3E binds to PLXND1 (Xenopus tropicalis)
REACT:R-RNO-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Rattus norvegicus)
REACT:R-SPO-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Schizosaccharomyces pombe)
RHEA:65124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + ethanol = benzyl acetate + CoA
REACT:R-HSA-5602603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway (Homo sapiens)
REACT:R-BTA-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Bos taurus)
REACT:R-CFA-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Canis familiaris)
RHEA:56912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) = (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH
REACT:R-DDI-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Dictyostelium discoideum)
REACT:R-RNO-5666070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Rattus norvegicus)
REACT:R-BTA-158399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein binds SERPING1 (Bos taurus)
REACT:R-DRE-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Danio rerio)
REACT:R-DRE-9009526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Danio rerio)
RHEA:59887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chloride + H(+) + L-lysine + O2 <=> 4-chloro-L-lysine + CO2 + H2O + succinate
REACT:R-SPO-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)
REACT:R-DDI-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Dictyostelium discoideum)
REACT:R-DRE-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Danio rerio)
RHEA:40105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + propanoate => H2O + propanoyl-CoA
REACT:R-HSA-2203480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC11 binds ligands (Homo sapiens)
RHEA:31964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5674132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)
RHEA:30692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + methanol => formaldehyde + 2 H2O
RHEA:33335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctadecanoyl-sn-glycerol + phosphate
REACT:R-DDI-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)
REACT:R-XTR-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Xenopus tropicalis)
REACT:R-HSA-6810239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
REACT:R-MMU-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Mus musculus)
RHEA:68067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-171087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR [endosome membrane] => LDLR [plasma membrane] (Canis familiaris)
RHEA:56468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase"
RHEA:56468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O
RHEA:56468	skos:prefLabel	"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase"
REACT:R-SSC-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Sus scrofa)
REACT:R-MMU-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)
REACT:R-SSC-5138459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A:FZD4 is endocytosed (Sus scrofa)
REACT:R-XTR-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Xenopus tropicalis)
RHEA:64479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate
REACT:R-SPO-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Schizosaccharomyces pombe)
REACT:R-MMU-8875531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS4 (Mus musculus)
RHEA:72188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + sucrose(out) => H(+)(in) + sucrose(in)
REACT:R-MMU-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Mus musculus)
RHEA:66869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate
RHEA:43072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Xenopus tropicalis)
RHEA:25954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde
REACT:R-BTA-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Bos taurus)
REACT:R-MMU-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Mus musculus)
GO:0016880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amide synthase activity
GO:0016880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acid-ammonia (or amide) ligase activity
RHEA:52858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein]
REACT:R-CFA-5625784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Canis familiaris)
RHEA:34074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP
REACT:R-RNO-2993763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Rattus norvegicus)
REACT:R-HSA-9709918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAT3 (Homo sapiens)
REACT:R-MMU-6814675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Mus musculus)
RHEA:18020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-pyruvate <=> CO2 + indole-3-acetaldehyde
REACT:R-MMU-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)
REACT:R-HSA-9706312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to LCK (Homo sapiens)
REACT:R-DRE-192097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Danio rerio)
REACT:R-RNO-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Rattus norvegicus)
REACT:R-MMU-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Mus musculus)
RHEA:19652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + tRNA(Asp) <=> AMP + diphosphate + L-aspartyl-tRNA(Asp)
RHEA:21291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + sn-glycerol 3-phosphate <=> D-glucose 6-phosphate + glycerol
RHEA:31564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene C4 => L-glutamate + leukotriene D4
REACT:R-HSA-1254248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80:YAP1 complex to the nucleus (Homo sapiens)
REACT:R-SSC-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Sus scrofa)
RHEA:41787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) <=> CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)
REACT:R-SSC-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
REACT:R-MMU-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)
REACT:R-DME-5362441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Drosophila melanogaster)
RHEA:21054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopropyl-coenzyme M + H(+) + NADH => (2S)-2-hydroxypropyl-coenzyme M + NAD(+)
RHEA:61161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + UDP-beta-L-rhamnose => H(+) + quercitrin + UDP
GO:0070773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NtQ-amidase activity
GO:0070773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N-terminal glutamine amidohydrolase activity
REACT:R-CFA-5672027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Canis familiaris)
RHEA:37019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-serine + H2O = 3-hydroxypyruvate + AH2 + NH4(+)
RHEA:69203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate
REACT:R-MMU-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Mus musculus)
RHEA:28371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + phosphate => hydrogencarbonate + phosphoenolpyruvate
RHEA:52279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + vanillate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate
REACT:R-XTR-374681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 and NCAM1 engaged in cis-interaction (Xenopus tropicalis)
REACT:R-DME-5654641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
RHEA:60219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate
REACT:R-DME-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Drosophila melanogaster)
REACT:R-SSC-183067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Localization of CBL:GRB2 to the membrane (Sus scrofa)
REACT:R-HSA-9625813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P binds S1PR3 in response to E2 stimulation (Homo sapiens)
RHEA:56472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
REACT:R-CFA-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Canis familiaris)
REACT:R-HSA-2160932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 binds phosphorylated PARD6A (Homo sapiens)
REACT:R-XTR-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Xenopus tropicalis)
REACT:R-DRE-200424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Danio rerio)
REACT:R-GGA-5693108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Gallus gallus)
REACT:R-DRE-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
RHEA:48990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-N-hydroxyrifampicin + H2O + NAD(+) => NADH + O2 + rifampicin
REACT:R-SSC-873926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNGR (Sus scrofa)
REACT:R-DRE-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Danio rerio)
REACT:R-XTR-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Xenopus tropicalis)
REACT:R-HSA-9604247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAG1 binds NOTCH4 (Homo sapiens)
REACT:R-DRE-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)
REACT:R-PFA-110355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MUTYH glycosylase by APEX1 at the AP site (Plasmodium falciparum)
REACT:R-GGA-9698170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Gallus gallus)
REACT:R-MMU-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Mus musculus)
REACT:R-RNO-201639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of GAS2 (Rattus norvegicus)
REACT:R-SCE-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Saccharomyces cerevisiae)
REACT:R-RNO-6786205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Rattus norvegicus)
REACT:R-CEL-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Caenorhabditis elegans)
REACT:R-XTR-196086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Xenopus tropicalis)
RHEA:39518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)
REACT:R-CFA-140664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Canis familiaris)
REACT:R-GGA-5638006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3 hydrolyzes GTP (Gallus gallus)
GO:0031724	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CXCR5 chemokine receptor ligand
GO:0031724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 Burkitt's lymphoma receptor binding
GO:0031724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR5 chemokine receptor binding
REACT:R-PFA-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Plasmodium falciparum)
RHEA:72125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) + O-butanoyl-(R)-carnitine(in) => Na(+)(out) + O-butanoyl-(R)-carnitine(out)
REACT:R-DRE-9038161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Danio rerio)
RHEA:64502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine
REACT:R-DME-4655355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Drosophila melanogaster)
REACT:R-HSA-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)
REACT:R-RNO-3215251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53INP1 and HIPK2 bind TP53 (Rattus norvegicus)
REACT:R-PFA-2161959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Plasmodium falciparum)
RHEA:69791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-phenylalanyl-tRNA(Phe) + H2O = D-phenylalanine + H(+) + tRNA(Phe)
REACT:R-MMU-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Mus musculus)
RHEA:29162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)
REACT:R-SSC-873921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of STAT1 to p-IFNGR1 (Sus scrofa)
REACT:R-BTA-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Bos taurus)
RHEA:31015	skos:prefLabel	"indole-3-carboxylate decarboxylase"
RHEA:31015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-carboxylate = CO2 + indole
RHEA:31015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-carboxylate decarboxylase"
REACT:R-SSC-9731931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds selective ERAs (Sus scrofa)
RHEA:19507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose
RHEA:55007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxylimonen-2-one + NADPH + O2 <=> 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)
REACT:R-XTR-5696021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPGK:Mg2+ phosphorylates Glc to G6P (Xenopus tropicalis)
REACT:R-CFA-187934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Canis familiaris)
REACT:R-SCE-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Saccharomyces cerevisiae)
REACT:R-CFA-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Canis familiaris)
REACT:R-GGA-877269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS-1 and SOCS-3 binds to p-JAK2 (Gallus gallus)
REACT:R-HSA-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Homo sapiens)
RHEA:71971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyglutarate(out) + 3 Na(+)(out) = 3-hydroxyglutarate(in) + 3 Na(+)(in)
REACT:R-DME-5362549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np traffics to the plasma membrane (Drosophila melanogaster)
RHEA:44575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) <=> 2-all-trans-heptaprenylphenol + CO2
REACT:R-RNO-5607058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C:PROCR binds F2R (Rattus norvegicus)
REACT:R-DDI-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
RHEA:21764	skos:altLabel	"heme oxidase"
RHEA:21764	skos:prefLabel	"heme oxygenase (biliverdin-producing)"
RHEA:21764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heme oxygenase (biliverdin-producing)"
RHEA:21764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:21764	skos:altLabel	"heme oxygenase (decyclizing)"
RHEA:21764	skos:altLabel	"heme oxygenase"
REACT:R-BTA-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Bos taurus)
REACT:R-DDI-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Dictyostelium discoideum)
RHEA:67241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-adenosyl-L-methionine + H2O => adenosine + H(+) + L-methionine
REACT:R-CFA-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Canis familiaris)
GO:0015109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromate(in) = chromate(out)
GO:0015109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromate transmembrane transporter activity
REACT:R-RNO-9731632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)
REACT:R-XTR-265682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Xenopus tropicalis)
GO:0051087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chaperone protein binding
GO:0051087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chaperone binding
GO:0051087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	co-chaperone activity
GO:0051087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	co-chaperonin activity
REACT:R-SSC-209061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)
RHEA:58462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacyl-sn-glycero-3-phosphocholine + CoA => an acyl-CoA + sn-glycerol 3-phosphocholine
RHEA:32247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH
RHEA:47060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:39171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyeicosanoyl-CoA + NADP(+)
REACT:R-RNO-3640874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-RibC-AXIN is degraded by the proteasome (Rattus norvegicus)
RHEA:59393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-seryl-[protein] => CoA + O-acetyl-L-seryl-[protein]
REACT:R-RNO-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Rattus norvegicus)
REACT:R-RNO-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Rattus norvegicus)
RHEA:57350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methylanthranilate + H(+) + L-alanine => 3-hydroxy-4-methyl-L-kynurenine + H2O
GO:0033423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCA codon-amino acid adaptor activity
GO:0033423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proline tRNA
REACT:R-SSC-2213195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of anchoring fibrils (Sus scrofa)
REACT:R-MMU-8875576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK,CRKL recruits RAC1 GEF to activated MET (Mus musculus)
REACT:R-BTA-8956025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Bos taurus)
RHEA:46897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)
GO:0106157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[protein] + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate
GO:0106157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-arginine 3-dioxygenase activity
GO:0106157	skos:prefLabel	"[protein]-arginine 3-hydroxylase"
GO:0106157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine 3-hydroxylase activity
GO:0106157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[protein]-arginine 3-hydroxylase"
REACT:R-HSA-5623051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc) (Homo sapiens)
REACT:R-CFA-205306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP1 and KIT (Canis familiaris)
REACT:R-SCE-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)
REACT:R-BTA-388832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds CD28 (Bos taurus)
REACT:R-GGA-8848314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36:IL1RL2 binds IL1RAP-1 (Gallus gallus)
RHEA:67183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + L-glutamyl-[protein] <=> ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate
REACT:R-BTA-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Bos taurus)
REACT:R-DRE-110351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of SMUG1 glycosylase by APEX1 at the AP site (Danio rerio)
REACT:R-SSC-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Sus scrofa)
RHEA:70624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
RHEA:45136	skos:prefLabel	"2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase"
RHEA:45136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O
RHEA:45136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase"
GO:0102708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity
REACT:R-SSC-76475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Sus scrofa)
REACT:R-PFA-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Plasmodium falciparum)
REACT:R-PFA-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
RHEA:13182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + nitrate(out) => ADP + H(+) + nitrate(in) + phosphate
RHEA:63964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-4E,14Z-dienine-1-phosphate = (2E,12Z)-hexadecadienal + phosphoethanolamine
RHEA:67835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate
REACT:R-DME-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Drosophila melanogaster)
REACT:R-DME-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Drosophila melanogaster)
REACT:R-SSC-193965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 18HCORST to ALDO (Sus scrofa)
REACT:R-DRE-9703895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds CASR agonists (Danio rerio)
REACT:R-DME-5624473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Drosophila melanogaster)
RHEA:10069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
REACT:R-PFA-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Plasmodium falciparum)
REACT:R-HSA-4641129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is ubiquitinated by SMURF2 (Homo sapiens)
RHEA:30341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + tryptamine => H(+) + L-tryptophan
REACT:R-RNO-159796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor IX to factor IX (Rattus norvegicus)
REACT:R-DRE-8873794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCTP binds PC (Danio rerio)
RHEA:11607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA
RHEA:15372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + O2 <=> 2-carboxy-cis,cis-muconate + 2 H(+)
REACT:R-MMU-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Mus musculus)
REACT:R-XTR-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Xenopus tropicalis)
RHEA:42447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NADP(+) <=> H(+) + iminosuccinate + NADPH
REACT:R-BTA-425822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Bos taurus)
REACT:R-RNO-2076508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS2ST1 sulfates IdoA at C2 in heparan sulfate (Rattus norvegicus)
RHEA:66323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP(out) <=> 2',3'-cGAMP(in)
REACT:R-MMU-9652580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Mus musculus)
REACT:R-CFA-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Canis familiaris)
REACT:R-CFA-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Canis familiaris)
REACT:R-GGA-5655142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 binds POLH (Gallus gallus)
REACT:R-MMU-8852331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 translocates to the nucleus (Mus musculus)
RHEA:11700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + progesterone = H2O + NADP(+) + testosterone acetate
REACT:R-SSC-5626988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds NSMAF (Sus scrofa)
RHEA:40508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-CEL-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Caenorhabditis elegans)
REACT:R-DRE-4088220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endorepellin binds alpha2beta1 integrin (Danio rerio)
REACT:R-MMU-9020610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Mus musculus)
REACT:R-XTR-8853419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 promotes AURKA autophosphorylation (Xenopus tropicalis)
REACT:R-SSC-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Sus scrofa)
RHEA:25008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Canis familiaris)
RHEA:12050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipyl-CoA + succinate => 3-oxoadipate + succinyl-CoA
REACT:R-GGA-372519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcCho is hydrolyzed to Cho and acetate by ACHE (Gallus gallus)
RHEA:59542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + CO2 => (2R)-ethylmalonyl-CoA + H(+)
REACT:R-DRE-5665809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Danio rerio)
RHEA:47894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
REACT:R-BTA-8954262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Bos taurus)
RHEA:46396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA 11-(E)-desaturase"
RHEA:46396	skos:prefLabel	"acyl-CoA 11-(E)-desaturase"
RHEA:57747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + phylloquinol <=> [protein]-dithiol + phylloquinone
GO:0005308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine transmembrane transporter activity
REACT:R-HSA-5649655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 recognizes and binds DHU-dsDNA (Homo sapiens)
RHEA:65604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + eicosanoyl-CoA = CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine
REACT:R-HSA-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)
REACT:R-HSA-449978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7 binds IL7R:JAK1 (Homo sapiens)
REACT:R-HSA-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Homo sapiens)
RHEA:61639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + isophthalate <=> AMP + diphosphate + isophthalyl-CoA
GO:0047951	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citryl-glutathione thioesterhydrolase activity
GO:0047951	skos:prefLabel	"glutathione thiolesterase"
GO:0047951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione thiolesterase"
GO:0047951	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-acylglutathione hydrolase activity
GO:0047951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-acylglutathione = a carboxylate + glutathione + H(+)
GO:0047951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione thioesterase activity
GO:0047951	skos:altLabel	"glutathione thioesterase"
GO:0047951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione thiolesterase activity
REACT:R-CFA-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Canis familiaris)
RHEA:11905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4-hydroxypteridine + H(+) + H2O => 2,4-dihydroxypteridine + NH4(+)
REACT:R-DDI-375768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Dictyostelium discoideum)
REACT:R-MMU-6787820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds CSF1R (Mus musculus)
RHEA:39372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)
REACT:R-XTR-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Xenopus tropicalis)
GO:0015075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion transmembrane transporter activity
GO:0015075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion transporter activity
REACT:R-SPO-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Schizosaccharomyces pombe)
REACT:R-SSC-8878050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 and EP300 (Sus scrofa)
RHEA:40743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + 2 H2O = (20S)-ginsenoside C-K + 2 D-glucose
RHEA:40743	skos:prefLabel	"ginsenosidase type III"
RHEA:40743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ginsenosidase type III"
REACT:R-DME-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Drosophila melanogaster)
RHEA:12173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)
RHEA:43631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NAD(+) <=> aminoacetaldehyde + CO2 + NADH
REACT:R-MMU-8963915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D binds VDR (Mus musculus)
GO:0034821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citronellol dehydrogenase activity
REACT:R-XTR-8857583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by PTK6 (Xenopus tropicalis)
REACT:R-BTA-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Bos taurus)
RHEA:31730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 + styrene <=> (2S)-2-phenyloxirane + FAD + H(+) + H2O
REACT:R-GGA-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Gallus gallus)
REACT:R-RNO-8964340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq-BTK complex dissociates to Active BTK and Gq (Rattus norvegicus)
REACT:R-DRE-3149519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC decyanates CNCbl (Danio rerio)
RHEA:64574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate + diphosphate => isopentenyl diphosphate + neryl diphosphate
RHEA:63589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin + UDP-alpha-D-glucuronate => prunetin-4'-O-beta-D-glucuronide + UDP
REACT:R-HSA-937032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)
RHEA:65721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + butyl sulfate + O2 => butanal + CO2 + H(+) + succinate + sulfate
REACT:R-XTR-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Xenopus tropicalis)
GO:0016796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
GO:0016796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"
GO:0016796	skos:prefLabel	"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"
GO:0016796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters
REACT:R-BTA-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Bos taurus)
GO:0102264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-dihydrouridine20 synthase activity
REACT:R-MMU-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Mus musculus)
REACT:R-DRE-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Danio rerio)
RHEA:45849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydodecanoyl-CoA + NADP(+) => 3-oxododecanoyl-CoA + H(+) + NADPH
RHEA:27679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dCDP => ADP + dCTP
EC:4.2.2.n1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidoglycan lytic exotransglycosylase"
EC:4.2.2.n1	skos:altLabel	"exomuramidase"
EC:4.2.2.n1	skos:altLabel	"murein lyase F"
EC:4.2.2.n1	skos:prefLabel	"peptidoglycan lytic exotransglycosylase"
RHEA:40702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol <=> 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:43191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2634) in 25S rRNA <=> H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine
REACT:R-GGA-8871227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA4 (Gallus gallus)
RHEA:67338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside) => kaempferol 3-O-beta-D-glucoside + malonyl-CoA
RHEA:22468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GTP cyclohydrolase IIa"
RHEA:22468	skos:prefLabel	"GTP cyclohydrolase IIa"
RHEA:22468	skos:altLabel	"GTP cyclohydrolase III"
RHEA:22468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate
REACT:R-SSC-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Sus scrofa)
RHEA:32163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase"
RHEA:32163	skos:altLabel	"N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine synthase"
RHEA:32163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine = AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine
RHEA:32163	skos:prefLabel	"N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase"
REACT:R-RNO-202331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to SLP-76 (Rattus norvegicus)
REACT:R-CFA-8987040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Canis familiaris)
RHEA:28476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate(out) + H(+)(out) => D-glucarate(in) + H(+)(in)
REACT:R-RNO-1566962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by elastin-degrading extracellular proteinases (Rattus norvegicus)
REACT:R-HSA-9679477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFA inhibitors (Homo sapiens)
REACT:R-BTA-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Bos taurus)
RHEA:59439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] <=> 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate
RHEA:63558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynorphin A-(1-12) + L-lysine => dynorphin A-(1-13) + H2O
RHEA:11198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ribazole 5'-phosphate + H(+) + nicotinate => 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide
RHEA:61094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-citrulline => H2O + N(2)-acetyl-L-citrulline
REACT:R-XTR-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)
REACT:R-HSA-432129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds and phosphorylates LRP8 (Homo sapiens)
REACT:R-SSC-1482887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Sus scrofa)
REACT:R-CFA-5654596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
REACT:R-SCE-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Saccharomyces cerevisiae)
RHEA:10399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + H2O + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH + NH4(+)
REACT:R-MMU-1475025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Mus musculus)
RHEA:59979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + H(+) <=> CO2 + toluene
REACT:R-RNO-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Rattus norvegicus)
RHEA:54967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + phosphate <=> hexadecanoyl phosphate + holo-[ACP]
RHEA:24678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5,6,7,8-tetrahydromethanopterin hydro-lyase"
RHEA:24678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O
RHEA:24678	skos:altLabel	"formaldehyde-activating enzyme"
RHEA:24678	skos:prefLabel	"5,6,7,8-tetrahydromethanopterin hydro-lyase"
REACT:R-HSA-9006503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the PVALB gene promoter (Homo sapiens)
REACT:R-MMU-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Mus musculus)
REACT:R-XTR-6814695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PERP binds desmosomes (Xenopus tropicalis)
RHEA:13966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L,L-cystathionine => L-homocysteine + NH4(+) + pyruvate
RHEA:71557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminoethyl-dUMP in DNA + CO2 => 5-C(alpha)-glycyl-dTMP in DNA + H(+)
RHEA:33515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5,6-dihydroxyindole + O2 = 2 H2O + 2 indole-5,6-quinone
REACT:R-CFA-6787737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3R binds CSF3 dimer (Canis familiaris)
REACT:R-BTA-174959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT1 (Bos taurus)
REACT:R-DRE-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Danio rerio)
REACT:R-SSC-2562541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR4-induced ripoptosome assembly (Sus scrofa)
REACT:R-PFA-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Plasmodium falciparum)
REACT:R-XTR-996755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFPM proteins bind GATA proteins (Xenopus tropicalis)
REACT:R-CFA-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Canis familiaris)
REACT:R-MMU-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Mus musculus)
GO:0000010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	all-trans-heptaprenyl-diphosphate synthase activity
GO:0000010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HepPP synthase activity
GO:0000010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heptaprenyl pyrophosphate synthetase activity
GO:0000010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-hexaprenyltranstransferase activity
GO:0000010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heptaprenyl diphosphate synthase activity
GO:0000010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heptaprenyl pyrophosphate synthase activity
RHEA:72487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + phosphoenolpyruvate(in) = citrate(in) + phosphoenolpyruvate(out)
REACT:R-RNO-77593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage and polyadenylation of Intronless Pre-mRNA (Rattus norvegicus)
RHEA:53850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxo-taurodeoxycholate + H(+) + NADH => NAD(+) + taurocholate
REACT:R-HSA-167433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta-gamma subunits rebind the alpha-GDP subunit (Homo sapiens)
RHEA:60844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-guanosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate
RHEA:48114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine
RHEA:47308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:26471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + 16-hydroxyhexadecanoate => 16-feruloyloxyhexadecanoate + CoA
REACT:R-SSC-5333678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPNEs bind PL (Sus scrofa)
REACT:R-HSA-3903017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PPARGC1A with SUMO1 (Homo sapiens)
REACT:R-SSC-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Sus scrofa)
RHEA:20340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-O-sulfolactate + H2O <=> (R)-lactate + H(+) + sulfate
REACT:R-HSA-5686318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)
REACT:R-XTR-170070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Xenopus tropicalis)
REACT:R-SSC-9629492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves spiroiminodihydantoin (Sus scrofa)
REACT:R-DRE-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Danio rerio)
REACT:R-MMU-5696872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates Ub-MOM proteins (Mus musculus)
REACT:R-DME-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)
RHEA:27419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+) => 2 Fe(III)-[cytochrome] + H2O + nicotinate
REACT:R-PFA-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Plasmodium falciparum)
RHEA:52483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0033218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amide binding
REACT:R-BTA-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Bos taurus)
GO:0045183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation factor activity, non-nucleic acid binding
GO:0102512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity
REACT:R-SPO-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Schizosaccharomyces pombe)
REACT:R-SPO-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Schizosaccharomyces pombe)
GO:0050164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)
GO:0050164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxoglutarate dehydrogenase (NADP+) activity
REACT:R-BTA-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Bos taurus)
REACT:R-CEL-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Caenorhabditis elegans)
REACT:R-XTR-914036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Xenopus tropicalis)
REACT:R-RNO-5685649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPAs translocate from ER membrane to extracellular region (Rattus norvegicus)
RHEA:67606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+) + N(6)-methyl-dAMP => H2O + N(6)-methyl-dATP
RHEA:21685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-beta-alanopine + H2O + NAD(+) => beta-alanine + H(+) + NADH + pyruvate
REACT:R-CFA-9756180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)
RHEA:48543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)
REACT:R-DRE-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Danio rerio)
REACT:R-MMU-75879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Mus musculus)
GO:0050644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity
GO:0050644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-p-coumarate glucosyltransferase activity
EC:3.4.22.67	skos:altLabel	"GP-I"
EC:3.4.22.67	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zingipain"
EC:3.4.22.67	skos:prefLabel	"zingipain"
EC:3.4.22.67	skos:altLabel	"zingibain"
EC:3.4.22.67	skos:altLabel	"GP-II"
EC:3.4.22.67	skos:altLabel	"ginger protease"
REACT:R-SCE-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Saccharomyces cerevisiae)
REACT:R-RNO-6799761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds PPP1R13L (Rattus norvegicus)
RHEA:34589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + pentalenolactone F + succinate => 2-oxoglutarate + O2 + pentalenolactone E
GO:0047711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	blasticidin-S deaminase activity
GO:0047711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	blasticidin-S aminohydrolase activity
REACT:R-HSA-8848586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of cytosolic HXOL to the peroxisome (Homo sapiens)
GO:0047527	skos:prefLabel	"enterobactin synthase"
GO:0047527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(2,3-dihydroxybenzoyl)-serine synthetase activity
GO:0047527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate-serine ligase activity
GO:0047527	skos:altLabel	"N-(2,3-dihydroxybenzoyl)-serine synthetase"
GO:0047527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoate:L-serine ligase activity
GO:0047527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enterobactin synthase"
GO:0047527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoylserine synthetase activity
GO:0047527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine = 6 AMP + 6 diphosphate + enterobactin + 4 H(+)
GO:0047527	skos:altLabel	"2,3-dihydroxybenzoate--serine ligase"
REACT:R-HSA-2972967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter (Homo sapiens)
RHEA:60252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + NADP(+) = acryloyl-CoA + CO2 + NADPH
REACT:R-MMU-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Mus musculus)
REACT:R-MMU-6789092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide anion from oxygen (Mus musculus)
REACT:R-HSA-8964561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds MYBL2 gene promoter (Homo sapiens)
REACT:R-MMU-170055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Mus musculus)
RHEA:24629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 3 NAD(+) + NH4(+) => 5 H(+) + 3 NADH + nitrite
RHEA:10223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tyrosine + tRNA(Tyr) <=> AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)
GO:0008194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Homo sapiens)
GO:0008194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glycosyltransferase activity
REACT:R-SSC-199518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3d-complexed antigen binds to complement receptor (Sus scrofa)
RHEA:61380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O = 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate
REACT:R-CFA-5634802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Canis familiaris)
REACT:R-RNO-74707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IRS to insulin receptor (Rattus norvegicus)
RHEA:57019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-422454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polysialylation of NCAM1 (Xenopus tropicalis)
RHEA:45661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
RHEA:53136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH
RHEA:64069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-phenylacetylcarbinol + NAD(+) => 1-phenyl-1,2-propanedione + H(+) + NADH
REACT:R-CEL-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Caenorhabditis elegans)
REACT:R-BTA-158251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Bos taurus)
REACT:R-MMU-3697894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN2 (Mus musculus)
RHEA:26293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'S)-averufin + NADPH + O2 = 1'-hydroxyversicolorone + H2O + NADP(+)
REACT:R-XTR-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Xenopus tropicalis)
REACT:R-BTA-917814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Bos taurus)
RHEA:63794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O
REACT:R-SSC-2168881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Truncated Alpha-1-Microglobulin binds heme (Sus scrofa)
REACT:R-HSA-5617431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retinoic acid activates HOXA1 chromatin (Homo sapiens)
REACT:R-XTR-109699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
RHEA:16975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxypyridine + A + H2O => 2-hydroxypyridine + AH2 + O2
REACT:R-HSA-430311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rsu-1 interacts with Pinch1 (Homo sapiens)
REACT:R-HSA-688985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63 polyubiquitinated RIP2 associates with the TAK1 complex (Homo sapiens)
REACT:R-HSA-2467633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds LRP4:MUSK (Homo sapiens)
REACT:R-HSA-114361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP within apoptosome (Homo sapiens)
RHEA:39412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O
RHEA:45491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]
RHEA:53937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + S-adenosyl-L-methionine = H(+) + isorhamnetin + S-adenosyl-L-homocysteine
RHEA:37251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteamine S-phosphate + H2O = cysteamine + phosphate
REACT:R-DME-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Drosophila melanogaster)
REACT:R-HSA-5691381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYSM1 deubiquitinates Histone H2A (Homo sapiens)
REACT:R-DRE-373086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR10 binds CCL27 and 28 ligands (Danio rerio)
REACT:R-HSA-1791156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TATDN2 (Homo sapiens)
REACT:R-HSA-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Homo sapiens)
RHEA:72953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(in) + 2 Na(+)(in) => butanoate(out) + 2 Na(+)(out)
REACT:R-CFA-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Canis familiaris)
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoprotein 3-alpha-L-fucosyltransferase activity
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity
GO:0018392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity
REACT:R-DRE-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Danio rerio)
RHEA:11571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP <=> 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate
REACT:R-HSA-8854908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates RET:GDNF:GFRA dimer (Homo sapiens)
REACT:R-XTR-112266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Xenopus tropicalis)
GO:0018619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene + H(+) + NADH + O2 = cis-1,2-dihydrobenzene-1,2-diol + NAD(+)
GO:0018619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
GO:0018619	skos:prefLabel	"benzene 1,2-dioxygenase"
GO:0018619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzene dioxygenase activity
GO:0018619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzene 1,2-dioxygenase"
GO:0018619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene 1,2-dioxygenase activity
GO:0018619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzene hydroxylase activity
GO:0018619	skos:altLabel	"benzene hydroxylase"
REACT:R-BTA-112437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NELF complex  (Bos taurus)
REACT:R-BTA-5623519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP and RAB8A bind to the ciliary targeting complex (Bos taurus)
REACT:R-SSC-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Sus scrofa)
EC:3.6.5.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on GTP; involved in cellular and subcellular movement"
EC:3.6.5.-	skos:prefLabel	"Acting on GTP; involved in cellular and subcellular movement"
REACT:R-DDI-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Dictyostelium discoideum)
RHEA:19464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)
REACT:R-SSC-4085087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Sus scrofa)
RHEA:48438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic alcohol + H(+) + pentanoate => H2O + pentanoate ester
RHEA:20769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphonopyruvate + H(+) => CO2 + phosphonoacetaldehyde
REACT:R-RNO-5654586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS binds GRB2:SOS1 (Rattus norvegicus)
RHEA:67625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-5654596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
REACT:R-HSA-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Homo sapiens)
REACT:R-DME-2076383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3ST1 sulfates GlcN at C3 in heparan sulfate (Drosophila melanogaster)
REACT:R-DDI-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Dictyostelium discoideum)
RHEA:71405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-159826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Rattus norvegicus)
RHEA:67219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA <=> (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O
RHEA:25842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-2-deoxy-D-gluconate => 5-deoxy-D-glucuronate
GO:0015204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Homo sapiens)
GO:0015204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea transmembrane transporter activity
GO:0015204	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	urea transporter activity
GO:0015204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea(in) = urea(out)
REACT:R-DRE-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Danio rerio)
REACT:R-SSC-5205799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Sus scrofa)
REACT:R-BTA-5627275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOPC promotes translocation of CFTR to lysosomes (Bos taurus)
RHEA:49915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)
REACT:R-MMU-1306876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 activation by small molecules (Mus musculus)
REACT:R-RNO-6807134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Rattus norvegicus)
RHEA:23672	skos:altLabel	"NAD(P)(+)-independent quinate dehydrogenase"
RHEA:23672	skos:prefLabel	"quinate/shikimate dehydrogenase (quinone)"
RHEA:23672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinate/shikimate dehydrogenase (quinone)"
RHEA:23672	skos:altLabel	"quinate dehydrogenase (quinone)"
RHEA:23672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + L-quinate = 3-dehydroquinate + a quinol
REACT:R-CFA-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Canis familiaris)
RHEA:41371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)
REACT:R-GGA-8931981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ESR1 (Gallus gallus)
RHEA:19957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H(+)
RHEA:71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxusin
REACT:R-DRE-199425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLPP dephosphorylates S473 in AKT (Danio rerio)
REACT:R-RNO-374686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 interaction with Integrins (Rattus norvegicus)
RHEA:41011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) = (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)
REACT:R-SCE-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Saccharomyces cerevisiae)
REACT:R-DRE-6799203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Danio rerio)
RHEA:29331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + 2 H(+)(in) = fumarate(out) + 2 H(+)(out)
RHEA:23901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-stilbene oxide + H2O => (1R,2R)-hydrobenzoin
REACT:R-RNO-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Rattus norvegicus)
REACT:R-DRE-9690439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds LTC4,LTD4,LTE4 (Danio rerio)
REACT:R-HSA-199046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligands bind L-selectin (Homo sapiens)
REACT:R-XTR-482770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet secretory granule components (Xenopus tropicalis)
RHEA:61800	skos:prefLabel	"L-alanine--[L-alanyl-carrier protein] ligase"
RHEA:61800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-alanine--[L-alanyl-carrier protein] ligase"
RHEA:61800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-alanine = AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]
REACT:R-SSC-70555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Sus scrofa)
RHEA:20776	skos:altLabel	"galactinol-raffinose galactosyltransferase"
RHEA:20776	skos:altLabel	"stachyose synthetase"
RHEA:20776	skos:prefLabel	"galactinol--raffinose galactosyltransferase"
RHEA:20776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactinol--raffinose galactosyltransferase"
RHEA:20776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = myo-inositol + stachyose
REACT:R-SCE-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Saccharomyces cerevisiae)
RHEA:46607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[HPr protein]-O-phospho-L-serine + H(+) + phosphate <=> [HPr protein]-L-serine + diphosphate
REACT:R-HSA-8857662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Homo sapiens)
REACT:R-CEL-9757688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDN (Caenorhabditis elegans)
REACT:R-CFA-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Canis familiaris)
REACT:R-CFA-9604328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates NOTCH4 (Canis familiaris)
REACT:R-DDI-9026007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Dictyostelium discoideum)
REACT:R-RNO-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Rattus norvegicus)
RHEA:70218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + H(+) + NADPH <=> 20beta-dihydrocortisol + NADP(+)
RHEA:51018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate => 7,8-dihydroneopterin 3'-phosphate
REACT:R-SPO-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Schizosaccharomyces pombe)
RHEA:65565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine
REACT:R-SSC-351210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Sus scrofa)
GO:0030591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine DNA ADP-ribosyltransferase activity
GO:0030591	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD DNA ADP-ribosyltransferase activity
REACT:R-SCE-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)
RHEA:38203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:48972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphite(out) = ADP + H(+) + phosphate + phosphite(in)
RHEA:18208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + progesterone <=> 11alpha-hydroxyprogesterone + A + H2O
RHEA:17741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + shikimate = 3-dehydroshikimate + H(+) + NADH
REACT:R-HSA-202727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaMbeta2 (MAC1) binds JAM3 (Homo sapiens)
RHEA:57458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP => (E)-sinapate + UDP-alpha-D-glucose
REACT:R-XTR-4827382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Xenopus tropicalis)
RHEA:43038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + H(+) + hydrogen sulfide => L-cysteine
RHEA:18611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-acetyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-acetyl-L-ornithine
REACT:R-CFA-444879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 2 binds relaxin 2 and INSL3 (Canis familiaris)
RHEA:53017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorohydroquinone + 2 glutathione => chloride + glutathione disulfide + H(+) + hydroquinone
RHEA:33049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]
REACT:R-HSA-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Homo sapiens)
REACT:R-RNO-5690046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT2 hydrolyses PALMCoA to PALM (Rattus norvegicus)
REACT:R-DME-209133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 'destruction complex' (Drosophila melanogaster)
REACT:R-DRE-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Danio rerio)
REACT:R-SCE-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
REACT:R-SSC-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Sus scrofa)
RHEA:30806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + H2O + NADP(+) <=> 4-aminobutanoate + 2 H(+) + NADPH
RHEA:59000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + propanal = H(+) + H2O2 + propanoate
RHEA:41590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-XTR-9603983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeX to form LeY (Xenopus tropicalis)
RHEA:68435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutein + O2 <=> (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal
REACT:R-DRE-374248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR3 binds ligands CXCL9 to 11 (Danio rerio)
REACT:R-MMU-451418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates IRAK1 (Mus musculus)
RHEA:70712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(in) => D-alanine(out)
REACT:R-RNO-5357780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Rattus norvegicus)
REACT:R-BTA-2395879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
RHEA:71652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine in DNA + NAD(+) => an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide
REACT:R-MMU-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Mus musculus)
REACT:R-CEL-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)
REACT:R-DRE-1793186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Danio rerio)
GO:0050786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	advanced glycation end-product receptor binding
GO:0050786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAGE receptor binding
GO:0015394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine:proton symporter activity
GO:0015394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside (uridine) permease activity
GO:0015394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine:hydrogen ion symporter activity
REACT:R-BTA-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Bos taurus)
RHEA:52927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-MMU-451366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38MAPK by DSCAM (Mus musculus)
REACT:R-BTA-2029272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of PLCG from FCGR (Bos taurus)
REACT:R-HSA-9761822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds the IDH1 gene (Homo sapiens)
REACT:R-DRE-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Danio rerio)
RHEA:71551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine
REACT:R-HSA-6798081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members stimulate CASP1 expression (Homo sapiens)
RHEA:11357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H(+) + NADH => AH2 + NAD(+)
RHEA:31667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase"
RHEA:31667	skos:altLabel	"dTDP-3-keto-6-deoxy-D-glucose 3-aminotransferase"
RHEA:31667	skos:altLabel	"dTDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase"
RHEA:31667	skos:altLabel	"TDP-3-keto-6-deoxy-D-glucose 3-aminotransferase"
RHEA:31667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
RHEA:31667	skos:altLabel	"TDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase"
RHEA:31667	skos:prefLabel	"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase"
REACT:R-CEL-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Caenorhabditis elegans)
REACT:R-MMU-1234164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Mus musculus)
REACT:R-BTA-6804276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TTC5 (Bos taurus)
RHEA:32692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (E)-beta-ocimene + diphosphate
REACT:R-XTR-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)
RHEA:45792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 = [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate
RHEA:47150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,7-trimethylurate + a ubiquinol => a ubiquinone + caffeine + H2O
REACT:R-DME-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Drosophila melanogaster)
RHEA:31287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA = acryloyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:11846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + pyruvate => acetyl-CoA + formate
REACT:R-MMU-193533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)
RHEA:67016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]
REACT:R-CFA-5638004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 binds ARL3:GTP:UNC119B (Canis familiaris)
RHEA:14754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59224	skos:prefLabel	"hydropyrene synthase"
RHEA:59224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + hydropyrene
RHEA:59224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydropyrene synthase"
REACT:R-DRE-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Danio rerio)
REACT:R-GGA-2424485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-PLCG1 (Gallus gallus)
REACT:R-GGA-573296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)
RHEA:21218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => ATP + D-ribose 5-phosphate
REACT:R-DRE-3928654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin internalises EPH:EFN complexes (Danio rerio)
REACT:R-DME-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Drosophila melanogaster)
RHEA:10532	skos:altLabel	"indoleglycerol phosphate aldolase"
RHEA:10532	skos:altLabel	"L-tryptophan synthetase"
RHEA:10532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan
RHEA:10532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan synthase"
RHEA:10532	skos:prefLabel	"tryptophan synthase"
RHEA:10532	skos:altLabel	"tryptophan synthetase"
RHEA:10532	skos:altLabel	"tryptophan desmolase"
REACT:R-BTA-1236967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alkalization of the phagosomal lumen by NOX2 (Bos taurus)
REACT:R-BTA-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
REACT:R-DDI-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Dictyostelium discoideum)
REACT:R-RNO-6807224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-BGLAP to BGLAP (Rattus norvegicus)
REACT:R-SSC-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Sus scrofa)
RHEA:32379	skos:prefLabel	"limonene-1,2-diol dehydrogenase"
RHEA:32379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limonene-1,2-diol dehydrogenase"
RHEA:32379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,4S)-limonene-1,2-diol + NAD(+) = (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH
RHEA:32379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-limonene-1,2-diol + NAD(+) = (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH
RHEA:20211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + xylitol 5-phosphate => ATP + xylitol
REACT:R-CEL-349593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with Fibronectin (Caenorhabditis elegans)
REACT:R-SSC-5626681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of transition zone proteins (Sus scrofa)
REACT:R-CEL-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Caenorhabditis elegans)
RHEA:65601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5,8-trihydroxycasbene + 2 NAD(+) => 2 H(+) + jolkinol C + 2 NADH
REACT:R-CFA-442387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP8 mediates zinc influx into cells (Canis familiaris)
REACT:R-HSA-6789160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ (Homo sapiens)
REACT:R-CEL-377644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of CSK from SRC (Caenorhabditis elegans)
REACT:R-SSC-1675473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B binds JAK2 (Sus scrofa)
RHEA:54155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-1433506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APS (Gallus gallus)
RHEA:51283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-HSA-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Homo sapiens)
REACT:R-XTR-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Xenopus tropicalis)
REACT:R-SSC-5357780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Sus scrofa)
REACT:R-RNO-909730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of INFAR1 by TYK2 (Rattus norvegicus)
REACT:R-DRE-982807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation of GHR (Danio rerio)
RHEA:37047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-histidine(out) = H(+)(in) + L-histidine(in)
RHEA:20914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + taxa-4,11-diene => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-DME-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
REACT:R-SPO-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Schizosaccharomyces pombe)
RHEA:12720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
REACT:R-MMU-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Mus musculus)
REACT:R-XTR-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Xenopus tropicalis)
REACT:R-CFA-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Canis familiaris)
REACT:R-BTA-2545203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cleaved cohesin (Bos taurus)
RHEA:67704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate
RHEA:56857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + an aldehyde + H2O => a carboxylate + AH2 + H(+)
GO:0018449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenylethanol dehydrogenase activity
RHEA:37863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:33239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine + NAD(+) = aminoacetone + CO2 + NADH
EC:3.1.3.62	skos:altLabel	"inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase"
EC:3.1.3.62	skos:altLabel	"inositol-1,3,4,5-tetrakisphosphate 3-phosphatase"
EC:3.1.3.62	skos:altLabel	"inositol tetrakisphosphate phosphomonoesterase"
EC:3.1.3.62	skos:altLabel	"MIPP"
EC:3.1.3.62	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"multiple inositol-polyphosphate phosphatase"
EC:3.1.3.62	skos:altLabel	"inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase"
EC:3.1.3.62	skos:prefLabel	"multiple inositol-polyphosphate phosphatase"
EC:3.1.3.62	skos:altLabel	"inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase"
REACT:R-CEL-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)
RHEA:30623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-neurosporene = AH2 + all-trans-lycopene
RHEA:60224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate
RHEA:60224	skos:prefLabel	"[histone H3]-trimethyl-L-lysine(27) demethylase"
RHEA:60224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-trimethyl-L-lysine(27) demethylase"
REACT:R-MMU-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Mus musculus)
RHEA:19168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP
RHEA:15465	skos:altLabel	"sphingoid base kinase"
RHEA:15465	skos:prefLabel	"sphingosine kinase"
RHEA:15465	skos:altLabel	"sphinganine kinase"
RHEA:15465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingosine kinase"
RHEA:15465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate
RHEA:15465	skos:altLabel	"dihydrosphingosine kinase"
RHEA:21143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + inosine <=> ADP + H(+) + IMP
REACT:R-CFA-9026005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Canis familiaris)
GO:0045131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-mRNA branch point binding
REACT:R-SSC-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Sus scrofa)
REACT:R-SPO-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Schizosaccharomyces pombe)
REACT:R-DME-214878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex' (Drosophila melanogaster)
REACT:R-GGA-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Gallus gallus)
RHEA:10750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O => H(+) + hydrogencarbonate
RHEA:18916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)
RHEA:32039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = AMP + ATP + 2 H(+)
REACT:R-GGA-1295621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
REACT:R-DRE-165162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TSC2 by PKB (Danio rerio)
REACT:R-XTR-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)
REACT:R-XTR-5635864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH ubiquitinates GLI1 (Xenopus tropicalis)
RHEA:45859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-SSC-8950741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B:IL23A translocates from ER lumen to extracellular space (Sus scrofa)
REACT:R-HSA-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
RHEA:63011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-octadecenamide + H2O <=> (6Z)-octadecenoate + NH4(+)
REACT:R-GGA-264976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Gallus gallus)
RHEA:17907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + H(+) + NADH => (R)-glycerate + NAD(+)
REACT:R-RNO-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Rattus norvegicus)
RHEA:72486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + citrate(out) <=> (S)-malate(out) + citrate(in)
GO:0050736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-malonyltransferase activity
RHEA:44420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)
REACT:R-CFA-5610760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by ITCH (Canis familiaris)
REACT:R-RNO-5676592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xRANK binds RANKL,sRANKL trimer:RANK (Rattus norvegicus)
REACT:R-MMU-1482827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Mus musculus)
RHEA:52301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Xenopus tropicalis)
RHEA:31837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-dehydro-6-deoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose
RHEA:47889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
REACT:R-SSC-139918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BIM by JNK (Sus scrofa)
REACT:R-DRE-6799777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind PPP1R13B or TP53BP2 (Danio rerio)
GO:0004122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine hydro-lyase (adding homocysteine)
GO:0004122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine sulfhydrylase activity
GO:0004122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cystathionine beta-synthase activity
GO:0004122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
GO:0004122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Homo sapiens)
GO:0004122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylcysteine synthase activity
GO:0004122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-thionase activity
GO:0004122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine sulfhydrase activity
REACT:R-SSC-83803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Sus scrofa)
RHEA:59716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaono-1,5-lactone + H2O = D-maltopentaonate + H(+)
REACT:R-RNO-9648017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 binds to microtubules (Rattus norvegicus)
GO:0102645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17(E)-cheilanthenediol synthase activity
REACT:R-SSC-5687675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates remaining SSBs in MMEJ (Sus scrofa)
RHEA:46874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA
REACT:R-CFA-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Canis familiaris)
RHEA:21593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) => H(+) + L-2-aminopentanoate + NADH + pyruvate
RHEA:44034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxy-(12Z)-octadecenoate => 9,10-epoxy-(12Z)-octadecenoate + H2O
RHEA:30277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 2 H2O => AH2 + H2O2
RHEA:12611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine => mercaptopurine + S-adenosyl-L-methionine
RHEA:24738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
RHEA:46354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O
RHEA:40187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H2O = (3R)-hydroxyoctanoyl-CoA
RHEA:69369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) => 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH
RHEA:24138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+) => 3'-phosphoadenylyl sulfate + a primary amine
REACT:R-GGA-9021601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Gallus gallus)
RHEA:54152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-2395873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Homo sapiens)
REACT:R-MMU-205231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of KIT upon SCF binding (Mus musculus)
REACT:R-BTA-199093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXADR binds to AMICA1 (Bos taurus)
RHEA:59339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-all-trans-1,2-dihydro-neurosporene + A <=> AH2 + demethylspheroidene
REACT:R-DME-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Drosophila melanogaster)
REACT:R-HSA-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)
REACT:R-SSC-1671687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR activation (Sus scrofa)
RHEA:12218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-fluoren-9-one + H(+) + NADH => 9H-fluoren-9-ol + NAD(+)
RHEA:62963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol(in) <=> 7-dehydrocholesterol(out)
REACT:R-CFA-9603991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Canis familiaris)
REACT:R-PFA-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Plasmodium falciparum)
REACT:R-DRE-4085992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DAXX with SUMO1 (Danio rerio)
REACT:R-RNO-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Rattus norvegicus)
REACT:R-SSC-9029150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Sus scrofa)
REACT:R-DRE-5668731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX3 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)
REACT:R-GGA-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Gallus gallus)
REACT:R-BTA-2022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to heparan (Bos taurus)
REACT:R-RNO-3239019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK5 (Rattus norvegicus)
REACT:R-SCE-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Saccharomyces cerevisiae)
REACT:R-MMU-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Mus musculus)
REACT:R-HSA-5665989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIAPH1 binds RHOA:GTP (Homo sapiens)
RHEA:24799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O
REACT:R-HSA-5654425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds SHC1 (Homo sapiens)
REACT:R-GGA-449976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)
REACT:R-DRE-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Danio rerio)
RHEA:64553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-469659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A1 dehydrogenates TEST to DHTEST (Xenopus tropicalis)
REACT:R-SSC-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Sus scrofa)
RHEA:18967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + uroporphyrinogen III => hydroxymethylbilane
RHEA:38650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)
RHEA:23756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H(+) + H2O2
RHEA:23756	skos:prefLabel	"D-arabinono-1,4-lactone oxidase"
RHEA:23756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arabinono-1,4-lactone oxidase"
RHEA:23756	skos:altLabel	"D-arabinono-gamma-lactone oxidase"
REACT:R-HSA-9604471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT4 gene expression is stimulated by NOTCH4 (Homo sapiens)
RHEA:15209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH
REACT:R-XTR-508162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Xenopus tropicalis)
REACT:R-BTA-6801776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A binds bacterial phospholipids (Bos taurus)
RHEA:15269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylo-hex-3-ulonolactone = H(+) + L-ascorbate
REACT:R-DME-9707523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to BACH1:MAFK (Drosophila melanogaster)
REACT:R-RNO-977348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHGDH tetramer dehydrogenates 3PG (Rattus norvegicus)
RHEA:17389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH
RHEA:17389	skos:altLabel	"D-arabinitol 2-dehydrogenase (ribulose-forming)"
RHEA:17389	skos:prefLabel	"D-arabinitol 2-dehydrogenase"
RHEA:17389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arabinitol 2-dehydrogenase"
RHEA:49471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose <=> a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP
REACT:R-CEL-5696021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPGK:Mg2+ phosphorylates Glc to G6P (Caenorhabditis elegans)
GO:0030527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of chromatin
REACT:R-DRE-1855169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)
GO:0008802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BetB
GO:0008802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	betaine aldehyde oxidase activity
GO:0008802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	betaine-aldehyde:NAD+ oxidoreductase activity
GO:0008802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BADH activity
GO:0008802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine-aldehyde dehydrogenase activity
GO:0008802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	betaine aldehyde dehydrogenase activity
REACT:R-DRE-349455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MDM4 by ATM (Danio rerio)
REACT:R-DRE-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Danio rerio)
GO:0008814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate CoA-transferase activity
GO:0008814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:citrate CoA-transferase activity
RHEA:25362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]
RHEA:36563	skos:prefLabel	"GDP-L-colitose synthase"
RHEA:36563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-colitose + NAD(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH
RHEA:36563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-colitose + NADP(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH
RHEA:36563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-L-colitose synthase"
RHEA:42946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(40) in tRNA precursor + S-adenosyl-L-methionine
RHEA:63405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichloropyridine-2,5-diol + FADH2 + O2 => 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O
RHEA:61163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + UDP-beta-L-rhamnose <=> H(+) + quercitrin + UDP
REACT:R-HSA-2161651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGE2 is converted to PGF2a by CBR1 (Homo sapiens)
RHEA:27362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + S-adenosyl-L-methionine => chloromethane + S-adenosyl-L-homocysteine
REACT:R-HSA-381798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)
REACT:R-DME-2430535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL phosphorylates ENSA (Drosophila melanogaster)
RHEA:21554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate
RHEA:17141	skos:prefLabel	"glycine--oxaloacetate transaminase"
RHEA:17141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine--oxaloacetate transaminase"
RHEA:17141	skos:altLabel	"glycine--oxaloacetate aminotransferase"
RHEA:17141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + oxaloacetate = glyoxylate + L-aspartate
RHEA:68710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + linalool => (2E)-geranyl diphosphate + H2O
GO:0042605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide antigen binding
GO:0042605	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endogenous peptide antigen binding
GO:0042605	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	exogenous peptide antigen binding
REACT:R-HSA-6799199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Homo sapiens)
REACT:R-RNO-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Rattus norvegicus)
RHEA:66378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose + phosphate => D-erythrose 4-phosphate + H2O
RHEA:23689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + H(+) + H2O => hypoxanthine + NH4(+)
RHEA:31708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al
REACT:R-MMU-450490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B/Akt phosphorylates BRF1 (Mus musculus)
RHEA:27328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:34555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH
REACT:R-GGA-158278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Gallus gallus)
REACT:R-HSA-5610766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Homo sapiens)
REACT:R-RNO-1855153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Rattus norvegicus)
RHEA:67791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin
REACT:R-BTA-3788075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by ADAMTS4, ADAMTS5 (Bos taurus)
RHEA:26017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7-dideoxy-D-threo-hepto-2,6-diuolosonate <=> 3-dehydroquinate
GO:0010698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyltransferase stimulator activity
GO:0010698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyltransferase activator activity
REACT:R-HSA-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Homo sapiens)
RHEA:28049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + propanoyl-CoA <=> CoA + propanoyl phosphate
RHEA:30673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose
RHEA:58024	skos:prefLabel	"oleanolate 3-O-glucosyltransferase"
RHEA:58024	skos:altLabel	"UGT73C11"
RHEA:58024	skos:altLabel	"UGT73C10"
RHEA:58024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oleanolate 3-O-glucosyltransferase"
RHEA:58024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleanolate + UDP-alpha-D-glucose = H(+) + oleanolate 3-O-beta-D-glucoside + UDP
RHEA:72781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 H2O + ochratoxin A => chloride + FADH2 + O2 + ochratoxin B
RHEA:37776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-HSA-4719375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective DPM2 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)
REACT:R-DME-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Drosophila melanogaster)
RHEA:33657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate(in) => (9Z)-octadecenoate(out)
REACT:R-BTA-8879117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT2 transfers GlcNAc to Man-DAG1 (Bos taurus)
REACT:R-PFA-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Plasmodium falciparum)
REACT:R-CFA-9007926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATRX binds DAXX (Canis familiaris)
RHEA:65134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + preaustinoid A2 + succinate => 2-oxoglutarate + O2 + preaustinoid A1
REACT:R-DRE-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Danio rerio)
RHEA:17311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenol + acetate + H(+) => a phenyl acetate + H2O
RHEA:33825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + tetrahydro-4-hydroxyphenylpyruvate => 3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH
REACT:R-GGA-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
REACT:R-RNO-8987161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Rattus norvegicus)
RHEA:19160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O
REACT:R-HSA-8874209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L4 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)
REACT:R-MMU-6784006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Mus musculus)
RHEA:35829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine + urea => H2O + N(1)-aminopropylagmatine
RHEA:13558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-cysteine + glycine => ADP + glutathione + H(+) + phosphate
REACT:R-MMU-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Mus musculus)
REACT:R-GGA-5362500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Gallus gallus)
RHEA:69966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone
RHEA:41654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+) => aclacinomycin S + dTDP-2-deoxy-beta-L-fucose
REACT:R-MMU-9753676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1,2 acetylate APAP-Cys to APAP-Mer (Mus musculus)
REACT:R-SSC-109514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Sus scrofa)
REACT:R-HSA-5638332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)
REACT:R-DME-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Drosophila melanogaster)
REACT:R-DRE-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Danio rerio)
GO:0034322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol O-decanoyltransferase activity
RHEA:22790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(methylsulfanyl)acetate + H(+) + L-methionine => dimethylsulfonioacetate + L-homocysteine
REACT:R-HSA-266089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Discoidal HDL binds membrane-associated free cholesterol (Homo sapiens)
REACT:R-HSA-9705681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPP5 binds SARS-CoV-2 E pentamer (Homo sapiens)
GO:0102082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylrebeccamycin--D-glucose O-methyltransferase activity
REACT:R-BTA-5263616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)
RHEA:36833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 caldariellaquinone + n H(+)(out) + 2 H2O => 2 caldariellaquinol + n H(+)(in) + O2
RHEA:10089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + UDP-alpha-D-galactose => 6(F)-alpha-D-galactosylsucrose + H(+) + UDP
RHEA:62058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose
REACT:R-SSC-177922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR dimerization (Sus scrofa)
REACT:R-HSA-416510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK5 sequesters activated Gq (Homo sapiens)
REACT:R-CEL-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Caenorhabditis elegans)
REACT:R-XTR-9025995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Xenopus tropicalis)
REACT:R-DRE-2993447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6x(PCCA:PCCB) (Danio rerio)
RHEA:25164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + butanoyl-CoA = (2E)-butenoyl-CoA + AH2
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-diaminononanoate transaminase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-diaminonanoate transaminase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-diaminopelargonic acid aminotransferase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAPA transaminase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosyl methionine-8-amino-7-oxononanoate transaminase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-diamino-pelargonic acid aminotransferase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-diaminononanoate aminotransferase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-keto-8-aminopelargonic acid aminotransferase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-keto-8-aminopelargonic acid
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diaminopelargonate synthase activity
GO:0004015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAPA aminotransferase activity
REACT:R-BTA-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Bos taurus)
REACT:R-SSC-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Sus scrofa)
REACT:R-DDI-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Dictyostelium discoideum)
REACT:R-CFA-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Canis familiaris)
RHEA:64017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)
RHEA:20813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citryl-CoA => acetyl-CoA + oxaloacetate
RHEA:21608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoliquiritigenin + S-adenosyl-L-methionine = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine
RHEA:21608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoliquiritigenin 2'-O-methyltransferase"
RHEA:21608	skos:altLabel	"chalcone OMT"
RHEA:21608	skos:prefLabel	"isoliquiritigenin 2'-O-methyltransferase"
RHEA:21608	skos:altLabel	"CHMT"
REACT:R-DME-209082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further phosphorylation of APC by SGG (Drosophila melanogaster)
REACT:R-DME-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Drosophila melanogaster)
REACT:R-GGA-4551616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RPA1 (RPA70) with SUMO2,3 (Gallus gallus)
REACT:R-BTA-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Bos taurus)
REACT:R-MMU-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)
RHEA:56630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + 2 H(+) + maleylacetate => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O
RHEA:36614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 <=> (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate
RHEA:68884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + ATP + H(+) + NADPH = 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)
REACT:R-RNO-9027275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Rattus norvegicus)
EC:1.5.1.38	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FMN reductase (NADPH)"
EC:1.5.1.38	skos:altLabel	"flavin reductase P"
EC:1.5.1.38	skos:prefLabel	"FMN reductase (NADPH)"
RHEA:29828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg(2+)(in) => Mg(2+)(out)
REACT:R-DRE-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Danio rerio)
REACT:R-CEL-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Caenorhabditis elegans)
RHEA:17283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-ectoine => (2S)-4-acetamido-2-aminobutanoate
REACT:R-RNO-416929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PGF2a (Rattus norvegicus)
EC:3.6.5.5	skos:prefLabel	"dynamin GTPase"
EC:3.6.5.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dynamin GTPase"
REACT:R-SSC-5654684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR4 (Sus scrofa)
REACT:R-RNO-5654701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
REACT:R-RNO-140777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Rattus norvegicus)
RHEA:51738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => L-lysyl-[protein] + S-adenosyl-L-methionine
REACT:R-CEL-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
REACT:R-RNO-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Rattus norvegicus)
RHEA:16299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)
REACT:R-BTA-8938121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds CTSK (Bos taurus)
RHEA:59252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA
RHEA:13040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + H2O <=> ITP + NH4(+)
GO:0030793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-demethylstaurosporine O-methyltransferase activity
GO:0030793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	staurosporine synthase activity
GO:0030793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity
GO:0030793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity
RHEA:13913	skos:prefLabel	"threonine racemase"
RHEA:13913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"threonine racemase"
RHEA:13913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine = D-threonine
REACT:R-SSC-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)
RHEA:41697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate
REACT:R-MMU-4724279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Mus musculus)
REACT:R-GGA-178208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF2 (Gallus gallus)
REACT:R-GGA-5686578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates ABL1 (Gallus gallus)
REACT:R-HSA-114552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate G12/13 (Homo sapiens)
RHEA:58817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
RHEA:35833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-dehydrokanamycin A + CO2 + NH4(+) + succinate => 2-oxoglutarate + kanamycin B + O2
RHEA:14526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + beta-cyclopiazonate => AH2 + alpha-cyclopiazonate
RHEA:66211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-8-hydroxynonanoyl-CoA + O2 <=> (2E,8R)-8-hydroxynonenoyl-CoA + H2O2
REACT:R-HSA-190408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2b (Homo sapiens)
RHEA:12468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenacoside A + H2O = 26-desgluco-avenacoside A + D-glucose
REACT:R-HSA-4754181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me2K5-histone H3 (Homo sapiens)
RHEA:44801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) => 2-demethylmenaquinol-6 + CO2 + diphosphate
RHEA:53585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D2 => 7-oxoresolvin D2 + H(+) + NADH
RHEA:53914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein] => butanoyl-CoA + L-lysyl-[protein]
REACT:R-DDI-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Dictyostelium discoideum)
REACT:R-BTA-5696457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDH2 dehydrogenates 3HBA (Bos taurus)
RHEA:18754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + NADP(+) => [protein]-disulfide + H(+) + NADPH
RHEA:53838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine
REACT:R-BTA-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)
REACT:R-CFA-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Canis familiaris)
REACT:R-DDI-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Dictyostelium discoideum)
GO:0016428	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate cytosine 5-methyltransferase activity
GO:0016428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (cytosine-5-)-methyltransferase activity
GO:0016428	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer RNA cytosine 5-methyltransferase activity
GO:0016428	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity
REACT:R-SSC-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Sus scrofa)
REACT:R-DRE-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Danio rerio)
RHEA:29577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine(out) + Na(+)(out) => L-serine(in) + Na(+)(in)
REACT:R-CEL-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Caenorhabditis elegans)
RHEA:67703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)
RHEA:45557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine
RHEA:25199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + phosphate => 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O
REACT:R-DME-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Drosophila melanogaster)
REACT:R-HSA-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Homo sapiens)
REACT:R-HSA-2176417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7:NEDD4L complex translocates to the cytosol (Homo sapiens)
REACT:R-DME-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Drosophila melanogaster)
REACT:R-DRE-83656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Danio rerio)
RHEA:50752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 naphthalene-1,2,4,8-tetrol + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O
REACT:R-MMU-975311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Mus musculus)
RHEA:58861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-5205663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)
REACT:R-DME-2176445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD2 (Drosophila melanogaster)
REACT:R-HSA-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Homo sapiens)
REACT:R-RNO-8873850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD5 binds DCA, LCA (Rattus norvegicus)
RHEA:10835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)
RHEA:19980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + L-tyrosine methyl ester <=> adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate
REACT:R-MTU-868622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucose is transferred from UDP-glucose onto glucose-6-phosphate (Mycobacterium tuberculosis)
REACT:R-HSA-162721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)
RHEA:46197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyltryptamine => acetate + tryptamine
RHEA:71295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)
REACT:R-MMU-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Mus musculus)
RHEA:24017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-epivellosimine + acetyl-CoA => CoA + vinorine
RHEA:31391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) = all-trans-4,4'-diapolycopene + 4 FADH2
REACT:R-GGA-964800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuromedin-U receptors bind neuromedins U, S (Gallus gallus)
REACT:R-DRE-5634750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Danio rerio)
REACT:R-PFA-5244692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)
RHEA:41139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)
REACT:R-HSA-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Homo sapiens)
REACT:R-CFA-2168883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin:Hemoglobin binds CD163 (Canis familiaris)
RHEA:58870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2
REACT:R-PFA-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Plasmodium falciparum)
REACT:R-DME-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Drosophila melanogaster)
REACT:R-SSC-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Sus scrofa)
RHEA:71677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-leucine(in) + H(+)(in) => glycyl-L-leucine(out) + H(+)(out)
RHEA:29375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O = adenosine + phosphate
REACT:R-SPO-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Schizosaccharomyces pombe)
RHEA:15003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-fructose + H(+) + NADPH => keto-L-sorbose + NADP(+)
RHEA:68750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] => alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein]
REACT:R-RNO-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Rattus norvegicus)
RHEA:54473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate
REACT:R-GGA-9638120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU4 hydrolyses Neu5Ac from glycoconjugates (Gallus gallus)
REACT:R-HSA-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)
REACT:R-RNO-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Rattus norvegicus)
REACT:R-BTA-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Bos taurus)
REACT:R-HSA-5654514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds FGFR1c (Homo sapiens)
REACT:R-SSC-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Sus scrofa)
RHEA:56123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)
RHEA:72840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + CoA(in) => ADP(in) + CoA(out)
REACT:R-MMU-5654667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)
RHEA:65812	skos:prefLabel	"tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase"
RHEA:65812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase"
RHEA:65812	skos:altLabel	"tRNA 2-(methylsulfanyl)-N(6)-dimethylallyladenosine(37) hydroxylase"
RHEA:65812	skos:altLabel	"tRNA 2-methylthio-N(6)-isopentenyl adenosine(37) hydroxylase"
RHEA:65812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 = A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA
REACT:R-HSA-6810724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3 binds the bacterial surface (Homo sapiens)
REACT:R-BTA-9626848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Bos taurus)
RHEA:64070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenyl-1,2-propanedione + H(+) + NADH => (R)-phenylacetylcarbinol + NAD(+)
REACT:R-CEL-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Caenorhabditis elegans)
GO:0008660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity
GO:0008660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-aminocyclopropane carboxylic acid deaminase activity
GO:0008660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACC deaminase activity
GO:0008660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate deaminase activity
GO:0008660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)
REACT:R-HSA-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Homo sapiens)
REACT:R-SSC-5684862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Sus scrofa)
REACT:R-HSA-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Homo sapiens)
RHEA:20961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate
REACT:R-HSA-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Homo sapiens)
REACT:R-DRE-199404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40L binds CD40 (Danio rerio)
RHEA:44327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-butyrylglycerol + H2O <=> butanoate + glycerol + H(+)
REACT:R-HSA-199863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate NR4A1 (NUR77) (Homo sapiens)
REACT:R-DRE-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
REACT:R-HSA-9733292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind pramlintide (Homo sapiens)
REACT:R-DRE-265424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Danio rerio)
RHEA:33299	skos:altLabel	"[eIF-5A]-deoxyhypusine synthase"
RHEA:33299	skos:altLabel	"spermidine dehydrogenase"
RHEA:33299	skos:altLabel	"(4-aminobutyl)lysine synthase"
RHEA:33299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
RHEA:33299	skos:prefLabel	"deoxyhypusine synthase"
RHEA:33299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyhypusine synthase"
REACT:R-BTA-5635842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3 phosphorylates GLI (Bos taurus)
REACT:R-XTR-8866551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR binds components of the ERAD machinery for ubiquitination and degradation (Xenopus tropicalis)
REACT:R-CFA-9717206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Canis familiaris)
RHEA:71570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphomethyl-dUMP in DNA + L-serine <=> 5-O-(L-seryl)-dTMP in DNA + phosphate
REACT:R-RNO-5674132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Rattus norvegicus)
REACT:R-XTR-6784006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Xenopus tropicalis)
RHEA:31783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tuberculosinyl diphosphate = diphosphate + tuberculosinol
RHEA:17559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + N-malonylanthranilate => anthranilate + malonyl-CoA
REACT:R-GGA-4568914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of BLM with SUMO2,3 (Gallus gallus)
REACT:R-XTR-2685505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPCN1/2 transport lysosomal Ca2+ to cytosol  (Xenopus tropicalis)
RHEA:37312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-glutamine(out) + H2O => ADP + glycyl-L-glutamine(in) + H(+) + phosphate
RHEA:42880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermine = H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine
RHEA:22625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxy-2-oxopentanoate => acetaldehyde + pyruvate
RHEA:69433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine => 3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine
RHEA:33314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + hydroxylamine + NH4(+) <=> 2 AH2 + H(+) + H2O + N2
REACT:R-HSA-9021950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds MEF2C gene promoter (Homo sapiens)
REACT:R-SSC-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Sus scrofa)
REACT:R-XTR-3296304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR31 is a receptor for 12(S)-HETE (Xenopus tropicalis)
REACT:R-SSC-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Sus scrofa)
REACT:R-HSA-1655830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2) (Homo sapiens)
REACT:R-RNO-873926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNGR (Rattus norvegicus)
REACT:R-RNO-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Rattus norvegicus)
RHEA:67332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH
RHEA:28402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A
RHEA:36016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DDI-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Dictyostelium discoideum)
RHEA:10671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)
REACT:R-RNO-174447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation on the C-strand of the telomere (Rattus norvegicus)
REACT:R-SSC-9634846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNTL (BMAL1) (Sus scrofa)
RHEA:64599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)
GO:0015196	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	valine/tyrosine/tryptophan permease activity
GO:0015196	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-tryptophan transporter activity
GO:0015196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan permease activity
GO:0015196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Homo sapiens)
GO:0015196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan transmembrane transporter activity
REACT:R-HSA-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Homo sapiens)
REACT:R-CFA-741411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates NEMO (Canis familiaris)
REACT:R-RNO-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Rattus norvegicus)
REACT:R-CFA-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Canis familiaris)
REACT:R-RNO-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Rattus norvegicus)
REACT:R-BTA-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Bos taurus)
RHEA:68404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-iso(homo)2citrate + NAD(+) = 2-oxoheptanedioate + CO2 + NADH
RHEA:21182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + indole-3-acetyl-1D-myo-inositol => 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol
REACT:R-DME-4551451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Drosophila melanogaster)
RHEA:60954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferulate + S-adenosyl-L-methionine
REACT:R-DDI-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Dictyostelium discoideum)
REACT:R-GGA-8858252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDLBP binds HDL (Gallus gallus)
REACT:R-GGA-2028724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind YAP1 (Gallus gallus)
REACT:R-SSC-211207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fragments of DFF45 dissociate from  DFF40 (Sus scrofa)
REACT:R-GGA-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
RHEA:50605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]
RHEA:52930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 GMP + 2 H(+) => 3',3'-c-di-GMP + 2 H2O
REACT:R-SPO-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Schizosaccharomyces pombe)
REACT:R-SSC-202344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ZAP-70 to phosphorylated ITAMs (Sus scrofa)
REACT:R-MMU-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Mus musculus)
REACT:R-MMU-9710354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds cardiolipin (Mus musculus)
REACT:R-HSA-975139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Homo sapiens)
REACT:R-MMU-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Mus musculus)
REACT:R-DME-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Drosophila melanogaster)
RHEA:10817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside => L-fucose + methyl beta-D-galactoside
REACT:R-DRE-2530501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTA:FNTB transfers FARN to GNGT1 (Danio rerio)
REACT:R-BTA-174171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A with the APC/C (Bos taurus)
EC:3.4.13.18	skos:altLabel	"prolyl dipeptidase"
EC:3.4.13.18	skos:altLabel	"N(2)-beta-alanylarginine dipeptidase"
EC:3.4.13.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytosol non-specific dipeptidase"
EC:3.4.13.18	skos:altLabel	"Pro-X dipeptidase"
EC:3.4.13.18	skos:prefLabel	"cytosol non-specific dipeptidase"
EC:3.4.13.18	skos:altLabel	"glycyl-leucine dipeptidase"
EC:3.4.13.18	skos:altLabel	"glycyl-glycine dipeptidase"
EC:3.4.13.18	skos:altLabel	"prolylglycine dipeptidase"
EC:3.4.13.18	skos:altLabel	"peptidase A"
EC:3.4.13.18	skos:altLabel	"prolinase"
GO:0051433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 domain binding
RHEA:12414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + phosphate => (2R)-3-phosphoglycerate + H2O
RHEA:41852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:12162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-2-deoxy-D-gluconate + H(+) + NADH => 2-deoxy-D-gluconate + NAD(+)
RHEA:31466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crocetin + UDP-alpha-D-glucose <=> beta-D-glucosyl crocetin + UDP
RHEA:31472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP
EC:1.2.1.25	skos:altLabel	"branched-chain alpha-keto acid dehydrogenase complex"
EC:1.2.1.25	skos:prefLabel	"branched-chain alpha-keto acid dehydrogenase system"
EC:1.2.1.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"branched-chain alpha-keto acid dehydrogenase system"
EC:1.2.1.25	skos:altLabel	"2-oxoisovalerate dehydrogenase (acylating)"
REACT:R-CEL-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Caenorhabditis elegans)
RHEA:33925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+) => (1R,4R)-5-oxo-1,2-campholide
REACT:R-CFA-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Canis familiaris)
REACT:R-RNO-5686475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Rattus norvegicus)
REACT:R-CFA-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Canis familiaris)
GO:0047563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-HBA-2-hydroxylase activity
GO:0047563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate 2-monooxygenase activity
GO:0047563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)
GO:0047563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate 2-hydroxylase activity
REACT:R-GGA-4570485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO3 (Gallus gallus)
REACT:R-CFA-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Canis familiaris)
RHEA:27361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + S-adenosyl-L-methionine = chloromethane + S-adenosyl-L-homocysteine
REACT:R-CFA-9013021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOB (Canis familiaris)
REACT:R-DME-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Drosophila melanogaster)
RHEA:57147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)
EC:3.2.1.4	skos:altLabel	"endo-1,4-beta-D-glucanohydrolase"
EC:3.2.1.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellulase"
EC:3.2.1.4	skos:altLabel	"beta-1,4-glucanase"
EC:3.2.1.4	skos:altLabel	"endoglucanase"
EC:3.2.1.4	skos:altLabel	"carboxymethyl cellulase"
EC:3.2.1.4	skos:prefLabel	"cellulase"
EC:3.2.1.4	skos:altLabel	"beta-1,4-endoglucan hydrolase"
EC:3.2.1.4	skos:altLabel	"endo-1,4-beta-D-glucanase"
EC:3.2.1.4	skos:altLabel	"endo-1,4-beta-glucanase"
EC:3.2.1.4	skos:altLabel	"celludextrinase"
EC:3.2.1.4	skos:altLabel	"avicelase"
RHEA:45382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine
REACT:R-GGA-5682769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI2 binds ADAM22,23 (Gallus gallus)
RHEA:61607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-dithiol + [DsbB protein]-disulfide <=> [DsbA protein]-disulfide + [DsbB protein]-dithiol
RHEA:23498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-pentanoyl-CoA + acetate => 5-hydroxypentanoate + acetyl-CoA
RHEA:44177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-diacyl-sn-glycerol + H2O => 3-acyl-sn-glycerol + a fatty acid + H(+)
REACT:R-RNO-2395340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxyallysine by LOX (Rattus norvegicus)
REACT:R-MMU-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Mus musculus)
RHEA:70090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol + o-quinone methide <=> hydroxyclavatol methyl ether
REACT:R-BTA-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Bos taurus)
GO:0102834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity
RHEA:24634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + 3 NADPH + nitrite => 2 H2O + 3 NADP(+) + NH4(+)
REACT:R-SCE-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)
RHEA:21000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrogallol hydroxytransferase"
RHEA:21000	skos:altLabel	"pyrogallol hydroxyltransferase"
RHEA:21000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene
RHEA:21000	skos:altLabel	"Transhydroxylase"
RHEA:21000	skos:prefLabel	"pyrogallol hydroxytransferase"
RHEA:68420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-(homo)3aconitate + H2O = (2R,3S)-iso(homo)3citrate
RHEA:37686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
RHEA:70801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(out) + L-ornithine(in) => L-lysine(in) + L-ornithine(out)
REACT:R-HSA-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Homo sapiens)
RHEA:70538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)
GO:0033040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sour taste receptor activity
GO:0102200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)
GO:0102200	skos:prefLabel	"N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D"
GO:0102200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity
GO:0102200	skos:altLabel	"N-acyl phosphatidylethanolamine phospholipase D"
GO:0102200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D"
GO:0102200	skos:altLabel	"anandamide-generating phospholipase D"
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetylornithine transaminase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2-acetylornithine 5-aminotransferase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2-acetylornithine 5-transaminase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylornithine 5-aminotransferase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylornithine delta-transaminase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinylornithine aminotransferase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylornithine-delta-transaminase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylornithine aminotransferase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetylornithine aminotransferase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(2)-acetylornithine 5-transaminase activity
GO:0003992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACOAT activity
REACT:R-RNO-9014295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GAPs stimulate RAC2 GTPase activity (Rattus norvegicus)
RHEA:14276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + spermidine <=> 4-aminobutanal + AH2 + propane-1,3-diamine
RHEA:44514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
REACT:R-DRE-6799179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Danio rerio)
RHEA:31156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADH
REACT:R-SSC-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Sus scrofa)
REACT:R-RNO-9731613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)
REACT:R-HSA-2046180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSPG is secreted from the cell (Homo sapiens)
RHEA:46806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine => a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine
RHEA:32509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-3-isopropenylheptanoate + H(+) => 4-isopropenyl-7-methyloxepan-2-one + H2O
REACT:R-CFA-416698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA5A binds to PLXNB3 (Canis familiaris)
REACT:R-DME-5577213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)
RHEA:18881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + histamine + L-glutamate = ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate
RHEA:18881	skos:altLabel	"gamma-GHA synthetase"
RHEA:18881	skos:prefLabel	"gamma-glutamylhistamine synthase"
RHEA:18881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-glutamylhistamine synthase"
REACT:R-HSA-9636304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mce3E binds MAPK3 (Homo sapiens)
EC:3.2.1.137	skos:prefLabel	"mannan exo-1,2-1,6-alpha-mannosidase"
EC:3.2.1.137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannan exo-1,2-1,6-alpha-mannosidase"
REACT:R-SPO-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Schizosaccharomyces pombe)
REACT:R-MMU-9627056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procaspase 9 forms dimer (Mus musculus)
REACT:R-HSA-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Homo sapiens)
REACT:R-XTR-9638046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY3:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)
RHEA:49202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate => D-mannose 6-phosphate + H2O + phosphoenolpyruvate
REACT:R-PFA-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Plasmodium falciparum)
REACT:R-RNO-4641147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DACT1 binds DVL2 (Rattus norvegicus)
GO:0000062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acyl-coenzyme A binding
GO:0000062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acyl-CoA binding
GO:0000062	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fatty-acyl binding
REACT:R-HSA-380177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)
REACT:R-RNO-4615987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO2,3 (Rattus norvegicus)
RHEA:59167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]
REACT:R-SSC-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Sus scrofa)
REACT:R-XTR-9731632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)
REACT:R-DRE-8942575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Danio rerio)
REACT:R-HSA-8983307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL15RA (Homo sapiens)
RHEA:62386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + 2 H(+) => cyclic (2R)-2,3-bisphosphoglycerate + H2O
REACT:R-GGA-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Gallus gallus)
REACT:R-RNO-380869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked dopamine loaded synaptic vesicle (Rattus norvegicus)
RHEA:61583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) <=> (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH
GO:0043214	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled bacteriocin transmembrane transporter activity
GO:0043214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type bacteriocin transporter activity
GO:0043214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type bacteriocin transmembrane transporter activity
GO:0043214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacteriocin ABC transporter
GO:0103010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming)
REACT:R-MMU-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Mus musculus)
REACT:R-RNO-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Rattus norvegicus)
RHEA:67317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine => (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine
RHEA:36680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-alpha-D-allose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH
RHEA:36181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline
REACT:R-BTA-352379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Bos taurus)
RHEA:63498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrobenzyl alcohol + NADP(+) => 4-nitrobenzaldehyde + H(+) + NADPH
EC:3.4.21.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thrombin"
EC:3.4.21.5	skos:altLabel	"fibrinogenase"
EC:3.4.21.5	skos:prefLabel	"thrombin"
REACT:R-BTA-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Bos taurus)
RHEA:22445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferol + NADP(+) => (E)-coniferaldehyde + H(+) + NADPH
RHEA:59745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]
REACT:R-RNO-450690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Rattus norvegicus)
REACT:R-SSC-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Sus scrofa)
RHEA:52210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-coumaroyl-CoA synthetase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumarate-CoA ligase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-coumaryl coenzyme A synthetase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-coumaryl-CoA synthetase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-coumaryl-CoA ligase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-coumaroyl-CoA synthase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxycinnamoyl CoA synthetase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4CL
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxycinnamate:CoA ligase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-coumaryl-CoA synthetase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxycinnamoyl coenzyme A synthetase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-coumaroyl CoA ligase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-coumarate:coenzyme A ligase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feruloyl CoA ligase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-coumarate:CoA ligase (AMP-forming)
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feruloyl coenzyme A synthetase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumarate:CoA ligase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caffeolyl coenzyme A synthetase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sinapoyl coenzyme A synthetase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumarate-CoA synthetase activity
GO:0016207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxycinnamic acid:CoA ligase activity
REACT:R-PFA-5690250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Plasmodium falciparum)
REACT:R-CFA-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Canis familiaris)
REACT:R-BTA-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Bos taurus)
REACT:R-MMU-429016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 is phosphorylated by MAPKAP2 (Mus musculus)
REACT:R-HSA-140870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Homo sapiens)
REACT:R-HSA-9023632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
REACT:R-XTR-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Xenopus tropicalis)
REACT:R-HSA-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Homo sapiens)
RHEA:39867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)
REACT:R-DRE-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Danio rerio)
RHEA:35674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-5'-oxoaverantin + H(+) <=> (1'S,5'S)-averufin + H2O
REACT:R-XTR-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Xenopus tropicalis)
REACT:R-SSC-5687123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S115 MAPKAPK5 translocates to the cytosol (Sus scrofa)
RHEA:26338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + S-methyl-L-methionine => H(+) + 2 L-methionine
GO:0034868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity
RHEA:61302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + dihydroxyacetone phosphate => 5-deoxy-D-ribulose 1-phosphate
REACT:R-SSC-83660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-anchored TNF-α binds TNFR1 (Sus scrofa)
EC:4.2.2.22	skos:altLabel	"exopectate-lyase"
EC:4.2.2.22	skos:prefLabel	"pectate trisaccharide-lyase"
EC:4.2.2.22	skos:altLabel	"pectate lyase A"
EC:4.2.2.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pectate trisaccharide-lyase"
RHEA:60625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine
REACT:R-SSC-6807053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SC5D desaturates LTHSOL to 7-dehydroCHOL (Sus scrofa)
REACT:R-DRE-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Danio rerio)
RHEA:39342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)
REACT:R-DDI-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Dictyostelium discoideum)
REACT:R-GGA-3465448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)
REACT:R-BTA-2028583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS2 (Bos taurus)
REACT:R-DME-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Drosophila melanogaster)
REACT:R-CFA-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)
REACT:R-RNO-8866551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR binds components of the ERAD machinery for ubiquitination and degradation (Rattus norvegicus)
RHEA:23646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Canis familiaris)
RHEA:12105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP => 7,8-dihydrofolate + dTMP
RHEA:48245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 => CMP + ganglioside GM1b + H(+)
REACT:R-GGA-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Gallus gallus)
REACT:R-CFA-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Canis familiaris)
GO:0033449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUU codon-amino acid adaptor activity
GO:0033449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTT codon-amino acid adaptor activity
GO:0033449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine tRNA
REACT:R-DRE-9014456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOG (Danio rerio)
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	12S-lipoxygenase activity
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTA4 synthase activity
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arachidonate 12-lipoxygenase"
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta12-lipoxygenase activity
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonate:oxygen 12-oxidoreductase activity
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	12Delta-lipoxygenase activity
GO:0004052	skos:prefLabel	"arachidonate 12-lipoxygenase"
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	12-lipoxygenase activity
GO:0004052	skos:altLabel	"12-lipoxygenase"
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C-12 lipoxygenase activity
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonate 12(S)-lipoxygenase activity
GO:0004052	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	leukotriene A4 synthase
RHEA:68030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + urate => 6,8-dihydroxypurine + H2O + O2
REACT:R-CFA-983138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC heterotrimer to ER exit site (Canis familiaris)
REACT:R-HSA-389354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Vav1 (Homo sapiens)
REACT:R-DRE-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Danio rerio)
REACT:R-BTA-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Bos taurus)
RHEA:61524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 = (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate
REACT:R-SSC-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Sus scrofa)
REACT:R-BTA-8939201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR dimerizes (Bos taurus)
REACT:R-DRE-8853737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Danio rerio)
RHEA:24141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
GO:0047650	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkyldihydroxyacetone kinase activity
GO:0047650	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:O-alkylglycerone phosphotransferase activity
GO:0047650	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkyldihydroxyacetone kinase (phosphorylating)
GO:0047650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylglycerone kinase activity
REACT:R-MMU-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Mus musculus)
REACT:R-CFA-6798374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DYRK2 phosphorylates TP53 (Canis familiaris)
REACT:R-XTR-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Xenopus tropicalis)
REACT:R-SSC-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Sus scrofa)
RHEA:50481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]
REACT:R-XTR-5610723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind SUFU (Xenopus tropicalis)
RHEA:42778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine => adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine
REACT:R-XTR-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)
REACT:R-HSA-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Homo sapiens)
REACT:R-SCE-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Saccharomyces cerevisiae)
RHEA:72977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+) => 2 ATP + 2 indole-3-pyruvate
REACT:R-SSC-3134953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 or DHX9 binds MyD88 (Sus scrofa)
REACT:R-HSA-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)
REACT:R-GGA-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Gallus gallus)
REACT:R-SPO-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Schizosaccharomyces pombe)
REACT:R-CEL-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Caenorhabditis elegans)
REACT:R-MMU-389487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 2 receptor can bind orexin-B neuropeptide (Mus musculus)
REACT:R-SCE-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)
RHEA:63350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-cysteinyl-[protein]
RHEA:57576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]
RHEA:31900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]
RHEA:33384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + UDP-N-acetyl-alpha-D-glucosamine => (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP
RHEA:36621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine => 2-hydroxydocosanoyl-CoA + sphinganine
REACT:R-RNO-5229010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-27 of histone H3 (H3R26) (Rattus norvegicus)
RHEA:68648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-cysteine = H(+) + hydrogen sulfide + L-lanthionine
REACT:R-HSA-9727919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins (Homo sapiens)
REACT:R-BTA-202541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
RHEA:46385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoate + 2 H(+) + NADH => decanal + H2O + NAD(+)
REACT:R-DME-432424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JET binds phosphorylated nuclear TIM, facilitating its ubiquitination (Drosophila melanogaster)
REACT:R-CEL-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Caenorhabditis elegans)
RHEA:67595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end CoA-ribonucleoside in mRNA + H2O <=> (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)
RHEA:21149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose => 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP
REACT:R-BTA-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)
REACT:R-CEL-5665802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Caenorhabditis elegans)
REACT:R-CFA-446870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated TRAF6 binds the TAK1 complex (Canis familiaris)
REACT:R-RNO-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Rattus norvegicus)
REACT:R-XTR-201712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin:TCF associates with BCL9 and PYGO (Xenopus tropicalis)
REACT:R-HSA-8987039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL20RA (Homo sapiens)
RHEA:51276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-DRE-429016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 is phosphorylated by MAPKAP2 (Danio rerio)
REACT:R-RNO-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)
REACT:R-DRE-9700175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates SHC1 (Danio rerio)
RHEA:29263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out)
REACT:R-CEL-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Caenorhabditis elegans)
REACT:R-HSA-5211340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anthrax lef cleaves target cell MAP2K1 (MEK1) (Homo sapiens)
RHEA:71030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-phenylalanine(out) <=> L-glutamine(out) + L-phenylalanine(in)
REACT:R-DME-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Drosophila melanogaster)
REACT:R-DRE-374214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CXCR4 and 7 bind CXCL12 ligand (Danio rerio)
REACT:R-HSA-8950210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 dissociates from Interleukin-27 receptor (Homo sapiens)
REACT:R-RNO-450466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1:mRNA complex is destroyed (Rattus norvegicus)
REACT:R-XTR-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)
REACT:R-GGA-8854051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL18 ubiquitinates FBXL7 (Gallus gallus)
REACT:R-RNO-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
REACT:R-DRE-5591086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA5 binds activated protein C (Danio rerio)
RHEA:18966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylbilane => H2O + uroporphyrinogen III
REACT:R-SSC-5654673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Sus scrofa)
REACT:R-XTR-9027624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DHA to 7-HDHA (Xenopus tropicalis)
RHEA:63603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neocasomorphin <=> L-isoleucine + neocasomorphin-(1-5)
REACT:R-RNO-1606807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Rattus norvegicus)
RHEA:60193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate
RHEA:21668	skos:prefLabel	"ABC-type glycerol 3-phosphate transporter"
RHEA:21668	skos:altLabel	"glycerol-3-phosphate-transporting ATPase"
RHEA:21668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sn-glycerol 3-phosphate(out) = ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)
RHEA:21668	skos:altLabel	"glycerol-3-phosphate ABC transporter"
RHEA:21668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type glycerol 3-phosphate transporter"
RHEA:17203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-L-arabinonate
REACT:R-XTR-198513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Xenopus tropicalis)
REACT:R-DDI-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Dictyostelium discoideum)
RHEA:65667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + 4 Na(+)(out) <=> citrate(in) + 4 Na(+)(in)
RHEA:43483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-XTR-204169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP dephosphorylates p-lipo-PDH (Xenopus tropicalis)
RHEA:29545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
REACT:R-RNO-1482545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)
REACT:R-RNO-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Rattus norvegicus)
REACT:R-GGA-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Gallus gallus)
REACT:R-RNO-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Rattus norvegicus)
REACT:R-XTR-9756169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)
REACT:R-XTR-2408524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Xenopus tropicalis)
RHEA:50658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)ethylmaleate + H2O => 3-(2-methylsulfanyl)ethylmalate
RHEA:34459	skos:prefLabel	"sclareol synthase"
RHEA:34459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sclareol synthase"
RHEA:34459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycopalyl diphosphate + H2O = diphosphate + sclareol
RHEA:13958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H2O + O2 + 4 sulfur => 6 H(+) + 2 hydrogen sulfide + 2 sulfite
REACT:R-MMU-199518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3d-complexed antigen binds to complement receptor (Mus musculus)
REACT:R-RNO-75879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Rattus norvegicus)
REACT:R-HSA-5694433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 binds PREB (Homo sapiens)
REACT:R-DRE-266315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + spherical HDL <=> LCAT:spherical HDL complex (Danio rerio)
REACT:R-SCE-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Saccharomyces cerevisiae)
REACT:R-CFA-914182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)
REACT:R-SCE-8869607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NAR to yield NAMN (Saccharomyces cerevisiae)
REACT:R-MMU-9645481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIFA oligomerization (Mus musculus)
REACT:R-DME-5654515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds HS (Drosophila melanogaster)
REACT:R-XTR-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Xenopus tropicalis)
RHEA:72445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + AMP + H(+) => (E)-feruloyl-AMP + CoA
REACT:R-DME-2022056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPG and CSPG translocate to the lysosome for degradation (Drosophila melanogaster)
REACT:R-SSC-9757688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDN (Sus scrofa)
GO:0050282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine 2-dehydrogenase activity
GO:0050282	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine:NAD+ 2-oxidoreductase (deaminating)
GO:0050282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine dehydrogenase activity
GO:0050282	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine:NAD oxidoreductase (deaminating) activity
RHEA:55415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + GTP <=> [phosphate](n+1) + GDP
RHEA:21626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + 2 H(+) + NADPH => FMNH2 + NADP(+)
RHEA:21757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylisoipecoside + H2O => dopamine + secologanin
RHEA:58415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]
REACT:R-DDI-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Dictyostelium discoideum)
REACT:R-HSA-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Homo sapiens)
RHEA:23782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA
RHEA:72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic CMP + H2O => CMP + H(+)
GO:0034326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyltransferase activity
REACT:R-SSC-5691154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HFE binds TFRC dimer (Sus scrofa)
REACT:R-GGA-1236967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alkalization of the phagosomal lumen by NOX2 (Gallus gallus)
REACT:R-RNO-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Rattus norvegicus)
RHEA:46958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:40390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
RHEA:23891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine <=> [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate
RHEA:16686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,poly-cis-dolichol + hexadecanoyl-CoA => a dolichyl hexadecanoate + CoA
RHEA:14370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phosphoglycolate + H2O => glycolate + phosphate
REACT:R-MMU-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Mus musculus)
RHEA:60924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + L-lysyl-[protein] + succinate
REACT:R-DME-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Drosophila melanogaster)
REACT:R-RNO-1483089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is converted to PS by PTDSS2 (Rattus norvegicus)
GO:0090632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity
GO:0090632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-Neu5Gc synthetase activity
REACT:R-SSC-380076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 1 (NK1) binds to substance P (Sus scrofa)
REACT:R-CEL-193060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
REACT:R-PFA-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Plasmodium falciparum)
REACT:R-SSC-9013157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the plasma membrane (Sus scrofa)
GO:0008753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase
GO:0008753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH dehydrogenase (quinone) activity
GO:0008753	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADPH oxidase
GO:0008753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:(quinone-acceptor) oxidoreductase
EC:1.18.96.-	skos:prefLabel	"With other, known, acceptors"
EC:1.18.96.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
REACT:R-XTR-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Xenopus tropicalis)
REACT:R-HSA-8938053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds the SERPINB13 gene promoter (Homo sapiens)
REACT:R-DME-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Drosophila melanogaster)
REACT:R-MMU-6793666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the nucleus (Mus musculus)
REACT:R-RNO-77609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of APOBEC-1 to form editosome (Rattus norvegicus)
REACT:R-HSA-1989757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FADS1 (Homo sapiens)
REACT:R-RNO-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Rattus norvegicus)
RHEA:59292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O = D-galactose + N-octadecanoylsphing-4-enine
REACT:R-DDI-917693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESCRT Disassembly (Dictyostelium discoideum)
RHEA:44426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acyl-heptadecasphing-4-enine => a fatty acyl-CoA + heptadecasphing-4-enine
REACT:R-HSA-209815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is monoiodinated (Homo sapiens)
RHEA:21341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 => 2 vanillin
RHEA:16348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate
RHEA:49758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + proviolacein => H(+) + O2 + protoviolaceinate
RHEA:67607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-methyl-dATP <=> diphosphate + H(+) + N(6)-methyl-dAMP
REACT:R-HSA-5690988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
REACT:R-MMU-2046222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Mus musculus)
REACT:R-CEL-373734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin interacts with Podocin (Caenorhabditis elegans)
RHEA:16778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + K(+)(out) => ADP + H(+) + K(+)(in) + phosphate
REACT:R-DME-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Drosophila melanogaster)
REACT:R-HSA-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Homo sapiens)
RHEA:44758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine
RHEA:63547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kinetensin <=> kinetensin-(1-8) + L-leucine
RHEA:37018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-SSC-4086200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin matrix protein 1 binds integrin alphaVbeta3 (Sus scrofa)
RHEA:65642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine => (4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA
RHEA:33671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O = 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2
RHEA:51336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate
RHEA:24155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + ATP <=> 3'-phosphoadenylyl sulfate + ADP + H(+)
REACT:R-CFA-202500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of IKK complex (Canis familiaris)
REACT:R-SSC-5687090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6 phosphorylates NCOA3 (Sus scrofa)
RHEA:38403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)
REACT:R-HSA-1791121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of XBP1(S) (Homo sapiens)
REACT:R-DRE-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Danio rerio)
REACT:R-DME-1250264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP binds reduced thioredoxin (Drosophila melanogaster)
REACT:R-GGA-909730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of INFAR1 by TYK2 (Gallus gallus)
REACT:R-HSA-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Homo sapiens)
REACT:R-SCE-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Saccharomyces cerevisiae)
RHEA:40790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetracosanoyl-CoA <=> CoA + H(+) + tetracosanoate
REACT:R-RNO-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Rattus norvegicus)
REACT:R-SPO-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Schizosaccharomyces pombe)
RHEA:69677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + beta-D-glucose => eriodictyol-7-O-beta-D-glucoside + H2O
RHEA:46848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) = 5alpha-cholest-8-en-3-one + CO2 + NADPH
REACT:R-HSA-9036008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch) (Homo sapiens)
GO:0102059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis,6-cis-farnesyl pyrophosphate synthase activity
GO:0102059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neryl-diphosphate:isopentenyl-diphosphate cistransferase activity
RHEA:18455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate => [(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O
REACT:R-SSC-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Sus scrofa)
RHEA:62648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate
REACT:R-MMU-399712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Mus musculus)
RHEA:26275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-4 + S-adenosyl-L-homocysteine => Co-precorrin-3 + S-adenosyl-L-methionine
REACT:R-DME-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-RNO-388855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin-releasing hormone receptor binds PRH (Rattus norvegicus)
REACT:R-HSA-448963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of MyoD:E protein with MEF2 (Homo sapiens)
RHEA:55889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[aequorin]--dioxetanone => [excited state blue fluorescent protein] + CO2
RHEA:50713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + O2 + tetracycline => 7-chlorotetracycline + FAD + H(+) + 2 H2O
REACT:R-HSA-380574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine synaptic vesicle docking and priming (Homo sapiens)
RHEA:54817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[protein] + L-lysyl-[protein] => [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)
REACT:R-HSA-5340226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB dioxygenates NO (Homo sapiens)
RHEA:56871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA
GO:0016840	skos:prefLabel	"Carbon-nitrogen lyases"
GO:0016840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carbon-nitrogen lyases"
GO:0016840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-nitrogen lyase activity
GO:0016840	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	other carbon-nitrogen lyase activity
RHEA:10453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Mus musculus)
RHEA:47476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-tetradecenoyl-CoA = (2E)-tetradecenoyl-CoA
REACT:R-CFA-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Canis familiaris)
REACT:R-RNO-159762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)
RHEA:37383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-9679421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCD1 binds PDCD1 inhibitors (Homo sapiens)
RHEA:68134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + tetradecanoate phytyl ester => phytol + tetradecanoyl-CoA
REACT:R-DME-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Drosophila melanogaster)
REACT:R-CFA-6811412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer to the Golgi (Canis familiaris)
REACT:R-XTR-8849882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-4 bind reticulon 3 (Xenopus tropicalis)
REACT:R-CEL-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Caenorhabditis elegans)
REACT:R-GGA-3782535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Gallus gallus)
REACT:R-RNO-9627078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP9 (Rattus norvegicus)
RHEA:72391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + oxalate(in) = 2 hydrogencarbonate(in) + oxalate(out)
REACT:R-XTR-2168889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin-related Protein binds Hemoglobin (Xenopus tropicalis)
GO:1902282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential
GO:1902282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential
GO:1902282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:1902282	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential
GO:1902282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential
REACT:R-HSA-419011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectins (Homo sapiens)
RHEA:60216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate
RHEA:11277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 hydroquinone + O2 => 4 benzosemiquinone + 2 H2O
REACT:R-BTA-508308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Bos taurus)
REACT:R-SCE-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Saccharomyces cerevisiae)
RHEA:59147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate
RHEA:19786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dihydroclavaminate + O2 => clavaminate + CO2 + H2O + succinate
GO:0050023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuconate hydratase activity
GO:0050023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuconate dehydratase activity
GO:0050023	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)
GO:0050023	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fuconate hydro-lyase activity
REACT:R-SSC-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Sus scrofa)
RHEA:51359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-glutamine <=> (9Z)-octadecenoate + L-glutamine
REACT:R-CFA-6785648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEMO1 binds RHOA:GTP:DIAPH1 (Canis familiaris)
REACT:R-CFA-1297338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of ADAM and B4GALT1 With ZP3 (Canis familiaris)
REACT:R-DME-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Drosophila melanogaster)
RHEA:13688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + NADP(+) <=> 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH
REACT:R-CFA-9618378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 binds the Nup107-Nup160 complex (Canis familiaris)
RHEA:35588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + H2O => phosphate + riboflavin
EC:3.1.11.1	skos:prefLabel	"exodeoxyribonuclease I"
EC:3.1.11.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exodeoxyribonuclease I"
EC:3.1.11.1	skos:altLabel	"E.coli exonuclease I"
EC:3.1.11.1	skos:altLabel	"exonuclease I"
RHEA:18131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + 2 H(+) + NADPH => 2-oxoaldehyde + H2O + NADP(+)
REACT:R-DRE-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Danio rerio)
REACT:R-DME-170844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 is cleaved by FURIN (Drosophila melanogaster)
REACT:R-HSA-390252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)
REACT:R-DDI-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Dictyostelium discoideum)
REACT:R-DRE-5626228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The distal appendage proteins recruit TTBK2 (Danio rerio)
REACT:R-HSA-9689608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPP5 binds SARS-CoV-1 E pentamer (Homo sapiens)
GO:0044876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hercynine + 2 L-selenocysteine + O2 = 2 H2O + 2 hercynylselenocysteine
GO:0044876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hercynylselenocysteine synthase
REACT:R-MMU-2025724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Mus musculus)
REACT:R-DME-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Drosophila melanogaster)
RHEA:17858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate
REACT:R-HSA-9688832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PDCD6IP and SDCBP (Homo sapiens)
REACT:R-CFA-375340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 62 mediated neuronal gap junction communication (Canis familiaris)
REACT:R-GGA-8938867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND3,(CCND1,CCND2) binds RUNX1 (Gallus gallus)
REACT:R-GGA-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Gallus gallus)
RHEA:30215	skos:prefLabel	"nitric oxide reductase (menaquinol)"
RHEA:30215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitric oxide reductase (menaquinol)"
RHEA:30215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 2 nitric oxide = a menaquinone + H2O + nitrous oxide
RHEA:65532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-1-ol + hexanoyl-CoA = 2-methylbutyl hexanoate + CoA
REACT:R-HSA-1015699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGF3 binds the ISRE promoter elements in IFN-stimulated genes (Homo sapiens)
GO:0062187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anandamide 8,9 epoxidase activity
GO:0062187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Canis familiaris)
REACT:R-GGA-5668545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK autophosphorylates on T559 (Gallus gallus)
REACT:R-MMU-114558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate Gq (Mus musculus)
REACT:R-BTA-204850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Dok-2 (Bos taurus)
RHEA:16060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:11387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxooctadecanoate + H(+) + NADH
GO:0031628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	opioid receptor binding
RHEA:34961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) => (R)-carnitine(in)
REACT:R-MMU-5686475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Mus musculus)
REACT:R-MMU-428007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled histidine and di-peptide cotransport (Mus musculus)
REACT:R-XTR-2028735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind WWTR1 (TAZ) (Xenopus tropicalis)
GO:0004181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metallocarboxypeptidase activity
EC:1.1.1.386	skos:altLabel	"IDOLDH"
EC:1.1.1.386	skos:prefLabel	"ipsdienol dehydrogenase"
EC:1.1.1.386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ipsdienol dehydrogenase"
RHEA:36381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methylzymosterol + NADP(+) => 3-dehydro-4alpha-methylzymosterol + H(+) + NADPH
REACT:R-RNO-6810643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPPIN protein complex binds bacteria (Rattus norvegicus)
REACT:R-HSA-1912374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of NOTCH precursor to Golgi (Homo sapiens)
RHEA:59106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+) => a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate
REACT:R-HSA-9756670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EOMES and TBXT bind the POU5F1 (OCT4) gene (Homo sapiens)
REACT:R-CFA-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Canis familiaris)
RHEA:49005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADPH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)
REACT:R-HSA-9006844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21:IL21R:JAK1 binds IL2RG:JAK3 (Homo sapiens)
RHEA:40565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+) => dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2
RHEA:45184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O
RHEA:38515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)
REACT:R-DRE-9687828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-GlcNAcylation of RIPK3 (TLR4 signaling) (Danio rerio)
RHEA:40852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + FADH2
REACT:R-GGA-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Gallus gallus)
REACT:R-HSA-9761852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent TKT gene expression (Homo sapiens)
REACT:R-DME-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Drosophila melanogaster)
REACT:R-CEL-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Caenorhabditis elegans)
RHEA:23147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-D-glucosamine + NAD(+) <=> 2 H(+) + N-acetyl-D-glucosaminate + NADH
RHEA:64438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycylglycyl-L-isoleucine(in) + H(+)(in) => glycylglycyl-L-isoleucine(out) + H(+)(out)
RHEA:71862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate(out) <=> glycochenodeoxycholate(in)
RHEA:25457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + gamma-humulene
REACT:R-RNO-6814094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds ARFIP2 (Rattus norvegicus)
RHEA:22200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine
RHEA:22200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-aconitate 3-methyltransferase"
RHEA:22200	skos:prefLabel	"trans-aconitate 3-methyltransferase"
REACT:R-CEL-1592436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP9 by MMPs (Caenorhabditis elegans)
RHEA:23233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome c] + hydrazine => 4 Fe(II)-[cytochrome c] + 4 H(+) + N2
GO:0043544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoamide binding
REACT:R-MMU-1028817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Mus musculus)
REACT:R-SSC-199014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD96 binds PVR (Sus scrofa)
REACT:R-GGA-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Gallus gallus)
EC:1.1.1.350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ureidoglycolate dehydrogenase (NAD(+))"
EC:1.1.1.350	skos:prefLabel	"ureidoglycolate dehydrogenase (NAD(+))"
REACT:R-BTA-158354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Bos taurus)
REACT:R-MMU-5607740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta phosphorylates CARD9 (Mus musculus)
REACT:R-RNO-73815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)
REACT:R-RNO-917807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Rattus norvegicus)
RHEA:19165	skos:prefLabel	"diglucosyl diacylglycerol synthase (1,2-linking)"
RHEA:19165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diglucosyl diacylglycerol synthase (1,2-linking)"
RHEA:19165	skos:altLabel	"DGlcDAG synthase"
RHEA:19165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP
RHEA:19165	skos:altLabel	"MGlcDAG (1->2) glucosyltransferase"
RHEA:19165	skos:altLabel	"monoglucosyl diacylglycerol (1->2) glucosyltransferase"
REACT:R-DME-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)
RHEA:60754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + jasmolin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone
RHEA:62623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + a hydroperoxide <=> [thioredoxin]-disulfide + an alcohol + H2O
RHEA:33241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetone + CO2 + NADH => L-threonine + NAD(+)
RHEA:37765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA
REACT:R-MMU-2168887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Albumin to Hemopexin (Mus musculus)
RHEA:56665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPacetylmuramoylpentapeptide synthetase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylmuramoylpentapeptide synthetase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MurF synthetase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-MurNAc-pentapeptide synthetase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity
GO:0047480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity
REACT:R-HSA-8935988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCLN (Occludin) gene expression is stimulated by RUNX1 (Homo sapiens)
REACT:R-RNO-2022378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Rattus norvegicus)
REACT:R-RNO-445797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLK (MLCK) Active Calmodulin Binding (Rattus norvegicus)
REACT:R-DRE-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Danio rerio)
REACT:R-MMU-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Mus musculus)
GO:0003963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA cyclase activity
GO:0003963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)
GO:0003963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-3'-phosphate cyclase activity
GO:0003963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA 3'-terminal phosphate cyclase activity
REACT:R-SSC-174757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Sus scrofa)
RHEA:62777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-GGA-8854897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Gallus gallus)
REACT:R-DRE-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Danio rerio)
REACT:R-HSA-8937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
REACT:R-HSA-9760510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARP1 binds SARS-CoV-2 RNA (Homo sapiens)
RHEA:43000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate
RHEA:43000	skos:prefLabel	"pentamethylcyclopentadecatrienol synthase"
RHEA:43000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pentamethylcyclopentadecatrienol synthase"
REACT:R-MMU-5682690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 dissociates from ATG12:ATG5 (Mus musculus)
REACT:R-SCE-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-HSA-204500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CyP60 chaperones Basigin (Homo sapiens)
REACT:R-RNO-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Rattus norvegicus)
REACT:R-MMU-433099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS2 co-transports sulphate and two sodium ions (Mus musculus)
RHEA:37080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-209094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' (Drosophila melanogaster)
REACT:R-RNO-5634100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 dissociates from RXRA:PPARD:atRA (Rattus norvegicus)
RHEA:28201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH
REACT:R-HSA-5340560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion (Homo sapiens)
RHEA:22568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ascopyrone tautomerase"
RHEA:22568	skos:altLabel	"ascopyrone intramolecular oxidoreductase"
RHEA:22568	skos:altLabel	"ascopyrone isomerase"
RHEA:22568	skos:altLabel	"ascopyrone P tautomerase"
RHEA:22568	skos:prefLabel	"ascopyrone tautomerase"
RHEA:22568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascopyrone M = ascopyrone P
RHEA:22568	skos:altLabel	"APTM"
RHEA:22568	skos:altLabel	"APM tautomerase"
RHEA:22568	skos:altLabel	"1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase"
RHEA:37246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA
REACT:R-MMU-2002460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB binds Collagen chains (Mus musculus)
RHEA:43917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-388605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMC(138-176) binds MC2R (Sus scrofa)
REACT:R-DRE-374909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabolism of Noradrenaline (Danio rerio)
REACT:R-XTR-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Xenopus tropicalis)
RHEA:47056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-SPO-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Schizosaccharomyces pombe)
REACT:R-HSA-5602984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)
RHEA:39623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)
REACT:R-BTA-2028284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Bos taurus)
REACT:R-CFA-8876472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 binds CHOL (Canis familiaris)
REACT:R-XTR-1676162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Xenopus tropicalis)
REACT:R-RNO-9604328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates NOTCH4 (Rattus norvegicus)
REACT:R-SSC-5654655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PPTN11 (Sus scrofa)
RHEA:30863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate
RHEA:20055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose + H(+) + NADH => NAD(+) + ribitol
RHEA:53433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-HSA-9626832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Homo sapiens)
RHEA:28358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + FADH2
REACT:R-DRE-216048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Danio rerio)
REACT:R-SSC-170977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 is phosphorylated by active TrkA receptor (Sus scrofa)
RHEA:28035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dADP + H2O => [thioredoxin]-dithiol + ADP
RHEA:54434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2
REACT:R-SSC-9698408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates active FLT3 (Sus scrofa)
RHEA:26007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate => beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP
REACT:R-DME-8948066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-IRAK1 dissociates (Drosophila melanogaster)
RHEA:71780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate(out) + H(+)(out) => 4-methyl-2-oxopentanoate(in) + H(+)(in)
RHEA:53983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
REACT:R-HSA-5663122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds NAMPT gene (Homo sapiens)
GO:0047533	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity
GO:0047533	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate semialdehyde dehydrogenase activity
GO:0047533	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutaric semialdehyde dehydrogenase activity
GO:0047533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxovalerate dehydrogenase (NADP+) activity
REACT:R-HSA-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)
REACT:R-SSC-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Sus scrofa)
RHEA:69067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 <=> H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline
REACT:R-CFA-1168459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lyn activates ERK (Canis familiaris)
REACT:R-XTR-5694077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Xenopus tropicalis)
REACT:R-CFA-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Canis familiaris)
RHEA:32784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine betaine(out) + H2O => ADP + glycine betaine(in) + H(+) + phosphate
RHEA:71098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + pregnenolone sulfate(out) <=> 2 Na(+)(in) + pregnenolone sulfate(in)
REACT:R-GGA-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Gallus gallus)
REACT:R-SCE-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Saccharomyces cerevisiae)
REACT:R-DRE-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)
REACT:R-DRE-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Danio rerio)
RHEA:42737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine
REACT:R-RNO-351913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of TJP1 (Rattus norvegicus)
REACT:R-BTA-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Bos taurus)
REACT:R-DME-9624112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK4 (Drosophila melanogaster)
RHEA:68887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + ATP + H(+) + NADPH <=> 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)
REACT:R-BTA-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Bos taurus)
REACT:R-BTA-9611277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds P2RY12 antagonists (Bos taurus)
RHEA:47994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + NADH + NADP(+) => H(+)(in) + NAD(+) + NADPH
REACT:R-RNO-193787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Rattus norvegicus)
RHEA:29284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) + Na(+)(in) => L-alanine(out) + Na(+)(out)
RHEA:69799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophanyl-tRNA(Trp) + H2O = D-tryptophan + tRNA(Trp)
REACT:R-SSC-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Sus scrofa)
REACT:R-CEL-2059926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPHP4 protein binds LATS proteins (Caenorhabditis elegans)
RHEA:41291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4-enine
RHEA:21546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl triphosphate + ADP => (2E,6E)-farnesyl diphosphate + ATP
RHEA:10149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	blasticidin S + H(+) + H2O => deaminohydroxyblasticidin S + NH4(+)
REACT:R-CFA-77323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Canis familiaris)
GO:0008597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent protein serine/threonine phosphatase regulator activity
GO:0008597	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity
GO:0008597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of BAD by calcineurin (Homo sapiens)
REACT:R-HSA-453339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)
REACT:R-SCE-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Saccharomyces cerevisiae)
REACT:R-BTA-2213236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Bos taurus)
RHEA:63703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolate + UDP-alpha-D-glucuronate <=> mycophenolic acid O-acyl-beta-D-glucuronide + UDP
REACT:R-BTA-163096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Telomerase RNP to the Telomeric Chromosome End (Bos taurus)
RHEA:31993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sesquithujene => (2E,6E)-farnesyl diphosphate
RHEA:44533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Canis familiaris)
RHEA:50209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + NAD(+) => cortisone + H(+) + NADH
RHEA:40007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O = (+)-copalol + diphosphate
REACT:R-DDI-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Dictyostelium discoideum)
REACT:R-CFA-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Canis familiaris)
GO:0042880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate transmembrane transporter activity
REACT:R-DRE-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
REACT:R-SSC-205289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of KIT (Sus scrofa)
REACT:R-CFA-9707505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to CLEC1B dimer (Canis familiaris)
REACT:R-MMU-204871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb2 (Mus musculus)
REACT:R-BTA-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Bos taurus)
REACT:R-HSA-75187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL receptor trimers bind FADD (Homo sapiens)
REACT:R-SSC-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Sus scrofa)
RHEA:21127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
REACT:R-SSC-217258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO2:FAD:Mg2+ S-oxidises MTZ (Sus scrofa)
RHEA:18900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine
RHEA:16304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) <=> ADP-D-ribose + H(+) + nicotinamide
REACT:R-XTR-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Xenopus tropicalis)
REACT:R-MMU-4341016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Mus musculus)
RHEA:71852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate(out) => glycocholate(in)
GO:0047066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipid-hydroperoxide glutathione peroxidase activity
GO:0047066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospholipid hydroperoxide glutathione peroxidase activity
GO:0047066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peroxidation-inhibiting protein activity
GO:0047066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroperoxide glutathione peroxidase activity
REACT:R-DDI-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Dictyostelium discoideum)
REACT:R-DRE-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Danio rerio)
REACT:R-DRE-9638090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)
REACT:R-CEL-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Caenorhabditis elegans)
REACT:R-CFA-8857577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 facilitates PTK6 autophosphorylation (Canis familiaris)
REACT:R-GGA-186778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 binds to the active receptor (Gallus gallus)
REACT:R-HSA-453183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y348-SYK dissociates (Homo sapiens)
GO:0106223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	germacrene A alcohol dehydrogenase activity
GO:0106223	skos:prefLabel	"germacrene A hydroxylase"
GO:0106223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
GO:0106223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"germacrene A hydroxylase"
GO:0106223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacrene A hydroxylase activity
RHEA:25888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinolinate synthase"
RHEA:25888	skos:altLabel	"quinolinate synthetase"
RHEA:25888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate
RHEA:25888	skos:prefLabel	"quinolinate synthase"
GO:0004058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic-L-amino-acid decarboxylase activity
GO:0004058	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
GO:0004058	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tryptophan decarboxylase activity
GO:0004058	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aromatic-L-amino-acid carboxy-lyase activity
GO:0004058	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	5-hydroxytryptophan decarboxylase activity
GO:0004058	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DOPA decarboxylase activity
GO:0004058	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aromatic amino acid decarboxylase activity
GO:0004058	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydroxytryptophan decarboxylase activity
GO:0004058	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-DOPA decarboxylase activity
REACT:R-HSA-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-HSA-8940074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NMN (Homo sapiens)
REACT:R-CFA-2424252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds collagen, fibronectin, aggrecan and matrilins (Canis familiaris)
REACT:R-DRE-216045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I binds integrin alpha11beta1 (Danio rerio)
RHEA:31604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)
REACT:R-RNO-4085029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU2 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)
REACT:R-BTA-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Bos taurus)
RHEA:66162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexanoyltyramine => hexanoyl-CoA + tyramine
RHEA:69135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine + H2O + O2 <=> 5-aminopentanal + H2O2 + NH4(+)
REACT:R-BTA-8867754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
REACT:R-DME-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Drosophila melanogaster)
RHEA:13636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + putrescine <=> ADP + gamma-L-glutamylputrescine + H(+) + phosphate
RHEA:60194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2
REACT:R-DRE-5340214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB binds O2 (Danio rerio)
RHEA:24314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine => L-lysyl-[cytochrome c] + S-adenosyl-L-methionine
RHEA:32697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-car-3-ene + diphosphate => (2E)-geranyl diphosphate
GO:0030270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity
GO:0030270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylmethanofuran-tetrahydromethanopterin formyltransferase activity
GO:0030270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FTR
GO:0030270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity
GO:0030270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity
GO:0030270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity
GO:0030270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylmethanofuran:tetrahydromethanopterin formyltransferase activity
REACT:R-DRE-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Danio rerio)
RHEA:34253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-3-dehydrosphinganine + H(+) + NADPH => 1-deoxysphinganine + NADP(+)
REACT:R-XTR-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Xenopus tropicalis)
RHEA:14103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-hypusine + A + H2O => [eIF5A protein]-deoxyhypusine + AH2 + O2
REACT:R-SSC-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)
EC:3.4.24.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"atrolysin C"
EC:3.4.24.42	skos:altLabel	"hemorrhagic toxin c"
EC:3.4.24.42	skos:prefLabel	"atrolysin C"
EC:3.4.24.42	skos:altLabel	"Crotalus atrox metalloendopeptidase c"
EC:3.4.24.42	skos:altLabel	"Ht-c"
EC:2.1.4.3	skos:prefLabel	"L-arginine:L-lysine amidinotransferase"
EC:2.1.4.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arginine:L-lysine amidinotransferase"
REACT:R-CFA-174427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Canis familiaris)
RHEA:63749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan-2-N-beta-D-glucuronide
REACT:R-DME-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Drosophila melanogaster)
REACT:R-PFA-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Plasmodium falciparum)
REACT:R-DME-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Drosophila melanogaster)
REACT:R-RNO-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Rattus norvegicus)
RHEA:53808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Homo sapiens)
REACT:R-BTA-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Bos taurus)
REACT:R-DRE-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Danio rerio)
REACT:R-BTA-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Bos taurus)
GO:0038187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRR activity
GO:0038187	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	microbe-associated molecular pattern receptor activity
GO:0038187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pattern recognition receptor activity
GO:0038187	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pathogen associated molecular pattern receptor activity
GO:0038187	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	signaling pattern recognition receptor activity
GO:0038187	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PAMP receptor activity
GO:0038187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRR
GO:0038187	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MAMP receptor activity
GO:0038187	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	macrophage receptor activity
REACT:R-HSA-427409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA (Homo sapiens)
REACT:R-HSA-3095889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC dealkylates RCbl (Homo sapiens)
REACT:R-BTA-202375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ITK to SLP-76 (Bos taurus)
RHEA:66080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate
RHEA:60433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cannabigerolate => AH2 + cannabichromenate
RHEA:33313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + H(+) + H2O + N2 => 2 A + hydroxylamine + NH4(+)
GO:0033402	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine tRNA
GO:0033402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UUC codon-amino acid adaptor activity
GO:0033402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTC codon-amino acid adaptor activity
REACT:R-DRE-4090281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Danio rerio)
EC:1.14.3.-	skos:prefLabel	"With reduced pteridine as one donor"
EC:1.14.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With reduced pteridine as one donor"
RHEA:58215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 columbamine + O2 <=> 2 berberine + 2 H2O
REACT:R-RNO-1461993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-HD5 is cleaved by trypsin (Rattus norvegicus)
RHEA:42883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermine <=> H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine
REACT:R-HSA-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Homo sapiens)
RHEA:60342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine
RHEA:70580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DME-9654521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin dissociates KRAS4B from the plasma membrane (Drosophila melanogaster)
RHEA:36824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol => CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate
REACT:R-SSC-3134883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin enhances association of IRF3 with CBP/p300  (Sus scrofa)
RHEA:45350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine
REACT:R-HSA-8875371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	InlB binds MET (Homo sapiens)
RHEA:49585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose 1-phosphate => L-erythrulose 1-phosphate
RHEA:44167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O <=> adenine + D-ribose 5-triphosphate
REACT:R-GGA-265959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Chk2 by ATM upon DNA damage (Gallus gallus)
RHEA:46745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate => ADP + carboxyphosphate
REACT:R-DME-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Drosophila melanogaster)
REACT:R-CEL-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
RHEA:33006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Rattus norvegicus)
RHEA:24183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]
REACT:R-BTA-8983841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 associates with IL6ST:IL6ST (Bos taurus)
REACT:R-XTR-981728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to membrane-associated C3b (Xenopus tropicalis)
RHEA:70205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroxyindole-N-methyl => N-methyldopaminechrome
RHEA:64550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP] => N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP]
REACT:R-XTR-2247512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Xenopus tropicalis)
REACT:R-CEL-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Caenorhabditis elegans)
REACT:R-HSA-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Homo sapiens)
REACT:R-XTR-9012268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)
GO:0050492	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity
GO:0050492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-1-phosphate dehydrogenase [NAD(P)+] activity
REACT:R-MMU-392751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 linked to actin cytoskeleton by ankyrin (Mus musculus)
RHEA:37524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:41810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-[ACP] + H2O => (3R)-hydroxybutanoyl-[ACP]
GO:0036141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine:oxaloacetate transaminase activity
GO:0036141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine-oxaloacetate transaminase activity
RHEA:61411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-erythrulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine
REACT:R-DME-214864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
REACT:R-BTA-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Bos taurus)
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	procollagen-proline,2-oxoglutarate-4-dioxygenase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	prolyl hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocollagen proline hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	proline hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protocollagen hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proline protocollagen hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylase, collagen proline activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocollagen proline 4-hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	collagen proline hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	peptidyl proline hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocollagen proline dioxygenase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prolylprotocollagen dioxygenase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prolylprotocollagen hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	procollagen-proline 4-dioxygenase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocollagen prolyl hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	prolyl 4-hydroxylase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	proline, 2-oxoglutarate dioxygenase activity
GO:0004656	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	proline,2-oxoglutarate 4-dioxygenase activity
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	p-hydroxybenzoic acid hydroxylase activity
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	4-hydroxybenzoate 3-hydroxylase activity
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate monooxygenase activity
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate 3-monooxygenase activity
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	para-hydroxybenzoate hydroxylase activity
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoate-3-hydroxylase activity
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoate hydrolyase activity
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	p-hydroxybenzoate hydroxylase activity
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoic hydroxylase activity
GO:0018659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoic acid hydrolase activity
REACT:R-RNO-4615839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO2,3 (Rattus norvegicus)
REACT:R-SPO-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Schizosaccharomyces pombe)
REACT:R-XTR-9707523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to BACH1:MAFK (Xenopus tropicalis)
REACT:R-SSC-8950766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA dimerizes (Sus scrofa)
GO:0097243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonoid binding
REACT:R-MMU-2028735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind WWTR1 (TAZ) (Mus musculus)
REACT:R-BTA-68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated geminin is degraded by the proteasome (Bos taurus)
RHEA:42660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose
RHEA:42660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine 3-dehydrogenase"
RHEA:42660	skos:prefLabel	"UDP-N-acetylglucosamine 3-dehydrogenase"
RHEA:44669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)
RHEA:61333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + indoxyl sulfate(in) => ADP + H(+) + indoxyl sulfate(out) + phosphate
RHEA:14749	skos:prefLabel	"1-hydroxy-2-naphthoate 1,2-dioxygenase"
RHEA:14749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)
RHEA:14749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-hydroxy-2-naphthoate 1,2-dioxygenase"
RHEA:14749	skos:altLabel	"1-hydroxy-2-naphthoic acid dioxygenase"
RHEA:14749	skos:altLabel	"1-hydroxy-2-naphthoate-degrading enzyme"
REACT:R-DME-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Drosophila melanogaster)
REACT:R-HSA-379044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
REACT:R-XTR-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Xenopus tropicalis)
GO:0052664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitroalkane reductase activity
GO:0052664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitroalkane oxidase activity
GO:0052664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitroalkane:oxygen oxidoreductase activity
GO:0052664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAO activity
REACT:R-DRE-5607722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK phosphorylates IKKA dimer (Danio rerio)
RHEA:31439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = alpha-longipinene + diphosphate
RHEA:31439	skos:prefLabel	"alpha-longipinene synthase"
RHEA:31439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-longipinene synthase"
REACT:R-MMU-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Mus musculus)
RHEA:50678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-aspartyl-[protein] + NH4(+) => H(+) + H2O + N-terminal L-asparaginyl-[protein]
REACT:R-HSA-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Homo sapiens)
GO:0070908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine-tyramine antiporter activity
GO:0070908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine:tyramine antiporter activity
GO:0070908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine/tyramine antiporter activity
RHEA:20823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline sulfate + H2O <=> choline + H(+) + sulfate
GO:0103099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity
RHEA:29373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + phosphate => dAMP + H2O
REACT:R-BTA-9008928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Bos taurus)
RHEA:14268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-amino-5-oxopentanoate <=> 5-aminolevulinate
GO:0004658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionyl coenzyme A carboxylase activity
GO:0004658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PCCase activity
GO:0004658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
GO:0004658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA carboxylase activity
RHEA:65059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate + NADP(+) <=> 7-oxoglycolithocholate + H(+) + NADPH
RHEA:53845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate + NAD(+) => 7-oxoglycolithocholate + H(+) + NADH
REACT:R-GGA-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Gallus gallus)
REACT:R-DDI-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Dictyostelium discoideum)
RHEA:46043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + ATP <=> ADP + dCMP + H(+)
REACT:R-HSA-2395849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
GO:0050413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine 2-hydroxymethyltransferase activity
GO:0050413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity
GO:0050413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methylserine hydroxymethyltransferase activity
GO:0050413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine hydroxymethyltransferase activity
REACT:R-MMU-420980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Mus musculus)
RHEA:44294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine
REACT:R-MMU-213175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 oxidise AFB1 to AFXBO (Mus musculus)
EC:3.4.23.29	skos:prefLabel	"polyporopepsin"
EC:3.4.23.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polyporopepsin"
EC:3.4.23.29	skos:altLabel	"Polyporus aspartic proteinase"
RHEA:15429	skos:prefLabel	"anaerobilin synthase"
RHEA:15429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine
RHEA:15429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anaerobilin synthase"
RHEA:37151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-RNO-5625774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Rattus norvegicus)
REACT:R-DDI-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Dictyostelium discoideum)
RHEA:55095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + UDP-alpha-D-glucose <=> H(+) + sucrose + UDP
RHEA:57949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytoluene + H(+) + NADH + O2 => 3-methylcatechol + H2O + NAD(+)
RHEA:31038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabidiol <=> (S)-2,3-epoxysqualene + H2O
GO:0004925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prolactin receptor activity
REACT:R-DRE-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Danio rerio)
REACT:R-BTA-9756177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse ATVL to ATV (Bos taurus)
RHEA:65085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-4755536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates RELA with SUMO3 (Mus musculus)
RHEA:40436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine
REACT:R-CEL-1604690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MMP9 intermediate form by MMPs (Caenorhabditis elegans)
REACT:R-GGA-190260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b binds to FGF (Gallus gallus)
REACT:R-CFA-2187405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 binds phosphorylated SMAD2/3 (Canis familiaris)
GO:0016803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ether hydrolase activity
RHEA:16545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + oxalate = formate + oxalyl-CoA
REACT:R-CFA-3262512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Canis familiaris)
REACT:R-SSC-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Sus scrofa)
REACT:R-HSA-8869456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)
RHEA:30593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + tyramine
REACT:R-BTA-9650473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 is secreted (Bos taurus)
RHEA:31039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + FAD + H(+) = (2E)-dodecenoyl-CoA + FADH2
GO:0042878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate transmembrane transporter activity
EC:2.3.1.265	skos:prefLabel	"phosphatidylinositol dimannoside acyltransferase"
EC:2.3.1.265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol dimannoside acyltransferase"
EC:2.3.1.265	skos:altLabel	"PIM2 acyltransferase"
REACT:R-DRE-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Danio rerio)
RHEA:37200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
RHEA:72143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + GTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine
REACT:R-HSA-443402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)
REACT:R-SSC-5685011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR activation at DNA DSBs (Sus scrofa)
REACT:R-DME-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Drosophila melanogaster)
RHEA:22975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + CoA + NADP(+) <=> butanoyl-CoA + H(+) + NADPH
REACT:R-SSC-2214324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII dimerization (Sus scrofa)
REACT:R-GGA-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Gallus gallus)
REACT:R-HSA-6814409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates PDCL (Homo sapiens)
REACT:R-SCE-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Saccharomyces cerevisiae)
REACT:R-DME-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Drosophila melanogaster)
REACT:R-CEL-114548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Caenorhabditis elegans)
REACT:R-SSC-1497869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - Sepiapterin is reduced to BH2 (Sus scrofa)
RHEA:36694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-octadecanoylsphing-4-enine
REACT:R-HSA-5638006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3 hydrolyzes GTP (Homo sapiens)
RHEA:30955	skos:prefLabel	"9,9'-di-cis-zeta-carotene desaturase"
RHEA:30955	skos:altLabel	"zeta-carotene desaturase"
RHEA:30955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"9,9'-di-cis-zeta-carotene desaturase"
RHEA:30955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol
RHEA:30955	skos:altLabel	"ZDS"
GO:0102292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30-hydroxy-beta-amyrin 11-hydroxylase activity
RHEA:48488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-retinal--[retinol-binding protein] + H(+) + NADH
RHEA:58011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside F1 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg1 + H(+) + UDP
REACT:R-MMU-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Mus musculus)
GO:0008877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucose-1-phosphate phosphohydrolase activity
GO:0008877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-1-phosphatase activity
GO:0008877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose-1-phosphate phosphohydrolase activity
RHEA:62019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
REACT:R-HSA-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)
REACT:R-CFA-9641089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin binds Ub:UBE2N:UBE2V1 (Canis familiaris)
REACT:R-SPO-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Schizosaccharomyces pombe)
REACT:R-DRE-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Danio rerio)
REACT:R-GGA-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Gallus gallus)
REACT:R-CFA-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Canis familiaris)
REACT:R-PFA-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Plasmodium falciparum)
REACT:R-XTR-176521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Xenopus tropicalis)
REACT:R-SSC-430096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds filamin (Sus scrofa)
REACT:R-DRE-1295599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 translocates to the plasma membrane (Danio rerio)
RHEA:29250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+)(out) + 2 Na(+)(in) <=> 3 H(+)(in) + 2 Na(+)(out)
RHEA:25824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermine = H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine
REACT:R-CFA-8875071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSS3 ligates CoA to CH3COO- (Canis familiaris)
REACT:R-CEL-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Caenorhabditis elegans)
REACT:R-CFA-9609310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β-blockers bind ADRB1,2,3 (Canis familiaris)
RHEA:64215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-isoleucine + H2O <=> a fatty acid + L-isoleucine
REACT:R-MMU-8938108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds cathepsin L (Mus musculus)
REACT:R-XTR-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Xenopus tropicalis)
RHEA:50543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin A2 <=> prostaglandin C2
REACT:R-HSA-1564164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type V degradation by MMP2,9,10 (Homo sapiens)
REACT:R-MMU-391935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP1 receptor can bind PGD2 (Mus musculus)
REACT:R-MMU-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Mus musculus)
GO:0004511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine hydroxylase activity
GO:0004511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine 3-hydroxylase activity
GO:0004511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
GO:0004511	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
GO:0004511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine 3-monooxygenase"
GO:0004511	skos:altLabel	"tyrosine 3-hydroxylase"
GO:0004511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine 3-monooxygenase activity
GO:0004511	skos:prefLabel	"tyrosine 3-monooxygenase"
GO:0004511	skos:altLabel	"tyrosine hydroxylase"
GO:0004511	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine hydroxylase activity
GO:0004511	skos:altLabel	"L-tyrosine hydroxylase"
REACT:R-RNO-196372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Rattus norvegicus)
RHEA:22829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-ATP + H2O => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)
REACT:R-HSA-3343700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
REACT:R-BTA-5686304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Bos taurus)
REACT:R-DDI-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Dictyostelium discoideum)
RHEA:52337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + H(+) => a long-chain fatty acyl-AMP + diphosphate
REACT:R-XTR-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Xenopus tropicalis)
RHEA:65993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + hnu => 5,6-trans-vitamin D3
REACT:R-BTA-8934742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRMT1 (Bos taurus)
REACT:R-DRE-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Danio rerio)
RHEA:52413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + NAD(+) => 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH
REACT:R-DRE-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Danio rerio)
REACT:R-BTA-6799761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds PPP1R13L (Bos taurus)
RHEA:17798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)
RHEA:65285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate => 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)
REACT:R-SSC-180038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Sus scrofa)
REACT:R-RNO-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Rattus norvegicus)
RHEA:15919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldono-1,5-lactone + H(+) + NADH => an aldopyranose + NAD(+)
RHEA:30226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + hydrogen sulfide <=> 2 Fe(II)-[cytochrome c] + H(+) + sulfur
REACT:R-CEL-4722133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Caenorhabditis elegans)
RHEA:44896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP
REACT:R-XTR-5654402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
RHEA:59557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiono-1,5-lactone => H(+) + N,N'-diacetylchitobionate
REACT:R-SSC-9029680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-7 translocates to the nucleus (Sus scrofa)
RHEA:47855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate
REACT:R-BTA-8942344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 transports FOLA from extracellular region to cytosol (Bos taurus)
REACT:R-HSA-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Homo sapiens)
RHEA:33755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexadecanoate
REACT:R-RNO-2395872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)
REACT:R-HSA-202233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Lck by Csk (Homo sapiens)
RHEA:12021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monocarboxylic acid amide + H2O => a monocarboxylate + NH4(+)
REACT:R-DDI-5672954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Dictyostelium discoideum)
RHEA:60064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)
REACT:R-XTR-9706393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds ATP (Xenopus tropicalis)
REACT:R-MMU-8858346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMHR2 binds AMH (Mus musculus)
RHEA:36559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cis-4-hydroxy-D-proline = 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)
REACT:R-BTA-2514790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by MMP14 (Bos taurus)
RHEA:70735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + glycine betaine(out) + 2 Na(+)(out) = chloride(in) + glycine betaine(in) + 2 Na(+)(in)
REACT:R-DDI-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Dictyostelium discoideum)
RHEA:14587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DDI-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Dictyostelium discoideum)
REACT:R-SSC-5672961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates inactive RAFs (Sus scrofa)
REACT:R-MMU-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)
REACT:R-BTA-373073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR1, 2 and 8 bind CCL16 ligand (Bos taurus)
REACT:R-MMU-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Mus musculus)
REACT:R-XTR-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Xenopus tropicalis)
RHEA:15233	skos:altLabel	"nitrite reductase"
RHEA:15233	skos:altLabel	"cytochrome cd1"
RHEA:15233	skos:altLabel	"nitrite reductase (cytochrome)"
RHEA:15233	skos:prefLabel	"nitrite reductase (NO-forming)"
RHEA:15233	skos:altLabel	"cytochrome c-551:O2, NO2(+) oxidoreductase"
RHEA:15233	skos:altLabel	"Pseudomonas cytochrome oxidase"
RHEA:15233	skos:altLabel	"cytochrome cd"
RHEA:15233	skos:altLabel	"methyl viologen-nitrite reductase"
RHEA:15233	skos:altLabel	"hydroxylamine (acceptor) reductase"
RHEA:15233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite
RHEA:15233	skos:altLabel	"nitrite reductase (cytochrome; NO-forming)"
RHEA:15233	skos:altLabel	"cd-cytochrome nitrite reductase"
RHEA:15233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrite reductase (NO-forming)"
REACT:R-SSC-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Sus scrofa)
REACT:R-MMU-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Mus musculus)
RHEA:72630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + Zn(2+)(in) <=> 2 H(+)(in) + Zn(2+)(out)
RHEA:15404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-alpha-D-glucose <=> a dolichyl beta-D-glucosyl phosphate + UDP
REACT:R-GGA-1974676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta defensin 103 activates TLR1:TLR2 (Gallus gallus)
REACT:R-SPO-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Schizosaccharomyces pombe)
REACT:R-DRE-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Danio rerio)
REACT:R-DDI-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Dictyostelium discoideum)
REACT:R-CFA-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Canis familiaris)
REACT:R-CFA-8854628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLIP dimer ubiquitinates VLDLR on Lys-839 (Canis familiaris)
REACT:R-BTA-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Bos taurus)
REACT:R-MMU-73722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of UBF-1:rDNA Promoter (Mus musculus)
RHEA:29880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-arginine(out) => ADP + H(+) + L-arginine(in) + phosphate
REACT:R-MMU-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Mus musculus)
REACT:R-RNO-9734475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds fibrates (Rattus norvegicus)
RHEA:11071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose
RHEA:64276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrysophanol-9-anthrone + O2 = chrysophanol + H2O
REACT:R-SPO-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Schizosaccharomyces pombe)
RHEA:55567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxytryptamine + ATP <=> 4-hydoxytryptamine 4-phosphate + ADP + H(+)
REACT:R-HSA-1638053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)
RHEA:32044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => 2 ATP + 2 H(+)
REACT:R-SPO-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Schizosaccharomyces pombe)
RHEA:41123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)
REACT:R-DME-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Drosophila melanogaster)
REACT:R-DME-5226904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Drosophila melanogaster)
REACT:R-RNO-5676596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds BAFFR:BAFF (Rattus norvegicus)
RHEA:39589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH
REACT:R-DRE-174238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Danio rerio)
REACT:R-MMU-6786092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4:IL4R:JAK2 binds IL2RG:JAK3 (Mus musculus)
RHEA:54602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octanoyl-CoA
EC:2.2.1.1	skos:prefLabel	"transketolase"
EC:2.2.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"transketolase"
EC:2.2.1.1	skos:altLabel	"glycoaldehyde transferase"
REACT:R-RNO-6783552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM binds LIFR:JAKs,OSMR:JAKs (Rattus norvegicus)
GO:0051062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP reductase activity
GO:0051062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP reduction
RHEA:38100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + phytyl phosphate => a ribonucleoside 5'-diphosphate + phytyl diphosphate
REACT:R-RNO-70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate + H2O => 4-imidazolone-5-propionate (Rattus norvegicus)
RHEA:50823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> H(+) + NADPH + testosterone
RHEA:39417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH
GO:0106368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor
GO:0106368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP
RHEA:54451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-alpha-aminoacyl-tRNA + H2O <=> a tRNA + an N-acyl-L-amino acid + H(+)
RHEA:31457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + riboflavin => NAD(+) + reduced riboflavin
REACT:R-CEL-8874083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y397-PTK2 binds SRC (Caenorhabditis elegans)
GO:0047382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylphosphothioglycerate phosphatase activity
GO:0047382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity
GO:0047382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylthiophosphoglycerate phosphatase activity
RHEA:67154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein]
REACT:R-BTA-9020251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Bos taurus)
RHEA:12987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
REACT:R-CEL-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)
GO:0001092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIA-class transcription factor binding
GO:0001092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIA-class transcription factor complex binding
REACT:R-GGA-5635843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI translocates to the nucleus (Gallus gallus)
RHEA:26189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP
REACT:R-GGA-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Gallus gallus)
REACT:R-DRE-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Danio rerio)
REACT:R-GGA-202731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM3 dimerises (Gallus gallus)
RHEA:49599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-acyl-D-galactosylsphing-4-enine + UDP
RHEA:66376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + H2O = D-erythrose + phosphate
REACT:R-SSC-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Sus scrofa)
RHEA:42128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine
RHEA:66935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate <=> avenanthramide A + CoA
RHEA:66778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + uroporphyrin III(out) => ATP + H2O + uroporphyrin III(in)
GO:0120296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)
GO:0120296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide dopaminyltransferase activity
RHEA:31406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) <=> all-trans-4,4'-diaponeurosporene + FADH2
REACT:R-DDI-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)
REACT:R-DDI-1169402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of E2 conjugating enzymes (Dictyostelium discoideum)
RHEA:54180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + holo-[ACP] + NAD(+) = a long-chain fatty acyl-[ACP] + H(+) + NADH
RHEA:40321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetracosenoyl-CoA + H2O2 => O2 + tetracosanoyl-CoA
RHEA:10589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH => 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]
RHEA:19264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + heme b(in) <=> ADP + H(+) + heme b(out) + phosphate
REACT:R-SSC-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Sus scrofa)
RHEA:10528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10528	skos:altLabel	"dihydrosanguinarine 10-hydroxylase"
RHEA:10528	skos:prefLabel	"dihydrosanguinarine 10-monooxygenase"
RHEA:10528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrosanguinarine 10-monooxygenase"
GO:0008254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-ribonucleotide phosphohydrolase activity
GO:0008254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' nucleotidase activity
GO:0008254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-ribonucleotidase activity
GO:0008254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-nucleotidase activity
GO:0008254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphatase activity
GO:0008254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-mononucleotidase activity
RHEA:27825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-acetyl-L-homoserine <=> acetate + L-homocysteine
RHEA:30090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2
REACT:R-DME-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Drosophila melanogaster)
REACT:R-DME-173488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)
REACT:R-RNO-76416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Benzene is hydroxylated to phenol (Rattus norvegicus)
REACT:R-MMU-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Mus musculus)
REACT:R-GGA-5654633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS bind to PPTN11 (Gallus gallus)
EC:2.7.11.1	skos:altLabel	"protein-serine kinase"
EC:2.7.11.1	skos:altLabel	"serine-specific protein kinase"
EC:2.7.11.1	skos:prefLabel	"non-specific serine/threonine protein kinase"
EC:2.7.11.1	skos:altLabel	"protein serine-threonine kinase"
EC:2.7.11.1	skos:altLabel	"protein serine kinase"
EC:2.7.11.1	skos:altLabel	"serine(threonine) protein kinase"
EC:2.7.11.1	skos:altLabel	"serine/threonine protein kinase"
EC:2.7.11.1	skos:altLabel	"serine protein kinase"
EC:2.7.11.1	skos:altLabel	"serine kinase"
EC:2.7.11.1	skos:altLabel	"protein phosphokinase"
EC:2.7.11.1	skos:altLabel	"threonine-specific protein kinase"
EC:2.7.11.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"non-specific serine/threonine protein kinase"
RHEA:68736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] = ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-5618085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)
RHEA:12502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH => (3R)-1,4-thiomorpholine-3-carboxylate + NADP(+)
RHEA:66212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-omegaC5-CoA + O2 = asc-omegaDeltaC5-CoA + H2O2
RHEA:16300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH
REACT:R-SSC-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Sus scrofa)
REACT:R-SPO-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Schizosaccharomyces pombe)
RHEA:55869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + O2 => H2O2 + pyruvate
GO:0030771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity
GO:0030771	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	benzoyl-CoA:anthranilate N-benzoyltransferase
GO:0030771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity
GO:0030771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity
RHEA:35764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-451366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38MAPK by DSCAM (Drosophila melanogaster)
REACT:R-RNO-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Rattus norvegicus)
REACT:R-HSA-9630044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective NTHL1 truncation mutants do not bind formamidopyrimidine (FapyA) (Homo sapiens)
REACT:R-HSA-192830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral Polymerase Assembly (Homo sapiens)
RHEA:34929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + glutathioselenol + NADP(+) => H(+) + NADPH + selenodiglutathione
RHEA:68598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-XTR-391942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP receptor can bind prostacyclin (Xenopus tropicalis)
REACT:R-HSA-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-GGA-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Gallus gallus)
RHEA:69352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (E)-prop-1-en-1-SO-peroxol = H2O + thiosulfinate
RHEA:11265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 => H2O2 + NAD(+)
REACT:R-SCE-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Saccharomyces cerevisiae)
REACT:R-SSC-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Sus scrofa)
REACT:R-SSC-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Sus scrofa)
RHEA:31042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + FAD + H(+) <=> (2E)-dodecenoyl-CoA + FADH2
RHEA:34469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + valerena-4,7(11)-diene => (2E,6E)-farnesyl diphosphate
REACT:R-CFA-8956184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Canis familiaris)
REACT:R-RNO-2130393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex along Golgi to TGN (Rattus norvegicus)
REACT:R-DRE-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Danio rerio)
REACT:R-HSA-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
RHEA:70777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite => 6-sulfo-D-quinovose + FMNH2 + O2
REACT:R-MMU-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Mus musculus)
REACT:R-XTR-8874201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L3 (Xenopus tropicalis)
RHEA:66910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A => acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine
REACT:R-DRE-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Danio rerio)
EC:3.4.22.49	skos:altLabel	"separin"
EC:3.4.22.49	skos:prefLabel	"separase"
EC:3.4.22.49	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"separase"
REACT:R-CFA-909730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of INFAR1 by TYK2 (Canis familiaris)
REACT:R-MMU-9648017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 binds to microtubules (Mus musculus)
REACT:R-BTA-1678921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length TLR3/7/8/9 binds to UNC93B1 (Bos taurus)
REACT:R-XTR-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Xenopus tropicalis)
REACT:R-RNO-1234173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)
RHEA:37033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-arabinonate + H2O => D-ribonate
RHEA:39534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)
RHEA:22417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + H(+) => catechol + CO2
RHEA:52881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:52807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-eremophilene + diphosphate
RHEA:63325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycerol + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)
RHEA:70536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] => 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)
REACT:R-MMU-514604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Mus musculus)
RHEA:58044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + alpha,alpha-trehalose = 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA
RHEA:58044	skos:prefLabel	"long-chain-acyl-CoA--trehalose acyltransferase"
RHEA:58044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-acyl-CoA--trehalose acyltransferase"
GO:0102312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl 2'-hydroxylase activity
GO:0102312	skos:prefLabel	"trans-4-coumaroyl-CoA 2'-hydroxylase"
GO:0102312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 = (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate
GO:0102312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-4-coumaroyl-CoA 2'-hydroxylase"
REACT:R-PFA-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Plasmodium falciparum)
RHEA:25007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-8878054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 (Bos taurus)
REACT:R-SPO-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Schizosaccharomyces pombe)
RHEA:40940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH => 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)
RHEA:67420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid + H2O = a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)
RHEA:31589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + uracil
REACT:R-SPO-5082384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70:DNAJB1 binds HSF1 (Schizosaccharomyces pombe)
REACT:R-MMU-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Mus musculus)
RHEA:54157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 => [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate
RHEA:11441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5,6-tetrachlorophenol + NADPH + O2 => 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)
REACT:R-DRE-176250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR-ATRIP to the RPA-ssDNA complex (Danio rerio)
REACT:R-MMU-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Mus musculus)
RHEA:46530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-BTA-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Bos taurus)
RHEA:53484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,11,17-trione + H(+) + NADPH = 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)
REACT:R-BTA-5634802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Bos taurus)
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histidine permease activity
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent polar amino acid-transporter activity
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled polar amino acid-transporter activity
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cystine/diaminopimelate porter activity
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate/aspartate porter activity
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polar-amino-acid-transporting ATPase activity
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polar amino acid uptake transporter activity
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine/arginine/lysine/ornithine porter activity
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polar amino acid-importing ATPase activity
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	polar-amino acid ABC transporter
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polar-amino acid-importing ATPase activity
GO:0015426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polar-amino acid-transporting ATPase activity
GO:0030775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronoxylan 4-O-methyltransferase activity
GO:0030775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity
REACT:R-RNO-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Rattus norvegicus)
RHEA:13944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glyceraldehyde <=> ADP + D-glyceraldehyde 3-phosphate + H(+)
REACT:R-DME-2179413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC-alpha  activate MMP3 (Drosophila melanogaster)
REACT:R-GGA-353472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase (Gallus gallus)
REACT:R-GGA-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Gallus gallus)
RHEA:23274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP => an N(6)-alkylaminopurine + UDP-alpha-D-glucose
REACT:R-CEL-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Caenorhabditis elegans)
RHEA:39043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)
REACT:R-SPO-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Schizosaccharomyces pombe)
RHEA:10746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + CO2 + NADH => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)
REACT:R-DDI-75872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Dictyostelium discoideum)
RHEA:47864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate
RHEA:68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) + tellurite(in) = Na(+)(out) + tellurite(out)
GO:0045462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trichothecene 3-O-acetyltransferase activity
RHEA:52489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0061778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular chloride channel activity
REACT:R-HSA-917987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFRC dimer binds 2xholoTF (Homo sapiens)
RHEA:23136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-5610733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Homo sapiens)
RHEA:48050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + ganglioside GM2 (d18:1(4E)) => ganglioside GM1 (d18:1(4E)) + H2O
RHEA:54613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylbutanoyl-CoA + O2 => 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate
GO:0103056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity
GO:0046906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrapyrrole binding
GO:0046906	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	porphyrin binding
REACT:R-CFA-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Canis familiaris)
REACT:R-DME-4755536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates RELA with SUMO3 (Drosophila melanogaster)
REACT:R-MMU-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Mus musculus)
REACT:R-HSA-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)
REACT:R-XTR-210974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS-1 to Tie2 bound  Grb2 (Xenopus tropicalis)
REACT:R-HSA-5610722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI3 (Homo sapiens)
REACT:R-DME-4793911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates HSF1 (Drosophila melanogaster)
GO:0015284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose uniporter activity
GO:0001155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIIA-class transcription factor binding
RHEA:67295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one
REACT:R-HSA-184269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex (Homo sapiens)
REACT:R-MMU-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Mus musculus)
GO:0008169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-methyltransferase activity
REACT:R-SSC-8943959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP9 cleave SCUBE3 (Sus scrofa)
GO:0052828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-3,4-bisphosphate 4-phosphatase activity
RHEA:52049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)
REACT:R-CEL-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Caenorhabditis elegans)
RHEA:60309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine
GO:0035255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ionotropic glutamate receptor binding
GO:0120136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP-kinase activity
GO:0120136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dUMP = ADP + dUDP
GO:0120136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP kinase activity
GO:0120136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:dUMP phosphotransferase activity
GO:0120136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyuridine monophosphate kinase activity
REACT:R-GGA-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Gallus gallus)
RHEA:28701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mn(2+)(out) => Mn(2+)(in)
RHEA:35913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate
REACT:R-XTR-3000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BORA binds PLK1 and AURKA (Xenopus tropicalis)
REACT:R-DDI-139855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X1-mediated entry of Ca++ from plasma (Dictyostelium discoideum)
REACT:R-RNO-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Rattus norvegicus)
RHEA:71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(in) + L-tryptophan(out) => L-histidine(out) + L-tryptophan(in)
RHEA:42346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => H(+) + NADH + O2 + p-cumate
REACT:R-MMU-6785648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEMO1 binds RHOA:GTP:DIAPH1 (Mus musculus)
RHEA:40592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanedioyl-CoA + H2O => CoA + decanedioate + H(+)
RHEA:55755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:37031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribonate = 2-dehydro-3-deoxy-D-arabinonate + H2O
REACT:R-HSA-8870678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fibrinogen products bind TLR4:LY96 (Homo sapiens)
RHEA:31632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate => phosphate + pseudaminate
RHEA:47907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(acetyl)-sphing-4-enine <=> ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate
REACT:R-DRE-9624112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK4 (Danio rerio)
GO:0102420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity
REACT:R-CFA-4085217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Canis familiaris)
RHEA:63374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-acyl-L-cysteinyl-[protein] + CoA => an acyl-CoA + L-cysteinyl-[protein]
REACT:R-SCE-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Saccharomyces cerevisiae)
REACT:R-HSA-6806974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET dimers autophosphorylate (Homo sapiens)
REACT:R-CFA-2179413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC-alpha  activate MMP3 (Canis familiaris)
REACT:R-DME-9611751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1,2-agonists bind ADRB1,2 (Drosophila melanogaster)
REACT:R-HSA-200143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
GO:0036382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dependent flavin reductase activity
GO:0036382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin:NADH oxidoreductase activity
GO:0036382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavin reductase (NADH) activity
RHEA:18274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + putrescine => 4-aminobutanal + H2O2 + NH4(+)
RHEA:19996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (S)-S-oxide
RHEA:55605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base
REACT:R-BTA-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Bos taurus)
RHEA:34524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-GGA-5694109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer hydrolyses TAG to DAG and FA (Gallus gallus)
RHEA:48193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-5696945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates CCP110,ARRB (Homo sapiens)
REACT:R-GGA-9796387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Gallus gallus)
GO:0015471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-specific channel forming porin activity
EC:3.4.22.30	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caricain"
EC:3.4.22.30	skos:altLabel	"papaya proteinase Omega"
EC:3.4.22.30	skos:altLabel	"papaya proteinase Q"
EC:3.4.22.30	skos:altLabel	"papaya proteinase III"
EC:3.4.22.30	skos:altLabel	"papaya peptidase A"
EC:3.4.22.30	skos:altLabel	"papaya peptidase II"
EC:3.4.22.30	skos:prefLabel	"caricain"
REACT:R-XTR-4084999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU1 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)
REACT:R-CFA-2130619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosomal vesicle coat assembly (Canis familiaris)
REACT:R-MMU-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Mus musculus)
RHEA:21402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADPH + succinyl-CoA => 2-oxoglutarate + CoA + NADP(+)
REACT:R-SSC-8950731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:IL27 translocates to the extracellular region (Sus scrofa)
RHEA:63315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate
REACT:R-BTA-5607751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes (Bos taurus)
RHEA:26553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-piperazine-2-carboxamide + H2O <=> (S)-piperazine-2-carboxylate + NH4(+)
RHEA:35885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-CFA-9749505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC14 binds IKBKB and CHUK (Canis familiaris)
REACT:R-XTR-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)
RHEA:23103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dAMP <=> ADP + dADP
REACT:R-DRE-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Danio rerio)
GO:0050252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinol fatty-acyltransferase activity
GO:0050252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinol acyltransferase activity
GO:0050252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:retinol O-acyltransferase activity
GO:0050252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinol O-fatty-acyltransferase activity
REACT:R-DME-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Drosophila melanogaster)
REACT:R-SCE-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)
RHEA:58793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Fe(III)-petrobactin(out) + H2O => ADP + Fe(III)-petrobactin(in) + H(+) + phosphate
GO:0047011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-pantolactone:NADP+ oxidoreductase (A-specific)
GO:0047011	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-oxopantoyl lactone reductase
GO:0047011	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ketopantoyl lactone reductase activity
GO:0047011	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-ketopantoyl lactone reductase activity
GO:0047011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydropantoyl-lactone reductase (A-specific) activity
GO:0047011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantolactone reductase (A-specific) activity
REACT:R-RNO-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Rattus norvegicus)
RHEA:45675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-CFA-166869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MEKK1 (Canis familiaris)
GO:0047646	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bacterial luciferase activity
GO:0047646	skos:altLabel	"aldehyde monooxygenase"
GO:0047646	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)
GO:0047646	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vibrio fischeri luciferase activity
GO:0047646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacterial luciferase"
GO:0047646	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aldehyde monooxygenase activity
GO:0047646	skos:altLabel	"alkanal monooxygenase (FMN-linked)"
GO:0047646	skos:prefLabel	"bacterial luciferase"
GO:0047646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkanal monooxygenase (FMN-linked) activity
GO:0047646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + FMNH2 + O2 = a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu
REACT:R-SSC-977363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3bBb (Sus scrofa)
REACT:R-SSC-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Sus scrofa)
RHEA:68275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + L-seryl-[protein] <=> CoA + O-fatty acyl-L-seryl-[protein]
RHEA:35332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH
RHEA:28569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP <=> 6 AMP + enterobactin + 7 H(+)
RHEA:42691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide <=> A + ergothioneine + NH4(+) + pyruvate
RHEA:23289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + CoA + NAD(+) => acetyl-CoA + H(+) + NADH
REACT:R-GGA-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Gallus gallus)
RHEA:30473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S,6S)-alpha-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate
RHEA:23717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-dodecenoyl-CoA => (2E)-dodecenoyl-CoA
REACT:R-RNO-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Rattus norvegicus)
RHEA:72322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n chloride(in) + urate(out) <=> n chloride(out) + urate(in)
RHEA:35757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + UDP-3-oxo-alpha-D-glucose => NAD(+) + UDP-alpha-D-glucose
REACT:R-HSA-5623705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:64230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine
GO:0102767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4'-hydroxyflavanone + S-adenosyl-L-methionine = a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine
GO:0102767	skos:altLabel	"isoflavone O-methyltransferase"
GO:0102767	skos:prefLabel	"flavonoid 4'-O-methyltransferase"
GO:0102767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavanone 4'-O-methyltransferase activity
GO:0102767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonoid 4'-O-methyltransferase"
GO:0102767	skos:altLabel	"4'-hydroxyisoflavone methyltransferase"
RHEA:25382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methylhexadecanoyl-CoA <=> 2-methylpentadecanal + formyl-CoA
RHEA:53523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-MMU-8941543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Mus musculus)
REACT:R-XTR-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Xenopus tropicalis)
REACT:R-CFA-8854302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D7 binds the TSC1-TSC2 complex (Canis familiaris)
RHEA:14756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050199	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity
GO:0050199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	piperidine N-piperoyltransferase activity
GO:0050199	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	piperidine piperoyltransferase activity
GO:0050199	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	piperoyl-CoA:piperidine N-piperoyltransferase activity
REACT:R-BTA-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Bos taurus)
RHEA:22222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ent-kaur-16-ene => ent-copalyl diphosphate
REACT:R-CEL-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Caenorhabditis elegans)
RHEA:32587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)
REACT:R-XTR-383313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like Peptide 1 is secreted from intestinal L cells (Xenopus tropicalis)
REACT:R-DME-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Drosophila melanogaster)
RHEA:31054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-beta-leucine + H2O + NAD(+) <=> 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)
REACT:R-HSA-9732527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds rosiglitazone (Homo sapiens)
GO:0047924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geraniol:NADP+ oxidoreductase activity
GO:0047924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geraniol dehydrogenase activity
REACT:R-GGA-5577213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Gallus gallus)
RHEA:63362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2
REACT:R-GGA-1358790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates ERBB3 (Gallus gallus)
REACT:R-CFA-1678742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses Heparan sulfate chain(4) (Canis familiaris)
RHEA:21049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + isopropylamine + L-glutamate => ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate
REACT:R-XTR-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Xenopus tropicalis)
REACT:R-HSA-8983384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
RHEA:48182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein]
EC:3.4.23.42	skos:prefLabel	"thermopsin"
EC:3.4.23.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thermopsin"
REACT:R-SSC-9674816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Sus scrofa)
REACT:R-HSA-4086132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin phosphoprotein binds integrin alphaVbeta1 (Homo sapiens)
REACT:R-XTR-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Xenopus tropicalis)
REACT:R-SSC-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Sus scrofa)
REACT:R-MMU-83656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Mus musculus)
RHEA:28022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[ACP] + octanoate = AMP + diphosphate + octanoyl-[ACP]
REACT:R-RNO-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Rattus norvegicus)
GO:0102207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate omega-hydroxylase activity
GO:0102207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	behenate omega-hydroxylase activity
REACT:R-MMU-382052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130Cas and C3G bind PDGFR bound Crk (Mus musculus)
RHEA:40383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
REACT:R-DRE-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Danio rerio)
REACT:R-MMU-210283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and PLC gamma1 (Mus musculus)
RHEA:65195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + 2 O2 + preaustinoid A <=> berkeleytrione + 2 CO2 + H2O + 2 succinate
REACT:R-PFA-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Plasmodium falciparum)
RHEA:16672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + xanthine <=> H(+) + NADH + urate
GO:0047744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)
GO:0047744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chloridazon-catechol dioxygenase"
GO:0047744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloridazon-catechol dioxygenase activity
GO:0047744	skos:prefLabel	"chloridazon-catechol dioxygenase"
GO:0047744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)
REACT:R-HSA-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Homo sapiens)
REACT:R-CEL-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Caenorhabditis elegans)
GO:0008200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion channel inhibitor activity
RHEA:42257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanoyl-CoA + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + CoA
REACT:R-HSA-9687121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp8 binds MAP1LC3B (Homo sapiens)
REACT:R-HSA-183067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Localization of CBL:GRB2 to the membrane (Homo sapiens)
REACT:R-SSC-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Sus scrofa)
REACT:R-DME-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Drosophila melanogaster)
REACT:R-RNO-3341296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX7,8 catalyze peroxidation of P4HB (PDI) (Rattus norvegicus)
REACT:R-GGA-5686685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Gallus gallus)
REACT:R-GGA-166245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Gallus gallus)
RHEA:22851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyoctanedioyl-CoA + NAD(+) <=> 3-oxooctanedioyl-CoA + H(+) + NADH
REACT:R-MMU-376364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp8 associated secretory vesicle to plasma membrane transport (Mus musculus)
REACT:R-CFA-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Canis familiaris)
RHEA:30337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + UTP => CTP + H(+) + H2O
RHEA:16868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + propanoyl-CoA <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA
RHEA:67444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA
RHEA:56119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-decaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)
RHEA:50910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-demethylubiquinol + H2O => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2
REACT:R-RNO-9026911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Rattus norvegicus)
REACT:R-XTR-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Xenopus tropicalis)
REACT:R-HSA-1676005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Homo sapiens)
REACT:R-DDI-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Dictyostelium discoideum)
RHEA:57918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+) => ATP + L-aspartyl-tRNA(Asn)
RHEA:22300	skos:altLabel	"UDP-glucose flavonol 3-O-glucosyltransferase"
RHEA:22300	skos:prefLabel	"flavonol 3-O-glucosyltransferase"
RHEA:22300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonol 3-O-glucosyltransferase"
RHEA:22300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucoside + H(+) + UDP
REACT:R-MMU-416683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA3E binds to PLXND1 (Mus musculus)
REACT:R-CFA-5653974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator binds Rag dimers (Canis familiaris)
RHEA:43616	skos:prefLabel	"molybdopterin-synthase adenylyltransferase"
RHEA:43616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"molybdopterin-synthase adenylyltransferase"
RHEA:43616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate
RHEA:21918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+) => an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O
RHEA:59475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP + H2O <=> Gp(2'-5')Ap(3') + H(+)
REACT:R-RNO-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Rattus norvegicus)
REACT:R-SPO-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Schizosaccharomyces pombe)
RHEA:54950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5Z)-dodecadienoyl-[ACP] + H2O => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP]
REACT:R-XTR-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Xenopus tropicalis)
REACT:R-RNO-193845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)
REACT:R-SPO-5433067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Schizosaccharomyces pombe)
REACT:R-MMU-8944220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIII (Mus musculus)
REACT:R-SSC-5218836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2beta binds alphaVbeta3 (Sus scrofa)
REACT:R-DRE-9712210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Danio rerio)
GO:0018852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
GO:0018852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichloromuconate cycloisomerase activity
REACT:R-HSA-8875540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 recruits CRK,CRKL to MET (Homo sapiens)
REACT:R-DME-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)
REACT:R-XTR-174427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Xenopus tropicalis)
RHEA:14042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-vicianin + H2O => mandelonitrile + vicianose
RHEA:24120	skos:altLabel	"leukotriene-E4 omega-hydroxylase"
RHEA:24120	skos:prefLabel	"leukotriene-E4 20-monooxygenase"
RHEA:24120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leukotriene-E4 20-monooxygenase"
RHEA:24120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + leukotriene E4 + NADPH + O2 = 20-hydroxy-leukotriene E4 + H2O + NADP(+)
EC:2.5.1.39	skos:prefLabel	"4-hydroxybenzoate polyprenyltransferase"
EC:2.5.1.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoate polyprenyltransferase"
EC:2.5.1.39	skos:altLabel	"4-hydroxybenzoate nonaprenyltransferase"
RHEA:19038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an epoxide + H2O => an ethanediol
GO:0004463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTA4 hydrolase activity
GO:0004463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene A4 hydrolase activity
GO:0004463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene-A4 hydrolase activity
GO:0004463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTA4H
GO:0004463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity
GO:0004463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTA-4 hydrolase activity
GO:0004463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene A(4) hydrolase activity
RHEA:10972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoramidate--hexose phosphotransferase"
RHEA:10972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-hexose + H(+) + phosphoramidate = alpha-D-hexose 1-phosphate + NH4(+)
RHEA:10972	skos:prefLabel	"phosphoramidate--hexose phosphotransferase"
REACT:R-BTA-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Bos taurus)
REACT:R-HSA-204873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shp2 (Homo sapiens)
REACT:R-GGA-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Gallus gallus)
RHEA:17901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthotoxol = H(+) + S-adenosyl-L-homocysteine + xanthotoxin
GO:0031078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K14 deacetylase activity
GO:0031078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone deacetylase activity (H3-K14 specific)
GO:0031078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K14 deacetylase activity
GO:0008098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S rRNA primary transcript binding
REACT:R-DME-214418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)
REACT:R-HSA-165033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multimerization of Rev (Homo sapiens)
RHEA:15899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + acetate => 4-acetamidobutanoate + H2O
RHEA:16331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2
REACT:R-MMU-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Mus musculus)
RHEA:63110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascofuranol => 16-hydroxy-ilicicolin A epoxide
REACT:R-SPO-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)
RHEA:63509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + O2 => a (2R)-2-hydroperoxy fatty acid
RHEA:70084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyclavatol => H2O + o-quinone methide
REACT:R-MMU-5682598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates HERC2 (Mus musculus)
RHEA:16167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + indole-3-acetamide => L-tryptophan + O2
REACT:R-MMU-5357828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8 (Mus musculus)
RHEA:58269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal glycine + NAD(+) => [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide
RHEA:51168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine
RHEA:37619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-RNO-6811504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)
RHEA:59177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + L-serine => AMP + H(+) + O-phospho-L-serine
RHEA:24305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) => (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2
REACT:R-XTR-8864307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Xenopus tropicalis)
RHEA:38393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-HSA-166792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C2 into C2a and C2b (Homo sapiens)
RHEA:58389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + all-trans-hexaprenyl diphosphate => 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate
REACT:R-BTA-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Bos taurus)
REACT:R-CFA-446701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)
RHEA:31486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol E + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP
REACT:R-RNO-177931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Rattus norvegicus)
RHEA:67330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trichosetin => (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione
REACT:R-DRE-433698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)
RHEA:43712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dodecanoate + H(+) = diphosphate + dodecanoyl-AMP
REACT:R-GGA-451505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)
GO:0047478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-ammonia ligase (ADP-forming) activity
GO:0047478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine synthetase (adenosine diphosphate-forming)
GO:0047478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine synthetase (ADP-forming) activity
GO:0047478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate:ammonia ligase (ADP-forming)
REACT:R-SSC-9011949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Sus scrofa)
RHEA:36766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-DRE-5690196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates RNF128 (Danio rerio)
GO:0042056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemoattractant activity
GO:0042056	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	attractant
REACT:R-GGA-5684875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR:ATRIP to RPA at resected DNA DSBs (Gallus gallus)
RHEA:35037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) => 4-aminobutanoate(in)
REACT:R-SSC-2468041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Sus scrofa)
RHEA:14929	skos:altLabel	"17-ketoreductase"
RHEA:14929	skos:prefLabel	"3alpha-(17beta)-hydroxysteroid dehydrogenase (NAD(+))"
RHEA:14929	skos:altLabel	"17beta-HSD"
RHEA:14929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH
RHEA:14929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha-(17beta)-hydroxysteroid dehydrogenase (NAD(+))"
REACT:R-CEL-5695980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD10 dehydrogenates S-2MPDA-CoA (Caenorhabditis elegans)
REACT:R-SPO-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Schizosaccharomyces pombe)
RHEA:57115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:31697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2
REACT:R-GGA-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Gallus gallus)
REACT:R-RNO-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Rattus norvegicus)
REACT:R-DME-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Drosophila melanogaster)
REACT:R-MMU-200396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Creatine transport across the plasma membrane (Mus musculus)
RHEA:28194	skos:prefLabel	"(S)-sulfolactate dehydrogenase"
RHEA:28194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-sulfolactate dehydrogenase"
RHEA:28194	skos:altLabel	"(2S)-3-sulfolactate dehydrogenase"
RHEA:28194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH
RHEA:18748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 juglone + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)
REACT:R-HSA-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Homo sapiens)
REACT:R-SSC-9625813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P binds S1PR3 in response to E2 stimulation (Sus scrofa)
REACT:R-GGA-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Gallus gallus)
REACT:R-MMU-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Mus musculus)
REACT:R-SSC-351863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active caspase-8 to the mitochondrial membrane (Sus scrofa)
RHEA:48096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine
RHEA:48096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"type I protein arginine methyltransferase"
RHEA:48096	skos:prefLabel	"type I protein arginine methyltransferase"
RHEA:42328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-DRE-392870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gs activation by prostacyclin receptor (Danio rerio)
REACT:R-HSA-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Homo sapiens)
REACT:R-GGA-2028670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Gallus gallus)
REACT:R-SSC-448963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of MyoD:E protein with MEF2 (Sus scrofa)
RHEA:20458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose + NAD(+) => D-arabinono-1,4-lactone + H(+) + NADH
RHEA:10714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetamide + CO2 + H2O => L-phenylalanine + O2
RHEA:59538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate
REACT:R-CFA-4084984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Canis familiaris)
REACT:R-DRE-111253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Danio rerio)
REACT:R-MMU-2327909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN binds collagen I, II, III, VI fibrils (Mus musculus)
REACT:R-DRE-163625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon binds to Glucagon receptor (Danio rerio)
REACT:R-DME-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Drosophila melanogaster)
RHEA:27945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-D-aspartate <=> NH4(+) + oxaloacetate
RHEA:10816	skos:altLabel	"almond emulsin fucosidase II"
RHEA:10816	skos:prefLabel	"1,2-alpha-L-fucosidase"
RHEA:10816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside
RHEA:10816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,2-alpha-L-fucosidase"
RHEA:62968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + NADP(+) = H(+) + NADPH + pyruvate
REACT:R-SSC-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)
REACT:R-SPO-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Schizosaccharomyces pombe)
GO:0102810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate-semialdehyde dehydrogenase (NADP+) activity
RHEA:35699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-versiconol + NADP(+) = (2S-3S)-versiconal hemiacetal + H(+) + NADPH
REACT:R-CEL-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Caenorhabditis elegans)
REACT:R-MMU-5672329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CLIP1 and microtubules (Mus musculus)
REACT:R-HSA-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Homo sapiens)
RHEA:28643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = alpha-zingiberene + diphosphate
RHEA:28643	skos:prefLabel	"zingiberene synthase"
RHEA:28643	skos:altLabel	"alpha-zingiberene synthase"
RHEA:28643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zingiberene synthase"
RHEA:28643	skos:altLabel	"ZIS"
RHEA:47158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH => 7alpha,25-dihydroxycholesterol + NAD(+)
REACT:R-HSA-2681667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Homo sapiens)
RHEA:34132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neryl diphosphate + olivetolate => cannabinerolate + diphosphate
RHEA:23881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate
REACT:R-CFA-389424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The orphan QRFP receptor can bind neuropeptide QRFP (Canis familiaris)
RHEA:23714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + pregnan-21-al => NADP(+) + pregnan-21-ol
REACT:R-MMU-8950269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Mus musculus)
REACT:R-XTR-2064406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Xenopus tropicalis)
REACT:R-DRE-5358343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT palmitoylates Hh N-terminal fragment (Danio rerio)
REACT:R-BTA-1234159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
REACT:R-BTA-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Bos taurus)
RHEA:41538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine
REACT:R-SCE-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Saccharomyces cerevisiae)
REACT:R-SSC-70920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Sus scrofa)
RHEA:55521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + 3 isopentenyl diphosphate => 3 diphosphate + nerylneryl diphosphate
GO:0009383	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	rRNA (cytosine-C5-967)-methyltransferase activity
GO:0009383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (cytosine-C5-)-methyltransferase activity
GO:0009383	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	rRNA m5C967 methyltransferase activity
REACT:R-RNO-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Rattus norvegicus)
REACT:R-XTR-8952382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 polyubiquitinates RUNX3 (Xenopus tropicalis)
REACT:R-CFA-158722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Canis familiaris)
RHEA:32729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain 3-oxoacyl-CoA + CO2 + CoA => a very-long-chain acyl-CoA + H(+) + malonyl-CoA
REACT:R-RNO-8854052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the SCF-FBXL7 complex (Rattus norvegicus)
RHEA:68012	skos:altLabel	"hypoxanthine-xanthine oxidase"
RHEA:68012	skos:altLabel	"xanthine oxidoreductase"
RHEA:68012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypoxanthine + O2 = H2O2 + xanthine
RHEA:68012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xanthine oxidase"
RHEA:68012	skos:altLabel	"Schardinger enzyme"
RHEA:68012	skos:prefLabel	"xanthine oxidase"
RHEA:68012	skos:altLabel	"hypoxanthine oxidase"
RHEA:37514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
REACT:R-CFA-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Canis familiaris)
REACT:R-RNO-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Rattus norvegicus)
REACT:R-GGA-5654416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:pFRS binds GRB2:SOS1 (Gallus gallus)
REACT:R-SSC-382553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA7:Apo1A-mediated phospholipid efflux (Sus scrofa)
REACT:R-DRE-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Danio rerio)
REACT:R-CFA-2213243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of COPII vesicle with Golgi complex (Canis familiaris)
RHEA:13673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[protein-PII] uridylyltransferase"
RHEA:13673	skos:altLabel	"uridylyl removing enzyme"
RHEA:13673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate
RHEA:13673	skos:altLabel	"PII uridylyl-transferase"
RHEA:13673	skos:prefLabel	"[protein-PII] uridylyltransferase"
REACT:R-CFA-190256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to FGF (Canis familiaris)
REACT:R-HSA-9009451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SMURF1 gene (Homo sapiens)
RHEA:49755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NAD(+) + proviolacein
REACT:R-XTR-2160851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAS1,2,3 mediate the polymerisation of HA (Xenopus tropicalis)
REACT:R-DDI-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Dictyostelium discoideum)
RHEA:45477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-DRE-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Danio rerio)
REACT:R-XTR-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Xenopus tropicalis)
REACT:R-HSA-9014129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEY1 gene expression is positively regulated by NOTCH3 and STAT1 (Homo sapiens)
RHEA:49475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose <=> H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP
REACT:R-SSC-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Sus scrofa)
RHEA:41993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH
RHEA:17524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) <=> ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate
REACT:R-CEL-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Caenorhabditis elegans)
RHEA:22474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + ADP + H(+) => (R)-pantetheine + ATP
RHEA:55548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine
REACT:R-DDI-376357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp7 associated Lysosome to Plasma membrane transport (Dictyostelium discoideum)
REACT:R-MMU-9727198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B exchanges K+ for H+ (Mus musculus)
REACT:R-CEL-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Caenorhabditis elegans)
RHEA:13884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + an aldehyde + H2O <=> a carboxylate + a quinol + H(+)
REACT:R-DRE-432164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Danio rerio)
GO:0102863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:3-2-18:1-phosphatidylcholine desaturase activity
REACT:R-HSA-2029270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLCgamma to membrane (Homo sapiens)
RHEA:38318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate <=> 3-hydroxybenzoate + pyruvate
REACT:R-MMU-2855125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-1 binds to molecular patterns on the target cell surface (Mus musculus)
RHEA:67073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acyl-CoA + H2O => a very long-chain fatty acid + CoA + H(+)
REACT:R-MMU-3318413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Mus musculus)
REACT:R-HSA-9727198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B exchanges K+ for H+ (Homo sapiens)
REACT:R-HSA-165692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)
REACT:R-HSA-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Homo sapiens)
RHEA:15484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + L-serine
REACT:R-DME-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Drosophila melanogaster)
REACT:R-GGA-2168079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL (GWL) phosphorylates ARPP19 (Gallus gallus)
REACT:R-MMU-8944263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type II (Mus musculus)
RHEA:32897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:32499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-sabinene 3-hydroxylase"
RHEA:32499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,5R)-sabinene + H(+) + NADPH + O2 = (1S,3R,5S)-sabinol + H2O + NADP(+)
RHEA:32499	skos:prefLabel	"(+)-sabinene 3-hydroxylase"
GO:0050047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S)-alpha-leucine 2,3-aminomutase activity
GO:0050047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucine 2,3-aminomutase activity
RHEA:57015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H2O + sulfite <=> a menaquinol + sulfate
GO:0035591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signalling adaptor activity
GO:0035591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling adaptor activity
GO:0035591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	signaling scaffold activity
GO:0035591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling protein recruiting activity
REACT:R-CEL-4719424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO1. (Caenorhabditis elegans)
RHEA:46166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + NADP(+) => a quinone + H(+) + NADPH
GO:0034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity
RHEA:62535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigitoxin + 2 Fe(III)-[cytochrome c]
REACT:R-DME-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Drosophila melanogaster)
REACT:R-DRE-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Danio rerio)
REACT:R-XTR-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Xenopus tropicalis)
REACT:R-CFA-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Canis familiaris)
REACT:R-XTR-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-SPO-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Schizosaccharomyces pombe)
RHEA:34573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + presqualene diphosphate => C30 botryococcene + diphosphate + NADP(+)
REACT:R-BTA-166869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MEKK1 (Bos taurus)
REACT:R-CEL-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)
REACT:R-BTA-76466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4A11 12-hydroxylates DDCX (Bos taurus)
REACT:R-XTR-8987230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Xenopus tropicalis)
RHEA:53933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-9733292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind pramlintide (Bos taurus)
RHEA:50766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine
GO:0015648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid-linked murein transporter activity
GO:0015648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid-linked peptidoglycan transporter activity
RHEA:40006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate <=> (Z)-biformene + diphosphate
RHEA:68619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + H(+) + NADPH <=> cortisol + NADP(+)
RHEA:42961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] => NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]
RHEA:56410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:65093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-1247497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds neuregulins (Danio rerio)
EC:3.2.1.57	skos:prefLabel	"isopullulanase"
EC:3.2.1.57	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopullulanase"
RHEA:12406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + lactose + UDP => D-glucose + UDP-alpha-D-galactose
REACT:R-GGA-9709883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB scavenges O2.- (Gallus gallus)
REACT:R-SPO-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Schizosaccharomyces pombe)
REACT:R-DME-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Drosophila melanogaster)
REACT:R-GGA-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Gallus gallus)
REACT:R-MMU-2046097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)
RHEA:11823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthamide-[translation elongation factor 2] + NAD(+) <=> H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide
RHEA:20624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Zn(2+)(in) <=> ADP + H(+) + phosphate + Zn(2+)(out)
RHEA:61785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allulose => keto-L-fructose
REACT:R-CEL-8875374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds LRIG1 (Caenorhabditis elegans)
REACT:R-XTR-197250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAMPT transfers PRIB to NAM to form NAMN (Xenopus tropicalis)
REACT:R-RNO-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Rattus norvegicus)
REACT:R-GGA-353056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Gallus gallus)
REACT:R-HSA-9617064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene (Homo sapiens)
REACT:R-BTA-6801666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates CENPJ (Bos taurus)
RHEA:16446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,4',7-trihydroxyisoflavanone => daidzein + H(+) + H2O
REACT:R-HSA-3700997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the MDM2 gene (Homo sapiens)
RHEA:31086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-muramoyl-L-alanine <=> L-alanine + N-acetyl-D-muramate
RHEA:35449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + norsolorinic acid => (1'S)-averantin + NADP(+)
REACT:R-RNO-981497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Rattus norvegicus)
REACT:R-SSC-927832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
REACT:R-HSA-5660662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASC binds Caspase-8 complex (Homo sapiens)
REACT:R-DME-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Drosophila melanogaster)
REACT:R-SCE-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Saccharomyces cerevisiae)
REACT:R-DRE-77592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Intronless Pre-mRNA at 3'-end (Danio rerio)
REACT:R-DME-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Drosophila melanogaster)
RHEA:31412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
RHEA:38560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate => (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CFA-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Canis familiaris)
RHEA:72184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine(in) + H(+)(out) => creatinine(out) + H(+)(in)
REACT:R-HSA-166538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The bound receptor dimerizes (Homo sapiens)
GO:0033443	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine tRNA
GO:0033443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAA codon-amino acid adaptor activity
REACT:R-DRE-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Danio rerio)
GO:0140666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	renaturation
GO:0140666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	annealing activity
RHEA:68461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a phenolic steroid => a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-DRE-8877941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SMAD1 in the nucleus (Danio rerio)
REACT:R-DRE-177107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion and activation of the latent large complex of TGF-beta-1 (Danio rerio)
REACT:R-DME-174097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdh1 (Drosophila melanogaster)
REACT:R-HSA-8986083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates ROBO1 (Homo sapiens)
REACT:R-MMU-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Mus musculus)
REACT:R-CFA-6809006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)
REACT:R-BTA-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Bos taurus)
REACT:R-RNO-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Rattus norvegicus)
REACT:R-SSC-5666129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP recruits DIAPH2-2 to kinetochores (Sus scrofa)
REACT:R-PFA-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Plasmodium falciparum)
REACT:R-BTA-2130504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of lip22 to lip10 (Bos taurus)
RHEA:34221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+)
REACT:R-HSA-5323545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canonical WNT signaling through the atypical receptor RYK (Homo sapiens)
REACT:R-HSA-420883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins act as GEFs for G alpha-t (Homo sapiens)
REACT:R-XTR-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Xenopus tropicalis)
RHEA:27308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline-2-carboxylate + AH2 => A + D-proline
RHEA:12682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine + H(+) + H2O => N-methylhydantoin + NH4(+)
REACT:R-SSC-450325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-FOS activation by phospho ERK1/2 (Sus scrofa)
REACT:R-HSA-2161668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGA2 is dehydrated to 15d-PGA2 (Homo sapiens)
RHEA:43644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + tetradecanoyl-CoA = 3-oxohexadecanoyl-[ACP] + CO2 + CoA
REACT:R-GGA-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Gallus gallus)
REACT:R-DRE-8851352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR8 binds CCL1 (Danio rerio)
REACT:R-GGA-141423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the MCC complex to the APC/C complex (Gallus gallus)
REACT:R-SSC-8944266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XI (Sus scrofa)
REACT:R-CFA-9024997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Canis familiaris)
REACT:R-SPO-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Schizosaccharomyces pombe)
REACT:R-GGA-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Gallus gallus)
RHEA:46312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + acetyl-CoA = 3,22-dioxochol-4-en-24-oyl-CoA + CoA
REACT:R-HSA-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Homo sapiens)
REACT:R-CFA-74712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of IRS-P from insulin receptor (Canis familiaris)
REACT:R-CFA-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Canis familiaris)
RHEA:66728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate
REACT:R-HSA-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Homo sapiens)
REACT:R-BTA-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Bos taurus)
REACT:R-GGA-351407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of MRE11 with RAD50 (Gallus gallus)
RHEA:71080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] => cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-1678716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(1) (Bos taurus)
REACT:R-CEL-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Caenorhabditis elegans)
REACT:R-DDI-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Dictyostelium discoideum)
REACT:R-DME-8857925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Drosophila melanogaster)
REACT:R-SSC-194308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Sus scrofa)
REACT:R-CFA-5696968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP20, USP33 deubiquitinate ADRB2 (Canis familiaris)
RHEA:56808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] = adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate
REACT:R-MMU-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Mus musculus)
REACT:R-HSA-400063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Low conductance potassium channels in pancreatic beta cells open in response to epinephrine (Homo sapiens)
RHEA:39420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)
REACT:R-GGA-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Gallus gallus)
REACT:R-MMU-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Mus musculus)
REACT:R-DRE-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Danio rerio)
RHEA:63321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid(in) + ATP + H2O => a glycerophospholipid(out) + ADP + H(+) + phosphate
RHEA:32529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine => N,N'-diacetylchitobiose + phosphate
REACT:R-HSA-5607745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG (Homo sapiens)
REACT:R-CFA-5082384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70:DNAJB1 binds HSF1 (Canis familiaris)
REACT:R-MMU-216043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II binds integrin alpha10beta1 (Mus musculus)
RHEA:50016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine
RHEA:33606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-hexacosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)
RHEA:50416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)
RHEA:64152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)
RHEA:62786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bifonsecin B + 2 H2O + NADP(+) => 2 fonsecin B + H(+) + NADPH + O2
REACT:R-MMU-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Mus musculus)
REACT:R-SSC-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Sus scrofa)
RHEA:30068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H2O + NADP(+) => glycine betaine + 2 H(+) + NADPH
REACT:R-XTR-909722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-STAT2:p-STAT1 dimer (Xenopus tropicalis)
REACT:R-HSA-2671839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT3 Dissociates from Leptin Receptor (Homo sapiens)
RHEA:56389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
REACT:R-RNO-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Rattus norvegicus)
RHEA:32954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose <=> trehalulose
RHEA:29780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-methionine(out) => ADP + H(+) + L-methionine(in) + phosphate
REACT:R-DDI-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Dictyostelium discoideum)
RHEA:17810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-protoporphyrin IX + S-adenosyl-L-methionine => Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine
REACT:R-CFA-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)
RHEA:46378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-RNO-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Rattus norvegicus)
REACT:R-RNO-1655842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)
REACT:R-HSA-184323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of N-myristoyl GAG polyprotein (Homo sapiens)
RHEA:24068	skos:altLabel	"cyclohexanone 1,2-monooxygenase"
RHEA:24068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexanone monooxygenase"
RHEA:24068	skos:altLabel	"cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing)"
RHEA:24068	skos:altLabel	"cyclohexanone oxygenase"
RHEA:24068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanone + H(+) + NADPH + O2 = H2O + hexano-6-lactone + NADP(+)
RHEA:24068	skos:prefLabel	"cyclohexanone monooxygenase"
RHEA:38639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-DRE-192312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Danio rerio)
REACT:R-BTA-110351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of SMUG1 glycosylase by APEX1 at the AP site (Bos taurus)
GO:0051721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein phosphatase 2 binding
GO:0051721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphatase 2A binding
RHEA:64601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base
REACT:R-HSA-9619515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates MAPT (Homo sapiens)
REACT:R-DME-77277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Drosophila melanogaster)
RHEA:36999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:49408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-mannosyl](n) + phosphate = [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate
RHEA:49408	skos:prefLabel	"1,2-beta-oligomannan phosphorylase"
RHEA:49408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,2-beta-oligomannan phosphorylase"
REACT:R-CFA-180038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Canis familiaris)
REACT:R-BTA-5685953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates RBBP8 (Bos taurus)
GO:0019766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgA receptor activity
REACT:R-BTA-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Bos taurus)
RHEA:37406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA
REACT:R-RNO-3927824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CASP8AP2 with SUMO1 (Rattus norvegicus)
RHEA:27848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+) => (2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2
REACT:R-DRE-3149539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Danio rerio)
REACT:R-SSC-5653974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator binds Rag dimers (Sus scrofa)
REACT:R-BTA-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Bos taurus)
REACT:R-GGA-4570499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Gallus gallus)
REACT:R-SSC-8933328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYPLA2 hydrolyses PALM-C3,4-GAP43 (Sus scrofa)
RHEA:41044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA
RHEA:46268	skos:altLabel	"8-sphingolipid desaturase"
RHEA:46268	skos:prefLabel	"sphingolipid 8-(E/Z)-desaturase"
RHEA:46268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingolipid 8-(E/Z)-desaturase"
RHEA:46268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46268	skos:altLabel	"8 fatty acid desaturase"
REACT:R-HSA-2584246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)
REACT:R-XTR-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Xenopus tropicalis)
REACT:R-DRE-193845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
RHEA:71129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-glutamine(in) + Na(+)(in) => H(+)(in) + L-glutamine(out) + Na(+)(out)
REACT:R-MMU-389995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Mus musculus)
REACT:R-MMU-193995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 18-hydroxylates CORST to 18HCORST (Mus musculus)
RHEA:18140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADPH
REACT:R-GGA-9679421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCD1 binds PDCD1 inhibitors (Gallus gallus)
REACT:R-HSA-9663363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)
RHEA:16960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP + H2O <=> GMP + H(+)
REACT:R-MMU-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Mus musculus)
RHEA:46978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-N-methylmyosmine + H2O2 => (S)-6-hydroxynicotine + O2
RHEA:23501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) => 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:55166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+) => a jasmonyl-L-isoleucinate + H(+) + NADPH + O2
RHEA:18559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA
REACT:R-RNO-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Rattus norvegicus)
REACT:R-SSC-8875451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates CBL (Sus scrofa)
REACT:R-DDI-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Dictyostelium discoideum)
RHEA:37873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+) => 2-heptyl-4(1H)-quinolone + H(+) + NADH + O2
REACT:R-DME-977348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHGDH tetramer dehydrogenates 3PG (Drosophila melanogaster)
REACT:R-MMU-9724685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds omalizumab (Mus musculus)
EC:3.4.21.65	skos:altLabel	"thermomycolase"
EC:3.4.21.65	skos:prefLabel	"thermomycolin"
EC:3.4.21.65	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thermomycolin"
REACT:R-HSA-5665686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL1 binds CDC42:GTP (Homo sapiens)
REACT:R-GGA-353313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of 3'-phosphoglycolate (PG) moiety from DSB ends (Gallus gallus)
RHEA:12065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxopentanoate + H2O + NAD(+) => glutarate + 2 H(+) + NADH
REACT:R-SCE-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Saccharomyces cerevisiae)
RHEA:59423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylamine + O2 <=> formaldehyde + H2O2 + NH4(+)
REACT:R-DME-4084976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)
REACT:R-CFA-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)
RHEA:26472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-feruloyloxyhexadecanoate + CoA => (E)-feruloyl-CoA + 16-hydroxyhexadecanoate
RHEA:69948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> delta-cadinene + diphosphate
RHEA:29345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate(out) + succinate(in) => L-aspartate(in) + succinate(out)
REACT:R-CFA-6800380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAP-1 (Canis familiaris)
REACT:R-CEL-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Caenorhabditis elegans)
REACT:R-DME-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)
REACT:R-GGA-975916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 5 by MGAT5 (Gallus gallus)
RHEA:66601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dopamine + O2 => 2 dopamine quinone + 2 H2O
RHEA:70681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(out) + H(+)(out) => glycine betaine(in) + H(+)(in)
EC:1.14.14.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aromatic aldoxime N-monooxygenase"
EC:1.14.14.45	skos:altLabel	"CYP83B1"
EC:1.14.14.45	skos:prefLabel	"aromatic aldoxime N-monooxygenase"
RHEA:27781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) <=> 2-all-trans-octaprenylphenol + CO2
RHEA:57051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]
GO:0010331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin binding
GO:0010331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gibberellin receptor
GO:0010331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gibberellic acid receptor
RHEA:22822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose
GO:0004378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
GO:0004378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose-oligosaccharide-lipid mannosyltransferase II
GO:0004378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity
GO:0004378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity
GO:0004378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity
GO:0004378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosyltransferase II activity
GO:0004378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolipid 3-alpha-mannosyltransferase activity
REACT:R-HSA-156912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)
GO:0103032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH
GO:0103032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tartronate semialdehyde reductase activity
REACT:R-SPO-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Schizosaccharomyces pombe)
REACT:R-DRE-139905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAD protein to mitochondria (Danio rerio)
REACT:R-SSC-177923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sustained activation of SRC kinase by SHP2 (Sus scrofa)
RHEA:15549	skos:prefLabel	"methylthioribulose 1-phosphate dehydratase"
RHEA:15549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylthioribulose 1-phosphate dehydratase"
RHEA:15549	skos:altLabel	"1-PMT-ribulose dehydratase"
RHEA:15549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O
REACT:R-SCE-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)
EC:1.6.5.10	skos:prefLabel	"NADPH dehydrogenase (quinone)"
EC:1.6.5.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADPH dehydrogenase (quinone)"
REACT:R-CFA-202478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction and oligomerization of MALT1 to Bcl10 (Canis familiaris)
REACT:R-XTR-8851352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR8 binds CCL1 (Xenopus tropicalis)
RHEA:32002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> bicyclogermacrene + diphosphate
GO:0140663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent FeS chaperone activity
RHEA:72343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol
RHEA:10935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + L-citrulline <=> 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
GO:0102483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scopolin beta-glucosidase activity
RHEA:44462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol
REACT:R-CEL-3229181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALM1:Ca2+ binds CNG channel (Caenorhabditis elegans)
REACT:R-HSA-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Homo sapiens)
GO:0019170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylglyoxal reductase activity
GO:0019170	skos:altLabel	"methylglyoxal reductase"
GO:0019170	skos:altLabel	"methylglyoxal reductase (NADH-dependent)"
GO:0019170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylglyoxal reductase (NADH)"
GO:0019170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-lactaldehyde:NAD+ oxidoreductase activity
GO:0019170	skos:prefLabel	"methylglyoxal reductase (NADH)"
GO:0019170	skos:altLabel	"D-lactaldehyde dehydrogenase"
GO:0019170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylglyoxal reductase (NADH-dependent) activity
GO:0019170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lactaldehyde dehydrogenase activity
GO:0019170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactaldehyde + NAD(+) = H(+) + methylglyoxal + NADH
REACT:R-HSA-5662599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1M binds cadmium (Homo sapiens)
REACT:R-DDI-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Dictyostelium discoideum)
REACT:R-DDI-6809015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Dictyostelium discoideum)
REACT:R-CEL-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Caenorhabditis elegans)
REACT:R-BTA-9038052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GREB1 binds ESR1:ESTG and co-activators (Bos taurus)
REACT:R-XTR-5690196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates RNF128 (Xenopus tropicalis)
RHEA:65200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(acetaldehyde)-L-cysteine = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O
REACT:R-CFA-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Canis familiaris)
REACT:R-BTA-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Bos taurus)
REACT:R-DRE-5603114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)
REACT:R-MMU-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Mus musculus)
REACT:R-HSA-9734535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Homo sapiens)
REACT:R-CFA-3134954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX9 binds DNA (Canis familiaris)
REACT:R-SCE-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Saccharomyces cerevisiae)
RHEA:71608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + phosphate(out) => (S)-malate(out) + phosphate(in)
REACT:R-HSA-2993780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO1 from E1 to UBE2I (UBC9) (Homo sapiens)
RHEA:35410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + medicarpin <=> 4'-methoxyisoflavan-2',4,7-triol
RHEA:39606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA <=> (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O
REACT:R-RNO-9653595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B binds BCL2L1 (Rattus norvegicus)
RHEA:43729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]
RHEA:38446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + a long chain fatty alcohol <=> a wax ester + CoA
RHEA:17837	skos:prefLabel	"2-carboxy-D-arabinitol-1-phosphatase"
RHEA:17837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate
RHEA:17837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-carboxy-D-arabinitol-1-phosphatase"
GO:0047938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-6-phosphate 1-epimerase activity
GO:0047938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose-6-phosphate 1-epimerase activity
GO:0047938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-6 phosphate 1-epimerase activity
RHEA:65156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + preaustinoid A2 = CO2 + H2O + preaustinoid A3 + succinate
REACT:R-PFA-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)
GO:0004755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	saccharopine reductase activity
GO:0004755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)
GO:0004755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoadipate semialdehyde-glutamate reductase activity
GO:0004755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoadipic semialdehyde-glutamic reductase activity
GO:0004755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity
GO:0004755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
GO:0004755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity
GO:0004755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoadipic semialdehyde-glutamate reductase activity
GO:0004755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
REACT:R-DDI-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Dictyostelium discoideum)
REACT:R-HSA-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Homo sapiens)
RHEA:60428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-L-aspartate + H2O = (indol-3-yl)acetate + L-aspartate
RHEA:60428	skos:prefLabel	"(indol-3-yl)acetyl-L-aspartate hydrolase"
RHEA:60428	skos:altLabel	"indole-3-acetyl-L-aspartate hydrolase"
RHEA:60428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(indol-3-yl)acetyl-L-aspartate hydrolase"
GO:0018549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MT-oxidase activity
GO:0018549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanethiol oxidase activity
GO:0018549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methyl mercaptan oxidase activity
GO:0018549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide
GO:0018549	skos:altLabel	"methylmercaptan oxidase"
GO:0018549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmercaptan oxidase activity
GO:0018549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methanethiol:oxygen oxidoreductase activity
GO:0018549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methanethiol oxidase"
GO:0018549	skos:prefLabel	"methanethiol oxidase"
GO:0018549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(MM)-oxidase activity
REACT:R-HSA-9732822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3 binds to PLpro inhibitors (Homo sapiens)
REACT:R-MMU-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Mus musculus)
RHEA:14446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
GO:0050833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPC1:MPC2 cotransports PYR, H+ from cytosol to mitochondrial matrix (Homo sapiens)
GO:0050833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate transmembrane transporter activity
GO:0050833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
REACT:R-DRE-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)
REACT:R-BTA-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Bos taurus)
REACT:R-SSC-266299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds membrane-associated free cholesterol and phospholipids (Sus scrofa)
REACT:R-PFA-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Plasmodium falciparum)
REACT:R-HSA-351210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Homo sapiens)
REACT:R-RNO-5419273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of GTP and dissociation of 28S and 39S subunits (Rattus norvegicus)
REACT:R-RNO-3928645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB:NMDAR binds TIAM1 (Rattus norvegicus)
RHEA:46040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + ATP = ADP + dCMP + H(+)
REACT:R-BTA-3000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BORA binds PLK1 and AURKA (Bos taurus)
REACT:R-DRE-191983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
REACT:R-BTA-8850818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK9 binds KLK5 (Bos taurus)
RHEA:47791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 28S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine
GO:0008927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	altronic hydro-lyase activity
GO:0008927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannonate hydro-lyase activity
GO:0008927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannonic hydrolase activity
GO:0008927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannonate hydrolyase activity
GO:0008927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)
GO:0008927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannonate dehydratase activity
GO:0008927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	altronate hydrolase activity
GO:0008927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannonate hydrolyase activity
REACT:R-SSC-9677929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB inhibitors bind MAOB:FAD (Sus scrofa)
REACT:R-MMU-450422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP recruits RNA degradation activities (Mus musculus)
REACT:R-SSC-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Sus scrofa)
RHEA:46262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-DME-9691566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 binds nicorandil (Drosophila melanogaster)
RHEA:49261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] => D-galactose 6-phosphate(in) + L-histidyl-[protein]
REACT:R-DRE-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Danio rerio)
REACT:R-HSA-4551604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO1 (Homo sapiens)
REACT:R-HSA-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)
RHEA:12000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate dehydrogenase (NADP(+))"
RHEA:12000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + NADP(+) = CO2 + NADPH
RHEA:12000	skos:prefLabel	"formate dehydrogenase (NADP(+))"
RHEA:70002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine(in) + Na(+)(in) <=> L-threonine(out) + Na(+)(out)
REACT:R-HSA-177937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of EGFR by SRC kinase (Homo sapiens)
GO:0018814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OxdB
GO:0018814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity
GO:0018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetaldoxime dehydratase activity
GO:0018814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAOx dehydratase activity
GO:0018814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(Z)-phenylacetaldehyde-oxime hydro-lyase activity
GO:0018814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylacetaldoxime dehydratase activity
REACT:R-DDI-5610733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Dictyostelium discoideum)
REACT:R-XTR-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Xenopus tropicalis)
RHEA:63000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)-eicosatrienoate + NH4(+)
GO:0047046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity
GO:0047046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-3-carboxyadipate dehydrogenase activity
GO:0047046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
GO:0047046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2-hydroxyadipate dehydrogenase activity
GO:0047046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)
GO:0047046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity
GO:0047046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homoisocitrate dehydrogenase activity
GO:0047046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoisocitric dehydrogenase activity
GO:0047046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)
RHEA:45951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]
REACT:R-RNO-9614271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ADGRG6 (Rattus norvegicus)
REACT:R-HSA-74994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box (Homo sapiens)
REACT:R-CFA-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Canis familiaris)
RHEA:23630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose
REACT:R-XTR-9014074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin4 (Xenopus tropicalis)
RHEA:14048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-carboxyvinyl carboxyphosphonate + H(+) <=> 3-(hydrohydroxyphosphoryl)pyruvate + CO2
REACT:R-SSC-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Sus scrofa)
RHEA:21756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylisoipecoside + H2O = dopamine + secologanin
RHEA:21756	skos:prefLabel	"deacetylisoipecoside synthase"
RHEA:21756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deacetylisoipecoside synthase"
REACT:R-BTA-2530445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD59 inhibits MAC formation (Bos taurus)
RHEA:64662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]
RHEA:12519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-(R)-germacrene A + diphosphate
RHEA:12927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => D-erythrose 4-phosphate + L-lysyl-[protein]
RHEA:13502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] => ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate
REACT:R-MMU-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)
RHEA:19704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-glycoside + UDP-alpha-D-xylose <=> a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP
RHEA:42499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate <=> 10-deacetyl-2-debenzoylbaccatin III
RHEA:41724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-2404200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2 binds IGF1R (Rattus norvegicus)
RHEA:38250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + hexadecan-1-ol <=> 1-O-hexadecyl (9Z)-hexadecenoate + CoA
REACT:R-RNO-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Rattus norvegicus)
GO:0047061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose:D-fructose oxidoreductase activity
GO:0047061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-fructose oxidoreductase activity
REACT:R-CEL-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Caenorhabditis elegans)
REACT:R-GGA-2213240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of disulphide bonds in MHC II antigens (Gallus gallus)
RHEA:35064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyrazinamide => NH4(+) + pyrazine-2-carboxylate
RHEA:60633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-oxoretinol + NAD(+) => all-trans-4-oxoretinal + H(+) + NADH
REACT:R-GGA-8937989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRC1 complexes (Gallus gallus)
REACT:R-HSA-1006169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds host cell surface markers (Homo sapiens)
REACT:R-DDI-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Dictyostelium discoideum)
REACT:R-SSC-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Sus scrofa)
GO:0052903	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N(1)-acetylpolyamine oxidase activity
GO:0052903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052903	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	non-specific polyamine oxidase activity
GO:0052903	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyamine oxidase activity
REACT:R-CEL-1602398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Caenorhabditis elegans)
REACT:R-MMU-8948027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial phospholipids (Mus musculus)
REACT:R-BTA-390835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD1,5 bind DA (Bos taurus)
GO:0022857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uptake permease activity
GO:0022857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Homo sapiens)
GO:0022857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane transporter activity
GO:0022857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	substrate-specific transporter activity
GO:0022857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uptake transmembrane transporter activity
GO:0022857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	substrate-specific transmembrane transporter activity
REACT:R-XTR-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Xenopus tropicalis)
RHEA:37394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
GO:0033863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PhnN
GO:0033863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:ribose-1,5-bisphosphate phosphotransferase activity
GO:0033863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 1,5-bisphosphate phosphokinase activity
GO:0033863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribose 1,5-bisphosphokinase activity
REACT:R-GGA-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Gallus gallus)
RHEA:64204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-SSC-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Sus scrofa)
REACT:R-DRE-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Danio rerio)
REACT:R-HSA-9011952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Homo sapiens)
REACT:R-HSA-9755252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp15 cleaves viral poly(U)-RNA (Homo sapiens)
REACT:R-GGA-8851797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 in ADRB2:GRK complex is phosphorylated (Gallus gallus)
REACT:R-MMU-9687638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds IP4, IP5 and IP6  (Mus musculus)
RHEA:32077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-ol + diphosphate => geranylgeranyl diphosphate + H2O
REACT:R-CEL-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Caenorhabditis elegans)
REACT:R-DME-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Drosophila melanogaster)
REACT:R-HSA-9615023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLXNA4 gene expression is stimulated by FOXO6 (Homo sapiens)
REACT:R-RNO-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Rattus norvegicus)
REACT:R-BTA-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Bos taurus)
REACT:R-RNO-419334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melatonin receptors can bind melatonin (Rattus norvegicus)
REACT:R-DME-1295621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
RHEA:13379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-glucose 1,6-bisphosphate + H(+) => alpha-D-glucose 1-phosphate + ATP
REACT:R-SCE-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Saccharomyces cerevisiae)
REACT:R-SCE-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Saccharomyces cerevisiae)
REACT:R-RNO-2187355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters phosphorylated SMAD2/3 (Rattus norvegicus)
RHEA:58754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH
REACT:R-BTA-193064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3-like proteins reducde ANDST to TEST (Bos taurus)
RHEA:13468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + oxalyl-CoA <=> CoA + N(3)-oxalyl-L-2,3-diaminopropanoate
REACT:R-DRE-112042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid binds MOR (Danio rerio)
REACT:R-XTR-2395965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Xenopus tropicalis)
REACT:R-BTA-2243926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of histidino-hydroxylysinonorleucine cross-links (Bos taurus)
RHEA:11483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)
RHEA:47468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-tetradecadienoyl-CoA = (3E,5Z)-tetradecadienoyl-CoA
REACT:R-SSC-5696213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to methylarsonite (Sus scrofa)
RHEA:40395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)
GO:0008923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine carboxy-lyase activity
GO:0008923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine carboxy-lyase (cadaverine-forming)
GO:0008923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine decarboxylase activity
REACT:R-DDI-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Dictyostelium discoideum)
REACT:R-DDI-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)
REACT:R-SSC-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Sus scrofa)
REACT:R-RNO-8869568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM1 binds TFAP2A homodimer (Rattus norvegicus)
GO:0032051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clathrin light chain binding
REACT:R-PFA-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Plasmodium falciparum)
RHEA:67339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 3-O-beta-D-glucoside + malonyl-CoA <=> CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)
REACT:R-RNO-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Rattus norvegicus)
REACT:R-BTA-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Bos taurus)
REACT:R-DME-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)
REACT:R-HSA-5205824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)
RHEA:56649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-24-oyl-CoA + NAD(+) => 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH
GO:0015422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type oligosaccharide transporter"
GO:0015422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled oligosaccharide transmembrane transporter activity
GO:0015422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type oligosaccharide transporter activity
GO:0015422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharide ABC transporter
GO:0015422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ABC-type oligosaccharide transporter
GO:0015422	skos:prefLabel	"ABC-type oligosaccharide transporter"
GO:0015422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligosaccharide-transporting ATPase activity
GO:0015422	skos:altLabel	"oligosaccharide-transporting ATPase"
GO:0015422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent oligosaccharide transmembrane transporter activity
REACT:R-XTR-73912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Xenopus tropicalis)
RHEA:32469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + sarcosine
RHEA:59593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-arginine => ADP + beta-alanyl-L-arginine + H(+) + phosphate
REACT:R-DRE-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Danio rerio)
RHEA:46703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate + GTP + H(+) <=> (R)-lipoyl-GMP + diphosphate
RHEA:26502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + UDP
REACT:R-HSA-3640858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase ADP-ribosylates AXIN (Homo sapiens)
REACT:R-SSC-6799466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 dimerizes (Sus scrofa)
REACT:R-MMU-182988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty lures CBL away from EGFR (Mus musculus)
RHEA:66652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = african-1-ene + diphosphate
RHEA:11274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + a quinol => a (2R)-2-hydroxycarboxylate + a quinone
REACT:R-XTR-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Xenopus tropicalis)
RHEA:59810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tyrosine => L-tyrosine
RHEA:68321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,4,5-triphosphate + H2O => 1D-myo-inositol 2,5-bisphosphate + phosphate
EC:3.4.21.98	skos:prefLabel	"hepacivirin"
EC:3.4.21.98	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hepacivirin"
EC:3.4.21.98	skos:altLabel	"Cpro-2"
EC:3.4.21.98	skos:altLabel	"hepatitis C virus NS3 serine proteinase"
RHEA:39935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
RHEA:48052	skos:altLabel	"CHST14 protein"
RHEA:48052	skos:prefLabel	"dermatan 4-sulfotransferase"
RHEA:48052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dermatan 4-sulfotransferase"
RHEA:48052	skos:altLabel	"dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase"
RHEA:48052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + dermatan = n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)
RHEA:48052	skos:altLabel	"dermatan N-acetylgalactosamine 4-O-sulfotransferase"
RHEA:62431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA
RHEA:43452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA
RHEA:17800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)
RHEA:66498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate
REACT:R-XTR-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Xenopus tropicalis)
REACT:R-HSA-5629187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds regulatory elements of SESN1,2,3 genes (Homo sapiens)
REACT:R-HSA-9612514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S133 CREB and p-S103 SRF bind the EGR1 promoter (Homo sapiens)
REACT:R-XTR-2029453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of VAV (Xenopus tropicalis)
RHEA:49789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + glycine => CoA + glycochenodeoxycholate + H(+)
RHEA:37288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-leucine(out) => ADP + H(+) + L-alanyl-L-leucine(in) + phosphate
RHEA:11811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bergaptol + S-adenosyl-L-methionine <=> bergapten + S-adenosyl-L-homocysteine
REACT:R-HSA-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)
REACT:R-MMU-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Mus musculus)
RHEA:24289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formimidoyltetrahydrofolate + glycine => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine
REACT:R-DME-6799191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Drosophila melanogaster)
RHEA:63657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-BTA-190385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3b (Bos taurus)
RHEA:67833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate
RHEA:45304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine
REACT:R-GGA-8950410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B:IL12B translocates from ER lumen to the extracellular region (Gallus gallus)
REACT:R-HSA-1482860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL transports from the IM to the ER (Homo sapiens)
REACT:R-HSA-2176416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)
REACT:R-SSC-5610763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Sus scrofa)
REACT:R-RNO-4086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO2,3 (Rattus norvegicus)
REACT:R-GGA-2453876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTR:RBP:atROL binds to STRA6 receptor (Gallus gallus)
RHEA:19694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH
REACT:R-MMU-201634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of FADK 1 (Mus musculus)
REACT:R-DRE-399933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sema3A binds Nrp-1 bound to PlexinA (Danio rerio)
REACT:R-BTA-193713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Bos taurus)
REACT:R-MMU-1678998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosomal TLRs pass through the Golgi (Mus musculus)
RHEA:59099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoglucosyl-enterobactin + UDP-alpha-D-glucose <=> diglucosyl-enterobactin + H(+) + UDP
REACT:R-RNO-8982163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Rattus norvegicus)
REACT:R-XTR-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Xenopus tropicalis)
RHEA:13409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH
RHEA:13409	skos:altLabel	"preQ0 reductase"
RHEA:13409	skos:altLabel	"7-cyano-7-deazaguanine reductase"
RHEA:13409	skos:prefLabel	"preQ1 synthase"
RHEA:13409	skos:altLabel	"preQ0 oxidoreductase"
RHEA:13409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"preQ1 synthase"
RHEA:17577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose
RHEA:17577	skos:prefLabel	"ADP-glyceromanno-heptose 6-epimerase"
RHEA:17577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-glyceromanno-heptose 6-epimerase"
RHEA:17577	skos:altLabel	"ADP-L-glycero-D-manno-heptose 6-epimerase"
RHEA:24814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-valine => 3-methyl-2-oxobutanoate + L-glutamate
REACT:R-DRE-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Danio rerio)
REACT:R-BTA-374922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenalin synaptic vesicle docking and priming (Bos taurus)
REACT:R-MMU-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Mus musculus)
RHEA:10255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + O-phospho-L-serine <=> L-cysteine + phosphate
REACT:R-HSA-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Homo sapiens)
REACT:R-HSA-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Homo sapiens)
REACT:R-CFA-196857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK2 phosphorylates PanK (Canis familiaris)
RHEA:65656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cholest-1,4-dien-3-one + H2O = 25-hydroxycholest-1,4-dien-3-one + AH2
REACT:R-CEL-6791219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Caenorhabditis elegans)
GO:0030734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylpolysacharide 6-methyltransferase activity
GO:0030734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polysaccharide methyltransferase activity
GO:0030734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polysaccharide O-methyltransferase activity
GO:0030734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity
RHEA:31212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-selenomethionine => diphosphate + L-adenosylselenomethionine + phosphate
REACT:R-BTA-9008285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Bos taurus)
REACT:R-DDI-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Dictyostelium discoideum)
REACT:R-SPO-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Schizosaccharomyces pombe)
RHEA:51549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-tetrahydropapaverine + S-adenosyl-L-methionine => (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine
RHEA:40332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-XTR-9033520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves TYSND1 (Xenopus tropicalis)
REACT:R-MMU-74746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y427-SHC1 (Mus musculus)
REACT:R-HSA-177934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR autophosphorylation (Homo sapiens)
REACT:R-DDI-450173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 induces oligomerisation of TRAF6 (Dictyostelium discoideum)
REACT:R-RNO-8944218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VIII (Rattus norvegicus)
RHEA:35577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-5687183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKDC phosphorylates DCLRE1C at DNA DSBs (Canis familiaris)
GO:0050596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vinorine hydroxylase activity
GO:0050596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)
REACT:R-SPO-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Schizosaccharomyces pombe)
REACT:R-HSA-5693644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)
RHEA:48875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a gentamycin + GTP <=> a gentamycin 2''-phosphate + GDP + H(+)
REACT:R-RNO-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Rattus norvegicus)
REACT:R-DME-9010815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLITs bind keratan sulfate (Drosophila melanogaster)
REACT:R-CEL-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Caenorhabditis elegans)
REACT:R-MMU-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
REACT:R-HSA-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Homo sapiens)
RHEA:22919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-hydroxyacetophenone + H(+) + NADPH + O2 <=> 4-acetoxyphenol + H2O + NADP(+)
EC:4.1.1.1	skos:altLabel	"2-oxo-acid carboxy-lyase"
EC:4.1.1.1	skos:altLabel	"pyruvic decarboxylase"
EC:4.1.1.1	skos:altLabel	"alpha-ketoacid carboxylase"
EC:4.1.1.1	skos:prefLabel	"pyruvate decarboxylase"
EC:4.1.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate decarboxylase"
EC:4.1.1.1	skos:altLabel	"alpha-carboxylase"
GO:0050073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:macrolide 2'-O-phosphotransferase activity
GO:0050073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrolide 2'-kinase activity
REACT:R-GGA-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Gallus gallus)
RHEA:32665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine => 5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine
REACT:R-MMU-751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gz complex dissociates (Mus musculus)
RHEA:32085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-pseudaminate + diphosphate => CTP + pseudaminate
REACT:R-HSA-9006323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-JAK2 phosphorylates EPOR (Homo sapiens)
RHEA:62907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)
RHEA:39005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O
RHEA:39064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + scyllo-inositol => H(+) + NADPH + scyllo-inosose
GO:0050456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cystine reductase (NADH2)
GO:0050456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine:NAD+ oxidoreductase
GO:0050456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dependent cystine reductase activity
GO:0050456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cystine reductase activity
GO:0050456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cystine reductase (NADH) activity
GO:0050456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:L-cystine oxidoreductase activity
GO:0050456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2:L-cystine oxidoreductase
REACT:R-RNO-372705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
REACT:R-MMU-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Mus musculus)
REACT:R-CFA-176700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Canis familiaris)
REACT:R-GGA-8857549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HBEGF-bound EGFR forms a heterodimer with GPNMB (Gallus gallus)
RHEA:15577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + uridine = D-ribose + uracil
REACT:R-GGA-749448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)
REACT:R-SSC-8878143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SMAD3 and SMAD4 (Sus scrofa)
RHEA:65517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O => NH4(+) + pre-mycofactocin
RHEA:17166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-D-galactose
RHEA:65811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:11842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + 2 H(+) + NADH => benzaldehyde + H2O + NAD(+)
RHEA:38031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2
RHEA:47928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + H2O + NADP(+) = (2S)-3-sulfolactate + 2 H(+) + NADPH
REACT:R-BTA-2730861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Bos taurus)
REACT:R-GGA-1306876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 activation by small molecules (Gallus gallus)
RHEA:45024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP(+)
RHEA:43037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine => 2-aminoprop-2-enoate + H(+) + hydrogen sulfide
REACT:R-SSC-6801687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Sus scrofa)
RHEA:19662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol 1-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH
GO:0008488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-glutamyl carboxylase activity
GO:0103093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthioalkylmalate dehydrogenase activity
GO:0018813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity
RHEA:29987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out)
RHEA:33962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + neomycin C <=> 6'''-deamino-6'''-oxoneomycin C + L-glutamate
RHEA:41403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:10928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + ATP + CoA = AMP + an acyl-CoA + diphosphate
REACT:R-DME-214853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WEK and MYD88:TUB bind to the TL receptor (Drosophila melanogaster)
REACT:R-GGA-9038161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Gallus gallus)
REACT:R-CFA-8854462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds VLDL (Canis familiaris)
REACT:R-CFA-196950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTRAP hydrolyzes FMN to RIB (Canis familiaris)
RHEA:32534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-glucose
REACT:R-SSC-977359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to membrane-associated Factor H:C3b (Sus scrofa)
RHEA:13374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-mimosine => 3-hydroxy-4H-pyrid-4-one + L-serine
REACT:R-GGA-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Gallus gallus)
RHEA:44818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-12 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+)
REACT:R-DRE-203625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)
REACT:R-MMU-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Mus musculus)
GO:0034017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-2,cis-3-decenoyl-ACP isomerase activity
GO:0034017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2, cis-3 decenoyl-ACP isomerase activity
GO:0034017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2-decenoyl-acyl-carrier-protein isomerase activity
GO:0034017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity
GO:0034017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-2-cis-3-decenoyl-ACP isomerase activity
GO:0034017	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-hydroxydecanoyl thioester dehydrase activity
GO:0034017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity
GO:0034017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-2-decenoyl-ACP isomerase activity
REACT:R-DRE-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)
REACT:R-CFA-417896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y6 receptor can bind to UDP (Canis familiaris)
GO:0008160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine phosphatase activator activity
REACT:R-CFA-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Canis familiaris)
RHEA:17638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene => hop-22(29)-ene
RHEA:57259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP <=> GTP + H(+) + lactate
REACT:R-CFA-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Canis familiaris)
REACT:R-HSA-3209098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA (Homo sapiens)
REACT:R-RNO-517536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Rattus norvegicus)
RHEA:19342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + octane + 2 reduced [rubredoxin] => H2O + octan-1-ol + 2 oxidized [rubredoxin]
RHEA:19458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrophenol + 2 H(+) + 2 NADPH + O2 => catechol + H2O + 2 NADP(+) + nitrite
RHEA:50692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate = ADP + alpha-maltose 1-phosphate + H(+)
RHEA:50692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-maltose-1-phosphate synthase"
RHEA:50692	skos:prefLabel	"alpha-maltose-1-phosphate synthase"
REACT:R-BTA-2028294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Bos taurus)
REACT:R-RNO-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Rattus norvegicus)
RHEA:21349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + 10 malonyl-CoA => 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2
RHEA:19092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-1 + S-adenosyl-L-homocysteine
REACT:R-GGA-2028735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind WWTR1 (TAZ) (Gallus gallus)
REACT:R-RNO-2396599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-5Y-LAT (Rattus norvegicus)
REACT:R-XTR-204773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb7 (Xenopus tropicalis)
REACT:R-HSA-5655313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 mutants bind PLCG1 (Homo sapiens)
GO:0016314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity
GO:0016314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MMAC1
GO:0016314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3)P 3-phosphatase activity
GO:0016314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity
GO:0016314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtdIns(3,4,5)P3 3-phosphatase activity
GO:0016314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 3-phosphatase activity
REACT:R-MMU-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Mus musculus)
REACT:R-CFA-9667563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR2 bind desmopressin (Canis familiaris)
REACT:R-DDI-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Dictyostelium discoideum)
REACT:R-DME-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Drosophila melanogaster)
REACT:R-HSA-193789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Homo sapiens)
RHEA:21860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate
RHEA:21860	skos:prefLabel	"quercetin-3,3'-bissulfate 7-sulfotransferase"
RHEA:21860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quercetin-3,3'-bissulfate 7-sulfotransferase"
RHEA:15997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)
REACT:R-PFA-8943987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCUBE1, SCUBE3 oligomerize (Plasmodium falciparum)
REACT:R-SSC-1433451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds to p-KIT (Sus scrofa)
REACT:R-DRE-444647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3a receptor binds anaphylatoxin C3a (Danio rerio)
RHEA:40259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA
GO:0080123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonyl-amino synthetase activity
GO:0080123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonate-amino synthetase activity
GO:0080123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ja-amino synthetase activity
GO:0080123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonate-amino acid conjugate synthetase activity
GO:0080123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonate-amino acid synthetase activity
GO:0080123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonate:amino acid synthetase activity
GO:0080123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonate-amido synthetase activity
GO:0080123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonic acid-amino synthetase activity
RHEA:68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isoscopoletin + S-adenosyl-L-homocysteine => esculetin + S-adenosyl-L-methionine
REACT:R-BTA-937044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 (Bos taurus)
REACT:R-HSA-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Homo sapiens)
RHEA:58178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopaoctaene + 2 diphosphate + NADP(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH
REACT:R-CFA-4086200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin matrix protein 1 binds integrin alphaVbeta3 (Canis familiaris)
REACT:R-DRE-8981657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds PTPRZ1 (Danio rerio)
REACT:R-DRE-5323526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRAT proteins bind GSK3beta (Danio rerio)
REACT:R-XTR-444661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR2 binds HCAR2 ligands (Xenopus tropicalis)
REACT:R-RNO-5690870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Rattus norvegicus)
RHEA:56408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-SSC-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Sus scrofa)
REACT:R-MMU-8874705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Mus musculus)
GO:0102360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daphnetin 3-O-glucosyltransferase activity
RHEA:22129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R,4S)-borneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH
REACT:R-MMU-3225851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin and activate MAP3K5 (Mus musculus)
RHEA:48398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine
REACT:R-HSA-212352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ARC coactivator complex (Homo sapiens)
RHEA:41430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => L-tyrosine + S-adenosyl-L-methionine
REACT:R-DRE-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Danio rerio)
REACT:R-MMU-194023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2,HSD11B1 dimer oxidise CORT to COR (Mus musculus)
RHEA:50006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11a-hydroxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + tetracycline
GO:0047509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dehydropantoate dehydrogenase activity
GO:0047509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aldopantoate dehydrogenase activity
GO:0047509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity
GO:0047509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity
GO:0008236	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serine protease activity
GO:0008236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-type peptidase activity
RHEA:30855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dammarenediol II synthase"
RHEA:30855	skos:prefLabel	"dammarenediol II synthase"
RHEA:30855	skos:altLabel	"dammarenediol synthase"
RHEA:30855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammarenediol-II = (S)-2,3-epoxysqualene + H2O
RHEA:30855	skos:altLabel	"2,3-oxidosqualene (20S)-dammarenediol cyclase"
REACT:R-CFA-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Canis familiaris)
RHEA:61662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl phosphate + ADP + H(+) => (2E)-geraniol + ATP
REACT:R-XTR-983707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates at the activated BCR (Xenopus tropicalis)
RHEA:72321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n chloride(out) + urate(in) => n chloride(in) + urate(out)
REACT:R-SSC-8875558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 binds CRK,CRKL (Sus scrofa)
RHEA:49016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C epoxide = 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one
RHEA:33857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a mannosylinositol-1-phosphophytoceramide + GDP + H(+) => an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose
RHEA:59398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-leucine => L-leucine
REACT:R-HSA-165034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rev multimer-bound  HIV mRNA:CRM1 complex associates with Ran:GTP (Homo sapiens)
RHEA:17781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-methionine = formate + L-methionine
RHEA:17781	skos:prefLabel	"formylmethionine deformylase"
RHEA:17781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formylmethionine deformylase"
GO:0016787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity
REACT:R-BTA-422017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase decanoylates Proghrelin (Bos taurus)
RHEA:45392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine
RHEA:40426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:64500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine = 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine
RHEA:35612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menadiol + 2 O2 => 2 H(+) + menadione + 2 superoxide
GO:0004945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin type II receptor activity
REACT:R-CFA-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Canis familiaris)
REACT:R-XTR-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Xenopus tropicalis)
REACT:R-RNO-5606996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds activated protein C (Rattus norvegicus)
REACT:R-DDI-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Dictyostelium discoideum)
GO:0016897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exoribonuclease activity, producing 3'-phosphomonoesters
GO:0016897	skos:prefLabel	"Exoribonucleases producing 3'-phosphomonoesters"
GO:0016897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Exoribonucleases producing 3'-phosphomonoesters"
RHEA:25958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)
RHEA:14553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C
RHEA:14553	skos:prefLabel	"cephalosporin-C transaminase"
RHEA:14553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cephalosporin-C transaminase"
RHEA:14553	skos:altLabel	"cephalosporin C aminotransferase"
REACT:R-MMU-5661517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC comlex binds OTULIN (Mus musculus)
RHEA:10144	skos:prefLabel	"3'-nucleotidase"
RHEA:10144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate
RHEA:10144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3'-nucleotidase"
REACT:R-HSA-5666008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCAI binds SRF:MKL1 (Homo sapiens)
REACT:R-HSA-5357928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)
REACT:R-BTA-114548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Bos taurus)
REACT:R-CFA-3296301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCRL2 binds CCL19 (Canis familiaris)
RHEA:72794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin-glucuronoside(out) <=> bilirubin-glucuronoside(in)
REACT:R-SSC-6786166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translesion synthesis across unhooked ICL by POLN (Sus scrofa)
REACT:R-DDI-9026006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Dictyostelium discoideum)
REACT:R-MMU-3295580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPM4,5 transport extracellular Na+ to cytosol (Mus musculus)
RHEA:69590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + uridine => inosine + UMP
RHEA:12850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-[myosin light chain] => L-seryl-[myosin light chain] + phosphate
RHEA:17314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidine + tRNA(His) => AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
REACT:R-XTR-5610722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI3 (Xenopus tropicalis)
REACT:R-RNO-9668902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18-RFC(7s) complex (Rattus norvegicus)
RHEA:24064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen
RHEA:24064	skos:altLabel	"aminolevulinate dehydratase"
RHEA:24064	skos:prefLabel	"porphobilinogen synthase"
RHEA:24064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"porphobilinogen synthase"
RHEA:24064	skos:altLabel	"delta-aminolevulinic acid dehydratase"
REACT:R-GGA-8987042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)
RHEA:36379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4alpha-methylzymosterol + H(+) + NADPH = 4alpha-methylzymosterol + NADP(+)
RHEA:63968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate + H(+) = atromentin + 2 H2O
RHEA:17768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate <=> (2R)-2,3-bisphosphoglycerate + H(+)
RHEA:16767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + H(+) + NADPH => D-mannitol + NADP(+)
REACT:R-RNO-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Rattus norvegicus)
RHEA:18226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[N-(6-aminohexanoyl)](n) + H2O => 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)
RHEA:59718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaonate + H(+) => D-maltopentaono-1,5-lactone + H2O
REACT:R-DME-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Drosophila melanogaster)
REACT:R-DRE-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Danio rerio)
RHEA:41602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine
RHEA:53643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-alpha-amorphene + diphosphate
RHEA:38597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O
RHEA:47973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O
RHEA:11351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite(in) + ATP + H2O <=> ADP + arsenite(out) + H(+) + phosphate
REACT:R-DME-190326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 (Drosophila melanogaster)
RHEA:43699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]
RHEA:54475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate
REACT:R-CFA-374207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled estrogen receptor 1 binds estrogen non-classically (Canis familiaris)
REACT:R-HSA-9024334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Homo sapiens)
REACT:R-HSA-3315455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CBLIF does not bind Cbl (Homo sapiens)
REACT:R-HSA-193665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYD88 dissociates (Homo sapiens)
GO:0010856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylate cyclase activator activity
RHEA:50592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH
REACT:R-GGA-6804596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1:CYCS binds APIP (Gallus gallus)
RHEA:37468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
REACT:R-MMU-2161187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Mus musculus)
REACT:R-DRE-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)
RHEA:53231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Mus musculus)
REACT:R-RNO-6793661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Rattus norvegicus)
RHEA:14907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine => 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate
GO:0008793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aromatic amino acid aminotransferase activity
GO:0008793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic aminotransferase activity
GO:0008793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic-amino-acid:2-oxoglutarate aminotransferase activity
GO:0008793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aromatic-amino-acid transaminase activity
GO:0008793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic amino acid transferase activity
GO:0008793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ArAT
RHEA:52486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A
REACT:R-BTA-1028821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Phospho IRF3 or phospho IRF7 (Bos taurus)
REACT:R-CFA-159762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)
GO:0051192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prosthetic group binding
REACT:R-RNO-6784676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)
REACT:R-GGA-174174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Gallus gallus)
RHEA:68844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate
RHEA:24266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + dihydroxyacetone => D-xylulose 5-phosphate + formaldehyde
REACT:R-CEL-201443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II receptor phosphorylates type I receptor (Caenorhabditis elegans)
REACT:R-RNO-5334854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAR:RXR binds SUMO-CRABP2:atRA (Rattus norvegicus)
RHEA:31981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + trimethylamine N-oxide => NADPH + O2 + trimethylamine
RHEA:48352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
REACT:R-HSA-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Homo sapiens)
REACT:R-HSA-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Homo sapiens)
REACT:R-SSC-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)
RHEA:62726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isomalbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)
RHEA:46083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetracosenoyl-CoA + H(+) + NADH <=> NAD(+) + tetracosanoyl-CoA
GO:0061579	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	autoinducer-1 synthase
GO:0061579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl homoserine lactone synthase activity
GO:0004553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-glucosyl hydrolase activity
RHEA:47424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-octadecadienoyl-CoA + H2O = (3S)-hydroxy-(9Z-octadecenoyl)-CoA
REACT:R-DRE-5225649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP7 binds histone H3 (Danio rerio)
GO:0015297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:solute antiporter activity
GO:0015297	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	porter
GO:0015297	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ion antiporter activity
GO:0015297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exchange transporter activity
GO:0015297	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	exchanger
GO:0015297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	antiporter activity
GO:0015297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	solute:solute exchange
GO:0015297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	countertransporter activity
GO:0015297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	antiport
REACT:R-MMU-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Mus musculus)
RHEA:53013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichlorohydroquinone + 2 glutathione => chloride + chlorohydroquinone + glutathione disulfide + H(+)
RHEA:14846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate 4-semialdehyde + pyruvate => (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O
GO:0106367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP
GO:0106367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor
RHEA:65605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + eicosanoyl-CoA => CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine
REACT:R-XTR-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Xenopus tropicalis)
RHEA:56458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-epi-fischerindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole
REACT:R-XTR-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Xenopus tropicalis)
REACT:R-CEL-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Caenorhabditis elegans)
REACT:R-SSC-202443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of CARMA1 (Sus scrofa)
RHEA:60386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(2,3-dihydroxybenzoyl)-L-serine trimer => enterobactin + H2O
REACT:R-CEL-9614564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO4 (Caenorhabditis elegans)
REACT:R-CEL-176669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Caenorhabditis elegans)
RHEA:52931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-GMP + 2 H2O <=> 2 GMP + 2 H(+)
REACT:R-SSC-8876484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 transfers CHOL to NPC1 (Sus scrofa)
RHEA:24993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-548830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA (Homo sapiens)
REACT:R-BTA-2032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ), TBX5, and PCAF form a complex (Bos taurus)
REACT:R-CFA-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Canis familiaris)
REACT:R-BTA-5323545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canonical WNT signaling through the atypical receptor RYK (Bos taurus)
REACT:R-DME-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Drosophila melanogaster)
REACT:R-SPO-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)
REACT:R-CFA-1236955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Movement of clathrin coated vesicles into early endosome (Canis familiaris)
REACT:R-RNO-266050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to LTC4 by LTC4S (Rattus norvegicus)
RHEA:48189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-SSC-392202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 12:Gi complex (Sus scrofa)
RHEA:13402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol => (2Z,6E)-farnesol
REACT:R-MMU-8987202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)
REACT:R-SSC-211206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of DFF to the nucleus (Sus scrofa)
RHEA:56930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:60147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-glutamyl-[protein] <=> ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate
REACT:R-BTA-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Bos taurus)
RHEA:26133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)
RHEA:28657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + H(+) + sulfite => glutathione S,S-dioxide + H2O
REACT:R-HSA-6787403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA (Homo sapiens)
REACT:R-MMU-8938356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RMB14 binds RUNX2 (Mus musculus)
RHEA:22011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine + succinyl-CoA <=> CoA + O-succinyl-L-homoserine
RHEA:27613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) <=> CO2 + H2
RHEA:63861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate
REACT:R-DDI-199202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphopantetheine conjugation of the ACP domain of FAS (Dictyostelium discoideum)
REACT:R-BTA-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)
REACT:R-DDI-5693356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEMIP hydrolyses HA (Dictyostelium discoideum)
REACT:R-DME-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Drosophila melanogaster)
RHEA:35920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose => H(+) + kanamycin D + UDP
GO:0102138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxatyphasterol synthase activity
RHEA:64514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine => (3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine
RHEA:10805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin => (R)-allantoin
REACT:R-HSA-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Homo sapiens)
RHEA:39149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA
RHEA:30098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + a menaquinone <=> a menaquinol + oxaloacetate
RHEA:48846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:23255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate
REACT:R-SPO-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Schizosaccharomyces pombe)
REACT:R-HSA-1855173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 transports from the nucleus to the cytosol (Homo sapiens)
REACT:R-MMU-917835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from holoTF:TFRC dimer (Mus musculus)
REACT:R-MMU-8862380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B13 binds lipid droplets (Mus musculus)
RHEA:40122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecanoyl-CoA <=> CoA + H(+) + tetradecanoate
RHEA:38398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)
RHEA:72013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(out) + urate(in) => glutathione(in) + urate(out)
GO:0070042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (uridine-N3-)-methyltransferase activity
RHEA:25098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UDP = ADP + UTP
RHEA:59290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + sphing-4-enine => beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O
RHEA:39018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-oxodocosanoate + H2O + NAD(+) <=> docosanedioate + 2 H(+) + NADH
REACT:R-HSA-2187358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters unphosphorylated SMAD2/3 (Homo sapiens)
REACT:R-HSA-9706287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to ABL2 (Homo sapiens)
RHEA:12122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + ATP + H(+)
REACT:R-GGA-165692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of 4E-BP1 by activated mTORC1 (Gallus gallus)
REACT:R-HSA-8956184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Homo sapiens)
REACT:R-HSA-9029580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Homo sapiens)
REACT:R-XTR-9727198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)
REACT:R-GGA-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Gallus gallus)
REACT:R-DDI-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)
REACT:R-DRE-8849068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARHGAP35 (Danio rerio)
RHEA:36023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-GGA-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Gallus gallus)
REACT:R-MMU-8943959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP9 cleave SCUBE3 (Mus musculus)
REACT:R-HSA-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Homo sapiens)
REACT:R-BTA-192335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Bos taurus)
REACT:R-CEL-2028644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Caenorhabditis elegans)
GO:0008873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-D-gluconate reductase activity
GO:0008873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ketogluconate reductase activity
GO:0008873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-gluconate:NADP+ oxidoreductase activity
GO:0008873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gluconate 2-dehydrogenase activity
RHEA:42043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose <=> gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)
RHEA:22581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxy-2-oxopentanoate => (2Z)-2-hydroxypenta-2,4-dienoate + H2O
REACT:R-SSC-5223313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Sus scrofa)
RHEA:28787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-threonine + ATP = 4-(phosphooxy)-L-threonine + ADP + H(+)
REACT:R-CFA-211951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1B1 4-hydroxylates EST17b (Canis familiaris)
RHEA:67881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + dopamine => adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)
RHEA:60148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate
RHEA:51106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CEL-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Caenorhabditis elegans)
RHEA:23152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+)
GO:0099604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-gated calcium channel activity
RHEA:70897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein] => N-terminal L-cysteinyl-[protein] + O2
RHEA:50345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH => 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)
REACT:R-GGA-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Gallus gallus)
RHEA:54938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + NAD(+) => (2E)-decenoyl-[ACP] + H(+) + NADH
RHEA:62410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine => 3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine
REACT:R-MMU-192434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of diacylglycerols by extracellular PTL:colipase (Mus musculus)
RHEA:18551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose
GO:0004569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endomannosidase activity
GO:0004569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoprotein endo-alpha-1,2-mannosidase activity
GO:0004569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoprotein glucosylmannohydrolase activity
GO:0004569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosylmannosidase activity
GO:0004569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-alpha-mannosidase activity
GO:0004569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosyl mannosidase activity
REACT:R-GGA-8864569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds TFAP2C (Gallus gallus)
REACT:R-SSC-446364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Migfilin interacts with VASP (Sus scrofa)
RHEA:27870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)
RHEA:27870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase"
RHEA:27870	skos:prefLabel	"2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase"
REACT:R-CFA-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Canis familiaris)
REACT:R-HSA-6785762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL13RA1 binds TYK2 (Homo sapiens)
REACT:R-HSA-139855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X1-mediated entry of Ca++ from plasma (Homo sapiens)
REACT:R-BTA-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)
REACT:R-DRE-5610758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Danio rerio)
REACT:R-SSC-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Sus scrofa)
REACT:R-DRE-2066781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Danio rerio)
RHEA:58210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + alstonine => A + dihydroalstonine
RHEA:22228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + presqualene diphosphate = diphosphate + NAD(+) + squalene
RHEA:42171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH
GO:0004856	skos:altLabel	"Xylulose kinase"
GO:0004856	skos:prefLabel	"xylulokinase"
GO:0004856	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-xylulose 5-phosphotransferase activity
GO:0004856	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylulokinase activity
GO:0004856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)
GO:0004856	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylulokinase (phosphorylating)
GO:0004856	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylulose kinase activity
GO:0004856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylulokinase"
GO:0004856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulokinase activity
RHEA:38776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
GO:0018136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-thiazoline dehydrogenase activity
GO:0046790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	virion binding
RHEA:49867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)
REACT:R-DME-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Drosophila melanogaster)
REACT:R-CEL-70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Caenorhabditis elegans)
REACT:R-BTA-2161999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Bos taurus)
RHEA:13203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + L-ornithine => glycine + L-arginine
REACT:R-CFA-9011595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Canis familiaris)
REACT:R-MMU-5607736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 oligomerizes (Mus musculus)
REACT:R-MMU-4719436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO1 (Mus musculus)
RHEA:68307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] <=> 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)
RHEA:43980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + NADPH + O2 = 15-hydroxyhexadecanoate + H2O + NADP(+)
REACT:R-HSA-9684016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)
REACT:R-HSA-1297444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of cAMP to HCN channels (Homo sapiens)
REACT:R-DRE-352103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Danio rerio)
REACT:R-HSA-5674130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
REACT:R-RNO-5649726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Rattus norvegicus)
REACT:R-BTA-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Bos taurus)
REACT:R-RNO-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Rattus norvegicus)
RHEA:48347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + UDP-alpha-D-galactose <=> a D-galactosylceramide + H(+) + UDP
RHEA:34927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + selenodiglutathione = glutathione + glutathioselenol + NADP(+)
RHEA:66697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine
RHEA:54471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate
RHEA:18506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)
REACT:R-DDI-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)
REACT:R-BTA-4088134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates FOXM1 (Bos taurus)
RHEA:31402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diapophytofluene + FAD + H(+) <=> all-trans-4,4'-diapo-zeta-carotene + FADH2
REACT:R-SCE-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Saccharomyces cerevisiae)
RHEA:71449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(out) + Na(+)(out) => D-alanine(in) + Na(+)(in)
RHEA:32405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2S,4R)-neodihydrocarveol + NAD(+)
RHEA:44583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) <=> 2-all-trans-decaprenylphenol + CO2
GO:0016672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor
GO:0016672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
GO:0016672	skos:prefLabel	"With a quinone or similar compound as acceptor"
GO:0016672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor
REACT:R-HSA-9730736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA (Homo sapiens)
REACT:R-DRE-9632906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ recruits RAS in response to estrogen stimulation (Danio rerio)
REACT:R-GGA-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Gallus gallus)
REACT:R-SSC-8874979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD3 binds GOLGB1 (Sus scrofa)
REACT:R-GGA-110251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of hypoxanthine by MPG glycosylase (Gallus gallus)
RHEA:48192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:47585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GT1c (d18:1(4E)) + H(+) + UDP
REACT:R-BTA-432096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated integrin alphaIIb beta3 binds SHC1 (Bos taurus)
GO:0102280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline monooxygenase activity (NADP-dependent)
REACT:R-RNO-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Rattus norvegicus)
REACT:R-HSA-1791057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TSPYL2 (Homo sapiens)
GO:0047422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-D-aspartate amidohydrolase activity
GO:0047422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl-D-aspartate deacylase activity
RHEA:69915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(out) + 2 Na(+)(out) = guanosine(in) + 2 Na(+)(in)
REACT:R-CFA-193052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione isomerizes to progesterone (Canis familiaris)
REACT:R-XTR-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Xenopus tropicalis)
REACT:R-CEL-71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Caenorhabditis elegans)
RHEA:20873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + UDP-alpha-D-glucose => (20S)-ginsenoside Rb1 + H(+) + UDP
REACT:R-CFA-176250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR-ATRIP to the RPA-ssDNA complex (Canis familiaris)
REACT:R-HSA-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Homo sapiens)
REACT:R-CFA-9012036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)
REACT:R-CFA-2160492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4I1:FAD oxidises L-Phe to kPPV (Canis familiaris)
REACT:R-RNO-6805650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)
RHEA:15358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose => demethyllactenocin + dTDP + H(+)
GO:0047630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphate phosphoglycerate phosphatase activity
GO:0047630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADPphosphoglycerate phosphatase activity
GO:0047630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-phosphoglycerate phosphatase activity
GO:0047630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(ADP)-2-phosphoglycerate phosphohydrolase activity
RHEA:31376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pyrrole-2-carboxylate => 1H-pyrrole + CO2
GO:0016794	skos:prefLabel	"Diphosphoric monoester hydrolases"
GO:0016794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Diphosphoric monoester hydrolases"
GO:0016794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphoric monoester hydrolase activity
REACT:R-DRE-5654222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PLCG1 (Danio rerio)
RHEA:15901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate
REACT:R-DRE-450474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates BRF1 (Danio rerio)
RHEA:42886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP
RHEA:42052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH
REACT:R-DME-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Drosophila melanogaster)
RHEA:18659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + H(+) + NADPH => (R)-glycerate + NADP(+)
REACT:R-HSA-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Homo sapiens)
REACT:R-HSA-6785898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R binds JAK2 (Homo sapiens)
REACT:R-GGA-9009910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds p-S423,S425-SMAD3 (Gallus gallus)
REACT:R-XTR-190385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3b (Xenopus tropicalis)
RHEA:26248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate <=> diphosphate + fusicocca-2,10(14)-diene
REACT:R-GGA-5218851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Gallus gallus)
GO:0102649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-ACP synthase activity
GO:0050513	skos:altLabel	"beta1,2-xylosyltransferase"
GO:0050513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
GO:0050513	skos:prefLabel	"glycoprotein 2-beta-D-xylosyltransferase"
GO:0050513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycoprotein 2-beta-D-xylosyltransferase"
GO:0050513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,2-xylosyltransferase activity
GO:0050513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoprotein 2-beta-D-xylosyltransferase activity
GO:0050513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-beta-xylosyltransferase activity
GO:0050513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoprotein 2-b-D-xylosyltransferase activity
REACT:R-SSC-3301943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTK1 dimer transfers GS from GSH to CDNB (Sus scrofa)
REACT:R-CEL-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)
RHEA:58132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine
RHEA:70883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) = H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)
REACT:R-HSA-8869590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The APOE gene transcription is stimulated by the complex of TFAP2A homodimer and DEK (Homo sapiens)
RHEA:63620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dodecanoate + holo-[ACP] = AMP + diphosphate + dodecanoyl-[ACP]
REACT:R-DRE-5362553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTUM releases Hh-Np:GPC5 from the plasma membrane (Danio rerio)
RHEA:36537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-docosanoylsphinganine => docosanoyl-CoA + sphinganine
RHEA:52683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-alpha-phenylglycine <=> CoA + H(+) + N-acetyl-L-alpha-phenylglycine
RHEA:18545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-L-pentonate aldolase"
RHEA:18545	skos:altLabel	"2-keto-3-deoxy-L-pentonate aldolase"
RHEA:18545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-arabinonate = glycolaldehyde + pyruvate
RHEA:18545	skos:prefLabel	"2-dehydro-3-deoxy-L-pentonate aldolase"
RHEA:18545	skos:altLabel	"2-keto-3-deoxy-L-arabonate aldolase"
RHEA:18545	skos:altLabel	"2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase"
REACT:R-CEL-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)
RHEA:14113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + phosphate
RHEA:14113	skos:prefLabel	"polynucleotide 3'-phosphatase"
RHEA:14113	skos:altLabel	"2'(3')-polynucleotidase"
RHEA:14113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polynucleotide 3'-phosphatase"
RHEA:62809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-3343700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)
RHEA:37606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
RHEA:29500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-alpha-barbatene + diphosphate
GO:0004016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl cyclase activity
GO:0004016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylylcyclase activity
GO:0004016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylate cyclase activity
GO:0004016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity
GO:0004016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP diphosphate-lyase (cyclizing) activity
GO:0004016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cAMP generating peptide activity
GO:0004016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3',5'-cyclic AMP synthetase activity
GO:0004016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenyl cyclase activity
GO:0004016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP pyrophosphate-lyase activity
REACT:R-XTR-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Xenopus tropicalis)
RHEA:18155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GTP + H(+)
RHEA:59060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + H2O = (20S)-ginsenoside Rh2 + D-glucose
RHEA:64136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-asparagine = (9Z)-octadecenoate + L-asparagine
REACT:R-GGA-380076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 1 (NK1) binds to substance P (Gallus gallus)
REACT:R-MMU-8954468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Mus musculus)
REACT:R-RNO-9038163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Rattus norvegicus)
RHEA:24309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:68831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	borneol + NAD(+) <=> camphor + H(+) + NADH
REACT:R-GGA-1247497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds neuregulins (Gallus gallus)
REACT:R-CEL-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Caenorhabditis elegans)
REACT:R-MMU-5138441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A-FZD4 recruits DVL2 (Mus musculus)
RHEA:16051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)alamin + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole
GO:0061785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan endopeptidase activity
REACT:R-HSA-2299725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol (Homo sapiens)
REACT:R-HSA-5693373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Homo sapiens)
GO:0047427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanoalanine nitrilase activity
GO:0047427	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyanoalanine nitrilase activity
GO:0047427	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-cyano-L-alanine aminohydrolase activity
REACT:R-XTR-170672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Xenopus tropicalis)
RHEA:32117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + succinate + TRIBOA beta-D-glucoside => 2-oxoglutarate + DIBOA beta-D-glucoside + O2
REACT:R-SSC-9691621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5 binds C5 inhibitors (Sus scrofa)
REACT:R-GGA-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Gallus gallus)
RHEA:17773	skos:altLabel	"cysteinyl-tRNA synthetase"
RHEA:17773	skos:prefLabel	"cysteine--tRNA ligase"
RHEA:17773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine--tRNA ligase"
RHEA:17773	skos:altLabel	"cysteine translase"
RHEA:17773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)
REACT:R-BTA-391155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRPA binds SFTPA oligomer, SFTPD oligomer (Bos taurus)
RHEA:38909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-laudanine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine
REACT:R-HSA-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)
REACT:R-XTR-2176491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L binds phosphorylated linker region of SMAD2/3 (Xenopus tropicalis)
REACT:R-XTR-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Xenopus tropicalis)
RHEA:17481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH
REACT:R-HSA-6801089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates RABGGTA expression (Homo sapiens)
REACT:R-GGA-1250280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin (Gallus gallus)
REACT:R-CEL-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
REACT:R-MMU-6788392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Mus musculus)
REACT:R-BTA-5675373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)
REACT:R-MMU-9701524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated downstream of active ALK (Mus musculus)
EC:2.7.1.162	skos:prefLabel	"N-acetylhexosamine 1-kinase"
EC:2.7.1.162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylhexosamine 1-kinase"
EC:2.7.1.162	skos:altLabel	"N-acetylgalactosamine/N-acetylglucosamine 1-kinase"
REACT:R-SSC-74740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SHC1 to insulin receptor (Sus scrofa)
RHEA:55685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + NH4(+) => 4-amino-4-deoxychorismate + H2O
REACT:R-CFA-9674529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds to TBXA2R (Canis familiaris)
REACT:R-HSA-443910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
RHEA:34207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-O-alpha-D-glucosyl-L-rhamnose phosphorylase"
RHEA:34207	skos:prefLabel	"3-O-alpha-D-glucosyl-L-rhamnose phosphorylase"
RHEA:34207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-alpha-D-glucosyl-L-rhamnose + phosphate = beta-D-glucose 1-phosphate + L-rhamnopyranose
RHEA:56193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP
GO:0080015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sabinene synthase activity
REACT:R-HSA-199518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3d-complexed antigen binds to complement receptor (Homo sapiens)
RHEA:70289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 3,4,6-trisphosphate + ATP
REACT:R-SSC-183084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Sus scrofa)
REACT:R-CEL-1013013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of GABA B receptor with G protein beta-gamma subunits (Caenorhabditis elegans)
RHEA:33461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + zymosterol => H(+) + NADPH + zymosterone
REACT:R-DRE-176609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + PAPS => cholesterol sulfate + PAP (Danio rerio)
RHEA:43789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O => ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate
RHEA:12274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dopamine => H(+) + L-dopa
REACT:R-HSA-9619666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-PRX:DRP2 binds dystroglycan and laminin-211 (Homo sapiens)
RHEA:55448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:55448	skos:altLabel	"F3',5'H"
RHEA:55448	skos:altLabel	"F3'5'H"
RHEA:55448	skos:prefLabel	"flavonoid 3',5'-hydroxylase"
RHEA:55448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonoid 3',5'-hydroxylase"
REACT:R-CFA-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Canis familiaris)
REACT:R-SSC-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Sus scrofa)
REACT:R-GGA-5668605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2:GTP binds NOX2 complex (Gallus gallus)
RHEA:71327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-threonine(out) + 2 Na(+)(out) = chloride(in) + L-threonine(in) + 2 Na(+)(in)
REACT:R-XTR-9731931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds selective ERAs (Xenopus tropicalis)
REACT:R-BTA-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Bos taurus)
GO:0102086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-vanillate-L-glutamate synthetase activity
REACT:R-GGA-8875817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates STAT3 (Gallus gallus)
REACT:R-HSA-9756603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 S binds SFTPD 12mer (Homo sapiens)
REACT:R-CFA-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
REACT:R-GGA-8851888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds SHC1-2 (Gallus gallus)
REACT:R-BTA-443910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 dissociates from integrin alphaIIb beta3 (Bos taurus)
RHEA:70917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(out) + H(+)(out) => guanosine(in) + H(+)(in)
GO:0070529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan aminotransferase activity
REACT:R-GGA-8854052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the SCF-FBXL7 complex (Gallus gallus)
REACT:R-HSA-448627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-35 translocates from the ER lumen to the extracellular region (Homo sapiens)
RHEA:33556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + H2O => (4R)-hydroxysphinganine + a fatty acid
RHEA:55185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylundecanoyl-CoA + O2 => 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate
REACT:R-CFA-6814549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA transcript initiation, Integrator binding, LEC binding (Canis familiaris)
RHEA:34653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine
RHEA:46033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + tetradecanoate => (2S)-hydroxytetradecanoate + H2O
REACT:R-HSA-9621411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2 and SREBF2(1-484) dimer bind HMGCR gene (Homo sapiens)
REACT:R-RNO-5687112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 is degraded by the 26S proteasome (Rattus norvegicus)
RHEA:67234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+)
RHEA:50791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pentan-2-one <=> (E)-pent-3-en-2-one + H(+) + NADPH
REACT:R-SSC-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Sus scrofa)
REACT:R-MMU-5693012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF15 binds TNFRSF25 (Mus musculus)
RHEA:12521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa => (E)-caffeate + NH4(+)
REACT:R-SSC-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Sus scrofa)
GO:0050348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose O-mycolyltransferase activity
GO:0050348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity
GO:0050348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity
REACT:R-RNO-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Rattus norvegicus)
REACT:R-RNO-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Rattus norvegicus)
REACT:R-RNO-193789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Rattus norvegicus)
REACT:R-BTA-9759209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2 binds extracellular TCN2:RCbl (Bos taurus)
RHEA:36557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-eicosanoylsphinganine => eicosanoyl-CoA + sphinganine
GO:0047301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity
GO:0047301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine-3-methyl-2-oxovalerate aminotransferase activity
GO:0047301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine-3-methyl-2-oxovalerate transaminase activity
GO:0047301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine-2-keto-methylvalerate aminotransferase activity
GO:0047301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine--3-methyl-2-oxovalerate aminotransferase activity
GO:0047301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine--isoleucine transaminase activity
GO:0047301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine--isoleucine aminotransferase activity
RHEA:60375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose(out) <=> D-fructose(in)
GO:0047908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fusarinine-C ornithinesterase activity
GO:0047908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-N-acyl-L-ornithine-ester hydrolase activity
GO:0047908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-acyl-L-ornithine-ester hydrolase activity
GO:0047908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine esterase activity
REACT:R-HSA-9014320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARM binds viral dsRNA:TLR3:TICAM1 (Homo sapiens)
REACT:R-HSA-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Homo sapiens)
RHEA:11855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + S-methyl-5'-thioadenosine <=> adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
REACT:R-BTA-5649734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates NEIL1,NEIL2-generated single strand break (Bos taurus)
RHEA:48451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine
REACT:R-HSA-390912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds hist (Homo sapiens)
RHEA:47737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:32764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-methyl-D-ornithine + ATP + L-lysine => (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate
GO:0008199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric iron binding
REACT:R-MMU-3465429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(S) and procaspase-8 form heterodimer (Mus musculus)
REACT:R-BTA-373745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK1 homophillic interaction (Bos taurus)
RHEA:68667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
RHEA:10659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosyl-L-methionine <=> creatine + H(+) + S-adenosyl-L-homocysteine
RHEA:58454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine
RHEA:34310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol + NADPH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite
RHEA:64885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP => (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)
REACT:R-HSA-8939670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2:CBFB binds the ITGA5 gene promoter (Homo sapiens)
REACT:R-RNO-374922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenalin synaptic vesicle docking and priming (Rattus norvegicus)
REACT:R-HSA-193482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(R) DHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)
REACT:R-MMU-6799977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 hydrolyzes bacterial peptidoglycan (Mus musculus)
RHEA:65328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chrodrimanin F = AH2 + chrodrimanin H
REACT:R-SSC-392195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi activation by P2Y purinoceptor 12 (Sus scrofa)
RHEA:50892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+) + hydrogen sulfide + sulfite = a menaquinol + thiosulfate
RHEA:30891	skos:altLabel	"cysteine synthase B"
RHEA:30891	skos:prefLabel	"S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)"
RHEA:30891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)"
RHEA:30891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + thiosulfate = acetate + H(+) + S-sulfo-L-cysteine
RHEA:32435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocarvone + H(+) + NADPH + O2 = 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
REACT:R-BTA-451895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RG binds JAK3 (Bos taurus)
RHEA:22131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R,4S)-borneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH
REACT:R-RNO-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Rattus norvegicus)
REACT:R-BTA-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Bos taurus)
RHEA:52198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:19083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a halide anion + a primary alcohol + H(+) => 1-haloalkane + H2O
RHEA:11262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NADP(+) => H(+) + NADPH + O2
REACT:R-RNO-264871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin B1 (Rattus norvegicus)
REACT:R-HSA-8856808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of AP-2 complex and clathrin (Homo sapiens)
REACT:R-CFA-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Canis familiaris)
REACT:R-GGA-9013024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors at the plasma membrane (Gallus gallus)
RHEA:20115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 6-phosphate => beta-D-glucose 1-phosphate
RHEA:20717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + S-adenosyl-L-homocysteine => NH4(+) + S-inosyl-L-homocysteine
REACT:R-XTR-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Xenopus tropicalis)
REACT:R-DRE-389381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gads binds CD28 (Danio rerio)
RHEA:70807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-sulfo-D-erythrose = 4-deoxy-4-sulfo-D-erythrulose
REACT:R-SCE-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Saccharomyces cerevisiae)
EC:3.4.21.46	skos:altLabel	"C3 convertase activator"
EC:3.4.21.46	skos:prefLabel	"complement factor D"
EC:3.4.21.46	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"complement factor D"
EC:3.4.21.46	skos:altLabel	"C3 proactivator convertase"
REACT:R-DRE-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Danio rerio)
REACT:R-MMU-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Mus musculus)
GO:0047255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity
GO:0047255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity
GO:0047255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactogen 6beta-galactosyltransferase activity
GO:0047255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-(1,6)-D-galactosyltransferase activity
GO:0047255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactogen 6-beta-galactosyltransferase activity
GO:0047255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,6-D-galactosyltransferase activity
GO:0047255	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-galactogen galactosyltransferase activity
REACT:R-RNO-5654582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates SHC1 (Rattus norvegicus)
RHEA:16166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 => CO2 + H2O + indole-3-acetamide
REACT:R-RNO-1462039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-HNP1-4 are cleaved to biologically active defensin (Rattus norvegicus)
RHEA:15040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + S-adenosyl-L-methionine <=> H(+) + N-methylputrescine + S-adenosyl-L-homocysteine
GO:0031818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 nucleotide receptor binding
GO:0031818	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P2Y9 nucleotide receptor ligand
REACT:R-GGA-77608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of A1CF to stem-looped RNA (Gallus gallus)
REACT:R-XTR-2562526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates OPTN (Xenopus tropicalis)
RHEA:39854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + glycerol
RHEA:41018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA
REACT:R-PFA-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Plasmodium falciparum)
RHEA:14502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-homocysteine => 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)
GO:0060589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPase regulator activity
GO:0060589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-triphosphatase regulator activity
RHEA:13501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biotin carboxylase"
RHEA:13501	skos:prefLabel	"biotin carboxylase"
RHEA:13501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate
RHEA:32768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-2465938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates atROL taken up by Muller cells (Homo sapiens)
REACT:R-DME-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)
RHEA:69703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O = beta-D-galactose + N-hexadecanoylsphing-4-enine
REACT:R-HSA-9749609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCHE hydrolyzes ASA- (Homo sapiens)
REACT:R-GGA-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Gallus gallus)
RHEA:38868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(516) in 16S rRNA => pseudouridine(516) in 16S rRNA
REACT:R-HSA-9622627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL6 gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)
REACT:R-SSC-5682858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate H2AFX (Sus scrofa)
RHEA:69265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkanimidothioate => an isothiocyanate + sulfate
RHEA:61484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine
GO:0034530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxymethylsalicyaldehyde dehydrogenase activity
RHEA:47463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(5Z-tetradecenoyl)-CoA + CoA <=> (3Z)-dodecenoyl-CoA + acetyl-CoA
RHEA:41696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate
REACT:R-GGA-1433456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs (Gallus gallus)
GO:0045028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purinergic nucleotide receptor activity, G-protein coupled
GO:0045028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P2Y
GO:0045028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P2Y receptor
GO:0045028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled purinergic nucleotide receptor activity
GO:0045028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled purinergic nucleotide receptor activity
GO:0045028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled purinergic nucleotide receptor activity
GO:0045028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purinergic nucleotide receptor activity, G protein coupled
REACT:R-DME-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-DDI-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Dictyostelium discoideum)
REACT:R-SCE-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Saccharomyces cerevisiae)
RHEA:71429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)
REACT:R-DRE-5654667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)
REACT:R-BTA-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Bos taurus)
REACT:R-DDI-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Dictyostelium discoideum)
REACT:R-DME-209107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further phosphorylation of APC by DCO (Drosophila melanogaster)
RHEA:31629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethymycin + dTDP + H(+) => 10-deoxymethynolide + dTDP-alpha-D-desosamine
GO:0102576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-palmitoyl-ACP hydrolase activity
REACT:R-HSA-5689544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds INO80 complex (Homo sapiens)
REACT:R-XTR-174551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of alternative pathway C5 convertase (Xenopus tropicalis)
REACT:R-HSA-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Homo sapiens)
REACT:R-HSA-3000103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN:AMN binds CBLIF:RCbl (Homo sapiens)
REACT:R-XTR-193965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 18HCORST to ALDO (Xenopus tropicalis)
RHEA:32352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 S-adenosyl-L-methionine + tricetin => 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine
RHEA:50922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2
RHEA:42253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + pentanoyl-CoA => 3-oxoheptanoyl-[ACP] + CO2 + CoA
RHEA:52987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]
REACT:R-MMU-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)
REACT:R-PFA-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Plasmodium falciparum)
REACT:R-DRE-9668395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CC2D1B (Danio rerio)
RHEA:37810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:15955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + 2 H(+) + N(4)-phosphoagmatine => agmatine + ATP
RHEA:23319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + 2-oxoglutarate + O2 <=> 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil
REACT:R-PFA-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Plasmodium falciparum)
REACT:R-SSC-444838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 1 binds relaxin 2 and 3 (Sus scrofa)
REACT:R-HSA-437129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT7 transports zinc into the golgi apparatus (Homo sapiens)
RHEA:14089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + glycine = glyoxylate + L-glutamate
RHEA:14089	skos:prefLabel	"glycine transaminase"
RHEA:14089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine transaminase"
RHEA:14089	skos:altLabel	"glycine aminotransferase"
REACT:R-HSA-9691621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5 binds C5 inhibitors (Homo sapiens)
GO:0033980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphonopyruvate decarboxylase activity
GO:0033980	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity
GO:0033980	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphonopyruvate carboxy-lyase activity
REACT:R-CFA-193065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Canis familiaris)
REACT:R-DRE-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Danio rerio)
REACT:R-XTR-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)
RHEA:25782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine
RHEA:47809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0106251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4-acetylcytidine amidohydrolase activity
GO:0106251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-acetylcytidine = acetate + cytidine + H(+)
REACT:R-XTR-216064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha8beta1 with Tenascin-C (Xenopus tropicalis)
REACT:R-CFA-9686930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is cleaved by CASP8 (Canis familiaris)
REACT:R-GGA-9708104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE5A dimer binds PDE5A inhibitors (Gallus gallus)
RHEA:18199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexyl isocyanide + H2O => H(+) + N-cyclohexylformamide
RHEA:18598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [rubredoxin] => NADH + 2 oxidized [rubredoxin]
RHEA:54621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + eicosanoyl-CoA + O2 => 2-hydroxyeicosanoyl-CoA + CO2 + succinate
REACT:R-XTR-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Xenopus tropicalis)
RHEA:57606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:20749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + penicillin N => CO2 + deacetoxycephalosporin C + H2O + succinate
REACT:R-SSC-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Sus scrofa)
RHEA:64487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA <=> 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA
REACT:R-CFA-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
RHEA:28312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose
REACT:R-RNO-2468287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)
GO:0047067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen:quinone oxidoreductase activity
GO:0047067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:menaquinone oxidoreductase activity
GO:0047067	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	membrane-bound hydrogenase activity
GO:0047067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinone-reactive Ni/Fe-hydrogenase activity
GO:0047067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen-ubiquinone oxidoreductase activity
RHEA:58846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-hydroxygeranial + NAD(+)
RHEA:24198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NAD(+)
REACT:R-DRE-5668984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 or PAK2 phosphorylates MYLK (Danio rerio)
RHEA:46547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:71669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(in) + succinate(out) => malonate(out) + succinate(in)
RHEA:69819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hypotaurine + NADPH + O2 = H2O + NADP(+) + taurine
REACT:R-HSA-9025999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Homo sapiens)
GO:0016836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydro-lyase activity
REACT:R-BTA-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Bos taurus)
REACT:R-HSA-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Homo sapiens)
RHEA:58517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)
RHEA:26396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 O2 <=> 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
RHEA:58058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfinoacetaldehyde + L-alanine => hypotaurine + pyruvate
RHEA:66954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+) => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose
REACT:R-GGA-9733292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind pramlintide (Gallus gallus)
REACT:R-DRE-421426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ProGIP translocates from the ER Lumen to secretory granules (Danio rerio)
REACT:R-SSC-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Sus scrofa)
RHEA:56425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:34372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+)
REACT:R-SSC-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Sus scrofa)
RHEA:36850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + L-threonyl-[protein] <=> AMP + FMN-L-threonyl-[protein] + H(+)
REACT:R-HSA-174660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Homo sapiens)
REACT:R-CFA-5682967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 binds DNA DSBs (Canis familiaris)
REACT:R-DME-389632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)
REACT:R-XTR-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Xenopus tropicalis)
RHEA:72986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + harmol <=> 6-(3-dimethylallyl)harmol + diphosphate
REACT:R-HSA-917693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESCRT Disassembly (Homo sapiens)
RHEA:56755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Mus musculus)
GO:0098848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming)
GO:0098848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity
REACT:R-MTU-936745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylation of O-acetylserine and sulfhydrylation using CysK2 (Mycobacterium tuberculosis)
GO:0071972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan L,D-transpeptidase activity
RHEA:72092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + Na(+)(out) => (R)-carnitine(in) + Na(+)(in)
REACT:R-MMU-157849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)
RHEA:35073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol(out) => 4-methylphenol(in)
REACT:R-SSC-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Sus scrofa)
RHEA:66818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tetrahydroxoborate(out) => 2 Na(+)(in) + tetrahydroxoborate(in)
RHEA:35191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"noranthrone monooxygenase"
RHEA:35191	skos:prefLabel	"noranthrone monooxygenase"
RHEA:35191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	noranthrone + O2 = H2O + norsolorinic acid
RHEA:35191	skos:altLabel	"norsolorinate anthrone oxidase"
REACT:R-DRE-2993780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO1 from E1 to UBE2I (UBC9) (Danio rerio)
REACT:R-HSA-2022860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Homo sapiens)
GO:0046848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylapatite binding
GO:0046848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyapatite binding
REACT:R-HSA-5228411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-mediated endocytosis of tetX HC:LC:gangliosides (Homo sapiens)
REACT:R-DRE-933531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-IRF7:p-IRF7 to nucleus (Danio rerio)
REACT:R-DME-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Drosophila melanogaster)
REACT:R-GGA-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Gallus gallus)
RHEA:60002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + 2 H(+) + phosphate => hydroxymethylphosphonate + O2
REACT:R-SSC-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Sus scrofa)
RHEA:48624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate
REACT:R-DRE-2090043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(7) (Danio rerio)
EC:3.2.1.18	skos:prefLabel	"exo-alpha-sialidase"
EC:3.2.1.18	skos:altLabel	"neuraminidase"
EC:3.2.1.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exo-alpha-sialidase"
EC:3.2.1.18	skos:altLabel	"alpha-neuraminidase"
EC:3.2.1.18	skos:altLabel	"N-acylneuraminate glycohydrolase"
EC:3.2.1.18	skos:altLabel	"sialidase"
RHEA:30102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate
REACT:R-RNO-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Rattus norvegicus)
RHEA:31498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP
RHEA:70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octanoyl-3-oxosphinganine => 3-oxosphinganine + octanoyl-CoA
RHEA:69720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + ATP + H(+) => (indol-3-yl)acetyl-AMP + diphosphate
REACT:R-RNO-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Rattus norvegicus)
REACT:R-SCE-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Saccharomyces cerevisiae)
RHEA:39615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA = (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O
RHEA:34309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrocatechol + NADPH + O2
REACT:R-HSA-3322135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MMAA does not protect MUT (Homo sapiens)
EC:3.4.23.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"penicillopepsin"
EC:3.4.23.20	skos:altLabel	"peptidase A"
EC:3.4.23.20	skos:altLabel	"Penicillium janthinellum aspartic protease"
EC:3.4.23.20	skos:prefLabel	"penicillopepsin"
RHEA:18585	skos:altLabel	"triosephosphate mutase"
RHEA:18585	skos:altLabel	"phosphotriose isomerase"
RHEA:18585	skos:altLabel	"triosephosphate isomerase"
RHEA:18585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
RHEA:18585	skos:prefLabel	"triose-phosphate isomerase"
RHEA:18585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"triose-phosphate isomerase"
RHEA:18585	skos:altLabel	"triose phosphoisomerase"
REACT:R-HSA-1222704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KatG reduces H2O2 (Homo sapiens)
RHEA:17197	skos:prefLabel	"4-hydroxyphenylpyruvate oxidase"
RHEA:17197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylpyruvate oxidase"
RHEA:17197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2
RHEA:43744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)
RHEA:43744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Ile)-lysidine synthetase"
RHEA:43744	skos:prefLabel	"tRNA(Ile)-lysidine synthetase"
RHEA:43744	skos:altLabel	"isoleucine-specific transfer ribonucleate lysidine synthetase"
REACT:R-CFA-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Canis familiaris)
REACT:R-SSC-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Sus scrofa)
REACT:R-HSA-8852200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of LCK by PTPN22 (Homo sapiens)
REACT:R-HSA-9756134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Homo sapiens)
REACT:R-BTA-6814734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDSN binds the cornified envelope (Bos taurus)
RHEA:47373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + D-glucose => a quinol + D-glucono-1,5-lactone
REACT:R-RNO-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Rattus norvegicus)
RHEA:20256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,3-dimethylmalate <=> dimethylmaleate + H2O
GO:0047593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-acetylglucose deacetylase activity
GO:0047593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-O-acetylglucose deacetylase activity
GO:0047593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-acetyl-D-glucose acetylhydrolase activity
RHEA:31570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisphenol A + H(+) + NADH + O2 <=> 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)
GO:0047434	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-pyruvate decarboxylase activity
GO:0047434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indolepyruvate decarboxylase activity
GO:0047434	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indol-3-yl-pyruvate carboxy-lyase activity
GO:0047434	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]
GO:0047434	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(indol-3-yl)pyruvate carboxy-lyase activity
REACT:R-SSC-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Sus scrofa)
REACT:R-DRE-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Danio rerio)
RHEA:64798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+) => H2O + L-lysine + NADP(+)
REACT:R-MTU-879322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycothione is reduced to mycothiol (Mycobacterium tuberculosis)
REACT:R-MMU-6814165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates CSA to HTAU (Mus musculus)
RHEA:36131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine
RHEA:36131	skos:prefLabel	"indole-3-acetate O-methyltransferase"
RHEA:36131	skos:altLabel	"IAA carboxylmethyltransferase"
RHEA:36131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-acetate O-methyltransferase"
REACT:R-DRE-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Danio rerio)
REACT:R-HSA-8961915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC45 gene expression is stimulated by E2F1 (Homo sapiens)
REACT:R-RNO-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Rattus norvegicus)
REACT:R-DME-69600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
REACT:R-MMU-419646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:Met (Mus musculus)
REACT:R-RNO-77584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Rattus norvegicus)
REACT:R-GGA-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Gallus gallus)
RHEA:48694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O
RHEA:70318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine
RHEA:20330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[low-density-lipoprotein receptor] => ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]
REACT:R-CEL-450222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)
RHEA:62653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1
RHEA:21380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phytanate--CoA ligase"
RHEA:21380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA
RHEA:21380	skos:prefLabel	"phytanate--CoA ligase"
RHEA:46242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:14997	skos:prefLabel	"deoxylimonate A-ring-lactonase"
RHEA:14997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxylimonate A-ring-lactonase"
RHEA:14997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H(+)
RHEA:65600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5,8-trihydroxycasbene + 2 NAD(+) = 2 H(+) + jolkinol C + 2 NADH
GO:0005355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose transmembrane transporter activity
GO:0005355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose permease activity
GO:0005355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose/glucose (methylgalactoside) porter activity
GO:0005355	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lactose/glucose efflux transporter activity
RHEA:24018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + vinorine => 16-epivellosimine + acetyl-CoA
RHEA:45628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] = holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]
RHEA:45628	skos:prefLabel	"L-allo-isoleucyltransferase"
RHEA:45628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-allo-isoleucyltransferase"
RHEA:53980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
REACT:R-CEL-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
REACT:R-DRE-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Danio rerio)
REACT:R-HSA-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Homo sapiens)
REACT:R-MMU-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Mus musculus)
RHEA:12907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + phosphate => alpha-D-mannose 1-phosphate + GDP + H(+)
RHEA:69318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allyl thiocyanate + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate
REACT:R-DRE-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Danio rerio)
RHEA:34747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine + ATP = 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)
REACT:R-SSC-193684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 recruits an atypical PKC (Sus scrofa)
REACT:R-SSC-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Sus scrofa)
RHEA:68577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + xanthine(out) => ADP + H(+) + phosphate + xanthine(in)
RHEA:22771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenyl-3-ketovalidamine <=> 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one
RHEA:55823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine
RHEA:26027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine + O2 = 3-aminopropanal + H2O2 + N-acetylputrescine
REACT:R-XTR-8854981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 in the RET complex is phosphorylated (Xenopus tropicalis)
EC:1.17.4.1	skos:prefLabel	"ribonucleoside-diphosphate reductase"
EC:1.17.4.1	skos:altLabel	"ribonucleotide reductase"
EC:1.17.4.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonucleoside-diphosphate reductase"
REACT:R-RNO-873924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IFNGR1 by JAK kinases (Rattus norvegicus)
REACT:R-GGA-375384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bombesin-like receptors bind bombesin homologues (Gallus gallus)
RHEA:46867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
REACT:R-CFA-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Canis familiaris)
RHEA:68282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-pentanoyl-L-seryl-[protein] => L-seryl-[protein] + pentanoyl-CoA
REACT:R-DME-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Drosophila melanogaster)
EC:1.3.1.24	skos:prefLabel	"biliverdin reductase"
EC:1.3.1.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biliverdin reductase"
REACT:R-SPO-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Schizosaccharomyces pombe)
RHEA:47472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH = (3E)-tetradecenoyl-CoA + NADP(+)
REACT:R-GGA-372980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinylCoA + GDP + Pi <=> succinate + CoASH + GTP (Gallus gallus)
RHEA:38852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + tetracenomycin F2 => H2O + tetracenomycin F1
REACT:R-XTR-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Xenopus tropicalis)
REACT:R-SSC-114259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase‑9 to caspase‑9 (Sus scrofa)
REACT:R-CEL-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:43978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2
RHEA:63836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + O2 = (2R)-2-hydroperoxyhexadecanoate
REACT:R-PFA-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)
RHEA:43284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate
RHEA:34551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(II)yrinate c monoamide + H2O + L-glutamine = ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate
REACT:R-HSA-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
RHEA:20993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxytabersonine + S-adenosyl-L-methionine => 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-174741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Rattus norvegicus)
RHEA:22636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + H2O = dCMP + diphosphate + H(+)
RHEA:71581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP(in) + CDP-L-ribitol(out) => CDP(out) + CDP-L-ribitol(in)
RHEA:47135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinal + H2O + NAD(+) <=> 11-cis-retinoate + 2 H(+) + NADH
REACT:R-BTA-6804596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1:CYCS binds APIP (Bos taurus)
RHEA:61054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-5638012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D dissociates from ARL13B:INPP5E (Mus musculus)
REACT:R-CEL-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)
RHEA:32481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-diiodo-L-tyrosine + H(+) + 2 NADPH => 2 iodide + L-tyrosine + 2 NADP(+)
REACT:R-HSA-8875659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Homo sapiens)
REACT:R-CFA-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Canis familiaris)
REACT:R-CFA-9021079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs:CAVs translocate to plasma membrane (Canis familiaris)
RHEA:64779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanylpentan-1-ol-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol
RHEA:56042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)
REACT:R-HSA-193792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)
REACT:R-MMU-114560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adhesion of integrin alphaIIbbeta3 to fibrin network (Mus musculus)
REACT:R-BTA-9632412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 is recruited to methylated ESR1 (Bos taurus)
REACT:R-RNO-390595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Troponin-C (Rattus norvegicus)
RHEA:31888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => tirucalladienol
RHEA:50263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione <=> (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate
RHEA:27421	skos:altLabel	"AFS1"
RHEA:27421	skos:altLabel	"(E,E)-alpha-farnesene synthase"
RHEA:27421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate
RHEA:27421	skos:prefLabel	"alpha-farnesene synthase"
RHEA:27421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-farnesene synthase"
REACT:R-BTA-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
REACT:R-CFA-9701000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1:BARD1 heterodimer autoubiquitinates (Canis familiaris)
EC:1.9.3.-	skos:prefLabel	"With oxygen as acceptor"
EC:1.9.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
REACT:R-CFA-174439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)
REACT:R-CEL-9603983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeX to form LeY (Caenorhabditis elegans)
REACT:R-CEL-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)
REACT:R-SSC-9020275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DHA to 17(S)-Hp-DHA (Sus scrofa)
REACT:R-BTA-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Bos taurus)
REACT:R-GGA-159729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)
RHEA:51764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + phlorisovalerophenone = 4-prenylphlorisovalerophenone + diphosphate
REACT:R-DRE-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Danio rerio)
RHEA:68676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) = adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)
RHEA:16903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-4-acetamido-2-aminobutanoate + CoA + H(+) => acetyl-CoA + L-2,4-diaminobutanoate
RHEA:70969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out) => 3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in)
GO:0070892	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lipoteichoic acid receptor activity
GO:0070892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoteichoic acid immune receptor activity
REACT:R-RNO-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Rattus norvegicus)
RHEA:42707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hercynine + L-cysteine + O2 <=> H2O + S-(hercyn-2-yl)-L-cysteine S-oxide
REACT:R-GGA-9018573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds activated EGFR (Gallus gallus)
RHEA:53570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:38749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine
RHEA:67725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP(out) + CMP-N-acetyl-beta-neuraminate(in) => CMP(in) + CMP-N-acetyl-beta-neuraminate(out)
RHEA:20744	skos:altLabel	"prostaglandin-D 15-dehydrogenase (NADP(+))"
RHEA:20744	skos:prefLabel	"15-hydroxyprostaglandin-D dehydrogenase (NADP(+))"
RHEA:20744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"15-hydroxyprostaglandin-D dehydrogenase (NADP(+))"
RHEA:20744	skos:altLabel	"prostaglandin-D 15-dehydrogenase (NADP+)"
RHEA:20744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin D2 = 15-oxoprostaglandin D2 + H(+) + NADPH
REACT:R-CFA-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Canis familiaris)
REACT:R-SSC-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Sus scrofa)
REACT:R-DRE-72095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internal Methylation of mRNA (Danio rerio)
REACT:R-HSA-452338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TDGF1 (CRIPTO) (Homo sapiens)
REACT:R-GGA-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Gallus gallus)
REACT:R-RNO-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Rattus norvegicus)
REACT:R-GGA-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Gallus gallus)
RHEA:62125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + GTP => a 2'-deoxyribonucleoside 5'-diphosphate + GDP
EC:1.1.1.322	skos:prefLabel	"(-)-endo-fenchol dehydrogenase"
EC:1.1.1.322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-endo-fenchol dehydrogenase"
RHEA:40330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:49593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA
REACT:R-XTR-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)
REACT:R-MMU-870477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Mus musculus)
RHEA:45571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparosan](n) <=> [acharan](n)
RHEA:34774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) <=> a 3-oxosteroid + CO2 + NADPH
GO:0019905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	syntaxin-6 binding
GO:0019905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	syntaxin-2 binding
GO:0019905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	syntaxin-5 binding
GO:0019905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syntaxin binding
GO:0019905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	syntaxin-13 binding
GO:0140842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity
REACT:R-RNO-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Rattus norvegicus)
RHEA:44916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-decadienoyl-CoA + H(+) + NADPH = (3E)-decenoyl-CoA + NADP(+)
REACT:R-BTA-202706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha4beta1 binds JAM2:JAM3 (Bos taurus)
REACT:R-BTA-212004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Bos taurus)
REACT:R-SCE-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Saccharomyces cerevisiae)
REACT:R-DRE-428518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glypican-1 (GPC1) binds SLIT2 (Danio rerio)
RHEA:72367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + succinate(in) = estrone 3-sulfate(in) + succinate(out)
REACT:R-BTA-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Bos taurus)
RHEA:30415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 NADPH + O2 + octadecanal = formate + H2O + heptadecane + 2 NADP(+)
RHEA:31084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-muramoyl-L-alanine => L-alanine + N-acetyl-D-muramate
REACT:R-CFA-5668545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK autophosphorylates on T559 (Canis familiaris)
REACT:R-CFA-2160915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor-mediated uptake of HA (Canis familiaris)
RHEA:54017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
REACT:R-HSA-2900756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 HD+PEST domain mutants bind JAG2 (Homo sapiens)
REACT:R-BTA-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Bos taurus)
REACT:R-CEL-8878056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds EP300 (Caenorhabditis elegans)
GO:0008869	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactonate hydro-lyase activity
GO:0008869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactonate dehydratase activity
GO:0008869	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactonate dehydrase activity
GO:0008869	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)
GO:0008869	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactonate dehydratase activity
REACT:R-HSA-8863858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)
REACT:R-RNO-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Rattus norvegicus)
REACT:R-BTA-204947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF migrates to the nucleus (Bos taurus)
REACT:R-MMU-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Mus musculus)
REACT:R-CFA-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)
REACT:R-MMU-4093327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHA binds TIAM1 (Mus musculus)
RHEA:53445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:14115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-DNA + phosphate => a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O
REACT:R-BTA-8855508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Bos taurus)
REACT:R-SCE-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Saccharomyces cerevisiae)
REACT:R-XTR-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Xenopus tropicalis)
RHEA:13756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-glutamate + NAD(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADH
REACT:R-SSC-417858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y14 receptor can bind to UDP-glucose (Sus scrofa)
RHEA:56209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)
RHEA:44593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-6798138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the CASP10 gene (Homo sapiens)
RHEA:53383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(16) in tRNA + NAD(+) <=> H(+) + NADH + uridine(16) in tRNA
REACT:R-SCE-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Saccharomyces cerevisiae)
RHEA:67933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + desmosterol(in) + H2O => ADP + desmosterol(out) + H(+) + phosphate
REACT:R-GGA-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)
RHEA:34865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyadipyl-CoA => (Z)-2,3-didehydroadipyl-CoA + H2O
RHEA:46920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) = CO2 + styrene
RHEA:65862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyandrostan-1,3-dione + AH2 => A + Delta(1)-dihydrotestosterone + H2O
RHEA:53768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholate + allodeoxycholoyl-CoA = allocholoyl-CoA + allodeoxycholate
GO:0061840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity ferrous iron transmembrane transporter activity
GO:0061840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity ferrous uptake transmembrane transporter activity
GO:0061840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity ferrous iron uptake transmembrane transporter activity
REACT:R-HSA-202241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SLP-76 to Gads (Homo sapiens)
EC:3.1.1.72	skos:prefLabel	"acetylxylan esterase"
EC:3.1.1.72	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylxylan esterase"
REACT:R-RNO-2855125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-1 binds to molecular patterns on the target cell surface (Rattus norvegicus)
REACT:R-SSC-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)
REACT:R-DME-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Drosophila melanogaster)
REACT:R-RNO-159046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Rattus norvegicus)
REACT:R-SPO-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
GO:0015661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine exporter activity
GO:0015661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity
GO:0015661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine efflux transmembrane transporter activity
REACT:R-DRE-445752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Danio rerio)
REACT:R-DRE-6785361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of FANCD2:FANCI (Danio rerio)
REACT:R-XTR-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Xenopus tropicalis)
REACT:R-DME-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Drosophila melanogaster)
GO:0030547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling receptor inhibitor activity
GO:0030547	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	receptor inhibitor activity
REACT:R-BTA-2161917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15S-HpETE to LXA4/B4 (Bos taurus)
REACT:R-DRE-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Danio rerio)
RHEA:29962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
REACT:R-GGA-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Gallus gallus)
REACT:R-XTR-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Xenopus tropicalis)
RHEA:28251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + malonyl-CoA => acetoacetyl-CoA + CO2 + CoA
REACT:R-XTR-376851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Xenopus tropicalis)
REACT:R-GGA-1604722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP9 by proteases (Gallus gallus)
REACT:R-DME-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Drosophila melanogaster)
REACT:R-HSA-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Homo sapiens)
REACT:R-XTR-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Xenopus tropicalis)
RHEA:23236	skos:altLabel	"protein methylesterase"
RHEA:23236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-glutamate methylesterase"
RHEA:23236	skos:altLabel	"chemotaxis-specific methylesterase"
RHEA:23236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol
RHEA:23236	skos:altLabel	"CheB methylesterase"
RHEA:23236	skos:prefLabel	"protein-glutamate methylesterase"
RHEA:23236	skos:altLabel	"protein methyl-esterase"
RHEA:23236	skos:altLabel	"protein carboxyl methylesterase"
RHEA:23236	skos:altLabel	"methyl-accepting chemotaxis protein methyl-esterase"
RHEA:23236	skos:altLabel	"PME"
RHEA:23236	skos:altLabel	"methylesterase CheB"
REACT:R-BTA-4793911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates HSF1 (Bos taurus)
GO:0018546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrobenzene nitroreductase activity
RHEA:31375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pyrrole-2-carboxylate = 1H-pyrrole + CO2
RHEA:61407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(D-ribulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine
RHEA:12338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + glycolate => carboxymethoxysuccinate
RHEA:70403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 3-oxosphinganine = CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine
REACT:R-SSC-749448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Sus scrofa)
REACT:R-MMU-2530501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTA:FNTB transfers FARN to GNGT1 (Mus musculus)
REACT:R-DRE-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Danio rerio)
REACT:R-GGA-727819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 phosphorylates MKK6 (Gallus gallus)
REACT:R-DRE-9611721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1-agonists bind ADRB1 (Danio rerio)
RHEA:62728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide B + bromide + FAD + 2 H(+) = (+)-malbrancheamide D + FADH2
REACT:R-GGA-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Gallus gallus)
REACT:R-HSA-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Homo sapiens)
RHEA:41335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate
RHEA:38193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone
REACT:R-BTA-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Bos taurus)
REACT:R-HSA-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Homo sapiens)
REACT:R-CFA-198440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Canis familiaris)
GO:0008048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium sensitive guanylate cyclase activator activity
REACT:R-BTA-2453863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRA6 transports atROL from extracellular region to cytosol (Bos taurus)
REACT:R-DRE-9024993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Danio rerio)
REACT:R-XTR-5218814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 autophorylates (Xenopus tropicalis)
REACT:R-RNO-6798374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DYRK2 phosphorylates TP53 (Rattus norvegicus)
RHEA:46318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+) => GDP-N,N'-diacetylbacillosamine + H2O
RHEA:23043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + acetyl-CoA + H2O <=> (R)-2-ethylmalate + CoA + H(+)
REACT:R-MMU-8877192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds FOXP3 (Mus musculus)
RHEA:32875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + H2O = a fatty acid + glycerol + H(+)
RHEA:33613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methanol + salicylate => H2O + methyl salicylate
RHEA:71567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphomethyl-dUMP in DNA + L-serine = 5-O-(L-seryl)-dTMP in DNA + phosphate
REACT:R-CFA-77271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Canis familiaris)
RHEA:54760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide = 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate
REACT:R-BTA-6814675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Bos taurus)
REACT:R-SSC-450984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Sus scrofa)
EC:6.2.1.51	skos:altLabel	"4-hydroxyphenylalkanoate adenylase"
EC:6.2.1.51	skos:prefLabel	"4-hydroxyphenylalkanoate adenylyltransferase FadD29"
EC:6.2.1.51	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylalkanoate adenylyltransferase FadD29"
RHEA:60389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)
RHEA:36960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribono-1,4-lactone + H(+) + NADH => D-ribose + NAD(+)
REACT:R-SSC-9700998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 disrupts the BRCA1:BARD1 heterodimer (Sus scrofa)
RHEA:53536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate
GO:0019213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Homo sapiens)
GO:0019213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylase activity
RHEA:37385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA
REACT:R-HSA-9712195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO2 dimer binds Ca2+ (Homo sapiens)
REACT:R-XTR-5661115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Xenopus tropicalis)
REACT:R-MMU-5696049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRM hydrolyses ADP-ribose to R5P and AMP (Mus musculus)
REACT:R-BTA-3321883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSL acetylates histone H4 (Bos taurus)
RHEA:68410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuberate + CO2 + NADH => (2R,3S)-iso(homo)3citrate + NAD(+)
RHEA:21433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate
REACT:R-HSA-9695831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 binds type II TKI (Homo sapiens)
RHEA:63035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acylamide + H2O <=> a fatty acid + NH4(+)
RHEA:10247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-fumarylacetoacetate + H2O <=> acetoacetate + fumarate + H(+)
REACT:R-GGA-5690845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNIPs bind TNFAIP3 (A20) (Gallus gallus)
REACT:R-SSC-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Sus scrofa)
REACT:R-HSA-9712183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADCY3:GNAL:GTP converts ATP to cAMP (Homo sapiens)
RHEA:40642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)
RHEA:65828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neryl diphosphate = diphosphate + nerol
REACT:R-RNO-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Rattus norvegicus)
RHEA:17935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 7-hydroxyisoflavone + S-adenosyl-L-methionine
REACT:R-SSC-1234164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Sus scrofa)
RHEA:62253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + Zn(2+)(out) => 2 hydrogencarbonate(in) + Zn(2+)(in)
RHEA:28385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine <=> D-glucose 6-phosphate + L-lysine
REACT:R-CFA-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Canis familiaris)
GO:1990640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-2,4,5-triphosphate 5-phosphatase activity
RHEA:43342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]
RHEA:15690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-2,4-diaminobutanoate => CO2 + propane-1,3-diamine
REACT:R-HSA-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)
REACT:R-RNO-4420117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR2 autophosphorylates (Rattus norvegicus)
REACT:R-MMU-73729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of SL1 (Mus musculus)
REACT:R-SSC-8952807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dissociates after IL12:IL12R interaction (Sus scrofa)
REACT:R-BTA-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Bos taurus)
GO:0015633	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	zinc transporting ATPase activity
GO:0015633	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP-dependent zinc transmembrane transporter activity
GO:0015633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type zinc transporter activity
GO:0015633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc porter activity
GO:0015633	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-coupled zinc transmembrane transporter activity
GO:0015633	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	zinc-transporting ATPase activity
RHEA:70138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Drosophila melanogaster)
GO:0042410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-carboxyhexanoate:CoA ligase (AMP-forming)
GO:0042410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + heptanedioate = 6-carboxyhexanoyl-CoA + AMP + diphosphate
GO:0042410	skos:altLabel	"6-carboxyhexanoyl-CoA synthetase"
GO:0042410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-carboxyhexanoate--CoA ligase"
GO:0042410	skos:altLabel	"Pimeloyl-CoA synthetase"
GO:0042410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-carboxyhexanoyl-CoA synthetase activity
GO:0042410	skos:prefLabel	"6-carboxyhexanoate--CoA ligase"
GO:0042410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pimelyl-CoA synthetase activity
GO:0042410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pimeloyl-CoA synthetase activity
GO:0042410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoate-CoA ligase activity
REACT:R-GGA-174121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Securin with Cdc20:APC/C complex (Gallus gallus)
GO:1905334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sae3-Mei5 complex binding
GO:1905334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Swi5-Sfr1 complex binding
REACT:R-CFA-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Canis familiaris)
REACT:R-RNO-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)
REACT:R-CFA-9032073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-phosphorylated FRS2 binds GRB2 (Canis familiaris)
RHEA:22668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP
RHEA:10235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine 5'-monophosphate + diphosphate <=> 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate
RHEA:53113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH
REACT:R-CFA-446634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 is activated by autophosphorylation (Canis familiaris)
RHEA:48987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + glyoxylate + succinate
REACT:R-HSA-2972978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter (Homo sapiens)
REACT:R-SSC-444654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled bile acid receptor binds lithocholic acid (Sus scrofa)
RHEA:14568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-XTR-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Xenopus tropicalis)
REACT:R-BTA-201639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of GAS2 (Bos taurus)
GO:0102148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-D-galactosaminidase activity
RHEA:60324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(36) N-trimethyltransferase"
RHEA:60324	skos:prefLabel	"[histone H3]-lysine(36) N-trimethyltransferase"
RHEA:60324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine
RHEA:16994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] => 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]
RHEA:45098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:32622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin
GO:0106330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialate 9-O-acetylesterase activity
REACT:R-RNO-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Rattus norvegicus)
GO:0050129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-citryl-L-glutamate amidohydrolase activity
GO:0050129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-formyl-L-glutamate amidohydrolase activity
GO:0050129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-citryl-L-glutamate hydrolase activity
GO:0050129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylglutamate deformylase activity
GO:0050129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-formylglutamate hydrolase activity
GO:0050129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formylglutamate deformylase activity
GO:0050129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-citrylglutamate amidase activity
GO:0050129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-citryl-L-glutamate-hydrolyzing enzyme
GO:0050129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-citryl-L-glutamate amidase activity
RHEA:40768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside R1 + H2O => (20S)-ginsenoside Rg1 + D-xylose
RHEA:71686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + L-aspartyl-glycine(out) <=> 2 H(+)(in) + L-aspartyl-glycine(in)
RHEA:59625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(4-aminobutanoyl)-L-ornithine => 4-aminobutanoate + L-ornithine
REACT:R-SSC-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Sus scrofa)
REACT:R-HSA-9634943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-CDK5R1 binds CDK5 (Homo sapiens)
REACT:R-HSA-2466718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRPE dissociates to atRAL and PE (Homo sapiens)
REACT:R-MMU-8849646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK5(490-624) binds KLK5 (Mus musculus)
RHEA:21849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide
RHEA:59728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ethylmalonyl-CoA = (2S)-ethylmalonyl-CoA
REACT:R-HSA-9668023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to FVIII (Homo sapiens)
REACT:R-RNO-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Rattus norvegicus)
REACT:R-BTA-158784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Bos taurus)
RHEA:44145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-methionine => CoA + H(+) + N(alpha)-acetyl-L-methionine
RHEA:69274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allyl isothiocyanate + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate
REACT:R-HSA-168950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR6:TLR2 is recruited to ligand:CD14:CD36 (Homo sapiens)
REACT:R-HSA-381545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)
REACT:R-SPO-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Schizosaccharomyces pombe)
REACT:R-XTR-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Xenopus tropicalis)
RHEA:33641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + tetracosanoyl-CoA => ATP + CoA + tetracosanoate
REACT:R-RNO-5662986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds copper (Rattus norvegicus)
RHEA:26398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 O2 => 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde
REACT:R-CFA-9684068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD binds cardiac glycosides (Canis familiaris)
REACT:R-SCE-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Saccharomyces cerevisiae)
REACT:R-DME-2186767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SKI/SKIL (Drosophila melanogaster)
RHEA:29138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 2 H(+)(in) + nitrate <=> a menaquinone + 2 H(+)(out) + H2O + nitrite
REACT:R-SSC-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Sus scrofa)
RHEA:53127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene <=> delta-carotene
RHEA:52682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-L-alpha-phenylglycine => acetyl-CoA + L-alpha-phenylglycine
RHEA:33033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + NAD(+) => H(+) + keto-D-fructose + NADH
RHEA:62783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-SCE-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Saccharomyces cerevisiae)
RHEA:57732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-7,8-dihydroretinol = AH2 + all-trans-retinol
RHEA:15755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate => GTP + IMP + L-aspartate
REACT:R-DRE-8857583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by PTK6 (Danio rerio)
RHEA:31407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diaponeurosporene + FAD + H(+) = all-trans-4,4'-diapolycopene + FADH2
REACT:R-CFA-914018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Canis familiaris)
RHEA:50181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate
RHEA:24988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] = calcitroate + H2O + 2 oxidized [adrenodoxin]
RHEA:55826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide f + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide d
REACT:R-HSA-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Homo sapiens)
GO:0016755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Aminoacyltransferases"
GO:0016755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring amino-acyl groups
GO:0016755	skos:prefLabel	"Aminoacyltransferases"
GO:0016755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacyltransferase activity
EC:3.1.21.2	skos:altLabel	"endonuclease IV"
EC:3.1.21.2	skos:prefLabel	"deoxyribonuclease IV"
EC:3.1.21.2	skos:altLabel	"endodeoxyribonuclease IV (phage T4-induced)"
EC:3.1.21.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyribonuclease IV"
EC:3.1.21.2	skos:altLabel	"endonuclease II"
EC:3.1.21.2	skos:altLabel	"deoxyribonuclease IV (phage T4-induced)"
GO:0033405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCU codon-amino acid adaptor activity
GO:0033405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine tRNA
GO:0033405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCT codon-amino acid adaptor activity
REACT:R-DRE-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Danio rerio)
REACT:R-HSA-9670620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective DAXX does not bind ATRX (Homo sapiens)
RHEA:29662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine(in) <=> O-acetyl-L-serine(out)
REACT:R-HSA-5655347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-CEL-377186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Caenorhabditis elegans)
RHEA:70304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine
REACT:R-HSA-8956458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNLS:FAD oxidises dh-beta-NAD to NAD+ (Homo sapiens)
REACT:R-XTR-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)
RHEA:48102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine
RHEA:65175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z,5E)-dodecadienoyl-CoA + H2O <=> (3Z,5E)-dodecadienoate + CoA + H(+)
RHEA:67490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-5617413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)
REACT:R-HSA-936390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD mediated deubiquitination of DDX58 (RIG-I) (Homo sapiens)
RHEA:50670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose
RHEA:38274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA <=> 3-methylfumaryl-CoA + H2O
RHEA:56280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] = AMP + L-prolyl-[peptidyl-carrier protein]
GO:0035100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone binding
REACT:R-BTA-8864125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Bos taurus)
REACT:R-HSA-5654573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds SHC1 (Homo sapiens)
REACT:R-DRE-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Danio rerio)
REACT:R-DRE-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Danio rerio)
REACT:R-MMU-508162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Mus musculus)
REACT:R-CFA-9700175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates SHC1 (Canis familiaris)
REACT:R-SSC-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Sus scrofa)
REACT:R-SSC-216068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with Tenascin-C (Sus scrofa)
REACT:R-DME-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Drosophila melanogaster)
RHEA:70957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-glutamate(out) => H(+)(in) + L-glutamate(in)
REACT:R-DRE-173597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)
RHEA:31495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP
RHEA:31495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosylceramide beta-1,4-galactosyltransferase"
RHEA:31495	skos:altLabel	"lactosylceramide synthase"
RHEA:31495	skos:prefLabel	"glucosylceramide beta-1,4-galactosyltransferase"
RHEA:71980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene A
RHEA:18576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + H(+) + O2 <=> chelirubine + H2O2
REACT:R-DME-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Drosophila melanogaster)
REACT:R-RNO-9749505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC14 binds IKBKB and CHUK (Rattus norvegicus)
REACT:R-RNO-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Rattus norvegicus)
REACT:R-SSC-5696968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP20, USP33 deubiquitinate ADRB2 (Sus scrofa)
GO:0031694	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-2A adrenergic receptor ligand
GO:0031694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2A adrenergic receptor binding
RHEA:59790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH => H2O + NAD(+) + pseudopaline
REACT:R-RNO-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Rattus norvegicus)
RHEA:12747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-hydroxyacid + H(+) => a 1,4-lactone + H2O
RHEA:21844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + phenylacetyl-CoA = CoA + H(+) + N(2)-phenylacetyl-L-glutamine
RHEA:21844	skos:prefLabel	"glutamine N-phenylacetyltransferase"
RHEA:21844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamine N-phenylacetyltransferase"
REACT:R-HSA-1483209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is converted to BMP (Homo sapiens)
RHEA:71358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) <=> 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)
REACT:R-MMU-373086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR10 binds CCL27 and 28 ligands (Mus musculus)
RHEA:17633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate
RHEA:17633	skos:prefLabel	"beta-glucuronidase"
RHEA:17633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-glucuronidase"
RHEA:68015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypoxanthine + O2 <=> H2O2 + xanthine
REACT:R-DDI-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Dictyostelium discoideum)
RHEA:17547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin] => [protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin]
REACT:R-DRE-211968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2W1 oxidises INDOL (Danio rerio)
RHEA:54766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine
REACT:R-MMU-5654591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)
RHEA:58757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)
REACT:R-MMU-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)
REACT:R-XTR-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Xenopus tropicalis)
REACT:R-BTA-2473596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP15 (Bos taurus)
REACT:R-DRE-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Danio rerio)
RHEA:49214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-CFA-3222237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMYD2 methylates TP53 (Canis familiaris)
REACT:R-RNO-174916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of N-glucuronides (Rattus norvegicus)
RHEA:14152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP
REACT:R-DRE-193684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 recruits an atypical PKC (Danio rerio)
RHEA:45137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O
REACT:R-BTA-5692315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OX40L binds OX40 (Bos taurus)
REACT:R-SSC-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Sus scrofa)
REACT:R-MMU-8944250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXV (Mus musculus)
REACT:R-SPO-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Schizosaccharomyces pombe)
REACT:R-SSC-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Sus scrofa)
REACT:R-BTA-5693620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop formation mediated by PALB2, BRCA2 and RAD51 (Bos taurus)
REACT:R-HSA-9679029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds HCQ (Homo sapiens)
REACT:R-RNO-351876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of occludin (Rattus norvegicus)
REACT:R-RNO-2671885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers:H+ transport extracellular Na+ to cytosol (Rattus norvegicus)
REACT:R-RNO-6786072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3,p-Y641-STAT6 dissociate (Rattus norvegicus)
RHEA:16608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H2O + oxaloacetate <=> (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)
REACT:R-DME-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Drosophila melanogaster)
RHEA:68929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + heptanoate + NADPH => AMP + diphosphate + heptanal + NADP(+)
REACT:R-MMU-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Mus musculus)
GO:0102127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxoguanine deaminase activity
RHEA:10214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxopentanoate + L-glutamate => 2-oxoglutarate + 5-aminopentanoate
RHEA:22694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxybenzoate + H2O + NAD(+) => 3-hydroxybenzoate + H(+) + NADH + O2
REACT:R-SPO-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-BTA-391152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds PTK2B (Bos taurus)
REACT:R-GGA-2327909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN binds collagen I, II, III, VI fibrils (Gallus gallus)
REACT:R-DME-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Drosophila melanogaster)
RHEA:33396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester => GMP + N(alpha)-acetyl-L-lysine methyl ester
RHEA:34057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH => festuclavine + NAD(+)
RHEA:37987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocopherol = 2-methyl-6-phytyl-1,4-benzene-1,4-diol
REACT:R-MMU-2671885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers:H+ transport extracellular Na+ to cytosol (Mus musculus)
REACT:R-SSC-447252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB1:TYK2 binds IL12RB2:JAK2 (Sus scrofa)
REACT:R-RNO-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Rattus norvegicus)
RHEA:72154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + glutarate(in) <=> estrone 3-sulfate(in) + glutarate(out)
RHEA:21373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + urethane => CO2 + ethanol + NH4(+)
RHEA:46313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + acetyl-CoA => 3,22-dioxochol-4-en-24-oyl-CoA + CoA
REACT:R-RNO-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Rattus norvegicus)
REACT:R-XTR-204779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang1 (Xenopus tropicalis)
REACT:R-RNO-202307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Change of PKC theta conformation (Rattus norvegicus)
REACT:R-RNO-8876366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL translocates from endosome lumen to lysosome lumen (Rattus norvegicus)
RHEA:10724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
RHEA:10907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A <=> AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide
REACT:R-MMU-3318486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Mus musculus)
RHEA:10952	skos:prefLabel	"tartronate O-hydroxycinnamoyltransferase"
RHEA:10952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + hydroxymalonate = (E)-sinapoyltartronate + CoA
RHEA:10952	skos:altLabel	"hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase"
RHEA:10952	skos:altLabel	"tartronate sinapoyltransferase"
RHEA:10952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tartronate O-hydroxycinnamoyltransferase"
REACT:R-BTA-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Bos taurus)
REACT:R-DME-5690827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 (Drosophila melanogaster)
RHEA:50065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurochenodeoxycholate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate(out)
REACT:R-GGA-212713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLC-gamma1 dissociates from EGFR (Gallus gallus)
REACT:R-HSA-1170539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor is internalized (Homo sapiens)
RHEA:20902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl alcohol + CO2 + glycine => H(+) + H2O + N-benzyloxycarbonylglycine
GO:0008432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JUN kinase binding
GO:0008432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JNK binding
RHEA:35489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Sus scrofa)
RHEA:41994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + H(+) + NADH => 17beta-hydroxy-5alpha-androstan-3-one + NAD(+)
RHEA:33548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lanosteryl hexadecanoate => H(+) + hexadecanoate + lanosterol
RHEA:15467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + sphinganine 1-phosphate => ATP + sphinganine
RHEA:52296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamyl-tRNA(Gln) => 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP
GO:0052892	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(S)-cyanohydrin producing hydroxynitrile lyase activity
GO:0052892	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(S)-oxynitrilase activity
GO:0052892	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxynitrile lyase activity
GO:0052892	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(S)-selective hydroxynitrile lyase activity
GO:0052892	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity
GO:0052892	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(S)-hydroxynitrile lyase activity
GO:0052892	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	oxynitrilase activity
GO:0052892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic (S)-hydroxynitrile lyase activity
RHEA:14011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-chrysanthemyl diphosphate + diphosphate => 2 dimethylallyl diphosphate
RHEA:62249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetaldehyde + H2O + NADP(+) => chloroacetate + 2 H(+) + NADPH
RHEA:44630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-anticapsin + NADH => L-dihydroanticapsin + NAD(+)
RHEA:54376	skos:prefLabel	"nezukol synthase"
RHEA:54376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nezukol synthase"
RHEA:54376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O = diphosphate + nezukol
RHEA:50275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> resolvin E1
REACT:R-DME-8849094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RASA1 (Drosophila melanogaster)
REACT:R-BTA-5686074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Bos taurus)
GO:0140749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phlorizin hydrolase activity
REACT:R-SSC-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Sus scrofa)
RHEA:55013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 => (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)
REACT:R-DME-9007283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 and PRC1.6 associate with E2F6.com-1 (Drosophila melanogaster)
REACT:R-MMU-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Mus musculus)
REACT:R-XTR-2473594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP15 (Xenopus tropicalis)
RHEA:52842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP => UDP-alpha-D-glucose + vanillate
REACT:R-CEL-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Caenorhabditis elegans)
REACT:R-BTA-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Bos taurus)
REACT:R-BTA-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Bos taurus)
REACT:R-MMU-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Mus musculus)
RHEA:53584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D2 = 7-oxoresolvin D2 + H(+) + NADH
RHEA:66321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP(out) => 2',3'-cGAMP(in)
REACT:R-HSA-432143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM-1 binds PP2A (Homo sapiens)
RHEA:50754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O => 2 naphthalene-1,2,4,8-tetrol + O2
REACT:R-MMU-983146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Mus musculus)
RHEA:11667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate <=> 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)
GO:0003906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apurinic deoxyendoribonuclease activity
GO:0003906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apurinic/apyrimidinic endodeoxyribonuclease activity
GO:0003906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abasic deoxyendoribonuclease activity
GO:0003906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP deoxyendoribonuclease activity
GO:0003906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Homo sapiens)
GO:0003906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0003906	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	UV endonuclease
GO:0003906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apyrimidinic deoxyendoribonuclease activity
GO:0003906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonuclease (apurinic or apyrimidinic) activity
GO:0003906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endonuclease VIII activity
REACT:R-DME-351210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Drosophila melanogaster)
REACT:R-MMU-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Mus musculus)
RHEA:31405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diaponeurosporene + FADH2 => all-trans-4,4'-diapo-zeta-carotene + FAD + H(+)
REACT:R-DRE-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Danio rerio)
RHEA:57309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + N(5)-phospho-L-glutamine => diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine
RHEA:20855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+)(in) + H2O <=> ADP + 2 H(+)(out) + phosphate
RHEA:20819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxyglycyrrhetinate + NADP(+) <=> 3-oxoglycyrrhetinate + H(+) + NADPH
REACT:R-RNO-1234159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)
GO:0031459	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycine betaine ABC transporter
GO:0031459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled glycine betaine transporter activity
GO:0031459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent glycine betaine transporter activity
GO:0031459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine betaine(out) + H2O = ADP + glycine betaine(in) + H(+) + phosphate
GO:0031459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-trimethylglycine-transporting ATPase activity
GO:0031459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine betaine-transporting ATPase activity
GO:0031459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type glycine betaine transporter activity
REACT:R-SSC-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Sus scrofa)
RHEA:24354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (R)-3-hydroxyhexanoate + NADP(+)
REACT:R-CFA-443831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3-zeta binds Raf1 (Canis familiaris)
REACT:R-XTR-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Xenopus tropicalis)
RHEA:42758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine
REACT:R-DME-8847977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRK phosphorylates PTEN (Drosophila melanogaster)
REACT:R-XTR-74715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of insulin receptor (Xenopus tropicalis)
REACT:R-SSC-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Sus scrofa)
REACT:R-HSA-158357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIIa binds SERPING1 (Homo sapiens)
REACT:R-BTA-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Bos taurus)
REACT:R-HSA-9618021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXG1 binds FOXO:SMAD complexes (Homo sapiens)
REACT:R-BTA-5218824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds FYN (Bos taurus)
REACT:R-DRE-430021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAN2-PAN3 complex partially deadenylates mRNA (Danio rerio)
RHEA:45909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroorienticin B + dTDP-beta-L-vancosamine => chloroeremomycin + dTDP + H(+)
REACT:R-BTA-429441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK activation by SRC (Bos taurus)
REACT:R-SSC-977301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histidine is decarboxylated to histamine (Sus scrofa)
REACT:R-HSA-8983518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL35 binds IL6ST:IL6ST receptor (Homo sapiens)
GO:1904599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	advanced glycation end-product binding
REACT:R-CFA-6800797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome activates CASP2 (Canis familiaris)
RHEA:43014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobut-2-enoate + H(+) + hydrogen sulfide => L-homocysteine
REACT:R-CFA-2022851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfer GlcNAc to the heparan chain (Canis familiaris)
RHEA:22814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + NADPH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+)
REACT:R-DRE-990489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-13 is a dimer (Danio rerio)
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitogen-activated protein kinase activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MBP kinase II activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MAP kinase 2 activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MBP kinase I activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitogen activated kinase activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein phosphotransferase (MAPKK-activated) activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	extracellular signal-regulated kinase activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ERK
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAPK
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP kinase activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	stress-activated kinase activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ERK2
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MAP kinase 1 activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	stress-activated protein kinase activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SAPK
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SAP kinase activity
GO:0004707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myelin basic protein kinase activity
RHEA:22312	skos:altLabel	"methylthioribose kinase"
RHEA:22312	skos:prefLabel	"S-methyl-5-thioribose kinase"
RHEA:22312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-methyl-5-thioribose kinase"
RHEA:22312	skos:altLabel	"5-methylthioribose kinase"
RHEA:22312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(methylsulfanyl)-D-ribose + ATP = ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate
RHEA:22312	skos:altLabel	"MTR kinase"
REACT:R-RNO-420977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca permeable AMPA receptor ligand binding (Rattus norvegicus)
RHEA:24103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diisopropyl fluorophosphate + H2O <=> diisopropyl phosphate + fluoride + 2 H(+)
REACT:R-BTA-8849042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS3 (Bos taurus)
REACT:R-DRE-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Danio rerio)
GO:0036004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAF domain binding
GO:0005343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sodium/chloride-dependent organic acid cotransporter activity
GO:0005343	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sodium:dicarboxylate/tricarboxylate symporter activity
GO:0005343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organic acid:sodium symporter activity
GO:0005343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Homo sapiens)
RHEA:27880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-UMP + H(+) => 2',3'-cyclophospho-UMP + H2O
RHEA:11084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dehydro-L-gulonate decarboxylase"
RHEA:11084	skos:prefLabel	"dehydro-L-gulonate decarboxylase"
RHEA:11084	skos:altLabel	"keto-L-gulonate decarboxylase"
RHEA:11084	skos:altLabel	"3-dehydro-L-gulonate carboxy-lyase"
RHEA:11084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + H(+) = CO2 + L-xylulose
RHEA:60266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine
RHEA:12373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O => 4-oxohex-2-enedioate + H(+)
REACT:R-DRE-9013157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the plasma membrane (Danio rerio)
RHEA:40521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-BTA-5696049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRM hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
REACT:R-SSC-3296326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR1 binds LACT (Sus scrofa)
GO:0015134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexuronate transmembrane transporter activity
GO:0015134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexuronide transmembrane transporter activity
RHEA:52001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O
RHEA:18568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine
RHEA:69256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + progoitrin = (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
RHEA:39452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O
REACT:R-DRE-8848975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS1 (Danio rerio)
RHEA:64172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-altrarate = galactarate
REACT:R-XTR-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Xenopus tropicalis)
RHEA:24846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 isomaltose => cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O
RHEA:42298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP] => a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP]
RHEA:42217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA
RHEA:36133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine => (indol-3-yl)acetate + S-adenosyl-L-methionine
RHEA:58528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + H2O + NADPH = (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)
REACT:R-RNO-1433456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs (Rattus norvegicus)
REACT:R-CFA-1250280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin (Canis familiaris)
RHEA:17205	skos:prefLabel	"quercetin-3-sulfate 4'-sulfotransferase"
RHEA:17205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate
RHEA:17205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quercetin-3-sulfate 4'-sulfotransferase"
GO:0047058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin-K-epoxide reductase (warfarin-insensitive) activity
GO:0047058	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin K 2,3-epoxide reductase activity
RHEA:57774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcatechol + NAD(+) + nitrite => 3-nitrotoluene + NADH + O2
REACT:R-CFA-9701507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN6 dephosphorylates JAK3 (Canis familiaris)
REACT:R-MMU-8874208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Mus musculus)
REACT:R-DRE-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Danio rerio)
REACT:R-DRE-9677917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA inhibitors bind MAOA:FAD (Danio rerio)
REACT:R-CFA-5696457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDH2 dehydrogenates 3HBA (Canis familiaris)
REACT:R-PFA-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Plasmodium falciparum)
REACT:R-CFA-2022919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Canis familiaris)
RHEA:56679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroferuloyl-CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH
REACT:R-BTA-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Bos taurus)
REACT:R-BTA-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Bos taurus)
GO:0050079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylenecarboxylate hydratase activity, producing malonate-semialdehyde
GO:0050079	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetylenecarboxylate hydratase activity
GO:0050079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylenemonocarboxylate hydrase activity
GO:0050079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylmonocarboxylic acid hydrase activity
GO:0050079	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alkynoate hydratase activity
GO:0050079	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetylenemonocarboxylate hydratase activity
GO:0050079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate-semialdehyde dehydratase activity
GO:0050079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxopropanoate hydro-lyase (propynoate-forming)
GO:0050079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxopropanoate hydro-lyase activity
GO:0050079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylenecarboxylate hydratase activity, producing 3-oxopropanoate
RHEA:25761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ent-isokaurene => ent-copalyl diphosphate
REACT:R-HSA-2466085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from R* to release atRAL (Homo sapiens)
RHEA:44828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine
GO:0004732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal oxidase activity
GO:0004732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal:oxygen 4-oxidoreductase activity
REACT:R-SCE-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Saccharomyces cerevisiae)
RHEA:41439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (9Z-octadecenoate) + CoA
RHEA:46852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3-one + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)
RHEA:55119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)
REACT:R-RNO-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Rattus norvegicus)
RHEA:68551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + psoralen + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol
RHEA:65929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine => 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-5687123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S115 MAPKAPK5 translocates to the cytosol (Gallus gallus)
REACT:R-HSA-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Homo sapiens)
RHEA:63839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + O2 <=> (2R)-2-hydroperoxyhexadecanoate
RHEA:63943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine
REACT:R-CFA-9647660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds PIPs (Canis familiaris)
RHEA:40692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol => 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-SCE-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Saccharomyces cerevisiae)
RHEA:47676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-galactosamine = ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate
RHEA:66894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:39311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)
REACT:R-DRE-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Danio rerio)
RHEA:52797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + Ni-sirohydrochlorin => Ni(2+) + sirohydrochlorin
REACT:R-XTR-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Xenopus tropicalis)
RHEA:52965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyodeoxycholate + UDP-alpha-D-glucuronate => H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP
RHEA:30355	skos:prefLabel	"methane monooxygenase (particulate)"
RHEA:30355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methane monooxygenase (particulate)"
RHEA:30355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + methane + O2 = a quinone + H2O + methanol
REACT:R-RNO-1358797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated RNF41 binds P-USP8 (Rattus norvegicus)
REACT:R-RNO-140851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Rattus norvegicus)
GO:0103089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiohexylmalate isomerase activity
RHEA:69347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-but-1-en-1-SO-peroxol <=> (Z)-butanethial oxide
REACT:R-RNO-198440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Rattus norvegicus)
RHEA:59370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+) => 1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O
REACT:R-HSA-1470009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs (Homo sapiens)
REACT:R-RNO-9667569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,2 bind AVPR antagonists (Rattus norvegicus)
RHEA:20140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetylbaccatin III + acetyl-CoA <=> baccatin III + CoA
REACT:R-HSA-9656254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective OGG1 mutants show decreased binding to 8-oxoguanine (Homo sapiens)
REACT:R-HSA-1912355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Pre-NOTCH by FRINGE (Homo sapiens)
REACT:R-DDI-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)
RHEA:68582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-kynurenine(in) + phosphate => ATP + H2O + L-kynurenine(out)
RHEA:51619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + formate + H(+) <=> CO2 + dATP + H2O
RHEA:43829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-DDI-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Dictyostelium discoideum)
REACT:R-SSC-8848774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds DOK1 (Sus scrofa)
REACT:R-HSA-203130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OLR1 binds to oxidized LDL (Homo sapiens)
REACT:R-CFA-6804942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 homodimers auto-ubiquitinate (Canis familiaris)
REACT:R-MMU-2213248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of antigen loaded MHC II molecules to surface (Mus musculus)
REACT:R-CFA-8948034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds LDL:LRP8 (Canis familiaris)
REACT:R-CFA-2130336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial proteolyis of Ii by aspartic proteases to lip22 (Canis familiaris)
REACT:R-HSA-380303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)
REACT:R-DRE-2243926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of histidino-hydroxylysinonorleucine cross-links (Danio rerio)
REACT:R-SSC-5686578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates ABL1 (Sus scrofa)
GO:0102412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valerena-4,7(11)-diene synthase activity
REACT:R-BTA-5607724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Bos taurus)
RHEA:48594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + CO2 => a quinone + formate + H(+)
GO:0090411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brassinosteroid binding
GO:0047368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity
GO:0047368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity
GO:0047368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity
GO:0047368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity
GO:0047368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity
RHEA:60660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+)
REACT:R-GGA-444527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR is a receptor for formyl peptides (Gallus gallus)
REACT:R-MMU-382553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA7:Apo1A-mediated phospholipid efflux (Mus musculus)
REACT:R-XTR-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Xenopus tropicalis)
RHEA:29580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(in) + H(+)(in) => Fe(2+)(out) + H(+)(out)
REACT:R-DDI-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)
REACT:R-BTA-751027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Bos taurus)
REACT:R-HSA-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Homo sapiens)
RHEA:37553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-kanosamine 6-phosphate => 3-dehydro-D-glucose 6-phosphate + L-glutamate
REACT:R-CFA-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Canis familiaris)
REACT:R-BTA-375339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Bos taurus)
REACT:R-CEL-2002428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen N-propeptides (Caenorhabditis elegans)
REACT:R-SSC-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Sus scrofa)
RHEA:27577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-piperidine-3-carboxamide + H2O <=> (3R)-piperidine-3-carboxylate + NH4(+)
RHEA:27780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-octaprenylphenol + CO2 => 4-hydroxy-3-all-trans-octaprenylbenzoate + H(+)
REACT:R-SPO-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Schizosaccharomyces pombe)
REACT:R-RNO-2485182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Rattus norvegicus)
REACT:R-GGA-6784324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Gallus gallus)
REACT:R-SSC-2059926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPHP4 protein binds LATS proteins (Sus scrofa)
RHEA:33760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-fatty acyl-CoA + H(+) + NADPH => a 3-hydroxy-fatty acyl-CoA + NADP(+)
REACT:R-SCE-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Saccharomyces cerevisiae)
RHEA:45144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + CO2 + CoA + methanethiol
RHEA:45144	skos:prefLabel	"methylthioacryloyl-CoA hydratase"
RHEA:45144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylthioacryloyl-CoA hydratase"
REACT:R-SCE-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Saccharomyces cerevisiae)
REACT:R-XTR-203567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylation of eNOS (Xenopus tropicalis)
RHEA:67066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + asnovolin A => AH2 + asnovolin K
RHEA:18396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-amino-2-methylpropanoate + pyruvate <=> 2-methyl-3-oxopropanoate + L-alanine
RHEA:18788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + gibberellin A12 aldehyde + H2O <=> AH2 + gibberellin A12 + H(+)
RHEA:40564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)
GO:0032795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heterotrimeric G-protein binding
REACT:R-XTR-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Xenopus tropicalis)
REACT:R-XTR-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)
RHEA:10090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6(F)-alpha-D-galactosylsucrose + H(+) + UDP => sucrose + UDP-alpha-D-galactose
RHEA:19081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)
RHEA:60523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-cystine-bis-glycine <=> 2 glycine + L-cystine
RHEA:29441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(out) + H(+)(in) => Fe(2+)(in) + H(+)(out)
RHEA:25280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP + H2O <=> AMP + H(+)
RHEA:21629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + NADPH + O2 => acetate + androst-4-ene-3,17-dione + H2O + NADP(+)
REACT:R-DRE-983218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B:RAD51C binds single-stranded DNA (Danio rerio)
REACT:R-DME-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Drosophila melanogaster)
REACT:R-SSC-5690250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Sus scrofa)
REACT:R-CFA-8951498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Canis familiaris)
REACT:R-DME-9734475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds fibrates (Drosophila melanogaster)
REACT:R-BTA-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)
RHEA:34088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol => a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester
REACT:R-BTA-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Bos taurus)
RHEA:41688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate
EC:4.1.1.93	skos:prefLabel	"pyrrole-2-carboxylate decarboxylase"
EC:4.1.1.93	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrrole-2-carboxylate decarboxylase"
REACT:R-DDI-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Dictyostelium discoideum)
RHEA:47566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA2 (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-MMU-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Mus musculus)
RHEA:15928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrobunolol + NADP(+) <=> bunolol + H(+) + NADPH
RHEA:16952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosose
RHEA:55813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine
REACT:R-HSA-1791114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FKBP14 (Homo sapiens)
RHEA:50614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenal + H(+) + NADPH => decanal + NADP(+)
RHEA:46177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoate + ATP + CoA => 2-methylpropanoyl-CoA + AMP + diphosphate
REACT:R-DRE-2514790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by MMP14 (Danio rerio)
REACT:R-RNO-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-DRE-390886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH4 binds Hist (Danio rerio)
REACT:R-SSC-4085028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE phosphorylates ManNAc to ManNAc-6-P (Sus scrofa)
RHEA:48292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + GDP-beta-L-fucose = ganglioside Fuc-GM1 + GDP + H(+)
RHEA:13654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose => [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose
REACT:R-DME-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Drosophila melanogaster)
RHEA:37008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA
RHEA:21765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:72773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-8942099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Sus scrofa)
RHEA:70673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] => N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA
RHEA:53211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16665	skos:prefLabel	"hepoxilin-epoxide hydrolase"
RHEA:16665	skos:altLabel	"hepoxilin epoxide hydrolase"
RHEA:16665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hepoxilin-epoxide hydrolase"
RHEA:16665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate
RHEA:16665	skos:altLabel	"hepoxylin hydrolase"
RHEA:16665	skos:altLabel	"hepoxilin A3 hydrolase"
RHEA:64997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + octanoate => diphosphate + octanoyl-AMP
RHEA:54013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
RHEA:59974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-decanoyl-L-seryl-[protein] => decanoyl-CoA + L-seryl-[protein]
RHEA:21133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + xanthine => H2O2 + urate
RHEA:48870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADH
RHEA:47746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylphylloquinol + NADP(+) => demethylphylloquinone + H(+) + NADPH
REACT:R-SCE-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Saccharomyces cerevisiae)
REACT:R-MMU-5357904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Mus musculus)
REACT:R-XTR-2468041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Xenopus tropicalis)
RHEA:27441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + xylitol = D-xylose + H(+) + NADPH
RHEA:27441	skos:prefLabel	"D-xylose reductase [NAD(P)H]"
RHEA:27441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + xylitol = D-xylose + H(+) + NADH
RHEA:27441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-xylose reductase [NAD(P)H]"
RHEA:27441	skos:altLabel	"D-xylose reductase"
RHEA:27441	skos:altLabel	"xylose reductase"
REACT:R-DDI-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Dictyostelium discoideum)
EC:2.4.1.74	skos:prefLabel	"glycosaminoglycan galactosyltransferase"
EC:2.4.1.74	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycosaminoglycan galactosyltransferase"
REACT:R-CFA-111289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)
RHEA:35799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H(+)
GO:0004902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte colony-stimulating factor receptor activity
GO:0004902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte colony stimulating factor receptor activity
GO:0004902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-CSF receptor activity
GO:0004902	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CSF3R
GO:0000099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur amino acid transmembrane transporter activity
GO:0000099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphur amino acid transmembrane transporter activity
GO:0000099	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sulfur amino acid transporter activity
GO:0000099	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sulphur amino acid transporter activity
REACT:R-SCE-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Saccharomyces cerevisiae)
REACT:R-RNO-5635868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-GLI is degraded by the proteasome (Rattus norvegicus)
RHEA:66683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + coproporphyrinogen III(in) + H2O <=> ADP + coproporphyrinogen III(out) + H(+) + phosphate
RHEA:34371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-acetamide = (indol-3-yl)acetate + NH4(+)
RHEA:36428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-3222593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B demethylates H3K27me3 on p16INK4A promoter (Canis familiaris)
REACT:R-XTR-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Xenopus tropicalis)
REACT:R-RNO-4086216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII binds integrin alpha2beta1 (Rattus norvegicus)
REACT:R-CFA-8851797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 in ADRB2:GRK complex is phosphorylated (Canis familiaris)
REACT:R-CEL-5324617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:FKBP4:PTGES3 binds HSF1 trimer (Caenorhabditis elegans)
RHEA:64760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-ethyl-L-cysteine = ethanethiol + NH4(+) + pyruvate
RHEA:71960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + oxaloacetate(out) => 3 Na(+)(in) + oxaloacetate(in)
REACT:R-RNO-266315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + spherical HDL <=> LCAT:spherical HDL complex (Rattus norvegicus)
RHEA:53164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)
RHEA:34837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine
RHEA:55103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxypentanoyl-[ACP] + NADP(+)
RHEA:43741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexanoate => AMP + diphosphate + hexanoyl-CoA
GO:0099520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion antiporter activity involved in regulation of pre-synaptic membrane potential
GO:0099520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion antiporter activity involved in regulation of presynaptic membrane potential
RHEA:43964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:68101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + xylitol => H(+) + L-xylulose + NADH
REACT:R-DRE-4724284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Danio rerio)
REACT:R-SSC-211239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with chromatin (Sus scrofa)
REACT:R-RNO-69685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TP53 (Rattus norvegicus)
REACT:R-XTR-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Xenopus tropicalis)
RHEA:72940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + propanoate(out) => 2 Na(+)(in) + propanoate(in)
REACT:R-BTA-6810843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin binds periplakin (Bos taurus)
RHEA:14557	skos:prefLabel	"raucaffricine beta-glucosidase"
RHEA:14557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + raucaffricine = D-glucose + vomilenine
RHEA:14557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"raucaffricine beta-glucosidase"
GO:0102046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dichlorobenzoate-4,5-oxygenase activity
REACT:R-RNO-9603302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (peptide) binds IIa (Rattus norvegicus)
REACT:R-XTR-193065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Xenopus tropicalis)
REACT:R-RNO-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Rattus norvegicus)
GO:0015399	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	primary active transporter
GO:0015399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	primary active transmembrane transporter activity
GO:0047939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucuronate dehydrogenase activity
GO:0047939	skos:prefLabel	"glucuronate reductase"
GO:0047939	skos:altLabel	"NADP-L-gulonate dehydrogenase"
GO:0047939	skos:altLabel	"D-glucuronate dehydrogenase"
GO:0047939	skos:altLabel	"L-glucuronate reductase"
GO:0047939	skos:altLabel	"D-glucuronate reductase"
GO:0047939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronate reductase"
GO:0047939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronate dehydrogenase activity
GO:0047939	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D-glucuronate reductase activity
GO:0047939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde reductase II activity
GO:0047939	skos:altLabel	"TPN-L-gulonate dehydrogenase"
GO:0047939	skos:altLabel	"glucuronate dehydrogenase"
GO:0047939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronate reductase activity
GO:0047939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH
GO:0047939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-L-gulonate dehydrogenase activity
GO:0047939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glucuronate reductase activity
GO:0047939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPN-L-gulonate dehydrogenase activity
RHEA:71407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] = 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Danio rerio)
REACT:R-BTA-936986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
GO:0050060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-alcohol:NAD+ oxidoreductase activity
GO:0050060	skos:prefLabel	"long-chain-alcohol dehydrogenase"
GO:0050060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-alcohol dehydrogenase"
GO:0050060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty alcohol oxidoreductase activity
GO:0050060	skos:altLabel	"fatty alcohol oxidoreductase"
GO:0050060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + H2O + 2 NAD(+) = a long-chain fatty acid + 3 H(+) + 2 NADH
GO:0050060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain alcohol dehydrogenase activity
GO:0050060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-alcohol dehydrogenase activity
RHEA:54005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
GO:0070051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrinogen binding
REACT:R-GGA-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Gallus gallus)
REACT:R-DDI-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Dictyostelium discoideum)
REACT:R-BTA-5682588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 binds phosphorylated MDC1 at DNA DSBs (Bos taurus)
GO:0016691	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	haem chloroperoxidase activity
GO:0016691	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	flavin-haem chloroperoxidase activity
GO:0016691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chloroperoxidase activity
GO:0016691	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heme chloroperoxidase activity
GO:0016691	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cofactor-free chloroperoxidase activity
GO:0016691	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	flavin-heme chloroperoxidase activity
GO:0016691	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vanadium chloroperoxidase activity
GO:0016691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride peroxidase activity
GO:0016691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chloride:hydrogen-peroxide oxidoreductase
GO:0102733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	typhasterol C-23 hydroxylase activity
REACT:R-BTA-5607720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)
REACT:R-MMU-114307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SMAC (DIABLO) from mitochondria (Mus musculus)
REACT:R-CFA-6798317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Canis familiaris)
RHEA:70905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate
RHEA:67227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA
REACT:R-CFA-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
REACT:R-HSA-1482546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)
REACT:R-XTR-4719423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO3 (Xenopus tropicalis)
RHEA:50472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + H(+) + malonyl-CoA = (2-aminobenzoyl)acetyl-CoA + CO2 + CoA
RHEA:50472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthraniloyl-CoA anthraniloyltransferase"
RHEA:50472	skos:prefLabel	"anthraniloyl-CoA anthraniloyltransferase"
REACT:R-RNO-5654416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:pFRS binds GRB2:SOS1 (Rattus norvegicus)
REACT:R-SSC-202437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 (Sus scrofa)
REACT:R-HSA-5655290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
RHEA:43105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + an N-acyleicosasphinganine + O2 => A + an N-acyleicosasphing-4-enine + 2 H2O
GO:0005471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP/ATP carrier protein
GO:0005471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP/ATP translocase
GO:0005471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP/ADP exchange
GO:0005471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP/ADP exchanger
GO:0005471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine nucleotide translocase
GO:0005471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:ADP antiporter activity
RHEA:15106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + S-adenosyl-L-methionine => H(+) + kaempferide + S-adenosyl-L-homocysteine
RHEA:35985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA
RHEA:16108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3S)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O
REACT:R-DRE-3132759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds RCbl (Danio rerio)
RHEA:52796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + Ni-sirohydrochlorin = Ni(2+) + sirohydrochlorin
RHEA:52796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sirohydrochlorin nickelchelatase"
RHEA:52796	skos:prefLabel	"sirohydrochlorin nickelchelatase"
REACT:R-RNO-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Rattus norvegicus)
RHEA:53396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)
RHEA:50057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycocholate(in) + H2O => ADP + glycocholate(out) + H(+) + phosphate
REACT:R-GGA-373791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Gallus gallus)
GO:0034537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity
RHEA:54010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O
REACT:R-DRE-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Danio rerio)
REACT:R-HSA-2467738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A2E translocates to RPE cells (Homo sapiens)
REACT:R-MMU-2028651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Mus musculus)
REACT:R-SSC-352107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Sus scrofa)
REACT:R-SPO-165162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TSC2 by PKB (Schizosaccharomyces pombe)
GO:0019200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Homo sapiens)
GO:0019200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate kinase activity
REACT:R-RNO-5683964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates EYA1-4 (Rattus norvegicus)
REACT:R-MMU-74101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerization of 11c-retinyl to at-retinyl (Mus musculus)
RHEA:21338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxolactone + H(+) + NADH => NAD(+) + pyridoxal
RHEA:16896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridine + S-adenosyl-L-methionine <=> N-methylpyridinium + S-adenosyl-L-homocysteine
RHEA:31452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) => a cardiolipin + glycerol
RHEA:55872	skos:prefLabel	"FMN-dependent NADH-azoreductase"
RHEA:55872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH
RHEA:55872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FMN-dependent NADH-azoreductase"
REACT:R-SSC-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Sus scrofa)
RHEA:34844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromonapterin 3'-triphosphate + 3 H2O => 7,8-dihydromonapterin + 2 H(+) + 3 phosphate
RHEA:10327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-glycol + NADP(+) <=> a 2-hydroxycarbonyl + H(+) + NADPH
REACT:R-MMU-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Mus musculus)
RHEA:54513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peregrinol diphosphate => (13R)-9,13-epoxylabd-14-ene + diphosphate
REACT:R-DME-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Drosophila melanogaster)
RHEA:24488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-9027628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises EPA to 5-HEPE (Bos taurus)
RHEA:70761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine
REACT:R-CFA-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Canis familiaris)
REACT:R-CFA-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)
REACT:R-HSA-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Homo sapiens)
REACT:R-RNO-877198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates membrane pores that include pannexin-1 (Rattus norvegicus)
RHEA:43308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-RNO-8852580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clusterin binds C5b-C7, C8, C9 (Rattus norvegicus)
REACT:R-BTA-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Bos taurus)
REACT:R-DRE-264997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cysteine to cystine in Proinsulin (Danio rerio)
REACT:R-XTR-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Xenopus tropicalis)
REACT:R-HSA-68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
REACT:R-DDI-209821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of N-acetyl-5-HT to form melatonin (Dictyostelium discoideum)
RHEA:51202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-retinylidene-N-retinylphosphatidylethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine
REACT:R-HSA-173723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C8 binds C5b:C6:C7 (Homo sapiens)
REACT:R-DME-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Drosophila melanogaster)
RHEA:11982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis-gamma-glutamylcystine + H(+) + NADPH => 2 gamma-L-glutamyl-L-cysteine + NADP(+)
REACT:R-DME-1168638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated IKK phosphorylates I-kappaB (Drosophila melanogaster)
RHEA:44525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)
RHEA:58735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-CTP + H2O <=> 5-methyl-CMP + diphosphate + H(+)
REACT:R-DME-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Drosophila melanogaster)
RHEA:47761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)
REACT:R-BTA-9034855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK3 (Bos taurus)
GO:0140776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-containing complex destabilizing activity
GO:0140776	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein unfoldase activity
REACT:R-HSA-189384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLVRA:Zn2+, BLVRB reduce BV to BIL (Homo sapiens)
REACT:R-HSA-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Homo sapiens)
RHEA:28515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + ATP + CoA => (R)-carnitinyl-CoA + AMP + diphosphate
REACT:R-DDI-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Dictyostelium discoideum)
REACT:R-HSA-9759549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Homo sapiens)
REACT:R-DRE-983425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Danio rerio)
REACT:R-DRE-964811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5AR2 binds anaphylatoxins and thier desArginated derivatives (Danio rerio)
EC:3.4.25.1	skos:altLabel	"proteasome"
EC:3.4.25.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"proteasome endopeptidase complex"
EC:3.4.25.1	skos:altLabel	"ingensin"
EC:3.4.25.1	skos:altLabel	"Lens neutral proteinase"
EC:3.4.25.1	skos:prefLabel	"proteasome endopeptidase complex"
EC:3.4.25.1	skos:altLabel	"multicatalytic proteinase (complex)"
EC:3.4.25.1	skos:altLabel	"prosome"
EC:3.4.25.1	skos:altLabel	"macropain"
EC:3.4.25.1	skos:altLabel	"multicatalytic endopeptidase complex"
RHEA:22089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP => AMP + guanosine 3'-diphosphate 5'-triphosphate
REACT:R-HSA-5671972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT binds CDKN1B (Homo sapiens)
REACT:R-RNO-3371554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 acetylation at Lys80 (Rattus norvegicus)
REACT:R-CEL-1605591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Caenorhabditis elegans)
REACT:R-CFA-6809393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filaments bind cell-cell adhesion complexes (Canis familiaris)
REACT:R-MMU-5689000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Mus musculus)
GO:0102731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity
RHEA:25798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-methionine
RHEA:12256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arogenate + NAD(+) = CO2 + L-tyrosine + NADH
REACT:R-RNO-9706323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA2 (Rattus norvegicus)
REACT:R-RNO-9646679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded proteins bind vimentin to form aggresome (Rattus norvegicus)
REACT:R-RNO-6803719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds ZNF385A (Rattus norvegicus)
RHEA:18379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + streptomycin 3''-phosphate => ATP + streptomycin
RHEA:50949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in single-stranded DNA + NH4(+)
REACT:R-GGA-217147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of c-Abl and Arg by ATM (Gallus gallus)
REACT:R-HSA-1614362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Homo sapiens)
GO:0043721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutyryl-CoA dehydratase activity
GO:0043721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-hydroxybutyryl-CoA dehydratase activity
GO:0043721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoyl-CoA dehydratase activity
GO:0043721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoyl-CoA hydro-lyase
GO:0043721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-hydroxybutanoyl-CoA dehydratase activity
RHEA:40209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O
REACT:R-BTA-9707516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM dissociates from MetHb (Bos taurus)
RHEA:42621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylureidoacrylate + H(+) + H2O => (Z)-2-methylaminoacrylate + CO2 + NH4(+)
RHEA:41989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH
RHEA:64813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + S-(2-aminoethyl)-homocysteine => CoA + H(+) + S-(2-acetamidoethyl)-homocysteine
RHEA:35623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate + D-glutamine = gamma-D-glutamyl-D-glutamate + NH4(+)
RHEA:35623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glutamyltransferase"
RHEA:35623	skos:altLabel	"D-glutamyl transpeptidase"
RHEA:35623	skos:prefLabel	"D-glutamyltransferase"
REACT:R-HSA-9770187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion (Homo sapiens)
RHEA:13642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methane + NADPH + O2 => H2O + methanol + NADP(+)
RHEA:61358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + methotrexate(out) + phosphate => ATP + H2O + methotrexate(in)
REACT:R-HSA-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
REACT:R-CFA-2186767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SKI/SKIL (Canis familiaris)
RHEA:53900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[myosin light chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]
RHEA:14598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-RNO-8875443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates LRIG1 (Rattus norvegicus)
REACT:R-CEL-9668904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18 complex (Caenorhabditis elegans)
REACT:R-XTR-1678694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Xenopus tropicalis)
REACT:R-RNO-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Rattus norvegicus)
REACT:R-GGA-433936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 (Gallus gallus)
RHEA:35245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine thiamine triphosphate + phosphate => ADP + H(+) + thiamine diphosphate
RHEA:50389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5a,11a-dehydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrooxytetracycline + H2O + NADP(+)
RHEA:48998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-2,4-heptadienoate + H(+) => 3-methylcatechol + O2
REACT:R-XTR-9034042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Xenopus tropicalis)
REACT:R-CFA-5626227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CP110 and CEP97 dissociate from the centriole (Canis familiaris)
REACT:R-MMU-199863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate NR4A1 (NUR77) (Mus musculus)
REACT:R-SSC-199917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates CREB at Serine 133 (Sus scrofa)
RHEA:52985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] => 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]
REACT:R-HSA-1855153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Homo sapiens)
RHEA:18022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) => CMP + ganglioside GD1a (d18:1(4E)) + H(+)
RHEA:69512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-galactosamine + O2 = H(+) + H2O2 + N-acetyl-D-galactosaminate
RHEA:14306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-proline + tRNA(Pro) => AMP + diphosphate + L-prolyl-tRNA(Pro)
RHEA:30823	skos:prefLabel	"UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)"
RHEA:30823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)"
RHEA:30823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
EC:6.7.-.-	skos:prefLabel	"Forming nitrogen-nitrogen bonds"
EC:6.7.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming nitrogen-nitrogen bonds"
REACT:R-SPO-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Schizosaccharomyces pombe)
REACT:R-XTR-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:18763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacyl-sn-glycerol + H2O
REACT:R-GGA-9648089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6 and NEK7 phosphorylate EML4 (Gallus gallus)
RHEA:33176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate(in) => 4-hydroxyphenylacetate(out)
RHEA:11768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthranilate phosphoribosyltransferase"
RHEA:11768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate
RHEA:11768	skos:altLabel	"phosphoribosyl-anthranilate pyrophosphorylase"
RHEA:11768	skos:altLabel	"phosphoribosyl-anthranilate diphosphorylase"
RHEA:11768	skos:prefLabel	"anthranilate phosphoribosyltransferase"
GO:0030621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U4 snRNA binding
RHEA:29669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O(out) => H2O(in)
REACT:R-RNO-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Rattus norvegicus)
REACT:R-CFA-198563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO1 dioxygenates L-Trp to NFK (Canis familiaris)
RHEA:34607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine = a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine
RHEA:62901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)
REACT:R-HSA-5635850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters (Homo sapiens)
REACT:R-HSA-912368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)
RHEA:57355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin <=> H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]
RHEA:48099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine
RHEA:47888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
RHEA:50291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate
REACT:R-HSA-8939205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG translocates to the nucleus (Homo sapiens)
REACT:R-HSA-9021660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds membrane-associated estrogen receptors (Homo sapiens)
REACT:R-SSC-6799981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 binds bacterial peptidoglycan (Sus scrofa)
REACT:R-HSA-2730848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)
RHEA:25913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-5-ol => 5-hydroxyquinolin-2(1H)-one + AH2
REACT:R-HSA-9701000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1:BARD1 heterodimer autoubiquitinates (Homo sapiens)
REACT:R-DDI-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Dictyostelium discoideum)
REACT:R-HSA-2179274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD3 phosphorylated in the linker region (Homo sapiens)
REACT:R-CEL-191983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
REACT:R-HSA-1974676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta defensin 103 activates TLR1:TLR2 (Homo sapiens)
REACT:R-CFA-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Canis familiaris)
RHEA:32091	skos:altLabel	"desosaminyl transferase EryCIII"
RHEA:32091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-alpha-mycarosylerythronolide B desosaminyl transferase"
RHEA:32091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+)
RHEA:32091	skos:prefLabel	"3-alpha-mycarosylerythronolide B desosaminyl transferase"
RHEA:32091	skos:altLabel	"EryCIII"
RHEA:21939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + putrescine <=> H(+) + N-carbamoylputrescine + phosphate
RHEA:18912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trichlorophenol + S-adenosyl-L-methionine <=> 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine
RHEA:67878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine
RHEA:68198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoyl-3-tetradecanoylglycerol + CoA => 1,2-dihexanoylglycerol + tetradecanoyl-CoA
GO:0017161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4-trisphosphate 4-phosphatase activity
GO:0043794	skos:prefLabel	"With other acceptors"
GO:0043794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate dehydrogenase (coenzyme F420) activity
GO:0043794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate dehydrogenase (F420) activity
GO:0043794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
GO:0062202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol
GO:0062202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Labd-13(16),14-diene-9-ol synthase activity
REACT:R-GGA-174452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha on the C-strand of the telomere (Gallus gallus)
RHEA:23590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalyl-CoA + succinate => oxalate + succinyl-CoA
RHEA:19095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,18-didecarboxysiroheme + 2 CO2 => 2 H(+) + siroheme
GO:0009384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylaminodeoxymannokinase activity
GO:0009384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:N-acyl-D-mannosamine 6-phosphotransferase activity
GO:0009384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylmannosamine kinase activity
GO:0009384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylamidodeoxymannokinase activity
GO:0009384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylmannosamine kinase activity
GO:0009384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:N-acetylmannosamine 6-phosphotransferase activity
GO:0009384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylmannosamine kinase activity
GO:0009384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-D-mannosamine kinase activity
GO:0009384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylmannosamine kinase (phosphorylating)
GO:0009384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylmannosamine kinase activity
REACT:R-DRE-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Danio rerio)
RHEA:27804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-decaprenyl diphosphate + 7 diphosphate => (2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
GO:0071566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UFM1 activating enzyme activity
RHEA:10875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-L-aspartate <=> a carboxylate + L-aspartate
RHEA:56861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate => a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]
REACT:R-HSA-9026377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTF4-bound NTRK2 dimerizes (Homo sapiens)
RHEA:70663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(in) + H(+)(in) = 4-hydroxy-L-proline(out) + H(+)(out)
REACT:R-DRE-4420206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SRC-1 (Danio rerio)
REACT:R-DRE-2632521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Danio rerio)
REACT:R-MMU-73646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)
RHEA:25793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Cu(+)(in) + H2O => ADP + Cu(+)(out) + H(+) + phosphate
RHEA:19714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
RHEA:67962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine => 4-amino-L-phenylalanine + S-adenosyl-L-methionine
REACT:R-BTA-5625784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Bos taurus)
REACT:R-DRE-8852716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin, ELANE cleave C5 (Danio rerio)
REACT:R-CFA-2473596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP15 (Canis familiaris)
REACT:R-SCE-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Saccharomyces cerevisiae)
EC:2.7.12.2	skos:altLabel	"MKK"
EC:2.7.12.2	skos:altLabel	"MAPKK"
EC:2.7.12.2	skos:altLabel	"MAP2K"
EC:2.7.12.2	skos:prefLabel	"mitogen-activated protein kinase kinase"
EC:2.7.12.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mitogen-activated protein kinase kinase"
EC:2.7.12.2	skos:altLabel	"MAP kinase kinase"
EC:2.7.12.2	skos:altLabel	"MEK"
RHEA:50912	skos:altLabel	"Tar primase"
RHEA:50912	skos:prefLabel	"teichoic acid ribitol-phosphate primase"
RHEA:50912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol = 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)
RHEA:50912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"teichoic acid ribitol-phosphate primase"
REACT:R-HSA-8954082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds the PRC1 complex (Homo sapiens)
RHEA:27426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate
REACT:R-CFA-74743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-Y427-SHC1 from insulin receptor (Canis familiaris)
REACT:R-XTR-174451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of DNA2 endonuclease to the C strand (Xenopus tropicalis)
REACT:R-DME-1358789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Self-ubiquitination of RNF41 (Drosophila melanogaster)
RHEA:66157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + tyramine => CoA + H(+) + N-butanoyltyramine
RHEA:55403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) <=> archaeosine(15) in tRNA
REACT:R-BTA-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Bos taurus)
RHEA:45845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-CoA + NADP(+) => 3-oxooctanoyl-CoA + H(+) + NADPH
RHEA:58583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate <=> acetate + catharanthine + H(+)
REACT:R-HSA-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)
REACT:R-CFA-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Canis familiaris)
REACT:R-HSA-3223236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) (Homo sapiens)
REACT:R-XTR-4568848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Xenopus tropicalis)
RHEA:60089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADPH
RHEA:21376	skos:altLabel	"4-hydroxyphenylpyruvate dioxygenase II"
RHEA:21376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2
RHEA:21376	skos:prefLabel	"4-hydroxymandelate synthase"
RHEA:21376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxymandelate synthase"
REACT:R-CFA-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Canis familiaris)
REACT:R-HSA-9609740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3B (GRIN3B) (Homo sapiens)
RHEA:40495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 = N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine
RHEA:22773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuconate => 2-dehydro-3-deoxy-L-fuconate + H2O
RHEA:55187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylundecanoyl-CoA + O2 <=> 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate
RHEA:50708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
REACT:R-XTR-5638157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)
RHEA:52847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP
RHEA:14231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-5663138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds CCRN4L (NOCTURNIN) gene (Homo sapiens)
RHEA:11798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroecdysone + H2O2 => ecdysone + O2
REACT:R-CEL-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Caenorhabditis elegans)
REACT:R-CEL-193727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
REACT:R-MMU-873922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 by JAK kinases (Mus musculus)
RHEA:13903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(hydroxymethyl)urea + NH4(+) => H2O + N-(aminomethyl)urea
REACT:R-PFA-9749197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 binds to H4K20me2 (Plasmodium falciparum)
RHEA:47748	skos:prefLabel	"NADH:ubiquinone reductase (Na(+)-transporting)"
RHEA:47748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)
RHEA:47748	skos:altLabel	"Na(+)-NQR"
RHEA:47748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADH:ubiquinone reductase (Na(+)-transporting)"
RHEA:47748	skos:altLabel	"Na(+)-translocating NADH-quinone reductase"
RHEA:69057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-methyl-L-arginine + NADH + O2 => H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)
REACT:R-BTA-8852266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Bos taurus)
REACT:R-MMU-1592436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP9 by MMPs (Mus musculus)
REACT:R-SSC-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Sus scrofa)
RHEA:42788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42788	skos:prefLabel	"23S rRNA (cytidine(2498)-2'-O)-methyltransferase"
RHEA:42788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (cytidine(2498)-2'-O)-methyltransferase"
GO:0044590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulfur-molybdenum cofactor binding
GO:0044590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeMo co binding
GO:0044590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeMoco binding
REACT:R-BTA-190263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3b binds to FGF (Bos taurus)
GO:0043755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ribazole-5'-phosphate phosphohydrolase activity
GO:0043755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ribazole-5'-P phosphatase activity
GO:0043755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ribazole phosphatase activity
GO:0043755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobC
REACT:R-RNO-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Rattus norvegicus)
REACT:R-CFA-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Canis familiaris)
RHEA:13551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GDP-beta-L-fucose => beta-L-fucose 1-phosphate + GTP + H(+)
RHEA:11908	skos:altLabel	"oxidized PVA hydrolase"
RHEA:11908	skos:prefLabel	"beta-diketone hydrolase"
RHEA:11908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-diketone hydrolase"
RHEA:11908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one
RHEA:18673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]
RHEA:18673	skos:prefLabel	"receptor protein serine/threonine kinase"
RHEA:18673	skos:altLabel	"TGF-beta kinase"
RHEA:18673	skos:altLabel	"activin receptor kinase"
RHEA:18673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]
RHEA:18673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"receptor protein serine/threonine kinase"
RHEA:18673	skos:altLabel	"receptor serine/threonine protein kinase"
RHEA:18673	skos:altLabel	"receptor type II serine/threonine protein kinase"
RHEA:18673	skos:altLabel	"receptor type I serine/threonine protein kinase"
REACT:R-HSA-9702638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tandutinib-resistant FLT3 mutants don't bind tandutinib (Homo sapiens)
RHEA:24957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-muramate 6-phosphate => (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate
REACT:R-XTR-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Xenopus tropicalis)
RHEA:41173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O
REACT:R-CEL-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Caenorhabditis elegans)
REACT:R-DRE-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Danio rerio)
REACT:R-DRE-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Danio rerio)
REACT:R-BTA-9677320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS1 dimer binds PTGS1 Inhibitors (Bos taurus)
RHEA:64944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + 2 H2O = dCMP + 2 H(+) + 2 phosphate
REACT:R-DRE-6806647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Danio rerio)
RHEA:29444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanine(in) => H(+)(out) + L-alanine(out)
RHEA:69202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate
REACT:R-DME-6781899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds SIAH2 (Drosophila melanogaster)
REACT:R-BTA-9008258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 binds ESR1:estrogen:TFGA gene (Bos taurus)
REACT:R-HSA-5655243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 point and translocation mutants phosphorylate PLCG1 (Homo sapiens)
REACT:R-HSA-5655326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-MMU-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Mus musculus)
REACT:R-CFA-9611851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 bind ADR,NAd (Canis familiaris)
RHEA:48191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:47179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O
REACT:R-CFA-8875661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA3 associates with activated MET receptor (Canis familiaris)
REACT:R-DME-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Drosophila melanogaster)
RHEA:11273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + a quinone => a 2-oxocarboxylate + a quinol
REACT:R-BTA-2179415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Bos taurus)
RHEA:60184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucose(out) + H2O = ADP + D-glucose(in) + H(+) + phosphate
RHEA:15670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)
REACT:R-GGA-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Gallus gallus)
REACT:R-RNO-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Rattus norvegicus)
REACT:R-MMU-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Mus musculus)
REACT:R-XTR-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Xenopus tropicalis)
REACT:R-RNO-141202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates TYR (Rattus norvegicus)
REACT:R-XTR-9757574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDL (Xenopus tropicalis)
REACT:R-DME-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Drosophila melanogaster)
RHEA:47310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-110141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Mus musculus)
RHEA:37676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:11632	skos:altLabel	"selenocysteine beta-lyase"
RHEA:11632	skos:altLabel	"selenocysteine reductase"
RHEA:11632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-selenocysteine = A + H(+) + hydrogenselenide + L-alanine
RHEA:11632	skos:prefLabel	"selenocysteine lyase"
RHEA:11632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"selenocysteine lyase"
REACT:R-RNO-2730899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BCL10 and MALT1 (Rattus norvegicus)
REACT:R-BTA-170978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-FRS2:CRKL binds C3G (Bos taurus)
REACT:R-DME-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
REACT:R-CFA-873951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1:HSP90 binds inactive NLRP3 (Canis familiaris)
GO:0050062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acyl CoA reductase activity
GO:0050062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acyl-CoA reductase activity
GO:0050062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-fatty-acyl-CoA reductase activity
GO:0050062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)
GO:0050062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl coenzyme A reductase activity
RHEA:24687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formylmethanofuran => formate + methanofuran
REACT:R-HSA-975866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyD88 forms a complex with the activated TLR receptor (Homo sapiens)
REACT:R-RNO-9757686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDL (Rattus norvegicus)
RHEA:33700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CFA-8864569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds TFAP2C (Canis familiaris)
RHEA:16917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypyridine + H(+) + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD(+)
RHEA:16917	skos:prefLabel	"2,6-dihydroxypyridine 3-monooxygenase"
RHEA:16917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,6-dihydroxypyridine 3-monooxygenase"
RHEA:28672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate
RHEA:45213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) => CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]
RHEA:12800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + scopolamine + succinate
REACT:R-GGA-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Gallus gallus)
REACT:R-DME-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Drosophila melanogaster)
REACT:R-SCE-5686430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81 binds EME1, EME2 (Saccharomyces cerevisiae)
RHEA:65022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(2)-succinyl-L-ornithine => L-ornithine + succinyl-CoA
REACT:R-SSC-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Sus scrofa)
REACT:R-CFA-947673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanin-concentrating hormone receptors bind MCH (Canis familiaris)
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G-protein-coupled A1 adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A2B adenosine receptor activity, G protein coupled
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G-protein-coupled A3 adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G protein coupled A3 adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G-protein-coupled A2A adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A2A adenosine receptor activity, G protein coupled
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A2A adenosine receptor activity, G-protein coupled
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A2B adenosine receptor activity, G-protein coupled
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G protein coupled A1 adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P1 receptor
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A3 adenosine receptor activity, G-protein coupled
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A3 adenosine receptor activity, G protein coupled
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine receptor activity, G-protein coupled
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G-protein-coupled A2B adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A1 adenosine receptor activity, G-protein coupled
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine receptor activity, G protein coupled
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G protein coupled A2B adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A1 adenosine receptor activity, G protein coupled
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G protein coupled A2A adenosine receptor activity
GO:0001609	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	adenosine nucleotide receptor
REACT:R-BTA-8848077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAP2 (Bos taurus)
REACT:R-SSC-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Sus scrofa)
REACT:R-DME-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Drosophila melanogaster)
RHEA:66404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O + taurocholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)
REACT:R-SSC-2186771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 binds SMAD7 (Sus scrofa)
RHEA:38177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + CoA => all-trans-retinol + hexadecanoyl-CoA
REACT:R-HSA-72103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of pre-mRNPs (Homo sapiens)
GO:0050104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-gulonate:NAD+ 3-oxidoreductase activity
GO:0050104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-beta-hydroxyacid dehydrogenase activity
GO:0050104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-beta-hydroxy-acid-NAD-oxidoreductase activity
GO:0050104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-aldonic dehydrogenase activity
GO:0050104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonate 3-dehydrogenase activity
GO:0050104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-gulonic acid dehydrogenase activity
GO:0050104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-hydroxyacid dehydrogenase activity
GO:0050104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-aldonate dehydrogenase activity
RHEA:44251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:53707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine
REACT:R-HSA-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Homo sapiens)
REACT:R-CFA-9007882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 is cleaved (Canis familiaris)
RHEA:51611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + pyruvate <=> (R)-lactate + 2-oxoglutarate
RHEA:39407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)
RHEA:48638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
RHEA:12369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + A => 2,5-didehydro-D-gluconate + AH2
REACT:R-BTA-419426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cannabinoid receptors can bind cannabinoids (Bos taurus)
REACT:R-DRE-2176491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L binds phosphorylated linker region of SMAD2/3 (Danio rerio)
RHEA:38081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA
RHEA:24511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin E2
REACT:R-SSC-8953013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 binds E2F8 (Sus scrofa)
REACT:R-RNO-9020274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Rattus norvegicus)
REACT:R-HSA-9635927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF4 and a CEBP protein bind the TRIB3 promoter (Homo sapiens)
REACT:R-RNO-8937744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-7Y-RUNX1 (Rattus norvegicus)
REACT:R-DME-1295613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds GRB2 (Drosophila melanogaster)
RHEA:35013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fucose(out) + H(+)(out) => D-fucose(in) + H(+)(in)
REACT:R-HSA-193455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Homo sapiens)
RHEA:64768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-3-(hexan-1-ol)-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol
REACT:R-BTA-8853792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET tyrosine phosphorylation (Bos taurus)
RHEA:23078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorobenzoyl-CoA + NADPH => 4-chlorobenzoyl-CoA + chloride + NADP(+)
GO:0015516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tartrate:succinate antiporter activity
RHEA:42897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine
REACT:R-BTA-2022403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)
GO:0033821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity
GO:0033821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:DNA beta-D-glucosyltransferase activity
GO:0033821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA beta-glucosyltransferase activity
GO:0033821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:DNA beta-D-glucosyltransferase activity
GO:0033821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucose-DNA beta-glucosyltransferase activity
GO:0033821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T4 phage beta-glucosyltransferase activity
GO:0033821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T4-HMC-beta-glucosyl transferase activity
GO:0033821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T4-beta-glucosyl transferase activity
GO:0034041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type sterol transporter activity
GO:0034041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-coupled sterol transmembrane transporter activity
GO:0034041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled sterol transmembrane transporter activity
GO:0034041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol-transporting ATPase activity
GO:0034041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent sterol transmembrane transporter activity
RHEA:53097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine
RHEA:36652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-desmethylnovobiocic acid + S-adenosyl-L-methionine => H(+) + novobiocic acid + S-adenosyl-L-homocysteine
REACT:R-MMU-204861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shc1 (Mus musculus)
RHEA:51315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine
REACT:R-MMU-2514867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Mus musculus)
RHEA:59655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotetraono-1,5-lactone + H2O <=> D-xylotetraonate + H(+)
REACT:R-HSA-9664983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)
RHEA:30485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-3215152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter (Homo sapiens)
RHEA:37830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate
REACT:R-CFA-373700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-9 binds DCC:DIP13alpha complex (Canis familiaris)
REACT:R-RNO-2168889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin-related Protein binds Hemoglobin (Rattus norvegicus)
REACT:R-MMU-201677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Mus musculus)
REACT:R-SCE-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Saccharomyces cerevisiae)
RHEA:57932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate
GO:0033964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosphingolipid deacylase activity
GO:0033964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycosphingolipid amidohydrolase activity
GO:0033964	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycosphingolipid ceramide deacylase activity
RHEA:11037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + quaternary ammonium(out) => ADP + H(+) + phosphate + quaternary ammonium(in)
REACT:R-RNO-420980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Rattus norvegicus)
GO:0047109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxyacid-ester dehydrogenase activity
GO:0047109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxyacid ester dehydrogenase activity
GO:0047109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity
GO:0047109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo ester (S)-reductase activity
RHEA:33378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + H(+) + NADPH <=> a 1-acyl-sn-glycero-3-phosphate + NADP(+)
RHEA:35365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentadecanoyl-CoA + NADP(+) => (2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH
GO:0015374	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neutral, cationic amino acid:sodium:chloride symporter activity
GO:0015374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral, basic amino acid:sodium:chloride symporter activity
RHEA:18016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-ethyl-L-glutamine <=> ethylamine + L-glutamate
REACT:R-MMU-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Mus musculus)
REACT:R-MMU-140806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINC1 binds SERPINC1 activators (Mus musculus)
REACT:R-MMU-8941701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Mus musculus)
REACT:R-CFA-8948222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)
REACT:R-RNO-419351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF receptor binds platelet activating factor (Rattus norvegicus)
REACT:R-XTR-5693615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Xenopus tropicalis)
REACT:R-BTA-5228508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates PML with SUMO1 (Bos taurus)
RHEA:37928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
REACT:R-XTR-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Xenopus tropicalis)
REACT:R-HSA-9021944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds RBFOX1 gene promoter (Homo sapiens)
REACT:R-CFA-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Canis familiaris)
RHEA:33583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase"
RHEA:33583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate = 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
RHEA:33583	skos:prefLabel	"UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase"
RHEA:31698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
REACT:R-HSA-8953418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)
REACT:R-RNO-6784734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds LDLR (Rattus norvegicus)
REACT:R-SCE-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Saccharomyces cerevisiae)
RHEA:46098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 CO2 + 4 CoA + dihydropinosylvin => 3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA
RHEA:28851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose(in) + Na(+)(in) = melibiose(out) + Na(+)(out)
REACT:R-SSC-5688294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT5 deacetylates Cytochrome C (Sus scrofa)
RHEA:22290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose => an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O
REACT:R-XTR-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)
REACT:R-SSC-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Sus scrofa)
RHEA:37797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 NADP(+) => 2 H(+) + 2 NADPH + O2
RHEA:52313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + thromboxane B2 => 11-dehydro-thromboxane B2 + H(+) + NADH
REACT:R-SSC-9690439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds LTC4,LTD4,LTE4 (Sus scrofa)
REACT:R-BTA-8987179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Bos taurus)
RHEA:65023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + succinyl-CoA <=> CoA + H(+) + N(2)-succinyl-L-ornithine
RHEA:50597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[histone H4] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]
REACT:R-DME-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Drosophila melanogaster)
RHEA:57792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dinitrotoluene + NADH + O2 = 4-methyl-6-nitrocatechol + NAD(+) + nitrite
REACT:R-BTA-1679589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal full-length TLR9 (Bos taurus)
REACT:R-HSA-9668148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F8 variant is not sulfonated at Y1699 (Homo sapiens)
REACT:R-MMU-8956568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the core TAL1 complex (Mus musculus)
GO:0042962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acridine efflux pump activity
GO:0042962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acridine:hydrogen antiporter activity
GO:0042962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acridine:proton antiporter activity
RHEA:45170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine => 2 (E)-sinapoyl-CoA + spermidine
REACT:R-PFA-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Plasmodium falciparum)
REACT:R-DRE-6814549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA transcript initiation, Integrator binding, LEC binding (Danio rerio)
RHEA:17864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone <=> 20-hydroxy-3-oxopregn-4-en-21-al
REACT:R-CEL-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Caenorhabditis elegans)
RHEA:39178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyeicosanoyl-CoA <=> (2E)-eicosenoyl-CoA + H2O
RHEA:46580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 = 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glucosamine 6-phosphate + H(+) => ATP + D-glucosamine
REACT:R-CEL-9663511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds GSTA1, FABP1 (Caenorhabditis elegans)
RHEA:44446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacylglycerol + H2O
RHEA:30112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-enterobactin + H(+) + 3 H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-MMU-1433501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other adapter proteins with p-KIT (Mus musculus)
REACT:R-RNO-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
RHEA:58621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-decanoyl-(2S)-hydroxyglycine => decanamide + glyoxylate
GO:0033850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity
GO:0033850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Z-farnesyl diphosphate synthase activity
GO:0033850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(Z)-farnesyl diphosphate synthase activity
REACT:R-DRE-1676162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Danio rerio)
REACT:R-HSA-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Homo sapiens)
REACT:R-XTR-5159245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)
RHEA:65050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetoxybenzaldehyde + H(+) + NADH => 4-acetoxybenzyl alcohol + NAD(+)
RHEA:68519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> beta-acoradiene + diphosphate
REACT:R-DRE-5607023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IXa associates with cell membrane (Danio rerio)
RHEA:31496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP
REACT:R-CFA-9749986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Canis familiaris)
REACT:R-RNO-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Rattus norvegicus)
REACT:R-HSA-178218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)
RHEA:40333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP
RHEA:41559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate
RHEA:30254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinol + n H(+)(in) + O2 <=> 2 a ubiquinone + n H(+)(out) + 2 H2O
RHEA:31563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leukotriene-C4 hydrolase"
RHEA:31563	skos:prefLabel	"leukotriene-C4 hydrolase"
RHEA:31563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene C4 = L-glutamate + leukotriene D4
RHEA:31563	skos:altLabel	"gamma-glutamyl leukotrienase"
REACT:R-DME-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)
REACT:R-PFA-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Plasmodium falciparum)
EC:2.4.1.301	skos:prefLabel	"2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase"
EC:2.4.1.301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase"
REACT:R-DRE-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Danio rerio)
RHEA:12002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADPH => formate + NADP(+)
REACT:R-RNO-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Rattus norvegicus)
REACT:R-CFA-388863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Canis familiaris)
RHEA:57618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase] => dihydro-ML-236C-[compactin nonaketide synthase] + H2O
REACT:R-BTA-8854759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D14 binds RAB11 and ULK1 (Bos taurus)
REACT:R-HSA-8865237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD6 methylates RELA in the NFkB complex (Homo sapiens)
REACT:R-XTR-2028294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Xenopus tropicalis)
REACT:R-HSA-937075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)
GO:0047251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-thiohydroximate glucosyltransferase activity
GO:0047251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiohydroximate glucosyltransferase activity
GO:0047251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiohydroximate S-glucosyltransferase activity
GO:0047251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiohydroximate beta-D-glucosyltransferase activity
GO:0047251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-hydroxythioamide S-beta-glucosyltransferase activity
GO:0047251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG:thiohydroximate glucosyltransferase activity
GO:0047251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desulfoglucosinolate-uridine diphosphate glucosyltransferase activity
GO:0047251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity
GO:0047251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity
REACT:R-HSA-9613768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOX10, POU3F1 and POU3F2 bind EGR2 gene (Homo sapiens)
REACT:R-BTA-688137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 is K63 polyubiquitinated (Bos taurus)
REACT:R-HSA-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
REACT:R-MMU-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Mus musculus)
REACT:R-BTA-2022379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Bos taurus)
RHEA:61179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]
RHEA:14060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a glycerophospholipid <=> a monoacylglycerophospholipid + a triacyl-sn-glycerol
RHEA:63787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-GGA-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Gallus gallus)
REACT:R-MMU-5686657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC1:XPF cleaves flaps generated by SSA (Mus musculus)
REACT:R-HSA-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Homo sapiens)
RHEA:37274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-glutamine(out) <=> ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate
REACT:R-SCE-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Saccharomyces cerevisiae)
RHEA:58928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-7,2',4'-trihydroxyisoflavanol = (6aR,11aR)-3,9-dihydroxypterocarpan + H2O
REACT:R-HSA-8851900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1-2 bound to MET recruits GRB2:SOS1 (Homo sapiens)
REACT:R-MMU-1008200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 binds the beta globin locus control region (Mus musculus)
RHEA:43218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine
REACT:R-RNO-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Rattus norvegicus)
REACT:R-HSA-417842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 receptor can bind to LPA (Homo sapiens)
RHEA:71483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Met-enkephalin = L-phenylalanyl-L-methionine + L-tyrosylglycylglycine
GO:0016677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor
GO:0016677	skos:prefLabel	"With a nitrogenous group as acceptor"
GO:0016677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a nitrogenous group as acceptor"
GO:0016677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
REACT:R-HSA-1791060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SRPRB (SRP Receptor subunit beta) (Homo sapiens)
REACT:R-MMU-8877941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SMAD1 in the nucleus (Mus musculus)
REACT:R-CEL-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Caenorhabditis elegans)
GO:0008861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PFL
GO:0008861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:formate C-acetyltransferase activity
GO:0008861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate formate-lyase activity
GO:0008861	skos:prefLabel	"formate C-acetyltransferase"
GO:0008861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate formate:lyase activity
GO:0008861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic formate-lyase activity
GO:0008861	skos:altLabel	"pyruvate formate-lyase"
GO:0008861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate acetyltransferase activity
GO:0008861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate C-acetyltransferase activity
GO:0008861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + formate = CoA + pyruvate
GO:0008861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate C-acetyltransferase"
REACT:R-MMU-5654426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
RHEA:17765	skos:altLabel	"diphosphoglycerate mutase"
RHEA:17765	skos:altLabel	"diphosphoglyceromutase"
RHEA:17765	skos:altLabel	"BPGM"
RHEA:17765	skos:altLabel	"bisphosphoglycerate synthase"
RHEA:17765	skos:altLabel	"2,3-bisphosphoglycerate synthase"
RHEA:17765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bisphosphoglycerate mutase"
RHEA:17765	skos:altLabel	"2,3-diphosphoglycerate mutase"
RHEA:17765	skos:altLabel	"glycerate phosphomutase"
RHEA:17765	skos:altLabel	"2,3-bisphosphoglycerate mutase"
RHEA:17765	skos:prefLabel	"bisphosphoglycerate mutase"
RHEA:17765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)
REACT:R-CFA-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Canis familiaris)
REACT:R-HSA-4754187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Homo sapiens)
RHEA:38633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA
RHEA:65472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + ethanol = CoA + ethyl 2-methylbutanoate
RHEA:42698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + pyruvate + selnoneine thione => H2O + hercynylselenocysteine
RHEA:49262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose 6-phosphate(in) + L-histidyl-[protein] => D-galactose(out) + N(pros)-phospho-L-histidyl-[protein]
REACT:R-MMU-5159245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Mus musculus)
REACT:R-HSA-198983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NKG2D homodimer interacting with ligands (Homo sapiens)
RHEA:50347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH <=> 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)
REACT:R-RNO-112042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid binds MOR (Rattus norvegicus)
RHEA:56788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[corrinoid adenosyltransferase] + cob(II)alamin = cob(II)alamin-[corrinoid adenosyltransferase]
RHEA:20997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-aminomuconate + H2O => (3E)-2-oxohex-3-enedioate + NH4(+)
RHEA:21725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nitrile + 2 H2O => a carboxylate + NH4(+)
REACT:R-HSA-9035180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of EEPD1 regulated by NR1H2 or NR1H3 (Homo sapiens)
RHEA:37332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionyl-L-alanine => L-alanine + L-methionine
REACT:R-CFA-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Canis familiaris)
REACT:R-HSA-8848804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)
REACT:R-DME-201677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Drosophila melanogaster)
RHEA:68046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose
REACT:R-CFA-109514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Canis familiaris)
REACT:R-SCE-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Saccharomyces cerevisiae)
RHEA:16976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxypyridine + AH2 + O2 <=> 2,5-dihydroxypyridine + A + H2O
REACT:R-HSA-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)
REACT:R-BTA-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Bos taurus)
REACT:R-BTA-374173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR1 (Bos taurus)
RHEA:66701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate
REACT:R-SPO-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Schizosaccharomyces pombe)
REACT:R-HSA-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)
RHEA:32441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-9008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds ESR1:estrogen:TGFA gene (Bos taurus)
RHEA:70485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2
RHEA:14416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,3-diol + O2 <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)
REACT:R-HSA-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Homo sapiens)
REACT:R-SSC-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Sus scrofa)
RHEA:72164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) => chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)
REACT:R-HSA-8853762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET dimerizes (Homo sapiens)
GO:0070406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine binding
RHEA:41003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine
REACT:R-GGA-2473594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP15 (Gallus gallus)
REACT:R-CFA-1964501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Canis familiaris)
REACT:R-DDI-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Dictyostelium discoideum)
REACT:R-MMU-450551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 binds translation and heat shock proteins (Mus musculus)
REACT:R-RNO-9701524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated downstream of active ALK (Rattus norvegicus)
RHEA:67345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 7-O-beta-D-glucoside + malonyl-CoA => CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)
RHEA:67032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Gallus gallus)
REACT:R-MMU-4086216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII binds integrin alpha2beta1 (Mus musculus)
REACT:R-SSC-8940561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP7 cleaves OPTC (Sus scrofa)
RHEA:15885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactaldehyde reductase (NADPH)"
RHEA:15885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH
RHEA:15885	skos:prefLabel	"lactaldehyde reductase (NADPH)"
RHEA:61948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate
RHEA:12719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP
RHEA:62899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)
REACT:R-GGA-9008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds ESR1:estrogen:TGFA gene (Gallus gallus)
RHEA:37014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:68505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => (Z)-beta-farnesene + diphosphate
REACT:R-DDI-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Dictyostelium discoideum)
RHEA:41054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA
REACT:R-HSA-6809140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL35 binds IL-12RB2:IL6ST receptor (Homo sapiens)
REACT:R-CFA-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)
REACT:R-MMU-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Mus musculus)
REACT:R-XTR-888614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO2 dioxygenates L-Trp to NFK (Xenopus tropicalis)
RHEA:44607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)
REACT:R-CEL-2993447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6x(PCCA:PCCB) (Caenorhabditis elegans)
GO:1902118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcifediol binding
GO:1902118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol binding
GO:1902118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25OHD3 binding
GO:1902118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholecalciferol binding
GO:1902118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D3 binding
GO:1902118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxyvitamin D3 binding
RHEA:48121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 + H2O => ganglioside GM3 + N-acetylneuraminate
RHEA:18034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:70656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + sarcosine(in) => H(+)(out) + sarcosine(out)
RHEA:66595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA <=> a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)
RHEA:43283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate
REACT:R-HSA-427527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC dimethylates histone H3 at lysine-9 (Homo sapiens)
RHEA:15457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + H(+) + NADH
RHEA:15457	skos:prefLabel	"cis-1,2-dihydrobenzene-1,2-diol dehydrogenase"
RHEA:15457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydrobenzene-1,2-diol + NAD(+) = catechol + H(+) + NADH
RHEA:15457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-1,2-dihydrobenzene-1,2-diol dehydrogenase"
RHEA:15457	skos:altLabel	"cis-benzene glycol dehydrogenase"
RHEA:46167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H(+) + NADPH <=> a quinol + NADP(+)
RHEA:30032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-muconolactone => cis,cis-muconate + H(+)
REACT:R-BTA-9707504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 oxidises ferrohemoglobin to MetHb (Bos taurus)
RHEA:51006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+) => a primary alcohol + 2 Fe(III)-[cytochrome cL]
RHEA:44110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + heptanoate + NADH => H2O + heptanal + NAD(+)
REACT:R-CFA-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)
RHEA:69580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + inosine = 2'-deoxyguanosine + IMP
RHEA:45790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA => (9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol
RHEA:34767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + H2O = (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)
REACT:R-XTR-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Xenopus tropicalis)
RHEA:16465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + 2 Fe(III)-[cytochrome c553] = 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate
RHEA:16465	skos:prefLabel	"D-lactate dehydrogenase (cytochrome c-553)"
RHEA:16465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-lactate dehydrogenase (cytochrome c-553)"
REACT:R-BTA-265429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Bos taurus)
REACT:R-CFA-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Canis familiaris)
RHEA:44736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-5-phosphooxypentane-2,4-dione thiolase"
RHEA:44736	skos:altLabel	"3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase"
RHEA:44736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4-dioxopentyl phosphate + CoA
RHEA:44736	skos:prefLabel	"3-hydroxy-5-phosphooxypentane-2,4-dione thiolase"
REACT:R-HSA-1454689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 Binds p-S237-TBC1D1 (Homo sapiens)
REACT:R-MMU-5672304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Mus musculus)
REACT:R-DDI-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Dictyostelium discoideum)
REACT:R-HSA-419490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATP to P2X receptors (Homo sapiens)
REACT:R-BTA-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Bos taurus)
REACT:R-XTR-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Xenopus tropicalis)
RHEA:62472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine
REACT:R-GGA-6801195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3 binds BNIP3L (Gallus gallus)
REACT:R-BTA-5661120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Bos taurus)
REACT:R-DDI-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Dictyostelium discoideum)
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine 5'-monophosphosialic acid synthetase activity
GO:0008781	skos:altLabel	"CMP-sialate synthase"
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphosialate pyrophosphorylase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylneuraminate cytidyltransferase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylneuraminate cytidylyltransferase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphosialate synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-sialic acid synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminic acid synthase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate
GO:0008781	skos:altLabel	"CMP-sialate pyrophosphorylase"
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:N-acylneuraminate cytidylyltransferase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphoacetylneuraminic synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-NeuAc synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate synthase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-sialic synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminic acid synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphosialic acid synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate synthetase activity
GO:0008781	skos:altLabel	"CMP-sialate diphosphorylase"
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-sialate diphosphorylase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-NANA synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-Neu5Ac synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylneuraminate cytidylyltransferase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-sialate pyrophosphorylase activity
GO:0008781	skos:altLabel	"CMP-N-acetylneuraminic acid synthetase"
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-sialate synthase activity
GO:0008781	skos:altLabel	"CMP-sialic acid synthetase"
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acylneuraminate cytidylyltransferase"
GO:0008781	skos:altLabel	"CMP-NeuNAc synthetase"
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-sialate synthetase activity
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity
GO:0008781	skos:prefLabel	"N-acylneuraminate cytidylyltransferase"
GO:0008781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-NeuNAc synthetase activity
REACT:R-SSC-2028629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Sus scrofa)
RHEA:18313	skos:altLabel	"mandelonitrile benzaldehyde-lyase"
RHEA:18313	skos:altLabel	"hydroxynitrile lyase"
RHEA:18313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile = benzaldehyde + hydrogen cyanide
RHEA:18313	skos:prefLabel	"(R)-mandelonitrile lyase"
RHEA:18313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-mandelonitrile lyase"
RHEA:18313	skos:altLabel	"D-oxynitrilase"
RHEA:18313	skos:altLabel	"(R)-oxynitrilase"
REACT:R-GGA-9624272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMPs cleave HB-EGF (Gallus gallus)
REACT:R-BTA-2127257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Bos taurus)
RHEA:65095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] <=> aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:43246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
REACT:R-XTR-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Xenopus tropicalis)
REACT:R-BTA-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Bos taurus)
REACT:R-DDI-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Dictyostelium discoideum)
REACT:R-XTR-9012036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)
REACT:R-DME-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Drosophila melanogaster)
REACT:R-RNO-8863494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASICs bind STOML3, (STOM) (Rattus norvegicus)
GO:0140393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norsolorinic acid ketoreductase activity
REACT:R-XTR-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Xenopus tropicalis)
GO:0047091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine 6-monooxygenase (NADPH) activity
GO:0047091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine 6-monooxygenase activity
GO:0047091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine N6-hydroxylase activity
GO:0047091	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)
GO:0047091	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine N(6)-hydroxylase activity
REACT:R-SSC-4088264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Sus scrofa)
GO:0000064	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-ornithine transporter activity
GO:0000064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine transmembrane transporter activity
GO:0000064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Homo sapiens)
GO:0000064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine/arginine/lysine/ornithine porter activity
REACT:R-SSC-5195402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LPIN (Sus scrofa)
RHEA:50720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + methanesulfinate + O2 = FMN + H(+) + H2O + methanesulfonate
RHEA:51402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octadecanoyl-serotonin => octadecanoyl-CoA + serotonin
GO:0036401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PK receptor activity
GO:0036401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrokinin receptor activity
REACT:R-DME-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Drosophila melanogaster)
REACT:R-XTR-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Xenopus tropicalis)
REACT:R-HSA-9679839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 binds ponatinib (Homo sapiens)
REACT:R-DME-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Drosophila melanogaster)
REACT:R-SPO-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Schizosaccharomyces pombe)
REACT:R-XTR-8986994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Xenopus tropicalis)
REACT:R-CFA-5683967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)
REACT:R-HSA-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Homo sapiens)
REACT:R-CFA-6807866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the ERGIC (Canis familiaris)
REACT:R-RNO-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Rattus norvegicus)
REACT:R-SSC-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Sus scrofa)
REACT:R-GGA-380949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK is dephosphorylated (Gallus gallus)
RHEA:11103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyhexan-3-one <=> 2 propanal
REACT:R-SSC-997314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of JAK1 by SHP1 (Sus scrofa)
RHEA:41142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)
RHEA:55503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0004103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline kinase activity
GO:0004103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline-ethanolamine kinase activity
GO:0004103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline phosphokinase activity
GO:0004103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline kinase (phosphorylating)
GO:0004103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:choline phosphotransferase activity
REACT:R-SSC-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Sus scrofa)
REACT:R-HSA-5693615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Homo sapiens)
RHEA:32282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + 2 H(+) + 2 H2O <=> (S)-ureidoglycolate + CO2 + 2 NH4(+)
REACT:R-CEL-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Caenorhabditis elegans)
RHEA:57270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP
RHEA:57249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glycolate + H(+)
REACT:R-DDI-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Dictyostelium discoideum)
RHEA:56019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)
REACT:R-HSA-1791075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DNAJB11 (Homo sapiens)
REACT:R-CEL-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)
REACT:R-SSC-5685953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates RBBP8 (Sus scrofa)
REACT:R-RNO-5654637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)
REACT:R-DME-8856630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIDEA:CIDEC binds lipid droplets (Drosophila melanogaster)
REACT:R-XTR-74207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Xenopus tropicalis)
RHEA:24046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => 3,4-dihydroxybenzoate + O2
RHEA:19571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine
RHEA:59797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
RHEA:52381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)
REACT:R-SCE-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Saccharomyces cerevisiae)
RHEA:30704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + salicylate => CO2 + phenol
REACT:R-HSA-265429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Homo sapiens)
REACT:R-HSA-9703440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 fusions:GRB2 bind GAB2 (Homo sapiens)
RHEA:14423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine => H2O + N(2)-benzoyl-D-arginine-4-nitroanilide
RHEA:36174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + a long chain fatty alcohol <=> 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)
REACT:R-HSA-9618750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKII phosphorylates AMPA receptor (Homo sapiens)
REACT:R-MMU-2090043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(7) (Mus musculus)
RHEA:22737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formimidoyltetrahydrofolate + 2 H(+) => 5,10-methenyltetrahydrofolate + NH4(+)
REACT:R-DDI-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Dictyostelium discoideum)
GO:0102515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity
RHEA:17214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-mannosamine
REACT:R-SSC-934604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)
REACT:R-XTR-9669893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type I TKIs (Xenopus tropicalis)
RHEA:40387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
RHEA:50991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin F2alpha(out) <=> prostaglandin F2alpha(in)
REACT:R-RNO-168400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iE-DAP elicits a NOD1 response (Rattus norvegicus)
REACT:R-BTA-9009371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of AP1 transcriptional activator complexes to CCND1 promoter (Bos taurus)
RHEA:35296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-molybdopterin + H(+) + tungstate => AMP + H2O + W-molybdopterin cofactor
REACT:R-RNO-77594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Rattus norvegicus)
REACT:R-DRE-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Danio rerio)
REACT:R-MMU-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Mus musculus)
RHEA:47530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
RHEA:14647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-homoserine + S-methyl-5'-thioadenosine => H2O + S-adenosyl-L-methionine
RHEA:29083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + ubiquinone-8 = oxaloacetate + ubiquinol-8
REACT:R-DME-8849900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs1-3 bind each other in cis interactions (Drosophila melanogaster)
RHEA:33084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehypoxanthine futalosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine
RHEA:32566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> alpha-terpinene + diphosphate
REACT:R-MMU-190520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Golgi  transport vesicles with microtubules (Mus musculus)
REACT:R-MMU-5692755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates MAPK6 (Mus musculus)
REACT:R-BTA-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Bos taurus)
REACT:R-CEL-2750187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Caenorhabditis elegans)
EC:3.1.3.56	skos:altLabel	"InsP3/Ins(1,3,4,5)P4 5-phosphatase"
EC:3.1.3.56	skos:altLabel	"5PTase"
EC:3.1.3.56	skos:altLabel	"D-myo-inositol 1,4,5-trisphosphate 5-phosphatase"
EC:3.1.3.56	skos:altLabel	"inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase"
EC:3.1.3.56	skos:altLabel	"inositol polyphosphate-5-phosphatase"
EC:3.1.3.56	skos:altLabel	"inositol-1,4,5-trisphosphate 5-phosphatase"
EC:3.1.3.56	skos:altLabel	"D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase"
EC:3.1.3.56	skos:altLabel	"inositol 1,4,5-trisphosphate phosphatase"
EC:3.1.3.56	skos:altLabel	"myo-inositol-1,4,5-trisphosphate 5-phosphatase"
EC:3.1.3.56	skos:altLabel	"inositol trisphosphate phosphomonoesterase"
EC:3.1.3.56	skos:altLabel	"D-myo-inositol 1,4,5-triphosphate 5-phosphatase"
EC:3.1.3.56	skos:altLabel	"Ins(1,4,5)P3 5-phosphatase"
EC:3.1.3.56	skos:altLabel	"inosine triphosphatase"
EC:3.1.3.56	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-polyphosphate 5-phosphatase"
EC:3.1.3.56	skos:altLabel	"type I inositol-polyphosphate phosphatase"
EC:3.1.3.56	skos:altLabel	"L-myo-inositol 1,4,5-trisphosphate-monoesterase"
EC:3.1.3.56	skos:prefLabel	"inositol-polyphosphate 5-phosphatase"
EC:3.1.3.56	skos:altLabel	"inositol phosphate 5-phosphomonoesterase"
RHEA:55178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + butanoyl-CoA + O2
REACT:R-SSC-873924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IFNGR1 by JAK kinases (Sus scrofa)
RHEA:45036	skos:altLabel	"HOX2"
RHEA:45036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxylamine oxidase"
RHEA:45036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Fe(III)-[cytochrome c] + hydroxylamine = 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide
RHEA:45036	skos:altLabel	"HOX"
RHEA:45036	skos:prefLabel	"hydroxylamine oxidase"
REACT:R-DRE-5607733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 binds CARD9 (Danio rerio)
RHEA:17063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + H2O + NADP(+) => H(+) + NADPH + O2 + phenol
REACT:R-DME-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Drosophila melanogaster)
REACT:R-BTA-1234183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Bos taurus)
RHEA:47630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylmalate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA
RHEA:70211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose = (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose
REACT:R-DME-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Drosophila melanogaster)
REACT:R-XTR-3234094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TFAP2C with SUMO1 (Xenopus tropicalis)
GO:0050562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine-tRNAPyl ligase activity
GO:0050562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine:tRNAPyl ligase (AMP-forming)
GO:0050562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine-tRNA(Pyl) ligase activity
REACT:R-HSA-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Homo sapiens)
REACT:R-MMU-216723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Mus musculus)
RHEA:53257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5695989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD11 dehydrogenates BH-CoA (Homo sapiens)
GO:0045550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl reductase activity
RHEA:31921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Canis familiaris)
RHEA:57207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + L-lysyl-[protein] <=> N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]
REACT:R-CFA-8857928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIHBP1 binds HSPG:LPL dimer (Canis familiaris)
RHEA:63566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apelin-12 + L-phenylalanine => apelin-13 + H2O
RHEA:12980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-phosphocreatine <=> creatine + phosphate
REACT:R-CFA-6803523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Canis familiaris)
REACT:R-XTR-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-HSA-211882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A7 can 6beta-hydroxylate testosterone (Homo sapiens)
GO:0015527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-phosphate:inorganic phosphate antiporter activity
RHEA:32972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine
REACT:R-HSA-4641260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)
REACT:R-CEL-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Caenorhabditis elegans)
RHEA:50119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + taurine <=> CoA + H(+) + N-eicosanoyl-taurine
RHEA:17971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
GO:0052617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-al oxidase activity
GO:0017151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEAD/H-box RNA helicase binding
REACT:R-HSA-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Homo sapiens)
REACT:R-SSC-2179274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD3 phosphorylated in the linker region (Sus scrofa)
REACT:R-XTR-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Xenopus tropicalis)
REACT:R-DRE-444705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R1/T1R3 dimer is the umami taste receptor (Danio rerio)
REACT:R-SSC-549129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations into hepatic cells (Sus scrofa)
REACT:R-HSA-8944522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-19a microRNA binds PTEN mRNA (Homo sapiens)
REACT:R-CFA-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Canis familiaris)
REACT:R-MMU-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Mus musculus)
REACT:R-HSA-446692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)
REACT:R-CFA-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Canis familiaris)
REACT:R-BTA-9021609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR-associated SRC autophosphorylates (Bos taurus)
REACT:R-RNO-2327695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Rattus norvegicus)
REACT:R-HSA-9034042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Homo sapiens)
REACT:R-SSC-72619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2:GTP is hydrolyzed, eIFs are released  (Sus scrofa)
GO:0050285	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aromatic choline esterase activity
GO:0050285	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sinapoylcholine sinapohydrolase activity
GO:0050285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapine esterase activity
RHEA:13323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + CO2 + NADH => (R)-3,3-dimethylmalate + NAD(+)
RHEA:15726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose => ascopyrone M + H2O
RHEA:21420	skos:prefLabel	"15-hydroxyprostaglandin-I dehydrogenase (NADP(+))"
RHEA:21420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"15-hydroxyprostaglandin-I dehydrogenase (NADP(+))"
RHEA:21420	skos:altLabel	"prostacyclin dehydrogenase"
RHEA:21420	skos:altLabel	"PG I2 dehydrogenase"
RHEA:21420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin I2 = 15-dehydro-prostaglandin I2 + H(+) + NADPH
REACT:R-RNO-170861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimeric TGF-beta-1 binds to the receptor (Rattus norvegicus)
GO:0061750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acid sphingomyelin phosphodiesterase activity
GO:0061750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acid sphingomyelinase
GO:0061750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid SMase
REACT:R-DME-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)
REACT:R-DRE-3214912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate MeK5-histone H3 (Danio rerio)
REACT:R-MMU-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Mus musculus)
GO:0061783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan muralytic activity
REACT:R-GGA-5668718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)
RHEA:68482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + pentadecanal => (2R)-2-hydroperoxyhexadecanoate + H(+)
REACT:R-CEL-8938887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML binds RUNX1 (Caenorhabditis elegans)
RHEA:28326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + wogonin 7-O-beta-D-glucuronate = D-glucuronate + H(+) + wogonin
REACT:R-DDI-199443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Dictyostelium discoideum)
REACT:R-DME-5634103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 dissociates from atRA:RAR:RXR (Drosophila melanogaster)
RHEA:18048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O <=> alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)
REACT:R-DME-977602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to MCP, CR1:C4b, C3b (Drosophila melanogaster)
REACT:R-BTA-5579018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1(868-1441) binds PAX3(1-319) (Bos taurus)
REACT:R-CFA-975903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Canis familiaris)
RHEA:45941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA
GO:0008410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-transferase activity
REACT:R-MMU-452108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Mus musculus)
REACT:R-CEL-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Caenorhabditis elegans)
REACT:R-DME-5654428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates SHC1 (Drosophila melanogaster)
REACT:R-XTR-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-CEL-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Caenorhabditis elegans)
RHEA:48514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + phosphinate(in) => ATP + H2O + phosphinate(out)
REACT:R-RNO-190681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in endoplasmic reticulum membrane (Rattus norvegicus)
REACT:R-CFA-2467665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds Beta amyloid fibril via GAG chains (Canis familiaris)
RHEA:57422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [cytochrome P450] => NADH + 2 oxidized [cytochrome P450]
REACT:R-CFA-3323013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
REACT:R-CFA-6805285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates TP53 (Canis familiaris)
RHEA:21638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP => (E)-4-coumarate + UDP-alpha-D-glucose
REACT:R-MMU-445797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLK (MLCK) Active Calmodulin Binding (Mus musculus)
RHEA:36404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cholesterol ester + H2O => a fatty acid + cholesterol + H(+)
RHEA:50214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
RHEA:16259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + alpha-D-glucose 1-phosphate => alpha,alpha-trehalose + phosphate
REACT:R-HSA-193996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11DCORST translocates from cytosol to mitochondrial matrix (Homo sapiens)
GO:0015203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyamine transmembrane transporter activity
GO:0015203	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amine/amide/polyamine channel activity
REACT:R-SCE-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)
RHEA:69133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine + H2O + O2 => 5-aminopentanal + H2O2 + NH4(+)
REACT:R-BTA-6814549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)
GO:0050660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavin adenine dinucleotide binding
GO:0050660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD or FADH2 binding
GO:0050660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavine-adenine dinucleotide binding
RHEA:63273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)
GO:0043758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate--CoA ligase (ADP-forming) activity
GO:0043758	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetate thiokinase activity
GO:0043758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl coenzyme A synthetase (adenosine diphosphate-forming)
GO:0043758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-CoA synthetase (ADP-forming) activity
GO:0043758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA synthetase (ADP-forming) activity
GO:0043758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate-CoA ligase (ADP-forming) activity
GO:0043758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetate:CoA ligase (ADP-forming)
EC:2.5.1.112	skos:altLabel	"adenylate isopentenyltransferase"
EC:2.5.1.112	skos:altLabel	"cytokinin synthase"
EC:2.5.1.112	skos:prefLabel	"adenylate dimethylallyltransferase (ADP/ATP-dependent)"
EC:2.5.1.112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylate dimethylallyltransferase (ADP/ATP-dependent)"
EC:2.5.1.112	skos:altLabel	"isopentenyltransferase"
REACT:R-HSA-9620891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO3 binds BTG1 gene promoter (Homo sapiens)
REACT:R-HSA-9757574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDL (Homo sapiens)
REACT:R-SCE-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Saccharomyces cerevisiae)
GO:0140303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramembrane lipid transporter activity
GO:0140303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flippase activity
GO:0140303	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	translocase activity
REACT:R-GGA-204779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang1 (Gallus gallus)
REACT:R-XTR-418091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB1 (Xenopus tropicalis)
GO:0005501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates the transport of atROL from ROS to RPE (Homo sapiens)
GO:0005501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinoid binding
REACT:R-SSC-204169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP dephosphorylates p-lipo-PDH (Sus scrofa)
GO:0051007	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene mutase (cyclizing)
GO:0051007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene = hop-22(29)-ene
GO:0051007	skos:prefLabel	"squalene--hopene cyclase"
GO:0051007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"squalene--hopene cyclase"
GO:0051007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene-hopene cyclase activity
GO:0051007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene:hopene cyclase activity
RHEA:14888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] <=> ADP-D-ribose + L-arginyl-[protein]
REACT:R-MMU-5634802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Mus musculus)
REACT:R-MMU-508282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK is a substrate for JAK1 (Mus musculus)
RHEA:68986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine
REACT:R-DME-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Drosophila melanogaster)
REACT:R-XTR-4093329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SDCBP (Xenopus tropicalis)
RHEA:12796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + ATP <=> 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP
RHEA:39859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol
REACT:R-HSA-9761836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p14ARF binds NFE2L2:CREBBP, EP300 (Homo sapiens)
REACT:R-MMU-2574845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA binds centrosome-associated AURKA (Mus musculus)
REACT:R-MMU-9684627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds CYSLTR1 antagonists (Mus musculus)
REACT:R-SSC-426489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC binds inexactly matching target RNAs (Sus scrofa)
REACT:R-HSA-158721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Homo sapiens)
REACT:R-HSA-9705320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
REACT:R-CFA-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Canis familiaris)
REACT:R-GGA-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Gallus gallus)
RHEA:55857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0034069	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	kanamycin acetyltransferase activity
GO:0034069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside N-acetyltransferase activity
RHEA:70346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + L-tyrosine + NADP(+) <=> 3-chloro-L-tyrosine + NADPH
RHEA:67792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleotidyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA
REACT:R-CFA-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Canis familiaris)
REACT:R-RNO-109291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Rattus norvegicus)
REACT:R-SPO-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Schizosaccharomyces pombe)
REACT:R-XTR-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Xenopus tropicalis)
RHEA:44998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-3-oxobutanoyl-(R)-carnitine => (R)-carnitine + acetoacetyl-CoA
GO:0005371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tricarboxylate secondary active transmembrane transporter activity
GO:0005371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tricarboxylate carrier activity
REACT:R-CFA-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Canis familiaris)
RHEA:32494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:11781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-DRE-77593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage and polyadenylation of Intronless Pre-mRNA (Danio rerio)
REACT:R-SSC-8931858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Sus scrofa)
REACT:R-DME-5686074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Drosophila melanogaster)
RHEA:32099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase"
RHEA:32099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + TRIBOA beta-D-glucoside = DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine
RHEA:32099	skos:altLabel	"OMT BX7"
RHEA:32099	skos:prefLabel	"2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase"
REACT:R-SSC-193789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Sus scrofa)
REACT:R-BTA-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Bos taurus)
REACT:R-CFA-158941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Canis familiaris)
REACT:R-SCE-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Saccharomyces cerevisiae)
EC:3.4.21.26	skos:prefLabel	"prolyl oligopeptidase"
EC:3.4.21.26	skos:altLabel	"prolyl endopeptidase"
EC:3.4.21.26	skos:altLabel	"post-proline endopeptidase"
EC:3.4.21.26	skos:altLabel	"post-proline cleaving enzyme"
EC:3.4.21.26	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prolyl oligopeptidase"
REACT:R-BTA-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Bos taurus)
REACT:R-HSA-3322140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MTR does not transfer CH3 group from MeCbl to HCYS (Homo sapiens)
RHEA:36470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanylglycine <=> glycine + L-alanine
REACT:R-XTR-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Xenopus tropicalis)
REACT:R-CFA-996727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST recruits the BHC complex (Canis familiaris)
REACT:R-SSC-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Sus scrofa)
RHEA:55006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => 1-hydroxylimonen-2-one + NADPH + O2
REACT:R-DRE-192054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Danio rerio)
REACT:R-CFA-5685985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Canis familiaris)
REACT:R-SPO-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Schizosaccharomyces pombe)
REACT:R-DDI-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Dictyostelium discoideum)
RHEA:23222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoyl-CoA + AMP + diphosphate => 4-chlorobenzoate + ATP + CoA
RHEA:18054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + paraoxon => 4-nitrophenol + diethylphosphate + 2 H(+)
REACT:R-SSC-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
REACT:R-XTR-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Xenopus tropicalis)
REACT:R-CFA-9678561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Canis familiaris)
REACT:R-MMU-6805022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 binds the heterodimer of MDM2 and MDM4 (Mus musculus)
REACT:R-MMU-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Mus musculus)
REACT:R-CEL-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Caenorhabditis elegans)
REACT:R-HSA-5682586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 and PIAS4 are recruited to DNA DSBs (Homo sapiens)
GO:0033723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetaldehyde dehydrogenase activity
GO:0033723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fluoroacetaldehyde:NAD+ oxidoreductase activity
REACT:R-DRE-9611851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 bind ADR,NAd (Danio rerio)
REACT:R-DRE-549129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations into hepatic cells (Danio rerio)
GO:0106266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O
GO:0106266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro THPH synthase activity
GO:0032145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinic semialdehyde dehydrogenase binding
GO:0032145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate-semialdehyde dehydrogenase binding
RHEA:62406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + pentadecanoate => (R)-2-hydroxyhexadecanoate + O2
REACT:R-BTA-8866551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR binds components of the ERAD machinery for ubiquitination and degradation (Bos taurus)
REACT:R-XTR-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Xenopus tropicalis)
RHEA:36977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + alpha-D-ribose 1,5-bisphosphate => AMP + phosphate
RHEA:64967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + 2 H2O <=> dUMP + 2 H(+) + 2 phosphate
REACT:R-HSA-6801637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates PLK2 expression (Homo sapiens)
RHEA:17014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphoenolpyruvate => 3-phosphonopyruvate
RHEA:45956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA(in) = (9Z)-octadecenoyl-CoA(out)
REACT:R-CEL-8848339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA5 hydrolyzes TAG (Caenorhabditis elegans)
REACT:R-GGA-9014294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the plasma membrane (Gallus gallus)
REACT:R-MMU-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-HSA-5632679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVC2:EVC binds p-SMO (Homo sapiens)
REACT:R-SSC-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Sus scrofa)
REACT:R-HSA-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Homo sapiens)
REACT:R-XTR-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Xenopus tropicalis)
REACT:R-SSC-6784399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Sus scrofa)
REACT:R-XTR-391378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follicle-stimulating hormone receptor can bind FSH (Xenopus tropicalis)
REACT:R-HSA-372519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcCho is hydrolyzed to Cho and acetate by ACHE (Homo sapiens)
REACT:R-RNO-2018682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Rattus norvegicus)
RHEA:63468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-octaprenol + ATP = ADP + all-trans-octaprenyl phosphate + H(+)
RHEA:24878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + L-sorbopyranose = 1-dehydro-L-sorbose + AH2
RHEA:24878	skos:prefLabel	"L-sorbose 1-dehydrogenase"
RHEA:24878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-sorbose 1-dehydrogenase"
RHEA:24878	skos:altLabel	"SDH"
GO:0004353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
GO:0004353	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamic dehydrogenase activity
GO:0004353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:NAD(P)+ oxidoreductase (deaminating)
GO:0004353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
GO:0004353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate dehydrogenase [NAD(P)+] activity
RHEA:36911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA
RHEA:10713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + O2 => 2-phenylacetamide + CO2 + H2O
RHEA:19552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + o-orsellinate depside <=> H(+) + 2 orsellinate
RHEA:44991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 2-methylpropanoyl-CoA <=> CoA + O-isobutanoyl-(R)-carnitine
REACT:R-DRE-9009541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds to TFF1 gene promoter (Danio rerio)
REACT:R-SSC-5618093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP90 (Sus scrofa)
RHEA:41536	skos:prefLabel	"2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase"
RHEA:41536	skos:altLabel	"neocarzinostatin O-methyltransferase"
RHEA:41536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine
RHEA:41536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase"
GO:0061602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdenum cofactor cytidylyltransferase activity
REACT:R-DDI-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Dictyostelium discoideum)
GO:0034878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisonicotinate dehydrogenase activity
RHEA:18718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine
REACT:R-MMU-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Mus musculus)
RHEA:49581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate => cyclic pyranopterin phosphate + diphosphate
RHEA:43238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycerol + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O
RHEA:64401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-amino acid tripeptide(out) + H(+)(out) => an L-amino acid tripeptide(in) + H(+)(in)
REACT:R-RNO-5669240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLNA binds PAK1 (Rattus norvegicus)
RHEA:55902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2
RHEA:13735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alk-2-enal + H(+) + NADH => an n-alkanal + NAD(+)
REACT:R-RNO-1362465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GHR (Rattus norvegicus)
REACT:R-CFA-3215310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)
REACT:R-CFA-8944216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XV (Canis familiaris)
REACT:R-DRE-444654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled bile acid receptor binds lithocholic acid (Danio rerio)
REACT:R-DRE-8987043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22RA1 binds JAK1 (Danio rerio)
RHEA:31996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => 7-epi-sesquithujene + diphosphate
RHEA:60188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate
RHEA:60188	skos:prefLabel	"[histone H3]-dimethyl-L-lysine(9) demethylase"
RHEA:60188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-dimethyl-L-lysine(9) demethylase"
REACT:R-BTA-3371554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 acetylation at Lys80 (Bos taurus)
REACT:R-DME-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Drosophila melanogaster)
REACT:R-HSA-2671885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers:H+ transport extracellular Na+ to cytosol (Homo sapiens)
RHEA:30024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate
REACT:R-CFA-6789072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP1 binds bacterial peptidoglycan (Canis familiaris)
REACT:R-DRE-212642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamine transport into neurons (Danio rerio)
REACT:R-DRE-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Danio rerio)
REACT:R-CFA-917811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3-like proteins reduce Fe3+ to Fe2+ (Canis familiaris)
GO:1901359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tungstate binding
REACT:R-CFA-9750226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 binds IKBKB and CHUK (Canis familiaris)
REACT:R-HSA-965067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THTPA:Mg2+ hydrolyzes ThTP to TDP (Homo sapiens)
REACT:R-BTA-6807008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates MET (Bos taurus)
RHEA:41562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O => (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2
REACT:R-BTA-5225649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP7 binds histone H3 (Bos taurus)
RHEA:23042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-ethylmalate + CoA + H(+) => 2-oxobutanoate + acetyl-CoA + H2O
RHEA:67742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aceneuramate => N-acetyl-beta-neuraminate
REACT:R-BTA-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Bos taurus)
GO:0070679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	InsP3 binding
GO:0070679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,4,5 trisphosphate binding
GO:0070679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3 binding
REACT:R-DME-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Drosophila melanogaster)
RHEA:34223	skos:prefLabel	"6-hydroxypseudooxynicotine dehydrogenase"
RHEA:34223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-hydroxypseudooxynicotine dehydrogenase"
RHEA:34223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxypseudooxynicotine + A + H2O = 2,6-dihydroxypseudooxynicotine + AH2
REACT:R-CFA-73931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Canis familiaris)
REACT:R-XTR-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Xenopus tropicalis)
RHEA:43566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine
RHEA:50583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]
RHEA:36702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP <=> 8-desmethylnovobiocic acid + AMP + diphosphate
RHEA:12775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dihydroclavaminate + H2O + succinate => 2-oxoglutarate + O2 + proclavaminate
REACT:R-DME-446372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  PARVA with TESK1 (Drosophila melanogaster)
RHEA:29608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + nitrous oxide => H(+) + NADH + 2 nitric oxide
REACT:R-DRE-139970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO3:FAD N-oxidises TMA to TMAO (Danio rerio)
RHEA:63041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lovastatin => H(+) + lovastatin carboxylate
RHEA:51340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate
GO:0005115	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Ror binding
GO:0005115	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	receptor tyrosine kinase-like orphan receptor ligand
GO:0005115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ror ligand
GO:0005115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor tyrosine kinase-like orphan receptor binding
REACT:R-MMU-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Mus musculus)
REACT:R-RNO-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Rattus norvegicus)
REACT:R-CFA-4086216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII binds integrin alpha2beta1 (Canis familiaris)
RHEA:41247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate
RHEA:38312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carminomycin + S-adenosyl-L-methionine => daunorubicin + H(+) + S-adenosyl-L-homocysteine
RHEA:23272	skos:altLabel	"UDP-glucose-zeatin 7-glucosyltransferase"
RHEA:23272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-alkylaminopurine + UDP-alpha-D-glucose = an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP
RHEA:23272	skos:altLabel	"uridine diphosphoglucose-zeatin 7-glucosyltransferase"
RHEA:23272	skos:prefLabel	"cytokinin 7-beta-glucosyltransferase"
RHEA:23272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytokinin 7-beta-glucosyltransferase"
RHEA:23272	skos:altLabel	"cytokinin 7-glucosyltransferase"
REACT:R-HSA-201712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin:TCF associates with BCL9 and PYGO (Homo sapiens)
REACT:R-BTA-205075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JNK phosphorylates BIM, BAD and other targets (Bos taurus)
REACT:R-SSC-9692539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds HRH1 inverse agonists (Sus scrofa)
REACT:R-HSA-5696021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPGK:Mg2+ phosphorylates Glc to G6P (Homo sapiens)
REACT:R-HSA-9034855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK3 (Homo sapiens)
REACT:R-BTA-9731613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)
REACT:R-HSA-909732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT2 (Homo sapiens)
REACT:R-XTR-389758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Xenopus tropicalis)
RHEA:14153	skos:prefLabel	"steroid N-acetylglucosaminyltransferase"
RHEA:14153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steroid N-acetylglucosaminyltransferase"
RHEA:14153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP
RHEA:14153	skos:altLabel	"sucrose-glucan glucosyltransferase"
REACT:R-HSA-110248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 3-methyladenine by MPG glycosylase  (Homo sapiens)
REACT:R-HSA-380008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)
REACT:R-GGA-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Gallus gallus)
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein phosphotransferase (cAMP-dependent) activity
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP-dependent protein kinase activity
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKA C
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKA
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein kinase A activity
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cAMP-dependent protein kinase activity
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP-dependent protein kinase, intrinsic catalyst activity
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5' cAMP-dependent protein kinase activity
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMPK
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic AMP-dependent protein kinase activity
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK22
GO:0004691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-cyclophosphate-dependent protein kinase activity
RHEA:14490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 2'-phosphate + H(+)
RHEA:59118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + H2O2 => [protein]-dithiol + O2
REACT:R-SSC-1564142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV degradation by MMP2,3,4,9,10,12 (Sus scrofa)
RHEA:64668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate
REACT:R-SSC-5433067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Sus scrofa)
GO:0050418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylamine (acceptor) reductase activity
GO:0050418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonia:acceptor oxidoreductase activity
GO:0050418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylamine reductase activity
GO:0050418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonia:(acceptor) oxidoreductase activity
REACT:R-XTR-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Xenopus tropicalis)
REACT:R-DRE-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Danio rerio)
REACT:R-HSA-977301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histidine is decarboxylated to histamine (Homo sapiens)
RHEA:57418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartyl-[protein] + NH4(+) => H2O + L-asparaginyl-[protein]
REACT:R-RNO-5362386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Hh (Rattus norvegicus)
REACT:R-DRE-8951595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Danio rerio)
RHEA:23587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydropteroate + ATP + L-glutamate <=> 7,8-dihydrofolate + ADP + H(+) + phosphate
REACT:R-CFA-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)
REACT:R-BTA-549241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-DRE-6799695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX5,6 reduce H2O2 to H2O (Danio rerio)
REACT:R-MMU-432164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Mus musculus)
REACT:R-DME-8982645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRKs bind ADRB2:Catecholamine (Drosophila melanogaster)
REACT:R-GGA-8849908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM4 binds flotillin-1 (Gallus gallus)
RHEA:41456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine
RHEA:26300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH <=> 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O
RHEA:30520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H(+) + phosphoenolpyruvate => diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine
REACT:R-HSA-1483002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to 1-acyl GO3P by GNPAT (Homo sapiens)
REACT:R-MMU-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Mus musculus)
REACT:R-BTA-1604368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of bound proMMP2 (Bos taurus)
RHEA:30974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,7',9,9'-tetra-cis-lycopene <=> all-trans-lycopene
REACT:R-CFA-1592436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP9 by MMPs (Canis familiaris)
REACT:R-RNO-5218838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXN binds p-6Y,S732-PTK2 (Rattus norvegicus)
REACT:R-DME-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Drosophila melanogaster)
REACT:R-MMU-193709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)
REACT:R-DRE-8848414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds CDKN1B (Danio rerio)
REACT:R-RNO-429016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 is phosphorylated by MAPKAP2 (Rattus norvegicus)
REACT:R-PFA-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Plasmodium falciparum)
REACT:R-HSA-8932355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades Ub-NFE2L2 (Homo sapiens)
REACT:R-DRE-2426566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and CLM7 (Danio rerio)
RHEA:71898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide
REACT:R-RNO-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
EC:3.5.1.69	skos:altLabel	"glycosphingolipid ceramide deacylase"
EC:3.5.1.69	skos:prefLabel	"glycosphingolipid deacylase"
EC:3.5.1.69	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycosphingolipid deacylase"
REACT:R-HSA-5610745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI2 (Homo sapiens)
REACT:R-SSC-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Sus scrofa)
RHEA:66331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine(out) <=> taurine(in)
RHEA:49589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythrulose 1-phosphate => D-erythrulose 4-phosphate
RHEA:54085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine => archaeosine(15) in tRNA + L-glutamate
REACT:R-MMU-170799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)
RHEA:25718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-168140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Rattus norvegicus)
RHEA:44284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 malonyl-CoA + octanoyl-CoA = 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA
RHEA:65143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + protoaustinoid A <=> A + berkeleyone A + H2O
RHEA:44363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxy-3,4-dioxopentyl phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate
RHEA:51242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2
REACT:R-DDI-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Dictyostelium discoideum)
REACT:R-HSA-9694304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 binds nsp12 (Homo sapiens)
REACT:R-DRE-2465934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL translocates from Muller cells to cone photoreceptor cells (Danio rerio)
REACT:R-GGA-433104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACT co-transports trivalent citrate and a sodium ion (Gallus gallus)
GO:0019809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine binding
RHEA:24803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-isoleucine
RHEA:15428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX
GO:0033763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline 3-hydroxylase activity
GO:0033763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
GO:0033763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P-3-H
REACT:R-SSC-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Sus scrofa)
REACT:R-HSA-2404139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSC cytosolic atROL translocates to extracellular region (Homo sapiens)
REACT:R-MMU-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Mus musculus)
REACT:R-CEL-4719447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO1 (Caenorhabditis elegans)
REACT:R-MMU-9014467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the ER membrane (Mus musculus)
REACT:R-MMU-3341277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
RHEA:61220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)
REACT:R-GGA-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Gallus gallus)
REACT:R-HSA-8944219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVI (Homo sapiens)
RHEA:14896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ornithine <=> (2R,4S)-2,4-diaminopentanoate
REACT:R-HSA-5654647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-CFA-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Canis familiaris)
RHEA:57831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + hypoxanthine
REACT:R-XTR-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Xenopus tropicalis)
REACT:R-BTA-844447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 senses MDP (Bos taurus)
REACT:R-GGA-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Gallus gallus)
REACT:R-SSC-6799246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates TP53 (Sus scrofa)
REACT:R-CEL-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
REACT:R-DME-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Drosophila melanogaster)
RHEA:39340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)
RHEA:61719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-galactofuranose(out) + H2O <=> ADP + D-galactofuranose(in) + H(+) + phosphate
RHEA:26212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine <=> acetaldehyde + glycine
RHEA:32924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-(1'-sn-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate
REACT:R-XTR-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Xenopus tropicalis)
RHEA:38218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + NAD(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADH
REACT:R-MMU-5591040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves Factor Va intermediate form for Factor Va (Mus musculus)
REACT:R-CFA-1067659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of hexameric IL-6 receptor (Canis familiaris)
REACT:R-CFA-159796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor IX to factor IX (Canis familiaris)
REACT:R-DME-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)
RHEA:24520	skos:altLabel	"aminoadipic semialdehyde synthase"
RHEA:24520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"saccharopine dehydrogenase (NAD(+), L-glutamate-forming)"
RHEA:24520	skos:altLabel	"saccharopin dehydrogenase"
RHEA:24520	skos:prefLabel	"saccharopine dehydrogenase (NAD(+), L-glutamate-forming)"
RHEA:24520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH
REACT:R-SSC-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Sus scrofa)
REACT:R-CFA-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Canis familiaris)
REACT:R-DME-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Drosophila melanogaster)
REACT:R-HSA-1433415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 (Homo sapiens)
REACT:R-XTR-5654600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
REACT:R-HSA-1655823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) (Homo sapiens)
RHEA:22091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP <=> AMP + guanosine 3'-diphosphate 5'-triphosphate
REACT:R-HSA-1562603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BfrB stores iron (Homo sapiens)
RHEA:20885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine + NAD(+) => 3-hydroxypyruvate + H(+) + NADH + NH4(+)
REACT:R-BTA-8876484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 transfers CHOL to NPC1 (Bos taurus)
GO:0004712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dual-specificity protein kinase
GO:0004712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dual-specificity kinase activity
GO:0004712	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein threonine/tyrosine kinase activity
GO:0004712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein serine/threonine/tyrosine kinase activity
REACT:R-DME-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Drosophila melanogaster)
GO:0050544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonic acid binding
GO:0050544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonate binding
RHEA:69391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + carbamoyl phosphate <=> allantoate + H(+) + phosphate
RHEA:19933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate
RHEA:19933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-1-phosphatase"
RHEA:19933	skos:prefLabel	"glucose-1-phosphatase"
GO:0004305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethanolamine kinase (phosphorylating)
GO:0004305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethanolamine phosphokinase activity
GO:0004305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:ethanolamine O-phosphotransferase activity
GO:0004305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine kinase activity
REACT:R-GGA-5099899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD4 (Gallus gallus)
RHEA:63973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydropyriculol => AH2 + pyriculol
RHEA:51948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Bos taurus)
RHEA:67868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)
RHEA:10998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine => 2-methylpropanal oxime + S-adenosyl-L-methionine
REACT:R-CFA-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Canis familiaris)
GO:0004952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine neurotransmitter receptor activity
REACT:R-RNO-352119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Rattus norvegicus)
REACT:R-CFA-166817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by C3 convertases (Canis familiaris)
RHEA:37562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Homo sapiens)
REACT:R-CFA-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Canis familiaris)
REACT:R-BTA-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Bos taurus)
REACT:R-SSC-8857577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 facilitates PTK6 autophosphorylation (Sus scrofa)
GO:0002951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene-C(4) hydrolase
REACT:R-HSA-9693478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A agonists (Homo sapiens)
RHEA:17068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + ATP <=> (R)-5-phosphomevalonate + ADP + H(+)
REACT:R-XTR-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Xenopus tropicalis)
REACT:R-CFA-1364044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR:JAK2 dimerizes (Canis familiaris)
REACT:R-CFA-8866405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)
RHEA:33710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonine <=> ADP + H(+) + O-phospho-L-threonine
RHEA:24923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine = 2-oxobutanoate + NH4(+)
REACT:R-DDI-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Dictyostelium discoideum)
RHEA:26301	skos:altLabel	"OHCU decarboxylase"
RHEA:26301	skos:prefLabel	"2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"
RHEA:26301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2
RHEA:26301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"
RHEA:22029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + taxa-4(20),11-dien-5alpha-ol => CoA + taxa-4(20),11-dien-5alpha-yl acetate
REACT:R-DDI-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Dictyostelium discoideum)
RHEA:51924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + menaquinone-9 = A + beta-dihydromenaquinone-9
RHEA:51924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"menaquinone-9beta-reductase"
RHEA:51924	skos:prefLabel	"menaquinone-9beta-reductase"
GO:0061665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0061665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO ligase activity
REACT:R-HSA-1791096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PPP2R5B (Homo sapiens)
REACT:R-GGA-5578783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Gallus gallus)
RHEA:39778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:68213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-DRE-5687284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMBT1 binds SFTPD 12mer, SFTPAs (Danio rerio)
REACT:R-XTR-73635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Xenopus tropicalis)
REACT:R-RNO-201712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin:TCF associates with BCL9 and PYGO (Rattus norvegicus)
REACT:R-CFA-201712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin:TCF associates with BCL9 and PYGO (Canis familiaris)
REACT:R-BTA-158313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XII -> factor XIIa (Bos taurus)
RHEA:71481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10) => H2O + neurotensin
REACT:R-DRE-8948775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKRN1 polyubiquitinates PTEN (Danio rerio)
REACT:R-MMU-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Mus musculus)
GO:0031992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	energy transducer activity
GO:0031992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	photon capture
GO:0031992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	light harvesting activity
REACT:R-GGA-9724745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds aprotinin (Gallus gallus)
RHEA:43132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine
REACT:R-HSA-5624133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3:GTP binds the UNC119B complex (Homo sapiens)
RHEA:57294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O
RHEA:38198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:45245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-octadienoyl-CoA => (2E,4E)-octadienoyl-CoA
REACT:R-CFA-3222020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUAK1 phosphorylates TP53 (Canis familiaris)
RHEA:41842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-[ACP] + NADP(+) => 3-oxooctanoyl-[ACP] + H(+) + NADPH
REACT:R-BTA-166041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of LPS onto TLR4 (Bos taurus)
RHEA:61145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin + UDP-beta-L-rhamnose => H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP
RHEA:59335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-hydroxy-gamma-carotene + A <=> 1'-hydroxytorulene + AH2
RHEA:20468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP
RHEA:25684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-9689680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNG inhibitors (Canis familiaris)
RHEA:40691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol = 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-haloacid dehalogenase activity
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-DEX activity
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	halocarboxylic acid halidohydrolase activity
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-haloacid dehalogenase activity
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-haloacid dehalogenase activity
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DL-2-haloacid dehalogenase activity
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-haloacid halidohydrolase activity
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-haloalkanoic acid dehalogenase activity
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-halocarboxylic acid dehalogenase II activity
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-haloalkanoid acid halidohydrolase activity
GO:0018784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-haloacid halidohydrolase activity
RHEA:43485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
REACT:R-MMU-5433067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Mus musculus)
RHEA:64408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out) = H(+)(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in)
RHEA:42547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(32) in tRNA <=> pseudouridine(32) in tRNA
REACT:R-DRE-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Danio rerio)
GO:0050540	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminomuconate aminohydrolase activity
GO:0050540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomuconate deaminase activity
GO:0050540	skos:prefLabel	"2-aminomuconate deaminase"
GO:0050540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-aminomuconate deaminase"
GO:0050540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH4(+)
REACT:R-MMU-9714361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC activates endoplasmic reticulum effectors (Mus musculus)
RHEA:13216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + succinate semialdehyde <=> 2 H(+) + NADPH + succinate
REACT:R-GGA-9724753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds anti-fibrinolytics (Gallus gallus)
RHEA:56802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide
RHEA:71025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(out) + L-phenylalanine(in) => L-leucine(in) + L-phenylalanine(out)
REACT:R-RNO-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Rattus norvegicus)
EC:1.14.99.-	skos:prefLabel	"Miscellaneous"
EC:1.14.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Miscellaneous"
REACT:R-SSC-8983870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Sus scrofa)
RHEA:22287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-carbamoylputrescine <=> CO2 + NH4(+) + putrescine
RHEA:10753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate
RHEA:37588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + L-glutamate
GO:0047217	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTF-S
GO:0047217	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase
GO:0047217	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	water-soluble-glucan synthase activity
GO:0047217	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity
GO:0047217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity
GO:0047217	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity
RHEA:33711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulfomuconolactone + H2O = 2 H(+) + maleylacetate + sulfite
RHEA:33711	skos:prefLabel	"4-sulfomuconolactone hydrolase"
RHEA:33711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-sulfomuconolactone hydrolase"
REACT:R-DRE-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
RHEA:32120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-valienol + validamine 7-phosphate => GDP + H(+) + validoxylamine A 7'-phosphate
RHEA:49561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate => (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate
RHEA:12839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphocholine => ATP + choline
GO:0102910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dirigent protein activity
REACT:R-DME-9018499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and EP300 are recruited to TFF3 promoter (Drosophila melanogaster)
RHEA:24006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-DDI-9025957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Dictyostelium discoideum)
RHEA:12198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + D-erythrose 4-phosphate + H2O => keto-D-fructose 6-phosphate + phosphate
REACT:R-RNO-8980228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Rattus norvegicus)
REACT:R-HSA-3965441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD recruits trimeric G-proteins (Homo sapiens)
REACT:R-MMU-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Mus musculus)
REACT:R-XTR-8848726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates BCAR1 (Xenopus tropicalis)
REACT:R-CEL-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Caenorhabditis elegans)
REACT:R-CEL-6799178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 1 binds HP subcomplex to form Intermediate 2 (Caenorhabditis elegans)
RHEA:69959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050175	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine dehydrogenase activity
GO:0050175	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine:NAD+ oxidoreductase (deaminating)
GO:0050175	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PheDH activity
GO:0050175	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PHD
GO:0050175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine dehydrogenase activity
REACT:R-HSA-9672175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGFR mutant dimers (Homo sapiens)
GO:0070905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine binding
GO:0070905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ser binding
RHEA:37855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:44961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + H(+) + NADPH => decanoyl-CoA + NADP(+)
RHEA:21406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorite => chloride + O2
RHEA:65166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexan-3-yl benzoate => benzoyl-CoA + hexan-3-ol
REACT:R-MMU-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Mus musculus)
RHEA:49535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O <=> ethylene glycol + H(+) + terephthalate
RHEA:51461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-glutamate => (9Z)-octadecenoate + L-glutamate
REACT:R-HSA-8938867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND3,(CCND1,CCND2) binds RUNX1 (Homo sapiens)
REACT:R-SSC-191763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP:Snurportin complex formation (Sus scrofa)
REACT:R-GGA-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)
REACT:R-SPO-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Schizosaccharomyces pombe)
RHEA:37822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:32700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => beta-sesquiphellandrene + diphosphate
REACT:R-SSC-983707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates at the activated BCR (Sus scrofa)
RHEA:36822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA
REACT:R-HSA-9703441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants (Homo sapiens)
REACT:R-RNO-202168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)
REACT:R-HSA-9651456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 variant does not bind factor XIIa (Homo sapiens)
GO:0050797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidylate synthase (FAD) activity
GO:0050797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin dependent thymidylate synthase activity
GO:0050797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ThyX activity
GO:0050797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity
GO:0050797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thy1 activity
GO:0050797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FDTS activity
RHEA:42354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-6-hydroxynicotine + AH2 => (R)-nicotine + A + H2O
REACT:R-RNO-8938076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD38 hydrolyses NAD+ to NAM and ADP-ribose (Rattus norvegicus)
RHEA:29228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + indole(in) => H(+)(out) + indole(out)
REACT:R-SCE-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Saccharomyces cerevisiae)
RHEA:20932	skos:prefLabel	"ketotetrose-phosphate aldolase"
RHEA:20932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ketotetrose-phosphate aldolase"
RHEA:20932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythrulose 1-phosphate = dihydroxyacetone phosphate + formaldehyde
RHEA:20932	skos:altLabel	"erythrulose-1-phosphate formaldehyde-lyase"
RHEA:20932	skos:altLabel	"erythrulose-1-phosphate synthetase"
RHEA:20932	skos:altLabel	"phosphoketotetrose aldolase"
RHEA:31690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate
RHEA:27382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + H2O => (2R)-2-phosphoglycerate + phosphate
RHEA:40721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+) => an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione
REACT:R-MMU-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Mus musculus)
RHEA:54648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase"
RHEA:54648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O
RHEA:54648	skos:prefLabel	"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase"
RHEA:24378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin
RHEA:56058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein 7-O-beta-D-glucoside + H(+) + UDP => genistein + UDP-alpha-D-glucose
REACT:R-CEL-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Caenorhabditis elegans)
REACT:R-DME-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Drosophila melanogaster)
REACT:R-XTR-975916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 5 by MGAT5 (Xenopus tropicalis)
RHEA:72416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Li(+)(in) + Na(+)(out) => Li(+)(out) + Na(+)(in)
RHEA:56186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NOR1 + H(+) + UDP => globoside Gb4Cer + UDP-alpha-D-galactose
RHEA:16012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + formate <=> ADP + formyl phosphate
RHEA:41254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate
REACT:R-HSA-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)
RHEA:48217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:14591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrysoeriol + H(+) + S-adenosyl-L-homocysteine => luteolin + S-adenosyl-L-methionine
REACT:R-CEL-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Caenorhabditis elegans)
REACT:R-HSA-3928595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ARP2/3 and G-actin (Homo sapiens)
REACT:R-DRE-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Danio rerio)
RHEA:15368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP
RHEA:29101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 4 H(+)(out) + NAD(+) => a menaquinone + 5 H(+)(in) + NADH
GO:0031869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostanoid IP receptor binding
GO:0031869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostacyclin receptor binding
GO:0031869	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	prostacyclin receptor ligand
RHEA:53686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2
REACT:R-SSC-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Sus scrofa)
REACT:R-BTA-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Bos taurus)
REACT:R-CFA-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Canis familiaris)
RHEA:33704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine
RHEA:58897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + ADP + phosphate
RHEA:40626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tritetradecanoylglycerol <=> 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate
GO:0047634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"agmatine N(4)-coumaroyltransferase"
GO:0047634	skos:altLabel	"p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase"
GO:0047634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + agmatine = CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide
GO:0047634	skos:prefLabel	"agmatine N(4)-coumaroyltransferase"
GO:0047634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	agmatine coumaroyltransferase activity
GO:0047634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine N4-coumaroyltransferase activity
GO:0047634	skos:altLabel	"agmatine coumaroyltransferase"
GO:0047634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity
GO:0047634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity
GO:0047634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity
REACT:R-RNO-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Rattus norvegicus)
RHEA:46842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:35084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetylchitobiose-6'-phosphate + H2O => acetate + N'-monoacetylchitobiose-6'-phosphate
REACT:R-DRE-9793679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates RIPK1 at K627 (Danio rerio)
RHEA:60129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate
RHEA:46361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-GGA-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Gallus gallus)
REACT:R-DRE-8871376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds PI3P (Danio rerio)
REACT:R-RNO-265301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticotropin cleavage from POMC (Rattus norvegicus)
RHEA:16941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylindoxyl + O2 = H2O + N-acetylisatin
RHEA:16941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylindoxyl oxidase"
RHEA:16941	skos:prefLabel	"acetylindoxyl oxidase"
RHEA:62086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + D-glucosamine 6-phosphate + H(+) => ADP + D-glucosamine
RHEA:50197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
REACT:R-MMU-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Mus musculus)
REACT:R-GGA-159796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor IX to factor IX (Gallus gallus)
REACT:R-RNO-8931653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Rattus norvegicus)
REACT:R-XTR-158860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates NHABP (Xenopus tropicalis)
GO:0140799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine:proton antiporter activity
RHEA:52245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 Mn(2+) + O2 => 2 H2O + 4 Mn(3+)
REACT:R-DRE-8851866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds RANBP10 (Danio rerio)
REACT:R-HSA-192746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of M1 to vRNP (Homo sapiens)
GO:0101020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oestrogen 16-alpha-hydroxylase activity
GO:0101020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrogen 16-alpha-hydroxylase activity
REACT:R-RNO-199093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXADR binds to AMICA1 (Rattus norvegicus)
GO:0047078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity
GO:0047078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinoline-3,4-diol 2,4-dioxygenase activity
GO:0047078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)
GO:0047078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-4(1H)-one, 2,4-dioxygenase activity
GO:0047078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity
GO:0047078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity
GO:0047078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity
REACT:R-RNO-204824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Ang4 (Rattus norvegicus)
REACT:R-XTR-198870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-RNO-392263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR2 (Rattus norvegicus)
REACT:R-RNO-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Rattus norvegicus)
RHEA:33590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate <=> CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
GO:0033910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucan 1,4-alpha-maltotetrahydrolase activity
GO:0033910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-maltotetraohydrolase activity
GO:0033910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltotetraose-forming amylase activity
GO:0033910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	G4-amylase activity
GO:0033910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-D-glucan maltotetraohydrolase activity
GO:0033910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan 1,4-alpha-maltotetraohydrolase activity
GO:0017045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenocorticotropin-releasing hormone
GO:0017045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin-releasing hormone activity
REACT:R-CFA-198613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates p21Cip1 and p27Kip1 (Canis familiaris)
REACT:R-DME-934559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is phosphorylated by phosphorylated MNK1 (Drosophila melanogaster)
REACT:R-DME-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Drosophila melanogaster)
REACT:R-CEL-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Caenorhabditis elegans)
REACT:R-DRE-390593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Danio rerio)
GO:0033796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur reductase activity
GO:0033796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphur reductase activity
GO:0033796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(donor):sulfur oxidoreductase activity
RHEA:34541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanetellurite + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tellurite
RHEA:15624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP
RHEA:47838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP => [5-(aminomethyl)-3-furyl]methyl phosphate + ATP
REACT:R-MMU-9706330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS6 (Mus musculus)
RHEA:40458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA <=> (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA
REACT:R-CEL-1602458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP10 (Caenorhabditis elegans)
REACT:R-GGA-5684052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates MDC1 (Gallus gallus)
RHEA:54550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate + phosphate => D-xylulose 1,5-bisphosphate + H2O
RHEA:68628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]
RHEA:68628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"C-phycoerythrin beta-cysteine-48/59 phycoerythrobilin lyase"
RHEA:68628	skos:prefLabel	"C-phycoerythrin beta-cysteine-48/59 phycoerythrobilin lyase"
REACT:R-DRE-175987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from AdoMet to PY (Danio rerio)
GO:0140935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2B conserved C-terminal lysine deubiquitinase activity
GO:0140935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone conserved C-terminal lysine deubiquitination
REACT:R-GGA-5662986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds copper (Gallus gallus)
RHEA:28843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline(in) + H(+)(in) = choline(out) + H(+)(out)
RHEA:34098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyspermidine + H(+) <=> CO2 + spermidine
RHEA:56052	skos:altLabel	"ManII"
RHEA:56052	skos:prefLabel	"mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase"
RHEA:56052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
RHEA:56052	skos:altLabel	"mannosidase II"
RHEA:56052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase"
RHEA:59207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)
REACT:R-RNO-8876472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 binds CHOL (Rattus norvegicus)
REACT:R-BTA-205008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF binds to p62 (Sequestosome) (Bos taurus)
REACT:R-GGA-9678561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Gallus gallus)
REACT:R-GGA-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Gallus gallus)
REACT:R-HSA-5663118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds PER2 gene (Homo sapiens)
RHEA:70365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-carboxybiuret + H(+) => cyanurate + H2O
REACT:R-XTR-428127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Xenopus tropicalis)
REACT:R-RNO-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Rattus norvegicus)
REACT:R-HSA-9733247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YBX1 binds COL1A2 gene promoter (Homo sapiens)
REACT:R-HSA-5649764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)
REACT:R-BTA-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)
REACT:R-GGA-114558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate Gq (Gallus gallus)
REACT:R-DRE-2168888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha1-Microglobulin binds heme (Danio rerio)
RHEA:50215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate
RHEA:56011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
GO:0102850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity
RHEA:43233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isatin => H(+) + isatinate
REACT:R-HSA-448421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 translocates from the ER lumen to the extracellular region (Homo sapiens)
RHEA:11207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
REACT:R-SPO-191983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)
REACT:R-RNO-8873834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 transports PC from ER membrane to lamellar body membrane (Rattus norvegicus)
REACT:R-DME-6786239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)
REACT:R-HSA-9693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds 5HT (Homo sapiens)
REACT:R-DDI-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Dictyostelium discoideum)
RHEA:16816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-kynurenine <=> anthranilate + H(+) + L-alanine
REACT:R-BTA-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Bos taurus)
REACT:R-CFA-9684627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds CYSLTR1 antagonists (Canis familiaris)
RHEA:49199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Sus scrofa)
REACT:R-RNO-2424485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-PLCG1 (Rattus norvegicus)
REACT:R-MMU-5687097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3 binds ETV4 (Mus musculus)
RHEA:71799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + H(+)(out) = Ca(2+)(out) + H(+)(in)
RHEA:63440	skos:prefLabel	"3-phospho-D-glycerate guanylyltransferase"
RHEA:63440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-phospho-D-glycerate guanylyltransferase"
RHEA:63440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate
REACT:R-SSC-432096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated integrin alphaIIb beta3 binds SHC1 (Sus scrofa)
REACT:R-DME-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Drosophila melanogaster)
REACT:R-SSC-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Sus scrofa)
RHEA:17180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + octanoyl-CoA <=> CoA + O-octanoyl-(R)-carnitine
RHEA:47827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + octadecanoyl-[ACP] <=> 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:30034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-muconolactone <=> cis,cis-muconate + H(+)
REACT:R-HSA-8948018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Homo sapiens)
RHEA:12375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O <=> 4-oxohex-2-enedioate + H(+)
REACT:R-MMU-416546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Mus musculus)
RHEA:21789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate
REACT:R-DRE-8941543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Danio rerio)
RHEA:22262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + triacetate => H2O + triacetate lactone
RHEA:33101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(1)-acetylspermine => acetyl-CoA + spermine
REACT:R-XTR-9690494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB translocates to the endosome membrane (Xenopus tropicalis)
REACT:R-CFA-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Canis familiaris)
RHEA:40289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + decanedioyl-CoA + diphosphate => ATP + CoA + decanedioate
RHEA:23079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoyl-CoA + chloride + NADP(+) <=> 2,4-dichlorobenzoyl-CoA + NADPH
GO:0043399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA A64-2'-O-ribosylphosphate transferase activity
GO:0043399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	initiator tRNA phosphoribosyl-transferase activity
RHEA:59970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-octanoyl-L-threonyl-[protein] => L-threonyl-[protein] + octanoyl-CoA
REACT:R-BTA-141040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Bos taurus)
REACT:R-GGA-9677585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Gallus gallus)
RHEA:37374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP
REACT:R-CFA-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Canis familiaris)
REACT:R-RNO-5654612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)
RHEA:40343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanedioyl-CoA + CoA = acetyl-CoA + tetradecanedioyl-CoA
RHEA:42285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
RHEA:68771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine
RHEA:33196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-XTR-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Xenopus tropicalis)
REACT:R-DME-2562526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates OPTN (Drosophila melanogaster)
REACT:R-DRE-201685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin is released from the destruction complex (Danio rerio)
RHEA:31441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-longipinene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-BTA-174238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Bos taurus)
RHEA:54515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peregrinol diphosphate <=> (13R)-9,13-epoxylabd-14-ene + diphosphate
REACT:R-CFA-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Canis familiaris)
REACT:R-SSC-9021601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Sus scrofa)
RHEA:16831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + H(+) + H2O2 => an aldehyde + H2O + O2
REACT:R-HSA-159194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)
RHEA:29379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + H2O = 2'-deoxyguanosine + phosphate
RHEA:32514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)
REACT:R-DDI-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)
REACT:R-SSC-5617815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binds RAB3IP (Sus scrofa)
RHEA:70809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-sulfo-D-erythrulose => 4-deoxy-4-sulfo-D-erythrose
REACT:R-RNO-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Rattus norvegicus)
REACT:R-BTA-198870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-DME-3000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BORA binds SCF-beta-TrCp1/2 (Drosophila melanogaster)
REACT:R-DRE-8983374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Danio rerio)
RHEA:14800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)
RHEA:22360	skos:prefLabel	"D-glutamate cyclase"
RHEA:22360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glutamate cyclase"
RHEA:22360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate = 5-oxo-D-proline + H2O
RHEA:23477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
REACT:R-MMU-5218819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
RHEA:33989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + neoabietadiene => (+)-copalyl diphosphate
GO:0034576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-isopropylacetanilide amidohydrolase activity
REACT:R-SSC-5653756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM25 binds monoUb:164-PCNA (Sus scrofa)
REACT:R-BTA-5617182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates PLN (Bos taurus)
REACT:R-HSA-5689861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of XPA and release of CAK  (Homo sapiens)
REACT:R-HSA-5246693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC is K63-polyubiquitinated (Homo sapiens)
REACT:R-MMU-2162227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses (HA)2 (Mus musculus)
RHEA:41647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate
REACT:R-RNO-429613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:23446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + pyruvate => (S)-lactate + NAD(+)
RHEA:10799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole + H(+) + NADPH + O2 <=> albendazole S-oxide + H2O + NADP(+)
GO:0032217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin transmembrane transporter activity
GO:0032217	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin transporter activity
REACT:R-MMU-174739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant + apoE => chylomicron remnant:apoE complex (Mus musculus)
RHEA:25752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
RHEA:56952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate
REACT:R-BTA-5654425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds SHC1 (Bos taurus)
RHEA:25836	skos:prefLabel	"3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)"
RHEA:25836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)"
RHEA:25836	skos:altLabel	"THcHDO hydrolase"
RHEA:25836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)
RHEA:29856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine => D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate
RHEA:68740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxocholesterol + H(+) + NADPH = 7alpha-hydroxycholesterol + NADP(+)
RHEA:61682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-cysteine
RHEA:18348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cis-3-alkyl-4-alkyloxetan-2-one <=> a cis-alkene + CO2
REACT:R-CFA-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)
RHEA:50845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
REACT:R-BTA-9610154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated MAP2Ks and MAPKs (Bos taurus)
REACT:R-XTR-1605717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Xenopus tropicalis)
GO:0044015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2BK12 acetyltransferase activity
GO:0044015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H2B-K12 specific)
GO:0044015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2B-K12 acetyltransferase activity
GO:0044015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H2B-K12 specific)
GO:0044015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H2B-K12 specific)
RHEA:56302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein] => [thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein]
REACT:R-SSC-9629918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 translocates to the nucleus (Sus scrofa)
REACT:R-DDI-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Dictyostelium discoideum)
REACT:R-SCE-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Saccharomyces cerevisiae)
RHEA:47808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:40423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Bos taurus)
REACT:R-MMU-444731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Mus musculus)
RHEA:55594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP] => 2 (3R)-hydroxydecanoyl-[ACP] + H2O
REACT:R-RNO-209903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline is converted to adrenaline (Rattus norvegicus)
REACT:R-XTR-5218820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src kinases phosphorylate VAV (Xenopus tropicalis)
RHEA:59085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)
REACT:R-DRE-112437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NELF complex  (Danio rerio)
REACT:R-HSA-6806408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the PMS2 gene (Homo sapiens)
REACT:R-SSC-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Sus scrofa)
RHEA:61772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside E + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP
REACT:R-DME-5610723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind SUFU (Drosophila melanogaster)
GO:1901641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITP binding
RHEA:66573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-naphthol + 3'-phosphoadenylyl sulfate => 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:22211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)
REACT:R-HSA-8875558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 binds CRK,CRKL (Homo sapiens)
RHEA:53338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NADP(+)
RHEA:29801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-allose(in) + H(+) + phosphate => ATP + D-allose(out) + H2O
RHEA:68375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine + pyruvate <=> 2-oxosuccinamate + L-alanine
GO:0102378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolmonoside glucosyltransferase activity
REACT:R-SSC-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Sus scrofa)
REACT:R-MMU-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Mus musculus)
REACT:R-BTA-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-SSC-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Sus scrofa)
RHEA:28468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine(out) => pyridoxamine(in)
REACT:R-HSA-177275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates DARPP-32 on Thr34 (Homo sapiens)
REACT:R-SSC-6807055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR7 reduces 7-dehydroCHOL to CHOL (Sus scrofa)
REACT:R-BTA-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Bos taurus)
RHEA:64795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NADP(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)
REACT:R-DRE-194017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 11DCORST to CORST (Danio rerio)
RHEA:26214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate + H2O => aphidicolan-16beta-ol + diphosphate
REACT:R-CEL-9688838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds STUB1 (Caenorhabditis elegans)
REACT:R-XTR-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
RHEA:18164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CoA
REACT:R-DDI-70859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Dictyostelium discoideum)
RHEA:14590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin + S-adenosyl-L-methionine => chrysoeriol + H(+) + S-adenosyl-L-homocysteine
RHEA:32872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + H2O => a carboxylate + glycerol + H(+)
REACT:R-RNO-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)
RHEA:70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-CFA-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)
REACT:R-HSA-176588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + PAPS => lithocholate sulfate + PAP (Homo sapiens)
REACT:R-BTA-947535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Bos taurus)
RHEA:31815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-(E)-beta-caryophyllene + diphosphate
RHEA:31815	skos:prefLabel	"(+)-beta-caryophyllene synthase"
RHEA:31815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-beta-caryophyllene synthase"
REACT:R-DME-9641109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Drosophila melanogaster)
REACT:R-RNO-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Rattus norvegicus)
REACT:R-BTA-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Bos taurus)
REACT:R-RNO-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Rattus norvegicus)
RHEA:46151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside + H(+) + triphosphate
REACT:R-CEL-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Caenorhabditis elegans)
RHEA:72239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + L-glutamate(in) = estrone 3-sulfate(in) + L-glutamate(out)
REACT:R-SSC-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Sus scrofa)
RHEA:68143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-hexanedione + 2 H(+) + 2 NADPH <=> (2R,5R)-hexanediol + 2 NADP(+)
GO:0070577	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetylated histone residue binding
GO:0070577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine-acetylated histone binding
RHEA:56136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peroxidase"
RHEA:56136	skos:altLabel	"lactoperoxidase"
RHEA:56136	skos:prefLabel	"peroxidase"
RHEA:56136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O
RHEA:49170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine
RHEA:25713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)
REACT:R-SSC-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Sus scrofa)
REACT:R-CEL-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
RHEA:57124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate = 2-hydroxy-5-oxoproline
REACT:R-RNO-1475032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Rattus norvegicus)
REACT:R-SSC-1861789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Sus scrofa)
REACT:R-DME-8876472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 binds CHOL (Drosophila melanogaster)
RHEA:43450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein]
REACT:R-CEL-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Caenorhabditis elegans)
REACT:R-DRE-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Danio rerio)
REACT:R-SSC-1297444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of cAMP to HCN channels (Sus scrofa)
RHEA:58986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylate + H(+) + H2O2 => acrolein + H2O + O2
RHEA:43860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)
REACT:R-DME-210687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT92E transports from the nucleus to the cytosol (Drosophila melanogaster)
RHEA:12912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome] + 2 H(+) + nitrate <=> 2 Fe(III)-[cytochrome] + H2O + nitrite
REACT:R-HSA-5250884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
REACT:R-DME-5654709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
RHEA:64112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-phenylalanine + H2O = a fatty acid + L-phenylalanine
RHEA:15980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelonitrile <=> 4-hydroxybenzaldehyde + hydrogen cyanide
REACT:R-HSA-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Homo sapiens)
REACT:R-XTR-212380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TRAP coactivator complex (Xenopus tropicalis)
REACT:R-CFA-167408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The high affinity receptor complex binds to G-protein (Canis familiaris)
REACT:R-CFA-71335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Canis familiaris)
RHEA:34235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitro-6-oxohepta-2,4-dienedioate = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite
RHEA:41576	skos:prefLabel	"erythronolide mycarosyltransferase"
RHEA:41576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-mycarose + erythronolide B = 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)
RHEA:41576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"erythronolide mycarosyltransferase"
REACT:R-BTA-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Bos taurus)
REACT:R-MMU-8986995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Mus musculus)
REACT:R-RNO-5251942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hikeshi binds HSP70s:ATP (Rattus norvegicus)
RHEA:54360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + H(+) = 3-methylbutanal + CO2
RHEA:43419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:57482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxydodecanoate + H2O => 2-hydroxydodecanoate + H2O2
RHEA:13315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + glycine + H2O2 => H2O + O2 + sarcosine
RHEA:21362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + NAD(+) => ATP + beta-nicotinamide D-ribonucleotide + H(+)
RHEA:37086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine <=> [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine
REACT:R-HSA-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)
REACT:R-GGA-380294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of C-Nap-1 from centrosomes (Gallus gallus)
REACT:R-HSA-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Homo sapiens)
REACT:R-CFA-183072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR non-clathrin mediated endocytosis (Canis familiaris)
REACT:R-XTR-389381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gads binds CD28 (Xenopus tropicalis)
RHEA:44517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)
RHEA:67776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O = a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate
RHEA:17648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate
RHEA:32907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine
RHEA:19373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"saccharopine dehydrogenase (NADP(+), L-lysine-forming)"
RHEA:19373	skos:altLabel	"lysine-2-oxoglutarate reductase"
RHEA:19373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NADP(+) = 2-oxoglutarate + H(+) + L-lysine + NADPH
RHEA:19373	skos:prefLabel	"saccharopine dehydrogenase (NADP(+), L-lysine-forming)"
RHEA:19373	skos:altLabel	"lysine-ketoglutarate reductase"
RHEA:63046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + mevinic carboxylate => H2O + mevastatin
REACT:R-XTR-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)
RHEA:49438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + deoxycholate => cholate + deoxycholoyl-CoA
RHEA:33981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + DIBOA => DIBOA beta-D-glucoside + H2O
GO:0018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkylmercury + H(+) = an alkane + Hg(2+)
GO:0018836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylmercury mercuric-lyase activity
GO:0018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylmercury lyase activity
GO:0018836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	organomercury lyase activity
GO:0018836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	organomercurial lyase activity
GO:0018836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylmercury mercuric-lyase (alkane-forming)
GO:0018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkylmercury lyase"
GO:0018836	skos:altLabel	"organomercury lyase"
GO:0018836	skos:prefLabel	"alkylmercury lyase"
GO:0018836	skos:altLabel	"organomercurial lyase"
GO:0033230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-transporting ATPase activity
GO:0033230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine exporter
GO:0033230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled cysteine transmembrane transporter activity
GO:0033230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine-exporting ATPase activity
GO:0033230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-cysteine(out) = ADP + H(+) + L-cysteine(in) + phosphate
GO:0033230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type cysteine transporter activity
GO:0033230	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled cysteine transporter activity
GO:0033230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent cysteine transporter activity
REACT:R-DRE-6807064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces ZYMOL to ZYMSTNL (Danio rerio)
REACT:R-XTR-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Xenopus tropicalis)
REACT:R-DME-168947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand binds to TLR10 (Drosophila melanogaster)
REACT:R-SSC-2028735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind WWTR1 (TAZ) (Sus scrofa)
REACT:R-MMU-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Mus musculus)
REACT:R-RNO-8863472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAB2 binds LRP2 (Rattus norvegicus)
RHEA:70402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-3-oxosphinganine
RHEA:51065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + lithocholate => adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate
REACT:R-MMU-1602488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by plasmin and trypsin (Mus musculus)
REACT:R-CFA-2454113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 transports 11cRAL to rod photoreceptor outer segment (Canis familiaris)
REACT:R-SSC-177942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EGF ligand (Sus scrofa)
REACT:R-DRE-1638104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Danio rerio)
RHEA:56106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4'-diaponeurosporenal + 2 A + 3 H2O => 2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2
REACT:R-SCE-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)
RHEA:19905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + spermidine = dehydrospermidine + H(+) + NADH
RHEA:72877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A9 + CoA => anthocyanin A7 + malonyl-CoA
REACT:R-BTA-5591086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA5 binds activated protein C (Bos taurus)
RHEA:57894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + 4 H(+)(out) + NADP(+) => a quinone + 5 H(+)(in) + NADPH
RHEA:44997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + acetoacetyl-CoA => CoA + O-3-oxobutanoyl-(R)-carnitine
REACT:R-MMU-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Mus musculus)
REACT:R-CFA-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)
RHEA:28866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + lactose(in) <=> H(+)(in) + lactose(out)
REACT:R-GGA-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Gallus gallus)
REACT:R-MMU-5661230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds arsenic (Mus musculus)
REACT:R-DRE-9028255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises EPA to PGH3 (Danio rerio)
REACT:R-XTR-9661799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)
REACT:R-HSA-381500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin G proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
RHEA:17132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate
GO:0033877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzylsuccinate CoA-transferase activity
GO:0033877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity
GO:0033877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA:benzylsuccinate CoA-transferase activity
GO:0033877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity
REACT:R-DME-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Drosophila melanogaster)
RHEA:47863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b (d18:1(4E)) + H2O <=> ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate
REACT:R-HSA-5633314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates NDRG1 gene expression (Homo sapiens)
RHEA:54100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-RNO-381518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAAP-A proteolyzes IGF:IGFBP4 (Rattus norvegicus)
GO:0070547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine aminotransferase activity
REACT:R-SCE-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)
RHEA:35620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idarate => D-glucarate
REACT:R-CEL-6785648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEMO1 binds RHOA:GTP:DIAPH1 (Caenorhabditis elegans)
REACT:R-GGA-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Gallus gallus)
REACT:R-SSC-77327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Sus scrofa)
REACT:R-SSC-8876446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ULK1 phosphorylates DENND3 (Sus scrofa)
RHEA:35171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + novobiocin(in) = H(+)(in) + novobiocin(out)
REACT:R-DRE-917814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Danio rerio)
REACT:R-RNO-1236940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exogenous soluble antigen targeted to more stable early endosome (Rattus norvegicus)
RHEA:19176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + naphthalene + O2 <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)
REACT:R-GGA-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Gallus gallus)
RHEA:27871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)
RHEA:24621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + octan-1-ol => H(+) + NADH + octanal
REACT:R-HSA-181450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Homo sapiens)
GO:0033941	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-1,6-alpha-D-mannan D-mannohydrolase activity
GO:0033941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannan exo-1,2-1,6-alpha-mannosidase activity
GO:0033941	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,2-1,6-alpha-mannosidase activity
REACT:R-MMU-418918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The UDP/CysLT (P2Y17) receptor can bind UTP (Mus musculus)
RHEA:39614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)
RHEA:69383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-methylpentanoate + O2 <=> 4-methyl-2-oxopentanoate + H2O2
RHEA:62207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal
GO:0032190	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acrosin heavy chain binding
GO:0032190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrosin binding
GO:0032190	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acrosin light chain binding
GO:0032560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanyl deoxyribonucleotide binding
REACT:R-RNO-8848758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates AKT1 (Rattus norvegicus)
REACT:R-CFA-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Canis familiaris)
REACT:R-DME-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Drosophila melanogaster)
RHEA:40253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-carboxy-13-deoxydaunorubicin + H(+) + methanol => 4-O-methylrhodomycin D + H2O
REACT:R-MMU-8848596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds PXN (Mus musculus)
RHEA:67471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine
REACT:R-BTA-9013109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GEFs activate RHOC (Bos taurus)
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hexose monophosphate isomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-6-phosphate isomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglucose isomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglucoisomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose-6-phosphate aldose-ketose-isomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphohexomutase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexose phosphate isomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxoisomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose phosphate isomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphohexoisomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphohexose isomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphosaccharomutase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose-6-phosphate ketol-isomerase activity
GO:0004347	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hexosephosphate isomerase activity
REACT:R-SSC-110231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by MBD4 glycosylase (Sus scrofa)
REACT:R-BTA-9638078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from keratan sulfate (Bos taurus)
REACT:R-HSA-9020261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Homo sapiens)
GO:0102146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + tricetin = 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine
GO:0102146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tricetin O-methytransferase activity
RHEA:15533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH
REACT:R-HSA-1445149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)
REACT:R-MMU-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Mus musculus)
REACT:R-DRE-5693593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop extension by DNA polymerases (Danio rerio)
RHEA:68881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + salicylate => AMP + diphosphate + NADP(+) + salicylaldehyde
RHEA:72306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + L-thyroxine(out) <=> L-glutamate(out) + L-thyroxine(in)
REACT:R-MMU-388830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds ICOS (Mus musculus)
RHEA:52487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2
RHEA:42201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + NADP(+) => 11-dehydrocorticosterone + H(+) + NADPH
GO:0140702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic GMP-AMP binding
RHEA:50424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1
RHEA:63390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + Fe(II)-heme a => 2 A + Fe(II)-heme o + H2O
GO:0047326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol tetrakisphosphate 5-kinase activity
GO:0047326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,3,4,6-tetrakisphosphate 5-kinase activity
GO:0047326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity
GO:0047326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol-tetrakisphosphate 5-kinase activity
GO:0047326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-tetrakisphosphate 5-kinase activity
REACT:R-DDI-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-XTR-2187405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 binds phosphorylated SMAD2/3 (Xenopus tropicalis)
RHEA:60090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4alpha-methyl-3-oxosteroid + CO2 + NADPH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+)
REACT:R-HSA-9694790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E protein gets N-glycosylated (Homo sapiens)
REACT:R-BTA-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Bos taurus)
REACT:R-SSC-8956025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Sus scrofa)
RHEA:27666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA
RHEA:21607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	styrene oxide <=> 2-phenylacetaldehyde
REACT:R-HSA-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Homo sapiens)
REACT:R-XTR-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Xenopus tropicalis)
RHEA:64175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-altrarate <=> galactarate
REACT:R-HSA-392143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NO binds to Guanylate Cyclase (Homo sapiens)
REACT:R-MMU-9749583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Mus musculus)
REACT:R-XTR-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)
REACT:R-BTA-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Bos taurus)
REACT:R-GGA-421478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen III + 2 O2 => protoporphyrinogen IX + 2 H2O2 + 2 CO2 (Gallus gallus)
RHEA:66265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + nonanoate => diphosphate + nonanoyl-AMP
REACT:R-SSC-2730884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of NTAL by p-SYK/Lyn (Sus scrofa)
RHEA:58938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopaoctaene + 2 diphosphate + NAD(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH
REACT:R-SCE-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Saccharomyces cerevisiae)
RHEA:31520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + torulene => 3-methyl-2-butenal + 4'-apo-beta-carotenal
RHEA:59548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N',N''-triacetylchitotriose + O2 = H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone
REACT:R-HSA-8849906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM1 binds NMDA receptor (Homo sapiens)
REACT:R-DRE-5362525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)
RHEA:24606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + theobromine => 7-methylxanthine + S-adenosyl-L-methionine
REACT:R-HSA-199443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Homo sapiens)
REACT:R-MMU-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Mus musculus)
REACT:R-BTA-9664855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Bos taurus)
RHEA:13929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O = putrescine + urea
RHEA:13929	skos:prefLabel	"agmatinase"
RHEA:13929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"agmatinase"
RHEA:13929	skos:altLabel	"agmatine ureohydrolase"
REACT:R-XTR-879377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Xenopus tropicalis)
REACT:R-SSC-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Sus scrofa)
REACT:R-DRE-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Danio rerio)
REACT:R-XTR-8956365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Xenopus tropicalis)
RHEA:30510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinone-8 + H(+) + NADH <=> 2-demethylmenaquinol-8 + NAD(+)
RHEA:17416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:61809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP => AMP + H(+) + L-alanyl-[peptidyl-carrier protein]
RHEA:45048	skos:altLabel	"acylase"
RHEA:45048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amidase"
RHEA:45048	skos:altLabel	"acylamidase"
RHEA:45048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetamide + H2O = acetate + NH4(+)
RHEA:45048	skos:prefLabel	"amidase"
REACT:R-DDI-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Dictyostelium discoideum)
REACT:R-SSC-266303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds C and E apolipoproteins (Sus scrofa)
GO:0050595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganin 7-hydroxylase activity
GO:0050595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-deoxyloganin,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
RHEA:22715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide phosphate + GTP + H(+) <=> adenosylcob(III)inamide-GDP + diphosphate
REACT:R-SSC-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Sus scrofa)
REACT:R-DRE-5690991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Danio rerio)
REACT:R-GGA-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Gallus gallus)
REACT:R-GGA-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Gallus gallus)
RHEA:12291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucoside + H2O <=> an alcohol + L-fucose
RHEA:54685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => (-)-kolavenyl diphosphate
RHEA:45179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:55130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-5-methylhexenoyl-[ACP] + H2O => (3R)-hydroxy-5-methylhexanoyl-[ACP]
REACT:R-RNO-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Rattus norvegicus)
RHEA:33280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:19249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
GO:0031753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endothelial differentiation G protein-coupled receptor binding
GO:0031753	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endothelial differentiation G-protein coupled receptor ligand
GO:0031753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endothelial differentiation G-protein coupled receptor binding
RHEA:28350	skos:prefLabel	"UDP-arabinopyranose mutase"
RHEA:28350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose
RHEA:28350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-arabinopyranose mutase"
REACT:R-HSA-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Homo sapiens)
REACT:R-HSA-9702354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCA antibodies (Homo sapiens)
REACT:R-SSC-9012268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)
RHEA:43535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 3',5'-bisphosphate + H2O <=> a ribonucleoside 5'-phosphate + phosphate
RHEA:25791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxoheptanedioate <=> pyruvate + succinate semialdehyde
REACT:R-DRE-8948800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNKS and TNKS2 PARylate PTEN (Danio rerio)
RHEA:18148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose <=> ADP + beta-D-fructose 1-phosphate + H(+)
REACT:R-MMU-1504186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL recruits GSK3beta:AXIN1 to the receptor complex (Mus musculus)
RHEA:45568	skos:prefLabel	"heparosan-glucuronate 5-epimerase"
RHEA:45568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heparosan-glucuronate 5-epimerase"
RHEA:45568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparosan](n) = [acharan](n)
GO:0052901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N(1)-acetylpolyamine oxidase activity
GO:0052901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	spermine oxidase activity
GO:0052901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermine:oxygen oxidoreductase (spermidine-forming) activity
GO:0052901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	non-specific polyamine oxidase activity
GO:0052901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyamine oxidase activity
RHEA:19815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuccinamate + an L-alpha-amino acid => a 2-oxocarboxylate + L-asparagine
RHEA:42838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+) => acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH
RHEA:36072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-tuliposide A => D-glucose + tulipalin A
RHEA:51444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine
REACT:R-HSA-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Homo sapiens)
RHEA:49325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R,6S)-5,6-epoxi-capsanthin => all-trans-capsorubin
GO:0102310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity
REACT:R-SSC-1483089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is converted to PS by PTDSS2 (Sus scrofa)
GO:0042912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	colicin transmembrane transporter activity
RHEA:68165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Homo sapiens)
RHEA:22295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> biphenyl-3,5-diol + 4 CO2 + 4 CoA
REACT:R-CFA-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Canis familiaris)
RHEA:32606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-oxogeraniol + H(+) + NADPH
RHEA:40555	skos:prefLabel	"L-evernosamine nitrososynthase"
RHEA:40555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-evernosamine nitrososynthase"
RHEA:40555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)
REACT:R-DRE-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
REACT:R-HSA-2473151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)
REACT:R-PFA-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Plasmodium falciparum)
RHEA:24148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:24148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)"
RHEA:24148	skos:altLabel	"glyceraldehyde-3-phosphate Fd oxidoreductase"
RHEA:24148	skos:altLabel	"GAPOR"
RHEA:24148	skos:prefLabel	"glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)"
RHEA:24148	skos:altLabel	"glyceraldehyde-3-phosphate ferredoxin reductase"
REACT:R-DRE-9026894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK2 (Danio rerio)
REACT:R-SSC-750988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (z) reassociates with G beta:gamma (Sus scrofa)
REACT:R-RNO-8950210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 dissociates from Interleukin-27 receptor (Rattus norvegicus)
REACT:R-HSA-77274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Homo sapiens)
RHEA:71509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-tocopherol(in) => (+)-alpha-tocopherol(out)
RHEA:26554	skos:prefLabel	"angiotensin-converting enzyme 2"
RHEA:26554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"angiotensin-converting enzyme 2"
RHEA:26554	skos:altLabel	"angiotensin converting enzyme-2"
RHEA:26554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine
RHEA:26554	skos:altLabel	"angiotensin converting enzyme 2"
RHEA:26554	skos:altLabel	"ACE2"
GO:0030779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity
GO:0030779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxydihydrosanguinarine 10-O-methyltransferase activity
RHEA:47877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b + H2O => ganglioside GM1 + N-acetylneuraminate
RHEA:62631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxide + H(+) + NADH <=> an alcohol + H2O + NAD(+)
RHEA:63107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ilicicolin A epoxide + NADPH + O2 <=> 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)
REACT:R-HSA-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Homo sapiens)
REACT:R-CEL-6814187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVL:PPL heterodimer binds the inner surface of the plasma membrane (Caenorhabditis elegans)
RHEA:34009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine => 7-dehydrodesmosterol + S-adenosyl-L-methionine
REACT:R-PFA-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Plasmodium falciparum)
RHEA:25517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + tropine => CoA + H(+) + O-acyltropine
REACT:R-HSA-9725023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 (Homo sapiens)
RHEA:33630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + decanoate <=> AMP + decanoyl-CoA + diphosphate
REACT:R-RNO-162836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Rattus norvegicus)
REACT:R-SPO-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Schizosaccharomyces pombe)
RHEA:38300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA
REACT:R-BTA-9650165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers bind H+ (Bos taurus)
REACT:R-CFA-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Canis familiaris)
REACT:R-XTR-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Xenopus tropicalis)
REACT:R-BTA-168440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Bos taurus)
GO:0047609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylputrescine deacetylase activity
GO:0047609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylputrescine acetylhydrolase activity
RHEA:63139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione <=> cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione
REACT:R-DME-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Drosophila melanogaster)
REACT:R-SSC-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Sus scrofa)
REACT:R-HSA-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Homo sapiens)
GO:0016753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-sinapoyltransferase activity
REACT:R-HSA-8876258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates InlB-bound MET (Homo sapiens)
REACT:R-DRE-2179276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 monoubiquitinates SMAD3 (Danio rerio)
RHEA:49601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + octanedioate => AMP + diphosphate + octanedioyl-CoA
RHEA:40326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DME-9758090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Drosophila melanogaster)
RHEA:22138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide b + 2 H2O + NADP(+) => 7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2
GO:0102218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	starch, H2O dikinase activity
RHEA:57120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
RHEA:28203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-BTA-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Bos taurus)
RHEA:61023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA <=> 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine
REACT:R-BTA-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Bos taurus)
RHEA:33478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)
REACT:R-BTA-8873794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCTP binds PC (Bos taurus)
REACT:R-DRE-9709406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to Cytochrome c oxidase (Danio rerio)
RHEA:45542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)
REACT:R-RNO-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)
RHEA:56072	skos:prefLabel	"acylphloroglucinol glucosyltransferase"
RHEA:56072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acylphloroglucinol glucosyltransferase"
RHEA:56072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylphloroglucinol + UDP-alpha-D-glucose = a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP
RHEA:56072	skos:altLabel	"UGT71K3"
RHEA:38319	skos:prefLabel	"chorismatase"
RHEA:38319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chorismatase"
RHEA:38319	skos:altLabel	"chorismate/3,4-dihydroxycyclohexa-1,5-dienoate synthase"
RHEA:38319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + H2O = (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate
REACT:R-MMU-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Mus musculus)
REACT:R-RNO-5649725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Rattus norvegicus)
REACT:R-HSA-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Homo sapiens)
GO:1904408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melatonin binding
REACT:R-XTR-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Xenopus tropicalis)
RHEA:48553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => (10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)
RHEA:15031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose + H(+) + NADH => D-mannitol + NAD(+)
RHEA:58890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrobenzoate + A + 2 H2O => 4-aminobenzoate + AH2 + 2 O2
REACT:R-DRE-1112514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK activation (Danio rerio)
RHEA:64193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-lysine => (9Z)-octadecenoate + L-lysine
REACT:R-RNO-1855208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Rattus norvegicus)
REACT:R-XTR-5654596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)
GO:0019144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-sugar sugarphosphohydrolase activity
GO:0019144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADPsugar pyrophosphatase activity
GO:0019144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphosugar pyrophosphatase activity
GO:0019144	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleoside diphosphate-sugar hydrolase activity
GO:0019144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-sugar diphosphatase activity
GO:0019144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-sugar pyrophosphatase activity
RHEA:65546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc => ganglioside GM1 + H2O
REACT:R-CFA-8851908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 (Canis familiaris)
REACT:R-HSA-6807008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates MET (Homo sapiens)
REACT:R-HSA-9694406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp13 binds DDX5 (Homo sapiens)
REACT:R-XTR-5683967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Xenopus tropicalis)
RHEA:19682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin + CoA => AMP + biotinyl-CoA + diphosphate
REACT:R-DME-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Drosophila melanogaster)
RHEA:37372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP
RHEA:63976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydropyriculariol = AH2 + pyriculariol
REACT:R-BTA-2187261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC12 (SCARA4) binds ligands (Bos taurus)
REACT:R-HSA-1678920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR processing at low pH (Homo sapiens)
REACT:R-HSA-452958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SALL1 (Homo sapiens)
REACT:R-BTA-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Bos taurus)
REACT:R-DRE-1483089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is converted to PS by PTDSS2 (Danio rerio)
RHEA:41179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)
REACT:R-BTA-376364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp8 associated secretory vesicle to plasma membrane transport (Bos taurus)
GO:0018635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-limonene,NAD(P)H:oxygen oxidoreductase activity
GO:0018635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-limonene 1,2-monooxygenase activity
GO:0018635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-limonene,NAD(P)H:oxygen oxidoreductase activity
GO:0018635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-limonene 1,2-monooxygenase activity
REACT:R-DRE-9667569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,2 bind AVPR antagonists (Danio rerio)
REACT:R-HSA-430073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)
RHEA:60914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine
RHEA:14938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Homo sapiens)
REACT:R-CEL-2395965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)
REACT:R-BTA-8848939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds KHDRBS1 (Bos taurus)
REACT:R-RNO-159101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Rattus norvegicus)
RHEA:67208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + melatonin = 5-methoxytryptamine + acetate
RHEA:15863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ADP-glycerate + phosphate => 3-ADP-2-phosphoglycerate + H2O
RHEA:29271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + H(+) + trimethylamine N-oxide = a menaquinone + H2O + trimethylamine
RHEA:17557	skos:prefLabel	"anthranilate N-malonyltransferase"
RHEA:17557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthranilate N-malonyltransferase"
RHEA:17557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + malonyl-CoA = CoA + N-malonylanthranilate
RHEA:67337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 3-O-beta-D-glucoside + malonyl-CoA => CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)
RHEA:69929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(in) + Na(+)(in) => adenosine(out) + Na(+)(out)
REACT:R-XTR-8956676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TP73 (Xenopus tropicalis)
REACT:R-HSA-1250264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP binds reduced thioredoxin (Homo sapiens)
REACT:R-HSA-8938176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds the PF4 gene promoter (Homo sapiens)
REACT:R-HSA-8954182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter (Homo sapiens)
REACT:R-HSA-9733960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids dissociate from ALB (Homo sapiens)
RHEA:56070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose
RHEA:32386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-limonene-1,2-diol + NAD(+) <=> (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH
RHEA:37183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-5218819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-MMU-8850539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GNB5:RGS dimers from CCT/TRiC (Mus musculus)
RHEA:45167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
RHEA:27824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-homocysteine => hydrogen sulfide + O-acetyl-L-homoserine
REACT:R-SCE-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Saccharomyces cerevisiae)
RHEA:49955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10aS)-10,10a-dihydrophenazine-1-carboxylate <=> 5,10-dihydrophenazine 1-carboxylate
RHEA:32198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18,18-diol <=> abieta-7,13-dien-18-al + H2O
REACT:R-MMU-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Mus musculus)
RHEA:29166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) <=> 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)
REACT:R-DME-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Drosophila melanogaster)
REACT:R-BTA-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Bos taurus)
RHEA:64933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + 2 H2O => dGMP + 2 H(+) + 2 phosphate
REACT:R-RNO-191636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cx43 by c-src (Rattus norvegicus)
REACT:R-SCE-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Saccharomyces cerevisiae)
REACT:R-BTA-5252079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Bos taurus)
REACT:R-DME-209381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-1 transcription factor, JRA:KAY, is phosphorylated by phosphorylated BSK kinase (Drosophila melanogaster)
REACT:R-GGA-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Gallus gallus)
REACT:R-XTR-194017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 11DCORST to CORST (Xenopus tropicalis)
REACT:R-XTR-4793925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S303,307-HSF1 binds YWHAE (14-3-3) (Xenopus tropicalis)
GO:0047080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine 2-oxoglutarate dioxygenase activity
GO:0047080	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thymidine 2'-dioxygenase activity
GO:0047080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine 2'-hydroxylase activity
GO:0047080	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyrimidine deoxyribonucleoside 2'-hydroxylase activity
GO:0047080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyuridine 2'-dioxygenase activity
GO:0047080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyuridine 2'-hydroxylase activity
GO:0047080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)
GO:0047080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine dioxygenase activity
GO:0047080	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity
GO:0047080	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyrimidine-deoxynucleoside 2'-dioxygenase activity
REACT:R-HSA-8951695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TEADs:YAP1 binds CTGF gene (Homo sapiens)
REACT:R-SSC-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Sus scrofa)
RHEA:61816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16,17-didehydropregnenolone + UDP-alpha-D-glucose = 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP
RHEA:72527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine
RHEA:24205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + H(+) + sulfite => phosphate + sulfoacetaldehyde
REACT:R-DRE-376122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM/DSCAML1 homodimerization (Danio rerio)
REACT:R-XTR-9033961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Xenopus tropicalis)
REACT:R-XTR-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Xenopus tropicalis)
REACT:R-GGA-4085021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Gallus gallus)
RHEA:62811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:62527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(839) in 12S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine
RHEA:25835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-chiro-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosine
REACT:R-SSC-5205649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 links damaged mitochondria to LC3 (Sus scrofa)
RHEA:51208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH
RHEA:68445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-cis-lycopene + O2 => (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal
RHEA:50966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + uridine(8) in tRNA => cytidine(8) in tRNA + H(+) + H2O
REACT:R-SCE-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Saccharomyces cerevisiae)
REACT:R-CEL-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Caenorhabditis elegans)
RHEA:44053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA
REACT:R-XTR-622420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Xenopus tropicalis)
RHEA:47946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl phosphate + H(+) + phosphate => (2E)-geranyl diphosphate + H2O
GO:0004985	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	opioid receptor activity
GO:0004985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled opioid receptor activity
REACT:R-SSC-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Sus scrofa)
RHEA:33721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine
REACT:R-DRE-8848726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates BCAR1 (Danio rerio)
REACT:R-SSC-389826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NADPH + H+ => glycolate + NADP+ (Sus scrofa)
REACT:R-HSA-9007646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX5 gene expression is inhibited by E2F6 (Homo sapiens)
REACT:R-HSA-6800870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the FP subcomplex (Homo sapiens)
REACT:R-SPO-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Schizosaccharomyces pombe)
RHEA:38873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(2457) in 23S rRNA => uridine(2457) in 23S rRNA
RHEA:33526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O <=> acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)
RHEA:32547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (1R,5R)-sabinene + diphosphate
RHEA:32547	skos:prefLabel	"(+)-sabinene synthase"
RHEA:32547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-sabinene synthase"
RHEA:22041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-aspartate => formate + L-aspartate
REACT:R-XTR-192178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)
REACT:R-HSA-9683546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN binds furin inhibitors (Homo sapiens)
REACT:R-MMU-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Mus musculus)
REACT:R-CEL-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Caenorhabditis elegans)
REACT:R-CFA-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Canis familiaris)
REACT:R-CEL-975629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11 reduces RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)
GO:0008730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-(+)-tartaric acid dehydratase activity
GO:0008730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L(+)-tartrate dehydratase activity
GO:0008730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R,R)-tartrate hydro-lyase activity
GO:0008730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tartaric acid dehydrase activity
GO:0008730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R,R)-tartrate hydro-lyase (oxaloacetate-forming)
GO:0008730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tartrate dehydratase activity
GO:0008730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tartrate dehydratase activity
REACT:R-DRE-264689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Danio rerio)
RHEA:13689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diphosphate--glycerol phosphotransferase"
RHEA:13689	skos:altLabel	"pyrophosphate--glycerol phosphotransferase"
RHEA:13689	skos:prefLabel	"diphosphate--glycerol phosphotransferase"
RHEA:13689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + glycerol = glycerol 1-phosphate + H(+) + phosphate
REACT:R-DRE-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Danio rerio)
REACT:R-XTR-5622134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRABP1 binds atRA (Xenopus tropicalis)
REACT:R-MMU-450222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Mus musculus)
REACT:R-XTR-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Xenopus tropicalis)
REACT:R-CFA-1222685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathelicidin LL-37 binds to bacterial cell wall (Canis familiaris)
RHEA:69140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(4-aminobutyl)-3-aminopropanal = acrolein + putrescine
RHEA:23812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-neomenthol dehydrogenase"
RHEA:23812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-neomenthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH
RHEA:23812	skos:altLabel	"monoterpenoid dehydrogenase"
RHEA:23812	skos:prefLabel	"(+)-neomenthol dehydrogenase"
EC:1.14.99.64	skos:prefLabel	"zeaxanthin 4-ketolase"
EC:1.14.99.64	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zeaxanthin 4-ketolase"
RHEA:36661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	novobiocin + phosphate => carbamoyl phosphate + descarbamoylnovobiocin
REACT:R-HSA-5617652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXD3 mRNA is translated (Homo sapiens)
REACT:R-XTR-2730858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of BTK/ITK (Xenopus tropicalis)
RHEA:28556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose + phosphate => D-mannose 6-phosphate + H2O
REACT:R-SCE-1482827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Saccharomyces cerevisiae)
RHEA:53849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + taurocholate => 7-oxo-taurodeoxycholate + H(+) + NADH
REACT:R-BTA-927830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Bos taurus)
REACT:R-GGA-997311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of TYK2 by PTP1B (Gallus gallus)
REACT:R-PFA-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Plasmodium falciparum)
REACT:R-GGA-8985973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Gallus gallus)
RHEA:57845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fraxetin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)
RHEA:45591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + holo-[ACP] <=> a long-chain fatty acyl-[ACP] + AMP + diphosphate
RHEA:21982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)
REACT:R-DME-5610752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R translocates to the nucleus (Drosophila melanogaster)
REACT:R-MMU-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Mus musculus)
RHEA:47998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NAD(+) => 1,6-dihydro-beta-NAD + H(+) + O2
RHEA:23207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorogenate + D-glucarate <=> 2-O-caffeoylglucarate + L-quinate
REACT:R-GGA-5625424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The retrograde IFT train dissociates (Gallus gallus)
REACT:R-DRE-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Danio rerio)
RHEA:10987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + oxaloacetate <=> (S)-malate + pyruvate
REACT:R-HSA-1989766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CTGF (Homo sapiens)
EC:6.2.2.-	skos:prefLabel	"Amide--thiol ligases"
EC:6.2.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Amide--thiol ligases"
REACT:R-HSA-2134519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)
REACT:R-RNO-77263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Rattus norvegicus)
RHEA:29483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-beta-selinene + diphosphate
REACT:R-CEL-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)
GO:0047404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O = D-glucuronate + N(2),6-disulfo-D-glucosamine
GO:0047404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronosyl-disulfoglucosamine glucuronidase activity
GO:0047404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronosyl-disulphoglucosamine glucuronidase activity
GO:0047404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity
GO:0047404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity
GO:0047404	skos:prefLabel	"glucuronosyl-disulfoglucosamine glucuronidase"
GO:0047404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronosyl-disulfoglucosamine glucuronidase"
REACT:R-XTR-4084994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU3 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)
GO:0002112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-33 receptor binding
GO:0002112	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-33
GO:0002112	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-33 receptor ligand
RHEA:67936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxy carboxylate + O2 = a 2-oxocarboxylate + H2O2
REACT:R-SSC-6781897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP11 deubiquitinates NFKBIA (Sus scrofa)
REACT:R-XTR-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Xenopus tropicalis)
REACT:R-HSA-432172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
REACT:R-DRE-4755536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates RELA with SUMO3 (Danio rerio)
REACT:R-HSA-6786072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3,p-Y641-STAT6 dissociate (Homo sapiens)
REACT:R-BTA-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)
REACT:R-SPO-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)
RHEA:21730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH => GDP-alpha-D-mannose + H2O + 2 NAD(+)
REACT:R-GGA-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Gallus gallus)
REACT:R-CFA-6807134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)
REACT:R-DME-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)
REACT:R-BTA-156723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF20A (MKL2) by phosphorylation (Bos taurus)
REACT:R-RNO-2395764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atREs binds to nascent CM (Rattus norvegicus)
RHEA:53278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:14413	skos:prefLabel	"biphenyl-2,3-diol 1,2-dioxygenase"
RHEA:14413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biphenyl-2,3-diol 1,2-dioxygenase"
RHEA:14413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)
RHEA:14413	skos:altLabel	"2,3-dihydroxybiphenyl dioxygenase"
GO:0008704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHDD isomerase activity
GO:0008704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethyl-2-hydroxymuconate D-isomerase activity
GO:0008704	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hpaG-1
GO:0008704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity
GO:0008704	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-carboxymethyl-2-hydroxymuconic acid isomerase activity
GO:0008704	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hpaG1
GO:0008704	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
GO:0008704	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CHM isomerase activity
GO:0008704	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity
REACT:R-HSA-8847638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Homo sapiens)
REACT:R-CFA-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Canis familiaris)
GO:0051508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stigmasterol UDP-glucosyltransferase activity
REACT:R-SSC-216757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Sus scrofa)
REACT:R-MMU-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Mus musculus)
GO:0003940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-iduronidase activity
GO:0003940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycosaminoglycan alpha-L-iduronohydrolase activity
GO:0003940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-L-iduronidase activity
GO:0034879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6-trihydroxyisonicotinate decarboxylase activity
REACT:R-HSA-9027281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Homo sapiens)
REACT:R-SSC-2430535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL phosphorylates ENSA (Sus scrofa)
GO:0017064	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	anandamide amidohydrolase activity
GO:0017064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid amide hydrolase activity
GO:0017064	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oleamide hydrolase activity
GO:0017064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH2 hydrolyses AEA to AA and ETA (Homo sapiens)
RHEA:55344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA
REACT:R-DRE-9615348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR2 (Danio rerio)
REACT:R-HSA-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Homo sapiens)
GO:0098960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	postsynaptic neurotransmitter receptor activity
GO:0098960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter receptor activity involved in chemical synaptic transmission
REACT:R-DME-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Drosophila melanogaster)
RHEA:62407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyhexadecanoate + O2 <=> CO2 + H2O + pentadecanoate
REACT:R-BTA-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Bos taurus)
RHEA:66187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP(in) + ATP + H2O <=> 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate
REACT:R-HSA-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Homo sapiens)
EC:3.3.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Ether hydrolases"
EC:3.3.2.-	skos:prefLabel	"Ether hydrolases"
REACT:R-BTA-6787540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUK phosphorylates beta-Fuc to Fuc1P (Bos taurus)
RHEA:33217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate + 3 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate
REACT:R-DRE-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Danio rerio)
REACT:R-XTR-158333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Xenopus tropicalis)
REACT:R-DME-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)
REACT:R-DRE-3239014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates TP53 (Danio rerio)
REACT:R-SSC-163670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear transport of pChREBP (Thr 666) protein (Sus scrofa)
REACT:R-HSA-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Homo sapiens)
REACT:R-DME-5654664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)
REACT:R-CFA-2161779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LXA4 is oxidised to 15k-LXA4 by HPGD (Canis familiaris)
RHEA:47708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-glucose 1-phosphate + H(+) = ADP-alpha-D-glucose + phosphate
RHEA:69478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-acetyl-L-lysine => acetyl-CoA + L-lysine
RHEA:62677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide => 6-thio-IMP + 7,8-dihydrofolate + H2O
REACT:R-HSA-5663002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds copper (Homo sapiens)
REACT:R-MMU-8941628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)
GO:0045508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-26R
GO:0045508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-26 receptor activity
GO:0045508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-26 receptor activity
REACT:R-MMU-140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)
RHEA:29974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine(in) + H(+)(in) <=> 2'-deoxyinosine(out) + H(+)(out)
RHEA:29070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) + menaquinone-8 <=> CO2 + menaquinol-8
RHEA:39537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA
REACT:R-BTA-9033959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Bos taurus)
RHEA:16516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + O2 <=> acetate + CO2 + H2O
RHEA:32920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl (indol-3-yl)acetate => (indol-3-yl)acetate + H(+) + methanol
REACT:R-SSC-1433488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHP2 by SFKs (Sus scrofa)
REACT:R-CEL-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Caenorhabditis elegans)
REACT:R-RNO-428262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Rattus norvegicus)
RHEA:32986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol
RHEA:42491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III <=> 3'-N-debenzoyl-2'-deoxytaxol + CoA
RHEA:68971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mandelate + O2 <=> H2O2 + phenylglyoxylate
REACT:R-BTA-2562594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated OPTN translocates to the nucleus (Bos taurus)
GO:0047558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyanoalanine hydratase activity
GO:0047558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-asparagine hydro-lyase (3-cyanoalanine-forming)
GO:0047558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-CNA nitrilase activity
GO:0047558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyanoalanine hydrolase activity
GO:0047558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-asparagine hydro-lyase activity
GO:0047558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-cyanoalanine hydratase activity
GO:0047558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-CNAla hydrolase activity
RHEA:46423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Drosophila melanogaster)
REACT:R-DRE-9707504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 oxidises ferrohemoglobin to MetHb (Danio rerio)
RHEA:63873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-isoleucine + O2 => 3(1)-hydroxy-L-isoleucine + CO2 + succinate
REACT:R-RNO-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Rattus norvegicus)
RHEA:37525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:37815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate
REACT:R-CEL-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Caenorhabditis elegans)
REACT:R-CFA-5635845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind CDC73 (Canis familiaris)
RHEA:52834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => 1-hydroxylimonen-2-one + H(+) + NADPH + O2
REACT:R-DME-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Drosophila melanogaster)
REACT:R-BTA-174731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of newly synthesized ApoB-48 (Bos taurus)
REACT:R-GGA-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Gallus gallus)
REACT:R-MMU-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Mus musculus)
RHEA:54620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + eicosanoyl-CoA + O2 = 2-hydroxyeicosanoyl-CoA + CO2 + succinate
RHEA:42119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH
RHEA:59254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate
RHEA:15382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + quercetin => 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
RHEA:30222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + H2O + NAD(+) <=> dimethyl sulfone + H(+) + NADH
RHEA:69528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + H2O + 2 L-glutamine = 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)
RHEA:38047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:67597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptadecasphing-4-enine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine
RHEA:24387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + deamido-NAD(+) + H2O + L-glutamine <=> AMP + diphosphate + H(+) + L-glutamate + NAD(+)
REACT:R-GGA-400677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rnd1 interacts with Plexin-B1:Sema4D (Gallus gallus)
RHEA:69194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[tubulin]
REACT:R-DME-390112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated HPO dimer phosphorylates WTS (Drosophila melanogaster)
RHEA:51869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + umbelliferone => demethylsuberosin + diphosphate
RHEA:49558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-cysteinyl-[protein] + lactate => H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]
REACT:R-SSC-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Sus scrofa)
REACT:R-BTA-389897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Bos taurus)
GO:0036189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-diene hydroxylase activity
GO:0036189	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	abietadiene hydroxylase
REACT:R-DRE-176631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Danio rerio)
RHEA:56171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-RNO-166220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion diffuses laterally to UCP (Rattus norvegicus)
REACT:R-HSA-1299359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TALK (Homo sapiens)
REACT:R-DRE-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Danio rerio)
RHEA:62017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:27852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + phenylacetylglycine => glycine + phenylacetyl-CoA
RHEA:36786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine
RHEA:70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(out) + L-glutamine(in) + Na(+)(out) <=> L-alanine(in) + L-glutamine(out) + Na(+)(in)
RHEA:55129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-5-methylhexanoyl-[ACP] => (2E)-5-methylhexenoyl-[ACP] + H2O
RHEA:37419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-HSA-450358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Homo sapiens)
RHEA:36481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA
RHEA:36531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA = (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA
REACT:R-BTA-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Bos taurus)
RHEA:63442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate => (2R)-3-phosphoglycerate + GTP + H(+)
RHEA:50333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-170070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Sus scrofa)
RHEA:52799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + Ni-sirohydrochlorin <=> Ni(2+) + sirohydrochlorin
RHEA:69321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucoerucin + H2O => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose
REACT:R-HSA-6798139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates CASP10 expression (Homo sapiens)
RHEA:61737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolmonoside + UDP-alpha-D-glucose => rubusoside + UDP
EC:1.14.19.36	skos:prefLabel	"sn-1 acyl-lipid omega-3 desaturase (ferredoxin)"
EC:1.14.19.36	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sn-1 acyl-lipid omega-3 desaturase (ferredoxin)"
REACT:R-MMU-9757951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
RHEA:69471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose <=> L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose
GO:0047689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aspartate racemase activity
GO:0047689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate racemase activity
REACT:R-SPO-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Schizosaccharomyces pombe)
REACT:R-RNO-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Rattus norvegicus)
GO:0034617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydrobiopterin binding
GO:0034617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sapropterin binding
GO:0034617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H4biopterin binding
GO:0034617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH4 binding
REACT:R-HSA-5205799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)
RHEA:69461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine => [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine
REACT:R-HSA-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Homo sapiens)
REACT:R-RNO-8942099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Rattus norvegicus)
RHEA:10182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH => (6S)-10-formyltetrahydrofolate + H2O + NADP(+)
REACT:R-DRE-933536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7 dimer interacts with coactivator CBP/p300 (Danio rerio)
REACT:R-CEL-374680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 trans-homophilic interaction (Caenorhabditis elegans)
RHEA:40728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid => a 1-acylglycerone 3-phosphate + hexadecanoate
REACT:R-DRE-2160851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAS1,2,3 mediate the polymerisation of HA (Danio rerio)
REACT:R-DRE-400092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Danio rerio)
REACT:R-SSC-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Sus scrofa)
RHEA:52204	skos:prefLabel	"chloroacetanilide N-alkylformylase"
RHEA:52204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chloroacetanilide N-alkylformylase"
RHEA:52204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-350604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Agmatine + H2O <=> putrescine + urea (Canis familiaris)
RHEA:30697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + 2 H(+) + NADH => 3-aminopropanal + H2O + NAD(+)
REACT:R-BTA-8937369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAD2 binds ESR1 (Bos taurus)
RHEA:18007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose + H(+) + NADPH => D-threitol + NADP(+)
RHEA:33575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphophytoceramide + beta-D-mannose = a mannosylinositol-1-phosphophytoceramide + H2O
RHEA:23062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP
RHEA:29763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate
RHEA:14143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + 2 glutathione => AMP + glutathione disulfide + 2 H(+) + sulfite
REACT:R-DRE-69685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TP53 (Danio rerio)
RHEA:68523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> beta-acoradiene + diphosphate
RHEA:38314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carminomycin + S-adenosyl-L-methionine <=> daunorubicin + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-2395302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysino-5-ketonorleucine cross-links (Bos taurus)
REACT:R-MMU-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)
REACT:R-GGA-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Gallus gallus)
RHEA:37282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-histidine(out) <=> ADP + H(+) + L-alanyl-L-histidine(in) + phosphate
REACT:R-CFA-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Canis familiaris)
REACT:R-HSA-452894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SOX2 (Homo sapiens)
RHEA:48493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP
RHEA:64184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-tyrosine = (9Z)-octadecenoate + L-tyrosine
RHEA:42324	skos:prefLabel	"coenzyme F420 oxidoreductase (ferredoxin)"
RHEA:42324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coenzyme F420 oxidoreductase (ferredoxin)"
RHEA:42324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) = 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:25978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Bos taurus)
REACT:R-MMU-158722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Mus musculus)
REACT:R-PFA-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Plasmodium falciparum)
REACT:R-MMU-977359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to membrane-associated Factor H:C3b (Mus musculus)
REACT:R-HSA-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Homo sapiens)
REACT:R-DRE-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Danio rerio)
RHEA:38148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon disulfide + H2O => carbonyl sulfide + H(+) + hydrogen sulfide
REACT:R-RNO-9756169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)
RHEA:29191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + menaquinone-8 = iminosuccinate + menaquinol-8
RHEA:12779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4,7-dihydroxypteridine + chemical entity => 2-amino-4-hydroxypteridine + O2
REACT:R-CFA-76453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A6 (Canis familiaris)
REACT:R-BTA-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Bos taurus)
REACT:R-HSA-2424480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-RNO-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Rattus norvegicus)
REACT:R-HSA-4755536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)
GO:0050012	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)
GO:0050012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juglone 3-monooxygenase activity
GO:0050012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juglone 3-hydroxylase activity
GO:0050012	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	naphthoquinone hydroxylase activity
GO:0050012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juglone hydroxylase activity
REACT:R-RNO-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Rattus norvegicus)
RHEA:39972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate => 2-aminobut-2-enoate
REACT:R-GGA-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Gallus gallus)
REACT:R-GGA-2132248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to target cell surface (Gallus gallus)
REACT:R-CFA-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Canis familiaris)
RHEA:62403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-ephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
RHEA:44250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-DDI-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Dictyostelium discoideum)
REACT:R-HSA-417890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y5 receptor can bind to LPA (Homo sapiens)
RHEA:71614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + malonate(out) <=> (S)-malate(out) + malonate(in)
REACT:R-DDI-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Dictyostelium discoideum)
GO:0034872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-geranyl-CoA isomerase activity
REACT:R-SPO-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Schizosaccharomyces pombe)
RHEA:38578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)
RHEA:20673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH
RHEA:68976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH
RHEA:66350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2 => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A
REACT:R-DRE-444476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPRL2 receptor binds a wide range of ligands (Danio rerio)
RHEA:19230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + an aromatic aldehyde + diphosphate + NADP(+) => an aromatic carboxylate + ATP + H(+) + NADPH
REACT:R-BTA-205319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of APS and p-KIT (Bos taurus)
REACT:R-DRE-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)
RHEA:45242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4E)-(5,6-saturated)-dienoyl-CoA => a (3E,5Z)-dienoyl-CoA
RHEA:66999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpentanoate + ATP + CoA <=> 2-methylpentanoyl-CoA + AMP + diphosphate
RHEA:51308	skos:prefLabel	"F-actin monooxygenase"
RHEA:51308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"F-actin monooxygenase"
RHEA:51308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)
REACT:R-CFA-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Canis familiaris)
REACT:R-DRE-9627089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP9 is phosphorylated at T125 (Danio rerio)
RHEA:43966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA
RHEA:62182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + viteagnusin D => H2O + peregrinol diphosphate
REACT:R-GGA-2132221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) (Gallus gallus)
RHEA:10113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + L-serine => H2O + L,L-cystathionine
RHEA:13171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate => maleate
REACT:R-DDI-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)
REACT:R-DRE-8964241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta-gamma complex and PIP3 recruit BTK to membrane (Danio rerio)
REACT:R-RNO-4719423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO3 (Rattus norvegicus)
REACT:R-RNO-444654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled bile acid receptor binds lithocholic acid (Rattus norvegicus)
REACT:R-XTR-1676005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Xenopus tropicalis)
REACT:R-DRE-6786058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL4-bound IL4R1 (Danio rerio)
GO:0047725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inulosucrase activity
GO:0047725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose 1-fructosyl transferase activity
GO:0047725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity
GO:0047725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose 1-fructosyltransferase activity
RHEA:49276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + phytyl phosphate = CDP + phytyl diphosphate
REACT:R-XTR-372819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Xenopus tropicalis)
REACT:R-BTA-6804242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the complex of JMY, EP300 and TTC5 (Bos taurus)
RHEA:47593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) => CMP + ganglioside GP1c (d18:1(4E)) + H(+)
GO:0050414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formimidoylaspartate deiminase activity
GO:0050414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formiminoaspartate deiminase activity
GO:0050414	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-formimidoyl-L-aspartate iminohydrolase activity
GO:0102833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity
REACT:R-PFA-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Plasmodium falciparum)
RHEA:10709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glucose
REACT:R-CFA-5218645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 binds p-Y397-PTK2 (Canis familiaris)
RHEA:34291	skos:prefLabel	"chalcone 4'-O-glucosyltransferase"
RHEA:34291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chalcone 4'-O-glucosyltransferase"
RHEA:34291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose = 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP
RHEA:34291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose = 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP
RHEA:34291	skos:altLabel	"4'CGT"
REACT:R-MMU-9626928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP binds FOXO1 (Mus musculus)
REACT:R-XTR-5682586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 and PIAS4 are recruited to DNA DSBs (Xenopus tropicalis)
REACT:R-HSA-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Homo sapiens)
GO:0004951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCK receptor activity
GO:0004951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholecystokinin receptor activity
RHEA:33307	skos:altLabel	"2-O-alpha-mannosyl-D-glycerate PTS permease"
RHEA:33307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] = (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]
RHEA:33307	skos:prefLabel	"protein-N(pi)-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase"
RHEA:33307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase"
RHEA:56858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + AH2 + H(+) => A + an aldehyde + H2O
REACT:R-MMU-1454791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP7, MMP9 bind CD44 (Mus musculus)
REACT:R-RNO-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Rattus norvegicus)
REACT:R-RNO-351963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A18 transports Gly from extracellular region to cytosol (Rattus norvegicus)
RHEA:34308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol + NADPH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite
REACT:R-CEL-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)
REACT:R-DME-8959510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPHS2 phosphorylates H2Se to form SELP (Drosophila melanogaster)
RHEA:48661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Gallus gallus)
RHEA:49502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O
RHEA:60260	skos:prefLabel	"[histone H3]-lysine(4) N-trimethyltransferase"
RHEA:60260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine
RHEA:60260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(4) N-trimethyltransferase"
REACT:R-RNO-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Rattus norvegicus)
RHEA:61956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:34762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycerol 2-phosphate(out) + H2O <=> ADP + glycerol 2-phosphate(in) + H(+) + phosphate
REACT:R-GGA-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Gallus gallus)
REACT:R-DRE-199917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates CREB at Serine 133 (Danio rerio)
REACT:R-GGA-372705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
RHEA:36458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanylglycine(out) <=> ADP + H(+) + L-alanylglycine(in) + phosphate
REACT:R-CFA-9008692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds SMAD3 (Canis familiaris)
REACT:R-HSA-2426151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the SQLE promoter (Homo sapiens)
REACT:R-MMU-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Mus musculus)
REACT:R-XTR-5339535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTPD1 transports C1P from plasma membrane to Golgi membrane (Xenopus tropicalis)
REACT:R-DME-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Drosophila melanogaster)
REACT:R-DME-2025724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Drosophila melanogaster)
RHEA:47567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GA2 (d18:1(4E)) + H(+) + UDP
GO:0019838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neurotrophin TRK receptor activity
GO:0019838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth factor binding
RHEA:68562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-arsono-3-phospho-D-glycerate + H(+) + NADH => arsenate + D-glyceraldehyde 3-phosphate + NAD(+)
REACT:R-CFA-77585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Canis familiaris)
REACT:R-HSA-9692297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMRT1 binds the WNT4 gene (Homo sapiens)
REACT:R-SSC-450620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S193-KSRP binds 14-3-3zeta in the nucleus (Sus scrofa)
REACT:R-XTR-174209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Xenopus tropicalis)
RHEA:15617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(3+) + Fe(II)-[cytochrome c] = Fe(2+) + Fe(III)-[cytochrome c]
RHEA:15617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"iron--cytochrome-c reductase"
RHEA:15617	skos:prefLabel	"iron--cytochrome-c reductase"
REACT:R-SPO-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Schizosaccharomyces pombe)
GO:0047027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl-2-methyl-hydroxybutyrate dehydrogenase activity
GO:0047027	skos:prefLabel	"benzyl-2-methyl-hydroxybutyrate dehydrogenase"
GO:0047027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity
GO:0047027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzyl-2-methyl-hydroxybutyrate dehydrogenase"
GO:0047027	skos:altLabel	"benzyl 2-methyl-3-hydroxybutyrate dehydrogenase"
GO:0047027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH
GO:0047027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity
RHEA:65021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-ornithine
RHEA:14020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-nicotinamide D-riboside <=> ADP + beta-nicotinamide D-ribonucleotide + H(+)
REACT:R-GGA-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Gallus gallus)
REACT:R-MMU-6786110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL13-bound IL13R type II (Mus musculus)
RHEA:28193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + H(+) + H2O <=> 2'-deoxyinosine + NH4(+)
RHEA:53761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholate + deoxycholoyl-CoA => allocholoyl-CoA + deoxycholate
RHEA:65645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine
REACT:R-HSA-1362465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GHR (Homo sapiens)
REACT:R-DME-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Drosophila melanogaster)
REACT:R-BTA-507719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62:MEKK3 binds to TRAF6 (Bos taurus)
RHEA:21536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylglutaconyl-CoA hydratase"
RHEA:21536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA = 3-methyl-(2E)-glutaconyl-CoA + H2O
RHEA:21536	skos:prefLabel	"methylglutaconyl-CoA hydratase"
GO:0047488	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparan sulfate lyase activity
GO:0047488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparin lyase activity
GO:0047488	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparinase activity
GO:0047488	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin eliminase activity
EC:3.4.22.58	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-5"
EC:3.4.22.58	skos:altLabel	"Ich-3"
EC:3.4.22.58	skos:altLabel	"ICH-3 protease"
EC:3.4.22.58	skos:altLabel	"ICErel-III"
EC:3.4.22.58	skos:altLabel	"CASP-5"
EC:3.4.22.58	skos:prefLabel	"caspase-5"
GO:0004958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin F receptor activity
GO:0004958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGF receptor activity
GO:0004958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGF(2-alpha) receptor activity
REACT:R-RNO-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Rattus norvegicus)
RHEA:11102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 propanal => 4-hydroxyhexan-3-one
RHEA:29238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H(+) + NADH <=> a menaquinol + NAD(+)
RHEA:68228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out)
REACT:R-CEL-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Caenorhabditis elegans)
RHEA:68211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA
REACT:R-RNO-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-BTA-432110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Bos taurus)
REACT:R-SSC-5218818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Sus scrofa)
REACT:R-HSA-9734745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ADA does not deaminate (deoxy)adenosine (Homo sapiens)
RHEA:26055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valienol-1-phosphate guanylyltransferase"
RHEA:26055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H(+) + valienol 1-phosphate = diphosphate + GDP-valienol
RHEA:26055	skos:prefLabel	"valienol-1-phosphate guanylyltransferase"
REACT:R-RNO-202237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)
REACT:R-HSA-5607723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)
GO:0047206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase activity
GO:0047206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity
GO:0047206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase"
GO:0047206	skos:altLabel	"UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase"
GO:0047206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity
GO:0047206	skos:altLabel	"uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase"
GO:0047206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity
GO:0047206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase activity
GO:0047206	skos:prefLabel	"UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase"
GO:0047206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity
GO:0047206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine
GO:0047206	skos:altLabel	"alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase"
GO:0047206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity
GO:0047206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity
REACT:R-BTA-2046239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular KSPG translocates to the lysosome for degradation (Bos taurus)
REACT:R-DRE-8854071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome-mediated degradation of PolyUb-FBXL7 (Danio rerio)
RHEA:67072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)
REACT:R-XTR-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Xenopus tropicalis)
RHEA:49551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] <=> H(+) + L-arginyl-[protein] + lactate
REACT:R-RNO-2167942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII ectodomain shedding (Rattus norvegicus)
RHEA:25936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-methylquinoline + A + H2O = 8-methylquinolin-2(1H)-one + AH2
RHEA:68508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (Z)-beta-farnesene + diphosphate
REACT:R-HSA-3595176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CHSY1 does not transfer GalNAc to chondroitin (Homo sapiens)
REACT:R-BTA-109538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Bos taurus)
GO:0140661	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	motor activity inhibitor activity
GO:0140661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal motor inhibitor activity
REACT:R-GGA-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Gallus gallus)
RHEA:55505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] => (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:51274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoyl-CoA + glycine
REACT:R-RNO-9667563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR2 bind desmopressin (Rattus norvegicus)
REACT:R-MMU-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Mus musculus)
RHEA:34453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-rhamnose => dTDP-6-deoxy-beta-L-talose
REACT:R-MMU-5685605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF7 binds SLAMF7 (Mus musculus)
RHEA:66536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cholest-4,6-dien-3-one + H2O = 25-hydroxycholest-4,6-dien-3-one + AH2
RHEA:65928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Dictyostelium discoideum)
RHEA:71904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide
RHEA:56965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate
RHEA:51689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NAD(+) => H(+) + keto-L-tagatose + NADH
REACT:R-DRE-114261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-7 by the apoptosome (Danio rerio)
REACT:R-RNO-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Rattus norvegicus)
RHEA:50705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + NAD(+) => H(+) + NADH + propanal
REACT:R-BTA-4086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO2,3 (Bos taurus)
RHEA:16231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)
REACT:R-GGA-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Gallus gallus)
REACT:R-CEL-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Caenorhabditis elegans)
REACT:R-RNO-158925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Rattus norvegicus)
REACT:R-RNO-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Rattus norvegicus)
RHEA:48763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threitol + NAD(+) <=> H(+) + L-erythrulose + NADH
REACT:R-DDI-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Dictyostelium discoideum)
RHEA:39902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetin + UDP-alpha-D-glucose <=> 7-deoxyloganin + H(+) + UDP
RHEA:43255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate
REACT:R-XTR-3928654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin internalises EPH:EFN complexes (Xenopus tropicalis)
REACT:R-HSA-3642203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants (Homo sapiens)
REACT:R-SSC-9025969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Sus scrofa)
REACT:R-XTR-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Xenopus tropicalis)
RHEA:71423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)
REACT:R-SSC-422017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase decanoylates Proghrelin (Sus scrofa)
GO:0099582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:0099582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels
RHEA:12994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:22637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + H2O => dCMP + diphosphate + H(+)
REACT:R-RNO-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Rattus norvegicus)
GO:0030549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine receptor activator activity
RHEA:30954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> alpha-eudesmol + diphosphate
RHEA:58348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate
RHEA:62198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2 Fe(III)-[cytochrome c] + propan-2-ol
RHEA:38629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA
REACT:R-SCE-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Saccharomyces cerevisiae)
EC:3.4.21.27	skos:prefLabel	"coagulation factor XIa"
EC:3.4.21.27	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coagulation factor XIa"
EC:3.4.21.27	skos:altLabel	"plasma thromboplastin antecedent"
RHEA:64706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzophenone + H(+) + NADH => diphenylmethanol + NAD(+)
REACT:R-DRE-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Danio rerio)
REACT:R-DRE-8852481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Danio rerio)
RHEA:40464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)
RHEA:22721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidyl-[protein] => ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]
GO:0033999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin B lyase activity
GO:0033999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chonB
GO:0033999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitinase B activity
GO:0033999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dermatan sulfate lyase activity
GO:0033999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ChnB
REACT:R-HSA-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Homo sapiens)
REACT:R-SCE-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Saccharomyces cerevisiae)
REACT:R-DME-1602398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Drosophila melanogaster)
EC:3.6.1.12	skos:altLabel	"dCTPase"
EC:3.6.1.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dCTP diphosphatase"
EC:3.6.1.12	skos:altLabel	"dCTP pyrophosphatase"
EC:3.6.1.12	skos:altLabel	"deoxy-CTPase"
EC:3.6.1.12	skos:prefLabel	"dCTP diphosphatase"
EC:3.6.1.12	skos:altLabel	"deoxycytidine-triphosphatase"
RHEA:32201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CEL-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Caenorhabditis elegans)
EC:1.16.9.1	skos:prefLabel	"iron:rusticyanin reductase"
EC:1.16.9.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"iron:rusticyanin reductase"
REACT:R-GGA-879594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO4C1 mediates the transport of digoxin (Gallus gallus)
REACT:R-HSA-9765952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp12 guanylates nsp7 (Homo sapiens)
REACT:R-RNO-6786095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates STAT3,STAT6 (Rattus norvegicus)
RHEA:62972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + orsellinate
REACT:R-SSC-5661125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2sR4-HIST1H4 (Sus scrofa)
RHEA:32717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CO2 + NADH => (2R,3S)-3-methylmalate + NAD(+)
REACT:R-BTA-352119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Bos taurus)
REACT:R-HSA-5649726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)
RHEA:42615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + (n+1) H(+)(in) + NADPH <=> a plastoquinol + n H(+)(out) + NADP(+)
RHEA:38503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
REACT:R-RNO-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)
RHEA:19707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + NADH => CoA + hexadecanal + NAD(+)
REACT:R-HSA-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Homo sapiens)
REACT:R-DRE-388468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR1A,B (Danio rerio)
RHEA:23434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-70333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KHK dimer phosphorylates Fru to Fru 1-P (Canis familiaris)
RHEA:66305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide
REACT:R-DRE-111237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR1 homodimer (Danio rerio)
RHEA:15850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-ascorbate => 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate
RHEA:29412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate(in) + H(+)(in) => glycolate(out) + H(+)(out)
RHEA:15469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
RHEA:15469	skos:altLabel	"N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase"
RHEA:15469	skos:prefLabel	"1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase"
RHEA:15469	skos:altLabel	"phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase"
RHEA:15469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase"
REACT:R-SSC-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Sus scrofa)
REACT:R-SCE-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Saccharomyces cerevisiae)
RHEA:48598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoate + decanoylglycerol + H(+) => 1,2-didecanoylglycerol + H2O
REACT:R-MMU-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Mus musculus)
REACT:R-MMU-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Mus musculus)
RHEA:36292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine
RHEA:53753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP
RHEA:37306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-asparagine(out) + H2O <=> ADP + glycyl-L-asparagine(in) + H(+) + phosphate
REACT:R-GGA-421218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate (Gallus gallus)
RHEA:16663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxy-5'-fluoroadenosine + L-methionine => fluoride + S-adenosyl-L-methionine
REACT:R-DRE-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Danio rerio)
RHEA:49313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans,4-trans-xanthoxin + NAD(+) => 2-trans-(+)-abscisic aldehyde + H(+) + NADH
REACT:R-HSA-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Homo sapiens)
REACT:R-CEL-1592316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP1 (Caenorhabditis elegans)
REACT:R-RNO-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Rattus norvegicus)
REACT:R-HSA-2408542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)
GO:0098627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein arginine phosphatase activity
GO:0098627	skos:prefLabel	"protein arginine phosphatase"
GO:0098627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein arginine phosphatase"
GO:0098627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-phospho-L-arginyl-[protein] = L-arginyl-[protein] + phosphate
RHEA:20059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NH4(+) + sarcosine => 2 H(+) + H2O + N-carbamoylsarcosine
REACT:R-DRE-2730900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to pUb-TRAF6 (Danio rerio)
RHEA:61869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate
REACT:R-CFA-1482887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)
RHEA:52203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aci-nitro-2-(phenyl)ethane + glutathione <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O
RHEA:71192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid(in) + L-kynurenine(out) => an L-alpha-amino acid(out) + L-kynurenine(in)
RHEA:14914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + thymidine => adenosine + dTMP
GO:0004808	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity
GO:0004808	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity
GO:0004808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO:0004808	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity
RHEA:23802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + methanethiol + NH4(+) => H2O + L-methionine
REACT:R-HSA-3244647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGAS binds cytosolic DNA (Homo sapiens)
RHEA:22431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 <=> 2 H2O + isopenicillin N
REACT:R-DRE-9674127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Danio rerio)
EC:3.4.21.114	skos:altLabel	"3C-like Ser protease"
EC:3.4.21.114	skos:altLabel	"equine arteritis virus serine peptidase"
EC:3.4.21.114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"equine arterivirus serine peptidase"
EC:3.4.21.114	skos:altLabel	"non-structural protein 4 serine protease"
EC:3.4.21.114	skos:altLabel	"chymotrypsin-like serine proteinase nsp4"
EC:3.4.21.114	skos:altLabel	"arterivirus NSP4"
EC:3.4.21.114	skos:altLabel	"3CLSP"
EC:3.4.21.114	skos:altLabel	"3C-like serine protease"
EC:3.4.21.114	skos:prefLabel	"equine arterivirus serine peptidase"
REACT:R-HSA-5246696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC truncation mutants are not K63 polyubiquitinated (Homo sapiens)
RHEA:36832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 caldariellaquinol + n H(+)(in) + O2 => 2 caldariellaquinone + n H(+)(out) + 2 H2O
REACT:R-BTA-9734535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Bos taurus)
GO:0102210	skos:prefLabel	"rhamnogalacturonan endolyase"
GO:0102210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnogalacturonan endolyase"
GO:0102210	skos:altLabel	"alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase"
GO:0102210	skos:altLabel	"RG-lyase"
GO:0102210	skos:altLabel	"rhamnogalacturonase B"
GO:0102210	skos:altLabel	"Rgase B"
GO:0102210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnogalacturonan endolyase activity
REACT:R-CFA-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Canis familiaris)
REACT:R-SPO-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Schizosaccharomyces pombe)
REACT:R-DRE-1299359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TALK (Danio rerio)
REACT:R-CFA-1678981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR9 processing at neutral pH (Canis familiaris)
GO:0015351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin secondary active transmembrane transporter activity
GO:0015351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bilitranslocase
GO:0015351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bilirubin porter activity
REACT:R-MMU-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Mus musculus)
RHEA:55386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate
RHEA:59087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)
RHEA:57130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => H2O + 2 oxidized [azurin] + tyramine
REACT:R-HSA-2065550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds Importin beta-1 (Homo sapiens)
REACT:R-HSA-976723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serum amyloid P-component forms homopentamers (Homo sapiens)
REACT:R-BTA-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
RHEA:38065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA
REACT:R-XTR-4655355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Xenopus tropicalis)
REACT:R-CEL-9617927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO4 binds ATXN3 (Caenorhabditis elegans)
REACT:R-XTR-8848818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CBL (Xenopus tropicalis)
REACT:R-BTA-2172678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates histone H4K20me1 (Bos taurus)
RHEA:23149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + propanoate => ADP + propanoyl phosphate
REACT:R-BTA-8952807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dissociates after IL12:IL12R interaction (Bos taurus)
RHEA:54231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine
REACT:R-SPO-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Schizosaccharomyces pombe)
REACT:R-GGA-446200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLPP1 dephosphorylates DOLDP to DOLP (Gallus gallus)
RHEA:47351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a butanoate ester + H2O <=> an aliphatic alcohol + butanoate + H(+)
REACT:R-GGA-5693574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Gallus gallus)
REACT:R-BTA-2984258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 phosphorylates NEK6/NEK7 (Bos taurus)
REACT:R-HSA-164503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	First strand transfer mediated by Repeated (R) sequence (Homo sapiens)
REACT:R-HSA-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Homo sapiens)
REACT:R-DRE-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Danio rerio)
REACT:R-GGA-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Gallus gallus)
REACT:R-MMU-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Mus musculus)
REACT:R-DME-5654404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds SHC1 (Drosophila melanogaster)
GO:0047085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetonitrile monooxygenase activity
GO:0047085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating)
GO:0047085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyphenylacetonitrile 2-monooxygenase activity
GO:0047085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetonitrile hydroxylase activity
REACT:R-XTR-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Xenopus tropicalis)
REACT:R-MMU-380272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plk1-mediated phosphorylation of Nlp (Mus musculus)
REACT:R-HSA-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Homo sapiens)
REACT:R-MMU-201443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II receptor phosphorylates type I receptor (Mus musculus)
REACT:R-CFA-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
RHEA:59390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + an aliphatic alcohol + H(+) => a fatty acid ester + H2O
RHEA:12137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH
RHEA:52344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-RNO-6805285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates TP53 (Rattus norvegicus)
RHEA:46991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2
RHEA:64566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ilicicolin H => 8-epi-ilicicolin H
REACT:R-SPO-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Schizosaccharomyces pombe)
REACT:R-HSA-391943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLT2 binds LTC4,LTD4,LTE4 (Homo sapiens)
REACT:R-SSC-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Sus scrofa)
REACT:R-BTA-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Bos taurus)
REACT:R-MMU-6810392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMEM55B translocates to the nucleus (Mus musculus)
RHEA:26453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NADP(+) + succinate semialdehyde <=> H(+) + NADPH + succinyl-CoA
RHEA:32475	skos:altLabel	"GSDMT"
RHEA:32475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine/sarcosine/dimethylglycine N-methyltransferase"
RHEA:32475	skos:prefLabel	"glycine/sarcosine/dimethylglycine N-methyltransferase"
RHEA:32475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + 3 S-adenosyl-L-methionine = glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine
RHEA:32475	skos:altLabel	"glycine sarcosine dimethylglycine N-methyltransferase"
REACT:R-DRE-8847875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF1:GTP binds Golgin TRIP11 (Danio rerio)
RHEA:50685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-phenyl-L-glutamine => aniline + H(+) + L-glutamate
GO:0019119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene-9,10-epoxide hydrolase activity
RHEA:12920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha(S)-strictosidine + H2O <=> D-glucose + strictosidine aglycone
RHEA:57846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form) => fraxetin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SCE-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Saccharomyces cerevisiae)
RHEA:60632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH
REACT:R-CFA-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
REACT:R-GGA-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Gallus gallus)
REACT:R-RNO-75872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Rattus norvegicus)
REACT:R-DME-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Drosophila melanogaster)
REACT:R-RNO-1482543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Rattus norvegicus)
RHEA:55058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-DME-1855208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Drosophila melanogaster)
RHEA:10993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + NADP(+) => glyoxylate + H(+) + NADPH
RHEA:43096	skos:prefLabel	"23S rRNA (guanine(2535)-N(1))-methyltransferase"
RHEA:43096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (guanine(2535)-N(1))-methyltransferase"
RHEA:43096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-DME-209370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CI75 transports from the cytosol to the nucleus (Drosophila melanogaster)
REACT:R-SSC-192335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Sus scrofa)
REACT:R-RNO-141200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates of PEA (Rattus norvegicus)
RHEA:35546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphooxypyruvate + H2O <=> 3-hydroxypyruvate + phosphate
RHEA:36158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + Co(II)-factor III + S-adenosyl-L-methionine <=> A + Co-precorrin-4 + S-adenosyl-L-homocysteine
RHEA:42949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(48) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:30991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Homo sapiens)
RHEA:35579	skos:prefLabel	"sinapoyl-beta-D-glucose:anthocyanin sinapoyltransferase"
RHEA:35579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sinapoyl-beta-D-glucose:anthocyanin sinapoyltransferase"
RHEA:35579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 = anthocyanin A11 + D-glucose
RHEA:44259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:38808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:61631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanal <=> 1-piperideine + H2O
RHEA:55189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyluridine(54) in tRNA + ATP + hydrogen sulfide => 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate
REACT:R-HSA-5666049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it (Homo sapiens)
REACT:R-SSC-391378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follicle-stimulating hormone receptor can bind FSH (Sus scrofa)
REACT:R-SSC-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Sus scrofa)
REACT:R-MMU-4551649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO1 (Mus musculus)
RHEA:14024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ecdysone + O2 <=> 20-hydroxyecdysone + A + H2O
RHEA:63494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menadiol + NADP(+) => H(+) + menadione + NADPH
REACT:R-DRE-177922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR dimerization (Danio rerio)
GO:0036423	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hexaprenyl pyrophosphate synthetase activity
GO:0036423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity
GO:0036423	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hexaprenyl diphosphate synthase activity
REACT:R-HSA-9684033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)
REACT:R-HSA-8852522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 dimer:MST1R dimer binds MST1R dimer (Homo sapiens)
REACT:R-MMU-5684887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of CHEK1 at resected DNA DSBs (Mus musculus)
REACT:R-PFA-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Plasmodium falciparum)
REACT:R-XTR-9023632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Xenopus tropicalis)
REACT:R-CEL-8936851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHRR binds ARNT (Caenorhabditis elegans)
REACT:R-BTA-3134800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING dimerization (Bos taurus)
REACT:R-XTR-212710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR activates PLC-gamma1 by phosphorylation (Xenopus tropicalis)
REACT:R-GGA-2534248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP2, MMP3, MMP7 (Gallus gallus)
REACT:R-SCE-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Saccharomyces cerevisiae)
RHEA:69721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-AMP + diphosphate => (indol-3-yl)acetate + ATP + H(+)
REACT:R-CFA-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Canis familiaris)
REACT:R-SSC-201648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, Endofin, recruits R-Smad1/5/8 (Sus scrofa)
REACT:R-BTA-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Bos taurus)
GO:0140346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylserine flippase activity (exoplasmic to cytosolic leaftlet)
GO:0140346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylserine flippase activity
REACT:R-RNO-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Rattus norvegicus)
GO:0047440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity
GO:0047440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-pentonate aldolase activity
GO:0047440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-D-pentonate aldolase activity
GO:0047440	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-deoxy-D-pentulosonic acid aldolase
REACT:R-MMU-1306957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
REACT:R-RNO-9652580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Rattus norvegicus)
RHEA:31750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH
RHEA:34388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP
REACT:R-XTR-2046084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Xenopus tropicalis)
REACT:R-XTR-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Xenopus tropicalis)
GO:0047647	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity
GO:0047647	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity
GO:0047647	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylacetylglycerophosphate phosphatase activity
GO:0047647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylacetylglycerophosphatase activity
REACT:R-BTA-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Bos taurus)
REACT:R-BTA-5218916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPK2/3 phosphorylates HSP27 (Bos taurus)
RHEA:36422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Sus scrofa)
REACT:R-SSC-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Sus scrofa)
RHEA:71891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide
REACT:R-MMU-6807055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR7 reduces 7-dehydroCHOL to CHOL (Mus musculus)
RHEA:70998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine(out) + L-glutamate(in) <=> L-cystine(in) + L-glutamate(out)
GO:0047365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 3'-sulfotransferase activity
GO:0047365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin-3-sulphate 3'-sulphotransferase activity
GO:0047365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-sulfotransferase activity
GO:0047365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS:flavonol 3-sulfate 3'-sulfotransferase activity
GO:0047365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity
GO:0047365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin-3-sulfate 3'-sulfotransferase activity
REACT:R-SCE-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Saccharomyces cerevisiae)
RHEA:29061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + ubiquinol-8 => 2 H(+)(in) + H2 + ubiquinone-8
RHEA:47781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 25S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine
GO:0036318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide pheromone receptor activity
RHEA:28146	skos:altLabel	"GHQ 3''-hydroxylase"
RHEA:28146	skos:prefLabel	"geranylhydroquinone 3''-hydroxylase"
RHEA:28146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranylhydroquinone 3''-hydroxylase"
RHEA:28146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] = 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28146	skos:altLabel	"CYP76B74"
REACT:R-CFA-392263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR2 (Canis familiaris)
REACT:R-BTA-6798528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Mn2+ (Bos taurus)
REACT:R-GGA-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Gallus gallus)
REACT:R-CFA-6786171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 deubiquitination by USP1:WDR48 (Canis familiaris)
REACT:R-DRE-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Danio rerio)
RHEA:46202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Mus musculus)
REACT:R-CEL-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
GO:0102640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	paspalinine synthase activity
RHEA:17170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-D-galactosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate
REACT:R-CFA-450595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR:mRNA complex translocates from the nucleus to the cytosol (Canis familiaris)
RHEA:26523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2-methylcitrate => 2-methyl-trans-aconitate + H2O
REACT:R-MMU-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Mus musculus)
REACT:R-HSA-76434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)
RHEA:36799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate
GO:0035642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H3-R17 specific)
GO:0035642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3R17 methyltransferase activity
GO:0035642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R17 methyltransferase activity
GO:0035642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-R17 specific)
GO:0035642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine N-methyltransferase activity (H3-R17 specific)
RHEA:10903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic L-alpha-amino acid + glyoxylate <=> an aromatic oxo-acid + glycine
RHEA:20971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O
REACT:R-HSA-193682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)
RHEA:68314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O
RHEA:42862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycerol + phosphate => 1,2-dioctanoyl-sn-glycero-3-phosphate + H2O
REACT:R-XTR-5602295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F22 20-hydroxylates TrXA3 (Xenopus tropicalis)
REACT:R-DDI-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Dictyostelium discoideum)
REACT:R-BTA-9706399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 hydrolyzes ATP (Bos taurus)
REACT:R-CFA-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)
REACT:R-DRE-6790487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 ubiquitinates SUMOylated XPC (Danio rerio)
RHEA:28376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
REACT:R-SPO-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Schizosaccharomyces pombe)
REACT:R-GGA-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Gallus gallus)
REACT:R-MMU-1592240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NRF2 (Mus musculus)
REACT:R-SSC-6805285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates TP53 (Sus scrofa)
RHEA:16771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate
RHEA:53638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine
GO:0140315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron ion sequestering activity
GO:0033963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ChEH
GO:0033963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol-epoxide hydrolase activity
GO:0033963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol-5,6-oxide hydrolase activity
GO:0033963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity
RHEA:33138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(in) + Na(+)(in) <=> malonate(out) + Na(+)(out)
RHEA:46443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 <=> A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O
REACT:R-HSA-9032863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates NTRK2 (Homo sapiens)
RHEA:34199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = bracteatin 6-O-beta-glucoside + H2O
REACT:R-SPO-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Schizosaccharomyces pombe)
REACT:R-HSA-2855125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-1 binds to molecular patterns on the target cell surface (Homo sapiens)
RHEA:20793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-lysine + tRNA(Lys) => AMP + diphosphate + L-lysyl-tRNA(Lys)
RHEA:38871	skos:prefLabel	"23S rRNA pseudouridine(2457) synthase"
RHEA:38871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA pseudouridine(2457) synthase"
RHEA:38871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA
REACT:R-GGA-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Gallus gallus)
RHEA:72122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + glycine betaine(out) <=> (R)-carnitine(out) + glycine betaine(in)
REACT:R-BTA-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Bos taurus)
RHEA:20500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-arylethylamine + acetyl-CoA <=> CoA + H(+) + N-acetyl-2-arylethylamine
RHEA:72820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)
REACT:R-RNO-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Rattus norvegicus)
REACT:R-RNO-8984014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Rattus norvegicus)
RHEA:12664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + hexadecanoyl-CoA <=> CoA + O-hexadecanoyl-(R)-carnitine
REACT:R-CEL-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Caenorhabditis elegans)
REACT:R-DRE-174445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap on the C-strand (Danio rerio)
REACT:R-RNO-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Rattus norvegicus)
REACT:R-XTR-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Xenopus tropicalis)
GO:0031894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	V1A vasopressin receptor binding
GO:0031894	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	V1A vasopressin receptor ligand
REACT:R-DDI-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Dictyostelium discoideum)
RHEA:47711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-glucose 1-phosphate + H(+) <=> ADP-alpha-D-glucose + phosphate
REACT:R-HSA-6803233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RHEA:62736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate
REACT:R-XTR-9018863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Xenopus tropicalis)
GO:0030613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on phosphorus or arsenic in donors
GO:0030613	skos:prefLabel	"Acting on phosphorus or arsenic in donors"
GO:0030613	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors
GO:0030613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on phosphorus or arsenic in donors"
REACT:R-XTR-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Xenopus tropicalis)
RHEA:35862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-DRE-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Danio rerio)
REACT:R-CFA-377644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of CSK from SRC (Canis familiaris)
REACT:R-SSC-5662606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds zinc (Sus scrofa)
REACT:R-MMU-2473151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister centromeres (Mus musculus)
REACT:R-GGA-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Gallus gallus)
RHEA:37796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADPH + O2 => 2 H2O + 2 NADP(+)
REACT:R-HSA-3371518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 binds to HSF1 (Homo sapiens)
REACT:R-BTA-9026777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Bos taurus)
REACT:R-BTA-193497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Bos taurus)
RHEA:54975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]
RHEA:71264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-proline(out) + 2 Na(+)(out) => chloride(in) + L-proline(in) + 2 Na(+)(in)
RHEA:47514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
REACT:R-GGA-445113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Urotensin-2 receptor binds urotensin-2 and 2B (Gallus gallus)
REACT:R-RNO-195251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the destruction complex (Rattus norvegicus)
REACT:R-MMU-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Mus musculus)
RHEA:34879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + methyl 3-cyano-2-phenylpropanoate = 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)
REACT:R-XTR-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Xenopus tropicalis)
REACT:R-RNO-8862733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR2, CCR3 bind CCL13 (Rattus norvegicus)
RHEA:50852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
RHEA:45738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA => (3E)-hexenoyl-CoA
RHEA:29770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-methionine(out) + H2O <=> ADP + D-methionine(in) + H(+) + phosphate
RHEA:40987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethylenediaminetetraacetate monooxygenase"
RHEA:40987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDTA + 2 FMNH2 + 2 O2 = ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O
RHEA:40987	skos:prefLabel	"ethylenediaminetetraacetate monooxygenase"
RHEA:54630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + dodecanoyl-CoA + O2
RHEA:56225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP
REACT:R-CEL-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)
REACT:R-HSA-157926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 traffics to nucleus (Homo sapiens)
REACT:R-MMU-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Mus musculus)
GO:0047559	skos:prefLabel	"3-dehydro-L-gulonate 2-dehydrogenase"
GO:0047559	skos:altLabel	"3-keto-L-gulonate dehydrogenase"
GO:0047559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity
GO:0047559	skos:altLabel	"2,3-diketo-L-gulonate reductase"
GO:0047559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate 2-dehydrogenase activity
GO:0047559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydro-L-gulonate 2-dehydrogenase"
GO:0047559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-diketo-L-gulonate reductase activity
GO:0047559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-keto-L-gulonate dehydrogenase activity
GO:0047559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketogulonate dehydrogenase activity
REACT:R-DRE-202704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaXbeta2 binds JAM3 (Danio rerio)
REACT:R-DRE-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Danio rerio)
REACT:R-MMU-1602458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP10 (Mus musculus)
REACT:R-DRE-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Danio rerio)
GO:1901612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cardiolipin binding
REACT:R-DDI-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Dictyostelium discoideum)
RHEA:39779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-416929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PGF2a (Danio rerio)
REACT:R-HSA-6787757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates acidic AAs (Homo sapiens)
REACT:R-CEL-159566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Caenorhabditis elegans)
REACT:R-BTA-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Bos taurus)
REACT:R-BTA-8869667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxLDL:CD36 binds TLR4:TLR6 (Bos taurus)
REACT:R-HSA-448741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22RA2 binds IL22 (Homo sapiens)
RHEA:15547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + pyruvate => (3S)-citramalate
RHEA:40551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethylphylloquinol methyltransferase"
RHEA:40551	skos:altLabel	"2-phytyl-1,4-naphthoquinol methyltransferase"
RHEA:40551	skos:prefLabel	"demethylphylloquinol methyltransferase"
RHEA:40551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylphylloquinol + S-adenosyl-L-methionine = H(+) + phylloquinol + S-adenosyl-L-homocysteine
REACT:R-RNO-374664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of Ezrin (Rattus norvegicus)
REACT:R-GGA-429581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 transports vitamins from extracellular region to cytosol (Gallus gallus)
REACT:R-RNO-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Rattus norvegicus)
RHEA:25786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + pyruvate => 2-dehydro-3-deoxy-L-rhamnonate
REACT:R-HSA-9021450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes (Homo sapiens)
REACT:R-HSA-5634729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)
RHEA:59077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)
REACT:R-CFA-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Canis familiaris)
REACT:R-GGA-417896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y6 receptor can bind to UDP (Gallus gallus)
REACT:R-SPO-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Schizosaccharomyces pombe)
REACT:R-HSA-77345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Homo sapiens)
REACT:R-SSC-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Sus scrofa)
REACT:R-HSA-9619467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1F dephosphorylates CAMK1 (Homo sapiens)
GO:0099507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential
GO:0099507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential
GO:0099507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential
GO:0099507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
GO:0099507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand gated ion channel activity involved in regulation of presynaptic membrane potential
REACT:R-RNO-2424243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Rattus norvegicus)
REACT:R-PFA-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Plasmodium falciparum)
RHEA:70895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-cysteinyl-[protein] + O2 = H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]
REACT:R-HSA-2399999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates RSK (Homo sapiens)
RHEA:10200	skos:prefLabel	"2-enoate reductase"
RHEA:10200	skos:altLabel	"enoate reductase"
RHEA:10200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate + NAD(+) = (2E)-2-butenoate + H(+) + NADH
RHEA:10200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-enoate reductase"
RHEA:63793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate
RHEA:30151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + NADP(+) = FAD + 2 H(+) + NADPH
RHEA:68790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-gamma-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate
RHEA:50090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Drosophila melanogaster)
REACT:R-HSA-2023455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c P252X mutant dimers (Homo sapiens)
GO:0047453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)
GO:0047453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)
GO:0047453	skos:prefLabel	"ATP-dependent NAD(P)H-hydrate dehydratase"
GO:0047453	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	reduced nicotinamide adenine dinucleotide hydrate dehydratase activity
GO:0047453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent H4NAD(P)OH dehydratase activity
GO:0047453	skos:altLabel	"ATP-dependent H4NAD(P)OH dehydratase"
GO:0047453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent NAD(P)H-hydrate dehydratase activity
GO:0047453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ATP-dependent NAD(P)H-hydrate dehydratase"
GO:0047453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent H(4)NAD(P)OH dehydratase activity
GO:0047453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate
GO:0047453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate
REACT:R-XTR-9614564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO4 (Xenopus tropicalis)
RHEA:72277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate(out) + sulfate(in) => oxalate(in) + sulfate(out)
RHEA:40776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-phenylacetonitrile + H(+) + 2 H2O => D-alpha-phenylglycine + NH4(+)
REACT:R-SPO-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Schizosaccharomyces pombe)
REACT:R-MMU-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Mus musculus)
EC:2.7.1.78	skos:prefLabel	"polynucleotide 5'-hydroxyl-kinase"
EC:2.7.1.78	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polynucleotide 5'-hydroxyl-kinase"
REACT:R-XTR-5617138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Xenopus tropicalis)
RHEA:17558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + malonyl-CoA => CoA + N-malonylanthranilate
REACT:R-CFA-2130486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoating of clathrin-coated vesicles and fusion with endosomes (Canis familiaris)
REACT:R-BTA-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)
REACT:R-RNO-9769235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGED1 binds NPAS4 (Rattus norvegicus)
GO:0034882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitamide amidase activity
GO:0031780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenocorticotropin hormone receptor binding
GO:0031780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin receptor binding
GO:0031780	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	adrenocorticotropic hormone receptor ligand
GO:0031780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenocorticotropin receptor binding
GO:0031780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACTH receptor binding
GO:0031780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin hormone receptor binding
REACT:R-CFA-375151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with collagens (Canis familiaris)
REACT:R-RNO-199206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Rattus norvegicus)
RHEA:12878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylacetone + O2 => acetate + H(+) + methylglyoxal
RHEA:40504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine
RHEA:68129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + phytol => a fatty acid phytyl ester + CoA
REACT:R-BTA-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Bos taurus)
REACT:R-CFA-8985900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Canis familiaris)
REACT:R-XTR-2473596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP15 (Xenopus tropicalis)
RHEA:53221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-Kdo-ase activity
GO:0050534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity
GO:0050534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyoctulosonase activity
REACT:R-HSA-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Homo sapiens)
REACT:R-SSC-5577237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNH2:KCNE transport K+ from cytosol to extracellular region (Sus scrofa)
REACT:R-MMU-8864569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds TFAP2C (Mus musculus)
REACT:R-GGA-921145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated chicken TAK1 dissociates from the activated TLR3 complex (Gallus gallus)
RHEA:32083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + pseudaminate = CMP-pseudaminate + diphosphate
RHEA:32083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudaminic acid cytidylyltransferase"
RHEA:32083	skos:prefLabel	"pseudaminic acid cytidylyltransferase"
RHEA:19384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-oxalosuccinate + H(+) <=> 2-oxoglutarate + CO2
REACT:R-SSC-174448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex on the C-strand of the telomere (Sus scrofa)
REACT:R-DRE-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Danio rerio)
REACT:R-HSA-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Homo sapiens)
REACT:R-RNO-176494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to 27HCHOL (Rattus norvegicus)
REACT:R-DME-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Drosophila melanogaster)
RHEA:65326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin B + CoA => acetyl-CoA + chrodrimanin A
RHEA:71057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(in) + L-methionine(out) => L-cysteine(out) + L-methionine(in)
REACT:R-HSA-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Homo sapiens)
REACT:R-HSA-373739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
RHEA:65076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:19646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-threo-aldose + NAD(+) => a D-threo-aldono-1,5-lactone + H(+) + NADH
REACT:R-XTR-211988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Xenopus tropicalis)
RHEA:57515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorobenzene + H(+) + NADH + O2 <=> (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)
RHEA:14118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate
RHEA:42059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + NAD(+) <=> 13-cis-retinal + H(+) + NADH
REACT:R-HSA-917839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-Transferrin dissociates from the receptor complex (Homo sapiens)
REACT:R-CEL-69600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic degradation of ubiquitinated-Cdc25A (Caenorhabditis elegans)
REACT:R-MMU-3769393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ binds p-CBY:CTNNB1 (Mus musculus)
RHEA:72861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A[3'-5']pA[3'-5']pAp[3'] + H(+) => 3',3',3'-c-tri-AMP + H2O
REACT:R-BTA-5654597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Bos taurus)
REACT:R-PFA-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)
REACT:R-HSA-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Homo sapiens)
RHEA:32390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocarveol + NAD(+) <=> dihydrocarvone + H(+) + NADH
RHEA:60030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O
RHEA:17542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic primary alcohol + O2 => an aromatic aldehyde + H2O2
RHEA:19461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)
RHEA:28309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
REACT:R-HSA-9709787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 9b binds TOMM70 (Homo sapiens)
GO:0140841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain O-GlcNAc transferase activity
RHEA:38232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA
REACT:R-HSA-167637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex (Homo sapiens)
REACT:R-BTA-5250217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP binds ARL2BP (Bos taurus)
REACT:R-MMU-1671687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR activation (Mus musculus)
RHEA:15879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate
RHEA:39318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA <=> (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O
REACT:R-RNO-177920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2 to GAB1 (Rattus norvegicus)
REACT:R-SCE-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Saccharomyces cerevisiae)
GO:0031754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edg-1 sphingosine 1-phosphate receptor binding
GO:0031754	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Edg-1 sphingosine 1-phosphate receptor ligand
RHEA:15781	skos:prefLabel	"tyrosine 2,3-aminomutase"
RHEA:15781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate
RHEA:15781	skos:altLabel	"tyrosine alpha,beta-mutase"
RHEA:15781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine 2,3-aminomutase"
REACT:R-RNO-2028294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Rattus norvegicus)
REACT:R-HSA-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Homo sapiens)
RHEA:65266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chrodrimanin C => 3-hydroxypentacecilide A + A
REACT:R-XTR-1912379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of fringe-modified NOTCH to plasma membrane (Xenopus tropicalis)
RHEA:69644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 => (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2
REACT:R-RNO-8983841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 associates with IL6ST:IL6ST (Rattus norvegicus)
RHEA:40095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxohexacosanoate + H2O + NAD(+) = 2 H(+) + hexacosanedioate + NADH
RHEA:59551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N',N''-triacetylchitotriose + O2 <=> H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone
REACT:R-HSA-194632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Homo sapiens)
REACT:R-RNO-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)
REACT:R-SSC-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Sus scrofa)
REACT:R-SSC-6784319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,TYK2 phosphorylate JAK1,TYK2 (Sus scrofa)
RHEA:26405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) = H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate
REACT:R-HSA-163539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	perilipin:CGI-58 complex -> perilipin + CGI-58 (Homo sapiens)
REACT:R-DME-390184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YKI binds to SD and activates transcription (Drosophila melanogaster)
GO:0019161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diamine aminotransferase activity
GO:0019161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diamine transaminase activity
GO:0019161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diamine:2-oxoglutarate aminotransferase activity
GO:0019161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diamine-ketoglutaric transaminase activity
GO:0019161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amine transaminase activity
GO:0019161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amine-ketoacid transaminase activity
REACT:R-HSA-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Homo sapiens)
REACT:R-MMU-8948066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-IRAK1 dissociates (Mus musculus)
RHEA:71419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) = 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)
RHEA:13747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microthecin => ascopyrone M
REACT:R-HSA-2993769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO3 from E1 to UBE2I (UBC9) (Homo sapiens)
EC:2.8.3.16	skos:altLabel	"formyl-CoA oxalate CoA-transferase"
EC:2.8.3.16	skos:prefLabel	"formyl-CoA transferase"
EC:2.8.3.16	skos:altLabel	"formyl-coenzyme A transferase"
EC:2.8.3.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formyl-CoA transferase"
EC:1.3.7.11	skos:prefLabel	"2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase"
EC:1.3.7.11	skos:altLabel	"2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor)"
EC:1.3.7.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase"
REACT:R-CFA-1236964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of peptide bound MHC class I complex to cell surface (Canis familiaris)
RHEA:12794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + ATP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP
REACT:R-CFA-199443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Canis familiaris)
REACT:R-RNO-199014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD96 binds PVR (Rattus norvegicus)
REACT:R-SSC-158747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Sus scrofa)
REACT:R-CEL-170126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin B1 in the CRS domain (Caenorhabditis elegans)
REACT:R-GGA-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Gallus gallus)
RHEA:47879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b + H2O <=> ganglioside GM1 + N-acetylneuraminate
RHEA:17674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + S-adenosyl-L-methionine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-508451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B is phosphorylated (Bos taurus)
RHEA:18954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythro-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin
RHEA:30008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-arabinose(out) => ADP + H(+) + L-arabinose(in) + phosphate
REACT:R-BTA-383373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 3 (NK3) binds to neurokinin B (Bos taurus)
REACT:R-GGA-419253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O (Gallus gallus)
RHEA:11500	skos:prefLabel	"3-deoxy-manno-octulosonate-8-phosphatase"
RHEA:11500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-manno-octulosonate-8-phosphatase"
RHEA:11500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate
REACT:R-HSA-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Homo sapiens)
RHEA:44946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-3-acyl-sn-glycerol + H2O
RHEA:38013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H(+) + phytol => chlorophyll a + H2O
REACT:R-DME-71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer reduces PYR to LACT (Drosophila melanogaster)
EC:3.1.11.4	skos:altLabel	"phage SP3 DNase"
EC:3.1.11.4	skos:prefLabel	"exodeoxyribonuclease (phage SP3-induced)"
EC:3.1.11.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exodeoxyribonuclease (phage SP3-induced)"
EC:3.1.11.4	skos:altLabel	"DNA 5'-dinucleotidohydrolase"
REACT:R-HSA-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Homo sapiens)
RHEA:20704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+)
RHEA:20704	skos:prefLabel	"D-amino-acid N-acetyltransferase"
RHEA:20704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-amino-acid N-acetyltransferase"
REACT:R-MMU-380303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Phospho-Nlp from the centrosome (Mus musculus)
REACT:R-XTR-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Xenopus tropicalis)
GO:0016657	skos:prefLabel	"With a nitrogenous group as acceptor"
GO:0016657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor
GO:0016657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor
GO:0016657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a nitrogenous group as acceptor"
REACT:R-XTR-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Xenopus tropicalis)
RHEA:20454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scopoletin + UDP-alpha-D-glucose => H(+) + scopolin + UDP
GO:0046980	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TAPBP binding
GO:0046980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAP binding protein binding
GO:0046980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tapasin binding
RHEA:65493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine
RHEA:29079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + ubiquinone-8 = pyruvate + ubiquinol-8
REACT:R-BTA-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Bos taurus)
REACT:R-DRE-5671772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T38-PPP1R14A binds MLCP (Danio rerio)
REACT:R-RNO-9646348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Rattus norvegicus)
RHEA:10519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) <=> (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH
RHEA:37741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine
RHEA:59530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]
GO:0015450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SodB gets secreted (Homo sapiens)
GO:0015450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-transporting ATPase activity
GO:0015450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein translocase activity
GO:0015450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO:0018237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urease activator activity
GO:0018237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urease activase activity
REACT:R-BTA-8853405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 binds AURKA at centrosomes (Bos taurus)
REACT:R-SSC-199093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXADR binds to AMICA1 (Sus scrofa)
RHEA:19372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-RNO-2424477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS mediated nucleotide exchange of RAS (SHC) (Rattus norvegicus)
REACT:R-DRE-5666129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP recruits DIAPH2-2 to kinetochores (Danio rerio)
REACT:R-GGA-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Gallus gallus)
RHEA:23870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + cyclohexanone => (1-hydroxycyclohexan-1-yl)acetyl-CoA
REACT:R-DRE-1236941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of receptor bound antigen into clathrin coted vesicles (Danio rerio)
REACT:R-SSC-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Sus scrofa)
RHEA:72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(in) + H(+)(out) = estrone 3-sulfate(out) + H(+)(in)
RHEA:52356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate
RHEA:33774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)
REACT:R-GGA-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Gallus gallus)
RHEA:69888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + uridine(out) => Na(+)(in) + uridine(in)
REACT:R-CEL-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Caenorhabditis elegans)
RHEA:62647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z)-eicosadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-eicosadienoate
REACT:R-SSC-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Sus scrofa)
REACT:R-DME-5694442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH2,3 bind GRIA1 (Drosophila melanogaster)
RHEA:69820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hypotaurine + NADPH + O2 => H2O + NADP(+) + taurine
GO:0140864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone ubiquitin ligase activity (H2A-K129 specific)
GO:0140864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AK129 ubiquitin ligase activity
GO:0140864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A-K129 ubiquitin ligase activity
REACT:R-MMU-9709883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB scavenges O2.- (Mus musculus)
RHEA:70768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-2731074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Canis familiaris)
REACT:R-RNO-1454791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP7, MMP9 bind CD44 (Rattus norvegicus)
REACT:R-MMU-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Mus musculus)
REACT:R-CFA-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Canis familiaris)
RHEA:56409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-DRE-937337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Danio rerio)
REACT:R-HSA-9754978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates RBV-MP (Homo sapiens)
RHEA:55140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)
RHEA:20781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GMP => ADP + GDP
REACT:R-SPO-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Schizosaccharomyces pombe)
REACT:R-SSC-2671885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers:H+ transport extracellular Na+ to cytosol (Sus scrofa)
RHEA:14047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(hydrohydroxyphosphoryl)pyruvate + CO2 => 1-carboxyvinyl carboxyphosphonate + H(+)
RHEA:70112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-202466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Bcl10 to CARMA1 (Homo sapiens)
REACT:R-XTR-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Xenopus tropicalis)
RHEA:29014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + H(+)(in) <=> 2-oxoglutarate(out) + H(+)(out)
GO:0160004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly-ADP-D-ribose modification-dependent protein binding
RHEA:18386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + 2 ATP + 3 H2O + hydrogencarbonate => acetoacetate + 2 AMP + 4 H(+) + 4 phosphate
REACT:R-RNO-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)
RHEA:24984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:24736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde => 2-oxoglutarate + 4-hydroxybutanoate
RHEA:52868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:12951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-fuconate + H2O => D-fuconate
RHEA:42871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norspermine + S-adenosyl 3-(methylsulfanyl)propylamine <=> caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine
RHEA:14219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]
REACT:R-SSC-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Sus scrofa)
REACT:R-CEL-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Caenorhabditis elegans)
REACT:R-HSA-9617326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)
RHEA:55997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
RHEA:24676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CMP + H(+) => ATP + cytidine
GO:0018473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
RHEA:69415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + tert-butyl hydroperoxide <=> glutathione disulfide + H2O + tert-butanol
REACT:R-XTR-3788745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL8 promoter (Xenopus tropicalis)
REACT:R-RNO-390912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds hist (Rattus norvegicus)
REACT:R-SSC-8878220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the NOTCH1 coactivator complex (Sus scrofa)
RHEA:63584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxyecdysone 22-phosphate + H2O = 2-deoxyecdysone + phosphate
REACT:R-PFA-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-SSC-1889978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALT6 transfers Gal to the tetrasaccharide linker (Sus scrofa)
REACT:R-CEL-5675431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates RAF1 (Caenorhabditis elegans)
REACT:R-HSA-9694390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp15 binds RB1 (Homo sapiens)
REACT:R-CFA-209973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is diiodinated (Canis familiaris)
RHEA:70201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroxyindole => dopaminechrome
REACT:R-HSA-420598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:Nectin-4 trans heterodimer formation (Homo sapiens)
REACT:R-HSA-5656064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FLRT1,2,3 (Homo sapiens)
RHEA:43767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + chenodeoxycholate + CoA <=> AMP + chenodeoxycholoyl-CoA + diphosphate
REACT:R-HSA-9684352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3-4 cleaves itself (Homo sapiens)
REACT:R-HSA-8858252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDLBP binds HDL (Homo sapiens)
REACT:R-CEL-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Caenorhabditis elegans)
RHEA:68267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formaldehyde
REACT:R-SCE-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Saccharomyces cerevisiae)
REACT:R-DME-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Drosophila melanogaster)
REACT:R-DME-2046239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular KSPG translocates to the lysosome for degradation (Drosophila melanogaster)
RHEA:38733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol
REACT:R-CFA-5668714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX1 complex (Canis familiaris)
REACT:R-HSA-5661184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)
REACT:R-SSC-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Sus scrofa)
REACT:R-RNO-8852354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 facilitates proteasome-mediated degradation of TP53 (Rattus norvegicus)
REACT:R-BTA-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Bos taurus)
REACT:R-SSC-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Sus scrofa)
GO:0008929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylglyoxal synthetase activity
GO:0008929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerone-phosphate phospho-lyase activity
GO:0008929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerone-phosphate phospho-lyase (methylglyoxal-forming)
GO:0008929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylglyoxal synthase activity
REACT:R-SCE-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Saccharomyces cerevisiae)
REACT:R-SSC-9686980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 recruits APC/C:Cdh1 complex to SKP2 (Sus scrofa)
GO:0098973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of postsynaptic actin cytoskeleton
RHEA:52604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP = 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)
GO:0018775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HMSH
GO:0018775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxymuconate-semialdehyde formylhydrolase activity
GO:0018775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxymuconic semialdehyde hydrolase activity
GO:0018775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxymuconate-semialdehyde hydrolase activity
GO:0018775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HOD hydrolase activity
REACT:R-SSC-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Sus scrofa)
REACT:R-DME-5577234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Drosophila melanogaster)
REACT:R-GGA-2395340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxyallysine by LOX (Gallus gallus)
RHEA:64721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + pyruvate(out) => H(+)(in) + pyruvate(in)
REACT:R-RNO-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Rattus norvegicus)
REACT:R-CEL-192056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Caenorhabditis elegans)
REACT:R-XTR-983696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Immunoglobulin of the BCR binds antigen (Xenopus tropicalis)
RHEA:11991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine
RHEA:48699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol
RHEA:62908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nor-toralactone + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toralactone
RHEA:45038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide => 3 Fe(III)-[cytochrome c] + hydroxylamine
REACT:R-DME-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Drosophila melanogaster)
REACT:R-MMU-9634846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNTL (BMAL1) (Mus musculus)
REACT:R-DRE-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Danio rerio)
REACT:R-CFA-6799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates TP53 (Canis familiaris)
REACT:R-DRE-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Danio rerio)
REACT:R-DRE-5683405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP5C dephosphorylates TP53BP1 (Danio rerio)
REACT:R-HSA-2395412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SYK (Homo sapiens)
REACT:R-XTR-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Xenopus tropicalis)
REACT:R-DRE-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Danio rerio)
RHEA:30810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH
REACT:R-MMU-6809320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Mus musculus)
REACT:R-XTR-191656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Closure of gap junction (Xenopus tropicalis)
RHEA:55107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoheptanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyheptanoyl-[ACP] + NADP(+)
REACT:R-SPO-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Schizosaccharomyces pombe)
RHEA:19506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose => (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP
RHEA:70095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-methyl-tetronate + o-quinone methide = peniphenone D
REACT:R-DME-1963589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Drosophila melanogaster)
RHEA:29312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + O2 + sulfoacetate => FMN + glyoxylate + 2 H(+) + H2O + sulfite
RHEA:49746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + deoxyviolacein + H2O => deoxyviolaceinate + H(+) + O2
REACT:R-CFA-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
REACT:R-XTR-982807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation of GHR (Xenopus tropicalis)
RHEA:72818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)
REACT:R-CEL-374701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DCC by Fyn (Caenorhabditis elegans)
RHEA:14181	skos:altLabel	"TMLD"
RHEA:14181	skos:altLabel	"TML hydroxylase"
RHEA:14181	skos:altLabel	"trimethyllysine,2-oxoglutarate dioxygenase"
RHEA:14181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trimethyllysine dioxygenase"
RHEA:14181	skos:altLabel	"epsilon-trimethyllysine 2-oxoglutarate dioxygenase"
RHEA:14181	skos:prefLabel	"trimethyllysine dioxygenase"
RHEA:14181	skos:altLabel	"TML dioxygenase"
RHEA:14181	skos:altLabel	"trimethyllysine alpha-ketoglutarate dioxygenase"
RHEA:14181	skos:altLabel	"TML-alpha-ketoglutarate dioxygenase"
RHEA:14181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate
GO:0047492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthan lyase activity
REACT:R-DME-1497853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Drosophila melanogaster)
RHEA:44796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-13 + S-adenosyl-L-methionine = H(+) + menaquinol-13 + S-adenosyl-L-homocysteine
RHEA:55801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-5624951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNPO1 binds KIF17 dimer (Canis familiaris)
REACT:R-XTR-997237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B proteins bind JAK2 (Xenopus tropicalis)
RHEA:25381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpentadecanal + formyl-CoA => 2-hydroxy-3-methylhexadecanoyl-CoA
REACT:R-CFA-5665999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 translocates from cytosol to the nucleus (Canis familiaris)
RHEA:40427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-MMU-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Mus musculus)
REACT:R-HSA-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)
RHEA:53822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxolithocholate + H(+) + NADPH => chenodeoxycholate + NADP(+)
RHEA:30116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + H2O => decanoate + H(+) + holo-[ACP]
RHEA:15038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + S-adenosyl-L-methionine => H(+) + N-methylputrescine + S-adenosyl-L-homocysteine
REACT:R-BTA-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Bos taurus)
REACT:R-SSC-9696179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Sus scrofa)
REACT:R-RNO-182990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty sequesters CBL away from active EGFR (Rattus norvegicus)
RHEA:56124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-lycopene + dimethylallyl diphosphate + H2O = AH2 + diphosphate + nonaflavuxanthin
GO:0035717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine (C-C motif) ligand 7 binding
GO:0035717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCL7 binding
RHEA:30527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = ADP + ATP + 2 H(+)
REACT:R-XTR-444047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR3 binds carboxylates (Xenopus tropicalis)
RHEA:26445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + ethanol <=> a ubiquinol + acetaldehyde
REACT:R-BTA-1602446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Bos taurus)
REACT:R-GGA-216756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)
RHEA:57042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apiofuranose => aldehydo-D-apiose
REACT:R-DRE-8849042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS3 (Danio rerio)
RHEA:62787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 fonsecin B + H(+) + NADPH + O2 <=> bifonsecin B + 2 H2O + NADP(+)
REACT:R-RNO-140825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Rattus norvegicus)
RHEA:57786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,4-dinitrobenzene + NADH + O2
REACT:R-DRE-110376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Danio rerio)
RHEA:69711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O = beta-D-glucose + N-hexadecanoylsphinganine
REACT:R-GGA-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Gallus gallus)
REACT:R-DRE-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Danio rerio)
RHEA:21648	skos:prefLabel	"prephenate dehydratase"
RHEA:21648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O
RHEA:21648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prephenate dehydratase"
RHEA:51594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene
RHEA:25429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-hexosamine => ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate
REACT:R-DDI-9014420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the phagocytic vesicle membrane (Dictyostelium discoideum)
RHEA:68690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate)
RHEA:51058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + androsta-1,4-diene-3,17-dione => A + androst-4-ene-3,17-dione
REACT:R-CFA-6782004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the pre-incision complex in TC-NER (Canis familiaris)
GO:0008138	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dual-specificity protein phosphatase
GO:0008138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine/serine/threonine phosphatase activity
REACT:R-CFA-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Canis familiaris)
GO:0005499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin D binding
GO:0005499	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calciferol binding
GO:0005499	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ergocalciferol binding
GO:0005499	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cholecalciferol binding
REACT:R-SSC-77271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Sus scrofa)
RHEA:27573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glycero-alpha-D-manno-heptose 7-phosphate <=> ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)
REACT:R-HSA-6786166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
REACT:R-MMU-158468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates PARA to PARA-SO4 (Mus musculus)
REACT:R-HSA-4551768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO2,3 (Homo sapiens)
REACT:R-DRE-193727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)
REACT:R-DRE-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Danio rerio)
REACT:R-GGA-75079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC C complex (Gallus gallus)
RHEA:34195	skos:prefLabel	"aureusidin synthase"
RHEA:34195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 = 2 aureusidin 6-O-beta-glucoside + 2 H2O
RHEA:34195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aureusidin synthase"
REACT:R-DRE-3295580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPM4,5 transport extracellular Na+ to cytosol (Danio rerio)
RHEA:10171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:56455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-hapalindole U
RHEA:56238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
REACT:R-RNO-8954398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer hydrolyses cardiolipin to PA and PG (Rattus norvegicus)
REACT:R-CFA-5686074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Canis familiaris)
REACT:R-SSC-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Sus scrofa)
REACT:R-SSC-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Sus scrofa)
RHEA:70857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-serine(out) + Na(+)(in) => L-glutamine(out) + L-serine(in) + Na(+)(out)
REACT:R-CFA-2029452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to phosphorylated ITAMs (Canis familiaris)
RHEA:22389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N(6)-hydroxy-L-lysine => CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine
REACT:R-DRE-6805126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates TP53 (Danio rerio)
RHEA:14008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L,L-cystathionine <=> 2-oxobutanoate + L-cysteine + NH4(+)
GO:0090483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity
GO:0090483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cardiolipin synthase
REACT:R-DME-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Drosophila melanogaster)
RHEA:15302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apiitol + NAD(+) => aldehydo-D-apiose + H(+) + NADH
REACT:R-CEL-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)
RHEA:17415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-HSA-1606345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IRF3 to activated ZBP1:TBK1 (Homo sapiens)
REACT:R-HSA-5638016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2:ARL3:GDP:UNC119B dissociates (Homo sapiens)
REACT:R-RNO-451757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of nephrin and KIRREL2, KIRREL3 (Rattus norvegicus)
RHEA:57508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"staphylopine dehydrogenase"
RHEA:57508	skos:prefLabel	"staphylopine dehydrogenase"
RHEA:57508	skos:altLabel	"staphylopine synthase"
RHEA:57508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + staphylopine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate
REACT:R-RNO-4641205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPO:LGR binds ZNRF3 (Rattus norvegicus)
REACT:R-CFA-5625797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Canis familiaris)
REACT:R-BTA-3965450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits PFN1 (Bos taurus)
RHEA:50555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin C1 <=> prostaglandin B1
GO:0097621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amine:oxygen oxidoreductase (deaminating) activity
GO:0097621	skos:altLabel	"tyramine oxidase"
GO:0097621	skos:altLabel	"amine oxidase"
GO:0097621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monoamine oxidase"
GO:0097621	skos:altLabel	"amine oxidase (flavin-containing)"
GO:0097621	skos:altLabel	"tyraminase"
GO:0097621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoamine oxidase activity
GO:0097621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2
GO:0097621	skos:prefLabel	"monoamine oxidase"
GO:0097621	skos:altLabel	"adrenaline oxidase"
REACT:R-CEL-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Caenorhabditis elegans)
REACT:R-SSC-5696358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREM,CD300 binds lipids (Sus scrofa)
RHEA:19844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9672168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of PDGFR mutants (Homo sapiens)
REACT:R-BTA-4084976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)
RHEA:10104	skos:prefLabel	"gibberellin 3beta-dioxygenase"
RHEA:10104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gibberellin 3beta-dioxygenase"
RHEA:10104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A20 + O2 = CO2 + gibberellin A1 + succinate
RHEA:10104	skos:altLabel	"gibberellin 3beta-hydroxylase"
RHEA:34347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + NAD(+) = (2E)-geranial + H(+) + NADH
RHEA:34347	skos:prefLabel	"geraniol dehydrogenase (NAD(+))"
RHEA:34347	skos:altLabel	"GeDH"
RHEA:34347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geraniol dehydrogenase (NAD(+))"
REACT:R-HSA-9625540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cys-sulfenyl chloride is converted to Cys-sulfenic acid (Homo sapiens)
GO:0050624	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-dihydrovomilenine:NADP+ oxidoreductase activity
GO:0050624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vomilenine reductase activity
GO:0050624	skos:prefLabel	"vomilenine reductase"
GO:0050624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vomilenine reductase"
GO:0050624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine
RHEA:55171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-SSC-216082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaXbeta2 with fibrin (Sus scrofa)
RHEA:57750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH
RHEA:16753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 = 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)
REACT:R-BTA-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Bos taurus)
RHEA:52186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:55788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + H(+) + NADH + O2 = H2O + hydroxyacetone + NAD(+)
GO:0102336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-arachidoyl-CoA synthase activity
GO:0102336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CO2 + CoA
RHEA:66904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cannabinerolate = AH2 + cannabichromenate
RHEA:17419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate => ATP + N-acetyl-D-glucosamine
RHEA:54269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 => (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate
RHEA:54344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:26259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroabietadienal + 2 H2O + NADP(+) => dehydroabietadienol + H(+) + NADPH + O2
REACT:R-CFA-210283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and PLC gamma1 (Canis familiaris)
REACT:R-CFA-9708859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Canis familiaris)
GO:0042409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl coenzyme A methyltransferase activity
GO:0042409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity
GO:0042409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl-CoA O-methyltransferase activity
GO:0042409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl-CoA 3-O-methyltransferase activity
GO:0042409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-caffeoyl-CoA 3-O-methyltransferase activity
RHEA:46051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactosamine 6-phosphate <=> alpha-D-galactosamine 1-phosphate
REACT:R-CEL-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Caenorhabditis elegans)
REACT:R-BTA-3928656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves EPHB2 (Bos taurus)
RHEA:19997	skos:prefLabel	"phosphoenolpyruvate phosphatase"
RHEA:19997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoenolpyruvate phosphatase"
RHEA:19997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphoenolpyruvate = phosphate + pyruvate
REACT:R-DME-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Drosophila melanogaster)
REACT:R-XTR-4551649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO1 (Xenopus tropicalis)
REACT:R-MMU-5638016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2:ARL3:GDP:UNC119B dissociates (Mus musculus)
RHEA:51235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin D2
GO:0032266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3-phosphate binding
GO:0032266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol 3-phosphate binding
GO:0032266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtdIns-3-P binding
GO:0034647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity (H3-trimethyl-K4 specific)
GO:0034647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity (H3-K4-me3 specific)
GO:0034647	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H3K4me3 demethylase activity
GO:0034647	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K4me2 demethylase activity
GO:0034647	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H3-K4me3 demethylase activity
GO:0034647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-tri/di/monomethyl-lysine-4 demethylase activity
GO:0034647	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K4me2 demethylase activity
GO:0034647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K4me/H3K4me2/H3K4me3 demethylase activity
RHEA:29567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)
RHEA:47237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:47991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-galactonate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH
REACT:R-GGA-419153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)
RHEA:43328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-HSA-69685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TP53 (Homo sapiens)
RHEA:40860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + FAD + H(+) => (2E,9Z)-hexadecadienoyl-CoA + FADH2
REACT:R-MMU-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Mus musculus)
RHEA:41690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-BTA-5689973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10,USP24,USP42 deubiquitinate TP53 (Bos taurus)
RHEA:28463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal(in) => pyridoxal(out)
REACT:R-HSA-1454843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by MMP3, MMP7 and plasmin. (Homo sapiens)
REACT:R-GGA-1222685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathelicidin LL-37 binds to bacterial cell wall (Gallus gallus)
RHEA:36722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosenoylsphinganine
REACT:R-SSC-4084999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU1 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)
RHEA:66901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-tryptophan + malonyl-CoA => CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O
GO:0050071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysyltransferase activity
GO:0050071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity
GO:0050071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity
RHEA:47880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioctanoylglycerol + H2O = H(+) + octanoate + octanoylglycerol
REACT:R-CFA-5690702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN phosphorylates CD22 (Canis familiaris)
REACT:R-HSA-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
REACT:R-DRE-5654514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds FGFR1c (Danio rerio)
RHEA:41420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 = CO2 + grixazone B + 4 H2O
REACT:R-CEL-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)
REACT:R-BTA-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Bos taurus)
REACT:R-RNO-2213205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type XII and XIV collagens associate with type I and type II fibrils. (Rattus norvegicus)
REACT:R-RNO-9007901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RL2 (Rattus norvegicus)
REACT:R-SSC-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Sus scrofa)
GO:0047088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)
GO:0047088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine 10-monooxygenase activity
GO:0047088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine 10-hydroxylase activity
RHEA:46761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitrotoluene + NADH + O2 => 4-methyl-5-nitrocatechol + NAD(+) + nitrite
REACT:R-RNO-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Rattus norvegicus)
GO:0033942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity
GO:0033942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malto-oligosyltrehalose trehalohydrolase activity
GO:0033942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltooligosyl trehalose trehalohydrolase activity
GO:0033942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-alpha-D-{(1,4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity
GO:0033942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity
RHEA:10457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-maltose => 1-O-acetylmaltose + CoA
RHEA:34165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+) => hydroquinone + O2
RHEA:36452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-glutamate(out) + H2O => ADP + glycyl-L-glutamate(in) + H(+) + phosphate
RHEA:26386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal
REACT:R-HSA-204465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Basigin interacts with CD43 (Homo sapiens)
RHEA:41498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine
GO:0050379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucuronate 5'-epimerase activity
GO:0050379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronic acid epimerase activity
GO:0050379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucuronate 5'-epimerase activity
GO:0050379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucuronate 5' epimerase activity
GO:0050379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C-5-uronosyl epimerase activity
GO:0050379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronic acid 5'-epimerase activity
GO:0050379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucuronate 5'-epimerase activity
REACT:R-CEL-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Caenorhabditis elegans)
GO:0102914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-3-aminomethylindole N-methyltransferase activity
REACT:R-SSC-443910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 dissociates from integrin alphaIIb beta3 (Sus scrofa)
RHEA:35602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADPH
REACT:R-CFA-2152276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of transmembrane collagens (Canis familiaris)
RHEA:32589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2
REACT:R-HSA-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Homo sapiens)
RHEA:22071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> (2S)-2-acetolactate + H(+) + NADPH
REACT:R-XTR-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Xenopus tropicalis)
RHEA:12157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH
REACT:R-DRE-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Danio rerio)
RHEA:48539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O <=> 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)
REACT:R-DME-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)
RHEA:58579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate + NADP(+) <=> H(+) + NADPH + precondylocarpine acetate
REACT:R-MMU-159728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-prothrombin to prothrombin (Mus musculus)
REACT:R-HSA-8956652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH gene expression is stimulated by RUNX1 and YAP1 (Homo sapiens)
REACT:R-SPO-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Schizosaccharomyces pombe)
RHEA:21134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + urate => H2O + O2 + xanthine
RHEA:14847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-dihydrodipicolinate + H(+) + 2 H2O => L-aspartate 4-semialdehyde + pyruvate
REACT:R-MMU-4719423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO3 (Mus musculus)
REACT:R-CFA-5665998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 binds SRF (Canis familiaris)
REACT:R-MMU-5674132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Mus musculus)
GO:0009014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinyl-diaminopimelate desuccinylase"
GO:0009014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-diaminopimelate desuccinylase activity
GO:0009014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity
GO:0009014	skos:prefLabel	"succinyl-diaminopimelate desuccinylase"
GO:0009014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity
GO:0009014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate
REACT:R-SSC-2161660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGE2 by PTGES (Sus scrofa)
REACT:R-SCE-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Saccharomyces cerevisiae)
RHEA:46647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + H(+) + NADPH <=> 5beta-dihydrocortisol + NADP(+)
REACT:R-MMU-549241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Mus musculus)
RHEA:72850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate(in) + ADP(out) <=> adenosine 3',5'-bisphosphate(out) + ADP(in)
RHEA:10768	skos:altLabel	"leucocyanidin oxygenase"
RHEA:10768	skos:prefLabel	"anthocyanidin synthase"
RHEA:10768	skos:altLabel	"leucoanthocyanidin dioxygenase"
RHEA:10768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate
RHEA:10768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanidin synthase"
REACT:R-DME-5660660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p300 acetylates RELA subunit (Drosophila melanogaster)
REACT:R-PFA-5618331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC6 deacetylates microtubules (Plasmodium falciparum)
RHEA:12160	skos:prefLabel	"2-deoxy-D-gluconate 3-dehydrogenase"
RHEA:12160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-deoxy-D-gluconate 3-dehydrogenase"
RHEA:12160	skos:altLabel	"2-deoxygluconate dehydrogenase"
RHEA:12160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH
RHEA:38119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-DRE-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Danio rerio)
RHEA:70803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate
REACT:R-HSA-8951850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Homo sapiens)
RHEA:62014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine
RHEA:47873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + H2O => ganglioside GA1 + N-acetylneuraminate
REACT:R-XTR-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Xenopus tropicalis)
REACT:R-HSA-169468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2-7 mediated fork unwinding (Homo sapiens)
REACT:R-RNO-166245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Rattus norvegicus)
REACT:R-BTA-1606288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Bos taurus)
RHEA:23241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate
REACT:R-CFA-74740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SHC1 to insulin receptor (Canis familiaris)
REACT:R-BTA-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Bos taurus)
REACT:R-SPO-9626880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)
REACT:R-MMU-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Mus musculus)
REACT:R-GGA-353300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGMT mediated DNA Damage Reversal (Gallus gallus)
REACT:R-GGA-8851900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1-2 bound to MET recruits GRB2:SOS1 (Gallus gallus)
REACT:R-DRE-380303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Phospho-Nlp from the centrosome (Danio rerio)
EC:3.2.1.1	skos:prefLabel	"alpha-amylase"
EC:3.2.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-amylase"
EC:3.2.1.1	skos:altLabel	"glycogenase"
RHEA:10836	skos:prefLabel	"questin monooxygenase"
RHEA:10836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + questin = demethylsulochrin + NADP(+)
RHEA:10836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"questin monooxygenase"
RHEA:10836	skos:altLabel	"questin oxygenase"
RHEA:24950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA + malonate => 3-hydroxy-3-methylglutarate + malonyl-CoA
RHEA:40767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside R1 + H2O = (20S)-ginsenoside Rg1 + D-xylose
REACT:R-MMU-5654625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds SHC1 (Mus musculus)
REACT:R-BTA-176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST trimers transfer GS from GSH to luminal substrates (Bos taurus)
REACT:R-PFA-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Plasmodium falciparum)
RHEA:11217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + ATP => a 2'-deoxyribonucleoside 5'-diphosphate + ADP
REACT:R-CEL-201648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, Endofin, recruits R-Smad1/5/8 (Caenorhabditis elegans)
REACT:R-CFA-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Canis familiaris)
REACT:R-SSC-6789072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP1 binds bacterial peptidoglycan (Sus scrofa)
REACT:R-HSA-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Homo sapiens)
REACT:R-HSA-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Homo sapiens)
REACT:R-GGA-3229089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Gallus gallus)
REACT:R-MMU-1638053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from keratan sulfate (Mus musculus)
RHEA:66009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O
RHEA:53258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lathosterol + O2 + reduced [NADPH--hemoprotein reductase]
GO:1902516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate binding
GO:0102463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity
RHEA:42662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => NAD(+) + UDP-N-acetyl-alpha-D-glucosamine
RHEA:69122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + glycine => glyoxylate + L-phenylalanine
GO:0016210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naringenin-chalcone synthase activity
GO:0016210	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
GO:0016210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA
GO:0016210	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DOCS
REACT:R-BTA-2294580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 hyperphosphorylates Condensin II complex (Bos taurus)
REACT:R-BTA-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Bos taurus)
GO:0009037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	site-specific tyrosine recombinase activity
GO:0009037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine-based site-specific recombinase activity
GO:0009037	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tyrosine recombinase
RHEA:49401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + validoxylamine A 7'-phosphate => phosphate + validoxylamine A
RHEA:67065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + asnovolin K => A + asnovolin A
RHEA:54832	skos:altLabel	"CYP94B1"
RHEA:54832	skos:altLabel	"CYP94B3"
RHEA:54832	skos:prefLabel	"jasmonoyl-L-amino acid 12-hydroxylase"
RHEA:54832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"jasmonoyl-L-amino acid 12-hydroxylase"
RHEA:54832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:68224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + O2 + prekainate = CO2 + H2O + kainate lactone + succinate
RHEA:20991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 2 H2O <=> AMP + 2 H(+) + 2 phosphate
RHEA:13809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspulvinone dimethylallyltransferase"
RHEA:13809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate
RHEA:13809	skos:prefLabel	"aspulvinone dimethylallyltransferase"
RHEA:24177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-140216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PMAIP1 (NOXA) to mitochondria (Homo sapiens)
REACT:R-MMU-8848247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD4,5 bind MCFA-CoA and LCFA-CoA (Mus musculus)
REACT:R-MMU-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Mus musculus)
RHEA:19753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + diphthine-[translation elongation factor 2] + NH4(+) = AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)
RHEA:19753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diphthine--ammonia ligase"
RHEA:19753	skos:altLabel	"diphthamide synthetase"
RHEA:19753	skos:altLabel	"diphthamide synthase"
RHEA:19753	skos:prefLabel	"diphthine--ammonia ligase"
REACT:R-CFA-1676174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Canis familiaris)
REACT:R-XTR-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Xenopus tropicalis)
REACT:R-HSA-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Homo sapiens)
REACT:R-DRE-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Danio rerio)
RHEA:36331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate
REACT:R-XTR-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Xenopus tropicalis)
REACT:R-RNO-351987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A6-mediated uptake of taurine and beta-alanine (Rattus norvegicus)
REACT:R-BTA-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Bos taurus)
GO:0004536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonuclease activity
GO:0004536	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	caspase-activated deoxyribonuclease activity
RHEA:37886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + oxalate <=> acetate + oxalyl-CoA
REACT:R-CEL-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Caenorhabditis elegans)
REACT:R-HSA-5610723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind SUFU (Homo sapiens)
REACT:R-CFA-418918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The UDP/CysLT (P2Y17) receptor can bind UTP (Canis familiaris)
REACT:R-DRE-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Danio rerio)
REACT:R-DRE-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Danio rerio)
RHEA:37426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin N + O2 <=> aclacinomycin A + H2O2
REACT:R-HSA-1889981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
GO:0033893	skos:prefLabel	"ribonuclease IV"
GO:0033893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoribonuclease IV activity
GO:0033893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease IV"
GO:0033893	skos:altLabel	"endoribonuclease IV"
GO:0033893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease IV activity
GO:0033893	skos:altLabel	"poly(A)-specific ribonuclease"
RHEA:23334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + GDP => (2R)-3-phosphoglycerate + GTP
REACT:R-CEL-5634802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Caenorhabditis elegans)
REACT:R-MMU-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Mus musculus)
REACT:R-HSA-201472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Homo sapiens)
REACT:R-XTR-2090037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(6) (Xenopus tropicalis)
REACT:R-RNO-4341025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR3C1 (GR) with SUMO1 (Rattus norvegicus)
RHEA:32446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:53633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (3S)-(+)-asterisca-2(9),6-diene + diphosphate
REACT:R-CFA-2426450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins:Nidogens binds collagen type IV networks (Canis familiaris)
RHEA:52864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-XTR-9708104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE5A dimer binds PDE5A inhibitors (Xenopus tropicalis)
REACT:R-MMU-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Mus musculus)
RHEA:44047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
RHEA:23437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O => 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate
REACT:R-MMU-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Mus musculus)
REACT:R-RNO-77586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Rattus norvegicus)
RHEA:49472	skos:prefLabel	"hydroxyproline O-arabinosyltransferase"
RHEA:49472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyproline O-arabinosyltransferase"
RHEA:49472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose = H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP
RHEA:49472	skos:altLabel	"HPAT"
RHEA:67802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2
RHEA:27836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + fumarate => a menaquinone + succinate
RHEA:55541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] => 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate
GO:0086085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication
GO:0086085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesive protein binding involved in SA cardiomyocyte-atrial cardiomyocyte communication
REACT:R-HSA-114264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAX to the mitochondria (Homo sapiens)
RHEA:27758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)
RHEA:27758	skos:altLabel	"GCV"
RHEA:27758	skos:prefLabel	"glycine cleavage system"
RHEA:27758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine cleavage system"
RHEA:38975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-RNO-3465459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Rattus norvegicus)
RHEA:59705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellohexaono-1,5-lactone + H2O => D-cellohexaonate + H(+)
REACT:R-CEL-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Caenorhabditis elegans)
RHEA:40212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanedioyl-CoA + NAD(+) => 3-oxotetradecanedioyl-CoA + H(+) + NADH
RHEA:66512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:13557	skos:altLabel	"glutathione synthetase"
RHEA:13557	skos:prefLabel	"glutathione synthase"
RHEA:13557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione synthase"
RHEA:13557	skos:altLabel	"GSH synthetase"
RHEA:13557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate
REACT:R-DRE-1370505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR is phosphorylated at Ser-349 (Danio rerio)
REACT:R-SSC-419389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA-binding receptors bind LPA (Sus scrofa)
RHEA:48636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O
RHEA:31476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol B + UDP-alpha-D-glucuronate => H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP
RHEA:69736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylsuccinate + succinyl-CoA => 2-phenylsuccinyl-CoA + succinate
RHEA:16710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan
REACT:R-DRE-9733964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Danio rerio)
REACT:R-BTA-9024766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Bos taurus)
REACT:R-RNO-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Rattus norvegicus)
REACT:R-XTR-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Xenopus tropicalis)
REACT:R-CFA-6814675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Canis familiaris)
REACT:R-DME-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Drosophila melanogaster)
RHEA:37025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2
REACT:R-DME-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Drosophila melanogaster)
REACT:R-XTR-168400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iE-DAP elicits a NOD1 response (Xenopus tropicalis)
RHEA:41221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O
REACT:R-DME-8876616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND6A,B exchange GTP for GDP on RAB14 (Drosophila melanogaster)
RHEA:65367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
REACT:R-HSA-9658813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1 S326C is oxidized (Homo sapiens)
REACT:R-SSC-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)
REACT:R-RNO-5665751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP:FMNL2 binds Profilin:G-actin (Rattus norvegicus)
RHEA:69861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 12S rRNA + S-adenosyl-L-methionine
REACT:R-HSA-193668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR and RHOA-GDI interact (Homo sapiens)
RHEA:41750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol
RHEA:11059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 2 H(+) + NADPH + O2 <=> 4-aminophenol + CO2 + H2O + NADP(+)
REACT:R-DRE-8854628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLIP dimer ubiquitinates VLDLR on Lys-839 (Danio rerio)
RHEA:42208	skos:altLabel	"omega-(methylthio)alkylglucosinolate S-oxygenase"
RHEA:42208	skos:prefLabel	"aliphatic glucosinolate S-oxygenase"
RHEA:42208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aliphatic glucosinolate S-oxygenase"
RHEA:42208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 = a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)
REACT:R-GGA-4093331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras:GTP binds p120-RasGAP (Gallus gallus)
RHEA:35656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP => 3',3'-c-di-AMP + 2 diphosphate
RHEA:35369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoheptadecanoyl-coA + NADP(+) => (2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH
REACT:R-CEL-2537665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin-1 and -2 bind fibronectin (Caenorhabditis elegans)
RHEA:70548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP
RHEA:44956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA + H(+) + NADPH = hexanoyl-CoA + NADP(+)
RHEA:24163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + O2 <=> D-galacto-hexodialdose + H2O2
RHEA:59991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1-carbonyl-CoA + NADP(+) <=> cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH
REACT:R-HSA-212713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLC-gamma1 dissociates from EGFR (Homo sapiens)
RHEA:21506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde => acetoin + aldehydo-D-ribose 5-phosphate
RHEA:58239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]
REACT:R-CFA-9007901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RL2 (Canis familiaris)
RHEA:39391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)
REACT:R-HSA-75825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of Cyclin D1 (Homo sapiens)
REACT:R-SSC-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Sus scrofa)
RHEA:23161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnopyranose => L-rhamnulose
REACT:R-BTA-5218820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src kinases phosphorylate VAV (Bos taurus)
RHEA:57813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-2-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite
REACT:R-DRE-176700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Danio rerio)
RHEA:72932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] => atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0047565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropionate dehydrogenase (NAD+) activity
GO:0047565	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxypropanoate:NAD+ oxidoreductase activity
REACT:R-SSC-2213239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MHC II alpha beta heterodimer (Sus scrofa)
RHEA:23162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnulose => L-rhamnopyranose
RHEA:51239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate
REACT:R-CFA-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Canis familiaris)
RHEA:16369	skos:prefLabel	"D-lactate dehydrogenase"
RHEA:16369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + NAD(+) = H(+) + NADH + pyruvate
RHEA:16369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-lactate dehydrogenase"
RHEA:16369	skos:altLabel	"D-lactic dehydrogenase"
RHEA:16369	skos:altLabel	"D-lactic acid dehydrogenase"
REACT:R-HSA-9619783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK1 phosphorylates ARHGEF7-1 (Homo sapiens)
REACT:R-CEL-8964614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Caenorhabditis elegans)
REACT:R-SCE-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Saccharomyces cerevisiae)
GO:0034634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione transmembrane transporter activity
REACT:R-SSC-211186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DFF45 (224) by caspase-3 (Sus scrofa)
RHEA:34233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitro-6-oxohepta-2,4-dienedioate + H(+) => 5-nitrosalicylate + O2
REACT:R-CEL-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Caenorhabditis elegans)
GO:0016639	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0016639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
GO:0016639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
REACT:R-CFA-5683964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates EYA1-4 (Canis familiaris)
RHEA:14826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH
REACT:R-RNO-9034855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK3 (Rattus norvegicus)
RHEA:53243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:64694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanal + H(+) + NADH => isobutanol + NAD(+)
REACT:R-DDI-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Dictyostelium discoideum)
REACT:R-GGA-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Gallus gallus)
REACT:R-MMU-9733292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind pramlintide (Mus musculus)
RHEA:40301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:62578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-cystine(in) + phosphate => ATP + H2O + L-cystine(out)
RHEA:52023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> A + H2O + resolvin E2
RHEA:68862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-25-dihydroxycholesterol + NADP(+) => 7-oxo-25-hydroxycholesterol + H(+) + NADPH
RHEA:63792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate
REACT:R-CFA-5624130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylated NPHP3 translocates into the ciliary membrane (Canis familiaris)
REACT:R-XTR-5138433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Xenopus tropicalis)
REACT:R-MMU-5579023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA2(869-1464) binds KAT6A(1-1118) (Mus musculus)
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	yeast alcohol dehydrogenase
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADH
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent alcohol dehydrogenase
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-aldehyde dehydrogenase
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldo-keto reductase (NAD) activity
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ethanol dehydrogenase
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-alcohol dehydrogenase
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alcohol dehydrogenase activity
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alcohol:NAD+ oxidoreductase
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol dehydrogenase (NAD+) activity
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aliphatic alcohol dehydrogenase
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aldehyde dehydrogenase (NAD) activity
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-specific aromatic alcohol dehydrogenase
GO:0004022	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	primary alcohol dehydrogenase
REACT:R-CFA-5693925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers L-fucose to Gal1,3GlcNAc (Canis familiaris)
RHEA:27706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-alanine--D-serine ligase"
RHEA:27706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanine + D-serine = ADP + D-alanyl-D-serine + H(+) + phosphate
RHEA:27706	skos:prefLabel	"D-alanine--D-serine ligase"
REACT:R-HSA-9796691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPATA2 links CYLD to LUBAC (Homo sapiens)
REACT:R-DDI-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Dictyostelium discoideum)
REACT:R-BTA-168140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Bos taurus)
RHEA:37572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-BTA-5654697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
RHEA:41526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol => 5 H(+) + 5 malonyl-CoA
REACT:R-SSC-204863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang2 (Sus scrofa)
REACT:R-XTR-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Xenopus tropicalis)
RHEA:58356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + L-arginyl-[protein] + succinate
REACT:R-BTA-8857925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Bos taurus)
REACT:R-SSC-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Sus scrofa)
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetate beta-glucosyltransferase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IAA-Glu synthetase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-indoleacetate glucosyltransferase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IAGlu synthase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:indol-3-acetic acid glucosyltransferase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:indol-3-ylacetate glucosyl-transferase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IAA-glucose synthase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	UDP-glucose:auxin glucosyltransferase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG-indol-3-ylacetyl glucosyl transferase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:indol-3-ylacetate glucosyltransferase activity
GO:0047215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indol-3-ylacetylglucose synthase activity
REACT:R-BTA-416320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR1-containing  AMPA receptors (Bos taurus)
RHEA:23389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hygromycin B => 7''-O-phosphohygromycin B + ADP + H(+)
REACT:R-HSA-8863014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p25-bound CDK5 phosphorylates CDC25A (Homo sapiens)
REACT:R-DRE-74993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Danio rerio)
GO:0052588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetyl reductase ((S)-acetoin forming) activity
GO:0052588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-acetoin dehydrogenase activity
REACT:R-GGA-417898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y4 receptor can bind to UTP (Gallus gallus)
REACT:R-SSC-9702354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCA antibodies (Sus scrofa)
RHEA:17262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aryl sulfate + H2O => a phenol + H(+) + sulfate
REACT:R-BTA-5218827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)
RHEA:21801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin + L-ascorbate => all-trans-zeaxanthin + H2O + L-dehydroascorbate
REACT:R-CFA-8950741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B:IL23A translocates from ER lumen to extracellular space (Canis familiaris)
GO:0033729	skos:altLabel	"ANR"
GO:0033729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ANR
GO:0033729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavan-3-ol:NAD(P)+ oxidoreductase activity
GO:0033729	skos:prefLabel	"anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]"
GO:0033729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MtANR
GO:0033729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanidin reductase activity
GO:0033729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AtANR
GO:0033729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]"
GO:0033729	skos:altLabel	"anthocyanidin reductase"
REACT:R-DDI-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Dictyostelium discoideum)
RHEA:24749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine <=> 2-aminobut-2-enoate + methanethiol
GO:0047592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-pyridoxate dioxygenase activity
GO:0047592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-pyridoxate oxidase activity
RHEA:54546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine
RHEA:66117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-glutamine => (2S)-2-aminobutanoate + 2-oxoglutaramate
RHEA:56672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-4-coumaroyl-CoA + NADP(+) = (E)-4-coumaroyl-CoA + H(+) + NADPH
RHEA:29457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(out) => D-serine(in)
RHEA:58770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH
REACT:R-DRE-205112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Danio rerio)
RHEA:39669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ketone + reduced coenzyme F420-(gamma-L-Glu)(n) => a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-HSA-1222341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 gets scavenged by unsaturated lipid (Homo sapiens)
REACT:R-SSC-211874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2S1 4-hydroxylates atRA (Sus scrofa)
RHEA:22896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)
RHEA:22896	skos:altLabel	"yeast fatty acid synthase"
RHEA:22896	skos:altLabel	"fatty-acyl-CoA synthase"
RHEA:22896	skos:prefLabel	"fatty-acyl-CoA synthase system"
RHEA:22896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty-acyl-CoA synthase system"
REACT:R-CEL-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)
REACT:R-GGA-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Gallus gallus)
GO:0102187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol dehydrogenase/C4-decarboxylase activity
GO:0090486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small RNA 2'-O-methyltransferase
GO:0090486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small RNA 2'-O-methyltransferase activity
RHEA:46362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-DRE-264758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Danio rerio)
REACT:R-CFA-71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Canis familiaris)
RHEA:18649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O
RHEA:66792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-D-dopa + O2 = (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2
RHEA:34392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose => [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP
REACT:R-RNO-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Rattus norvegicus)
RHEA:41615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> D-ribose 2,5-bisphosphate + H(+)
RHEA:53123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH
REACT:R-CEL-379048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Caenorhabditis elegans)
REACT:R-HSA-4085296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NCOA1 with SUMO1 (Homo sapiens)
GO:0052843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity
GO:0052843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
GO:0052843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1-pyrophosphate 2,3,4,5,6-pentakisphosphate 1-pyrophosphatase activity
RHEA:25982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:42261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptanoyl-CoA + malonyl-[ACP] => 3-oxononanoyl-[ACP] + CO2 + CoA
RHEA:69661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + kaempferol => H2O + kaempferol 3-O-beta-D-glucoside
REACT:R-HSA-1482887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Homo sapiens)
REACT:R-BTA-2213208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type X collagen associates with collagen type II fibrils (Bos taurus)
RHEA:24119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> (S)-linalool + diphosphate
RHEA:13188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 4 porphobilinogen <=> hydroxymethylbilane + 4 NH4(+)
GO:0047857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrouracil oxidase activity
GO:0047857	skos:prefLabel	"dihydrouracil oxidase"
GO:0047857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + O2 = H2O2 + uracil
GO:0047857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrouracil oxidase"
GO:0047857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6-dihydrouracil:oxygen oxidoreductase activity
RHEA:40175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octanoyl-CoA = (2E)-octenoyl-CoA + H2O2
GO:0050373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-xylose 4-epimerase activity
GO:0050373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine 5'-diphosphate-D-xylose 4-epimerase activity
GO:0050373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-L-arabinose 4-epimerase activity
GO:0050373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-arabinose 4-epimerase activity
GO:0050373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDParabinose 4-epimerase activity
GO:0050373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP arabinose epimerase activity
GO:0050373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-D-xylose-4-epimerase activity
GO:0050373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoarabinose epimerase activity
REACT:R-SSC-5218906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 phosphorylates MLKL (Sus scrofa)
RHEA:40057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O
REACT:R-DME-5687484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Drosophila melanogaster)
REACT:R-CFA-2509793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)
REACT:R-HSA-4086200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin matrix protein 1 binds integrin alphaVbeta3 (Homo sapiens)
RHEA:48938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein] => 2-oxoglutarate + L-prolyl-[Skp1 protein] + O2
REACT:R-HSA-1605736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Homo sapiens)
REACT:R-DME-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Drosophila melanogaster)
REACT:R-HSA-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)
REACT:R-GGA-372564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)
GO:0000774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenyl-nucleotide exchange factor activity
GO:0000774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
REACT:R-PFA-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Plasmodium falciparum)
REACT:R-DME-379426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Drosophila melanogaster)
RHEA:69188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate
REACT:R-DRE-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Danio rerio)
RHEA:22745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-975097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
RHEA:21085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin 4'-sulfate => dermatan 4'-sulfate
RHEA:25802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acetamidopropanal + H2O2 + spermidine => H2O + N(1)-acetylspermine + O2
REACT:R-HSA-9686930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is cleaved by CASP8 (Homo sapiens)
REACT:R-GGA-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Gallus gallus)
REACT:R-HSA-164845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Suicidal integration leading to inverted circle formation (Homo sapiens)
RHEA:28618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutyronitrile + H(+) + NADPH + O2 = 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)
REACT:R-XTR-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Xenopus tropicalis)
REACT:R-XTR-177944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)
GO:0050344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-cinnamic acid 2-hydroxylase activity
GO:0050344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamic acid 2-hydroxylase activity
GO:0050344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-cinnamate 2-monooxygenase activity
GO:0050344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamic 2-hydroxylase activity
GO:0050344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)
GO:0050344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamate 2-monooxygenase activity
GO:0050344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamate 2-hydroxylase activity
GO:0050035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-sorbose oxidase activity
GO:0050035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-sorbose:oxygen 5-oxidoreductase activity
REACT:R-HSA-9611030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1 (GRIN1) binds to ACTN2 at postsynaptic density (Homo sapiens)
REACT:R-DME-5668947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates myosin phosphatase (Drosophila melanogaster)
RHEA:33921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24,25-dihydrolanosterol + NADP(+) => H(+) + lanosterol + NADPH
REACT:R-XTR-391940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 and EP4 receptors can bind PGE2 (Xenopus tropicalis)
RHEA:47698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O
REACT:R-DME-4341072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RARA with SUMO2 (Drosophila melanogaster)
REACT:R-HSA-5218815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds NCK (Homo sapiens)
REACT:R-DRE-68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated geminin is degraded by the proteasome (Danio rerio)
RHEA:40306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dodecanedioyl-CoA <=> (2E)-dodecenedioyl-CoA + AH2
RHEA:25021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + riboflavin = CDP + FMN + H(+)
RHEA:25021	skos:prefLabel	"CTP-dependent riboflavin kinase"
RHEA:25021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CTP-dependent riboflavin kinase"
RHEA:12031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-5-carboxymethylhydantoin <=> H(+) + N-carbamoyl-L-aspartate
REACT:R-CEL-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Caenorhabditis elegans)
REACT:R-XTR-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)
RHEA:35335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isopentadecanoyl-CoA + malonyl-CoA = 3-oxoisoheptadecanoyl-CoA + CO2 + CoA
REACT:R-HSA-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Homo sapiens)
REACT:R-CFA-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Canis familiaris)
REACT:R-RNO-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Rattus norvegicus)
REACT:R-XTR-141139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of TRAIL:TRAIL receptor complex (Xenopus tropicalis)
RHEA:53704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O = H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine
REACT:R-BTA-9700175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates SHC1 (Bos taurus)
GO:0140790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serine/threonine phosphatase activity
RHEA:15336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + NADP(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADPH
RHEA:24797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O = (S)-2-amino-6-oxoheptanedioate
REACT:R-DME-350405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOGEF2 binds to RHO1:GDP complex at the plasma membrane (Drosophila melanogaster)
REACT:R-GGA-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Gallus gallus)
REACT:R-XTR-190520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Golgi  transport vesicles with microtubules (Xenopus tropicalis)
GO:0015135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronate transmembrane transporter activity
REACT:R-HSA-1791184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ATP6VOD1 (Homo sapiens)
REACT:R-DRE-69144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 (Danio rerio)
GO:0140788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate uniporter activity
GO:0140788	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamate uniporter activity
EC:5.6.1.9	skos:prefLabel	"(R)-2-hydroxyacyl-CoA dehydratase activating ATPase"
EC:5.6.1.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-2-hydroxyacyl-CoA dehydratase activating ATPase"
EC:5.6.1.9	skos:altLabel	"archerase"
EC:5.6.1.9	skos:altLabel	"(R)-2-hydroxyacyl-CoA dehydratase activase"
REACT:R-DME-77591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Drosophila melanogaster)
RHEA:43959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate
RHEA:71361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-sulfate(in) + 2 Na(+)(in) => 17beta-estradiol 17-sulfate(out) + 2 Na(+)(out)
REACT:R-XTR-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Xenopus tropicalis)
REACT:R-HSA-3222259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF20 binds TP53 dimethylated on K370 and K382 (Homo sapiens)
REACT:R-BTA-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)
REACT:R-XTR-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Xenopus tropicalis)
REACT:R-HSA-9762343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDL:ALB dissociates (Homo sapiens)
RHEA:64606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + uridylyl-L-seryl-[protein] => L-seryl-[protein] + UTP
REACT:R-MMU-2161794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is converted to HXA3/B3 by ALOX12 (Mus musculus)
GO:2001085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinogalactan binding
RHEA:21666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + H(+) + phosphate => 4-nitrophenyl phosphate + H2O
REACT:R-MMU-391168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP gamma binds CD47 (Mus musculus)
REACT:R-CFA-9617370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-antagonists bind ADRA1A,B,D (Canis familiaris)
RHEA:43568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADH
REACT:R-DME-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Drosophila melanogaster)
RHEA:72480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + trans-aconitate(in) => citrate(in) + trans-aconitate(out)
RHEA:11969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + kynurenate + O2 => 7,8-dihydro-7,8-dihydroxykynurenate + A
REACT:R-BTA-1678843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein translation regulator 4EHP (Bos taurus)
RHEA:61760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP
RHEA:66673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) => 5,7-dihydroxy-4-methylphthalide + H2O
GO:0018030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-lysine N6-myristoyltransferase activity
REACT:R-SPO-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Schizosaccharomyces pombe)
REACT:R-RNO-1855202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Rattus norvegicus)
REACT:R-BTA-9627078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP9 (Bos taurus)
REACT:R-MMU-2161792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Mus musculus)
REACT:R-DRE-5625959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Danio rerio)
REACT:R-DDI-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)
RHEA:13342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine
RHEA:57927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mutildienyl diphosphate <=> diphosphate + premutilin
REACT:R-HSA-4411357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene (Homo sapiens)
RHEA:23611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-isopropylammelide <=> cyanurate + isopropylamine
RHEA:36006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxy-2-oxohexanoate <=> propanal + pyruvate
GO:0090729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toxin receptor binding
GO:0090729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toxin activity
REACT:R-GGA-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Gallus gallus)
RHEA:72559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + pentanoate(in) = estrone 3-sulfate(in) + pentanoate(out)
RHEA:18358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tropine => H(+) + NADPH + tropinone
REACT:R-CFA-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Canis familiaris)
RHEA:17746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP
RHEA:62914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+) => H(+) + NADH + O2 + toralactone
REACT:R-BTA-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Bos taurus)
RHEA:72016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine => 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A
REACT:R-HSA-4655440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
RHEA:50500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]
REACT:R-DRE-2130725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of MHC II:Ii clathrin coated vesicle (Danio rerio)
GO:0015444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	magnesium importing ATPase activity
GO:0015444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mg2+-importing ATPase activity
GO:0015444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate
GO:0015444	skos:altLabel	"Mg(2+)-importing ATPase"
GO:0015444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP phosphohydrolase (Mg2+-importing)
GO:0015444	skos:prefLabel	"P-type Mg(2+) transporter"
GO:0015444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	magnesium-translocating P-type ATPase activity
GO:0015444	skos:altLabel	"magnesium-translocating P-type ATPase"
GO:0015444	skos:altLabel	"Mg(2+)-transporting P-type ATPase"
GO:0015444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mg(2+)-importing ATPase activity
GO:0015444	skos:altLabel	"Mg(2+)-transporting ATPase"
GO:0015444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type magnesium transporter activity
GO:0015444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	magnesium transmembrane transporter activity, phosphorylative mechanism
GO:0015444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type Mg(2+) transporter"
REACT:R-HSA-2029457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIIA with IgG-coated Ag (Homo sapiens)
RHEA:51233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin D2
RHEA:33901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose
REACT:R-XTR-391937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP/CysLT receptor can bind cysteinyl leukotrienes (Xenopus tropicalis)
REACT:R-MMU-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Mus musculus)
REACT:R-XTR-5687653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Xenopus tropicalis)
RHEA:45270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4',4'-dihydroxyechinenone + A + H2O => 4'-hydroxyechinenone + AH2 + O2
RHEA:65219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-CoA + H2O <=> 3-oxododecanoate + CoA + H(+)
REACT:R-RNO-196086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Rattus norvegicus)
RHEA:10781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH
REACT:R-XTR-6813659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE, CTSG or PRTN3 binds bacteria (Xenopus tropicalis)
GO:0102074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPC6-trans-2-enoyl-CoA hydratase activity
RHEA:24098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isoscoparin + S-adenosyl-L-homocysteine => isoorientin + S-adenosyl-L-methionine
REACT:R-SSC-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Sus scrofa)
REACT:R-HSA-9610802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN3A (GRIN3A), GluN3B (GRIN3B) NMDA receptors traffic to the plasma membrane (Homo sapiens)
REACT:R-XTR-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Xenopus tropicalis)
GO:0008732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine acetaldehyde-lyase activity
GO:0008732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LtaA
GO:0008732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine aldolase activity
REACT:R-SCE-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Saccharomyces cerevisiae)
REACT:R-RNO-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Rattus norvegicus)
RHEA:14701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CoA + NAD(+) = CoA-disulfide + H(+) + NADH
REACT:R-MMU-418442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Mus musculus)
REACT:R-HSA-5218851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Homo sapiens)
REACT:R-SSC-9014641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Sus scrofa)
REACT:R-CFA-9603419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds SRC (Canis familiaris)
REACT:R-DRE-5634221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 binds TRAF2 within TNFR1 signaling complex (Danio rerio)
REACT:R-SPO-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Schizosaccharomyces pombe)
RHEA:30752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexadecanoate => AMP + diphosphate + hexadecanoyl-CoA
REACT:R-DRE-201472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Danio rerio)
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAHP synthase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxyphosphoheptonate aldolase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DS-Co activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-keto-3-deoxyheptonic aldolase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DS-Mn activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAH7-P synthase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-keto-3-deoxyheptanoate aldolase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KDPH synthetase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-oxo-3-deoxyheptonate aldolase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHAP synthase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-dehydro-3-deoxyheptonate aldolase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-erythrose-4-phosphate-lyase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KDPH synthase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-7-phosphoheptulonate synthase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-keto-3-deoxyheptonate aldolase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity
GO:0003849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-phosphoheptonate aldolase activity
RHEA:45452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetradecanoylethanolamine = ethanolamine + tetradecanoate
RHEA:58098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + tetracosanoate => 1-tetracosanoylglycerol + H2O
GO:0016724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on metal ions, oxygen as acceptor
GO:0016724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
GO:0016724	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
GO:0016724	skos:prefLabel	"With oxygen as acceptor"
REACT:R-MMU-2423785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR:atREs binds apoE and HSPG (Mus musculus)
RHEA:27787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CoA + NAD(+) => CO2 + NADH + succinyl-CoA
RHEA:64211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-glutamine + H2O <=> a fatty acid + L-glutamine
GO:0015293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	symport
GO:0015293	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cotransporter activity
GO:0015293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	symporter activity
GO:0015293	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	porter activity
RHEA:38219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-BTA-6799178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)
GO:0016889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endodeoxyribonuclease activity, producing 3'-phosphomonoesters
GO:0016889	skos:prefLabel	"Endodeoxyribonucleases producing other than 5'-phosphomonoesters"
GO:0016889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters
GO:0016889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Endodeoxyribonucleases producing other than 5'-phosphomonoesters"
REACT:R-DME-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Drosophila melanogaster)
RHEA:26026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8'-apo-beta-carotenol + O2 <=> (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal
REACT:R-BTA-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)
RHEA:53856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + ursocholate = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH
RHEA:16399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + D-glucose 1,6-bisphosphate => 2 D-glucopyranose 1-phosphate
REACT:R-MMU-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Mus musculus)
RHEA:28627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + solavetivol = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone
RHEA:56061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + hnu => CO2 + pentadecane
REACT:R-SCE-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Saccharomyces cerevisiae)
REACT:R-GGA-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Gallus gallus)
REACT:R-HSA-9698179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)
REACT:R-GGA-5654510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 binds SPRED1/2 (Gallus gallus)
REACT:R-HSA-2161733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is dehydrated to PGJ2 (Homo sapiens)
REACT:R-RNO-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Rattus norvegicus)
RHEA:31301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + perillate => H2O + NAD(+) + perillyl aldehyde
RHEA:54962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + dinor-OPDA-CoA + diphosphate => ATP + CoA + dinor-OPDA
REACT:R-DDI-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Dictyostelium discoideum)
RHEA:55066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanoate + CoA + H(+) => 4-methylpentanoyl-CoA + H2O
RHEA:45740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ectoine hydroxylase"
RHEA:45740	skos:altLabel	"ectoine dioxygenase"
RHEA:45740	skos:prefLabel	"ectoine hydroxylase"
RHEA:45740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate
RHEA:53854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxo-glycodeoxycholate + H(+) + NADH => glycocholate + NAD(+)
REACT:R-MMU-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Mus musculus)
REACT:R-BTA-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Bos taurus)
RHEA:55372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl (-)-jasmonate = H(+) + jasmonate + methanol
REACT:R-DRE-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Danio rerio)
REACT:R-MMU-8942302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP13 cleaves OPTC (Mus musculus)
REACT:R-CEL-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-XTR-3465459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Xenopus tropicalis)
REACT:R-SPO-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Schizosaccharomyces pombe)
REACT:R-DRE-1667005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Danio rerio)
REACT:R-DRE-2160932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 binds phosphorylated PARD6A (Danio rerio)
REACT:R-SSC-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)
REACT:R-HSA-8932633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Homo sapiens)
RHEA:15753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylosuccinate synthase"
RHEA:15753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate
RHEA:15753	skos:prefLabel	"adenylosuccinate synthase"
RHEA:15753	skos:altLabel	"succinoadenylic kinosynthetase"
RHEA:15753	skos:altLabel	"IMP--aspartate ligase"
RHEA:15753	skos:altLabel	"adenylosuccinate synthetase"
RHEA:54767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)
REACT:R-BTA-2395364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP4 binds TGF-Beta-1 (Bos taurus)
REACT:R-DDI-5696365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Dictyostelium discoideum)
REACT:R-MMU-1470010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs (Mus musculus)
GO:0050460	skos:altLabel	"hydroxylamine reductase"
GO:0050460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylamine reductase (NADH) activity
GO:0050460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylamine reductase (NADH2)
GO:0050460	skos:altLabel	"NADH-hydroxylamine reductase"
GO:0050460	skos:prefLabel	"hydroxylamine reductase (NADH)"
GO:0050460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonium dehydrogenase activity
GO:0050460	skos:altLabel	"ammonium dehydrogenase"
GO:0050460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonium:NAD+ oxidoreductase activity
GO:0050460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-hydroxylamine reductase activity
GO:0050460	skos:altLabel	"NADH:hydroxylamine oxidoreductase"
GO:0050460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2:hydroxylamine oxidoreductase activity
GO:0050460	skos:altLabel	"N-hydroxy amine reductase"
GO:0050460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-hydroxy amine reductase activity
GO:0050460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxylamine reductase (NADH)"
GO:0050460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + NH4(+) = 2 H(+) + hydroxylamine + NADH
GO:0050460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:hydroxylamine oxidoreductase activity
REACT:R-BTA-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Bos taurus)
REACT:R-RNO-8987236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Rattus norvegicus)
REACT:R-HSA-210920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEUROG3-dependent synthesis of NEUROD1 (Homo sapiens)
REACT:R-HSA-157100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds JAG1 (Homo sapiens)
RHEA:60006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O
RHEA:37203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
RHEA:35570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine <=> (9Z,12Z)-octadecadienoate + ethanolamine
RHEA:69037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-androstane-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5beta-androstane-17-one + NADP(+)
REACT:R-XTR-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Xenopus tropicalis)
REACT:R-MMU-8876837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB21 GEFs exchange GTP for GDP on RAB21 (Mus musculus)
REACT:R-CFA-168412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP elicits a NOD2 response (Canis familiaris)
RHEA:43081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-110251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of hypoxanthine by MPG glycosylase (Homo sapiens)
RHEA:62021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sitosteryl 3-beta-D-glucoside => D-glucose + sitosterol
REACT:R-GGA-1562640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LNK binds to p-KIT and inhibit downstream signaling (Gallus gallus)
RHEA:72930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV
RHEA:14815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-2-aminohexano-6-lactam => L-2-aminohexano-6-lactam
REACT:R-CFA-4224014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by ADAM10, ADAM15 (Canis familiaris)
EC:3.5.5.1	skos:prefLabel	"nitrilase"
EC:3.5.5.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrilase"
REACT:R-MMU-6799179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Mus musculus)
RHEA:56164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:56829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6-trichlorohydroquinone + chloride + glutathione disulfide => 2,3,5,6-tetrachlorohydroquinone + 2 glutathione
RHEA:56246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein] => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]
REACT:R-CFA-8943041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)
RHEA:49087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:41228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelate + O2 => 4-hydroxyphenylglyoxylate + H2O2
RHEA:42426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-methylmalate => 2-methylmaleate + H2O
REACT:R-GGA-9009541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds to TFF1 gene promoter (Gallus gallus)
RHEA:50376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ceramide(in) + ATP + H2O = a ceramide(out) + ADP + H(+) + phosphate
REACT:R-DRE-8950456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B dimerizes (Danio rerio)
REACT:R-DME-3769394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CBY1 (Drosophila melanogaster)
RHEA:15380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4,5-dihydroxypentane-2,3-dione + ATP <=> (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)
REACT:R-SSC-77283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Sus scrofa)
RHEA:28921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + L-glutamate(in) => 4-aminobutanoate(in) + L-glutamate(out)
RHEA:44351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide B + H(+) + phosphate
RHEA:22670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + lipid A disaccharide (E. coli) + UDP => 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
REACT:R-RNO-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Rattus norvegicus)
REACT:R-BTA-5685649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPAs translocate from ER membrane to extracellular region (Bos taurus)
REACT:R-GGA-5684868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPC translocates from ER membrane to multivesicle body (Gallus gallus)
RHEA:72317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(out) + leukotriene C4(in) => glutathione(in) + leukotriene C4(out)
REACT:R-HSA-9759334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds the SRXN1 gene (Homo sapiens)
REACT:R-BTA-3225851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin and activate MAP3K5 (Bos taurus)
REACT:R-RNO-76373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxylation of 4-aminobiphenyl (Rattus norvegicus)
REACT:R-HSA-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Homo sapiens)
RHEA:49514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphinomethylisomalate => 2-(phosphinatomethylidene)butanedioate + H2O
GO:0102154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity
RHEA:24279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + diphosphate <=> acetyl phosphate + phosphate
RHEA:28607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Dictyostelium discoideum)
RHEA:48261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1 => CMP + ganglioside GD1a + H(+)
REACT:R-XTR-9629216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Xenopus tropicalis)
REACT:R-SSC-8983307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL15RA (Sus scrofa)
RHEA:65796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:34376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanamide + H2O => 4-guanidinobutanoate + NH4(+)
REACT:R-MMU-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Mus musculus)
RHEA:64554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:30691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + methanol = formaldehyde + 2 H2O
REACT:R-SPO-5689861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of XPA and release of CAK  (Schizosaccharomyces pombe)
RHEA:20796	skos:altLabel	"D-ribose isomerase"
RHEA:20796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose = D-ribulose
RHEA:20796	skos:prefLabel	"ribose isomerase"
RHEA:20796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribose isomerase"
REACT:R-GGA-4655355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Gallus gallus)
RHEA:70170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)
REACT:R-HSA-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Homo sapiens)
RHEA:11518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + succinate => H2O + succinyl-CoA
RHEA:68309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate
RHEA:48458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O
GO:0102690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyladenine UDP glycosyltransferase activity
RHEA:36300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + ATP + CoA => (E)-caffeoyl-CoA + AMP + diphosphate
REACT:R-DME-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Drosophila melanogaster)
RHEA:16193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)
REACT:R-PFA-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)
EC:2.7.5.-	skos:prefLabel	"Phosphotransferases with regeneration of donors, apparently catalyzing intramolecular transfers"
EC:2.7.5.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphotransferases with regeneration of donors, apparently catalyzing intramolecular transfers"
RHEA:14156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine <=> 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP
REACT:R-RNO-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Rattus norvegicus)
GO:0004954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostanoid receptor activity
GO:0047832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-pinitol dehydrogenase activity
GO:0047832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity
GO:0047832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity
REACT:R-XTR-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Xenopus tropicalis)
REACT:R-HSA-9708536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 translocates from the cytosol to the nucleoplasm (Homo sapiens)
REACT:R-HSA-204779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang1 (Homo sapiens)
REACT:R-XTR-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Xenopus tropicalis)
REACT:R-MMU-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Mus musculus)
REACT:R-RNO-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Rattus norvegicus)
REACT:R-SSC-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Sus scrofa)
RHEA:12576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"procollagen glucosyltransferase"
RHEA:12576	skos:altLabel	"galactosylhydroxylysine-glucosyltransferase"
RHEA:12576	skos:prefLabel	"procollagen glucosyltransferase"
RHEA:12576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose = (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP
RHEA:21511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + H2O <=> H(+) + hexadecanoate + retinol
REACT:R-BTA-9668395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CC2D1B (Bos taurus)
REACT:R-SCE-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Saccharomyces cerevisiae)
RHEA:41770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GT1a (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E))
RHEA:28179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => colnelenate + H2O
REACT:R-CEL-9727198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B exchanges K+ for H+ (Caenorhabditis elegans)
RHEA:29030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + L-glutamate(in) <=> 2 H(+)(out) + L-glutamate(out)
RHEA:64027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) <=> H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)
REACT:R-HSA-9755413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 8 binds IL17RA (Homo sapiens)
REACT:R-CFA-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
RHEA:20470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP => D-ribose 5-phosphate + hypoxanthine
REACT:R-HSA-909729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JAK kinases (Homo sapiens)
REACT:R-MMU-2025723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the N-glycan precursor (Mus musculus)
REACT:R-SSC-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Sus scrofa)
REACT:R-SSC-5362386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Hh (Sus scrofa)
RHEA:23996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)
REACT:R-CFA-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Canis familiaris)
REACT:R-HSA-1564169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VIII degradation by MMP1 (Homo sapiens)
REACT:R-MMU-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Mus musculus)
RHEA:34378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanamide + H2O <=> 4-guanidinobutanoate + NH4(+)
GO:0003995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl coenzyme A dehydrogenase activity
GO:0003995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acyl coenzyme A dehydrogenase activity
GO:0003995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl CoA dehydrogenase activity
GO:0003995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA reductase activity
GO:0003995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA dehydrogenase activity
GO:0003995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty-acyl-CoA dehydrogenase activity
GO:0003995	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	general acyl CoA dehydrogenase activity
REACT:R-CFA-5229010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-27 of histone H3 (H3R26) (Canis familiaris)
RHEA:46417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-6811414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF (Canis familiaris)
REACT:R-SSC-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Sus scrofa)
REACT:R-DRE-5205799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Danio rerio)
REACT:R-SSC-5244669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Sus scrofa)
RHEA:12918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha(S)-strictosidine + H2O => D-glucose + strictosidine aglycone
GO:0061810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD glycohydrolase activity
REACT:R-CFA-9678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 binds S1PR1 agonists (Canis familiaris)
RHEA:27467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-glycero-beta-D-manno-heptose + diphosphate => ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+)
REACT:R-CFA-9645406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Canis familiaris)
GO:0004936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-adrenergic receptor activity
GO:0004936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha adrenoceptor
REACT:R-CFA-9664855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Canis familiaris)
REACT:R-BTA-5423653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGST trimers transfer GS from GSH to AFXBO and AFNBO (Bos taurus)
RHEA:44204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoate + ATP + CoA = 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate
RHEA:19515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-citrulline + phosphate => carbamoyl phosphate + L-ornithine
RHEA:24615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + NAD(+) <=> estrone + H(+) + NADH
REACT:R-SPO-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Schizosaccharomyces pombe)
REACT:R-BTA-4755536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates RELA with SUMO3 (Bos taurus)
GO:0008175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)
GO:0008175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA methyltransferase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrofolate reduction
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrofolate dehydrogenase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydrofolate reductase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrofolic reductase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHFR
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pteridine reductase:dihydrofolate reductase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrofolic acid reductase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folic acid reductase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidylate synthetase-dihydrofolate reductase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dihydrofolate reductase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrofolate reductase:thymidylate synthase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folic reductase activity
GO:0004146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrofolate reductase activity
GO:0051509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tomatidine UDP-glucosyltransferase activity
REACT:R-GGA-5692755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates MAPK6 (Gallus gallus)
RHEA:53836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]
RHEA:53836	skos:altLabel	"UDP-3-O-[3-hydroxymyristoyl]-D-glucosamine N-acyltransferase"
RHEA:53836	skos:prefLabel	"UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase"
RHEA:53836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase"
RHEA:53836	skos:altLabel	"UDP-3-O-acyl-glucosamine N-acyltransferase"
RHEA:35907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-CEL-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Caenorhabditis elegans)
REACT:R-RNO-8849878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSD-95 binds NMDA receptor (Rattus norvegicus)
REACT:R-CFA-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Canis familiaris)
REACT:R-GGA-174731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of newly synthesized ApoB-48 (Gallus gallus)
REACT:R-MMU-4086088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO1 (Mus musculus)
RHEA:23154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + NAD(+) => a ubiquinone + H(+) + NADH
RHEA:45410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + NAD(+) => (2E)-dodecenoyl-CoA + H(+) + NADH
REACT:R-BTA-9603420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 promotes SRC autophosphorylation (Bos taurus)
REACT:R-RNO-622325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)
RHEA:60763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin II
RHEA:50259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:58127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde
REACT:R-XTR-445752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Xenopus tropicalis)
REACT:R-HSA-9748979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Homo sapiens)
REACT:R-DRE-8983983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Danio rerio)
RHEA:54245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-MMU-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Mus musculus)
REACT:R-SSC-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Sus scrofa)
REACT:R-MMU-168405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD oligomer recruites RIP2 (RICK) (Mus musculus)
REACT:R-DRE-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Danio rerio)
REACT:R-MMU-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
RHEA:41417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:11775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH
RHEA:65102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an hexadecanoyl-acylglycerol + CoA => a 1-acylglycerol + hexadecanoyl-CoA
RHEA:69623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-D-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-D-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
RHEA:47422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-glutaconyl-CoA + AH2 => A + glutaryl-CoA
RHEA:22223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate <=> diphosphate + ent-kaur-16-ene
REACT:R-MMU-8983834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Mus musculus)
GO:0016680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor
GO:0016680	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0016680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
REACT:R-SSC-6782138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC5 and RPA bind TC-NER site (Sus scrofa)
RHEA:70177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + D-galactose => beta-D-glucosyl-(1->4)-D-galactose + phosphate
RHEA:50508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]
REACT:R-HSA-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Homo sapiens)
REACT:R-SSC-9706364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of ubiquitinated FLT3 (Sus scrofa)
RHEA:16459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)
REACT:R-HSA-3640862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase binds AXIN (Homo sapiens)
GO:0080115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin XI tail binding
RHEA:45982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+) => 3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2
RHEA:72588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + ATP + CoA => (E)-sinapoyl-CoA + AMP + diphosphate
RHEA:50515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]
REACT:R-GGA-8987236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Gallus gallus)
REACT:R-SPO-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Schizosaccharomyces pombe)
RHEA:33934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + O2 <=> (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal
GO:1903962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonate transmembrane transporter activity
GO:1903962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonic acid transporter activity
GO:1903962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonate transporter activity
REACT:R-HSA-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Homo sapiens)
REACT:R-DDI-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Dictyostelium discoideum)
RHEA:54831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + H(+) + NADPH + O2 <=> formaldehyde + H2O + methylamine + NADP(+)
RHEA:54153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH
REACT:R-BTA-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Bos taurus)
RHEA:34812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetrahydrocurcumin => dihydrocurcumin + H(+) + NADPH
RHEA:30009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-arabinose(in) + phosphate => ATP + H2O + L-arabinose(out)
REACT:R-DDI-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Dictyostelium discoideum)
RHEA:56718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]
EC:3.4.21.34	skos:altLabel	"serum kallikrein"
EC:3.4.21.34	skos:altLabel	"kininogenin"
EC:3.4.21.34	skos:prefLabel	"plasma kallikrein"
EC:3.4.21.34	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plasma kallikrein"
REACT:R-HSA-8937037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
REACT:R-MMU-77329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Mus musculus)
RHEA:69931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine(out) + Na(+)(out) = inosine(in) + Na(+)(in)
REACT:R-BTA-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Bos taurus)
REACT:R-DME-432361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PER is degraded by the 26S proteasome (Drosophila melanogaster)
REACT:R-XTR-211873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)
RHEA:30017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose
GO:0050554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abietadiene synthase activity
GO:0050554	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	copalyl-diphosphate diphosphate-lyase (cyclizing)
GO:0050554	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)
GO:0050554	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	abietadiene cyclase activity
REACT:R-MMU-5624954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INPP5E translocates to the primary cilium (Mus musculus)
RHEA:27682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dTDP = ADP + dTTP
REACT:R-MMU-8938770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Mus musculus)
REACT:R-MMU-1433508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC alpha interacts with and phosphorylates KIT (Mus musculus)
REACT:R-DRE-3791319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NID1 degradation by MMP19 (Danio rerio)
RHEA:10565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate 4-methyl ester => H(+) + methanol + oxaloacetate
RHEA:46579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + sitosterol <=> 2 H2O + NADP(+) + stigmasterol
REACT:R-DME-193763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)
RHEA:24203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + H(+) <=> aniline + CO2
RHEA:60251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]
REACT:R-BTA-9691174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the ER membrane (Bos taurus)
REACT:R-CFA-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Canis familiaris)
REACT:R-SPO-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Schizosaccharomyces pombe)
REACT:R-GGA-5654163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds PLCG1 (Gallus gallus)
RHEA:28010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanoyl-CoA + succinate = propanoate + succinyl-CoA
RHEA:23382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-DRE-9700171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates PLCG1 (Danio rerio)
RHEA:50724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxyphenylacetaldehyde oxime = (Z)-(4-hydroxyphenyl)acetaldehyde oxime
RHEA:61755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolbioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside B + UDP
REACT:R-CFA-1602473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP1 (Canis familiaris)
RHEA:35965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A
REACT:R-MMU-430021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAN2-PAN3 complex partially deadenylates mRNA (Mus musculus)
RHEA:66076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-2-aminopentanoate
REACT:R-RNO-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Rattus norvegicus)
RHEA:18159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate
GO:0043738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced coenzyme F420 dehydrogenase activity
GO:0043738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-dihydrocoenzyme F420 dehydrogenase activity
GO:0043738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420H2 dehydrogenase activity
RHEA:45508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]
REACT:R-SSC-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Sus scrofa)
REACT:R-GGA-9023632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Gallus gallus)
REACT:R-DME-354273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene (Drosophila melanogaster)
REACT:R-HSA-9694331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3-4 is glycosylated (Homo sapiens)
RHEA:70992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-mannopyranose(in) => H(+)(out) + L-mannopyranose(out)
REACT:R-HSA-1912412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 mRNA translation controlled by miRNAs (Homo sapiens)
REACT:R-HSA-2247514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARF1:ligand is endocytosed (Homo sapiens)
REACT:R-HSA-110363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)
REACT:R-GGA-977375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR1 binds C3bBb/C4bC2a (Gallus gallus)
EC:1.7.1.14	skos:prefLabel	"nitric oxide reductase [NAD(P)(+), nitrous oxide-forming]"
EC:1.7.1.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitric oxide reductase [NAD(P)(+), nitrous oxide-forming]"
EC:1.7.1.14	skos:altLabel	"cytochrome P450nor"
EC:1.7.1.14	skos:altLabel	"NOR"
EC:1.7.1.14	skos:altLabel	"fungal nitric oxide reductase"
REACT:R-CFA-193981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 oxidises 17HPROG (Canis familiaris)
RHEA:23885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide + S-adenosyl-L-methionine => 1-methylnicotinamide + S-adenosyl-L-homocysteine
RHEA:68121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a fatty acyl-CoA => a triacylglycerol + CoA
REACT:R-DDI-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Dictyostelium discoideum)
REACT:R-MMU-140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Mus musculus)
REACT:R-BTA-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Bos taurus)
REACT:R-HSA-77321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Homo sapiens)
REACT:R-HSA-8949145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space (Homo sapiens)
REACT:R-SSC-8869627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NR to yield NMN (Sus scrofa)
RHEA:21207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester
REACT:R-HSA-448957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of p38 MAPK with JLP (Homo sapiens)
REACT:R-RNO-191983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)
RHEA:31992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + sesquithujene
REACT:R-GGA-182988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty lures CBL away from EGFR (Gallus gallus)
REACT:R-SCE-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Saccharomyces cerevisiae)
REACT:R-GGA-2395324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyrrole cross-links (Gallus gallus)
REACT:R-SSC-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Sus scrofa)
REACT:R-HSA-195408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Homo sapiens)
RHEA:52909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dimethylallyl-4-hydroxyphenylpyruvate + O2 => 3-dimethylallyl-4-hydroxymandelate + CO2
RHEA:10765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate
REACT:R-RNO-5654697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
RHEA:26460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + FMN + 2 H(+) + H2O + nitrite => ethylnitronate + FMNH2 + O2
REACT:R-HSA-8954208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:ESR1 binds PGR gene promoter (Homo sapiens)
RHEA:48023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + H2O <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose
REACT:R-HSA-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Homo sapiens)
REACT:R-CFA-2396079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds Plasminogen activator inhibitor- 1 (Canis familiaris)
REACT:R-MMU-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Mus musculus)
RHEA:47189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol => hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]
REACT:R-XTR-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Xenopus tropicalis)
RHEA:65515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 <=> 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2
REACT:R-BTA-202727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaMbeta2 (MAC1) binds JAM3 (Bos taurus)
GO:1901474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	azole transporter activity
GO:1901474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	azole transmembrane transporter activity
REACT:R-HSA-8854759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D14 binds RAB11 and ULK1 (Homo sapiens)
RHEA:49141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-8848023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds STAP2 (Rattus norvegicus)
RHEA:47720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + isoguanine = NH4(+) + xanthine
REACT:R-RNO-5634729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Rattus norvegicus)
GO:0030504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKH transports PPi from cytosol to extracellular region (Homo sapiens)
GO:0030504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic pyrophosphate transporter activity
GO:0030504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic diphosphate transmembrane transporter activity
RHEA:44418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O
RHEA:53844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate + NAD(+) = 7-oxoglycolithocholate + H(+) + NADH
REACT:R-DDI-349444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of COP1 at Ser-387  by ATM (Dictyostelium discoideum)
REACT:R-DDI-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Dictyostelium discoideum)
REACT:R-HSA-8954179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)
REACT:R-RNO-5218812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates PAK2 (Rattus norvegicus)
RHEA:46755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Gallus gallus)
REACT:R-DDI-4570553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO2,3 (Dictyostelium discoideum)
REACT:R-HSA-2316349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RALA:GTP binds MYO1C:CALM1 and activates MYO1C (Homo sapiens)
GO:0018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity
REACT:R-MMU-167433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta-gamma subunits rebind the alpha-GDP subunit (Mus musculus)
RHEA:65899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-kynurenine <=> glycine + H2O + kynurenate
REACT:R-DRE-5607751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes (Danio rerio)
RHEA:20281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate = (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)
GO:0090556	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylserine-translocating ATPase activity
GO:0090556	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-dependent phosphatidylserine transporter activity
GO:0090556	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-coupled phosphatidylserine transporter activity
GO:0090556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate
GO:0090556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylserine floppase activity (cytosolic to exoplasmic leaftlet)
GO:0090556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylserine floppase activity
REACT:R-HSA-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Homo sapiens)
REACT:R-CFA-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Canis familiaris)
RHEA:19511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-erythro-biopterin + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)
GO:0102007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-L-homoserine-lactone lactonohydrolase activity
REACT:R-HSA-171291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Folding and Oligomerization of ENV glycoprotein (Homo sapiens)
REACT:R-CFA-5685156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2 (Canis familiaris)
RHEA:32339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-thujan-3-ol + NADP(+) = (+)-thujan-3-one + H(+) + NADPH
REACT:R-SSC-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Sus scrofa)
GO:0047457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity
GO:0047457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)
GO:0047457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,4-glucan exo-lyase activity
GO:0047457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-(1->4)-alpha-D-glucan lyase activity
GO:0047457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-(1,4)-alpha-D-glucan lyase activity
GO:0047457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-alpha-1,4-glucan lyase activity
GO:0047457	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-1,4-glucan lyase activity
GO:0047457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity
RHEA:66384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol = scalar-17(25)-en-19-ol
REACT:R-DRE-5229010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-27 of histone H3 (H3R26) (Danio rerio)
REACT:R-RNO-9025996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Rattus norvegicus)
REACT:R-DRE-193695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK interacts with TRAF6 (Danio rerio)
RHEA:53991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-threonyl-[myosin light chain] <=> L-threonyl-[myosin light chain] + phosphate
RHEA:22050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate
REACT:R-CFA-70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Canis familiaris)
GO:0002094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyprenyltransferase activity
RHEA:35476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'S)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + H(+) + NADH
REACT:R-CFA-8982641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Canis familiaris)
GO:0034598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphothreonine lyase activity
GO:1901611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylglycerol binding
RHEA:40066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA
RHEA:58265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside
RHEA:44267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA
RHEA:36121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-methyl gibberellin A9 + S-adenosyl-L-homocysteine => gibberellin A9 + S-adenosyl-L-methionine
REACT:R-RNO-1855176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Rattus norvegicus)
REACT:R-HSA-4551655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)
RHEA:10563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O <=> 2,5-dioxopentanoate + NH4(+)
RHEA:59415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuccinamate + H2O <=> NH4(+) + oxaloacetate
REACT:R-CFA-392202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 12:Gi complex (Canis familiaris)
REACT:R-DME-5205672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncleaved Pink1 accumulates in damaged mitochondria (Drosophila melanogaster)
REACT:R-CFA-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Canis familiaris)
REACT:R-CFA-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Canis familiaris)
RHEA:38083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-DRE-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Danio rerio)
GO:0102724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:curcumin monoglucoside glucosyltransferase activity
REACT:R-CFA-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Canis familiaris)
REACT:R-CFA-2022399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Canis familiaris)
GO:0098782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanosensitived potassium channel activity
GO:0098782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanically-gated potassium channel activity
RHEA:50381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 malonyl-CoA => 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA
REACT:R-RNO-5649800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)
RHEA:24694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + NADP(+) + trans-anol = NADPH + trans-coumaryl acetate
RHEA:24694	skos:altLabel	"T-anol/isoeugenol synthase 1"
RHEA:24694	skos:prefLabel	"isoeugenol synthase"
RHEA:24694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoeugenol synthase"
RHEA:24694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + NADP(+) + trans-isoeugenol = (E)-coniferyl acetate + NADPH
RHEA:22734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol + CO2 => 4-hydroxyphenylacetate + H(+)
RHEA:17007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phospho-alpha-D-glucuronate + ADP + H(+) => ATP + D-glucuronate
REACT:R-SSC-163843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-GAS6 to GAS6 (Sus scrofa)
GO:0032558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenyl deoxyribonucleotide binding
RHEA:38421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O
RHEA:66354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+)
REACT:R-DRE-1449687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticosteroids bind to CBG in blood (Danio rerio)
GO:0106312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH
GO:0106312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydrofolate reductase NADH activity
REACT:R-DRE-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Danio rerio)
REACT:R-RNO-6799495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYCTK phosphorylates DGA to 3PDGA (Rattus norvegicus)
REACT:R-HSA-9665311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 T798M does not bind afatinib (Homo sapiens)
REACT:R-MMU-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Mus musculus)
RHEA:16485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"imidazoleacetate--phosphoribosyldiphosphate ligase"
RHEA:16485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate = 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate
RHEA:16485	skos:altLabel	"5-phosphoribosylimidazoleacetate synthetase"
RHEA:16485	skos:prefLabel	"imidazoleacetate--phosphoribosyldiphosphate ligase"
REACT:R-BTA-8851899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Bos taurus)
RHEA:49407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-mannose
REACT:R-HSA-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Homo sapiens)
RHEA:68665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-DRE-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Danio rerio)
REACT:R-CFA-8941312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Canis familiaris)
REACT:R-BTA-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Bos taurus)
REACT:R-GGA-388560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA,EDNRB bind EDNs (Gallus gallus)
RHEA:17787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + CO2 => H(+) + L-glutamate
RHEA:47843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate
REACT:R-RNO-6799203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Rattus norvegicus)
REACT:R-DRE-2484822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore assembly (Danio rerio)
REACT:R-XTR-9690493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors on endosomes (Xenopus tropicalis)
REACT:R-XTR-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Xenopus tropicalis)
REACT:R-BTA-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Bos taurus)
RHEA:20047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + malonate + NADH => 3-oxopropanoate + H2O + NAD(+)
RHEA:58647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine <=> (9Z,12Z,15Z)-octadecatrienamide + glyoxylate
REACT:R-CFA-388814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds CD28 (Canis familiaris)
REACT:R-RNO-965067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THTPA:Mg2+ hydrolyzes ThTP to TDP (Rattus norvegicus)
RHEA:67430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O
REACT:R-DRE-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Danio rerio)
RHEA:17571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dehydroreticuline + H(+) + NADPH => (R)-reticuline + NADP(+)
RHEA:69405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil(in) => uracil(out)
REACT:R-DRE-9624800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LBR (Danio rerio)
REACT:R-SSC-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Sus scrofa)
REACT:R-MMU-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Mus musculus)
REACT:R-MMU-380294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of C-Nap-1 from centrosomes (Mus musculus)
RHEA:26199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammeline + NH4(+) => H2O + melamine
REACT:R-RNO-8853737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Rattus norvegicus)
RHEA:12841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxamine--pyruvate transaminase"
RHEA:12841	skos:altLabel	"Pyridoxamine--pyruvate aminotransferase"
RHEA:12841	skos:prefLabel	"pyridoxamine--pyruvate transaminase"
RHEA:12841	skos:altLabel	"Pyridoxamine-pyruvic transaminase"
RHEA:12841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine + pyruvate = L-alanine + pyridoxal
REACT:R-XTR-6788999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HV1-mediated H+ transfer (Xenopus tropicalis)
GO:0019211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatase activator activity
REACT:R-HSA-8932084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and ESR1 bind the AXIN1 gene (Homo sapiens)
RHEA:59906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + octanoate => H2O + NADP(+) + octanal
RHEA:72726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-xylose(in) + UMP(out) <=> UDP-alpha-D-xylose(out) + UMP(in)
REACT:R-GGA-2022398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Gallus gallus)
REACT:R-CFA-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Canis familiaris)
GO:0016929	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SUSP
GO:0016929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deSUMOylase activity
GO:0016929	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ULP
GO:0016929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-specific isopeptidase activity
GO:0016929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-specific protease activity
REACT:R-CFA-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Canis familiaris)
RHEA:45835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH
RHEA:52498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0043818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-3B synthase activity
GO:0043818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)
GO:0043818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobG
GO:0043818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	precorrin-3X synthase activity
REACT:R-GGA-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Gallus gallus)
RHEA:57954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + H2O + NAD(+) => H(+) + NADH + O2 + phenol
RHEA:14079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + pyruvate => 3-oxopropanoate + L-alanine
GO:0018467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde dehydrogenase activity
GO:0018467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formaldehyde:NAD+ oxidoreductase activity
GO:0018467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-independent formaldehyde dehydrogenase activity
REACT:R-MMU-6799246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates TP53 (Mus musculus)
REACT:R-SSC-1855219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Sus scrofa)
REACT:R-CFA-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Canis familiaris)
RHEA:46253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0044104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate:NAD+ 5-oxidoreductase activity
GO:0044104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxovalerate dehydrogenase (NAD+) activity
GO:0044104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate dehydrogenase (NAD+) activity
REACT:R-HSA-2022073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen triple helix formation (Homo sapiens)
RHEA:43806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol
GO:0004895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesion receptor activity
RHEA:29948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-rhamnopyranose(in) => H(+)(out) + L-rhamnopyranose(out)
REACT:R-MMU-5672980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF complex (Mus musculus)
RHEA:13443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NH4(+) + pyruvate + sulfite => H2O + L-cysteate
RHEA:62570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + S-benzyl-L-cysteine => H2O + S-benzyl-L-cysteinylglycine
REACT:R-DME-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Drosophila melanogaster)
RHEA:22630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate
EC:1.2.1.-	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
EC:1.2.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
RHEA:29658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(in) <=> L-cysteine(out)
RHEA:40893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-MMU-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Mus musculus)
RHEA:51560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-bulbocapnine + S-adenosyl-L-methionine = (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Canis familiaris)
REACT:R-SSC-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Sus scrofa)
RHEA:37191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-AMP + H2O = adenosine 2'-phosphate + H(+)
REACT:R-CFA-1471322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins are secreted (Canis familiaris)
RHEA:71744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + hexanedioate(in) => 2-oxoglutarate(in) + hexanedioate(out)
GO:0016671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a disulfide as acceptor"
GO:0016671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor
GO:0016671	skos:prefLabel	"With a disulfide as acceptor"
GO:0016671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
REACT:R-HSA-9623427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
REACT:R-DRE-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Danio rerio)
REACT:R-DDI-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Dictyostelium discoideum)
RHEA:16715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + H(+) + succinate => H2O + S-succinylglutathione
REACT:R-HSA-388560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA,EDNRB bind EDNs (Homo sapiens)
REACT:R-CFA-6786190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMBL hydrolyses OM to OLMS (Canis familiaris)
RHEA:32734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)
RHEA:52090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA
RHEA:68642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + limonene => (2E)-geranyl diphosphate
RHEA:22594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,15Z)-12-oxophytodienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate
REACT:R-SSC-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Sus scrofa)
REACT:R-DRE-428262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Danio rerio)
REACT:R-MMU-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Mus musculus)
REACT:R-RNO-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Rattus norvegicus)
RHEA:35652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + a fatty acyl-CoA => an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)
RHEA:54477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)
RHEA:34335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]
REACT:R-HSA-5692775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Homo sapiens)
REACT:R-SCE-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Saccharomyces cerevisiae)
RHEA:22803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloeucalenol <=> obtusifoliol
RHEA:42999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> (R)-cembrene A + diphosphate
REACT:R-HSA-437234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heat-Stable Antigen binds L1 (Homo sapiens)
GO:0140090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	membrane curvature sensor activity
RHEA:52045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mogrol + UDP-alpha-D-glucose => H(+) + mogroside IE + UDP
REACT:R-HSA-205289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of KIT (Homo sapiens)
REACT:R-XTR-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Xenopus tropicalis)
GO:0018447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloral hydrate dehydrogenase activity
REACT:R-XTR-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Xenopus tropicalis)
GO:0080071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity
RHEA:20946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + theobromine
RHEA:67860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-8850326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds self-lipid-based antigen via CD1 (Canis familiaris)
RHEA:43435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + 2 Fe(III)-[cytochrome c] <=> butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)
GO:0099100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein gated cation channel activity
REACT:R-RNO-1889981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Rattus norvegicus)
REACT:R-HSA-5688837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)
RHEA:19000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + phosphocholine <=> CDP-choline + diphosphate
REACT:R-DDI-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Dictyostelium discoideum)
REACT:R-CEL-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Caenorhabditis elegans)
REACT:R-SCE-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Saccharomyces cerevisiae)
RHEA:25886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-succinyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-succinyl-L-ornithine
RHEA:49653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protoviolaceinate => H2O + NAD(+) + violaceinate
REACT:R-MMU-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Mus musculus)
RHEA:65403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + butanoyl-CoA <=> butyl butanoate + CoA
REACT:R-RNO-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Rattus norvegicus)
EC:3.4.12.-	skos:prefLabel	"Peptidylamino-acid hydrolases or acylamino-acid hydrolases"
EC:3.4.12.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Peptidylamino-acid hydrolases or acylamino-acid hydrolases"
RHEA:32848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol
RHEA:39072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanedioyl-CoA + O2 => (2E)-dodecenedioyl-CoA + H2O2
REACT:R-SSC-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Sus scrofa)
REACT:R-MMU-5690701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 binds p-CD22 (Mus musculus)
GO:0004462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactoylglutathione lyase activity
GO:0004462	skos:altLabel	"glyoxalase I"
GO:0004462	skos:altLabel	"ketone-aldehyde mutase"
GO:0004462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity
GO:0004462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketone-aldehyde mutase activity
GO:0004462	skos:prefLabel	"lactoylglutathione lyase"
GO:0004462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldoketomutase activity
GO:0004462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylglyoxalase activity
GO:0004462	skos:altLabel	"(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing)"
GO:0004462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxalase I activity
GO:0004462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-lactoylglutathione = glutathione + methylglyoxal
GO:0004462	skos:altLabel	"methylglyoxalase"
GO:0004462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)
GO:0004462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactoylglutathione lyase"
GO:0004462	skos:altLabel	"aldoketomutase"
GO:0004462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylase I
REACT:R-BTA-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Bos taurus)
REACT:R-DRE-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Danio rerio)
GO:0018690	skos:altLabel	"4-methoxybenzoate O-demethylase"
GO:0018690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxybenzoate monooxygenase (O-demethylating) activity
GO:0018690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-anisic O-demethylase activity
GO:0018690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxybenzoate monooxygenase activity
GO:0018690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)
GO:0018690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxybenzoate + AH2 + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O
GO:0018690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methoxybenzoate 4-monooxygenase (O-demethylating)
GO:0018690	skos:prefLabel	"4-methoxybenzoate monooxygenase (O-demethylating)"
GO:0018690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methoxybenzoate O-demethylase activity
GO:0018690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	piperonylate-4-O-demethylase activity
GO:0018690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-methoxybenzoate monooxygenase (O-demethylating)"
REACT:R-RNO-448629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33 binds IL1RL1 (Rattus norvegicus)
REACT:R-GGA-8855617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Gallus gallus)
REACT:R-MMU-191656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Closure of gap junction (Mus musculus)
REACT:R-GGA-2201293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TLR4:LY96:LPS:CD14 (Gallus gallus)
REACT:R-RNO-879201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bcl-2 and Bcl-XL bind NLRP1 (Rattus norvegicus)
REACT:R-HSA-266299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds membrane-associated free cholesterol and phospholipids (Homo sapiens)
REACT:R-HSA-1225956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)
REACT:R-MMU-111746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Mus musculus)
GO:0070039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (guanosine-2'-O-)-methyltransferase activity
REACT:R-GGA-4420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 disassociates from VEGFR2 and translocate to PM (Gallus gallus)
REACT:R-DRE-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Danio rerio)
REACT:R-BTA-5651654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Bos taurus)
REACT:R-CFA-5687640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Canis familiaris)
RHEA:41809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoyl-[ACP] => (2E)-butenoyl-[ACP] + H2O
REACT:R-RNO-1169398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host protein filamin B (Rattus norvegicus)
REACT:R-MMU-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Mus musculus)
RHEA:44848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-tetradecenoyl-(R)-carnitine
REACT:R-SSC-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)
RHEA:54911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (4E)-hexenoyl-CoA + NADP(+)
REACT:R-CFA-68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Canis familiaris)
REACT:R-XTR-212432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DRIP coactivator complex (Xenopus tropicalis)
REACT:R-CEL-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Caenorhabditis elegans)
REACT:R-HSA-5655241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-SSC-9714481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the ER membrane (Sus scrofa)
RHEA:42484	skos:prefLabel	"protein-N(pi)-phosphohistidine--D-sorbitol phosphotransferase"
RHEA:42484	skos:altLabel	"sorbitol PTS permease"
RHEA:42484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--D-sorbitol phosphotransferase"
RHEA:42484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-sorbitol 6-phosphate(in) + L-histidyl-[protein]
RHEA:42484	skos:altLabel	"glucitol PTS permease"
RHEA:42484	skos:altLabel	"D-sorbitol PTS permease"
GO:0030341	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinase activity
GO:0030341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitinase AC
GO:0030341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin lyase activity
GO:0030341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ChnAC
GO:0030341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin sulfate lyase activity
GO:0030341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin AC lyase activity
GO:0030341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin AC eliminase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	microtubule-associated protein 2 kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+/CaM-dependent kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium/calmodulin-dependent protein kinase type II activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ca2+/calmodulin-dependent protein kinase II activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CaM kinase II activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calmodulin-dependent protein kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multifunctional calcium- and calmodulin-regulated protein kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CaMKKalpha
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ca2+/calmodulin-dependent protein kinase kinase beta activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CAM PKII
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ca2+/calmodulin-dependent protein kinase kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multifunctional calcium/calmodulin regulated protein kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CaMKKbeta
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CaMKIV
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ca2+/calmodulin-dependent protein kinase 1 activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CaM-regulated serine/threonine kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CaMKII
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ca2+/calmodulin-dependent protein kinase IV activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calmodulin-dependent kinase II activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ca2+/calmodulin-dependent protein kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP:caldesmon O-phosphotransferase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calmodulin regulated protein kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CaM kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calmodulin-dependent protein kinase I activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK20
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	calcium/calmodulin-dependent protein kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	caldesmon kinase (phosphorylating) activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium- and calmodulin-dependent protein kinase activity
GO:0004683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CaMKI
RHEA:45027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADPH + O2 <=> 7-dehydrocholesterol + 2 H2O + NADP(+)
RHEA:36634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 1,5-bisphosphate + O2 <=> (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)
RHEA:22699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + androst-4-ene-3,17-dione + O2 <=> A + H2O + testololactone
REACT:R-SSC-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Sus scrofa)
GO:0102628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	costunolide 3beta-hydroxylase activity
REACT:R-SSC-2562594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated OPTN translocates to the nucleus (Sus scrofa)
REACT:R-CFA-430158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds VAV (Canis familiaris)
RHEA:47551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-4-en-24-oate <=> 3-oxochola-4,6-dien-24-oate + H2O
RHEA:32195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O
RHEA:45789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol => 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA
REACT:R-DRE-443910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 dissociates from integrin alphaIIb beta3 (Danio rerio)
EC:2.9.-.-	skos:prefLabel	"Transferring selenium-containing groups"
EC:2.9.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring selenium-containing groups"
REACT:R-GGA-216058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Gallus gallus)
REACT:R-BTA-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)
REACT:R-HSA-5660840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-XTR-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Xenopus tropicalis)
RHEA:24114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + H2O2 => 2 glutathione + O2
REACT:R-HSA-9662818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane (Homo sapiens)
RHEA:36074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-tuliposide A <=> D-glucose + tulipalin A
GO:0102794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinnamaldehyde:oxygen oxidoreductase activity
REACT:R-SSC-158609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers CH3 from AdoMet to 6MP (Sus scrofa)
GO:0047526	skos:prefLabel	"2'-hydroxyisoflavone reductase"
GO:0047526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-vestitone + NADP(+) = 2'-hydroxyformononetin + 2 H(+) + NADPH
GO:0047526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-hydroxyisoflavone reductase"
GO:0047526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoflavone reductase activity
GO:0047526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxyisoflavone reductase activity
GO:0047526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vestitone:NADP+ oxidoreductase activity
GO:0047526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:2'-hydroxyisoflavone oxidoreductase activity
GO:0047526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity
RHEA:28195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH
REACT:R-RNO-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)
RHEA:64192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-lysine = (9Z)-octadecenoate + L-lysine
REACT:R-MMU-9668023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to FVIII (Mus musculus)
RHEA:29827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg(2+)(in) = Mg(2+)(out)
REACT:R-GGA-433550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2 (Gallus gallus)
REACT:R-GGA-749456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)
REACT:R-DDI-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Dictyostelium discoideum)
REACT:R-CFA-193961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Canis familiaris)
RHEA:26165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + echinenone + O2 => 4'-hydroxyechinenone + A + H2O
GO:0004033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldo-keto reductase activity
GO:0004033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldo-keto reductase (NADP) activity
GO:0004033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH-dependent aldo-keto reductase activity
GO:0004033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldo-keto reductase (NADP+) activity
GO:0004033	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alcohol dehydrogenase (NADP+) activity
REACT:R-XTR-2168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds DLL4 (Xenopus tropicalis)
RHEA:52558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-O-phospho-D-erythronate + ADP + H(+) => 3-dehydro-D-erythronate + ATP
REACT:R-HSA-9727869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to HNRNPA1 (Homo sapiens)
REACT:R-DDI-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Dictyostelium discoideum)
RHEA:61877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-MMU-8984023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Mus musculus)
REACT:R-XTR-76416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Benzene is hydroxylated to phenol (Xenopus tropicalis)
REACT:R-MMU-8942575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Mus musculus)
RHEA:65531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + octanoyl-CoA <=> CoA + hexyl octanoate
REACT:R-HSA-5685156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2 (Homo sapiens)
REACT:R-HSA-3785711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Telomere shortening during replicative exhaustion (Homo sapiens)
REACT:R-SSC-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Sus scrofa)
RHEA:18977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate
RHEA:13343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine
REACT:R-GGA-2029451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Gallus gallus)
RHEA:53398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+) => a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein]
REACT:R-CFA-6811423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Canis familiaris)
REACT:R-MMU-264458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of COP1 (Mus musculus)
REACT:R-XTR-203680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:NOSIP translocation from caveolae to intracellular compartments (Xenopus tropicalis)
RHEA:13016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-BTA-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Bos taurus)
REACT:R-MMU-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Mus musculus)
RHEA:36259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(1-hydroxyalkyl)-sn-glycerol = an aldehyde + glycerol
REACT:R-RNO-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)
RHEA:41325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate
REACT:R-CFA-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Canis familiaris)
REACT:R-MMU-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Mus musculus)
RHEA:35420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP
REACT:R-CFA-83803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Canis familiaris)
REACT:R-DRE-4570554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO1 (Danio rerio)
REACT:R-MMU-420580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:PVRL3 trans heterodimer formation (Mus musculus)
RHEA:23989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate
REACT:R-CFA-4719448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO3 (Canis familiaris)
RHEA:20116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 1-phosphate <=> beta-D-glucose 6-phosphate
REACT:R-DRE-8957241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP73 tetramer translocates to the nucleus (Danio rerio)
REACT:R-MMU-163214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from reduced cytochrome c to molecular oxygen (Mus musculus)
RHEA:67760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-BTA-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Bos taurus)
REACT:R-XTR-1472121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of p-KIT on Y900 by Src kinases (Xenopus tropicalis)
RHEA:54776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)
REACT:R-XTR-9615249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBs bind AGRT1 (Xenopus tropicalis)
REACT:R-CFA-171059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Canis familiaris)
REACT:R-CEL-2168046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XII degradation by MMP12 (Caenorhabditis elegans)
RHEA:71392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) => 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)
REACT:R-RNO-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Rattus norvegicus)
REACT:R-HSA-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)
REACT:R-DRE-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Danio rerio)
RHEA:50706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + propanal => 1-propanol + NAD(+)
REACT:R-PFA-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Plasmodium falciparum)
REACT:R-SCE-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Saccharomyces cerevisiae)
REACT:R-HSA-70655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate (Homo sapiens)
REACT:R-HSA-8849042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS3 (Homo sapiens)
RHEA:65820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:55144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH
REACT:R-DME-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Drosophila melanogaster)
RHEA:44960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + H(+) + NADPH = decanoyl-CoA + NADP(+)
RHEA:61875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-MMU-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)
RHEA:63129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-docosanoyl-ethanolamine => docosanoate + ethanolamine
RHEA:56606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)
REACT:R-DDI-209925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIT and MIT combine to form triiodothyronine (Dictyostelium discoideum)
REACT:R-SPO-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Schizosaccharomyces pombe)
REACT:R-XTR-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Xenopus tropicalis)
RHEA:45978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2
RHEA:47752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine = 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine
RHEA:20575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-PFA-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)
REACT:R-MMU-5358340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoproteolytic cleavage of Hh precursors (Mus musculus)
RHEA:44933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate
RHEA:10315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + terephthalate <=> (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)
RHEA:48793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + Lc4Cer => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
REACT:R-DRE-444859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Danio rerio)
REACT:R-MMU-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Mus musculus)
RHEA:29293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate => (25S)-3-oxocholest-4-en-26-oate + ATP + CoA
RHEA:67545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine
REACT:R-CFA-201790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 is dephosphorylated on Thr75 by PP2A (Canis familiaris)
RHEA:15667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose + L-lysyl-[protein]
REACT:R-CFA-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Canis familiaris)
RHEA:38863	skos:prefLabel	"sucrose 6(F)-phosphate phosphorylase"
RHEA:38863	skos:altLabel	"sucrose 6'-phosphate phosphorylase"
RHEA:38863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sucrose 6(F)-phosphate = alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate
RHEA:38863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sucrose 6(F)-phosphate phosphorylase"
REACT:R-GGA-5690827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 (Gallus gallus)
REACT:R-HSA-2730837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-10Y-NTAL (Homo sapiens)
REACT:R-CEL-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Caenorhabditis elegans)
RHEA:34641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + neopentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2
RHEA:42677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + L-histidine + O2 => H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide
REACT:R-DRE-6808487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)
REACT:R-HSA-114354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP:Caspase-7 (Homo sapiens)
REACT:R-DME-350400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PK binds to DSH (Drosophila melanogaster)
REACT:R-HSA-9650710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translation of PPP1R15A (Homo sapiens)
GO:0047137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity
GO:0047137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity
GO:0047137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-hydroxy-2-acetylaminofluorene reductase activity
GO:0047137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-acetamidofluorene:NAD(P)+ oxidoreductase activity
GO:0047137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-2-acetamidofluorene reductase activity
RHEA:64226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine(34) in tRNA + A + H2O => AH2 + O2 + uridine(34) in tRNA
RHEA:44197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylundecanoate + ATP + CoA => 3-methylundecanoyl-CoA + AMP + diphosphate
REACT:R-HSA-9026967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 inhibitors binds VKORC1 dimer (Homo sapiens)
REACT:R-CEL-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
RHEA:65931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Homo sapiens)
REACT:R-CEL-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:56207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)
REACT:R-SSC-6794347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 dimerizes (Sus scrofa)
RHEA:66077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + L-kynurenine => H2O + kynurenate + L-2-aminopentanoate
RHEA:19955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + pyruvate => a 2-oxocarboxylate + L-alanine
GO:0005160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	activin
GO:0005160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor beta receptor binding
GO:0005160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta ligand binding to type II receptor
GO:0005160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta ligand binding to type I receptor
GO:0005160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFbeta receptor binding
GO:0005160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inhibin
GO:0005160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGF-beta receptor binding
GO:0005160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta receptor anchoring activity
GO:0005160	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transforming growth factor beta
GO:0005160	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transforming growth factor beta receptor ligand
REACT:R-BTA-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Bos taurus)
REACT:R-DME-193407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
REACT:R-XTR-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Xenopus tropicalis)
GO:0001223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription coactivator binding
GO:0001223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcription coactivator binding
REACT:R-DME-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Drosophila melanogaster)
RHEA:19859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16-oxosteroid + H(+) + NADPH => a 16alpha-hydroxysteroid + NADP(+)
REACT:R-PFA-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)
GO:0106260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-DNA tethering activity
GO:0106260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded DNA bridging
GO:0106260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dsDNA bridging
RHEA:24514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(pyrazol-1-yl)-L-alanine + H2O => L-serine + pyrazole
REACT:R-DME-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)
RHEA:25647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pulegone + H(+) + NADPH => (2R,5R)-isomenthone + NADP(+)
REACT:R-SSC-175983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfer CH3 from AdoMet to 3,4DHBNZ (Sus scrofa)
RHEA:28227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:37789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine
RHEA:54514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-9,13-epoxylabd-14-ene + diphosphate => peregrinol diphosphate
RHEA:30361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide b + 3 H2O + 2 NADP(+) => chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2
RHEA:25464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + longifolene
RHEA:25464	skos:prefLabel	"longifolene synthase"
RHEA:25464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"longifolene synthase"
GO:1902052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-Delta(7)-dafachronate binding
RHEA:31850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> shionone
GO:0050142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrogenase (flavodoxin) activity
GO:0050142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)
REACT:R-BTA-202307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Change of PKC theta conformation (Bos taurus)
REACT:R-BTA-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Bos taurus)
RHEA:60878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O
RHEA:54506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hexaprene + diphosphate => all-trans-hexaprenyl diphosphate
REACT:R-CFA-4641260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)
REACT:R-MMU-5659781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 forms a heterodimer with BARD1 (Mus musculus)
REACT:R-HSA-396996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs binds G-protein Gq (Homo sapiens)
REACT:R-XTR-204863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang2 (Xenopus tropicalis)
REACT:R-HSA-5675431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates RAF1 (Homo sapiens)
REACT:R-HSA-5602606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)
REACT:R-DRE-5229132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 binds APP (Danio rerio)
RHEA:42924	skos:prefLabel	"16S rRNA (cytidine(1402)-2'-O)-methyltransferase"
RHEA:42924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (cytidine(1402)-2'-O)-methyltransferase"
RHEA:42924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-PFA-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)
REACT:R-DME-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Drosophila melanogaster)
REACT:R-RNO-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Rattus norvegicus)
RHEA:68086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] => GTP + L-histidyl-[RNA ligase]
RHEA:48325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b + GDP-beta-L-fucose => ganglioside Fuc-GD1b + GDP + H(+)
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA:m(5)U54-methyltransferase activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA:m5U54-methyltransferase activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA uracil 5-methyltransferase activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribothymidyl synthase activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer RNA uracil methylase activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	M5U-methyltransferase activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer RNA uracil 5-methyltransferase activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RUMT activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RUMT
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (uracil-5-)-methyltransferase activity
GO:0030697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity
RHEA:42192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:31963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:70619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Homo sapiens)
REACT:R-BTA-9027633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Bos taurus)
REACT:R-DRE-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Danio rerio)
REACT:R-SSC-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Sus scrofa)
REACT:R-HSA-452102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dimerizes (Homo sapiens)
RHEA:68617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + H(+) + NADPH => cortisol + NADP(+)
REACT:R-GGA-353323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in GG-NER (Gallus gallus)
REACT:R-CFA-443910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)
RHEA:72449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate(out) + estrone 3-sulfate(in) => a dicarboxylate(in) + estrone 3-sulfate(out)
RHEA:28680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-8 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-8
RHEA:59994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + phloretate
RHEA:61965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone
REACT:R-XTR-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Xenopus tropicalis)
RHEA:58206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine
RHEA:54826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein]
REACT:R-RNO-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Rattus norvegicus)
RHEA:57141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
REACT:R-BTA-2025890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds NFATC1,2,3 (Bos taurus)
RHEA:42540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(13) in tRNA = pseudouridine(13) in tRNA
RHEA:42540	skos:altLabel	"tRNA Psi(13) synthase"
RHEA:42540	skos:prefLabel	"tRNA pseudouridine(13) synthase"
RHEA:42540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA pseudouridine(13) synthase"
RHEA:33589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
RHEA:26402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-10'-apo-beta-carotenal + O2 => (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone
REACT:R-XTR-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Xenopus tropicalis)
RHEA:21296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + NAD(+) = D-galactono-1,4-lactone + H(+) + NADH
RHEA:21296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-galactose 1-dehydrogenase"
RHEA:21296	skos:prefLabel	"D-galactose 1-dehydrogenase"
RHEA:43871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)
REACT:R-MMU-158399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein binds SERPING1 (Mus musculus)
REACT:R-XTR-749452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gq complex dissociates (Xenopus tropicalis)
RHEA:17818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
REACT:R-DRE-390427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Danio rerio)
REACT:R-SSC-2464809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates the transport of atROL from ROS to RPE (Sus scrofa)
RHEA:62038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O
REACT:R-SSC-446684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Sus scrofa)
REACT:R-BTA-9018868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Bos taurus)
REACT:R-PFA-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Plasmodium falciparum)
REACT:R-CFA-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Canis familiaris)
REACT:R-SCE-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Saccharomyces cerevisiae)
REACT:R-RNO-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Rattus norvegicus)
REACT:R-SSC-2454208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta and gamma subunits by LYN (Sus scrofa)
RHEA:15035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + pyridoxal => O2 + pyridoxine
RHEA:56796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(I)alamin-[corrinoid adenosyltransferase] = adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate
RHEA:66766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + folate(out) + H(+) + phosphate => ATP + folate(in) + H2O
REACT:R-DME-5205663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Drosophila melanogaster)
REACT:R-SSC-4608854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 are recruited to the DVL2:PARD6A complex (Sus scrofa)
RHEA:66430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose(in) + H(+)(in) => D-arabinose(out) + H(+)(out)
REACT:R-GGA-3828025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP14 (Gallus gallus)
RHEA:33018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 <=> [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)
RHEA:37451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA
REACT:R-DRE-2685505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPCN1/2 transport lysosomal Ca2+ to cytosol  (Danio rerio)
RHEA:20773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) => 5-amino-6-(D-ribitylamino)uracil + riboflavin
REACT:R-MMU-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Mus musculus)
REACT:R-HSA-844447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 senses MDP (Homo sapiens)
REACT:R-DME-8933328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYPLA2 hydrolyses PALM-C3,4-GAP43 (Drosophila melanogaster)
REACT:R-CFA-1564164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type V degradation by MMP2,9,10 (Canis familiaris)
GO:0106245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine-phosphatidylethanolamine phosphatidyltransferase activity
RHEA:10510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate
RHEA:36972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-allose
REACT:R-BTA-5693012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF15 binds TNFRSF25 (Bos taurus)
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fibroblast growth factor 1 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FGF 1 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FGF 4 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fibroblast growth factor 4 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fibroblast growth factor 5 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fibroblast growth factor 2 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fibroblast growth factor 6 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FGF 5 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FGF 2 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibroblast growth factor binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FGF 3 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fibroblast growth factor 3 binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGF binding
GO:0017134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FGF 6 binding
REACT:R-HSA-9698000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 mutants:GRB2 bind GAB2 (Homo sapiens)
REACT:R-MMU-2029271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
GO:0030975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin binding
GO:0030975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine binding
GO:0030975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B1 binding
RHEA:29364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => 2'-deoxycytidine + phosphate
REACT:R-RNO-195664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Rattus norvegicus)
RHEA:45803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-demethylaclacinomycin T + AH2 + O2 <=> 10-decarboxymethylaclacinomycin T + A + CO2 + H2O
REACT:R-CEL-8934742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRMT1 (Caenorhabditis elegans)
GO:0015430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate ABC transporter
GO:0015430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled glycerol-3-phosphate transmembrane transporter activity
GO:0015430	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycerol-phosphate porter activity
GO:0015430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type glycerol 3-phosphate transporter
GO:0015430	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP-dependent glycerol-2-phosphate transmembrane transporter activity
GO:0015430	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycerol phosphate-importing ATPase activity
GO:0015430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type glycerol-3-phosphate transporter activity
GO:0015430	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATPase-coupled glycerol-2-phosphate transmembrane transporter activity
GO:0015430	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycerol-2-phosphate-transporting ATPase activity
GO:0015430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol-3-phosphate-transporting ATPase
RHEA:11743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + NADP(+) <=> glutathione disulfide + H(+) + NADPH
RHEA:18898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine
REACT:R-BTA-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Bos taurus)
REACT:R-RNO-927813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
REACT:R-HSA-1482868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Homo sapiens)
REACT:R-MMU-9012349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)
REACT:R-CFA-139908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DLC2 by MAPK8 (Canis familiaris)
REACT:R-HSA-167288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of HIV-1 elongation from arrest (Homo sapiens)
REACT:R-GGA-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Gallus gallus)
REACT:R-RNO-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Rattus norvegicus)
RHEA:63196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10bR,4aS)-noroxomaritidine + H(+) + NADPH = (10bR,4aS)-oxomaritidine + NADP(+)
GO:0047724	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosinase activity
GO:0047724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine nucleosidase activity
GO:0047724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + inosine = D-ribose + hypoxanthine
GO:0047724	skos:altLabel	"inosinase"
GO:0047724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inosine nucleosidase"
GO:0047724	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine ribohydrolase activity
GO:0047724	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine-guanosine nucleosidase activity
GO:0047724	skos:prefLabel	"inosine nucleosidase"
RHEA:65801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O => a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine
REACT:R-CEL-354124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
REACT:R-DRE-2730904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Danio rerio)
RHEA:34535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + L-alanine = 1-deoxy-3-dehydrosphinganine + CO2 + CoA
RHEA:28671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate
REACT:R-GGA-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Gallus gallus)
REACT:R-DDI-9687638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds IP4, IP5 and IP6  (Dictyostelium discoideum)
RHEA:50303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]
RHEA:15994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)
REACT:R-BTA-9749647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES2 hydrolyzes ASA- (Bos taurus)
REACT:R-CFA-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
RHEA:20184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose derivative + UDP-alpha-D-glucose <=> 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP
EC:2.4.1.226	skos:prefLabel	"N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase"
EC:2.4.1.226	skos:altLabel	"chondroitin glucuronyltransferase II"
EC:2.4.1.226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase"
REACT:R-DRE-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)
RHEA:24035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose <=> 6-O-alpha-D-glucopyranosyl-D-fructose
REACT:R-DDI-5674496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate MAP2K1 (Dictyostelium discoideum)
RHEA:12868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methyladenosine + H2O <=> 1-methyladenine + D-ribose
REACT:R-GGA-139895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAK protein (Gallus gallus)
REACT:R-MMU-9027281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Mus musculus)
REACT:R-BTA-6790487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 ubiquitinates SUMOylated XPC (Bos taurus)
RHEA:32524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nigerose + phosphate => beta-D-glucose 1-phosphate + D-glucose
RHEA:32359	skos:altLabel	"IP3/IP4 dual-specificity 6-/3-kinase"
RHEA:32359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)
RHEA:32359	skos:prefLabel	"inositol-polyphosphate multikinase"
RHEA:32359	skos:altLabel	"IP3/IP4 6-/3-kinase"
RHEA:32359	skos:altLabel	"inositol polyphosphate 6-/3-/5-kinase"
RHEA:32359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-polyphosphate multikinase"
RHEA:32359	skos:altLabel	"IpK2"
RHEA:28969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline(out) + Na(+)(out) => L-proline(in) + Na(+)(in)
REACT:R-BTA-5668534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Bos taurus)
REACT:R-GGA-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Gallus gallus)
REACT:R-BTA-5690042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)
REACT:R-MMU-212005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2F1 dehydrogenates 3-methylindole (Mus musculus)
GO:0102208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-polyprenyl-6-hydroxyphenol methylase activity
REACT:R-BTA-168405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD oligomer recruites RIP2 (RICK) (Bos taurus)
GO:0003851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
GO:0003851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity
GO:0003851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity
GO:0003851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity
GO:0003851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cerebroside synthase activity
GO:0003851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity
GO:0003851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-ceramide galactosyltransferase activity
GO:0003851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:ceramide galactosyltransferase activity
GO:0003851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity
RHEA:34124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7-trioxododecanoyl-CoA => CoA + H(+) + olivetolate
RHEA:29440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(in) + H(+)(out) => Fe(2+)(out) + H(+)(in)
REACT:R-GGA-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Gallus gallus)
REACT:R-HSA-6803858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the SFN gene (Homo sapiens)
REACT:R-GGA-5654603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS3 (Gallus gallus)
REACT:R-XTR-8936584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)
REACT:R-CFA-446894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	unspecific monooxygenase activity
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP19
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xenobiotic monooxygenase activity
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aryl-4-monooxygenase activity
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	microsomal monooxygenase activity
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	microsomal P-450
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavoprotein-linked monooxygenase activity
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	microsomal p450 activity
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aryl hydrocarbon hydroxylase activity
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome p450 activity
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0016712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavoprotein monooxygenase activity
REACT:R-DRE-193702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of the ICD migrates to the nucleus (Danio rerio)
REACT:R-HSA-158941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Homo sapiens)
REACT:R-HSA-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Homo sapiens)
REACT:R-GGA-9707516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM dissociates from MetHb (Gallus gallus)
RHEA:20162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose => myo-inositol + raffinose
REACT:R-XTR-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Xenopus tropicalis)
REACT:R-XTR-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Xenopus tropicalis)
RHEA:57852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase
REACT:R-XTR-2465890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR2 binds collagen type I, II, III, V, X fibrils (Xenopus tropicalis)
REACT:R-GGA-6794355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 binds mGluR1a,5 (Gallus gallus)
REACT:R-DRE-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Danio rerio)
RHEA:43780	skos:altLabel	"2-methyl branched chain acyl-CoA dehydrogenase"
RHEA:43780	skos:altLabel	"2-methylacyl-CoA dehydrogenase"
RHEA:43780	skos:altLabel	"branched-chain acyl-CoA dehydrogenase"
RHEA:43780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:43780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"short-chain 2-methylacyl-CoA dehydrogenase"
RHEA:43780	skos:prefLabel	"short-chain 2-methylacyl-CoA dehydrogenase"
RHEA:43780	skos:altLabel	"2-methyl-branched-chain-enoyl-CoA reductase"
RHEA:43780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:46686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2 => 3-oxochol-4-en-24-oyl-CoA + A
REACT:R-BTA-2395965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)
REACT:R-RNO-8870489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA4,(5,6) bind PI3P (Rattus norvegicus)
REACT:R-DME-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-MMU-5632738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDIT4 binds 14-3-3 dimer (Mus musculus)
REACT:R-CFA-419001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Canis familiaris)
RHEA:59388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid ester + H2O = a fatty acid + an aliphatic alcohol + H(+)
GO:0050066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine 2,3-aminomutase activity
GO:0050066	skos:prefLabel	"lysine 2,3-aminomutase"
GO:0050066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine 2,3-aminomutase activity
GO:0050066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine 2,3-aminomutase"
GO:0050066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine = (3S)-3,6-diaminohexanoate
REACT:R-HSA-9008692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds SMAD3 (Homo sapiens)
RHEA:17756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine <=> (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine
REACT:R-RNO-6785821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS5,(SOCS1) bind IL4RA (Rattus norvegicus)
REACT:R-HSA-6809707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTMR2 (Homo sapiens)
REACT:R-HSA-5678313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Homo sapiens)
RHEA:34159	skos:altLabel	"UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase"
RHEA:34159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + UDP-N-acetylbacillosamine = CoA + H(+) + UDP-N,N'-diacetylbacillosamine
RHEA:34159	skos:prefLabel	"UDP-N-acetylbacillosamine N-acetyltransferase"
RHEA:34159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylbacillosamine N-acetyltransferase"
GO:0004357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
GO:0004357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamylcysteine synthetase activity
GO:0004357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamylcysteinyl synthetase activity
GO:0004357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-cysteine ligase activity
GO:0004357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamyl-L-cysteine synthetase activity
RHEA:69551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-phospho-L-serine <=> CO2 + phosphoethanolamine
REACT:R-GGA-8944225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVII (Gallus gallus)
RHEA:65104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene D + L-prolyl-[peptidyl-carrier protein] = aculene B + holo-[peptidyl-carrier protein]
REACT:R-CFA-9014295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GAPs stimulate RAC2 GTPase activity (Canis familiaris)
REACT:R-CFA-5252079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Canis familiaris)
REACT:R-DRE-8876446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ULK1 phosphorylates DENND3 (Danio rerio)
REACT:R-RNO-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Rattus norvegicus)
EC:3.4.23.12	skos:altLabel	"Nepenthes aspartic proteinase"
EC:3.4.23.12	skos:prefLabel	"nepenthesin"
EC:3.4.23.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nepenthesin"
RHEA:28263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose => 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP
REACT:R-BTA-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Bos taurus)
REACT:R-HSA-8849032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS2 (Homo sapiens)
REACT:R-HSA-2399969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 (Homo sapiens)
REACT:R-DME-376200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A10-mediated uptake of small neutral amino acids (Drosophila melanogaster)
REACT:R-CEL-8865107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MICAL1 produces NADP+, H2O2 (Caenorhabditis elegans)
RHEA:17801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine N-acetyltransferase"
RHEA:17801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-phenylalanine = CoA + H(+) + N-acetyl-L-phenylalanine
RHEA:17801	skos:prefLabel	"phenylalanine N-acetyltransferase"
REACT:R-BTA-6804485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates L3MBTL2 with SUMO2 (Bos taurus)
RHEA:63186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 superoxide => NADH + 2 O2
RHEA:29515	skos:prefLabel	"GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase"
RHEA:29515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase"
RHEA:29515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)
RHEA:29515	skos:altLabel	"GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase"
RHEA:29515	skos:altLabel	"mannosyltransferase II"
RHEA:46483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-BTA-5358343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT palmitoylates Hh N-terminal fragment (Bos taurus)
RHEA:33266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
GO:0034523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-formylsalicylate oxidase activity
GO:0043878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
GO:0043878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity
GO:0043878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)
GO:0043878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity
GO:0043878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate dehydrogenase (NAD) activity
REACT:R-DME-174251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Drosophila melanogaster)
RHEA:71987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene C
RHEA:35058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichlorocatechol + O2 <=> (2E,4E)-2,5-dichloromuconate + H(+)
REACT:R-RNO-5668543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3:NIK binds TRAF2:cIAP1/2 (Rattus norvegicus)
RHEA:12361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine => 13-(2-methylcrotonoyloxy)lupanine + CoA
RHEA:63572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin-(1-8) = L-arginine + neurotensin-(1-7)
REACT:R-DRE-2160931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of tight junctions (Danio rerio)
RHEA:15232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-alpha-D-mannose
RHEA:71603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + oxaloacetate(in) = 2-oxoglutarate(in) + oxaloacetate(out)
REACT:R-DRE-192331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Danio rerio)
REACT:R-HSA-9034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 dimers trans-autophosphorylate (Homo sapiens)
RHEA:40246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH
REACT:R-BTA-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Bos taurus)
RHEA:18995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2
RHEA:56633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neryl diphosphate => 1,8-cineole + diphosphate
RHEA:18247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CoA + H(+) => 3'-dephospho-CoA + ATP
RHEA:62644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z)-eicosadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)-eicosadienoate
RHEA:21675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine
REACT:R-GGA-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Gallus gallus)
REACT:R-RNO-444498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin-releasing hormone receptor binds thyrotropin (Rattus norvegicus)
GO:0102883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-beta-chamigrene synthase activity
REACT:R-CFA-190408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2b (Canis familiaris)
RHEA:40939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH = 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)
REACT:R-DME-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Drosophila melanogaster)
RHEA:11121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate + 3 H(+) + hydrogencarbonate => 2 CO2 + NH4(+)
REACT:R-SSC-183130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Sus scrofa)
RHEA:44543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
RHEA:52589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH
REACT:R-BTA-936952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Bos taurus)
RHEA:50155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O
REACT:R-CFA-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Canis familiaris)
RHEA:46399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:55382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo bile acid CoA + H(+) + NADH => a 3alpha-hydroxy bile acid CoA + NAD(+)
RHEA:46714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine
RHEA:64860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine = (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine
RHEA:28695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(in) = hydrogencarbonate(out)
RHEA:31529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O => N(omega)-hydroxy-L-arginine
REACT:R-DME-6799246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates TP53 (Drosophila melanogaster)
REACT:R-CEL-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Caenorhabditis elegans)
RHEA:42760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H2O + NAD(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADH
RHEA:21925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + NAD(+) => 2,3-dioxo-L-gulonate + H(+) + NADH
RHEA:36483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA
RHEA:42801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) => all-trans-4,4'-diaponeurosporene + 3 FADH2
REACT:R-DME-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Drosophila melanogaster)
REACT:R-GGA-9609743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Gallus gallus)
RHEA:39798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxycholesterol(in) + ATP + H2O <=> 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate
REACT:R-CEL-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Caenorhabditis elegans)
RHEA:15231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GTP + H(+)
REACT:R-HSA-8956099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Homo sapiens)
REACT:R-HSA-8950737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL23R binds JAK2 (Homo sapiens)
RHEA:14448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:55241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)
REACT:R-MMU-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Mus musculus)
REACT:R-HSA-8869542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter (Homo sapiens)
RHEA:31169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanoyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanoyl-CoA + NAD(+)
RHEA:42464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2',3-triol + O2 = 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)
REACT:R-DDI-2105001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from DS (Dictyostelium discoideum)
REACT:R-RNO-2022399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Rattus norvegicus)
RHEA:23290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + NADH => acetaldehyde + CoA + NAD(+)
RHEA:38589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	devancoaminyl-vancomycin + UDP => UDP-alpha-D-glucose + vancomycin aglycone
RHEA:32852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-HSA-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Homo sapiens)
REACT:R-HSA-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
RHEA:66095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-kynurenine <=> H2O + kynurenate + L-phenylalanine
GO:0047806	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytochrome hydrogenase activity
GO:0047806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c3 reductase activity
GO:0047806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H(2):ferricytochrome c3 oxidoreductase activity
GO:0047806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:ferricytochrome-c3 oxidoreductase activity
GO:0047806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H2:ferricytochrome c3 oxidoreductase activity
GO:0047806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome-c3 hydrogenase activity
RHEA:19051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-phosphooxy-L-lysine + GDP + H(+) => (5R)-5-hydroxy-L-lysine + GTP
RHEA:62768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
RHEA:43816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:28040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + CDP => [thioredoxin]-disulfide + dCDP + H2O
REACT:R-RNO-8955289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
RHEA:47444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(7Z-hexadecenoyl)-CoA + CoA = (5Z)-tetradecenoyl-CoA + acetyl-CoA
REACT:R-CEL-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Caenorhabditis elegans)
GO:0090439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetraketide alpha-pyrone synthase activity
REACT:R-XTR-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Xenopus tropicalis)
RHEA:41426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + grixazone A + H(+) + 3 H2O => 2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2
REACT:R-CFA-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Canis familiaris)
REACT:R-DRE-390281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Danio rerio)
REACT:R-BTA-983218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B:RAD51C binds single-stranded DNA (Bos taurus)
RHEA:39517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH
REACT:R-MMU-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Mus musculus)
RHEA:47773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Xenopus tropicalis)
RHEA:43735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O <=> 1,3-diacyl-sn-glycerol + a fatty acid + H(+)
RHEA:46147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9610270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3A (GRIN3A) (Homo sapiens)
RHEA:24168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RHEA:53582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]
EC:3.2.1.94	skos:altLabel	"isomalto-dextranase"
EC:3.2.1.94	skos:prefLabel	"glucan 1,6-alpha-isomaltosidase"
EC:3.2.1.94	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan 1,6-alpha-isomaltosidase"
EC:3.2.1.94	skos:altLabel	"exo-isomaltohydrolase"
REACT:R-DRE-6784204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind OSMR (Danio rerio)
REACT:R-SSC-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Sus scrofa)
RHEA:36629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine => 2-hydroxytetracosanoyl-CoA + sphinganine
REACT:R-SSC-9677585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Sus scrofa)
RHEA:13910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + urate D-ribonucleoside => alpha-D-ribose 1-phosphate + urate
RHEA:38972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O2
RHEA:44454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine
RHEA:14297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose
RHEA:14297	skos:altLabel	"galcerase"
RHEA:14297	skos:prefLabel	"galactosylceramidase"
RHEA:14297	skos:altLabel	"galactocerebrosidase"
RHEA:14297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactosylceramidase"
RHEA:14297	skos:altLabel	"galactocerebroside beta-galactosidase"
RHEA:14297	skos:altLabel	"galactosylceramide beta-galactosidase"
RHEA:27369	skos:prefLabel	"acetoin dehydrogenase system"
RHEA:27369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetoin dehydrogenase system"
RHEA:27369	skos:altLabel	"acetoin dehydrogenase"
RHEA:27369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin + CoA + NAD(+) = acetaldehyde + acetyl-CoA + H(+) + NADH
REACT:R-DRE-9724685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds omalizumab (Danio rerio)
RHEA:19724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CEL-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Caenorhabditis elegans)
GO:0015481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose transporting porin activity
GO:0015481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltoporin
RHEA:19743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + formate + H(+) => formyl-CoA + H2O
REACT:R-DME-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)
RHEA:27707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanine + D-serine => ADP + D-alanyl-D-serine + H(+) + phosphate
RHEA:33025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + D-ribulose 5-phosphate + NADH => 6-phospho-D-gluconate + NAD(+)
RHEA:62377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-didehydro-3-deoxy-L-rhamnonate + H2O => (S)-lactate + H(+) + pyruvate
REACT:R-XTR-1483096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA is dephosphorylated to ETA by PHOSPHO1 (Xenopus tropicalis)
RHEA:14076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-glutamate + H(+) <=> 4-amino-3-hydroxybutanoate + CO2
REACT:R-HSA-5661517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC comlex binds OTULIN (Homo sapiens)
RHEA:67319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine <=> (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine
REACT:R-GGA-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Gallus gallus)
REACT:R-HSA-177944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)
REACT:R-CFA-429613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-DME-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Drosophila melanogaster)
REACT:R-HSA-1971491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Homo sapiens)
REACT:R-HSA-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
RHEA:45907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + epivancomycin + H(+)
RHEA:67040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) = asnovolin H
RHEA:64872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 1-phosphate = dihydroxyacetone phosphate + glycolaldehyde
RHEA:60284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-HSA-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Homo sapiens)
REACT:R-DRE-8948230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P3HB binds 4-Hyp-collagen propeptides (Danio rerio)
REACT:R-RNO-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Rattus norvegicus)
RHEA:72812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)
RHEA:56668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
RHEA:56668	skos:prefLabel	"7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase"
RHEA:56668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase"
RHEA:69033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dihydroxy-L-aspartate => (2S)-2-nitrosobutanedioate + H2O
GO:0044583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellotriose binding
RHEA:43158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine => guanosine(9) in tRNA + S-adenosyl-L-methionine
REACT:R-DRE-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Danio rerio)
REACT:R-DRE-8987150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Danio rerio)
RHEA:31389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-amyrin => (S)-2,3-epoxysqualene
REACT:R-RNO-4615873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates SUZ12 with SUMO1 (Rattus norvegicus)
GO:0102248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol transacylase activity
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PCB 4-monooxygenase activity
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentachlorophenol 4-monooxygenase activity
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pentachlorophenol dechlorinase activity
GO:0018677	skos:altLabel	"pentachlorophenol dechlorinase"
GO:0018677	skos:altLabel	"PCP hydroxylase"
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentachlorophenol hydroxylase activity
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentachlorophenol monooxygenase activity
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + pentachlorophenol = 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)
GO:0018677	skos:altLabel	"pentachlorophenol hydroxylase"
GO:0018677	skos:altLabel	"PCB 4-monooxygenase"
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pentachlorophenol dehalogenase activity
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pentachlorophenol monooxygenase"
GO:0018677	skos:altLabel	"pentachlorophenol 4-monooxygenase"
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PcpB
GO:0018677	skos:altLabel	"pentachlorophenol dehalogenase"
GO:0018677	skos:altLabel	"PCB4MO"
GO:0018677	skos:prefLabel	"pentachlorophenol monooxygenase"
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5,6-tetrachlorophenol + NADPH + O2 = 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PCB4MO activity
GO:0018677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PCP hydroxylase activity
REACT:R-RNO-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Rattus norvegicus)
RHEA:30771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + H2O = D-ribose + guanine
EC:1.4.1.25	skos:prefLabel	"L-arginine dehydrogenase"
EC:1.4.1.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arginine dehydrogenase"
EC:1.4.1.25	skos:altLabel	"anabolic L-arginine dehydrogenase"
REACT:R-DME-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Drosophila melanogaster)
RHEA:32081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-ol + diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate + H2O
RHEA:64163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide <=> ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]
REACT:R-CFA-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Canis familiaris)
RHEA:59722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaonate + H(+) => D-maltohexaono-1,5-lactone + H2O
RHEA:24518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(2')-acetylgentamicin C1a => acetyl-CoA + gentamicin C1a
RHEA:32893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene oxide + H2O + NAD(+) => (1S,5S)-alpha-pinene + H(+) + NADH + O2
REACT:R-DDI-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Dictyostelium discoideum)
REACT:R-HSA-2466764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRPE condenses with atRAL to form A2PE (Homo sapiens)
RHEA:45394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-MMU-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Mus musculus)
RHEA:58892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 = adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9
RHEA:58892	skos:prefLabel	"omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase"
RHEA:58892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase"
RHEA:71267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-pipecolate(out) + 2 Na(+)(out) = chloride(in) + L-pipecolate(in) + 2 Na(+)(in)
RHEA:30328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:71265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-proline(in) + 2 Na(+)(in) => chloride(out) + L-proline(out) + 2 Na(+)(out)
RHEA:12348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate
RHEA:12348	skos:altLabel	"muconolactone isomerase"
RHEA:12348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"muconolactone Delta-isomerase"
RHEA:12348	skos:prefLabel	"muconolactone Delta-isomerase"
GO:0018477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzaldehyde:NADP+ oxidoreductase
GO:0018477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde dehydrogenase (NADP+) activity
GO:0018477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-linked benzaldehyde dehydrogenase
REACT:R-RNO-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Rattus norvegicus)
RHEA:41481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + episterol => an episterol ester + CoA
RHEA:55029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine => an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine
RHEA:23493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucosamine => UDP-alpha-D-galactosamine
RHEA:46430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => 4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-HSA-9024983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Homo sapiens)
REACT:R-MMU-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Mus musculus)
GO:0043135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity
GO:0043135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRPP pyrophosphatase activity
REACT:R-SSC-9714361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC activates endoplasmic reticulum effectors (Sus scrofa)
RHEA:63037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanamide => NH4(+) + octadecanoate
REACT:R-PFA-110250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenoadenine by MPG glycosylase (Plasmodium falciparum)
REACT:R-CFA-202233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Lck by Csk (Canis familiaris)
REACT:R-CFA-750993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (q) reassociates with G beta:gamma (Canis familiaris)
GO:0047617	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acyl-CoA thioesterase II activity
GO:0047617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)
GO:0047617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA thiolesterase activity
GO:0047617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thioesterase B
GO:0047617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA thioesterase activity
GO:0047617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thioesterase II
GO:0047617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA hydrolase activity
GO:0047617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl coenzyme A hydrolase activity
GO:0047617	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acyl-CoA thioesterase I activity
GO:0047617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl coenzyme A thioesterase activity
REACT:R-GGA-2064417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-1 (TJP1) (Gallus gallus)
REACT:R-DME-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)
REACT:R-XTR-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Xenopus tropicalis)
RHEA:48708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
RHEA:56583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-thioguanine + S-adenosyl-L-methionine <=> 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine
RHEA:54462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:21755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin <=> all-trans-capsorubin
RHEA:12138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)
REACT:R-DRE-2022381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)
RHEA:25040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-tRNA(Sec) <=> ADP + O-phospho-L-seryl-tRNA(Sec)
EC:1.14.19.37	skos:altLabel	"acyl-CoA 5-desaturase (non-methylene-interrupted)"
EC:1.14.19.37	skos:prefLabel	"acyl-CoA 5-desaturase"
EC:1.14.19.37	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA 5-desaturase"
RHEA:30796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + CoA + NAD(+) => CO2 + glutaryl-CoA + NADH
RHEA:53861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) => dehydrocholate + H(+) + NADPH
REACT:R-XTR-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Xenopus tropicalis)
REACT:R-GGA-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Gallus gallus)
RHEA:32724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6799462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)
REACT:R-MMU-8864029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Mus musculus)
RHEA:50546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin B2 => prostaglandin C2
REACT:R-PFA-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Plasmodium falciparum)
REACT:R-HSA-6785478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processed tRNA binds XPOT and RAN:GTP (Homo sapiens)
RHEA:13860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + H2O <=> a dolichyl phosphate + D-glucose + H(+)
RHEA:21247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine
RHEA:64028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine
RHEA:30085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Cu(2+) + 2 H2O => 4 Cu(+) + 4 H(+) + O2
REACT:R-SPO-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Schizosaccharomyces pombe)
REACT:R-DME-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Drosophila melanogaster)
REACT:R-MMU-6788912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)
RHEA:46606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[HPr protein]-L-serine + diphosphate => [HPr protein]-O-phospho-L-serine + H(+) + phosphate
RHEA:21014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine
REACT:R-SSC-5683735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 is recruited to DNA DSBs (Sus scrofa)
REACT:R-DRE-2534378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hv1 Mediated H+ Permeability (Danio rerio)
RHEA:28379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-fructosyl)-L-lysine => ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine
EC:3.1.12.1	skos:altLabel	"5' to 3' single stranded DNA exonuclease"
EC:3.1.12.1	skos:prefLabel	"5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming)"
EC:3.1.12.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming)"
RHEA:12352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulono-1,4-lactone + O2 = H2O2 + L-xylo-hex-3-ulonolactone
REACT:R-XTR-5654608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS bind to PPTN11 (Xenopus tropicalis)
REACT:R-MMU-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Mus musculus)
RHEA:47195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] <=> Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M
RHEA:20787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(ADP-D-ribosyl)-L-arginine <=> ADP-D-ribose + L-arginine
REACT:R-HSA-187213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GAG polyprotein (Homo sapiens)
RHEA:35613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + menadione + 2 superoxide => menadiol + 2 O2
REACT:R-GGA-9033499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Gallus gallus)
RHEA:23790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[citrate lyase ACP] + AMP + diphosphate => acetate + ATP + holo-[citrate lyase ACP]
REACT:R-BTA-5690870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Bos taurus)
RHEA:57939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopyridoxal + NAD(+) <=> 5-pyridoxate + 2 H(+) + NADH
REACT:R-BTA-6805573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I/type II heterodimers form tetramers (Bos taurus)
RHEA:34060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agroclavine + NADP(+) => didehydroagroclavine + H(+) + NADPH
RHEA:43916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-6791235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds AURKA (Danio rerio)
REACT:R-DRE-177926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of PAG by SHP2 (Danio rerio)
REACT:R-CFA-209921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoiodinated tyrosine can be deiodinated (Canis familiaris)
RHEA:62816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 monapinone E + O2 = 2 dinapinone E + 2 H2O
REACT:R-CEL-163733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of FAS monomer gene by ChREBP:MLX (Caenorhabditis elegans)
REACT:R-HSA-8935972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TJP1 (ZO-1) gene expression is stimulated by RUNX1 (Homo sapiens)
REACT:R-DDI-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Dictyostelium discoideum)
RHEA:25312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + O2 => glyoxylate + H2O2
REACT:R-GGA-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Gallus gallus)
RHEA:21894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinono-1,4-lactone + H(+) + NADPH => D-arabinose + NADP(+)
RHEA:53982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O
RHEA:47250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate => 2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone
RHEA:23347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine D-ribonucleoside + H2O <=> a purine nucleobase + D-ribose
REACT:R-GGA-5082384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70:DNAJB1 binds HSF1 (Gallus gallus)
RHEA:42800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) = all-trans-4,4'-diaponeurosporene + 3 FADH2
RHEA:28418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + gamma-butyrobetainyl-CoA = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate
RHEA:36540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinganine => CoA + H(+) + N-hexadecanoylsphinganine
REACT:R-RNO-2454192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Allergen dependent IgE bound FCERI aggregation (Rattus norvegicus)
RHEA:48224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose
RHEA:34787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH
REACT:R-HSA-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Homo sapiens)
RHEA:25765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2-oxobutanoate + H(+) + NADH => (2R,3S)-3-methylmalate + NAD(+)
RHEA:40030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate + H2O <=> (13S)-vitexifolin A + diphosphate
RHEA:43474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2
REACT:R-HSA-400023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq alpha activates Phospholipase C beta (Homo sapiens)
GO:0047461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)
GO:0047461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-cadinene synthase activity
GO:0047461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-delta-cadinene synthase activity
GO:0106425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-dopa + O2 = 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)
GO:0106425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPAA synthase
GO:0106425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetaldehyde synthase activity
GO:0106425	skos:prefLabel	"3,4-dihydroxyphenylacetaldehyde synthase"
GO:0106425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,4-dihydroxyphenylacetaldehyde synthase"
REACT:R-BTA-9707659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes:LY96 activates TLR4 (Bos taurus)
REACT:R-RNO-174132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Cyclin B:Cdc2 (Rattus norvegicus)
RHEA:51759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6-diprenylphloroglucinol + diphosphate
RHEA:39717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2
RHEA:36345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+) => 2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2
REACT:R-CFA-5591052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROCR binds Protein C (Canis familiaris)
REACT:R-RNO-380076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 1 (NK1) binds to substance P (Rattus norvegicus)
REACT:R-HSA-451152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP kinase p38 phosphorylates KSRP (Homo sapiens)
RHEA:53118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11-oxosteroid + H(+) + NADH => an 11beta-hydroxysteroid + NAD(+)
REACT:R-DME-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Drosophila melanogaster)
REACT:R-HSA-9036727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAA hydrolyzes lysosomal glycogen (Homo sapiens)
RHEA:68354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',2'-cGAMP + diphosphate => pppA(2'-5')pG
REACT:R-HSA-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Homo sapiens)
REACT:R-DRE-190258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c binds to FGF (Danio rerio)
RHEA:16569	skos:altLabel	"lysine,2-oxoglutarate 5-dioxygenase"
RHEA:16569	skos:prefLabel	"procollagen-lysine 5-dioxygenase"
RHEA:16569	skos:altLabel	"lysine hydroxylase"
RHEA:16569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate
RHEA:16569	skos:altLabel	"procollagen-lysine,2-oxoglutarate 5-dioxygenase"
RHEA:16569	skos:altLabel	"lysyl hydroxylase"
RHEA:16569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"procollagen-lysine 5-dioxygenase"
REACT:R-HSA-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Homo sapiens)
RHEA:27452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate
RHEA:46495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)
REACT:R-RNO-158340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Rattus norvegicus)
RHEA:31515	skos:altLabel	"beta-apo-4'-carotenal dehydrogenase"
RHEA:31515	skos:prefLabel	"beta-apo-4'-carotenal oxygenase"
RHEA:31515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-apo-beta-carotenal + H2O + NAD(+) = 2 H(+) + NADH + neurosporaxanthin
RHEA:31515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-apo-4'-carotenal oxygenase"
REACT:R-MMU-9693478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A agonists (Mus musculus)
REACT:R-DDI-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Dictyostelium discoideum)
REACT:R-DRE-8871194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 and GAPVD1 bind AP-2 (Danio rerio)
REACT:R-SSC-9796368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 binds STUB1 (Sus scrofa)
GO:0018684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diketocamphane 1,2-monooxygenase
GO:0018684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	camphor 1,2-monooxygenase activity
GO:0018684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)
GO:0018684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-diketocamphane lactonizing enzyme activity
GO:0018684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	camphor ketolactonase I activity
RHEA:22202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate
REACT:R-HSA-9646679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded proteins bind vimentin to form aggresome (Homo sapiens)
REACT:R-HSA-9700186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of point mutants of ALK (Homo sapiens)
RHEA:13870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH
REACT:R-SSC-2250301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyrrole cross-links (Sus scrofa)
REACT:R-XTR-209087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBA is phosphorylated by Phospho IKKB kinase (Xenopus tropicalis)
REACT:R-RNO-8987202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)
RHEA:56777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:15829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16alpha-hydroxysteroid = a 16beta-hydroxysteroid
RHEA:15829	skos:prefLabel	"16-hydroxysteroid epimerase"
RHEA:15829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16-hydroxysteroid epimerase"
RHEA:35986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-9701003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 heterodimer (Canis familiaris)
REACT:R-MMU-9038052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GREB1 binds ESR1:ESTG and co-activators (Mus musculus)
REACT:R-MMU-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Mus musculus)
REACT:R-BTA-5696119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)
RHEA:36538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + sphinganine <=> CoA + H(+) + N-docosanoylsphinganine
RHEA:21876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH
RHEA:21876	skos:prefLabel	"(S)-usnate reductase"
RHEA:21876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-usnate reductase"
REACT:R-DME-3108203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO2,3 (Drosophila melanogaster)
REACT:R-SSC-2396606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)
RHEA:72551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + urate(in) = glutarate(in) + urate(out)
REACT:R-CEL-390281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Caenorhabditis elegans)
RHEA:22363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate <=> 5-oxo-D-proline + H2O
REACT:R-DME-5205652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 recruits Parkin to the outer mitochondrial membrane. (Drosophila melanogaster)
REACT:R-MMU-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Mus musculus)
GO:0080109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetonitrile nitrile hydratase activity
REACT:R-RNO-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Rattus norvegicus)
REACT:R-HSA-9022872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds MOBP gene promoter (Homo sapiens)
RHEA:70968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) => 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)
REACT:R-DRE-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Danio rerio)
RHEA:41948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH
RHEA:41948	skos:prefLabel	"[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase"
RHEA:41948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase"
REACT:R-MMU-5610722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI3 (Mus musculus)
REACT:R-DME-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Drosophila melanogaster)
REACT:R-XTR-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Xenopus tropicalis)
REACT:R-SSC-8950724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Sus scrofa)
REACT:R-CEL-264615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Caenorhabditis elegans)
REACT:R-GGA-4084989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Gallus gallus)
RHEA:51540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-corytuberine synthase"
RHEA:51540	skos:prefLabel	"(S)-corytuberine synthase"
RHEA:51540	skos:altLabel	"CYP80G2"
RHEA:51540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-6806831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5Rs reduce MetHb to HbA (Canis familiaris)
RHEA:36895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O
REACT:R-RNO-5625717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PKN1 binds androgen receptor (AR) (Rattus norvegicus)
REACT:R-BTA-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Bos taurus)
REACT:R-RNO-5654634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates SHC1 (Rattus norvegicus)
RHEA:28294	skos:prefLabel	"(-)-beta-caryophyllene synthase"
RHEA:28294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-beta-caryophyllene synthase"
RHEA:28294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-(E)-beta-caryophyllene + diphosphate
REACT:R-RNO-9610154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated MAP2Ks and MAPKs (Rattus norvegicus)
RHEA:26066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B
RHEA:59876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoate + ATP + L-cysteine = (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)
EC:6.3.2.47	skos:altLabel	"dapdiamide A synthase"
EC:6.3.2.47	skos:prefLabel	"dapdiamide synthase"
EC:6.3.2.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dapdiamide synthase"
REACT:R-BTA-1650808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Bos taurus)
RHEA:48613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]
EC:1.3.99.-	skos:prefLabel	"With other acceptors"
EC:1.3.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
RHEA:67573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-muricholate => adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)
REACT:R-RNO-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Rattus norvegicus)
RHEA:48682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH => a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+)
REACT:R-RNO-2028555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Rattus norvegicus)
RHEA:41547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine
RHEA:61998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein] => L-lysyl-[protein] + lactoyl-CoA
REACT:R-MMU-5672843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1S1 (PRAS40) binds mTORC1 (Mus musculus)
RHEA:39866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-HSA-349637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spherical HDL and SR-BI receptor form a complex at the cell surface (Homo sapiens)
REACT:R-SSC-8950340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Sus scrofa)
REACT:R-MMU-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Mus musculus)
GO:0044023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serine kinase activity (H4-S1 specific)
GO:0044023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4S1 kinase activity
GO:0044023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-serine kinase activity (H4-S1 specific)
GO:0044023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H4-S1 specific)
REACT:R-MMU-202325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Gads to LAT (Mus musculus)
RHEA:38804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine
REACT:R-DRE-389487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 2 receptor can bind orexin-B neuropeptide (Danio rerio)
REACT:R-XTR-163825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)
RHEA:15054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide
REACT:R-GGA-8950778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dimerizes (Gallus gallus)
REACT:R-SSC-8985201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL (Sus scrofa)
EC:4.4.-.-	skos:prefLabel	"Carbon-sulfur lyases"
EC:4.4.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carbon-sulfur lyases"
RHEA:33876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z-octadecenoate) + H2O => (9Z)-octadecenoate + cholesterol + H(+)
REACT:R-CFA-5693566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 associates with H4K20Me2 at DNA DSBs (Canis familiaris)
REACT:R-DME-445084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by SRC (Drosophila melanogaster)
RHEA:41332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate
REACT:R-DDI-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Dictyostelium discoideum)
RHEA:19532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovitexin + UDP-alpha-D-glucose <=> H(+) + isovitexin 2''-O-beta-D-glucoside + UDP
GO:0033824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alternansucrase activity
GO:0033824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity
GO:0033824	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity
GO:0033824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity
RHEA:31879	skos:prefLabel	"beta-seco-amyrin synthase"
RHEA:31879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-seco-amyrin synthase"
RHEA:31879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = beta-seco-amyrin
RHEA:43960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:21386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + NH4(+) => L-phenylalanine
REACT:R-SSC-2176475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Sus scrofa)
RHEA:54710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
RHEA:69705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactose + N-hexadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O
REACT:R-MMU-110360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to the AP site (Mus musculus)
RHEA:64415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)
RHEA:65029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-pinoresinol + H2O + 2 oxidized [azurin] => (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]
GO:0030295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase activator activity
REACT:R-DRE-1497869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - Sepiapterin is reduced to BH2 (Danio rerio)
REACT:R-MMU-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Mus musculus)
REACT:R-HSA-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Homo sapiens)
REACT:R-HSA-195418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-2 associates with VEGFR1 forming complexes on  cell surface (Homo sapiens)
REACT:R-HSA-6809663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hair keratin fibres (Homo sapiens)
REACT:R-MMU-1433374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processing of SCF isoform 1 (Mus musculus)
REACT:R-RNO-443783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NUMB with L1 (Rattus norvegicus)
RHEA:25811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermidine <=> 3-aminopropanal + H2O2 + putrescine
REACT:R-SSC-9690493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors on endosomes (Sus scrofa)
GO:0047866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylglycine oxidase activity
GO:0047866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethylglycine:oxygen oxidoreductase (demethylating)
REACT:R-MMU-141139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of TRAIL:TRAIL receptor complex (Mus musculus)
RHEA:25286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:29552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucose => alpha-D-galactose 1-phosphate + 2 H(+) + UMP
REACT:R-DME-192335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Drosophila melanogaster)
REACT:R-SSC-352136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Sus scrofa)
RHEA:42821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 => H2O + 2 NADP(+) + tetracenomycin C
RHEA:46964	skos:prefLabel	"lactate dehydrogenase (NAD(+),ferredoxin)"
RHEA:46964	skos:altLabel	"electron bifurcating LDH/Etf complex"
RHEA:46964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate
RHEA:46964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactate dehydrogenase (NAD(+),ferredoxin)"
RHEA:57823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + ADP <=> [phosphate](n+1) + AMP
RHEA:19639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + L-arginine + NADPH => D-nopaline + H2O + NADP(+)
REACT:R-CEL-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Caenorhabditis elegans)
REACT:R-BTA-196417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of desmosterol to cholesterol (Bos taurus)
RHEA:47747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylphylloquinone + H(+) + NADPH <=> demethylphylloquinol + NADP(+)
EC:1.18.2.-	skos:prefLabel	"With dinitrogen as acceptor"
EC:1.18.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With dinitrogen as acceptor"
REACT:R-SSC-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Sus scrofa)
RHEA:72351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + glycocholate(out) = glutarate(out) + glycocholate(in)
RHEA:59194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + icosanoyl-AMP => ATP + eicosanoate + H(+)
RHEA:50064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurochenodeoxycholate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate(out)
REACT:R-CEL-1169402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of E2 conjugating enzymes (Caenorhabditis elegans)
REACT:R-CFA-5218819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
REACT:R-SCE-453339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)
REACT:R-BTA-9733969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts dissociate from FABP6 (Bos taurus)
RHEA:50849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
REACT:R-CFA-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Canis familiaris)
EC:1.5.1.41	skos:altLabel	"NAD(P)H-dependent FMN reductase"
EC:1.5.1.41	skos:prefLabel	"riboflavin reductase [NAD(P)H]"
EC:1.5.1.41	skos:altLabel	"flavine mononucleotide reductase"
EC:1.5.1.41	skos:altLabel	"riboflavin mononucleotide reductase"
EC:1.5.1.41	skos:altLabel	"NAD(P)H2 dehydrogenase (FMN)"
EC:1.5.1.41	skos:altLabel	"riboflavine mononucleotide reductase"
EC:1.5.1.41	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"riboflavin reductase [NAD(P)H]"
EC:1.5.1.41	skos:altLabel	"flavin mononucleotide reductase"
RHEA:54890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + OPC8-CoA => (1S,2S)-OPC-8 + ATP + CoA
RHEA:45815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain (3R)-3-hydroxyacyl-CoA <=> a very-long-chain (2E)-enoyl-CoA + H2O
REACT:R-XTR-5689972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 deubiquitinates MDM2,MDM4 (Xenopus tropicalis)
GO:0047408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysoplasmalogenase"
GO:0047408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysoplasmalogenase activity
GO:0047408	skos:prefLabel	"lysoplasmalogenase"
GO:0047408	skos:altLabel	"alkenylglycerophosphoethanolamine hydrolase"
GO:0047408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity
GO:0047408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkenylglycerophosphocholine hydrolase activity
GO:0047408	skos:altLabel	"alkenylglycerophosphocholine hydrolase"
REACT:R-GGA-3244643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds cyclic GMP-AMP (Gallus gallus)
REACT:R-DRE-199863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate NR4A1 (NUR77) (Danio rerio)
REACT:R-DME-350359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane (Drosophila melanogaster)
REACT:R-DDI-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Dictyostelium discoideum)
REACT:R-SSC-176585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Sus scrofa)
RHEA:45926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA => 9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA
RHEA:11815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methanethiol + O2 <=> formaldehyde + H(+) + H2O2 + hydrogen sulfide
REACT:R-RNO-9727607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ binds sacubitrilat (Rattus norvegicus)
GO:0018773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylpyruvate hydrolase activity
GO:0018773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylpyruvate + H2O = acetate + H(+) + pyruvate
GO:0018773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4-dioxopentanoate acetylhydrolase activity
GO:0018773	skos:prefLabel	"acetylpyruvate hydrolase"
GO:0018773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylpyruvate hydrolase"
RHEA:10729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-6-deoxy-alpha-D-talose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH
GO:0004164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphthine methyltransferase activity
GO:0004164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity
GO:0004164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthine synthase activity
GO:0004164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity
REACT:R-SCE-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Saccharomyces cerevisiae)
REACT:R-HSA-936941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Homo sapiens)
RHEA:25396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
REACT:R-CEL-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Caenorhabditis elegans)
RHEA:59071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethyldeoxyspectinabilin + S-adenosyl-L-methionine <=> deoxyspectinabilin + S-adenosyl-L-homocysteine
REACT:R-HSA-5682598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates HERC2 (Homo sapiens)
REACT:R-DRE-2187388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Danio rerio)
RHEA:50448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + prostaglandin G3 = A + H2O + prostaglandin H3
RHEA:55694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+) => an inositol-1-phosphoceramide + H2O
GO:0043394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteoglycan binding
RHEA:15818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pyridoxamine 5'-phosphate => H2O2 + NH4(+) + pyridoxal 5'-phosphate
REACT:R-MMU-3697882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN (Mus musculus)
RHEA:28512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 6-phosphate + hydroquinone => arbutin 6-phosphate + H2O
GO:0010472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-L-galactose:glucose-1-phosphate guanylyltransferase activity
GO:0010472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-galactose:glucose-1-phosphate guanylyltransferase activity
GO:0010472	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GDP-L-galactose phosphorylase activity
RHEA:38765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
REACT:R-MMU-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Mus musculus)
REACT:R-SSC-1433415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 (Sus scrofa)
REACT:R-CFA-174171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A with the APC/C (Canis familiaris)
REACT:R-MMU-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Mus musculus)
REACT:R-HSA-9664976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 (Homo sapiens)
RHEA:30273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O => 2 (3,4-dimethoxyphenyl)methanol + H2O2
REACT:R-SSC-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Sus scrofa)
RHEA:27764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + diphosphate + H(+) => CTP + H2O
REACT:R-SCE-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Saccharomyces cerevisiae)
REACT:R-XTR-2046265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the keratan chain (Xenopus tropicalis)
REACT:R-HSA-400071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Homo sapiens)
REACT:R-HSA-5649742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC33A1 does not transport Ac-CoA from cytosol to Golgi lumen (Homo sapiens)
REACT:R-SPO-83790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Schizosaccharomyces pombe)
REACT:R-HSA-4647594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAHF formation (Homo sapiens)
RHEA:26226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-al + H2O + NAD(+) => abieta-7,13-dien-18-oate + 2 H(+) + NADH
REACT:R-BTA-74736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)
REACT:R-GGA-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Gallus gallus)
REACT:R-RNO-2029453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of VAV (Rattus norvegicus)
RHEA:16172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + NH4(+) <=> ADP + H(+) + L-glutamine + phosphate
REACT:R-DRE-5655193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIAA0101 double monoubiquitination (Danio rerio)
REACT:R-CEL-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Caenorhabditis elegans)
REACT:R-BTA-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Bos taurus)
RHEA:19432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[beta-adrenergic receptor] + ATP <=> [beta-adrenergic receptor]-phosphate + ADP + H(+)
REACT:R-DRE-8938853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 binds RUNX1 (Danio rerio)
REACT:R-MMU-3927824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CASP8AP2 with SUMO1 (Mus musculus)
RHEA:53614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-D-ribulose + diphosphate => CTP + D-ribulose 5-phosphate + H(+)
RHEA:63966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,12Z)-hexadecadienal + phosphoethanolamine => sphinga-4E,14Z-dienine-1-phosphate
GO:0030751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity
GO:0030751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	licodione 2'-O-methyltransferase activity
REACT:R-RNO-5625784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Rattus norvegicus)
RHEA:56523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine
REACT:R-HSA-177936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Homo sapiens)
RHEA:48234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde => acetyl-CoA + L-glutamate 5-semialdehyde
RHEA:30696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal + H2O + NAD(+) => beta-alanine + 2 H(+) + NADH
REACT:R-CFA-1454791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP7, MMP9 bind CD44 (Canis familiaris)
REACT:R-MMU-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Mus musculus)
REACT:R-CEL-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Caenorhabditis elegans)
RHEA:49425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + validone => ADP + H(+) + validone 7-phosphate
RHEA:36925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA
RHEA:43446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-ditetradecanoyl-sn-glycerol + ATP
RHEA:55936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + H(+) + NADH
GO:0008868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactitol-1-phosphate:NAD+ oxidoreductase activity
GO:0008868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol-1-phosphate 5-dehydrogenase activity
REACT:R-RNO-76453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A6 (Rattus norvegicus)
REACT:R-HSA-9021182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 mRNA binds miR-132 RISC (Homo sapiens)
REACT:R-DRE-8931653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Danio rerio)
REACT:R-DME-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-DRE-75083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Danio rerio)
REACT:R-MMU-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Mus musculus)
REACT:R-SSC-9012349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)
RHEA:16625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hydrogen sulfide = CoA + thioacetate
RHEA:16625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrogen-sulfide S-acetyltransferase"
RHEA:16625	skos:prefLabel	"hydrogen-sulfide S-acetyltransferase"
REACT:R-HSA-163099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)
RHEA:61747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolbioside + UDP-alpha-D-glucose <=> stevioside + UDP
RHEA:71875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) + taurocholate(in)
REACT:R-DRE-75886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Danio rerio)
REACT:R-XTR-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Xenopus tropicalis)
RHEA:44451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + CoA
REACT:R-DRE-110354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of OGG1 glycosylase by APEX1 at the AP site (Danio rerio)
RHEA:41395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)
REACT:R-HSA-193961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Homo sapiens)
REACT:R-HSA-997314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of JAK1 by SHP1 (Homo sapiens)
RHEA:13065	skos:prefLabel	"peroxisome-assembly ATPase"
RHEA:13065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peroxisome-assembly ATPase"
RHEA:13065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O = ADP + H(+) + phosphate
RHEA:13065	skos:altLabel	"peroxisome assembly factor-2"
RHEA:14951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2 => A + H2O + quinoline-4-carboxylate
REACT:R-DRE-9794008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC binds CFLAR (Danio rerio)
REACT:R-HSA-1248002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of EGFRvIII mutant (Homo sapiens)
GO:0033776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetone monooxygenase activity
GO:0033776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylacetone,NADPH:oxygen oxidoreductase activity
GO:0033776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAMO
RHEA:54868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-[ACP] + H(+) + NADH = butanoyl-[ACP] + NAD(+)
REACT:R-DDI-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Dictyostelium discoideum)
RHEA:48667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)
GO:0035447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA:Cys-GlcN-Ins acetyltransferase
GO:0035447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycothiol synthase activity
REACT:R-SSC-448673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of caspase-1 p10/p20 dimer (Sus scrofa)
RHEA:38741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol
REACT:R-BTA-5654169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 (Bos taurus)
RHEA:41183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
GO:0018674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0018674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene 3-hydroxylase activity
GO:0018674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-limonene 3-monooxygenase"
GO:0018674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)
GO:0018674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-limonene 3-hydroxylase activity
GO:0018674	skos:altLabel	"(-)-limonene 3-hydroxylase"
GO:0018674	skos:prefLabel	"(S)-limonene 3-monooxygenase"
GO:0018674	skos:altLabel	"CYP71D15"
GO:0018674	skos:altLabel	"(-)-limonene 3-monooxygenase"
GO:0018674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-limonene 3-monooxygenase activity
GO:0018674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity
GO:0018674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-limonene 3-monooxygenase activity
REACT:R-HSA-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Homo sapiens)
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin 3 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neurotrophin TRKA receptor activity
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NT4 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NT5 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neurotrophin TRKB receptor activity
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin-4/5 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin 4/5 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NT-4 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NT 4/5 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotrophic factor binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin-3 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotrophin binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NT-4/5 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NT-3 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neurotrophin TRK receptor activity
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NT3 binding
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neurotrophin TRKC receptor activity
GO:0043121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NT-5 binding
REACT:R-HSA-4084980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Homo sapiens)
REACT:R-PFA-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Plasmodium falciparum)
REACT:R-XTR-1067667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R (Xenopus tropicalis)
RHEA:26028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine + O2 => 3-aminopropanal + H2O2 + N-acetylputrescine
GO:0038182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled bile acid receptor activity
GO:0038182	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cell surface bile acid receptor
GO:0038182	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	membrane bile acid receptor activity
GO:0038182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled bile acid receptor activity
REACT:R-BTA-6784861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG binds LPL dimer (Bos taurus)
REACT:R-HSA-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Homo sapiens)
RHEA:62826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose
RHEA:64417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylofuranose + NADP(+) => D-xylono-1,4-lactone + H(+) + NADPH
REACT:R-RNO-380278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Rattus norvegicus)
REACT:R-BTA-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
RHEA:15198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-2179415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Canis familiaris)
REACT:R-RNO-5682983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates WHSC1 (Rattus norvegicus)
REACT:R-MMU-5690827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 (Mus musculus)
RHEA:37249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + thymidine => H2O + thymidine 3'-monophosphate
REACT:R-XTR-2213241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of nonameric complex (Xenopus tropicalis)
REACT:R-MMU-3769401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKK and KRM bind LRP5/6 (Mus musculus)
REACT:R-BTA-2161779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LXA4 is oxidised to 15k-LXA4 by HPGD (Bos taurus)
REACT:R-SCE-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Saccharomyces cerevisiae)
EC:3.1.1.74	skos:altLabel	"cutin hydrolase"
EC:3.1.1.74	skos:prefLabel	"cutinase"
EC:3.1.1.74	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cutinase"
REACT:R-DRE-446391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the PINCH-ILK-parvin complex (Danio rerio)
REACT:R-HSA-5654684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)
REACT:R-PFA-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Plasmodium falciparum)
GO:0010473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity
REACT:R-RNO-388560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA,EDNRB bind EDNs (Rattus norvegicus)
RHEA:17463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate + phosphate => D-sedoheptulose 1,7-bisphosphate + H2O
RHEA:61614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-epi-cylindrospermopsin + CO2 + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2
RHEA:45801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-demethylaclacinomycin T + AH2 + O2 => 10-decarboxymethylaclacinomycin T + A + CO2 + H2O
RHEA:43922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:33397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + N(alpha)-acetyl-L-lysine methyl ester => H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester
REACT:R-GGA-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Gallus gallus)
RHEA:69688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein 7-O-beta-D-glucoside + H2O => beta-D-glucose + genistein
RHEA:31152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-selenocystathionine => 2-oxobutanoate + L-selenocysteine + NH4(+)
REACT:R-CFA-5656070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFBPs bind FGFs (Canis familiaris)
REACT:R-GGA-9011952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Gallus gallus)
RHEA:17335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + L-lupinate => O-acetyl-L-serine + zeatin
REACT:R-GGA-158722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Gallus gallus)
RHEA:69255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> 2-(thiiran-2-yl)acetonitrile + sulfate
GO:0004610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-N-acetylglucosamine mutase activity
GO:0004610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate
GO:0004610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoacetylglucosamine mutase activity
GO:0004610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoacetylglucosamine mutase"
GO:0004610	skos:altLabel	"N-acetylglucosamine-phosphate mutase"
GO:0004610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglucosamine phosphomutase activity
GO:0004610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity
GO:0004610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-glucosamine 1,6-phosphomutase activity
GO:0004610	skos:altLabel	"acetylglucosamine phosphomutase"
GO:0004610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosamine-phosphate mutase activity
GO:0004610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylaminodeoxyglucose phosphomutase activity
GO:0004610	skos:prefLabel	"phosphoacetylglucosamine mutase"
GO:0008046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor activity involved in axon guidance
GO:0008046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	axon guidance receptor activity
REACT:R-CFA-5334854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAR:RXR binds SUMO-CRABP2:atRA (Canis familiaris)
RHEA:35405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-vestitone + H(+) + NADPH => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+)
REACT:R-DME-2424477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)
REACT:R-CFA-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)
REACT:R-RNO-9710353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds cardiolipin (Rattus norvegicus)
RHEA:43412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-galactosylceramide + H2O = an N-acyl-sphingoid base + D-galactose
RHEA:46765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9677320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS1 dimer binds PTGS1 Inhibitors (Homo sapiens)
REACT:R-RNO-5672027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)
REACT:R-BTA-1236958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of particulate antigens with dendritic cell receptors (Bos taurus)
REACT:R-CFA-5603114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)
REACT:R-CFA-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Canis familiaris)
REACT:R-GGA-9034855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK3 (Gallus gallus)
REACT:R-DRE-877269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS-1 and SOCS-3 binds to p-JAK2 (Danio rerio)
REACT:R-CEL-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Caenorhabditis elegans)
REACT:R-HSA-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate reductase (NADPH) activity
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triphosphopyridine nucleotide-nitrate reductase activity
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate reductase (NADPH(2)) activity
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:nitrate reductase activity
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	assimilatory nitrate reductase activity
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate reductase (NADPH2)
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:nitrate oxidoreductase activity
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-nitrate reductase activity
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite:NADP+ oxidoreductase activity
GO:0050464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	assimilatory NADPH-nitrate reductase activity
REACT:R-BTA-6810643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPPIN protein complex binds bacteria (Bos taurus)
REACT:R-HSA-9755937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces LAN to 24,25-dhLAN (Homo sapiens)
REACT:R-BTA-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Bos taurus)
REACT:R-DME-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Drosophila melanogaster)
RHEA:48527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GP1c + H2O <=> ganglioside GQ1c + N-acetylneuraminate
RHEA:47139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + lithocholate <=> AMP + diphosphate + lithocholoyl-CoA
RHEA:53414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2
REACT:R-HSA-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Homo sapiens)
RHEA:61437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H2O => AMP + H(+) + phosphate
REACT:R-SSC-1112604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STATs are released (Sus scrofa)
RHEA:55384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate
REACT:R-GGA-442913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3  (Gallus gallus)
RHEA:18684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine <=> phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
REACT:R-SSC-8852716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin, ELANE cleave C5 (Sus scrofa)
REACT:R-CEL-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Caenorhabditis elegans)
REACT:R-MMU-9701531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727 STAT3 is acetylated (Mus musculus)
REACT:R-HSA-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Homo sapiens)
REACT:R-CFA-209903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline is converted to adrenaline (Canis familiaris)
REACT:R-HSA-2162194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2 (Homo sapiens)
REACT:R-XTR-352029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Xenopus tropicalis)
GO:0106324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)
GO:0106324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-limonene 1,2-monooxygenase NADH activity
RHEA:11709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP + NAD(+) => H(+) + NADH + XMP
REACT:R-DME-1454781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Drosophila melanogaster)
REACT:R-RNO-6798257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRS binds NTRK3 (Rattus norvegicus)
RHEA:18499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylulose 5-phosphate => L-ribulose 5-phosphate
RHEA:44413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-10 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-10
GO:0032357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized purine base DNA binding
GO:0032357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized purine DNA binding
GO:0032357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidised purine DNA binding
GO:0032357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized purine nucleobase DNA binding
REACT:R-HSA-6789208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOCl-induced glycosaminoglycan fragmentation (Homo sapiens)
REACT:R-XTR-77609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of APOBEC-1 to form editosome (Xenopus tropicalis)
REACT:R-DRE-5684008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBN binds KPNA2 (Danio rerio)
REACT:R-CEL-429415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
REACT:R-DRE-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Danio rerio)
RHEA:39490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O
REACT:R-SSC-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Sus scrofa)
REACT:R-HSA-6791291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates BID gene expression (Homo sapiens)
REACT:R-RNO-159752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Rattus norvegicus)
RHEA:37827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate
REACT:R-DME-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Drosophila melanogaster)
REACT:R-HSA-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Homo sapiens)
RHEA:22626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + pyruvate => (S)-4-hydroxy-2-oxopentanoate
RHEA:36707	skos:prefLabel	"O-ureido-serine racemase"
RHEA:36707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-ureido-serine racemase"
RHEA:36707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-ureido-L-serine = O-ureido-D-serine
REACT:R-CFA-213175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 oxidise AFB1 to AFXBO (Canis familiaris)
GO:0046966	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	thyroid hormone receptor binding
GO:0046966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear thyroid hormone receptor binding
GO:0046966	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ligand-dependent thyroid hormone receptor interactor activity
REACT:R-DME-6788523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to Complex I subunits (Drosophila melanogaster)
REACT:R-BTA-2046222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Bos taurus)
REACT:R-CFA-879222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP:NLRP1 binds ATP (Canis familiaris)
RHEA:22268	skos:altLabel	"streptidine kinase"
RHEA:22268	skos:altLabel	"APH(6)"
RHEA:22268	skos:prefLabel	"streptomycin 6-kinase"
RHEA:22268	skos:altLabel	"streptomycin 6-phosphotransferase"
RHEA:22268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin = ADP + H(+) + streptomycin 6-phosphate
RHEA:22268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"streptomycin 6-kinase"
REACT:R-MMU-6801195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3 binds BNIP3L (Mus musculus)
REACT:R-SSC-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Sus scrofa)
REACT:R-HSA-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Homo sapiens)
REACT:R-HSA-9714924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to soluble TNF trimer (Homo sapiens)
RHEA:64370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2 => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A
RHEA:24000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]
RHEA:72118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(out) + Na(+)(out) <=> glycine betaine(in) + Na(+)(in)
RHEA:43067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate
REACT:R-HSA-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Homo sapiens)
RHEA:41060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA
RHEA:63548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin-(1-9) + H2O = angiotensin-(1-7) + L-phenylalanyl-L-histidine
REACT:R-BTA-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Bos taurus)
RHEA:57777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-6-nitrotoluene + NADH + O2 => 4-chloro-3-methylcatechol + NAD(+) + nitrite
REACT:R-HSA-6789960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of NDN,TP53 (Homo sapiens)
RHEA:26021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O
REACT:R-MMU-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Mus musculus)
RHEA:50598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4] => acetyl-CoA + N-terminal L-seryl-[histone H4]
RHEA:52724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate = a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)
RHEA:52724	skos:prefLabel	"aliphatic desulfoglucosinolate sulfotransferase"
RHEA:52724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aliphatic desulfoglucosinolate sulfotransferase"
REACT:R-DRE-139906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of BAD by calcineurin (Danio rerio)
REACT:R-HSA-6804006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NO and NO2 react to N2O3 (Homo sapiens)
REACT:R-BTA-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Bos taurus)
REACT:R-MMU-2424243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Mus musculus)
GO:0052580	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-menthone:NADP+ oxidoreductase activity
GO:0052580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-pulegone reductase, (-)-menthone as substrate, activity
RHEA:44143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate <=> acetyl-CoA + CO2 + reduced [flavodoxin]
RHEA:14130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH
REACT:R-CFA-1678841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Canis familiaris)
RHEA:11135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + NADP(+) <=> H(+) + NADPH + protochlorophyllide a
REACT:R-SSC-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Sus scrofa)
REACT:R-HSA-1676041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome (Homo sapiens)
RHEA:22713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide phosphate + GTP + H(+) => adenosylcob(III)inamide-GDP + diphosphate
REACT:R-CFA-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Canis familiaris)
REACT:R-SSC-6799178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 1 binds HP subcomplex to form Intermediate 2 (Sus scrofa)
REACT:R-CFA-741386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 induces K63-linked ubiquitination of NEMO (Canis familiaris)
REACT:R-MMU-430190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds NCK (Mus musculus)
REACT:R-DRE-3221982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANP binds TP53 (Danio rerio)
RHEA:48841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
RHEA:60276	skos:prefLabel	"[histone H3]-lysine(9) N-trimethyltransferase"
RHEA:60276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(9) N-trimethyltransferase"
RHEA:60276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine
RHEA:29736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butane-1-sulfonate + FMNH2 + O2 => butanal + FMN + 2 H(+) + H2O + sulfite
RHEA:36497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-glucose 6-phosphate + H(+) => alpha-D-glucose + ATP
REACT:R-MMU-2046265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the keratan chain (Mus musculus)
RHEA:36975	skos:prefLabel	"AMP phosphorylase"
RHEA:36975	skos:altLabel	"nucleoside monophosphate phosphorylase"
RHEA:36975	skos:altLabel	"AMPpase"
RHEA:36975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"AMP phosphorylase"
RHEA:36975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate
RHEA:66657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(out) + L-ascorbate(in) => Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)
RHEA:49286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate => 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP
GO:0031833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 7 serotonin receptor binding
GO:0031833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 7 receptor binding
GO:0031833	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 7 serotonin receptor ligand
REACT:R-HSA-8935864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-302b binds RUNX1 mRNA (Homo sapiens)
REACT:R-HSA-6801087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the RABGGTA gene (Homo sapiens)
REACT:R-HSA-3200023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ETS1 binds p16INK4A promoter (Homo sapiens)
REACT:R-XTR-2162002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Xenopus tropicalis)
REACT:R-GGA-8987150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Gallus gallus)
GO:0015046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rubredoxin-NADP+ reductase activity
GO:0015046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [rubredoxin] = NADPH + 2 oxidized [rubredoxin]
RHEA:47633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine + NAD(+) => 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)
RHEA:62806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desertorin A + 2 H2O + NADP(+) => 2 7-demethylsiderin + NADPH + O2
REACT:R-DRE-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Danio rerio)
REACT:R-SSC-8853737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Sus scrofa)
REACT:R-MMU-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Mus musculus)
REACT:R-DRE-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Danio rerio)
RHEA:44705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:10219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DNA-directed RNA polymerase] + ATP <=> ADP + H(+) + phospho-[DNA-directed RNA polymerase]
RHEA:39554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)
REACT:R-RNO-373813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR2 binds ligands CXCL1 to 7 (Rattus norvegicus)
REACT:R-SSC-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Sus scrofa)
RHEA:48881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + CO + H2O => a quinol + CO2
GO:0019145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobutanal dehydrogenase activity
GO:0019145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ABAL dehydrogenase activity
GO:0019145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminobutyraldehyde dehydrogenase activity
GO:0019145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobutyraldehyde dehydrogenase activity
GO:0019145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobutanal:NAD+ 1-oxidoreductase activity
GO:0019145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-aminobutyraldehyde dehydroganase activity
GO:0102121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ceramidase"
GO:0102121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramidase activity
GO:0102121	skos:altLabel	"acylsphingosine deacylase"
GO:0102121	skos:prefLabel	"ceramidase"
GO:0102121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine
REACT:R-CFA-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Canis familiaris)
REACT:R-SSC-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Sus scrofa)
RHEA:52826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2
REACT:R-SSC-5205820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)
REACT:R-CEL-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Caenorhabditis elegans)
RHEA:38739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol
RHEA:51842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + tauroallocholate(in) => 2 Na(+)(out) + tauroallocholate(out)
REACT:R-CFA-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Canis familiaris)
RHEA:27501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-di-O-methyltricetin + S-adenosyl-L-methionine = 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine
RHEA:53305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 2 ATP + 2 cob(II)alamin => A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate
REACT:R-HSA-210921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEUROG3-dependent synthesis of NKX2-2 (Homo sapiens)
GO:0000253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-KSR activity
GO:0000253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-steroid:NADP+ 3-oxidoreductase
GO:0000253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-keto-steroid reductase activity
GO:0000253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-keto sterol reductase activity
REACT:R-RNO-1358795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitination of RNF41 by P-USP8 (Rattus norvegicus)
REACT:R-BTA-9733973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts bind FABP6 (Bos taurus)
EC:1.8.3.5	skos:altLabel	"prenylcysteine lyase"
EC:1.8.3.5	skos:prefLabel	"prenylcysteine oxidase"
EC:1.8.3.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prenylcysteine oxidase"
REACT:R-SSC-5628905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Sus scrofa)
REACT:R-DME-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)
REACT:R-RNO-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Rattus norvegicus)
REACT:R-MMU-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Mus musculus)
RHEA:31027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl trans-(+)-abscisate + UDP
REACT:R-DDI-3000433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PML with SUMO3 (Dictyostelium discoideum)
GO:0102303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	resveratrol 3,5-O-dimethyltransferase activity
REACT:R-CFA-202216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 (Canis familiaris)
REACT:R-RNO-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Rattus norvegicus)
REACT:R-CFA-211193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization  of DFF40 (Canis familiaris)
REACT:R-HSA-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Homo sapiens)
REACT:R-HSA-2395876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
REACT:R-GGA-8938121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds CTSK (Gallus gallus)
REACT:R-BTA-8850539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GNB5:RGS dimers from CCT/TRiC (Bos taurus)
REACT:R-RNO-5368586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKK promotes clathrin-dependent internalization of LRP6 (Rattus norvegicus)
REACT:R-CFA-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Canis familiaris)
RHEA:61110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:69025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-hydroxy-L-aspartate + NADPH + O2 => H2O + N,N-dihydroxy-L-aspartate + NADP(+)
RHEA:70715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) = glycine(out)
GO:0035804	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	structural constituent of zona pellucida
GO:0035804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of egg coat
GO:0035804	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	structural constituent of vitelline envelope
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamate 4-hydroxylase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylase, cinnamate 4-
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P450 cinnamate 4-hydroxylase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CA4H activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-cinnamate 4-monooxygenase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamate hydroxylase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamic acid p-hydroxylase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamic acid 4-monooxygenase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamic acid 4-hydroxylase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-cinnamic acid 4-hydroxylase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-cinnamate 4-hydroxylase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	t-cinnamic acid hydroxylase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamic 4-hydroxylase activity
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxygenase, cinnamate 4-mono-
GO:0016710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamate 4-monooxygenase activity
REACT:R-HSA-5607741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p52:RELB translocates from cytosol to nucleus (Homo sapiens)
REACT:R-CEL-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
RHEA:13757	skos:prefLabel	"N-hydroxythioamide S-beta-glucosyltransferase"
RHEA:13757	skos:altLabel	"desulfoglucosinolate-uridine diphosphate glucosyltransferase"
RHEA:13757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-desulfoglucotropeolin + UDP
RHEA:13757	skos:altLabel	"thiohydroximate beta-D-glucosyltransferase"
RHEA:13757	skos:altLabel	"thiohydroximate glucosyltransferase"
RHEA:13757	skos:altLabel	"thiohydroximate S-glucosyltransferase"
RHEA:13757	skos:altLabel	"uridine diphosphoglucose-thiohydroximate glucosyltransferase"
RHEA:13757	skos:altLabel	"UGT74B1"
RHEA:13757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-hydroxythioamide S-beta-glucosyltransferase"
REACT:R-RNO-176521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Rattus norvegicus)
RHEA:44776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-6 + S-adenosyl-L-methionine = H(+) + menaquinol-6 + S-adenosyl-L-homocysteine
RHEA:45171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (E)-sinapoyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine
RHEA:53828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate
RHEA:65082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane D + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:66433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-galactose(out) => H(+)(in) + L-galactose(in)
RHEA:46489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)
EC:1.14.14.14	skos:altLabel	"CYP19A1"
EC:1.14.14.14	skos:altLabel	"estrogen synthetase"
EC:1.14.14.14	skos:prefLabel	"aromatase"
EC:1.14.14.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aromatase"
REACT:R-BTA-392187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated P2Y purinoceptor 12 binds G-protein Gi (Bos taurus)
REACT:R-BTA-8949668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YME1L1 proteolyzes unassembled proSMDT1 (Bos taurus)
REACT:R-GGA-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Gallus gallus)
RHEA:49760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDTA + FMNH2 + O2 = ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O
RHEA:18814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate => (3E,5R)-5-carboxy-2-oxohept-3-enedioate
RHEA:67940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2
RHEA:33231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + heme b = heme d cis-diol
RHEA:18225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[N-(6-aminohexanoyl)](n) + H2O = 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)
REACT:R-BTA-8957265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades TP73 polyubiquitinated by ITCH (Bos taurus)
RHEA:11964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol
RHEA:53796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholoyl-CoA + ursodeoxycholate = deoxycholate + ursodeoxycholoyl-CoA
RHEA:68288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptanoyl-CoA + L-seryl-[protein] = CoA + O-heptanoyl-L-seryl-[protein]
RHEA:13702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-homoserine => CoA + O-acetyl-L-homoserine
REACT:R-DRE-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Danio rerio)
REACT:R-SSC-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Sus scrofa)
REACT:R-DDI-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Dictyostelium discoideum)
REACT:R-GGA-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Gallus gallus)
RHEA:40966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 2-aminophenol + 3 O2 <=> 2 2-aminophenoxazin-3-one + 6 H2O
RHEA:14602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + O2 => 5-aminopentanamide + CO2 + H2O
REACT:R-BTA-211881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A13 (Bos taurus)
RHEA:57193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glycolate + H(+) + L-lysyl-[protein]
REACT:R-XTR-8852809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPN, CPB2 cleave C3a, C5a (Xenopus tropicalis)
REACT:R-XTR-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Xenopus tropicalis)
REACT:R-DRE-1168894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A/B dissociates from the Growth Hormone receptor (Danio rerio)
RHEA:15657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase"
RHEA:15657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO2 + NADH
RHEA:15657	skos:prefLabel	"1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase"
REACT:R-BTA-5696564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP25 deubiquitinates DDX58 (Bos taurus)
REACT:R-HSA-163770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX (Homo sapiens)
RHEA:69458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+) => 3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH
RHEA:32333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-fenchone + H(+) + NADH => (1S,2S,4R)-endo-fenchol + NAD(+)
RHEA:64767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol
REACT:R-HSA-9670418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 downstream of KIT mutants (Homo sapiens)
REACT:R-CFA-192065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
RHEA:59894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + H(+) + L-propargylglycine => L-2-amino-4-chloropent-4-enoate
REACT:R-SSC-2076611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3STs sulfate GlcN at C3 in heparan sulfate (Sus scrofa)
RHEA:41463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacylglycerol + a sphingomyelin
REACT:R-HSA-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)
REACT:R-SSC-159757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)
REACT:R-RNO-5649764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Rattus norvegicus)
RHEA:47599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP
REACT:R-SCE-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Saccharomyces cerevisiae)
REACT:R-DRE-2404200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2 binds IGF1R (Danio rerio)
REACT:R-HSA-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
RHEA:44546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(in) + ADP + H(+) + phosphate => a fatty acid(out) + ATP + H2O
RHEA:41717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine
RHEA:60297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-SSC-5225602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR5 binds Me2sR3-replicative histone H3 (Sus scrofa)
REACT:R-DRE-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Danio rerio)
REACT:R-SSC-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Sus scrofa)
RHEA:53390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate
RHEA:44016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) = 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH
REACT:R-SCE-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Saccharomyces cerevisiae)
REACT:R-RNO-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Rattus norvegicus)
RHEA:65813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 => A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA
REACT:R-GGA-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Gallus gallus)
REACT:R-MMU-5671763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates PPP1R14A (Mus musculus)
GO:0052891	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	oxynitrilase activity
GO:0052891	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(S)-cyanohydrin producing hydroxynitrile lyase activity
GO:0052891	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxynitrile lyase activity
GO:0052891	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(S)-selective hydroxynitrile lyase activity
GO:0052891	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(S)-oxynitrilase activity
GO:0052891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aliphatic (S)-hydroxynitrile lyase activity
GO:0052891	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(S)-hydroxynitrile lyase activity
GO:0052891	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity
REACT:R-GGA-9632868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1B is phosphorylated in response to estrogen (Gallus gallus)
REACT:R-MMU-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Mus musculus)
RHEA:57393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine => 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)
REACT:R-DRE-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Danio rerio)
REACT:R-MMU-212263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 trimethylates histone H3 at lysine-27 (Mus musculus)
REACT:R-MMU-190388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3c (Mus musculus)
RHEA:24677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cytidine <=> ADP + CMP + H(+)
RHEA:13615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1,6-bisphosphate + H(+) + phosphate => beta-D-fructose 6-phosphate + diphosphate
RHEA:22629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate
REACT:R-DRE-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Danio rerio)
RHEA:13090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) => 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite
REACT:R-HSA-167597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
REACT:R-BTA-8862380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B13 binds lipid droplets (Bos taurus)
RHEA:66785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) => 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]
RHEA:66477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenate + UDP-alpha-D-glucose => gypsogenate 28-beta-D-glucoside + UDP
REACT:R-CFA-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Canis familiaris)
REACT:R-CFA-418874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
REACT:R-CFA-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Canis familiaris)
RHEA:13896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate <=> ADP + AMP + 2 H(+)
REACT:R-DRE-9706399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 hydrolyzes ATP (Danio rerio)
RHEA:28449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose(in) <=> 1-deoxy-D-xylulose(out)
REACT:R-RNO-9709360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 reduces MetHb (Rattus norvegicus)
GO:0016019	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peptidoglycan recognition activity
GO:0016019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan immune receptor activity
GO:0016019	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	peptidoglycan receptor activity
GO:0032029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin tail binding
GO:0102414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin-3-O-glucoside 1,6-glucosyltransferase activity
RHEA:68991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:31415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphate
RHEA:64516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate + NAD(+) = H(+) + NADH + sulfoacetaldehyde
RHEA:45877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-CFA-6814674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Canis familiaris)
REACT:R-DRE-174105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated cell cycle proteins (Danio rerio)
RHEA:40454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)
RHEA:50672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O = [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose
REACT:R-XTR-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Xenopus tropicalis)
REACT:R-DME-2187401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 dephosphorylates SMAD2/3 (Drosophila melanogaster)
RHEA:10535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine <=> D-glyceraldehyde 3-phosphate + H2O + L-tryptophan
REACT:R-CFA-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Canis familiaris)
RHEA:39847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + ATP = a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)
REACT:R-CEL-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Caenorhabditis elegans)
REACT:R-CFA-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Canis familiaris)
RHEA:28615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1Z,2S)-2-methylbutanal oxime => (2S)-2-methylbutanenitrile + H2O
RHEA:60257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + L-lysyl(4)-[histone H3]
RHEA:49198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol
REACT:R-CFA-5695964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD14B hydrolyses PNPB (Canis familiaris)
REACT:R-MMU-202110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1 complex binds to CaM (Mus musculus)
RHEA:28899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + H(+)(in) = glycine(out) + H(+)(out)
RHEA:29755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate(in) = (R)-lipoate(out)
REACT:R-DRE-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Danio rerio)
REACT:R-SSC-879930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 is recruited by JAK2 (Sus scrofa)
RHEA:49810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + butanal => a quinone + butan-1-ol
REACT:R-XTR-5205824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Xenopus tropicalis)
GO:0102372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-amyrin 28-monooxygenase activity
RHEA:70070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Xenopus tropicalis)
RHEA:37566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
RHEA:43500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + H(+) + NADH
REACT:R-GGA-5696945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates CCP110,ARRB (Gallus gallus)
REACT:R-RNO-8848818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CBL (Rattus norvegicus)
REACT:R-MMU-4341025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR3C1 (GR) with SUMO1 (Mus musculus)
RHEA:45377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine
RHEA:14354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate 6-phosphate + H(+) => CO2 + L-xylulose 5-phosphate
RHEA:70398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + docosanoyl-CoA <=> CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine
RHEA:29957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + thymidine(out) => H(+)(in) + thymidine(in)
RHEA:63428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + levoglucosan = ADP + D-glucose 6-phosphate + H(+)
RHEA:63428	skos:prefLabel	"levoglucosan kinase"
RHEA:63428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"levoglucosan kinase"
GO:0047135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 gamma-L-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH
GO:0047135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity
GO:0047135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis-g-glutamylcystine reductase (NADPH) activity
GO:0047135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bis-gamma-glutamylcystine reductase"
GO:0047135	skos:altLabel	"bis-gamma-glutamylcystine reductase (NADPH)"
GO:0047135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bis-gamma-glutamylcystine reductase (NADPH) activity
GO:0047135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis-gamma-glutamylcystine reductase activity
GO:0047135	skos:altLabel	"NADPH:bis-gamma-glutamylcysteine oxidoreductase"
GO:0047135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamylcysteine:NADP+ oxidoreductase activity
GO:0047135	skos:prefLabel	"bis-gamma-glutamylcystine reductase"
GO:0047135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Bis-gamma-glutamylcystine reductase (NADPH)
GO:0047135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:bis-gamma-glutamylcysteine oxidoreductase activity
REACT:R-BTA-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Bos taurus)
REACT:R-SCE-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Saccharomyces cerevisiae)
REACT:R-CFA-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Canis familiaris)
RHEA:23403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxykynurenate + O2 <=> 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)
REACT:R-CFA-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Canis familiaris)
RHEA:42649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2,5-ethylene furandicarboxylate)(n) + 2 H2O => (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)
REACT:R-RNO-389463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteinase-activated receptors can bind thrombin (Rattus norvegicus)
RHEA:44162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + phosphate => 1D-myo-inositol 6-phosphate + H2O
RHEA:68040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lanthionine ketimine + 2 H(+) + NADPH = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)
REACT:R-SSC-448427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 binds Interleukin-27 receptor (Sus scrofa)
REACT:R-SSC-390250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Sus scrofa)
REACT:R-XTR-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Xenopus tropicalis)
REACT:R-CFA-1483096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA is dephosphorylated to ETA by PHOSPHO1 (Canis familiaris)
REACT:R-DRE-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Danio rerio)
REACT:R-SSC-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Sus scrofa)
RHEA:65850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a steroid 1,3-dione + AH2 => A + a 3-oxo-Delta(1)-steroid + H2O
REACT:R-BTA-3343700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)
RHEA:30440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)
REACT:R-RNO-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Rattus norvegicus)
RHEA:57512	skos:prefLabel	"chlorobenzene dioxygenase"
RHEA:57512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorobenzene dioxygenase"
RHEA:57512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorobenzene + H(+) + NADH + O2 = (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)
RHEA:63942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2
RHEA:48533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GQ1c (d18:1(4E)) + H2O => ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate
RHEA:52613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-5690080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)
REACT:R-CFA-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)
RHEA:30607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-phytofluene = AH2 + all-trans-zeta-carotene
RHEA:50461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + ATP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + diphosphate
REACT:R-SPO-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)
REACT:R-CFA-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Canis familiaris)
REACT:R-RNO-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)
GO:0001648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteinase activated receptor activity
GO:0001648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protease-activated receptor activity
GO:0001648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteinase-activated receptor activity
RHEA:22880	skos:altLabel	"prephenate transaminase"
RHEA:22880	skos:prefLabel	"glutamate--prephenate aminotransferase"
RHEA:22880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate--prephenate aminotransferase"
RHEA:22880	skos:altLabel	"PAT"
RHEA:22880	skos:altLabel	"L-glutamate:prephenate aminotransferase"
RHEA:22880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arogenate = L-glutamate + prephenate
GO:0050192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphate phosphatase activity
GO:0050192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-2-phosphoglycerate phosphatase activity
GO:0050192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglycerate phosphatase activity
GO:0050192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glycerate-2-phosphate phosphohydrolase activity
RHEA:22665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-O-(trans-sinapoyl)-beta-D-glucose => 1,2-di-O-sinapoyl beta-D-glucose + D-glucose
GO:0047976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-hamamelose 2'-phosphotransferase activity
GO:0047976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP/hamamelose 2'-phosphotransferase activity
GO:0047976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hamamelose kinase (phosphorylating)
GO:0047976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hamamelose kinase activity
GO:0047976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acetyl-L-homoserine sulfhydrolase activity
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine biosynthetic process, direct, from O-acetyl-L-homoserine
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OAH sulfhydrylase activity
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity
GO:0003961	skos:altLabel	"O-acetyl-L-homoserine sulfhydrolase"
GO:0003961	skos:altLabel	"O-acetyl-L-homoserine acetate-lyase (adding methanethiol)"
GO:0003961	skos:altLabel	"methionine synthase"
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine anabolism, direct, from O-acetyl-L-homoserine
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acetylhomoserine sulfhydrolase activity
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine
GO:0003961	skos:altLabel	"OAH sulfhydrylase"
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-acetyl-L-homoserine = acetate + L-homocysteine
GO:0003961	skos:altLabel	"O-acetylhomoserine (thiol)-lyase"
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine formation, direct, from O-acetyl-L-homoserine
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-acetylhomoserine aminocarboxypropyltransferase"
GO:0003961	skos:altLabel	"O-acetylhomoserine sulfhydrolase"
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetylhomoserine (thiol)-lyase activity
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanethiol + O-acetyl-L-homoserine = acetate + H(+) + L-methionine
GO:0003961	skos:prefLabel	"O-acetylhomoserine aminocarboxypropyltransferase"
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetylhomoserine aminocarboxypropyltransferase activity
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity
GO:0003961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine synthesis, direct, from O-acetyl-L-homoserine
REACT:R-SSC-193787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Sus scrofa)
RHEA:30359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 = chlorophyllide b + 3 H2O + 2 NADP(+)
RHEA:30359	skos:prefLabel	"chlorophyllide a oxygenase"
RHEA:30359	skos:altLabel	"cholorophyll-b synthase"
RHEA:30359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorophyllide a oxygenase"
RHEA:30359	skos:altLabel	"CAO"
RHEA:15913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiamine-phosphate kinase"
RHEA:15913	skos:altLabel	"Thiamine-monophosphate kinase"
RHEA:15913	skos:prefLabel	"thiamine-phosphate kinase"
RHEA:15913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine phosphate = ADP + thiamine diphosphate
REACT:R-HSA-933532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processing of caspases (Homo sapiens)
REACT:R-BTA-8936584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)
RHEA:25299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H2O + NADP(+) => acetate + 2 H(+) + NADPH
REACT:R-RNO-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Rattus norvegicus)
RHEA:67170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-phenylalanine
REACT:R-BTA-430183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK binds PAK (Bos taurus)
REACT:R-BTA-9707690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 binds MAFK (Bos taurus)
REACT:R-DME-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Drosophila melanogaster)
REACT:R-MMU-9697747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)
REACT:R-MMU-8942101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 monoubiquitinates Histone H2B (Mus musculus)
RHEA:16410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydrovomilenine + NADP(+) => H(+) + NADPH + vomilenine
REACT:R-HSA-9636397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtpA binds ATP6V1H (Homo sapiens)
REACT:R-DRE-3262512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Danio rerio)
REACT:R-BTA-9663511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds GSTA1, FABP1 (Bos taurus)
REACT:R-BTA-391158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP alpha binds CD47 (Bos taurus)
REACT:R-MMU-8938951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PAX5 (BSAP) (Mus musculus)
REACT:R-MMU-3000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PLK1 (Mus musculus)
REACT:R-SSC-141186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD oxidatively deaminates of 5HT (Sus scrofa)
REACT:R-BTA-2066778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Bos taurus)
REACT:R-HSA-4411402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NLK (Homo sapiens)
RHEA:31078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O
REACT:R-XTR-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Xenopus tropicalis)
REACT:R-DRE-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Danio rerio)
REACT:R-CFA-870269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gastrin binds to CCK-B receptor (Canis familiaris)
REACT:R-HSA-560473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ANGPTL4 (Homo sapiens)
RHEA:66087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + oxaloacetate <=> H2O + kynurenate + L-aspartate
REACT:R-HSA-1235035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Carbonic Anhydrase IX (CA9) (Homo sapiens)
GO:0004858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP pyrophosphatase inhibitor activity
RHEA:72424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-AMP + CoA => (E)-4-coumaroyl-CoA + AMP + H(+)
REACT:R-MMU-9656893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1MW binds 11cRAL (Mus musculus)
RHEA:26565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-succinylbenzoyl-CoA + H(+) <=> 1,4-dihydroxy-2-naphthoyl-CoA + H2O
REACT:R-RNO-5687465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds RBBP8 (Rattus norvegicus)
REACT:R-CEL-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Caenorhabditis elegans)
RHEA:14183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2
REACT:R-HSA-9757445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST translocates from ER lumen to cytosol of GI cells (Homo sapiens)
RHEA:65572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-8941543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Bos taurus)
RHEA:40296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexadecanedioate => AMP + diphosphate + hexadecanedioyl-CoA
RHEA:70457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2 => (6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine
REACT:R-RNO-6800797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome activates CASP2 (Rattus norvegicus)
REACT:R-HSA-508451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B is phosphorylated (Homo sapiens)
RHEA:53250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:29885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-ornithine(in) + phosphate => ATP + H2O + L-ornithine(out)
REACT:R-DRE-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Danio rerio)
RHEA:64339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 malonyl-CoA + nicotinyl-CoA <=> 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-BTA-2130731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of COPII vesicle (Bos taurus)
GO:0003743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation initiation factor activity
REACT:R-RNO-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Rattus norvegicus)
REACT:R-DRE-141186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD oxidatively deaminates of 5HT (Danio rerio)
REACT:R-HSA-376119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Bnip-2 with Cdc42 (Homo sapiens)
REACT:R-XTR-909732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT2 (Xenopus tropicalis)
REACT:R-XTR-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Xenopus tropicalis)
RHEA:21684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-beta-alanopine + H2O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate
RHEA:21684	skos:prefLabel	"beta-alanopine dehydrogenase"
RHEA:21684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-alanopine dehydrogenase"
REACT:R-DDI-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Dictyostelium discoideum)
RHEA:16667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate => (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O
RHEA:12944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:54705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:45294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin H2 + A + H2O => 2-glyceryl-prostaglandin G2 + AH2
REACT:R-DDI-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Dictyostelium discoideum)
REACT:R-HSA-5694082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XK:KEL:Zn2+ cleaves EDN3 (Homo sapiens)
REACT:R-CFA-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Canis familiaris)
REACT:R-CFA-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Canis familiaris)
RHEA:47891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
RHEA:61768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside A + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP
REACT:R-SSC-6807118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)
REACT:R-SSC-877269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS-1 and SOCS-3 binds to p-JAK2 (Sus scrofa)
REACT:R-DRE-76416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Benzene is hydroxylated to phenol (Danio rerio)
RHEA:70120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
EC:3.4.21.93	skos:altLabel	"neuroendocrine convertase 1"
EC:3.4.21.93	skos:altLabel	"NEC 1"
EC:3.4.21.93	skos:prefLabel	"proprotein convertase 1"
EC:3.4.21.93	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"proprotein convertase 1"
EC:3.4.21.93	skos:altLabel	"PC1"
EC:3.4.21.93	skos:altLabel	"prohormone convertase I"
REACT:R-GGA-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Gallus gallus)
REACT:R-BTA-8940134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 binds FOLA (Bos taurus)
REACT:R-BTA-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Bos taurus)
REACT:R-XTR-9012761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI binds RHOA-GDI (Xenopus tropicalis)
REACT:R-GGA-2730842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K associates with phosphorylated GAB2 (Gallus gallus)
REACT:R-CFA-2309787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS2 (Canis familiaris)
RHEA:18578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine
RHEA:54275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate
REACT:R-DRE-418176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB2 binds MAPKs, SRC-1 (Danio rerio)
REACT:R-CFA-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
REACT:R-XTR-2530429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of soluble VTN:C5b-C9  (Xenopus tropicalis)
REACT:R-SCE-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Saccharomyces cerevisiae)
RHEA:38792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine
GO:0043212	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carbohydrate-exporting ATPase activity
GO:0043212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate-exporting ABC transporter activity
REACT:R-DRE-174438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate on the C-strand (Danio rerio)
REACT:R-BTA-8849085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RHOA:GTP (Bos taurus)
RHEA:28009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(alpha)-methyl-L-tryptophan + O2 <=> formaldehyde + H2O2 + L-tryptophan
REACT:R-CFA-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Canis familiaris)
RHEA:59010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + salicylate => H2O + O2 + salicylaldehyde
REACT:R-XTR-5654684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR4 (Xenopus tropicalis)
RHEA:19976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + spermine
REACT:R-DME-4546385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO2 (Drosophila melanogaster)
REACT:R-RNO-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Rattus norvegicus)
REACT:R-SSC-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Sus scrofa)
RHEA:25952	skos:prefLabel	"2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase"
RHEA:25952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate
RHEA:25952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase"
RHEA:25952	skos:altLabel	"ADH synthase"
REACT:R-MMU-5218905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Mus musculus)
REACT:R-CEL-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Caenorhabditis elegans)
RHEA:52509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-8858500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC10A binds Tn-MUC1 (Bos taurus)
REACT:R-RNO-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Rattus norvegicus)
REACT:R-BTA-77613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR2 homodimer to dsRNA duplex (Bos taurus)
RHEA:51623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + formate + H(+) <=> CO2 + dCTP + H2O
RHEA:53444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-391372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRH1,2 (Canis familiaris)
REACT:R-HSA-6802918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
REACT:R-BTA-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)
REACT:R-CFA-199839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate RSK (Canis familiaris)
REACT:R-HSA-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Homo sapiens)
REACT:R-RNO-1358798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 binds neuregulin-activated ERBB3 (Rattus norvegicus)
RHEA:31092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dodecanoyl-CoA => 3-oxotetradecanoyl-CoA + CoA
RHEA:59715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraono-1,5-lactone + H2O <=> D-maltotetraonate + H(+)
REACT:R-SCE-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Saccharomyces cerevisiae)
REACT:R-SSC-9667952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 is deacetylated by SIRT2 (Sus scrofa)
REACT:R-DME-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Drosophila melanogaster)
REACT:R-SSC-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Sus scrofa)
RHEA:43235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isatin <=> H(+) + isatinate
RHEA:46767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Sus scrofa)
RHEA:54032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)
REACT:R-MMU-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Mus musculus)
REACT:R-SPO-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Schizosaccharomyces pombe)
RHEA:34672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
RHEA:57414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-tyrosine + NADPH => AMP + diphosphate + L-tyrosinal + NADP(+)
REACT:R-HSA-5637798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)
REACT:R-HSA-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)
REACT:R-HSA-2997616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Homo sapiens)
REACT:R-HSA-1470010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs (Homo sapiens)
REACT:R-PFA-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Plasmodium falciparum)
EC:1.3.1.39	skos:prefLabel	"enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)"
EC:1.3.1.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)"
EC:1.3.1.39	skos:altLabel	"acyl-ACP dehydrogenase"
EC:1.3.1.39	skos:altLabel	"enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific)"
RHEA:17315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-histidyl-tRNA(His) => ATP + L-histidine + tRNA(His)
RHEA:17607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate => ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine
REACT:R-CFA-8863471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR is bound by DAB2 and ARH (Canis familiaris)
RHEA:51200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine = H2O + N-retinylidene-N-retinylphosphatidylethanolamine
RHEA:40716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + hexadecanoyl-CoA => 1-hexadecanoylglycerone 3-phosphate + CoA
REACT:R-SSC-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Sus scrofa)
RHEA:64839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethanol + acetyl-CoA <=> CoA + phenethyl acetate
REACT:R-BTA-5685341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex stabilizes RAD51 filament (Bos taurus)
GO:0045499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemorepellent activity
GO:0045499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemorepellant activity
GO:0042018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-22 receptor activity
GO:0042018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-22R
GO:0042018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-22 receptor activity
REACT:R-SSC-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Sus scrofa)
RHEA:57860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-6-hydroxyferuloyl-CoA = CoA + scopoletin
REACT:R-HSA-5604929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C binds Protein S (Homo sapiens)
RHEA:59456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetradecan-1-ol = H(+) + NADPH + tetradecanal
REACT:R-XTR-159101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Xenopus tropicalis)
RHEA:16230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate
REACT:R-SSC-77345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Sus scrofa)
RHEA:28723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin(in) + H(+)(in) = (S)-allantoin(out) + H(+)(out)
REACT:R-SSC-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)
RHEA:72366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + hydrogencarbonate(in) <=> chloride(in) + hydrogencarbonate(out)
RHEA:24133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose => UDP-alpha-D-galactofuranose
REACT:R-DRE-5615637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Danio rerio)
REACT:R-DRE-2473186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FSTL3 binds Activin (Danio rerio)
REACT:R-HSA-8848873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARAP1 (Homo sapiens)
REACT:R-SPO-6807053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SC5D desaturates LTHSOL to 7-dehydroCHOL (Schizosaccharomyces pombe)
REACT:R-DDI-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Dictyostelium discoideum)
RHEA:29455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(in) = D-serine(out)
REACT:R-DME-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Drosophila melanogaster)
RHEA:68427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 <=> (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine:homocysteine methyltransferase activity
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylmethionine transmethylase activity
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylmethionine-homocysteine S-methyltransferase activity
GO:0008898	skos:prefLabel	"homocysteine S-methyltransferase"
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine-homocysteine transmethylase activity
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine homocysteine transmethylase activity
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:L-homocysteine methyltransferase activity
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylmethionine:homocysteine methyltransferase activity
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homocysteine methyltransferase activity
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-homocysteine S-methyltransferase activity
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homocysteine S-methyltransferase"
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + S-adenosyl-L-methionine = H(+) + L-methionine + S-adenosyl-L-homocysteine
GO:0008898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homocysteine transmethylase activity
RHEA:15722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H2O + NAD(+) => glyoxylate + H(+) + NADH + NH4(+)
GO:0004119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
REACT:R-SSC-420580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:PVRL3 trans heterodimer formation (Sus scrofa)
RHEA:47418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+) => an NDP-alpha-D-glucose + D-glucose
REACT:R-HSA-8952069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 deacetylates RUNX3 (Homo sapiens)
RHEA:15367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose
RHEA:37182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate <=> (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-8874202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the cytosol to the nucleus (Homo sapiens)
REACT:R-HSA-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Homo sapiens)
RHEA:48326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside Fuc-GD1b + GDP + H(+) => ganglioside GD1b + GDP-beta-L-fucose
RHEA:62376	skos:prefLabel	"2,4-didehydro-3-deoxy-L-rhamnonate hydrolase"
RHEA:62376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-didehydro-3-deoxy-L-rhamnonate hydrolase"
RHEA:62376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-didehydro-3-deoxy-L-rhamnonate + H2O = (S)-lactate + H(+) + pyruvate
RHEA:62376	skos:altLabel	"L-2,4-diketo-3-deoxyrhamnonate hydrolase"
REACT:R-DDI-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Dictyostelium discoideum)
RHEA:56096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal Gly-Gly + ATP + H(+) = [protein]-C-terminal Gly-Gly-AMP + diphosphate
RHEA:50581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]
REACT:R-RNO-265429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Rattus norvegicus)
RHEA:72018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine <=> 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A
REACT:R-BTA-435244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM1 is phosphorylated (Bos taurus)
REACT:R-HSA-159819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Homo sapiens)
REACT:R-HSA-3928632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITSN1 exchanges GTP for GDP on CDC42, activating it (Homo sapiens)
RHEA:39296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O
REACT:R-CFA-8865182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7A hydrolyses K11diUb (Canis familiaris)
RHEA:25664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene + diphosphate => (2E)-geranyl diphosphate
RHEA:25902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate => D-arabino-hex-3-ulose 6-phosphate
RHEA:40263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH
REACT:R-MMU-964759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alternative endo-mannosidase I route (Mus musculus)
REACT:R-HSA-8985929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Homo sapiens)
RHEA:66075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine
RHEA:27720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + phosphate => H2O + IMP
REACT:R-BTA-8852481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Bos taurus)
REACT:R-PFA-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Plasmodium falciparum)
REACT:R-MMU-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Mus musculus)
RHEA:17409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-coclaurine-N-methyltransferase"
RHEA:17409	skos:prefLabel	"(S)-coclaurine-N-methyltransferase"
RHEA:17409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-2161999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Rattus norvegicus)
REACT:R-GGA-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)
REACT:R-DRE-622415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 binds NEMO (Danio rerio)
REACT:R-RNO-6811423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Rattus norvegicus)
GO:0015113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite/nitrate porter activity
GO:0015113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite transmembrane transporter activity
GO:0102953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoglycin A gamma-glutamyl transpeptidase activity
RHEA:34514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP
REACT:R-PFA-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Plasmodium falciparum)
GO:0051670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inulase activity
GO:0051670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-inulinase activity
GO:0051670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoinulinase activity
GO:0051670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,1-beta-D-fructan fructanohydrolase activity
GO:0051670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inulinase activity
GO:0051670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exoinulinase activity
REACT:R-RNO-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Rattus norvegicus)
REACT:R-SSC-8865613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Sus scrofa)
REACT:R-CEL-5696872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates Ub-MOM proteins (Caenorhabditis elegans)
REACT:R-DRE-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Danio rerio)
RHEA:33525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) => ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O
REACT:R-GGA-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Gallus gallus)
RHEA:18114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + ATP => a ribonucleoside 5'-triphosphate + ADP
REACT:R-RNO-434836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk/Lck phosphorylate LAT (Rattus norvegicus)
REACT:R-BTA-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Bos taurus)
REACT:R-BTA-8944266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XI (Bos taurus)
RHEA:23829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH
REACT:R-HSA-5684081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds CDK2 and RBBP8 (Homo sapiens)
REACT:R-MMU-2160931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of tight junctions (Mus musculus)
REACT:R-SSC-9018895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Sus scrofa)
REACT:R-GGA-5205663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)
REACT:R-HSA-9027272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Homo sapiens)
REACT:R-HSA-210836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF6-dependent synthesis of NEUROG3 protein during morphogenesis (Homo sapiens)
RHEA:63816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)
RHEA:45296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingosylphosphocholine + H2O = a sphingoid base + H(+) + phosphocholine
REACT:R-MMU-432110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Mus musculus)
RHEA:34542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + tellurite <=> methanetellurite + S-adenosyl-L-homocysteine
REACT:R-HSA-6807206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 and OTUD3 deubiquitinate PTEN (Homo sapiens)
REACT:R-DRE-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Danio rerio)
RHEA:23307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atropine + H2O <=> H(+) + tropate + tropine
RHEA:29018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(out) + sn-glycerol 3-phosphate(in) <=> phosphate(in) + sn-glycerol 3-phosphate(out)
RHEA:47361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoate ester + H2O => an aliphatic alcohol + decanoate + H(+)
RHEA:41090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-CFA-191830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP nuclear import and release (Canis familiaris)
REACT:R-SSC-5661116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me3K5-histone H3 (Sus scrofa)
GO:0033755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphur oxygenase/reductase activity
GO:0033755	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sulfur oxygenase activity
GO:0033755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur oxygenase/reductase activity
GO:0033755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SOR
GO:0033755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity
RHEA:52274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gramine + H(+) + S-adenosyl-L-homocysteine => (1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine
REACT:R-HSA-8854222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D3 associates with RAB5 (Homo sapiens)
RHEA:72715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoate + ATP + H(+) = (R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate
REACT:R-RNO-3928612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KALRN exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
REACT:R-CFA-5138459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A:FZD4 is endocytosed (Canis familiaris)
GO:0047194	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity
GO:0047194	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity
GO:0047194	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity
GO:0047194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoleacetylglucose-inositol O-acyltransferase activity
REACT:R-XTR-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Xenopus tropicalis)
RHEA:22798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-hamamelose 2'-phosphate + H(+) => ATP + D-hamamelose
REACT:R-XTR-5668714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX1 complex (Xenopus tropicalis)
RHEA:40596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanedioyl-CoA + H2O => CoA + dodecanedioate + H(+)
REACT:R-DRE-173705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b binds C6 (Danio rerio)
RHEA:51548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-tetrahydropapaverine + S-adenosyl-L-methionine = (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine
RHEA:44515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine
RHEA:25064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)
RHEA:14606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + GDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + GDP + H(+)
REACT:R-HSA-5617855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXC4 mRNA is translated (Homo sapiens)
REACT:R-DRE-3247493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO1 (Danio rerio)
REACT:R-DDI-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Dictyostelium discoideum)
RHEA:19931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose
REACT:R-DME-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Drosophila melanogaster)
REACT:R-MMU-1169394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of IRF3 (Mus musculus)
RHEA:39258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)
REACT:R-MMU-210289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-DAP12 (Mus musculus)
RHEA:53592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycerol 3-phosphate + H2O = 1-tetradecanoyl-sn-glycerol + phosphate
RHEA:14864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + NADP(+) <=> H(+) + NADPH + orotate
GO:0022889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine(in) = L-serine(out)
GO:0022889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine transmembrane transporter activity
REACT:R-DME-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Drosophila melanogaster)
RHEA:66150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetyl-CoA
RHEA:49949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2
REACT:R-DRE-9619355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the cytosol (Danio rerio)
REACT:R-HSA-158893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Homo sapiens)
REACT:R-GGA-419462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)
GO:0004375	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine-cleavage complex
GO:0004375	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P-protein
GO:0004375	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)
GO:0004375	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine-cleavage complex P-protein activity
GO:0004375	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine decarboxylase activity
GO:0004375	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycine cleavage system P-protein activity
GO:0004375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine dehydrogenase (decarboxylating) activity
GO:0004375	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein P1
GO:0004375	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
RHEA:16487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate
REACT:R-DRE-8943959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP9 cleave SCUBE3 (Danio rerio)
REACT:R-BTA-5432852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR4:LY96 (Bos taurus)
REACT:R-CEL-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
REACT:R-HSA-873921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of STAT1 to p-IFNGR1 (Homo sapiens)
RHEA:43090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine => 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine
RHEA:51517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + S-adenosyl-L-methionine => (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Rattus norvegicus)
RHEA:22044	skos:altLabel	"proton pump"
RHEA:22044	skos:altLabel	"gastric H(+)/K(+) ATPase"
RHEA:22044	skos:altLabel	"potassium-transporting ATPase"
RHEA:22044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+)(in) + H2O + K(+)(out) = ADP + 2 H(+)(out) + K(+)(in) + phosphate
RHEA:22044	skos:prefLabel	"H(+)/K(+)-exchanging ATPase"
RHEA:22044	skos:altLabel	"H(+)/K(+)-ATPase"
RHEA:22044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"H(+)/K(+)-exchanging ATPase"
RHEA:39375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA = (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O
RHEA:44060	skos:prefLabel	"2-O-sulfo trehalose long-chain-acyltransferase"
RHEA:44060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA
RHEA:44060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-O-sulfo trehalose long-chain-acyltransferase"
RHEA:44060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA = 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA
REACT:R-DME-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Drosophila melanogaster)
REACT:R-SSC-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Sus scrofa)
RHEA:57155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[protein] + O2 <=> (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate
REACT:R-XTR-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Xenopus tropicalis)
REACT:R-RNO-2395965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)
REACT:R-DRE-8874718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA binds alpha-TOH (Danio rerio)
RHEA:71274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + thiamine(out) <=> H(+)(out) + thiamine(in)
RHEA:66003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)
GO:0047391	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity
GO:0047391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylglycerophosphoethanolamine phosphodiesterase activity
GO:0047391	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysophospholipase D activity
REACT:R-RNO-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Rattus norvegicus)
REACT:R-BTA-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Bos taurus)
RHEA:34694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactoyl-CoA <=> acryloyl-CoA + H2O
EC:3.4.23.49	skos:altLabel	"outer membrane protein 3B"
EC:3.4.23.49	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"omptin"
EC:3.4.23.49	skos:altLabel	"protease VII"
EC:3.4.23.49	skos:altLabel	"protease A"
EC:3.4.23.49	skos:prefLabel	"omptin"
REACT:R-GGA-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Gallus gallus)
RHEA:55027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Danio rerio)
RHEA:45177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:56488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-1112565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Mus musculus)
RHEA:25651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-isopiperitenone + H(+) + NADPH => (2R,5R)-isopulegone + NADP(+)
REACT:R-XTR-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Xenopus tropicalis)
REACT:R-CFA-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Canis familiaris)
RHEA:17022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + pyruvate => L-alanine + phosphonoacetaldehyde
RHEA:17739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroshikimate + H(+) + NADPH => NADP(+) + shikimate
REACT:R-DDI-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Dictyostelium discoideum)
RHEA:27615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate => di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate
REACT:R-SSC-5696482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTF1 binds LIFR:JAKs (Sus scrofa)
RHEA:51080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-139909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BMF to mitochondria (Gallus gallus)
RHEA:36145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + NADP(+) => (2E)-hexadecenoyl-CoA + H(+) + NADPH
REACT:R-HSA-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Homo sapiens)
REACT:R-XTR-5693751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH2 hydrolyses AEA to AA and ETA (Xenopus tropicalis)
RHEA:37638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:28943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(in) = glycine betaine(out)
REACT:R-SPO-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Schizosaccharomyces pombe)
GO:0106433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl-dGMP
GO:0106433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O6-methyl-dGTP hydrolase activity
RHEA:65570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O
RHEA:64214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + L-isoleucine => an N-(fatty acyl)-L-isoleucine + H2O
REACT:R-DDI-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Dictyostelium discoideum)
RHEA:44326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate + glycerol + H(+) => 1-butyrylglycerol + H2O
RHEA:63530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + 2 H2O => [thioredoxin]-dithiol + H2O2
REACT:R-RNO-9028730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FRS2 (Rattus norvegicus)
REACT:R-HSA-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Homo sapiens)
RHEA:15298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-BTA-444848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 1 binds relaxin 3 (Bos taurus)
GO:0030145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mn binding
GO:0030145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	manganese ion binding
GO:0030145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	manganese binding
RHEA:61200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
RHEA:63877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 => (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate
RHEA:38088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite = 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoadenylyl-sulphate reductase (thioredoxin) activity
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylylsulfate reductase activity
GO:0004604	skos:altLabel	"PAPS reductase, thioredoxin-dependent"
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS reductase, thioredoxin-dependent activity
GO:0004604	skos:altLabel	"3'-phosphoadenylylsulfate reductase"
GO:0004604	skos:altLabel	"PAdoPS reductase"
GO:0004604	skos:prefLabel	"phosphoadenylyl-sulfate reductase (thioredoxin)"
GO:0004604	skos:altLabel	"thioredoxin:3'-phospho-adenylylsulfate reductase"
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thioredoxin:3'-phospho-adenylylsulfate reductase activity
GO:0004604	skos:altLabel	"PAPS reductase"
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoadenosine-phosphosulfate reductase activity
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity
GO:0004604	skos:altLabel	"PAPS sulfotransferase"
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoadenylyl-sulfate reductase (thioredoxin) activity
GO:0004604	skos:altLabel	"thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase"
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoadenylyl-sulfate reductase (thioredoxin)"
GO:0004604	skos:altLabel	"phosphoadenosine-phosphosulfate reductase"
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS reductase activity
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS sulfotransferase activity
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAdoPS reductase activity
GO:0004604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)
REACT:R-XTR-9645428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 binds ADP-heptose (Xenopus tropicalis)
RHEA:15576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylserotonin + S-adenosyl-L-methionine <=> H(+) + melatonin + S-adenosyl-L-homocysteine
RHEA:71189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine(in) + L-tryptophan(out) => 3-hydroxy-L-kynurenine(out) + L-tryptophan(in)
RHEA:61369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferone sulfate(in) + ATP + H2O => 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate
RHEA:70046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone
GO:0150043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of extra-synaptic extracellular matrix
GO:0150043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extra-synaptic extracellular matrix structural constituent
GO:0150043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	synapse-associated extracellular matrix structural constituent
GO:0150043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of synapse-associated extracellular matrix
RHEA:45563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine <=> D-allo-isoleucine
RHEA:26215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aphidicolan-16beta-ol + diphosphate => 9alpha-copalyl diphosphate + H2O
REACT:R-HSA-167633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex (Homo sapiens)
REACT:R-DRE-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Danio rerio)
REACT:R-BTA-9645442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Bos taurus)
RHEA:12573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide + ADP + H(+) + phosphate
REACT:R-BTA-6800870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the FP subcomplex (Bos taurus)
REACT:R-SPO-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Schizosaccharomyces pombe)
RHEA:25163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ornithine <=> L-glutamate + L-glutamate 5-semialdehyde
REACT:R-HSA-1638803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
RHEA:24812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O
REACT:R-MMU-9735946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET small tyrosine kinase inhibitors bind MET (Mus musculus)
REACT:R-DME-110498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTOR is positively regulated by DRheb-GTP (Drosophila melanogaster)
REACT:R-HSA-3222072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAXX binds Ub-MDM2 and USP7 (Homo sapiens)
RHEA:70491	skos:altLabel	"GDP-fucose:polypeptide fucosyltransferase"
RHEA:70491	skos:prefLabel	"peptide-O-fucosyltransferase"
RHEA:70491	skos:altLabel	"GDP-fucose protein O-fucosyltransferase"
RHEA:70491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptide-O-fucosyltransferase"
RHEA:70491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-threonyl-[protein] = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)
RHEA:70491	skos:altLabel	"GDP-L-fucose:polypeptide fucosyltransferase"
RHEA:63533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin I + H2O => angiotensin-(1-9) + L-leucine
REACT:R-BTA-5690988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-incision of DNA by ERCC5 (XPG) in GG-NER (Bos taurus)
REACT:R-SSC-109822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Sus scrofa)
REACT:R-SCE-6786720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DECR2 reduces LCtE-CoA to t3enoyl-CoA (Saccharomyces cerevisiae)
RHEA:16117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate
RHEA:16117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetoacetate--CoA ligase"
RHEA:16117	skos:prefLabel	"acetoacetate--CoA ligase"
RHEA:16117	skos:altLabel	"acetoacetyl-CoA synthetase"
RHEA:44995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 2-methylbutanoyl-CoA <=> CoA + O-2-methylbutanoyl-(R)-carnitine
RHEA:22438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:56067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:38756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-9027042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPY4 ω-oxidises 14(S)-HDHA to MaR-L1 (Homo sapiens)
RHEA:54951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] <=> (2E,5Z)-dodecadienoyl-[ACP] + H2O
REACT:R-BTA-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Bos taurus)
REACT:R-MMU-879377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Mus musculus)
REACT:R-CFA-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)
REACT:R-XTR-400071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Xenopus tropicalis)
REACT:R-MMU-211190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of DFF45 (117) (Mus musculus)
REACT:R-DME-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Drosophila melanogaster)
RHEA:65892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = H2O + xanthurenate
RHEA:71517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine(in) => hypoxanthine(out)
REACT:R-CFA-77592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Intronless Pre-mRNA at 3'-end (Canis familiaris)
RHEA:32826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) <=> phosphate(out)
GO:0001540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyloid binding
GO:0001540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amyloid-beta binding
REACT:R-DME-176588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + PAPS => lithocholate sulfate + PAP (Drosophila melanogaster)
GO:0032018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanal reductase (NADP) activity
GO:0032018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanol:NADP oxidoreductase activity
GO:0032018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutyraldehyde reductase (NADP) activity
REACT:R-GGA-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Gallus gallus)
RHEA:50929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate
EC:1.1.1.40	skos:altLabel	"malic enzyme"
EC:1.1.1.40	skos:prefLabel	"malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))"
EC:1.1.1.40	skos:altLabel	"NADP-malic enzyme"
EC:1.1.1.40	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))"
EC:1.1.1.40	skos:altLabel	"pyruvic-malic carboxylase"
REACT:R-XTR-399952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIMK-1 by PAK (Xenopus tropicalis)
GO:0022843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated cation channel activity
GO:0022843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HV1-mediated H+ transfer (Homo sapiens)
GO:0022843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hv1 Mediated H+ Permeability (Homo sapiens)
RHEA:46871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
REACT:R-CFA-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)
RHEA:20585	skos:prefLabel	"secologanin synthase"
RHEA:20585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"secologanin synthase"
RHEA:20585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin
RHEA:62939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-acetyl-2'-deoxycytidine <=> 2'-deoxycytidine + acetate + H(+)
REACT:R-BTA-1234164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)
REACT:R-BTA-8961021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD binds with itself to form SFTPD 12mer (Bos taurus)
RHEA:68978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxoglycolithocholate + H(+) + NADPH => glycoursodeoxycholate + NADP(+)
REACT:R-RNO-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Rattus norvegicus)
REACT:R-GGA-377641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
RHEA:49711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocardicin G + S-adenosyl-L-methionine <=> H(+) + isonocardicin C + S-methyl-5'-thioadenosine
REACT:R-SSC-2730882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC-theta (Sus scrofa)
GO:0140670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent cohesin unloader activity
GO:0140670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cohesin unloader activity
GO:0140670	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent cohesin unloading activity
GO:0103085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5'-methylthio)pentylmalate synthase activity
RHEA:60745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin I
RHEA:53364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(47) in tRNA + NAD(+) = H(+) + NADH + uridine(47) in tRNA
RHEA:13970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + GTP => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP
RHEA:63590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin-4'-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate
RHEA:32206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-synephrine <=> (4-hydroxyphenyl)acetaldehyde + methylamine
RHEA:31711	skos:prefLabel	"beta-amyrin 11-oxidase"
RHEA:31711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-amyrin 11-oxidase"
RHEA:31711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:31711	skos:altLabel	"CYP88D6"
RHEA:37532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-SSC-5633051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFCAB7:IQCE binds EVC2:EVC (Sus scrofa)
RHEA:47242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein]
REACT:R-DME-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)
RHEA:41804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP(+)
RHEA:16384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NAD(+) <=> H(+) + L-xylulose + NADH
RHEA:42544	skos:prefLabel	"tRNA pseudouridine(32) synthase"
RHEA:42544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA pseudouridine(32) synthase"
RHEA:42544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(32) in tRNA = pseudouridine(32) in tRNA
RHEA:42544	skos:altLabel	"pseudouridine synthase RluA"
RHEA:58723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nicotine + NADPH + O2 <=> H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide
REACT:R-DDI-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Dictyostelium discoideum)
REACT:R-CFA-216723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Canis familiaris)
REACT:R-CEL-2028692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK4 (p-MST1) by caspase 3 (Caenorhabditis elegans)
REACT:R-DRE-5607753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD9 oligomerizes (Danio rerio)
RHEA:15326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + CoA
REACT:R-GGA-8940561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP7 cleaves OPTC (Gallus gallus)
REACT:R-SPO-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Schizosaccharomyces pombe)
REACT:R-RNO-5672972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
RHEA:25578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O2 + protoporphyrin IX => 3 O2 + protoporphyrinogen IX
RHEA:11501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O => 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate
RHEA:53029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + UDP-alpha-D-glucuronate => H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP
RHEA:46320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-chol-5-ene-24-oyl-CoA + A = 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2
REACT:R-GGA-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Gallus gallus)
REACT:R-MMU-8954398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer hydrolyses cardiolipin to PA and PG (Mus musculus)
REACT:R-GGA-388814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds CD28 (Gallus gallus)
GO:0102805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	codeine O-demethylase activity
RHEA:40442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-beta-D-quinovose <=> 6-deoxy-6-sulfo-D-fructose
RHEA:66810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A => 5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH
RHEA:36431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase
REACT:R-HSA-1237081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Homo sapiens)
RHEA:53450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol
REACT:R-RNO-2161651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGE2 is converted to PGF2a by CBR1 (Rattus norvegicus)
REACT:R-SPO-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Schizosaccharomyces pombe)
RHEA:56610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + tetrahydrosulfopterin => 5,10-methylenetetrahydrosulfopterin + glycine + H2O
RHEA:62416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + H2O = 4-hydroxybenzaldehyde + acetyl-CoA
REACT:R-DME-193073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Drosophila melanogaster)
REACT:R-MMU-391152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds PTK2B (Mus musculus)
REACT:R-DRE-9020282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Danio rerio)
REACT:R-GGA-375342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 36 mediated neuronal gap junction communication (Gallus gallus)
RHEA:10973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-hexose + H(+) + phosphoramidate => alpha-D-hexose 1-phosphate + NH4(+)
GO:0032267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA(Ile)-lysidine synthetase activity
GO:0032267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other carbon--nitrogen ligases"
GO:0032267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA(Ile)-2-lysyl-cytidine synthase activity
GO:0032267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA(Ile)-lysidine synthase activity
GO:0032267	skos:prefLabel	"Other carbon--nitrogen ligases"
REACT:R-RNO-5649723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Rattus norvegicus)
RHEA:42140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine
RHEA:40882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
RHEA:13924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CEL-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Caenorhabditis elegans)
REACT:R-RNO-110250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenoadenine by MPG glycosylase (Rattus norvegicus)
REACT:R-RNO-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Rattus norvegicus)
RHEA:19793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sarcosine dehydrogenase"
RHEA:19793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]
RHEA:19793	skos:prefLabel	"sarcosine dehydrogenase"
GO:0090566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity
REACT:R-GGA-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Gallus gallus)
REACT:R-GGA-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Gallus gallus)
REACT:R-MMU-199425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLPP dephosphorylates S473 in AKT (Mus musculus)
RHEA:14336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol
RHEA:64747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-3-(hexan-1-ol)-L-cysteine <=> 3-sulfanyl-1-hexanol + NH4(+) + pyruvate
REACT:R-SPO-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)
RHEA:62134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + dTDP => a 2'-deoxyribonucleoside 5'-phosphate + dTTP
RHEA:22126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ajmaline + H(+) => 17-O-acetylajmaline + H2O
REACT:R-CFA-9624112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK4 (Canis familiaris)
GO:0043961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate + succinyl-CoA = (R)-malyl-CoA + succinate
GO:0043961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinyl-CoA--D-citramalate CoA-transferase"
GO:0043961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA:(R)-citramalate CoA transferase activity
GO:0043961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA:R-citramalate CoA transferase
GO:0043961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-carnitine dehydratase/bile acid-inducible protein F
GO:0043961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA:(R)-citramalate CoA-transferase activity
GO:0043961	skos:prefLabel	"succinyl-CoA--D-citramalate CoA-transferase"
GO:0043961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalate + succinyl-CoA = (3R)-citramalyl-CoA + succinate
REACT:R-RNO-9027633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Rattus norvegicus)
REACT:R-SPO-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Schizosaccharomyces pombe)
RHEA:32043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+)
RHEA:32043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diadenosine hexaphosphate hydrolase (ATP-forming)"
RHEA:32043	skos:prefLabel	"diadenosine hexaphosphate hydrolase (ATP-forming)"
REACT:R-DME-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
RHEA:40111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H2O = butanoate + CoA + H(+)
REACT:R-CFA-2395873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)
RHEA:33557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + a fatty acid => an N-acyl-(4R)-4-hydroxysphinganine + H2O
RHEA:40468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)
RHEA:66086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-aspartate => L-kynurenine + oxaloacetate
RHEA:32683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethylfurfural + 2 H2O + 3 O2 = 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2
RHEA:32683	skos:prefLabel	"5-(hydroxymethyl)furfural oxidase"
RHEA:32683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-(hydroxymethyl)furfural oxidase"
REACT:R-CFA-193691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kB migrates to the nucleus and turns on transcription (Canis familiaris)
REACT:R-BTA-2187332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic CMs translocate to extracellular region (Bos taurus)
REACT:R-HSA-210788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF1B- and FGF10-dependent synthesis of PTF1A protein (Homo sapiens)
REACT:R-RNO-435244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM1 is phosphorylated (Rattus norvegicus)
REACT:R-MMU-9706345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Mus musculus)
REACT:R-PFA-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Plasmodium falciparum)
REACT:R-HSA-5662614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1E binds zinc (Homo sapiens)
REACT:R-CFA-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Canis familiaris)
RHEA:65530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexyl octanoate => hexan-1-ol + octanoyl-CoA
REACT:R-CEL-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Caenorhabditis elegans)
RHEA:53974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O
RHEA:52310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + NADPH => 2-hydroxyglutarate + NADP(+)
REACT:R-XTR-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Xenopus tropicalis)
REACT:R-BTA-5683588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 transfers ATG12 from ATG10 to ATG5 (Bos taurus)
RHEA:58968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthaldehyde + H2O + O2 = 1-naphthoate + H(+) + H2O2
RHEA:38125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol
GO:0140950	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H2A deubiquitination
GO:0140950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A deubiquitinase activity
RHEA:66989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanoate + ATP + CoA => 4-methylpentanoyl-CoA + AMP + diphosphate
RHEA:56666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+)
RHEA:54730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]
RHEA:49047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protoasukamycin <=> 4-hydroxyprotoasukamycin + H2O + NAD(+)
REACT:R-BTA-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Bos taurus)
REACT:R-BTA-5649801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Bos taurus)
REACT:R-RNO-5634750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Rattus norvegicus)
REACT:R-XTR-8944240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type III (Xenopus tropicalis)
REACT:R-HSA-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Homo sapiens)
REACT:R-GGA-8853737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Gallus gallus)
REACT:R-PFA-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Plasmodium falciparum)
RHEA:71464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P => Gly-L-Leu-L-Met-NH2 + substance P(1-8)
RHEA:70096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-methyl-tetronate + o-quinone methide => peniphenone D
REACT:R-SSC-109823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Sus scrofa)
RHEA:54168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-5672304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Bos taurus)
REACT:R-RNO-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)
REACT:R-DME-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Drosophila melanogaster)
REACT:R-BTA-168947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand binds to TLR10 (Bos taurus)
REACT:R-HSA-994038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF2 binds the promoters of Interferon alpha and beta (Homo sapiens)
REACT:R-DRE-4608854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 are recruited to the DVL2:PARD6A complex (Danio rerio)
REACT:R-SPO-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Schizosaccharomyces pombe)
REACT:R-MMU-77274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Mus musculus)
RHEA:26244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate <=> diphosphate + elisabethatriene
REACT:R-HSA-4717406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective DPM1 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)
RHEA:63157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-docosanoyl-taurine => docosanoate + taurine
RHEA:68123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a fatty acyl-CoA <=> a triacylglycerol + CoA
REACT:R-SSC-4420117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR2 autophosphorylates (Sus scrofa)
REACT:R-HSA-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
REACT:R-XTR-2855125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-1 binds to molecular patterns on the target cell surface (Xenopus tropicalis)
RHEA:26333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"molybdopterin synthase"
RHEA:26333	skos:altLabel	"MPT synthase"
RHEA:26333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin
RHEA:26333	skos:prefLabel	"molybdopterin synthase"
RHEA:44831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + decanoyl-CoA <=> CoA + O-decanoyl-(R)-carnitine
REACT:R-SCE-8869633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NR to yield NMN (Saccharomyces cerevisiae)
RHEA:26335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O
RHEA:22361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate => 5-oxo-D-proline + H2O
REACT:R-RNO-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Rattus norvegicus)
GO:0046922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fucosylation of Pre-NOTCH by POFUT1 (Homo sapiens)
GO:0046922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-fucose:polypeptide fucosyltransferase activity
GO:0046922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-fucose protein O-fucosyltransferase activity
GO:0046922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity
GO:0046922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-O-fucosyltransferase activity
GO:0046922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-fucose:polypeptide fucosyltransferase activity
GO:0008806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dienelactone hydrolase activity
GO:0008806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity
GO:0008806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxymethylene butenolide hydrolase activity
GO:0008806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maleylacetate enol-lactonase activity
GO:0008806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxymethylenebutenolidase activity
RHEA:17147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxydaidzein + 2 H(+) + NADPH => 2'-hydroxy-2,3-dihydrodaidzein + NADP(+)
REACT:R-DME-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Drosophila melanogaster)
RHEA:12947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2-ol + H(+) + sulfite => 2'-hydroxybiphenyl-2-sulfinate + H2O
REACT:R-BTA-389758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
RHEA:37072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine
RHEA:26174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + mycothiol => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA
REACT:R-HSA-173771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RTC (Reverse Transcription Complex) (Homo sapiens)
RHEA:68671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-192061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP46A1 24-hydroxylates CHOL (Homo sapiens)
REACT:R-MMU-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)
RHEA:40942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)
REACT:R-RNO-5693575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PKcs autophosphorylates (Rattus norvegicus)
REACT:R-DME-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)
RHEA:65338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin A + H2O + NADP(+) => chrodrimanin T + H(+) + NADPH + O2
RHEA:18850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] => a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-198440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Sus scrofa)
REACT:R-SSC-9696323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNRs bind CNR agonists (Sus scrofa)
REACT:R-HSA-8964278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (s):GTP binds SRC (Homo sapiens)
REACT:R-BTA-8848414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds CDKN1B (Bos taurus)
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2':3'-CNMP-3'-ase activity
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2',3'-cyclic nucleotide phosphohydrolase
GO:0004113	skos:altLabel	"cyclic-CMP phosphodiesterase"
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2':3'-cyclic nucleotide 3'-phosphodiesterase activity
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic 2',3'-nucleotide 3'-phosphodiesterase activity
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CNPase activity
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclic 2',3'-nucleotide phosphodiesterase
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2',3'-cyclic-nucleotide 3'-phosphodiesterase"
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2',3'-cyclic nucleoside monophosphate phosphodiesterase
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2',3'-cyclic nucleotide 3'-phosphohydrolase activity
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2',3'-cyclic AMP phosphodiesterase activity
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclic-CMP phosphodiesterase activity
GO:0004113	skos:prefLabel	"2',3'-cyclic-nucleotide 3'-phosphodiesterase"
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclic nucleotide 3'-phosphodiesterase activity
GO:0004113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
RHEA:34438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine <=> 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Bos taurus)
REACT:R-HSA-5605147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP1B1 does not 4-hydroxylate EST17b (Homo sapiens)
REACT:R-CEL-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Caenorhabditis elegans)
REACT:R-MMU-3108209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO1 (Mus musculus)
GO:0047397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichylphosphate-glucose phosphodiesterase activity
GO:0047397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity
GO:0047397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-phosphate-glucose phosphodiesterase activity
GO:0047397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol phosphoglucose phosphodiesterase activity
GO:0047397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Dol-P-Glc phosphodiesterase activity
EC:1.2.1.97	skos:altLabel	"SLA dehydrogenase"
EC:1.2.1.97	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-sulfolactaldehyde dehydrogenase"
EC:1.2.1.97	skos:prefLabel	"3-sulfolactaldehyde dehydrogenase"
RHEA:69093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + pentanal => 2 H(+) + NADH + pentanoate
REACT:R-MMU-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Mus musculus)
RHEA:63144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)-ethanolamine = (15Z)-tetracosenoate + ethanolamine
REACT:R-MMU-164840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP and Pi bind to ATPase (Mus musculus)
RHEA:29576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine(in) + Na(+)(in) => L-serine(out) + Na(+)(out)
RHEA:60756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone = cinerin I + CoA
GO:0050484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP-GMP specific 5'-nucleotidase activity
GO:0050484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP 5' nucleotidase activity
GO:0050484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP 5'-nucleotidase activity
REACT:R-DDI-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Dictyostelium discoideum)
GO:0008119	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPMT
GO:0008119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiopurine S-methyltransferase activity
GO:0008119	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:thiopurine S-methyltransferase activity
GO:0008119	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-thiopurine transmethylase activity
GO:0008119	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiopurine methyltransferase activity
GO:0008119	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mercaptopurine methyltransferase activity
RHEA:14986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
RHEA:47151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + caffeine + H2O <=> 1,3,7-trimethylurate + a ubiquinol
REACT:R-SCE-76052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIA To type 1 Promoter (Saccharomyces cerevisiae)
REACT:R-DDI-6805640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates KAT6A (Dictyostelium discoideum)
REACT:R-HSA-9700164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates FRS2 (Homo sapiens)
RHEA:43341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]
REACT:R-CFA-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Canis familiaris)
REACT:R-CFA-8854051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL18 ubiquitinates FBXL7 (Canis familiaris)
RHEA:51876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate = desmethylxanthohumol + diphosphate
RHEA:58765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)
RHEA:50450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + prostaglandin H3 => AH2 + prostaglandin G3
REACT:R-SCE-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Saccharomyces cerevisiae)
RHEA:42928	skos:prefLabel	"16S rRNA (cytosine(1402)-N(4))-methyltransferase"
RHEA:42928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (cytosine(1402)-N(4))-methyltransferase"
RHEA:42928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:11856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
RHEA:30730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + pyruvate <=> dADP + H(+) + phosphoenolpyruvate
REACT:R-CFA-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Canis familiaris)
GO:0032549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleoside binding
GO:0050453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin B(12r) reductase activity
GO:0050453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin B12r reductase activity
GO:0050453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2:cob(II)alamin oxidoreductase activity
GO:0050453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin B12 reduction
GO:0050453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin reductase activity
GO:0050453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:cob(II)alamin oxidoreductase activity
GO:0050453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	B12r reductase activity
GO:0050453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B12 reductase activity
GO:0050453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	B(12r) reductase activity
GO:0050453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cob(I)alamin:NAD+ oxidoreductase activity
REACT:R-CFA-5634221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 binds TRAF2 within TNFR1 signaling complex (Canis familiaris)
REACT:R-CFA-3322431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds TLE (Canis familiaris)
RHEA:16825	skos:altLabel	"uridine-cytidine kinase"
RHEA:16825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + uridine = ADP + H(+) + UMP
RHEA:16825	skos:prefLabel	"uridine/cytidine kinase"
RHEA:16825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uridine/cytidine kinase"
REACT:R-MMU-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Mus musculus)
RHEA:30439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase"
RHEA:30439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)
RHEA:30439	skos:prefLabel	"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase"
REACT:R-HSA-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Homo sapiens)
REACT:R-DME-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Drosophila melanogaster)
RHEA:33338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctadecanoyl-sn-glycerol + phosphate
REACT:R-HSA-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Homo sapiens)
REACT:R-BTA-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Bos taurus)
RHEA:42326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-XTR-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Xenopus tropicalis)
REACT:R-HSA-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Homo sapiens)
REACT:R-HSA-9708557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 binds BACH1:MAFK (Homo sapiens)
RHEA:17456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-beta-D-ribosylamine + ATP + glycine <=> ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate
RHEA:44771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2
RHEA:14809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenol + S-adenosyl-L-methionine = anisole + H(+) + S-adenosyl-L-homocysteine
RHEA:14809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenol O-methyltransferase"
RHEA:14809	skos:prefLabel	"phenol O-methyltransferase"
REACT:R-MMU-76453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A6 (Mus musculus)
RHEA:67872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP
RHEA:30059	skos:altLabel	"DHODase"
RHEA:30059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroorotate oxidase (fumarate)"
RHEA:30059	skos:altLabel	"DHOdehase"
RHEA:30059	skos:altLabel	"DHOD"
RHEA:30059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + fumarate = orotate + succinate
RHEA:30059	skos:prefLabel	"dihydroorotate oxidase (fumarate)"
RHEA:30059	skos:altLabel	"dihydoorotic acid dehydrogenase"
RHEA:30059	skos:altLabel	"dihydroorotate dehydrogenase"
RHEA:30059	skos:altLabel	"dihydroorotate oxidase"
REACT:R-MMU-8854209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A binds JFC1 (Mus musculus)
RHEA:71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + phosphate(in) => 2 Na(+)(out) + phosphate(out)
REACT:R-CFA-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Canis familiaris)
REACT:R-MMU-5223305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL, inhibiting it (Mus musculus)
REACT:R-HSA-443831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3-zeta binds Raf1 (Homo sapiens)
REACT:R-MMU-4568848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Mus musculus)
REACT:R-BTA-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Bos taurus)
REACT:R-GGA-6804955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDM2 (Gallus gallus)
RHEA:43876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA = 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate
REACT:R-HSA-9009541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds to TFF1 gene promoter (Homo sapiens)
REACT:R-DME-444654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled bile acid receptor binds lithocholic acid (Drosophila melanogaster)
RHEA:53824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADH
REACT:R-DME-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Drosophila melanogaster)
RHEA:62254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(in) + Zn(2+)(in) => 2 hydrogencarbonate(out) + Zn(2+)(out)
RHEA:16156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic amine + H2O + O2 <=> an aldehyde + H2O2 + NH4(+)
REACT:R-HSA-6792871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)
REACT:R-HSA-8983063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Homo sapiens)
REACT:R-SPO-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Schizosaccharomyces pombe)
REACT:R-HSA-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Homo sapiens)
RHEA:47273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoanhydrobacterioruberin => bisanhydrobacterioruberin + H2O
RHEA:38992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)
RHEA:16271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH => aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+)
GO:0047837	skos:altLabel	"D-xylose-NADP dehydrogenase"
GO:0047837	skos:prefLabel	"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)"
GO:0047837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose 1-dehydrogenase (NADP+) activity
GO:0047837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose-NADP dehydrogenase activity
GO:0047837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
GO:0047837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose:NADP+ oxidoreductase activity
GO:0047837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)"
GO:0047837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylose:NADP+ 1-oxidoreductase activity
RHEA:48129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesyl phosphate + H(+) + phosphate
REACT:R-CEL-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Caenorhabditis elegans)
GO:2001083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucan binding
GO:0050550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)
GO:0050550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-(1S,5S)-pinene synthase activity
GO:0050550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-geraniolene synthase activity
GO:0050550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyldiphosphate diphosphate lyase (pinene forming)
GO:0050550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pinene synthase activity
REACT:R-XTR-379044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gs-activating GPCR acts as a GEF for Gs (Xenopus tropicalis)
REACT:R-RNO-8857692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA demethylases demethylate N6-methyladenosine RNA (Rattus norvegicus)
REACT:R-SCE-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Saccharomyces cerevisiae)
RHEA:27821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NAD(+) <=> 2-dehydro-L-idonate + H(+) + NADH
RHEA:14712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(5)-steroid <=> a 3-oxo-Delta(4)-steroid
RHEA:18213	skos:prefLabel	"glucose-1-phosphate cytidylyltransferase"
RHEA:18213	skos:altLabel	"CDP-glucose diphosphorylase"
RHEA:18213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + CTP + H(+) = CDP-D-glucose + diphosphate
RHEA:18213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-1-phosphate cytidylyltransferase"
RHEA:18213	skos:altLabel	"CDP-glucose pyrophosphorylase"
RHEA:42026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH => 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+)
GO:0036002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-mRNA binding
GO:0036002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-coding primary transcript binding
REACT:R-RNO-174439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Rattus norvegicus)
REACT:R-CEL-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Caenorhabditis elegans)
REACT:R-BTA-212222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 recruits DNA methyltransferases (Bos taurus)
REACT:R-GGA-9710254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME oligomerizes (Gallus gallus)
EC:1.3.1.2	skos:altLabel	"dihydrouracil dehydrogenase (NADP+)"
EC:1.3.1.2	skos:prefLabel	"dihydropyrimidine dehydrogenase (NADP(+))"
EC:1.3.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydropyrimidine dehydrogenase (NADP(+))"
EC:1.3.1.2	skos:altLabel	"dihydrothymine dehydrogenase"
RHEA:52339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + H(+) <=> a long-chain fatty acyl-AMP + diphosphate
REACT:R-RNO-8871227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA4 (Rattus norvegicus)
REACT:R-SPO-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Schizosaccharomyces pombe)
REACT:R-DRE-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Danio rerio)
RHEA:53241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:20672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
REACT:R-CFA-8855648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM3 binds LAR-RPTP (Canis familiaris)
REACT:R-DRE-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Danio rerio)
GO:0062105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotide in RNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine
GO:0062105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA 2'-O-methyltransferase activity
RHEA:40403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-HSA-6804741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 forms homo- or heterodimers (Homo sapiens)
RHEA:60018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sesquisabinene B => (2E,6E)-farnesyl diphosphate
RHEA:22874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2
REACT:R-RNO-9699578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 phosphorylates CDKN1B (Rattus norvegicus)
REACT:R-HSA-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Homo sapiens)
RHEA:14952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinoline-4-carboxylate <=> 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2
RHEA:16393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juvenile hormone II = H(+) + juvenile hormone II carboxylate + methanol
REACT:R-MMU-8875816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds activated MET receptor (Mus musculus)
RHEA:64473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine => (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine
GO:0106317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methane + NADH + O2 = H2O + methanol + NAD(+)
GO:0106317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methane monooxygenase NADH activity
REACT:R-MMU-9661625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FVIII is secreted (Mus musculus)
RHEA:35887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-MMU-5654569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS2 (Mus musculus)
REACT:R-GGA-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Gallus gallus)
RHEA:17096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol
RHEA:54986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + 2 e(-) + 2 H(+) => a ubiquinol
REACT:R-CEL-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Caenorhabditis elegans)
RHEA:47171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH
RHEA:62504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate
RHEA:62504	skos:prefLabel	"3-amino-5-hydroxybenzoate--[acyl-carrier protein] ligase"
RHEA:62504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-amino-5-hydroxybenzoate--[acyl-carrier protein] ligase"
REACT:R-MMU-74207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Mus musculus)
RHEA:68711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> diphosphate + linalool
RHEA:47050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroshikimate + a quinol => a quinone + shikimate
RHEA:51685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl phosphate + CTP => (2E,6E)-farnesyl diphosphate + CDP
REACT:R-HSA-416690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4A binds to PLXND1 (Homo sapiens)
RHEA:47657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-methionine sulfone => CoA + H(+) + N-acetyl-L-methionine sulfone
RHEA:40644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)
RHEA:45269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-hydroxyechinenone + AH2 + O2 => 4',4'-dihydroxyechinenone + A + H2O
REACT:R-DRE-5336184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37L binds prosaposin (Danio rerio)
REACT:R-HSA-5662904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD isomers transform to BT, BTCA, BZ, ODHBT (Homo sapiens)
REACT:R-DRE-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Danio rerio)
RHEA:43327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
REACT:R-DRE-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Danio rerio)
REACT:R-CFA-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Canis familiaris)
REACT:R-CFA-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Canis familiaris)
REACT:R-SSC-8950342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBI3:CANX binds IL27 (Sus scrofa)
REACT:R-HSA-9007220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1/2 binds the E2F1 gene promoter (Homo sapiens)
RHEA:71072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-cysteine(out) => L-arginine(out) + L-cysteine(in)
RHEA:33377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + NADP(+) => a 1-acylglycerone 3-phosphate + H(+) + NADPH
RHEA:50714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chlorotetracycline + FAD + H(+) + 2 H2O => chloride + FADH2 + O2 + tetracycline
RHEA:13155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxosuccinate + 2 H(+) + NADH => (R)-glycerate + CO2 + NAD(+)
EC:2.1.1.49	skos:altLabel	"nicotine N-methyltransferase"
EC:2.1.1.49	skos:prefLabel	"amine N-methyltransferase"
EC:2.1.1.49	skos:altLabel	"tryptamine N-methyltransferase"
EC:2.1.1.49	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amine N-methyltransferase"
EC:2.1.1.49	skos:altLabel	"arylamine N-methyltransferase"
REACT:R-DRE-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Danio rerio)
RHEA:70167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)
RHEA:41138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-DME-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Drosophila melanogaster)
REACT:R-RNO-6799777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind PPP1R13B or TP53BP2 (Rattus norvegicus)
REACT:R-MMU-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Mus musculus)
RHEA:65317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chrodrimanin H + O2 => chrodrimanin E + CO2 + H2O + succinate
REACT:R-CFA-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)
REACT:R-XTR-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)
GO:0001616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ghrelin receptor activity
GO:0001616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth hormone secretagogue receptor activity
REACT:R-DRE-165758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and inactivation of eEF2K by activated S6K1 (Danio rerio)
RHEA:32948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA
RHEA:66618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg(2+)(out) + 2 Na(+)(in) => Mg(2+)(in) + 2 Na(+)(out)
RHEA:33709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-threonine => ATP + L-threonine
REACT:R-MMU-5690042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)
REACT:R-HSA-1592236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)
GO:0003994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
GO:0003994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate(isocitrate) hydro-lyase activity
GO:0003994	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	citrate hydro-lyase activity
GO:0003994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aconitase activity
GO:0003994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-aconitase activity
GO:0003994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aconitate hydratase activity
RHEA:59444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A = 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2
RHEA:53819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-succinyl-L-serine <=> L-cysteine + succinate
RHEA:12743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDP + NH4(+) => ADP + H(+) + H2O
REACT:R-BTA-9753676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1,2 acetylate APAP-Cys to APAP-Mer (Bos taurus)
RHEA:62750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylbutanoate + H(+) + monacolin J => H2O + lovastatin
GO:0004589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-dihydroorotate:NAD+ oxidoreductase activity
GO:0004589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroorotate dehydrogenase (NADH) activity
GO:0004589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orotate reductase (NADH) activity
REACT:R-SSC-6808496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)
RHEA:52998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-deoxyhypusine + NAD(+) => [eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH
GO:0032136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C/A mispair binding
GO:0032136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A/C mispair binding
GO:0032136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytosine/adenine mispair binding
GO:0032136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine/cytosine mispair binding
REACT:R-RNO-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Rattus norvegicus)
GO:0033990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity
GO:0033990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyldiaminobutanoate dehydratase activity
GO:0033990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyldiaminobutyrate dehydratase activity
GO:0033990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ectoine synthase activity
GO:0033990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ectoine synthase activity
GO:0033990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	EctC
GO:0033990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity
RHEA:51435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-aminoethylphosphonate + acetyl-CoA <=> [(1S)-1-acetamidoethyl]phosphonate + CoA
REACT:R-SSC-2466106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BGN binds Collagen types I, VI, (IX) (Sus scrofa)
RHEA:34340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Sus scrofa)
RHEA:35285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-CoA => (9Z)-octadecenoyl-CoA
REACT:R-CEL-9707505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to CLEC1B dimer (Caenorhabditis elegans)
RHEA:32649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin A + H(+) + S-adenosyl-L-homocysteine => erythromycin C + S-adenosyl-L-methionine
REACT:R-HSA-9636658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esxA binds PGK1 (Homo sapiens)
REACT:R-RNO-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Rattus norvegicus)
REACT:R-DME-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Drosophila melanogaster)
RHEA:13150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H(+) + NADPH => AH2 + NADP(+)
REACT:R-GGA-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Gallus gallus)
REACT:R-HSA-480378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Goosecoid (GSC) in the primitive streak (Homo sapiens)
RHEA:13868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol <=> beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)
REACT:R-BTA-391375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Bos taurus)
REACT:R-DRE-8944261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIII (Danio rerio)
REACT:R-DRE-9009282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates RUNX2 (Danio rerio)
EC:3.4.21.80	skos:prefLabel	"streptogrisin A"
EC:3.4.21.80	skos:altLabel	"pronase enzyme A"
EC:3.4.21.80	skos:altLabel	"SGPA"
EC:3.4.21.80	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"streptogrisin A"
EC:3.4.21.80	skos:altLabel	"Streptomyces protease A"
RHEA:59596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynuramine + O2 = 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)
GO:0071667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA/DNA hybrid binding
GO:0071667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA/RNA hybrid binding
REACT:R-HSA-8866283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
REACT:R-RNO-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Rattus norvegicus)
REACT:R-HSA-173705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b binds C6 (Homo sapiens)
REACT:R-SSC-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Sus scrofa)
RHEA:56344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-hydroxyisoflavone + UDP-alpha-D-glucose = a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP
RHEA:52125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin = L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)
REACT:R-BTA-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Bos taurus)
RHEA:48753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + validamycin A => CO2 + H(+) + succinate + validamycin B
REACT:R-SSC-6810392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMEM55B translocates to the nucleus (Sus scrofa)
REACT:R-HSA-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Homo sapiens)
RHEA:36706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,5S)-5-carboxymethylproline + ATP <=> (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)
REACT:R-DME-8985343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SOX9 (Drosophila melanogaster)
REACT:R-MMU-997309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of STAT1 by SHP2 (Mus musculus)
RHEA:72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine
REACT:R-HSA-9666428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
REACT:R-MMU-416530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1:FFAR1 ligands activates Gq (Mus musculus)
REACT:R-GGA-351863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active caspase-8 to the mitochondrial membrane (Gallus gallus)
RHEA:24748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobut-2-enoate + methanethiol => L-methionine
GO:0005151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1, type II receptor binding
GO:0005151	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-1, type II receptor ligand
GO:0005151	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-1 type II
RHEA:52905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,17(3)-seco-F430-17(3)-acid + ATP => ADP + coenzyme F430 + phosphate
REACT:R-RNO-433104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACT co-transports trivalent citrate and a sodium ion (Rattus norvegicus)
REACT:R-CFA-5218806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN autophosphorylates (Canis familiaris)
RHEA:23354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + succinate semialdehyde => 2-oxoglutarate + 4-aminobutanoate
REACT:R-DRE-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Danio rerio)
RHEA:62507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate
REACT:R-SPO-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Schizosaccharomyces pombe)
RHEA:20572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine <=> L-ornithine + urea
REACT:R-SSC-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Sus scrofa)
REACT:R-BTA-549322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations out of hepatic cells (Bos taurus)
RHEA:71220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + nitrate(out) => 2 Na(+)(in) + nitrate(in)
RHEA:17552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Sus scrofa)
RHEA:57229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-GDP
RHEA:37078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
REACT:R-SSC-5696457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDH2 dehydrogenates 3HBA (Sus scrofa)
REACT:R-RNO-8950423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Rattus norvegicus)
REACT:R-RNO-727819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 phosphorylates MKK6 (Rattus norvegicus)
GO:0102948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin C-glucosyltransferase activity
REACT:R-DRE-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Danio rerio)
REACT:R-HSA-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Homo sapiens)
RHEA:54341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
REACT:R-DME-6807134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Drosophila melanogaster)
RHEA:55549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine
REACT:R-BTA-199910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates ATF1 (Bos taurus)
REACT:R-BTA-389762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PD-1 (Bos taurus)
REACT:R-DDI-9033509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5L (Dictyostelium discoideum)
REACT:R-BTA-5683888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMCD1 binds GATA6, sequestering it (Bos taurus)
REACT:R-GGA-6805426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD8 binds CASP9(1-416) (Gallus gallus)
REACT:R-BTA-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Bos taurus)
REACT:R-DRE-9718360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide agonists (Danio rerio)
REACT:R-DME-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Drosophila melanogaster)
RHEA:19822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH
RHEA:43827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate
RHEA:21256	skos:prefLabel	"3-phosphoshikimate 1-carboxyvinyltransferase"
RHEA:21256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-phosphoshikimate 1-carboxyvinyltransferase"
RHEA:21256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate
RHEA:21256	skos:altLabel	"3-enol-pyruvoylshikimate-5-phosphate synthase"
RHEA:21256	skos:altLabel	"5-enolpyruvylshikimate-3-phosphate synthase"
RHEA:21256	skos:altLabel	"EPSP synthase"
GO:0031517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	red light photoreceptor activity
REACT:R-DME-6805109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates TP53 (Drosophila melanogaster)
RHEA:15204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymellein + S-adenosyl-L-methionine <=> 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
REACT:R-BTA-9011983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Bos taurus)
REACT:R-MMU-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)
REACT:R-DRE-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Danio rerio)
RHEA:51147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 <=> (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate
REACT:R-RNO-392195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi activation by P2Y purinoceptor 12 (Rattus norvegicus)
RHEA:49351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dihydroxyspirilloxanthin <=> 2-oxospirilloxanthin + H2O
REACT:R-SSC-2465934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL translocates from Muller cells to cone photoreceptor cells (Sus scrofa)
RHEA:50283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate
REACT:R-HSA-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Homo sapiens)
REACT:R-HSA-6791323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates BCL2L14 gene expression (Homo sapiens)
RHEA:71505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out) => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in)
RHEA:50373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphingoid base 1-phosphate(in) => an N-acylsphingoid base 1-phosphate(out)
REACT:R-SSC-1564120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII degradation by MMP1,2,3 (Sus scrofa)
RHEA:12239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nicotinate <=> 6-hydroxynicotinate + H(+) + NADPH
REACT:R-RNO-6800870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the FP subcomplex (Rattus norvegicus)
REACT:R-DRE-9013004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the ER membrane (Danio rerio)
RHEA:32921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + H(+) + methanol => H2O + methyl (indol-3-yl)acetate
REACT:R-GGA-109699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
REACT:R-MMU-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Mus musculus)
GO:0003979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose 6-dehydrogenase activity
REACT:R-DRE-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Danio rerio)
REACT:R-HSA-114261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)
REACT:R-DME-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Drosophila melanogaster)
RHEA:48830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + H2O + NADP(+) => H(+) + NADPH + O2 + resorcinol
RHEA:29290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + L-aspartate(in) <=> 2 H(+)(out) + L-aspartate(out)
REACT:R-DRE-375342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 36 mediated neuronal gap junction communication (Danio rerio)
GO:0034479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylglycerol phospholipase C activity
RHEA:34842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 5 malonyl-CoA <=> 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O
REACT:R-MMU-173754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Properdin stabilizes C3b:Bb bound to cell surfaces (Mus musculus)
RHEA:12342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein]
REACT:R-GGA-2752115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds CD44 (Gallus gallus)
REACT:R-HSA-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Homo sapiens)
REACT:R-SSC-191972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol is 7alpha-hydroxylated (Sus scrofa)
RHEA:32853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol
REACT:R-XTR-158766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Xenopus tropicalis)
GO:0050503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity
GO:0050503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose 6-phosphate phosphorylase activity
GO:0140740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-riboxanase activity
RHEA:13945	skos:prefLabel	"mandelate racemase"
RHEA:13945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mandelate racemase"
RHEA:13945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-mandelate = (R)-mandelate
REACT:R-RNO-5632668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMO translocates to the cilium (Rattus norvegicus)
RHEA:61946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylene cholesteryl beta-D-glucoside + H(+) + UDP => 24-methylenecholesterol + UDP-alpha-D-glucose
REACT:R-HSA-8877421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)
REACT:R-SSC-2029271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
GO:0071890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHO3- ion binding binding
GO:0071890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bicarbonate binding
GO:0071890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate binding
RHEA:47365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dodecanoate ester + H2O => an aliphatic alcohol + dodecanoate + H(+)
REACT:R-CFA-176175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Stalling of DNA replication fork and RPA binding (Canis familiaris)
GO:0035870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyinosine triphosphate pyrophosphatase activity
GO:0035870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dITP pyrophosphatase activity
GO:0035870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine-5'-triphosphate pyrophosphohydrolase activity
GO:0035870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dITP diphosphatase activity
RHEA:65890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-kynurenine
REACT:R-CEL-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Caenorhabditis elegans)
RHEA:32080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-yl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate
REACT:R-SPO-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Schizosaccharomyces pombe)
RHEA:23564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 columbamine + O2 = 2 berberine + 2 H2O
RHEA:23564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"columbamine oxidase"
RHEA:23564	skos:prefLabel	"columbamine oxidase"
RHEA:23564	skos:altLabel	"berberine synthase"
REACT:R-CFA-4615839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO2,3 (Canis familiaris)
REACT:R-DRE-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Danio rerio)
REACT:R-GGA-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Gallus gallus)
REACT:R-SCE-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)
GO:0140759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-methyltransferase activity (H3-K56 specific)
GO:0140759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3K56 methyltransferase activity
GO:0140759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K56 methylase activity
GO:0140759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-K56 specific)
GO:0140759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K56 methyltransferase activity
RHEA:70786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-aspartate(in) + L-glutamate(out) <=> H(+)(in) + L-aspartate(out) + L-glutamate(in)
REACT:R-BTA-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Bos taurus)
GO:0034849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-naphthoate CoA-transferase activity
REACT:R-RNO-163809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)
RHEA:62178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-glucose + H2O
RHEA:19429	skos:altLabel	"ADRBK1"
RHEA:19429	skos:altLabel	"beta-adrenergic-receptor kinase (phosphorylating)"
RHEA:19429	skos:altLabel	"beta-receptor kinase"
RHEA:19429	skos:altLabel	"beta-ARK"
RHEA:19429	skos:altLabel	"beta-AR kinase"
RHEA:19429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[beta-adrenergic-receptor] kinase"
RHEA:19429	skos:altLabel	"beta-adrenoceptor kinase"
RHEA:19429	skos:altLabel	"beta-adrenergic receptor-specific kinase"
RHEA:19429	skos:altLabel	"adrenergic receptor kinase"
RHEA:19429	skos:altLabel	"BARK1"
RHEA:19429	skos:prefLabel	"[beta-adrenergic-receptor] kinase"
RHEA:19429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+)
RHEA:19429	skos:altLabel	"beta2ARK"
RHEA:19429	skos:altLabel	"beta-adrenergic-receptor kinase"
RHEA:46070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-nonenoyl-CoA => (3E)-nonenoyl-CoA
GO:0031801	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 4 metabotropic glutamate receptor ligand
GO:0031801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 4 metabotropic glutamate receptor binding
REACT:R-BTA-158468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates PARA to PARA-SO4 (Bos taurus)
RHEA:18759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + cylindrospermopsin + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2
REACT:R-MMU-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Mus musculus)
REACT:R-MMU-888614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO2 dioxygenates L-Trp to NFK (Mus musculus)
REACT:R-DRE-417890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y5 receptor can bind to LPA (Danio rerio)
REACT:R-HSA-163617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (s) activates adenylate cyclase (Homo sapiens)
RHEA:27311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthalene-1,2-diol + O2 => 2-hydroxychromene-2-carboxylate + H(+)
REACT:R-XTR-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Xenopus tropicalis)
REACT:R-XTR-2537665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin-1 and -2 bind fibronectin (Xenopus tropicalis)
REACT:R-XTR-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Xenopus tropicalis)
REACT:R-SSC-3229102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPKAPK3 phosphorylates BMI1 (Sus scrofa)
RHEA:37457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate
REACT:R-MMU-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Mus musculus)
REACT:R-RNO-8852362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds CDKN1A (Rattus norvegicus)
RHEA:33731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin
REACT:R-DRE-77304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Danio rerio)
REACT:R-RNO-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Rattus norvegicus)
RHEA:51155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a thiol + L-cysteinyl-[sulfatase] + O2 <=> 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide
REACT:R-XTR-3296309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR3 binds HCAR3 ligands (Xenopus tropicalis)
RHEA:45340	skos:prefLabel	"[Wnt protein] O-palmitoleoyl-L-serine hydrolase"
RHEA:45340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[Wnt protein] O-palmitoleoyl-L-serine hydrolase"
RHEA:45340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)
RHEA:45340	skos:altLabel	"Notum"
GO:0098641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadherin binding involved in cell-cell adhesion
GO:0036136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine-oxaloacetate transaminase activity
GO:0036136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine-oxaloacetate transaminase activity
GO:0031820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y11 nucleotide receptor binding
GO:0031820	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P2Y11 nucleotide receptor ligand
REACT:R-SSC-5618105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)
REACT:R-SSC-170087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Sus scrofa)
REACT:R-GGA-183055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to EGFR (Gallus gallus)
REACT:R-DRE-9701531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727 STAT3 is acetylated (Danio rerio)
REACT:R-DME-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Drosophila melanogaster)
REACT:R-HSA-2426162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the HMGCR promoter (Homo sapiens)
REACT:R-HSA-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Homo sapiens)
REACT:R-CEL-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Caenorhabditis elegans)
RHEA:34715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine + ATP = 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)
REACT:R-CFA-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Canis familiaris)
REACT:R-CEL-8866283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)
GO:0102048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-isoleucine synthetase activity
REACT:R-BTA-9701531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727 STAT3 is acetylated (Bos taurus)
REACT:R-RNO-8869694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds CD14 (Rattus norvegicus)
REACT:R-XTR-191654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-src associates with Cx43 in gap junctions (Xenopus tropicalis)
RHEA:44174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + tetradecanoate => H2O + NAD(+) + tetradecanal
RHEA:24497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-deacetylvindoline + acetyl-CoA => CoA + vindoline
REACT:R-XTR-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Xenopus tropicalis)
REACT:R-DME-162830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)
REACT:R-SSC-211988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Sus scrofa)
GO:0052926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
GO:0052926	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichylphosphomannose-dependent ALG9 mannosyltransferase activity
REACT:R-BTA-8849350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Bos taurus)
REACT:R-BTA-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Bos taurus)
REACT:R-HSA-212252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Homo sapiens)
RHEA:67027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:38569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O
RHEA:15395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	meso-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate
REACT:R-MMU-5685838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex binds D-loop structures (Mus musculus)
RHEA:39396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)
REACT:R-MMU-8963734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Mus musculus)
REACT:R-SSC-5665802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Sus scrofa)
RHEA:56586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propane-1,2-diol => 1,2-epoxypropane + H2O
REACT:R-SSC-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Sus scrofa)
REACT:R-HSA-8855111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds PCSK9 (Homo sapiens)
RHEA:56286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH => a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+)
RHEA:41771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) <=> CMP + ganglioside GT1a (d18:1(4E)) + H(+)
RHEA:20863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,6R)-isopiperitenol + NAD(+) <=> (6R)-isopiperitenone + H(+) + NADH
RHEA:69886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(out) + 2 Na(+)(out) <=> L-ascorbate(in) + 2 Na(+)(in)
REACT:R-DDI-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Dictyostelium discoideum)
REACT:R-GGA-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Gallus gallus)
REACT:R-CFA-5662660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopachrome is transformed to DHICA by DCT (Canis familiaris)
REACT:R-SSC-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Sus scrofa)
REACT:R-RNO-198813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO dimers reduce DeHA to AscH- (Rattus norvegicus)
REACT:R-SSC-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Sus scrofa)
REACT:R-RNO-9009936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEL cleaves cellular ssRNA (Rattus norvegicus)
RHEA:42084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH
REACT:R-PFA-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Plasmodium falciparum)
REACT:R-HSA-2066778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Homo sapiens)
REACT:R-CFA-2467811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of sister chromatids (Canis familiaris)
REACT:R-CFA-3928617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB2 binds KALRN (Canis familiaris)
RHEA:53229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Bos taurus)
GO:0047074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxycatechol 1,2-dioxygenase activity
REACT:R-HSA-879221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSTPIP1 binds Pyrin (Homo sapiens)
REACT:R-HSA-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)
RHEA:24084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:41838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexanoyl-[ACP] + malonyl-[ACP]
REACT:R-XTR-432712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Xenopus tropicalis)
REACT:R-HSA-2730844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)
RHEA:25347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr)
REACT:R-HSA-8877918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2:MAF complex binds the BGLAP gene promoter (Homo sapiens)
RHEA:51212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH
REACT:R-RNO-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)
REACT:R-SSC-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Sus scrofa)
REACT:R-CFA-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Canis familiaris)
RHEA:71596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + succinate(in) => 2-oxoglutarate(in) + succinate(out)
REACT:R-CFA-8853745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA3 (Canis familiaris)
REACT:R-DRE-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Danio rerio)
RHEA:51981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-N,N-dihydroxypolyhomomethionine + H(+) => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O
RHEA:46808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase"
RHEA:46808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine = [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine
RHEA:46808	skos:prefLabel	"[trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase"
REACT:R-BTA-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Bos taurus)
RHEA:51348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine = 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine
RHEA:71854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate(out) <=> glycocholate(in)
REACT:R-BTA-2090043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(7) (Bos taurus)
REACT:R-DRE-9678737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR1:TYK2 binds TYK2 inhibitors (Danio rerio)
REACT:R-BTA-416530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1:FFAR1 ligands activates Gq (Bos taurus)
GO:0034559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisphenol A hydroxylase B activity
GO:0035251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucosyltransferase activity
REACT:R-DRE-5159250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF7IP binds SETDB1 (Danio rerio)
RHEA:18942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) => a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH
GO:0016893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
GO:0016893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-endonuclease activity
GO:0016893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
GO:0016893	skos:prefLabel	"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"
GO:0016893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"
RHEA:72219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in)
REACT:R-HSA-8961982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
RHEA:39737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:36436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate(in) => a 1,2-diacyl-sn-glycero-3-phosphate(out)
REACT:R-CEL-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Caenorhabditis elegans)
REACT:R-BTA-9640254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Bos taurus)
REACT:R-MMU-202437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 (Mus musculus)
REACT:R-MMU-2581474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK1,4,7 phosphorylate MII to p-MII (Mus musculus)
GO:0102986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose synthase activity
RHEA:16561	skos:altLabel	"squalene--hopene cyclase"
RHEA:16561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"squalene--hopanol cyclase"
RHEA:16561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + squalene = hopan-22-ol
RHEA:16561	skos:prefLabel	"squalene--hopanol cyclase"
RHEA:42147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine
REACT:R-CFA-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Canis familiaris)
REACT:R-GGA-975593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Gallus gallus)
EC:2.4.1.19	skos:altLabel	"Bacillus macerans amylase"
EC:2.4.1.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclomaltodextrin glucanotransferase"
EC:2.4.1.19	skos:altLabel	"cyclodextrin glycosyltransferase"
EC:2.4.1.19	skos:altLabel	"cyclodextrin glucanotransferase"
EC:2.4.1.19	skos:prefLabel	"cyclomaltodextrin glucanotransferase"
GO:0051912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoB--CoM heterodisulfide reductase activity
GO:0051912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity
GO:0051912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	soluble heterodisulfide reductase activity
GO:0051912	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	heterodisulfide reductase activity
GO:0051912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoB-CoM heterodisulfide reductase activity
GO:0051912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B--coenzyme M heterodisulfide reductase activity
GO:0051912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme B:coenzyme M:methanophenazine oxidoreductase activity
RHEA:20733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + [thioredoxin]-disulfide => [protein]-disulfide + [thioredoxin]-dithiol
GO:0042802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein homopolymerization
GO:0042802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	identical protein binding
GO:0042802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoform-specific homophilic binding
RHEA:43906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol
RHEA:11009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate
GO:0008310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
GO:0008310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ssDNA-specific 3'-5' exodeoxyribonuclease activity
REACT:R-HSA-9679819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 binds amlexanox (Homo sapiens)
RHEA:19361	skos:prefLabel	"(2E,6E)-farnesyl diphosphate synthase"
RHEA:19361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2E,6E)-farnesyl diphosphate synthase"
RHEA:19361	skos:altLabel	"FPP synthetase"
RHEA:19361	skos:altLabel	"farnesyl-diphosphate synthase"
RHEA:19361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate
RHEA:19361	skos:altLabel	"geranyltranstransferase"
RHEA:19361	skos:altLabel	"farnesyl pyrophosphate synthetase"
REACT:R-MMU-8863804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)
RHEA:58318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol
REACT:R-HSA-388468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR1A,B (Homo sapiens)
REACT:R-DME-1889955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT dimers transfer GlcA to tetrasaccharide linker (Drosophila melanogaster)
RHEA:24031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-(trimethylamino)butanoate + O2 <=> carnitine + CO2 + succinate
REACT:R-RNO-9610750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Rattus norvegicus)
REACT:R-BTA-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Bos taurus)
REACT:R-MMU-140355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS1 (Mus musculus)
GO:0015540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenyl propionate:hydrogen ion symporter activity
GO:0015540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenyl propionate:proton symporter activity
GO:0015540	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyphenyl propionate porter activity
REACT:R-RNO-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Rattus norvegicus)
REACT:R-CFA-9661723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)
RHEA:42242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA
REACT:R-RNO-8943040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF polyubiquitinates monoubiquitinated PCNA (Rattus norvegicus)
REACT:R-XTR-8944225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVII (Xenopus tropicalis)
RHEA:33933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal => all-trans-zeaxanthin + O2
REACT:R-RNO-1482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by HADH (IM) (Rattus norvegicus)
RHEA:48843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
RHEA:62713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone C + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin I
RHEA:58121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[protein] => 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate
RHEA:30785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + 2 H(+) + NADH => D-glyceraldehyde + H2O + NAD(+)
REACT:R-MMU-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Mus musculus)
REACT:R-SSC-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Sus scrofa)
RHEA:51502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-D-muramate 6-phosphate => ATP + N-acetyl-D-muramate
RHEA:38304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate 6-phosphate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)
GO:0015494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic amino acid:proton symporter activity
GO:0015494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic amino acid:hydrogen symporter activity
GO:0052737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate dehydrogenase (quinone) activity
GO:0052737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate:ubiquinone oxidoreductase activity
GO:0052737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:ubiquinone-8-oxidoreductase activity
GO:0052737	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyruvate dehydrogenase activity
GO:0052737	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyruvic dehydrogenase activity
REACT:R-CFA-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Canis familiaris)
REACT:R-HSA-6801666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates CENPJ (Homo sapiens)
RHEA:35614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menadiol + 2 O2 <=> 2 H(+) + menadione + 2 superoxide
REACT:R-MMU-5686398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPIDR binds BLM:TOP3A:RMI1:RMI2 (Mus musculus)
RHEA:57252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP = glycolate + GTP + H(+)
GO:0102630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gossypetin 8-methyl ester 3'-O-methyltransferase activity
REACT:R-MMU-2250301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyrrole cross-links (Mus musculus)
RHEA:14006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L,L-cystathionine => 2-oxobutanoate + L-cysteine + NH4(+)
REACT:R-GGA-444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR5 binds CXCL13 (Gallus gallus)
REACT:R-RNO-170843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 phosphorylates TGFBR1 (Rattus norvegicus)
REACT:R-MMU-8952044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)
RHEA:70934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + dopamine(out) + 2 Na(+)(out) <=> chloride(in) + dopamine(in) + 2 Na(+)(in)
REACT:R-BTA-9687828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-GlcNAcylation of RIPK3 (TLR4 signaling) (Bos taurus)
RHEA:28668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydroxyacetone + NADH => (S)-propane-1,2-diol + NAD(+)
REACT:R-HSA-2033488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding (Homo sapiens)
REACT:R-MMU-9756156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes ATV to ATVL (Mus musculus)
RHEA:59417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + tryptamine => H2O2 + indole-3-acetaldehyde + NH4(+)
RHEA:14850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-amidino-L-aspartate => L-aspartate + urea
REACT:R-GGA-9762345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDN:ALB dissociates (Gallus gallus)
REACT:R-SSC-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Sus scrofa)
GO:0120023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	somatostatin binding
REACT:R-DRE-3134804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING ubiquitination by TRIM32 or TRIM56 (Danio rerio)
REACT:R-CEL-170072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Caenorhabditis elegans)
REACT:R-DDI-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Dictyostelium discoideum)
REACT:R-XTR-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Xenopus tropicalis)
RHEA:67435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine
REACT:R-CEL-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Caenorhabditis elegans)
REACT:R-GGA-9021050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 oligomer binds ESRs (Gallus gallus)
RHEA:67347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 7-O-beta-D-glucoside + malonyl-CoA <=> CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)
REACT:R-CEL-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Caenorhabditis elegans)
RHEA:44866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O
REACT:R-XTR-209859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decarboxylation of 5-hydroxytryptophan forms serotonin (Xenopus tropicalis)
RHEA:38601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide + nicotinate-adenine dinucleotide phosphate => NADP(+) + nicotinate
REACT:R-MMU-110351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of SMUG1 glycosylase by APEX1 at the AP site (Mus musculus)
REACT:R-CFA-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)
REACT:R-DME-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Drosophila melanogaster)
REACT:R-RNO-83586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)
REACT:R-MMU-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)
REACT:R-DME-3215448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Drosophila melanogaster)
REACT:R-RNO-76052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIA To type 1 Promoter (Rattus norvegicus)
RHEA:21463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoin <=> 2 benzaldehyde
RHEA:12958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acetyl ester + H2O => acetate + an aliphatic alcohol + H(+)
REACT:R-XTR-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Xenopus tropicalis)
RHEA:52152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-indolylmethyl desulfoglucosinolate + UDP
REACT:R-CFA-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Canis familiaris)
RHEA:32192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-428752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:Gq complex (Homo sapiens)
REACT:R-RNO-83650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FasL:Fas binds FADD (Rattus norvegicus)
RHEA:56405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)
RHEA:64404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in)
REACT:R-DRE-5661290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Danio rerio)
REACT:R-DRE-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Danio rerio)
REACT:R-HSA-381116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated IRE1 dimer binds ADP (Homo sapiens)
REACT:R-MMU-210294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-2 (Mus musculus)
REACT:R-RNO-5649658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves DHU from damaged DNA (Rattus norvegicus)
REACT:R-RNO-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Rattus norvegicus)
REACT:R-XTR-5362437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are bound by lectins (Xenopus tropicalis)
RHEA:51100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamylputrescine + H2O + O2 => 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)
RHEA:12199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-fructose 6-phosphate + phosphate <=> acetyl phosphate + D-erythrose 4-phosphate + H2O
REACT:R-XTR-141186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD oxidatively deaminates of 5HT (Xenopus tropicalis)
RHEA:14381	skos:prefLabel	"gamma-guanidinobutyraldehyde dehydrogenase"
RHEA:14381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-guanidinobutyraldehyde dehydrogenase"
RHEA:14381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanal + H2O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH
REACT:R-DRE-6781814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 deubiquitinates RNF123 (Danio rerio)
RHEA:31796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(E)-beta-caryophyllene + H2O => (+)-caryolan-1-ol
RHEA:36984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA
REACT:R-CEL-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:70731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)
RHEA:12451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate + H2O <=> (R)-pantoate + beta-alanine
REACT:R-SSC-6814165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates CSA to HTAU (Sus scrofa)
REACT:R-MMU-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Mus musculus)
RHEA:42533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(55) in tRNA => pseudouridine(55) in tRNA
RHEA:32586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocarvone + H(+) + NADPH + O2 <=> 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)
REACT:R-MMU-8933452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE dimer binds phosphorylated DENND1 proteins (Mus musculus)
REACT:R-GGA-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Gallus gallus)
REACT:R-BTA-8850945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates PTEN (Bos taurus)
RHEA:56392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)
RHEA:32281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + CO2 + 2 NH4(+) => allantoate + 2 H(+) + 2 H2O
GO:0102679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5alpha)-campestan-3-one hydroxylase activity
REACT:R-CEL-389897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Caenorhabditis elegans)
REACT:R-CFA-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Canis familiaris)
RHEA:67061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asnovolin I + S-adenosyl-L-methionine => asnovolin K + S-adenosyl-L-homocysteine
RHEA:56795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]
RHEA:39430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)
GO:0102213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	in-chain hydroxy fatty acyl-CoA synthetase activity
REACT:R-HSA-5617641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)
REACT:R-CEL-159358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A3,4 dimers sulfate DA to DAOS (Caenorhabditis elegans)
REACT:R-CFA-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Canis familiaris)
REACT:R-XTR-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Xenopus tropicalis)
RHEA:68302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-tetradecanoyl-L-seryl-[protein] => L-seryl-[protein] + tetradecanoyl-CoA
REACT:R-HSA-5632668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMO translocates to the cilium (Homo sapiens)
RHEA:24196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)
GO:0031723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR4 chemokine receptor binding
GO:0031723	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CXCR4 chemokine receptor ligand
GO:0031723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stromal cell-derived factor 1 receptor binding
REACT:R-HSA-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Homo sapiens)
REACT:R-RNO-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Rattus norvegicus)
REACT:R-HSA-2045911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
REACT:R-GGA-9623384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-agonists bind ADRA1A,B,D (Gallus gallus)
RHEA:40081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => docosanoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-378513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Xenopus tropicalis)
REACT:R-DDI-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Dictyostelium discoideum)
RHEA:47298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein] => dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:18616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxybenzoate + AH2 + O2 <=> 4-hydroxybenzoate + A + formaldehyde + H2O
RHEA:45787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + phenylpropanonitrile <=> 3-phenylpropanoate + NH4(+)
RHEA:70839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-histidine(out) + Na(+)(out) = L-arginine(out) + L-histidine(in) + Na(+)(in)
REACT:R-GGA-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Gallus gallus)
REACT:R-HSA-2396083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins bind galactosyl sulfatide and related sulfated glycolipids (Homo sapiens)
RHEA:38020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-decanoylglycerol => 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
GO:0031802	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 5 metabotropic glutamate receptor ligand
GO:0031802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 5 metabotropic glutamate receptor binding
RHEA:14525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + beta-cyclopiazonate = AH2 + alpha-cyclopiazonate
RHEA:14525	skos:prefLabel	"beta-cyclopiazonate dehydrogenase"
RHEA:14525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-cyclopiazonate dehydrogenase"
RHEA:14525	skos:altLabel	"beta-cyclopiazonate oxidocyclase"
RHEA:14525	skos:altLabel	"beta-cyclopiazonic oxidocyclase"
RHEA:65186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	berkeleyone B + CO2 + H2O + succinate => 2-oxoglutarate + O2 + preaustinoid A1
REACT:R-DRE-8950724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Danio rerio)
REACT:R-DME-2128994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Drosophila melanogaster)
REACT:R-GGA-417122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation and translocation of the telomeric chromosome end (Gallus gallus)
REACT:R-CFA-9794008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC binds CFLAR (Canis familiaris)
REACT:R-SCE-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Saccharomyces cerevisiae)
GO:0001517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-O-sulphotransferase activity
GO:0001517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-O-sulfotransferase activity
REACT:R-XTR-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Xenopus tropicalis)
REACT:R-XTR-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Xenopus tropicalis)
GO:0050198	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)
GO:0050198	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pine stilbene synthase activity
GO:0050198	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	stilbene synthase activity
GO:0050198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pinosylvin synthase"
GO:0050198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = (E)-pinosylvin + 4 CO2 + 4 CoA
GO:0050198	skos:altLabel	"stilbene synthase"
GO:0050198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pinosylvin synthase activity
GO:0050198	skos:prefLabel	"pinosylvin synthase"
REACT:R-PFA-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Plasmodium falciparum)
REACT:R-BTA-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Bos taurus)
REACT:R-CFA-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Canis familiaris)
REACT:R-SSC-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Sus scrofa)
REACT:R-DRE-70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine => urocanate + NH4+ (Danio rerio)
RHEA:14039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + H(+) + NADPH => 4,5beta-dihydrocortisone + NADP(+)
REACT:R-DRE-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Danio rerio)
RHEA:66843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-448661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)
REACT:R-XTR-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Xenopus tropicalis)
REACT:R-HSA-6803946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates PLAGL1 expression (Homo sapiens)
RHEA:10919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate <=> all-trans-phytoene + diphosphate
REACT:R-MMU-418850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 (Mus musculus)
GO:0000901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation repressor activity, non-nucleic acid binding
REACT:R-SSC-397891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:G12/13 (active) dissociate (Sus scrofa)
RHEA:15841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH
RHEA:15841	skos:altLabel	"G6PDH"
RHEA:15841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-6-phosphate dehydrogenase (NAD(+))"
RHEA:15841	skos:altLabel	"glucose-6-phosphate 1-dehydrogenase"
RHEA:15841	skos:prefLabel	"glucose-6-phosphate dehydrogenase [NAD(P)(+)]"
RHEA:15841	skos:prefLabel	"glucose-6-phosphate dehydrogenase (NAD(+))"
RHEA:15841	skos:altLabel	"Glc6PDH"
RHEA:15841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-6-phosphate dehydrogenase (NADP(+))"
RHEA:15841	skos:altLabel	"glucose-6-phosphate dehydrogenase"
RHEA:15841	skos:altLabel	"G6PD"
RHEA:15841	skos:altLabel	"GPD"
RHEA:15841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-6-phosphate dehydrogenase [NAD(P)(+)]"
RHEA:15841	skos:prefLabel	"glucose-6-phosphate dehydrogenase (NADP(+))"
RHEA:15841	skos:altLabel	"Glc6PD"
RHEA:15841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
REACT:R-RNO-5687758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP4C:PPP4R2 dephosphorylates RPA2 (Rattus norvegicus)
REACT:R-HSA-2682349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)
RHEA:39667	skos:altLabel	"F420-dependent secondary alcohol dehydrogenase"
RHEA:39667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:39667	skos:prefLabel	"secondary-alcohol dehydrogenase (coenzyme-F420)"
RHEA:39667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"secondary-alcohol dehydrogenase (coenzyme-F420)"
RHEA:39667	skos:altLabel	"F420-dependent alcohol dehydrogenase"
REACT:R-GGA-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Gallus gallus)
RHEA:33660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-tetracosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)
REACT:R-CFA-6783556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIFR:JAKs bind gp130:JAKs:CNTFR (Canis familiaris)
RHEA:23298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-mannosamine + pyruvate => aceneuramate
RHEA:21718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2
RHEA:16046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP
REACT:R-HSA-6785181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 bind LIPC dimer (Homo sapiens)
REACT:R-DRE-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Danio rerio)
REACT:R-HSA-9706328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS2 (Homo sapiens)
RHEA:49783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + glycine <=> CoA + H(+) + N-docosanoylglycine
EC:4.1.-.-	skos:prefLabel	"Carbon-carbon lyases"
EC:4.1.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carbon-carbon lyases"
REACT:R-RNO-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Rattus norvegicus)
GO:0140068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone crotonyltransferase activity
RHEA:46243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-381435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
RHEA:35318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + malonyl-CoA <=> 3-oxooctadecanoyl-CoA + CO2 + CoA
RHEA:60405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine
RHEA:26254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isopimara-7,15-dienol + NADPH + O2 => 2 H2O + isopimara-7,15-dienal + NADP(+)
REACT:R-CEL-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Caenorhabditis elegans)
REACT:R-MMU-176702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Processive Complex and Completed Telomere End (Mus musculus)
RHEA:33087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + chemical entity
RHEA:17573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylmacrocin + S-adenosyl-L-methionine = H(+) + macrocin + S-adenosyl-L-homocysteine
RHEA:17573	skos:prefLabel	"demethylmacrocin O-methyltransferase"
RHEA:17573	skos:altLabel	"DMOMT"
RHEA:17573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethylmacrocin O-methyltransferase"
RHEA:13474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan + NAD(+) => H(+) + indole-3-pyruvate + NADH + NH4(+)
REACT:R-BTA-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Bos taurus)
REACT:R-XTR-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
REACT:R-GGA-210285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homophilic interaction of PECAM-1 (Gallus gallus)
RHEA:12073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (S)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)
RHEA:45068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + an acyl-CoA = CoA + O-acyl-(R)-carnitine
RHEA:28791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + NAD(+) = H(+) + NADH + thymine
REACT:R-SPO-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)
RHEA:18127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + AH2 + NH4(+) => A + a D-alpha-amino acid + H2O
RHEA:63880	skos:altLabel	"thiocyanate dehydrogenase"
RHEA:63880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + thiocyanate = cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur
RHEA:63880	skos:prefLabel	"thiocyanate desulfurase"
RHEA:63880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiocyanate desulfurase"
REACT:R-SSC-165758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and inactivation of eEF2K by activated S6K1 (Sus scrofa)
REACT:R-SSC-2247513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1:ligand is endocytosed (Sus scrofa)
RHEA:36619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydocosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine
REACT:R-MMU-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Mus musculus)
RHEA:37069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine
RHEA:29428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) => (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)
REACT:R-GGA-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Gallus gallus)
GO:0003976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminyl phosphotransferase activity
GO:0003976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity
GO:0003976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0003976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0003976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminylphosphotransferase activity
GO:0003976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity
GO:0003976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity
GO:0003976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity
GO:0003976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity
RHEA:54332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-CFA-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Canis familiaris)
REACT:R-MMU-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Mus musculus)
REACT:R-RNO-428007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled histidine and di-peptide cotransport (Rattus norvegicus)
REACT:R-DME-390224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Drosophila melanogaster)
REACT:R-RNO-507719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62:MEKK3 binds to TRAF6 (Rattus norvegicus)
RHEA:11205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
REACT:R-GGA-5607728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Gallus gallus)
RHEA:45873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA
RHEA:27442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + xylitol => D-xylose + H(+) + NADH
REACT:R-HSA-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)
REACT:R-BTA-159001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)
RHEA:10346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA
REACT:R-CFA-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Canis familiaris)
RHEA:12768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate <=> acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DDI-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Dictyostelium discoideum)
REACT:R-CFA-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Canis familiaris)
REACT:R-HSA-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Homo sapiens)
GO:0004170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dUTP nucleotidohydrolase activity
GO:0004170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dUTPase activity
GO:0004170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desoxyuridine 5'-triphosphate nucleotidohydrolase activity
GO:0004170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyuridine-triphosphatase activity
GO:0004170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP pyrophosphatase activity
GO:0004170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP diphosphatase activity
GO:0004170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desoxyuridine 5'-triphosphatase activity
REACT:R-XTR-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Xenopus tropicalis)
RHEA:38940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioscin + 2 H2O => diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose
RHEA:33208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-glutamate + NADPH => ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate
REACT:R-RNO-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Rattus norvegicus)
REACT:R-DME-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Drosophila melanogaster)
GO:0043338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity
GO:0043338	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase
RHEA:10728	skos:prefLabel	"GDP-6-deoxy-D-talose 4-dehydrogenase"
RHEA:10728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH
RHEA:10728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-6-deoxy-D-talose 4-dehydrogenase"
REACT:R-CEL-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Caenorhabditis elegans)
RHEA:59681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaose + O2 => D-maltopentaono-1,5-lactone + H2O2
REACT:R-HSA-2272668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and KIR2DS5 (Homo sapiens)
REACT:R-HSA-204485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Basigin binds CyPA (Homo sapiens)
RHEA:62801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 7-demethylsiderin + NADPH + O2 => 2 H2O + NADP(+) + orlandin
GO:0004969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine receptor activity
REACT:R-RNO-5654643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
GO:0050479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceryl-ether monooxygenase activity
GO:0050479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceryl-ether cleaving enzyme activity
GO:0050479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceryl ether oxygenase activity
GO:0050479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-alkylglycerol monooxygenase activity
GO:0050479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity
GO:0050479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceryl etherase activity
GO:0050479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylglycerol monooxygenase activity
REACT:R-DDI-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Dictyostelium discoideum)
REACT:R-SSC-2028598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS1 (Sus scrofa)
RHEA:71134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-asparagine(out) + Na(+)(out) <=> H(+)(out) + L-asparagine(in) + Na(+)(in)
REACT:R-DRE-5362386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Hh (Danio rerio)
RHEA:64399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-sarcosine(out) + H(+)(out) <=> glycyl-sarcosine(in) + H(+)(in)
REACT:R-BTA-9702354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCA antibodies (Bos taurus)
REACT:R-CEL-6799695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX5,6 reduce H2O2 to H2O (Caenorhabditis elegans)
RHEA:65534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutyl hexanoate + CoA => 2-methylbutan-1-ol + hexanoyl-CoA
RHEA:66300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)
REACT:R-RNO-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Rattus norvegicus)
RHEA:48213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine
REACT:R-MMU-445699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Mus musculus)
RHEA:64119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine
RHEA:71889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide => GTP + NAD(+)
RHEA:37290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-leucine(out) <=> ADP + H(+) + L-alanyl-L-leucine(in) + phosphate
RHEA:26118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + epi-cedrol
GO:0004677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-dependent protein kinase activity
REACT:R-DDI-1855163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Dictyostelium discoideum)
RHEA:69741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylsuccinyl-CoA + succinate => phenylsuccinate + succinyl-CoA
GO:0050200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity
GO:0050200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity
GO:0050200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasmalogen synthase activity
GO:0050200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysoplasmenylcholine acyltransferase activity
GO:0050200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity
RHEA:10131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin <=> all-trans-neoxanthin
REACT:R-DRE-5685319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex formation (Danio rerio)
REACT:R-SPO-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Schizosaccharomyces pombe)
GO:0051752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PWD
GO:0051752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:phospho-alpha-glucan, water phosphotransferase activity
GO:0051752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OK1
GO:0051752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglucan, water dikinase activity
RHEA:72488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + phosphoenolpyruvate(in) => citrate(in) + phosphoenolpyruvate(out)
REACT:R-CEL-167433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta-gamma subunits rebind the alpha-GDP subunit (Caenorhabditis elegans)
RHEA:17808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-adenosyl-L-homocysteine <=> adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine
REACT:R-MMU-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
REACT:R-RNO-5625848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Rattus norvegicus)
REACT:R-DRE-6813626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEAP2 binds bacteria (Danio rerio)
RHEA:21958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + UDP + vitexin 2''-O-beta-D-glucoside => UDP-alpha-D-glucose + vitexin
RHEA:10142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin D2 => NADP(+) + prostaglandin F2alpha
RHEA:10819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside <=> L-fucose + methyl beta-D-galactoside
RHEA:44277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:14184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 <=> (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate
RHEA:17747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP => N-acetyl-D-glucosamine + UDP-alpha-D-galactose
RHEA:45770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alaninol + L-glutamate => gamma-L-glutamyl-L-alaninol + H2O
REACT:R-XTR-5654582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates SHC1 (Xenopus tropicalis)
RHEA:42659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthine methyl ester-[translation elongation factor 2] + H2O <=> diphthine-[translation elongation factor 2] + H(+) + methanol
RHEA:27742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + adenine
RHEA:30314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine
RHEA:50195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-PFA-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Plasmodium falciparum)
RHEA:35116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + H(+) + malonyl-CoA => (4-coumaroyl)acetyl-CoA + CO2 + CoA
RHEA:22337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + L-homocysteine => L-methionine + N,N-dimethylglycine
RHEA:44007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl fatty acid + ATP + CoA <=> a 3-methyl fatty acyl-CoA + AMP + diphosphate
REACT:R-CFA-1112727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serine phosphorylation of STATs (Canis familiaris)
GO:1990405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein antigen binding
RHEA:21367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(6-aminohexanoyl)-6-aminohexanoate <=> 2 6-aminohexanoate
RHEA:45748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA
REACT:R-RNO-5693620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop formation mediated by PALB2, BRCA2 and RAD51 (Rattus norvegicus)
RHEA:62511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
GO:1902387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide 1-phosphate binding
REACT:R-DME-561072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal uptake of organic cations (Drosophila melanogaster)
REACT:R-DRE-8944225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVII (Danio rerio)
RHEA:65870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,17beta-dihydroxyandrostan-3-one => Delta(1)-dihydrotestosterone + H2O
RHEA:13592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate <=> 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate
RHEA:61542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-140748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Homo sapiens)
RHEA:34768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + H2O => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)
GO:0050236	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal reductase activity
GO:0050236	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PL reductase activity
GO:0050236	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxine dehydrogenase activity
GO:0050236	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxine:NADP 4-oxidoreductase activity
GO:0050236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine:NADP 4-dehydrogenase activity
GO:0050236	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxin dehydrogenase activity
GO:0050236	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxol dehydrogenase activity
REACT:R-MMU-9686088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDMD (Mus musculus)
REACT:R-SSC-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Sus scrofa)
REACT:R-XTR-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Xenopus tropicalis)
REACT:R-SSC-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Sus scrofa)
GO:0043772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylphosphate glycerol-3-phosphate acyltransferase activity
GO:0043772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GO:0043772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-phosphate:glycerol-3-phosphate acyltransferase activity
GO:0043772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylphosphate:glycerol-3-phosphate acyltransferase activity
REACT:R-BTA-9700154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds SHC1 (Bos taurus)
REACT:R-HSA-177671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
GO:0047402	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity
GO:0047402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glucosylgalactosylhydroxylysine glucosidase activity
GO:0047402	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity
REACT:R-CEL-4085087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Caenorhabditis elegans)
GO:0086006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in cardiac muscle cell action potential
REACT:R-CFA-4420121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate PLCG1 (Canis familiaris)
RHEA:14327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daphnin + H(+) + UDP => 7,8-dihydroxycoumarin + UDP-alpha-D-glucose
RHEA:39898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetate + UDP-alpha-D-glucose <=> 7-deoxyloganate + H(+) + UDP
REACT:R-CEL-2161791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Caenorhabditis elegans)
REACT:R-DRE-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Danio rerio)
RHEA:30210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylamine + 2 oxidized [amicyanin] <=> formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]
RHEA:30497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Bos taurus)
REACT:R-SSC-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Sus scrofa)
RHEA:29492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => cis-muurola-4(14),5-diene + diphosphate
REACT:R-MMU-6804955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDM2 (Mus musculus)
RHEA:47010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite => [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide
RHEA:25077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O
REACT:R-HSA-6809015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)
REACT:R-XTR-2046222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Xenopus tropicalis)
RHEA:23678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
RHEA:68561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate + D-glyceraldehyde 3-phosphate + NAD(+) => 1-arsono-3-phospho-D-glycerate + H(+) + NADH
RHEA:12857	skos:prefLabel	"methylaspartate mutase"
RHEA:12857	skos:altLabel	"glutamic isomerase"
RHEA:12857	skos:altLabel	"Beta-methylaspartate-glutamate mutase"
RHEA:12857	skos:altLabel	"glutamic mutase"
RHEA:12857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylaspartate mutase"
RHEA:12857	skos:altLabel	"glutamate mutase"
RHEA:12857	skos:altLabel	"glutamate isomerase"
RHEA:12857	skos:altLabel	"methylaspartic acid mutase"
RHEA:12857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-methyl-L-aspartate = L-glutamate
RHEA:52216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"poly(ADP-ribose) glycohydrolase"
RHEA:52216	skos:prefLabel	"poly(ADP-ribose) glycohydrolase"
RHEA:52216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose
RHEA:36809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-triacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octacosanoyl-CoA
REACT:R-XTR-141351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAOX:FAD oxidises NASPN to SPM (Xenopus tropicalis)
REACT:R-HSA-169905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS is phosphorylated by active TrkA receptor (Homo sapiens)
RHEA:27437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O
RHEA:27437	skos:prefLabel	"glutathione amide-dependent peroxidase"
RHEA:27437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione amide-dependent peroxidase"
RHEA:36551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)
RHEA:67935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + desmosterol(in) + H2O <=> ADP + desmosterol(out) + H(+) + phosphate
RHEA:54750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-firefly luciferyl-CoA => ATP + CoA + firefly L-luciferin
REACT:R-HSA-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Homo sapiens)
RHEA:62286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+) => 2 ATP + L-proline + L-tryptophan + NADPH
REACT:R-GGA-419452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + ubiquinone => orotate + ubiquinol (Gallus gallus)
REACT:R-DRE-9034855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK3 (Danio rerio)
REACT:R-DME-8847875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF1:GTP binds Golgin TRIP11 (Drosophila melanogaster)
RHEA:11817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate => beta-D-fructose 6-phosphate
RHEA:44201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyloctadecanoate + ATP + CoA => 12-methyloctadecanoyl-CoA + AMP + diphosphate
GO:0031746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 cysteinyl leukotriene receptor binding
GO:0031746	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 cysteinyl leukotriene receptor ligand
REACT:R-BTA-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Bos taurus)
RHEA:27847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)
REACT:R-GGA-350318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at TNLD (429) (Gallus gallus)
RHEA:46195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:34084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA => a (3S)-3-hydroxyacyl-CoA
REACT:R-BTA-139895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAK protein (Bos taurus)
REACT:R-HSA-8983870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Homo sapiens)
RHEA:35784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neamine + UDP-alpha-D-kanosamine => H(+) + kanamycin B + UDP
REACT:R-BTA-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Bos taurus)
REACT:R-CFA-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Canis familiaris)
REACT:R-XTR-264678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Xenopus tropicalis)
REACT:R-GGA-5618085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Gallus gallus)
REACT:R-SPO-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Schizosaccharomyces pombe)
RHEA:31433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-beta-santalene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-DME-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Drosophila melanogaster)
RHEA:24522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH => H2O + L-saccharopine + NAD(+)
RHEA:59346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltobiono-1,5-lactone + H2O2 => D-maltose + O2
RHEA:51452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate = beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 = H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)
RHEA:64841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethanol + benzoyl-CoA => CoA + phenethyl benzoate
REACT:R-XTR-188979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Xenopus tropicalis)
REACT:R-DME-6814682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of early-endosome derived vesicles at the TGN (Drosophila melanogaster)
RHEA:22442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP => UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-DRE-561072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal uptake of organic cations (Danio rerio)
RHEA:53236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-2426259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Drosophila melanogaster)
RHEA:62324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2
REACT:R-XTR-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Xenopus tropicalis)
REACT:R-MMU-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Mus musculus)
REACT:R-RNO-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Rattus norvegicus)
REACT:R-MMU-6803761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Mus musculus)
GO:0102728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity
RHEA:31526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 2 H(+) + O2 <=> 3 CO2 + ethene + H2O
GO:0102244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal dehydrogenase activity
REACT:R-DME-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Drosophila melanogaster)
GO:0000340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA m7G cap binding
GO:0000340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA 7-methylguanosine cap binding
RHEA:50948	skos:altLabel	"activation-induced cytidine deaminase"
RHEA:50948	skos:altLabel	"activation-induced deaminase"
RHEA:50948	skos:prefLabel	"single-stranded DNA cytosine deaminase"
RHEA:50948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"single-stranded DNA cytosine deaminase"
RHEA:50948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in single-stranded DNA + NH4(+)
RHEA:61107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:26273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-3 + S-adenosyl-L-methionine = Co-precorrin-4 + S-adenosyl-L-homocysteine
REACT:R-DRE-8858252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDLBP binds HDL (Danio rerio)
REACT:R-MMU-2395784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent CMs transform into mature CMs (Mus musculus)
RHEA:44350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dapdiamide B + H(+) + phosphate => ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate
RHEA:30051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetate + H2O = fluoride + glycolate + H(+)
RHEA:48714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(3+) + 2 H2O => 2 Fe(2+) + 2 H(+) + H2O2
RHEA:14281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfite dehydrogenase (cytochrome)"
RHEA:14281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + sulfite = 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate
RHEA:14281	skos:prefLabel	"sulfite dehydrogenase (cytochrome)"
RHEA:14281	skos:altLabel	"sulfite dehydrogenase"
RHEA:18652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactonate <=> 2-dehydro-3-deoxy-D-galactonate + H2O
REACT:R-GGA-5661124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR4-HIST1H4 (Gallus gallus)
RHEA:15403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + UDP => a dolichyl phosphate + UDP-alpha-D-glucose
RHEA:15931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + N-(hydroxymethyl)urea + 2 NH4(+) => 2 H(+) + 2 H2O + methylenediurea
REACT:R-DRE-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)
RHEA:69733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + phenylacetyl-CoA => CoA + phenylacetyl-AMP
RHEA:62992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecamide = NH4(+) + tetradecanoate
REACT:R-XTR-3215295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates MDM2 (Xenopus tropicalis)
RHEA:71994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> (-)-astellatene + diphosphate
RHEA:57692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-HSA-8853734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Homo sapiens)
REACT:R-XTR-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Xenopus tropicalis)
RHEA:20780	skos:altLabel	"guanosine monophosphate kinase"
RHEA:20780	skos:altLabel	"deoxyguanylate kinase"
RHEA:20780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GMP = ADP + GDP
RHEA:20780	skos:altLabel	"GMP kinase"
RHEA:20780	skos:prefLabel	"guanylate kinase"
RHEA:20780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanylate kinase"
GO:0102710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-inositol-3-phosphate glycosyltransferase activity
REACT:R-CEL-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Caenorhabditis elegans)
GO:0046566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyphenylalanine dioxygenase activity
GO:0046566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOPA dioxygenase activity
REACT:R-CEL-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Caenorhabditis elegans)
REACT:R-SCE-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Saccharomyces cerevisiae)
REACT:R-HSA-3222116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L3MBTL1 binds TP53 monomethylated on K382 (Homo sapiens)
REACT:R-BTA-9693478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A agonists (Bos taurus)
GO:0000822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol hexakisphosphate binding
GO:0000822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	InsP6 binding
GO:0000822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 binding
REACT:R-DRE-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Danio rerio)
REACT:R-RNO-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)
RHEA:10145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 3'-phosphate + H2O => a ribonucleoside + phosphate
REACT:R-HSA-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Homo sapiens)
REACT:R-BTA-8939203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Bos taurus)
REACT:R-BTA-5695980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD10 dehydrogenates S-2MPDA-CoA (Bos taurus)
REACT:R-SSC-9027633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Sus scrofa)
REACT:R-HSA-180728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Ran-GTP with importin-beta (Homo sapiens)
RHEA:16814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-kynurenine => anthranilate + H(+) + L-alanine
RHEA:16407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH => benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+)
REACT:R-MMU-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Mus musculus)
RHEA:54772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate
REACT:R-RNO-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Rattus norvegicus)
REACT:R-RNO-9006850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor JAK phosphorylation (Rattus norvegicus)
GO:0033983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity
GO:0033983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DABA DC
GO:0033983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diaminobutyrate decarboxylase activity
GO:0033983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2,4-diaminobutyrate decarboxylase activity
GO:0033983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2,4-diaminobutanoate carboxy-lyase activity
RHEA:26447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + CoA + NADP(+) => H(+) + malonyl-CoA + NADPH
RHEA:39646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH <=> (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)
REACT:R-MMU-77299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Mus musculus)
RHEA:10342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-vetispiradiene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-BTA-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Bos taurus)
REACT:R-DME-1297444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of cAMP to HCN channels (Drosophila melanogaster)
REACT:R-HSA-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Homo sapiens)
REACT:R-HSA-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)
REACT:R-RNO-8857549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HBEGF-bound EGFR forms a heterodimer with GPNMB (Rattus norvegicus)
GO:0120297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone dopaminyltransferase activity
REACT:R-BTA-182990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty sequesters CBL away from active EGFR (Bos taurus)
REACT:R-BTA-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Bos taurus)
REACT:R-CEL-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Caenorhabditis elegans)
RHEA:64714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + propanal => 1-propanol + NADP(+)
REACT:R-GGA-389354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Vav1 (Gallus gallus)
REACT:R-MMU-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Mus musculus)
RHEA:13547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-8957265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades TP73 polyubiquitinated by ITCH (Sus scrofa)
REACT:R-XTR-109538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Xenopus tropicalis)
REACT:R-DRE-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Danio rerio)
GO:0001860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C3d receptor activity
REACT:R-SSC-350578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO1 interaction with ODC (Sus scrofa)
REACT:R-RNO-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Rattus norvegicus)
RHEA:34663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
RHEA:70923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline(out) + chloride(out) + Na(+)(out) = (R)-noradrenaline(in) + chloride(in) + Na(+)(in)
RHEA:45673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-BTA-4411402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NLK (Bos taurus)
RHEA:65263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	verruculide C epoxide <=> 3-hydroxypentacecilide A
RHEA:59216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + H(+) = CO2 + skatole
RHEA:59216	skos:prefLabel	"indoleacetate decarboxylase"
RHEA:59216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indoleacetate decarboxylase"
RHEA:59216	skos:altLabel	"IAD"
REACT:R-SSC-1169404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ISG15 from E1 to E2 (UBCH8) (Sus scrofa)
RHEA:44823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-13 + CO2 + diphosphate
GO:0061863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule plus end polymerase
REACT:R-MMU-213407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from SLP-76 (Mus musculus)
RHEA:17948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:19052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysine + GTP <=> (5R)-5-phosphooxy-L-lysine + GDP + H(+)
REACT:R-CEL-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Caenorhabditis elegans)
REACT:R-HSA-5625841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)
REACT:R-DME-171087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR [endosome membrane] => LDLR [plasma membrane] (Drosophila melanogaster)
REACT:R-RNO-8875374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds LRIG1 (Rattus norvegicus)
REACT:R-XTR-5251955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Xenopus tropicalis)
RHEA:55956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + AH2 + O2 = (12R)-hydroxy-(9Z)-octadecenoate + A + H2O
REACT:R-MMU-1980122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX binds NOTCH1 (Mus musculus)
REACT:R-SSC-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Sus scrofa)
REACT:R-CFA-6800490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates PIDD1 (Canis familiaris)
EC:2.5.1.137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-acyl-4-prenylphloroglucinol 6-prenyltransferase"
EC:2.5.1.137	skos:altLabel	"aromatic prenyltransferase"
EC:2.5.1.137	skos:prefLabel	"2-acyl-4-prenylphloroglucinol 6-prenyltransferase"
RHEA:44448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + CoA
REACT:R-HSA-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)
REACT:R-SSC-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Sus scrofa)
REACT:R-XTR-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Xenopus tropicalis)
RHEA:13289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP
RHEA:13289	skos:altLabel	"GlcNAc-1-P transferase"
RHEA:13289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase"
RHEA:13289	skos:altLabel	"N-acetylglucosamine-1-phosphate transferase"
RHEA:13289	skos:prefLabel	"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase"
REACT:R-RNO-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)
REACT:R-CFA-382055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb7 binds to the active PDGF receptor (Canis familiaris)
REACT:R-HSA-2127285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 stimulates transcription of FCER2 (CD23A) (Homo sapiens)
RHEA:42307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
REACT:R-SPO-9634169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 and NDC1 bind the Nup93 complex (Schizosaccharomyces pombe)
REACT:R-CFA-170846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 recruits TGFBR1 (Canis familiaris)
RHEA:63925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(4)-acetylcytidine => ADP + H(+) + N(4)-acetylcytidine 5'-phosphate
RHEA:33791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sucrose 6(F)-phosphate = beta-D-fructose + beta-D-glucose 6-phosphate
REACT:R-RNO-354149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
REACT:R-GGA-9015379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (compounds) binds IIa (Gallus gallus)
RHEA:69406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil(out) => uracil(in)
REACT:R-XTR-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Xenopus tropicalis)
RHEA:21255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2
RHEA:56137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a phenolic donor + H2O2 => 2 a phenolic radical donor + 2 H2O
REACT:R-DRE-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Danio rerio)
RHEA:33250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + putrescine <=> 1-pyrroline + H2O2 + NH4(+)
REACT:R-SSC-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Sus scrofa)
REACT:R-RNO-1236398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds NRGs or EGF-like ligands (Rattus norvegicus)
REACT:R-CEL-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)
RHEA:34407	skos:prefLabel	"2'-5' oligoadenylate synthase"
RHEA:34407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-5' oligoadenylate synthase"
RHEA:34407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate
REACT:R-RNO-193780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Rattus norvegicus)
GO:0046863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose-bisphosphate carboxylase activase activity
GO:0046863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity
GO:0046863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rubisco activator
GO:0046863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rubisco activase activity
GO:0046863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity
RHEA:35595	skos:prefLabel	"hydroxyquinol 1,2-dioxygenase"
RHEA:35595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyquinol 1,2-dioxygenase"
RHEA:35595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + O2 = 2 H(+) + maleylacetate
RHEA:18055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + diethylphosphate + 2 H(+) => H2O + paraoxon
RHEA:43590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NOR2 + H(+) + UDP => globoside NORint + UDP-alpha-D-galactose
RHEA:58261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => ADP-D-ribose + L-tyrosyl-[protein]
RHEA:41347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate
REACT:R-XTR-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Xenopus tropicalis)
RHEA:63487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]
REACT:R-CEL-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Caenorhabditis elegans)
RHEA:12595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate
REACT:R-MMU-8986083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates ROBO1 (Mus musculus)
GO:0102533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genkwanin 4'-O-methyltransferase activity
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NatC acetylates ARFFRP1 (Homo sapiens)
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide acetyltransferase activity
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nalpha-acetyltransferase activity
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(alpha)-acetyltransferase activity
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA:peptide alpha-N-acetyltransferase activity
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-endorphin acetyltransferase activity
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAT activity
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein N-terminal acetyltransferase activity
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide alpha-N-acetyltransferase activity
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amino-terminal amino acid-acetylating enzyme activity
GO:0004596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA:peptide nalpha-acetyltransferase activity
REACT:R-GGA-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)
REACT:R-HSA-9018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)
RHEA:10063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-tryptophan <=> CoA + H(+) + N-acetyl-D-tryptophan
RHEA:17127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-(2-aminobutanoyl)glycine => H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine
RHEA:18179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-CoA + H(+) + NADH => a 2,3-saturated acyl-CoA + NAD(+)
REACT:R-BTA-2029460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates LIMK1 (Bos taurus)
REACT:R-SSC-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Sus scrofa)
RHEA:17443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + L-glutamate => 2-oxoglutarate + L-cysteine
REACT:R-CEL-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Caenorhabditis elegans)
RHEA:46554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:0015573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucoside transmembrane transporter activity
GO:0015573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucoside permease activity
RHEA:47805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:63293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine
RHEA:54123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine h + O2 <=> coelenterazine h dioxetanone
REACT:R-CFA-9638090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Canis familiaris)
REACT:R-DRE-2028724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind YAP1 (Danio rerio)
REACT:R-DDI-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)
REACT:R-CEL-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
RHEA:44090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + heptanoyl-CoA => ATP + CoA + heptanoate
RHEA:15308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H2O + NAD(+) <=> glycine betaine + 2 H(+) + NADH
REACT:R-SCE-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Saccharomyces cerevisiae)
REACT:R-RNO-5686657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC1:XPF cleaves flaps generated by SSA (Rattus norvegicus)
REACT:R-HSA-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)
REACT:R-MMU-72095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internal Methylation of mRNA (Mus musculus)
RHEA:42345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + p-cumate => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)
REACT:R-SSC-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Sus scrofa)
REACT:R-GGA-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Gallus gallus)
REACT:R-DRE-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Danio rerio)
REACT:R-DRE-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Danio rerio)
REACT:R-SCE-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Saccharomyces cerevisiae)
REACT:R-XTR-74736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Xenopus tropicalis)
RHEA:49323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin <=> (5R,6S)-5,6-epoxi-capsanthin
REACT:R-DDI-141202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates TYR (Dictyostelium discoideum)
REACT:R-GGA-2672334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNN channels transport extracellular Na+ to cytosol (Gallus gallus)
REACT:R-XTR-9686930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is cleaved by CASP8 (Xenopus tropicalis)
REACT:R-DRE-6797961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHDH oxidises Cho to BETALD (Danio rerio)
REACT:R-RNO-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)
REACT:R-XTR-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Xenopus tropicalis)
REACT:R-DRE-8877192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds FOXP3 (Danio rerio)
REACT:R-HSA-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Homo sapiens)
REACT:R-DME-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)
REACT:R-CEL-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
REACT:R-RNO-1679589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal full-length TLR9 (Rattus norvegicus)
RHEA:24523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH
REACT:R-SSC-9708457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HM13 cleaves HMOX1 dimer (Sus scrofa)
REACT:R-BTA-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Bos taurus)
RHEA:21333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-glucosamine => CoA + H(+) + N-acetyl-D-glucosamine
REACT:R-CFA-443402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Canis familiaris)
RHEA:11428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2
RHEA:37943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O
REACT:R-SSC-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Sus scrofa)
REACT:R-DME-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Drosophila melanogaster)
REACT:R-XTR-977071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Xenopus tropicalis)
RHEA:11629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H(+) => an aldehyde + CO2
REACT:R-MMU-5691150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFR2 dimer binds 2xholoTF (Mus musculus)
REACT:R-CFA-5607722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK phosphorylates IKKA dimer (Canis familiaris)
REACT:R-BTA-216068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with Tenascin-C (Bos taurus)
REACT:R-XTR-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Xenopus tropicalis)
RHEA:37982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Drosophila melanogaster)
REACT:R-XTR-216076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Xenopus tropicalis)
RHEA:10886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + desmosterol => (24R,24(1)R)-fucosterol epoxide
RHEA:64064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-pseudoephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
REACT:R-RNO-211968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2W1 oxidises INDOL (Rattus norvegicus)
RHEA:69712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O => beta-D-glucose + N-hexadecanoylsphinganine
REACT:R-CFA-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Canis familiaris)
REACT:R-MMU-6785762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL13RA1 binds TYK2 (Mus musculus)
REACT:R-DME-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Drosophila melanogaster)
REACT:R-HSA-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Homo sapiens)
EC:2.7.1.214	skos:prefLabel	"C7-cyclitol 7-kinase"
EC:2.7.1.214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"C7-cyclitol 7-kinase"
REACT:R-DME-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Drosophila melanogaster)
REACT:R-GGA-2022368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-42) (Gallus gallus)
RHEA:28295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-(E)-beta-caryophyllene + diphosphate
REACT:R-MMU-353125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteosome degrades ODC holoenzyme complex (Mus musculus)
REACT:R-SSC-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Sus scrofa)
GO:0050552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-(4S)-limonene synthase activity
GO:0050552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(4S)-limonene synthase"
GO:0050552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]
GO:0050552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4S-(-)-limonene synthase activity
GO:0050552	skos:altLabel	"(-)-(4S)-limonene synthase"
GO:0050552	skos:prefLabel	"(4S)-limonene synthase"
GO:0050552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (4S)-limonene + diphosphate
GO:0050552	skos:altLabel	"4S-(-)-limonene synthase"
GO:0050552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene synthase activity
GO:0050552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]
GO:0050552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyldiphosphate diphosphate lyase (limonene forming)
REACT:R-CFA-5689317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the pre-incision complex in GG-NER (Canis familiaris)
REACT:R-DME-1236956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfment of particulate antigen into phagocytic vesicle (Drosophila melanogaster)
REACT:R-CFA-114697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Canis familiaris)
REACT:R-HSA-9035987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2 (Homo sapiens)
REACT:R-MMU-9033499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Mus musculus)
RHEA:30982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-lycopene <=> AH2 + all-trans-3,4-didehydrolycopene
REACT:R-GGA-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Gallus gallus)
RHEA:71541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + 2 nitrate(in) => H(+)(out) + 2 nitrate(out)
GO:0004692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP-dependent protein kinase activity
GO:0004692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity
GO:0004692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKG
GO:0004692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cGMP-dependent protein kinase ibeta activity
GO:0004692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKG 1beta
GO:0004692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKG II
GO:0004692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKG 1alpha
GO:0004692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3':5'-cyclic GMP-dependent protein kinase activity
GO:0004692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK23
GO:0004692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein phosphotransferase (cGMP-dependent) activity
REACT:R-XTR-6800380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAP-1 (Xenopus tropicalis)
REACT:R-CEL-193535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)
REACT:R-SSC-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Sus scrofa)
REACT:R-DRE-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)
REACT:R-MMU-170846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 recruits TGFBR1 (Mus musculus)
REACT:R-RNO-8987179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Rattus norvegicus)
REACT:R-SCE-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Saccharomyces cerevisiae)
REACT:R-SSC-5651657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)
REACT:R-SSC-5607747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MALT1 oligomers (Sus scrofa)
REACT:R-HSA-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Homo sapiens)
RHEA:39462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)
RHEA:45741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ectoine + O2 => 5-hydroxyectoine + CO2 + succinate
REACT:R-SCE-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Saccharomyces cerevisiae)
RHEA:24409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H(+) + H2O => inosine + NH4(+)
REACT:R-CEL-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Caenorhabditis elegans)
REACT:R-SSC-9647632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDME (Sus scrofa)
RHEA:39388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O
RHEA:35315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA
RHEA:31689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2
RHEA:43622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetaldehyde + CO2 + NADPH => L-serine + NADP(+)
RHEA:14654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 3',5'-cyclic phosphate + H2O => a nucleoside 5'-phosphate + H(+)
RHEA:15356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin + L-ascorbate <=> all-trans-antheraxanthin + H2O + L-dehydroascorbate
REACT:R-DRE-8941618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)
REACT:R-BTA-195690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Bos taurus)
REACT:R-CFA-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Canis familiaris)
GO:0004476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose-6-phosphate isomerase activity
GO:0004476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannose-6-phosphate aldose-ketose-isomerase activity
GO:0004476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannose phosphate isomerase activity
GO:0004476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphomannose isomerase activity
GO:0004476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannose-6-phosphate ketol-isomerase activity
GO:0004476	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphohexomutase activity
GO:0004476	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphohexoisomerase activity
GO:0004476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphomannoisomerase activity
RHEA:40162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose
RHEA:71271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + thiamine(out) = H(+)(out) + thiamine(in)
REACT:R-XTR-158744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Xenopus tropicalis)
REACT:R-CEL-193452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Caenorhabditis elegans)
REACT:R-CFA-9009817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acitretin binds to RAR:RXR (Canis familiaris)
REACT:R-HSA-203973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle budding (Homo sapiens)
REACT:R-DRE-114264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAX to the mitochondria (Danio rerio)
RHEA:35401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+) => 1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine
REACT:R-CFA-6799246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates TP53 (Canis familiaris)
REACT:R-CFA-450422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP recruits RNA degradation activities (Canis familiaris)
REACT:R-MMU-6805650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA2-NuRD complex deacetylates TP53 (Mus musculus)
REACT:R-HSA-380239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)
REACT:R-XTR-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)
REACT:R-DME-390120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated HPO dimer phosphorylates TH (Drosophila melanogaster)
REACT:R-RNO-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Rattus norvegicus)
REACT:R-GGA-444647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3a receptor binds anaphylatoxin C3a (Gallus gallus)
REACT:R-MMU-8985343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SOX9 (Mus musculus)
RHEA:60663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-benzoquinone + H(+) + NADH <=> hydroquinone + NAD(+)
RHEA:51566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DME-390886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH4 binds Hist (Drosophila melanogaster)
REACT:R-BTA-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Bos taurus)
REACT:R-PFA-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Plasmodium falciparum)
REACT:R-DME-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Drosophila melanogaster)
GO:0102216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltodextrin water dikinase
REACT:R-BTA-947531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Bos taurus)
GO:0102925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solanine UDP-galactose galactosyltransferase activity
REACT:R-GGA-5654426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
REACT:R-HSA-9684261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp4 is glycosylated (Homo sapiens)
RHEA:35134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-glutamate(out) <=> H(+)(in) + L-alanyl-L-glutamate(in)
REACT:R-XTR-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Xenopus tropicalis)
REACT:R-CFA-936991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Canis familiaris)
REACT:R-BTA-9762343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDL:ALB dissociates (Bos taurus)
GO:0018113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine racemase activity
RHEA:38523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)
REACT:R-HSA-996727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST recruits the BHC complex (Homo sapiens)
RHEA:12143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside + ATP <=> a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)
GO:0034896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-formiminopyruvate hydrolase activity
GO:0015387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium:proton symporter activity
GO:0015387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + K(+)(in) = H(+)(out) + K(+)(out)
GO:0015387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium:hydrogen symporter activity
GO:0061730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-rich strand telomeric DNA binding
RHEA:48736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9603445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 stimulates PI3K activity (Homo sapiens)
REACT:R-DRE-5362437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are bound by lectins (Danio rerio)
REACT:R-DDI-9603984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Dictyostelium discoideum)
RHEA:51712	skos:prefLabel	"D-tagatose 6-phosphate 4-epimerase"
RHEA:51712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-tagatose 6-phosphate 4-epimerase"
RHEA:51712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagatose 6-phosphate = keto-D-fructose 6-phosphate
RHEA:21716	skos:prefLabel	"mandelate 4-monooxygenase"
RHEA:21716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O
RHEA:21716	skos:altLabel	"mandelic acid 4-hydroxylase"
RHEA:21716	skos:altLabel	"L-mandelate 4-hydroxylase"
RHEA:21716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mandelate 4-monooxygenase"
REACT:R-BTA-428518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glypican-1 (GPC1) binds SLIT2 (Bos taurus)
REACT:R-DDI-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Dictyostelium discoideum)
RHEA:34893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenite(out) => selenite(in)
REACT:R-SSC-1855163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Sus scrofa)
RHEA:63386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
REACT:R-RNO-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Rattus norvegicus)
REACT:R-MMU-419843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCR (Mus musculus)
RHEA:34572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + diphosphate + NADP(+) => H(+) + NADPH + presqualene diphosphate
RHEA:18111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
REACT:R-MMU-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Mus musculus)
RHEA:45925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:22689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + H2O + O2 => H2O2 + NH4(+) + pyruvate
RHEA:68004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chloroethene = A + chloride + ethene + H(+)
REACT:R-XTR-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Xenopus tropicalis)
REACT:R-CFA-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Canis familiaris)
RHEA:28048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + propanoyl phosphate => phosphate + propanoyl-CoA
REACT:R-BTA-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Bos taurus)
REACT:R-XTR-4420117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR2 autophosphorylates (Xenopus tropicalis)
REACT:R-DRE-5661240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCXR tetramer reduces L-xylulose to xylitol (Danio rerio)
REACT:R-HSA-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Homo sapiens)
RHEA:32863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-DME-176298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of claspin (Drosophila melanogaster)
REACT:R-DME-451347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JNK by DSCAM (Drosophila melanogaster)
GO:0018844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytetrahydrofuran isomerase activity
GO:0070815	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysyl hydroxylase activity
GO:0070815	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysine hydroxylase activity
GO:0070815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity
GO:0070815	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysine,2-oxoglutarate 5-dioxygenase activity
GO:0070815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity
GO:0070815	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysine-2-oxoglutarate dioxygenase activity
GO:0070815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-lysine 5-dioxygenase activity
GO:0070815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein lysine hydroxylase activity
GO:0070815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-lysine 5-dioxygenase activity
REACT:R-DME-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)
GO:0005290	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histidine/arginine/lysine/ornithine porter activity
GO:0005290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine transmembrane transporter activity
GO:0005290	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-histidine transporter activity
REACT:R-HSA-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Homo sapiens)
REACT:R-CFA-8950183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B binds IL23A (Canis familiaris)
REACT:R-RNO-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Rattus norvegicus)
REACT:R-XTR-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Xenopus tropicalis)
RHEA:31260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	but-3-ynal + H2O + NAD(+) => 3-butynoate + 2 H(+) + NADH
REACT:R-HSA-9754763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 M protein binds TUFM (Homo sapiens)
REACT:R-HSA-9665515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RX4,7 binds itself to form trimeric non-selective cation channels (Homo sapiens)
REACT:R-DDI-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Dictyostelium discoideum)
REACT:R-SSC-418845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of caspase-3 (Sus scrofa)
RHEA:48024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + H(+) + propanoate
RHEA:22970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H(+) + NADH => butanal + CoA + NAD(+)
GO:0062152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine
GO:0062152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA (cytidine-5-)-methyltransferase activity
GO:0062152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA (cytosine-5-)-methyltransferase activity
RHEA:23166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 7-O-beta-D-glucoside + H(+) + UDP => a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose
RHEA:20689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorogenate hydrolase"
RHEA:20689	skos:altLabel	"chlorogenase"
RHEA:20689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorogenate + H2O = (E)-caffeate + H(+) + L-quinate
RHEA:20689	skos:prefLabel	"chlorogenate hydrolase"
RHEA:14500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + pyridoxine <=> AH2 + isopyridoxal
REACT:R-CEL-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
REACT:R-BTA-354073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PTK2 at Y397 (Bos taurus)
REACT:R-BTA-5357780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Bos taurus)
REACT:R-GGA-9648114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 recruits NUDC to mitotic spindle (Gallus gallus)
REACT:R-DRE-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Danio rerio)
REACT:R-HSA-5624951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNPO1 binds KIF17 dimer (Homo sapiens)
REACT:R-BTA-9648114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 recruits NUDC to mitotic spindle (Bos taurus)
REACT:R-DRE-9634861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT2 (Danio rerio)
GO:0016594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoethanoic acid binding
GO:0016594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly binding
GO:0016594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine binding
GO:0016594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetic acid binding
REACT:R-RNO-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Rattus norvegicus)
REACT:R-HSA-9692150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOX9 binds the DHH gene (Homo sapiens)
REACT:R-HSA-377641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
REACT:R-BTA-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Bos taurus)
REACT:R-SSC-4224014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by ADAM10, ADAM15 (Sus scrofa)
REACT:R-HSA-419843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCR (Homo sapiens)
RHEA:37373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O
REACT:R-DRE-374922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenalin synaptic vesicle docking and priming (Danio rerio)
RHEA:62831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-DRE-110350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of TDG glycosylase by APEX1 at the AP site (Danio rerio)
REACT:R-XTR-8944250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXV (Xenopus tropicalis)
REACT:R-MMU-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Mus musculus)
RHEA:54413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-5beta-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH
GO:1990119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent RNA helicase inhibitor activity
GO:1990119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA helicase inhibitor activity
EC:2.10.1.-	skos:prefLabel	"Molybdenumtransferases or tungstentransferases with sulfide groups as acceptors"
EC:2.10.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Molybdenumtransferases or tungstentransferases with sulfide groups as acceptors"
RHEA:37530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:62147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + dGTP <=> 2 dGDP
RHEA:41759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-PFA-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Plasmodium falciparum)
REACT:R-CFA-975594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLB1 hydrolyses RPALM to atROL (Canis familiaris)
RHEA:53091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Bos taurus)
RHEA:57164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 = (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate
REACT:R-HSA-8874191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L2 translocates from the cytosol to the nucleus (Homo sapiens)
REACT:R-HSA-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)
RHEA:29786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-cysteine(in) <=> ADP + H(+) + L-cysteine(out) + phosphate
REACT:R-BTA-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Bos taurus)
GO:0004495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mevaldate reductase activity
RHEA:70497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(in) + 2 Na(+)(in) => D-glucose(out) + 2 Na(+)(out)
RHEA:17888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde <=> acetylene + H2O
REACT:R-DDI-9014627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDS dimers:PXLP dehydrate L-Thr to 2AA (Dictyostelium discoideum)
RHEA:57004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + streptothricin D = CoA + H(+) + N(beta)-acetylstreptothricin D
RHEA:44589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol
GO:0050455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	columbamine:oxygen oxidoreductase (cyclizing)
GO:0050455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	berberine synthase activity
GO:0050455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	columbamine oxidase activity
GO:0016841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Ammonia-lyases"
GO:0016841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammonia-lyase activity
GO:0016841	skos:prefLabel	"Ammonia-lyases"
RHEA:60744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin I
REACT:R-SSC-71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)
REACT:R-XTR-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Xenopus tropicalis)
RHEA:71911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in)
RHEA:27364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + S-adenosyl-L-methionine <=> chloromethane + S-adenosyl-L-homocysteine
REACT:R-BTA-187688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)
REACT:R-DME-193455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)
REACT:R-DME-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Drosophila melanogaster)
REACT:R-MMU-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Mus musculus)
REACT:R-CEL-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Caenorhabditis elegans)
RHEA:38087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-GGA-9008822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1D dephosphorylates RUNX2 (Gallus gallus)
REACT:R-BTA-9706308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRB10 (Bos taurus)
REACT:R-DME-70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Drosophila melanogaster)
RHEA:45326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine => H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine
RHEA:53384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + NAD(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH
REACT:R-SCE-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)
REACT:R-GGA-6805785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates PHF20 (Gallus gallus)
REACT:R-HSA-9712088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK fusion proteins bind IRS (Homo sapiens)
REACT:R-CFA-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Canis familiaris)
RHEA:58245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] => ADP-D-ribose + L-lysyl-[protein]
REACT:R-CFA-5674132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Canis familiaris)
RHEA:68588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine = (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)
RHEA:68588	skos:prefLabel	"GDP-perosamine N-formyltransferase"
RHEA:68588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-perosamine N-formyltransferase"
RHEA:72838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cUAMP + H2O <=> H(+) + U[3'-5']pAp[3']
RHEA:11446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O
REACT:R-XTR-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Xenopus tropicalis)
REACT:R-CEL-6788867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3K phosphorylates ketosamines (Caenorhabditis elegans)
RHEA:51957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylpropanal oxime => (Z)-2-methylpropanal oxime
REACT:R-GGA-5654664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS binds GRB2:SOS1 (Gallus gallus)
RHEA:71989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + fusoxypene C => (2E,6E,10E,14E)-geranylfarnesyl diphosphate
RHEA:28279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine + H2O => H(+) + L-alanine + sulfite
RHEA:39331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)
RHEA:60393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)
RHEA:61033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine => 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:22973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + CoA + NADP(+) => butanoyl-CoA + H(+) + NADPH
REACT:R-HSA-5696810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase P cleaves the 5' end of pre-tRNA (Homo sapiens)
RHEA:58552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate II + H2O = (16R)-deshydroxymethyl-stemmadenine + formate
RHEA:55118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+) => 5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH
GO:0047485	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amino-terminus binding
GO:0047485	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NH2-terminal binding
GO:0047485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein N-terminus binding
GO:0047485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal binding
GO:0047485	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amino-terminal binding
GO:0047485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal end binding
GO:0047485	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NH2-terminus binding
REACT:R-XTR-909552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 at Ser727 (Xenopus tropicalis)
REACT:R-CFA-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Canis familiaris)
REACT:R-MMU-1977959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with EGFR (Mus musculus)
RHEA:61710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + L-seryl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-seryl-5'-AMP
RHEA:66674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,7-dihydroxy-4-methylphthalide + H2O => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+)
REACT:R-SPO-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Schizosaccharomyces pombe)
REACT:R-SSC-9025152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Sus scrofa)
REACT:R-DRE-266350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP-mediated lipid exchange: LDL gains cholesterol ester (Danio rerio)
REACT:R-SSC-193682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves the p75NTR transmembrane domain (Sus scrofa)
REACT:R-BTA-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Bos taurus)
RHEA:26323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine => resorcinol + S-adenosyl-L-methionine
RHEA:58401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptan-1-ol + NADP(+) => H(+) + heptanal + NADPH
REACT:R-CFA-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)
REACT:R-HSA-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-CFA-211991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclophosphamide is 4-hydroxylated by CYP2B6 (Canis familiaris)
REACT:R-DRE-749448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Danio rerio)
RHEA:26274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-3 + S-adenosyl-L-methionine => Co-precorrin-4 + S-adenosyl-L-homocysteine
RHEA:16316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)
REACT:R-GGA-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Gallus gallus)
GO:0102658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-5-methylthiopentanoate aminotransferase activity
REACT:R-MMU-561253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A12 exchanges extracellular urate for cytosolic LACT (Mus musculus)
REACT:R-PFA-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)
REACT:R-DRE-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Danio rerio)
REACT:R-HSA-936378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)
GO:0033713	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	choline oxidase activity
GO:0033713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline:oxygen 1-oxidoreductase activity
REACT:R-MMU-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
REACT:R-DRE-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Danio rerio)
REACT:R-DDI-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Dictyostelium discoideum)
REACT:R-RNO-2130282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated beta catenin by the proteasome (Rattus norvegicus)
GO:0102532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genkwanin 6-hydroxylase activity
REACT:R-GGA-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Gallus gallus)
REACT:R-XTR-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Xenopus tropicalis)
REACT:R-HSA-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)
RHEA:12810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 catechol + 3 O2 => 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O
REACT:R-DRE-176298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of claspin (Danio rerio)
REACT:R-BTA-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Bos taurus)
RHEA:46419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-5665727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds CDC42:GTP (Drosophila melanogaster)
REACT:R-HSA-913446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-5 is a homodimer (Homo sapiens)
REACT:R-SSC-913424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SHC1:SHIP1 complex is stabilized by GRB2 (Sus scrofa)
REACT:R-HSA-5624492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK phosphorylates p21 RAF1 on S338 (Homo sapiens)
RHEA:67944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoate + O2 = 2-oxohexadecanoate + H2O2
RHEA:63906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phenguignardate => 2 3-phenylpyruvate + H(+)
REACT:R-CEL-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Caenorhabditis elegans)
REACT:R-SPO-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Schizosaccharomyces pombe)
RHEA:39025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:70148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:52539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + dGTP <=> AMP + dGDP + H(+)
RHEA:31670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
RHEA:46118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-galactonate
RHEA:28398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate
RHEA:14036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-1D-myo-inositol <=> 1D-myo-inositol 1-phosphate + glycerol + H(+)
REACT:R-CFA-5654428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates SHC1 (Canis familiaris)
RHEA:38280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalate + succinyl-CoA => (3R)-citramalyl-CoA + succinate
REACT:R-RNO-8948066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-IRAK1 dissociates (Rattus norvegicus)
REACT:R-DME-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Drosophila melanogaster)
REACT:R-BTA-5694487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A4GNT transfers GlcNAc to core 2 mucins (Bos taurus)
REACT:R-HSA-9028260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	δ12-PGJ3 spontaneously dehydrates to  15d-PGJ3 (Homo sapiens)
REACT:R-RNO-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Rattus norvegicus)
RHEA:13526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]
RHEA:45624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine = AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]
RHEA:45624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase"
RHEA:45624	skos:altLabel	"L-allo-isoleucine:holo-[CmaA peptidyl-carrier protein] ligase"
RHEA:45624	skos:prefLabel	"L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase"
REACT:R-DME-6805470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates TP53 (Drosophila melanogaster)
RHEA:63231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + spectinomycin <=> 9-O-adenylylspectinomycin + diphosphate
RHEA:41824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)
REACT:R-XTR-2002401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Xenopus tropicalis)
RHEA:67515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:38856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CFA-71260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)
RHEA:31630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethynolide + dTDP-alpha-D-desosamine <=> 10-deoxymethymycin + dTDP + H(+)
REACT:R-GGA-1227709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MDA5 binds IPS-1 (Gallus gallus)
REACT:R-CEL-3968414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Caenorhabditis elegans)
REACT:R-GGA-199863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate NR4A1 (NUR77) (Gallus gallus)
REACT:R-DRE-264435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the COP1-p53 complex (Danio rerio)
REACT:R-XTR-4085028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE phosphorylates ManNAc to ManNAc-6-P (Xenopus tropicalis)
REACT:R-CFA-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Canis familiaris)
REACT:R-HSA-6784622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA4,APOA5,APOC2,CIDEC,FGF21 genes express APOA4,APOA5,APOC2,CIDEC,FGF21 proteins (Homo sapiens)
RHEA:56582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine => 6-thioguanine + S-adenosyl-L-methionine
REACT:R-BTA-8987042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)
GO:0050591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nifedipine oxidase activity
GO:0050591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinine,NADPH:oxygen oxidoreductase activity
GO:0050591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinine 3-hydroxylase activity
GO:0050591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinine 3-monooxygenase activity
REACT:R-SCE-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Saccharomyces cerevisiae)
REACT:R-XTR-3928640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs phosphorylate MLC (Xenopus tropicalis)
REACT:R-HSA-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)
REACT:R-HSA-389758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
RHEA:23655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-glutaminyl-[peptide] <=> N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)
RHEA:19483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipyl-CoA + CoA => acetyl-CoA + succinyl-CoA
RHEA:57689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[corrinoid adenosyltransferase] + cob(II)inamide => cob(II)inamide-[corrinoid adenosyltransferase]
RHEA:39161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + H2O => (3R)-hydroxyhexadecanoyl-CoA
RHEA:63545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kinetensin => kinetensin-(1-8) + L-leucine
RHEA:50082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + taurodeoxycholate(out) => ATP + H2O + taurodeoxycholate(in)
REACT:R-SSC-2426471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Sus scrofa)
RHEA:11396	skos:prefLabel	"5-methyldeoxycytidine-5'-phosphate kinase"
RHEA:11396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyldeoxycytidine 5'-phosphate + ATP = 5-methyldeoxycytidine diphosphate + ADP
RHEA:11396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-methyldeoxycytidine-5'-phosphate kinase"
REACT:R-GGA-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
REACT:R-RNO-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Rattus norvegicus)
REACT:R-CFA-114275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BAX at the mitochondrial membrane (Canis familiaris)
REACT:R-PFA-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Plasmodium falciparum)
GO:0052724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol hexakisphosphate 3-kinase activity
REACT:R-DME-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)
REACT:R-GGA-9615249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBs bind AGRT1 (Gallus gallus)
RHEA:22932	skos:altLabel	"GalT"
RHEA:22932	skos:altLabel	"thyroid galactosyltransferase"
RHEA:22932	skos:altLabel	"UDP-galactose--glycoprotein galactosyltransferase"
RHEA:22932	skos:prefLabel	"beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase"
RHEA:22932	skos:altLabel	"glycoprotein 4-beta-galactosyltransferase"
RHEA:22932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase"
RHEA:22932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-DRE-9027281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Danio rerio)
REACT:R-HSA-9729437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 N binds to TRIM25 (Homo sapiens)
RHEA:70328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) => 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH
REACT:R-RNO-5651739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Rattus norvegicus)
RHEA:48110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine
REACT:R-SSC-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Sus scrofa)
REACT:R-SSC-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Sus scrofa)
REACT:R-RNO-8949661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Rattus norvegicus)
GO:0103027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN phosphatase activity
REACT:R-DRE-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Danio rerio)
RHEA:51825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + octanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)
REACT:R-HSA-352379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Homo sapiens)
GO:0004118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
RHEA:16740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene <=> (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)
REACT:R-MMU-8982162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Mus musculus)
RHEA:36734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-nitrocyclohexan + NADP(+) <=> 1-nitrocyclohexene + H(+) + NADPH
REACT:R-DRE-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Danio rerio)
REACT:R-HSA-429732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Homo sapiens)
REACT:R-XTR-9718394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide antagonists (Xenopus tropicalis)
REACT:R-DDI-6806674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Dictyostelium discoideum)
RHEA:62649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate
REACT:R-MMU-9606887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CD19:VAV binds PI3K and GRB2 (Mus musculus)
RHEA:71713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-tyrosylglycine(in) => H(+)(out) + L-tyrosylglycine(out)
RHEA:33349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NH4(+) => 2-iminoacetate + H2O
RHEA:13590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate => 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate
REACT:R-DRE-8937419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBR3 reduces DOX to DOXOL (Danio rerio)
REACT:R-GGA-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Gallus gallus)
REACT:R-GGA-6814418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes formation of G-beta:G-gamma heterodimers (Gallus gallus)
RHEA:19902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 => alpha,beta-didehydrotryptophan + H2O2
RHEA:53829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 => a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate
REACT:R-HSA-392295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma recruits PI3K gamma (Homo sapiens)
REACT:R-HSA-202237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)
GO:0050573	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-4-keto-6-deoxyglucose reductase activity
GO:0050573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxyglucose reductase activity
GO:0050573	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-D-fucose:NADP+ oxidoreductase activity
REACT:R-SSC-8944219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVI (Sus scrofa)
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hypoxanthine-guanine phosphoribosyltransferase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HGPRTase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP:diphosphate phospho-D-ribosyltransferase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine 5'-phosphate pyrophosphorylase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine-6-thiol phosphoribosyltransferase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosinic pyrophosphorylase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosinate pyrophosphorylase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-mercaptopurine phosphoribosyltransferase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP diphosphorylase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HPRT
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine phosphoribosyltransferase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP pyrophosphorylase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosinic acid pyrophosphorylase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Transphosphoribosidase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	guanine-hypoxanthine phosphoribosyltransferase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP-GMP pyrophosphorylase activity
GO:0004422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxypurine phosphoribosyltransferase activity
RHEA:39031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP
RHEA:33214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-7 + CO2 + diphosphate
RHEA:30802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH
RHEA:70132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
REACT:R-RNO-5694431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Rattus norvegicus)
REACT:R-GGA-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Gallus gallus)
REACT:R-CEL-2731141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds fibronectin (Caenorhabditis elegans)
REACT:R-RNO-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Rattus norvegicus)
RHEA:41140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)
RHEA:48333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
REACT:R-BTA-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Bos taurus)
RHEA:13561	skos:prefLabel	"diaminopimelate dehydrogenase"
RHEA:13561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diaminopimelate dehydrogenase"
RHEA:13561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)
RHEA:13561	skos:altLabel	"meso-diaminopimelate D-dehydrogenase"
REACT:R-SSC-5138433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Sus scrofa)
REACT:R-DRE-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Danio rerio)
REACT:R-RNO-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Rattus norvegicus)
REACT:R-BTA-3204318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Bos taurus)
GO:1990856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionyl-initiator methionine tRNA binding
RHEA:70586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:38459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA = 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA
RHEA:38459	skos:prefLabel	"mycolipenoyl-CoA--2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase"
RHEA:38459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycolipenoyl-CoA--2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase"
RHEA:49365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate
REACT:R-MMU-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Mus musculus)
REACT:R-XTR-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)
REACT:R-DME-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Drosophila melanogaster)
EC:3.4.24.67	skos:altLabel	"high choriolytic enzyme"
EC:3.4.24.67	skos:prefLabel	"choriolysin H"
EC:3.4.24.67	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choriolysin H"
EC:3.4.24.67	skos:altLabel	"teleost hatching enzyme"
REACT:R-SSC-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Sus scrofa)
REACT:R-DME-109341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Drosophila melanogaster)
REACT:R-BTA-8932633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Bos taurus)
REACT:R-RNO-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Rattus norvegicus)
RHEA:50539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E2 <=> H2O + prostaglandin A2
REACT:R-BTA-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Bos taurus)
REACT:R-DDI-9027633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Dictyostelium discoideum)
REACT:R-DDI-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)
REACT:R-DRE-5218824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds FYN (Danio rerio)
RHEA:29622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltotetraose + beta-maltose <=> alpha-maltopentaose + beta-D-glucose
REACT:R-CEL-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
GO:0018707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenanthrol methyltransferase activity
REACT:R-DRE-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Danio rerio)
REACT:R-HSA-3857308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CEBPB and NFKB complex bind IL8 promoter (Homo sapiens)
REACT:R-CFA-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Canis familiaris)
RHEA:32136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DRE-8951966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates RUNX3 (Danio rerio)
RHEA:23924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pppGp(2'-5')A = 2',3'-cGAMP + diphosphate
REACT:R-DRE-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Danio rerio)
GO:0052637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity
REACT:R-DRE-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Danio rerio)
RHEA:27522	skos:prefLabel	"2,5-dihydroxypyridine 5,6-dioxygenase"
RHEA:27522	skos:altLabel	"2,5-dihydroxypyridine oxygenase"
RHEA:27522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,5-dihydroxypyridine 5,6-dioxygenase"
RHEA:27522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxypyridine + O2 = H(+) + N-formylmaleamate
RHEA:27522	skos:altLabel	"pyridine-2,5-diol dioxygenase"
REACT:R-CFA-8932275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Canis familiaris)
REACT:R-HSA-5617458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA1 mRNA is translated (Homo sapiens)
REACT:R-GGA-5685604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF6 binds SLAMF6 (Gallus gallus)
RHEA:33902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose <=> FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose
RHEA:30604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + A => AH2 + all-trans-phytofluene
REACT:R-HSA-168324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conformation change in hemagglutinin freeing the fusion peptide of HA2 (Homo sapiens)
RHEA:47251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate
REACT:R-XTR-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Xenopus tropicalis)
RHEA:37576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:22888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylmalonyl-CoA mutase"
RHEA:22888	skos:altLabel	"(S)-methylmalonyl-CoA mutase"
RHEA:22888	skos:altLabel	"methylmalonyl coenzyme A carbonylmutase"
RHEA:22888	skos:altLabel	"(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase"
RHEA:22888	skos:prefLabel	"methylmalonyl-CoA mutase"
RHEA:22888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-methylmalonyl-CoA = succinyl-CoA
RHEA:22888	skos:altLabel	"methylmalonyl-CoA CoA-carbonyl mutase"
RHEA:22888	skos:altLabel	"methylmalonyl coenzyme A mutase"
EC:1.12.1.3	skos:altLabel	"NADP(+)-reducing hydrogenase"
EC:1.12.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrogen dehydrogenase (NADP(+))"
EC:1.12.1.3	skos:altLabel	"NADP(+)-linked hydrogenase"
EC:1.12.1.3	skos:prefLabel	"hydrogen dehydrogenase (NADP(+))"
GO:0033221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled urea transmembrane transporter activity
GO:0033221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent urea transmembrane transporter activity
GO:0033221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea-transporting ATPase activity
GO:0033221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + urea(out) = ADP + H(+) + phosphate + urea(in)
GO:0033221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamide-transporting ATPase activity
REACT:R-XTR-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Xenopus tropicalis)
REACT:R-GGA-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Gallus gallus)
RHEA:71706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurocholate(out) <=> taurocholate(in)
RHEA:51394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(9Z-octadecenoyl)-serotonin => (9Z)-octadecenoyl-CoA + serotonin
REACT:R-RNO-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)
RHEA:49592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutanoyl-CoA = (3S)-3-hydroxybutanoyl-CoA
RHEA:49592	skos:prefLabel	"2-hydroxyisobutanoyl-CoA mutase"
RHEA:49592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyisobutanoyl-CoA mutase"
REACT:R-SSC-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Sus scrofa)
REACT:R-RNO-983707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates at the activated BCR (Rattus norvegicus)
REACT:R-DRE-377186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Danio rerio)
RHEA:26182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O
RHEA:71779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate(out) + H(+)(out) = 4-methyl-2-oxopentanoate(in) + H(+)(in)
REACT:R-CEL-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Caenorhabditis elegans)
RHEA:50072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + tauroursodeoxycholate(in) = ADP + H(+) + phosphate + tauroursodeoxycholate(out)
REACT:R-GGA-9731393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA, EDNRB bind non-selective ERAs (Gallus gallus)
REACT:R-SSC-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Sus scrofa)
REACT:R-DRE-5668714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX1 complex (Danio rerio)
REACT:R-HSA-391156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ITIM motif in SIRP alpha (Homo sapiens)
REACT:R-XTR-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Xenopus tropicalis)
REACT:R-BTA-112042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid binds MOR (Bos taurus)
REACT:R-DRE-446694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 phosphorylates IRAK1 (Danio rerio)
REACT:R-BTA-5685604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF6 binds SLAMF6 (Bos taurus)
RHEA:41012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)
RHEA:59899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-propargylglycine <=> ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate
REACT:R-CFA-5635843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI translocates to the nucleus (Canis familiaris)
REACT:R-SCE-390329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of AKT by PP2A (Saccharomyces cerevisiae)
REACT:R-RNO-164617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of Extended Telomeric Chromosome End (Rattus norvegicus)
REACT:R-RNO-8854071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome-mediated degradation of PolyUb-FBXL7 (Rattus norvegicus)
RHEA:42524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA
RHEA:42524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA pseudouridine(1911/1915/1917) synthase"
RHEA:42524	skos:prefLabel	"23S rRNA pseudouridine(1911/1915/1917) synthase"
REACT:R-HSA-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)
REACT:R-SPO-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Schizosaccharomyces pombe)
RHEA:67168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-hydroxy-L-phenylalanine = 3-(3-hydroxyphenyl)pyruvate + L-glutamate
RHEA:23981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclomaltodextrin + H2O => linear maltodextrin
REACT:R-DDI-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Dictyostelium discoideum)
RHEA:65502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine
RHEA:15926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrobunolol + NADP(+) => bunolol + H(+) + NADPH
RHEA:27279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH
RHEA:27685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dTDP <=> ADP + dTTP
REACT:R-CEL-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Caenorhabditis elegans)
REACT:R-HSA-997381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDPK phosphorylates ThDP to ThTP (Homo sapiens)
GO:0140616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine iodinase activity
GO:0140616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iodotyrosine deiodase activity
GO:0140616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodotyrosine deiodinase activity
GO:0140616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoiodotyrosine deiodinase activity
GO:0140616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iodide peroxidase-tyrosine iodinase activity
REACT:R-BTA-9653514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17L2 deubiquitinates RCE1 (Bos taurus)
RHEA:58970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthoate + H(+) + H2O2 => 1-naphthaldehyde + H2O + O2
RHEA:40353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP
REACT:R-RNO-3878123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of SAHF formation (Rattus norvegicus)
REACT:R-MMU-5635860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Mus musculus)
REACT:R-HSA-420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretin receptor binds secretin (Homo sapiens)
REACT:R-CFA-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Canis familiaris)
REACT:R-XTR-389158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
REACT:R-CFA-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Canis familiaris)
REACT:R-HSA-977619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)
REACT:R-HSA-193711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
REACT:R-RNO-389424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The orphan QRFP receptor can bind neuropeptide QRFP (Rattus norvegicus)
RHEA:17525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biuret amidohydrolase"
RHEA:17525	skos:prefLabel	"biuret amidohydrolase"
RHEA:17525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biuret + H2O = NH4(+) + urea-1-carboxylate
RHEA:23613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-alpha-santonin + NAD(+) => alpha-santonin + H(+) + NADH
REACT:R-CFA-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Canis familiaris)
REACT:R-SSC-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Sus scrofa)
REACT:R-DRE-159425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
REACT:R-MMU-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Mus musculus)
RHEA:71114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + S-methylmercury-L-cysteine(in) <=> L-phenylalanine(in) + S-methylmercury-L-cysteine(out)
REACT:R-RNO-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Rattus norvegicus)
RHEA:13041	skos:altLabel	"DCF"
RHEA:13041	skos:altLabel	"dopachrome Delta-isomerase"
RHEA:13041	skos:altLabel	"dopachrome keto-enol isomerase"
RHEA:13041	skos:altLabel	"L-dopachrome-methyl ester tautomerase"
RHEA:13041	skos:altLabel	"dopachrome isomerase"
RHEA:13041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-dopachrome isomerase"
RHEA:13041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopachrome = 5,6-dihydroxyindole-2-carboxylate
RHEA:13041	skos:altLabel	"DCT"
RHEA:13041	skos:prefLabel	"L-dopachrome isomerase"
RHEA:13041	skos:altLabel	"dopachrome Delta(7),Delta(2)-isomerase"
RHEA:13041	skos:altLabel	"dopachrome tautomerase"
RHEA:13041	skos:altLabel	"TRP"
RHEA:13041	skos:altLabel	"tyrosinase-related protein 2"
RHEA:13041	skos:altLabel	"dopachrome oxidoreductase"
RHEA:13041	skos:altLabel	"dopachrome rearranging enzyme"
RHEA:13041	skos:altLabel	"dopachrome conversion factor"
RHEA:69131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-leucine <=> 4-methyl-2-oxopentanoate + glycine
RHEA:54261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparaginyl-[protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate
RHEA:59606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+) => H2O + O2 + spermidine
REACT:R-DDI-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Dictyostelium discoideum)
REACT:R-BTA-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Bos taurus)
REACT:R-SSC-73718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBF-1 Binds rDNA Promoter (Sus scrofa)
REACT:R-RNO-450333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)
RHEA:17400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + NADP(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADPH
REACT:R-DDI-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Dictyostelium discoideum)
REACT:R-XTR-8956684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH polyubiquitinates TP73 (Xenopus tropicalis)
RHEA:14319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + morphinone + NADH => morphine + NAD(+)
RHEA:34400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-beta-carotene + O2 => 9-cis-10'-apo-beta-carotenal + beta-ionone
RHEA:68656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxocholesterol + H(+) + NADPH = 7beta-hydroxycholesterol + NADP(+)
RHEA:69716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + ATP + CoA => (indol-3-yl)acetyl-CoA + AMP + diphosphate
RHEA:64398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-sarcosine(in) + H(+)(in) => glycyl-sarcosine(out) + H(+)(out)
RHEA:36522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexacosanoyl-CoA + malonyl-CoA <=> 3-oxooctacosanyol-CoA + CO2 + CoA
RHEA:28998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-threonine(in) <=> H(+)(in) + L-threonine(out)
RHEA:30567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrahydrosarcinapterin synthase"
RHEA:30567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate = 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate
RHEA:30567	skos:prefLabel	"tetrahydrosarcinapterin synthase"
REACT:R-XTR-5223313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Xenopus tropicalis)
REACT:R-HSA-9673757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)
RHEA:57061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)
RHEA:10837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + questin => demethylsulochrin + NADP(+)
REACT:R-RNO-444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR5 binds CXCL13 (Rattus norvegicus)
RHEA:31677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + perakine => NADP(+) + raucaffrinoline
RHEA:44456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine
GO:0005034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	osmosensor activity
REACT:R-RNO-193070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPREG to DHA (Rattus norvegicus)
REACT:R-HSA-170835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)
RHEA:29140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + menaquinol-8 + nitrate => 2 H(+)(out) + H2O + menaquinone-8 + nitrite
RHEA:44929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoheptanedioate + acetyl-CoA + H2O => (R)-trihomocitrate + CoA + H(+)
RHEA:58865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:34042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + neamine <=> 6'-oxoparomamine + L-glutamate
RHEA:13481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
RHEA:13481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionine--tRNA ligase"
RHEA:13481	skos:altLabel	"MetRS"
RHEA:13481	skos:altLabel	"methionyl-transfer ribonucleate synthetase"
RHEA:13481	skos:prefLabel	"methionine--tRNA ligase"
RHEA:13481	skos:altLabel	"methionine translase"
RHEA:13481	skos:altLabel	"methionyl-transfer RNA synthetase"
RHEA:13481	skos:altLabel	"methionyl-transfer ribonucleic acid synthetase"
RHEA:13481	skos:altLabel	"methionyl-tRNA synthetase"
RHEA:24188	skos:prefLabel	"dibenzothiophene dihydrodiol dehydrogenase"
RHEA:24188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dibenzothiophene dihydrodiol dehydrogenase"
RHEA:24188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH
REACT:R-XTR-870479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) binds to ubiquitinated SMAD4 (Xenopus tropicalis)
RHEA:48889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione => (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
REACT:R-PFA-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Plasmodium falciparum)
REACT:R-HSA-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)
REACT:R-CFA-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Canis familiaris)
REACT:R-GGA-210881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Tie2/Ang1 complex (Gallus gallus)
GO:0071723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bacterial lipoprotein binding
GO:0071723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopeptide binding
GO:0071723	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial lipopeptide binding
REACT:R-RNO-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Rattus norvegicus)
RHEA:63452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized 3PG-factor420-0
RHEA:63452	skos:prefLabel	"2-phospho-L-lactate transferase"
RHEA:63452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-phospho-L-lactate transferase"
RHEA:37299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-threonine = L-alanine + L-threonine
REACT:R-CFA-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Canis familiaris)
REACT:R-BTA-8932355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades Ub-NFE2L2 (Bos taurus)
REACT:R-HSA-8864412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A,TFAP2C homodimers bind the CGA gene (Homo sapiens)
REACT:R-RNO-162730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Rattus norvegicus)
RHEA:70585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA
REACT:R-RNO-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Rattus norvegicus)
REACT:R-RNO-4084984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Rattus norvegicus)
RHEA:59802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-DDI-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Dictyostelium discoideum)
RHEA:18896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP
REACT:R-GGA-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Gallus gallus)
RHEA:39109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate
RHEA:63741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + H(+) + NADH => 2-phenylethanol + NAD(+)
REACT:R-DRE-76354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vinyl chloride is oxidized to 2-Chloroethylene oxide (Danio rerio)
RHEA:72912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proatranorin III + S-adenosyl-L-methionine => atranorin + S-adenosyl-L-homocysteine
REACT:R-GGA-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Gallus gallus)
GO:0103001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylsulfoxide oxygenase activity
REACT:R-MMU-6793661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Mus musculus)
RHEA:72437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + AMP + H(+) => (E)-caffeoyl-AMP + CoA
GO:0052627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vanillate amino acid synthetase activity
REACT:R-CFA-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
REACT:R-SSC-2022056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPG and CSPG translocate to the lysosome for degradation (Sus scrofa)
RHEA:19598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine => L-citrulline + NH4(+)
RHEA:30884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucurono-3,6-lactone + 2 H2O + NAD(+) => D-glucarate + 3 H(+) + NADH
REACT:R-RNO-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Rattus norvegicus)
GO:0106238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peregrinol diphosphate synthase activity
RHEA:36983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA
REACT:R-RNO-111238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR2  homodimer (Rattus norvegicus)
RHEA:54326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin]
RHEA:59668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellohexaose + O2 = D-cellohexaono-1,5-lactone + H2O2
REACT:R-MMU-9610750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Mus musculus)
GO:0018582	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-hydroxy-2-naphthoate-degrading enzyme activity
GO:0018582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate 1,2-dioxygenase activity
GO:0018582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)
GO:0018582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-hydroxy-2-naphthoic acid dioxygenase activity
GO:0018582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate dioxygenase activity
REACT:R-SSC-6786050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Sus scrofa)
GO:0034571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
REACT:R-GGA-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Gallus gallus)
RHEA:36457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-alanylglycine(in) + phosphate => ATP + H2O + L-alanylglycine(out)
REACT:R-CFA-9627350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) binds XIAP (Canis familiaris)
RHEA:72453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in) => a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out)
REACT:R-XTR-428518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glypican-1 (GPC1) binds SLIT2 (Xenopus tropicalis)
REACT:R-XTR-9769235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGED1 binds NPAS4 (Xenopus tropicalis)
RHEA:55552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine
RHEA:33973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + ribostamycin => 5''-phosphoribostamycin + H2O
RHEA:58952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh1 + H(+) + UDP
REACT:R-HSA-9625913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypochlorous acid (HOCL) reacts with Lys-monochloramine (Homo sapiens)
RHEA:18076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + A <=> AH2 + orotate
REACT:R-SSC-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Sus scrofa)
REACT:R-DRE-173626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1r (Danio rerio)
RHEA:14367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-aspartate + NH4(+) => 2 H(+) + H2O + N-carbamoyl-L-aspartate
RHEA:23107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose 5-phosphate <=> D-ribulose 5-phosphate
REACT:R-SSC-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Sus scrofa)
RHEA:61746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stevioside + UDP => steviolbioside + UDP-alpha-D-glucose
REACT:R-DRE-428609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type I Na+-coupled phosphate co-transport (Danio rerio)
RHEA:26428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CTP + 2 H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + UTP
RHEA:17889	skos:altLabel	"amino alcohol O-phosphate phospholyase"
RHEA:17889	skos:altLabel	"O-phosphoethanolamine-phospholyase"
RHEA:17889	skos:prefLabel	"ethanolamine-phosphate phospho-lyase"
RHEA:17889	skos:altLabel	"O-phosphorylethanol-amine phospho-lyase"
RHEA:17889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethanolamine-phosphate phospho-lyase"
RHEA:17889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphoethanolamine = acetaldehyde + NH4(+) + phosphate
REACT:R-CFA-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Canis familiaris)
REACT:R-SSC-448702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-1 active tetramer formation (Sus scrofa)
RHEA:60362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydro coenzyme F420-0 + FMNH2 => FMN + H(+) + oxidized coenzyme F420-0
RHEA:38665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in)
REACT:R-HSA-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Homo sapiens)
RHEA:44222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxypentadecanoyl-CoA + AMP + diphosphate => 15-hydroxypentadecanoate + ATP + CoA
REACT:R-SSC-176664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + PAPS => estrone 3-sulfate + PAP (Sus scrofa)
REACT:R-DDI-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Dictyostelium discoideum)
GO:0030169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL binding
GO:0030169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-density lipoprotein particle binding
REACT:R-HSA-6798129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the CASP6 gene (Homo sapiens)
GO:0047112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate oxidase activity
GO:0047112	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:oxygen 2-oxidoreductase (phosphorylating)
GO:0047112	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphate-dependent pyruvate oxidase activity
GO:0047112	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic oxidase activity
REACT:R-HSA-1236971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peptide loading on MHC class I in phagosome (Homo sapiens)
REACT:R-BTA-1181153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Bos taurus)
RHEA:59866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-glutamine
RHEA:49862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-202325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Gads to LAT (Canis familiaris)
RHEA:68212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA
RHEA:23911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine <=> 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine
RHEA:31930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Canis familiaris)
REACT:R-SSC-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Sus scrofa)
REACT:R-GGA-450490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B/Akt phosphorylates BRF1 (Gallus gallus)
REACT:R-SSC-5579023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA2(869-1464) binds KAT6A(1-1118) (Sus scrofa)
RHEA:62996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)-eicosatrienoate + NH4(+)
REACT:R-DME-1964501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Drosophila melanogaster)
RHEA:41900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-MMU-430135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds ADAP (Mus musculus)
RHEA:62098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + phosphate => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
REACT:R-HSA-443779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Linkage of L1 with treadmilling F-actin (Homo sapiens)
RHEA:16808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + deacetoxycephalosporin C + O2 <=> CO2 + deacetylcephalosporin C + succinate
REACT:R-MMU-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Mus musculus)
REACT:R-SSC-182969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:CBL) (Sus scrofa)
RHEA:17538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinamide + H2O => (R)-carnitine + NH4(+)
REACT:R-DRE-8868659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)
REACT:R-SSC-388829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 phosphatase binds CTLA-4 (Sus scrofa)
REACT:R-CFA-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Canis familiaris)
GO:0018595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene monooxygenase activity
RHEA:47210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:39033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose
REACT:R-CFA-8858252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDLBP binds HDL (Canis familiaris)
REACT:R-CFA-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Canis familiaris)
RHEA:48898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transfer ribonucleic-terminal trinucleotide nucleotidyltransferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transfer ribonucleate adenylyltransferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CTP:tRNA cytidylyltransferase activity
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transfer ribonucleate nucleotidyltransferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP(CTP)-tRNA nucleotidyltransferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CCA-adding enzyme activity
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCA tRNA nucleotidyltransferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA CCA-diphosphorylase activity
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transfer ribonucleic acid nucleotidyl transferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribonucleic cytidylyltransferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transfer ribonucleic adenylyl (cytidylyl) transferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transfer RNA adenylyltransferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate adenyltransferase activity
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tRNA-nucleotidyltransferase activity
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tRNA adenylyl(cytidylyl)transferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP(CTP):tRNA nucleotidyltransferase activity
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA cytidylyltransferase activity
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transfer-RNA nucleotidyltransferase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribonucleic cytidylic cytidylic adenylic pyrophosphorylase
GO:0004810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CTP(ATP):tRNA nucleotidyltransferase
REACT:R-MMU-205008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF binds to p62 (Sequestosome) (Mus musculus)
REACT:R-SCE-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Saccharomyces cerevisiae)
REACT:R-SSC-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Sus scrofa)
REACT:R-SSC-195408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Sus scrofa)
REACT:R-GGA-4420143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SH2D2A (Gallus gallus)
RHEA:19939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + sarcosine => glycine + S-adenosyl-L-methionine
REACT:R-HSA-9757462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroxyl radicals oxidize ST to 2,3-DHBA (Homo sapiens)
REACT:R-RNO-5218854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y420-FYN is phosphorylated on S21 (Rattus norvegicus)
REACT:R-DRE-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Danio rerio)
REACT:R-SSC-5099899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD4 (Sus scrofa)
REACT:R-HSA-549355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRY proteins stabilize unphosphorylated BMAL1:CLOCK,NPAS2 (Homo sapiens)
GO:0031955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	short-chain fatty-acid-CoA ligase activity
GO:0031955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short-chain fatty acid activation
GO:0031955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	short-chain-fatty-acid-CoA ligase activity
GO:0031955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	short-chain fatty acid-CoA ligase activity
RHEA:37652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:53557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:36511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA
REACT:R-SSC-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)
REACT:R-DDI-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Dictyostelium discoideum)
REACT:R-CEL-5672961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)
REACT:R-SSC-3928627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB phosphorylates TIAM1 (Sus scrofa)
REACT:R-HSA-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Homo sapiens)
RHEA:29210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol(in) + dimethyl sulfoxide(out) <=> a menaquinone(in) + dimethyl sulfide(out) + H2O(out)
REACT:R-MMU-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Mus musculus)
REACT:R-BTA-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Bos taurus)
REACT:R-SSC-8865237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD6 methylates RELA in the NFkB complex (Sus scrofa)
REACT:R-MMU-1112708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-Y759-IL6ST (Mus musculus)
RHEA:18683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine
RHEA:14998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxylimonoate + H2O => deoxylimononate D-ring-lactone + H(+)
GO:0033437	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine tRNA
GO:0033437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACU codon-amino acid adaptor activity
GO:0033437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACT codon-amino acid adaptor activity
EC:3.6.5.6	skos:prefLabel	"tubulin GTPase"
EC:3.6.5.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tubulin GTPase"
REACT:R-CEL-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Caenorhabditis elegans)
REACT:R-DRE-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Danio rerio)
RHEA:23025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n) + phosphate => [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
GO:0005462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine transmembrane transporter activity
GO:0050239	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity
GO:0050239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrithiamine deaminase activity
GO:0016788	skos:prefLabel	"Acting on ester bonds"
GO:0016788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on ester bonds"
GO:0016788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on ester bonds
GO:0016788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esterase activity
REACT:R-XTR-189398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)
RHEA:31285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + FADH2 => FAD + H(+) + sn-glycerol 3-phosphate
RHEA:51649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[protein] + O2 => (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2
RHEA:21022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + phosphate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate
RHEA:64030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine
REACT:R-HSA-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Homo sapiens)
REACT:R-BTA-428888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ROBO1 by ABL kinase (Bos taurus)
REACT:R-GGA-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Gallus gallus)
REACT:R-XTR-8851436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFHR dimers bind C3b (Xenopus tropicalis)
RHEA:58633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-tetradecanoyl-(2S)-hydroxyglycine => glyoxylate + tetradecamide
RHEA:33970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H(+)
REACT:R-BTA-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Bos taurus)
REACT:R-HSA-1462003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNP1-4 are stored in primary neutrophil granules (Homo sapiens)
REACT:R-DDI-5687183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKDC phosphorylates DCLRE1C at DNA DSBs (Dictyostelium discoideum)
REACT:R-RNO-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Rattus norvegicus)
REACT:R-CFA-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Canis familiaris)
RHEA:30621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-lycopene => 2 A + all-trans-zeta-carotene
RHEA:65109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene C + L-prolyl-[peptidyl-carrier protein] => aculene A + holo-[peptidyl-carrier protein]
GO:0047116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity
GO:0047116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHBDH activity
GO:0047116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydro-1,2-dihydroxybenzoate dehydrogenase activity
GO:0047116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrodihydroxybenzoate dehydrogenase activity
GO:0047116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity
GO:0047116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)
GO:0047116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity
GO:0047116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity
GO:0047116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity
GO:0047116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHB dehydrogenase activity
REACT:R-DDI-168405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD oligomer recruites RIP2 (RICK) (Dictyostelium discoideum)
REACT:R-MMU-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Mus musculus)
RHEA:57854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase => a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O
REACT:R-GGA-6803753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAAA hydrolyses NAEs to FAs and ethanolamine (Gallus gallus)
REACT:R-DRE-9027321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)
REACT:R-DME-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Drosophila melanogaster)
RHEA:20926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [peptide]-C-terminal amide + glyoxylate => a [peptide]-C-terminal (2S)-2-hydroxyglycine
REACT:R-GGA-6782138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC5 and RPA bind TC-NER site (Gallus gallus)
REACT:R-HSA-8944265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type IV (Homo sapiens)
REACT:R-SPO-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Schizosaccharomyces pombe)
RHEA:57011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,5'-dehydrodivanillate + H(+) + NADH + O2 <=> 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)
RHEA:31199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O
REACT:R-SSC-170978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-FRS2:CRKL binds C3G (Sus scrofa)
RHEA:38869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(516) in 16S rRNA => uridine(516) in 16S rRNA
RHEA:32608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-hydroxygeranial + H(+) + NADPH
GO:0047079	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity
GO:0047079	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyrimidine-deoxynucleoside 1'-dioxygenase activity
GO:0047079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyuridine 1'-dioxygenase activity
GO:0047079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)
REACT:R-GGA-433808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viral dsRNA: TLR3: TICAM1 recruits TRAF6 (Gallus gallus)
REACT:R-SSC-351894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of BAP31 (Sus scrofa)
RHEA:66924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA = [(R)-3-hydroxyalkanoate](n+1) + CoA
RHEA:57716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate + NH4(+) = carbamate + H(+) + H2O
RHEA:44664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-CEL-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Caenorhabditis elegans)
REACT:R-XTR-5654422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS2 (Xenopus tropicalis)
RHEA:44386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA
GO:0140818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA 5'-phosphatase activity
GO:0140818	skos:altLabel	"5'-polynucleotidase"
GO:0140818	skos:prefLabel	"mRNA 5'-phosphatase"
GO:0140818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate
GO:0140818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA 5'-triphosphate monophosphatase activity
GO:0140818	skos:altLabel	"mRNA 5'-triphosphate monophosphatase"
GO:0140818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mRNA 5'-phosphatase"
GO:0140818	skos:altLabel	"polynucleotide 5'-phosphohydrolase"
REACT:R-XTR-6811423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Xenopus tropicalis)
GO:0016822	skos:prefLabel	"Acting on carbon-carbon bonds"
GO:0016822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on carbon-carbon bonds"
GO:0016822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid carbon-carbon bonds
REACT:R-CEL-8959719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPK phosphorylates Sedo to Sedo7P (Caenorhabditis elegans)
REACT:R-MMU-4793911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates HSF1 (Mus musculus)
RHEA:11876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADH
RHEA:11876	skos:prefLabel	"15-hydroxyprostaglandin dehydrogenase (NAD(+))"
RHEA:11876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"15-hydroxyprostaglandin dehydrogenase (NAD(+))"
RHEA:11876	skos:altLabel	"15-hydroxyprostaglandin dehydrogenase"
REACT:R-CEL-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Caenorhabditis elegans)
REACT:R-HSA-70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Homo sapiens)
GO:0090562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity
GO:0031717	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cannabinoid receptor ligand
GO:0031717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabinoid receptor binding
REACT:R-SSC-114544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p115-RhoGEF activation of RHOA (Sus scrofa)
RHEA:36979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA
RHEA:41156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+)
REACT:R-DDI-8944246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXI (Dictyostelium discoideum)
REACT:R-HSA-5690740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds B-cell receptor (Homo sapiens)
REACT:R-SSC-1605717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Sus scrofa)
REACT:R-SSC-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Sus scrofa)
RHEA:53156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
RHEA:55654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O
RHEA:71059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-leucine(out) = L-arginine(out) + L-leucine(in)
REACT:R-DME-5674130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)
RHEA:63745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan-1-N-beta-D-glucuronide
REACT:R-SSC-2485182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Sus scrofa)
REACT:R-BTA-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Bos taurus)
REACT:R-DME-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Drosophila melanogaster)
RHEA:47846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + diphosphate + thiamine phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)
REACT:R-HSA-444171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR2 binds carboxylates (Homo sapiens)
GO:0042083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydrofolate-dependent methyltransferase activity
RHEA:25228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NAD(+) <=> H(+) + L-arabinose + NADH
REACT:R-RNO-392530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S400-Cot phosphorylates NIK (Rattus norvegicus)
RHEA:45103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-demethylmitomycin B + S-adenosyl-L-methionine <=> mitomycin B + S-adenosyl-L-homocysteine
REACT:R-CFA-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Canis familiaris)
RHEA:33113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-copaene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-HSA-421426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ProGIP translocates from the ER Lumen to secretory granules (Homo sapiens)
RHEA:68852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (1S,6S,7R)-sesquipiperitol + diphosphate
GO:0050096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)
GO:0050096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methylaspartase activity
GO:0050096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-methylaspartase activity
GO:0050096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threo-3-methylaspartate ammonia-lyase activity
GO:0050096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylaspartate ammonia-lyase activity
RHEA:37993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-tocopherol + H(+) + S-adenosyl-L-homocysteine => delta-tocopherol + S-adenosyl-L-methionine
REACT:R-HSA-749454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
GO:0140829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bicarbonate:anion antiporter activity
RHEA:34224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxypseudooxynicotine + A + H2O => 2,6-dihydroxypseudooxynicotine + AH2
GO:0050004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:isoflavone 7-O-glucosyltransferase activity
GO:0050004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity
GO:0050004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-flavonoid 7-O-glucosyltransferase activity
GO:0050004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity
GO:0050004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity
GO:0050004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoflavone 7-O-glucosyltransferase activity
RHEA:44720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + H(+) + phosphocholine
REACT:R-MMU-6807052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBP isomerizes ZYMSTNL to LTHSOL (Mus musculus)
REACT:R-RNO-443774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homodimerization of Neurofascin (Rattus norvegicus)
REACT:R-CEL-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Caenorhabditis elegans)
REACT:R-BTA-5205824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)
REACT:R-CFA-964811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5AR2 binds anaphylatoxins and thier desArginated derivatives (Canis familiaris)
RHEA:57907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate
REACT:R-DME-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Drosophila melanogaster)
REACT:R-GGA-198613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)
REACT:R-DDI-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Dictyostelium discoideum)
RHEA:20643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + L-histidine + 2 NADH => H2O + L-histidinol + 2 NAD(+)
GO:0033457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT codon-amino acid adaptor activity
GO:0033457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic acid tRNA
GO:0033457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAU codon-amino acid adaptor activity
RHEA:64653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaraldehyde + CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH
RHEA:62699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 4 tellimagrandin II <=> 2 cornusiin E + 2 H2O
REACT:R-CFA-1013020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Canis familiaris)
REACT:R-SPO-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Schizosaccharomyces pombe)
GO:1902249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP binding
REACT:R-DRE-2428926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Danio rerio)
REACT:R-HSA-9731077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 8b binds to IRF3 (Homo sapiens)
REACT:R-CEL-1602488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by plasmin and trypsin (Caenorhabditis elegans)
REACT:R-XTR-3928617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB2 binds KALRN (Xenopus tropicalis)
RHEA:22997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + L-ascorbate => 2 H2O + L-dehydroascorbate
REACT:R-DRE-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Danio rerio)
REACT:R-BTA-196126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from cytosol to mitochondrial intermembrane space (Bos taurus)
REACT:R-HSA-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Homo sapiens)
REACT:R-XTR-8848355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes retinyl palmitate (Xenopus tropicalis)
REACT:R-SPO-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Schizosaccharomyces pombe)
REACT:R-DME-114544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p115-RhoGEF activation of RHOA (Drosophila melanogaster)
REACT:R-RNO-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Rattus norvegicus)
RHEA:34839	skos:prefLabel	"5,7-dihydroxy-2-methylchromone synthase"
RHEA:34839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5,7-dihydroxy-2-methylchromone synthase"
RHEA:34839	skos:altLabel	"pentaketide chromone synthase"
RHEA:34839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 5 malonyl-CoA = 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O
RHEA:43761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]
RHEA:38432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)
REACT:R-RNO-8848247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD4,5 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)
REACT:R-RNO-6800490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates PIDD1 (Rattus norvegicus)
REACT:R-DRE-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Danio rerio)
REACT:R-SCE-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Saccharomyces cerevisiae)
REACT:R-SSC-5696230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO1 dimer reduces methylarsonate to methylarsonite (Sus scrofa)
REACT:R-DRE-9015111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors binds Xa (Danio rerio)
REACT:R-BTA-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Bos taurus)
RHEA:12597	skos:prefLabel	"phosphinothricin acetyltransferase"
RHEA:12597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + phosphinothricin = CoA + H(+) + N-acetylphosphinothricin
RHEA:12597	skos:altLabel	"PPT acetyltransferase"
RHEA:12597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphinothricin acetyltransferase"
RHEA:12597	skos:altLabel	"PPT N-acetyltransferase"
EC:3.5.1.52	skos:prefLabel	"peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase"
EC:3.5.1.52	skos:altLabel	"N-oligosaccharide glycopeptidase"
EC:3.5.1.52	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase"
EC:3.5.1.52	skos:altLabel	"N-glycanase"
EC:3.5.1.52	skos:altLabel	"glycopeptide N-glycosidase"
EC:3.5.1.52	skos:altLabel	"glycopeptidase"
RHEA:46095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]
GO:0047697	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)
GO:0047697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanopine dehydrogenase activity
GO:0047697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	b-alanopine dehydrogenase activity
GO:0016814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In cyclic amidines"
GO:0016814	skos:prefLabel	"In cyclic amidines"
GO:0016814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
RHEA:50830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2
REACT:R-CFA-9648268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A antagonists (Canis familiaris)
REACT:R-CFA-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Canis familiaris)
REACT:R-CFA-379382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates DA to DOPAC (Canis familiaris)
REACT:R-DRE-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Danio rerio)
REACT:R-HSA-9033491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Homo sapiens)
RHEA:19328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + quinolin-4-ol <=> H2O + NAD(+) + quinoline-3,4-diol
RHEA:24990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitroate + H2O + 2 oxidized [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-DME-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Drosophila melanogaster)
REACT:R-MMU-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Mus musculus)
REACT:R-DRE-176646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Danio rerio)
GO:0000007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity zinc ion transmembrane transporter activity
REACT:R-SSC-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Sus scrofa)
RHEA:51974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
GO:0008564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-exporting ATPase activity
GO:0008564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled protein transporter activity
RHEA:22320	skos:prefLabel	"maltose synthase"
RHEA:22320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 alpha-D-glucose 1-phosphate + H2O = D-maltose + 2 phosphate
RHEA:22320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maltose synthase"
REACT:R-GGA-437230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-FGFR cis-heterodimerization (Gallus gallus)
REACT:R-DME-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Drosophila melanogaster)
RHEA:42514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + acetate => 5-acetamidopentanoate + H2O
RHEA:65344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0089715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA m6t6A37 methyltransferase activity
REACT:R-DME-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)
REACT:R-CFA-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Canis familiaris)
REACT:R-MMU-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Mus musculus)
REACT:R-RNO-3076905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular BTD hydrolyses BCTN (Rattus norvegicus)
REACT:R-CFA-5633040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Canis familiaris)
RHEA:70988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(out) + n H(+)(in) => beta-alanine(in) + n H(+)(out)
GO:0033827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity
GO:0033827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase"
GO:0033827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity
GO:0033827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity
GO:0033827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity
GO:0033827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity
GO:0033827	skos:prefLabel	"high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase"
RHEA:27901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-AMP + H2O <=> adenosine + phosphate
GO:0033905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-xylanase activity
GO:0033905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-1,3-xylanase activity
GO:0033905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-xylanase activity
GO:0033905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylan endo-1,3-beta-xylosidase activity
GO:0033905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,3-xylanase activity
GO:0033905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,3-beta-xylanase activity
GO:0033905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,3-xylanase activity
GO:0033905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-xylan xylanohydrolase activity
GO:0033905	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	xylanase activity
RHEA:49025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 => 2-iminio-3-(indol-3-yl)propanoate + H2O2
REACT:R-DRE-216727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Danio rerio)
RHEA:17385	skos:prefLabel	"hypotaurine dehydrogenase"
RHEA:17385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hypotaurine dehydrogenase"
RHEA:17385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypotaurine + NAD(+) = H(+) + NADH + taurine
REACT:R-DME-209156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYD88 binds to TUB (Drosophila melanogaster)
REACT:R-BTA-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Bos taurus)
RHEA:58416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH
RHEA:14653	skos:altLabel	"cyclic AMP phosphodiesterase"
RHEA:14653	skos:prefLabel	"3',5'-cyclic-nucleotide phosphodiesterase"
RHEA:14653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3',5'-cyclic-nucleotide phosphodiesterase"
RHEA:14653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)
REACT:R-HSA-3928601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 and PIP2 bind WASL, activating it (Homo sapiens)
GO:0046974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 methylase activity
GO:0046974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3K9 methyltransferase activity
GO:0046974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-methyltransferase activity (H3-K9 specific)
GO:0046974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-K9 specific)
GO:0046974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 methyltransferase activity
GO:0046974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H3-K9 specific)
RHEA:20849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O2 + phosphate + pyruvate => acetyl phosphate + CO2 + H2O2
GO:0050695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylglyoxylate decarboxylase activity
GO:0050695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoylformate carboxy-lyase activity
GO:0050695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoylformate decarboxylase activity
GO:0050695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoylformate carboxy-lyase (benzaldehyde-forming)
REACT:R-BTA-3215295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates MDM2 (Bos taurus)
RHEA:47814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2
RHEA:71625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(in) + phosphate(out) => malonate(out) + phosphate(in)
REACT:R-BTA-9629470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Bos taurus)
REACT:R-SCE-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)
REACT:R-SSC-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Sus scrofa)
GO:0047793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cycloeucalenol--obtusifoliol isomerase activity
GO:0047793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloeucalenol-obtusifoliol isomerase activity
GO:0047793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cycloeucalenol lyase (cyclopropane-decyclizing)
GO:0047793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloeucalenol cycloisomerase activity
REACT:R-CFA-2309773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS2 (Canis familiaris)
REACT:R-HSA-9014587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcription of ROBO3.2 mRNA (Homo sapiens)
REACT:R-CEL-416559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)
RHEA:43685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate => AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]
REACT:R-DME-74220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Drosophila melanogaster)
REACT:R-CEL-751001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (i) reassociates with G beta:gamma (Caenorhabditis elegans)
REACT:R-DRE-158333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Danio rerio)
REACT:R-CFA-8862137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B2 oxidises estradiol (E2) to estrone (E1) (Canis familiaris)
REACT:R-DME-9021596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane estrogen receptors bind SRC (Drosophila melanogaster)
REACT:R-SSC-9696268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds effectors (Sus scrofa)
RHEA:40811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-DRE-5682598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates HERC2 (Danio rerio)
RHEA:33381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxyeicosasphinganine + phosphate => 4-hydroxyeicosasphinganine 1-phosphate + H2O
RHEA:19771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phaseollidin => phaseollidin hydrate
RHEA:64964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + 2 H2O = dUMP + 2 H(+) + 2 phosphate
REACT:R-MMU-1247922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCT transforms gGluCys to OPRO (Mus musculus)
RHEA:38380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-HSA-373750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:ErbB2 (Homo sapiens)
REACT:R-CFA-8943780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 recruits NuRD to PTEN gene (Canis familiaris)
REACT:R-DME-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Drosophila melanogaster)
RHEA:32462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine
RHEA:21806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + ADP + H(+) => ATP + myo-inositol
RHEA:12754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NADP(+) => dihydroxyacetone + H(+) + NADPH
RHEA:36482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA
REACT:R-HSA-9011145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHX2,(LHX9) binds the ROBO3 gene promoter (Homo sapiens)
REACT:R-DRE-5655835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Danio rerio)
REACT:R-RNO-416562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGAP binds Plexin-B1 (Rattus norvegicus)
REACT:R-CEL-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Caenorhabditis elegans)
REACT:R-SSC-163320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of mTERF with the termination sequence (Sus scrofa)
RHEA:13876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate <=> abieta-7,13-diene + diphosphate
GO:0008768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-sugar hydrolase activity
GO:0008768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-sugar diphosphatase activity
GO:0008768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-sugar sugarphosphohydrolase activity
GO:0008768	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleosidediphosphate-sugar diphosphatase activity
GO:0008768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-sugar pyrophosphatase activity
GO:0008768	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleosidediphosphate-sugar pyrophosphatase activity
GO:0016726	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0016726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
GO:0016726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
REACT:R-XTR-429767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Xenopus tropicalis)
GO:0072572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pADPr binding
GO:0072572	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	poly-ADP-ribose binding
GO:0072572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly-ADP-D-ribose binding
REACT:R-HSA-9683670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein E forms a homopentamer (Homo sapiens)
RHEA:66379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + H2O <=> D-erythrose + phosphate
RHEA:23929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(8)-acetylspermidine => acetate + spermidine
REACT:R-HSA-6803719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds ZNF385A (Homo sapiens)
REACT:R-DRE-174963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1 acetylation (Danio rerio)
RHEA:37499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-MMU-4420107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHC-transforming protein 2 (Mus musculus)
REACT:R-DDI-5218905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Dictyostelium discoideum)
RHEA:69021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NADPH + O2 => H2O + N-hydroxy-L-aspartate + NADP(+)
REACT:R-XTR-164617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of Extended Telomeric Chromosome End (Xenopus tropicalis)
REACT:R-BTA-419841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Light stimulates opsin receptors (Bos taurus)
RHEA:21887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trithionate <=> H(+) + sulfate + thiosulfate
RHEA:12587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyprogesterone <=> 16,17-didehydroprogesterone + H2O
RHEA:41694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:18836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-formylbenzenesulfonate + H2O + NAD(+) <=> 4-sulfobenzoate + 2 H(+) + NADH
REACT:R-CFA-446391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the PINCH-ILK-parvin complex (Canis familiaris)
REACT:R-MMU-9007926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATRX binds DAXX (Mus musculus)
RHEA:67434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-DME-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Drosophila melanogaster)
REACT:R-BTA-5675947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF18 binds TNFRSF18 (Bos taurus)
REACT:R-SSC-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Sus scrofa)
REACT:R-SSC-210285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homophilic interaction of PECAM-1 (Sus scrofa)
RHEA:35879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-PFA-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Plasmodium falciparum)
RHEA:66276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tigogenin + UDP-alpha-D-glucose = H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP
GO:0050261	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribose isomerase activity
GO:0050261	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribose aldose-ketose-isomerase activity
GO:0050261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose isomerase activity
GO:0050261	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribose ketol-isomerase activity
REACT:R-BTA-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Bos taurus)
REACT:R-XTR-174439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Xenopus tropicalis)
REACT:R-HSA-5578965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A binds AGO2:miRNA (Homo sapiens)
REACT:R-BTA-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Bos taurus)
GO:0034794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopropanecarboxyl-CoA decyclase activity
REACT:R-XTR-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Xenopus tropicalis)
REACT:R-HSA-8936584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
RHEA:39461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH
REACT:R-HSA-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)
RHEA:65830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + nerol => H2O + neryl diphosphate
RHEA:14872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative
RHEA:34515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP
RHEA:34515	skos:prefLabel	"undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase"
RHEA:34515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase"
GO:0102115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan asparagine synthase activity
REACT:R-HSA-177107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion and activation of the latent large complex of TGF-beta-1 (Homo sapiens)
REACT:R-BTA-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Bos taurus)
RHEA:65314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP] => an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP]
RHEA:17726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2-methylcitrate => 2-methyl-cis-aconitate + H2O
RHEA:43887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + NAD(+) <=> 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH
RHEA:70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + sphing-4-enine = 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine
REACT:R-BTA-1889978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALT6 transfers Gal to the tetrasaccharide linker (Bos taurus)
REACT:R-CEL-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Caenorhabditis elegans)
RHEA:14424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-benzoyl-D-arginine-4-nitroanilide <=> 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine
RHEA:15981	skos:altLabel	"S-adenosyl-L-methionine decarboxylase"
RHEA:15981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine
RHEA:15981	skos:altLabel	"S-adenosyl-L-methionine carboxy-lyase"
RHEA:15981	skos:prefLabel	"adenosylmethionine decarboxylase"
RHEA:15981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylmethionine decarboxylase"
RHEA:29848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA => (3Z)-tetradecenoyl-CoA
RHEA:34397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-beta-phenylalanine => L-phenylalanine
REACT:R-DDI-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Dictyostelium discoideum)
RHEA:41471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]
RHEA:43544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tyramine = ADP + gamma-L-glutamyltyramine + H(+) + phosphate
RHEA:43544	skos:prefLabel	"tyramine--L-glutamate ligase"
RHEA:43544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyramine--L-glutamate ligase"
RHEA:60862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine
GO:0050171	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:phenol beta-D-glucosyltransferase activity
GO:0050171	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenol-beta-D-glucosyltransferase activity
GO:0050171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenol beta-glucosyltransferase activity
GO:0050171	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose glucosyltransferase activity
GO:0050171	skos:prefLabel	"phenol beta-glucosyltransferase"
GO:0050171	skos:altLabel	"UDP-glucosyltransferase"
GO:0050171	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucosyltransferase activity
GO:0050171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenol b-glucosyltransferase activity
GO:0050171	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucosyltransferase activity
GO:0050171	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:phenol beta-D-glucosyltransferase activity
GO:0050171	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucosyltransferase activity
GO:0050171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenol beta-glucosyltransferase"
RHEA:24938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + imidazol-4-one <=> N-formimidoylglycine
REACT:R-RNO-9021596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane estrogen receptors bind SRC (Rattus norvegicus)
REACT:R-HSA-9028328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to activated NTRK2 recruits GRB2:SOS1 (Homo sapiens)
REACT:R-HSA-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Homo sapiens)
REACT:R-HSA-9706399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 hydrolyzes ATP (Homo sapiens)
REACT:R-GGA-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Gallus gallus)
REACT:R-DRE-169905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS is phosphorylated by active TrkA receptor (Danio rerio)
REACT:R-DRE-9014433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GEFs activate RHOG (Danio rerio)
RHEA:46820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:43679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-XTR-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Xenopus tropicalis)
RHEA:29800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-allose(out) + H2O => ADP + D-allose(in) + H(+) + phosphate
REACT:R-RNO-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Rattus norvegicus)
REACT:R-SSC-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Sus scrofa)
REACT:R-HSA-990478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-14 is a dimer (Homo sapiens)
REACT:R-MMU-1497853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Mus musculus)
RHEA:70950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan(in) <=> L-tryptophan(out)
REACT:R-DRE-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Danio rerio)
REACT:R-DRE-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Danio rerio)
RHEA:52586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => chenodeoxycholoyl-CoA + NAD(+)
RHEA:18960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-isoleucine(out) + 2 Na(+)(out) => chloride(in) + L-isoleucine(in) + 2 Na(+)(in)
RHEA:49591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythrulose 1-phosphate <=> D-erythrulose 4-phosphate
REACT:R-HSA-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)
REACT:R-DME-2022887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 N-deacetylates GlcNAc residues in heparan (Drosophila melanogaster)
REACT:R-HSA-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)
EC:1.1.1.175	skos:altLabel	"NAD-D-xylose dehydrogenase"
EC:1.1.1.175	skos:altLabel	"D-xylose dehydrogenase"
EC:1.1.1.175	skos:prefLabel	"D-xylose 1-dehydrogenase"
EC:1.1.1.175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-xylose 1-dehydrogenase"
EC:1.1.1.175	skos:altLabel	"NAD-linked D-xylose dehydrogenase"
RHEA:48051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E))
REACT:R-MMU-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Mus musculus)
RHEA:39605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA
RHEA:24452	skos:altLabel	"methyl-accepting chemotaxis protein O-methyltransferase"
RHEA:24452	skos:prefLabel	"protein-glutamate O-methyltransferase"
RHEA:24452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-glutamate O-methyltransferase"
RHEA:24452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine
RHEA:23826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + H(+) + NADH => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+)
REACT:R-DME-6814674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Drosophila melanogaster)
REACT:R-DRE-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Danio rerio)
RHEA:10900	skos:prefLabel	"aromatic-amino-acid--glyoxylate transaminase"
RHEA:10900	skos:altLabel	"aromatic-amino-acid--glyoxylate aminotransferase"
RHEA:10900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aromatic-amino-acid--glyoxylate transaminase"
RHEA:10900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic L-alpha-amino acid + glyoxylate = an aromatic oxo-acid + glycine
GO:0005304	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leucine/isoleucine/valine porter activity
GO:0005304	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	valine/tyrosine/tryptophan permease activity
GO:0005304	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	isoleucine/valine:sodium symporter activity
GO:0005304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine transmembrane transporter activity
GO:0005304	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leucine/valine/isoleucine permease activity
GO:0005304	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-valine transporter activity
REACT:R-SSC-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-XTR-5649764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)
RHEA:25256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-mannosamine <=> ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate
REACT:R-DRE-9626832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Danio rerio)
RHEA:21706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + phenol + pyruvate => H2O + L-tyrosine
REACT:R-MMU-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Mus musculus)
RHEA:68772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = diphosphate + germacrene C
GO:0097747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase activity
REACT:R-MMU-8848864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARAP1 (Mus musculus)
REACT:R-RNO-2179274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD3 phosphorylated in the linker region (Rattus norvegicus)
REACT:R-MMU-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Mus musculus)
REACT:R-DRE-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Danio rerio)
GO:0004675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	receptor protein serine/threonine kinase activity
GO:0004675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	receptor serine/threonine protein kinase activity
GO:0004675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor protein serine/threonine kinase activity
RHEA:35592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + n sulfur => H(+) + hydrogen sulfide + (n-1) sulfur
GO:0120226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-coenzyme A binding
GO:0120226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA binding
REACT:R-DDI-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Dictyostelium discoideum)
REACT:R-DRE-8848774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds DOK1 (Danio rerio)
REACT:R-XTR-5432814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR2:TLR1 (Xenopus tropicalis)
REACT:R-DRE-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Danio rerio)
REACT:R-DRE-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Danio rerio)
RHEA:12891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + H(+) + NADH => L-gulonate + NAD(+)
REACT:R-DME-2162226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Drosophila melanogaster)
REACT:R-BTA-83582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Bos taurus)
REACT:R-BTA-8854302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D7 binds the TSC1-TSC2 complex (Bos taurus)
RHEA:67576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine
RHEA:64814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + S-(2-acetamidoethyl)-homocysteine => acetyl-CoA + S-(2-aminoethyl)-homocysteine
RHEA:34381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose
RHEA:60808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A19 + H(+) + O2 = CO2 + gibberellin A20 + H2O
REACT:R-MMU-193460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Mus musculus)
REACT:R-CEL-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Caenorhabditis elegans)
RHEA:57463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP
GO:0043957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acryloyl-CoA reductase (NADPH) activity
GO:0043957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetyl-coenzyme A synthetase/GroES-like domain
GO:0043957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylyl-CoA reductase (NADPH) activity
GO:0043957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	AMP-dependent synthetase and ligase
GO:0043957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetyl-coenzyme A synthetase
GO:0043957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	enoyl-CoA hydratase/isomerase
GO:0043957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acryloyl-CoA reductase (NADP+) activity
GO:0043957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase
RHEA:24267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate + formaldehyde <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone
GO:0140612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA damage sensor activity
GO:0140612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA damage sensing activity
REACT:R-GGA-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Gallus gallus)
REACT:R-DRE-428888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ROBO1 by ABL kinase (Danio rerio)
RHEA:18238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxybenzoate + O2 => 3-maleylpyruvate + H(+)
REACT:R-XTR-3232162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates MITF with SUMO1 (Xenopus tropicalis)
REACT:R-HSA-113446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of RNA Polymerase III Productive Transcription (Homo sapiens)
RHEA:72978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 indole-3-pyruvate <=> 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)
RHEA:68641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => diphosphate + limonene
RHEA:46465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0043860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cphA
GO:0043860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanophycin synthetase activity
RHEA:47350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic alcohol + butanoate + H(+) => a butanoate ester + H2O
REACT:R-HSA-1475025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Homo sapiens)
RHEA:47876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b + H2O = ganglioside GM1 + N-acetylneuraminate
REACT:R-GGA-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Gallus gallus)
REACT:R-RNO-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)
RHEA:24082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp) => ATP + L-tryptophan + tRNA(Trp)
REACT:R-XTR-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Xenopus tropicalis)
REACT:R-SPO-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Schizosaccharomyces pombe)
REACT:R-BTA-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Bos taurus)
RHEA:43440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + sphinganine = H2O + N-hexadecanoylsphinganine
REACT:R-SPO-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Schizosaccharomyces pombe)
REACT:R-BTA-9679477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFA inhibitors (Bos taurus)
REACT:R-DME-110437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DILP binds to Drosophila insulin receptor (DINR) (Drosophila melanogaster)
REACT:R-SSC-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Sus scrofa)
REACT:R-HSA-8876210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	InlB promotes MET dimerization (Homo sapiens)
GO:0102825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-O-rhamnoside-glucosyltransferase activity
REACT:R-SSC-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Sus scrofa)
RHEA:50584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH
REACT:R-RNO-182988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty lures CBL away from EGFR (Rattus norvegicus)
RHEA:41268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoate + sphing-4-enine
RHEA:35581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A11 + D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8
REACT:R-HSA-9709883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB scavenges O2.- (Homo sapiens)
REACT:R-MMU-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Mus musculus)
RHEA:44566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-decaprenyl diphosphate
REACT:R-RNO-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
REACT:R-DRE-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Danio rerio)
REACT:R-GGA-981728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to membrane-associated C3b (Gallus gallus)
GO:0047990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)
GO:0047990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-L-glutamate 1-carboxy-lyase activity
GO:0047990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyglutamate decarboxylase activity
RHEA:21617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)
RHEA:72837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + U[3'-5']pAp[3'] => 3',3'-cUAMP + H2O
RHEA:54845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexan-3-one + NADPH + O2 => ethyl butanoate + H2O + NADP(+)
REACT:R-DME-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Drosophila melanogaster)
RHEA:68788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate
REACT:R-HSA-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Homo sapiens)
REACT:R-RNO-9017817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-secretase cleaves YBX1:NOTCH3 (Rattus norvegicus)
REACT:R-GGA-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
REACT:R-GGA-2671885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers:H+ transport extracellular Na+ to cytosol (Gallus gallus)
REACT:R-RNO-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)
REACT:R-SSC-5684275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
RHEA:34406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-10'-apo-beta-carotenal + 2 O2 <=> (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone
REACT:R-HSA-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Homo sapiens)
RHEA:32790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-ectoine(out) <=> ADP + H(+) + L-ectoine(in) + phosphate
RHEA:56146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + nitrite => a quinol + nitrate
REACT:R-BTA-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Bos taurus)
REACT:R-HSA-205008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF binds to p62 (Sequestosome) (Homo sapiens)
RHEA:28611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XTP => diphosphate + H(+) + XMP
RHEA:64718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + H(+) + NADPH => NADP(+) + propanal
REACT:R-HSA-213175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 oxidise AFB1 to AFXBO (Homo sapiens)
REACT:R-CFA-514604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Canis familiaris)
REACT:R-HSA-8941411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSCN- reacts with Cys residues (Homo sapiens)
RHEA:11888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH
RHEA:30383	skos:prefLabel	"7-epi-alpha-selinene synthase"
RHEA:30383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-7-epi-alpha-selinene + diphosphate
RHEA:30383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-epi-alpha-selinene synthase"
REACT:R-PFA-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Plasmodium falciparum)
RHEA:70791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-ornithine(out) = H(+)(out) + L-ornithine(in)
RHEA:30322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)
REACT:R-CFA-482770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet secretory granule components (Canis familiaris)
REACT:R-CEL-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Caenorhabditis elegans)
RHEA:50803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin A2 <=> prostaglandin A2-S-(S)-glutathione
REACT:R-RNO-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Rattus norvegicus)
RHEA:69400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)2-lipid A + holo-[ACP]
RHEA:28051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) => NAD(+) + phosphate
REACT:R-SSC-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Sus scrofa)
REACT:R-XTR-158722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Xenopus tropicalis)
REACT:R-DRE-6800380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAP-1 (Danio rerio)
REACT:R-SCE-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Saccharomyces cerevisiae)
EC:3.1.3.91	skos:prefLabel	"7-methylguanosine nucleotidase"
EC:3.1.3.91	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-methylguanosine nucleotidase"
EC:3.1.3.91	skos:altLabel	"N(7)-methylguanylate 5'-phosphatase"
REACT:R-SCE-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Saccharomyces cerevisiae)
REACT:R-SSC-450358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Sus scrofa)
REACT:R-XTR-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Xenopus tropicalis)
REACT:R-HSA-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Homo sapiens)
RHEA:20666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-glucitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH
REACT:R-GGA-914036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Gallus gallus)
REACT:R-CFA-9025996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Canis familiaris)
GO:0033977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-haloacid dehalogenase (configuration-retaining) activity
GO:0033977	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-haloalkanoic acid dehalogenase activity
GO:0033977	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DL-2-haloacid dehalogenase activity
GO:0033977	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-haloalkanoid acid halidohydrolase activity
GO:0033977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DL-DEXr
REACT:R-DME-3000335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Drosophila melanogaster)
RHEA:41396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
REACT:R-BTA-71541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Bos taurus)
RHEA:52552	skos:prefLabel	"3-dehydrotetronate 4-kinase"
RHEA:52552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydrotetronate 4-kinase"
RHEA:52552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-D-erythronate + ATP = 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)
RHEA:52552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-erythronate + ATP = 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)
REACT:R-RNO-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Rattus norvegicus)
RHEA:26261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopimara-7,15-dienal + NADP(+) = 2 H(+) + isopimarate + NADPH
REACT:R-BTA-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Bos taurus)
RHEA:69713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + N-hexadecanoylsphinganine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O
REACT:R-HSA-9617535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated calmodulin binds ADCY1,ADCY8 (Homo sapiens)
REACT:R-SSC-975903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Sus scrofa)
REACT:R-CEL-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Caenorhabditis elegans)
RHEA:55306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate
REACT:R-CFA-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Canis familiaris)
RHEA:47051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + shikimate <=> 3-dehydroshikimate + a quinol
RHEA:60891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)
REACT:R-XTR-2454113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 transports 11cRAL to rod photoreceptor outer segment (Xenopus tropicalis)
REACT:R-HSA-112342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of MAP2K1 by CDK1 (Homo sapiens)
RHEA:57203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + L-arginyl-[protein] <=> N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]
RHEA:56431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:10439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O
REACT:R-BTA-5694445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH1 binds TFGA and AREG precursors (Bos taurus)
RHEA:25797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamate
GO:0008977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prephenate:NAD+ oxidoreductase (decarboxylating)
GO:0008977	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxyphenylpyruvate synthase activity
GO:0008977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chorismate mutase--prephenate dehydrogenase activity
GO:0008977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prephenate dehydrogenase (NAD+) activity
REACT:R-SSC-8934819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Sus scrofa)
GO:0031013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	troponin I binding
REACT:R-DME-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Drosophila melanogaster)
REACT:R-DDI-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Dictyostelium discoideum)
REACT:R-CFA-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Canis familiaris)
REACT:R-MMU-70577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Mus musculus)
REACT:R-HSA-3451147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 HAT complex acetylates TCF4 gene at histone H4 (Homo sapiens)
RHEA:41798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine
RHEA:56476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
REACT:R-SCE-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Saccharomyces cerevisiae)
REACT:R-DRE-2161613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Danio rerio)
RHEA:43861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)
REACT:R-CFA-1604368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of bound proMMP2 (Canis familiaris)
REACT:R-MMU-9654521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin dissociates KRAS4B from the plasma membrane (Mus musculus)
RHEA:42018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH => cortisone + NAD(+)
REACT:R-RNO-177924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)
RHEA:52787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfenohercynine + AH2 + H(+) <=> A + ergothioneine + H2O
RHEA:47243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-MMU-8944266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XI (Mus musculus)
RHEA:14092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + glycine <=> glyoxylate + L-glutamate
REACT:R-GGA-5654628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS3 (Gallus gallus)
GO:0035650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-1 adaptor complex binding
REACT:R-BTA-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Bos taurus)
REACT:R-BTA-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Bos taurus)
RHEA:54284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-octadecanoylsphing-4-enine + phosphocholine
GO:0102593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose: N-methylanthranilate glucosyltransferase activity
RHEA:60807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A19 + O2 <=> CO2 + gibberellin A17 + H(+) + succinate
RHEA:30983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]
REACT:R-HSA-480204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)
GO:0042020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-23R
GO:0042020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-23 receptor activity
GO:0042020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-23 receptor activity
REACT:R-SSC-5578742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO1,2:small RNA complexes interact with chromatin (Sus scrofa)
REACT:R-HSA-3928644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB binds ITSN1 (Homo sapiens)
REACT:R-RNO-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Rattus norvegicus)
REACT:R-SSC-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Sus scrofa)
RHEA:13034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galactose 6-phosphate => keto-D-tagatose 6-phosphate
REACT:R-MMU-5672027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Mus musculus)
REACT:R-MMU-169904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3G stimulates nucleotide exchange on Rap1 (Mus musculus)
REACT:R-DME-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Drosophila melanogaster)
RHEA:14966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl phosphate + H2O => a carboxylate + H(+) + phosphate
GO:0018610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzofuran 4,4a-dioxygenase activity
REACT:R-DDI-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Dictyostelium discoideum)
RHEA:35068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine(out) => (S)-carnitine(in)
REACT:R-MMU-114542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1,RAC2,RHOG activate PI3K (Mus musculus)
RHEA:29672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) => Ca(2+)(out)
REACT:R-RNO-400183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA:RXRA binds Corepressors of PPARA (Rattus norvegicus)
RHEA:65000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[ACP] + octanoyl-AMP = AMP + H(+) + octanoyl-[ACP]
RHEA:68517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => beta-acoradiene + diphosphate
REACT:R-DME-350467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUG binds to FT (Drosophila melanogaster)
REACT:R-GGA-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Gallus gallus)
RHEA:40056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trioctanoylglycerol + H2O => 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate
REACT:R-DRE-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Danio rerio)
RHEA:48867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropan-1-amine + FADH2 + O2 <=> FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine
RHEA:27317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 <=> 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)
REACT:R-RNO-390835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD1,5 bind DA (Rattus norvegicus)
REACT:R-SPO-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Schizosaccharomyces pombe)
RHEA:64494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrocitreoisocoumarin + H2O + holo-[ACP] => 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP]
RHEA:68364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)
RHEA:49913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)
GO:0036127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine sulfinate binding
GO:0036127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine binding
GO:0004457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate dehydrogenase activity
GO:0047849	skos:altLabel	"sucrose 6-glucosyltransferase"
GO:0047849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CEP
GO:0047849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dextransucrase activity
GO:0047849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dextransucrase"
GO:0047849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity
GO:0047849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose-1,6-alpha-glucan glucosyltransferase activity
GO:0047849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SGE
GO:0047849	skos:prefLabel	"dextransucrase"
GO:0047849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose 6-glucosyltransferase activity
RHEA:25204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + formaldehyde <=> D-arabino-hex-3-ulose 6-phosphate
RHEA:30869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + 2 H(+) + NADH => H2O + indole-3-acetaldehyde + NAD(+)
REACT:R-HSA-265301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticotropin cleavage from POMC (Homo sapiens)
REACT:R-CFA-5607721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NIK (Canis familiaris)
RHEA:42747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-DME-5618110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Drosophila melanogaster)
REACT:R-MMU-2632521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Mus musculus)
REACT:R-GGA-419003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Nectins with Afadin (Gallus gallus)
REACT:R-RNO-388596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanocortin receptors bind melanocortins (Rattus norvegicus)
RHEA:51805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyhumulone + dimethylallyl diphosphate => diphosphate + H(+) + lupulone
REACT:R-CFA-9707051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN1 binds BRCA1:BARD1 heterodimer (Canis familiaris)
REACT:R-HSA-164617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of Extended Telomeric Chromosome End (Homo sapiens)
RHEA:14515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate => ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine
RHEA:67071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chermesin D methyl ester <=> A + asnovolin J
REACT:R-DDI-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Dictyostelium discoideum)
REACT:R-DME-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)
RHEA:52300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-5687465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds RBBP8 (Xenopus tropicalis)
RHEA:66548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 4-nitrophenol = 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate
REACT:R-CEL-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
RHEA:48283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 + UDP-alpha-D-galactose <=> ganglioside GM1 + H(+) + UDP
RHEA:67422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+) => a glycerophospholipid + H2O
REACT:R-SSC-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Sus scrofa)
REACT:R-XTR-2142859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growing HA is extruded from the cell by ABCC5 (Xenopus tropicalis)
REACT:R-BTA-349603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Bos taurus)
REACT:R-RNO-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Rattus norvegicus)
REACT:R-GGA-9634169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 and NDC1 bind the Nup93 complex (Gallus gallus)
REACT:R-PFA-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Plasmodium falciparum)
RHEA:57180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + methylglyoxal = N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]
REACT:R-HSA-6805399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAF1 phosphorylates TP53 (Homo sapiens)
REACT:R-CFA-2214324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII dimerization (Canis familiaris)
EC:1.7.6.-	skos:prefLabel	"With a nitrogenous group as acceptor"
EC:1.7.6.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a nitrogenous group as acceptor"
REACT:R-HSA-8864343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD1 binds TFAP2 homo- and heterodimers (Homo sapiens)
REACT:R-MMU-442273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV1 is a GEF for Rho/Rac family GTPases (Mus musculus)
REACT:R-GGA-5668947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates myosin phosphatase (Gallus gallus)
REACT:R-MMU-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Mus musculus)
REACT:R-DDI-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)
RHEA:15188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + succinyl-CoA <=> CoA + H(+) + N(2)-succinyl-L-arginine
GO:0004385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-GMP kinase activity
GO:0004385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:GMP phosphotransferase activity
GO:0004385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyguanylate kinase activity
GO:0004385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanylate kinase activity
GO:0004385	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	membrane-associated guanylate kinase
GO:0004385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine monophosphate kinase activity
GO:0004385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GMP kinase activity
GO:0004385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:(d)GMP phosphotransferase activity
GO:0102928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-solanine rhamnosyltransferase activity
REACT:R-DRE-5682709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI4 binds ADAM22,23,11 (Danio rerio)
RHEA:67531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-octenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine
REACT:R-CEL-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Caenorhabditis elegans)
REACT:R-HSA-182263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of MHC I Complex (Homo sapiens)
RHEA:54247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-SSC-211881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A13 (Sus scrofa)
REACT:R-SSC-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Sus scrofa)
RHEA:50669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)
RHEA:48210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein]
REACT:R-CFA-6808496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
REACT:R-CEL-9749583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Caenorhabditis elegans)
REACT:R-BTA-2404137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)
RHEA:55980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated acyl-CoA + an acyl-CoA + H2O = an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)
RHEA:55980	skos:prefLabel	"acyl-CoA:acyl-CoA alkyltransferase"
RHEA:55980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA:acyl-CoA alkyltransferase"
REACT:R-DRE-450463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Danio rerio)
REACT:R-SSC-8868659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)
REACT:R-DDI-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Dictyostelium discoideum)
RHEA:55973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ethanol => CoA + ethyl acetate
EC:3.1.6.19	skos:altLabel	"(R)-specific sec-alkylsulfatase"
EC:3.1.6.19	skos:prefLabel	"(R)-specific secondary-alkylsulfatase (type III)"
EC:3.1.6.19	skos:altLabel	"(R)-specific secondary-alkylsulfatase"
EC:3.1.6.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-specific secondary-alkylsulfatase (type III)"
EC:3.1.6.19	skos:altLabel	"sec-alkylsulfatase"
REACT:R-CFA-3108203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO2,3 (Canis familiaris)
RHEA:46596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + rifampicin = 2'-N-hydroxyrifampicin + H2O + NADP(+)
RHEA:39864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-SPO-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Schizosaccharomyces pombe)
REACT:R-BTA-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Bos taurus)
REACT:R-HSA-6798624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNF420 binds TP53AIP1 gene (Homo sapiens)
REACT:R-SSC-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Sus scrofa)
REACT:R-MMU-8876312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Mus musculus)
RHEA:41449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-isoleucine + O2 => (4S)-4-hydroxy-L-isoleucine + CO2 + succinate
RHEA:54491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-5693608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial resection of double-strand break ends (Xenopus tropicalis)
RHEA:57532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-RNA + ATP + H(+) = a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate
RHEA:57084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)
RHEA:19952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate <=> 7,8-dihydropteroate + diphosphate
REACT:R-XTR-5578742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO1,2:small RNA complexes interact with chromatin (Xenopus tropicalis)
RHEA:35458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 <=> (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)
REACT:R-GGA-140777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Gallus gallus)
REACT:R-BTA-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Bos taurus)
RHEA:71658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O <=> a thymidine in DNA + ADP-D-ribose
REACT:R-MMU-9698170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Mus musculus)
REACT:R-MMU-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)
RHEA:41149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O
RHEA:56277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-proline => 3'-L-prolyl-AMP + diphosphate
REACT:R-MMU-205262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Direct recruitment of PI3K to p-KIT (Mus musculus)
REACT:R-CFA-211239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with chromatin (Canis familiaris)
RHEA:30141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + octadecanoate => H2O + octadecanoyl-CoA
REACT:R-CFA-388981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Kiss receptor GPR54 binds kisspeptin (Canis familiaris)
REACT:R-HSA-2167924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7:SMURF1 complex binds XPO1 (CRM1) (Homo sapiens)
RHEA:12203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + 2-oxoglutarate + O2 <=> CO2 + mugineate + succinate
REACT:R-BTA-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
RHEA:62856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-RNO-5218819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
RHEA:53072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:22952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octanedioyl-CoA = (2E)-octenedioyl-CoA + H2O2
REACT:R-HSA-918225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
RHEA:23211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + trans-glutaconate <=> (2E)-glutaconyl-CoA + acetate
REACT:R-HSA-5423694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFBDHD hydrolyses non-enzymatically to AFBDHO (Homo sapiens)
REACT:R-XTR-110231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by MBD4 glycosylase (Xenopus tropicalis)
RHEA:26070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + phosphinomethylmalate => 3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O
REACT:R-GGA-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Gallus gallus)
REACT:R-RNO-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Rattus norvegicus)
REACT:R-XTR-392054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Xenopus tropicalis)
REACT:R-HSA-3134821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PK binds microbial dsDNA (Homo sapiens)
REACT:R-XTR-191972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol is 7alpha-hydroxylated (Xenopus tropicalis)
REACT:R-HSA-9626256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8:LAMP2a multimers depolymerizes to monomers (Homo sapiens)
REACT:R-CEL-2533950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP14, TMPRSS6 (Caenorhabditis elegans)
REACT:R-GGA-5690250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Gallus gallus)
REACT:R-DDI-76397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Dictyostelium discoideum)
REACT:R-BTA-426522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nonendonucleolytic RISC binds exactly matching target RNAs (Bos taurus)
GO:0030625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U11 snRNA binding
REACT:R-MMU-1306953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
RHEA:28071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o
REACT:R-HSA-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
REACT:R-HSA-8987132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Homo sapiens)
REACT:R-CFA-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Canis familiaris)
REACT:R-GGA-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Gallus gallus)
REACT:R-SCE-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Saccharomyces cerevisiae)
REACT:R-MMU-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Mus musculus)
RHEA:16470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-benzylsuccinate + succinyl-CoA => (R)-2-benzylsuccinyl-CoA + succinate
REACT:R-DME-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Drosophila melanogaster)
RHEA:18676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-seryl-[receptor-protein]
RHEA:11158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+) => H2O + L-valine + NADP(+)
REACT:R-HSA-9018901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2 (Homo sapiens)
REACT:R-MMU-5688837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 deubiquitinates polyUb-PARK2 (Mus musculus)
REACT:R-CFA-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Canis familiaris)
REACT:R-CFA-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Canis familiaris)
REACT:R-XTR-870538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Xenopus tropicalis)
RHEA:32886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinic aldehyde + NADP(+) <=> (+)-artemisinic aldehyde + H(+) + NADPH
GO:0047745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorogenate hydrolase activity
GO:0047745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorogenase activity
GO:0047745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorogenic acid esterase activity
REACT:R-DRE-201640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Danio rerio)
REACT:R-CFA-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Canis familiaris)
REACT:R-DME-8964604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Drosophila melanogaster)
REACT:R-HSA-6784399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Homo sapiens)
RHEA:44217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoate + ATP + CoA => 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate
REACT:R-GGA-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Gallus gallus)
RHEA:23520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + propanoate = acetate + propanoyl-CoA
RHEA:23520	skos:prefLabel	"propionate CoA-transferase"
RHEA:23520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"propionate CoA-transferase"
EC:4.2.2.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gellan lyase"
EC:4.2.2.25	skos:prefLabel	"gellan lyase"
REACT:R-RNO-193981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 oxidises 17HPROG (Rattus norvegicus)
REACT:R-SPO-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-SSC-5591052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROCR binds Protein C (Sus scrofa)
REACT:R-HSA-8874083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y397-PTK2 binds SRC (Homo sapiens)
REACT:R-CEL-2393954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)
GO:0047407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity
GO:0047407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dinitrogenase reductase activating glycohydrolase activity
GO:0047407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-ribosyl glycohydrolase activity
GO:0047407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	azoferredoxin glycosidase activity
GO:0047407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-ribosyl-[dinitrogen reductase] hydrolase activity
GO:0047407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-ribosyl-dinitrogen reductase hydrolase activity
GO:0047407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dinitrogenase reductase-activating glycohydrolase activity
GO:0047407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	azoferredoxin-activating enzymes
RHEA:27520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sphing-4-enine => H2O + sphing-4-enine 1-phosphate
RHEA:30190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + a quinone <=> a quinol + orotate
REACT:R-MMU-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Mus musculus)
RHEA:46005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanal + CoA + NAD(+) => 2-methylpropanoyl-CoA + H(+) + NADH
RHEA:50290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2
RHEA:16930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 benzoyl-CoA + L-ornithine => 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine
RHEA:64571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one <=> ilicicolin H
RHEA:67100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumigatonoid B = fumigatonoid C
REACT:R-CFA-163320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of mTERF with the termination sequence (Canis familiaris)
GO:0047612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl coenzyme A synthetase (guanosine diphosphate forming)
GO:0047612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acid-CoA ligase (GDP-forming) activity
GO:0047612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA synthetase (GDP-forming) activity
GO:0047612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid:CoA ligase (GDP-forming)
RHEA:50153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O
RHEA:21819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)
REACT:R-GGA-8948234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB:4-Hyp collagen propeptides dissociates (Gallus gallus)
REACT:R-CFA-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
RHEA:21439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[translation elongation factor 2] + ATP <=> [translation elongation factor 2]-phosphate + ADP + H(+)
RHEA:68106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone => all-trans-zeaxanthin + O2
RHEA:56913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) => (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH
RHEA:40142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H2O <=> (9Z)-octadecenoate + CoA + H(+)
RHEA:47080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyestr-4-en-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-estran-3-one + NADP(+)
REACT:R-HSA-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)
REACT:R-BTA-5668414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)
REACT:R-GGA-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Gallus gallus)
REACT:R-CFA-9706328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS2 (Canis familiaris)
REACT:R-CFA-3907292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Canis familiaris)
RHEA:66832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + preasperterpenoid A
REACT:R-MMU-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Mus musculus)
RHEA:65236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol + acetyl-CoA = 3-methylbutyl acetate + CoA
RHEA:25186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dichloroethane + H2O => 2-chloroethanol + chloride + H(+)
RHEA:32017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-MMU-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Mus musculus)
RHEA:42735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(527) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:50854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2
REACT:R-CFA-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Canis familiaris)
RHEA:21923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP
RHEA:22152	skos:prefLabel	"quinoprotein glucose dehydrogenase (PQQ, quinone)"
RHEA:22152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinoprotein glucose dehydrogenase (PQQ, quinone)"
RHEA:22152	skos:altLabel	"glucose dehydrogenase (pyrroloquinoline-quinone)"
RHEA:22152	skos:altLabel	"D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase"
RHEA:22152	skos:altLabel	"glucose dehydrogenase (PQQ-dependent)"
RHEA:22152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + D-glucose = a ubiquinol + D-glucono-1,5-lactone
RHEA:22152	skos:altLabel	"quinoprotein D-glucose dehydrogenase"
REACT:R-RNO-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Rattus norvegicus)
REACT:R-HSA-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Homo sapiens)
REACT:R-SPO-194718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Schizosaccharomyces pombe)
RHEA:34336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-192422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular PTL:colipase (Rattus norvegicus)
REACT:R-SCE-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Saccharomyces cerevisiae)
REACT:R-MMU-2065357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)
REACT:R-SPO-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Schizosaccharomyces pombe)
RHEA:22866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine => L-lysine
RHEA:65389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP
REACT:R-HSA-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Homo sapiens)
REACT:R-BTA-1247922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCT transforms gGluCys to OPRO (Bos taurus)
RHEA:19730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + H(+) => acetone + CO2
RHEA:43655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + CoA
RHEA:35706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-hydroxyversicolorone + H(+) + NADPH + O2 <=> (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)
GO:0050511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity
GO:0050511	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity
GO:0050511	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity
GO:0050511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
GO:0050511	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MurG transferase activity
GO:0050511	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity
REACT:R-CEL-192335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Caenorhabditis elegans)
REACT:R-GGA-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Gallus gallus)
REACT:R-DRE-9708104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE5A dimer binds PDE5A inhibitors (Danio rerio)
RHEA:62137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + GTP => dGDP + GDP
REACT:R-SCE-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Saccharomyces cerevisiae)
REACT:R-MMU-74743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-Y427-SHC1 from insulin receptor (Mus musculus)
RHEA:71176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) => 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)
RHEA:65369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
RHEA:39242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-triacontenoyl-CoA + H(+) + NADPH <=> NADP(+) + triacontanoyl-CoA
REACT:R-SSC-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Sus scrofa)
REACT:R-HSA-452122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Homo sapiens)
REACT:R-HSA-193101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11A1 cleaves 20a,22b-DHCHOL (Homo sapiens)
RHEA:62554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP => beta-D-glucosylceramide + UDP-alpha-D-galactose
REACT:R-SSC-981535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) binds C3bBb, C4bC2a (Sus scrofa)
REACT:R-DDI-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Dictyostelium discoideum)
RHEA:49007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADPH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)
REACT:R-CFA-5665809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)
RHEA:22724	skos:prefLabel	"sterol 3beta-glucosyltransferase"
RHEA:22724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP
RHEA:22724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sterol 3beta-glucosyltransferase"
RHEA:34618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + O2 <=> H(+) + hydrogencarbonate + methylphosphonate
REACT:R-DRE-5687673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN recruits LIG3:XRCC1 to MMEJ sites (Danio rerio)
REACT:R-SSC-9027275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Sus scrofa)
REACT:R-DME-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Drosophila melanogaster)
REACT:R-MMU-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Mus musculus)
GO:0047521	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	12beta-hydroxysteroid dehydrogenase activity
GO:0047521	skos:prefLabel	"12beta-hydroxysteroid dehydrogenase"
GO:0047521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity
GO:0047521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH
GO:0047521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"12beta-hydroxysteroid dehydrogenase"
GO:0047521	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	12-beta-hydroxysteroid dehydrogenase activity
GO:0047521	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity
GO:0047521	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
REACT:R-SSC-8964271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in PIP3:BTK:G beta-gamma complex is activated (Sus scrofa)
RHEA:13136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + di-trans,poly-cis-dolichol <=> a dolichyl phosphate + CDP + H(+)
RHEA:48741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate
REACT:R-HSA-8985799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT1 binds ROBO1,(ROBO2) (Homo sapiens)
REACT:R-CFA-9690439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds LTC4,LTD4,LTE4 (Canis familiaris)
RHEA:50315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + H(+) <=> butanal + CO2
REACT:R-DRE-5218812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates PAK2 (Danio rerio)
REACT:R-SSC-388863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Sus scrofa)
RHEA:62076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose 6-phosphate + NAD(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADH
REACT:R-RNO-399936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of integrin activation by sequestering PIP5KIgamma (Rattus norvegicus)
REACT:R-HSA-210773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDX1-dependent synthesis of NR5A2 protein (Homo sapiens)
REACT:R-CEL-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Caenorhabditis elegans)
RHEA:36230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-MMU-3222072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAXX binds Ub-MDM2 and USP7 (Mus musculus)
RHEA:50463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + ATP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + diphosphate
REACT:R-CFA-9731613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)
REACT:R-HSA-168878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis (Homo sapiens)
RHEA:67383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-cysteine <=> L-alanine + L-cysteine
REACT:R-BTA-3364026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SET1 complex trimethylates H3K4 at the MYC gene (Bos taurus)
REACT:R-BTA-390224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Bos taurus)
REACT:R-DME-5654734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Drosophila melanogaster)
REACT:R-CEL-1169405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein phosphatase 1 beta (PP2CB) (Caenorhabditis elegans)
REACT:R-MMU-8864036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates PDGFRB at Y1021 (Mus musculus)
REACT:R-HSA-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Homo sapiens)
REACT:R-XTR-5654607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PPTN11 (Xenopus tropicalis)
GO:0002171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity IgA receptor activity
GO:0002171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity IgA receptor activity
REACT:R-GGA-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Gallus gallus)
REACT:R-DDI-428609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type I Na+-coupled phosphate co-transport (Dictyostelium discoideum)
RHEA:14239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine => 10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-114261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-7 by the apoptosome (Mus musculus)
REACT:R-GGA-9612501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates CREB1 (Gallus gallus)
REACT:R-BTA-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Bos taurus)
RHEA:41425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 => formate + grixazone A + H(+) + 3 H2O
REACT:R-RNO-77312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Rattus norvegicus)
REACT:R-CEL-4724284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Caenorhabditis elegans)
REACT:R-DME-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Drosophila melanogaster)
RHEA:72459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + L-aspartate(out) = fumarate(out) + L-aspartate(in)
REACT:R-CFA-8874718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA binds alpha-TOH (Canis familiaris)
REACT:R-DME-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Drosophila melanogaster)
RHEA:71622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + 2 thiosulfate(out) <=> (S)-malate(out) + 2 thiosulfate(in)
REACT:R-DRE-8953418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 complex binds E2F6.com-1 core (Danio rerio)
RHEA:13618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-methyl-5'-thioadenosine => 5-(methylsulfanyl)-D-ribose + adenine
REACT:R-CEL-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Caenorhabditis elegans)
REACT:R-XTR-1112708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-Y759-IL6ST (Xenopus tropicalis)
GO:0098618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenomethionine-tRNA ligase activity
GO:0098618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)
REACT:R-SPO-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Schizosaccharomyces pombe)
EC:3.7.1.14	skos:prefLabel	"2-hydroxy-6-oxonona-2,4-dienedioate hydrolase"
EC:3.7.1.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-6-oxonona-2,4-dienedioate hydrolase"
RHEA:19298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-histidine => ADP + carnosine + H(+) + phosphate
RHEA:37295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-threonine(out) = ADP + H(+) + L-alanyl-L-threonine(in) + phosphate
REACT:R-DME-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Drosophila melanogaster)
RHEA:45099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Homo sapiens)
REACT:R-RNO-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Rattus norvegicus)
RHEA:47220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-6805059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2:FACT phosphorylates TP53 (Rattus norvegicus)
REACT:R-RNO-139895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAK protein (Rattus norvegicus)
REACT:R-SSC-9706336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SYK (Sus scrofa)
RHEA:10828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + ATP + CoA = AMP + anthraniloyl-CoA + diphosphate
RHEA:10828	skos:prefLabel	"anthranilate--CoA ligase"
RHEA:10828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthranilate--CoA ligase"
RHEA:67924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP
REACT:R-CEL-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Caenorhabditis elegans)
RHEA:43458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA
RHEA:45524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]
RHEA:45524	skos:prefLabel	"C-phycocyanin alpha-cysteine-84 phycocyanobilin lyase"
RHEA:45524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"C-phycocyanin alpha-cysteine-84 phycocyanobilin lyase"
RHEA:53865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH
REACT:R-HSA-9612076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters (Homo sapiens)
REACT:R-SSC-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)
REACT:R-SSC-429663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-DME-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Drosophila melanogaster)
RHEA:54563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP <=> a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)
RHEA:38157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E,10E)-geranyllinalool + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O
RHEA:16547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + oxalyl-CoA => formyl-CoA + oxalate
REACT:R-CEL-5688837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 deubiquitinates polyUb-PARK2 (Caenorhabditis elegans)
REACT:R-HSA-6807875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
REACT:R-RNO-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Rattus norvegicus)
REACT:R-CFA-8853965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Canis familiaris)
RHEA:50068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycoursodeoxycholate(in) + H2O = ADP + glycoursodeoxycholate(out) + H(+) + phosphate
REACT:R-SSC-2029455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIA with IgG-coated Ag (Sus scrofa)
REACT:R-DRE-5654672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR1 (Danio rerio)
RHEA:20497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-arylethylamine + acetyl-CoA = CoA + H(+) + N-acetyl-2-arylethylamine
REACT:R-BTA-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
REACT:R-SPO-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Schizosaccharomyces pombe)
RHEA:39489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA
REACT:R-CEL-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)
REACT:R-HSA-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
REACT:R-CFA-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Canis familiaris)
REACT:R-RNO-5686685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)
RHEA:13055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-alanine => L-phenylalanine + pyruvate
RHEA:11886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cortisol
REACT:R-XTR-9645520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Xenopus tropicalis)
REACT:R-DDI-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Dictyostelium discoideum)
RHEA:27753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
RHEA:20391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+) => (2R,3R)-dihydroquercetin + H(+) + NADPH + O2
RHEA:37417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA
RHEA:56102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate => [small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+)
REACT:R-HSA-5676591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Homo sapiens)
REACT:R-SSC-2426259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Sus scrofa)
REACT:R-RNO-996727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST recruits the BHC complex (Rattus norvegicus)
REACT:R-DRE-9603419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds SRC (Danio rerio)
RHEA:40815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-CEL-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Caenorhabditis elegans)
GO:0043752	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	AdoCbi kinase/AdoCbi-phosphate guanylyltransferase
GO:0043752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTP:adenosylcobinamide phosphotransferase activity
GO:0043752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobU
GO:0043752	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase
GO:0043752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcobinamide kinase activity
RHEA:42393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + NAD(+) => D-galactono-1,5-lactone + H(+) + NADH
RHEA:46130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-9733292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind pramlintide (Canis familiaris)
REACT:R-HSA-3697855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide and nitric oxide react to form peroxynitrite in mitochondria (Homo sapiens)
REACT:R-XTR-5362441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Xenopus tropicalis)
RHEA:58241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => ADP-D-ribose + L-cysteinyl-[protein]
RHEA:13448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantetheine + H2O <=> (R)-pantothenate + cysteamine
GO:0019178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP phosphatase activity
REACT:R-SPO-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Schizosaccharomyces pombe)
RHEA:33317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA
REACT:R-MMU-1638821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
RHEA:69651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O
RHEA:42830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-SSC-6784734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds LDLR (Sus scrofa)
REACT:R-DRE-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Danio rerio)
RHEA:42611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + (n+1) H(+)(in) + NADH <=> a plastoquinol + n H(+)(out) + NAD(+)
REACT:R-HSA-8951676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TEADs and YAP1 (Homo sapiens)
REACT:R-MMU-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Mus musculus)
REACT:R-XTR-203553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS binds NOSIP (Xenopus tropicalis)
REACT:R-DME-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Drosophila melanogaster)
RHEA:36090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine
RHEA:45387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-2029475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of AA by iPLA2 upon FCGR activation (Homo sapiens)
REACT:R-GGA-353243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site. (Gallus gallus)
REACT:R-CEL-9009282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates RUNX2 (Caenorhabditis elegans)
REACT:R-SSC-3769397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOST binds LRP5/6 (Sus scrofa)
REACT:R-HSA-8961991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the TK1 gene promoter (Homo sapiens)
RHEA:24660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine + NADPH + O2 = H2O + N(omega)-hydroxy-L-arginine + NADP(+)
GO:0018761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity
GO:0018761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromoxynil-specific nitrilase activity
GO:0018761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromoxynil nitrilase activity
REACT:R-HSA-9709842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS binds TOMM70 (Homo sapiens)
REACT:R-XTR-159443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)
REACT:R-GGA-187934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Gallus gallus)
REACT:R-DME-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Drosophila melanogaster)
REACT:R-BTA-9757686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDL (Bos taurus)
REACT:R-RNO-1980125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH binds DTX (Rattus norvegicus)
REACT:R-XTR-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Xenopus tropicalis)
RHEA:45778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + NH4(+) => (indol-3-yl)acetonitrile + 2 H2O
RHEA:57300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate
RHEA:28782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-threonine <=> glycine + glycolaldehyde
RHEA:43420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-RNO-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Rattus norvegicus)
REACT:R-CFA-5357429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL autophosphorylates on Y772 and Y814 (Canis familiaris)
REACT:R-HSA-2028284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Homo sapiens)
GO:0019785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISG15-specific protease activity
GO:0019785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISG15-specific peptidase activity
REACT:R-DRE-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Danio rerio)
RHEA:48652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Bos taurus)
RHEA:36827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioscin + 3 H2O = D-glucose + diosgenin + 2 L-rhamnopyranose
RHEA:36827	skos:prefLabel	"dioscin glycosidase (diosgenin-forming)"
RHEA:36827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dioscin glycosidase (diosgenin-forming)"
RHEA:36827	skos:altLabel	"dioscin glycosidase (aglycone-forming)"
RHEA:63756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavokermesate + UDP-alpha-D-glucose = flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP
RHEA:41465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-167072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)
REACT:R-GGA-177942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EGF ligand (Gallus gallus)
REACT:R-SSC-391153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds GRB2-1 (Sus scrofa)
RHEA:35077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	doxorubicin(out) + H(+)(in) => doxorubicin(in) + H(+)(out)
GO:0004913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-4 receptor activity
GO:0004913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-4 receptor activity
GO:0004913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-4R
REACT:R-DDI-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Dictyostelium discoideum)
REACT:R-CEL-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Caenorhabditis elegans)
RHEA:54793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[nsP1 protein]-L-histidine + N(7)-methyl-GTP => [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate
REACT:R-DRE-2024108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some HSPGs are secreted to the plasma membrane (Danio rerio)
RHEA:39876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol
RHEA:38715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + choline(out) + H2O = ADP + choline(in) + H(+) + phosphate
REACT:R-CFA-4088134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates FOXM1 (Canis familiaris)
REACT:R-RNO-8857662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Rattus norvegicus)
REACT:R-CEL-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
REACT:R-RNO-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Rattus norvegicus)
REACT:R-DRE-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Danio rerio)
REACT:R-GGA-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Gallus gallus)
REACT:R-SSC-9706344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates GRB10 (Sus scrofa)
REACT:R-CFA-6807118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)
RHEA:21889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-OPC-8 + NADP(+) => (10Z,15Z)-12-oxophytodienoate + H(+) + NADPH
RHEA:20269	skos:prefLabel	"oligogalacturonide lyase"
RHEA:20269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate
RHEA:20269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligogalacturonide lyase"
RHEA:63872	skos:prefLabel	"L-isoleucine 3(1)-dioxygenase"
RHEA:63872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-isoleucine 3(1)-dioxygenase"
RHEA:63872	skos:altLabel	"L-isoleucine 4'-dioxygenase"
RHEA:63872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-isoleucine + O2 = 3(1)-hydroxy-L-isoleucine + CO2 + succinate
REACT:R-CFA-5653770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)
RHEA:49639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylglyoxal + O2 <=> H(+) + H2O2 + pyruvate
RHEA:41935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoyl-[ACP] <=> H(+) + hexadecanoate + holo-[ACP]
REACT:R-SCE-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-DRE-110356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MPG glycosylase by APEX1 at the AP site (Danio rerio)
REACT:R-DRE-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Danio rerio)
REACT:R-CEL-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Caenorhabditis elegans)
REACT:R-XTR-9653595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B binds BCL2L1 (Xenopus tropicalis)
REACT:R-BTA-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Bos taurus)
REACT:R-DME-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)
RHEA:53883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + D-glucose 6-phosphate <=> ADP + alpha,alpha-trehalose 6-phosphate + H(+)
REACT:R-CFA-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Canis familiaris)
REACT:R-MMU-389941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP-1 and SHP-2 bind pBTLA (Mus musculus)
REACT:R-RNO-114600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Rattus norvegicus)
REACT:R-RNO-5621354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Rattus norvegicus)
RHEA:72674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)
GO:0000182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosomal DNA binding
GO:0000182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rDNA binding
GO:0030107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLA-A specific inhibitory MHC class I receptor activity
RHEA:61548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Canis familiaris)
REACT:R-CFA-8877760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Canis familiaris)
REACT:R-XTR-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Xenopus tropicalis)
REACT:R-CEL-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Caenorhabditis elegans)
REACT:R-DRE-2201341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TRAM (TICAM2) (Danio rerio)
REACT:R-BTA-8956099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Bos taurus)
REACT:R-HSA-164616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Biogenesis and assembly of the telomerase RNP (Homo sapiens)
RHEA:14901	skos:prefLabel	"casbene synthase"
RHEA:14901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"casbene synthase"
RHEA:14901	skos:altLabel	"casbene synthetase"
RHEA:14901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = casbene + diphosphate
RHEA:16517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-aminopropanol dehydrogenase"
RHEA:16517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH
RHEA:16517	skos:prefLabel	"(R)-aminopropanol dehydrogenase"
REACT:R-DRE-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Danio rerio)
REACT:R-CFA-1638032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Canis familiaris)
REACT:R-DRE-9696179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Danio rerio)
GO:0045159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin II binding
REACT:R-RNO-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Rattus norvegicus)
RHEA:51279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate
RHEA:17199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 4-hydroxyphenylacetate + 2 CO2 => 2 3-(4-hydroxyphenyl)pyruvate + O2
RHEA:57887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H2O + Na(+)(in) <=> H(+) + Na(+)(out) + 2 phosphate
REACT:R-DRE-174731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of newly synthesized ApoB-48 (Danio rerio)
REACT:R-XTR-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Xenopus tropicalis)
RHEA:33756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoate
REACT:R-SSC-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Sus scrofa)
REACT:R-SSC-5676597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Sus scrofa)
REACT:R-XTR-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Xenopus tropicalis)
REACT:R-XTR-904830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
RHEA:53499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate
RHEA:38196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Danio rerio)
RHEA:40866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + heptadecanoyl-CoA <=> FADH2 + trans-2-heptadecenoyl-CoA
RHEA:25906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehypoxanthine futalosine + hypoxanthine => futalosine + H2O
GO:0047768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-carboxymuconate cyclase activity
GO:0047768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
GO:0047768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-carboxy-cis,cis-muconate lactonizing enzyme activity
GO:0047768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxy-cis,cis-muconate cyclase activity
RHEA:49610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH => 2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+)
RHEA:53598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycerol + phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + H2O
RHEA:15085	skos:altLabel	"alpha-galactosidase B"
RHEA:15085	skos:prefLabel	"alpha-N-acetylgalactosaminidase"
RHEA:15085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-N-acetylgalactosaminidase"
RHEA:15085	skos:altLabel	"alpha-GalNAcase"
RHEA:15085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine
RHEA:15085	skos:altLabel	"alpha-NAGA"
RHEA:23712	skos:altLabel	"21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate)"
RHEA:23712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"21-hydroxysteroid dehydrogenase (NADP(+))"
RHEA:23712	skos:altLabel	"NADP-21-hydroxysteroid dehydrogenase"
RHEA:23712	skos:altLabel	"21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase"
RHEA:23712	skos:prefLabel	"21-hydroxysteroid dehydrogenase (NADP(+))"
RHEA:23712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al
RHEA:23712	skos:altLabel	"21-hydroxy steroid dehydrogenase"
RHEA:26391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-10'-apo-beta-carotenal + beta-ionone => all-trans-beta-carotene + O2
REACT:R-DRE-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Danio rerio)
REACT:R-BTA-2309787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS2 (Bos taurus)
REACT:R-MMU-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Mus musculus)
GO:0061593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfoquinovose isomerase activity
GO:0140442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxide sensor activity
RHEA:34141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + Delta(9)-tetrahydrocannabinol => Delta(9)-tetrahydrocannabinolate + H(+)
RHEA:51110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-4615905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO1 (Mus musculus)
RHEA:17590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2'-iminodipropanoate + H2O + NAD(+) => H(+) + L-alanine + NADH + pyruvate
RHEA:67432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine
REACT:R-RNO-1181149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Rattus norvegicus)
RHEA:44836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose = globoside NOR2 (d18:1(4E)) + H(+) + UDP
RHEA:68119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol <=> a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol
REACT:R-RNO-8874470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Rattus norvegicus)
GO:0047582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methylene-L-glutamine amidohydrolase activity
GO:0047582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methyleneglutamine deamidase activity
GO:0047582	skos:prefLabel	"4-methyleneglutaminase"
GO:0047582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyleneglutaminase activity
GO:0047582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-methyleneglutaminase"
GO:0047582	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methyleneglutamine amidohydrolase activity
GO:0047582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4(+)
GO:0047582	skos:altLabel	"4-methyleneglutamine deamidase"
RHEA:65133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + preaustinoid A1 => CO2 + H2O + preaustinoid A2 + succinate
RHEA:28183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate => (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate
RHEA:41864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+)
REACT:R-GGA-9708525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1:FBXL17 binds SCF(SKP2) complex (Gallus gallus)
RHEA:66233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IC-asc-C7-CoA + O2 => H2O2 + IC-asc-DeltaC7-CoA
REACT:R-BTA-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Bos taurus)
REACT:R-HSA-5340587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF43 frameshift mutants show enhanced WNT siganling (Homo sapiens)
RHEA:50409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(2-aminophenyl)decane-1,3-dione => 2-heptyl-4(1H)-quinolone + H2O
GO:0050028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alpha-aminocaprolactam hydrolase activity
GO:0050028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine-lactamase activity
GO:0050028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine-1,6-lactam lactamhydrolase activity
GO:0050028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysinamidase activity
REACT:R-MMU-9712210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Mus musculus)
RHEA:22716	skos:altLabel	"cytochrome P450 46A1"
RHEA:22716	skos:prefLabel	"cholesterol 24-hydroxylase"
RHEA:22716	skos:altLabel	"cholesterol 24-monooxygenase"
RHEA:22716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:22716	skos:altLabel	"cholesterol 24S-hydroxylase"
RHEA:22716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholesterol 24-hydroxylase"
RHEA:22716	skos:altLabel	"CYP46A1"
REACT:R-GGA-419461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 (Gallus gallus)
REACT:R-DME-209160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated HOP phosphorylates DOME (Drosophila melanogaster)
REACT:R-HSA-9618785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin binds neurogranin (Homo sapiens)
REACT:R-DME-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Drosophila melanogaster)
REACT:R-CFA-9714483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the ER membrane (Canis familiaris)
REACT:R-SCE-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Saccharomyces cerevisiae)
GO:0038106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choriogonadotropin hormone binding
GO:0038106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorionic gonadotropin binding
GO:0038106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorionic gonadotrophin binding
REACT:R-RNO-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Rattus norvegicus)
RHEA:55531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-tyrosine + O2 <=> (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)
REACT:R-SSC-201472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Sus scrofa)
REACT:R-HSA-9698933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCMV B Nucleocapsid Translocation (Homo sapiens)
REACT:R-XTR-193143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates TEST to EST17b (Xenopus tropicalis)
RHEA:49383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Homo sapiens)
RHEA:13768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromochloromethane + H2O <=> bromide + chloride + formaldehyde + 2 H(+)
REACT:R-SSC-9650473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 is secreted (Sus scrofa)
RHEA:14432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [oligopeptide](in) + ATP + H2O <=> a [oligopeptide](out) + ADP + H(+) + phosphate
REACT:R-BTA-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Bos taurus)
REACT:R-SCE-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)
REACT:R-BTA-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Bos taurus)
REACT:R-GGA-6814094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds ARFIP2 (Gallus gallus)
REACT:R-SCE-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)
RHEA:48282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + H(+) + UDP => ganglioside GM2 + UDP-alpha-D-galactose
RHEA:19217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DDT-dehydrochlorinase"
RHEA:19217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)
RHEA:19217	skos:prefLabel	"DDT-dehydrochlorinase"
REACT:R-CFA-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Canis familiaris)
REACT:R-DRE-109380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Danio rerio)
REACT:R-DRE-110375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Danio rerio)
REACT:R-MMU-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Mus musculus)
REACT:R-BTA-3322431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds TLE (Bos taurus)
REACT:R-SSC-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Sus scrofa)
REACT:R-SSC-9603984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Sus scrofa)
REACT:R-XTR-2534248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP2, MMP3, MMP7 (Xenopus tropicalis)
RHEA:42225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + testosterone => AH2 + androst-4-ene-3,17-dione
RHEA:24559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) <=> 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH
RHEA:19607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a chlorophyllide + H(+) + phytol => a chlorophyll + H2O
REACT:R-DDI-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Dictyostelium discoideum)
REACT:R-DRE-110364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Danio rerio)
RHEA:17556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanidinoethyl methyl phosphate <=> ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate
RHEA:67542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine => (9Z)-hexadecenoyl-CoA + H2O
EC:3.2.2.23	skos:altLabel	"Fapy-DNA glycosylase"
EC:3.2.2.23	skos:prefLabel	"DNA-formamidopyrimidine glycosylase"
EC:3.2.2.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA-formamidopyrimidine glycosylase"
EC:3.2.2.23	skos:altLabel	"formamidopyrimidine-DNA glycosylase"
REACT:R-DRE-9009309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STUB1 (Danio rerio)
RHEA:58998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + indole-3-carboxylate => H2O + indole-3-carbaldehyde + O2
REACT:R-DDI-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Dictyostelium discoideum)
REACT:R-HSA-194121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-RNO-75083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Rattus norvegicus)
RHEA:18717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine
RHEA:18717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylquercetagetin 6-O-methyltransferase"
RHEA:18717	skos:altLabel	"flavonol 6-O-methyltransferase"
RHEA:18717	skos:prefLabel	"methylquercetagetin 6-O-methyltransferase"
RHEA:25974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(8)-acetylspermidine + O2
GO:0052605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol
GO:0052605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol cyclase activity
RHEA:21287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + NAD(+) <=> all-trans-retinal + H(+) + NADH
REACT:R-DME-8850529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGS proteins bind GNB5 and CCT/TRiC (Drosophila melanogaster)
REACT:R-CFA-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Canis familiaris)
RHEA:15664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside <=> an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA
REACT:R-SSC-8983003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Sus scrofa)
REACT:R-RNO-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)
RHEA:21815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + hydroxylamine + NH4(+) => 2 AH2 + H(+) + H2O + N2
REACT:R-CEL-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Caenorhabditis elegans)
REACT:R-DME-8869603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A13 transports NCA from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-HSA-2179276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 monoubiquitinates SMAD3 (Homo sapiens)
REACT:R-MMU-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Mus musculus)
REACT:R-SSC-5637686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)
REACT:R-DRE-1602399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLB1 (Danio rerio)
REACT:R-GGA-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Gallus gallus)
REACT:R-DRE-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Danio rerio)
REACT:R-MMU-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Mus musculus)
RHEA:13708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine <=> alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP
REACT:R-SSC-389759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP-1 or SHP-2 with phospho PD-1 (Sus scrofa)
REACT:R-HSA-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Homo sapiens)
RHEA:60417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diglucosyl-enterobactin + H2O => H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2
REACT:R-SCE-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Saccharomyces cerevisiae)
REACT:R-SSC-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Sus scrofa)
REACT:R-MMU-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Mus musculus)
RHEA:31684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prosolanapyrone III => (-)-solanapyrone A
RHEA:25262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2
RHEA:43853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + triacontanoyl-CoA => 3-oxo-dotriacontanoyl-CoA + CO2 + CoA
REACT:R-SPO-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Schizosaccharomyces pombe)
REACT:R-XTR-8873850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD5 binds DCA, LCA (Xenopus tropicalis)
RHEA:18854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + tartrate => 2-hydroxy-3-oxosuccinate + H(+) + NADH
REACT:R-DRE-8875659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Danio rerio)
GO:0005527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrolide binding
RHEA:46464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-76426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-atom dealkylation of caffeine (Danio rerio)
REACT:R-SSC-919404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT5 is released (Sus scrofa)
REACT:R-HSA-8964513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
REACT:R-MMU-9032073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-phosphorylated FRS2 binds GRB2 (Mus musculus)
REACT:R-CFA-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)
RHEA:21421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin I2 => 15-dehydro-prostaglandin I2 + H(+) + NADPH
REACT:R-HSA-193695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK interacts with TRAF6 (Homo sapiens)
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ganglioside GM3 synthase activity
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GM3 synthetase activity
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CMP-acetylneuraminate-lactosylceramide-sialyltransferase
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-sialic acid:lactosylceramide-sialyltransferase activity
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SAT 1
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GM3 synthase activity
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ganglioside GM3 synthetase activity
GO:0047291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactosylceramide alpha-2,3-sialyltransferase activity
REACT:R-PFA-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
RHEA:38630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-HSA-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)
RHEA:72524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine + S-adenosyl-L-methionine => 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine
RHEA:46300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
RHEA:52126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:51686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + CDP => (2E,6E)-farnesyl phosphate + CTP
REACT:R-RNO-5675431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates RAF1 (Rattus norvegicus)
RHEA:57088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)
REACT:R-MMU-388503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxytocin receptor bind oxytocin (Mus musculus)
REACT:R-HSA-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Homo sapiens)
REACT:R-GGA-2247513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1:ligand is endocytosed (Gallus gallus)
REACT:R-BTA-192042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Bos taurus)
REACT:R-RNO-2473596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP15 (Rattus norvegicus)
REACT:R-CFA-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Canis familiaris)
RHEA:47123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + glycine <=> H2O + N-docosanoylglycine
REACT:R-RNO-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Rattus norvegicus)
GO:0016709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
REACT:R-MMU-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Mus musculus)
REACT:R-CFA-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Canis familiaris)
RHEA:26416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary amine + an aldehyde + H2O2 => a secondary aliphatic amine + H2O + O2
RHEA:20354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chloride + H(+) + trichloroethene => AH2 + tetrachloroethene
GO:0003998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylphosphate phosphohydrolase activity
GO:0003998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylphosphatase activity
GO:0003998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylphosphatase activity
GO:0003998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetic phosphatase activity
GO:0003998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-diphosphoglycerate phosphatase activity
GO:0003998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GP 1-3
GO:0003998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ho 1-3
RHEA:56667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
RHEA:24546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+) => H2O + L-lysyl-[protein] + O2
RHEA:66248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + IC-asc-C9-AMP = AMP + H(+) + IC-asc-C9-CoA
RHEA:64787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-ethyl-L-cysteine <=> 2-aminoprop-2-enoate + ethanethiol
RHEA:21603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + benzoyl-CoA <=> CoA + N-benzoylanthranilate
RHEA:45539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine
REACT:R-DRE-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Danio rerio)
REACT:R-MMU-8853800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARTN binds RET:GFRA1,GFRA3 (Mus musculus)
RHEA:51491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaetidylserine + H(+) <=> archaetidylethanolamine + CO2
REACT:R-RNO-444606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R2/T1R3 dimer is a sweet taste receptor (Rattus norvegicus)
REACT:R-HSA-177479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Axonal transport of NGF:Trk complexes (Homo sapiens)
RHEA:67099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + asnovolin A + 2 O2 <=> CO2 + fumigatonoid A + succinate
RHEA:51005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + 2 Fe(III)-[cytochrome cL] => an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)
RHEA:11390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11-oxosteroid + H(+) + NADPH => an 11beta-hydroxysteroid + NADP(+)
REACT:R-RNO-450551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 binds translation and heat shock proteins (Rattus norvegicus)
RHEA:68863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxo-25-hydroxycholesterol + H(+) + NADPH <=> 7beta-25-dihydroxycholesterol + NADP(+)
RHEA:22913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine + pyruvate => 3-methyl-2-oxobutanoate + L-alanine
RHEA:40764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Re + H2O => (20S)-ginsenoside Rg1 + L-rhamnopyranose
RHEA:35389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine => precorrin-7 + S-adenosyl-L-methionine
REACT:R-XTR-193655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myelin components can interact with p75NTR:NgR:LINGO1 (Xenopus tropicalis)
RHEA:19235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + L-cysteinyl-[protein] => H2O + S-hexadecanoyl-L-cysteinyl-[protein]
REACT:R-XTR-1234177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)
REACT:R-DDI-3900194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates DDX5 with SUMO2 (Dictyostelium discoideum)
REACT:R-MMU-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Mus musculus)
REACT:R-CFA-5357828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8 (Canis familiaris)
REACT:R-HSA-453346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGB b dimer:AMP complex <=> PGYB dimer, b form + 2 AMP (Homo sapiens)
RHEA:49905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2
REACT:R-CFA-3341397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
REACT:R-CFA-1606583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Canis familiaris)
REACT:R-BTA-445797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLK (MLCK) Active Calmodulin Binding (Bos taurus)
REACT:R-BTA-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
RHEA:17784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-methionine <=> formate + L-methionine
RHEA:11890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + 2 H(+) + NADPH => an aldehyde + H2O + NADP(+)
REACT:R-DME-6804425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F2 (Drosophila melanogaster)
REACT:R-DRE-2028598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS1 (Danio rerio)
REACT:R-BTA-5362386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Hh (Bos taurus)
REACT:R-SSC-917891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Sus scrofa)
REACT:R-CFA-5433067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Canis familiaris)
REACT:R-SSC-216727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Sus scrofa)
RHEA:53996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-SCE-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Saccharomyces cerevisiae)
RHEA:53159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
GO:0010293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"abscisic-aldehyde oxidase"
GO:0010293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisic aldehyde + H2O + O2 = 2-cis-(+)-abscisate + H(+) + H2O2
GO:0010293	skos:prefLabel	"abscisic-aldehyde oxidase"
GO:0010293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	abscisic-aldehyde oxidase activity
GO:0010293	skos:altLabel	"AOdelta"
GO:0010293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisic aldehyde oxidase activity
GO:0010293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	abscisic-aldehyde:oxygen oxidoreductase activity
GO:0010293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AAO3
GO:0010293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AOdelta
REACT:R-MMU-2172433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIX degradation (Mus musculus)
REACT:R-MMU-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Mus musculus)
RHEA:31055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate + H2O = estrone + H(+) + sulfate
GO:0001530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS binding
GO:0001530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide binding
GO:0001530	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endotoxin binding
REACT:R-DME-390252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Drosophila melanogaster)
RHEA:68724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-9027628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises EPA to 5-HEPE (Xenopus tropicalis)
EC:3.4.21.82	skos:altLabel	"glutamic acid-specific protease"
EC:3.4.21.82	skos:prefLabel	"glutamyl endopeptidase II"
EC:3.4.21.82	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamyl endopeptidase II"
EC:3.4.21.82	skos:altLabel	"GluSGP"
REACT:R-HSA-9685950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of protein 3a (Homo sapiens)
GO:0047120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity
GO:0047120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity
GO:0047120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terephthalate 1,2-cis-dihydrodiol dehydrogenase activity
GO:0047120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity
GO:0047120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity
GO:0047120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)
GO:0102782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanol hydroxylase activity
RHEA:42722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2552) in 23S rRNA
REACT:R-RNO-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)
RHEA:24406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + acetyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA
RHEA:24701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol
REACT:R-BTA-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Bos taurus)
REACT:R-BTA-751019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:G12/13 complex dissociates (Bos taurus)
RHEA:21879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) <=> (S)-usnate + 2 H(+) + NADH
RHEA:50134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + H(+) + hexadecanoate => ethyl hexadecanoate + H2O
REACT:R-BTA-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Bos taurus)
REACT:R-CFA-166175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Canis familiaris)
RHEA:44735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)
GO:0047667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylic acid:deoxythymidine 5'-phosphotransferase activity
GO:0047667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylate-nucleoside phosphotransferase activity
GO:0047667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine phosphotransferase activity
GO:0047667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP-thymidine kinase activity
GO:0047667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP:thymidine 5'-phosphotransferase activity
GO:0047667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP:dThd kinase activity
GO:0047667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP:deoxythymidine kinase activity
GO:0047667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP:deoxythymidine 5'-phosphotransferase activity
REACT:R-RNO-9718360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide agonists (Rattus norvegicus)
REACT:R-BTA-5621354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Bos taurus)
REACT:R-HSA-376369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp2 associated secretory vesicle to plasma membrane transport (Homo sapiens)
GO:0034787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity
REACT:R-BTA-5672027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Bos taurus)
REACT:R-DRE-9724753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds anti-fibrinolytics (Danio rerio)
REACT:R-CEL-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Caenorhabditis elegans)
REACT:R-HSA-2161951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Homo sapiens)
REACT:R-XTR-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Xenopus tropicalis)
REACT:R-SSC-5627071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Sus scrofa)
RHEA:35768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosterigmatocystin + S-adenosyl-L-methionine => 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine
RHEA:39147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA
REACT:R-MMU-216072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Mus musculus)
REACT:R-DRE-2730903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of TRAF6 (Danio rerio)
REACT:R-CEL-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Caenorhabditis elegans)
RHEA:35857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA
RHEA:27730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) = beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate
REACT:R-DRE-442749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the nucleus (Danio rerio)
RHEA:53733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate => 2-hydroxy-7,8-dihydropteroate + diphosphate
REACT:R-GGA-9645414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Gallus gallus)
RHEA:66119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-glutamine <=> (2S)-2-aminobutanoate + 2-oxoglutaramate
REACT:R-GGA-375339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Gallus gallus)
REACT:R-HSA-8876262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB (Homo sapiens)
REACT:R-CFA-210282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GPVI and FceRI gamma (Canis familiaris)
RHEA:66268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + nonanoyl-AMP = AMP + H(+) + nonanoyl-CoA
REACT:R-HSA-5621606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD209 binds ManLAM (Homo sapiens)
RHEA:49139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl-[protein] + NADPH + O2 <=> H2O + L-methionyl-S-oxide-[protein] + NADP(+)
RHEA:46146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]
EC:1.21.3.7	skos:altLabel	"Delta(1)-tetrahydrocannabinolic acid synthase"
EC:1.21.3.7	skos:altLabel	"THCA synthase"
EC:1.21.3.7	skos:prefLabel	"tetrahydrocannabinolic acid synthase"
EC:1.21.3.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrahydrocannabinolic acid synthase"
REACT:R-RNO-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Rattus norvegicus)
REACT:R-BTA-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Bos taurus)
GO:0140826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc:proton antiporter activity
GO:0140826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out)
REACT:R-CFA-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)
REACT:R-MMU-444572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zinc is an agonist of GPR39 (Mus musculus)
RHEA:64063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH
RHEA:65552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + lactose
REACT:R-GGA-8855131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9 binds Clathrin-coated vesicles (Gallus gallus)
REACT:R-GGA-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Gallus gallus)
REACT:R-MMU-517536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Mus musculus)
REACT:R-HSA-9036104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)
REACT:R-XTR-159783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)
REACT:R-XTR-8955844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBKS phosphorylates ribose to R5P (Xenopus tropicalis)
REACT:R-HSA-8864698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers  (Homo sapiens)
RHEA:28242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pratensein + reduced [NADPH--hemoprotein reductase] = 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline => a 1-acyl-sn-glycero-3-phosphocholine
EC:3.2.1.97	skos:altLabel	"mucinaminylserine mucinaminidase"
EC:3.2.1.97	skos:altLabel	"glycopeptide alpha-N-acetylgalactosaminidase"
EC:3.2.1.97	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endo-alpha-N-acetylgalactosaminidase"
EC:3.2.1.97	skos:altLabel	"D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase"
EC:3.2.1.97	skos:prefLabel	"endo-alpha-N-acetylgalactosaminidase"
EC:3.2.1.97	skos:altLabel	"D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine mucinaminohydrolase"
EC:3.2.1.97	skos:altLabel	"endo-alpha-N-acetyl-D-galactosaminidase"
EC:3.2.1.97	skos:altLabel	"endo-alpha-acetylgalactosaminidase"
EC:3.2.1.97	skos:altLabel	"endo-alpha-GalNAc-ase"
EC:1.14.18.5	skos:altLabel	"sphingolipid C4-hydroxylase"
EC:1.14.18.5	skos:prefLabel	"sphingolipid C4-monooxygenase"
EC:1.14.18.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingolipid C4-monooxygenase"
EC:1.14.18.5	skos:altLabel	"sphinganine C4-monooxygenase"
RHEA:62658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate
REACT:R-RNO-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Rattus norvegicus)
REACT:R-RNO-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Rattus norvegicus)
RHEA:72008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate(in) + urate(out) => succinate(out) + urate(in)
REACT:R-BTA-8854303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D11 binds RAB6 (Bos taurus)
REACT:R-MMU-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Mus musculus)
RHEA:72150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + S-adenosyl-L-methionine + UTP <=> 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine
REACT:R-MMU-5649799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Mus musculus)
REACT:R-RNO-162729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Rattus norvegicus)
RHEA:35110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitrotyramine + H2O + O2 <=> 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)
GO:0047824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-iditol 2-dehydrogenase activity
REACT:R-BTA-380942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LKB1 forms a trimeric complex with STRAD and MO25 (Bos taurus)
RHEA:25566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-4-O-acetylneuraminate
REACT:R-RNO-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Rattus norvegicus)
REACT:R-CFA-6800200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-HGF to form HGF dimer (Canis familiaris)
RHEA:54323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Bos taurus)
REACT:R-CFA-5649764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Canis familiaris)
REACT:R-BTA-8870352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Bos taurus)
REACT:R-CFA-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Canis familiaris)
RHEA:33529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate => acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol
REACT:R-HSA-175108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Target DNA binding (Homo sapiens)
RHEA:45292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
REACT:R-GGA-5218642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Gallus gallus)
RHEA:59507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + glycyl-L-cysteinyl-[protein] + H(+) <=> [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]
REACT:R-HSA-9022314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates MECP2 (Homo sapiens)
RHEA:55229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-9670673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIX is secreted (Canis familiaris)
RHEA:70898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-cysteinyl-[protein] + O2 <=> H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]
REACT:R-DME-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Drosophila melanogaster)
RHEA:23539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate <=> alpha-D-glucose 6-phosphate
REACT:R-RNO-873918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of JAK1 (Rattus norvegicus)
REACT:R-DDI-6788523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to Complex I subunits (Dictyostelium discoideum)
REACT:R-SPO-114684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Syntaxin-4 (Schizosaccharomyces pombe)
REACT:R-CFA-5205649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 links damaged mitochondria to LC3 (Canis familiaris)
REACT:R-GGA-6784791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Gallus gallus)
GO:0050569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolaldehyde:NAD+ oxidoreductase activity
GO:0050569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolaldehyde dehydrogenase activity
GO:0050569	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycol aldehyde dehydrogenase activity
REACT:R-SPO-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
REACT:R-HSA-983194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-1 is a heterotetramer (Homo sapiens)
RHEA:31469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(beta-D-glucosyl) crocetin + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose
REACT:R-CFA-8987150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Canis familiaris)
RHEA:62879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate <=> A + semiviriditoxin
RHEA:70072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + sitosterol => (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Sus scrofa)
GO:0050243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
GO:0050243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:NADP+ oxidoreductase activity
GO:0050243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:NADP(+) oxidoreductase activity
GO:0050243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate dehydrogenase (NADP+) activity
REACT:R-DDI-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Dictyostelium discoideum)
REACT:R-RNO-174967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT2 acetylation (Rattus norvegicus)
REACT:R-HSA-9027275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)
RHEA:37929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-DME-937311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP12A:ATP4B exchanges K+ for H+ (Drosophila melanogaster)
RHEA:49963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 <=> 5,10-dihydrophenazine + CO2 + H2O2
REACT:R-CEL-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Caenorhabditis elegans)
RHEA:65618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholest-4-en-3-one + AH2 => A + cholest-4-en-3-one + H2O
REACT:R-HSA-5244424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
REACT:R-DRE-9033527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Danio rerio)
REACT:R-CFA-3296326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR1 binds LACT (Canis familiaris)
GO:0015437	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-coupled intramembrane lipopolysaccharide transporter activity
GO:0015437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide-transporting ATPase activity
GO:0015437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide floppase activity (cytosolic to exoplasmic leaftlet)
GO:0015437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS-transporting ATPase activity
GO:0015437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide floppase activity
GO:0015437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent intramembrane lipopolysaccharide transporter activity
RHEA:56585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-epoxypropane + H2O => propane-1,2-diol
RHEA:53291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-scyllo-inosose + H2O <=> 5-dehydro-L-gluconate + H(+)
REACT:R-MMU-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Mus musculus)
REACT:R-SSC-76434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of carbon tetrachloride to form a free radical (Sus scrofa)
REACT:R-XTR-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Xenopus tropicalis)
RHEA:49244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin E1 = 18-oxo-resolvin E1 + H(+) + NADH
GO:0044685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity
REACT:R-DME-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Drosophila melanogaster)
REACT:R-XTR-1793186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Xenopus tropicalis)
REACT:R-HSA-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Homo sapiens)
REACT:R-GGA-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Gallus gallus)
REACT:R-BTA-2730833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TEC kinases by p-SYK (Bos taurus)
RHEA:63159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-docosanoyl-taurine <=> docosanoate + taurine
RHEA:68722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lanosterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-190427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1b (Sus scrofa)
REACT:R-XTR-909729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JAK kinases (Xenopus tropicalis)
REACT:R-BTA-9635739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)
RHEA:44210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyltridecanoyl-CoA + AMP + diphosphate => 12-methyltridecanoate + ATP + CoA
GO:0050419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)
GO:0050419	skos:prefLabel	"hydroxymandelonitrile lyase"
GO:0050419	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxynitrile lyase activity
GO:0050419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrogen cyanide
GO:0050419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sorghum hydroxynitrile lyase activity
GO:0050419	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity
GO:0050419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymandelonitrile lyase activity
GO:0050419	skos:altLabel	"(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase"
GO:0050419	skos:altLabel	"hydroxynitrile lyase"
GO:0050419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxymandelonitrile lyase"
RHEA:58951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
RHEA:63396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + Fe(II)-heme i + H2O = AH2 + Fe(II)-hydroxyheme i
RHEA:45952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparaginyl-[protein] + UDP-alpha-D-glucose = H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP
REACT:R-HSA-388900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurotensin receptors can bind neurotensins (Homo sapiens)
REACT:R-SCE-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Saccharomyces cerevisiae)
RHEA:32160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + epoxyqueuosine(34) in tRNA => A + H2O + queuosine(34) in tRNA
RHEA:44169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + 2 H(+) + NADH => dodecanal + H2O + NAD(+)
REACT:R-SSC-9624120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK2 (Sus scrofa)
RHEA:62962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol(out) => 7-dehydrocholesterol(in)
REACT:R-BTA-6783556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIFR:JAKs bind gp130:JAKs:CNTFR (Bos taurus)
RHEA:14096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-tryptophan <=> indole-3-pyruvate + L-glutamate
REACT:R-SCE-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)
RHEA:49068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]
RHEA:36367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-alpha-hydroxyglutarate-gamma-lactone + H2O = 2-hydroxyglutarate + H(+)
RHEA:48187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:42182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:59037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:47177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O
GO:0004163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphomevalonate decarboxylase activity
GO:0004163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonate diphosphate decarboxylase activity
GO:0004163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)
GO:0004163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)
GO:0004163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphomevalonate decarboxylase activity
GO:0004163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonate pyrophosphate decarboxylase activity
GO:0004163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonate-5-pyrophosphate decarboxylase activity
GO:0004163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphomevalonic acid decarboxylase activity
GO:0004163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonate 5-diphosphate decarboxylase activity
GO:0004163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-pyrophosphomevalonate decarboxylase activity
REACT:R-DDI-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Dictyostelium discoideum)
REACT:R-GGA-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Gallus gallus)
REACT:R-DRE-4641134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds AXIN (Danio rerio)
RHEA:21580	skos:altLabel	"(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase"
RHEA:21580	skos:prefLabel	"acetolactate decarboxylase"
RHEA:21580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2
RHEA:21580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetolactate decarboxylase"
RHEA:51848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-methylmenaquinone-6 + succinate = 8-methylmenaquinol-6 + fumarate
GO:0043798	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycerate kinase
GO:0043798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerate 2-kinase activity
GO:0043798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycerate 2-kinase activity
RHEA:24800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O <=> (S)-2-amino-6-oxoheptanedioate
REACT:R-SSC-3465459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Sus scrofa)
REACT:R-CEL-170844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 is cleaved by FURIN (Caenorhabditis elegans)
REACT:R-HSA-5672304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Homo sapiens)
REACT:R-PFA-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Plasmodium falciparum)
GO:0004410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homocitrate synthase activity
GO:0004410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
GO:0004410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity
GO:0004410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homocitrate synthetase activity
GO:0004410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)
GO:0004410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity
REACT:R-HSA-5661039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane (Homo sapiens)
RHEA:69424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutanoyl-CoA = acetone + formyl-CoA
REACT:R-MMU-8849881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM2 associate with AMPA and NMDA receptors (Mus musculus)
RHEA:64778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol => 3-sulfanylpentan-1-ol-L-cysteine
RHEA:49917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)
GO:0102760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxocathasterone hydroxylase activity
REACT:R-GGA-193691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kB migrates to the nucleus and turns on transcription (Gallus gallus)
RHEA:10139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glyoxylate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2
RHEA:68488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxytetradecanoate + H(+) = CO2 + H2O + tridecanal
RHEA:45166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O
RHEA:10859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP
RHEA:14457	skos:altLabel	"3-(n-propyl)-malate synthase"
RHEA:14457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)
RHEA:14457	skos:altLabel	"beta-n-propylmalate synthase"
RHEA:14457	skos:prefLabel	"3-propylmalate synthase"
RHEA:14457	skos:altLabel	"3-propylmalate glyoxylate-lyase (CoA-pentanoylating)"
RHEA:14457	skos:altLabel	"n-propylmalate synthase"
RHEA:14457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-propylmalate synthase"
REACT:R-SSC-6804229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMY, TTC5 and EP300 bind (Sus scrofa)
REACT:R-BTA-3000434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Bos taurus)
RHEA:43519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-5-formylfuran + H2O <=> 2-carboxy-5-(dihydroxymethyl)furan
RHEA:40930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)
REACT:R-GGA-2424486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)
RHEA:13134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + di-trans,poly-cis-dolichol => a dolichyl phosphate + CDP + H(+)
REACT:R-MMU-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Mus musculus)
RHEA:64015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine <=> A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine
REACT:R-XTR-5684250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Xenopus tropicalis)
REACT:R-CFA-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Canis familiaris)
RHEA:12257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arogenate + NAD(+) => CO2 + L-tyrosine + NADH
REACT:R-CFA-1602398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Canis familiaris)
RHEA:60916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in mRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:28252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CO2 + CoA => acetyl-CoA + H(+) + malonyl-CoA
RHEA:20319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline-2-carboxylate + H(+) + NADPH => L-proline + NADP(+)
RHEA:23104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arabinose-5-phosphate isomerase"
RHEA:23104	skos:altLabel	"phosphoarabinoisomerase"
RHEA:23104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose 5-phosphate = D-ribulose 5-phosphate
RHEA:23104	skos:altLabel	"arabinose phosphate isomerase"
RHEA:23104	skos:prefLabel	"arabinose-5-phosphate isomerase"
REACT:R-GGA-8875451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates CBL (Gallus gallus)
REACT:R-PFA-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Plasmodium falciparum)
REACT:R-RNO-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Rattus norvegicus)
REACT:R-DME-2872498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Drosophila melanogaster)
RHEA:36068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-6B + S-adenosyl-L-methionine => Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine
REACT:R-GGA-1250348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by ERBB4 homodimers (Gallus gallus)
REACT:R-DRE-5689973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10,USP24,USP42 deubiquitinate TP53 (Danio rerio)
REACT:R-DDI-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Dictyostelium discoideum)
RHEA:53999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-CFA-6800794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 associates with CRADD (Canis familiaris)
REACT:R-HSA-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Homo sapiens)
REACT:R-XTR-194518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoA is activated by nucleotide exchange and inhibits axonal growth (Xenopus tropicalis)
RHEA:38408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)
REACT:R-MMU-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Mus musculus)
RHEA:54299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-tyrosyl-[protein] <=> diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]
RHEA:16061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn-glycerol 3-phosphate
RHEA:16061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerophosphocholine phosphodiesterase"
RHEA:16061	skos:prefLabel	"glycerophosphocholine phosphodiesterase"
REACT:R-RNO-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Rattus norvegicus)
REACT:R-SSC-9014434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GAPs stimulate RHOG GTPase activity (Sus scrofa)
RHEA:57625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-6788523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to Complex I subunits (Rattus norvegicus)
RHEA:70684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-normetanephrine + S-adenosyl-L-methionine => (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine
RHEA:54969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl phosphate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate
REACT:R-RNO-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)
REACT:R-SPO-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Schizosaccharomyces pombe)
RHEA:30011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-galactose(out) + H2O = ADP + beta-D-galactose(in) + H(+) + phosphate
REACT:R-DRE-5653936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Ragulator complex (Danio rerio)
REACT:R-SSC-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Sus scrofa)
REACT:R-GGA-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Gallus gallus)
GO:0018453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytetrahydrofuran dehydrogenase activity
REACT:R-HSA-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Homo sapiens)
RHEA:41298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(hexanoyl)sphing-4-enine <=> hexanoate + sphing-4-enine
GO:0052934	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ethanol:cytochrome c oxidoreductase activity
GO:0052934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alcohol:(acceptor) oxidoreductase activity
GO:0052934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol:cytochrome c oxidoreductase activity
GO:0052934	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alcohol dehydrogenase (acceptor) activity
GO:0052934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinoprotein alcohol dehydrogenase activity
GO:0052934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol dehydrogenase (cytochrome c) activity
GO:0052934	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	2-chloroethanol:cytochrome c oxidoreductase activity
GO:0052934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alcohol:acceptor oxidoreductase activity
GO:0052934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQQ-dependent alcohol dehydrogenase activity
RHEA:68785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => diphosphate + gamma-curcumene
REACT:R-CEL-210426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamate synaptic vesicle docking and priming (Caenorhabditis elegans)
RHEA:17155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-6-deoxy-D-glucose + H2O => CDP-D-glucose
RHEA:33242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine + NAD(+) <=> aminoacetone + CO2 + NADH
RHEA:53040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:64065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-pseudoephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
REACT:R-DME-381135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Drosophila melanogaster)
RHEA:44337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + ATP + L-arginine => ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate
RHEA:34408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate
RHEA:32935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)
REACT:R-CEL-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Caenorhabditis elegans)
RHEA:32644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + lupanine => 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-MMU-5690785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds Ub-HCFC1 (Mus musculus)
REACT:R-XTR-9009558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds SDC1 (Xenopus tropicalis)
REACT:R-GGA-390846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2D3,4 bind to DA (Gallus gallus)
RHEA:32905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => calciol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:39731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-5357845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is deubiquitinated (Rattus norvegicus)
RHEA:37213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 2'-monophosphate + H(+) => 2',3'-cyclophospho-GMP + H2O
RHEA:30012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-galactose(out) + H2O => ADP + beta-D-galactose(in) + H(+) + phosphate
GO:0031882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 5 somatostatin receptor binding
GO:0031882	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 5 somatostatin receptor ligand
REACT:R-HSA-9729835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 nsp9 binds to 7SL RNA (Homo sapiens)
GO:1990269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II C-terminal domain phosphoserine binding
GO:1990269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNAP II C-terminal domain phosphoserine binding
GO:1990269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain phosphoserine binding
GO:0015533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	shikimate:proton symporter activity
GO:0015533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	shikimate:hydrogen symporter activity
GO:0033726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldehyde ferredoxin oxidoreductase"
GO:0033726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde ferredoxin oxidoreductase activity
GO:0033726	skos:altLabel	"tungsten-containing aldehyde ferredoxin oxidoreductase"
GO:0033726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AOR
GO:0033726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tungsten-containing aldehyde ferredoxin oxidoreductase activity
GO:0033726	skos:prefLabel	"aldehyde ferredoxin oxidoreductase"
GO:0033726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0033726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde:ferredoxin oxidoreductase activity
GO:0033726	skos:altLabel	"AOR"
REACT:R-MMU-8987097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Mus musculus)
REACT:R-MMU-2179415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Mus musculus)
GO:0047718	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indan-1-ol:NAD(P)+ 1-oxidoreductase activity
GO:0047718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indanol dehydrogenase activity
REACT:R-DRE-9024881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Danio rerio)
RHEA:24782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + pyropheophorbide a => C-13(2)-carboxypyropheophorbide a + H(+)
RHEA:28652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + O2 => 9-riburonosylhypoxanthine + H(+) + H2O
REACT:R-DRE-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Danio rerio)
REACT:R-GGA-2395320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 binds integrins (Gallus gallus)
RHEA:36955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA = (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-XTR-9613264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Xenopus tropicalis)
REACT:R-HSA-1168813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS binding to JAK2 (Homo sapiens)
REACT:R-HSA-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Homo sapiens)
REACT:R-SSC-1855205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Sus scrofa)
RHEA:72609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + AMP + H(+) => (E)-sinapoyl-AMP + CoA
RHEA:12201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + 2-oxoglutarate + O2 => CO2 + mugineate + succinate
RHEA:61578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH => (4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+)
REACT:R-DRE-8849435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 dephosphorylates PTK6 (Danio rerio)
REACT:R-HSA-180736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of the Rev-importin beta-B23:Ran-GTP complex (Homo sapiens)
RHEA:41394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O
RHEA:22206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + homogentisate + NADP(+) => 3-hydroxyphenylacetate + H(+) + NADPH + O2
REACT:R-HSA-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Homo sapiens)
REACT:R-DRE-418845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of caspase-3 (Danio rerio)
REACT:R-DRE-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Danio rerio)
REACT:R-DME-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Drosophila melanogaster)
GO:0045484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine:2-oxoglutarate 6-aminotransferase activity
GO:0045484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine-alpha-ketoglutarate 6-aminotransferase activity
GO:0045484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine aminotransferase activity
GO:0045484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine:2-ketoglutarate 6-aminotransferase activity
GO:0045484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine transaminase activity
GO:0045484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine-alpha-ketoglutarate aminotransferase activity
GO:0045484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine 6-aminotransferase activity
GO:0045484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine 6-transaminase activity
GO:0045484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine epsilon-transaminase activity
GO:0045484	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine epsilon-aminotransferase activity
REACT:R-HSA-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Homo sapiens)
REACT:R-CFA-561253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A12 exchanges extracellular urate for cytosolic LACT (Canis familiaris)
REACT:R-GGA-997309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of STAT1 by SHP2 (Gallus gallus)
RHEA:25596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + isochorismate <=> 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2
RHEA:50083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurodeoxycholate(in) <=> ADP + H(+) + phosphate + taurodeoxycholate(out)
REACT:R-DRE-5082384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70:DNAJB1 binds HSF1 (Danio rerio)
REACT:R-XTR-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Xenopus tropicalis)
RHEA:70016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + teasterone => 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:3.4.21.66	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thermitase"
EC:3.4.21.66	skos:altLabel	"thermophilic Streptomyces serine protease"
EC:3.4.21.66	skos:prefLabel	"thermitase"
RHEA:30551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + beta-D-glucose = 6-O-acetyl-beta-D-glucose + CoA
RHEA:38822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DME-6814187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVL:PPL heterodimer binds the inner surface of the plasma membrane (Drosophila melanogaster)
REACT:R-HSA-73718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBF-1 Binds rDNA Promoter (Homo sapiens)
REACT:R-SSC-9688459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds HSP90:CDC37 (Sus scrofa)
RHEA:67968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + presqualene diphosphate = H(+) + phosphate + presqualene monophosphate
RHEA:28833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate(out) + H(+)(out) => D-gluconate(in) + H(+)(in)
RHEA:20312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 <=> 2 H2O + O2
REACT:R-HSA-76354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)
REACT:R-MMU-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Mus musculus)
REACT:R-SSC-445113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Urotensin-2 receptor binds urotensin-2 and 2B (Sus scrofa)
RHEA:25920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-7-ol = 7-hydroxyquinolin-2(1H)-one + AH2
REACT:R-XTR-211948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 can N-demethylate loperamide (Xenopus tropicalis)
REACT:R-XTR-9700200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRZ dephosphorylates ligand-bound ALK dimers (Xenopus tropicalis)
RHEA:34508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate => N,N-diacetyllegionaminate + phosphate
REACT:R-SCE-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Saccharomyces cerevisiae)
REACT:R-CEL-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Caenorhabditis elegans)
REACT:R-RNO-879674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD97 binds CD55 (Rattus norvegicus)
REACT:R-CEL-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)
REACT:R-CEL-167419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex releases GDP (Caenorhabditis elegans)
REACT:R-CFA-5686642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD52 promotes single strand annealing at resected DNA DSBs (Canis familiaris)
RHEA:35893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-HSA-421007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of Ca impermeable AMPA receptors (Homo sapiens)
REACT:R-SPO-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Schizosaccharomyces pombe)
RHEA:40855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + undecanoyl-CoA = FADH2 + trans-2-undecenoyl-CoA
RHEA:55247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O
RHEA:54698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate => 4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase]
RHEA:16912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + glycine + H2O <=> 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)
REACT:R-RNO-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Rattus norvegicus)
RHEA:62325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2
RHEA:50989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin F2alpha(out) => prostaglandin F2alpha(in)
RHEA:63586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxyecdysone + phosphate => 2-deoxyecdysone 22-phosphate + H2O
RHEA:44737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dihydroxyacetone phosphate => 3-hydroxy-2,4-dioxopentyl phosphate + CoA
RHEA:11689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu)
REACT:R-GGA-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Gallus gallus)
REACT:R-MMU-140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Mus musculus)
GO:0008911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-lactaldehyde:NAD+ oxidoreductase activity
GO:0008911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactaldehyde dehydrogenase activity
GO:0008911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lactaldehyde:NAD oxidoreductase activity
GO:0008911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity
RHEA:57169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2
RHEA:35242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracycline(in) <=> tetracycline(out)
RHEA:50782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H(+) + NADPH => NADP(+) + octanal
REACT:R-DRE-417843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y13 binds ADP (Danio rerio)
REACT:R-RNO-201472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Rattus norvegicus)
RHEA:43042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoylhexadecasphinganine => hexadecanoyl-CoA + hexadecasphinganine
REACT:R-GGA-6804485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates L3MBTL2 with SUMO2 (Gallus gallus)
REACT:R-RNO-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Rattus norvegicus)
RHEA:37009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA
REACT:R-HSA-1169403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 ligase with ISG15:E2 complex (Homo sapiens)
GO:0015324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-acetyl-CoA secondary active transmembrane transporter activity
GO:0015324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide-acetyl-CoA transporter activity
REACT:R-DME-9627107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP7 (Drosophila melanogaster)
RHEA:68387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] <=> (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate
REACT:R-BTA-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Bos taurus)
REACT:R-MMU-9620515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2B,EP300 acetylate FOXO3 under oxidative stress (Mus musculus)
REACT:R-MMU-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Mus musculus)
RHEA:53907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[tau protein] <=> ADP + H(+) + O-phospho-L-threonyl-[tau protein]
REACT:R-SSC-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Sus scrofa)
RHEA:59351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltobiono-1,5-lactone + H2O <=> D-maltobionate + H(+)
REACT:R-XTR-6810392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMEM55B translocates to the nucleus (Xenopus tropicalis)
REACT:R-CFA-8987266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Canis familiaris)
REACT:R-XTR-1605591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Xenopus tropicalis)
REACT:R-DRE-212005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2F1 dehydrogenates 3-methylindole (Danio rerio)
RHEA:25476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = alpha-himachalene + diphosphate
REACT:R-DRE-2045911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)
REACT:R-DRE-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Danio rerio)
RHEA:11576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine = AMP + H(+) + thiamine diphosphate
RHEA:11576	skos:altLabel	"Thiamine kinase"
RHEA:11576	skos:altLabel	"thiamine pyrophosphokinase"
RHEA:11576	skos:prefLabel	"thiamine diphosphokinase"
RHEA:11576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiamine diphosphokinase"
REACT:R-HSA-9005340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SOCS3 (Homo sapiens)
RHEA:11035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> 3-chloro-cis,cis-muconate + H(+)
REACT:R-DRE-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Danio rerio)
REACT:R-BTA-419428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR2-5 bind S1P (Bos taurus)
REACT:R-HSA-8944247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VI (Homo sapiens)
RHEA:65544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc
REACT:R-CFA-9632033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GalNAc to chondroitin (Canis familiaris)
REACT:R-MMU-9011984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A is recruited to MYC and BCL2 genes (Mus musculus)
GO:0047101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoisovalerate dehydrogenase (acylating) activity
GO:0047101	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoisovalerate dehydrogenase activity
GO:0047101	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)
GO:0047101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + CoA + NAD(+) = 2-methylpropanoyl-CoA + CO2 + NADH
REACT:R-CFA-374758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Somatostatin receptors bind somatostatin and cortistatin (Canis familiaris)
REACT:R-RNO-5634802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Rattus norvegicus)
REACT:R-HSA-388809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTLA-4 binds B7-1/B7-2 (Homo sapiens)
GO:0070337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-flap-structured DNA binding
REACT:R-SPO-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Schizosaccharomyces pombe)
RHEA:10955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + hydroxymalonate <=> (E)-sinapoyltartronate + CoA
REACT:R-SCE-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Saccharomyces cerevisiae)
RHEA:37460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + ATP => 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
RHEA:33943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 L-arginine + 3 NADH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide
REACT:R-HSA-392129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
REACT:R-XTR-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Xenopus tropicalis)
RHEA:49569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-en-1-ol => (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione
REACT:R-MMU-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Mus musculus)
REACT:R-HSA-9613210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1, EGR2 bind the RRAD promoter (Homo sapiens)
REACT:R-MMU-6786171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 deubiquitination by USP1:WDR48 (Mus musculus)
RHEA:16636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(34) in tRNA + queuine <=> guanine + queuosine(34) in tRNA
REACT:R-CFA-9646348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Canis familiaris)
REACT:R-CFA-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Canis familiaris)
REACT:R-MMU-1250220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of ERBB4 (Mus musculus)
RHEA:22165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside Forssman (d18:1(4E)) + H(+) + UDP
REACT:R-DRE-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Danio rerio)
REACT:R-BTA-216756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)
REACT:R-SSC-9640168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Sus scrofa)
RHEA:65860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + Delta(1)-dihydrotestosterone + H2O = 17beta-hydroxyandrostan-1,3-dione + AH2
REACT:R-GGA-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Gallus gallus)
REACT:R-DME-198824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Drosophila melanogaster)
REACT:R-SPO-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Schizosaccharomyces pombe)
RHEA:50437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H1 => prostaglandin E1
RHEA:50011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylpretetramide + 2 H(+) + NADPH + O2 <=> 4-hydroxy-6-methylpretetramide + H2O + NADP(+)
RHEA:47390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic alcohol + H(+) + tetradecanoate => a tetradecanoate ester + H2O
REACT:R-DRE-352191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A8-mediated uptake of neutral amino acids (Danio rerio)
REACT:R-HSA-2423785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR:atREs binds apoE and HSPG (Homo sapiens)
RHEA:52982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]
REACT:R-SPO-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Schizosaccharomyces pombe)
RHEA:71379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) = D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)
RHEA:47333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0004816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparaginyl transfer ribonucleic acid synthetase activity
GO:0004816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine translase activity
GO:0004816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparaginyl-tRNA synthetase activity
GO:0004816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-asparagine:tRNAAsn ligase (AMP-forming)
GO:0004816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparaginyl transfer RNA synthetase activity
GO:0004816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparaginyl-transfer ribonucleate synthetase activity
GO:0004816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagyl-transfer RNA synthetase activity
GO:0004816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagine-tRNA ligase activity
REACT:R-PFA-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Plasmodium falciparum)
REACT:R-DME-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Drosophila melanogaster)
RHEA:56129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dimethylallyl diphosphate + H2O + nonaflavuxanthin => AH2 + diphosphate + flavuxanthin
REACT:R-HSA-6782336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAT1 deaminates adenosine-37 in tRNA(Ala) (Homo sapiens)
REACT:R-XTR-9733403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds PCSK9 inhibitors (Xenopus tropicalis)
RHEA:33097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	futalosine => chorismate + inosine + phosphoenolpyruvate
REACT:R-DRE-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Danio rerio)
GO:0140489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular template activity
REACT:R-HSA-8955844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBKS phosphorylates ribose to R5P (Homo sapiens)
RHEA:14764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + L-serine <=> 3-oxosphinganine + CO2 + CoA
REACT:R-SSC-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Sus scrofa)
RHEA:26158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosone + H(+) + NADPH => D-mannose + NADP(+)
RHEA:70618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]
REACT:R-DRE-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)
REACT:R-MMU-6813740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDE1 hydrolyzes GroPIns (Mus musculus)
RHEA:60846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate => a 5'-end diphospho-guanosine in mRNA + GTP + H(+)
RHEA:47346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin] => 7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:62650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2
RHEA:16864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine <=> (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate
RHEA:53467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate
RHEA:35178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	novobiocin(in) <=> novobiocin(out)
REACT:R-HSA-109998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Homo sapiens)
REACT:R-RNO-5626228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The distal appendage proteins recruit TTBK2 (Rattus norvegicus)
RHEA:68317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 2,4,5-triphosphate + phosphate
REACT:R-MMU-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Mus musculus)
RHEA:10044	skos:prefLabel	"cyclohexanol dehydrogenase"
RHEA:10044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexanol dehydrogenase"
RHEA:10044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanol + NAD(+) = cyclohexanone + H(+) + NADH
REACT:R-HSA-8982709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) (Homo sapiens)
RHEA:21257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoshikimate + phosphoenolpyruvate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate
REACT:R-HSA-9032327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-EPA, 15d-PGJ3 translocate from cytosol to extracellular region (Homo sapiens)
REACT:R-DRE-2028651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Danio rerio)
REACT:R-BTA-5684267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
REACT:R-DRE-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Danio rerio)
REACT:R-BTA-8863858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC22B, CALR, STX4, TAP and TAPBP bind (Bos taurus)
RHEA:70789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-citrulline(out) + L-ornithine(in) => H(+)(in) + L-citrulline(in) + L-ornithine(out)
REACT:R-XTR-450133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP binds MYD88 homodimer (Xenopus tropicalis)
RHEA:44905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + H2O => alpha-D-glucose + phosphate
REACT:R-XTR-8940959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurolysin degrades neurotensin (Xenopus tropicalis)
RHEA:54071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + sesterfisherol
RHEA:20588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin
RHEA:40900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
REACT:R-RNO-2530501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTA:FNTB transfers FARN to GNGT1 (Rattus norvegicus)
REACT:R-MMU-3640858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase ADP-ribosylates AXIN (Mus musculus)
RHEA:28202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:28202	skos:altLabel	"light-independent protochlorophyllide reductase"
RHEA:28202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin:protochlorophyllide reductase (ATP-dependent)"
RHEA:28202	skos:prefLabel	"ferredoxin:protochlorophyllide reductase (ATP-dependent)"
REACT:R-CFA-433711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-homodimerization of nectins (Canis familiaris)
REACT:R-HSA-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)
RHEA:65881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-5alpha-androstan-3,17-dione + A => 5alpha-androstan-1,3,17-trione + AH2
RHEA:20015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-carbamoyl-L-aspartate + phosphate => carbamoyl phosphate + L-aspartate
REACT:R-HSA-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Homo sapiens)
REACT:R-RNO-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Rattus norvegicus)
GO:0004448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IDH activity
GO:0004448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitric dehydrogenase activity
GO:0004448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalosuccinic decarboxylase activity
GO:0004448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalosuccinate carboxylase activity
GO:0004448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate dehydrogenase activity
GO:0004448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IDP activity
GO:0004448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate dehydrogenase [NAD(P)+] activity
GO:0004448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalosuccinate decarboxylase activity
GO:0004448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitric acid dehydrogenase activity
REACT:R-MMU-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Mus musculus)
REACT:R-XTR-109671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Xenopus tropicalis)
REACT:R-MMU-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Mus musculus)
RHEA:23844	skos:prefLabel	"sedoheptulokinase"
RHEA:23844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sedoheptulokinase"
RHEA:23844	skos:altLabel	"heptulokinase"
RHEA:23844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + sedoheptulose = ADP + D-sedoheptulose 7-phosphate + H(+)
REACT:R-HSA-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Homo sapiens)
RHEA:48061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose
RHEA:39200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O
RHEA:13127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-glutathione + glutathione => CoA + glutathione disulfide
REACT:R-XTR-3134946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 ubiquitination by TRIM21 (Xenopus tropicalis)
REACT:R-MMU-196950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTRAP hydrolyzes FMN to RIB (Mus musculus)
RHEA:50616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH
REACT:R-HSA-9768788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-224 binds NPAS4 mRNA (Homo sapiens)
REACT:R-DRE-5691439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRISC complex deubiquitinates NLRP3 (Danio rerio)
REACT:R-HSA-6810894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking (Homo sapiens)
REACT:R-SSC-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Sus scrofa)
REACT:R-HSA-381377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of KLF5 (Homo sapiens)
RHEA:60693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-enal + H2O + NADP(+) => (E)-non-2-enoate + 2 H(+) + NADPH
GO:0003960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a quinone + H(+) + NADPH = 2 a 1,4-benzosemiquinone + NADP(+)
GO:0003960	skos:altLabel	"quinone oxidoreductase"
GO:0003960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:quinone oxidoreductase activity
GO:0003960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH:quinone reductase activity
GO:0003960	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	quinone oxidoreductase activity
GO:0003960	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	zeta-crystallin activity
GO:0003960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADPH:quinone reductase"
GO:0003960	skos:altLabel	"zeta-crystallin"
GO:0003960	skos:prefLabel	"NADPH:quinone reductase"
REACT:R-HSA-420724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds Ca2+ (Homo sapiens)
REACT:R-HSA-75240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8   (Homo sapiens)
REACT:R-BTA-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Bos taurus)
REACT:R-CEL-8937191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Caenorhabditis elegans)
RHEA:32178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)
REACT:R-XTR-199206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Xenopus tropicalis)
REACT:R-DDI-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Dictyostelium discoideum)
REACT:R-HSA-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)
RHEA:30700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + beta-alanine => 3-oxopropanoate + L-glutamate
REACT:R-CFA-5672958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from KSR1:MARK3 (Canis familiaris)
REACT:R-SSC-8941628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
REACT:R-BTA-9707186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 binds ALOX5 inhibitors (Bos taurus)
REACT:R-PFA-5423038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Plasmodium falciparum)
REACT:R-RNO-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Rattus norvegicus)
REACT:R-DDI-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Dictyostelium discoideum)
RHEA:72325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(in) + thiosulfate(in) => 3 Na(+)(out) + thiosulfate(out)
REACT:R-XTR-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Xenopus tropicalis)
RHEA:15995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+) => anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2
RHEA:43505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethylfurfural + O2 => 2,5-diformylfuran + H2O2
REACT:R-CFA-110141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Canis familiaris)
REACT:R-GGA-8950269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Gallus gallus)
RHEA:29762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanoate(in) <=> octanoate(out)
RHEA:53752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP
REACT:R-BTA-1564142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV degradation by MMP2,3,4,9,10,12 (Bos taurus)
RHEA:52814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O
RHEA:42203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + NADP(+) <=> 11-dehydrocorticosterone + H(+) + NADPH
RHEA:70577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + UMP => 3',5'-cyclic UMP + H2O
REACT:R-RNO-373714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-Heterodimerization of nephrin and KIRREL (Rattus norvegicus)
REACT:R-GGA-9647977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT methylates S-Farn RAS proteins (Gallus gallus)
GO:0031708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endothelin B receptor binding
GO:0031708	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endothelin B receptor ligand
RHEA:67051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chermesin D + O2 <=> A + asnovolin I + H2O
REACT:R-CEL-9012349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Caenorhabditis elegans)
REACT:R-HSA-964773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXGR1 binds 2OG (Homo sapiens)
REACT:R-SSC-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Sus scrofa)
RHEA:31586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-dATP + H2O <=> 2-oxo-dAMP + diphosphate + H(+)
REACT:R-XTR-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Xenopus tropicalis)
REACT:R-BTA-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Bos taurus)
REACT:R-CFA-3222116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L3MBTL1 binds TP53 monomethylated on K382 (Canis familiaris)
REACT:R-RNO-5610758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Rattus norvegicus)
REACT:R-MMU-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Mus musculus)
REACT:R-DRE-76434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of carbon tetrachloride to form a free radical (Danio rerio)
REACT:R-GGA-9733403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds PCSK9 inhibitors (Gallus gallus)
REACT:R-MMU-9627089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP9 is phosphorylated at T125 (Mus musculus)
REACT:R-BTA-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Bos taurus)
REACT:R-RNO-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Rattus norvegicus)
RHEA:24684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH => 5,10-methylenetetrahydromethanopterin + NADP(+)
REACT:R-GGA-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Gallus gallus)
REACT:R-CFA-8964605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Canis familiaris)
GO:0045301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylthio-cis-ribozeatin hydroxylase activity
GO:0045301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-(ms2io6A)-hydroxylase activity
GO:0045301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity
GO:0045301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity
REACT:R-HSA-8876454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND3 exchanges GTP for GDP on RAB12 (Homo sapiens)
REACT:R-SSC-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Sus scrofa)
REACT:R-CFA-9020275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DHA to 17(S)-Hp-DHA (Canis familiaris)
REACT:R-DDI-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Dictyostelium discoideum)
REACT:R-XTR-8848606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates PXN (Xenopus tropicalis)
REACT:R-HSA-446130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 2 binds Interleukin 1 (Homo sapiens)
REACT:R-MMU-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Mus musculus)
REACT:R-CFA-8980228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Canis familiaris)
RHEA:69979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:19194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-13,14-dihydroretinol => AH2 + all-trans-retinol
RHEA:58764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)
REACT:R-MMU-9009309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STUB1 (Mus musculus)
REACT:R-CFA-389941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP-1 and SHP-2 bind pBTLA (Canis familiaris)
REACT:R-SPO-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Schizosaccharomyces pombe)
REACT:R-CFA-9012556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Canis familiaris)
RHEA:52530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuccinamate + L-glutamate => 2-oxoglutarate + L-asparagine
REACT:R-HSA-2161666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGA2 is isomerised to PGC2 (Homo sapiens)
RHEA:71458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	goralatide + H2O <=> L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate
RHEA:37302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-threonine <=> L-alanine + L-threonine
REACT:R-RNO-204863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang2 (Rattus norvegicus)
REACT:R-XTR-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-GGA-8865107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MICAL1 produces NADP+, H2O2 (Gallus gallus)
REACT:R-DME-8964284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in active Gq-BTK complex is activated (Drosophila melanogaster)
REACT:R-RNO-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)
RHEA:38149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonyl sulfide + H(+) + hydrogen sulfide => carbon disulfide + H2O
GO:0018562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity
REACT:R-DME-209215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CI activates transcription (Drosophila melanogaster)
RHEA:21124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine
GO:0046553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-malate dehydrogenase activity
GO:0046553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-malate dehydrogenase (decarboxylating) activity
GO:0046553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-malate:NAD+ oxidoreductase (decarboxylating)
GO:0046553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)
GO:0046553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-malic enzyme
RHEA:19133	skos:prefLabel	"thyroid-hormone transaminase"
RHEA:19133	skos:altLabel	"3,5-dinitrotyrosine aminotransferase"
RHEA:19133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thyroid-hormone transaminase"
RHEA:19133	skos:altLabel	"thyroid-hormone aminotransferase"
RHEA:19133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3,3',5-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate
REACT:R-RNO-170964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 binds to active TrkA receptor (Rattus norvegicus)
RHEA:15645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] = 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate
RHEA:15645	skos:prefLabel	"nitrogenase (flavodoxin)"
RHEA:15645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrogenase (flavodoxin)"
RHEA:51120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 = (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O
REACT:R-DME-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Drosophila melanogaster)
GO:0140721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclease inhibitor activity
REACT:R-CEL-5251955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)
RHEA:17715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine => (R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Danio rerio)
RHEA:38835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
GO:0035515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidative RNA demethylase activity
GO:0035515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA demethylases demethylate N6-methyladenosine RNA (Homo sapiens)
GO:0035515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate-dependent RNA demethylase
REACT:R-GGA-2426471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Gallus gallus)
RHEA:42199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0019155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(imidazol-5-yl)lactate dehydrogenase activity
GO:0019155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazol-5-yl lactate dehydrogenase activity
GO:0019155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity
RHEA:51965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:15464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-GGA-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Gallus gallus)
REACT:R-GGA-9762343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDL:ALB dissociates (Gallus gallus)
REACT:R-RNO-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Rattus norvegicus)
RHEA:52397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-D-threonate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH
REACT:R-HSA-937337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Homo sapiens)
RHEA:22826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-alpha-D-ribose 1-phosphate + uracil => 2'-deoxyuridine + phosphate
REACT:R-DME-6781922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds UFD1L:SKP2 (Drosophila melanogaster)
REACT:R-DRE-6784791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Danio rerio)
RHEA:19096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + siroheme <=> 12,18-didecarboxysiroheme + 2 CO2
RHEA:19426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + imidazole-4-acetate + NADH + O2 => 5-hydroxyimidazole-4-acetate + H2O + NAD(+)
RHEA:19806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine D-ribonucleoside + phosphate => a purine nucleobase + alpha-D-ribose 1-phosphate
REACT:R-HSA-1497794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)
REACT:R-DME-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)
REACT:R-BTA-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
GO:0034189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL binding
GO:0034189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-low-density lipoprotein particle binding
GO:0034189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-low-density lipoprotein binding
RHEA:38297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + AH2 => (R)-2-hydroxyglutarate + A
RHEA:53574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Sus scrofa)
RHEA:36447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-proline(out) + H2O = ADP + glycyl-L-proline(in) + H(+) + phosphate
RHEA:55088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eburicol + S-adenosyl-L-methionine = (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine
RHEA:32558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> (R)-alpha-terpineol + diphosphate
EC:1.1.1.320	skos:prefLabel	"benzil reductase [(S)-benzoin forming]"
EC:1.1.1.320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzil reductase [(S)-benzoin forming]"
REACT:R-GGA-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Gallus gallus)
REACT:R-MMU-391913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR2 binds FPR2 ligands (Mus musculus)
REACT:R-RNO-173626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1r (Rattus norvegicus)
REACT:R-MMU-8944254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVI (Mus musculus)
REACT:R-DRE-444838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 1 binds relaxin 2 and 3 (Danio rerio)
REACT:R-CEL-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)
REACT:R-DRE-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Danio rerio)
GO:0042085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity
GO:0004318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl-[acyl-carrier protein] reductase (NADH) activity
GO:0004318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH
GO:0004318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enoyl-[acyl-carrier-protein] reductase (NADH)"
GO:0004318	skos:altLabel	"NADH-enoyl acyl carrier protein reductase"
GO:0004318	skos:altLabel	"NADH-specific enoyl-ACP reductase"
GO:0004318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0004318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl-acyl-carrier-protein reductase (NADH)
GO:0004318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl-ACP reductase (NADH) activity
GO:0004318	skos:prefLabel	"enoyl-[acyl-carrier-protein] reductase (NADH)"
GO:0004318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-specific enoyl-ACP reductase activity
GO:0004318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-enoyl acyl carrier protein reductase activity
GO:0004318	skos:altLabel	"enoyl-ACP reductase"
GO:0004318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein:NAD+ oxidoreductase
RHEA:20698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + O2 => 2 H(+) + 2 superoxide
REACT:R-SSC-5625848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)
GO:0047503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-borneol:NAD+ oxidoreductase activity
GO:0047503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-borneol dehydrogenase activity
RHEA:10427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-benzoylglycine <=> benzoate + glycine
REACT:R-BTA-5696534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 deubiquitinates TAK1:TAB1 (Bos taurus)
RHEA:49782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-docosanoylglycine => docosanoyl-CoA + glycine
REACT:R-CEL-936390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD mediated deubiquitination of DDX58 (RIG-I) (Caenorhabditis elegans)
GO:0044588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laminaribiose binding
REACT:R-SPO-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Schizosaccharomyces pombe)
REACT:R-RNO-70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Rattus norvegicus)
RHEA:52359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + pregnenolone <=> adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate
REACT:R-BTA-1482543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Bos taurus)
REACT:R-CFA-203774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Csk with PAG (Canis familiaris)
REACT:R-CEL-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Caenorhabditis elegans)
REACT:R-RNO-5687094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 phosphorylate MAPKAPK5 (Rattus norvegicus)
REACT:R-RNO-8856223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Rattus norvegicus)
REACT:R-DRE-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Danio rerio)
RHEA:25732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-tetrahomomethionine => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O
REACT:R-BTA-5654167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds PLCG1 (Bos taurus)
REACT:R-HSA-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Homo sapiens)
RHEA:12845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanophycinase"
RHEA:12845	skos:altLabel	"cyanophycin granule polypeptidase"
RHEA:12845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate
RHEA:12845	skos:prefLabel	"cyanophycinase"
RHEA:12845	skos:altLabel	"CGPase"
RHEA:12845	skos:altLabel	"cyanophycin degrading enzyme"
RHEA:12845	skos:altLabel	"beta-Asp-Arg hydrolyzing enzyme"
REACT:R-HSA-8867288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 (Homo sapiens)
REACT:R-SSC-2090043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(7) (Sus scrofa)
REACT:R-DRE-3000122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD320 binds extracellular TCN2:RCbl (Danio rerio)
RHEA:19292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sucrose 6(F)-phosphate <=> phosphate + sucrose
REACT:R-BTA-191062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of Klotho-bound FGFR1c (Bos taurus)
RHEA:28332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + IDP + phosphate => H2O + ITP
RHEA:31034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl cis-(+)-abscisate + UDP
REACT:R-MMU-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Mus musculus)
REACT:R-DDI-622310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD1 oligomerizes (Dictyostelium discoideum)
REACT:R-DME-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Drosophila melanogaster)
REACT:R-RNO-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Rattus norvegicus)
RHEA:65735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + heptyl sulfate + O2 <=> CO2 + H(+) + heptanal + succinate + sulfate
REACT:R-DME-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Drosophila melanogaster)
REACT:R-CFA-8869456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP4 deubiquitinate TRAF2,TRAF6 (Canis familiaris)
REACT:R-RNO-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Rattus norvegicus)
REACT:R-CFA-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Canis familiaris)
RHEA:58065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin => 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Schizosaccharomyces pombe)
REACT:R-MMU-5693373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)
REACT:R-MMU-2466085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from R* to release atRAL (Mus musculus)
REACT:R-SSC-170843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 phosphorylates TGFBR1 (Sus scrofa)
REACT:R-CFA-5340195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4 binds DCA, CDCA, LCHA (Canis familiaris)
REACT:R-RNO-158313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XII -> factor XIIa (Rattus norvegicus)
REACT:R-HSA-350186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN binds GC:25(OH)D (Homo sapiens)
RHEA:21695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glycerol + H2O <=> CMP + 2 H(+) + sn-glycerol 3-phosphate
REACT:R-SSC-9755303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades HIFalpha (Sus scrofa)
GO:0033745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity
GO:0033745	skos:prefLabel	"L-methionine (R)-S-oxide reductase"
GO:0033745	skos:altLabel	"free met-R-(o) reductase"
GO:0033745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	free met-R-(o) reductase activity
GO:0033745	skos:altLabel	"FRMsr"
GO:0033745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine-(R)-S-oxide reductase activity
GO:0033745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FRMsr
GO:0033745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-methionine (R)-S-oxide reductase"
GO:0033745	skos:altLabel	"free-methionine (R)-S-oxide reductase"
GO:0033745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	free-methionine (R)-S-oxide reductase activity
GO:0033745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxide
REACT:R-BTA-2509816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses IDP to IMP (Bos taurus)
REACT:R-SSC-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Sus scrofa)
RHEA:56464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-XTR-389348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by pVav1 (Xenopus tropicalis)
GO:0015081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium transporter activity
GO:0015081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium ion transmembrane transporter activity
GO:0015081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) = Na(+)(out)
REACT:R-DRE-5218854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y420-FYN is phosphorylated on S21 (Danio rerio)
RHEA:62754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylbutanoate + H(+) + pravastatin diol lactone => H2O + pravastatin lactone
REACT:R-HSA-109538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Homo sapiens)
RHEA:45122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ipsdienone + NADH => (4R)-ipsdienol + NAD(+)
REACT:R-RNO-8953398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIR oxygenates quercetin (Rattus norvegicus)
RHEA:47125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hexacosanoate => H2O + N-hexacosanoylglycine
RHEA:29442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(in) + H(+)(out) <=> Fe(2+)(out) + H(+)(in)
REACT:R-HSA-9665415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)
RHEA:61250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => H2O + L-tyrosine + O2
RHEA:69856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in mRNA + NADP(+) => a uridine in mRNA + H(+) + NADPH
RHEA:68381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + L-asparagine => 2-oxosuccinamate + L-serine
RHEA:31030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl trans-(+)-abscisate + UDP
GO:0016826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on sulfur-nitrogen bonds"
GO:0016826	skos:prefLabel	"Acting on sulfur-nitrogen bonds"
GO:0016826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid sulphur-nitrogen bonds
GO:0016826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid sulfur-nitrogen bonds
REACT:R-DRE-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Danio rerio)
REACT:R-MMU-109387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Mus musculus)
REACT:R-CFA-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Canis familiaris)
RHEA:60628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + gluconapin + O2 = A + H2O + progoitrin
REACT:R-DME-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Drosophila melanogaster)
RHEA:45235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)
RHEA:64939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + H2O <=> dGDP + H(+) + phosphate
REACT:R-HSA-1671691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR-bound STAT5 is phosphorylated (Homo sapiens)
RHEA:26488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteate + phosphate => H(+) + O-phospho-L-serine + sulfite
RHEA:47154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 2 H(+) + NADH => 2,5-dioxopentanoate + H2O + NAD(+)
GO:0016211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammonia ligase activity
RHEA:20543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2
GO:0047317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epsilon-acetyl-beta-lysine aminotransferase activity
GO:0047317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity
GO:0047317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-acetyl-beta-lysine aminotransferase activity
GO:0047317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(6)-acetyl-beta-lysine aminotransferase activity
GO:0047317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-acetyl-beta-lysine transaminase activity
REACT:R-BTA-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Bos taurus)
REACT:R-CEL-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Caenorhabditis elegans)
REACT:R-SSC-3215295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates MDM2 (Sus scrofa)
REACT:R-SSC-156808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Sus scrofa)
REACT:R-HSA-9683679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquination of protein E (Homo sapiens)
RHEA:28497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + dimethyl sulfide + H2O <=> a menaquinol + dimethyl sulfoxide
REACT:R-RNO-4085347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO1 (Rattus norvegicus)
REACT:R-CFA-8964271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in PIP3:BTK:G beta-gamma complex is activated (Canis familiaris)
EC:3.4.22.53	skos:prefLabel	"calpain-2"
EC:3.4.22.53	skos:altLabel	"m-calpain"
EC:3.4.22.53	skos:altLabel	"milli-calpain"
EC:3.4.22.53	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"calpain-2"
EC:3.4.22.53	skos:altLabel	"calcium-activated neutral protease II"
REACT:R-HSA-2530453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vitronectin (VTN) binds to C5b:C6:C7 (Homo sapiens)
RHEA:45492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]
RHEA:38819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:60238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2
REACT:R-RNO-8850786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK12 (Rattus norvegicus)
GO:0016503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pheromone receptor activity
GO:0018457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	perillyl-alcohol dehydrogenase activity
GO:0018457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	perillyl-alcohol:NAD+ oxidoreductase activity
GO:0018457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	perillyl alcohol dehydrogenase activity
RHEA:23346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine nucleobase + D-ribose => a purine D-ribonucleoside + H2O
REACT:R-DRE-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Danio rerio)
RHEA:45082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dapdiamide E + H(+) + phosphate => 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine
RHEA:49292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--D-cellobiose phosphotransferase"
RHEA:49292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]
RHEA:49292	skos:altLabel	"D-cellobiose PTS permease"
RHEA:49292	skos:prefLabel	"protein-N(pi)-phosphohistidine--D-cellobiose phosphotransferase"
REACT:R-RNO-2467809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)
REACT:R-RNO-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
REACT:R-SCE-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)
REACT:R-DRE-388811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-1 homodimer (Danio rerio)
RHEA:20001	skos:prefLabel	"glycolaldehyde dehydrogenase"
RHEA:20001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycolaldehyde dehydrogenase"
RHEA:20001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolaldehyde + H2O + NAD(+) = glycolate + 2 H(+) + NADH
REACT:R-SSC-904830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
RHEA:61882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-DRE-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Danio rerio)
GO:0102304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sesquithujene synthase activity
RHEA:11505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-demethylsterigmatocystin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sterigmatocystin
RHEA:16559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomuconate 6-semialdehyde + CO2 => 2-amino-3-carboxymuconate 6-semialdehyde + H(+)
RHEA:50634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 2-(omega-methylsulfanyl)alkylmalate
REACT:R-XTR-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Xenopus tropicalis)
RHEA:65589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-4568914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of BLM with SUMO2,3 (Drosophila melanogaster)
GO:0031741	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type B gastrin/cholecystokinin receptor ligand
GO:0031741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type B gastrin/cholecystokinin receptor binding
REACT:R-HSA-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Homo sapiens)
REACT:R-DME-2731078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 2, (4) bind TGFB1 (Drosophila melanogaster)
REACT:R-CFA-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Canis familiaris)
REACT:R-XTR-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Xenopus tropicalis)
RHEA:24328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + phosphate
RHEA:24328	skos:altLabel	"formyl dihydrofolate synthase"
RHEA:24328	skos:prefLabel	"formate--dihydrofolate ligase"
RHEA:24328	skos:altLabel	"dihydrofolate formyltransferase"
RHEA:24328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate--dihydrofolate ligase"
GO:0031369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation initiation factor binding
REACT:R-MTU-936665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPS is added to the carrier sulfide (Mycobacterium tuberculosis)
RHEA:10918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate
RHEA:12032	skos:prefLabel	"acyloxyacyl hydrolase"
RHEA:12032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
RHEA:12032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyloxyacyl hydrolase"
REACT:R-XTR-2855054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-2 binds to molecular patterns on the target cell surface  (Xenopus tropicalis)
REACT:R-MMU-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Mus musculus)
RHEA:62464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-GGA-375302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules (Gallus gallus)
RHEA:35240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracycline(in) => tetracycline(out)
EC:3.2.1.75	skos:altLabel	"endo-1,6-beta-glucanase"
EC:3.2.1.75	skos:altLabel	"endo-1,6-beta-D-glucanase"
EC:3.2.1.75	skos:prefLabel	"glucan endo-1,6-beta-glucosidase"
EC:3.2.1.75	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan endo-1,6-beta-glucosidase"
EC:3.2.1.75	skos:altLabel	"beta-1,6-glucanase"
REACT:R-GGA-8871266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD3 (Gallus gallus)
REACT:R-RNO-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Rattus norvegicus)
RHEA:61594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine => H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine
REACT:R-RNO-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Rattus norvegicus)
RHEA:22185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) => acenaphthene-1,2-dione + 2 H(+) + 2 NADPH
GO:0031861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prolactin-releasing peptide receptor binding
GO:0031861	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	prolactin-releasing peptide receptor ligand
GO:0009702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinokinase activity
GO:0009702	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arabinokinase (phosphorylating)
GO:0009702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:L-arabinose 1-phosphotransferase activity
RHEA:44051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
RHEA:11891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + NADP(+) <=> a carboxylate + 2 H(+) + NADPH
REACT:R-CFA-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Canis familiaris)
REACT:R-RNO-5694077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Rattus norvegicus)
REACT:R-HSA-744887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
REACT:R-GGA-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Gallus gallus)
REACT:R-GGA-5638007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 activates the GTPase activity of ARL3 (Gallus gallus)
RHEA:26058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H(+) + valienol 1-phosphate <=> diphosphate + GDP-valienol
REACT:R-MMU-1602446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Mus musculus)
REACT:R-CFA-1971483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Canis familiaris)
REACT:R-SSC-2327695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Sus scrofa)
REACT:R-DRE-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Danio rerio)
REACT:R-RNO-5626681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of transition zone proteins (Rattus norvegicus)
RHEA:54241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
GO:0047082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)
GO:0047082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0047082	skos:prefLabel	"3,9-dihydroxypterocarpan 6a-monooxygenase"
GO:0047082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,9-dihydroxypterocarpan 6alpha-monooxygenase
GO:0047082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,9-dihydroxypterocarpan 6a-monooxygenase activity
GO:0047082	skos:altLabel	"CYP93A1"
GO:0047082	skos:altLabel	"3,9-dihydroxypterocarpan 6a-hydroxylase"
GO:0047082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,9-dihydroxypterocarpan 6a-hydroxylase activity
GO:0047082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,9-dihydroxypterocarpan 6a-monooxygenase"
REACT:R-BTA-964773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXGR1 binds 2OG (Bos taurus)
REACT:R-DME-378513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Drosophila melanogaster)
RHEA:65958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + estrone 3-sulfate(in) + H(+) + phosphate => ATP + estrone 3-sulfate(out) + H2O
RHEA:49986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-12-hydroxyjasmonate + H2O + NADP(+) => H(+) + jasmonate + NADPH + O2
RHEA:10841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-homoserine => L-threonine + phosphate
RHEA:63629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hexadecanoate + holo-[ACP] => AMP + diphosphate + hexadecanoyl-[ACP]
RHEA:43642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanoyl-[ACP] + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-[ACP]
REACT:R-RNO-114259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase‑9 to caspase‑9 (Rattus norvegicus)
REACT:R-SSC-9614271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ADGRG6 (Sus scrofa)
RHEA:64140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-asparagine + H2O = a fatty acid + L-asparagine
RHEA:54955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + nonanoate <=> AMP + diphosphate + nonanoyl-CoA
GO:0102164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity
RHEA:51860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + umbelliferone = 8-geranylumbelliferone + diphosphate
REACT:R-CFA-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Canis familiaris)
REACT:R-DRE-9011949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Danio rerio)
REACT:R-HSA-6793975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GATA3 (Homo sapiens)
RHEA:69635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
REACT:R-HSA-9692146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DHH in testis differentiation (Homo sapiens)
REACT:R-CEL-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)
REACT:R-CFA-5218952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Canis familiaris)
RHEA:26116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => diphosphate + epi-cedrol
RHEA:24176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:24176	skos:prefLabel	"tRNA uracil 4-sulfurtransferase"
RHEA:24176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA uracil 4-sulfurtransferase"
RHEA:24176	skos:altLabel	"tRNA sulfurtransferase"
RHEA:34913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methionine(out) => D-methionine(in)
REACT:R-MMU-6791227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Mus musculus)
REACT:R-GGA-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Gallus gallus)
REACT:R-DME-5578966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A:AGO2:miRNA is transported into the nucleus (Drosophila melanogaster)
REACT:R-BTA-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Bos taurus)
GO:0033809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3MaT
GO:0033809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanin 6''-O-malonyltransferase"
GO:0033809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Dv3MaT
GO:0033809	skos:prefLabel	"anthocyanin 6''-O-malonyltransferase"
GO:0033809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity
GO:0033809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA = an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA
GO:0033809	skos:altLabel	"3MaT"
GO:0033809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin 6''-O-malonyltransferase activity
GO:0033809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity
GO:0047201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucogallin O-galloyltransferase activity
GO:0047201	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity
GO:0102450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferide 7-O-methyltransferase activity
REACT:R-GGA-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Gallus gallus)
RHEA:46542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:69519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-galactosamine + O2 <=> H2O2 + N-acetyl-D-galactosamino-1,5-lactone
REACT:R-HSA-9609738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2C (GRIN2C) (Homo sapiens)
REACT:R-DME-70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Drosophila melanogaster)
REACT:R-HSA-1504193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)
REACT:R-GGA-451900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RB binds JAK1 (Gallus gallus)
RHEA:10026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => L-lysyl-[histone] + S-adenosyl-L-methionine
REACT:R-HSA-194518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoA is activated by nucleotide exchange and inhibits axonal growth (Homo sapiens)
REACT:R-BTA-444691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prokineticin receptors bind prokineticin (Bos taurus)
RHEA:18833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-formylbenzenesulfonate + H2O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH
RHEA:18833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-formylbenzenesulfonate dehydrogenase"
RHEA:18833	skos:prefLabel	"4-formylbenzenesulfonate dehydrogenase"
RHEA:37568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-GGA-5660666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBP and p300 binds NF-kB complex (Gallus gallus)
RHEA:20722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + L-2-aminoadipate + penicillin G => H2O + isopenicillin N + phenylacetyl-CoA
REACT:R-PFA-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-DME-416639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Drosophila melanogaster)
REACT:R-DRE-5682010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10:ATG12 binds ATG5 (Danio rerio)
REACT:R-CEL-350901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is organified (Caenorhabditis elegans)
RHEA:66367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O <=> 6-methyl-3,7-dioxodecanedioyl-CoA
RHEA:71469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7) => H2O + substance P
REACT:R-HSA-6786245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNS1 transforms ATP, L-His, b-Ala to CARN (Homo sapiens)
REACT:R-SPO-379464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DOPAC to form HVA (Schizosaccharomyces pombe)
REACT:R-SSC-9035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysS248-MPST:TXN2 dissociates (Sus scrofa)
REACT:R-DME-1971487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHSY3 transfer GalNAc to chondroitin (Drosophila melanogaster)
REACT:R-RNO-4724284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Rattus norvegicus)
REACT:R-BTA-2201338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds TICAM1:activated TLR4 complex (Bos taurus)
REACT:R-GGA-1112604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STATs are released (Gallus gallus)
REACT:R-BTA-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Bos taurus)
REACT:R-CFA-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Canis familiaris)
REACT:R-XTR-433099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS2 co-transports sulphate and two sodium ions (Xenopus tropicalis)
RHEA:66517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:10985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + oxaloacetate => (S)-malate + pyruvate
RHEA:66317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O => alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)
REACT:R-XTR-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Xenopus tropicalis)
REACT:R-HSA-8943007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)
REACT:R-GGA-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Gallus gallus)
REACT:R-DRE-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Danio rerio)
REACT:R-HSA-6781922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds UFD1L:SKP2 (Homo sapiens)
REACT:R-SSC-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Sus scrofa)
GO:0034857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(methylthio)benzothiazole monooxygenase activity
RHEA:39920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O => 1-O-(alk-1-enyl)-sn-glycerol + phosphate
RHEA:31948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-8944223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type V (Rattus norvegicus)
REACT:R-BTA-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Bos taurus)
RHEA:66121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-methionine => (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate
REACT:R-HSA-1678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses CS/HS precursor (Homo sapiens)
REACT:R-DME-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Drosophila melanogaster)
REACT:R-MMU-1482629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)
REACT:R-SSC-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Sus scrofa)
RHEA:50465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH => 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)
REACT:R-BTA-3785684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by CTSG (Bos taurus)
RHEA:61859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 <=> betaenone C + 3 H2O + 3 NADP(+)
REACT:R-RNO-9007882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 is cleaved (Rattus norvegicus)
REACT:R-XTR-451900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RB binds JAK1 (Xenopus tropicalis)
RHEA:16727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phosphatidylglycerol + phosphate => a phosphatidylglycerol phosphate + H2O
RHEA:49161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Drosophila melanogaster)
RHEA:58962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + H(+) + H2O2 => benzaldehyde + H2O + O2
RHEA:32818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hg(2+)(in) <=> Hg(2+)(out)
RHEA:15046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) => (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH
RHEA:36101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl benzoate + S-adenosyl-L-homocysteine => benzoate + S-adenosyl-L-methionine
GO:0099119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-8 3-O-methyltransferase activity
REACT:R-SSC-265429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Sus scrofa)
RHEA:12269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + putrescine => 1-pyrroline + H2O + L-glutamate
GO:0042907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthine transmembrane transporter activity
REACT:R-XTR-5358340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoproteolytic cleavage of Hh precursors (Xenopus tropicalis)
RHEA:70833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-leucine(in) + Na(+)(in) => L-arginine(in) + L-leucine(out) + Na(+)(out)
RHEA:29340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + 2 H(+)(in) => (S)-malate(out) + 2 H(+)(out)
RHEA:37607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
GO:0016151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nickel cation binding
GO:0016151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ni binding
GO:0016151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nickel binding
REACT:R-PFA-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Plasmodium falciparum)
REACT:R-SSC-177935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)
REACT:R-CEL-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Caenorhabditis elegans)
RHEA:18944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) <=> a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH
RHEA:34423	skos:prefLabel	"(+)-lariciresinol reductase"
RHEA:34423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-secoisolariciresinol + NADP(+) = (+)-lariciresinol + H(+) + NADPH
RHEA:34423	skos:altLabel	"(+)-pinoresinol-(+)-lariciresinol reductase"
RHEA:34423	skos:altLabel	"(+)-pinoresinol/(+)-lariciresinol"
RHEA:34423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-lariciresinol reductase"
RHEA:34423	skos:altLabel	"pinoresinol-lariciresinol reductases"
RHEA:34423	skos:altLabel	"pinoresinol/lariciresinol reductase"
REACT:R-BTA-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Bos taurus)
RHEA:65650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine
REACT:R-XTR-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Xenopus tropicalis)
REACT:R-HSA-5692794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO1 positively regulates RAG gene expression  (Homo sapiens)
REACT:R-RNO-8875591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK7 activates RAC1 (Rattus norvegicus)
RHEA:12563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone + UDP-alpha-D-glucose <=> H(+) + hydroquinone O-beta-D-glucopyranoside + UDP
RHEA:61874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2
GO:0060230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoprotein lipase activator activity
REACT:R-HSA-421416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proglucagon translocates from the ER Lumen to secretory granules (Homo sapiens)
RHEA:34413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabidiolate + H2O2 => cannabigerolate + O2
REACT:R-CFA-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Canis familiaris)
REACT:R-CFA-159729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)
RHEA:15385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-cyanoalanine hydratase"
RHEA:15385	skos:prefLabel	"3-cyanoalanine hydratase"
RHEA:15385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine = 3-cyano-L-alanine + H2O
REACT:R-BTA-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Bos taurus)
RHEA:30212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + nitrous oxide => 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide
REACT:R-DRE-433101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Danio rerio)
REACT:R-DDI-5693575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PKcs autophosphorylates (Dictyostelium discoideum)
REACT:R-CEL-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Caenorhabditis elegans)
GO:0005292	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	high affinity lysine transporter activity
GO:0005292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity lysine transmembrane transporter activity
GO:0005292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity lysine transmembrane transporter activity
REACT:R-SSC-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Sus scrofa)
REACT:R-SSC-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Sus scrofa)
REACT:R-XTR-183130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Xenopus tropicalis)
REACT:R-HSA-5663293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RORA, EP300 bind SREBF1 gene (Homo sapiens)
REACT:R-DME-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Drosophila melanogaster)
REACT:R-CEL-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Caenorhabditis elegans)
REACT:R-CFA-141422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 converted  to an inhibitory state via interaction with Mad1 (Canis familiaris)
REACT:R-RNO-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Rattus norvegicus)
REACT:R-CEL-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Caenorhabditis elegans)
RHEA:72160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + taurocholate(out) => glutarate(out) + taurocholate(in)
RHEA:44164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O = adenine + D-ribose 5-triphosphate
REACT:R-MMU-9664881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Mus musculus)
RHEA:44858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-(9Z)-octadecenoyl-(R)-carnitine => (9Z)-octadecenoyl-CoA + (R)-carnitine
RHEA:72629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + Zn(2+)(out) => 2 H(+)(out) + Zn(2+)(in)
REACT:R-MMU-983425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Mus musculus)
RHEA:43179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Gallus gallus)
REACT:R-RNO-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Rattus norvegicus)
RHEA:30110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH
RHEA:70555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-galactosamine
REACT:R-HSA-5218916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPK2/3 phosphorylates HSP27 (Homo sapiens)
RHEA:55551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine
RHEA:32741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine
REACT:R-CEL-5661122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2R3-histone H3 (Caenorhabditis elegans)
REACT:R-GGA-5687653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Gallus gallus)
REACT:R-SCE-9674131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 binds ATM dimer:Ub-p-PEX5 (Saccharomyces cerevisiae)
RHEA:60168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty acid kinase"
RHEA:60168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP = a fatty acyl monophosphate + ADP
RHEA:60168	skos:prefLabel	"fatty acid kinase"
GO:0060175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brain-derived neurotrophic factor receptor activity
GO:0060175	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BDNF receptor activity
GO:0060175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDNF-activated receptor activity
GO:0060175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brain-derived neurotrophic factor-activated receptor activity
REACT:R-MMU-6805755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 dimethylates TP53 (Mus musculus)
REACT:R-CEL-2065549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Caenorhabditis elegans)
RHEA:59582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester
RHEA:10666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + perillyl aldehyde => NAD(+) + perillyl alcohol
REACT:R-SSC-351963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A18 transports Gly from extracellular region to cytosol (Sus scrofa)
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type xenobiotic transporter activity
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P-glycoprotein
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multidrug-resistance protein
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	xenobiotic ABC transporter
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pleiotropic-drug-resistance protein
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multidrug resistance exporter
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP phosphohydrolase (xenobiotic-exporting)
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xenobiotic transmembrane transporting ATPase activity
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MDR protein
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled xenobiotic transmembrane transporter activity
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent xenobiotic transmembrane transporter activity
GO:0008559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDR protein
EC:3.2.1.99	skos:prefLabel	"arabinan endo-1,5-alpha-L-arabinosidase"
EC:3.2.1.99	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arabinan endo-1,5-alpha-L-arabinosidase"
EC:3.2.1.99	skos:altLabel	"endo-1,5-alpha-L-arabinanase"
GO:0047002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol 2-dehydrogenase (ribulose forming) activity
GO:0047002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol 2-dehydrogenase activity
RHEA:58399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9618486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-26 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)
REACT:R-MMU-174660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Mus musculus)
REACT:R-BTA-5244692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Bos taurus)
RHEA:50156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine
RHEA:42870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine => norspermine + S-adenosyl 3-(methylsulfanyl)propylamine
RHEA:11352	skos:altLabel	"AK"
RHEA:11352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP = acetyl phosphate + ADP
RHEA:11352	skos:altLabel	"acetic kinase"
RHEA:11352	skos:prefLabel	"acetate kinase"
RHEA:11352	skos:altLabel	"acetokinase"
RHEA:11352	skos:altLabel	"acetate kinase (phosphorylating)"
RHEA:11352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetate kinase"
RHEA:62891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + lactose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)
REACT:R-MMU-71286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Mus musculus)
REACT:R-MMU-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Mus musculus)
REACT:R-XTR-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Xenopus tropicalis)
REACT:R-DRE-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Danio rerio)
GO:0045515	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-18
GO:0045515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-18 receptor binding
GO:0045515	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-18 receptor ligand
REACT:R-CFA-74730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin degradation (Canis familiaris)
REACT:R-PFA-5225649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP7 binds histone H3 (Plasmodium falciparum)
REACT:R-HSA-8873794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCTP binds PC (Homo sapiens)
REACT:R-DME-5693373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)
REACT:R-BTA-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Bos taurus)
RHEA:14807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-allose 6-phosphate + H(+) => ATP + D-allose
REACT:R-HSA-3209096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter (Homo sapiens)
EC:3.5.1.6	skos:prefLabel	"beta-ureidopropionase"
EC:3.5.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-ureidopropionase"
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl carboxypeptidase activity
GO:0009002	skos:altLabel	"DD-peptidase"
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-alanine carboxypeptidase
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl-D-alanine-cleaving peptidase activity
GO:0009002	skos:altLabel	"D-alanyl-D-alanine carboxypeptidase"
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl-D-alanine carboxypeptidase activity
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DD-peptidase activity
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-type D-Ala-D-Ala carboxypeptidase activity
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine-type D-Ala-D-Ala carboxypeptidase"
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DD-transpeptidase activity
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl-D-alanine-carboxypeptidase activity
GO:0009002	skos:altLabel	"DD-transpeptidase"
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl-D-alanine-cleaving-peptidase activity
GO:0009002	skos:prefLabel	"serine-type D-Ala-D-Ala carboxypeptidase"
GO:0009002	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DD-carboxypeptidase
REACT:R-CFA-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
REACT:R-DRE-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Danio rerio)
EC:2.1.1.64	skos:prefLabel	"3-demethylubiquinol 3-O-methyltransferase"
EC:2.1.1.64	skos:altLabel	"3-demethylubiquinone-9 3-methyltransferase"
EC:2.1.1.64	skos:altLabel	"2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase"
EC:2.1.1.64	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-demethylubiquinol 3-O-methyltransferase"
EC:2.1.1.64	skos:altLabel	"5-demethylubiquinone-9 methyltransferase"
GO:0036237	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acyl-glucuronide deglucuronidation activity
GO:0036237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-glucuronidase activity
GO:0140786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine sensor activity
GO:0140786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine sensing activity
RHEA:41502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine
RHEA:35575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Xenopus tropicalis)
RHEA:28386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP
REACT:R-HSA-9692135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)
REACT:R-BTA-9024872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 17(S)-Hp-DHA to PDX (Bos taurus)
RHEA:38750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate
REACT:R-DME-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Drosophila melanogaster)
REACT:R-HSA-5250978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botG LC cleaves target cell VAMP1 (Homo sapiens)
REACT:R-HSA-8956608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)
REACT:R-HSA-5624948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF17 enters the cilium (Homo sapiens)
RHEA:66398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + cholate(out) + glutathione(out) + H(+) + phosphate => ATP + cholate(in) + glutathione(in) + H2O
REACT:R-CFA-211190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of DFF45 (117) (Canis familiaris)
REACT:R-CFA-917888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF binds 2Fe3+ to form holoTF (Canis familiaris)
RHEA:24673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypoxanthine + NAD(+) <=> H(+) + NADH + xanthine
RHEA:72704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose(in) + UMP(out) => UDP-alpha-D-galactose(out) + UMP(in)
RHEA:38184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylaminobutyrate oxidase (demethylating) activity
RHEA:59570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-homocarnosine + phosphate => 4-aminobutanoate + ATP + L-histidine
RHEA:24992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
REACT:R-XTR-8853444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PHLDA1 (Xenopus tropicalis)
REACT:R-RNO-2534388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone Activation Of CatSper (Rattus norvegicus)
REACT:R-MMU-5696670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD1L is recruited to GG-NER site (Mus musculus)
REACT:R-SPO-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Schizosaccharomyces pombe)
GO:0047949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate semialdehyde dehydrogenase (NAD+) activity
GO:0047949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate-semialdehyde dehydrogenase (NAD+) activity
GO:0047949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxopentanoate + H2O + NAD(+) = glutarate + 2 H(+) + NADH
GO:0047949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutarate-semialdehyde:NAD+ oxidoreductase activity
GO:0000252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
GO:0000252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
GO:0000252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C-3 sterol dehydrogenase activity
GO:0000252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
GO:0000252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol 4alpha-carboxylic decarboxylase activity
GO:0000252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C-3 sterol dehydrogenase (C-4 decarboxylase) activity
GO:0000252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
GO:0000252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
GO:0000252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
GO:0000252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
RHEA:44408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)
REACT:R-BTA-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Bos taurus)
REACT:R-HSA-390846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2D3,4 bind to DA (Homo sapiens)
REACT:R-DDI-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Dictyostelium discoideum)
REACT:R-XTR-5357757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC(cIAP1/2) ubiquitinates RIPK1 (Xenopus tropicalis)
GO:0010521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomerase inhibitor activity
REACT:R-SSC-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Sus scrofa)
REACT:R-SSC-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Sus scrofa)
REACT:R-RNO-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Rattus norvegicus)
REACT:R-DRE-9670673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIX is secreted (Danio rerio)
RHEA:11154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+) => 5-pyridoxate + NADPH + O2
RHEA:34833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl-15-methylhexadecasphing-4-enine + phosphate => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate
RHEA:42452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate = H2O + kynurenate
REACT:R-CEL-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Caenorhabditis elegans)
REACT:R-BTA-8952823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Bos taurus)
RHEA:41306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + dodecanoate
REACT:R-HSA-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Homo sapiens)
REACT:R-HSA-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Homo sapiens)
REACT:R-DRE-9624017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SHC1 binds integrin alpha5beta1:fibronectin (Danio rerio)
RHEA:45518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]
REACT:R-XTR-9645414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Xenopus tropicalis)
REACT:R-CFA-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Canis familiaris)
RHEA:42314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 oxidized [adrenodoxin] => H(+) + NADP(+) + 2 reduced [adrenodoxin]
RHEA:61721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-guloside + NAD(+) => a 3-dehydro-D-guloside + H(+) + NADH
RHEA:49737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NAD(+)
REACT:R-RNO-192123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates CHOL (Rattus norvegicus)
REACT:R-RNO-216757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Rattus norvegicus)
RHEA:34393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose
RHEA:25763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-methylmalate + NAD(+) = 3-carboxy-2-oxobutanoate + H(+) + NADH
GO:0106372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity
GO:0106372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H(+) + methanol + O13(4)-desmethyl pFDCC
RHEA:64644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + propanoyl-CoA = butyl propanoate + CoA
RHEA:50878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroxy polyunsaturated fatty acid + H2O + NADP(+) => a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH
RHEA:16805	skos:altLabel	"DAOC hydroxylase"
RHEA:16805	skos:altLabel	"3'-methylcephem hydroxylase"
RHEA:16805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deacetoxycephalosporin-C hydroxylase"
RHEA:16805	skos:altLabel	"DACS"
RHEA:16805	skos:altLabel	"deacetoxycephalosporin C hydroxylase"
RHEA:16805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate
RHEA:16805	skos:prefLabel	"deacetoxycephalosporin-C hydroxylase"
RHEA:16805	skos:altLabel	"deacetylcephalosporin C synthase"
REACT:R-BTA-5213464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is phosphorylated (Bos taurus)
RHEA:16143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-deamino-3''-oxonicotianamine + H(+) + NADH => 2'-deoxymugineate + NAD(+)
REACT:R-DRE-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Danio rerio)
RHEA:61375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O <=> 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate
RHEA:13585	skos:prefLabel	"butyrate kinase"
RHEA:13585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"butyrate kinase"
RHEA:13585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoate = ADP + butanoyl phosphate
REACT:R-BTA-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Bos taurus)
REACT:R-BTA-176101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Rad17-RFC complex to DNA (Bos taurus)
REACT:R-DME-170072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Drosophila melanogaster)
RHEA:58642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine => a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine
REACT:R-XTR-5607741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p52:RELB translocates from cytosol to nucleus (Xenopus tropicalis)
RHEA:67062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asnovolin K + S-adenosyl-L-homocysteine => asnovolin I + S-adenosyl-L-methionine
REACT:R-BTA-9690449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 bind S1P (Bos taurus)
RHEA:48914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GT1a + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a
RHEA:56407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)
REACT:R-BTA-9708430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 (CRM1) binds to BACH1:Hemes (Bos taurus)
RHEA:25991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-8941613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
REACT:R-SSC-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Sus scrofa)
RHEA:71197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + Zn(2+)(in) => H(+)(out) + Zn(2+)(out)
REACT:R-XTR-2161951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Xenopus tropicalis)
GO:0052601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-limonene 1,2-monooxygenase activity
GO:0052601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-limonene,NAD(P)H:oxygen oxidoreductase activity
GO:0052601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-limonene 1,2-monooxygenase activity
GO:0052601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-limonene,NAD(P)H:oxygen oxidoreductase activity
RHEA:20831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2
REACT:R-HSA-6785821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS5,(SOCS1) bind IL4RA (Homo sapiens)
RHEA:12898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-1307963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Danio rerio)
RHEA:28744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(in) + nitrite(out) => nitrate(out) + nitrite(in)
RHEA:43383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-phospho-L-arginyl-[protein] <=> L-arginyl-[protein] + phosphate
REACT:R-SSC-388596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanocortin receptors bind melanocortins (Sus scrofa)
REACT:R-DME-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Drosophila melanogaster)
REACT:R-HSA-1980130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 binds DLK1 (Homo sapiens)
REACT:R-BTA-379382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates DA to DOPAC (Bos taurus)
RHEA:62441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl methyl ester](n) => 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)
RHEA:32155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine
RHEA:32155	skos:prefLabel	"S-adenosylmethionine:tRNA ribosyltransferase-isomerase"
RHEA:32155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-adenosylmethionine:tRNA ribosyltransferase-isomerase"
RHEA:32155	skos:altLabel	"queuosine biosynthesis protein QueA"
REACT:R-RNO-4755419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1H4 with SUMO1 (Rattus norvegicus)
REACT:R-SSC-1606602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Sus scrofa)
REACT:R-RNO-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Rattus norvegicus)
RHEA:64534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-BTA-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Bos taurus)
RHEA:41476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + zymosterol = CoA + zymosterol ester
RHEA:12820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydrobiochanin A + NADP(+) <=> biochanin A + 2 H(+) + NADPH
REACT:R-HSA-6814778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDPD3 hydrolyzes LysoPtdCho (Homo sapiens)
RHEA:52013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
RHEA:30133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[ACP] + octanoate => H2O + octanoyl-[ACP]
RHEA:38983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)
GO:0008404	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2C39
GO:0008404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonic acid 14,15-epoxygenase activity
GO:0008404	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2C29
GO:0008404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)
REACT:R-DRE-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Danio rerio)
RHEA:26535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate
REACT:R-XTR-8987202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)
REACT:R-SPO-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Schizosaccharomyces pombe)
RHEA:61084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + 2-oxoglutarate + O2 = (2R,3R)-dihydrokaempferol + CO2 + succinate
REACT:R-RNO-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Rattus norvegicus)
REACT:R-CEL-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Caenorhabditis elegans)
RHEA:55677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + NH4(+) => (2S)-2-amino-4-deoxychorismate + H2O
RHEA:13267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine
REACT:R-CFA-190065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TrkA receptor internalizes to endosomes (Canis familiaris)
REACT:R-SCE-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Saccharomyces cerevisiae)
REACT:R-MMU-388855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin-releasing hormone receptor binds PRH (Mus musculus)
REACT:R-MMU-9625813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P binds S1PR3 in response to E2 stimulation (Mus musculus)
REACT:R-BTA-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Bos taurus)
RHEA:18064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran <=> methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin
REACT:R-DME-109813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1 binds SOS1 (Drosophila melanogaster)
RHEA:45050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + NH4(+) => acetamide + H2O
RHEA:24213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(2-hydroxyethyl)-4-methylthiazole + ATP => 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)
REACT:R-MMU-264976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Mus musculus)
RHEA:36164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate => ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate
REACT:R-CEL-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Caenorhabditis elegans)
REACT:R-HSA-9021170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen stimulates dimerization of plasma membrane estrogen receptors (Homo sapiens)
REACT:R-DRE-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Danio rerio)
RHEA:46473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:40903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine
REACT:R-MMU-8866268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADBRK1,2 phosphorylate AVPR2 (Mus musculus)
REACT:R-RNO-8853762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET dimerizes (Rattus norvegicus)
GO:0102812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity
REACT:R-HSA-442732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMDA-activated RASGRF1 activates RAS (Homo sapiens)
RHEA:33863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-7 + succinate = fumarate + menaquinol-7
REACT:R-HSA-9683656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA4 is translated to protein E (Homo sapiens)
REACT:R-HSA-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Homo sapiens)
REACT:R-GGA-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Gallus gallus)
RHEA:64410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in) => H(+)(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out)
RHEA:62143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + GTP <=> dTDP + GDP
REACT:R-GGA-9708558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Gallus gallus)
REACT:R-BTA-5138433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Bos taurus)
RHEA:49363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',2'-dihydroxy-2-oxospirilloxanthin <=> 2,2'-dioxospirilloxanthin + H2O
REACT:R-RNO-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Rattus norvegicus)
RHEA:66131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-phenylalanine <=> (2S)-2-aminobutanoate + 3-phenylpyruvate
RHEA:49888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2
RHEA:49888	skos:prefLabel	"dihydrophenazinedicarboxylate synthase"
RHEA:49888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrophenazinedicarboxylate synthase"
GO:0047998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hyoscyamine (6S)-hydroxylase activity
GO:0047998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hyoscyamine 6-beta-hydroxylase activity
GO:0047998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hyoscyamine 6beta-hydroxylase activity
GO:0047998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hyoscyamine 6-hydroxylase activity
GO:0047998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)
GO:0047998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyoscyamine (6S)-dioxygenase activity
GO:0047998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hyoscyamine 6beta-dioxygenase activity
REACT:R-RNO-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Rattus norvegicus)
RHEA:70935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(in) = L-lysine(out)
REACT:R-GGA-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Gallus gallus)
RHEA:66447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-3-one + NADP(+) <=> (E)-4-hexen-3-one + H(+) + NADPH
RHEA:18045	skos:altLabel	"alpha-glucose-1-phosphate phosphodiesterase"
RHEA:18045	skos:prefLabel	"glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase"
RHEA:18045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase"
RHEA:18045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O = alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)
RHEA:33680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine
REACT:R-DME-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Drosophila melanogaster)
REACT:R-GGA-5607002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor VIIIa (Gallus gallus)
RHEA:34706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (E)-2-epi-beta-caryophyllene + diphosphate
RHEA:42277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA
REACT:R-CFA-204779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang1 (Canis familiaris)
RHEA:41202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate
REACT:R-BTA-5578966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A:AGO2:miRNA is transported into the nucleus (Bos taurus)
REACT:R-CEL-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Caenorhabditis elegans)
REACT:R-MMU-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Mus musculus)
RHEA:28120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP => di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose
RHEA:20213	skos:prefLabel	"octanoyl-[GcvH]:protein N-octanoyltransferase"
RHEA:20213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"octanoyl-[GcvH]:protein N-octanoyltransferase"
RHEA:20213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]
REACT:R-RNO-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Rattus norvegicus)
RHEA:46583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 <=> 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetracosanoyl-CoA => CoA + H(+) + tetracosanoate
RHEA:11457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:37410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA
RHEA:44860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-dimethylnonanoyl-(R)-carnitine
EC:4.1.2.61	skos:prefLabel	"feruloyl-CoA hydratase/lyase"
EC:4.1.2.61	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"feruloyl-CoA hydratase/lyase"
GO:0004334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fumarylacetoacetate hydrolase activity
GO:0004334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-diketonase activity
GO:0004334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetase activity
GO:0004334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-fumarylacetoacetate fumarylhydrolase activity
RHEA:25555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate <=> diphosphate + stemar-13-ene
GO:0004594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pantothenate kinase activity
GO:0004594	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantothenate kinase (phosphorylating) activity
GO:0004594	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:pantothenate 4'-phosphotransferase activity
GO:0004594	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:(R)-pantothenate 4'-phosphotransferase activity
GO:0004594	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantothenic acid kinase activity
GO:0004594	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-pantothenate kinase activity
REACT:R-HSA-264458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of COP1 (Homo sapiens)
REACT:R-MMU-5654662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)
RHEA:48071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)) + H2O <=> ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate
REACT:R-XTR-5099886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binding to FZD promotes PRICKLE1 degradation (Xenopus tropicalis)
REACT:R-GGA-5675470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC2/3 (cIAP1/2) is autoubiquitinated (Gallus gallus)
REACT:R-MMU-190682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin synthesis (generic) (Mus musculus)
GO:0102331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptadecanoyl-[acp] elongase/decarboxylase activity
REACT:R-HSA-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Homo sapiens)
GO:0036307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23S rRNA (adenine(2030)-N(6))-methyltransferase activity
REACT:R-BTA-6786050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Bos taurus)
RHEA:58090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+) => 1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O
RHEA:13426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine ribonucleoside 5'-phosphate + H2O => a pyrimidine nucleobase + D-ribose 5-phosphate
REACT:R-CEL-5672972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
REACT:R-BTA-9733964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Bos taurus)
REACT:R-GGA-6805640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates KAT6A (Gallus gallus)
RHEA:55212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-hydroxyhexadecanoyl-CoA = formyl-CoA + pentadecanal
REACT:R-HSA-5250947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH complex binds rDNA promoter (Homo sapiens)
GO:0103071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase activity
RHEA:43545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tyramine => ADP + gamma-L-glutamyltyramine + H(+) + phosphate
REACT:R-SPO-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Schizosaccharomyces pombe)
RHEA:34887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenate(in) = selenate(out)
REACT:R-RNO-6800798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome binds CASP2 (Rattus norvegicus)
RHEA:39746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)
RHEA:29043	skos:altLabel	"flavin dependent thymidylate synthase"
RHEA:29043	skos:altLabel	"FDTS"
RHEA:29043	skos:prefLabel	"thymidylate synthase (FAD)"
RHEA:29043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)
RHEA:29043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thymidylate synthase (FAD)"
REACT:R-BTA-194187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-XTR-8865237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD6 methylates RELA in the NFkB complex (Xenopus tropicalis)
GO:0001847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	opsonin receptor activity
REACT:R-MMU-4332363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation and activation of CAMK2 (Mus musculus)
RHEA:15507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formylglutarate + H(+) + NADH => (S)-2-hydroxymethylglutarate + NAD(+)
EC:6.3.2.17	skos:altLabel	"FPGS"
EC:6.3.2.17	skos:altLabel	"folate polyglutamate synthetase"
EC:6.3.2.17	skos:altLabel	"tetrahydrofolylpolyglutamate synthase"
EC:6.3.2.17	skos:altLabel	"folylpoly(gamma-glutamate) synthase"
EC:6.3.2.17	skos:altLabel	"tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)"
EC:6.3.2.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrahydrofolate synthase"
EC:6.3.2.17	skos:altLabel	"folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase"
EC:6.3.2.17	skos:prefLabel	"tetrahydrofolate synthase"
EC:6.3.2.17	skos:altLabel	"formyltetrahydropteroyldiglutamate synthetase"
EC:6.3.2.17	skos:altLabel	"N(10)-formyltetrahydropteroyldiglutamate synthetase"
EC:6.3.2.17	skos:altLabel	"folylpoly-gamma-glutamate synthase"
EC:6.3.2.17	skos:altLabel	"folylpolyglutamate synthetase"
EC:6.3.2.17	skos:altLabel	"folylpolyglutamate synthase"
EC:6.3.2.17	skos:altLabel	"folylpolyglutamyl synthetase"
REACT:R-CFA-909724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IFNAR1 (Canis familiaris)
REACT:R-CFA-3928612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KALRN exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
REACT:R-BTA-164620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Bos taurus)
RHEA:54196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:10508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate
REACT:R-BTA-390250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Bos taurus)
RHEA:30646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + S-methyl-5'-thioinosine <=> hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
REACT:R-CFA-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Canis familiaris)
RHEA:46553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:17245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxyanthranilate oxidase"
RHEA:17245	skos:altLabel	"3-hydroxyanthranilic acid oxidase"
RHEA:17245	skos:prefLabel	"3-hydroxyanthranilate oxidase"
RHEA:17245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2
RHEA:69731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + phenylacetyl-AMP = AMP + H(+) + phenylacetyl-CoA
REACT:R-BTA-6797961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHDH oxidises Cho to BETALD (Bos taurus)
RHEA:16760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + trypanothione <=> H(+) + NADPH + trypanothione disulfide
RHEA:13540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)
GO:0052608	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-ring carotenoid 3-hydroxylase activity
GO:0052608	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carotene beta-ring hydroxylase activity
GO:0052608	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-carotene hydroxylase activity
GO:0052608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	echinenone 3-hydroxylase activity
REACT:R-RNO-9734070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET recombinant therapeutic antibodies bind MET (Rattus norvegicus)
REACT:R-DDI-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Dictyostelium discoideum)
REACT:R-CEL-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Caenorhabditis elegans)
RHEA:57223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GTP
REACT:R-HSA-168893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of NEP/NS2 to vRNP:M1 (Homo sapiens)
RHEA:33922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + lanosterol + NADPH <=> 24,25-dihydrolanosterol + NADP(+)
REACT:R-RNO-4641260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL1 is degraded by the proteasome (Rattus norvegicus)
REACT:R-SSC-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Sus scrofa)
GO:0043024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosomal small subunit binding
REACT:R-CEL-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Caenorhabditis elegans)
REACT:R-GGA-9708423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1:BACH1:Hemes are transported out of the nucleus (Gallus gallus)
REACT:R-SSC-9707690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 binds MAFK (Sus scrofa)
REACT:R-HSA-976768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3b (Homo sapiens)
RHEA:40675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine = 2-aminobut-2-enoate + H2O
RHEA:44055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA
REACT:R-DRE-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Danio rerio)
REACT:R-RNO-9653503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B is phosphorylated on serine 181 (Rattus norvegicus)
RHEA:50936	skos:prefLabel	"3-aminobutanoyl-CoA transaminase"
RHEA:50936	skos:altLabel	"acyl-CoA beta-transaminase"
RHEA:50936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate
RHEA:50936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-aminobutanoyl-CoA transaminase"
RHEA:41988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH
REACT:R-XTR-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Xenopus tropicalis)
REACT:R-DRE-4411402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NLK (Danio rerio)
REACT:R-DDI-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Dictyostelium discoideum)
RHEA:67807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 <=> CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate
REACT:R-DDI-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Dictyostelium discoideum)
RHEA:15538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate + NADP(+) => 3-sulfopyruvate + H(+) + NADPH
REACT:R-HSA-8864989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A homodimer binds the TGFA gene promoter (Homo sapiens)
RHEA:35825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromethanopterin + H(+) + NADH => 5,6,7,8-tetrahydromethanopterin + NAD(+)
REACT:R-BTA-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)
RHEA:14110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NADP(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADPH
REACT:R-HSA-5654672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR1 (Homo sapiens)
REACT:R-CFA-3322014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-a (Canis familiaris)
REACT:R-HSA-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Homo sapiens)
REACT:R-BTA-909719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STAT2 to p-IFNAR1 (Bos taurus)
RHEA:54554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O
REACT:R-CFA-3928627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB phosphorylates TIAM1 (Canis familiaris)
RHEA:37361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine 6-phosphate(in) + L-histidyl-[protein] => D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein]
RHEA:27464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glycero-alpha-D-manno-heptose
REACT:R-RNO-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Rattus norvegicus)
RHEA:15964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> H(+) + taxiphyllin + UDP
GO:0008405	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2C38
GO:0008405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0008405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonic acid 11,12-epoxygenase activity
RHEA:16052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide-GDP + alpha-ribazole <=> adenosylcob(III)alamin + GMP + H(+)
RHEA:31318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GDP-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)
RHEA:62434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine => a uridine in tRNA + S-adenosyl-L-methionine
REACT:R-RNO-9658445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Rattus norvegicus)
RHEA:34757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + N-acyl-15-methylhexadecasphing-4-enine => H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine
RHEA:72090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurodeoxycholate(out) <=> 2 Na(+)(in) + taurodeoxycholate(in)
REACT:R-BTA-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Bos taurus)
RHEA:15880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + pyridoxamine 5'-phosphate <=> D-glutamate + pyridoxal 5'-phosphate
REACT:R-DRE-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Danio rerio)
RHEA:72637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine => 6-hydroxy-1-methoxyphenazine N(5)-oxide + S-adenosyl-L-methionine
RHEA:21661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H2O + NADP(+) => benzoate + 2 H(+) + NADPH
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK6
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[myosin heavy-chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:myosin-heavy-chain O-phosphotransferase activity
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	calmodulin-dependent myosin heavy chain kinase activity
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[myosin heavy-chain] kinase"
GO:0016905	skos:altLabel	"MHCK"
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myosin I heavy chain kinase activity
GO:0016905	skos:altLabel	"calmodulin-dependent myosin heavy chain kinase"
GO:0016905	skos:prefLabel	"[myosin heavy-chain] kinase"
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myosin I heavy-chain kinase activity
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin heavy chain kinase activity
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myosin II heavy chain kinase activity
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MHCK
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin heavy-chain kinase activity
GO:0016905	skos:altLabel	"myosin heavy chain kinase"
GO:0016905	skos:altLabel	"MIHC kinase"
GO:0016905	skos:altLabel	"myosin I heavy-chain kinase"
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin-heavy-chain kinase activity
GO:0016905	skos:altLabel	"myosin heavy chain kinase A"
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myosin II heavy-chain kinase activity
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:myosin heavy-chain O-phosphotransferase activity
GO:0016905	skos:altLabel	"myosin heavy-chain kinase"
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MIHC kinase activity
GO:0016905	skos:altLabel	"myosin II heavy-chain kinase"
GO:0016905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin heavy chain kinase A activity
REACT:R-DME-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Drosophila melanogaster)
REACT:R-MMU-1676005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Mus musculus)
REACT:R-SCE-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Saccharomyces cerevisiae)
REACT:R-CFA-1678708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(2) (Canis familiaris)
REACT:R-DME-209361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT92E binds to phosphorylated HOP and phosphorylated DOME (Drosophila melanogaster)
REACT:R-GGA-9618378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 binds the Nup107-Nup160 complex (Gallus gallus)
REACT:R-MMU-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Mus musculus)
REACT:R-HSA-2028583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS2 (Homo sapiens)
RHEA:20957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + ATP + CoA => AMP + diphosphate + phenylacetyl-CoA
RHEA:18426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-quinate + NADP(+) => 3-dehydroquinate + H(+) + NADPH
RHEA:19889	skos:prefLabel	"UTP--glucose-1-phosphate uridylyltransferase"
RHEA:19889	skos:altLabel	"UDP-glucose diphosphorylase"
RHEA:19889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UTP--glucose-1-phosphate uridylyltransferase"
RHEA:19889	skos:altLabel	"glucose-1-phosphate uridylyltransferase"
RHEA:19889	skos:altLabel	"UDP-glucose pyrophosphorylase"
RHEA:19889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose
REACT:R-BTA-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Bos taurus)
RHEA:35698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-versiconol acetate + NADP(+) <=> (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH
REACT:R-CFA-5691150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFR2 dimer binds 2xholoTF (Canis familiaris)
REACT:R-DRE-3222259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF20 binds TP53 dimethylated on K370 and K382 (Danio rerio)
RHEA:31413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine
RHEA:37721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA
RHEA:42073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z)-2-oxohept-4-enedioate + H2O => (4S)-4-hydroxy-2-oxoheptanedioate
REACT:R-MMU-205112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Mus musculus)
RHEA:24563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-serine <=> CoA + O-acetyl-L-serine
REACT:R-GGA-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Gallus gallus)
REACT:R-BTA-5671707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Bos taurus)
REACT:R-CEL-9648268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A antagonists (Caenorhabditis elegans)
REACT:R-BTA-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Bos taurus)
RHEA:41971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) <=> a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)
REACT:R-DME-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)
REACT:R-MMU-174235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdc20 (Mus musculus)
RHEA:46056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:68797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + H2O => alpha-D-glucose + D-glucose
REACT:R-CFA-2066299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 binds phosphorylated WWTR1 (TAZ) (Canis familiaris)
RHEA:44404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-7 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-7
GO:0120285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine sensing activity
GO:0120285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine sensor activity
RHEA:22062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine
REACT:R-CFA-3215406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds WDR77 (Canis familiaris)
REACT:R-DRE-9027624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DHA to 7-HDHA (Danio rerio)
REACT:R-MMU-3221982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANP binds TP53 (Mus musculus)
RHEA:42063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + NAD(+) <=> 11-cis-retinal + H(+) + NADH
RHEA:40471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-methylpentadecanoyl-CoA + O2 = 2-methyl-(2E)-pentadecenoyl-CoA + H2O2
RHEA:41899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + tetradecanoyl-[ACP]
RHEA:22330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + thiamine phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+)
RHEA:65211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA + H2O <=> (S)-3-hydroxybutanoate + CoA + H(+)
REACT:R-MMU-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Mus musculus)
REACT:R-MMU-982768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GH:GHR:JAK2 complex undergoes a conformational change (Mus musculus)
REACT:R-DDI-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Dictyostelium discoideum)
RHEA:70069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:19060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxy polyunsaturated fatty acid + 2 glutathione <=> a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O
RHEA:12530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[hyaluronan](n+1) + H(+) + UDP => N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate
REACT:R-RNO-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Rattus norvegicus)
REACT:R-SSC-2984226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NEK9 (Sus scrofa)
RHEA:68151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octanone + H(+) + NADPH <=> (2R)-octan-2-ol + NADP(+)
REACT:R-HSA-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Homo sapiens)
REACT:R-HSA-8849353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Homo sapiens)
RHEA:50518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-threonyl-[protein]
RHEA:10893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate + NAD(+) => (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH
RHEA:38827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-GGA-5615637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Gallus gallus)
RHEA:58945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH => 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)
REACT:R-DRE-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Danio rerio)
GO:0098988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled glutamate receptor activity
GO:0098988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled glutamate receptor activity
REACT:R-BTA-2168897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP1 (CD91) binds Hemopexin:heme (Bos taurus)
REACT:R-SPO-804969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B1 hydrogenates E1 to EST17b (Schizosaccharomyces pombe)
REACT:R-HSA-8856525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANGPTL8 binds ANGPTL3 (Homo sapiens)
REACT:R-CFA-8869667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxLDL:CD36 binds TLR4:TLR6 (Canis familiaris)
RHEA:33505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + itraconazole(out) + phosphate => ATP + H2O + itraconazole(in)
REACT:R-DRE-8953115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds to MGA:MAX (Danio rerio)
RHEA:69965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone => 6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:45885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-HSA-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Homo sapiens)
RHEA:51534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyisourate + H2O + NADP(+) => H(+) + NADPH + O2 + urate
REACT:R-BTA-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Bos taurus)
RHEA:62365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-N(5)-peroxide + thymine => (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)
RHEA:45237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-202489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of Bcl10 (Sus scrofa)
RHEA:63869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 => (2R,9Z)-2-hydroperoxyoctadecenoate
RHEA:38790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-BTA-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Bos taurus)
REACT:R-XTR-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Xenopus tropicalis)
REACT:R-BTA-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Bos taurus)
RHEA:11251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O <=> (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)
REACT:R-BTA-8849348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Bos taurus)
RHEA:55623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carotenoid psi-end group <=> a carotenoid beta-end derivative
RHEA:16539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10S)-9,10-dihydroxyoctadecanoate + phosphate => (9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O
REACT:R-GGA-8854604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D16 accelerates GTP hydrolysis by RAB4A (Gallus gallus)
RHEA:21862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate => 3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate
RHEA:38860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP
REACT:R-DRE-9014434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GAPs stimulate RHOG GTPase activity (Danio rerio)
REACT:R-GGA-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Gallus gallus)
GO:0042557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eEF-2 kinase activator
GO:0042557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eukaryotic elongation factor-2 kinase activator activity
REACT:R-DRE-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Danio rerio)
RHEA:16123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(carbamoylamino)propanoate + H(+) => 5,6-dihydrouracil + H2O
RHEA:47944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranyl diphosphate phosphohydrolase"
RHEA:47944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate
RHEA:47944	skos:prefLabel	"geranyl diphosphate phosphohydrolase"
RHEA:38997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + choline + H(+) => a 1-acyl-sn-glycero-3-phosphocholine + H2O
REACT:R-CFA-171106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex => LDLR + LDL (Canis familiaris)
REACT:R-CFA-5634750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Canis familiaris)
GO:0005009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin receptor activity
GO:0005009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin-activated receptor activity
REACT:R-SSC-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Sus scrofa)
REACT:R-DDI-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)
RHEA:30610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-phytofluene <=> AH2 + all-trans-zeta-carotene
RHEA:61731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-dehydro-D-guloside <=> a 3-dehydro-D-glucoside
REACT:R-CFA-5668605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2:GTP binds NOX2 complex (Canis familiaris)
GO:0033229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine transmembrane transporter activity
REACT:R-CEL-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Caenorhabditis elegans)
REACT:R-CEL-1482695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Caenorhabditis elegans)
GO:0033829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity
GO:0033829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity
GO:0033829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
REACT:R-HSA-5603062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complexed PIWIL2 binds  pre-piRNA (Homo sapiens)
RHEA:59442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (-)-dehydrodiconiferyl alcohol + H(+) + NADPH
RHEA:45078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:20668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-glucitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH
REACT:R-BTA-379048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)
REACT:R-HSA-216076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Homo sapiens)
REACT:R-MMU-5604929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C binds Protein S (Mus musculus)
GO:0034898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecyltrimethylammonium chloride monooxygenase activity
REACT:R-MMU-140870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Mus musculus)
RHEA:16164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[leghemoglobin] + NADH <=> 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)
REACT:R-HSA-1614336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)
RHEA:70750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
GO:0034073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahymanol cyclase activity
RHEA:70472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 => a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate
REACT:R-RNO-3257122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Rattus norvegicus)
REACT:R-BTA-1678923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR folding by chaperones GP96 and CNPY3 (Bos taurus)
RHEA:61265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanine + O2 => H2O2 + NH4(+) + pyruvate
REACT:R-BTA-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Bos taurus)
REACT:R-MMU-9008271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Mus musculus)
EC:3.2.2.15	skos:altLabel	"DNA-deoxyinosine glycosidase"
EC:3.2.2.15	skos:prefLabel	"DNA-deoxyinosine glycosylase"
EC:3.2.2.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA-deoxyinosine glycosylase"
EC:3.2.2.15	skos:altLabel	"DNA(hypoxanthine) glycohydrolase"
RHEA:53292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin = H(+) + N-carbamoyl-L-methionine
REACT:R-MMU-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Mus musculus)
RHEA:20899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + urea <=> ADP + H(+) + phosphate + urea-1-carboxylate
REACT:R-MMU-9757578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDN (Mus musculus)
REACT:R-CEL-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Caenorhabditis elegans)
REACT:R-XTR-6784598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPPA(124-151) binds NPR1 (Xenopus tropicalis)
GO:0140802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide
GO:0140802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity
RHEA:63313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 => 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate
REACT:R-MMU-917811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3-like proteins reduce Fe3+ to Fe2+ (Mus musculus)
REACT:R-DRE-5662608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds cadmium (Danio rerio)
REACT:R-BTA-8948234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB:4-Hyp collagen propeptides dissociates (Bos taurus)
GO:0016517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-12R
GO:0016517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-12 receptor activity
GO:0016517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-12 receptor activity
RHEA:20467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP => [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine
RHEA:51260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypoxanthine + NAD(+) => H(+) + NADH + xanthine
REACT:R-HSA-399942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plexin-A1-4 binds NRP1 (Homo sapiens)
REACT:R-RNO-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Rattus norvegicus)
REACT:R-RNO-6799202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Rattus norvegicus)
REACT:R-BTA-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Bos taurus)
RHEA:31827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-gamma-cadinene + diphosphate
RHEA:31827	skos:prefLabel	"(+)-gamma-cadinene synthase"
RHEA:31827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-gamma-cadinene synthase"
RHEA:72758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP <=> 3',3',3'-c-tri-AMP + 3 diphosphate
GO:0120230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	recombinase activator activity
REACT:R-SSC-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Sus scrofa)
REACT:R-SSC-3323013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
GO:0048038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinone binding
REACT:R-XTR-445699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Xenopus tropicalis)
RHEA:16188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + NAD(+) <=> a carboxylate + 2 H(+) + NADH
REACT:R-XTR-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Xenopus tropicalis)
RHEA:39185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH
REACT:R-GGA-352981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + H2O <=> 2-phosphoglycerate (Gallus gallus)
RHEA:19870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + glycine => an N-acylglycine + CoA + H(+)
RHEA:68342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-sulfopantetheine + phosphate => (R)-4'-phospho-S-sulfopantetheine + H2O
REACT:R-MMU-8937419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBR3 reduces DOX to DOXOL (Mus musculus)
RHEA:44865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)
REACT:R-CFA-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Canis familiaris)
RHEA:50221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-demethyl-4-deoxygadusol => (R)-demethyl-4-deoxygadusol
GO:0050528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyloxyacyl hydrolase activity
REACT:R-DRE-2465924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1LW binds 11cRAL (Danio rerio)
RHEA:53949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[BtrI ACP] + L-glutamate => ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate
RHEA:45514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit]
REACT:R-MMU-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Mus musculus)
REACT:R-HSA-422048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acyl Ghrelin and C-Ghrelin are secreted (Homo sapiens)
RHEA:36160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-BTA-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Bos taurus)
REACT:R-SSC-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Sus scrofa)
RHEA:58213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-2186767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SKI/SKIL (Danio rerio)
REACT:R-HSA-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Homo sapiens)
REACT:R-HSA-9635918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CEBPB in response to stress (Homo sapiens)
REACT:R-XTR-202541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Xenopus tropicalis)
REACT:R-XTR-375340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 62 mediated neuronal gap junction communication (Xenopus tropicalis)
REACT:R-DRE-1250383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Danio rerio)
REACT:R-CFA-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Canis familiaris)
RHEA:17229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an aliphatic alcohol = an acetyl ester + CoA
RHEA:17229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol O-acetyltransferase"
RHEA:17229	skos:altLabel	"AATASE"
RHEA:17229	skos:prefLabel	"alcohol O-acetyltransferase"
REACT:R-DRE-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Danio rerio)
REACT:R-SPO-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Schizosaccharomyces pombe)
REACT:R-HSA-2684507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2, 4, (3) bind FGF2 (Homo sapiens)
REACT:R-DRE-1295609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates SPRY2 on Y55 and Y227 (Danio rerio)
RHEA:43406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP => N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose
REACT:R-DDI-2161950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Dictyostelium discoideum)
REACT:R-SSC-448703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family precursors are cleaved by caspase-1 (Sus scrofa)
REACT:R-HSA-5692934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACE1 binds GGA1,2,3 (Homo sapiens)
REACT:R-DME-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Drosophila melanogaster)
RHEA:21226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + sphing-4-enine-phosphocholine => CDP-choline + sphing-4-enine
REACT:R-HSA-1462041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNP1-4 are released into phagocytic vacuoles (Homo sapiens)
REACT:R-SSC-8852874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 binds C3d, C3dg, iC3b (Sus scrofa)
RHEA:37766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DME-9755303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades HIFalpha (Drosophila melanogaster)
REACT:R-CFA-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
REACT:R-SSC-936942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Sus scrofa)
REACT:R-BTA-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Bos taurus)
REACT:R-CFA-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Canis familiaris)
RHEA:20697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 superoxide => H2O2 + O2
REACT:R-GGA-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Gallus gallus)
REACT:R-XTR-193997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B1 oxidises 11DCORT (Xenopus tropicalis)
REACT:R-RNO-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Rattus norvegicus)
REACT:R-MMU-8940554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2 cleaves OPTC (Mus musculus)
REACT:R-MMU-9023968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Mus musculus)
GO:1990915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of ascospore wall
REACT:R-RNO-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Rattus norvegicus)
REACT:R-HSA-418866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPalpha binds DCC (Homo sapiens)
REACT:R-HSA-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Homo sapiens)
REACT:R-DRE-5654587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS phosphorylates PPTN11 (Danio rerio)
REACT:R-DME-209158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polymeric PGN bound PGRP-LCx multimerises at the plasma membrane (Drosophila melanogaster)
REACT:R-BTA-5618105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)
REACT:R-DRE-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Danio rerio)
RHEA:71840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) => dehydroepiandrosterone 3-sulfate(in)
REACT:R-CFA-5649664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyG from damaged DNA (Canis familiaris)
GO:0043777	skos:prefLabel	"cobalt-precorrin-7 (C(5))-methyltransferase"
GO:0043777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	precorrin-6Y methylase
GO:0043777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	precorrin-6 methyltransferase
GO:0043777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin-7 C15-methyltransferase activity
GO:0043777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobalt-precorrin-7 (C(5))-methyltransferase"
GO:0043777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin 7 C15-methyltransferase activity
GO:0043777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-7 + S-adenosyl-L-methionine = Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine
GO:0043777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	precorrin-6Y C5,15-methyltransferase (decarboxylating)
RHEA:52730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate
RHEA:23482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylmaleate => 2-methylene-3-methylsuccinate
GO:0099099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein gated ion channel activity
GO:0050638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxadien-5-alpha-ol O-acetyltransferase activity
GO:0050638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity
GO:0050638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxadien-5alpha-ol O-acetyltransferase activity
GO:0050638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity
GO:0050638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity
GO:0050638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxadienol acetyltransferase activity
GO:0050638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxadien-5a-ol O-acetyltransferase activity
GO:0050638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity
REACT:R-RNO-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Rattus norvegicus)
RHEA:62940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-acetylcytosine = acetate + cytosine + H(+)
REACT:R-XTR-2065549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Xenopus tropicalis)
REACT:R-CFA-9708866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-F2R binds vorapaxar (Canis familiaris)
REACT:R-CFA-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Canis familiaris)
RHEA:72117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(in) + Na(+)(in) => glycine betaine(out) + Na(+)(out)
GO:0009882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	blue light photoreceptor activity
REACT:R-DRE-3209159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERF translocates to the cytosol (Danio rerio)
RHEA:31207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + hexanoyl-CoA = (2E)-hexenoyl-CoA + FADH2
GO:0018111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine racemase activity
RHEA:54334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline
REACT:R-CFA-5218818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Canis familiaris)
RHEA:29668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O(in) => H2O(out)
REACT:R-HSA-2660819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 (Homo sapiens)
RHEA:13201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-arginine = guanidinoacetate + L-ornithine
RHEA:13201	skos:prefLabel	"glycine amidinotransferase"
RHEA:13201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine amidinotransferase"
REACT:R-RNO-8874206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L3 (Rattus norvegicus)
REACT:R-DRE-8983996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Danio rerio)
RHEA:21027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glyoxylate + NADP(+) <=> H(+) + NADPH + oxalyl-CoA
RHEA:37262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + H2O + NAD(+) <=> 2-oxobutanoate + H(+) + NADH + NH4(+)
REACT:R-HSA-9705082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 nsp13 binds TBK1 (Homo sapiens)
RHEA:18106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate
REACT:R-RNO-8855381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
REACT:R-SPO-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Schizosaccharomyces pombe)
GO:0043880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR
GO:0043880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonyl-coenzyme A reductase activity
GO:0043880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonyl-CoA reductase activity
REACT:R-BTA-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Bos taurus)
RHEA:56021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)
REACT:R-DRE-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Danio rerio)
GO:0018617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity
GO:0018617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity
REACT:R-XTR-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Xenopus tropicalis)
RHEA:35659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose = GDP + H(+) + mannosylinositol phosphorylphytoceramide
REACT:R-GGA-2060328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS1 (Gallus gallus)
GO:0015666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	restriction endodeoxyribonuclease activity
GO:0015666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	restriction enzyme activity
GO:0015666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	restriction endonuclease activity
RHEA:47778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine
REACT:R-MMU-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Mus musculus)
REACT:R-MMU-2984226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NEK9 (Mus musculus)
RHEA:53693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O => H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine
RHEA:49499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane
RHEA:23668	skos:prefLabel	"biotin--[methylmalonyl-CoA-carboxytransferase] ligase"
RHEA:23668	skos:altLabel	"biotin--[methylmalonyl-CoA-carboxyltransferase] ligase"
RHEA:23668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biotin--[methylmalonyl-CoA-carboxytransferase] ligase"
RHEA:23668	skos:altLabel	"biotin-transcarboxylase synthetase"
RHEA:23668	skos:altLabel	"biotin--[methylmalonyl-CoA-carboxytransferase] synthetase"
RHEA:23668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin = AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]
RHEA:23668	skos:altLabel	"biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase"
REACT:R-HSA-9665702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 TMD/JMD mutants bind TKIs (Homo sapiens)
RHEA:24481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol
GO:0008395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid hydroxylase activity
GO:0008395	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2G1
GO:0008395	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	olfactory-specific steroid hydroxylase activity
REACT:R-XTR-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Xenopus tropicalis)
RHEA:30548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O
GO:0047156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin-ribose-5-phosphate transaldolase activity
GO:0047156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-deoxy-D-altro-heptulose-7-phosphate synthase activity
GO:0047156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-deoxy-D-altro-heptulose-7-phosphate synthetase activity
GO:0047156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity
GO:0047156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity
REACT:R-DDI-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Dictyostelium discoideum)
REACT:R-MMU-9714363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC translocates to the endoplasmic reticulum membrane (Mus musculus)
REACT:R-GGA-977359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to membrane-associated Factor H:C3b (Gallus gallus)
REACT:R-HSA-2426154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the LSS promoter (Homo sapiens)
REACT:R-SSC-9018859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Sus scrofa)
RHEA:56290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:11584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine = D-ornithine
RHEA:11584	skos:prefLabel	"ornithine racemase"
RHEA:11584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ornithine racemase"
EC:3.2.1.151	skos:altLabel	"XEG"
EC:3.2.1.151	skos:altLabel	"xyloglucanendohydrolase"
EC:3.2.1.151	skos:altLabel	"xyloglucan endo-beta-1,4-glucanase"
EC:3.2.1.151	skos:prefLabel	"xyloglucan-specific endo-beta-1,4-glucanase"
EC:3.2.1.151	skos:altLabel	"xyloglucanase"
EC:3.2.1.151	skos:altLabel	"1,4-beta-D-glucan glucanohydrolase"
EC:3.2.1.151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xyloglucan-specific endo-beta-1,4-glucanase"
RHEA:29131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + nitrate = H2O + menaquinone-8 + nitrite
REACT:R-CEL-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Caenorhabditis elegans)
GO:0034937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	perchlorate reductase activity
RHEA:62030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + stigmasterol => H2O + stigmasteryl 3-beta-D-glucoside
REACT:R-HSA-9760128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2-dependent GSTA1 gene expression (Homo sapiens)
REACT:R-BTA-9035227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN2 binds CysS248-MPST (Bos taurus)
RHEA:70039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:62015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Caenorhabditis elegans)
REACT:R-BTA-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)
RHEA:67623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:64386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine => H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine
REACT:R-DDI-141186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
RHEA:32253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)
REACT:R-HSA-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Homo sapiens)
REACT:R-HSA-389961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)
REACT:R-SPO-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Schizosaccharomyces pombe)
RHEA:43973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)
REACT:R-BTA-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Bos taurus)
REACT:R-CEL-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Caenorhabditis elegans)
GO:0018459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carveol dehydrogenase activity
GO:0018459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-trans-carveol:NADP+ oxidoreductase activity
GO:0018459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-trans-carveol dehydrogenase activity
RHEA:59250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA
REACT:R-SPO-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Schizosaccharomyces pombe)
REACT:R-HSA-2466391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)
REACT:R-PFA-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Plasmodium falciparum)
RHEA:22144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate + H2O = D-threo-isocitrate
RHEA:67074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acid + CoA + H(+) => a very long-chain fatty acyl-CoA + H2O
RHEA:22676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H(+) + NADPH + O2 = 7(1)-hydroxychlorophyllide a + H2O + NADP(+)
RHEA:33814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine <=> 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O
GO:0030761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 8-methyltransferase activity
GO:0030761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	8-hydroxyquercetin 8-O-methyltransferase activity
GO:0030761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxyquercitin 8-O-methyltransferase activity
GO:0030761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity
GO:0030761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 8-O-methyltransferase activity
REACT:R-GGA-158750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Gallus gallus)
RHEA:10298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH => D-glyceraldehyde 3-phosphate + NADP(+) + phosphate
REACT:R-SSC-2872498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Sus scrofa)
RHEA:62606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2
RHEA:10982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine => L-serine
EC:2.7.10.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Protein-tyrosine kinases"
EC:2.7.10.-	skos:prefLabel	"Protein-tyrosine kinases"
REACT:R-MMU-5663050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHI and DHICA polymerise forming eumelanin (Mus musculus)
RHEA:48286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NOR1 (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose
REACT:R-DRE-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Danio rerio)
REACT:R-DME-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Drosophila melanogaster)
REACT:R-DRE-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Danio rerio)
REACT:R-RNO-9614564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO4 (Rattus norvegicus)
RHEA:66026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen]
REACT:R-XTR-176700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Xenopus tropicalis)
RHEA:40109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA
REACT:R-BTA-165758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and inactivation of eEF2K by activated S6K1 (Bos taurus)
REACT:R-CFA-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Canis familiaris)
RHEA:69947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:34313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite => 4-nitrocatechol + NADH + O2
REACT:R-BTA-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Bos taurus)
REACT:R-MMU-9625487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates downstream of EGFR (Mus musculus)
REACT:R-MMU-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Mus musculus)
REACT:R-HSA-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Homo sapiens)
REACT:R-SSC-9697750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8:FLIP(L) (Sus scrofa)
RHEA:46967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate
REACT:R-DRE-6795667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the cytosol (Danio rerio)
REACT:R-DME-5683888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMCD1 binds GATA6, sequestering it (Drosophila melanogaster)
RHEA:51165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
RHEA:40086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Rattus norvegicus)
RHEA:61360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + pheophorbide a(in) = ADP + H(+) + pheophorbide a(out) + phosphate
GO:0102612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syn-pimaradiene 6beta-hydroxylase activity
RHEA:37647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:58443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine
RHEA:12312	skos:prefLabel	"dibenzothiophene sulfone monooxygenase"
RHEA:12312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dibenzothiophene sulfone monooxygenase"
RHEA:12312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)
EC:3.4.21.2	skos:altLabel	"caldecrin"
EC:3.4.21.2	skos:prefLabel	"chymotrypsin C"
EC:3.4.21.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chymotrypsin C"
REACT:R-HSA-9728723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Homo sapiens)
REACT:R-SSC-3785684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by CTSG (Sus scrofa)
RHEA:33276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)
REACT:R-CFA-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Canis familiaris)
RHEA:23622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + deoxyamidinoproclavaminate + diphosphate + H(+) => ATP + N(2)-(2-carboxyethyl)-L-arginine
REACT:R-HSA-2730851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
REACT:R-DRE-8852580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clusterin binds C5b-C7, C8, C9 (Danio rerio)
REACT:R-XTR-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Xenopus tropicalis)
RHEA:66689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O
RHEA:68259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine(in) + Na(+)(in) <=> L-cystine(out) + Na(+)(out)
RHEA:28219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + H(+) + H2O2 => H2O + hypochlorous acid
REACT:R-SSC-8848873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARAP1 (Sus scrofa)
RHEA:35755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-alpha-D-glucose = H(+) + NADH + UDP-3-oxo-alpha-D-glucose
GO:0009674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	high affinity potassium transporter
GO:0009674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium:sodium symporter activity
REACT:R-BTA-9021170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen stimulates dimerization of plasma membrane estrogen receptors (Bos taurus)
REACT:R-MMU-1433514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
REACT:R-CFA-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Canis familiaris)
RHEA:45071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + an acyl-CoA <=> CoA + O-acyl-(R)-carnitine
RHEA:41111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate
RHEA:52342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase] => a long-chain fatty acyl-AMP + holo-[mycocerosate synthase]
REACT:R-GGA-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)
REACT:R-XTR-2424485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-PLCG1 (Xenopus tropicalis)
RHEA:53360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(47) in tRNA + NADP(+) = H(+) + NADPH + uridine(47) in tRNA
REACT:R-DME-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Drosophila melanogaster)
REACT:R-RNO-6784189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind LIFR (Rattus norvegicus)
RHEA:50786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenal + H(+) + NADPH => dodecanal + NADP(+)
RHEA:24179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0102091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-5-phosphate phosphatase activity
GO:0102091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-5-phosphate 5-phosphatase activity
REACT:R-XTR-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Xenopus tropicalis)
RHEA:25328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + phosphocholine + S-adenosyl-L-homocysteine
RHEA:55070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:37869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA
RHEA:32310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> H2O + leukotriene A4
RHEA:11306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + urea => (S)-ureidoglycolate
RHEA:45172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-SPO-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Schizosaccharomyces pombe)
REACT:R-HSA-1237140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydration of methylthio-ribulose-P (Homo sapiens)
RHEA:28846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline(in) + H(+)(in) <=> choline(out) + H(+)(out)
REACT:R-CEL-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Caenorhabditis elegans)
REACT:R-DRE-8849900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs1-3 bind each other in cis interactions (Danio rerio)
RHEA:37319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-methionine(out) + H2O = ADP + glycyl-L-methionine(in) + H(+) + phosphate
REACT:R-GGA-8876837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB21 GEFs exchange GTP for GDP on RAB21 (Gallus gallus)
RHEA:12367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) <=> a quinol + beta-nicotinamide D-riboside
RHEA:69700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O => beta-D-glucose + N-hexadecanoylsphing-4-enine
REACT:R-RNO-176298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of claspin (Rattus norvegicus)
REACT:R-SPO-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Schizosaccharomyces pombe)
RHEA:42509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-acetamido-2-oxohexanoate + H2O + NAD(+) => 5-acetamidopentanoate + CO2 + H(+) + NADH
REACT:R-HSA-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)
RHEA:50914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol
GO:0106290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-cinnamate-CoA ligase activity
GO:0106290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate
REACT:R-RNO-873951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1:HSP90 binds inactive NLRP3 (Rattus norvegicus)
REACT:R-XTR-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Xenopus tropicalis)
REACT:R-MMU-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Mus musculus)
RHEA:69869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine => a uridine in RNA + S-adenosyl-L-methionine
REACT:R-SSC-5651654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)
RHEA:67778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O
REACT:R-DRE-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Danio rerio)
REACT:R-XTR-202717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of CEACAMs (Xenopus tropicalis)
REACT:R-DRE-9686920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 ubiquitinates RIPK3 at K363 (Danio rerio)
RHEA:69160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O + O2 = H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)
REACT:R-DRE-4085347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO1 (Danio rerio)
RHEA:70625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine
RHEA:41120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine
RHEA:19813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-asparagine = 2-oxosuccinamate + an L-alpha-amino acid
RHEA:46895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate
RHEA:54267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate
REACT:R-HSA-449087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD4 binds Interleukin-16 (Homo sapiens)
RHEA:50147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (9Z)-hexadecenoate + H2O <=> (9Z)-hexadecenoate + ethanol + H(+)
RHEA:59018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + cycloeucalenone + NADH => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+)
GO:0102296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity
REACT:R-MMU-391153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds GRB2-1 (Mus musculus)
GO:0043856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anti-anti-sigma factor activity
GO:0043856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anti-sigma factor antagonist activity
GO:0004820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycyl translase activity
GO:0004820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine-tRNA ligase activity
GO:0004820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-tRNA synthetase activity
GO:0004820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine:tRNAGly ligase (AMP-forming) activity
GO:0004820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycyl-transfer RNA synthetase activity
GO:0004820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycyl-transfer ribonucleic acid synthetase activity
GO:0004820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycyl-transfer ribonucleate synthetase activity
REACT:R-DRE-8950340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Danio rerio)
REACT:R-MMU-6789072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP1 binds bacterial peptidoglycan (Mus musculus)
RHEA:34416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-bornane-2,5-dione + FMNH2 + O2 => (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O
RHEA:11728	skos:prefLabel	"cyclopentanol dehydrogenase"
RHEA:11728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclopentanol dehydrogenase"
RHEA:11728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH
REACT:R-SSC-74742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 (Sus scrofa)
REACT:R-SSC-2161620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by PTGDS (Sus scrofa)
RHEA:40339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:35356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisopentadecanoyl-CoA => (2E)-13-methyltetradecenoyl-CoA + H2O
REACT:R-SSC-8932276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Sus scrofa)
RHEA:40293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + tetradecanedioyl-CoA => ATP + CoA + tetradecanedioate
GO:0043472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgD binding
REACT:R-DDI-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Dictyostelium discoideum)
RHEA:72664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine
REACT:R-GGA-909719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STAT2 to p-IFNAR1 (Gallus gallus)
RHEA:49109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine
RHEA:57054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-erythrulose => 3-oxoisoapionate + H(+)
RHEA:56306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-phosphorifampicin + AMP + 2 H(+) + phosphate => ATP + H2O + rifampicin
REACT:R-HSA-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Homo sapiens)
RHEA:56839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[PQQ precursor protein] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine
REACT:R-RNO-5624952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the retrograde IFT train (Rattus norvegicus)
REACT:R-CEL-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Caenorhabditis elegans)
REACT:R-BTA-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Bos taurus)
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-cyclodextrin glucanotransferase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-cyclodextrin glycosyltransferase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclomaltodextrin glucotransferase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CGTase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclodextrin glucanotransferase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neutral-cyclodextrin glycosyltransferase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,4-glucan 4-glycosyltransferase, cyclizing
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	konchizaimu
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyclodextrin glucanotransferase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BMA
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-cyclodextrin glycosyltransferase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclomaltodextrin glycosyltransferase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclomaltodextrin glucanotransferase activity
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Bacillus macerans amylase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyclodextrin glycosyltransferase
GO:0043895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclodextrin glycosyltransferase
RHEA:69495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octan-1-ol <=> H2O2 + octanal
REACT:R-SSC-2213236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Sus scrofa)
RHEA:34615	skos:prefLabel	"methylphosphonate synthase"
RHEA:34615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylphosphonate synthase"
RHEA:34615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + O2 = H(+) + hydrogencarbonate + methylphosphonate
REACT:R-HSA-8938440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-17 binds RUNX1 mRNA (Homo sapiens)
RHEA:42008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH
REACT:R-MMU-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Mus musculus)
RHEA:54970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + phosphate => hexadecanoyl phosphate + sn-glycerol 3-phosphate
REACT:R-XTR-1482679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2G2A (Xenopus tropicalis)
RHEA:46712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine
RHEA:61741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolmonoside + UDP-alpha-D-glucose => H(+) + steviolbioside + UDP
REACT:R-XTR-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Xenopus tropicalis)
GO:0018721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity
GO:0018721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity
RHEA:45511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]
GO:0050214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	progesterone monooxygenase activity
GO:0050214	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	progesterone hydroxylase activity
GO:0050214	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
REACT:R-BTA-8948226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Bos taurus)
REACT:R-CFA-9796691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPATA2 links CYLD to LUBAC (Canis familiaris)
REACT:R-CFA-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Canis familiaris)
REACT:R-SSC-1295540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Sus scrofa)
REACT:R-MMU-9026405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Mus musculus)
REACT:R-GGA-8868230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
REACT:R-BTA-2530429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of soluble VTN:C5b-C9  (Bos taurus)
RHEA:45183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (E)-4-coumaroyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine
REACT:R-XTR-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Xenopus tropicalis)
REACT:R-GGA-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Gallus gallus)
RHEA:42873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine
RHEA:14518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H2O => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA
REACT:R-SSC-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Sus scrofa)
RHEA:64679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoyl-CoA + butan-1-ol <=> butyl 3-(methylsulfanyl)propanoate + CoA
REACT:R-HSA-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Homo sapiens)
REACT:R-MMU-5683384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UIMC1 and FAM175A bind DNA DSBs (Mus musculus)
REACT:R-GGA-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Gallus gallus)
REACT:R-RNO-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Rattus norvegicus)
RHEA:45397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:52488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1358795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitination of RNF41 by P-USP8 (Homo sapiens)
RHEA:66401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycocholate(in) + H2O => ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate
REACT:R-DRE-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Danio rerio)
RHEA:41215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)
REACT:R-DDI-1678716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(1) (Dictyostelium discoideum)
REACT:R-DRE-163099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alignment Of The RNA Template On The Telomeric Chromosome End (Danio rerio)
RHEA:33483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + ergosterol = CoA + ergosteryl ester
REACT:R-HSA-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Homo sapiens)
REACT:R-XTR-2990842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO2 (Xenopus tropicalis)
RHEA:11374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-asparagine => ATP + L-aspartate + NH4(+)
RHEA:36129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-methyl gibberellin A34 + S-adenosyl-L-homocysteine => gibberellin A34 + S-adenosyl-L-methionine
RHEA:38029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate => (E)-caffeate + hydrocaffeoyl-CoA
RHEA:43079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-870479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) binds to ubiquitinated SMAD4 (Homo sapiens)
REACT:R-DDI-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Dictyostelium discoideum)
RHEA:43593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral
REACT:R-MMU-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Mus musculus)
REACT:R-PFA-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Plasmodium falciparum)
REACT:R-CFA-2029459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Canis familiaris)
RHEA:51064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate
REACT:R-DME-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Drosophila melanogaster)
REACT:R-MMU-4551683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOPORS with SUMO1 (Mus musculus)
REACT:R-CFA-453104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
REACT:R-MMU-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Mus musculus)
GO:0003688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA replication origin binding
GO:0003688	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ARS binding
REACT:R-RNO-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Rattus norvegicus)
REACT:R-BTA-6784628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)
RHEA:35688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetradecasphinganine => 3-oxotetradecasphinganine + H(+) + NADPH
REACT:R-MMU-1678981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR9 processing at neutral pH (Mus musculus)
RHEA:71941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + 3 Na(+)(in) => 2-oxoglutarate(out) + 3 Na(+)(out)
RHEA:68807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kojibiose <=> alpha-D-glucose + D-glucose
REACT:R-DRE-354087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2 to p-PTK2 (Danio rerio)
REACT:R-BTA-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Bos taurus)
RHEA:20318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NADP(+) => 1-pyrroline-2-carboxylate + H(+) + NADPH
REACT:R-DME-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Drosophila melanogaster)
REACT:R-DME-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Drosophila melanogaster)
REACT:R-BTA-6814683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Bos taurus)
REACT:R-SSC-8850945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates PTEN (Sus scrofa)
RHEA:11864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trimethylamine dehydrogenase"
RHEA:11864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine = dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]
RHEA:11864	skos:altLabel	"TMADh"
RHEA:11864	skos:prefLabel	"trimethylamine dehydrogenase"
REACT:R-BTA-391905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxoeicosanoid receptor can bind oxoeicosanoid (Bos taurus)
RHEA:12140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)
RHEA:54736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF receptor activity
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vascular endothelial growth factor receptor activity
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vascular endothelial growth factor-activated receptor activity
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	VEGF-C-activated receptor activity
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR activity
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	VEGF-E-activated receptor activity
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	VEGF-B-activated receptor activity
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	VEGF-D-activated receptor activity
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	VEGF-A-activated receptor activity
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-activated receptor activity
GO:0005021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vascular endothelial growth factor E-activated receptor activity
REACT:R-DRE-2022887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 N-deacetylates GlcNAc residues in heparan (Danio rerio)
REACT:R-HSA-9034875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 phosphorylates SHC1 (Homo sapiens)
RHEA:38734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol
REACT:R-HSA-9712187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAL:GTP (G alpha-olf) binds ADCY3 (Homo sapiens)
REACT:R-HSA-9698013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11:p-STAT5 dissociates from mutant FLT3 (Homo sapiens)
RHEA:15346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginine + L-tyrosine => AMP + diphosphate + H(+) + L-tyrosyl-L-arginine
GO:0033887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondro-4-sulfatase activity
GO:0033887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity
REACT:R-SSC-5684801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y7-CLEC1B dimer:PDPN binds SYK (Sus scrofa)
GO:0016869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular transferase activity, transferring amino groups
GO:0016869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring amino groups"
GO:0016869	skos:prefLabel	"Transferring amino groups"
RHEA:15211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3R)-tartrate + NAD(+)
REACT:R-RNO-3788725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C complex binds EHMT1:EHMT2 (Rattus norvegicus)
REACT:R-HSA-8964531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)
REACT:R-GGA-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Gallus gallus)
REACT:R-SSC-3149519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC decyanates CNCbl (Sus scrofa)
RHEA:39688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-(11Z)-octadecenoyl-CoA => (2E,11Z)-octadecadienoyl-CoA + H2O
REACT:R-MMU-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Mus musculus)
RHEA:65039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-BTA-6785986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases unhook the interstrand crosslink (ICL) (Bos taurus)
RHEA:17710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-nonaprenyl diphosphate => 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate
RHEA:63763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine
REACT:R-CEL-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Caenorhabditis elegans)
REACT:R-CEL-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)
RHEA:53805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholoyl-CoA + ursodeoxycholate => allodeoxycholate + ursodeoxycholoyl-CoA
RHEA:70375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + dodecanoyl-CoA = CoA + H(+) + N-dodecanoyl-3-oxosphinganine
RHEA:60158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-galactose(in) + H(+) + phosphate => ATP + D-galactose(out) + H2O
GO:0102761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eriodictyol 3'-O-methyltransferase activity
RHEA:46924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O
RHEA:46924	skos:altLabel	"2-hydroxyisocaproyl-CoA dehydratase"
RHEA:46924	skos:prefLabel	"(R)-2-hydroxyisocaproyl-CoA dehydratase"
RHEA:46924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-2-hydroxyisocaproyl-CoA dehydratase"
REACT:R-RNO-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Rattus norvegicus)
RHEA:32854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
GO:0018699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1,1-trichloroethane reductive dehalogenase activity
RHEA:56889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-4-dehydro-beta-L-rhamnose
REACT:R-DRE-2559639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV sulfilimine cross-linking by peroxidasin (Danio rerio)
GO:0018724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phenanthrol sulphotransferase activity
GO:0018724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phenanthrol sulfotransferase activity
REACT:R-DRE-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Danio rerio)
REACT:R-MMU-5323526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRAT proteins bind GSK3beta (Mus musculus)
REACT:R-XTR-174445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap on the C-strand (Xenopus tropicalis)
REACT:R-BTA-2530501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTA:FNTB transfers FARN to GNGT1 (Bos taurus)
REACT:R-HSA-9635996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 resolves psoralen-induced ICLs (Homo sapiens)
RHEA:38293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + CoA + H(+) => (S)-malyl-CoA + H2O
REACT:R-DME-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Drosophila melanogaster)
RHEA:30758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamate <=> ADP + carbamoyl phosphate
REACT:R-HSA-398193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
REACT:R-BTA-109291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Bos taurus)
REACT:R-BTA-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Bos taurus)
REACT:R-SSC-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Sus scrofa)
REACT:R-SSC-174235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdc20 (Sus scrofa)
GO:0004461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactose synthetase activity
GO:0004461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:D-glucose 4-beta-D-galactotransferase activity
GO:0004461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-glucose galactosyltransferase activity
GO:0004461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:D-glucose 4-beta-D-galactotransferase activity
GO:0004461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose-glucose galactosyltransferase activity
GO:0004461	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-glucose galactosyltransferase activity
GO:0004461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose synthase activity
REACT:R-CFA-5696365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)
RHEA:45742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyectoine + CO2 + succinate => 2-oxoglutarate + L-ectoine + O2
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-L-glycerol-3-phosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-glycerol phosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate dehydrogenase (NAD(P)+) activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glycerophosphate dehydrogenase (NAD) activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent glycerol phosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycerol-3-phosphate dehydrogenase [NADP+] activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol 1-phosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-alpha-glycerol phosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked glycerol 3-phosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-glycerophosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dihydroxyacetone phosphate reductase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol-3-phosphate dehydrogenase (NAD) activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-alpha-glycerophosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glycerol phosphate dehydrogenase (NAD) activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol phosphate dehydrogenase (NAD) activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphate dehydrogenase (NAD) activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroglycerophosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent glycerol-3-phosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-alpha-glycerophosphate dehydrogenase activity
GO:0047952	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glycerol-3-phosphate:NAD(P) oxidoreductase activity
REACT:R-BTA-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Bos taurus)
REACT:R-DRE-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Danio rerio)
REACT:R-MMU-1679098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Mus musculus)
RHEA:33111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-copaene synthase"
RHEA:33111	skos:altLabel	"Cop4"
RHEA:33111	skos:prefLabel	"beta-copaene synthase"
RHEA:33111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate
REACT:R-HSA-5655142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 binds POLH (Homo sapiens)
REACT:R-DRE-4755494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Danio rerio)
RHEA:23754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + all-trans-undecaprenyl phosphate + H(+) => all-trans-undecaprenol + ATP
RHEA:29424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + diphosphate => ADP + H(+) + triphosphate
REACT:R-SCE-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Saccharomyces cerevisiae)
REACT:R-SSC-8866553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded CFTR is degraded by the 26S proteasome (Sus scrofa)
REACT:R-HSA-167566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nef mediated disruption of CD4:Lck Complex (Homo sapiens)
REACT:R-HSA-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Homo sapiens)
REACT:R-GGA-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Gallus gallus)
REACT:R-BTA-4088264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Bos taurus)
REACT:R-XTR-2161950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Xenopus tropicalis)
GO:0038025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reeler receptor activity
GO:0038025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reelin receptor activity
REACT:R-DRE-8853429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLDA1 binds AURKA (Danio rerio)
RHEA:16858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Dictyostelium discoideum)
REACT:R-MMU-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Mus musculus)
RHEA:36789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-MMU-741386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 induces K63-linked ubiquitination of NEMO (Mus musculus)
REACT:R-DME-163741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Drosophila melanogaster)
REACT:R-CEL-5205663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)
REACT:R-MMU-1461982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-defensin dimers multimerize to form a pore complex (Mus musculus)
RHEA:47965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate
RHEA:38089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol
RHEA:44986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-3-methylbutanoyl-(R)-carnitine => (R)-carnitine + 3-methylbutanoyl-CoA
REACT:R-HSA-9659380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
REACT:R-BTA-9645406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Bos taurus)
RHEA:42573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2
RHEA:56473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
RHEA:17274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) => 4-hydroxyphenylacetate + 2 H(+) + NADH
REACT:R-HSA-9022728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 gene expression is inhibited by MECP2 (Homo sapiens)
REACT:R-DME-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Drosophila melanogaster)
REACT:R-DRE-1483159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho is dephosphorylated to Cho by PHOSPHO1 (Danio rerio)
RHEA:24967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]
RHEA:41493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine
RHEA:17482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH
REACT:R-HSA-9662114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
REACT:R-BTA-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Bos taurus)
REACT:R-DRE-187828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p21 to the nucleus (Danio rerio)
REACT:R-HSA-9698930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCMV C Nucleocapsid Translocation (Homo sapiens)
REACT:R-MMU-6781905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZRANB1 binds APC (Mus musculus)
REACT:R-MMU-1112510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6ST is tyrosine phosphorylated (Mus musculus)
RHEA:50316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl octadecanoate + H2O = ethanol + H(+) + octadecanoate
REACT:R-HSA-9010646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP5 recruits PKC to ROBO3.1 (Homo sapiens)
REACT:R-DDI-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Dictyostelium discoideum)
RHEA:40178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octanoyl-CoA <=> (2E)-octenoyl-CoA + H2O2
RHEA:22303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucoside + H(+) + UDP
REACT:R-DRE-9027607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Danio rerio)
GO:0103059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + UDP-beta-L-rhamnose = H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP
GO:0103059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity
REACT:R-HSA-8937656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 negatively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)
RHEA:60434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cannabichromenate => A + cannabigerolate
RHEA:17094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol
RHEA:41817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GD2 (d18:1(4E)) + H(+) + UDP
REACT:R-XTR-5638012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D dissociates from ARL13B:INPP5E (Xenopus tropicalis)
RHEA:70552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose => 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP
REACT:R-CEL-1475032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Caenorhabditis elegans)
RHEA:39770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0004566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronidase activity
GO:0004566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-D-glucuronidase activity
GO:0004566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-glucuronoside glucuronosohydrolase activity
GO:0004566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glucuronide glucuronohydrolase activity
GO:0004566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketodase activity
GO:0004566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucuronidase activity
REACT:R-HSA-9660819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2B:Ade-Rib:GsGTP dissociates (Homo sapiens)
REACT:R-MMU-375151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with collagens (Mus musculus)
REACT:R-MMU-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Mus musculus)
RHEA:43907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol <=> all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine
GO:0000175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5' exoribonuclease activity
GO:0000175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Homo sapiens)
GO:0000175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5'-exoribonuclease activity
RHEA:30393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamine
REACT:R-CFA-5362486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Canis familiaris)
GO:0050897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt binding
GO:0050897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co ion binding
GO:0050897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt ion binding
REACT:R-MMU-1112666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)
REACT:R-RNO-9029150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Rattus norvegicus)
REACT:R-GGA-2396594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Gallus gallus)
RHEA:42944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(40) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
RHEA:25510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S)-sabinene + diphosphate => (2E)-geranyl diphosphate
RHEA:67469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine
REACT:R-XTR-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Xenopus tropicalis)
REACT:R-BTA-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Bos taurus)
REACT:R-SCE-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Saccharomyces cerevisiae)
REACT:R-DRE-9038029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxysterol binds ESR1, ESR2 (Danio rerio)
RHEA:19472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 nitric oxide + 2 O2 <=> H(+) + NAD(+) + 2 nitrate
RHEA:40486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)
REACT:R-CFA-76500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBXAS1 isomerises PGH2 to TXA2 (Canis familiaris)
RHEA:23834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an N-acyl-D-mannosamine 6-phosphate + H(+) => an N-acyl-D-mannosamine + ATP
RHEA:72011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(in) + urate(out) = glutathione(out) + urate(in)
GO:0004737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate decarboxylase activity
GO:0004737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-acid carboxy-lyase (aldehyde-forming)
GO:0004737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic decarboxylase activity
GO:0004737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-acid carboxy-lyase activity
GO:0004737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-carboxylase activity
GO:0004737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoacid carboxylase activity
RHEA:34846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromonapterin 3'-triphosphate + 3 H2O <=> 7,8-dihydromonapterin + 2 H(+) + 3 phosphate
REACT:R-SSC-6800490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates PIDD1 (Sus scrofa)
REACT:R-MMU-1482571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)
RHEA:16527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+) => 2-dehydro-3-deoxy-D-galactonate + ATP
REACT:R-SPO-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Schizosaccharomyces pombe)
GO:0102993	skos:prefLabel	"sn-2 acyl-lipid omega-3 desaturase (ferredoxin)"
GO:0102993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0102993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linolenate delta15 desaturase activity
GO:0102993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sn-2 acyl-lipid omega-3 desaturase (ferredoxin)"
GO:0102993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Mus musculus)
REACT:R-RNO-5668414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Rattus norvegicus)
RHEA:60173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA
REACT:R-BTA-9025152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Bos taurus)
REACT:R-DRE-5683384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UIMC1 and FAM175A bind DNA DSBs (Danio rerio)
RHEA:33992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => alpha-copaene + diphosphate
REACT:R-CFA-9725206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds FCERI (Canis familiaris)
REACT:R-HSA-9013568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HES5 gene expression is stimulated by NOTCH3 (Homo sapiens)
REACT:R-SCE-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)
RHEA:21998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA => a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA
RHEA:38832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine
RHEA:43373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + dTDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)
REACT:R-HSA-9031896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PD1n-3, PD2n-3 translocate from cytosol to extracellular region (Homo sapiens)
RHEA:17875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an R-cob(III)alamin(in) + H(+) + phosphate => an R-cob(III)alamin(out) + ATP + H2O
REACT:R-GGA-1564142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV degradation by MMP2,3,4,9,10,12 (Gallus gallus)
REACT:R-SSC-8848355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes retinyl palmitate (Sus scrofa)
REACT:R-CFA-181450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Canis familiaris)
REACT:R-XTR-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Xenopus tropicalis)
RHEA:17752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinoline <=> AH2 + quinolin-2(1H)-one
REACT:R-DRE-3928656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves EPHB2 (Danio rerio)
REACT:R-BTA-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Bos taurus)
REACT:R-MMU-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Mus musculus)
REACT:R-SSC-9706312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to LCK (Sus scrofa)
RHEA:64451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine
RHEA:47180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) = (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH
RHEA:22120	skos:prefLabel	"succinate--CoA ligase (GDP-forming)"
RHEA:22120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + GTP + succinate = GDP + phosphate + succinyl-CoA
RHEA:22120	skos:altLabel	"succinyl-CoA synthetase (GDP-forming)"
RHEA:22120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinate--CoA ligase (GDP-forming)"
REACT:R-HSA-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Homo sapiens)
RHEA:36588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldopyranose + NADP(+) => aldono-1,5-lactone + H(+) + NADPH
REACT:R-MMU-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Mus musculus)
REACT:R-MMU-1433428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2 is indirectly recruited to p-KIT through SHP2 (Mus musculus)
REACT:R-DRE-6810357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fillagrin and keratin intermediate filaments polymerise forming a network (Danio rerio)
RHEA:25342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + urea = carbamate + NH4(+)
RHEA:16720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + FAD + H(+) + H2O <=> cholate + FADH2
REACT:R-DRE-9027275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Danio rerio)
GO:0032395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T cell receptor activity
GO:0032395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-beta T cell receptor activity
GO:0032395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-delta T cell receptor activity
GO:0032395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II receptor activity
RHEA:13954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-aminoacyl-tRNA + H2O => a D-alpha-amino acid + a tRNA + H(+)
RHEA:19299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + carnosine + H(+) + phosphate => ATP + beta-alanine + L-histidine
RHEA:57378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]
EC:3.4.24.50	skos:prefLabel	"bothrolysin"
EC:3.4.24.50	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bothrolysin"
EC:3.4.24.50	skos:altLabel	"J protease"
EC:3.4.24.50	skos:altLabel	"Bothrops metalloendopeptidase J"
RHEA:49578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + GTP + S-adenosyl-L-methionine
REACT:R-HSA-9694601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3-4 cleaves itself (Homo sapiens)
GO:0047103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THAL-NAD oxidoreductase activity
GO:0047103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity
GO:0047103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity
GO:0047103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity
GO:0047103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity
GO:0047103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trihydroxydeoxycoprostanal dehydrogenase activity
GO:0047103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity
GO:0047103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity
GO:0047103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholestanetriol-26-al 26-dehydrogenase activity
GO:0047103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]
REACT:R-GGA-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Gallus gallus)
REACT:R-GGA-114259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase‑9 to caspase‑9 (Gallus gallus)
REACT:R-BTA-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Bos taurus)
REACT:R-BTA-8955289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
GO:0052796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-alpha-2,8-sialidase activity
GO:0052796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-alpha-(2,8)-sialidase activity
GO:0052796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-alpha-(2->8)-sialidase activity
REACT:R-HSA-210274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP beta binds TYROBP (Homo sapiens)
REACT:R-HSA-174174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Homo sapiens)
GO:0016653	skos:prefLabel	"With a heme protein as acceptor"
GO:0016653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a heme protein as acceptor"
GO:0016653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
GO:0016653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
GO:0016653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor
REACT:R-HSA-8948641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-106 microRNAs bind VAPA mRNA (Homo sapiens)
REACT:R-SCE-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Saccharomyces cerevisiae)
REACT:R-HSA-1564179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens)
REACT:R-CFA-5683384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UIMC1 and FAM175A bind DNA DSBs (Canis familiaris)
RHEA:64457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine
REACT:R-BTA-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Bos taurus)
RHEA:23862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cephalosporin C + CoA => acetyl-CoA + deacetylcephalosporin C
REACT:R-SCE-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Saccharomyces cerevisiae)
REACT:R-CEL-2213240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of disulphide bonds in MHC II antigens (Caenorhabditis elegans)
REACT:R-MMU-5654608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS bind to PPTN11 (Mus musculus)
RHEA:72777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + ochratoxin B + phosphate => 7-carboxymellein + ATP + L-phenylalanine
REACT:R-DDI-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Dictyostelium discoideum)
RHEA:38096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocotrienol + S-adenosyl-L-methionine => alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-1504186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL recruits GSK3beta:AXIN1 to the receptor complex (Xenopus tropicalis)
RHEA:37582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:67425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid + H2O => a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)
RHEA:18662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) => H(+) + L-ornithine + NADPH + pyruvate
GO:0015210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil transmembrane transporter activity
GO:0015210	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uracil/uridine permease activity
REACT:R-CEL-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Caenorhabditis elegans)
GO:0015537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthosine:proton symporter activity
GO:0015537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthosine:hydrogen ion symporter activity
GO:0015537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthosine permease activity
REACT:R-HSA-5671772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T38-PPP1R14A binds MLCP (Homo sapiens)
REACT:R-CFA-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Canis familiaris)
RHEA:55609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base
RHEA:23447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + NAD(+) <=> H(+) + NADH + pyruvate
REACT:R-HSA-6814298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
REACT:R-HSA-445699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Homo sapiens)
REACT:R-MMU-5218822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK binds BCAR1 and or PXN (Mus musculus)
RHEA:14940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-8851919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 and GRB2 (Rattus norvegicus)
REACT:R-BTA-374214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CXCR4 and 7 bind CXCL12 ligand (Bos taurus)
RHEA:10598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]
RHEA:21691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a polyvinyl alcohol + n O2 <=> an oxidized polyvinyl alcohol + n H2O2
REACT:R-HSA-159795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Homo sapiens)
REACT:R-HSA-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
RHEA:52894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + nitrobenzene => H2O + NADP(+) + nitrosobenzene
REACT:R-DDI-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Dictyostelium discoideum)
RHEA:72203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(out) + hydrogencarbonate(in) = 2 chloride(in) + hydrogencarbonate(out)
REACT:R-SCE-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Saccharomyces cerevisiae)
REACT:R-DRE-432195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Danio rerio)
REACT:R-DDI-4167509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial BTD hydrolyses BCTN (Dictyostelium discoideum)
REACT:R-SSC-210274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP beta binds TYROBP (Sus scrofa)
RHEA:50842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2
REACT:R-HSA-9690449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 bind S1P (Homo sapiens)
REACT:R-XTR-5252079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Xenopus tropicalis)
RHEA:34758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine <=> D-glucose + N-acyl-15-methylhexadecasphing-4-enine
RHEA:26170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + H(+) + pyruvate => 3-fumarylpyruvate + H2O
REACT:R-DME-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Drosophila melanogaster)
REACT:R-XTR-8849463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates SFPQ (Xenopus tropicalis)
REACT:R-HSA-351323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 78 kDa glucose-regulated protein (Homo sapiens)
RHEA:45386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:20777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose => myo-inositol + stachyose
REACT:R-HSA-5334794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABPs bind LCFAs (Homo sapiens)
REACT:R-DME-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)
GO:0019113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene monooxygenase activity
GO:0050416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formiminoglutamate deiminase activity
GO:0050416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-formimidoyl-L-glutamate iminohydrolase activity
GO:0050416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formiminoglutamic iminohydrolase activity
GO:0050416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formimidoylglutamate deiminase activity
REACT:R-SCE-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Saccharomyces cerevisiae)
RHEA:27303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloro-L-tryptophan + O2 => 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2
REACT:R-HSA-2559568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)
REACT:R-HSA-416530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1:FFAR1 ligands activates Gq (Homo sapiens)
REACT:R-MMU-8950342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBI3:CANX binds IL27 (Mus musculus)
REACT:R-BTA-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Bos taurus)
REACT:R-BTA-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)
GO:0009012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside 3''-adenylyltransferase activity
GO:0009012	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AAD (3'')
GO:0009012	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP:streptomycin 3''-adenylyltransferase activity
GO:0009012	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptomycin 3''-adenylyltransferase activity
REACT:R-SSC-192065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)
REACT:R-DRE-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Danio rerio)
REACT:R-MMU-5693609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53 at S15 (Mus musculus)
RHEA:22258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxoacyl-CoA + H(+) + NADPH => a (3R)-3-hydroxyacyl-CoA + NADP(+)
RHEA:53950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate => ATP + holo-[BtrI ACP] + L-glutamate
REACT:R-HSA-5659989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P (Homo sapiens)
REACT:R-MMU-193787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Mus musculus)
GO:0030275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRR domain binding
REACT:R-HSA-140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS1 (Homo sapiens)
REACT:R-SSC-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Sus scrofa)
REACT:R-DDI-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Dictyostelium discoideum)
RHEA:19789	skos:altLabel	"NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase"
RHEA:19789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(dimethylamino)azobenzene + H2O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH
RHEA:19789	skos:altLabel	"NADPH-dependent DMAB N-oxide reductase"
RHEA:19789	skos:altLabel	"dimethylaminoazobenzene N-oxide reductase"
RHEA:19789	skos:prefLabel	"4-(dimethylamino)phenylazoxybenzene reductase"
RHEA:19789	skos:altLabel	"N,N-dimethyl-p-aminoazobenzene oxide reductase"
RHEA:19789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-(dimethylamino)phenylazoxybenzene reductase"
REACT:R-CEL-9667965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds PP2A (Caenorhabditis elegans)
RHEA:15342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide => ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate
REACT:R-DRE-6784959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPHL hydrolyses VACV to ACV (Danio rerio)
RHEA:71594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + malonate(in) <=> 2-oxoglutarate(in) + malonate(out)
REACT:R-DME-1295609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates SPRY2 on Y55 and Y227 (Drosophila melanogaster)
REACT:R-MMU-873921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of STAT1 to p-IFNGR1 (Mus musculus)
REACT:R-DRE-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Danio rerio)
REACT:R-HSA-9793680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPTN binds polyUb-RIPK1 within the TNFR1 complex (Homo sapiens)
REACT:R-CFA-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Canis familiaris)
RHEA:11955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate <=> 2-hydroxy-3-oxopropanoate
RHEA:61433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH
REACT:R-GGA-9007901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RL2 (Gallus gallus)
RHEA:65301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chrodrimanin C + O2 => CO2 + H2O + succinate + verruculide A
RHEA:51546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose => D-ribulose
RHEA:51314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine
REACT:R-HSA-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Homo sapiens)
RHEA:44184	skos:prefLabel	"2-epi-5-epi-valiolone synthase"
RHEA:44184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-epi-5-epi-valiolone synthase"
RHEA:44184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate
RHEA:44184	skos:altLabel	"C7-cyclitol synthase"
RHEA:18951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol
RHEA:44648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)
REACT:R-HSA-9757688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDN (Homo sapiens)
REACT:R-SPO-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Schizosaccharomyces pombe)
REACT:R-CFA-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Canis familiaris)
RHEA:44085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + heptadecanoate => AMP + diphosphate + heptadecanoyl-CoA
RHEA:49090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + hydroxysqualene => FAD + H(+) + H2O + squalene
RHEA:19498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate => beta-alanine + CO2
REACT:R-XTR-174097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdh1 (Xenopus tropicalis)
REACT:R-XTR-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Xenopus tropicalis)
RHEA:13164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine + NAD(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADH
REACT:R-DDI-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Dictyostelium discoideum)
RHEA:43231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine
REACT:R-HSA-379382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates DA to DOPAC (Homo sapiens)
RHEA:69889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) + uridine(in) => Na(+)(out) + uridine(out)
REACT:R-RNO-3364026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SET1 complex trimethylates H3K4 at the MYC gene (Rattus norvegicus)
REACT:R-XTR-444527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR is a receptor for formyl peptides (Xenopus tropicalis)
REACT:R-BTA-5205649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 links damaged mitochondria to LC3 (Bos taurus)
REACT:R-HSA-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Homo sapiens)
REACT:R-CFA-8855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR binds DAB1 (Canis familiaris)
RHEA:22001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + NADP(+) => D-xylono-1,5-lactone + H(+) + NADPH
REACT:R-XTR-549129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations into hepatic cells (Xenopus tropicalis)
RHEA:51181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
GO:0102716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A28,oxoglutarate:oxygen oxidoreductase activity
REACT:R-RNO-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Rattus norvegicus)
REACT:R-HSA-2028670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Homo sapiens)
REACT:R-DME-450551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 binds translation and heat shock proteins (Drosophila melanogaster)
RHEA:37452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA => 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA
RHEA:25593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2
RHEA:25593	skos:prefLabel	"2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase"
RHEA:25593	skos:altLabel	"SEPHCHC synthase"
RHEA:25593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase"
RHEA:30693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + 2 H2O => H2O2 + methanol
REACT:R-SCE-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Saccharomyces cerevisiae)
REACT:R-BTA-6786095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates STAT3,STAT6 (Bos taurus)
REACT:R-BTA-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Bos taurus)
REACT:R-BTA-8854897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Bos taurus)
GO:0098601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenomethionine adenosyltransferase activity
REACT:R-BTA-204169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP dephosphorylates p-lipo-PDH (Bos taurus)
RHEA:17216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-mannosamine
REACT:R-HSA-6811504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)
RHEA:46720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O
GO:0103004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxystearate hydroxylase activity
REACT:R-DME-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Drosophila melanogaster)
REACT:R-SSC-9796387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Sus scrofa)
RHEA:36235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA
REACT:R-CFA-917814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Canis familiaris)
GO:0018734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyrolactone hydrolase activity
RHEA:37351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine 2'-phosphate + H2O = cytidine + phosphate
REACT:R-MMU-2984220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1:CCNB phosphorylates NEK9 (Mus musculus)
REACT:R-SSC-1977959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with EGFR (Sus scrofa)
RHEA:57425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guaiacol + O2 + reduced [NADH--hemoprotein reductase] => catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
REACT:R-XTR-8875540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 recruits CRK,CRKL to MET (Xenopus tropicalis)
RHEA:53896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)
REACT:R-CFA-1112708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-Y759-IL6ST (Canis familiaris)
GO:0030156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diazepam binding inhibitor activity
GO:0030156	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	benzodiazepine receptor ligand
GO:0030156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzodiazepine receptor binding
REACT:R-CEL-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)
REACT:R-RNO-5694082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XK:KEL:Zn2+ cleaves EDN3 (Rattus norvegicus)
REACT:R-RNO-193711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
REACT:R-MMU-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Mus musculus)
GO:0047992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylysine kinase activity
GO:0047992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylysine kinase (phosphorylating)
GO:0047992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP:5-hydroxy-L-lysine O-phosphotransferase activity
GO:0047992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity
GO:0015640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	muropeptide transporter activity
GO:0015640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	murein peptide transporter activity
GO:0015640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan peptide transmembrane transporter activity
RHEA:20661	skos:prefLabel	"D-Ala-D-Ala dipeptidase"
RHEA:20661	skos:altLabel	"D-alanyl-D-alanine dipeptidase"
RHEA:20661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanyl-D-alanine + H2O = 2 D-alanine
RHEA:20661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-Ala-D-Ala dipeptidase"
RHEA:54879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3S)-3-isopropenyl-6-oxoheptanoate + H(+)
RHEA:37990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocopherol <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol
RHEA:59690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaono-1,5-lactone + H2O2 => D-maltoheptaose + O2
GO:0015558	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-aminobenzoyl-glutamate transmembrane transporter activity
GO:0015558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-aminobenzoyl-glutamate uptake permease activity
GO:0015558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-aminobenzoyl-glutamate uptake transmembrane transporter activity
GO:0015558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-aminobenzoyl-glutamate transporter activity
GO:0015558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(4-aminobenzoyl)-L-glutamate(in) = N-(4-aminobenzoyl)-L-glutamate(out)
GO:0015558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RHEA:68827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (Z)-beta-ocimene + diphosphate
REACT:R-XTR-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Xenopus tropicalis)
RHEA:66193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + bilirubin-bisglucuronoside(in) + H2O => ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate
RHEA:59377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate => 4-amino-4-deoxyprephenate
REACT:R-MMU-6788628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dissociate (Mus musculus)
RHEA:58367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain primary fatty alcohol + NADP(+) <=> a medium-chain fatty aldehyde + H(+) + NADPH
REACT:R-CFA-9706390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds interacting proteins at trans-Golgi network (Canis familiaris)
REACT:R-RNO-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
RHEA:16168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 <=> CO2 + H2O + indole-3-acetamide
RHEA:19093	skos:prefLabel	"siroheme decarboxylase"
RHEA:19093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2
RHEA:19093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"siroheme decarboxylase"
REACT:R-CFA-1250383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Canis familiaris)
REACT:R-DRE-209910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is taken up by thyroid epithelial cells (Danio rerio)
REACT:R-DME-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Drosophila melanogaster)
REACT:R-DRE-5195402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LPIN (Danio rerio)
GO:0140750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleosome array spacing activity
GO:0140750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleosome array spacer activity
REACT:R-HSA-5682588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 binds phosphorylated MDC1 at DNA DSBs (Homo sapiens)
RHEA:45010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoate + sphinganine => H2O + N-(octadecanoyl)-sphinganine
REACT:R-CFA-5687360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLL or POLM extends aligned DNA DSB ends to fill gaps (Canis familiaris)
REACT:R-HSA-3341343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
REACT:R-HSA-5654582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates SHC1 (Homo sapiens)
RHEA:11116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an alkane-alpha,omega-diamine = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)
REACT:R-BTA-8987096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)
RHEA:49225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]
RHEA:38964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + leukotriene C4(in) => ADP + H(+) + leukotriene C4(out) + phosphate
RHEA:16571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[collagen] + O2
REACT:R-DDI-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Dictyostelium discoideum)
REACT:R-GGA-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Gallus gallus)
REACT:R-HSA-198563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO1 dioxygenates L-Trp to NFK (Homo sapiens)
REACT:R-SSC-202726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F11R dimerises (Sus scrofa)
REACT:R-BTA-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Bos taurus)
REACT:R-SSC-141341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMOX-3 oxidises SPN to SPM (Sus scrofa)
REACT:R-SSC-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Sus scrofa)
GO:0035375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zymogen binding
GO:0035375	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proenzyme binding
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SUMT activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SirA
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen-III methyltransferase activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uroporphyrin-III C-methyltransferase activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen methyltransferase activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylmethionine-uroporphyrinogen III methyltransferase activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urogen III methylase activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen III methylase activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen-III C-methyltransferase activity
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobA
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CysG
GO:0004851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen-III methylase activity
RHEA:13265	skos:altLabel	"inosamine-phosphate amidinotransferase"
RHEA:13265	skos:altLabel	"Inosamine-P amidinotransferase"
RHEA:13265	skos:prefLabel	"scyllo-inosamine-4-phosphate amidinotransferase"
RHEA:13265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine
RHEA:13265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scyllo-inosamine-4-phosphate amidinotransferase"
RHEA:13265	skos:altLabel	"L-arginine:inosamine-P-amidinotransferase"
RHEA:13265	skos:altLabel	"L-arginine:inosamine phosphate amidinotransferase"
REACT:R-DRE-5250930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH recruits histone acetyltransferases (Danio rerio)
REACT:R-DDI-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Dictyostelium discoideum)
REACT:R-MMU-1236955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Movement of clathrin coated vesicles into early endosome (Mus musculus)
RHEA:59321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiono-1,5-lactone + H2O => 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)
GO:0047474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acid luciferin component ligase activity
GO:0047474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-fatty-acid luciferin component ligase activity
GO:0047474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-fatty-acid:protein ligase (AMP-forming)
GO:0047474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-fatty-acid-luciferin-component ligase activity
GO:0047474	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-protein synthetase activity
RHEA:36587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldopyranose + NADP(+) = aldono-1,5-lactone + H(+) + NADPH
REACT:R-MMU-391942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP receptor can bind prostacyclin (Mus musculus)
RHEA:16656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + NADP(+) <=> 2-dehydro-D-gluconate + H(+) + NADPH
REACT:R-GGA-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Gallus gallus)
REACT:R-CFA-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Canis familiaris)
RHEA:62687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norrubrofusarin + S-adenosyl-L-methionine <=> H(+) + rubrofusarin + S-adenosyl-L-homocysteine
REACT:R-SSC-140842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n fibrin monomers -> fibrin multimer (Sus scrofa)
RHEA:14415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) => biphenyl-2,3-diol + O2
RHEA:49137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl-[protein] + NADPH + O2 => H2O + L-methionyl-S-oxide-[protein] + NADP(+)
REACT:R-XTR-205328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other tyrosine kinases with p-KIT (Xenopus tropicalis)
RHEA:28400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate
REACT:R-SCE-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)
RHEA:29945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out) => 2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in)
RHEA:51416	skos:prefLabel	"anthocyanidin reductase [(2S)-flavan-3-ol-forming]"
RHEA:51416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH
RHEA:51416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH
RHEA:51416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanidin reductase [(2S)-flavan-3-ol-forming]"
RHEA:33498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate <=> 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate
REACT:R-BTA-376141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ABL with ROBO1:SLIT2 (Bos taurus)
GO:0035647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-delta4,5-steroid 5beta-reductase
GO:0035647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-delta(4,5)-steroid 5-beta-reductase activity
REACT:R-XTR-977363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3bBb (Xenopus tropicalis)
REACT:R-GGA-392530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S400-Cot phosphorylates NIK (Gallus gallus)
RHEA:64261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + glycine => CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine
GO:0102904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacrene C synthase activity
REACT:R-GGA-183089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds and ubiquitinates phosphorylated Sprouty (Gallus gallus)
REACT:R-SSC-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)
REACT:R-MMU-4551724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 (Mus musculus)
RHEA:50771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Danio rerio)
REACT:R-SSC-141431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)
RHEA:43280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate
REACT:R-SSC-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Sus scrofa)
REACT:R-MMU-2213200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of endostatin-like peptides (Mus musculus)
GO:0140061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5hmC dioxygenase
GO:0140061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethylcytosine dioxygenase activity
REACT:R-DME-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Drosophila melanogaster)
REACT:R-HSA-9005585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex (Homo sapiens)
REACT:R-BTA-5654705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
REACT:R-CFA-9009554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer:SDC1 binds CSF1R (Canis familiaris)
REACT:R-HSA-444208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLNR (GPR38) is a receptor for motilin (Homo sapiens)
RHEA:63970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atromentin + 2 H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)
REACT:R-SSC-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Sus scrofa)
RHEA:29380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + H2O => 2'-deoxyguanosine + phosphate
REACT:R-CFA-8944261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIII (Canis familiaris)
REACT:R-CFA-190429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c (Canis familiaris)
REACT:R-BTA-351210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Bos taurus)
RHEA:66353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH
REACT:R-CEL-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Caenorhabditis elegans)
GO:0001965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha-subunit binding
GO:0001965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-alpha protein subunit binding
REACT:R-BTA-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)
REACT:R-HSA-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
REACT:R-SPO-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-MMU-5432825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds TLR4:LY96 (Mus musculus)
REACT:R-CFA-9706315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SH2B3 (Canis familiaris)
RHEA:22294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-3,5-diol + 4 CO2 + 4 CoA => benzoyl-CoA + 3 H(+) + 3 malonyl-CoA
RHEA:51125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine in snRNA => pseudouridine in snRNA
RHEA:33887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"secoisolariciresinol dehydrogenase"
RHEA:33887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 H(+) + 2 NADH
RHEA:33887	skos:prefLabel	"secoisolariciresinol dehydrogenase"
REACT:R-MMU-5694435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 and MIA3 load procollagen VII into COPII vesicles (Mus musculus)
REACT:R-HSA-2990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO1 to UBA2:SAE1 (Homo sapiens)
REACT:R-SSC-5621366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to p-Y65,Y76-FCER1G (Sus scrofa)
REACT:R-MMU-389897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Mus musculus)
REACT:R-XTR-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Xenopus tropicalis)
REACT:R-BTA-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Bos taurus)
REACT:R-HSA-8852580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clusterin binds C5b-C7, C8, C9 (Homo sapiens)
REACT:R-RNO-9645442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Rattus norvegicus)
REACT:R-BTA-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Bos taurus)
REACT:R-SSC-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)
REACT:R-HSA-8939852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 and SP7 bind the UCMA gene promoter (Homo sapiens)
REACT:R-HSA-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Homo sapiens)
RHEA:22272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:22272	skos:altLabel	"CYP716A53v2"
RHEA:22272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protopanaxadiol 6-hydroxylase"
RHEA:22272	skos:altLabel	"protopanaxatriol synthase"
RHEA:22272	skos:prefLabel	"protopanaxadiol 6-hydroxylase"
RHEA:18838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetyltaxuyunnanin C + acetyl-CoA => CoA + taxuyunnanin C
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-1,3-beta-glucanase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kitalase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-1,3-glucanase
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-1,3-beta-glucosidase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	callase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-(1,3)-beta-D-glucanase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-(1->3)-beta-D-glucanase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-glucan glucanohydrolase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan endo-1,3-beta-D-glucosidase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-1,3-beta-D-glucanase
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1->3)-beta-glucan 3-glucanohydrolase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	laminarinase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1->3)-beta-glucan endohydrolase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-glucan 3-glucanohydrolase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	laminaranase activity
GO:0042973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligo-1,3-glucosidase activity
RHEA:42774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine
RHEA:39637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH
RHEA:16863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate => (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine
RHEA:13271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O
REACT:R-CEL-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)
RHEA:27315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 => 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)
GO:0008324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation transmembrane transporter activity
GO:0008324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane cation transporter activity
REACT:R-GGA-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Gallus gallus)
RHEA:34225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypseudooxynicotine + AH2 => 6-hydroxypseudooxynicotine + A + H2O
RHEA:12821	skos:altLabel	"2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase"
RHEA:12821	skos:prefLabel	"deoxyribose-phosphate aldolase"
RHEA:12821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyribose-phosphate aldolase"
RHEA:12821	skos:altLabel	"phosphodeoxyriboaldolase"
RHEA:12821	skos:altLabel	"deoxyriboaldolase"
RHEA:12821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate
REACT:R-MMU-9032798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK3 activates RAC1 (Mus musculus)
REACT:R-CEL-4647594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAHF formation (Caenorhabditis elegans)
REACT:R-BTA-8852580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clusterin binds C5b-C7, C8, C9 (Bos taurus)
REACT:R-HSA-210309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and KIR2DS2 (Homo sapiens)
RHEA:59895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-amino-4-chloropent-4-enoate <=> chloride + H(+) + L-propargylglycine
RHEA:57466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-[(E)-caffeoyl]-beta-D-glucose + UDP => (E)-caffeate + UDP-alpha-D-glucose
REACT:R-RNO-8848316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36 binds IL1RL2 (Rattus norvegicus)
REACT:R-SPO-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Schizosaccharomyces pombe)
RHEA:15950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyoctadecanoate + NAD(+) => 2-oxooctadecanoate + H(+) + NADH
RHEA:42569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-p-cumate + O2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)
REACT:R-SPO-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Schizosaccharomyces pombe)
REACT:R-RNO-9762345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDN:ALB dissociates (Rattus norvegicus)
RHEA:68235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(in) + Na(+)(in) <=> L-cysteine(out) + Na(+)(out)
REACT:R-DME-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Drosophila melanogaster)
RHEA:35628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP
REACT:R-GGA-391943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLT2 binds LTC4,LTD4,LTE4 (Gallus gallus)
REACT:R-GGA-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Gallus gallus)
REACT:R-SPO-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Schizosaccharomyces pombe)
REACT:R-GGA-2514831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP14 (Gallus gallus)
RHEA:19638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-nopaline + H2O + NADP(+) => 2-oxoglutarate + H(+) + L-arginine + NADPH
GO:0090589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-trehalose phosphotransferase system transporter activity
GO:0102524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity
REACT:R-BTA-9018880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Bos taurus)
RHEA:44430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol
REACT:R-MMU-8848993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated KHDRBS1 translocates to the cytosol (Mus musculus)
REACT:R-HSA-9644900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDNF gene expression is stimulated by NPAS4:ARNT2 (Homo sapiens)
REACT:R-DRE-561253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A12 exchanges extracellular urate for cytosolic LACT (Danio rerio)
REACT:R-PFA-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Plasmodium falciparum)
RHEA:45300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl-sphingoid base + H(+) + phosphocholine
REACT:R-MMU-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Mus musculus)
GO:0106408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-di-AMP synthase
GO:0106408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diadenylate cyclase activity
REACT:R-DME-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Drosophila melanogaster)
RHEA:46000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H(+) + tuberculosinyl diphosphate = 1-tuberculosinyladenosine + diphosphate
REACT:R-HSA-4793947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MOGS does not cleave glucose from an N-glycosylated protein (Homo sapiens)
RHEA:19987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + S-formylglutathione => NAD(+) + S-(hydroxymethyl)glutathione
RHEA:17937	skos:prefLabel	"methylglyoxal synthase"
RHEA:17937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylglyoxal synthase"
RHEA:17937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate = methylglyoxal + phosphate
RHEA:69758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzyl)malonyl-CoA + H(+) + O2 <=> (E)-2-aminocinnamoyl-CoA + CO2 + H2O2
REACT:R-SSC-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Sus scrofa)
REACT:R-XTR-977359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to membrane-associated Factor H:C3b (Xenopus tropicalis)
REACT:R-DDI-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Dictyostelium discoideum)
RHEA:11055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 2 H(+) + NADH + O2 <=> 4-aminophenol + CO2 + H2O + NAD(+)
REACT:R-XTR-8948226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Xenopus tropicalis)
GO:0086087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
REACT:R-DRE-6786096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Danio rerio)
RHEA:58879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-GGA-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Gallus gallus)
REACT:R-HSA-8950128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-12 dissociates from Interleukin-12 receptor (Homo sapiens)
RHEA:70001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine(out) + Na(+)(out) => L-threonine(in) + Na(+)(in)
REACT:R-GGA-5250947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH complex binds rDNA promoter (Gallus gallus)
REACT:R-CFA-688137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 is K63 polyubiquitinated (Canis familiaris)
GO:0061632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA lariat debranching enzyme activator activity
REACT:R-PFA-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Plasmodium falciparum)
RHEA:60073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 => 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)
REACT:R-DME-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Drosophila melanogaster)
RHEA:15105	skos:altLabel	"S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase"
RHEA:15105	skos:altLabel	"F 4'-OMT"
RHEA:15105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + S-adenosyl-L-methionine = H(+) + kaempferide + S-adenosyl-L-homocysteine
RHEA:15105	skos:prefLabel	"kaempferol 4'-O-methyltransferase"
RHEA:15105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kaempferol 4'-O-methyltransferase"
EC:4.99.1.7	skos:altLabel	"arylacetaldoxime dehydratase"
EC:4.99.1.7	skos:altLabel	"PAOx dehydratase"
EC:4.99.1.7	skos:prefLabel	"phenylacetaldoxime dehydratase"
EC:4.99.1.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetaldoxime dehydratase"
RHEA:59355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-lactose + O2 <=> H2O2 + lactobiono-1,5-lactone
REACT:R-CFA-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Canis familiaris)
RHEA:18401	skos:altLabel	"CYP71E1"
RHEA:18401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:18401	skos:prefLabel	"4-hydroxyphenylacetaldehyde oxime monooxygenase"
RHEA:18401	skos:altLabel	"4-hydroxybenzeneacetaldehyde oxime monooxygenase"
RHEA:18401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylacetaldehyde oxime monooxygenase"
RHEA:18401	skos:altLabel	"cytochrome P450II-dependent monooxygenase"
RHEA:50412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] = H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)
RHEA:13969	skos:prefLabel	"RNA 3'-terminal-phosphate cyclase (GTP)"
RHEA:13969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RNA 3'-terminal-phosphate cyclase (GTP)"
RHEA:13969	skos:altLabel	"RNA-3'-phosphate cyclase (GTP)"
RHEA:13969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + GTP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP
REACT:R-RNO-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Rattus norvegicus)
REACT:R-SSC-5662613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 exchanges zinc for copper (Sus scrofa)
RHEA:69353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (E)-prop-1-en-1-SO-peroxol => H2O + thiosulfinate
RHEA:60933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-1482696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)
REACT:R-DRE-174174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Danio rerio)
RHEA:66142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyloctopamine => acetyl-CoA + octopamine
RHEA:62666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine => (2'R)-atrovenetin + S-adenosyl-L-methionine
REACT:R-DME-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
REACT:R-RNO-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Rattus norvegicus)
RHEA:71001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Mus musculus)
REACT:R-HSA-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Homo sapiens)
REACT:R-HSA-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Homo sapiens)
RHEA:60718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemate + 2 H(+) + NADPH => (1R,3R)-chrysanthemal + H2O + NADP(+)
REACT:R-XTR-183089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds and ubiquitinates phosphorylated Sprouty (Xenopus tropicalis)
RHEA:60879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)
REACT:R-XTR-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Xenopus tropicalis)
RHEA:12922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H(+) + succinyl-CoA => 5-aminolevulinate + CO2 + CoA
RHEA:13033	skos:prefLabel	"galactose-6-phosphate isomerase"
RHEA:13033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactose-6-phosphate isomerase"
RHEA:13033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-phosphate
REACT:R-BTA-420883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins act as GEFs for G alpha-t (Bos taurus)
REACT:R-RNO-5223305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL, inhibiting it (Rattus norvegicus)
REACT:R-RNO-8948775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKRN1 polyubiquitinates PTEN (Rattus norvegicus)
RHEA:61259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteine + O2 <=> 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)
GO:0019978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-3 binding
GO:0019978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-3 binding
GO:0017070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U6 snRNA binding
REACT:R-DRE-5690870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Danio rerio)
RHEA:26442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + ethanol = a ubiquinol + acetaldehyde
RHEA:26442	skos:altLabel	"PQQ-dependent ADH"
RHEA:26442	skos:altLabel	"pyrroloquinoline quinone-dependent alcohol dehydrogenase"
RHEA:26442	skos:altLabel	"quinoprotein ADH"
RHEA:26442	skos:prefLabel	"alcohol dehydrogenase (quinone)"
RHEA:26442	skos:altLabel	"type III ADH"
RHEA:26442	skos:altLabel	"quinoprotein alcohol dehydrogenase"
RHEA:26442	skos:altLabel	"PQQ alcohol dehydrogenase"
RHEA:26442	skos:altLabel	"PQQ-dependent alcohol dehydrogenase"
RHEA:26442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol dehydrogenase (quinone)"
RHEA:49865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid + 2 a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)
REACT:R-DME-6791109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds PCNA (Drosophila melanogaster)
REACT:R-RNO-9013022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GAPs stimulate RHOB GTPase activity (Rattus norvegicus)
RHEA:52209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Danio rerio)
RHEA:66636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (-)-alpha-acorenol + diphosphate
GO:0005005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane-Eph receptor activity
GO:0005005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane-ephrin receptor activity
REACT:R-HSA-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Homo sapiens)
REACT:R-GGA-9692376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL2 binds BCL2 antagonists (Gallus gallus)
RHEA:44600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP + H(+) = a fatty acyl-AMP + diphosphate
RHEA:55576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine = H(+) + psilocybin + S-adenosyl-L-homocysteine
REACT:R-CFA-8850539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GNB5:RGS dimers from CCT/TRiC (Canis familiaris)
RHEA:33665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2
REACT:R-DRE-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Danio rerio)
REACT:R-CEL-392053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS binds Grb2 bound to pFAK:NCAM1 (Caenorhabditis elegans)
RHEA:31533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + N(omega)-hydroxy-L-arginine + succinate => 2-oxoglutarate + L-arginine + O2
RHEA:17567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine
RHEA:57808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-3-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite
RHEA:56521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine
REACT:R-SSC-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)
RHEA:27360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide + S-adenosyl-L-methionine <=> iodomethane + S-adenosyl-L-homocysteine
REACT:R-RNO-139908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DLC2 by MAPK8 (Rattus norvegicus)
RHEA:60210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate => 3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2
REACT:R-GGA-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Gallus gallus)
RHEA:38235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + octadecan-1-ol = 1-O-octadecyl (9Z)-octadecenoate + CoA
REACT:R-XTR-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Xenopus tropicalis)
GO:0140081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosylated region protein binding
RHEA:12340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)
REACT:R-RNO-6811412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer to the Golgi (Rattus norvegicus)
REACT:R-SSC-416725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA6D binds to PLXNA1:TREM2:DAP12 (Sus scrofa)
REACT:R-SSC-9667914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand midkine (MDK) (Sus scrofa)
REACT:R-XTR-2327695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Xenopus tropicalis)
RHEA:10045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanol + NAD(+) => cyclohexanone + H(+) + NADH
RHEA:44676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + all-trans-retinol = a diacylglycerol + an all-trans-retinyl ester
REACT:R-HSA-1980074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 (Homo sapiens)
RHEA:71292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) => (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)
REACT:R-CFA-6798258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTPRF, PTPRS, PTPRD bind LRRC4B (Canis familiaris)
REACT:R-SCE-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-DRE-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Danio rerio)
RHEA:22381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O => [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol
RHEA:34401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-10'-apo-beta-carotenal + beta-ionone => 9-cis-beta-carotene + O2
REACT:R-XTR-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Xenopus tropicalis)
GO:0018451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxide dehydrogenase activity
RHEA:24444	skos:altLabel	"GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase"
RHEA:24444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]
RHEA:24444	skos:altLabel	"GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase"
RHEA:24444	skos:prefLabel	"glycoprotein 3-alpha-L-fucosyltransferase"
RHEA:24444	skos:altLabel	"GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase"
RHEA:24444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycoprotein 3-alpha-L-fucosyltransferase"
REACT:R-CFA-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Canis familiaris)
REACT:R-MMU-450620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S193-KSRP binds 14-3-3zeta in the nucleus (Mus musculus)
REACT:R-XTR-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Xenopus tropicalis)
RHEA:10225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyridoxal => ADP + H(+) + pyridoxal 5'-phosphate
RHEA:61856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 = betaenone C + 3 H2O + 3 NADP(+)
GO:0047220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosylxylosylprotein 3-beta-galactosyltransferase activity
GO:0047220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity
GO:0047220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosyltransferase II activity
GO:0047220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity
GO:0047220	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-galactosylxylose galactosyltransferase activity
GO:0047220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker (Homo sapiens)
RHEA:72430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + K(+)(in) <=> chloride(out) + K(+)(out)
GO:0103062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-keto-C60-meroacyl-AMP ligase activity
RHEA:53447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:19761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-N(5)-oxide + H(+) + NADH = FMN + H2O + NAD(+)
GO:0030377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U-plasminogen activator receptor activity
GO:0030377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR
GO:0030377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator receptor activity
GO:0030377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator receptor
RHEA:37408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA
REACT:R-HSA-9700646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASP-3026- resistant ALK mutants don't bind ASP-3026 (Homo sapiens)
RHEA:14166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-aspartate => CoA + H(+) + N-acetyl-L-aspartate
REACT:R-CEL-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Caenorhabditis elegans)
RHEA:50120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-taurine
REACT:R-HSA-5096537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GALNT3 does not transfer GalNAc to mucins (Homo sapiens)
REACT:R-CEL-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Caenorhabditis elegans)
RHEA:68993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4-hydroxybenzoate + H(+) + NADPH + O2 => 3-amino-2,4-dihydroxybenzoate + H2O + NADP(+)
RHEA:53794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzothialdehyde + H2O2 => benzylthiol + O2
REACT:R-CFA-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Canis familiaris)
RHEA:60908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in tRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:26451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NADP(+) + succinate semialdehyde => H(+) + NADPH + succinyl-CoA
RHEA:45634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O
RHEA:30944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + octanoyl-CoA => (2E)-octenoyl-CoA + FADH2
GO:0017058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FH1 domain binding
RHEA:20881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxydecanoate + NAD(+) => 10-oxodecanoate + H(+) + NADH
REACT:R-MMU-8854905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)
REACT:R-HSA-8953037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F8 forms homodimers (Homo sapiens)
REACT:R-HSA-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Homo sapiens)
GO:0103037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glyceraldehyde 3-phosphate reductase activity
REACT:R-SSC-879942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor is activated (Sus scrofa)
REACT:R-CFA-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Canis familiaris)
RHEA:42847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH <=> 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide
REACT:R-CEL-9663492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL dissociates from GSTA1, FABP1 (Caenorhabditis elegans)
RHEA:55091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eburicol + S-adenosyl-L-methionine <=> (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
REACT:R-HSA-8867240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPCAM binds itself to form homotypic cell adhesion (Homo sapiens)
RHEA:19434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-gluconate => 6-phospho-D-gluconate + ADP + H(+)
RHEA:70604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxystyrene + H(+) + NADH => 4-ethylphenol + NAD(+)
RHEA:41846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-[ACP] + H2O => (3R)-hydroxyoctanoyl-[ACP]
RHEA:37538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-DME-193143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)
REACT:R-RNO-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Rattus norvegicus)
REACT:R-DME-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Drosophila melanogaster)
REACT:R-BTA-5685902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Bos taurus)
REACT:R-MMU-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Mus musculus)
REACT:R-XTR-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Xenopus tropicalis)
REACT:R-MMU-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Mus musculus)
REACT:R-RNO-199839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate RSK (Rattus norvegicus)
RHEA:70682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(in) + H(+)(in) <=> glycine betaine(out) + H(+)(out)
REACT:R-GGA-170843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 phosphorylates TGFBR1 (Gallus gallus)
REACT:R-MMU-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Mus musculus)
REACT:R-DRE-3640858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase ADP-ribosylates AXIN (Danio rerio)
RHEA:41940	skos:prefLabel	"[amino-group carrier protein]--L-2-aminoadipate ligase"
RHEA:41940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[amino-group carrier protein]--L-2-aminoadipate ligase"
RHEA:41940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate = [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate
RHEA:41940	skos:altLabel	"AAA--LysW ligase"
RHEA:41940	skos:altLabel	"alpha-aminoadipate-lysW ligase"
REACT:R-BTA-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Bos taurus)
GO:0016907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metabotropic acetylcholine receptor activity
GO:0016907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	muscarinic acetylcholine receptor activity
GO:0016907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled acetylcholine receptor activity
GO:0016907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine receptor activity, G-protein coupled
GO:0016907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled acetylcholine receptor activity
GO:0016907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled acetylcholine receptor activity
RHEA:24324	skos:prefLabel	"6-oxocineole dehydrogenase"
RHEA:24324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-oxocineole dehydrogenase"
RHEA:24324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocineole + H(+) + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)
RHEA:36966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA
REACT:R-DRE-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Danio rerio)
REACT:R-CEL-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Caenorhabditis elegans)
RHEA:69864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in mRNA + S-adenosyl-L-methionine => a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Gallus gallus)
RHEA:64350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylpyripyropene E => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+)
RHEA:10684	skos:altLabel	"phosphotyrosine phosphatase"
RHEA:10684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
RHEA:10684	skos:prefLabel	"protein-tyrosine-phosphatase"
RHEA:10684	skos:altLabel	"PTPase"
RHEA:10684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-tyrosine-phosphatase"
REACT:R-CFA-193668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR and RHOA-GDI interact (Canis familiaris)
REACT:R-CEL-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
EC:2.3.1.134	skos:prefLabel	"galactolipid O-acyltransferase"
EC:2.3.1.134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactolipid O-acyltransferase"
EC:2.3.1.134	skos:altLabel	"galactolipid:galactolipid acyltransferase"
RHEA:67252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonaldehyde + NAD(+) = 3-oxopropanoate + 2 H(+) + NADH
REACT:R-DME-5624486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylates RAF1 on Y340,Y341 (Drosophila melanogaster)
REACT:R-SCE-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Saccharomyces cerevisiae)
REACT:R-XTR-202713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD84 homodimerises (Xenopus tropicalis)
REACT:R-DRE-1475026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (cytosol) (Danio rerio)
REACT:R-HSA-9625124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCK gene expression is inhibited by FOXO1, SIN3A and HDACs (Homo sapiens)
REACT:R-XTR-201521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK autophosphorylation downstream of PTN and MDK (Xenopus tropicalis)
RHEA:43740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA
RHEA:14201	skos:prefLabel	"D-lyxose ketol-isomerase"
RHEA:14201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-lyxose ketol-isomerase"
RHEA:14201	skos:altLabel	"D-lyxose isomerase"
RHEA:14201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lyxose = D-xylulose
GO:0022859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dephosphorylation-gated channel activity
REACT:R-GGA-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Gallus gallus)
RHEA:67222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+)
RHEA:28404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A
RHEA:42917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine
REACT:R-SSC-964811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5AR2 binds anaphylatoxins and thier desArginated derivatives (Sus scrofa)
RHEA:45566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-epi-valiolone => 2-epi-5-epi-valiolone
REACT:R-DRE-194678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 demethylates LNSOL (Danio rerio)
REACT:R-MMU-192123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates CHOL (Mus musculus)
RHEA:39692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH => (11Z)-octadecenoyl-CoA + NADP(+)
GO:0052821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-7-methyladenine glycosylase activity
REACT:R-CEL-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Caenorhabditis elegans)
GO:0047876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoglycosylceramidase activity
GO:0047876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoglycoceramidase activity
GO:0047876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity
GO:0047876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligoglycosylglucosylceramide glycohydrolase activity
GO:0047876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-glucosylceramidase activity
GO:0047876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	EGCase activity
RHEA:14031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + selenate => A + H2O + selenite
REACT:R-RNO-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Rattus norvegicus)
REACT:R-DRE-5689972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 deubiquitinates MDM2,MDM4 (Danio rerio)
RHEA:43717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate => [glutamine synthetase]-L-tyrosine + ADP
RHEA:12694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxypyridine + O-acetyl-L-serine => 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)
RHEA:39590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)
REACT:R-HSA-9618392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-26 binds to the 3'UTR of the ARL4C mRNA (Homo sapiens)
REACT:R-DRE-5340320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTP transports GSL from plasma membrane to ER membrane (Danio rerio)
REACT:R-RNO-5218841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)
RHEA:71910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide
RHEA:25502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + terpinolene => (2E)-geranyl diphosphate
REACT:R-GGA-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Gallus gallus)
RHEA:29871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + thiosulfate(out) = ADP + H(+) + phosphate + thiosulfate(in)
RHEA:18493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine N-benzoyltransferase"
RHEA:18493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + glycine = CoA + H(+) + N-benzoylglycine
RHEA:18493	skos:prefLabel	"glycine N-benzoyltransferase"
REACT:R-MMU-374909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabolism of Noradrenaline (Mus musculus)
REACT:R-DRE-5627275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOPC promotes translocation of CFTR to lysosomes (Danio rerio)
REACT:R-SPO-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Schizosaccharomyces pombe)
RHEA:10787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate
REACT:R-HSA-2586559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Leptin Binds Leptin Receptor (Homo sapiens)
RHEA:44647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)
REACT:R-SSC-8866542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Sus scrofa)
RHEA:44039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,13-epoxy-(9Z)-octadecenoate + H2O <=> 12,13-dihydroxy-(9Z)-octadecenoate
RHEA:36860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA
RHEA:49150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine
REACT:R-RNO-6807106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN undergoes monoubiquitination (Rattus norvegicus)
RHEA:47626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline-2-carboxylate + H2O => cis-3-hydroxy-L-proline
RHEA:14599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + choline
RHEA:37268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-aspartate => L-alanine + L-aspartate
REACT:R-PFA-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Plasmodium falciparum)
REACT:R-BTA-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Bos taurus)
REACT:R-CFA-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)
REACT:R-DME-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Drosophila melanogaster)
REACT:R-SCE-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Saccharomyces cerevisiae)
RHEA:24219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesal + H2O + NAD(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADH
REACT:R-DDI-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Dictyostelium discoideum)
REACT:R-MMU-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Mus musculus)
GO:0047376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
GO:0047376	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	all-trans-retinyl-palmitate acylhydrolase activity
GO:0047376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NREH hydrolyses atREs to atROL and FAs (Homo sapiens)
GO:0047376	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinyl-palmitate palmitohydrolase activity
GO:0047376	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	all-trans-retinyl-palmitate hydrolase activity
REACT:R-SCE-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Saccharomyces cerevisiae)
REACT:R-XTR-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Xenopus tropicalis)
RHEA:11921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O
REACT:R-GGA-1236958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of particulate antigens with dendritic cell receptors (Gallus gallus)
RHEA:30638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:14913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + thymidine = adenosine + dTMP
RHEA:14913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"AMP--thymidine kinase"
RHEA:14913	skos:prefLabel	"AMP--thymidine kinase"
RHEA:14913	skos:altLabel	"adenylate-nucleoside phosphotransferase"
RHEA:26379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic pyranopterin phosphate + diphosphate => GTP
REACT:R-RNO-8950342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBI3:CANX binds IL27 (Rattus norvegicus)
REACT:R-HSA-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Homo sapiens)
REACT:R-HSA-9697070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lprG dissociates from LAM,LM (Homo sapiens)
REACT:R-SSC-5691150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFR2 dimer binds 2xholoTF (Sus scrofa)
RHEA:56351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)
REACT:R-SPO-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)
REACT:R-DME-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Drosophila melanogaster)
REACT:R-GGA-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Gallus gallus)
RHEA:12107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP <=> 7,8-dihydrofolate + dTMP
REACT:R-RNO-8938108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds cathepsin L (Rattus norvegicus)
REACT:R-CEL-8939801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades PolyUb-RUNX2 (Caenorhabditis elegans)
RHEA:25350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tyrosyl-tRNA(Tyr) + H2O <=> D-tyrosine + tRNA(Tyr)
RHEA:24104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine
RHEA:24104	skos:prefLabel	"tRNA-guanosine(34) preQ1 transglycosylase"
RHEA:24104	skos:altLabel	"guanine insertion enzyme"
RHEA:24104	skos:altLabel	"TGT"
RHEA:24104	skos:altLabel	"tRNA transglycosylase"
RHEA:24104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-guanosine(34) preQ1 transglycosylase"
RHEA:24104	skos:altLabel	"Q-insertase"
RHEA:24104	skos:altLabel	"tRNA guanine(34) transglycosidase"
GO:0000772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mating pheromone activity
REACT:R-MMU-8852509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL-LK binds carbohydrates on target cell surface (Mus musculus)
REACT:R-SSC-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Sus scrofa)
REACT:R-MMU-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Mus musculus)
REACT:R-BTA-3247569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADI4 deiminates Histones (Bos taurus)
GO:0031544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-proline 3-dioxygenase activity
RHEA:60464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
RHEA:17880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a catechol + S-adenosyl-L-methionine <=> a guaiacol + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-162830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)
RHEA:28340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonobetainyl-CoA + H2O => (R)-carnitinyl-CoA
RHEA:44227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoate + ATP + CoA <=> 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate
REACT:R-DRE-2105001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from DS (Danio rerio)
REACT:R-HSA-9769316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds NAMPT gene promoter (Homo sapiens)
REACT:R-MMU-159843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)
REACT:R-CEL-2032770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1 to the nucleus (Caenorhabditis elegans)
GO:0033407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCA codon-amino acid adaptor activity
GO:0033407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine tRNA
GO:0033407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCA codon-amino acid adaptor activity
RHEA:58085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(13Z-docosenoyl)-glycerol + H2O => (13Z)-docosenoate + glycerol + H(+)
RHEA:30793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGDP + H(+) + phosphoenolpyruvate => dGTP + pyruvate
EC:2.7.11.17	skos:altLabel	"Ca(2+)/calmodulin-dependent protein kinase kinase beta"
EC:2.7.11.17	skos:altLabel	"CaMKKalpha"
EC:2.7.11.17	skos:altLabel	"calmodulin-dependent kinase II"
EC:2.7.11.17	skos:altLabel	"CaMKII"
EC:2.7.11.17	skos:altLabel	"CaMKI"
EC:2.7.11.17	skos:altLabel	"CaMKIV"
EC:2.7.11.17	skos:altLabel	"CaM-regulated serine/threonine kinase"
EC:2.7.11.17	skos:altLabel	"Ca(2+)/calmodulin-dependent protein kinase 1"
EC:2.7.11.17	skos:altLabel	"Ca(2+)/calmodulin-dependent protein kinase kinase"
EC:2.7.11.17	skos:altLabel	"caldesmon kinase"
EC:2.7.11.17	skos:altLabel	"Ca(2+)/calmodulin-dependent protein kinase II"
EC:2.7.11.17	skos:altLabel	"CaM kinase II"
EC:2.7.11.17	skos:altLabel	"calcium/calmodulin-dependent protein kinase type II"
EC:2.7.11.17	skos:altLabel	"CaM kinase"
EC:2.7.11.17	skos:altLabel	"Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase"
EC:2.7.11.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"calcium/calmodulin-dependent protein kinase"
EC:2.7.11.17	skos:altLabel	"CAM PKII"
EC:2.7.11.17	skos:altLabel	"microtubule-associated protein 2 kinase"
EC:2.7.11.17	skos:altLabel	"Ca(2+)/calmodulin-dependent protein kinase IV"
EC:2.7.11.17	skos:altLabel	"caldesmon kinase (phosphorylating)"
EC:2.7.11.17	skos:prefLabel	"calcium/calmodulin-dependent protein kinase"
EC:2.7.11.17	skos:altLabel	"CaMKKbeta"
REACT:R-CFA-74247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Canis familiaris)
REACT:R-XTR-8987040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Xenopus tropicalis)
REACT:R-MMU-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Mus musculus)
REACT:R-BTA-173740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to C3(H2O) (Bos taurus)
REACT:R-CEL-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)
REACT:R-HSA-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)
RHEA:44763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:42898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine => L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine
REACT:R-PFA-5618110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Plasmodium falciparum)
RHEA:33935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide
RHEA:67863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] <=> 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)
GO:0102224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity
REACT:R-SSC-9708536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 translocates from the cytosol to the nucleoplasm (Sus scrofa)
RHEA:27854	skos:prefLabel	"4-hydroxybenzoate geranyltransferase"
RHEA:27854	skos:altLabel	"p-hydroxybenzoate geranyltransferase"
RHEA:27854	skos:altLabel	"4HB geranyltransferase"
RHEA:27854	skos:altLabel	"PHB geranyltransferase"
RHEA:27854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoate geranyltransferase"
RHEA:27854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate
RHEA:55260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:69079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline + H2O + O2 <=> (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)
REACT:R-RNO-163217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Rattus norvegicus)
RHEA:52746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-isomaltosyl-(1->3)-isomaltose => cyclobis-(1->3)-alpha-D-isomaltosyl + H2O
REACT:R-HSA-8944246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXI (Homo sapiens)
GO:0086075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in cardiac conduction electrical coupling
RHEA:34468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + valerena-4,7(11)-diene
EC:3.1.6.4	skos:altLabel	"chondroitinase"
EC:3.1.6.4	skos:altLabel	"galactose-6-sulfate sulfatase"
EC:3.1.6.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylgalactosamine-6-sulfatase"
EC:3.1.6.4	skos:prefLabel	"N-acetylgalactosamine-6-sulfatase"
EC:3.1.6.4	skos:altLabel	"chondroitinsulfatase"
REACT:R-BTA-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Bos taurus)
REACT:R-DRE-9696266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds effectors (Danio rerio)
REACT:R-MMU-914018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Mus musculus)
GO:1990259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-glutamine methyltransferase activity
GO:1990259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-glutamine N-methyltransferase activity
GO:1990259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone glutamine methyltransferase activity
GO:1990259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone glutamine methylase activity
GO:1990259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone glutamine N-methyltransferase activity
REACT:R-HSA-5655343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 mutants bind PLCG1 (Homo sapiens)
REACT:R-HSA-2077424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)
REACT:R-SCE-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Saccharomyces cerevisiae)
REACT:R-SPO-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Schizosaccharomyces pombe)
RHEA:13070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + ethanolamine => ADP + H(+) + phosphoethanolamine
GO:0102173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecycloartanol 4alpha-methyl oxidase activity
RHEA:72518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + glutarate(in) <=> (R)-carnitine(in) + glutarate(out)
RHEA:43873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oate + ATP + CoA => 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate
RHEA:43506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diformylfuran + H2O2 => 5-hydroxymethylfurfural + O2
REACT:R-SSC-109470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Sus scrofa)
REACT:R-MMU-159179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)
RHEA:19397	skos:prefLabel	"phosphopantothenate--cysteine ligase (CTP)"
RHEA:19397	skos:altLabel	"phosphopantothenoylcysteine synthetase"
RHEA:19397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphopantothenate--cysteine ligase (CTP)"
RHEA:19397	skos:altLabel	"phosphopantothenate--cysteine ligase"
RHEA:19397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
REACT:R-HSA-3209165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ID1 sequesters ETS2 (Homo sapiens)
REACT:R-MMU-9676160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds NOD2 (Mus musculus)
GO:0070280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal binding
REACT:R-RNO-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Rattus norvegicus)
RHEA:35156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4,5-dihydroxypentane-2,3-dione => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one
RHEA:48107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
RHEA:43423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-CFA-2426259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Canis familiaris)
GO:0016992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoate synthase activity
GO:0016992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoic acid synthase
GO:0016992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity
GO:0016992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LS
GO:0016992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoyl synthase activity
GO:0016992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity
GO:0016992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LipA
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosaminic dehydrase activity
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminodeoxygluconate ammonia-lyase activity
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminate ammonia-lyase activity
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-2-deoxy-D-gluconate ammonia-lyase activity
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucosaminate ammonia-lyase activity
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucosaminate dehydratase activity
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminodeoxygluconate dehydratase activity
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylenemonocarboxylic acid hydrase activity
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucosaminic acid dehydrase activity
GO:0047930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)
REACT:R-HSA-5658430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF1 is degraded by the proteasome (Homo sapiens)
REACT:R-SSC-209055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)
RHEA:68904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + ATP + H(+) + NADPH = 3-phenylpropanal + AMP + diphosphate + NADP(+)
GO:1902557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-adenylyl sulfate transmembrane transporter activity
RHEA:71321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-cysteine(in) + 2 Na(+)(in) => chloride(out) + L-cysteine(out) + 2 Na(+)(out)
REACT:R-HSA-217255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO1:FAD N-oxidises TAM (Homo sapiens)
REACT:R-MMU-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Mus musculus)
REACT:R-DRE-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Danio rerio)
RHEA:57431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anisole + O2 + reduced [NADH--hemoprotein reductase] <=> formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol
REACT:R-CEL-5661240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCXR tetramer reduces L-xylulose to xylitol (Caenorhabditis elegans)
RHEA:37071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine
REACT:R-BTA-8857662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Bos taurus)
REACT:R-HSA-9617217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-CREB1 binds the promoter of the CEBPB gene (Homo sapiens)
REACT:R-MMU-5693608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial resection of double-strand break ends (Mus musculus)
RHEA:47499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH
REACT:R-CEL-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Caenorhabditis elegans)
REACT:R-DME-163217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Drosophila melanogaster)
REACT:R-DME-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Drosophila melanogaster)
REACT:R-BTA-202478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction and oligomerization of MALT1 to Bcl10 (Bos taurus)
REACT:R-CFA-1370505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR is phosphorylated at Ser-349 (Canis familiaris)
RHEA:47065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SPO-5693549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Schizosaccharomyces pombe)
RHEA:40964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 2-aminophenol + 3 O2 => 2 2-aminophenoxazin-3-one + 6 H2O
REACT:R-DME-2046298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to a branch of keratan (Drosophila melanogaster)
REACT:R-DME-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Drosophila melanogaster)
REACT:R-RNO-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Rattus norvegicus)
REACT:R-GGA-9749977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A6 glucuronates ST (Gallus gallus)
REACT:R-BTA-199112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRTAM binds to NECL2 (Bos taurus)
REACT:R-SSC-391933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP3 receptor can bind PGE2 (Sus scrofa)
RHEA:45047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 <=> 2 Fe(III)-[cytochrome c] + H2O + nitrite
RHEA:18232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + NAD(+) <=> glyoxylate + H(+) + NADH
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1,3)-beta-glucan (callose) synthase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-glucan synthase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-1,3-beta-D-glucan glucosyltransferase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-beta-D-glucan synthase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-glucan-uridine diphosphoglucosyltransferase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	callose synthase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-glucan-UDP glucosyltransferase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	callose synthetase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-1,3-beta-glucan glucosyltransferase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GS-II
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,3-glucan synthase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	paramylon synthetase
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-beta-glucan glucosyltransferase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:(1,3)beta-glucan synthase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,3-glucan synthetase activity
GO:0003843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-glucan synthetase activity
REACT:R-CFA-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Canis familiaris)
REACT:R-HSA-9024973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1 (Homo sapiens)
RHEA:53603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
RHEA:26111	skos:prefLabel	"UDP-N-acetylglucosamine 4,6-dehydratase (inverting)"
RHEA:26111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
RHEA:26111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine 4,6-dehydratase (inverting)"
RHEA:26111	skos:altLabel	"UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase"
REACT:R-SCE-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Saccharomyces cerevisiae)
RHEA:25266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + H2O + O2 => 2-phenylacetaldehyde + H2O2 + NH4(+)
GO:0005346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine ribonucleotide transmembrane transporter activity
REACT:R-GGA-429571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Gallus gallus)
RHEA:33553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + sphinganine => an N-acylsphinganine + H2O
REACT:R-RNO-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Rattus norvegicus)
RHEA:45420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-DME-9726875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCNs:cAMP bind SNIs (Drosophila melanogaster)
REACT:R-DRE-170843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 phosphorylates TGFBR1 (Danio rerio)
REACT:R-RNO-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Rattus norvegicus)
RHEA:44785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-10 + S-adenosyl-L-methionine => H(+) + menaquinol-10 + S-adenosyl-L-homocysteine
RHEA:58948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
RHEA:25182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + putrescine => CoA + H(+) + N-acetylputrescine
REACT:R-RNO-1369028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid efflux (Rattus norvegicus)
GO:0018498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity
REACT:R-DRE-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Danio rerio)
RHEA:70547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP
RHEA:16997	skos:prefLabel	"petromyzonol sulfotransferase"
RHEA:16997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"petromyzonol sulfotransferase"
RHEA:16997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:16997	skos:altLabel	"PZ-SULT"
REACT:R-MMU-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Mus musculus)
REACT:R-HSA-381446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
REACT:R-HSA-264679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serum albumin binds 2-lysophosphatidylcholine (Homo sapiens)
REACT:R-DME-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Drosophila melanogaster)
REACT:R-HSA-8866327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL translocates from SER lumen to extracellular region (Homo sapiens)
REACT:R-MMU-193407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
REACT:R-XTR-917987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFRC dimer binds 2xholoTF (Xenopus tropicalis)
REACT:R-DRE-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Danio rerio)
REACT:R-DME-174171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A with the APC/C (Drosophila melanogaster)
RHEA:31949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-419003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Nectins with Afadin (Bos taurus)
REACT:R-SSC-5682598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates HERC2 (Sus scrofa)
GO:0047459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-aminobutyryl-CoA ammonia-lyase activity
GO:0047459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)
GO:0047459	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-aminobutyryl-CoA deaminase activity
GO:0047459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminobutyryl-CoA ammonia-lyase activity
REACT:R-HSA-202144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
GO:0008116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGI2 synthetase activity
GO:0008116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostacycline synthetase activity
GO:0008116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGI(2) synthetase activity
GO:0008116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostagladin I2 synthetase activity
GO:0008116	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP8A1
GO:0008116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin-I synthase activity
GO:0008116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGI2 synthase activity
GO:0008116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity
GO:0008116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGI(2) synthase activity
GO:0008116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostacyclin synthase activity
REACT:R-MMU-8982645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRKs bind ADRB2:Catecholamine (Mus musculus)
RHEA:63576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone 22-phosphate + H2O = ecdysone + phosphate
REACT:R-CFA-8853405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 binds AURKA at centrosomes (Canis familiaris)
RHEA:41145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O
REACT:R-DME-6797913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARDH:FAD oxidatively demethylates SARC to Gly (Drosophila melanogaster)
REACT:R-CFA-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Canis familiaris)
REACT:R-DDI-5693925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers L-fucose to Gal1,3GlcNAc (Dictyostelium discoideum)
REACT:R-RNO-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Rattus norvegicus)
GO:0004668	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-L-arginine iminohydrolase activity
GO:0004668	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidylarginine deiminase activity
GO:0004668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine deiminase activity
REACT:R-SPO-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Schizosaccharomyces pombe)
RHEA:65099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + hexadecanoyl-CoA <=> a 1-hexadecanoyl-2-acylglycerol + CoA
RHEA:48064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate
RHEA:58749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethylnectriapyrone + S-adenosyl-L-methionine => H(+) + nectriapyrone + S-adenosyl-L-homocysteine
REACT:R-BTA-5669035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF11 binds TNFRSF11A, B (Bos taurus)
REACT:R-CEL-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)
REACT:R-HSA-9022935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds GAD1 gene promoter (Homo sapiens)
RHEA:33751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
RHEA:33751	skos:prefLabel	"phosphatidylglycerophosphatase"
RHEA:33751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylglycerophosphatase"
GO:0047548	skos:prefLabel	"2-methyleneglutarate mutase"
GO:0047548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methyleneglutarate mutase"
GO:0047548	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methyleneglutarate carboxy-methylenemethylmutase activity
GO:0047548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyleneglutarate = 2-methylene-3-methylsuccinate
GO:0047548	skos:altLabel	"alpha-methyleneglutarate mutase"
GO:0047548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyleneglutarate mutase activity
GO:0047548	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-methyleneglutarate mutase activity
RHEA:22372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-aci-nitropropanoate oxidase"
RHEA:22372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + propionate 3-nitronate = 3-oxopropanoate + H(+) + H2O2 + nitrite
RHEA:22372	skos:prefLabel	"3-aci-nitropropanoate oxidase"
RHEA:37220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-valine + H2O => 3-methyl-2-oxobutanoate + AH2 + NH4(+)
GO:1990107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity
GO:1990107	skos:prefLabel	"thiazole synthase"
GO:1990107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O
GO:1990107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiazole synthase"
GO:1990107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiazole synthase activity
REACT:R-DRE-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Danio rerio)
REACT:R-MMU-74740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SHC1 to insulin receptor (Mus musculus)
RHEA:56826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cyclooctatin + H2O => AH2 + cyclooctat-9-ene-5,7-diol + O2
REACT:R-GGA-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Gallus gallus)
RHEA:57544	skos:altLabel	"CYP71Z18"
RHEA:57544	skos:prefLabel	"zealexin A1 synthase"
RHEA:57544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1
RHEA:57544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zealexin A1 synthase"
RHEA:49741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NADP(+)
RHEA:46589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcidiol + H2O + 2 oxidized [adrenodoxin]
RHEA:14284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + sulfite <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate
RHEA:58584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate = (-)-tabersonine + acetate + H(+)
RHEA:28453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-psicosyl)-L-lysine(in) <=> N(6)-(D-psicosyl)-L-lysine(out)
RHEA:45896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)
RHEA:29176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 O2 + ubiquinol-8 => 2 H(+) + 2 superoxide + ubiquinone-8
REACT:R-DME-2213240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of disulphide bonds in MHC II antigens (Drosophila melanogaster)
REACT:R-RNO-71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Rattus norvegicus)
REACT:R-HSA-4332388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MAP3K7 in response to WNT (Homo sapiens)
RHEA:50486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein]
REACT:R-RNO-264976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Rattus norvegicus)
REACT:R-RNO-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Rattus norvegicus)
RHEA:32659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-hydroxygeraniol dehydrogenase"
RHEA:32659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + 2 NADP(+) = (6E)-8-oxogeranial + 2 H(+) + 2 NADPH
RHEA:32659	skos:prefLabel	"8-hydroxygeraniol dehydrogenase"
RHEA:32659	skos:altLabel	"CYP76B10"
RHEA:32659	skos:altLabel	"8-hydroxygeraniol oxidoreductase"
RHEA:49538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O => 2-amino-2-deoxy-D-gluconate
RHEA:20322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NAD(+) => 1-pyrroline-2-carboxylate + H(+) + NADH
REACT:R-RNO-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Rattus norvegicus)
REACT:R-XTR-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Xenopus tropicalis)
RHEA:11756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]
RHEA:11756	skos:altLabel	"biotin--[acetyl-CoA-carboxylase] ligase"
RHEA:11756	skos:altLabel	"biotin--protein ligase"
RHEA:11756	skos:prefLabel	"biotin--[biotin carboxyl-carrier protein] ligase"
RHEA:11756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biotin--[biotin carboxyl-carrier protein] ligase"
RHEA:11756	skos:altLabel	"acetyl-CoA carboxylase biotin holoenzyme synthetase"
RHEA:11756	skos:altLabel	"biotin--[acetyl-CoA carboxylase] synthetase"
RHEA:20854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + 2 H(+)(out) + phosphate => ATP + H(+)(in) + H2O
GO:0102939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-5-hydroxytoluene O-methyltransferase activity
REACT:R-DRE-5651789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to POLB ligates SSB (Danio rerio)
RHEA:39136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2
REACT:R-SPO-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Schizosaccharomyces pombe)
REACT:R-DRE-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Danio rerio)
REACT:R-DRE-3785684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by CTSG (Danio rerio)
REACT:R-DRE-450490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B/Akt phosphorylates BRF1 (Danio rerio)
REACT:R-RNO-5672957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates KSR1 (Rattus norvegicus)
RHEA:24425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + L-dehydroascorbate => glutathione disulfide + L-ascorbate
RHEA:31081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-butenoyl-CoA + H2O => 3-hydroxyisovaleryl-CoA
REACT:R-MMU-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Mus musculus)
REACT:R-PFA-2161999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Plasmodium falciparum)
RHEA:62804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 7-demethylsiderin + NADPH + O2 = desertorin A + 2 H2O + NADP(+)
REACT:R-MMU-139855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X1-mediated entry of Ca++ from plasma (Mus musculus)
RHEA:36149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl acetate + CoA => acetyl-CoA + benzyl alcohol
RHEA:51578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phlorizin + UDP => phloretin + UDP-alpha-D-glucose
RHEA:50795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> aldosterone + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-SCE-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Saccharomyces cerevisiae)
REACT:R-XTR-2467665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds Beta amyloid fibril via GAG chains (Xenopus tropicalis)
REACT:R-CFA-8852337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds TP53 (Canis familiaris)
RHEA:49377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:61656	skos:prefLabel	"farnesol kinase"
RHEA:61656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"farnesol kinase"
RHEA:61656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + ATP = (2E,6E)-farnesyl phosphate + ADP + H(+)
RHEA:53862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrocholate + H(+) + NADPH => 7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+)
REACT:R-RNO-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Rattus norvegicus)
REACT:R-DRE-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Danio rerio)
RHEA:55852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA
GO:2001067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pullulan binding
RHEA:69851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + H(+) + NADH
GO:0031875	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 4 proteinase activated receptor ligand
GO:0031875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 4 proteinase activated receptor binding
REACT:R-DRE-430190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds NCK (Danio rerio)
REACT:R-GGA-2029457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIIA with IgG-coated Ag (Gallus gallus)
RHEA:65725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + pentyl sulfate => CO2 + H(+) + pentanal + succinate + sulfate
REACT:R-RNO-417898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y4 receptor can bind to UTP (Rattus norvegicus)
REACT:R-CEL-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)
REACT:R-SSC-1028820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of VAF (virus-activated factor) complex (Sus scrofa)
REACT:R-HSA-196402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Homo sapiens)
REACT:R-GGA-3640862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase binds AXIN (Gallus gallus)
RHEA:18423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloramphenicol 3-acetate + CoA => acetyl-CoA + chloramphenicol
RHEA:49590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose 4-phosphate => L-erythrulose 1-phosphate
GO:0052666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA cytosine-2'-O-methyltransferase activity
GO:0052666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:tRNA cytosine-2'-O-methyltransferase activity
GO:0052666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:tRNA (cytosine-2'-O-)-methyltransferase activity
GO:0052666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT13 2'-O-methylates adenosine-4 in tRNA (Homo sapiens)
GO:0052666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transfer ribonucleate cytosine 2'-methyltransferase activity
GO:0052666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (cytosine-2'-O-)-methyltransferase activity
GO:0052666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA cytosine 2'-methyltransferase activity
GO:0052666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (cytosine 2')-methyltransferase activity
REACT:R-XTR-8856808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of AP-2 complex and clathrin (Xenopus tropicalis)
RHEA:65614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:72386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + urate(in) <=> Na(+)(in) + urate(out)
RHEA:65547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc
GO:0036243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate-semialdehyde dehydrogenase (NADP+) activity
GO:0036243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinic semialdehyde dehydrogenase (NADP+) activity
GO:0036243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent succinate-semialdehyde dehydrogenase activity
GO:0036243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl semialdehyde dehydrogenase (NADP+) activity
GO:0036243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate semialdehyde:NADP+ oxidoreductase activity
RHEA:69916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(out) + 2 Na(+)(out) => guanosine(in) + 2 Na(+)(in)
REACT:R-CFA-8866269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB bind GPCRs (Canis familiaris)
REACT:R-HSA-5211400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anthrax lef cleaves target cell MAP2K3 (MEK3) (Homo sapiens)
RHEA:36346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 <=> 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)
REACT:R-RNO-265296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Rattus norvegicus)
REACT:R-XTR-2327733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 binds Collagen types I-V, VII (Xenopus tropicalis)
REACT:R-DRE-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Danio rerio)
RHEA:52103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)
REACT:R-SSC-5610737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH bind and ubiquitnate GLI1 (Sus scrofa)
REACT:R-BTA-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Bos taurus)
RHEA:61714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine
REACT:R-CFA-9677917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA inhibitors bind MAOA:FAD (Canis familiaris)
REACT:R-SCE-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)
RHEA:48716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O
RHEA:45155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(methylsulfanyl)propanoyl-CoA <=> 3-oxopropanoyl-CoA + methanethiol
REACT:R-GGA-9691621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5 binds C5 inhibitors (Gallus gallus)
REACT:R-GGA-216727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Gallus gallus)
RHEA:65012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-AMP + holo-[ACP] = AMP + decanoyl-[ACP] + H(+)
RHEA:65904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine
RHEA:14333	skos:altLabel	"GPI-specific phospholipase C"
RHEA:14333	skos:altLabel	"glycosylphosphatidylinositol-specific phospholipase C"
RHEA:14333	skos:altLabel	"glycosyl inositol phospholipid anchor-hydrolyzing enzyme"
RHEA:14333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycosylphosphatidylinositol diacylglycerol-lyase"
RHEA:14333	skos:altLabel	"VSG-lipase"
RHEA:14333	skos:prefLabel	"glycosylphosphatidylinositol diacylglycerol-lyase"
RHEA:14333	skos:altLabel	"(glycosyl)phosphatidylinositol-specific phospholipase C"
RHEA:14333	skos:altLabel	"glycosylphosphatidylinositol-phospholipase C"
RHEA:14333	skos:altLabel	"variant-surface-glycoprotein phospholipase C"
RHEA:14333	skos:altLabel	"6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)"
RHEA:14333	skos:altLabel	"GPI-PLC"
RHEA:14333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acetylserine sulfhydrylase activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acetyl-L-serine sulfohydrolase activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	O-acetylserine (thiol)-lyase A activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine synthase activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylserine sulfhydrylase activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acetyl-L-serine sulfhydrylase activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OAS sulfhydrylase activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine synthetase activity
GO:0004124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acetylserine (thiol)-lyase activity
REACT:R-RNO-1236954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides by IRAP in endocytic vesicles (Rattus norvegicus)
REACT:R-HSA-1475422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPS is phosphorylated by cGMP-dependant protein kinase II (Homo sapiens)
RHEA:39852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + glycerol
REACT:R-CFA-3159259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAA:MUT binds AdoCbl (Canis familiaris)
REACT:R-CEL-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Caenorhabditis elegans)
RHEA:42237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:36712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + H2O + O-ureido-D-serine => ADP + CO2 + D-cycloserine + NH4(+) + phosphate
REACT:R-SSC-70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Sus scrofa)
RHEA:16764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorohydroquinone + O2 <=> 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)
GO:0047643	skos:prefLabel	"mannuronan synthase"
GO:0047643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-D-mannuronate:alginate D-mannuronyltransferase activity
GO:0047643	skos:altLabel	"alginate synthase"
GO:0047643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannuronan synthase"
GO:0047643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alginate synthase activity
GO:0047643	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannuronosyl transferase activity
GO:0047643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate = [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)
GO:0047643	skos:altLabel	"mannuronosyl transferase"
REACT:R-RNO-5617816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A  (Rattus norvegicus)
RHEA:49485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate
RHEA:50939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate <=> acetoacetyl-CoA + L-glutamate
REACT:R-XTR-5666169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Xenopus tropicalis)
REACT:R-MMU-9706350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates CBL (Mus musculus)
REACT:R-MMU-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Mus musculus)
RHEA:15060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-[ACP] + H2O <=> (9Z)-octadecenoate + H(+) + holo-[ACP]
REACT:R-XTR-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Xenopus tropicalis)
RHEA:26516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxohexanoate + H(+) => cyclohexan-1,2-dione + H2O
REACT:R-XTR-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Xenopus tropicalis)
RHEA:62195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + peregrinol + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]
GO:1990970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-activation response element binding
GO:1990970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAR binding
GO:0102334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity
REACT:R-SSC-373732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin trans-homophilic interaction (Sus scrofa)
GO:0098625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylselenol reductase activity
GO:0098625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)
REACT:R-HSA-5618085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)
RHEA:50284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate
REACT:R-CEL-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Caenorhabditis elegans)
REACT:R-HSA-2064421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds ZO-2 (TJP2) (Homo sapiens)
RHEA:59620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(4-aminobutanoyl)-L-lysine = 4-aminobutanoate + L-lysine
REACT:R-BTA-6809720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM1:MTMR12 (Bos taurus)
RHEA:34238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitro-6-oxohepta-2,4-dienedioate <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite
REACT:R-HSA-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)
RHEA:44064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + octan-1-ol = CoA + octyl hexadecanoyl
RHEA:40082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:49526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2
REACT:R-GGA-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Gallus gallus)
RHEA:11406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galacturonate => UDP-alpha-D-glucuronate
REACT:R-XTR-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Xenopus tropicalis)
REACT:R-MMU-420274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIP receptor binds gastric inhibitory peptide (Mus musculus)
RHEA:37000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SSC-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Sus scrofa)
RHEA:71122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hispidin + NADPH + O2 <=> 3-hydroxyhispidin + H2O + NADP(+)
RHEA:61141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + myricetin + succinate
RHEA:10169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-DRE-8848314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36:IL1RL2 binds IL1RAP-1 (Danio rerio)
GO:0004150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroneopterin aldolase activity
GO:0004150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity
GO:0004150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)
REACT:R-HSA-442387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP8 mediates zinc influx into cells (Homo sapiens)
REACT:R-SSC-8956140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 and UBD bind NUB1 and the 26S proteasome (Sus scrofa)
RHEA:41893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H2O
RHEA:31322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + UDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP
RHEA:38315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate = 3-hydroxybenzoate + pyruvate
RHEA:38315	skos:prefLabel	"3-hydroxybenzoate synthase"
RHEA:38315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybenzoate synthase"
RHEA:38315	skos:altLabel	"chorismatase/3-hydroxybenzoate synthase"
RHEA:20967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
REACT:R-MMU-5432814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR2:TLR1 (Mus musculus)
GO:0051073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalamin-5'-phosphate synthase activity
GO:0051073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalamin (5'-phosphate) synthase activity
GO:0051073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobS
GO:0051073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcobinamide-GDP ribazoletransferase activity
GO:0051073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity
GO:0051073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalamin synthase activity
REACT:R-DDI-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
REACT:R-SPO-198609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates TSC2, inhibiting it (Schizosaccharomyces pombe)
REACT:R-MMU-5654167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds PLCG1 (Mus musculus)
RHEA:20049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
RHEA:20049	skos:prefLabel	"phosphoribosyl-AMP cyclohydrolase"
RHEA:20049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosyl-AMP cyclohydrolase"
REACT:R-SCE-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Saccharomyces cerevisiae)
RHEA:52681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-alpha-phenylglycine => CoA + H(+) + N-acetyl-L-alpha-phenylglycine
REACT:R-XTR-210300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and TREM2 (Xenopus tropicalis)
RHEA:29693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + alpha-maltotriose => alpha-maltotetraose + phosphate
REACT:R-HSA-2327695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)
REACT:R-MMU-5617143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Mus musculus)
REACT:R-BTA-9709883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB scavenges O2.- (Bos taurus)
RHEA:34778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) <=> a 3-oxosteroid + CO2 + NADH
GO:0030776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity
GO:0030776	skos:prefLabel	"(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase"
GO:0030776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
GO:0030776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	norreticuline N-methyltransferase activity
GO:0030776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
GO:0030776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase"
GO:0030776	skos:altLabel	"(RS)-tetrahydrobenzylisoquinoline N-methyltransferase"
GO:0030776	skos:altLabel	"norreticuline N-methyltransferase"
GO:0030776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine = H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine
GO:0033408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCG codon-amino acid adaptor activity
GO:0033408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine tRNA
GO:0033408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCG codon-amino acid adaptor activity
REACT:R-HSA-5212679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3A binds Me2sR4-HIST1H4 (Homo sapiens)
REACT:R-HSA-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Homo sapiens)
REACT:R-DRE-2534248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP2, MMP3, MMP7 (Danio rerio)
RHEA:66930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O
REACT:R-BTA-921155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from the receptor complex (Bos taurus)
REACT:R-MMU-8849638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the SPINK5:KLK5 complex at low pH (Mus musculus)
REACT:R-CFA-192042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Canis familiaris)
REACT:R-RNO-8865237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD6 methylates RELA in the NFkB complex (Rattus norvegicus)
RHEA:64292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH = (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)
REACT:R-XTR-9006873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT binding (Xenopus tropicalis)
RHEA:66027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O
REACT:R-DDI-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
REACT:R-SSC-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Sus scrofa)
RHEA:71812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) => 3,3',5-triiodo-L-thyronine(in)
REACT:R-RNO-5205799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Rattus norvegicus)
REACT:R-CFA-199863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate NR4A1 (NUR77) (Canis familiaris)
RHEA:35711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinyl-CoA:acetate CoA-transferase"
RHEA:35711	skos:altLabel	"SCACT"
RHEA:35711	skos:prefLabel	"succinyl-CoA:acetate CoA-transferase"
RHEA:35711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + succinyl-CoA = acetyl-CoA + succinate
REACT:R-HSA-9702583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crenolanib-resistant FLT3 mutants don't bind crenolanib (Homo sapiens)
EC:4.2.3.56	skos:prefLabel	"gamma-humulene synthase"
EC:4.2.3.56	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-humulene synthase"
RHEA:56551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
REACT:R-SSC-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Sus scrofa)
RHEA:71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + succinate = formate + succinyl-CoA
REACT:R-DRE-9646348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Danio rerio)
RHEA:67893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine => 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-XTR-5623519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP and RAB8A bind to the ciliary targeting complex (Xenopus tropicalis)
REACT:R-XTR-9690449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 bind S1P (Xenopus tropicalis)
REACT:R-BTA-3965447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein subunits dissociate from WNT:FZD complex (Bos taurus)
RHEA:65573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9714691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds ER effectors (Homo sapiens)
REACT:R-GGA-9028730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FRS2 (Gallus gallus)
RHEA:29784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-cysteine(in) => ADP + H(+) + L-cysteine(out) + phosphate
GO:0043404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRF receptor activity
GO:0043404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin-releasing factor receptor activity
GO:0043404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRH receptor activity
GO:0043404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenocorticotropin-releasing hormone receptor activity
GO:0043404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin-releasing hormone receptor activity
RHEA:25079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-isopropyl-3-oxosuccinate + H(+) => 4-methyl-2-oxopentanoate + CO2
RHEA:24697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + NADP(+) + trans-isoeugenol <=> (E)-coniferyl acetate + NADPH
RHEA:37592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA => 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-BTA-265426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Tenascin (Bos taurus)
REACT:R-CFA-6797803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds SLITRK1-6 (Canis familiaris)
RHEA:64963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + H2O <=> dTMP + H(+) + phosphate
RHEA:57032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O = CO2 + formate + methylamine + succinate semialdehyde
REACT:R-CFA-420123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like receptor 2 binds GLP2 (Canis familiaris)
RHEA:72886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-phenylpyruvate + 2 ATP <=> 2 AMP + 2 diphosphate + H(+) + polyporic acid
REACT:R-SSC-4085029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU2 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)
RHEA:20940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)
REACT:R-DRE-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Danio rerio)
REACT:R-MMU-2022411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)
REACT:R-DRE-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Danio rerio)
REACT:R-CEL-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Caenorhabditis elegans)
RHEA:64081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]
REACT:R-DRE-8848596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds PXN (Danio rerio)
REACT:R-MMU-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Mus musculus)
REACT:R-PFA-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Plasmodium falciparum)
RHEA:56991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:22530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose
REACT:R-DDI-197268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)
RHEA:70662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N,N-dimethylglycine(in) <=> H(+)(out) + N,N-dimethylglycine(out)
RHEA:13852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose <=> D-ribulose
REACT:R-DME-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Drosophila melanogaster)
RHEA:22214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-tartrate => (2R,3R)-tartrate
REACT:R-RNO-5607757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TRAF6 ubiquitinates TAK1 (Rattus norvegicus)
RHEA:42239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-BTA-193641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKK-beta is recruited (Bos taurus)
RHEA:38145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 H(+) + 2 hydrogen sulfide => carbon disulfide + 2 H2O
REACT:R-RNO-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Rattus norvegicus)
REACT:R-PFA-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Plasmodium falciparum)
REACT:R-DME-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Drosophila melanogaster)
RHEA:49028	skos:prefLabel	"bursehernin 5'-monooxygenase"
RHEA:49028	skos:altLabel	"CYP71CU1"
RHEA:49028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bursehernin 5'-monooxygenase"
RHEA:49028	skos:altLabel	"bursehernin 5'-hydroxylase"
RHEA:49028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8950778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dimerizes (Homo sapiens)
RHEA:38301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA
REACT:R-DDI-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
EC:3.1.1.111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylserine sn-1 acylhydrolase"
EC:3.1.1.111	skos:altLabel	"phosphatidylserine-specific phospholipase A1"
EC:3.1.1.111	skos:prefLabel	"phosphatidylserine sn-1 acylhydrolase"
REACT:R-RNO-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Rattus norvegicus)
REACT:R-RNO-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)
RHEA:34149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-scyllo-inosamine + 2-oxoglutaramate => 2-deoxy-L-scyllo-inosose + L-glutamine
RHEA:61695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP <=> AMP + L-threonyl-[peptidyl-carrier protein]
RHEA:28274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-S-adenosyl-L-methionine = (R)-S-adenosyl-L-methionine
REACT:R-XTR-9612501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates CREB1 (Xenopus tropicalis)
REACT:R-RNO-9708430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 (CRM1) binds to BACH1:Hemes (Rattus norvegicus)
REACT:R-HSA-8848339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA5 hydrolyzes TAG (Homo sapiens)
RHEA:62497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-arginine => diphosphate + L-arginyl-AMP
REACT:R-SSC-5604929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C binds Protein S (Sus scrofa)
GO:0001139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II complex recruiting activity
GO:0001139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	core RNA polymerase II recruiting transcription factor activity
GO:0001139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription factor activity, core RNA polymerase II recruiting
REACT:R-SSC-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Sus scrofa)
REACT:R-SSC-73945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAS-mediated dimerization of procaspase-8 (Sus scrofa)
REACT:R-BTA-451283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kainate receptor binds glutamate (Bos taurus)
REACT:R-HSA-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Homo sapiens)
RHEA:43618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)
REACT:R-CFA-8874083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y397-PTK2 binds SRC (Canis familiaris)
REACT:R-DME-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)
REACT:R-MMU-5607723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Mus musculus)
RHEA:50388	skos:prefLabel	"12-dehydrotetracycline 5-monooxygenase"
RHEA:50388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"12-dehydrotetracycline 5-monooxygenase"
RHEA:50388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5a,11a-dehydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrooxytetracycline + H2O + NADP(+)
REACT:R-SCE-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Saccharomyces cerevisiae)
RHEA:63768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine
RHEA:13928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine
REACT:R-XTR-9758090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Xenopus tropicalis)
REACT:R-XTR-428007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled histidine and di-peptide cotransport (Xenopus tropicalis)
RHEA:67586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine
RHEA:68009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate
RHEA:62295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2
RHEA:38399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)
REACT:R-SSC-2395784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent CMs transform into mature CMs (Sus scrofa)
RHEA:44843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + octadecanoyl-CoA <=> CoA + O-octadecanoyl-(R)-carnitine
REACT:R-SCE-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Saccharomyces cerevisiae)
RHEA:60912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine
RHEA:19634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) => (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)
REACT:R-SSC-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Sus scrofa)
RHEA:57242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-(1-hydroxy-2-oxoethyl)-GMP => glyoxal + GMP
RHEA:23313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 sucrose => 1(F)-beta-D-fructosylsucrose + D-glucose
RHEA:59826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate
RHEA:36098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + salicylate <=> methyl salicylate + S-adenosyl-L-homocysteine
RHEA:60961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP
REACT:R-SSC-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Sus scrofa)
RHEA:45459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoylethanolamine <=> dodecanoate + ethanolamine
REACT:R-DRE-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Danio rerio)
REACT:R-GGA-9014467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the ER membrane (Gallus gallus)
RHEA:40983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)
RHEA:54505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-hexaprenyl diphosphate => beta-hexaprene + diphosphate
RHEA:58169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-5-epi-eremophilene + diphosphate
REACT:R-DRE-983703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-SYK phosphorylates BLNK (SLP65) (Danio rerio)
REACT:R-GGA-1250346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Gallus gallus)
RHEA:42129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine
REACT:R-SCE-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Saccharomyces cerevisiae)
RHEA:53945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) => (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH
REACT:R-SPO-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Schizosaccharomyces pombe)
REACT:R-CEL-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Caenorhabditis elegans)
REACT:R-XTR-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)
RHEA:21262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + L-methionine (R)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine
GO:0033720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity
GO:0033720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MDH
GO:0033720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-mandelate dehydrogenase activity
GO:0033720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L(+)-mandelate dehydrogenase activity
GO:0097365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stretch-activated, cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential
REACT:R-XTR-9648089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6 and NEK7 phosphorylate EML4 (Xenopus tropicalis)
REACT:R-BTA-1973968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 4A and 103 bind CCR2 (Bos taurus)
RHEA:37926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate
REACT:R-BTA-8874078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Bos taurus)
RHEA:52818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine
RHEA:14879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + L-glutamyl 5-phosphate => ATP + L-glutamate
REACT:R-DME-1470012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus (Drosophila melanogaster)
RHEA:62857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-HSA-6798373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates DYRK2 (Homo sapiens)
RHEA:19967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylate + dimethyl sulfide + H(+) => S,S-dimethyl-beta-propiothetin
REACT:R-XTR-8875523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS3 (Xenopus tropicalis)
RHEA:52338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-AMP + diphosphate => a long-chain fatty acid + ATP + H(+)
REACT:R-XTR-390598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Xenopus tropicalis)
REACT:R-XTR-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Xenopus tropicalis)
RHEA:23113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylsalicylate + H(+) => 3-methylphenol + CO2
REACT:R-MMU-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Mus musculus)
REACT:R-MMU-5654406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Mus musculus)
REACT:R-RNO-420598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:Nectin-4 trans heterodimer formation (Rattus norvegicus)
RHEA:43111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + N2 <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide
RHEA:71013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(out) + L-phenylalanine(in) => L-isoleucine(in) + L-phenylalanine(out)
GO:0031516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	far-red light photoreceptor activity
RHEA:60259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + L-lysyl(4)-[histone H3]
RHEA:14458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + pentanoyl-CoA => 3-propylmalate + CoA + H(+)
REACT:R-SSC-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Sus scrofa)
REACT:R-CFA-1606288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Canis familiaris)
REACT:R-DME-1980125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH binds DTX (Drosophila melanogaster)
GO:0050431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta ligand binding to type II receptor
GO:0050431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor beta binding
GO:0050431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta ligand binding to type I receptor
GO:0050431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFbeta binding
GO:0050431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGF-beta binding
RHEA:19256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin + H2O <=> an N-acylsphing-4-enine + H(+) + phosphocholine
GO:0004788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin diphosphokinase activity
GO:0004788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:thiamin pyrophosphotransferase activity
GO:0004788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPTase activity
GO:0004788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin pyrophosphotransferase activity
GO:0004788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiaminokinase activity
GO:0004788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine diphosphokinase activity
GO:0004788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:thiamine diphosphotransferase activity
GO:0004788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin pyrophosphokinase activity
GO:0004788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine pyrophosphokinase activity
GO:0004788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin:ATP pyrophosphotransferase activity
RHEA:52765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate
REACT:R-RNO-9605600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Rattus norvegicus)
RHEA:14068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inosose <=> 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O
REACT:R-DME-5689544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds INO80 complex (Drosophila melanogaster)
REACT:R-HSA-8849085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RHOA:GTP (Homo sapiens)
REACT:R-HSA-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Homo sapiens)
REACT:R-SCE-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Saccharomyces cerevisiae)
REACT:R-DRE-8987033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Danio rerio)
RHEA:59403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-aminohexanoate <=> D-2-aminohexanoate
GO:0033839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol-3-O-glycoside glucosyltransferase activity
GO:0033839	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity
GO:0033839	skos:prefLabel	"flavonol-3-O-glycoside glucosyltransferase"
GO:0033839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonol-3-O-glycoside glucosyltransferase"
GO:0033839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP
RHEA:50163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine
REACT:R-GGA-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Gallus gallus)
REACT:R-HSA-9627104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP3 (Homo sapiens)
RHEA:68368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP
REACT:R-PFA-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Plasmodium falciparum)
REACT:R-DME-6804402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F1 (Drosophila melanogaster)
RHEA:17023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + phosphonoacetaldehyde => (2-aminoethyl)phosphonate + pyruvate
RHEA:60470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)
RHEA:40574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-MMU-3640861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 ubiquitinates ADP-ribosylated AXIN (Mus musculus)
RHEA:40315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2
REACT:R-GGA-9690449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 bind S1P (Gallus gallus)
REACT:R-CFA-5651654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)
REACT:R-CEL-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Caenorhabditis elegans)
RHEA:41803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:22008	skos:altLabel	"homoserine O-transsuccinylase"
RHEA:22008	skos:prefLabel	"homoserine O-succinyltransferase"
RHEA:22008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homoserine O-succinyltransferase"
RHEA:22008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine
RHEA:52470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate
RHEA:20987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin + H2O <=> an N-acylsphing-4-enine 1-phosphate + choline + H(+)
RHEA:29029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + L-glutamate(out) => 2 H(+)(in) + L-glutamate(in)
RHEA:41572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH
GO:0004615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphomannomutase activity
GO:0004615	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannose phosphomutase activity
GO:0004615	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannose 1,6-phosphomutase activity
GO:0004615	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphomannose mutase activity
GO:0004615	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-mannose 1,6-phosphomutase activity
REACT:R-RNO-5683588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 transfers ATG12 from ATG10 to ATG5 (Rattus norvegicus)
RHEA:65322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin A + CO2 + succinate => 2-oxoglutarate + chrodrimanin E + O2
RHEA:35791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine = H(+) + kanamycin X + UDP
REACT:R-SSC-8983983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Sus scrofa)
REACT:R-MMU-6799431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds HIPK1 (Mus musculus)
REACT:R-GGA-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Gallus gallus)
REACT:R-RNO-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Rattus norvegicus)
REACT:R-DME-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Drosophila melanogaster)
REACT:R-BTA-5423678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)
REACT:R-XTR-1482695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Xenopus tropicalis)
REACT:R-CEL-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Caenorhabditis elegans)
RHEA:41773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) => CMP + ganglioside GQ1b (d18:1(4E)) + H(+)
REACT:R-MMU-9624120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK2 (Mus musculus)
REACT:R-XTR-6791235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds AURKA (Xenopus tropicalis)
GO:0050572	skos:altLabel	"L-idonate 5-dehydrogenase"
GO:0050572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-idonate 5-dehydrogenase (NAD(+))"
GO:0050572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate 5-dehydrogenase activity
GO:0050572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH
GO:0050572	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-idonate:NAD(P)+ oxidoreductase activity
GO:0050572	skos:prefLabel	"L-idonate 5-dehydrogenase (NAD(+))"
GO:0050572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-idonate 5-dehydrogenase [NAD(P)(+)]"
GO:0050572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH
GO:0050572	skos:prefLabel	"L-idonate 5-dehydrogenase [NAD(P)(+)]"
REACT:R-MMU-205075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JNK phosphorylates BIM, BAD and other targets (Mus musculus)
RHEA:69003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine <=> 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine
RHEA:72494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + maleate(in) <=> citrate(in) + maleate(out)
REACT:R-MMU-6814094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds ARFIP2 (Mus musculus)
REACT:R-HSA-8955712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer (Homo sapiens)
REACT:R-MMU-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Mus musculus)
REACT:R-RNO-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Rattus norvegicus)
RHEA:48462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O
RHEA:72334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
REACT:R-CFA-5610754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Canis familiaris)
REACT:R-MMU-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Mus musculus)
RHEA:65912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + pyruvate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine
REACT:R-XTR-5626962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB2L1 binds IKKA:IKKB:NEMO (Xenopus tropicalis)
RHEA:58262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + L-tyrosyl-[protein] => H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]
REACT:R-SSC-177671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Sus scrofa)
REACT:R-BTA-211874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2S1 4-hydroxylates atRA (Bos taurus)
REACT:R-XTR-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Xenopus tropicalis)
REACT:R-SCE-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Saccharomyces cerevisiae)
RHEA:48829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NADP(+)
REACT:R-CEL-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Caenorhabditis elegans)
RHEA:44406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + ubiquinol-7 => 3-demethylubiquinol-7 + S-adenosyl-L-methionine
REACT:R-GGA-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Gallus gallus)
REACT:R-HSA-167459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive  termination of HIV-1 elongation after arrest (Tat-containing elongation complex) (Homo sapiens)
REACT:R-GGA-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Gallus gallus)
RHEA:35578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-3215385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Danio rerio)
RHEA:28708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(in) => Cd(2+)(out)
RHEA:36906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine
REACT:R-CEL-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Caenorhabditis elegans)
REACT:R-SSC-9759169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Sus scrofa)
REACT:R-CFA-5323545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canonical WNT signaling through the atypical receptor RYK (Canis familiaris)
REACT:R-HSA-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Homo sapiens)
GO:0050329	skos:prefLabel	"tetrahydroxypteridine cycloisomerase"
GO:0050329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrahydroxypteridine cycloisomerase"
GO:0050329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pteridine-2,4,6,7-tetrol = H(+) + xanthine-8-carboxylate
GO:0050329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydroxypteridine lyase (isomerizing)
GO:0050329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydroxypteridine cycloisomerase activity
GO:0090434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleoyl-CoA ligase activity
GO:0090434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleoyl-CoA synthetase activity
REACT:R-CFA-8863472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAB2 binds LRP2 (Canis familiaris)
REACT:R-GGA-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Gallus gallus)
RHEA:18744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA <=> 10-deacetylbaccatin III + CoA
RHEA:29474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + H2O <=> D-ribose + phosphate
REACT:R-DME-8867044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)
REACT:R-MMU-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Mus musculus)
REACT:R-DRE-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Danio rerio)
GO:0102944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	medicagenate UDP-glucosyltransferase activity
RHEA:37915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-MMU-391940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 and EP4 receptors can bind PGE2 (Mus musculus)
RHEA:51532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + urate = 5-hydroxyisourate + H2O + NADP(+)
REACT:R-XTR-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Xenopus tropicalis)
RHEA:46524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-9704248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM4 binds CHRM4 antagonists (Danio rerio)
RHEA:50631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-(omega-methylsulfanyl)alkylmalate <=> a 3-(omega-methylsulfanyl)alkylmalate
RHEA:30829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
REACT:R-RNO-443978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR11 binds CCL19, CCL21 & CCL25 (Rattus norvegicus)
REACT:R-SSC-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Sus scrofa)
REACT:R-BTA-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Bos taurus)
REACT:R-CFA-352103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Canis familiaris)
RHEA:64495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] <=> dehydrocitreoisocoumarin + H2O + holo-[ACP]
REACT:R-HSA-349626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha2beta1 binds laminin-332 (Homo sapiens)
REACT:R-DRE-349657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)
RHEA:10646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H2O
REACT:R-CFA-193401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
REACT:R-RNO-8964284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in active Gq-BTK complex is activated (Rattus norvegicus)
RHEA:15179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O
RHEA:31164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O
REACT:R-DRE-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Danio rerio)
REACT:R-DME-1168640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated IkB is degraded (Drosophila melanogaster)
REACT:R-XTR-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Xenopus tropicalis)
REACT:R-CFA-179467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Canis familiaris)
RHEA:33009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:50802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin A2-S-(S)-glutathione => glutathione + prostaglandin A2
REACT:R-RNO-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Rattus norvegicus)
REACT:R-RNO-5324632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Rattus norvegicus)
RHEA:42013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + NAD(+) => 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH
RHEA:47491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isodeoxycholate + NADP(+)
RHEA:23247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermidine + S-methyl-5'-thioadenosine
REACT:R-CEL-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Caenorhabditis elegans)
REACT:R-DME-8948800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNKS and TNKS2 PARylate PTEN (Drosophila melanogaster)
REACT:R-HSA-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Homo sapiens)
REACT:R-HSA-3371385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α is cleaved by ADAM17 (TACE) (Homo sapiens)
REACT:R-DRE-5649708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 recruits POLB to incised AP site (Danio rerio)
REACT:R-HSA-9684234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)
RHEA:28933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxy-2-hydroxy-cis,cis-muconate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
REACT:R-BTA-2395328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP1, LTBP3 bind TGF-Beta (Bos taurus)
RHEA:13103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trans-urocanate => 4-imidazolone-5-propanoate
RHEA:45931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-DDI-9020610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Dictyostelium discoideum)
REACT:R-RNO-977375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR1 binds C3bBb/C4bC2a (Rattus norvegicus)
REACT:R-RNO-198513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Rattus norvegicus)
REACT:R-DRE-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Danio rerio)
REACT:R-HSA-4420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 disassociates from VEGFR2 and translocate to PM (Homo sapiens)
REACT:R-DRE-75238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL binds TRAIL receptors (Danio rerio)
REACT:R-RNO-2130151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of DAP12 (Rattus norvegicus)
RHEA:39065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + scyllo-inosose => NADP(+) + scyllo-inositol
RHEA:29226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-8 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + menaquinol-8
REACT:R-GGA-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Gallus gallus)
REACT:R-HSA-2730599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT3 Dimer Translocates to the Nucleus (Homo sapiens)
REACT:R-MMU-2022381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)
RHEA:43524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine + NADP(+) = aminoacetone + CO2 + NADPH
RHEA:43524	skos:prefLabel	"3-hydroxy acid dehydrogenase"
RHEA:43524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy acid dehydrogenase"
REACT:R-RNO-379387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DA to form 3MT (Rattus norvegicus)
REACT:R-SSC-109538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Sus scrofa)
RHEA:19998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphoenolpyruvate => phosphate + pyruvate
REACT:R-HSA-175250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Suicidal integration leading to smaller circles of viral DNA (Homo sapiens)
RHEA:32530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose + phosphate <=> N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine
RHEA:21318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate + H(+) + phorbol 13-butanoate => H2O + phorbol 12,13-dibutanoate
REACT:R-HSA-380508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NuMA to the centrosomes (Homo sapiens)
REACT:R-MMU-8875374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds LRIG1 (Mus musculus)
REACT:R-MMU-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Mus musculus)
RHEA:57037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->6)-alpha-D-glucosyl](n) + sucrose => (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose
GO:0034782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylmalonate decarboxylase activity
RHEA:51128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + an aliphatic amine + H2O = AH2 + an aldehyde + NH4(+)
REACT:R-DRE-8851954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GAB1 recruits PI3K to MET (Danio rerio)
REACT:R-DRE-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)
GO:0008331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-type calcium channel
GO:0008331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high voltage-dependent calcium channel activity
GO:0008331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high voltage gated calcium channel activity
GO:0008331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Q-type calcium channel
GO:0008331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-type calcium channel
GO:0008331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P-type calcium channel
GO:0008331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high voltage-gated calcium channel activity
REACT:R-DDI-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Dictyostelium discoideum)
REACT:R-GGA-2029455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIA with IgG-coated Ag (Gallus gallus)
REACT:R-HSA-349426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MDM4 by CHEK2 (Homo sapiens)
REACT:R-BTA-8944263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type II (Bos taurus)
REACT:R-CFA-983145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Canis familiaris)
REACT:R-BTA-2473584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP15 (Bos taurus)
REACT:R-DRE-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Danio rerio)
REACT:R-RNO-5625745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 stimulates association of AR with NCOA2 (Rattus norvegicus)
REACT:R-HSA-8853789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDNF,NRTN bind RET:GFRA1,GFRA2 (Homo sapiens)
RHEA:45712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnityl-CoA + CoA = acetyl-CoA + N,N,N-trimethylglycyl-CoA
REACT:R-SSC-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Sus scrofa)
REACT:R-HSA-8964605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Homo sapiens)
REACT:R-BTA-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Bos taurus)
REACT:R-DRE-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Danio rerio)
RHEA:70757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine
REACT:R-DRE-909732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT2 (Danio rerio)
REACT:R-MMU-2309779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer binds PTGS2 inhibitors (Mus musculus)
REACT:R-DRE-5675206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEA15 binds MAPK monomers and dimers (Danio rerio)
REACT:R-SSC-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Sus scrofa)
REACT:R-DDI-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Dictyostelium discoideum)
GO:2001073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclodextrin binding
REACT:R-CFA-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
GO:0031132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine:NADP+ 3-oxidoreductase activity
GO:0031132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine 3-dehydrogenase activity
REACT:R-RNO-5693578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDP1 and TDP2 process unligatable DSB ends (Rattus norvegicus)
RHEA:30021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + lipid A-core => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A
RHEA:67038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2
RHEA:31365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n) => NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n)
GO:0050781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ortho-trichlorophenol reductive dehalogenase activity
GO:0050781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-TCP reductive dehalogenase activity
GO:0050781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trichlorophenol reductive dehalogenase activity
RHEA:52679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine
REACT:R-XTR-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Xenopus tropicalis)
REACT:R-HSA-9769115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1,(MAPK3) phosphorylates NPAS4 (Homo sapiens)
RHEA:28871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructuronate(in) + H(+)(in) = D-fructuronate(out) + H(+)(out)
GO:0000100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methylmethionine transmembrane transporter activity
GO:0000100	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	S-methylmethionine transporter activity
GO:0000100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methylmethionine permease activity
REACT:R-HSA-428990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonate diffuses across the ER membrane (Homo sapiens)
REACT:R-RNO-5655142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 binds POLH (Rattus norvegicus)
RHEA:20514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aryl-2-methylmalonate + H(+) => 2-arylpropionate + CO2
RHEA:53240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine
REACT:R-SSC-2424481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)
RHEA:51009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome cL] + methanol => 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)
RHEA:45897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + CDP-ethanolamine => an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)
REACT:R-HSA-8938356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RMB14 binds RUNX2 (Homo sapiens)
RHEA:40150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + H2O <=> CoA + eicosanoate + H(+)
RHEA:33623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA
REACT:R-XTR-5693620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop formation mediated by PALB2, BRCA2 and RAD51 (Xenopus tropicalis)
REACT:R-RNO-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Rattus norvegicus)
REACT:R-MMU-74993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Mus musculus)
REACT:R-PFA-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Plasmodium falciparum)
RHEA:68450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal => 13-cis-lycopene + O2
REACT:R-BTA-9705713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 dehydrogenates TEST to DHTEST (Bos taurus)
REACT:R-DRE-2031355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)
GO:0033767	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HAPMO
GO:0033767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity
GO:0033767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyacetophenone monooxygenase activity
REACT:R-MMU-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Mus musculus)
REACT:R-GGA-1592387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin binds elastic fibres (Gallus gallus)
REACT:R-CEL-8869603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A13 transports NCA from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-MMU-114256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS:APAF1 binds procaspase-9 (Mus musculus)
REACT:R-MMU-9020262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Mus musculus)
GO:0005502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis retinal binding
GO:0005502	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	11-cis-retinal binding
GO:0005502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis retinaldehyde binding
GO:0005502	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	vitamin A binding
REACT:R-SSC-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Sus scrofa)
RHEA:43202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine
GO:0045309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoprotein amino acid binding
GO:0045309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphorylated amino acid binding
RHEA:49316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-6785165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Danio rerio)
REACT:R-BTA-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Bos taurus)
REACT:R-RNO-139918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BIM by JNK (Rattus norvegicus)
GO:0086089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization
GO:0086089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
RHEA:40915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-HSA-2632521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Homo sapiens)
REACT:R-CFA-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Canis familiaris)
REACT:R-DME-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Drosophila melanogaster)
REACT:R-DRE-140783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Danio rerio)
REACT:R-DRE-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Danio rerio)
REACT:R-RNO-9649963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC3 channel blockers bind ASIC3 trimer (Rattus norvegicus)
REACT:R-HSA-8870710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APP gene expression (Homo sapiens)
GO:0015123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate transmembrane transporter activity
REACT:R-BTA-4754181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me2K5-histone H3 (Bos taurus)
REACT:R-XTR-114254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS binds to APAF1 (Xenopus tropicalis)
REACT:R-DDI-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Dictyostelium discoideum)
REACT:R-HSA-937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
REACT:R-BTA-5225602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR5 binds Me2sR3-replicative histone H3 (Bos taurus)
GO:0004452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyl-diphosphate delta-isomerase activity
GO:0004452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyl-diphosphate D-isomerase activity
GO:0004452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopentenylpyrophosphate isomerase activity
GO:0004452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopentenyl-diphosphate delta3-delta2-isomerase activity
GO:0004452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IPP isomerase activity
GO:0004452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopentenylpyrophosphate delta-isomerase activity
GO:0004452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylbutenylpyrophosphate isomerase activity
RHEA:47936	skos:prefLabel	"4-hydroxybenzaldehyde dehydrogenase (NADP(+))"
RHEA:47936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzaldehyde dehydrogenase (NADP(+))"
RHEA:47936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + H2O + NADP(+) = 4-hydroxybenzoate + 2 H(+) + NADPH
RHEA:47936	skos:altLabel	"p-hydroxybenzaldehyde dehydrogenase"
REACT:R-BTA-8953917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Bos taurus)
REACT:R-SSC-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Sus scrofa)
REACT:R-DDI-8875071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSS3 ligates CoA to CH3COO- (Dictyostelium discoideum)
REACT:R-MMU-202500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of IKK complex (Mus musculus)
RHEA:53209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:22974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H(+) + NADPH => butanal + CoA + NADP(+)
RHEA:11177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kojibiose + phosphate => beta-D-glucose 1-phosphate + D-glucose
REACT:R-GGA-5685649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPAs translocate from ER membrane to extracellular region (Gallus gallus)
REACT:R-XTR-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Xenopus tropicalis)
RHEA:41024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA
REACT:R-GGA-5651654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)
REACT:R-CEL-6808496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
REACT:R-HSA-5610741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI1 (Homo sapiens)
REACT:R-MMU-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Mus musculus)
REACT:R-CFA-9686524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6-PPP6R3 dephosphorylates TERF2 (Canis familiaris)
REACT:R-GGA-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Gallus gallus)
RHEA:19803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + diphosphate => (R)-4'-phosphopantetheine + ATP + H(+)
RHEA:25582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-fucose => alpha-L-fucose
REACT:R-BTA-9648089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6 and NEK7 phosphorylate EML4 (Bos taurus)
RHEA:59604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermidine = H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)
RHEA:69145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O + O2 => 4-guanidinobutanal + H2O2 + NH4(+)
REACT:R-HSA-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Homo sapiens)
EC:2.4.1.168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xyloglucan 4-glucosyltransferase"
EC:2.4.1.168	skos:prefLabel	"xyloglucan 4-glucosyltransferase"
RHEA:22331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) <=> diphosphate + thiamine phosphate
RHEA:71436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic L-alpha-amino acid(in) + L-thyroxine(out) => an aromatic L-alpha-amino acid(out) + L-thyroxine(in)
GO:0016500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-hormone receptor activity
RHEA:48827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + Lc4Cer <=> a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)
REACT:R-SSC-1433428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2 is indirectly recruited to p-KIT through SHP2 (Sus scrofa)
GO:0050351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inorganic trimetaphosphatase activity
GO:0050351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimetaphosphatase activity
GO:0050351	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimetaphosphate hydrolase activity
REACT:R-PFA-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Plasmodium falciparum)
REACT:R-DRE-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Danio rerio)
REACT:R-XTR-4420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 disassociates from VEGFR2 and translocate to PM (Xenopus tropicalis)
REACT:R-DRE-5671970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CIT binds KIF14 and PRC1 (Danio rerio)
RHEA:28150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + spermidine = CoA + H(+) + N(1)-acetylspermidine
RHEA:51287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate
REACT:R-HSA-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Homo sapiens)
REACT:R-HSA-1989751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FABP1 (Homo sapiens)
RHEA:15184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA(out) + ATP + H2O <=> ADP + an acyl-CoA(in) + H(+) + phosphate
RHEA:67446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + formyl-CoA => an (R)-2-hydroxy-long-chain-fatty acyl-CoA
REACT:R-MMU-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Mus musculus)
RHEA:17728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2-methylcitrate <=> 2-methyl-cis-aconitate + H2O
REACT:R-MMU-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Mus musculus)
REACT:R-DME-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Drosophila melanogaster)
RHEA:34583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + pentalenolactone D = CO2 + H2O + pentalenolactone E + succinate
RHEA:62025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesteryl 3-beta-D-glucoside + H2O => campesterol + D-glucose
RHEA:57494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA
REACT:R-CFA-2076220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
REACT:R-DME-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Drosophila melanogaster)
REACT:R-HSA-5661120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Homo sapiens)
RHEA:66623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-420214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The adrenomedullin receptor can bind adrenomedullin and intermedin (Homo sapiens)
REACT:R-RNO-508369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Rattus norvegicus)
REACT:R-SSC-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Sus scrofa)
RHEA:38356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + H2O
REACT:R-XTR-8858298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRASLS transfer acyl group from PC to PE to form NAPE (Xenopus tropicalis)
RHEA:41028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA
REACT:R-DDI-8847638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Dictyostelium discoideum)
REACT:R-RNO-2168886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemopexin binds Hemes (Rattus norvegicus)
RHEA:51079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SSC-5668605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2:GTP binds NOX2 complex (Sus scrofa)
REACT:R-XTR-429571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Xenopus tropicalis)
REACT:R-MMU-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Mus musculus)
REACT:R-HSA-9606159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK autophosphorylates (Homo sapiens)
REACT:R-HSA-8869568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM1 binds TFAP2A homodimer (Homo sapiens)
RHEA:29248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+)(out) + 2 Na(+)(in) => 3 H(+)(in) + 2 Na(+)(out)
RHEA:29334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + 2 H(+)(in) <=> fumarate(out) + 2 H(+)(out)
REACT:R-XTR-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Xenopus tropicalis)
REACT:R-MMU-2161282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastic fibres bind associated proteins (Mus musculus)
REACT:R-XTR-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Xenopus tropicalis)
RHEA:68685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) => adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)
REACT:R-BTA-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Bos taurus)
REACT:R-HSA-391939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP receptor can bind thromboxane (Homo sapiens)
EC:3.4.17.11	skos:altLabel	"carboxypeptidase G2"
EC:3.4.17.11	skos:altLabel	"carboxypeptidase G"
EC:3.4.17.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate carboxypeptidase"
EC:3.4.17.11	skos:altLabel	"carboxypeptidase G1"
EC:3.4.17.11	skos:prefLabel	"glutamate carboxypeptidase"
REACT:R-DRE-173680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C5 (Danio rerio)
RHEA:63821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + petrobactin
RHEA:13021	skos:altLabel	"4-hydroxy-3-methoxybenzoate demethylase"
RHEA:13021	skos:altLabel	"vanillate demethylase"
RHEA:13021	skos:prefLabel	"vanillate monooxygenase"
RHEA:13021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vanillate monooxygenase"
RHEA:13021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)
GO:0062184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0062184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone 16-beta-hydroxylase activity
REACT:R-DME-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Drosophila melanogaster)
RHEA:15238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c2] + NADPH => 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)
REACT:R-BTA-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Bos taurus)
REACT:R-HSA-1306969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)
RHEA:57947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + harderoheme III <=> CO2 + 2 H2O + heme b
REACT:R-MMU-9014420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the phagocytic vesicle membrane (Mus musculus)
REACT:R-CFA-445448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHIP binds Hedgehog (Canis familiaris)
REACT:R-HSA-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)
REACT:R-CFA-3322009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Canis familiaris)
REACT:R-CEL-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Caenorhabditis elegans)
RHEA:64423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-proline(out) <=> H(+)(in) + L-alanyl-L-proline(in)
RHEA:57536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate = a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)
REACT:R-BTA-2730892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV to p-SLP-76 (Bos taurus)
RHEA:32024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => avermitilol + diphosphate
REACT:R-DRE-909730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of INFAR1 by TYK2 (Danio rerio)
RHEA:65153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + UDP-alpha-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-HSA-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Homo sapiens)
REACT:R-MMU-1299338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRESK (Mus musculus)
RHEA:36695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = desmethyldescarbamoylnovobiocin + dTDP + H(+)
RHEA:36695	skos:prefLabel	"L-demethylnoviosyl transferase"
RHEA:36695	skos:altLabel	"L-noviosyl transferase"
RHEA:36695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-demethylnoviosyl transferase"
RHEA:69807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-AMP + CoA = AMP + benzoyl-CoA + H(+)
RHEA:13830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
REACT:R-CFA-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
REACT:R-RNO-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)
REACT:R-HSA-194017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 11DCORST to CORST (Homo sapiens)
GO:0034855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-AD 9alpha-hydroxylase activity
REACT:R-DME-110442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated DINR binds Chico (Drosophila melanogaster)
REACT:R-DRE-2197770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1 (FEEL-1) binds ligands (Danio rerio)
REACT:R-RNO-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Rattus norvegicus)
GO:0018682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrazine N-dealkylase activity
GO:0018682	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	atrazine monooxygenase activity
REACT:R-DDI-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
RHEA:47628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + propanoyl-CoA = 3-methylmalate + CoA + H(+)
RHEA:36530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA <=> (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA
REACT:R-GGA-1474197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP1,3,8,13,PRSS2 (Gallus gallus)
RHEA:54112	skos:prefLabel	"selina-4(15),7(11)-diene synthase"
RHEA:54112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"selina-4(15),7(11)-diene synthase"
RHEA:54112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + selina-4(15),7(11)-diene
RHEA:47870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => di-(9Z)-octadecenoylglycerol + H2O
RHEA:63707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolate + UDP-alpha-D-glucuronate <=> H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP
REACT:R-SPO-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Schizosaccharomyces pombe)
REACT:R-DRE-5682629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Danio rerio)
RHEA:27273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanal + NADP(+) <=> H(+) + hexadecanoyl-CoA + NADPH
GO:0047519	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinate:pyrroloquinoline-quinone 5-oxidoreductase activity
GO:0047519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinate:quinone 3-oxidoreductase activity
GO:0047519	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)-independent quinate dehydrogenase activity
GO:0047519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinate dehydrogenase (quinone) activity
RHEA:54433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate
REACT:R-MMU-5357845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is deubiquitinated (Mus musculus)
RHEA:27675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dADP => ADP + dATP
RHEA:32690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> diphosphate + tricyclene
REACT:R-RNO-3828025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP14 (Rattus norvegicus)
GO:0046921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha(1,6)-fucosyltransferase activity
GO:0046921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-(1->6)-fucosyltransferase activity
GO:0046921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-(1,6)-fucosyltransferase activity
GO:0046921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,6-fucosyltransferase activity
REACT:R-MMU-4641253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 ubiquitinates FZD to promote its downregulation (Mus musculus)
REACT:R-RNO-391378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follicle-stimulating hormone receptor can bind FSH (Rattus norvegicus)
RHEA:60690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinate + 2 H(+) + NADH => (11R)-dihydroartemisinic aldehyde + H2O + NAD(+)
RHEA:56100	skos:altLabel	"SAMP-activating enzyme E1"
RHEA:56100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"SAMP-activating enzyme"
RHEA:56100	skos:prefLabel	"SAMP-activating enzyme"
RHEA:56100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) = [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-XTR-8937113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)
REACT:R-DRE-1605724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Danio rerio)
GO:0004456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)
GO:0004456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphogluconate dehydrase activity
GO:0004456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphogluconate dehydratase activity
GO:0004456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gluconate 6-phosphate dehydratase activity
GO:0004456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphogluconate dehydratase activity
GO:0004456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphogluconic dehydrase activity
GO:0004456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-D-gluconate hydro-lyase activity
GO:0004456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gluconate-6-phosphate dehydratase activity
REACT:R-RNO-5362549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np traffics to the plasma membrane (Rattus norvegicus)
REACT:R-RNO-77608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of A1CF to stem-looped RNA (Rattus norvegicus)
EC:1.1.1.282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinate/shikimate dehydrogenase [NAD(P)(+)]"
EC:1.1.1.282	skos:altLabel	"quinate/shikimate dehydrogenase"
EC:1.1.1.282	skos:prefLabel	"quinate/shikimate dehydrogenase [NAD(P)(+)]"
REACT:R-HSA-112155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters (Homo sapiens)
REACT:R-CFA-5357860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Canis familiaris)
RHEA:46187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + isovalerate <=> 3-methylbutanoyl-CoA + AMP + diphosphate
RHEA:30093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + NH4(+) + pyruvate => a ubiquinone + D-alanine + H2O
REACT:R-SCE-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Saccharomyces cerevisiae)
REACT:R-BTA-5683801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates BRCA1 (Bos taurus)
REACT:R-MMU-9638078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from keratan sulfate (Mus musculus)
RHEA:38255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + succinyl-CoA = (S)-malyl-CoA + succinate
REACT:R-BTA-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Bos taurus)
REACT:R-SSC-6788582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 phosphorylation (Sus scrofa)
REACT:R-RNO-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Rattus norvegicus)
REACT:R-XTR-8948224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)
REACT:R-BTA-5694126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)
REACT:R-GGA-8987104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Gallus gallus)
REACT:R-SSC-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Sus scrofa)
RHEA:52463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:54243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:17360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 2 R'C(R)SH <=> H2O2 + R'C(R)S-S(R)CR'
REACT:R-DRE-9018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds interacting proteins at the endosome membrane (Danio rerio)
REACT:R-SSC-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Sus scrofa)
REACT:R-GGA-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Gallus gallus)
REACT:R-RNO-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Rattus norvegicus)
REACT:R-SSC-9731924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds EDNs (Sus scrofa)
RHEA:72108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-acyl-(R)-carnitine(out) => Na(+)(in) + O-acyl-(R)-carnitine(in)
REACT:R-HSA-2408556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeO3(2-) combines with GSH to form GSSeSG and GSSG (Homo sapiens)
GO:0005178	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	integrin ligand
GO:0005178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	integrin binding
REACT:R-HSA-5577244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2 variant:MSH6-defective DNA mismatch repair (Homo sapiens)
REACT:R-DRE-8987039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL20RA (Danio rerio)
REACT:R-MMU-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Mus musculus)
RHEA:52519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline + ubiquinone-10 <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10
REACT:R-BTA-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Bos taurus)
REACT:R-CEL-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Caenorhabditis elegans)
REACT:R-CFA-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Canis familiaris)
REACT:R-CFA-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Canis familiaris)
RHEA:20405	skos:prefLabel	"N-acetyldiaminopimelate deacetylase"
RHEA:20405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate
RHEA:20405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyldiaminopimelate deacetylase"
REACT:R-CFA-3640858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase ADP-ribosylates AXIN (Canis familiaris)
REACT:R-GGA-5684248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Gallus gallus)
REACT:R-RNO-8848658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Rattus norvegicus)
REACT:R-MMU-8876191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 GEFs exchange GTP for GDP on RAB9 (Mus musculus)
REACT:R-MMU-8938076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD38 hydrolyses NAD+ to NAM and ADP-ribose (Mus musculus)
RHEA:48907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-SSC-1306969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)
RHEA:53056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine
REACT:R-HSA-8875591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK7 activates RAC1 (Homo sapiens)
RHEA:66694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein] => dTDP-beta-L-rhamnose + L-arginyl-[protein]
RHEA:51868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + umbelliferone = demethylsuberosin + diphosphate
REACT:R-SSC-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Sus scrofa)
REACT:R-SPO-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Schizosaccharomyces pombe)
REACT:R-DRE-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Danio rerio)
RHEA:61815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose <=> dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP
REACT:R-HSA-9026911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Homo sapiens)
REACT:R-RNO-73805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Rattus norvegicus)
RHEA:26363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+) => L-tyrosine + NADPH + S-adenosyl-L-methionine
REACT:R-GGA-2032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ), TBX5, and PCAF form a complex (Gallus gallus)
RHEA:10590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase] => 4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH
REACT:R-CEL-72231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Cleavage and Polyadenylation Complex (Caenorhabditis elegans)
GO:0010736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serum response element binding
REACT:R-MMU-2404193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1R phosphorylates SHC1 (Mus musculus)
REACT:R-DME-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Drosophila melanogaster)
GO:0015645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acyl-coenzyme A synthetase activity
GO:0015645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acid ligase activity
GO:0015645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid ligase activity
GO:0015645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acid CoA ligase activity
RHEA:55761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + a lyso-ornithine lipid => an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]
RHEA:33885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH => 2-deoxy-scyllo-inosamine + NAD(+)
REACT:R-HSA-2730849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
REACT:R-HSA-4331331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the PMAIP1 (NOXA) promoter (Homo sapiens)
RHEA:71035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + L-serine(in) = L-phenylalanine(in) + L-serine(out)
RHEA:41723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)
RHEA:50427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + 2 O2 <=> prostaglandin G1
RHEA:54990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O(in) => 4 e(-) + 4 H(+)(in) + O2(in)
RHEA:45470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate
RHEA:29592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate + NADP(+) => H(+) + NADPH + sulfoacetaldehyde
REACT:R-HSA-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
RHEA:63960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisate(out) + ATP + H2O = abscisate(in) + ADP + H(+) + phosphate
GO:0016497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	substance K receptor activity
GO:0016497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurokinin A receptor activity
GO:0016497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuromedin L receptor activity
REACT:R-BTA-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Bos taurus)
RHEA:14435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA with a 3' CCA end + 3 diphosphate => a tRNA precursor + ATP + 2 CTP
GO:0016251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTF2 activity
GO:0016251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly
GO:0016251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
GO:0016251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
GO:0016251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0016251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II general transcription initiation factor activity
GO:0016251	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
GO:0016251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	general RNA polymerase II transcription factor activity
GO:0016251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	basal RNA polymerase II transcription factor activity
RHEA:60180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-fructose(out) + H2O = ADP + D-fructose(in) + H(+) + phosphate
RHEA:24569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-phospho-beta-D-galactoside + H2O => an alcohol + D-galactose 6-phosphate
REACT:R-SSC-9706345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Sus scrofa)
RHEA:41050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA
GO:0009977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-pH-dependent protein transporter activity
GO:0009977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton motive force dependent protein transmembrane transporter activity
GO:0009977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	twin-arginine targeting transmembrane transporter activity
GO:0009977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pH-dependent protein transporter activity
GO:0009977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine targeting transmembrane transporter activity
REACT:R-CFA-417829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds ADP (Canis familiaris)
REACT:R-CFA-8849906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM1 binds NMDA receptor (Canis familiaris)
RHEA:69304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-glucotropeolin + H2O = (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
RHEA:21794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + H(+) + NADPH => NADP(+) + propan-2-ol
REACT:R-GGA-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Gallus gallus)
REACT:R-SSC-1602374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Sus scrofa)
REACT:R-XTR-216068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with Tenascin-C (Xenopus tropicalis)
RHEA:21773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(6666) in apoB mRNA + H(+) + H2O => NH4(+) + uridine(6666) in apoB mRNA
RHEA:66343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate
RHEA:46298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone
REACT:R-SSC-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Sus scrofa)
REACT:R-DRE-170978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-FRS2:CRKL binds C3G (Danio rerio)
REACT:R-XTR-193702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of the ICD migrates to the nucleus (Xenopus tropicalis)
REACT:R-RNO-446692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 binds to MYD88 within the IL1R complex (Rattus norvegicus)
RHEA:24382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet) => (6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet)
RHEA:22350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazol-4-one + NH4(+) => 4-aminoimidazole + H(+) + H2O
RHEA:65805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine
REACT:R-HSA-5690997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
REACT:R-XTR-6784399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Xenopus tropicalis)
REACT:R-DRE-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Danio rerio)
REACT:R-DRE-1306876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 activation by small molecules (Danio rerio)
RHEA:18686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + pentachlorophenol => 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)
RHEA:39613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH
GO:0050584	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	manganese lipoxygenase activity
GO:0050584	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate dioxygenase activity
GO:0050584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleate 11-lipoxygenase activity
GO:0050584	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate:oxygen 11S-oxidoreductase activity
RHEA:28554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate + H2O = D-mannose + phosphate
REACT:R-HSA-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
REACT:R-RNO-5610760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by ITCH (Rattus norvegicus)
REACT:R-MMU-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Mus musculus)
RHEA:49115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine
REACT:R-RNO-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Rattus norvegicus)
RHEA:45042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl => 2 Fe(III)-[cytochrome c] + hydroxylamine
GO:0102299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linolenate 9R-lipoxygenase activity
REACT:R-DME-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Drosophila melanogaster)
RHEA:39395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)
REACT:R-XTR-1112666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Xenopus tropicalis)
REACT:R-BTA-6805122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB binds TP53 (Bos taurus)
RHEA:23753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-undecaprenol + ATP => ADP + all-trans-undecaprenyl phosphate + H(+)
RHEA:21045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylidenelophenol + S-adenosyl-L-methionine => (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine
RHEA:40849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-eicosenoyl-CoA + FADH2 => eicosanoyl-CoA + FAD + H(+)
RHEA:60065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)
REACT:R-BTA-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Bos taurus)
REACT:R-DRE-9748996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers cleave AZA to 6MP (Danio rerio)
GO:0015562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	efflux permease activity
GO:0015562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	efflux transporter activity
GO:0015562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	efflux transmembrane transporter activity
GO:0015562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
REACT:R-RNO-2066780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)
RHEA:60111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-(4-hydroxyphenyl)lactoyl-CoA <=> (E)-4-coumaroyl-CoA + H2O
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	camphor 5-exo-hydroxylase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylene monooxygenase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	camphor hydroxylase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bornanone 5-exo-hydroxylase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-bornanone 5-exo-hydroxylase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	camphor methylene hydroxylase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome p450-cam activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-camphor-exo-hydroxylase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	camphor 5-exohydroxylase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	camphor 5-exo-methylene hydroxylase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	camphor 5-monooxygenase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	d-camphor monooxygenase activity
GO:0018683	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylene hydroxylase activity
RHEA:22369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose 5-phosphate => D-xylulose 5-phosphate
REACT:R-HSA-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Homo sapiens)
REACT:R-RNO-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Rattus norvegicus)
REACT:R-HSA-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Homo sapiens)
RHEA:59141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + N(5)-[(S)-citryl]-D-ornithine => AMP + diphosphate + H(+) + staphyloferrin A
REACT:R-GGA-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Gallus gallus)
REACT:R-RNO-4647594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAHF formation (Rattus norvegicus)
RHEA:47938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 H(+) + NADPH => 4-hydroxybenzaldehyde + H2O + NADP(+)
REACT:R-DRE-141367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylation of tBID by NMT1 (Danio rerio)
REACT:R-MMU-2022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to heparan (Mus musculus)
REACT:R-HSA-8950741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B:IL23A translocates from ER lumen to extracellular space (Homo sapiens)
REACT:R-SSC-6809254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR8 binds MTMR9 (Sus scrofa)
RHEA:52671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH
GO:0002113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-33 binding
GO:0002113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-33 binding
RHEA:66943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine <=> 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B
REACT:R-DME-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Drosophila melanogaster)
REACT:R-XTR-9749197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 binds to H4K20me2 (Xenopus tropicalis)
RHEA:34424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-secoisolariciresinol + NADP(+) => (+)-lariciresinol + H(+) + NADPH
REACT:R-HSA-1980051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLL4 binds NOTCH2 (Homo sapiens)
REACT:R-DDI-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Dictyostelium discoideum)
REACT:R-DME-159425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
REACT:R-GGA-112381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Gallus gallus)
RHEA:33823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH = NAD(+) + tetrahydro-4-hydroxyphenylpyruvate
GO:1990888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-polyprenyl-6-hydroxyphenol O-methyltransferase activity
REACT:R-XTR-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Xenopus tropicalis)
RHEA:24796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate
REACT:R-XTR-1168894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A/B dissociates from the Growth Hormone receptor (Xenopus tropicalis)
RHEA:11180	skos:altLabel	"asparaginyl-tRNA synthetase"
RHEA:11180	skos:altLabel	"asparagine translase"
RHEA:11180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"asparagine--tRNA ligase"
RHEA:11180	skos:prefLabel	"asparagine--tRNA ligase"
RHEA:11180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)
REACT:R-HSA-1912364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR181C microRNA binds 3'UTR of NOTCH4 mRNA (Homo sapiens)
REACT:R-DME-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Drosophila melanogaster)
RHEA:23951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + NAD(+) <=> H(+) + NADH + succinate semialdehyde
REACT:R-DME-6786652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIT1 hydrolyses CHIT to 3xADGP (Drosophila melanogaster)
REACT:R-PFA-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Plasmodium falciparum)
RHEA:37226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA
REACT:R-BTA-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Bos taurus)
REACT:R-XTR-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Xenopus tropicalis)
REACT:R-HSA-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)
RHEA:50211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + NAD(+) <=> cortisone + H(+) + NADH
REACT:R-GGA-1307955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds HS:KLB:FGF19 (Gallus gallus)
RHEA:43367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose <=> beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP
REACT:R-RNO-1250346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Rattus norvegicus)
RHEA:65214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoate + CoA + H(+) => (2E)-dodecenoyl-CoA + H2O
RHEA:35559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinone-7 + NADH = menaquinol-7 + NAD(+)
RHEA:28200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetophenone + H(+) + NADH => (S)-1-phenylethanol + NAD(+)
GO:0015152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-6-phosphate transmembrane transporter activity
RHEA:32915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycero-3-phospho-1D-myo-inositol(out) = sn-glycero-3-phospho-1D-myo-inositol(in)
REACT:R-RNO-2002401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Rattus norvegicus)
REACT:R-CFA-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
REACT:R-RNO-1370505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR is phosphorylated at Ser-349 (Rattus norvegicus)
REACT:R-MMU-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Mus musculus)
GO:0019909	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity
GO:0019909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity
REACT:R-GGA-877187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates loss of intracellular K+ (Gallus gallus)
RHEA:20476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)
RHEA:10002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + pentanoate => H2O + pentanamide
RHEA:54337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:61332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + indoxyl sulfate(in) = ADP + H(+) + indoxyl sulfate(out) + phosphate
RHEA:62847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)
REACT:R-CFA-9645394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Canis familiaris)
REACT:R-XTR-904864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Xenopus tropicalis)
REACT:R-DRE-373747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of nephrin by FYN (Danio rerio)
RHEA:57984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP
RHEA:38158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (6E,10E)-geranyllinalool + diphosphate
REACT:R-BTA-8952039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Bos taurus)
REACT:R-CFA-5672961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates inactive RAFs (Canis familiaris)
REACT:R-HSA-418863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Shp2 binds pUnc5C (Homo sapiens)
REACT:R-DDI-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Dictyostelium discoideum)
RHEA:18867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA
RHEA:24225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) => 4-methylcatechol + CO2 + NADPH
REACT:R-MMU-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Mus musculus)
RHEA:23643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 <=> CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate
REACT:R-XTR-5609665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHUK, IKBKB and IKBKG form IKK complex (Xenopus tropicalis)
REACT:R-RNO-8871193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
GO:0051507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-sitosterol UDP-glucosyltransferase activity
GO:0051507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sitosterol + UDP-alpha-D-glucose = H(+) + sitosteryl 3-beta-D-glucoside + UDP
REACT:R-HSA-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Homo sapiens)
REACT:R-CFA-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)
RHEA:24956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-muramate 6-phosphate = (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate
REACT:R-XTR-3785711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Telomere shortening during replicative exhaustion (Xenopus tropicalis)
GO:0015423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltose-transporting ATPase activity
GO:0015423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent maltose transmembrane transporter activity
GO:0015423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type maltose transporter activity
GO:0015423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltooligosaccharide-importing ATPase activity
GO:0015423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type maltose transporter
GO:0015423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose ABC transporter
GO:0015423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled maltose transmembrane transporter activity
REACT:R-CFA-5668543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3:NIK binds TRAF2:cIAP1/2 (Canis familiaris)
REACT:R-GGA-5682863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF168 binds DNA DSBs (Gallus gallus)
RHEA:65250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O => AH2 + 5 H(+) + 5 malonyl-CoA
RHEA:50037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine
RHEA:65323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chrodrimanin E + O2 <=> chrodrimanin A + CO2 + succinate
REACT:R-BTA-606326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HJURP:CENPA complex localizes to the centromere (Bos taurus)
REACT:R-SSC-5689973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10,USP24,USP42 deubiquitinate TP53 (Sus scrofa)
REACT:R-MMU-3965450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits PFN1 (Mus musculus)
RHEA:23703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + H2O <=> (6S)-10-formyltetrahydrofolate + H(+)
GO:0030267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolate:NADP+ oxidoreductase activity
GO:0030267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate reductase (NADP+)
GO:0030267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-glyoxylate reductase activity
GO:0030267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + NADP(+) = glyoxylate + H(+) + NADPH
GO:0030267	skos:prefLabel	"glyoxylate reductase (NADP(+))"
GO:0030267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyoxylate reductase (NADP(+))"
GO:0030267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate reductase (NADP+) activity
REACT:R-MMU-373717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacts with DIP13alpha (Mus musculus)
RHEA:37096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA
GO:0034029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OGC
GO:0034029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate carboxylase activity
GO:0034029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxylating factor for ICDH
GO:0034029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalosuccinate synthetase activity
GO:0034029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CFI
REACT:R-GGA-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Gallus gallus)
REACT:R-HSA-5654407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates SHC1 (Homo sapiens)
REACT:R-HSA-9705145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1, IKBKE form homodimers (Homo sapiens)
RHEA:19787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clavaminate + CO2 + H2O + succinate => 2-oxoglutarate + dihydroclavaminate + O2
REACT:R-SSC-193691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kB migrates to the nucleus and turns on transcription (Sus scrofa)
REACT:R-GGA-2213017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF3 (Gallus gallus)
REACT:R-CFA-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Canis familiaris)
REACT:R-DME-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Drosophila melanogaster)
RHEA:14233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA
RHEA:14233	skos:prefLabel	"2-acylglycerol-3-phosphate O-acyltransferase"
RHEA:14233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-acylglycerol-3-phosphate O-acyltransferase"
REACT:R-CFA-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Canis familiaris)
RHEA:49328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Mus musculus)
REACT:R-BTA-508247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
REACT:R-MMU-71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Mus musculus)
REACT:R-HSA-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Homo sapiens)
REACT:R-SSC-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Sus scrofa)
REACT:R-BTA-9700149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds PLCG1 (Bos taurus)
REACT:R-RNO-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
REACT:R-SSC-375340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 62 mediated neuronal gap junction communication (Sus scrofa)
RHEA:51999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:68104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone
REACT:R-DME-9023968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Drosophila melanogaster)
REACT:R-BTA-77584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Bos taurus)
REACT:R-CFA-2584246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT1-GTP hydrolyses its bound GTP to GDP (Canis familiaris)
RHEA:58045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + alpha,alpha-trehalose => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA
RHEA:50339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate <=> H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Schizosaccharomyces pombe)
REACT:R-CFA-8865637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFSD2A transports LPC from extracellular region to plasma membrane (Canis familiaris)
REACT:R-GGA-8987097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Gallus gallus)
REACT:R-BTA-5666104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Bos taurus)
REACT:R-BTA-5676589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANKL,sRANKL trimer binds RANK (Bos taurus)
REACT:R-MMU-5651723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)
RHEA:23875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-propane-1,2-diol + NAD(+) <=> (R)-lactaldehyde + H(+) + NADH
REACT:R-DRE-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Danio rerio)
RHEA:39758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-976810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to extracellular Factor H:C3b (Canis familiaris)
REACT:R-HSA-5632672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRBK1 phosphorylates SMO dimer (Homo sapiens)
GO:0000721	skos:altLabel	"(R)-diacetyl reductase"
GO:0000721	skos:altLabel	"D-aminopropanol dehydrogenase"
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-1-amino-2-propanol dehydrogenase activity
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyleneglycol dehydrogenase activity
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butylene glycol dehydrogenase activity
GO:0000721	skos:altLabel	"(R)-2,3-butanediol dehydrogenase"
GO:0000721	skos:altLabel	"2,3-butanediol dehydrogenase"
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-amino-2-propanol oxidoreductase activity
GO:0000721	skos:altLabel	"1-amino-2-propanol dehydrogenase"
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-1-amino-2-propanol:NAD(2) oxidoreductase activity
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-butanediol dehydrogenase activity
GO:0000721	skos:altLabel	"D-1-amino-2-propanol:NAD(2) oxidoreductase"
GO:0000721	skos:altLabel	"butyleneglycol dehydrogenase"
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH
GO:0000721	skos:altLabel	"D-butanediol dehydrogenase"
GO:0000721	skos:altLabel	"aminopropanol oxidoreductase"
GO:0000721	skos:altLabel	"butylene glycol dehydrogenase"
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminopropanol oxidoreductase activity
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-diacetyl reductase activity
GO:0000721	skos:altLabel	"D-(-)-butanediol dehydrogenase"
GO:0000721	skos:altLabel	"1-amino-2-propanol oxidoreductase"
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-butanediol dehydrogenase activity
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2,3-butanediol dehydrogenase activity
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aminopropanol dehydrogenase activity
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-amino-2-propanol dehydrogenase activity
GO:0000721	skos:altLabel	"diacetyl (acetoin) reductase"
GO:0000721	skos:altLabel	"D-1-amino-2-propanol dehydrogenase"
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-butanediol dehydrogenase activity
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diacetyl (acetoin) reductase activity
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R,R)-butanediol dehydrogenase"
GO:0000721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-(-)-butanediol dehydrogenase activity
GO:0000721	skos:prefLabel	"(R,R)-butanediol dehydrogenase"
REACT:R-RNO-9686088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDMD (Rattus norvegicus)
RHEA:61840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brassicasterol + UDP-alpha-D-glucose = brassicasterol 3-beta-D-glucoside + H(+) + UDP
REACT:R-GGA-8854905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Gallus gallus)
GO:0018787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-chlorobenzoyl CoA chlorohydrolase activity
GO:0018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoyl-CoA dehalogenase activity
RHEA:47801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-methionine
REACT:R-XTR-8982640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Xenopus tropicalis)
RHEA:48916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b = CMP + ganglioside GD1c + H(+)
REACT:R-SCE-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Saccharomyces cerevisiae)
REACT:R-HSA-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Homo sapiens)
REACT:R-MMU-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Mus musculus)
REACT:R-HSA-2769000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants bind DLL4 (Homo sapiens)
REACT:R-CFA-2022403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)
REACT:R-HSA-6799097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates ZNF420 (Homo sapiens)
REACT:R-MMU-389352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Vav1 to CD28 (Mus musculus)
REACT:R-XTR-5624956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds INPP5E (Xenopus tropicalis)
REACT:R-RNO-1112690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds CBL (Rattus norvegicus)
REACT:R-RNO-6786245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNS1 transforms ATP, L-His, b-Ala to CARN (Rattus norvegicus)
REACT:R-MMU-73920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Mus musculus)
REACT:R-DRE-3928640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs phosphorylate MLC (Danio rerio)
REACT:R-CFA-5684108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 binds phosphorylated RBBP8 (Canis familiaris)
REACT:R-RNO-71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Rattus norvegicus)
GO:0018526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzoyl-CoA reductase activity
REACT:R-DME-374686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 interaction with Integrins (Drosophila melanogaster)
GO:0031731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR6 chemokine receptor binding
GO:0031731	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR6 chemokine receptor ligand
GO:0031731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARC receptor binding
REACT:R-CFA-2671885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers:H+ transport extracellular Na+ to cytosol (Canis familiaris)
REACT:R-DDI-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)
REACT:R-BTA-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Bos taurus)
GO:0047654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine sulfoxide lyase activity
GO:0047654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylcysteine sulfoxide lyase activity
GO:0047654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine sulphoxide lyase activity
GO:0047654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alliin lyase activity
GO:0047654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine sulfoxide lyase activity
GO:0047654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-alkylcysteine sulfoxide lyase activity
GO:0047654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alliin alkyl-sulfenate-lyase activity
GO:0047654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alliinase activity
GO:0047654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-alkyl-L-cysteine S-oxide = 2-aminoprop-2-enoate + an S-alkyl sulfenate
GO:0047654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)
REACT:R-CEL-77586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Caenorhabditis elegans)
REACT:R-DME-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Drosophila melanogaster)
RHEA:72839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + CoA(in) = ADP(in) + CoA(out)
GO:0050311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin-sulfite reductase activity
GO:0050311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite
GO:0050311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite reductase (ferredoxin) activity
GO:0050311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen-sulfide:ferredoxin oxidoreductase activity
GO:0050311	skos:altLabel	"sulfite reductase (ferredoxin)"
GO:0050311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"assimilatory sulfite reductase (ferredoxin)"
GO:0050311	skos:prefLabel	"assimilatory sulfite reductase (ferredoxin)"
GO:0050311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphite reductase (ferredoxin) activity
RHEA:43442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoylsphinganine => hexadecanoate + sphinganine
REACT:R-CFA-5607728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
RHEA:22966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + putrescine => H(+) + L-ornithine
REACT:R-CEL-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Caenorhabditis elegans)
RHEA:61125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin
REACT:R-BTA-75079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC C complex (Bos taurus)
REACT:R-SSC-5099886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binding to FZD promotes PRICKLE1 degradation (Sus scrofa)
RHEA:31942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] <=> DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxononanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxynonanoyl-[ACP] + NADP(+)
REACT:R-HSA-5627275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOPC promotes translocation of CFTR to lysosomes (Homo sapiens)
RHEA:70920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + dopamine(out) + Na(+)(out) => chloride(in) + dopamine(in) + Na(+)(in)
RHEA:66013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O
REACT:R-SCE-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)
REACT:R-SSC-3788061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by ADAM8 (Sus scrofa)
REACT:R-SSC-9679740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA4:ITGB1 binds natalizumab (Sus scrofa)
GO:0008780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity
GO:0008780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine acyltransferase activity
GO:0008780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine acyltransferase activity
GO:0008780	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase
GO:0008780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity
GO:0008780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
GO:0008780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity
REACT:R-RNO-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Rattus norvegicus)
REACT:R-SSC-187035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-beta-NGF and mature beta-NGF are secreted (Sus scrofa)
RHEA:18314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile => benzaldehyde + hydrogen cyanide
GO:0102237	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent farnesol kinase activity
GO:0102237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:farnesol kinase activity
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	delta(11)-fatty-acid desaturase
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA 11-(Z)-desaturase"
GO:0017105	skos:altLabel	"Delta(11) desaturase"
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	delta(11)-palmitoyl-CoA desaturase
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fatty acid delta(11)-desaturase
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acyl-CoA delta11-desaturase activity
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA D11-desaturase activity
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA delta11-(Z)-desaturase activity
GO:0017105	skos:prefLabel	"acyl-CoA 11-(Z)-desaturase"
GO:0017105	skos:altLabel	"Delta(11)-palmitoyl-CoA desaturase"
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA delta(11)-desaturase activity
GO:0017105	skos:altLabel	"Delta(11)-fatty-acid desaturase"
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	delta(11) desaturase
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myristoyl-CoA 11-(Z) desaturase activity
GO:0017105	skos:altLabel	"fatty acid Delta(11)-desaturase"
GO:0017105	skos:altLabel	"Z/E11-desaturase"
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0017105	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Z/E11-desaturase
REACT:R-DRE-4719448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO3 (Danio rerio)
RHEA:47729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)
REACT:R-SSC-380949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK is dephosphorylated (Sus scrofa)
REACT:R-DRE-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)
RHEA:40153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+) => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O
REACT:R-SPO-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)
RHEA:11609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA
GO:0030603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalacetic hydrolase activity
GO:0030603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetase activity
GO:0030603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxaloacetate acetylhydrolase activity
REACT:R-HSA-8873834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 transports PC from ER membrane to lamellar body membrane (Homo sapiens)
REACT:R-BTA-1112565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Bos taurus)
RHEA:56809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] => adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate
REACT:R-BTA-6787533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Bos taurus)
REACT:R-XTR-76475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Xenopus tropicalis)
RHEA:63911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + pravastatin(in) <=> ADP + H(+) + phosphate + pravastatin(out)
RHEA:28924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-phenylalanine(in) => H(+)(out) + L-phenylalanine(out)
RHEA:12693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)
RHEA:12693	skos:prefLabel	"L-mimosine synthase"
RHEA:12693	skos:altLabel	"O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)"
RHEA:12693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-mimosine synthase"
RHEA:56370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+) => 3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2
RHEA:46199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0005356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transepithelial hydrogen:glucose transporter activity
GO:0005356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen:glucose symporter activity
GO:0005356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:glucose transporter activity
GO:0005356	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transepithelial hydrogen:glucose symporter activity
GO:0005356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose:proton symporter activity
GO:0005356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transepithelial hydrogen/glucose transporter activity
RHEA:52035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine-(+)-7-isojasmonate <=> (+)-7-isojasmonate + L-isoleucine
REACT:R-SPO-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)
REACT:R-GGA-8871226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA2 (Gallus gallus)
RHEA:68280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + pentanoyl-CoA = CoA + O-pentanoyl-L-seryl-[protein]
REACT:R-RNO-1861789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Rattus norvegicus)
REACT:R-HSA-9008015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STAT1 (Homo sapiens)
RHEA:38110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-galactonate <=> L-glyceraldehyde + pyruvate
GO:0010334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sesquiterpene synthase activity
REACT:R-DME-350385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSH binds to RAC1:GTP (Drosophila melanogaster)
REACT:R-MMU-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Mus musculus)
RHEA:53343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20) in tRNA
GO:0031702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 angiotensin receptor binding
GO:0031702	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 angiotensin receptor ligand
GO:0031702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AT1 receptor binding
REACT:R-GGA-3132737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate ETS1 and ETS2 (Gallus gallus)
RHEA:54591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine in 25S rRNA <=> H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine
REACT:R-CEL-400037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi,Go Heterotrimeric G-protein complex dissociates (Caenorhabditis elegans)
RHEA:46060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:41709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)
RHEA:34858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + iminodiacetonitrile <=> N-(cyanomethyl)glycine + NH4(+)
GO:0008515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose permease activity
GO:0008515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose transmembrane transporter activity
GO:0008515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose permease (PTS) activity
REACT:R-MMU-2160892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Mus musculus)
REACT:R-DRE-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Danio rerio)
REACT:R-MMU-927813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
REACT:R-SCE-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Saccharomyces cerevisiae)
REACT:R-XTR-622325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)
RHEA:19103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-butynal + H(+) + NADH => 2-butyne-1,4-diol + NAD(+)
RHEA:41057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA
REACT:R-MMU-2424487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)
REACT:R-XTR-5651654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)
GO:0106255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroperoxy icosatetraenoate isomerase activity
REACT:R-SSC-9011595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Sus scrofa)
REACT:R-HSA-8939706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) polyubiquitinates RUNX2 (Homo sapiens)
REACT:R-SCE-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Saccharomyces cerevisiae)
REACT:R-DRE-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Danio rerio)
RHEA:31540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + S-adenosyl-L-methionine => (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Sus scrofa)
REACT:R-RNO-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Rattus norvegicus)
RHEA:70053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate => 2-oxoadipate + L-kynurenine
REACT:R-CFA-2730886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC by SYK kinase (Canis familiaris)
REACT:R-HSA-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Homo sapiens)
GO:0090448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosinolate:proton symporter activity
GO:0090448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosinolate:hydrogen symporter activity
REACT:R-HSA-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Homo sapiens)
REACT:R-DME-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Drosophila melanogaster)
GO:0070325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoprotein particle receptor binding
REACT:R-SSC-176604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Sus scrofa)
REACT:R-RNO-69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk1 (Rattus norvegicus)
REACT:R-XTR-3134883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin enhances association of IRF3 with CBP/p300  (Xenopus tropicalis)
RHEA:14049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taxadiene 5alpha-hydroxylase"
RHEA:14049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol
RHEA:14049	skos:prefLabel	"taxadiene 5alpha-hydroxylase"
RHEA:61293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + NAD(+) => 2-dehydropantoate + H(+) + NADH
RHEA:64243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + octanoyl-CoA <=> CoA + H(+) + N-octanoylglycine
RHEA:28534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP + H2O = diphosphate + dTMP + H(+)
REACT:R-SSC-8950441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Sus scrofa)
RHEA:40982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate
REACT:R-HSA-9654774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcription of PPP1R15A (Homo sapiens)
RHEA:70517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose
REACT:R-MMU-1449687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticosteroids bind to CBG in blood (Mus musculus)
REACT:R-RNO-2028724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind YAP1 (Rattus norvegicus)
RHEA:39015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-oxodocosanoate + H2O + NAD(+) = docosanedioate + 2 H(+) + NADH
REACT:R-DRE-9680865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4, CYP2B6 bind ritonavir (Danio rerio)
GO:0031886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 member 3 taste receptor binding
GO:0031886	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 member 3 taste receptor ligand
GO:0031886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sweet taste receptor binding
RHEA:30071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + butanoate = acetate + butanoyl-CoA
REACT:R-SSC-193702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of the ICD migrates to the nucleus (Sus scrofa)
GO:0016716	skos:prefLabel	"With another compound as one donor, and incorporation of one atom of oxygen"
GO:0016716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With another compound as one donor, and incorporation of one atom of oxygen"
GO:0016716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
RHEA:53413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
REACT:R-SSC-1638053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from keratan sulfate (Sus scrofa)
GO:0070191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine-R-sulfoxide reductase activity
RHEA:20294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH
REACT:R-HSA-174097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdh1 (Homo sapiens)
RHEA:30545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitinyl-CoA + ADP + phosphate => (S)-carnitine + ATP + CoA
GO:0008409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-3' exonuclease activity
REACT:R-DRE-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Danio rerio)
REACT:R-RNO-9021609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR-associated SRC autophosphorylates (Rattus norvegicus)
REACT:R-CEL-8849068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARHGAP35 (Caenorhabditis elegans)
REACT:R-GGA-5604929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C binds Protein S (Gallus gallus)
REACT:R-HSA-8873929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates STARD10 (Homo sapiens)
RHEA:18032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + hydrogencarbonate + NH4(+) <=> 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate
RHEA:30523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coenzyme F420-1:gamma-L-glutamate ligase"
RHEA:30523	skos:prefLabel	"coenzyme F420-1:gamma-L-glutamate ligase"
RHEA:30523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate
RHEA:12827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + H(+) + phosphate + sarcosine => [thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine
REACT:R-SCE-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Saccharomyces cerevisiae)
REACT:R-DRE-3451153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits TRRAP/KAT5 HAT components (Danio rerio)
RHEA:60724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + H2O + NADP(+) = dodecanoate + 2 H(+) + NADPH
REACT:R-CEL-6805205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR35 binds kynurenic acid (Caenorhabditis elegans)
RHEA:31090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + octanoyl-CoA <=> 3-oxodecanoyl-CoA + CoA
EC:3.2.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan 1,4-alpha-glucosidase"
EC:3.2.1.3	skos:prefLabel	"glucan 1,4-alpha-glucosidase"
EC:3.2.1.3	skos:altLabel	"lysosomal alpha-glucosidase"
EC:3.2.1.3	skos:altLabel	"exo-1,4-alpha-glucosidase"
EC:3.2.1.3	skos:altLabel	"gamma-amylase"
EC:3.2.1.3	skos:altLabel	"glucoamylase"
EC:3.2.1.3	skos:altLabel	"amyloglucosidase"
EC:3.2.1.3	skos:altLabel	"4-alpha-D-glucan glucohydrolase"
REACT:R-HSA-5362549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np traffics to the plasma membrane (Homo sapiens)
REACT:R-HSA-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Homo sapiens)
REACT:R-CFA-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Canis familiaris)
RHEA:31958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0052729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity
GO:0052729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylglycine N-methyltransferase activity
GO:0052729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ApDMT
EC:3.4.13.20	skos:prefLabel	"beta-Ala-His dipeptidase"
EC:3.4.13.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-Ala-His dipeptidase"
EC:3.4.13.20	skos:altLabel	"serum carnosinase"
REACT:R-MMU-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Mus musculus)
REACT:R-SPO-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Schizosaccharomyces pombe)
REACT:R-HSA-6805546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I binds keratin type II (Homo sapiens)
REACT:R-HSA-9731018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 M binds to PDPK1 (Homo sapiens)
REACT:R-HSA-379867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)
REACT:R-GGA-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Gallus gallus)
RHEA:34937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ATP + H(+)
REACT:R-HSA-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Homo sapiens)
REACT:R-BTA-6788385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of ATR and ATRIP is recruited to ICL-DNA (Bos taurus)
REACT:R-RNO-9750666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds ST (Rattus norvegicus)
REACT:R-HSA-5658104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNCAIP binds alpha-synuclein (Homo sapiens)
RHEA:37994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocopherol + S-adenosyl-L-methionine <=> beta-tocopherol + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-190427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1b (Drosophila melanogaster)
REACT:R-CFA-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Canis familiaris)
RHEA:58632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-tetradecanoyl-(2S)-hydroxyglycine = glyoxylate + tetradecamide
RHEA:42300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]
RHEA:42300	skos:prefLabel	"glycerol-3-phosphate acyltransferase (acyl-[acyl-carrier-protein]-transferring)"
RHEA:42300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-3-phosphate acyltransferase (acyl-[acyl-carrier-protein]-transferring)"
RHEA:34410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP <=> 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate
REACT:R-HSA-192312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Homo sapiens)
GO:0016802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioether hydrolase activity
GO:0016802	skos:prefLabel	"Thioether and trialkylsulfonium hydrolases"
GO:0016802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trialkylsulphonium hydrolase activity
GO:0016802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Thioether and trialkylsulfonium hydrolases"
GO:0016802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trialkylsulfonium hydrolase activity
REACT:R-DME-3134953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 or DHX9 binds MyD88 (Drosophila melanogaster)
REACT:R-DME-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Drosophila melanogaster)
REACT:R-MMU-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Mus musculus)
RHEA:32114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-resveratrol <=> 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine
RHEA:35977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + CO2 + H2O + succinate + verruculogen => 2-oxoglutarate + AH2 + fumitremorgin B + 2 O2
RHEA:61808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP = AMP + H(+) + L-alanyl-[peptidyl-carrier protein]
REACT:R-HSA-8852337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds TP53 (Homo sapiens)
REACT:R-BTA-5690991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Bos taurus)
RHEA:16624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + H(+) + O2 <=> H2O2 + sanguinarine
RHEA:64482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate
REACT:R-MMU-5669023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TWEAK binds FN14 (Mus musculus)
RHEA:36424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine
RHEA:47688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-hydroxy-L-proline + NADP(+) = Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH
REACT:R-XTR-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)
REACT:R-XTR-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Xenopus tropicalis)
RHEA:35229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + rifampicin(out) => H(+)(out) + rifampicin(in)
RHEA:38326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol
RHEA:53341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20) in tRNA + NAD(+) => H(+) + NADH + uridine(20) in tRNA
RHEA:56849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-didemethyltoxoflavin + S-adenosyl-L-methionine => H(+) + reumycin + S-adenosyl-L-homocysteine
RHEA:36281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theophylline
RHEA:49991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + H(+) + NADPH + O2 <=> H2O + methyl acetate + NADP(+)
RHEA:43264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-RNO-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Rattus norvegicus)
REACT:R-DME-391939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP receptor can bind thromboxane (Drosophila melanogaster)
RHEA:25277	skos:altLabel	"cAMP-specific phosphodiesterase"
RHEA:25277	skos:altLabel	"cAMP-specific PDE"
RHEA:25277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP + H2O = AMP + H(+)
RHEA:25277	skos:prefLabel	"3',5'-cyclic-AMP phosphodiesterase"
RHEA:25277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3',5'-cyclic-AMP phosphodiesterase"
RHEA:26470	skos:prefLabel	"omega-hydroxypalmitate O-feruloyl transferase"
RHEA:26470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"omega-hydroxypalmitate O-feruloyl transferase"
RHEA:26470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + 16-hydroxyhexadecanoate = 16-feruloyloxyhexadecanoate + CoA
RHEA:26470	skos:altLabel	"HHT"
RHEA:26470	skos:altLabel	"hydroxycinnamoyl-CoA omega-hydroxypalmitic acid O-hydroxycinnamoyltransferase"
RHEA:35904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-BTA-4085296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NCOA1 with SUMO1 (Bos taurus)
GO:0050809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Valium binding
GO:0050809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diazepam binding
GO:0050809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diazepam binding inhibitor activity
REACT:R-SSC-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Sus scrofa)
REACT:R-CFA-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Canis familiaris)
GO:0033783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP7B1
GO:0033783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity
GO:0033783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] = (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0033783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP7B1 oxysterol 7alpha-hydroxylase activity
GO:0033783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholesterol 7alpha-hydroxylase activity
GO:0033783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	25-hydroxycholesterol 7alpha-monooxygenase activity
REACT:R-HSA-2299620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen XI cross-links with collagen II (Homo sapiens)
REACT:R-CEL-77309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Caenorhabditis elegans)
REACT:R-DME-5660980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S276-RELA binds RELB (Drosophila melanogaster)
REACT:R-XTR-9026894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK2 (Xenopus tropicalis)
RHEA:14836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + CoA + 2 NAD(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH
REACT:R-BTA-9687638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds IP4, IP5 and IP6  (Bos taurus)
REACT:R-CFA-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Canis familiaris)
REACT:R-DME-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Drosophila melanogaster)
GO:0004132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP deaminase activity
GO:0004132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dCMP aminohydrolase activity
GO:0004132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidine-5'-phosphate deaminase activity
GO:0004132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidylate deaminase activity
GO:0004132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxy-CMP-deaminase activity
GO:0004132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidine-5'-monophosphate aminohydrolase activity
GO:0004132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidylate aminohydrolase activity
GO:0004132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidine monophosphate deaminase activity
REACT:R-SCE-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)
RHEA:13019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + uracil => diphosphate + UMP
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthylic pyrophosphorylase activity
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xanthine phosphoribosyltransferase"
GO:0000310	skos:altLabel	"XMP pyrophosphorylase"
GO:0000310	skos:prefLabel	"xanthine phosphoribosyltransferase"
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthylate pyrophosphorylase activity
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Xan phosphoribosyltransferase activity
GO:0000310	skos:altLabel	"xanthosine 5'-phosphate pyrophosphorylase"
GO:0000310	skos:altLabel	"xanthylate pyrophosphorylase"
GO:0000310	skos:altLabel	"xanthine-guanine phosphoribosyltransferase"
GO:0000310	skos:altLabel	"Xan phosphoribosyltransferase"
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthine phosphoribosyltransferase activity
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	XMP pyrophosphorylase activity
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthosine 5'-phosphate pyrophosphorylase activity
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthine-guanine phosphoribosyltransferase activity
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity
GO:0000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
GO:0000310	skos:altLabel	"xanthylic pyrophosphorylase"
REACT:R-RNO-9647746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 trimerizes (Rattus norvegicus)
REACT:R-HSA-5368586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKK promotes clathrin-dependent internalization of LRP6 (Homo sapiens)
RHEA:28545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetyl-CoA + H2O <=> CoA + fluoroacetate + H(+)
RHEA:50018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine => H2O + octanoyl-CoA
RHEA:13347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => (2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein]
RHEA:48595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + formate + H(+) <=> a quinol + CO2
RHEA:15256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate + H(+) <=> CO2 + itaconate
RHEA:14240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine
REACT:R-MMU-5654631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PPTN11 (Mus musculus)
RHEA:59761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin + UDP-alpha-D-glucose => apigenin 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-SSC-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Sus scrofa)
REACT:R-DRE-174587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Danio rerio)
REACT:R-HSA-606326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HJURP:CENPA complex localizes to the centromere (Homo sapiens)
REACT:R-XTR-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)
REACT:R-DME-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Drosophila melanogaster)
REACT:R-CFA-444620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide S receptor binds neuropeptide S (Canis familiaris)
REACT:R-GGA-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Gallus gallus)
REACT:R-SSC-5607724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
REACT:R-XTR-166214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion flip-flops to the opposite surface (Xenopus tropicalis)
REACT:R-BTA-9009308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 polyubiquitinates RUNX2 (Bos taurus)
RHEA:54146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2
REACT:R-HSA-9029667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DFF dissociates from importin-alpha:importin-beta (Homo sapiens)
REACT:R-RNO-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Rattus norvegicus)
GO:1990538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylan O-acetyltransferase activity
REACT:R-SSC-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Sus scrofa)
REACT:R-RNO-5362459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)
REACT:R-SSC-5621355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Sus scrofa)
REACT:R-SSC-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Sus scrofa)
REACT:R-DRE-74742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 (Danio rerio)
REACT:R-DRE-1855225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Danio rerio)
REACT:R-HSA-1181149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Homo sapiens)
REACT:R-SSC-5634802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Sus scrofa)
REACT:R-SPO-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Schizosaccharomyces pombe)
REACT:R-SSC-2404135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4 binds atROL (Sus scrofa)
RHEA:19331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP => nuatigenin + UDP-alpha-D-glucose
REACT:R-BTA-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)
RHEA:46527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:17662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + succinate => ADP + phosphate + succinyl-CoA
REACT:R-CEL-6810410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)
RHEA:48043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + H2O <=> globoside Gb3Cer + N-acetyl-beta-D-galactosamine
REACT:R-RNO-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Rattus norvegicus)
REACT:R-DRE-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Danio rerio)
REACT:R-HSA-3134822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds viral dsDNA  (Homo sapiens)
REACT:R-SCE-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Saccharomyces cerevisiae)
REACT:R-HSA-8985227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter (Homo sapiens)
REACT:R-HSA-5628905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Homo sapiens)
RHEA:32585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2
RHEA:13039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITP + NH4(+) => ATP + H(+) + H2O
REACT:R-XTR-8856157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAG3 (CD233) binds MHC II (Xenopus tropicalis)
REACT:R-HSA-201640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Homo sapiens)
REACT:R-GGA-199917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates CREB at Serine 133 (Gallus gallus)
RHEA:15550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O
REACT:R-CFA-216076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Canis familiaris)
REACT:R-BTA-5336184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37L binds prosaposin (Bos taurus)
RHEA:70949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan(out) => L-tryptophan(in)
REACT:R-XTR-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Xenopus tropicalis)
RHEA:22702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:35599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADPH
REACT:R-CFA-158354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Canis familiaris)
REACT:R-DDI-168400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iE-DAP elicits a NOD1 response (Dictyostelium discoideum)
REACT:R-CFA-975608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP2:atROL and FACYLs to atREs (Canis familiaris)
RHEA:44269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-CEL-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Caenorhabditis elegans)
RHEA:61192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
REACT:R-DDI-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Dictyostelium discoideum)
REACT:R-RNO-8950441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Rattus norvegicus)
GO:0033420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUG codon-amino acid adaptor activity
GO:0033420	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine tRNA
GO:0033420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTG codon-amino acid adaptor activity
RHEA:55744	skos:prefLabel	"coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase"
RHEA:55744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase"
RHEA:55744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:25987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:30886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucurono-3,6-lactone + 2 H2O + NAD(+) <=> D-glucarate + 3 H(+) + NADH
REACT:R-HSA-2161619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGI2 is hydrolysed to 6k-PGF1a (Homo sapiens)
GO:0016890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	site-specific endodeoxyribonuclease activity, specific for altered base
GO:0016890	skos:prefLabel	"Site-specific endodeoxyribonucleases specific for altered bases"
GO:0016890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Site-specific endodeoxyribonucleases specific for altered bases"
GO:0016879	skos:prefLabel	"Forming carbon-nitrogen bonds"
GO:0016879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase activity, forming carbon-nitrogen bonds
GO:0016879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming carbon-nitrogen bonds"
GO:0016879	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	other carbon-nitrogen ligase activity
REACT:R-HSA-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Homo sapiens)
RHEA:67772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O = a 5'-end dephospho-ribonucleoside-RNA + phosphate
REACT:R-CFA-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Canis familiaris)
REACT:R-HSA-1592242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of NRF1 (Homo sapiens)
REACT:R-HSA-5362553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTUM releases Hh-Np:GPC5 from the plasma membrane (Homo sapiens)
RHEA:51206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => 6-trans-leukotriene B4 + NADP(+)
REACT:R-GGA-5323526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRAT proteins bind GSK3beta (Gallus gallus)
RHEA:70160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate(in) + H(+)(in) => folate(out) + H(+)(out)
REACT:R-DRE-5654677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR2 (Danio rerio)
RHEA:38448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O => 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose
RHEA:70802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(in) + L-ornithine(out) <=> L-lysine(out) + L-ornithine(in)
RHEA:50222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-demethyl-4-deoxygadusol => (S)-demethyl-4-deoxygadusol
RHEA:26325	skos:prefLabel	"5-pentadecatrienyl resorcinol O-methyltransferase"
RHEA:26325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-pentadecatrienyl resorcinol O-methyltransferase"
RHEA:26325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine
RHEA:65636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-(4E,8E)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine
REACT:R-DME-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Drosophila melanogaster)
REACT:R-DDI-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Dictyostelium discoideum)
REACT:R-DRE-1605768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Danio rerio)
REACT:R-DME-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Drosophila melanogaster)
RHEA:32880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R,5R)-5-hydroxycamphor + NAD(+) => (1R,4R)-bornane-2,5-dione + H(+) + NADH
REACT:R-RNO-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Rattus norvegicus)
REACT:R-MMU-381503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP6 binds IGF forming IGF:IGFBP6 (Mus musculus)
REACT:R-DRE-975147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Danio rerio)
REACT:R-MMU-4084982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Mus musculus)
REACT:R-CEL-390304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoASH (Caenorhabditis elegans)
RHEA:64707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphenylmethanol + NAD(+) <=> benzophenone + H(+) + NADH
RHEA:67651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + H2O <=> 2'-deoxyadenosine + H(+) + triphosphate
REACT:R-GGA-4551655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Gallus gallus)
REACT:R-GGA-2632521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Gallus gallus)
REACT:R-HSA-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Homo sapiens)
REACT:R-DRE-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Danio rerio)
RHEA:38213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA => hexadecane-1,2-diol + 2 hexadecanoyl-CoA
REACT:R-HSA-1236939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of exogenous soluble antigen with its corresponding receptor (Homo sapiens)
REACT:R-CFA-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Canis familiaris)
EC:1.3.1.5	skos:prefLabel	"cucurbitacin Delta(23)-reductase"
EC:1.3.1.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cucurbitacin Delta(23)-reductase"
REACT:R-MMU-4641246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 autoubiquitinates to promote its internalization (Mus musculus)
REACT:R-CEL-174374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
REACT:R-RNO-114263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization  of BAK at the mitochondrial membrane (Rattus norvegicus)
RHEA:48060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose
REACT:R-SSC-2467665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds Beta amyloid fibril via GAG chains (Sus scrofa)
RHEA:39557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH
RHEA:50046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+) => an acyl-CoA + H2O
RHEA:62093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate
RHEA:28125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + di-trans,octa-cis-undecaprenol <=> ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)
REACT:R-HSA-9759189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent PRDX1 gene expression (Homo sapiens)
REACT:R-XTR-1678716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(1) (Xenopus tropicalis)
REACT:R-SSC-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Sus scrofa)
RHEA:60094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4alpha-methylzymosterol + CO2 + NADH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+)
REACT:R-SSC-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)
REACT:R-BTA-2029465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)
REACT:R-BTA-392051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Grb2 to pFAK:NCAM1 (Bos taurus)
REACT:R-HSA-9686524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)
REACT:R-CEL-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Caenorhabditis elegans)
GO:0033704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-steroid dehydrogenase activity
GO:0033704	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity
RHEA:45724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + H(+) + NADPH
REACT:R-CFA-5357479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AXL binds PI3K (Canis familiaris)
RHEA:32570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (1R,4S)-camphene + diphosphate
REACT:R-HSA-9727297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA7 is translated to protein 7a (Homo sapiens)
REACT:R-BTA-350058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL NCOR corepressor complex (Bos taurus)
RHEA:55071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Gallus gallus)
RHEA:71754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + glutarate(in) <=> 2-oxoglutarate(in) + glutarate(out)
GO:0031769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucagon receptor binding
GO:0031769	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glucagon receptor ligand
REACT:R-SSC-8964340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq-BTK complex dissociates to Active BTK and Gq (Sus scrofa)
REACT:R-MMU-5218952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Mus musculus)
REACT:R-RNO-9018907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Rattus norvegicus)
REACT:R-SCE-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Saccharomyces cerevisiae)
RHEA:45811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate <=> (2S,3R)-dihydroxy-5-oxohexanedioate + H2O
RHEA:62279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine <=> 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-DRE-6799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates TP53 (Danio rerio)
REACT:R-SSC-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Sus scrofa)
RHEA:35214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIDP + H2O <=> dIMP + H(+) + phosphate
RHEA:43187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2843) in 25S rRNA <=> H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine
RHEA:41537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine
GO:0043919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine aminopropyltransferase activity
GO:0043919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine aminopropyl transferase activity
REACT:R-GGA-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Gallus gallus)
REACT:R-BTA-8964241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta-gamma complex and PIP3 recruit BTK to membrane (Bos taurus)
RHEA:50435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + prostaglandin G1 <=> A + H2O + prostaglandin H1
REACT:R-MMU-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Mus musculus)
RHEA:16308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA + H2O <=> 3-hydroxy-3-methylglutarate + CoA + H(+)
REACT:R-CEL-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Caenorhabditis elegans)
REACT:R-HSA-5218822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK binds BCAR1 and or PXN (Homo sapiens)
REACT:R-DRE-9700168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates IRS1 (Danio rerio)
REACT:R-CFA-1169398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host protein filamin B (Canis familiaris)
REACT:R-GGA-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Gallus gallus)
RHEA:21869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O => 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)
REACT:R-HSA-5685602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCR3LG1 binds NCR3 (Homo sapiens)
REACT:R-DME-4084989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Drosophila melanogaster)
REACT:R-BTA-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Bos taurus)
REACT:R-HSA-9624158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Substrate:LAMP2a:HSP90 polymerizes (Homo sapiens)
RHEA:38212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecane-1,2-diol + 2 hexadecanoyl-CoA => 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA
REACT:R-GGA-8866329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP lipidates APOB-100, forming a pre-VLDL (Gallus gallus)
REACT:R-BTA-9033491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Bos taurus)
REACT:R-HSA-9685830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUBB binds colchicine (Homo sapiens)
RHEA:63357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2
REACT:R-CEL-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Caenorhabditis elegans)
REACT:R-RNO-5686924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Rattus norvegicus)
RHEA:52197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:68357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-aspartyl-L-glutamate => L-glutamate + N-acetyl-L-aspartate
RHEA:18882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + histamine + L-glutamate => ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate
RHEA:61992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
REACT:R-HSA-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Homo sapiens)
REACT:R-DRE-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)
REACT:R-DRE-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Danio rerio)
REACT:R-DRE-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Danio rerio)
GO:1990837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence-specific double-stranded DNA binding
GO:1990837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence-specific dsDNA binding
REACT:R-HSA-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Homo sapiens)
REACT:R-CEL-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Caenorhabditis elegans)
GO:0015066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-amylase inhibitor activity
RHEA:54878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-isopropenyl-6-oxoheptanoate + H(+) => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one
GO:0009389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulphoxide reductase activity
GO:0009389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide reductase activity
RHEA:29610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + nitrous oxide <=> H(+) + NADH + 2 nitric oxide
GO:0001863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	collectin receptor activity
REACT:R-DRE-211881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A13 (Danio rerio)
REACT:R-SSC-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Sus scrofa)
REACT:R-BTA-9626928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP binds FOXO1 (Bos taurus)
RHEA:62710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(indol-3-yl)butanoyl-beta-D-glucose + UDP => (indol-3-yl)butanoate + UDP-alpha-D-glucose
REACT:R-CEL-5205681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is cleaved on healthy mitochondria (Caenorhabditis elegans)
RHEA:69436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxopregnenolone + H(+) + NADPH = 7beta-hydroxypregnenolone + NADP(+)
RHEA:67399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylglycineamide synthetase activity
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosylamine-glycine ligase activity
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycinamide ribonucleotide synthetase activity
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-phosphoribosylglycinamide synthetase activity
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GARS activity
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylglycinamide synthetase activity
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycineamide ribonucleotide synthetase activity
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GAR synthetase activity
GO:0004637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GAR
REACT:R-RNO-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Rattus norvegicus)
REACT:R-XTR-9625813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P binds S1PR3 in response to E2 stimulation (Xenopus tropicalis)
REACT:R-HSA-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Homo sapiens)
REACT:R-DRE-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Danio rerio)
REACT:R-DDI-211966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2D6 4-hydroxylates debrisoquine (Dictyostelium discoideum)
REACT:R-DME-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Drosophila melanogaster)
RHEA:64946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + 2 H(+) + 2 phosphate => dCTP + 2 H2O
REACT:R-XTR-193736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)
RHEA:61140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + myricetin + succinate
RHEA:44907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + H2O <=> alpha-D-glucose + phosphate
REACT:R-GGA-8954082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds the PRC1 complex (Gallus gallus)
RHEA:70814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate <=> D-xylulose 5-phosphate + sulfoacetaldehyde
REACT:R-XTR-192422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)
REACT:R-DRE-3788725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C complex binds EHMT1:EHMT2 (Danio rerio)
REACT:R-SSC-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Sus scrofa)
RHEA:49631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine
RHEA:29532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:47686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->2)-beta-D-glucosyl](n) + phosphate
REACT:R-XTR-2161907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Xenopus tropicalis)
RHEA:71082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] <=> cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0036463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tumor necrosis factor-related apoptosis-inducing ligand receptor
GO:0036463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL receptor activity
REACT:R-RNO-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Rattus norvegicus)
REACT:R-BTA-8855381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dephosphorylates ZAP70 (Bos taurus)
REACT:R-MMU-8871266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD3 (Mus musculus)
REACT:R-SPO-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Schizosaccharomyces pombe)
GO:0003735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of ribosome
GO:0003735	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribosomal protein
GO:0003735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribosomal RNA
REACT:R-CEL-1169406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host proteins (Caenorhabditis elegans)
RHEA:16992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate
REACT:R-CEL-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Caenorhabditis elegans)
RHEA:49938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-422051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the signal peptide of Preproghrelin (Bos taurus)
REACT:R-HSA-397891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)
RHEA:51286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
GO:0102182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity
REACT:R-DME-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Drosophila melanogaster)
REACT:R-RNO-5687088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates MAPKAPK5 (Rattus norvegicus)
REACT:R-HSA-166072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
REACT:R-HSA-380002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)
REACT:R-SSC-9605700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Sus scrofa)
REACT:R-CEL-2176491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L binds phosphorylated linker region of SMAD2/3 (Caenorhabditis elegans)
RHEA:49421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + valienone => ADP + H(+) + valienone 7-phosphate
RHEA:28728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(in) + H(+)(in) => Cu(2+)(out) + H(+)(out)
REACT:R-CFA-8878787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPI dimer hydrolyses phosphate monoesters (Canis familiaris)
RHEA:38475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine
REACT:R-XTR-174438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate on the C-strand (Xenopus tropicalis)
GO:0102459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-deoxyadenine diphosphate phosphatase activity
GO:0102459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dADP diphosphate phosphatase activity
REACT:R-HSA-400496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Signal peptidase hydrolyzes preproGIP to proGIP (Homo sapiens)
REACT:R-SCE-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Saccharomyces cerevisiae)
REACT:R-HSA-1655828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Lanosterol Synthase (LSS) (Homo sapiens)
RHEA:13883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + a quinol + H(+) => a quinone + an aldehyde + H2O
REACT:R-SSC-195251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the destruction complex (Sus scrofa)
GO:0090736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATH domain binding
REACT:R-CFA-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Canis familiaris)
RHEA:38621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside => nicotinate beta-D-ribonucleotide + phenol
RHEA:49767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylenediaminetriacetate + FMNH2 + O2 <=> ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O
RHEA:21689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a polyvinyl alcohol + n O2 => an oxidized polyvinyl alcohol + n H2O2
REACT:R-RNO-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)
REACT:R-BTA-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Bos taurus)
RHEA:70698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + glycine(out) + 3 Na(+)(out) <=> chloride(in) + glycine(in) + 3 Na(+)(in)
REACT:R-XTR-77303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Xenopus tropicalis)
RHEA:54850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + propyl propanoate => H(+) + hexan-3-one + NADPH + O2
RHEA:58260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] = ADP-D-ribose + L-tyrosyl-[protein]
REACT:R-DME-1307955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds HS:KLB:FGF19 (Drosophila melanogaster)
REACT:R-MTU-936615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylation of serine (Mycobacterium tuberculosis)
GO:0050114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketoinositol dehydratase activity
GO:0050114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O
GO:0050114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity
GO:0050114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inosose-2 dehydratase activity
GO:0050114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)
GO:0050114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosose 2,3-dehydratase activity
GO:0050114	skos:prefLabel	"myo-inosose-2 dehydratase"
GO:0050114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"myo-inosose-2 dehydratase"
REACT:R-CFA-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Canis familiaris)
REACT:R-SPO-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Schizosaccharomyces pombe)
REACT:R-XTR-5685953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates RBBP8 (Xenopus tropicalis)
EC:4.1.2.55	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase"
EC:4.1.2.55	skos:altLabel	"2-keto-3-deoxygluconate aldolase"
EC:4.1.2.55	skos:prefLabel	"2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase"
REACT:R-SSC-210282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GPVI and FceRI gamma (Sus scrofa)
REACT:R-MMU-1604712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP7 by trypsin (Mus musculus)
RHEA:59619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-L-arginine + H2O <=> beta-alanine + L-arginine
RHEA:10495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphocholine <=> choline + phosphate
GO:0061821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomeric Displacement-loop binding
GO:0061821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomeric D-loop binding
RHEA:17815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-tagaturonate + NADH => D-altronate + NAD(+)
REACT:R-HSA-5668629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Homo sapiens)
EC:3.4.25.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"HslU--HslV peptidase"
EC:3.4.25.2	skos:prefLabel	"HslU--HslV peptidase"
REACT:R-GGA-9018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds interacting proteins at the endosome membrane (Gallus gallus)
REACT:R-SSC-8855711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Sus scrofa)
RHEA:21200	skos:altLabel	"lysine epsilon-aminotransferase"
RHEA:21200	skos:prefLabel	"L-lysine 6-transaminase"
RHEA:21200	skos:altLabel	"L-lysine aminotransferase"
RHEA:21200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate
RHEA:21200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-lysine 6-transaminase"
RHEA:21200	skos:altLabel	"L-lysine transaminase"
REACT:R-SSC-1592297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full activation of MMP1 (Sus scrofa)
RHEA:50879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH <=> a hydroxy polyunsaturated fatty acid + H2O + NADP(+)
REACT:R-RNO-5671993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT-3 binds DLG4 (Rattus norvegicus)
REACT:R-HSA-5638009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
REACT:R-XTR-2468287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Xenopus tropicalis)
REACT:R-BTA-374909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabolism of Noradrenaline (Bos taurus)
RHEA:28448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose(out) => 1-deoxy-D-xylulose(in)
REACT:R-CFA-8853444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PHLDA1 (Canis familiaris)
REACT:R-RNO-205112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Rattus norvegicus)
RHEA:10440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gluconolactonase"
RHEA:10440	skos:altLabel	"lactonase"
RHEA:10440	skos:altLabel	"aldonolactonase"
RHEA:10440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone + H2O = D-gluconate + H(+)
RHEA:10440	skos:prefLabel	"gluconolactonase"
EC:3.4.21.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cucumisin"
EC:3.4.21.25	skos:prefLabel	"cucumisin"
RHEA:19755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) => ATP + diphthine-[translation elongation factor 2] + NH4(+)
REACT:R-HSA-69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk1 (Homo sapiens)
REACT:R-SSC-1650808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Sus scrofa)
RHEA:70224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + 2-oxoglutarate => 2-oxobutanoate + L-glutamate
RHEA:42846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide => 6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH
GO:0005247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated chloride channel activity
GO:0005247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage gated chloride channel activity
GO:0005247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Homo sapiens)
GO:0005247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent chloride channel activity
REACT:R-XTR-76456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-atom dealkylation of dextromethorphan (Xenopus tropicalis)
GO:0050546	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)
GO:0050546	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylpyruvate carboxy-lyase activity
GO:0050546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylpyruvate decarboxylase activity
REACT:R-DRE-205234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of GAB2 to p-KIT (Danio rerio)
REACT:R-MMU-210292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and TREM1 (Mus musculus)
REACT:R-PFA-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Plasmodium falciparum)
REACT:R-MMU-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Mus musculus)
REACT:R-DRE-9013108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOC (Danio rerio)
REACT:R-CEL-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Caenorhabditis elegans)
RHEA:71410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-1369017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in muscle cells (Drosophila melanogaster)
RHEA:64068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-phenylacetylcarbinol + NAD(+) = 1-phenyl-1,2-propanedione + H(+) + NADH
RHEA:40396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)
GO:0102001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoleucine N-monooxygenase (oxime forming) activity
REACT:R-DDI-71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Dictyostelium discoideum)
REACT:R-XTR-191999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Xenopus tropicalis)
REACT:R-BTA-75883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHRS7B reduces GO3P to HXDG3P (Bos taurus)
RHEA:26069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O => CoA + H(+) + phosphinomethylmalate
REACT:R-SSC-2471621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin degradation by cathepsins (Sus scrofa)
RHEA:35782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> mutildienyl diphosphate
RHEA:58234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein] => L-seryl-[protein] + NAD(+)
REACT:R-BTA-444879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 2 binds relaxin 2 and INSL3 (Bos taurus)
REACT:R-GGA-976801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I complex formation (Gallus gallus)
REACT:R-CEL-209815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is monoiodinated (Caenorhabditis elegans)
REACT:R-SSC-2247512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Sus scrofa)
RHEA:23970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + 2 H(+) + NADH => (E)-coniferaldehyde + H2O + NAD(+)
REACT:R-GGA-353494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by Pol kappa (Gallus gallus)
REACT:R-XTR-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Xenopus tropicalis)
RHEA:63862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,9Z,12Z)-2-hydroperoxyoctadecadienoate => (9Z,12Z)-octadecadienoate + O2
REACT:R-CFA-444171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR2 binds carboxylates (Canis familiaris)
RHEA:52574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + H(+) + NADH => butanoyl-CoA + NAD(+)
REACT:R-HSA-8950342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBI3:CANX binds IL27 (Homo sapiens)
RHEA:32173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetyl-CoA
RHEA:18719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine => 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine
RHEA:39243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)
REACT:R-DME-4570553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO2,3 (Drosophila melanogaster)
RHEA:59525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] => 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]
RHEA:67796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA
REACT:R-DRE-202714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD58 binds CD2 (Danio rerio)
REACT:R-RNO-114544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p115-RhoGEF activation of RHOA (Rattus norvegicus)
RHEA:39544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)
RHEA:43103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) <=> 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine
GO:0140868	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	4,4'-diapophytoene desaturase activity
GO:0140868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)
REACT:R-HSA-9026579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2 phosphorylates PLCG1 (Homo sapiens)
REACT:R-GGA-9617067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Gallus gallus)
REACT:R-RNO-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Rattus norvegicus)
GO:0015932	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity
GO:0015932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleobase-containing compound transmembrane transporter activity
REACT:R-DRE-9674131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 binds ATM dimer:Ub-p-PEX5 (Danio rerio)
REACT:R-HSA-445752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)
REACT:R-XTR-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Xenopus tropicalis)
REACT:R-MMU-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Mus musculus)
RHEA:58017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:30224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + hydrogen sulfide => 2 Fe(II)-[cytochrome c] + H(+) + sulfur
RHEA:21306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:53703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
REACT:R-XTR-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Xenopus tropicalis)
RHEA:68152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,3-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA
RHEA:51817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)
GO:0102975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	versiconal hemiacetal acetate reductase activity
RHEA:29494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> cis-muurola-4(14),5-diene + diphosphate
REACT:R-SSC-9709842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS binds TOMM70 (Sus scrofa)
RHEA:28214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha
REACT:R-DME-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Drosophila melanogaster)
EC:3.5.1.76	skos:prefLabel	"arylalkyl acylamidase"
EC:3.5.1.76	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arylalkyl acylamidase"
EC:3.5.1.76	skos:altLabel	"aralkyl acylamidase"
RHEA:17599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+) => D-mannitol + 2 Fe(III)-[cytochrome c]
RHEA:38763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
REACT:R-CFA-2160931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of tight junctions (Canis familiaris)
GO:0030735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine N-methyltransferase activity
GO:0030735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:carnosine N-methyltransferase activity
RHEA:54289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tyrosyl-[protein] => diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]
REACT:R-CEL-1606288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Caenorhabditis elegans)
RHEA:50464	skos:prefLabel	"(4-hydroxyphenyl)alkanoate synthase"
RHEA:50464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(4-hydroxyphenyl)alkanoate synthase"
RHEA:50464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH = 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)
RHEA:50464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH = 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)
REACT:R-CFA-5661124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR4-HIST1H4 (Canis familiaris)
RHEA:48435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-D-ribulosyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]
REACT:R-SSC-2214330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of collagen VII NC2 region by BMP1 (Sus scrofa)
RHEA:22244	skos:prefLabel	"kaempferol 3-O-xylosyltransferase"
RHEA:22244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kaempferol 3-O-xylosyltransferase"
RHEA:22244	skos:altLabel	"flavonol 3-O-xylosyltransferase"
RHEA:22244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + UDP-alpha-D-xylose = H(+) + kaempferol 3-O-beta-D-xyloside + UDP
REACT:R-BTA-5693564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with RAD52:DNA double-strand break ends (Bos taurus)
REACT:R-HSA-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Homo sapiens)
RHEA:59890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+) => 4-chloro-L-lysine + AH2 + O2
REACT:R-SPO-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Schizosaccharomyces pombe)
REACT:R-BTA-919404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT5 is released (Bos taurus)
RHEA:57801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dinitrotoluene + NADH + O2 => 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite
RHEA:13900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate <=> prephenate
GO:0140444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeleton-nuclear membrane anchor activity
GO:0140444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal protein-nuclear membrane adaptor activity
GO:0140444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal protein-nuclear membrane anchor activity
GO:0140444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeleton nuclear membrane anchor activity
GO:0140444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane-cytoskeleton anchor activity
GO:0005008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hepatocyte growth factor receptor activity
GO:0005008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF receptor activity
GO:0005008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF-activated receptor activity
GO:0005008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hepatocyte growth factor-activated receptor activity
REACT:R-HSA-2127562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRAP binds phosphorylated TGF-beta receptor complex (Homo sapiens)
REACT:R-BTA-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Bos taurus)
REACT:R-MMU-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Mus musculus)
REACT:R-MMU-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Mus musculus)
REACT:R-SSC-354073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PTK2 at Y397 (Sus scrofa)
RHEA:50410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-4(1H)-quinolone + H2O => 1-(2-aminophenyl)decane-1,3-dione
RHEA:12060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O
RHEA:17766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate => (2R)-2,3-bisphosphoglycerate + H(+)
RHEA:15454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + sarcosine => H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine
RHEA:64577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + NADPH => 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)
RHEA:14759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate => 2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone
REACT:R-CFA-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Canis familiaris)
RHEA:19626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine => acetaldehyde + glycine
REACT:R-XTR-2453876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTR:RBP:atROL binds to STRA6 receptor (Xenopus tropicalis)
REACT:R-DRE-8987097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Danio rerio)
RHEA:15691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + propane-1,3-diamine => H(+) + L-2,4-diaminobutanoate
REACT:R-BTA-389350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 by pVav1 (Bos taurus)
REACT:R-BTA-2327733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 binds Collagen types I-V, VII (Bos taurus)
REACT:R-HSA-9009227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)
REACT:R-GGA-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Gallus gallus)
REACT:R-MMU-429992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARN deadenylates mRNA (Mus musculus)
RHEA:42734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(527) in 16S rRNA + S-adenosyl-L-methionine
RHEA:65586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-5218818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Bos taurus)
REACT:R-CEL-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Caenorhabditis elegans)
REACT:R-MMU-9027633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Mus musculus)
REACT:R-HSA-975873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)
RHEA:65094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane G + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:57707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH
REACT:R-GGA-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Gallus gallus)
GO:0030741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol 3-O-methyltransferase activity
GO:0030741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol 3-O-methyltransferase activity
GO:0030741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity
GO:0030741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1-methyltransferase activity
GO:0030741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity
GO:0030741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)
GO:0030741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol D-1-methyltransferase activity
GO:0030741	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine:myo-inositol 3-methyltransferase activity
REACT:R-BTA-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
REACT:R-CFA-449073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-3 cleaves pro-interleukin-16 (Canis familiaris)
REACT:R-XTR-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Xenopus tropicalis)
REACT:R-CFA-2046084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Canis familiaris)
REACT:R-DRE-997237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B proteins bind JAK2 (Danio rerio)
RHEA:61282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NH4(+) + succinate semialdehyde => 4-aminobutanoate + H2O + O2
REACT:R-HSA-8950441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Homo sapiens)
RHEA:40908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-MMU-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Mus musculus)
GO:0045735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	storage protein of fat body
GO:0045735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nutrient reservoir activity
GO:0045735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	yolk protein
GO:0045735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	storage protein
RHEA:56959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITP + pyruvate <=> H(+) + IDP + phosphoenolpyruvate
RHEA:59521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoyl-CoA + hydrogencarbonate => (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate
REACT:R-MMU-1678944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Mus musculus)
RHEA:13223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + mevaldate + NADH => (R)-mevalonate + NAD(+)
REACT:R-RNO-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Rattus norvegicus)
GO:0047946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine N-acyltransferase activity
GO:0047946	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:L-glutamine N-acyltransferase activity
GO:0018792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(4-chlorophenyl)acetate decarboxylase activity
GO:0018792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDA decarboxylase activity
REACT:R-SSC-9661723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)
RHEA:59035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:42386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4'-diaponeurosporenoate + 2 H(+) + NADH => 4,4'-diaponeurosporenal + H2O + NAD(+)
RHEA:11249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O => (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)
REACT:R-CEL-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Caenorhabditis elegans)
REACT:R-CFA-6786072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3,p-Y641-STAT6 dissociate (Canis familiaris)
REACT:R-DRE-5672980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF complex (Danio rerio)
REACT:R-RNO-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Rattus norvegicus)
REACT:R-DRE-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Danio rerio)
RHEA:72472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + D-threo-isocitrate(in) => citrate(in) + D-threo-isocitrate(out)
RHEA:56117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-decaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)
REACT:R-CFA-5682598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates HERC2 (Canis familiaris)
REACT:R-HSA-2730899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BCL10 and MALT1 (Homo sapiens)
RHEA:55759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 <=> a 2-hydroxyornithine lipid + CO2 + succinate
REACT:R-HSA-2012087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 Y367C mutant (Homo sapiens)
RHEA:43369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-RNO-9645481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIFA oligomerization (Rattus norvegicus)
GO:0033715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside oxidase activity
GO:0033715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside:oxygen 5'-oxidoreductase activity
REACT:R-GGA-8874078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Gallus gallus)
REACT:R-DDI-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Dictyostelium discoideum)
RHEA:49524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA N(6)-methyladenine demethylase"
RHEA:49524	skos:prefLabel	"DNA N(6)-methyladenine demethylase"
RHEA:49524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate
GO:0019198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor protein phosphatase activity
REACT:R-XTR-352268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Satb1 (Xenopus tropicalis)
RHEA:33546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosteryl palmitate + H2O <=> ergosterol + H(+) + hexadecanoate
REACT:R-DRE-189384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)
REACT:R-XTR-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Xenopus tropicalis)
REACT:R-CFA-199154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD200 binds to CD200R (Canis familiaris)
REACT:R-MMU-1971491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Mus musculus)
REACT:R-MMU-9667563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR2 bind desmopressin (Mus musculus)
REACT:R-DME-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Drosophila melanogaster)
RHEA:18000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-2 + S-adenosyl-L-methionine <=> Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-5654672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR1 (Xenopus tropicalis)
RHEA:20629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
GO:0102155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-sulfolactate dehydrogenase activity
RHEA:44624	skos:altLabel	"dTDP-4-keto-2,6-dideoxy-D-glucose 3-oxidoreductase"
RHEA:44624	skos:prefLabel	"dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase"
RHEA:44624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH
RHEA:44624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase"
RHEA:44624	skos:altLabel	"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose 3-oxidoreductase"
REACT:R-RNO-5625870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Rattus norvegicus)
RHEA:22999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + L-ascorbate <=> 2 H2O + L-dehydroascorbate
REACT:R-DRE-445064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by VAV2 (Danio rerio)
RHEA:16380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0004534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' to 3' exoribonuclease hydrolyzes decapped mRNA (Homo sapiens)
GO:0004534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-3' exoribonuclease activity
EC:2.7.12.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dual-specificity kinase"
EC:2.7.12.1	skos:prefLabel	"dual-specificity kinase"
RHEA:62964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)
REACT:R-DRE-9674816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Danio rerio)
REACT:R-CFA-165777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4B by activated S6K1 (Canis familiaris)
REACT:R-DME-2032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ), TBX5, and PCAF form a complex (Drosophila melanogaster)
RHEA:19896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP <=> 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP
REACT:R-SSC-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Sus scrofa)
REACT:R-CFA-1306953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
REACT:R-DRE-432712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Danio rerio)
REACT:R-MMU-5610725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TULP3 is required for GPR161 localization in the cilium (Mus musculus)
REACT:R-HSA-110364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)
REACT:R-SPO-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Schizosaccharomyces pombe)
RHEA:40625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate => H2O + tritetradecanoylglycerol
RHEA:44953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H(+) + NADPH => NADP(+) + octanoyl-CoA
REACT:R-DME-8964246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in G alpha (12)-BTK complex is activated (Drosophila melanogaster)
REACT:R-BTA-2395257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-hydroxylysino-norleucine cross-links (Bos taurus)
RHEA:69627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-CFA-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Canis familiaris)
REACT:R-GGA-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Gallus gallus)
REACT:R-CFA-2186643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEN1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
REACT:R-MMU-1655842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P hydrolyzes SREBP1A,1C,2 (Mus musculus)
REACT:R-XTR-192056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Xenopus tropicalis)
REACT:R-SSC-389481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 1 receptor can bind orexin-A neuropeptide (Sus scrofa)
REACT:R-DRE-5638004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 binds ARL3:GTP:UNC119B (Danio rerio)
RHEA:53448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate
GO:0034955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxydiphenyl ether dioxygenase activity
REACT:R-BTA-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Bos taurus)
REACT:R-DDI-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Dictyostelium discoideum)
RHEA:54888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-OPC-8 + ATP + CoA = AMP + diphosphate + OPC8-CoA
REACT:R-DDI-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Dictyostelium discoideum)
RHEA:28853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose(out) + Na(+)(out) => melibiose(in) + Na(+)(in)
REACT:R-RNO-2179276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 monoubiquitinates SMAD3 (Rattus norvegicus)
RHEA:22276	skos:altLabel	"alpha-ketoaldehyde dehydrogenase"
RHEA:22276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoaldehyde dehydrogenase (NAD(+))"
RHEA:22276	skos:altLabel	"methylglyoxal dehydrogenase"
RHEA:22276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoaldehyde + H2O + NAD(+) = a 2-oxocarboxylate + 2 H(+) + NADH
RHEA:22276	skos:prefLabel	"2-oxoaldehyde dehydrogenase (NAD(+))"
RHEA:67869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-9761828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds the PGD gene (Homo sapiens)
REACT:R-GGA-416358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) inhibits PI3K alpha (Gallus gallus)
REACT:R-HSA-2484882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type X degradation by MMP3, 13 (Homo sapiens)
RHEA:44241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol
GO:0003841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-acylglycerophosphate acyltransferase activity
GO:0003841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophosphatidate acyltransferase activity
GO:0003841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-sn-glycerol-3-phosphate acyltransferase activity
GO:0003841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-acylglycerolphosphate acyltransferase activity
GO:0003841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysophosphatidic acid-acyltransferase activity
GO:0003841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0003841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-acyl-sn-glycerol 3-phosphate acyltransferase activity
GO:0003841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-acylglycero-3-phosphate acyltransferase activity
GO:0003841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-acyl-sn-glycero-3-phosphate acyltransferase activity
GO:0003841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity
REACT:R-DRE-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Danio rerio)
REACT:R-DME-6791219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Drosophila melanogaster)
REACT:R-HSA-9670412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs downstream of KIT mutants (Homo sapiens)
RHEA:57346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-D-kynurenine + S-adenosyl-L-methionine
RHEA:44229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-decenoate + ATP + CoA => 9-decenoyl-CoA + AMP + diphosphate
REACT:R-XTR-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Xenopus tropicalis)
REACT:R-SCE-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-XTR-8941623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
RHEA:43497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonate + NAD(+) => H(+) + keto-D-fructuronate + NADH
REACT:R-CFA-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Canis familiaris)
EC:3.4.24.75	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysostaphin"
EC:3.4.24.75	skos:altLabel	"glycyl-glycine endopeptidase"
EC:3.4.24.75	skos:prefLabel	"lysostaphin"
REACT:R-BTA-5620975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PIPs (Bos taurus)
RHEA:66584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocholestane + A + H2O = 25-hydroxy 3-oxocholestane + AH2
RHEA:19218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane => 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)
RHEA:60662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone + NAD(+) => 1,4-benzoquinone + H(+) + NADH
REACT:R-CFA-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Canis familiaris)
REACT:R-XTR-266310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:spherical HDL complex <=> LCAT + spherical HDL (Xenopus tropicalis)
REACT:R-CFA-4088218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetrastatin binds integrin alphaVbeta3 (Canis familiaris)
REACT:R-RNO-2395801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LAT by p-SYK (Rattus norvegicus)
RHEA:23007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP
RHEA:20921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorophenol + H(+) + NADPH + O2 => 3,5-dichlorocatechol + H2O + NADP(+)
REACT:R-DME-400183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA:RXRA binds Corepressors of PPARA (Drosophila melanogaster)
RHEA:25849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH
RHEA:23884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine
RHEA:23884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinamide N-methyltransferase"
RHEA:23884	skos:prefLabel	"nicotinamide N-methyltransferase"
REACT:R-HSA-9032054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LXA4/B4 translocate from cytosol to extracellular region (Homo sapiens)
REACT:R-GGA-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Gallus gallus)
REACT:R-MMU-204008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC31:SEC13 and v-SNARE recruitment (Mus musculus)
RHEA:40568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 => A + dTDP-beta-L-evernitrose + H2O
RHEA:55125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH => 5-methylhexanoyl-[ACP] + NAD(+)
RHEA:42138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine
RHEA:48684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine
RHEA:48684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[amino group carrier protein]-lysine hydrolase"
RHEA:48684	skos:prefLabel	"[amino group carrier protein]-lysine hydrolase"
REACT:R-DME-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Drosophila melanogaster)
REACT:R-SSC-77342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Sus scrofa)
REACT:R-CFA-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Canis familiaris)
RHEA:24380	skos:altLabel	"N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase"
RHEA:24380	skos:altLabel	"methionyl-transfer ribonucleate methyltransferase"
RHEA:24380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)
RHEA:24380	skos:altLabel	"methionyl-tRNA transformylase"
RHEA:24380	skos:altLabel	"methionyl-tRNA Met formyltransferase"
RHEA:24380	skos:prefLabel	"methionyl-tRNA formyltransferase"
RHEA:24380	skos:altLabel	"methionyl ribonucleic formyltransferase"
RHEA:24380	skos:altLabel	"formylmethionyl-transfer ribonucleic synthetase"
RHEA:24380	skos:altLabel	"methionyl-transfer ribonucleic transformylase"
RHEA:24380	skos:altLabel	"methionyl-transfer RNA transformylase"
RHEA:24380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionyl-tRNA formyltransferase"
REACT:R-HSA-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Homo sapiens)
REACT:R-XTR-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Xenopus tropicalis)
RHEA:39098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydecanedioyl-CoA + NAD(+) <=> 3-oxodecanedioyl-CoA + H(+) + NADH
GO:0050005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]
GO:0050005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity
GO:0050005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isohexenylglutaconyl-CoA hydratase activity
GO:0050005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity
GO:0050005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-isohexenylglutaconyl-CoA-hydratase activity
GO:0050005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isohexenylglutaconyl coenzyme A hydratase activity
RHEA:39511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA = (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O
RHEA:55999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
REACT:R-CFA-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)
RHEA:59967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-seryl-[protein]
REACT:R-HSA-5686578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates ABL1 (Homo sapiens)
REACT:R-DRE-9679740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA4:ITGB1 binds natalizumab (Danio rerio)
RHEA:39947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)
REACT:R-DME-432516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLK and CYC bind to form a heterodimer (Drosophila melanogaster)
RHEA:13435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + NH4(+) => 2'-deoxycytidine + H(+) + H2O
REACT:R-HSA-9763137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA2 binds SEM1 (DSS1) (Homo sapiens)
RHEA:61881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
REACT:R-RNO-5696945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates CCP110,ARRB (Rattus norvegicus)
REACT:R-MMU-9648949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A antagonists bind HTR3A pentamer (Mus musculus)
REACT:R-HSA-4570485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO3 (Homo sapiens)
REACT:R-BTA-983421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Journey of cargo through Golgi complex (Bos taurus)
REACT:R-SPO-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Schizosaccharomyces pombe)
RHEA:67801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate
REACT:R-SSC-9033527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Sus scrofa)
REACT:R-GGA-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)
REACT:R-HSA-9033509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5L (Homo sapiens)
RHEA:57007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + streptothricin D <=> CoA + H(+) + N(beta)-acetylstreptothricin D
RHEA:57664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + succinyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine
REACT:R-SSC-5635865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 dissociates from ub-PTCH1 (Sus scrofa)
REACT:R-DME-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Drosophila melanogaster)
REACT:R-SSC-2029476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Role of myosins in phagosome formation (Sus scrofa)
RHEA:72719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)
RHEA:56766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-epi-fischerindole G + CO2 + H2O + succinate => 12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2
RHEA:32967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine
RHEA:61313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Danio rerio)
REACT:R-BTA-5671772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T38-PPP1R14A binds MLCP (Bos taurus)
REACT:R-HSA-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
REACT:R-BTA-163798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein Z to protein Z (Bos taurus)
REACT:R-GGA-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Gallus gallus)
REACT:R-GGA-8866542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Gallus gallus)
RHEA:17195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O
GO:0051448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gonadotropin-releasing hormone binding
GO:0051448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GnRH binding
GO:0051448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gonadotrophin releasing hormone binding
REACT:R-GGA-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
REACT:R-BTA-5218891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomer binds MLKL (Bos taurus)
REACT:R-DME-8878787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPI dimer hydrolyses phosphate monoesters (Drosophila melanogaster)
REACT:R-DRE-9759209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2 binds extracellular TCN2:RCbl (Danio rerio)
REACT:R-SSC-419011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectins (Sus scrofa)
REACT:R-DRE-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Danio rerio)
RHEA:25973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(8)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine
REACT:R-HSA-2032775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD1 (Homo sapiens)
RHEA:72833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G[3'-5']pAp[3'] + H(+) => 3',3'-cGAMP + H2O
RHEA:62469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + ATP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + diphosphate
REACT:R-DRE-5626549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind CALM1 (Danio rerio)
REACT:R-XTR-2467794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of sister chromatids (Xenopus tropicalis)
RHEA:64300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropylamine + pyruvate = 3-phenylpropanal + L-alanine
REACT:R-RNO-5689111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 autoubiquitinates (Rattus norvegicus)
RHEA:24968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = H2O + 2 oxidized [adrenodoxin] + secalciferol
REACT:R-HSA-5218829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF induces CDC42 activation by unknown mechanism (Homo sapiens)
REACT:R-RNO-5638012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D dissociates from ARL13B:INPP5E (Rattus norvegicus)
REACT:R-DRE-193653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF homodimer binds to p75NTR (Danio rerio)
GO:0033974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside phosphoacylhydrolase activity
GO:0033974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside-5'-phosphoacylate acylhydrolase activity
REACT:R-XTR-444620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide S receptor binds neuropeptide S (Xenopus tropicalis)
RHEA:36051	skos:prefLabel	"non-reducing end beta-L-arabinofuranosidase"
RHEA:36051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"non-reducing end beta-L-arabinofuranosidase"
RHEA:36051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose
REACT:R-HSA-113705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Productive Transcription (Homo sapiens)
REACT:R-BTA-168921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIF:activated TLR3/TLR4 complex recruits RIP1 (Bos taurus)
RHEA:15675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + CoA + H(+) => acetoacetyl-CoA + H2O
REACT:R-DRE-8952807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dissociates after IL12:IL12R interaction (Danio rerio)
REACT:R-BTA-4755494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Bos taurus)
GO:0060002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	plus-end directed actin filament motor activity
GO:0060002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plus-end directed actin-filament motor activity
GO:0060002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plus-end directed microfilament motor activity
GO:0060002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	barbed-end directed actin-filament motor activity
GO:0140774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent protein depalmitoylase activity
GO:0140774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity
GO:0004671	skos:prefLabel	"protein-S-isoprenylcysteine O-methyltransferase"
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoprenylated protein methyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prenylcysteine carboxyl methyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prenylcysteine methyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesyl cysteine C-terminal methyltransferase activity
GO:0004671	skos:altLabel	"isoprenylcysteine carboxylmethyltransferase"
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prenylcysteine carboxymethyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesyl-protein carboxymethyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein S-farnesylcysteine C-terminal methyltransferase activity
GO:0004671	skos:altLabel	"prenylcysteine carboxyl methyltransferase"
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prenylated protein carboxyl methyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prenylated protein methyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoprenylcysteine carboxylmethyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-S-isoprenylcysteine O-methyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prenylcysteine carboxylmethyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-farnesylcysteine methyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine
GO:0004671	skos:altLabel	"prenylated protein carboxyl methyltransferase"
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-S-isoprenylcysteine O-methyltransferase"
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesylated protein C-terminal O-methyltransferase activity
GO:0004671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein C-terminal farnesylcysteine O-methyltransferase activity
GO:0034075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabidiol synthase activity
RHEA:70437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2
REACT:R-DRE-388832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds CD28 (Danio rerio)
RHEA:18891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + H(+) + UDP => D-glucose 6-phosphate + UDP-alpha-D-glucose
REACT:R-DME-209271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-HH moves from the cytosol to the extracellular region (Drosophila melanogaster)
RHEA:54185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-aromatic L-alpha-amino acid + H2O => a carboxylate + an aromatic L-alpha-amino acid
REACT:R-SSC-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)
REACT:R-BTA-8852354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)
REACT:R-HSA-8944099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PPARG binds PTEN gene promoter (Homo sapiens)
REACT:R-CFA-5626316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Canis familiaris)
REACT:R-CFA-1475032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Canis familiaris)
REACT:R-MMU-1433488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHP2 by SFKs (Mus musculus)
RHEA:27923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate
RHEA:15055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide
RHEA:52429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-leukotriene B4 + H(+) + NADH => 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)
RHEA:67407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Homo sapiens)
REACT:R-MMU-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Mus musculus)
REACT:R-MMU-5685156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2 (Mus musculus)
RHEA:33318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
GO:0032394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T cell receptor activity
GO:0032394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class Ib receptor activity
GO:0032394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-beta T cell receptor activity
GO:0032394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-delta T cell receptor activity
RHEA:66850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Cu(+) + H(+) + NAD(+) => 2 Cu(2+) + NADH
RHEA:41599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH <=> (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)
REACT:R-RNO-1497853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Rattus norvegicus)
REACT:R-BTA-2424485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-PLCG1 (Bos taurus)
REACT:R-DME-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Drosophila melanogaster)
RHEA:55678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + H2O => chorismate + NH4(+)
REACT:R-SPO-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Schizosaccharomyces pombe)
RHEA:34280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,poly-cis-dolichol + NADP(+) => di-trans,cis-polyprenol + H(+) + NADPH
RHEA:42179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-XTR-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Xenopus tropicalis)
RHEA:54395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:29259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate(out) + succinate(in) = (2R,3R)-tartrate(in) + succinate(out)
REACT:R-MMU-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Mus musculus)
RHEA:52142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+) => a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O
RHEA:31855	skos:prefLabel	"achilleol B synthase"
RHEA:31855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"achilleol B synthase"
RHEA:31855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = achilleol B
REACT:R-RNO-5635842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3 phosphorylates GLI (Rattus norvegicus)
REACT:R-GGA-376887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)
REACT:R-MMU-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Mus musculus)
RHEA:33296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Sus scrofa)
REACT:R-DDI-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Dictyostelium discoideum)
REACT:R-DME-8938913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF1 (Drosophila melanogaster)
REACT:R-SSC-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Sus scrofa)
REACT:R-RNO-1112602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Rattus norvegicus)
RHEA:54641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate => (12E)-labda-8(17),12,14-triene + diphosphate
REACT:R-CEL-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
REACT:R-SCE-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)
RHEA:50208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + NAD(+) = cortisone + H(+) + NADH
GO:0120048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U6 snRNA (adenine-(43)-N(6))-methyltransferase activity
REACT:R-HSA-9759332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2 binds the TXNRD1 promoter (Homo sapiens)
GO:0031220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltodextrin phosphorylase activity
REACT:R-MMU-8866329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP lipidates APOB-100, forming a pre-VLDL (Mus musculus)
GO:0035612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 adaptor complex binding
GO:0035612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AP-2 clathrin adaptor complex binding
REACT:R-RNO-2022919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Rattus norvegicus)
RHEA:23340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-oct-2-ulosonate = D-arabinose + pyruvate
RHEA:23340	skos:prefLabel	"3-deoxy-D-manno-octulosonate aldolase"
RHEA:23340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-D-manno-octulosonate aldolase"
RHEA:23340	skos:altLabel	"3-deoxy-D-manno-octulosonate D-arabinose-lyase"
RHEA:32128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-proline + O2 => cis-4-hydroxy-L-proline + CO2 + succinate
REACT:R-HSA-166215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA spontaneously flip-flops back to the matrix side (Homo sapiens)
RHEA:32603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-oxogeraniol + H(+) + NADPH
RHEA:60975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + NAD(+) <=> H(+) + hexanal + NADH
RHEA:13002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O => 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate
REACT:R-BTA-6801762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A oligomerize to form a pore complex (Bos taurus)
RHEA:40840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + nonanoyl-CoA => (2E)-nonenoyl-CoA + FADH2
REACT:R-HSA-8932955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Homo sapiens)
GO:0016668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor
GO:0016668	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0016668	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor
GO:0016668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor
GO:0016668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
GO:0016668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor
GO:0016668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
REACT:R-MMU-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Mus musculus)
REACT:R-SSC-2424480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
RHEA:33098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + inosine + phosphoenolpyruvate <=> futalosine
REACT:R-SSC-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Sus scrofa)
REACT:R-CFA-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Canis familiaris)
REACT:R-SSC-158982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Sus scrofa)
RHEA:14510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + mugineate + O2 => 3-epihydroxymugineate + CO2 + H(+) + succinate
RHEA:71060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-leucine(out) => L-arginine(out) + L-leucine(in)
RHEA:15948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]
RHEA:35524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-ethylmaleimide + NADPH => N-ethylsuccinimide + NADP(+)
REACT:R-SPO-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Schizosaccharomyces pombe)
REACT:R-SCE-5607721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NIK (Saccharomyces cerevisiae)
REACT:R-RNO-5696465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP45 deubiquitinates ERCC1 (Rattus norvegicus)
REACT:R-CEL-3000383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I, HDAC7 SUMOylate PML with SUMO1 (Caenorhabditis elegans)
RHEA:21713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-3-phenylserine => benzaldehyde + glycine
REACT:R-RNO-2161959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Rattus norvegicus)
RHEA:41678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + ATP
REACT:R-RNO-8940554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2 cleaves OPTC (Rattus norvegicus)
REACT:R-HSA-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Homo sapiens)
RHEA:35718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-versiconal hemiacetal acetate + H2O <=> (2S-3S)-versiconal hemiacetal + acetate + H(+)
REACT:R-DDI-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Dictyostelium discoideum)
REACT:R-HSA-5669158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF2 binds PAK1 (Homo sapiens)
RHEA:27433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione amide reductase"
RHEA:27433	skos:altLabel	"GAR"
RHEA:27433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione amide + NAD(+) = glutathione amide disulfide + H(+) + NADH
RHEA:27433	skos:prefLabel	"glutathione amide reductase"
RHEA:47926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + pyruvate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate
RHEA:67265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine => (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine
REACT:R-MMU-9660192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR agonists bind VDR (Mus musculus)
RHEA:32166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine
REACT:R-HSA-202375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ITK to SLP-76 (Homo sapiens)
RHEA:49886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-8940561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP7 cleaves OPTC (Homo sapiens)
REACT:R-BTA-432195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Bos taurus)
RHEA:12222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-leucine + NAD(+)
REACT:R-GGA-433101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Gallus gallus)
RHEA:46782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
EC:2.1.1.70	skos:prefLabel	"8-hydroxyfuranocoumarin 8-O-methyltransferase"
EC:2.1.1.70	skos:altLabel	"furanocoumarin 8-methyltransferase"
EC:2.1.1.70	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-hydroxyfuranocoumarin 8-O-methyltransferase"
EC:2.1.1.70	skos:altLabel	"furanocoumarin 8-O-methyl-transferase"
EC:2.1.1.70	skos:altLabel	"XMT"
EC:2.1.1.70	skos:altLabel	"xanthotoxol 8-O-methyltransferase"
RHEA:65647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine
REACT:R-CFA-194718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Canis familiaris)
REACT:R-DRE-9024997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Danio rerio)
REACT:R-RNO-446862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)
REACT:R-DME-3132753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pancreatic proteases degrade TCN1:RCbl (Drosophila melanogaster)
REACT:R-GGA-180047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates DARPP-32 on Thr75 (Gallus gallus)
RHEA:50059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycocholate(in) + H2O <=> ADP + glycocholate(out) + H(+) + phosphate
RHEA:71698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + L-alanyl-L-aspartate(out) <=> 2 H(+)(in) + L-alanyl-L-aspartate(in)
RHEA:46528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-193705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)
GO:0019789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO transferase activity
GO:0019789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SUMO conjugating enzyme activity
GO:0019789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SMT3 conjugating enzyme
GO:0047501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-neomenthol dehydrogenase activity
GO:0047501	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	monoterpenoid dehydrogenase activity
GO:0047501	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-neomenthol:NADP+ oxidoreductase activity
RHEA:41949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH
REACT:R-XTR-9009526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Xenopus tropicalis)
REACT:R-DRE-9027272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Danio rerio)
REACT:R-HSA-9693324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disulfiram covalently modifies Cys191 in GSDMD (Homo sapiens)
RHEA:41137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+) => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O
RHEA:49001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)
RHEA:37336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => 3-(carbamoylamino)-2-methylpropanoate + H(+)
REACT:R-DRE-8987042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Danio rerio)
RHEA:12213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-fluoren-9-ol + NADP(+) => 9H-fluoren-9-one + H(+) + NADPH
REACT:R-SSC-390281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Sus scrofa)
REACT:R-SSC-199203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK1/3/4 phosphorylate PanK (Sus scrofa)
REACT:R-XTR-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Xenopus tropicalis)
RHEA:67504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine
GO:0004939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-adrenergic receptor activity
GO:0004939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta adrenoceptor
RHEA:41886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP] => dodecanoyl-[ACP] + H(+) + malonyl-[ACP]
REACT:R-SSC-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Sus scrofa)
RHEA:54992	skos:prefLabel	"8-demethyl-8-aminoriboflavin-5'-phosphate synthase"
RHEA:54992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-demethyl-8-aminoriboflavin-5'-phosphate synthase"
RHEA:54992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + FMN + H2O + L-glutamate + O2 = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)
REACT:R-CFA-8939688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) complex binds RUNX2 (Canis familiaris)
REACT:R-PFA-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)
RHEA:54400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
RHEA:53564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + D-glucose 6-phosphate => ADP + alpha,alpha-trehalose 6-phosphate + H(+)
RHEA:39086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanedioyl-CoA + CoA <=> acetyl-CoA + decanedioyl-CoA
REACT:R-HSA-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Homo sapiens)
RHEA:55353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol => 13-cis-retinol
GO:0008009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine activity
REACT:R-BTA-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Bos taurus)
REACT:R-HSA-199558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR2DL1 interacting with HLA-C group 2 (Cw3) (Homo sapiens)
RHEA:63311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate
RHEA:23949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + NAD(+) => H(+) + NADH + succinate semialdehyde
REACT:R-BTA-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)
REACT:R-CEL-514604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Caenorhabditis elegans)
RHEA:22226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O => 3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA
RHEA:30514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinone-8 + H(+) + NADPH <=> 2-demethylmenaquinol-8 + NADP(+)
REACT:R-RNO-374723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nociceptin receptor binds to nociceptin (Rattus norvegicus)
GO:0018585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluorene oxygenase activity
RHEA:51263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + NAD(+) + nitrite => NADH + nitrobenzene + O2
REACT:R-HSA-9008577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37:IL18R1 binds SIGIRR (Homo sapiens)
RHEA:67428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)
REACT:R-GGA-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Gallus gallus)
REACT:R-SSC-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Sus scrofa)
RHEA:15827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AZD1979 oxetane hydrolysis product + H(+) => AZD1979 + H2O
RHEA:16914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)
EC:3.4.23.34	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin E"
EC:3.4.23.34	skos:altLabel	"slow-moving proteinase"
EC:3.4.23.34	skos:altLabel	"erythrocyte membrane aspartic proteinase"
EC:3.4.23.34	skos:prefLabel	"cathepsin E"
REACT:R-RNO-1855169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)
REACT:R-CFA-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Canis familiaris)
REACT:R-DME-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Drosophila melanogaster)
RHEA:24737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutanoate <=> (R)-2-hydroxyglutarate + succinate semialdehyde
RHEA:65292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + butan-2-one + 3 H2O + hydrogencarbonate = 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate
REACT:R-DRE-8857549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HBEGF-bound EGFR forms a heterodimer with GPNMB (Danio rerio)
REACT:R-SPO-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Schizosaccharomyces pombe)
RHEA:23614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-santonin + H(+) + NADH => 1,2-dihydro-alpha-santonin + NAD(+)
REACT:R-PFA-196950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTRAP hydrolyzes FMN to RIB (Plasmodium falciparum)
REACT:R-DRE-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Danio rerio)
REACT:R-RNO-2395784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent CMs transform into mature CMs (Rattus norvegicus)
REACT:R-RNO-179467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Rattus norvegicus)
RHEA:63351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-amino acyl-L-cysteinyl-[protein] <=> (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate
GO:0070040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (adenine-C2-)-methyltransferase activity
REACT:R-SSC-8851899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Sus scrofa)
REACT:R-SSC-6807052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBP isomerizes ZYMSTNL to LTHSOL (Sus scrofa)
REACT:R-DRE-5626988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds NSMAF (Danio rerio)
REACT:R-XTR-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Xenopus tropicalis)
REACT:R-DRE-8849891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-3 bind to PSD-95 family members (Danio rerio)
RHEA:66444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-3-one + NADP(+) = (E)-4-hexen-3-one + H(+) + NADPH
REACT:R-MMU-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Mus musculus)
RHEA:33114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> beta-copaene + diphosphate
REACT:R-GGA-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Gallus gallus)
RHEA:58656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine
REACT:R-XTR-1604360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP14 (Xenopus tropicalis)
REACT:R-BTA-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Bos taurus)
RHEA:34274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitroimidazole + H2O <=> 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite
RHEA:48561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate => D-ribose 5-phosphate + N(6)-dimethylallyladenine
REACT:R-CFA-2168881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Truncated Alpha-1-Microglobulin binds heme (Canis familiaris)
REACT:R-XTR-8983335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Xenopus tropicalis)
REACT:R-GGA-5635865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 dissociates from ub-PTCH1 (Gallus gallus)
RHEA:32845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol
REACT:R-RNO-3240957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PRC2-EZH2 complex (Rattus norvegicus)
REACT:R-RNO-9023968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Rattus norvegicus)
RHEA:53876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate
RHEA:47442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+)
RHEA:65724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + pentyl sulfate = CO2 + H(+) + pentanal + succinate + sulfate
REACT:R-RNO-416725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA6D binds to PLXNA1:TREM2:DAP12 (Rattus norvegicus)
REACT:R-MMU-5693549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Mus musculus)
RHEA:22088	skos:prefLabel	"GTP diphosphokinase"
RHEA:22088	skos:altLabel	"stringent factor"
RHEA:22088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GTP diphosphokinase"
RHEA:22088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate
RHEA:22088	skos:altLabel	"ppGpp synthetase I"
RHEA:22088	skos:altLabel	"guanosine 3',5'-polyphosphate synthase"
RHEA:22088	skos:altLabel	"GTP pyrophosphokinase"
GO:0034934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene-4-carboxylate dioxygenase activity
RHEA:53312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Homo sapiens)
RHEA:25152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-phenylalanine = 3-phenylpyruvate + L-glutamate
REACT:R-BTA-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)
RHEA:58995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamaldehyde + H2O + O2 <=> (E)-cinnamate + H(+) + H2O2
RHEA:22725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sterol + UDP-alpha-D-glucose => a sterol 3-beta-D-glucoside + H(+) + UDP
RHEA:52105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)
REACT:R-RNO-6814187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVL:PPL heterodimer binds the inner surface of the plasma membrane (Rattus norvegicus)
RHEA:30241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n a quinol + n sulfur => n a quinone + n H(+) + n hydrogen sulfide
REACT:R-RNO-8850961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREX2 binds PTEN and inhibits it (Rattus norvegicus)
RHEA:53904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L-threonyl-[tau protein]
GO:0043236	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	laminin-2 binding
GO:0043236	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	laminin-4 binding
GO:0043236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laminin binding
REACT:R-XTR-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Xenopus tropicalis)
RHEA:40820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-SPO-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Schizosaccharomyces pombe)
RHEA:33551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + H2O = a fatty acid + sphinganine
RHEA:64421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-proline(out) => H(+)(in) + L-alanyl-L-proline(in)
REACT:R-SSC-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Sus scrofa)
REACT:R-XTR-1236958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of particulate antigens with dendritic cell receptors (Xenopus tropicalis)
GO:0008819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobinamide kinase activity
REACT:R-BTA-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Bos taurus)
RHEA:41303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + dodecanoate
REACT:R-HSA-4093327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHA binds TIAM1 (Homo sapiens)
RHEA:18428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-quinate + NADP(+) <=> 3-dehydroquinate + H(+) + NADPH
GO:0031299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Tpa
GO:0031299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine-pyruvate aminotransferase activity
GO:0031299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurine:pyruvate aminotransferase activity
RHEA:68836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = (6R,7S)-himachala-9,11-diene + diphosphate
REACT:R-HSA-167234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Tat with P-TEFb(Cyclin T1:Cdk9) (Homo sapiens)
RHEA:66662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-glucosylceramide(out) + H(+) + phosphate => ATP + beta-D-glucosylceramide(in) + H2O
REACT:R-DRE-193736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Danio rerio)
RHEA:23677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
REACT:R-XTR-3928645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB:NMDAR binds TIAM1 (Xenopus tropicalis)
RHEA:50943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) <=> cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)
REACT:R-HSA-191972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)
RHEA:42607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)
REACT:R-SSC-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)
RHEA:52240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 Mn(2+) + O2 = 4 H(+) + 2 MnO2
RHEA:52240	skos:prefLabel	"manganese oxidase"
RHEA:52240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"manganese oxidase"
GO:0120301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lactyltransferase activity
REACT:R-SSC-6797913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARDH:FAD oxidatively demethylates SARC to Gly (Sus scrofa)
REACT:R-XTR-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Xenopus tropicalis)
RHEA:47417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an NDP-alpha-D-glucose + D-glucose => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)
RHEA:61149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP
REACT:R-GGA-9645406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Gallus gallus)
REACT:R-SSC-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Sus scrofa)
REACT:R-HSA-9646348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Homo sapiens)
REACT:R-BTA-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)
RHEA:66175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-cystine(out) <=> H(+)(in) + L-cystine(in)
REACT:R-BTA-5682769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI2 binds ADAM22,23 (Bos taurus)
RHEA:52249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 H2O + 4 Mn(3+) + O2 => 12 H(+) + 4 MnO2
REACT:R-SSC-8849900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs1-3 bind each other in cis interactions (Sus scrofa)
REACT:R-HSA-2752118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds Integrin alpha4beta1 (Homo sapiens)
REACT:R-CFA-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)
RHEA:39092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenedioyl-CoA + H2O => (3S)-hydroxydecanedioyl-CoA
RHEA:31484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol E + UDP-alpha-D-glucuronate => H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP
RHEA:58772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)
REACT:R-HSA-8961651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the PCNA gene promoter (Homo sapiens)
REACT:R-MMU-400071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Mus musculus)
REACT:R-GGA-5654730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Gallus gallus)
GO:0051108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine synthetase activity
GO:0051108	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	crotonobetaine/carnitine-CoA ligase activity
GO:0051108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine-CoA ligase activity
REACT:R-DRE-8956639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds YAP1 (Danio rerio)
REACT:R-DRE-4641206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPOs bind LGRs (Danio rerio)
REACT:R-RNO-374787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR neuropeptide receptor binds neuropeptides B and W (Rattus norvegicus)
REACT:R-RNO-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Rattus norvegicus)
REACT:R-DME-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Drosophila melanogaster)
REACT:R-MMU-163751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Mus musculus)
REACT:R-CEL-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Caenorhabditis elegans)
RHEA:24989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] => calcitroate + H2O + 2 oxidized [adrenodoxin]
RHEA:15488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-homoisocitrate <=> cis-homoaconitate + H2O
REACT:R-RNO-199219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Rattus norvegicus)
REACT:R-DME-9018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds interacting proteins at the endosome membrane (Drosophila melanogaster)
RHEA:64509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine
RHEA:29953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + uridine(out) => H(+)(in) + uridine(in)
RHEA:10818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fucose + methyl beta-D-galactoside => H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside
REACT:R-SSC-5683967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Sus scrofa)
REACT:R-PFA-5618328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAT acetylates microtubules (Plasmodium falciparum)
REACT:R-GGA-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Gallus gallus)
REACT:R-RNO-6803753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAAA hydrolyses NAEs to FAs and ethanolamine (Rattus norvegicus)
REACT:R-XTR-139970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO3:FAD N-oxidises TMA to TMAO (Xenopus tropicalis)
REACT:R-HSA-8987040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Homo sapiens)
REACT:R-BTA-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Bos taurus)
REACT:R-CFA-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Canis familiaris)
RHEA:35737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H(+) + NADPH => a (2R)-2-hydroxycarboxylate + NADP(+)
REACT:R-SCE-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Saccharomyces cerevisiae)
REACT:R-BTA-5218847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 binds NCK (Bos taurus)
REACT:R-SSC-4086392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Sus scrofa)
REACT:R-SSC-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Sus scrofa)
REACT:R-SSC-2105001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from DS (Sus scrofa)
RHEA:63927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(4)-acetylcytidine <=> ADP + H(+) + N(4)-acetylcytidine 5'-phosphate
GO:0015538	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialic acid permease activity
GO:0015538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialic acid:proton symporter activity
GO:0015538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialic acid:hydrogen symporter activity
GO:0015538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)
REACT:R-HSA-9696807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-glycan mannose trimming of Spike (Homo sapiens)
RHEA:27603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate => di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate
EC:3.4.11.19	skos:prefLabel	"D-stereospecific aminopeptidase"
EC:3.4.11.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-stereospecific aminopeptidase"
GO:0043862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine-agmatine antiporter activity
GO:0043862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine-agmatine exchange transporter activity
GO:0043862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine:agmatine antiporter activity
GO:0043862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AdiC
GO:0043862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine/agmatine antiporter activity
RHEA:70489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2
RHEA:48950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate
REACT:R-BTA-5654584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS bind to PPTN11 (Bos taurus)
RHEA:23941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH
REACT:R-HSA-5662986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds copper (Homo sapiens)
GO:0004612	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphopyruvate carboxykinase
GO:0004612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate carboxylase (ATP)
GO:0004612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:oxaloacetate carboxy-lyase (transphosphorylating)
GO:0004612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEPCK (ATP)
GO:0004612	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphoenolpyruvic carboxykinase
GO:0004612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate carboxykinase (ATP) activity
GO:0004612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEPK
GO:0004612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate carboxykinase (adenosine triphosphate)
GO:0004612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)
GO:0004612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate carboxylase (ATP)
RHEA:45461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-6799977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 hydrolyzes bacterial peptidoglycan (Canis familiaris)
RHEA:61900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + betaenone C = A + betaenone B
REACT:R-HSA-5689649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 (Homo sapiens)
RHEA:29188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate + ubiquinone-8 => fumarate + ubiquinol-8
REACT:R-DME-6799977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 hydrolyzes bacterial peptidoglycan (Drosophila melanogaster)
REACT:R-RNO-8855711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Rattus norvegicus)
RHEA:16844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-2 + S-adenosyl-L-methionine <=> H(+) + precorrin-3A + S-adenosyl-L-homocysteine
REACT:R-RNO-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Rattus norvegicus)
REACT:R-CFA-4608854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 are recruited to the DVL2:PARD6A complex (Canis familiaris)
REACT:R-CFA-934604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)
REACT:R-MMU-8874204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3 (Mus musculus)
RHEA:52698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose
REACT:R-HSA-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Homo sapiens)
REACT:R-DME-1855202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Drosophila melanogaster)
EC:3.1.7.3	skos:altLabel	"bornyl pyrophosphate hydrolase"
EC:3.1.7.3	skos:altLabel	"monoterpenyl-pyrophosphatase"
EC:3.1.7.3	skos:altLabel	"bornyl diphosphate hydrolase"
EC:3.1.7.3	skos:prefLabel	"monoterpenyl-diphosphatase"
EC:3.1.7.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monoterpenyl-diphosphatase"
RHEA:39771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-2247512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Gallus gallus)
RHEA:32140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + malonate => AMP + diphosphate + malonyl-CoA
GO:0008030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuronal pentaxin receptor
GO:0008030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuronal pentraxin receptor activity
REACT:R-CFA-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Canis familiaris)
REACT:R-DRE-5666001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Profilin:G-actin binds MKL1 (Danio rerio)
RHEA:71807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + NAD(+) = an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide
RHEA:65718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + CO2 + H(+) + succinate + sulfate => 2-oxoglutarate + a primary linear alkyl sulfate ester + O2
GO:0033401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UUU codon-amino acid adaptor activity
GO:0033401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine tRNA
GO:0033401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTT codon-amino acid adaptor activity
REACT:R-CFA-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Canis familiaris)
REACT:R-PFA-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Plasmodium falciparum)
REACT:R-MMU-6798373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates DYRK2 (Mus musculus)
REACT:R-BTA-1482776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Bos taurus)
REACT:R-GGA-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Gallus gallus)
REACT:R-PFA-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Plasmodium falciparum)
REACT:R-DRE-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Danio rerio)
RHEA:22624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate
RHEA:22624	skos:altLabel	"HOA"
RHEA:22624	skos:prefLabel	"4-hydroxy-2-oxovalerate aldolase"
RHEA:22624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-2-oxovalerate aldolase"
RHEA:22624	skos:altLabel	"4-hydroxy-2-oxovalerate pyruvate-lyase"
RHEA:22624	skos:altLabel	"4-hydroxy-2-oxopentanoate pyruvate-lyase"
RHEA:22624	skos:altLabel	"4-hydroxy-2-ketovalerate aldolase"
REACT:R-MMU-9793988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates CFLAR at K351, K353 (Mus musculus)
RHEA:21278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose + H(+) + NADPH => D-arabinitol + NADP(+)
REACT:R-CFA-5690759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Canis familiaris)
REACT:R-DDI-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Dictyostelium discoideum)
REACT:R-HSA-549467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CRYPTOCHROME-1 (Homo sapiens)
RHEA:12010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[G-protein-coupled receptor]-phosphate + ADP + H(+) => [G-protein-coupled receptor] + ATP
REACT:R-SCE-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Saccharomyces cerevisiae)
REACT:R-SSC-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Sus scrofa)
RHEA:70561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + N-acetyl-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O
RHEA:54891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-OPC-8 + ATP + CoA <=> AMP + diphosphate + OPC8-CoA
GO:0045549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NCED
GO:0045549	skos:altLabel	"nine-cis-epoxycarotenoid dioxygenase"
GO:0045549	skos:altLabel	"VP14"
GO:0045549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	9-cis-epoxycarotenoid 11,12-dioxygenase activity
GO:0045549	skos:altLabel	"NCED"
GO:0045549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"9-cis-epoxycarotenoid dioxygenase"
GO:0045549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PvNCED1
GO:0045549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neoxanthin cleavage enzyme
GO:0045549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nine-cis-epoxycarotenoid dioxygenase activity
GO:0045549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	VP14
GO:0045549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-epoxycarotenoid dioxygenase activity
GO:0045549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AtNCED3
GO:0045549	skos:prefLabel	"9-cis-epoxycarotenoid dioxygenase"
RHEA:33785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-kestotetraose + beta-D-glucose => 1(F)-beta-D-fructosylsucrose + sucrose
RHEA:71815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)
RHEA:11655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose <=> alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
RHEA:23640	skos:prefLabel	"aminocyclopropanecarboxylate oxidase"
RHEA:23640	skos:altLabel	"ACC oxidase"
RHEA:23640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate
RHEA:23640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminocyclopropanecarboxylate oxidase"
RHEA:23640	skos:altLabel	"ethylene-forming enzyme"
RHEA:23640	skos:altLabel	"1-aminocyclopropane-1-carboxylate oxidase"
REACT:R-SSC-446648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Sus scrofa)
RHEA:11840	skos:prefLabel	"benzaldehyde dehydrogenase (NAD(+))"
RHEA:11840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH
RHEA:11840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzaldehyde dehydrogenase (NAD(+))"
REACT:R-CEL-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)
RHEA:48656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Canis familiaris)
RHEA:65212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H2O = (2E)-dodecenoate + CoA + H(+)
RHEA:37632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:46445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-hexadecenoyl-CoA + AH2 + O2 => (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O
REACT:R-HSA-5336184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37L binds prosaposin (Homo sapiens)
REACT:R-XTR-1655831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 translocates to the nucleus (Xenopus tropicalis)
REACT:R-GGA-2186767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SKI/SKIL (Gallus gallus)
GO:0031370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF4G binding
GO:0031370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eukaryotic initiation factor 4G binding
REACT:R-SSC-1236940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exogenous soluble antigen targeted to more stable early endosome (Sus scrofa)
RHEA:29147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + nitrate + ubiquinol-8 = 2 H(+)(out) + H2O + nitrite + ubiquinone-8
REACT:R-DRE-5626982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF binds GNB2L1 (Danio rerio)
REACT:R-XTR-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Xenopus tropicalis)
REACT:R-CFA-202237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
REACT:R-CFA-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Canis familiaris)
REACT:R-DRE-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Danio rerio)
REACT:R-HSA-9027607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Homo sapiens)
REACT:R-HSA-8864999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFA gene expression is stimulated by the TFAP2A homodimer (Homo sapiens)
RHEA:32051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+)
RHEA:28537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP + H2O <=> diphosphate + dTMP + H(+)
RHEA:51755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4-prenylphloroglucinol + diphosphate
RHEA:72173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + taurohyocholate(in) => 2 Na(+)(out) + taurohyocholate(out)
RHEA:18601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,4-dihydroxyphthalate decarboxylase"
RHEA:18601	skos:prefLabel	"3,4-dihydroxyphthalate decarboxylase"
RHEA:18601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2
RHEA:18601	skos:altLabel	"3,4-dihydroxyphthalate carboxy-lyase"
REACT:R-DRE-947673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanin-concentrating hormone receptors bind MCH (Danio rerio)
REACT:R-GGA-6782106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates SNX3, CFTR (Gallus gallus)
REACT:R-HSA-209792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylation of serotonin (Homo sapiens)
GO:0106137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkappaB kinase complex binding
RHEA:35311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisoheptadecanoyl-CoA + NADP(+) = 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH
REACT:R-XTR-9036987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Xenopus tropicalis)
RHEA:34130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + olivetolate <=> cannabigerolate + diphosphate
REACT:R-DRE-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Danio rerio)
GO:0031885	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 member 2 taste receptor ligand
GO:0031885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 member 2 taste receptor binding
RHEA:71322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-cysteine(out) + 2 Na(+)(out) <=> chloride(in) + L-cysteine(in) + 2 Na(+)(in)
REACT:R-SSC-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Sus scrofa)
GO:0072548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity
RHEA:70699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)
EC:2.1.1.267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonoid 3',5'-methyltransferase"
EC:2.1.1.267	skos:prefLabel	"flavonoid 3',5'-methyltransferase"
REACT:R-CFA-2161282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastic fibres bind associated proteins (Canis familiaris)
REACT:R-HSA-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Homo sapiens)
REACT:R-MMU-5684169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6B binds PTPN6,PTPN11 (Mus musculus)
REACT:R-BTA-9645501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Bos taurus)
RHEA:39988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol => all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
RHEA:54189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-phenylalanine => acetate + L-phenylalanine
GO:0019862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgA binding
REACT:R-BTA-6806610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filament formation (Bos taurus)
GO:0019118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene-epoxide hydrolase activity
GO:0031995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin-like growth factor II binding
GO:0031995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF-II binding
RHEA:43192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine
RHEA:43192	skos:prefLabel	"tRNA:m(4)X modification enzyme"
RHEA:43192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA:m(4)X modification enzyme"
REACT:R-CFA-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Canis familiaris)
RHEA:69267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkanimidothioate <=> an isothiocyanate + sulfate
GO:0050303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine 6-dehydrogenase activity
GO:0050303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine 6-dehydrogenase activity
GO:0050303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LysDH activity
GO:0050303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine epsilon-dehydrogenase activity
GO:0050303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine:NAD+ 6-oxidoreductase (deaminating)
RHEA:63263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH <=> 4-pyridoxate + NAD(+)
RHEA:41074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-CEL-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Caenorhabditis elegans)
RHEA:69401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)2-lipid A + holo-[ACP]
RHEA:39034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP
RHEA:31794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tuberculosinyl diphosphate <=> (13S)-edaxadiene + diphosphate
GO:0050694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose 3-O-sulphotransferase activity
GO:0050694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose 3-O-sulfotransferase activity
GO:0050694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gal-3-O-sulfotransferase activity
REACT:R-RNO-373342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3CR1 binds CX3CL1 (Rattus norvegicus)
REACT:R-HSA-3257122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Homo sapiens)
REACT:R-SPO-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Schizosaccharomyces pombe)
RHEA:69231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkenimidothioate <=> an epithionitrile + sulfate
GO:0033772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavanone,NADPH:oxygen oxidoreductase activity
GO:0033772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	F3'5'H
GO:0033772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonoid 3',5'-hydroxylase activity
GO:0033772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	F3',5'H
REACT:R-MMU-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)
RHEA:26537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + AMP + diphosphate
REACT:R-DME-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)
REACT:R-CFA-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Canis familiaris)
REACT:R-HSA-158311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)
REACT:R-HSA-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Homo sapiens)
REACT:R-DME-350441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLW:MYPT-75D complex dephosphorylates SQH (Drosophila melanogaster)
REACT:R-RNO-400071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Rattus norvegicus)
REACT:R-RNO-9624272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMPs cleave HB-EGF (Rattus norvegicus)
REACT:R-XTR-193743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
REACT:R-DME-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Drosophila melanogaster)
REACT:R-BTA-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)
REACT:R-CFA-3371554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 acetylation at Lys80 (Canis familiaris)
GO:0047425	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HPC deaminase activity
GO:0047425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline-4-hydroxy-2-carboxylate deaminase activity
GO:0047425	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)
REACT:R-HSA-9009941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEL cleaves viral ssRNA (Homo sapiens)
RHEA:53066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxyestrone + UDP-alpha-D-glucuronate
REACT:R-BTA-389481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 1 receptor can bind orexin-A neuropeptide (Bos taurus)
RHEA:20801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-HSA-6802942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RHEA:38978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:17420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate
RHEA:15214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA => (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA
REACT:R-SSC-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Sus scrofa)
REACT:R-DRE-9670101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATRX:DAXX binds to subtelomeric chromosomal regions (Danio rerio)
RHEA:49762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O => EDTA + FMNH2 + O2
REACT:R-DME-72095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internal Methylation of mRNA (Drosophila melanogaster)
REACT:R-XTR-2424252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds collagen, fibronectin, aggrecan and matrilins (Xenopus tropicalis)
RHEA:62544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin = dihydroouabagenin + 2 Fe(III)-[cytochrome c]
RHEA:72923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III
REACT:R-HSA-192042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Homo sapiens)
REACT:R-GGA-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Gallus gallus)
REACT:R-SSC-4332356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK2 binds MAP3K7 (Sus scrofa)
RHEA:14705	skos:altLabel	"NADH:CoA-disulfide oxidoreductase"
RHEA:14705	skos:altLabel	"coenzyme A disulfide reductase"
RHEA:14705	skos:prefLabel	"CoA-disulfide reductase"
RHEA:14705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CoA + NADP(+) = CoA-disulfide + H(+) + NADPH
RHEA:14705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CoA-disulfide reductase"
RHEA:14705	skos:altLabel	"CoA-disulfide reductase [NAD(P)H]"
RHEA:14705	skos:altLabel	"CoADR"
REACT:R-SSC-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Sus scrofa)
RHEA:16700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinaldate <=> AH2 + kynurenate
REACT:R-MMU-8876472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 binds CHOL (Mus musculus)
REACT:R-RNO-446200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLPP1 dephosphorylates DOLDP to DOLP (Rattus norvegicus)
REACT:R-XTR-2025723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the N-glycan precursor (Xenopus tropicalis)
GO:0030946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine phosphatase activity, metal-dependent
RHEA:30952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => alpha-eudesmol + diphosphate
RHEA:63289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate
RHEA:35086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetylchitobiose-6'-phosphate + H2O <=> acetate + N'-monoacetylchitobiose-6'-phosphate
REACT:R-RNO-9648268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A antagonists (Rattus norvegicus)
REACT:R-CEL-377641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
RHEA:55034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N-methylornithine lipid + S-adenosyl-L-methionine
REACT:R-MMU-72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of eIF4E from the inactive eIF4E:4E-BP complex  (Mus musculus)
RHEA:40746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + 2 H2O <=> (20S)-ginsenoside C-K + 2 D-glucose
REACT:R-MMU-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Mus musculus)
REACT:R-BTA-9014641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Bos taurus)
RHEA:18142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + trans-cyclohexane-1,2-diol => 2-hydroxycyclohexan-1-one + H(+) + NADH
RHEA:34099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxynorspermidine + H(+) = CO2 + norspermidine
REACT:R-DME-6799777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind PPP1R13B or TP53BP2 (Drosophila melanogaster)
RHEA:45043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + hydroxylamine <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl
REACT:R-RNO-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Rattus norvegicus)
REACT:R-SPO-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Schizosaccharomyces pombe)
REACT:R-RNO-110353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MBD4 glycosylase by APEX1 at the AP site (Rattus norvegicus)
REACT:R-DDI-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)
RHEA:38269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylfumaryl-CoA => 2-methylfumaryl-CoA
REACT:R-HSA-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Homo sapiens)
REACT:R-DDI-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Dictyostelium discoideum)
REACT:R-RNO-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Rattus norvegicus)
REACT:R-CEL-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Caenorhabditis elegans)
RHEA:40251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-methylrhodomycin D + H2O = 10-carboxy-13-deoxydaunorubicin + H(+) + methanol
REACT:R-RNO-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Rattus norvegicus)
REACT:R-HSA-167019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)
RHEA:52550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-L-erythronate + H(+) + NADH => L-threonate + NAD(+)
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine:2-oxoglutarate aminotransferase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alanine transaminase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-alanine aminotransferase
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPT
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ALT
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Homo sapiens)
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-alanine aminotransferase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-alpha-ketoglutarate aminotransferase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic acid-pyruvic acid transaminase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic--alanine transaminase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-alanine transaminase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-glutamate transaminase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyruvate transaminase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic--pyruvic transaminase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-alanine aminotransferase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alanine aminotransferase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine-alpha-ketoglutarate aminotransferase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic-pyruvic aminotransferase activity
GO:0004021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-pyruvate aminotransferase activity
REACT:R-DRE-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Danio rerio)
RHEA:64176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-tryptophan = (9Z)-octadecenoate + L-tryptophan
REACT:R-HSA-9700998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 disrupts the BRCA1:BARD1 heterodimer (Homo sapiens)
REACT:R-CEL-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Caenorhabditis elegans)
RHEA:26114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
REACT:R-HSA-5687183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKDC phosphorylates DCLRE1C at DNA DSBs (Homo sapiens)
REACT:R-HSA-114259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase‑9 to caspase‑9 (Homo sapiens)
REACT:R-MMU-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Mus musculus)
REACT:R-BTA-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
RHEA:16103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate
RHEA:56781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5357928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLIP3 and CYLD bind TNF signaling complex (Bos taurus)
RHEA:62534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrodigitoxin + 2 Fe(III)-[cytochrome c] => digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+)
REACT:R-MMU-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Mus musculus)
REACT:R-RNO-198611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates IKKalpha (Rattus norvegicus)
RHEA:63699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SN-38 + UDP-alpha-D-glucuronate <=> H(+) + SN-38 O-beta-D-glucuronide + UDP
REACT:R-GGA-3371518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 binds to HSF1 (Gallus gallus)
REACT:R-BTA-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Bos taurus)
REACT:R-DRE-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)
REACT:R-HSA-425923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced (Homo sapiens)
RHEA:37823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate
REACT:R-DRE-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Danio rerio)
GO:0005280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid:proton symporter activity
GO:0005280	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cation/amino acid symporter
GO:0005280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Homo sapiens)
GO:0005280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen:amino acid symporter activity
RHEA:51004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + 2 Fe(III)-[cytochrome cL] = an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)
REACT:R-BTA-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Bos taurus)
REACT:R-DRE-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Danio rerio)
REACT:R-CFA-5625959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Canis familiaris)
RHEA:39887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin
REACT:R-HSA-71189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFMID hydrolyses NFK to L-KYN (Homo sapiens)
REACT:R-DDI-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)
RHEA:42372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-methoxytabersonine + H2O = (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine
RHEA:49207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
RHEA:33325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA
REACT:R-HSA-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)
RHEA:49863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Caenorhabditis elegans)
RHEA:46348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H2O = 3-hydroxyoctanoyl-CoA
RHEA:56004	skos:prefLabel	"endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase"
RHEA:56004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase"
RHEA:56004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)
RHEA:32103	skos:altLabel	"resveratrol O-methyltransferase"
RHEA:32103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-resveratrol di-O-methyltransferase"
RHEA:32103	skos:prefLabel	"trans-resveratrol di-O-methyltransferase"
RHEA:32103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + trans-resveratrol = 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine
RHEA:32103	skos:altLabel	"pterostilbene synthase"
REACT:R-MMU-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Mus musculus)
REACT:R-BTA-4719424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO1. (Bos taurus)
REACT:R-XTR-9667914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand midkine (MDK) (Xenopus tropicalis)
REACT:R-DRE-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Danio rerio)
GO:0018805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzylsuccinate fumarate-lyase activity
GO:0018805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzylsuccinate fumarate-lyase (toluene-forming)
GO:0018805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylsuccinate synthase activity
REACT:R-MMU-3238999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Mus musculus)
REACT:R-CEL-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Caenorhabditis elegans)
REACT:R-DRE-183067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Localization of CBL:GRB2 to the membrane (Danio rerio)
REACT:R-DRE-9658445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Danio rerio)
GO:0042283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity
GO:0042283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
RHEA:15609	skos:prefLabel	"ribose-phosphate diphosphokinase"
RHEA:15609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribose-phosphate diphosphokinase"
RHEA:15609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
RHEA:15609	skos:altLabel	"ribose-phosphate pyrophosphokinase"
RHEA:15609	skos:altLabel	"Phosphoribosyl pyrophosphate synthetase"
RHEA:15609	skos:altLabel	"Phosphoribosyl diphosphate synthetase"
REACT:R-HSA-5693575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PKcs autophosphorylates (Homo sapiens)
REACT:R-RNO-5654600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
REACT:R-XTR-1237045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Xenopus tropicalis)
REACT:R-RNO-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Rattus norvegicus)
REACT:R-HSA-2247511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2:ligand is endocytosed (Homo sapiens)
REACT:R-SSC-83677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4 deamination of cytidine (Sus scrofa)
RHEA:38437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol
REACT:R-BTA-5662608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds cadmium (Bos taurus)
REACT:R-DME-429699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 binds ceramide (Drosophila melanogaster)
RHEA:13336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 2,6-bisphosphate + H2O <=> beta-D-fructose 2-phosphate + phosphate
RHEA:10652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + H2O + NAD(+) = a long-chain fatty acid + 2 H(+) + NADH
RHEA:10652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-aldehyde dehydrogenase"
RHEA:10652	skos:prefLabel	"long-chain-aldehyde dehydrogenase"
REACT:R-CFA-446083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD151 interacts with BP180 and the integrin alpha 6 subunit (Canis familiaris)
REACT:R-SSC-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Sus scrofa)
RHEA:72633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(out) + 3 Li(+)(in) => Ca(2+)(in) + 3 Li(+)(out)
GO:0050301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	streptomycin-6-P phosphohydrolase activity
GO:0050301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	streptomycin 6-phosphate phosphatase activity
GO:0050301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	streptomycin-6-phosphatase activity
GO:0050301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	streptomycin 6-phosphate phosphohydrolase activity
GO:0050301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	streptomycin-6-phosphate phosphohydrolase activity
REACT:R-DRE-444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR5 binds CXCL13 (Danio rerio)
REACT:R-MMU-389762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PD-1 (Mus musculus)
REACT:R-RNO-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Rattus norvegicus)
REACT:R-HSA-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Homo sapiens)
REACT:R-BTA-5687183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKDC phosphorylates DCLRE1C at DNA DSBs (Bos taurus)
RHEA:37995	skos:prefLabel	"homogentisate solanesyltransferase"
RHEA:37995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homogentisate solanesyltransferase"
RHEA:37995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-nonaprenyl diphosphate + H(+) + homogentisate = 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate
RHEA:37995	skos:altLabel	"HST"
REACT:R-HSA-2022887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 N-deacetylates GlcNAc residues in heparan (Homo sapiens)
RHEA:66459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:30956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9'-di-cis-zeta-carotene + 2 a quinone => 7,7',9,9'-tetra-cis-lycopene + 2 a quinol
REACT:R-DME-6797961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHDH oxidises Cho to BETALD (Drosophila melanogaster)
RHEA:24900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-GMP + 2 diphosphate => 2 GTP
REACT:R-MMU-5624486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylates RAF1 on Y340,Y341 (Mus musculus)
RHEA:15292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose <=> [(1->4)-beta-D-xylan](n+1) + H(+) + UDP
RHEA:53050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxyestrone + UDP-alpha-D-glucuronate
REACT:R-DME-1254251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds YAP1 (Drosophila melanogaster)
REACT:R-SSC-389487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 2 receptor can bind orexin-B neuropeptide (Sus scrofa)
REACT:R-CFA-9653585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Farn-Me KRAS4B binds calmodulin (Canis familiaris)
REACT:R-BTA-548815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Bos taurus)
REACT:R-RNO-983218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B:RAD51C binds single-stranded DNA (Rattus norvegicus)
REACT:R-SCE-197268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)
RHEA:43504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethylfurfural + O2 = 2,5-diformylfuran + H2O2
REACT:R-BTA-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Bos taurus)
REACT:R-GGA-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Gallus gallus)
REACT:R-MMU-194310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Mus musculus)
REACT:R-HSA-5686924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Homo sapiens)
RHEA:37398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA
EC:3.4.11.6	skos:altLabel	"cytosol aminopeptidase IV"
EC:3.4.11.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminopeptidase B"
EC:3.4.11.6	skos:altLabel	"arginine aminopeptidase"
EC:3.4.11.6	skos:altLabel	"arginyl aminopeptidase"
EC:3.4.11.6	skos:prefLabel	"aminopeptidase B"
EC:3.4.11.6	skos:altLabel	"arylamidase II"
REACT:R-RNO-445753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Rattus norvegicus)
REACT:R-DRE-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Danio rerio)
RHEA:58971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthaldehyde + H2O + O2 <=> 1-naphthoate + H(+) + H2O2
RHEA:56112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)
REACT:R-BTA-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Bos taurus)
REACT:R-SSC-8851877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Sus scrofa)
REACT:R-DRE-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Danio rerio)
RHEA:61972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Mus musculus)
RHEA:28721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine(out) + H(+)(out) => adenine(in) + H(+)(in)
GO:0043765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	V.EcoKDcm
GO:0043765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	very short patch repair protein
GO:0043765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T/G mismatch-specific endonuclease activity
GO:0043765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Vsr mismatch endonuclease
GO:0043765	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA mismatch endonuclease
RHEA:43361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + UDP-alpha-D-glucose => an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP
REACT:R-MMU-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)
RHEA:69392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
REACT:R-CEL-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Caenorhabditis elegans)
GO:0140859	skos:altLabel	"7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase"
GO:0140859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxyisoflavanol 4,2'-dehydratase activity
GO:0140859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase activity
GO:0140859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pterocarpan synthase activity
GO:0140859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	medicarpan synthase activity
GO:0140859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pterocarpan synthase"
GO:0140859	skos:altLabel	"medicarpan synthase"
GO:0140859	skos:altLabel	"medicarpin synthase"
GO:0140859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol
GO:0140859	skos:altLabel	"2',7-dihydroxy-4'-methoxyisoflavanol dehydratase"
GO:0140859	skos:prefLabel	"pterocarpan synthase"
GO:0140859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	medicarpin synthase activity
GO:0140859	skos:altLabel	"2'-hydroxyisoflavanol 4,2'-dehydratase"
GO:0140859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',7-dihydroxy-4'-methoxyisoflavanol dehydratase activity
RHEA:52032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine-(+)-7-isojasmonate = (+)-7-isojasmonate + L-isoleucine
REACT:R-BTA-9020278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Bos taurus)
REACT:R-HSA-1791180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of IGFBP1 (Homo sapiens)
RHEA:20998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-2-oxohex-3-enedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O
REACT:R-CFA-9027628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises EPA to 5-HEPE (Canis familiaris)
REACT:R-DME-1008200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 binds the beta globin locus control region (Drosophila melanogaster)
RHEA:23935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-glucosamine 6-phosphate <=> an N-acyl-D-mannosamine 6-phosphate
REACT:R-GGA-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Gallus gallus)
REACT:R-GGA-1358795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitination of RNF41 by P-USP8 (Gallus gallus)
REACT:R-DRE-8862184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP48 cleaves polyubiquitin (Danio rerio)
RHEA:69283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate <=> 3-hydroxypropyl isothiocyanate + sulfate
RHEA:17239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + FAD => ATP + FMN + H(+)
RHEA:41283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoyl-sphing-4-enine = sphing-4-enine + tetracosanoate
RHEA:12191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) <=> (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2
RHEA:58233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]
REACT:R-SSC-202466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Bcl10 to CARMA1 (Sus scrofa)
RHEA:33302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-L-lysine + spermidine <=> [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
REACT:R-SSC-174967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT2 acetylation (Sus scrofa)
REACT:R-MMU-68918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
REACT:R-HSA-2327803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins bind Nidogens 1, 2 (Homo sapiens)
REACT:R-XTR-9703895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds CASR agonists (Xenopus tropicalis)
REACT:R-HSA-9735946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET small tyrosine kinase inhibitors bind MET (Homo sapiens)
REACT:R-GGA-1236955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Movement of clathrin coated vesicles into early endosome (Gallus gallus)
RHEA:54181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + holo-[ACP] + NAD(+) => a long-chain fatty acyl-[ACP] + H(+) + NADH
REACT:R-DRE-2022383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)
RHEA:20238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)
RHEA:62489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:25012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-982765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone forms dimers and oligomers (Sus scrofa)
REACT:R-CFA-2530501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTA:FNTB transfers FARN to GNGT1 (Canis familiaris)
REACT:R-XTR-109539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Xenopus tropicalis)
REACT:R-RNO-9693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds 5HT (Rattus norvegicus)
REACT:R-HSA-6797712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 stimulates expression of DNA repair genes (Homo sapiens)
REACT:R-BTA-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Bos taurus)
REACT:R-SPO-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Schizosaccharomyces pombe)
GO:0070636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinic acid ribonucleoside hydrolase activity
GO:0070636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinic acid riboside hydrolase activity
GO:0070636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribosylnicotinic acid hydrolase activity
GO:0070636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribosylnicotinate hydrolase activity
GO:0070636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate ribonucleoside hydrolase activity
GO:0070636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate riboside hydrolase activity
REACT:R-XTR-158721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Xenopus tropicalis)
RHEA:36651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-desmethylnovobiocic acid + S-adenosyl-L-methionine = H(+) + novobiocic acid + S-adenosyl-L-homocysteine
RHEA:36651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-demethylnovobiocic acid C(8)-methyltransferase"
RHEA:36651	skos:prefLabel	"8-demethylnovobiocic acid C(8)-methyltransferase"
RHEA:21771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methyl-L-alanine + NADP(+) <=> H(+) + methylamine + NADPH + pyruvate
REACT:R-HSA-212004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Homo sapiens)
RHEA:54447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3S,4S)-leucoanthocyanidin + NADP(+) <=> a (2R,3R)-dihydroflavonol + H(+) + NADPH
GO:0048248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR3 chemokine receptor binding
RHEA:63426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-lactyl-2-diphospho-5'-guanosine + diphosphate => (2S)-2-phospholactate + GTP + H(+)
REACT:R-HSA-8875482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)
GO:0009015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-N-succinyl-L-arginine iminohydrolase (decarboxylating)
GO:0009015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2-succinylarginine dihydrolase activity
GO:0009015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AstB
GO:0009015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2-succinyl-L-arginine iminohydrolase (decarboxylating)
GO:0009015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine succinylhydrolase activity
GO:0009015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AruB
GO:0009015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-succinylarginine dihydrolase activity
GO:0009015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SADH
GO:0009015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinylarginine dihydrolase activity
REACT:R-DME-5696945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates CCP110,ARRB (Drosophila melanogaster)
REACT:R-GGA-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Gallus gallus)
GO:0047962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine N-benzoyltransferase activity
GO:0047962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl-CoA:glycine N-acyltransferase activity
GO:0047962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl-CoA:glycine N-benzoyltransferase activity
GO:0047962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl CoA-amino acid N-acyltransferase activity
GO:0036143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kringle domain binding
RHEA:10834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O
RHEA:33772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)
REACT:R-DDI-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Dictyostelium discoideum)
RHEA:53355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20b) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20b) in tRNA
REACT:R-XTR-8941613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
REACT:R-CEL-193401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
REACT:R-RNO-5684836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC1B dimer binds PDPN (Rattus norvegicus)
REACT:R-HSA-140847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Homo sapiens)
REACT:R-MMU-176494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to 27HCHOL (Mus musculus)
RHEA:29915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
RHEA:33689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + taxol => 3'-N-debenzoyltaxol + benzoyl-CoA
REACT:R-GGA-8940554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2 cleaves OPTC (Gallus gallus)
REACT:R-RNO-8941234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Rattus norvegicus)
RHEA:16723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n) => 5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)
EC:3.1.21.8	skos:prefLabel	"T4 deoxyribonuclease II"
EC:3.1.21.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"T4 deoxyribonuclease II"
EC:3.1.21.8	skos:altLabel	"T4 endonuclease II"
GO:0042171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophosphatidic acid acyltransferase activity
GO:0042171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT activity
RHEA:23658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-cis,cis-muconate + H(+) => 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate
REACT:R-HSA-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Homo sapiens)
RHEA:70234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) <=> (S)-2-benzoylsuccinyl-CoA + H(+) + NADH
REACT:R-MMU-5693533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C (ARTEMIS) processes DNA DSB ends (Mus musculus)
REACT:R-DRE-158744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Danio rerio)
RHEA:62876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate = A + semiviriditoxin
REACT:R-DRE-6799761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds PPP1R13L (Danio rerio)
GO:0030020	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core matrisome
GO:0030020	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core extracellular matrix
GO:0030020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular matrix structural constituent conferring tensile strength
RHEA:21543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5-phospho-beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
REACT:R-MMU-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Mus musculus)
RHEA:61916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate
RHEA:18566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine => 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-420883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins act as GEFs for G alpha-t (Xenopus tropicalis)
REACT:R-SSC-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Sus scrofa)
RHEA:35244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + thiamine diphosphate => adenosine thiamine triphosphate + phosphate
REACT:R-BTA-1306957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
REACT:R-CFA-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Canis familiaris)
GO:0140407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine:proton antiporter activity
REACT:R-DRE-9018880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Danio rerio)
GO:0062054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoride channel activity
GO:0016830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-carbon lyase activity
GO:0016830	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	other carbon-carbon lyase activity
REACT:R-SCE-5692283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Saccharomyces cerevisiae)
REACT:R-DME-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Drosophila melanogaster)
REACT:R-CFA-5579018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1(868-1441) binds PAX3(1-319) (Canis familiaris)
REACT:R-HSA-9717395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPM5 transports Na+ from the extracellular region to the cytosol (Homo sapiens)
RHEA:21436	skos:prefLabel	"[elongation factor 2] kinase"
RHEA:21436	skos:altLabel	"eEF2 kinase"
RHEA:21436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)
RHEA:21436	skos:altLabel	"calmodulin-dependent protein kinase III"
RHEA:21436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[elongation factor 2] kinase"
RHEA:21436	skos:altLabel	"EF2K"
RHEA:21436	skos:altLabel	"CaM kinase III"
RHEA:21436	skos:altLabel	"Ca/CaM-kinase III"
RHEA:21436	skos:altLabel	"eEF2K"
REACT:R-SSC-420883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins act as GEFs for G alpha-t (Sus scrofa)
REACT:R-BTA-1237081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Bos taurus)
REACT:R-RNO-5678313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Rattus norvegicus)
RHEA:37442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
RHEA:44268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:36872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA
REACT:R-DDI-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Dictyostelium discoideum)
RHEA:29315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-galactose 1-phosphate phosphatase"
RHEA:29315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate
RHEA:29315	skos:prefLabel	"D-galactose 1-phosphate phosphatase"
RHEA:70831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out) + L-leucine(in) + Na(+)(in)
RHEA:56867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)
REACT:R-MMU-8852362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds CDKN1A (Mus musculus)
RHEA:13467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + N(3)-oxalyl-L-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + oxalyl-CoA
RHEA:49980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine
REACT:R-BTA-6807052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBP isomerizes ZYMSTNL to LTHSOL (Bos taurus)
REACT:R-XTR-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Xenopus tropicalis)
RHEA:40599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
RHEA:32347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tricin synthase"
RHEA:32347	skos:prefLabel	"tricin synthase"
RHEA:32347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + tricetin = 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:48250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0)
RHEA:71323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-asparagine(out) + 2 Na(+)(out) = chloride(in) + L-asparagine(in) + 2 Na(+)(in)
REACT:R-XTR-8957241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP73 tetramer translocates to the nucleus (Xenopus tropicalis)
REACT:R-RNO-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Rattus norvegicus)
REACT:R-HSA-8964465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DREAM complex binds the PCNA gene promoter (Homo sapiens)
RHEA:29787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O = ADP + glutathione(out) + H(+) + phosphate
RHEA:50785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + NADP(+) => (2E)-dodecenal + H(+) + NADPH
REACT:R-BTA-870477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Bos taurus)
REACT:R-HSA-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Homo sapiens)
REACT:R-DRE-3341343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Danio rerio)
REACT:R-GGA-9618021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXG1 binds FOXO:SMAD complexes (Gallus gallus)
REACT:R-SSC-352108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Sus scrofa)
REACT:R-MMU-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Mus musculus)
EC:1.1.1.405	skos:altLabel	"ribulose-5-P reductase"
EC:1.1.1.405	skos:altLabel	"D-ribulose 5-phosphate reductase"
EC:1.1.1.405	skos:altLabel	"ribulose-5-phosphate reductase"
EC:1.1.1.405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribitol-5-phosphate 2-dehydrogenase (NADP(+))"
EC:1.1.1.405	skos:prefLabel	"ribitol-5-phosphate 2-dehydrogenase (NADP(+))"
REACT:R-DRE-873922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 by JAK kinases (Danio rerio)
RHEA:29886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-ornithine(out) <=> ADP + H(+) + L-ornithine(in) + phosphate
RHEA:37279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-histidine(out) = ADP + H(+) + L-alanyl-L-histidine(in) + phosphate
REACT:R-SPO-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Schizosaccharomyces pombe)
REACT:R-HSA-9756661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EOMES and TBXT bind the SOX2 gene (Homo sapiens)
REACT:R-MMU-9749971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Mus musculus)
REACT:R-XTR-390304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoASH (Xenopus tropicalis)
REACT:R-DME-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Drosophila melanogaster)
REACT:R-CEL-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Caenorhabditis elegans)
RHEA:44563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-heptaprenyl diphosphate <=> 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate
RHEA:13573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate = [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP
RHEA:13573	skos:prefLabel	"polygalacturonate 4-alpha-galacturonosyltransferase"
RHEA:13573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polygalacturonate 4-alpha-galacturonosyltransferase"
RHEA:10084	skos:altLabel	"protocatechuate oxygenase"
RHEA:10084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate + 2 H(+)
RHEA:10084	skos:prefLabel	"protocatechuate 3,4-dioxygenase"
RHEA:10084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protocatechuate 3,4-dioxygenase"
RHEA:58871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
RHEA:66417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O => ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate
REACT:R-CEL-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Caenorhabditis elegans)
RHEA:64960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + H2O = dTMP + H(+) + phosphate
RHEA:35294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-methyldodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxoisopentadecanoyl-CoA + CO2 + CoA
REACT:R-CEL-5694126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)
RHEA:72379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + iodide(in) = chloride(in) + iodide(out)
REACT:R-BTA-9677585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Bos taurus)
REACT:R-RNO-6809810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Rattus norvegicus)
REACT:R-XTR-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Xenopus tropicalis)
RHEA:34362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + H2O <=> a 2-acylglycerol + a carboxylate + H(+)
RHEA:46828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH
REACT:R-SSC-2179387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Sus scrofa)
RHEA:44014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA
REACT:R-HSA-379395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates 3MT to HVA (Homo sapiens)
REACT:R-HSA-9638075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from DS (Homo sapiens)
RHEA:61706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-seryl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-serine
REACT:R-MMU-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Mus musculus)
RHEA:42589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
RHEA:42143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine
GO:0120019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine carrier activity
GO:0120019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine transfer activity
GO:0120019	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane phosphatidylcholine transfer activity
REACT:R-DME-8849350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Drosophila melanogaster)
RHEA:51833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)
RHEA:31247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prop-2-ynal + pyrroloquinoline quinol = prop-2-yn-1-ol + pyrroloquinoline quinone
RHEA:10786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2
REACT:R-HSA-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Homo sapiens)
RHEA:50179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate
REACT:R-XTR-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Xenopus tropicalis)
REACT:R-GGA-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Gallus gallus)
RHEA:23696	skos:altLabel	"meso-inositol oxygenase"
RHEA:23696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol oxygenase"
RHEA:23696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + O2 = D-glucuronate + H(+) + H2O
RHEA:23696	skos:altLabel	"MOO"
RHEA:23696	skos:prefLabel	"inositol oxygenase"
RHEA:23696	skos:altLabel	"myo-inositol oxygenase"
RHEA:22334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylmaleate + H2O => (3R)-citramalate
RHEA:72933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase]
RHEA:56037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)
RHEA:11878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin E2 + H(+) + NADH => NAD(+) + prostaglandin E2
REACT:R-HSA-2990842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)
REACT:R-SSC-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Sus scrofa)
REACT:R-CFA-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Canis familiaris)
RHEA:55989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
REACT:R-XTR-873922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 by JAK kinases (Xenopus tropicalis)
REACT:R-XTR-174122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Xenopus tropicalis)
RHEA:63577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone 22-phosphate + H2O => ecdysone + phosphate
REACT:R-XTR-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Xenopus tropicalis)
REACT:R-XTR-379426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Xenopus tropicalis)
RHEA:26422	skos:prefLabel	"thyroxine sulfotransferase"
RHEA:26422	skos:altLabel	"sulfotransferase 6B1"
RHEA:26422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate
RHEA:26422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thyroxine sulfotransferase"
RHEA:42112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-hydroxypregn-4-en-3-one + NADP(+) = H(+) + NADPH + progesterone
RHEA:30104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-didehydro-D-gluconate + H(+) + NADH => 5-dehydro-D-gluconate + NAD(+)
REACT:R-DRE-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Danio rerio)
RHEA:41748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)
REACT:R-MMU-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Mus musculus)
REACT:R-XTR-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Xenopus tropicalis)
RHEA:15504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADPH
RHEA:32203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"synephrine dehydratase"
RHEA:32203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-synephrine = (4-hydroxyphenyl)acetaldehyde + methylamine
RHEA:32203	skos:prefLabel	"synephrine dehydratase"
RHEA:45079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)
REACT:R-DRE-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Danio rerio)
RHEA:15584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biochanin A 7-O-beta-D-glucoside + malonyl-CoA <=> biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA
RHEA:22532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenedioyl-CoA + H2O = (3S)-hydroxyoctanedioyl-CoA
REACT:R-CFA-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
REACT:R-DRE-158340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Danio rerio)
RHEA:49280	skos:prefLabel	"phenol 2-monooxygenase (FADH2)"
RHEA:49280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 + phenol = catechol + FAD + H(+) + H2O
RHEA:49280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenol 2-monooxygenase (FADH2)"
REACT:R-BTA-167427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid dissociates from MOR (Bos taurus)
RHEA:51382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(9Z-octadecanoyl)-dopamine => (9Z)-octadecenoyl-CoA + dopamine
RHEA:69275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> allyl isothiocyanate + sulfate
REACT:R-XTR-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Xenopus tropicalis)
REACT:R-HSA-447219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RA and IL17RB bind IL25 dimer (Homo sapiens)
REACT:R-HSA-5668978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)
RHEA:30081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + crotonobetainyl-CoA + diphosphate => ATP + CoA + crotonobetaine
REACT:R-DRE-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Danio rerio)
RHEA:60650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine => an N-(acyl)-sphingosylphosphoethanolamine
REACT:R-BTA-982765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone forms dimers and oligomers (Bos taurus)
REACT:R-RNO-1889955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT dimers transfer GlcA to tetrasaccharide linker (Rattus norvegicus)
RHEA:62537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]
REACT:R-DME-3257122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Drosophila melanogaster)
REACT:R-HSA-2186771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 binds SMAD7 (Homo sapiens)
REACT:R-HSA-211959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A43 6b-hydroxylates TEST (Homo sapiens)
REACT:R-DRE-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Danio rerio)
RHEA:43576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate
RHEA:22171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose <=> UDP-alpha-D-galactose
REACT:R-DRE-158137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Danio rerio)
REACT:R-SSC-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Sus scrofa)
REACT:R-HSA-2393954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)
RHEA:26479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) => a 2-demethylmenaquinol + CO2 + diphosphate
GO:0102646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14betaH-scalarane-17alpha-19-diol synthase activity
RHEA:15071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H2O => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a
REACT:R-HSA-3204318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Homo sapiens)
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAM-A
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidylglycine monooxygenase activity
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide alpha-amidating enzyme
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyl alpha-amidating enzyme activity
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidylglycine alpha-hydroxylase activity
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	synthase, peptide alpha-amide
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAM-B
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAM activity
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide alpha-amide synthase activity
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide-alpha-amide synthetase activity
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidylglycine alpha-amidating monooxygenase activity
GO:0004504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidylglycine 2-hydroxylase activity
RHEA:42408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate + ATP = (2R)-2,3-bisphosphoglycerate + ADP + H(+)
RHEA:42408	skos:prefLabel	"2-phosphoglycerate kinase"
RHEA:42408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-phosphoglycerate kinase"
RHEA:56782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-448702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-1 active tetramer formation (Xenopus tropicalis)
REACT:R-SSC-141348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAO:FAD oxidises NASPM to PTCN (Sus scrofa)
REACT:R-BTA-9024334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Bos taurus)
REACT:R-HSA-5688884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CSF2RB does not bind SFTPs (Homo sapiens)
RHEA:69309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => phenylacetonitrile + sulfate + sulfur
REACT:R-BTA-9697750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8:FLIP(L) (Bos taurus)
RHEA:41162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)
REACT:R-MMU-112437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NELF complex  (Mus musculus)
RHEA:30893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + S-sulfo-L-cysteine => O-acetyl-L-serine + thiosulfate
RHEA:14782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + heptanedioate => 6-carboxyhexanoyl-CoA + AMP + diphosphate
REACT:R-BTA-8941623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
RHEA:53288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-scyllo-inosose + H2O = 5-dehydro-L-gluconate + H(+)
REACT:R-BTA-6806674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Bos taurus)
REACT:R-HSA-2424254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR transports extracellular CR:atREs to cytosol  (Homo sapiens)
EC:2.4.1.58	skos:prefLabel	"lipopolysaccharide glucosyltransferase I"
EC:2.4.1.58	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipopolysaccharide glucosyltransferase I"
REACT:R-DRE-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Danio rerio)
REACT:R-HSA-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Homo sapiens)
RHEA:30463	skos:prefLabel	"(+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]"
RHEA:30463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]"
RHEA:30463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate
GO:0140850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2B conserved C-terminal lysine ubiquitin ligase activity
GO:0140850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2B C-terminal K residue ubiquitin ligase activity
GO:0140850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone ubiquitin ligase activity (H2B-K120 specific)
GO:0140850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2BK120 ubiquitin ligase activity
GO:0140850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2B-K120 ubiquitin ligase activity
REACT:R-SSC-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Sus scrofa)
REACT:R-SSC-1604368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of bound proMMP2 (Sus scrofa)
REACT:R-SPO-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Schizosaccharomyces pombe)
REACT:R-RNO-1972385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-Ribosylation of HNP-1 (Rattus norvegicus)
RHEA:55300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
RHEA:60939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:22250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxykynurenate + H(+) + NADH => 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+)
REACT:R-SSC-5696997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP24 deubiquitinates DDB2 (Sus scrofa)
RHEA:66105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine
RHEA:11688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
RHEA:11688	skos:altLabel	"leucine translase"
RHEA:11688	skos:prefLabel	"leucine--tRNA ligase"
RHEA:11688	skos:altLabel	"leucyl-tRNA synthetase"
RHEA:11688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leucine--tRNA ligase"
RHEA:31128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-methylgallate + O2 => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol
REACT:R-RNO-202375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ITK to SLP-76 (Rattus norvegicus)
REACT:R-CFA-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Canis familiaris)
REACT:R-CFA-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Canis familiaris)
GO:0043732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxynicotinate hydroxylase activity
GO:0043732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate dehydrogenase activity
GO:0043732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxynicotinic acid dehydrogenase activity
GO:0043732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxynicotinate:O2 oxidoreductase activity
GO:0043732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxynicotinic acid hydroxylase activity
RHEA:42899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine
REACT:R-SSC-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Sus scrofa)
REACT:R-CFA-8854408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOBR dimer binds VLDLs (Canis familiaris)
REACT:R-DDI-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Dictyostelium discoideum)
RHEA:67800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate
REACT:R-DRE-5433067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Danio rerio)
REACT:R-CEL-391943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLT2 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)
REACT:R-GGA-9011981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 is recruited to MYC and BCL2 genes (Gallus gallus)
REACT:R-SPO-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Schizosaccharomyces pombe)
GO:0050619	skos:altLabel	"PPhiB synthase"
GO:0050619	skos:altLabel	"phytochromobilin synthase"
GO:0050619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytochromobilin:ferredoxin oxidoreductase activity
GO:0050619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPhiB synthase activity
GO:0050619	skos:altLabel	"PFB synthase"
GO:0050619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3Z)-phytochromobilin:ferredoxin oxidoreductase activity
GO:0050619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytochromobilin synthase activity
GO:0050619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phytochromobilin:ferredoxin oxidoreductase"
GO:0050619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P-Phi-B synthase activity
GO:0050619	skos:prefLabel	"phytochromobilin:ferredoxin oxidoreductase"
GO:0050619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PFB synthase activity
GO:0050619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HY2
GO:0050619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:31328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol => bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)
GO:0102535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ladanein 6-O-methyltransferase activity
RHEA:68043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lanthionine ketimine + 2 H(+) + NADPH <=> (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)
REACT:R-HSA-8848818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CBL (Homo sapiens)
REACT:R-BTA-450595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR:mRNA complex translocates from the nucleus to the cytosol (Bos taurus)
RHEA:40590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanedioyl-CoA <=> CoA + H(+) + octanedioate
RHEA:31620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate
RHEA:54486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine
REACT:R-DME-1861789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Drosophila melanogaster)
REACT:R-SSC-2454081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5 oxidises 11cROL to 11cRAL (Sus scrofa)
REACT:R-SSC-421416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proglucagon translocates from the ER Lumen to secretory granules (Sus scrofa)
GO:0035501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MH1 domain binding
GO:0035501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD homology 1 domain binding
REACT:R-HSA-194793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botC LC cleaves target cell SNAP25 (Homo sapiens)
REACT:R-BTA-1169402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of E2 conjugating enzymes (Bos taurus)
RHEA:52305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-ectoine => (2S)-2-acetamido-4-aminobutanoate
REACT:R-HSA-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Homo sapiens)
RHEA:28790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-threonine + ATP <=> 4-(phosphooxy)-L-threonine + ADP + H(+)
REACT:R-DRE-211239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with chromatin (Danio rerio)
REACT:R-MMU-5682769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI2 binds ADAM22,23 (Mus musculus)
REACT:R-MMU-166271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Mus musculus)
GO:0015173	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aromatic amino acid transporter activity
GO:0015173	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxy/aromatic amino acid permease activity
GO:0015173	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine/tyrosine/tryptophan permease activity
GO:0015173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic amino acid transmembrane transporter activity
REACT:R-CEL-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Caenorhabditis elegans)
REACT:R-RNO-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Rattus norvegicus)
REACT:R-CFA-5357776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
REACT:R-CFA-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)
RHEA:19871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylglycine + CoA + H(+) => an acyl-CoA + glycine
REACT:R-BTA-6810724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3 binds the bacterial surface (Bos taurus)
RHEA:47570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b (d18:1(4E)) + H(+) + UDP => ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose
RHEA:30964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,9,9'-tri-cis-neurosporene + a quinone => 7,7',9,9'-tetra-cis-lycopene + a quinol
GO:0106419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+) = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
GO:0106419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent protein lipoamidase activity
RHEA:33253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-kestotriose + beta-D-glucose => 2 sucrose
RHEA:16190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + O2 => CO2 + homogentisate
REACT:R-HSA-9619657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2 and SOX10 bind the PRX gene (Homo sapiens)
RHEA:59828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-inosyl-L-homocysteine = inosine + L-homocysteine
RHEA:59828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-inosyl-L-homocysteine hydrolase"
RHEA:59828	skos:prefLabel	"S-inosyl-L-homocysteine hydrolase"
RHEA:41279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoylsphing-4-enine = octadecanoate + sphing-4-enine
RHEA:53431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] <=> a thymidine in DNA + S-methyl-L-cysteinyl-[protein]
RHEA:37484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine => 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-BTA-162721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Bos taurus)
REACT:R-DDI-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Dictyostelium discoideum)
RHEA:19947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:69270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkenyl isothiocyanate + sulfate => a (Z)-N-(sulfonatooxy)alkenimidothioate
RHEA:63050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pravastatin => H2O + pravastatin lactone
REACT:R-XTR-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Xenopus tropicalis)
REACT:R-RNO-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Rattus norvegicus)
GO:0140463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin adaptor activity
GO:0140463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin-protein adaptor
GO:0140463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chromatin recruitment
GO:0140463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin receptor
GO:0140463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-chromatin adaptor activity
GO:0140463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin adaptor
GO:0140463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin-protein adaptor activity
REACT:R-MMU-4641256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated AXIN is degraded by the proteasome (Mus musculus)
REACT:R-HSA-1250383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Homo sapiens)
EC:1.7.1.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrite reductase (NADH)"
EC:1.7.1.15	skos:altLabel	"NADH-nitrite oxidoreductase"
EC:1.7.1.15	skos:altLabel	"assimilatory nitrite reductase"
EC:1.7.1.15	skos:prefLabel	"nitrite reductase (NADH)"
EC:1.7.1.15	skos:altLabel	"nitrite reductase (reduced nicotinamide adenine dinucleotide)"
REACT:R-MMU-9693324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disulfiram covalently modifies Cys191 in GSDMD (Mus musculus)
REACT:R-DRE-83582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Danio rerio)
REACT:R-HSA-380157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)
REACT:R-CFA-2090085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan chain(1) (Canis familiaris)
REACT:R-RNO-9674131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
RHEA:11997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2-ol + H(+) + NADH + O2 => biphenyl-2,3-diol + H2O + NAD(+)
RHEA:63805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-gulose => GDP-beta-L-galactose
RHEA:15215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA
REACT:R-CEL-2076611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3STs sulfate GlcN at C3 in heparan sulfate (Caenorhabditis elegans)
REACT:R-DDI-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
RHEA:35349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-CoA + H2O => 3-hydroxyoctadecanoyl-CoA
RHEA:36442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate
REACT:R-CFA-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
REACT:R-SCE-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Saccharomyces cerevisiae)
REACT:R-SSC-8876868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE1 cleaves EDN1(53-90) (Sus scrofa)
RHEA:40723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+)
REACT:R-DRE-9749647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES2 hydrolyzes ASA- (Danio rerio)
RHEA:25910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldose + H2O2 => an alditol + O2
GO:0030372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high molecular weight B-cell growth factor receptor binding
GO:0030372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high molecular weight B cell growth factor receptor binding
GO:0030372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high molecular weight B lymphocyte growth factor receptor binding
GO:0030372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high molecular weight B-lymphocyte growth factor receptor binding
GO:0030372	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	high molecular weight B cell growth factor receptor ligand
RHEA:43739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-BTA-193997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B1 oxidises 11DCORT (Bos taurus)
REACT:R-BTA-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Bos taurus)
RHEA:33996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-butirosin B => 5-oxo-L-proline + butirosin B
RHEA:29160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)
RHEA:63092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ilicicolin A + NADPH + O2 = H2O + ilicicolin A epoxide + NADP(+)
GO:0033417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUU codon-amino acid adaptor activity
GO:0033417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine tRNA
GO:0033417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTT codon-amino acid adaptor activity
REACT:R-CEL-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Caenorhabditis elegans)
REACT:R-HSA-9038653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHCE gene produces Rhesus C or E proteins (Homo sapiens)
REACT:R-XTR-430073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Xenopus tropicalis)
RHEA:50604	skos:prefLabel	"N-terminal methionine N(alpha)-acetyltransferase NatF"
RHEA:50604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-terminal methionine N(alpha)-acetyltransferase NatF"
RHEA:50604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]
REACT:R-DME-199299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO transcription factors (Drosophila melanogaster)
REACT:R-CFA-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Canis familiaris)
RHEA:61311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Rattus norvegicus)
REACT:R-CFA-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Canis familiaris)
GO:0052839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Homo sapiens)
GO:0052839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol diphosphate tetrakisphosphate kinase activity
GO:0052839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Homo sapiens)
RHEA:65478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + propyl butanoate => 1-propanol + butanoyl-CoA
RHEA:37552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-D-glucose 6-phosphate + L-glutamate => 2-oxoglutarate + D-kanosamine 6-phosphate
RHEA:72057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate(in) + 2 Na(+)(in) => glycodeoxycholate(out) + 2 Na(+)(out)
RHEA:20096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin + H(+) + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-beta-D-glucoside + UDP
REACT:R-CFA-8854303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D11 binds RAB6 (Canis familiaris)
RHEA:71412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) => 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)
RHEA:33407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + H(+) = diphosphate + glycyl-5'-AMP
REACT:R-CFA-8854612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)
RHEA:14427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP
REACT:R-DME-5628871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 promotes EP300-mediated acetylation of TP53 (Drosophila melanogaster)
GO:0020037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme binding
GO:0020037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	haem binding
REACT:R-SSC-209566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is auto-ubiquitinated (Sus scrofa)
RHEA:49336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dihydroxyspheroidene = H2O + spheroiden-2-one
REACT:R-CEL-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
REACT:R-XTR-6804276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TTC5 (Xenopus tropicalis)
RHEA:54885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + NADP(+) => H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
REACT:R-RNO-3215448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Rattus norvegicus)
REACT:R-MMU-72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of mRNA at the 3'-end (Mus musculus)
REACT:R-BTA-6809309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR6 binds MTMR9 (Bos taurus)
GO:0140665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone chaperone
GO:0140665	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H3-H4 histone complex loader activity
GO:0140665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3-H4 dimer loading activity
GO:0140665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-H4 dimer loading activity
GO:0140665	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H3-H4 histone chaperone
GO:0140665	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP-dependent H3-H4 histone complex loader activity
GO:0140665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent H3-H4 histone complex chaperone activity
REACT:R-MMU-190326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 (Mus musculus)
REACT:R-CFA-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Canis familiaris)
REACT:R-CFA-2161187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)
REACT:R-DRE-3927824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CASP8AP2 with SUMO1 (Danio rerio)
GO:0061651	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
GO:0061651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Atg12 conjugating enzyme activity
REACT:R-MMU-1296024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in neuroendocrine cells (Mus musculus)
RHEA:56593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a disubstituted aliphatic (S)-hydroxynitrile => a ketone + hydrogen cyanide
REACT:R-RNO-8850356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds microbial lipid-based antigen via CD1 (Rattus norvegicus)
GO:0050567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
GO:0050567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)
GO:0050567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamyl-tRNA(Gln) amidotransferase activity
GO:0050567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminyl-tRNA synthase (glutamine-hydrolysing)
GO:0050567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Glu-tRNAGln amidotransferase activity
GO:0050567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)
GO:0050567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Glu-tRNA(Gln) amidotransferase activity
GO:0050567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamyl-tRNAGln amidotransferase activity
GO:0050567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Glu-AdT activity
EC:3.4.21.92	skos:altLabel	"protease Ti"
EC:3.4.21.92	skos:altLabel	"caseinolytic protease"
EC:3.4.21.92	skos:altLabel	"endopeptidase Ti"
EC:3.4.21.92	skos:prefLabel	"endopeptidase Clp"
EC:3.4.21.92	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endopeptidase Clp"
RHEA:53543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine
RHEA:28198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-1-phenylethanol dehydrogenase"
RHEA:28198	skos:altLabel	"PED"
RHEA:28198	skos:prefLabel	"(S)-1-phenylethanol dehydrogenase"
RHEA:28198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH
REACT:R-RNO-377641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
GO:1990409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenomedullin binding
GO:1990409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AM binding
REACT:R-CEL-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Caenorhabditis elegans)
RHEA:32181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dipicolinate + H(+) + NADH => (S)-2,3-dihydrodipicolinate + NAD(+)
RHEA:37013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-RNO-1889978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALT6 transfers Gal to the tetrasaccharide linker (Rattus norvegicus)
GO:0047023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone dehydrogenase activity
GO:0047023	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3(or 17)alpha-hydroxysteroid dehydrogenase activity
GO:0047023	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3(or 17)-alpha-hydroxysteroid dehydrogenase activity
GO:0047023	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity
GO:0047023	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3(17)alpha-hydroxysteroid dehydrogenase activity
RHEA:72683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate(out) = cholate(in)
REACT:R-HSA-383313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)
REACT:R-GGA-9749609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCHE hydrolyzes ASA- (Gallus gallus)
REACT:R-BTA-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Bos taurus)
REACT:R-BTA-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Bos taurus)
GO:0033891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-CC-3'-preferring endodeoxyribonuclease activity
GO:0033891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity
GO:0033891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CC-preferring endodeoxyribonuclease activity
GO:0033891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Streptomyces glaucescens exocytoplasmic endonuclease activity
GO:0033891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity
REACT:R-CFA-383363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 2 (NK2) binds to nuerokinin A (Canis familiaris)
RHEA:47267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanoate + ATP + CoA <=> AMP + diphosphate + pristanoyl-CoA
REACT:R-HSA-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Homo sapiens)
REACT:R-CFA-380283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Canis familiaris)
RHEA:69240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucoraphanin + H2O = (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
RHEA:13239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine 6-phosphate + L-glutamate => D-fructose 6-phosphate + L-glutamine
RHEA:35430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside
RHEA:57072	skos:prefLabel	"3-oxoisoapionate-4-phosphate decarboxylase"
RHEA:57072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate 4-phosphate + H(+) = CO2 + L-erythrulose 1-phosphate
RHEA:57072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxoisoapionate-4-phosphate decarboxylase"
REACT:R-SSC-450173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 induces oligomerisation of TRAF6 (Sus scrofa)
REACT:R-SSC-74726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of insulin from insulin receptor (Sus scrofa)
REACT:R-GGA-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Gallus gallus)
RHEA:64856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + phomopsene
RHEA:54689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alliin => 2-aminoprop-2-enoate + allylsulfenate
RHEA:33686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine + octadecanoyl-CoA <=> 3-oxoeicosasphinganine + CO2 + CoA
RHEA:65941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + GDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)
RHEA:37951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate
RHEA:18911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trichloroanisole + S-adenosyl-L-homocysteine => 2,4,6-trichlorophenol + S-adenosyl-L-methionine
REACT:R-RNO-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Rattus norvegicus)
REACT:R-DDI-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Dictyostelium discoideum)
RHEA:68589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine => (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)
REACT:R-MMU-9033520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves TYSND1 (Mus musculus)
REACT:R-CFA-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Canis familiaris)
REACT:R-RNO-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Rattus norvegicus)
RHEA:19975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-methyl-5'-thioadenosine + spermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine
REACT:R-XTR-5625870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Xenopus tropicalis)
RHEA:34346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone
REACT:R-CFA-2730868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK7 by MEKK1 (Canis familiaris)
RHEA:65352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O
RHEA:51575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-3899291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of EP300 with SUMO1 (Mus musculus)
RHEA:58054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-acetamidoethyl)phosphonate + CoA + H(+) => (2-aminoethyl)phosphonate + acetyl-CoA
REACT:R-SSC-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Sus scrofa)
RHEA:60910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine
REACT:R-SSC-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Sus scrofa)
RHEA:53774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + lithocholate => chenodeoxycholate + lithocholoyl-CoA
REACT:R-SSC-265010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)
REACT:R-DME-2064417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-1 (TJP1) (Drosophila melanogaster)
REACT:R-DDI-936390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD mediated deubiquitination of DDX58 (RIG-I) (Dictyostelium discoideum)
RHEA:20082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methylhexanamide => hexanoate + methylamine
REACT:R-CFA-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Canis familiaris)
REACT:R-DRE-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Danio rerio)
REACT:R-SSC-9761344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 binds IKBKG within IKK complex (Sus scrofa)
REACT:R-DDI-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Dictyostelium discoideum)
RHEA:16599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CTP + 2 H(+) + phosphate => ATP + NH4(+) + UTP
RHEA:49979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine
RHEA:54842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + pentyl propanoate => H(+) + NADPH + O2 + octan-3-one
RHEA:37729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-CEL-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Caenorhabditis elegans)
RHEA:29264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(in) + Na(+)(in) => L-leucine(out) + Na(+)(out)
REACT:R-DRE-2066788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Danio rerio)
REACT:R-DRE-8941623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)
REACT:R-HSA-9008476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds GSK3B (Homo sapiens)
REACT:R-SSC-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Sus scrofa)
REACT:R-DDI-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Dictyostelium discoideum)
REACT:R-GGA-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Gallus gallus)
REACT:R-HSA-8987104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Homo sapiens)
REACT:R-MMU-187934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Mus musculus)
REACT:R-GGA-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Gallus gallus)
REACT:R-SSC-1011600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rabenosyn-5 connects  Rab5 to VPS-45 (Sus scrofa)
RHEA:24575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + sucrose <=> [(1->4)-alpha-D-glucosyl](n+1) + D-fructose
GO:0018570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + p-cumate = (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)
GO:0018570	skos:prefLabel	"p-cumate 2,3-dioxygenase"
GO:0018570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"p-cumate 2,3-dioxygenase"
GO:0018570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-cumate 2,3-dioxygenase activity
RHEA:21265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + glycolate => AH2 + glyoxylate
REACT:R-RNO-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Rattus norvegicus)
RHEA:59400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-aminohexanoate = D-2-aminohexanoate
RHEA:38410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)
REACT:R-DDI-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Dictyostelium discoideum)
REACT:R-HSA-9006325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO binds EPOR:JAK2:LYN:IRS2 (Homo sapiens)
REACT:R-CEL-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
REACT:R-GGA-8987161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Gallus gallus)
RHEA:59535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + S-adenosyl-L-methionine <=> (S)-codamine + H(+) + S-adenosyl-L-homocysteine
RHEA:59996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] = (E)-cinnamate + reduced [electron-transfer flavoprotein]
RHEA:30225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + H(+) + sulfur => 2 Fe(III)-[cytochrome c] + hydrogen sulfide
REACT:R-BTA-74948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates p-RHO to RHO (Bos taurus)
GO:0004757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydrobiopterin:NADP+ oxidoreductase activity
GO:0004757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sepiapterin reductase activity
REACT:R-DDI-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Dictyostelium discoideum)
REACT:R-PFA-9018895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Plasmodium falciparum)
RHEA:11652	skos:prefLabel	"undecaprenyl-phosphate galactose phosphotransferase"
RHEA:11652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"undecaprenyl-phosphate galactose phosphotransferase"
RHEA:11652	skos:altLabel	"poly(isoprenol)-phosphate galactosephosphotransferase"
RHEA:11652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose = alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
REACT:R-BTA-5607725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)
RHEA:43398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP
REACT:R-SCE-9018785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds GTP (Saccharomyces cerevisiae)
REACT:R-DRE-5617138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)
REACT:R-BTA-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Bos taurus)
RHEA:60285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-CFA-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Canis familiaris)
REACT:R-DDI-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Dictyostelium discoideum)
GO:2001227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercitrin binding
RHEA:59263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine
RHEA:28412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH => 4-(gamma-L-glutamylamino)butanal + H2O + NADP(+)
REACT:R-XTR-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Xenopus tropicalis)
GO:0036219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP diphosphohydrolase (diphosphate-forming); guanosine 5'-triphosphate pyrophosphohydrolase
GO:0036219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP diphosphohydrolase activity
GO:0036219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP diphosphatase activity
GO:0036219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP pyrophosphatase activity
RHEA:20104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + L-cysteinyl-[protein] <=> AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]
GO:0015355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monocarboxylate porter activity
GO:0015355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secondary active monocarboxylate transmembrane transporter activity
RHEA:69154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + spermidine => spermine monoaldehyde
EC:2.4.1.102	skos:prefLabel	"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase"
EC:2.4.1.102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase"
EC:2.4.1.102	skos:altLabel	"beta6-N-acetylglucosaminyltransferase"
EC:2.4.1.102	skos:altLabel	"O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I"
REACT:R-RNO-391941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLT receptors can bind LTB4 (Rattus norvegicus)
REACT:R-HSA-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Homo sapiens)
REACT:R-GGA-392295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma recruits PI3K gamma (Gallus gallus)
REACT:R-HSA-5615556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective POMT2 does not transfer Man from Dol-P-Man to DAG1 (Homo sapiens)
REACT:R-CFA-419003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Nectins with Afadin (Canis familiaris)
RHEA:33868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + glyoxylate => glycine + N-carbamoyl-2-oxoglycine
RHEA:36949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA
REACT:R-BTA-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Bos taurus)
REACT:R-BTA-3000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PLK1 (Bos taurus)
GO:0047014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
GO:0047014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate 1-dehydrogenase [NADP+] activity
GO:0047014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity
GO:0047014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glycerol 3-phosphate:NADP oxidoreductase activity
GO:0047014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerin-3-phosphate dehydrogenase activity
GO:0047014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent glycerin-3-phosphate dehydrogenase activity
RHEA:68115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propanamide <=> NH4(+) + propanoate
REACT:R-DRE-3222128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOC2L binds TP53 (Danio rerio)
REACT:R-DME-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)
RHEA:56466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O
RHEA:15371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-cis,cis-muconate + 2 H(+) => 2,3-dihydroxybenzoate + O2
RHEA:48876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine
RHEA:51918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + NH4(+) => (2S)-2-amino-3-butenoate + H2O
RHEA:14686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a primary alcohol => AH2 + an aldehyde
REACT:R-CFA-9020262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Canis familiaris)
RHEA:52503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:41556	skos:prefLabel	"[50S ribosomal protein L16]-arginine 3-hydroxylase"
RHEA:41556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[50S ribosomal protein L16]-arginine 3-hydroxylase"
RHEA:41556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate
RHEA:52024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = 18S-resolvin E2 + A + H2O
REACT:R-RNO-3791149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Rattus norvegicus)
REACT:R-DRE-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Danio rerio)
RHEA:59380	skos:prefLabel	"4-amino-4-deoxyprephenate dehydrogenase"
RHEA:59380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-amino-4-deoxyprephenate dehydrogenase"
RHEA:59380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxyprephenate + NAD(+) = 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH
REACT:R-HSA-9652165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)
REACT:R-BTA-6784006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Bos taurus)
REACT:R-DRE-432121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL binds to LRP8 (Danio rerio)
REACT:R-BTA-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Bos taurus)
REACT:R-SSC-976801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I complex formation (Sus scrofa)
REACT:R-MMU-1470009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs (Mus musculus)
REACT:R-GGA-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Gallus gallus)
REACT:R-SSC-873919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Sus scrofa)
REACT:R-BTA-388811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-1 homodimer (Bos taurus)
REACT:R-DRE-983138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC heterotrimer to ER exit site (Danio rerio)
REACT:R-HSA-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Homo sapiens)
EC:3.4.24.69	skos:altLabel	"botulinum neurotoxin"
EC:3.4.24.69	skos:prefLabel	"bontoxilysin"
EC:3.4.24.69	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bontoxilysin"
RHEA:61343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA
REACT:R-CFA-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Canis familiaris)
REACT:R-BTA-2404131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Bos taurus)
RHEA:48177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:51562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine => (S)-bulbocapnine + S-adenosyl-L-methionine
RHEA:35919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose = H(+) + kanamycin D + UDP
GO:0015526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexose-phosphate:inorganic phosphate antiporter activity
REACT:R-HSA-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Homo sapiens)
REACT:R-HSA-5694410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMED2:TMED10 tetramer binds GPI anchored proteins (Homo sapiens)
REACT:R-HSA-382553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA7:Apo1A-mediated phospholipid efflux (Homo sapiens)
RHEA:64923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate
RHEA:55143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)
REACT:R-CFA-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Canis familiaris)
RHEA:71871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxybutanoate(out) + H(+)(out) = (S)-3-hydroxybutanoate(in) + H(+)(in)
REACT:R-CEL-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Caenorhabditis elegans)
REACT:R-HSA-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Homo sapiens)
REACT:R-SSC-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Sus scrofa)
REACT:R-BTA-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Bos taurus)
RHEA:23888	skos:altLabel	"cyanophycin synthetase"
RHEA:23888	skos:prefLabel	"cyanophycin synthase (L-arginine-adding)"
RHEA:23888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanophycin synthase (L-arginine-adding)"
RHEA:23888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate
RHEA:23888	skos:altLabel	"multi-L-arginyl-poly-L-aspartate synthase"
REACT:R-SCE-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Saccharomyces cerevisiae)
REACT:R-SSC-450133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP binds MYD88 homodimer (Sus scrofa)
RHEA:16784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + H2O <=> a fatty acid + CoA + H(+)
REACT:R-CEL-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)
REACT:R-MMU-5666008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCAI binds SRF:MKL1 (Mus musculus)
REACT:R-XTR-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Xenopus tropicalis)
RHEA:33392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C20 sphinganine 1-phosphate + H2O => C20 sphinganine + phosphate
REACT:R-DRE-379048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
RHEA:51345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
REACT:R-MMU-3204311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOX1 oxidises PXL to PDXate (Mus musculus)
RHEA:29830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg(2+)(in) <=> Mg(2+)(out)
REACT:R-HSA-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Homo sapiens)
REACT:R-MMU-2396002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Mus musculus)
RHEA:29286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) + Na(+)(in) <=> L-alanine(out) + Na(+)(out)
REACT:R-DME-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Drosophila melanogaster)
RHEA:16734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + orsellinate => CO2 + orcinol
REACT:R-BTA-5672954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Bos taurus)
RHEA:70027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine
REACT:R-CEL-8878143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SMAD3 and SMAD4 (Caenorhabditis elegans)
RHEA:25904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"futalosine hydrolase"
RHEA:25904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	futalosine + H2O = dehypoxanthine futalosine + hypoxanthine
RHEA:25904	skos:altLabel	"futalosine nucleosidase"
RHEA:25904	skos:prefLabel	"futalosine hydrolase"
EC:4.1.1.-	skos:prefLabel	"Carboxy-lyases"
EC:4.1.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carboxy-lyases"
REACT:R-HSA-6796647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates CCNK expression (Homo sapiens)
REACT:R-DME-421007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of Ca impermeable AMPA receptors (Drosophila melanogaster)
REACT:R-HSA-9727288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7a localizes to the ERGIC membrane (Homo sapiens)
RHEA:42006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)
GO:0032566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGDP binding
REACT:R-BTA-202714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD58 binds CD2 (Bos taurus)
REACT:R-CEL-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Caenorhabditis elegans)
REACT:R-XTR-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)
RHEA:26559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O
RHEA:53350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NAD(+)
RHEA:10207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] <=> formaldehyde + methylamine + reduced [electron-transfer flavoprotein]
RHEA:24230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcatechol + CO2 + NADH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+)
REACT:R-RNO-8963851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 dissociates from GC (Rattus norvegicus)
RHEA:30239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n a quinone + n H(+) + n hydrogen sulfide = n a quinol + n sulfur
RHEA:30239	skos:prefLabel	"bacterial sulfide:quinone reductase"
RHEA:30239	skos:altLabel	"sulfide:quinone reductase"
RHEA:30239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacterial sulfide:quinone reductase"
REACT:R-MMU-199910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates ATF1 (Mus musculus)
REACT:R-SSC-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Sus scrofa)
RHEA:64877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP => H(+) + phosphate + UMP
REACT:R-RNO-8873794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCTP binds PC (Rattus norvegicus)
REACT:R-DRE-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Danio rerio)
REACT:R-CFA-1606602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Canis familiaris)
REACT:R-XTR-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Xenopus tropicalis)
GO:0047912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galacturonokinase (phosphorylating) D-galacturonic acid kinase activity
GO:0047912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galacturonokinase activity
GO:0047912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-galacturonate 1-phosphotransferase activity
REACT:R-SCE-9018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds interacting proteins at the endosome membrane (Saccharomyces cerevisiae)
REACT:R-DRE-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Danio rerio)
REACT:R-SSC-200318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Sus scrofa)
REACT:R-CFA-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Canis familiaris)
RHEA:35831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + kanamycin B + O2 = 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate
RHEA:35831	skos:prefLabel	"kanamycin B dioxygenase"
RHEA:35831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kanamycin B dioxygenase"
RHEA:40618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tridecanoylglycerol <=> 2,3-didecanoyl-sn-glycerol + decanoate + H(+)
REACT:R-DME-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Drosophila melanogaster)
REACT:R-XTR-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Xenopus tropicalis)
REACT:R-BTA-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin N-deacetylase/N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparan sulfate N-deacetylase/N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparitin N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosaminyl N-deacetylase/N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin N-deacetylase/N-sulphotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS:N-desulfoheparin sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-desulfoheparin sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparitin sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparan sulphate]-glucosamine N-sulphotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparitin N-sulphotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparan sulfate 2-N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desulfoheparin sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-HSST activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-heparan sulfate sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparan sulfate N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparin-glucosamine N-sulfotransferase activity
GO:0015016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS:DSH sulfotransferase activity
GO:0047104	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexadecanal:NAD+ oxidoreductase (CoA-acylating)
GO:0047104	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fatty acyl-CoA reductase activity
GO:0047104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanal dehydrogenase (acylating) activity
RHEA:39823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CFA-8854071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)
RHEA:54923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + NADP(+) <=> 13-cis-retinal + H(+) + NADPH
REACT:R-MMU-983707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates at the activated BCR (Mus musculus)
REACT:R-CEL-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Caenorhabditis elegans)
RHEA:34015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 = ergosterol + 2 H2O + NADP(+)
REACT:R-DME-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Drosophila melanogaster)
RHEA:42055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol + NAD(+) <=> 9-cis-retinal + H(+) + NADH
REACT:R-MMU-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Mus musculus)
RHEA:69048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexano-6-lactone = 6-hydroxyhexanoate + H(+)
RHEA:72049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + fusahexin + 6 H2O => A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline
RHEA:40285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-hexadecanedioyl-L-carnitine => (R)-carnitine + hexadecanedioyl-CoA
RHEA:44065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + octan-1-ol => CoA + octyl hexadecanoyl
REACT:R-XTR-379464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DOPAC to form HVA (Xenopus tropicalis)
REACT:R-HSA-9027633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Homo sapiens)
REACT:R-MMU-8942099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Mus musculus)
REACT:R-HSA-351849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Etk (Homo sapiens)
REACT:R-MMU-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Mus musculus)
GO:0102371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betulin dehydrogenase activity
REACT:R-SPO-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Schizosaccharomyces pombe)
REACT:R-SPO-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Schizosaccharomyces pombe)
RHEA:45798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + H(+) + NADPH => (3R)-3-hydroxybutanoyl-CoA + NADP(+)
REACT:R-RNO-391155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRPA binds SFTPA oligomer, SFTPD oligomer (Rattus norvegicus)
REACT:R-HSA-6794345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLGNs binds PSD-95 subfamily members (Homo sapiens)
RHEA:42355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-nicotine + A + H2O <=> (R)-6-hydroxynicotine + AH2
RHEA:71157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + H(+) + pyruvate => (E)-caffeoylpyruvate + H2O
REACT:R-MMU-6801675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates NPM1 (Mus musculus)
GO:0034854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-3-oxopentanoate decarboxylase activity
RHEA:59027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trihexadecanoylglycerol <=> dihexadecanoylglycerol + H(+) + hexadecanoate
REACT:R-DRE-964759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alternative endo-mannosidase I route (Danio rerio)
REACT:R-PFA-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Plasmodium falciparum)
REACT:R-GGA-110221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by SMUG1 glycosylase (Gallus gallus)
REACT:R-GGA-5218822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK binds BCAR1 and or PXN (Gallus gallus)
RHEA:12326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine + N-acetyl-D-glucosamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine
RHEA:72868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-cAAG + H2O => A[3'-5']pG[3'-5']pAp[3'] + H(+)
REACT:R-RNO-417927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y2 receptor binds ATP and UTP (Rattus norvegicus)
REACT:R-XTR-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)
REACT:R-CEL-4093336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
REACT:R-BTA-5635860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Bos taurus)
REACT:R-CFA-8948219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3 binds Lysyl hydroxylated collagen propeptides (Canis familiaris)
REACT:R-PFA-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Plasmodium falciparum)
REACT:R-MMU-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Mus musculus)
REACT:R-BTA-5693609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53 at S15 (Bos taurus)
REACT:R-XTR-1475026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (cytosol) (Xenopus tropicalis)
GO:1904121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylethanolamine carrier activity
GO:1904121	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylethanolamine transporter activity
GO:1904121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylethanolamine transfer activity
GO:1904121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane phosphatidylethanolamine transfer activity
RHEA:38961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-CoA + H2O2 => a 2,3-saturated acyl-CoA + O2
RHEA:60161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + vincristine(in) => ADP + H(+) + phosphate + vincristine(out)
REACT:R-CEL-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Caenorhabditis elegans)
REACT:R-HSA-8877003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLL1 ubiqutinates the InlA-bound CDH1 complex (Homo sapiens)
REACT:R-DDI-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Dictyostelium discoideum)
REACT:R-DRE-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Danio rerio)
REACT:R-RNO-8950405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Rattus norvegicus)
RHEA:55674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine
RHEA:47878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + N-acetylneuraminate => ganglioside GD1b + H2O
RHEA:40026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate + H2O <=> diphosphate + syn-copalol
RHEA:31901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase] => indole + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:60776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A12 + O2 = CO2 + gibberellin A15 + succinate
RHEA:27643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + phosphate => adenine + alpha-D-ribose 1-phosphate
RHEA:33388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine => aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine
RHEA:24371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine <=> L-proline + NH4(+)
REACT:R-HSA-2213200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of endostatin-like peptides (Homo sapiens)
REACT:R-MMU-451895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RG binds JAK3 (Mus musculus)
REACT:R-HSA-9694373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)
REACT:R-RNO-8936584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)
RHEA:63453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized 3PG-factor420-0
REACT:R-CEL-8849082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)
RHEA:61314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DDI-76054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Dictyostelium discoideum)
RHEA:38898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)
RHEA:47264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanoate + ATP + CoA = AMP + diphosphate + pristanoyl-CoA
GO:0015045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rubredoxin-NAD(P)+ reductase activity
GO:0015045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity
GO:0015045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH:rubredoxin reductase activity
GO:0015045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)--rubredoxin oxidoreductase activity
GO:0015045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H--rubredoxin oxidoreductase activity
GO:0015045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rubredoxin:NAD(P)+ oxidoreductase activity
GO:0015045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rubredoxin--nicotinamide adenine activity
GO:0015045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dinucleotide phosphate reductase activity
REACT:R-GGA-8964604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Gallus gallus)
REACT:R-MMU-5684801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y7-CLEC1B dimer:PDPN binds SYK (Mus musculus)
RHEA:59484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arsenate reductase (cytochrome c)"
RHEA:59484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite + 2 Fe(III)-[cytochrome c] + H2O = arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)
RHEA:59484	skos:altLabel	"arsenite oxidase"
RHEA:59484	skos:prefLabel	"arsenate reductase (cytochrome c)"
REACT:R-BTA-1676164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)
REACT:R-CFA-209840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two DITs combine to form thyroxine (Canis familiaris)
REACT:R-BTA-2162002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Bos taurus)
RHEA:53102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine
GO:0140399	skos:prefLabel	"aflatoxin B synthase"
GO:0140399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aflatoxin B synthase"
GO:0140399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aflatoxin B synthase activity
REACT:R-HSA-5601897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events (Homo sapiens)
REACT:R-RNO-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Rattus norvegicus)
REACT:R-HSA-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Homo sapiens)
REACT:R-HSA-6799197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
REACT:R-RNO-8878143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SMAD3 and SMAD4 (Rattus norvegicus)
REACT:R-BTA-350158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGMN degrades GC (Bos taurus)
GO:0050157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine racemase activity
GO:0102357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mithramycin dehydrogenase activity
RHEA:48310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-6-oxohex-3-enoyl-CoA + formate + H(+) => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O
RHEA:66341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate
RHEA:67648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + H2O = 2'-deoxyadenosine + H(+) + triphosphate
REACT:R-DRE-2453833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Danio rerio)
REACT:R-SSC-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Sus scrofa)
GO:0070401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP (oxidized) binding
GO:0070401	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP binding
GO:0070401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP+ binding
GO:0070401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized NADP binding
GO:0070401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized nicotinamide adenine dinucleotide phosphate binding
RHEA:10451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a flavanone + O2 <=> a flavone + CO2 + H2O + succinate
REACT:R-MMU-199202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphopantetheine conjugation of the ACP domain of FAS (Mus musculus)
GO:0062058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription factor TFIIH holo complex binding
REACT:R-GGA-5687094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 phosphorylate MAPKAPK5 (Gallus gallus)
REACT:R-MMU-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Mus musculus)
REACT:R-CEL-380949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK is dephosphorylated (Caenorhabditis elegans)
REACT:R-HSA-9022942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAD2 gene expression is stimulated by MECP2 (Homo sapiens)
REACT:R-CEL-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Caenorhabditis elegans)
RHEA:69031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrotestosterone + H(+) + NADPH <=> 5beta-androstane-3alpha,17beta-diol + NADP(+)
GO:0046873	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	low affinity metal ion uptake transporter activity
GO:0046873	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heavy metal ion porter activity
GO:0046873	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	high affinity metal ion uptake transporter activity
GO:0046873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal ion transmembrane transporter activity
GO:0046873	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heavy metal ion:hydrogen symporter activity
GO:0046873	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heavy metal ion transporter activity
GO:0046873	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heavy metal-exporting ATPase activity
REACT:R-XTR-373073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR1, 2 and 8 bind CCL16 ligand (Xenopus tropicalis)
RHEA:59556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiono-1,5-lactone = H(+) + N,N'-diacetylchitobionate
REACT:R-DRE-9024334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Danio rerio)
REACT:R-DME-193424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
GO:0004506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity
GO:0004506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene hydroxylase activity
GO:0004506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"squalene monooxygenase"
GO:0004506	skos:altLabel	"squalene epoxidase"
GO:0004506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene 2,3-oxidocyclase activity
GO:0004506	skos:prefLabel	"squalene monooxygenase"
GO:0004506	skos:altLabel	"squalene hydroxylase"
GO:0004506	skos:altLabel	"squalene-2,3-epoxidase"
GO:0004506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene monooxygenase activity
GO:0004506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene epoxidase activity
GO:0004506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene-2,3-epoxidase activity
GO:0004506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene oxydocyclase activity
GO:0004506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene-2,3-epoxide cyclase activity
GO:0004506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + squalene = (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-965067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THTPA:Mg2+ hydrolyzes ThTP to TDP (Danio rerio)
RHEA:63079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 2-acetylphloroglucinol + 3 CO2 + 4 CoA
REACT:R-HSA-177927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)
RHEA:18439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) => 4-CDP-2-C-methyl-D-erythritol + ATP
REACT:R-BTA-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Bos taurus)
REACT:R-DRE-2172666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds condensin II (Danio rerio)
RHEA:68276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + L-seryl-[protein] = CoA + O-butanoyl-L-seryl-[protein]
GO:0035276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol binding
REACT:R-GGA-5625421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The anterograde IFT train dissociates (Gallus gallus)
RHEA:21791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate
RHEA:23838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-alanine => D-methionine + pyruvate
GO:0004799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidylate synthase activity
GO:0004799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TMP synthetase activity
GO:0004799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTMP synthase activity
GO:0004799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylenetetrahydrofolate:dUMP C-methyltransferase activity
GO:0004799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity
GO:0004799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidylate synthetase activity
RHEA:24554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + H(+) + NADPH => 5alpha-cholestan-3-one + NADP(+)
REACT:R-XTR-426209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG activation of TRPC channels (Xenopus tropicalis)
REACT:R-CFA-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
REACT:R-DRE-8948018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Danio rerio)
REACT:R-DRE-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Danio rerio)
RHEA:70065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:42959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(38) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine
GO:0046703	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NKG2D receptor binding
GO:0046703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NK cell lectin-like receptor binding
GO:0046703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	natural killer cell lectin-like receptor binding
GO:0046703	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	KLRC4 receptor binding
REACT:R-BTA-388831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CD28 (Bos taurus)
REACT:R-BTA-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
REACT:R-HSA-9733964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Homo sapiens)
RHEA:23265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH
GO:0008915	skos:prefLabel	"lipid-A-disaccharide synthase"
GO:0008915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity
GO:0008915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipid-A-disaccharide synthase"
GO:0008915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid-A-disaccharide synthase activity
REACT:R-DRE-5693608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial resection of double-strand break ends (Danio rerio)
REACT:R-CFA-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
REACT:R-SSC-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Sus scrofa)
REACT:R-MMU-209087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)
RHEA:26429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + UTP <=> ADP + CTP + 2 H(+) + L-glutamate + phosphate
RHEA:13512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-CEL-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-DRE-2473596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP15 (Danio rerio)
REACT:R-RNO-5607736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 oligomerizes (Rattus norvegicus)
RHEA:27312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxychromene-2-carboxylate + H(+) => naphthalene-1,2-diol + O2
RHEA:50562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein]
REACT:R-SPO-4551649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO1 (Schizosaccharomyces pombe)
REACT:R-SSC-174122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Sus scrofa)
REACT:R-XTR-3364042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC promotes disassembly of beta-catenin transactivation complex (Xenopus tropicalis)
REACT:R-MMU-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Mus musculus)
REACT:R-PFA-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Plasmodium falciparum)
REACT:R-HSA-5607725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
REACT:R-GGA-8871194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
RHEA:46129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-4086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO2,3 (Drosophila melanogaster)
RHEA:31243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) = (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH
REACT:R-HSA-2514891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1 exchanges 4Na+ for Ca2+, K+ (Homo sapiens)
GO:0031784	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	melatonin receptor ligand
GO:0031784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melatonin receptor binding
REACT:R-GGA-177107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion and activation of the latent large complex of TGF-beta-1 (Gallus gallus)
REACT:R-XTR-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Xenopus tropicalis)
RHEA:33940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine + NADH + O2 => H2O + N(omega)-hydroxy-L-arginine + NAD(+)
REACT:R-HSA-5634103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 dissociates from atRA:RAR:RXR (Homo sapiens)
RHEA:14583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + NAD(+) => H(+) + 2 monodehydro-L-ascorbate radical + NADH
REACT:R-CFA-420131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PACAP receptor binds PACAP (Canis familiaris)
RHEA:36509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetracosanoyl-CoA + CO2 + CoA => docosanoyl-CoA + H(+) + malonyl-CoA
RHEA:40843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + FADH2
RHEA:49451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O <=> alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose
RHEA:44562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-heptaprenyl diphosphate
REACT:R-XTR-420582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin-1 trans heterodimer interaction (Xenopus tropicalis)
RHEA:57652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1alpha + H(+)
REACT:R-SSC-6784324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Sus scrofa)
RHEA:34131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neryl diphosphate + olivetolate = cannabinerolate + diphosphate
REACT:R-HSA-428522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of RAC1 (Homo sapiens)
REACT:R-BTA-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Bos taurus)
REACT:R-DRE-9020278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Danio rerio)
REACT:R-SSC-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Sus scrofa)
RHEA:59313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + O2 => D-galactono-1,5-lactone + H2O2
RHEA:35130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-D-glutamate(out) <=> L-alanyl-D-glutamate(in)
RHEA:69895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(out) + Na(+)(out) = cytidine(in) + Na(+)(in)
GO:0003997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA oxidase activity
GO:0003997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acyl-CoA oxidase activity
GO:0003997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:oxygen 2-oxidoreductase activity
GO:0003997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl coenzyme A oxidase activity
GO:0003997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acyl-coenzyme A oxidase activity
GO:0102470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity
REACT:R-SSC-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Sus scrofa)
REACT:R-DME-74736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)
REACT:R-RNO-9668597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase:primase binds G-strand of the telomere (Rattus norvegicus)
RHEA:18479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+) => 2,3-dihydroxybenzoate + O2
REACT:R-RNO-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Rattus norvegicus)
REACT:R-GGA-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Gallus gallus)
RHEA:40799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + H2O = 2-methylpropanoate + CoA + H(+)
RHEA:19882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-lysyl-[protein] => diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]
RHEA:70181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose => 2 D-maltotetraose
RHEA:22744	skos:prefLabel	"mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase"
RHEA:22744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase"
RHEA:22744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:44328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octanoylglycerol + H2O = glycerol + H(+) + octanoate
RHEA:43488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorophyll(ide) b reductase"
RHEA:43488	skos:altLabel	"Chl b reductase"
RHEA:43488	skos:altLabel	"chlorophyll b reductase"
RHEA:43488	skos:prefLabel	"chlorophyll(ide) b reductase"
RHEA:43488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyll a + NAD(+) = chlorophyll b + H(+) + NADH
REACT:R-MMU-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Mus musculus)
GO:1990725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose 6,6'-dimycolate receptor activity
GO:1990725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMD receptor activity
GO:1990725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cord factor receptor activity
RHEA:35535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-phenylalanyl-L-leucyl) + O2 = cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2
RHEA:34017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2
REACT:R-MMU-158860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates NHABP (Mus musculus)
REACT:R-HSA-549428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FACTOR VII (F7) (Homo sapiens)
REACT:R-MMU-5625745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 stimulates association of AR with NCOA2 (Mus musculus)
REACT:R-GGA-1370500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR binds SCF beta-TrCP complex (Gallus gallus)
RHEA:15387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-cyano-L-alanine + H2O => L-asparagine
REACT:R-RNO-8869606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NAR to yield NAMN (Rattus norvegicus)
REACT:R-MMU-1297444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of cAMP to HCN channels (Mus musculus)
REACT:R-BTA-804969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B1 hydrogenates E1 to EST17b (Bos taurus)
REACT:R-DME-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)
RHEA:51115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Mus musculus)
RHEA:24355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (R)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH
RHEA:25356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => 2,6,10,14-tetramethylpentadecanal + formyl-CoA
REACT:R-RNO-8987014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Rattus norvegicus)
REACT:R-RNO-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Rattus norvegicus)
REACT:R-HSA-6783556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIFR:JAKs bind gp130:JAKs:CNTFR (Homo sapiens)
RHEA:13183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + nitrate(in) + phosphate => ATP + H2O + nitrate(out)
REACT:R-MMU-936985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1 recruits TRAF6 (Mus musculus)
REACT:R-HSA-173647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of trimeric gp41:gp120 to plasma membrane (Homo sapiens)
REACT:R-MMU-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Mus musculus)
REACT:R-DME-1299338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRESK (Drosophila melanogaster)
REACT:R-MMU-1362465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GHR (Mus musculus)
REACT:R-GGA-5627072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds GOPC:CFTR (Gallus gallus)
REACT:R-HSA-9623192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6 (Homo sapiens)
RHEA:35021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine(out) => L-threonine(in)
REACT:R-CEL-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Caenorhabditis elegans)
REACT:R-BTA-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Bos taurus)
REACT:R-DDI-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:10660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] = D-seryl-[protein]
RHEA:10660	skos:prefLabel	"protein-serine epimerase"
RHEA:10660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-serine epimerase"
RHEA:10660	skos:altLabel	"protein-serine racemase"
REACT:R-SSC-5687183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKDC phosphorylates DCLRE1C at DNA DSBs (Sus scrofa)
RHEA:29344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate(in) + succinate(out) => L-aspartate(out) + succinate(in)
REACT:R-HSA-5205682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)
RHEA:35002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(in) + ATP(out) <=> ADP(out) + ATP(in)
RHEA:45314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin H2 => NADP(+) + prostaglandin F2alpha
GO:0019869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride channel inhibitor activity
RHEA:48397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine => 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine
RHEA:12954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]
REACT:R-RNO-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Rattus norvegicus)
REACT:R-DRE-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Danio rerio)
REACT:R-SPO-8878914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Schizosaccharomyces pombe)
RHEA:54661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic (S)-hydroxynitrile => an aromatic aldehyde + hydrogen cyanide
RHEA:44233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-DRE-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Danio rerio)
REACT:R-HSA-2395314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysino-5-ketonorleucine cross-links (Homo sapiens)
REACT:R-MMU-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Mus musculus)
EC:1.10.5.-	skos:prefLabel	"With a quinone or related compound as acceptor"
EC:1.10.5.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or related compound as acceptor"
REACT:R-CFA-9008587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37, IL37(?-218) binds IL18BP (Canis familiaris)
RHEA:35549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin] => cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-XTR-174121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Securin with Cdc20:APC/C complex (Xenopus tropicalis)
REACT:R-GGA-8851988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A2 binds T cell surface (Gallus gallus)
RHEA:13404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol <=> (2Z,6E)-farnesol
REACT:R-MMU-1236964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of peptide bound MHC class I complex to cell surface (Mus musculus)
REACT:R-BTA-936941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Bos taurus)
RHEA:13818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + H2O + phylloquinone => 2,3-epoxyphylloquinone + [protein]-dithiol
REACT:R-MMU-5684868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPC translocates from ER membrane to multivesicle body (Mus musculus)
REACT:R-HSA-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Homo sapiens)
RHEA:67793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleotidyl-uridine-RNA => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA
RHEA:28552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + N-acetylanthranilate => acetyl-CoA + anthranilate
RHEA:31862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> glutinol
REACT:R-SSC-9025995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Sus scrofa)
RHEA:18174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-octopamine => (4-hydroxyphenyl)acetaldehyde + NH4(+)
RHEA:66641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => diphosphate + koraiol
REACT:R-GGA-5688289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Gallus gallus)
REACT:R-GGA-1168644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Gallus gallus)
RHEA:32392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,4R)-dihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH
REACT:R-XTR-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Xenopus tropicalis)
REACT:R-DDI-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Dictyostelium discoideum)
RHEA:45903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3Z)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA
RHEA:23580	skos:altLabel	"prostacyclin synthase"
RHEA:23580	skos:altLabel	"PGI2 synthetase"
RHEA:23580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 = prostaglandin I2
RHEA:23580	skos:prefLabel	"prostaglandin-I synthase"
RHEA:23580	skos:altLabel	"PGI2 synthase"
RHEA:23580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prostaglandin-I synthase"
REACT:R-PFA-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Plasmodium falciparum)
RHEA:68141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-hexanedione + 2 H(+) + 2 NADPH => (2R,5R)-hexanediol + 2 NADP(+)
REACT:R-CFA-9692738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds HRH2 antagonists (Canis familiaris)
REACT:R-HSA-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)
REACT:R-SSC-201790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 is dephosphorylated on Thr75 by PP2A (Sus scrofa)
RHEA:49860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-2022851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfer GlcNAc to the heparan chain (Homo sapiens)
REACT:R-HSA-2424485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-PLCG1 (Homo sapiens)
REACT:R-RNO-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Rattus norvegicus)
RHEA:67535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine
REACT:R-HSA-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Homo sapiens)
REACT:R-DDI-6791227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Dictyostelium discoideum)
REACT:R-CFA-2464809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates the transport of atROL from ROS to RPE (Canis familiaris)
REACT:R-XTR-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Xenopus tropicalis)
REACT:R-GGA-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Gallus gallus)
REACT:R-SSC-375342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 36 mediated neuronal gap junction communication (Sus scrofa)
GO:1990663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroorotate dehydrogenase (fumarate) activity
REACT:R-HSA-141431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
GO:0005546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol 4,5-bisphosphate binding
GO:0005546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding
GO:0005546	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PIP2 binding
GO:0005546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtdIns(4,5)P2 binding
GO:0005546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-4,5-bisphosphate binding
REACT:R-DME-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)
REACT:R-DRE-975142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Danio rerio)
REACT:R-SCE-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Saccharomyces cerevisiae)
REACT:R-HSA-5690702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN phosphorylates CD22 (Homo sapiens)
RHEA:47660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-methionine sulfoximine = CoA + H(+) + N-acetyl-L-methionine sulfoximine
RHEA:53662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:66978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose
RHEA:60050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2
REACT:R-RNO-421833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Rattus norvegicus)
REACT:R-SPO-71286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)
REACT:R-HSA-912629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL is tyrosine phosphorylated (Homo sapiens)
GO:0018614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylbenzene dioxygenase activity
REACT:R-HSA-3900194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates DDX5 with SUMO2 (Homo sapiens)
REACT:R-BTA-2197697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Bos taurus)
RHEA:18524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	licodione + S-adenosyl-L-methionine <=> 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine
RHEA:60725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + H2O + NADP(+) => dodecanoate + 2 H(+) + NADPH
RHEA:62749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lovastatin => (S)-2-methylbutanoate + H(+) + monacolin J
RHEA:44295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
REACT:R-DME-209097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARM binds to APC and AXN in the 'destruction complex' (Drosophila melanogaster)
REACT:R-MMU-9018895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Mus musculus)
REACT:R-CEL-177107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion and activation of the latent large complex of TGF-beta-1 (Caenorhabditis elegans)
REACT:R-DME-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Drosophila melanogaster)
REACT:R-HSA-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Homo sapiens)
RHEA:29652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine(in) + L-arginine(out) => agmatine(out) + L-arginine(in)
RHEA:53569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:12935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + dihydroxyacetone phosphate => L-fuculose 1-phosphate
REACT:R-HSA-165055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)
RHEA:13007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine => (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine
RHEA:12022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O
REACT:R-RNO-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Rattus norvegicus)
REACT:R-HSA-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Homo sapiens)
RHEA:65864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxo-Delta(1)-steroid hydratase/dehydrogenase"
RHEA:65864	skos:prefLabel	"3-oxo-Delta(1)-steroid hydratase/dehydrogenase"
RHEA:65864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androst-1-ene-3,17-dione + A + H2O = 5alpha-androstan-1,3,17-trione + AH2
GO:0004620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase activity
GO:0004620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPH, I hydrolyse PA to 2-acyl LPA (Homo sapiens)
GO:0004620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDHD1,2 hydrolyse PA (Homo sapiens)
GO:0033857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPIP5K
GO:0033857	skos:altLabel	"diphosphoinositol pentakisphosphate kinase"
GO:0033857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PP-IP5 kinase activity
GO:0033857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diphosphoinositol-pentakisphosphate kinase"
GO:0033857	skos:altLabel	"PP-IP5 kinase"
GO:0033857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
GO:0033857	skos:prefLabel	"diphosphoinositol-pentakisphosphate kinase"
GO:0033857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
GO:0033857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphoinositol-pentakisphosphate kinase activity
GO:0033857	skos:altLabel	"PP-InsP5 kinase"
GO:0033857	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PP-InsP5 kinase activity
GO:0033857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphosphoinositol pentakisphosphate 3-kinase activity
RHEA:22687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 <=> (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O
RHEA:55291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetradecan-1-ol + tetradecanoyl-CoA <=> CoA + tetradecanyl tetradecanoate
REACT:R-HSA-421836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)
RHEA:24764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
RHEA:24764	skos:altLabel	"UDP-GlcNAc3NAcA 2-epimerase"
RHEA:24764	skos:altLabel	"UDP-alpha-D-GlcNAc3NAcA 2-epimerase"
RHEA:24764	skos:prefLabel	"UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase"
RHEA:24764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase"
RHEA:24764	skos:altLabel	"2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase"
REACT:R-GGA-6795667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the cytosol (Gallus gallus)
REACT:R-SCE-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Saccharomyces cerevisiae)
RHEA:42096	skos:altLabel	"tobramycin carbamoyltransferase"
RHEA:42096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamoyl phosphate + H2O + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate
RHEA:42096	skos:prefLabel	"nebramycin 5' synthase"
RHEA:42096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamoyl phosphate + H2O + tobramycin = AMP + diphosphate + H(+) + nebramycin 5' + phosphate
RHEA:42096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nebramycin 5' synthase"
REACT:R-BTA-264976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Bos taurus)
RHEA:59907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + octanal <=> 2 H(+) + NADPH + octanoate
GO:0015369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium:proton antiporter activity
GO:0015369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium:hydrogen antiporter activity
RHEA:48808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
RHEA:31844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA => 2-oxepin-2(3H)-ylideneacetyl-CoA
RHEA:55748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:55748	skos:prefLabel	"H2:CoB-CoM heterodisulfide,ferredoxin reductase"
RHEA:55748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"H2:CoB-CoM heterodisulfide,ferredoxin reductase"
GO:0070736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein glycylase activity, initiating
GO:0070736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glycine ligase activity, initiating
RHEA:69611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kojibiose = beta-D-glucose + D-glucose
REACT:R-RNO-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Rattus norvegicus)
RHEA:72177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out) => 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in)
REACT:R-GGA-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)
RHEA:59436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] = 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate
RHEA:27645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + phosphate <=> adenine + alpha-D-ribose 1-phosphate
RHEA:13841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diferric-transferrin reductase"
RHEA:13841	skos:altLabel	"transferrin reductase"
RHEA:13841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(II)2-[transferrin] + H(+) + NAD(+) = Fe(III)2-[transferrin] + NADH
RHEA:13841	skos:prefLabel	"diferric-transferrin reductase"
REACT:R-BTA-9033949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Bos taurus)
REACT:R-HSA-9686790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER-alpha glucosidases bind ER-alpha glucosidase inhibitors (Homo sapiens)
EC:3.4.17.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxypeptidase M"
EC:3.4.17.12	skos:prefLabel	"carboxypeptidase M"
REACT:R-RNO-9020275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DHA to 17(S)-Hp-DHA (Rattus norvegicus)
RHEA:42627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-ureidoacrylate + H(+) + H2O <=> (Z)-3-aminoacrylate + CO2 + NH4(+)
GO:0046899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside triphosphate adenylate kinase activity
GO:0046899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside triphosphate-adenosine monophosphate transphosphorylase activity
GO:0046899	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GTP:AMP phosphotransferase
GO:0046899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside-triphosphate:AMP phosphotransferase activity
GO:0046899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isozyme 3 of adenylate kinase activity
GO:0046899	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	guanosine triphosphate-adenylate kinase
GO:0046899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-triphosphate-adenylate kinase activity
RHEA:32738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
RHEA:16575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate => 2-oxoglutarate + 4-(phosphooxy)-L-threonine
REACT:R-HSA-1497863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The BH3 radical can decay to dihydrobiopterin (BH2) (Homo sapiens)
REACT:R-DRE-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Danio rerio)
REACT:R-SSC-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Sus scrofa)
REACT:R-MMU-6804485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates L3MBTL2 with SUMO2 (Mus musculus)
RHEA:24145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
REACT:R-GGA-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Gallus gallus)
RHEA:27845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-carbazole + H(+) + NADPH + O2 <=> 2'-aminobiphenyl-2,3-diol + NADP(+)
RHEA:25921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-7-ol => 7-hydroxyquinolin-2(1H)-one + AH2
REACT:R-HSA-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Homo sapiens)
REACT:R-GGA-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Gallus gallus)
RHEA:15419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-tyrosine + NADPH => L-arogenate + NADP(+)
REACT:R-RNO-192097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Rattus norvegicus)
RHEA:19059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O => a hydroperoxy polyunsaturated fatty acid + 2 glutathione
RHEA:69211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate
REACT:R-HSA-2534388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone Activation Of CatSper (Homo sapiens)
RHEA:45434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate => H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:59692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotriono-1,5-lactone + H2O = D-cellotrionate + H(+)
EC:2.8.2.24	skos:prefLabel	"aromatic desulfoglucosinolate sulfotransferase"
EC:2.8.2.24	skos:altLabel	"PAPS-desulfoglucosinolate sulfotransferase"
EC:2.8.2.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aromatic desulfoglucosinolate sulfotransferase"
EC:2.8.2.24	skos:altLabel	"desulfoglucosinolate sulfotransferase"
RHEA:35375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O = (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate
REACT:R-RNO-8848314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36:IL1RL2 binds IL1RAP-1 (Rattus norvegicus)
REACT:R-MMU-8984021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Mus musculus)
REACT:R-GGA-909718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of p-STAT1 homodimer (Gallus gallus)
REACT:R-SSC-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Sus scrofa)
RHEA:59579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anserine + H2O <=> beta-alanine + N(pros)-methyl-L-histidine
RHEA:44618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O
RHEA:14283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate => 2 Fe(III)-[cytochrome c] + H2O + sulfite
GO:0018583	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)
GO:0018583	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2,3-dihydroxybiphenyl dioxygenase activity
GO:0018583	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biphenyl-2,3-diol dioxygenase activity
GO:0018583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,3-diol 1,2-dioxygenase activity
GO:0018583	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2,3-dihydroxybiphenyl 1,2-dioxygenase activity
RHEA:62374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA
RHEA:32639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-1604741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP14 (MT1-MMP) (Caenorhabditis elegans)
REACT:R-RNO-174157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cyclin B (Rattus norvegicus)
GO:1990080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine receptor activity
GO:1990080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-phenylethylamine receptor activity
RHEA:18607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+) => 1-amino-1-deoxy-scyllo-inositol + ATP
REACT:R-MMU-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Mus musculus)
GO:0045517	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-20 receptor ligand
GO:0045517	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-20
GO:0045517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-20 receptor binding
RHEA:59726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaonate + H(+) => D-maltoheptaono-1,5-lactone + H2O
REACT:R-XTR-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Xenopus tropicalis)
REACT:R-RNO-8866405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)
RHEA:23799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-O-acetylnorajmaline + H2O <=> acetate + H(+) + norajmaline
REACT:R-MMU-2129362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin microfibril assembly (Mus musculus)
REACT:R-DME-9626928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP binds FOXO1 (Drosophila melanogaster)
RHEA:24333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-3,5-dihydromonacolin L carboxylate => H2O + monacolin L carboxylate
REACT:R-SSC-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Sus scrofa)
RHEA:34996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnose(in) => L-rhamnose(out)
REACT:R-PFA-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Plasmodium falciparum)
REACT:R-XTR-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Xenopus tropicalis)
RHEA:29543	skos:altLabel	"Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha1,2-glucosyltransferase"
RHEA:29543	skos:prefLabel	"dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase"
RHEA:29543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase"
RHEA:29543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:18622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2S)-flavan-4-one + O2 => a (2R,3R)-dihydroflavonol + CO2 + succinate
REACT:R-CFA-8948228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Canis familiaris)
REACT:R-DME-2750187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Drosophila melanogaster)
RHEA:21518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	piperitenone => isopiperitenone
RHEA:40971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-DRE-982810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation (Danio rerio)
RHEA:44281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA
GO:0047379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent-short-chain-acyl-CoA hydrolase activity
GO:0047379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-dependent short-chain-acyl-CoA hydrolase activity
GO:0047379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent short-chain acyl coenzyme A hydrolase activity
GO:0047379	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ADP-dependent propionyl-CoA thioesterase activity
GO:0047379	skos:prefLabel	"ADP-dependent short-chain-acyl-CoA hydrolase"
GO:0047379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent short-chain acyl-CoA thioesterase activity
GO:0047379	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ADP-dependent propionyl coenzyme A hydrolase activity
GO:0047379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent short-chain acyl-CoA hydrolase activity
GO:0047379	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ADP-dependent propionyl-CoA hydrolase activity
GO:0047379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty acyl-CoA + H2O = a short-chain fatty acid + CoA + H(+)
GO:0047379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-dependent short-chain-acyl-CoA hydrolase"
RHEA:33638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + docosanoate <=> AMP + diphosphate + docosanoyl-CoA
GO:0051400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH domain binding
GO:0051400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bcl-2 homology domain binding
REACT:R-HSA-390251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Homo sapiens)
REACT:R-SSC-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Sus scrofa)
RHEA:67427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid + H2O <=> a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)
REACT:R-SSC-2029268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of PLCG (Sus scrofa)
REACT:R-XTR-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Xenopus tropicalis)
GO:0030777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity
GO:0030777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity
GO:0030777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine 9-O-methyltransferase activity
REACT:R-XTR-388817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICOS binds ICOSL/B7-H2 (Xenopus tropicalis)
REACT:R-SSC-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Sus scrofa)
REACT:R-HSA-1482776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Homo sapiens)
REACT:R-DRE-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Danio rerio)
RHEA:57763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
RHEA:71014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(in) + L-phenylalanine(out) <=> L-isoleucine(out) + L-phenylalanine(in)
REACT:R-HSA-170704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
REACT:R-SCE-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Saccharomyces cerevisiae)
REACT:R-RNO-5621355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Rattus norvegicus)
REACT:R-CEL-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
REACT:R-CEL-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Caenorhabditis elegans)
RHEA:53277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9014294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the plasma membrane (Homo sapiens)
REACT:R-CEL-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)
REACT:R-RNO-5358599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Rattus norvegicus)
REACT:R-BTA-69144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 (Bos taurus)
REACT:R-SPO-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Schizosaccharomyces pombe)
REACT:R-MMU-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Mus musculus)
REACT:R-SSC-351877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 2 (Sus scrofa)
GO:0004413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HSK
GO:0004413	skos:prefLabel	"homoserine kinase"
GO:0004413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homoserine kinase activity
GO:0004413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine
GO:0004413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homoserine kinase"
GO:0004413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:L-homoserine O-phosphotransferase activity
GO:0004413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoserine kinase (phosphorylating)
RHEA:53516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:68955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoscopoletin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + scoparone
REACT:R-SSC-5423653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGST trimers transfer GS from GSH to AFXBO and AFNBO (Sus scrofa)
REACT:R-GGA-177937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of EGFR by SRC kinase (Gallus gallus)
REACT:R-SSC-1306953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)
REACT:R-DRE-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Danio rerio)
RHEA:54900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-[ACP] + H(+) + NADH = hexadecanoyl-[ACP] + NAD(+)
GO:0097005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adipokinetic hormone receptor binding
GO:0097005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKH receptor binding
REACT:R-RNO-193393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Rattus norvegicus)
REACT:R-SCE-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Saccharomyces cerevisiae)
RHEA:14685	skos:altLabel	"polyethylene glycol dehydrogenase"
RHEA:14685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkan-1-ol dehydrogenase (acceptor)"
RHEA:14685	skos:prefLabel	"alkan-1-ol dehydrogenase (acceptor)"
RHEA:14685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a primary alcohol = AH2 + an aldehyde
REACT:R-BTA-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Bos taurus)
REACT:R-DRE-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Danio rerio)
RHEA:39337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH
RHEA:31968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-SCE-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Saccharomyces cerevisiae)
REACT:R-MMU-375160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 binds to ATP (Mus musculus)
REACT:R-HSA-9694567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pp1a forms a dimer (Homo sapiens)
REACT:R-HSA-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
REACT:R-SCE-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Saccharomyces cerevisiae)
RHEA:55016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menthone + NADPH + O2 = 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)
REACT:R-HSA-8948832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)
REACT:R-DRE-173740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to C3(H2O) (Danio rerio)
REACT:R-CFA-508308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Canis familiaris)
REACT:R-BTA-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Bos taurus)
REACT:R-DRE-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Danio rerio)
RHEA:53642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-alpha-amorphene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:27960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine + D-ribose => cytidine + H2O
RHEA:69597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + inosine => adenosine + IMP
REACT:R-RNO-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Rattus norvegicus)
REACT:R-BTA-997314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of JAK1 by SHP1 (Bos taurus)
RHEA:58715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + O2 + rifampicin <=> H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide
RHEA:68006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chloride + ethene + H(+) => AH2 + chloroethene
REACT:R-GGA-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Gallus gallus)
RHEA:45334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+) => 7,8-dihydroneopterin + O2
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-20-hydroxysteroid dehydrogenase activity
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dehydrogenase, 20beta-hydroxy steroid
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	delta4-3-ketosteroid hydrogenase activity
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha(or 20beta)-hydroxysteroid dehydrogenase activity
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cortisone reductase activity
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	20beta-HSD
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	20beta-hydroxysteroid dehydrogenase activity
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADH-20beta-hydroxysteroid dehydrogenase activity
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androstan-3-alpha,17-beta-diol dehydrogenase activity
GO:0047044	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity
RHEA:24997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-379415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Drosophila melanogaster)
REACT:R-RNO-202137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
REACT:R-DRE-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Danio rerio)
REACT:R-HSA-8866553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded CFTR is degraded by the 26S proteasome (Homo sapiens)
REACT:R-SSC-2730841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV (Sus scrofa)
REACT:R-RNO-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Rattus norvegicus)
REACT:R-RNO-3341343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Rattus norvegicus)
REACT:R-MMU-5626981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Mus musculus)
GO:0140765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone H3-K56 deacetylase activity
GO:0140765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone H3K56 deacetylase activity
GO:0140765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone deacetylase activity (H3-K56 specific)
REACT:R-CFA-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Canis familiaris)
REACT:R-CEL-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Caenorhabditis elegans)
RHEA:19688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + tyramine <=> CoA + H(+) + N-[(E)-feruloyl]tyramine
RHEA:32598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-isopropyl-4-methyloxepan-2-one + H2O <=> 6-hydroxy-3,7-dimethyloctanoate + H(+)
REACT:R-SSC-706479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated (Sus scrofa)
GO:0043169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation binding
RHEA:37353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + phosphate => cytidine 2'-phosphate + H2O
GO:0045506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-24R
GO:0045506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-24 receptor activity
GO:0045506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-24 receptor activity
RHEA:62793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + NADPH + O2 + 2 rubrofusarin B => 2 H2O + NADP(+) + nigerone
REACT:R-RNO-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Rattus norvegicus)
REACT:R-SSC-382054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binds to extracellular matrix proteins (Sus scrofa)
RHEA:30583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide = 2-demethylmenaquinone-8 + H2O + trimethylamine
REACT:R-CEL-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Caenorhabditis elegans)
REACT:R-HSA-8952226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the BCL2L11 (BIM) gene (Homo sapiens)
RHEA:17734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylenedicarboxylate + H(+) + H2O => CO2 + pyruvate
REACT:R-SSC-2176445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD2 (Sus scrofa)
RHEA:23906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide] => an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide]
REACT:R-HSA-8856630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIDEA:CIDEC binds lipid droplets (Homo sapiens)
RHEA:67374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + L-threonine => H2O + L-seryl-L-threonine
RHEA:46457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)
GO:0140618	skos:altLabel	"NADH:Fe(3+)-EDTA reductase"
GO:0140618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric-chelate reductase (NADH) activity
GO:0140618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH:Fe(3+) oxidoreductase activity
GO:0140618	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ferric chelate reductase activity
GO:0140618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferric-chelate reductase (NADH)"
GO:0140618	skos:altLabel	"iron chelate reductase"
GO:0140618	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	iron chelate reductase activity
GO:0140618	skos:altLabel	"NADH:Fe(3+) oxidoreductase"
GO:0140618	skos:altLabel	"ferric chelate reductase"
GO:0140618	skos:prefLabel	"ferric-chelate reductase (NADH)"
GO:0140618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH:Fe3+ oxidoreductase activity
REACT:R-SSC-936963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization (Sus scrofa)
RHEA:55897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + L-tryptophan + O2 => 5-chloro-L-tryptophan + FAD + 2 H2O
REACT:R-BTA-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Bos taurus)
RHEA:47518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
REACT:R-CFA-5654655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PPTN11 (Canis familiaris)
REACT:R-HSA-5659879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SI does not hydrolyze iMal (Homo sapiens)
REACT:R-MMU-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Mus musculus)
RHEA:14849	skos:prefLabel	"amidinoaspartase"
RHEA:14849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-amidino-L-aspartate = L-aspartate + urea
RHEA:14849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amidinoaspartase"
RHEA:70283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylputrescine + O2 = 4-acetamidobutanal + H2O2 + NH4(+)
RHEA:58248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]
REACT:R-HSA-933539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IKK complex (Homo sapiens)
REACT:R-HSA-373339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)
EC:3.4.24.58	skos:altLabel	"RVV-X"
EC:3.4.24.58	skos:prefLabel	"russellysin"
EC:3.4.24.58	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"russellysin"
EC:3.4.24.58	skos:altLabel	"blood-coagulation factor X-activating enzyme"
EC:3.4.24.58	skos:altLabel	"Russell's viper venom factor X activator"
RHEA:71504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)
RHEA:20063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + dCMP + H(+) => 2'-deoxycytidine + a ribonucleoside 5'-triphosphate
REACT:R-RNO-5665982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Rattus norvegicus)
RHEA:56074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP => a 2-acylphloroglucinol + UDP-alpha-D-glucose
REACT:R-MMU-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Mus musculus)
RHEA:21975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-1 + S-adenosyl-L-methionine <=> precorrin-2 + S-adenosyl-L-homocysteine
GO:0032567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP binding
REACT:R-MMU-5676599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF trimer binds BAFFR (Mus musculus)
RHEA:60044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP
GO:0140908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H3-K122 specific)
GO:0140908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K122 acetyltransferase activity
GO:0140908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H3-K122 specific)
GO:0140908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H3-K122 specific)
GO:0140908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K122 acetyltransferase activity
REACT:R-DDI-8875902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC45A3 transports Glc from extracellular region to cytosol (Dictyostelium discoideum)
REACT:R-RNO-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:50265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-183094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)
RHEA:22760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cypridina luciferin + O2 = CO2 + hnu + oxidized Cypridina luciferin
RHEA:22760	skos:prefLabel	"Cypridina-luciferin 2-monooxygenase"
RHEA:22760	skos:altLabel	"luciferase"
RHEA:22760	skos:altLabel	"Cypridina-type luciferase"
RHEA:22760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Cypridina-luciferin 2-monooxygenase"
REACT:R-BTA-8877192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds FOXP3 (Bos taurus)
REACT:R-RNO-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Rattus norvegicus)
REACT:R-GGA-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Gallus gallus)
RHEA:43880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA = (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate
REACT:R-CEL-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Caenorhabditis elegans)
REACT:R-RNO-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Rattus norvegicus)
GO:0106421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate:proton antiporter activity
REACT:R-CFA-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Canis familiaris)
RHEA:47617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethionamide + H(+) + NADPH + O2 => ethionamide S-oxide + H2O + NADP(+)
GO:1904315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential
GO:1904315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GO:1904315	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
GO:0061134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidase regulator activity
RHEA:34501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate => 1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-RNO-8851888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds SHC1-2 (Rattus norvegicus)
RHEA:68064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-8851866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds RANBP10 (Gallus gallus)
REACT:R-DME-1475414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Drosophila melanogaster)
REACT:R-BTA-1169398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host protein filamin B (Bos taurus)
GO:0018599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutyrate 3-monooxygenase activity
REACT:R-MMU-193700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR ICD signals to NF-kB (Mus musculus)
RHEA:13960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H2O + O2 + 4 sulfur <=> 6 H(+) + 2 hydrogen sulfide + 2 sulfite
REACT:R-HSA-201425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Homo sapiens)
REACT:R-GGA-9734070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET recombinant therapeutic antibodies bind MET (Gallus gallus)
REACT:R-DRE-400183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA:RXRA binds Corepressors of PPARA (Danio rerio)
RHEA:67875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose <=> 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP
RHEA:44179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-diacyl-sn-glycerol + H2O <=> 3-acyl-sn-glycerol + a fatty acid + H(+)
REACT:R-HSA-5672329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CLIP1 and microtubules (Homo sapiens)
GO:0031770	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	growth hormone-releasing hormone receptor ligand
GO:0031770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth hormone-releasing hormone receptor binding
REACT:R-RNO-2424482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)
RHEA:36714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + H2O + O-ureido-D-serine <=> ADP + CO2 + D-cycloserine + NH4(+) + phosphate
RHEA:63102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascochlorin + 2 H2O + NADP(+) => H(+) + ilicicolin C + NADPH + O2
REACT:R-SSC-9748983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6MP, forming 6MeMP (Sus scrofa)
RHEA:15836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelate + H(+) + O2 <=> 4-hydroxybenzaldehyde + CO2 + H2O2
REACT:R-MMU-9668902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18-RFC(7s) complex (Mus musculus)
REACT:R-HSA-446694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 phosphorylates IRAK1 (Homo sapiens)
RHEA:18391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + UDP-alpha-D-xylose => alpha-D-xylose 1-phosphate + H(+) + UTP
REACT:R-MMU-3323013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
REACT:R-GGA-8948832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 polyubiquitinates PARylated PTEN (Gallus gallus)
RHEA:33527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol = CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate
REACT:R-MMU-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Mus musculus)
RHEA:12550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisic aldehyde + H(+) + NADH => 2-cis,4-trans-xanthoxin + NAD(+)
GO:0160013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
GO:0160013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent protein de-2-hydroxyisobutyrylase activity
GO:0030881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-2-microglobulin binding
GO:0051431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR2 binding
GO:0051431	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 corticotropin releasing factor receptor ligand
GO:0051431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 corticotropin-releasing factor receptor binding
GO:0051431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 corticotropin releasing factor receptor binding
GO:0051431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin-releasing hormone receptor 2 binding
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate dehydratase activity
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-dehydroquinate hydro-lyase activity
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHQase
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydroquinate dehydratase activity
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydroquinate hydro-lyase activity
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-dehydroquinate dehydratase activity
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydroquinase activity
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydroquinate hydrolase activity
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-dehydroquinase activity
GO:0003855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydroquinase activity
GO:0102344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-behenoyl-CoA dehydratase activity
RHEA:46189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic nitrile + 2 H2O => a carboxylate + NH4(+)
RHEA:72869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A[3'-5']pG[3'-5']pAp[3'] + H(+) => 3',3',3'-cAAG + H2O
RHEA:17657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + dihydroxyacetone phosphate = a 1-acylglycerone 3-phosphate + CoA
RHEA:17657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerone-phosphate O-acyltransferase"
RHEA:17657	skos:altLabel	"dihydroxyacetone phosphate acyltransferase"
RHEA:17657	skos:prefLabel	"glycerone-phosphate O-acyltransferase"
REACT:R-HSA-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Homo sapiens)
REACT:R-SCE-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Saccharomyces cerevisiae)
REACT:R-DME-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Drosophila melanogaster)
RHEA:37357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + uridine => H2O + uridine 2'-phosphate
REACT:R-CEL-5138432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 is phosphorylated by PKC (Caenorhabditis elegans)
RHEA:52708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H2O = D-ribose 5-phosphate + guanine
REACT:R-MMU-8877620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE2 cleaves EDN1(53-90) (Mus musculus)
RHEA:13354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)
REACT:R-GGA-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Gallus gallus)
RHEA:17114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine-phosphoethanolamine => H(+) + L-serine + phosphoethanolamine
RHEA:33959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neomycin C transaminase"
RHEA:33959	skos:prefLabel	"neomycin C transaminase"
RHEA:33959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + neomycin C = 6'''-deamino-6'''-oxoneomycin C + L-glutamate
REACT:R-GGA-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Gallus gallus)
REACT:R-XTR-8938300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vanin hydrolyses pantetheine to PanK, 2AET (Xenopus tropicalis)
REACT:R-HSA-109530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Homo sapiens)
RHEA:68332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + H2O = (R)-pantothenate + phosphate
RHEA:12631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-6-hydroxyhyoscyamine + CO2 + succinate => 2-oxoglutarate + L-hyoscyamine + O2
EC:3.2.1.134	skos:prefLabel	"difructose-anhydride-I synthase"
EC:3.2.1.134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"difructose-anhydride-I synthase"
EC:3.2.1.134	skos:altLabel	"DFAIase"
EC:3.2.1.134	skos:altLabel	"inulobiose hydrolase"
EC:3.2.1.134	skos:altLabel	"bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase"
REACT:R-DRE-2022911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSPG is secreted (Danio rerio)
RHEA:22257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA + NADP(+) => a 3-oxoacyl-CoA + H(+) + NADPH
REACT:R-MMU-1006169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds host cell surface markers (Mus musculus)
REACT:R-XTR-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:32636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Rattus norvegicus)
RHEA:42376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate
REACT:R-DME-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Drosophila melanogaster)
REACT:R-HSA-8939129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-215 binds RUNX1 mRNA (Homo sapiens)
RHEA:44139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl dodecanoate
RHEA:66714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene
GO:0102596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity
REACT:R-DRE-5609665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHUK, IKBKB and IKBKG form IKK complex (Danio rerio)
RHEA:38971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O2
REACT:R-DME-9632033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GalNAc to chondroitin (Drosophila melanogaster)
GO:0018485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylaldehyde dehydrogenase activity
GO:0018485	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	salicylaldehyde:NAD+ oxidoreductase activity
GO:0034808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzo(a)pyrene 4,5-dioxygenase activity
GO:0102828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stachyose galactinol:verbascose galactosyltransferase activity
REACT:R-BTA-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Bos taurus)
RHEA:28970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline(in) + Na(+)(in) <=> L-proline(out) + Na(+)(out)
REACT:R-DRE-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Danio rerio)
GO:0047968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate dehydrogenase (acylating) activity
GO:0047968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)
REACT:R-CFA-2327695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Canis familiaris)
RHEA:36674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z)-hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine
REACT:R-DME-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Drosophila melanogaster)
RHEA:50603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[histone H2A] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]
RHEA:56940	skos:prefLabel	"5-deoxyribulose 1-phosphate aldolase"
RHEA:56940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-deoxyribulose 1-phosphate aldolase"
RHEA:56940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-ribulose 1-phosphate = acetaldehyde + dihydroxyacetone phosphate
RHEA:56940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate = 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate
RHEA:56940	skos:altLabel	"5-(methylthio)ribulose-1-phosphate aldolase"
REACT:R-GGA-5578742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO1,2:small RNA complexes interact with chromatin (Gallus gallus)
REACT:R-MMU-193068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates PREG (Mus musculus)
RHEA:48301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin F2alpha 1-glyceryl ester => glycerol + H(+) + prostaglandin F2alpha
RHEA:11263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 <=> H2O2 + NADP(+)
RHEA:48678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:72269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + formate(out) => chloride(out) + formate(in)
REACT:R-HSA-6789185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chloride ion and N-acyl group react to chloramide (Homo sapiens)
REACT:R-CEL-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)
REACT:R-BTA-5683735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 is recruited to DNA DSBs (Bos taurus)
RHEA:40958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-phosphomevalonate + ATP <=> ADP + CO2 + isopentenyl phosphate + phosphate
REACT:R-HSA-5651992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)
REACT:R-DDI-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Dictyostelium discoideum)
RHEA:40189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O
EC:3.1.26.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease III"
EC:3.1.26.3	skos:altLabel	"RNase III"
EC:3.1.26.3	skos:altLabel	"ribonuclease 3"
EC:3.1.26.3	skos:prefLabel	"ribonuclease III"
REACT:R-MMU-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Mus musculus)
REACT:R-XTR-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Xenopus tropicalis)
RHEA:69442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH => 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+)
RHEA:71233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(2+)-[Dph3] + H(+) + NAD(+) => 2 Fe(3+)-[Dph3] + NADH
REACT:R-SPO-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Schizosaccharomyces pombe)
RHEA:64935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + 2 H2O <=> dGMP + 2 H(+) + 2 phosphate
REACT:R-BTA-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Bos taurus)
RHEA:41820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:56928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Schizosaccharomyces pombe)
REACT:R-HSA-199839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate RSK (Homo sapiens)
RHEA:11423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + senecionine <=> H2O + NADP(+) + senecionine N-oxide
REACT:R-SPO-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Schizosaccharomyces pombe)
REACT:R-CFA-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Canis familiaris)
REACT:R-CFA-5682084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Canis familiaris)
REACT:R-XTR-110350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of TDG glycosylase by APEX1 at the AP site (Xenopus tropicalis)
REACT:R-CFA-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Canis familiaris)
RHEA:35641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + pyruvate => (4S)-4-hydroxy-2-oxoglutarate
REACT:R-GGA-5653756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM25 binds monoUb:164-PCNA (Gallus gallus)
REACT:R-CFA-110231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by MBD4 glycosylase (Canis familiaris)
REACT:R-BTA-211983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2J2 oxidises ARA (Bos taurus)
REACT:R-MMU-6788523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to Complex I subunits (Mus musculus)
REACT:R-HSA-2064406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Homo sapiens)
RHEA:46021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate, water dikinase] + ADP => [pyruvate, water dikinase]-phosphate + AMP + H(+)
REACT:R-BTA-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Bos taurus)
REACT:R-CFA-390329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of AKT by PP2A (Canis familiaris)
RHEA:43824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate
RHEA:14729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructose-bisphosphate aldolase"
RHEA:14729	skos:altLabel	"fructose-1,6-bisphosphate triosephosphate-lyase"
RHEA:14729	skos:altLabel	"D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase"
RHEA:14729	skos:altLabel	"aldolase"
RHEA:14729	skos:prefLabel	"fructose-bisphosphate aldolase"
RHEA:14729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
GO:0034810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-dihydroxybenzo(a)pyrene dioxygenase activity
RHEA:45751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA
REACT:R-GGA-2168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds DLL4 (Gallus gallus)
REACT:R-RNO-211874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2S1 4-hydroxylates atRA (Rattus norvegicus)
REACT:R-BTA-400509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Bos taurus)
RHEA:33172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose(in) => D-maltose(out)
RHEA:11862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(tele)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]
RHEA:65078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
REACT:R-XTR-8852010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL2 binds activated T cells surface (Xenopus tropicalis)
RHEA:67421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid + H2O => a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)
REACT:R-MMU-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Mus musculus)
RHEA:24557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) => 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH
REACT:R-MMU-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Mus musculus)
RHEA:26232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 NADP(+) + phytyl diphosphate <=> geranylgeranyl diphosphate + 3 H(+) + 3 NADPH
RHEA:27786	skos:prefLabel	"2-oxoglutarate dehydrogenase system"
RHEA:27786	skos:altLabel	"2-oxoglutarate dehydrogenase complex"
RHEA:27786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoglutarate dehydrogenase system"
RHEA:27786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CoA + NAD(+) = CO2 + NADH + succinyl-CoA
REACT:R-BTA-1358790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates ERBB3 (Bos taurus)
REACT:R-DME-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Drosophila melanogaster)
RHEA:61318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-2730959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN7:OSTM1 exchanges Cl- for H+ (Danio rerio)
REACT:R-CEL-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Caenorhabditis elegans)
RHEA:32360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + 2 ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)
REACT:R-GGA-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Gallus gallus)
REACT:R-HSA-3769401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKK and KRM bind LRP5/6 (Homo sapiens)
REACT:R-MMU-9731931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds selective ERAs (Mus musculus)
RHEA:56175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + O2 <=> 8-demethyl-8-formylriboflavin 5'-phosphate + H2O
REACT:R-DRE-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Danio rerio)
RHEA:39103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sitosterol(in) = ADP + H(+) + phosphate + sitosterol(out)
RHEA:55183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylnonanoyl-CoA + O2 <=> 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate
REACT:R-DME-936942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Drosophila melanogaster)
REACT:R-HSA-373342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3CR1 binds CX3CL1 (Homo sapiens)
REACT:R-MMU-8850560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha releases G-protein heterotrimer from PDCL  (Mus musculus)
REACT:R-HSA-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Homo sapiens)
REACT:R-MMU-2161779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LXA4 is oxidised to 15k-LXA4 by HPGD (Mus musculus)
RHEA:46163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H(+) + NADH <=> a quinol + NAD(+)
RHEA:13372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate <=> diphosphate + isoprene
RHEA:67579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O <=> [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine
REACT:R-MMU-168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNKs phosphorylate c-JUN (Mus musculus)
REACT:R-CFA-1169397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ISG15 by UBA7 E1 ligase (Canis familiaris)
REACT:R-PFA-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Plasmodium falciparum)
REACT:R-CEL-5693751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH2 hydrolyses AEA to AA and ETA (Caenorhabditis elegans)
REACT:R-HSA-380216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)
REACT:R-SSC-109813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1 binds SOS1 (Sus scrofa)
GO:0160012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone decrotonylase activity
GO:0032556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine deoxyribonucleotide binding
REACT:R-HSA-8863009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Influx of extracellular calcium (Homo sapiens)
REACT:R-MMU-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Mus musculus)
RHEA:21160	skos:altLabel	"ATP-citrate (pro-S-)-lyase"
RHEA:21160	skos:altLabel	"adenosine triphosphate citrate lyase"
RHEA:21160	skos:altLabel	"ATP citrate (pro-S)-lyase"
RHEA:21160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA
RHEA:21160	skos:prefLabel	"ATP citrate synthase"
RHEA:21160	skos:altLabel	"citrate-ATP lyase"
RHEA:21160	skos:altLabel	"ATP-citric lyase"
RHEA:21160	skos:altLabel	"citric cleavage enzyme"
RHEA:21160	skos:altLabel	"acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)"
RHEA:21160	skos:altLabel	"ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO(-)->acetyl-CoA] (ATP-dephosphorylating)"
RHEA:21160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ATP citrate synthase"
RHEA:21160	skos:altLabel	"citrate cleavage enzyme"
EC:3.1.1.106	skos:prefLabel	"O-acetyl-ADP-ribose deacetylase"
EC:3.1.1.106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-acetyl-ADP-ribose deacetylase"
REACT:R-HSA-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Homo sapiens)
RHEA:10739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + NAD(+) <=> an aldehyde + H(+) + NADH
REACT:R-HSA-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Homo sapiens)
REACT:R-BTA-5625745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 stimulates association of AR with NCOA2 (Bos taurus)
RHEA:34570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-paratose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH
RHEA:42815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + octadecanoyl-CoA <=> cholesteryl octadecanoate + CoA
REACT:R-BTA-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Bos taurus)
RHEA:12741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + H2O = IDP + NH4(+)
REACT:R-XTR-114307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SMAC (DIABLO) from mitochondria (Xenopus tropicalis)
REACT:R-MMU-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Mus musculus)
RHEA:41086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-HSA-8985914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Homo sapiens)
REACT:R-GGA-9656893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1MW binds 11cRAL (Gallus gallus)
RHEA:40337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP
RHEA:55427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:64593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base
RHEA:17754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine
RHEA:72318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(in) + leukotriene C4(out) <=> glutathione(out) + leukotriene C4(in)
REACT:R-MMU-8938231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds CREBBP (Mus musculus)
REACT:R-MMU-5684882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 is recruited to resected DNA DSBs (Mus musculus)
REACT:R-MMU-5685318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex formation (Mus musculus)
REACT:R-RNO-2172678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates histone H4K20me1 (Rattus norvegicus)
RHEA:71019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + L-valine(in) = L-phenylalanine(in) + L-valine(out)
REACT:R-GGA-8987012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Gallus gallus)
GO:0120108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA-3'-diphospho-5'-guanosine diphosphatase"
GO:0120108	skos:altLabel	"DNA-3'pp5'G guanylate hydrolase"
GO:0120108	skos:prefLabel	"DNA-3'-diphospho-5'-guanosine diphosphatase"
GO:0120108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-3'pp5'G guanylate hydrolase
GO:0120108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-3'-diphospho-5'-guanosine diphosphatase
GO:0120108	skos:altLabel	"aprataxin"
GO:0120108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)
REACT:R-DRE-1296043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of HCN channels (Danio rerio)
RHEA:22612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-citramalyl-CoA lyase"
RHEA:22612	skos:altLabel	"citramalyl-CoA lyase"
RHEA:22612	skos:altLabel	"(3S)-citramalyl-CoA pyruvate-lyase"
RHEA:22612	skos:prefLabel	"(S)-citramalyl-CoA lyase"
RHEA:22612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA = acetyl-CoA + pyruvate
REACT:R-XTR-193711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
REACT:R-MTU-879273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycothiol conjugates with electrophilic xenobiotic (Mycobacterium tuberculosis)
REACT:R-MMU-6814695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PERP binds desmosomes (Mus musculus)
REACT:R-CFA-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Canis familiaris)
REACT:R-XTR-8874082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates PTK2 (Xenopus tropicalis)
REACT:R-CFA-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
REACT:R-BTA-5691507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPA deacetylates NAA to acetate and L-aspartate (Bos taurus)
GO:0050024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity
GO:0050024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-galactono-1,4-lactone oxidase activity
GO:0050024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-xylono-1,4-lactone oxidase activity
GO:0050024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactonolactone oxidase activity
REACT:R-SSC-9603982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeA to form LeB (Sus scrofa)
REACT:R-CFA-5632738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDIT4 binds 14-3-3 dimer (Canis familiaris)
RHEA:17397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH
RHEA:17397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxoacyl-[acyl-carrier-protein] reductase"
RHEA:17397	skos:prefLabel	"3-oxoacyl-[acyl-carrier-protein] reductase"
REACT:R-BTA-450984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Bos taurus)
REACT:R-HSA-4641134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds AXIN (Homo sapiens)
REACT:R-GGA-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Gallus gallus)
REACT:R-CFA-204981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3epsilon attentuates NADE-related apoptosis (Canis familiaris)
REACT:R-DRE-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-HSA-5656438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALDOB does not cleave Fru 1-P to GA and DHAP (Homo sapiens)
REACT:R-RNO-5653786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 deISGylates ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
REACT:R-RNO-2404195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Rattus norvegicus)
REACT:R-CEL-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
RHEA:15588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 4 A <=> 4 AH2 + all-trans-lycopene
RHEA:40713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate => 1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol
RHEA:11066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 1,6-bisphosphate + H2O
RHEA:29008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + Mn(2+)(in) => H(+)(out) + Mn(2+)(out)
REACT:R-BTA-1295622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds CBL (Bos taurus)
RHEA:71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + H(+)(out) <=> Ca(2+)(out) + H(+)(in)
REACT:R-BTA-8871373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMX phosphorylates RUFY1 (Bos taurus)
REACT:R-DRE-8848355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes retinyl palmitate (Danio rerio)
REACT:R-MMU-159566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Mus musculus)
REACT:R-DME-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Drosophila melanogaster)
GO:0047604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylmethylcarbinol racemase activity
GO:0047604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin racemase activity
REACT:R-BTA-9012036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)
REACT:R-BTA-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Bos taurus)
REACT:R-HSA-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Homo sapiens)
RHEA:72346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol
RHEA:38186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + H2O <=> dGMP + diphosphate + H(+)
RHEA:34311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol + NADH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite
RHEA:54404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
REACT:R-GGA-205328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other tyrosine kinases with p-KIT (Gallus gallus)
GO:0018679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene-5,5-dioxide monooxygenase activity
REACT:R-DME-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Drosophila melanogaster)
REACT:R-XTR-158756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Xenopus tropicalis)
REACT:R-MMU-2454113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 transports 11cRAL to rod photoreceptor outer segment (Mus musculus)
REACT:R-BTA-5686900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 recruits DCLRE1C to ATM (Bos taurus)
REACT:R-CFA-168405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD oligomer recruites RIP2 (RICK) (Canis familiaris)
RHEA:68911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + picolinate <=> AMP + diphosphate + NADP(+) + picolinal
REACT:R-SSC-193695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK interacts with TRAF6 (Sus scrofa)
RHEA:42713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(54) in tRNA => 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:56852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reumycin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toxoflavin
REACT:R-SSC-75879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Sus scrofa)
REACT:R-DRE-381503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP6 binds IGF forming IGF:IGFBP6 (Danio rerio)
REACT:R-DDI-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Dictyostelium discoideum)
REACT:R-HSA-1250498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. (Homo sapiens)
RHEA:43322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin
GO:0030738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-methionine:tyramine N-methyltransferase activity
GO:0030738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyramine methylpherase activity
GO:0030738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyramine N-methyltransferase activity
GO:0030738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)
GO:0030738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tyramine N-methyltransferase activity
RHEA:61971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-GGA-5676592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xRANK binds RANKL,sRANKL trimer:RANK (Gallus gallus)
RHEA:48823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
REACT:R-DRE-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Danio rerio)
RHEA:33375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + H(+) + NADPH = a 1-acyl-sn-glycero-3-phosphate + NADP(+)
REACT:R-DRE-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Danio rerio)
RHEA:20731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)
REACT:R-CFA-9793679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)
REACT:R-BTA-200326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CK octamer] (Bos taurus)
REACT:R-RNO-190682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin synthesis (generic) (Rattus norvegicus)
REACT:R-DRE-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Danio rerio)
REACT:R-BTA-174587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Bos taurus)
REACT:R-CFA-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Canis familiaris)
RHEA:65722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + CO2 + H(+) + succinate + sulfate => 2-oxoglutarate + butyl sulfate + O2
REACT:R-SSC-1605768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Sus scrofa)
REACT:R-MMU-389652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Mus musculus)
GO:1990644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule site clamp
REACT:R-DRE-5607732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TAK1 autophosphorylates (Danio rerio)
REACT:R-DRE-211206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of DFF to the nucleus (Danio rerio)
REACT:R-XTR-2395257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-hydroxylysino-norleucine cross-links (Xenopus tropicalis)
RHEA:56121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)
RHEA:20995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxytabersonine + S-adenosyl-L-methionine <=> 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine
RHEA:64561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-ol + NAD(+) => butan-2-one + H(+) + NADH
RHEA:21474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citryl-CoA + ADP + phosphate => ATP + citrate + CoA
REACT:R-BTA-6803719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds ZNF385A (Bos taurus)
RHEA:50405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] => 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]
GO:0050359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tropomyosin kinase activity
GO:0050359	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:tropomyosin O-phosphotransferase activity
GO:0050359	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tropomyosin kinase (phosphorylating) activity
GO:0050359	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK
RHEA:36793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyurea + L-ornithine => H2O + N(omega)-hydroxy-L-arginine
RHEA:31461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
REACT:R-HSA-204949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRIF and TRAF6 may activate JNK (Homo sapiens)
REACT:R-GGA-5658438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRED dimer binds NF1 (Gallus gallus)
REACT:R-CEL-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)
RHEA:51451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Bos taurus)
RHEA:26533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O
REACT:R-HSA-9670014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor VIIIa dissociates  (Homo sapiens)
REACT:R-HSA-187688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Homo sapiens)
REACT:R-DRE-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)
REACT:R-SSC-433104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACT co-transports trivalent citrate and a sodium ion (Sus scrofa)
REACT:R-CEL-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Caenorhabditis elegans)
GO:0047053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)
GO:0047053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cheilanthifoline synthase activity
GO:0047053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity
REACT:R-RNO-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Rattus norvegicus)
REACT:R-PFA-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Plasmodium falciparum)
REACT:R-GGA-1306969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)
EC:2.7.2.-	skos:prefLabel	"Phosphotransferases with a carboxy group as acceptor"
EC:2.7.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphotransferases with a carboxy group as acceptor"
REACT:R-BTA-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
REACT:R-SSC-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Sus scrofa)
REACT:R-GGA-9611852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB3 bind ADR,NAd (Gallus gallus)
RHEA:34772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) => a 3-oxosteroid + CO2 + NADPH
RHEA:57720	skos:altLabel	"ATP synthase"
RHEA:57720	skos:altLabel	"F1-ATPase"
RHEA:57720	skos:prefLabel	"H(+)-transporting two-sector ATPase"
RHEA:57720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate
RHEA:57720	skos:altLabel	"F0F1-ATPase"
RHEA:57720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"H(+)-transporting two-sector ATPase"
RHEA:57720	skos:altLabel	"H(+)-transporting ATP synthase"
RHEA:57720	skos:altLabel	"mitochondrial ATPase"
RHEA:57720	skos:altLabel	"H(+)-transporting ATPase"
RHEA:57720	skos:altLabel	"FoF1-ATPase"
RHEA:57720	skos:altLabel	"chloroplast ATPase"
REACT:R-CEL-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Caenorhabditis elegans)
REACT:R-HSA-5696807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)
RHEA:28215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + prostaglandin H2 => [thioredoxin]-disulfide + prostaglandin F2alpha
RHEA:24403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UMP <=> ADP + UDP
RHEA:45081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine => ADP + dapdiamide E + H(+) + phosphate
RHEA:17259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine => O2 + reduced [NADPH--hemoprotein reductase] + vinorine
RHEA:53926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine => a secondary amine + S-adenosyl-L-methionine
RHEA:13806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-5alpha-steroid => a 3-oxo-Delta(4)-steroid + AH2
RHEA:53357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20b) in tRNA + NADP(+) => H(+) + NADPH + uridine(20b) in tRNA
RHEA:50696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-8851436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFHR dimers bind C3b (Canis familiaris)
RHEA:59583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester
RHEA:24555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH
RHEA:15193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dGTPase"
RHEA:15193	skos:altLabel	"Deoxyguanosinetriphosphate triphosphohydrolase"
RHEA:15193	skos:altLabel	"deoxy-GTPase"
RHEA:15193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + H2O = 2'-deoxyguanosine + H(+) + triphosphate
RHEA:15193	skos:prefLabel	"dGTPase"
RHEA:42082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + 2 H(+) + NADH => all-trans-retinal + H2O + NAD(+)
REACT:R-XTR-432237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Xenopus tropicalis)
REACT:R-XTR-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Xenopus tropicalis)
RHEA:23126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + D-ribulose 1,5-bisphosphate + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)
REACT:R-CEL-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)
RHEA:18760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> CO2 + cylindrospermopsin + succinate
REACT:R-XTR-433089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT can transport taurolithocholate-3-sulphate (Xenopus tropicalis)
REACT:R-RNO-9611839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β3-agonists bind ADRB3 (Rattus norvegicus)
RHEA:67103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumigatonoid B <=> fumigatonoid C
RHEA:44504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate
EC:1.6.1.3	skos:altLabel	"pyridine nucleotide transferase"
EC:1.6.1.3	skos:altLabel	"NADPH-NAD(+) transhydrogenase"
EC:1.6.1.3	skos:altLabel	"pyridine nucleotide transhydrogenase"
EC:1.6.1.3	skos:altLabel	"nicotinamide nucleotide transhydrogenase"
EC:1.6.1.3	skos:altLabel	"NADH-NADP(+)-transhydrogenase"
EC:1.6.1.3	skos:altLabel	"NADPH-NAD(+) oxidoreductase"
EC:1.6.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(P)(+) transhydrogenase"
EC:1.6.1.3	skos:altLabel	"NAD(+) transhydrogenase"
EC:1.6.1.3	skos:prefLabel	"NAD(P)(+) transhydrogenase"
EC:1.6.1.3	skos:altLabel	"NADH transhydrogenase"
REACT:R-SSC-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Sus scrofa)
REACT:R-RNO-217255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO1:FAD N-oxidises TAM (Rattus norvegicus)
REACT:R-CEL-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Caenorhabditis elegans)
REACT:R-BTA-3108209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO1 (Bos taurus)
RHEA:14776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 NADPH + palmatine + S-adenosyl-L-methionine <=> corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine
RHEA:68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (1S,2S,4R)-beta-elemene + diphosphate
REACT:R-HSA-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Homo sapiens)
REACT:R-XTR-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Xenopus tropicalis)
EC:2.3.2.27	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RING-type E3 ubiquitin transferase"
EC:2.3.2.27	skos:altLabel	"ubiquitin transferase RING E3"
EC:2.3.2.27	skos:altLabel	"RING E3 ligase"
EC:2.3.2.27	skos:prefLabel	"RING-type E3 ubiquitin transferase"
REACT:R-MMU-1592387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin binds elastic fibres (Mus musculus)
REACT:R-CFA-429815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation Of Bloc-1 Complex (Canis familiaris)
REACT:R-RNO-8874745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Rattus norvegicus)
RHEA:70821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoarginine(out) + L-ornithine(in) => L-homoarginine(in) + L-ornithine(out)
RHEA:57345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-D-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-1614605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is dioxygenated (Caenorhabditis elegans)
REACT:R-SSC-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Sus scrofa)
RHEA:14948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP
RHEA:68478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty aldehyde + CO2 + H2O => a (2R)-2-hydroperoxy fatty acid + H(+)
REACT:R-DME-170846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 recruits TGFBR1 (Drosophila melanogaster)
REACT:R-RNO-1462003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNP1-4 are stored in primary neutrophil granules (Rattus norvegicus)
REACT:R-GGA-8939688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) complex binds RUNX2 (Gallus gallus)
RHEA:25442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-BTA-5696146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC2 deaminates TYR (Bos taurus)
REACT:R-XTR-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Xenopus tropicalis)
RHEA:21332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosamine N-acetyltransferase"
RHEA:21332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-glucosamine = CoA + H(+) + N-acetyl-D-glucosamine
RHEA:21332	skos:prefLabel	"glucosamine N-acetyltransferase"
RHEA:21332	skos:altLabel	"glucosamine acetylase"
RHEA:45478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine
REACT:R-CFA-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
REACT:R-HSA-982765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone forms dimers and oligomers (Homo sapiens)
REACT:R-BTA-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Bos taurus)
RHEA:47534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => chenodeoxycholate + NAD(+)
REACT:R-RNO-159050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Rattus norvegicus)
REACT:R-GGA-388811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-1 homodimer (Gallus gallus)
REACT:R-DRE-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Danio rerio)
REACT:R-RNO-158419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Rattus norvegicus)
REACT:R-BTA-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Bos taurus)
REACT:R-HSA-9022359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2:SIN3A complex binds GRIA2 gene promoter (Homo sapiens)
RHEA:45680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)
REACT:R-XTR-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Xenopus tropicalis)
RHEA:67814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-MMU-193101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11A1 cleaves 20a,22b-DHCHOL (Mus musculus)
RHEA:64359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 <=> (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O
RHEA:64409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out) => H(+)(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in)
REACT:R-SSC-9708525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1:FBXL17 binds SCF(SKP2) complex (Sus scrofa)
REACT:R-DRE-8853762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET dimerizes (Danio rerio)
RHEA:67582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate => 3'-phosphoadenylyl sulfate + tauro-alpha-muricholate
REACT:R-MMU-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Mus musculus)
REACT:R-HSA-9685195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 9b recruits ITCH to MAVS  (Homo sapiens)
RHEA:53490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+) => 11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH
RHEA:41960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GA1 (d18:1(4E)) + H(+) + UDP
RHEA:25213	skos:prefLabel	"UDP-2,3-diacylglucosamine diphosphatase"
RHEA:25213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP
RHEA:25213	skos:altLabel	"UDP-2,3-diacylglucosamine pyrophosphatase"
RHEA:25213	skos:altLabel	"UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate phosphohydrolase"
RHEA:25213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O = a lipid X + 2 H(+) + UMP
RHEA:25213	skos:altLabel	"UDP-2,3-diacylglucosamine hydrolase"
RHEA:25213	skos:altLabel	"UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine diphosphatase"
RHEA:25213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-2,3-diacylglucosamine diphosphatase"
REACT:R-RNO-2029268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of PLCG (Rattus norvegicus)
REACT:R-MMU-8879117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT2 transfers GlcNAc to Man-DAG1 (Mus musculus)
RHEA:56270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
RHEA:59080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)
REACT:R-CFA-8987156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Canis familiaris)
RHEA:39486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)
REACT:R-MMU-76496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Mus musculus)
REACT:R-BTA-193684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 recruits an atypical PKC (Bos taurus)
REACT:R-CFA-8854897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Canis familiaris)
REACT:R-MMU-8874685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds MET (Mus musculus)
RHEA:23417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-O-phospho-3-sulfolactate + H2O => (2R)-3-sulfolactate + phosphate
REACT:R-RNO-8952371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds RUNX3 (Rattus norvegicus)
RHEA:23993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA
RHEA:35234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin(in) <=> rifampicin(out)
RHEA:60014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA with a 3' CCA end + diphosphate => a tRNA with a 3' CC end + ATP
REACT:R-XTR-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Xenopus tropicalis)
RHEA:45671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
RHEA:55419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biochanin A + UDP-alpha-D-glucose <=> biochanin A 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-GGA-1022133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Gallus gallus)
EC:3.1.6.7	skos:prefLabel	"cellulose-polysulfatase"
EC:3.1.6.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellulose-polysulfatase"
REACT:R-GGA-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Gallus gallus)
GO:0047553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate synthase activity
GO:0047553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutarate synthase activity
GO:0047553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)
GO:0047553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate:ferredoxin oxidoreductase activity
GO:0047553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)
GO:0047553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KGOR activity
GO:0047553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ketoglutarate ferredoxin oxidoreductase activity
GO:0047553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate ferredoxin oxidoreductase activity
GO:0047553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutarate-ferredoxin oxidoreductase activity
REACT:R-XTR-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Xenopus tropicalis)
RHEA:23551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(966) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:56483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
RHEA:49763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDTA + FMNH2 + O2 <=> ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O
REACT:R-CEL-2002401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Caenorhabditis elegans)
REACT:R-SPO-4551648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO1 (Schizosaccharomyces pombe)
GO:0080062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokinin 9-beta-glucosyltransferase activity
REACT:R-CFA-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Canis familiaris)
RHEA:12692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 mycothiol + NAD(+) <=> H(+) + mycothione + NADH
REACT:R-MMU-396996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs binds G-protein Gq (Mus musculus)
RHEA:57005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + streptothricin D => CoA + H(+) + N(beta)-acetylstreptothricin D
REACT:R-XTR-1606583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Xenopus tropicalis)
REACT:R-CFA-5675206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEA15 binds MAPK monomers and dimers (Canis familiaris)
REACT:R-RNO-8987042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)
RHEA:54933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] => (2E,9Z)-hexadecadienoyl-[ACP] + H2O
GO:0047790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine deaminase activity
GO:0047790	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	creatinine desiminase activity
GO:0047790	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	creatinine iminohydrolase activity
GO:0047790	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	creatinine hydrolase
REACT:R-SSC-981814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC2 transfers sialic acid to Core 1 mucins (Sus scrofa)
RHEA:55324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA
REACT:R-RNO-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)
REACT:R-DRE-1606583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Danio rerio)
REACT:R-HSA-9694529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquination of protein E (Homo sapiens)
REACT:R-HSA-266012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTD4 is converted to LTE4 by DPEP1/2 (Homo sapiens)
REACT:R-RNO-1112727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serine phosphorylation of STATs (Rattus norvegicus)
REACT:R-HSA-879584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO3A1 isoform 1 has abroad substrate specificity (Homo sapiens)
REACT:R-DRE-2176475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Danio rerio)
REACT:R-MMU-2090037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(6) (Mus musculus)
RHEA:60075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 <=> 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)
RHEA:31021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O => 4 AH2 + all-trans-4,4'-diapolycopene + 4 O2
REACT:R-CFA-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Canis familiaris)
GO:0050645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonoid glucosyltransferase activity
GO:0050645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	limonoid UDP-glucosyltransferase activity
GO:0050645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-limonoid glucosyltransferase activity
GO:0050645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LGTase activity
REACT:R-DRE-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Danio rerio)
REACT:R-SSC-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Sus scrofa)
REACT:R-HSA-1793217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase (Homo sapiens)
REACT:R-HSA-5658438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRED dimer binds NF1 (Homo sapiens)
REACT:R-DRE-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Danio rerio)
RHEA:48420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1 (d18:1(4E)) + H(+)
REACT:R-GGA-9023884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to TGFA promoter (Gallus gallus)
RHEA:65482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexyl 2-methylbutanoate => 2-methylbutanoyl-CoA + hexan-1-ol
RHEA:33244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:31352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lupan-3beta,20-diol => (S)-2,3-epoxysqualene + H2O
RHEA:33856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphophytoceramide + GDP + H(+)
REACT:R-SSC-9718360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide agonists (Sus scrofa)
REACT:R-GGA-373129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + FADH2 <=> succinate + FAD (Gallus gallus)
REACT:R-MMU-176631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Mus musculus)
REACT:R-MMU-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Mus musculus)
REACT:R-BTA-69562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Bos taurus)
REACT:R-DME-8863718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGFG1 binds VAMP7 (Drosophila melanogaster)
REACT:R-SCE-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Saccharomyces cerevisiae)
REACT:R-XTR-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Xenopus tropicalis)
RHEA:64934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + 2 H(+) + 2 phosphate => dGTP + 2 H2O
REACT:R-DME-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Drosophila melanogaster)
RHEA:28963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-proline(out) = H(+)(in) + L-proline(in)
RHEA:34145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(9)-tetrahydrocannabinolate + H2O2 => cannabinerolate + O2
REACT:R-CFA-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Canis familiaris)
RHEA:18538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + salicylaldehyde => 2 H(+) + NADH + salicylate
RHEA:44368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cr(6+) + 2 NADPH + O2 = Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide
REACT:R-BTA-9688832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PDCD6IP and SDCBP (Bos taurus)
REACT:R-SSC-1855197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)
RHEA:56933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH
REACT:R-RNO-216058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Rattus norvegicus)
REACT:R-GGA-2168887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Albumin to Hemopexin (Gallus gallus)
RHEA:59672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotriose + O2 = D-maltotriono-1,5-lactone + H2O2
REACT:R-DME-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Drosophila melanogaster)
RHEA:31256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate
RHEA:17081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-isoeugenol = H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol
RHEA:15993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)
REACT:R-RNO-8851979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL9 binds immune cell surfaces (Rattus norvegicus)
REACT:R-BTA-1475025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Bos taurus)
RHEA:46670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrodeoxycorticosterone + NADP(+) => 21-hydroxyprogesterone + H(+) + NADPH
GO:0030339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acyl-ethyl-ester synthase activity
GO:0030339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAEE synthase activity
GO:0030339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-fatty-acyl-ethyl-ester acylhydrolase activity
GO:0030339	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAEES activity
GO:0030339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acyl ethyl ester synthase
REACT:R-SSC-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Sus scrofa)
RHEA:49428	skos:prefLabel	"phosphonoformate cytidylyltransferase"
RHEA:49428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphonoformate cytidylyltransferase"
RHEA:49428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate
RHEA:62462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein]
REACT:R-MMU-202174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ZAP-70 (Mus musculus)
GO:0050149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminophenol:O2 oxidoreductase activity
GO:0050149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	o-aminophenol oxidase activity
GO:0050149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminophenol:oxygen oxidoreductase activity
GO:0050149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-aminophenol:O2 oxidoreductase activity
GO:0050149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GriF
GO:0050149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isophenoxazine synthase activity
REACT:R-DME-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Drosophila melanogaster)
REACT:R-GGA-5654620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)
REACT:R-HSA-9033516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
REACT:R-HSA-6811412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer to the Golgi (Homo sapiens)
REACT:R-MMU-9701507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN6 dephosphorylates JAK3 (Mus musculus)
REACT:R-CFA-2404195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Canis familiaris)
REACT:R-SCE-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Saccharomyces cerevisiae)
RHEA:39334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)
RHEA:20889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+)
REACT:R-CFA-1250189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Canis familiaris)
RHEA:28980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + nitrite(in) => H(+)(in) + nitrite(out)
RHEA:50017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine
RHEA:40054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate <=> 3-[(1-carboxyvinyl)-oxy]benzoate + H2O
RHEA:28394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-Ala-D/L-Glu epimerase"
RHEA:28394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-L-glutamate = L-alanyl-D-glutamate
RHEA:28394	skos:altLabel	"AE epimerase"
RHEA:28394	skos:prefLabel	"L-Ala-D/L-Glu epimerase"
REACT:R-GGA-140847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Gallus gallus)
REACT:R-DME-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Drosophila melanogaster)
REACT:R-HSA-3239019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK5 (Homo sapiens)
REACT:R-BTA-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Bos taurus)
REACT:R-SSC-169895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk's SH3 domain engages C3G (Sus scrofa)
GO:0001067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription regulatory region nucleic acid binding
GO:0001067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	regulatory region nucleic acid binding
REACT:R-SSC-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Sus scrofa)
REACT:R-GGA-1234164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Gallus gallus)
REACT:R-HSA-202344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
REACT:R-HSA-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Homo sapiens)
REACT:R-BTA-976801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I complex formation (Bos taurus)
REACT:R-MMU-174741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Mus musculus)
RHEA:65440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
REACT:R-CFA-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Canis familiaris)
REACT:R-DME-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)
REACT:R-DME-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Drosophila melanogaster)
RHEA:72359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + succinate(out) = glutarate(out) + succinate(in)
REACT:R-CFA-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Canis familiaris)
REACT:R-DDI-5623643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH13 reduces atRAL to atROL (Dictyostelium discoideum)
REACT:R-RNO-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Rattus norvegicus)
REACT:R-PFA-8959510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPHS2 phosphorylates H2Se to form SELP (Plasmodium falciparum)
REACT:R-SSC-5686440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81:EME1,EME2 cleaves D-loop (Sus scrofa)
REACT:R-DRE-2130349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Generation of CLIP from lip10 (Danio rerio)
RHEA:52578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA + H(+) + NADH => hexanoyl-CoA + NAD(+)
RHEA:64833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + benzoyl-CoA => 3-hydroxy-benzyl benzoate + CoA
REACT:R-DRE-8939323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 binds BCL10 and Ubiquitin:E2 (Danio rerio)
RHEA:35943	skos:prefLabel	"brevianamide F prenyltransferase (deoxybrevianamide E-forming)"
RHEA:35943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brevianamide F + dimethylallyl diphosphate = deoxybrevianamide E + diphosphate
RHEA:35943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"brevianamide F prenyltransferase (deoxybrevianamide E-forming)"
RHEA:35943	skos:altLabel	"brevianamide F reverse prenyltransferase"
REACT:R-HSA-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Homo sapiens)
REACT:R-CFA-2213248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of antigen loaded MHC II molecules to surface (Canis familiaris)
RHEA:58733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-CTP + H2O => 5-methyl-CMP + diphosphate + H(+)
REACT:R-RNO-5649802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)
RHEA:67486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O
REACT:R-RNO-1358791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of USP8 by P-AKT (Rattus norvegicus)
GO:0016810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on carbon-nitrogen bonds, other than peptide bonds"
GO:0016810	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds
GO:0016810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016810	skos:prefLabel	"Acting on carbon-nitrogen bonds, other than peptide bonds"
GO:0016810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAAA hydrolyses NAEs to FAs and ethanolamine (Homo sapiens)
REACT:R-MMU-212007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1 4-hydroxylate atRA (Mus musculus)
RHEA:32987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol
REACT:R-RNO-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Rattus norvegicus)
RHEA:43546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + gamma-L-glutamyltyramine + H(+) + phosphate => ATP + L-glutamate + tyramine
RHEA:44787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-10 + S-adenosyl-L-methionine <=> H(+) + menaquinol-10 + S-adenosyl-L-homocysteine
RHEA:39032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP
RHEA:63089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Danio rerio)
GO:0035379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon dioxide transmembrane transporter activity
REACT:R-DRE-139899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of BAD protein by 14-3-3 (Danio rerio)
REACT:R-GGA-2730856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Gallus gallus)
REACT:R-HSA-418874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
RHEA:64936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + H2O = dGDP + H(+) + phosphate
REACT:R-CEL-374922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenalin synaptic vesicle docking and priming (Caenorhabditis elegans)
GO:0018625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	naphthalene dioxygenase activity
GO:0018625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	naphthalene oxygenase activity
GO:0018625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthalene 1,2-dioxygenase activity
GO:0018625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
RHEA:24934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteine <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate
REACT:R-BTA-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Bos taurus)
REACT:R-GGA-5638012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D dissociates from ARL13B:INPP5E (Gallus gallus)
REACT:R-RNO-446701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4-activated IRAK1 autophosphorylates (Rattus norvegicus)
REACT:R-XTR-388863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Xenopus tropicalis)
RHEA:55679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + NH4(+) <=> (2S)-2-amino-4-deoxychorismate + H2O
REACT:R-DRE-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Danio rerio)
RHEA:62189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate => diphosphate + syn-isopimara-7,15-diene
REACT:R-SPO-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Schizosaccharomyces pombe)
REACT:R-MMU-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Mus musculus)
REACT:R-DRE-9014424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the phagocytic vesicle membrane (Danio rerio)
REACT:R-MMU-5690988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-incision of DNA by ERCC5 (XPG) in GG-NER (Mus musculus)
REACT:R-XTR-1564142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV degradation by MMP2,3,4,9,10,12 (Xenopus tropicalis)
RHEA:35705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH + O2
RHEA:45016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine = L-selenomethionine + tetrahydropteroyltri-L-glutamate
REACT:R-DME-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Drosophila melanogaster)
GO:0061797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pH-gated chloride channel activity
RHEA:13046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:27324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Dictyostelium discoideum)
REACT:R-BTA-1678841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Bos taurus)
REACT:R-CFA-111751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)
REACT:R-DDI-8948015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Dictyostelium discoideum)
RHEA:55646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate => ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein]
REACT:R-MMU-937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 (Mus musculus)
REACT:R-RNO-5357479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AXL binds PI3K (Rattus norvegicus)
REACT:R-HSA-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)
RHEA:65731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + hexyl sulfate + O2 <=> CO2 + H(+) + hexanal + succinate + sulfate
RHEA:44286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octanoyl-CoA
RHEA:34751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acyl-15-methylhexadecasphing-4-enine = ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate
REACT:R-HSA-9006585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN4 gene expression is stimulated by MECP2 (Homo sapiens)
REACT:R-CFA-5661123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate Me2K5-histone H3 (Canis familiaris)
RHEA:13772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NAD(+) <=> dihydroxyacetone + H(+) + NADH
RHEA:49479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-1-piperideine-6-carboxylate + NAD(+) <=> H(+) + L-2-aminoadipate + NADH
RHEA:69993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH => 3-dehydro-6-deoxoteasterone + NADP(+)
REACT:R-DRE-1678742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses Heparan sulfate chain(4) (Danio rerio)
GO:0034908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity
REACT:R-BTA-422104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase octanoylates Proghrelin (Bos taurus)
REACT:R-BTA-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Bos taurus)
REACT:R-CFA-187545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cks1 with SCF(Skp2) complex (Canis familiaris)
REACT:R-GGA-8876366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL translocates from endosome lumen to lysosome lumen (Gallus gallus)
RHEA:48859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 <=> (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O
RHEA:66522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-RNO-6803875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds CDK1 and CCNB1 (Rattus norvegicus)
REACT:R-DRE-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Danio rerio)
GO:0050612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenate:acceptor oxidoreductase activity
GO:0050612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenate:(acceptor) oxidoreductase activity
GO:0050612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate reductase (donor) activity
GO:0050612	skos:prefLabel	"arsenate reductase (donor)"
GO:0050612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + arsenite + H2O = AH2 + arsenate + H(+)
GO:0050612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arsenate reductase (donor)"
REACT:R-HSA-9636251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPE2 binds KPNA1:KPNB1 (Homo sapiens)
RHEA:53299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + NADP(+) <=> (2E,4E)-decadienoyl-CoA + H(+) + NADPH
GO:0008967	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P-glycolate phosphatase activity
GO:0008967	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phosphoglycolate phosphatase activity
GO:0008967	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglycolate hydrolase activity
GO:0008967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglycolate phosphatase"
GO:0008967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglycolate phosphatase activity
GO:0008967	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglycollate phosphatase activity
GO:0008967	skos:prefLabel	"phosphoglycolate phosphatase"
GO:0008967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phosphoglycolate + H2O = glycolate + phosphate
GO:0008967	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phosphoglycolate phosphohydrolase activity
RHEA:67554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholate
RHEA:17862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone => 20-hydroxy-3-oxopregn-4-en-21-al
REACT:R-BTA-5358599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Bos taurus)
RHEA:52120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate
REACT:R-CFA-193099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)
RHEA:50994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thromboxane B2(in) => thromboxane B2(out)
REACT:R-HSA-5340251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)
REACT:R-SSC-76397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Sus scrofa)
REACT:R-BTA-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Bos taurus)
RHEA:35151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) = (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH
RHEA:43565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine => [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate
REACT:R-CEL-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Caenorhabditis elegans)
RHEA:59861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP
RHEA:58918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene
RHEA:64623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + acetyl-CoA <=> (E)-sinapoyl actetate + CoA
RHEA:56463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine
REACT:R-SSC-9773803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKBKB phosphorylates NF-kappa-B inhibitor  (Sus scrofa)
REACT:R-CFA-73598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Canis familiaris)
EC:4.4.1.1	skos:altLabel	"homoserine deaminase"
EC:4.4.1.1	skos:altLabel	"cystathionase"
EC:4.4.1.1	skos:altLabel	"cystathioninase"
EC:4.4.1.1	skos:altLabel	"homoserine dehydratase"
EC:4.4.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cystathionine gamma-lyase"
EC:4.4.1.1	skos:altLabel	"cystine desulfhydrase"
EC:4.4.1.1	skos:altLabel	"cysteine desulfhydrase"
EC:4.4.1.1	skos:altLabel	"gamma-cystathionase"
EC:4.4.1.1	skos:prefLabel	"cystathionine gamma-lyase"
REACT:R-HSA-199093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXADR binds to AMICA1 (Homo sapiens)
EC:2.7.8.43	skos:prefLabel	"lipid A phosphoethanolamine transferase"
EC:2.7.8.43	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipid A phosphoethanolamine transferase"
EC:2.7.8.43	skos:altLabel	"lipid A PEA transferase"
RHEA:21203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysine <=> (S)-2-amino-6-oxohexanoate + L-glutamate
REACT:R-DRE-141422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 converted  to an inhibitory state via interaction with Mad1 (Danio rerio)
RHEA:64659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapaldehyde + CoA + NADP(+) <=> (E)-sinapoyl-CoA + H(+) + NADPH
REACT:R-CFA-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Canis familiaris)
REACT:R-RNO-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Rattus norvegicus)
GO:0102902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopimaradienal hydroxylase activity
REACT:R-GGA-5649658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves DHU from damaged DNA (Gallus gallus)
RHEA:72087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurodeoxycholate(out) = 2 Na(+)(in) + taurodeoxycholate(in)
RHEA:40010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O <=> (+)-copalol + diphosphate
RHEA:32332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-endo-fenchol + NAD(+) => (1S,4R)-fenchone + H(+) + NADH
REACT:R-BTA-5668481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protesomal degradation of K48polyUb-TRAF3 (Bos taurus)
REACT:R-XTR-444647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3a receptor binds anaphylatoxin C3a (Xenopus tropicalis)
GO:0015130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mevalonate transmembrane transporter activity
GO:0015130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
REACT:R-HSA-442832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK phosphorylates cortactin (Homo sapiens)
REACT:R-RNO-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Rattus norvegicus)
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phospho-5'-S-methylthioribose isomerase activity
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
GO:0046523	skos:altLabel	"S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase"
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-methyl-5-thioribose-1-phosphate isomerase"
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-PMTR isomerase activity
GO:0046523	skos:altLabel	"MTR-1-P isomerase"
GO:0046523	skos:altLabel	"1-PMTR isomerase"
GO:0046523	skos:altLabel	"S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase"
GO:0046523	skos:altLabel	"methylthioribose 1-phosphate isomerase"
GO:0046523	skos:altLabel	"5-methylthioribose-1-phosphate isomerase"
GO:0046523	skos:prefLabel	"S-methyl-5-thioribose-1-phosphate isomerase"
GO:0046523	skos:altLabel	"5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase"
GO:0046523	skos:altLabel	"1-phospho-5'-S-methylthioribose isomerase"
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylthioribose 1-phosphate isomerase activity
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thioribose-1-phosphate isomerase activity
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MTR-1-P isomerase activity
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity
GO:0046523	skos:altLabel	"S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase"
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity
GO:0046523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylthioribose-1-phosphate isomerase activity
RHEA:24661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine + NADPH + O2 => H2O + N(omega)-hydroxy-L-arginine + NADP(+)
REACT:R-MMU-5654692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
RHEA:56508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP
RHEA:12915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoyl-5'-AMP + diphosphate => (R)-lipoate + ATP + H(+)
REACT:R-SCE-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)
REACT:R-SSC-375330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 45/Connexin 36 mediated neuronal gap junction communication (Sus scrofa)
REACT:R-HSA-9762100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYC- and NICD1-dependent NFE2L2 gene expression (Homo sapiens)
REACT:R-MMU-1467269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins bind microbial membranes causing disruption (Mus musculus)
REACT:R-DRE-1254248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80:YAP1 complex to the nucleus (Danio rerio)
REACT:R-CFA-981809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Canis familiaris)
RHEA:52723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O <=> 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)
GO:0102352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidate kinase activity
REACT:R-MMU-5686430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81 binds EME1, EME2 (Mus musculus)
RHEA:33490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA <=> CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine
REACT:R-BTA-159762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)
REACT:R-SSC-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Sus scrofa)
RHEA:71539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + 2 nitrate(out) = H(+)(in) + 2 nitrate(in)
REACT:R-RNO-9632038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)
RHEA:71254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylopyranose <=> L-xylulose
REACT:R-GGA-69299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds geminin (Gallus gallus)
REACT:R-CFA-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
RHEA:28659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-lactose + H2O = beta-D-galactose + beta-D-glucose
RHEA:66852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
RHEA:51902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + spermidine => H2O + N(1)-acetylspermidine
REACT:R-HSA-114563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
REACT:R-XTR-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Xenopus tropicalis)
REACT:R-SCE-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)
REACT:R-BTA-5362525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)
RHEA:10354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + an aralkylamine => an N-acetylarylalkylamine + H2O
REACT:R-BTA-1675473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B binds JAK2 (Bos taurus)
RHEA:65520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]
RHEA:48562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + N(6)-dimethylallyladenine => H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate
REACT:R-GGA-2022378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Gallus gallus)
REACT:R-SSC-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Sus scrofa)
RHEA:10913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + AMP + diphosphate + H(+)
REACT:R-GGA-8953013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 binds E2F8 (Gallus gallus)
RHEA:37007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA
RHEA:29434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + phosphate <=> ADP + diphosphate
REACT:R-MMU-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Mus musculus)
RHEA:34729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine + a carboxylate => H2O + N-acyl-15-methylhexadecasphinganine
RHEA:46010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + pentanoyl-CoA => CoA + NAD(+) + pentanal
GO:0044606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphocholine hydrolase activity
GO:0102349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-lignocero-2-enoyl-CoA reductase activity
GO:0030749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:loganic acid methyltransferase activity
GO:0030749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loganate O-methyltransferase activity
GO:0030749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	loganate methyltransferase activity
GO:0030749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loganate + S-adenosyl-L-methionine = loganin + S-adenosyl-L-homocysteine
GO:0030749	skos:prefLabel	"loganate O-methyltransferase"
GO:0030749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity
GO:0030749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"loganate O-methyltransferase"
RHEA:40863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + heptadecanoyl-CoA = FADH2 + trans-2-heptadecenoyl-CoA
REACT:R-HSA-1467209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of defensins to lipid II (Homo sapiens)
REACT:R-DRE-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
RHEA:56743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + UDP-alpha-D-galactose <=> GalGb3Cer + H(+) + UDP
REACT:R-HSA-5600598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP11B2 does not oxidise 11DCORST (Homo sapiens)
RHEA:59546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + N,N'-diacetylchitobiono-1,5-lactone => N,N'-diacetylchitobiose + O2
RHEA:35193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + norsolorinic acid => noranthrone + O2
GO:0097001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide binding
RHEA:48048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + H2O = D-galactose + ganglioside GM2 (d18:1(4E))
REACT:R-MMU-9009936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEL cleaves cellular ssRNA (Mus musculus)
EC:1.14.2.-	skos:prefLabel	"With ascorbate as one donor"
EC:1.14.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With ascorbate as one donor"
RHEA:40549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-2168888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha1-Microglobulin binds heme (Gallus gallus)
REACT:R-BTA-549297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-MMU-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Mus musculus)
RHEA:36390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl adenylate + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + H(+)
REACT:R-XTR-8849900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs1-3 bind each other in cis interactions (Xenopus tropicalis)
RHEA:47102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + taurocholate => choloyl-CoA + taurine
REACT:R-RNO-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)
GO:0005170	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin TRKC receptor ligand
GO:0005170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotrophin TRKC receptor binding
RHEA:37062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA + L-threonylcarbamoyladenylate <=> AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA
RHEA:14750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate + O2 => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)
REACT:R-DRE-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Danio rerio)
REACT:R-SSC-8944232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XII (Sus scrofa)
REACT:R-GGA-1362485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GH (Gallus gallus)
REACT:R-XTR-420265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind IAPP(34-70) (Xenopus tropicalis)
REACT:R-DDI-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Dictyostelium discoideum)
RHEA:13505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + O2 = betaine aldehyde + H2O2
REACT:R-BTA-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Bos taurus)
REACT:R-DME-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Drosophila melanogaster)
RHEA:35497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + L-glutamate => H2O + N-(4-aminobenzoyl)-L-glutamate
GO:0023031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class Ib protein binding, via lateral surface
REACT:R-RNO-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Rattus norvegicus)
REACT:R-XTR-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Xenopus tropicalis)
RHEA:58869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-HSA-9759356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent GSTA3 gene expression (Homo sapiens)
REACT:R-HSA-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Homo sapiens)
REACT:R-GGA-445448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHIP binds Hedgehog (Gallus gallus)
REACT:R-GGA-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Gallus gallus)
REACT:R-SSC-5658231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs stimulate RAS GTPase activity (Sus scrofa)
GO:0008518	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced folate carrier activity
GO:0008518	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced folate transporter
GO:0008518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate:anion antiporter activity
GO:0008518	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced folate transmembrane transporter activity
REACT:R-CEL-380574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine synaptic vesicle docking and priming (Caenorhabditis elegans)
RHEA:57198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + H(+) + L-cysteinyl-[protein] => H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]
RHEA:39700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-(13Z)-eicosenoyl-CoA => (2E,13Z)-eicosadienoyl-CoA + H2O
REACT:R-HSA-373730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin and NrCAM heterodimerization (Homo sapiens)
RHEA:34056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	festuclavine + NAD(+) => 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH
REACT:R-DRE-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Danio rerio)
REACT:R-HSA-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Homo sapiens)
RHEA:72759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A6 + malonyl-CoA = anthocyanin A8 + CoA
REACT:R-GGA-879907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate the receptor (Gallus gallus)
RHEA:10861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 => 2-(acetamidomethylene)succinate + NAD(+)
RHEA:27325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + inosine => 2'-deoxyguanosine + IMP
REACT:R-CFA-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)
REACT:R-SSC-444171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR2 binds carboxylates (Sus scrofa)
REACT:R-XTR-77321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Xenopus tropicalis)
RHEA:48135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl phosphate + H2O <=> (2E,6E)-farnesol + phosphate
RHEA:21442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain alkane + formate + H2O + 2 NADP(+) => a long-chain fatty aldehyde + H(+) + 2 NADPH + O2
REACT:R-MMU-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Mus musculus)
REACT:R-SSC-211924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4B1 12-hydroxylates ARA (Sus scrofa)
REACT:R-CFA-1855180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Canis familiaris)
REACT:R-HSA-3002811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)
RHEA:56031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
REACT:R-CFA-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Canis familiaris)
RHEA:30170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + dihydroxyacetone phosphate <=> D-sedoheptulose 1,7-bisphosphate
REACT:R-HSA-110250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenoadenine by MPG glycosylase (Homo sapiens)
REACT:R-CFA-71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Canis familiaris)
RHEA:10234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate => 5,6-dihydrouridine 5'-monophosphate + diphosphate
RHEA:15542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIMBOA + UDP-alpha-D-glucose => DIMBOA beta-D-glucoside + H(+) + UDP
REACT:R-XTR-5654157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR2 (Xenopus tropicalis)
REACT:R-XTR-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)
RHEA:65675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine
RHEA:33484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + ergosterol => CoA + ergosteryl ester
REACT:R-BTA-209063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Bos taurus)
GO:0102559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-(glutamine-N5) methyltransferase activity
RHEA:45601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)
REACT:R-SPO-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Schizosaccharomyces pombe)
REACT:R-SSC-3928601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 and PIP2 bind WASL, activating it (Sus scrofa)
RHEA:43979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + NADPH + O2 <=> 14-hydroxyhexadecanoate + H2O + NADP(+)
RHEA:21305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:30326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:17122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + L-lysine => H(+) + L-homocitrulline + phosphate
REACT:R-BTA-446200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLPP1 dephosphorylates DOLDP to DOLP (Bos taurus)
RHEA:69779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxindole-3-acetate + succinyl-CoA = (2-oxoindol-3-yl)acetyl-CoA + succinate
REACT:R-DME-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Drosophila melanogaster)
REACT:R-BTA-2186643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEN1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)
REACT:R-CFA-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Canis familiaris)
REACT:R-GGA-2203479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2 (FEEL-2) binds ligands (Gallus gallus)
REACT:R-SSC-1475414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Sus scrofa)
REACT:R-BTA-422021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Bos taurus)
RHEA:25168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexan-6-olide = 6-oxohexanoate + H(+)
REACT:R-CFA-1650808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Canis familiaris)
REACT:R-RNO-5637686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)
REACT:R-HSA-9704330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)
RHEA:60856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine
RHEA:42078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutaryl-CoA + acetate => 2-hydroxyglutarate + acetyl-CoA
REACT:R-SSC-187895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal C-ter TLR9 (Sus scrofa)
REACT:R-SCE-3780994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Saccharomyces cerevisiae)
GO:0031720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	haptoglobin binding
RHEA:15248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacylglycerol + H2O <=> a fatty acid + glycerol + H(+)
GO:0047149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylthetin-homocysteine methyltransferase activity
GO:0047149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity
GO:0047149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thetin-homocysteine methylpherase activity
GO:0047149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thetin-homocysteine S-methyltransferase activity
REACT:R-DDI-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Dictyostelium discoideum)
RHEA:37375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-SSC-9794008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC binds CFLAR (Sus scrofa)
REACT:R-SSC-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Sus scrofa)
RHEA:39320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)
GO:0030780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxydihydrochelirubine 12-O-methyltransferase activity
GO:0030780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity
RHEA:12399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-D-galactose + H2O + 2 NADP(+) <=> dTDP-D-galacturonate + 3 H(+) + 2 NADPH
REACT:R-CEL-3322019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-b (Caenorhabditis elegans)
RHEA:56694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2
REACT:R-DME-209341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMO by PKA-C1 (Drosophila melanogaster)
RHEA:32814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate(in) <=> benzoate(out)
REACT:R-DRE-374723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nociceptin receptor binds to nociceptin (Danio rerio)
RHEA:60020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene A
REACT:R-RNO-169905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS is phosphorylated by active TrkA receptor (Rattus norvegicus)
RHEA:16489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-prunasin + H2O = D-glucose + mandelonitrile
RHEA:16489	skos:prefLabel	"prunasin beta-glucosidase"
RHEA:16489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prunasin beta-glucosidase"
REACT:R-SSC-442368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
RHEA:35101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fusidate(out) + H(+)(in) => fusidate(in) + H(+)(out)
RHEA:49331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9621179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cinaciguat binds sGC:NO (Homo sapiens)
RHEA:28268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:68872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + ATP + H(+) + NADPH = (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)
REACT:R-CFA-4719423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO3 (Canis familiaris)
REACT:R-HSA-9621054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST binds the VGF promoter (Homo sapiens)
RHEA:66369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methyl-3,7-dioxodecanedioyl-CoA + CoA => 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA
REACT:R-CFA-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)
REACT:R-XTR-8849345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Xenopus tropicalis)
GO:0044105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylulose reductase (NAD+) activity
REACT:R-HSA-8874797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR gene expression is stimulated by TFAP2C (Homo sapiens)
REACT:R-XTR-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Xenopus tropicalis)
GO:0097260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to EXA4 by ALOX15 (Homo sapiens)
GO:0097260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eoxin A4 synthase activity
REACT:R-XTR-177934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR autophosphorylation (Xenopus tropicalis)
RHEA:14823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose => beta-L-arabinopyranose
REACT:R-SPO-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Schizosaccharomyces pombe)
REACT:R-SCE-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)
REACT:R-RNO-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)
RHEA:55775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonate + an L-alpha-amino acid + ATP <=> a jasmonyl-L-amino acid + AMP + diphosphate + H(+)
REACT:R-BTA-174105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated cell cycle proteins (Bos taurus)
REACT:R-XTR-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Xenopus tropicalis)
EC:3.4.21.6	skos:altLabel	"prothrombase"
EC:3.4.21.6	skos:altLabel	"prothrombinase"
EC:3.4.21.6	skos:prefLabel	"coagulation factor Xa"
EC:3.4.21.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coagulation factor Xa"
EC:3.4.21.6	skos:altLabel	"thrombokinase"
EC:3.4.21.6	skos:altLabel	"Stuart factor"
RHEA:51897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine => acetate + spermine
REACT:R-BTA-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Bos taurus)
REACT:R-BTA-6800380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAP-1 (Bos taurus)
REACT:R-RNO-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Rattus norvegicus)
REACT:R-BTA-174757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Bos taurus)
REACT:R-XTR-1602368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Xenopus tropicalis)
RHEA:46207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Gallus gallus)
REACT:R-XTR-8939688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) complex binds RUNX2 (Xenopus tropicalis)
RHEA:59255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate <=> (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA
RHEA:66569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O => preluffariellolide A
RHEA:33502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prephenate <=> 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2
REACT:R-DRE-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Danio rerio)
RHEA:54497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate => diphosphate + ent-atiserene
RHEA:15585	skos:prefLabel	"phytoene desaturase (lycopene-forming)"
RHEA:15585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phytoene desaturase (lycopene-forming)"
RHEA:15585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 4 A = 4 AH2 + all-trans-lycopene
RHEA:15585	skos:altLabel	"4-step phytoene desaturase"
RHEA:52420	skos:prefLabel	"S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)"
RHEA:52420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)"
RHEA:52420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-phospho-L-serine + thiosulfate = phosphate + S-sulfo-L-cysteine
REACT:R-BTA-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Bos taurus)
REACT:R-HSA-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Homo sapiens)
RHEA:48156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GQ1b (d18:1(4E)) + H2O = ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate
EC:3.1.13.-	skos:prefLabel	"Exoribonucleases producing 5'-phosphomonoesters"
EC:3.1.13.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Exoribonucleases producing 5'-phosphomonoesters"
RHEA:13209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 3 H2O + trithionate = AH2 + 4 H(+) + 3 sulfite
REACT:R-SPO-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Schizosaccharomyces pombe)
RHEA:53137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH
REACT:R-CEL-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Caenorhabditis elegans)
GO:0034791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutylamine N-hydroxylase activity
REACT:R-HSA-428127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Homo sapiens)
RHEA:30969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9'-di-cis-zeta-carotene => 9,9',15-tri-cis-zeta-carotene
REACT:R-RNO-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Rattus norvegicus)
REACT:R-XTR-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)
REACT:R-HSA-888577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GABA by GAD2 (Homo sapiens)
GO:1901513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-chitin oligosaccharide transmembrane transporter activity
RHEA:17004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amidinoproclavaminate + H2O <=> proclavaminate + urea
GO:0046992	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors
GO:0046992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
GO:0046992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Catalyzing the reaction X-H + Y-H = 'X-Y'"
GO:0046992	skos:prefLabel	"Catalyzing the reaction X-H + Y-H = 'X-Y'"
RHEA:16696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene oxide <=> (Z)-2-methyl-5-isopropylhexa-2,5-dienal
REACT:R-DME-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Drosophila melanogaster)
REACT:R-DDI-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Dictyostelium discoideum)
REACT:R-PFA-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Plasmodium falciparum)
RHEA:58087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(13Z-docosenoyl)-glycerol + H2O <=> (13Z)-docosenoate + glycerol + H(+)
REACT:R-CFA-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Canis familiaris)
GO:0102055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyjasmonate sulfotransferase activity
REACT:R-CFA-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Canis familiaris)
REACT:R-GGA-5654643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)
REACT:R-HSA-8852809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPN, CPB2 cleave C3a, C5a (Homo sapiens)
RHEA:40450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-pristanoyl-CoA <=> (2S)-pristanoyl-CoA
GO:0102897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abietadienal hydroxylase activity
RHEA:23730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + prostaglandin H2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2
REACT:R-HSA-1482907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Homo sapiens)
GO:0052635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-20 gibberellin 2-beta-dioxygenase activity
GO:0052635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-20 gibberellin 2beta-dioxygenase activity
GO:0052635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-20 gibberellin 2-oxidase activity
GO:0052635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-20 gibberellin 2-beta-hydroxylase activity
GO:0052635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-20 gibberellin 2beta-hydroxylase activity
GO:0052635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C(20) gibberellin 2-oxidase activity
GO:0052635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-20 GA 2-oxidase activity
GO:0052635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(C-20 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)
REACT:R-SSC-8984023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Sus scrofa)
REACT:R-HSA-9727188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B binds PPIs (Homo sapiens)
RHEA:54688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alliin = 2-aminoprop-2-enoate + allylsulfenate
RHEA:66628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 = (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2
GO:0047054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	berbamunine synthase activity
GO:0047054	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heme-thiolate
RHEA:60723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hept-2-enal + H2O + NADP(+) <=> (E)-hept-2-enoate + 2 H(+) + NADPH
GO:0044688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
REACT:R-HSA-8936731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
RHEA:67410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol => gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-5229132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 binds APP (Rattus norvegicus)
RHEA:50184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine
REACT:R-HSA-177935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)
REACT:R-HSA-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Homo sapiens)
GO:0048039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquinone binding
GO:0048039	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	coenzyme Q6 binding
GO:0048039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme Q binding
REACT:R-HSA-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Homo sapiens)
RHEA:12038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(imidazol-5-yl)pyruvate + H(+) + NADH => (S)-3-(imidazol-5-yl)lactate + NAD(+)
RHEA:61663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + ATP <=> (2E)-geranyl phosphate + ADP + H(+)
RHEA:63528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + 2 H2O
REACT:R-MMU-429955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR4-NOT complex deadenylates mRNA (Mus musculus)
REACT:R-CFA-9010647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO3.1 binds AKAP5 (Canis familiaris)
REACT:R-MMU-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Mus musculus)
REACT:R-MMU-451942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Within the IL-2R complex JAK3 phosphorylates JAK1 (Mus musculus)
RHEA:44352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide C + H(+) + phosphate
REACT:R-CEL-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)
EC:1.1.1.337	skos:prefLabel	"L-2-hydroxycarboxylate dehydrogenase (NAD(+))"
EC:1.1.1.337	skos:altLabel	"L-2-hydroxyacid dehydrogenase (NAD(+))"
EC:1.1.1.337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-2-hydroxycarboxylate dehydrogenase (NAD(+))"
EC:1.1.1.337	skos:altLabel	"(R)-sulfolactate dehydrogenase"
EC:1.1.1.337	skos:altLabel	"L-sulfolactate dehydrogenase"
REACT:R-HSA-381799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Preproglucagon in intestinal L cells (Homo sapiens)
REACT:R-DDI-3149519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC decyanates CNCbl (Dictyostelium discoideum)
REACT:R-XTR-83677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4 deamination of cytidine (Xenopus tropicalis)
REACT:R-XTR-264865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin A (Xenopus tropicalis)
GO:0043337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cardiolipin synthase (CMP-forming)
GO:0043337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity
GO:0043337	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cardiolipin synthetase
GO:0043337	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cardiolipin synthase
REACT:R-CEL-139970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO3:FAD N-oxidises TMA to TMAO (Caenorhabditis elegans)
GO:0042947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucoside transmembrane transporter activity
RHEA:31639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycinamicin III + S-adenosyl-L-methionine = H(+) + mycinamicin IV + S-adenosyl-L-homocysteine
RHEA:31639	skos:prefLabel	"mycinamicin III 3''-O-methyltransferase"
RHEA:31639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycinamicin III 3''-O-methyltransferase"
RHEA:35112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-L-idonate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH
REACT:R-DRE-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Danio rerio)
REACT:R-RNO-9661723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)
RHEA:52350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate
RHEA:29746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine(in) <=> 2-phenylethylamine(out)
REACT:R-HSA-9603983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeX to form LeY (Homo sapiens)
REACT:R-BTA-2574840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA facilitates AURKA autophosphorylation (Bos taurus)
REACT:R-XTR-2168046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XII degradation by MMP12 (Xenopus tropicalis)
RHEA:68258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine(out) + Na(+)(out) => L-cystine(in) + Na(+)(in)
RHEA:27571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glycero-alpha-D-manno-heptose 7-phosphate => ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)
RHEA:70846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-methionine(out) + Na(+)(out) <=> L-arginine(out) + L-methionine(in) + Na(+)(in)
REACT:R-MMU-5423637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR dimers reduce AFBDHO to AFBDOH (Mus musculus)
RHEA:33545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol + H(+) + hexadecanoate => ergosteryl palmitate + H2O
RHEA:50967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(8) in tRNA + H(+) + H2O <=> NH4(+) + uridine(8) in tRNA
GO:0035500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD homology 2 domain binding
GO:0035500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MH2 domain binding
REACT:R-CFA-8849345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Canis familiaris)
REACT:R-RNO-8871266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD3 (Rattus norvegicus)
REACT:R-XTR-8864036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates PDGFRB at Y1021 (Xenopus tropicalis)
RHEA:22329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) => diphosphate + thiamine phosphate
REACT:R-DRE-1234167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of HIF:CBP:p300 complex at promoters (Danio rerio)
GO:0005260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	channel-conductance-controlling ATPase activity
GO:0005260	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cystic fibrosis transmembrane conductance regulator
GO:0005260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellularly ATP-gated chloride channel activity
GO:0005260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR
REACT:R-MMU-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Mus musculus)
REACT:R-XTR-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Xenopus tropicalis)
RHEA:17027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-xylulose + NADPH => NADP(+) + xylitol
REACT:R-SSC-8866327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL translocates from SER lumen to extracellular region (Sus scrofa)
RHEA:35004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fucose(in) => L-fucose(out)
RHEA:53666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + pyridinestrone carboxylate => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+)
RHEA:20036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopenicillin N <=> penicillin N
REACT:R-XTR-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Xenopus tropicalis)
RHEA:50917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + ATP + H(+) + NADPH => AMP + an aldehyde + diphosphate + NADP(+)
RHEA:56723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]
GO:0047893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity
GO:0047893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG:flavonoid-3-O-glucosyltransferase activity
GO:0047893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose flavonol 3-O-glucosyltransferase activity
GO:0047893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:flavonol 3-O-glucosyltransferase activity
GO:0047893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol 3-O-glucosyltransferase activity
GO:0047893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:flavonol 3-O-D-glucosyltransferase activity
GO:0047893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:flavonol 3-O-D-glucosyltransferase activity
GO:0047893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTI
RHEA:41231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:52466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate
REACT:R-RNO-5694417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Rattus norvegicus)
REACT:R-MMU-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Mus musculus)
RHEA:68369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose => 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP
GO:0044013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2B histone acetylase activity
GO:0044013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2B histone lysine N-acetyltransferase activity
GO:0044013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2B acetyltransferase activity
GO:0044013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2B histone acetyltransferase activity
RHEA:50311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-350440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FT binds to DS in an adjacent cell (Drosophila melanogaster)
REACT:R-MMU-5649873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)
REACT:R-CEL-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Caenorhabditis elegans)
RHEA:39603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA = (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O
REACT:R-HSA-5625848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)
RHEA:65686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine
RHEA:28982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + nitrite(in) <=> H(+)(in) + nitrite(out)
REACT:R-MMU-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Mus musculus)
REACT:R-DRE-5693549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Danio rerio)
REACT:R-CFA-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Canis familiaris)
REACT:R-DRE-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Danio rerio)
RHEA:46598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-N-hydroxyrifampicin + H2O + NADP(+) => NADPH + O2 + rifampicin
RHEA:48575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dichlorocatechol + O2 <=> (2E,4E)-2,4-dichloromuconate + 2 H(+)
REACT:R-HSA-159425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
RHEA:39254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (11Z)-eicosenoyl-CoA + NADP(+)
RHEA:10236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-coumarate O-beta-glucosyltransferase"
RHEA:10236	skos:prefLabel	"2-coumarate O-beta-glucosyltransferase"
RHEA:10236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2-coumarate + UDP-alpha-D-glucose = H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP
RHEA:40112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H2O => butanoate + CoA + H(+)
RHEA:44983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + butanoyl-CoA <=> CoA + O-butanoyl-(R)-carnitine
RHEA:15045	skos:altLabel	"lipoamide dehydrogenase (NADH)"
RHEA:15045	skos:altLabel	"LDP-Val"
RHEA:15045	skos:altLabel	"dihydrolipoic dehydrogenase"
RHEA:15045	skos:altLabel	"dihydrothioctic dehydrogenase"
RHEA:15045	skos:altLabel	"lipoamide reductase"
RHEA:15045	skos:altLabel	"diaphorase"
RHEA:15045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH
RHEA:15045	skos:altLabel	"lipoate dehydrogenase"
RHEA:15045	skos:altLabel	"LDP-Glc"
RHEA:15045	skos:altLabel	"L-protein"
RHEA:15045	skos:altLabel	"dehydrolipoate dehydrogenase"
RHEA:15045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoamide + NAD(+) = (R)-lipoamide + H(+) + NADH
RHEA:15045	skos:altLabel	"lipoyl dehydrogenase"
RHEA:15045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrolipoyl dehydrogenase"
RHEA:15045	skos:altLabel	"E3 component of alpha-ketoacid dehydrogenase complexes"
RHEA:15045	skos:altLabel	"glycine-cleavage system L-protein"
RHEA:15045	skos:prefLabel	"dihydrolipoyl dehydrogenase"
RHEA:15045	skos:altLabel	"lipoamide oxidoreductase (NADH)"
RHEA:15045	skos:altLabel	"lipoic acid dehydrogenase"
RHEA:15045	skos:altLabel	"dihydrolipoamide dehydrogenase"
RHEA:15045	skos:altLabel	"lipoamide reductase (NADH)"
RHEA:40231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-9009282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates RUNX2 (Sus scrofa)
RHEA:55724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)
REACT:R-CFA-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Canis familiaris)
REACT:R-PFA-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Plasmodium falciparum)
REACT:R-CFA-1168633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB translocates from the cytosol to the nucleus (Canis familiaris)
RHEA:35991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-CEL-8848930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 translocates to the nucleus (Caenorhabditis elegans)
RHEA:22023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + molybdate(out) <=> ADP + H(+) + molybdate(in) + phosphate
REACT:R-MMU-9710263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GZMB cleaves GSDME (Mus musculus)
REACT:R-BTA-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Bos taurus)
REACT:R-MMU-6783524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM,LIF,CTF1 receptor complex binds gp130 (Mus musculus)
RHEA:10007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl isothiocyanate <=> benzyl thiocyanate
REACT:R-DME-2162225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)
REACT:R-SSC-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Sus scrofa)
RHEA:18522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	licodione + S-adenosyl-L-methionine => 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-6799179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Canis familiaris)
RHEA:40665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + H2O => L-serine
RHEA:40525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + fumarate => a quinone + succinate
REACT:R-MMU-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Mus musculus)
REACT:R-RNO-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Rattus norvegicus)
REACT:R-CEL-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Caenorhabditis elegans)
REACT:R-DRE-5654165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR1 (Danio rerio)
REACT:R-RNO-4420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 disassociates from VEGFR2 and translocate to PM (Rattus norvegicus)
RHEA:43731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]
RHEA:45531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
RHEA:11308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphate
RHEA:11308	skos:prefLabel	"acetyl-CoA carboxylase"
RHEA:11308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetyl-CoA carboxylase"
REACT:R-CEL-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Caenorhabditis elegans)
REACT:R-GGA-5685838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex binds D-loop structures (Gallus gallus)
REACT:R-SSC-193054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cholesterol to 22beta-hydroxycholesterol (Sus scrofa)
RHEA:41127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine
RHEA:57742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH => a 2,3-saturated meromycolyl-[ACP] + NAD(+)
REACT:R-HSA-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Homo sapiens)
REACT:R-CEL-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Caenorhabditis elegans)
GO:0002172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity IgM receptor activity
GO:0002172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity IgM receptor activity
RHEA:62042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-octanoylsphing-4-enine + phosphate => H2O + N-(octanoyl)-sphing-4-enine-1-phosphate
REACT:R-CEL-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Caenorhabditis elegans)
REACT:R-DME-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)
REACT:R-RNO-71050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of the FASL:FAS receptor complex (Rattus norvegicus)
RHEA:62114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + iminosuccinate => (3S)-3-hydroxy-D-aspartate
REACT:R-CEL-8944230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Caenorhabditis elegans)
REACT:R-HSA-9796387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Homo sapiens)
GO:0034325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-decanoyltransferase activity
RHEA:60486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic CMP-UMP + 2 diphosphate => CTP + UTP
RHEA:27931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4-phosphopantoate + ATP + beta-alanine => (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)
RHEA:66359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) <=> (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH
RHEA:34895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + selenite(out) = ADP + H(+) + phosphate + selenite(in)
GO:0003726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	double-stranded RNA specific editase activity
GO:0003726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded RNA adenosine deaminase activity
EC:2.7.7.48	skos:altLabel	"RNA nucleotidyltransferase (RNA-directed)"
EC:2.7.7.48	skos:prefLabel	"RNA-directed RNA polymerase"
EC:2.7.7.48	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RNA-directed RNA polymerase"
REACT:R-SSC-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Sus scrofa)
REACT:R-DRE-71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Danio rerio)
REACT:R-SSC-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Sus scrofa)
RHEA:22789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylsulfonioacetate + L-homocysteine => (methylsulfanyl)acetate + H(+) + L-methionine
REACT:R-HSA-9666426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRKII:DOCK180:ELMO binds FCGR3A (Homo sapiens)
GO:0102417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin-7-O-glucoside 1,6-glucosyltransferase activity
RHEA:47226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-5218818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Gallus gallus)
REACT:R-MMU-5654562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Mus musculus)
REACT:R-HSA-75886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Homo sapiens)
REACT:R-GGA-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Gallus gallus)
RHEA:67213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 => (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2
REACT:R-SSC-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Sus scrofa)
RHEA:38205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:21693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glycerol + H2O => CMP + 2 H(+) + sn-glycerol 3-phosphate
REACT:R-BTA-374248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR3 binds ligands CXCL9 to 11 (Bos taurus)
REACT:R-DME-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Drosophila melanogaster)
RHEA:61990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA + S-adenosyl-L-methionine
REACT:R-XTR-6804942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 homodimers auto-ubiquitinate (Xenopus tropicalis)
REACT:R-MMU-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Mus musculus)
REACT:R-RNO-2213246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of CLIP from MHC II (Rattus norvegicus)
RHEA:66781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O => N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate
REACT:R-RNO-9007447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 forms the PRC1L4 complex (Rattus norvegicus)
RHEA:28240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin => calycosin + O2 + reduced [NADPH--hemoprotein reductase]
GO:0051407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerone phosphate:inorganic phosphate antiporter activity
GO:0051407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone-phosphate:inorganic phosphate antiporter activity
REACT:R-CFA-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Canis familiaris)
RHEA:59305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + firefly L-luciferin => adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)
REACT:R-DME-6814885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)
REACT:R-SSC-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Sus scrofa)
REACT:R-XTR-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Xenopus tropicalis)
RHEA:23004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP
REACT:R-HSA-8948775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKRN1 polyubiquitinates PTEN (Homo sapiens)
RHEA:67346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside) => kaempferol 7-O-beta-D-glucoside + malonyl-CoA
REACT:R-DRE-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Danio rerio)
RHEA:54165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
GO:0034277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) activity
GO:0034277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene synthase activity
RHEA:55033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-methylornithine lipid + S-adenosyl-L-methionine => an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-74711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRS (Bos taurus)
RHEA:30508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinone-8 + H(+) + NADH => 2-demethylmenaquinol-8 + NAD(+)
REACT:R-PFA-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Plasmodium falciparum)
REACT:R-SPO-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Schizosaccharomyces pombe)
RHEA:63619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin + UDP-alpha-D-glucuronate <=> H(+) + prunetin-C(8)-beta-D-glucuronide + UDP
REACT:R-DRE-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Danio rerio)
REACT:R-XTR-933533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of p-IRF7 (Xenopus tropicalis)
RHEA:36842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:11545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine
REACT:R-CFA-6810472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT13 hydrolyses AP6A to AP4 and ADP (Canis familiaris)
RHEA:63397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + Fe(II)-heme i + H2O => AH2 + Fe(II)-hydroxyheme i
RHEA:55314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate
RHEA:12285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methylglutarate + succinyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + succinate
REACT:R-CFA-200143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates AKT1S1 (PRAS40) (Canis familiaris)
RHEA:54693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate
RHEA:37333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + L-methionine => H2O + L-methionyl-L-alanine
REACT:R-SSC-451311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca-permeable Kainate receptors (Sus scrofa)
RHEA:31841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose
RHEA:67167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + FADH2 + melleolide F + O2 <=> 6'-bromomelleolide F + FAD + 2 H2O
GO:0016215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O
GO:0016215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA desaturase activity
GO:0016215	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CoA desaturase activity
GO:0036468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa decarboxylase activity
GO:0036468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDC activity
GO:0036468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DOPA decarboxylase activity
GO:0036468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-dihydroxyl-L-phenylalanine decarboxylase activity
GO:0036468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-dopa = CO2 + dopamine
REACT:R-DME-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
REACT:R-RNO-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
REACT:R-MMU-202453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Mus musculus)
REACT:R-BTA-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Bos taurus)
REACT:R-SSC-174657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Sus scrofa)
RHEA:46840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:32089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate
RHEA:41911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-[ACP] <=> (2E)-hexadecenoyl-[ACP] + H2O
RHEA:16128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-fructose <=> ADP + D-fructose 6-phosphate + H(+)
RHEA:32153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12E)-9alpha-labda-8(17),12,14-triene + diphosphate => 9alpha-copalyl diphosphate
REACT:R-GGA-204863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang2 (Gallus gallus)
REACT:R-SSC-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Sus scrofa)
RHEA:40569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dTDP-beta-L-evernitrose + H2O => AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2
RHEA:25712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-392530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S400-Cot phosphorylates NIK (Danio rerio)
RHEA:21437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[translation elongation factor 2] + ATP => [translation elongation factor 2]-phosphate + ADP + H(+)
RHEA:39500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O
RHEA:41083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-HSA-5654569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS2 (Homo sapiens)
EC:1.17.8.-	skos:prefLabel	"With a flavin as acceptor"
EC:1.17.8.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a flavin as acceptor"
REACT:R-BTA-1981157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of collagen propeptide hydroxylysines (Bos taurus)
RHEA:14431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [oligopeptide](out) + ADP + H(+) + phosphate => a [oligopeptide](in) + ATP + H2O
RHEA:62342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)
RHEA:39329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA
RHEA:30837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
RHEA:24499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-deacetylvindoline + acetyl-CoA <=> CoA + vindoline
REACT:R-DME-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Drosophila melanogaster)
RHEA:13727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => acetyl-CoA + alpha-D-glucosamine 1-phosphate
RHEA:34462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycopalyl diphosphate + H2O <=> diphosphate + sclareol
REACT:R-HSA-6789072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP1 binds bacterial peptidoglycan (Homo sapiens)
REACT:R-XTR-3781024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Xenopus tropicalis)
REACT:R-BTA-6791235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds AURKA (Bos taurus)
REACT:R-SSC-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Sus scrofa)
RHEA:64151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)
REACT:R-CEL-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Caenorhabditis elegans)
RHEA:49916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)
REACT:R-RNO-8933452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE dimer binds phosphorylated DENND1 proteins (Rattus norvegicus)
REACT:R-BTA-140686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Bos taurus)
REACT:R-HSA-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Homo sapiens)
REACT:R-SSC-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Sus scrofa)
RHEA:65803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O <=> a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine
RHEA:54998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate
GO:0005112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N binding
GO:0005112	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Notch ligand
GO:0005112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Notch receptor binding
GO:0005112	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	N ligand
GO:0005112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Notch binding
REACT:R-XTR-975040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAB-ZNF / KAP Interaction (Xenopus tropicalis)
GO:0034920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrene dioxygenase activity
REACT:R-BTA-70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Bos taurus)
EC:3.1.5.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Triphosphoric monoester hydrolases"
EC:3.1.5.-	skos:prefLabel	"Triphosphoric monoester hydrolases"
REACT:R-HSA-5602892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GCLC does not ligate L-Glu to L-Cys (Homo sapiens)
RHEA:22782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2
REACT:R-BTA-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)
REACT:R-RNO-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Rattus norvegicus)
RHEA:50116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + taurine = CoA + H(+) + N-eicosanoyl-taurine
REACT:R-MMU-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Mus musculus)
REACT:R-HSA-2197697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)
RHEA:14673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a polar amino acid(out) + ATP + H2O = a polar amino acid(in) + ADP + H(+) + phosphate
REACT:R-XTR-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Xenopus tropicalis)
REACT:R-RNO-3858482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is recruited to the receptor (Rattus norvegicus)
RHEA:21622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + 2 H(+) + NADH => FMNH2 + NAD(+)
REACT:R-MMU-8980228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Mus musculus)
REACT:R-DME-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Drosophila melanogaster)
REACT:R-MMU-5693148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDK phosphorylates BCKDH (Mus musculus)
RHEA:59123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) <=> 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2
REACT:R-DDI-8932276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Dictyostelium discoideum)
REACT:R-DME-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Drosophila melanogaster)
RHEA:33877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + cholesterol + H(+) => cholesteryl (9Z-octadecenoate) + H2O
REACT:R-DME-170087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)
RHEA:63391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + Fe(II)-heme o + H2O <=> 2 AH2 + Fe(II)-heme a
REACT:R-CFA-8964614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Canis familiaris)
REACT:R-MMU-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Mus musculus)
RHEA:19236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-hexadecanoyl-L-cysteinyl-[protein] <=> H(+) + hexadecanoate + L-cysteinyl-[protein]
RHEA:39886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-alpha-D-allose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH
REACT:R-BTA-2029270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLCgamma to membrane (Bos taurus)
RHEA:14638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a thiol => adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate
RHEA:39915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycerol + phosphate
EC:1.1.1.203	skos:altLabel	"uronic acid dehydrogenase"
EC:1.1.1.203	skos:prefLabel	"uronate dehydrogenase"
EC:1.1.1.203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uronate dehydrogenase"
RHEA:33854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) <=> GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine
REACT:R-DME-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Drosophila melanogaster)
RHEA:15474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose => flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP
RHEA:67235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) <=> (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH
REACT:R-MMU-2203480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC11 binds ligands (Mus musculus)
RHEA:44043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
RHEA:10443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone + H2O <=> D-gluconate + H(+)
RHEA:59461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + NADP(+) => H(+) + hexadecanal + NADPH
REACT:R-CEL-2187401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 dephosphorylates SMAD2/3 (Caenorhabditis elegans)
RHEA:28432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allulose 6-phosphate => D-allose 6-phosphate
RHEA:42022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone => 11-dehydrocorticosterone + NAD(+)
REACT:R-XTR-6809254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR8 binds MTMR9 (Xenopus tropicalis)
REACT:R-BTA-8869633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NR to yield NMN (Bos taurus)
REACT:R-CFA-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Canis familiaris)
RHEA:33360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CEL-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Caenorhabditis elegans)
REACT:R-SSC-9614273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGRG heterodimer translocates to plasma membrane (Sus scrofa)
RHEA:61267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanine + O2 <=> H2O2 + NH4(+) + pyruvate
REACT:R-SSC-2574845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA binds centrosome-associated AURKA (Sus scrofa)
REACT:R-DDI-165692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of 4E-BP1 by activated mTORC1 (Dictyostelium discoideum)
RHEA:53848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + taurocholate = 7-oxo-taurodeoxycholate + H(+) + NADH
RHEA:39107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
REACT:R-XTR-6804741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 forms homo- or heterodimers (Xenopus tropicalis)
REACT:R-DRE-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Danio rerio)
RHEA:47223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1592371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP3 (Rattus norvegicus)
REACT:R-BTA-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Bos taurus)
RHEA:28900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + H(+)(in) => glycine(out) + H(+)(out)
REACT:R-CFA-374298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid receptors bind opioid peptides (Canis familiaris)
RHEA:59818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sterol ester + CoA => a long-chain fatty acyl-CoA + a sterol
REACT:R-XTR-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Xenopus tropicalis)
RHEA:56295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5251557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of AMER1 gene (Homo sapiens)
REACT:R-CEL-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Caenorhabditis elegans)
REACT:R-XTR-8879117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT2 transfers GlcNAc to Man-DAG1 (Xenopus tropicalis)
RHEA:43897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:27879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-UMP + H2O => 3'-UMP + H(+)
GO:0004971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPA glutamate receptor activity
GO:0004971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0004971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPA receptor activity
REACT:R-RNO-1254251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds YAP1 (Rattus norvegicus)
REACT:R-HSA-3132753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pancreatic proteases degrade TCN1:RCbl (Homo sapiens)
RHEA:68673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-9028255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises EPA to PGH3 (Canis familiaris)
REACT:R-CEL-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Caenorhabditis elegans)
REACT:R-RNO-2730868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK7 by MEKK1 (Rattus norvegicus)
REACT:R-SSC-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Sus scrofa)
REACT:R-XTR-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Xenopus tropicalis)
REACT:R-HSA-5693071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACE1 translocates from ER lumen to Golgi apparatus (Homo sapiens)
RHEA:61462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine
REACT:R-BTA-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Bos taurus)
RHEA:68848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = diphosphate + gamma-cadinene
REACT:R-SSC-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Sus scrofa)
REACT:R-HSA-8852013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL8 binds resting T cell surface (Homo sapiens)
REACT:R-DME-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Drosophila melanogaster)
REACT:R-XTR-9734475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds fibrates (Xenopus tropicalis)
REACT:R-MMU-5696457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDH2 dehydrogenates 3HBA (Mus musculus)
RHEA:51101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
RHEA:69686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein 7-O-beta-D-glucoside + H2O <=> beta-D-glucose + daidzein + H(+)
REACT:R-DDI-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Dictyostelium discoideum)
RHEA:59105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate => a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)
RHEA:48821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
REACT:R-RNO-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Rattus norvegicus)
RHEA:49439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + deoxycholoyl-CoA <=> choloyl-CoA + deoxycholate
REACT:R-CEL-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Caenorhabditis elegans)
REACT:R-SCE-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Saccharomyces cerevisiae)
RHEA:39899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-deoxyloganetin glucosyltransferase"
RHEA:39899	skos:prefLabel	"7-deoxyloganetin glucosyltransferase"
RHEA:39899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetin + UDP-alpha-D-glucose = 7-deoxyloganin + H(+) + UDP
RHEA:39899	skos:altLabel	"UGT85A24"
REACT:R-HSA-209903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline is converted to adrenaline (Homo sapiens)
REACT:R-RNO-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Rattus norvegicus)
REACT:R-HSA-2022061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan sulfate can be further sulfated on position 2 of iduronate (Homo sapiens)
REACT:R-CEL-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Caenorhabditis elegans)
RHEA:10107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A20 + O2 <=> CO2 + gibberellin A1 + succinate
RHEA:37707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
RHEA:53923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]
RHEA:63151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-taurine <=> (9Z)-octadecenoate + taurine
REACT:R-XTR-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Xenopus tropicalis)
RHEA:10846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + pyridoxal => oxaloacetate + pyridoxamine
REACT:R-RNO-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Rattus norvegicus)
RHEA:41867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-[ACP] + H(+) + NADPH <=> decanoyl-[ACP] + NADP(+)
RHEA:41117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O
RHEA:42090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Mus musculus)
REACT:R-BTA-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Bos taurus)
RHEA:52268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(aminomethyl)indole + S-adenosyl-L-methionine = (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine
RHEA:41103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)
RHEA:48518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O
REACT:R-HSA-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Homo sapiens)
REACT:R-CFA-201821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Canis familiaris)
REACT:R-HSA-6805755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)
GO:0048256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flap endonuclease activity
REACT:R-HSA-9698927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the HCMV Genome DNA Replication Complex (Homo sapiens)
REACT:R-RNO-1676174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Rattus norvegicus)
RHEA:34520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP
REACT:R-SCE-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Saccharomyces cerevisiae)
RHEA:69139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 O2 + spermine <=> 2 H2O2 + 2 NH4(+) + spermine dialdehyde
REACT:R-MMU-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Mus musculus)
REACT:R-DRE-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Danio rerio)
RHEA:44093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + nonadecanoate => AMP + diphosphate + nonadecanoyl-CoA
REACT:R-DRE-1980125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH binds DTX (Danio rerio)
REACT:R-SSC-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Sus scrofa)
REACT:R-DME-209331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 'scaffold complex' (Drosophila melanogaster)
REACT:R-HSA-2426148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C binds the FASN promoter (Homo sapiens)
REACT:R-CFA-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Canis familiaris)
REACT:R-CEL-2187309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer binds SP1 (Caenorhabditis elegans)
RHEA:44245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:58843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + O2 = D-sorbopyranose + H2O2
REACT:R-RNO-2514867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Rattus norvegicus)
REACT:R-SSC-1564112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VI degradation by MMP2,9,11 (Sus scrofa)
REACT:R-HSA-6800396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates PIDD1 expression (Homo sapiens)
RHEA:33839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) = 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate
RHEA:33839	skos:prefLabel	"7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase"
RHEA:33839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase"
REACT:R-HSA-3318563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MTRR does not convert cob(II)alamin to MeCbl (Homo sapiens)
REACT:R-RNO-9710354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds cardiolipin (Rattus norvegicus)
REACT:R-HSA-5607728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
REACT:R-SSC-8854303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D11 binds RAB6 (Sus scrofa)
RHEA:41102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-GGA-74743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-Y427-SHC1 from insulin receptor (Gallus gallus)
RHEA:43222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine
RHEA:31110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + O2 <=> (2-hydroxyphenyl)acetate + CO2
REACT:R-HSA-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Homo sapiens)
REACT:R-HSA-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Homo sapiens)
REACT:R-RNO-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Rattus norvegicus)
RHEA:22058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanal + NADH => hexadecan-1-ol + NAD(+)
REACT:R-DRE-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Danio rerio)
RHEA:16613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an arylamine = an N-acetylarylamine + CoA
RHEA:16613	skos:prefLabel	"arylamine N-acetyltransferase"
RHEA:16613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arylamine N-acetyltransferase"
RHEA:16613	skos:altLabel	"arylamine acetylase"
REACT:R-BTA-1471338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 1, 4A and 103 bind CCR6 (Bos taurus)
GO:0019840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoprenoid binding
GO:0050363	skos:altLabel	"L-tryptophan dehydrogenase"
GO:0050363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan:NAD(P)+ oxidoreductase (deaminating)
GO:0050363	skos:prefLabel	"tryptophan dehydrogenase"
GO:0050363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TrpDH activity
GO:0050363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)+-L-tryptophan dehydrogenase activity
GO:0050363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan dehydrogenase activity
GO:0050363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-Trp-dehydrogenase activity
GO:0050363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan dehydrogenase activity
GO:0050363	skos:altLabel	"TrpDH"
GO:0050363	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDH
GO:0050363	skos:altLabel	"L-Trp-dehydrogenase"
GO:0050363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan dehydrogenase"
REACT:R-HSA-6802170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates PLK3 expression (Homo sapiens)
REACT:R-SSC-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Sus scrofa)
RHEA:45772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-1,4-mannooligosaccharide phosphorylase"
RHEA:45772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannosyl](n) + phosphate = [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate
RHEA:45772	skos:prefLabel	"beta-1,4-mannooligosaccharide phosphorylase"
EC:3.6.5.1	skos:prefLabel	"heterotrimeric G-protein GTPase"
EC:3.6.5.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heterotrimeric G-protein GTPase"
RHEA:12040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(imidazol-5-yl)lactate + NADP(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADPH
REACT:R-HSA-3234094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TFAP2C with SUMO1 (Homo sapiens)
GO:0009924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanal decarbonylase activity
GO:0009924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanal alkane-lyase activity
REACT:R-DME-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)
RHEA:20262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7-trioxododecanoyl-CoA => CO2 + CoA + olivetol
RHEA:66547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]
REACT:R-GGA-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Gallus gallus)
RHEA:23594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + H(+) + NADPH => glycerol + NADP(+)
RHEA:11243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine diphosphate <=> ADP + thiamine triphosphate
REACT:R-XTR-1250220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of ERBB4 (Xenopus tropicalis)
REACT:R-DRE-350318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at TNLD (429) (Danio rerio)
RHEA:44390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA
REACT:R-SSC-8951498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Sus scrofa)
RHEA:35680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + L-serine => 3-oxotetradecasphinganine + CO2 + CoA
REACT:R-DRE-211919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F8 19-hydroxylates PGH2 (Danio rerio)
REACT:R-BTA-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Bos taurus)
REACT:R-MMU-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Mus musculus)
GO:0047515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity
GO:0047515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-beta-oligoglucan phosphorylase activity
GO:0047515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,3-oligoglucan phosphorylase activity
GO:0047515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity
REACT:R-DME-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Drosophila melanogaster)
REACT:R-CFA-4088024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Canis familiaris)
RHEA:57377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Canis familiaris)
RHEA:66945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C
RHEA:45682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in)
REACT:R-CFA-114261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-7 by the apoptosome (Canis familiaris)
RHEA:56549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
REACT:R-SCE-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Saccharomyces cerevisiae)
REACT:R-HSA-9750226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 binds IKBKB and CHUK (Homo sapiens)
RHEA:40832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
REACT:R-GGA-5654646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Gallus gallus)
REACT:R-SSC-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Sus scrofa)
REACT:R-CFA-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Canis familiaris)
GO:0001604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urotensin II receptor activity
REACT:R-DRE-199935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates CREB (Danio rerio)
RHEA:66194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate => ATP + bilirubin-bisglucuronoside(in) + H2O
REACT:R-HSA-9681840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTC synthesizes SARS-CoV-1 plus strand genomic RNA (Homo sapiens)
REACT:R-SSC-8939203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Sus scrofa)
REACT:R-RNO-5228521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Rattus norvegicus)
REACT:R-HSA-9692241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SRY in testis differentiation (Homo sapiens)
REACT:R-SSC-3149494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC:cob(II)alamin binds MMADHC (Sus scrofa)
GO:0140760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone demethylase activity (H3-K56 specific)
GO:0140760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-tri/dimethyl-lysine-56 demethylase activity
GO:0140760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H3K56me3 demethylase activity
GO:0140760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H3K56me2 demethylase activity
GO:0140760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K56me2/H3K56me3 demethylase activity
RHEA:19048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O + pyruvate <=> (3R)-citramalate + CoA + H(+)
RHEA:29558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + 2 H(+) + UMP
RHEA:69008	skos:prefLabel	"L-aspartate N-monooxygenase (nitrosuccinate-forming)"
RHEA:69008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-aspartate N-monooxygenase (nitrosuccinate-forming)"
RHEA:69008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-aspartate + 3 NADPH + 3 O2 = 2-nitrobutanedioate + 4 H2O + 3 NADP(+)
RHEA:18277	skos:prefLabel	"thiol S-methyltransferase"
RHEA:18277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiol S-methyltransferase"
RHEA:18277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thiol + S-adenosyl-L-methionine = a methyl thioether + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-1793182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Canis familiaris)
RHEA:52244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 Mn(2+) + O2 = 2 H2O + 4 Mn(3+)
REACT:R-SCE-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Saccharomyces cerevisiae)
REACT:R-CFA-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Canis familiaris)
RHEA:56374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+) => 3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2
REACT:R-CEL-1981157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of collagen propeptide hydroxylysines (Caenorhabditis elegans)
REACT:R-DDI-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Dictyostelium discoideum)
REACT:R-RNO-917891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Rattus norvegicus)
REACT:R-MMU-5685985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Mus musculus)
REACT:R-HSA-5682690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 dissociates from ATG12:ATG5 (Homo sapiens)
REACT:R-HSA-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Homo sapiens)
GO:0034211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent protein kinase activity
REACT:R-CEL-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)
RHEA:54455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in tRNA + NAD(+) <=> a uridine in tRNA + H(+) + NADH
RHEA:38685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + sphing-4-enine(out) => ATP + H2O + sphing-4-enine(in)
GO:0004001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine kinase activity
GO:0004001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine kinase (phosphorylating)
GO:0004001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5-phosphotransferase activity
GO:0004001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:adenosine 5'-phosphotransferase activity
REACT:R-DME-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
RHEA:46027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + tetradecanoate <=> (3R)-hydroxytetradecanoate + H2O
RHEA:44140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate = acetyl-CoA + CO2 + reduced [flavodoxin]
RHEA:70820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoarginine(in) + L-ornithine(out) => L-homoarginine(out) + L-ornithine(in)
RHEA:59130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate => (S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP
RHEA:58000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg3 + H(+) + UDP
RHEA:32116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + DIBOA beta-D-glucoside + O2 => CO2 + succinate + TRIBOA beta-D-glucoside
RHEA:64708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + NADP(+) = butanal + H(+) + NADPH
REACT:R-SPO-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Schizosaccharomyces pombe)
REACT:R-CEL-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Caenorhabditis elegans)
RHEA:41290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetradecanoylsphing-4-enine <=> sphing-4-enine + tetradecanoate
REACT:R-DME-2187325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)
RHEA:14658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate
REACT:R-DRE-9626928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP binds FOXO1 (Danio rerio)
RHEA:43153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(58) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine
RHEA:66454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+)
REACT:R-RNO-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)
REACT:R-GGA-1227694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dsRNA binds to MDA5 (Gallus gallus)
REACT:R-MMU-9025957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Mus musculus)
REACT:R-MMU-9024983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Mus musculus)
RHEA:34973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(3+)(out) => Fe(3+)(in)
REACT:R-BTA-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Bos taurus)
REACT:R-CFA-5658424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Canis familiaris)
RHEA:64941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGDP + H2O => dGMP + H(+) + phosphate
REACT:R-MMU-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Mus musculus)
GO:0102411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin-3,4'-O-glucosyltransferase activity
REACT:R-DDI-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Dictyostelium discoideum)
RHEA:14778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + H2O => IMP + NH4(+)
REACT:R-CEL-75872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Caenorhabditis elegans)
REACT:R-CFA-6797974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRTMs bind NRXNs (Canis familiaris)
REACT:R-RNO-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Rattus norvegicus)
REACT:R-MMU-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Mus musculus)
REACT:R-BTA-114263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization  of BAK at the mitochondrial membrane (Bos taurus)
RHEA:69377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydodecanoate + O2 => 2-oxododecanoate + H2O2
REACT:R-RNO-8952128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TP53 (Rattus norvegicus)
RHEA:16439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a halide anion + an S-substituted glutathione + H(+) => glutathione + RX
REACT:R-XTR-2160492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4I1:FAD oxidises L-Phe to kPPV (Xenopus tropicalis)
REACT:R-SPO-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-CEL-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Caenorhabditis elegans)
REACT:R-CFA-201639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of GAS2 (Canis familiaris)
REACT:R-DDI-163756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of fatty acid synthase (FAS) dimer (Dictyostelium discoideum)
REACT:R-MMU-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Mus musculus)
REACT:R-DRE-77615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR2) (Danio rerio)
REACT:R-HSA-210292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and TREM1 (Homo sapiens)
REACT:R-DRE-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Danio rerio)
REACT:R-SSC-8855825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTRA1 hydrolyzes ACAN (Aggrecan) (Sus scrofa)
RHEA:70023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(in) + Na(+)(in) = 4-hydroxy-L-proline(out) + Na(+)(out)
RHEA:16737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)
RHEA:16737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"toluene dioxygenase"
RHEA:16737	skos:altLabel	"toluene 1,2-dioxygenase"
RHEA:16737	skos:prefLabel	"toluene dioxygenase"
REACT:R-DRE-5649705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)
REACT:R-DRE-446692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 binds to MYD88 within the IL1R complex (Danio rerio)
REACT:R-CEL-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Caenorhabditis elegans)
REACT:R-SSC-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Sus scrofa)
RHEA:72077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + ophthalmate + phosphate => ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine
REACT:R-GGA-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Gallus gallus)
RHEA:23291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + H(+) + NADH
REACT:R-SPO-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Schizosaccharomyces pombe)
RHEA:69338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-alkanethial oxide => (E)-alk-1-en-1-SO-peroxol
REACT:R-DME-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Drosophila melanogaster)
REACT:R-HSA-9016861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCRA gene expression is stimulated by NOTCH3 and inhibited by IK1 (Homo sapiens)
RHEA:66829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate
RHEA:65495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine
REACT:R-DRE-5678261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Danio rerio)
REACT:R-DME-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Drosophila melanogaster)
REACT:R-SPO-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Schizosaccharomyces pombe)
REACT:R-SSC-9710353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds cardiolipin (Sus scrofa)
REACT:R-RNO-3002811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates PLK1 (Rattus norvegicus)
RHEA:28992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminate(in) => N-acetylneuraminate(out)
EC:2.7.7.28	skos:altLabel	"GDP hexose pyrophosphorylase"
EC:2.7.7.28	skos:prefLabel	"nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase"
EC:2.7.7.28	skos:altLabel	"hexose 1-phosphate nucleotidyltransferase"
EC:2.7.7.28	skos:altLabel	"GTP:alpha-D-hexose-1-phosphate guanylyltransferase"
EC:2.7.7.28	skos:altLabel	"nucleoside diphosphohexose pyrophosphorylase"
EC:2.7.7.28	skos:altLabel	"NDP-hexose pyrophosphorylase"
EC:2.7.7.28	skos:altLabel	"nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase"
EC:2.7.7.28	skos:altLabel	"NTP:hexose-1-phosphate nucleotidyltransferase"
EC:2.7.7.28	skos:altLabel	"hexose nucleotidylating enzyme"
EC:2.7.7.28	skos:altLabel	"NDP-hexose diphosphorylase"
EC:2.7.7.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase"
EC:2.7.7.28	skos:altLabel	"guanosine diphosphohexose pyrophosphorylase"
EC:2.7.7.28	skos:altLabel	"hexose-1-phosphate guanylyltransferase"
RHEA:56367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-dihydrocarminomycin + H(+) + NADPH + O2 <=> carminomycin + 2 H2O + NADP(+)
REACT:R-SSC-140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Sus scrofa)
RHEA:55607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base
GO:0051075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity
GO:0051075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity
REACT:R-RNO-977615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates MCP/CR1-bound C4b/C3b (Rattus norvegicus)
REACT:R-HSA-427366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcription of intergenic spacer of the rRNA gene (Homo sapiens)
REACT:R-RNO-380949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK is dephosphorylated (Rattus norvegicus)
RHEA:25746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-pentahomomethionine <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O
REACT:R-HSA-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)
REACT:R-MMU-70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Mus musculus)
REACT:R-CFA-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Canis familiaris)
REACT:R-RNO-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Rattus norvegicus)
RHEA:46171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + pentanoate <=> AMP + diphosphate + pentanoyl-CoA
RHEA:39780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Rattus norvegicus)
RHEA:12008	skos:altLabel	"GPCR kinase"
RHEA:12008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)
RHEA:12008	skos:altLabel	"GPCRK"
RHEA:12008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[G-protein-coupled receptor] kinase"
RHEA:12008	skos:altLabel	"G protein-coupled receptor kinase"
RHEA:12008	skos:prefLabel	"[G-protein-coupled receptor] kinase"
REACT:R-DME-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Drosophila melanogaster)
RHEA:61089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + 2-oxoglutarate + O2 => (2R,3R)-dihydroquercetin + CO2 + succinate
REACT:R-CEL-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)
EC:3.4.24.65	skos:altLabel	"matrix metalloproteinase 12"
EC:3.4.24.65	skos:prefLabel	"macrophage elastase"
EC:3.4.24.65	skos:altLabel	"metalloelastase"
EC:3.4.24.65	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"macrophage elastase"
REACT:R-RNO-198621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates caspase-9 (Rattus norvegicus)
REACT:R-XTR-389352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Vav1 to CD28 (Xenopus tropicalis)
REACT:R-XTR-5654729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Xenopus tropicalis)
REACT:R-CFA-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Canis familiaris)
RHEA:47832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a + H2O = ganglioside GM1 + N-acetylneuraminate
REACT:R-DME-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Drosophila melanogaster)
REACT:R-BTA-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Bos taurus)
REACT:R-CEL-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
REACT:R-CFA-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Canis familiaris)
RHEA:58003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg3 + H(+) + UDP
REACT:R-RNO-9695890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Rattus norvegicus)
REACT:R-CFA-3928601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 and PIP2 bind WASL, activating it (Canis familiaris)
REACT:R-BTA-9669893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type I TKIs (Bos taurus)
RHEA:40845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-CoA + FADH2 => FAD + H(+) + octadecanoyl-CoA
RHEA:68979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate + NADP(+) <=> 7-oxoglycolithocholate + H(+) + NADPH
RHEA:53256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5610742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI1 (Sus scrofa)
REACT:R-MMU-6799959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP3,4 binds bacterial peptidoglycan (Mus musculus)
RHEA:49389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + validoxylamine A => H(+) + UDP + validamycin A
REACT:R-HSA-9617583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKII autophosphorylates (Homo sapiens)
REACT:R-DME-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Drosophila melanogaster)
RHEA:39870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol <=> 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)
REACT:R-SSC-5696356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSCAR binds collagen and SP-D (Sus scrofa)
REACT:R-XTR-2243926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of histidino-hydroxylysinonorleucine cross-links (Xenopus tropicalis)
REACT:R-RNO-561072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal uptake of organic cations (Rattus norvegicus)
REACT:R-MMU-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Mus musculus)
REACT:R-DME-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Drosophila melanogaster)
REACT:R-BTA-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Bos taurus)
REACT:R-HSA-6806732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface (Homo sapiens)
REACT:R-RNO-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Rattus norvegicus)
REACT:R-DRE-193054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cholesterol to 22beta-hydroxycholesterol (Danio rerio)
REACT:R-DRE-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
REACT:R-CFA-8851929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Canis familiaris)
EC:1.14.18.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase"
EC:1.14.18.8	skos:altLabel	"HCO 12alpha-hydroxylase"
EC:1.14.18.8	skos:altLabel	"CYP12"
EC:1.14.18.8	skos:prefLabel	"7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase"
EC:1.14.18.8	skos:altLabel	"sterol 12alpha-hydroxylase"
EC:1.14.18.8	skos:altLabel	"7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase"
REACT:R-MMU-5660665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 binds MALT (Mus musculus)
REACT:R-MMU-1605724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Mus musculus)
REACT:R-SSC-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Sus scrofa)
REACT:R-CFA-69600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)
REACT:R-CEL-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
REACT:R-DME-8848339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA5 hydrolyzes TAG (Drosophila melanogaster)
RHEA:33425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out)
REACT:R-MMU-1602454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proMMP9 binds TIMP1 (Mus musculus)
REACT:R-RNO-110221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by SMUG1 glycosylase (Rattus norvegicus)
REACT:R-SSC-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Sus scrofa)
RHEA:61303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-ribulose 1-phosphate <=> acetaldehyde + dihydroxyacetone phosphate
REACT:R-GGA-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
RHEA:25926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-8-ol
GO:0016750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-succinyltransferase activity
RHEA:49237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein](out) + sucrose => L-histidyl-[protein] + sucrose 6(G)-phosphate(in)
REACT:R-BTA-74743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-Y427-SHC1 from insulin receptor (Bos taurus)
REACT:R-XTR-374787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR neuropeptide receptor binds neuropeptides B and W (Xenopus tropicalis)
RHEA:55817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine
RHEA:33780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-kestotriose + sucrose => 6,6-kestotetraose + beta-D-glucose
REACT:R-HSA-1791066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HYOU1 (Homo sapiens)
REACT:R-BTA-70555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Bos taurus)
REACT:R-MMU-1855179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Mus musculus)
RHEA:11645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH
REACT:R-RNO-5665748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds RHOC:GTP (Rattus norvegicus)
RHEA:10687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-tyrosyl-[protein] <=> L-tyrosyl-[protein] + phosphate
RHEA:61021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA => 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine
REACT:R-HSA-6799815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind the FAS gene (Homo sapiens)
REACT:R-DRE-389350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 by pVav1 (Danio rerio)
RHEA:57429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anisole + O2 + reduced [NADH--hemoprotein reductase] => formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol
RHEA:21302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate => H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine
RHEA:30963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,9,9'-tri-cis-neurosporene + a quinone = 7,7',9,9'-tetra-cis-lycopene + a quinol
RHEA:64790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA + AMP + diphosphate => (E)-cinnamate + ATP + CoA
REACT:R-RNO-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Rattus norvegicus)
RHEA:10539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate
EC:3.2.1.50	skos:altLabel	"NAG"
EC:3.2.1.50	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-N-acetylglucosaminidase"
EC:3.2.1.50	skos:altLabel	"N-acetyl-alpha-glucosaminidase"
EC:3.2.1.50	skos:prefLabel	"alpha-N-acetylglucosaminidase"
RHEA:44252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:72875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A7 + malonyl-CoA = anthocyanin A9 + CoA
REACT:R-MMU-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Mus musculus)
REACT:R-RNO-5655170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 monoubiquitinates POLH (Rattus norvegicus)
REACT:R-BTA-428918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:G13 complex (Bos taurus)
REACT:R-SPO-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Schizosaccharomyces pombe)
REACT:R-RNO-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Rattus norvegicus)
GO:0052861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-(1,3)-beta-D-glucan 3-glucanohydrolase activity
GO:0052861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	laminaranase activity
GO:0052861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group
GO:0052861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	laminarinase activity
REACT:R-RNO-8851011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 polyubiquitinates PTEN (Rattus norvegicus)
RHEA:28493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + K(+)(in) <=> H(+)(out) + K(+)(out)
REACT:R-SPO-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Schizosaccharomyces pombe)
RHEA:39865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol
RHEA:50704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + NAD(+) = H(+) + NADH + propanal
REACT:R-BTA-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Bos taurus)
RHEA:69550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + phosphoethanolamine => H(+) + O-phospho-L-serine
REACT:R-DME-8862137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B2 oxidises estradiol (E2) to estrone (E1) (Drosophila melanogaster)
REACT:R-SSC-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Sus scrofa)
REACT:R-CFA-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Canis familiaris)
REACT:R-BTA-9692738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds HRH2 antagonists (Bos taurus)
GO:0018636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene 9,10-monooxygenase activity
RHEA:45316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin D2 = 11beta-prostaglandin F2 + NADP(+)
REACT:R-HSA-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Homo sapiens)
GO:0001864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentraxin binding
REACT:R-GGA-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Gallus gallus)
REACT:R-RNO-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Rattus norvegicus)
GO:0008808	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cardiolipin synthase 2 activity
GO:0008808	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cardiolipin synthetase 2 activity
GO:0008808	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cardiolipin synthetase activity
GO:0008808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphatidylglycerol synthase activity
GO:0008808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cardiolipin synthase activity
REACT:R-MMU-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Mus musculus)
REACT:R-SSC-8877760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Sus scrofa)
GO:0034279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate = 9beta-pimara-7,15-diene + diphosphate
GO:0034279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syn-pimara-7,15-diene synthase activity
GO:0034279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"syn-pimara-7,15-diene synthase"
GO:0034279	skos:altLabel	"9beta-pimara-7,15-diene synthase"
GO:0034279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity
GO:0034279	skos:prefLabel	"syn-pimara-7,15-diene synthase"
RHEA:59966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-octanoyl-L-seryl-[protein] => L-seryl-[protein] + octanoyl-CoA
RHEA:59995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + phloretate <=> (E)-4-coumarate + reduced [electron-transfer flavoprotein]
GO:0008811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloramphenicol O-acetyltransferase activity
GO:0008811	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity
GO:0008811	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chloramphenicol transacetylase activity
GO:0008811	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chloramphenicol acetyltransferase activity
GO:0008811	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chloramphenicol acetylase activity
GO:0008811	skos:prefLabel	"chloramphenicol O-acetyltransferase"
GO:0008811	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CAT I
GO:0008811	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CAT II
GO:0008811	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CAT III
GO:0008811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate + CoA
GO:0008811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chloramphenicol O-acetyltransferase"
RHEA:57325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]
GO:1990447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U2 snRNP binding
REACT:R-GGA-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Gallus gallus)
REACT:R-SSC-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Sus scrofa)
REACT:R-DRE-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Danio rerio)
REACT:R-XTR-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Xenopus tropicalis)
REACT:R-CEL-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Caenorhabditis elegans)
REACT:R-CFA-8851842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUC20 binds MET and inhibits GRB2 binding (Canis familiaris)
REACT:R-XTR-8961021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD binds with itself to form SFTPD 12mer (Xenopus tropicalis)
REACT:R-HSA-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Homo sapiens)
REACT:R-CEL-8848436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CDKN1B (Caenorhabditis elegans)
GO:0034888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endosulfan monooxygenase I activity
RHEA:59116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + O2 = [protein]-disulfide + H2O2
RHEA:42881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermine => H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine
RHEA:42700	skos:prefLabel	"pimeloyl-[acyl-carrier protein] methyl ester esterase"
RHEA:42700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pimeloyl-[acyl-carrier protein] methyl ester esterase"
RHEA:42700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H(+) + methanol
REACT:R-MMU-139920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tBID to mitochondria (Mus musculus)
RHEA:17794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-tRNA(Thr) => H(+) + L-alanine + tRNA(Thr)
REACT:R-HSA-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Homo sapiens)
REACT:R-SCE-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Saccharomyces cerevisiae)
REACT:R-DRE-8932633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Danio rerio)
REACT:R-BTA-9796368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 binds STUB1 (Bos taurus)
RHEA:65381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:50350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]
RHEA:66929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O => a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)
GO:0102481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity
RHEA:51297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(R)-S-oxide-[protein]
GO:0008863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formic hydrogen-lyase
GO:0008863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate dehydrogenase (NAD)
GO:0008863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formic acid dehydrogenase
GO:0008863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate dehydrogenase (NAD+) activity
GO:0008863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate hydrogenlyase
GO:0008863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-formate dehydrogenase
GO:0008863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent formate dehydrogenase
GO:0008863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate-NAD oxidoreductase
REACT:R-XTR-5423117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates MeK21-histone H4 (Xenopus tropicalis)
REACT:R-HSA-2993784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO2 to UBA2:SAE1 (Homo sapiens)
GO:0015565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine efflux permease activity
GO:0015565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine(in) = L-threonine(out)
GO:0015565	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine export protein
GO:0015565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine efflux transmembrane transporter activity
GO:0015565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine export transporter activity
EC:3.4.24.44	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"atrolysin E"
EC:3.4.24.44	skos:altLabel	"hemorrhagic toxin e"
EC:3.4.24.44	skos:altLabel	"Crotalus atrox metalloendopeptidase e"
EC:3.4.24.44	skos:prefLabel	"atrolysin E"
RHEA:61562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:62961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol(in) => 7-dehydrocholesterol(out)
REACT:R-HSA-8852716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin, ELANE cleave C5 (Homo sapiens)
RHEA:40146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H2O <=> (9Z,12Z)-octadecadienoate + CoA + H(+)
REACT:R-HSA-9606883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD19 is phosphorylated (Homo sapiens)
RHEA:18605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)
RHEA:18605	skos:prefLabel	"scyllo-inosamine 4-kinase"
RHEA:18605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scyllo-inosamine 4-kinase"
REACT:R-RNO-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Rattus norvegicus)
REACT:R-HSA-2426164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the SC5DL promoter (Homo sapiens)
REACT:R-DME-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Drosophila melanogaster)
RHEA:13544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetrathionate <=> H(+) + sulfate + sulfur + thiosulfate
REACT:R-RNO-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Rattus norvegicus)
REACT:R-BTA-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Bos taurus)
RHEA:53167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)
REACT:R-HSA-6783883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P6C transforms to 2AMAS (Homo sapiens)
REACT:R-BTA-374251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARC  is a non-specific receptor for many chemokines (Bos taurus)
RHEA:63898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoaspulvinone E => aspulvinone E + hnu
REACT:R-DDI-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Dictyostelium discoideum)
REACT:R-DRE-8964271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in PIP3:BTK:G beta-gamma complex is activated (Danio rerio)
REACT:R-DRE-2130500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of MHC II:Ii complex in to the plasma membrane (Danio rerio)
RHEA:37602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O
RHEA:46120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0106331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate
GO:0106331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialate 4-O-acetylesterase activity
REACT:R-DME-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Drosophila melanogaster)
REACT:R-RNO-9632918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Rattus norvegicus)
REACT:R-MMU-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Mus musculus)
REACT:R-HSA-6808496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)
RHEA:37377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
REACT:R-SSC-8849042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS3 (Sus scrofa)
RHEA:32073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-yl diphosphate => geranylgeranyl diphosphate
REACT:R-HSA-2029451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Homo sapiens)
REACT:R-RNO-6785986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)
REACT:R-GGA-216072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Gallus gallus)
REACT:R-HSA-2426259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Homo sapiens)
REACT:R-BTA-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Bos taurus)
REACT:R-GGA-1222491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoferrin scavenges iron ions (Gallus gallus)
RHEA:47958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + maleate + pyruvate => 3-maleylpyruvate + H2O
RHEA:70019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + typhasterol = 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-201445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Rattus norvegicus)
REACT:R-XTR-5250938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Xenopus tropicalis)
REACT:R-DRE-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Danio rerio)
REACT:R-DME-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Drosophila melanogaster)
REACT:R-GGA-5654647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
REACT:R-XTR-5686335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF2RA:CSF2RB binds SFTPs (Xenopus tropicalis)
GO:0005298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline:sodium symporter activity
GO:0005298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/proline symporter activity
RHEA:32196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18,18-diol => abieta-7,13-dien-18-al + H2O
REACT:R-HSA-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Homo sapiens)
REACT:R-HSA-380283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
REACT:R-HSA-9612483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1,2,3 bind the NAB2 promoter (Homo sapiens)
RHEA:66316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O = alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)
RHEA:49869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid + a quinone => (+)-dehydrodiconiferyl acid ketone + a quinol
REACT:R-HSA-71223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2 (Homo sapiens)
REACT:R-CEL-9612501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates CREB1 (Caenorhabditis elegans)
REACT:R-RNO-5692775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Rattus norvegicus)
RHEA:61700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-5'-AMP + holo-[peptidyl-carrier protein] = AMP + glycyl-[peptidyl-carrier protein] + H(+)
RHEA:65508	skos:prefLabel	"pre-mycofactocin synthase"
RHEA:65508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pre-mycofactocin synthase"
RHEA:65508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 = H2O2 + NH4(+) + pre-mycofactocin
RHEA:39301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH
REACT:R-SCE-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Saccharomyces cerevisiae)
REACT:R-HSA-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)
RHEA:62639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O
REACT:R-HSA-8938981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3 gene transcription is stimulated by RUNX1 and ELF1 (Homo sapiens)
RHEA:14970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-aconitate => (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine
REACT:R-SCE-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Saccharomyces cerevisiae)
RHEA:70841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-histidine(in) + Na(+)(in) => L-arginine(in) + L-histidine(out) + Na(+)(out)
RHEA:51942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1Z,2S)-2-methylbutanal oxime => (1E,2S)-2-methylbutanal oxime
REACT:R-CFA-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Canis familiaris)
REACT:R-GGA-420595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-2:Nectin 3 trans heterodimer interaction (Gallus gallus)
RHEA:39215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexacosenoyl-CoA + H(+) + NADPH = hexacosanoyl-CoA + NADP(+)
REACT:R-HSA-5602170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol (Homo sapiens)
REACT:R-BTA-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Bos taurus)
RHEA:42037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NAD(+) => 7-oxolithocholate + H(+) + NADH
RHEA:23411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + precorrin-6B <=> 2 H(+) + NADPH + precorrin-6A
REACT:R-SPO-8851550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)
REACT:R-RNO-5682858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate H2AFX (Rattus norvegicus)
RHEA:34761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycerol 2-phosphate(in) + H(+) + phosphate => ATP + glycerol 2-phosphate(out) + H2O
RHEA:32064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGDP + H2O => 8-oxo-dGMP + H(+) + phosphate
RHEA:38447	skos:altLabel	"beta-L-arabinobiosidase"
RHEA:38447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O = 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose
RHEA:38447	skos:prefLabel	"(Ara-f)3-Hyp beta-L-arabinobiosidase"
RHEA:38447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(Ara-f)3-Hyp beta-L-arabinobiosidase"
RHEA:52077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)
REACT:R-SPO-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Schizosaccharomyces pombe)
RHEA:71962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + oxaloacetate(out) <=> 3 Na(+)(in) + oxaloacetate(in)
RHEA:44650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O
REACT:R-CFA-178208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF2 (Canis familiaris)
REACT:R-SSC-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Sus scrofa)
REACT:R-HSA-9674558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 (Homo sapiens)
RHEA:68659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxocholesterol + H(+) + NADPH <=> 7beta-hydroxycholesterol + NADP(+)
RHEA:65946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + CTP + S-adenosyl-L-methionine
REACT:R-DRE-5672954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Danio rerio)
REACT:R-DDI-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)
REACT:R-HSA-1022133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Homo sapiens)
RHEA:46485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
REACT:R-MMU-9731632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Mus musculus)
REACT:R-SSC-211247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DNA by DFF40 (Sus scrofa)
RHEA:44806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-9 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+)
REACT:R-RNO-5690669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds itself to form homo-oligomers (Rattus norvegicus)
REACT:R-HSA-5690701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 binds p-CD22 (Homo sapiens)
RHEA:46446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (11Z)-hexadecenoyl-CoA + AH2 + O2
RHEA:25801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine + O2 => 3-acetamidopropanal + H2O2 + spermidine
REACT:R-HSA-4085087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Homo sapiens)
REACT:R-GGA-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Gallus gallus)
REACT:R-HSA-5336454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMGT1 transports Mg2+ from cytosol to Golgi lumen (Homo sapiens)
REACT:R-SSC-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Sus scrofa)
RHEA:68111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glucitol + NAD(+) <=> H(+) + keto-L-fructose + NADH
EC:3.2.1.103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"keratan-sulfate endo-1,4-beta-galactosidase"
EC:3.2.1.103	skos:altLabel	"endo-beta-galactosidase"
EC:3.2.1.103	skos:prefLabel	"keratan-sulfate endo-1,4-beta-galactosidase"
REACT:R-MMU-374723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nociceptin receptor binds to nociceptin (Mus musculus)
REACT:R-SPO-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Schizosaccharomyces pombe)
RHEA:37458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-469659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A1 dehydrogenates TEST to DHTEST (Homo sapiens)
RHEA:23096	skos:prefLabel	"hydroxymethylpyrimidine kinase"
RHEA:23096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)
RHEA:23096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxymethylpyrimidine kinase"
REACT:R-SSC-110248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 3-methyladenine by MPG glycosylase  (Sus scrofa)
RHEA:29026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-fucose(in) <=> H(+)(out) + L-fucose(out)
REACT:R-DME-109530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Drosophila melanogaster)
RHEA:37165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate
REACT:R-MMU-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Mus musculus)
RHEA:33382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyeicosasphinganine 1-phosphate + H2O <=> (4R)-hydroxyeicosasphinganine + phosphate
RHEA:18632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NAD(+) <=> ADP + H(+) + NADP(+)
REACT:R-DME-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)
REACT:R-CEL-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Caenorhabditis elegans)
REACT:R-DME-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Drosophila melanogaster)
REACT:R-DDI-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Dictyostelium discoideum)
RHEA:14141	skos:prefLabel	"adenylyl-sulfate reductase (glutathione)"
RHEA:14141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylyl-sulfate reductase (glutathione)"
RHEA:14141	skos:altLabel	"plant-type 5'-adenylylsulfate reductase"
RHEA:14141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + glutathione disulfide + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + 2 glutathione
RHEA:14141	skos:altLabel	"AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming)"
RHEA:14141	skos:altLabel	"5'-adenylylsulfate reductase"
REACT:R-CFA-209960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diiodinated tyrosine can be deiodinated (Canis familiaris)
REACT:R-GGA-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Gallus gallus)
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proximal promoter sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enhancer sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	core promoter proximal region sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	core promoter proximal region DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enhancer binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-regulatory region sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type proximal promoter sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type cis-regulatory region sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase enhancer sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	promoter proximal region sequence-specific DNA binding
GO:0000987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-regulatory region binding
REACT:R-HSA-375157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with contactin-2 (Homo sapiens)
RHEA:37662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + methanol <=> CoA + O-methyl anthranilate
RHEA:58420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH
RHEA:25705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:30977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 AH2 + all-trans-3,4-didehydrolycopene => 15-cis-phytoene + 5 A
REACT:R-BTA-9700156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK dimer binds IRS1 (Bos taurus)
EC:4.99.1.3	skos:prefLabel	"sirohydrochlorin cobaltochelatase"
EC:4.99.1.3	skos:altLabel	"anaerobic cobalt chelatase"
EC:4.99.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sirohydrochlorin cobaltochelatase"
EC:4.99.1.3	skos:altLabel	"cobaltochelatase"
GO:0047084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)
GO:0047084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity
GO:0047084	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity
GO:0047084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyltetrahydroprotoberberine 14-monooxygenase activity
GO:0047084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyltetrahydroprotoberberine 14-hydroxylase activity
REACT:R-HSA-448948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E proteins by p38 MAPK (Homo sapiens)
RHEA:64815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + S-(2-aminoethyl)-homocysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-homocysteine
REACT:R-RNO-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Rattus norvegicus)
RHEA:39533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH
REACT:R-GGA-5654409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS2 (Gallus gallus)
REACT:R-RNO-983424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of COPII coated vesicle (Rattus norvegicus)
REACT:R-HSA-917835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from holoTF:TFRC dimer (Homo sapiens)
RHEA:47413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA
GO:0008318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein prenyltransferase activity
GO:0070052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	collagen V binding
REACT:R-SPO-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Schizosaccharomyces pombe)
RHEA:20106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-fructose 6-phosphate => AMP + beta-D-fructose 1,6-bisphosphate + H(+)
REACT:R-CEL-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)
RHEA:18906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphonoacetaldehyde => acetaldehyde + H(+) + phosphate
GO:0008902	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylpyrimidine kinase (phosphorylating)
GO:0008902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylpyrimidine kinase activity
GO:0008902	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity
REACT:R-XTR-921155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from the receptor complex (Xenopus tropicalis)
REACT:R-SSC-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Sus scrofa)
RHEA:53798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + ursodeoxycholoyl-CoA => deoxycholoyl-CoA + ursodeoxycholate
RHEA:33106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> alpha-muurolene + diphosphate
REACT:R-HSA-9682718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp15 forms a hexamer (Homo sapiens)
RHEA:30455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O = (-)-geosmin
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrolipoyl dehydrogenase activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoic acid dehydrogenase activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoylprotein reduction
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrolipoate dehydrogenase activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoamide dehydrogenase activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-protein activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoamide reduction
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3 component of alpha-ketoacid dehydrogenase complexes activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diaphorase activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrothioctic dehydrogenase activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoamide oxidoreductase (NADH) activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	LDP-Val activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoyl dehydrogenase activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoamide reductase (NADH) activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoamide:NAD+ oxidoreductase
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	LDP-Glc activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoamide reductase activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoic dehydrogenase activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine-cleavage system L-protein activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoate dehydrogenase activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoamide dehydrogenase (NADH) activity
GO:0004148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase
REACT:R-HSA-199587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR2DS1 interacting with HLA-C group 2 (Cw4) (Homo sapiens)
RHEA:56999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-apiose <=> apulose
RHEA:23332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglycerate kinase (GTP)"
RHEA:23332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GTP = (2R)-3-phospho-glyceroyl phosphate + GDP
RHEA:23332	skos:prefLabel	"phosphoglycerate kinase (GTP)"
REACT:R-HSA-5693012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF15 binds TNFRSF25 (Homo sapiens)
RHEA:31861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutinol => (S)-2,3-epoxysqualene
GO:0140097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalytic activity, acting on DNA
REACT:R-CEL-8950181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y693-STAT4 dimer translocates to the nucleus (Caenorhabditis elegans)
REACT:R-DME-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Drosophila melanogaster)
REACT:R-DME-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Drosophila melanogaster)
REACT:R-MMU-6782106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates SNX3, CFTR (Mus musculus)
GO:0004632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopantothenoylcysteine synthetase activity
GO:0004632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopantothenate--cysteine ligase activity
GO:0004632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopantothenate-cysteine ligase activity
GO:0004632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-4'-phosphopantothenate:L-cysteine ligase activity
REACT:R-CEL-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Caenorhabditis elegans)
REACT:R-HSA-182795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase H-mediated degradation of the template strand (Homo sapiens)
RHEA:10078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactose + D-glucose => H2O + lactose
RHEA:36148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + benzyl alcohol => benzyl acetate + CoA
RHEA:43059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH <=> 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)
RHEA:21106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholesterol + A + H2O => AH2 + cholesterol + O2
REACT:R-XTR-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Xenopus tropicalis)
RHEA:65911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + pyruvate <=> H2O + L-alanine + xanthurenate
RHEA:12590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)) + H(+) + UDP => ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine
RHEA:52439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA
REACT:R-HSA-909724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IFNAR1 (Homo sapiens)
REACT:R-DME-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Drosophila melanogaster)
REACT:R-DRE-6787533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Danio rerio)
REACT:R-CFA-9708558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Canis familiaris)
RHEA:14010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dimethylallyl diphosphate => (R,R)-chrysanthemyl diphosphate + diphosphate
RHEA:71743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + hexanedioate(in) = 2-oxoglutarate(in) + hexanedioate(out)
REACT:R-XTR-6794346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind NLGNs (Xenopus tropicalis)
RHEA:71881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide => 2'-deoxyguanosine + NAD(+)
REACT:R-HSA-1449574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A4 (GLUT4) vesicle fuses with the plasma membrane (Homo sapiens)
REACT:R-GGA-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Gallus gallus)
GO:0047271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosaminoglycan galactosyltransferase activity
GO:0047271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity
GO:0047271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:glycosaminoglycan D-galactosyltransferase activity
GO:0047271	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:glycosaminoglycan D-galactosyltransferase activity
REACT:R-XTR-8863494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASICs bind STOML3, (STOM) (Xenopus tropicalis)
RHEA:25883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-dopa + O2 <=> 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)
REACT:R-CEL-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Caenorhabditis elegans)
REACT:R-MMU-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Mus musculus)
RHEA:28330	skos:prefLabel	"inosine/xanthosine triphosphatase"
RHEA:28330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ITP = H(+) + IDP + phosphate
RHEA:28330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inosine/xanthosine triphosphatase"
RHEA:28330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XTP = H(+) + phosphate + XDP
RHEA:50522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein]
GO:0030754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity
GO:0030754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 4'-O-methyltransferase activity
GO:0030754	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	flavonoid O-methyltransferase activity
GO:0030754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonoid methyltransferase activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phanerochaete chrysosporium cellobiose oxidoreductase activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CBOR activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cellobiose-quinone oxidoreductase activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellobiose dehydrogenase (acceptor) activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiose:oxygen 1-oxidoreductase activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiose:(acceptor) 1-oxidoreductase activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cellobiose dehydrogenase (quinone) activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiose:acceptor 1-oxidoreductase activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiose oxidoreductase activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiose oxidase activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiose dehydrogenase activity
GO:0047735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDH activity
GO:0102680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campest-4-en-3-one hydroxylase activity
REACT:R-MMU-8851538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside triphosphates (Mus musculus)
REACT:R-SSC-5577234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Sus scrofa)
REACT:R-BTA-175983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfer CH3 from AdoMet to 3,4DHBNZ (Bos taurus)
RHEA:11510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2
RHEA:16153	skos:altLabel	"amine oxidase"
RHEA:16153	skos:prefLabel	"primary-amine oxidase"
RHEA:16153	skos:altLabel	"copper amine oxidase"
RHEA:16153	skos:altLabel	"CAO"
RHEA:16153	skos:altLabel	"benzylamine oxidase"
RHEA:16153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"primary-amine oxidase"
RHEA:16153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)
RHEA:16153	skos:altLabel	"amine oxidase (copper-containing)"
GO:0050043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lacticoracemase activity
GO:0050043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyacid racemase activity
GO:0050043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactic acid racemase activity
GO:0050043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate racemase activity
REACT:R-GGA-193646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF binding to p75NTR inactivates RHOA (Gallus gallus)
REACT:R-CFA-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Canis familiaris)
REACT:R-HSA-199910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates ATF1 (Homo sapiens)
REACT:R-RNO-2731141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds fibronectin (Rattus norvegicus)
GO:0003747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation release factor activity
RHEA:72595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) = H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)
REACT:R-GGA-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Gallus gallus)
REACT:R-RNO-2855020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Rattus norvegicus)
RHEA:58617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-octanoyl-(2S)-hydroxyglycine => glyoxylate + octanamide
RHEA:66976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-abequose:alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase"
RHEA:66976	skos:prefLabel	"CDP-abequose:alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase"
RHEA:66976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)
RHEA:64602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base
REACT:R-HSA-8848370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL18 binds IL18R1 (Homo sapiens)
REACT:R-XTR-71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Xenopus tropicalis)
GO:0031837	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	substance K receptor ligand
GO:0031837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	substance K receptor binding
GO:0031837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurokinin-A receptor binding
EC:4.1.3.42	skos:altLabel	"hydroxyketoglutaric aldolase"
EC:4.1.3.42	skos:prefLabel	"(4S)-4-hydroxy-2-oxoglutarate aldolase"
EC:4.1.3.42	skos:altLabel	"2-keto-4-hydroxyglutaric aldolase"
EC:4.1.3.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(4S)-4-hydroxy-2-oxoglutarate aldolase"
EC:4.1.3.42	skos:altLabel	"4-hydroxy-2-ketoglutaric aldolase"
RHEA:30606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + A <=> AH2 + all-trans-phytofluene
RHEA:44134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine => 2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine
REACT:R-HSA-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Homo sapiens)
REACT:R-HSA-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Homo sapiens)
REACT:R-SSC-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Sus scrofa)
GO:0102045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chlorobenzoate-3,4-oxygenase activity
GO:0005007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibroblast growth factor receptor activity
GO:0005007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGF-activated receptor activity
GO:0005007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR
GO:0005007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibroblast growth factor-activated receptor activity
GO:0005007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGF receptor activity
RHEA:61235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine + O2 <=> (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)
REACT:R-DME-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Drosophila melanogaster)
REACT:R-HSA-1250488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer (Homo sapiens)
RHEA:29561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phospho-alpha-D-glucuronate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucuronate
RHEA:21161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ADP + oxaloacetate + phosphate => ATP + citrate + CoA
RHEA:58549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine
RHEA:13906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP
RHEA:72618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-valine(out) <=> H(+)(in) + L-alanyl-L-valine(in)
RHEA:70749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine
REACT:R-DRE-1247668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A binds O2, releasing H+ and CO2 (Danio rerio)
REACT:R-CEL-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Caenorhabditis elegans)
GO:0102464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zeaxanthin 2-beta-hydroxylase activity
RHEA:34094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-phosphooxy-L-lysine + H2O <=> (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate
RHEA:12978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-phosphocreatine => creatine + phosphate
RHEA:72371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + succinate(in) = dehydroepiandrosterone 3-sulfate(in) + succinate(out)
RHEA:15008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A1 + O2 <=> CO2 + gibberellin A8 + succinate
GO:0004736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic carboxylase activity
GO:0004736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate carboxylase activity
GO:0004736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:carbon-dioxide ligase (ADP-forming)
RHEA:21717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O
RHEA:24725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)
RHEA:56341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:65164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + hexan-3-ol = CoA + hexan-3-yl benzoate
RHEA:70701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in) => H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out)
REACT:R-MMU-3234094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TFAP2C with SUMO1 (Mus musculus)
RHEA:64739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxynonanal + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH
RHEA:36543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate
RHEA:36543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycothiol S-conjugate amidase"
RHEA:36543	skos:prefLabel	"mycothiol S-conjugate amidase"
RHEA:47571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GD1b (d18:1(4E)) + H(+) + UDP
RHEA:35096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline => acetaldehyde + trimethylamine
RHEA:72980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	didemethylasterriquinone D + dimethylallyl diphosphate => asterriquinone C1 + diphosphate
REACT:R-GGA-174097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdh1 (Gallus gallus)
RHEA:25440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = delta-selinene + diphosphate
REACT:R-BTA-9014627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDS dimers:PXLP dehydrate L-Thr to 2AA (Bos taurus)
RHEA:30121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + H(+) + holo-[ACP] => dodecanoyl-[ACP] + H2O
GO:0047522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity
GO:0047522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin 13-oxidase activity
RHEA:43577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate
REACT:R-HSA-1168445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B binds the GH receptor complex (Homo sapiens)
RHEA:66295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)
REACT:R-HSA-9686336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 3a oligomerizes (Homo sapiens)
REACT:R-MMU-5688834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds VCP (Mus musculus)
GO:0008281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfonylurea receptor activity
GO:0008281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphonylurea receptor activity
REACT:R-MMU-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Mus musculus)
RHEA:11554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycerol + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + H2O
RHEA:65745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + decyl sulfate + O2 => CO2 + decanal + H(+) + succinate + sulfate
REACT:R-HSA-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Homo sapiens)
REACT:R-HSA-389523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTLA interacts with HVEM (Homo sapiens)
REACT:R-RNO-1606583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Rattus norvegicus)
EC:3.4.21.60	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scutelarin"
EC:3.4.21.60	skos:altLabel	"taipan activator"
EC:3.4.21.60	skos:prefLabel	"scutelarin"
REACT:R-RNO-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Rattus norvegicus)
REACT:R-GGA-9679029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds HCQ (Gallus gallus)
RHEA:51191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide + superoxide <=> peroxynitrite
REACT:R-CEL-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Caenorhabditis elegans)
REACT:R-BTA-5684275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
RHEA:57474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP => (E)-4-coumarate + UDP-alpha-D-glucose
RHEA:60951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + S-adenosyl-L-methionine <=> (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Caenorhabditis elegans)
RHEA:51427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate
REACT:R-BTA-8983059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Bos taurus)
RHEA:25334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinyl-tRNA(Cys) = H(+) + L-cysteine + tRNA(Cys)
RHEA:25334	skos:prefLabel	"L-cysteinyl-tRNA(Cys) hydrolase"
RHEA:25334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-cysteinyl-tRNA(Cys) hydrolase"
RHEA:25334	skos:altLabel	"Cys-tRNA(Cys) deacylase"
RHEA:69975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] = (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-9686524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6-PPP6R3 dephosphorylates TERF2 (Rattus norvegicus)
REACT:R-HSA-170977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 is phosphorylated by active TrkA receptor (Homo sapiens)
REACT:R-RNO-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Rattus norvegicus)
REACT:R-MMU-9653585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Farn-Me KRAS4B binds calmodulin (Mus musculus)
REACT:R-DME-450434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)
REACT:R-CFA-5693549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Canis familiaris)
REACT:R-BTA-2404195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Bos taurus)
REACT:R-CFA-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Canis familiaris)
RHEA:70532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP
RHEA:50351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] <=> a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
RHEA:59519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylsalicylate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate
REACT:R-SSC-5591040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves Factor Va intermediate form for Factor Va (Sus scrofa)
REACT:R-MMU-2065539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:Importin beta-1 dissociates (Mus musculus)
REACT:R-MMU-8854908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates RET:GDNF:GFRA dimer (Mus musculus)
REACT:R-CFA-190427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1b (Canis familiaris)
REACT:R-CFA-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Canis familiaris)
REACT:R-DME-432559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PER is phosphorylated by DCO (Drosophila melanogaster)
RHEA:67676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine
RHEA:68027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + presqualene monophosphate <=> phosphate + presqualene alcohol
REACT:R-DRE-8936608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Danio rerio)
RHEA:20252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine <=> D-alanine
RHEA:59285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O => D-glucose + N-octadecanoylsphing-4-enine
RHEA:25490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate
RHEA:48362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxy fatty acid + H2O => a 1,2-saturated fatty acid + H2O2
RHEA:67946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxohexadecanoate + H2O2 => 2-hydroxyhexadecanoate + O2
RHEA:20715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-CoA + H(+) + L-alanine <=> (8S)-8-amino-7-oxononanoate + CO2 + CoA
REACT:R-CFA-193695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK interacts with TRAF6 (Canis familiaris)
REACT:R-DME-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Drosophila melanogaster)
RHEA:15714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactoside + acetyl-CoA => a 6-acetyl-beta-D-galactoside + CoA
GO:0052760	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNP reductase activity
GO:0052760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent 2,4-dinitrophenol reductase activity
GO:0052760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent 2,4-dinitrophenol hydride transferase activity
RHEA:12493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine => D-methionine
REACT:R-XTR-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Xenopus tropicalis)
RHEA:24439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + methanophenazine <=> dihydromethanophenazine
RHEA:20081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methylhexanamide = hexanoate + methylamine
RHEA:20081	skos:prefLabel	"alkylamidase"
RHEA:20081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkylamidase"
RHEA:37355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + uridine 2'-phosphate = phosphate + uridine
RHEA:22048	skos:altLabel	"PTPS"
RHEA:22048	skos:prefLabel	"6-pyruvoyltetrahydropterin synthase"
RHEA:22048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-pyruvoyltetrahydropterin synthase"
RHEA:22048	skos:altLabel	"6-pyruvoyl tetrahydrobiopterin synthase"
RHEA:22048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate
RHEA:49366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+)
REACT:R-GGA-8948230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P3HB binds 4-Hyp-collagen propeptides (Gallus gallus)
GO:0003951	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide kinase activity
GO:0003951	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:NAD+ 2'-phosphotransferase activity
GO:0003951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ kinase activity
GO:0003951	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPN kinase activity
GO:0003951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD kinase activity
GO:0003951	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide kinase (phosphorylating)
GO:0003951	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADK
REACT:R-CEL-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Caenorhabditis elegans)
RHEA:56543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA
GO:0103047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl beta-D-glucoside 6-phosphate glucohydrolase activity
RHEA:66179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurochenodeoxycholate 3-sulfate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)
REACT:R-MMU-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Mus musculus)
REACT:R-CFA-6788912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)
REACT:R-CFA-8850997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 binds PTEN (Canis familiaris)
RHEA:25335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinyl-tRNA(Cys) => H(+) + L-cysteine + tRNA(Cys)
REACT:R-RNO-2029465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)
REACT:R-GGA-8985929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Gallus gallus)
REACT:R-RNO-9026006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Rattus norvegicus)
RHEA:46474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-RNO-8950456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B dimerizes (Rattus norvegicus)
REACT:R-SCE-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Saccharomyces cerevisiae)
GO:0015576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucitol permease activity
GO:0015576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbitol permease activity
GO:0015576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbitol transmembrane transporter activity
GO:0015576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucitol transporter activity
RHEA:11343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + H(+) <=> 4-guanidinobutanal + CO2
REACT:R-BTA-350168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Bos taurus)
REACT:R-CFA-5685011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR activation at DNA DSBs (Canis familiaris)
REACT:R-SPO-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Schizosaccharomyces pombe)
REACT:R-CFA-6799202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Canis familiaris)
RHEA:20018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 => 5,10-methylenetetrahydromethanopterin + H(+)
RHEA:32855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-MMU-5218809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)
REACT:R-CFA-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Canis familiaris)
REACT:R-CFA-2993763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Canis familiaris)
REACT:R-RNO-429529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin binding to GP1b:IX:V (Rattus norvegicus)
RHEA:70554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP
RHEA:15898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanoate + H2O => 4-aminobutanoate + acetate
RHEA:20323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline-2-carboxylate + H(+) + NADH => L-proline + NAD(+)
REACT:R-GGA-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Gallus gallus)
REACT:R-SSC-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Sus scrofa)
REACT:R-XTR-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Xenopus tropicalis)
RHEA:18914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)
REACT:R-BTA-73912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Bos taurus)
RHEA:69081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + 2 H(+) + NADH
RHEA:25680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys) => ATP + O-phospho-L-serine + tRNA(Cys)
REACT:R-GGA-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Gallus gallus)
RHEA:49765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylenediaminetriacetate + FMNH2 + O2 => ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O
REACT:R-HSA-9711016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING (Homo sapiens)
RHEA:23718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA => (3Z)-dodecenoyl-CoA
RHEA:43311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycerol + ATP <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SSC-194017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 11DCORST to CORST (Sus scrofa)
RHEA:61323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide
RHEA:33067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine 1-phosphate + H2O = (4R)-hydroxysphinganine + phosphate
RHEA:47637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine + NADP(+) => 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)
RHEA:16817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH
RHEA:16332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
REACT:R-HSA-933538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IRF7 to TRAF6 (Homo sapiens)
REACT:R-HSA-213407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from SLP-76 (Homo sapiens)
RHEA:13097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxyacyl-[acyl-carrier-protein] dehydratase"
RHEA:13097	skos:altLabel	"beta-hydroxyoctanoyl-ACP-dehydrase"
RHEA:13097	skos:altLabel	"beta-hydroxyoctanoyl thioester dehydratase"
RHEA:13097	skos:altLabel	"(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase"
RHEA:13097	skos:altLabel	"beta-hydroxyoctanoyl-acyl carrier protein dehydrase"
RHEA:13097	skos:prefLabel	"3-hydroxyacyl-[acyl-carrier-protein] dehydratase"
RHEA:13097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O
RHEA:13097	skos:altLabel	"3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase"
RHEA:13097	skos:altLabel	"D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase"
REACT:R-HSA-9730967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 stimulates SMAD7 gene transcription (Homo sapiens)
EC:3.4.11.13	skos:prefLabel	"clostridial aminopeptidase"
EC:3.4.11.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"clostridial aminopeptidase"
EC:3.4.11.13	skos:altLabel	"Clostridium histolyticum aminopeptidase"
RHEA:27459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-diiodo-L-tyrosine + H(+) + NADPH => 3-iodo-L-tyrosine + iodide + NADP(+)
REACT:R-XTR-9663492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL dissociates from GSTA1, FABP1 (Xenopus tropicalis)
GO:0047916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-6-deoxy-D-talose 4-dehydrogenase activity
GO:0047916	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphospho-6-deoxy-D-talose dehydrogenase activity
GO:0047916	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity
RHEA:70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside => a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol
REACT:R-BTA-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Bos taurus)
REACT:R-DDI-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Dictyostelium discoideum)
RHEA:44985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 3-methylbutanoyl-CoA => CoA + O-3-methylbutanoyl-(R)-carnitine
REACT:R-GGA-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Gallus gallus)
RHEA:54489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine
REACT:R-CFA-391153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds GRB2-1 (Canis familiaris)
REACT:R-XTR-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Xenopus tropicalis)
REACT:R-RNO-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Rattus norvegicus)
REACT:R-CFA-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Canis familiaris)
RHEA:55122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+) => 4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH
RHEA:30910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) <=> 2-methylbutanoyl-CoA + CO2 + NADH
RHEA:29857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine
REACT:R-HSA-2993781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO3 to UBA2:SAE1 (Homo sapiens)
REACT:R-XTR-9634846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNTL (BMAL1) (Xenopus tropicalis)
REACT:R-HSA-2466706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective OPN1MW causes DCB and BCM (Homo sapiens)
REACT:R-XTR-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)
RHEA:69329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate => 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur
RHEA:17853	skos:prefLabel	"L-sorbose oxidase"
RHEA:17853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-sorbose oxidase"
RHEA:17853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-sorbose + O2 = 5-dehydro-D-fructose + H2O2
REACT:R-BTA-9700168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates IRS1 (Bos taurus)
RHEA:29392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O => diphosphate + GMP + H(+)
REACT:R-SSC-2172123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SIGLEC14/15/16 and DAP12 (Sus scrofa)
REACT:R-GGA-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Gallus gallus)
REACT:R-XTR-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Xenopus tropicalis)
REACT:R-DDI-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Dictyostelium discoideum)
REACT:R-CFA-1655879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiosulfate can transfer its sulfur atom to glutathione (Canis familiaris)
REACT:R-DME-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Drosophila melanogaster)
REACT:R-DME-354087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2 to p-PTK2 (Drosophila melanogaster)
REACT:R-HSA-1028821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Phospho IRF3 or phospho IRF7 (Homo sapiens)
RHEA:54733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-BTA-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Bos taurus)
REACT:R-DRE-5618110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Danio rerio)
REACT:R-HSA-9006507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIN2A gene expression is stimulated by MECP2 (Homo sapiens)
GO:0016250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-sulfoglucosamine sulfohydrolase activity
GO:0016250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfoglucosamine sulfamidase activity
GO:0016250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)
GO:0016250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-sulphoglucosamine sulphohydrolase activity
GO:0016250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-sulfo-D-glucosamine sulfohydrolase activity
GO:0016250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulphamidase activity
GO:0016250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin sulfamidase activity
REACT:R-CEL-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)
RHEA:67199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylserotonin <=> acetate + serotonin
REACT:R-XTR-5607728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Xenopus tropicalis)
RHEA:63930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-DRE-5690845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNIPs bind TNFAIP3 (A20) (Danio rerio)
RHEA:25662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = alpha-pinene + diphosphate
REACT:R-SSC-8851436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFHR dimers bind C3b (Sus scrofa)
REACT:R-HSA-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Homo sapiens)
REACT:R-HSA-5672972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
REACT:R-DDI-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Dictyostelium discoideum)
REACT:R-GGA-202939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of E-Cadherin (Gallus gallus)
REACT:R-HSA-8951498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Homo sapiens)
REACT:R-HSA-975134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
RHEA:55888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[aequorin]--dioxetanone = [excited state blue fluorescent protein] + CO2
RHEA:63444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0
REACT:R-MMU-381412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP2 binds IGF forming IGF:IGFBP2 (Mus musculus)
RHEA:32119	skos:prefLabel	"validamine 7-phosphate valienyltransferase"
RHEA:32119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-valienol + validamine 7-phosphate = GDP + H(+) + validoxylamine A 7'-phosphate
RHEA:32119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"validamine 7-phosphate valienyltransferase"
RHEA:52802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid => acetoacetyl-CoA + ATP + L-isoleucine
REACT:R-XTR-964759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alternative endo-mannosidase I route (Xenopus tropicalis)
REACT:R-RNO-8851877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Rattus norvegicus)
REACT:R-RNO-6798528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Mn2+ (Rattus norvegicus)
RHEA:64460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate
REACT:R-SSC-8875540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 recruits CRK,CRKL to MET (Sus scrofa)
REACT:R-MMU-168915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)
REACT:R-HSA-8953461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)
REACT:R-RNO-76426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-atom dealkylation of caffeine (Rattus norvegicus)
REACT:R-HSA-6814766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDPD1 hydrolyzes LysoPtdCho (Homo sapiens)
RHEA:36837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-HSA-6802943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
GO:0061775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent cohesin loading activity
GO:0061775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cohesin ATPase activity
GO:0061775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cohesin loading activity
GO:0061775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cohesin loader activity
GO:0061775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cohesin loading ATPase
REACT:R-BTA-174097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdh1 (Bos taurus)
REACT:R-DRE-5693566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 associates with H4K20Me2 at DNA DSBs (Danio rerio)
REACT:R-DDI-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Dictyostelium discoideum)
REACT:R-XTR-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Xenopus tropicalis)
RHEA:26112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
REACT:R-XTR-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Xenopus tropicalis)
RHEA:29417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(out) + H(+)(out) => (S)-lactate(in) + H(+)(in)
REACT:R-CFA-351913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of TJP1 (Canis familiaris)
REACT:R-MMU-9661799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)
REACT:R-HSA-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Homo sapiens)
REACT:R-SSC-914182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 zeta binding allows recruitment of PI3K (Sus scrofa)
RHEA:12179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine
RHEA:17201	skos:prefLabel	"2-dehydro-3-deoxy-L-arabinonate dehydratase"
RHEA:17201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O
RHEA:17201	skos:altLabel	"2-keto-3-deoxy-L-arabinonate dehydratase"
RHEA:17201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-L-arabinonate dehydratase"
RHEA:50611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + NADP(+) <=> 12-oxo-leukotriene B4 + H(+) + NADPH
REACT:R-DME-936963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization (Drosophila melanogaster)
RHEA:68232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out)
RHEA:35435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose = cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP
RHEA:35435	skos:prefLabel	"cyanidin 3-O-galactoside 2''-O-xylosyltransferase"
RHEA:35435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanidin 3-O-galactoside 2''-O-xylosyltransferase"
REACT:R-BTA-5244669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Bos taurus)
REACT:R-SSC-5610754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Sus scrofa)
RHEA:26195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl-CoA + ADP + phosphate => (S)-malate + ATP + CoA
RHEA:68661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:40365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP
REACT:R-XTR-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Xenopus tropicalis)
REACT:R-MMU-8864343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD1 binds TFAP2 homo- and heterodimers (Mus musculus)
RHEA:49567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate <=> 2-epi-valiolone + phosphate
REACT:R-DME-9727188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B binds PPIs (Drosophila melanogaster)
RHEA:37916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
RHEA:36199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine
GO:0102339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-arachidoyl-CoA reductase activity
RHEA:57555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Drosophila melanogaster)
REACT:R-CFA-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Canis familiaris)
RHEA:15764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH
REACT:R-CFA-350319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of vimentin at IDVD (259) (Canis familiaris)
REACT:R-MMU-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Mus musculus)
REACT:R-CEL-3209159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERF translocates to the cytosol (Caenorhabditis elegans)
REACT:R-CEL-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Caenorhabditis elegans)
REACT:R-CFA-422021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Canis familiaris)
GO:0004714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	receptor protein-tyrosine kinase activity
GO:0004714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor protein tyrosine kinase activity
GO:0004714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	receptor protein tyrosine kinase activity
RHEA:35345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodocosanoyl-CoA + H(+) + NADPH => 3-hydroxydocosanoyl-CoA + NADP(+)
REACT:R-MMU-446870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated TRAF6 binds the TAK1 complex (Mus musculus)
REACT:R-CEL-428518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glypican-1 (GPC1) binds SLIT2 (Caenorhabditis elegans)
RHEA:16307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methylglutarate + CoA + H(+) => (3S)-hydroxy-3-methylglutaryl-CoA + H2O
REACT:R-BTA-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Bos taurus)
EC:3.2.1.200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exo-chitinase (non-reducing end)"
EC:3.2.1.200	skos:prefLabel	"exo-chitinase (non-reducing end)"
RHEA:69561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(out) + H(+)(out) => D-mannose(in) + H(+)(in)
RHEA:12859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate => (2S,3S)-3-methyl-L-aspartate
RHEA:63212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + methylglyoxal = 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O
REACT:R-SSC-9753285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 monooxygenates APAP to NAPQI (Sus scrofa)
RHEA:39426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O
RHEA:49857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0047723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosinate nucleosidase activity
GO:0047723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-inosinate phosphoribohydrolase activity
RHEA:67574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + alpha-muricholate
RHEA:19819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+)
REACT:R-DME-77586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Drosophila melanogaster)
RHEA:45938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA => 3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA
RHEA:34276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine => 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine
REACT:R-CEL-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Caenorhabditis elegans)
RHEA:69123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-phenylalanine <=> 3-phenylpyruvate + glycine
REACT:R-DRE-202237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP3 to PI(3,4)P2 (Danio rerio)
REACT:R-HSA-9021601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Homo sapiens)
REACT:R-CFA-5654406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Canis familiaris)
REACT:R-XTR-8852019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET bound PI3K generates PIP3 (Xenopus tropicalis)
REACT:R-MMU-3968414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Mus musculus)
RHEA:50157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine
RHEA:43573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-arginine + H2O => 5-guanidino-2-oxopentanoate + AH2 + NH4(+)
RHEA:23179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + CoA <=> acetyl-CoA + AMP + diphosphate
REACT:R-DRE-2309779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer binds PTGS2 inhibitors (Danio rerio)
GO:0015312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyamine:hydrogen antiporter activity
GO:0015312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyamine:proton antiporter activity
REACT:R-BTA-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Bos taurus)
REACT:R-CFA-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Canis familiaris)
REACT:R-GGA-1254386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 forms a complex with estrogen receptor ESR1 (Gallus gallus)
REACT:R-SSC-1433501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other adapter proteins with p-KIT (Sus scrofa)
REACT:R-HSA-8874212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L1 (Homo sapiens)
RHEA:22794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocardicin A => isonocardicin A
REACT:R-CFA-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Canis familiaris)
RHEA:57549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Hg + NADP(+) = Hg(2+) + NADPH
RHEA:23856	skos:prefLabel	"mercury(II) reductase"
RHEA:23856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mercury(II) reductase"
RHEA:23856	skos:altLabel	"mercuric reductase"
REACT:R-CEL-159574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Caenorhabditis elegans)
EC:3.4.24.68	skos:altLabel	"tetanus neurotoxin"
EC:3.4.24.68	skos:prefLabel	"tentoxilysin"
EC:3.4.24.68	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tentoxilysin"
REACT:R-BTA-6798489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A7 or S100A7A binds Zn2+ (Bos taurus)
RHEA:26317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-amino-4-hydroxybenzoate synthase"
RHEA:26317	skos:altLabel	"3,4-AHBA synthase"
RHEA:26317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate
RHEA:26317	skos:prefLabel	"3-amino-4-hydroxybenzoate synthase"
RHEA:62075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose 6-phosphate + NADP(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH
RHEA:70296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-sulfino-L-alanine => 3-sulfinopyruvate + L-glutamate
REACT:R-SSC-9700149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds PLCG1 (Sus scrofa)
REACT:R-HSA-6792491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates CCNG1 gene expression (Homo sapiens)
REACT:R-CFA-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Canis familiaris)
REACT:R-DRE-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Danio rerio)
REACT:R-HSA-6814734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDSN binds the cornified envelope (Homo sapiens)
REACT:R-RNO-5692315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OX40L binds OX40 (Rattus norvegicus)
REACT:R-HSA-8944261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIII (Homo sapiens)
RHEA:40215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 = FAD + H(+) + H2O2
RHEA:71052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(out) + L-methionine(in) => L-leucine(in) + L-methionine(out)
RHEA:61621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose => [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)
REACT:R-HSA-166245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Homo sapiens)
RHEA:36095	skos:altLabel	"salicylate O-methyltransferase"
RHEA:36095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + salicylate = methyl salicylate + S-adenosyl-L-homocysteine
RHEA:36095	skos:prefLabel	"salicylate carboxymethyltransferase"
RHEA:36095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salicylate carboxymethyltransferase"
RHEA:19391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + ADP + phosphate => (E)-ferulate + ATP + CoA
REACT:R-CFA-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Canis familiaris)
REACT:R-DRE-168849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAX protein (Danio rerio)
RHEA:34888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenate(in) => selenate(out)
RHEA:32149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+) => H2O + sepiapterin
REACT:R-SSC-443774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homodimerization of Neurofascin (Sus scrofa)
RHEA:61913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + voriconazole(in) => ADP + H(+) + phosphate + voriconazole(out)
RHEA:53093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-981535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) binds C3bBb, C4bC2a (Bos taurus)
REACT:R-DRE-3204318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Danio rerio)
RHEA:37816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate
REACT:R-SPO-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Schizosaccharomyces pombe)
RHEA:34333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + CO2 + H2O + NADP(+) => H(+) + indole-3-pyruvate + NADPH + O2
REACT:R-MMU-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Mus musculus)
REACT:R-SSC-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Sus scrofa)
REACT:R-SSC-5668731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX3 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)
REACT:R-BTA-204981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3epsilon attentuates NADE-related apoptosis (Bos taurus)
REACT:R-PFA-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Plasmodium falciparum)
REACT:R-CFA-9027272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)
REACT:R-PFA-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Plasmodium falciparum)
REACT:R-DRE-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Danio rerio)
REACT:R-DME-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Drosophila melanogaster)
RHEA:47224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fucose(in) => D-fucose(out)
RHEA:43441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + sphinganine => H2O + N-hexadecanoylsphinganine
RHEA:33897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose
RHEA:34834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate <=> N-acyl-15-methylhexadecasphing-4-enine + phosphate
RHEA:13355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol
GO:0005043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	netrin receptor activity involved in chemorepulsion
GO:0005043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	netrin receptor activity involved in negative chemotaxis
GO:0005043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	repulsive netrin receptor activity
REACT:R-RNO-4224014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by ADAM10, ADAM15 (Rattus norvegicus)
RHEA:18403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-391940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 and EP4 receptors can bind PGE2 (Gallus gallus)
REACT:R-BTA-977301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histidine is decarboxylated to histamine (Bos taurus)
REACT:R-DME-1592371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP3 (Drosophila melanogaster)
REACT:R-DRE-2046096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Danio rerio)
RHEA:21767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5617642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXD3 gene is transcribed (Homo sapiens)
REACT:R-DRE-6786190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMBL hydrolyses OM to OLMS (Danio rerio)
REACT:R-BTA-8983870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Bos taurus)
REACT:R-DME-6805399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAF1 phosphorylates TP53 (Drosophila melanogaster)
RHEA:27828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + succinate => hydrogen sulfide + O-succinyl-L-homoserine
RHEA:65957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + estrone 3-sulfate(out) + H2O => ADP + estrone 3-sulfate(in) + H(+) + phosphate
REACT:R-DME-176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST trimers transfer GS from GSH to luminal substrates (Drosophila melanogaster)
REACT:R-GGA-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Gallus gallus)
RHEA:70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(in) + 2 Na(+)(in) => D-galactose(out) + 2 Na(+)(out)
GO:0004066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine-dependent asparagine synthetase activity
GO:0004066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AS-B activity
GO:0004066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagine synthase (glutamine-hydrolyzing) activity
GO:0004066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine synthetase B activity
GO:0004066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine synthetase (glutamine-hydrolysing)
GO:0004066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine synthase (glutamine-hydrolysing)
GO:0004066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AS
GO:0004066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate:L-glutamine amido-ligase (AMP-forming)
GO:0004066	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine synthetase (glutamine-hydrolyzing) activity
REACT:R-MMU-372480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Mus musculus)
REACT:R-CFA-5684081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds CDK2 and RBBP8 (Canis familiaris)
REACT:R-DME-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Drosophila melanogaster)
REACT:R-MMU-4641129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is ubiquitinated by SMURF2 (Mus musculus)
RHEA:21244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine = an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9612448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MXD4 gene expression is stimulated by ERBB4s80 (Homo sapiens)
RHEA:20360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + H(+) + NADH + O2 <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)
REACT:R-RNO-449077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-16 is secreted (Rattus norvegicus)
RHEA:11452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-442387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP8 mediates zinc influx into cells (Caenorhabditis elegans)
RHEA:21847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + phenylacetyl-CoA <=> CoA + H(+) + N(2)-phenylacetyl-L-glutamine
EC:4.6.1.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease U2"
EC:4.6.1.20	skos:altLabel	"RNase U2"
EC:4.6.1.20	skos:prefLabel	"ribonuclease U2"
RHEA:34138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2
GO:0003921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP synthase activity
RHEA:15393	skos:prefLabel	"diaminopimelate epimerase"
RHEA:15393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diaminopimelate epimerase"
RHEA:15393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate
RHEA:64724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate
REACT:R-DRE-9638097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)
RHEA:53866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+)
REACT:R-DRE-429581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 transports vitamins from extracellular region to cytosol (Danio rerio)
REACT:R-PFA-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Plasmodium falciparum)
RHEA:17140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 <=> thromboxane A2
REACT:R-SPO-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)
GO:0033775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxysarpagine hydroxylase activity
GO:0033775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity
GO:0033775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DOSH
REACT:R-GGA-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Gallus gallus)
REACT:R-CFA-9026780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)
REACT:R-HSA-9673231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX) (Homo sapiens)
REACT:R-CFA-8984012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Canis familiaris)
REACT:R-DME-5675194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPK phosphorylates RAF1 (Drosophila melanogaster)
RHEA:28414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamylputrescine + H2O + O2 = 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)
RHEA:60412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monoglucosyl-enterobactin = [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)
RHEA:11579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine <=> AMP + H(+) + thiamine diphosphate
EC:3.1.4.1	skos:altLabel	"5' nucleotide phosphodiesterase/alkaline phosphodiesterase I"
EC:3.1.4.1	skos:altLabel	"phosphodiesterase"
EC:3.1.4.1	skos:altLabel	"oligonucleate 5'-nucleotidohydrolase"
EC:3.1.4.1	skos:altLabel	"alkaline phosphodiesterase"
EC:3.1.4.1	skos:altLabel	"5'NPDE"
EC:3.1.4.1	skos:altLabel	"orthophosphoric diester phosphohydrolase"
EC:3.1.4.1	skos:altLabel	"PDE I"
EC:3.1.4.1	skos:altLabel	"5'-phosphodiesterase"
EC:3.1.4.1	skos:altLabel	"5'-PDE"
EC:3.1.4.1	skos:altLabel	"5'-exonuclease"
EC:3.1.4.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphodiesterase I"
EC:3.1.4.1	skos:altLabel	"5'-nucleotide phosphodiesterase"
EC:3.1.4.1	skos:altLabel	"5'-PDase"
EC:3.1.4.1	skos:altLabel	"nucleotide pyrophosphatase/phosphodiesterase I"
EC:3.1.4.1	skos:prefLabel	"phosphodiesterase I"
EC:3.1.4.1	skos:altLabel	"5'-NPDase"
EC:3.1.4.1	skos:altLabel	"exonuclease I"
RHEA:48214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O
RHEA:13972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + GTP <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP
REACT:R-SPO-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Schizosaccharomyces pombe)
RHEA:26266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroabietadienal + H2O + NADP(+) => dehydroabietate + 2 H(+) + NADPH
REACT:R-DRE-199203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK1/3/4 phosphorylate PanK (Danio rerio)
REACT:R-XTR-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Xenopus tropicalis)
REACT:R-BTA-77590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CstF to the CPSF Bound Pre-mRNA (Bos taurus)
REACT:R-RNO-9034042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Rattus norvegicus)
RHEA:25148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => H(+) + H2O + quinolinate
RHEA:45626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine
RHEA:50551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E1 <=> H2O + prostaglandin A1
REACT:R-HSA-9605057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA1 gene transcription regulated by NR1H2 or NR1H3 (Homo sapiens)
RHEA:50154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
RHEA:41300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-sphing-4-enine => (9Z)-octadecenoate + sphing-4-enine
REACT:R-GGA-4088218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetrastatin binds integrin alphaVbeta3 (Gallus gallus)
REACT:R-HSA-5625416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anterograde IFT (Homo sapiens)
REACT:R-HSA-8961636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the POLA1 gene promoter (Homo sapiens)
GO:0001853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C3dg binding
REACT:R-CFA-8944214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type I (Canis familiaris)
REACT:R-DDI-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)
RHEA:35136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-L-glutamate(out) => L-alanyl-L-glutamate(in)
REACT:R-DDI-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Dictyostelium discoideum)
REACT:R-CFA-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Canis familiaris)
REACT:R-MMU-2395322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyridinoline cross-links (Mus musculus)
RHEA:13731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + riboflavin cyclic-4',5'-phosphate => FAD
REACT:R-GGA-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Gallus gallus)
GO:0002057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine binding
RHEA:35457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+) => 5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2
GO:0031701	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	angiotensin receptor ligand
GO:0031701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin receptor binding
RHEA:37130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dioxidophosphate + H2O2 <=> CO2 + H(+) + phosphonate + succinate
RHEA:34054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'''-acetyl-6'''-hydroxyneomycin C + H2O <=> 6'''-deamino-6'''-hydroxyneomycin C + acetate
RHEA:22075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-ribulose <=> ADP + H(+) + L-ribulose 5-phosphate
REACT:R-CFA-8853801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPN binds RET:GFRA4 (Canis familiaris)
REACT:R-CFA-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Canis familiaris)
REACT:R-CFA-2429719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCPH1 sequesters condensin II (Canis familiaris)
GO:0004713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-tyrosine kinase activity
GO:0004713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine kinase activity
REACT:R-DRE-5686440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81:EME1,EME2 cleaves D-loop (Danio rerio)
RHEA:49469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP
REACT:R-BTA-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Bos taurus)
REACT:R-MMU-9707594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind LY96 (Mus musculus)
GO:0061787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan cross-bridge peptide endopeptidase activity
GO:0061787	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lysostaphin activity
REACT:R-XTR-110141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Xenopus tropicalis)
REACT:R-RNO-8876837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB21 GEFs exchange GTP for GDP on RAB21 (Rattus norvegicus)
RHEA:25219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetylserotonin => acetyl-CoA + serotonin
REACT:R-HSA-5692408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPR2 binds NPPC (Homo sapiens)
REACT:R-HSA-9685597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTC binds SARS-CoV-1 genomic RNA complement (minus strand) (Homo sapiens)
REACT:R-XTR-2467811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of sister chromatids (Xenopus tropicalis)
REACT:R-MMU-374686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 interaction with Integrins (Mus musculus)
REACT:R-DRE-5632652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds CDON and PTCH (Danio rerio)
REACT:R-XTR-173488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
REACT:R-CFA-6786050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Canis familiaris)
RHEA:47853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate
RHEA:55745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-SSC-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Sus scrofa)
REACT:R-CEL-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Caenorhabditis elegans)
RHEA:22574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + formaldehyde + L-glutamate => A + H2O + N-methyl-L-glutamate
REACT:R-HSA-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Homo sapiens)
REACT:R-CFA-266299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds membrane-associated free cholesterol and phospholipids (Canis familiaris)
GO:0047549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-nitrophenol oxygenase activity
GO:0047549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)
GO:0047549	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nitrophenol oxygenase activity
GO:0047549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrophenol 2-monooxygenase activity
GO:0043715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
GO:0043715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E-1
GO:0043715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DK-MTP-1-P enolase activity
GO:0043715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mtnW
GO:0043715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MasA
REACT:R-HSA-168883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of NS1 to poly(A)-binding protein II (PABII) (Homo sapiens)
RHEA:56803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide <=> cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]
REACT:R-RNO-2685505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPCN1/2 transport lysosomal Ca2+ to cytosol  (Rattus norvegicus)
REACT:R-DME-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Drosophila melanogaster)
REACT:R-HSA-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Homo sapiens)
REACT:R-DRE-1358795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitination of RNF41 by P-USP8 (Danio rerio)
REACT:R-SSC-110349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of UNG glycosylase by APEX1 at the AP site (Sus scrofa)
RHEA:37439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
REACT:R-RNO-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Rattus norvegicus)
RHEA:39645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH
REACT:R-XTR-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Xenopus tropicalis)
REACT:R-MMU-9646685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggresome dissociates from dynein and microtubule (Mus musculus)
RHEA:30038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NAD(+)
RHEA:62200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + 2 Fe(III)-[cytochrome c] = acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-CFA-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Canis familiaris)
EC:1.14.14.32	skos:altLabel	"CYP17A1"
EC:1.14.14.32	skos:altLabel	"CYP17"
EC:1.14.14.32	skos:prefLabel	"17alpha-hydroxyprogesterone deacetylase"
EC:1.14.14.32	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"17alpha-hydroxyprogesterone deacetylase"
EC:1.14.14.32	skos:altLabel	"17alpha-hydroxyprogesterone 17,20-lyase"
EC:1.14.14.32	skos:altLabel	"17alpha-hydroxyprogesterone acetaldehyde-lyase"
RHEA:72168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurohyodeoxycholate(out) => 2 Na(+)(in) + taurohyodeoxycholate(in)
REACT:R-DDI-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Dictyostelium discoideum)
REACT:R-SSC-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Sus scrofa)
RHEA:28991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminate(in) = N-acetylneuraminate(out)
REACT:R-XTR-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Xenopus tropicalis)
RHEA:38423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)
RHEA:48754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + succinate + validamycin B => 2-oxoglutarate + O2 + validamycin A
REACT:R-SSC-451895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RG binds JAK3 (Sus scrofa)
REACT:R-MMU-5685341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex stabilizes RAD51 filament (Mus musculus)
RHEA:33818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate <=> 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)
REACT:R-DDI-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Dictyostelium discoideum)
REACT:R-GGA-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Gallus gallus)
RHEA:51993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menthone + NADPH + O2 <=> 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)
REACT:R-RNO-201595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plakophilin-1 (Rattus norvegicus)
REACT:R-GGA-5696670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD1L is recruited to GG-NER site (Gallus gallus)
REACT:R-MMU-1606839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Steryl sulfatase hydrolyses sulfate from steroid sulfates (Mus musculus)
REACT:R-HSA-9036308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex (Homo sapiens)
REACT:R-HSA-375133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Basigin binds Mannose-carrying cell recognition molecules (Homo sapiens)
REACT:R-MMU-8866542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Mus musculus)
REACT:R-MMU-376851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Mus musculus)
REACT:R-HSA-73729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of SL1 (Homo sapiens)
REACT:R-XTR-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Xenopus tropicalis)
RHEA:40218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 <=> FAD + H(+) + H2O2
RHEA:54987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol <=> a ubiquinone + 2 e(-) + 2 H(+)
REACT:R-RNO-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Rattus norvegicus)
REACT:R-RNO-352136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Rattus norvegicus)
RHEA:12658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-methylacyl-CoA => a (2R)-2-methylacyl-CoA
REACT:R-CEL-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Caenorhabditis elegans)
REACT:R-DRE-400037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi,Go Heterotrimeric G-protein complex dissociates (Danio rerio)
REACT:R-DRE-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Danio rerio)
RHEA:37813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA
REACT:R-GGA-3322431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds TLE (Gallus gallus)
RHEA:60462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)
RHEA:39093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydecanedioyl-CoA => (2E)-decenedioyl-CoA + H2O
REACT:R-HSA-6790029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PTGS2 (Homo sapiens)
REACT:R-RNO-177941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:GAB1 binds to phosphorylated EGFR (Rattus norvegicus)
RHEA:50159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine
REACT:R-HSA-8982645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRKs bind ADRB2:Catecholamine (Homo sapiens)
RHEA:53075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:23093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + hydroxyatrazine => ethylamine + N-isopropylammelide
GO:1990482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid alpha-glucuronosyltransferase activity
GO:1990482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol phosphorylceramide glucuronosyltransferase activity
RHEA:57109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
GO:0052641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:benzoic acid glucosyltransferase activity
GO:0052641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:BA glucosyltransferase activity
GO:0052641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:benzoate glucosyltransferase activity
GO:0052641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoic acid glucosyltransferase activity
GO:0052641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate glucosyltransferase activity
REACT:R-BTA-420173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR1,CRHR2-1 binds CRH,UCN (Bos taurus)
REACT:R-RNO-432897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ILK interacts with beta-1 integrin (Rattus norvegicus)
REACT:R-BTA-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Bos taurus)
REACT:R-MMU-9633044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR binds STRN (Mus musculus)
GO:0004977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melanocortin receptor activity
RHEA:33409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + glycyl-5'-AMP => ATP + glycine + H(+)
RHEA:29021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(out) + H(+)(out) => D-galactose(in) + H(+)(in)
REACT:R-MMU-2314678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS1 (Mus musculus)
REACT:R-HSA-8874218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L4 translocates from the cytosol to the nucleus (Homo sapiens)
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cation/sugar symporter activity
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lactose/glucose efflux transporter activity
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate:proton symporter activity
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sugar transporter
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydrogen:sugar symporter activity
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton:sugar symporter activity
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sugar:hydrogen symporter activity
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogen:sugar transporter activity
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sugar:proton symporter activity
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sugar porter activity
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sugar:hydrogen ion symporter activity
GO:0005351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sugar efflux transmembrane transporter activity
RHEA:68586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-tryptophan(in) + phosphate => ATP + H2O + L-tryptophan(out)
RHEA:44552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O = H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine
REACT:R-HSA-3797196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-1 transcription factor binds IGFBP7 promoter (Homo sapiens)
REACT:R-CFA-5654646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Canis familiaris)
GO:0050593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylcoclaurine 3'-monooxygenase activity
GO:0050593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)
GO:0050593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P450 80B1 activity
GO:0050593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylcoclaurine 3'-hydroxylase activity
GO:0050593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-N-methylcoclaurine 3'-hydroxylase activity
RHEA:32984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol
REACT:R-RNO-870479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) binds to ubiquitinated SMAD4 (Rattus norvegicus)
RHEA:38151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonyl sulfide + H2O = CO2 + H(+) + hydrogen sulfide
RHEA:38151	skos:altLabel	"COS hydrolase"
RHEA:38151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carbonyl sulfide hydrolase"
RHEA:38151	skos:prefLabel	"carbonyl sulfide hydrolase"
RHEA:38151	skos:altLabel	"COSase"
REACT:R-DME-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Drosophila melanogaster)
REACT:R-CFA-6803892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds BAX (Canis familiaris)
GO:0052858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-phosphate:peptidyl-L-lysine N6-acetyltransferase activity
GO:0052858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-lysine acetyltransferase activity
GO:0052858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-phosphate:peptidyl-L-lysine 6-N-acetyltransferase activity
GO:0052858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-lysine N6-acetyltransferase activity
GO:0052858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-lysine N(6)-acetyltransferase activity
GO:0052858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
RHEA:17925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-arabinopyanose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH
RHEA:40698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol <=> 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-XTR-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Xenopus tropicalis)
RHEA:50760	skos:prefLabel	"sulfite dehydrogenase (quinone)"
RHEA:50760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + sulfite = a quinol + sulfate
RHEA:50760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfite dehydrogenase (quinone)"
RHEA:71350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-lysine(out) + 2 Na(+)(out) <=> chloride(in) + L-lysine(in) + 2 Na(+)(in)
RHEA:16121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)
REACT:R-HSA-380042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)
REACT:R-HSA-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Homo sapiens)
REACT:R-MMU-2404137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)
RHEA:14176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-tryptophan <=> 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate
REACT:R-DRE-6804762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 forms homotetramers (Danio rerio)
REACT:R-BTA-1964496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds TRIM32 or TRIM56  (Bos taurus)
RHEA:10866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acetamidomethylene)succinate + NADP(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2
REACT:R-MMU-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Mus musculus)
REACT:R-RNO-2197770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1 (FEEL-1) binds ligands (Rattus norvegicus)
REACT:R-SSC-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)
REACT:R-RNO-5635843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI translocates to the nucleus (Rattus norvegicus)
REACT:R-RNO-8983384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Rattus norvegicus)
RHEA:30325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0009931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent protein serine/threonine kinase activity
REACT:R-CFA-193641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKK-beta is recruited (Canis familiaris)
RHEA:28640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => (-)-gamma-cadinene + diphosphate
RHEA:50662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)propylmaleate + H2O => 3-(3-methylsulfanyl)propylmalate
RHEA:46561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:44665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-MMU-6791109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds PCNA (Mus musculus)
RHEA:55647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] <=> ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate
RHEA:53823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NADP(+) <=> 7-oxolithocholate + H(+) + NADPH
REACT:R-MMU-3149494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC:cob(II)alamin binds MMADHC (Mus musculus)
RHEA:18768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + a sphingomyelin
REACT:R-CFA-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Canis familiaris)
REACT:R-XTR-3788075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by ADAMTS4, ADAMTS5 (Xenopus tropicalis)
REACT:R-BTA-2213239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MHC II alpha beta heterodimer (Bos taurus)
REACT:R-GGA-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Gallus gallus)
RHEA:66053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + L-kynurenine => H2O + kynurenate + L-tryptophan
REACT:R-HSA-399935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)
RHEA:40409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP
RHEA:42909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(1939) in 23S rRNA => 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Canis familiaris)
REACT:R-XTR-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Xenopus tropicalis)
RHEA:67637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-2'-deoxyadenylo-succinate => dZMP + fumarate
RHEA:23679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
REACT:R-HSA-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Homo sapiens)
RHEA:20379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + H(+) + NADPH => androsterone + NADP(+)
REACT:R-BTA-9708557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 binds BACH1:MAFK (Bos taurus)
RHEA:15728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose <=> ascopyrone M + H2O
REACT:R-DME-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Drosophila melanogaster)
REACT:R-GGA-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Gallus gallus)
GO:0062068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroplast photosystem II binding
REACT:R-DRE-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Danio rerio)
REACT:R-DDI-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Dictyostelium discoideum)
GO:1990362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + NAD(+) = butanal + H(+) + NADH
GO:1990362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanol dehydrogenase activity
REACT:R-DRE-2203479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2 (FEEL-2) binds ligands (Danio rerio)
REACT:R-XTR-5624494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 binds p21 RAS:GTP (Xenopus tropicalis)
REACT:R-DRE-9024326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Danio rerio)
REACT:R-MMU-76472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ethylene is oxidized to Ethylene oxide by CYP1A1 (Mus musculus)
REACT:R-DRE-5617816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A  (Danio rerio)
REACT:R-SCE-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Saccharomyces cerevisiae)
REACT:R-RNO-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Rattus norvegicus)
REACT:R-XTR-192137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
RHEA:35284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA => (2E)-octadecenoyl-CoA
GO:0052598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1H-Imidazole-4-ethanamine:oxygen oxidoreductase (deaminating) activity
GO:0052598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine:oxygen oxidoreductase (deaminating) activity
GO:0052598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine oxidase activity
GO:0052598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1H-Imidazole-4-ethanamine oxidase activity
RHEA:21024	skos:prefLabel	"glyoxylate dehydrogenase (acylating)"
RHEA:21024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyoxylate dehydrogenase (acylating)"
RHEA:21024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA
RHEA:63876	skos:prefLabel	"3(1)-hydroxy-L-isoleucine 4-dioxygenase"
RHEA:63876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3(1)-hydroxy-L-isoleucine 4-dioxygenase"
RHEA:63876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 = (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate
RHEA:63876	skos:altLabel	"4'-hydroxy-L-isoleucine 4-dioxygenase"
RHEA:49322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R,6S)-5,6-epoxi-capsanthin => all-trans-violaxanthin
REACT:R-MMU-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Mus musculus)
REACT:R-HSA-3656382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 does not recruit TGFBR1 LBD Mutants (Homo sapiens)
REACT:R-BTA-4420140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Bos taurus)
REACT:R-PFA-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Plasmodium falciparum)
RHEA:18819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + malonyl-CoA => acetyl-CoA + malonate
RHEA:31183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + decanoyl-CoA = 3-oxododecanoyl-CoA + CoA
RHEA:18583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolaldehyde + H2O2 + NH4(+) => ethanolamine + H2O + O2
REACT:R-DRE-9686922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 binds activated RIPK1:RIPK3 (Danio rerio)
REACT:R-MMU-5649711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 incises DNA strand 5' to the AP site (Mus musculus)
RHEA:29110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + ubiquinone-8 <=> NAD(+) + ubiquinol-8
REACT:R-SSC-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Sus scrofa)
RHEA:65763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-77271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Drosophila melanogaster)
REACT:R-RNO-2029273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to p-6Y-SYK (Rattus norvegicus)
RHEA:25094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dCMP = ADP + dCDP
RHEA:17092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phospho-D-gluconate <=> D-glyceraldehyde 3-phosphate + pyruvate
REACT:R-SSC-83656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Sus scrofa)
EC:2.2.1.11	skos:prefLabel	"6-deoxy-5-ketofructose 1-phosphate synthase"
EC:2.2.1.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-deoxy-5-ketofructose 1-phosphate synthase"
EC:2.2.1.11	skos:altLabel	"DKFP synthase"
REACT:R-MMU-5693108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Mus musculus)
RHEA:47495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isodeoxycholate + NAD(+)
RHEA:33411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O = (S)-malyl alpha-D-glucosaminide + acetate
REACT:R-HSA-9018867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 (Homo sapiens)
REACT:R-CEL-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Caenorhabditis elegans)
RHEA:28804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-ascorbate 6-phosphate => 3-dehydro-L-gulonate 6-phosphate
REACT:R-BTA-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Bos taurus)
REACT:R-DRE-2129357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin C-terminal processing (Danio rerio)
REACT:R-DRE-983700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds the activated BCR (Danio rerio)
GO:0046987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity
GO:0046987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity
RHEA:54956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + OPC-6 = AMP + diphosphate + OPC-6-CoA
REACT:R-PFA-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Plasmodium falciparum)
REACT:R-XTR-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Xenopus tropicalis)
REACT:R-HSA-5679101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)
REACT:R-MMU-71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Mus musculus)
REACT:R-RNO-112435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin BC complex (Rattus norvegicus)
REACT:R-HSA-5617815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binds RAB3IP (Homo sapiens)
REACT:R-DDI-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Dictyostelium discoideum)
REACT:R-SCE-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Saccharomyces cerevisiae)
RHEA:29734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-maltose(in) <=> beta-maltose(out)
REACT:R-HSA-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Homo sapiens)
GO:0047160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkyllyso-GP:acetyl-CoA acetyltransferase activity
GO:0047160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylglycerophosphate 2-O-acetyltransferase activity
GO:0047160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity
RHEA:18741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2alpha-hydroxytaxane 2-O-benzoyltransferase"
RHEA:18741	skos:altLabel	"2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase"
RHEA:18741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA
RHEA:18741	skos:prefLabel	"2alpha-hydroxytaxane 2-O-benzoyltransferase"
RHEA:18741	skos:altLabel	"benzoyl-CoA:taxane 2alpha-O-benzoyltransferase"
REACT:R-SSC-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Sus scrofa)
GO:0061791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTPase motor activity
REACT:R-HSA-1483212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is decarboxylated to PE by PISD (Homo sapiens)
REACT:R-RNO-111285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)
RHEA:34200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => bracteatin 6-O-beta-glucoside + H2O
REACT:R-SCE-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Saccharomyces cerevisiae)
RHEA:56977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol + H2O + 2 oxidized [azurin] => 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]
REACT:R-HSA-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)
REACT:R-CFA-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Canis familiaris)
RHEA:20522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate + NAD(+) => acetoacetate + H(+) + NADH
REACT:R-DME-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Drosophila melanogaster)
RHEA:22433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3S)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH
REACT:R-XTR-5687097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3 binds ETV4 (Xenopus tropicalis)
RHEA:13066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O => ADP + H(+) + phosphate
GO:0045296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadherin binding
RHEA:62743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2
RHEA:32736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Gallus gallus)
REACT:R-RNO-4090408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate ESR1 with SUMO1 (Rattus norvegicus)
REACT:R-RNO-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)
REACT:R-BTA-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Bos taurus)
REACT:R-CEL-5638004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 binds ARL3:GTP:UNC119B (Caenorhabditis elegans)
REACT:R-GGA-5686398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPIDR binds BLM:TOP3A:RMI1:RMI2 (Gallus gallus)
REACT:R-BTA-5685156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2 (Bos taurus)
RHEA:24107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA <=> 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine
RHEA:19940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sarcosine
REACT:R-SPO-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Schizosaccharomyces pombe)
REACT:R-SSC-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Sus scrofa)
RHEA:14770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nicotine + A + H2O => (S)-6-hydroxynicotine + AH2
REACT:R-BTA-1475414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Bos taurus)
REACT:R-BTA-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Bos taurus)
RHEA:52721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O => 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)
RHEA:32112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-resveratrol => 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine
GO:0034788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity
RHEA:54684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-kolavenyl diphosphate synthase"
RHEA:54684	skos:altLabel	"CLPP"
RHEA:54684	skos:altLabel	"clerodienyl diphosphate synthase"
RHEA:54684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = (-)-kolavenyl diphosphate
RHEA:54684	skos:prefLabel	"(-)-kolavenyl diphosphate synthase"
REACT:R-XTR-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Xenopus tropicalis)
REACT:R-DME-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Drosophila melanogaster)
REACT:R-DME-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Drosophila melanogaster)
REACT:R-BTA-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Bos taurus)
GO:0035755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer hydrolyses cardiolipin to PA and PG (Homo sapiens)
GO:0035755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cardiolipin hydrolase activity
REACT:R-MMU-264758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Mus musculus)
RHEA:36660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + descarbamoylnovobiocin => novobiocin + phosphate
RHEA:72512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + 2-oxoglutarate(in) => (R)-carnitine(in) + 2-oxoglutarate(out)
REACT:R-CFA-8983061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSLP binds CRLF2:IL7R (Canis familiaris)
RHEA:62871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 <=> H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)
RHEA:35775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + UDP-3-oxo-alpha-D-glucose = 2-oxoglutaramate + UDP-alpha-D-kanosamine
RHEA:27949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + H2O + O2 <=> 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)
EC:1.14.13.105	skos:altLabel	"MMKMO"
EC:1.14.13.105	skos:altLabel	"dihydrocarvone 1,2-monooxygenase"
EC:1.14.13.105	skos:prefLabel	"monocyclic monoterpene ketone monooxygenase"
EC:1.14.13.105	skos:altLabel	"1-hydroxy-2-oxolimonene 1,2-monooxygenase"
EC:1.14.13.105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monocyclic monoterpene ketone monooxygenase"
REACT:R-CEL-8870352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:20679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP => alizarin + UDP-alpha-D-glucose
RHEA:48235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-glutamate 5-semialdehyde <=> CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde
RHEA:61041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)
RHEA:59820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP = adenosine 3'-diphosphate,5'-triphosphate + AMP
REACT:R-HSA-1855162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Homo sapiens)
RHEA:37035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminopentanoate + NAD(+) = 2-oxopentanoate + H(+) + NADH + NH4(+)
REACT:R-HSA-5218814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 autophorylates (Homo sapiens)
RHEA:52477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + UDP-alpha-D-glucuronate => estrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-DRE-114560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adhesion of integrin alphaIIbbeta3 to fibrin network (Danio rerio)
REACT:R-SCE-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Saccharomyces cerevisiae)
REACT:R-BTA-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Bos taurus)
RHEA:48044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)/18:0) + H2O = D-galactose + ganglioside GM2 (d18:1(4E)/18:0)
RHEA:48773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a => 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O
REACT:R-HSA-9035949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective B4GALT1 does not transfer Gal to the N-glycan precursor (Homo sapiens)
REACT:R-CEL-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Caenorhabditis elegans)
REACT:R-CEL-750988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (z) reassociates with G beta:gamma (Caenorhabditis elegans)
RHEA:49896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate = 5,10-dihydrophenazine-1,6-dicarboxylate
EC:3.5.4.18	skos:prefLabel	"ATP deaminase"
EC:3.5.4.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ATP deaminase"
RHEA:42126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)
REACT:R-MMU-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Mus musculus)
REACT:R-GGA-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Gallus gallus)
RHEA:50487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]
REACT:R-RNO-202722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD48 binds CD244 (Rattus norvegicus)
RHEA:61635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanal + H2O + NAD(+) <=> 5-aminopentanoate + 2 H(+) + NADH
REACT:R-BTA-9647680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP1 cleaves GSDMD (Bos taurus)
REACT:R-SSC-1433418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Sus scrofa)
REACT:R-PFA-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Plasmodium falciparum)
REACT:R-HSA-5625015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-XTR-5654730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Xenopus tropicalis)
REACT:R-XTR-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)
REACT:R-CEL-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Caenorhabditis elegans)
REACT:R-DME-6805755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 dimethylates TP53 (Drosophila melanogaster)
RHEA:53624	skos:prefLabel	"tsukubadiene synthase"
RHEA:53624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + tsukubadiene
RHEA:53624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tsukubadiene synthase"
RHEA:25157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
REACT:R-BTA-202325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Gads to LAT (Bos taurus)
REACT:R-MMU-5617829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of IFT A complex (Mus musculus)
GO:0030774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilic acid N-methyltransferase activity
GO:0030774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:anthranilate N-methyltransferase activity
GO:0030774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate N-methyltransferase activity
RHEA:10969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + CoA + GTP => an acyl-CoA + GDP + phosphate
RHEA:63612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D-glucuronide + UDP
RHEA:43513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(dihydroxymethyl)-5-formylfuran + O2 => 2-carboxy-5-formylfuran + H(+) + H2O2
REACT:R-SSC-5675431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates RAF1 (Sus scrofa)
RHEA:50002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + H2O + NAD(+) => butane + H(+) + NADH + O2
REACT:R-RNO-4420083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)
RHEA:19415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe) => ATP + L-phenylalanine + tRNA(Phe)
REACT:R-XTR-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Xenopus tropicalis)
RHEA:50086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out) => ATP + H2O + taurolithocholate 3-sulfate(in)
GO:0102711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A25,oxoglutarate:oxygen oxidoreductase activity
REACT:R-SPO-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Schizosaccharomyces pombe)
REACT:R-BTA-193981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 oxidises 17HPROG (Bos taurus)
REACT:R-GGA-4551604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO1 (Gallus gallus)
REACT:R-CFA-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Canis familiaris)
RHEA:59560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N',N''-triacetylchitotriono-1,5-lactone = H(+) + N,N',N''-triacetylchitotrionate
RHEA:38182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-9609742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Sus scrofa)
REACT:R-GGA-3296233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T2Rs bind bitter-tasting compounds (Gallus gallus)
REACT:R-MMU-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Mus musculus)
REACT:R-CFA-909719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STAT2 to p-IFNAR1 (Canis familiaris)
REACT:R-GGA-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Gallus gallus)
REACT:R-DME-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Drosophila melanogaster)
REACT:R-BTA-5620921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Bos taurus)
REACT:R-HSA-446212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Flipping of the N-glycan precursor to inside the ER (Homo sapiens)
REACT:R-RNO-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Rattus norvegicus)
EC:1.14.14.172	skos:prefLabel	"3,5,6-trichloropyridin-2-ol monooxygenase"
EC:1.14.14.172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,5,6-trichloropyridin-2-ol monooxygenase"
REACT:R-GGA-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Gallus gallus)
REACT:R-CFA-9010681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates ROBO3.1 (Canis familiaris)
REACT:R-HSA-8938158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCQ gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
REACT:R-CFA-9023626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)
RHEA:36991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil
REACT:R-CEL-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)
REACT:R-SSC-388809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTLA-4 binds B7-1/B7-2 (Sus scrofa)
REACT:R-RNO-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Rattus norvegicus)
RHEA:50612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanal + NADP(+) = (2E)-decenal + H(+) + NADPH
GO:0086076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling
GO:0086076	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gap junction channel activity involved in atrial cardiomyocyte-AV node cell electrical coupling
GO:0086076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in atrial cardiomyocyte-atrioventricular node cell electrical coupling
REACT:R-BTA-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Bos taurus)
REACT:R-DME-8871373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMX phosphorylates RUFY1 (Drosophila melanogaster)
REACT:R-SSC-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Sus scrofa)
REACT:R-CFA-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Canis familiaris)
RHEA:41890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoyl-[ACP] + NADP(+) => 3-oxotetradecanoyl-[ACP] + H(+) + NADPH
RHEA:24123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + leukotriene E4 + NADPH + O2 <=> 20-hydroxy-leukotriene E4 + H2O + NADP(+)
REACT:R-HSA-933536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7 dimer interacts with coactivator CBP/p300 (Homo sapiens)
REACT:R-DME-399952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIMK-1 by PAK (Drosophila melanogaster)
REACT:R-BTA-389487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 2 receptor can bind orexin-B neuropeptide (Bos taurus)
RHEA:65918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-alanine => L-kynurenine + pyruvate
REACT:R-SSC-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Sus scrofa)
REACT:R-XTR-209573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Xenopus tropicalis)
REACT:R-GGA-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Gallus gallus)
RHEA:42412	skos:prefLabel	"cyclic 2,3-diphosphoglycerate synthase"
RHEA:42412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + ATP + H(+) = ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate
RHEA:42412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclic 2,3-diphosphoglycerate synthase"
REACT:R-CEL-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Caenorhabditis elegans)
REACT:R-BTA-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Bos taurus)
RHEA:39587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)
RHEA:36146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + H(+) + NADPH <=> hexadecanoyl-CoA + NADP(+)
RHEA:44842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-octadecanoyl-(R)-carnitine => (R)-carnitine + octadecanoyl-CoA
RHEA:42259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanoyl-CoA + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + CoA
RHEA:69416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + thiocyanate = H2O + hypothiocyanous acid
RHEA:63710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-XTR-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Xenopus tropicalis)
REACT:R-MMU-1475028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Mus musculus)
RHEA:46884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
REACT:R-HSA-9681596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3CLp dimer binds α-Ketoamides (Homo sapiens)
REACT:R-CFA-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Canis familiaris)
REACT:R-RNO-193656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with RIP2 (Rattus norvegicus)
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFATc4 binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFATx binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear factor of activated T cell protein binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFATc binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFAT binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFAT3 protein binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFAT4 protein binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFAT5 protein binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFATc3 binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFAT1 protein binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFATc2 binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFAT protein binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFATp binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	non-calcium-regulated NFAT protein binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFATc1 binding
GO:0051525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NFAT2 protein binding
REACT:R-MMU-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Mus musculus)
RHEA:65151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phloretin + UDP-alpha-D-glucose <=> H(+) + trilobatin + UDP
RHEA:10611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:7.2.1.-	skos:prefLabel	"Linked to oxidoreductase reactions"
EC:7.2.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Linked to oxidoreductase reactions"
REACT:R-CFA-6786155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLN binds ICL-DNA (Canis familiaris)
REACT:R-SSC-8873834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 transports PC from ER membrane to lamellar body membrane (Sus scrofa)
RHEA:30232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine => (2E,6E)-farnesal + H2O2 + L-cysteine
RHEA:61831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stigmasterol + UDP-alpha-D-glucose <=> H(+) + stigmasteryl 3-beta-D-glucoside + UDP
RHEA:70169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in)
REACT:R-RNO-1250380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Rattus norvegicus)
REACT:R-MMU-5357831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD is phosphorylated by IKK (Mus musculus)
EC:1.18.99.-	skos:prefLabel	"With H(+) as acceptor"
EC:1.18.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With H(+) as acceptor"
REACT:R-RNO-5656105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Rattus norvegicus)
REACT:R-RNO-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Rattus norvegicus)
RHEA:54920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH
RHEA:45499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]
RHEA:38102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + phytyl phosphate <=> a ribonucleoside 5'-diphosphate + phytyl diphosphate
REACT:R-HSA-9012650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)
REACT:R-GGA-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Gallus gallus)
RHEA:67718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein] => NADPH + 2 oxidized [2Fe-2S]-[protein]
RHEA:61159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + GTP <=> CoA + GDP + H(+)
RHEA:26377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP = cyclic pyranopterin phosphate + diphosphate
REACT:R-BTA-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Bos taurus)
REACT:R-RNO-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Rattus norvegicus)
RHEA:35653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+) => (4R)-hydroxysphinganine + a fatty acyl-CoA
REACT:R-SSC-2309773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS2 (Sus scrofa)
GO:0047985	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	bidirectional hydrogenase activity
GO:0047985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:NAD+ oxidoreductase activity
GO:0047985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H(2):NAD(+) oxidoreductase activity
GO:0047985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H2:NAD+ oxidoreductase activity
GO:0047985	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogenase activity
GO:0047985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen dehydrogenase activity
GO:0047985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked hydrogenase activity
REACT:R-SSC-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Sus scrofa)
REACT:R-CFA-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Canis familiaris)
REACT:R-SSC-9707594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind LY96 (Sus scrofa)
REACT:R-DRE-9623384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-agonists bind ADRA1A,B,D (Danio rerio)
REACT:R-CEL-1504213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Caenorhabditis elegans)
RHEA:25652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,5R)-isopulegone + NADP(+) <=> (6R)-isopiperitenone + H(+) + NADPH
REACT:R-CFA-399712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Canis familiaris)
RHEA:38748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate
REACT:R-CEL-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Caenorhabditis elegans)
REACT:R-SSC-5651739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Sus scrofa)
REACT:R-HSA-9639567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 gene transcription is repressed by KCNIP3 (Homo sapiens)
RHEA:21715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-3-phenylserine <=> benzaldehyde + glycine
REACT:R-SSC-6809006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Sus scrofa)
REACT:R-HSA-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Homo sapiens)
RHEA:17036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> biphenyl-2,3-diol + H(+) + NADH
REACT:R-BTA-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Bos taurus)
REACT:R-MMU-9621179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cinaciguat binds sGC:NO (Mus musculus)
REACT:R-CEL-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)
REACT:R-GGA-451506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR21homodimer binds to DNA (Gallus gallus)
RHEA:11013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophanamide => L-tryptophan + NH4(+)
REACT:R-HSA-9753916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPQI binds proteins in hepatocytes (Homo sapiens)
RHEA:27335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxypyridine + CO2 + H2O + NAD(+) => 6-hydroxynicotinate + 2 H(+) + NADH + O2
RHEA:55727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)
REACT:R-MMU-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Mus musculus)
GO:0050354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate + H(+)
GO:0050354	skos:prefLabel	"triokinase"
GO:0050354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"triokinase"
GO:0050354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-glyceraldehyde 3-phosphotransferase activity
GO:0050354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triose kinase activity
GO:0050354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trio triose kinase (phosphorylating)
GO:0050354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-triokinase activity
GO:0050354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triokinase activity
GO:0050354	skos:altLabel	"triose kinase"
REACT:R-HSA-1236949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of antigenic peptides back to phagosomes via TAP (Homo sapiens)
REACT:R-CEL-4093327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHA binds TIAM1 (Caenorhabditis elegans)
REACT:R-HSA-9706354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of FLT3 (Homo sapiens)
GO:0043531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-diphosphate binding
GO:0043531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine diphosphate binding
GO:0043531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP binding
RHEA:43550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O
REACT:R-DRE-2162226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Danio rerio)
REACT:R-BTA-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Bos taurus)
REACT:R-GGA-8950724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Gallus gallus)
RHEA:58155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + phosphonoacetaldehyde <=> 2 H(+) + NADH + phosphonoacetate
RHEA:11206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin
GO:0031750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D3 dopamine receptor binding
GO:0031750	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D3 dopamine receptor ligand
RHEA:36479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA
REACT:R-RNO-9703895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds CASR agonists (Rattus norvegicus)
REACT:R-HSA-8868666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5:p25 phosphorylates JUN (Homo sapiens)
RHEA:61779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside D + UDP-alpha-D-glucose <=> H(+) + rebaudioside M + UDP
RHEA:44729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)
RHEA:38207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0051371	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-actinin 2 binding
GO:0051371	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-actinin 3 binding
GO:0051371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	muscle alpha-actinin binding
RHEA:18869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-xylulokinase"
RHEA:18869	skos:prefLabel	"L-xylulokinase"
RHEA:18869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-xylulose = ADP + H(+) + L-xylulose 5-phosphate
RHEA:18869	skos:altLabel	"L-xylulose kinase"
RHEA:68933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + octanoate => AMP + diphosphate + NADP(+) + octanal
GO:0090564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-glucose phosphotransferase system transporter activity
REACT:R-CEL-1474158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCHFR binds to GCH1 and negatively regulates its activity (Caenorhabditis elegans)
RHEA:16541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-violaxanthin + O2 = (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin
RHEA:58136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + H(+) = acetyl-AMP + diphosphate
REACT:R-DRE-201639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of GAS2 (Danio rerio)
REACT:R-DME-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Drosophila melanogaster)
REACT:R-SSC-5357860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Sus scrofa)
REACT:R-CFA-6786096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)
REACT:R-CEL-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)
REACT:R-SCE-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-CFA-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Canis familiaris)
RHEA:28308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose
RHEA:21271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-canadine + 2 NADP(+) <=> berberine + H(+) + 2 NADPH
REACT:R-CEL-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Caenorhabditis elegans)
GO:1903878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-deoxycorticosterone binding
REACT:R-CFA-8874979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD3 binds GOLGB1 (Canis familiaris)
GO:0047845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxylimonate A-ring-lactonase activity
GO:0047845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxylimonate A-ring-lactonohydrolase activity
REACT:R-MMU-6785178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Mus musculus)
REACT:R-SSC-211178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO1A is excluded from the nucleus (Sus scrofa)
REACT:R-BTA-2230938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin:Haptoglobin:CD163 is endocytosed (Bos taurus)
GO:0160039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serotonin-gated chloride channel activity
REACT:R-RNO-5671763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates PPP1R14A (Rattus norvegicus)
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	keto-valine-ferredoxin oxidoreductase activity
GO:0043807	skos:prefLabel	"3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)"
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)
GO:0043807	skos:altLabel	"VOR"
GO:0043807	skos:altLabel	"ketoisovalerate ferredoxin reductase"
GO:0043807	skos:altLabel	"ketoisovalerate oxidoreductase"
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain oxo acid ferredoxin reductase activity
GO:0043807	skos:altLabel	"branched-chain oxo acid ferredoxin reductase"
GO:0043807	skos:altLabel	"2-oxoisovalerate ferredoxin reductase"
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoisovalerate ferredoxin reductase activity
GO:0043807	skos:altLabel	"keto-valine-ferredoxin oxidoreductase"
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ketoisovalerate ferredoxin reductase activity
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	VOR
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity
GO:0043807	skos:altLabel	"branched-chain ketoacid ferredoxin reductase"
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketoisovalerate ferredoxin reductase activity
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyl-2-oxobutanoate synthase (ferredoxin) activity
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)"
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketoisovalerate oxidoreductase activity
GO:0043807	skos:altLabel	"3-methyl-2-oxobutanoate synthase (ferredoxin)"
GO:0043807	skos:altLabel	"2-ketoisovalerate ferredoxin reductase"
GO:0043807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain ketoacid ferredoxin reductase activity
REACT:R-MMU-2161768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXA4 is converted to EXC4 by LTC4S (Mus musculus)
REACT:R-DRE-349426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MDM4 by CHEK2 (Danio rerio)
RHEA:36625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine => 3-phenylpyruvate + S-adenosyl-L-methionine
RHEA:67013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate
REACT:R-SCE-1482571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)
REACT:R-MMU-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Mus musculus)
RHEA:15678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanamide + H2O => 5-aminopentanoate + NH4(+)
REACT:R-CEL-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Caenorhabditis elegans)
GO:0018817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-hepta-3-ene-1,7-dioate hydratase activity
GO:0018817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-hept-3-ene-1,7-dioate hydratase activity
GO:0018817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HpaH
GO:0018817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity
GO:0015128	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-idonate/D-gluconate:hydrogen symporter activity
GO:0015128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gluconate transmembrane transporter activity
EC:4.2.2.20	skos:altLabel	"chondroitinase"
EC:4.2.2.20	skos:prefLabel	"chondroitin-sulfate-ABC endolyase"
EC:4.2.2.20	skos:altLabel	"chondroitin sulfate ABC endoeliminase"
EC:4.2.2.20	skos:altLabel	"ChS ABC lyase I"
EC:4.2.2.20	skos:altLabel	"chondroitin sulfate ABC endolyase"
EC:4.2.2.20	skos:altLabel	"chondroitin ABC eliminase"
EC:4.2.2.20	skos:altLabel	"ChS ABC lyase"
EC:4.2.2.20	skos:altLabel	"chondroitin ABC lyase"
EC:4.2.2.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chondroitin-sulfate-ABC endolyase"
EC:4.2.2.20	skos:altLabel	"chondroitinase ABC"
EC:4.2.2.20	skos:altLabel	"chondroitin sulfate ABC lyase"
RHEA:41195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)
REACT:R-DRE-934559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is phosphorylated by phosphorylated MNK1 (Danio rerio)
RHEA:34048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'''-deamino-6'''-hydroxyneomycin C + O2 => 6'''-deamino-6'''-oxoneomycin C + H2O2
REACT:R-DRE-2684507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2, 4, (3) bind FGF2 (Danio rerio)
REACT:R-BTA-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Bos taurus)
GO:0016731	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0016731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
GO:0016731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor
REACT:R-BTA-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Bos taurus)
RHEA:71558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-C(alpha)-glycyl-dTMP in DNA + H(+) <=> 5-aminoethyl-dUMP in DNA + CO2
RHEA:58347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->3)-O-lithocholate + H2O <=> D-glucose + lithocholate
GO:0033927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-D-glucan maltohexaohydrolase activity
GO:0033927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-maltohexaohydrolase activity
GO:0033927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan 1,4-alpha-maltohexaosidase activity
GO:0033927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	G6-amylase activity
GO:0033927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltohexaose-producing amylase activity
RHEA:45301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine + H2O => an N-acyl-sphingoid base + H(+) + phosphocholine
REACT:R-PFA-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)
RHEA:19526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (1S,8aR)-delta-cadinene + diphosphate
RHEA:44095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + nonadecanoate <=> AMP + diphosphate + nonadecanoyl-CoA
REACT:R-MMU-5686073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-3Y-SHC1 (Mus musculus)
REACT:R-DRE-8964599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Danio rerio)
REACT:R-HSA-211193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization  of DFF40 (Homo sapiens)
RHEA:43604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)"
RHEA:43604	skos:prefLabel	"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)"
RHEA:43604	skos:altLabel	"4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase"
RHEA:43604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]
RHEA:43604	skos:altLabel	"(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase"
REACT:R-HSA-6803047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCD peptide binds bacterial membrane phospholipids (Homo sapiens)
REACT:R-HSA-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Homo sapiens)
REACT:R-CFA-5668481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
RHEA:33020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3,6-diaminohexanoate + acetyl-CoA => (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)
REACT:R-CEL-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Caenorhabditis elegans)
REACT:R-CEL-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Caenorhabditis elegans)
RHEA:46188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic nitrile + 2 H2O = a carboxylate + NH4(+)
RHEA:46188	skos:prefLabel	"aliphatic nitrilase"
RHEA:46188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aliphatic nitrilase"
REACT:R-HSA-5662596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1F binds cadmium (Homo sapiens)
REACT:R-GGA-8943007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Gallus gallus)
RHEA:48404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aryl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]
REACT:R-HSA-6784204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind OSMR (Homo sapiens)
REACT:R-CFA-70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine => urocanate + NH4+ (Canis familiaris)
REACT:R-RNO-114542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1,RAC2,RHOG activate PI3K (Rattus norvegicus)
RHEA:53898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate
REACT:R-XTR-8853800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARTN binds RET:GFRA1,GFRA3 (Xenopus tropicalis)
REACT:R-DRE-9757951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP8 cleaves N4BP1 at D424, D490 (Danio rerio)
RHEA:29695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(I)inamide(in) = cob(I)inamide(out)
RHEA:14300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-galactose
REACT:R-RNO-429415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
RHEA:30342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-tryptophan <=> CO2 + tryptamine
REACT:R-CFA-5635741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Canis familiaris)
REACT:R-HSA-176517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to PREG (Homo sapiens)
RHEA:65027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) <=> dehydrocholate + H(+) + NADPH
REACT:R-DME-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Drosophila melanogaster)
REACT:R-CFA-2752115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds CD44 (Canis familiaris)
RHEA:26101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-homocitrate = cis-homoaconitate + H2O
REACT:R-MMU-1602417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Mus musculus)
REACT:R-HSA-216050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)
RHEA:57256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP = GTP + H(+) + lactate
RHEA:54036	skos:prefLabel	"mycoredoxin"
RHEA:54036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) = [mycoredoxin]-S-mycothiol-L-cysteine + arsenite
RHEA:54036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycoredoxin"
REACT:R-MMU-5684275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
RHEA:64110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine
REACT:R-BTA-448661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Bos taurus)
REACT:R-XTR-432143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM-1 binds PP2A (Xenopus tropicalis)
RHEA:10764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate
REACT:R-MMU-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Mus musculus)
REACT:R-BTA-5687640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Bos taurus)
REACT:R-CFA-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Canis familiaris)
RHEA:44749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(beta-D-ribosyl)imidazole + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)
REACT:R-CEL-9626928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP binds FOXO1 (Caenorhabditis elegans)
RHEA:68909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + picolinate => AMP + diphosphate + NADP(+) + picolinal
REACT:R-DRE-389532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A binds CTLA4 dimer (Danio rerio)
REACT:R-XTR-2453855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Xenopus tropicalis)
RHEA:27499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => 3'-O-methyltricetin + S-adenosyl-L-methionine
RHEA:33920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + lanosterol + NADPH => 24,25-dihydrolanosterol + NADP(+)
RHEA:63790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine
RHEA:68216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA
RHEA:19466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 nitric oxide + 2 O2 => H(+) + NADP(+) + 2 nitrate
REACT:R-BTA-9749609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCHE hydrolyzes ASA- (Bos taurus)
REACT:R-MMU-9619376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK1 binds calmodulin (Mus musculus)
RHEA:67578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine => [protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O
REACT:R-DRE-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Danio rerio)
REACT:R-DME-8951966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates RUNX3 (Drosophila melanogaster)
REACT:R-HSA-9694524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp13 binds nsp12 (Homo sapiens)
REACT:R-DDI-194718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Dictyostelium discoideum)
RHEA:64579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + NADPH <=> 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)
REACT:R-BTA-418170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB1 binds MAPKs, SRC-1 (Bos taurus)
REACT:R-CEL-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Caenorhabditis elegans)
REACT:R-MMU-190413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2c (Mus musculus)
REACT:R-CFA-9033959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Canis familiaris)
REACT:R-DRE-5226964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKH transports PPi from cytosol to extracellular region (Danio rerio)
REACT:R-MMU-417890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y5 receptor can bind to LPA (Mus musculus)
RHEA:71806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(out) + H(+)(out) <=> acetate(in) + H(+)(in)
RHEA:42030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxolithocholate + H(+) + NADH => NAD(+) + ursodeoxycholate
RHEA:60345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
REACT:R-SSC-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Sus scrofa)
REACT:R-SSC-170672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Sus scrofa)
REACT:R-GGA-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Gallus gallus)
REACT:R-CFA-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)
GO:0010436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carotenoid-cleaving dioxygenase
GO:0010436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carotenoid dioxygenase activity
REACT:R-SCE-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
REACT:R-MMU-9024872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 17(S)-Hp-DHA to PDX (Mus musculus)
RHEA:23039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 inosine + O2 <=> 2 5'-dehydroinosine + 2 H2O
REACT:R-MMU-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Mus musculus)
REACT:R-SSC-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Sus scrofa)
REACT:R-MMU-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Mus musculus)
REACT:R-CEL-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Caenorhabditis elegans)
REACT:R-CEL-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Caenorhabditis elegans)
REACT:R-HSA-373748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD72 (Homo sapiens)
RHEA:17991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[protein] => ATP + L-seryl-[protein]
RHEA:68931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + heptanoate + NADPH <=> AMP + diphosphate + heptanal + NADP(+)
RHEA:67440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(alpha)-acetyl-L-methionine = acetate + L-methionine
GO:0015140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dicarboxylate (succinate/fumarate/malate) antiporter activity
GO:0015140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate transmembrane transporter activity
REACT:R-RNO-8875576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK,CRKL recruits RAC1 GEF to activated MET (Rattus norvegicus)
RHEA:18425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-quinate + NADP(+) = 3-dehydroquinate + H(+) + NADPH
REACT:R-BTA-420580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:PVRL3 trans heterodimer formation (Bos taurus)
REACT:R-CEL-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Caenorhabditis elegans)
RHEA:65981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hnu + previtamin D3 => tachysterol 3
REACT:R-XTR-5340226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB dioxygenates NO (Xenopus tropicalis)
REACT:R-HSA-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Homo sapiens)
RHEA:50189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine
RHEA:20835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanine(out) + H2O <=> ADP + guanine(in) + H(+) + phosphate
REACT:R-DRE-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Danio rerio)
REACT:R-BTA-200410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Bos taurus)
REACT:R-DRE-9793988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates CFLAR at K351, K353 (Danio rerio)
REACT:R-HSA-176942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiple proteins are localized at replication fork (Homo sapiens)
GO:0016483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan hydroxylase activator activity
REACT:R-HSA-169847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of NA tetramers (Homo sapiens)
RHEA:21068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + nitrite = AH2 + nitrate
REACT:R-RNO-5694445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH1 binds TFGA and AREG precursors (Rattus norvegicus)
RHEA:48348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in RNA = a pseudouridine in RNA
REACT:R-GGA-997326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Gallus gallus)
REACT:R-GGA-5665761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL3 binds RHOC:GTP (Gallus gallus)
REACT:R-CEL-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Caenorhabditis elegans)
REACT:R-GGA-8876446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ULK1 phosphorylates DENND3 (Gallus gallus)
RHEA:65006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + decanoyl-[ACP] + diphosphate => ATP + decanoate + holo-[ACP]
REACT:R-DRE-3782637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC8 deacetylates histones (Danio rerio)
REACT:R-CFA-5671993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT-3 binds DLG4 (Canis familiaris)
REACT:R-XTR-430158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds VAV (Xenopus tropicalis)
RHEA:29568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(in) + H(+)(out) => 2 chloride(out) + H(+)(in)
RHEA:41860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O
RHEA:45295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin G2 + AH2 <=> 2-glyceryl-prostaglandin H2 + A + H2O
REACT:R-SSC-6788385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of ATR and ATRIP is recruited to ICL-DNA (Sus scrofa)
REACT:R-BTA-983696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Immunoglobulin of the BCR binds antigen (Bos taurus)
REACT:R-SCE-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Saccharomyces cerevisiae)
REACT:R-CFA-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Canis familiaris)
REACT:R-HSA-429694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 dissociates from the endoplasmic reticulum (Homo sapiens)
RHEA:23191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADH
GO:0061770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation elongation factor binding
RHEA:47837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[5-(aminomethyl)-3-furyl]methyl phosphate + ATP => [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP
RHEA:24463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] <=> acetyl-[ACP] + CO2
REACT:R-CFA-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Canis familiaris)
RHEA:14044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-vicianin + H2O <=> mandelonitrile + vicianose
REACT:R-DDI-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Dictyostelium discoideum)
RHEA:39714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) <=> 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-HSA-164943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nef mediated activation of the T-cell receptor (Homo sapiens)
REACT:R-HSA-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Homo sapiens)
RHEA:32728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain acyl-CoA + H(+) + malonyl-CoA => a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
REACT:R-PFA-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Plasmodium falciparum)
RHEA:41987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propan-2-ol <=> acetone + H(+) + NADH
RHEA:23362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP => L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose
REACT:R-CFA-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)
REACT:R-DME-538904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PER binds to CLK (Drosophila melanogaster)
REACT:R-SSC-373724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds NCK (Sus scrofa)
GO:0033896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease IX activity
GO:0033896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(U)- and poly(C)-specific endoribonuclease activity
REACT:R-SPO-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Schizosaccharomyces pombe)
RHEA:43859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)
REACT:R-HSA-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Homo sapiens)
REACT:R-CFA-8855375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dissociates from CSK (Canis familiaris)
REACT:R-HSA-8937869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter (Homo sapiens)
REACT:R-DDI-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Dictyostelium discoideum)
REACT:R-SCE-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Saccharomyces cerevisiae)
RHEA:50660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O
RHEA:15245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacylglycerol + H2O = a fatty acid + glycerol + H(+)
RHEA:15676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + H2O <=> acetoacetate + CoA + H(+)
REACT:R-HSA-560498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Lipoprotein lipase (LPL) (Homo sapiens)
REACT:R-RNO-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)
RHEA:28541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A
REACT:R-CFA-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Canis familiaris)
REACT:R-MMU-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Mus musculus)
REACT:R-RNO-167429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex  binds GTP (Rattus norvegicus)
REACT:R-CFA-109538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Canis familiaris)
REACT:R-GGA-8864125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Gallus gallus)
RHEA:20279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetoxyarylamine + CoA => acetyl-CoA + an N-hydroxyarylamine
REACT:R-HSA-6802935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
REACT:R-HSA-5625738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Homo sapiens)
RHEA:24040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]
RHEA:25011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-6797653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMGDH:FAD oxidatively demethylates DMGLY to SARC (Mus musculus)
GO:0034785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylate 5-hydroxylase activity
RHEA:37222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-valine + H2O <=> 3-methyl-2-oxobutanoate + AH2 + NH4(+)
REACT:R-RNO-416698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA5A binds to PLXNB3 (Rattus norvegicus)
RHEA:23116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + CoA = 4-hydroxybenzoyl-CoA + AMP + diphosphate
RHEA:23116	skos:altLabel	"4-hydroxybenzoyl-CoA ligase"
RHEA:23116	skos:prefLabel	"4-hydroxybenzoate--CoA ligase"
RHEA:23116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoate--CoA ligase"
RHEA:23116	skos:altLabel	"4-hydroxybenzoate-CoA synthetase"
RHEA:66867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + quiannulatene
REACT:R-DDI-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Dictyostelium discoideum)
REACT:R-BTA-392195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi activation by P2Y purinoceptor 12 (Bos taurus)
REACT:R-DDI-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Dictyostelium discoideum)
REACT:R-BTA-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Bos taurus)
REACT:R-SSC-8954468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Sus scrofa)
REACT:R-GGA-8874849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBRF binds CREB3 (Gallus gallus)
RHEA:55393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in mRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-141422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 converted  to an inhibitory state via interaction with Mad1 (Rattus norvegicus)
RHEA:44440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,3-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol
REACT:R-GGA-8987270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Gallus gallus)
GO:0033550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine-specific MAP kinase phosphatase activity
GO:0033550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP kinase tyrosine phosphatase activity
REACT:R-HSA-8875077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A3 ligates CoA-SH to VLCFA (Homo sapiens)
REACT:R-HSA-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Homo sapiens)
RHEA:12486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside + phosphate => a ribonucleoside 5'-phosphate + H2O
REACT:R-CFA-186826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to the active receptor (Canis familiaris)
REACT:R-HSA-70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Homo sapiens)
REACT:R-GGA-159050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Gallus gallus)
RHEA:20246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin => 3''-O-adenylylstreptomycin + diphosphate
RHEA:20576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]
REACT:R-CFA-349657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)
RHEA:27423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,6E)-alpha-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-SCE-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Saccharomyces cerevisiae)
RHEA:15190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c553] + formate => CO2 + 2 Fe(II)-[cytochrome c553] + H(+)
REACT:R-RNO-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Rattus norvegicus)
REACT:R-BTA-3229181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALM1:Ca2+ binds CNG channel (Bos taurus)
REACT:R-CFA-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Canis familiaris)
REACT:R-SSC-264435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the COP1-p53 complex (Sus scrofa)
GO:0103043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity
REACT:R-CFA-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Canis familiaris)
RHEA:44166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + D-ribose 5-triphosphate => ATP + H2O
REACT:R-DDI-1169397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ISG15 by UBA7 E1 ligase (Dictyostelium discoideum)
REACT:R-MMU-5649681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL2 cleaves 5-OHU from damaged DNA (Mus musculus)
RHEA:71090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) <=> 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)
REACT:R-XTR-212352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ARC coactivator complex (Xenopus tropicalis)
RHEA:28699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mn(2+)(in) = Mn(2+)(out)
REACT:R-HSA-453104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
REACT:R-HSA-9749350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
RHEA:64817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate(in) => 5-aminolevulinate(out)
RHEA:71357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in) => 5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out)
REACT:R-BTA-5668467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTNFR2 binds TNFA trimer:TNFR2 (Bos taurus)
RHEA:46220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,17beta-diol + NAD(+) = 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH
RHEA:71384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(in) + Na(+)(in) => L-asparagine(out) + Na(+)(out)
REACT:R-HSA-202203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PI3K to plasma membrane (Homo sapiens)
RHEA:32763	skos:altLabel	"3-methylornithine--L-lysine ligase"
RHEA:32763	skos:prefLabel	"3-methyl-D-ornithine--L-lysine ligase"
RHEA:32763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-methyl-D-ornithine + ATP + L-lysine = (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate
RHEA:32763	skos:altLabel	"N(6)-[(2R,3R)-3-methylornithyl]-L-lysine synthase"
RHEA:32763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-methyl-D-ornithine--L-lysine ligase"
REACT:R-MMU-5691507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPA deacetylates NAA to acetate and L-aspartate (Mus musculus)
REACT:R-SCE-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)
REACT:R-GGA-9710353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds cardiolipin (Gallus gallus)
REACT:R-CEL-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Caenorhabditis elegans)
REACT:R-DME-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)
REACT:R-HSA-9604767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)
EC:1.14.13.246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4beta-methylsterol monooxygenase"
EC:1.14.13.246	skos:prefLabel	"4beta-methylsterol monooxygenase"
RHEA:45464	skos:altLabel	"acyl-CoA Delta(5)-desaturase"
RHEA:45464	skos:prefLabel	"icosanoyl-CoA 5-desaturase"
RHEA:45464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"icosanoyl-CoA 5-desaturase"
RHEA:45464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DDI-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Dictyostelium discoideum)
REACT:R-HSA-9629499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves thymine glycol (Homo sapiens)
REACT:R-MMU-389348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by pVav1 (Mus musculus)
REACT:R-CEL-173545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Caenorhabditis elegans)
REACT:R-SSC-5687101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 phosphorylates FOXO3 (Sus scrofa)
GO:0047479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trypanothione synthase activity
GO:0047479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TSR synthetase activity
GO:0047479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathionylspermidine:glutathione ligase (ADP-forming)
REACT:R-DDI-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Dictyostelium discoideum)
REACT:R-DDI-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)
REACT:R-HSA-4084978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Homo sapiens)
REACT:R-HSA-1793186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Homo sapiens)
RHEA:19583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	discadenine + H(+) + S-methyl-5'-thioadenosine => N(6)-dimethylallyladenine + S-adenosyl-L-methionine
REACT:R-XTR-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)
RHEA:43184	skos:prefLabel	"25S rRNA (uracil(2843)-N(3))-methyltransferase"
RHEA:43184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"25S rRNA (uracil(2843)-N(3))-methyltransferase"
RHEA:43184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2843) in 25S rRNA = H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine
RHEA:13699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-ribose 5-phosphate + H(+) => ATP + D-ribose
REACT:R-HSA-5625210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT (Homo sapiens)
REACT:R-RNO-994140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Rattus norvegicus)
REACT:R-CFA-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Canis familiaris)
REACT:R-BTA-201475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with R-Smad1/5/8 for type I receptor (Bos taurus)
REACT:R-SSC-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Sus scrofa)
GO:0004382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-diphosphatase activity
GO:0004382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP phosphatase activity
GO:0004382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine-diphosphatase activity
GO:0004382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP diphosphatase activity
GO:0004382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP phosphohydrolase activity
GO:0004382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H2O = GMP + H(+) + phosphate
GO:0004382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine diphosphatase activity
GO:0004382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPase activity
RHEA:14522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + NADP(+) => (2E)-geranial + H(+) + NADPH
REACT:R-RNO-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Rattus norvegicus)
REACT:R-CFA-8957265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades TP73 polyubiquitinated by ITCH (Canis familiaris)
REACT:R-DRE-2046222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Danio rerio)
REACT:R-GGA-975147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Gallus gallus)
RHEA:63997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)
REACT:R-CEL-9660192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR agonists bind VDR (Caenorhabditis elegans)
REACT:R-SCE-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Saccharomyces cerevisiae)
RHEA:11294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + rifamycin O => 2 H(+) + O2 + rifamycin B
RHEA:55533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-phenylalanine + O2 => 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)
RHEA:55822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine
RHEA:10049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanethiol + O-acetyl-L-homoserine => acetate + H(+) + L-methionine
REACT:R-HSA-6800250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates BCL6 expression (Homo sapiens)
RHEA:49467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxybenzoate + H(+) <=> CO2 + resorcinol
RHEA:28903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(in) + H(+)(in) = D-alanine(out) + H(+)(out)
RHEA:11592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]
RHEA:11592	skos:prefLabel	"dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase"
RHEA:11592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase"
REACT:R-CEL-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)
RHEA:60911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in tRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:63430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glucose 6-phosphate + H(+) => ATP + H2O + levoglucosan
REACT:R-SCE-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Saccharomyces cerevisiae)
REACT:R-HSA-9677579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Homo sapiens)
REACT:R-SSC-211951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1B1 4-hydroxylates EST17b (Sus scrofa)
RHEA:26513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-prolinamide <=> L-proline + NH4(+)
RHEA:68462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a phenolic steroid
REACT:R-XTR-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Xenopus tropicalis)
RHEA:36628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytetracosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine
RHEA:40085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-210295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and NKG2D (Homo sapiens)
RHEA:20753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 2 cob(II)alamin + 2 H(+) + 2 H2O => AH2 + 2 aquacob(III)alamin
REACT:R-XTR-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Xenopus tropicalis)
RHEA:30448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine
EC:3.4.22.46	skos:prefLabel	"L-peptidase"
EC:3.4.22.46	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-peptidase"
RHEA:10761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate => acetate + oxaloacetate
REACT:R-CFA-5690845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNIPs bind TNFAIP3 (A20) (Canis familiaris)
REACT:R-HSA-9622604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y (Homo sapiens)
GO:0005310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dicarboxylate (succinate/fumarate/malate) antiporter activity
GO:0005310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dicarboxylic acid transmembrane transporter activity
GO:0005310	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sodium:dicarboxylate/tricarboxylate symporter activity
GO:0005310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dicarboxylic acid permease activity
GO:0005310	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dicarboxylate carrier
RHEA:45963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:24746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine = 2-aminobut-2-enoate + methanethiol
GO:0008755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-antigen polymerase activity
GO:0008755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O antigen polymerase activity
RHEA:44557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-hexaprenyl diphosphate => 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate
REACT:R-SSC-9629149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves thymine glycol from damaged DNA (Sus scrofa)
REACT:R-RNO-191999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Rattus norvegicus)
RHEA:45450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + sphinganine => H2O + N-(dodecanoyl)-sphinganine
RHEA:70248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose => beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP
REACT:R-DRE-83791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Danio rerio)
RHEA:44175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + tetradecanal <=> 2 H(+) + NADH + tetradecanoate
REACT:R-BTA-433089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT can transport taurolithocholate-3-sulphate (Bos taurus)
RHEA:46973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydrobisanhydrobacterioruberin => AH2 + bisanhydrobacterioruberin
GO:0015269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-activated potassium channel activity
REACT:R-HSA-981680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binding protein displaces C2a (Homo sapiens)
REACT:R-CFA-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Canis familiaris)
REACT:R-HSA-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)
REACT:R-BTA-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Bos taurus)
REACT:R-HSA-9737035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate binds GRM1 (mGluR1) (Homo sapiens)
RHEA:56690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2
RHEA:41224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-DME-9638064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Drosophila melanogaster)
RHEA:66911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A
RHEA:41747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)
REACT:R-RNO-420274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIP receptor binds gastric inhibitory peptide (Rattus norvegicus)
REACT:R-RNO-8950340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Rattus norvegicus)
REACT:R-XTR-9700998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 disrupts the BRCA1:BARD1 heterodimer (Xenopus tropicalis)
RHEA:64649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH
RHEA:62904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-BTA-354066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PTK2 to Focal complexes (Bos taurus)
GO:0018802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity
REACT:R-RNO-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Rattus norvegicus)
REACT:R-DRE-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Danio rerio)
REACT:R-RNO-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Rattus norvegicus)
REACT:R-DME-4093331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras:GTP binds p120-RasGAP (Drosophila melanogaster)
RHEA:41321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-XTR-190256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to FGF (Xenopus tropicalis)
RHEA:16010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + formate => ADP + formyl phosphate
RHEA:67029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O => (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate
RHEA:40733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + 2 D-glucose => (20S)-ginsenoside Rg3 + 2 H2O
GO:0140939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4 methyltransferase activity
GO:0140939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H4 methylation
GO:0140939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4 methylase activity
RHEA:30319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NAD(+)
GO:0019140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 3-kinase activity
GO:0019140	skos:altLabel	"myoinositol kinase"
GO:0019140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:myo-inositol 1-phosphotransferase activity
GO:0019140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol 1-kinase activity
GO:0019140	skos:altLabel	"myo-inositol 1-kinase"
GO:0019140	skos:prefLabel	"inositol 3-kinase"
GO:0019140	skos:altLabel	"inositol 1-kinase"
GO:0019140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol-1-kinase (phosphorylating)
GO:0019140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + myo-inositol = 1D-myo-inositol 3-phosphate + ADP + H(+)
GO:0019140	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	myoinositol kinase activity
GO:0019140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol 1-kinase activity
GO:0019140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol 3-kinase"
GO:0019140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol 3-kinase activity
REACT:R-CFA-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Canis familiaris)
REACT:R-SCE-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Saccharomyces cerevisiae)
RHEA:72452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) => a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)
REACT:R-HSA-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Homo sapiens)
REACT:R-DME-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
RHEA:56980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzyl alcohol + 2 oxidized [azurin] = 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]
REACT:R-DRE-5693055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Danio rerio)
REACT:R-RNO-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)
RHEA:54874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-menthone + H(+) + NADPH + O2
RHEA:48253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD2 + UDP-alpha-D-galactose => ganglioside GD1b + H(+) + UDP
GO:0031810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H4 histamine receptor binding
GO:0031810	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H4 histamine receptor ligand
REACT:R-SSC-5625421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The anterograde IFT train dissociates (Sus scrofa)
REACT:R-BTA-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Bos taurus)
REACT:R-MMU-5690245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 binds DNAJB1 (Mus musculus)
RHEA:55266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine
REACT:R-RNO-352103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Rattus norvegicus)
RHEA:41644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA = 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate
RHEA:41644	skos:prefLabel	"2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase"
RHEA:41644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase"
RHEA:62239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine(6-4)cytidine in DNA <=> a cytidine dimer in DNA + H(+)
RHEA:14112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NADP(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADPH
REACT:R-CFA-202212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to LAT (Canis familiaris)
REACT:R-DME-216133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CI from COS (Drosophila melanogaster)
REACT:R-HSA-5676599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF trimer binds BAFFR (Homo sapiens)
REACT:R-DME-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Drosophila melanogaster)
REACT:R-RNO-194642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Rattus norvegicus)
REACT:R-HSA-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Homo sapiens)
RHEA:41324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate
REACT:R-BTA-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Bos taurus)
REACT:R-XTR-4570554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO1 (Xenopus tropicalis)
REACT:R-SSC-977619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Sus scrofa)
RHEA:57063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)
REACT:R-SSC-964800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuromedin-U receptors bind neuromedins U, S (Sus scrofa)
RHEA:35882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:67225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA
REACT:R-XTR-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Xenopus tropicalis)
RHEA:14445	skos:altLabel	"lecithinase D"
RHEA:14445	skos:altLabel	"choline phosphatase"
RHEA:14445	skos:altLabel	"lipophosphodiesterase II"
RHEA:14445	skos:prefLabel	"phospholipase D"
RHEA:14445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:14445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phospholipase D"
RHEA:35715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-versiconal hemiacetal acetate + H2O = (2S-3S)-versiconal hemiacetal + acetate + H(+)
RHEA:38732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol
REACT:R-DRE-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Danio rerio)
REACT:R-SSC-6785361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of FANCD2:FANCI (Sus scrofa)
REACT:R-HSA-8938987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5 (Homo sapiens)
RHEA:24711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose => L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose
REACT:R-BTA-5684052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates MDC1 (Bos taurus)
RHEA:22489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(hydroxymethyl)glutathione => formaldehyde + glutathione
RHEA:43796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-SSC-1602488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by plasmin and trypsin (Sus scrofa)
REACT:R-DME-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Drosophila melanogaster)
REACT:R-MMU-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Mus musculus)
RHEA:35974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate <=> diphosphate + fumitremorgin B
GO:0032866	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	xylose reductase activity
GO:0032866	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-xylose reductase activity
GO:0032866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose:NADP reductase activity
REACT:R-DME-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Drosophila melanogaster)
GO:0047364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desulfoglucosinolate sulfotransferase activity
GO:0047364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desulphoglucosinolate sulphotransferase activity
GO:0047364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS-desulfoglucosinolate sulfotransferase activity
GO:0047364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity
GO:0047364	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity
RHEA:56484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] = gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)
REACT:R-MMU-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Mus musculus)
RHEA:34841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O => 4 H(+) + 5 malonyl-CoA
REACT:R-MMU-8952823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Mus musculus)
GO:0050625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2,4-trihydroxybenzene:NAD oxidoreductase activity
GO:0050625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity
GO:0050625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1,4-benzoquinone reductase activity
GO:0050625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity
GO:0050625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxybenzoquinone reductase activity
GO:0050625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity
REACT:R-HSA-187661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ade-Rib binds AODORA2A and NTRK1,2 (Homo sapiens)
REACT:R-CFA-3296233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T2Rs bind bitter-tasting compounds (Canis familiaris)
REACT:R-GGA-140216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PMAIP1 (NOXA) to mitochondria (Gallus gallus)
RHEA:28959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose(in) + H(+)(in) = D-xylose(out) + H(+)(out)
REACT:R-BTA-203156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-derived TREM-1 ligand binds to TREM-1 (Bos taurus)
REACT:R-XTR-8874208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Xenopus tropicalis)
REACT:R-XTR-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)
REACT:R-MMU-5661116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me3K5-histone H3 (Mus musculus)
REACT:R-DME-445699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Drosophila melanogaster)
REACT:R-MMU-917814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Mus musculus)
REACT:R-SSC-5682802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI3 binds ADAM22,23,synatxin1 (Sus scrofa)
RHEA:63264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine
RHEA:46287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-8877813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND5A,B exchange GTP for GDP on RAB39 (Mus musculus)
REACT:R-GGA-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Gallus gallus)
REACT:R-RNO-109387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Rattus norvegicus)
REACT:R-DDI-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Dictyostelium discoideum)
RHEA:48078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde => a primary alcohol + N,N-dimethyl-4-nitrosoaniline
RHEA:24879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + L-sorbopyranose => 1-dehydro-L-sorbose + AH2
REACT:R-RNO-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Rattus norvegicus)
RHEA:47705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + iso-precytochalasin + NADPH + O2 => cytochalasin Z16 + H2O + NADP(+)
REACT:R-SSC-72231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Cleavage and Polyadenylation Complex (Sus scrofa)
REACT:R-SSC-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Sus scrofa)
REACT:R-SSC-8937767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 dephosphorylates RUNX1 (Sus scrofa)
RHEA:47493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isodeoxycholate + NAD(+)
REACT:R-SSC-8943040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF polyubiquitinates monoubiquitinated PCNA (Sus scrofa)
REACT:R-GGA-8869456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP4 deubiquitinate TRAF2,TRAF6 (Gallus gallus)
REACT:R-HSA-9701569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK- and STAT3-dependent HIF1A gene expression (Homo sapiens)
RHEA:57379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-1-propenyl-L-cysteine sulfoxide <=> (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate
RHEA:53454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol
RHEA:28776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dinoflagellate luciferin + O2 => H(+) + H2O + hnu + oxidized dinoflagellate luciferin
REACT:R-HSA-72124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal A Complex (Homo sapiens)
RHEA:42135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isonocardicin C <=> nocardicin C
REACT:R-HSA-1980125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH binds DTX (Homo sapiens)
REACT:R-HSA-5649723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)
RHEA:22677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H(+) + NADPH + O2 => 7(1)-hydroxychlorophyllide a + H2O + NADP(+)
GO:0106263	skos:altLabel	"lysophosphatidylserine acyltransferase"
GO:0106263	skos:prefLabel	"1-acylglycerophosphoserine O-acyltransferase"
GO:0106263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-acylglycerophosphoserine O-acyltransferase"
GO:0106263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acylglycerophosphoserine O-acyltransferase activity
GO:0106263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA
REACT:R-RNO-156661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Exon Junction Complex (Rattus norvegicus)
GO:0046976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H3-K56 specific)
GO:0046976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-methyltransferase activity (H3-K27 specific)
GO:0046976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 methyltransferase activity
GO:0046976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3K27 methyltransferase activity
GO:0046976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-K27 specific)
GO:0046976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H3-K27 specific)
GO:0046976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 methylase activity
GO:0047626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosyl methionine hydrolase activity
GO:0047626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylmethionine lyase activity
GO:0047626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine hydrolase activity
GO:0047626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylmethionine hydrolase activity
GO:0047626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine cleaving enzyme activity
GO:0047626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmethionine-sulfonium-salt hydrolase activity
REACT:R-HSA-6803400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates PCBP4 expression (Homo sapiens)
REACT:R-CEL-77277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Caenorhabditis elegans)
REACT:R-MMU-9749590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates ALB (Mus musculus)
REACT:R-DRE-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Danio rerio)
REACT:R-CFA-377640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of SRC (Canis familiaris)
RHEA:29660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine(in) => O-acetyl-L-serine(out)
RHEA:56237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine
REACT:R-HSA-9641089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin binds Ub:UBE2N:UBE2V1 (Homo sapiens)
REACT:R-RNO-9626816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds p-S345-NCF1 (Rattus norvegicus)
REACT:R-DME-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
RHEA:32647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin C + S-adenosyl-L-methionine = erythromycin A + H(+) + S-adenosyl-L-homocysteine
RHEA:32647	skos:prefLabel	"erythromycin 3''-O-methyltransferase"
RHEA:32647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"erythromycin 3''-O-methyltransferase"
RHEA:32647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin D + S-adenosyl-L-methionine = erythromycin B + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-2029465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
RHEA:58459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + D-mannose
GO:0045156	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome bc1 complex
GO:0045156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GO:0045156	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome
REACT:R-MMU-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Mus musculus)
REACT:R-XTR-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Xenopus tropicalis)
RHEA:51847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
REACT:R-RNO-197250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)
RHEA:38695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin(in) = a cardiolipin(out)
GO:0016312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1-phosphate + phosphate
GO:0016312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol bisphosphate phosphatase activity
REACT:R-DDI-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Dictyostelium discoideum)
RHEA:60653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline
RHEA:15113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol
REACT:R-HSA-8853319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2 fusions dimerize (Homo sapiens)
GO:0034941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrrole-2-carboxylate decarboxylase activity
REACT:R-HSA-391378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follicle-stimulating hormone receptor can bind FSH (Homo sapiens)
REACT:R-GGA-9756156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes ATV to ATVL (Gallus gallus)
RHEA:69837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => campesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-8853252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2:C3d,C3dg,iC3b binds CD19:CD81 (Sus scrofa)
RHEA:28717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate(out) + 2 H(+)(out) => (R)-malate(in) + 2 H(+)(in)
REACT:R-BTA-2022396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-43) (Bos taurus)
RHEA:16590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + sucrose => 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-D-xylan xylanohydrolase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,4-xylanase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-xylanase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-xylan xylanohydrolase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,4-beta-D-xylanase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-1,4-xylanase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-xylanase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-(1,4)-beta-xylanase(1,4)-beta-xylan 4-xylanohydrolase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	xylanase
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-1,4-beta-xylanase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-xylanase activity
GO:0031176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-xylan xylanohydrolase activity
REACT:R-CEL-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Caenorhabditis elegans)
REACT:R-CFA-193068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates PREG (Canis familiaris)
RHEA:21664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenyl phosphate + H2O = 4-nitrophenol + H(+) + phosphate
RHEA:21664	skos:prefLabel	"4-nitrophenylphosphatase"
RHEA:21664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-nitrophenylphosphatase"
RHEA:29946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) <=> 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)
REACT:R-BTA-448673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of caspase-1 p10/p20 dimer (Bos taurus)
RHEA:69009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-aspartate + 3 NADPH + 3 O2 => 2-nitrobutanedioate + 4 H2O + 3 NADP(+)
REACT:R-BTA-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Bos taurus)
REACT:R-DRE-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Danio rerio)
RHEA:28235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate 5-semialdehyde => (S)-1-pyrroline-5-carboxylate + H(+) + H2O
RHEA:21393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + H2O + NAD(+) => 2-phenylacetate + 2 H(+) + NADH
RHEA:46143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-442291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV2 is a GEF for Rho/Rac family kinases (Danio rerio)
REACT:R-BTA-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Bos taurus)
RHEA:63648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-9627104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP3 (Bos taurus)
REACT:R-MMU-168400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iE-DAP elicits a NOD1 response (Mus musculus)
REACT:R-SSC-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Sus scrofa)
REACT:R-XTR-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Xenopus tropicalis)
RHEA:34491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)
RHEA:34491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N,N'-diacetylbacillosamine = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP
RHEA:34491	skos:prefLabel	"UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolyzing)"
RHEA:34491	skos:altLabel	"UDP-Bac2Ac4Ac 2-epimerase"
RHEA:34491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolyzing)"
REACT:R-CEL-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Caenorhabditis elegans)
REACT:R-BTA-5218809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Bos taurus)
REACT:R-DME-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Drosophila melanogaster)
RHEA:36946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA
RHEA:71657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine in DNA + ADP-D-ribose => an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O
REACT:R-SSC-5684108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 binds phosphorylated RBBP8 (Sus scrofa)
RHEA:20359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-phenylpropanoate + H(+) + NADH + O2
RHEA:67981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-zeacarotene => 7,8-dihydro-beta-carotene
RHEA:15502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + L-glutamine + NADPH
REACT:R-MMU-3159259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAA:MUT binds AdoCbl (Mus musculus)
REACT:R-HSA-139918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BIM by JNK (Homo sapiens)
REACT:R-BTA-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Bos taurus)
REACT:R-SSC-8944262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type X (Sus scrofa)
REACT:R-HSA-5654600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
RHEA:43694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] => ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]
RHEA:55277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol + tetradecanoyl-CoA => 9-cis-retinyl tetradecanoate + CoA
RHEA:12640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP
REACT:R-GGA-8964280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Gq binds BTK (Gallus gallus)
REACT:R-CFA-994140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Canis familiaris)
REACT:R-RNO-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Rattus norvegicus)
RHEA:69748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + succinyl-CoA => (indol-3-yl)acetyl-CoA + succinate
REACT:R-GGA-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Gallus gallus)
RHEA:58964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanal + O2 = H(+) + H2O2 + hexanoate
REACT:R-DRE-5225602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR5 binds Me2sR3-replicative histone H3 (Danio rerio)
GO:0050206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oximinotransferase activity
GO:0050206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transoximinase activity
GO:0050206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-acetone oximinotransferase activity
GO:0050206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oximase activity
GO:0050206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oximinotransaminase activity
GO:0050206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transoximase activity
REACT:R-HSA-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)
REACT:R-CEL-549322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations out of hepatic cells (Caenorhabditis elegans)
REACT:R-HSA-9694454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Replication transcription complex binds SARS-CoV-2 genomic RNA (Homo sapiens)
RHEA:50237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-6803875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds CDK1 and CCNB1 (Drosophila melanogaster)
RHEA:29720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(I)alamin(in) => cob(I)alamin(out)
GO:0031740	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type A cholecystokinin receptor ligand
GO:0031740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type A cholecystokinin receptor binding
RHEA:36908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA
REACT:R-GGA-4093329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SDCBP (Gallus gallus)
RHEA:42251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + CoA
RHEA:32523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nigerose + phosphate = beta-D-glucose 1-phosphate + D-glucose
RHEA:32523	skos:prefLabel	"nigerose phosphorylase"
RHEA:32523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nigerose phosphorylase"
RHEA:29947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-rhamnopyranose(out)
RHEA:51881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,6-trichlorocatechol + O2 => (2Z,4E)-2,3,5-trichloromuconate + H(+)
REACT:R-PFA-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Plasmodium falciparum)
RHEA:68469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate
REACT:R-MMU-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Mus musculus)
REACT:R-HSA-2129385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFAP2, MFAP5 bind microfibrils (Homo sapiens)
REACT:R-DME-6805638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A acetylates TP53 (Drosophila melanogaster)
RHEA:19079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]
REACT:R-XTR-114259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase‑9 to caspase‑9 (Xenopus tropicalis)
REACT:R-DRE-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Danio rerio)
REACT:R-SSC-5229283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCNs bind lipids (Sus scrofa)
REACT:R-SCE-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Saccharomyces cerevisiae)
GO:0001962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	isoglobotriaosylceramide synthase
GO:0001962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3-galactosyltransferase activity
REACT:R-MMU-4827383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Mus musculus)
REACT:R-XTR-418170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB1 binds MAPKs, SRC-1 (Xenopus tropicalis)
RHEA:31769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => 2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
REACT:R-MMU-162721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Mus musculus)
RHEA:31374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine
RHEA:17238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + FMN + H(+) => diphosphate + FAD
REACT:R-XTR-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Xenopus tropicalis)
RHEA:54590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine in 25S rRNA
GO:0047896	skos:altLabel	"dihydroxyacetone synthase"
GO:0047896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity
GO:0047896	skos:prefLabel	"formaldehyde transketolase"
GO:0047896	skos:altLabel	"DHAS"
GO:0047896	skos:altLabel	"glycerone synthase"
GO:0047896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerone synthase activity
GO:0047896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde transketolase activity
GO:0047896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formaldehyde transketolase"
GO:0047896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyacetone synthase activity
GO:0047896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHAS activity
GO:0047896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate + formaldehyde = D-glyceraldehyde 3-phosphate + dihydroxyacetone
REACT:R-HSA-8938199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds the MYL9 gene promoter (Homo sapiens)
REACT:R-DRE-5607731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes p-7S-p100:RELB to form p52:RELB (Danio rerio)
RHEA:52912	skos:prefLabel	"4-hydroxy-3-prenylbenzoate synthase"
RHEA:52912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-3-prenylbenzoate synthase"
RHEA:52912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dimethylallyl-4-hydroxymandelate + O2 = 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O
RHEA:31745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyflavanone + S-adenosyl-L-methionine
REACT:R-SSC-937075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated TAK1 leaves activated TLR receptor complex (Sus scrofa)
RHEA:10124	skos:altLabel	"PAMO"
RHEA:10124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetone monooxygenase"
RHEA:10124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP(+)
RHEA:10124	skos:prefLabel	"phenylacetone monooxygenase"
REACT:R-CFA-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Canis familiaris)
GO:0047321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate:protein phosphotransferase activity
GO:0047321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate-protein phosphotransferase activity
GO:0047321	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	diphosphate:microsomal-membrane-protein O-phosphotransferase activity
GO:0047321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DiPPT
GO:0047321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triphosphate:microsomal-membrane-protein phosphotransferase activity
GO:0047321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate-protein phosphotransferase activity
GO:0047321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triphosphate-protein phosphotransferase activity
REACT:R-SCE-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Saccharomyces cerevisiae)
RHEA:56941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate => 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate
REACT:R-HSA-8853800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARTN binds RET:GFRA1,GFRA3 (Homo sapiens)
REACT:R-RNO-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Rattus norvegicus)
REACT:R-BTA-5610752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R translocates to the nucleus (Bos taurus)
RHEA:45317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin D2 => 11beta-prostaglandin F2 + NADP(+)
REACT:R-XTR-2168886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemopexin binds Hemes (Xenopus tropicalis)
RHEA:36099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + S-adenosyl-L-methionine = methyl benzoate + S-adenosyl-L-homocysteine
RHEA:36099	skos:prefLabel	"benzoate O-methyltransferase"
RHEA:36099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzoate O-methyltransferase"
REACT:R-HSA-2288097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Condensin II complex binds H4K20me1-containing nucleosomes (Homo sapiens)
REACT:R-DDI-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Dictyostelium discoideum)
REACT:R-XTR-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Xenopus tropicalis)
RHEA:67928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O = a 3'-end 3'-phosphouridine-RNA + H(+)
RHEA:61991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(72) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:30555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coenzyme F420-0:L-glutamate ligase"
RHEA:30555	skos:prefLabel	"coenzyme F420-0:L-glutamate ligase"
RHEA:30555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate
REACT:R-XTR-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Xenopus tropicalis)
RHEA:68719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene D
REACT:R-BTA-8952062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 recruits HDAC4 to RUNX3 (Bos taurus)
REACT:R-GGA-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Gallus gallus)
REACT:R-SSC-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Sus scrofa)
REACT:R-DME-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
RHEA:44793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-12 + S-adenosyl-L-methionine => H(+) + menaquinol-12 + S-adenosyl-L-homocysteine
REACT:R-MMU-166538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The bound receptor dimerizes (Mus musculus)
RHEA:33450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carboxylate + NADP(+) <=> 3-dehydro-4-methylzymosterol + CO2 + NADPH
REACT:R-SSC-5607721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NIK (Sus scrofa)
REACT:R-SSC-8952823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Sus scrofa)
RHEA:56079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-MMU-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Mus musculus)
REACT:R-RNO-2327909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN binds collagen I, II, III, VI fibrils (Rattus norvegicus)
RHEA:15074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O => D-glucuronate + N(2),6-disulfo-D-glucosamine
RHEA:22368	skos:altLabel	"L-ru5P"
RHEA:22368	skos:altLabel	"L-ribulose-phosphate 4-epimerase"
RHEA:22368	skos:altLabel	"phosphoribulose isomerase"
RHEA:22368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-ribulose-5-phosphate 4-epimerase"
RHEA:22368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose 5-phosphate = D-xylulose 5-phosphate
RHEA:22368	skos:prefLabel	"L-ribulose-5-phosphate 4-epimerase"
RHEA:22368	skos:altLabel	"ribulose phosphate 4-epimerase"
RHEA:22368	skos:altLabel	"L-ribulose 5-phosphate 4-epimerase"
REACT:R-SSC-6799431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds HIPK1 (Sus scrofa)
REACT:R-DRE-6805399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAF1 phosphorylates TP53 (Danio rerio)
RHEA:70139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0038048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynorphin receptor activity
GO:0038048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kappa-opioid receptor activity
RHEA:38619	skos:prefLabel	"nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase"
RHEA:38619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate beta-D-ribonucleotide + phenol = H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside
RHEA:38619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase"
RHEA:34364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-galactosamine
RHEA:48850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2
REACT:R-CEL-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Caenorhabditis elegans)
RHEA:30435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)
RHEA:30435	skos:prefLabel	"lipid II:glycine glycyltransferase"
RHEA:30435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipid II:glycine glycyltransferase"
RHEA:26519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O
REACT:R-GGA-975103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Gallus gallus)
RHEA:59763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin + UDP-alpha-D-glucose <=> apigenin 7-O-beta-D-glucoside + H(+) + UDP
RHEA:53219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-6814094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds ARFIP2 (Canis familiaris)
GO:0140768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein ADP-ribosyltransferase-substrate adaptor activity
REACT:R-SSC-400097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-beta:G-gamma inhibits Adenylate cyclase (Sus scrofa)
REACT:R-HSA-352385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Homo sapiens)
REACT:R-XTR-4420140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Xenopus tropicalis)
RHEA:67691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O <=> 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate
REACT:R-CEL-196950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)
REACT:R-RNO-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Rattus norvegicus)
REACT:R-HSA-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Homo sapiens)
REACT:R-RNO-6789072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP1 binds bacterial peptidoglycan (Rattus norvegicus)
REACT:R-CFA-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Canis familiaris)
REACT:R-GGA-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Gallus gallus)
REACT:R-HSA-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Homo sapiens)
RHEA:52395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-erythronate <=> 4-phospho-D-erythronate + ADP + H(+)
RHEA:27406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H2O + pyruvate => a ubiquinol + acetate + CO2
REACT:R-RNO-977371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates Factor H-boundC3b (Rattus norvegicus)
RHEA:47053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => alpha-selinene + diphosphate
RHEA:48335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
RHEA:27396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)
RHEA:52758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O
RHEA:48170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine
RHEA:16662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoride + S-adenosyl-L-methionine => 5'-deoxy-5'-fluoroadenosine + L-methionine
REACT:R-DRE-6784399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Danio rerio)
REACT:R-HSA-8987230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Homo sapiens)
RHEA:32111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-resveratrol = 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine
RHEA:33536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lanosteryl ester => a carboxylate + H(+) + lanosterol
RHEA:14693	skos:prefLabel	"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminyltransferase"
RHEA:14693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP
RHEA:14693	skos:altLabel	"dolichyl-phosphate acetylglucosaminyltransferase"
RHEA:14693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminyltransferase"
RHEA:14693	skos:altLabel	"dolichyl-phosphate alpha-N-acetylglucosaminyltransferase"
GO:0052770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxyadenylylated-coenzyme F420 hydrolase activity
GO:0052770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F390-A hydrolase activity
REACT:R-GGA-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Gallus gallus)
REACT:R-BTA-2090037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(6) (Bos taurus)
REACT:R-MMU-8876366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL translocates from endosome lumen to lysosome lumen (Mus musculus)
REACT:R-HSA-5654697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-BTA-3927824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CASP8AP2 with SUMO1 (Bos taurus)
GO:0061923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity
GO:0061923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoillud-7-ene synthase activity
RHEA:60683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic aldehyde + H2O + NADP(+) <=> (+)-artemisinate + 2 H(+) + NADPH
RHEA:10412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+)
REACT:R-MMU-170044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Mus musculus)
REACT:R-CFA-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Canis familiaris)
REACT:R-XTR-201677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Xenopus tropicalis)
REACT:R-CFA-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Canis familiaris)
REACT:R-BTA-377640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of SRC (Bos taurus)
RHEA:45684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-dodecanoyl-sphing-4-enine-1-phosphate(in) = N-dodecanoyl-sphing-4-enine-1-phosphate(out)
RHEA:36198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)
GO:1990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clathrin-uncoating ATPase activity
REACT:R-GGA-205262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Direct recruitment of PI3K to p-KIT (Gallus gallus)
REACT:R-RNO-9027273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Rattus norvegicus)
RHEA:22112	skos:prefLabel	"beta-(isoxazolin-5-on-2-yl)-L-alanine synthase"
RHEA:22112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-(isoxazolin-5-on-2-yl)-L-alanine synthase"
RHEA:22112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)
RHEA:65709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-mannose
REACT:R-BTA-418918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The UDP/CysLT (P2Y17) receptor can bind UTP (Bos taurus)
REACT:R-RNO-5661240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCXR tetramer reduces L-xylulose to xylitol (Rattus norvegicus)
RHEA:58466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP => a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine
RHEA:45244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA
REACT:R-SSC-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Sus scrofa)
RHEA:16519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetone + H(+) + NADH => (R)-1-aminopropan-2-ol + NAD(+)
REACT:R-MMU-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Mus musculus)
REACT:R-MMU-8874078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Mus musculus)
REACT:R-PFA-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Plasmodium falciparum)
REACT:R-HSA-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Homo sapiens)
REACT:R-SSC-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Sus scrofa)
RHEA:18745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"juglone 3-hydroxylase"
RHEA:18745	skos:prefLabel	"juglone 3-hydroxylase"
RHEA:18745	skos:altLabel	"naphthoquinone hydroxylase"
RHEA:18745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)
REACT:R-BTA-5692755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates MAPK6 (Bos taurus)
REACT:R-DME-71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Drosophila melanogaster)
REACT:R-MMU-8851979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL9 binds immune cell surfaces (Mus musculus)
RHEA:48461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate
REACT:R-RNO-193424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
RHEA:62113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-D-aspartate => H2O + iminosuccinate
RHEA:30300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a methylated nucleobase within DNA + O2 => a nucleobase within DNA + CO2 + formaldehyde + succinate
RHEA:62528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxin + 2 Fe(III)-[cytochrome c]
RHEA:61862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxybetaenone + H2O + NADP(+) => dehydroprobetaenone I + H(+) + NADPH + O2
REACT:R-CFA-1614336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Canis familiaris)
REACT:R-XTR-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Xenopus tropicalis)
REACT:R-SSC-449829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11 binds IL11RA (Sus scrofa)
RHEA:45457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoylethanolamine => dodecanoate + ethanolamine
REACT:R-BTA-433711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-homodimerization of nectins (Bos taurus)
REACT:R-SSC-6787737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3R binds CSF3 dimer (Sus scrofa)
REACT:R-DRE-5696960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP49 deubiquitinates H2B (Danio rerio)
RHEA:61206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein] => L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal
REACT:R-DRE-9027043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)
REACT:R-XTR-1855180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Xenopus tropicalis)
REACT:R-GGA-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Gallus gallus)
REACT:R-SSC-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Sus scrofa)
REACT:R-CEL-1013020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Caenorhabditis elegans)
RHEA:51790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-CoA + AMP + H(+) => 2-hydroxybenzoyl-5'-AMP + CoA
RHEA:19243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-9010872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 binds Dystroglycan (Sus scrofa)
RHEA:48512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphinate(out) = ADP + H(+) + phosphate + phosphinate(in)
REACT:R-CFA-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Canis familiaris)
REACT:R-XTR-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Xenopus tropicalis)
RHEA:44538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine
REACT:R-HSA-5688397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)
GO:1901973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline binding
RHEA:22264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,6-trichloropyridin-2-ol + FADH2 + O2 = 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O
RHEA:53781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-muricholate + lithocholoyl-CoA => beta-muricholoyl-CoA + lithocholate
RHEA:70495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + 2 Na(+)(out) = D-glucose(in) + 2 Na(+)(in)
REACT:R-HSA-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Homo sapiens)
REACT:R-RNO-265426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Tenascin (Rattus norvegicus)
RHEA:11534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O2 + NH4(+) => glycine + H2O + O2
GO:2001064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellooligosaccharide binding
RHEA:17717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)
REACT:R-HSA-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Homo sapiens)
REACT:R-CFA-2855020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Canis familiaris)
RHEA:18835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulfobenzoate + 2 H(+) + NADH => 4-formylbenzenesulfonate + H2O + NAD(+)
RHEA:58039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> 8-epi-inunolide + H2O
GO:0032561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanyl ribonucleotide binding
REACT:R-GGA-9647631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds PIPs (Gallus gallus)
EC:4.2.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hydro-lyases"
EC:4.2.1.-	skos:prefLabel	"Hydro-lyases"
RHEA:25455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene A
RHEA:11663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol
RHEA:27855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 4-hydroxybenzoate => 3-geranyl-4-hydroxybenzoate + diphosphate
REACT:R-SPO-6809015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Schizosaccharomyces pombe)
RHEA:24579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H2O <=> H(+) + 2 phosphate
REACT:R-DRE-9661723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)
REACT:R-RNO-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Rattus norvegicus)
RHEA:59322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-beta-D-glucopyranosyl-D-gluconate + H(+) => D-cellobiono-1,5-lactone + H2O
RHEA:67972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + ecdysone = ADP + ecdysone 22-phosphate + H(+)
REACT:R-BTA-2129357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin C-terminal processing (Bos taurus)
REACT:R-CFA-9606151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
REACT:R-SSC-9037761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Sus scrofa)
RHEA:38214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecane-1,2-diol + 2 hexadecanoyl-CoA <=> 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA
REACT:R-BTA-3108203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO2,3 (Bos taurus)
REACT:R-BTA-9018785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds GTP (Bos taurus)
REACT:R-DRE-201810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ligand trap binds the ligand BMP2, blocking BMP signalling (Danio rerio)
GO:0019842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin binding
REACT:R-RNO-3907292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Rattus norvegicus)
REACT:R-HSA-5216234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)
REACT:R-CFA-110376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Canis familiaris)
RHEA:15766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + GTP => adenosylcob(III)inamide phosphate + GDP + H(+)
REACT:R-MMU-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Mus musculus)
GO:1900750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligopeptide binding
GO:1900750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligopeptides binding
GO:1900750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligopeptido binding
GO:1900750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Oligopeptid binding
REACT:R-HSA-9755258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX58 binds SARS-CoV-2 dsRNA intermediates (Homo sapiens)
REACT:R-XTR-73598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Xenopus tropicalis)
GO:0033695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
GO:0033695	skos:prefLabel	"With a quinone or similar compound as acceptor"
GO:0033695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
REACT:R-GGA-433592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Gallus gallus)
REACT:R-HSA-1235037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of VEGFA (Homo sapiens)
REACT:R-MMU-193054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cholesterol to 22beta-hydroxycholesterol (Mus musculus)
REACT:R-SSC-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Sus scrofa)
REACT:R-DRE-1602377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Danio rerio)
RHEA:33479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + lanosterol = CoA + lanosteryl ester
RHEA:61209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-nitro-cGMP + L-cysteinyl-[protein] => H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]
REACT:R-GGA-9627089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP9 is phosphorylated at T125 (Gallus gallus)
RHEA:60568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-tryptophan = N-acetyl-D-tryptophan
REACT:R-DME-109539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Drosophila melanogaster)
RHEA:28730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(in) + H(+)(in) <=> Cu(2+)(out) + H(+)(out)
REACT:R-BTA-189398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
REACT:R-HSA-2168987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLL4 binds NOTCH4 (Homo sapiens)
REACT:R-SSC-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Sus scrofa)
REACT:R-DDI-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Dictyostelium discoideum)
RHEA:16726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phosphatidylglycerol phosphate + H2O => a phosphatidylglycerol + phosphate
REACT:R-HSA-419083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase inactivation by ROCK (Homo sapiens)
REACT:R-GGA-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Gallus gallus)
REACT:R-GGA-5696534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 deubiquitinates TAK1:TAB1 (Gallus gallus)
RHEA:52827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
RHEA:64420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-proline(out) = H(+)(in) + L-alanyl-L-proline(in)
RHEA:33905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine => H2O + O2 + pseudooxynicotine
RHEA:22835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formimidoyl-L-glutamate <=> N-formyl-L-glutamate + NH4(+)
RHEA:68964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanoate + O2 = 2-oxooctadecanoate + H2O2
REACT:R-SSC-183094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds CBL:Beta-Pix (Sus scrofa)
REACT:R-DRE-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Danio rerio)
REACT:R-CFA-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Canis familiaris)
RHEA:46135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADPH + O2 <=> 25-hydroxycholesterol + H2O + NADP(+)
RHEA:65705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose => alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)
GO:0033836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity
GO:0033836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol 7-O-beta-glucosyltransferase activity
GO:0033836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:flavonol 7-O-glucosyltransferase activity
REACT:R-CFA-751027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Canis familiaris)
REACT:R-MMU-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Mus musculus)
REACT:R-DDI-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)
REACT:R-DME-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Drosophila melanogaster)
RHEA:65905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + glyoxylate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine
REACT:R-GGA-8878056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds EP300 (Gallus gallus)
RHEA:25870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acetamidopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1),N(12)-diacetylspermine + O2
RHEA:63744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-1-N-beta-D-glucuronide
REACT:R-DRE-2465890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR2 binds collagen type I, II, III, V, X fibrils (Danio rerio)
REACT:R-CFA-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Canis familiaris)
GO:0000833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol heptakisphosphate 4-kinase activity
GO:0000833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphoinositol-pentakisphosphate 4-kinase activity
GO:0000833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP7 4-kinase activity
REACT:R-HSA-9668335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds LEMD2 (Homo sapiens)
RHEA:52190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => 1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione
REACT:R-HSA-177939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
RHEA:22526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carotenoid phi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative
RHEA:35041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine(out) => spermidine(in)
REACT:R-RNO-4615900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB2 with SUMO3 (Rattus norvegicus)
REACT:R-HSA-8865280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)
RHEA:10915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + AMP + diphosphate + H(+)
REACT:R-CFA-6805785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates PHF20 (Canis familiaris)
REACT:R-HSA-2161506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)
REACT:R-DRE-3788075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by ADAMTS4, ADAMTS5 (Danio rerio)
RHEA:24729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-demethylindolmycin + S-adenosyl-L-methionine <=> H(+) + indolmycin + S-adenosyl-L-homocysteine
REACT:R-CFA-8987104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Canis familiaris)
RHEA:69476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysine = CoA + H(+) + N(6)-acetyl-L-lysine
RHEA:10698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase] => a long-chain fatty acid + ATP + holo-[mycocerosate synthase]
REACT:R-CFA-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Canis familiaris)
REACT:R-MMU-201717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK2-mediated phosphorylation of DVL (Mus musculus)
GO:0050018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-amino-acid dehydrogenase activity
GO:0050018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-amino-acid:NAD+ oxidoreductase (deaminating)
REACT:R-CEL-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Caenorhabditis elegans)
RHEA:54543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]
REACT:R-MMU-6786096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Mus musculus)
REACT:R-MMU-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Mus musculus)
REACT:R-DDI-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Dictyostelium discoideum)
REACT:R-MMU-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Mus musculus)
REACT:R-CFA-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)
RHEA:26218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5649483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)
REACT:R-SSC-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Sus scrofa)
RHEA:52963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyocholate + UDP-alpha-D-glucuronate <=> hyocholoyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-DRE-4570463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Danio rerio)
REACT:R-DDI-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Dictyostelium discoideum)
RHEA:40242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + dodecanedioate <=> AMP + diphosphate + dodecanedioyl-CoA
REACT:R-DRE-375339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Danio rerio)
RHEA:53751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP
RHEA:26302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => (S)-allantoin + CO2
REACT:R-DRE-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
RHEA:52402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH => 4-O-phospho-D-threonate + NAD(+)
GO:0022803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	passive transmembrane transporter activity
GO:0022803	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	porters
GO:0022803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Homo sapiens)
GO:0022803	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uniporter activity z
GO:0022803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	facilitated diffusion
RHEA:54787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide <=> Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
RHEA:46639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrotestosterone + NADP(+) <=> H(+) + NADPH + testosterone
RHEA:44556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-hexaprenyl diphosphate = 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate
RHEA:48910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:66543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + A + H2O <=> AH2 + cholesta-5,7-dien-3beta,25-diol
REACT:R-GGA-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
REACT:R-HSA-9684340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3CLp cleaves pp1ab (Homo sapiens)
RHEA:30498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]
GO:0033411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAA codon-amino acid adaptor activity
GO:0033411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UAA codon-amino acid adaptor activity
REACT:R-PFA-8866405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)
REACT:R-BTA-5693055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Bos taurus)
REACT:R-HSA-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Homo sapiens)
RHEA:63688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)
RHEA:39504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)
RHEA:21175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH
GO:0004100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitin synthase activity
GO:0004100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitin synthetase activity
GO:0004100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitin-UDP acetyl-glucosaminyl transferase activity
GO:0004100	skos:prefLabel	"chitin synthase"
GO:0004100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitin-uridine diphosphate acetylglucosaminyltransferase activity
GO:0004100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitin-UDP N-acetylglucosaminyltransferase activity
GO:0004100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP
GO:0004100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-N-acetylglucosaminosylase activity
GO:0004100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity
GO:0004100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chitin synthase"
GO:0004100	skos:altLabel	"chitin-UDP acetyl-glucosaminyl transferase"
REACT:R-SSC-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Sus scrofa)
REACT:R-DME-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Drosophila melanogaster)
RHEA:70247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP
RHEA:29860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + H2O => 5-deoxy-D-ribose + adenine
REACT:R-DDI-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Dictyostelium discoideum)
RHEA:22875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]
REACT:R-HSA-9665412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 ECD mutants bind TKIs (Homo sapiens)
REACT:R-MMU-5229010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-27 of histone H3 (H3R26) (Mus musculus)
REACT:R-CFA-9611277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds P2RY12 antagonists (Canis familiaris)
RHEA:31390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> alpha-amyrin
REACT:R-RNO-4086132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin phosphoprotein binds integrin alphaVbeta1 (Rattus norvegicus)
REACT:R-DRE-199131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR binds CD226 (Danio rerio)
REACT:R-CEL-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Caenorhabditis elegans)
REACT:R-HSA-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Homo sapiens)
RHEA:36744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptadecasphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine
REACT:R-SSC-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Sus scrofa)
RHEA:19456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate
RHEA:63937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a ubiquinone + protoporphyrinogen IX => 3 a ubiquinol + protoporphyrin IX
REACT:R-BTA-2029475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of AA by iPLA2 upon FCGR activation (Bos taurus)
RHEA:47662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-L-methionine sulfoximine => acetyl-CoA + L-methionine sulfoximine
GO:0004519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endonuclease activity
REACT:R-CEL-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Caenorhabditis elegans)
REACT:R-RNO-1482892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Rattus norvegicus)
REACT:R-RNO-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Rattus norvegicus)
REACT:R-DDI-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Dictyostelium discoideum)
REACT:R-SSC-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Sus scrofa)
REACT:R-HSA-5607751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes (Homo sapiens)
REACT:R-GGA-3928612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KALRN exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
REACT:R-SSC-173720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7 translocates to the plasma membrane (Sus scrofa)
REACT:R-HSA-201603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of PKC theta (Homo sapiens)
REACT:R-DRE-9692738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds HRH2 antagonists (Danio rerio)
REACT:R-DME-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Drosophila melanogaster)
REACT:R-SSC-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Sus scrofa)
RHEA:36697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethyldescarbamoylnovobiocin + dTDP + H(+) => dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid
RHEA:17131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide
GO:0034040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent lipid transmembrane transporter activity
GO:0034040	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lipid-transporting ATPase activity
GO:0034040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled lipid transmembrane transporter activity
REACT:R-BTA-388817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICOS binds ICOSL/B7-H2 (Bos taurus)
RHEA:61601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbD protein]-disulfide + [protein]-dithiol => [DsbB protein]-dithiol + [protein]-disulfide
REACT:R-BTA-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Bos taurus)
EC:3.4.17.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tubulin-glutamate carboxypeptidase"
EC:3.4.17.24	skos:altLabel	"cytosolic carboxypeptidase 1"
EC:3.4.17.24	skos:altLabel	"cytosolic carboxypeptidase 5"
EC:3.4.17.24	skos:prefLabel	"tubulin-glutamate carboxypeptidase"
REACT:R-SSC-6814678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Sus scrofa)
RHEA:24118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O
RHEA:29932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)
REACT:R-HSA-2130349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Generation of CLIP from lip10 (Homo sapiens)
REACT:R-SSC-469659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A1 dehydrogenates TEST to DHTEST (Sus scrofa)
RHEA:68530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-MMU-5607726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Mus musculus)
REACT:R-SSC-265424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Sus scrofa)
REACT:R-BTA-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Bos taurus)
RHEA:36010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:10912	skos:prefLabel	"pantoate--beta-alanine ligase (AMP-forming)"
RHEA:10912	skos:altLabel	"pantothenate synthetase"
RHEA:10912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pantoate--beta-alanine ligase (AMP-forming)"
RHEA:10912	skos:altLabel	"pantoic-activating enzyme"
RHEA:10912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)
RHEA:10912	skos:altLabel	"pantoate-activating enzyme"
REACT:R-CFA-5654607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PPTN11 (Canis familiaris)
RHEA:53279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine = 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B
REACT:R-BTA-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Bos taurus)
REACT:R-RNO-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Rattus norvegicus)
REACT:R-SPO-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Schizosaccharomyces pombe)
RHEA:12063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 5 H(+) + 6 malonyl-CoA <=> 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O
GO:0035374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin sulfate binding
RHEA:33211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) = 2-demethylmenaquinol-7 + CO2 + diphosphate
REACT:R-MMU-174445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap on the C-strand (Mus musculus)
REACT:R-XTR-5696838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Xenopus tropicalis)
REACT:R-SSC-380303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Phospho-Nlp from the centrosome (Sus scrofa)
GO:0015171	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	amino acid transporter activity
GO:0015171	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	amino acid/choline transmembrane transporter activity
GO:0015171	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	general amino acid permease activity
GO:0015171	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxy/aromatic amino acid permease activity
GO:0015171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid permease activity
GO:0015171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid transmembrane transporter activity
REACT:R-CEL-8852522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 dimer:MST1R dimer binds MST1R dimer (Caenorhabditis elegans)
RHEA:60149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate
GO:0050412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity
GO:0050412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG:t-cinnamate glucosyltransferase activity
GO:0050412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinnamate glucosyltransferase activity
GO:0050412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-cinnamate glucosyltransferase activity
GO:0050412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + UDP-alpha-D-glucose = 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP
GO:0050412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity
GO:0050412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cinnamate beta-D-glucosyltransferase"
GO:0050412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinnamate beta-D-glucosyltransferase activity
GO:0050412	skos:prefLabel	"cinnamate beta-D-glucosyltransferase"
GO:0050412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinnamate b-D-glucosyltransferase activity
RHEA:47284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-3000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BORA binds SCF-beta-TrCp1/2 (Caenorhabditis elegans)
REACT:R-CEL-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Caenorhabditis elegans)
REACT:R-GGA-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Gallus gallus)
REACT:R-SCE-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)
GO:0017032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium:amino acid symporter activity
GO:0017032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid:potassium symporter activity
RHEA:16370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + NAD(+) => H(+) + NADH + pyruvate
REACT:R-DME-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Drosophila melanogaster)
RHEA:27380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + ATP <=> (2R)-2-phosphoglycerate + ADP + H(+)
REACT:R-CEL-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Caenorhabditis elegans)
RHEA:27857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate
RHEA:61902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + betaenone B => AH2 + betaenone C
RHEA:44820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-13 + CO2 + diphosphate
REACT:R-CFA-975629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11 reduces RBP2:atRAL to RBP2:atROL (Canis familiaris)
REACT:R-CFA-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Canis familiaris)
RHEA:53858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => NADP(+) + ursocholate
RHEA:65337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin T + H(+) + NADPH + O2 => chrodrimanin A + H2O + NADP(+)
RHEA:55003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-DRE-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Danio rerio)
GO:0046977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAP binding
REACT:R-HSA-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Homo sapiens)
RHEA:33454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]
RHEA:58930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aR,11aR)-3,9-dihydroxypterocarpan + H2O => (3R,4R)-7,2',4'-trihydroxyisoflavanol
REACT:R-HSA-174551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of alternative pathway C5 convertase (Homo sapiens)
RHEA:51052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + A = 5alpha-androst-1-ene-3,17-dione + AH2
RHEA:40850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + FAD + H(+) <=> (2E)-eicosenoyl-CoA + FADH2
REACT:R-CFA-202214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)
REACT:R-HSA-202291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Lck (Homo sapiens)
REACT:R-GGA-983424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of COPII coated vesicle (Gallus gallus)
RHEA:51932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite = 2 Fe(II)-[cytochrome c3] + thiosulfate
RHEA:51932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiosulfate reductase (cytochrome)"
RHEA:51932	skos:prefLabel	"thiosulfate reductase (cytochrome)"
REACT:R-BTA-450434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Bos taurus)
REACT:R-BTA-1169403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 ligase with ISG15:E2 complex (Bos taurus)
REACT:R-BTA-8854738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR binds CSFR (Bos taurus)
REACT:R-BTA-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Bos taurus)
REACT:R-GGA-1296024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in neuroendocrine cells (Gallus gallus)
RHEA:34255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sporulenol = (R)-tetraprenyl-beta-curcumene + H2O
RHEA:34255	skos:prefLabel	"sporulenol synthase"
RHEA:34255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sporulenol synthase"
REACT:R-RNO-9701488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates JAK3 (Rattus norvegicus)
RHEA:13206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monosaccharide 1-phosphate + H(+) + UTP => a UDP-monosaccharide + diphosphate
REACT:R-BTA-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Bos taurus)
REACT:R-MMU-6803892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds BAX (Mus musculus)
REACT:R-HSA-9660615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RB1 does not translocate to the nucleus (Homo sapiens)
GO:0034347	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-lambda binding
GO:0034347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type III interferon binding
RHEA:54558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate => a 5'-end ribonucleotide-tRNA(His) + ATP + H(+)
REACT:R-XTR-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)
REACT:R-DME-170672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Drosophila melanogaster)
REACT:R-BTA-2395869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
EC:3.4.21.121	skos:prefLabel	"Lys-Lys/Arg-Xaa endopeptidase"
EC:3.4.21.121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Lys-Lys/Arg-Xaa endopeptidase"
EC:3.4.21.121	skos:altLabel	"Aeromonas extracellular serine protease"
REACT:R-DRE-8952716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 binds Ragulator:Rag dimers (Danio rerio)
REACT:R-RNO-5692437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANG binds F-actin (Rattus norvegicus)
REACT:R-HSA-9610653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins (Homo sapiens)
RHEA:23595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NADP(+) <=> D-glyceraldehyde + H(+) + NADPH
REACT:R-HSA-188544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of M2 tetramers (Homo sapiens)
REACT:R-CFA-202203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PI3K to plasma membrane (Canis familiaris)
REACT:R-SSC-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)
RHEA:58900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-carboxybiuret hydrolase"
RHEA:58900	skos:prefLabel	"1-carboxybiuret hydrolase"
RHEA:58900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-carboxybiuret + H2O = NH4(+) + urea-1,3-dicarboxylate
REACT:R-DRE-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Danio rerio)
REACT:R-HSA-173636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of classic pathway C5 convertase (Homo sapiens)
REACT:R-BTA-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Bos taurus)
RHEA:42518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-gulonate => H2O + L-gulono-1,4-lactone
RHEA:38043	skos:altLabel	"Delta(4)-palmitoyl-[acyl carrier protein] desaturase"
RHEA:38043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:38043	skos:prefLabel	"acyl-[acyl-carrier-protein] 4-desaturase"
RHEA:38043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-[acyl-carrier-protein] 4-desaturase"
REACT:R-HSA-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Homo sapiens)
REACT:R-HSA-9759445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDN,PREDL diffuse into kidney cells (Homo sapiens)
REACT:R-DME-8939203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Drosophila melanogaster)
RHEA:49217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine-tRNA ligase activity
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonyl-transfer ribonucleate synthetase activity
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonyl-tRNA synthetase activity
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine-transfer ribonucleate synthetase activity
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine:tRNAThr ligase (AMP-forming)
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonyl-transfer RNA synthetase activity
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TRS
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonyl-transfer ribonucleic acid synthetase activity
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine translase activity
GO:0004829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonyl ribonucleic synthetase activity
REACT:R-RNO-77283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Rattus norvegicus)
GO:0052761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-D-glucosaminidase activity
GO:0052761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitosan glucosaminohydrolase activity
GO:0052761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exochitosanase activity
GO:0052761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-1,4-beta-D-glucosaminidase activity
GO:0052761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitosan exo-1,4-beta-D-glucosaminidase activity
RHEA:61073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-(R)-19-hydroxytabersonine + acetyl-CoA => (-)-(R)-19-O-acetyltabersonine + CoA
RHEA:21799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-rhamnose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH
REACT:R-SSC-8951850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Sus scrofa)
RHEA:19484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + succinyl-CoA <=> 3-oxoadipyl-CoA + CoA
RHEA:32613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-hydroxygeranial + NADP(+)
REACT:R-DRE-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Danio rerio)
RHEA:49386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-879909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of STAT5a/b by JAK2 (Sus scrofa)
REACT:R-RNO-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Rattus norvegicus)
REACT:R-HSA-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Homo sapiens)
RHEA:57814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chlorocatechol + NAD(+) + nitrite => 1-chloro-2-nitrobenzene + NADH + O2
RHEA:69050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexanoate + H(+) => H2O + hexano-6-lactone
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-specific malate dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MDH
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malic acid dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent malic dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-malate dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-malic dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malic dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked malate dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-L-malate dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent malate dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-malate dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate (NAD) dehydrogenase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate:NAD+ oxidoreductase activity
GO:0030060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-malate-NAD+ oxidoreductase activity
RHEA:71294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) <=> (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)
REACT:R-RNO-9611751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1,2-agonists bind ADRB1,2 (Rattus norvegicus)
RHEA:30971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene
RHEA:30971	skos:altLabel	"carotene cis-trans isomerase"
RHEA:30971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prolycopene isomerase"
RHEA:30971	skos:altLabel	"carotene isomerase"
RHEA:30971	skos:prefLabel	"prolycopene isomerase"
RHEA:30971	skos:altLabel	"CRTISO"
RHEA:30971	skos:altLabel	"carotenoid isomerase"
REACT:R-XTR-9013021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOB (Xenopus tropicalis)
RHEA:14175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan
GO:0008097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S rRNA binding
REACT:R-HSA-937034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino (Homo sapiens)
RHEA:57276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA
RHEA:47258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-8964280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Gq binds BTK (Sus scrofa)
RHEA:24894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyxanthotoxin + S-adenosyl-L-methionine = isopimpinellin + S-adenosyl-L-homocysteine
REACT:R-BTA-177936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Bos taurus)
REACT:R-CEL-443831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3-zeta binds Raf1 (Caenorhabditis elegans)
REACT:R-MMU-212642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamine transport into neurons (Mus musculus)
RHEA:59407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine <=> D-homoserine
REACT:R-SSC-205286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS interacts with p-KIT (Sus scrofa)
REACT:R-DRE-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Danio rerio)
RHEA:54702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+) => 4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase]
GO:0034327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyltransferase activity
RHEA:53336	skos:altLabel	"tRNA-dihydrouridine synthase 2"
RHEA:53336	skos:prefLabel	"tRNA-dihydrouridine(20) synthase [NAD(P)(+)]"
RHEA:53336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA
RHEA:53336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA
RHEA:53336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-dihydrouridine(20) synthase [NAD(P)(+)]"
RHEA:53930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine => a tertiary amine + S-adenosyl-L-methionine
GO:0019115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde dehydrogenase [NAD(P)+] activity
REACT:R-HSA-8852010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL2 binds activated T cells surface (Homo sapiens)
RHEA:17139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thromboxane A2 => prostaglandin H2
GO:0022849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-gated calcium ion channel activity
REACT:R-SPO-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Schizosaccharomyces pombe)
RHEA:58183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + diphosphate + NADP(+)
REACT:R-BTA-5668629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Bos taurus)
RHEA:18246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + ATP => ADP + CoA + H(+)
RHEA:20452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 <=> 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)
EC:3.6.1.66	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"XTP/dITP diphosphatase"
EC:3.6.1.66	skos:altLabel	"hypoxanthine/xanthine dNTP pyrophosphatase"
EC:3.6.1.66	skos:prefLabel	"XTP/dITP diphosphatase"
REACT:R-RNO-8849353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Rattus norvegicus)
REACT:R-HSA-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)
REACT:R-HSA-444848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 1 binds relaxin 3 (Homo sapiens)
REACT:R-XTR-5686625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAIR1 binds collagen (Xenopus tropicalis)
REACT:R-MMU-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Mus musculus)
REACT:R-HSA-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)
REACT:R-HSA-9706350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates CBL (Homo sapiens)
REACT:R-SSC-8875576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK,CRKL recruits RAC1 GEF to activated MET (Sus scrofa)
REACT:R-CEL-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Caenorhabditis elegans)
REACT:R-DRE-195378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of VEGF proteins (Danio rerio)
REACT:R-RNO-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)
REACT:R-CEL-6803875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds CDK1 and CCNB1 (Caenorhabditis elegans)
RHEA:10549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + O2 => 4-guanidinobutanamide + CO2 + H2O
REACT:R-HSA-9670673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIX is secreted (Homo sapiens)
RHEA:71507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-tocopherol(out) = (+)-alpha-tocopherol(in)
RHEA:58526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(16S)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH
GO:0000510	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H3.2-H4 histone complex chaperone activity
GO:0000510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3-H4 histone complex chaperone activity
GO:0000510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3-H4 histone carrier activity
GO:0000510	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H3.3-H4 histone complex chaperone activity
GO:0000510	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H3.1-H4 histone complex chaperone activity
GO:0102474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity
REACT:R-DRE-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Danio rerio)
RHEA:39344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O
RHEA:31230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine <=> di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP
REACT:R-SSC-2025724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Sus scrofa)
REACT:R-RNO-198266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)
REACT:R-HSA-5684052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates MDC1 (Homo sapiens)
RHEA:30512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinone-8 + H(+) + NADPH => 2-demethylmenaquinol-8 + NADP(+)
RHEA:56636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate
RHEA:30641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-mannose
REACT:R-HSA-9027632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA (Homo sapiens)
REACT:R-RNO-203625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOSTRIN mediated translocation of eNOS from plasma membrane (Rattus norvegicus)
REACT:R-XTR-453200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Xenopus tropicalis)
RHEA:10906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide => [cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A
RHEA:62852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
RHEA:67187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine <=> (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate
REACT:R-DRE-8987156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Danio rerio)
REACT:R-PFA-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Plasmodium falciparum)
RHEA:41501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine
REACT:R-DRE-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Danio rerio)
RHEA:69778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> beta-ylangene + diphosphate
REACT:R-CFA-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Canis familiaris)
REACT:R-BTA-6786171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 deubiquitination by USP1:WDR48 (Bos taurus)
GO:0047356	skos:altLabel	"teichoic-acid synthase"
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPribitol ribitolphosphotransferase activity
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	teichoate synthase activity
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-ribitol ribitolphosphotransferase"
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyribitol phosphate synthetase activity
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyribitol phosphate polymerase activity
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	teichoic-acid synthase activity
GO:0047356	skos:prefLabel	"CDP-ribitol ribitolphosphotransferase"
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	teichoate synthetase activity
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(ribitol phosphate) synthetase activity
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ribitol ribitolphosphotransferase activity
GO:0047356	skos:altLabel	"polyribitol phosphate polymerase"
GO:0047356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)
GO:0047356	skos:altLabel	"teichoate synthase"
REACT:R-SSC-444879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 2 binds relaxin 2 and INSL3 (Sus scrofa)
REACT:R-SCE-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Saccharomyces cerevisiae)
RHEA:28258	skos:prefLabel	"cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase"
RHEA:28258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase"
RHEA:28258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate = cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP
REACT:R-MMU-877281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 binds p-STAT1 dimer (Mus musculus)
REACT:R-DRE-1482689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)
RHEA:65464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-1-ol + butanoyl-CoA = 2-methylbutyl butanoate + CoA
REACT:R-DDI-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Dictyostelium discoideum)
REACT:R-SSC-265428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with VCAM1 (Sus scrofa)
REACT:R-DME-390025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated WTS autophosphorylates (Drosophila melanogaster)
REACT:R-MMU-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Mus musculus)
RHEA:64608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UTP = diphosphate + uridylyl-L-threonyl-[protein]
RHEA:11053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 2 H(+) + NADH + O2 => 4-aminophenol + CO2 + H2O + NAD(+)
GO:0043426	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MyoD binding
GO:0043426	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myogenin binding
GO:0043426	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Myf5 binding
GO:0043426	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Mrf4 binding
GO:0043426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRF binding
RHEA:32754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline(out) <=> choline(in)
RHEA:48257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:49077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene + FMNH2 + O2 => dibenzothiophene 5-oxide + FMN + H(+) + H2O
REACT:R-HSA-9681651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp8 generates RNA primers (Homo sapiens)
RHEA:57511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + staphylopine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate
RHEA:63395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + Fe(II)-heme o + H2O <=> AH2 + Fe(II)-heme i
RHEA:11475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-methyl-L-amino acid + H2O + O2 <=> an L-alpha-amino acid + formaldehyde + H2O2
REACT:R-HSA-8985460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds RB1 (Homo sapiens)
REACT:R-SSC-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Sus scrofa)
EC:7.5.2.4	skos:altLabel	"teichoic-acid-transporting ATPase"
EC:7.5.2.4	skos:prefLabel	"ABC-type teichoic-acid transporter"
EC:7.5.2.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type teichoic-acid transporter"
REACT:R-MMU-8875320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 GEFs exchange GTP for GDP on RAB5 (Mus musculus)
REACT:R-RNO-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Rattus norvegicus)
REACT:R-SSC-1222685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathelicidin LL-37 binds to bacterial cell wall (Sus scrofa)
RHEA:26225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-al + H2O + NAD(+) = abieta-7,13-dien-18-oate + 2 H(+) + NADH
RHEA:26225	skos:altLabel	"abietadienal dehydrogenase"
RHEA:26225	skos:prefLabel	"abieta-7,13-dien-18-al dehydrogenase"
RHEA:26225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"abieta-7,13-dien-18-al dehydrogenase"
RHEA:24705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-alpha-D-glucuronate <=> CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose
RHEA:11416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose
RHEA:11416	skos:prefLabel	"beta-glucogallin O-galloyltransferase"
RHEA:11416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-glucogallin O-galloyltransferase"
RHEA:59235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + hydropyrenol
RHEA:67393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-ATP + H2O => 2-oxo-AMP + diphosphate + H(+)
REACT:R-SSC-194121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-HSA-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Homo sapiens)
GO:0032216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-phosphotidylinositol O-acyltransferase activity
GO:0032216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPI-inositol acyltransferase
GO:0032216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-phosphatidylinositol O-acyltransferase activity
REACT:R-RNO-177937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of EGFR by SRC kinase (Rattus norvegicus)
REACT:R-MMU-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)
RHEA:53765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholate + lithocholoyl-CoA => allocholoyl-CoA + lithocholate
RHEA:22233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + presqualene diphosphate => diphosphate + NADP(+) + squalene
RHEA:12673	skos:altLabel	"nitrilase"
RHEA:12673	skos:prefLabel	"nitrile hydratase"
RHEA:12673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrile hydratase"
RHEA:12673	skos:altLabel	"nitrile hydro-lyase"
RHEA:12673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic amide = a nitrile + H2O
RHEA:50203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
RHEA:44312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate
RHEA:61580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) = (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH
GO:0016018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclophilin
GO:0016018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclosporin A binding
RHEA:30557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + oxidized coenzyme F420-1 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-0
REACT:R-DME-5654562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Drosophila melanogaster)
REACT:R-DRE-976768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3b (Danio rerio)
REACT:R-SSC-8852317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GTSE1 (Sus scrofa)
RHEA:21023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(1-carboxyvinyl)-3-phosphoshikimate <=> chorismate + phosphate
RHEA:67361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-threonyl-L-threonine => 2 L-threonine
REACT:R-DME-1678650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses Heparan sulfate chain(5) (Drosophila melanogaster)
RHEA:54416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-campestan-3-one + NADP(+) = campest-4-en-3-one + H(+) + NADPH
RHEA:32378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene-1,2-diol + NAD(+) <=> 1-hydroxylimonen-2-one + H(+) + NADH
GO:0097625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity basic amino acid transmembrane transporter activity
GO:0097625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity basic amino acid transmembrane transporter activity
RHEA:22102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dibromo-4-hydroxybenzoate + NH4(+) => 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O
REACT:R-XTR-190263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3b binds to FGF (Xenopus tropicalis)
RHEA:41923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)
REACT:R-DME-6808496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)
REACT:R-HSA-3928598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of p190RhoGEF to p-FAK (Homo sapiens)
RHEA:27919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + propanal => 2 H(+) + NADPH + propanoate
RHEA:65394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+) => 4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH
REACT:R-DRE-114275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BAX at the mitochondrial membrane (Danio rerio)
GO:0015250	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aquaporin
GO:0015250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	water channel activity
REACT:R-MMU-5591052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROCR binds Protein C (Mus musculus)
REACT:R-DRE-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Danio rerio)
REACT:R-DME-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Drosophila melanogaster)
REACT:R-DRE-193787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Danio rerio)
REACT:R-HSA-442760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RasGRF (Homo sapiens)
RHEA:54504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-hexaprenyl diphosphate = beta-hexaprene + diphosphate
RHEA:70384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-3-oxosphinganine
RHEA:19019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + NADH + phosphate => (6S)-NADHX + ATP
RHEA:28207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + ATP => ADP + dUMP + H(+)
REACT:R-XTR-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Xenopus tropicalis)
RHEA:41703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)
GO:0140834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain S2 kinase activity
RHEA:62646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z)-eicosadienoate => (5Z,8Z)-eicosadienoate + O2
REACT:R-XTR-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Xenopus tropicalis)
REACT:R-DME-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Drosophila melanogaster)
REACT:R-SSC-173754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Properdin stabilizes C3b:Bb bound to cell surfaces (Sus scrofa)
REACT:R-RNO-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Rattus norvegicus)
GO:0001409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine nucleotide transmembrane transporter activity
GO:0008094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase, acting on DNA
GO:0008094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase activity, acting on DNA
GO:0008094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent activity, acting on DNA
GO:0008094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA dependent ATPase activity
GO:0008094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-dependent ATPase activity
GO:0008094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-dependent adenosinetriphosphatase activity
GO:0008094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosinetriphosphatase (DNA-dependent)
RHEA:40446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + ATP <=> 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)
RHEA:14164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
REACT:R-HSA-3656259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HEXA does not cleave the terminal GalNAc from DS (Homo sapiens)
RHEA:32000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => bicyclogermacrene + diphosphate
REACT:R-RNO-5693584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Rattus norvegicus)
REACT:R-BTA-912527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
RHEA:33636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + docosanoate => AMP + diphosphate + docosanoyl-CoA
RHEA:12215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-fluoren-9-ol + NADP(+) <=> 9H-fluoren-9-one + H(+) + NADPH
RHEA:36760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-DRE-5674130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)
REACT:R-SSC-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Sus scrofa)
RHEA:27741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + guanine
RHEA:23748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP = diphosphate + pppGp(2'-5')A
RHEA:41871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:62915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toralactone <=> 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)
RHEA:30845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) + maleamate => H2O + N-formylmaleamate
RHEA:70590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) <=> acetate + alpha-D-glucosaminyl-[heparan sulfate](n)
GO:0050116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N-dimethylformamide = dimethylamine + formate
GO:0050116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DMFase activity
GO:0050116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylformamidase activity
GO:0050116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylformamidase activity
GO:0050116	skos:prefLabel	"N,N-dimethylformamidase"
GO:0050116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N,N-dimethylformamidase"
GO:0050116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N,N-dimethylformamide amidohydrolase activity
RHEA:23264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH
RHEA:57070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate 4-phosphate + ADP + H(+) => 3-oxoisoapionate + ATP
RHEA:64169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethyl-L-serine => (2S)-2-aminobutanoate + formaldehyde
GO:0048001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Epd dehydrogenase activity
GO:0048001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-erythrose 4-phosphate:NAD+ oxidoreductase activity
GO:0048001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythrose-4-phosphate dehydrogenase activity
GO:0048001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E4PDH
GO:0048001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GapB
GO:0048001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E4P dehydrogenase activity
GO:0048001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythrose 4-phosphate dehydrogenase activity
RHEA:58395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0034056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERE binding
GO:0034056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrogen response element binding
RHEA:40779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminopentanenitrile + H(+) + 2 H2O = L-2-aminopentanoate + NH4(+)
RHEA:49065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => calcitetrol + H2O + 2 oxidized [adrenodoxin]
RHEA:62077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose 6-phosphate + NAD(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADH
REACT:R-BTA-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Bos taurus)
REACT:R-DRE-5362441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Danio rerio)
RHEA:67885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + dopamine => adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)
RHEA:22951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tagatofuranose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
REACT:R-HSA-5632924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates GLS2 transcription (Homo sapiens)
REACT:R-GGA-977615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates MCP/CR1-bound C4b/C3b (Gallus gallus)
RHEA:71543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethyl-dUMP in DNA + ATP = 5-phosphomethyl-dUMP in DNA + ADP + H(+)
GO:0051381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine binding
RHEA:29033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(out) + 2 Na(+)(out) => L-glutamate(in) + 2 Na(+)(in)
RHEA:53059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine
RHEA:52453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:19942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norcoclaurine + S-adenosyl-L-methionine => coclaurine + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-4719413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO2 (Bos taurus)
REACT:R-HSA-3341277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
RHEA:14105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH
GO:0102848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity
REACT:R-BTA-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Bos taurus)
REACT:R-XTR-9708536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)
RHEA:34534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)
RHEA:31607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhodopin = all-trans-lycopene + H2O
RHEA:31607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carotenoid 1,2-hydratase"
RHEA:31607	skos:prefLabel	"carotenoid 1,2-hydratase"
REACT:R-CEL-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Caenorhabditis elegans)
RHEA:62287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + L-proline + L-tryptophan + NADPH <=> (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)
RHEA:69410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,11,17-trione + H(+) + NADH => 11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+)
RHEA:45126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acarbose 7(IV)-phosphate + ADP + H(+) => acarbose + ATP
REACT:R-CFA-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Canis familiaris)
RHEA:18192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)
RHEA:14692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorophenylacetate + NADH + O2 <=> 3,4-dihydroxyphenylacetate + chloride + NAD(+)
REACT:R-XTR-9629492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves spiroiminodihydantoin (Xenopus tropicalis)
RHEA:16536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP
REACT:R-DME-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Drosophila melanogaster)
REACT:R-MMU-429449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk activation leads to SLP-76 activation (Mus musculus)
REACT:R-XTR-8987042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)
REACT:R-HSA-3907292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Homo sapiens)
REACT:R-BTA-201628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at DSVD (85) (Bos taurus)
REACT:R-MMU-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Mus musculus)
REACT:R-BTA-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Bos taurus)
REACT:R-DME-264871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin B1 (Drosophila melanogaster)
RHEA:16937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkylglycerol kinase"
RHEA:16937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)
RHEA:16937	skos:prefLabel	"alkylglycerol kinase"
REACT:R-CFA-9009488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 binds CSF1 (Canis familiaris)
REACT:R-HSA-167084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
GO:0008989	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity
GO:0008989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (guanine-N1-)-methyltransferase activity
GO:0008989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosomal ribonucleate guanine 1-methyltransferase activity
GO:0008989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity
REACT:R-CFA-9733964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Canis familiaris)
GO:1903876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-deoxycortisol binding
RHEA:45163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H(+) <=> acetaldehyde + CO2
REACT:R-CFA-390595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Troponin-C (Canis familiaris)
RHEA:51185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphoserine + H2O => H(+) + octadecanoate + sn-glycero-3-phospho-L-serine
RHEA:30506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-glutamate 5-semialdehyde <=> acetate + L-glutamate 5-semialdehyde
GO:0051119	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sugar/polyol channel activity
GO:0051119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC50A1 transports Glc from cytosol to extracellular region (Homo sapiens)
GO:0051119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sugar transmembrane transporter activity
RHEA:59296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylglycine + 2 L-ascorbate + O2 = an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical
REACT:R-SPO-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Schizosaccharomyces pombe)
RHEA:61786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-fructose => L-allulose
EC:3.2.1.7	skos:prefLabel	"inulinase"
EC:3.2.1.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inulinase"
EC:3.2.1.7	skos:altLabel	"inulase"
REACT:R-CFA-1562641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
REACT:R-DRE-2247512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Danio rerio)
RHEA:26257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroabietadienol + H(+) + NADPH + O2 = dehydroabietadienal + 2 H2O + NADP(+)
REACT:R-RNO-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)
REACT:R-SPO-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Schizosaccharomyces pombe)
REACT:R-CEL-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Caenorhabditis elegans)
REACT:R-RNO-422017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase decanoylates Proghrelin (Rattus norvegicus)
RHEA:36627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytetracosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine
REACT:R-MMU-6801687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Mus musculus)
REACT:R-HSA-5685608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC2B binds KLRF1 dimer (Homo sapiens)
REACT:R-BTA-5661121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Bos taurus)
RHEA:43056	skos:prefLabel	"10-deoxymethynolide syntase"
RHEA:43056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"10-deoxymethynolide syntase"
RHEA:43056	skos:altLabel	"(2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (10-deoxymethynolide forming)"
RHEA:43056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH = 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)
REACT:R-BTA-5623521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A (Bos taurus)
EC:1.3.5.4	skos:prefLabel	"fumarate reductase (quinol)"
EC:1.3.5.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumarate reductase (quinol)"
EC:1.3.5.4	skos:altLabel	"succinate dehydrogenase (menaquinone)"
EC:1.3.5.4	skos:altLabel	"fumarate reductase (menaquinone)"
RHEA:18695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-aminopenicillanate + a carboxylate => H2O + penicillin
REACT:R-BTA-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Bos taurus)
REACT:R-CEL-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Caenorhabditis elegans)
REACT:R-HSA-1028819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes (Homo sapiens)
RHEA:34604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphinganine
RHEA:11852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
REACT:R-DRE-158849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phenol can form a sulfate conjugate (Danio rerio)
REACT:R-HSA-2168886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemopexin binds Hemes (Homo sapiens)
REACT:R-CEL-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)
REACT:R-RNO-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Rattus norvegicus)
REACT:R-CFA-177936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Canis familiaris)
RHEA:25017	skos:prefLabel	"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase"
RHEA:25017	skos:altLabel	"phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase"
RHEA:25017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate
RHEA:25017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase"
RHEA:28159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:53039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:18056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + paraoxon <=> 4-nitrophenol + diethylphosphate + 2 H(+)
REACT:R-BTA-70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer oxidises LACT to PYR (Bos taurus)
REACT:R-HSA-9010815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLITs bind keratan sulfate (Homo sapiens)
REACT:R-XTR-5626220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 binds the mother centriole (Xenopus tropicalis)
RHEA:51437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-alanine => (2R)-2-amino-4-oxopentanoate + CoA
RHEA:43603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosanoyl-[ACP] + H(+) + NADPH <=> 3R-hydroxyeicosanoyl-[ACP] + NADP(+)
REACT:R-MMU-216064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha8beta1 with Tenascin-C (Mus musculus)
RHEA:44973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + hexanoyl-CoA => CoA + O-hexanoyl-(R)-carnitine
RHEA:15602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA + (R)-3-phenyllactate => (E)-cinnamate + (R)-3-phenyllactoyl-CoA
RHEA:22740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+)
REACT:R-BTA-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Bos taurus)
GO:0089702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyl-phosphate glucose phosphotransferase activity
RHEA:31112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + butanoyl-CoA => 3-oxohexanoyl-CoA + CoA
REACT:R-BTA-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Bos taurus)
REACT:R-DRE-6805785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates PHF20 (Danio rerio)
RHEA:38155	skos:prefLabel	"geranyllinalool synthase"
RHEA:38155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (6E,10E)-geranyllinalool + diphosphate
RHEA:38155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranyllinalool synthase"
RHEA:35277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-CoA + H(+) + NADH => 3-hydroxyoctadecanoyl-CoA + NAD(+)
REACT:R-MMU-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Mus musculus)
REACT:R-MMU-177925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)
REACT:R-CFA-8948234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB:4-Hyp collagen propeptides dissociates (Canis familiaris)
REACT:R-DRE-5205652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 recruits Parkin to the outer mitochondrial membrane. (Danio rerio)
RHEA:15583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA => biochanin A 7-O-beta-D-glucoside + malonyl-CoA
REACT:R-MMU-5687465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds RBBP8 (Mus musculus)
REACT:R-SSC-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Sus scrofa)
REACT:R-GGA-166542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-NGF dimer binds to TrkA receptor (Gallus gallus)
RHEA:38141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol
REACT:R-SSC-419490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATP to P2X receptors (Sus scrofa)
REACT:R-SCE-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
REACT:R-BTA-2671885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers:H+ transport extracellular Na+ to cytosol (Bos taurus)
RHEA:37848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-dihydrodaunorubicin + H(+) + NADPH + O2 => daunorubicin + 2 H2O + NADP(+)
RHEA:67895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine <=> 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-9756470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N binds to heme (Homo sapiens)
REACT:R-GGA-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Gallus gallus)
REACT:R-BTA-432129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds and phosphorylates LRP8 (Bos taurus)
REACT:R-BTA-75825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of Cyclin D1 (Bos taurus)
RHEA:62226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ascladiol + NADP(+) => H(+) + NADPH + neopatulin
REACT:R-HSA-8950504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27 binds CRLF1 (Homo sapiens)
REACT:R-HSA-2162187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHB is hydroxylated to DHDB by COQ6 (Homo sapiens)
REACT:R-SSC-176702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Processive Complex and Completed Telomere End (Sus scrofa)
RHEA:54625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + octadecanoyl-CoA => 2-hydroxyoctadecanoyl-CoA + CO2 + succinate
REACT:R-CFA-1295621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)
RHEA:33007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:45915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4E)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)
REACT:R-MMU-212356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL-NICD coactivator complex (Mus musculus)
RHEA:10962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate => (S)-lactate
RHEA:13579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long chain fatty alcohol + a long-chain fatty acid + H(+) => a wax ester + H2O
RHEA:45974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+) => 3-oxochol-4-en-22-oate + H(+) + NADH + O2
REACT:R-BTA-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Bos taurus)
GO:0033412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG codon-amino acid adaptor activity
GO:0033412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UAG codon-amino acid adaptor activity
REACT:R-CEL-1475026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (cytosol) (Caenorhabditis elegans)
RHEA:71071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-cysteine(out) = L-arginine(out) + L-cysteine(in)
GO:0042626	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0042626	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase activity, coupled to movement of substances
GO:0042626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase activity, coupled to transmembrane movement of substances
GO:0042626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-coupled transmembrane transporter activity
GO:0042626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled transmembrane transporter activity
GO:0042626	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	P-P-bond-hydrolysis-driven transporter
GO:0042626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent transmembrane transporter activity
GO:0042626	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	P-P-bond-hydrolysis-driven transmembrane transporter activity
RHEA:14648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-adenosyl-L-methionine <=> H(+) + L-homoserine + S-methyl-5'-thioadenosine
RHEA:46663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + progesterone <=> 5beta-pregnan-3,20-dione + NADP(+)
RHEA:42353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-nicotine + A + H2O => (R)-6-hydroxynicotine + AH2
RHEA:10692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrroloquinoline-quinone synthase"
RHEA:10692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone
RHEA:10692	skos:prefLabel	"pyrroloquinoline-quinone synthase"
RHEA:29095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+)(in) + NADH + ubiquinone-8 = 4 H(+)(out) + NAD(+) + ubiquinol-8
RHEA:55710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide => [ADP-thiazole synthase]-L-cysteine + glycine + NAD(+)
REACT:R-RNO-1482868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Rattus norvegicus)
RHEA:52051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)
RHEA:39386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)
RHEA:11869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NADP(+) => D-ribulose + H(+) + NADPH
REACT:R-DDI-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Dictyostelium discoideum)
REACT:R-SPO-5674496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate MAP2K1 (Schizosaccharomyces pombe)
RHEA:12303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) <=> 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine
RHEA:26545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-piperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + NH4(+)
RHEA:62637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O
RHEA:10250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + dUMP + H(+) => dUTP + H2O
RHEA:68316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,5-triphosphate + phosphate
GO:0047184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysolecithin acyltransferase activity
GO:0047184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-acyl-sn-glycero-3-phosphocholine acyltransferase activity
GO:0047184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity
GO:0047184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acylglycerophosphocholine O-acyltransferase activity
GO:0047184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysophosphatide acyltransferase activity
GO:0047184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity
GO:0047184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity
GO:0047184	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysophosphatidylcholine acyltransferase activity
REACT:R-CFA-8877153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 binds PC (Canis familiaris)
REACT:R-MMU-193369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Mus musculus)
REACT:R-MMU-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Mus musculus)
REACT:R-BTA-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Bos taurus)
RHEA:68892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxybenzoate + ATP + H(+) + NADPH = 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)
RHEA:38641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol
REACT:R-RNO-5622134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRABP1 binds atRA (Rattus norvegicus)
RHEA:21064	skos:altLabel	"glutathione--insulin transhydrogenase"
RHEA:21064	skos:altLabel	"insulin reductase"
RHEA:21064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-disulfide reductase (glutathione)"
RHEA:21064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide
RHEA:21064	skos:prefLabel	"protein-disulfide reductase (glutathione)"
RHEA:47528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isocholate + NADP(+)
RHEA:58481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in mRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate
REACT:R-RNO-6784324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Rattus norvegicus)
GO:0043273	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	single-stranded DNA-dependent CTPase activity
GO:0043273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTPase activity, coupled
GO:0043273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine triphosphatase activity
GO:0043273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTPase activity
GO:0043273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H2O = CDP + H(+) + phosphate
RHEA:63150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + taurine => H2O + N-(9Z-octadecenoyl)-taurine
RHEA:11364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate, water dikinase"
RHEA:11364	skos:prefLabel	"pyruvate, water dikinase"
RHEA:11364	skos:altLabel	"phosphoenolpyruvate synthase"
RHEA:11364	skos:altLabel	"pyruvate,water dikinase"
RHEA:11364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate
GO:0106366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine kinase activity
REACT:R-CFA-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Canis familiaris)
REACT:R-DRE-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Danio rerio)
RHEA:46161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H(+) + NADH => a quinol + NAD(+)
REACT:R-HSA-9007283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
RHEA:18185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + O2 = 5'-dehydroadenosine + H2O2
RHEA:21662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + 2 H(+) + NADPH => benzaldehyde + H2O + NADP(+)
GO:0043955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase
GO:0043955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetyl-coenzyme A synthetase/GroES-like domain
GO:0043955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	AMP-dependent synthetase and ligase
GO:0043955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	enoyl-CoA hydratase/isomerase
GO:0043955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetyl-coenzyme A synthetase
GO:0043955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropionyl-CoA synthetase activity
GO:0043955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy propionyl-CoA synthetase activity
REACT:R-HSA-205132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAGE activates JNK (Homo sapiens)
REACT:R-XTR-9750946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2,6 ubiquitinates NLRC5 (Xenopus tropicalis)
RHEA:30175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 2 plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9
RHEA:30175	skos:altLabel	"plant-type phytoene desaturase"
RHEA:30175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"15-cis-phytoene desaturase"
RHEA:30175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 2 a plastoquinone = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol
RHEA:30175	skos:altLabel	"phytoene desaturase"
RHEA:30175	skos:altLabel	"PDS"
RHEA:30175	skos:prefLabel	"15-cis-phytoene desaturase"
REACT:R-HSA-9007816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds HAND2 (Homo sapiens)
REACT:R-BTA-4085992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DAXX with SUMO1 (Bos taurus)
REACT:R-CEL-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Caenorhabditis elegans)
REACT:R-DRE-8854759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D14 binds RAB11 and ULK1 (Danio rerio)
REACT:R-XTR-9701000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1:BARD1 heterodimer autoubiquitinates (Xenopus tropicalis)
REACT:R-MMU-68954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm2-7 is phosphorylated by DDK (Mus musculus)
REACT:R-DRE-8849463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates SFPQ (Danio rerio)
REACT:R-SSC-4084978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Sus scrofa)
RHEA:23197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine => 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
RHEA:11691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-leucine + tRNA(Leu) <=> AMP + diphosphate + L-leucyl-tRNA(Leu)
RHEA:58018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0042011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-16 binding
GO:0042011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-16 binding
REACT:R-DME-1433456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs (Drosophila melanogaster)
REACT:R-CFA-5654647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
REACT:R-GGA-5419273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of GTP and dissociation of 28S and 39S subunits (Gallus gallus)
REACT:R-CFA-399952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIMK-1 by PAK (Canis familiaris)
REACT:R-HSA-2186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 ubiquitinates SMAD7 (Homo sapiens)
REACT:R-CEL-6787533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Caenorhabditis elegans)
REACT:R-SSC-9026780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Sus scrofa)
REACT:R-HSA-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Homo sapiens)
RHEA:63652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:66288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base
REACT:R-SSC-9013024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors at the plasma membrane (Sus scrofa)
REACT:R-CEL-1253343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds ERBB4s80 (Caenorhabditis elegans)
REACT:R-HSA-9665284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)
REACT:R-HSA-9027044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4 ω-oxidises 14(R)-HDHA to MaR-L2 (Homo sapiens)
RHEA:12696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxypyridine + O-acetyl-L-serine <=> 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)
REACT:R-GGA-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Gallus gallus)
EC:3.2.1.166	skos:altLabel	"Hpa1 heparanase"
EC:3.2.1.166	skos:altLabel	"HPSE"
EC:3.2.1.166	skos:prefLabel	"heparanase"
EC:3.2.1.166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heparanase"
REACT:R-GGA-373134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate + CoASH + ATP <=> succinylCoA + ADP + Pi (Gallus gallus)
REACT:R-RNO-8848864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARAP1 (Rattus norvegicus)
REACT:R-GGA-9013109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GEFs activate RHOC (Gallus gallus)
RHEA:31762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-CFA-4551616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RPA1 (RPA70) with SUMO2,3 (Canis familiaris)
REACT:R-MMU-5654658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS bind to PPTN11 (Mus musculus)
RHEA:57098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + A + methanethiol => AH2 + S-methyl-1-thio-D-xylulose 5-phosphate
GO:0050247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	raucaffricine beta-D-glucosidase activity
GO:0050247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	raucaffricine glucosidase activity
GO:0050247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raucaffricine beta-glucosidase activity
GO:0050247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	raucaffricine beta-D-glucohydrolase activity
GO:0050247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raucaffricine b-glucosidase activity
RHEA:69785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-aminophenyl)succinyl-CoA + succinate => (2-aminophenyl)succinate + succinyl-CoA
RHEA:69800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophanyl-tRNA(Trp) + H2O => D-tryptophan + tRNA(Trp)
RHEA:42291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-[ACP] + H(+) + L-alanine <=> (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]
REACT:R-RNO-508308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Rattus norvegicus)
REACT:R-DME-917744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA loaded synaptic vesicle Docking and Priming (Drosophila melanogaster)
GO:0047121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoquinoline:acceptor 1-oxidoreductase (hydroxylating)
GO:0047121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoquinoline 1-oxidoreductase activity
REACT:R-HSA-936381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD5 deubiquitinates TRAF3 (Homo sapiens)
REACT:R-DRE-2161890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)
REACT:R-CFA-5617143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)
REACT:R-RNO-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Rattus norvegicus)
REACT:R-DDI-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Dictyostelium discoideum)
RHEA:24642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + ergosterol => ergosteryl 3-beta-D-glucoside + H2O
RHEA:38895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)
REACT:R-BTA-981832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMUR2 binds neuromedin-S (Bos taurus)
REACT:R-SSC-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Sus scrofa)
REACT:R-DME-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)
GO:0034831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity
REACT:R-RNO-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Rattus norvegicus)
REACT:R-SSC-156723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF20A (MKL2) by phosphorylation (Sus scrofa)
REACT:R-SCE-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Saccharomyces cerevisiae)
GO:0061710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-threonylcarbamoyladenylate synthase"
GO:0061710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonylcarbamoyladenylate synthase
GO:0061710	skos:prefLabel	"L-threonylcarbamoyladenylate synthase"
GO:0061710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate
RHEA:68082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O
REACT:R-DRE-391913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR2 binds FPR2 ligands (Danio rerio)
REACT:R-BTA-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Bos taurus)
REACT:R-GGA-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Gallus gallus)
REACT:R-SSC-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Sus scrofa)
RHEA:48083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] <=> ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5624127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome target cargo to the primary cilium (Gallus gallus)
GO:0047257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity
GO:0047257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diglucosyl diacylglycerol synthase activity
GO:0047257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MGlcDAG (1->2) glucosyltransferase activity
GO:0047257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoglucosyl diacylglycerol (1->2) glucosyltransferase activity
GO:0047257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diglucosyl diacylglycerol (DGlcDAG) synthase activity
GO:0047257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DGlcDAG synthase activity
REACT:R-RNO-6799409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates TP53 (Rattus norvegicus)
REACT:R-HSA-199014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD96 binds PVR (Homo sapiens)
RHEA:54815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-7-isojasmonate + ATP + L-isoleucine <=> AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate
REACT:R-MMU-975103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Mus musculus)
GO:0018822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrile hydro-lyase activity
GO:0018822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrile hydratase activity
GO:0018822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aliphatic nitrile hydratase activity
GO:0018822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acrylonitrile hydratase activity
GO:0018822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NHase activity
GO:0018822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aliphatic-amide hydro-lyase (nitrile-forming)
GO:0018822	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	3-cyanopyridine hydratase activity
GO:0018822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-NHase activity
GO:0018822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H-NHase activity
REACT:R-DRE-70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Danio rerio)
REACT:R-DRE-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Danio rerio)
REACT:R-SCE-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Saccharomyces cerevisiae)
REACT:R-GGA-1980122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX binds NOTCH1 (Gallus gallus)
RHEA:30084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Cu(+) + 4 H(+) + O2 => 4 Cu(2+) + 2 H2O
REACT:R-XTR-374663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Ezrin (Xenopus tropicalis)
RHEA:71562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-N(alpha)-glycyl-dTMP in DNA + A + H2O <=> 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate
RHEA:41835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-[ACP] + H(+) + NADPH <=> hexanoyl-[ACP] + NADP(+)
RHEA:39377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA
RHEA:37695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
RHEA:54076	skos:prefLabel	"stellata-2,6,19-triene synthase"
RHEA:54076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stellata-2,6,19-triene synthase"
RHEA:54076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + stellata-2,6,19-triene
REACT:R-CEL-2530501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTA:FNTB transfers FARN to GNGT1 (Caenorhabditis elegans)
RHEA:37473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine => 3-methylbutanoyl-CoA + S-adenosyl-L-methionine
RHEA:18477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)
RHEA:18477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-dihydroxybenzoate 3,4-dioxygenase"
RHEA:18477	skos:altLabel	"2,3-dihydroxybenzoic oxygenase"
RHEA:18477	skos:prefLabel	"2,3-dihydroxybenzoate 3,4-dioxygenase"
RHEA:18477	skos:altLabel	"o-pyrocatechuate oxygenase"
RHEA:62990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + NH4(+) => dodecanamide + H2O
REACT:R-SSC-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Sus scrofa)
REACT:R-RNO-6797653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMGDH:FAD oxidatively demethylates DMGLY to SARC (Rattus norvegicus)
RHEA:28417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamylputrescine + H2O + O2 <=> 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)
REACT:R-DDI-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)
GO:0042945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine permease activity
GO:0042945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine transmembrane transporter activity
GO:0042945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-serine transporter activity
RHEA:57314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine 5'-diphosphoramidate + H(+) + L-glutamate => H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine
RHEA:38529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O
RHEA:14652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethyllactenocin + dTDP-beta-L-mycarose <=> demethylmacrocin + dTDP + H(+)
RHEA:38557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + all-trans-retinol + H(+) => an all-trans-retinyl ester + H2O
RHEA:31651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gellan tetrasaccharide unsaturated glucuronosyl hydrolase"
RHEA:31651	skos:altLabel	"gellan tetrasaccharide unsaturated glucuronyl hydrolase"
RHEA:31651	skos:altLabel	"unsaturated glucuronyl hydrolase"
RHEA:31651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine
RHEA:31651	skos:prefLabel	"gellan tetrasaccharide unsaturated glucuronosyl hydrolase"
RHEA:49954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine 1-carboxylate => (10aS)-10,10a-dihydrophenazine-1-carboxylate
REACT:R-MMU-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Mus musculus)
GO:0008714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine monophosphate nucleosidase activity
GO:0008714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP nucleosidase activity
GO:0008714	skos:prefLabel	"AMP nucleosidase"
GO:0008714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP phosphoribohydrolase activity
GO:0008714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O = adenine + D-ribose 5-phosphate
GO:0008714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"AMP nucleosidase"
GO:0008714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylate nucleosidase activity
REACT:R-HSA-201677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)
REACT:R-MMU-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Mus musculus)
REACT:R-RNO-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Rattus norvegicus)
REACT:R-MMU-9017817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-secretase cleaves YBX1:NOTCH3 (Mus musculus)
EC:1.14.14.147	skos:altLabel	"CYP90C1"
EC:1.14.14.147	skos:altLabel	"3-epi-6-deoxocathasterone 23-monooxygenase"
EC:1.14.14.147	skos:prefLabel	"22alpha-hydroxysteroid 23-monooxygenase"
EC:1.14.14.147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"22alpha-hydroxysteroid 23-monooxygenase"
EC:1.14.14.147	skos:altLabel	"CYP90D1"
GO:0005225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	volume-sensitive anion channel activity
GO:0005225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Homo sapiens)
GO:0005225	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	volume-regulated channel
REACT:R-RNO-9725206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds FCERI (Rattus norvegicus)
GO:0031071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine desulfurase activity
GO:0031071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine desulfurylase activity
GO:0031071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SufS
GO:0031071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine:enzyme cysteine sulfurtransferase activity
GO:0031071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Homo sapiens)
GO:0031071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NIFS
GO:0031071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IscS
RHEA:69521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-galactosamino-1,5-lactone => H(+) + N-acetyl-D-galactosaminate
RHEA:64379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2
RHEA:69532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate = 4-amino-4-deoxychorismate
REACT:R-RNO-9021660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds membrane-associated estrogen receptors (Rattus norvegicus)
REACT:R-SSC-9009065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXA1 and GATA3 bind to CCND1 promoter (Sus scrofa)
REACT:R-BTA-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Bos taurus)
RHEA:32040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => AMP + ATP + 2 H(+)
RHEA:55123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)
GO:0047636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity
GO:0047636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADH
GO:0047636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanopine:NAD oxidoreductase activity
GO:0047636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)
GO:0047636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ALPDH
GO:0047636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity
GO:0047636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanopine: NAD oxidoreductase activity
GO:0047636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanopine dehydrogenase activity
RHEA:18994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate
REACT:R-BTA-1482695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Bos taurus)
REACT:R-HSA-352174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Homo sapiens)
REACT:R-SCE-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Saccharomyces cerevisiae)
REACT:R-SPO-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Schizosaccharomyces pombe)
RHEA:14607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + GDP + H(+) => D-glucose 6-phosphate + GDP-alpha-D-glucose
RHEA:42397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine => 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:14004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + glycine <=> CoA + glycocholate + H(+)
RHEA:23299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aceneuramate <=> N-acetyl-D-mannosamine + pyruvate
REACT:R-RNO-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Rattus norvegicus)
REACT:R-SSC-6798257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRS binds NTRK3 (Sus scrofa)
REACT:R-CEL-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)
REACT:R-GGA-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Gallus gallus)
RHEA:64225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + uridine(34) in tRNA => 5-hydroxyuridine(34) in tRNA + A + H2O
RHEA:42891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phosphomevalonate + ATP <=> (R)-3,5-bisphosphomevalonate + ADP + H(+)
RHEA:47975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O
REACT:R-CEL-1678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses CS/HS precursor (Caenorhabditis elegans)
RHEA:14921	skos:prefLabel	"indole-3-acetate beta-glucosyltransferase"
RHEA:14921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-acetate beta-glucosyltransferase"
RHEA:14921	skos:altLabel	"IAA-Glu synthetase"
RHEA:14921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + UDP-alpha-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP
REACT:R-HSA-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Homo sapiens)
RHEA:21936	skos:prefLabel	"putrescine carbamoyltransferase"
RHEA:21936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"putrescine carbamoyltransferase"
RHEA:21936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + putrescine = H(+) + N-carbamoylputrescine + phosphate
RHEA:23965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + H2O + NADP(+) => (E)-ferulate + 2 H(+) + NADPH
RHEA:46280	skos:altLabel	"8-sphingolipid desaturase"
RHEA:46280	skos:prefLabel	"sphingolipid 8-(E)-desaturase"
RHEA:46280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingolipid 8-(E)-desaturase"
RHEA:46280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46280	skos:altLabel	"8 fatty acid desaturase"
GO:0008736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fucose ketol-isomerase activity
GO:0008736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fucose isomerase activity
GO:0008736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fucose aldose-ketose-isomerase activity
REACT:R-GGA-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Gallus gallus)
REACT:R-HSA-9685519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyadenylation of SARS-CoV-1 genomic RNA (plus strand) (Homo sapiens)
GO:0004509	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome p450 XXIA1 activity
GO:0004509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 21-monooxygenase activity
GO:0004509	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP21A1
GO:0004509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	21-hydroxylase activity
GO:0004509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
GO:0004509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 21-hydroxylase activity
REACT:R-BTA-8982640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Bos taurus)
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate:NAD oxidoreductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-CH2-H4folate reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	5,10-methylenetetrahydrofolate reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate reductase (FADH(2)) activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydropteroylglutamate reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methylenetetrahydrofolic acid reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5,N10-methylenetetrahydrofolate reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N(5),N(10)-methylenetetrahydrofolate reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methylenetetrahydrofolate reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate reductase (NADPH) activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate:NADP(+) oxidoreductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylenetetrahydrofolate reductase (NADPH2)
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate:NAD+ oxidoreductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MetF
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5,10-methylenetetrahydrofolate reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate:NAD(+) oxidoreductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydrofolate reductase (FADH) activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	MTHFR activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate:(acceptor) oxidoreductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylenetetrahydrofolate reductase [NAD(P)H]
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydrofolate reductase (FADH2) activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N(5,10)-methylenetetrahydrofolate reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-CH(2)-H(4)folate reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	5,10-methylenetetrahydrofolic acid reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate:NADP+ oxidoreductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
GO:0004489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylenetetrahydrofolate reductase (NADPH(2)) activity
REACT:R-BTA-446894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)
REACT:R-SSC-398040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma activation of PLC beta (Sus scrofa)
RHEA:31842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose
REACT:R-HSA-174202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Securin (Homo sapiens)
REACT:R-SSC-5638009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Sus scrofa)
RHEA:22853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + pyruvate => 3-hydroxypyruvate + L-alanine
REACT:R-HSA-5635102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 is internalized (Homo sapiens)
REACT:R-GGA-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Gallus gallus)
RHEA:31440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => alpha-longipinene + diphosphate
REACT:R-SSC-9674131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)
REACT:R-MMU-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Mus musculus)
REACT:R-MMU-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Mus musculus)
RHEA:11687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylarsonous acid + S-adenosyl-L-methionine <=> dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-73722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of UBF-1:rDNA Promoter (Rattus norvegicus)
REACT:R-SCE-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Saccharomyces cerevisiae)
RHEA:61505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin + UDP-alpha-D-glucose => pelargonidin 3-O-beta-D-glucoside + UDP
RHEA:72947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in)
REACT:R-DRE-9029517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Danio rerio)
RHEA:15235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(II)-[cytochrome c] + 2 H(+) + nitrite => Fe(III)-[cytochrome c] + H2O + nitric oxide
REACT:R-DME-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Drosophila melanogaster)
RHEA:61645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine => 2 Fe(III)-[cytochrome b5] + H2O + L-arginine
REACT:R-BTA-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Bos taurus)
REACT:R-RNO-1675473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B binds JAK2 (Rattus norvegicus)
GO:0015546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphathiazole transporter activity
GO:0015546	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bicyclomycin/sulfathiazole:hydrogen antiporter activity
GO:0015546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfathiazole transmembrane transporter activity
REACT:R-SSC-8849435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 dephosphorylates PTK6 (Sus scrofa)
RHEA:63407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichloropyridine-2,5-diol + FADH2 + O2 <=> 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O
GO:0015190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine transmembrane transporter activity
GO:0015190	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leucine/valine/isoleucine permease activity
GO:0015190	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-leucine transporter activity
GO:0015190	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leucine/isoleucine/valine porter activity
REACT:R-MMU-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Mus musculus)
REACT:R-SCE-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Saccharomyces cerevisiae)
RHEA:58009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside F1 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg1 + H(+) + UDP
RHEA:47401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(9Z-octadecenoyl)-CoA + CoA => (7Z)-hexadecenoyl-CoA + acetyl-CoA
REACT:R-SSC-140870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Sus scrofa)
REACT:R-CFA-751039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (12/13) reassociates with G beta:gamma (Canis familiaris)
REACT:R-DME-9611851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 bind ADR,NAd (Drosophila melanogaster)
REACT:R-CFA-5654651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS3 (Canis familiaris)
REACT:R-RNO-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Rattus norvegicus)
REACT:R-XTR-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Xenopus tropicalis)
RHEA:35980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + verruculogen => diphosphate + fumitremorgin A
GO:0001221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription cofactor binding
GO:0001221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription coregulator binding
GO:0001221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcription coregulator binding
GO:0001221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcription cofactor binding
REACT:R-DRE-983707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates at the activated BCR (Danio rerio)
REACT:R-MMU-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Mus musculus)
RHEA:44291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
GO:0052925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
GO:0052925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity
GO:0052925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity
REACT:R-DDI-174238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Dictyostelium discoideum)
REACT:R-HSA-8854044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)
REACT:R-GGA-8866308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL translocates from RER membrane to SER lumen (Gallus gallus)
REACT:R-RNO-375342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)
REACT:R-SPO-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Schizosaccharomyces pombe)
REACT:R-DRE-1482571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)
RHEA:13674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein-PII]-L-tyrosine + UTP => [protein-PII]-uridylyl-L-tyrosine + diphosphate
REACT:R-XTR-8869425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA1A hydrolyses PS to 2-acyl LPS (Xenopus tropicalis)
REACT:R-CFA-9714477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the mitochondrial outer membrane (Canis familiaris)
RHEA:14545	skos:altLabel	"Nicotine deamidase"
RHEA:14545	skos:prefLabel	"nicotinamidase"
RHEA:14545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinamidase"
RHEA:14545	skos:altLabel	"NAMase"
RHEA:14545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nicotinamide = NH4(+) + nicotinate
RHEA:61868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate
REACT:R-SSC-5671702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP1G2 binds HGS and CHMP2A (Sus scrofa)
REACT:R-CFA-6784189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind LIFR (Canis familiaris)
RHEA:54259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidyl-[protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate
RHEA:55878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aequorin]--coelenterazine => apo-[aequorin] + coelenterazine
REACT:R-HSA-4793955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MGAT2 does not transfer GlcNAc to N-glycans (Homo sapiens)
REACT:R-SSC-9014456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOG (Sus scrofa)
RHEA:14248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O <=> AMP + diphosphate + H(+)
REACT:R-SSC-9634850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT (Sus scrofa)
REACT:R-SSC-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)
REACT:R-SSC-6799722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 oxidoreductase generates unstable semiquinones (Sus scrofa)
GO:0050305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity
GO:0050305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	strombine dehydrogenase activity
GO:0050305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)
GO:0050305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity
RHEA:25511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (1S,5S)-sabinene + diphosphate
RHEA:59024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trihexadecanoylglycerol = dihexadecanoylglycerol + H(+) + hexadecanoate
REACT:R-RNO-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Rattus norvegicus)
RHEA:37011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:56495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hederagenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Sus scrofa)
REACT:R-RNO-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Rattus norvegicus)
RHEA:67297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 => (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2
GO:0047882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)
GO:0047882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estradiol 6b-monooxygenase activity
GO:0047882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estradiol 6beta-hydroxylase activity
GO:0047882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estradiol 6beta-monooxygenase activity
GO:0047882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estradiol 6-beta-monooxygenase activity
GO:0047882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estradiol 6b-hydroxylase activity
GO:0047882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estradiol 6-beta-hydroxylase activity
REACT:R-HSA-8863587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5:p25 translocates to the nucleus (Homo sapiens)
RHEA:52217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1''->2')-ADP-alpha-D-ribose](n) + H2O => [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose
REACT:R-HSA-9734193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective APRT does not convert adenine to AMP (Homo sapiens)
RHEA:43574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + AH2 + NH4(+) => A + D-arginine + H2O
GO:0042656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JUN kinase kinase kinase kinase activity
GO:0042656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JUNKKKK activity
RHEA:20332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[low-density-lipoprotein receptor] <=> ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]
RHEA:17760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionine <=> 3-(methylsulfanyl)propanamine + CO2
REACT:R-CFA-2161293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin forms aggregate globules (Canis familiaris)
REACT:R-XTR-8851827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Xenopus tropicalis)
RHEA:30123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate
REACT:R-DRE-6791221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Danio rerio)
REACT:R-RNO-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Rattus norvegicus)
REACT:R-GGA-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Gallus gallus)
RHEA:36221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-CFA-4570463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Canis familiaris)
REACT:R-DME-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Drosophila melanogaster)
REACT:R-HSA-9627107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP7 (Homo sapiens)
REACT:R-MMU-109338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Mus musculus)
GO:0015385	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pH-dependent sodium:hydrogen antiporter activity
GO:0015385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/hydrogen antiporter activity
GO:0015385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:proton antiporter activity
GO:0015385	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pH-dependent sodium:proton antiporter activity
GO:0015385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:hydrogen exchange activity
GO:0015385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:hydrogen antiporter activity
GO:0015385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:hydrogen exchanger
REACT:R-HSA-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Homo sapiens)
RHEA:19790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(dimethylamino)azobenzene + H2O + NADP(+) => 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH
REACT:R-RNO-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Rattus norvegicus)
RHEA:55728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate
REACT:R-GGA-1168445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B binds the GH receptor complex (Gallus gallus)
REACT:R-RNO-6804266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TTC5 (Rattus norvegicus)
REACT:R-HSA-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Homo sapiens)
REACT:R-CFA-5668534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
REACT:R-HSA-157632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 (Homo sapiens)
RHEA:50498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein] => acetyl-CoA + N-terminal glycyl-[protein]
REACT:R-RNO-430096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds filamin (Rattus norvegicus)
REACT:R-MMU-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Mus musculus)
REACT:R-DME-350453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOGAPP190 binds to RHO1:GTP complex at the plasma membrane (Drosophila melanogaster)
REACT:R-CFA-9681294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6R binds IL6R inhibitors (Canis familiaris)
REACT:R-CFA-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Canis familiaris)
GO:0008545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JNKK
GO:0008545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JUN kinase kinase activity
GO:0008545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
REACT:R-SSC-216064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha8beta1 with Tenascin-C (Sus scrofa)
RHEA:67371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-glutamine <=> acetate + L-glutamine
REACT:R-MMU-2213246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of CLIP from MHC II (Mus musculus)
REACT:R-GGA-9724670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds imiquimod (Gallus gallus)
REACT:R-RNO-9756183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Rattus norvegicus)
REACT:R-CEL-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Caenorhabditis elegans)
RHEA:16558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-3-carboxymuconate 6-semialdehyde + H(+) => 2-aminomuconate 6-semialdehyde + CO2
RHEA:42913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:69692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine => ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP
REACT:R-SSC-113402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:early elongation complex (Sus scrofa)
GO:0047603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetyl CoA deacylase activity
GO:0047603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetyl coenzyme A hydrolase activity
GO:0047603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA hydrolase activity
GO:0047603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetyl coenzyme A deacylase activity
RHEA:36865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O => (9Z)-octadecenoyl-CoA + AH2 + O2
REACT:R-CEL-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)
REACT:R-GGA-5607736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 oligomerizes (Gallus gallus)
REACT:R-MMU-110353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MBD4 glycosylase by APEX1 at the AP site (Mus musculus)
REACT:R-SPO-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Schizosaccharomyces pombe)
RHEA:48101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-SPO-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Schizosaccharomyces pombe)
RHEA:38284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	itaconate + succinyl-CoA => itaconyl-CoA + succinate
RHEA:59225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + hydropyrene
REACT:R-HSA-5218820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src kinases phosphorylate VAV (Homo sapiens)
REACT:R-SSC-5668404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFA binds TNFR2 (Sus scrofa)
REACT:R-DME-2730664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Drosophila melanogaster)
RHEA:27329	skos:altLabel	"urate hydroxylase"
RHEA:27329	skos:altLabel	"FAD-dependent urate oxidase"
RHEA:27329	skos:prefLabel	"FAD-dependent urate hydroxylase"
RHEA:27329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FAD-dependent urate hydroxylase"
RHEA:27329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + urate = 5-hydroxyisourate + H2O + NAD(+)
REACT:R-MMU-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)
REACT:R-HSA-163214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
RHEA:62701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + naphtopyrone YWA1 => acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol
REACT:R-GGA-74712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of IRS-P from insulin receptor (Gallus gallus)
REACT:R-RNO-606326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HJURP:CENPA complex localizes to the centromere (Rattus norvegicus)
GO:0050126	skos:prefLabel	"N-carbamoylputrescine amidase"
GO:0050126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-carbamoylputrescine amidase"
GO:0050126	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoylputrescine hydrolase activity
GO:0050126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-carbamoylputrescine amidase activity
GO:0050126	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-carbamoylputrescine amidohydrolase activity
GO:0050126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-carbamoylputrescine = CO2 + NH4(+) + putrescine
GO:0050126	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NCP
REACT:R-MMU-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Mus musculus)
REACT:R-XTR-5684273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
REACT:R-CFA-2130478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of invariant chain trimer and MHC II alpha beta dimer (Canis familiaris)
RHEA:16674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphonopyruvate + H2O => H(+) + phosphate + pyruvate
REACT:R-RNO-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Rattus norvegicus)
REACT:R-MMU-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Mus musculus)
RHEA:45973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)
RHEA:19676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trihydroxybenzene + O2 <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)
REACT:R-MMU-76354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vinyl chloride is oxidized to 2-Chloroethylene oxide (Mus musculus)
RHEA:20243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylnicotinate + S-adenosyl-L-homocysteine => nicotinate + S-adenosyl-L-methionine
REACT:R-RNO-8854612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 accelerates GTP hydrolysis by RAB33B (Rattus norvegicus)
GO:0005132	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-alpha/beta receptor ligand
GO:0005132	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IFNAR1 binding
GO:0005132	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-alpha/beta
GO:0005132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I interferon receptor binding
GO:0005132	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IFNAR2 binding
GO:0005132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interferon-alpha/beta receptor binding
GO:0005132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IFNAR binding
RHEA:34339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]
REACT:R-HSA-9628444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation  (Homo sapiens)
REACT:R-HSA-6804194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDM1 binds the TP53 gene (Homo sapiens)
REACT:R-RNO-9691566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 binds nicorandil (Rattus norvegicus)
REACT:R-SSC-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Sus scrofa)
REACT:R-HSA-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Homo sapiens)
REACT:R-DME-350450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHO1:GTP complex dissociates from RHOGEF2 (Drosophila melanogaster)
REACT:R-PFA-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Plasmodium falciparum)
RHEA:60921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 => a cytidine in mRNA + CO2 + formaldehyde + succinate
GO:0099108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium channel activator activity involved in G-protein coupled receptor signaling pathway
GO:0099108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium channel activator activity involved in G protein-coupled receptor signaling pathway
REACT:R-HSA-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Homo sapiens)
REACT:R-RNO-997237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B proteins bind JAK2 (Rattus norvegicus)
REACT:R-CEL-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Caenorhabditis elegans)
REACT:R-DME-430021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAN2-PAN3 complex partially deadenylates mRNA (Drosophila melanogaster)
RHEA:68936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + nonanoate = AMP + diphosphate + NADP(+) + nonanal
REACT:R-SPO-9700701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T-type VDCC bind T-type VDCC blockers (Schizosaccharomyces pombe)
REACT:R-GGA-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Gallus gallus)
RHEA:20893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + phosphate => butanoyl phosphate + CoA
GO:0031993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	light transducer activity
REACT:R-MMU-5691154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HFE binds TFRC dimer (Mus musculus)
REACT:R-DRE-5632738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDIT4 binds 14-3-3 dimer (Danio rerio)
REACT:R-BTA-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Bos taurus)
RHEA:30799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH
REACT:R-HSA-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Homo sapiens)
RHEA:12711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP
GO:0004447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thyroid peroxidase activity
GO:0004447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide peroxidase activity
GO:0004447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPO activity
GO:0004447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thyroperoxidase activity
GO:0004447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iodinase activity
REACT:R-CFA-430347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MigFilin associates with Filamin and F-actin (Canis familiaris)
RHEA:70363	skos:prefLabel	"cyanuric acid amidohydrolase"
RHEA:70363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanuric acid amidohydrolase"
RHEA:70363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanurate + H2O = 1-carboxybiuret + H(+)
GO:0004394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan sulfate 2-O-sulfotransferase activity
GO:0004394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS2ST1 sulfates IdoA at C2 in heparan sulfate (Homo sapiens)
GO:0004394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan-sulfate 2-O-sulphotransferase activity
GO:0004394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin 2-sulfotransferase activity
GO:0004394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin-sulphate 2-sulphotransferase activity
RHEA:24507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
REACT:R-CFA-174120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Canis familiaris)
RHEA:58400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptan-1-ol + NADP(+) = H(+) + heptanal + NADPH
REACT:R-BTA-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Bos taurus)
GO:0102615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassadiene-C2-hydroxylase activity
GO:0102615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sodorifen => pre-sodorifen diphosphate
RHEA:39244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)
REACT:R-DRE-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Danio rerio)
REACT:R-DME-5654222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PLCG1 (Drosophila melanogaster)
RHEA:25221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-cysteate = CO2 + taurine
RHEA:61896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone C = betaenone A
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-oxo-L-proline amidohydrolase (ATP-hydrolysing)
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-oxoprolinase (ATP-hydrolysing)
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyroglutamase (ATP-hydrolysing)
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-OPase activity
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyroglutamase (ATP-hydrolyzing) activity
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxoprolinase activity
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxoprolinase (ATP-hydrolyzing) activity
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-pyroglutamate hydrolase activity
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyroglutamic hydrolase activity
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyroglutamate hydrolase activity
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyroglutamase activity
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-oxoprolinase activity
GO:0017168	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-oxo-L-prolinase activity
REACT:R-DRE-8937113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Danio rerio)
REACT:R-PFA-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Plasmodium falciparum)
REACT:R-DRE-4793911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates HSF1 (Danio rerio)
RHEA:20709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + erythritol => ADP + D-erythritol 4-phosphate + H(+)
REACT:R-SSC-174438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate on the C-strand (Sus scrofa)
RHEA:44360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase"
RHEA:44360	skos:prefLabel	"(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase"
RHEA:44360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate
RHEA:44360	skos:altLabel	"phospho-AI-2 isomerase"
REACT:R-HSA-9694542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 binds nsp10 (Homo sapiens)
GO:0018741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkyl sulphatase activity
GO:0018741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkyl sulfatase activity
REACT:R-CEL-9018895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Caenorhabditis elegans)
REACT:R-SCE-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)
REACT:R-BTA-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Bos taurus)
REACT:R-CFA-1237047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ hydrates CO2 to HCO3- (Canis familiaris)
GO:0043998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2A histone lysine N-acetyltransferase activity
GO:0043998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2A histone acetyltransferase activity
GO:0043998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A acetyltransferase activity
GO:0043998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2A histone acetylase activity
RHEA:68191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + phytol <=> CoA + dodecanoate phytyl ester
REACT:R-SSC-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Sus scrofa)
REACT:R-BTA-174448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex on the C-strand of the telomere (Bos taurus)
REACT:R-HSA-9697750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)
RHEA:21589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH
RHEA:43012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine = 2-aminobut-2-enoate + H(+) + hydrogen sulfide
RHEA:37256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-asparagine + H2O => 2-oxosuccinamate + AH2 + NH4(+)
RHEA:36179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:38551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 = (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:45757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine
REACT:R-GGA-140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Gallus gallus)
RHEA:41862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-[ACP] + H2O => (3R)-hydroxydecanoyl-[ACP]
REACT:R-HSA-8879117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT2 transfers GlcNAc to Man-DAG1 (Homo sapiens)
RHEA:46173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoate + CoA => AMP + butanoyl-CoA + diphosphate
REACT:R-HSA-9710914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK fusions bind GRB2 (Homo sapiens)
REACT:R-XTR-2990880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6/NEK7 phosphorylates NUP98 (Xenopus tropicalis)
REACT:R-HSA-195730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of processed viral proteins to the cell membrane (Homo sapiens)
REACT:R-DME-5607724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
RHEA:45211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] <=> Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-DRE-9728150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 binds gliflozins (Danio rerio)
GO:0016501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostacyclin receptor activity
GO:0016501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGI(2) receptor activity
GO:0016501	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGI receptor activity
GO:0016501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin I receptor activity
REACT:R-GGA-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Gallus gallus)
RHEA:38922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphing-4-enine-phosphocholine <=> choline + H(+) + sphing-4-enine 1-phosphate
RHEA:24092	skos:altLabel	"sulochrin oxidase"
RHEA:24092	skos:prefLabel	"sulochrin oxidase [(+)-bisdechlorogeodin-forming]"
RHEA:24092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulochrin oxidase [(+)-bisdechlorogeodin-forming]"
RHEA:24092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O
RHEA:60802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A44 + succinate => 2-oxoglutarate + gibberellin A53 + O2
RHEA:60060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP
GO:0036319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M-factor mating pheromone receptor activity
GO:0036319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mating-type M-factor pheromone receptor activity
GO:0036319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M-factor receptor activity
REACT:R-MMU-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Mus musculus)
REACT:R-SSC-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Sus scrofa)
REACT:R-GGA-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Gallus gallus)
RHEA:58096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetracosanoylglycerol + H2O = glycerol + H(+) + tetracosanoate
REACT:R-HSA-1169405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)
RHEA:47611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA
RHEA:13660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[citrate lyase ACP] + H2O <=> acetate + H(+) + holo-[citrate lyase ACP]
RHEA:44292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
REACT:R-SSC-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Sus scrofa)
REACT:R-DRE-6794355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 binds mGluR1a,5 (Danio rerio)
RHEA:42343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH
REACT:R-DRE-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Danio rerio)
REACT:R-HSA-168297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein (Homo sapiens)
REACT:R-DRE-2454118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cRAL binds to opsin to form 11c-retinyl:RHO (Danio rerio)
REACT:R-XTR-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Xenopus tropicalis)
RHEA:10330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxycarbonyl + H(+) + NADH => an L-glycol + NAD(+)
RHEA:70721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(out) => L-alanine(in)
REACT:R-DRE-9714361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC activates endoplasmic reticulum effectors (Danio rerio)
REACT:R-BTA-5686315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Bos taurus)
GO:0140101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalytic activity, acting on a tRNA
REACT:R-MMU-8938829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Mus musculus)
REACT:R-CEL-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
RHEA:52119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA <=> 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate
REACT:R-CFA-199935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates CREB (Canis familiaris)
REACT:R-PFA-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Plasmodium falciparum)
REACT:R-CFA-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Canis familiaris)
RHEA:60024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-chrysanthemyl diphosphate + H2O = (R,R)-chrysanthemol + diphosphate
RHEA:38622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate beta-D-ribonucleotide + phenol <=> H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside
RHEA:30750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + hexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + FADH2
RHEA:17270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrocin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tylosin
REACT:R-RNO-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Rattus norvegicus)
REACT:R-HSA-1989775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SULT2A1 (Homo sapiens)
REACT:R-BTA-9629918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 translocates to the nucleus (Bos taurus)
REACT:R-CFA-4420117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR2 autophosphorylates (Canis familiaris)
REACT:R-SSC-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Sus scrofa)
REACT:R-CFA-977348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHGDH tetramer dehydrogenates 3PG (Canis familiaris)
REACT:R-DRE-5635843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI translocates to the nucleus (Danio rerio)
REACT:R-XTR-9677320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS1 dimer binds PTGS1 Inhibitors (Xenopus tropicalis)
REACT:R-XTR-76434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of carbon tetrachloride to form a free radical (Xenopus tropicalis)
RHEA:57941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + H(+) + H2O2 => CO2 + 2 H2O + harderoheme III
RHEA:21826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate
GO:0140414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carrier protein activity
GO:0140414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopantetheine-dependent carrier activity
REACT:R-BTA-141026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor Va to factor Vi intermediate form (Bos taurus)
REACT:R-BTA-5638009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Bos taurus)
REACT:R-BTA-205234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of GAB2 to p-KIT (Bos taurus)
REACT:R-CEL-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Caenorhabditis elegans)
RHEA:43591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NORint + UDP-alpha-D-galactose <=> globoside NOR2 + H(+) + UDP
RHEA:16538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O => (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate
REACT:R-PFA-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Plasmodium falciparum)
REACT:R-GGA-5683425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53BP1 at DNA DSBs (Gallus gallus)
REACT:R-DME-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Drosophila melanogaster)
GO:0004075	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin carboxylase (component of acetyl CoA carboxylase) activity
GO:0004075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin carboxylase activity
GO:0004075	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity
REACT:R-XTR-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Xenopus tropicalis)
REACT:R-HSA-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Homo sapiens)
REACT:R-SSC-8987230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Sus scrofa)
REACT:R-RNO-164423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PhosphoChREBP (Thr 666)  is exported to cytosol (Rattus norvegicus)
RHEA:17804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-phenylalanine <=> CoA + H(+) + N-acetyl-L-phenylalanine
RHEA:10210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg)
REACT:R-SPO-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Schizosaccharomyces pombe)
REACT:R-HSA-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Homo sapiens)
REACT:R-GGA-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Gallus gallus)
RHEA:25909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alditol + O2 => an aldose + H2O2
REACT:R-XTR-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Xenopus tropicalis)
GO:0071861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tachykinin receptor binding
RHEA:16174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + dopamine => (S)-norcoclaurine + H2O
RHEA:63549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin-(1-9) + H2O => angiotensin-(1-7) + L-phenylalanyl-L-histidine
REACT:R-GGA-3772430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNBIP1 binds beta-catenin (Gallus gallus)
REACT:R-RNO-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Rattus norvegicus)
REACT:R-SSC-350058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL NCOR corepressor complex (Sus scrofa)
RHEA:46568	skos:prefLabel	"hex-5-enoyl-[acyl-carrier protein] acetylenase"
RHEA:46568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:46568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hex-5-enoyl-[acyl-carrier protein] acetylenase"
RHEA:46568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-381412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP2 binds IGF forming IGF:IGFBP2 (Xenopus tropicalis)
REACT:R-SCE-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Saccharomyces cerevisiae)
RHEA:72911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proatranorin III + S-adenosyl-L-methionine = atranorin + S-adenosyl-L-homocysteine
REACT:R-CFA-2395849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
REACT:R-DRE-420724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds Ca2+ (Danio rerio)
REACT:R-HSA-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
REACT:R-XTR-8937767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 dephosphorylates RUNX1 (Xenopus tropicalis)
RHEA:35342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyicosanoyl-CoA + NADP(+) <=> 3-oxoeicosanoyl-CoA + H(+) + NADPH
REACT:R-CEL-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Caenorhabditis elegans)
REACT:R-DDI-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Dictyostelium discoideum)
REACT:R-XTR-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)
REACT:R-XTR-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Xenopus tropicalis)
RHEA:49070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-GGA-8985201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL (Gallus gallus)
RHEA:38743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol
REACT:R-DRE-2514772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Danio rerio)
GO:0043560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin receptor substrate binding
GO:0043560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRS binding
GO:0043560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRS [protein] binding
GO:0043560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin receptor substrate [protein] binding
RHEA:51232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2
RHEA:68248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine(in) + Na(+)(in) = L-tyrosine(out) + Na(+)(out)
RHEA:16522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:26130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + isopimara-7,15-diene => (+)-copalyl diphosphate
REACT:R-HSA-9007999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 translocates to the nucleus (Homo sapiens)
REACT:R-BTA-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Bos taurus)
REACT:R-HSA-198458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Efflux of glucose from the endoplasmic reticulum (Homo sapiens)
RHEA:20830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2 => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+)
RHEA:20084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methylhexanamide <=> hexanoate + methylamine
REACT:R-SSC-9009526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Sus scrofa)
RHEA:40076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-6-deoxyfutalosine + H(+) + H2O => futalosine + NH4(+)
REACT:R-DRE-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Danio rerio)
REACT:R-BTA-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Bos taurus)
REACT:R-BTA-202212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to LAT (Bos taurus)
RHEA:17780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:55335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydroxyflavone + S-adenosyl-L-methionine <=> a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine
GO:0048019	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	receptor ligand activity
GO:0048019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor antagonist activity
REACT:R-SPO-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Schizosaccharomyces pombe)
REACT:R-GGA-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Gallus gallus)
RHEA:60579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] <=> Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-CFA-5693533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C (ARTEMIS) processes DNA DSB ends (Canis familiaris)
RHEA:24368	skos:prefLabel	"ornithine cyclodeaminase"
RHEA:24368	skos:altLabel	"ornithine cyclase (deaminating)"
RHEA:24368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ornithine cyclodeaminase"
RHEA:24368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine = L-proline + NH4(+)
RHEA:24368	skos:altLabel	"ornithine cyclase"
RHEA:24368	skos:altLabel	"OCD"
REACT:R-MMU-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Mus musculus)
REACT:R-DME-8952625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)
REACT:R-HSA-3240295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Homo sapiens)
REACT:R-PFA-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Plasmodium falciparum)
REACT:R-XTR-5671970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CIT binds KIF14 and PRC1 (Xenopus tropicalis)
RHEA:52079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)
GO:0047556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxyphthalate carboxy-lyase activity
GO:0047556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphthalate decarboxylase activity
GO:0047556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphthalate 2-decarboxylase activity
GO:0047556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)
RHEA:30663	skos:prefLabel	"hapalindole H synthase"
RHEA:30663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H
RHEA:30663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hapalindole H synthase"
RHEA:45868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-BTA-9709842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS binds TOMM70 (Bos taurus)
RHEA:32695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (-)-car-3-ene + diphosphate
REACT:R-BTA-6807565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY is transferred to the phagosome (Bos taurus)
GO:0005142	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-11
GO:0005142	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-11 receptor ligand
GO:0005142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-11 receptor binding
GO:0140751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone octamer sliding activity
GO:0140751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone octamer slider activity
REACT:R-DRE-2002440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen C-propeptides (Danio rerio)
RHEA:19319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate
REACT:R-MMU-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Mus musculus)
REACT:R-DME-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Drosophila melanogaster)
RHEA:45553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine
REACT:R-DRE-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Danio rerio)
RHEA:42029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADH
REACT:R-DRE-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Danio rerio)
REACT:R-GGA-353504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite to the lesion by Pol eta (Gallus gallus)
REACT:R-BTA-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Bos taurus)
GO:0051982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copper-nicotianamine transmembrane transporter activity
GO:0051982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu-NA chelate transporter activity
REACT:R-DRE-4641236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates FZD to potentiate WNT signaling (Danio rerio)
GO:0061649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin modification-dependent histone binding
GO:0061649	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquitinated histone binding
RHEA:30004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
RHEA:69220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-glucosinolate + H2O = a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)
RHEA:11330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + neryl diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate
REACT:R-XTR-70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate + H2O => 4-imidazolone-5-propionate (Xenopus tropicalis)
REACT:R-CEL-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Caenorhabditis elegans)
GO:0030366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdopterin synthase activity
GO:0140457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein demethylase activity
REACT:R-BTA-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Bos taurus)
REACT:R-BTA-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Bos taurus)
RHEA:34282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,poly-cis-dolichol + NADP(+) <=> di-trans,cis-polyprenol + H(+) + NADPH
REACT:R-DRE-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Danio rerio)
REACT:R-GGA-72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of mRNA at the 3'-end (Gallus gallus)
REACT:R-MMU-197268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)
RHEA:35287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + chloramphenicol(in) + H2O = ADP + chloramphenicol(out) + H(+) + phosphate
REACT:R-HSA-9621073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Immediate Early (IE) Gene Expression (Homo sapiens)
GO:0015078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton transporter activity
GO:0015078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen ion transmembrane transporter activity
GO:0015078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton transmembrane transporter activity
REACT:R-DME-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Drosophila melanogaster)
RHEA:68910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + NADP(+) + picolinal => ATP + H(+) + NADPH + picolinate
REACT:R-CFA-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Canis familiaris)
REACT:R-BTA-3322016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Bos taurus)
GO:1905948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled 3',5'-cyclic GMP transmembrane transporter activity
GO:1905948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 3',5'-cyclic GMP transmembrane transporter activity
GO:1905948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP transmembrane-transporting ATPase activity
GO:1905948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled cGMP transmembrane transporter activity
GO:1905948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type 3',5'-cyclic GMP transmembrane transporter activity
RHEA:10043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H2O <=> AMP + phosphate
REACT:R-HSA-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Homo sapiens)
REACT:R-CEL-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Caenorhabditis elegans)
RHEA:10367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dodecanoyl-CoA + H2O <=> (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)
RHEA:15770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + ATP => adenosylcob(III)inamide phosphate + ADP + H(+)
RHEA:41591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)
RHEA:45189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-350869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Rattus norvegicus)
REACT:R-DME-1497869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - Sepiapterin is reduced to BH2 (Drosophila melanogaster)
REACT:R-RNO-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Rattus norvegicus)
REACT:R-HSA-9648089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6 and NEK7 phosphorylate EML4 (Homo sapiens)
REACT:R-HSA-5625959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Homo sapiens)
REACT:R-GGA-3900194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates DDX5 with SUMO2 (Gallus gallus)
RHEA:17919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Glu(-Cys)](n+1)-Gly + glycine => [Glu(-Cys)](n)-Gly + glutathione + H(+)
REACT:R-RNO-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Rattus norvegicus)
REACT:R-HSA-9694575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein translocates to the plasma membrane (Homo sapiens)
REACT:R-HSA-879362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGER binds ERK1/2 (Homo sapiens)
RHEA:36206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)
RHEA:26375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + prostamide H2 => [thioredoxin]-disulfide + prostamide F2alpha
REACT:R-RNO-5218827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 (NOX2) complex binds RAC1 (Rattus norvegicus)
REACT:R-SSC-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Sus scrofa)
RHEA:49620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythritol 1-phosphate + NADP(+) = D-erythrulose 1-phosphate + H(+) + NADPH
RHEA:49620	skos:prefLabel	"D-erythritol 1-phosphate dehydrogenase"
RHEA:49620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-erythritol 1-phosphate dehydrogenase"
REACT:R-DDI-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Dictyostelium discoideum)
REACT:R-BTA-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Bos taurus)
RHEA:21910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + naphthalene-1,3,6,8-tetrol => NADP(+) + scytalone
REACT:R-XTR-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Xenopus tropicalis)
RHEA:12079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic primary alcohol + NAD(+) <=> an aromatic aldehyde + H(+) + NADH
REACT:R-HSA-2272753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and KIR2DS4 (Homo sapiens)
REACT:R-SCE-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Saccharomyces cerevisiae)
REACT:R-HSA-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Homo sapiens)
REACT:R-BTA-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Bos taurus)
RHEA:31248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prop-2-ynal + pyrroloquinoline quinol => prop-2-yn-1-ol + pyrroloquinoline quinone
RHEA:32878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + H2O <=> a fatty acid + glycerol + H(+)
REACT:R-SCE-3232162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates MITF with SUMO1 (Saccharomyces cerevisiae)
RHEA:41548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)-tetracenomycin-C 4'-O-methyltransferase"
RHEA:41548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine
RHEA:41548	skos:prefLabel	"8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)-tetracenomycin-C 4'-O-methyltransferase"
REACT:R-HSA-429441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK activation by SRC (Homo sapiens)
REACT:R-XTR-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)
REACT:R-DRE-6784189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind LIFR (Danio rerio)
REACT:R-SSC-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Sus scrofa)
REACT:R-MMU-2161660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGE2 by PTGES (Mus musculus)
RHEA:69667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + luteolin 4'-O-beta-D-glucoside = beta-D-glucose + luteolin
RHEA:60806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A17 + H(+) + succinate => 2-oxoglutarate + gibberellin A19 + O2
REACT:R-XTR-2671885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers:H+ transport extracellular Na+ to cytosol (Xenopus tropicalis)
RHEA:68558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine
RHEA:65226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + naphthalene-1,2-diol => (1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+)
RHEA:34215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) = 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH
RHEA:34215	skos:prefLabel	"3-succinoylsemialdehyde-pyridine dehydrogenase"
RHEA:34215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-succinoylsemialdehyde-pyridine dehydrogenase"
REACT:R-GGA-8987033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Gallus gallus)
REACT:R-DRE-71335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Danio rerio)
REACT:R-CFA-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Canis familiaris)
RHEA:19814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-asparagine => 2-oxosuccinamate + an L-alpha-amino acid
REACT:R-BTA-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Bos taurus)
RHEA:51739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-CFA-170126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin B1 in the CRS domain (Canis familiaris)
RHEA:72677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) => 3',5'-cyclic CMP + H2O
RHEA:32663	skos:prefLabel	"2-ketoarginine methyltransferase"
RHEA:32663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-ketoarginine methyltransferase"
RHEA:32663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine = 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine
RHEA:51579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phloretin + UDP-alpha-D-glucose <=> H(+) + phlorizin + UDP
RHEA:11643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3R)-flavan-3-ol + 2 NAD(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH
GO:0070181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SSU rRNA binding
GO:0070181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18S rRNA binding
GO:0070181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small ribosomal subunit rRNA binding
REACT:R-SSC-139893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Granzyme-B activates BID by cleavage (Sus scrofa)
REACT:R-XTR-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Xenopus tropicalis)
RHEA:57788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite
REACT:R-CEL-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)
RHEA:39038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-hydroxy fatty acid + NAD(+) <=> an omega-oxo fatty acid + H(+) + NADH
RHEA:13748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascopyrone M <=> microthecin
REACT:R-MMU-114544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p115-RhoGEF activation of RHOA (Mus musculus)
REACT:R-DRE-8874202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the cytosol to the nucleus (Danio rerio)
REACT:R-SSC-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Sus scrofa)
RHEA:42819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol <=> cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
RHEA:33539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosteryl ester + H2O = a carboxylate + ergosterol + H(+)
REACT:R-MMU-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Mus musculus)
RHEA:59089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine
REACT:R-CFA-202453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Canis familiaris)
REACT:R-DME-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Drosophila melanogaster)
GO:0102893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betanidin 6-O-glucosyltransferase activity
REACT:R-HSA-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Homo sapiens)
REACT:R-DRE-4332235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds TGFBR2 (Danio rerio)
GO:0016435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (guanine) methyltransferase activity
REACT:R-HSA-549322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations out of hepatic cells (Homo sapiens)
REACT:R-DRE-9641089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin binds Ub:UBE2N:UBE2V1 (Danio rerio)
REACT:R-HSA-374689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neogenin binds Netrin-1 (Homo sapiens)
RHEA:20275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2
REACT:R-MMU-5607724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)
REACT:R-BTA-9748983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)
RHEA:19991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-5-thio-alpha-D-ribose 1-phosphate
RHEA:10847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + pyridoxamine <=> L-aspartate + pyridoxal
REACT:R-HSA-1247497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds neuregulins (Homo sapiens)
RHEA:33339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine
REACT:R-RNO-433698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-CFA-8877311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB31 GEFs exchange GTP for GDP on RAB31 (Canis familiaris)
RHEA:35754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + kanosamine <=> ADP + D-kanosamine 6-phosphate + H(+)
REACT:R-DRE-4085331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-1 SUMOylates PARK7 with SUMO1 (Danio rerio)
RHEA:40043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + L-glutamate = ADP + beta-citrylglutamate + H(+) + phosphate
RHEA:40043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-citrylglutamate synthase"
RHEA:40043	skos:altLabel	"NAAGS-I"
RHEA:40043	skos:prefLabel	"beta-citrylglutamate synthase"
RHEA:40043	skos:altLabel	"NAAG synthetase I"
REACT:R-CEL-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Caenorhabditis elegans)
REACT:R-DRE-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Danio rerio)
RHEA:30879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + prop-2-ynal = 2 H(+) + NADH + propynoate
RHEA:29208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol(in) + dimethyl sulfoxide(out) => a menaquinone(in) + dimethyl sulfide(out) + H2O(out)
REACT:R-XTR-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Xenopus tropicalis)
RHEA:15780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O <=> 1-guanidino-1-deoxy-scyllo-inositol + phosphate
REACT:R-DDI-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Dictyostelium discoideum)
REACT:R-DME-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Drosophila melanogaster)
REACT:R-XTR-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Xenopus tropicalis)
RHEA:22397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => glycolaldehyde + guaiacol + H2O + vanillin
REACT:R-BTA-2309779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer binds PTGS2 inhibitors (Bos taurus)
REACT:R-CFA-390909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds hist (Canis familiaris)
RHEA:52196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-cysteine(out) => ADP + H(+) + L-cysteine(in) + phosphate
REACT:R-HSA-6811508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2-bound EP300 acetylates TP53 (Homo sapiens)
RHEA:41552	skos:prefLabel	"ophiobolin F synthase"
RHEA:41552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ophiobolin F synthase"
RHEA:41552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + ophiobolin F
REACT:R-HSA-8854302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D7 binds the TSC1-TSC2 complex (Homo sapiens)
RHEA:65146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + preaustinoid A + succinate => 2-oxoglutarate + berkeleyone A + O2
RHEA:44932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate
REACT:R-CFA-202472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TRAF6 to CBM complex (Canis familiaris)
RHEA:37736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
GO:0106365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-carotene isomerase"
GO:0106365	skos:prefLabel	"beta-carotene isomerase"
GO:0106365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-carotene isomerase activity
GO:0106365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene = 9-cis-beta-carotene
REACT:R-SSC-419428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR2-5 bind S1P (Sus scrofa)
RHEA:10325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-glycol + NADP(+) => a 2-hydroxycarbonyl + H(+) + NADPH
GO:0001647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled cytokinin receptor activity
GO:0001647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled cytokinin receptor activity
GO:0001647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokinin receptor activity, G-protein coupled
GO:0001647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled cytokinin receptor activity
REACT:R-DRE-9018785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds GTP (Danio rerio)
REACT:R-MMU-8848124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAT3 (Mus musculus)
REACT:R-GGA-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Gallus gallus)
REACT:R-XTR-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)
RHEA:32200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-8931858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Danio rerio)
RHEA:57762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH
GO:0031719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 cannabinoid receptor binding
GO:0031719	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 cannabinoid receptor ligand
REACT:R-RNO-9691215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFR2 dimer (Rattus norvegicus)
REACT:R-HSA-2672196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral serpin blocks caspase-8 activity (Homo sapiens)
REACT:R-DRE-8938431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 and BTN1A1 binds periplakin (PPL) (Danio rerio)
REACT:R-BTA-9022314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates MECP2 (Bos taurus)
RHEA:57085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)
REACT:R-MMU-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Mus musculus)
RHEA:56317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4-hydroxybenzoate + acetyl-CoA => 3-acetylamino-4-hydroxybenzoate + CoA
REACT:R-HSA-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Homo sapiens)
RHEA:10885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,24(1)R)-fucosterol epoxide => acetaldehyde + desmosterol
REACT:R-RNO-4551721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VHL with SUMO1 (Rattus norvegicus)
RHEA:62479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)
REACT:R-HSA-1912352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of Pre-NOTCH (Homo sapiens)
REACT:R-BTA-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Bos taurus)
REACT:R-HSA-202248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma1 (Homo sapiens)
RHEA:57505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate
RHEA:18603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + CO2 => 3,4-dihydroxyphthalate + H(+)
RHEA:51653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH
RHEA:55476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine
RHEA:38786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:30651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + O2 + urate = allantoin + CO2 + H2O2
REACT:R-DRE-8983876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds IL12RB2:IL12RB2 (Danio rerio)
RHEA:63379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0140945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H4K4 methylation
GO:0140945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K4 monomethylase activity
GO:0140945	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H4-K4 methylation
GO:0140945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K4 monomethyltransferase activity
GO:0140945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-monomethyltransferase activity (H3-K4 specific)
REACT:R-XTR-8944233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIX (Xenopus tropicalis)
RHEA:20415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine => glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine
REACT:R-MMU-6791218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
RHEA:25380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methylhexadecanoyl-CoA => 2-methylpentadecanal + formyl-CoA
RHEA:60929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)
REACT:R-GGA-934604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)
REACT:R-SSC-1602417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Sus scrofa)
RHEA:64584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate(out) + Na(+)(out) = 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)
REACT:R-CFA-1602458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP10 (Canis familiaris)
REACT:R-HSA-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Homo sapiens)
REACT:R-DRE-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-XTR-5696213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to methylarsonite (Xenopus tropicalis)
REACT:R-MMU-8959510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)
REACT:R-RNO-159728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-prothrombin to prothrombin (Rattus norvegicus)
GO:0033188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylcholine:ceramide cholinephosphotransferase activity
GO:0033188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ceramide:phosphatidylcholine cholinephosphotransferase activity
GO:0033188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingomyelin synthase activity
GO:0033188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SMS2
GO:0033188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SMS1
GO:0033188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SM synthase activity
RHEA:26322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	resorcinol + S-adenosyl-L-methionine => 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine
RHEA:38241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA => (9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA
REACT:R-MMU-9619355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the cytosol (Mus musculus)
REACT:R-DDI-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Dictyostelium discoideum)
REACT:R-RNO-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Rattus norvegicus)
REACT:R-DRE-9611751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1,2-agonists bind ADRB1,2 (Danio rerio)
REACT:R-MMU-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Mus musculus)
RHEA:66285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tomatidine + UDP-alpha-D-glucose => H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP
RHEA:65685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine
RHEA:48697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol
REACT:R-DME-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Drosophila melanogaster)
REACT:R-RNO-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)
RHEA:22783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-GGA-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Gallus gallus)
REACT:R-RNO-8849463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates SFPQ (Rattus norvegicus)
RHEA:59998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + reduced [electron-transfer flavoprotein] => 3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-CFA-141423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the MCC complex to the APC/C complex (Canis familiaris)
RHEA:12875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + H(+) + NADPH => (R)-2-hydroxy-4-methylpentanoate + NADP(+)
REACT:R-SSC-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Sus scrofa)
REACT:R-BTA-202960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of C-IAP1 (Bos taurus)
RHEA:38342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb1 + H2O <=> (20S)-ginsenoside Rd + D-glucose
GO:0086057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in bundle of His cardiac muscle cell action potential
GO:0086057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in bundle of His cell action potential
REACT:R-SSC-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Sus scrofa)
REACT:R-CEL-1564112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VI degradation by MMP2,9,11 (Caenorhabditis elegans)
RHEA:13602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-hydroxy-L-proline + NAD(+) => 4-oxo-L-proline + H(+) + NADH
REACT:R-HSA-112054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Abortive Initiation At Type 3 Open Promoters (Homo sapiens)
REACT:R-XTR-202960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of C-IAP1 (Xenopus tropicalis)
REACT:R-DME-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Drosophila melanogaster)
RHEA:49831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:36433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase => a purine 2'-deoxy-D-ribonucleoside + phosphate
REACT:R-RNO-2162225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)
RHEA:31890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> tirucalladienol
RHEA:54853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptan-4-one + NADPH + O2 => H2O + NADP(+) + propyl butanoate
RHEA:42549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(746) in 23S rRNA => pseudouridine(746) in 23S rRNA
REACT:R-HSA-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Homo sapiens)
RHEA:63201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10bS,4aR)-noroxomaritidine + H(+) + NADPH => (10bS,4aR)-oxomaritidine + NADP(+)
REACT:R-XTR-6808566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHGA-derived peptide binds the bacterial cell surface (Xenopus tropicalis)
RHEA:64187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-tyrosine <=> (9Z)-octadecenoate + L-tyrosine
RHEA:13177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-dehydro-2-deoxyphosphogluconate aldolase"
RHEA:13177	skos:prefLabel	"5-dehydro-2-deoxyphosphogluconate aldolase"
RHEA:13177	skos:altLabel	"phospho-5-keto-2-deoxygluconate aldolase"
RHEA:13177	skos:altLabel	"5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase"
RHEA:13177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + dihydroxyacetone phosphate
RHEA:13177	skos:altLabel	"phospho-5-dehydro-2-deoxygluconate aldolase"
RHEA:16423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:18128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a D-alpha-amino acid + H2O <=> a 2-oxocarboxylate + AH2 + NH4(+)
RHEA:54254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine
RHEA:24370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NH4(+) => L-ornithine
REACT:R-BTA-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Bos taurus)
RHEA:23673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + L-quinate => 3-dehydroquinate + a quinol
REACT:R-HSA-5211224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anthrax cya catalyzes the conversion of ATP to cAMP (Homo sapiens)
REACT:R-SSC-2467794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of sister chromatids (Sus scrofa)
REACT:R-MMU-171106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex => LDLR + LDL (Mus musculus)
REACT:R-DRE-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Danio rerio)
GO:0047390	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycero-3-phosphocholine cholinephosphohydrolase activity
GO:0047390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophosphocholine cholinephosphodiesterase activity
GO:0047390	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-glycerylphosphinicocholine cholinephosphohydrolase activity
REACT:R-DME-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)
GO:0030977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine binding
GO:0102160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity
RHEA:23487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-cellobiose <=> AH2 + D-cellobiono-1,5-lactone
REACT:R-DME-8950724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Drosophila melanogaster)
RHEA:37088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
REACT:R-HSA-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Homo sapiens)
REACT:R-BTA-9029580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Bos taurus)
REACT:R-RNO-5675373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear DUSPs dephosphorylate MAPKs (Rattus norvegicus)
RHEA:37280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-histidine(out) => ADP + H(+) + L-alanyl-L-histidine(in) + phosphate
REACT:R-RNO-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Rattus norvegicus)
RHEA:38874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2457) in 23S rRNA <=> pseudouridine(2457) in 23S rRNA
RHEA:15456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + sarcosine <=> H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine
REACT:R-MMU-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)
REACT:R-DRE-8982641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Danio rerio)
RHEA:48401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]
REACT:R-HSA-265160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin secretory granule translocates to cell cortex (Homo sapiens)
RHEA:34496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
RHEA:23130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoyl-CoA + AMP + diphosphate => 4-hydroxybutanoate + ATP + CoA
REACT:R-CFA-8950181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y693-STAT4 dimer translocates to the nucleus (Canis familiaris)
RHEA:17487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-BTA-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
RHEA:32439	skos:altLabel	"CYP170A1"
RHEA:32439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:32439	skos:prefLabel	"epi-isozizaene 5-monooxygenase"
RHEA:32439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"epi-isozizaene 5-monooxygenase"
EC:2.7.11.12	skos:altLabel	"PKG 1alpha"
EC:2.7.11.12	skos:altLabel	"PKG 1beta"
EC:2.7.11.12	skos:altLabel	"cGMP-dependent protein kinase Ibeta"
EC:2.7.11.12	skos:altLabel	"guanosine 3':5'-cyclic monophosphate-dependent protein kinase"
EC:2.7.11.12	skos:altLabel	"PKG II"
EC:2.7.11.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cGMP-dependent protein kinase"
EC:2.7.11.12	skos:altLabel	"3':5'-cyclic GMP-dependent protein kinase"
EC:2.7.11.12	skos:altLabel	"PKG"
EC:2.7.11.12	skos:prefLabel	"cGMP-dependent protein kinase"
REACT:R-CFA-9696179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Canis familiaris)
REACT:R-XTR-445757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1 receptor antagonist protein binds Interleukin 1 receptors (Xenopus tropicalis)
RHEA:25875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + pyridine <=> H2O + pyridine N-oxide
RHEA:62529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigoxin + 2 Fe(III)-[cytochrome c]
REACT:R-DDI-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Dictyostelium discoideum)
GO:0035888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoguanine deaminase activity
GO:0035888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyadenine deaminase activity
GO:0035888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadenine deaminase activity
REACT:R-DME-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Drosophila melanogaster)
RHEA:46400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]
REACT:R-GGA-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Gallus gallus)
REACT:R-HSA-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Homo sapiens)
REACT:R-PFA-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)
REACT:R-DDI-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Dictyostelium discoideum)
RHEA:20383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + H(+) + NADH => androsterone + NAD(+)
RHEA:19966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S,S-dimethyl-beta-propiothetin => acrylate + dimethyl sulfide + H(+)
RHEA:46355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + H2O <=> 3-hydroxydecanoyl-CoA
RHEA:38495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)
REACT:R-MMU-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Mus musculus)
REACT:R-MMU-83793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Mus musculus)
REACT:R-SSC-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Sus scrofa)
RHEA:24059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a myo-inositol phosphate + H2O <=> myo-inositol + phosphate
REACT:R-XTR-8855111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds PCSK9 (Xenopus tropicalis)
REACT:R-HSA-5617643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA3 mRNA is translated (Homo sapiens)
RHEA:58117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
REACT:R-DME-8981534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin dimer:KIRREL binds FYN (Drosophila melanogaster)
RHEA:34652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Caenorhabditis elegans)
REACT:R-CEL-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Caenorhabditis elegans)
RHEA:58435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-oxonon-2-en-1-ol + NADP(+) <=> (E)-4-oxonon-2-enal + H(+) + NADPH
RHEA:47893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
REACT:R-HSA-2485148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Homo sapiens)
REACT:R-DRE-450550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCalpha phosphorylates HuR (Danio rerio)
RHEA:72681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+) => (R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein]
REACT:R-DRE-2533950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP14, TMPRSS6 (Danio rerio)
REACT:R-SSC-8849348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Sus scrofa)
RHEA:37833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2
REACT:R-DME-6805740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 methylates TP53 (Drosophila melanogaster)
RHEA:43007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-carbamoyl-L-serine <=> 2-aminoprop-2-enoate + CO2 + NH4(+)
RHEA:51671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone
REACT:R-DRE-5684052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates MDC1 (Danio rerio)
REACT:R-DRE-8983335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Danio rerio)
REACT:R-CEL-1234177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
REACT:R-DRE-193780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Danio rerio)
RHEA:67985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-leucine => N-acetyl-D-leucine
REACT:R-DME-109998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Drosophila melanogaster)
RHEA:69465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine => 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:53153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Homo sapiens)
RHEA:42094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase]
GO:0032813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF receptor superfamily binding
GO:0032813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tumor necrosis factor receptor superfamily binding
REACT:R-SSC-173636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of classic pathway C5 convertase (Sus scrofa)
RHEA:19105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminobutyraldehyde dehydrogenase"
RHEA:19105	skos:altLabel	"1-pyrroline dehydrogenase"
RHEA:19105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH
RHEA:19105	skos:altLabel	"gamma-guanidinobutyraldehyde dehydrogenase"
RHEA:19105	skos:altLabel	"ABALDH"
RHEA:19105	skos:altLabel	"4-aminobutanal dehydrogenase"
RHEA:19105	skos:prefLabel	"aminobutyraldehyde dehydrogenase"
RHEA:22809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate + H2O + O2 => 2,6-dihydroxynicotinate + H2O2
REACT:R-BTA-5669012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA binds EDAR (Bos taurus)
RHEA:68945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esculetin + S-adenosyl-L-methionine => H(+) + isoscopoletin + S-adenosyl-L-homocysteine
REACT:R-CFA-5684169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6B binds PTPN6,PTPN11 (Canis familiaris)
RHEA:25562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene + diphosphate => 9alpha-copalyl diphosphate
REACT:R-GGA-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)
RHEA:29419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out)
REACT:R-RNO-9750001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Rattus norvegicus)
REACT:R-MMU-158982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Mus musculus)
RHEA:71316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-serine(out) + 2 Na(+)(out) => chloride(in) + L-serine(in) + 2 Na(+)(in)
REACT:R-SSC-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Sus scrofa)
REACT:R-XTR-2022063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Xenopus tropicalis)
RHEA:36378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamoyl phosphate + H2O <=> carbamoyl adenylate + diphosphate + phosphate
REACT:R-GGA-83788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to Type 2 promoter (Gallus gallus)
RHEA:69632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
REACT:R-CFA-9013108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOC (Canis familiaris)
RHEA:72607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-AMP + CoA = (E)-sinapoyl-CoA + AMP + H(+)
RHEA:60137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate
GO:0030985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK binding
GO:0030985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMW kininogen binding
GO:0030985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high molecular weight kininogen binding
RHEA:35383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6B + S-adenosyl-L-methionine = CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine
REACT:R-BTA-3222128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOC2L binds TP53 (Bos taurus)
REACT:R-PFA-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Plasmodium falciparum)
RHEA:30417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H2O + heptadecane + 2 NADP(+) => H(+) + 2 NADPH + O2 + octadecanal
RHEA:48212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine
REACT:R-HSA-8865244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A homodimer binds CDKN1A (p21) gene (Homo sapiens)
REACT:R-XTR-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Xenopus tropicalis)
RHEA:63410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O => 6-chloropyridine-2,3,5-triol + FADH2 + O2
RHEA:35969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-DDI-3215448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Dictyostelium discoideum)
REACT:R-SSC-3858482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is recruited to the receptor (Sus scrofa)
RHEA:45613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine
REACT:R-XTR-193787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Xenopus tropicalis)
RHEA:13418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,12-dihydroxanthommatin + NAD(+) => H(+) + NADH + xanthommatin
REACT:R-CFA-177941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:GAB1 binds to phosphorylated EGFR (Canis familiaris)
RHEA:65046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cyanobenzaldehyde + H(+) + NADH => 4-cyanobenzyl alcohol + NAD(+)
RHEA:20939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O
RHEA:68930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + heptanal + NADP(+) => ATP + H(+) + heptanoate + NADPH
REACT:R-SSC-174786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Sus scrofa)
RHEA:20218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + trimethylamine N-oxide => dimethylamine + formaldehyde
REACT:R-MMU-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Mus musculus)
REACT:R-BTA-2395818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)
REACT:R-HSA-5223305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL, inhibiting it (Homo sapiens)
REACT:R-HSA-5362427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds GPC5 (Homo sapiens)
RHEA:25251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate + CO2 => H(+) + 2 pyruvate
REACT:R-MMU-177927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)
RHEA:21311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> cycloartenol
REACT:R-BTA-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Bos taurus)
REACT:R-HSA-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Homo sapiens)
REACT:R-SSC-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Sus scrofa)
REACT:R-HSA-8876446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ULK1 phosphorylates DENND3 (Homo sapiens)
RHEA:49965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine + O2 => H2O2 + phenazine
REACT:R-SSC-5250210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Sus scrofa)
REACT:R-RNO-5693602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM recognizes H2AFX-Nucleosomes (Rattus norvegicus)
RHEA:49596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-galactose = H(+) + N-acyl-D-galactosylsphing-4-enine + UDP
REACT:R-HSA-8853956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 (Homo sapiens)
REACT:R-BTA-5654165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR1 (Bos taurus)
REACT:R-GGA-73718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBF-1 Binds rDNA Promoter (Gallus gallus)
RHEA:19760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate
RHEA:64655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaraldehyde + CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH
RHEA:55414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n+1) + GDP => [phosphate](n) + GTP
RHEA:11595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonacolin L-[lovastatin nonaketide synthase] + H2O <=> dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]
RHEA:43818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:56330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O
RHEA:33416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bornane-2,6-dione + H2O => [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)
RHEA:49056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperlicin C + H(+) + NADPH + O2 = asperlicin E + H2O + NADP(+)
REACT:R-BTA-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Bos taurus)
RHEA:41601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
GO:0140337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglyceride transfer activity
GO:0140337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglyceride carrier activity
RHEA:15219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + ecdysone hexadecanoate => ecdysone + hexadecanoyl-CoA
RHEA:11976	skos:prefLabel	"anhydrotetracycline 6-monooxygenase"
RHEA:11976	skos:altLabel	"anhydrotetracycline oxygenase"
RHEA:11976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anhydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrotetracycline + H2O + NADP(+)
RHEA:11976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anhydrotetracycline 6-monooxygenase"
RHEA:11976	skos:altLabel	"anhydrotetracycline monooxygenase"
RHEA:11976	skos:altLabel	"ATC oxygenase"
REACT:R-BTA-3222093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 binds TP53 and EP300 (Bos taurus)
GO:0032030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin I light chain binding
REACT:R-RNO-444731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Rattus norvegicus)
REACT:R-SSC-8851550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside diphosphates (Sus scrofa)
REACT:R-HSA-6811479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 recruits EP300 to TP53 (Homo sapiens)
RHEA:25586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-rhamnose => alpha-L-rhamnose
RHEA:71503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)
GO:0001596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin type I receptor activity
GO:0001596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-activating angiotensin receptor activity
REACT:R-RNO-1535903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Rattus norvegicus)
RHEA:61740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolmonoside + UDP-alpha-D-glucose = H(+) + steviolbioside + UDP
REACT:R-MMU-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Mus musculus)
RHEA:60221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate
REACT:R-DME-9707353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 binds Aromatase inhibitors (Drosophila melanogaster)
REACT:R-RNO-75010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser 216 by Chk1 (Rattus norvegicus)
RHEA:22124	skos:altLabel	"AAE"
RHEA:22124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline
RHEA:22124	skos:altLabel	"2beta(R)-17-O-acetylajmalan:acetylesterase"
RHEA:22124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylajmaline esterase"
RHEA:22124	skos:prefLabel	"acetylajmaline esterase"
RHEA:22124	skos:altLabel	"acetylajmalan esterase"
RHEA:22124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)
REACT:R-BTA-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Bos taurus)
REACT:R-CFA-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Canis familiaris)
REACT:R-SSC-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Sus scrofa)
REACT:R-CEL-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Caenorhabditis elegans)
REACT:R-XTR-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Xenopus tropicalis)
REACT:R-CFA-5669035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF11 binds TNFRSF11A, B (Canis familiaris)
REACT:R-HSA-1834951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFI16 binds cytosolic dsDNA (Homo sapiens)
REACT:R-SPO-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Schizosaccharomyces pombe)
GO:0015518	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arabinose efflux permease activity
GO:0015518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinose:proton symporter activity
GO:0015518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinose:hydrogen symporter activity
GO:0015518	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arabinose efflux transmembrane transporter activity
RHEA:60767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone <=> cinerin II + CoA
REACT:R-DRE-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Danio rerio)
REACT:R-DRE-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Danio rerio)
REACT:R-SCE-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)
REACT:R-MMU-975040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAB-ZNF / KAP Interaction (Mus musculus)
RHEA:45581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactaro-1,5-lactone => D-galactaro-1,4-lactone
RHEA:64531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine
REACT:R-HSA-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Homo sapiens)
RHEA:25550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-8(14),12-diene + diphosphate => (+)-copalyl diphosphate
REACT:R-CEL-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Caenorhabditis elegans)
REACT:R-BTA-5205822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-18 (H3R17) of histone H3 (Bos taurus)
REACT:R-DRE-375790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Danio rerio)
RHEA:71930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauroursodeoxycholate(out) <=> 2 Na(+)(in) + tauroursodeoxycholate(in)
REACT:R-CEL-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Caenorhabditis elegans)
GO:0031127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,2-fucosyltransferase activity
GO:0031127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-(1->2)-fucosyltransferase activity
GO:0031127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-(1,2)-fucosyltransferase activity
GO:0034278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity
GO:0034278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stemar-13-ene synthase activity
REACT:R-HSA-3229152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) (Homo sapiens)
REACT:R-HSA-9033238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
REACT:R-HSA-5672980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF complex (Homo sapiens)
RHEA:43172	skos:altLabel	"18S rRNA methylase Bud23"
RHEA:43172	skos:prefLabel	"18S rRNA (guanine(1575)-N(7))-methyltransferase"
RHEA:43172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine
RHEA:43172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"18S rRNA (guanine(1575)-N(7))-methyltransferase"
REACT:R-CFA-5661517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC comlex binds OTULIN (Canis familiaris)
REACT:R-HSA-1675910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane (Homo sapiens)
RHEA:41418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:63385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine
REACT:R-HSA-5610026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GALK1 does not phosphorylate Gal (Homo sapiens)
RHEA:12087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + NAD(+) <=> D-fructose + H(+) + NADH
REACT:R-CEL-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)
REACT:R-XTR-1592398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP8 (Xenopus tropicalis)
RHEA:57937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopyridoxal + NAD(+) => 5-pyridoxate + 2 H(+) + NADH
RHEA:51061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androst-1-ene-3,17-dione + A => AH2 + androsta-1,4-diene-3,17-dione
EC:3.4.22.70	skos:prefLabel	"sortase A"
EC:3.4.22.70	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sortase A"
RHEA:25668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-pinene + diphosphate => (2E)-geranyl diphosphate
REACT:R-SSC-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Sus scrofa)
GO:0050349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triacetate-lactonase activity
GO:0050349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TAL hydrolase activity
GO:0050349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacetate lactone hydrolase activity
GO:0050349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacetic lactone hydrolase activity
GO:0050349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacetolactone lactonohydrolase activity
GO:0050349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacetic acid lactone hydrolase activity
REACT:R-HSA-5628899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the TIGAR gene (Homo sapiens)
RHEA:37465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate
REACT:R-GGA-6799777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind PPP1R13B or TP53BP2 (Gallus gallus)
REACT:R-CFA-5250209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP binds SLC25A4 (Canis familiaris)
RHEA:55855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA
RHEA:42438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate 6-phosphate(in) + L-histidyl-[protein] => L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein]
REACT:R-SSC-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Sus scrofa)
REACT:R-XTR-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Xenopus tropicalis)
REACT:R-BTA-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Bos taurus)
REACT:R-MMU-2327746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 aggregation (Mus musculus)
RHEA:13778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate + NH4(+) => 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate
EC:1.1.1.50	skos:prefLabel	"3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)"
EC:1.1.1.50	skos:altLabel	"3alpha-hydroxysteroid 3-dehydrogenase (B-specific)"
EC:1.1.1.50	skos:altLabel	"hydroxyprostaglandin dehydrogenase"
EC:1.1.1.50	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)"
EC:1.1.1.50	skos:altLabel	"3alpha-hydroxysteroid dehydrogenase (B-specific)"
EC:1.1.1.50	skos:altLabel	"3alpha-HSD"
RHEA:42981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine => 2-aminoprop-2-enoate + phenol
RHEA:49912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)
GO:0103006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxystearate hydroxylase activity
REACT:R-XTR-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Xenopus tropicalis)
RHEA:15021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + L-quinate = 4-O-feruloyl-D-quinate + CoA
RHEA:15021	skos:prefLabel	"quinate O-hydroxycinnamoyltransferase"
RHEA:15021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinate O-hydroxycinnamoyltransferase"
RHEA:15021	skos:altLabel	"hydroxycinnamoyl coenzyme A-quinate transferase"
RHEA:22899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)
GO:0008408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5' exonuclease activity
GO:0008408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral DNA cleavage by TREX1 (Homo sapiens)
GO:0008408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5'-exonuclease activity
REACT:R-HSA-749446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Homo sapiens)
RHEA:14540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O <=> 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)
REACT:R-MMU-109700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT2 binds PIP3 (Mus musculus)
REACT:R-CEL-176585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Caenorhabditis elegans)
REACT:R-MMU-2028629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Mus musculus)
RHEA:69777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ylangene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-HSA-1454822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP1,2,8,13, PRSS2 (Homo sapiens)
REACT:R-CEL-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Caenorhabditis elegans)
RHEA:18337	skos:prefLabel	"pseudouridylate synthase"
RHEA:18337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + uracil = H2O + psi-UMP
RHEA:18337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudouridylate synthase"
RHEA:18337	skos:altLabel	"uracil hydrolyase"
RHEA:18337	skos:altLabel	"pseudouridine-5'-phosphate glycosidase"
RHEA:18337	skos:altLabel	"pseudouridine synthase"
REACT:R-SPO-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Schizosaccharomyces pombe)
RHEA:36449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycyl-L-proline(in) + H(+) + phosphate => ATP + glycyl-L-proline(out) + H2O
RHEA:39094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenedioyl-CoA + H2O <=> (3S)-hydroxydecanedioyl-CoA
REACT:R-CFA-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Canis familiaris)
GO:0008804	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CKase activity
GO:0008804	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamyl phosphokinase activity
GO:0008804	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl phosphokinase activity
GO:0008804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamate kinase activity
GO:0008804	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:carbamate phosphotransferase activity
REACT:R-DRE-5687101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 phosphorylates FOXO3 (Danio rerio)
RHEA:53330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2,3-diacyl-alpha-D-glucosamine
RHEA:22081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + quinolin-2-ol => H2O + NAD(+) + quinoline-2,8-diol
REACT:R-MMU-2730864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TRAF6 to CBM complex by binding to MALT1 (Mus musculus)
REACT:R-SSC-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Sus scrofa)
GO:0018508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
GO:0018508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate cis-diol dehydrogenase activity
GO:0016752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapoyltransferase activity
REACT:R-XTR-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Xenopus tropicalis)
REACT:R-BTA-1497853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Bos taurus)
GO:0016878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acid-thiol ligase activity
REACT:R-SSC-5686625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAIR1 binds collagen (Sus scrofa)
RHEA:43306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer
RHEA:12798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + scopolamine + succinate
REACT:R-DDI-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Dictyostelium discoideum)
REACT:R-HSA-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Homo sapiens)
REACT:R-SCE-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Saccharomyces cerevisiae)
RHEA:15567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + an L-alpha-amino acid => an N-acyl-L-amino acid + H2O
REACT:R-BTA-5627072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds GOPC:CFTR (Bos taurus)
RHEA:28681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + ubiquinol-8 => 3-demethylubiquinol-8 + S-adenosyl-L-methionine
REACT:R-MMU-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Mus musculus)
RHEA:54320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SSC-9634169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 and NDC1 bind the Nup93 complex (Sus scrofa)
REACT:R-RNO-6805620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A and PML bind TP53 (Rattus norvegicus)
RHEA:11415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymethyl-7,8-dihydropterin + ATP <=> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)
REACT:R-BTA-5653886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1 binds LALBA (Bos taurus)
REACT:R-DME-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Drosophila melanogaster)
REACT:R-RNO-2995376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Rattus norvegicus)
REACT:R-BTA-9638075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from DS (Bos taurus)
REACT:R-SSC-2530429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of soluble VTN:C5b-C9  (Sus scrofa)
REACT:R-RNO-6783556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIFR:JAKs bind gp130:JAKs:CNTFR (Rattus norvegicus)
RHEA:24960	skos:prefLabel	"calcium-regulated photoprotein"
RHEA:24960	skos:altLabel	"calcium-activated photoprotein"
RHEA:24960	skos:altLabel	"mitrocomin"
RHEA:24960	skos:altLabel	"clytin"
RHEA:24960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 = [excited state blue fluorescent protein] + CO2
RHEA:24960	skos:altLabel	"Ca(2+)-regulated photoprotein"
RHEA:24960	skos:altLabel	"aequorin"
RHEA:24960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"calcium-regulated photoprotein"
RHEA:24960	skos:altLabel	"obelin"
RHEA:24960	skos:altLabel	"halistaurin"
RHEA:24960	skos:altLabel	"vialidin"
RHEA:24960	skos:altLabel	"mnemiopsin"
RHEA:24960	skos:altLabel	"berovin"
RHEA:72546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) <=> 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)
REACT:R-RNO-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Rattus norvegicus)
RHEA:35995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-6802938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibitors bind and inhibit highly active BRAF mutants (Homo sapiens)
RHEA:53976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
RHEA:18085	skos:altLabel	"CoB--CoM heterodisulfide reductase"
RHEA:18085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + methanophenazine = coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine
RHEA:18085	skos:prefLabel	"dihydromethanophenazine:CoB--CoM heterodisulfide reductase"
RHEA:18085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydromethanophenazine:CoB--CoM heterodisulfide reductase"
RHEA:18085	skos:altLabel	"heterodisulfide reductase"
REACT:R-HSA-9635892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF4 binds the ATF3 gene (Homo sapiens)
REACT:R-DME-209255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP (Drosophila melanogaster)
REACT:R-GGA-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)
RHEA:71790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + O2 <=> (R)-2-hydroxyglutarate + CO2
REACT:R-BTA-5618110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Bos taurus)
RHEA:58118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose
REACT:R-HSA-168921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)
REACT:R-MMU-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Mus musculus)
REACT:R-CFA-5686073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-3Y-SHC1 (Canis familiaris)
REACT:R-RNO-8865994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds PTPN11 (Rattus norvegicus)
GO:0003774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal motor activity
GO:0003774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
GO:0003774	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	motor activity
RHEA:56115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)
REACT:R-PFA-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Plasmodium falciparum)
REACT:R-HSA-9031527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of APOC2 regulated by NR1H2 or NR1H3 (Homo sapiens)
REACT:R-MMU-191422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate-5-phosphate is further phosphorylated. (Mus musculus)
RHEA:34867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + thiophene-2-carboxylate = AMP + diphosphate + thiophene-2-carbonyl-CoA
REACT:R-HSA-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Homo sapiens)
REACT:R-PFA-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Plasmodium falciparum)
RHEA:61769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside A + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP
REACT:R-CFA-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Canis familiaris)
RHEA:34612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose => H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP
RHEA:59189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine => D-histidine
REACT:R-DRE-2161961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EET(1) is hydrolysed to DHET(1) by EPHX2 (Danio rerio)
RHEA:62420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (R)-2-hydroxy fatty acid + O2 = a fatty acid + CO2 + H2O
GO:0004573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimming glucosidase I
GO:0004573	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosyl-oligosaccharide glucohydrolase activity
GO:0004573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity
GO:0004573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity
GO:0004573	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	processing A-glucosidase I activity
GO:0004573	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosyl-oligosaccharide glucosidase activity
RHEA:28331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ITP => H(+) + IDP + phosphate
REACT:R-SSC-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Sus scrofa)
REACT:R-DRE-5607737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 oligomerizes (Danio rerio)
REACT:R-PFA-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Plasmodium falciparum)
RHEA:40104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propanoyl-CoA => CoA + H(+) + propanoate
REACT:R-HSA-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Homo sapiens)
RHEA:16187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + 2 H(+) + NADH => an aldehyde + H2O + NAD(+)
RHEA:24969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => H2O + 2 oxidized [adrenodoxin] + secalciferol
EC:1.14.13.224	skos:prefLabel	"violacein synthase"
EC:1.14.13.224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"violacein synthase"
EC:1.14.13.224	skos:altLabel	"proviolaceinate monooxygenase"
REACT:R-HSA-173512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Homo sapiens)
REACT:R-HSA-2972956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter (Homo sapiens)
REACT:R-DME-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Drosophila melanogaster)
REACT:R-XTR-2161959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Xenopus tropicalis)
RHEA:32513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O
REACT:R-CFA-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Canis familiaris)
REACT:R-GGA-373147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate + FAD <=> fumarate + FADH2 (Gallus gallus)
REACT:R-DRE-8956099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Danio rerio)
RHEA:40015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O = 13-epi-manool + diphosphate
REACT:R-XTR-5250930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH recruits histone acetyltransferases (Xenopus tropicalis)
REACT:R-DME-5671702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP1G2 binds HGS and CHMP2A (Drosophila melanogaster)
RHEA:27305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloro-L-tryptophan + O2 <=> 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2
RHEA:48039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + H2O <=> globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine
RHEA:51535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + urate <=> 5-hydroxyisourate + H2O + NADP(+)
REACT:R-CFA-450333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Canis familiaris)
RHEA:19805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate
RHEA:24552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH
RHEA:18699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + CO2 => 3-(4-hydroxyphenyl)pyruvate + H(+)
RHEA:50556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D2 = H2O + prostaglandin J2
REACT:R-DME-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Drosophila melanogaster)
REACT:R-CFA-4551738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO2,3 (Canis familiaris)
REACT:R-GGA-388832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds CD28 (Gallus gallus)
REACT:R-SSC-391375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Sus scrofa)
RHEA:19765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol = 3-hydroxypropanal + H2O
RHEA:19765	skos:prefLabel	"glycerol dehydratase"
RHEA:19765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol dehydratase"
RHEA:49279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + phytyl phosphate <=> CDP + phytyl diphosphate
REACT:R-MMU-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Mus musculus)
REACT:R-SSC-2028670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Sus scrofa)
RHEA:34178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-CoA + malonyl-CoA <=> 4-hydroxycoumarin + CO2 + 2 CoA
REACT:R-SSC-5686900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 recruits DCLRE1C to ATM (Sus scrofa)
RHEA:18820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + malonate <=> acetate + malonyl-CoA
REACT:R-CEL-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Caenorhabditis elegans)
RHEA:49330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene
REACT:R-HSA-6806413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the MLH1 gene (Homo sapiens)
GO:0140351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosylceramide flippase activity
GO:0140351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glucosylceramide flippase activity
GO:0140351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	galactosylceramide flippase activity
GO:0140351	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	galactocerebroside flippase activity
GO:0140351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoceramide flippase activity
GO:0140351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosylceramide flippase activity (exoplasmic to cytosolic leaftlet)
REACT:R-CEL-164840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP and Pi bind to ATPase (Caenorhabditis elegans)
REACT:R-XTR-8855747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Xenopus tropicalis)
REACT:R-DME-70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Drosophila melanogaster)
RHEA:41467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-192051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7A1 7-hydroxylates CHOL (Danio rerio)
RHEA:58681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + FADH2 => AH2 + FAD + H(+)
REACT:R-SCE-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Saccharomyces cerevisiae)
REACT:R-DRE-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Danio rerio)
RHEA:33766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-CoA + H(+) + NADPH <=> a 2,3-saturated acyl-CoA + NADP(+)
REACT:R-CEL-77615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR2) (Caenorhabditis elegans)
REACT:R-BTA-8856223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Bos taurus)
EC:1.4.3.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-aspartate oxidase"
EC:1.4.3.1	skos:altLabel	"aspartic oxidase"
EC:1.4.3.1	skos:prefLabel	"D-aspartate oxidase"
REACT:R-CFA-5357780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)
REACT:R-MMU-9670673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIX is secreted (Mus musculus)
RHEA:13084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin amide + H2O <=> biotin + NH4(+)
REACT:R-BTA-5626681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of transition zone proteins (Bos taurus)
REACT:R-DME-391935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP1 receptor can bind PGD2 (Drosophila melanogaster)
REACT:R-BTA-8854071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome-mediated degradation of PolyUb-FBXL7 (Bos taurus)
REACT:R-BTA-8851908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 (Bos taurus)
RHEA:41499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
RHEA:40088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-hydroxydocosanoate + NAD(+) => 22-oxodocosanoate + H(+) + NADH
RHEA:69970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) <=> Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)
RHEA:43325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
REACT:R-HSA-2206299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective IDUA does not hydrolyse Heparan sulfate chain(6) (Homo sapiens)
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylylsulfate kinase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine phosphosulfokinase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylylsulfate kinase (phosphorylating)
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine 5'-phosphosulfate kinase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine-5'-phosphosulfate 3'-phosphotransferase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-phosphoadenosine sulfate kinase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APS kinase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine-5'-phosphosulphate 3'-phosphotransferase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-sulfate kinase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine phosphosulfate kinase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:adenylyl-sulfate 3'-phosphotransferase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-sulphate kinase activity
GO:0004020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine-5'-phosphosulfate-3'-phosphokinase activity
REACT:R-HSA-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Homo sapiens)
REACT:R-MMU-5689973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10,USP24,USP42 deubiquitinate TP53 (Mus musculus)
RHEA:17206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate
REACT:R-SSC-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Sus scrofa)
GO:0052599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylputrescine oxidase activity
GO:0052599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylputrescine:oxygen oxidoreductase (deaminating) activity
RHEA:62981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenamide + H2O => (9Z)-hexadecenoate + NH4(+)
RHEA:27899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-AMP + H2O => adenosine + phosphate
RHEA:23069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA => 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)
RHEA:11962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-succinylamino-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate
REACT:R-CFA-2393954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
REACT:R-HSA-8948569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-19b microRNA binds PTEN mRNA (Homo sapiens)
RHEA:70765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine
REACT:R-SSC-176494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to 27HCHOL (Sus scrofa)
REACT:R-CFA-432897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ILK interacts with beta-1 integrin (Canis familiaris)
RHEA:37210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-SSC-8851908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 (Sus scrofa)
REACT:R-XTR-202248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma1 (Xenopus tropicalis)
REACT:R-XTR-9692376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL2 binds BCL2 antagonists (Xenopus tropicalis)
REACT:R-MMU-936991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Mus musculus)
RHEA:42651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2,5-ethylene furandicarboxylate)(n) + 2 H2O <=> (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)
RHEA:41979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) <=> CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)
REACT:R-MMU-9614423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO1 (Mus musculus)
REACT:R-GGA-426209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG activation of TRPC channels (Gallus gallus)
GO:0019159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide-nucleotide amidase activity
GO:0019159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide-D-ribonucleotide amidohydrolase activity
GO:0019159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NMN deamidase activity
GO:0019159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide mononucleotide amidohydrolase activity
GO:0019159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NMN amidohydrolase
GO:0019159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide mononucleotide deamidase activity
RHEA:67870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]
REACT:R-MMU-163809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)
REACT:R-CFA-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Canis familiaris)
REACT:R-RNO-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)
REACT:R-CFA-166542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-NGF dimer binds to TrkA receptor (Canis familiaris)
RHEA:65280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)
RHEA:55661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-beta-carotene + 2 O2 => 2 A + echinenone + 3 H2O
REACT:R-DRE-8950518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Danio rerio)
REACT:R-MMU-2022052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Mus musculus)
REACT:R-RNO-8853753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Rattus norvegicus)
RHEA:16212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-8X <=> cob(II)yrinate
REACT:R-RNO-74736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Rattus norvegicus)
REACT:R-BTA-5362551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Bos taurus)
REACT:R-CFA-2730861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Canis familiaris)
REACT:R-MMU-9710101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP4, CASP5 cleave GSDMD (Mus musculus)
REACT:R-HSA-392752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by CK-II (Homo sapiens)
REACT:R-RNO-419426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cannabinoid receptors can bind cannabinoids (Rattus norvegicus)
REACT:R-MMU-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Mus musculus)
RHEA:37122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine <=> 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)
REACT:R-GGA-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Gallus gallus)
RHEA:44349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide B + H(+) + phosphate
REACT:R-HSA-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Homo sapiens)
EC:2.3.3.16	skos:altLabel	"oxaloacetate transacetase"
EC:2.3.3.16	skos:altLabel	"oxalacetic transacetase"
EC:2.3.3.16	skos:altLabel	"citric synthase"
EC:2.3.3.16	skos:altLabel	"citrate condensing enzyme"
EC:2.3.3.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citrate synthase (unknown stereospecificity)"
EC:2.3.3.16	skos:altLabel	"citrogenase"
EC:2.3.3.16	skos:altLabel	"CoA-acetylating citrate oxaloacetate-lyase"
EC:2.3.3.16	skos:altLabel	"citric-condensing enzyme"
EC:2.3.3.16	skos:altLabel	"condensing enzyme"
EC:2.3.3.16	skos:prefLabel	"citrate synthase (unknown stereospecificity)"
EC:2.3.3.16	skos:altLabel	"citrate synthetase"
RHEA:28562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate
RHEA:48816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
RHEA:27795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 4 diphosphate
REACT:R-SCE-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Saccharomyces cerevisiae)
REACT:R-BTA-9728150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 binds gliflozins (Bos taurus)
RHEA:34824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + curcumin
REACT:R-DME-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Drosophila melanogaster)
REACT:R-DRE-201457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP2 binds to the receptor complex (Danio rerio)
RHEA:21651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prephenate <=> 3-phenylpyruvate + CO2 + H2O
RHEA:33941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-hydroxy-L-arginine + NAD(+) => H(+) + L-arginine + NADH + O2
RHEA:46853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3-one + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-HSA-4093331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras:GTP binds p120-RasGAP (Homo sapiens)
REACT:R-RNO-186798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binds to PDGF-beta receptors only (Rattus norvegicus)
REACT:R-XTR-449829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11 binds IL11RA (Xenopus tropicalis)
RHEA:49057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperlicin C + H(+) + NADPH + O2 => asperlicin E + H2O + NADP(+)
RHEA:72389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(in) + sulfate(out) => 2 hydrogencarbonate(out) + sulfate(in)
REACT:R-HSA-5660479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTF1 dimer:12Zn2+ binds SNCB gene (beta-synuclein) (Homo sapiens)
GO:0008080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyltransferase activity
GO:0008080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842 (Homo sapiens)
RHEA:20864	skos:altLabel	"trehalose 6-phosphate:phosphate beta-D-glucosyltransferase"
RHEA:20864	skos:prefLabel	"trehalose 6-phosphate phosphorylase"
RHEA:20864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trehalose 6-phosphate phosphorylase"
RHEA:20864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + phosphate = beta-D-glucose 1-phosphate + D-glucose 6-phosphate
RHEA:61750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + stevioside + UDP => rubusoside + UDP-alpha-D-glucose
RHEA:50174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2
RHEA:21139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + acetyl-CoA <=> CoA + O-acetyl-(R)-carnitine
RHEA:52248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 H2O + 4 Mn(3+) + O2 = 12 H(+) + 4 MnO2
REACT:R-CEL-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Caenorhabditis elegans)
REACT:R-DRE-390641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA1A,B,D bind ADR,NAd (Danio rerio)
REACT:R-BTA-9010872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 binds Dystroglycan (Bos taurus)
REACT:R-MMU-6786720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DECR2 reduces LCtE-CoA to t3enoyl-CoA (Mus musculus)
RHEA:13607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 L-dehydroascorbate => 2 L-ascorbate + O2
RHEA:29057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + 2 H(+)(out) => a ubiquinone + 2 H(+)(in) + H2
REACT:R-HSA-437243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doublecortin binds phosphorylated neurofascin (Homo sapiens)
RHEA:17927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arabinono-1,4-lactone + NADH => alpha-L-arabinopyanose + NAD(+)
REACT:R-DRE-8858346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMHR2 binds AMH (Danio rerio)
EC:1.1.1.184	skos:altLabel	"NADPH-dependent carbonyl reductase"
EC:1.1.1.184	skos:altLabel	"aldehyde reductase I"
EC:1.1.1.184	skos:altLabel	"prostaglandin 9-ketoreductase"
EC:1.1.1.184	skos:prefLabel	"carbonyl reductase (NADPH)"
EC:1.1.1.184	skos:altLabel	"xenobiotic ketone reductase"
EC:1.1.1.184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carbonyl reductase (NADPH)"
RHEA:51662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+) => an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2
REACT:R-SSC-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Sus scrofa)
REACT:R-DRE-6806732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface (Danio rerio)
RHEA:60212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate
GO:0099094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-gated cation channel activity
REACT:R-DRE-109530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Danio rerio)
RHEA:45688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) = N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)
REACT:R-BTA-209925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIT and MIT combine to form triiodothyronine (Bos taurus)
RHEA:12886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) => GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)
GO:0047030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity
GO:0047030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxycyclohexanecarboxylate dehydrogenase activity
GO:0047030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity
REACT:R-SSC-199032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADCAM1-1 binds Integrin alpha4beta7 (Sus scrofa)
REACT:R-DRE-3814820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Danio rerio)
RHEA:27289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH
REACT:R-XTR-429581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 transports vitamins from extracellular region to cytosol (Xenopus tropicalis)
RHEA:70685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-metanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-normetanephrine + S-adenosyl-L-methionine
RHEA:68749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] => alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]
RHEA:62049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
REACT:R-DDI-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Dictyostelium discoideum)
REACT:R-SSC-2395876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
REACT:R-RNO-398185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG binds plexin B1 (Rattus norvegicus)
REACT:R-SSC-2581474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK1,4,7 phosphorylate MII to p-MII (Sus scrofa)
REACT:R-GGA-9646679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded proteins bind vimentin to form aggresome (Gallus gallus)
REACT:R-GGA-265153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Gallus gallus)
RHEA:67904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + H(+) + malonyl-[ACP] = 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA
RHEA:20701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + lipid A disaccharide (E. coli) => ADP + H(+) + lipid IVA (E. coli)
REACT:R-XTR-5195402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LPIN (Xenopus tropicalis)
REACT:R-DME-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Drosophila melanogaster)
REACT:R-DRE-5649658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves DHU from damaged DNA (Danio rerio)
REACT:R-HSA-74715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of insulin receptor (Homo sapiens)
RHEA:52776	skos:prefLabel	"camalexin synthase"
RHEA:52776	skos:altLabel	"CYP71B15"
RHEA:52776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"camalexin synthase"
RHEA:52776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:52776	skos:altLabel	"bifunctional dihydrocamalexate synthase/camalexin synthase"
REACT:R-CFA-210285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homophilic interaction of PECAM-1 (Canis familiaris)
RHEA:10263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mg(2+)(out) <=> ADP + H(+) + Mg(2+)(in) + phosphate
REACT:R-CFA-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Canis familiaris)
REACT:R-DDI-9755306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub UBXN7 is degraded by the 26S proteasome (Dictyostelium discoideum)
RHEA:56705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate
RHEA:50375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphingoid base 1-phosphate(in) <=> an N-acylsphingoid base 1-phosphate(out)
EC:3.4.23.32	skos:prefLabel	"scytalidopepsin B"
EC:3.4.23.32	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scytalidopepsin B"
EC:3.4.23.32	skos:altLabel	"Scytalidium aspartic proteinase B"
REACT:R-MMU-936986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)
RHEA:50213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate
RHEA:58145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + cytidine(34) in elongator tRNA(Met) => AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)
RHEA:31093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanoyl-CoA + CoA => acetyl-CoA + dodecanoyl-CoA
RHEA:55410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n+1) + CDP => [phosphate](n) + CTP
REACT:R-SSC-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Sus scrofa)
GO:0102926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solanidine glucosyltransferase activity
REACT:R-GGA-5607744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 binds BCL10 (Gallus gallus)
REACT:R-DME-8849345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Drosophila melanogaster)
REACT:R-GGA-419223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)
RHEA:59572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-homocarnosine = 4-aminobutanoate + L-histidine
RHEA:61911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol <=> 2 AMP + asperphenamate + 2 diphosphate + H(+)
RHEA:58901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-carboxybiuret + H2O => NH4(+) + urea-1,3-dicarboxylate
GO:0102618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oryzalexin B synthase activity
REACT:R-MMU-444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR5 binds CXCL13 (Mus musculus)
REACT:R-SSC-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Sus scrofa)
RHEA:48108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine
RHEA:48108	skos:prefLabel	"type II protein arginine methyltransferase"
RHEA:48108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"type II protein arginine methyltransferase"
REACT:R-HSA-5625796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM4C binds KLK2 and KLK3 promoters (Homo sapiens)
REACT:R-RNO-8984012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Rattus norvegicus)
REACT:R-CEL-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Caenorhabditis elegans)
RHEA:55659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + a carotenoid beta-end derivative <=> a carotenoid chi-end derivative + 2 AH2
REACT:R-MMU-6804879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates TP53 (Mus musculus)
RHEA:66794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-D-dopa + O2
REACT:R-HSA-2464810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL(membrane) diffuses to atRAL(cytosol) (Homo sapiens)
EC:1.13.11.92	skos:prefLabel	"fatty acid alpha-dioxygenase"
EC:1.13.11.92	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty acid alpha-dioxygenase"
GO:0004723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
GO:0004723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent protein serine/threonine phosphatase activity
GO:0004723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity
GO:0004723	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcineurin
GO:0102868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-epi-campsterol desaturase activity
REACT:R-DME-9620456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sGC stimulators bind sGC:NO (Drosophila melanogaster)
RHEA:69168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + spermine monoaldehyde = 2 H(+) + N-(2-carboxyethyl)spermidine + NADH
REACT:R-SSC-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Sus scrofa)
REACT:R-HSA-8876472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 binds CHOL (Homo sapiens)
REACT:R-SSC-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Sus scrofa)
REACT:R-HSA-9685639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching (Homo sapiens)
REACT:R-HSA-8933292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LSR trimer binds VLDL (Homo sapiens)
RHEA:39913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-2-oxo-3-phenylbutanoate + L-glutamate => (2S,3S)-3-methylphenylalanine + 2-oxoglutarate
REACT:R-CFA-2454192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Allergen dependent IgE bound FCERI aggregation (Canis familiaris)
RHEA:64203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-leucine + H2O <=> a fatty acid + L-leucine
RHEA:13989	skos:prefLabel	"UDP-glucose--hexose-1-phosphate uridylyltransferase"
RHEA:13989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
RHEA:13989	skos:altLabel	"galactose-1-phosphate uridylyltransferase"
RHEA:13989	skos:altLabel	"uridyl transferase"
RHEA:13989	skos:altLabel	"hexose-1-phosphate uridylyltransferase"
RHEA:13989	skos:altLabel	"uridylyl removing enzyme"
RHEA:13989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-glucose--hexose-1-phosphate uridylyltransferase"
RHEA:13989	skos:altLabel	"Gal-1-P uridylyltransferase"
RHEA:59191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine <=> D-histidine
REACT:R-RNO-921155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from the receptor complex (Rattus norvegicus)
RHEA:39028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP
REACT:R-RNO-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Rattus norvegicus)
REACT:R-MMU-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Mus musculus)
REACT:R-BTA-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Bos taurus)
REACT:R-SSC-5666216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds TAX1BP3 (Sus scrofa)
REACT:R-XTR-2318623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan binds Hyaluronan and HAPLN1 (Xenopus tropicalis)
REACT:R-GGA-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Gallus gallus)
RHEA:61219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)
EC:3.2.1.72	skos:prefLabel	"xylan 1,3-beta-xylosidase"
EC:3.2.1.72	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylan 1,3-beta-xylosidase"
EC:3.2.1.72	skos:altLabel	"exo-1,3-beta-xylosidase"
RHEA:29847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA
REACT:R-CEL-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Caenorhabditis elegans)
RHEA:22757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + O2 => a long-chain fatty aldehyde + H2O2
REACT:R-HSA-168910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP1 facilitates IKK complex phosphorylation (Homo sapiens)
REACT:R-RNO-448673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of caspase-1 p10/p20 dimer (Rattus norvegicus)
RHEA:17562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine + H2O => acetate + choline + H(+)
RHEA:50462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty acyl-[ACP] + AMP + diphosphate => a medium chain fatty acid + ATP + holo-[ACP]
RHEA:54432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate
RHEA:43234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isatinate => H2O + isatin
RHEA:12524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADPH
GO:0008984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-L-glutamate-5-O-methyl-ester acylhydrolase activity
GO:0008984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glutamate methylesterase activity
GO:0008984	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methyl-accepting chemotaxis protein methyl-esterase activity
GO:0008984	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CheB methylesterase activity
GO:0008984	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	chemotaxis-specific methylesterase activity
GO:0008984	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methylesterase CheB activity
GO:0008984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-L-glutamate-O5-methyl-ester acylhydrolase activity
REACT:R-RNO-4656914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKBIA with SUMO1 (Rattus norvegicus)
RHEA:46451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-tyrosyl-tRNA(Tyr) <=> cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)
RHEA:10872	skos:prefLabel	"aspartoacylase"
RHEA:10872	skos:altLabel	"aminoacylase II"
RHEA:10872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate
RHEA:10872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartoacylase"
REACT:R-BTA-3234094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TFAP2C with SUMO1 (Bos taurus)
GO:0017089	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane glycolipid transfer activity
GO:0017089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolipid transfer activity
GO:0017089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolipid carrier activity
GO:0017089	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane glycolipid transporter activity
GO:0017089	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycolipid transporter activity
GO:0017089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rv1410c transports lprG:LM,LAM from cytosol to the cell wall (Homo sapiens)
GO:0017089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTP transports GSL from plasma membrane to ER membrane (Homo sapiens)
RHEA:28317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baicalein + UDP-alpha-D-glucuronate <=> baicalin + UDP
RHEA:22208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)
REACT:R-RNO-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Rattus norvegicus)
REACT:R-MMU-174374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 from MeCbl to HCYS (Mus musculus)
REACT:R-CEL-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Caenorhabditis elegans)
RHEA:42420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysine + O2 = (4R)-4-hydroxy-L-lysine + CO2 + succinate
REACT:R-DME-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Drosophila melanogaster)
RHEA:67640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dZMP = ADP + dZDP
REACT:R-MMU-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Mus musculus)
RHEA:30137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + dodecanoate + H(+) => dodecanoyl-CoA + H2O
RHEA:61410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine => ATP + N(6)-(D-erythrulosyl)-L-lysine
REACT:R-DRE-197250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAMPT transfers PRIB to NAM to form NAMN (Danio rerio)
RHEA:66375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 3-phosphate <=> glycerol + phosphate
RHEA:10158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:30740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + H2O => myo-inositol + phosphate
REACT:R-HSA-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-DRE-6811454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate PP2A (Danio rerio)
REACT:R-CFA-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Canis familiaris)
REACT:R-CFA-373086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR10 binds CCL27 and 28 ligands (Canis familiaris)
REACT:R-SCE-390250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Saccharomyces cerevisiae)
GO:0050319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R,R)-tartrate carboxy-lyase (D-glycerate-forming)
GO:0050319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R,R)-tartrate carboxy-lyase activity
GO:0050319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tartrate decarboxylase activity
REACT:R-RNO-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)
REACT:R-DME-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Drosophila melanogaster)
RHEA:47858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD1a (d18:1(4E)) + H2O
GO:0034830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity
REACT:R-HSA-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Homo sapiens)
REACT:R-HSA-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Homo sapiens)
RHEA:28005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone
REACT:R-RNO-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Rattus norvegicus)
REACT:R-SSC-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Sus scrofa)
REACT:R-HSA-1638821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
GO:0070635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-ribosylnicotinamide hydrolase activity
GO:0070635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide riboside hydrolase activity
GO:0070635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide ribonucleoside hydrolase activity
RHEA:52169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Dictyostelium discoideum)
REACT:R-HSA-8867135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEACAM1,3,5,6 bind opa proteins (Homo sapiens)
GO:0035242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein arginine omega-N asymmetric methyltransferase activity
GO:0035242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type I protein arginine methyltransferase activity
GO:0035242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming)
GO:0035242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type I PRMT activity
GO:0035242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein arginine omega-N asymmetric methylase activity
GO:0035242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine omega-N asymmetric methyltransferase activity
REACT:R-DDI-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Dictyostelium discoideum)
RHEA:30384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-7-epi-alpha-selinene + diphosphate
REACT:R-HSA-8864453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1 (Homo sapiens)
REACT:R-BTA-8865613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Bos taurus)
REACT:R-HSA-5610720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI3 (Homo sapiens)
REACT:R-DRE-2426259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Danio rerio)
REACT:R-DME-8953418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 complex binds E2F6.com-1 core (Drosophila melanogaster)
RHEA:52560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-erythronate = 3-dehydro-D-erythronate
RHEA:52560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-L-erythronate = 3-dehydro-L-erythronate
RHEA:52560	skos:prefLabel	"2-dehydrotetronate isomerase"
RHEA:52560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydrotetronate isomerase"
REACT:R-XTR-2213210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen IX is cross-linked to the surface of collagen type II fibrils (Xenopus tropicalis)
RHEA:67848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate
RHEA:12903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ornithine + urea => D-arginine + H2O
REACT:R-CFA-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Canis familiaris)
REACT:R-DRE-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Danio rerio)
REACT:R-SSC-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Sus scrofa)
RHEA:70280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + stachyose => D-galactose + raffinose
REACT:R-DRE-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Danio rerio)
REACT:R-CEL-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Caenorhabditis elegans)
RHEA:43287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate
REACT:R-CFA-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Canis familiaris)
RHEA:16148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-193703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta is activated (Homo sapiens)
RHEA:66987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + H2O <=> CoA + H(+) + isovalerate
GO:0015667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA[cytosine-N4]methyltransferase activity
GO:0015667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(4)-cytosine-specific DNA methylase activity
GO:0015667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	site-specific DNA-methyltransferase (cytosine-N4-specific) activity
GO:0015667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	restriction-modification system activity
GO:0015667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity
GO:0015667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	modification methylase activity
GO:0015667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N4-cytosine-specific DNA methylase activity
GO:0015667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	m4C-forming MTase activity
GO:0015667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity
REACT:R-DDI-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Dictyostelium discoideum)
REACT:R-GGA-83586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Gallus gallus)
RHEA:33341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoyl-CoA
RHEA:18979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + dihydroxyacetone phosphate => a quinone + sn-glycerol 3-phosphate
GO:0045520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-24 receptor binding
GO:0045520	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-24 receptor ligand
GO:0045520	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-24
REACT:R-SSC-1855171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Sus scrofa)
GO:0102875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity
RHEA:62982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + NH4(+) => (9Z)-hexadecenamide + H2O
REACT:R-PFA-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Plasmodium falciparum)
RHEA:35014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fucose(in) + H(+)(in) <=> D-fucose(out) + H(+)(out)
RHEA:18784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA <=> acetyl-CoA + CO2
REACT:R-BTA-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Bos taurus)
REACT:R-CFA-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Canis familiaris)
REACT:R-SPO-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Schizosaccharomyces pombe)
REACT:R-DRE-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Danio rerio)
REACT:R-BTA-211190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of DFF45 (117) (Bos taurus)
RHEA:12159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH
REACT:R-BTA-71825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Bos taurus)
REACT:R-HSA-5653840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
REACT:R-SSC-8950423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Sus scrofa)
GO:0019972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-12 binding
GO:0019972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-12 binding
REACT:R-DRE-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Danio rerio)
GO:0047631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPR-PPase activity
GO:0047631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-ribose ribophosphohydrolase activity
GO:0047631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-ribose phosphohydrolase activity
GO:0047631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADPribose pyrophosphatase activity
GO:0047631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-ribose pyrophosphatase activity
GO:0047631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-ribose diphosphatase activity
GO:0047631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine diphosphoribose pyrophosphatase activity
GO:0047631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADPribose diphosphatase activity
REACT:R-DDI-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Dictyostelium discoideum)
RHEA:27352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate + mycothiol <=> arseno-mycothiol + H2O
GO:0047233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity
GO:0047233	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity
GO:0047233	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity
GO:0018601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-nitrophenol hydroxylase activity
GO:0018601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)
GO:0018601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol 2-monooxygenase activity
GO:0018601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-nitrophenol-2-hydroxylase activity
REACT:R-HSA-9011074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHX2 binds to ROBO1 gene locus (Homo sapiens)
RHEA:20062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + a ribonucleoside 5'-triphosphate => a ribonucleoside 5'-diphosphate + dCMP + H(+)
RHEA:19811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + glyoxylate + 2 NH4(+) => (S)-ureidoglycolate + 2 H(+) + H2O
REACT:R-BTA-199050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Bos taurus)
REACT:R-CFA-8940388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPLD1 hydrolyses GPI-anchors from proteins (Canis familiaris)
GO:0018832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	halohydrin hydrogen-halide-lyase B activity
RHEA:41752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)
REACT:R-DRE-9656891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1SW binds 11cRAL (Danio rerio)
REACT:R-RNO-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Rattus norvegicus)
REACT:R-SSC-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Sus scrofa)
REACT:R-XTR-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Xenopus tropicalis)
RHEA:20613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine = adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine
REACT:R-MMU-8983870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Mus musculus)
REACT:R-MMU-110375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Mus musculus)
GO:0004638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphoribosyl-5-aminoimidazole carboxylase activity
GO:0004638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
GO:0004638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity
GO:0004638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity
GO:0004638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosylaminoimidazole carboxylase activity
GO:0004638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	class II PurE
GO:0004638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AIR carboxylase activity
GO:0004638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-amino-1-ribosylimidazole 5-phosphate carboxylase activity
GO:0004638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADE2
GO:0031819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 nucleotide receptor binding
GO:0031819	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P2Y10 nucleotide receptor ligand
REACT:R-BTA-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)
RHEA:10822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythro-isocitrate => D-threo-isocitrate
REACT:R-XTR-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Xenopus tropicalis)
REACT:R-XTR-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Xenopus tropicalis)
REACT:R-BTA-6799466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 dimerizes (Bos taurus)
REACT:R-HSA-976991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
EC:1.1.1.323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-thujan-3-ol dehydrogenase"
EC:1.1.1.323	skos:altLabel	"D-3-thujanol dehydrogenase"
EC:1.1.1.323	skos:prefLabel	"(+)-thujan-3-ol dehydrogenase"
REACT:R-HSA-8982163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)
REACT:R-HSA-2032800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of NPPA (ANF) (Homo sapiens)
RHEA:45007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 2,6-dimethylheptanoyl-CoA <=> CoA + O-2,6-dimethylheptanoyl-(R)-carnitine
RHEA:26351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactose + phosphate => beta-L-galactose 1-phosphate + H2O
GO:0010209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vacuolar sorting signal binding
RHEA:71864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurodeoxycholate(out) => taurodeoxycholate(in)
REACT:R-MMU-8871376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds PI3P (Mus musculus)
REACT:R-GGA-9624778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD 12mer translocates from ER membrane to extracellular region (Gallus gallus)
GO:0052830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Homo sapiens)
GO:0052830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
REACT:R-MMU-164617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of Extended Telomeric Chromosome End (Mus musculus)
REACT:R-MMU-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Mus musculus)
RHEA:11673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate
RHEA:56505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-SSC-873927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of STAT1 dimer from active receptor unit (Sus scrofa)
RHEA:10682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-proline => L-proline
RHEA:27547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + FADH2 + O2 => 3-hydroxyanthranilate + FAD + H(+) + H2O
REACT:R-SSC-9701507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN6 dephosphorylates JAK3 (Sus scrofa)
RHEA:17011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-succinylbenzoyl-CoA + AMP + diphosphate => 2-succinylbenzoate + ATP + CoA
REACT:R-CEL-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Caenorhabditis elegans)
REACT:R-HSA-352182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Homo sapiens)
REACT:R-BTA-9708104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE5A dimer binds PDE5A inhibitors (Bos taurus)
REACT:R-DME-443910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 dissociates from integrin alphaIIb beta3 (Drosophila melanogaster)
REACT:R-SSC-9678935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Sus scrofa)
REACT:R-SSC-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Sus scrofa)
REACT:R-DRE-9634169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 and NDC1 bind the Nup93 complex (Danio rerio)
REACT:R-HSA-9626235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8 dissociates from LAMP2a (Homo sapiens)
REACT:R-XTR-8864029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Xenopus tropicalis)
REACT:R-DRE-400682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Rac1 interacts with Plexin-B1:Sema4D (Danio rerio)
EC:3.4.21.53	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endopeptidase La"
EC:3.4.21.53	skos:altLabel	"ATP-dependent protease La"
EC:3.4.21.53	skos:altLabel	"ATP-dependent serine proteinase"
EC:3.4.21.53	skos:prefLabel	"endopeptidase La"
REACT:R-HSA-6785438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC) (Homo sapiens)
REACT:R-CFA-983285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B binds RAD51C (Canis familiaris)
RHEA:41464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:41464	skos:altLabel	"CYP701A"
RHEA:41464	skos:prefLabel	"ent-sandaracopimaradiene 3-hydroxylase"
RHEA:41464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-sandaracopimaradiene 3-hydroxylase"
REACT:R-CEL-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Caenorhabditis elegans)
RHEA:70163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + methotrexate(in) = H(+)(out) + methotrexate(out)
REACT:R-MMU-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Mus musculus)
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gelonin
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribosomal ribonucleate N-glycosidase activity
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA N-glycosylase activity
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA N-glycosidase activity
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	saporins
GO:0030598	skos:prefLabel	"rRNA N-glycosylase"
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	momorcochin-S
GO:0030598	skos:altLabel	"rRNA N-glycosidase"
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nigrin b
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA N-glycosidase activity
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rRNA N-glycohydrolase activity
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mirabilis antiviral protein
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rRNA N-glycosylase"
GO:0030598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ricin
REACT:R-HSA-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Homo sapiens)
RHEA:13089	skos:altLabel	"cytochrome c nitrite reductase"
RHEA:13089	skos:prefLabel	"nitrite reductase (cytochrome; ammonia-forming)"
RHEA:13089	skos:altLabel	"multiheme nitrite reductase"
RHEA:13089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrite reductase (cytochrome; ammonia-forming)"
RHEA:13089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite
RHEA:13089	skos:altLabel	"cytochrome c552"
REACT:R-GGA-6799695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX5,6 reduce H2O2 to H2O (Gallus gallus)
REACT:R-DME-8957241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP73 tetramer translocates to the nucleus (Drosophila melanogaster)
REACT:R-XTR-429449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk activation leads to SLP-76 activation (Xenopus tropicalis)
REACT:R-DME-5653886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1 binds LALBA (Drosophila melanogaster)
REACT:R-DRE-1912357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH ubiquitinates DTX (Danio rerio)
RHEA:55409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + CTP => [phosphate](n+1) + CDP
RHEA:19198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + NH4(+) => adenosine 5'-phosphoramidate + 2 H(+) + sulfate
REACT:R-DME-170055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)
RHEA:30205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 GDP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate
REACT:R-XTR-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Xenopus tropicalis)
REACT:R-HSA-5655247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants (Homo sapiens)
GO:0010484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3 histone acetyltransferase activity
GO:0010484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3 histone acetylase activity
GO:0010484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3 acetyltransferase activity
RHEA:62496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-arginine = diphosphate + L-arginyl-AMP
GO:0033960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl nucleosidase activity
GO:0033960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-methyl nucleosidase"
GO:0033960	skos:altLabel	"N-methyl nucleoside hydrolase"
GO:0033960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methyl nucleoside hydrolase activity
GO:0033960	skos:altLabel	"N-MeNase"
GO:0033960	skos:altLabel	"7-methylxanthosine nucleosidase"
GO:0033960	skos:prefLabel	"N-methyl nucleosidase"
GO:0033960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-methylxanthosine ribohydrolase activity
GO:0033960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-MeNase activity
GO:0033960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-methylxanthosine nucleosidase activity
GO:0033960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylpurine nucleosidase activity
GO:0033960	skos:altLabel	"methylpurine nucleosidase"
GO:0033960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthosine + H2O = 7-methylxanthine + D-ribose + H(+)
REACT:R-CEL-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Caenorhabditis elegans)
RHEA:19185	skos:altLabel	"hydroxyglutarate synthase"
RHEA:19185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)
RHEA:19185	skos:altLabel	"2-hydroxyglutaratic synthetase"
RHEA:19185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyglutarate synthase"
RHEA:19185	skos:altLabel	"2-hydroxyglutaric synthetase"
RHEA:19185	skos:altLabel	"2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating)"
RHEA:19185	skos:altLabel	"alpha-hydroxyglutarate synthase"
RHEA:19185	skos:prefLabel	"2-hydroxyglutarate synthase"
REACT:R-DRE-5654562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Danio rerio)
REACT:R-BTA-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Bos taurus)
GO:0051032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleic acid transmembrane transporter activity
REACT:R-BTA-6814387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP14 cleaves filaggrin (Bos taurus)
REACT:R-BTA-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Bos taurus)
REACT:R-HSA-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Homo sapiens)
REACT:R-MMU-9749609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCHE hydrolyzes ASA- (Mus musculus)
REACT:R-DRE-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Danio rerio)
REACT:R-BTA-8938829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Bos taurus)
RHEA:63024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenamide + H2O = (13Z)-docosenoate + NH4(+)
RHEA:70222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + H(+) + NADPH <=> 20beta-dihydrocorticosterone + NADP(+)
REACT:R-BTA-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Bos taurus)
REACT:R-CFA-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Canis familiaris)
REACT:R-PFA-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Plasmodium falciparum)
REACT:R-XTR-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Xenopus tropicalis)
RHEA:36154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamyl alcohol + acetyl-CoA <=> (E)-cinnamyl acetate + CoA
RHEA:61789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-tryptophan => AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]
RHEA:57176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + methylglyoxal = N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]
RHEA:38310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-HSA-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Homo sapiens)
RHEA:64267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrochrysone carboxylate + H(+) <=> atrochrysone + CO2
REACT:R-DRE-9693978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Small molecule inhibitor binds RIPK1, RIPK3 (Danio rerio)
RHEA:54211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O
REACT:R-DRE-202731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM3 dimerises (Danio rerio)
REACT:R-XTR-9020264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Xenopus tropicalis)
REACT:R-DME-156661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Exon Junction Complex (Drosophila melanogaster)
RHEA:11560	skos:altLabel	"DHB dehydrogenase"
RHEA:11560	skos:altLabel	"cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase"
RHEA:11560	skos:altLabel	"cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase"
RHEA:11560	skos:altLabel	"DHBDH"
RHEA:11560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) = catechol + CO2 + NADH
RHEA:11560	skos:prefLabel	"1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase"
RHEA:11560	skos:altLabel	"3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase"
RHEA:11560	skos:altLabel	"2-hydro-1,2-dihydroxybenzoate dehydrogenase"
RHEA:11560	skos:altLabel	"dihydrodihydroxybenzoate dehydrogenase"
RHEA:11560	skos:altLabel	"3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase"
RHEA:11560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase"
GO:0034796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adipate-CoA ligase activity
RHEA:11159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-valine + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)
REACT:R-SSC-9612501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates CREB1 (Sus scrofa)
REACT:R-CFA-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Canis familiaris)
RHEA:48522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O
RHEA:19150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + NAD(+) => H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
RHEA:52862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty acyl-CoA + AMP + diphosphate => a short-chain fatty acid + ATP + CoA
RHEA:29599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monacolin L hydroxylase"
RHEA:29599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]
RHEA:29599	skos:prefLabel	"monacolin L hydroxylase"
REACT:R-GGA-169905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS is phosphorylated by active TrkA receptor (Gallus gallus)
REACT:R-DRE-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Danio rerio)
REACT:R-HSA-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Homo sapiens)
RHEA:30729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dADP + H(+) + phosphoenolpyruvate => dATP + pyruvate
REACT:R-BTA-391940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 and EP4 receptors can bind PGE2 (Bos taurus)
GO:0034944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity
RHEA:48330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E)) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose
REACT:R-XTR-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)
REACT:R-BTA-377641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
RHEA:35964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A => fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-2730858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of BTK/ITK (Gallus gallus)
RHEA:28419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + gamma-butyrobetainyl-CoA => (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate
REACT:R-BTA-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Bos taurus)
RHEA:23598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 2 NADH + UDP-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-alpha-D-glucose
REACT:R-BTA-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Bos taurus)
REACT:R-HSA-1247939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysGly translocates from extracellular region to cytosol (Homo sapiens)
RHEA:42953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(49) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphoserine aminotransferase activity
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phosphoserine aminotransferase activity
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxypyruvic phosphate--glutamic transaminase activity
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PdxC
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphohydroxypyruvate transaminase activity
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PSAT activity
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SerC
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphoserine aminotransferase activity
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphoserine transaminase activity
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-phospho-L-serine:2-oxoglutarate aminotransferase activity
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3PHP transaminase activity
GO:0004648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphohydroxypyruvic--glutamic transaminase activity
REACT:R-HSA-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Homo sapiens)
REACT:R-GGA-912757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S585-IL3RB binds 14-3-3 proteins (Gallus gallus)
RHEA:64462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate => acetyl phosphate + L-lysyl-[protein]
REACT:R-HSA-5683384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UIMC1 and FAM175A bind DNA DSBs (Homo sapiens)
RHEA:57672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] = 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)
REACT:R-HSA-444654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled bile acid receptor binds lithocholic acid (Homo sapiens)
REACT:R-CEL-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Caenorhabditis elegans)
RHEA:22213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate => (2R,3S)-tartrate
REACT:R-HSA-382061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular processing of novel PDGFs (Homo sapiens)
REACT:R-GGA-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Gallus gallus)
RHEA:61606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-disulfide + [DsbB protein]-dithiol => [DsbA protein]-dithiol + [DsbB protein]-disulfide
REACT:R-BTA-201425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Bos taurus)
REACT:R-CEL-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Caenorhabditis elegans)
REACT:R-SSC-5691411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Sus scrofa)
REACT:R-DRE-420739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPRC6A can bind L-alpha amino acids and calcium (Danio rerio)
REACT:R-MMU-5333678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPNEs bind PL (Mus musculus)
REACT:R-MMU-5218854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y420-FYN is phosphorylated on S21 (Mus musculus)
RHEA:29077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2(out) + H(+)(out) + ubiquinol-8 => formate(out) + 2 H(+)(in) + ubiquinone-8
RHEA:72123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-butanoyl-(R)-carnitine(out) = Na(+)(in) + O-butanoyl-(R)-carnitine(in)
RHEA:55479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine
RHEA:37526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:55820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine
REACT:R-HSA-199576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR3DL2 interacting with HLA-A3 (Homo sapiens)
RHEA:39794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-3301943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTK1 dimer transfers GS from GSH to CDNB (Mus musculus)
RHEA:37481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:61405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(D-ribulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine
REACT:R-GGA-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Gallus gallus)
REACT:R-GGA-69562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Gallus gallus)
REACT:R-BTA-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Bos taurus)
REACT:R-DME-9663492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL dissociates from GSTA1, FABP1 (Drosophila melanogaster)
REACT:R-MMU-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Mus musculus)
RHEA:41315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
RHEA:54353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:20072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenylacetaldehyde oxime <=> H2O + phenylacetonitrile
REACT:R-HSA-429698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKD1,2,3 phosphorylates CERT1-2 (Homo sapiens)
REACT:R-RNO-5685341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex stabilizes RAD51 filament (Rattus norvegicus)
REACT:R-BTA-5357831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD is phosphorylated by IKK (Bos taurus)
REACT:R-HSA-9661723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)
REACT:R-CFA-420591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-2:Nectin 3 trans heterodimer interaction (Canis familiaris)
REACT:R-HSA-163670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear transport of pChREBP (Thr 666) protein (Homo sapiens)
RHEA:57564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9679421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCD1 binds PDCD1 inhibitors (Mus musculus)
REACT:R-DDI-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)
REACT:R-CFA-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)
GO:0047173	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lecithin--retinol acyltransferase activity
GO:0047173	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity
GO:0047173	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity
GO:0047173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine-retinol O-acyltransferase activity
RHEA:44033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxy-(12Z)-octadecenoate + H2O => 9,10-dihydroxy-(12Z)-octadecenoate
REACT:R-HSA-2161791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Homo sapiens)
REACT:R-DRE-5578783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Danio rerio)
REACT:R-HSA-351604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline translocates to the cytosol (Homo sapiens)
REACT:R-GGA-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Gallus gallus)
REACT:R-PFA-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Plasmodium falciparum)
REACT:R-SCE-68954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm2-7 is phosphorylated by DDK (Saccharomyces cerevisiae)
RHEA:33815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate = 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)
RHEA:33815	skos:altLabel	"Tag primase"
RHEA:33815	skos:prefLabel	"teichoic acid glycerol-phosphate primase"
RHEA:33815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"teichoic acid glycerol-phosphate primase"
REACT:R-HSA-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Homo sapiens)
RHEA:22614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + pyruvate => (3S)-citramalyl-CoA
REACT:R-HSA-9717374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)
RHEA:64196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-lysine + H2O = a fatty acid + L-lysine
RHEA:65273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin C + H(+) + NADPH + O2 => chrodrimanin H + H2O + NADP(+)
RHEA:40945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
RHEA:14548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nicotinamide <=> NH4(+) + nicotinate
RHEA:36339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine
GO:0043325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,4-bisphosphate binding
RHEA:27399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + dichloroarcyriaflavin A => 4'-demethylrebeccamycin + H2O
GO:0018071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)-cysteine ADP-ribosyltransferase activity
REACT:R-BTA-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Bos taurus)
REACT:R-BTA-3322422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits SMARCA4 (Bos taurus)
REACT:R-SSC-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Sus scrofa)
REACT:R-HSA-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Homo sapiens)
REACT:R-XTR-3965447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein subunits dissociate from WNT:FZD complex (Xenopus tropicalis)
REACT:R-XTR-5229010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-27 of histone H3 (H3R26) (Xenopus tropicalis)
REACT:R-GGA-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Gallus gallus)
GO:0080103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylthiopropyl glucosinolate S-oxygenase activity
REACT:R-HSA-976810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to extracellular Factor H:C3b (Homo sapiens)
REACT:R-SSC-9750942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP14 deubiquitinates NLRC5 (Sus scrofa)
RHEA:56961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + pyruvate => a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate
RHEA:69660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kaempferol 3-O-beta-D-glucoside => beta-D-glucose + kaempferol
RHEA:54176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + holo-[ACP] + NADP(+) = a long-chain fatty acyl-[ACP] + H(+) + NADPH
RHEA:38891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4-enine
RHEA:38225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-decyl-(9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + decan-1-ol
REACT:R-BTA-177275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates DARPP-32 on Thr34 (Bos taurus)
RHEA:10239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2-coumarate + UDP-alpha-D-glucose <=> H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP
REACT:R-DDI-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Dictyostelium discoideum)
RHEA:16730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH
RHEA:39133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA
RHEA:22236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-deoxyglucose-6-phosphatase"
RHEA:22236	skos:altLabel	"2-deoxyglucose-6-phosphate phosphatase"
RHEA:22236	skos:prefLabel	"2-deoxyglucose-6-phosphatase"
RHEA:22236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate
REACT:R-SSC-375302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules (Sus scrofa)
REACT:R-SSC-5693602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM recognizes H2AFX-Nucleosomes (Sus scrofa)
GO:0050123	skos:prefLabel	"N-acylmannosamine 1-dehydrogenase"
GO:0050123	skos:altLabel	"N-acyl-D-mannosamine dehydrogenase"
GO:0050123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-mannosamine dehydrogenase activity
GO:0050123	skos:altLabel	"N-acylmannosamine dehydrogenase"
GO:0050123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-D-mannosamine dehydrogenase activity
GO:0050123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity
GO:0050123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine + NAD(+) = an N-acyl-D-mannosaminolactone + H(+) + NADH
GO:0050123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylmannosamine 1-dehydrogenase activity
GO:0050123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acylmannosamine 1-dehydrogenase"
GO:0050123	skos:altLabel	"N-acetyl-D-mannosamine dehydrogenase"
GO:0050123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acylmannosamine dehydrogenase activity
RHEA:29759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanoate(in) = octanoate(out)
RHEA:42027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) <=> 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH
RHEA:15954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + ATP => ADP + 2 H(+) + N(4)-phosphoagmatine
RHEA:61834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + sitosteryl 3-beta-D-glucoside + UDP => sitosterol + UDP-alpha-D-glucose
REACT:R-BTA-6785732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases bind monoubiquitinated ID2 complex (Bos taurus)
REACT:R-SPO-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Schizosaccharomyces pombe)
REACT:R-MMU-112436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin complex (Mus musculus)
REACT:R-HSA-373729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin binds Ankyrin-G (Homo sapiens)
RHEA:56957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITP + pyruvate => H(+) + IDP + phosphoenolpyruvate
RHEA:26459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylnitronate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + nitrite
EC:3.1.1.86	skos:altLabel	"RGAE"
EC:3.1.1.86	skos:prefLabel	"rhamnogalacturonan acetylesterase"
EC:3.1.1.86	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnogalacturonan acetylesterase"
GO:0016746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring acyl groups
GO:0016746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRASLS transfer acyl group from PC to PE to form NAPE (Homo sapiens)
GO:0016746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyltransferase activity
REACT:R-MMU-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Mus musculus)
REACT:R-RNO-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Rattus norvegicus)
REACT:R-HSA-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Homo sapiens)
RHEA:41071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:49855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-octenoyl-CoA <=> (2E)-octenoyl-CoA
REACT:R-HSA-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Homo sapiens)
REACT:R-CFA-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Canis familiaris)
RHEA:72504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + prostaglandin F2alpha(out) => glutarate(out) + prostaglandin F2alpha(in)
REACT:R-MMU-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Mus musculus)
REACT:R-DME-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Drosophila melanogaster)
REACT:R-XTR-1433456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs (Xenopus tropicalis)
RHEA:55155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] <=> (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]
GO:0051008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hsp27 protein binding
REACT:R-RNO-936963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)
REACT:R-BTA-182988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty lures CBL away from EGFR (Bos taurus)
REACT:R-DDI-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Dictyostelium discoideum)
REACT:R-HSA-8983335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)
REACT:R-GGA-202478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction and oligomerization of MALT1 to Bcl10 (Gallus gallus)
REACT:R-MMU-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Mus musculus)
RHEA:48743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine <=> [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate
REACT:R-XTR-193068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)
REACT:R-CFA-2028629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Canis familiaris)
GO:0004673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-histidine kinase activity
GO:0004673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine protein kinase activity
GO:0004673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine kinase activity
GO:0004673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein-L-histidine N-phosphotransferase activity
GO:0004673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein kinase (histidine)
GO:0004673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein histidine kinase activity
REACT:R-SCE-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Saccharomyces cerevisiae)
REACT:R-RNO-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Rattus norvegicus)
RHEA:31532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginine + O2 => CO2 + N(omega)-hydroxy-L-arginine + succinate
RHEA:40956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-phosphomevalonate + ATP => ADP + CO2 + isopentenyl phosphate + phosphate
REACT:R-HSA-1614654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Homo sapiens)
RHEA:21530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n-1) + H(+) + phosphate => [phosphate](n) + H2O
RHEA:29059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + H2 + ubiquinone-8 = 2 H(+)(out) + ubiquinol-8
REACT:R-BTA-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Bos taurus)
REACT:R-MMU-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Mus musculus)
REACT:R-GGA-5687465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds RBBP8 (Gallus gallus)
RHEA:10228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate = cis-aconitate + H2O
REACT:R-SPO-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Schizosaccharomyces pombe)
REACT:R-SSC-2022381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)
REACT:R-HSA-9657619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)
RHEA:22923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + scyllo-inosose <=> 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate
REACT:R-RNO-9700121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN,MDK):PTPRZ oligomerizes (Rattus norvegicus)
REACT:R-SPO-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Schizosaccharomyces pombe)
REACT:R-BTA-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Bos taurus)
REACT:R-BTA-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Bos taurus)
REACT:R-DRE-5684081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds CDK2 and RBBP8 (Danio rerio)
RHEA:36610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginine + O2 <=> (2S,3S)-hydroxyarginine + CO2 + succinate
REACT:R-SSC-201515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK recruits PI3K (Sus scrofa)
RHEA:25095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dCMP => ADP + dCDP
GO:0050340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTMPase activity
GO:0050340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidylate 5'-phosphatase activity
GO:0050340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidylate nucleotidase activity
GO:0050340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidylate 5'-nucleotidase activity
GO:0050340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidylate 5' phosphatase activity
GO:0050340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxythymidylic 5'-nucleotidase activity
GO:0050340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxythymidylate 5'-nucleotidase activity
GO:0050340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxythymidylate phosphohydrolase activity
GO:0050340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidylate 5'-phosphohydrolase activity
REACT:R-BTA-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
REACT:R-BTA-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Bos taurus)
REACT:R-BTA-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Bos taurus)
RHEA:11405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate => UDP-alpha-D-galacturonate
RHEA:11766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylamine + urea => H2O + methylguanidine
RHEA:10445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + S-adenosyl-L-methionine => (S)-laudanine + H(+) + S-adenosyl-L-homocysteine
RHEA:17669	skos:prefLabel	"melilotate 3-monooxygenase"
RHEA:17669	skos:altLabel	"melilotic hydroxylase"
RHEA:17669	skos:altLabel	"melilotate hydroxylase"
RHEA:17669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"melilotate 3-monooxygenase"
RHEA:17669	skos:altLabel	"2-hydroxyphenylpropionate hydroxylase"
RHEA:17669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)
GO:0070448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonoid 3',5'-O-dimethyltransferase activity
GO:0070448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CrCOMT2
GO:0070448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:myricetin O-methyltransferase activity
GO:0070448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laricitrin 5'-O-methyltransferase activity
RHEA:36570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-colitose + NAD(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH
RHEA:51921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + AH2 => A + a quinol
REACT:R-BTA-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
REACT:R-SSC-2454118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cRAL binds to opsin to form 11c-retinyl:RHO (Sus scrofa)
RHEA:16568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidine <=> 3-(imidazol-5-yl)pyruvate + L-glutamate
RHEA:34173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => L-aspartate 4-semialdehyde + pyruvate
REACT:R-RNO-1067659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of hexameric IL-6 receptor (Rattus norvegicus)
REACT:R-CEL-209924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is decarboxylated to dopamine (Caenorhabditis elegans)
REACT:R-CFA-5654587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS phosphorylates PPTN11 (Canis familiaris)
RHEA:64738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H(+) + NADPH => 4-hydroxynonanal + NADP(+)
REACT:R-HSA-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Homo sapiens)
REACT:R-BTA-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Bos taurus)
REACT:R-GGA-189384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLVRA:Zn2+, BLVRB reduce BV to BIL (Gallus gallus)
RHEA:50559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D2 <=> H2O + prostaglandin J2
REACT:R-DDI-198609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)
REACT:R-GGA-432129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds and phosphorylates LRP8 (Gallus gallus)
REACT:R-DME-110518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated DTOR also phosphorylates D4EBP (Drosophila melanogaster)
RHEA:10111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-salutaridinol + NADP(+) <=> H(+) + NADPH + salutaridine
REACT:R-DRE-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Danio rerio)
REACT:R-BTA-2161961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EET(1) is hydrolysed to DHET(1) by EPHX2 (Bos taurus)
REACT:R-RNO-202726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F11R dimerises (Rattus norvegicus)
REACT:R-DDI-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Dictyostelium discoideum)
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	assimilatory NADH: nitrate reductase activity
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH:nitrate reductase activity
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate reductase (NADH) activity
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	assimilatory nitrate reductase activity
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate reductase (NADH2)
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	assimilatory NADH:nitrate reductase activity
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dependent nitrate reductase activity
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-nitrate reductase activity
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite:NAD+ oxidoreductase activity
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate reductase (NADH(2)) activity
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + nitrite = H(+) + NADH + nitrate
GO:0009703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:nitrate oxidoreductase activity
RHEA:13339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + H(+) => D-glucurono-6,2-lactone + H2O
GO:0050259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 1-dehydrogenase (NADP+) activity
GO:0050259	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribose:NADP+ 1-oxidoreductase activity
GO:0050259	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribose dehydrogenase (NADP+)
GO:0050259	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-pentose-dehydrogenase activity
REACT:R-RNO-9677929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB inhibitors bind MAOB:FAD (Rattus norvegicus)
REACT:R-HSA-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Homo sapiens)
REACT:R-DME-6799197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Drosophila melanogaster)
GO:0102172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity
REACT:R-RNO-416358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) inhibits PI3K alpha (Rattus norvegicus)
RHEA:60677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(-)-citronellol + NAD(+) => (S)-(-)-citronellal + H(+) + NADH
REACT:R-CFA-1236967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alkalization of the phagosomal lumen by NOX2 (Canis familiaris)
RHEA:16803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein] => 3'-phosphoadenylyl sulfate + L-tyrosyl-[protein]
RHEA:35413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+) => (E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside
REACT:R-HSA-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Homo sapiens)
REACT:R-DDI-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)
REACT:R-CFA-2130349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Generation of CLIP from lip10 (Canis familiaris)
REACT:R-GGA-114354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP:Caspase-7 (Gallus gallus)
REACT:R-DRE-5578965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A binds AGO2:miRNA (Danio rerio)
RHEA:56860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase"
RHEA:56860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate = a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]
RHEA:56860	skos:prefLabel	"2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase"
REACT:R-HSA-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Homo sapiens)
RHEA:21422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-dehydro-prostaglandin I2 + H(+) + NADPH => NADP(+) + prostaglandin I2
GO:0046316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gluconokinase (phosphorylating)
GO:0046316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gluconokinase activity
GO:0046316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gluconate kinase activity
GO:0046316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-gluconate 6-phosphotransferase activity
REACT:R-XTR-5654169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 (Xenopus tropicalis)
RHEA:47028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfo-L-cysteine/L-cysteine = [DsrC protein]-disulfide + H(+) + sulfite
RHEA:34170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypseudooxynicotine + H2O <=> 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)
RHEA:50732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-374692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neogenin binds repulsive guidance molecules (RGDs) (Homo sapiens)
GO:0045504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynein heavy chain binding
REACT:R-BTA-5686440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81:EME1,EME2 cleaves D-loop (Bos taurus)
RHEA:13601	skos:prefLabel	"4-oxoproline reductase"
RHEA:13601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-oxoproline reductase"
RHEA:13601	skos:altLabel	"cis-hydroxy-L-proline oxidase"
RHEA:13601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + H(+) + NADH
REACT:R-CEL-110141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Caenorhabditis elegans)
REACT:R-BTA-5687088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates MAPKAPK5 (Bos taurus)
RHEA:32910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine
RHEA:56179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O <=> 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)
RHEA:25044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + 2 phosphate
REACT:R-MMU-879942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor is activated (Mus musculus)
RHEA:60234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2
RHEA:62758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-SSC-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Sus scrofa)
REACT:R-CFA-9620515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2B,EP300 acetylate FOXO3 under oxidative stress (Canis familiaris)
REACT:R-MMU-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)
RHEA:58501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + H(+) + NADH + O2 => glyoxylate + H2O + NAD(+) + trimethylamine
REACT:R-XTR-5654673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Xenopus tropicalis)
REACT:R-PFA-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Plasmodium falciparum)
RHEA:49298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + L-sorbose 1-phosphate(in) => keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein]
RHEA:69874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-9620515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2B,EP300 acetylate FOXO3 under oxidative stress (Danio rerio)
RHEA:24570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + D-galactose 6-phosphate => a 6-phospho-beta-D-galactoside + H2O
RHEA:13292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP
RHEA:71420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) => 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)
RHEA:49537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O
RHEA:40480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:49553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => H(+) + L-lysyl-[protein] + lactate
EC:7.6.2.1	skos:prefLabel	"P-type phospholipid transporter"
EC:7.6.2.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type phospholipid transporter"
EC:7.6.2.1	skos:altLabel	"phospholipid-transporting ATPase"
EC:7.6.2.1	skos:altLabel	"flippase"
RHEA:56539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA
REACT:R-CFA-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)
GO:0004836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyramine-beta hydroxylase activity
REACT:R-XTR-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Xenopus tropicalis)
REACT:R-DRE-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Danio rerio)
REACT:R-SSC-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Sus scrofa)
RHEA:72792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin-glucuronoside(out) => bilirubin-glucuronoside(in)
RHEA:59163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]
REACT:R-CFA-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Canis familiaris)
REACT:R-CFA-444661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR2 binds HCAR2 ligands (Canis familiaris)
RHEA:39010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cholesterol ester(in) <=> a cholesterol ester(out)
REACT:R-DME-8878054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 (Drosophila melanogaster)
REACT:R-HSA-163096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)
REACT:R-RNO-203130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OLR1 binds to oxidized LDL (Rattus norvegicus)
REACT:R-HSA-198621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates caspase-9 (Homo sapiens)
RHEA:12112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine
RHEA:12112	skos:altLabel	"indolepyruvate methyltransferase"
RHEA:12112	skos:prefLabel	"indolepyruvate C-methyltransferase"
RHEA:12112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indolepyruvate C-methyltransferase"
RHEA:12112	skos:altLabel	"indolepyruvate 3-methyltransferase"
RHEA:12112	skos:altLabel	"indolepyruvic acid methyltransferase"
REACT:R-XTR-3262512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Xenopus tropicalis)
RHEA:71955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + 3 Na(+)(out) = glutarate(in) + 3 Na(+)(in)
REACT:R-MMU-2990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO1 to UBA2:SAE1 (Mus musculus)
REACT:R-MMU-159425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
RHEA:49468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose = a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP
REACT:R-DRE-5676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD74 binds MIF (Danio rerio)
RHEA:17806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-adenosyl-L-homocysteine => adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine
REACT:R-RNO-9645414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Rattus norvegicus)
REACT:R-DME-9029150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Drosophila melanogaster)
RHEA:25110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + pyridoxine 5'-phosphate => ATP + pyridoxine
REACT:R-HSA-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Homo sapiens)
REACT:R-SSC-9688456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds FLOT1, FLOT2 (Sus scrofa)
REACT:R-CFA-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Canis familiaris)
REACT:R-CEL-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Caenorhabditis elegans)
RHEA:69659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kaempferol 3-O-beta-D-glucoside = beta-D-glucose + kaempferol
REACT:R-SSC-1676020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Sus scrofa)
REACT:R-SSC-8852019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET bound PI3K generates PIP3 (Sus scrofa)
RHEA:11132	skos:altLabel	"NADPH-protochlorophyllide oxidoreductase"
RHEA:11132	skos:altLabel	"protochlorophyllide oxidoreductase"
RHEA:11132	skos:prefLabel	"protochlorophyllide reductase"
RHEA:11132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protochlorophyllide reductase"
RHEA:11132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + NADP(+) = H(+) + NADPH + protochlorophyllide a
RHEA:11132	skos:altLabel	"light-dependent protochlorophyllide reductase"
REACT:R-MMU-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Mus musculus)
RHEA:29821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-isoleucine(in) + phosphate => ATP + H2O + L-isoleucine(out)
RHEA:30881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + propynoate => H2O + NAD(+) + prop-2-ynal
REACT:R-DME-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Drosophila melanogaster)
REACT:R-RNO-201640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Rattus norvegicus)
REACT:R-CFA-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Canis familiaris)
REACT:R-RNO-110351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of SMUG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
RHEA:29367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H2O = cytidine + phosphate
REACT:R-DRE-8950448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Danio rerio)
REACT:R-BTA-2299620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen XI cross-links with collagen II (Bos taurus)
REACT:R-SPO-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Schizosaccharomyces pombe)
RHEA:42331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-SPO-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Schizosaccharomyces pombe)
REACT:R-SSC-3215385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Sus scrofa)
REACT:R-BTA-70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Bos taurus)
RHEA:70929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate(out) + H(+)(out) => (R)-glycerate(in) + H(+)(in)
RHEA:46909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol
RHEA:30236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + L-glutamate + NADH
RHEA:12648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:61535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-2426471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Bos taurus)
REACT:R-HSA-8848110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds activated PTK6 (Homo sapiens)
RHEA:34461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sclareol => 8-hydroxycopalyl diphosphate + H2O
REACT:R-CFA-8874201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L3 (Canis familiaris)
REACT:R-SCE-2990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO1 to UBA2:SAE1 (Saccharomyces cerevisiae)
RHEA:72896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine => 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine
REACT:R-CFA-2203480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC11 binds ligands (Canis familiaris)
GO:0042767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysteroid 22-hydroxylase activity
REACT:R-BTA-74740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SHC1 to insulin receptor (Bos taurus)
RHEA:52282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate
GO:0008011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of pupal chitin-based cuticle
GO:0008011	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	structural constituent of pupal cuticle
RHEA:27794	skos:altLabel	"trans-hexaprenyltranstransferase"
RHEA:27794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heptaprenyl diphosphate synthase"
RHEA:27794	skos:altLabel	"HepPP synthase"
RHEA:27794	skos:altLabel	"heptaprenyl pyrophosphate synthetase"
RHEA:27794	skos:altLabel	"all-trans-heptaprenyl-diphosphate synthase"
RHEA:27794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 4 diphosphate
RHEA:27794	skos:prefLabel	"heptaprenyl diphosphate synthase"
REACT:R-MMU-8848713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds BCAR1 (Mus musculus)
GO:0008456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity
GO:0008456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-acetylgalactosaminidase activity
GO:0008456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-acetylgalactosaminidase activity
GO:0008456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-galactosidase B activity
GO:0008456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-NAGA activity
GO:0008456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-alpha-galactosaminidase activity
GO:0008456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-alpha-D-galactosaminidase activity
RHEA:28008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O2 + L-tryptophan => H2O + N(alpha)-methyl-L-tryptophan + O2
REACT:R-CEL-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-DDI-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
RHEA:14867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-methyltyramine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tyramine
REACT:R-DRE-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Danio rerio)
REACT:R-SCE-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Saccharomyces cerevisiae)
RHEA:32041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate
GO:0033899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease (purine) activity
GO:0033899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine-specific ribonuclease activity
GO:0033899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine specific endoribonuclease activity
GO:0033899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase U2 activity
GO:0033899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pleospora RNase activity
GO:0033899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease U2 activity
GO:0033899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine-specific RNase activity
GO:0033899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trichoderma koningi RNase III activity
REACT:R-DME-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Drosophila melanogaster)
EC:2.3.1.136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polysialic-acid O-acetyltransferase"
EC:2.3.1.136	skos:prefLabel	"polysialic-acid O-acetyltransferase"
GO:0047534	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetohydroxy acid isomerase activity
GO:0047534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetolactate mutase activity
GO:0047534	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-acetolactate methylmutase activity
GO:0047534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetolactate mutase activity
GO:0102971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphinothricin N-acetyltransferase activity
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	firefly luciferase activity
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Photinus pyralis luciferase activity
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	firefly luciferin luciferase activity
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	luciferase activity
GO:0047077	skos:prefLabel	"firefly luciferase"
GO:0047077	skos:altLabel	"Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing)"
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + firefly D-luciferin + O2 = AMP + CO2 + diphosphate + firefly oxyluciferin + hnu
GO:0047077	skos:altLabel	"Photinus pyralis luciferase"
GO:0047077	skos:altLabel	"luciferase"
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"firefly luciferase"
GO:0047077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	luciferase (firefly luciferin)
REACT:R-SCE-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Saccharomyces cerevisiae)
REACT:R-SPO-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Schizosaccharomyces pombe)
REACT:R-GGA-2132088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vitronectin prevents C9 polymerization (Gallus gallus)
REACT:R-HSA-189456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial dALA translocates to cytosol (Homo sapiens)
RHEA:57834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate + 2 H(+) + NADPH => 5-oxopentanoate + H2O + NADP(+)
REACT:R-BTA-421426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ProGIP translocates from the ER Lumen to secretory granules (Bos taurus)
REACT:R-SSC-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)
REACT:R-BTA-201443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II receptor phosphorylates type I receptor (Bos taurus)
RHEA:45537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine
RHEA:62638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O => (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide
RHEA:58893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 => adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9
RHEA:54377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O => diphosphate + nezukol
REACT:R-CEL-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Caenorhabditis elegans)
RHEA:21142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + IMP => ATP + inosine
REACT:R-SSC-8863973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of ERC and phagosome (Sus scrofa)
REACT:R-CFA-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Canis familiaris)
REACT:R-SSC-266310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:spherical HDL complex <=> LCAT + spherical HDL (Sus scrofa)
RHEA:31463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crocetin + UDP-alpha-D-glucose = beta-D-glucosyl crocetin + UDP
REACT:R-MMU-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Mus musculus)
RHEA:38994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)
REACT:R-XTR-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-DRE-4551451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Danio rerio)
RHEA:32698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (-)-car-3-ene + diphosphate
REACT:R-HSA-3814838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GYG1 is not autoglucosyolated (Homo sapiens)
REACT:R-MMU-443986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor ACKR2 binds most inflammatory CC chemokines (Mus musculus)
REACT:R-CFA-9750946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
RHEA:71811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)
REACT:R-CEL-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Caenorhabditis elegans)
REACT:R-HSA-8878212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAG1 gene expression is inhibited by RUNX3 (Homo sapiens)
RHEA:28845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline(out) + H(+)(out) => choline(in) + H(+)(in)
RHEA:31219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxykynurenamine + CO2 = 5-hydroxy-L-kynurenine + H(+)
REACT:R-MMU-205117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR:NADE promotes caspase2/3 activation (Mus musculus)
RHEA:46009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + pentanal => H(+) + NADH + pentanoyl-CoA
RHEA:39576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)
REACT:R-HSA-9758501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of MIXL1 in the primitive streak (Homo sapiens)
GO:0120283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein serine/threonine kinase binding
RHEA:58171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-5-epi-eremophilene + diphosphate
RHEA:56364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-dihydrocarminomycin + H(+) + NADPH + O2 = carminomycin + 2 H2O + NADP(+)
REACT:R-DRE-159729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)
REACT:R-HSA-9611751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1,2-agonists bind ADRB1,2 (Homo sapiens)
REACT:R-SSC-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Sus scrofa)
REACT:R-SSC-5340124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSN polymer binds CaPO4 (Sus scrofa)
RHEA:39193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + NADP(+) => (2E)-docosenoyl-CoA + H(+) + NADPH
RHEA:39000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine
REACT:R-RNO-77591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Rattus norvegicus)
REACT:R-HSA-1791122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PDIA5 (Homo sapiens)
RHEA:16018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ornithine => 5-amino-2-oxopentanoate + L-glutamate
REACT:R-RNO-72185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA polyadenylation (Rattus norvegicus)
REACT:R-XTR-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-BTA-9661419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds extracellular heme (Bos taurus)
REACT:R-RNO-265424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Rattus norvegicus)
REACT:R-HSA-5654623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS3 (Homo sapiens)
REACT:R-HSA-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Homo sapiens)
REACT:R-HSA-9708558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Homo sapiens)
REACT:R-DDI-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Dictyostelium discoideum)
RHEA:59958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nitrile + sulfate + sulfur => a (Z)-N-(sulfonatooxy)alkanimidothioate
GO:0047961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine N-acyltransferase activity
GO:0047961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine-N-acylase activity
GO:0047961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine acyltransferase activity
GO:0047961	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:glycine N-acyltransferase activity
REACT:R-XTR-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Xenopus tropicalis)
GO:0050248	skos:altLabel	"Renilla-luciferin 2-monooxygenase"
GO:0050248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Renilla-type luciferase"
GO:0050248	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aequorin activity
GO:0050248	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	luciferase activity
GO:0050248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine h + O2 = CO2 + excited coelenteramide h monoanion + H(+) + hnu
GO:0050248	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	luciferase (Renilla luciferin)
GO:0050248	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)
GO:0050248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renilla-luciferin 2-monooxygenase activity
GO:0050248	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Renilla-type luciferase activity
GO:0050248	skos:prefLabel	"Renilla-type luciferase"
GO:0050248	skos:altLabel	"luciferase"
REACT:R-BTA-977363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3bBb (Bos taurus)
RHEA:38545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein] => H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]
RHEA:13056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + pyruvate <=> 3-phenylpyruvate + L-alanine
RHEA:68778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + germacrene A => (2Z,6Z)-farnesyl diphosphate
GO:0030943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrion targeting sequence binding
GO:0030943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial targeting sequence binding
RHEA:72880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-(2-amino-1-hydroxyethyl)phosphonate => NH4(+) + phosphonoacetaldehyde
REACT:R-DME-9630923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
RHEA:59550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone => N,N',N''-triacetylchitotriose + O2
REACT:R-XTR-5579018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1(868-1441) binds PAX3(1-319) (Xenopus tropicalis)
REACT:R-CFA-1855159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Canis familiaris)
REACT:R-HSA-8874685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds MET (Homo sapiens)
REACT:R-SSC-166542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-NGF dimer binds to TrkA receptor (Sus scrofa)
RHEA:48967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 <=> [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O
RHEA:70856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + L-serine(in) + Na(+)(out) => L-glutamine(in) + L-serine(out) + Na(+)(in)
RHEA:42089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity
REACT:R-RNO-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Rattus norvegicus)
RHEA:46655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone + H(+) + NADPH <=> 5beta-dihydroepitestosterone + NADP(+)
REACT:R-MMU-8853792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET tyrosine phosphorylation (Mus musculus)
REACT:R-MMU-1855208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Mus musculus)
RHEA:29989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(out) + H(+)(out) => adenosine(in) + H(+)(in)
RHEA:21598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomalonate semialdehyde + H(+) + NADPH => L-serine + NADP(+)
REACT:R-HSA-193753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)
RHEA:47382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-SSC-430073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Sus scrofa)
REACT:R-CFA-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Canis familiaris)
REACT:R-HSA-2012073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3c P250R mutant (Homo sapiens)
RHEA:40199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:48447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol
RHEA:30843	skos:prefLabel	"N-formylmaleamate deformylase"
RHEA:30843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-formylmaleamate deformylase"
RHEA:30843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formylmaleamate = formate + H(+) + maleamate
REACT:R-GGA-139908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DLC2 by MAPK8 (Gallus gallus)
RHEA:62919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine <=> an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-BTA-1676005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Bos taurus)
GO:0102691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:benzyladenine 7-N-glucosyltransferase activity
RHEA:29838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactonate(in) + H(+)(in) <=> D-galactonate(out) + H(+)(out)
REACT:R-HSA-5649799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)
REACT:R-HSA-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Homo sapiens)
RHEA:16950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + NAD(+) => H(+) + NADH + scyllo-inosose
REACT:R-GGA-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Gallus gallus)
RHEA:23963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O2 + hexadecanoate <=> CO2 + 3 H2O + pentadecanal
RHEA:55026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-CEL-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
RHEA:42794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl hexadecanoate + CoA => cholesterol + hexadecanoyl-CoA
RHEA:33167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol
RHEA:66563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline + L-glutaminyl-[protein] <=> 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)
RHEA:53737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-halobenzoate + H(+) + NADH + O2 => a halide anion + catechol + CO2 + NAD(+)
RHEA:38368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA => 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA
REACT:R-HSA-9018334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive CXXC5 gene expresion (Homo sapiens)
REACT:R-GGA-5691439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRISC complex deubiquitinates NLRP3 (Gallus gallus)
GO:0008836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diaminopimelate decarboxylase activity
GO:0008836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAP decarboxylase activity
GO:0008836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)
GO:0008836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAP-decarboxylase activity
GO:0008836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-2,6-diaminoheptanedioate carboxy-lyase activity
GO:0008836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meso-diaminopimelate decarboxylase activity
GO:0008836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diaminopimelic acid decarboxylase activity
RHEA:58495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Fe(III)-enterobactin(out) + H2O <=> ADP + Fe(III)-enterobactin(in) + H(+) + phosphate
RHEA:71514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phylloquinone(out) <=> phylloquinone(in)
REACT:R-DDI-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Dictyostelium discoideum)
RHEA:31910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-norcoclaurine + S-adenosyl-L-methionine <=> (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine
RHEA:46014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + oxaloacetate => (S)-malate + a quinone
REACT:R-HSA-9612277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPARC gene transcription is stimulated by ERBB4s80 (Homo sapiens)
REACT:R-DME-5689111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 autoubiquitinates (Drosophila melanogaster)
REACT:R-RNO-166038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-bound CD14 binds LPS (Rattus norvegicus)
REACT:R-RNO-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Rattus norvegicus)
RHEA:63712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Mus musculus)
REACT:R-BTA-388809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTLA-4 binds B7-1/B7-2 (Bos taurus)
REACT:R-XTR-380311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Plk1 to centrosomes (Xenopus tropicalis)
REACT:R-SPO-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Schizosaccharomyces pombe)
GO:0102330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-[acp] elongase/decarboxylase activity
REACT:R-SPO-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Schizosaccharomyces pombe)
RHEA:58978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H(+) + H2O2 => H2O + malonaldehyde + O2
RHEA:54540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]
REACT:R-SCE-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Saccharomyces cerevisiae)
REACT:R-DRE-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Danio rerio)
RHEA:70030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine
GO:0098505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-rich strand telomeric DNA binding
REACT:R-CFA-176702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Processive Complex and Completed Telomere End (Canis familiaris)
RHEA:70429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + CoA + H(+) => H2O + phenylacetyl-CoA
REACT:R-DME-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Drosophila melanogaster)
REACT:R-DDI-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Dictyostelium discoideum)
GO:0090542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELYC domain binding
RHEA:46502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + phosphate + succinate + uridine-5'-aldehyde => 2-oxoglutarate + O2 + UMP
RHEA:13224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + NAD(+) <=> H(+) + mevaldate + NADH
REACT:R-MMU-173723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C8 binds C5b:C6:C7 (Mus musculus)
RHEA:36083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycerol + H(+) + phosphocholine
GO:0022879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity
GO:0022879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose PTS transporter activity
REACT:R-HSA-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Homo sapiens)
REACT:R-HSA-6798353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression (Homo sapiens)
REACT:R-HSA-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Homo sapiens)
RHEA:57811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-3-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite
REACT:R-XTR-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Xenopus tropicalis)
REACT:R-SSC-9708859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Sus scrofa)
REACT:R-BTA-9615348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR2 (Bos taurus)
REACT:R-RNO-8848873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARAP1 (Rattus norvegicus)
RHEA:30960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9'-di-cis-zeta-carotene + a quinone => 7,9,9'-tri-cis-neurosporene + a quinol
RHEA:63145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)-ethanolamine => (15Z)-tetracosenoate + ethanolamine
RHEA:69845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in RNA + H(+) + NADH => a 5,6-dihydrouridine in RNA + NAD(+)
GO:0102598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity
GO:0102598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]
GO:0102598	skos:prefLabel	"oryzalexin D synthase"
GO:0102598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oryzalexin D synthase"
GO:0102598	skos:altLabel	"CYP76M8"
RHEA:28289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:71054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(out) + L-methionine(in) <=> L-leucine(in) + L-methionine(out)
REACT:R-CEL-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Caenorhabditis elegans)
REACT:R-DRE-8956684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH polyubiquitinates TP73 (Danio rerio)
REACT:R-RNO-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Rattus norvegicus)
REACT:R-DME-173597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)
REACT:R-CFA-165708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated 4EBP1 from eIF4E (Canis familiaris)
RHEA:16352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chlorate <=> A + chlorite + H2O
REACT:R-XTR-169905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS is phosphorylated by active TrkA receptor (Xenopus tropicalis)
EC:1.14.99.57	skos:prefLabel	"heme oxygenase (mycobilin-producing)"
EC:1.14.99.57	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heme oxygenase (mycobilin-producing)"
RHEA:18096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + NADP(+) <=> H(+) + NADPH + uracil
RHEA:50420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] = H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)
RHEA:71193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid(out) + L-kynurenine(in) => an L-alpha-amino acid(in) + L-kynurenine(out)
REACT:R-MMU-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Mus musculus)
REACT:R-CFA-5218811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO binds CRK (Canis familiaris)
RHEA:70860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(in) + L-glutamine(out) + Na(+)(out) => L-asparagine(out) + L-glutamine(in) + Na(+)(in)
REACT:R-SSC-173631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1s (Sus scrofa)
RHEA:21993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysyl-[histone] => CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]
RHEA:43240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate
REACT:R-HSA-72160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
REACT:R-XTR-5691154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HFE binds TFRC dimer (Xenopus tropicalis)
RHEA:45880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA
RHEA:25885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + N(2)-succinyl-L-ornithine => H(+) + N(2)-succinyl-L-citrulline + phosphate
GO:0034700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allulose 6-phosphate 3-epimerase activity
REACT:R-SCE-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)
REACT:R-XTR-6807826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDHAL6B reduces PYR to LACT (Xenopus tropicalis)
RHEA:17278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
REACT:R-RNO-193650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR binds to NADE (Rattus norvegicus)
REACT:R-GGA-5696358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREM,CD300 binds lipids (Gallus gallus)
RHEA:48127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 (d18:1(4E)) + H2O <=> ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate
GO:0047847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyuridine:phosphate deoxy-D-ribosyltransferase activity
GO:0047847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity
GO:0047847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyuridine phosphorylase activity
GO:0047847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity
REACT:R-CFA-2396399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillins bind BMPs (Canis familiaris)
REACT:R-GGA-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Gallus gallus)
REACT:R-XTR-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)
RHEA:49222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP
RHEA:19512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 2 H(+) + L-erythro-biopterin + 2 NADPH
RHEA:13430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) => 4-CDP-2-C-methyl-D-erythritol + diphosphate
RHEA:22106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-deamino-3''-oxonicotianamine + L-glutamate => 2-oxoglutarate + nicotianamine
REACT:R-HSA-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Homo sapiens)
REACT:R-BTA-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Bos taurus)
RHEA:17478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6B + 2 S-adenosyl-L-methionine => CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine
RHEA:32078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate
RHEA:32914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphocholine(out) <=> sn-glycerol 3-phosphocholine(in)
RHEA:33257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-7 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-7 + S-adenosyl-L-methionine
REACT:R-XTR-8856223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Xenopus tropicalis)
RHEA:70904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate => (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)
RHEA:60067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)
RHEA:42706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => hercynine + L-cysteine + O2
RHEA:23102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dADP => ATP + dAMP
REACT:R-CEL-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Caenorhabditis elegans)
REACT:R-CEL-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Caenorhabditis elegans)
REACT:R-GGA-353435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by Pol eta (Gallus gallus)
RHEA:44988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 2-methylpropanoyl-CoA = CoA + O-isobutanoyl-(R)-carnitine
RHEA:54639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-yl diphosphate <=> diphosphate + labda-7,13(16),14-triene
REACT:R-MMU-5684008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBN binds KPNA2 (Mus musculus)
GO:0120146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfated galactocerebroside binding
GO:0120146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfatide binding
GO:0120146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SM4 binding
GO:0120146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-sulfogalactosylceramide binding
REACT:R-HSA-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Homo sapiens)
RHEA:40483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)
RHEA:20737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + glycine => (2S)-2-amino-3-oxobutanoate + CoA
REACT:R-CFA-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Canis familiaris)
RHEA:61457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chlorotetracycline + H(+) + NADPH + O2 => (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)
REACT:R-SSC-8849353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Sus scrofa)
RHEA:15330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + NAD(+) => H(+) + N-carbamoyl-2-oxoglycine + NADH
REACT:R-DRE-381496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the IGF:IGFBP3:ALS complex (Danio rerio)
REACT:R-RNO-9020277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Rattus norvegicus)
RHEA:22810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxynicotinate + H2O2 => 6-hydroxynicotinate + H2O + O2
EC:2.3.-.-	skos:prefLabel	"Acyltransferases"
EC:2.3.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acyltransferases"
RHEA:58447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-GGA-5591040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves Factor Va intermediate form for Factor Va (Gallus gallus)
REACT:R-XTR-8851298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR143 binds L-Dopa (Xenopus tropicalis)
GO:0140901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:L-asparagine symporter activity
GO:0140901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:asparagine symporter activity
GO:0140901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine:sodium symporter activity
GO:0140901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagine:sodium symporter activity
RHEA:65920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + pyruvate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
RHEA:37791	skos:prefLabel	"aclacinomycin-A oxidase"
RHEA:37791	skos:altLabel	"AknOx"
RHEA:37791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aclacinomycin-A oxidase"
RHEA:37791	skos:altLabel	"aclacinomycin oxidoreductase"
RHEA:37791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin A + O2 = aclacinomycin Y + H2O2
GO:0070530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63-linked polyubiquitin modification-dependent protein binding
RHEA:20266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-proline + O2 => cis-3-hydroxy-L-proline + CO2 + succinate
REACT:R-GGA-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Gallus gallus)
GO:0102376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lupeol 28-oxidase activity
RHEA:38810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:69427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutanoyl-CoA <=> acetone + formyl-CoA
RHEA:21519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopiperitenone <=> piperitenone
GO:0047926	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-bornylpyrophosphate cyclase activity
GO:0047926	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-bornyl-diphosphate lyase (decyclizing)
GO:0047926	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bornyl pyrophosphate synthetase activity
GO:0047926	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bornyl pyrophosphate synthase activity
GO:0047926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranyl-diphosphate cyclase activity
GO:0047926	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bornyl diphosphate synthase activity
RHEA:66626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-8870678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fibrinogen products bind TLR4:LY96 (Mus musculus)
RHEA:53158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Xenopus tropicalis)
RHEA:38377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisanhydrobacterioruberin + 2 H2O => bacterioruberin
REACT:R-SSC-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Sus scrofa)
RHEA:24912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobut-2-enoate + L-cysteine => L,L-cystathionine
RHEA:25215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
REACT:R-DRE-173720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7 translocates to the plasma membrane (Danio rerio)
REACT:R-SPO-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)
REACT:R-XTR-2160884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Xenopus tropicalis)
REACT:R-BTA-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Bos taurus)
REACT:R-HSA-9647680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP1 cleaves GSDMD (Homo sapiens)
REACT:R-HSA-139842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Syk tyrosine kinase (Homo sapiens)
REACT:R-GGA-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Gallus gallus)
REACT:R-GGA-964773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXGR1 binds 2OG (Gallus gallus)
RHEA:46002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tuberculosinyladenosine + diphosphate => adenosine + H(+) + tuberculosinyl diphosphate
REACT:R-HSA-350058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL NCOR corepressor complex (Homo sapiens)
REACT:R-DRE-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Danio rerio)
RHEA:17169	skos:prefLabel	"galactosamine-1-phosphate N-acetyltransferase"
RHEA:17169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactosamine-1-phosphate N-acetyltransferase"
RHEA:17169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate
RHEA:69885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(in) + 2 Na(+)(in) => L-ascorbate(out) + 2 Na(+)(out)
RHEA:21987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + choline <=> adenosine 3',5'-bisphosphate + choline sulfate + H(+)
REACT:R-HSA-9668218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBEA binds DLG3 (Homo sapiens)
GO:0008894	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity
GO:0008894	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine pentaphosphate phosphohydrolase activity
GO:0008894	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity
GO:0008894	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity
GO:0008894	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine pentaphosphate phosphatase activity
GO:0008894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
GO:0008894	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine pentaphosphatase activity
GO:0008894	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pppGpp 5'-phosphohydrolase activity
GO:0008894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity
REACT:R-XTR-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Xenopus tropicalis)
REACT:R-RNO-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Rattus norvegicus)
RHEA:41665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + NAD(+) => chelirubine + NADH
RHEA:49790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glycochenodeoxycholate + H(+) => chenodeoxycholoyl-CoA + glycine
RHEA:60945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + S-adenosyl-L-methionine => H(+) + isorhamnetin + S-adenosyl-L-homocysteine
RHEA:30408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] => oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]
EC:2.4.1.135	skos:altLabel	"glucuronosyltransferase I"
EC:2.4.1.135	skos:altLabel	"uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase"
EC:2.4.1.135	skos:prefLabel	"galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"
EC:2.4.1.135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"
REACT:R-GGA-373047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)
RHEA:55514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Homo sapiens)
REACT:R-BTA-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)
EC:3.3.2.9	skos:altLabel	"arene-oxide hydratase"
EC:3.3.2.9	skos:altLabel	"aryl epoxide hydrase"
EC:3.3.2.9	skos:prefLabel	"microsomal epoxide hydrolase"
EC:3.3.2.9	skos:altLabel	"microsomal oxirane/oxetane hydrolase"
EC:3.3.2.9	skos:altLabel	"microsomal epoxide hydrase"
EC:3.3.2.9	skos:altLabel	"epoxide hydratase"
EC:3.3.2.9	skos:altLabel	"mEH"
EC:3.3.2.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"microsomal epoxide hydrolase"
EC:3.3.2.9	skos:altLabel	"epoxide hydrase"
EC:3.3.2.9	skos:altLabel	"microsomal epoxide hydratase"
EC:3.3.2.9	skos:altLabel	"benzo[a]pyrene-4,5-oxide hydratase"
EC:3.3.2.9	skos:altLabel	"cis-epoxide hydrolase"
RHEA:30125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[ACP] + tetradecanoate => H2O + tetradecanoyl-[ACP]
RHEA:72519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate = 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)
RHEA:29745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine(out) => 2-phenylethylamine(in)
REACT:R-CEL-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Caenorhabditis elegans)
RHEA:71609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + phosphate(in) => (S)-malate(in) + phosphate(out)
REACT:R-BTA-5340251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Bos taurus)
REACT:R-GGA-158721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Gallus gallus)
EC:3.1.3.44	skos:prefLabel	"[acetyl-CoA carboxylase]-phosphatase"
EC:3.1.3.44	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[acetyl-CoA carboxylase]-phosphatase"
RHEA:63594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-GGA-193695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK interacts with TRAF6 (Gallus gallus)
REACT:R-MMU-5696564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP25 deubiquitinates DDX58 (Mus musculus)
REACT:R-SPO-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Schizosaccharomyces pombe)
RHEA:37716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:31865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	friedelin => (S)-2,3-epoxysqualene
REACT:R-CFA-9607304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Canis familiaris)
REACT:R-HSA-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)
REACT:R-DME-1855205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)
RHEA:68510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-SSC-8959510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPHS2 phosphorylates H2Se to form SELP (Sus scrofa)
REACT:R-GGA-416683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA3E binds to PLXND1 (Gallus gallus)
RHEA:51360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-leucine = (9Z)-octadecenoate + L-leucine
RHEA:27700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-galactose 1-phosphate + GDP + H(+) => GDP-beta-L-galactose + phosphate
RHEA:36846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA
REACT:R-HSA-9702607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pexidartinib-resistant FLT3 mutants don't bind pexidartinib (Homo sapiens)
RHEA:54739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine
RHEA:64308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminobutanoate + pyruvate = acetoacetate + L-alanine
RHEA:52896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin = 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate
RHEA:52896	skos:prefLabel	"Ni-sirohydrochlorin a,c-diamide synthase"
RHEA:52896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Ni-sirohydrochlorin a,c-diamide synthase"
RHEA:15260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threonine <=> acetaldehyde + glycine
REACT:R-RNO-8851933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates GAB1 (Rattus norvegicus)
RHEA:40605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O
EC:2.4.1.367	skos:altLabel	"UGTPg100"
EC:2.4.1.367	skos:prefLabel	"ginsenoside 6-O-glucosyltransferase"
EC:2.4.1.367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ginsenoside 6-O-glucosyltransferase"
REACT:R-SPO-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Schizosaccharomyces pombe)
GO:0045522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-26 receptor binding
GO:0045522	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-26 receptor ligand
GO:0045522	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-26
REACT:R-HSA-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Homo sapiens)
REACT:R-XTR-1433428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2 is indirectly recruited to p-KIT through SHP2 (Xenopus tropicalis)
GO:0030368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-17R
GO:0030368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-17 receptor activity
GO:0030368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-17 receptor activity
REACT:R-SSC-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Sus scrofa)
REACT:R-MMU-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
RHEA:40722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione <=> an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)
REACT:R-RNO-5578965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A binds AGO2:miRNA (Rattus norvegicus)
RHEA:72733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose(out) + UMP(in) => UDP-alpha-D-glucose(in) + UMP(out)
RHEA:54971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl phosphate + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate
RHEA:16163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[leghemoglobin] + H(+) + NAD(+) => 2 Fe(III)-[leghemoglobin] + NADH
RHEA:70995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine(out) + L-glutamate(in) = L-cystine(in) + L-glutamate(out)
REACT:R-DRE-77608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of A1CF to stem-looped RNA (Danio rerio)
REACT:R-BTA-9661723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)
RHEA:47681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactosamine 6-phosphate + H2O => D-tagatopyranose 1-phosphate + NH4(+)
RHEA:39748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol(in) => cholesterol(out)
REACT:R-RNO-4085028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE phosphorylates ManNAc to ManNAc-6-P (Rattus norvegicus)
RHEA:37101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O
RHEA:51237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) => GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate
REACT:R-XTR-9756138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Xenopus tropicalis)
REACT:R-XTR-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Xenopus tropicalis)
REACT:R-SSC-4420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 disassociates from VEGFR2 and translocate to PM (Sus scrofa)
RHEA:64185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-tyrosine => (9Z)-octadecenoate + L-tyrosine
REACT:R-MMU-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Mus musculus)
REACT:R-XTR-110351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of SMUG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)
REACT:R-XTR-5692775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Xenopus tropicalis)
RHEA:15985	skos:prefLabel	"formate dehydrogenase"
RHEA:15985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate dehydrogenase"
RHEA:15985	skos:altLabel	"formate dehydrogenase (NAD(+))"
RHEA:15985	skos:altLabel	"NAD(+)-formate dehydrogenase"
RHEA:15985	skos:altLabel	"formic hydrogen-lyase"
RHEA:15985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + NAD(+) = CO2 + NADH
REACT:R-HSA-195739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmitoylation of cysteine residues on M2 in the cis-golgi network (Homo sapiens)
RHEA:32133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + CO2 => (2S)-ethylmalonyl-CoA + H(+)
RHEA:28442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP] = dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]
REACT:R-XTR-2465938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates atROL taken up by Muller cells (Xenopus tropicalis)
REACT:R-HSA-1253319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus (Homo sapiens)
RHEA:50963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine
REACT:R-XTR-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Xenopus tropicalis)
GO:0070697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activin receptor binding
GO:0018849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis,cis-muconate cycloisomerase activity
GO:0018849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis,cis-muconate-lactonizing enzyme
GO:0018849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	muconate cycloisomerase activity
GO:0018849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	muconate lactonizing enzyme I activity
GO:0018849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	muconate lactonizing enzyme activity
GO:0018849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	muconate cycloisomerase I activity
REACT:R-HSA-8953013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 binds E2F8 (Homo sapiens)
RHEA:13472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + thymine <=> 5-methylbarbiturate + AH2 + H(+)
REACT:R-MMU-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Mus musculus)
RHEA:21525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + acetyl-CoA + H2O => (2S)-2-isopropylmalate + CoA + H(+)
RHEA:42988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = cembrene C + diphosphate
RHEA:42988	skos:prefLabel	"cembrene C synthase"
RHEA:42988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cembrene C synthase"
RHEA:33497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-heptaprenyl-sn-glycero-1-phosphate + diphosphate => all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate
REACT:R-HSA-4719448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO3 (Homo sapiens)
REACT:R-DRE-937044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 (Danio rerio)
REACT:R-XTR-6809707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTMR2 (Xenopus tropicalis)
REACT:R-XTR-4551738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO2,3 (Xenopus tropicalis)
RHEA:64850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hex-3-en-1-yl benzoate + CoA => (3Z)-hex-3-en-1-ol + benzoyl-CoA
RHEA:19254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin + H2O => an N-acylsphing-4-enine + H(+) + phosphocholine
RHEA:22533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenedioyl-CoA + H2O => (3S)-hydroxyoctanedioyl-CoA
REACT:R-MMU-140736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Mus musculus)
REACT:R-RNO-433711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-homodimerization of nectins (Rattus norvegicus)
REACT:R-CEL-8853965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Caenorhabditis elegans)
RHEA:31006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> germanicol
REACT:R-BTA-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Bos taurus)
REACT:R-MMU-3640862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase binds AXIN (Mus musculus)
RHEA:43021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L,L-cystathionine => 2-aminoprop-2-enoate + L-homocysteine
REACT:R-DRE-9726875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCNs:cAMP bind SNIs (Danio rerio)
RHEA:28421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + gamma-butyrobetainyl-CoA <=> (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate
RHEA:27285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)
RHEA:66906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cannabichromenate => A + cannabinerolate
REACT:R-HSA-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Homo sapiens)
REACT:R-DRE-198315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IRS recruits PI3K to the plasma membrane and activates it (Danio rerio)
REACT:R-SSC-5607759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIKA2 binds K63polyUb-TRAF6 oligomer (Sus scrofa)
RHEA:54290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]
GO:0022831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	narrow pore, gated channel activity
GO:0022831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ion channels
REACT:R-SSC-1306963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Sus scrofa)
RHEA:71535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6-phosphate(out) + phosphate(in)
REACT:R-CFA-1306957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
REACT:R-SSC-2562564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 processing within TLR4 complex (Sus scrofa)
RHEA:71368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epiandrosterone 3-sulfate(out) + 2 Na(+)(out) => epiandrosterone 3-sulfate(in) + 2 Na(+)(in)
REACT:R-HSA-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Homo sapiens)
RHEA:63535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin I + H2O <=> angiotensin-(1-9) + L-leucine
RHEA:30259	skos:altLabel	"cytochrome bd oxidase"
RHEA:30259	skos:altLabel	"cytochrome aa3-600 oxidase"
RHEA:30259	skos:prefLabel	"menaquinol oxidase (H(+)-transporting)"
RHEA:30259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"menaquinol oxidase (H(+)-transporting)"
RHEA:30259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a menaquinol + O2 = 2 a menaquinone + 2 H2O
REACT:R-DME-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Drosophila melanogaster)
RHEA:58922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-medicarpin + H2O => (3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol
REACT:R-RNO-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Rattus norvegicus)
RHEA:50695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate <=> ADP + alpha-maltose 1-phosphate + H(+)
RHEA:64029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine => H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine
RHEA:38737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol
REACT:R-RNO-73729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of SL1 (Rattus norvegicus)
REACT:R-HSA-9609742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Homo sapiens)
REACT:R-DRE-177920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2 to GAB1 (Danio rerio)
RHEA:56673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-4-coumaroyl-CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH
REACT:R-MMU-9686524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6-PPP6R3 dephosphorylates TERF2 (Mus musculus)
GO:0046422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	VDE
GO:0046422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	violaxanthin:ascorbate oxidoreductase activity
GO:0046422	skos:prefLabel	"violaxanthin de-epoxidase"
GO:0046422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin + 2 L-ascorbate = all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate
GO:0046422	skos:altLabel	"VDE"
GO:0046422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"violaxanthin de-epoxidase"
GO:0046422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	violaxanthin de-epoxidase activity
REACT:R-XTR-381612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1 (Xenopus tropicalis)
RHEA:29511	skos:prefLabel	"valencene synthase"
RHEA:29511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valencene synthase"
RHEA:29511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-valencene + diphosphate
REACT:R-SSC-446862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)
REACT:R-DME-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Drosophila melanogaster)
REACT:R-MMU-9034855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK3 (Mus musculus)
RHEA:21537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA => 3-methyl-(2E)-glutaconyl-CoA + H2O
RHEA:71522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(out) <=> uridine(in)
REACT:R-HSA-1606807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Homo sapiens)
REACT:R-CFA-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Canis familiaris)
RHEA:35168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	minocycline(in) => minocycline(out)
EC:1.2.1.80	skos:prefLabel	"long-chain acyl-[acyl-carrier-protein] reductase"
EC:1.2.1.80	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain acyl-[acyl-carrier-protein] reductase"
EC:1.2.1.80	skos:altLabel	"fatty acyl-[acyl-carrier-protein] reductase"
RHEA:28516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinyl-CoA + AMP + diphosphate => (R)-carnitine + ATP + CoA
REACT:R-MMU-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Mus musculus)
REACT:R-DME-6804468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO2 (Drosophila melanogaster)
REACT:R-CEL-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)
REACT:R-SSC-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Sus scrofa)
RHEA:42278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA => (2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP]
REACT:R-HSA-5687653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)
RHEA:62576	skos:prefLabel	"ABC-type cystine transporter"
RHEA:62576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type cystine transporter"
RHEA:62576	skos:altLabel	"cystine transporting ATPase"
RHEA:62576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-cystine(out) = ADP + H(+) + L-cystine(in) + phosphate
RHEA:62576	skos:altLabel	"cystine ABC transporter"
RHEA:62576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-cystine(out) + H2O = ADP + D-cystine(in) + H(+) + phosphate
RHEA:63822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[aryl-carrier protein] + petrobactin => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)
REACT:R-RNO-112381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Rattus norvegicus)
REACT:R-DRE-9709831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds TBK1 and IRF3 (Danio rerio)
REACT:R-MMU-5692779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S182 MAPKAPK5 phosphorylates FOXO1 (Mus musculus)
REACT:R-BTA-383363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 2 (NK2) binds to nuerokinin A (Bos taurus)
REACT:R-HSA-74615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP (Homo sapiens)
REACT:R-HSA-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Homo sapiens)
REACT:R-GGA-390909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds hist (Gallus gallus)
REACT:R-RNO-2160892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Rattus norvegicus)
GO:0016403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NG,NG-dimethylarginine dimethylaminohydrolase activity
GO:0016403	skos:altLabel	"N(G),N(G)-dimethylarginine dimethylaminohydrolase"
GO:0016403	skos:prefLabel	"dimethylargininase"
GO:0016403	skos:altLabel	"dimethylarginine dimethylaminohydrolase"
GO:0016403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylarginine dimethylaminohydrolase activity
GO:0016403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylargininase activity
GO:0016403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity
GO:0016403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(G),N(G)-dimethylarginine dimethylaminohydrolase activity
GO:0016403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylargininase"
REACT:R-SSC-196126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from cytosol to mitochondrial intermembrane space (Sus scrofa)
REACT:R-DDI-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Dictyostelium discoideum)
GO:0003934	skos:prefLabel	"GTP cyclohydrolase I"
GO:0003934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP 7,8-8,9-dihydrolase activity
GO:0003934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP 8-formylhydrolase activity
GO:0003934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine triphosphate cyclohydrolase activity
GO:0003934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)
GO:0003934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP cyclohydrolase I activity
GO:0003934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GTP cyclohydrolase I"
GO:0003934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroneopterin triphosphate synthase activity
GO:0003934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine triphosphate 8-deformylase activity
GO:0004424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IGP dehydratase activity
GO:0004424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazoleglycerol phosphate dehydratase activity
GO:0004424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazoleglycerol-phosphate dehydratase activity
GO:0004424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]
GO:0004424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity
REACT:R-HSA-432295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI binds Fyn and Lyn (Homo sapiens)
RHEA:33428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl alpha-D-glucosaminide + L-cysteine => bacillithiol + H2O
REACT:R-HSA-9754480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene (Homo sapiens)
EC:3.2.1.181	skos:prefLabel	"galactan endo-beta-1,3-galactanase"
EC:3.2.1.181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactan endo-beta-1,3-galactanase"
EC:3.2.1.181	skos:altLabel	"endo-beta-1,3-galactanase"
REACT:R-DME-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Drosophila melanogaster)
REACT:R-SSC-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Sus scrofa)
RHEA:30304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:45020	skos:prefLabel	"ribosomal protein L3 N(5)-glutamine methyltransferase"
RHEA:45020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribosomal protein L3 N(5)-glutamine methyltransferase"
RHEA:45020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine
RHEA:14093	skos:prefLabel	"tryptophan transaminase"
RHEA:14093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan transaminase"
RHEA:14093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-tryptophan = indole-3-pyruvate + L-glutamate
RHEA:14093	skos:altLabel	"tryptophan aminotransferase"
EC:3.4.21.86	skos:prefLabel	"limulus clotting enzyme"
EC:3.4.21.86	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limulus clotting enzyme"
REACT:R-CEL-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)
REACT:R-CFA-190263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3b binds to FGF (Canis familiaris)
RHEA:58224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide
GO:0052829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Homo sapiens)
GO:0052829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4-trisphosphate 1-phosphatase activity
REACT:R-MMU-6810643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPPIN protein complex binds bacteria (Mus musculus)
REACT:R-DME-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)
RHEA:44545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(out) + ATP + H2O => a fatty acid(in) + ADP + H(+) + phosphate
RHEA:68585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-tryptophan(out) => ADP + H(+) + L-tryptophan(in) + phosphate
REACT:R-HSA-2172126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAP12 interacts with NKG2C (Homo sapiens)
RHEA:52071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)
REACT:R-BTA-183122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3b-bound Factor B (Bos taurus)
RHEA:48926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E))
REACT:R-DDI-2029460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates LIMK1 (Dictyostelium discoideum)
REACT:R-MMU-212614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamine transport from astrocytes (Mus musculus)
RHEA:15600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Fe(III)-siderophore(out) + ATP + H2O <=> a Fe(III)-siderophore(in) + ADP + H(+) + phosphate
REACT:R-SSC-2404193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1R phosphorylates SHC1 (Sus scrofa)
RHEA:51443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
REACT:R-HSA-114560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adhesion of integrin alphaIIbbeta3 to fibrin network (Homo sapiens)
RHEA:14207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anserine + H(+) + S-adenosyl-L-homocysteine => carnosine + S-adenosyl-L-methionine
RHEA:33988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate => diphosphate + neoabietadiene
REACT:R-HSA-212005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)
REACT:R-RNO-6804724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates phosphorylated MDM4 (Rattus norvegicus)
RHEA:61565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tetracycline + H(+) + NADPH + O2 => a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)
REACT:R-HSA-9029561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to the ABCA1 promoter (Homo sapiens)
RHEA:17744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADH
REACT:R-SSC-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Sus scrofa)
RHEA:70976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine(out) + L-aspartate(in) => 3-sulfino-L-alanine(in) + L-aspartate(out)
RHEA:63831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + vanillin <=> pyruvate + vanillylamine
RHEA:53541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine
REACT:R-HSA-6807826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDHAL6B reduces PYR to LACT (Homo sapiens)
GO:0004310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity
GO:0004310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	presqualene synthase activity
GO:0004310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesyl-diphosphate farnesyltransferase activity
GO:0004310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	presqualene-diphosphate synthase activity
REACT:R-BTA-982810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation (Bos taurus)
REACT:R-HSA-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Homo sapiens)
RHEA:45175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-8852324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds PLK1 (Homo sapiens)
EC:2.7.4.9	skos:altLabel	"thymidylate kinase"
EC:2.7.4.9	skos:altLabel	"TMPK"
EC:2.7.4.9	skos:prefLabel	"dTMP kinase"
EC:2.7.4.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTMP kinase"
EC:2.7.4.9	skos:altLabel	"thymidylic acid kinase"
RHEA:58010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg1 + H(+) + UDP => (20S)-ginsenoside F1 + UDP-alpha-D-glucose
RHEA:13568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol <=> 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)
REACT:R-BTA-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Bos taurus)
REACT:R-SSC-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)
REACT:R-BTA-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Bos taurus)
RHEA:42833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H(+) + pyruvate => (S)-3-acetyloctanal + CO2
REACT:R-CFA-448603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33:IL1RL1 binds IL1RAP-1 (Canis familiaris)
RHEA:59303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + firefly D-luciferin <=> adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)
REACT:R-DRE-3215406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds WDR77 (Danio rerio)
GO:0030798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity
GO:0030798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-aconitate 2-methyltransferase activity
REACT:R-HSA-422454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polysialylation of NCAM1 (Homo sapiens)
REACT:R-HSA-8944220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIII (Homo sapiens)
REACT:R-PFA-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Plasmodium falciparum)
REACT:R-SSC-2168889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin-related Protein binds Hemoglobin (Sus scrofa)
RHEA:42769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH
REACT:R-CFA-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Canis familiaris)
RHEA:18303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + GMP + 2 H(+) => ATP + NH4(+) + XMP
REACT:R-XTR-163843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-GAS6 to GAS6 (Xenopus tropicalis)
REACT:R-BTA-114552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate G12/13 (Bos taurus)
REACT:R-HSA-376140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ena/VASP proteins bind ROBO1:SLIT2 complex (Homo sapiens)
REACT:R-CFA-5251955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Canis familiaris)
REACT:R-DDI-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
RHEA:58651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifamycin SV hemiaminal <=> H(+) + rifamycin SV ortho-naphthoquinone carboxamide
REACT:R-DRE-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Danio rerio)
REACT:R-GGA-3134946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 ubiquitination by TRIM21 (Gallus gallus)
REACT:R-XTR-2471621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin degradation by cathepsins (Xenopus tropicalis)
REACT:R-RNO-9624120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK2 (Rattus norvegicus)
RHEA:71355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) = 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)
REACT:R-DRE-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Danio rerio)
RHEA:20702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + lipid IVA (E. coli) => ATP + lipid A disaccharide (E. coli)
REACT:R-MMU-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Mus musculus)
REACT:R-DRE-5638141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Danio rerio)
REACT:R-SSC-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Sus scrofa)
RHEA:33843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoylsphinganine = sphinganine + tetracosanoate
REACT:R-GGA-202168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ZAP-70 by Lck (Gallus gallus)
RHEA:17357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'
RHEA:17357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiol oxidase"
RHEA:17357	skos:prefLabel	"thiol oxidase"
RHEA:17357	skos:altLabel	"sulfhydryl oxidase"
REACT:R-HSA-9693009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of AMH in testis differentiation (Homo sapiens)
RHEA:37221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + AH2 + NH4(+) => A + D-valine + H2O
REACT:R-SSC-9686524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6-PPP6R3 dephosphorylates TERF2 (Sus scrofa)
REACT:R-DME-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Drosophila melanogaster)
EC:1.11.2.-	skos:prefLabel	"With H2O2 as acceptor, one oxygen atom of which is incorporated into the product"
EC:1.11.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With H2O2 as acceptor, one oxygen atom of which is incorporated into the product"
RHEA:37925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2
REACT:R-HSA-9018858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Homo sapiens)
GO:0015438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	teichoic-acid ABC transporter
GO:0015438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type teichoic-acid transporter
GO:0015438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type teichoic acid transporter activity
GO:0015438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled teichoic acid transmembrane transporter activity
GO:0015438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent teichoic acid transmembrane transporter activity
GO:0015438	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	teichoic acid transmembrane transporter activity
GO:0015438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	teichoic-acid-transporting ATPase activity
RHEA:50958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine
GO:0005139	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-7
GO:0005139	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-7 receptor ligand
GO:0005139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-7 receptor binding
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acyl-acyl carrier protein synthetase
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-fatty-acid-[acyl-carrier-protein] ligase activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-fatty-acid-acyl-carrier-protein ligase activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-proteinsynthetase activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-fatty-acid-[acyl-carrier protein] ligase activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-fatty-acid-ACP ligase activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein synthetase activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-ACP synthetase activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acid [acyl-carrier-protein] ligase activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	stearoyl-ACP synthetase activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-[acyl-carrier-protein] synthetase activity
GO:0008922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acid-[acyl-carrier-protein] ligase activity
REACT:R-MMU-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Mus musculus)
REACT:R-CFA-389632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Canis familiaris)
RHEA:18336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + oleandomycin <=> ADP + H(+) + oleandomycin 2'-O-phosphate
REACT:R-CFA-6794355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 binds mGluR1a,5 (Canis familiaris)
REACT:R-CEL-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Caenorhabditis elegans)
RHEA:65595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethyluric acid monooxygenase activity
REACT:R-DME-190256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to FGF (Drosophila melanogaster)
RHEA:24549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-acyl-L-lysine + H2O => a carboxylate + L-lysine
REACT:R-SSC-5229111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 transports APP from trans-Golgi network to endosome lumen (Sus scrofa)
RHEA:23232	skos:prefLabel	"hydrazine dehydrogenase"
RHEA:23232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrazine dehydrogenase"
RHEA:23232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome c] + hydrazine = 4 Fe(II)-[cytochrome c] + 4 H(+) + N2
RHEA:37488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CEL-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Caenorhabditis elegans)
REACT:R-SSC-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Sus scrofa)
GO:0032565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP binding
REACT:R-SSC-977605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H displaces Bb (Sus scrofa)
RHEA:58377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decan-1-ol + NADP(+) => decanal + H(+) + NADPH
REACT:R-DDI-8948775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKRN1 polyubiquitinates PTEN (Dictyostelium discoideum)
REACT:R-HSA-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Homo sapiens)
RHEA:41739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) <=> adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)
REACT:R-GGA-5617816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A  (Gallus gallus)
REACT:R-CEL-1602374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Caenorhabditis elegans)
RHEA:44163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 6-phosphate + H2O <=> myo-inositol + phosphate
RHEA:39506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)
RHEA:35714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + succinyl-CoA <=> acetyl-CoA + succinate
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADH-NADP-transhydrogenase
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADPH-NAD oxidoreductase
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H+-thase
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyridine nucleotide transhydrogenase activity
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:NAD+ oxidoreductase (B-specific)
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nicotinamide adenine dinucleotide (phosphate) transhydrogenase
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P) transhydrogenase (B-specific) activity
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD transhydrogenase
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	non-energy-linked transhydrogenase activity
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADPH:NAD+ transhydrogenase
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)+ transhydrogenase (B-specific) activity
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nicotinamide nucleotide transhydrogenase activity
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyridine nucleotide transferase
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADH transhydrogenase
GO:0003957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADPH-NAD transhydrogenase
GO:0000268	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peroxisome targeting signal receptor
GO:0000268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTS binding
GO:0000268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisome targeting sequence binding
GO:0000268	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PTS receptor
REACT:R-CFA-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Canis familiaris)
REACT:R-DRE-9022314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates MECP2 (Danio rerio)
RHEA:13412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanine + 2 NADP(+) <=> 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH
RHEA:35498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-aminobenzoyl)-L-glutamate <=> 4-aminobenzoate + L-glutamate
RHEA:55078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylsulfanylpropanal + CO2 => 4-methylsulfanyl-2-oxobutanoate + H(+)
REACT:R-DME-4332358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CaM and CAMK2 autophosphorylation (Drosophila melanogaster)
REACT:R-SSC-158959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Sus scrofa)
RHEA:52324	skos:prefLabel	"nitric-oxide synthase (flavodoxin)"
RHEA:52324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitric-oxide synthase (flavodoxin)"
RHEA:52324	skos:altLabel	"nitric oxide synthetase"
RHEA:52324	skos:altLabel	"NO synthase"
RHEA:52324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-arginine + 4 O2 + 3 reduced [flavodoxin] = 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]
REACT:R-SSC-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Sus scrofa)
RHEA:24541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-glucose => AH2 + D-glucono-1,5-lactone
RHEA:61096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-acetaldehyde + O2 <=> (indol-3-yl)acetate + H(+) + H2O2
RHEA:60440	skos:prefLabel	"methyl acetate hydrolase"
RHEA:60440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methyl acetate hydrolase"
RHEA:60440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl acetate = acetate + H(+) + methanol
EC:3.2.2.20	skos:altLabel	"DNA glycosidase I"
EC:3.2.2.20	skos:prefLabel	"DNA-3-methyladenine glycosylase I"
EC:3.2.2.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA-3-methyladenine glycosylase I"
EC:3.2.2.20	skos:altLabel	"DNA-3-methyladenine glycosidase I"
REACT:R-DRE-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Danio rerio)
RHEA:23822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + H2O => GDP-alpha-D-mannose
RHEA:17273	skos:prefLabel	"4-hydroxyphenylacetaldehyde dehydrogenase"
RHEA:17273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) = 4-hydroxyphenylacetate + 2 H(+) + NADH
RHEA:17273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylacetaldehyde dehydrogenase"
REACT:R-SSC-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Sus scrofa)
REACT:R-XTR-5687673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN recruits LIG3:XRCC1 to MMEJ sites (Xenopus tropicalis)
RHEA:47820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)
GO:0051392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA cytidine N-acetyltransferase activity
GO:0051392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA N-acetyltransferase activity
REACT:R-HSA-8985091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAS3 produces oligoadenylates (Homo sapiens)
REACT:R-CEL-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
REACT:R-MMU-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Mus musculus)
REACT:R-XTR-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Xenopus tropicalis)
GO:0051719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates
RHEA:12646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] => (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DRE-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Danio rerio)
RHEA:48377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)
REACT:R-HSA-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)
REACT:R-CFA-8936851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHRR binds ARNT (Canis familiaris)
RHEA:65198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine => H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine
REACT:R-CFA-2046180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSPG is secreted from the cell (Canis familiaris)
REACT:R-MMU-193727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
REACT:R-HSA-2161692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 (Homo sapiens)
REACT:R-RNO-1602488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by plasmin and trypsin (Rattus norvegicus)
REACT:R-XTR-8862771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G2A binds bacterial phospholipids (Xenopus tropicalis)
RHEA:45393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-5660980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S276-RELA binds RELB (Homo sapiens)
REACT:R-DRE-873951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1:HSP90 binds inactive NLRP3 (Danio rerio)
RHEA:28466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine(in) = pyridoxamine(out)
RHEA:67693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + hexadecanedioate(in) => ADP + H(+) + hexadecanedioate(out) + phosphate
RHEA:41972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) = CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)
RHEA:15541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIMBOA + UDP-alpha-D-glucose = DIMBOA beta-D-glucoside + H(+) + UDP
REACT:R-SSC-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Sus scrofa)
REACT:R-HSA-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Homo sapiens)
REACT:R-BTA-6805285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates TP53 (Bos taurus)
RHEA:55008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 = (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)
REACT:R-CFA-5668984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 or PAK2 phosphorylates MYLK (Canis familiaris)
REACT:R-MMU-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)
REACT:R-HSA-8858270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HILPDA binds lipid droplets (Homo sapiens)
REACT:R-HSA-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Homo sapiens)
RHEA:61577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) => (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH
RHEA:59727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaono-1,5-lactone + H2O <=> D-maltoheptaonate + H(+)
REACT:R-HSA-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)
EC:3.4.24.55	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pitrilysin"
EC:3.4.24.55	skos:altLabel	"protease III"
EC:3.4.24.55	skos:altLabel	"protease Pi"
EC:3.4.24.55	skos:prefLabel	"pitrilysin"
REACT:R-DRE-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Danio rerio)
RHEA:50932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
RHEA:37857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA
EC:5.3.99.-	skos:prefLabel	"Other intramolecular oxidoreductases"
EC:5.3.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other intramolecular oxidoreductases"
RHEA:18546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-arabinonate => glycolaldehyde + pyruvate
REACT:R-GGA-936963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization (Gallus gallus)
REACT:R-MMU-163090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation Of The Telomeric Chromosome End (Mus musculus)
GO:0035730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-nitrosoglutathione binding
GO:0035730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSNO binding
GO:0071967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide core heptosyltransferase activity
GO:0071967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS core heptosyltransferase activity
REACT:R-HSA-9710306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME expression mediated by TP53, TP63 (Homo sapiens)
REACT:R-CEL-191784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA Cap hypermethylation (Caenorhabditis elegans)
RHEA:16072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + H(+) + H2O <=> NH4(+) + uridine
REACT:R-HSA-977317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Homo sapiens)
RHEA:36806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2,3-dihydrogenistein <=> genistein + H(+) + H2O
REACT:R-BTA-4655431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOyation of DNMT1 with SUMO1 (Bos taurus)
REACT:R-XTR-112265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Xenopus tropicalis)
REACT:R-RNO-350319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of vimentin at IDVD (259) (Rattus norvegicus)
REACT:R-CEL-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Caenorhabditis elegans)
RHEA:25896	skos:altLabel	"malonate carboxy-lyase (biotin-independent)"
RHEA:25896	skos:prefLabel	"biotin-independent malonate decarboxylase"
RHEA:25896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonate = acetate + CO2
RHEA:25896	skos:altLabel	"MDC"
RHEA:25896	skos:altLabel	"malonate decarboxylase"
RHEA:25896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biotin-independent malonate decarboxylase"
RHEA:21153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline => cis-4-hydroxy-D-proline
REACT:R-HSA-2245218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates PHF8 (Homo sapiens)
REACT:R-CFA-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Canis familiaris)
REACT:R-SSC-202500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of IKK complex (Sus scrofa)
REACT:R-DME-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Drosophila melanogaster)
RHEA:48038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine => globoside Gb4Cer (d18:1(4E)) + H2O
REACT:R-XTR-9014812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBOs bind keratan sulfate (Xenopus tropicalis)
RHEA:53901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[myosin light chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]
REACT:R-BTA-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Bos taurus)
REACT:R-SCE-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Saccharomyces cerevisiae)
REACT:R-SSC-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Sus scrofa)
GO:0045158	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome b6
GO:0045158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome
GO:0045158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome b/b6
GO:0045158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity
GO:0045158	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome f
REACT:R-BTA-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Bos taurus)
RHEA:22318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP => 13-hydroxydocosanoate + UDP-alpha-D-glucose
REACT:R-SSC-5696872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates Ub-MOM proteins (Sus scrofa)
RHEA:72976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 indole-3-pyruvate => 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)
RHEA:21177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH
REACT:R-CEL-9036987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Caenorhabditis elegans)
EC:3.4.21.79	skos:prefLabel	"granzyme B"
EC:3.4.21.79	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"granzyme B"
EC:3.4.21.79	skos:altLabel	"cytotoxic t-lymphocyte proteinase 2"
REACT:R-GGA-2514867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Gallus gallus)
REACT:R-HSA-8877360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the IFNG promoter (Homo sapiens)
GO:0047608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylindoxyl:oxygen oxidoreductase activity
GO:0047608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylindoxyl oxidase activity
REACT:R-HSA-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Homo sapiens)
RHEA:61970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-BTA-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Bos taurus)
REACT:R-BTA-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Bos taurus)
REACT:R-GGA-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Gallus gallus)
REACT:R-MMU-8866321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL binds APOC1 and APOC4 (Mus musculus)
GO:0102766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naringenin 7-O-methyltransferase activity
REACT:R-MMU-8849082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 stimulates RHOA GTPase activity (Mus musculus)
RHEA:17936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-6782820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates SUDS3 (Rattus norvegicus)
REACT:R-HSA-452750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FOXD3 (Homo sapiens)
REACT:R-HSA-374787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)
REACT:R-XTR-2301205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 monomethylates histone H4 (Xenopus tropicalis)
RHEA:55333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydroxyflavone + S-adenosyl-L-methionine => a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine
EC:1.1.1.195	skos:prefLabel	"cinnamyl-alcohol dehydrogenase"
EC:1.1.1.195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cinnamyl-alcohol dehydrogenase"
EC:1.1.1.195	skos:altLabel	"CAD"
GO:0031890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VIP receptor binding
GO:0031890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vasoactive intestinal polypeptide receptor binding
GO:0031890	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vasoactive intestinal polypeptide receptor ligand
GO:0047524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxysteroid epimerase activity
GO:0047524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16-hydroxysteroid 16-epimerase activity
REACT:R-CEL-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Caenorhabditis elegans)
GO:0140545	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein disaggregase activity
GO:0140545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent protein disaggregase activity
GO:0140545	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein unfoldase activity
REACT:R-HSA-9033529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves ACAA1 (Homo sapiens)
REACT:R-CFA-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Canis familiaris)
REACT:R-BTA-5654600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
REACT:R-GGA-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Gallus gallus)
RHEA:56992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = (+)-costunolide + H2O
RHEA:18904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-benzyloxycarbonyl-L-leucine <=> benzyl alcohol + CO2 + L-leucine
REACT:R-CFA-5213466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is phosphorylated (Canis familiaris)
RHEA:51450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Mus musculus)
GO:0034851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity
RHEA:31548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate => 15-cis-4,4'-diapophytoene + 2 diphosphate
REACT:R-RNO-2514790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by MMP14 (Rattus norvegicus)
RHEA:58242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + L-cysteinyl-[protein] => H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]
REACT:R-RNO-448632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimerizes (Rattus norvegicus)
REACT:R-SSC-6783530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gp130:JAKs bind CNTFR (Sus scrofa)
REACT:R-HSA-373875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Homo sapiens)
RHEA:42652	skos:prefLabel	"diphthine methyl ester synthase"
RHEA:42652	skos:altLabel	"diphthine methyltransferase"
RHEA:42652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine
RHEA:42652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diphthine methyl ester synthase"
REACT:R-DME-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)
REACT:R-HSA-560517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
REACT:R-DME-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Drosophila melanogaster)
REACT:R-RNO-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Rattus norvegicus)
REACT:R-DRE-1482887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Danio rerio)
REACT:R-MMU-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Mus musculus)
RHEA:40803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADPH
RHEA:41821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:10379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Cu(2+)(in) + H2O <=> ADP + Cu(2+)(out) + H(+) + phosphate
REACT:R-MMU-141026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor Va to factor Vi intermediate form (Mus musculus)
REACT:R-DME-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Drosophila melanogaster)
REACT:R-MMU-451056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Microtubule-independent trafficking of connexons to the plasma membrane (Mus musculus)
RHEA:53500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
RHEA:44837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose => globoside NOR2 (d18:1(4E)) + H(+) + UDP
RHEA:41642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA
REACT:R-CEL-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)
RHEA:53302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-carbamoyl-D-methionine => D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O
REACT:R-CFA-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Canis familiaris)
RHEA:12776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + proclavaminate <=> CO2 + dihydroclavaminate + H2O + succinate
REACT:R-DRE-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Danio rerio)
RHEA:55285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + tetradecanoyl-CoA => all-trans-retinyl tetradecanoate + CoA
RHEA:34085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3S)-3-hydroxyacyl-CoA => a (3R)-3-hydroxyacyl-CoA
GO:0008516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexose uniporter activity
REACT:R-RNO-8862380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B13 binds lipid droplets (Rattus norvegicus)
RHEA:18031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + carbamoyl phosphate + 2 H(+) + phosphate => 2 ATP + hydrogencarbonate + NH4(+)
RHEA:32793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ectoine(out) => L-ectoine(in)
RHEA:15775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dihydroxyacetone phosphate + H(+) => ATP + dihydroxyacetone
REACT:R-RNO-1169406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host proteins (Rattus norvegicus)
REACT:R-DME-8934742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRMT1 (Drosophila melanogaster)
REACT:R-CFA-8852019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET bound PI3K generates PIP3 (Canis familiaris)
REACT:R-HSA-170991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 autophosphorylates (Homo sapiens)
REACT:R-RNO-1022129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)
RHEA:29038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamate(out) <=> ADP + H(+) + L-glutamate(in) + phosphate
REACT:R-DRE-6797653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMGDH:FAD oxidatively demethylates DMGLY to SARC (Danio rerio)
REACT:R-DDI-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Dictyostelium discoideum)
RHEA:57524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)
RHEA:20978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H(+) + H2O2 + nitrite => a primary nitroalkane + H2O + O2
REACT:R-HSA-3878123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of SAHF formation (Homo sapiens)
REACT:R-RNO-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Rattus norvegicus)
REACT:R-MMU-5362525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1,C1 4-hydroxylate atRA (Mus musculus)
REACT:R-HSA-8848414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds CDKN1B (Homo sapiens)
REACT:R-HSA-9624033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of HCMV DNA Replication (Homo sapiens)
RHEA:22087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate
RHEA:63818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine
REACT:R-XTR-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)
GO:0106318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methane monooxygenase NADPH activity
GO:0106318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methane + NADPH + O2 = H2O + methanol + NADP(+)
RHEA:62543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain <=> dihydroouabain + 2 Fe(III)-[cytochrome c]
REACT:R-RNO-5654631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PPTN11 (Rattus norvegicus)
REACT:R-DME-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Drosophila melanogaster)
REACT:R-XTR-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-CFA-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
RHEA:33628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + decanoate => AMP + decanoyl-CoA + diphosphate
GO:0018621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-sulfobenzoate 3,4-dioxygenase system
GO:0018621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulfobenzoate 3,4-dioxygenase activity
GO:0018621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-sulfobenzoate dioxygenase activity
GO:0018621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulphobenzoate 3,4-dioxygenase activity
GO:0018621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)
GO:1905575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 binding
REACT:R-DRE-194518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoA is activated by nucleotide exchange and inhibits axonal growth (Danio rerio)
RHEA:22046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + 2 H(+)(out) + K(+)(in) + phosphate => ATP + H(+)(in) + H2O + K(+)(out)
REACT:R-DRE-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Danio rerio)
GO:0050280	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-O-methyl-myo-inositol:NAD+ oxidoreductase activity
GO:0050280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequoyitol dehydrogenase activity
RHEA:17328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA <=> (S)-2-succinylamino-6-oxoheptanedioate + CoA
RHEA:43868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)
REACT:R-GGA-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Gallus gallus)
REACT:R-SSC-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Sus scrofa)
REACT:R-GGA-5686074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Gallus gallus)
RHEA:67429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)
RHEA:23820	skos:altLabel	"GDP-D-mannose 4,6-dehydratase"
RHEA:23820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-mannose 4,6-dehydratase"
RHEA:23820	skos:prefLabel	"GDP-mannose 4,6-dehydratase"
RHEA:23820	skos:altLabel	"guanosine diphosphomannose 4,6-dehydratase"
RHEA:23820	skos:altLabel	"GDP-D-mannose dehydratase"
RHEA:23820	skos:altLabel	"guanosine diphosphomannose oxidoreductase"
RHEA:23820	skos:altLabel	"guanosine 5'-diphosphate-D-mannose oxidoreductase"
RHEA:23820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O
RHEA:54586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine => a guanosine in 18S rRNA + S-adenosyl-L-methionine
RHEA:47745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylphylloquinone + H(+) + NADPH => demethylphylloquinol + NADP(+)
RHEA:63842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + tert-butanol => [thioredoxin]-dithiol + tert-butyl hydroperoxide
REACT:R-MMU-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Mus musculus)
RHEA:15992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH
RHEA:34656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + 2 S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-XTR-9638078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from keratan sulfate (Xenopus tropicalis)
REACT:R-BTA-428262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Bos taurus)
GO:0033785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alpha,beta-D-heptose 7-phosphate 1-kinase activity
GO:0033785	skos:altLabel	"D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase"
GO:0033785	skos:prefLabel	"D-glycero-beta-D-manno-heptose-7-phosphate kinase"
GO:0033785	skos:altLabel	"HldE1 heptokinase"
GO:0033785	skos:altLabel	"heptose 7-phosphate kinase"
GO:0033785	skos:altLabel	"D-beta-D-heptose-7-phosphate kinase"
GO:0033785	skos:altLabel	"glycero-manno-heptose 7-phosphate kinase"
GO:0033785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glycero-beta-D-manno-heptose-7-phosphate kinase"
GO:0033785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptose 7-phosphate kinase activity
GO:0033785	skos:altLabel	"D-beta-D-heptose 7-phosphotransferase"
GO:0033785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)
RHEA:22398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolaldehyde + guaiacol + H2O + vanillin => 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2
REACT:R-BTA-71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer reduces PYR to LACT (Bos taurus)
REACT:R-MMU-211191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF with alpha:beta importin (Mus musculus)
GO:0008017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	microtubule severing activity
GO:0008017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule binding
GO:0008017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	microtubule/chromatin interaction
GO:0008017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs (Homo sapiens)
REACT:R-HSA-5623521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
REACT:R-DME-73646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Drosophila melanogaster)
RHEA:38524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)
REACT:R-DRE-4332363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation and activation of CAMK2 (Danio rerio)
GO:0031964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carcinine hydrolase activity
GO:0031964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-histamine hydrolase activity
RHEA:35336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isopentadecanoyl-CoA + malonyl-CoA => 3-oxoisoheptadecanoyl-CoA + CO2 + CoA
RHEA:29074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + formate + H(+) <=> a ubiquinol + CO2
EC:6.3.1.-	skos:prefLabel	"Acid--ammonia (or amine) ligases (amide synthases)"
EC:6.3.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acid--ammonia (or amine) ligases (amide synthases)"
REACT:R-RNO-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Rattus norvegicus)
REACT:R-HSA-3325546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CD320 does not transport extracellular TCII:Cbl to endosome (Homo sapiens)
REACT:R-CFA-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Canis familiaris)
REACT:R-SSC-5651789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to POLB ligates SSB (Sus scrofa)
RHEA:12574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + ADP + H(+) + phosphate => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP
RHEA:42601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + prostaglandin G2 => A + H2O + prostaglandin H2
RHEA:63998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
REACT:R-CFA-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Canis familiaris)
REACT:R-SSC-109387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Sus scrofa)
GO:0016621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinnamoyl-CoA reductase activity
GO:0016621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feruloyl-CoA reductase activity
GO:0016621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferulyl-CoA reductase activity
GO:0016621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feruloyl coenzyme A reductase activity
GO:0016621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamoyl-coenzyme A reductase activity
GO:0016621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxycinnamoyl coenzyme A reductase activity
GO:0016621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamaldehyde + CoA + NADP(+) = (E)-cinnamoyl-CoA + H(+) + NADPH
GO:0016621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)
GO:0016621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinnamoyl CoA reductase activity
GO:0016621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnamoyl-CoA:NADPH reductase activity
RHEA:19435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + ADP + H(+) => ATP + D-gluconate
REACT:R-HSA-352136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Homo sapiens)
REACT:R-RNO-75825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of Cyclin D1 (Rattus norvegicus)
RHEA:25704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Mus musculus)
REACT:R-HSA-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Homo sapiens)
RHEA:61978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine
RHEA:21880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + oxalate = 2 CO2 + H2O2
RHEA:21880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxalate oxidase"
RHEA:21880	skos:prefLabel	"oxalate oxidase"
RHEA:56536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA
REACT:R-MMU-199144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin 2 binds CD226 (Mus musculus)
RHEA:54747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9603984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Mus musculus)
RHEA:70373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-decanoyl-3-oxosphinganine => 3-oxosphinganine + decanoyl-CoA
GO:0004912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-3 receptor activity
GO:0004912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-3R
GO:0004912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-3 receptor activity
REACT:R-HSA-8943959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP9 cleave SCUBE3 (Homo sapiens)
REACT:R-CFA-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Canis familiaris)
GO:0050397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Watasenia-luciferin 2-monooxygenase activity
GO:0050397	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	luciferase activity
GO:0050397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Watasenia-luciferin 2-monooxygenase"
GO:0050397	skos:altLabel	"Watasenia-type luciferase"
GO:0050397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + Watasenia luciferin = CO2 + hnu + oxidized Watasenia luciferin
GO:0050397	skos:altLabel	"luciferase"
GO:0050397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Watasenia-type luciferase activity
GO:0050397	skos:prefLabel	"Watasenia-luciferin 2-monooxygenase"
GO:0050397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)
REACT:R-BTA-2161890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)
REACT:R-HSA-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)
REACT:R-GGA-8938217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SWI/SNF complex (Gallus gallus)
REACT:R-HSA-5213464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is phosphorylated (Homo sapiens)
REACT:R-CFA-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Canis familiaris)
REACT:R-RNO-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)
GO:0015413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nickel ABC transporter
GO:0015413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nickel transporting ATPase activity
GO:0015413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nickel-transporting ATPase activity
GO:0015413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nickel ABC transporter activity
GO:0015413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nickel porter activity
GO:0015413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent nickel transmembrane transporter activity
GO:0015413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled nickel transmembrane transporter activity
GO:0015413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type nickel transporter activity
GO:0030563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA 2'-O-ribose methylation guide activity
GO:0051920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX activity
GO:0051920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxiredoxin activity
GO:0051920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prx activity
RHEA:16278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-acetaldehyde + O2 => (indol-3-yl)acetate + H(+) + H2O2
RHEA:46133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADPH + O2 => 25-hydroxycholesterol + H2O + NADP(+)
RHEA:48548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol
RHEA:48548	skos:prefLabel	"protein phosphatase methylesterase-1"
RHEA:48548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein phosphatase methylesterase-1"
RHEA:26307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomuconate 6-semialdehyde => 2-aminophenol + O2
RHEA:71382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) <=> D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)
RHEA:33571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + methanol = AH2 + formaldehyde
RHEA:33571	skos:altLabel	"nicotinoprotein methanol dehydrogenase"
RHEA:33571	skos:altLabel	"NDMA-dependent methanol dehydrogenase"
RHEA:33571	skos:prefLabel	"methanol dehydrogenase (nicotinoprotein)"
RHEA:33571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methanol dehydrogenase (nicotinoprotein)"
RHEA:38691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)
REACT:R-BTA-165708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated 4EBP1 from eIF4E (Bos taurus)
REACT:R-HSA-9017120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IK1 binds the PTCRA gene promoter (Homo sapiens)
RHEA:13893	skos:altLabel	"AP3A hydrolase"
RHEA:13893	skos:altLabel	"dinucleosidetriphosphatase"
RHEA:13893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bis(5'-adenosyl)-triphosphatase"
RHEA:13893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+)
RHEA:13893	skos:altLabel	"AP3Aase"
RHEA:13893	skos:prefLabel	"bis(5'-adenosyl)-triphosphatase"
RHEA:13893	skos:altLabel	"diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase"
REACT:R-RNO-5676595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAFs bind RANK:RANKL (Rattus norvegicus)
GO:0031693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1D adrenergic receptor binding
GO:0031693	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-1D adrenergic receptor ligand
REACT:R-MMU-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Mus musculus)
GO:0102399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity
REACT:R-XTR-5617828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIP11:IFT20 dissociates (Xenopus tropicalis)
REACT:R-SSC-9603983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeX to form LeY (Sus scrofa)
REACT:R-BTA-9750001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Bos taurus)
RHEA:68784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = diphosphate + gamma-curcumene
REACT:R-DME-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)
RHEA:46557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 => 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:44238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol
REACT:R-GGA-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Gallus gallus)
REACT:R-MMU-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Mus musculus)
REACT:R-SPO-200423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Schizosaccharomyces pombe)
REACT:R-RNO-193665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYD88 dissociates (Rattus norvegicus)
RHEA:61910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AMP + asperphenamate + 2 diphosphate + H(+) => 2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol
RHEA:38640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
RHEA:23218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2
RHEA:48755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + validamycin A <=> CO2 + H(+) + succinate + validamycin B
REACT:R-XTR-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Xenopus tropicalis)
GO:0070463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin-activated ATPase activity
GO:0070463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin-dependent ATPase activity
REACT:R-DRE-422017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase decanoylates Proghrelin (Danio rerio)
RHEA:61277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-ornithine + O2 => 5-amino-2-oxopentanoate + H2O2 + NH4(+)
RHEA:52601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine + propanoyl-CoA => CoA + H(+) + N-propanoyl-L-methioninate
REACT:R-HSA-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
RHEA:61553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-2395257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-hydroxylysino-norleucine cross-links (Canis familiaris)
RHEA:35437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP => cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose
REACT:R-CFA-193460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Canis familiaris)
GO:0043336	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TelN
GO:0043336	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ResT
GO:0043336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	site-specific telomere resolvase activity
RHEA:15041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis-D-fructose 2',1:2,1'-dianhydride + H2O = inulobiose
GO:0140926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine transmembrane transporter activity
REACT:R-DME-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
REACT:R-DDI-1606583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Dictyostelium discoideum)
REACT:R-BTA-4546387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VDR with SUMO2 (Bos taurus)
REACT:R-GGA-2396561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GADS:SLP-76 to p-5Y-LAT (Gallus gallus)
REACT:R-RNO-5618085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Rattus norvegicus)
REACT:R-CFA-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Canis familiaris)
RHEA:60518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophan => L-tryptophan
REACT:R-DRE-159790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Danio rerio)
REACT:R-DRE-444498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin-releasing hormone receptor binds thyrotropin (Danio rerio)
REACT:R-BTA-8985201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL (Bos taurus)
RHEA:70292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-aminophenyl)-3-oxopropanal => H2O + quinolin-4-ol
RHEA:56494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => hederagenin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-350901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is organified (Canis familiaris)
REACT:R-BTA-2534378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hv1 Mediated H+ Permeability (Bos taurus)
REACT:R-CEL-372519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcCho is hydrolyzed to Cho and acetate by ACHE (Caenorhabditis elegans)
RHEA:70371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + decanoyl-CoA = CoA + H(+) + N-decanoyl-3-oxosphinganine
RHEA:57299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + glycolate + H(+)
RHEA:56819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine ribonucleoside + H2O <=> a pyrimidine nucleobase + D-ribose
REACT:R-BTA-5685994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Long-range resection of DNA DSBs by EXO1 or DNA2 (Bos taurus)
REACT:R-DRE-372480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Danio rerio)
REACT:R-HSA-5624954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INPP5E translocates to the primary cilium (Homo sapiens)
RHEA:72040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate(in) + orotate(out) => nicotinate(out) + orotate(in)
RHEA:44234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol
REACT:R-CFA-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Canis familiaris)
REACT:R-XTR-1112604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STATs are released (Xenopus tropicalis)
REACT:R-MMU-9023627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)
REACT:R-CEL-4827382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Caenorhabditis elegans)
GO:0102106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	curcumin synthase activity
RHEA:62448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP = AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]
REACT:R-SSC-9610154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated MAP2Ks and MAPKs (Sus scrofa)
RHEA:69103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
REACT:R-DRE-3222237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMYD2 methylates TP53 (Danio rerio)
RHEA:42453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate => H2O + kynurenate
RHEA:54800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) = [nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA
REACT:R-CEL-1602446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Caenorhabditis elegans)
REACT:R-HSA-8849908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM4 binds flotillin-1 (Homo sapiens)
REACT:R-RNO-174706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Rattus norvegicus)
REACT:R-DME-3222128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOC2L binds TP53 (Drosophila melanogaster)
REACT:R-RNO-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Rattus norvegicus)
RHEA:10454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-450463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Homo sapiens)
REACT:R-DME-9661397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)
RHEA:72041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate(out) + orotate(in) => nicotinate(in) + orotate(out)
RHEA:63628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hexadecanoate + holo-[ACP] = AMP + diphosphate + hexadecanoyl-[ACP]
REACT:R-MMU-1306965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Mus musculus)
REACT:R-CFA-8847875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF1:GTP binds Golgin TRIP11 (Canis familiaris)
RHEA:57682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Gallus gallus)
RHEA:52107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)
REACT:R-CFA-351963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A18 transports Gly from extracellular region to cytosol (Canis familiaris)
REACT:R-DRE-9647632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDME (Danio rerio)
REACT:R-DRE-8864105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 binds ERBB2:EGFR heterodimers (Danio rerio)
REACT:R-HSA-201685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin is released from the destruction complex (Homo sapiens)
RHEA:61501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin + UDP-alpha-D-glucose => delphinidin 3-O-beta-D-glucoside + UDP
REACT:R-SSC-1433514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)
REACT:R-DDI-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Dictyostelium discoideum)
REACT:R-CEL-8878050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 and EP300 (Caenorhabditis elegans)
RHEA:42301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]
REACT:R-HSA-2466106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BGN binds Collagen types I, VI, (IX) (Homo sapiens)
REACT:R-BTA-983700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds the activated BCR (Bos taurus)
REACT:R-RNO-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Rattus norvegicus)
RHEA:48481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP
REACT:R-HSA-9034814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 phosphorylates PLCG1 (Homo sapiens)
RHEA:62557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + H(+) => 4-methylcatechol + CO2
EC:1.1.1.265	skos:prefLabel	"3-methylbutanal reductase"
EC:1.1.1.265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-methylbutanal reductase"
REACT:R-GGA-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Gallus gallus)
RHEA:31714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-193491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Mus musculus)
REACT:R-BTA-5686657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC1:XPF cleaves flaps generated by SSA (Bos taurus)
REACT:R-SSC-8848930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 translocates to the nucleus (Sus scrofa)
REACT:R-BTA-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Bos taurus)
REACT:R-BTA-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Bos taurus)
GO:0050160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orsellinate-depside hydrolase activity
GO:0050160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lecanorate hydrolase activity
RHEA:13111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-hydroxy-2-acetamidofluorene + NADH => 2-acetamidofluorene + H2O + NAD(+)
RHEA:39071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanedioyl-CoA + O2 = (2E)-dodecenedioyl-CoA + H2O2
REACT:R-CEL-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Caenorhabditis elegans)
RHEA:41931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octadecanoyl-[ACP]
RHEA:18541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine = dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine
RHEA:18541	skos:prefLabel	"10-hydroxydihydrosanguinarine 10-O-methyltransferase"
RHEA:18541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"10-hydroxydihydrosanguinarine 10-O-methyltransferase"
RHEA:36526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
REACT:R-CFA-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Canis familiaris)
REACT:R-DME-5654582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates SHC1 (Drosophila melanogaster)
RHEA:61051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lochnericine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]
RHEA:47556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + taurodeoxycholate = deoxycholate + taurine
RHEA:56611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydrosulfopterin + glycine + H2O <=> L-serine + tetrahydrosulfopterin
RHEA:41308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-CFA-8870678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fibrinogen products bind TLR4:LY96 (Canis familiaris)
RHEA:39730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin(in) <=> a sphingomyelin(out)
REACT:R-BTA-9614423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO1 (Bos taurus)
REACT:R-SCE-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Saccharomyces cerevisiae)
RHEA:51285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate
REACT:R-HSA-9009085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEXA:NR3C1 complex binds RUNX2 gene proximal promoter (Homo sapiens)
RHEA:69341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-prop-1-en-1-SO-peroxol => (Z)-propanethial S-oxide
REACT:R-SSC-8875482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin to ubiquitinated MET (Sus scrofa)
RHEA:63905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-phenylpyruvate + H(+) => H2O + phenguignardate
REACT:R-HSA-9037761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Homo sapiens)
REACT:R-MMU-416725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA6D binds to PLXNA1:TREM2:DAP12 (Mus musculus)
REACT:R-MMU-202144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Mus musculus)
REACT:R-SSC-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Sus scrofa)
RHEA:64527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA <=> 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]
REACT:R-RNO-996755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFPM proteins bind GATA proteins (Rattus norvegicus)
REACT:R-RNO-2730870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
REACT:R-BTA-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Bos taurus)
REACT:R-MMU-4341070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PPARA with SUMO1 (Mus musculus)
REACT:R-MMU-5635839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3:SUFU dissociates (Mus musculus)
RHEA:69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-[tubulin] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]
REACT:R-RNO-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Rattus norvegicus)
REACT:R-HSA-9616243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA (Homo sapiens)
REACT:R-XTR-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Xenopus tropicalis)
REACT:R-BTA-9632034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GlcA to chondroitin (Bos taurus)
REACT:R-RNO-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Rattus norvegicus)
RHEA:43747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cytidine(34) in tRNA(Ile2) + L-lysine <=> AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)
REACT:R-RNO-193452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Rattus norvegicus)
RHEA:46865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
REACT:R-CFA-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Canis familiaris)
REACT:R-GGA-2179415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Gallus gallus)
RHEA:46688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oyl-CoA + A = 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2
RHEA:15960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-altronate <=> 2-dehydro-3-deoxy-D-gluconate + H2O
GO:0019961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interferon binding
GO:0019961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN binding
REACT:R-GGA-1250383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Gallus gallus)
REACT:R-RNO-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Rattus norvegicus)
RHEA:29607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + nitrous oxide = H(+) + NADH + 2 nitric oxide
REACT:R-XTR-205238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 interacts with p-KIT (Xenopus tropicalis)
RHEA:49856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5688289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Sus scrofa)
GO:0050163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxaloacetate keto-enol-isomerase activity
GO:0050163	skos:prefLabel	"oxaloacetate tautomerase"
GO:0050163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate tautomerase activity
GO:0050163	skos:altLabel	"oxalacetic keto--enol isomerase"
GO:0050163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxaloacetate keto-enol tautomerase activity
GO:0050163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate = enol-oxaloacetate
GO:0050163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalacetic keto-enol isomerase activity
GO:0050163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxaloacetate tautomerase"
GO:0050163	skos:altLabel	"oxaloacetate keto--enol tautomerase"
REACT:R-GGA-433593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Gallus gallus)
REACT:R-DME-166387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The FA anion diffuses away laterally from UCP (Drosophila melanogaster)
REACT:R-HSA-6803227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of high activity BRAF complexes (Homo sapiens)
RHEA:63462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+) => (2E,6E,10E)-geranylgeraniol + GTP
RHEA:66061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxohexanoate + L-kynurenine => H2O + kynurenate + L-2-aminohexanoate
RHEA:64978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGMP + 2 H(+) + 2 phosphate => 8-oxo-dGTP + 2 H2O
RHEA:19147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + H(+) + sulfate => D-glucose 6-sulfate + H2O
RHEA:56734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	echinenone + H2O => 4,4-dihydroxy-all-trans-beta-carotene
REACT:R-HSA-9010643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP5 recruits PKC to ROBO2 (Homo sapiens)
REACT:R-RNO-2730959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN7:OSTM1 exchanges Cl- for H+ (Rattus norvegicus)
RHEA:15306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H2O + NAD(+) => glycine betaine + 2 H(+) + NADH
RHEA:43635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) <=> an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)
REACT:R-HSA-1433423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP-RO interacts with p-c-Kit complex (Homo sapiens)
REACT:R-CFA-5693578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDP1 and TDP2 process unligatable DSB ends (Canis familiaris)
REACT:R-CFA-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Canis familiaris)
RHEA:54223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-all-trans-1,2-dihydro-neurosporene <=> all-trans-neurosporene + H2O
REACT:R-HSA-3780979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 (mitochondrial) (Homo sapiens)
RHEA:24773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + NADP(+) => chlorophyllide b + H(+) + NADPH
REACT:R-HSA-157933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD2 traffics to the nucleus (Homo sapiens)
RHEA:23927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pppGp(2'-5')A <=> 2',3'-cGAMP + diphosphate
REACT:R-HSA-73722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of UBF-1:rDNA Promoter (Homo sapiens)
REACT:R-HSA-2168883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin:Hemoglobin binds CD163 (Homo sapiens)
REACT:R-HSA-451634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
RHEA:58868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plant 4alpha-monomethylsterol monooxygenase"
RHEA:58868	skos:prefLabel	"plant 4alpha-monomethylsterol monooxygenase"
RHEA:58868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-CFA-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Canis familiaris)
REACT:R-CFA-1168640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated IkB is degraded (Canis familiaris)
GO:0019784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deNEDDylase activity
GO:0019784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Homo sapiens)
GO:0019784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-specific protease activity
RHEA:56791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[corrinoid adenosyltransferase] + cob(II)alamin <=> cob(II)alamin-[corrinoid adenosyltransferase]
RHEA:42829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:72587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + ATP + CoA = (E)-sinapoyl-CoA + AMP + diphosphate
RHEA:25851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH
REACT:R-HSA-211734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of PAK-2p34 (Homo sapiens)
RHEA:32445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-8953115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds to MGA:MAX (Gallus gallus)
REACT:R-MMU-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Mus musculus)
RHEA:11039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + quaternary ammonium(out) <=> ADP + H(+) + phosphate + quaternary ammonium(in)
REACT:R-SPO-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)
REACT:R-CFA-5684865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB dimer,C translocate from multivesicle body to lamellar body (Canis familiaris)
REACT:R-RNO-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Rattus norvegicus)
REACT:R-MMU-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Mus musculus)
RHEA:43581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-arginine => AH2 + iminoarginine
REACT:R-RNO-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Rattus norvegicus)
RHEA:63347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-amino acyl-L-threonyl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate
REACT:R-CFA-9619355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the cytosol (Canis familiaris)
REACT:R-GGA-353476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of repair factors to form the preincision complex (Gallus gallus)
REACT:R-XTR-4551648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO1 (Xenopus tropicalis)
REACT:R-RNO-6797810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAPL1 (Rattus norvegicus)
RHEA:53106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 4-hydroxyestrone + S-adenosyl-L-methionine
RHEA:28191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + H(+) + H2O => 2'-deoxyinosine + NH4(+)
REACT:R-BTA-5693346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CECRI deaminates Ade-Rib to Ino (Bos taurus)
RHEA:64943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGDP + H2O <=> dGMP + H(+) + phosphate
RHEA:36324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH => (9Z)-octadecen-1-ol + CoA + 2 NADP(+)
EC:3.5.2.-	skos:prefLabel	"In cyclic amides"
EC:3.5.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In cyclic amides"
REACT:R-DRE-1475017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Danio rerio)
REACT:R-XTR-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Xenopus tropicalis)
REACT:R-XTR-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Xenopus tropicalis)
REACT:R-SSC-444498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin-releasing hormone receptor binds thyrotropin (Sus scrofa)
RHEA:40352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DRE-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Danio rerio)
REACT:R-HSA-2220957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)
GO:0047335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity
GO:0047335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphoglycerate-polyphosphate phosphotransferase activity
GO:0047335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-diphosphoglycerate-polyphosphate phosphotransferase activity
GO:0047335	skos:prefLabel	"3-phosphoglyceroyl-phosphate--polyphosphate phosphotransferase"
GO:0047335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) = (2R)-3-phosphoglycerate + [phosphate](n+1)
GO:0047335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity
GO:0047335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-phosphoglyceroyl-phosphate--polyphosphate phosphotransferase"
RHEA:20919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + sulfite <=> hydrogen sulfide + L-cysteate
REACT:R-SSC-1638845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERK phosphorylates CERA to form C1P (Sus scrofa)
RHEA:11451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pregnan-21-ol <=> H(+) + NADH + pregnan-21-al
RHEA:38616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic ADP-beta-D-ribose + H2O => ADP-D-ribose
REACT:R-XTR-8956099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Xenopus tropicalis)
REACT:R-CEL-1678742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses Heparan sulfate chain(4) (Caenorhabditis elegans)
REACT:R-DME-6794346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind NLGNs (Drosophila melanogaster)
RHEA:43389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3,4-bisphosphate + H2O => 1D-myo-inositol 3-phosphate + phosphate
REACT:R-BTA-448678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTSG cleaves CASP1(1-404) (Bos taurus)
RHEA:65274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin H + H2O + NADP(+) => chrodrimanin C + H(+) + NADPH + O2
RHEA:14193	skos:prefLabel	"3-hydroxybenzoate 2-monooxygenase"
RHEA:14193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybenzoate 2-monooxygenase"
RHEA:14193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + AH2 + O2 = 2,3-dihydroxybenzoate + A + H2O
RHEA:14193	skos:altLabel	"3-hydroxybenzoate 2-hydroxylase"
REACT:R-CFA-351876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of occludin (Canis familiaris)
RHEA:19795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein] => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine
RHEA:57227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + GTP <=> N(2)-(1-hydroxy-2-oxoethyl)-GTP
REACT:R-GGA-9714477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the mitochondrial outer membrane (Gallus gallus)
REACT:R-CEL-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-SPO-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Schizosaccharomyces pombe)
REACT:R-DRE-5663050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHI and DHICA polymerise forming eumelanin (Danio rerio)
REACT:R-CEL-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Caenorhabditis elegans)
RHEA:40563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)
GO:0042615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD154 receptor binding
GO:0042615	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CD40 receptor activity
GO:0042615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40L binding
RHEA:29682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(in) <=> formate(out)
REACT:R-CFA-8864029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Canis familiaris)
REACT:R-DRE-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Danio rerio)
RHEA:20413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronoxylan 4-O-methyltransferase"
RHEA:20413	skos:prefLabel	"glucuronoxylan 4-O-methyltransferase"
RHEA:20413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine = glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine
REACT:R-CFA-5655835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Canis familiaris)
GO:0047494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity
GO:0047494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine ethanolaminephosphotransferase activity
GO:0047494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serinephosphoethanolamine synthase activity
GO:0047494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-phosphoethanolamine synthase activity
GO:0047494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine ethanolamine phosphodiester synthase activity
GO:0047494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine-phosphinico-ethanolamine synthase activity
GO:0047494	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine ethanolamine phosphate synthetase activity
REACT:R-BTA-5682858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate H2AFX (Bos taurus)
REACT:R-MMU-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Mus musculus)
REACT:R-XTR-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Xenopus tropicalis)
RHEA:57081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione
REACT:R-CFA-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Canis familiaris)
REACT:R-RNO-69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Rattus norvegicus)
REACT:R-HSA-9021068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs bind CAVs (Homo sapiens)
RHEA:48021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + H2O => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose
REACT:R-RNO-190256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to FGF (Rattus norvegicus)
GO:0001872	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	callose binding
GO:0001872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1->3)-beta-D-glucan binding
GO:0001872	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	zymosan binding
GO:0001872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-beta-D-glucan binding
REACT:R-DDI-209840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two DITs combine to form thyroxine (Dictyostelium discoideum)
RHEA:37100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP
REACT:R-DDI-8943041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Dictyostelium discoideum)
RHEA:70778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-D-quinovose + FMNH2 + O2 <=> 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite
REACT:R-CEL-1299338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRESK (Caenorhabditis elegans)
GO:0047469	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methyl-2-enelactone isomerase activity
GO:0047469	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methyl-2-enelactone methyl-isomerase activity
GO:0047469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxymethyl-4-methylbutenolide mutase activity
GO:0047469	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methyl-3-enelactone methyl isomerase activity
GO:0047469	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity
GO:0047469	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methylmuconolactone methylisomerase activity
REACT:R-XTR-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)
RHEA:39260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z)-docosenoyl-CoA => (2E,13Z)-docosadienoyl-CoA + H2O
REACT:R-SSC-9661799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)
REACT:R-RNO-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Rattus norvegicus)
REACT:R-CEL-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Caenorhabditis elegans)
REACT:R-MMU-140599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)
REACT:R-CEL-5672980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF complex (Caenorhabditis elegans)
REACT:R-XTR-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Xenopus tropicalis)
REACT:R-SCE-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Saccharomyces cerevisiae)
REACT:R-HSA-9629195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Homo sapiens)
REACT:R-GGA-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Gallus gallus)
REACT:R-XTR-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Xenopus tropicalis)
RHEA:23766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-phospho-L-serine + phosphate => diphosphate + L-serine
REACT:R-CFA-4084982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Canis familiaris)
GO:0052694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonoyl-isoleucine-12-hydroxylase activity
RHEA:65051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetoxybenzyl alcohol + NAD(+) <=> 4-acetoxybenzaldehyde + H(+) + NADH
RHEA:47041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] => 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]
RHEA:39549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA
RHEA:37893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-demethylaclacinomycin T + methanol => aclacinomycin T + H2O
RHEA:24212	skos:prefLabel	"hydroxyethylthiazole kinase"
RHEA:24212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)
RHEA:24212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyethylthiazole kinase"
REACT:R-HSA-5368596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Homo sapiens)
REACT:R-GGA-8937113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Gallus gallus)
RHEA:30664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => hapalindole H
REACT:R-HSA-178215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7:SMURF1 complex is exported to the cytosol (Homo sapiens)
EC:3.5.4.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosine deaminase"
EC:3.5.4.4	skos:altLabel	"adenosine aminohydrolase"
EC:3.5.4.4	skos:prefLabel	"adenosine deaminase"
GO:0034658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopropylmalate transmembrane transporter activity
GO:0010210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAA-Phe conjugate hydrolase activity
REACT:R-GGA-158399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein binds SERPING1 (Gallus gallus)
RHEA:46889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2
REACT:R-HSA-1791058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Cullin-7 (Homo sapiens)
RHEA:21096	skos:prefLabel	"3-dehydroquinate dehydratase"
RHEA:21096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate = 3-dehydroshikimate + H2O
RHEA:21096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydroquinate dehydratase"
RHEA:13556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose + ATP <=> ADP + alpha-D-galactose 1-phosphate + H(+)
REACT:R-DRE-390674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB1 bind ADR,NAd (Danio rerio)
REACT:R-XTR-8985914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Xenopus tropicalis)
RHEA:51167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)
REACT:R-XTR-9026005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Xenopus tropicalis)
REACT:R-DME-6814094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds ARFIP2 (Drosophila melanogaster)
REACT:R-XTR-879942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor is activated (Xenopus tropicalis)
GO:0047413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzyloxycarbonylleucine hydrolase activity
GO:0047413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity
GO:0047413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity
GO:0047413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha)-benzyloxycarbonylleucine hydrolase activity
GO:0047413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nalpha-benzyloxycarbonylleucine hydrolase activity
GO:0047413	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV
EC:3.1.21.7	skos:prefLabel	"deoxyribonuclease V"
EC:3.1.21.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyribonuclease V"
EC:3.1.21.7	skos:altLabel	"endonuclease V"
EC:3.1.21.7	skos:altLabel	"DNase V"
EC:3.1.21.7	skos:altLabel	"Escherichia coli endodeoxyribonuclease V"
RHEA:13038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + H2O => ITP + NH4(+)
RHEA:17160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + creatine <=> ADP + H(+) + N-phosphocreatine
RHEA:49587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose 1-phosphate <=> L-erythrulose 1-phosphate
RHEA:16455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formylbenzoate + pyruvate => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O
RHEA:13406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + agmatine => CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide
REACT:R-CEL-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Caenorhabditis elegans)
REACT:R-HSA-9684229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)
REACT:R-CFA-983421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Journey of cargo through Golgi complex (Canis familiaris)
RHEA:16736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + orsellinate <=> CO2 + orcinol
RHEA:33134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate <=> 3-phenylpyruvate + tetrahydrotyrosine
REACT:R-SSC-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Sus scrofa)
REACT:R-CFA-111237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR1 homodimer (Canis familiaris)
REACT:R-DME-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Drosophila melanogaster)
RHEA:11523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol + UDP-alpha-D-glucose <=> (-)-menthyl beta-D-glucoside + H(+) + UDP
RHEA:14935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]
REACT:R-CFA-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Canis familiaris)
REACT:R-CFA-6800870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the FP subcomplex (Canis familiaris)
REACT:R-SPO-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Schizosaccharomyces pombe)
RHEA:26561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O
RHEA:58043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)
RHEA:53510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione
REACT:R-MMU-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)
RHEA:68605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfopropanediol => H(+) + hydroxyacetone + sulfite
RHEA:20060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-carbamoylsarcosine <=> CO2 + NH4(+) + sarcosine
RHEA:65537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,7-trimethylurate + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theacrine
REACT:R-HSA-5662597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1H binds cadmium (Homo sapiens)
REACT:R-MMU-170087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Mus musculus)
REACT:R-DME-112379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of elongation factors to form elongation complex (Drosophila melanogaster)
REACT:R-RNO-5218815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds NCK (Rattus norvegicus)
REACT:R-XTR-5225602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR5 binds Me2sR3-replicative histone H3 (Xenopus tropicalis)
GO:0018458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-trans-isopiperitenol:NAD+ oxidoreductase activity
GO:0018458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopiperitenol dehydrogenase activity
REACT:R-DDI-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Dictyostelium discoideum)
RHEA:68745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine
RHEA:12619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => ATP + N-acetyl-alpha-D-galactosamine
REACT:R-MMU-5591086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA5 binds activated protein C (Mus musculus)
REACT:R-BTA-983422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of COPII coated vesicle (Bos taurus)
REACT:R-CEL-209765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Caenorhabditis elegans)
RHEA:59276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine = D-glutamine
RHEA:38757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
REACT:R-HSA-193780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Homo sapiens)
RHEA:22671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + lipid A disaccharide (E. coli) + UDP
RHEA:37631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-MMU-6804527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INTL1 binds bacterial glycans (Mus musculus)
REACT:R-SSC-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Sus scrofa)
RHEA:62206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + propanal => 1-propanol + 2 Fe(III)-[cytochrome c]
REACT:R-GGA-8948027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial phospholipids (Gallus gallus)
RHEA:62172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylethanolamine phosphate + H2O = an N-acylethanolamine + phosphate
EC:3.4.21.104	skos:altLabel	"mannan-binding lectin-associated serine peptidase 2"
EC:3.4.21.104	skos:altLabel	"MASP2"
EC:3.4.21.104	skos:altLabel	"mannose-binding lectin-associated serine protease-2"
EC:3.4.21.104	skos:altLabel	"MBP-associated serine protease-2"
EC:3.4.21.104	skos:prefLabel	"mannan-binding lectin-associated serine protease-2"
EC:3.4.21.104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannan-binding lectin-associated serine protease-2"
EC:3.4.21.104	skos:altLabel	"MASP-2"
RHEA:44748	skos:prefLabel	"aminoimidazole riboside kinase"
RHEA:44748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(beta-D-ribosyl)imidazole + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)
RHEA:44748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminoimidazole riboside kinase"
REACT:R-XTR-374298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid receptors bind opioid peptides (Xenopus tropicalis)
GO:0018777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity
RHEA:13334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 2-phosphate + phosphate
RHEA:71442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa(out) + L-phenylalanine(in) <=> L-dopa(in) + L-phenylalanine(out)
RHEA:11258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosyl-limonin + 2 H(+) + UDP => H2O + limonin + UDP-alpha-D-glucose
EC:3.4.23.50	skos:altLabel	"HERV K10 endopeptidase"
EC:3.4.23.50	skos:prefLabel	"human endogenous retrovirus K endopeptidase"
EC:3.4.23.50	skos:altLabel	"human endogenous retrovirus K10 endopeptidase"
EC:3.4.23.50	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"human endogenous retrovirus K endopeptidase"
EC:3.4.23.50	skos:altLabel	"HERV K10 retropepsin"
EC:3.4.23.50	skos:altLabel	"human retrovirus K10 retropepsin"
EC:3.4.23.50	skos:altLabel	"human endogenous retrovirus K113 protease"
REACT:R-MMU-176175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Stalling of DNA replication fork and RPA binding (Mus musculus)
REACT:R-SSC-5689861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of XPA and release of CAK  (Sus scrofa)
GO:0044198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc-finger-TRAF domain binding
GO:0044198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc finger TRAF-type domain binding
GO:0044198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF-type zinc finger domain binding
GO:0044198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zf-TRAF domain binding
REACT:R-CEL-432952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP180 interacts intracellularly with plectin and integrin beta4 (Caenorhabditis elegans)
RHEA:59600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methoxytryptamine + H2O + O2 = 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)
GO:0047280	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
GO:0047280	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NMN synthetase activity
GO:0047280	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide mononucleotide synthetase activity
GO:0047280	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NMN pyrophosphorylase activity
GO:0047280	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide mononucleotide pyrophosphorylase activity
GO:0047280	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NMN diphosphorylase activity
GO:0047280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide phosphoribosyltransferase activity
RHEA:51007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + 2 Fe(III)-[cytochrome cL] <=> an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)
RHEA:59034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => (Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-HSA-158942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
REACT:R-SSC-2465890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR2 binds collagen type I, II, III, V, X fibrils (Sus scrofa)
REACT:R-SSC-76453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A6 (Sus scrofa)
RHEA:49926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + O-acyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acyl-(R)-carnitine(in)
RHEA:70200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopaminechrome => 5,6-dihydroxyindole
RHEA:72393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(in) + oxalate(out) => 2 hydrogencarbonate(out) + oxalate(in)
REACT:R-HSA-190261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3c binds to FGF (Homo sapiens)
GO:0031762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FSH receptor binding
GO:0031762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	follicle-stimulating hormone receptor binding
GO:0031762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	follicle stimulating hormone receptor binding
GO:0031762	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	follicle stimulating hormone receptor ligand
REACT:R-HSA-5687079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF2BP1 binds MAPK4 mRNA (Homo sapiens)
REACT:R-BTA-212710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)
RHEA:52531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparagine <=> 2-oxosuccinamate + L-glutamate
RHEA:15164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)
REACT:R-HSA-420586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Necl-2 trans heterodimer interaction (Homo sapiens)
REACT:R-XTR-5632649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds GAS1 and PTCH (Xenopus tropicalis)
REACT:R-GGA-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Gallus gallus)
RHEA:26283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + Co-precorrin-5B + H(+) => Co-precorrin-5A + H2O
REACT:R-HSA-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Homo sapiens)
REACT:R-SSC-5687097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3 binds ETV4 (Sus scrofa)
REACT:R-MMU-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Mus musculus)
RHEA:31381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1H-pyrrole + hydrogencarbonate => H2O + pyrrole-2-carboxylate
GO:0022834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-gated channel activity
REACT:R-RNO-5610722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI3 (Rattus norvegicus)
RHEA:22410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate
REACT:R-CEL-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Caenorhabditis elegans)
REACT:R-CFA-75886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Canis familiaris)
REACT:R-BTA-5649802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Bos taurus)
REACT:R-CEL-5675433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)
REACT:R-CFA-1358791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of USP8 by P-AKT (Canis familiaris)
RHEA:37271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-glutamine(out) = ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate
RHEA:68766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine => (R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine
RHEA:22621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-tryptophan + O2 => 3-indoleglycolaldehyde + CO2 + NH4(+)
REACT:R-BTA-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Bos taurus)
RHEA:64244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
REACT:R-BTA-9627350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) binds XIAP (Bos taurus)
REACT:R-MMU-163756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of fatty acid synthase (FAS) dimer (Mus musculus)
REACT:R-DRE-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Danio rerio)
RHEA:42570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2,3-dihydroxy-p-cumate + O2
RHEA:53487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,11,17-trione + H(+) + NADPH <=> 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)
REACT:R-PFA-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Plasmodium falciparum)
REACT:R-RNO-6791109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds PCNA (Rattus norvegicus)
RHEA:46447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-hexadecenoyl-CoA + AH2 + O2 <=> (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O
REACT:R-SCE-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Saccharomyces cerevisiae)
REACT:R-DME-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)
RHEA:33027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one
REACT:R-HSA-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Homo sapiens)
GO:0106226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]
GO:0106226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide 2-hydroxyisobutyryltransferase activity
RHEA:21477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP
REACT:R-BTA-139908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DLC2 by MAPK8 (Bos taurus)
RHEA:54600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + octanoyl-CoA = 2-hydroxyoctanoyl-CoA + CO2 + succinate
RHEA:46066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-DRE-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)
REACT:R-HSA-453111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
RHEA:39883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-alpha-D-allose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH
GO:0050504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity
GO:0050504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MPG synthase activity
GO:0050504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-3-phosphoglycerate synthase activity
REACT:R-MMU-5607058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C:PROCR binds F2R (Mus musculus)
REACT:R-CEL-6803753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAAA hydrolyses NAEs to FAs and ethanolamine (Caenorhabditis elegans)
RHEA:55905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloro-L-tryptophan + chloride + FADH2 + O2 => 6,7-dichloro-L-tryptophan + FAD + 2 H2O
REACT:R-MMU-9018859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Mus musculus)
REACT:R-PFA-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Plasmodium falciparum)
REACT:R-RNO-3769401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKK and KRM bind LRP5/6 (Rattus norvegicus)
RHEA:47724	skos:altLabel	"gamma-glu-GCG"
RHEA:47724	skos:prefLabel	"glutathione-specific gamma-glutamylcyclotransferase"
RHEA:47724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione-specific gamma-glutamylcyclotransferase"
RHEA:47724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione = 5-oxo-L-proline + L-cysteinylglycine
RHEA:19457	skos:prefLabel	"2-nitrophenol 2-monooxygenase"
RHEA:19457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-nitrophenol 2-monooxygenase"
RHEA:19457	skos:altLabel	"nitrophenol oxygenase"
RHEA:19457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrophenol + 2 H(+) + 2 NADPH + O2 = catechol + H2O + 2 NADP(+) + nitrite
REACT:R-RNO-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Rattus norvegicus)
REACT:R-MMU-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Mus musculus)
REACT:R-HSA-209772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to triiodothyronine (Homo sapiens)
RHEA:56228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:41910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-[ACP] + H2O => (3R)-hydroxyhexadecanoyl-[ACP]
REACT:R-SSC-9018868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Sus scrofa)
RHEA:64021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-seryl-[protein] => GDP + H(+) + O-phospho-L-seryl-[protein]
REACT:R-MTU-879327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylglucosamine-inositol is deacetylated by Mca (Mycobacterium tuberculosis)
REACT:R-BTA-8983384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)
REACT:R-RNO-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Rattus norvegicus)
REACT:R-SSC-2534346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAM1 Binds Hyaluronic Acid (Sus scrofa)
REACT:R-CEL-176521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Caenorhabditis elegans)
REACT:R-SCE-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Saccharomyces cerevisiae)
RHEA:54753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) => dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-RNO-9696275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds GTP (Rattus norvegicus)
REACT:R-DME-376851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Drosophila melanogaster)
REACT:R-DRE-4085028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE phosphorylates ManNAc to ManNAc-6-P (Danio rerio)
REACT:R-DME-3000103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN:AMN binds CBLIF:RCbl (Drosophila melanogaster)
REACT:R-HSA-5218804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK activation by VEGFR (Homo sapiens)
RHEA:43466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein]
RHEA:30289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol => 15-cis-phytoene + 2 a plastoquinone
REACT:R-DRE-76386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 S-demethylates 6MMP (Danio rerio)
REACT:R-DDI-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Dictyostelium discoideum)
RHEA:67852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + O2 = FMN-N(5)-peroxide
RHEA:45830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexanoyl-CoA + NAD(+)
REACT:R-RNO-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Rattus norvegicus)
REACT:R-SSC-2090085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan chain(1) (Sus scrofa)
REACT:R-RNO-159425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
REACT:R-RNO-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Rattus norvegicus)
REACT:R-SCE-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Saccharomyces cerevisiae)
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amano CE
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacylglycerol ester hydrolase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steapsin
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amano P
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	salt-resistant post-heparin lipase
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triglyceridase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPL
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tributyrinase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hepatic monoacylglycerol acyltransferase
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tween hydrolase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tweenase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacylglycerol acylhydrolase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GEH
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cacordase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyrinase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heparin releasable hepatic lipase
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacetinase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol-ester hydrolase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meito sangyo OF lipase
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tweenesterase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GA 56
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	liver lipase
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amno N-AP
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipazin
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amano AP
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tween-hydrolyzing esterase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacylglycerol lipase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amano CES
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	post-heparin plasma protamine-resistant lipase
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triolein hydrolase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triglyceride lipase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	takedo 1969-4-9
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amano B
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol ester hydrolase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hepatic lipase
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	capalase L
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	meito MY 30
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tributyrin esterase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tributyrase activity
GO:0004806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triglyceride hydrolase activity
REACT:R-DRE-8952996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 forms homodimers (Danio rerio)
REACT:R-SPO-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Schizosaccharomyces pombe)
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ox-LDL particle receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized LDL particle receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidised LDL receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidised LDL particle receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidised low-density lipoprotein receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidised low-density lipoprotein particle receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidized LDL receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidized low-density lipoprotein receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxLDL receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxLDL particle receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ox-LDL receptor activity
GO:0150025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized low-density lipoprotein particle receptor activity
RHEA:37627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-XTR-8871376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds PI3P (Xenopus tropicalis)
REACT:R-HSA-5419279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)
RHEA:11453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]
RHEA:16254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) => H(+) + NADH + phenanthrene-3,4-diol
REACT:R-GGA-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Gallus gallus)
RHEA:46169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + pentanoate => AMP + diphosphate + pentanoyl-CoA
GO:0031844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pancreatic polypeptide receptor binding
GO:0031844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 4 neuropeptide Y receptor binding
GO:0031844	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 4 neuropeptide Y receptor ligand
REACT:R-CFA-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Canis familiaris)
RHEA:56821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cyclooctat-9-en-7-ol + O2 => A + cyclooctat-9-ene-5,7-diol + H2O
RHEA:39747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol(in) = cholesterol(out)
RHEA:68516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = beta-acoradiene + diphosphate
RHEA:68400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + gamma-gurjunene
RHEA:55703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O <=> an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate
REACT:R-DRE-8871366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Danio rerio)
REACT:R-XTR-2028679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Xenopus tropicalis)
REACT:R-GGA-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Gallus gallus)
REACT:R-SSC-5689317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the pre-incision complex in GG-NER (Sus scrofa)
RHEA:21323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-sorbitol <=> AH2 + keto-L-sorbose
REACT:R-SCE-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-MMU-8849085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RHOA:GTP (Mus musculus)
RHEA:72415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Li(+)(in) + Na(+)(out) = Li(+)(out) + Na(+)(in)
RHEA:41314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate
REACT:R-RNO-109380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Rattus norvegicus)
REACT:R-MMU-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
RHEA:34052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'''-acetyl-6'''-hydroxyneomycin C + H2O => 6'''-deamino-6'''-hydroxyneomycin C + acetate
RHEA:44342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + ATP + fumarate
GO:0008467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosaminyl 3-O-sulfotransferase activity
GO:0008467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoform/isozyme 1 (3-OST-1, HS3ST1)
GO:0008467	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase
GO:0008467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
GO:0008467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin-glucosamine 3-O-sulphotransferase activity
GO:0008467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity
GO:0008467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin-glucosamine 3-O-sulfotransferase activity
GO:0008467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-OST-1 activity
GO:0008467	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity
RHEA:51483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0043786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinnamate reductase activity
RHEA:14202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lyxose => D-xylulose
RHEA:44992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 2-methylbutanoyl-CoA = CoA + O-2-methylbutanoyl-(R)-carnitine
REACT:R-CFA-4411402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NLK (Canis familiaris)
REACT:R-HSA-2046298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to a branch of keratan (Homo sapiens)
REACT:R-MMU-170131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Mus musculus)
RHEA:37055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylpyruvate 3-dimethylallyltransferase"
RHEA:37055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate = 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate
RHEA:37055	skos:altLabel	"4HPP dimethylallyltransferase"
RHEA:37055	skos:prefLabel	"4-hydroxyphenylpyruvate 3-dimethylallyltransferase"
REACT:R-MMU-201712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin:TCF associates with BCL9 and PYGO (Mus musculus)
REACT:R-XTR-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Xenopus tropicalis)
RHEA:65658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholest-1,4-dien-3-one + AH2 => A + cholest-1,4-dien-3-one + H2O
RHEA:31047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonate semialdehyde + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA
REACT:R-DRE-193816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Danio rerio)
RHEA:33634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + octanoate <=> AMP + diphosphate + octanoyl-CoA
REACT:R-HSA-9610154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated MAP2Ks and MAPKs (Homo sapiens)
RHEA:22600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate
RHEA:58408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + undecan-1-ol = H(+) + NADPH + undecanal
RHEA:64562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-one + H(+) + NADH => butan-2-ol + NAD(+)
REACT:R-GGA-8855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR:DAB1 binds SH3KBP1 (Gallus gallus)
RHEA:46678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH => (4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+)
REACT:R-XTR-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Xenopus tropicalis)
REACT:R-MMU-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Mus musculus)
REACT:R-DRE-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Danio rerio)
RHEA:59143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + N(5)-[(S)-citryl]-D-ornithine <=> AMP + diphosphate + H(+) + staphyloferrin A
REACT:R-MMU-1253343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds ERBB4s80 (Mus musculus)
REACT:R-DRE-1977959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with EGFR (Danio rerio)
GO:0086007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in cardiac muscle cell action potential
REACT:R-SSC-210430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of L-Glutamate at the synapse (Sus scrofa)
RHEA:50024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine
RHEA:23631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)
REACT:R-DRE-5654399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS2 (Danio rerio)
REACT:R-HSA-1655845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) (Homo sapiens)
REACT:R-HSA-9634669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPACT binds GCN1 (Homo sapiens)
RHEA:29872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + thiosulfate(out) => ADP + H(+) + phosphate + thiosulfate(in)
REACT:R-MTU-9637589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MmpL7 transports PDIM from the cytosol to the cell wall (Mycobacterium tuberculosis)
REACT:R-DRE-173545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Danio rerio)
RHEA:24443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphate(out) <=> ADP + H(+) + 2 phosphate(in)
REACT:R-SSC-6787540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUK phosphorylates beta-Fuc to Fuc1P (Sus scrofa)
REACT:R-HSA-168930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral dsRNA:TLR3:TRIF complex recruits RIP1 (Homo sapiens)
RHEA:43494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll b + H(+) + NADPH => 7(1)-hydroxychlorophyll a + NADP(+)
REACT:R-DME-209253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylated FU phosphorylates COS (Drosophila melanogaster)
REACT:R-HSA-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
REACT:R-SCE-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Saccharomyces cerevisiae)
REACT:R-HSA-5226904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Homo sapiens)
REACT:R-RNO-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Rattus norvegicus)
REACT:R-SSC-2314686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS2 (Sus scrofa)
RHEA:38841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine
REACT:R-CEL-77585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Caenorhabditis elegans)
REACT:R-DDI-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Dictyostelium discoideum)
REACT:R-XTR-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Xenopus tropicalis)
RHEA:54656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linalool isomerase"
RHEA:54656	skos:prefLabel	"linalool isomerase"
RHEA:54656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalool = (2E)-geraniol
RHEA:54656	skos:altLabel	"3,1-hydroxyl-Delta(1)-Delta(2)-mutase (linalool isomerase)"
RHEA:20003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + 2 H(+) + NADH => glycolaldehyde + H2O + NAD(+)
REACT:R-GGA-8987105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)
REACT:R-HSA-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Homo sapiens)
REACT:R-HSA-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Homo sapiens)
RHEA:54552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate
REACT:R-CEL-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Caenorhabditis elegans)
RHEA:57265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glycolate + H(+)
REACT:R-GGA-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Gallus gallus)
RHEA:65865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androst-1-ene-3,17-dione + A + H2O => 5alpha-androstan-1,3,17-trione + AH2
GO:0102422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity
REACT:R-MMU-9630923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
REACT:R-RNO-8982641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Rattus norvegicus)
RHEA:20988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate
RHEA:44691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)
GO:0043221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC family protein binding
GO:0043221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural maintenance of chromosomes family protein binding
REACT:R-MMU-74948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates p-RHO to RHO (Mus musculus)
REACT:R-SSC-5662662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosinase oxidises tyrosine to dopaquinone (Sus scrofa)
RHEA:12181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + S-adenosyl-L-methionine => H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine
GO:0031892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 3 PACAP receptor binding
GO:0031892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 vasoactive intestinal polypeptide receptor binding
GO:0031892	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 vasoactive intestinal polypeptide receptor ligand
REACT:R-CFA-3828025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP14 (Canis familiaris)
REACT:R-MMU-5624126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome bind ciliary cargo (Mus musculus)
REACT:R-DRE-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Danio rerio)
GO:0005338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide-sugar transmembrane transporter activity
GO:0008010	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	structural constituent of larval cuticle
GO:0008010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of chitin-based larval cuticle
REACT:R-RNO-4085021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Rattus norvegicus)
EC:7.3.2.3	skos:prefLabel	"ABC-type sulfate transporter"
EC:7.3.2.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type sulfate transporter"
EC:7.3.2.3	skos:altLabel	"sulfate-transporting ATPase"
EC:7.3.2.3	skos:altLabel	"sulfate ABC transporter"
REACT:R-CEL-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)
RHEA:58193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin => dihydrobisanhydrobacterioruberin + diphosphate
RHEA:35080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	doxorubicin(in) => doxorubicin(out)
RHEA:57476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + H2O2 = 2-hydroxydodecanoate + H2O
REACT:R-BTA-5618098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Bos taurus)
RHEA:17949	skos:prefLabel	"3-hydroxy-4-oxoquinoline 2,4-dioxygenase"
RHEA:17949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-4-oxoquinoline 2,4-dioxygenase"
RHEA:17949	skos:altLabel	"3-hydroxy-4(1H)-one, 2,4-dioxygenase"
RHEA:17949	skos:altLabel	"3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase"
RHEA:17949	skos:altLabel	"quinoline-3,4-diol 2,4-dioxygenase"
RHEA:17949	skos:altLabel	"(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase"
RHEA:17949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-1H-quinolin-4-one + O2 = CO + H(+) + N-formylanthranilate
REACT:R-SPO-9626816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds p-S345-NCF1 (Schizosaccharomyces pombe)
RHEA:52516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline + ubiquinone-10 = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10
REACT:R-RNO-8875568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 activates RAP1 (Rattus norvegicus)
REACT:R-HSA-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Homo sapiens)
RHEA:21514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-galactonate => 3,6-anhydro-L-galactonate
REACT:R-RNO-389639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Rattus norvegicus)
REACT:R-XTR-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Xenopus tropicalis)
GO:0051213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioxygenase activity
GO:0051213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative demethylation of 3-meC damaged DNA by ALKBH2 (Homo sapiens)
RHEA:20139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baccatin III + CoA => 10-deacetylbaccatin III + acetyl-CoA
REACT:R-DME-1667005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Drosophila melanogaster)
REACT:R-DDI-5653936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Ragulator complex (Dictyostelium discoideum)
REACT:R-HSA-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)
RHEA:24596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-histidine = CoA + H(+) + N(alpha)-acetyl-L-histidine
RHEA:24596	skos:prefLabel	"histidine N-acetyltransferase"
RHEA:24596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histidine N-acetyltransferase"
REACT:R-RNO-264679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serum albumin binds 2-lysophosphatidylcholine (Rattus norvegicus)
RHEA:50298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Bos taurus)
RHEA:32142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + malonate <=> AMP + diphosphate + malonyl-CoA
RHEA:43865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)
REACT:R-HSA-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Homo sapiens)
REACT:R-CFA-2161959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Canis familiaris)
REACT:R-MMU-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Mus musculus)
RHEA:24211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-mannitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH
RHEA:56908	skos:prefLabel	"thebaine synthase"
RHEA:56908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thebaine synthase"
RHEA:56908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-O-acetylsalutaridinol = acetate + H(+) + thebaine
RHEA:56908	skos:altLabel	"THS"
REACT:R-RNO-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Rattus norvegicus)
REACT:R-XTR-8848023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds STAP2 (Xenopus tropicalis)
RHEA:48482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose
REACT:R-HSA-5617661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)
EC:3.4.24.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"IgA-specific metalloendopeptidase"
EC:3.4.24.13	skos:altLabel	"IgA protease"
EC:3.4.24.13	skos:prefLabel	"IgA-specific metalloendopeptidase"
EC:3.4.24.13	skos:altLabel	"immunoglobulin A1 proteinase"
RHEA:14057	skos:altLabel	"PDAT"
RHEA:14057	skos:prefLabel	"phospholipid:diacylglycerol acyltransferase"
RHEA:14057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a glycerophospholipid = a monoacylglycerophospholipid + a triacyl-sn-glycerol
RHEA:14057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phospholipid:diacylglycerol acyltransferase"
REACT:R-DRE-1296035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Danio rerio)
RHEA:15263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Canis familiaris)
GO:0035198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miRNA binding
GO:0035198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microRNA binding
RHEA:30743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-riboside + H2O = D-ribose + H(+) + nicotinamide
REACT:R-CFA-9023840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HATs and coactivators are recruited to the CTSD gene (Canis familiaris)
REACT:R-DRE-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Danio rerio)
REACT:R-HSA-446684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)
GO:0102723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:curcumin glucosyltransferase activity
GO:0001515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	opioid peptide activity
REACT:R-DME-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Drosophila melanogaster)
EC:4.99.1.10	skos:altLabel	"Mg-dechelatase"
EC:4.99.1.10	skos:prefLabel	"magnesium dechelatase"
EC:4.99.1.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"magnesium dechelatase"
REACT:R-RNO-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Rattus norvegicus)
REACT:R-HSA-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Homo sapiens)
RHEA:22991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + CoA + NADP(+) <=> acetyl-CoA + CO2 + NADPH
REACT:R-XTR-5654701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
GO:0102069	skos:prefLabel	"zerumbone synthase"
GO:0102069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxy-alpha-humulene + NAD(+) = H(+) + NADH + zerumbone
GO:0102069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zerumbone synthase activity
GO:0102069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zerumbone synthase"
REACT:R-MMU-6807866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the ERGIC (Mus musculus)
REACT:R-RNO-429992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARN deadenylates mRNA (Rattus norvegicus)
RHEA:27529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesol + diphosphate
RHEA:71536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate(in) + phosphate(out) => D-glucose 6-phosphate(out) + phosphate(in)
REACT:R-GGA-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Gallus gallus)
REACT:R-HSA-6804242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the complex of JMY, EP300 and TTC5 (Homo sapiens)
REACT:R-DRE-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Danio rerio)
REACT:R-DRE-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Danio rerio)
RHEA:51038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + indole-3-pyruvate imine dimer => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2
REACT:R-DME-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Drosophila melanogaster)
RHEA:33166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-riboside(in) <=> beta-nicotinamide D-riboside(out)
RHEA:45821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mesaconate + succinyl-CoA => 2-methylfumaryl-CoA + succinate
REACT:R-SSC-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
REACT:R-HSA-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Homo sapiens)
GO:0030732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine methyltransferase activity
GO:0030732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl methionine:methionine methyl transferase activity
GO:0030732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine-methionine methyltransferase activity
GO:0030732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine transmethylase activity
GO:0030732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine S-methyltransferase activity
GO:0030732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:L-methionine S-methyltransferase activity
RHEA:55879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aequorin] + coelenterazine <=> apo-[aequorin]--coelenterazine
RHEA:43878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA
REACT:R-RNO-193792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Rattus norvegicus)
REACT:R-HSA-2187261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC12 (SCARA4) binds ligands (Homo sapiens)
REACT:R-BTA-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Bos taurus)
REACT:R-CFA-193684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 recruits an atypical PKC (Canis familiaris)
REACT:R-HSA-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Homo sapiens)
RHEA:65858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a steroid 1,3-dione + AH2 => A + a 1-hydroxy-3-oxo steroid
RHEA:15411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine
GO:0047316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine:phenylpyruvate aminotransferase activity
GO:0047316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine-phenylpyruvate transaminase activity
GO:0047316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine-phenylpyruvate aminotransferase activity
GO:0047316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine--phenylpyruvate aminotransferase activity
GO:0047316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine transaminase K activity
REACT:R-GGA-8878050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 and EP300 (Gallus gallus)
REACT:R-SSC-432295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI binds Fyn and Lyn (Sus scrofa)
RHEA:53968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[BtrI ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]
GO:0047264	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP mannose alpha-mannosyltransferase activity
GO:0047264	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity
GO:0047264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heteropolysaccharide alpha-mannosyltransferase activity
GO:0047264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heteroglycan alpha-mannosyltransferase activity
GO:0047264	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity
REACT:R-CFA-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Canis familiaris)
RHEA:24154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + ADP + H(+) => adenosine 5'-phosphosulfate + ATP
REACT:R-MMU-5205799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Mus musculus)
REACT:R-MMU-5621354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Mus musculus)
REACT:R-HSA-5368279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTIF3 binds 28S ribosomal subunit (Homo sapiens)
REACT:R-HSA-1169399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Homo sapiens)
RHEA:41577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-mycarose + erythronolide B => 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)
GO:0008174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA methyltransferase activity
REACT:R-DME-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Drosophila melanogaster)
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	homoserine transsuccinylase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cystathionine synthetase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cystathionine synthase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-succinyl-L-homoserine succinate-lyase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cystathionine g-synthase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cystathionine gamma synthase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-succinyl-L-homoserine (thiol)-lyase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-succinylhomoserine (thiol)-lyase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cystathionine gamma-synthase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTT gamma synthase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-succinylhomoserine synthase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	homoserine O-transsuccinylase activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity
GO:0003962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-succinylhomoserine synthetase activity
REACT:R-BTA-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Bos taurus)
RHEA:72649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+) => 1,6-dihydroxyphenazine + NADPH + O2
REACT:R-DME-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Drosophila melanogaster)
RHEA:33103	skos:prefLabel	"alpha-muurolene synthase"
RHEA:33103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-muurolene synthase"
RHEA:33103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = alpha-muurolene + diphosphate
REACT:R-RNO-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Rattus norvegicus)
REACT:R-HSA-418872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of FADK1 (Homo sapiens)
GO:0061575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin-dependent protein serine/threonine kinase activator activity
GO:0061575	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclin-dependent protein kinase 5 activator activity
RHEA:42288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]
REACT:R-CFA-8956458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNLS:FAD oxidises dh-beta-NAD to NAD+ (Canis familiaris)
REACT:R-HSA-9699578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 phosphorylates CDKN1B (Homo sapiens)
RHEA:63134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione => apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin
REACT:R-HSA-9023351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLL1 gene expression is inhibited by MECP2 (Homo sapiens)
RHEA:66758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + domoate(out) + H(+) + phosphate => ATP + domoate(in) + H2O
REACT:R-BTA-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
REACT:R-CEL-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Caenorhabditis elegans)
RHEA:45313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin H2
REACT:R-MMU-5672954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Mus musculus)
RHEA:36086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycerol + H(+) + phosphocholine
RHEA:60215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate
RHEA:20741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trans-2,3-epoxysuccinate => (2R,3S)-tartrate
RHEA:66036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate
REACT:R-HSA-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Homo sapiens)
REACT:R-CEL-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Caenorhabditis elegans)
REACT:R-DRE-352107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Danio rerio)
REACT:R-GGA-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Gallus gallus)
REACT:R-BTA-112271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex dissociates (Bos taurus)
REACT:R-CEL-198440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Caenorhabditis elegans)
REACT:R-CFA-8871194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
GO:0034806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzo(a)pyrene 11,12-dioxygenase activity
RHEA:27625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + 7 isopentenyl diphosphate <=> 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate
EC:2.7.4.22	skos:altLabel	"uridine monophosphate kinase"
EC:2.7.4.22	skos:prefLabel	"UMP kinase"
EC:2.7.4.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UMP kinase"
EC:2.7.4.22	skos:altLabel	"uridylate kinase"
EC:2.7.4.22	skos:altLabel	"UMP-kinase"
EC:2.7.4.22	skos:altLabel	"UMPK"
REACT:R-CFA-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Canis familiaris)
REACT:R-RNO-2514772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Rattus norvegicus)
RHEA:22802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	obtusifoliol => cycloeucalenol
RHEA:31578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTP + H2O <=> 8-oxo-dGMP + diphosphate + H(+)
GO:0005158	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	insulin receptor ligand
GO:0005158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insulin receptor binding
RHEA:60205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate
REACT:R-RNO-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Rattus norvegicus)
RHEA:39324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)
REACT:R-XTR-6806629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tonofilament bundles (Xenopus tropicalis)
RHEA:42887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H(+)
REACT:R-HSA-163669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of pyruvate kinase gene by ChREBP:MLX (Homo sapiens)
RHEA:63923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine
RHEA:11677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose + H2O + NADP(+) => D-ribonate + 2 H(+) + NADPH
REACT:R-HSA-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Homo sapiens)
REACT:R-HSA-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)
REACT:R-RNO-5682967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 binds DNA DSBs (Rattus norvegicus)
REACT:R-SPO-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Schizosaccharomyces pombe)
REACT:R-DME-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Drosophila melanogaster)
RHEA:40516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose 1-phosphate => (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate
REACT:R-GGA-5649711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 incises DNA strand 5' to the AP site (Gallus gallus)
RHEA:36759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-GalNAc:alpha-D-GalNAc-diphosphoundecaprenol alpha-1,3-N-acetylgalactosaminyltransferase"
RHEA:36759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:36759	skos:prefLabel	"UDP-GalNAc:alpha-D-GalNAc-diphosphoundecaprenol alpha-1,3-N-acetylgalactosaminyltransferase"
REACT:R-SSC-8875523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS3 (Sus scrofa)
REACT:R-DRE-9756162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)
RHEA:65510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NH4(+) + pre-mycofactocin => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2
RHEA:51204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH
RHEA:15559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + Ni(2+)(in) + phosphate => ATP + H2O + Ni(2+)(out)
RHEA:30375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thujopsene synthase"
RHEA:30375	skos:prefLabel	"thujopsene synthase"
RHEA:30375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate
RHEA:42826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NAD(+) + tetracenomycin C => 2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2
REACT:R-HSA-205321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of KIT and sSCF (Homo sapiens)
REACT:R-CEL-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Caenorhabditis elegans)
GO:0004603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	norepinephrine methyltransferase activity
GO:0004603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	norepinephrine N-methyltransferase activity
GO:0004603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity
GO:0004603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	noradrenalin N-methyltransferase activity
GO:0004603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylethanolamine N-methyltransferase activity
GO:0004603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	noradrenaline N-methyltransferase activity
GO:0004603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenethanolamine N-methyltransferase activity
GO:0004603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenethanolamine methyltransferase activity
REACT:R-BTA-981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3 convertases spontaneously dissociate (Bos taurus)
REACT:R-BTA-5624132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Bos taurus)
REACT:R-MMU-8853774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Mus musculus)
REACT:R-CFA-5687675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates remaining SSBs in MMEJ (Canis familiaris)
REACT:R-SPO-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Schizosaccharomyces pombe)
REACT:R-SSC-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Sus scrofa)
RHEA:63181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 O2 => H(+) + NADP(+) + 2 superoxide
RHEA:21231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltose <=> beta-maltose
RHEA:18017	skos:prefLabel	"indolepyruvate decarboxylase"
RHEA:18017	skos:altLabel	"3-(indol-3-yl)pyruvate carboxy-lyase"
RHEA:18017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indolepyruvate decarboxylase"
RHEA:18017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-pyruvate = CO2 + indole-3-acetaldehyde
RHEA:18017	skos:altLabel	"indole-3-pyruvate decarboxylase"
RHEA:18017	skos:altLabel	"indol-3-yl-pyruvate carboxy-lyase"
GO:0062148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate
GO:0062148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gamma-glutamyl-L-propargylglycine hydroxylase activity
RHEA:43543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[isocitrate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]
REACT:R-DRE-193068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates PREG (Danio rerio)
REACT:R-CFA-4093329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SDCBP (Canis familiaris)
REACT:R-XTR-388529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholecystokinin receptors bind cholecystokinin (Xenopus tropicalis)
REACT:R-SSC-5607722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK phosphorylates IKKA dimer (Sus scrofa)
GO:0018856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl acetate-CoA ligase activity
RHEA:21539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA <=> 3-methyl-(2E)-glutaconyl-CoA + H2O
REACT:R-BTA-192178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
REACT:R-PFA-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Plasmodium falciparum)
RHEA:33264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-9027302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)
REACT:R-SSC-8866405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)
RHEA:69650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + quercetin 4'-O-beta-D-glucoside <=> beta-D-glucose + quercetin
REACT:R-RNO-8953946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Rattus norvegicus)
RHEA:36100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + S-adenosyl-L-methionine => methyl benzoate + S-adenosyl-L-homocysteine
RHEA:38415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)
REACT:R-HSA-8938108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds cathepsin L (Homo sapiens)
RHEA:22565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-[ACP] + NADP(+) => a (2E)-enoyl-[ACP] + H(+) + NADPH
REACT:R-SSC-388503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxytocin receptor bind oxytocin (Sus scrofa)
REACT:R-DRE-9796379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Danio rerio)
REACT:R-DME-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Drosophila melanogaster)
REACT:R-BTA-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Bos taurus)
REACT:R-RNO-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Rattus norvegicus)
RHEA:18281	skos:prefLabel	"fumarate reductase (NADH)"
RHEA:18281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumarate reductase (NADH)"
RHEA:18281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + succinate = fumarate + H(+) + NADH
RHEA:18281	skos:altLabel	"NADH-dependent fumarate reductase"
RHEA:63800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose = GDP-beta-L-gulose
REACT:R-GGA-5218847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 binds NCK (Gallus gallus)
EC:3.4.24.71	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endothelin-converting enzyme 1"
EC:3.4.24.71	skos:altLabel	"ECE-1"
EC:3.4.24.71	skos:prefLabel	"endothelin-converting enzyme 1"
REACT:R-SSC-5649764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)
RHEA:29944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) => 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)
GO:0070984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SET domain binding
GO:0070984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SET binding
REACT:R-MMU-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Mus musculus)
REACT:R-MMU-167419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex releases GDP (Mus musculus)
REACT:R-HSA-352107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Homo sapiens)
REACT:R-DDI-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Dictyostelium discoideum)
REACT:R-BTA-4551661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates RNF168 with SUMO1 (Bos taurus)
REACT:R-DME-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Drosophila melanogaster)
REACT:R-BTA-870479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) binds to ubiquitinated SMAD4 (Bos taurus)
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indolyl-3-alkan alpha-hydroxylase activity
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TSO II
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan side-chain alpha,beta-oxidase activity
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan side chain oxidase II
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan side chain oxidase type I
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan side-chain oxidase activity
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TSO activity
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-alkane alpha-hydroxylase activity
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan 2'-dioxygenase activity
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan side chain oxidase activity
GO:0050360	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TSO I
RHEA:70774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-8854905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)
GO:0106376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA
GO:0106376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA lyase activity
REACT:R-BTA-428231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Bos taurus)
RHEA:29371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP + H2O = 2'-deoxyadenosine + phosphate
RHEA:15254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate + H(+) => CO2 + itaconate
REACT:R-GGA-6803523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Gallus gallus)
REACT:R-SPO-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Schizosaccharomyces pombe)
REACT:R-HSA-8849068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARHGAP35 (Homo sapiens)
REACT:R-DRE-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Danio rerio)
REACT:R-HSA-5621010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB1 activates HOXA2 expression (Homo sapiens)
RHEA:48794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer
RHEA:60935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-5651739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Xenopus tropicalis)
RHEA:51690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-L-tagatose + NADH => galactitol + NAD(+)
RHEA:15747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->1)-beta-D-fructosyl](n+1) + D-glucose => [(2->1)-beta-D-fructosyl](n) + sucrose
REACT:R-DRE-2022378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Danio rerio)
REACT:R-MMU-212713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLC-gamma1 dissociates from EGFR (Mus musculus)
REACT:R-MMU-444859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Mus musculus)
GO:0016422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity
GO:0016422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO:0016422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO:0016422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity
RHEA:38773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:25998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + N(1)-acetylspermine + O2
REACT:R-HSA-8952749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
RHEA:44588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol
REACT:R-DRE-9653585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Farn-Me KRAS4B binds calmodulin (Danio rerio)
REACT:R-BTA-1222685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathelicidin LL-37 binds to bacterial cell wall (Bos taurus)
REACT:R-DRE-69562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Danio rerio)
GO:0042900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinose transmembrane transporter activity
REACT:R-BTA-1067640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R-2 (Bos taurus)
GO:0008252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotidase activity
GO:0008252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyinosine-activated nucleotidase (DIAN)
GO:0008252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid nucleotidase activity
GO:0008252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NSP I
GO:0008252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleotide phosphohydrolase activity
GO:0008252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleoside-activated nucleotidase (DAN)
GO:0008252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleotide-specific phosphatase activity
GO:0008252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NSP II
REACT:R-HSA-1236935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Homo sapiens)
RHEA:57310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => CTP + H(+) + N(5)-phospho-L-glutamine
GO:0000332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomerase, template
GO:0000332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomerase RNA
GO:0000332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	template for synthesis of G-rich strand of telomere DNA activity
RHEA:46817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:23868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase"
RHEA:23868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone
RHEA:23868	skos:altLabel	"(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase"
RHEA:23868	skos:prefLabel	"(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase"
RHEA:67236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolyl-CoA + propanoyl-CoA = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA
RHEA:40624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tritetradecanoylglycerol => 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate
REACT:R-DRE-388831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CD28 (Danio rerio)
RHEA:41554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ophiobolin F => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O
RHEA:69293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => goitrin + sulfate
REACT:R-GGA-2396606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Gallus gallus)
RHEA:31946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0016663	skos:prefLabel	"With oxygen as acceptor"
GO:0016663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
GO:0016663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor
REACT:R-GGA-114697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Gallus gallus)
REACT:R-HSA-2213208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type X collagen associates with collagen type II fibrils (Homo sapiens)
REACT:R-BTA-9010815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLITs bind keratan sulfate (Bos taurus)
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-L-arabinosidase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-arabinofuranosidase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-arabinosidase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arabinosidase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polysaccharide alpha-L-arabinofuranosidase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-arabinofuranosidase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arabinosidase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-L-arabinanase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arabinofuranosidase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-L-arabinofuranoside hydrolase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-L-arabinofuranoside arabinofuranohydrolase activity
GO:0046556	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-arabinofuranosidase activity
RHEA:34386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP
RHEA:49573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + 2 H(+) => coproporphyrin III + Fe(2+)
REACT:R-HSA-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Homo sapiens)
REACT:R-RNO-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Rattus norvegicus)
REACT:R-SPO-390329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)
GO:0060072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BK calcium-activated potassium channel activity
GO:0060072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BK KCa channel activity
GO:0060072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	large conductance calcium-activated potassium channel activity
GO:0060072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	large conductance KCa channel activity
GO:0060072	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BK channel activity
REACT:R-MMU-6803719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds ZNF385A (Mus musculus)
RHEA:41745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)
GO:0016152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mercuric reductase activity
GO:0016152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced NADP:mercuric ion oxidoreductase activity
GO:0016152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Hg:NADP+ oxidoreductase activity
GO:0016152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mercuric ion reductase activity
GO:0016152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mercurate(II) reductase activity
GO:0016152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mercury (II) reductase activity
GO:0016152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mer A
GO:0016152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mercury reductase activity
GO:0016152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mercury(II) reductase activity
REACT:R-XTR-8875490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind ubiquitinated MET (Xenopus tropicalis)
RHEA:67957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-chloropropanoate + H2O => (R)-lactate + chloride + H(+)
GO:0004579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity
GO:0004579	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligomannosyltransferase activity
GO:0004579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyldiphosphooligosaccharide-protein glycosyltransferase activity
GO:0004579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity
GO:0004579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagine N-glycosyltransferase activity
GO:0004579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity
GO:0004579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity
GO:0004579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity
GO:0004579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
REACT:R-CEL-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Caenorhabditis elegans)
REACT:R-HSA-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Homo sapiens)
REACT:R-DRE-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Danio rerio)
REACT:R-GGA-936897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)
RHEA:42360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allulose = keto-D-fructose
RHEA:42360	skos:altLabel	"DPEase"
RHEA:42360	skos:prefLabel	"D-psicose 3-epimerase"
RHEA:42360	skos:altLabel	"D-allulose 3-epimerase"
RHEA:42360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-psicose 3-epimerase"
RHEA:12301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) => 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine
REACT:R-PFA-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Plasmodium falciparum)
REACT:R-MMU-5610735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB binds ITCH (Mus musculus)
RHEA:34931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathioselenol + NADPH = glutathione + hydrogenselenide + NADP(+)
RHEA:70045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone => 6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:47349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a butanoate ester + H2O => an aliphatic alcohol + butanoate + H(+)
RHEA:35516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'''-demalonylsalvianin + malonyl-CoA => CoA + salvianin
RHEA:70085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + o-quinone methide => hydroxyclavatol
REACT:R-CEL-8851877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Caenorhabditis elegans)
REACT:R-XTR-8863973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of ERC and phagosome (Xenopus tropicalis)
REACT:R-DDI-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Dictyostelium discoideum)
GO:0030378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine racemase activity
REACT:R-BTA-9667569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,2 bind AVPR antagonists (Bos taurus)
REACT:R-SSC-417898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y4 receptor can bind to UTP (Sus scrofa)
RHEA:37475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-BTA-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Bos taurus)
RHEA:60245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]
RHEA:48939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]
GO:0102654	skos:prefLabel	"palmitoyl-[glycerolipid] 3-(E)-desaturase"
GO:0102654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"palmitoyl-[glycerolipid] 3-(E)-desaturase"
GO:0102654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity
GO:0102654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-5654628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS3 (Homo sapiens)
REACT:R-HSA-8848436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CDKN1B (Homo sapiens)
REACT:R-HSA-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Homo sapiens)
GO:0001851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C3b binding
REACT:R-SSC-449073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-3 cleaves pro-interleukin-16 (Sus scrofa)
REACT:R-HSA-5617816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A  (Homo sapiens)
RHEA:48961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O
RHEA:59939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)
REACT:R-XTR-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Xenopus tropicalis)
RHEA:62315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylate + UDP-alpha-D-glucose <=> H(+) + salicylate 2-O-beta-D-glucoside + UDP
REACT:R-BTA-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Bos taurus)
RHEA:47650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + ribitol => D-ribitol 5-phosphate + H2O
REACT:R-XTR-163670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear transport of pChREBP (Thr 666) protein (Xenopus tropicalis)
REACT:R-HSA-879724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PPARA (Homo sapiens)
REACT:R-MMU-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Mus musculus)
GO:0016684	skos:prefLabel	"Acting on a peroxide as acceptor"
GO:0016684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on a peroxide as acceptor"
GO:0016684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on peroxide as acceptor
REACT:R-XTR-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Xenopus tropicalis)
REACT:R-XTR-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Xenopus tropicalis)
RHEA:71876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurocholate(out) => 2 Na(+)(in) + taurocholate(in)
RHEA:39458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)
GO:0031737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3C chemokine receptor binding
GO:0031737	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CX3C chemokine receptor ligand
GO:0031737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fractalkine receptor binding
REACT:R-XTR-2130151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of DAP12 (Xenopus tropicalis)
REACT:R-SSC-5654734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Sus scrofa)
RHEA:70089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyclavatol methyl ether => methanol + o-quinone methide
RHEA:11350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + arsenite(out) + H(+) + phosphate => arsenite(in) + ATP + H2O
REACT:R-CEL-6814153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADO oxidises 2AET to HTAU (Caenorhabditis elegans)
REACT:R-DRE-2161794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is converted to HXA3/B3 by ALOX12 (Danio rerio)
RHEA:12929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homocitrate synthase"
RHEA:12929	skos:altLabel	"acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase"
RHEA:12929	skos:prefLabel	"homocitrate synthase"
RHEA:12929	skos:altLabel	"homocitrate synthetase"
RHEA:12929	skos:altLabel	"2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)"
RHEA:12929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)
GO:0050463	skos:altLabel	"assimilatory NADPH-nitrate reductase"
GO:0050463	skos:altLabel	"NAD(P)H bispecific nitrate reductase"
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H bispecific nitrate reductase activity
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite:NAD(P)+ oxidoreductase activity
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrate reductase [NAD(P)H]"
GO:0050463	skos:altLabel	"NADPH:nitrate oxidoreductase"
GO:0050463	skos:altLabel	"NADPH-nitrate reductase"
GO:0050463	skos:altLabel	"NADPH:nitrate reductase"
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H2:nitrate oxidoreductase activity
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	assimilatory nitrate reductase activity
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:nitrate oxidoreductase activity
GO:0050463	skos:altLabel	"nitrate reductase NAD(P)H"
GO:0050463	skos:altLabel	"NAD(P)H-nitrate reductase"
GO:0050463	skos:prefLabel	"nitrate reductase [NAD(P)H]"
GO:0050463	skos:altLabel	"assimilatory nitrate reductase"
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrate reductase (NADPH)"
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nitrite = H(+) + NADPH + nitrate
GO:0050463	skos:prefLabel	"nitrate reductase (NADPH)"
GO:0050463	skos:altLabel	"nitrate reductase (NADPH2)"
GO:0050463	skos:altLabel	"nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate))"
GO:0050463	skos:altLabel	"triphosphopyridine nucleotide-nitrate reductase"
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate reductase NAD(P)H activity
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H-nitrate reductase activity
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate reductase [NAD(P)H2]
GO:0050463	skos:altLabel	"assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase"
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate reductase [NAD(P)H] activity
GO:0050463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	assimilatory NAD(P)H-nitrate reductase activity
GO:0050463	skos:altLabel	"assimilatory NAD(P)H-nitrate reductase"
REACT:R-DDI-4641350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TOP2A with SUMO2,3 (Dictyostelium discoideum)
REACT:R-DRE-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Danio rerio)
REACT:R-XTR-4641129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is ubiquitinated by SMURF2 (Xenopus tropicalis)
RHEA:12687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + mycothione + NADPH => 2 mycothiol + NADP(+)
RHEA:51731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + H2O <=> dihydroxyacetone + phosphate
REACT:R-HSA-5687675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)
RHEA:24051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sucrose <=> alpha-D-glucose 1-phosphate + D-fructose
REACT:R-RNO-4641350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TOP2A with SUMO2,3 (Rattus norvegicus)
REACT:R-RNO-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Rattus norvegicus)
REACT:R-HSA-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Homo sapiens)
RHEA:20248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin <=> 3''-O-adenylylstreptomycin + diphosphate
RHEA:61246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + indole-3-pyruvate + NH4(+) => H2O + L-tryptophan + O2
REACT:R-RNO-983145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Rattus norvegicus)
RHEA:34162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + UDP-N-acetylbacillosamine <=> CoA + H(+) + UDP-N,N'-diacetylbacillosamine
REACT:R-HSA-9756138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)
REACT:R-HSA-350901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is organified (Homo sapiens)
REACT:R-GGA-2250301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyrrole cross-links (Gallus gallus)
RHEA:21335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-glucosamine <=> CoA + H(+) + N-acetyl-D-glucosamine
REACT:R-HSA-5679031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region (Homo sapiens)
REACT:R-DRE-74730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin degradation (Danio rerio)
RHEA:21372	skos:prefLabel	"urethanase"
RHEA:21372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"urethanase"
RHEA:21372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + urethane = CO2 + ethanol + NH4(+)
RHEA:21372	skos:altLabel	"urethane hydrolase"
RHEA:14334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol => 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol
REACT:R-DRE-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Danio rerio)
RHEA:49042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-yatein + H(+) + S-adenosyl-L-homocysteine => (-)-5'-demethylyatein + S-adenosyl-L-methionine
RHEA:28685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iminosuccinate + ubiquinol-8 => L-aspartate + ubiquinone-8
REACT:R-SSC-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Sus scrofa)
REACT:R-RNO-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Rattus norvegicus)
GO:0050382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil-5-carboxylate decarboxylase activity
GO:0050382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uracil-5-carboxylate carboxy-lyase activity
GO:0050382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uracil-5-carboxylic acid decarboxylase activity
GO:0050382	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uracil-5-carboxylate carboxy-lyase (uracil-forming)
RHEA:18378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin => ADP + H(+) + streptomycin 3''-phosphate
GO:0034604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate dehydrogenase (NAD+) activity
REACT:R-DME-9611839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β3-agonists bind ADRB3 (Drosophila melanogaster)
RHEA:55741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oleuropein => D-glucose + oleuropein aglycone
REACT:R-RNO-1358792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates activated ERBB3 (Rattus norvegicus)
RHEA:37574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
GO:0102527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethylnovobiocate synthase activity
RHEA:25232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NADP(+) <=> H(+) + L-arabinose + NADPH
REACT:R-CEL-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Caenorhabditis elegans)
REACT:R-MMU-2203516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-1-Microglobulin is cleaved (Mus musculus)
REACT:R-RNO-2396399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillins bind BMPs (Rattus norvegicus)
RHEA:47475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH <=> (3E)-tetradecenoyl-CoA + NADP(+)
RHEA:55839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + UDP-alpha-D-glucuronate <=> calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP
REACT:R-HSA-428909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-protein  G13 (Homo sapiens)
REACT:R-DME-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Drosophila melanogaster)
RHEA:59268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6)-methyl-L-lysyl-[protein] = AH2 + formaldehyde + L-lysyl-[protein]
REACT:R-HSA-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Homo sapiens)
REACT:R-RNO-8987270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Rattus norvegicus)
GO:0050176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine N-acetyltransferase activity
GO:0050176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity
GO:0050176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:L-phenylalanine N-acetyltransferase activity
RHEA:25491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (1S,5S)-alpha-pinene + diphosphate
REACT:R-CFA-2396009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds c-di-GMP (Canis familiaris)
REACT:R-GGA-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Gallus gallus)
RHEA:63040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lovastatin = H(+) + lovastatin carboxylate
RHEA:45083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine <=> ADP + dapdiamide E + H(+) + phosphate
RHEA:68055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA + H2O <=> a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)
REACT:R-DRE-5682769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI2 binds ADAM22,23 (Danio rerio)
REACT:R-CEL-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)
RHEA:22781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
RHEA:52875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-CFA-8932955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-HSA-976817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of serum amyloid P decamer (Homo sapiens)
REACT:R-SCE-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-XTR-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)
RHEA:29812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + thiamine(out) => ADP + H(+) + phosphate + thiamine(in)
REACT:R-DRE-9610154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated MAP2Ks and MAPKs (Danio rerio)
REACT:R-GGA-5659781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 forms a heterodimer with BARD1 (Gallus gallus)
REACT:R-MMU-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Mus musculus)
RHEA:12318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O
REACT:R-CEL-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Caenorhabditis elegans)
GO:0045302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycocholase activity
GO:0045302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloylglycine hydrolase activity
GO:0045302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity
GO:0045302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bile salt hydrolase activity
GO:0045302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choloyltaurine hydrolase activity
REACT:R-SCE-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Saccharomyces cerevisiae)
EC:2.4.1.371	skos:prefLabel	"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase"
EC:2.4.1.371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase"
REACT:R-DME-8866283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)
REACT:R-HSA-9670156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)
REACT:R-SSC-9638090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)
RHEA:44438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + glycerol => a 1,2-diacylglycerol + a 1-acylglycerol
REACT:R-XTR-417842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 receptor can bind to LPA (Xenopus tropicalis)
REACT:R-RNO-2129362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin microfibril assembly (Rattus norvegicus)
GO:0004376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolipid mannosyl transferase activity
GO:0004376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolipid mannosyltransferase activity
REACT:R-HSA-9756183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Homo sapiens)
REACT:R-HSA-1980039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 binds DLL1 (Homo sapiens)
REACT:R-RNO-215526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F3 20-hydroxylates LTB4 (Rattus norvegicus)
REACT:R-SPO-2430535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL phosphorylates ENSA (Schizosaccharomyces pombe)
REACT:R-GGA-2997616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Gallus gallus)
REACT:R-RNO-6810474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Rattus norvegicus)
REACT:R-RNO-9757578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDN (Rattus norvegicus)
RHEA:59806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-phenylalanine => L-phenylalanine
RHEA:10812	skos:altLabel	"SGSD"
RHEA:10812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + N-succinyl-L-glutamate + NADH
RHEA:10812	skos:altLabel	"N-succinylglutamate 5-semialdehyde dehydrogenase"
RHEA:10812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinylglutamate-semialdehyde dehydrogenase"
RHEA:10812	skos:altLabel	"succinylglutamic semialdehyde dehydrogenase"
RHEA:10812	skos:prefLabel	"succinylglutamate-semialdehyde dehydrogenase"
REACT:R-BTA-8953037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F8 forms homodimers (Bos taurus)
RHEA:35408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + medicarpin => 4'-methoxyisoflavan-2',4,7-triol
REACT:R-HSA-3244643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds cyclic GMP-AMP (Homo sapiens)
REACT:R-CEL-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Caenorhabditis elegans)
REACT:R-XTR-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Xenopus tropicalis)
REACT:R-HSA-5649671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 recognizes and binds FapyA-dsDNA (Homo sapiens)
RHEA:25097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dCMP <=> ADP + dCDP
GO:0031788	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	motilin receptor ligand
GO:0031788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	motilin receptor binding
RHEA:23153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H(+) + NADH => a ubiquinol + NAD(+)
REACT:R-HSA-6797803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds SLITRK1-6 (Homo sapiens)
RHEA:34792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + O2 => formate + H(+) + hydroxymethylphosphonate
REACT:R-HSA-9680408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD4 binds fedratinib (Homo sapiens)
REACT:R-DRE-4341072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RARA with SUMO2 (Danio rerio)
REACT:R-HSA-9648888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)
REACT:R-SSC-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Sus scrofa)
REACT:R-DRE-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Danio rerio)
REACT:R-MMU-168440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Mus musculus)
REACT:R-BTA-9635743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 binds p-T,Y-MAPK (Bos taurus)
REACT:R-RNO-5692755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates MAPK6 (Rattus norvegicus)
REACT:R-GGA-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Gallus gallus)
REACT:R-MMU-9617370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-antagonists bind ADRA1A,B,D (Mus musculus)
REACT:R-MMU-8952749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Mus musculus)
REACT:R-XTR-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Xenopus tropicalis)
RHEA:61406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine => ATP + N-(D-ribulosyl)-cadaverine
GO:0106339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (cytidine 32-2'-O)-methyltransferase activity
REACT:R-SSC-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)
REACT:R-DME-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Drosophila melanogaster)
RHEA:21938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-carbamoylputrescine + phosphate => carbamoyl phosphate + putrescine
RHEA:61355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + riboflavin(in) <=> ADP + H(+) + phosphate + riboflavin(out)
REACT:R-SSC-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Sus scrofa)
RHEA:71315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-serine(out) + 2 Na(+)(out) = chloride(in) + L-serine(in) + 2 Na(+)(in)
RHEA:16023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enol-oxaloacetate => oxaloacetate
REACT:R-CFA-6783177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates GATA3,IL33 (Canis familiaris)
RHEA:24789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate
RHEA:50497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]
RHEA:59397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine => D-leucine
GO:0070492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharide binding
REACT:R-DRE-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Danio rerio)
REACT:R-CEL-193385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of choloyl-CoA to cholate and CoASH (Caenorhabditis elegans)
GO:0047927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity
GO:0047927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity
GO:0047927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin-44 dioxygenase activity
GO:0047927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gibberellin A44 oxidase activity
GO:0047927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxygenase, gibberellin A44 oxidase activity
REACT:R-GGA-8865667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPA hydrolyses sterol esters to sterols and fatty acids (Gallus gallus)
REACT:R-RNO-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Rattus norvegicus)
REACT:R-SSC-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Sus scrofa)
RHEA:55224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CFA-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Canis familiaris)
REACT:R-SPO-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Schizosaccharomyces pombe)
REACT:R-DRE-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Danio rerio)
REACT:R-HSA-9657767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of APOD regulated by NR1H2 or NR1H3 (Homo sapiens)
GO:1990165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-strand break-containing DNA binding
GO:1990165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-strand break-containing damaged DNA binding
GO:1990165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SSB-containing DNA binding
GO:0048027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA 5'-UTR binding
GO:0048027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA 5' UTR binding
REACT:R-GGA-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Gallus gallus)
REACT:R-HSA-445084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by SRC (Homo sapiens)
RHEA:14561	skos:prefLabel	"piperidine N-piperoyltransferase"
RHEA:14561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-piperoyl-CoA + piperidine = CoA + H(+) + N-[(E,E)-piperoyl]piperidine
RHEA:14561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"piperidine N-piperoyltransferase"
REACT:R-BTA-354165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
RHEA:39851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + glycerol
RHEA:22675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate <=> diphosphate + presqualene diphosphate
RHEA:17617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene C4 = glutathione + leukotriene A4
RHEA:17617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leukotriene-C4 synthase"
RHEA:17617	skos:altLabel	"LTC4 synthase"
RHEA:17617	skos:altLabel	"leukotriene A4:glutathione S-leukotrienyltransferase"
RHEA:17617	skos:altLabel	"leukotriene C4 synthetase"
RHEA:17617	skos:altLabel	"LTC4 synthetase"
RHEA:17617	skos:prefLabel	"leukotriene-C4 synthase"
REACT:R-HSA-6786012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Homo sapiens)
REACT:R-SSC-193792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Sus scrofa)
REACT:R-MMU-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Mus musculus)
REACT:R-BTA-195664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)
REACT:R-CFA-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Canis familiaris)
REACT:R-DME-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Drosophila melanogaster)
RHEA:31742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4'-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-379382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates DA to DOPAC (Sus scrofa)
REACT:R-BTA-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Bos taurus)
REACT:R-SPO-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Schizosaccharomyces pombe)
REACT:R-HSA-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Homo sapiens)
REACT:R-RNO-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Rattus norvegicus)
REACT:R-DDI-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Dictyostelium discoideum)
REACT:R-RNO-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)
REACT:R-CFA-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Canis familiaris)
REACT:R-DDI-9668395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CC2D1B (Dictyostelium discoideum)
REACT:R-SCE-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-MMU-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Mus musculus)
RHEA:22850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanedioyl-CoA + H(+) + NADH => (3S)-hydroxyoctanedioyl-CoA + NAD(+)
RHEA:10873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-L-aspartate => a carboxylate + L-aspartate
REACT:R-RNO-5693108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Rattus norvegicus)
GO:0030599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectinoesterase activity
GO:0030599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectin demethoxylase activity
GO:0030599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectin pectylhydrolase activity
GO:0030599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectin methyl esterase activity
GO:0030599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pectinesterase activity
GO:0030599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectin methoxylase activity
GO:0030599	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pectase activity
GO:0030599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pectin methylesterase activity
REACT:R-DRE-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Danio rerio)
REACT:R-SSC-9021050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 oligomer binds ESRs (Sus scrofa)
REACT:R-XTR-5686304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Xenopus tropicalis)
REACT:R-HSA-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
RHEA:43312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate
REACT:R-SCE-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Saccharomyces cerevisiae)
RHEA:51839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
REACT:R-HSA-5654165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR1 (Homo sapiens)
REACT:R-DME-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Drosophila melanogaster)
REACT:R-DRE-9679028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 binds JAK3 inhibitors (Danio rerio)
RHEA:18496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + glycine <=> CoA + H(+) + N-benzoylglycine
REACT:R-CFA-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Canis familiaris)
REACT:R-CFA-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Canis familiaris)
REACT:R-PFA-5690856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Plasmodium falciparum)
REACT:R-CFA-177933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)
REACT:R-RNO-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Rattus norvegicus)
REACT:R-DME-1296043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of HCN channels (Drosophila melanogaster)
REACT:R-SPO-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Schizosaccharomyces pombe)
REACT:R-XTR-2213201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibres (Xenopus tropicalis)
RHEA:60953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-5-hydroxyferulate + S-adenosyl-L-methionine => (E)-sinapate + H(+) + S-adenosyl-L-homocysteine
RHEA:67300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one = 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one
REACT:R-PFA-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Plasmodium falciparum)
REACT:R-MMU-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Mus musculus)
RHEA:15427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX => coproporphyrinogen III + 2 S-adenosyl-L-methionine
REACT:R-MMU-9756177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse ATVL to ATV (Mus musculus)
RHEA:44389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
RHEA:18804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(cis-prenyl)n-diphosphate + isopentenyl diphosphate <=> (cis-prenyl)(n+1)-diphosphate + diphosphate
REACT:R-CFA-549304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal clearance of organic cations (Canis familiaris)
REACT:R-SSC-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Sus scrofa)
RHEA:32827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + methionine(out) = ADP + H(+) + methionine(in) + phosphate
REACT:R-BTA-8943041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Bos taurus)
REACT:R-SSC-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Sus scrofa)
REACT:R-MMU-2161964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Mus musculus)
RHEA:68401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + gamma-gurjunene
GO:0102375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-beta-amyrin 30-oxidase activity
RHEA:17177	skos:prefLabel	"carnitine O-octanoyltransferase"
RHEA:17177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine
RHEA:17177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnitine O-octanoyltransferase"
REACT:R-DRE-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Danio rerio)
REACT:R-GGA-5649664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyG from damaged DNA (Gallus gallus)
RHEA:72273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(in) + oxalate(out) => formate(out) + oxalate(in)
RHEA:35157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one => (S)-4,5-dihydroxypentane-2,3-dione
REACT:R-GGA-888577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GABA by GAD2 (Gallus gallus)
REACT:R-XTR-6814885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBCAP complex binds 7-methylguanosine cap of snRNA (Xenopus tropicalis)
RHEA:30446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)
RHEA:71947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-aspartate(out) + 3 Na(+)(out) = N-acetyl-L-aspartate(in) + 3 Na(+)(in)
REACT:R-BTA-8987039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL20RA (Bos taurus)
RHEA:61794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-tryptophyl-5'-AMP => ATP + L-tryptophan
GO:0044736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC activity
GO:0044736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acid-sensing ion channel activity
REACT:R-BTA-419646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:Met (Bos taurus)
REACT:R-BTA-109823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Bos taurus)
REACT:R-MMU-428752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:Gq complex (Mus musculus)
REACT:R-MMU-6781814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 deubiquitinates RNF123 (Mus musculus)
REACT:R-HSA-8955748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SOCS3 gene (Homo sapiens)
REACT:R-DRE-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)
REACT:R-XTR-5694445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH1 binds TFGA and AREG precursors (Xenopus tropicalis)
RHEA:69950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0034563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity
RHEA:22902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)
GO:0102298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenocystathione synthase activity
REACT:R-HSA-2162226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Homo sapiens)
RHEA:31746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4'-hydroxyflavanone + S-adenosyl-L-methionine <=> a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-2404137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)
RHEA:63550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin-(1-7) + L-phenylalanyl-L-histidine => angiotensin-(1-9) + H2O
RHEA:37961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
RHEA:11417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-O-galloyl-beta-D-glucose => 1,6-bis-O-galloyl-beta-D-glucose + D-glucose
GO:0043910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:coenzyme F420 adenyltransferase activity
GO:0043910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:coenzyme F420 adenylyltransferase activity
GO:0043910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F390-A synthetase activity
REACT:R-CEL-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Caenorhabditis elegans)
REACT:R-HSA-977136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Amyloid precursor proteins form ordered fibrils (Homo sapiens)
REACT:R-DRE-8940998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36RN, IL1F10 bind IL1RL2 (Danio rerio)
REACT:R-RNO-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Rattus norvegicus)
REACT:R-DRE-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Danio rerio)
GO:0052906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer RNA (m(1)G(37)) methyltransferase activity
GO:0052906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (guanine(37)-N(1))-methyltransferase activity
GO:0052906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA (m(1)G(37)) methyltransferase activity
GO:0052906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA-(N(1)G37) methyltransferase activity
GO:0008514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growing HA is extruded from the cell by ABCC5 (Homo sapiens)
GO:0008514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organic anion transmembrane transporter activity
RHEA:36756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:55217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + rhizathalene A
REACT:R-HSA-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Homo sapiens)
REACT:R-HSA-6804266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TTC5 (Homo sapiens)
REACT:R-MMU-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Mus musculus)
REACT:R-CEL-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)
REACT:R-HSA-9694632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)
REACT:R-RNO-3204311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOX1 oxidises PXL to PDXate (Rattus norvegicus)
REACT:R-DDI-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Dictyostelium discoideum)
RHEA:17902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthotoxol => H(+) + S-adenosyl-L-homocysteine + xanthotoxin
GO:0052823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity
GO:0052823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate fumarylhydrolase activity
GO:0052823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-ketonona-2,4,7-trienedoic acid hydrolase activity
RHEA:44482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine
REACT:R-HSA-194025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-deoxycortisol translocates to the mitochondrion (Homo sapiens)
RHEA:27779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) => 2-all-trans-octaprenylphenol + CO2
RHEA:28504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + S-formylmycothiol => NAD(+) + S-(hydroxymethyl)mycothiol
RHEA:72798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin-bisglucuronoside(out) <=> bilirubin-bisglucuronoside(in)
RHEA:29640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaose + H2O => alpha-D-glucose + D-maltopentaose
RHEA:15852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-ascorbate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate
RHEA:30285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+) => (-)-trans-permethrin + H2O
REACT:R-SSC-5218819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
REACT:R-DRE-382061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular processing of novel PDGFs (Danio rerio)
REACT:R-CFA-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Canis familiaris)
REACT:R-XTR-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Xenopus tropicalis)
REACT:R-SCE-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Saccharomyces cerevisiae)
REACT:R-HSA-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Homo sapiens)
RHEA:45390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine => H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:32932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol => a cardiolipin + CMP + H(+)
REACT:R-SSC-6786155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLN binds ICL-DNA (Sus scrofa)
REACT:R-SPO-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Schizosaccharomyces pombe)
REACT:R-BTA-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Bos taurus)
RHEA:13486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + S-(4-bromophenyl)-L-cysteine => 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate
RHEA:17146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxy-2,3-dihydrodaidzein + NADP(+) => 2'-hydroxydaidzein + 2 H(+) + NADPH
REACT:R-SSC-426209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG activation of TRPC channels (Sus scrofa)
REACT:R-CEL-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Caenorhabditis elegans)
GO:0102096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol = alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)
GO:0102096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity
GO:0102096	skos:prefLabel	"N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase"
GO:0102096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase"
RHEA:42224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + testosterone = AH2 + androst-4-ene-3,17-dione
RHEA:10881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthosine + H2O => 7-methylxanthine + D-ribose + H(+)
RHEA:55032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-methylornithine lipid + S-adenosyl-L-methionine = an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine
RHEA:32786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine betaine(out) + H2O <=> ADP + glycine betaine(in) + H(+) + phosphate
RHEA:48387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated fatty acid + H2O2 <=> a 3-hydroxy fatty acid + H2O
RHEA:57142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine
RHEA:55321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]
REACT:R-HSA-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Homo sapiens)
RHEA:51573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0050020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arabonate dehydratase activity
GO:0050020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinonate dehydratase activity
GO:0050020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arabonate dehydrase activity
GO:0050020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)
GO:0050020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arabinonate hydro-lyase activity
REACT:R-BTA-2395314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysino-5-ketonorleucine cross-links (Bos taurus)
REACT:R-RNO-8851550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
GO:0035671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enone reductase activity
RHEA:26439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + NADP(+) => 3-oxopropanoate + H(+) + NADPH
RHEA:13051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructuronate => D-glucuronate
REACT:R-BTA-189208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Bos taurus)
REACT:R-DME-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Drosophila melanogaster)
REACT:R-RNO-1433542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV1 (Rattus norvegicus)
RHEA:25588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate + NADP(+) = (S)-oxalosuccinate + H(+) + NADPH
RHEA:50519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]
REACT:R-HSA-8987070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Homo sapiens)
REACT:R-CFA-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Canis familiaris)
REACT:R-XTR-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-CEL-199839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate RSK (Caenorhabditis elegans)
REACT:R-BTA-209772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to triiodothyronine (Bos taurus)
REACT:R-XTR-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Xenopus tropicalis)
REACT:R-CEL-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Caenorhabditis elegans)
REACT:R-RNO-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)
REACT:R-CEL-2162226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Caenorhabditis elegans)
RHEA:10282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H(+) + S-adenosyl-L-homocysteine => 1,7-dimethylxanthine + S-adenosyl-L-methionine
REACT:R-CEL-5689000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Caenorhabditis elegans)
RHEA:66754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate => (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O
RHEA:20336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[acetyl-CoA carboxylase] <=> ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]
REACT:R-MMU-9700998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 disrupts the BRCA1:BARD1 heterodimer (Mus musculus)
RHEA:10272	skos:prefLabel	"diacylglycerol kinase (ATP)"
RHEA:10272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
RHEA:10272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diacylglycerol kinase (ATP)"
RHEA:10272	skos:altLabel	"diglyceride kinase"
RHEA:10272	skos:altLabel	"DGK"
REACT:R-MMU-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Mus musculus)
REACT:R-HSA-8877813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND5A,B exchange GTP for GDP on RAB39 (Homo sapiens)
RHEA:46123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0001108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacterial-type RNA polymerase holo enzyme binding
GO:0001108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	basal bacterial-type RNA polymerase transcription machinery binding
REACT:R-XTR-2065355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)
REACT:R-CFA-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Canis familiaris)
REACT:R-RNO-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Rattus norvegicus)
REACT:R-HSA-427514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC deacetylates histone H3 (Homo sapiens)
REACT:R-BTA-5671970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CIT binds KIF14 and PRC1 (Bos taurus)
REACT:R-HSA-9706304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRAP2 (Homo sapiens)
RHEA:33880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-scyllo-inosamine + NADP(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH
REACT:R-GGA-5686704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates DCLRE1C (Gallus gallus)
REACT:R-RNO-2730882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC-theta (Rattus norvegicus)
REACT:R-GGA-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Gallus gallus)
RHEA:18530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol + NAD(+) => 3-methylbutanal + H(+) + NADH
RHEA:21358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-ribulose + NADH => L-arabinitol + NAD(+)
GO:0015048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phthalate dioxygenase reductase activity
RHEA:40777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alpha-phenylglycine + NH4(+) => 2-amino-2-phenylacetonitrile + H(+) + 2 H2O
REACT:R-CFA-1236956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfment of particulate antigen into phagocytic vesicle (Canis familiaris)
RHEA:68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoate + H(+) + NADPH = AMP + butanal + diphosphate + NADP(+)
RHEA:67611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-methyl-ATP <=> diphosphate + H(+) + N(6)-methyl-AMP
REACT:R-DRE-110251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of hypoxanthine by MPG glycosylase (Danio rerio)
REACT:R-GGA-2404200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2 binds IGF1R (Gallus gallus)
REACT:R-DME-4332236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL neddylates TGFBR2 (Drosophila melanogaster)
RHEA:67415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:16650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphoramidate + H2O => AMP + NH4(+)
REACT:R-XTR-420233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VIP receptors bind VIP (Xenopus tropicalis)
GO:1990595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mast cell secretagogue receptor activity
GO:0160050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthine binding
GO:0016785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Selenotransferases"
GO:0016785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring selenium-containing groups
GO:0016785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenotransferase activity
GO:0016785	skos:prefLabel	"Selenotransferases"
RHEA:58388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + all-trans-hexaprenyl diphosphate = 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate
RHEA:53099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine
RHEA:46294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+)
RHEA:10780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH
REACT:R-BTA-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Bos taurus)
GO:0018851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene oxide lyase activity
GO:0018851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-pinene-oxide lyase (decyclizing)
GO:0018851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene-oxide decyclase activity
REACT:R-DRE-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Danio rerio)
RHEA:30699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + beta-alanine = 3-oxopropanoate + L-glutamate
REACT:R-HSA-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Homo sapiens)
REACT:R-MMU-373748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD72 (Mus musculus)
REACT:R-HSA-9664275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers (Homo sapiens)
REACT:R-CEL-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Caenorhabditis elegans)
RHEA:41292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoylsphing-4-enine => dodecanoate + sphing-4-enine
RHEA:18166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl + H(+) + NADH + O2 => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)
RHEA:12727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-sorbose + NADH => D-iditol + NAD(+)
REACT:R-DRE-5607726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Danio rerio)
RHEA:22362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-D-proline + H2O => D-glutamate
REACT:R-XTR-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Xenopus tropicalis)
RHEA:39853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + glycerol => 2 a 1-acyl-sn-glycerol
REACT:R-XTR-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Xenopus tropicalis)
REACT:R-CFA-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
REACT:R-HSA-211206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of DFF to the nucleus (Homo sapiens)
REACT:R-HSA-373358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR6 binds CXCL16 ligand (Homo sapiens)
REACT:R-CFA-158744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Canis familiaris)
REACT:R-SSC-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Sus scrofa)
RHEA:23091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-alkylglycerone <=> 1-O-alkylglycerone 3-phosphate + ADP + H(+)
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA topoisomerase IV activity
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA topoisomerase type II activity
GO:0003918	skos:altLabel	"DNA gyrase"
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	topoisomerase
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleate topoisomerase
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	topoisomerase II
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA topoisomerase (ATP-hydrolysing)
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA topoisomerase (ATP-hydrolyzing)"
GO:0003918	skos:altLabel	"type II DNA topoisomerase"
GO:0003918	skos:prefLabel	"DNA topoisomerase (ATP-hydrolyzing)"
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA topoisomerase II
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA topoisomerase II activity
GO:0003918	skos:altLabel	"DNA topoisomerase II"
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleic topoisomerase activity
GO:0003918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II DNA topoisomerase activity
RHEA:18739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + 2 H(+) + phosphate + selenophosphate => ATP + H2O + hydrogenselenide
REACT:R-HSA-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Homo sapiens)
REACT:R-PFA-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Plasmodium falciparum)
REACT:R-XTR-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Xenopus tropicalis)
RHEA:59558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N'-diacetylchitobionate => H2O + N,N'-diacetylchitobiono-1,5-lactone
REACT:R-SSC-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Sus scrofa)
REACT:R-BTA-6813659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE, CTSG or PRTN3 binds bacteria (Bos taurus)
RHEA:60946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isorhamnetin + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine
GO:0050314	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity
GO:0050314	skos:prefLabel	"sym-norspermidine synthase"
GO:0050314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermidine + S-methyl-5'-thioadenosine
GO:0050314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sym-norspermidine synthase"
GO:0050314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sym-norspermidine synthase activity
REACT:R-CFA-2161768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXA4 is converted to EXC4 by LTC4S (Canis familiaris)
RHEA:61249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tyrosine + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)
REACT:R-HSA-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
RHEA:39208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexacosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexacosanoyl-CoA + NADP(+)
REACT:R-MMU-2024108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some HSPGs are secreted to the plasma membrane (Mus musculus)
REACT:R-BTA-1667005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Bos taurus)
REACT:R-CFA-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Canis familiaris)
GO:0070909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate: GABA antiporter activity
GO:0070909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate/gamma-aminobutyric acid antiporter activity
GO:0070909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-gamma-aminobutyric acid antiporter activity
GO:0070909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate:gamma-aminobutyric acid antiporter activity
REACT:R-DRE-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Danio rerio)
RHEA:47095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-dihydrodipicolinate + NADP(+) <=> dipicolinate + H(+) + NADPH
RHEA:48563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate <=> D-ribose 5-phosphate + N(6)-dimethylallyladenine
RHEA:43273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GD2 + H(+) + UDP
REACT:R-RNO-2022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to heparan (Rattus norvegicus)
REACT:R-HSA-6782893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) (Homo sapiens)
REACT:R-MMU-8858498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SL (surrogate light chain) binds IgH to form pre-BCR (Mus musculus)
RHEA:17555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate => ATP + guanidinoethyl methyl phosphate
REACT:R-MTU-936659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPS is dephosphorylated to APS (Mycobacterium tuberculosis)
RHEA:27503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine => 3',5'-di-O-methyltricetin + S-adenosyl-L-methionine
GO:0098614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen selenide methyltransferase activity
GO:0098614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2Se is methylated to MeSeH by H2Se methyltransferase (Homo sapiens)
REACT:R-DRE-201521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK autophosphorylation downstream of PTN and MDK (Danio rerio)
REACT:R-SSC-6805546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I binds keratin type II (Sus scrofa)
RHEA:19073	skos:altLabel	"IKK"
RHEA:19073	skos:altLabel	"IKBKA"
RHEA:19073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]
RHEA:19073	skos:altLabel	"IKBKB"
RHEA:19073	skos:altLabel	"TBK1"
RHEA:19073	skos:altLabel	"CHUK"
RHEA:19073	skos:altLabel	"TANK-binding kinase 1"
RHEA:19073	skos:altLabel	"IKK-1"
RHEA:19073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"IkappaB kinase"
RHEA:19073	skos:altLabel	"IKK-2"
RHEA:19073	skos:prefLabel	"IkappaB kinase"
RHEA:19073	skos:altLabel	"inhibitor of NFkappaB kinase"
REACT:R-DRE-5649854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to oxidatively damaged AP site (Danio rerio)
RHEA:15279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetyl-CoA + L-lysyl-[alpha-tubulin]
REACT:R-SSC-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Sus scrofa)
RHEA:56939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-androst-5-en-3-one <=> testosterone
RHEA:54762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide
REACT:R-HSA-5362525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)
RHEA:72957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + nicotinate(in) => 2 Na(+)(out) + nicotinate(out)
REACT:R-DME-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Drosophila melanogaster)
RHEA:30230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O <=> dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)
RHEA:47094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dipicolinate + H(+) + NADPH => (S)-2,3-dihydrodipicolinate + NADP(+)
GO:0103020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose kinase activity
EC:3.4.21.90	skos:altLabel	"NsP2 proteinase"
EC:3.4.21.90	skos:altLabel	"Sindbis virus protease"
EC:3.4.21.90	skos:prefLabel	"togavirin"
EC:3.4.21.90	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"togavirin"
REACT:R-BTA-159566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Bos taurus)
REACT:R-RNO-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Rattus norvegicus)
REACT:R-BTA-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Bos taurus)
RHEA:62654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 CO2 + 7 CoA + H2O + naphtopyrone YWA1 => acetyl-CoA + 6 H(+) + 6 malonyl-CoA
REACT:R-XTR-8987097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Xenopus tropicalis)
REACT:R-RNO-450257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
RHEA:48239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-acetylphloroglucinol <=> 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)
REACT:R-DRE-140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Danio rerio)
REACT:R-HSA-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Homo sapiens)
GO:0016149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation release factor activity, codon specific
REACT:R-BTA-9647746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 trimerizes (Bos taurus)
RHEA:58855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeraniol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH
GO:0035575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity (H4-K20 specific)
GO:0035575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K20me demethylase activity
GO:0035575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4-K20 demethylase activity
GO:0035575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4-methyl-lysine-20 demethylase activity
GO:0035575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity (H4K20-specific)
GO:0035575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K20 demethylase activity
GO:0035575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates histone H4K20me1 (Homo sapiens)
REACT:R-RNO-5218916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPK2/3 phosphorylates HSP27 (Rattus norvegicus)
REACT:R-HSA-9701488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates JAK3 (Homo sapiens)
RHEA:40128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Sus scrofa)
REACT:R-SSC-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Sus scrofa)
REACT:R-SSC-5683831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCDC59 binds TTF1 (Sus scrofa)
REACT:R-BTA-8862700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMKLR1 binds Resolvin E1 (Bos taurus)
REACT:R-MMU-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Mus musculus)
RHEA:12297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylipecoside + H2O => dopamine + secologanin
REACT:R-RNO-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Rattus norvegicus)
RHEA:63215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + methylglyoxal <=> 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O
RHEA:72849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate(out) + ADP(in) => adenosine 3',5'-bisphosphate(in) + ADP(out)
REACT:R-CEL-749452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)
REACT:R-GGA-2045911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)
REACT:R-DDI-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)
REACT:R-DRE-3000399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates SP100 with SUMO1 (Danio rerio)
REACT:R-HSA-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Homo sapiens)
RHEA:53827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADH
REACT:R-DME-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)
RHEA:60156	skos:prefLabel	"ABC-type D-galactose transporter"
RHEA:60156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate
RHEA:60156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type D-galactose transporter"
RHEA:60156	skos:altLabel	"D-galactose transporting ATPase"
RHEA:60156	skos:altLabel	"D-galactose ABC transporter"
RHEA:54704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-MMU-5610742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI1 (Mus musculus)
REACT:R-BTA-5689317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the pre-incision complex in GG-NER (Bos taurus)
GO:0120299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein] + NH4(+)
GO:0120299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide histaminyltransferase activity
RHEA:44599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + H2O <=> a fatty acid + H(+) + holo-[ACP]
RHEA:25912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-5-ol = 5-hydroxyquinolin-2(1H)-one + AH2
REACT:R-BTA-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Bos taurus)
RHEA:19057	skos:altLabel	"peroxidation-inhibiting protein"
RHEA:19057	skos:prefLabel	"phospholipid-hydroperoxide glutathione peroxidase"
RHEA:19057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phospholipid-hydroperoxide glutathione peroxidase"
RHEA:19057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O
RHEA:44904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate
REACT:R-SSC-3229089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Sus scrofa)
REACT:R-HSA-8847977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRK phosphorylates PTEN (Homo sapiens)
RHEA:32370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate
REACT:R-XTR-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Xenopus tropicalis)
REACT:R-HSA-8986480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Homo sapiens)
REACT:R-GGA-8876472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 binds CHOL (Gallus gallus)
REACT:R-MMU-4570489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO2 (Mus musculus)
REACT:R-SSC-937044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 (Sus scrofa)
RHEA:69944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol
RHEA:16752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphonoacetate <=> acetate + H(+) + phosphate
RHEA:21146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n) => 5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-GGA-6794347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 dimerizes (Gallus gallus)
RHEA:71185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine(in) + L-tryptophan(out) => L-kynurenine(out) + L-tryptophan(in)
REACT:R-CFA-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Canis familiaris)
GO:0031423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexon binding
GO:0043751	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PPT
GO:0043751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyphosphate:AMP phosphotransferase activity
GO:0043751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAP
REACT:R-SSC-9707516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM dissociates from MetHb (Sus scrofa)
RHEA:72920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II
REACT:R-SPO-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Schizosaccharomyces pombe)
REACT:R-MMU-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)
RHEA:51432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-aminoethylphosphonate + acetyl-CoA = [(1S)-1-acetamidoethyl]phosphonate + CoA
REACT:R-RNO-9603419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds SRC (Rattus norvegicus)
RHEA:46999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-N-methylmyosmine + H2O <=> 6-hydroxypseudooxynicotine
REACT:R-CFA-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Canis familiaris)
RHEA:38697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin(out) => a cardiolipin(in)
REACT:R-BTA-5696968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP20, USP33 deubiquitinate ADRB2 (Bos taurus)
RHEA:43395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + H2O <=> 1D-myo-inositol 1,3-bisphosphate + phosphate
REACT:R-CEL-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Caenorhabditis elegans)
RHEA:11353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP => acetyl phosphate + ADP
REACT:R-DDI-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Dictyostelium discoideum)
REACT:R-XTR-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Xenopus tropicalis)
REACT:R-DRE-6807229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)
REACT:R-XTR-5682607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Xenopus tropicalis)
RHEA:63834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	capsaicin + CoA + H(+) => (6E)-8-methylnon-6-enoyl-CoA + vanillylamine
REACT:R-SSC-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Sus scrofa)
REACT:R-HSA-5228811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKBIA variant is not phosphorylated within IkBA:NF-kappaB (Homo sapiens)
RHEA:34800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-didehydroadipoyl-CoA + acetyl-CoA => 3-oxo-5,6-didehydrosuberyl-CoA + CoA
RHEA:36107	skos:prefLabel	"gibberellin A4 carboxyl methyltransferase"
RHEA:36107	skos:altLabel	"gibberellin A4 O-methyltransferase"
RHEA:36107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gibberellin A4 carboxyl methyltransferase"
RHEA:36107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A4 + S-adenosyl-L-methionine = O-methyl gibberellin A4 + S-adenosyl-L-homocysteine
REACT:R-XTR-1296127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of voltage gated Potassium channels (Xenopus tropicalis)
REACT:R-DME-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Drosophila melanogaster)
RHEA:15364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-alpha-D-xylose <=> a dolichyl D-xylosyl phosphate + UDP
RHEA:72493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + maleate(out) => citrate(out) + maleate(in)
REACT:R-MMU-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Mus musculus)
RHEA:31238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate <=> (4R)-4-hydroxy-2-oxoglutarate + L-glutamate
RHEA:70370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + octanoyl-CoA <=> CoA + H(+) + N-octanoyl-3-oxosphinganine
REACT:R-HSA-5654594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
GO:0080013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-geranyllinalool synthase activity
GO:0030059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aralkylamine:(azurin) oxidoreductase (deaminating) activity
GO:0030059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aralkylamine dehydrogenase (azurin) activity
GO:0030059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic amine dehydrogenase (azurin) activity
REACT:R-RNO-8964619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds ARHGEF6 (Rattus norvegicus)
REACT:R-XTR-4827383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)
GO:0034561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity
RHEA:22609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + succinate
RHEA:34862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocyclopentanecarbonitrile + 2 H2O <=> 3-oxocyclopentanecarboxylate + NH4(+)
RHEA:30418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 NADPH + O2 + octadecanal <=> formate + H2O + heptadecane + 2 NADP(+)
RHEA:13244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-fucose <=> ADP + beta-L-fucose 1-phosphate + H(+)
RHEA:33846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoylsphinganine <=> sphinganine + tetracosanoate
RHEA:42083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + H2O + NAD(+) <=> all-trans-retinoate + 2 H(+) + NADH
RHEA:24571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-phospho-beta-D-galactoside + H2O <=> an alcohol + D-galactose 6-phosphate
REACT:R-RNO-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
RHEA:21534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + trypanothione => ATP + glutathione + glutathionylspermidine
GO:0008649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA methyltransferase activity
REACT:R-HSA-173754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Properdin stabilizes C3b:Bb bound to cell surfaces (Homo sapiens)
REACT:R-BTA-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Bos taurus)
GO:0016781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphotransferase activity, paired acceptors
REACT:R-MMU-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Mus musculus)
RHEA:53759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholoyl-CoA + cholate <=> allodeoxycholate + choloyl-CoA
REACT:R-MMU-139906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of BAD by calcineurin (Mus musculus)
RHEA:10189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + acetyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
REACT:R-RNO-5578742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO1,2:small RNA complexes interact with chromatin (Rattus norvegicus)
RHEA:29505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + patchoulol => (2E,6E)-farnesyl diphosphate + H2O
RHEA:64692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutanol + NAD(+) = 2-methylpropanal + H(+) + NADH
RHEA:60378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(in) => D-glucose(out)
REACT:R-HSA-9700658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceritinib-resistant ALK mutants don't bind ceritinib (Homo sapiens)
RHEA:60963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP
GO:0102176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloeucalenone reductase activity
REACT:R-HSA-114600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)
RHEA:41933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoyl-[ACP] => H(+) + hexadecanoate + holo-[ACP]
REACT:R-GGA-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Gallus gallus)
REACT:R-HSA-6784434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An unknown carrier transports cytosolic glyoxylate to the peroxisome (Homo sapiens)
REACT:R-MMU-2327738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Mus musculus)
REACT:R-MMU-4754176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR3-histone H3 (Mus musculus)
RHEA:34945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arbutin 6-phosphate(in) + pyruvate(in) => hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in)
RHEA:19316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)
RHEA:35839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA
RHEA:27972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + D-maltose => D-maltotriose + H2O
RHEA:24831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide
RHEA:10056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4(+)
RHEA:10056	skos:prefLabel	"3-aminobutyryl-CoA ammonia-lyase"
RHEA:10056	skos:altLabel	"L-3-aminobutyryl-CoA deaminase"
RHEA:10056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-aminobutyryl-CoA ammonia-lyase"
RHEA:30773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose + guanine => guanosine + H2O
RHEA:51008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome cL] + methanol = 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)
REACT:R-BTA-2066780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Bos taurus)
REACT:R-CFA-921155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from the receptor complex (Canis familiaris)
RHEA:45838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O
GO:0019870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium channel inhibitor activity
REACT:R-CFA-6809320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Canis familiaris)
REACT:R-GGA-1650808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Gallus gallus)
RHEA:41316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
REACT:R-BTA-9734070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET recombinant therapeutic antibodies bind MET (Bos taurus)
RHEA:54895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
RHEA:69319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> allyl thiocyanate + sulfate
RHEA:31928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Xenopus tropicalis)
RHEA:14033	skos:altLabel	"1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase"
RHEA:14033	skos:altLabel	"inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase"
RHEA:14033	skos:altLabel	"D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase"
RHEA:14033	skos:prefLabel	"glycerophosphoinositol inositolphosphodiesterase"
RHEA:14033	skos:altLabel	"D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase"
RHEA:14033	skos:altLabel	"D-inositol 1,2-cyclic phosphate 2-phosphohydrolase"
RHEA:14033	skos:altLabel	"1,2-cyclic-inositol-phosphate phosphodiesterase"
RHEA:14033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-1D-myo-inositol = 1D-myo-inositol 1-phosphate + glycerol + H(+)
RHEA:14033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerophosphoinositol inositolphosphodiesterase"
REACT:R-SSC-114542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1,RAC2,RHOG activate PI3K (Sus scrofa)
GO:0036357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phosphoglycerate kinase activity
GO:0036357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2PGK activity
RHEA:23780	skos:altLabel	"MCS"
RHEA:23780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methylcitrate synthase"
RHEA:23780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate + propanoyl-CoA = (2S,3S)-2-methylcitrate + CoA + H(+)
RHEA:23780	skos:prefLabel	"2-methylcitrate synthase"
RHEA:23780	skos:altLabel	"methylcitrate synthase"
RHEA:23780	skos:altLabel	"2-methylcitrate oxaloacetate-lyase"
RHEA:23780	skos:altLabel	"methylcitrate synthetase"
REACT:R-DME-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Drosophila melanogaster)
REACT:R-DME-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Drosophila melanogaster)
RHEA:67780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
RHEA:17926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-arabinopyanose + NAD(+) => H(+) + L-arabinono-1,4-lactone + NADH
RHEA:51210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH => 20-hydroxy-leukotriene B4 + NADP(+)
REACT:R-CFA-2731078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 2, (4) bind TGFB1 (Canis familiaris)
REACT:R-MMU-870449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 monoubiquitinates SMAD4 (Mus musculus)
RHEA:11409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + riboflavin => lumichrome + ribitol
REACT:R-RNO-5212679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3A binds Me2sR4-HIST1H4 (Rattus norvegicus)
REACT:R-MMU-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Mus musculus)
RHEA:54780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
RHEA:30214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + nitrous oxide <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide
REACT:R-XTR-177935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)
REACT:R-BTA-71588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Bos taurus)
REACT:R-HSA-5638209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC2A9 does not transport Fru, Glc, urate (Homo sapiens)
RHEA:21616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)
RHEA:50514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] => acetyl-CoA + N-terminal L-cysteinyl-[protein]
REACT:R-DDI-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Dictyostelium discoideum)
REACT:R-BTA-8878056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds EP300 (Bos taurus)
REACT:R-DME-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Drosophila melanogaster)
REACT:R-HSA-8851494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase7 hydrolyzes nucleoside triphosphates (Homo sapiens)
GO:0047594	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyhyoscyamine dioxygenase activity
GO:0047594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-beta-hydroxyhyoscyamine epoxidase activity
GO:0047594	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6beta-hydroxyhyoscyamine epoxidase activity
GO:0047594	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)
REACT:R-DRE-6800198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Danio rerio)
REACT:R-DME-110351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of SMUG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)
REACT:R-CFA-1482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by HADH (IM) (Canis familiaris)
RHEA:62842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-DME-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Drosophila melanogaster)
REACT:R-HSA-3786258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the CDKN1A promoter (Homo sapiens)
REACT:R-RNO-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Rattus norvegicus)
REACT:R-MMU-879221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSTPIP1 binds Pyrin (Mus musculus)
REACT:R-CFA-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Canis familiaris)
REACT:R-SSC-163120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Telomerase RNP and the Chromosome End (Sus scrofa)
REACT:R-RNO-2029270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLCgamma to membrane (Rattus norvegicus)
REACT:R-SCE-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Saccharomyces cerevisiae)
REACT:R-HSA-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)
RHEA:58490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + succinate semialdehyde + trimethylamine => 4-(trimethylamino)butanoate + H(+) + NADH + O2
REACT:R-DME-870477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Drosophila melanogaster)
REACT:R-SSC-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Sus scrofa)
REACT:R-RNO-8931648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Rattus norvegicus)
RHEA:16035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A19 + H2O + succinate => 2-oxoglutarate + gibberellin A44 + O2
REACT:R-BTA-8937419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBR3 reduces DOX to DOXOL (Bos taurus)
RHEA:65426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(out) + NAD(+)(in) => AMP(in) + NAD(+)(out)
REACT:R-GGA-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Gallus gallus)
REACT:R-DRE-265010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Danio rerio)
RHEA:34808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5625774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Danio rerio)
REACT:R-XTR-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Xenopus tropicalis)
RHEA:30550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O
REACT:R-MMU-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Mus musculus)
REACT:R-SSC-5334854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAR:RXR binds SUMO-CRABP2:atRA (Sus scrofa)
GO:0033428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAG codon-amino acid adaptor activity
GO:0033428	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine tRNA
RHEA:56422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein] => apo-[D-alanyl-carrier protein] + CoA
REACT:R-MMU-9714959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to TNF(1-233) trimer (Mus musculus)
RHEA:66327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide(out) <=> iodide(in)
RHEA:18268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) <=> 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH
REACT:R-CFA-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Canis familiaris)
REACT:R-GGA-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Gallus gallus)
RHEA:62542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroouabain + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain
RHEA:68476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroperoxy fatty acid + H(+) = a fatty aldehyde + CO2 + H2O
RHEA:65013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-AMP + holo-[ACP] => AMP + decanoyl-[ACP] + H(+)
REACT:R-GGA-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Gallus gallus)
GO:0047219	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity
GO:0047219	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity
GO:0047219	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:monoterpenol glucosyltransferase activity
GO:0047219	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-monoterpenol glucosyltransferase activity
GO:0047219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoterpenol beta-glucosyltransferase activity
REACT:R-BTA-937311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)
REACT:R-XTR-5668545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK autophosphorylates on T559 (Xenopus tropicalis)
REACT:R-BTA-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Bos taurus)
REACT:R-XTR-196417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of desmosterol to cholesterol (Xenopus tropicalis)
REACT:R-XTR-193961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Xenopus tropicalis)
RHEA:53393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] => (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Xenopus tropicalis)
REACT:R-HSA-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Homo sapiens)
REACT:R-RNO-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Rattus norvegicus)
REACT:R-HSA-420977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca permeable AMPA receptor ligand binding (Homo sapiens)
REACT:R-HSA-8948709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)
REACT:R-SSC-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Sus scrofa)
REACT:R-HSA-9617683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300,CREBBP bind SOH-C481-FOXO4 (Homo sapiens)
RHEA:46421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:40494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)
REACT:R-SSC-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Sus scrofa)
RHEA:56077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-CFA-9734475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds fibrates (Canis familiaris)
GO:1990448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EJC binding
GO:1990448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exon-exon junction complex binding
REACT:R-CEL-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Caenorhabditis elegans)
GO:0034185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein binding
REACT:R-CFA-5603467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C is released from PROCR (Canis familiaris)
REACT:R-DME-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Drosophila melanogaster)
RHEA:58731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine in rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine
REACT:R-XTR-9657619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)
REACT:R-CFA-71825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Canis familiaris)
RHEA:45614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine => H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-9009208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERKs phosphorylate RUNX2 (Homo sapiens)
REACT:R-RNO-8869425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA1A hydrolyses PS to 2-acyl LPS (Rattus norvegicus)
RHEA:23854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis,cis-muconate + 2 H(+) => catechol + O2
RHEA:22817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xylose => alpha-D-xylulofuranose
RHEA:52265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(aminomethyl)indole + 2 S-adenosyl-L-methionine => gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-MMU-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Mus musculus)
RHEA:68251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine(in) + Na(+)(in) <=> L-tyrosine(out) + Na(+)(out)
REACT:R-BTA-1971491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Bos taurus)
REACT:R-GGA-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Gallus gallus)
RHEA:51470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + pyruvate => (R)-lactate + a quinone
RHEA:63317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => 9-hydroperoxy-(10E,12Z)-octadecadienoate
GO:0102541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose 6-phosphate 1-epimerase activity
REACT:R-CFA-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Canis familiaris)
RHEA:32288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate => (2S)-2-isopropylmalate
RHEA:71058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(out) + L-methionine(in) <=> L-cysteine(in) + L-methionine(out)
RHEA:11867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine <=> dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]
REACT:R-CFA-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Canis familiaris)
REACT:R-RNO-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)
GO:0140417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-sensitive calcium-release channel activity
REACT:R-RNO-192056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Rattus norvegicus)
RHEA:10277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
RHEA:10370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose
REACT:R-HSA-5632649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds GAS1 and PTCH (Homo sapiens)
REACT:R-RNO-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Rattus norvegicus)
REACT:R-HSA-9758486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates 9b (Homo sapiens)
REACT:R-HSA-1483063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG and CDP-DAG are converted to CL by CRLS1 (Homo sapiens)
RHEA:53248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:30998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B
RHEA:15264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0030740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 3-methyltransferase activity
GO:0030740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol 1-methyltransferase activity
GO:0030740	skos:altLabel	"S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase"
GO:0030740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + S-adenosyl-L-methionine = 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine
GO:0030740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol 3-methyltransferase"
GO:0030740	skos:altLabel	"inositol L-1-methyltransferase"
GO:0030740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol 1-O-methyltransferase activity
GO:0030740	skos:altLabel	"myo-inositol 1-methyltransferase"
GO:0030740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity
GO:0030740	skos:altLabel	"myo-inositol 1-O-methyltransferase"
GO:0030740	skos:prefLabel	"inositol 3-methyltransferase"
GO:0030740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol L-1-methyltransferase activity
GO:0030740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity
GO:0030740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)
GO:0030740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine:myo-inositol 1-methyltransferase activity
REACT:R-MMU-432712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Mus musculus)
GO:0034328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyltransferase activity
REACT:R-SCE-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Saccharomyces cerevisiae)
RHEA:67396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-2545196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 dimerizes (Canis familiaris)
RHEA:17476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O <=> 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)
RHEA:58997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-carbaldehyde + O2 => H(+) + H2O2 + indole-3-carboxylate
REACT:R-CFA-450490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B/Akt phosphorylates BRF1 (Canis familiaris)
REACT:R-MMU-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase activity, class I
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type III phosphoinositide 3-kinase activity
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol-3-kinase activity
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type I phosphatidylinositol kinase activity
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase activity, class III
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PI3-kinase activity
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol 3-kinase activity
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Vps34p
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PtdIns-3-kinase activity
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase, class I, catalyst activity
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase activity, class II
GO:0016303	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity
REACT:R-SSC-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Sus scrofa)
RHEA:62475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine
REACT:R-MMU-5690250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Mus musculus)
REACT:R-SSC-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Sus scrofa)
REACT:R-HSA-193713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Homo sapiens)
REACT:R-CFA-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Canis familiaris)
RHEA:40696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol => 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:48287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside NOR1 (d18:1(4E)) + H(+) + UDP
REACT:R-HSA-5662649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT4 binds cadmium (Homo sapiens)
RHEA:44959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA + H(+) + NADPH <=> hexanoyl-CoA + NADP(+)
RHEA:13938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulfobenzoate + NADH + O2 => 3,4-dihydroxybenzoate + NAD(+) + sulfite
RHEA:35800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + H(+)
RHEA:26281	skos:prefLabel	"cobalt-precorrin 5A hydrolase"
RHEA:26281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobalt-precorrin 5A hydrolase"
RHEA:26281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-5A + H2O = acetaldehyde + Co-precorrin-5B + H(+)
REACT:R-RNO-9648983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Rattus norvegicus)
RHEA:46017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20R)-20-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone
RHEA:46648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxy-3-oxochol-4-en-22-oyl-CoA = androst-4-ene-3,17-dione + propanoyl-CoA
RHEA:71710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-phenylalanyl-L-phenylalanine(out) <=> H(+)(in) + L-phenylalanyl-L-phenylalanine(in)
REACT:R-CFA-5638009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Canis familiaris)
REACT:R-GGA-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Gallus gallus)
REACT:R-MMU-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Mus musculus)
RHEA:65625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine
REACT:R-CFA-193727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
REACT:R-SCE-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Saccharomyces cerevisiae)
REACT:R-DRE-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Danio rerio)
RHEA:43633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) => an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)
RHEA:23510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R)-7-aminocephalosporanate + glutarate => (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O
GO:0008196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitellogenin receptor activity
RHEA:67084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + hexacosanoate(in) = ADP + H(+) + hexacosanoate(out) + phosphate
REACT:R-BTA-5682607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Bos taurus)
REACT:R-DME-5690870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Drosophila melanogaster)
RHEA:19146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-sulfate + H2O => D-glucose + H(+) + sulfate
RHEA:23839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methionine + pyruvate <=> 4-methylsulfanyl-2-oxobutanoate + L-alanine
REACT:R-RNO-141186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)
RHEA:50529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]
GO:0050587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chloride:oxygen oxidoreductase activity
GO:0050587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorite dismutase activity
GO:0050587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorite O2-lyase activity
RHEA:14784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + heptanedioate <=> 6-carboxyhexanoyl-CoA + AMP + diphosphate
RHEA:14509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate
RHEA:14509	skos:altLabel	"IDS2"
RHEA:14509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mugineic-acid 3-dioxygenase"
RHEA:14509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + mugineate + O2 = 3-epihydroxymugineate + CO2 + H(+) + succinate
RHEA:14509	skos:prefLabel	"mugineic-acid 3-dioxygenase"
REACT:R-SSC-5653770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)
GO:0102725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methyldesmosterol reductase activity
GO:0102988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,12-cis-hexadecadienoic acid delta 15 desaturase activity
REACT:R-BTA-2730870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
RHEA:49093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphate
REACT:R-SSC-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Sus scrofa)
RHEA:29842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NADP(+) <=> 2-dehydro-L-idonate + H(+) + NADPH
RHEA:59198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP
RHEA:41570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin S + dTDP + H(+) => aclacinomycin T + dTDP-2-deoxy-beta-L-fucose
REACT:R-SSC-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Sus scrofa)
REACT:R-CFA-193646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF binding to p75NTR inactivates RHOA (Canis familiaris)
RHEA:23003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + NAD(+) <=> (R)-4-dehydropantoate + H(+) + NADH
REACT:R-DRE-5362459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Danio rerio)
REACT:R-SSC-450333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Sus scrofa)
RHEA:53888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + TDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + TDP
RHEA:60416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diglucosyl-enterobactin + H2O = H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2
REACT:R-HSA-453200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Homo sapiens)
REACT:R-DME-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Drosophila melanogaster)
GO:0140844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone H2B-E2 glutamate ADP-ribosyltransferase activity
GO:0140844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity
GO:0140844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E2 specific)
RHEA:17433	skos:prefLabel	"choline dehydrogenase"
RHEA:17433	skos:altLabel	"choline oxidase"
RHEA:17433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choline dehydrogenase"
RHEA:17433	skos:altLabel	"choline-cytochrome c reductase"
RHEA:17433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + choline = AH2 + betaine aldehyde
REACT:R-HSA-264865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin A (Homo sapiens)
RHEA:39608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)
EC:3.10.1.-	skos:prefLabel	"Acting on sulfur-nitrogen bonds"
EC:3.10.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on sulfur-nitrogen bonds"
REACT:R-BTA-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Bos taurus)
REACT:R-CEL-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Caenorhabditis elegans)
REACT:R-SSC-265153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Sus scrofa)
REACT:R-XTR-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Xenopus tropicalis)
RHEA:18409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH
REACT:R-CFA-8984014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Canis familiaris)
REACT:R-DRE-8939801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades PolyUb-RUNX2 (Danio rerio)
RHEA:45483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-hexachlorocyclohexane <=> (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)
REACT:R-DRE-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Danio rerio)
REACT:R-MMU-2404135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4 binds atROL (Mus musculus)
REACT:R-BTA-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Bos taurus)
RHEA:50183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate
RHEA:13310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + vanillin => 2 H(+) + NADH + vanillate
REACT:R-DDI-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)
RHEA:25995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-epi-isozizaene + diphosphate
REACT:R-SSC-5654622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)
RHEA:68830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	camphor + H(+) + NADH => borneol + NAD(+)
RHEA:51403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + serotonin <=> CoA + H(+) + N-octadecanoyl-serotonin
RHEA:28256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hex-3-en-1-yl acetate + CoA => (3Z)-hex-3-en-1-ol + acetyl-CoA
RHEA:16892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 6-acetamido-3-aminohexanoate <=> 6-acetamido-3-oxohexanoate + L-glutamate
RHEA:14444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + gentamicin C <=> CoA + H(+) + N(3)-acetylgentamycin C
GO:0106325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0051064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTP reductase activity
GO:0051064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TTP reduction
REACT:R-RNO-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Rattus norvegicus)
REACT:R-XTR-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Xenopus tropicalis)
RHEA:46424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:63926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(4)-acetylcytidine 5'-phosphate => ATP + N(4)-acetylcytidine
RHEA:52978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]
REACT:R-CFA-209087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)
RHEA:44510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:20857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + H2O => a fatty acid + sphing-4-enine
REACT:R-CEL-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Caenorhabditis elegans)
RHEA:14351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose
RHEA:16954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(2)-succinyl-L-ornithine => L-glutamate + N-succinyl-L-glutamate 5-semialdehyde
RHEA:10374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + CO2 + NADH => CoA + NAD(+) + phenylglyoxylate
RHEA:10216	skos:altLabel	"CTD kinase"
RHEA:10216	skos:prefLabel	"[RNA-polymerase]-subunit kinase"
RHEA:10216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[RNA-polymerase]-subunit kinase"
RHEA:10216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]
RHEA:41494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine
REACT:R-CFA-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Canis familiaris)
RHEA:31131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide
REACT:R-MMU-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Mus musculus)
REACT:R-HSA-6802941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
REACT:R-SSC-419841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Light stimulates opsin receptors (Sus scrofa)
RHEA:37277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + L-glutamine => H2O + L-alanyl-L-glutamine
RHEA:20167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + H(+) + N(5)-acyl-L-ornithine => H2O + N(5)-acyl-L-ornithine ester
EC:3.4.22.59	skos:prefLabel	"caspase-6"
EC:3.4.22.59	skos:altLabel	"CASP-6"
EC:3.4.22.59	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-6"
EC:3.4.22.59	skos:altLabel	"apoptotic protease Mch-2"
EC:3.4.22.59	skos:altLabel	"Mch2"
REACT:R-HSA-5633295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the NDRG1 gene promoter (Homo sapiens)
REACT:R-XTR-170810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Xenopus tropicalis)
RHEA:22607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose <=> D-fructose
REACT:R-DME-561253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A12 exchanges extracellular urate for cytosolic LACT (Drosophila melanogaster)
RHEA:40075	skos:prefLabel	"aminodeoxyfutalosine deaminase"
RHEA:40075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminodeoxyfutalosine deaminase"
RHEA:40075	skos:altLabel	"AFL deaminase"
RHEA:40075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-6-deoxyfutalosine + H(+) + H2O = futalosine + NH4(+)
RHEA:40075	skos:altLabel	"aminofutalosine deaminase"
RHEA:72485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + citrate(in) => (S)-malate(in) + citrate(out)
RHEA:33195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:60749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin II
RHEA:59062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rh2 + D-glucose => (20S)-ginsenoside Rg3 + H2O
RHEA:16335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + holo-[citrate lyase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP]
RHEA:45441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate
RHEA:24985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]
EC:3.1.21.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"T4 deoxyribonuclease IV"
EC:3.1.21.9	skos:prefLabel	"T4 deoxyribonuclease IV"
EC:3.1.21.9	skos:altLabel	"T4 endonuclease IV"
RHEA:50015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tert-butanol <=> 2-methylpropane-1,2-diol + H2O + NADP(+)
REACT:R-DDI-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Dictyostelium discoideum)
REACT:R-BTA-5618073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Bos taurus)
RHEA:32239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-carotene = all-trans-beta-carotene
RHEA:10154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + carbamoyl phosphate + H(+) + H2O => ATP + hydrogencarbonate + NH4(+)
REACT:R-DRE-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Danio rerio)
REACT:R-GGA-5610763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Gallus gallus)
REACT:R-MMU-158278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Mus musculus)
RHEA:17503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-epivellosimine + CO2 + methanol => H2O + polyneuridine aldehyde
REACT:R-CFA-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)
REACT:R-SSC-388468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR1A,B (Sus scrofa)
RHEA:26316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> dihydroxyacetone phosphate + L-aspartate 4-semialdehyde
REACT:R-HSA-5696146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC2 deaminates TYR (Homo sapiens)
RHEA:69884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(out) + 2 Na(+)(out) => L-ascorbate(in) + 2 Na(+)(in)
RHEA:47312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + L-serine(in) <=> L-phenylalanine(in) + L-serine(out)
REACT:R-SPO-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Schizosaccharomyces pombe)
REACT:R-BTA-210881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Tie2/Ang1 complex (Bos taurus)
REACT:R-DRE-193460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Danio rerio)
REACT:R-RNO-8950504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27 binds CRLF1 (Rattus norvegicus)
RHEA:17608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine <=> ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate
REACT:R-HSA-8848215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Homo sapiens)
REACT:R-BTA-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Bos taurus)
REACT:R-XTR-4546387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VDR with SUMO2 (Xenopus tropicalis)
REACT:R-SCE-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Saccharomyces cerevisiae)
REACT:R-HSA-975878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR (Homo sapiens)
REACT:R-MMU-917839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-Transferrin dissociates from the receptor complex (Mus musculus)
RHEA:47871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-(9Z)-octadecenoylglycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
RHEA:69579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+) <=> (R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2
RHEA:35712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + succinyl-CoA => acetyl-CoA + succinate
RHEA:65690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine
RHEA:45142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-glutamyl-[protein] + O2 + phylloquinol => 2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O
REACT:R-MMU-8855131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9 binds Clathrin-coated vesicles (Mus musculus)
REACT:R-SSC-8938951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PAX5 (BSAP) (Sus scrofa)
REACT:R-GGA-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Gallus gallus)
RHEA:39457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH
REACT:R-BTA-909729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JAK kinases (Bos taurus)
REACT:R-BTA-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Bos taurus)
REACT:R-CFA-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Canis familiaris)
REACT:R-GGA-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Gallus gallus)
REACT:R-GGA-9714361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC activates endoplasmic reticulum effectors (Gallus gallus)
REACT:R-XTR-5632738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDIT4 binds 14-3-3 dimer (Xenopus tropicalis)
REACT:R-RNO-174438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate on the C-strand (Rattus norvegicus)
RHEA:67739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-neuraminate <=> aceneuramate
REACT:R-DRE-71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Danio rerio)
REACT:R-HSA-1973968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 4A and 103 bind CCR2 (Homo sapiens)
REACT:R-XTR-9034855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK3 (Xenopus tropicalis)
RHEA:69638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
RHEA:22958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:0004704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK
GO:0004704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB-inducing kinase activity
RHEA:54044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = 7-epi-alpha-eudesmol + diphosphate
RHEA:54044	skos:prefLabel	"7-epi-alpha-eudesmol synthase"
RHEA:54044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-epi-alpha-eudesmol synthase"
REACT:R-RNO-9687625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds MLKL (Rattus norvegicus)
REACT:R-SCE-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Saccharomyces cerevisiae)
REACT:R-BTA-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Bos taurus)
REACT:R-HSA-8848314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36:IL1RL2 binds IL1RAP-1 (Homo sapiens)
REACT:R-DRE-6809720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM1:MTMR12 (Danio rerio)
REACT:R-CEL-2046096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Caenorhabditis elegans)
RHEA:49009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADPH + O2 => aurachin C epoxide + H2O + NADP(+)
RHEA:71238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] <=> [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]
RHEA:71580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP(out) + CDP-L-ribitol(in) => CDP(in) + CDP-L-ribitol(out)
RHEA:53365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(47) in tRNA + NAD(+) => H(+) + NADH + uridine(47) in tRNA
REACT:R-BTA-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Bos taurus)
REACT:R-HSA-373716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacting NCK-1 (Homo sapiens)
REACT:R-PFA-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Plasmodium falciparum)
RHEA:51324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 = (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate
REACT:R-BTA-428749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-proten Gq (Bos taurus)
GO:0140567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane protein dislocase activity
GO:0140567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate
GO:0140567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transmembrane helix dislocase
REACT:R-MMU-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Mus musculus)
RHEA:42994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-nephthenol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O
REACT:R-GGA-388529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholecystokinin receptors bind cholecystokinin (Gallus gallus)
RHEA:58026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oleanolate 3-O-beta-D-glucoside + UDP => oleanolate + UDP-alpha-D-glucose
RHEA:54887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + NADP(+) <=> H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
REACT:R-RNO-6807866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the ERGIC (Rattus norvegicus)
RHEA:25542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ent-pimara-8(14),15-diene => ent-copalyl diphosphate
GO:0052794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-alpha-(2->3)-sialidase activity
GO:0052794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-alpha-2,3-sialidase activity
GO:0052794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-alpha-(2,3)-sialidase activity
REACT:R-HSA-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Homo sapiens)
RHEA:52417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-O-phospho-D-erythronate + H(+) => CO2 + dihydroxyacetone phosphate
RHEA:10867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 <=> 2-(acetamidomethylene)succinate + NADP(+)
REACT:R-HSA-4332359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active calmodulin binds CAMK2 (Homo sapiens)
REACT:R-RNO-5357432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL binds SRC-1 (Rattus norvegicus)
RHEA:22611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + succinate
RHEA:14588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-997314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of JAK1 by SHP1 (Xenopus tropicalis)
REACT:R-CFA-6795460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK1 phosphorylates MDM2 (Canis familiaris)
REACT:R-CFA-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Canis familiaris)
RHEA:35371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate
REACT:R-CFA-2467809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)
RHEA:41473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]
RHEA:42756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42756	skos:prefLabel	"16S rRNA (cytosine(1407)-C(5))-methyltransferase"
RHEA:42756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (cytosine(1407)-C(5))-methyltransferase"
REACT:R-HSA-3000263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN2:RCbl is degraded to release RCbl (Homo sapiens)
REACT:R-RNO-109700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT2 binds PIP3 (Rattus norvegicus)
GO:0102402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity
REACT:R-MMU-6781922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds UFD1L:SKP2 (Mus musculus)
RHEA:34764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate(out) + succinate(in) => (S,S)-tartrate(in) + succinate(out)
REACT:R-RNO-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Rattus norvegicus)
RHEA:54917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol + NADP(+) => 9-cis-retinal + H(+) + NADPH
REACT:R-RNO-189208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Rattus norvegicus)
RHEA:18797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5649800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)
REACT:R-DRE-8857925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Danio rerio)
REACT:R-MMU-429798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Mus musculus)
RHEA:11822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide => diphthamide-[translation elongation factor 2] + NAD(+)
RHEA:55937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-hydroxyretinol + NAD(+) => all-trans-4-hydroxyretinal + H(+) + NADH
REACT:R-GGA-6783670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1 binds CLCF1 (Gallus gallus)
GO:0102610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-secoisolariciresinol glucosyltransferase activity
RHEA:55726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]
RHEA:60836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-adenosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate
GO:0004890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ionotropic GABA receptor activity
GO:0004890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA-A receptor activity
REACT:R-RNO-4551768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO2,3 (Rattus norvegicus)
REACT:R-HSA-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Homo sapiens)
REACT:R-SSC-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Sus scrofa)
RHEA:51886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-proline betaine => L-proline betaine
REACT:R-GGA-9007447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 forms the PRC1L4 complex (Gallus gallus)
RHEA:25072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoyl-CoA + AMP + diphosphate => 3-hydroxybenzoate + ATP + CoA
RHEA:66848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Cu(2+) + NADH = 2 Cu(+) + H(+) + NAD(+)
RHEA:35801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O
RHEA:45401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:61315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Mus musculus)
GO:0016463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Zn2+-exporting ATPase activity
GO:0016463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P1B-type ATPase activity
GO:0016463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc transmembrane transporter activity, phosphorylative mechanism
GO:0016463	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	zinc exporting ATPase activity
GO:0016463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc-translocating P-type ATPase activity
GO:0016463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc-exporting ATPase activity
GO:0016463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP phosphohydrolase (Zn2+-exporting)
GO:0016463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type zinc transporter activity
GO:0016463	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P(1B)-type ATPase activity
GO:0016463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Zn(2+)-exporting ATPase activity
REACT:R-DME-538891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes (Drosophila melanogaster)
RHEA:54321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:11868	skos:prefLabel	"D-arabinitol dehydrogenase (NADP(+))"
RHEA:11868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NADP(+) = D-ribulose + H(+) + NADPH
RHEA:11868	skos:altLabel	"D-arabinitol dehydrogenase 1"
RHEA:11868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arabinitol dehydrogenase (NADP(+))"
RHEA:11868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NADP(+) = D-xylulose + H(+) + NADPH
RHEA:11868	skos:altLabel	"NADP(+)-dependent D-arabinitol dehydrogenase"
REACT:R-MMU-5250947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH complex binds rDNA promoter (Mus musculus)
REACT:R-XTR-389632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)
REACT:R-PFA-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Plasmodium falciparum)
REACT:R-RNO-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Rattus norvegicus)
RHEA:23008	skos:altLabel	"trehalose-6-phosphate hydrolase"
RHEA:23008	skos:prefLabel	"alpha,alpha-phosphotrehalase"
RHEA:23008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate
RHEA:23008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha,alpha-phosphotrehalase"
REACT:R-HSA-9011971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive MYB gene expression (Homo sapiens)
RHEA:51871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + umbelliferone <=> demethylsuberosin + diphosphate
REACT:R-HSA-1067640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R-2 (Homo sapiens)
RHEA:16821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NAD(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADH
REACT:R-HSA-9619838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARC binds DNM2 and SH3GL3 (Homo sapiens)
REACT:R-DRE-9014454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG translocates to the ER membrane (Danio rerio)
RHEA:62260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + Mn(2+)(out) = 2 hydrogencarbonate(in) + Mn(2+)(in)
RHEA:12453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
REACT:R-DRE-3232162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates MITF with SUMO1 (Danio rerio)
GO:0017171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine hydrolase activity
REACT:R-MMU-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Mus musculus)
GO:0008417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Homo sapiens)
GO:0008417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucosyltransferase activity
REACT:R-HSA-9009533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)
RHEA:54131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP
RHEA:64995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine
REACT:R-SSC-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Sus scrofa)
GO:0140903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine N-methyltransferase activity (H3-R26 specific)
GO:0140903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R26 methyltransferase activity
GO:0140903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H3-R26 specific)
GO:0140903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R26 arginine methyltransferase activity
GO:0140903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3R26 methyltransferase activity
GO:0140903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-R26 specific)
RHEA:15316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine <=> acetaldehyde + NH4(+)
REACT:R-RNO-6785342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Rattus norvegicus)
REACT:R-HSA-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
RHEA:11221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine
RHEA:21855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-10-hydroxyoctadecanoate <=> (9Z)-octadecenoate + H2O
RHEA:48852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
RHEA:55192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 = 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate
RHEA:49359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:38487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)
REACT:R-BTA-388560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA,EDNRB bind EDNs (Bos taurus)
REACT:R-RNO-9727198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
RHEA:48342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty acyl-CoA + AMP + diphosphate => a medium chain fatty acid + ATP + CoA
REACT:R-CFA-3343700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
REACT:R-HSA-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Homo sapiens)
REACT:R-XTR-2395849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
REACT:R-DRE-2029475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of AA by iPLA2 upon FCGR activation (Danio rerio)
RHEA:70946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(in) <=> L-isoleucine(out)
RHEA:63505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daunorubicin + H(+) + NADPH => 13-dihydrodaunorubicin + NADP(+)
REACT:R-SSC-5340214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB binds O2 (Sus scrofa)
REACT:R-HSA-6805122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB binds TP53 (Homo sapiens)
GO:0044667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-carnitine:4-(trimethylammonio)butanoate antiporter activity
GO:0044667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-carnitine:gamma-butyrobetaine antiporter activity
GO:0044667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine:gamma-butyrobetaine antiporter activity
GO:0044667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)
GO:0044667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
RHEA:68847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> (Z)-alpha-bisabolene + diphosphate
REACT:R-SPO-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Schizosaccharomyces pombe)
REACT:R-HSA-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Homo sapiens)
RHEA:58067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin <=> 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:58448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine
EC:1.14.13.178	skos:prefLabel	"methylxanthine N(1)-demethylase"
EC:1.14.13.178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylxanthine N(1)-demethylase"
REACT:R-CEL-9653514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17L2 deubiquitinates RCE1 (Caenorhabditis elegans)
RHEA:68969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mandelate + O2 => H2O2 + phenylglyoxylate
REACT:R-DRE-6786095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates STAT3,STAT6 (Danio rerio)
RHEA:68100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + xylitol = H(+) + L-xylulose + NADH
GO:0008725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-3-methyladenine glycosidase I activity
GO:0008725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyladenine DNA glycosylase I
GO:0008725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA glycosidase I activity
GO:0008725	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
GO:0008725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-3-methyladenine glycosylase I activity
GO:0008725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-3-methyladenine glycosylase activity
GO:0008725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleate 3-methyladenine glycosidase I
REACT:R-MMU-452091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IL2RB Y338 enables SHC recruitment (Mus musculus)
REACT:R-DRE-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Danio rerio)
REACT:R-HSA-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Homo sapiens)
RHEA:31051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-beta-leucine + H2O + NAD(+) = 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)
REACT:R-CFA-141156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL-mediated dimerization of procaspase-8 (Canis familiaris)
RHEA:39347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)
REACT:R-HSA-9694392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3a translocates to the ERGIC (Homo sapiens)
REACT:R-PFA-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Plasmodium falciparum)
RHEA:59590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-alanyl-L-ornithine + H(+) + phosphate => ATP + beta-alanine + L-ornithine
REACT:R-RNO-9668419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Rattus norvegicus)
REACT:R-HSA-2161794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is converted to HXA3/B3 by ALOX12 (Homo sapiens)
RHEA:70354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O <=> beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose
GO:0052676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanal reductase (NAD) activity
GO:0052676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methylbutanol:NAD+ oxidoreductase activity
GO:0052676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutyraldehyde reductase (NAD) activity
GO:0052676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoamyl alcohol oxidase (NAD) activity
GO:0052676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol:NAD oxidoreductase activity
RHEA:20712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-CoA + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + CoA
RHEA:11073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 3 H(+) + NADPH + O2 => catechol + CO2 + NADP(+) + NH4(+)
RHEA:13419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + xanthommatin => 5,12-dihydroxanthommatin + NAD(+)
REACT:R-SSC-450550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCalpha phosphorylates HuR (Sus scrofa)
RHEA:30807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH
REACT:R-CFA-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Canis familiaris)
REACT:R-MMU-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Mus musculus)
REACT:R-RNO-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)
RHEA:29275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(in) + Na(+)(in) = L-isoleucine(out) + Na(+)(out)
REACT:R-CEL-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Caenorhabditis elegans)
GO:0051061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP reduction
GO:0051061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dADP + H2O = [thioredoxin]-dithiol + ADP
GO:0051061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP reductase activity
REACT:R-DRE-8940959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurolysin degrades neurotensin (Danio rerio)
REACT:R-SCE-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Saccharomyces cerevisiae)
REACT:R-CEL-9654521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin dissociates KRAS4B from the plasma membrane (Caenorhabditis elegans)
REACT:R-DME-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Drosophila melanogaster)
REACT:R-GGA-1227753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization (Gallus gallus)
RHEA:45152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol
REACT:R-RNO-5626316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Rattus norvegicus)
RHEA:60250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] => A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]
REACT:R-GGA-2537665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin-1 and -2 bind fibronectin (Gallus gallus)
REACT:R-GGA-182969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:CBL) (Gallus gallus)
REACT:R-SSC-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Sus scrofa)
RHEA:31737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 3-oxocholan-24-oyl-CoA + NAD(+)
GO:0102220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogenase activity (NAD+, ferredoxin)
REACT:R-MMU-5336182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37 binds prosaptide (Mus musculus)
REACT:R-MMU-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Mus musculus)
RHEA:24838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate
RHEA:63486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein] => 2-oxoglutarate + L-prolyl-[protein] + O2
GO:0044022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serine kinase activity (H3-S28 specific)
GO:0044022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-serine kinase activity (H3-S28 specific)
GO:0044022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3S28 kinase activity
GO:0044022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H3-S28 specific)
REACT:R-SSC-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)
REACT:R-BTA-379387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DA to form 3MT (Bos taurus)
RHEA:37757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA
REACT:R-RNO-5624956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds INPP5E (Rattus norvegicus)
REACT:R-DDI-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Dictyostelium discoideum)
RHEA:37528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
GO:0051734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity
GO:0051734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent polynucleotide 5'-hydroxyl-kinase activity
GO:0051734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polynucleotide kinase activity
GO:0051734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:5'-dephosphopolynucleotide 5'-phosphatase activity
GO:0051734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent polynucleotide kinase activity
REACT:R-RNO-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)
RHEA:52436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA
REACT:R-CFA-391936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP1 receptor can bind PGE2 (Canis familiaris)
REACT:R-DRE-5617815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binds RAB3IP (Danio rerio)
RHEA:71418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)
RHEA:37941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
REACT:R-HSA-977615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates MCP/CR1-bound C4b/C3b (Homo sapiens)
REACT:R-XTR-1297444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of cAMP to HCN channels (Xenopus tropicalis)
REACT:R-DME-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Drosophila melanogaster)
REACT:R-HSA-216756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)
REACT:R-HSA-9640307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeHA hydrolyses to 2,3-DKG (Homo sapiens)
RHEA:55154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein] => H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein]
REACT:R-CEL-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Caenorhabditis elegans)
REACT:R-SSC-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Sus scrofa)
REACT:R-CFA-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Canis familiaris)
RHEA:61673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-cysteine => diphosphate + L-cysteinyl-5'-AMP
REACT:R-HSA-9684309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3CLp cleaves nsp6-11 (Homo sapiens)
REACT:R-RNO-76386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 S-demethylates 6MMP (Rattus norvegicus)
RHEA:33032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-fructose + NADH => D-sorbitol + NAD(+)
REACT:R-XTR-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Xenopus tropicalis)
REACT:R-XTR-8875482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin to ubiquitinated MET (Xenopus tropicalis)
REACT:R-MMU-9029690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-6 translocates to the nucleus (Mus musculus)
REACT:R-DDI-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Dictyostelium discoideum)
RHEA:52563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-erythronate <=> 3-dehydro-D-erythronate
RHEA:56544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-GGA-2730899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BCL10 and MALT1 (Gallus gallus)
GO:0103091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(7'-methylthio)heptylmalate synthase activity
GO:0008517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate transmembrane transporter activity
GO:0008517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate transporter activity
GO:0008517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folic acid transmembrane transporter activity
GO:0008517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B9 transporter activity
GO:0008517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Homo sapiens)
GO:0008517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folic acid transporter activity
GO:0008517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin M transporter activity
GO:0050226	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS:psychosine sulphotransferase activity
GO:0050226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	psychosine sulphotransferase activity
GO:0050226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine = 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
GO:0050226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"psychosine sulfotransferase"
GO:0050226	skos:prefLabel	"psychosine sulfotransferase"
GO:0050226	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity
GO:0050226	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity
GO:0050226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	psychosine sulfotransferase activity
REACT:R-MMU-5661122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2R3-histone H3 (Mus musculus)
REACT:R-MMU-203662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Mus musculus)
RHEA:24611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate + H(+) <=> 2,5-dioxopentanoate + CO2 + H2O
REACT:R-DRE-2213239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MHC II alpha beta heterodimer (Danio rerio)
RHEA:26237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeraniol + diphosphate
RHEA:26237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranylgeranyl diphosphate diphosphatase"
RHEA:26237	skos:altLabel	"geranylgeranyl diphosphate phosphatase"
RHEA:26237	skos:prefLabel	"geranylgeranyl diphosphate diphosphatase"
RHEA:68373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine + pyruvate => 2-oxosuccinamate + L-alanine
RHEA:13349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonate + S-adenosyl-L-methionine = methyl (-)-jasmonate + S-adenosyl-L-homocysteine
RHEA:13349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"jasmonate O-methyltransferase"
RHEA:13349	skos:prefLabel	"jasmonate O-methyltransferase"
RHEA:13349	skos:altLabel	"jasmonic acid carboxyl methyltransferase"
RHEA:68629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]
REACT:R-SPO-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Schizosaccharomyces pombe)
RHEA:37675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:60769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2-oxoglutarate + gibberellin A12 + 3 O2 => 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate
RHEA:28280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-alanine + sulfite => 3-sulfino-L-alanine + H2O
REACT:R-SCE-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Saccharomyces cerevisiae)
RHEA:31308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:36044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-8'-apo-beta-carotenal + O2 => 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial
REACT:R-BTA-74059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Bos taurus)
GO:0070747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-35R
GO:0070747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-35 receptor activity
GO:0070747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-35 receptor activity
GO:0047352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylylsulfate:ammonia adenylyltransferase activity
GO:0047352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylylsulphate-ammonia adenylyltransferase activity
GO:0047352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APSAT
GO:0047352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylylsulfate-ammonia adenylyltransferase activity
REACT:R-DRE-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Danio rerio)
REACT:R-XTR-8937177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD binds ARNT (Xenopus tropicalis)
REACT:R-DME-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Drosophila melanogaster)
REACT:R-XTR-751027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Xenopus tropicalis)
REACT:R-SSC-5609665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
RHEA:23160	skos:altLabel	"rhamnose isomerase"
RHEA:23160	skos:prefLabel	"L-rhamnose isomerase"
RHEA:23160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-rhamnose isomerase"
RHEA:23160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnopyranose = L-rhamnulose
REACT:R-SSC-173512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Sus scrofa)
REACT:R-XTR-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Xenopus tropicalis)
REACT:R-DRE-5665727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds CDC42:GTP (Danio rerio)
RHEA:18263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine => H2O + precorrin-5 + S-adenosyl-L-methionine
REACT:R-DDI-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)
REACT:R-HSA-9705461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT1,3,5 dimer binds SOCS1 gene (Homo sapiens)
RHEA:67381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-cysteine => L-alanine + L-cysteine
GO:0055100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adiponectin binding
REACT:R-CEL-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Caenorhabditis elegans)
REACT:R-DRE-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)
REACT:R-CEL-169905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS is phosphorylated by active TrkA receptor (Caenorhabditis elegans)
REACT:R-XTR-202472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TRAF6 to CBM complex (Xenopus tropicalis)
REACT:R-MMU-4655355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Mus musculus)
REACT:R-MMU-5689649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 (Mus musculus)
REACT:R-CFA-5693608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial resection of double-strand break ends (Canis familiaris)
REACT:R-HSA-9701562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD274 gene expression downstream of ALK signaling (Homo sapiens)
GO:0030944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDEL sequence binding
RHEA:58316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
REACT:R-HSA-397835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:Gq (active) dissociate (Homo sapiens)
RHEA:71380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) => D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)
REACT:R-DDI-9025152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Dictyostelium discoideum)
REACT:R-CFA-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Canis familiaris)
REACT:R-BTA-8936519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO2:FAD dimer reduces quinones to hydroquinones (Bos taurus)
REACT:R-SCE-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Saccharomyces cerevisiae)
REACT:R-MMU-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Mus musculus)
RHEA:56015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)
REACT:R-HSA-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Homo sapiens)
REACT:R-HSA-1168638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated IKK phosphorylates I-kappaB (Homo sapiens)
REACT:R-SSC-193369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Sus scrofa)
RHEA:65787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA
REACT:R-CFA-1475422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPS is phosphorylated by cGMP-dependant protein kinase II (Canis familiaris)
REACT:R-CEL-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)
REACT:R-SPO-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Schizosaccharomyces pombe)
RHEA:29155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) = 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)
REACT:R-HSA-1237059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ dehydrates HCO3- to CO2 (Homo sapiens)
REACT:R-XTR-8981657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds PTPRZ1 (Xenopus tropicalis)
REACT:R-DRE-4754176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR3-histone H3 (Danio rerio)
GO:0051998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein carboxyl methyltransferase activity
GO:0051998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein carboxyl O-methyltransferase activity
REACT:R-HSA-2530445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD59 inhibits MAC formation (Homo sapiens)
REACT:R-CFA-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Canis familiaris)
RHEA:12963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + butanoate => acetoacetate + butanoyl-CoA
REACT:R-DRE-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Danio rerio)
REACT:R-HSA-449829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11 binds IL11RA (Homo sapiens)
REACT:R-RNO-6784006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Rattus norvegicus)
REACT:R-GGA-8938773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A polyubiquitinates PRKDC (Gallus gallus)
RHEA:16267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate
REACT:R-SPO-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Schizosaccharomyces pombe)
RHEA:32610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-hydroxygeranial + H(+) + NADPH
RHEA:21012	skos:altLabel	"poly(ribitol-phosphate) N-acetylglucosaminyltransferase"
RHEA:21012	skos:altLabel	"UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase"
RHEA:21012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
RHEA:21012	skos:prefLabel	"poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase"
RHEA:21012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase"
RHEA:39857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol
RHEA:62112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-D-aspartate = H2O + iminosuccinate
REACT:R-DRE-211904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F12 18-hydroxylates ARA (Danio rerio)
REACT:R-DRE-2187358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters unphosphorylated SMAD2/3 (Danio rerio)
REACT:R-RNO-5625797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Rattus norvegicus)
REACT:R-HSA-8950721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Programmed cell death protein 4 (Homo sapiens)
REACT:R-HSA-1222686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric oxide diffuses into the phagosome (Homo sapiens)
GO:0052633	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
GO:0052633	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cis-aconitase activity
GO:0052633	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aconitate hydratase activity
GO:0052633	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	citrate hydro-lyase activity
GO:0052633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate hydro-lyase (cis-aconitate-forming) activity
GO:0052633	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	citrate(isocitrate) hydro-lyase activity
RHEA:13606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + O2 => 2 H2O + 2 L-dehydroascorbate
RHEA:19956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-alanine <=> an L-alpha-amino acid + pyruvate
REACT:R-MMU-5628871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 promotes EP300-mediated acetylation of TP53 (Mus musculus)
RHEA:45208	skos:prefLabel	"[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase"
RHEA:45208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase"
RHEA:45208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] = Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M
RHEA:57600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:28081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + NAD(+) <=> H(+) + NADH + phosphonoacetaldehyde
REACT:R-SSC-139970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO3:FAD N-oxidises TMA to TMAO (Sus scrofa)
RHEA:12506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH => (3R)-1,4-thiomorpholine-3-carboxylate + NAD(+)
RHEA:56437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-MMU-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Mus musculus)
REACT:R-XTR-70355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALK1 phosphorylates Gal to Gal1P (Xenopus tropicalis)
RHEA:36220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-BTA-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Bos taurus)
RHEA:12979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + phosphate => H2O + N-phosphocreatine
REACT:R-SSC-1022129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Sus scrofa)
RHEA:16392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + hydroquinone + NAD(+)
RHEA:69404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil(in) = uracil(out)
REACT:R-BTA-193424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
REACT:R-DME-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Drosophila melanogaster)
REACT:R-RNO-5668605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2:GTP binds NOX2 complex (Rattus norvegicus)
REACT:R-XTR-1234183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)
RHEA:54438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2
REACT:R-DRE-211966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2D6 4-hydroxylates debrisoquine (Danio rerio)
REACT:R-GGA-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Gallus gallus)
REACT:R-XTR-9759549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Xenopus tropicalis)
RHEA:41625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfinopropanoyl-CoA + H2O => H(+) + propanoyl-CoA + sulfite
RHEA:27889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-AMP + H2O <=> 3'-AMP + H(+)
GO:0061752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TERRA binding
GO:0061752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomeric repeat-containing RNA binding
REACT:R-HSA-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Homo sapiens)
REACT:R-GGA-5362437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are bound by lectins (Gallus gallus)
REACT:R-HSA-508513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B binds JAK3 (Homo sapiens)
RHEA:52343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] <=> AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]
REACT:R-GGA-209536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkB is ubiquitinated and degraded (Gallus gallus)
RHEA:33906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pseudooxynicotine <=> 4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine
REACT:R-XTR-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)
RHEA:29635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaose + H2O = alpha-D-glucose + D-maltotetraose
REACT:R-RNO-202704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaXbeta2 binds JAM3 (Rattus norvegicus)
RHEA:56716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] = H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate
REACT:R-CFA-1251997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ERBB4m80 by gamma-scretase complex (Canis familiaris)
REACT:R-SSC-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Sus scrofa)
REACT:R-DRE-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Danio rerio)
REACT:R-SPO-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Schizosaccharomyces pombe)
REACT:R-BTA-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Bos taurus)
REACT:R-CEL-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Caenorhabditis elegans)
REACT:R-BTA-5603114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)
REACT:R-DRE-202721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 binds JAM3 (Danio rerio)
REACT:R-HSA-5678418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol (Homo sapiens)
REACT:R-CFA-194023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2,HSD11B1 dimer oxidise CORT to COR (Canis familiaris)
REACT:R-SPO-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Schizosaccharomyces pombe)
GO:0019172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-lactate dehydratase"
GO:0019172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lactate dehydratase
GO:0019172	skos:altLabel	"glyoxylase III"
GO:0019172	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione-independent glyoxalase activity
GO:0019172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxalase III activity
GO:0019172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate hydro-lyase
GO:0019172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylglyoxal = (R)-lactate + H(+)
GO:0019172	skos:prefLabel	"D-lactate dehydratase"
RHEA:50070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glycoursodeoxycholate(in) + H2O
REACT:R-HSA-164510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conformational change in gp120 of Env oligomer (Homo sapiens)
RHEA:25269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine
GO:0000402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crossed form Holliday junction binding
GO:0000402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crossed form four-way junction DNA binding
RHEA:25940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-chloroquinoline + A + H2O = 8-chloroquinolin-2(1H)-one + AH2
RHEA:66804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate
RHEA:33212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) => 2-demethylmenaquinol-7 + CO2 + diphosphate
EC:3.4.22.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin L"
EC:3.4.22.15	skos:prefLabel	"cathepsin L"
REACT:R-HSA-9701537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, S727 STAT3 dimer binds CD274 gene (Homo sapiens)
RHEA:40090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-hydroxydocosanoate + NAD(+) <=> 22-oxodocosanoate + H(+) + NADH
RHEA:24377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
REACT:R-CFA-77254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Canis familiaris)
REACT:R-DRE-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Danio rerio)
REACT:R-MMU-5682607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Mus musculus)
REACT:R-XTR-1022133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)
EC:2.4.1.245	skos:altLabel	"trehalose synthetase"
EC:2.4.1.245	skos:prefLabel	"alpha,alpha-trehalose synthase"
EC:2.4.1.245	skos:altLabel	"trehalose synthase"
EC:2.4.1.245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha,alpha-trehalose synthase"
RHEA:60167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine
RHEA:47903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate
REACT:R-DRE-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)
GO:1990244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H2A-T120 specific)
GO:1990244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone threonine kinase activity (H2A-T120 specific)
GO:1990244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AT120 kinase activity
GO:1990244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A-T120 kinase activity
GO:0140797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-R17 arginine deiminase activity
GO:0140797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3-R17 citrullination
GO:0140797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine deiminase activity (H3-R17 specific)
GO:0140797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R17 arginine deiminase activity
REACT:R-BTA-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Bos taurus)
RHEA:36287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NADP(+)
REACT:R-DRE-1299338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRESK (Danio rerio)
REACT:R-HSA-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Homo sapiens)
REACT:R-SCE-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Saccharomyces cerevisiae)
REACT:R-XTR-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Xenopus tropicalis)
RHEA:63337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xylose => beta-D-xylose
RHEA:41800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:44687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine
RHEA:15093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
EC:2.7.11.22	skos:prefLabel	"cyclin-dependent kinase"
EC:2.7.11.22	skos:altLabel	"Cdk-activating protein kinase"
EC:2.7.11.22	skos:altLabel	"cdc2 kinase"
EC:2.7.11.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclin-dependent kinase"
EC:2.7.11.22	skos:altLabel	"cdk-activating kinase"
REACT:R-DRE-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Danio rerio)
RHEA:66311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)
RHEA:55234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2
RHEA:38150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon disulfide + H2O <=> carbonyl sulfide + H(+) + hydrogen sulfide
REACT:R-DRE-165026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Danio rerio)
REACT:R-DRE-5693373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Danio rerio)
RHEA:63467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + UTP <=> (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP
RHEA:29219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + sn-glycerol 3-phosphate = a menaquinol + dihydroxyacetone phosphate
RHEA:69530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+) => chorismate + H2O + 2 L-glutamine
REACT:R-RNO-8937767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 dephosphorylates RUNX1 (Rattus norvegicus)
RHEA:58036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = 8-epi-inunolide + H2O
GO:0004877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C3b receptor activity
RHEA:14462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose => (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP
REACT:R-XTR-3222072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAXX binds Ub-MDM2 and USP7 (Xenopus tropicalis)
RHEA:36176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkylglycerone 3-phosphate + H(+) + NADPH => 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)
RHEA:21273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione + spermidine => ADP + glutathionylspermidine + H(+) + phosphate
RHEA:39230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octacosenoyl-CoA + H(+) + NADPH <=> NADP(+) + octacosanoyl-CoA
RHEA:22795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isonocardicin A <=> nocardicin A
REACT:R-DME-8951676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TEADs and YAP1 (Drosophila melanogaster)
REACT:R-GGA-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Gallus gallus)
REACT:R-DRE-8982637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins binds G alpha-t (Danio rerio)
GO:0046480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactolipid galactosyltransferase activity
GO:0046480	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DGDG synthase activity
GO:0046480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity
GO:0046480	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	digalactosyldiacylglycerol synthase activity
GO:0046480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GGGT activity
GO:0046480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactolipid-galactolipid galactosyltransferase activity
GO:0046480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	interlipid galactosyltransferase activity
GO:0046480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactolipid:galactolipid galactosyltransferase activity
RHEA:14950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinoline-4-carboxylate => 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2
RHEA:19182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:63078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetylphloroglucinol + 3 CO2 + 4 CoA => acetyl-CoA + 3 H(+) + 3 malonyl-CoA
GO:0140784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal ion sensor activity
RHEA:28324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP + wogonin 7-O-beta-D-glucuronate => UDP-alpha-D-glucuronate + wogonin
RHEA:71809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide => a 2'-deoxyguanosine in DNA + NAD(+)
RHEA:45380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate
RHEA:57799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite
RHEA:66092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-kynurenine = H2O + kynurenate + L-phenylalanine
REACT:R-MMU-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Mus musculus)
REACT:R-CFA-389919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds pBTLA (Canis familiaris)
GO:0002162	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-dystroglycan binding
GO:0002162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dystroglycan binding
GO:0002162	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-dystroglycan binding
REACT:R-DME-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Drosophila melanogaster)
REACT:R-SSC-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Sus scrofa)
REACT:R-MMU-8853419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 promotes AURKA autophosphorylation (Mus musculus)
REACT:R-DRE-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Danio rerio)
REACT:R-XTR-266328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Xenopus tropicalis)
REACT:R-HSA-9013110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC binds effectors at the plasma membrane (Homo sapiens)
REACT:R-MMU-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Mus musculus)
RHEA:41656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + NADP(+) = NADPH + sanguinarine
RHEA:25672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + loliose + UDP => sucrose + UDP-alpha-D-galactose
GO:0030492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hemoglobin binding
GO:0030492	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	globin binding
GO:0030492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	haemoglobin binding
REACT:R-CEL-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)
GO:0047005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity
GO:0047005	skos:prefLabel	"16alpha-hydroxysteroid dehydrogenase"
GO:0047005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16alpha-hydroxy steroid dehydrogenase activity
GO:0047005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16alpha-hydroxysteroid dehydrogenase"
GO:0047005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16alpha-hydroxysteroid dehydrogenase activity
GO:0047005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-alpha-hydroxysteroid dehydrogenase activity
REACT:R-BTA-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)
REACT:R-DRE-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Danio rerio)
RHEA:70000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine(in) + Na(+)(in) => L-threonine(out) + Na(+)(out)
REACT:R-DDI-266050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to LTC4 by LTC4S (Dictyostelium discoideum)
RHEA:66345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate
REACT:R-DME-4085033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Drosophila melanogaster)
RHEA:20571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + urea => H2O + L-arginine
RHEA:22073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-ribulose => ADP + H(+) + L-ribulose 5-phosphate
REACT:R-CFA-2327733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 binds Collagen types I-V, VII (Canis familiaris)
RHEA:67690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate => 2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O
RHEA:24437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + methanophenazine => dihydromethanophenazine
REACT:R-HSA-375768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Homo sapiens)
GO:0031826	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2A serotonin receptor ligand
GO:0031826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 2A receptor binding
GO:0031826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2A serotonin receptor binding
REACT:R-RNO-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Rattus norvegicus)
REACT:R-DRE-352268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Satb1 (Danio rerio)
RHEA:66900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-tryptophan + malonyl-CoA = CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O
RHEA:58468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate
REACT:R-GGA-168947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand binds to TLR10 (Gallus gallus)
REACT:R-GGA-9633044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR binds STRN (Gallus gallus)
REACT:R-XTR-417898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y4 receptor can bind to UTP (Xenopus tropicalis)
REACT:R-CFA-209924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is decarboxylated to dopamine (Canis familiaris)
REACT:R-RNO-201475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with R-Smad1/5/8 for type I receptor (Rattus norvegicus)
RHEA:11511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartyl-[protein] + O2 <=> 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate
RHEA:13917	skos:altLabel	"monoterpenoid dehydrogenase"
RHEA:13917	skos:prefLabel	"(-)-menthol dehydrogenase"
RHEA:13917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-menthol dehydrogenase"
RHEA:13917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH
RHEA:70702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) <=> H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)
REACT:R-RNO-183089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds and ubiquitinates phosphorylated Sprouty (Rattus norvegicus)
REACT:R-DDI-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
REACT:R-BTA-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)
REACT:R-GGA-8875531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS4 (Gallus gallus)
RHEA:36329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate => ADP + dimethylallyl diphosphate
REACT:R-HSA-6786171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)
REACT:R-GGA-419152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate (Gallus gallus)
REACT:R-MMU-879907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate the receptor (Mus musculus)
REACT:R-SSC-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Sus scrofa)
RHEA:44512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine
GO:0050134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(6)-methyllysine oxidase activity
GO:0050134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-methyl-lysine oxidase activity
GO:0050134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)
GO:0050134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)
GO:0050134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-methyllysine oxidase activity
GO:0050134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epsilon-N-methyllysine demethylase activity
GO:0050134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epsilon-alkyllysinase activity
GO:0050134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epsilon-alkyl-L-lysine:oxygen oxidoreductase activity
REACT:R-RNO-162721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Rattus norvegicus)
REACT:R-MMU-8941234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Mus musculus)
EC:3.1.26.10	skos:prefLabel	"ribonuclease IX"
EC:3.1.26.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease IX"
RHEA:54572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in tRNA = a pseudouridine in tRNA
REACT:R-XTR-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Xenopus tropicalis)
REACT:R-DME-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Drosophila melanogaster)
RHEA:62258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(in) + 2 hydrogencarbonate(in) => Cd(2+)(out) + 2 hydrogencarbonate(out)
REACT:R-MMU-2730902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of p-CARMA1 (Mus musculus)
RHEA:57151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
RHEA:51145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 => (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate
RHEA:33632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + octanoate => AMP + diphosphate + octanoyl-CoA
GO:0015120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglycerate transmembrane transporter activity
REACT:R-PFA-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Plasmodium falciparum)
REACT:R-DME-4551679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO2 (Drosophila melanogaster)
RHEA:43221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:65633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + tetracosanoyl-CoA => an N-tetracosanoyl-sphingoid base + CoA + H(+)
RHEA:36751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,4-galactosyltransferase"
RHEA:36751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:36751	skos:prefLabel	"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,4-galactosyltransferase"
REACT:R-SCE-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Saccharomyces cerevisiae)
REACT:R-HSA-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Homo sapiens)
REACT:R-GGA-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Gallus gallus)
EC:1.3.1.48	skos:altLabel	"15-oxo-Delta(13)-prostaglandin reductase"
EC:1.3.1.48	skos:prefLabel	"15-oxoprostaglandin 13-reductase"
EC:1.3.1.48	skos:altLabel	"prostaglandin 13-reductase"
EC:1.3.1.48	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"15-oxoprostaglandin 13-reductase"
REACT:R-BTA-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Bos taurus)
REACT:R-DDI-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Dictyostelium discoideum)
RHEA:29356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + H2O => 2'-deoxyuridine + phosphate
RHEA:59205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)
REACT:R-GGA-212380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TRAP coactivator complex (Gallus gallus)
REACT:R-MMU-5666169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)
REACT:R-CFA-141341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMOX-3 oxidises SPN to SPM (Canis familiaris)
RHEA:35853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA
REACT:R-RNO-450292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Rattus norvegicus)
RHEA:14197	skos:prefLabel	"aspartate--ammonia ligase (ADP-forming)"
RHEA:14197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + NH4(+) = ADP + H(+) + L-asparagine + phosphate
RHEA:14197	skos:altLabel	"asparagine synthetase (ADP-forming)"
RHEA:14197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate--ammonia ligase (ADP-forming)"
REACT:R-CFA-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Canis familiaris)
RHEA:21597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH
REACT:R-BTA-3240957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PRC2-EZH2 complex (Bos taurus)
REACT:R-CFA-5686657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC1:XPF cleaves flaps generated by SSA (Canis familiaris)
REACT:R-BTA-8849428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 binds PTK6 (Bos taurus)
REACT:R-RNO-1112703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 is phosphorylated (Rattus norvegicus)
REACT:R-XTR-418576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 1:Gq complex (Xenopus tropicalis)
REACT:R-XTR-8852200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of LCK by PTPN22 (Xenopus tropicalis)
REACT:R-RNO-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Rattus norvegicus)
REACT:R-DRE-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Danio rerio)
REACT:R-SSC-6807106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN undergoes monoubiquitination (Sus scrofa)
GO:0102141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity
GO:0047003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-L-talose 4-dehydrogenase activity
GO:0047003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)
GO:0047003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity
GO:0047003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphospho-6-deoxy-L-talose dehydrogenase activity
GO:0047003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDP-6-deoxy-L-talose dehydrogenase activity
RHEA:32703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"copal-8-ol diphosphate hydratase"
RHEA:32703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O = 8-hydroxycopalyl diphosphate
RHEA:32703	skos:prefLabel	"copal-8-ol diphosphate hydratase"
REACT:R-CFA-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Canis familiaris)
RHEA:17882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-sulfo-D-glucosamine => D-glucosamine + sulfate
RHEA:15005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gibberellin 2beta-dioxygenase"
RHEA:15005	skos:altLabel	"gibberellin 2beta-hydroxylase"
RHEA:15005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A1 + O2 = CO2 + gibberellin A8 + succinate
RHEA:15005	skos:prefLabel	"gibberellin 2beta-dioxygenase"
REACT:R-DRE-140870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Danio rerio)
RHEA:47221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0001637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled chemoattractant receptor activity
GO:0001637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled chemoattractant receptor activity
GO:0001637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein chemoattractant receptor activity
GO:0001637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein chemoattractant receptor activity
REACT:R-SSC-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Sus scrofa)
REACT:R-XTR-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)
REACT:R-BTA-8987202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)
REACT:R-SSC-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Sus scrofa)
RHEA:20311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + O2 => 2 H2O2
RHEA:49154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine
RHEA:29310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + methanesulfonate + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + sulfite
REACT:R-CEL-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Caenorhabditis elegans)
RHEA:52297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6798374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DYRK2 phosphorylates TP53 (Homo sapiens)
REACT:R-DRE-5218818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Danio rerio)
REACT:R-GGA-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Gallus gallus)
REACT:R-DRE-1474213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP1,8,9,13 (Danio rerio)
GO:0102087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-benzoyl-L-glutamate synthetase activity
REACT:R-MMU-265429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Mus musculus)
REACT:R-SSC-212356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL-NICD coactivator complex (Sus scrofa)
RHEA:15858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) => 17alpha-hydroxyprogesterone + H(+) + NADPH
REACT:R-XTR-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Xenopus tropicalis)
GO:0047241	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity
GO:0047241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GO:0047241	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ManNAcA transferase activity
GO:0047241	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity
GO:0047241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS N-acetylmannosaminouronosyltransferase activity
RHEA:58113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1''-O-acetyl-ADP-alpha-D-ribose + H2O => acetate + ADP-D-ribose + H(+)
RHEA:47833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a + H2O => ganglioside GM1 + N-acetylneuraminate
REACT:R-HSA-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Homo sapiens)
REACT:R-RNO-9613570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Rattus norvegicus)
REACT:R-CFA-1222376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide from oxygen (Canis familiaris)
REACT:R-XTR-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Xenopus tropicalis)
RHEA:51813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)
REACT:R-HSA-76373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxylation of 4-aminobiphenyl (Homo sapiens)
REACT:R-SSC-176631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Sus scrofa)
RHEA:13542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetrathionate => H(+) + sulfate + sulfur + thiosulfate
REACT:R-DME-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Drosophila melanogaster)
RHEA:64629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + octan-1-ol => CoA + octyl acetate
RHEA:20032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxysarpagine + NADP(+) <=> H(+) + NADPH + vellosimine
RHEA:46555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0070336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flap-structured DNA binding
REACT:R-GGA-9753676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1,2 acetylate APAP-Cys to APAP-Mer (Gallus gallus)
REACT:R-GGA-5687484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Gallus gallus)
REACT:R-XTR-140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequestered tissue factor -> tissue factor (Xenopus tropicalis)
REACT:R-XTR-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Xenopus tropicalis)
REACT:R-HSA-5692768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates KALRN (Homo sapiens)
REACT:R-BTA-5671763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates PPP1R14A (Bos taurus)
REACT:R-DRE-389652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Danio rerio)
RHEA:34721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-13-methyltetradecenal + phosphoethanolamine => 15-methylhexadecasphing-4-enine 1-phosphate
REACT:R-CFA-8848316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36 binds IL1RL2 (Canis familiaris)
REACT:R-DRE-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Danio rerio)
RHEA:36851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA
RHEA:46907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) <=> a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)
REACT:R-CFA-6808487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
RHEA:52890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + nitrosobenzene => N-phenylhydroxylamine + NADP(+)
RHEA:44155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-phosphate + H2O <=> myo-inositol + phosphate
REACT:R-BTA-427528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Bos taurus)
REACT:R-HSA-374675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 dimer binds Ankyrin (Homo sapiens)
GO:0018606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzenesulfonate dioxygenase activity
GO:0018606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzenesulphonate dioxygenase activity
GO:0005362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Homo sapiens)
GO:0005362	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	low-affinity glucose-sodium cotransporter activity
GO:0005362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity glucose:sodium symporter activity
REACT:R-BTA-5660660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p300 acetylates RELA subunit (Bos taurus)
RHEA:68985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine
RHEA:29816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-proline(out) => ADP + H(+) + L-proline(in) + phosphate
RHEA:56436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-CFA-400509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Canis familiaris)
RHEA:33541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + ergosterol + H(+) => ergosteryl ester + H2O
RHEA:51414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2
RHEA:20537	skos:prefLabel	"[acyl-carrier-protein] phosphodiesterase"
RHEA:20537	skos:altLabel	"ACP hydrolyase"
RHEA:20537	skos:altLabel	"[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase"
RHEA:20537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[acyl-carrier-protein] phosphodiesterase"
RHEA:20537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + holo-[ACP] = (R)-4'-phosphopantetheine + apo-[ACP] + H(+)
RHEA:20537	skos:altLabel	"ACP phosphodiesterase"
RHEA:62145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + dGTP => 2 dGDP
GO:0004490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylglutaconyl-CoA hydratase activity
GO:0004490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)
GO:0004490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylglutaconase activity
GO:0004490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylglutaconyl coenzyme A hydratase activity
GO:0004490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity
GO:0004490	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methylglutaconyl CoA hydratase activity
REACT:R-DME-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Drosophila melanogaster)
REACT:R-CEL-5694417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Caenorhabditis elegans)
REACT:R-HSA-2514772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Homo sapiens)
REACT:R-MMU-420489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parathyroid hormone receptor can bind parathyroid hormone (Mus musculus)
RHEA:15881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]
REACT:R-MMU-1667005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Mus musculus)
REACT:R-XTR-419426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cannabinoid receptors can bind cannabinoids (Xenopus tropicalis)
REACT:R-MMU-420584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin 3 trans heterodimer interaction (Mus musculus)
RHEA:64537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base
RHEA:54838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + pentyl acetate => H(+) + heptan-2-one + NADPH + O2
RHEA:29735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butane-1-sulfonate + FMNH2 + O2 = butanal + FMN + 2 H(+) + H2O + sulfite
REACT:R-SCE-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)
REACT:R-CFA-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Canis familiaris)
EC:3.6.1.42	skos:altLabel	"GDPase"
EC:3.6.1.42	skos:prefLabel	"guanosine-diphosphatase"
EC:3.6.1.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanosine-diphosphatase"
REACT:R-GGA-449077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-16 is secreted (Gallus gallus)
GO:0030987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high molecular weight kininogen receptor binding
RHEA:12562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydroquinone O-beta-D-glucopyranoside + UDP => hydroquinone + UDP-alpha-D-glucose
GO:0043811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate:acyl-[acyl carrier protein] acyltransferase activity
GO:0043811	skos:altLabel	"phosphate-acyl-ACP acyltransferase"
GO:0043811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]
GO:0043811	skos:altLabel	"acyl-ACP phosphotransacylase"
GO:0043811	skos:prefLabel	"phosphate acyltransferase"
GO:0043811	skos:altLabel	"acyl-[acyl-carrier-protein]--phosphate acyltransferase"
GO:0043811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphate acyltransferase"
RHEA:16592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + sucrose <=> 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2
REACT:R-SSC-3318486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Sus scrofa)
REACT:R-RNO-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Rattus norvegicus)
REACT:R-DRE-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Danio rerio)
REACT:R-DRE-6800315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 binds MST1R (Danio rerio)
REACT:R-SSC-8851954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)
REACT:R-CFA-5660665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 binds MALT (Canis familiaris)
RHEA:31860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => glutinol
REACT:R-RNO-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)
REACT:R-DME-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Drosophila melanogaster)
REACT:R-DRE-5634103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 dissociates from atRA:RAR:RXR (Danio rerio)
REACT:R-XTR-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Xenopus tropicalis)
RHEA:51404	skos:prefLabel	"L-arginine oxidase"
RHEA:51404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arginine oxidase"
RHEA:51404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine + O2 = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)
GO:0042134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-rRNA binding
GO:0042134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA primary transcript binding
REACT:R-RNO-8851899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Rattus norvegicus)
RHEA:54403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
REACT:R-BTA-5634100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 dissociates from RXRA:PPARD:atRA (Bos taurus)
GO:0047728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine:NAD+ 3-oxidoreductase activity
GO:0047728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine 3-dehydrogenase activity
RHEA:15115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholestane-3beta,5,6beta-triol => 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O
GO:0062204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-vitexifolin A synthase activity
GO:0062204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate
REACT:R-BTA-2129353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin associates with microfibrils (Bos taurus)
REACT:R-BTA-2029453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of VAV (Bos taurus)
RHEA:32590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)
RHEA:69592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + inosine = cytidine + IMP
REACT:R-MMU-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Mus musculus)
REACT:R-BTA-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Bos taurus)
REACT:R-SCE-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Saccharomyces cerevisiae)
RHEA:48280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 + UDP-alpha-D-galactose = ganglioside GM1 + H(+) + UDP
RHEA:36480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA
REACT:R-MMU-9035227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN2 binds CysS248-MPST (Mus musculus)
RHEA:68697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-MMU-3928595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ARP2/3 and G-actin (Mus musculus)
RHEA:61308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0004918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-8 receptor activity
GO:0004918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-8 receptor activity
GO:0004918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-8R
REACT:R-DRE-201515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK recruits PI3K (Danio rerio)
REACT:R-DRE-4570493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Danio rerio)
RHEA:35380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
RHEA:42679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + L-histidine + O2 <=> H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide
EC:2.5.1.136	skos:altLabel	"aromatic prenyltransferase"
EC:2.5.1.136	skos:prefLabel	"2-acylphloroglucinol 4-prenyltransferase"
EC:2.5.1.136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-acylphloroglucinol 4-prenyltransferase"
RHEA:39933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-BTA-382054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binds to extracellular matrix proteins (Bos taurus)
REACT:R-HSA-8874718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA binds alpha-TOH (Homo sapiens)
REACT:R-BTA-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Bos taurus)
REACT:R-DRE-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Danio rerio)
REACT:R-MMU-2201338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds TICAM1:activated TLR4 complex (Mus musculus)
REACT:R-GGA-433940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with bacterial LPS (Gallus gallus)
REACT:R-SPO-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Schizosaccharomyces pombe)
RHEA:19725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + UDP-alpha-D-galacturonate = CO2 + UDP-beta-L-arabinopyranose
RHEA:19725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-galacturonate decarboxylase"
RHEA:19725	skos:altLabel	"UDP-D-galacturonate carboxy-lyase"
RHEA:19725	skos:prefLabel	"UDP-galacturonate decarboxylase"
REACT:R-CFA-430190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds NCK (Canis familiaris)
REACT:R-SSC-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Sus scrofa)
REACT:R-MMU-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Mus musculus)
REACT:R-CFA-2993898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRK1/VRK2 phosphorylate BANF1 (Canis familiaris)
REACT:R-HSA-5632652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds CDON and PTCH (Homo sapiens)
RHEA:41699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate
RHEA:53469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DDI-8953946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Dictyostelium discoideum)
RHEA:25901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabino-hex-3-ulose 6-phosphate => beta-D-fructose 6-phosphate
REACT:R-MMU-1254386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 forms a complex with estrogen receptor ESR1 (Mus musculus)
REACT:R-SSC-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Sus scrofa)
REACT:R-HSA-167130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP (Homo sapiens)
RHEA:22181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-norreticuline + S-adenosyl-L-methionine => (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-5686398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPIDR binds BLM:TOP3A:RMI1:RMI2 (Sus scrofa)
EC:2.7.11.19	skos:altLabel	"PHK"
EC:2.7.11.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphorylase kinase"
EC:2.7.11.19	skos:altLabel	"phosphorylase kinase (phosphorylating)"
EC:2.7.11.19	skos:altLabel	"dephosphophosphorylase kinase"
EC:2.7.11.19	skos:altLabel	"phosphorylase B kinase"
EC:2.7.11.19	skos:altLabel	"phosphorylase b kinase"
EC:2.7.11.19	skos:prefLabel	"phosphorylase kinase"
EC:2.7.11.19	skos:altLabel	"glycogen phosphorylase kinase"
REACT:R-DRE-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Danio rerio)
RHEA:23259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine <=> adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate
RHEA:37625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-MMU-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Mus musculus)
REACT:R-XTR-5672957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates KSR1 (Xenopus tropicalis)
RHEA:43390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + phosphate => 1D-myo-inositol 3,4-bisphosphate + H2O
REACT:R-SSC-75126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Sus scrofa)
RHEA:41643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
REACT:R-BTA-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Bos taurus)
REACT:R-HSA-448678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTSG cleaves CASP1(1-404) (Homo sapiens)
RHEA:28084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)
REACT:R-BTA-163751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Bos taurus)
RHEA:32794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ectoine(in) <=> L-ectoine(out)
REACT:R-BTA-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Bos taurus)
REACT:R-SCE-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Saccharomyces cerevisiae)
RHEA:32582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (1R,5R)-beta-pinene + diphosphate
REACT:R-DRE-9006844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21:IL21R:JAK1 binds IL2RG:JAK3 (Danio rerio)
REACT:R-MMU-5682588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 binds phosphorylated MDC1 at DNA DSBs (Mus musculus)
RHEA:66669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0005217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular ligand-gated ion channel activity
REACT:R-DME-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Drosophila melanogaster)
RHEA:31226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-beta-D-glucosyl-2-hydroxycinnamate + H2O <=> beta-D-glucose + cis-2-coumarate
RHEA:34602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine + NADP(+) <=> 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH
REACT:R-SSC-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Sus scrofa)
REACT:R-XTR-196350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Xenopus tropicalis)
REACT:R-HSA-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Homo sapiens)
REACT:R-BTA-164834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enzyme-bound ATP is released (Bos taurus)
REACT:R-DME-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Drosophila melanogaster)
REACT:R-DRE-199202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphopantetheine conjugation of the ACP domain of FAS (Danio rerio)
REACT:R-MMU-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Mus musculus)
REACT:R-HSA-9710988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 M protein interacts with TBK1/IKBKE  (Homo sapiens)
RHEA:60213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate
REACT:R-DRE-8852337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds TP53 (Danio rerio)
REACT:R-CEL-2032775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD1 (Caenorhabditis elegans)
RHEA:44099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decan-1-ol + hexadecanoyl-CoA <=> CoA + decanyl hexadecanoate
RHEA:13850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose => D-ribulose
REACT:R-HSA-418172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB2 (Homo sapiens)
RHEA:17606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate
RHEA:48072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate
REACT:R-CFA-5696838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Canis familiaris)
RHEA:24490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9605063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FASN regulated by NR1H2 or NR1H3 (Homo sapiens)
GO:0033427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAA codon-amino acid adaptor activity
GO:0033427	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine tRNA
REACT:R-RNO-9793680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)
RHEA:45310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta-prostaglandin F2-ethanolamide + NADP(+) => H(+) + NADPH + prostaglandin D2-ethanolamide
REACT:R-MMU-5682629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Mus musculus)
RHEA:59396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine = D-leucine
RHEA:52518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10 => trans-4-hydroxy-L-proline + ubiquinone-10
GO:0047432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dialkylglycine decarboxylase (pyruvate) activity
GO:0047432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-dialkyl amino acid transaminase activity
GO:0047432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity
GO:0047432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,2-dialkylglycine carboxy-lyase (amino-transferring)
GO:0047432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dialkylamino-acid decarboxylase (pyruvate)
GO:0047432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine-alpha-ketobutyrate aminotransferase activity
GO:0047432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dialkyl amino acid (pyruvate) decarboxylase activity
GO:0047432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)
RHEA:37164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-MMU-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Mus musculus)
REACT:R-DRE-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Danio rerio)
RHEA:55983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated acyl-CoA + an acyl-CoA + H2O <=> an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)
RHEA:16030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-guanidinopropanoate + H2O => beta-alanine + urea
RHEA:51251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate
REACT:R-DDI-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Dictyostelium discoideum)
REACT:R-HSA-5218830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates PTK2-beta (Homo sapiens)
REACT:R-CFA-199093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXADR binds to AMICA1 (Canis familiaris)
REACT:R-MMU-8871226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA2 (Mus musculus)
REACT:R-XTR-8987014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Xenopus tropicalis)
REACT:R-DDI-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Dictyostelium discoideum)
REACT:R-XTR-379415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Xenopus tropicalis)
REACT:R-BTA-2404199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:IGF1R autophosphorylates (Bos taurus)
REACT:R-CEL-5661123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate Me2K5-histone H3 (Caenorhabditis elegans)
GO:0160002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose modification-dependent protein binding
REACT:R-DDI-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Dictyostelium discoideum)
REACT:R-HSA-2586555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 Autophosphorylates in Response to Leptin (Homo sapiens)
RHEA:51908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + H2O = dADP + H(+) + phosphate
RHEA:54388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
REACT:R-XTR-5651723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Xenopus tropicalis)
REACT:R-DRE-2129362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin microfibril assembly (Danio rerio)
REACT:R-DRE-5621363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Danio rerio)
REACT:R-HSA-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Homo sapiens)
REACT:R-CFA-199425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLPP dephosphorylates S473 in AKT (Canis familiaris)
GO:0008168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyltransferase activity
GO:0008168	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methylase
REACT:R-RNO-390909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds hist (Rattus norvegicus)
REACT:R-XTR-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Xenopus tropicalis)
RHEA:40634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trioctadecanoylglycerol <=> 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate
RHEA:22256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH
REACT:R-MMU-420233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VIP receptors bind VIP (Mus musculus)
REACT:R-MMU-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Mus musculus)
GO:0016316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity
GO:0016316	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol polyphosphate 4-phosphatase type II activity
GO:0016316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
RHEA:67642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dZDP => ATP + dZMP
REACT:R-DME-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Drosophila melanogaster)
REACT:R-SSC-5686704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates DCLRE1C (Sus scrofa)
REACT:R-DRE-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Danio rerio)
RHEA:18842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NADP(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADPH
RHEA:61467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in mRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:44273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-HSA-193774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)
RHEA:65628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine
REACT:R-SSC-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Sus scrofa)
RHEA:50999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine
RHEA:56669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
REACT:R-RNO-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Rattus norvegicus)
REACT:R-XTR-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)
RHEA:65416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP(in) + NAD(+)(out) = dGMP(out) + NAD(+)(in)
REACT:R-DRE-5686924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Danio rerio)
RHEA:67877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine => 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:44711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
RHEA:56304	skos:prefLabel	"rifampicin phosphotransferase"
RHEA:56304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rifampicin phosphotransferase"
RHEA:56304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + rifampicin = 21-phosphorifampicin + AMP + 2 H(+) + phosphate
REACT:R-SSC-5620975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PIPs (Sus scrofa)
RHEA:59843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + syringate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate
REACT:R-CFA-8856189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF8 binds TNFRSF8 (Canis familiaris)
RHEA:58798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 7-O-beta-D-glucoside + malonyl-CoA
REACT:R-DRE-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Danio rerio)
RHEA:68411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-iso(homo)3citrate + NAD(+) <=> 2-oxosuberate + CO2 + NADH
RHEA:13028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]
RHEA:66426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + leukotriene B4(out) + phosphate => ATP + H2O + leukotriene B4(in)
GO:0052921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone-cyanohydrin acetone-lyase (cyanide-forming) activity
REACT:R-CFA-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Canis familiaris)
REACT:R-DME-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Drosophila melanogaster)
REACT:R-SSC-429786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Sus scrofa)
REACT:R-RNO-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Rattus norvegicus)
REACT:R-SSC-6786012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Sus scrofa)
REACT:R-CFA-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Canis familiaris)
RHEA:58393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Rattus norvegicus)
REACT:R-DRE-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Danio rerio)
REACT:R-BTA-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Bos taurus)
REACT:R-CFA-3204318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Canis familiaris)
REACT:R-MMU-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Mus musculus)
EC:3.2.1.135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neopullulanase"
EC:3.2.1.135	skos:prefLabel	"neopullulanase"
REACT:R-MMU-8849348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Mus musculus)
REACT:R-CFA-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Canis familiaris)
REACT:R-HSA-2429719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCPH1 sequesters condensin II (Homo sapiens)
RHEA:45753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-decenoyl-CoA => (2E)-decenoyl-CoA
REACT:R-HSA-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Homo sapiens)
GO:0034281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokaurene synthase activity
REACT:R-CFA-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Canis familiaris)
RHEA:33893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chanoclavine-I aldehyde + H(+) + NADH => chanoclavine-I + NAD(+)
RHEA:48931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide
REACT:R-CFA-8870346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Canis familiaris)
REACT:R-DRE-6805285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates TP53 (Danio rerio)
RHEA:19767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanal + H2O => glycerol
RHEA:55925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole + O2 + reduced [NADPH--hemoprotein reductase] => albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-202939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of E-Cadherin (Danio rerio)
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine-5'-phosphate carboxy-lyase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OMP decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine phosphate decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotic decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine monophosphate decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ODCase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidylic decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine-5'-monophosphate decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine 5'-phosphate decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UMP synthase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidylic acid decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OMP-DC
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotate decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OMPdcase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orotidine-5'-phosphate decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotodylate decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine-5'-phosphate carboxy-lyase (UMP-forming)
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotate monophosphate decarboxylase activity
GO:0004590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine 5'-monophosphate synthase activity
RHEA:55530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-tyrosine + O2
RHEA:52775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate
REACT:R-XTR-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Xenopus tropicalis)
RHEA:22860	skos:prefLabel	"nicotinate-nucleotide adenylyltransferase"
RHEA:22860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate
RHEA:22860	skos:altLabel	"deamido-NAD(+) pyrophosphorylase"
RHEA:22860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinate-nucleotide adenylyltransferase"
RHEA:22860	skos:altLabel	"Deamido-NAD(+) diphosphorylase"
REACT:R-BTA-3769447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex deacetylate histones (Bos taurus)
RHEA:51638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + selenate => a quinone + H2O + selenite
REACT:R-DME-975119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Drosophila melanogaster)
REACT:R-BTA-141422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 converted  to an inhibitory state via interaction with Mad1 (Bos taurus)
RHEA:42180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-GGA-5662620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds cadmium (Gallus gallus)
REACT:R-HSA-9693589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 dsRNA intermediates bind DDX58 (Homo sapiens)
REACT:R-BTA-8852809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPN, CPB2 cleave C3a, C5a (Bos taurus)
REACT:R-GGA-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Gallus gallus)
REACT:R-SSC-9724685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds omalizumab (Sus scrofa)
GO:0046507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-sulfoquinovose synthase activity
GO:0046507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDPsulfoquinovose synthase activity
GO:0046507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity
GO:0046507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDPsulphoquinovose synthase activity
GO:0046507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite:UDP-glucose sulfotransferase activity
REACT:R-XTR-2161282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastic fibres bind associated proteins (Xenopus tropicalis)
RHEA:40647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-BTA-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Bos taurus)
RHEA:62439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lyxonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O
REACT:R-HSA-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Homo sapiens)
REACT:R-BTA-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Bos taurus)
RHEA:58102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoate + glycerol + H(+) => 1-(15Z-tetracosenoyl)-glycerol + H2O
RHEA:45602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate + H(+) => D-galactaro-1,4-lactone
REACT:R-CEL-9625487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates downstream of EGFR (Caenorhabditis elegans)
REACT:R-HSA-77614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR1) (Homo sapiens)
RHEA:14550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + formate + H(+)
RHEA:64391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 A + sn-3-O-phytanylglycerol 1-phosphate <=> 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
REACT:R-MMU-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Mus musculus)
RHEA:57364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADH = (6S)-NADHX
RHEA:13149	skos:prefLabel	"NADPH dehydrogenase"
RHEA:13149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H(+) + NADPH = AH2 + NADP(+)
RHEA:13149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADPH dehydrogenase"
RHEA:13149	skos:altLabel	"NADPH diaphorase"
RHEA:71626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(out) + phosphate(in) <=> malonate(in) + phosphate(out)
GO:0047107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GBAL dehydrogenase activity
GO:0047107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-guanidinobutyraldehyde dehydrogenase activity
GO:0047107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-guanidinobutanal:NAD+ 1-oxidoreductase activity
GO:0047107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-guanidinobutyraldehyde dehydrogenase activity
GO:0047107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-guanidinobutyraldehyde dehydrogenase activity
RHEA:56524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydro-heme d1 = AH2 + heme d1
REACT:R-MMU-1433506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APS (Mus musculus)
RHEA:13256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)
GO:0004042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AGAS
GO:0004042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglutamate acetylglutamate synthetase activity
GO:0004042	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	amino-acid N-acetyltransferase activity
GO:0004042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA:L-glutamate N-acetyltransferase activity
GO:0004042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amino acid acetyltransferase activity
GO:0004042	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N-acetylglutamate synthase activity
REACT:R-SSC-380508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NuMA to the centrosomes (Sus scrofa)
REACT:R-CFA-5359451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from SAM to NAM to form MNA (Canis familiaris)
REACT:R-DME-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Drosophila melanogaster)
RHEA:64290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-9680812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp7 binds nsp8 (Homo sapiens)
REACT:R-CEL-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Caenorhabditis elegans)
RHEA:17917	skos:prefLabel	"glutathione gamma-glutamylcysteinyltransferase"
RHEA:17917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione gamma-glutamylcysteinyltransferase"
RHEA:17917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine
RHEA:17917	skos:altLabel	"phytochelatin synthase"
REACT:R-CFA-5693583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDC1 associates with gamma-H2AFX at nuclear foci (Canis familiaris)
RHEA:68864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isomaltose = alpha-D-glucose + D-glucose
GO:0051378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serotonin binding
GO:0051378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine binding
REACT:R-GGA-1358801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds RNF41 ubiquitin ligase (Gallus gallus)
REACT:R-HSA-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Homo sapiens)
REACT:R-CFA-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Canis familiaris)
RHEA:31478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol B + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP
RHEA:35090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N'-monoacetylchitobiose-6'-phosphate <=> D-glucosamine + N-acetyl-D-glucosamine 6-phosphate
REACT:R-DRE-1474197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP1,3,8,13,PRSS2 (Danio rerio)
RHEA:60950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine => (S)-eriodictyol + S-adenosyl-L-methionine
RHEA:12211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferyl acetate + H2O <=> 4-methylumbelliferone + acetate + H(+)
REACT:R-CEL-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Caenorhabditis elegans)
GO:0086061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential
GO:0086061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in bundle of His cell action potential
REACT:R-SSC-751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gz complex dissociates (Sus scrofa)
RHEA:29311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + O2 + sulfoacetate = FMN + glyoxylate + 2 H(+) + H2O + sulfite
REACT:R-MMU-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Mus musculus)
RHEA:10676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O
GO:0003723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly-A RNA binding
GO:0003723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(A)-RNA binding
GO:0003723	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	base pairing with RNA
GO:0003723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exportin-5 recognizes 3' overhang of pre-miRNA  (Homo sapiens)
GO:0003723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(A) RNA binding
GO:0003723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA binding
REACT:R-MMU-4551679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO2 (Mus musculus)
RHEA:58267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside
RHEA:11790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + NH4(+) + oxaloacetate => H2O + L-aspartate + NAD(+)
REACT:R-MMU-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Mus musculus)
RHEA:55958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(9Z)-octadecenoate + A + H2O => (9Z)-octadecenoate + AH2 + O2
REACT:R-XTR-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Xenopus tropicalis)
REACT:R-XTR-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Xenopus tropicalis)
RHEA:50114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octadecanoyl-taurine => octadecanoyl-CoA + taurine
REACT:R-HSA-194311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Homo sapiens)
REACT:R-HSA-5621370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Homo sapiens)
REACT:R-DRE-5692283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)
REACT:R-DRE-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Danio rerio)
RHEA:58100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(15Z-tetracosenoyl)-glycerol + H2O = (15Z)-tetracosenoate + glycerol + H(+)
RHEA:68686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate) => 3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate)
REACT:R-GGA-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Gallus gallus)
RHEA:39283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid(out) = a long-chain fatty acid(in)
REACT:R-RNO-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Rattus norvegicus)
REACT:R-RNO-109470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Rattus norvegicus)
RHEA:34880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + methyl 3-cyano-2-phenylpropanoate => 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)
REACT:R-DME-5610732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI3 (Drosophila melanogaster)
RHEA:39164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-CoA + NADP(+)
REACT:R-RNO-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Rattus norvegicus)
RHEA:45670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+)
REACT:R-CEL-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Caenorhabditis elegans)
RHEA:47866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioctanoylglycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O
REACT:R-DME-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Drosophila melanogaster)
RHEA:20690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorogenate + H2O => (E)-caffeate + H(+) + L-quinate
RHEA:42419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)
REACT:R-RNO-1112510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6ST is tyrosine phosphorylated (Rattus norvegicus)
REACT:R-CFA-5617138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Canis familiaris)
REACT:R-DME-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Drosophila melanogaster)
REACT:R-SCE-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)
RHEA:57266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP
REACT:R-DME-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Drosophila melanogaster)
REACT:R-MMU-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Mus musculus)
REACT:R-GGA-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)
REACT:R-BTA-170076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Bos taurus)
REACT:R-CFA-1861789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Canis familiaris)
RHEA:45075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9759186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2- dependent NQO1 gene expression (Homo sapiens)
REACT:R-SPO-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Schizosaccharomyces pombe)
EC:1.1.1.419	skos:prefLabel	"nepetalactol dehydrogenase"
EC:1.1.1.419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nepetalactol dehydrogenase"
RHEA:43879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA <=> 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate
RHEA:71717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-leucyl-L-leucine(in) => H(+)(out) + L-leucyl-L-leucine(out)
RHEA:68182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty acid + CoA + H(+) => a short-chain fatty acyl-CoA + H2O
RHEA:20653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23,24-dihydrocucurbitacin B + NAD(+) = cucurbitacin B + H(+) + NADH
REACT:R-SSC-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Sus scrofa)
RHEA:41767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) <=> CMP + ganglioside GT3 (d18:1(4E)) + H(+)
REACT:R-HSA-1222399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iron is reduced and separates from mycobactin (Homo sapiens)
REACT:R-CFA-8874202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the cytosol to the nucleus (Canis familiaris)
REACT:R-GGA-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Gallus gallus)
RHEA:67218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA
RHEA:65684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine
GO:0070626	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succino AMP-lyase activity
GO:0070626	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	adenylosuccinase activity
GO:0070626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
GO:0070626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity
GO:0070626	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	adenylosuccinate lyase activity
GO:0070626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SAICAR-lyase (fumarate forming) activity
RHEA:30718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol <=> (S)-linalool
RHEA:23733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-diphosphomevalonate + ATP => ADP + CO2 + isopentenyl diphosphate + phosphate
REACT:R-CFA-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Canis familiaris)
REACT:R-SSC-4085021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Sus scrofa)
REACT:R-CFA-6800298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF dimer binds MET (Canis familiaris)
REACT:R-HSA-5336421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DT fragment A ADP-ribosylates target cell EEF (Homo sapiens)
RHEA:28814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxo-L-gulonate(in) + Na(+)(in) <=> 2,3-dioxo-L-gulonate(out) + Na(+)(out)
REACT:R-SPO-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Schizosaccharomyces pombe)
REACT:R-HSA-8867098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycophorins bind plasmodium falciparum Ags (Homo sapiens)
GO:0000834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol heptakisphosphate 6-kinase activity
RHEA:53286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-scyllo-inosose + H(+) + NADH => NAD(+) + scyllo-inosose
REACT:R-HSA-6782820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates SUDS3 (Homo sapiens)
REACT:R-HSA-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Homo sapiens)
REACT:R-RNO-2160874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses (HA)50 (Rattus norvegicus)
REACT:R-DRE-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Danio rerio)
RHEA:11137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)
RHEA:13025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]
REACT:R-XTR-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Xenopus tropicalis)
GO:0038121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CCL21 receptor activity
GO:0038121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-C motif chemokine 21 receptor activity
REACT:R-HSA-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Homo sapiens)
RHEA:44054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-hexadecanoyl-alpha,alpha-trehalose + CoA => alpha,alpha-trehalose + hexadecanoyl-CoA
RHEA:50862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2
RHEA:34779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH
RHEA:35081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	doxorubicin(out) => doxorubicin(in)
RHEA:33324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
RHEA:14539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+) => 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O
REACT:R-MMU-6797810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAPL1 (Mus musculus)
EC:1.1.1.92	skos:prefLabel	"oxaloglycolate reductase (decarboxylating)"
EC:1.1.1.92	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxaloglycolate reductase (decarboxylating)"
REACT:R-MMU-9759206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Mus musculus)
RHEA:13312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + vanillin <=> 2 H(+) + NADH + vanillate
RHEA:71174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-cysteine(out) + Na(+)(out) <=> H(+)(out) + L-cysteine(in) + Na(+)(in)
REACT:R-RNO-8956099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Rattus norvegicus)
REACT:R-BTA-1295621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)
REACT:R-SSC-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Sus scrofa)
REACT:R-BTA-2684507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2, 4, (3) bind FGF2 (Bos taurus)
REACT:R-XTR-917891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Xenopus tropicalis)
REACT:R-BTA-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Bos taurus)
RHEA:31233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanoate + 2 H(+) + NADH => 4-acetamidobutanal + H2O + NAD(+)
GO:0030733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acid methyltransferase activity
GO:0030733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid O-methyltransferase activity
GO:0030733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity
GO:0030733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acid O-methyltransferase activity
GO:0001792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polymeric immunoglobulin receptor activity
RHEA:28915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) + H(+)(in) = 4-aminobutanoate(out) + H(+)(out)
REACT:R-XTR-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Xenopus tropicalis)
REACT:R-RNO-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)
REACT:R-SSC-5649723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Sus scrofa)
REACT:R-CEL-8939688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) complex binds RUNX2 (Caenorhabditis elegans)
RHEA:59571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + ATP + L-histidine <=> ADP + H(+) + L-homocarnosine + phosphate
REACT:R-CFA-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Canis familiaris)
RHEA:55598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NORint + H(+) + UDP => globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine
RHEA:44797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-13 + S-adenosyl-L-methionine => H(+) + menaquinol-13 + S-adenosyl-L-homocysteine
RHEA:42308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:60001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylphosphonate + O2 => formate + 2 H(+) + phosphate
REACT:R-PFA-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Plasmodium falciparum)
RHEA:32228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-NADPHX => (6S)-NADPHX
RHEA:19395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + L-alanine => L-lysine + pyruvate
REACT:R-GGA-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Gallus gallus)
REACT:R-BTA-165692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of 4E-BP1 by activated mTORC1 (Bos taurus)
RHEA:68025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + presqualene monophosphate => phosphate + presqualene alcohol
RHEA:52704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UMP = D-ribose 5-phosphate + uracil
RHEA:67326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine => acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine
RHEA:62474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:39721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate
EC:3.4.21.38	skos:prefLabel	"coagulation factor XIIa"
EC:3.4.21.38	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coagulation factor XIIa"
EC:3.4.21.38	skos:altLabel	"Hageman factor"
REACT:R-CFA-209125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Canis familiaris)
RHEA:66368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methyl-3,7-dioxodecanedioyl-CoA + CoA = 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA
RHEA:12470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-desgluco-avenacoside A + D-glucose => avenacoside A + H2O
REACT:R-HSA-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Homo sapiens)
RHEA:29883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-ornithine(out) = ADP + H(+) + L-ornithine(in) + phosphate
RHEA:44442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + glycerol => a 1,3-diacylglycerol + a 1-acylglycerol
REACT:R-HSA-437139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT6 transports zinc into the golgi apparatus (Homo sapiens)
RHEA:24786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)
RHEA:58547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-tetradecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine
GO:0003785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin monomer binding
GO:0003785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G actin binding
REACT:R-DDI-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Dictyostelium discoideum)
RHEA:59169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate => AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]
RHEA:61391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin(in) + H2O <=> ADP + biotin(out) + H(+) + phosphate
EC:3.4.21.3	skos:prefLabel	"metridin"
EC:3.4.21.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"metridin"
EC:3.4.21.3	skos:altLabel	"Metridium proteinase A"
EC:3.4.21.3	skos:altLabel	"sea anemone protease A"
REACT:R-BTA-205321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of KIT and sSCF (Bos taurus)
RHEA:25832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-chiro-inositol 1-dehydrogenase"
RHEA:25832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine
RHEA:25832	skos:altLabel	"DCI 1-dehydrogenase"
RHEA:25832	skos:prefLabel	"D-chiro-inositol 1-dehydrogenase"
REACT:R-MMU-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)
RHEA:52841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vanillate => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP
GO:1990309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type-II dockerin domain binding
RHEA:17323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine => L-tryptophan + S-adenosyl-L-methionine
GO:0102772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid long-chain base 4-hydroxylase activity
REACT:R-GGA-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Gallus gallus)
RHEA:17839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-D-arabinitol + phosphate => 2-carboxy-D-arabinitol 1-phosphate + H2O
RHEA:29405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-8 + A + H2O => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2
REACT:R-SSC-159728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-prothrombin to prothrombin (Sus scrofa)
RHEA:41819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GD2 (d18:1(4E)) + H(+) + UDP
REACT:R-MTU-937192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine from cystathionine and vice versa (Mycobacterium tuberculosis)
REACT:R-SPO-73920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Schizosaccharomyces pombe)
GO:0031857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 parathyroid hormone receptor binding
GO:0031857	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 parathyroid hormone receptor ligand
REACT:R-DME-2562594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated OPTN translocates to the nucleus (Drosophila melanogaster)
RHEA:10316	skos:altLabel	"thymine,2-oxoglutarate dioxygenase"
RHEA:10316	skos:prefLabel	"thymine dioxygenase"
RHEA:10316	skos:altLabel	"thymine 7-hydroxylase"
RHEA:10316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thymine dioxygenase"
RHEA:10316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + thymine = 5-hydroxymethyluracil + CO2 + succinate
RHEA:13665	skos:prefLabel	"guanylate cyclase"
RHEA:13665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanylate cyclase"
RHEA:13665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP = 3',5'-cyclic GMP + diphosphate
RHEA:13665	skos:altLabel	"guanylyl cyclase"
RHEA:13665	skos:altLabel	"guanyl cyclase"
GO:0030674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-macromolecule adaptor activity
GO:0030674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein-protein adaptor
GO:0030674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein binding, bridging
GO:0030674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein recruiting activity
GO:0004361	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaryl coenzyme A dehydrogenase activity
GO:0004361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA dehydrogenase activity
REACT:R-DRE-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Danio rerio)
REACT:R-XTR-189384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLVRA:Zn2+, BLVRB reduce BV to BIL (Xenopus tropicalis)
REACT:R-DME-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Drosophila melanogaster)
REACT:R-GGA-8852306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Gallus gallus)
REACT:R-SCE-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Saccharomyces cerevisiae)
REACT:R-SSC-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Sus scrofa)
REACT:R-XTR-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Xenopus tropicalis)
RHEA:62612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine
RHEA:59609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-L-lysine + H2O => beta-alanine + L-lysine
REACT:R-GGA-9032751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Gallus gallus)
RHEA:52293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:39705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-eicosenoyl-CoA + NADP(+) => (2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH
REACT:R-DRE-6794346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind NLGNs (Danio rerio)
RHEA:30824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
REACT:R-HSA-3797226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease) (Homo sapiens)
RHEA:53376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(16) in tRNA + NADP(+) = H(+) + NADPH + uridine(16) in tRNA
RHEA:57859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + 2-oxoglutarate + O2 <=> (E)-6-hydroxyferuloyl-CoA + CO2 + succinate
GO:0043871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AmaB
GO:0043871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PIPOX
GO:0043871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta1-piperideine-6-carboxylate dehydrogenase activity
RHEA:55676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + NH4(+) = (2S)-2-amino-4-deoxychorismate + H2O
REACT:R-CFA-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Canis familiaris)
RHEA:68301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + tetradecanoyl-CoA => CoA + O-tetradecanoyl-L-seryl-[protein]
RHEA:32113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-resveratrol
RHEA:37102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP
REACT:R-CFA-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Canis familiaris)
REACT:R-SCE-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Saccharomyces cerevisiae)
REACT:R-BTA-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Bos taurus)
RHEA:57093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + S-(methylsulfanyl)glutathione => A + glutathione + methanethiol
RHEA:60616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine = ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate
REACT:R-DRE-375384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bombesin-like receptors bind bombesin homologues (Danio rerio)
RHEA:55251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-2426163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the CYP51A1 promoter (Homo sapiens)
REACT:R-MMU-5333051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA1 binds HSF1 (Mus musculus)
REACT:R-SSC-1678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses CS/HS precursor (Sus scrofa)
REACT:R-BTA-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Bos taurus)
RHEA:33520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine => (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-DRE-5654701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
REACT:R-CFA-9678737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR1:TYK2 binds TYK2 inhibitors (Canis familiaris)
REACT:R-BTA-166220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion diffuses laterally to UCP (Bos taurus)
REACT:R-HSA-8870346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Homo sapiens)
RHEA:23195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-HSA-8851038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 binds prenylated phosphoantigens (Homo sapiens)
GO:0140562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-domain serine xylosyltransferase activity
REACT:R-BTA-9629149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves thymine glycol from damaged DNA (Bos taurus)
REACT:R-HSA-9710468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME variant does not bind PIPs (Homo sapiens)
RHEA:29489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-muurola-3,5-diene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:46759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-216283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDX binds to and ubiquitinates CI (Drosophila melanogaster)
REACT:R-BTA-2168887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Albumin to Hemopexin (Bos taurus)
RHEA:59816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA
RHEA:35209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + IMP + phosphate => H2O + IDP
RHEA:32184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 => cholest-5-en-3-one + H2O2
REACT:R-MMU-8852337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds TP53 (Mus musculus)
GO:0016505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidase activator activity involved in apoptotic process
GO:0016505	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	apoptotic protease activator activity
REACT:R-DRE-5607756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomer autoubiquitinates (Danio rerio)
RHEA:51368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylglycine
REACT:R-BTA-8851988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A2 binds T cell surface (Bos taurus)
RHEA:37963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NAD(+) = D-galactose + H(+) + NADH
RHEA:37963	skos:prefLabel	"aldose reductase"
RHEA:37963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldose reductase"
RHEA:37963	skos:altLabel	"polyol dehydrogenase (NADP(+))"
RHEA:37963	skos:altLabel	"aldehyde reductase"
RHEA:36632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 1,5-bisphosphate + O2 => (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)
RHEA:64050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(13Z-docosenoyl)-sphinganine => (13Z)-docosenoyl-CoA + sphinganine
RHEA:35709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-versiconol acetate + H2O + NADP(+) => (2S)-versicolorone + H(+) + NADPH + O2
RHEA:41738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) => 3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
REACT:R-DRE-6800798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome binds CASP2 (Danio rerio)
REACT:R-HSA-5610717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI2 (Homo sapiens)
REACT:R-BTA-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Bos taurus)
RHEA:11639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADPH
REACT:R-GGA-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Gallus gallus)
REACT:R-RNO-9018785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds GTP (Rattus norvegicus)
REACT:R-RNO-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Rattus norvegicus)
REACT:R-HSA-6802837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss-of-function NF1 variants don't stimulate RAS GTPase activity (Homo sapiens)
RHEA:53067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxyestrone + UDP-alpha-D-glucuronate <=> 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-DME-209200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex (Drosophila melanogaster)
GO:0047482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine-adding enzyme activity
GO:0047482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity
GO:0047482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)
GO:0047482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MurE synthetase activity
GO:0047482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity
GO:0047482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity
GO:0047482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity
RHEA:36028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + propanal => H(+) + NADH + propanoyl-CoA
REACT:R-RNO-5654167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds PLCG1 (Rattus norvegicus)
REACT:R-SSC-163096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Telomerase RNP to the Telomeric Chromosome End (Sus scrofa)
REACT:R-GGA-2424252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds collagen, fibronectin, aggrecan and matrilins (Gallus gallus)
GO:0033822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity
GO:0033822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity
GO:0033822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosyl-DNA beta-glucosyltransferase activity
GO:0033822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T6-beta-glucosyl transferase activity
GO:0033822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity
GO:0033822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T6-glucosyl-HMC-beta-glucosyl transferase activity
REACT:R-CFA-198609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates TSC2, inhibiting it (Canis familiaris)
RHEA:27511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine => dehydro coenzyme F420-0 + GMP + H(+)
REACT:R-HSA-5610767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Homo sapiens)
REACT:R-RNO-209772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to triiodothyronine (Rattus norvegicus)
REACT:R-SSC-6805035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds STK11 and NUAK1 (Sus scrofa)
RHEA:45150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-(methylsulfanyl)acryloyl-CoA + H2O
REACT:R-DRE-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Danio rerio)
REACT:R-GGA-166726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MASPs (Gallus gallus)
REACT:R-SSC-3134954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX9 binds DNA (Sus scrofa)
RHEA:31320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + UDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP
REACT:R-RNO-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Rattus norvegicus)
RHEA:34135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabigerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2
RHEA:69529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + H2O + 2 L-glutamine => 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)
RHEA:65639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-(4E,8E)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine
REACT:R-RNO-975185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)
REACT:R-BTA-6809521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPIF binds bacteria (Bos taurus)
REACT:R-DME-170026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protons are translocated from the intermembrane space to the matrix (Drosophila melanogaster)
RHEA:54854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + propyl butanoate => H(+) + heptan-4-one + NADPH + O2
REACT:R-XTR-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Xenopus tropicalis)
RHEA:65539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,7-trimethylurate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theacrine
GO:0035256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled glutamate receptor binding
GO:0035256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metabotropic glutamate receptor binding
GO:0035256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled glutamate receptor binding
REACT:R-RNO-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)
REACT:R-XTR-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Xenopus tropicalis)
RHEA:19215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-L-cysteine-S-conjugate + CoA + H(+) => acetyl-CoA + an S-substituted L-cysteine
REACT:R-HSA-9009526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Homo sapiens)
REACT:R-DME-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Drosophila melanogaster)
REACT:R-GGA-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Gallus gallus)
RHEA:27616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate => (2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate
REACT:R-BTA-5686625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAIR1 binds collagen (Bos taurus)
RHEA:71516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine(out) => hypoxanthine(in)
REACT:R-BTA-428205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [Golgi] (Bos taurus)
EC:1.5.1.34	skos:altLabel	"DHPR"
EC:1.5.1.34	skos:altLabel	"dihydropteridine reductase (NADH)"
EC:1.5.1.34	skos:altLabel	"6,7-dihydropteridine:NAD(P)H oxidoreductase"
EC:1.5.1.34	skos:altLabel	"NADPH-specific dihydropteridine reductase"
EC:1.5.1.34	skos:altLabel	"NADH-dihydropteridine reductase"
EC:1.5.1.34	skos:altLabel	"NAD(P)H2:6,7-dihydropteridine oxidoreductase"
EC:1.5.1.34	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6,7-dihydropteridine reductase"
EC:1.5.1.34	skos:altLabel	"NADPH-dihydropteridine reductase"
EC:1.5.1.34	skos:altLabel	"dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase"
EC:1.5.1.34	skos:altLabel	"dihydropteridine reductase"
EC:1.5.1.34	skos:prefLabel	"6,7-dihydropteridine reductase"
REACT:R-BTA-879594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO4C1 mediates the transport of digoxin (Bos taurus)
GO:0003986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A deacylase activity
GO:0003986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA thiol esterase activity
GO:0003986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA acylase activity
GO:0003986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA hydrolase activity
GO:0003986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A acylase activity
GO:0003986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A hydrolase activity
GO:0003986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA deacylase activity
REACT:R-RNO-6783530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gp130:JAKs bind CNTFR (Rattus norvegicus)
RHEA:40884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2
RHEA:43248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate
RHEA:35416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose => an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP
REACT:R-GGA-5625426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde IFT (Gallus gallus)
RHEA:19076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[I-kappa-B protein] <=> ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]
GO:0017050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythro-sphingosine kinase activity
GO:0017050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine kinase activity
GO:0023029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class Ib protein binding
REACT:R-HSA-8877153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 binds PC (Homo sapiens)
REACT:R-XTR-205289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of KIT (Xenopus tropicalis)
RHEA:56243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]
GO:0052775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-(1->3)-alpha-L-rhamnosidase activity
GO:0052775	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endorhamnosidase activity
GO:0052775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-1,3-alpha-L-rhamnosidase activity
GO:0052775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-(1,3)-alpha-L-rhamnosidase activity
REACT:R-CFA-2404200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2 binds IGF1R (Canis familiaris)
REACT:R-MMU-2424482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p85 regulatory unit of PI3K binds p-6Y-SYK (Mus musculus)
REACT:R-XTR-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Xenopus tropicalis)
GO:0008688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)
GO:0008688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)propionate hydroxylase activity
RHEA:28209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + ATP <=> ADP + dUMP + H(+)
RHEA:58407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + NADP(+) <=> H(+) + hexanal + NADPH
RHEA:66559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + L-glutaminyl-[protein] <=> 5-dopaminyl-L-glutamyl-[protein] + NH4(+)
RHEA:33540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosteryl ester + H2O => a carboxylate + ergosterol + H(+)
REACT:R-SCE-6811412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer to the Golgi (Saccharomyces cerevisiae)
RHEA:45683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)
REACT:R-GGA-353301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Pol kappa and REV1 complex to the lesion on the template DNA strand (Gallus gallus)
RHEA:14242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4-hydroxybenzaldehyde + acetyl-CoA => 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)
RHEA:13386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoate + H(+) => 2-undecanone + CO2
RHEA:69121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-phenylalanine => 3-phenylpyruvate + glycine
REACT:R-BTA-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Bos taurus)
RHEA:48357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
RHEA:66457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-2187388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Homo sapiens)
RHEA:61190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose
RHEA:64776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanylpentan-1-ol-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol
REACT:R-SSC-5694417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Sus scrofa)
REACT:R-BTA-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Bos taurus)
REACT:R-HSA-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Homo sapiens)
REACT:R-MMU-166220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion diffuses laterally to UCP (Mus musculus)
RHEA:72202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + 2 H(+)(out) <=> Ca(2+)(out) + 2 H(+)(in)
REACT:R-SPO-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Schizosaccharomyces pombe)
RHEA:51228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate = 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Canis familiaris)
RHEA:62468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + ATP + H(+) = 3,4-dihydroxybenzoyl-5'-AMP + diphosphate
GO:0005164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tumor necrosis factor receptor binding
GO:0005164	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tumor necrosis factor receptor ligand
GO:0005164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF receptor binding
GO:0005164	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tumor necrosis factor
REACT:R-SPO-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)
REACT:R-BTA-2213017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF3 (Bos taurus)
REACT:R-XTR-2574840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA facilitates AURKA autophosphorylation (Xenopus tropicalis)
REACT:R-CFA-6801808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A,REG3G binds bacterial peptidoglycan (Canis familiaris)
RHEA:53705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O => H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine
GO:0034022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(hydroxyamino)phenol hydroxymutase activity
GO:0034022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxylaminophenol mutase activity
GO:0034022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3HAP mutase activity
GO:0034022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(hydroxyamino)phenol mutase activity
RHEA:62329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2
REACT:R-SCE-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Saccharomyces cerevisiae)
REACT:R-BTA-374758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Somatostatin receptors bind somatostatin and cortistatin (Bos taurus)
RHEA:70230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA <=> (E)-2-benzylidenesuccinyl-CoA + H2O
RHEA:11615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH + NH4(+)
RHEA:29086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + ubiquinone-8 <=> oxaloacetate + ubiquinol-8
RHEA:52010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA
REACT:R-BTA-430076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds 14-3-3-zeta (Bos taurus)
REACT:R-GGA-5666070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Gallus gallus)
REACT:R-HSA-9717382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)
REACT:R-PFA-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Plasmodium falciparum)
GO:0050683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AF-1 domain binding
REACT:R-BTA-195251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the destruction complex (Bos taurus)
REACT:R-CFA-432096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
RHEA:16481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotianamine synthase"
RHEA:16481	skos:prefLabel	"nicotianamine synthase"
RHEA:16481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine
REACT:R-HSA-5651773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds POLB at long-patch BER site (Homo sapiens)
REACT:R-BTA-417842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 receptor can bind to LPA (Bos taurus)
REACT:R-HSA-428296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF2BP1 binds specific RNAs (Homo sapiens)
REACT:R-XTR-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Xenopus tropicalis)
REACT:R-DME-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Drosophila melanogaster)
RHEA:62829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
RHEA:41955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
REACT:R-XTR-5687101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 phosphorylates FOXO3 (Xenopus tropicalis)
RHEA:46157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,9'-di-cis-phytofluene + a plastoquinone => 9,9',15-tri-cis-zeta-carotene + a plastoquinol
GO:0102241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasaponin III rhamnosyltransferase activity
RHEA:28667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydroxyacetone + NADH = (S)-propane-1,2-diol + NAD(+)
REACT:R-DDI-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Dictyostelium discoideum)
RHEA:56355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)
RHEA:56020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)
RHEA:60919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in mRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-77591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Mus musculus)
REACT:R-HSA-2581474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK1,4,7 phosphorylate MII to p-MII (Homo sapiens)
RHEA:58430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-2,4-hexadienal + H(+) + NADPH => (E,E)-2,4-hexadien-1-ol + NADP(+)
REACT:R-SPO-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Schizosaccharomyces pombe)
RHEA:68029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,8-dihydroxypurine + H2O + O2 => H2O2 + urate
REACT:R-XTR-1855162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Xenopus tropicalis)
RHEA:61851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + UDP-alpha-D-glucose <=> cholesteryl 3-beta-D-glucoside + H(+) + UDP
REACT:R-SSC-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Sus scrofa)
REACT:R-HSA-5580269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP11A1 does not cleave 20a,22b-DHCHOL (Homo sapiens)
REACT:R-MMU-444047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR3 binds carboxylates (Mus musculus)
REACT:R-MMU-5225649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP7 binds histone H3 (Mus musculus)
RHEA:15750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-mandelate + A => AH2 + phenylglyoxylate
RHEA:68692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) = 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-1855208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Canis familiaris)
REACT:R-MMU-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Mus musculus)
RHEA:57370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-NADPHX => H2O + NADPH
RHEA:70295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-sulfino-L-alanine = 3-sulfinopyruvate + L-glutamate
REACT:R-MMU-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Mus musculus)
REACT:R-BTA-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Bos taurus)
RHEA:44072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DME-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Drosophila melanogaster)
RHEA:13740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an n-alkanal + NADP(+) <=> an alk-2-enal + H(+) + NADPH
REACT:R-SSC-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Sus scrofa)
RHEA:66112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-tyrosine = (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate
RHEA:66294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose
REACT:R-GGA-5693584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Gallus gallus)
GO:0102201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-2-epi-prezizaene synthase activity
REACT:R-MMU-936952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Mus musculus)
RHEA:65160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + hexan-2-ol = CoA + hexan-2-yl benzoate
REACT:R-DRE-432096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated integrin alphaIIb beta3 binds SHC1 (Danio rerio)
RHEA:35521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O
RHEA:28644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => alpha-zingiberene + diphosphate
RHEA:63772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
REACT:R-HSA-193694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 is recruited and forms a complex with TRAF6 (Homo sapiens)
RHEA:39269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+) => (15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH
REACT:R-RNO-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Rattus norvegicus)
REACT:R-DRE-8983835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Danio rerio)
REACT:R-MMU-114275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BAX at the mitochondrial membrane (Mus musculus)
REACT:R-BTA-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Bos taurus)
EC:6.2.1.39	skos:prefLabel	"[butirosin acyl-carrier protein]--L-glutamate ligase"
EC:6.2.1.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[butirosin acyl-carrier protein]--L-glutamate ligase"
EC:6.2.1.39	skos:altLabel	"[BtrI acyl-carrier protein]--L-glutamate ligase"
REACT:R-GGA-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Gallus gallus)
RHEA:54139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(48) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-170977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 is phosphorylated by active TrkA receptor (Canis familiaris)
RHEA:62031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + stigmasteryl 3-beta-D-glucoside <=> D-glucose + stigmasterol
REACT:R-MMU-2995376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Mus musculus)
RHEA:16266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate => 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-5688786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds RAD23 (Rattus norvegicus)
RHEA:13580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a wax ester + H2O <=> a long chain fatty alcohol + a long-chain fatty acid + H(+)
REACT:R-MMU-8852266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Mus musculus)
REACT:R-RNO-390593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Rattus norvegicus)
GO:0047337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-diphosphate:polyphosphate phosphotransferase activity
GO:0047337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-diphosphate-polyphosphate phosphotransferase activity
GO:0047337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichylpyrophosphate:polyphosphate phosphotransferase activity
RHEA:60032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GTP + H2O = 8-oxo-GDP + H(+) + phosphate
RHEA:37259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + H2O + NAD(+) = 2-oxobutanoate + H(+) + NADH + NH4(+)
REACT:R-HSA-8938773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A polyubiquitinates PRKDC (Homo sapiens)
REACT:R-CEL-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Caenorhabditis elegans)
RHEA:49556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate
REACT:R-MMU-9696266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds effectors (Mus musculus)
REACT:R-RNO-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Rattus norvegicus)
RHEA:59587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-lysine <=> ADP + beta-alanyl-L-lysine + H(+) + phosphate
RHEA:46868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
RHEA:48334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose
EC:2.1.1.207	skos:altLabel	"tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase"
EC:2.1.1.207	skos:altLabel	"tRNA methyltransferase L"
EC:2.1.1.207	skos:prefLabel	"tRNA (cytidine(34)-2'-O)-methyltransferase"
EC:2.1.1.207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (cytidine(34)-2'-O)-methyltransferase"
REACT:R-BTA-9038029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxysterol binds ESR1, ESR2 (Bos taurus)
GO:0097603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	temperature-activated ion channel activity
GO:0097603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	temperature-dependent ion channel activity
GO:0097603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	temperature gated ion channel activity
GO:0097603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	temperature-gated ion channel activity
GO:0097603	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heat-activated ion channel activity
REACT:R-GGA-5684108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 binds phosphorylated RBBP8 (Gallus gallus)
EC:3.2.1.131	skos:prefLabel	"xylan alpha-1,2-glucuronosidase"
EC:3.2.1.131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylan alpha-1,2-glucuronosidase"
REACT:R-CFA-9026408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Canis familiaris)
REACT:R-DRE-622420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Danio rerio)
REACT:R-CEL-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Caenorhabditis elegans)
REACT:R-CFA-2172666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds condensin II (Canis familiaris)
REACT:R-GGA-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Gallus gallus)
REACT:R-PFA-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Plasmodium falciparum)
REACT:R-HSA-1295609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates SPRY2 on Y55 and Y227 (Homo sapiens)
REACT:R-MMU-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Mus musculus)
RHEA:47488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isodeoxycholate + NADP(+)
REACT:R-SSC-3296309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR3 binds HCAR3 ligands (Sus scrofa)
RHEA:57924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mutildienyl diphosphate = diphosphate + premutilin
RHEA:21735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + L-glutamine <=> anthranilate + H(+) + L-glutamate + pyruvate
RHEA:28377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
RHEA:32846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol
REACT:R-RNO-9731924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds EDNs (Rattus norvegicus)
RHEA:13153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + CO2 + NAD(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH
REACT:R-MMU-9008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylation (Mus musculus)
RHEA:49634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+) => (2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate
RHEA:62110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacyl-sn-glycero-3-phosphoethanolamine + CoA => an acyl-CoA + sn-glycero-3-phosphoethanolamine
REACT:R-XTR-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Xenopus tropicalis)
GO:0050137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:hydrogen-peroxide oxidoreductase activity
GO:0050137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPNH peroxidase activity
GO:0050137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH peroxidase activity
GO:0050137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP peroxidase activity
GO:0050137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triphosphopyridine nucleotide peroxidase activity
GO:0050137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide phosphate peroxidase activity
GO:0050137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPN peroxidase activity
REACT:R-SCE-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Saccharomyces cerevisiae)
RHEA:53191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine
REACT:R-MMU-9027273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Mus musculus)
REACT:R-SSC-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Sus scrofa)
REACT:R-DRE-5696230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO1 dimer reduces methylarsonate to methylarsonite (Danio rerio)
REACT:R-RNO-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Rattus norvegicus)
REACT:R-HSA-8849350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Homo sapiens)
REACT:R-GGA-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Gallus gallus)
REACT:R-RNO-8871373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMX phosphorylates RUFY1 (Rattus norvegicus)
REACT:R-DRE-380278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Danio rerio)
RHEA:50080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurodeoxycholate(in) = ADP + H(+) + phosphate + taurodeoxycholate(out)
RHEA:52707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UMP <=> D-ribose 5-phosphate + uracil
GO:0016247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	channel regulator activity
REACT:R-XTR-5684275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Xenopus tropicalis)
REACT:R-SPO-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Schizosaccharomyces pombe)
RHEA:18478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + O2 => 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)
RHEA:64719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propanal <=> acrolein + H(+) + NADPH
RHEA:11753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylsalicylate + H2O => acetate + H(+) + salicylate
RHEA:51529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + vanillate => CO2 + guaiacol
RHEA:53887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-glucose + D-glucose 6-phosphate <=> alpha,alpha-trehalose 6-phosphate + CDP + H(+)
RHEA:12334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Fe(3+)(in) + H(+) + phosphate => ATP + Fe(3+)(out) + H2O
EC:1.5.1.39	skos:prefLabel	"FMN reductase [NAD(P)H]"
EC:1.5.1.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FMN reductase [NAD(P)H]"
REACT:R-CFA-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Canis familiaris)
REACT:R-HSA-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Homo sapiens)
REACT:R-RNO-139906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of BAD by calcineurin (Rattus norvegicus)
REACT:R-SSC-2160884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Sus scrofa)
GO:0005516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calmodulin binding
RHEA:66025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O
REACT:R-DRE-5621370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Danio rerio)
RHEA:47529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isocholate + NADP(+)
RHEA:21270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	berberine + H(+) + 2 NADPH => (R)-canadine + 2 NADP(+)
REACT:R-SSC-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Sus scrofa)
REACT:R-HSA-1535903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Homo sapiens)
REACT:R-RNO-1370500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR binds SCF beta-TrCP complex (Rattus norvegicus)
REACT:R-RNO-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Rattus norvegicus)
REACT:R-HSA-202168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ZAP-70 by Lck (Homo sapiens)
REACT:R-RNO-5423672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2, 3A4 oxidise AFB1 to AFNBO (Rattus norvegicus)
REACT:R-CEL-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Caenorhabditis elegans)
REACT:R-MMU-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Mus musculus)
RHEA:24922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine <=> 2-aminobut-2-enoate + H2O
REACT:R-MMU-8964619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds ARHGEF6 (Mus musculus)
REACT:R-MMU-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Mus musculus)
RHEA:41282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoylsphing-4-enine <=> octadecanoate + sphing-4-enine
RHEA:50175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine
RHEA:69117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + glycine
REACT:R-CFA-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Canis familiaris)
GO:0035401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3Y41 kinase activity
GO:0035401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone tyrosine kinase activity (H3-Y41 specific)
GO:0035401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H3-Y41 specific)
GO:0035401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-tyrosine kinase activity (H3-Y41 specific)
GO:0035401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-Y41 kinase activity
RHEA:65964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurocholate(out) = ADP + H(+) + phosphate + taurocholate(in)
REACT:R-BTA-213407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from SLP-76 (Bos taurus)
REACT:R-DRE-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Danio rerio)
REACT:R-HSA-2482180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VIII degradation by ELANE (Homo sapiens)
RHEA:54921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + NADP(+) => 13-cis-retinal + H(+) + NADPH
RHEA:59937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)
REACT:R-DME-8866941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MID1IP1 binds THRSP (Drosophila melanogaster)
REACT:R-CFA-8951500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CANX from nonameric complex (Canis familiaris)
REACT:R-MMU-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Mus musculus)
RHEA:47722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + xanthine => H(+) + H2O + isoguanine
RHEA:51021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + 2 Fe(III)-[cytochrome c] => an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)
GO:0034844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthyl-2-methyl-succinate CoA-transferase activity
REACT:R-MMU-390912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds hist (Mus musculus)
RHEA:67305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 => H2O2 + myceliothermophin E
RHEA:14464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose <=> (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP
REACT:R-CEL-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Caenorhabditis elegans)
RHEA:48769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-erythrulose => ADP + D-erythrulose 4-phosphate + H(+)
REACT:R-SSC-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Sus scrofa)
REACT:R-SSC-398193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC beta-mediated PIP2 hydrolysis (Sus scrofa)
RHEA:44853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(5Z)-tetradecenoyl-(R)-carnitine
RHEA:28932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate
REACT:R-SSC-5229010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-27 of histone H3 (H3R26) (Sus scrofa)
GO:0018523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinoline 2-oxidoreductase activity
GO:0018523	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinoline:acceptor 2-oxidoreductase (hydroxylating)
RHEA:55898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2
REACT:R-DME-8941312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Drosophila melanogaster)
REACT:R-SSC-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Sus scrofa)
REACT:R-GGA-5654408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS2 (Gallus gallus)
RHEA:36539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinganine = CoA + H(+) + N-hexadecanoylsphinganine
REACT:R-RNO-388831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CD28 (Rattus norvegicus)
REACT:R-HSA-2230938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin:Haptoglobin:CD163 is endocytosed (Homo sapiens)
RHEA:48255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD2 + UDP-alpha-D-galactose <=> ganglioside GD1b + H(+) + UDP
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(HAMCL) depolymerase activity
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly((R)-3-hydroxyoctanoate) hydrolase activity
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	poly((R)-hydroxyalkanoic acid) depolymerase activity
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PHO depolymerase activity
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	poly(HA) depolymerase activity
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly[(R)-3-hydroxyoctanoate] hydrolase activity
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	poly[(R)-hydroxyalkanoic acid] depolymerase
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(3-hydroxyoctanoate) depolymerase activity
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(3HO) depolymerase activity
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(HA(MCL)) depolymerase activity
GO:0050527	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PHA depolymerase activity
REACT:R-HSA-452091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)
REACT:R-DME-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Drosophila melanogaster)
REACT:R-RNO-9674127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
RHEA:57874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + umbelliferone => (E)-2,4-dihydroxycinnamoyl-CoA
RHEA:67313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => myceliothermophin E
REACT:R-MMU-5675194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPK phosphorylates RAF1 (Mus musculus)
REACT:R-HSA-8854071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)
GO:0047680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryl-acylamidase activity
GO:0047680	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pseudocholinesterase (associated with arylacylamidase)
GO:0047680	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	brain acetylcholinesterase (is associated with AAA-2)
GO:0047680	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AAA-2
GO:0047680	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AAA-1
GO:0047680	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-acylamide amidohydrolase activity
GO:0046481	skos:prefLabel	"digalactosyldiacylglycerol synthase"
GO:0046481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP
GO:0046481	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DGD2
GO:0046481	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DGDG synthase activity
GO:0046481	skos:altLabel	"UDP-galactose-dependent digalactosyldiacylglycerol synthase"
GO:0046481	skos:altLabel	"DGDG synthase"
GO:0046481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-dependent digalactosyldiacylglycerol synthase activity
GO:0046481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digalactosyldiacylglycerol synthase activity
GO:0046481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose:MGDG galactosyltransferase activity
GO:0046481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity
GO:0046481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-dependent DGDG synthase activity
GO:0046481	skos:altLabel	"UDP-galactose-dependent DGDG synthase"
GO:0046481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"digalactosyldiacylglycerol synthase"
GO:0046481	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DGD1
GO:0046481	skos:altLabel	"UDP-galactose:MGDG galactosyltransferase"
REACT:R-HSA-8987202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)
REACT:R-DRE-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Danio rerio)
GO:0046943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane (Homo sapiens)
GO:0046943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxylic acid transmembrane transporter activity
RHEA:68233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(in) + Na(+)(in) => L-cysteine(out) + Na(+)(out)
REACT:R-RNO-3769383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBY1 binds beta-catenin (Rattus norvegicus)
REACT:R-XTR-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)
REACT:R-HSA-1592297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full activation of MMP1 (Homo sapiens)
RHEA:33072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate => 2-deoxy-L-scyllo-inosose + phosphate
RHEA:60317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-SSC-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Sus scrofa)
RHEA:45939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA
GO:0047140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione--CoA-glutathione transhydrogenase"
GO:0047140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:coenzyme A-glutathione transhydrogenase activity
GO:0047140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione-coenzyme A glutathione disulfide transhydrogenase activity
GO:0047140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CoA:glutathione-disulfide oxidoreductase activity
GO:0047140	skos:prefLabel	"glutathione--CoA-glutathione transhydrogenase"
GO:0047140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione coenzyme A-glutathione transhydrogenase activity
GO:0047140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-CoA-glutathione transhydrogenase activity
GO:0047140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glutathione disulfide = CoA-glutathione + glutathione
GO:0047140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme A:oxidized-glutathione oxidoreductase activity
GO:0047140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme A:glutathione-disulfide oxidoreductase activity
REACT:R-XTR-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Xenopus tropicalis)
RHEA:70353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose => beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O
REACT:R-CFA-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Canis familiaris)
RHEA:24315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[cytochrome c] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine
RHEA:44489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
GO:0016263	skos:altLabel	"glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase"
GO:0016263	skos:prefLabel	"N-acetylgalactosaminide beta-1,3-galactosyltransferase"
GO:0016263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylgalactosaminide beta-1,3-galactosyltransferase"
GO:0016263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity
GO:0016263	skos:altLabel	"uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase"
GO:0016263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP
GO:0016263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity
GO:0016263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
GO:0016263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity
GO:0016263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Core 1 GalT
RHEA:55947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloroethanol + 2 Fe(III)-[cytochrome c] <=> chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-GGA-141186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
RHEA:72801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-homoarginine(out) => L-arginine(out) + L-homoarginine(in)
REACT:R-DRE-9020262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Danio rerio)
RHEA:68356	skos:altLabel	"folate hydrolase"
RHEA:68356	skos:altLabel	"N-acetylated-gamma-linked-acidic dipeptidase"
RHEA:68356	skos:altLabel	"pteroylpoly-gamma-glutamate carboxypeptidase"
RHEA:68356	skos:prefLabel	"glutamate carboxypeptidase II"
RHEA:68356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate carboxypeptidase II"
RHEA:68356	skos:altLabel	"NAALADase"
RHEA:68356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-aspartyl-L-glutamate = L-glutamate + N-acetyl-L-aspartate
REACT:R-GGA-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Gallus gallus)
REACT:R-HSA-6782264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs (Homo sapiens)
RHEA:34759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycerol 2-phosphate(out) + H2O = ADP + glycerol 2-phosphate(in) + H(+) + phosphate
REACT:R-SSC-1236956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfment of particulate antigen into phagocytic vesicle (Sus scrofa)
REACT:R-BTA-202168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ZAP-70 by Lck (Bos taurus)
GO:0015548	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	organomercurial transporter activity
GO:0015548	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity
GO:0015548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organomercurial transmembrane transporter activity
RHEA:42798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z,12Z)-octadecadienoate + CoA => (9Z,12Z)-octadecadienoyl-CoA + cholesterol
RHEA:37919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
REACT:R-HSA-6807052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBP isomerizes ZYMSTNL to LTHSOL (Homo sapiens)
RHEA:45341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O => (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)
REACT:R-DME-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Drosophila melanogaster)
REACT:R-CFA-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Canis familiaris)
REACT:R-DDI-9018858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Dictyostelium discoideum)
GO:0050103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextrin 6-glucosyltransferase activity
GO:0050103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextran dextrinase activity
GO:0050103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dextrin dextranase activity
GO:0050103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity
GO:0017065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-strand selective monofunctional uracil-DNA glycosylase activity
GO:0017065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-strand selective uracil DNA N-glycosylase activity
GO:0017065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by SMUG1 glycosylase (Homo sapiens)
REACT:R-CEL-6807055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR7 reduces 7-dehydroCHOL to CHOL (Caenorhabditis elegans)
GO:0005119	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	smoothened ligand
GO:0005119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	smo binding
GO:0005119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	smoothened binding
GO:0005119	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	smo ligand
REACT:R-SSC-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Sus scrofa)
RHEA:55049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-dodecadienoyl-CoA + H2O => (3E,5Z)-dodecadienoate + CoA + H(+)
RHEA:28855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + melibiose(in) = H(+)(out) + melibiose(out)
REACT:R-HSA-5693153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1K dephosphorylates p-BCKDH (Homo sapiens)
RHEA:28096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate => di-trans,octa-cis-undecaprenyl diphosphate + H2O
REACT:R-HSA-429016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 is phosphorylated by MAPKAP2 (Homo sapiens)
REACT:R-DME-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Drosophila melanogaster)
RHEA:37327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-methionyl-L-alanine(out) = ADP + H(+) + L-methionyl-L-alanine(in) + phosphate
REACT:R-DDI-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Dictyostelium discoideum)
GO:0072582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0072582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 17beta-hydroxy steroid + NADP(+) = a 17-oxo steroid + H(+) + NADPH
RHEA:15052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-glucose + H2O <=> D-glucose + GDP + H(+)
RHEA:26014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7-dideoxy-D-threo-hepto-2,6-diuolosonate = 3-dehydroquinate
RHEA:35472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine => (+)-pisatin + H(+) + S-adenosyl-L-homocysteine
GO:0031699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-3 adrenergic receptor binding
GO:0031699	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-3 adrenergic receptor ligand
REACT:R-DRE-8852354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)
RHEA:30006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
REACT:R-CEL-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Caenorhabditis elegans)
REACT:R-CFA-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Canis familiaris)
RHEA:35486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-8950423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)
REACT:R-SCE-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Saccharomyces cerevisiae)
REACT:R-HSA-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Homo sapiens)
REACT:R-GGA-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Gallus gallus)
REACT:R-MMU-204773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb7 (Mus musculus)
REACT:R-CEL-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Caenorhabditis elegans)
RHEA:42361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allulose => keto-D-fructose
REACT:R-MMU-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)
REACT:R-SSC-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Sus scrofa)
REACT:R-RNO-1482776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Rattus norvegicus)
REACT:R-MMU-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
REACT:R-CFA-1606789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses DS (Canis familiaris)
RHEA:14527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + alpha-cyclopiazonate => A + beta-cyclopiazonate
RHEA:40357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP
RHEA:46713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine
GO:0097257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Homo sapiens)
GO:0097257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 12-hydroxy dehydrogenase activity
GO:0097257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 12-hydroxydehydrogenase activity
GO:0097257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH
GO:0062122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-methyltransferase activity (H3-K37 specific)
GO:0062122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3K37 methyltransferase activity
GO:0062122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K37 methyltransferase activity
GO:0062122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-K37 specific)
GO:0062122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K37 methylase activity
RHEA:46047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-octenoyl-CoA <=> (2E)-octenoyl-CoA
REACT:R-SPO-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Schizosaccharomyces pombe)
REACT:R-BTA-8956676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TP73 (Bos taurus)
REACT:R-HSA-189208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Homo sapiens)
RHEA:24524	skos:prefLabel	"20-oxo-5-O-mycaminosyltylactone 23-monooxygenase"
RHEA:24524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"20-oxo-5-O-mycaminosyltylactone 23-monooxygenase"
RHEA:24524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Danio rerio)
REACT:R-DRE-8944214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type I (Danio rerio)
REACT:R-BTA-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Bos taurus)
RHEA:17075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + cortisol 21-acetate => acetyl-CoA + cortisol
REACT:R-BTA-380283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Bos taurus)
REACT:R-RNO-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Rattus norvegicus)
GO:0018640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene + FMNH2 + O2 = dibenzothiophene 5-oxide + FMN + H(+) + H2O
GO:0018640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene monooxygenase activity
REACT:R-MMU-111742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)
REACT:R-XTR-202365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
RHEA:45912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)
REACT:R-CEL-373716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacting NCK-1 (Caenorhabditis elegans)
GO:0008767	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-galactopyranose furanomutase activity
GO:0008767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactopyranose mutase activity
GO:0008767	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactopyranose mutase activity
REACT:R-XTR-109470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Xenopus tropicalis)
REACT:R-MMU-5225602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR5 binds Me2sR3-replicative histone H3 (Mus musculus)
REACT:R-GGA-4551727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Gallus gallus)
REACT:R-MMU-9027272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Mus musculus)
REACT:R-HSA-8951690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 (Homo sapiens)
REACT:R-MMU-1855200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Mus musculus)
REACT:R-SSC-174120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Sus scrofa)
REACT:R-SSC-167408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The high affinity receptor complex binds to G-protein (Sus scrofa)
GO:0004185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine carboxypeptidase activity
GO:0004185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-type carboxypeptidase activity
GO:0034584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	piRNA binding
GO:0034584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Piwi-associated RNA binding
REACT:R-SSC-430183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK binds PAK (Sus scrofa)
REACT:R-HSA-1675815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P transports from the Golgi membrane to the plasma membrane (Homo sapiens)
REACT:R-GGA-74718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalisation of the insulin receptor (Gallus gallus)
RHEA:56320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose = an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP
REACT:R-SSC-5685341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex stabilizes RAD51 filament (Sus scrofa)
REACT:R-MMU-187828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p21 to the nucleus (Mus musculus)
REACT:R-SCE-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)
REACT:R-CFA-5423647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)
REACT:R-CEL-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Caenorhabditis elegans)
RHEA:15956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + ATP <=> ADP + 2 H(+) + N(4)-phosphoagmatine
GO:0050309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sugar-terminal-phosphatase activity
GO:0050309	skos:prefLabel	"sugar-terminal-phosphatase"
GO:0050309	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	xylitol-5-phosphatase activity
GO:0050309	skos:altLabel	"xylitol-5-phosphatase"
GO:0050309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sugar-terminal-phosphatase"
GO:0050309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sugar-omega-phosphate phosphohydrolase activity
REACT:R-DME-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Drosophila melanogaster)
RHEA:17338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + O2 => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)
REACT:R-SSC-1676174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Sus scrofa)
REACT:R-MMU-1678742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses Heparan sulfate chain(4) (Mus musculus)
RHEA:54095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)
REACT:R-SPO-5651657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)
REACT:R-CFA-174202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Securin (Canis familiaris)
REACT:R-HSA-8985591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2-bound ROBO1 binds MYO9B (Homo sapiens)
REACT:R-HSA-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Homo sapiens)
REACT:R-BTA-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
RHEA:70326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxo-L-gulonate <=> 2-carboxy-L-lyxonolactone
REACT:R-XTR-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Xenopus tropicalis)
RHEA:67046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chermesin D => A + asnovolin H
REACT:R-MMU-6785342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Mus musculus)
REACT:R-RNO-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Rattus norvegicus)
REACT:R-XTR-388560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA,EDNRB bind EDNs (Xenopus tropicalis)
REACT:R-SSC-8849068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARHGAP35 (Sus scrofa)
REACT:R-SSC-8983872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Sus scrofa)
REACT:R-SSC-1793209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses Chondroitin chains (Sus scrofa)
GO:0052590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity
RHEA:59654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotetraonate + H(+) => D-xylotetraono-1,5-lactone + H2O
REACT:R-CFA-1564142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV degradation by MMP2,3,4,9,10,12 (Canis familiaris)
RHEA:15534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH
REACT:R-SSC-8849428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 binds PTK6 (Sus scrofa)
RHEA:50300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]
REACT:R-BTA-3134883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin enhances association of IRF3 with CBP/p300  (Bos taurus)
RHEA:32345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-thujan-3-one + H(+) + NADH => (+)-thujan-3-ol + NAD(+)
REACT:R-DRE-164840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP and Pi bind to ATPase (Danio rerio)
REACT:R-CEL-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Caenorhabditis elegans)
RHEA:17334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + zeatin => acetate + H(+) + L-lupinate
REACT:R-MMU-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Mus musculus)
REACT:R-MMU-432096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
REACT:R-MMU-202365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
REACT:R-BTA-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Bos taurus)
REACT:R-CEL-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Caenorhabditis elegans)
REACT:R-RNO-3247569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADI4 deiminates Histones (Rattus norvegicus)
RHEA:52658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH => a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+)
REACT:R-RNO-9726875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCNs:cAMP bind SNIs (Rattus norvegicus)
RHEA:27964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pyrroloquinoline quinol + scyllo-inosose => myo-inositol + pyrroloquinoline quinone
REACT:R-DRE-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Danio rerio)
REACT:R-DRE-209566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is auto-ubiquitinated (Danio rerio)
GO:0052607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-hydroxychlorophyllide a:oxygen 7-oxidoreductase activity
GO:0052607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-hydroxychlorophyllide-a oxygenase activity
GO:0052607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll b synthetase activity
GO:0052607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxy-chlorophyllide a oxygenase activity
GO:0052607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorophyll-b synthase activity
GO:0052607	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CAO activity
GO:0102462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-sophoroside 7-O-rhamnosyltransferase activity
REACT:R-RNO-8938853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 binds RUNX1 (Rattus norvegicus)
REACT:R-BTA-1483159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)
REACT:R-CFA-9706354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of FLT3 (Canis familiaris)
REACT:R-RNO-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Rattus norvegicus)
REACT:R-SSC-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Sus scrofa)
RHEA:67929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O => a 3'-end 3'-phosphouridine-RNA + H(+)
GO:0004307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
GO:0004307	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diacylglycerol ethanolaminephosphotransferase activity
GO:0004307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolaminephosphotransferase activity
GO:0004307	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylethanolamine-glyceride transferase activity
GO:0004307	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	EPT
GO:0004307	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity
GO:0004307	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPethanolamine diglyceride phosphotransferase activity
RHEA:70962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tyrosine + H2O + O2 <=> 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)
RHEA:60735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + perillyl aldehyde <=> 2 H(+) + NADPH + perillate
RHEA:26407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+)
RHEA:58966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + hexanoate => H2O + hexanal + O2
RHEA:15866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + tryptamine => 4-hydroxytryptamine + A + H2O
GO:0031881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 4 somatostatin receptor binding
GO:0031881	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 4 somatostatin receptor ligand
REACT:R-HSA-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Homo sapiens)
RHEA:62900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)
RHEA:53114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH => 3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+)
REACT:R-SPO-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Schizosaccharomyces pombe)
REACT:R-SSC-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Sus scrofa)
REACT:R-RNO-4722133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Rattus norvegicus)
GO:0102085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(4-aminobenzoyl)-L-glutamate synthetase activity
REACT:R-RNO-8876446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ULK1 phosphorylates DENND3 (Rattus norvegicus)
REACT:R-SSC-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Sus scrofa)
RHEA:72545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in) => 2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out)
REACT:R-BTA-5218832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds PAK2 (Bos taurus)
REACT:R-HSA-372705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
REACT:R-CEL-71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)
REACT:R-SPO-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Schizosaccharomyces pombe)
REACT:R-SSC-1250380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Sus scrofa)
REACT:R-DRE-388809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTLA-4 binds B7-1/B7-2 (Danio rerio)
RHEA:71805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(in) + H(+)(in) => acetate(out) + H(+)(out)
RHEA:33768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-hydroxy-fatty acyl-CoA => a (2E)-enoyl-CoA + H2O
GO:0048031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trisaccharide binding
REACT:R-SCE-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Saccharomyces cerevisiae)
RHEA:11447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate
REACT:R-BTA-909720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN alpha/beta binds to IFNAR2 (Bos taurus)
RHEA:70082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + clavatol + O2 <=> CO2 + hydroxyclavatol + succinate
REACT:R-CFA-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)
GO:0008013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin binding
REACT:R-XTR-4085029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU2 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)
RHEA:27745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + adenine
REACT:R-HSA-9029158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
RHEA:54354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline
RHEA:15019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + phosphate => a phosphate monoester + H2O
RHEA:43086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA + S-adenosyl-L-methionine
REACT:R-DRE-6814670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Danio rerio)
REACT:R-CFA-8849348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Canis familiaris)
REACT:R-HSA-9012556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Homo sapiens)
RHEA:65574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-5666008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCAI binds SRF:MKL1 (Gallus gallus)
RHEA:51068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate = (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine
RHEA:69517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-galactosamine + O2 => H2O2 + N-acetyl-D-galactosamino-1,5-lactone
REACT:R-XTR-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)
REACT:R-RNO-177936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Rattus norvegicus)
REACT:R-XTR-8941234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Xenopus tropicalis)
RHEA:48419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) <=> CMP + ganglioside GM2 (d18:1(4E)) + H(+)
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GBSSII
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	granule-bound starch synthase activity
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	granule-bound starch synthase I activity
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	granule-bound starch synthase II activity
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDP-glucose-starch glucosyltransferase activity
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	waxy protein
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	starch synthase II activity
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GBSS
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GBSSI
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity
GO:0033840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDPglucose-starch glucosyltransferase activity
RHEA:59691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaose + O2 <=> D-maltoheptaono-1,5-lactone + H2O2
REACT:R-SSC-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Sus scrofa)
REACT:R-XTR-5676607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF,sAPRIL binds TACI,BCMA (Xenopus tropicalis)
REACT:R-DRE-8950441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Danio rerio)
REACT:R-HSA-139893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Granzyme-B activates BID by cleavage (Homo sapiens)
REACT:R-GGA-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Gallus gallus)
RHEA:33227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2
REACT:R-XTR-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Xenopus tropicalis)
RHEA:62581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-cystine(out) + H2O => ADP + D-cystine(in) + H(+) + phosphate
RHEA:71482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin <=> L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)
REACT:R-MMU-5578966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A:AGO2:miRNA is transported into the nucleus (Mus musculus)
RHEA:43844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 = (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)
REACT:R-HSA-9027670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binding induces ESR depalmitoylation (Homo sapiens)
RHEA:33646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoate + ATP + CoA <=> (9Z)-tetradecenoyl-CoA + AMP + diphosphate
REACT:R-CEL-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Caenorhabditis elegans)
GO:0001626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORPH receptor
GO:0001626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OFQ receptor activity
GO:0001626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	X-opioid receptor activity
GO:0001626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nociceptin receptor activity
GO:0001626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orphanin-FQ receptor activity
GO:0001626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nociceptin/orphanin-FQ receptor activity
REACT:R-DDI-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Dictyostelium discoideum)
REACT:R-SCE-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Saccharomyces cerevisiae)
REACT:R-XTR-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Xenopus tropicalis)
REACT:R-DRE-451366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38MAPK by DSCAM (Danio rerio)
REACT:R-HSA-5676596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds BAFFR:BAFF (Homo sapiens)
REACT:R-HSA-114419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 (Homo sapiens)
REACT:R-BTA-4084984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Bos taurus)
RHEA:46218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxypregn-4-ene-20-one + NADP(+) => H(+) + NADPH + progesterone
REACT:R-DRE-8964274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12) binds BTK (Danio rerio)
REACT:R-SPO-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Schizosaccharomyces pombe)
REACT:R-DRE-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Danio rerio)
RHEA:20599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-cystine + NADH => 2 L-cysteine + NAD(+)
REACT:R-HSA-187828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p21 to the nucleus (Homo sapiens)
REACT:R-BTA-9645535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 phosphorylates TIFA (Bos taurus)
REACT:R-BTA-266315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + spherical HDL <=> LCAT:spherical HDL complex (Bos taurus)
REACT:R-DME-209240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5 (Drosophila melanogaster)
REACT:R-MMU-3322429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP monoubiquinates TLE (Mus musculus)
REACT:R-SSC-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Sus scrofa)
RHEA:11626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone oxime + pyruvate => 2-(hydroxyimino)propanoate + acetone
RHEA:15746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->1)-beta-D-fructosyl](n) + sucrose => [(2->1)-beta-D-fructosyl](n+1) + D-glucose
REACT:R-DRE-1236943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigen peptide onto MHC class I molecule (Danio rerio)
REACT:R-CFA-8982162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Canis familiaris)
RHEA:40627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trihexadecanoylglycerol = 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate
RHEA:52609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybutanoate + NADP(+) => 2-oxobutanoate + H(+) + NADPH
RHEA:29137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+)(out) + H2O + nitrite => a menaquinol + 2 H(+)(in) + nitrate
REACT:R-XTR-169904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3G stimulates nucleotide exchange on Rap1 (Xenopus tropicalis)
REACT:R-DME-9749583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Drosophila melanogaster)
GO:0097246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechin binding
RHEA:31088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + octanoyl-CoA => 3-oxodecanoyl-CoA + CoA
GO:0086056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in AV node cell action potential
GO:0086056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in atrioventricular node cardiac muscle cell action potential
GO:0086056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in AV node cardiac muscle cell action potential
REACT:R-XTR-9007283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 and PRC1.6 associate with E2F6.com-1 (Xenopus tropicalis)
REACT:R-HSA-9625828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1 binds RETN gene promoter (Homo sapiens)
REACT:R-SSC-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Sus scrofa)
RHEA:20271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5-dehydro-4-deoxy-D-glucuronate => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate
REACT:R-CEL-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
RHEA:52541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + phosphate => alpha-D-ribose 1-phosphate + cytosine
REACT:R-SSC-201629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Tau (Sus scrofa)
RHEA:38728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol
REACT:R-SSC-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Sus scrofa)
RHEA:53625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + tsukubadiene
RHEA:19075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein] => ATP + L-seryl-[I-kappa-B protein]
RHEA:30146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoyl-CoA <=> CoA + H(+) + octanoate
REACT:R-DRE-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Danio rerio)
RHEA:57992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside C-K + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP
RHEA:62492	skos:prefLabel	"L-arginine--[L-arginyl-carrier protein] ligase"
RHEA:62492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arginine--[L-arginyl-carrier protein] ligase"
RHEA:62492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-arginine = AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]
GO:0004689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen phosphorylase kinase activity
GO:0004689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:phosphorylase-b phosphotransferase activity
GO:0004689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PHK
GO:0004689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK17
GO:0004689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dephosphophosphorylase kinase activity
GO:0004689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylase B kinase activity
GO:0004689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylase kinase, intrinsic catalyst activity
GO:0004689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylase kinase activity
GO:0004689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylase kinase (phosphorylating) activity
RHEA:23173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]
RHEA:69815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cathasterone + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone
REACT:R-MMU-2997709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO1 (Mus musculus)
REACT:R-GGA-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Gallus gallus)
REACT:R-GGA-2168885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin binds Hemoglobin (Gallus gallus)
REACT:R-GGA-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Gallus gallus)
REACT:R-CFA-8850818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK9 binds KLK5 (Canis familiaris)
RHEA:26287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-6A + S-adenosyl-L-homocysteine => Co-precorrin-5B + S-adenosyl-L-methionine
RHEA:38976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-CFA-400204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds RXRA (Canis familiaris)
RHEA:56400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)
GO:0015930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate synthase activity
REACT:R-BTA-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Bos taurus)
RHEA:68640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = diphosphate + limonene
REACT:R-RNO-8944261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIII (Rattus norvegicus)
RHEA:10347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-432162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
RHEA:70239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside
RHEA:21415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH
REACT:R-RNO-9617927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO4 binds ATXN3 (Rattus norvegicus)
RHEA:34417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1R,4R)-bornane-2,5-dione + FMNH2 + O2
REACT:R-XTR-4551655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Xenopus tropicalis)
RHEA:14380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-aspartate <=> glycine + glyoxylate
RHEA:42341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH
REACT:R-BTA-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Bos taurus)
RHEA:38572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(in) => a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
GO:0052660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-propane-1,2-diol:NAD+ oxidoreductase activity
GO:0052660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	R-lactaldehyde reductase activity
GO:0052660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lactaldehyde:propanediol oxidoreductase activity
REACT:R-HSA-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Homo sapiens)
GO:0050088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity
GO:0050088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity
GO:0050088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-mannose-6-P reductase activity
GO:0050088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent mannose 6-phosphate reductase activity
GO:0050088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent M6P reductase activity
GO:0050088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannose-6-phosphate reductase activity
GO:0050088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose-6-phosphate 6-reductase activity
GO:0050088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphomannose reductase activity
RHEA:64400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-amino acid tripeptide(out) + H(+)(out) = an L-amino acid tripeptide(in) + H(+)(in)
REACT:R-MMU-909718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of p-STAT1 homodimer (Mus musculus)
RHEA:31489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + soyasaponin III + UDP => soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose
REACT:R-MMU-3322422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits SMARCA4 (Mus musculus)
REACT:R-CEL-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Caenorhabditis elegans)
REACT:R-HSA-9020277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Homo sapiens)
REACT:R-GGA-8985343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SOX9 (Gallus gallus)
RHEA:14053	skos:altLabel	"3-deoxy-D-mannooctulosonate-8-phosphate synthetase"
RHEA:14053	skos:altLabel	"3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase"
RHEA:14053	skos:altLabel	"3-deoxy-D-manno-octulosonate-8-phosphate synthase"
RHEA:14053	skos:altLabel	"KDO-8-P synthase"
RHEA:14053	skos:altLabel	"2-keto-3-deoxy-8-phosphooctonic synthetase"
RHEA:14053	skos:altLabel	"KDOP synthase"
RHEA:14053	skos:altLabel	"3-deoxyoctulosonic 8-phosphate synthetase"
RHEA:14053	skos:altLabel	"2-dehydro-3-deoxy-phosphooctonate aldolase"
RHEA:14053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-8-phosphooctulonate synthase"
RHEA:14053	skos:altLabel	"2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating)"
RHEA:14053	skos:altLabel	"KDO-8-phosphate synthetase"
RHEA:14053	skos:altLabel	"phospho-2-keto-3-deoxyoctonate aldolase"
RHEA:14053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate
RHEA:14053	skos:prefLabel	"3-deoxy-8-phosphooctulonate synthase"
REACT:R-SSC-9727198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B exchanges K+ for H+ (Sus scrofa)
RHEA:38661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O
RHEA:52174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Bos taurus)
REACT:R-XTR-5604929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C binds Protein S (Xenopus tropicalis)
REACT:R-CFA-183094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds CBL:Beta-Pix (Canis familiaris)
REACT:R-GGA-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Gallus gallus)
RHEA:60487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + UTP <=> cyclic CMP-UMP + 2 diphosphate
GO:0004140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dephosphocoenzyme A kinase activity
GO:0004140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dephosphocoenzyme A kinase (phosphorylating)
GO:0004140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dephospho-CoA kinase activity
GO:0004140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:dephospho-CoA 3'-phosphotransferase activity
GO:0004140	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-dephospho-CoA kinase activity
REACT:R-HSA-176298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of claspin (Homo sapiens)
RHEA:59956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkanimidothioate = a nitrile + sulfate + sulfur
RHEA:39436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)
GO:0018657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toluene 3-monooxygenase activity
RHEA:23786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + a quinol + H(+) => a quinone + L-proline
RHEA:49941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2
RHEA:28092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine
RHEA:59882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + FMN + H(+) + H2O => 4-hydroxyphenylacetate + FMNH2 + O2
REACT:R-XTR-1504213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Xenopus tropicalis)
REACT:R-BTA-1295613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds GRB2 (Bos taurus)
REACT:R-RNO-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Rattus norvegicus)
REACT:R-SSC-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Sus scrofa)
REACT:R-BTA-3781024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Bos taurus)
RHEA:56948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + UTP = H(+) + phosphoenolpyruvate + UDP
REACT:R-XTR-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Xenopus tropicalis)
RHEA:62384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2,3-bisphosphoglycerate + 2 H(+)
RHEA:62384	skos:prefLabel	"cyclic 2,3-diphosphoglycerate hydrolase"
RHEA:62384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclic 2,3-diphosphoglycerate hydrolase"
REACT:R-GGA-373748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD72 (Gallus gallus)
REACT:R-RNO-450422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP recruits RNA degradation activities (Rattus norvegicus)
REACT:R-SSC-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Sus scrofa)
REACT:R-CFA-5675373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)
REACT:R-HSA-389487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 2 receptor can bind orexin-B neuropeptide (Homo sapiens)
RHEA:51278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate
RHEA:39232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-triacontanoyl-CoA + H(+) + NADPH => (3R)-hydroxytriacontanoyl-CoA + NADP(+)
REACT:R-MMU-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Mus musculus)
RHEA:44044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
RHEA:58567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine + NADP(+) <=> 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH
GO:0034894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxypyridine-3-hydroxylase activity
REACT:R-CFA-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Canis familiaris)
REACT:R-BTA-917987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFRC dimer binds 2xholoTF (Bos taurus)
RHEA:25188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dichloroethane + H2O <=> 2-chloroethanol + chloride + H(+)
REACT:R-DRE-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Danio rerio)
REACT:R-SSC-8944230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Sus scrofa)
RHEA:10248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O = diphosphate + dUMP + H(+)
EC:7.2.2.3	skos:altLabel	"Na(+)-exporting ATPase"
EC:7.2.2.3	skos:altLabel	"Na(+)-transporting ATPase"
EC:7.2.2.3	skos:altLabel	"sodium transport ATPase"
EC:7.2.2.3	skos:altLabel	"sodium-exporting ATPase"
EC:7.2.2.3	skos:altLabel	"sodium-translocating P-type ATPase"
EC:7.2.2.3	skos:prefLabel	"P-type Na(+) transporter"
EC:7.2.2.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type Na(+) transporter"
REACT:R-DDI-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)
RHEA:68900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxybenzoate + ATP + H(+) + NADPH = 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)
REACT:R-XTR-139895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAK protein (Xenopus tropicalis)
REACT:R-DME-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Drosophila melanogaster)
RHEA:53899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)
RHEA:47184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-1474158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCHFR binds to GCH1 and negatively regulates its activity (Bos taurus)
RHEA:26046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-9-O-acetylneuraminate
GO:0050304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2O reductase activity
GO:0050304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrogen:(acceptor) oxidoreductase (N2O-forming)
GO:0050304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrous oxide reductase activity
GO:0050304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrous-oxide reductase activity
GO:0050304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrogen:acceptor oxidoreductase (N2O-forming)
REACT:R-HSA-9036056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HGSNAT does not acetylate Heparan sulfate chain(3) (Homo sapiens)
REACT:R-DRE-9603987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Danio rerio)
RHEA:30943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + octanoyl-CoA = (2E)-octenoyl-CoA + FADH2
RHEA:66238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + IC-asc-DeltaC9-CoA => IC-asc-C9-CoA + O2
RHEA:32711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(3R)-hydroxyacyl-CoA dehydrogenase"
RHEA:32711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH
RHEA:32711	skos:prefLabel	"(3R)-hydroxyacyl-CoA dehydrogenase"
REACT:R-XTR-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Xenopus tropicalis)
REACT:R-SCE-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Saccharomyces cerevisiae)
RHEA:56875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-acetyl-1-phenylethylamine + H2O <=> (S)-1-phenylethylamine + acetate
GO:0102796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protocatechualdehyde:oxygen oxidoreductase activity
RHEA:57231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-GDP
REACT:R-SSC-373791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Sus scrofa)
REACT:R-SSC-2201338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds TICAM1:activated TLR4 complex (Sus scrofa)
RHEA:13210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 3 H2O + trithionate => AH2 + 4 H(+) + 3 sulfite
RHEA:68300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + tetradecanoyl-CoA = CoA + O-tetradecanoyl-L-seryl-[protein]
REACT:R-DRE-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Danio rerio)
REACT:R-DME-9668904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18 complex (Drosophila melanogaster)
REACT:R-BTA-9605700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Bos taurus)
REACT:R-MMU-9684068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD binds cardiac glycosides (Mus musculus)
REACT:R-BTA-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Bos taurus)
REACT:R-RNO-9706319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA (Rattus norvegicus)
RHEA:59578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + N(pros)-methyl-L-histidine => anserine + H2O
REACT:R-DDI-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Dictyostelium discoideum)
REACT:R-DRE-174451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of DNA2 endonuclease to the C strand (Danio rerio)
REACT:R-RNO-909718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of p-STAT1 homodimer (Rattus norvegicus)
RHEA:17944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O
REACT:R-MMU-6799981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 binds bacterial peptidoglycan (Mus musculus)
RHEA:61285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cystine + O2 => (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)
EC:1.2.-.-	skos:prefLabel	"Acting on the aldehyde or oxo group of donors"
EC:1.2.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on the aldehyde or oxo group of donors"
REACT:R-RNO-9706364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of ubiquitinated FLT3 (Rattus norvegicus)
REACT:R-RNO-4341016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Rattus norvegicus)
RHEA:18219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-aminoaldehyde + L-glutamate => 2-oxoglutarate + an alkane-alpha,omega-diamine
RHEA:59466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + octadecanal => NADP(+) + octadecan-1-ol
REACT:R-SSC-1169398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host protein filamin B (Sus scrofa)
REACT:R-XTR-6806674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Xenopus tropicalis)
RHEA:34250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxymethyl-sphinganine + NADP(+) <=> 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH
EC:3.4.21.45	skos:altLabel	"complement component C3b inactivator"
EC:3.4.21.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"complement factor I"
EC:3.4.21.45	skos:altLabel	"C3b/C4b inactivator"
EC:3.4.21.45	skos:prefLabel	"complement factor I"
EC:3.4.21.45	skos:altLabel	"C3b inactivator"
RHEA:50700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:59369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)
REACT:R-SPO-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Schizosaccharomyces pombe)
REACT:R-SSC-2187332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic CMs translocate to extracellular region (Sus scrofa)
REACT:R-RNO-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Rattus norvegicus)
REACT:R-HSA-5229010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-27 of histone H3 (H3R26) (Homo sapiens)
RHEA:61544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:68392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + peracetic acid = acetate + H(+) + H2O2
REACT:R-RNO-444705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R1/T1R3 dimer is the umami taste receptor (Rattus norvegicus)
RHEA:38770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-BTA-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Bos taurus)
RHEA:66890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-174551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of alternative pathway C5 convertase (Canis familiaris)
REACT:R-MMU-139905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAD protein to mitochondria (Mus musculus)
REACT:R-HSA-450173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 induces oligomerisation of TRAF6 (Homo sapiens)
REACT:R-CFA-5218836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2beta binds alphaVbeta3 (Canis familiaris)
RHEA:46092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-HSA-9758868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown efflux pump transports glucuronidated PRED metabolite (Homo sapiens)
GO:0004865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein serine/threonine phosphatase inhibitor activity
REACT:R-DRE-9021357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCI phosphorylates ELF3 (Danio rerio)
REACT:R-CFA-983707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates at the activated BCR (Canis familiaris)
RHEA:33457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADPH + zymosterone => 4alpha-carboxyzymosterol + NADP(+)
REACT:R-CEL-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Caenorhabditis elegans)
RHEA:34753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => ATP + N-acyl-15-methylhexadecasphing-4-enine
REACT:R-XTR-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Xenopus tropicalis)
RHEA:70359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-3-oxosphinganine
REACT:R-HSA-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Homo sapiens)
REACT:R-SSC-9706293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CBL (Sus scrofa)
RHEA:54517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycopalyl diphosphate => (13R)-manoyl oxide + diphosphate
REACT:R-HSA-3301345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongator complex acetylates replicative histone H3, H4 (Homo sapiens)
RHEA:65209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA + H2O => (S)-3-hydroxybutanoate + CoA + H(+)
REACT:R-SSC-1605591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Sus scrofa)
RHEA:26350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-galactose 1-phosphate + H2O => L-galactose + phosphate
RHEA:12376	skos:prefLabel	"L-fuculokinase"
RHEA:12376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-fuculokinase"
RHEA:12376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-fuculose = ADP + H(+) + L-fuculose 1-phosphate
GO:0001761	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-alanine transporter activity
GO:0001761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine transmembrane transporter activity
REACT:R-XTR-5672954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Xenopus tropicalis)
RHEA:66174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-cystine(in) => H(+)(out) + L-cystine(out)
REACT:R-HSA-2972948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter (Homo sapiens)
RHEA:40560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-evernosamine + NADPH + O2 => dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)
RHEA:31304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a reduced flavin + NAD(+) => an oxidized flavin + 2 H(+) + NADH
REACT:R-SSC-5357904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Sus scrofa)
REACT:R-CEL-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Caenorhabditis elegans)
RHEA:45853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(II)-factor III + H(+) + S-adenosyl-L-methionine => Co(II)-factor IV + S-adenosyl-L-homocysteine
REACT:R-RNO-168166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
REACT:R-BTA-5688289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Bos taurus)
RHEA:69189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate
REACT:R-SSC-5686475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Sus scrofa)
REACT:R-HSA-141046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)
REACT:R-DRE-140355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS1 (Danio rerio)
REACT:R-RNO-2301205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 monomethylates histone H4 (Rattus norvegicus)
REACT:R-RNO-6784628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)
REACT:R-DME-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Drosophila melanogaster)
REACT:R-MMU-187020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of pro-beta-NGF is processed to mature beta-NGF (Mus musculus)
RHEA:45415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin D2-1-glycerol ester <=> glycerol + H(+) + prostaglandin D2
RHEA:27612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2 => formate + H(+)
REACT:R-BTA-5675431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates RAF1 (Bos taurus)
RHEA:18203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2
REACT:R-MMU-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Mus musculus)
REACT:R-MMU-451283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kainate receptor binds glutamate (Mus musculus)
REACT:R-GGA-6799466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 dimerizes (Gallus gallus)
RHEA:22909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP + H(+) + H2O => 3',5'-cyclic IMP + NH4(+)
REACT:R-DRE-6801808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A,REG3G binds bacterial peptidoglycan (Danio rerio)
REACT:R-SPO-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Schizosaccharomyces pombe)
GO:0050219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin-A1 delta-isomerase activity
GO:0050219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin-A1 D-isomerase activity
GO:0050219	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin A isomerase activity
GO:0050219	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity
RHEA:54711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-HSA-5333608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSSebGalNac is reduced and methylated to MeSebGalNac (Homo sapiens)
REACT:R-HSA-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Homo sapiens)
REACT:R-HSA-5657617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC (Homo sapiens)
RHEA:42170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-pregnan-3,20-dione + H(+) + NADPH => 20alpha-hydroxy-5beta-pregnan-3-one + NADP(+)
GO:0102657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADH-NADP-transhydrogenase
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADPH-NAD oxidoreductase
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H+-thase
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	energy-linked transhydrogenase
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nicotinamide adenine dinucleotide (phosphate) transhydrogenase
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD transhydrogenase
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)+ transhydrogenase activity
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADPH:NAD+ transhydrogenase
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyridine nucleotide transferase
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADH transhydrogenase
GO:0008746	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADPH-NAD transhydrogenase
GO:0034865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,4-trimethylpentanoate-CoA ligase activity
REACT:R-DRE-193656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with RIP2 (Danio rerio)
REACT:R-SSC-5682084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Sus scrofa)
REACT:R-HSA-9700190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK mutants bind SHC (Homo sapiens)
REACT:R-MMU-2046180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSPG is secreted from the cell (Mus musculus)
REACT:R-RNO-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Rattus norvegicus)
RHEA:24044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)
RHEA:24044	skos:altLabel	"protocatechuate 4,5-oxygenase"
RHEA:24044	skos:prefLabel	"protocatechuate 4,5-dioxygenase"
RHEA:24044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protocatechuate 4,5-dioxygenase"
RHEA:70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-alanine(in) + L-aspartate(out)
RHEA:41700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)
RHEA:62832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate
RHEA:52158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]
GO:0035173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity
RHEA:41808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O
RHEA:29714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine(in) + H(+)(in) <=> cadaverine(out) + H(+)(out)
RHEA:24686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formylmethanofuran = formate + methanofuran
RHEA:45906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + epivancomycin + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine
RHEA:35054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose(out) <=> N,N'-diacetylchitobiose(in)
GO:0080104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylthiopropyl glucosinolate S-oxygenase activity
RHEA:25190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetate + H2O => chloride + glycolate + H(+)
REACT:R-HSA-1364043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of PRLR (Homo sapiens)
GO:0102184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloartenol 4alpha-methyl oxidase activity
RHEA:24605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theobromine
RHEA:64812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + S-(2-aminoethyl)-homocysteine = CoA + H(+) + S-(2-acetamidoethyl)-homocysteine
RHEA:10649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 => 6-hydroxyhexan-6-olide + H2O + NADP(+)
RHEA:23755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-undecaprenol + ATP <=> ADP + all-trans-undecaprenyl phosphate + H(+)
REACT:R-GGA-1237059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ dehydrates HCO3- to CO2 (Gallus gallus)
RHEA:24260	skos:altLabel	"4-oxalocrotonate carboxy-lyase"
RHEA:24260	skos:prefLabel	"2-oxo-3-hexenedioate decarboxylase"
RHEA:24260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxo-3-hexenedioate decarboxylase"
RHEA:24260	skos:altLabel	"4-oxalocrotonate decarboxylase"
RHEA:24260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-2-oxohex-3-enedioate + H(+) = 2-oxopent-4-enoate + CO2
GO:0033902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA endonuclease activity
GO:0033902	skos:altLabel	"rRNA endonuclease"
GO:0033902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribotoxin"
GO:0033902	skos:prefLabel	"ribotoxin"
GO:0033902	skos:altLabel	"alpha-sarcin"
GO:0033902	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-sarcin
REACT:R-CFA-5223313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)
REACT:R-DRE-9033520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves TYSND1 (Danio rerio)
REACT:R-MMU-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Mus musculus)
RHEA:25430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate => ATP + N-acetyl-D-hexosamine
RHEA:36798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + 2 H2O <=> a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate
REACT:R-HSA-9755328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 8 binds class I MHC (Homo sapiens)
RHEA:17520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(long-chain-fatty-acyl)-L-glutamate <=> a long-chain fatty acid + L-glutamate
RHEA:15434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + dimethylallyl diphosphate => diphosphate + sophoraflavanone B
RHEA:34723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine 1-phosphate + H2O = 15-methylhexadecasphing-4-enine + phosphate
GO:0004552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-octanol dehydrogenase activity
GO:0004552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	octanol:NAD+ oxidoreductase activity
GO:0004552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanol dehydrogenase activity
RHEA:36995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA
REACT:R-DDI-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Dictyostelium discoideum)
RHEA:44974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-hexanoyl-(R)-carnitine => (R)-carnitine + hexanoyl-CoA
REACT:R-BTA-9630923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
REACT:R-DME-166214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion flip-flops to the opposite surface (Drosophila melanogaster)
REACT:R-MMU-76373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxylation of 4-aminobiphenyl (Mus musculus)
RHEA:55447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine => L-glutaminyl-[protein] + S-adenosyl-L-methionine
REACT:R-SSC-6784189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind LIFR (Sus scrofa)
REACT:R-SPO-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
REACT:R-XTR-2160931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of tight junctions (Xenopus tropicalis)
GO:0045127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-acetylamino-2-deoxy-D-glucose kinase activity
GO:0045127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylaminodeoxyglucokinase activity
GO:0045127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity
GO:0045127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglucosamine kinase (phosphorylating)
GO:0045127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate
GO:0045127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity
GO:0045127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosamine kinase"
GO:0045127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine kinase activity
GO:0045127	skos:altLabel	"GlcNAc kinase"
GO:0045127	skos:prefLabel	"N-acetylglucosamine kinase"
GO:0045127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcNAc kinase activity
REACT:R-XTR-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Xenopus tropicalis)
REACT:R-BTA-9603984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Bos taurus)
REACT:R-DDI-390252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Dictyostelium discoideum)
REACT:R-HSA-5340195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4 binds DCA, CDCA, LCHA (Homo sapiens)
RHEA:20637	skos:prefLabel	"glucose-fructose oxidoreductase"
RHEA:20637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol
RHEA:20637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-fructose oxidoreductase"
REACT:R-CEL-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Caenorhabditis elegans)
REACT:R-HSA-2473596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP15 (Homo sapiens)
RHEA:63260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH = 4-pyridoxate + NAD(+)
GO:0047238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin synthase activity
GO:0047238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0047238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosaminyltransferase II activity
GO:0047238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0047238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity
GO:0047238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity
GO:0047238	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity
GO:0047238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
REACT:R-BTA-5577234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Bos taurus)
GO:0050518	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity
GO:0050518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO:0050518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEP cytidylyltransferase activity
GO:0050518	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MCT activity
GO:0050518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity
GO:0050518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
REACT:R-BTA-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Bos taurus)
RHEA:72625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base
REACT:R-MMU-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Mus musculus)
REACT:R-CFA-8932355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades Ub-NFE2L2 (Canis familiaris)
REACT:R-BTA-202459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Bcl10 (Bos taurus)
GO:0072371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-serine kinase activity (H2A-S121 specific)
GO:0072371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A-S121 kinase activity
GO:0072371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H2A-S121 specific)
GO:0072371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AS121 kinase activity
GO:0072371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serine kinase activity (H2A-S121 specific)
RHEA:62133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + dTTP => a 2'-deoxyribonucleoside 5'-diphosphate + dTDP
RHEA:38120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol => 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
GO:0033871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-OST-2
GO:0033871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosaminyl 3-O-sulfotransferase 2 activity
GO:0033871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoform/isozyme 2 (3-OST-2, HS3ST2)
GO:0033871	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glucosaminyl 3-O-sulfotransferase activity
GO:0033871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity
GO:0033871	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity
GO:0033871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin-glucosamine 3-sulfotransferase 2 activity
GO:0033871	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity
GO:0033871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity
REACT:R-CFA-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Canis familiaris)
RHEA:29618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltotriose + beta-maltose <=> alpha-maltotetraose + beta-D-glucose
REACT:R-MMU-141202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates TYR (Mus musculus)
RHEA:69314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl thiocyanate + sulfate => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate
REACT:R-CFA-4093336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
REACT:R-XTR-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)
REACT:R-RNO-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Rattus norvegicus)
REACT:R-HSA-9712210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Homo sapiens)
RHEA:17733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylenedicarboxylate + H(+) + H2O = CO2 + pyruvate
RHEA:17733	skos:altLabel	"acetylenedicarboxylate hydratase"
RHEA:17733	skos:prefLabel	"acetylenedicarboxylate decarboxylase"
RHEA:17733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylenedicarboxylate decarboxylase"
RHEA:17733	skos:altLabel	"acetylenedicarboxylate carboxy-lyase"
RHEA:24845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O => 2 isomaltose
REACT:R-HSA-1655839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Phosphomevalonate Kinase (PMVK) (Homo sapiens)
REACT:R-DRE-9629195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Danio rerio)
RHEA:59988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1-carbonyl-CoA + NADP(+) = cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH
REACT:R-SSC-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Sus scrofa)
RHEA:21364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(6-aminohexanoyl)-6-aminohexanoate = 2 6-aminohexanoate
RHEA:35834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + kanamycin B + O2 <=> 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate
REACT:R-BTA-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Bos taurus)
RHEA:10434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CO2 + NH4(+) + succinate semialdehyde => 2-(acetamidomethylene)succinate + H(+) + 2 H2O
RHEA:18420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM3 (d18:1(4E)) + H(+)
REACT:R-XTR-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Xenopus tropicalis)
REACT:R-XTR-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Xenopus tropicalis)
RHEA:24301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(I)yrinate a,c diamide + FMN + 3 H(+) => 2 cob(II)yrinate a,c diamide + FMNH2
REACT:R-GGA-199935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates CREB (Gallus gallus)
RHEA:51024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene-4-sulfonate = 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)
RHEA:28045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + pyruvate <=> acetyl-CoA + CO2 + NADH
REACT:R-SSC-2984220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1:CCNB phosphorylates NEK9 (Sus scrofa)
REACT:R-CFA-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Canis familiaris)
RHEA:35143	skos:prefLabel	"2,4,6-trihydroxybenzophenone synthase"
RHEA:35143	skos:altLabel	"benzophenone synthase"
RHEA:35143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA
RHEA:35143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4,6-trihydroxybenzophenone synthase"
REACT:R-CFA-8848335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37 binds  IL18R1 (Canis familiaris)
REACT:R-DRE-76496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Danio rerio)
REACT:R-XTR-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Xenopus tropicalis)
RHEA:36928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA
RHEA:40391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA = 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA
RHEA:40615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tridecanoylglycerol = 2,3-didecanoyl-sn-glycerol + decanoate + H(+)
REACT:R-BTA-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Bos taurus)
REACT:R-CFA-141040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Canis familiaris)
REACT:R-CFA-9021609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR-associated SRC autophosphorylates (Canis familiaris)
EC:3.1.26.13	skos:prefLabel	"retroviral ribonuclease H"
EC:3.1.26.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"retroviral ribonuclease H"
RHEA:42580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)
GO:1990829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-rich ssDNA binding
GO:1990829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-rich single-stranded DNA binding
REACT:R-SSC-5682769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI2 binds ADAM22,23 (Sus scrofa)
REACT:R-RNO-1592316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP1 (Rattus norvegicus)
REACT:R-DME-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Drosophila melanogaster)
REACT:R-SSC-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Sus scrofa)
REACT:R-MMU-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Mus musculus)
REACT:R-DRE-8987084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Danio rerio)
REACT:R-HSA-1222722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mycobactin is exported (Homo sapiens)
REACT:R-MMU-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Mus musculus)
REACT:R-XTR-1474197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP1,3,8,13,PRSS2 (Xenopus tropicalis)
RHEA:50723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + methanesulfinate + O2 <=> FMN + H(+) + H2O + methanesulfonate
GO:0005272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Homo sapiens)
GO:0005272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPM4,5 transport extracellular Na+ to cytosol (Homo sapiens)
GO:0005272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium channel activity
GO:0102911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-secoisolariciresinol dehydrogenase activity
REACT:R-CFA-8952716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 binds Ragulator:Rag dimers (Canis familiaris)
REACT:R-HSA-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Homo sapiens)
REACT:R-CEL-9008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 phosphorylates RUNX2 (Caenorhabditis elegans)
RHEA:31786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tuberculosinyl diphosphate <=> diphosphate + tuberculosinol
RHEA:66423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)
REACT:R-HSA-5250962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botG LC cleaves target cell VAMP2 (Homo sapiens)
REACT:R-BTA-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Bos taurus)
RHEA:41363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-DME-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)
REACT:R-CFA-8944254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVI (Canis familiaris)
REACT:R-DRE-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Danio rerio)
RHEA:19521	skos:prefLabel	"phosphate acetyltransferase"
RHEA:19521	skos:altLabel	"phosphoacylase"
RHEA:19521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphate acetyltransferase"
RHEA:19521	skos:altLabel	"phosphotransacetylase"
RHEA:19521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + phosphate = acetyl phosphate + CoA
RHEA:62053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)
RHEA:13614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + diphosphate => beta-D-fructose 1,6-bisphosphate + H(+) + phosphate
REACT:R-SPO-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Schizosaccharomyces pombe)
REACT:R-CFA-2130282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated beta catenin by the proteasome (Canis familiaris)
REACT:R-BTA-72130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of an intermediate Spliceosomal C complex (Bos taurus)
GO:0031839	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 neuromedin U receptor ligand
GO:0031839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 neuromedin U receptor binding
RHEA:19336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxalyl-CoA <=> CO2 + formyl-CoA
RHEA:71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-cysteine(in) + Na(+)(in) => H(+)(in) + L-cysteine(out) + Na(+)(out)
RHEA:34622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxypentalenate + 2-oxoglutarate + O2 <=> 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate
RHEA:25702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-380278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Drosophila melanogaster)
REACT:R-CEL-2514831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP14 (Caenorhabditis elegans)
RHEA:53556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-4088298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXM1 stimulates CCNB1 transcription (Homo sapiens)
REACT:R-DME-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Drosophila melanogaster)
GO:1904047	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	radical SAM enzyme activity
GO:1904047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Homo sapiens)
GO:1904047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine binding
REACT:R-BTA-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Bos taurus)
GO:0047108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxyacid-ester dehydrogenase activity
GO:0047108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxyacid ester dehydrogenase activity
GO:0047108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity
GO:0047108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo ester (R)-reductase activity
REACT:R-RNO-3697894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN2 (Rattus norvegicus)
RHEA:11346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CMP-N-acyl-beta-neuraminate + diphosphate => an N-acylneuraminate + CTP
REACT:R-SSC-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Sus scrofa)
REACT:R-MMU-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Mus musculus)
RHEA:49845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid + a quinone => (-)-dehydrodiconiferyl acid ketone + a quinol
RHEA:61288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-ribose + ATP = 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)
RHEA:25290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD(+) = acetaldehyde + H(+) + NADH
REACT:R-GGA-8857928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIHBP1 binds HSPG:LPL dimer (Gallus gallus)
RHEA:46832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-RNO-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Rattus norvegicus)
REACT:R-SSC-8869633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NR to yield NMN (Sus scrofa)
REACT:R-DME-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)
REACT:R-MMU-2065550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds Importin beta-1 (Mus musculus)
RHEA:62238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine dimer in DNA + H(+) => a cytidine(6-4)cytidine in DNA
RHEA:31553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + diphosphate => presqualene diphosphate
RHEA:41666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chelirubine + NADH => dihydrochelirubine + NAD(+)
RHEA:14054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose 5-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate
REACT:R-PFA-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Plasmodium falciparum)
RHEA:54873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-menthone + H(+) + NADPH + O2 => (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)
REACT:R-DRE-389622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Danio rerio)
REACT:R-DRE-983422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of COPII coated vesicle (Danio rerio)
REACT:R-DDI-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Dictyostelium discoideum)
REACT:R-DDI-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Dictyostelium discoideum)
REACT:R-RNO-141040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Rattus norvegicus)
REACT:R-RNO-3296309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR3 binds HCAR3 ligands (Rattus norvegicus)
RHEA:25435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-ribopyranose <=> beta-D-ribofuranose
REACT:R-CFA-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Canis familiaris)
GO:1990028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	R-type calcium channel
GO:1990028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intermediate voltage-gated calcium channel activity
REACT:R-RNO-76434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of carbon tetrachloride to form a free radical (Rattus norvegicus)
RHEA:16283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+) => ATP + dihydrostreptomycin 6-phosphate
RHEA:38690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine(in) + ATP + H2O <=> (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate
RHEA:37428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-XTR-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)
REACT:R-BTA-211178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO1A is excluded from the nucleus (Bos taurus)
RHEA:55818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine => a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine
GO:0046875	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ephrin
GO:0046875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ephrin receptor binding
GO:0046875	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transmembrane ephrin
GO:0046875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Eph receptor binding
GO:0046875	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GPI-linked ephrin
REACT:R-CFA-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)
RHEA:34727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphinganine = 15-methylhexadecasphinganine + a carboxylate
RHEA:61890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diosgenin 3-O-beta-D-glucoside + H(+) + UDP => diosgenin + UDP-alpha-D-glucose
REACT:R-SSC-3249371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylates STAT6 at Ser407 (Sus scrofa)
REACT:R-DRE-9013022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GAPs stimulate RHOB GTPase activity (Danio rerio)
REACT:R-HSA-9623999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL gene expression downstream of ESR1 (Homo sapiens)
RHEA:36019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:67585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-HSA-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Homo sapiens)
RHEA:48538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+) => 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O
RHEA:11253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydroxylamine + L-asparagine => beta-L-aspartylhydroxamate + NH4(+)
RHEA:29670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O(in) <=> H2O(out)
RHEA:54952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + nonanoate = AMP + diphosphate + nonanoyl-CoA
GO:0050514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)
GO:0050514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homospermidine synthase (spermidine-specific) activity
RHEA:62516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP
REACT:R-HSA-5612508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R binds the PTCH1 promoter (Homo sapiens)
REACT:R-GGA-187632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea (Gallus gallus)
RHEA:10088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + UDP-alpha-D-galactose = 6(F)-alpha-D-galactosylsucrose + H(+) + UDP
RHEA:10088	skos:prefLabel	"sucrose 6(F)-alpha-galactosyltransferase"
RHEA:10088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sucrose 6(F)-alpha-galactosyltransferase"
GO:0016862	skos:prefLabel	"Interconverting keto- and enol-groups"
GO:0016862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Interconverting keto- and enol-groups"
GO:0016862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular isomerase activity, interconverting keto- and enol-groups
GO:0016862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular oxidoreductase activity, interconverting keto- and enol-groups
REACT:R-PFA-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Plasmodium falciparum)
REACT:R-HSA-70859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Homo sapiens)
RHEA:20067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2
REACT:R-SSC-159761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Sus scrofa)
REACT:R-MMU-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Mus musculus)
RHEA:24863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP => pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose
REACT:R-SSC-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Sus scrofa)
GO:0016159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	muconolactone isomerase activity
GO:0016159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	muconolactone D-isomerase activity
GO:0016159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	muconolactone delta-isomerase activity
GO:0016159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity
REACT:R-RNO-210291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Rattus norvegicus)
RHEA:22599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cephalosporin C + H2O <=> acetate + deacetylcephalosporin C + H(+)
RHEA:53434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose
RHEA:52754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + D-glucose => H2O + isomaltose
RHEA:16759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + trypanothione disulfide => NADP(+) + trypanothione
RHEA:72960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) => (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)
EC:2.1.1.63	skos:prefLabel	"methylated-DNA--[protein]-cysteine S-methyltransferase"
EC:2.1.1.63	skos:altLabel	"O-6-methylguanine-DNA-alkyltransferase"
EC:2.1.1.63	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylated-DNA--[protein]-cysteine S-methyltransferase"
EC:2.1.1.63	skos:altLabel	"6-O-methylguanine-DNA methyltransferase"
REACT:R-GGA-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Gallus gallus)
REACT:R-HSA-381537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)
REACT:R-DDI-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Dictyostelium discoideum)
REACT:R-HSA-9706308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRB10 (Homo sapiens)
RHEA:26003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol 1-phosphate + NAD(+) => D-xylulose 5-phosphate + H(+) + NADH
REACT:R-SSC-5620921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Sus scrofa)
RHEA:67250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enoate + 2 H(+) + NADH => (E)-4-hydroxynon-2-enal + H2O + NAD(+)
REACT:R-DRE-5662606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds zinc (Danio rerio)
RHEA:61925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4R)-ketoconazole(in) + ATP + H2O => (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate
RHEA:19852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) <=> ADP-D-ribose 2'-phosphate + H(+) + nicotinamide
REACT:R-MMU-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Mus musculus)
GO:0051537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 iron, 2 sulphur cluster binding
GO:0051537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diiron disulfide cluster binding
GO:0051537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diiron disulphide cluster binding
GO:0051537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulphur cluster 2Fe-2S binding
GO:0051537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 iron, 2 sulfur cluster binding
GO:0051537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulfur cluster 2Fe-2S binding
GO:0051537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2Fe-2S cluster binding
GO:0051537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe 2 S cluster binding
RHEA:57916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartyl-tRNA(Asn) = 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)
RHEA:31404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) => all-trans-4,4'-diaponeurosporene + FADH2
REACT:R-DDI-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Dictyostelium discoideum)
REACT:R-HSA-2328037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds integrins (Homo sapiens)
REACT:R-XTR-9661408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Xenopus tropicalis)
RHEA:47800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-methionine
RHEA:43657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)
REACT:R-DRE-211923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26C1 4-hydroxylates 9cRA (Danio rerio)
RHEA:69844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in RNA + NAD(+) => a uridine in RNA + H(+) + NADH
REACT:R-HSA-193643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDM4 (SC1) binds to p75NTR (Homo sapiens)
RHEA:29468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + K(+)(in) => H(+)(in) + K(+)(out)
RHEA:45718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glycine betaine + H(+) => H2O + N,N,N-trimethylglycyl-CoA
RHEA:21187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + GDP-alpha-D-mannose <=> a dolichyl beta-D-mannosyl phosphate + GDP
RHEA:10134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + benzoyl-CoA + diphosphate => ATP + benzoate + CoA
REACT:R-XTR-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Xenopus tropicalis)
REACT:R-MMU-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Mus musculus)
RHEA:61183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucoside + UDP
REACT:R-RNO-444047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR3 binds carboxylates (Rattus norvegicus)
REACT:R-RNO-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Rattus norvegicus)
RHEA:27588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + L-alanine => L-tryptophan + pyruvate
GO:0034918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity
RHEA:59685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaose + O2 => D-maltohexaono-1,5-lactone + H2O2
GO:0035248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,4-N-acetylgalactosaminyltransferase activity
GO:0035248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,4-GalNAc transferase activity
REACT:R-HSA-9694364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-glycan glucose trimming of Spike (Homo sapiens)
REACT:R-SSC-9032798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK3 activates RAC1 (Sus scrofa)
REACT:R-DDI-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Dictyostelium discoideum)
RHEA:72228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + sarcosine(out) => chloride(in) + 2 Na(+)(in) + sarcosine(in)
REACT:R-CFA-9009936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEL cleaves cellular ssRNA (Canis familiaris)
REACT:R-RNO-5676593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Rattus norvegicus)
RHEA:48418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GM2 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E))
REACT:R-DME-9647977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT methylates S-Farn RAS proteins (Drosophila melanogaster)
REACT:R-CFA-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Canis familiaris)
RHEA:15413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate = H2O + oxaloacetate
RHEA:15413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L(+)-tartrate dehydratase"
RHEA:15413	skos:prefLabel	"L(+)-tartrate dehydratase"
REACT:R-SSC-1497853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Sus scrofa)
RHEA:23110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinonate + H(+) => D-arabinono-1,4-lactone + H2O
RHEA:58885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 => A + chloramphenicol + 2 H2O
RHEA:20395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP] => holo-[citrate lyase ACP] + S-acetylphosphopantotheine
REACT:R-SSC-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
REACT:R-HSA-9672176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the mutant PDGFRA receptor (Homo sapiens)
REACT:R-DRE-8851890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates SHC1-2 (Danio rerio)
RHEA:16042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-beta-D-glucosyl](n) + phosphate => [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
RHEA:29496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => beta-eudesmol + diphosphate
REACT:R-GGA-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Gallus gallus)
EC:3.2.1.101	skos:altLabel	"1,6-beta-D-mannan mannanohydrolase"
EC:3.2.1.101	skos:altLabel	"endo-alpha-1->6-D-mannanase"
EC:3.2.1.101	skos:prefLabel	"mannan endo-1,6-alpha-mannosidase"
EC:3.2.1.101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannan endo-1,6-alpha-mannosidase"
EC:3.2.1.101	skos:altLabel	"endo-1,6-beta-mannanase"
RHEA:52644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate + H(+)
GO:0003724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA helicase activity
GO:0003724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent RNA helicase activity
REACT:R-HSA-388981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Kiss receptor GPR54 binds kisspeptin (Homo sapiens)
REACT:R-SSC-202709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 dimerises (Sus scrofa)
REACT:R-CEL-2002440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen C-propeptides (Caenorhabditis elegans)
REACT:R-MMU-4085028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE phosphorylates ManNAc to ManNAc-6-P (Mus musculus)
REACT:R-SSC-3341397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
RHEA:10683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline <=> D-proline
REACT:R-DRE-419351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF receptor binds platelet activating factor (Danio rerio)
RHEA:16768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + NADP(+) <=> D-fructose + H(+) + NADPH
GO:0016415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanoyltransferase activity
RHEA:50029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine
RHEA:56162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP => an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate
REACT:R-BTA-156526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)
REACT:R-MMU-2130378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex to plasma membrane (Mus musculus)
RHEA:38915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)
REACT:R-XTR-446130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 2 binds Interleukin 1 (Xenopus tropicalis)
RHEA:59093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n) + sucrose => [(1->3)-alpha-D-glucosyl](n+1) + D-fructose
REACT:R-MMU-199579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR2DL4 interacting with HLA-G (Mus musculus)
GO:0009905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ent-kaurene synthase A activity
GO:0009905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ent-kaurene synthetase A activity
GO:0009905	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	diterpene cyclase activity
GO:0009905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate synthase activity
GO:0009905	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ent-copalyl-diphosphate lyase (decyclizing)
RHEA:63198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10bR,4aS)-oxomaritidine + NADP(+) => (10bR,4aS)-noroxomaritidine + H(+) + NADPH
REACT:R-HSA-8871373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMX phosphorylates RUFY1 (Homo sapiens)
RHEA:41640	skos:prefLabel	"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate--CoA ligase"
RHEA:41640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate--CoA ligase"
RHEA:41640	skos:altLabel	"HIP--CoA ligase"
RHEA:41640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
REACT:R-BTA-110350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of TDG glycosylase by APEX1 at the AP site (Bos taurus)
REACT:R-CFA-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Canis familiaris)
REACT:R-HSA-71335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Homo sapiens)
REACT:R-MMU-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Mus musculus)
REACT:R-MMU-8950485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Mus musculus)
REACT:R-SCE-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Saccharomyces cerevisiae)
REACT:R-MMU-429581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 transports vitamins from extracellular region to cytosol (Mus musculus)
RHEA:30185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-tagaturonate + NADH => L-galactonate + NAD(+)
REACT:R-SSC-5615637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Sus scrofa)
EC:2.7.11.28	skos:altLabel	"tropomyosin kinase (phosphorylating)"
EC:2.7.11.28	skos:prefLabel	"tropomyosin kinase"
EC:2.7.11.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tropomyosin kinase"
GO:0015322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligopeptide porter activity
GO:0015322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secondary active oligopeptide transmembrane transporter activity
RHEA:55271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate <=> (R)-glycerate + alpha-D-glucose 1-phosphate
REACT:R-HSA-209087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBA is phosphorylated by Phospho IKKB kinase (Homo sapiens)
RHEA:62164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O = D-glucosamine + N-acetyl-D-glucosamine
REACT:R-BTA-420214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The adrenomedullin receptor can bind adrenomedullin and intermedin (Bos taurus)
RHEA:41422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + grixazone B + 4 H2O => 2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2
GO:0015247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminophospholipid transporter activity
GO:0015247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminophospholipid flippase activity
GO:0015247	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminophospholipid transmembrane transporter activity
RHEA:34614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose <=> H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP
RHEA:43728	skos:altLabel	"CYP15A1"
RHEA:43728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methyl farnesoate epoxidase"
RHEA:43728	skos:prefLabel	"methyl farnesoate epoxidase"
RHEA:43728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Danio rerio)
REACT:R-SSC-209772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to triiodothyronine (Sus scrofa)
REACT:R-BTA-5205820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)
RHEA:16462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + urate(in) => ADP + H(+) + phosphate + urate(out)
RHEA:25730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]
GO:0047145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-methyltransferase I
GO:0047145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylsterigmatocystin 6-O-methyltransferase activity
GO:0047145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	demethylsterigmatocystin methyltransferase activity
GO:0047145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity
REACT:R-SSC-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Sus scrofa)
REACT:R-GGA-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Gallus gallus)
GO:0047919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-mannose 6-dehydrogenase activity
GO:0047919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPmannose 6-dehydrogenase activity
GO:0047919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose dehydrogenase activity
GO:0047919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP mannose dehydrogenase activity
GO:0047919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-D-mannose:NAD+ 6-oxidoreductase activity
GO:0047919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphospho-D-mannose dehydrogenase activity
REACT:R-HSA-1306953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
REACT:R-SCE-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Saccharomyces cerevisiae)
GO:1901241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate(in) = 4-hydroxyphenylacetate(out)
GO:1901241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate transmembrane transporter activity
RHEA:71963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)
RHEA:16379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:52033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + L-isoleucine
REACT:R-RNO-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Rattus norvegicus)
RHEA:18940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-homoserine lactone + H2O <=> a carboxylate + L-homoserine lactone
REACT:R-PFA-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Plasmodium falciparum)
RHEA:32866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-190265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds to FGF (Rattus norvegicus)
RHEA:45113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol + H(+) + NADPH + O2 => 13-hydroxy-gamma-tocopherol + H2O + NADP(+)
REACT:R-MMU-139917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAX protein (Mus musculus)
RHEA:45446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
GO:0052866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol phosphate phosphatase activity
GO:0052866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoinositide phosphatase activity
REACT:R-XTR-5654159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds PLCG1 (Xenopus tropicalis)
REACT:R-HSA-9006490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the GRIN2A gene promoter (Homo sapiens)
RHEA:71651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine in DNA + NAD(+) = an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide
RHEA:35131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-glutamate(out) = H(+)(in) + L-alanyl-L-glutamate(in)
REACT:R-CFA-110364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Canis familiaris)
RHEA:48476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1a (d18:1(4E)) + H2O = ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate
RHEA:72056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate(out) + 2 Na(+)(out) => glycodeoxycholate(in) + 2 Na(+)(in)
REACT:R-MMU-419490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATP to P2X receptors (Mus musculus)
REACT:R-CFA-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Canis familiaris)
REACT:R-RNO-5654565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Rattus norvegicus)
REACT:R-DRE-352385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Danio rerio)
RHEA:36134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine
RHEA:29917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose
REACT:R-XTR-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Xenopus tropicalis)
RHEA:28338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"crotonobetainyl-CoA hydratase"
RHEA:28338	skos:altLabel	"L-carnitinyl-CoA dehydratase"
RHEA:28338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinyl-CoA = crotonobetainyl-CoA + H2O
RHEA:28338	skos:prefLabel	"crotonobetainyl-CoA hydratase"
RHEA:15168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + sarcosine <=> glyoxylate + H2O2 + methylamine
REACT:R-MMU-879910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 is phosphorylated, activated (Mus musculus)
RHEA:25062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH
RHEA:45073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-191790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading and methylation of Sm proteins onto SMN Complexes (Sus scrofa)
RHEA:64548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] = (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]
REACT:R-HSA-193995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 18-hydroxylates CORST to 18HCORST (Homo sapiens)
REACT:R-RNO-469659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A1 dehydrogenates TEST to DHTEST (Rattus norvegicus)
RHEA:37134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-CFA-9021306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds and inactivates C1r, C1s (Canis familiaris)
REACT:R-RNO-174446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap from the C-strand (Rattus norvegicus)
REACT:R-BTA-934604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
REACT:R-SSC-5672954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Sus scrofa)
REACT:R-HSA-9023980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18(S)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)
REACT:R-DRE-1222376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide from oxygen (Danio rerio)
RHEA:11016	skos:altLabel	"allantoate amidinohydrolase"
RHEA:11016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + H2O = (S)-ureidoglycolate + urea
RHEA:11016	skos:prefLabel	"allantoicase"
RHEA:11016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"allantoicase"
REACT:R-BTA-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Bos taurus)
RHEA:39733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-77309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Homo sapiens)
REACT:R-DME-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Drosophila melanogaster)
RHEA:49766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O => ethylenediaminetriacetate + FMNH2 + O2
REACT:R-DME-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Drosophila melanogaster)
RHEA:14831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-cysteine => hydrogen sulfide + O-acetyl-L-serine
RHEA:70565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+)
RHEA:33635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + docosanoate = AMP + diphosphate + docosanoyl-CoA
RHEA:65470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + propyl acetate => 1-propanol + acetyl-CoA
REACT:R-MMU-265423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Fibrillin (Mus musculus)
REACT:R-MMU-3858495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits GTP-bound RHOA (Mus musculus)
GO:0019103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine nucleotide binding
RHEA:64519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate + NAD(+) <=> H(+) + NADH + sulfoacetaldehyde
REACT:R-CEL-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Caenorhabditis elegans)
RHEA:42445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NADP(+) => H(+) + iminosuccinate + NADPH
RHEA:60279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine
REACT:R-CFA-5693539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of DNA and formation of Holliday structures following repair synthesis (Canis familiaris)
REACT:R-HSA-5610718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI2 (Homo sapiens)
REACT:R-BTA-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Bos taurus)
REACT:R-XTR-8853745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA3 (Xenopus tropicalis)
REACT:R-XTR-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Xenopus tropicalis)
RHEA:35241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracycline(out) => tetracycline(in)
RHEA:51429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + aminomethylphosphonate => 2-N-acetamidomethylphosphonate + CoA
REACT:R-RNO-83582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Rattus norvegicus)
REACT:R-SSC-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Sus scrofa)
RHEA:67563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + taurocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate
REACT:R-MMU-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Mus musculus)
RHEA:34499	skos:altLabel	"CYP105D7"
RHEA:34499	skos:prefLabel	"pentalenic acid synthase"
RHEA:34499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pentalenic acid synthase"
RHEA:34499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] = H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate
REACT:R-HSA-8849094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RASA1 (Homo sapiens)
REACT:R-HSA-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Homo sapiens)
RHEA:63411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-chloropyridine-2,3,5-triol + FADH2 + O2 <=> 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O
RHEA:40394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA <=> 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA
REACT:R-GGA-1369052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid influx (Gallus gallus)
RHEA:60567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose + ATP <=> 2-deoxy-D-glucose 6-phosphate + ADP + H(+)
REACT:R-DRE-5138433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Danio rerio)
REACT:R-RNO-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Rattus norvegicus)
REACT:R-SCE-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Saccharomyces cerevisiae)
GO:0008263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0008263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G/T-mismatch-specific thymine-DNA glycosylase activity
RHEA:11810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bergapten + S-adenosyl-L-homocysteine => bergaptol + S-adenosyl-L-methionine
RHEA:42218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)
GO:0099626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
RHEA:55667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + echinenone + 2 O2 <=> 2 A + canthaxanthin + 3 H2O
REACT:R-HSA-9666435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK (Homo sapiens)
REACT:R-MMU-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Mus musculus)
REACT:R-GGA-140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Gallus gallus)
REACT:R-MMU-5696230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO1 dimer reduces methylarsonate to methylarsonite (Mus musculus)
RHEA:43670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate => ATP + hexacosanoyl-CoA + hydrogencarbonate
REACT:R-DRE-1433418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Danio rerio)
RHEA:37425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin A + H2O2 => aclacinomycin N + O2
RHEA:23217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + H(+) + NADPH + O2 => 3-hydroxybenzoyl-CoA + H2O + NADP(+)
REACT:R-GGA-434030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex (Gallus gallus)
REACT:R-SSC-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Sus scrofa)
REACT:R-HSA-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Homo sapiens)
RHEA:29837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactonate(out) + H(+)(out) => D-galactonate(in) + H(+)(in)
RHEA:51223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-2,4-dinitrobenzene + glutathione <=> 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
REACT:R-HSA-6790944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447 (Homo sapiens)
RHEA:60059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)
GO:1990206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonyl-Ile conjugate hydrolase activity
GO:1990206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	JA-Ile hydrolase
REACT:R-MMU-377643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
GO:0036055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-succinyllysine desuccinylase activity
GO:0036055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-succinyllysine desuccinylase activity
GO:0036055	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinyl lysine desuccinylase activity
GO:0036055	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinyllysine desuccinylase activity
GO:0036055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-HSA-8871506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORL1 transports APP(18-770) from endosome lumen to Golgi lumen (Homo sapiens)
REACT:R-HSA-211467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF1A-dependent synthesis of HNF4G protein (Homo sapiens)
REACT:R-GGA-9013284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3-ligand complex is cleaved to produce NEXT3 (Gallus gallus)
REACT:R-SPO-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Schizosaccharomyces pombe)
GO:0106430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroorotate dehydrogenase (quinone) activity
RHEA:37914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA
RHEA:19539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + phosphate => D-mannitol 1-phosphate + H2O
RHEA:32788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-ectoine(out) => ADP + H(+) + L-ectoine(in) + phosphate
REACT:R-RNO-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Rattus norvegicus)
REACT:R-BTA-5649711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 incises DNA strand 5' to the AP site (Bos taurus)
RHEA:23878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + xanthoaphin => protoaphin aglucone
EC:3.2.1.178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-porphyranase"
EC:3.2.1.178	skos:altLabel	"endo-beta-porphyranase"
EC:3.2.1.178	skos:prefLabel	"beta-porphyranase"
EC:3.2.1.178	skos:altLabel	"porphyranase"
REACT:R-DME-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Drosophila melanogaster)
REACT:R-DRE-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Danio rerio)
RHEA:50358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+) => 4-hydroxy-6-methylpretetramide + NADPH + O2
REACT:R-CFA-8950405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Canis familiaris)
REACT:R-SSC-2065539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:Importin beta-1 dissociates (Sus scrofa)
RHEA:30701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + L-glutamate => 2-oxoglutarate + beta-alanine
RHEA:48499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP
REACT:R-HSA-8935980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the OCLN gene promoter (Homo sapiens)
GO:0016647	skos:prefLabel	"With oxygen as acceptor"
GO:0016647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
GO:0016647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
REACT:R-HSA-9710294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD expression mediated by IRF2, IRF1 (Homo sapiens)
RHEA:25734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-tetrahomomethionine <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O
REACT:R-DDI-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Dictyostelium discoideum)
RHEA:49219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate
RHEA:45439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate
REACT:R-MMU-9708466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y486 BACH1 translocates from the nucleoplasm to the cytosol (Mus musculus)
REACT:R-RNO-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
GO:0102421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity
RHEA:51332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 = 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate
RHEA:54037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) => [mycoredoxin]-S-mycothiol-L-cysteine + arsenite
REACT:R-HSA-2028692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK4 (p-MST1) by caspase 3 (Homo sapiens)
REACT:R-HSA-112333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC autophosphorylation is positively regulated by InlA-bound CDH1 (Homo sapiens)
RHEA:59898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate => ATP + L-glutamate + L-propargylglycine
REACT:R-CFA-9755303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades HIFalpha (Canis familiaris)
REACT:R-MMU-8983307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL15RA (Mus musculus)
RHEA:37350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + ATP + D-alanine <=> ADP + D-alanyl-(R)-lactate + phosphate
RHEA:57218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glyoxal
REACT:R-MMU-139908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DLC2 by MAPK8 (Mus musculus)
REACT:R-MMU-109813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1 binds SOS1 (Mus musculus)
RHEA:29896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine(out) => ADP + H(+) + L-glutamine(in) + phosphate
RHEA:29236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H(+) + NADH => a menaquinol + NAD(+)
REACT:R-HSA-9622980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1 binds NPY gene promoter (Homo sapiens)
RHEA:54426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide => L-aspartyl-[protein] + NAD(+)
REACT:R-DRE-1028821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Phospho IRF3 or phospho IRF7 (Danio rerio)
RHEA:40487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:10029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate + H2O + O2 => 2-oxoglutarate + H2O2 + NH4(+)
RHEA:36406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cholesterol ester + H2O <=> a fatty acid + cholesterol + H(+)
GO:0035400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-tyrosine kinase activity
GO:0035400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone tyrosine kinase activity
REACT:R-SPO-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Schizosaccharomyces pombe)
REACT:R-DME-209297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGO binds to the LGS:ARM complex (Drosophila melanogaster)
REACT:R-RNO-9014434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GAPs stimulate RHOG GTPase activity (Rattus norvegicus)
REACT:R-XTR-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Xenopus tropicalis)
REACT:R-RNO-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Rattus norvegicus)
REACT:R-XTR-2161651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGE2 is converted to PGF2a by CBR1 (Xenopus tropicalis)
REACT:R-MMU-8863101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPPL2a/b cleaves TNF(1-76) (Mus musculus)
GO:0008837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LL-2,6-diaminoheptanedioate 2-epimerase activity
GO:0008837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diaminopimelate epimerase activity
RHEA:10557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + L-arginine => H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate
GO:0052818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heteropolysaccharide 3-alpha-mannosyltransferase activity
GO:0052818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:heteroglycan 3-alpha-D-mannosyltransferase activity
GO:0052818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP mannose 3-alpha-mannosyltransferase activity
GO:0052818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose-heteroglycan 3-alpha-mannosyltransferase activity
GO:0052818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heteroglycan 3-alpha-mannosyltransferase activity
REACT:R-CFA-977359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to membrane-associated Factor H:C3b (Canis familiaris)
REACT:R-MMU-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Mus musculus)
REACT:R-HSA-9729232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 nsp1 binds to 40S ribosomal subunit (Homo sapiens)
REACT:R-CEL-419646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:Met (Caenorhabditis elegans)
REACT:R-HSA-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Homo sapiens)
REACT:R-DRE-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Danio rerio)
REACT:R-SCE-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Saccharomyces cerevisiae)
REACT:R-DRE-8847977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRK phosphorylates PTEN (Danio rerio)
REACT:R-CEL-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Caenorhabditis elegans)
REACT:R-DRE-3159259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAA:MUT binds AdoCbl (Danio rerio)
RHEA:14425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
RHEA:14425	skos:altLabel	"phosphatidylinositol-4-phosphate 5-kinase"
RHEA:14425	skos:altLabel	"type I PIP kinase"
RHEA:14425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-phosphatidylinositol-4-phosphate 5-kinase"
RHEA:14425	skos:altLabel	"phosphatidylinositol 4-phosphate kinase"
RHEA:14425	skos:prefLabel	"1-phosphatidylinositol-4-phosphate 5-kinase"
RHEA:14425	skos:altLabel	"diphosphoinositide kinase"
RHEA:14425	skos:altLabel	"PIP kinase"
RHEA:14425	skos:altLabel	"PtdIns(4)P-5-kinase"
RHEA:36581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => dTDP-alpha-D-fucose + NAD(+)
REACT:R-CFA-9006850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor JAK phosphorylation (Canis familiaris)
RHEA:38370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA
REACT:R-DRE-5654404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds SHC1 (Danio rerio)
RHEA:55486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:26041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+) => beta-D-fructose 6-phosphate + GDP-alpha-D-mannose
REACT:R-DDI-1855197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
RHEA:30250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 4 hnu + 2 plastoquinone-9 <=> O2 + 2 plastoquinol-9
REACT:R-RNO-170672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Rattus norvegicus)
RHEA:11038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + quaternary ammonium(in) => ATP + H2O + quaternary ammonium(out)
RHEA:44030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate + H2O => L-altrarate
REACT:R-XTR-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Xenopus tropicalis)
REACT:R-DRE-2465917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerisation of 11c-retinyl to at-retinyl (Danio rerio)
RHEA:59989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1-carbonyl-CoA + NADP(+) => cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH
RHEA:72701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propanoate => acrylate + H(+) + NADH
GO:0050330	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-N-ethyl-L-glutamine amidohydrolase activity
GO:0050330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	theanine hydrolase activity
GO:0050330	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-ethyl-L-glutamine amidohydrolase activity
GO:0050330	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-theanine amidohydrolase activity
RHEA:18931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O => AH2 + O2 + thiophene-2-carbonyl-CoA
REACT:R-DRE-8852010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL2 binds activated T cells surface (Danio rerio)
REACT:R-DME-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Drosophila melanogaster)
GO:0140550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-4,5-bisphosphate sensor activity
GO:0140550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-4,5-bisphosphate sensing activity
RHEA:63370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + spermine(in) => ATP + H2O + spermine(out)
RHEA:34678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + N,N-diacetyllegionaminate <=> CMP-N,N-diacetyllegionaminate + diphosphate
RHEA:10601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 => prostaglandin D2
GO:0047113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + an aldehyde + H2O = a carboxylate + a quinol + H(+)
GO:0047113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde dehydrogenase (acceptor) activity
GO:0047113	skos:altLabel	"aldehyde dehydrogenase (acceptor)"
GO:0047113	skos:prefLabel	"aldehyde dehydrogenase (quinone)"
GO:0047113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity
GO:0047113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde dehydrogenase (quinone) activity
GO:0047113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde dehydrogenase (pyrroloquinoline-quinone)
GO:0047113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldehyde dehydrogenase (quinone)"
REACT:R-GGA-1250189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Gallus gallus)
RHEA:47679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-galactosamine <=> ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate
RHEA:19677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9'-cis-neoxanthin + O2 = (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin
REACT:R-BTA-109530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Bos taurus)
RHEA:50821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => H(+) + NADPH + testosterone
REACT:R-DRE-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Danio rerio)
RHEA:41070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-CEL-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Caenorhabditis elegans)
REACT:R-HSA-209532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR C-terminal fragment enters endosomes (Homo sapiens)
REACT:R-SCE-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Saccharomyces cerevisiae)
RHEA:54474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate => 1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-DDI-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Dictyostelium discoideum)
REACT:R-CEL-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Caenorhabditis elegans)
RHEA:52733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate => adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)
RHEA:31202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyoctanoyl-CoA <=> (2E)-octenoyl-CoA + H2O
RHEA:50755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 naphthalene-1,2,4,8-tetrol + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O
REACT:R-MMU-8944261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIII (Mus musculus)
REACT:R-DRE-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Danio rerio)
RHEA:49345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:29894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-histidine(out) <=> ADP + H(+) + L-histidine(in) + phosphate
REACT:R-CFA-2213017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF3 (Canis familiaris)
REACT:R-DME-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Drosophila melanogaster)
RHEA:23167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose <=> a flavonol 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-BTA-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Bos taurus)
REACT:R-MMU-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Mus musculus)
REACT:R-XTR-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Xenopus tropicalis)
RHEA:50440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H1 = prostaglandin D1
RHEA:14138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine => 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-5228943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcytosis and dissociation of botA:NTNHA:HA (Homo sapiens)
REACT:R-SSC-433089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT can transport taurolithocholate-3-sulphate (Sus scrofa)
RHEA:65267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypentacecilide A + A <=> AH2 + chrodrimanin C
REACT:R-SCE-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)
REACT:R-RNO-428127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Rattus norvegicus)
RHEA:24550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + L-lysine => an N(6)-acyl-L-lysine + H2O
RHEA:55840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP
REACT:R-SSC-2076508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS2ST1 sulfates IdoA at C2 in heparan sulfate (Sus scrofa)
RHEA:29639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaose + H2O = alpha-D-glucose + D-maltopentaose
REACT:R-XTR-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)
REACT:R-PFA-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Plasmodium falciparum)
REACT:R-HSA-8983983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Homo sapiens)
REACT:R-SSC-389758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)
REACT:R-DME-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Drosophila melanogaster)
RHEA:23909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine => 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine
REACT:R-XTR-6786190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMBL hydrolyses OM to OLMS (Xenopus tropicalis)
REACT:R-HSA-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Homo sapiens)
RHEA:70017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + teasterone
REACT:R-HSA-8854408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOBR dimer binds VLDLs (Homo sapiens)
REACT:R-XTR-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Xenopus tropicalis)
REACT:R-SSC-202375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ITK to SLP-76 (Sus scrofa)
GO:0031858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PACAP receptor binding
GO:0031858	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pituitary adenylate cyclase-activating peptide receptor ligand
GO:0031858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pituitary adenylate cyclase-activating polypeptide receptor binding
GO:0031858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pituitary adenylate cyclase activating peptide receptor binding
GO:0019166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent trans-2-enoyl-CoA reductase activity
GO:0019166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DECR2 reduces LCtE-CoA to t3enoyl-CoA (Homo sapiens)
GO:0019166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:NADP+ trans-2-oxidoreductase activity
GO:0019166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2-enoyl-CoA reductase (NADPH) activity
GO:0019166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, trans-enoyl coenzyme A
REACT:R-BTA-428127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Bos taurus)
REACT:R-MMU-9734475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds fibrates (Mus musculus)
REACT:R-SSC-158766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Sus scrofa)
REACT:R-HSA-1655833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TM7SF2 (Homo sapiens)
REACT:R-CEL-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Caenorhabditis elegans)
RHEA:18470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + L-glutamine => an N(2)-acyl-L-glutamine + CoA + H(+)
EC:1.22.1.-	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
EC:1.22.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
REACT:R-HSA-5220990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine (Homo sapiens)
RHEA:64115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-phenylalanine + H2O <=> a fatty acid + L-phenylalanine
REACT:R-BTA-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
RHEA:42978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + indole => L-tryptophan
REACT:R-SSC-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Sus scrofa)
REACT:R-BTA-429955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR4-NOT complex deadenylates mRNA (Bos taurus)
RHEA:13061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + S-sulfanylglutathione = glutathione S,S-dioxide + H(+)
GO:0036217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP diphosphatase activity
GO:0036217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + H2O = dGMP + diphosphate + H(+)
GO:0036217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP pyrophosphatase activity
GO:0036217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine 5'-triphosphate diphosphohydrolase
RHEA:54391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
RHEA:31597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylaminoacrylate + carbamate + H(+) => (Z)-2-methylureidoacrylate + H2O
REACT:R-MMU-5684862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Mus musculus)
REACT:R-SCE-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Saccharomyces cerevisiae)
REACT:R-DRE-264615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Danio rerio)
RHEA:51407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine + O2 <=> 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)
REACT:R-CEL-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Caenorhabditis elegans)
REACT:R-RNO-389632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)
RHEA:69279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> but-3-enenitrile + sulfate + sulfur
RHEA:34553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate c monoamide + H2O + L-glutamine
REACT:R-CFA-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Canis familiaris)
REACT:R-GGA-191763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP:Snurportin complex formation (Gallus gallus)
REACT:R-GGA-3371359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Gallus gallus)
RHEA:50256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:48509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NADP(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH
REACT:R-SSC-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Sus scrofa)
REACT:R-MMU-5654673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Mus musculus)
RHEA:42962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 oxidized [nitric oxide reductase rubredoxin domain] => H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain]
RHEA:11278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 benzosemiquinone + 2 H2O => 4 hydroquinone + O2
REACT:R-BTA-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Bos taurus)
RHEA:60402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O
REACT:R-BTA-2046084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Bos taurus)
REACT:R-GGA-9750226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 binds IKBKB and CHUK (Gallus gallus)
RHEA:60241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate
RHEA:25812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine
RHEA:16534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP
RHEA:23318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil => 2'-deoxyuridine + 2-oxoglutarate + O2
REACT:R-HSA-171106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex => LDLR + LDL (Homo sapiens)
RHEA:19054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O => H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin
REACT:R-CFA-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Canis familiaris)
REACT:R-BTA-1655842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P hydrolyzes SREBP1A,1C,2 (Bos taurus)
RHEA:14620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glutathione + NADP(+) <=> CoA-glutathione + H(+) + NADPH
REACT:R-XTR-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Xenopus tropicalis)
REACT:R-GGA-8865482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KMT2A (MLL) binds RUNX1 (Gallus gallus)
REACT:R-RNO-5638333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)
REACT:R-SCE-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Saccharomyces cerevisiae)
RHEA:25246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-lactoylglutathione + H2O => (R)-lactate + glutathione + H(+)
RHEA:13831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-alpha-D-rhamnose + NADP(+)
REACT:R-RNO-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Rattus norvegicus)
RHEA:38162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-hydroxyarginine <=> (2S,3R)-capreomycidine + H2O
REACT:R-CEL-400097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-beta:G-gamma inhibits Adenylate cyclase (Caenorhabditis elegans)
GO:0015651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quaternary ammonium compound transporter activity
GO:0015651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quaternary amine transmembrane transporter activity
GO:0015651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quaternary ammonium group transmembrane transporter activity
REACT:R-CFA-2984220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1:CCNB phosphorylates NEK9 (Canis familiaris)
RHEA:44872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-XTR-2294580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 hyperphosphorylates Condensin II complex (Xenopus tropicalis)
RHEA:48727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin B + H(+) + H2O <=> 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide
RHEA:15246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacylglycerol + H2O => a fatty acid + glycerol + H(+)
RHEA:35515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4'''-malonyltransferase"
RHEA:35515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'''-demalonylsalvianin + malonyl-CoA = CoA + salvianin
RHEA:35515	skos:prefLabel	"pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4'''-malonyltransferase"
REACT:R-RNO-158942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)
RHEA:65500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase"
RHEA:65500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine
RHEA:65500	skos:prefLabel	"3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase"
RHEA:50446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin G3 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2
REACT:R-MMU-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Mus musculus)
RHEA:37843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:31345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O
RHEA:25585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnose => beta-L-rhamnose
REACT:R-RNO-6784204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind OSMR (Rattus norvegicus)
REACT:R-BTA-8862137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B2 oxidises estradiol (E2) to estrone (E1) (Bos taurus)
REACT:R-GGA-8939203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Gallus gallus)
REACT:R-RNO-9027302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Rattus norvegicus)
REACT:R-CFA-8875451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates CBL (Canis familiaris)
REACT:R-RNO-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Rattus norvegicus)
RHEA:46267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:34668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + S-adenosyl-L-methionine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-1471338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 1, 4A and 103 bind CCR6 (Canis familiaris)
REACT:R-DRE-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Danio rerio)
RHEA:55558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an oxoeicosatetraenoate + H2O => a hydroperoxyeicosatetraenoate
REACT:R-DDI-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Dictyostelium discoideum)
RHEA:27541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde
RHEA:40546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9620004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSKs autophosphorylate (Homo sapiens)
RHEA:14199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-asparagine + phosphate => ATP + L-aspartate + NH4(+)
RHEA:46825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:40367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)
REACT:R-RNO-4332359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active calmodulin binds CAMK2 (Rattus norvegicus)
RHEA:44144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-methionine = CoA + H(+) + N(alpha)-acetyl-L-methionine
REACT:R-SCE-2066779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Saccharomyces cerevisiae)
REACT:R-DDI-5668735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX3 complex (Dictyostelium discoideum)
RHEA:39411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA = (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O
REACT:R-SSC-2022383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)
REACT:R-MMU-3257122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Mus musculus)
RHEA:54300	skos:altLabel	"GalNAc4S-6ST"
RHEA:54300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate = n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)
RHEA:54300	skos:prefLabel	"N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase"
RHEA:54300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase"
RHEA:54300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate = n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)
REACT:R-CEL-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Caenorhabditis elegans)
REACT:R-HSA-400459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 (Homo sapiens)
REACT:R-SCE-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Saccharomyces cerevisiae)
RHEA:17812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-protoporphyrin IX + S-adenosyl-L-methionine <=> Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine
REACT:R-DRE-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Danio rerio)
RHEA:55635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)
REACT:R-MMU-6805785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates PHF20 (Mus musculus)
REACT:R-GGA-9661432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds ALB (Gallus gallus)
RHEA:45063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl) ethanolamine <=> (9Z)-octadecenoate + ethanolamine
REACT:R-MMU-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Mus musculus)
RHEA:36505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA => (9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA
REACT:R-HSA-192157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
REACT:R-MMU-6814549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
RHEA:63177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ibuprofenoyl-CoA => (2R)-ibuprofenoyl-CoA
GO:0080102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylthiopropyl glucosinolate S-oxygenase activity
RHEA:62007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)
RHEA:63290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-RNO-3318413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Rattus norvegicus)
REACT:R-SSC-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Sus scrofa)
REACT:R-DRE-8853965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Danio rerio)
GO:0047957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-methoxyisoflavone 2'-hydroxylase activity
GO:0047957	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)
GO:0047957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formononetin + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0047957	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isoflavone 2'-monooxygenase activity
REACT:R-HSA-2328033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds latent TGF-beta (Homo sapiens)
RHEA:40914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
RHEA:60447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteinylglycine + H2O <=> an S-substituted L-cysteine + glycine
RHEA:19411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH => cholate + NAD(+)
REACT:R-CEL-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Caenorhabditis elegans)
RHEA:59531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]
REACT:R-RNO-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Rattus norvegicus)
REACT:R-SSC-5218839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Sus scrofa)
RHEA:19419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n+1) + a dolichyl phosphate => [phosphate](n) + a dolichyl diphosphate
RHEA:21141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + inosine => ADP + H(+) + IMP
REACT:R-HSA-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)
RHEA:39706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (13Z)-eicosenoyl-CoA + NADP(+)
REACT:R-RNO-2179413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC-alpha  activate MMP3 (Rattus norvegicus)
REACT:R-MMU-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Mus musculus)
RHEA:69567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine <=> 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O
EC:2.7.13.3	skos:altLabel	"protein kinase (histidine)"
EC:2.7.13.3	skos:altLabel	"protein kinase"
EC:2.7.13.3	skos:altLabel	"histidine protein kinase"
EC:2.7.13.3	skos:altLabel	"HK1"
EC:2.7.13.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histidine kinase"
EC:2.7.13.3	skos:prefLabel	"histidine kinase"
EC:2.7.13.3	skos:altLabel	"protein histidine kinase"
REACT:R-CFA-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Canis familiaris)
RHEA:54445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3S,4S)-leucoanthocyanidin + NADP(+) => a (2R,3R)-dihydroflavonol + H(+) + NADPH
RHEA:54859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + octan-3-one <=> ethyl hexanoate + H2O + NADP(+)
REACT:R-HSA-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)
RHEA:32375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene-1,2-diol + NAD(+) = 1-hydroxylimonen-2-one + H(+) + NADH
RHEA:71066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-histidine(out) <=> L-arginine(out) + L-histidine(in)
RHEA:70336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-L-lyxonolactone + H2O => 2-carboxy-L-lyxonate + H(+)
REACT:R-HSA-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Homo sapiens)
RHEA:45744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydropteroate + NAD(+) = 7,8-dihydropteroate + H(+) + NADH
REACT:R-XTR-2076392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcA to heparan (Xenopus tropicalis)
REACT:R-SCE-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Saccharomyces cerevisiae)
REACT:R-HSA-5696365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Homo sapiens)
RHEA:69378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxododecanoate + H2O2 => 2-hydroxydodecanoate + O2
RHEA:38755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:60820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH = adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide
RHEA:25450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-guaia-6,9-diene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:48350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pseudouridine in RNA => a uridine in RNA
GO:0015216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine nucleotide transmembrane transporter activity
RHEA:70847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-cysteine(out) + Na(+)(out) = L-arginine(out) + L-cysteine(in) + Na(+)(in)
RHEA:53958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoyl-[BtrI ACP] + CO2 => gamma-L-glutamyl-[BtrI ACP] + H(+)
GO:0051732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-hydroxyl RNA kinase activity
GO:0051732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA 5'-hydroxyl kinase activity
GO:0051732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-hydroxyl polyribonucleotide kinase activity
GO:0051732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyribonucleotide kinase activity
GO:0051732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA kinase activity
REACT:R-SPO-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Schizosaccharomyces pombe)
GO:0044750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity nickel cation transmembrane transporter activity
RHEA:14383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanoate + 2 H(+) + NADH => 4-guanidinobutanal + H2O + NAD(+)
RHEA:41521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-4086205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN (osteopontin) degradation by MMP3, MMP7 (Bos taurus)
REACT:R-RNO-8857925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Rattus norvegicus)
REACT:R-RNO-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Rattus norvegicus)
REACT:R-HSA-183126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to surface-associated C3b (Homo sapiens)
REACT:R-DRE-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Danio rerio)
RHEA:39885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH => dTDP-6-deoxy-alpha-D-allose + NADP(+)
RHEA:25546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ent-pimara-9(11),15-diene => ent-copalyl diphosphate
RHEA:48711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
REACT:R-CFA-2730870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
REACT:R-SSC-451561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO binds polyubiquitinated IRAK1 (Sus scrofa)
REACT:R-SCE-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Saccharomyces cerevisiae)
RHEA:52674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate
RHEA:51743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)
RHEA:67939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxy carboxylate + O2 <=> a 2-oxocarboxylate + H2O2
RHEA:38974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O2
REACT:R-HSA-141156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL-mediated dimerization of procaspase-8 (Homo sapiens)
REACT:R-SSC-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Sus scrofa)
REACT:R-SSC-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Sus scrofa)
REACT:R-HSA-202214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
GO:0102161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copal-8-ol diphosphate synthase activity
REACT:R-DME-9614273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGRG heterodimer translocates to plasma membrane (Drosophila melanogaster)
GO:0050388	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uronate:NAD+ 1-oxidoreductase activity
GO:0050388	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uronic acid dehydrogenase activity
GO:0050388	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uronate: NAD-oxidoreductase activity
GO:0050388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uronate dehydrogenase activity
REACT:R-XTR-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Xenopus tropicalis)
RHEA:41574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => lipoxin A4 + NAD(+)
REACT:R-DDI-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Dictyostelium discoideum)
RHEA:70512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:71935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2 Na(+)(in)
RHEA:18244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine <=> (2R,5S)-2,5-diaminohexanoate
EC:1.5.1.43	skos:altLabel	"carboxynorspermidine dehydrogenase"
EC:1.5.1.43	skos:prefLabel	"carboxynorspermidine synthase"
EC:1.5.1.43	skos:altLabel	"carboxyspermidine dehydrogenase"
EC:1.5.1.43	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxynorspermidine synthase"
REACT:R-SSC-8869606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NAR to yield NAMN (Sus scrofa)
REACT:R-DRE-2468287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Danio rerio)
REACT:R-SSC-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Sus scrofa)
REACT:R-CEL-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Caenorhabditis elegans)
REACT:R-HSA-6791285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the BID gene promoter (Homo sapiens)
REACT:R-SSC-209859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decarboxylation of 5-hydroxytryptophan forms serotonin (Sus scrofa)
RHEA:26179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine <=> 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)
REACT:R-HSA-380927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
REACT:R-HSA-9664646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K (Homo sapiens)
RHEA:71512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phylloquinone(out) => phylloquinone(in)
REACT:R-MMU-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Mus musculus)
RHEA:19796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]
REACT:R-MMU-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Mus musculus)
REACT:R-MMU-8940561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP7 cleaves OPTC (Mus musculus)
RHEA:50876	skos:prefLabel	"hydroperoxy fatty acid reductase"
RHEA:50876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH = a hydroxy polyunsaturated fatty acid + H2O + NADP(+)
RHEA:50876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroperoxy fatty acid reductase"
RHEA:39501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA
REACT:R-DDI-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Dictyostelium discoideum)
RHEA:14023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxyecdysone + A + H2O => AH2 + ecdysone + O2
RHEA:69506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + N-acetyl-D-glucosamino-1,5-lactone => N-acetyl-D-glucosamine + O2
RHEA:42666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arabinono-1,4-lactone + NADPH => alpha-L-arabinopyanose + NADP(+)
REACT:R-DME-2031355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)
REACT:R-PFA-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)
RHEA:55165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 => H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)
GO:0000334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)
GO:0000334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyanthranilic acid dioxygenase activity
GO:0000334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyanthranilate oxygenase activity
GO:0000334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyanthranilic acid oxygenase activity
GO:0000334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0000334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyanthranilic oxygenase activity
GO:0000334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3HAO
REACT:R-SSC-450595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR:mRNA complex translocates from the nucleus to the cytosol (Sus scrofa)
REACT:R-MMU-8983872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Mus musculus)
RHEA:24807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(1-hydroxyethyl)thiamine diphosphate + pyruvate => (2S)-2-acetolactate + thiamine diphosphate
REACT:R-MMU-6809707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTMR2 (Mus musculus)
GO:0102093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylate:acyl-coA CoA transferase activity
RHEA:31422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> (-)-beta-curcumene + diphosphate
REACT:R-HSA-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Homo sapiens)
REACT:R-BTA-6799977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 hydrolyzes bacterial peptidoglycan (Bos taurus)
REACT:R-SSC-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Sus scrofa)
RHEA:43386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(omega)-phospho-L-arginyl-[protein] => ATP + L-arginyl-[protein]
REACT:R-BTA-5684806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates CLEC1B dimer:PDPN (Bos taurus)
GO:0051432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH1 domain binding
RHEA:62341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-malbrancheamide C + FADH2
REACT:R-SCE-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Saccharomyces cerevisiae)
GO:0001640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0001640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylate cyclase inhibiting metabotropic glutamate receptor activity
GO:0001640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl cyclase inhibiting metabotropic glutamate receptor activity
REACT:R-HSA-1235070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Erythropoietin (EPO) (Homo sapiens)
REACT:R-CEL-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Caenorhabditis elegans)
RHEA:47993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + NAD(+) + NADPH => H(+)(out) + NADH + NADP(+)
REACT:R-SSC-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Sus scrofa)
RHEA:14245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O = AMP + diphosphate + H(+)
RHEA:63054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O
REACT:R-DRE-5654224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds PLCG1 (Danio rerio)
RHEA:54527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + H(+) + methylglyoxal <=> 3-hydroxyhexane-2,5-dione + CO2
REACT:R-DDI-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Dictyostelium discoideum)
REACT:R-HSA-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Homo sapiens)
REACT:R-HSA-1592252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TFB2M (Homo sapiens)
REACT:R-BTA-9626816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds p-S345-NCF1 (Bos taurus)
RHEA:35057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-2,5-dichloromuconate + H(+) => 3,6-dichlorocatechol + O2
REACT:R-CFA-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Canis familiaris)
REACT:R-CFA-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Canis familiaris)
REACT:R-BTA-1297444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of cAMP to HCN channels (Bos taurus)
REACT:R-DDI-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Dictyostelium discoideum)
REACT:R-HSA-5696670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD1L is recruited to GG-NER site (Homo sapiens)
RHEA:16478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prostaglandin E1 => 15-oxoprostaglandin E1 + H(+) + NADH
REACT:R-BTA-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Bos taurus)
REACT:R-SCE-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Saccharomyces cerevisiae)
RHEA:12212	skos:prefLabel	"fluoren-9-ol dehydrogenase"
RHEA:12212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-fluoren-9-ol + NADP(+) = 9H-fluoren-9-one + H(+) + NADPH
RHEA:12212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-fluoren-9-ol + NAD(+) = 9H-fluoren-9-one + H(+) + NADH
RHEA:12212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fluoren-9-ol dehydrogenase"
RHEA:19346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate
RHEA:41892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O
RHEA:18153	skos:prefLabel	"guanosine-triphosphate guanylyltransferase"
RHEA:18153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 GTP + H(+) = diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate
RHEA:18153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanosine-triphosphate guanylyltransferase"
RHEA:28431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allose 6-phosphate => D-allulose 6-phosphate
REACT:R-DRE-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Danio rerio)
RHEA:68014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + xanthine => H2O + hypoxanthine + O2
REACT:R-PFA-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Plasmodium falciparum)
GO:0033853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-prephenate aminotransferase activity
GO:0033853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arogenate:oxaloacetate aminotransferase activity
GO:0033853	skos:altLabel	"prephenate aspartate aminotransferase"
GO:0033853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prephenate aspartate aminotransferase activity
GO:0033853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate:prephenate aminotransferase activity
GO:0033853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate--prephenate aminotransferase"
GO:0033853	skos:prefLabel	"aspartate--prephenate aminotransferase"
GO:0033853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAT
GO:0033853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arogenate + oxaloacetate = L-aspartate + prephenate
GO:0033853	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	prephenate transaminase activity
GO:0033853	skos:altLabel	"PAT"
GO:0033853	skos:altLabel	"L-aspartate:prephenate aminotransferase"
GO:0033853	skos:altLabel	"prephenate transaminase"
GO:0004644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GAR TFase activity
GO:0004644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-phosphoribosylglycinamide transformylase activity
GO:0004644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity
GO:0004644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GAR formyltransferase activity
GO:0004644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GAR transformylase activity
GO:0004644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GART activity
GO:0004644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-N-ribosylacetamide 5'-phosphate transformylase activity
GO:0004644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity
GO:0004644	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycinamide ribonucleotide transformylase activity
GO:0004644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosylglycinamide formyltransferase activity
REACT:R-DDI-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Dictyostelium discoideum)
REACT:R-RNO-444848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 1 binds relaxin 3 (Rattus norvegicus)
REACT:R-GGA-1638803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)
REACT:R-RNO-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)
REACT:R-SSC-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Sus scrofa)
REACT:R-SSC-1250357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds P-ERBB4 isoform dimers (Sus scrofa)
GO:0050664	skos:prefLabel	"With oxygen as acceptor"
GO:0050664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
GO:0050664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
GO:0050664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
REACT:R-DRE-975103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Danio rerio)
REACT:R-DRE-9026967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 inhibitors binds VKORC1 dimer (Danio rerio)
RHEA:26418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal
REACT:R-XTR-2464809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates the transport of atROL from ROS to RPE (Xenopus tropicalis)
REACT:R-XTR-3238999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Xenopus tropicalis)
REACT:R-GGA-9021660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds membrane-associated estrogen receptors (Gallus gallus)
GO:0106244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0106244	skos:altLabel	"CYP71DD6"
GO:0106244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"eupatolide synthase"
GO:0106244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eupatolide synthase activity
GO:0106244	skos:prefLabel	"eupatolide synthase"
REACT:R-DME-2396029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-3 binds integrins (Drosophila melanogaster)
RHEA:60848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]
REACT:R-HSA-8854604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D16 accelerates GTP hydrolysis by RAB4A (Homo sapiens)
REACT:R-BTA-372693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
RHEA:66857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 3 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
RHEA:59128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP = 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate
RHEA:59128	skos:prefLabel	"2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase"
RHEA:59128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase"
REACT:R-DDI-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Dictyostelium discoideum)
REACT:R-DRE-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Danio rerio)
RHEA:18107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O
RHEA:53993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-SSC-2066788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Sus scrofa)
REACT:R-BTA-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)
REACT:R-SSC-2152276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of transmembrane collagens (Sus scrofa)
REACT:R-MMU-111253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Mus musculus)
REACT:R-RNO-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Rattus norvegicus)
RHEA:32164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine => AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine
RHEA:52410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dihydroxyacetone phosphate + NADH => 4-phospho-D-erythronate + NAD(+)
REACT:R-MMU-8956099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Mus musculus)
REACT:R-DDI-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Dictyostelium discoideum)
REACT:R-MMU-389632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Mus musculus)
RHEA:69554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-serinol phosphate + 2-oxoglutarate => dihydroxyacetone phosphate + L-glutamate
EC:3.4.24.86	skos:prefLabel	"ADAM 17 endopeptidase"
EC:3.4.24.86	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADAM 17 endopeptidase"
EC:3.4.24.86	skos:altLabel	"tumor necrosis factor alpha-converting enzyme"
EC:3.4.24.86	skos:altLabel	"TACE"
REACT:R-CFA-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Canis familiaris)
REACT:R-CFA-4088141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)
RHEA:21596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH
RHEA:40528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinol + 4 H(+)(in) + O2(in) => 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)
REACT:R-RNO-8944266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XI (Rattus norvegicus)
REACT:R-MMU-373074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR9  binds CCL25 ligand (Mus musculus)
REACT:R-DDI-2090085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan chain(1) (Dictyostelium discoideum)
RHEA:34964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) => Na(+)(out)
REACT:R-DME-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Drosophila melanogaster)
RHEA:69501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + NAD(+) => ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide
GO:0034805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity
RHEA:24412	skos:prefLabel	"4-(hydroxymethyl)benzenesulfonate dehydrogenase"
RHEA:24412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-(hydroxymethyl)benzenesulfonate dehydrogenase"
RHEA:24412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH
RHEA:25583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-fucose <=> beta-L-fucose
GO:0051435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH4 domain binding
REACT:R-DRE-8963851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 dissociates from GC (Danio rerio)
GO:0016279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-lysine N-methyltransferase activity
GO:0016279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein lysine methylase activity
GO:0016279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein (lysine) methyltransferase activity
RHEA:33408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + H(+) => diphosphate + glycyl-5'-AMP
REACT:R-BTA-8933452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE dimer binds phosphorylated DENND1 proteins (Bos taurus)
REACT:R-DME-442273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV1 is a GEF for Rho/Rac family GTPases (Drosophila melanogaster)
RHEA:16761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorohydroquinone + O2 = 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)
REACT:R-RNO-420593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR:PVRL3 trans heterodimer interaction (Rattus norvegicus)
REACT:R-DRE-140842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n fibrin monomers -> fibrin multimer (Danio rerio)
RHEA:59196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP = AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]
RHEA:47656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-methionine sulfone = CoA + H(+) + N-acetyl-L-methionine sulfone
RHEA:47295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1676020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Rattus norvegicus)
REACT:R-MMU-4084999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU1 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)
REACT:R-DRE-196402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Danio rerio)
REACT:R-HSA-167076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)
REACT:R-SSC-159005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)
GO:0018365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-serine epimerase activity
GO:0018365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-serine racemase activity
RHEA:37111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine
RHEA:46420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-190782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of connexon-containing transport vesicles from the Golgi (Bos taurus)
REACT:R-SPO-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Schizosaccharomyces pombe)
GO:0034876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isonicotinic acid hydrazide hydrolase activity
REACT:R-GGA-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
GO:0051035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA transmembrane transporter activity
RHEA:20057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-carbamoylsarcosine amidase"
RHEA:20057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-carbamoylsarcosine = CO2 + NH4(+) + sarcosine
RHEA:20057	skos:altLabel	"N-carbamoylsarcosine amidohydrolase"
RHEA:20057	skos:prefLabel	"N-carbamoylsarcosine amidase"
RHEA:20057	skos:altLabel	"CSHase"
GO:0000405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bubble DNA binding
RHEA:28149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5654399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS2 (Canis familiaris)
RHEA:30413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl benzoate + CoA => benzoyl-CoA + benzyl alcohol
RHEA:25627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + imidazole-4-acetaldehyde + NH4(+) => H2O + histamine + O2
REACT:R-GGA-75080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC A complex (Gallus gallus)
RHEA:21432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malate dehydrogenase"
RHEA:21432	skos:altLabel	"malic dehydrogenase"
RHEA:21432	skos:prefLabel	"malate dehydrogenase"
RHEA:21432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate
REACT:R-RNO-5624953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL13B binds INPP5E (Rattus norvegicus)
RHEA:13485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine-conjugate transaminase"
RHEA:13485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate
RHEA:13485	skos:prefLabel	"cysteine-conjugate transaminase"
REACT:R-MMU-508451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B is phosphorylated (Mus musculus)
RHEA:59125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + ATP + citrate => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate
GO:0102145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-(E)-nerolidol synthase activity
GO:0102145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate
GO:0102145	skos:prefLabel	"(3R,6E)-nerolidol synthase"
GO:0102145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(3R,6E)-nerolidol synthase"
REACT:R-DME-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Drosophila melanogaster)
RHEA:71932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(out) + 3 Na(+)(out) => fumarate(in) + 3 Na(+)(in)
REACT:R-BTA-203625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)
REACT:R-PFA-1483089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is converted to PS by PTDSS2 (Plasmodium falciparum)
RHEA:57665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1306957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
REACT:R-RNO-2060328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS1 (Rattus norvegicus)
REACT:R-MMU-6809393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filaments bind cell-cell adhesion complexes (Mus musculus)
RHEA:54903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-[ACP] + H(+) + NADH <=> hexadecanoyl-[ACP] + NAD(+)
REACT:R-CEL-1855153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)
RHEA:72620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate
REACT:R-SSC-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Sus scrofa)
REACT:R-CEL-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Caenorhabditis elegans)
REACT:R-DME-8848993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated KHDRBS1 translocates to the cytosol (Drosophila melanogaster)
RHEA:29072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + formate + H(+) => a ubiquinol + CO2
REACT:R-CEL-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)
RHEA:66640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = diphosphate + koraiol
REACT:R-BTA-2161660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGE2 by PTGES (Bos taurus)
RHEA:36802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + H2O <=> a ribonucleoside 5'-phosphate + H(+) + phosphate
RHEA:63265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine
REACT:R-MMU-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Mus musculus)
RHEA:44941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)
RHEA:65098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-hexadecanoyl-2-acylglycerol + CoA => a 2-acylglycerol + hexadecanoyl-CoA
REACT:R-DRE-390304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoASH (Danio rerio)
RHEA:26403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone => all-trans-10'-apo-beta-carotenal + O2
RHEA:13114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetamidofluorene + H2O + NADP(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADPH
GO:0019239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Homo sapiens)
GO:0019239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deaminase activity
REACT:R-RNO-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Rattus norvegicus)
RHEA:48797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Xenopus tropicalis)
RHEA:43411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP
REACT:R-SSC-71260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Sus scrofa)
REACT:R-SSC-5638012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D dissociates from ARL13B:INPP5E (Sus scrofa)
RHEA:62729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide B + bromide + FAD + 2 H(+) => (+)-malbrancheamide D + FADH2
RHEA:15170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-succinyl-L-glutamate => L-glutamate + succinate
REACT:R-XTR-3159253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAB adenosylates cob(I)alamin (Xenopus tropicalis)
GO:0047775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:citramalate CoA-transferase activity
GO:0047775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citramalate CoA-transferase activity
REACT:R-DRE-9629470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Danio rerio)
REACT:R-HSA-8874197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3 translocates from the cytosol to the nucleus (Homo sapiens)
REACT:R-DDI-266051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)
RHEA:19502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanoate + H2O => 4-aminobutanoate + urea
RHEA:61446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11a-hydroxytetracycline + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2
RHEA:26222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-174757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Homo sapiens)
REACT:R-SSC-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Sus scrofa)
RHEA:51963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylpropanal oxime <=> 2-methylpropanenitrile + H2O
REACT:R-SPO-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Schizosaccharomyces pombe)
REACT:R-HSA-6804253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates JMY (Homo sapiens)
RHEA:13476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan + NAD(+) <=> H(+) + indole-3-pyruvate + NADH + NH4(+)
RHEA:15566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-amino acid + H2O => a carboxylate + an L-alpha-amino acid
REACT:R-DDI-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Dictyostelium discoideum)
GO:0140630	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phytoene synthase activity
GO:0140630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-phytoene synthase activity
RHEA:13746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascopyrone M => microthecin
REACT:R-CEL-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Caenorhabditis elegans)
REACT:R-GGA-352961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + glyceraldehyde 3-phosphate <=> fructose 1,6-bisphosphate (Gallus gallus)
RHEA:47770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine
REACT:R-DDI-70920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Dictyostelium discoideum)
RHEA:11495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-phospho-L-threonine <=> (R)-1-aminopropan-2-yl phosphate + CO2
RHEA:46393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5684801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y7-CLEC1B dimer:PDPN binds SYK (Canis familiaris)
RHEA:18628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + NADP(+) <=> D-galactono-1,5-lactone + H(+) + NADPH
REACT:R-HSA-6810234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
REACT:R-SCE-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Saccharomyces cerevisiae)
REACT:R-SPO-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-RNO-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Rattus norvegicus)
RHEA:41902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + tetradecanoyl-[ACP]
REACT:R-HSA-9665232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)
RHEA:57132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate + O2 + tyramine = (R)-octopamine + H2O + L-dehydroascorbate
REACT:R-DRE-9021170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen stimulates dimerization of plasma membrane estrogen receptors (Danio rerio)
GO:0103058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 3-glucoside 7-O-rhamnosyltransferase activity
REACT:R-DRE-4085033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Danio rerio)
REACT:R-GGA-198266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)
RHEA:38693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in)
REACT:R-DDI-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Dictyostelium discoideum)
RHEA:72339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) = catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
RHEA:59800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-DME-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)
REACT:R-BTA-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Bos taurus)
RHEA:30047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetaldehyde + H2O + NAD(+) = chloroacetate + 2 H(+) + NADH
RHEA:56626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+) => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O
REACT:R-HSA-9617735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN disrupts FOXO4 complex with EP300 (Homo sapiens)
GO:0045352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1 type I receptor antagonist activity
GO:0045352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-1ra type I
REACT:R-MMU-2731074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Mus musculus)
REACT:R-DRE-3900194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates DDX5 with SUMO2 (Danio rerio)
REACT:R-SSC-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Sus scrofa)
GO:1990698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoleoyltransferase activity
GO:0106378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-dATP diphosphatase"
GO:0106378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-dATP hydrolase activity
GO:0106378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)
GO:0106378	skos:altLabel	"(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase"
GO:0106378	skos:prefLabel	"2-hydroxy-dATP diphosphatase"
GO:0106378	skos:altLabel	"oxidized purine nucleoside triphosphatase"
REACT:R-SCE-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Saccharomyces cerevisiae)
GO:0031822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 1B receptor binding
GO:0031822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1B serotonin receptor binding
GO:0031822	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1B serotonin receptor ligand
REACT:R-HSA-4088309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXM1 binds CCNB2 promoter (Homo sapiens)
REACT:R-HSA-1472121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of p-KIT on Y900 by Src kinases (Homo sapiens)
RHEA:68098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+) => a ribonucleotidyl-ribonucleotide-RNA + H2O
RHEA:22356	skos:altLabel	"phosphopyruvate carboxylase"
RHEA:22356	skos:altLabel	"phosphoenolpyruvate carboxylase"
RHEA:22356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate
RHEA:22356	skos:prefLabel	"phosphoenolpyruvate carboxykinase (diphosphate)"
RHEA:22356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoenolpyruvate carboxykinase (diphosphate)"
RHEA:22356	skos:altLabel	"PEP carboxyphosphotransferase"
RHEA:22356	skos:altLabel	"phosphoenolpyruvate carboxykinase (pyrophosphate)"
REACT:R-CEL-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Caenorhabditis elegans)
REACT:R-MMU-5229111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 transports APP from trans-Golgi network to endosome lumen (Mus musculus)
RHEA:51751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A <=> 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate
RHEA:47124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hexacosanoate = H2O + N-hexacosanoylglycine
REACT:R-HSA-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Homo sapiens)
REACT:R-MMU-4332358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CaM and CAMK2 autophosphorylation (Mus musculus)
REACT:R-HSA-5655269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 mutants bind FRS2 (Homo sapiens)
REACT:R-MMU-6781897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP11 deubiquitinates NFKBIA (Mus musculus)
REACT:R-SSC-9687625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds MLKL (Sus scrofa)
REACT:R-XTR-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Xenopus tropicalis)
RHEA:68227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + O2 + prekainate <=> CO2 + H2O + kainate lactone + succinate
REACT:R-RNO-9638076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)
REACT:R-XTR-981814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC2 transfers sialic acid to Core 1 mucins (Xenopus tropicalis)
REACT:R-HSA-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Homo sapiens)
REACT:R-MMU-5696146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC2 deaminates TYR (Mus musculus)
GO:0015079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K(+)(in) = K(+)(out)
GO:0015079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium transporter activity
GO:0015079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium ion transmembrane transporter activity
GO:0015079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	potassium uptake transmembrane transporter activity
GO:0015079	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	potassium uptake permease activity
REACT:R-HSA-389632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Homo sapiens)
RHEA:48120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 + H2O = ganglioside GM3 + N-acetylneuraminate
RHEA:33158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycerol + phosphate
EC:3.1.21.-	skos:prefLabel	"Endodeoxyribonucleases producing 5'-phosphomonoesters"
EC:3.1.21.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Endodeoxyribonucleases producing 5'-phosphomonoesters"
RHEA:55257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Canis familiaris)
REACT:R-BTA-1168638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated IKK phosphorylates I-kappaB (Bos taurus)
REACT:R-DME-201443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II receptor phosphorylates type I receptor (Drosophila melanogaster)
RHEA:35976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 => A + CO2 + H2O + succinate + verruculogen
RHEA:17309	skos:altLabel	"paraoxonase"
RHEA:17309	skos:prefLabel	"arylesterase"
RHEA:17309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arylesterase"
RHEA:17309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenyl acetate + H2O = a phenol + acetate + H(+)
RHEA:17309	skos:altLabel	"A-esterase"
RHEA:40025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + syn-copalol => 9alpha-copalyl diphosphate + H2O
REACT:R-DRE-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Danio rerio)
REACT:R-DRE-72127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal B Complex (Danio rerio)
RHEA:30683	skos:prefLabel	"UDP-N-acetylglucosamine 2-epimerase (hydrolyzing)"
RHEA:30683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine 2-epimerase (hydrolyzing)"
RHEA:30683	skos:altLabel	"UDP-N-acetylglucosamine 2-epimerase"
RHEA:30683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D-mannosamine + UDP
REACT:R-RNO-443779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Linkage of L1 with treadmilling F-actin (Rattus norvegicus)
REACT:R-XTR-2309787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS2 (Xenopus tropicalis)
REACT:R-CEL-5690042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)
REACT:R-SSC-8864029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Sus scrofa)
RHEA:16792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + O2 <=> a 2-oxocarboxylate + H2O2
RHEA:23202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O2 + L-lysine => H2O + N(6)-methyl-L-lysine + O2
RHEA:41343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate
REACT:R-HSA-9625465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2-mediated FOS gene expression (Homo sapiens)
REACT:R-BTA-5686430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81 binds EME1, EME2 (Bos taurus)
REACT:R-SSC-167419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex releases GDP (Sus scrofa)
REACT:R-XTR-1678708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(2) (Xenopus tropicalis)
RHEA:32264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + pyruvate => L-alanine + succinate semialdehyde
REACT:R-SSC-1602368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Sus scrofa)
RHEA:24599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-histidine <=> CoA + H(+) + N(alpha)-acetyl-L-histidine
REACT:R-DME-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Drosophila melanogaster)
REACT:R-CFA-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Canis familiaris)
GO:0031679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH dehydrogenase (plastoquinone) activity
GO:0031679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH:plastoquinone reductase activity
REACT:R-HSA-9684351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pp1a cleaves itself (Homo sapiens)
REACT:R-CEL-8848606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates PXN (Caenorhabditis elegans)
REACT:R-RNO-2855054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-2 binds to molecular patterns on the target cell surface  (Rattus norvegicus)
GO:0004740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDHK
GO:0004740	skos:altLabel	"PDH kinase"
GO:0004740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0004740	skos:altLabel	"PDK"
GO:0004740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate dehydrogenase kinase activity
GO:0004740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDK
GO:0004740	skos:prefLabel	"[pyruvate dehydrogenase (acetyl-transferring)] kinase"
GO:0004740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]
GO:0004740	skos:altLabel	"pyruvate dehydrogenase kinase"
GO:0004740	skos:altLabel	"pyruvate dehydrogenase kinase (phosphorylating)"
GO:0004740	skos:altLabel	"PDHK"
GO:0004740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate dehydrogenase kinase (phosphorylating) activity
GO:0004740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDH kinase activity
GO:0004740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[pyruvate dehydrogenase (acetyl-transferring)] kinase"
REACT:R-XTR-392870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gs activation by prostacyclin receptor (Xenopus tropicalis)
RHEA:28937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
RHEA:65619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cholest-4-en-3-one + H2O <=> 25-hydroxycholest-4-en-3-one + AH2
REACT:R-BTA-2404200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2 binds IGF1R (Bos taurus)
REACT:R-MMU-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Mus musculus)
REACT:R-SSC-443418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b signaling involves c-Src (Sus scrofa)
REACT:R-HSA-6803425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds ZNF385A gene (Homo sapiens)
REACT:R-DME-377644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of CSK from SRC (Drosophila melanogaster)
REACT:R-BTA-6800299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGFAC cleaves pro-HGF to form HGF dimer (Bos taurus)
RHEA:53053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + UDP-alpha-D-glucuronate => 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:54795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[nsP1 protein]-L-histidine + N(7)-methyl-GTP <=> [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate
RHEA:18812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + oxomalonate <=> aminomalonate + pyruvate
REACT:R-BTA-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Bos taurus)
REACT:R-SPO-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Schizosaccharomyces pombe)
REACT:R-SSC-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Sus scrofa)
REACT:R-HSA-1791064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ARFGAP1 (GAP) (Homo sapiens)
REACT:R-BTA-198813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO dimers reduce DeHA to AscH- (Bos taurus)
REACT:R-CEL-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Caenorhabditis elegans)
REACT:R-SPO-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Schizosaccharomyces pombe)
REACT:R-BTA-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Bos taurus)
RHEA:65676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine
REACT:R-XTR-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Xenopus tropicalis)
RHEA:47285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-6797974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRTMs bind NRXNs (Rattus norvegicus)
RHEA:44183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-210426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamate synaptic vesicle docking and priming (Homo sapiens)
RHEA:50866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2
RHEA:61297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-alpha-D-ribose 1-phosphate => 5-deoxy-D-ribulose 1-phosphate
REACT:R-RNO-2395314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysino-5-ketonorleucine cross-links (Rattus norvegicus)
REACT:R-RNO-2473184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follistatin (FST) binds Activin (Rattus norvegicus)
GO:0102866	skos:altLabel	"Delta(5)-fatty-acid desaturase"
GO:0102866	skos:altLabel	"acyl-lipid 5-desaturase"
GO:0102866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-homo-gamma-linolenate delta5 desaturase activity
GO:0102866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0102866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0102866	skos:prefLabel	"acyl-lipid (8-3)-desaturase"
GO:0102866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid (8-3)-desaturase"
REACT:R-RNO-5651654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)
RHEA:58066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin
RHEA:26095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + limonene 1,2-epoxide + NAD(+) => (4R)-limonene + H(+) + NADH + O2
RHEA:53465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate
RHEA:49604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) = 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH
REACT:R-DME-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
REACT:R-BTA-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Bos taurus)
REACT:R-HSA-5655252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
REACT:R-DME-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Drosophila melanogaster)
RHEA:71716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-leucyl-L-leucine(out) => H(+)(in) + L-leucyl-L-leucine(in)
RHEA:52252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine
REACT:R-XTR-3858489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds DAAM1 (Xenopus tropicalis)
REACT:R-GGA-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Gallus gallus)
GO:0071858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corazonin receptor binding
REACT:R-BTA-5082384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70:DNAJB1 binds HSF1 (Bos taurus)
GO:0102817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity
RHEA:72385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) + urate(out) => Na(+)(out) + urate(in)
REACT:R-XTR-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Xenopus tropicalis)
REACT:R-SSC-171141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Sus scrofa)
RHEA:34177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxycoumarin + CO2 + 2 CoA => 2-hydroxybenzoyl-CoA + malonyl-CoA
REACT:R-HSA-2076611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3STs sulfate GlcN at C3 in heparan sulfate (Homo sapiens)
REACT:R-MMU-8948234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB:4-Hyp collagen propeptides dissociates (Mus musculus)
REACT:R-HSA-9665304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 T862A does not bind sapitinib (Homo sapiens)
REACT:R-SSC-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Sus scrofa)
REACT:R-CFA-1678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses CS/HS precursor (Canis familiaris)
REACT:R-SSC-5654659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)
RHEA:67135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH <=> (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)
REACT:R-DME-5656064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FLRT1,2,3 (Drosophila melanogaster)
REACT:R-SSC-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Sus scrofa)
REACT:R-DME-5654729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Drosophila melanogaster)
REACT:R-SSC-9605600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Sus scrofa)
RHEA:58691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + O2 + rifamycin SV <=> H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide
REACT:R-HSA-139897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAD displaces tBID from BCL-2 sequestration (Homo sapiens)
RHEA:54742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-374664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of Ezrin (Bos taurus)
RHEA:53173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)
RHEA:47395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoate ester <=> an aliphatic alcohol + H(+) + hexadecanoate
GO:0035925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA 3'-UTR adenylate/uridylate-rich element binding
GO:0035925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylate/uridylate-rich element binding
GO:0035925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ARE binding
GO:0035925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AU-rich element binding
GO:0035925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA 3'-UTR AU-rich region binding
REACT:R-SCE-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Saccharomyces cerevisiae)
REACT:R-HSA-1562604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BfrA stores iron (Homo sapiens)
GO:0046981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity
GO:0046981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity
RHEA:43320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
REACT:R-RNO-6786101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4 binds IL4R:JAK2 (Rattus norvegicus)
RHEA:24613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + NAD(+) => estrone + H(+) + NADH
REACT:R-CEL-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Caenorhabditis elegans)
REACT:R-MMU-77309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Mus musculus)
REACT:R-HSA-210837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF6-dependent synthesis of ONECUT3 protein during morphogenesis (Homo sapiens)
REACT:R-HSA-6785342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)
RHEA:31513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + CoA + H(+) => chenodeoxycholoyl-CoA + H2O
RHEA:61701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-5'-AMP + holo-[peptidyl-carrier protein] => AMP + glycyl-[peptidyl-carrier protein] + H(+)
REACT:R-HSA-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Homo sapiens)
REACT:R-MMU-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Mus musculus)
REACT:R-CFA-2328037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds integrins (Canis familiaris)
RHEA:62780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-CFA-193682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves the p75NTR transmembrane domain (Canis familiaris)
REACT:R-DME-1358798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 binds neuregulin-activated ERBB3 (Drosophila melanogaster)
REACT:R-BTA-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Bos taurus)
REACT:R-GGA-442368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
REACT:R-SSC-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Sus scrofa)
REACT:R-HSA-8848658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Homo sapiens)
REACT:R-BTA-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Bos taurus)
REACT:R-CFA-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)
REACT:R-DRE-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Danio rerio)
REACT:R-BTA-162742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Bos taurus)
GO:0001642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	group III metabotropic glutamate receptor activity
RHEA:42885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + ATP => (R)-3-phosphomevalonate + ADP + H(+)
EC:1.4.1.3	skos:altLabel	"glutamic dehydrogenase"
EC:1.4.1.3	skos:prefLabel	"glutamate dehydrogenase [NAD(P)(+)]"
EC:1.4.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate dehydrogenase [NAD(P)(+)]"
REACT:R-RNO-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Rattus norvegicus)
RHEA:38122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
RHEA:42383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O <=> 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)
REACT:R-XTR-9010872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 binds Dystroglycan (Xenopus tropicalis)
RHEA:51875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + umbelliferone <=> diphosphate + osthenol
GO:0035488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine/thymine mispair binding
GO:0035488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine/cytosine mispair binding
GO:0035488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T/C mispair binding
GO:0035488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C/T mispair binding
RHEA:71396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) => (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)
REACT:R-DRE-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Danio rerio)
REACT:R-RNO-2993447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6x(PCCA:PCCB) (Rattus norvegicus)
RHEA:59605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermidine => H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)
REACT:R-MMU-1169405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein phosphatase 1 beta (PP2CB) (Mus musculus)
REACT:R-GGA-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Gallus gallus)
EC:1.3.7.8	skos:prefLabel	"benzoyl-CoA reductase"
EC:1.3.7.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzoyl-CoA reductase"
REACT:R-DRE-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)
REACT:R-BTA-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Bos taurus)
RHEA:25136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + pyridoxamine => H2O + pyridoxamine 5'-phosphate
RHEA:10578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-N-methylethanolamine + diphosphate => CTP + H(+) + N-methylethanolamine phosphate
RHEA:43074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:29719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(I)alamin(in) = cob(I)alamin(out)
GO:0015593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allose transmembrane transporter activity
REACT:R-DRE-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Danio rerio)
REACT:R-SPO-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Schizosaccharomyces pombe)
REACT:R-DDI-5649734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates NEIL1,NEIL2-generated single strand break (Dictyostelium discoideum)
RHEA:23859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Hg + NADP(+) <=> Hg(2+) + NADPH
RHEA:67513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-RNO-8869667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxLDL:CD36 binds TLR4:TLR6 (Rattus norvegicus)
REACT:R-CFA-2534346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAM1 Binds Hyaluronic Acid (Canis familiaris)
RHEA:44322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoate + glycerol + H(+) => 1-decanoylglycerol + H2O
RHEA:54717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-DME-193369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Drosophila melanogaster)
RHEA:54423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-AMP + H2O <=> 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)
REACT:R-MMU-9697750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)
RHEA:16102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)
RHEA:17187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH4(+)
RHEA:46906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate)
REACT:R-XTR-9757706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Xenopus tropicalis)
RHEA:34708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane
REACT:R-MMU-8853801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPN binds RET:GFRA4 (Mus musculus)
REACT:R-DRE-8957265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades TP73 polyubiquitinated by ITCH (Danio rerio)
RHEA:59867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoate + ATP + L-glutamine <=> (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)
RHEA:66034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose
REACT:R-DDI-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Dictyostelium discoideum)
REACT:R-BTA-6799196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)
REACT:R-GGA-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Gallus gallus)
REACT:R-CEL-2179413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC-alpha  activate MMP3 (Caenorhabditis elegans)
GO:0031868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostanoid FP receptor binding
GO:0031868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin F2-alpha receptor binding
GO:0031868	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	prostaglandin F2-alpha receptor ligand
REACT:R-CFA-507719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62:MEKK3 binds to TRAF6 (Canis familiaris)
REACT:R-DRE-74718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalisation of the insulin receptor (Danio rerio)
REACT:R-XTR-5578965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A binds AGO2:miRNA (Xenopus tropicalis)
REACT:R-DRE-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Danio rerio)
RHEA:32369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate => 4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone
RHEA:53259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:65561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-kynurenine => H2O + kynurenate + L-glutamate
REACT:R-BTA-173709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C7 binds C5b:C6 (Bos taurus)
REACT:R-GGA-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Gallus gallus)
REACT:R-XTR-8848776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates DOK1 (Xenopus tropicalis)
REACT:R-HSA-216727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Homo sapiens)
REACT:R-HSA-9665406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 (Homo sapiens)
RHEA:42005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH
REACT:R-XTR-4570463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Xenopus tropicalis)
RHEA:63163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)-taurine <=> (15Z)-tetracosenoate + taurine
RHEA:67315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> myceliothermophin E
REACT:R-MMU-1112514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK activation (Mus musculus)
RHEA:66467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O <=> scalarane-17alpha-19-diol
REACT:R-HSA-8961620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the CDC6 gene promoter (Homo sapiens)
REACT:R-MMU-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Mus musculus)
REACT:R-SSC-9007926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATRX binds DAXX (Sus scrofa)
REACT:R-HSA-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Homo sapiens)
REACT:R-HSA-9032582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FYN binds GRIN2B (Homo sapiens)
REACT:R-GGA-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Gallus gallus)
RHEA:41861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydecanoyl-[ACP] => (2E)-decenoyl-[ACP] + H2O
REACT:R-CFA-8944223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type V (Canis familiaris)
REACT:R-CFA-2187325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 ADP-ribosylates SMAD3 and SMAD4 (Canis familiaris)
RHEA:20951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfopyruvate + H(+) <=> CO2 + sulfoacetaldehyde
REACT:R-GGA-2029458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)
REACT:R-BTA-420595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-2:Nectin 3 trans heterodimer interaction (Bos taurus)
REACT:R-BTA-77327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Bos taurus)
RHEA:31809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-RNO-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Rattus norvegicus)
GO:0033442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine tRNA
GO:0033442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAC codon-amino acid adaptor activity
RHEA:43219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine <=> (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-9028263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGJ3 isomerises to δ12-PGJ3 (Homo sapiens)
REACT:R-DME-8938930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF2 (Drosophila melanogaster)
EC:6.1.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Cyclo-ligases"
EC:6.1.3.-	skos:prefLabel	"Cyclo-ligases"
REACT:R-MMU-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Mus musculus)
REACT:R-SSC-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Sus scrofa)
REACT:R-HSA-9629492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves spiroiminodihydantoin (Homo sapiens)
REACT:R-XTR-1306876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 activation by small molecules (Xenopus tropicalis)
REACT:R-MMU-390598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Mus musculus)
RHEA:52127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Bos taurus)
GO:0008139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear localisation sequence binding
GO:0008139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLS binding
GO:0008139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear localization sequence binding
GO:0008139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear localization signal binding
RHEA:56231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-SSC-8940074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NMN (Sus scrofa)
REACT:R-MMU-9708525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)
RHEA:56670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)
RHEA:26196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + ATP + CoA <=> (S)-malyl-CoA + ADP + phosphate
REACT:R-GGA-1470012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus (Gallus gallus)
RHEA:11293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + rifamycin B => H2O2 + rifamycin O
REACT:R-XTR-8948232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Xenopus tropicalis)
REACT:R-CFA-8874080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates PTK2 (Canis familiaris)
REACT:R-DME-9674127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
REACT:R-CEL-6814418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes formation of G-beta:G-gamma heterodimers (Caenorhabditis elegans)
REACT:R-GGA-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Gallus gallus)
REACT:R-CFA-201425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Canis familiaris)
RHEA:47519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isochenodeoxycholate + NAD(+)
REACT:R-BTA-2065549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Bos taurus)
RHEA:67355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + rhaponticin <=> 6-O-malonyl-rhaponticin + CoA
REACT:R-HSA-6783552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM binds LIFR:JAKs,OSMR:JAKs (Homo sapiens)
RHEA:37436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
REACT:R-SSC-73806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIR + CO2 => CAIR (Sus scrofa)
RHEA:24358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-HSA-6797957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET translocates from mitochondrial matrix to cytosol (Homo sapiens)
REACT:R-HSA-9012761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI binds RHOA-GDI (Homo sapiens)
RHEA:48298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + prostaglandin E2 => H2O + prostaglandin E2 1-glyceryl ester
RHEA:28372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate + phosphoenolpyruvate => oxaloacetate + phosphate
REACT:R-BTA-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Bos taurus)
RHEA:39631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH = (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)
REACT:R-DRE-6805122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB binds TP53 (Danio rerio)
REACT:R-SPO-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Schizosaccharomyces pombe)
RHEA:54122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine h dioxetanone => coelenterazine h + O2
REACT:R-BTA-9691621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5 binds C5 inhibitors (Bos taurus)
REACT:R-RNO-391168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP gamma binds CD47 (Rattus norvegicus)
REACT:R-CFA-5654407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates SHC1 (Canis familiaris)
REACT:R-HSA-5244415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface (Homo sapiens)
RHEA:15680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanamide + H2O <=> 5-aminopentanoate + NH4(+)
RHEA:61173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP
RHEA:14134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-421222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ (Gallus gallus)
REACT:R-MMU-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Mus musculus)
REACT:R-BTA-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Bos taurus)
RHEA:55714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O
REACT:R-DRE-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Danio rerio)
RHEA:28821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate(out) + H(+)(out) => 5-dehydro-D-gluconate(in) + H(+)(in)
REACT:R-BTA-9769235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGED1 binds NPAS4 (Bos taurus)
RHEA:19423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1,2-epoxypropane + coenzyme M => (R)-2-hydroxypropyl-coenzyme M
RHEA:52650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-L-arabinonate + H(+) => H2O + L-arabino-1,4-lactone 5-phosphate
REACT:R-MMU-5656064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FLRT1,2,3 (Mus musculus)
REACT:R-MMU-209840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two DITs combine to form thyroxine (Mus musculus)
RHEA:47697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate
REACT:R-HSA-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Homo sapiens)
REACT:R-CFA-380942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LKB1 forms a trimeric complex with STRAD and MO25 (Canis familiaris)
REACT:R-RNO-5675947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF18 binds TNFRSF18 (Rattus norvegicus)
RHEA:12751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trihydroxybenzene + CO2 => 3,4,5-trihydroxybenzoate + H(+)
RHEA:35228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + rifampicin(in) => H(+)(in) + rifampicin(out)
REACT:R-HSA-8986939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the NCoR/SMRT complex (Homo sapiens)
REACT:R-BTA-430135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds ADAP (Bos taurus)
REACT:R-MMU-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Mus musculus)
REACT:R-SSC-2161961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EET(1) is hydrolysed to DHET(1) by EPHX2 (Sus scrofa)
RHEA:67273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)
RHEA:27554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate <=> di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate
REACT:R-XTR-374214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CXCR4 and 7 bind CXCL12 ligand (Xenopus tropicalis)
GO:0036397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate dehydrogenase-N activity
GO:0036397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate dehydrogenase (quinone) activity
GO:0036397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate:quinone oxidoreductase activity
GO:0036397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Fdh-N activity
RHEA:21136	skos:altLabel	"carnitine acetylase"
RHEA:21136	skos:prefLabel	"carnitine O-acetyltransferase"
RHEA:21136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnitine O-acetyltransferase"
RHEA:21136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine
REACT:R-RNO-158300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Rattus norvegicus)
RHEA:23727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pyridoxal <=> 4-pyridoxate + H(+) + H2O2
REACT:R-MMU-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Mus musculus)
REACT:R-GGA-3322422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits SMARCA4 (Gallus gallus)
RHEA:10368	skos:prefLabel	"dTDP-4-amino-4,6-dideoxygalactose transaminase"
RHEA:10368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
RHEA:10368	skos:altLabel	"dTDP-4-amino-4,6-dideoxygalactose aminotransferase"
RHEA:10368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-amino-4,6-dideoxygalactose transaminase"
REACT:R-HSA-193143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates TEST to EST17b (Homo sapiens)
REACT:R-DRE-9021660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds membrane-associated estrogen receptors (Danio rerio)
RHEA:32806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + urea(out) <=> ADP + H(+) + phosphate + urea(in)
RHEA:13356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)
REACT:R-DRE-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Danio rerio)
RHEA:41009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-linalyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin
REACT:R-HSA-1483197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPMT1 dephosphorylates PGP to PG (Homo sapiens)
REACT:R-HSA-1497824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle (Homo sapiens)
REACT:R-BTA-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Bos taurus)
REACT:R-GGA-5682586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 and PIAS4 are recruited to DNA DSBs (Gallus gallus)
RHEA:47280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5690196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates RNF128 (Sus scrofa)
RHEA:45554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine => H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:20977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary nitroalkane + H2O + O2 => an aldehyde + H(+) + H2O2 + nitrite
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2:FMN oxidoreductase activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH dehydrogenase (FMN) activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NAD(+) = FMN + 2 H(+) + NADH
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH(2):FMN oxidoreductase activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:FMN oxidoreductase activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dependent FMN reductase activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2 dehydrogenase (FMN)
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	flavine mononucleotide reductase activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMNH2:NAD+ oxidoreductase activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SsuE
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-FMN reductase activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	flavin mononucleotide reductase activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:flavin oxidoreductase activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH(2) dehydrogenase (FMN) activity
GO:0052874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN reductase (NADH) activity
REACT:R-DME-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)
RHEA:21986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + choline sulfate + H(+) => 3'-phosphoadenylyl sulfate + choline
RHEA:12801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein]
REACT:R-MMU-389826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NADPH + H+ => glycolate + NADP+ (Mus musculus)
RHEA:61491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(50) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:12144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-rutinoside + UDP-alpha-D-glucose = cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP
RHEA:51832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)
GO:0008330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine/threonine phosphatase activity
REACT:R-DRE-8944219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVI (Danio rerio)
RHEA:22595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate <=> (10Z,15Z)-12-oxophytodienoate
RHEA:49291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)
RHEA:27892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + uridine => 3'-UMP + H2O
GO:0008186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent activity, acting on RNA
GO:0008186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase activity, acting on RNA
GO:0008186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-dependent ATPase activity
GO:0008186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase, acting on RNA
GO:0008186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-dependent adenosinetriphosphatase activity
RHEA:71883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide
GO:0050700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD domain binding
RHEA:33066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]
GO:0052763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ulvan lyase activity
REACT:R-HSA-9036102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)
RHEA:38807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DRE-448632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimerizes (Danio rerio)
RHEA:30263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + 2 L-ascorbate = 2 H2O + 2 monodehydro-L-ascorbate radical
REACT:R-DDI-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Dictyostelium discoideum)
REACT:R-HSA-202500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of IKK complex (Homo sapiens)
RHEA:58354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2
REACT:R-RNO-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Rattus norvegicus)
RHEA:39385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH
RHEA:46406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-RNO-9018880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Rattus norvegicus)
REACT:R-MMU-937029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)
REACT:R-RNO-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Rattus norvegicus)
REACT:R-XTR-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Xenopus tropicalis)
REACT:R-BTA-211962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F11 16-hydroxylates 3OH-PALM (Bos taurus)
RHEA:22155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + D-glucose <=> a ubiquinol + D-glucono-1,5-lactone
REACT:R-MMU-9020282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Mus musculus)
REACT:R-CFA-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Canis familiaris)
RHEA:19614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + trimethylsulfonium
RHEA:31094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dodecanoyl-CoA <=> 3-oxotetradecanoyl-CoA + CoA
REACT:R-MMU-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Mus musculus)
REACT:R-DME-9638075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from DS (Drosophila melanogaster)
REACT:R-MMU-6805205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR35 binds kynurenic acid (Mus musculus)
RHEA:30640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)
RHEA:24741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
REACT:R-DDI-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Dictyostelium discoideum)
RHEA:43787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine
REACT:R-MMU-1170539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor is internalized (Mus musculus)
RHEA:55096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxypentanoyl-CoA + H2O = (3S)-3-hydroxypentanoate + CoA + H(+)
REACT:R-HSA-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)
RHEA:28111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + S-adenosyl-L-methionine => 5'-chloro-5'-deoxyadenosine + L-methionine
RHEA:67701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)
REACT:R-DRE-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Danio rerio)
REACT:R-MMU-388605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMC(138-176) binds MC2R (Mus musculus)
REACT:R-HSA-164522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Terminal (3' end) cleavage of viral DNA (Homo sapiens)
REACT:R-BTA-936991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Bos taurus)
RHEA:12952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fuconate <=> 2-dehydro-3-deoxy-D-fuconate + H2O
REACT:R-SPO-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Schizosaccharomyces pombe)
RHEA:55376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a quinol + O2 = 2 a quinone + 2 H2O
RHEA:69180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + thiamine diphosphate = AMP + thiamine triphosphate
RHEA:15546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalate => acetate + pyruvate
RHEA:21099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate <=> 3-dehydroshikimate + H2O
RHEA:31456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + reduced riboflavin => 2 H(+) + NADH + riboflavin
REACT:R-HSA-113402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:early elongation complex (Homo sapiens)
REACT:R-MMU-352182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Mus musculus)
REACT:R-DRE-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Danio rerio)
REACT:R-HSA-9703438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 fusions phosphorylate GAB2 (Homo sapiens)
RHEA:24134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactofuranose => UDP-alpha-D-galactose
REACT:R-HSA-170847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
REACT:R-DRE-9690449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 bind S1P (Danio rerio)
RHEA:41811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoyl-[ACP] <=> (2E)-butenoyl-[ACP] + H2O
GO:0047062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-1,2-acenaphthenediol dehydrogenase activity
GO:0047062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-acenaphthene-1,2-diol dehydrogenase activity
GO:0047062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity
RHEA:48146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine
RHEA:50054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + taurocholate(out) => ATP + H2O + taurocholate(in)
REACT:R-SSC-2065550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds Importin beta-1 (Sus scrofa)
REACT:R-RNO-428609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type I Na+-coupled phosphate co-transport (Rattus norvegicus)
RHEA:35684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecasphinganine + NADP(+) => 3-oxohexadecasphinganine + H(+) + NADPH
EC:3.2.1.85	skos:altLabel	"beta-D-phosphogalactoside galactohydrolase"
EC:3.2.1.85	skos:prefLabel	"6-phospho-beta-galactosidase"
EC:3.2.1.85	skos:altLabel	"6-Phospho-beta-D-galactosidase"
EC:3.2.1.85	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-phospho-beta-galactosidase"
RHEA:37601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2
GO:0098632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein binding involved in cell-cell adhesion
GO:0098632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell-cell adhesion mediator activity
GO:0098632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell-cell adhesion molecule
REACT:R-DME-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Drosophila melanogaster)
REACT:R-BTA-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Bos taurus)
REACT:R-CEL-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)
RHEA:36935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:23030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein]
RHEA:37177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA
RHEA:35123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-D-glutamate(out) = H(+)(in) + L-alanyl-D-glutamate(in)
REACT:R-SCE-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Saccharomyces cerevisiae)
RHEA:52479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + UDP-alpha-D-glucuronate <=> estrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-BTA-8955844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBKS phosphorylates ribose to R5P (Bos taurus)
RHEA:68322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,5-bisphosphate + phosphate => 1D-myo-inositol 2,4,5-triphosphate + H2O
GO:0034869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity
RHEA:25795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Cu(+)(in) + H2O <=> ADP + Cu(+)(out) + H(+) + phosphate
RHEA:65379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-MMU-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Mus musculus)
RHEA:70049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-2-aminoadipate => 2-oxoadipate + L-kynurenine
RHEA:56891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-dehydro-6-deoxy-alpha-D-glucose <=> UDP-4-dehydro-beta-L-rhamnose
REACT:R-DRE-182990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty sequesters CBL away from active EGFR (Danio rerio)
REACT:R-BTA-2509793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses dIDP to dIMP (Bos taurus)
REACT:R-RNO-8866327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL translocates from SER lumen to extracellular region (Rattus norvegicus)
RHEA:63449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + CTP => CMP-(2-aminoethyl)phosphonate + diphosphate
REACT:R-CFA-8944257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIV (Canis familiaris)
RHEA:16604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate <=> fumarate + NH4(+)
RHEA:34682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + methylphosphonate <=> adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate
REACT:R-DDI-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)
RHEA:70312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
EC:1.14.14.89	skos:prefLabel	"4'-methoxyisoflavone 2'-hydroxylase"
EC:1.14.14.89	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4'-methoxyisoflavone 2'-hydroxylase"
EC:1.14.14.89	skos:altLabel	"CYP81E7"
EC:1.14.14.89	skos:altLabel	"CYP81E1"
EC:1.14.14.89	skos:altLabel	"CYP81E3"
EC:1.14.14.89	skos:altLabel	"isoflavone 2'-monooxygenase"
EC:1.14.14.89	skos:altLabel	"isoflavone 2'-hydroxylase"
RHEA:58648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifamycin SV hemiaminal = H(+) + rifamycin SV ortho-naphthoquinone carboxamide
REACT:R-DRE-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Danio rerio)
RHEA:34633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin]
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-glucocerebrosidase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ceramide glucosidase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucocerebrosidase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucosyl-N-acylsphingosine glucohydrolase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosphingosine glucosylhydrolase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosylsphingosine beta-D-glucosidase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosylsphingosine beta-glucosidase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	psychosine hydrolase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glucocerebrosidase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid beta-glucosidase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcCer-beta-glucosidase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosylceramidase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosylcerebrosidase activity
GO:0004348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glucosylceramidase activity
RHEA:42695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate <=> [(1->4)-alpha-D-glucosyl](n+2) + phosphate
REACT:R-RNO-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Rattus norvegicus)
RHEA:54033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)
RHEA:27611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) => CO2 + H2
RHEA:57447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine
REACT:R-DRE-1250357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds P-ERBB4 isoform dimers (Danio rerio)
REACT:R-HSA-8982641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Homo sapiens)
RHEA:58494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Fe(III)-enterobactin(in) + H(+) + phosphate => ATP + Fe(III)-enterobactin(out) + H2O
REACT:R-GGA-430158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds VAV (Gallus gallus)
RHEA:30142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanoyl-CoA <=> CoA + H(+) + octadecanoate
REACT:R-DRE-1605632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Both hexosaminidase A and B can cleave GalNAc from globoside (Danio rerio)
RHEA:61268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminohexanoate + O2 = 2-oxohexanoate + H2O2 + NH4(+)
REACT:R-RNO-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)
RHEA:16711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2
REACT:R-DME-5656105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Drosophila melanogaster)
REACT:R-SSC-9670673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIX is secreted (Sus scrofa)
REACT:R-PFA-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Plasmodium falciparum)
REACT:R-MMU-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Mus musculus)
GO:0102762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eriodictyol 4'-O-methyltransferase activity
RHEA:37116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-sphing-4-enine
REACT:R-CFA-5638141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)
RHEA:34113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine => carboxyspermidine + H2O + NADP(+)
RHEA:58736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + TTP = 5-methyl-UMP + diphosphate + H(+)
REACT:R-DRE-741411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates NEMO (Danio rerio)
REACT:R-BTA-2981040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC12:ligand is endocytosed (Bos taurus)
REACT:R-BTA-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Bos taurus)
RHEA:55770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-retinoate + UDP-alpha-D-glucuronate
RHEA:38618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic ADP-beta-D-ribose + H2O <=> ADP-D-ribose
RHEA:52820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + succinyl-CoA = CoA + O-succinyl-L-serine
GO:0008786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allose 6-phosphate isomerase activity
REACT:R-BTA-1861595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extension of pseudopodia by myosin-X in a PI3K dependent manner (Bos taurus)
REACT:R-BTA-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Bos taurus)
REACT:R-DRE-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Danio rerio)
RHEA:49051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Rattus norvegicus)
RHEA:36764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-XTR-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Xenopus tropicalis)
REACT:R-XTR-388831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CD28 (Xenopus tropicalis)
RHEA:64161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide => ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]
REACT:R-CFA-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Canis familiaris)
RHEA:44964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H(+) + NADPH = dodecanoyl-CoA + NADP(+)
GO:0052912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23S rRNA (guanine(748)-N(1))-methyltransferase activity
GO:0052912	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	23S rRNA m(1)G(748) methyltransferase activity
REACT:R-XTR-159762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)
REACT:R-RNO-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Rattus norvegicus)
RHEA:56059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein + UDP-alpha-D-glucose <=> genistein 7-O-beta-D-glucoside + H(+) + UDP
RHEA:19654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH
REACT:R-XTR-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Xenopus tropicalis)
REACT:R-CFA-193679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-secretase cleaves the p75NTR extracellular domain (Canis familiaris)
RHEA:38771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-2972949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter (Homo sapiens)
REACT:R-SSC-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)
REACT:R-CFA-975147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Canis familiaris)
RHEA:40107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-DME-8952419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs ubiquitinate RUNX3 (Drosophila melanogaster)
RHEA:12463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate <=> fumarate + H2O
REACT:R-MMU-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Mus musculus)
RHEA:44394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA
REACT:R-HSA-428535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by SOS (Homo sapiens)
REACT:R-CFA-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Canis familiaris)
REACT:R-CFA-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Canis familiaris)
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN reductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SsuE
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	riboflavin mononucleotide reductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	riboflavine mononucleotide reductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H-dependent FMN reductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)H dehydrogenase (FMN) activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H-FMN reductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMNH2:NAD(P)+ oxidoreductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H2 dehydrogenase (FMN)
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H(2) dehydrogenase (FMN) activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:FMN oxidoreductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavine mononucleotide reductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin mononucleotide reductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H2:FMN oxidoreductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:flavin oxidoreductase activity
GO:0008752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H(2):FMN oxidoreductase activity
RHEA:16412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydrovomilenine + NADP(+) <=> H(+) + NADPH + vomilenine
RHEA:58429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-2,4-hexadien-1-ol + NADP(+) => (E,E)-2,4-hexadienal + H(+) + NADPH
REACT:R-CFA-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Canis familiaris)
RHEA:55620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carotenoid psi-end group = a carotenoid beta-end derivative
REACT:R-HSA-5674496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate MAP2K1 (Homo sapiens)
RHEA:15601	skos:altLabel	"FldA"
RHEA:15601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase"
RHEA:15601	skos:prefLabel	"3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase"
RHEA:15601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA + (R)-3-phenyllactate = (E)-cinnamate + (R)-3-phenyllactoyl-CoA
REACT:R-SSC-8938121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds CTSK (Sus scrofa)
RHEA:13138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloartenol + S-adenosyl-L-methionine => cyclolaudenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-2160931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of tight junctions (Homo sapiens)
RHEA:65937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose => beta-D-glucose
GO:0047282	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity
GO:0047282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity
GO:0047282	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity
GO:0047282	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity
RHEA:52464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-HSA-166363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to hp- IRAK1 (Homo sapiens)
REACT:R-DDI-5620975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PIPs (Dictyostelium discoideum)
REACT:R-BTA-5666160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates DIAPH2-2 at kinetochores (Bos taurus)
RHEA:65284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)
RHEA:41323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-DDI-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Dictyostelium discoideum)
RHEA:67217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA => (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O
REACT:R-HSA-2428922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Homo sapiens)
REACT:R-MMU-199299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO transcription factors (Mus musculus)
RHEA:24438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromethanophenazine => H2 + methanophenazine
REACT:R-CEL-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)
REACT:R-DRE-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Danio rerio)
REACT:R-BTA-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Bos taurus)
RHEA:65759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] <=> (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]
REACT:R-HSA-5244428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
RHEA:71758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + 2-oxoheptanedioate(in) <=> 2-oxoglutarate(in) + 2-oxoheptanedioate(out)
REACT:R-BTA-6810392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMEM55B translocates to the nucleus (Bos taurus)
REACT:R-HSA-1614461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetramerization of procollagen VI (Homo sapiens)
REACT:R-HSA-6813659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE, CTSG or PRTN3 binds bacteria (Homo sapiens)
REACT:R-HSA-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)
REACT:R-CEL-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Caenorhabditis elegans)
RHEA:19374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NADP(+) => 2-oxoglutarate + H(+) + L-lysine + NADPH
REACT:R-DRE-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Danio rerio)
REACT:R-RNO-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Rattus norvegicus)
REACT:R-DME-77309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Drosophila melanogaster)
REACT:R-DME-71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)
REACT:R-SPO-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Schizosaccharomyces pombe)
REACT:R-XTR-5610766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Xenopus tropicalis)
RHEA:47461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(5Z-tetradecenoyl)-CoA + CoA => (3Z)-dodecenoyl-CoA + acetyl-CoA
REACT:R-PFA-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Plasmodium falciparum)
REACT:R-MMU-5694410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMED2:TMED10 tetramer binds GPI anchored proteins (Mus musculus)
REACT:R-HSA-6786101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4 binds IL4R:JAK2 (Homo sapiens)
RHEA:54222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-neurosporene + H2O => 1-hydroxy-all-trans-1,2-dihydro-neurosporene
RHEA:71385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(out) + Na(+)(out) => L-asparagine(in) + Na(+)(in)
RHEA:49362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2'-dioxospirilloxanthin + H2O => 2',2'-dihydroxy-2-oxospirilloxanthin
REACT:R-DRE-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
RHEA:58629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV => FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal
REACT:R-MMU-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Mus musculus)
REACT:R-MMU-453200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Mus musculus)
REACT:R-BTA-8848338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes TAG (Bos taurus)
REACT:R-HSA-9683663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-glycan trimming of Spike (Homo sapiens)
REACT:R-BTA-8853745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA3 (Bos taurus)
RHEA:21508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + H2O = H(+) + hexadecanoate + retinol
RHEA:47275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoanhydrobacterioruberin <=> bisanhydrobacterioruberin + H2O
REACT:R-CFA-391375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Canis familiaris)
REACT:R-SSC-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Sus scrofa)
RHEA:23746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate => 2-oxoglutarate + L-histidinol phosphate
REACT:R-RNO-159733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor X to factor X (Rattus norvegicus)
RHEA:32038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)
REACT:R-HSA-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)
REACT:R-BTA-8870732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSGs bind proteoglycans and TGF-beta1 (Bos taurus)
EC:3.4.21.84	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limulus clotting factor C"
EC:3.4.21.84	skos:prefLabel	"limulus clotting factor C"
EC:1.23.-.-	skos:prefLabel	"Reducing C-O-C group as acceptor"
EC:1.23.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Reducing C-O-C group as acceptor"
RHEA:31870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> baccharis oxide
RHEA:61244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan + O2 = H2O2 + indole-3-pyruvate + NH4(+)
RHEA:55578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + psilocybin + S-adenosyl-L-homocysteine => 4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine
REACT:R-CFA-446684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Canis familiaris)
RHEA:26071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O <=> CoA + H(+) + phosphinomethylmalate
GO:0000401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	open form Holliday junction binding
GO:0000401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	open form four-way junction DNA binding
REACT:R-XTR-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Xenopus tropicalis)
REACT:R-DME-5626316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Drosophila melanogaster)
RHEA:46935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone 7-phosphate <=> 5-epi-valiolone 7-phosphate
REACT:R-CFA-1237081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Canis familiaris)
REACT:R-CEL-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)
REACT:R-BTA-68918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)
GO:0035410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrotestosterone 17-beta-dehydrogenase activity
REACT:R-MMU-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Mus musculus)
REACT:R-CFA-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Canis familiaris)
REACT:R-HSA-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)
REACT:R-HSA-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Homo sapiens)
REACT:R-DRE-9020264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Danio rerio)
REACT:R-HSA-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Homo sapiens)
REACT:R-SSC-5635842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3 phosphorylates GLI (Sus scrofa)
REACT:R-RNO-1614336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Rattus norvegicus)
RHEA:43763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]
REACT:R-DDI-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Dictyostelium discoideum)
RHEA:58381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + nonan-1-ol => H(+) + NADPH + nonanal
RHEA:52469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-MMU-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Mus musculus)
REACT:R-RNO-264435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the COP1-p53 complex (Rattus norvegicus)
REACT:R-MMU-8964241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)
REACT:R-CEL-211178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO1A is excluded from the nucleus (Caenorhabditis elegans)
REACT:R-CEL-199299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO transcription factors (Caenorhabditis elegans)
REACT:R-HSA-9665525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sCD163 translocates from extracellular region to cytosol (Homo sapiens)
REACT:R-HSA-8849102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRMS phosphorylates PTK6 (Homo sapiens)
REACT:R-RNO-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Rattus norvegicus)
REACT:R-GGA-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Gallus gallus)
RHEA:30787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine
REACT:R-HSA-8986943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds MET gene promoter (Homo sapiens)
REACT:R-SSC-8940070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NAD+ (Sus scrofa)
REACT:R-CFA-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)
EC:4.2.2.5	skos:altLabel	"chondroitinase"
EC:4.2.2.5	skos:prefLabel	"chondroitin AC lyase"
EC:4.2.2.5	skos:altLabel	"chondroitin sulfate lyase"
EC:4.2.2.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chondroitin AC lyase"
EC:4.2.2.5	skos:altLabel	"chondroitin AC eliminase"
RHEA:31068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-2-oxohexanoate => Delta(1)-piperideine-2-carboxylate + H2O
RHEA:17653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
RHEA:17653	skos:altLabel	"geranylgeranyl-PP synthetase"
RHEA:17653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranylgeranyl diphosphate synthase"
RHEA:17653	skos:altLabel	"farnesyltranstransferase"
RHEA:17653	skos:altLabel	"geranylgeranyl pyrophosphate synthetase"
RHEA:17653	skos:prefLabel	"geranylgeranyl diphosphate synthase"
RHEA:17653	skos:altLabel	"geranylgeranyl pyrophosphate synthase"
RHEA:17653	skos:altLabel	"geranylgeranyl-diphosphate synthase"
RHEA:17653	skos:altLabel	"farnesyltransferase"
REACT:R-DRE-8951499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides on to class I MHC (Danio rerio)
REACT:R-DRE-166271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Danio rerio)
RHEA:30451	skos:prefLabel	"isomultiflorenol synthase"
RHEA:30451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isomultiflorenol synthase"
RHEA:30451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = isomultiflorenol
REACT:R-DRE-204169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP dephosphorylates p-lipo-PDH (Danio rerio)
REACT:R-XTR-5624953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL13B binds INPP5E (Xenopus tropicalis)
GO:0050015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KHase activity
GO:0050015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kievitone hydratase activity
GO:0050015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kievitone-hydrate hydro-lyase (kievitone-forming)
GO:0050015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kievitone-hydrate hydro-lyase activity
REACT:R-RNO-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Rattus norvegicus)
REACT:R-DRE-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Danio rerio)
GO:0047661	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-amino acid racemase activity
GO:0047661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino-acid racemase activity
REACT:R-HSA-188345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
GO:0052678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl-diphosphate diphosphate-lyase [ent-abieta-8(14),12-diene-forming] activity
GO:0052678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	levopimaradiene synthase activity
REACT:R-SSC-2130504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of lip22 to lip10 (Sus scrofa)
REACT:R-DME-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
RHEA:19189	skos:altLabel	"pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating)"
RHEA:19189	skos:altLabel	"pyruvate dehydrogenase complex"
RHEA:19189	skos:altLabel	"pyruvic dehydrogenase"
RHEA:19189	skos:altLabel	"pyruvic acid dehydrogenase"
RHEA:19189	skos:altLabel	"pyruvate dehydrogenase (lipoamide)"
RHEA:19189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate dehydrogenase (acetyl-transferring)"
RHEA:19189	skos:altLabel	"pyruvate decarboxylase"
RHEA:19189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2
RHEA:19189	skos:altLabel	"pyruvate dehydrogenase"
RHEA:19189	skos:prefLabel	"pyruvate dehydrogenase (acetyl-transferring)"
RHEA:14511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-epihydroxymugineate + CO2 + H(+) + succinate => 2-oxoglutarate + mugineate + O2
REACT:R-DME-1369052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid influx (Drosophila melanogaster)
RHEA:29965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + inosine(out) => H(+)(in) + inosine(in)
REACT:R-SSC-3465429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(S) and procaspase-8 form heterodimer (Sus scrofa)
REACT:R-CFA-9020264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Canis familiaris)
REACT:R-BTA-400097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-beta:G-gamma inhibits Adenylate cyclase (Bos taurus)
REACT:R-HSA-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Homo sapiens)
REACT:R-BTA-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Bos taurus)
RHEA:60561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionyl-[protein] + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]
REACT:R-RNO-373734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin interacts with Podocin (Rattus norvegicus)
RHEA:36685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + S-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-cysteinyl-[protein]
RHEA:48105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
RHEA:60675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + nerol <=> H(+) + NADH + neral
REACT:R-HSA-202165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
REACT:R-BTA-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Bos taurus)
RHEA:66059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan
REACT:R-MMU-482770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet secretory granule components (Mus musculus)
REACT:R-BTA-2029268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of PLCG (Bos taurus)
REACT:R-HSA-6803935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the PLAGL1 gene (Homo sapiens)
RHEA:62022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + sitosterol => H2O + sitosteryl 3-beta-D-glucoside
GO:0071160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanophycin synthetase activity (L-aspartate-adding)
REACT:R-SPO-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Schizosaccharomyces pombe)
REACT:R-RNO-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Rattus norvegicus)
GO:0033430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGC codon-amino acid adaptor activity
GO:0033430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine tRNA
RHEA:28065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
REACT:R-GGA-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Gallus gallus)
EC:3.4.23.26	skos:prefLabel	"rhodotorulapepsin"
EC:3.4.23.26	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhodotorulapepsin"
EC:3.4.23.26	skos:altLabel	"Rhodotorula aspartic proteinase"
REACT:R-HSA-6798257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRS binds NTRK3 (Homo sapiens)
REACT:R-SSC-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Sus scrofa)
REACT:R-HSA-114697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Homo sapiens)
REACT:R-MMU-6787677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUOM isomerises alpha-Fuc to beta-Fuc (Mus musculus)
REACT:R-DDI-83723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Dictyostelium discoideum)
REACT:R-SPO-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Schizosaccharomyces pombe)
RHEA:35146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA
REACT:R-HSA-2327886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLRPs bind TGF Beta (Homo sapiens)
REACT:R-BTA-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Bos taurus)
RHEA:40911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-MMU-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Mus musculus)
REACT:R-HSA-9617067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Homo sapiens)
REACT:R-HSA-350147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 translocates from extracellular region to ER membrane (Homo sapiens)
REACT:R-DDI-8950778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dimerizes (Dictyostelium discoideum)
RHEA:18089	skos:altLabel	"PAD"
RHEA:18089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+)
RHEA:18089	skos:prefLabel	"protein-arginine deiminase"
RHEA:18089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-arginine deiminase"
RHEA:16240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-peptidylproline (omega=180) <=> [protein]-peptidylproline (omega=0)
REACT:R-RNO-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Rattus norvegicus)
REACT:R-XTR-4615873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates SUZ12 with SUMO1 (Xenopus tropicalis)
RHEA:72811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)
RHEA:37401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
RHEA:50067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurochenodeoxycholate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate(out)
RHEA:56232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate
RHEA:56232	skos:altLabel	"exopolygalacturanosidase"
RHEA:56232	skos:altLabel	"exo-poly-alpha-galacturonosidase"
RHEA:56232	skos:prefLabel	"exo-poly-alpha-digalacturonosidase"
RHEA:56232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exo-poly-alpha-digalacturonosidase"
REACT:R-GGA-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Gallus gallus)
REACT:R-BTA-8847579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)
REACT:R-MMU-1067667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R (Mus musculus)
RHEA:72336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate => 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
REACT:R-HSA-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Homo sapiens)
RHEA:29863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + GTP = ADP + GDP
REACT:R-SSC-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Sus scrofa)
RHEA:10442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + H(+) => D-glucono-1,5-lactone + H2O
REACT:R-CFA-8943007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)
RHEA:34796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => alpha-D-ribose 1,5-bisphosphate + H(+)
REACT:R-GGA-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Gallus gallus)
REACT:R-XTR-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Xenopus tropicalis)
RHEA:42461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzofuran + H(+) + NADH + O2 => biphenyl-2,2',3-triol + NAD(+)
REACT:R-GGA-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Gallus gallus)
REACT:R-BTA-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Bos taurus)
RHEA:68343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phospho-S-sulfopantetheine + H2O <=> (R)-S-sulfopantetheine + phosphate
REACT:R-MMU-1475414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Mus musculus)
REACT:R-CFA-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Canis familiaris)
REACT:R-XTR-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Xenopus tropicalis)
REACT:R-XTR-9627350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) binds XIAP (Xenopus tropicalis)
REACT:R-BTA-8863471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR is bound by DAB2 and ARH (Bos taurus)
REACT:R-RNO-5422942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXRA:PPARD binds FABP5:atRA (Rattus norvegicus)
REACT:R-BTA-9021627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
REACT:R-SSC-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Sus scrofa)
RHEA:52135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O <=> a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)
REACT:R-BTA-5654428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates SHC1 (Bos taurus)
REACT:R-DME-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-CFA-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Canis familiaris)
REACT:R-CFA-198611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates IKKalpha (Canis familiaris)
RHEA:43751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexacosanoate <=> AMP + diphosphate + hexacosanoyl-CoA
RHEA:56541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol => 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA
RHEA:57292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+)
RHEA:15050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-glucose + H2O => D-glucose + GDP + H(+)
RHEA:19711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA
REACT:R-DRE-193073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Danio rerio)
REACT:R-DRE-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Danio rerio)
REACT:R-MMU-6801666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates CENPJ (Mus musculus)
REACT:R-CFA-4608852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 ubiquitinates PRICKLE1 (Canis familiaris)
REACT:R-MMU-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Mus musculus)
RHEA:24902	skos:prefLabel	"cyclic-guanylate-specific phosphodiesterase"
RHEA:24902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclic-guanylate-specific phosphodiesterase"
RHEA:24902	skos:altLabel	"c-di-GMP-specific phosphodiesterase"
RHEA:24902	skos:altLabel	"phosphodiesterase A1"
RHEA:24902	skos:altLabel	"PDEA1"
RHEA:24902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)
REACT:R-PFA-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Plasmodium falciparum)
REACT:R-HSA-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Homo sapiens)
RHEA:18790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine 6-phosphate => D-galactosamine 6-phosphate
RHEA:28013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanoyl-CoA + succinate <=> propanoate + succinyl-CoA
RHEA:10437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O
REACT:R-MMU-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Mus musculus)
REACT:R-DRE-5693551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BRCA1-A complex at multiple sites by ATM (Danio rerio)
REACT:R-PFA-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Plasmodium falciparum)
REACT:R-DME-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Drosophila melanogaster)
RHEA:68448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal
RHEA:12928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]
RHEA:51096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Dictyostelium discoideum)
REACT:R-DRE-5577213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Danio rerio)
RHEA:32127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-proline + O2 = cis-4-hydroxy-L-proline + CO2 + succinate
RHEA:32127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-proline cis-4-hydroxylase"
RHEA:32127	skos:prefLabel	"L-proline cis-4-hydroxylase"
RHEA:53289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-scyllo-inosose + H2O => 5-dehydro-L-gluconate + H(+)
GO:0015346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric triacetylfusarinine C:proton symporter activity
GO:0015346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric triacetylfusarinine C:hydrogen symporter activity
REACT:R-RNO-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Rattus norvegicus)
REACT:R-HSA-6794349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)
REACT:R-DRE-114697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Danio rerio)
REACT:R-SSC-1592349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14 (MT1-MMP) binds TIMP2 (Sus scrofa)
GO:0050315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	synephrine dehydratase activity
GO:0050315	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming)
REACT:R-CFA-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Canis familiaris)
REACT:R-SSC-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Sus scrofa)
RHEA:61212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucoside + UDP
REACT:R-HSA-2586553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 Phosphorylates LEPR (Homo sapiens)
REACT:R-HSA-73932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resynthesis of excised residue by POLB (Homo sapiens)
RHEA:30975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 5 A = 5 AH2 + all-trans-3,4-didehydrolycopene
RHEA:30975	skos:prefLabel	"phytoene desaturase (3,4-didehydrolycopene-forming)"
RHEA:30975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phytoene desaturase (3,4-didehydrolycopene-forming)"
RHEA:30975	skos:altLabel	"5-step phytoene desaturase"
REACT:R-CEL-6786239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
REACT:R-CEL-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Caenorhabditis elegans)
RHEA:12449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate + H2O => (R)-pantoate + beta-alanine
RHEA:51108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-9716258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimethyl fumarate modifies Cys191 in GSDMD (Bos taurus)
RHEA:25443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> delta-selinene + diphosphate
RHEA:59527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] <=> 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]
REACT:R-MMU-6805740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 methylates TP53 (Mus musculus)
RHEA:20964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
REACT:R-HSA-2900743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 HD+PEST domain mutants bind JAG1 (Homo sapiens)
REACT:R-BTA-2395223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyridinoline cross-links (Bos taurus)
REACT:R-CFA-4647593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP400 binds CDKN1A promoter (Canis familiaris)
REACT:R-SSC-1606789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses DS (Sus scrofa)
GO:0043894	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein acetyltransferase activity
GO:0043894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pat enzyme
GO:0043894	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Pat
GO:0043894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA synthetase acetyltransferase activity
REACT:R-DRE-211882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A7 can 6beta-hydroxylate testosterone (Danio rerio)
RHEA:64650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H(+) + NADPH => (E)-coniferaldehyde + CoA + NADP(+)
RHEA:52462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate
RHEA:58703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + NADPH + rifampicin <=> FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal
REACT:R-XTR-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)
REACT:R-GGA-5603467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C is released from PROCR (Gallus gallus)
RHEA:14651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylmacrocin + dTDP + H(+) => demethyllactenocin + dTDP-beta-L-mycarose
REACT:R-HSA-3451153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)
REACT:R-MMU-1296127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of voltage gated Potassium channels (Mus musculus)
RHEA:10591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH <=> 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]
RHEA:38806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine
RHEA:24467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phospho-D-galactonate <=> D-glyceraldehyde 3-phosphate + pyruvate
REACT:R-DDI-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Dictyostelium discoideum)
REACT:R-MMU-375339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Mus musculus)
REACT:R-BTA-8950269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Bos taurus)
REACT:R-HSA-1592398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP8 (Homo sapiens)
REACT:R-MMU-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Mus musculus)
RHEA:23014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid methyl ester + S-adenosyl-L-homocysteine => a fatty acid + S-adenosyl-L-methionine
REACT:R-SSC-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Sus scrofa)
REACT:R-HSA-170131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Homo sapiens)
RHEA:33356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA
REACT:R-DME-1295632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA2A dephosphorylates SPRY2 (Drosophila melanogaster)
REACT:R-SSC-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Sus scrofa)
REACT:R-HSA-5668718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
REACT:R-SSC-372529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of acetylcholine at the synapse (Sus scrofa)
REACT:R-HSA-5490230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFXBO-SG, AFNBO-SG translocate from cytosol to extracellular region (Homo sapiens)
REACT:R-XTR-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Xenopus tropicalis)
RHEA:54130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-BTA-5602295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F22 20-hydroxylates TrXA3 (Bos taurus)
REACT:R-SCE-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Saccharomyces cerevisiae)
REACT:R-CEL-9693478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A agonists (Caenorhabditis elegans)
RHEA:34680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + methylphosphonate => adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate
REACT:R-SPO-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Schizosaccharomyces pombe)
REACT:R-DRE-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Danio rerio)
REACT:R-RNO-2213240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of disulphide bonds in MHC II antigens (Rattus norvegicus)
RHEA:33094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate
RHEA:10195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sulfate(out) <=> ADP + H(+) + phosphate + sulfate(in)
RHEA:66443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-one + NADP(+) <=> but-3-en-2-one + H(+) + NADPH
RHEA:25929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylquinoline + A + H2O => 3-methylquinolin-2(1H)-one + AH2
GO:0052886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ZDS activity
GO:0052886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9'-dicis-carotene:quinone oxidoreductase activity
GO:0052886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	9,9'-di-cis-zeta-carotene desaturase activity
GO:0052886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	zeta-carotene desaturase activity
RHEA:63187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 O2 <=> H(+) + NAD(+) + 2 superoxide
RHEA:16321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-indan-1-ol + NADP(+) = H(+) + indan-1-one + NADPH
REACT:R-DME-6801808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A,REG3G binds bacterial peptidoglycan (Drosophila melanogaster)
REACT:R-SSC-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)
RHEA:28870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + lactose(in) <=> H(+)(out) + lactose(out)
RHEA:50371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-2-ol + H(+) + NADPH + O2 <=> 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)
REACT:R-HSA-8950522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1:p-STAT4 translocates to the nucleus (Homo sapiens)
RHEA:34819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocurcumin + NADP(+) = curcumin + H(+) + NADPH
RHEA:24827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:43344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) = [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate
RHEA:43344	skos:prefLabel	"sulfur carrier protein ThiS adenylyltransferase"
RHEA:43344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfur carrier protein ThiS adenylyltransferase"
REACT:R-RNO-909729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JAK kinases (Rattus norvegicus)
RHEA:36319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADPH + octadecanoyl-CoA = CoA + 2 NADP(+) + octadecan-1-ol
REACT:R-CFA-1475022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)
REACT:R-BTA-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Bos taurus)
REACT:R-DME-77321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Drosophila melanogaster)
RHEA:44224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoate + ATP + CoA = 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate
REACT:R-HSA-508247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
REACT:R-MMU-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Mus musculus)
RHEA:53005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-XTR-114256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS:APAF1 binds procaspase-9 (Xenopus tropicalis)
REACT:R-CEL-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Caenorhabditis elegans)
REACT:R-CFA-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Canis familiaris)
RHEA:62135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + dTTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dTDP
GO:0015147	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity
GO:0015147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinose transmembrane transporter activity
REACT:R-DME-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)
REACT:R-CEL-77304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Caenorhabditis elegans)
REACT:R-CFA-5693593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop extension by DNA polymerases (Canis familiaris)
REACT:R-GGA-914018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Gallus gallus)
RHEA:61344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)
REACT:R-DRE-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Danio rerio)
REACT:R-MMU-192065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)
RHEA:17104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-acyl-(R)-carnitine <=> (R)-carnitine + a fatty acid + H(+)
RHEA:30143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoyl-CoA = CoA + H(+) + octanoate
RHEA:37166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-SSC-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Sus scrofa)
REACT:R-CFA-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Canis familiaris)
REACT:R-MMU-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Mus musculus)
RHEA:71206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoarginine(in) <=> L-homoarginine(out)
REACT:R-HSA-5336413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DT:HBEGF:CD9 is transported from clathrin-coated vesicle to endosome (Homo sapiens)
REACT:R-MMU-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Mus musculus)
RHEA:64848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hex-3-en-1-ol + benzoyl-CoA = (3Z)-hex-3-en-1-yl benzoate + CoA
RHEA:43875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oate + ATP + CoA <=> 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate
RHEA:27562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 3 diphosphate
RHEA:31565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + leukotriene D4 => H2O + leukotriene C4
RHEA:26030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine + O2 <=> 3-aminopropanal + H2O2 + N-acetylputrescine
REACT:R-HSA-9678766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 binds CYP3A4 inhibitors (Homo sapiens)
GO:0008381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanosensitive ion channel activity
GO:0008381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanically gated channel activity
GO:0008381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanically-gated channel activity
GO:0008381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanically-gated ion channel activity
REACT:R-RNO-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Rattus norvegicus)
REACT:R-MMU-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Mus musculus)
RHEA:18113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP
REACT:R-HSA-9022625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds FOXG1 (Homo sapiens)
REACT:R-XTR-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Xenopus tropicalis)
REACT:R-SCE-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Saccharomyces cerevisiae)
REACT:R-GGA-8848335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37 binds  IL18R1 (Gallus gallus)
GO:0099580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion antiporter activity involved in regulation of post-synaptic membrane potential
GO:0099580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion antiporter activity involved in regulation of postsynaptic membrane potential
RHEA:39996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylethanolamine + H2O => a fatty acid + ethanolamine
RHEA:19307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA => 3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA
RHEA:14109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH
REACT:R-CEL-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)
REACT:R-RNO-193702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of the ICD migrates to the nucleus (Rattus norvegicus)
REACT:R-GGA-8937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)
RHEA:45691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) <=> N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)
REACT:R-GGA-8985594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYO9B inactivates RHOA (Gallus gallus)
REACT:R-HSA-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Homo sapiens)
RHEA:12085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + NAD(+) => D-fructose + H(+) + NADH
REACT:R-MMU-1482695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Mus musculus)
REACT:R-BTA-450222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)
GO:0052765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420H2 oxidase activity
GO:0052765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420H2 oxidase activity
GO:0052765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420H2:oxygen oxidoreductase activity
GO:0052765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced coenzyme F420 oxidase activity
REACT:R-DDI-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)
REACT:R-DDI-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Dictyostelium discoideum)
EC:2.7.7.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA-directed DNA polymerase"
EC:2.7.7.7	skos:altLabel	"DNA nucleotidyltransferase (DNA-directed)"
EC:2.7.7.7	skos:altLabel	"DNA-dependent DNA polymerase"
EC:2.7.7.7	skos:prefLabel	"DNA-directed DNA polymerase"
RHEA:52572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + NAD(+) = (2E)-butenoyl-CoA + H(+) + NADH
GO:0004659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenyltransferase activity
REACT:R-BTA-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Bos taurus)
RHEA:43919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:46600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)
RHEA:59318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiono-1,5-lactone + H2O2 => D-cellobiose + O2
REACT:R-DRE-430311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rsu-1 interacts with Pinch1 (Danio rerio)
REACT:R-GGA-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Gallus gallus)
RHEA:63786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine
REACT:R-CEL-888577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GABA by GAD2 (Caenorhabditis elegans)
REACT:R-XTR-388605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMC(138-176) binds MC2R (Xenopus tropicalis)
RHEA:70275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + raffinose = D-galactose + sucrose
REACT:R-MMU-373734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin interacts with Podocin (Mus musculus)
RHEA:47971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 + H2O <=> ganglioside GM3 + N-acetyl-beta-D-galactosamine
REACT:R-DME-209322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	In the absence of ARM, GRO binds to PAN and inhibits transcription (Drosophila melanogaster)
RHEA:60031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> 4-terpineol + diphosphate
REACT:R-CFA-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)
REACT:R-CEL-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Caenorhabditis elegans)
REACT:R-BTA-193961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Bos taurus)
REACT:R-MMU-2197697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)
GO:0102627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	parthenolide 3beta-hydroxylase activity
REACT:R-MMU-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
RHEA:60667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH <=> NADH + phosphate
RHEA:58188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene + dimethylallyl diphosphate + H2O = dihydroisopentenyldehydrorhodopin + diphosphate
REACT:R-GGA-5675948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFRSF6B binds TNFSF6,14,15 (Gallus gallus)
GO:0016767	skos:altLabel	"prephytoene-diphosphate synthase"
GO:0016767	skos:prefLabel	"15-cis-phytoene synthase"
GO:0016767	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity
GO:0016767	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prephytoene-diphosphate synthase activity
GO:0016767	skos:altLabel	"PSase"
GO:0016767	skos:altLabel	"phytoene synthetase"
GO:0016767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate
GO:0016767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"15-cis-phytoene synthase"
GO:0016767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl-diphosphate geranylgeranyltransferase activity
GO:0016767	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytoene synthetase activity
GO:0016767	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PSase activity
GO:0016767	skos:altLabel	"geranylgeranyl-diphosphate geranylgeranyltransferase"
REACT:R-RNO-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Rattus norvegicus)
REACT:R-CEL-8876837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB21 GEFs exchange GTP for GDP on RAB21 (Caenorhabditis elegans)
REACT:R-PFA-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Plasmodium falciparum)
REACT:R-XTR-4722133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Xenopus tropicalis)
REACT:R-CFA-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Canis familiaris)
RHEA:45091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline
REACT:R-XTR-74247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Xenopus tropicalis)
REACT:R-DME-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)
REACT:R-HSA-6797766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the BIRC5 gene (Homo sapiens)
REACT:R-CFA-2730959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN7:OSTM1 exchanges Cl- for H+ (Canis familiaris)
REACT:R-HSA-9021952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBFOX1 gene expression is inhibited by MECP2 (Homo sapiens)
RHEA:17460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein]-L-cysteine + L-cysteine <=> [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine
RHEA:32577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,5R)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate
REACT:R-HSA-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Homo sapiens)
REACT:R-HSA-1433456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs (Homo sapiens)
REACT:R-RNO-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Rattus norvegicus)
RHEA:40891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine
RHEA:39804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH
RHEA:20615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => 3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine
RHEA:41432	skos:altLabel	"3-methyl-L-tyrosine peroxidase"
RHEA:41432	skos:prefLabel	"3-methyl-L-tyrosine peroxygenase"
RHEA:41432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-methyl-L-tyrosine peroxygenase"
RHEA:41432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-L-tyrosine + H2O2 = 5-hydroxy-3-methyl-L-tyrosine + H2O
RHEA:41432	skos:altLabel	"3-methyltyrosine peroxidase"
REACT:R-SSC-5690669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds itself to form homo-oligomers (Sus scrofa)
RHEA:61118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-1549564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPTN11 dephosphorylates SPRY2 (Sus scrofa)
REACT:R-BTA-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Bos taurus)
REACT:R-RNO-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Rattus norvegicus)
REACT:R-HSA-77323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Homo sapiens)
RHEA:35865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA
RHEA:50507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]
RHEA:22631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate <=> (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate
RHEA:47547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline betaine <=> cis-4-hydroxy-D-proline betaine
REACT:R-MMU-6810843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin binds periplakin (Mus musculus)
REACT:R-RNO-198563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO1 dioxygenates L-Trp to NFK (Rattus norvegicus)
REACT:R-RNO-1678981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR9 processing at neutral pH (Rattus norvegicus)
REACT:R-HSA-9723906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective TP53 does not tetramerize (Homo sapiens)
RHEA:58428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH
REACT:R-DRE-5672958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from KSR1:MARK3 (Danio rerio)
REACT:R-GGA-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Gallus gallus)
RHEA:46078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + NAD(+) => (2E)-eicosenoyl-CoA + H(+) + NADH
RHEA:33964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + isopentenyl phosphate => ADP + isopentenyl diphosphate
REACT:R-RNO-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Rattus norvegicus)
REACT:R-HSA-9031521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the APOC2 gene (Homo sapiens)
REACT:R-XTR-1234167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of HIF:CBP:p300 complex at promoters (Xenopus tropicalis)
RHEA:18935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA
REACT:R-HSA-5607726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Homo sapiens)
RHEA:55352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol = 13-cis-retinol
REACT:R-PFA-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Plasmodium falciparum)
REACT:R-HSA-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Homo sapiens)
RHEA:35968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-8964333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Sus scrofa)
RHEA:50728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(4-hydroxyphenyl)acetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O
RHEA:59069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethyldeoxyspectinabilin + S-adenosyl-L-methionine => deoxyspectinabilin + S-adenosyl-L-homocysteine
REACT:R-CFA-2066778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Canis familiaris)
REACT:R-SSC-6806957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET receptor dimerizes (Sus scrofa)
REACT:R-DME-390011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPO dimer binds to SAV (Drosophila melanogaster)
REACT:R-RNO-1471314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNP1-3 bind CD4 (Rattus norvegicus)
RHEA:49178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine
REACT:R-CEL-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Caenorhabditis elegans)
REACT:R-SSC-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Sus scrofa)
RHEA:19394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + pyruvate => (S)-2-amino-6-oxohexanoate + L-alanine
RHEA:16045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP
RHEA:58366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty aldehyde + H(+) + NADPH => a medium-chain primary fatty alcohol + NADP(+)
REACT:R-CFA-2243926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of histidino-hydroxylysinonorleucine cross-links (Canis familiaris)
REACT:R-BTA-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Bos taurus)
RHEA:45569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparosan](n) => [acharan](n)
RHEA:25375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA
REACT:R-DRE-1676164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)
REACT:R-XTR-5653770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)
RHEA:26184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate
REACT:R-MMU-8937989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRC1 complexes (Mus musculus)
REACT:R-RNO-1655879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiosulfate can transfer its sulfur atom to glutathione (Rattus norvegicus)
RHEA:41309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O
GO:0010013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-1-naphthylphthalamic acid binding
RHEA:53863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) <=> dehydrocholate + H(+) + NADPH
REACT:R-BTA-202721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 binds JAM3 (Bos taurus)
REACT:R-CFA-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Canis familiaris)
RHEA:50308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate <=> AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]
RHEA:42370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CEL-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Caenorhabditis elegans)
RHEA:68707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) <=> 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-XTR-2029272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of PLCG from FCGR (Xenopus tropicalis)
REACT:R-XTR-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Xenopus tropicalis)
RHEA:11187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(carbamoylamino)propanoate + 2 H(+) + H2O <=> beta-alanine + CO2 + NH4(+)
REACT:R-CFA-418858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoGTPase GEF's recruited to DCC (Canis familiaris)
REACT:R-DME-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Drosophila melanogaster)
REACT:R-CFA-193072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
REACT:R-DME-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Drosophila melanogaster)
RHEA:10391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + oxaloacetate <=> CO2 + GDP + phosphoenolpyruvate
REACT:R-SPO-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Schizosaccharomyces pombe)
REACT:R-BTA-72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of mRNA at the 3'-end (Bos taurus)
REACT:R-GGA-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)
RHEA:72111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) = L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)
REACT:R-MMU-5218643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90AA1 binds p-6Y-VEGFR2 (Mus musculus)
RHEA:29526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)
REACT:R-MMU-417896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y6 receptor can bind to UDP (Mus musculus)
RHEA:37053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate
REACT:R-RNO-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Rattus norvegicus)
RHEA:42385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4'-diaponeurosporenal + H2O + NAD(+) => 4,4'-diaponeurosporenoate + 2 H(+) + NADH
REACT:R-RNO-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Rattus norvegicus)
REACT:R-RNO-191790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading and methylation of Sm proteins onto SMN Complexes (Rattus norvegicus)
RHEA:56262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose
RHEA:15635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+) => 3,4-dihydroxyphenylacetate + O2
REACT:R-DRE-450466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1:mRNA complex is destroyed (Danio rerio)
RHEA:61334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + indoxyl sulfate(out) + phosphate => ATP + H2O + indoxyl sulfate(in)
RHEA:23119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + CoA <=> 4-hydroxybenzoyl-CoA + AMP + diphosphate
RHEA:37254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteamine S-phosphate + H2O <=> cysteamine + phosphate
REACT:R-CFA-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Canis familiaris)
REACT:R-DDI-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
REACT:R-GGA-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Gallus gallus)
REACT:R-HSA-9604451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH4 binds FLT4 gene promoter (Homo sapiens)
RHEA:58314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-substituted-cholesterol + D-glucose => 25-substituted-cholesteryl beta-D-glucoside + H2O
RHEA:48343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + ATP + CoA <=> a medium-chain fatty acyl-CoA + AMP + diphosphate
GO:0047750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestenol delta-isomerase activity
GO:0047750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestenol D-isomerase activity
GO:0047750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta7-cholestenol delta7-delta8-isomerase activity
REACT:R-SSC-3322014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-a (Sus scrofa)
RHEA:22345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA => (R)-rosmarinate + CoA
REACT:R-CFA-2507854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Canis familiaris)
RHEA:34458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene <=> 9-cis-beta-carotene
REACT:R-BTA-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Bos taurus)
GO:0031771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 orexin receptor binding
GO:0031771	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 hypocretin receptor ligand
GO:0031771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 hypocretin receptor binding
GO:0031771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OX1 orexin receptor binding
REACT:R-CFA-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Canis familiaris)
REACT:R-XTR-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Xenopus tropicalis)
RHEA:58981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citral + H2O + O2 => 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2
REACT:R-DME-9610154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated MAP2Ks and MAPKs (Drosophila melanogaster)
REACT:R-MMU-5618073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Mus musculus)
RHEA:18955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + sepiapterin => L-erythro-7,8-dihydrobiopterin + NADP(+)
REACT:R-SSC-8856223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Sus scrofa)
REACT:R-GGA-5696197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Gallus gallus)
GO:0018686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy pseudo-oxynicotine monooxygenase activity
REACT:R-MMU-5676589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANKL,sRANKL trimer binds RANK (Mus musculus)
RHEA:65052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trifluoromethyl)benzyl alcohol + NAD(+) = 4-(trifluoromethyl)benzaldehyde + H(+) + NADH
RHEA:22110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + NH4(+) => L-threonine
REACT:R-DME-2168079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL (GWL) phosphorylates ARPP19 (Drosophila melanogaster)
REACT:R-HSA-5687101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 phosphorylates FOXO3 (Homo sapiens)
REACT:R-CEL-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Caenorhabditis elegans)
REACT:R-DME-451856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FT is phosphorylated by DCO (Drosophila melanogaster)
RHEA:57382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-9693978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Small molecule inhibitor binds RIPK1, RIPK3 (Homo sapiens)
RHEA:67488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + glycine = CoA + glycocholate + H(+)
GO:0047963	skos:altLabel	"cholyl-CoA glycine-taurine N-acyltransferase"
GO:0047963	skos:altLabel	"amino acid N-choloyltransferase"
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholyl-CoA:taurine N-acyltransferase activity
GO:0047963	skos:altLabel	"glycine--taurine N-acyltransferase"
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amino acid N-choloyltransferase activity
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bile acid-CoA:amino acid N-acyltransferase activity
GO:0047963	skos:altLabel	"BACAT"
GO:0047963	skos:altLabel	"glycine N-choloyltransferase"
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BACAT activity
GO:0047963	skos:altLabel	"BAT"
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bile acid-CoA:amino acid N-acyltransferase"
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine N-choloyltransferase activity
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine--taurine N-acyltransferase activity
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BAT activity
GO:0047963	skos:prefLabel	"bile acid-CoA:amino acid N-acyltransferase"
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choloyl-CoA:glycine N-choloyltransferase activity
GO:0047963	skos:altLabel	"cholyl-CoA:taurine N-acyltransferase"
GO:0047963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholyl-CoA glycine-taurine N-acyltransferase activity
REACT:R-DRE-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Danio rerio)
REACT:R-DDI-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Dictyostelium discoideum)
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin-linked NAD reductase activity
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH flavodoxin oxidoreductase activity
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2-ferredoxin oxidoreductase activity
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, reduced nicotinamide adenine dinucleotide-ferredoxin
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin-nicotinamide adenine dinucleotide reductase activity
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferredoxin-NAD reductase activity
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferredoxin-NAD+ reductase activity
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-ferredoxinTOL reductase (component of toluene dioxygenase)
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-ferredoxin reductase activity
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferredoxin:NAD+ oxidoreductase activity
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-ferredoxin oxidoreductase activity
GO:0008860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-ferredoxin reductase activity
RHEA:13865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chitobiosyldiphosphodolichol beta-mannosyltransferase"
RHEA:13865	skos:altLabel	"guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase"
RHEA:13865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol = beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)
RHEA:13865	skos:prefLabel	"chitobiosyldiphosphodolichol beta-mannosyltransferase"
RHEA:13865	skos:altLabel	"GDP-mannose-dolichol diphosphochitobiose mannosyltransferase"
REACT:R-SSC-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Sus scrofa)
REACT:R-DRE-427645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A3 cotransports Pi, 2Na+ (Danio rerio)
REACT:R-SSC-212710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR activates PLC-gamma1 by phosphorylation (Sus scrofa)
GO:0033926	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-alpha-N-acetylgalactosaminidase activity
GO:0033926	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity
GO:0033926	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-alpha-acetylgalactosaminidase activity
GO:0033926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycopeptide alpha-N-acetylgalactosaminidase activity
REACT:R-DDI-9759206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Dictyostelium discoideum)
REACT:R-RNO-9681294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6R binds IL6R inhibitors (Rattus norvegicus)
REACT:R-DRE-8848939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds KHDRBS1 (Danio rerio)
REACT:R-GGA-1604712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP7 by trypsin (Gallus gallus)
REACT:R-DRE-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Danio rerio)
RHEA:13899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prephenate => chorismate
RHEA:70564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-GGA-8851919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 and GRB2 (Gallus gallus)
REACT:R-XTR-1470009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs (Xenopus tropicalis)
EC:3.4.14.5	skos:altLabel	"post-proline dipeptidyl aminopeptidase IV"
EC:3.4.14.5	skos:prefLabel	"dipeptidyl-peptidase IV"
EC:3.4.14.5	skos:altLabel	"dipeptidyl aminopeptidase IV"
EC:3.4.14.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dipeptidyl-peptidase IV"
EC:3.4.14.5	skos:altLabel	"Xaa-Pro-dipeptidylaminopeptidase"
EC:3.4.14.5	skos:altLabel	"Gly-Pro naphthylamidase"
EC:3.4.14.5	skos:altLabel	"DPP IV"
GO:0016413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyltransferase activity
REACT:R-HSA-9603791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX16:PEX19:PEX3 dissociates (Homo sapiens)
RHEA:36931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0050082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltose:phosphate 1-beta-D-glucosyltransferase activity
GO:0050082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose phosphorylase activity
GO:0000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphite transporter activity
GO:0000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite transmembrane transporter activity
REACT:R-XTR-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Xenopus tropicalis)
REACT:R-RNO-6782106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates SNX3, CFTR (Rattus norvegicus)
GO:0016620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
REACT:R-CEL-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)
RHEA:61425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-cis-nepetalactol + NAD(+) => cis-cis-nepetalactone + H(+) + NADH
GO:0036434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitronate monooxygenase (FMN-linked) activity
RHEA:19600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine <=> L-citrulline + NH4(+)
REACT:R-MMU-1604741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP14 (MT1-MMP) (Mus musculus)
REACT:R-DME-209765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Drosophila melanogaster)
REACT:R-DME-8956659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates YAP1 (Drosophila melanogaster)
RHEA:68229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + Na(+)(in) => glycine(out) + Na(+)(out)
RHEA:36369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + H(+) => (S)-alpha-hydroxyglutarate-gamma-lactone + H2O
REACT:R-XTR-388900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurotensin receptors can bind neurotensins (Xenopus tropicalis)
REACT:R-RNO-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)
RHEA:10744	skos:prefLabel	"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase"
RHEA:10744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase"
RHEA:10744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO2 + NADH
RHEA:10744	skos:altLabel	"DCD dehydrogenase"
RHEA:10744	skos:altLabel	"dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase"
RHEA:10744	skos:altLabel	"(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase"
GO:0008157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphatase 1 binding
REACT:R-DME-350477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex (Drosophila melanogaster)
RHEA:57795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dinitrotoluene + NADH + O2 <=> 4-methyl-6-nitrocatechol + NAD(+) + nitrite
REACT:R-RNO-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Rattus norvegicus)
RHEA:48691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine <=> D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl
GO:0038131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NRG2 receptor activity
GO:0038131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NRG1 receptor activity
GO:0038131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRG receptor activity
GO:0038131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuregulin receptor activity
RHEA:38343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + H2O = (20S)-ginsenoside Rg3 + D-glucose
REACT:R-GGA-8950181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y693-STAT4 dimer translocates to the nucleus (Gallus gallus)
REACT:R-CEL-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Caenorhabditis elegans)
REACT:R-DRE-390835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD1,5 bind DA (Danio rerio)
RHEA:64102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + TAN-1612 => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine
REACT:R-MMU-390224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Mus musculus)
REACT:R-HSA-1458485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RALA hydrolyzes GTP (Homo sapiens)
REACT:R-HSA-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)
RHEA:41796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine
REACT:R-HSA-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Homo sapiens)
EC:1.99.-.-	skos:prefLabel	"Other enzymes using O2 as oxidant"
EC:1.99.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other enzymes using O2 as oxidant"
GO:0008955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidoglycan transglycosylase activity
GO:0008955	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	penicillin binding protein (3 or 1B) activity
GO:0008955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidoglycan glycosyltransferase"
GO:0008955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity
GO:0008955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan glycosyltransferase activity
GO:0008955	skos:prefLabel	"peptidoglycan glycosyltransferase"
GO:0008955	skos:altLabel	"bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase"
GO:0008955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PG-II activity
GO:0008955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidoglycan TGase activity
GO:0008955	skos:altLabel	"peptidoglycan transglycosylase"
GO:0008955	skos:altLabel	"penicillin binding protein (3 or 1B)"
GO:0008955	skos:altLabel	"peptidoglycan TGase"
GO:0008955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity
GO:0008955	skos:altLabel	"PG-II"
GO:0008955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)
GO:0015553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthosine transmembrane transporter activity
REACT:R-MMU-8944219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVI (Mus musculus)
RHEA:72324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + thiosulfate(out) => 3 Na(+)(in) + thiosulfate(in)
GO:0016361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I activin receptor activity
GO:0016361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activin receptor activity, type I
REACT:R-HSA-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Homo sapiens)
REACT:R-CEL-2327746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 aggregation (Caenorhabditis elegans)
REACT:R-DRE-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Danio rerio)
RHEA:43104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + an N-acyleicosasphinganine + O2 = A + an N-acyleicosasphing-4-enine + 2 H2O
RHEA:48081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] => ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-173597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)
REACT:R-HSA-2029271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-DDI-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Dictyostelium discoideum)
REACT:R-SPO-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Schizosaccharomyces pombe)
RHEA:11648	skos:prefLabel	"(-)-menthol monooxygenase"
RHEA:11648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-menthol monooxygenase"
RHEA:11648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol + H(+) + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP(+)
REACT:R-DRE-73646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Danio rerio)
RHEA:58933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH => 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)
REACT:R-BTA-2404135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4 binds atROL (Bos taurus)
GO:0019001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanyl nucleotide binding
GO:0019001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eEF1A complexes with GTP (Homo sapiens)
REACT:R-CFA-5195402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LPIN (Canis familiaris)
RHEA:21350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2 => 8 H(+) + 10 malonyl-CoA
REACT:R-BTA-4719447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO1 (Bos taurus)
REACT:R-CFA-9756169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)
REACT:R-DRE-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Danio rerio)
RHEA:66768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H(+) + phosphate
RHEA:22756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-alcohol oxidase"
RHEA:22756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2
RHEA:22756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecan-1-ol + O2 = dodecanal + H2O2
RHEA:22756	skos:prefLabel	"long-chain-alcohol oxidase"
RHEA:12309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H2O + NAD(+) => 2 H(+) + L-2-aminoadipate + NADH
RHEA:22868	skos:prefLabel	"S-carboxymethylcysteine synthase"
RHEA:22868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-carboxymethylcysteine synthase"
RHEA:22868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-L-alanine + thioglycolate = chloride + H(+) + S-carboxymethyl-L-cysteine
RHEA:49124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + protodeoxyviolaceinate = H2O + NADP(+) + protoviolaceinate
RHEA:21389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminohexano-6-lactam => L-lysine
REACT:R-XTR-416546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Xenopus tropicalis)
REACT:R-XTR-174456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments of the C-strand (Xenopus tropicalis)
REACT:R-DRE-9014295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GAPs stimulate RAC2 GTPase activity (Danio rerio)
RHEA:45701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + H(+) + NADH + O2 => formaldehyde + H2O + N,N-dimethylglycine + NAD(+)
REACT:R-BTA-9008271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Bos taurus)
REACT:R-HSA-4088264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Homo sapiens)
RHEA:50975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
RHEA:32122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-valienol + validamine 7-phosphate <=> GDP + H(+) + validoxylamine A 7'-phosphate
REACT:R-BTA-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Bos taurus)
RHEA:31839	skos:altLabel	"TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase"
RHEA:31839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming)"
RHEA:31839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose
RHEA:31839	skos:prefLabel	"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming)"
RHEA:31839	skos:altLabel	"dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase"
RHEA:37685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA
REACT:R-HSA-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Homo sapiens)
REACT:R-DRE-3322422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits SMARCA4 (Danio rerio)
RHEA:67483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + prekainate <=> CO2 + H2O + kainate + succinate
REACT:R-XTR-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Xenopus tropicalis)
GO:0047319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate--phenylpyruvate transaminase"
GO:0047319	skos:prefLabel	"aspartate--phenylpyruvate transaminase"
GO:0047319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate:phenylpyruvate aminotransferase activity
GO:0047319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate
GO:0047319	skos:altLabel	"aspartate--phenylpyruvate aminotransferase"
GO:0047319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate--phenylpyruvate aminotransferase activity
GO:0047319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-phenylpyruvate transaminase activity
GO:0047319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-phenylpyruvate aminotransferase activity
REACT:R-SSC-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Sus scrofa)
REACT:R-HSA-549424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CCRN4L (NOCTURNIN) (Homo sapiens)
REACT:R-RNO-176175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Stalling of DNA replication fork and RPA binding (Rattus norvegicus)
REACT:R-XTR-1655851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2P hydrolyzes SREBP1A,1C,2 (Xenopus tropicalis)
REACT:R-RNO-1614362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Rattus norvegicus)
REACT:R-BTA-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Bos taurus)
REACT:R-GGA-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Gallus gallus)
REACT:R-SSC-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Sus scrofa)
RHEA:61541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:70127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Homo sapiens)
REACT:R-SSC-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Sus scrofa)
REACT:R-DRE-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Danio rerio)
RHEA:62129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + dGTP => a 2'-deoxyribonucleoside 5'-diphosphate + dGDP
RHEA:22613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA => acetyl-CoA + pyruvate
REACT:R-SPO-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Schizosaccharomyces pombe)
REACT:R-XTR-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Xenopus tropicalis)
RHEA:10012	skos:altLabel	"D-6-hydroxynicotine oxidase"
RHEA:10012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-6-hydroxynicotine oxidase"
RHEA:10012	skos:altLabel	"6-hydroxy-D-nicotine oxidase"
RHEA:10012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2
RHEA:10012	skos:prefLabel	"(R)-6-hydroxynicotine oxidase"
REACT:R-HSA-936963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization (Homo sapiens)
RHEA:53877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in tRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate
RHEA:36002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:35915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-HSA-418918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The UDP/CysLT (P2Y17) receptor can bind UTP (Homo sapiens)
RHEA:66817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + tetrahydroxoborate(in) => 2 Na(+)(out) + tetrahydroxoborate(out)
RHEA:25990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-MMU-9014293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GDIs block activation of RAC2 (Mus musculus)
RHEA:43245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate
RHEA:56503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3,5-bisphosphomevalonate + H(+) <=> CO2 + isopentenyl phosphate + phosphate
RHEA:15520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2),6-disulfo-D-glucosamine <=> H(+) + N-sulfo-D-glucosamine + sulfate
REACT:R-SCE-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Saccharomyces cerevisiae)
RHEA:29448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate(in) => glycolate(out)
REACT:R-HSA-9613490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the nascent HIV-1 transcript: Second Transition (Homo sapiens)
REACT:R-GGA-426522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nonendonucleolytic RISC binds exactly matching target RNAs (Gallus gallus)
REACT:R-GGA-373342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3CR1 binds CX3CL1 (Gallus gallus)
REACT:R-HSA-9731613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)
REACT:R-SCE-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Saccharomyces cerevisiae)
RHEA:60900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in RNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine
RHEA:36414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + hnu <=> calciol
RHEA:72750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene E4(out) <=> leukotriene E4(in)
REACT:R-HSA-427394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of intergenic spacer RNA to yield fragments of 150-300 nucleotides (Homo sapiens)
REACT:R-CFA-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Canis familiaris)
REACT:R-BTA-169895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk's SH3 domain engages C3G (Bos taurus)
REACT:R-MMU-140851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Mus musculus)
REACT:R-BTA-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Bos taurus)
REACT:R-RNO-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Rattus norvegicus)
REACT:R-SSC-74948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates p-RHO to RHO (Sus scrofa)
REACT:R-DME-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Drosophila melanogaster)
RHEA:11548	skos:prefLabel	"acetoxybutynylbithiophene deacetylase"
RHEA:11548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetoxybutynylbithiophene deacetylase"
RHEA:11548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)
RHEA:34578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone
REACT:R-HSA-1989750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FATP1 (SLC27A1) (Homo sapiens)
REACT:R-HSA-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Homo sapiens)
REACT:R-CFA-5362448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh C-terminal fragments are degraded by the proteasome (Canis familiaris)
REACT:R-DDI-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Dictyostelium discoideum)
RHEA:31892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH
RHEA:36268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + theobromine
REACT:R-HSA-983696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Immunoglobulin of the BCR binds antigen (Homo sapiens)
REACT:R-RNO-6800380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAP-1 (Rattus norvegicus)
REACT:R-RNO-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Rattus norvegicus)
REACT:R-HSA-190877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of connexons into the plasma membrane resulting in the formation of hemi-channels (Homo sapiens)
REACT:R-MMU-5625738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Mus musculus)
RHEA:50599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[histone H4] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]
REACT:R-MMU-5686304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Mus musculus)
REACT:R-BTA-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Bos taurus)
RHEA:13640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methane + NADH + O2 <=> H2O + methanol + NAD(+)
RHEA:41763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) <=> CMP + ganglioside GD3 (d18:1(4E)) + H(+)
REACT:R-CFA-9731924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds EDNs (Canis familiaris)
REACT:R-MMU-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Mus musculus)
REACT:R-XTR-6786245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNS1 transforms ATP, L-His, b-Ala to CARN (Xenopus tropicalis)
REACT:R-DRE-209859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decarboxylation of 5-hydroxytryptophan forms serotonin (Danio rerio)
REACT:R-SSC-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Sus scrofa)
RHEA:25863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O <=> 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)
GO:0034930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxypyrene sulfotransferase activity
RHEA:70433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + Li(+)(out) => 2 H(+)(out) + Li(+)(in)
RHEA:61752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolbioside + UDP-alpha-D-glucose = H(+) + rebaudioside B + UDP
REACT:R-DRE-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Danio rerio)
RHEA:40300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:28801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-proline => H2O + L-prolinylglycine
REACT:R-SSC-8984014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Sus scrofa)
REACT:R-SCE-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Saccharomyces cerevisiae)
RHEA:47831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b + H2O <=> ganglioside GD1b + N-acetylneuraminate
REACT:R-HSA-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Homo sapiens)
REACT:R-GGA-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)
RHEA:35896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-BTA-201685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin is released from the destruction complex (Bos taurus)
RHEA:15119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine => 3'-dephospho-CoA + ATP
RHEA:65253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 6-hydroxymellein => diphosphate + verruculide C
RHEA:65452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + hexanoyl-CoA = CoA + ethyl hexanoate
REACT:R-MMU-446894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binding leads to IRAK1:TRAF6 release (Mus musculus)
RHEA:68541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate
REACT:R-GGA-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Gallus gallus)
REACT:R-CEL-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Caenorhabditis elegans)
GO:0052612	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-ring carotenoid 3-hydroxylase activity
GO:0052612	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carotene beta-ring hydroxylase activity
GO:0052612	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-carotene hydroxylase activity
GO:0052612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adonirubin 3-hydroxylase activity
REACT:R-CEL-374663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Ezrin (Caenorhabditis elegans)
REACT:R-HSA-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Homo sapiens)
REACT:R-XTR-5610737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH bind and ubiquitnate GLI1 (Xenopus tropicalis)
REACT:R-HSA-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Homo sapiens)
REACT:R-DME-881988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRY is phosphorylated by SGG (Drosophila melanogaster)
RHEA:66571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O <=> preluffariellolide A
RHEA:37369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
REACT:R-HSA-9656250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective OGG1 mutants do not excise 8-oxoguanine (Homo sapiens)
REACT:R-DME-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Drosophila melanogaster)
RHEA:57607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:16980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + coenzyme M + NADP(+) <=> 2-oxopropyl-coenzyme M + CO2 + NADPH
RHEA:38735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol
REACT:R-CEL-429786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Caenorhabditis elegans)
GO:1990887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity
REACT:R-CFA-6810234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Canis familiaris)
RHEA:69402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)2-lipid A + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA
RHEA:63003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienamide + H2O <=> (11Z,14Z,17Z)-eicosatrienoate + NH4(+)
REACT:R-SSC-8867240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPCAM binds itself to form homotypic cell adhesion (Sus scrofa)
RHEA:57405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + narcotine hemiacetal => H(+) + NADH + noscapine
RHEA:68397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a percarboxylic acid + H2O => a carboxylate + H(+) + H2O2
REACT:R-RNO-8942101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 monoubiquitinates Histone H2B (Rattus norvegicus)
GO:0030351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
GO:0030351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Homo sapiens)
REACT:R-SCE-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Saccharomyces cerevisiae)
REACT:R-HSA-5685605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF7 binds SLAMF7 (Homo sapiens)
REACT:R-CFA-6805640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates KAT6A (Canis familiaris)
REACT:R-GGA-419001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Gallus gallus)
RHEA:67377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-histidine + H2O => glycine + L-histidine
RHEA:13587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + butanoyl phosphate => ATP + butanoate
RHEA:72425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + AMP + H(+) => (E)-4-coumaroyl-AMP + CoA
RHEA:44256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-BTA-8875490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind ubiquitinated MET (Bos taurus)
RHEA:40035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylaspartylglutamate synthase"
RHEA:40035	skos:altLabel	"N-acetylaspartylglutamate synthetase"
RHEA:40035	skos:altLabel	"NAAG synthetase"
RHEA:40035	skos:prefLabel	"N-acetylaspartylglutamate synthase"
RHEA:40035	skos:altLabel	"NAAGS"
RHEA:40035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + N-acetyl-L-aspartate = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate
GO:0004964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LH receptor
GO:0004964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lutropin-choriogonadotropic hormone receptor
GO:0004964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHR
GO:0004964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteinizing hormone receptor activity
GO:0004964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutropin receptor
RHEA:38036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate => (4Z)-2-oxohept-4-enedioate
REACT:R-BTA-936564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 inhibits MAVS-DDX58 interaction. (Bos taurus)
REACT:R-RNO-140872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Rattus norvegicus)
REACT:R-DDI-5693533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C (ARTEMIS) processes DNA DSB ends (Dictyostelium discoideum)
REACT:R-DRE-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Danio rerio)
REACT:R-DRE-5689630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BAP1-interacting complex (Danio rerio)
REACT:R-RNO-381537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Rattus norvegicus)
REACT:R-RNO-8849094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RASA1 (Rattus norvegicus)
RHEA:37486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine <=> 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-3965447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein subunits dissociate from WNT:FZD complex (Canis familiaris)
RHEA:21898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate => (R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP
REACT:R-RNO-5205822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-18 (H3R17) of histone H3 (Rattus norvegicus)
REACT:R-XTR-3249390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Xenopus tropicalis)
RHEA:50482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein]
REACT:R-CFA-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
EC:2.1.1.295	skos:prefLabel	"2-methyl-6-phytyl-1,4-hydroquinone methyltransferase"
EC:2.1.1.295	skos:altLabel	"2-methyl-6-solanyl-1,4-hydroquinone methyltransferase"
EC:2.1.1.295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methyl-6-phytyl-1,4-hydroquinone methyltransferase"
EC:2.1.1.295	skos:altLabel	"MPBQ/MSBQ methyltransferase"
REACT:R-RNO-9024993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Rattus norvegicus)
GO:0102061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-beta-bergamontene synthase activity
GO:0102061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene
GO:0102061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)
GO:0102061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-beta-bergamotene synthase activity
RHEA:24304	skos:altLabel	"glycine cleavage system P-protein"
RHEA:24304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine dehydrogenase (aminomethyl-transferring)"
RHEA:24304	skos:prefLabel	"glycine dehydrogenase (aminomethyl-transferring)"
RHEA:24304	skos:altLabel	"glycine decarboxylase"
RHEA:24304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2
RHEA:24304	skos:altLabel	"glycine-cleavage complex P-protein"
RHEA:24304	skos:altLabel	"glycine dehydrogenase (decarboxylating)"
GO:0010859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent cysteine-type endopeptidase inhibitor activity
REACT:R-DME-77283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Drosophila melanogaster)
RHEA:10366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+) => 2-oxoglutarate + dodecanoyl-CoA + H2O
RHEA:14210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-galactose
REACT:R-RNO-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Rattus norvegicus)
REACT:R-RNO-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Rattus norvegicus)
REACT:R-RNO-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Rattus norvegicus)
REACT:R-HSA-2162188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDMQ10H2 is methylated to DMQ10H2 by COQ5 (Homo sapiens)
EC:3.1.1.104	skos:prefLabel	"5-phospho-D-xylono-1,4-lactonase"
EC:3.1.1.104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-phospho-D-xylono-1,4-lactonase"
REACT:R-HSA-373071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR7 binds CCL19 and 21 ligands (Homo sapiens)
REACT:R-DME-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Drosophila melanogaster)
RHEA:36279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NAD(+)
REACT:R-BTA-210277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-1 (Bos taurus)
REACT:R-CEL-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)
RHEA:15301	skos:altLabel	"D-apiitol reductase"
RHEA:15301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apiitol + NAD(+) = aldehydo-D-apiose + H(+) + NADH
RHEA:15301	skos:prefLabel	"apiose 1-reductase"
RHEA:15301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"apiose 1-reductase"
RHEA:15301	skos:altLabel	"D-apiose reductase"
REACT:R-RNO-9018863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Rattus norvegicus)
RHEA:34150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-L-scyllo-inosose + L-glutamine <=> 2-deoxy-scyllo-inosamine + 2-oxoglutaramate
RHEA:51070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate
REACT:R-DDI-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)
REACT:R-DME-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Drosophila melanogaster)
REACT:R-HSA-8986937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 is phosphorylated at T308 (Homo sapiens)
RHEA:29875	skos:prefLabel	"glycerophosphodiester phosphodiesterase"
RHEA:29875	skos:altLabel	"glycerophosphoryl diester phosphodiesterase"
RHEA:29875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerophosphodiester phosphodiesterase"
RHEA:29875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-L-serine = H(+) + L-serine + sn-glycerol 3-phosphate
REACT:R-SSC-5693356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEMIP hydrolyses HA (Sus scrofa)
REACT:R-HSA-9604664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 (Homo sapiens)
REACT:R-RNO-8854182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D17 binds OPTN:RAB8A (Rattus norvegicus)
EC:2.1.1.192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (adenine(2503)-C(2))-methyltransferase"
EC:2.1.1.192	skos:prefLabel	"23S rRNA (adenine(2503)-C(2))-methyltransferase"
REACT:R-DME-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Drosophila melanogaster)
REACT:R-HSA-5358519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)
RHEA:23722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + propanoyl-CoA
REACT:R-RNO-2467811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of sister chromatids (Rattus norvegicus)
RHEA:37880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl aklanonate => aklaviketone
RHEA:34329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrophenol + H(+) + NADPH + O2
RHEA:33278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)
GO:0008173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA Cap hypermethylation (Homo sapiens)
GO:0008173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA methyltransferase activity
RHEA:67140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 = H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]
GO:0086086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization
GO:0086086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential
GO:0086086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in AV node cell action potential repolarization
REACT:R-DME-5615637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Drosophila melanogaster)
RHEA:18240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxybenzoate + O2 <=> 3-maleylpyruvate + H(+)
REACT:R-RNO-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Rattus norvegicus)
GO:0046789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	host cell surface receptor binding
GO:0046789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cell surface receptor ligand
GO:0046789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cell surface antigen activity, host-interacting
RHEA:29870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ITP <=> ADP + IDP
RHEA:12569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + H(+) + NADH + O2 => 4-nitrocatechol + H2O + NAD(+)
RHEA:68434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal => lutein + O2
REACT:R-XTR-69144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 (Xenopus tropicalis)
RHEA:63345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-amino acyl-L-threonyl-[protein] => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate
RHEA:33161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-XTR-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Xenopus tropicalis)
REACT:R-DRE-211950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 24-hydroxylates CTL (Danio rerio)
REACT:R-DRE-201648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, Endofin, recruits R-Smad1/5/8 (Danio rerio)
RHEA:55754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-2466238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BGN binds Collagen types II, III (Homo sapiens)
RHEA:66630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2 => (2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2
REACT:R-RNO-432110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)
REACT:R-XTR-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Xenopus tropicalis)
REACT:R-BTA-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Bos taurus)
RHEA:38851	skos:prefLabel	"tetracenomycin F2 cyclase"
RHEA:38851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetracenomycin F2 cyclase"
RHEA:38851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + tetracenomycin F2 = H2O + tetracenomycin F1
REACT:R-HSA-4570499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)
REACT:R-XTR-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Xenopus tropicalis)
RHEA:66377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + H2O => D-erythrose + phosphate
REACT:R-HSA-77592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
REACT:R-XTR-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Xenopus tropicalis)
RHEA:56748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Bos taurus)
RHEA:49157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Mus musculus)
RHEA:17592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2'-iminodipropanoate + H2O + NAD(+) <=> H(+) + L-alanine + NADH + pyruvate
REACT:R-XTR-110356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MPG glycosylase by APEX1 at the AP site (Xenopus tropicalis)
REACT:R-XTR-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Xenopus tropicalis)
REACT:R-GGA-917888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF binds 2Fe3+ to form holoTF (Gallus gallus)
RHEA:37286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-histidine <=> L-alanine + L-histidine
RHEA:19587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5beta-cholan-24-oate + H(+) + NADH => lithocholate + NAD(+)
REACT:R-MMU-112379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of elongation factors to form elongation complex (Mus musculus)
RHEA:62559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + H(+) <=> 4-methylcatechol + CO2
REACT:R-SSC-191062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of Klotho-bound FGFR1c (Sus scrofa)
REACT:R-MMU-3791149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Mus musculus)
REACT:R-PFA-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Plasmodium falciparum)
REACT:R-MMU-6803063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial LPS, PGN (Mus musculus)
REACT:R-HSA-5687121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPKAPK5 phosphorylates HSPB1 (Homo sapiens)
REACT:R-BTA-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Bos taurus)
REACT:R-CFA-9707516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM dissociates from MetHb (Canis familiaris)
REACT:R-XTR-912757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S585-IL3RB binds 14-3-3 proteins (Xenopus tropicalis)
RHEA:22743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-hexose <=> ADP + D-hexose 6-phosphate + H(+)
REACT:R-DRE-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Danio rerio)
RHEA:62716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stemphyloxin I = stemphyloxin II
RHEA:55922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3) => [cis-1,4-isoprene](n) + O2
REACT:R-SSC-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Sus scrofa)
RHEA:44083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + undecanoate <=> AMP + diphosphate + undecanoyl-CoA
REACT:R-MMU-2730861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Mus musculus)
REACT:R-SSC-9701000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1:BARD1 heterodimer autoubiquitinates (Sus scrofa)
REACT:R-DRE-422051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the signal peptide of Preproghrelin (Danio rerio)
REACT:R-SSC-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Sus scrofa)
RHEA:35163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + minocycline(in) = H(+)(in) + minocycline(out)
RHEA:10052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoate + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH
RHEA:10052	skos:altLabel	"(R)-2-hydroxyisocaproate dehydrogenase"
RHEA:10052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH
RHEA:10052	skos:prefLabel	"D-2-hydroxyacid dehydrogenase (NAD(+))"
RHEA:10052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-2-hydroxyacid dehydrogenase (NAD(+))"
RHEA:10052	skos:altLabel	"D-2-hydroxyisocaproate dehydrogenase"
RHEA:44127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + tetradecan-1-ol <=> CoA + tetradecanyl hexadecanoate
RHEA:47045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnitine + acetyl-CoA => acetoacetate + N,N,N-trimethylglycyl-CoA
REACT:R-GGA-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Gallus gallus)
RHEA:35798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin A + UDP
RHEA:34738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + sphinganine <=> an N-acylsphinganine + CoA + H(+)
REACT:R-HSA-9664664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)
REACT:R-MMU-548815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Mus musculus)
REACT:R-RNO-450434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Rattus norvegicus)
REACT:R-XTR-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Xenopus tropicalis)
RHEA:36207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA
REACT:R-SSC-5685604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF6 binds SLAMF6 (Sus scrofa)
REACT:R-SSC-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Sus scrofa)
RHEA:47941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)) + H2O => ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine
REACT:R-SSC-3245898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds correnoids in the circulation (Sus scrofa)
RHEA:70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(out) => L-methionine(in)
RHEA:43185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2843) in 25S rRNA => H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine
RHEA:28006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(alpha)-methyl-L-tryptophan + O2 = formaldehyde + H2O2 + L-tryptophan
RHEA:68972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + sn-glycerol 3-phosphate = AH2 + dihydroxyacetone phosphate
REACT:R-SSC-2168923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XVIII endostatin release (Sus scrofa)
RHEA:17509	skos:prefLabel	"aminopyrimidine aminohydrolase"
RHEA:17509	skos:altLabel	"thiaminase"
RHEA:17509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminopyrimidine aminohydrolase"
RHEA:17509	skos:altLabel	"thiaminase II"
RHEA:17509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)
RHEA:17509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)
RHEA:39840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA
REACT:R-MMU-4085296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NCOA1 with SUMO1 (Mus musculus)
RHEA:37544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-chlorophenol + O2 => 2-amino-5-chloromuconate 6-semialdehyde
REACT:R-SSC-561072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal uptake of organic cations (Sus scrofa)
REACT:R-CEL-163741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Caenorhabditis elegans)
REACT:R-DDI-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Dictyostelium discoideum)
REACT:R-DRE-2002428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen N-propeptides (Danio rerio)
REACT:R-MMU-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)
REACT:R-SSC-169904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3G stimulates nucleotide exchange on Rap1 (Sus scrofa)
REACT:R-SSC-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Sus scrofa)
REACT:R-MMU-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Mus musculus)
RHEA:56056	skos:prefLabel	"isoflavone 7-O-glucosyltransferase"
RHEA:56056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoflavone 7-O-glucosyltransferase"
RHEA:56056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein + UDP-alpha-D-glucose = genistein 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-RNO-373791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Rattus norvegicus)
GO:0045294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-catenin binding
REACT:R-DME-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Drosophila melanogaster)
REACT:R-HSA-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Homo sapiens)
REACT:R-BTA-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Bos taurus)
REACT:R-HSA-6807578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface in the phagosome (Homo sapiens)
RHEA:67502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine
REACT:R-BTA-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)
REACT:R-DRE-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Danio rerio)
REACT:R-GGA-217150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of FancD2 (Gallus gallus)
REACT:R-BTA-6803761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Bos taurus)
REACT:R-MMU-8851352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR8 binds CCL1 (Mus musculus)
GO:0016296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-[acyl-carrier protein] hydrolase activity
GO:0016296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-ACP hydrolase activity
GO:0016296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-[acyl-carrier-protein] hydrolase activity
RHEA:10013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2
REACT:R-SPO-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Schizosaccharomyces pombe)
RHEA:49444	skos:prefLabel	"2-aminobenzoylacetyl-CoA thioesterase"
RHEA:49444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-aminobenzoylacetyl-CoA thioesterase"
RHEA:49444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA + H(+)
RHEA:39128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH
REACT:R-GGA-5606996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds activated protein C (Gallus gallus)
REACT:R-PFA-450984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Plasmodium falciparum)
RHEA:56914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+)
REACT:R-BTA-201712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin:TCF associates with BCL9 and PYGO (Bos taurus)
GO:0050139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:nicotinate N-glucosyltransferase activity
GO:0050139	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nicotinate glucosyltransferase activity
GO:0050139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:nicotinate N-glucosyltransferase activity
GO:0050139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate-N-glucosyltransferase activity
GO:0050139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-nicotinate N-glucosyltransferase activity
GO:0050139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:nicotinic acid-N-glucosyltransferase activity
RHEA:14906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate => 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine
RHEA:35469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+) => (6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin
REACT:R-GGA-5610767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Gallus gallus)
RHEA:41280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoylsphing-4-enine => octadecanoate + sphing-4-enine
RHEA:21542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate => N-(5-phospho-beta-D-ribosyl)anthranilate
REACT:R-XTR-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Xenopus tropicalis)
GO:0051538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triiron tetrasulphide cluster binding
GO:0051538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3Fe-4S cluster binding
GO:0051538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulfur cluster 3Fe-4S binding
GO:0051538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 iron, 4 sulfur cluster binding
GO:0051538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triiron tetrasulfide cluster binding
GO:0051538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Fe 4 S cluster binding
GO:0051538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 iron, 4 sulphur cluster binding
GO:0051538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulphur cluster 3Fe-4S binding
REACT:R-BTA-8956684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH polyubiquitinates TP73 (Bos taurus)
GO:0052857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPHX epimerase activity
RHEA:48918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GD1c + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b
RHEA:61319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-73596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => dUMP + NH4+ (Drosophila melanogaster)
REACT:R-DME-194023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2,HSD11B1 dimer oxidise CORT to COR (Drosophila melanogaster)
REACT:R-RNO-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Rattus norvegicus)
RHEA:66273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate
REACT:R-DDI-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)
REACT:R-RNO-6805205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR35 binds kynurenic acid (Rattus norvegicus)
RHEA:20070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenylacetaldehyde oxime => H2O + phenylacetonitrile
REACT:R-RNO-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Rattus norvegicus)
RHEA:43437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen III + 3 O2 => coproporphyrin III + 3 H2O2
REACT:R-XTR-9749471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 binds CHUK:IKBKB:IKBKG (Xenopus tropicalis)
RHEA:17266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-aconitate => cis-aconitate
RHEA:35385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine => precorrin-6B + S-adenosyl-L-methionine
RHEA:20005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-glucuronidase"
RHEA:20005	skos:altLabel	"alpha-glucosiduronase"
RHEA:20005	skos:prefLabel	"alpha-glucuronidase"
RHEA:20005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate
REACT:R-PFA-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Plasmodium falciparum)
REACT:R-MMU-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Mus musculus)
REACT:R-CFA-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Canis familiaris)
RHEA:33204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-SSC-9025996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Sus scrofa)
RHEA:21366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 6-aminohexanoate => H2O + N-(6-aminohexanoyl)-6-aminohexanoate
RHEA:48579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorocatechol + O2 <=> 3-chloro-cis,cis-muconate + 2 H(+)
REACT:R-HSA-3322431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds TLE (Homo sapiens)
RHEA:23266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+)
REACT:R-CFA-8854466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds RELN (Canis familiaris)
RHEA:65276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-1247497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds neuregulins (Xenopus tropicalis)
RHEA:33809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-4-vinylphenol + CO2 => (E)-ferulate + H(+)
GO:0062070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAGA complex binding
REACT:R-MMU-6785732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)
REACT:R-GGA-5693615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Gallus gallus)
REACT:R-CFA-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Canis familiaris)
RHEA:37496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-MMU-9658445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Mus musculus)
REACT:R-BTA-6811411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the Golgi (Bos taurus)
GO:0048000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)
GO:0048000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoflavone 3'-monooxygenase activity
GO:0048000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoflavone 3'-hydroxylase activity
REACT:R-XTR-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:71435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic L-alpha-amino acid(in) + L-thyroxine(out) = an aromatic L-alpha-amino acid(out) + L-thyroxine(in)
RHEA:36704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,5S)-5-carboxymethylproline + ATP => (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)
RHEA:48315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + H(+) + NADPH + O2 <=> 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)
REACT:R-CEL-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Caenorhabditis elegans)
RHEA:37494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine
RHEA:12881	skos:altLabel	"GGPS"
RHEA:12881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + sn-glycerol 3-phosphate = 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)
RHEA:12881	skos:altLabel	"glucosyl-glycerol-phosphate synthase"
RHEA:12881	skos:prefLabel	"glucosylglycerol-phosphate synthase"
RHEA:12881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosylglycerol-phosphate synthase"
RHEA:12881	skos:altLabel	"GG-phosphate synthase"
REACT:R-BTA-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Bos taurus)
RHEA:71550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphomethyl-dUMP in DNA + glycine <=> 5-N(alpha)-glycyl-dTMP in DNA + phosphate
REACT:R-HSA-379977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)
REACT:R-MMU-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Mus musculus)
GO:0047575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)
GO:0047575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxymuconolactone decarboxylase activity
GO:0047575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxymonolactone carboxy-lyase activity
GO:0047575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-4-carboxymuconolactone decarboxylase activity
GO:0047575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxymuconolactone carboxy-lyase activity
REACT:R-DME-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Drosophila melanogaster)
REACT:R-HSA-74065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT1-GTP binds PDE6 and activates it (Homo sapiens)
RHEA:41441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 => (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate
RHEA:65832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate
REACT:R-CFA-5675947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF18 binds TNFRSF18 (Canis familiaris)
REACT:R-RNO-1295599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 translocates to the plasma membrane (Rattus norvegicus)
REACT:R-CEL-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Caenorhabditis elegans)
REACT:R-HSA-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Homo sapiens)
REACT:R-CFA-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Canis familiaris)
RHEA:16340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Sus scrofa)
REACT:R-BTA-8983378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Bos taurus)
REACT:R-SSC-5634750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Sus scrofa)
RHEA:60604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline
REACT:R-SSC-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Sus scrofa)
RHEA:44304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA = a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
RHEA:26255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + isopimara-7,15-dienal + NADP(+) => H(+) + isopimara-7,15-dienol + NADPH + O2
GO:0004144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity
GO:0004144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diglyceride acyltransferase activity
GO:0004144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:1,2-diacylglycerol O-acyltransferase activity
GO:0004144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol O-acyltransferase activity
GO:0004144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diacylglycerol acyltransferase activity
GO:0004144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diglyceride O-acyltransferase activity
GO:0004144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-diacylglycerol acyltransferase activity
REACT:R-BTA-9700120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTN and MDK bind to PTPRZ (Bos taurus)
REACT:R-SSC-1964501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Sus scrofa)
RHEA:38306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate 6-phosphate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)
REACT:R-RNO-3149563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Rattus norvegicus)
RHEA:57718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamate + H(+) + H2O => hydrogencarbonate + NH4(+)
REACT:R-MMU-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Mus musculus)
REACT:R-HSA-5688289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Homo sapiens)
RHEA:10396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-amino-acid dehydrogenase"
RHEA:10396	skos:prefLabel	"L-amino-acid dehydrogenase"
RHEA:10396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + H2O + NAD(+) = a 2-oxocarboxylate + H(+) + NADH + NH4(+)
REACT:R-CFA-8848215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Canis familiaris)
RHEA:50930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2
REACT:R-HSA-1855176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Homo sapiens)
RHEA:23131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate
REACT:R-MMU-983145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Mus musculus)
REACT:R-DRE-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Danio rerio)
REACT:R-CFA-174451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of DNA2 endonuclease to the C strand (Canis familiaris)
REACT:R-BTA-210304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with PECAM1 (Bos taurus)
RHEA:48074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM1 (d18:1(4E)) + H2O
REACT:R-HSA-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Homo sapiens)
REACT:R-GGA-421426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ProGIP translocates from the ER Lumen to secretory granules (Gallus gallus)
RHEA:27500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-O-methyltricetin + S-adenosyl-L-methionine <=> 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Drosophila melanogaster)
REACT:R-MMU-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Mus musculus)
REACT:R-BTA-8951500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CANX from nonameric complex (Bos taurus)
RHEA:11122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + NH4(+) => cyanate + 3 H(+) + hydrogencarbonate
REACT:R-MMU-3149539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Mus musculus)
GO:0034072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene cyclase activity
REACT:R-XTR-9632033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GalNAc to chondroitin (Xenopus tropicalis)
GO:0004793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine acetaldehyde-lyase (glycine-forming)
GO:0004793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine aldolase activity
GO:0004793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine aldolase activity
GO:0004793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine acetaldehyde-lyase activity
REACT:R-MMU-5684836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC1B dimer binds PDPN (Mus musculus)
RHEA:30377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-thujopsene + diphosphate => (2E,6E)-farnesyl diphosphate
GO:0102469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naringenin 2-hydroxylase activity
RHEA:30460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone
REACT:R-HSA-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Homo sapiens)
RHEA:35441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaetidylserine + CMP + H(+) => CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
REACT:R-DRE-1475028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Danio rerio)
REACT:R-CFA-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Canis familiaris)
RHEA:24740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)
RHEA:12867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methyladenine + D-ribose => 1-methyladenosine + H2O
REACT:R-HSA-2089971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of collagens (Homo sapiens)
RHEA:18789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine 6-phosphate = D-galactosamine 6-phosphate
RHEA:18789	skos:prefLabel	"D-glucosamine-6-phosphate 4-epimerase"
RHEA:18789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glucosamine-6-phosphate 4-epimerase"
REACT:R-DRE-6789092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide anion from oxygen (Danio rerio)
REACT:R-MMU-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Mus musculus)
RHEA:10686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[protein] + phosphate => H2O + O-phospho-L-tyrosyl-[protein]
REACT:R-RNO-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Rattus norvegicus)
REACT:R-DRE-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Danio rerio)
REACT:R-RNO-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Rattus norvegicus)
REACT:R-BTA-209566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is auto-ubiquitinated (Bos taurus)
REACT:R-DRE-9007926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATRX binds DAXX (Danio rerio)
GO:0102591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity
REACT:R-DME-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Drosophila melanogaster)
REACT:R-GGA-571316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex.  (Gallus gallus)
REACT:R-DRE-9614271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ADGRG6 (Danio rerio)
REACT:R-DRE-1168638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated IKK phosphorylates I-kappaB (Danio rerio)
REACT:R-GGA-416985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to synapse (Gallus gallus)
GO:0035715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine (C-C motif) ligand 2 binding
GO:0035715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCL2 binding
REACT:R-GGA-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Gallus gallus)
REACT:R-RNO-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Rattus norvegicus)
REACT:R-CFA-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Canis familiaris)
GO:0034236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase A catalytic subunit binding
GO:0034236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA catalytic subunit binding
RHEA:28609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
GO:0051746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thalianol synthase activity
RHEA:43557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
REACT:R-CFA-211983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2J2 oxidises ARA (Canis familiaris)
RHEA:38969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate => an N-acylsphing-4-enine(in) + ATP + H2O
REACT:R-DRE-1250264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP binds reduced thioredoxin (Danio rerio)
RHEA:61529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base => a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base
REACT:R-RNO-9623384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-agonists bind ADRA1A,B,D (Rattus norvegicus)
RHEA:42531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(955/2504/2580) in 23S rRNA <=> pseudouridine(955/2504/2580) in 23S rRNA
REACT:R-PFA-203553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS binds NOSIP (Plasmodium falciparum)
RHEA:13776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-9008928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Xenopus tropicalis)
REACT:R-CFA-5638006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3 hydrolyzes GTP (Canis familiaris)
RHEA:29713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine(out) + H(+)(out) => cadaverine(in) + H(+)(in)
RHEA:32594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O <=> (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)
RHEA:25486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-camphene + diphosphate => (2E)-geranyl diphosphate
REACT:R-HSA-8980228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Homo sapiens)
REACT:R-BTA-947673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanin-concentrating hormone receptors bind MCH (Bos taurus)
RHEA:61384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate
RHEA:37666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP
GO:0016286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SK KCa channels
GO:0016286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conductance KCa channels
GO:0016286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conductance calcium-activated potassium channel activity
GO:0016286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SK calcium-activated potassium channel activity
REACT:R-HSA-2309773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)
RHEA:59315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + O2 <=> D-galactono-1,5-lactone + H2O2
GO:0052815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	medium-chain acyl-CoA hydrolase activity
GO:0052815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	medium-chain acyl-thioester hydrolase activity
GO:0052815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	medium-chain hydrolase activity
GO:0052815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	medium-chain-acyl-CoA hydrolase activity
GO:0052815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	medium-chain acyl coenzyme A hydrolase activity
REACT:R-SSC-5687120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Sus scrofa)
REACT:R-XTR-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Xenopus tropicalis)
RHEA:17796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-tRNA(Thr) <=> H(+) + L-alanine + tRNA(Thr)
EC:3.4.24.18	skos:altLabel	"endopeptidase-2"
EC:3.4.24.18	skos:prefLabel	"meprin A"
EC:3.4.24.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"meprin A"
REACT:R-HSA-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Homo sapiens)
RHEA:58130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine
REACT:R-BTA-1254386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 forms a complex with estrogen receptor ESR1 (Bos taurus)
REACT:R-SSC-72185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA polyadenylation (Sus scrofa)
REACT:R-DME-214860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
RHEA:40550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]
EC:1.3.1.n3	skos:altLabel	"NADPH-dependent curcumin/dihydrocurcumin reductase"
EC:1.3.1.n3	skos:prefLabel	"curcumin reductase"
EC:1.3.1.n3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"curcumin reductase"
GO:0062193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose pyranase activity
REACT:R-XTR-6811454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate PP2A (Xenopus tropicalis)
RHEA:57902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2
GO:0016829	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	other lyase activity
GO:0016829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lyase activity
REACT:R-SPO-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Schizosaccharomyces pombe)
REACT:R-RNO-400037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi,Go Heterotrimeric G-protein complex dissociates (Rattus norvegicus)
RHEA:71097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + pregnenolone sulfate(in) => 2 Na(+)(out) + pregnenolone sulfate(out)
RHEA:21582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-acetoin + CO2 => (2S)-2-acetolactate + H(+)
GO:0140833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain Y1 kinase activity
REACT:R-SSC-8847579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD5 desaturates ST-CoA to OLE-CoA (Sus scrofa)
REACT:R-XTR-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Xenopus tropicalis)
REACT:R-MMU-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Mus musculus)
REACT:R-MMU-9014433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GEFs activate RHOG (Mus musculus)
RHEA:68794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + H(+) + nicotinamide => alpha-NAD(+) + H2O
REACT:R-BTA-205238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 interacts with p-KIT (Bos taurus)
REACT:R-CFA-8950179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B translocates from the cytosol to the extracellular region (Canis familiaris)
REACT:R-SCE-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)
RHEA:43334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine
REACT:R-HSA-210285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homophilic interaction of PECAM-1 (Homo sapiens)
REACT:R-XTR-158468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates PARA to PARA-SO4 (Xenopus tropicalis)
REACT:R-CFA-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Canis familiaris)
RHEA:54617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + heptadecanoyl-CoA + O2 => 2-hydroxyheptadecanoyl-CoA + CO2 + succinate
RHEA:39294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA
RHEA:24959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate
REACT:R-HSA-9708466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y486 BACH1 translocates from the nucleoplasm to the cytosol (Homo sapiens)
REACT:R-GGA-2213201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibres (Gallus gallus)
REACT:R-MMU-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Mus musculus)
REACT:R-DDI-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Dictyostelium discoideum)
RHEA:38759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:14967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + H(+) + phosphate => an acyl phosphate + H2O
REACT:R-HSA-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Homo sapiens)
RHEA:42167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O
REACT:R-SSC-9638120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU4 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)
RHEA:52923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-SPO-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Schizosaccharomyces pombe)
REACT:R-XTR-159761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Xenopus tropicalis)
REACT:R-XTR-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Xenopus tropicalis)
RHEA:39073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenedioyl-CoA + H2O2 => dodecanedioyl-CoA + O2
GO:0018717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-phenanthrol glycosyltransferase activity
RHEA:49409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-mannosyl](n) + phosphate => [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate
REACT:R-SSC-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Sus scrofa)
REACT:R-SSC-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Sus scrofa)
REACT:R-MMU-5654399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS2 (Mus musculus)
RHEA:44527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)
REACT:R-SSC-9707659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes:LY96 activates TLR4 (Sus scrofa)
RHEA:38389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-GGA-9693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds 5HT (Gallus gallus)
REACT:R-CEL-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Caenorhabditis elegans)
RHEA:38486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)
REACT:R-RNO-8862090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Rattus norvegicus)
REACT:R-HSA-5687115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYC positively regulates MAPKAPK5 gene expression (Homo sapiens)
RHEA:23175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] <=> ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]
REACT:R-HSA-2033479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of FGFR2 point mutants with enhanced kinase activity (Homo sapiens)
RHEA:10974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-hexose 1-phosphate + NH4(+) => D-hexose + H(+) + phosphoramidate
REACT:R-XTR-909724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IFNAR1 (Xenopus tropicalis)
REACT:R-DME-8869580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEK binds TFAP2A homodimers (Drosophila melanogaster)
REACT:R-CEL-6809707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTMR2 (Caenorhabditis elegans)
RHEA:15225	skos:altLabel	"dTDP-glucose synthase"
RHEA:15225	skos:altLabel	"dTDP-glucose diphosphorylase"
RHEA:15225	skos:altLabel	"dTDP-glucose pyrophosphorylase"
RHEA:15225	skos:prefLabel	"glucose-1-phosphate thymidylyltransferase"
RHEA:15225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-1-phosphate thymidylyltransferase"
RHEA:15225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose
RHEA:15187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(2)-succinyl-L-arginine => L-arginine + succinyl-CoA
REACT:R-CFA-114307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SMAC (DIABLO) from mitochondria (Canis familiaris)
RHEA:53085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP
RHEA:19132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thymidine <=> ADP + dTMP + H(+)
REACT:R-MMU-453183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y348-SYK dissociates (Mus musculus)
REACT:R-CFA-5654426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
REACT:R-BTA-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
REACT:R-HSA-388605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMC(138-176) binds MC2R (Homo sapiens)
RHEA:58154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + phosphonoacetate => H2O + NAD(+) + phosphonoacetaldehyde
RHEA:59425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylamine + H2O + O2 => benzaldehyde + H2O2 + NH4(+)
RHEA:12650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnofuranose + NAD(+) => H(+) + L-rhamnono-1,4-lactone + NADH
RHEA:63993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-fluorocytidine + ATP => 5-fluorocytidine 5'-phosphate + ADP + H(+)
RHEA:38981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-SCE-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Saccharomyces cerevisiae)
REACT:R-HSA-420595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-2:Nectin 3 trans heterodimer interaction (Homo sapiens)
GO:0102764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxotyphasterol C-23 hydroxylase activity
REACT:R-SPO-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Schizosaccharomyces pombe)
RHEA:12345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) => H(+) + L-glutamyl-tRNA(Glu) + NADPH
RHEA:61551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:28443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP] => dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]
RHEA:31384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => lupeol
RHEA:51720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)
RHEA:33802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidinol + NAD(+) <=> H(+) + L-histidinal + NADH
RHEA:16050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide-GDP + alpha-ribazole => adenosylcob(III)alamin + GMP + H(+)
RHEA:37715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine = 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:27837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + succinate <=> a menaquinol + fumarate
REACT:R-PFA-9624778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD 12mer translocates from ER membrane to extracellular region (Plasmodium falciparum)
REACT:R-CFA-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)
RHEA:14547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + nicotinate => H2O + nicotinamide
RHEA:22248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH
RHEA:22248	skos:prefLabel	"kynurenate-7,8-dihydrodiol dehydrogenase"
RHEA:22248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kynurenate-7,8-dihydrodiol dehydrogenase"
REACT:R-RNO-110231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by MBD4 glycosylase (Rattus norvegicus)
RHEA:16499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine
RHEA:16054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine => H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP
REACT:R-BTA-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Bos taurus)
RHEA:50715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + O2 + tetracycline <=> 7-chlorotetracycline + FAD + H(+) + 2 H2O
REACT:R-HSA-6793057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841 (Homo sapiens)
RHEA:46261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:31797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-caryolan-1-ol => (+)-(E)-beta-caryophyllene + H2O
REACT:R-CFA-3132759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds RCbl (Canis familiaris)
RHEA:56833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) => 2,3,6-trichlorohydroquinone + 2 glutathione
REACT:R-HSA-1296035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Homo sapiens)
RHEA:70157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:65874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyandrostan-1,3-dione + AH2 => 1,17beta-dihydroxyandrostan-3-one + A
REACT:R-DRE-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Danio rerio)
REACT:R-HSA-202331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to SLP-76 (Homo sapiens)
REACT:R-SSC-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)
REACT:R-RNO-1602399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLB1 (Rattus norvegicus)
RHEA:45556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine
REACT:R-MMU-8857692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA demethylases demethylate N6-methyladenosine RNA (Mus musculus)
REACT:R-SSC-6805399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAF1 phosphorylates TP53 (Sus scrofa)
RHEA:29865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + GDP => AMP + GTP
REACT:R-SPO-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Schizosaccharomyces pombe)
REACT:R-HSA-1497853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Homo sapiens)
REACT:R-XTR-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Xenopus tropicalis)
GO:0008261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allatostatin receptor activity
REACT:R-CEL-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)
REACT:R-DRE-9661408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Danio rerio)
REACT:R-DRE-8866283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBB recruits GPCRs into clathrin-coated pits (Danio rerio)
RHEA:44518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O
REACT:R-CFA-6784399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Canis familiaris)
RHEA:29725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate(out) => glyoxylate(in)
RHEA:56851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-didemethyltoxoflavin + S-adenosyl-L-methionine <=> H(+) + reumycin + S-adenosyl-L-homocysteine
REACT:R-MMU-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
REACT:R-XTR-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Xenopus tropicalis)
REACT:R-RNO-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Rattus norvegicus)
RHEA:10570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + luteolin 7-O-beta-D-glucuronide + UDP => luteolin + UDP-alpha-D-glucuronate
REACT:R-DME-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)
RHEA:42914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine
RHEA:34051	skos:prefLabel	"2'''-acetyl-6'''-hydroxyneomycin C deacetylase"
RHEA:34051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'''-acetyl-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate
RHEA:34051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'''-acetyl-6'''-hydroxyneomycin C deacetylase"
RHEA:39097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydecanedioyl-CoA + NAD(+)
RHEA:59856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetramethylammonium--corrinoid protein Co-methyltransferase"
RHEA:59856	skos:prefLabel	"tetramethylammonium--corrinoid protein Co-methyltransferase"
RHEA:59856	skos:altLabel	"tetramethylammonium methyltransferase"
RHEA:59856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium = methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine
GO:0000403	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	forked DNA binding
GO:0000403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	splayed Y-form DNA binding
GO:0000403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y-form DNA binding
REACT:R-RNO-5690701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 binds p-CD22 (Rattus norvegicus)
REACT:R-HSA-6794356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BEGAIN binds DLG2,DLG3,DLG4 (Homo sapiens)
RHEA:47232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:15102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + meso-2,6-diaminoheptanedioate => CO2 + L-lysine
RHEA:12921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA
RHEA:12921	skos:prefLabel	"5-aminolevulinate synthase"
RHEA:12921	skos:altLabel	"ALAS"
RHEA:12921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-aminolevulinate synthase"
RHEA:12921	skos:altLabel	"delta-ALA synthetase"
RHEA:12921	skos:altLabel	"5-aminolevulinic acid synthase"
RHEA:12921	skos:altLabel	"delta-aminolevulinate synthase"
RHEA:21747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine <=> 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine
REACT:R-GGA-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Gallus gallus)
REACT:R-CFA-205319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of APS and p-KIT (Canis familiaris)
REACT:R-BTA-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Bos taurus)
REACT:R-BTA-8944219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVI (Bos taurus)
RHEA:36197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O
RHEA:65921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
RHEA:50663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O
REACT:R-HSA-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Homo sapiens)
REACT:R-GGA-141439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of activated MAD2 from kinetochores (Gallus gallus)
GO:0050080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA carboxy-lyase activity
GO:0050080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA decarboxylase activity
GO:0050080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA carboxy-lyase (acetyl-CoA-forming)
GO:0050080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl coenzyme A decarboxylase activity
RHEA:26548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + NH4(+) => beta-alaninamide + H2O
REACT:R-DME-5618093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP90 (Drosophila melanogaster)
REACT:R-CFA-4420083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Canis familiaris)
REACT:R-BTA-416985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to synapse (Bos taurus)
REACT:R-PFA-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Plasmodium falciparum)
RHEA:12983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + 2 H(+) + sulfite => H2O + O2 + S-sulfanylglutathione
REACT:R-DME-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Drosophila melanogaster)
RHEA:35636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP
RHEA:32084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + pseudaminate => CMP-pseudaminate + diphosphate
RHEA:36546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mycothiol S-conjugate <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate
GO:0019772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	low affinity Fc receptor activity
GO:0019772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity IgG receptor activity
GO:0019772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity IgG receptor activity
REACT:R-BTA-2187401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 dephosphorylates SMAD2/3 (Bos taurus)
REACT:R-CEL-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Caenorhabditis elegans)
REACT:R-HSA-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Homo sapiens)
GO:0102600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity
RHEA:70263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
RHEA:31474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP
RHEA:23348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-carboxymuconolactone decarboxylase"
RHEA:23348	skos:prefLabel	"4-carboxymuconolactone decarboxylase"
RHEA:23348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2
RHEA:23348	skos:altLabel	"4-carboxymuconolactone carboxy-lyase"
REACT:R-DDI-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Dictyostelium discoideum)
RHEA:48275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-BTA-2471621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin degradation by cathepsins (Bos taurus)
REACT:R-DME-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Drosophila melanogaster)
RHEA:48669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0033707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-deamino-3''-oxonicotianamine reductase activity
GO:0033707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity
REACT:R-DRE-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Danio rerio)
REACT:R-BTA-158218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Bos taurus)
REACT:R-SSC-428231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Sus scrofa)
REACT:R-SSC-8940554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2 cleaves OPTC (Sus scrofa)
REACT:R-DME-398185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG binds plexin B1 (Drosophila melanogaster)
REACT:R-XTR-3204318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Xenopus tropicalis)
RHEA:65956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + estrone 3-sulfate(out) + H2O = ADP + estrone 3-sulfate(in) + H(+) + phosphate
REACT:R-CFA-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Canis familiaris)
REACT:R-CFA-6814409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates PDCL (Canis familiaris)
RHEA:38143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carbon disulfide hydrolase"
RHEA:38143	skos:altLabel	"carbon disulfide lyase"
RHEA:38143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon disulfide + 2 H2O = CO2 + 2 H(+) + 2 hydrogen sulfide
RHEA:38143	skos:prefLabel	"carbon disulfide hydrolase"
RHEA:38143	skos:altLabel	"CS2-converting enzyme"
RHEA:38143	skos:altLabel	"CS2 hydrolase"
REACT:R-SSC-9624778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD 12mer translocates from ER membrane to extracellular region (Sus scrofa)
REACT:R-BTA-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Bos taurus)
RHEA:39068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanedioyl-CoA + CoA => acetyl-CoA + hexanedioyl-CoA
REACT:R-DRE-194632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Danio rerio)
REACT:R-GGA-5654562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Gallus gallus)
RHEA:34990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(in) <=> (S)-lactate(out)
RHEA:46939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) <=> ATP + H(+) + L-2-aminoadipate + NADPH
REACT:R-SSC-5603467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C is released from PROCR (Sus scrofa)
REACT:R-PFA-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Plasmodium falciparum)
REACT:R-SSC-174451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of DNA2 endonuclease to the C strand (Sus scrofa)
REACT:R-HSA-909776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + pyruvate => 3-oxopropanoate + alanine (Homo sapiens)
REACT:R-DME-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Drosophila melanogaster)
RHEA:22406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactaro-1,5-lactone + H(+) + NADH => beta-D-galacturonate + NAD(+)
GO:0047954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol-2-phosphate phosphohydrolase activity
GO:0047954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glycerophosphate phosphatase activity
GO:0047954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-2-phosphatase activity
GO:0047954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-glycerophosphatase activity
GO:0047954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glycerophosphatase activity
RHEA:29853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-galactosamine
RHEA:54945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)
RHEA:36170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate
REACT:R-RNO-9026894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK2 (Rattus norvegicus)
REACT:R-RNO-111804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)
REACT:R-XTR-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Xenopus tropicalis)
REACT:R-DDI-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)
REACT:R-HSA-109671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Homo sapiens)
REACT:R-DRE-4568863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RAD52 with SUMO1 (Danio rerio)
REACT:R-SSC-9020251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Sus scrofa)
RHEA:22686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2
RHEA:66141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + octopamine => CoA + H(+) + N-acetyloctopamine
RHEA:71796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate(out) + H(+)(out) => (R)-3-hydroxybutanoate(in) + H(+)(in)
REACT:R-XTR-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Xenopus tropicalis)
RHEA:60299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-MMU-1602473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP1 (Mus musculus)
EC:1.5.1.42	skos:prefLabel	"FMN reductase (NADH)"
EC:1.5.1.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FMN reductase (NADH)"
EC:1.5.1.42	skos:altLabel	"NADH-dependent FMN reductase"
RHEA:66700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate
REACT:R-HSA-203156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-derived TREM-1 ligand binds to TREM-1 (Homo sapiens)
RHEA:39155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O
RHEA:42731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2791) in 21S rRNA <=> 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-114670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)
RHEA:53919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acyl-L-lysyl-[protein]
REACT:R-HSA-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Homo sapiens)
REACT:R-SSC-5693593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop extension by DNA polymerases (Sus scrofa)
REACT:R-SSC-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Sus scrofa)
REACT:R-RNO-443418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b signaling involves c-Src (Rattus norvegicus)
REACT:R-CFA-420739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPRC6A can bind L-alpha amino acids and calcium (Canis familiaris)
RHEA:59140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + N(5)-[(S)-citryl]-D-ornithine = AMP + diphosphate + H(+) + staphyloferrin A
RHEA:59140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"staphyloferrin A synthase"
RHEA:59140	skos:prefLabel	"staphyloferrin A synthase"
RHEA:13452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH
REACT:R-RNO-9657619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)
REACT:R-DDI-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Dictyostelium discoideum)
RHEA:42467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2',3-triol + O2 <=> 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)
REACT:R-CFA-2066779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Canis familiaris)
REACT:R-RNO-9732527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds rosiglitazone (Rattus norvegicus)
REACT:R-DRE-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Danio rerio)
RHEA:12117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2 => AH2
RHEA:72302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)
REACT:R-DDI-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Dictyostelium discoideum)
RHEA:63731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	candesartan + UDP-alpha-D-glucuronate <=> candesartan-2-N-beta-D-glucuronide + UDP
REACT:R-CFA-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Canis familiaris)
GO:0050037	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-xylose:NADP+ 1-oxidoreductase activity
GO:0050037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-xylose 1-dehydrogenase"
GO:0050037	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-xylose reductase activity
GO:0050037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylose + NADP(+) = H(+) + L-xylono-1,4-lactone + NADPH
GO:0050037	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-xylose dehydrogenase activity
GO:0050037	skos:prefLabel	"L-xylose 1-dehydrogenase"
GO:0050037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylose 1-dehydrogenase activity
GO:0004102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline acetylase activity
GO:0004102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline acetyltransferase activity
GO:0004102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline O-acetyltransferase activity
GO:0004102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:choline O-acetyltransferase activity
GO:0004102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CHOACTase activity
REACT:R-DRE-265426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Tenascin (Danio rerio)
RHEA:59640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotetraose + O2 = D-xylotetraono-1,5-lactone + H2O2
REACT:R-DME-199425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)
RHEA:67811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine
REACT:R-BTA-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Bos taurus)
REACT:R-CFA-391913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR2 binds FPR2 ligands (Canis familiaris)
REACT:R-CFA-5658438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRED dimer binds NF1 (Canis familiaris)
REACT:R-GGA-140686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Gallus gallus)
RHEA:58713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + O2 + rifampicin => H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide
RHEA:34370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylamide + H2O <=> acrylate + NH4(+)
REACT:R-SSC-914018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Sus scrofa)
RHEA:56182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2 => 8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate
REACT:R-MMU-159046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Mus musculus)
REACT:R-XTR-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Xenopus tropicalis)
RHEA:34603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphinganine
REACT:R-CEL-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Caenorhabditis elegans)
RHEA:72052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) + estrone 3-sulfate(in) => butanoate(in) + estrone 3-sulfate(out)
REACT:R-RNO-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Rattus norvegicus)
RHEA:57492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate + propanoyl-CoA = 2-methylcitrate + CoA + H(+)
RHEA:34731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine
GO:0018615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-indanone monooxygenase activity
RHEA:25544	skos:prefLabel	"ent-pimara-9(11),15-diene synthase"
RHEA:25544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate = diphosphate + ent-pimara-9(11),15-diene
RHEA:25544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-pimara-9(11),15-diene synthase"
RHEA:25544	skos:altLabel	"PMD synthase"
RHEA:13513	skos:altLabel	"orotate reductase (NADH)"
RHEA:13513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroorotate dehydrogenase (NAD(+))"
RHEA:13513	skos:altLabel	"DHODase"
RHEA:13513	skos:altLabel	"DHOdehase"
RHEA:13513	skos:altLabel	"DHOD"
RHEA:13513	skos:altLabel	"orotate reductase (NADH2)"
RHEA:13513	skos:prefLabel	"dihydroorotate dehydrogenase (NAD(+))"
RHEA:13513	skos:altLabel	"dihydroorotate oxidase"
RHEA:13513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate
RHEA:58522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:38977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:36169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 5'-phosphate + H2O
REACT:R-SSC-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Sus scrofa)
REACT:R-RNO-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Rattus norvegicus)
RHEA:10265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose => beta-D-glucose
REACT:R-HSA-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)
REACT:R-HSA-193072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)
EC:5.4.4.7	skos:prefLabel	"hydroperoxy icosatetraenoate isomerase"
EC:5.4.4.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroperoxy icosatetraenoate isomerase"
EC:5.4.4.7	skos:altLabel	"epidermal lipoxygenase-3"
RHEA:11740	skos:altLabel	"glutathione reductase (NADPH)"
RHEA:11740	skos:altLabel	"NADPH-GSSG reductase"
RHEA:11740	skos:altLabel	"NADPH:oxidized-glutathione oxidoreductase"
RHEA:11740	skos:altLabel	"GSH reductase"
RHEA:11740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH
RHEA:11740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione-disulfide reductase"
RHEA:11740	skos:altLabel	"glutathione reductase"
RHEA:11740	skos:altLabel	"NADPH-glutathione reductase"
RHEA:11740	skos:altLabel	"glutathione S-reductase"
RHEA:11740	skos:altLabel	"GSSG reductase"
RHEA:11740	skos:prefLabel	"glutathione-disulfide reductase"
RHEA:33746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine 1-phosphate + H2O <=> an N-acylsphing-4-enine + phosphate
RHEA:20650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23,24-dihydrocucurbitacin B + NADP(+) => cucurbitacin B + H(+) + NADPH
REACT:R-CEL-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Caenorhabditis elegans)
RHEA:27471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine => H2O + N,N'-diacetylchitobiose
REACT:R-DRE-188979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Danio rerio)
RHEA:52447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)
REACT:R-HSA-9655086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF4 binds the DDIT3 promoter (Homo sapiens)
RHEA:30767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucurono-3,6-lactone + H2O = D-glucuronate + H(+)
GO:0102415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin gentiobioside 1,6-glucosyltransferase activity
RHEA:64061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-phenylacetylcarbinol + NAD(+) => 1-phenyl-1,2-propanedione + H(+) + NADH
RHEA:35009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fucose(out) => D-fucose(in)
RHEA:66422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + glutathione(in) + H2O + tauroursodeoxycholate(in)
REACT:R-HSA-9012209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive KPNA2 gene transcription (Homo sapiens)
RHEA:17965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) = (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O
RHEA:54429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O => ADP-D-ribose + H(+) + L-aspartyl-[protein]
REACT:R-RNO-3134804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING ubiquitination by TRIM32 or TRIM56 (Rattus norvegicus)
REACT:R-BTA-5654562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Bos taurus)
REACT:R-BTA-211923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26C1 4-hydroxylates 9cRA (Bos taurus)
RHEA:12887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp) => GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp)
EC:3.4.22.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gingipain K"
EC:3.4.22.47	skos:altLabel	"Lys-gingipain"
EC:3.4.22.47	skos:altLabel	"PrtP proteinase"
EC:3.4.22.47	skos:prefLabel	"gingipain K"
REACT:R-HSA-9769044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds IQSEC3 gene promoter (Homo sapiens)
RHEA:29254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + Na(+)(in) <=> 2 H(+)(in) + Na(+)(out)
REACT:R-BTA-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Bos taurus)
RHEA:19828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-aristolochene + diphosphate
RHEA:23652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)
RHEA:23652	skos:prefLabel	"glutaminyl-peptide cyclotransferase"
RHEA:23652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutaminyl-peptide cyclotransferase"
RHEA:23652	skos:altLabel	"glutaminyl-tRNA cyclotransferase"
RHEA:23652	skos:altLabel	"glutaminyl cyclase"
REACT:R-MMU-2160884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Mus musculus)
REACT:R-XTR-1250383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)
REACT:R-RNO-2045911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
REACT:R-BTA-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Bos taurus)
REACT:R-HSA-3240765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1/2/3:DP1/2 binds EED gene promoter (Homo sapiens)
REACT:R-DRE-114670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binds to vWF:Collagen complex (Danio rerio)
REACT:R-CFA-912727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds VAV (Canis familiaris)
GO:0033464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine tRNA
GO:0033464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGG codon-amino acid adaptor activity
RHEA:34269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + fumigaclavine A => acetyl-CoA + fumigaclavine B
REACT:R-HSA-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Homo sapiens)
REACT:R-BTA-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Bos taurus)
RHEA:48610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-dehydroacyl-CoA + AH2 => A + a 2,3-saturated acyl-CoA
RHEA:39309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH
REACT:R-CFA-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Canis familiaris)
RHEA:37186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
RHEA:13726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-D-glucosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate
REACT:R-XTR-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Xenopus tropicalis)
RHEA:43118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2
RHEA:49489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)
REACT:R-SCE-2993780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO1 from E1 to UBE2I (UBC9) (Saccharomyces cerevisiae)
RHEA:28720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine(in) + H(+)(in) => adenine(out) + H(+)(out)
RHEA:36662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + descarbamoylnovobiocin <=> novobiocin + phosphate
REACT:R-MMU-8870352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Mus musculus)
REACT:R-RNO-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Rattus norvegicus)
RHEA:14706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CoA + NADP(+) => CoA-disulfide + H(+) + NADPH
REACT:R-CFA-1011600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rabenosyn-5 connects  Rab5 to VPS-45 (Canis familiaris)
RHEA:61451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tigecycline <=> 11a-hydroxytigecycline + H2O + NADP(+)
REACT:R-HSA-5686359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPs translocate from extracellular region to clathrin-coated vesicle (Homo sapiens)
REACT:R-GGA-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Gallus gallus)
REACT:R-SSC-420214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The adrenomedullin receptor can bind adrenomedullin and intermedin (Sus scrofa)
RHEA:21205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol => a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester
REACT:R-CEL-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Caenorhabditis elegans)
RHEA:29516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)
REACT:R-BTA-73945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAS-mediated dimerization of procaspase-8 (Bos taurus)
GO:0050600	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myristoyl-CoA 11-(E) desaturase activity
GO:0050600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA 11-(E)-desaturase activity
GO:0050600	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acyl-CoA delta11-desaturase activity
RHEA:57427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guaiacol + O2 + reduced [NADH--hemoprotein reductase] <=> catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
RHEA:56905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-AMP + CoA => AMP + an acyl-CoA + H(+)
RHEA:61861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroprobetaenone I + H(+) + NADPH + O2 => epoxybetaenone + H2O + NADP(+)
RHEA:40164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + H2O + NADP(+) => (R)-glycerate + 2 H(+) + NADPH
GO:0031216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pullulan 4-D-glucanohydrolase (panose-forming)
GO:0031216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pullulanase II activity
GO:0031216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neopullulanase activity
REACT:R-MMU-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
REACT:R-DME-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Drosophila melanogaster)
REACT:R-GGA-352029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Gallus gallus)
RHEA:71180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(out) + L-tryptophan(in) => L-histidine(in) + L-tryptophan(out)
REACT:R-MMU-9017797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds YBX1 (Mus musculus)
RHEA:65481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + hexan-1-ol => CoA + hexyl 2-methylbutanoate
REACT:R-CFA-264458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of COP1 (Canis familiaris)
RHEA:55072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + H(+) = CO2 + propanal
REACT:R-XTR-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Xenopus tropicalis)
REACT:R-BTA-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Bos taurus)
REACT:R-DME-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Drosophila melanogaster)
RHEA:10184	skos:altLabel	"carboxymethylbutenolide lactonase"
RHEA:10184	skos:prefLabel	"3-oxoadipate enol-lactonase"
RHEA:10184	skos:altLabel	"3-oxoadipic enol-lactone hydrolase"
RHEA:10184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O = 3-oxoadipate + H(+)
RHEA:10184	skos:altLabel	"beta-ketoadipic enol-lactone hydrolase"
RHEA:10184	skos:altLabel	"3-ketoadipate enol-lactonase"
RHEA:10184	skos:altLabel	"beta-ketoadipate enol-lactone hydrolase"
RHEA:10184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxoadipate enol-lactonase"
REACT:R-CFA-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Canis familiaris)
REACT:R-XTR-445753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Xenopus tropicalis)
REACT:R-CFA-110360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to the AP site (Canis familiaris)
RHEA:48968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O
REACT:R-DRE-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Danio rerio)
GO:0004965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled GABA receptor activity
GO:0004965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GABA-B receptor activity
GO:0004965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	metabotropic GABA receptor
GO:0004965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled GABA receptor activity
REACT:R-MMU-430076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds 14-3-3-zeta (Mus musculus)
RHEA:39473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH
RHEA:21584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"propanediol-phosphate dehydrogenase"
RHEA:21584	skos:prefLabel	"propanediol-phosphate dehydrogenase"
RHEA:21584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH
REACT:R-XTR-8956659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates YAP1 (Xenopus tropicalis)
RHEA:19127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + glycine => glyoxylate + L-serine
GO:0030298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor signalling protein tyrosine kinase activator activity
GO:0030298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor signaling protein tyrosine kinase activator activity
REACT:R-HSA-1475022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)
EC:2.4.99.21	skos:altLabel	"dolichyl-monophosphooligosaccharide-protein glycotransferase"
EC:2.4.99.21	skos:prefLabel	"dolichyl-phosphooligosaccharide-protein glycotransferase"
EC:2.4.99.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-phosphooligosaccharide-protein glycotransferase"
EC:2.4.99.21	skos:altLabel	"archaeal oligosaccharyl transferase"
REACT:R-GGA-216068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with Tenascin-C (Gallus gallus)
REACT:R-MMU-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Mus musculus)
REACT:R-XTR-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Xenopus tropicalis)
RHEA:15051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + GDP + H(+) => GDP-alpha-D-glucose + H2O
REACT:R-HSA-5082384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70:DNAJB1 binds HSF1 (Homo sapiens)
GO:0034942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity
RHEA:21916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O = an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)
RHEA:14828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH
RHEA:27637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH
RHEA:17412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-coclaurine + S-adenosyl-L-methionine <=> (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-72619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2:GTP is hydrolyzed, eIFs are released  (Danio rerio)
RHEA:62882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2
REACT:R-MMU-870538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Mus musculus)
REACT:R-DDI-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Dictyostelium discoideum)
REACT:R-GGA-2730959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN7:OSTM1 exchanges Cl- for H+ (Gallus gallus)
RHEA:53316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
RHEA:53316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase"
RHEA:53316	skos:prefLabel	"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase"
RHEA:17369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycyrrhizinate beta-glucuronidase"
RHEA:17369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhizin + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate
RHEA:17369	skos:prefLabel	"glycyrrhizinate beta-glucuronidase"
REACT:R-DDI-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Dictyostelium discoideum)
GO:0047284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-xylosyl-phosphate-protein xylosyltransferase activity
GO:0047284	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity
GO:0099510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	regulation of cytosolic calcium ion concentration by calcium ion buffering
GO:0099510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium ion binding involved in regulation of cytosolic calcium ion concentration
RHEA:41865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-[ACP] + H(+) + NADPH => decanoyl-[ACP] + NADP(+)
REACT:R-RNO-8864105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 binds ERBB2:EGFR heterodimers (Rattus norvegicus)
REACT:R-CFA-174657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Canis familiaris)
REACT:R-DRE-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Danio rerio)
RHEA:33274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)
RHEA:25692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+)
REACT:R-DDI-9027628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises EPA to 5-HEPE (Dictyostelium discoideum)
REACT:R-MMU-8865637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFSD2A transports LPC from extracellular region to plasma membrane (Mus musculus)
REACT:R-SCE-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Saccharomyces cerevisiae)
REACT:R-HSA-8848178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 stimulates SOCS3 expression (Homo sapiens)
RHEA:55416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biochanin A + UDP-alpha-D-glucose = biochanin A 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-CFA-9759154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM21 ubiquitinates SQSTM1 (Canis familiaris)
RHEA:31488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose => H(+) + soyasaponin III + UDP
REACT:R-DRE-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Danio rerio)
RHEA:40888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + octadecanoate + sn-glycerol 3-phosphocholine
REACT:R-CEL-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Caenorhabditis elegans)
RHEA:69446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:70937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(out) => L-lysine(in)
REACT:R-DME-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Drosophila melanogaster)
REACT:R-HSA-5659922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SI does not hydrolyze Mal (Homo sapiens)
REACT:R-RNO-2028651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Rattus norvegicus)
RHEA:55481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:30477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + H(+) + oroxylin A => H2O + oroxylin A 7-O-beta-D-glucuronate
RHEA:63555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin-(1-7) + H2O <=> angiotensin-(1-5) + L-histidyl-L-proline
GO:0102252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellulose 1,4-beta-cellobiosidase activity (reducing end)
REACT:R-XTR-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Xenopus tropicalis)
RHEA:21599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH
RHEA:10854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sophoraflavanone G => dimethylallyl diphosphate + leachianone G
REACT:R-BTA-5610760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by ITCH (Bos taurus)
RHEA:13457	skos:altLabel	"BCOAD"
RHEA:13457	skos:altLabel	"branched-chain 2-oxo acid dehydrogenase"
RHEA:13457	skos:altLabel	"2-oxoisocaproate dehydrogenase"
RHEA:13457	skos:altLabel	"branched-chain alpha-keto acid dehydrogenase"
RHEA:13457	skos:altLabel	"alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase"
RHEA:13457	skos:altLabel	"dehydrogenase, 2-oxoisovalerate (lipoate)"
RHEA:13457	skos:altLabel	"BCKDH"
RHEA:13457	skos:altLabel	"branched chain keto acid dehydrogenase"
RHEA:13457	skos:altLabel	"alpha-ketoisocaproate dehydrogenase"
RHEA:13457	skos:altLabel	"alpha-oxoisocaproate dehydrogenase"
RHEA:13457	skos:altLabel	"alpha-keto-alpha-methylvalerate dehydrogenase"
RHEA:13457	skos:altLabel	"2-oxoisovalerate (lipoate) dehydrogenase"
RHEA:13457	skos:altLabel	"branched-chain alpha-oxo acid dehydrogenase"
RHEA:13457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)"
RHEA:13457	skos:prefLabel	"3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)"
RHEA:13457	skos:altLabel	"alpha-ketoisovalerate dehydrogenase"
RHEA:13457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2
RHEA:13457	skos:altLabel	"branched-chain (-2-oxoacid) dehydrogenase (BCD)"
RHEA:13457	skos:altLabel	"alpha-ketoisocaproic dehydrogenase"
RHEA:13457	skos:altLabel	"branched-chain 2-keto acid dehydrogenase"
RHEA:13457	skos:altLabel	"3-methyl-2-oxobutanoate dehydrogenase (lipoamide)"
RHEA:13457	skos:altLabel	"branched-chain keto acid dehydrogenase"
RHEA:13457	skos:altLabel	"branched-chain ketoacid dehydrogenase"
RHEA:50281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate
RHEA:39686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)
RHEA:68449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-lycopene + O2 => (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal
RHEA:60278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine
GO:0005031	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NGF/TNF (6 C-domain) receptor activity
GO:0005031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tumor necrosis factor-activated receptor activity
GO:0005031	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tumor necrosis factor receptor activity, type I
GO:0005031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tumor necrosis factor receptor activity
GO:0005031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF receptor activity
GO:0005031	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TNF receptor activity, type II
GO:0005031	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TNF receptor activity, type I
GO:0005031	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tumor necrosis factor receptor activity, type II
REACT:R-MMU-375330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 45/Connexin 36 mediated neuronal gap junction communication (Mus musculus)
RHEA:57052	skos:prefLabel	"3-oxoisoapionate decarboxylase"
RHEA:57052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate + H(+) = CO2 + L-erythrulose
RHEA:57052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxoisoapionate decarboxylase"
EC:2.4.1.255	skos:prefLabel	"protein O-GlcNAc transferase"
EC:2.4.1.255	skos:altLabel	"O-linked N-acetylglucosaminyltransferase"
EC:2.4.1.255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein O-GlcNAc transferase"
EC:2.4.1.255	skos:altLabel	"OGTase"
RHEA:16248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DDI-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
REACT:R-SSC-9626848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Sus scrofa)
REACT:R-MMU-5624127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome target cargo to the primary cilium (Mus musculus)
REACT:R-GGA-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Gallus gallus)
REACT:R-DRE-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Danio rerio)
RHEA:15132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic CMP + H2O <=> CMP + H(+)
RHEA:33521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine
REACT:R-HSA-2466710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs (Homo sapiens)
RHEA:46953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-XTR-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Xenopus tropicalis)
GO:0002058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil binding
REACT:R-HSA-71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)
REACT:R-BTA-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Bos taurus)
RHEA:56596	skos:altLabel	"3,6-DKCMO"
RHEA:56596	skos:altLabel	"3,6-diketocamphane lactonizing enzyme"
RHEA:56596	skos:prefLabel	"3,6-diketocamphane 1,2-monooxygenase"
RHEA:56596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,6-diketocamphane 1,2-monooxygenase"
RHEA:56596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-bornane-2,5-dione + FMNH2 + O2 = (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O
REACT:R-DME-5610754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Drosophila melanogaster)
REACT:R-XTR-8940074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NMN (Xenopus tropicalis)
REACT:R-CFA-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Canis familiaris)
RHEA:51326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2
RHEA:14878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate => ADP + L-glutamyl 5-phosphate
REACT:R-XTR-1676204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Xenopus tropicalis)
REACT:R-MMU-622325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)
REACT:R-GGA-8937744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-7Y-RUNX1 (Gallus gallus)
REACT:R-DRE-8878143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SMAD3 and SMAD4 (Danio rerio)
RHEA:40864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + heptadecanoyl-CoA => FADH2 + trans-2-heptadecenoyl-CoA
RHEA:34564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-abequose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH
REACT:R-CEL-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Caenorhabditis elegans)
RHEA:31823	skos:prefLabel	"cubebol synthase"
RHEA:31823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = cubebol + diphosphate
RHEA:31823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cubebol synthase"
REACT:R-SSC-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Sus scrofa)
RHEA:29220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + sn-glycerol 3-phosphate => a menaquinol + dihydroxyacetone phosphate
GO:0062188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anandamide 11,12 epoxidase activity
GO:0062188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
RHEA:60952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-5-hydroxyferulate + S-adenosyl-L-methionine = (E)-sinapate + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-2454081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5 oxidises 11cROL to 11cRAL (Danio rerio)
REACT:R-DME-6799203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Drosophila melanogaster)
RHEA:69038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5beta-androstane-17-one + NADP(+) => 5beta-androstane-3,17-dione + H(+) + NADPH
REACT:R-SSC-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Sus scrofa)
REACT:R-CEL-173705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b binds C6 (Caenorhabditis elegans)
REACT:R-RNO-5669250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates FLNA (Rattus norvegicus)
REACT:R-HSA-9017441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG gene expression is inhibited by MECP2 (Homo sapiens)
REACT:R-XTR-165026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Xenopus tropicalis)
RHEA:41327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate
RHEA:40730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid <=> a 1-acylglycerone 3-phosphate + hexadecanoate
RHEA:58007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside F2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP
REACT:R-CEL-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Caenorhabditis elegans)
REACT:R-DME-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
RHEA:12053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + trichodiene
REACT:R-RNO-8851352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR8 binds CCL1 (Rattus norvegicus)
REACT:R-DRE-9707516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM dissociates from MetHb (Danio rerio)
RHEA:72614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-lysine(out) <=> H(+)(in) + L-alanyl-L-lysine(in)
RHEA:64446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine
EC:3.4.23.45	skos:altLabel	"beta-secretase"
EC:3.4.23.45	skos:altLabel	"membrane-associated aspartic protease 1"
EC:3.4.23.45	skos:altLabel	"Down region aspartic protease"
EC:3.4.23.45	skos:altLabel	"beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2"
EC:3.4.23.45	skos:altLabel	"BACE2"
EC:3.4.23.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"memapsin 1"
EC:3.4.23.45	skos:altLabel	"beta-site APP-cleaving enzyme 2"
EC:3.4.23.45	skos:altLabel	"ASP1"
EC:3.4.23.45	skos:prefLabel	"memapsin 1"
REACT:R-SSC-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Sus scrofa)
REACT:R-BTA-8944240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type III (Bos taurus)
RHEA:58781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine => a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine
REACT:R-XTR-110360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to the AP site (Xenopus tropicalis)
RHEA:22253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside Gb4Cer (d18:1(4E)) + H(+) + UDP
GO:0043828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate
GO:0043828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA 2-selenouridine synthase"
GO:0043828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA 2-selenouridine synthase activity
GO:0043828	skos:prefLabel	"tRNA 2-selenouridine synthase"
REACT:R-CEL-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Caenorhabditis elegans)
GO:0052675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methylbutanol:NADP+ oxidoreductase activity
GO:0052675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol:NADP oxidoreductase activity
GO:0052675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanal reductase (NADP) activity
GO:0052675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoamyl alcohol oxidase (NADP) activity
GO:0052675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutyraldehyde reductase (NADP) activity
REACT:R-MMU-9018573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds activated EGFR (Mus musculus)
REACT:R-XTR-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Xenopus tropicalis)
REACT:R-BTA-5607741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p52:RELB translocates from cytosol to nucleus (Bos taurus)
RHEA:13281	skos:prefLabel	"3-hydroxy-2-methylbutyryl-CoA dehydrogenase"
RHEA:13281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH
RHEA:13281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-2-methylbutyryl-CoA dehydrogenase"
RHEA:13281	skos:altLabel	"2-methyl-3-hydroxybutyryl-CoA dehydrogenase"
REACT:R-XTR-391936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP1 receptor can bind PGE2 (Xenopus tropicalis)
RHEA:37754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-trans-aconitate <=> 2-methyl-cis-aconitate
REACT:R-SPO-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Schizosaccharomyces pombe)
RHEA:30280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Canis familiaris)
RHEA:20548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-kynurenine + NADPH + O2 <=> 3-hydroxy-L-kynurenine + H2O + NADP(+)
REACT:R-DME-374663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Ezrin (Drosophila melanogaster)
REACT:R-RNO-2161779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LXA4 is oxidised to 15k-LXA4 by HPGD (Rattus norvegicus)
REACT:R-CEL-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Caenorhabditis elegans)
RHEA:18344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,4-lactone + H2O <=> D-xylonate + H(+)
REACT:R-SCE-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
REACT:R-BTA-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Bos taurus)
REACT:R-DME-9619376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK1 binds calmodulin (Drosophila melanogaster)
REACT:R-SPO-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Schizosaccharomyces pombe)
REACT:R-SSC-193696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Sus scrofa)
RHEA:39264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH => (13Z)-docosenoyl-CoA + NADP(+)
RHEA:10538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O
RHEA:23757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinono-1,4-lactone + O2 => dehydro-D-arabinono-1,4-lactone + H(+) + H2O2
GO:0051430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 corticotropin releasing factor receptor binding
GO:0051430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 corticotropin-releasing factor receptor binding
GO:0051430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin-releasing hormone receptor 1 binding
GO:0051430	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 corticotropin releasing factor receptor ligand
GO:0051430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR1 binding
RHEA:11151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(2+) + 4 H(+) + O2 <=> 4 Fe(3+) + 2 H2O
REACT:R-HSA-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Homo sapiens)
REACT:R-XTR-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)
REACT:R-SSC-8849102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRMS phosphorylates PTK6 (Sus scrofa)
REACT:R-DRE-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Danio rerio)
RHEA:66957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
RHEA:72795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin-bisglucuronoside(out) = bilirubin-bisglucuronoside(in)
REACT:R-BTA-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Bos taurus)
RHEA:37043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-glutamate(out) = ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate
REACT:R-BTA-8875558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 binds CRK,CRKL (Bos taurus)
RHEA:23013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + S-adenosyl-L-methionine => a fatty acid methyl ester + S-adenosyl-L-homocysteine
RHEA:32217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADHX => (6R)-NADHX
REACT:R-BTA-202722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD48 binds CD244 (Bos taurus)
REACT:R-RNO-5684862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Rattus norvegicus)
RHEA:56787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O <=> (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate
RHEA:45689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)
RHEA:11422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + senecionine N-oxide => NADPH + O2 + senecionine
REACT:R-GGA-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Gallus gallus)
REACT:R-XTR-109759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Xenopus tropicalis)
REACT:R-SSC-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Sus scrofa)
RHEA:48457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate
GO:0047455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16-alpha-hydroxyprogesterone dehydroxylase activity
GO:0047455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-alpha-hydroxyprogesterone dehydratase activity
GO:0047455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16alpha-hydroxyprogesterone dehydroxylase activity
GO:0047455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyprogesterone dehydroxylase activity
GO:0047455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16alpha-hydroxyprogesterone hydro-lyase activity
GO:0047455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)
GO:0047455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16alpha-dehydroxylase activity
GO:0047455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16-dehydroprogesterone hydratase activity
GO:0047455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16alpha-hydroxyprogesterone dehydratase activity
GO:0047455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16-alpha-dehydroxylase activity
REACT:R-SSC-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Sus scrofa)
REACT:R-DME-380574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine synaptic vesicle docking and priming (Drosophila melanogaster)
REACT:R-RNO-5336182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37 binds prosaptide (Rattus norvegicus)
RHEA:42938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(32) in tRNA
RHEA:49108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine
RHEA:22754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + barbiturate + H(+) => A + H2O + uracil
REACT:R-HSA-2186747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)
REACT:R-SPO-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Schizosaccharomyces pombe)
REACT:R-HSA-74948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates p-RHO to RHO (Homo sapiens)
RHEA:58508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O = (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
GO:0047310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine--scyllo-inosose aminotransferase activity
GO:0047310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine-scyllo-inositol transaminase activity
GO:0047310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine scyllo-inosose aminotransferase activity
GO:0047310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine-scyllo-inosose transaminase activity
GO:0047310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine-keto-scyllo-inositol aminotransferase activity
GO:0047310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity
GO:0047310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine--scyllo-inosose transaminase activity
GO:0047310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine-scyllo-inosose aminotransferase activity
GO:0047310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine-scyllo-inosose transaminase activity
REACT:R-DME-6799495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYCTK phosphorylates DGA to 3PDGA (Drosophila melanogaster)
RHEA:53023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + an L-alpha-amino acid + H2O <=> a 2-oxocarboxylate + a plastoquinol + NH4(+)
REACT:R-SPO-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Schizosaccharomyces pombe)
REACT:R-MMU-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Mus musculus)
REACT:R-RNO-6805470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates TP53 (Rattus norvegicus)
RHEA:25124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate <=> H(+) + H2O + L-1-piperideine-6-carboxylate
RHEA:38500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O => a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)
REACT:R-DME-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Drosophila melanogaster)
REACT:R-XTR-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Xenopus tropicalis)
REACT:R-GGA-9008577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37:IL18R1 binds SIGIRR (Gallus gallus)
RHEA:40536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]
GO:0086077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in atrioventricular node cell-bundle of His cell electrical coupling
GO:0086077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
EC:1.3.1.113	skos:prefLabel	"(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase"
EC:1.3.1.113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase"
RHEA:60355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-3-hydroxy-4(1H)-quinolone + O2 <=> CO + H(+) + N-octanoylanthranilate
RHEA:45187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O
REACT:R-PFA-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Plasmodium falciparum)
REACT:R-SPO-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)
REACT:R-DRE-449976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Danio rerio)
RHEA:40791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexacosanoyl-CoA = CoA + H(+) + hexacosanoate
REACT:R-DRE-5205672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncleaved Pink1 accumulates in damaged mitochondria (Danio rerio)
REACT:R-CFA-1306969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
REACT:R-MMU-9796368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 binds STUB1 (Mus musculus)
REACT:R-BTA-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Bos taurus)
REACT:R-XTR-6789072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP1 binds bacterial peptidoglycan (Xenopus tropicalis)
RHEA:46311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Schizosaccharomyces pombe)
RHEA:44888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)
RHEA:43154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine => adenosine(58) in tRNA + S-adenosyl-L-methionine
REACT:R-XTR-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Xenopus tropicalis)
RHEA:48473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1a + H2O => ganglioside GD1a + N-acetylneuraminate
RHEA:48883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + CO + H2O <=> a quinol + CO2
REACT:R-XTR-77342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Xenopus tropicalis)
RHEA:62921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol => 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal
REACT:R-SPO-9011543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCA binds PDK2 (Schizosaccharomyces pombe)
REACT:R-RNO-2002428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen N-propeptides (Rattus norvegicus)
RHEA:12446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenal + H(+) + NADPH => hexadecanal + NADP(+)
GO:0008871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside 2''-nucleotidyltransferase activity
GO:0008871	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentamicin 2''-nucleotidyltransferase activity
GO:0008871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2''-aminoglycoside nucleotidyltransferase activity
GO:0008871	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentamycin 2''-nucleotidyltransferase activity
GO:0008871	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentamicin 2''- adenylyltransferase activity
GO:0008871	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NTP:gentamicin 2''-nucleotidyltransferase activity
REACT:R-GGA-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Gallus gallus)
GO:0044101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	R-citramalyl-CoA lyase activity
GO:0044101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-citramalyl-CoA lyase activity
GO:0044101	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ccl
REACT:R-CFA-5696564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP25 deubiquitinates DDX58 (Canis familiaris)
REACT:R-HSA-9630045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective NTHL1 truncation mutants do not bind dihydrouracil (DHU) (Homo sapiens)
REACT:R-HSA-5696491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNTF binds CNTFR complex (Homo sapiens)
REACT:R-DME-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)
RHEA:58657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine
GO:0099579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
GO:0099579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
REACT:R-MMU-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Mus musculus)
REACT:R-DME-9634169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 and NDC1 bind the Nup93 complex (Drosophila melanogaster)
RHEA:68525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => beta-bisabolene + diphosphate
RHEA:60175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate <=> (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA
RHEA:18372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H2O2
REACT:R-SPO-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Schizosaccharomyces pombe)
RHEA:52026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18S-resolvin E2 + A + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2
REACT:R-HSA-110210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG glycosylase mediated recognition and binding of an ethenocytosine (Homo sapiens)
RHEA:53872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + D-ribose 5-phosphate + H(+) = CDP-D-ribose + diphosphate
REACT:R-DME-9648268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A antagonists (Drosophila melanogaster)
REACT:R-SCE-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Saccharomyces cerevisiae)
REACT:R-DRE-3249371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylates STAT6 at Ser407 (Danio rerio)
REACT:R-SSC-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Sus scrofa)
RHEA:45090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ganglioside GM2 synthase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GM2/GD2-synthase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GM2 synthase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4N-aetylgalactosaminyltransferase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GalNAc-T activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ganglioside GM3 acetylgalactosaminyltransferase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asialo-GM2 synthase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity
GO:0003947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity
REACT:R-XTR-266315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + spherical HDL <=> LCAT:spherical HDL complex (Xenopus tropicalis)
REACT:R-XTR-450971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Xenopus tropicalis)
RHEA:11455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]
RHEA:69095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + pentanal <=> 2 H(+) + NADH + pentanoate
RHEA:28577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + sulfate(in) <=> H(+)(out) + sulfate(out)
RHEA:14015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate => 3'-phosphoadenylyl sulfate + taurolithocholate
RHEA:40405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP
RHEA:55200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine
RHEA:55200	skos:prefLabel	"5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase"
RHEA:55200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase"
REACT:R-SSC-975103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Sus scrofa)
RHEA:54421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-AMP + H2O => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)
REACT:R-MMU-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Mus musculus)
REACT:R-CFA-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Canis familiaris)
REACT:R-GGA-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Gallus gallus)
RHEA:28891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + putrescine(in) = H(+)(out) + putrescine(out)
REACT:R-HSA-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Homo sapiens)
RHEA:14337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylgalactosamine-4-sulfate sulfotransferase"
RHEA:14337	skos:prefLabel	"UDP-N-acetylgalactosamine-4-sulfate sulfotransferase"
RHEA:14337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate = adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate
RHEA:16866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + propanoyl-CoA => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA
REACT:R-GGA-9006873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT binding (Gallus gallus)
REACT:R-CFA-8874208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Canis familiaris)
RHEA:52734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+) => 3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate
REACT:R-DME-1253343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds ERBB4s80 (Drosophila melanogaster)
REACT:R-RNO-421007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of Ca impermeable AMPA receptors (Rattus norvegicus)
REACT:R-DME-432535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIM is phosphorylated by CK2 (Drosophila melanogaster)
REACT:R-HSA-5687123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S115 MAPKAPK5 translocates to the cytosol (Homo sapiens)
RHEA:20748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate
RHEA:20748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deacetoxycephalosporin-C synthase"
RHEA:20748	skos:altLabel	"DAOC synthase"
RHEA:20748	skos:altLabel	"penicillin N expandase"
RHEA:20748	skos:altLabel	"DAOCS"
RHEA:20748	skos:prefLabel	"deacetoxycephalosporin-C synthase"
REACT:R-GGA-5684250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Gallus gallus)
REACT:R-DRE-417908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY1 binds ADP (Danio rerio)
RHEA:72653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+) => 1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2
REACT:R-CFA-5250938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Canis familiaris)
REACT:R-DRE-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Danio rerio)
REACT:R-HSA-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
RHEA:61350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + estrone 3-sulfate(out) + H(+) + phosphate => ATP + estrone 3-sulfate(in) + H2O
REACT:R-BTA-417890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y5 receptor can bind to LPA (Bos taurus)
RHEA:21493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + H(+) => catechol + CO2
REACT:R-CFA-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Canis familiaris)
RHEA:50890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + phosphate => an N-acylsphingoid base 1-phosphate + H2O
REACT:R-PFA-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)
REACT:R-DME-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)
REACT:R-RNO-141341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMOX-3 oxidises SPN to SPM (Rattus norvegicus)
RHEA:31242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + uroporphyrinogen I <=> 4 CO2 + coproporphyrinogen I
REACT:R-HSA-5684275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
RHEA:14667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + xanthine => guanine + H(+) + H2O
REACT:R-XTR-192335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Xenopus tropicalis)
GO:0042929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferrichrome transporter activity
GO:0042929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferrichrome transmembrane transporter activity
REACT:R-DDI-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Dictyostelium discoideum)
RHEA:29000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + homoserine lactone(in) => H(+)(in) + homoserine lactone(out)
REACT:R-MMU-5626223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)
REACT:R-CFA-9011949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Canis familiaris)
REACT:R-XTR-622310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD1 oligomerizes (Xenopus tropicalis)
REACT:R-BTA-426223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cation influx mediated by TRPC3/6/7 (Bos taurus)
RHEA:68873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + ATP + H(+) + NADPH => (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)
RHEA:62706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-didehydrophenylalanine + glycine => glycyldehydrophenylalanine + H2O
REACT:R-XTR-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Xenopus tropicalis)
REACT:R-MMU-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Mus musculus)
RHEA:19972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylamine + O2 <=> H(+) + H2O + nitrite
RHEA:67626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine
REACT:R-XTR-74993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Xenopus tropicalis)
REACT:R-XTR-5687183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKDC phosphorylates DCLRE1C at DNA DSBs (Xenopus tropicalis)
RHEA:23619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-alpha-santonin + NADP(+) <=> alpha-santonin + H(+) + NADPH
RHEA:59547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose + O2 <=> H2O2 + N,N'-diacetylchitobiono-1,5-lactone
REACT:R-BTA-141351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAOX:FAD oxidises NASPN to SPM (Bos taurus)
RHEA:57736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-3,4-didehydro-13,14-dihydroretinol = AH2 + all-trans-3,4-didehydroretinol
REACT:R-GGA-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Gallus gallus)
REACT:R-MMU-2395257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-hydroxylysino-norleucine cross-links (Mus musculus)
RHEA:20485	skos:altLabel	"(S)-scoulerine oxidase (methylenedioxy-bridge-forming)"
RHEA:20485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:20485	skos:prefLabel	"(S)-cheilanthifoline synthase"
RHEA:20485	skos:altLabel	"CYP719A14"
RHEA:20485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-cheilanthifoline synthase"
REACT:R-RNO-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)
REACT:R-CFA-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)
RHEA:20554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-methylmalonyl-CoA => (S)-methylmalonyl-CoA
GO:0004676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3-phosphate protein kinase activity
GO:0004676	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDK activity
GO:0004676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoinositide-dependent protein kinase activity
GO:0004676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 activates PRKCZ (Homo sapiens)
REACT:R-MMU-936951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to activated TLR4 complex (Mus musculus)
RHEA:18387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + 2 AMP + 4 H(+) + 4 phosphate => acetone + 2 ATP + 3 H2O + hydrogencarbonate
EC:3.2.1.211	skos:altLabel	"alpha-L-fucosidase"
EC:3.2.1.211	skos:prefLabel	"endo-(1->3)-fucoidanase"
EC:3.2.1.211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endo-(1->3)-fucoidanase"
EC:3.2.1.211	skos:altLabel	"poly(1,3-alpha-L-fucoside-2/4-sulfate) glycanohydrolase"
REACT:R-HSA-9007465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UXT gene expression is repressed by the PRC1L4 complex (Homo sapiens)
REACT:R-DRE-209792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylation of serotonin (Danio rerio)
REACT:R-XTR-8866268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADBRK1,2 phosphorylate AVPR2 (Xenopus tropicalis)
REACT:R-BTA-6800315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 binds MST1R (Bos taurus)
RHEA:40659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-HSA-1655453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTAUDH oxidises HTAU to TAU (Homo sapiens)
RHEA:11113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isochorismate => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate
REACT:R-RNO-177923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)
RHEA:55688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)
REACT:R-HSA-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Homo sapiens)
REACT:R-HSA-9604969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds PTPN11 (Homo sapiens)
RHEA:12193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate
RHEA:56937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-androst-5-en-3-one => testosterone
REACT:R-BTA-9678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 binds S1PR1 agonists (Bos taurus)
RHEA:12479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-glutamate <=> formate + L-glutamate
REACT:R-GGA-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
REACT:R-DRE-5654614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)
REACT:R-GGA-72143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lariat Formation and 5'-Splice Site Cleavage (Gallus gallus)
RHEA:50359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-methylpretetramide + NADPH + O2 <=> 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)
REACT:R-BTA-5654641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)
REACT:R-HSA-3927959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of CREBBP with SUMO1 (Homo sapiens)
RHEA:34350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + NAD(+) <=> (2E)-geranial + H(+) + NADH
REACT:R-MMU-1679589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal full-length TLR9 (Mus musculus)
GO:0043864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Tms2
GO:0043864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole acetamide hydrolase activity
GO:0043864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IaaH
GO:0043864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetamide hydrolase activity
GO:0043864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoleacetamide hydrolase activity
GO:0043864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAH
RHEA:31780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an all-trans-retinyl ester + H2O => 13-cis-retinol + a fatty acid + H(+)
REACT:R-CFA-997311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of TYK2 by PTP1B (Canis familiaris)
RHEA:25696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate
REACT:R-SCE-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Saccharomyces cerevisiae)
REACT:R-DRE-449115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Danio rerio)
REACT:R-RNO-5138433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Rattus norvegicus)
RHEA:70570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-SCE-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Saccharomyces cerevisiae)
REACT:R-DRE-9691621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5 binds C5 inhibitors (Danio rerio)
REACT:R-SSC-9748996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers cleave AZA to 6MP (Sus scrofa)
REACT:R-RNO-166538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The bound receptor dimerizes (Rattus norvegicus)
RHEA:23451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP <=> CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate
GO:0140608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type endopeptidase activator activity
GO:0140608	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	caspase activator activator activity
RHEA:11635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-selenocysteine <=> A + H(+) + hydrogenselenide + L-alanine
REACT:R-DME-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)
RHEA:65374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + globoside MSGG + H(+) => CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer
REACT:R-HSA-9619449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)
RHEA:12523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa <=> (E)-caffeate + NH4(+)
REACT:R-SCE-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)
GO:0015052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta3 adrenoceptor
GO:0015052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta3-adrenergic receptor activity
RHEA:64701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH
RHEA:66724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + L-phenylalanine = H2O + N-[(S)-lactoyl]-L-phenylalanine
REACT:R-HSA-8961920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the CDK1 gene promoter (Homo sapiens)
REACT:R-CFA-5686304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Canis familiaris)
REACT:R-XTR-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Xenopus tropicalis)
RHEA:51035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloroindole-3-pyruvate imine dimer <=> dichlorochromopyrrolate + H(+) + NH4(+)
REACT:R-HSA-9665709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)
GO:0004699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-independent protein kinase C activity
GO:0004699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-independent PKC activity
GO:0004699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta phosphorylates CARD9 (Homo sapiens)
GO:0004699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	novel protein kinase C activity
GO:0140443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrion-plasma membrane adaptor activity
GO:0140443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrion plasma membrane adaptor activity
GO:0140443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasma membrane-mitochondrion adaptor activity
GO:0140443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrion plasma membrane tether activity
GO:0140443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasma membrane-mitochondrion tether activity
REACT:R-MMU-8853762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET dimerizes (Mus musculus)
RHEA:66065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxohexanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate
REACT:R-SSC-1295632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA2A dephosphorylates SPRY2 (Sus scrofa)
REACT:R-RNO-177107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion and activation of the latent large complex of TGF-beta-1 (Rattus norvegicus)
REACT:R-MMU-375140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds promyogenic cadherins (Mus musculus)
RHEA:20098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate => 2-dehydro-3-deoxy-D-gluconate + H2O
RHEA:58370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z)-nona-2,6-dienal + H(+) + NADPH => (2E,6Z)-nona-2,6-dien-1-ol + NADP(+)
GO:0045509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-27 receptor activity
GO:0045509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-27R
GO:0045509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-27 receptor activity
REACT:R-CEL-176664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + PAPS => estrone 3-sulfate + PAP (Caenorhabditis elegans)
GO:0008939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GO:0008939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N1-alpha-phosphoribosyltransferase activity
GO:0008939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobT
GO:0008939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(1)-alpha-phosphoribosyltransferase activity
GO:0008939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity
GO:0008939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity
GO:0008939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GO:0008939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity
GO:0008939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity
REACT:R-HSA-1592229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM translocates from the cytosol to the mitochondrial matrix (Homo sapiens)
REACT:R-SSC-112042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid binds MOR (Sus scrofa)
REACT:R-CFA-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Canis familiaris)
RHEA:17236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fucose <=> L-fuculose
GO:0046408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide-a:phytyl-diphosphate phytyltransferase activity
GO:0046408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll synthetase activity
GO:0046408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll synthase activity
REACT:R-XTR-8875659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Xenopus tropicalis)
GO:0034819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-HSA hydroxylase activity
RHEA:65193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + 2 O2 + preaustinoid A => berkeleytrione + 2 CO2 + H2O + 2 succinate
RHEA:64465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[protein] + 2 O2 => H(+) + H2O2 + L-topaquinyl-[protein]
REACT:R-DME-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
RHEA:55836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP
REACT:R-HSA-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Homo sapiens)
RHEA:31011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = camelliol C
RHEA:31011	skos:prefLabel	"camelliol C synthase"
RHEA:31011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"camelliol C synthase"
GO:0003681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bent DNA binding
REACT:R-RNO-375330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 45/Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)
REACT:R-XTR-5661240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCXR tetramer reduces L-xylulose to xylitol (Xenopus tropicalis)
REACT:R-XTR-350058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL NCOR corepressor complex (Xenopus tropicalis)
REACT:R-MMU-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Mus musculus)
GO:0016748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyltransferase activity
REACT:R-HSA-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Homo sapiens)
RHEA:64153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)
REACT:R-RNO-629588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Rattus norvegicus)
REACT:R-MMU-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Mus musculus)
REACT:R-HSA-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Homo sapiens)
REACT:R-GGA-9696266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds effectors (Gallus gallus)
REACT:R-SSC-75244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL binds FAS Receptor (Sus scrofa)
REACT:R-CEL-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Caenorhabditis elegans)
GO:0097200	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	effector caspase activity
GO:0097200	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	executioner caspase activity
GO:0097200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type endopeptidase activity involved in execution phase of apoptosis
REACT:R-CEL-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Caenorhabditis elegans)
REACT:R-CFA-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Canis familiaris)
RHEA:15605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine-sulfate ammonia-lyase"
RHEA:15605	skos:prefLabel	"serine-sulfate ammonia-lyase"
RHEA:15605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine O-sulfate = H(+) + NH4(+) + pyruvate + sulfate
RHEA:37689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol
RHEA:10901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic L-alpha-amino acid + glyoxylate => an aromatic oxo-acid + glycine
REACT:R-HSA-9017855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD3 binds to TACC3 (Homo sapiens)
REACT:R-BTA-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Bos taurus)
REACT:R-HSA-434836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk/Lck phosphorylate LAT (Homo sapiens)
REACT:R-BTA-5654729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Bos taurus)
RHEA:52565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-L-erythronate => 3-dehydro-L-erythronate
EC:3.2.1.163	skos:prefLabel	"1,6-alpha-D-mannosidase"
EC:3.2.1.163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,6-alpha-D-mannosidase"
REACT:R-CFA-1234164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)
REACT:R-MMU-266012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTD4 is converted to LTE4 by DPEP1/2 (Mus musculus)
RHEA:64658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + H(+) + NADPH => (E)-sinapaldehyde + CoA + NADP(+)
RHEA:43026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + a thiol => an S-substituted L-cysteine
REACT:R-BTA-1793209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses Chondroitin chains (Bos taurus)
RHEA:34548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(II)yrinate + H2O + L-glutamine => ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate
RHEA:68613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin E1 => NADP(+) + prostaglandin F1
REACT:R-DME-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Drosophila melanogaster)
REACT:R-CEL-2396399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillins bind BMPs (Caenorhabditis elegans)
REACT:R-DRE-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Danio rerio)
RHEA:47721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + isoguanine => NH4(+) + xanthine
GO:0010435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPC-8:0 CoA ligase activity
GO:0010435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity
GO:0010435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity
GO:0010435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase activity
REACT:R-RNO-9025995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Rattus norvegicus)
REACT:R-HSA-1606564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Homo sapiens)
RHEA:46929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol
REACT:R-GGA-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)
REACT:R-CFA-177939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
REACT:R-SPO-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Schizosaccharomyces pombe)
REACT:R-MMU-71050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of the FASL:FAS receptor complex (Mus musculus)
REACT:R-DME-432436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes (Drosophila melanogaster)
REACT:R-HSA-180603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteosome-mediated degradation of APOBEC3G (Homo sapiens)
RHEA:18861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine = a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine
RHEA:18861	skos:prefLabel	"5-hydroxyfuranocoumarin 5-O-methyltransferase"
RHEA:18861	skos:altLabel	"bergaptol O-methyltransferase"
RHEA:18861	skos:altLabel	"furanocoumarin 5-O-methyltransferase"
RHEA:18861	skos:altLabel	"furanocoumarin 5-methyltransferase"
RHEA:18861	skos:altLabel	"BMT"
RHEA:18861	skos:altLabel	"bergaptol 5-O-methyltransferase"
RHEA:18861	skos:altLabel	"bergaptol methyltransferase"
RHEA:18861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-hydroxyfuranocoumarin 5-O-methyltransferase"
REACT:R-SSC-451366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38MAPK by DSCAM (Sus scrofa)
RHEA:57525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O => a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)
REACT:R-GGA-5676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD74 binds MIF (Gallus gallus)
REACT:R-DRE-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Danio rerio)
RHEA:51915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate
RHEA:10887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,24(1)R)-fucosterol epoxide <=> acetaldehyde + desmosterol
REACT:R-SCE-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Saccharomyces cerevisiae)
REACT:R-HSA-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Homo sapiens)
REACT:R-GGA-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Gallus gallus)
REACT:R-PFA-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Plasmodium falciparum)
RHEA:53303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O <=> H(+) + N-carbamoyl-D-methionine
RHEA:69070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide => AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline
RHEA:50753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 naphthalene-1,2,4,8-tetrol + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O
REACT:R-CFA-419646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:Met (Canis familiaris)
REACT:R-SSC-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Sus scrofa)
GO:0031690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenergic receptor binding
GO:0031690	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	adrenergic receptor ligand
REACT:R-HSA-9021334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 binds HEY1 gene promoter (Homo sapiens)
REACT:R-CEL-173488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SMAD2/3:SMAD4 complex transfers to the nucleus (Caenorhabditis elegans)
REACT:R-HSA-5693566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 associates with H4K20Me2 at DNA DSBs (Homo sapiens)
REACT:R-HSA-1234173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
REACT:R-RNO-4719447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO1 (Rattus norvegicus)
REACT:R-DME-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Drosophila melanogaster)
RHEA:69549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-phospho-L-serine => CO2 + phosphoethanolamine
RHEA:21496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O = diphosphate + prenol
RHEA:21496	skos:prefLabel	"prenyl-diphosphatase"
RHEA:21496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prenyl-diphosphatase"
RHEA:21496	skos:altLabel	"prenyl-pyrophosphatase"
RHEA:49055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperlicin C + H(+) + NADH + O2 <=> asperlicin E + H2O + NAD(+)
REACT:R-SPO-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Schizosaccharomyces pombe)
RHEA:62840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-DRE-163217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Danio rerio)
RHEA:66979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose <=> alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)
GO:0004559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-mannopyranosidase activity
GO:0004559	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1,2-alpha-D-mannosidase activity
GO:0004559	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-nitrophenyl-alpha-mannosidase activity
GO:0004559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-mannosidase activity
GO:0004559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-mannoside mannohydrolase activity
GO:0004559	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1,2-alpha-mannosidase
GO:0004559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-mannosidase activity
GO:0004559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-alpha-mannosidase activity
REACT:R-XTR-8985929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Xenopus tropicalis)
REACT:R-SSC-5620914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF4:GTP binds VxPx-motifs of membrane proteins (Sus scrofa)
RHEA:62259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(out) + 2 hydrogencarbonate(out) <=> Cd(2+)(in) + 2 hydrogencarbonate(in)
RHEA:72435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-AMP + CoA = (E)-caffeoyl-CoA + AMP + H(+)
REACT:R-MMU-8874079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated MET (Mus musculus)
REACT:R-XTR-977317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Xenopus tropicalis)
REACT:R-DDI-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Dictyostelium discoideum)
RHEA:31359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + nitrilotriacetate + O2 = ammoniodiacetate + FMN + glyoxylate + H2O
RHEA:31359	skos:prefLabel	"nitrilotriacetate monooxygenase"
RHEA:31359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrilotriacetate monooxygenase"
RHEA:33923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)
REACT:R-BTA-5578965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A binds AGO2:miRNA (Bos taurus)
GO:0010176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate phytyltransferase activity
RHEA:61688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-threonine = AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]
RHEA:61688	skos:prefLabel	"L-threonine--[L-threonyl-carrier protein] ligase"
RHEA:61688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-threonine--[L-threonyl-carrier protein] ligase"
RHEA:17603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-ribulose 5-phosphate + H(+) => ATP + D-ribulose
RHEA:55964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)
GO:0015248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol transporter activity
GO:0015248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)
RHEA:30331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-carotene 3-hydroxylase"
RHEA:30331	skos:altLabel	"beta-carotene 3,3'-monooxygenase"
RHEA:30331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:30331	skos:prefLabel	"beta-carotene 3-hydroxylase"
RHEA:18879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine
RHEA:15951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxooctadecanoate + H(+) + NADH => (R)-2-hydroxyoctadecanoate + NAD(+)
REACT:R-HSA-8964311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):GTP binds SRC (Homo sapiens)
REACT:R-DDI-5658430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF1 is degraded by the proteasome (Dictyostelium discoideum)
REACT:R-MMU-1295632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA2A dephosphorylates SPRY2 (Mus musculus)
REACT:R-SSC-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Sus scrofa)
GO:0047913	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:gallate beta-D-glucosyltransferase activity
GO:0047913	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:gallate glucosyltransferase activity
GO:0047913	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:gallate beta-D-glucosyltransferase activity
GO:0047913	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-vanillate 1-glucosyltransferase activity
GO:0047913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gallate 1-beta-glucosyltransferase activity
GO:0047913	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:vanillate 1-O-glucosyltransferase activity
GO:0047913	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-vanillate 1-glucosyltransferase activity
GO:0047913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gallate 1-b-glucosyltransferase activity
RHEA:27494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + tricetin => 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine
RHEA:17061	skos:altLabel	"phenol o-hydroxylase"
RHEA:17061	skos:prefLabel	"phenol 2-monooxygenase (NADPH)"
RHEA:17061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenol 2-monooxygenase (NADPH)"
RHEA:17061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + phenol = catechol + H2O + NADP(+)
RHEA:17061	skos:altLabel	"phenol hydroxylase"
REACT:R-BTA-3214912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate MeK5-histone H3 (Bos taurus)
REACT:R-MMU-83788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to Type 2 promoter (Mus musculus)
REACT:R-SPO-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Schizosaccharomyces pombe)
REACT:R-CEL-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Caenorhabditis elegans)
RHEA:34467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valerena-4,7(11)-diene synthase"
RHEA:34467	skos:prefLabel	"valerena-4,7(11)-diene synthase"
RHEA:34467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + valerena-4,7(11)-diene
REACT:R-RNO-5423117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates MeK21-histone H4 (Rattus norvegicus)
REACT:R-DME-8854303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D11 binds RAB6 (Drosophila melanogaster)
EC:1.1.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol dehydrogenase (NADP(+))"
EC:1.1.1.2	skos:altLabel	"aldehyde reductase (NADPH)"
EC:1.1.1.2	skos:prefLabel	"alcohol dehydrogenase (NADP(+))"
RHEA:53534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate
REACT:R-RNO-5607753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD9 oligomerizes (Rattus norvegicus)
REACT:R-SSC-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Sus scrofa)
RHEA:36835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-BTA-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Bos taurus)
REACT:R-DME-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)
REACT:R-BTA-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Bos taurus)
RHEA:58894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9 => 3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9
EC:2.4.2.43	skos:altLabel	"4-amino-4-deoxy-L-arabinose lipid A transferase"
EC:2.4.2.43	skos:altLabel	"polymyxin resistance protein PmrK"
EC:2.4.2.43	skos:altLabel	"undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase"
EC:2.4.2.43	skos:altLabel	"undecaprenyl phosphate-alpha-L-Ara4N transferase"
EC:2.4.2.43	skos:prefLabel	"lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase"
EC:2.4.2.43	skos:altLabel	"lipid A 4-amino-4-deoxy-L-arabinosyltransferase"
EC:2.4.2.43	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase"
RHEA:42530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(955/2504/2580) in 23S rRNA => uridine(955/2504/2580) in 23S rRNA
REACT:R-SCE-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Saccharomyces cerevisiae)
REACT:R-SSC-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Sus scrofa)
REACT:R-PFA-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)
REACT:R-DRE-265428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with VCAM1 (Danio rerio)
RHEA:34690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + N-acyl-15-methylhexadecasphinganine + O2 <=> A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine
RHEA:58607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 H(+) + NADH + O2 <=> FADH2-C4alpha-hydroperoxide + NAD(+)
REACT:R-SSC-163217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Sus scrofa)
REACT:R-XTR-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Xenopus tropicalis)
RHEA:22727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sterol + UDP-alpha-D-glucose <=> a sterol 3-beta-D-glucoside + H(+) + UDP
RHEA:67424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid + H2O = a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)
REACT:R-MMU-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Mus musculus)
REACT:R-DRE-4641246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 autoubiquitinates to promote its internalization (Danio rerio)
RHEA:54914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinal + H(+) + NADPH => 11-cis-retinol + NADP(+)
GO:1903763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	innexin channel activity involved in cell communication by electrical coupling
GO:1903763	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	innexin involved in cell communication by electrical coupling
GO:1903763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in cell communication by electrical coupling
GO:1903763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	connexin involved in cell communication by electrical coupling
RHEA:68430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone => lutein + O2
REACT:R-HSA-9794008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC binds CFLAR (Homo sapiens)
REACT:R-CFA-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Canis familiaris)
RHEA:54172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) = 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-CFA-5654600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
RHEA:51400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + serotonin = CoA + H(+) + N-octadecanoyl-serotonin
RHEA:27576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-piperidine-3-carboxylate + NH4(+) => (3R)-piperidine-3-carboxamide + H2O
RHEA:71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(out) + H(+)(out) = acetoacetate(in) + H(+)(in)
RHEA:40714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate
REACT:R-XTR-9033491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Xenopus tropicalis)
EC:1.14.11.44	skos:altLabel	"2-oxoglutarate-dependent (R)-mecoprop dioxygenase"
EC:1.14.11.44	skos:prefLabel	"(R)-dichlorprop dioxygenase (2-oxoglutarate)"
EC:1.14.11.44	skos:altLabel	"(R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase"
EC:1.14.11.44	skos:altLabel	"(R)-mecoprop dioxygenase"
EC:1.14.11.44	skos:altLabel	"2-oxoglutarate-dependent (R)-dichlorprop dioxygenase"
EC:1.14.11.44	skos:altLabel	"alpha-ketoglutarate-dependent (R)-dichlorprop dioxygenase"
EC:1.14.11.44	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-dichlorprop dioxygenase (2-oxoglutarate)"
RHEA:11359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H(+) + NADH <=> AH2 + NAD(+)
REACT:R-GGA-422051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the signal peptide of Preproghrelin (Gallus gallus)
REACT:R-DRE-6804383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 methylates TP53 (Danio rerio)
REACT:R-BTA-994140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Bos taurus)
REACT:R-CEL-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Caenorhabditis elegans)
GO:0008309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded DNA exodeoxyribonuclease activity
GO:0008309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	double-stranded DNA specific exodeoxyribonuclease activity
RHEA:55981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated acyl-CoA + an acyl-CoA + H2O => an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)
REACT:R-XTR-193700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR ICD signals to NF-kB (Xenopus tropicalis)
REACT:R-HSA-158747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Homo sapiens)
REACT:R-GGA-187608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Gallus gallus)
REACT:R-DRE-265429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Danio rerio)
RHEA:14810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenol + S-adenosyl-L-methionine => anisole + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-8862152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Sus scrofa)
REACT:R-HSA-6805126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates TP53 (Homo sapiens)
REACT:R-SSC-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Sus scrofa)
RHEA:20199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparan-N-sulfate](n) => [heparosan-N-sulfate](n)
REACT:R-DDI-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Dictyostelium discoideum)
REACT:R-SSC-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Sus scrofa)
REACT:R-GGA-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)
REACT:R-SSC-8854738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR binds CSFR (Sus scrofa)
REACT:R-DRE-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Danio rerio)
RHEA:10001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pentanamide => NH4(+) + pentanoate
RHEA:49506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphinomethylisomalate => phosphinomethylmalate
RHEA:42980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine = 2-aminoprop-2-enoate + phenol
REACT:R-XTR-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Xenopus tropicalis)
REACT:R-BTA-8948231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)
RHEA:51198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + Na(+)(in) + serotonin(in) => chloride(out) + Na(+)(out) + serotonin(out)
REACT:R-HSA-6803871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates SFN expression (Homo sapiens)
RHEA:40441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose => 6-sulfo-beta-D-quinovose
RHEA:15693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 = (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O
RHEA:38826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
EC:7.5.2.-	skos:prefLabel	"Linked to the hydrolysis of a nucleoside triphosphate"
EC:7.5.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Linked to the hydrolysis of a nucleoside triphosphate"
RHEA:58644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate
RHEA:25505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => beta-phellandrene + diphosphate
REACT:R-MMU-114600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Mus musculus)
RHEA:10431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
GO:0046919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvyltransferase activity
REACT:R-DME-9024766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Drosophila melanogaster)
REACT:R-HSA-8939335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 polyubiquinates BCL10 (Homo sapiens)
REACT:R-RNO-5676607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF,sAPRIL binds TACI,BCMA (Rattus norvegicus)
REACT:R-DRE-163751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Danio rerio)
RHEA:61819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16,17-didehydropregnenolone + UDP-alpha-D-glucose <=> 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP
GO:0140575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane monodehydroascorbate reductase activity
GO:0140575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L-ascorbate(out) + monodehydro-L-ascorbate radical(in)
REACT:R-CEL-173720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7 translocates to the plasma membrane (Caenorhabditis elegans)
RHEA:28469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine(in) <=> pyridoxamine(out)
REACT:R-SSC-5223305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL, inhibiting it (Sus scrofa)
REACT:R-MMU-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Mus musculus)
REACT:R-BTA-2730844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GRB2:SOS complex with p-SHC1 (Bos taurus)
GO:0010314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-5-phosphate binding
RHEA:64385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine => alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine
REACT:R-MMU-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Mus musculus)
REACT:R-DRE-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Danio rerio)
RHEA:70434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + Li(+)(in) <=> 2 H(+)(in) + Li(+)(out)
REACT:R-DRE-451561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO binds polyubiquitinated IRAK1 (Danio rerio)
REACT:R-HSA-5655760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol (Homo sapiens)
REACT:R-RNO-196950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTRAP hydrolyzes FMN to RIB (Rattus norvegicus)
RHEA:53925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary amine + S-adenosyl-L-methionine => a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine
REACT:R-SPO-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Schizosaccharomyces pombe)
REACT:R-SCE-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Saccharomyces cerevisiae)
RHEA:29686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltohexaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltopentaose
REACT:R-RNO-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)
REACT:R-DRE-5687112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 is degraded by the 26S proteasome (Danio rerio)
RHEA:48103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
RHEA:38010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine
RHEA:43584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + iminoarginine = 5-guanidino-2-oxopentanoate + NH4(+)
RHEA:58296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine = 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine
REACT:R-HSA-188002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rab5-mediated recruitment of class III PI3K to TLR9 (Homo sapiens)
RHEA:17003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proclavaminate + urea => amidinoproclavaminate + H2O
RHEA:46735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,6)-dimethylheptanoyl-CoA <=> (2S,6)-dimethylheptanoyl-CoA
REACT:R-RNO-8952903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRHL2 hydrolyses poly(ADP-ribose) (Rattus norvegicus)
REACT:R-SSC-5218847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 binds NCK (Sus scrofa)
RHEA:54355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-HSA-2263496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective NAGLU does not hydrolyse Heparan sulfate chain(4) (Homo sapiens)
RHEA:67121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:33277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O
RHEA:72889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + polyporic acid + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Bos taurus)
REACT:R-DME-109538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Drosophila melanogaster)
REACT:R-HSA-9769812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike Trimer Translocates to the Plasma Membrane (Homo sapiens)
REACT:R-DME-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Drosophila melanogaster)
RHEA:22504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate
RHEA:22504	skos:prefLabel	"quercetin-3-sulfate 3'-sulfotransferase"
RHEA:22504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quercetin-3-sulfate 3'-sulfotransferase"
REACT:R-BTA-170126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin B1 in the CRS domain (Bos taurus)
RHEA:66891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5228525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)
EC:3.7.1.3	skos:altLabel	"L-kynurenine hydrolase"
EC:3.7.1.3	skos:prefLabel	"kynureninase"
EC:3.7.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kynureninase"
REACT:R-MMU-8848873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARAP1 (Mus musculus)
GO:0008012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of adult chitin-based cuticle
GO:0008012	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	structural constituent of adult cuticle
REACT:R-GGA-8956659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates YAP1 (Gallus gallus)
REACT:R-SSC-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Sus scrofa)
RHEA:33519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine = (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-DRE-2032396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3 migrates to the nucleus (Danio rerio)
RHEA:28904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(in) + H(+)(in) => D-alanine(out) + H(+)(out)
REACT:R-XTR-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Xenopus tropicalis)
RHEA:34494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N,N'-diacetylbacillosamine <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP
REACT:R-SSC-5684081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds CDK2 and RBBP8 (Sus scrofa)
REACT:R-HSA-5602242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP2U1 does not omega-hydroxylate ARA (Homo sapiens)
REACT:R-HSA-9035976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HEXA does not cleave the terminall GalNAc from small HA fragments (Homo sapiens)
REACT:R-CEL-73632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Caenorhabditis elegans)
RHEA:28957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucuronate(out) + H(+)(out) => aldehydo-D-glucuronate(in) + H(+)(in)
RHEA:37017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)
RHEA:26339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 L-methionine => L-homocysteine + S-methyl-L-methionine
RHEA:35063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyrazinamide = NH4(+) + pyrazine-2-carboxylate
REACT:R-CFA-9617996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Canis familiaris)
RHEA:38267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methylfumaryl-CoA isomerase"
RHEA:38267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylfumaryl-CoA = 3-methylfumaryl-CoA
RHEA:38267	skos:altLabel	"mesaconyl-CoA C1-C4 CoA transferase"
RHEA:38267	skos:prefLabel	"2-methylfumaryl-CoA isomerase"
REACT:R-BTA-5651789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to POLB ligates SSB (Bos taurus)
REACT:R-DME-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Drosophila melanogaster)
REACT:R-XTR-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Xenopus tropicalis)
RHEA:15124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dithioerythritol + thiosulfate <=> cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite
REACT:R-RNO-9603982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeA to form LeB (Rattus norvegicus)
REACT:R-GGA-211190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of DFF45 (117) (Gallus gallus)
REACT:R-DDI-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Dictyostelium discoideum)
RHEA:38592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine => chloroorienticin B + dTDP + H(+)
REACT:R-HSA-451649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
REACT:R-XTR-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Xenopus tropicalis)
RHEA:70878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-methionine(out) + Na(+)(out) <=> L-glutamine(out) + L-methionine(in) + Na(+)(in)
RHEA:57717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate + NH4(+) => carbamate + H(+) + H2O
RHEA:72218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + Na(+)(out) <=> 2 hydrogencarbonate(in) + Na(+)(in)
RHEA:63354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:11155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-pyridoxate + NADPH + O2 <=> 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)
RHEA:44230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-decenoyl-CoA + AMP + diphosphate => 9-decenoate + ATP + CoA
REACT:R-MMU-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Mus musculus)
REACT:R-GGA-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Gallus gallus)
REACT:R-GGA-114261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)
REACT:R-MMU-5607721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NIK (Mus musculus)
REACT:R-HSA-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Homo sapiens)
REACT:R-XTR-9018572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates NOTCH3 (Xenopus tropicalis)
RHEA:46729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2
REACT:R-CEL-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Caenorhabditis elegans)
REACT:R-DRE-1971482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Danio rerio)
RHEA:61269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminohexanoate + O2 => 2-oxohexanoate + H2O2 + NH4(+)
REACT:R-DRE-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Danio rerio)
REACT:R-DRE-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Danio rerio)
RHEA:11970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydro-7,8-dihydroxykynurenate + A => AH2 + kynurenate + O2
REACT:R-PFA-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Plasmodium falciparum)
RHEA:52861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty acid + ATP + CoA => a short-chain fatty acyl-CoA + AMP + diphosphate
REACT:R-DME-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Drosophila melanogaster)
REACT:R-GGA-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Gallus gallus)
RHEA:35591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + n sulfur = H(+) + hydrogen sulfide + (n-1) sulfur
RHEA:35591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfhydrogenase"
RHEA:35591	skos:prefLabel	"sulfhydrogenase"
RHEA:35591	skos:altLabel	"sulfur reductase"
REACT:R-HSA-9613513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLINs:HSPA8 binds PRKAA2 (Homo sapiens)
REACT:R-CFA-9706364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of ubiquitinated FLT3 (Canis familiaris)
GO:0102006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate dehydrogenase activity
GO:0102006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-methylbutanoyl-CoA + CO2 + NADH
RHEA:61386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O
REACT:R-GGA-9709317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to free ferrohemoglobin (Gallus gallus)
REACT:R-GGA-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Gallus gallus)
REACT:R-SCE-71590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)
REACT:R-RNO-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Rattus norvegicus)
RHEA:67161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + melleolide F + O2 => 6'-chloromelleolide F + FAD + H(+) + 2 H2O
REACT:R-PFA-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Plasmodium falciparum)
RHEA:49554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-lysyl-[protein] + lactate => H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]
REACT:R-MMU-264865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin A (Mus musculus)
RHEA:69675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eriodictyol-7-O-beta-D-glucoside + H2O = (S)-eriodictyol + beta-D-glucose
RHEA:57570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Danio rerio)
REACT:R-SCE-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)
RHEA:23506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-ol + adenosylcob(III)yrate => adenosylcob(III)inamide + H2O
REACT:R-MMU-6783681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIF binds LIFR (Mus musculus)
REACT:R-DRE-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Danio rerio)
RHEA:32950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA
RHEA:41634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine
REACT:R-BTA-212352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ARC coactivator complex (Bos taurus)
RHEA:17186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + NADP(+) + NH4(+) => GMP + 2 H(+) + NADPH
REACT:R-DRE-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)
REACT:R-HSA-5655289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-DDI-9020275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DHA to 17(S)-Hp-DHA (Dictyostelium discoideum)
REACT:R-BTA-8862152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Bos taurus)
REACT:R-HSA-1433508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC alpha interacts with and phosphorylates KIT (Homo sapiens)
RHEA:58618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + octanamide => N-octanoyl-(2S)-hydroxyglycine
REACT:R-DDI-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Dictyostelium discoideum)
RHEA:34330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + H(+) + NADPH + O2 <=> 1,4-benzoquinone + H2O + NADP(+) + nitrite
REACT:R-CFA-5625870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)
GO:0038006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	netrin receptor activity involved in chemoattraction
GO:0038006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	netrin receptor activity involved in positive chemotaxis
GO:0038006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	attractive netrin receptor activity
REACT:R-GGA-8875902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC45A3 transports Glc from extracellular region to cytosol (Gallus gallus)
REACT:R-CFA-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Canis familiaris)
REACT:R-CEL-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Caenorhabditis elegans)
REACT:R-HSA-1675834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane (Homo sapiens)
REACT:R-SSC-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Sus scrofa)
RHEA:55934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O
REACT:R-BTA-196350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Bos taurus)
REACT:R-XTR-5672329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CLIP1 and microtubules (Xenopus tropicalis)
RHEA:22083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + quinolin-2-ol <=> H2O + NAD(+) + quinoline-2,8-diol
REACT:R-XTR-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Xenopus tropicalis)
REACT:R-BTA-1855171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Bos taurus)
REACT:R-HSA-75883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHRS7B reduces GO3P to HXDG3P (Homo sapiens)
RHEA:13357	skos:prefLabel	"3-hydroxypropionate dehydrogenase"
RHEA:13357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH
RHEA:13357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxypropionate dehydrogenase"
REACT:R-MTU-9635480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FadD26, FadD28 transfer adenylyl group to a LCFA (Mycobacterium tuberculosis)
REACT:R-DME-352379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Drosophila melanogaster)
RHEA:30675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahymanol = H2O + squalene
RHEA:30675	skos:prefLabel	"tetrahymanol synthase"
RHEA:30675	skos:altLabel	"squalene--tetrahymanol cyclase"
RHEA:30675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrahymanol synthase"
REACT:R-BTA-2465934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL translocates from Muller cells to cone photoreceptor cells (Bos taurus)
REACT:R-RNO-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Rattus norvegicus)
REACT:R-SSC-112436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin complex (Sus scrofa)
REACT:R-CFA-193653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF homodimer binds to p75NTR (Canis familiaris)
REACT:R-SSC-9024997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Sus scrofa)
REACT:R-HSA-9695834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation of FLT3 mutants (Homo sapiens)
RHEA:25238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CDP => ADP + CTP
RHEA:53806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholate + ursodeoxycholoyl-CoA => allodeoxycholoyl-CoA + ursodeoxycholate
REACT:R-DME-2990842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO2 (Drosophila melanogaster)
REACT:R-SSC-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-SSC-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Sus scrofa)
RHEA:46625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-5-monosubstituted hydantoin => a L-5-monosubstituted hydantoin
REACT:R-GGA-5610752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R translocates to the nucleus (Gallus gallus)
REACT:R-SSC-977375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR1 binds C3bBb/C4bC2a (Sus scrofa)
REACT:R-BTA-5618328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAT acetylates microtubules (Bos taurus)
REACT:R-RNO-5228508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates PML with SUMO1 (Rattus norvegicus)
RHEA:24693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + eugenol + NADP(+) <=> (E)-coniferyl acetate + NADPH
GO:0008882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine triphosphate:glutamine synthetase adenylyltransferase activity
GO:0008882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine-synthetase adenylyltransferase activity
GO:0008882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutamate-ammonia-ligase] adenylyltransferase activity
GO:0008882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:[glutamate-ammonia-ligase] adenylyltransferase activity
GO:0008882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:glutamine synthetase adenylyltransferase activity
GO:0008882	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity
GO:0008882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-ammonia-ligase adenylyltransferase activity
RHEA:37141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate
REACT:R-MMU-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Mus musculus)
REACT:R-DDI-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Dictyostelium discoideum)
REACT:R-BTA-8952128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TP53 (Bos taurus)
REACT:R-HSA-8937442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES3 hydrolyses CHEST to CHOL and LCFA(-) (Homo sapiens)
REACT:R-DME-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Drosophila melanogaster)
REACT:R-SSC-388981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Kiss receptor GPR54 binds kisspeptin (Sus scrofa)
REACT:R-CFA-9761344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 binds IKBKG within IKK complex (Canis familiaris)
REACT:R-HSA-8951595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Homo sapiens)
REACT:R-BTA-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Bos taurus)
REACT:R-DME-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)
REACT:R-BTA-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Bos taurus)
RHEA:44873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-HSA-5617676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA3 gene is transcribed (Homo sapiens)
REACT:R-BTA-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Bos taurus)
REACT:R-HSA-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Homo sapiens)
REACT:R-MMU-5696945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates CCP110,ARRB (Mus musculus)
REACT:R-MMU-5653770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)
REACT:R-PFA-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Plasmodium falciparum)
RHEA:43632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)
GO:0103117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
EC:1.13.11.77	skos:altLabel	"10S-dioxygenase"
EC:1.13.11.77	skos:altLabel	"10S-DOX"
EC:1.13.11.77	skos:altLabel	"(10S)-dioxygenase"
EC:1.13.11.77	skos:prefLabel	"oleate 10S-lipoxygenase"
EC:1.13.11.77	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oleate 10S-lipoxygenase"
REACT:R-MMU-4551768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO2,3 (Mus musculus)
REACT:R-BTA-8950210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 dissociates from Interleukin-27 receptor (Bos taurus)
REACT:R-MMU-210271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and MDL-1 (Mus musculus)
REACT:R-DRE-171141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Danio rerio)
REACT:R-XTR-173636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of classic pathway C5 convertase (Xenopus tropicalis)
RHEA:34272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitroimidazole + H2O => 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite
RHEA:50573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]
REACT:R-MMU-8938815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 polyubiquitinates RRAGA (Mus musculus)
RHEA:41058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA
RHEA:38384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)
REACT:R-DRE-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Danio rerio)
REACT:R-DRE-373071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR7 binds CCL19 and 21 ligands (Danio rerio)
RHEA:33041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin
REACT:R-CFA-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Canis familiaris)
RHEA:39677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA => (9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA
REACT:R-CEL-1254248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80:YAP1 complex to the nucleus (Caenorhabditis elegans)
REACT:R-SPO-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Schizosaccharomyces pombe)
REACT:R-GGA-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Gallus gallus)
REACT:R-MMU-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Mus musculus)
REACT:R-RNO-6784319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,TYK2 phosphorylate JAK1,TYK2 (Rattus norvegicus)
RHEA:70327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) = 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH
RHEA:59389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid ester + H2O => a fatty acid + an aliphatic alcohol + H(+)
RHEA:69164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) = 2 H(+) + N-(2-carboxyethyl)putrescine + NADH
REACT:R-DME-9007539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates E2F6 (Drosophila melanogaster)
REACT:R-CFA-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Canis familiaris)
REACT:R-DME-1889978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALT6 transfers Gal to the tetrasaccharide linker (Drosophila melanogaster)
RHEA:36545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate => H2O + mycothiol S-conjugate
RHEA:60004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate
REACT:R-CFA-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Canis familiaris)
REACT:R-RNO-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Rattus norvegicus)
RHEA:34525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose
REACT:R-RNO-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Rattus norvegicus)
REACT:R-MMU-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Mus musculus)
REACT:R-RNO-3000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BORA binds PLK1 and AURKA (Rattus norvegicus)
REACT:R-GGA-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Gallus gallus)
REACT:R-RNO-5617815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binds RAB3IP (Rattus norvegicus)
REACT:R-MMU-2426566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and CLM7 (Mus musculus)
EC:2.8.5.-	skos:prefLabel	"Thiosulfotransferases"
EC:2.8.5.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Thiosulfotransferases"
GO:0102051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-tryptophan synthetase activity
REACT:R-CFA-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Canis familiaris)
GO:0044102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine deoxyribosyltransferase activity
GO:0044102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine 2'-deoxyribosyltransferase activity
GO:0044102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTD
REACT:R-HSA-8854899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Homo sapiens)
REACT:R-MMU-3108203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO2,3 (Mus musculus)
RHEA:16653	skos:prefLabel	"gluconate 2-dehydrogenase"
RHEA:16653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gluconate 2-dehydrogenase"
RHEA:16653	skos:altLabel	"2-ketogluconate reductase"
RHEA:16653	skos:altLabel	"2-keto-D-gluconate reductase"
RHEA:16653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + NADP(+) = 2-dehydro-D-gluconate + H(+) + NADPH
RHEA:20728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glutamate oxidase"
RHEA:20728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + O2 = 2-oxoglutarate + H2O2 + NH4(+)
RHEA:20728	skos:prefLabel	"L-glutamate oxidase"
RHEA:61522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-tyramine + A + H2O => AH2 + dopamine
RHEA:45547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
REACT:R-DRE-5250947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH complex binds rDNA promoter (Danio rerio)
RHEA:72080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + selenate(out) => 3 Na(+)(in) + selenate(in)
RHEA:62797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + 2 rubrofusarin B => aurasperone A + 2 H2O + NADP(+)
REACT:R-DME-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Drosophila melanogaster)
REACT:R-GGA-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Gallus gallus)
RHEA:30106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-didehydro-D-gluconate + H(+) + NADH <=> 5-dehydro-D-gluconate + NAD(+)
REACT:R-BTA-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Bos taurus)
RHEA:30181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + reduced 2[4Fe-4S]-[ferredoxin] => oxalate + oxidized 2[4Fe-4S]-[ferredoxin]
RHEA:22481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH
GO:0043905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ser-tRNA(Thr) hydrolase activity
GO:0043905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ser-tRNAThr hydrolase activity
REACT:R-CEL-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-MMU-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Mus musculus)
REACT:R-SSC-6798317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Sus scrofa)
REACT:R-MMU-5246478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOM binds retinoids (Mus musculus)
RHEA:69411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) <=> androst-4-ene-3,11,17-trione + H(+) + NADH
REACT:R-CEL-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Caenorhabditis elegans)
REACT:R-DME-3640858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase ADP-ribosylates AXIN (Drosophila melanogaster)
REACT:R-GGA-8950780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 binds p-Y693-STAT4 (Gallus gallus)
REACT:R-CFA-158942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)
REACT:R-HSA-203662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)
REACT:R-CFA-6784423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Canis familiaris)
GO:0050091	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	melilotic hydroxylase activity
GO:0050091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melilotate hydroxylase activity
GO:0050091	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)
GO:0050091	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxyphenylpropionate hydroxylase activity
GO:0050091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melilotate 3-monooxygenase activity
GO:0050091	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxyphenylpropionic hydroxylase activity
REACT:R-CFA-352174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Canis familiaris)
GO:0042609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD4 receptor binding
REACT:R-DRE-5692781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Danio rerio)
RHEA:24303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(I)yrinate a,c diamide + FMN + 3 H(+) <=> 2 cob(II)yrinate a,c diamide + FMNH2
REACT:R-CFA-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Canis familiaris)
REACT:R-XTR-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Xenopus tropicalis)
REACT:R-HSA-448744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20RA binds IL20RB (Homo sapiens)
REACT:R-RNO-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Rattus norvegicus)
REACT:R-BTA-373716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacting NCK-1 (Bos taurus)
REACT:R-DRE-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Danio rerio)
REACT:R-CFA-5624132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Canis familiaris)
REACT:R-DRE-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Danio rerio)
REACT:R-XTR-5696183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC3 deaminates BZAM (Xenopus tropicalis)
RHEA:71969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate(in) + 3 Na(+)(in) => (S)-2-hydroxyglutarate(out) + 3 Na(+)(out)
REACT:R-RNO-162742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Rattus norvegicus)
RHEA:60037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate => 3-hydroxy-3-methylhexanoate + L-glutamine
REACT:R-MMU-373358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR6 binds CXCL16 ligand (Mus musculus)
REACT:R-DME-113402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:early elongation complex (Drosophila melanogaster)
REACT:R-MMU-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Mus musculus)
GO:0033849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrysanthemyl diphosphate synthase activity
GO:0033849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPPase activity
GO:0033849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity
REACT:R-SSC-1655879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiosulfate can transfer its sulfur atom to glutathione (Sus scrofa)
REACT:R-HSA-5359451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from SAM to NAM to form MNA (Homo sapiens)
REACT:R-BTA-1358795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitination of RNF41 by P-USP8 (Bos taurus)
REACT:R-CEL-6781922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds UFD1L:SKP2 (Caenorhabditis elegans)
RHEA:55221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
EC:3.2.1.171	skos:prefLabel	"rhamnogalacturonan hydrolase"
EC:3.2.1.171	skos:altLabel	"RG-hydrolase"
EC:3.2.1.171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnogalacturonan hydrolase"
RHEA:10995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + NADP(+) <=> glyoxylate + H(+) + NADPH
RHEA:12830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-methyl-L-aspartate => mesaconate + NH4(+)
RHEA:62742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)
REACT:R-DRE-3788748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL6 promoter (Danio rerio)
REACT:R-MMU-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Mus musculus)
RHEA:17326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA => (S)-2-succinylamino-6-oxoheptanedioate + CoA
RHEA:63213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + methylglyoxal => 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O
RHEA:54643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate <=> (12E)-labda-8(17),12,14-triene + diphosphate
RHEA:30854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate
RHEA:34154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine <=> 2-deoxystreptamine + 2-oxoglutaramate
RHEA:56609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydrosulfopterin + glycine + H2O => L-serine + tetrahydrosulfopterin
REACT:R-XTR-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)
REACT:R-HSA-8954468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Homo sapiens)
RHEA:34483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzalacetone synthase"
RHEA:34483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = 4-hydroxybenzalacetone + 2 CO2 + 2 CoA
RHEA:34483	skos:prefLabel	"benzalacetone synthase"
RHEA:33489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA
RHEA:10371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
REACT:R-HSA-9679816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIGMAR1 binds dextromethorphan (Homo sapiens)
REACT:R-HSA-1234179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
RHEA:41022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA
RHEA:58960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H2O + O2 = benzoate + H(+) + H2O2
RHEA:14757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone = 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate
GO:0070284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMP-P synthase activity
GO:0070284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity
GO:0070284	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ThiC
REACT:R-HSA-2127257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Homo sapiens)
RHEA:62414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + vanillin => (E)-feruloyl-CoA + H2O
RHEA:34220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH
RHEA:17305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline
RHEA:35455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 = (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)
REACT:R-GGA-1236398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds NRGs or EGF-like ligands (Gallus gallus)
REACT:R-PFA-5661115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Plasmodium falciparum)
REACT:R-HSA-419003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Nectins with Afadin (Homo sapiens)
REACT:R-GGA-417127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation and translocation of the extended telomeric chromosome end (Gallus gallus)
REACT:R-XTR-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Xenopus tropicalis)
RHEA:35953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate
REACT:R-GGA-420265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind IAPP(34-70) (Gallus gallus)
RHEA:32150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sepiapterin <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)
REACT:R-RNO-4088024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Rattus norvegicus)
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	reductase kinase activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme A reductase kinase activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl-CoA reductase kinase activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HMG-CoA reductase kinase activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMPK
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl-CoA reductase kinase activity
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK29
GO:0047322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity
RHEA:35298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-molybdopterin + H(+) + tungstate <=> AMP + H2O + W-molybdopterin cofactor
REACT:R-HSA-9613023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates (Homo sapiens)
REACT:R-DME-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Drosophila melanogaster)
REACT:R-HSA-5660503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CSRP1 (Homo sapiens)
REACT:R-XTR-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Xenopus tropicalis)
REACT:R-PFA-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Plasmodium falciparum)
REACT:R-CFA-165758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and inactivation of eEF2K by activated S6K1 (Canis familiaris)
RHEA:53513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate
REACT:R-MMU-9609742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Mus musculus)
REACT:R-GGA-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Gallus gallus)
RHEA:47712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-3-hydroxy-L-proline = cis-3-hydroxy-D-proline
REACT:R-RNO-5357828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8 (Rattus norvegicus)
REACT:R-CFA-873918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of JAK1 (Canis familiaris)
REACT:R-CFA-9012657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)
REACT:R-DRE-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Danio rerio)
REACT:R-DME-193696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Drosophila melanogaster)
RHEA:23057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea => cyanamide + H2O
REACT:R-MMU-2730868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK7 by MEKK1 (Mus musculus)
REACT:R-RNO-9678935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Rattus norvegicus)
REACT:R-MMU-1482543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Mus musculus)
REACT:R-MMU-5661114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Mus musculus)
REACT:R-RNO-6801766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Rattus norvegicus)
RHEA:39694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH <=> (11Z)-octadecenoyl-CoA + NADP(+)
RHEA:53169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
RHEA:25162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + L-glutamate 5-semialdehyde => 2-oxoglutarate + L-ornithine
GO:0016852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-sirohydrochlorin + 2 H(+) = Co(2+) + sirohydrochlorin
GO:0016852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sirohydrochlorin cobalt-lyase activity
GO:0016852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)
GO:0016852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sirohydrochlorin cobaltochelatase activity
GO:0016852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobaltochelatase
GO:0016852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anaerobic cobalt chelatase activity
REACT:R-HSA-8935730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter (Homo sapiens)
RHEA:23394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n a ribonucleoside 5'-phosphate + n H(+) => (n-1) H2O + RNA(n)
REACT:R-DDI-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Dictyostelium discoideum)
EC:3.1.3.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[glycogen-synthase-D] phosphatase"
EC:3.1.3.42	skos:prefLabel	"[glycogen-synthase-D] phosphatase"
REACT:R-HSA-933523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)
RHEA:41444	skos:prefLabel	"2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)"
RHEA:41444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + 2 H(+) + phosphate
RHEA:41444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)"
GO:0018489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vanillate demethylase activity
GO:0018489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-3-methoxybenzoate demethylase activity
GO:0018489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vanillate:oxygen oxidoreductase (demethylating)
GO:0018489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vanillate demethylase (aerobic) activity
GO:0018489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vanillate monooxygenase activity
REACT:R-DME-209309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated REL-68 transports from the cytosol to the nucleus (Drosophila melanogaster)
REACT:R-HSA-8981093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12 bound to IL12R internalises (Homo sapiens)
REACT:R-SSC-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Sus scrofa)
REACT:R-DRE-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Danio rerio)
GO:0001056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III transcribes microbial dsDNA to dsRNA (Homo sapiens)
GO:0001056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III activity
GO:0001056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter
REACT:R-DRE-202466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Bcl10 to CARMA1 (Danio rerio)
REACT:R-SSC-1678708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(2) (Sus scrofa)
RHEA:34166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone + O2 <=> (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)
GO:0042910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multidrug efflux pump activity
GO:0042910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	drug transmembrane transporter activity
GO:0042910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multidrug, alkane resistant pump activity
GO:0042910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multidrug transporter activity
GO:0042910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xenobiotic transmembrane transporter activity
GO:0042910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xenobiotic transporter activity
GO:0042910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	drug transporter activity
GO:0140598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoprotein carrier activity
RHEA:30648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + CTP + H(+) => CDP-1L-myo-inositol + diphosphate
RHEA:10244	skos:altLabel	"fumarylacetoacetate hydrolase"
RHEA:10244	skos:prefLabel	"fumarylacetoacetase"
RHEA:10244	skos:altLabel	"beta-diketonase"
RHEA:10244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumarylacetoacetase"
RHEA:10244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)
RHEA:52484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2
RHEA:52484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2
RHEA:52484	skos:altLabel	"T3R"
RHEA:52484	skos:prefLabel	"3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase"
RHEA:52484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase"
RHEA:52484	skos:altLabel	"tabersonine 3-reductase"
REACT:R-DRE-202478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction and oligomerization of MALT1 to Bcl10 (Danio rerio)
RHEA:46452	skos:prefLabel	"cyclo(L-leucyl-L-leucyl) synthase"
RHEA:46452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-leucyl-tRNA(Leu) = cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)
RHEA:46452	skos:altLabel	"cyclodileucine synthase"
RHEA:46452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclo(L-leucyl-L-leucyl) synthase"
REACT:R-RNO-8982645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRKs bind ADRB2:Catecholamine (Rattus norvegicus)
RHEA:71895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide
RHEA:57064	skos:prefLabel	"D-apionolactonase"
RHEA:57064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-apionolactonase"
RHEA:57064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apionolactone + H2O = D-apionate + H(+)
RHEA:50336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate = H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]
GO:0000286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dependent alanine dehydrogenase activity
GO:0000286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine:NAD+ oxidoreductase (deaminating)
GO:0000286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine dehydrogenase activity
GO:0000286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked alanine dehydrogenase activity
GO:0000286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine oxidoreductase activity
GO:0000286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AlaDH
GO:0000286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent alanine dehydrogenase activity
GO:0000286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine dehydrogenase activity
GO:0000286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-alanine dehydrogenase activity
REACT:R-CFA-5607058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C:PROCR binds F2R (Canis familiaris)
RHEA:50478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => anthraniloyl-CoA + L-cysteinyl-[PqsD protein]
REACT:R-CEL-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Caenorhabditis elegans)
REACT:R-DME-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Drosophila melanogaster)
REACT:R-SSC-349444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of COP1 at Ser-387  by ATM (Sus scrofa)
REACT:R-HSA-83650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FasL:Fas binds FADD (Homo sapiens)
REACT:R-DRE-432909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Plectin with Integrin beta 4 (Danio rerio)
RHEA:55500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-decanoylglycerol + H2O <=> decanoate + glycerol + H(+)
REACT:R-BTA-9668419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)
GO:0047016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity
GO:0047016	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3beta-hydroxy-delta5-C27-steroid oxidoreductase
GO:0047016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity
GO:0047016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
GO:0047016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity
GO:0010285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity
GO:0010285	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LL-DAP aminotransferase activity
GO:0010285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LL-diaminopimelate aminotransferase activity
GO:0010285	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LL-DAP-AT activity
GO:0010285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L,L-diaminopimelate aminotransferase activity
GO:0010285	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LL-diaminopimelate transaminase activity
REACT:R-CEL-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Caenorhabditis elegans)
REACT:R-RNO-5340214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB binds O2 (Rattus norvegicus)
RHEA:63172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oyl-CoA = (25R)-3-oxocholest-4-en-26-oyl-CoA
REACT:R-XTR-190265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds to FGF (Xenopus tropicalis)
RHEA:57866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:61766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + rebaudioside E + UDP => stevioside + UDP-alpha-D-glucose
GO:0052716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-diphenol:oxygen oxidoreductase activity
GO:0052716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone:oxygen oxidoreductase activity
GO:0052716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O
GO:0052716	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	benzenediol:oxygen oxidoreductase activity
GO:0052716	skos:prefLabel	"laccase"
GO:0052716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"laccase"
GO:0052716	skos:altLabel	"urishiol oxidase"
GO:0052716	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	laccase reaction
RHEA:41691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate
RHEA:64540	skos:prefLabel	"mannosyl-inositol-phosphoceramide inositolphosphotransferase"
RHEA:64540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosyl-inositol-phosphoceramide inositolphosphotransferase"
RHEA:64540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base
RHEA:28520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-beta-D-manno-heptose 1-phosphate + phosphate => D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O
REACT:R-DME-3928656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves EPHB2 (Drosophila melanogaster)
REACT:R-CFA-9718020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PTGFR agonists (Canis familiaris)
REACT:R-BTA-212380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TRAP coactivator complex (Bos taurus)
RHEA:72409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Li(+)(in) => H(+)(in) + Li(+)(out)
REACT:R-BTA-1605723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Bos taurus)
REACT:R-DDI-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Dictyostelium discoideum)
EC:2.4.2.61	skos:prefLabel	"alpha-dystroglycan beta1,4-xylosyltransferase"
EC:2.4.2.61	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-dystroglycan beta1,4-xylosyltransferase"
RHEA:25726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:36194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine
REACT:R-DRE-373705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of DCC (Danio rerio)
REACT:R-RNO-9626880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Rattus norvegicus)
RHEA:49449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O => alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose
RHEA:57711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP
RHEA:67254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + 2 H(+) + NADH => H2O + malonaldehyde + NAD(+)
REACT:R-MMU-209063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Mus musculus)
REACT:R-DME-8942607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Drosophila melanogaster)
RHEA:45816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + A = AH2 + pyruvate
REACT:R-HSA-9021451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter (Homo sapiens)
REACT:R-CFA-8956140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 and UBD bind NUB1 and the 26S proteasome (Canis familiaris)
REACT:R-DDI-8938773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A polyubiquitinates PRKDC (Dictyostelium discoideum)
REACT:R-DDI-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Dictyostelium discoideum)
RHEA:17594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-glutamine => 2-oxoglutaramate + L-phenylalanine
RHEA:22172	skos:altLabel	"sucrosephosphate--UDP glucosyltransferase"
RHEA:22172	skos:altLabel	"UDP-glucose-fructose-phosphate glucosyltransferase"
RHEA:22172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = H(+) + sucrose 6(F)-phosphate + UDP
RHEA:22172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sucrose-phosphate synthase"
RHEA:22172	skos:prefLabel	"sucrose-phosphate synthase"
RHEA:72594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate(out) + H(+)(out) <=> D-glucuronate(in) + H(+)(in)
REACT:R-HSA-9630055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTHL1 D239Y does not cleave dihydrouracil (DHU) (Homo sapiens)
REACT:R-DME-170847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)
REACT:R-BTA-3000449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Bos taurus)
RHEA:51857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) => (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
REACT:R-CEL-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Caenorhabditis elegans)
RHEA:36859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA
REACT:R-XTR-428205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [Golgi] (Xenopus tropicalis)
RHEA:38587	skos:prefLabel	"vancomycin aglycone glucosyltransferase"
RHEA:38587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vancomycin aglycone = devancoaminyl-vancomycin + UDP
RHEA:38587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vancomycin aglycone glucosyltransferase"
RHEA:13705	skos:prefLabel	"mannotetraose 2-alpha-N-acetylglucosaminyltransferase"
RHEA:13705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine = alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP
RHEA:13705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannotetraose 2-alpha-N-acetylglucosaminyltransferase"
RHEA:13705	skos:altLabel	"alpha-N-acetylglucosaminyltransferase"
REACT:R-MMU-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Mus musculus)
REACT:R-CFA-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Canis familiaris)
REACT:R-DME-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Drosophila melanogaster)
RHEA:40132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H2O => (9Z)-hexadecenoate + CoA + H(+)
REACT:R-BTA-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)
RHEA:33593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosanoylsphinganine => sphinganine + tetracosanoyl-CoA
RHEA:68583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-kynurenine(out) <=> ADP + H(+) + L-kynurenine(in) + phosphate
RHEA:39492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)
RHEA:27558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 2 diphosphate
REACT:R-PFA-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Plasmodium falciparum)
REACT:R-SSC-77263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Sus scrofa)
RHEA:39256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)
REACT:R-CFA-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Canis familiaris)
REACT:R-HSA-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Homo sapiens)
RHEA:30076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H2O => cytosine + D-ribose 5-phosphate
RHEA:46833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-HSA-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Homo sapiens)
REACT:R-MMU-392195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi activation by P2Y purinoceptor 12 (Mus musculus)
RHEA:64785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-ethyl-L-cysteine => 2-aminoprop-2-enoate + ethanethiol
REACT:R-CEL-8876615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB13 GEFs exchange GTP for GDP on RAB13 (Caenorhabditis elegans)
REACT:R-DRE-417825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y11 receptor can bind to ATP (Danio rerio)
RHEA:29266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(in) + Na(+)(in) <=> L-leucine(out) + Na(+)(out)
REACT:R-MMU-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Mus musculus)
RHEA:13272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-glucose
RHEA:29778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate + ATP <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)
REACT:R-SSC-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Sus scrofa)
REACT:R-CFA-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)
REACT:R-SPO-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Schizosaccharomyces pombe)
REACT:R-DRE-193997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B1 oxidises 11DCORT (Danio rerio)
RHEA:59332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-hydroxy-gamma-carotene + A = 1'-hydroxytorulene + AH2
REACT:R-MMU-9674131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 binds ATM dimer:Ub-p-PEX5 (Mus musculus)
REACT:R-CEL-3928612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KALRN exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
RHEA:71028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-phenylalanine(out) => L-glutamine(out) + L-phenylalanine(in)
RHEA:38209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Drosophila melanogaster)
RHEA:10770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2
REACT:R-CEL-5638006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3 hydrolyzes GTP (Caenorhabditis elegans)
RHEA:32478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + 3 S-adenosyl-L-methionine <=> glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-CFA-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
GO:0042242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobyrinate a c diamide synthase activity
GO:0042242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobyrinate a c-diamide synthase activity
GO:0042242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobyrinic acid a,c-diamide synthase activity
GO:0042242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobyrinate a,c diamide synthase activity
GO:0042242	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CobB
GO:0042242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobyrinate a,c-diamide synthase activity
REACT:R-BTA-451942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Within the IL-2R complex JAK3 phosphorylates JAK1 (Bos taurus)
RHEA:36605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-enduracididine + CO2 + succinate => 2-oxoglutarate + L-enduracididine + O2
RHEA:15095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-tyrosine
REACT:R-GGA-1671687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR activation (Gallus gallus)
RHEA:64513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine
REACT:R-DDI-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Dictyostelium discoideum)
REACT:R-BTA-158357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIIa binds SERPING1 (Bos taurus)
REACT:R-CFA-183089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)
RHEA:52926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate
REACT:R-HSA-264871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin B1 (Homo sapiens)
REACT:R-DME-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Drosophila melanogaster)
REACT:R-DRE-8855915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Danio rerio)
REACT:R-XTR-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Xenopus tropicalis)
RHEA:66726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-[(S)-lactoyl]-L-phenylalanine => (S)-lactate + L-phenylalanine
RHEA:36290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)
RHEA:13770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NAD(+) => dihydroxyacetone + H(+) + NADH
REACT:R-RNO-5250209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP binds SLC25A4 (Rattus norvegicus)
RHEA:10868	skos:altLabel	"diglyceride acyltransferase"
RHEA:10868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diacylglycerol O-acyltransferase"
RHEA:10868	skos:prefLabel	"diacylglycerol O-acyltransferase"
RHEA:10868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA
REACT:R-BTA-140736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Bos taurus)
REACT:R-BTA-209910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is taken up by thyroid epithelial cells (Bos taurus)
REACT:R-XTR-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Xenopus tropicalis)
REACT:R-CFA-141046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Canis familiaris)
RHEA:57561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:62989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanamide + H2O => dodecanoate + NH4(+)
REACT:R-MMU-914036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)
RHEA:50800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin A2 = prostaglandin A2-S-(S)-glutathione
REACT:R-DRE-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Danio rerio)
GO:0018796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)
GO:0018796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,5-dihydroxyphthalate carboxy-lyase activity
GO:0018796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-dihydroxyphthalate decarboxylase activity
REACT:R-XTR-4093331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ras:GTP binds p120-RasGAP (Xenopus tropicalis)
RHEA:11182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn) => ATP + L-asparagine + tRNA(Asn)
RHEA:29711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine(in) + H(+)(in) = cadaverine(out) + H(+)(out)
EC:1.6.-.-	skos:prefLabel	"Acting on NADH or NADPH"
EC:1.6.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on NADH or NADPH"
RHEA:52855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]
REACT:R-HSA-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Homo sapiens)
REACT:R-HSA-508282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK is a substrate for JAK1 (Homo sapiens)
REACT:R-BTA-9645481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIFA oligomerization (Bos taurus)
REACT:R-DRE-879562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Danio rerio)
REACT:R-GGA-9706390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds interacting proteins at trans-Golgi network (Gallus gallus)
REACT:R-BTA-9756162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)
REACT:R-HSA-3232162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates MITF with SUMO1 (Homo sapiens)
RHEA:39401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA
REACT:R-MMU-2395873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)
REACT:R-DDI-5674019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds KSR1:MARK3 (Dictyostelium discoideum)
REACT:R-MMU-4655374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DNMT3B with SUMO1 (Mus musculus)
GO:0008239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dipeptidyl-peptidase activity
REACT:R-HSA-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Homo sapiens)
RHEA:13480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan + NADP(+) <=> H(+) + indole-3-pyruvate + NADPH + NH4(+)
REACT:R-GGA-8941623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)
RHEA:59516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylsalicylate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate
GO:0032778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalt transporting ATPase activity
GO:0032778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type cobalt transporter activity
GO:0032778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalt-transporting ATPase activity
GO:0032778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalt porter activity
GO:0032778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent cobalt transmembrane transporter activity
GO:0032778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled cobalt transmembrane transporter activity
GO:0032778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Co(2+)(out) + H2O = ADP + Co(2+)(in) + H(+) + phosphate
REACT:R-HSA-2250301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyrrole cross-links (Homo sapiens)
RHEA:17032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin + H2O <=> allantoate + H(+)
REACT:R-HSA-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Homo sapiens)
RHEA:55735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)
REACT:R-SSC-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Sus scrofa)
REACT:R-SPO-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Schizosaccharomyces pombe)
REACT:R-DDI-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Dictyostelium discoideum)
RHEA:27655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + H(+) + pyruvate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2
REACT:R-RNO-352232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)
REACT:R-HSA-9605609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Homo sapiens)
RHEA:38229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanyl (9Z)-octadecenoate => (9Z)-octadecenoyl-CoA + hexadecan-1-ol
RHEA:32902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-cineole + O2 + reduced [flavodoxin] <=> 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]
RHEA:16874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)
RHEA:45476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-374207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled estrogen receptor 1 binds estrogen non-classically (Rattus norvegicus)
REACT:R-DRE-204773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb7 (Danio rerio)
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hypoxanthine-guanine phosphoribosyltransferase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanylate pyrophosphorylase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Transphosphoribosidase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine-6-thiol phosphoribosyltransferase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	guanine-hypoxanthine phosphoribosyltransferase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine phosphoribosyltransferase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine phosphoribosyltransferase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanylic pyrophosphorylase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-phosphate pyrophosphorylase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPRT
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-mercaptopurine phosphoribosyltransferase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GMP pyrophosphorylase activity
GO:0052657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxypurine phosphoribosyltransferase activity
GO:0004967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucagon receptor activity
REACT:R-DRE-170672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Danio rerio)
RHEA:28985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite(out) => nitrite(in)
REACT:R-BTA-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Bos taurus)
RHEA:64143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-asparagine + H2O <=> a fatty acid + L-asparagine
RHEA:12153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4S,5S,6R)-pentachlorocyclohexene => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)
REACT:R-CEL-443439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-Src binds Raf1 (Caenorhabditis elegans)
REACT:R-SPO-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Schizosaccharomyces pombe)
REACT:R-RNO-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Rattus norvegicus)
REACT:R-RNO-8948034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds LDL:LRP8 (Rattus norvegicus)
RHEA:42877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine
RHEA:31859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = glutinol
RHEA:31859	skos:prefLabel	"glutinol synthase"
RHEA:31859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutinol synthase"
REACT:R-XTR-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Xenopus tropicalis)
REACT:R-SSC-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Sus scrofa)
RHEA:12733	skos:altLabel	"nicotinate-nucleotide pyrophosphorylase (carboxylating)"
RHEA:12733	skos:altLabel	"quinolinate phosphoribosyltransferase (decarboxylating)"
RHEA:12733	skos:prefLabel	"nicotinate-nucleotide diphosphorylase (carboxylating)"
RHEA:12733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinate-nucleotide diphosphorylase (carboxylating)"
RHEA:12733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate
REACT:R-HSA-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Homo sapiens)
RHEA:40221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + malonate => H2O + malonyl-CoA
REACT:R-DDI-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Dictyostelium discoideum)
REACT:R-DDI-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Dictyostelium discoideum)
RHEA:42497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate => 10-deacetyl-2-debenzoylbaccatin III
RHEA:21915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + O2 + pyruvate <=> acetyl-CoA + CO2 + H2O2
RHEA:42743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:64123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-serine + H2O <=> a fatty acid + L-serine
RHEA:64463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate
RHEA:43837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADPH + O2 => 26-hydroxycholesterol + H2O + NADP(+)
RHEA:64789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + ATP + CoA => (E)-cinnamoyl-CoA + AMP + diphosphate
REACT:R-SSC-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Sus scrofa)
RHEA:60258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + formaldehyde + L-lysyl(4)-[histone H3] => A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3]
RHEA:46263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Danio rerio)
REACT:R-DRE-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Danio rerio)
RHEA:48376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)
GO:0034784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pivalyl-CoA mutase activity
REACT:R-CEL-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Caenorhabditis elegans)
REACT:R-DRE-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Danio rerio)
REACT:R-MMU-9689680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNG inhibitors (Mus musculus)
REACT:R-MMU-9018894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Mus musculus)
REACT:R-MMU-1306969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)
REACT:R-XTR-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Xenopus tropicalis)
REACT:R-DRE-1433374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processing of SCF isoform 1 (Danio rerio)
RHEA:72853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(in) + AMP(out) => ADP(out) + AMP(in)
REACT:R-HSA-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Homo sapiens)
REACT:R-MMU-1013013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)
RHEA:66776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + uroporphyrin III(in) = ADP + H(+) + phosphate + uroporphyrin III(out)
REACT:R-CEL-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Caenorhabditis elegans)
REACT:R-BTA-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)
REACT:R-GGA-203973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle budding (Gallus gallus)
REACT:R-GGA-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Gallus gallus)
REACT:R-CFA-8985201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL (Canis familiaris)
REACT:R-DRE-199093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXADR binds to AMICA1 (Danio rerio)
REACT:R-MMU-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Mus musculus)
RHEA:34421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-pinoresinol + H(+) + NADPH => (+)-lariciresinol + NADP(+)
GO:0032037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin I heavy chain binding
REACT:R-GGA-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)
REACT:R-HSA-352268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Satb1 (Homo sapiens)
RHEA:66838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
REACT:R-DDI-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Dictyostelium discoideum)
REACT:R-SSC-450551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 binds translation and heat shock proteins (Sus scrofa)
RHEA:36063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kunzeaol synthase"
RHEA:36063	skos:prefLabel	"kunzeaol synthase"
RHEA:36063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = diphosphate + kunzeaol
RHEA:48142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite => 2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0140947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9me2 methyltransferase activity
GO:0140947	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K9 trimethylation
GO:0140947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone dimethyl-lysine(H3K9) N-methyltransferase activity (H3-K9 specific)
GO:0140947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9me2 methylase activity
GO:0140947	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K9 trimethylation
GO:0015272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM). (Homo sapiens)
GO:0015272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-activated inward rectifier potassium channel activity
REACT:R-MMU-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Mus musculus)
REACT:R-MMU-379382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates DA to DOPAC (Mus musculus)
REACT:R-RNO-9027628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises EPA to 5-HEPE (Rattus norvegicus)
REACT:R-HSA-5686410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLM mediates dissolution of double Holliday junction (Homo sapiens)
REACT:R-SSC-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Sus scrofa)
REACT:R-BTA-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Bos taurus)
REACT:R-CFA-873921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of STAT1 to p-IFNGR1 (Canis familiaris)
REACT:R-SSC-2022396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-43) (Sus scrofa)
REACT:R-DDI-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Dictyostelium discoideum)
REACT:R-DRE-6787737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3R binds CSF3 dimer (Danio rerio)
REACT:R-CEL-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Caenorhabditis elegans)
REACT:R-SSC-193703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta is activated (Sus scrofa)
RHEA:55051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-dodecadienoyl-CoA + H2O <=> (3E,5Z)-dodecadienoate + CoA + H(+)
RHEA:59565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => H(+) + N,N',N'',N'''-tetraacetylchitotetraonate
RHEA:71269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-pipecolate(in) + 2 Na(+)(in) => chloride(out) + L-pipecolate(out) + 2 Na(+)(out)
REACT:R-BTA-6781814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 deubiquitinates RNF123 (Bos taurus)
REACT:R-RNO-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Rattus norvegicus)
REACT:R-SSC-1369017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in muscle cells (Sus scrofa)
RHEA:51501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-D-muramate 6-phosphate
RHEA:49326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-capsorubin => (5R,6S)-5,6-epoxi-capsanthin
REACT:R-RNO-5654594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
RHEA:32428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-isodihydrocarvone + A => (S)-carvone + AH2
RHEA:13198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + sulfite + UDP-alpha-D-glucose => H2O + UDP-alpha-D-6-sulfoquinovose
REACT:R-SCE-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-CFA-9750016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Canis familiaris)
REACT:R-CFA-5610725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TULP3 is required for GPR161 localization in the cilium (Canis familiaris)
REACT:R-CEL-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)
REACT:R-XTR-8954398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer hydrolyses cardiolipin to PA and PG (Xenopus tropicalis)
REACT:R-HSA-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Homo sapiens)
REACT:R-RNO-937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
REACT:R-XTR-5686587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates RAD52 (Xenopus tropicalis)
REACT:R-BTA-70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Bos taurus)
GO:0005252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	open rectifier potassium channel activity
REACT:R-MMU-71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Mus musculus)
GO:0102251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-10'-apo-beta-carotenal + O2 = (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone
GO:0102251	skos:altLabel	"carotenoid cleavage dioxygenase 8"
GO:0102251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-apo-10'-carotenal cleavage oxygenase activity
GO:0102251	skos:prefLabel	"all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase"
GO:0102251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase"
REACT:R-DME-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Drosophila melanogaster)
RHEA:48445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol
REACT:R-HSA-6799733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Semiquinone reacts with oxygen (Homo sapiens)
REACT:R-XTR-8853753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Xenopus tropicalis)
REACT:R-CEL-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Caenorhabditis elegans)
REACT:R-BTA-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)
REACT:R-HSA-3323050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNRD2 catalyzes the reduction of TXN2 by NADPH (Homo sapiens)
REACT:R-BTA-1236965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Export of peptide loaded MHC class I complex to PM (Bos taurus)
REACT:R-GGA-5688276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT4 transfers ADPRib to GLUD (Gallus gallus)
GO:0005364	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	maltose permease
GO:0005364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose:proton symporter activity
GO:0005364	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogen/maltose transporter activity
GO:0005364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose:hydrogen symporter activity
REACT:R-RNO-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Rattus norvegicus)
REACT:R-MMU-8848663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADIPOQ trimer binds ADIPOR dimers (Mus musculus)
RHEA:64665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)
GO:0042809	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calciferol receptor binding
GO:0042809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear vitamin D receptor binding
GO:0042809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR binding
GO:0042809	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	vitamin D receptor binding
RHEA:71252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylopyranose => L-xylulose
REACT:R-CEL-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Caenorhabditis elegans)
RHEA:65680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine
RHEA:59262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O
REACT:R-CEL-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Caenorhabditis elegans)
REACT:R-CFA-6814418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes formation of G-beta:G-gamma heterodimers (Canis familiaris)
REACT:R-SSC-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Sus scrofa)
RHEA:68126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + holo-[ACP] => a 1,2-diacylglycerol + a fatty acyl-[ACP]
REACT:R-DRE-9650165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers bind H+ (Danio rerio)
RHEA:15758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine + NAD(+) => H(+) + L-aspartate 4-semialdehyde + NADH
REACT:R-MMU-380455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CDK11p58 to the centrosomes (Mus musculus)
REACT:R-DDI-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Dictyostelium discoideum)
RHEA:42945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(40) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
REACT:R-PFA-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Plasmodium falciparum)
REACT:R-BTA-5676591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Bos taurus)
REACT:R-HSA-1793176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DS is cleaved from its proteoglycan (Homo sapiens)
REACT:R-HSA-5635846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind GLI1 gene (Homo sapiens)
RHEA:44132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(4)-bis(aminopropyl)spermidine synthase"
RHEA:44132	skos:prefLabel	"N(4)-bis(aminopropyl)spermidine synthase"
RHEA:44132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine
REACT:R-DME-2090038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses heparan chain(2) (Drosophila melanogaster)
RHEA:41564	skos:prefLabel	"aklavinone 7-L-rhodosaminyltransferase"
RHEA:41564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aklavinone 7-L-rhodosaminyltransferase"
RHEA:41564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklavinone + dTDP-beta-L-rhodosamine = aclacinomycin T + dTDP + 2 H(+)
REACT:R-CFA-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Canis familiaris)
RHEA:60965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP
REACT:R-DDI-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Dictyostelium discoideum)
REACT:R-DDI-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Dictyostelium discoideum)
REACT:R-DME-1638053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)
RHEA:28532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + xanthosine => H2O + XMP
REACT:R-DRE-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Danio rerio)
RHEA:61431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-trans-nepetalactol + NAD(+) <=> cis-trans-nepetalactone + H(+) + NADH
REACT:R-RNO-9023626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)
REACT:R-BTA-139855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X1-mediated entry of Ca++ from plasma (Bos taurus)
REACT:R-HSA-909780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine (Homo sapiens)
REACT:R-HSA-9013361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEXT3 is cleaved to produce NICD3 (Homo sapiens)
GO:0018519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-ethylbenzene glycol dehydrogenase activity
GO:0018519	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity
GO:0018519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-dihydroethylcatechol dehydrogenase activity
RHEA:72076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine => ADP + H(+) + ophthalmate + phosphate
RHEA:48304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
RHEA:53126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-carotene => all-trans-lycopene
RHEA:36898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O
REACT:R-CEL-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Caenorhabditis elegans)
RHEA:41766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GT3 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E))
REACT:R-CFA-749446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Canis familiaris)
REACT:R-DME-5368580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Drosophila melanogaster)
GO:0050473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonate omega6 lipoxygenase activity
GO:0050473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	15-lipoxygenase activity
GO:0050473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonate:oxygen 15-oxidoreductase activity
GO:0050473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonate 15-lipoxygenase activity
GO:0050473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	omega6 lipoxygenase activity
GO:0050473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleic acid omega6-lipoxygenase activity
GO:0050473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonate omega(6) lipoxygenase activity
RHEA:39848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + ATP => a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)
RHEA:37559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-DRE-8948232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Danio rerio)
REACT:R-HSA-9697085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNAP transcribes Mtb RNA polyanion (Homo sapiens)
GO:0050217	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-3-hexanone propanal-lyase activity
GO:0050217	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-3-hexanone aldolase activity
GO:0050217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propioin synthase activity
GO:0050217	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-3-hexanone propanal-lyase (propanal-forming)
RHEA:68994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2,4-dihydroxybenzoate + H2O + NADP(+) => 3-amino-4-hydroxybenzoate + H(+) + NADPH + O2
REACT:R-DRE-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Danio rerio)
REACT:R-MMU-5649673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyA from damaged DNA (Mus musculus)
RHEA:72660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + quinolin-8-ol => 8-hydroxyquinoline N-oxide + H2O + NADP(+)
REACT:R-MMU-1234177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
RHEA:39197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetracosanoyl-CoA + NADP(+) => 3-oxotetracosanoyl-CoA + H(+) + NADPH
EC:3.1.26.1	skos:prefLabel	"Physarum polycephalum ribonuclease"
EC:3.1.26.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Physarum polycephalum ribonuclease"
EC:1.14.19.4	skos:prefLabel	"acyl-lipid (11-3)-desaturase"
EC:1.14.19.4	skos:altLabel	"Delta(8)-desaturase"
EC:1.14.19.4	skos:altLabel	"SLD"
EC:1.14.19.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid (11-3)-desaturase"
EC:1.14.19.4	skos:altLabel	"acyl-lipid 8-desaturase"
RHEA:23413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylputrescine => acetate + putrescine
RHEA:29022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(in) + H(+)(in) <=> D-galactose(out) + H(+)(out)
REACT:R-MMU-4551738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO2,3 (Mus musculus)
RHEA:27460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-iodo-L-tyrosine + iodide + NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + NADPH
RHEA:70101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	penilactone A => H(+) + o-quinone methide + peniphenone D
RHEA:58467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP
REACT:R-DME-5655466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Drosophila melanogaster)
RHEA:24152	skos:altLabel	"APS kinase"
RHEA:24152	skos:altLabel	"adenylylsulfate kinase"
RHEA:24152	skos:prefLabel	"adenylyl-sulfate kinase"
RHEA:24152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylyl-sulfate kinase"
RHEA:24152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)
RHEA:24152	skos:altLabel	"adenosine 5'-phosphosulfate kinase"
REACT:R-GGA-983285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B binds RAD51C (Gallus gallus)
REACT:R-BTA-9749986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Bos taurus)
RHEA:49228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacteriochlorophyll a synthase"
RHEA:49228	skos:prefLabel	"bacteriochlorophyll a synthase"
RHEA:49228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) = diphosphate + geranylgeranyl-bacteriochlorophyllide a
RHEA:31134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide
REACT:R-BTA-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Bos taurus)
REACT:R-RNO-8953339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNPH1 hydrolyses dGMP (Rattus norvegicus)
REACT:R-CFA-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Canis familiaris)
REACT:R-DRE-983421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Journey of cargo through Golgi complex (Danio rerio)
REACT:R-HSA-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Homo sapiens)
REACT:R-DME-204861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shc1 (Drosophila melanogaster)
RHEA:58564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine + NADP(+) = 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH
RHEA:50334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:36157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + Co-precorrin-4 + S-adenosyl-L-homocysteine => AH2 + Co(II)-factor III + S-adenosyl-L-methionine
REACT:R-CEL-9635739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 dephosphorylates p-T,Y-MAPKs (Caenorhabditis elegans)
REACT:R-MMU-174456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments of the C-strand (Mus musculus)
GO:0072542	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 1 activator activity
GO:0072542	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase 2 activator activity
GO:0072542	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 2A activator activity
GO:0072542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphatase activator activity
REACT:R-CFA-5621353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Canis familiaris)
REACT:R-MMU-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Mus musculus)
REACT:R-RNO-8955285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)
REACT:R-XTR-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Xenopus tropicalis)
RHEA:32844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol
RHEA:31980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + trimethylamine => H2O + NADP(+) + trimethylamine N-oxide
REACT:R-DRE-469659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A1 dehydrogenates TEST to DHTEST (Danio rerio)
RHEA:14908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine
REACT:R-CFA-9668902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18-RFC(7s) complex (Canis familiaris)
RHEA:46467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-418576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 1:Gq complex (Sus scrofa)
REACT:R-BTA-8864307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Bos taurus)
RHEA:17398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + NADP(+) => a 3-oxoacyl-[ACP] + H(+) + NADPH
REACT:R-GGA-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Gallus gallus)
REACT:R-HSA-1655851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2P hydrolyzes SREBP1A,1C,2 (Homo sapiens)
RHEA:65348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA = 3-oxochol-4,6-dien-24-oyl-CoA + H2O
RHEA:34377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanoate + NH4(+) => 4-guanidinobutanamide + H2O
REACT:R-HSA-9727857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL (Homo sapiens)
REACT:R-RNO-6799197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Rattus norvegicus)
REACT:R-DRE-183126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to surface-associated C3b (Danio rerio)
REACT:R-RNO-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Rattus norvegicus)
REACT:R-XTR-6784676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Xenopus tropicalis)
REACT:R-BTA-9607304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Bos taurus)
REACT:R-BTA-1250380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Bos taurus)
REACT:R-MMU-1168445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B binds the GH receptor complex (Mus musculus)
REACT:R-XTR-2454081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5 oxidises 11cROL to 11cRAL (Xenopus tropicalis)
REACT:R-SPO-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Schizosaccharomyces pombe)
REACT:R-HSA-8864029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Homo sapiens)
RHEA:72689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol(in) => all-trans-retinol(out)
RHEA:39082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydodecanedioyl-CoA + NAD(+) <=> 3-oxododecanedioyl-CoA + H(+) + NADH
REACT:R-SSC-448603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33:IL1RL1 binds IL1RAP-1 (Sus scrofa)
REACT:R-DRE-190388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3c (Danio rerio)
REACT:R-GGA-1977958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with ERBB3 (Gallus gallus)
RHEA:14090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + glycine => glyoxylate + L-glutamate
RHEA:35169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	minocycline(out) => minocycline(in)
RHEA:16564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + squalene <=> hopan-22-ol
REACT:R-DDI-6811412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer to the Golgi (Dictyostelium discoideum)
REACT:R-MMU-9021520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds WWP2 (Mus musculus)
RHEA:29689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + alpha-maltohexaose => alpha-maltoheptaose + phosphate
RHEA:12832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-methyl-L-aspartate <=> mesaconate + NH4(+)
RHEA:57172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH
RHEA:59834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => ATP + N(6)-(D-fructosyl)-L-lysyl-[protein]
REACT:R-XTR-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Xenopus tropicalis)
REACT:R-RNO-72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of eIF4E from the inactive eIF4E:4E-BP complex  (Rattus norvegicus)
RHEA:69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH
REACT:R-SCE-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-MMU-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Mus musculus)
REACT:R-SSC-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Sus scrofa)
REACT:R-DDI-2993780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO1 from E1 to UBE2I (UBC9) (Dictyostelium discoideum)
RHEA:27377	skos:prefLabel	"glycerate 2-kinase"
RHEA:27377	skos:altLabel	"D-glycerate-2-kinase"
RHEA:27377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerate 2-kinase"
RHEA:27377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + ATP = (2R)-2-phosphoglycerate + ADP + H(+)
REACT:R-RNO-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)
RHEA:27295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-GGA-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Gallus gallus)
GO:0140376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	innate immune receptor activity
REACT:R-SSC-9726875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCNs:cAMP bind SNIs (Sus scrofa)
RHEA:33889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-matairesinol + 2 H(+) + 2 NADH => (-)-secoisolariciresinol + 2 NAD(+)
REACT:R-DME-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Drosophila melanogaster)
REACT:R-CFA-9708457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HM13 cleaves HMOX1 dimer (Canis familiaris)
REACT:R-XTR-5683930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WICH phosphorylates H2AFX on Y142 (Xenopus tropicalis)
REACT:R-XTR-8964284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in active Gq-BTK complex is activated (Xenopus tropicalis)
RHEA:52334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin] => 2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin]
RHEA:16775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + H(+) + UDP => ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose
REACT:R-RNO-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Rattus norvegicus)
REACT:R-MMU-2046239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular KSPG translocates to the lysosome for degradation (Mus musculus)
RHEA:29217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-8 + succinate => fumarate + menaquinol-8
REACT:R-CEL-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Caenorhabditis elegans)
REACT:R-MMU-6809010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating (Mus musculus)
REACT:R-RNO-9733964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Rattus norvegicus)
RHEA:59316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose + O2 = D-cellobiono-1,5-lactone + H2O2
RHEA:34579	skos:prefLabel	"pentalenolactone F synthase"
RHEA:34579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pentalenolactone F synthase"
RHEA:34579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + 2 O2 + pentalenolactone D = 2 CO2 + H2O + pentalenolactone F + 2 succinate
RHEA:72294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dimethylsuccinate(out) + 3 Na(+)(out) <=> 2,3-dimethylsuccinate(in) + 3 Na(+)(in)
REACT:R-MMU-6805792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S291-PHF20 translocates to cytosol (Mus musculus)
REACT:R-SSC-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Sus scrofa)
RHEA:13313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sarcosine oxidasee (formaldehyde-forming)"
RHEA:13313	skos:altLabel	"sarcosine oxidasee"
RHEA:13313	skos:prefLabel	"sarcosine oxidasee (formaldehyde-forming)"
RHEA:13313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + sarcosine = formaldehyde + glycine + H2O2
RHEA:13313	skos:altLabel	"monomeric sarcosine oxidase"
RHEA:13313	skos:altLabel	"MSOX"
REACT:R-DME-165129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP is exchanged for GTP on DRheb (Drosophila melanogaster)
REACT:R-PFA-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Plasmodium falciparum)
RHEA:18087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine => coenzyme B + coenzyme M + methanophenazine
RHEA:35572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Dictyostelium discoideum)
REACT:R-HSA-2485111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP10 (Homo sapiens)
REACT:R-DRE-5607747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MALT1 oligomers (Danio rerio)
REACT:R-SSC-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Sus scrofa)
RHEA:22539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine
REACT:R-GGA-382052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130Cas and C3G bind PDGFR bound Crk (Gallus gallus)
REACT:R-PFA-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Plasmodium falciparum)
RHEA:18508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)
REACT:R-HSA-9686005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)
REACT:R-GGA-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Gallus gallus)
REACT:R-GGA-2161282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastic fibres bind associated proteins (Gallus gallus)
REACT:R-MMU-77338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Mus musculus)
REACT:R-BTA-9034053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Bos taurus)
REACT:R-HSA-4420153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds PLCG1 (Homo sapiens)
REACT:R-RNO-2168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds DLL4 (Rattus norvegicus)
REACT:R-HSA-9708812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1) (Homo sapiens)
RHEA:47995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + NAD(+) + NADPH <=> H(+)(out) + NADH + NADP(+)
RHEA:22577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-homoserine lactone + H2O => an N-acyl-L-homoserine + H(+)
RHEA:37140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
RHEA:11529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate
RHEA:66474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-episcalar-17(25)-en-19-ol => (2Z,6E,10E,14E)-geranylfarnesol
REACT:R-BTA-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Bos taurus)
GO:0050193	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylulose-5-phosphate phosphoketolase activity
GO:0050193	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)
GO:0050193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoketolase activity
GO:0050193	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity
RHEA:70871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-valine(out) + Na(+)(out) = L-glutamine(out) + L-valine(in) + Na(+)(in)
REACT:R-CFA-4084999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU1 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)
REACT:R-XTR-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Xenopus tropicalis)
RHEA:42809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) => 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite
RHEA:51479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + formate + H(+) <=> a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O
REACT:R-DRE-936986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains (Danio rerio)
REACT:R-HSA-5626223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
RHEA:30745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose + H(+) + nicotinamide => beta-nicotinamide D-riboside + H2O
RHEA:49364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) = 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate
REACT:R-MMU-390846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2D3,4 bind to DA (Mus musculus)
GO:0102478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-arabinofuranosidase activity
REACT:R-HSA-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Homo sapiens)
REACT:R-BTA-1604741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP14 (MT1-MMP) (Bos taurus)
REACT:R-MMU-508308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Mus musculus)
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PI 4-kinase activity
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PI4-kinase activity
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PI4K
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylinositol kinase (phosphorylating) activity
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PtdIns-4-kinase activity
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol 4-kinase activity
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II phosphatidylinositol kinase activity
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PI kinase activity
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylinositol 4-kinase activity
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PI4K-alpha activity
GO:0004430	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylinositol kinase activity
REACT:R-RNO-201634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of FADK 1 (Rattus norvegicus)
RHEA:27887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-AMP + H2O => 3'-AMP + H(+)
REACT:R-XTR-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Xenopus tropicalis)
RHEA:11583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + myo-inositol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)
REACT:R-RNO-5696365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Rattus norvegicus)
RHEA:51409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
RHEA:23229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NADPH + O2 => H2O + N(6)-hydroxy-L-lysine + NADP(+)
REACT:R-SSC-9718394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide antagonists (Sus scrofa)
REACT:R-DRE-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Danio rerio)
REACT:R-DDI-2066780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Dictyostelium discoideum)
REACT:R-XTR-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Xenopus tropicalis)
RHEA:19968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S,S-dimethyl-beta-propiothetin <=> acrylate + dimethyl sulfide + H(+)
RHEA:56806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]
RHEA:58880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:13898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate => prephenate
REACT:R-CFA-201630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Acinus (Canis familiaris)
REACT:R-DRE-9679775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT binds COMT Inhibitors (Danio rerio)
REACT:R-SSC-2395223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyridinoline cross-links (Sus scrofa)
GO:0005135	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-3 receptor ligand
GO:0005135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-3 receptor binding
GO:0005135	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-3
REACT:R-DRE-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Danio rerio)
REACT:R-GGA-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Gallus gallus)
REACT:R-RNO-9750946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)
REACT:R-BTA-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Bos taurus)
REACT:R-DME-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Drosophila melanogaster)
GO:0102379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolbioside glucosyltransferase activity (stevioside forming)
RHEA:43212	skos:altLabel	"thiostrepton-resistance methylase"
RHEA:43212	skos:prefLabel	"23S rRNA (adenosine(1067)-2'-O)-methyltransferase"
RHEA:43212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (adenosine(1067)-2'-O)-methyltransferase"
RHEA:43212	skos:altLabel	"nosiheptide-resistance methyltransferase"
RHEA:43212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:43212	skos:altLabel	"23S rRNA A(1067) 2'-methyltransferase"
REACT:R-DRE-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Danio rerio)
RHEA:56845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocamycin E + S-adenosyl-L-methionine => nocamycin I + S-adenosyl-L-homocysteine
REACT:R-PFA-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Plasmodium falciparum)
RHEA:68068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-androstane-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH
REACT:R-CEL-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Caenorhabditis elegans)
RHEA:34546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP
REACT:R-MMU-4085372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO2,3 (Mus musculus)
RHEA:13290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP
REACT:R-MMU-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Mus musculus)
RHEA:41079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:35092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine => 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine
RHEA:36594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-chloropropanoate + NADP(+) <=> 2-chloroacrylate + H(+) + NADPH
REACT:R-HSA-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Homo sapiens)
RHEA:29702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide(in) <=> dimethyl sulfoxide(out)
RHEA:65851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-Delta(1)-steroid + H2O <=> a steroid 1,3-dione + AH2
REACT:R-BTA-6806831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5Rs reduce MetHb to HbA (Bos taurus)
RHEA:31694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> (9R)-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-DDI-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Dictyostelium discoideum)
REACT:R-MMU-217258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO2:FAD:Mg2+ S-oxidises MTZ (Mus musculus)
RHEA:50982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E1(in) => prostaglandin E1(out)
RHEA:37550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + NAD(+) <=> 3-dehydro-D-glucose 6-phosphate + H(+) + NADH
REACT:R-SSC-1306957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)
RHEA:55859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-399936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of integrin activation by sequestering PIP5KIgamma (Sus scrofa)
RHEA:29460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(in) + H(+)(in) => beta-alanine(out) + H(+)(out)
REACT:R-HSA-5657637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA (Homo sapiens)
REACT:R-DRE-194718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Danio rerio)
REACT:R-HSA-8863804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Homo sapiens)
REACT:R-DRE-9646679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded proteins bind vimentin to form aggresome (Danio rerio)
RHEA:31917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-maltose 1-phosphate + H(+) => ATP + D-maltose
RHEA:52099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-octadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + octadecanoate
RHEA:40656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate + succinyl-CoA => (R)-malyl-CoA + succinate
RHEA:33918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(methylamino)butanoate + H2O + O2 <=> H2O2 + methylamine + succinate semialdehyde
REACT:R-CEL-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Caenorhabditis elegans)
REACT:R-MMU-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Mus musculus)
REACT:R-SSC-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Sus scrofa)
REACT:R-HSA-159001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
REACT:R-HSA-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
REACT:R-DRE-211190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of DFF45 (117) (Danio rerio)
REACT:R-HSA-9617209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB gene transcription is enhanced by phospho-CREB1 and phospho-STAT3 (Homo sapiens)
REACT:R-CEL-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Caenorhabditis elegans)
RHEA:65399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dATP + H2O <=> 8-oxo-dAMP + diphosphate + H(+)
REACT:R-BTA-8849094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RASA1 (Bos taurus)
REACT:R-CFA-8948775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKRN1 polyubiquitinates PTEN (Canis familiaris)
REACT:R-CFA-8850992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated PTEN (Canis familiaris)
RHEA:27508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + ecgonine methyl ester + H(+) => cocaine + H2O
REACT:R-SSC-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Sus scrofa)
RHEA:48178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein] => decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-HSA-8948015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Homo sapiens)
REACT:R-HSA-2872463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9C1 exchanges Na+ for H+ (Homo sapiens)
REACT:R-MMU-6786048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Mus musculus)
RHEA:14055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate => D-arabinose 5-phosphate + H2O + phosphoenolpyruvate
RHEA:19212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	codeine + NADP(+) <=> codeinone + H(+) + NADPH
REACT:R-DRE-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Danio rerio)
REACT:R-CEL-193491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Caenorhabditis elegans)
REACT:R-CFA-159567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform ST to ST-CoA (Canis familiaris)
REACT:R-CFA-158747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Canis familiaris)
REACT:R-CFA-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Canis familiaris)
RHEA:64295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH <=> (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)
REACT:R-CFA-606349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mis18 complex binds the centromere (Canis familiaris)
REACT:R-DRE-5419273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of GTP and dissociation of 28S and 39S subunits (Danio rerio)
REACT:R-XTR-3828025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP14 (Xenopus tropicalis)
REACT:R-MMU-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Mus musculus)
RHEA:23807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosamine 1-phosphate <=> N-acetyl-D-glucosamine 6-phosphate
RHEA:43851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + arsenate + H(+) <=> [thioredoxin]-disulfide + arsenite + H2O
REACT:R-BTA-5696465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP45 deubiquitinates ERCC1 (Bos taurus)
RHEA:29179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 2 O2 = a menaquinone + 2 H(+) + 2 superoxide
REACT:R-BTA-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Bos taurus)
RHEA:23513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + phosphate => beta-D-glucose 1-phosphate + D-glucose
REACT:R-MMU-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Mus musculus)
GO:0005363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose(in) = D-maltose(out)
GO:0005363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose transmembrane transporter activity
GO:0005363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose porter activity
REACT:R-GGA-205234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of GAB2 to p-KIT (Gallus gallus)
REACT:R-CFA-2029453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of VAV (Canis familiaris)
RHEA:32620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin
REACT:R-SSC-5660980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S276-RELA binds RELB (Sus scrofa)
RHEA:60570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-tryptophan => N-acetyl-L-tryptophan
REACT:R-BTA-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Bos taurus)
RHEA:30509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + NAD(+) => 2-demethylmenaquinone-8 + H(+) + NADH
RHEA:65185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + preaustinoid A1 => berkeleyone B + CO2 + H2O + succinate
REACT:R-XTR-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Xenopus tropicalis)
REACT:R-CFA-909720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN alpha/beta binds to IFNAR2 (Canis familiaris)
REACT:R-CEL-3814820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Caenorhabditis elegans)
REACT:R-CFA-203130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OLR1 binds to oxidized LDL (Canis familiaris)
REACT:R-CFA-9692539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds HRH1 inverse agonists (Canis familiaris)
REACT:R-CEL-8938867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND3,(CCND1,CCND2) binds RUNX1 (Caenorhabditis elegans)
REACT:R-RNO-114577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)
RHEA:43719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate <=> [glutamine synthetase]-L-tyrosine + ADP
RHEA:63795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate
RHEA:64560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-ol + NAD(+) = butan-2-one + H(+) + NADH
REACT:R-CFA-416559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)
REACT:R-DME-209178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-HH binds to PTC receptor complex (Drosophila melanogaster)
REACT:R-CEL-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Caenorhabditis elegans)
REACT:R-HSA-3858495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits GTP-bound RHOA (Homo sapiens)
REACT:R-RNO-158218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Rattus norvegicus)
REACT:R-BTA-9014449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the plasma membrane (Bos taurus)
REACT:R-XTR-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Xenopus tropicalis)
RHEA:69637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:31974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 <=> 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)
RHEA:65402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyl butanoate + CoA => butan-1-ol + butanoyl-CoA
REACT:R-PFA-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Plasmodium falciparum)
RHEA:49135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Danio rerio)
RHEA:51890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5,6-tetrachloro-1,4-benzoquinone + NADH => 2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+)
REACT:R-SSC-141026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor Va to factor Vi intermediate form (Sus scrofa)
RHEA:42381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O => 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)
GO:0033779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity
GO:0033779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P450 8B1
GO:0033779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity
GO:0033779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity
GO:0033779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP8B1
GO:0033779	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sterol 12alpha-hydroxylase activity
RHEA:13284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) <=> 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH
GO:0047705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bilirubin:oxygen oxidoreductase activity
GO:0047705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bilirubin oxidase M-1
GO:0047705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin oxidase activity
REACT:R-MMU-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Mus musculus)
REACT:R-RNO-5654641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
REACT:R-XTR-397891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:G12/13 (active) dissociate (Xenopus tropicalis)
RHEA:28756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + sn-glycerol 3-phosphate => a ubiquinol + dihydroxyacetone phosphate
REACT:R-BTA-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Bos taurus)
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid D-isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta5-3-oxosteroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta5-3-keto steroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(5)-3-oxosteroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta5-3-ketosteroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(5)-steroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(5)-3-keto steroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxosteroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta5(or delta4)-3-keto steroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta5-ketosteroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta5-steroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid delta-isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxysteroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxosteroid delta5-delta4-isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(5)-3-ketosteroid isomerase activity
GO:0004769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid isomerase activity
RHEA:69955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)
RHEA:12492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine = D-methionine
RHEA:12492	skos:prefLabel	"methionine racemase"
RHEA:12492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionine racemase"
REACT:R-MMU-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Mus musculus)
RHEA:10452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]
RHEA:60867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-622382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Homo sapiens)
REACT:R-GGA-6785342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Gallus gallus)
GO:0004121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta C-S lyase activity
GO:0004121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cystine lyase activity
GO:0004121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cystathionase activity
GO:0004121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cystathionine beta-lyase activity
GO:0004121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)
GO:0004121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cystathionine L-homocysteine-lyase (deaminating)
GO:0004121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cystathionine L-homocysteine-lyase (deaminating)
REACT:R-SSC-983421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Journey of cargo through Golgi complex (Sus scrofa)
REACT:R-RNO-5099899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD4 (Rattus norvegicus)
REACT:R-RNO-1855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Rattus norvegicus)
RHEA:38991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)
REACT:R-XTR-879907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate the receptor (Xenopus tropicalis)
REACT:R-HSA-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Homo sapiens)
REACT:R-MMU-193737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Mus musculus)
RHEA:62887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 4 semiviriditoxin <=> 2 (M)-viriditoxin + 2 H2O
RHEA:42832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H(+) + pyruvate = (S)-3-acetyloctanal + CO2
RHEA:42832	skos:prefLabel	"3-acetyloctanal synthase"
RHEA:42832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-acetyloctanal synthase"
RHEA:32992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
RHEA:21811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopiperazine + H2O <=> glycylglycine
RHEA:30195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,9'-di-cis-phytofluene + plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + plastoquinol-9
RHEA:38620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate beta-D-ribonucleotide + phenol => H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside
REACT:R-CFA-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Canis familiaris)
RHEA:46292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate
REACT:R-DRE-5357429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL autophosphorylates on Y772 and Y814 (Danio rerio)
REACT:R-BTA-6784676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)
RHEA:72613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanyl-L-lysine(in) => H(+)(out) + L-alanyl-L-lysine(out)
RHEA:71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) + L-phenylalanine(out) <=> L-alanine(out) + L-phenylalanine(in)
RHEA:18383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + pyruvate => dihydroxyacetone + phosphoenolpyruvate
RHEA:33624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + dodecanoate => AMP + diphosphate + dodecanoyl-CoA
REACT:R-BTA-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Bos taurus)
GO:0043822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease M5 activity
GO:0043822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5S ribosomal maturation nuclease activity
GO:0043822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase M5 activity
GO:0043822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S ribosomal RNA maturation endonuclease activity
RHEA:21185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + GDP-alpha-D-mannose => a dolichyl beta-D-mannosyl phosphate + GDP
RHEA:63882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur => 2 Fe(III)-[cytochrome c] + H2O + thiocyanate
REACT:R-HSA-9615536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 and SOX2 bind MIR137 gene (Homo sapiens)
REACT:R-MMU-434989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA7A binds to PLXNC1 (Mus musculus)
RHEA:68273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + L-seryl-[protein] => CoA + O-fatty acyl-L-seryl-[protein]
REACT:R-DDI-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Dictyostelium discoideum)
REACT:R-DRE-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Danio rerio)
REACT:R-GGA-434058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96 (Gallus gallus)
REACT:R-RNO-159179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)
RHEA:12774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + proclavaminate => CO2 + dihydroclavaminate + H2O + succinate
RHEA:38954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sphing-4-enine 1-phosphate(in) <=> ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)
REACT:R-MMU-9647999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCE1 cleaves S-Farn proRAS proteins (Mus musculus)
GO:0016406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine O-acyltransferase activity
REACT:R-SSC-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Sus scrofa)
REACT:R-DME-179467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)
GO:0015165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine nucleotide-sugar transmembrane transporter activity
RHEA:10630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + tRNA(n) => phosphate + tRNA(n+1)
REACT:R-HSA-9694455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)
REACT:R-SSC-5696534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 deubiquitinates TAK1:TAB1 (Sus scrofa)
RHEA:67963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-L-phenylalanine + S-adenosyl-L-methionine <=> 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine
RHEA:11378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,21-dehydrogeissoschizine + NADPH => (19E)-geissoschizine + NADP(+)
REACT:R-BTA-2429719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCPH1 sequesters condensin II (Bos taurus)
REACT:R-XTR-6814675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Xenopus tropicalis)
RHEA:32358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + 2 UDP
REACT:R-SCE-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Saccharomyces cerevisiae)
GO:0047860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aromatic alpha-keto acid
GO:0047860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diiodophenylpyruvate reductase activity
GO:0047860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KAR
GO:0047860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity
GO:0047860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo acid reductase activity
REACT:R-RNO-5617143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)
RHEA:46858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH
RHEA:43862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in)
RHEA:17967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+)
REACT:R-RNO-382553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA7:Apo1A-mediated phospholipid efflux (Rattus norvegicus)
RHEA:72103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-propanoyl-(R)-carnitine(out) = Na(+)(in) + O-propanoyl-(R)-carnitine(in)
RHEA:62898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose
REACT:R-XTR-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Xenopus tropicalis)
RHEA:54382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:10705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-valine + tRNA(Val) => AMP + diphosphate + L-valyl-tRNA(Val)
RHEA:27564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 7 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 7 diphosphate
REACT:R-GGA-2029459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Gallus gallus)
REACT:R-BTA-74746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y427-SHC1 (Bos taurus)
REACT:R-CFA-8869425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA1A hydrolyses PS to 2-acyl LPS (Canis familiaris)
REACT:R-DRE-9634702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Danio rerio)
RHEA:47641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine
REACT:R-MMU-8849157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Mus musculus)
RHEA:25142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) <=> 3-amino-2-oxopropyl phosphate + CO2
REACT:R-SSC-211923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26C1 4-hydroxylates 9cRA (Sus scrofa)
REACT:R-HSA-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Homo sapiens)
REACT:R-BTA-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Bos taurus)
REACT:R-CFA-352268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Satb1 (Canis familiaris)
RHEA:53177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)
REACT:R-XTR-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Xenopus tropicalis)
RHEA:16795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + CO2 => H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
RHEA:38321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate => chorismate + H2O
RHEA:25058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) + NADH + O2 = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)
REACT:R-CFA-6809010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating (Canis familiaris)
RHEA:43663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + propanoyl-CoA <=> ADP + H(+) + methylmalonyl-CoA + phosphate
REACT:R-BTA-6784323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Bos taurus)
REACT:R-RNO-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Rattus norvegicus)
REACT:R-HSA-5676598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:cIAP1/2 complex binds FN14:TWEAK (Homo sapiens)
REACT:R-CFA-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Canis familiaris)
RHEA:11606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA
REACT:R-DDI-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Dictyostelium discoideum)
RHEA:28166	skos:altLabel	"5NAA deaminase"
RHEA:28166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-nitroanthranilate + H(+) + H2O = 5-nitrosalicylate + NH4(+)
RHEA:28166	skos:prefLabel	"5-nitroanthranilic acid aminohydrolase"
RHEA:28166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-nitroanthranilic acid aminohydrolase"
RHEA:70372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + decanoyl-CoA => CoA + H(+) + N-decanoyl-3-oxosphinganine
RHEA:61619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-proline betaine + NADH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NAD(+)
RHEA:53575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Dictyostelium discoideum)
REACT:R-BTA-3371467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates HSF1 (Bos taurus)
REACT:R-XTR-77340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Xenopus tropicalis)
RHEA:27293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + formate + H(+) <=> AH2 + CO2
RHEA:11033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate => 3-chloro-cis,cis-muconate + H(+)
RHEA:19094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + siroheme => 12,18-didecarboxysiroheme + 2 CO2
RHEA:58488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate + H(+) + NADH + O2 = H2O + NAD(+) + succinate semialdehyde + trimethylamine
REACT:R-HSA-9705729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)
REACT:R-DRE-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Danio rerio)
REACT:R-HSA-1250315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB4 homodimers (Homo sapiens)
RHEA:49600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + octanedioate = AMP + diphosphate + octanedioyl-CoA
REACT:R-MMU-9013024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors at the plasma membrane (Mus musculus)
RHEA:60719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemal + H2O + NADP(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADPH
REACT:R-DME-2395965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)
REACT:R-DME-5423653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGST trimers transfer GS from GSH to AFXBO and AFNBO (Drosophila melanogaster)
GO:0015104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	antimonite transmembrane transporter activity
RHEA:33083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclic dehypoxanthinyl futalosine synthase"
RHEA:33083	skos:altLabel	"dehypoxanthinyl futalosine cyclase"
RHEA:33083	skos:prefLabel	"cyclic dehypoxanthinyl futalosine synthase"
RHEA:33083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine
REACT:R-DRE-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Danio rerio)
REACT:R-DRE-2393954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
RHEA:21264	skos:prefLabel	"glycolate dehydrogenase"
RHEA:21264	skos:altLabel	"glycolate oxidoreductase"
RHEA:21264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycolate dehydrogenase"
RHEA:21264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + glycolate = AH2 + glyoxylate
RHEA:21264	skos:altLabel	"glycolic acid dehydrogenase"
REACT:R-GGA-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Gallus gallus)
RHEA:63211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + glyoxal <=> 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O
RHEA:63765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine
RHEA:39811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP
REACT:R-MMU-1067640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R-2 (Mus musculus)
REACT:R-GGA-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Gallus gallus)
GO:0052623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:ADP dimethylallyltransferase activity
GO:0052623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP isopentenyltransferase activity
GO:0052623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP dimethylallyltransferase activity
GO:0052623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopentenyl-diphosphate:ADP delta2-isopentenyltransferase activity
GO:0052623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopentenyl-diphosphate:ADP 2-isopentenyltransferase activity
REACT:R-GGA-5694421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6 dephosphorylates SEC24 (Gallus gallus)
REACT:R-DRE-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Danio rerio)
REACT:R-XTR-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Xenopus tropicalis)
REACT:R-HSA-169891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS:Crk complex binds to active TrkA receptor (Homo sapiens)
RHEA:14885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein]
REACT:R-BTA-2993898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRK1/VRK2 phosphorylate BANF1 (Bos taurus)
REACT:R-DRE-9026005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Danio rerio)
REACT:R-DME-3322019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-b (Drosophila melanogaster)
REACT:R-CFA-8854052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the SCF-FBXL7 complex (Canis familiaris)
RHEA:51605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9023884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to TGFA promoter (Homo sapiens)
REACT:R-BTA-9634846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNTL (BMAL1) (Bos taurus)
REACT:R-MMU-8953461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Mus musculus)
REACT:R-RNO-6814409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates PDCL (Rattus norvegicus)
REACT:R-SSC-76373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxylation of 4-aminobiphenyl (Sus scrofa)
REACT:R-HSA-446209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of N-glycan to the protein (Homo sapiens)
RHEA:12905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannose-1-phosphate guanylyltransferase (GDP)"
RHEA:12905	skos:altLabel	"GDP-mannose phosphorylase"
RHEA:12905	skos:prefLabel	"mannose-1-phosphate guanylyltransferase (GDP)"
RHEA:12905	skos:altLabel	"GDP-mannose pyrophosphorylase"
RHEA:12905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate
REACT:R-BTA-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
RHEA:66241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + IC-asc-C9 => AMP + diphosphate + IC-asc-C9-CoA
RHEA:15573	skos:prefLabel	"acetylserotonin O-methyltransferase"
RHEA:15573	skos:altLabel	"hydroxyindole O-methyltransferase"
RHEA:15573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylserotonin O-methyltransferase"
RHEA:15573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine
RHEA:20455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + scopolin + UDP => scopoletin + UDP-alpha-D-glucose
REACT:R-RNO-71010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUT isomerises L-MM-CoA to SUCC-CoA (Rattus norvegicus)
REACT:R-MMU-9025995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Mus musculus)
RHEA:23706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate => GTP + 4 H2O
REACT:R-CFA-5368580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Canis familiaris)
REACT:R-DRE-373339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Danio rerio)
REACT:R-BTA-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)
REACT:R-GGA-382054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binds to extracellular matrix proteins (Gallus gallus)
REACT:R-SCE-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Saccharomyces cerevisiae)
RHEA:54174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+)
RHEA:58745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(7)-methyl-GTP => diphosphate + H(+) + N(7)-methyl-GMP
REACT:R-HSA-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)
RHEA:46415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:58442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine
REACT:R-RNO-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Rattus norvegicus)
REACT:R-HSA-2076371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLCE epimerises more GlcA to IdoA as sulfate content rises (Homo sapiens)
RHEA:56644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in mRNA = a pseudouridine in mRNA
REACT:R-MMU-8848606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates PXN (Mus musculus)
RHEA:45256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate(out) = hexadecanoate(in)
RHEA:23751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP <=> diphosphate + pppGp(2'-5')A
RHEA:54801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) => [nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA
RHEA:47834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + N-acetylneuraminate => ganglioside GD1a + H2O
RHEA:21656	skos:altLabel	"CDP-tyvelose 2-epimerase"
RHEA:21656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-paratose = CDP-3,6-dideoxy-alpha-D-mannose
RHEA:21656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-paratose 2-epimerase"
RHEA:21656	skos:altLabel	"CDP-paratose epimerase"
RHEA:21656	skos:altLabel	"cytidine diphosphate paratose-2-epimerase"
RHEA:21656	skos:altLabel	"cytidine diphosphodideoxyglucose epimerase"
RHEA:21656	skos:prefLabel	"CDP-paratose 2-epimerase"
RHEA:21656	skos:altLabel	"CDP-abequose epimerase"
RHEA:21656	skos:altLabel	"cytidine diphosphoparatose epimerase"
RHEA:21656	skos:altLabel	"cytidine diphosphoabequose epimerase"
RHEA:21656	skos:altLabel	"CDP-D-abequose 2-epimerase"
GO:0070818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoporphyrinogenase activity
GO:0070818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoporphyrinogen oxidase activity
GO:0070818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoporphyrinogen-IX oxidase activity
GO:0070818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoporphyrinogen IX oxidase activity
GO:0035175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-serine kinase activity (H3-S10 specific)
GO:0035175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serine kinase activity (H3-S10 specific)
GO:0035175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H3-S10 specific)
GO:0035175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3S10 kinase activity
GO:0015386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium:proton antiporter activity
GO:0015386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium:hydrogen antiporter activity
GO:0015386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out)
RHEA:14795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + H(+) + NADH => 2-hydroxyadipate + NAD(+)
RHEA:43033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-D-alanine => 2-aminoprop-2-enoate + chloride + H(+)
REACT:R-HSA-9612243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOE gene transcription is stimulated by ERBB4s80 (Homo sapiens)
RHEA:31881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-seco-amyrin => (S)-2,3-epoxysqualene
RHEA:51864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + esculetin = 8-geranylesculetin + diphosphate
RHEA:21204	skos:prefLabel	"phosphatidylcholine--sterol O-acyltransferase"
RHEA:21204	skos:altLabel	"lecithin--cholesterol acyltransferase"
RHEA:21204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylcholine--sterol O-acyltransferase"
RHEA:21204	skos:altLabel	"LCAT"
RHEA:21204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester
RHEA:21204	skos:altLabel	"phospholipid--cholesterol acyltransferase"
REACT:R-RNO-379464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DOPAC to form HVA (Rattus norvegicus)
REACT:R-HSA-5387386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh processing variants are recruited to SEL1:SYVN at the ER membrane (Homo sapiens)
REACT:R-GGA-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
RHEA:72301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(in) + L-glutamate(out) => 3,3',5-triiodo-L-thyronine(out) + L-glutamate(in)
REACT:R-SPO-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Schizosaccharomyces pombe)
RHEA:29475	skos:prefLabel	"(+)-cubenene synthase"
RHEA:29475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-cubenene + diphosphate
RHEA:29475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-cubenene synthase"
RHEA:34582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + 2 O2 + pentalenolactone D <=> 2 CO2 + H2O + pentalenolactone F + 2 succinate
REACT:R-DME-1295622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds CBL (Drosophila melanogaster)
REACT:R-CFA-9654521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin dissociates KRAS4B from the plasma membrane (Canis familiaris)
REACT:R-CFA-173720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7 translocates to the plasma membrane (Canis familiaris)
RHEA:54364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetaldehyde = acetoin
REACT:R-GGA-9611839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β3-agonists bind ADRB3 (Gallus gallus)
REACT:R-DRE-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Danio rerio)
REACT:R-DME-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Drosophila melanogaster)
REACT:R-BTA-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Bos taurus)
RHEA:29985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(out) + H(+)(out) => cytidine(in) + H(+)(in)
REACT:R-CFA-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Canis familiaris)
REACT:R-HSA-76416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Benzene is hydroxylated to phenol (Homo sapiens)
REACT:R-BTA-9724670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds imiquimod (Bos taurus)
REACT:R-DME-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Drosophila melanogaster)
RHEA:67769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:31276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-2-methylpropanoate + NAD(+) => (S)-methylmalonate semialdehyde + H(+) + NADH
RHEA:68647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> alpha-thujene + diphosphate
REACT:R-MMU-5638007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 activates the GTPase activity of ARL3 (Mus musculus)
RHEA:66183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + bilirubin-glucuronoside(in) + H2O <=> ADP + bilirubin-glucuronoside(out) + H(+) + phosphate
REACT:R-XTR-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Xenopus tropicalis)
REACT:R-SSC-5666001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Profilin:G-actin binds MKL1 (Sus scrofa)
REACT:R-SSC-1433542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV1 (Sus scrofa)
RHEA:65984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hnu + previtamin D3 = lumisterol 3
RHEA:54218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2
REACT:R-CEL-9718394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide antagonists (Caenorhabditis elegans)
RHEA:63797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate
REACT:R-XTR-187934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Xenopus tropicalis)
GO:0015390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine-specific nucleoside:sodium symporter activity
RHEA:56652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
REACT:R-HSA-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Homo sapiens)
REACT:R-BTA-3301943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTK1 dimer transfers GS from GSH to CDNB (Bos taurus)
RHEA:13460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) <=> (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2
RHEA:53162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + N-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-2197646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1 (SR-BI, CLA-1) binds ligands (Canis familiaris)
GO:0050510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin glucuronyltransferase II activity
GO:0050510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity
GO:0050510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
GO:0050510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity
RHEA:22069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => (2S)-2-acetolactate + H(+) + NADPH
RHEA:22933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-DDI-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Dictyostelium discoideum)
REACT:R-XTR-5687121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPKAPK5 phosphorylates HSPB1 (Xenopus tropicalis)
REACT:R-DRE-110248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 3-methyladenine by MPG glycosylase  (Danio rerio)
REACT:R-DRE-8985900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Danio rerio)
REACT:R-MMU-109449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Mus musculus)
REACT:R-SCE-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Saccharomyces cerevisiae)
REACT:R-HSA-75126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Homo sapiens)
REACT:R-RNO-74948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates p-RHO to RHO (Rattus norvegicus)
REACT:R-HSA-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Homo sapiens)
REACT:R-DRE-2186607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Danio rerio)
GO:0033266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent choline transmembrane transporter activity
GO:0033266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type choline transporter activity
GO:0033266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline-transporting ATPase activity
GO:0033266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled choline transmembrane transporter activity
GO:0033266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type choline transmembrane transporter activity
REACT:R-SCE-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Saccharomyces cerevisiae)
REACT:R-MMU-6786095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates STAT3,STAT6 (Mus musculus)
RHEA:54439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate
REACT:R-SSC-200396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Creatine transport across the plasma membrane (Sus scrofa)
REACT:R-MMU-5682010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10:ATG12 binds ATG5 (Mus musculus)
RHEA:67416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + NAD(+) = 5alpha-cholest-7-en-3-one + H(+) + NADH
REACT:R-CEL-450620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S193-KSRP binds 14-3-3zeta in the nucleus (Caenorhabditis elegans)
REACT:R-MMU-9007447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 forms the PRC1L4 complex (Mus musculus)
RHEA:41100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:71018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methylputrescine + O2 <=> 4-methylaminobutanal + H2O2 + NH4(+)
REACT:R-SSC-193068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates PREG (Sus scrofa)
GO:0047332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate--serine phosphotransferase activity
GO:0047332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate-L-serine phosphotransferase activity
GO:0047332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphate:L-serine O-phosphotransferase activity
GO:0047332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate-serine phosphotransferase activity
REACT:R-BTA-194642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Bos taurus)
RHEA:24604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theobromine
REACT:R-HSA-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)
REACT:R-DRE-216757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)
REACT:R-GGA-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)
REACT:R-CFA-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Canis familiaris)
REACT:R-RNO-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Rattus norvegicus)
REACT:R-SPO-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Schizosaccharomyces pombe)
RHEA:45662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)
RHEA:31372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine => (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine
GO:0036356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cDPGS activity
GO:0036356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPGS activity
GO:0036356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic 2,3-diphosphoglycerate synthetase activity
RHEA:58110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-lysyl-[protein] => H2O + N(6)-acetyl-L-lysyl-[protein]
REACT:R-CFA-428127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Canis familiaris)
REACT:R-RNO-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Rattus norvegicus)
RHEA:55160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin:CoB-CoM heterodisulfide reductase"
RHEA:55160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:55160	skos:prefLabel	"ferredoxin:CoB-CoM heterodisulfide reductase"
RHEA:70311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
REACT:R-HSA-1655832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) (Homo sapiens)
REACT:R-XTR-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Xenopus tropicalis)
REACT:R-BTA-2187405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 binds phosphorylated SMAD2/3 (Bos taurus)
REACT:R-DRE-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Danio rerio)
RHEA:67667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O <=> 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid
RHEA:60133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate
REACT:R-MMU-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Mus musculus)
RHEA:48436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pentanoate ester = an aliphatic alcohol + H(+) + pentanoate
RHEA:45631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] <=> holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]
RHEA:24574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n+1) + D-fructose => [(1->4)-alpha-D-glucosyl](n) + sucrose
REACT:R-CFA-1307963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Canis familiaris)
REACT:R-XTR-264997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cysteine to cystine in Proinsulin (Xenopus tropicalis)
RHEA:68209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA
REACT:R-DME-5362553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTUM releases Hh-Np:GPC5 from the plasma membrane (Drosophila melanogaster)
REACT:R-BTA-6785178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Bos taurus)
REACT:R-BTA-5696358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREM,CD300 binds lipids (Bos taurus)
REACT:R-DRE-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Danio rerio)
REACT:R-XTR-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Xenopus tropicalis)
REACT:R-SCE-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Saccharomyces cerevisiae)
RHEA:25529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
RHEA:69230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an epithionitrile + sulfate => a (Z)-N-(sulfonatooxy)alkenimidothioate
RHEA:59166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase]
REACT:R-HSA-1471322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins are secreted (Homo sapiens)
RHEA:49844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid + a quinone = (-)-dehydrodiconiferyl acid ketone + a quinol
RHEA:29049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 2 H(+)(out) => a menaquinone + 2 H(+)(in) + H2
RHEA:43146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine => adenosine(22) in tRNA + S-adenosyl-L-methionine
RHEA:54659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalool <=> (2E)-geraniol
RHEA:60112	skos:prefLabel	"(R)-3-(aryl)lactoyl-CoA dehydratase"
RHEA:60112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-(indol-3-yl)lactoyl-CoA = (E)-3-(indol-3-yl)acryloyl-CoA + H2O
RHEA:60112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-3-(aryl)lactoyl-CoA dehydratase"
RHEA:60112	skos:altLabel	"aryllactyl-CoA dehydratase"
RHEA:60112	skos:altLabel	"(R)-phenyllactoyl-CoA dehydratase"
RHEA:18341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,4-lactone + H2O = D-xylonate + H(+)
RHEA:18341	skos:prefLabel	"xylono-1,4-lactonase"
RHEA:18341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylono-1,4-lactonase"
RHEA:59881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + FMNH2 + O2 => 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O
REACT:R-HSA-264976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Homo sapiens)
REACT:R-DDI-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Dictyostelium discoideum)
RHEA:16365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tannase"
RHEA:16365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digallate + H2O = 2 3,4,5-trihydroxybenzoate + H(+)
RHEA:16365	skos:prefLabel	"tannase"
REACT:R-RNO-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Rattus norvegicus)
RHEA:57029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)
REACT:R-RNO-913374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
REACT:R-CFA-158800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Canis familiaris)
REACT:R-MMU-77345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Mus musculus)
RHEA:54961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + dinor-OPDA => AMP + dinor-OPDA-CoA + diphosphate
REACT:R-BTA-5226904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Bos taurus)
REACT:R-DRE-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Danio rerio)
RHEA:36437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate(out) => a 1,2-diacyl-sn-glycero-3-phosphate(in)
REACT:R-RNO-8876868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE1 cleaves EDN1(53-90) (Rattus norvegicus)
REACT:R-CFA-975185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)
REACT:R-SPO-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Schizosaccharomyces pombe)
REACT:R-BTA-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Bos taurus)
REACT:R-GGA-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)
REACT:R-BTA-162836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Bos taurus)
RHEA:12116	skos:altLabel	"hydrogenlyase"
RHEA:12116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2 = AH2
RHEA:12116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrogenase (acceptor)"
RHEA:12116	skos:altLabel	"uptake hydrogenase"
RHEA:12116	skos:altLabel	"hydrogen-lyase"
RHEA:12116	skos:altLabel	"H2 producing hydrogenase"
RHEA:12116	skos:prefLabel	"hydrogenase (acceptor)"
RHEA:35925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-deamino-3''-hydroxykanamycin B + H(+) + UDP => neamine + UDP-alpha-D-glucose
RHEA:37038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminopentanoate + NAD(+) <=> 2-oxopentanoate + H(+) + NADH + NH4(+)
RHEA:23201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-methyl-L-lysine + O2 => formaldehyde + H2O2 + L-lysine
RHEA:55293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(54) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine
RHEA:30041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + CO2 + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2
RHEA:43493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyll a + NADP(+) => chlorophyll b + H(+) + NADPH
REACT:R-HSA-9727305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA8 is translated to protein 8 (Homo sapiens)
RHEA:10086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-cis,cis-muconate + 2 H(+) => 3,4-dihydroxybenzoate + O2
REACT:R-HSA-1295599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 translocates to the plasma membrane (Homo sapiens)
REACT:R-SSC-4093336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
REACT:R-SSC-9617927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO4 binds ATXN3 (Sus scrofa)
RHEA:72864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-cAAG + H2O => G[3'-5']pA[3'-5']pAp[3'] + H(+)
RHEA:69867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in RNA + S-adenosyl-L-methionine = a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-450550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCalpha phosphorylates HuR (Homo sapiens)
REACT:R-SPO-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Schizosaccharomyces pombe)
REACT:R-DME-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Drosophila melanogaster)
RHEA:71694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamate(out) + 2 H(+)(out) <=> glycyl-L-glutamate(in) + 2 H(+)(in)
REACT:R-CFA-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Canis familiaris)
REACT:R-SPO-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Schizosaccharomyces pombe)
REACT:R-RNO-381545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the IGF:IGFBP5:ALS complex (Rattus norvegicus)
REACT:R-SSC-8851679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR183 binds 7alpha,25-dihydroxycholesterol (Sus scrofa)
RHEA:55510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:32568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (1R,4S)-camphene + diphosphate
REACT:R-DME-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Drosophila melanogaster)
RHEA:22452	skos:altLabel	"metaphosphatase"
RHEA:22452	skos:prefLabel	"endopolyphosphatase"
RHEA:22452	skos:altLabel	"polyphosphatase"
RHEA:22452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate
RHEA:22452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endopolyphosphatase"
RHEA:22452	skos:altLabel	"polyphosphate depolymerase"
REACT:R-BTA-2314678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS1 (Bos taurus)
RHEA:65674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine
GO:0019948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO activating enzyme activity
GO:0019948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMT3 activating enzyme
GO:0019948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO E1 activator enzyme
REACT:R-CFA-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)
RHEA:10098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine => a fatty acyl-[ACP] + S-adenosyl-L-methionine
EC:1.11.1.20	skos:altLabel	"prostamide F synthase"
EC:1.11.1.20	skos:altLabel	"prostamide/prostaglandin F synthase"
EC:1.11.1.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prostamide/prostaglandin F2alpha synthase"
EC:1.11.1.20	skos:altLabel	"TPGF synthase"
EC:1.11.1.20	skos:prefLabel	"prostamide/prostaglandin F2alpha synthase"
EC:1.11.1.20	skos:altLabel	"prostamide/PGF synthase"
RHEA:47601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM4 (d18:1(4E)) + H(+)
REACT:R-DRE-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Danio rerio)
REACT:R-DME-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Drosophila melanogaster)
RHEA:34890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenate(in) <=> selenate(out)
REACT:R-BTA-1236941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of receptor bound antigen into clathrin coted vesicles (Bos taurus)
REACT:R-RNO-5666197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds LIN7B (Rattus norvegicus)
REACT:R-HSA-9748996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers cleave AZA to 6MP (Homo sapiens)
REACT:R-SPO-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Schizosaccharomyces pombe)
RHEA:66913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenanthramide C + S-adenosyl-L-methionine => avenanthramide B + H(+) + S-adenosyl-L-homocysteine
RHEA:19927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + H(+) + NADH => D-ribitol 5-phosphate + NAD(+)
REACT:R-BTA-2327909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN binds collagen I, II, III, VI fibrils (Bos taurus)
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1905059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:0050415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-formiminoglutamate hydrolase activity
GO:0050415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formimidoylglutamase activity
GO:0050415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate
GO:0050415	skos:prefLabel	"formimidoylglutamase"
GO:0050415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-formimidoyl-L-glutamate formimidoylhydrolase activity
GO:0050415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formiminoglutamase activity
GO:0050415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-formimino-L-glutamate formiminohydrolase activity
GO:0050415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formiminoglutamate hydrolase activity
GO:0050415	skos:altLabel	"formiminoglutamase"
GO:0050415	skos:altLabel	"Formiminoglutamate hydrolase"
GO:0050415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formimidoylglutamase"
RHEA:41575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoxin A4 + NAD(+) <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH
REACT:R-CFA-8936519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO2:FAD dimer reduces quinones to hydroquinones (Canis familiaris)
REACT:R-CFA-391943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLT2 binds LTC4,LTD4,LTE4 (Canis familiaris)
RHEA:64342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate => (2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one
REACT:R-XTR-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Xenopus tropicalis)
GO:0030884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exogenous lipid antigen binding
REACT:R-CFA-4086132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin phosphoprotein binds integrin alphaVbeta1 (Canis familiaris)
GO:0031884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 member 1 taste receptor binding
GO:0031884	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 member 1 taste receptor ligand
RHEA:36576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sphinganine => CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine
RHEA:28380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine => ATP + N(6)-(D-fructosyl)-L-lysine
REACT:R-HSA-168326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of an Active Transcription Complex (Homo sapiens)
RHEA:58212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-447252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB1:TYK2 binds IL12RB2:JAK2 (Gallus gallus)
RHEA:56978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin] => 4-methylphenol + H2O + 2 oxidized [azurin]
GO:0140132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulfur cluster carrier activity
RHEA:30469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-endo-beta-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate
RHEA:61331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + parthenolide + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + H(+) + NADPH
REACT:R-MTU-964884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of EPSP yields chorismate (Mycobacterium tuberculosis)
REACT:R-SSC-8950485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Sus scrofa)
RHEA:65643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine
REACT:R-CFA-2168889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin-related Protein binds Hemoglobin (Canis familiaris)
RHEA:27969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate + H2O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate
RHEA:61440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + S-(2-succino)-L-cysteine = CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine
RHEA:32743	skos:altLabel	"O-acetylserine dependent cystathionine beta-synthase"
RHEA:32743	skos:prefLabel	"cystathionine beta-synthase (O-acetyl-L-serine)"
RHEA:32743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cystathionine beta-synthase (O-acetyl-L-serine)"
RHEA:32743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + O-acetyl-L-serine = acetate + H(+) + L,L-cystathionine
RHEA:19480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)
RHEA:42102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate => ATP + carbamoyl phosphate + H2O + kanamycin A
RHEA:52764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O = (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate
REACT:R-DRE-8863858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC22B, CALR, STX4, TAP and TAPBP bind (Danio rerio)
REACT:R-CEL-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
RHEA:49678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(47)-[F-actin] + NADPH + O2
REACT:R-RNO-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Rattus norvegicus)
REACT:R-XTR-8848124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAT3 (Xenopus tropicalis)
REACT:R-GGA-374723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nociceptin receptor binds to nociceptin (Gallus gallus)
RHEA:29644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaose + H2O => alpha-D-glucose + D-maltohexaose
REACT:R-SSC-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Sus scrofa)
RHEA:30156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + 2 Fe(3+) => FAD + 2 Fe(2+) + 3 H(+)
REACT:R-CFA-1295634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is serine phosphorylated in response to MAPK activation (Canis familiaris)
REACT:R-DRE-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)
RHEA:57722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + 5 H(+)(out) + phosphate => ATP + 4 H(+)(in) + H2O
RHEA:17797	skos:altLabel	"GDP-glucose-cellulose glucosyltransferase"
RHEA:17797	skos:altLabel	"GDP-glucose-beta-D-glucan glucosyltransferase"
RHEA:17797	skos:prefLabel	"cellulose synthase (GDP-forming)"
RHEA:17797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)
RHEA:17797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellulose synthase (GDP-forming)"
REACT:R-DDI-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)
RHEA:27422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (3E,6E)-alpha-farnesene + diphosphate
REACT:R-MMU-9006870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT phosphorylation (Mus musculus)
REACT:R-DDI-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Dictyostelium discoideum)
REACT:R-CFA-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Canis familiaris)
REACT:R-HSA-5635865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 dissociates from ub-PTCH1 (Homo sapiens)
REACT:R-DME-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)
RHEA:53210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => daidzein + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:11957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-glucoside + H2O => cholesterol + D-glucose
RHEA:22177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	verbascose synthase activity
REACT:R-RNO-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Rattus norvegicus)
REACT:R-SSC-5357928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLIP3 and CYLD bind TNF signaling complex (Sus scrofa)
RHEA:24002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein] => a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein]
REACT:R-DRE-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Danio rerio)
REACT:R-RNO-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)
REACT:R-BTA-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Bos taurus)
RHEA:65254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + verruculide C => (2E,6E)-farnesyl diphosphate + 6-hydroxymellein
GO:0018661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orcinol 2-monooxygenase activity
GO:0018661	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)
GO:0018661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orcinol hydroxylase activity
REACT:R-BTA-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Bos taurus)
REACT:R-RNO-140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Rattus norvegicus)
REACT:R-DRE-2064421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds ZO-2 (TJP2) (Danio rerio)
RHEA:43094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2479) in 23S rRNA
RHEA:40428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-MMU-4719413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO2 (Mus musculus)
REACT:R-CFA-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Canis familiaris)
REACT:R-GGA-9668904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18 complex (Gallus gallus)
RHEA:52937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O => (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]
REACT:R-CFA-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Canis familiaris)
REACT:R-HSA-9714481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the ER membrane (Homo sapiens)
REACT:R-RNO-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Rattus norvegicus)
REACT:R-CFA-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)
REACT:R-MMU-8948231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)
RHEA:63725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	candesartan + UDP-alpha-D-glucuronate => candesartan O-beta-D-glucuronoside + UDP
REACT:R-GGA-2132065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1r activates C1s component within C1 complement complex (Gallus gallus)
REACT:R-HSA-4332358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CaM and CAMK2 autophosphorylation (Homo sapiens)
RHEA:45149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)acryloyl-CoA + H2O => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA
REACT:R-HSA-9687458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSV1 RIR1 binds CASP8 (Homo sapiens)
REACT:R-CFA-448660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL31:IL31RA:JAK1 binds OSMR:JAK1 (Canis familiaris)
RHEA:47651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 5-phosphate + H2O <=> phosphate + ribitol
REACT:R-XTR-2684507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2, 4, (3) bind FGF2 (Xenopus tropicalis)
RHEA:65489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP => 2',3',3'-c-tri-AMP + 3 diphosphate
REACT:R-CFA-9634846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNTL (BMAL1) (Canis familiaris)
REACT:R-SSC-8865182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7A hydrolyses K11diUb (Sus scrofa)
REACT:R-CFA-210294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-2 (Canis familiaris)
RHEA:36384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl adenylate + tobramycin => AMP + H(+) + nebramycin 5'
RHEA:72319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n chloride(in) + urate(out) = n chloride(out) + urate(in)
REACT:R-DDI-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)
GO:0080089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity
RHEA:55529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-tyrosine + O2 => (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)
RHEA:25313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O2 => glycolate + O2
REACT:R-CFA-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Canis familiaris)
REACT:R-CFA-9758674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)
REACT:R-SSC-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Sus scrofa)
RHEA:17722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-3222020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUAK1 phosphorylates TP53 (Homo sapiens)
RHEA:16724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-XTR-9679740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA4:ITGB1 binds natalizumab (Xenopus tropicalis)
REACT:R-CFA-6810357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fillagrin and keratin intermediate filaments polymerise forming a network (Canis familiaris)
RHEA:43276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GalNAc-GD1a + H(+) + UDP
REACT:R-GGA-5683735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 is recruited to DNA DSBs (Gallus gallus)
REACT:R-SSC-936952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Sus scrofa)
REACT:R-DRE-8851888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds SHC1-2 (Danio rerio)
RHEA:53567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)
RHEA:38614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) <=> cyclic ADP-beta-D-ribose + H(+) + nicotinamide
REACT:R-GGA-9653503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B is phosphorylated on serine 181 (Gallus gallus)
REACT:R-BTA-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Bos taurus)
REACT:R-CFA-8857555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates GPNMB (Canis familiaris)
RHEA:42168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH
RHEA:49176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine
RHEA:32492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) => all-trans-4,4'-diapolycopene + 4 FADH2
REACT:R-BTA-390597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Bos taurus)
REACT:R-HSA-8854182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D17 binds OPTN:RAB8A (Homo sapiens)
REACT:R-SSC-9618378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 binds the Nup107-Nup160 complex (Sus scrofa)
REACT:R-HSA-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
RHEA:37700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
RHEA:49885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Saccharomyces cerevisiae)
RHEA:57880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP
REACT:R-CFA-5690988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-incision of DNA by ERCC5 (XPG) in GG-NER (Canis familiaris)
REACT:R-HSA-2454239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SYK (Homo sapiens)
REACT:R-CFA-2428926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Canis familiaris)
REACT:R-GGA-375790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Gallus gallus)
RHEA:27833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neryl diphosphate <=> beta-phellandrene + diphosphate
REACT:R-SSC-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)
REACT:R-SCE-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Saccharomyces cerevisiae)
REACT:R-GGA-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Gallus gallus)
REACT:R-BTA-9708866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-F2R binds vorapaxar (Bos taurus)
GO:0102498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose glucosidase activity
EC:1.21.98.-	skos:prefLabel	"With other, known acceptors"
EC:1.21.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known acceptors"
REACT:R-HSA-2029458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)
RHEA:65154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-naringenin + UDP-alpha-D-glucose
RHEA:28558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + H2O = D-fructose + phosphate
RHEA:70126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-140978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex binds FADD (Rattus norvegicus)
RHEA:65708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GDP-beta-L-galactose = beta-L-galactose 1-phosphate + GDP-alpha-D-mannose
REACT:R-CFA-9658445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Canis familiaris)
REACT:R-MMU-1855172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Mus musculus)
REACT:R-DRE-163320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of mTERF with the termination sequence (Danio rerio)
REACT:R-CFA-176664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + PAPS => estrone 3-sulfate + PAP (Canis familiaris)
RHEA:57871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 <=> (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate
REACT:R-GGA-1592436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP9 by MMPs (Gallus gallus)
REACT:R-DRE-112271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex dissociates (Danio rerio)
REACT:R-HSA-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
RHEA:35685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecasphinganine + H(+) + NADPH => hexadecasphinganine + NADP(+)
REACT:R-HSA-4086223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IX binds integrin alpha11beta1 (Homo sapiens)
RHEA:60689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) => (11R)-dihydroartemisinate + 2 H(+) + NADH
RHEA:11679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose + H2O + NADP(+) <=> D-ribonate + 2 H(+) + NADPH
REACT:R-BTA-6805740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 methylates TP53 (Bos taurus)
REACT:R-SSC-9690449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 bind S1P (Sus scrofa)
GO:0102808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity
RHEA:43343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]
REACT:R-DRE-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Danio rerio)
REACT:R-CFA-9027627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Canis familiaris)
RHEA:69479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysine <=> CoA + H(+) + N(6)-acetyl-L-lysine
REACT:R-CEL-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Caenorhabditis elegans)
RHEA:43995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 <=> 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)
RHEA:33030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one
RHEA:24027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
REACT:R-HSA-420019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Claudins create paired strands through homophilic and heterophilic cis and trans interactions (Homo sapiens)
REACT:R-XTR-9035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysS248-MPST:TXN2 dissociates (Xenopus tropicalis)
REACT:R-GGA-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Gallus gallus)
REACT:R-DRE-9026911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Danio rerio)
REACT:R-HSA-2219536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant binds PIP2 (Homo sapiens)
REACT:R-HSA-349455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MDM4 by ATM (Homo sapiens)
REACT:R-HSA-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Homo sapiens)
RHEA:18624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2S)-flavan-4-one + O2 <=> a (2R,3R)-dihydroflavonol + CO2 + succinate
RHEA:34822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocurcumin + NADP(+) <=> curcumin + H(+) + NADPH
RHEA:51342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2
GO:0102306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-benzoin + NADP(+) = benzil + H(+) + NADPH
GO:0102306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzil reductase [(S)-benzoin-forming] activity
REACT:R-HSA-8932599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALB1 binds 4xCa2+ (Homo sapiens)
REACT:R-GGA-177925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds to the phosphorylated EGF receptor:ligand complex (Gallus gallus)
REACT:R-CFA-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Canis familiaris)
REACT:R-GGA-4085372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO2,3 (Gallus gallus)
GO:0015208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine transmembrane transporter activity
GO:0033714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyvinyl alcohol oxidase activity
GO:0033714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	secondary-alcohol:oxygen oxidoreductase activity
GO:0033714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	secondary alcohol oxidase activity
GO:0033714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secondary-alcohol oxidase activity
RHEA:60370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urate(in) => urate(out)
RHEA:22260	skos:prefLabel	"triacetate-lactonase"
RHEA:22260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triacetate lactone = H(+) + triacetate
RHEA:22260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"triacetate-lactonase"
REACT:R-MMU-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Mus musculus)
RHEA:57580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thiol-D-ribulose 5-phosphate
GO:0030597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA glycosylase activity
RHEA:50528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]
REACT:R-BTA-5654655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PPTN11 (Bos taurus)
REACT:R-MMU-9706298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CSK (Mus musculus)
REACT:R-GGA-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Gallus gallus)
REACT:R-HSA-5687090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)
GO:0102970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetic acid glucosyltransferase activity
GO:0102970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetate + UDP-alpha-D-glucose = 7-deoxyloganate + H(+) + UDP
GO:0102970	skos:prefLabel	"7-deoxyloganetic acid glucosyltransferase"
GO:0102970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-deoxyloganetic acid glucosyltransferase"
REACT:R-SSC-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Sus scrofa)
REACT:R-XTR-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Xenopus tropicalis)
GO:0046537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGAM-i
GO:0046537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GO:0022874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellobiose PTS transporter activity
GO:0022874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity
REACT:R-GGA-9007882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 is cleaved (Gallus gallus)
RHEA:18827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->6)-alpha-D-glucosyl](n+1) + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose
REACT:R-SSC-8848713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds BCAR1 (Sus scrofa)
REACT:R-HSA-76456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-atom dealkylation of dextromethorphan (Homo sapiens)
REACT:R-XTR-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Xenopus tropicalis)
RHEA:52961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyocholate + UDP-alpha-D-glucuronate => hyocholoyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-BTA-508282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK is a substrate for JAK1 (Bos taurus)
GO:0052723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol hexakisphosphate 1-kinase activity
REACT:R-SCE-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Saccharomyces cerevisiae)
GO:0034532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity
REACT:R-CFA-76354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vinyl chloride is oxidized to 2-Chloroethylene oxide (Canis familiaris)
RHEA:51863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + umbelliferone <=> 8-geranylumbelliferone + diphosphate
EC:2.8.3.21	skos:prefLabel	"L-carnitine CoA-transferase"
EC:2.8.3.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-carnitine CoA-transferase"
RHEA:33029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene
RHEA:71824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodo-L-thyronine(out) => 3,3'-diiodo-L-thyronine(in)
REACT:R-HSA-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)
REACT:R-GGA-8874083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y397-PTK2 binds SRC (Gallus gallus)
RHEA:27914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate
RHEA:29920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)
RHEA:44936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate
RHEA:56843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-2-hydroxybenzoate + O2 <=> (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)
RHEA:40830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
RHEA:34110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H(+) + hexadecanoyl-CoA <=> 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA
RHEA:60607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline
REACT:R-GGA-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Gallus gallus)
RHEA:60800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A53 + O2 = CO2 + gibberellin A44 + succinate
RHEA:11799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone + O2 <=> 3-dehydroecdysone + H2O2
REACT:R-HSA-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Homo sapiens)
REACT:R-MMU-1297354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acrosin Cleavage (Mus musculus)
REACT:R-CFA-2022368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-42) (Canis familiaris)
RHEA:19912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate
GO:0033895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease (uracil-specific) activity
GO:0033895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uracil-specific endoribonuclease activity
GO:0033895	skos:prefLabel	"ribonuclease [poly-(U)-specific]"
GO:0033895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease [poly-(U)-specific]"
GO:0033895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease [poly-(U)-specific] activity
GO:0033895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uracil-specific RNase activity
RHEA:55611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base
RHEA:59711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotriono-1,5-lactone + H2O <=> D-maltotrionate + H(+)
REACT:R-MMU-2046089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Mus musculus)
REACT:R-MMU-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Mus musculus)
RHEA:18328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-amorpha-4,11-diene + diphosphate
REACT:R-SSC-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Sus scrofa)
RHEA:69034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-nitrosobutanedioate + H2O => N,N-dihydroxy-L-aspartate
REACT:R-CFA-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Canis familiaris)
REACT:R-MMU-9647645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD oligomerizes into arc-, slit-shaped structures (Mus musculus)
RHEA:63953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid 1-phosphate + H2O => a sphingoid base + phosphate
RHEA:40121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + tetradecanoate => H2O + tetradecanoyl-CoA
REACT:R-GGA-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Gallus gallus)
RHEA:14559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + vomilenine => H2O + raucaffricine
REACT:R-SPO-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Schizosaccharomyces pombe)
REACT:R-XTR-2997709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO1 (Xenopus tropicalis)
RHEA:72725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-xylose(out) + UMP(in) => UDP-alpha-D-xylose(in) + UMP(out)
REACT:R-CFA-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Canis familiaris)
RHEA:28471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine(in) => pyridoxine(out)
REACT:R-SCE-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Saccharomyces cerevisiae)
REACT:R-HSA-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
RHEA:61773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside E + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP
REACT:R-DRE-210285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homophilic interaction of PECAM-1 (Danio rerio)
REACT:R-HSA-211247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DNA by DFF40 (Homo sapiens)
REACT:R-XTR-9036727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAA hydrolyzes lysosomal glycogen (Xenopus tropicalis)
REACT:R-SCE-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Saccharomyces cerevisiae)
RHEA:65847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + phosphate(in) <=> ADP(in) + phosphate(out)
REACT:R-XTR-266299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds membrane-associated free cholesterol and phospholipids (Xenopus tropicalis)
RHEA:18005	skos:prefLabel	"erythrulose reductase"
RHEA:18005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"erythrulose reductase"
RHEA:18005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH
RHEA:18005	skos:altLabel	"D-erythrulose reductase"
RHEA:46512	skos:prefLabel	"dihydroceramide fatty acyl 2-hydroxylase"
RHEA:46512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroceramide fatty acyl 2-hydroxylase"
RHEA:46512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:46512	skos:altLabel	"plant sphingolipid fatty acid 2-hydroxylase"
REACT:R-XTR-421836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Vesicle Uncoating (Xenopus tropicalis)
REACT:R-HSA-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Homo sapiens)
REACT:R-BTA-1602454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proMMP9 binds TIMP1 (Bos taurus)
REACT:R-MMU-9699579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of FLT3  (Mus musculus)
REACT:R-RNO-5635845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind CDC73 (Rattus norvegicus)
REACT:R-DRE-5676597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Danio rerio)
REACT:R-MMU-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Mus musculus)
REACT:R-RNO-5682992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A,B bind H4K20Me2 (Rattus norvegicus)
RHEA:10537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate
REACT:R-SSC-9006850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor JAK phosphorylation (Sus scrofa)
REACT:R-DDI-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Dictyostelium discoideum)
REACT:R-MMU-6807008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates MET (Mus musculus)
RHEA:65450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + ethyl butanoate => butanoyl-CoA + ethanol
REACT:R-XTR-5694563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD10 hydrolyses MPAG (Xenopus tropicalis)
REACT:R-XTR-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Xenopus tropicalis)
RHEA:42996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = (R)-cembrene A + diphosphate
RHEA:42996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cembrene A synthase"
RHEA:42996	skos:prefLabel	"cembrene A synthase"
GO:0010294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisic acid glucosyltransferase activity
RHEA:13720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 4-phosphate + NADP(+) <=> 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH
REACT:R-PFA-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Plasmodium falciparum)
REACT:R-SSC-8875902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC45A3 transports Glc from extracellular region to cytosol (Sus scrofa)
RHEA:15305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH
RHEA:15305	skos:altLabel	"betaine aldehyde dehydrogenase"
RHEA:15305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"betaine-aldehyde dehydrogenase"
RHEA:15305	skos:altLabel	"BADH"
RHEA:15305	skos:prefLabel	"betaine-aldehyde dehydrogenase"
RHEA:15305	skos:altLabel	"betaine aldehyde oxidase"
REACT:R-HSA-174731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of newly synthesized ApoB-48 (Homo sapiens)
REACT:R-RNO-4568914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of BLM with SUMO2,3 (Rattus norvegicus)
GO:0046988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asioloorosomucoid beta-1,3-glucuronosyltransferase activity
RHEA:53778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfinopropanoate + H(+) => 3-sulfanylpropanoate + O2
RHEA:46841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:37594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
RHEA:56725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-beta-carotene + O2 => 4-hydroxy-all-trans-beta-carotene + A + H2O
REACT:R-GGA-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Gallus gallus)
REACT:R-CEL-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Caenorhabditis elegans)
REACT:R-HSA-164513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' PPT-primed initiation of plus-strand DNA synthesis  (Homo sapiens)
REACT:R-SSC-9009488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 binds CSF1 (Sus scrofa)
RHEA:33775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)
REACT:R-BTA-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Bos taurus)
REACT:R-MMU-6793685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated TP53 translocates to the cytosol (Mus musculus)
REACT:R-XTR-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)
RHEA:56282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + L-prolyl-[peptidyl-carrier protein] => 3'-L-prolyl-AMP + holo-[peptidyl-carrier protein]
REACT:R-CFA-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Canis familiaris)
RHEA:42603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + prostaglandin G2 <=> A + H2O + prostaglandin H2
REACT:R-SCE-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Saccharomyces cerevisiae)
REACT:R-XTR-418845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of caspase-3 (Xenopus tropicalis)
REACT:R-CFA-964773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXGR1 binds 2OG (Canis familiaris)
RHEA:69233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hydroxypropyl glucosinolate + H2O => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
REACT:R-CFA-3785684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by CTSG (Canis familiaris)
RHEA:53734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate
REACT:R-HSA-266051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
RHEA:10324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-glycol + NADP(+) = a 2-hydroxycarbonyl + H(+) + NADPH
RHEA:25122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate => H(+) + H2O + L-1-piperideine-6-carboxylate
GO:0043431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octaprenyl-6-hydroxy phenol methylase activity
GO:0043431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinone-9 3-methyltransferase activity
GO:0043431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity
RHEA:61997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + lactoyl-CoA => CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]
REACT:R-HSA-5649734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)
REACT:R-GGA-390886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH4 binds Hist (Gallus gallus)
RHEA:53293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin => H(+) + N-carbamoyl-L-methionine
REACT:R-BTA-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Bos taurus)
RHEA:28972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + shikimate(in) => H(+)(out) + shikimate(out)
RHEA:44626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+)
RHEA:59497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0080101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
REACT:R-HSA-9626242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-GFAP:GFAP dissociates from LAMP2a multimer (Homo sapiens)
REACT:R-CFA-8954262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Canis familiaris)
REACT:R-CFA-200424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Canis familiaris)
REACT:R-MMU-177935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)
REACT:R-CFA-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)
RHEA:35948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochanoclavine-I aldehyde + NADP(+) => chanoclavine-I aldehyde + H(+) + NADPH
REACT:R-SSC-8871266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD3 (Sus scrofa)
RHEA:60706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-SPO-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Schizosaccharomyces pombe)
RHEA:51258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2
RHEA:23557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + L-glutamine => gamma-L-glutamyl-D-alanine + NH4(+)
REACT:R-SSC-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Sus scrofa)
RHEA:64512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine
REACT:R-HSA-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Homo sapiens)
RHEA:22243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylenediurea <=> N-(carboxyaminomethyl)urea + NH4(+)
REACT:R-HSA-5210923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cya and lef bind to pagA(197-794):ANTXR1 oligomer (Homo sapiens)
RHEA:53120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH
EC:4.2.1.17	skos:prefLabel	"enoyl-CoA hydratase"
EC:4.2.1.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enoyl-CoA hydratase"
EC:4.2.1.17	skos:altLabel	"unsaturated acyl-CoA hydratase"
EC:4.2.1.17	skos:altLabel	"enoyl hydrase"
REACT:R-XTR-9718020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PTGFR agonists (Xenopus tropicalis)
REACT:R-XTR-202233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Lck by Csk (Xenopus tropicalis)
REACT:R-CFA-2731122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2 & 4 bind VTN (Canis familiaris)
REACT:R-XTR-1008200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 binds the beta globin locus control region (Xenopus tropicalis)
REACT:R-GGA-353484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uracil glycosylase mediated recognition and binding of uracil opposite guanine (Gallus gallus)
REACT:R-SCE-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Saccharomyces cerevisiae)
REACT:R-DME-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Drosophila melanogaster)
RHEA:11796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ecdysone oxidase"
RHEA:11796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone + O2 = 3-dehydroecdysone + H2O2
RHEA:11796	skos:prefLabel	"ecdysone oxidase"
RHEA:23336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O2 + 2 iodide = diiodine + 2 H2O
REACT:R-BTA-8858428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FCAMR binds IgA (Bos taurus)
REACT:R-GGA-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)
RHEA:52428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-leukotriene B4 + H(+) + NADH = 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)
REACT:R-DME-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Drosophila melanogaster)
REACT:R-HSA-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Homo sapiens)
RHEA:34702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-alpha-isocomene + diphosphate
REACT:R-XTR-5685649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPAs translocate from ER membrane to extracellular region (Xenopus tropicalis)
REACT:R-HSA-8978926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYBL2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)
RHEA:42985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate => diphosphate + pimara-8(14),15-diene
REACT:R-CFA-1254386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 forms a complex with estrogen receptor ESR1 (Canis familiaris)
REACT:R-XTR-5694109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer hydrolyses TAG to DAG and FA (Xenopus tropicalis)
RHEA:59848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)
REACT:R-CEL-428205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [Golgi] (Caenorhabditis elegans)
RHEA:54806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4'-disulfanyldibutanoate + H(+) + NADH => 2 4-sulfanylbutanoate + NAD(+)
RHEA:50419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] <=> H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)
REACT:R-BTA-879584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO3A1 isoform 1 has abroad substrate specificity (Bos taurus)
RHEA:42557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2819) in 21S rRNA => pseudouridine(2819) in 21S rRNA
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrogen oxide reductase activity
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrous-oxide:(acceptor) oxidoreductase (NO-forming)
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CYP55
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + nitrous oxide = 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitric-oxide reductase (cytochrome c)"
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrous-oxide:acceptor oxidoreductase (NO-forming)
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitric-oxide reductase activity
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome bc nitric oxide reductase activity
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide reductase activity
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P450 nitric oxide reductase activity
GO:0016966	skos:prefLabel	"nitric-oxide reductase (cytochrome c)"
GO:0016966	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P450nor
RHEA:12773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + proclavaminate = CO2 + dihydroclavaminate + H2O + succinate
RHEA:38131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
RHEA:47055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> alpha-selinene + diphosphate
RHEA:27991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose + ATP => 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)
RHEA:46946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH => (S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+)
REACT:R-XTR-1638845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERK phosphorylates CERA to form C1P (Xenopus tropicalis)
REACT:R-GGA-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Gallus gallus)
RHEA:19173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"naphthalene 1,2-dioxygenase"
RHEA:19173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + naphthalene + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)
RHEA:19173	skos:prefLabel	"naphthalene 1,2-dioxygenase"
REACT:R-CFA-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Canis familiaris)
RHEA:50959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine
RHEA:37865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA
RHEA:70546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-BTA-9714363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC translocates to the endoplasmic reticulum membrane (Bos taurus)
REACT:R-HSA-176879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein(a) + LDL => Lp(a) (Homo sapiens)
REACT:R-HSA-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Homo sapiens)
RHEA:47194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]
REACT:R-DME-1234173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
RHEA:46379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:59452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + NADP(+) = a long-chain fatty aldehyde + H(+) + NADPH
REACT:R-DRE-5666160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates DIAPH2-2 at kinetochores (Danio rerio)
REACT:R-DME-5607728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Drosophila melanogaster)
REACT:R-DME-204871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb2 (Drosophila melanogaster)
REACT:R-RNO-936564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 inhibits MAVS-DDX58 interaction. (Rattus norvegicus)
RHEA:59063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + H2O <=> (20S)-ginsenoside Rh2 + D-glucose
RHEA:36355	skos:altLabel	"tRNA-yW synthesizing enzyme-2"
RHEA:36355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase"
RHEA:36355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine
RHEA:36355	skos:prefLabel	"tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase"
REACT:R-SSC-400509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Sus scrofa)
REACT:R-CEL-6809309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR6 binds MTMR9 (Caenorhabditis elegans)
RHEA:58033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+) => dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2
REACT:R-CEL-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Caenorhabditis elegans)
REACT:R-MMU-3465545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Mus musculus)
REACT:R-GGA-420274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIP receptor binds gastric inhibitory peptide (Gallus gallus)
RHEA:30711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linalool dehydratase"
RHEA:30711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-linalool = beta-myrcene + H2O
RHEA:30711	skos:prefLabel	"linalool dehydratase"
REACT:R-XTR-77585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Xenopus tropicalis)
RHEA:32755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + 2-oxoglutarate + O2 = apigenin + CO2 + H(+) + H2O + succinate
REACT:R-HSA-114542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1,RAC2,RHOG activate PI3K (Homo sapiens)
REACT:R-HSA-8987220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Homo sapiens)
REACT:R-CFA-73739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Canis familiaris)
RHEA:61957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:13751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-triphosphate + AMP
GO:0070226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide:ferric ion oxidoreductase
GO:0070226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur:ferric ion oxidoreductase activity
REACT:R-GGA-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Gallus gallus)
RHEA:10930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:38114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NADP(+) <=> H(+) + L-glyceraldehyde + NADPH
REACT:R-CEL-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Caenorhabditis elegans)
REACT:R-SPO-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)
REACT:R-CFA-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Canis familiaris)
RHEA:68529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => beta-bisabolene + diphosphate
RHEA:68323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,4,5-triphosphate + H2O <=> 1D-myo-inositol 2,5-bisphosphate + phosphate
GO:0042329	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	structural constituent of cuticle
GO:0042329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of collagen and cuticulin-based cuticle
RHEA:72157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out) => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in)
RHEA:56923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + ATP + H(+) <=> a medium-chain fatty acyl-AMP + diphosphate
RHEA:41190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate
REACT:R-CFA-2990880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6/NEK7 phosphorylates NUP98 (Canis familiaris)
REACT:R-MMU-4085994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates SIN3A with SUMO1 (Mus musculus)
REACT:R-MMU-5686072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-3Y-SHC1 dissociates from IGF1R (Mus musculus)
RHEA:28775	skos:prefLabel	"dinoflagellate luciferase"
RHEA:28775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dinoflagellate luciferase"
RHEA:28775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dinoflagellate luciferin + O2 = H(+) + H2O + hnu + oxidized dinoflagellate luciferin
REACT:R-BTA-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Bos taurus)
REACT:R-GGA-2179413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC-alpha  activate MMP3 (Gallus gallus)
REACT:R-BTA-8956659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates YAP1 (Bos taurus)
REACT:R-DRE-9761344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 binds IKBKG within IKK complex (Danio rerio)
RHEA:33858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + GDP + H(+)
REACT:R-GGA-73729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of SL1 (Gallus gallus)
REACT:R-HSA-388833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CTLA-4 (Homo sapiens)
REACT:R-HSA-449811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)
REACT:R-HSA-1791173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ATF3 (Homo sapiens)
GO:0043866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)
GO:0043866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin-dependent 5'-adenylylsulfate reductase activity
GO:0043866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)
GO:0043866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-sulfate reductase (thioredoxin) activity
RHEA:54805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 4-sulfanylbutanoate + NAD(+) => 4,4'-disulfanyldibutanoate + H(+) + NADH
REACT:R-SSC-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)
RHEA:70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acyl-3-oxosphinganine => 3-oxosphinganine + a fatty acyl-CoA
RHEA:66905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cannabinerolate => AH2 + cannabichromenate
GO:0071208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone pre-mRNA DCP binding
RHEA:65988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	previtamin D3 = calciol
RHEA:38307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA
RHEA:46032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + tetradecanoate = (2S)-hydroxytetradecanoate + H2O
RHEA:52757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate
REACT:R-HSA-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Homo sapiens)
EC:1.14.19.69	skos:prefLabel	"biflaviolin synthase"
EC:1.14.19.69	skos:altLabel	"CYP158A2"
EC:1.14.19.69	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biflaviolin synthase"
REACT:R-HSA-380076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 1 (NK1) binds to substance P (Homo sapiens)
RHEA:20086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucoside + malonyl-CoA => a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA
REACT:R-DME-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Drosophila melanogaster)
RHEA:33797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + beta-D-fructose => H2O + sucrose
REACT:R-DDI-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Dictyostelium discoideum)
REACT:R-XTR-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Xenopus tropicalis)
RHEA:31649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O
REACT:R-CEL-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Caenorhabditis elegans)
RHEA:56855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reumycin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toxoflavin
REACT:R-RNO-5685607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sialic acid binds SIGLEC (Rattus norvegicus)
REACT:R-MMU-9018594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds LBR (Mus musculus)
GO:0106292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	superoxide-generating NADPH oxidase activity
GO:0106292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide
REACT:R-MMU-2179274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)
REACT:R-CFA-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)
REACT:R-MMU-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Mus musculus)
RHEA:57832	skos:prefLabel	"glutarate-semialdehyde dehydrogenase"
RHEA:57832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutarate-semialdehyde dehydrogenase"
RHEA:57832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxopentanoate + H2O + NADP(+) = glutarate + 2 H(+) + NADPH
EC:3.4.24.73	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"jararhagin"
EC:3.4.24.73	skos:altLabel	"HF2-proteinase"
EC:3.4.24.73	skos:prefLabel	"jararhagin"
EC:1.1.99.36	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol dehydrogenase (nicotinoprotein)"
EC:1.1.99.36	skos:altLabel	"nicotinoprotein alcohol dehydrogenase"
EC:1.1.99.36	skos:altLabel	"NDMA-dependent alcohol dehydrogenase"
EC:1.1.99.36	skos:prefLabel	"alcohol dehydrogenase (nicotinoprotein)"
REACT:R-DME-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Drosophila melanogaster)
RHEA:13278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate
RHEA:69192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-glutamyl-[tubulin] = ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate
RHEA:67759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
GO:0052797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-methyl-glucuronoyl methylesterase activity
GO:0052797	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glucuronoyl esterase activity
REACT:R-DDI-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:51509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-proline + O2 => CO2 + succinate + trans-4-hydroxy-L-proline
RHEA:68574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine(out) => L-tyrosine(in)
RHEA:54619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + heptadecanoyl-CoA + O2 <=> 2-hydroxyheptadecanoyl-CoA + CO2 + succinate
REACT:R-SSC-5653878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Sus scrofa)
REACT:R-DME-71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)
RHEA:67437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:41353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine
REACT:R-DDI-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Dictyostelium discoideum)
GO:0051268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-keto amide reductase activity
REACT:R-XTR-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Xenopus tropicalis)
REACT:R-RNO-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Rattus norvegicus)
RHEA:61198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]
RHEA:12311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H2O + NAD(+) <=> 2 H(+) + L-2-aminoadipate + NADH
REACT:R-DME-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Drosophila melanogaster)
REACT:R-SSC-166795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Classical C3 convertase (C4b:C2a complex) (Sus scrofa)
REACT:R-DRE-5689085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds polyUb-PARK2 (Danio rerio)
REACT:R-RNO-176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST trimers transfer GS from GSH to luminal substrates (Rattus norvegicus)
RHEA:68708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = diphosphate + linalool
RHEA:55569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine => 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine
RHEA:12936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuculose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate
REACT:R-GGA-450325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-FOS activation by phospho ERK1/2 (Gallus gallus)
REACT:R-BTA-975147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)
RHEA:25242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + H2O => (S)-ureidoglycolate + NH4(+)
RHEA:48965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 => [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O
RHEA:71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-lysyl-glycine(out) <=> H(+)(in) + L-lysyl-glycine(in)
REACT:R-HSA-74993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Homo sapiens)
RHEA:19022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP
REACT:R-MMU-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Mus musculus)
REACT:R-BTA-109514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Bos taurus)
REACT:R-BTA-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Bos taurus)
REACT:R-HSA-2976563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter (Homo sapiens)
REACT:R-DRE-380272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plk1-mediated phosphorylation of Nlp (Danio rerio)
REACT:R-HSA-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Homo sapiens)
REACT:R-DDI-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Dictyostelium discoideum)
REACT:R-SSC-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Sus scrofa)
REACT:R-HSA-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Homo sapiens)
RHEA:16679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetate + 2 H(+) + NADH => fluoroacetaldehyde + H2O + NAD(+)
REACT:R-DRE-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Danio rerio)
RHEA:20239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+) => (1S,4S)-5-oxo-1,2-campholide
RHEA:24951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methylglutarate + malonyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + malonate
REACT:R-DRE-751001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (i) reassociates with G beta:gamma (Danio rerio)
REACT:R-HSA-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Homo sapiens)
REACT:R-CFA-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Canis familiaris)
REACT:R-HSA-9007926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATRX binds DAXX (Homo sapiens)
RHEA:30209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin] => H2O + methylamine + 2 oxidized [amicyanin]
REACT:R-XTR-77312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Xenopus tropicalis)
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endothelium-derived relaxation factor-forming enzyme activity
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NO synthase activity
GO:0004517	skos:altLabel	"endothelium-derived relaxation factor-forming enzyme"
GO:0004517	skos:altLabel	"NO synthase"
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitric-oxide synthetase activity
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endothelium-derived relaxing factor synthase activity
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-diaphorase activity
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitric-oxide synthase (NADPH)"
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide synthase activity
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitric oxide synthetase activity
GO:0004517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric-oxide synthase activity
GO:0004517	skos:altLabel	"nitric-oxide synthetase"
GO:0004517	skos:prefLabel	"nitric-oxide synthase (NADPH)"
GO:0004517	skos:altLabel	"endothelium-derived relaxing factor synthase"
GO:0004517	skos:altLabel	"NADPH-diaphorase"
RHEA:70710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-beta-D-quinovose <=> 6-sulfo-D-rhamnose
REACT:R-DRE-193995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 18-hydroxylates CORST to 18HCORST (Danio rerio)
REACT:R-XTR-420724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds Ca2+ (Xenopus tropicalis)
REACT:R-DRE-170131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Danio rerio)
REACT:R-GGA-6791109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds PCNA (Gallus gallus)
RHEA:14005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L,L-cystathionine = 2-oxobutanoate + L-cysteine + NH4(+)
REACT:R-CEL-427656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-GGA-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)
REACT:R-GGA-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Gallus gallus)
RHEA:58845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeranial + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH
RHEA:41571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin T + dTDP-2-deoxy-beta-L-fucose <=> aclacinomycin S + dTDP + H(+)
REACT:R-SPO-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Schizosaccharomyces pombe)
REACT:R-BTA-6809663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hair keratin fibres (Bos taurus)
REACT:R-BTA-5693108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Bos taurus)
REACT:R-HSA-264997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cysteine to cystine in Proinsulin (Homo sapiens)
RHEA:36985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA
RHEA:71814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) <=> 3,3',5-triiodo-L-thyronine(in)
REACT:R-SSC-8866268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADBRK1,2 phosphorylate AVPR2 (Sus scrofa)
REACT:R-HSA-141310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)
REACT:R-BTA-8865994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds PTPN11 (Bos taurus)
RHEA:23314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1(F)-beta-D-fructosylsucrose + D-glucose => 2 sucrose
GO:0004076	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin synthetase activity
GO:0004076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin synthase activity
GO:0004076	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dethiobiotin:sulfur sulfurtransferase activity
REACT:R-DME-1602417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Drosophila melanogaster)
REACT:R-XTR-9006870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT phosphorylation (Xenopus tropicalis)
RHEA:30562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O <=> guanosine + H(+) + triphosphate
REACT:R-HSA-211904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F12 18-hydroxylates ARA (Homo sapiens)
REACT:R-BTA-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Bos taurus)
REACT:R-GGA-374337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apelin receptor binds to apelin (Gallus gallus)
RHEA:27920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + propanoate => H2O + NADP(+) + propanal
RHEA:30732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + FAD + H(+) => (2E)-butenoyl-CoA + FADH2
GO:0046429	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity
GO:0046429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity
GO:0046429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase activity
GO:0046429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity
GO:0046429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity
RHEA:56793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]
RHEA:64263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + glycine <=> CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine
REACT:R-RNO-5693542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RPA complexes with ssDNA at resected DNA DSBs (Rattus norvegicus)
RHEA:61322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:68376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-asparagine = 2-oxosuccinamate + glycine
REACT:R-CFA-450173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 induces oligomerisation of TRAF6 (Canis familiaris)
REACT:R-GGA-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Gallus gallus)
RHEA:18394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine
RHEA:35930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	paromamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP
RHEA:31251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxyisobutanoyl-CoA + H2O = (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)
REACT:R-CFA-2029273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to p-6Y-SYK (Canis familiaris)
RHEA:41991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH
RHEA:69722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + ATP + H(+) <=> (indol-3-yl)acetyl-AMP + diphosphate
RHEA:22507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate
REACT:R-DRE-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Danio rerio)
RHEA:59265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-SSC-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Sus scrofa)
REACT:R-MMU-177944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)
RHEA:23077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoyl-CoA + chloride + NADP(+) => 2,4-dichlorobenzoyl-CoA + NADPH
RHEA:20051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O
RHEA:33617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + octadecanoyl-CoA => ATP + CoA + octadecanoate
RHEA:16719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + FADH2 => deoxycholate + FAD + H(+) + H2O
REACT:R-CEL-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
RHEA:10897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + limonin => 2 H(+) + limonoate
RHEA:53615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + D-ribulose 5-phosphate + H(+) <=> CDP-D-ribulose + diphosphate
RHEA:44236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-SCE-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Saccharomyces cerevisiae)
REACT:R-DME-9632034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GlcA to chondroitin (Drosophila melanogaster)
REACT:R-DDI-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Dictyostelium discoideum)
RHEA:20107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + beta-D-fructose 1,6-bisphosphate + H(+) => ADP + beta-D-fructose 6-phosphate
RHEA:28614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1Z,2S)-2-methylbutanal oxime = (2S)-2-methylbutanenitrile + H2O
RHEA:20890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O
GO:0004862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP-dependent protein kinase inhibitor activity
GO:0004862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Homo sapiens)
RHEA:18682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine => phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
RHEA:68458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-glutaconyl-CoA + H2O => (S)-3-hydroxyglutaryl-CoA
RHEA:68173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 => CO2 + H2O + isodomoate A + succinate
REACT:R-BTA-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Bos taurus)
RHEA:24290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine => 5-formimidoyltetrahydrofolate + glycine
REACT:R-DRE-2022061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan sulfate can be further sulfated on position 2 of iduronate (Danio rerio)
RHEA:54622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyeicosanoyl-CoA + CO2 + succinate => 2-oxoglutarate + eicosanoyl-CoA + O2
REACT:R-RNO-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Rattus norvegicus)
REACT:R-RNO-379395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)
REACT:R-HSA-1592241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SSBP1 (Homo sapiens)
REACT:R-RNO-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Rattus norvegicus)
REACT:R-CFA-9750942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP14 deubiquitinates NLRC5 (Canis familiaris)
REACT:R-CEL-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Caenorhabditis elegans)
REACT:R-MMU-264678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Mus musculus)
REACT:R-HSA-174451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)
REACT:R-HSA-9750946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
EC:3.4.21.49	skos:prefLabel	"hypodermin C"
EC:3.4.21.49	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hypodermin C"
EC:3.4.21.49	skos:altLabel	"Hypoderma collagenase"
REACT:R-SSC-1971482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Sus scrofa)
RHEA:64693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutanol + NAD(+) => 2-methylpropanal + H(+) + NADH
REACT:R-SSC-5621370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Sus scrofa)
REACT:R-CEL-5225602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR5 binds Me2sR3-replicative histone H3 (Caenorhabditis elegans)
GO:0034452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynactin binding
REACT:R-CFA-917891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Canis familiaris)
RHEA:54907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH <=> (9Z)-hexadecenoyl-[ACP] + NAD(+)
REACT:R-MMU-374787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR neuropeptide receptor binds neuropeptides B and W (Mus musculus)
REACT:R-HSA-6814187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVL:PPL heterodimer binds the inner surface of the plasma membrane (Homo sapiens)
REACT:R-CFA-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)
REACT:R-CEL-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Caenorhabditis elegans)
REACT:R-HSA-8934465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds PTPN12 (Homo sapiens)
REACT:R-XTR-77613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR2 homodimer to dsRNA duplex (Xenopus tropicalis)
RHEA:44453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
RHEA:49224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]
RHEA:10373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + phenylglyoxylate => benzoyl-CoA + CO2 + NADH
RHEA:61482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+) => a sphingoid base + a very long-chain fatty acyl-CoA
RHEA:57729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + trans-aconitate => CO2 + itaconate
RHEA:61500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin + UDP-alpha-D-glucose = delphinidin 3-O-beta-D-glucoside + UDP
REACT:R-HSA-6785860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SOCS1 (Homo sapiens)
RHEA:32069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + urate => 8-oxoguanine + H(+) + H2O
REACT:R-DRE-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Danio rerio)
RHEA:39626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)
REACT:R-GGA-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Gallus gallus)
REACT:R-BTA-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Bos taurus)
REACT:R-MMU-202165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)
REACT:R-RNO-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Rattus norvegicus)
RHEA:48272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-CFA-6791109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds PCNA (Canis familiaris)
RHEA:62883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 <=> (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A
REACT:R-CEL-8848247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD4,5 bind MCFA-CoA and LCFA-CoA (Caenorhabditis elegans)
REACT:R-MMU-9653595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B binds BCL2L1 (Mus musculus)
REACT:R-SCE-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Saccharomyces cerevisiae)
REACT:R-SCE-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Saccharomyces cerevisiae)
RHEA:53323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)
REACT:R-XTR-2152276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of transmembrane collagens (Xenopus tropicalis)
REACT:R-CFA-6805426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD8 binds CASP9(1-416) (Canis familiaris)
REACT:R-CFA-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Canis familiaris)
REACT:R-XTR-9701488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates JAK3 (Xenopus tropicalis)
REACT:R-BTA-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Bos taurus)
REACT:R-CFA-1433418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Canis familiaris)
REACT:R-CFA-983424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of COPII coated vesicle (Canis familiaris)
RHEA:25068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)
REACT:R-DRE-5654565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Danio rerio)
REACT:R-GGA-435244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM1 is phosphorylated (Gallus gallus)
REACT:R-RNO-4570485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO3 (Rattus norvegicus)
GO:0034533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity
REACT:R-DME-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Drosophila melanogaster)
RHEA:70081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + hydroxyclavatol + succinate => 2-oxoglutarate + clavatol + O2
RHEA:34078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl phosphate + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + phosphate
REACT:R-DRE-2179387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Danio rerio)
REACT:R-HSA-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Homo sapiens)
REACT:R-BTA-870437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
REACT:R-MMU-8948219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3 binds Lysyl hydroxylated collagen propeptides (Mus musculus)
REACT:R-CFA-202291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Lck (Canis familiaris)
REACT:R-SSC-2028679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Sus scrofa)
RHEA:15186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-arginine
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	signal-recognition-particle GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rho small monomeric GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ran small monomeric GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein-synthesizing GTPase activity, elongation
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	small monomeric GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein-synthesizing GTPase activity, initiation
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RHEB small monomeric GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heterotrimeric G-protein GTPase, beta-subunit
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rab small monomeric GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dynamin GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heterotrimeric G-protein GTPase, alpha-subunit
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Sar small monomeric GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ARF small monomeric GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heterotrimeric G-protein GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein-synthesizing GTPase activity, termination
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heterotrimeric G-protein GTPase, gamma-subunit
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ras small monomeric GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein-synthesizing GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tubulin GTPase activity
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTPase activity, coupled
GO:0003924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTPase activity
RHEA:42501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH
RHEA:58625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-dodecanoyl-(2S)-hydroxyglycine => dodecanamide + glyoxylate
RHEA:52202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => 1-aci-nitro-2-(phenyl)ethane + glutathione
RHEA:65282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+) => 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate
REACT:R-HSA-5358460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPE SHH variants don't undergo autoproteolytic cleavage (Homo sapiens)
RHEA:11347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylneuraminate + CTP <=> a CMP-N-acyl-beta-neuraminate + diphosphate
REACT:R-RNO-4085331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-1 SUMOylates PARK7 with SUMO1 (Rattus norvegicus)
RHEA:58560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate II + NADP(+) = 15alpha-stemmadenine intermediate I + NADPH
RHEA:38698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin(in) <=> a cardiolipin(out)
RHEA:27963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + pyrroloquinoline quinone => H(+) + pyrroloquinoline quinol + scyllo-inosose
RHEA:31611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene = H2O + rhodopin
REACT:R-DME-209049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of AXN and APC by SGG (Drosophila melanogaster)
RHEA:10137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glyoxylate + H(+) => 2-hydroxy-3-oxopropanoate + CO2
GO:0050044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactose-6-phosphate aldose-ketose-isomerase activity
GO:0050044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose-6-phosphate isomerase activity
GO:0050044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactose-6-phosphate ketol-isomerase activity
REACT:R-RNO-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Rattus norvegicus)
RHEA:56882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(5)-steroid + H(+) + NADPH => a 3beta-hydroxy-Delta(5)-steroid + NADP(+)
REACT:R-SSC-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Sus scrofa)
RHEA:71561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminomethyl-dUMP in DNA + AH2 + glyoxylate => 5-N(alpha)-glycyl-dTMP in DNA + A + H2O
REACT:R-HSA-2167876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7:SMURF2 complex translocates to the cytosol (Homo sapiens)
REACT:R-BTA-168849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAX protein (Bos taurus)
REACT:R-SSC-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Sus scrofa)
REACT:R-HSA-9636439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtpA:Ub dephosphorylates p-Y133-VPS33B (Homo sapiens)
REACT:R-DME-3222116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L3MBTL1 binds TP53 monomethylated on K382 (Drosophila melanogaster)
REACT:R-XTR-8848110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds activated PTK6 (Xenopus tropicalis)
GO:0033192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium- and calmodulin-dependent protein phosphatase activity
GO:0033192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium/calmodulin-dependent protein phosphatase activity
GO:0033192	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcineurin activity
GO:0033192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ca2+/CaM-dependent protein phosphatase activity
GO:0033192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calmodulin-dependent protein phosphatase activity
RHEA:24061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]
RHEA:20526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + ethylamine + L-glutamate => ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate
REACT:R-BTA-2046092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Bos taurus)
REACT:R-BTA-508162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Bos taurus)
REACT:R-HSA-162715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane (Homo sapiens)
RHEA:25264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2
REACT:R-XTR-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)
RHEA:66834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + preasperterpenoid A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate
RHEA:36639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine = 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine
RHEA:36639	skos:prefLabel	"3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase"
RHEA:36639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase"
RHEA:62541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain => dihydroouabain + 2 Fe(III)-[cytochrome c]
REACT:R-MMU-549322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations out of hepatic cells (Mus musculus)
REACT:R-SSC-71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Sus scrofa)
REACT:R-XTR-8964280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Gq binds BTK (Xenopus tropicalis)
REACT:R-HSA-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Homo sapiens)
RHEA:27323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:60068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)
REACT:R-HSA-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Homo sapiens)
REACT:R-DME-111751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
RHEA:55946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2-chloroethanol + 2 Fe(III)-[cytochrome c]
REACT:R-RNO-114307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SMAC (DIABLO) from mitochondria (Rattus norvegicus)
REACT:R-SSC-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Sus scrofa)
REACT:R-SSC-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Sus scrofa)
GO:0018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammelide aminohydrolase activity
REACT:R-HSA-74733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin receptor de-phosphorylation (Homo sapiens)
REACT:R-BTA-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Bos taurus)
REACT:R-MMU-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Mus musculus)
REACT:R-RNO-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Rattus norvegicus)
REACT:R-DME-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Drosophila melanogaster)
REACT:R-DME-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Drosophila melanogaster)
REACT:R-DRE-388808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-2 monomer (Danio rerio)
RHEA:10731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-6-deoxy-alpha-D-talose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH
GO:0004950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine receptor activity
RHEA:25318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> L-2-acetamido-6-oxoheptanedioate + L-glutamate
REACT:R-SCE-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Saccharomyces cerevisiae)
RHEA:68818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-alpha-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate
REACT:R-DRE-381487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP1 binds IGF forming IGF:IGFBP1 (Danio rerio)
GO:0047982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)
GO:0047982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homocysteine desulfurase activity
GO:0047982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homocysteine desulfhydrase activity
GO:0047982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-homocysteine hydrogen-sulfide-lyase (deaminating)
REACT:R-HSA-5654612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
RHEA:37683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
RHEA:65891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-hydroxy-L-kynurenine <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate
REACT:R-HSA-210913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEUROG3-dependent synthesis of INSM1 (Homo sapiens)
REACT:R-SPO-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Schizosaccharomyces pombe)
RHEA:50216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate
REACT:R-RNO-9648949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A antagonists bind HTR3A pentamer (Rattus norvegicus)
REACT:R-HSA-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Homo sapiens)
RHEA:29621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltopentaose + beta-D-glucose => alpha-maltotetraose + beta-maltose
GO:0016972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiol:oxygen oxidoreductase activity
GO:0016972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiol oxidase activity
GO:0016972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfhydryl oxidase activity
RHEA:32679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = (2E)-geraniol + diphosphate
RHEA:32679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranyl diphosphate diphosphatase"
RHEA:32679	skos:altLabel	"geraniol synthase"
RHEA:32679	skos:prefLabel	"geranyl diphosphate diphosphatase"
RHEA:32679	skos:altLabel	"geranyl pyrophosphate pyrophosphatase"
RHEA:47172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) = 5alpha-cholest-8-en-3-one + CO2 + NADH
REACT:R-XTR-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Xenopus tropicalis)
GO:0140259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 complex binding
REACT:R-RNO-5654157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR2 (Rattus norvegicus)
RHEA:50287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate
REACT:R-DME-193401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
RHEA:70639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-SSC-110221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by SMUG1 glycosylase (Sus scrofa)
REACT:R-CFA-9654523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP bind PDE6D on KRAS4B (Canis familiaris)
REACT:R-HSA-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Homo sapiens)
REACT:R-DRE-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Danio rerio)
REACT:R-RNO-1250357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds P-ERBB4 isoform dimers (Rattus norvegicus)
REACT:R-DME-209188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1-binding protein TAB2 binds to TAK1 kinase (Drosophila melanogaster)
RHEA:25552	skos:altLabel	"stemarene synthase"
RHEA:25552	skos:altLabel	"syn-stemar-13-ene synthase"
RHEA:25552	skos:prefLabel	"stemar-13-ene synthase"
RHEA:25552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate = diphosphate + stemar-13-ene
RHEA:25552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stemar-13-ene synthase"
RHEA:22696	skos:altLabel	"4-androstene-3,17-dione monooxygenase"
RHEA:22696	skos:altLabel	"androstene-3,17-dione hydroxylase"
RHEA:22696	skos:altLabel	"androstenedione monooxygenase"
RHEA:22696	skos:altLabel	"androst-4-ene-3,17-dione 17-oxidoreductase"
RHEA:22696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"androst-4-ene-3,17-dione monooxygenase"
RHEA:22696	skos:prefLabel	"androst-4-ene-3,17-dione monooxygenase"
RHEA:22696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone
REACT:R-SSC-9679775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT binds COMT Inhibitors (Sus scrofa)
GO:0018711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl acetate-CoA thiolase activity
RHEA:66127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-histidine <=> (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate
RHEA:57753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
REACT:R-RNO-9625487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates downstream of EGFR (Rattus norvegicus)
REACT:R-SSC-9607301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2 binds SOS1 (Sus scrofa)
RHEA:60410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O
RHEA:48312	skos:altLabel	"benzoyl-CoA 2,3-dioxygenase"
RHEA:48312	skos:prefLabel	"benzoyl-CoA 2,3-epoxidase"
RHEA:48312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + H(+) + NADPH + O2 = 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)
RHEA:48312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzoyl-CoA 2,3-epoxidase"
RHEA:48312	skos:altLabel	"benzoyl-CoA dioxygenase/reductase"
RHEA:15259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + glycine => D-threonine
RHEA:57149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
RHEA:42517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-gulono-1,4-lactone => H(+) + L-gulonate
RHEA:13407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide => 4-coumaroyl-CoA + agmatine
RHEA:53726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => ATP + N-acetyl-D-glucosamine
REACT:R-BTA-9617067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Bos taurus)
REACT:R-SSC-1678716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(1) (Sus scrofa)
RHEA:38173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecyl hexadecanoate + CoA => hexadecane-1,2-diol + hexadecanoyl-CoA
RHEA:46389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Drosophila melanogaster)
REACT:R-DME-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Drosophila melanogaster)
REACT:R-BTA-749446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Bos taurus)
REACT:R-CEL-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Caenorhabditis elegans)
REACT:R-DME-6811504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)
REACT:R-CFA-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Canis familiaris)
REACT:R-HSA-9670428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT mutants bind GRB2-SOS (Homo sapiens)
GO:0004828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	seryl-transfer RNA synthetase activity
GO:0004828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine translase activity
GO:0004828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-tRNA ligase activity
GO:0004828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	seryl-transfer ribonucleic acid synthetase activity
GO:0004828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SerRS activity
GO:0004828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine:tRNASer ligase (AMP-forming)
GO:0004828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	seryl-tRNA synthetase activity
GO:0004828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	seryl-transfer ribonucleate synthetase activity
REACT:R-HSA-844440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 activation by elicitor proteins (Homo sapiens)
REACT:R-HSA-193736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)
REACT:R-RNO-5655193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIAA0101 double monoubiquitination (Rattus norvegicus)
RHEA:12763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine => precorrin-3B + S-adenosyl-L-methionine
REACT:R-HSA-9674427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFR mutants bind type I TKIs (Homo sapiens)
RHEA:47949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine phosphate => phosphate + thiamine
RHEA:64846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl benzoate + CoA => (2E)-geraniol + benzoyl-CoA
RHEA:56659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH
RHEA:57560	skos:altLabel	"CYP76A26"
RHEA:57560	skos:prefLabel	"nepetalactol monooxygenase"
RHEA:57560	skos:altLabel	"iridoid oxidase"
RHEA:57560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nepetalactol monooxygenase"
RHEA:57560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-170977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 is phosphorylated by active TrkA receptor (Gallus gallus)
REACT:R-CFA-5623513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 stimulates GTPase activity of ARF4 (Canis familiaris)
REACT:R-DRE-6808566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHGA-derived peptide binds the bacterial cell surface (Danio rerio)
REACT:R-MMU-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Mus musculus)
REACT:R-RNO-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)
REACT:R-XTR-444476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPRL2 receptor binds a wide range of ligands (Xenopus tropicalis)
RHEA:70805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate => 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate
REACT:R-DME-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Drosophila melanogaster)
RHEA:55434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-420265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind IAPP(34-70) (Canis familiaris)
REACT:R-SSC-9709406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to Cytochrome c oxidase (Sus scrofa)
RHEA:54709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:34975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate(in) = (R)-pantothenate(out)
RHEA:69243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucoraphanin + H2O <=> (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
REACT:R-CFA-376357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp7 associated Lysosome to Plasma membrane transport (Canis familiaris)
REACT:R-XTR-5654515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds HS (Xenopus tropicalis)
REACT:R-RNO-381412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP2 binds IGF forming IGF:IGFBP2 (Rattus norvegicus)
REACT:R-HSA-8956427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RETSAT reduces atROL to at-13,14-dhROL (Homo sapiens)
REACT:R-DRE-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Danio rerio)
RHEA:21459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Rattus norvegicus)
RHEA:23419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-O-phospho-3-sulfolactate + H2O <=> (2R)-3-sulfolactate + phosphate
REACT:R-HSA-2046175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further sulfation on galactose residues produces KSPG (Homo sapiens)
RHEA:46204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanamide + CO2 + H2O => L-arginine + O2
REACT:R-MMU-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Mus musculus)
GO:0034793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopropanecarboxylate-CoA ligase activity
RHEA:34550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(II)yrinate + H2O + L-glutamine <=> ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate
REACT:R-CFA-9023884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to TGFA promoter (Canis familiaris)
REACT:R-HSA-9687384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)
RHEA:42640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine
GO:0031814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y4 nucleotide receptor binding
GO:0031814	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P2Y4 nucleotide receptor ligand
REACT:R-CEL-416358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) inhibits PI3K alpha (Caenorhabditis elegans)
RHEA:50142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
REACT:R-DDI-376369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp2 associated secretory vesicle to plasma membrane transport (Dictyostelium discoideum)
REACT:R-BTA-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)
RHEA:51681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + CTP => (2E,6E)-farnesyl phosphate + CDP + H(+)
RHEA:19437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate + UDP-alpha-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP
RHEA:19437	skos:prefLabel	"nicotinate glucosyltransferase"
RHEA:19437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinate glucosyltransferase"
REACT:R-RNO-5653936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Ragulator complex (Rattus norvegicus)
REACT:R-RNO-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-SSC-3364026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SET1 complex trimethylates H3K4 at the MYC gene (Sus scrofa)
REACT:R-RNO-140847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Rattus norvegicus)
REACT:R-RNO-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Rattus norvegicus)
RHEA:69984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-alk-1-en-1-SO-peroxol <=> (Z)-alkanethial oxide
RHEA:51774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlorisobutanophenone + diphosphate => dimethylallyl diphosphate + phlorisobutanophenone
RHEA:26258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroabietadienol + H(+) + NADPH + O2 => dehydroabietadienal + 2 H2O + NADP(+)
RHEA:56145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + nitrate => a quinone + H2O + nitrite
REACT:R-CFA-5591086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA5 binds activated protein C (Canis familiaris)
REACT:R-BTA-177671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Bos taurus)
EC:2.2.1.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-deoxy-6-sulfo-D-fructose transaldolase"
EC:2.2.1.14	skos:prefLabel	"6-deoxy-6-sulfo-D-fructose transaldolase"
RHEA:24254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate
EC:3.1.16.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spleen exonuclease"
EC:3.1.16.1	skos:altLabel	"spleen phosphodiesterase"
EC:3.1.16.1	skos:altLabel	"3'-exonuclease"
EC:3.1.16.1	skos:prefLabel	"spleen exonuclease"
REACT:R-BTA-265153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Bos taurus)
REACT:R-MMU-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Mus musculus)
RHEA:49951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2
REACT:R-HSA-9685681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs (Homo sapiens)
GO:0047366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 4'-sulfotransferase activity
GO:0047366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin-3-sulphate 4'-sulphotransferase activity
GO:0047366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity
GO:0047366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin-3-sulfate 4'-sulfotransferase activity
GO:0047366	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS:flavonol 3-sulfate 4'-sulfotransferase activity
RHEA:52675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate
RHEA:54015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
REACT:R-SSC-9638097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)
GO:0061812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic ADP-ribose hydrolase
REACT:R-RNO-8854759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D14 binds RAB11 and ULK1 (Rattus norvegicus)
REACT:R-CFA-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Canis familiaris)
RHEA:70697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + glycine(in) + 3 Na(+)(in) => chloride(out) + glycine(out) + 3 Na(+)(out)
REACT:R-GGA-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Gallus gallus)
RHEA:21148	skos:altLabel	"indol-3-ylacetyl-myo-inositol galactoside synthase"
RHEA:21148	skos:prefLabel	"indolylacetyl-myo-inositol galactosyltransferase"
RHEA:21148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP
RHEA:21148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indolylacetyl-myo-inositol galactosyltransferase"
RHEA:21148	skos:altLabel	"uridine diphosphogalactose-indolylacetylinositol galactosyltransferase"
REACT:R-DDI-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Dictyostelium discoideum)
REACT:R-SPO-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Schizosaccharomyces pombe)
RHEA:37996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-nonaprenyl diphosphate + H(+) + homogentisate => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate
RHEA:33698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C20 sphinganine + NADP(+) <=> 3-oxoeicosasphinganine + H(+) + NADPH
REACT:R-HSA-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
REACT:R-HSA-202212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to LAT (Homo sapiens)
REACT:R-CFA-8952625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Canis familiaris)
REACT:R-SSC-1295609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates SPRY2 on Y55 and Y227 (Sus scrofa)
RHEA:32668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methanethiol => H(+) + hydrogen sulfide + methyl-coenzyme M
RHEA:42099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamoyl phosphate + H2O + tobramycin <=> AMP + diphosphate + H(+) + nebramycin 5' + phosphate
GO:0047325	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1D-myo-inositol-trisphosphate 6-kinase activity
GO:0047325	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol-tetrakisphosphate 1-kinase activity
GO:0047325	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol-trisphosphate 6-kinase activity
GO:0047325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol tetrakisphosphate 1-kinase activity
GO:0047325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 3,4,5,6-tetrakisphosphate 1-kinase activity
GO:0047325	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity
GO:0047325	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol-trisphosphate 5-kinase activity
GO:0047325	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1D-myo-inositol-tetrakisphosphate 1-kinase activity
GO:0047325	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1D-myo-inositol-trisphosphate 5-kinase activity
RHEA:61889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diosgenin + UDP-alpha-D-glucose => diosgenin 3-O-beta-D-glucoside + H(+) + UDP
REACT:R-GGA-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Gallus gallus)
REACT:R-DME-6814096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds SCOC (Drosophila melanogaster)
REACT:R-PFA-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Plasmodium falciparum)
RHEA:48470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM1b (d18:1(4E)) + H2O
GO:0000155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorelay sensor kinase activity
GO:0000155	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	two-component sensor molecule
GO:0000155	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	two-component sensor activity
GO:0000155	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	two-component system sensor activity
REACT:R-XTR-186826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to the active receptor (Xenopus tropicalis)
REACT:R-DRE-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Danio rerio)
REACT:R-RNO-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Rattus norvegicus)
REACT:R-RNO-419981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Rattus norvegicus)
REACT:R-RNO-202453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Rattus norvegicus)
REACT:R-HSA-2731141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds fibronectin (Homo sapiens)
RHEA:23428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-DME-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Drosophila melanogaster)
RHEA:68269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + formaldehyde + H(+) + NADPH => dTMP + H2O + NADP(+)
REACT:R-DRE-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Danio rerio)
GO:0009672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	auxin:proton symporter activity
GO:0009672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	auxin:hydrogen symporter activity
RHEA:13905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP
RHEA:13905	skos:prefLabel	"lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase"
RHEA:13905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase"
REACT:R-CFA-109291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Canis familiaris)
REACT:R-GGA-879942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor is activated (Gallus gallus)
RHEA:35683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecasphinganine + NADP(+) = 3-oxohexadecasphinganine + H(+) + NADPH
RHEA:29091	skos:altLabel	"NADH-CoQ reductase"
RHEA:29091	skos:altLabel	"NADH-coenzyme Q reductase"
RHEA:29091	skos:altLabel	"NADH coenzyme Q1 reductase"
RHEA:29091	skos:altLabel	"reduced nicotinamide adenine dinucleotide-coenzyme Q reductase"
RHEA:29091	skos:altLabel	"dihydronicotinamide adenine dinucleotide-coenzyme Q reductase"
RHEA:29091	skos:altLabel	"NADH-ubiquinone oxidoreductase"
RHEA:29091	skos:altLabel	"electron transfer complex I"
RHEA:29091	skos:altLabel	"DPNH-ubiquinone reductase"
RHEA:29091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
RHEA:29091	skos:altLabel	"NADH-CoQ oxidoreductase"
RHEA:29091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADH:ubiquinone reductase (H(+)-translocating)"
RHEA:29091	skos:altLabel	"ubiquinone reductase"
RHEA:29091	skos:altLabel	"DPNH-coenzyme Q reductase"
RHEA:29091	skos:altLabel	"NADH dehydrogenase (ubiquinone)"
RHEA:29091	skos:altLabel	"mitochondrial electron transport complex 1"
RHEA:29091	skos:prefLabel	"NADH:ubiquinone reductase (H(+)-translocating)"
RHEA:29091	skos:altLabel	"coenzyme Q reductase"
RHEA:29091	skos:altLabel	"complex I (mitochondrial electron transport)"
RHEA:29091	skos:altLabel	"NADH-ubiquinone reductase"
RHEA:29091	skos:altLabel	"mitochondrial electron transport complex I"
RHEA:29091	skos:altLabel	"complex I (electron transport chain)"
RHEA:16847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate + CoA + H(+) => acetyl-CoA + H2O + oxaloacetate
REACT:R-PFA-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Plasmodium falciparum)
REACT:R-GGA-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Gallus gallus)
REACT:R-MMU-4420206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SRC-1 (Mus musculus)
RHEA:47355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hexanoate ester + H2O <=> an aliphatic alcohol + H(+) + hexanoate
RHEA:43457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA => (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:47839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[5-(aminomethyl)-3-furyl]methyl phosphate + ATP <=> [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP
RHEA:51884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline betaine = D-proline betaine
REACT:R-BTA-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Bos taurus)
REACT:R-RNO-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Rattus norvegicus)
REACT:R-RNO-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Rattus norvegicus)
REACT:R-CFA-77590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CstF to the CPSF Bound Pre-mRNA (Canis familiaris)
RHEA:23146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N-acetyl-D-glucosaminate + NADH => H2O + N-acetyl-alpha-D-glucosamine + NAD(+)
REACT:R-HSA-5688294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT5 deacetylates Cytochrome C (Homo sapiens)
GO:0002170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity IgA receptor activity
GO:0002170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity IgA receptor activity
REACT:R-DRE-374663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Ezrin (Danio rerio)
REACT:R-SSC-6786048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Sus scrofa)
GO:0004593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pantothenase activity
GO:0004593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-pantothenate amidohydrolase activity
GO:0004593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantothenate amidohydrolase activity
GO:0004593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantothenate hydrolase activity
REACT:R-RNO-2186607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
REACT:R-HSA-442405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hZIP5 mediates zinc uptake by cells (Homo sapiens)
REACT:R-HSA-6791363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates ARID3A gene expression (Homo sapiens)
GO:0048472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine-phosphate decarboxylase activity
GO:0048472	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine O-3-phosphate carboxy-lyase activity
GO:0048472	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobD
GO:0048472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine-O-3-phosphate decarboxylase activity
GO:0048472	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]
RHEA:67990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glutamine => N-acetyl-L-glutamine
REACT:R-SSC-1234183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Sus scrofa)
RHEA:57522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Drosophila melanogaster)
REACT:R-SCE-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Saccharomyces cerevisiae)
REACT:R-DRE-391905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxoeicosanoid receptor can bind oxoeicosanoid (Danio rerio)
REACT:R-BTA-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Bos taurus)
RHEA:49128	skos:prefLabel	"N-acetyl-demethylphosphinothricin P-methyltransferase"
RHEA:49128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyl-demethylphosphinothricin P-methyltransferase"
RHEA:49128	skos:altLabel	"P-methylase"
RHEA:49128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine
REACT:R-DME-1606583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Drosophila melanogaster)
REACT:R-XTR-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Xenopus tropicalis)
REACT:R-DRE-4088141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PPP2R2A dephosphorylates FOXM1 (Danio rerio)
REACT:R-SSC-77613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR2 homodimer to dsRNA duplex (Sus scrofa)
REACT:R-XTR-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Xenopus tropicalis)
REACT:R-BTA-9634702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Bos taurus)
RHEA:14437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-lysine oxidase"
RHEA:14437	skos:prefLabel	"L-lysine oxidase"
RHEA:14437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)
RHEA:15842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + NADP(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
RHEA:29753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(out) => acetoacetate(in)
RHEA:58329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-non-6-en-1-ol + NADP(+) => (Z)-non-6-enal + H(+) + NADPH
RHEA:13892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H2O <=> AMP + FMN + 2 H(+)
REACT:R-DRE-9678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 binds S1PR1 agonists (Danio rerio)
RHEA:19202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + ATP => ADP + dGMP + H(+)
REACT:R-HSA-5672957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates KSR1 (Homo sapiens)
REACT:R-SSC-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
GO:0034015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SgaU
GO:0034015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UlaE
GO:0034015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose-5-phosphate 3-epimerase activity
GO:0034015	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-xylulose 5-phosphate 3-epimerase activity
REACT:R-RNO-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Rattus norvegicus)
GO:0033904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DL 2
GO:0033904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,6-glucan-6-glucanohydrolase activity
GO:0033904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endodextranase activity
GO:0033904	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dextranase DL 2 activity
GO:0033904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-dextranase activity
GO:0033904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dextranase activity
GO:0033904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-1,6-glucan-6-glucanohydrolase activity
GO:0033904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,6-alpha-D-glucan 6-glucanohydrolase activity
GO:0033904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextran hydrolase activity
GO:0047801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine transaminase activity
GO:0047801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine:2-oxoglutarate aminotransferase activity
GO:0047801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine transaminase activity
GO:0047801	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cysteine aminotransferase activity
REACT:R-SPO-83788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to Type 2 promoter (Schizosaccharomyces pombe)
RHEA:20846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + oxaloacetate + phosphate => ATP + hydrogencarbonate + pyruvate
RHEA:40297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + hexadecanedioyl-CoA => ATP + CoA + hexadecanedioate
REACT:R-SSC-5687465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds RBBP8 (Sus scrofa)
REACT:R-GGA-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Gallus gallus)
REACT:R-SPO-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Schizosaccharomyces pombe)
RHEA:27430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate
RHEA:11235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + sulfate
REACT:R-SPO-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Schizosaccharomyces pombe)
REACT:R-GGA-451056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Microtubule-independent trafficking of connexons to the plasma membrane (Gallus gallus)
REACT:R-MMU-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Mus musculus)
REACT:R-BTA-8866941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MID1IP1 binds THRSP (Bos taurus)
GO:0016669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor
GO:0016669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor
GO:0016669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a cytochrome as acceptor"
GO:0016669	skos:prefLabel	"With a cytochrome as acceptor"
RHEA:55786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP => all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate
GO:0010997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anaphase-promoting complex binding
GO:0010997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC binding
REACT:R-RNO-3640858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase ADP-ribosylates AXIN (Rattus norvegicus)
REACT:R-HSA-8854981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 in the RET complex is phosphorylated (Homo sapiens)
REACT:R-CFA-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)
REACT:R-DRE-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Danio rerio)
REACT:R-MMU-9038029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxysterol binds ESR1, ESR2 (Mus musculus)
REACT:R-XTR-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Xenopus tropicalis)
REACT:R-HSA-4720446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)
RHEA:52540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine
REACT:R-DDI-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Dictyostelium discoideum)
RHEA:56850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + reumycin + S-adenosyl-L-homocysteine => 1,6-didemethyltoxoflavin + S-adenosyl-L-methionine
REACT:R-MMU-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Mus musculus)
REACT:R-BTA-2168046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XII degradation by MMP12 (Bos taurus)
REACT:R-CEL-390595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Troponin-C (Caenorhabditis elegans)
EC:3.2.1.146	skos:altLabel	"exo-beta-galactofuranosidase"
EC:3.2.1.146	skos:altLabel	"exo-beta-D-galactofuranosidase"
EC:3.2.1.146	skos:prefLabel	"beta-galactofuranosidase"
EC:3.2.1.146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-galactofuranosidase"
EC:3.2.1.146	skos:altLabel	"beta-D-galactofuranosidase"
REACT:R-BTA-9706328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS2 (Bos taurus)
REACT:R-HSA-9012036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)
REACT:R-BTA-432897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ILK interacts with beta-1 integrin (Bos taurus)
RHEA:47303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:51036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = 2 H2O + indole-3-pyruvate imine dimer
RHEA:41749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)
RHEA:47589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) => CMP + ganglioside GQ1c (d18:1(4E)) + H(+)
EC:1.14.14.42	skos:prefLabel	"homomethionine N-monooxygenase"
EC:1.14.14.42	skos:altLabel	"CYP79F1"
EC:1.14.14.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homomethionine N-monooxygenase"
REACT:R-RNO-2214324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII dimerization (Rattus norvegicus)
REACT:R-HSA-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Homo sapiens)
REACT:R-HSA-6793958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of STAT6-upregulated plasma membrane proteins (Homo sapiens)
RHEA:72659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + quinolin-8-ol = 8-hydroxyquinoline N-oxide + H2O + NADP(+)
REACT:R-SSC-2213192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemidesmosome formation (Sus scrofa)
RHEA:24482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O
REACT:R-BTA-6814695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PERP binds desmosomes (Bos taurus)
RHEA:39182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-eicosenoyl-CoA + H(+) + NADPH <=> eicosanoyl-CoA + NADP(+)
GO:0047517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity
GO:0047517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-xylan synthase activity
GO:0047517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity
GO:0047517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylan synthase activity
GO:0047517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-beta-D-xylan synthase activity
GO:0047517	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylan synthetase activity
RHEA:21999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA
REACT:R-CEL-9692738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds HRH2 antagonists (Caenorhabditis elegans)
RHEA:39889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:41466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-190258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c binds to FGF (Rattus norvegicus)
REACT:R-CFA-5694427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA3 binds procollagen VII (Canis familiaris)
RHEA:59509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + L-cysteinyl-[protein] => S-(2-succinyl)-L-cysteinyl-[protein]
REACT:R-HSA-349520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-acidification of acetylcholine transport vesicles (Homo sapiens)
REACT:R-DDI-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Dictyostelium discoideum)
RHEA:69992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + NADP(+) => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH
REACT:R-HSA-9729841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 nsp8 binds to 7SL RNA (Homo sapiens)
REACT:R-XTR-4084978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Xenopus tropicalis)
REACT:R-XTR-5617143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)
REACT:R-GGA-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Gallus gallus)
RHEA:13509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine
RHEA:13509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine diphosphorylase"
RHEA:13509	skos:altLabel	"UDP-N-acetylglucosamine pyrophosphorylase"
RHEA:13509	skos:altLabel	"N-acetylglucosamine-1-phosphate uridyltransferase"
RHEA:13509	skos:prefLabel	"UDP-N-acetylglucosamine diphosphorylase"
REACT:R-CFA-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
REACT:R-MMU-9615249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBs bind AGRT1 (Mus musculus)
RHEA:65965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurocholate(out) => ADP + H(+) + phosphate + taurocholate(in)
RHEA:30862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dITP + H2O <=> dIDP + H(+) + phosphate
REACT:R-RNO-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
REACT:R-BTA-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Bos taurus)
REACT:R-RNO-5688289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Rattus norvegicus)
REACT:R-CFA-2327909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN binds collagen I, II, III, VI fibrils (Canis familiaris)
RHEA:31468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-glucosyl) crocetin + UDP
REACT:R-CEL-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Caenorhabditis elegans)
REACT:R-HSA-9670054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defects in F8 A2 domain accelerate dissociation of the A2 domain (Homo sapiens)
REACT:R-RNO-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Rattus norvegicus)
REACT:R-RNO-9756162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 4-OH-ATV (Rattus norvegicus)
REACT:R-MMU-2396561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)
RHEA:49522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2
RHEA:31366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) <=> 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-BTA-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Bos taurus)
REACT:R-MMU-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Mus musculus)
REACT:R-BTA-2168886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemopexin binds Hemes (Bos taurus)
RHEA:50541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin A2 => prostaglandin C2
RHEA:53086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose
REACT:R-XTR-433101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Xenopus tropicalis)
RHEA:67379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-histidine + H2O <=> glycine + L-histidine
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MLCK
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	smooth-muscle-myosin-light-chain kinase activity
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin kinase activity
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin light-chain kinase (phosphorylating) activity
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	calcium/calmodulin-dependent myosin light chain kinase activity
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK18
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin light chain protein kinase activity
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MLCkase activity
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin light-chain kinase activity
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP:myosin-light-chain O-phosphotransferase
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:myosin-light-chain O-phosphotransferase activity
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin-light-chain kinase activity
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	myosin light-chain kinase
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin light chain kinase activity
GO:0004687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin light-chain kinase (phosphorylating)
REACT:R-MMU-165162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TSC2 by PKB (Mus musculus)
REACT:R-SSC-201631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 3 (Sus scrofa)
REACT:R-HSA-4411351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF/LEF:CTNNB1 bind the AXIN2 gene (Homo sapiens)
REACT:R-XTR-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Xenopus tropicalis)
RHEA:40097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexacosanedioate + NADH => 26-oxohexacosanoate + H2O + NAD(+)
REACT:R-SSC-2161187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Sus scrofa)
RHEA:36412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + hnu => calciol
RHEA:27366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + S-adenosyl-L-methionine => bromomethane + S-adenosyl-L-homocysteine
REACT:R-HSA-1169398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host protein filamin B (Homo sapiens)
REACT:R-GGA-8855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR binds DAB1 (Gallus gallus)
REACT:R-SSC-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Sus scrofa)
RHEA:45480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-hexachlorocyclohexane = (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)
REACT:R-SSC-5625745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 stimulates association of AR with NCOA2 (Sus scrofa)
REACT:R-HSA-982807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation of GHR (Homo sapiens)
RHEA:66116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-glutamine = (2S)-2-aminobutanoate + 2-oxoglutaramate
REACT:R-DDI-2294580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 hyperphosphorylates Condensin II complex (Dictyostelium discoideum)
RHEA:54050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-MMU-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Mus musculus)
RHEA:65247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hesperetin + UDP-alpha-D-glucose <=> (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-DME-446877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is K63 poly-ubiquitinated (Drosophila melanogaster)
REACT:R-CEL-3928654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin internalises EPH:EFN complexes (Caenorhabditis elegans)
REACT:R-HSA-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Homo sapiens)
RHEA:55167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 <=> H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)
REACT:R-XTR-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Xenopus tropicalis)
RHEA:60938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:50880	skos:prefLabel	"teichoic acid glycerol-phosphate transferase"
RHEA:50880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol = 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)
RHEA:50880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"teichoic acid glycerol-phosphate transferase"
RHEA:50880	skos:altLabel	"teichoic acid glycerol-phosphate primase"
RHEA:26125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + L-proline => (S)-1-pyrroline-5-carboxylate + FADH2
REACT:R-XTR-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Xenopus tropicalis)
REACT:R-SSC-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)
REACT:R-CFA-390281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Canis familiaris)
REACT:R-CFA-9023627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)
REACT:R-DME-937032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 (Drosophila melanogaster)
RHEA:28140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	streptothricin F acid => H2O + streptothricin F
RHEA:19268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH
GO:0047297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine-keto acid aminotransferase activity
GO:0047297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagine-oxo-acid aminotransferase activity
GO:0047297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine--oxo-acid aminotransferase activity
GO:0047297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagine-oxo-acid transaminase activity
GO:0047297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-asparagine:2-oxo-acid aminotransferase activity
REACT:R-MMU-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Mus musculus)
GO:0102496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GA5 2,3 epoxidase activity
REACT:R-DDI-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Dictyostelium discoideum)
REACT:R-MMU-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Mus musculus)
GO:0102780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sitosterol hydroxylase activity
REACT:R-GGA-5686286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Gallus gallus)
REACT:R-SSC-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Sus scrofa)
RHEA:72381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + iodide(out) => chloride(out) + iodide(in)
RHEA:11471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + L-valine <=> 3-methyl-2-oxobutanoate + L-isoleucine
REACT:R-DDI-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Dictyostelium discoideum)
RHEA:52515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + trans-4-hydroxy-L-proline <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
REACT:R-MTU-964912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP from Ery4P and PEP (Mycobacterium tuberculosis)
RHEA:65191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + berkeleyone B + O2 <=> berkeleydione + CO2 + H2O + succinate
REACT:R-BTA-1678998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosomal TLRs pass through the Golgi (Bos taurus)
RHEA:39119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2
REACT:R-CEL-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Caenorhabditis elegans)
RHEA:56259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP
REACT:R-MMU-8874201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L3 (Mus musculus)
RHEA:12606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H(+) + pyruvate => 1-deoxy-D-xylulose 5-phosphate + CO2
REACT:R-BTA-388828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PD-1 binds B7DC and B7H1 (Bos taurus)
REACT:R-XTR-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Xenopus tropicalis)
RHEA:50379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ceramide(in) + ATP + H2O <=> a ceramide(out) + ADP + H(+) + phosphate
GO:0015108	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	chloride transporting ATPase activity
GO:0015108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region (Homo sapiens)
GO:0015108	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	chloride-transporting ATPase activity
GO:0015108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride transmembrane transporter activity
GO:0015108	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP-dependent chloride transmembrane transporter activity
GO:0015108	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATPase-coupled chloride transmembrane transporter activity
GO:0015108	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	chloride ABC transporter
GO:0015108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride ion transmembrane transporter activity
GO:0033738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate:ferredoxin oxidoreductase activity
GO:0033738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydrofolate reductase (ferredoxin) activity
GO:0033738	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	5,10-methylenetetrahydrofolate reductase activity
RHEA:62257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(out) + 2 hydrogencarbonate(out) => Cd(2+)(in) + 2 hydrogencarbonate(in)
REACT:R-RNO-5687675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates remaining SSBs in MMEJ (Rattus norvegicus)
EC:1.8.-.-	skos:prefLabel	"Acting on a sulfur group of donors"
EC:1.8.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on a sulfur group of donors"
REACT:R-CFA-400183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA:RXRA binds Corepressors of PPARA (Canis familiaris)
GO:0005080	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein kinase C alpha binding
GO:0005080	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein kinase C delta binding
GO:0005080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC eta binding
GO:0005080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC binding
GO:0005080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase C binding
GO:0005080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC delta binding
GO:0005080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC alpha binding
GO:0005080	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein kinase C eta binding
GO:0050350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trihydroxystilbene synthase activity
GO:0050350	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	stilbene synthase activity
GO:0050350	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
GO:0050350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	resveratrol synthase activity
REACT:R-HSA-6805638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A acetylates TP53 (Homo sapiens)
REACT:R-SSC-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Sus scrofa)
RHEA:61143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + myricetin + succinate
RHEA:29849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA
REACT:R-GGA-191830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP nuclear import and release (Gallus gallus)
RHEA:72295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate(out) + 3 Na(+)(out) = malate(in) + 3 Na(+)(in)
REACT:R-BTA-4755478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates IKBKE with SUMO1 (Bos taurus)
REACT:R-XTR-2066788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Xenopus tropicalis)
REACT:R-CFA-451757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of nephrin and KIRREL2, KIRREL3 (Canis familiaris)
RHEA:34533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose
REACT:R-XTR-5654224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds PLCG1 (Xenopus tropicalis)
REACT:R-CFA-5654423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Canis familiaris)
RHEA:61426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-cis-nepetalactone + H(+) + NADH => cis-cis-nepetalactol + NAD(+)
GO:0004162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylnitrosamine demethylase activity
GO:0004162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-nitrosodimethylamine demethylase activity
RHEA:69737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylsuccinyl-CoA + succinate => phenylsuccinate + succinyl-CoA
REACT:R-BTA-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Bos taurus)
REACT:R-XTR-9034053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Xenopus tropicalis)
REACT:R-HSA-202703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD47 binds SIRP (Homo sapiens)
REACT:R-HSA-5624952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the retrograde IFT train (Homo sapiens)
RHEA:47909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)
REACT:R-GGA-434018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of chicken IRAK4 (Gallus gallus)
REACT:R-CFA-443978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR11 binds CCL19, CCL21 & CCL25 (Canis familiaris)
REACT:R-DME-193789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Drosophila melanogaster)
RHEA:68167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]
GO:0102950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-valine synthetase activity
GO:0102387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamyl alcohol + acetyl-CoA = (E)-cinnamyl acetate + CoA
GO:0102387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + benzyl alcohol = benzyl acetate + CoA
GO:0102387	skos:prefLabel	"acetyl-CoA-benzylalcohol acetyltransferase"
GO:0102387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetyl-CoA-benzylalcohol acetyltransferase"
GO:0102387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethanol acetyltransferase activity
REACT:R-DME-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Drosophila melanogaster)
RHEA:56251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]
REACT:R-BTA-8964340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq-BTK complex dissociates to Active BTK and Gq (Bos taurus)
REACT:R-HSA-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Homo sapiens)
REACT:R-CFA-2167942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII ectodomain shedding (Canis familiaris)
RHEA:51608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate
RHEA:72045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(out) + orotate(in) => L-glutamate(in) + orotate(out)
RHEA:49353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:13715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + fumarate => a ubiquinone + succinate
RHEA:58208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydroalstonine = AH2 + alstonine
RHEA:56526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + heme d1 => A + dihydro-heme d1
REACT:R-SPO-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Schizosaccharomyces pombe)
REACT:R-BTA-3000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BORA binds SCF-beta-TrCp1/2 (Bos taurus)
REACT:R-RNO-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)
REACT:R-SSC-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Sus scrofa)
REACT:R-HSA-3134896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRR FLII-interacting protein 1 binds dsDNA (Homo sapiens)
REACT:R-HSA-430190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds NCK (Homo sapiens)
REACT:R-RNO-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Rattus norvegicus)
REACT:R-DDI-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Dictyostelium discoideum)
REACT:R-DRE-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Danio rerio)
REACT:R-BTA-2730841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV (Bos taurus)
REACT:R-RNO-164840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP and Pi bind to ATPase (Rattus norvegicus)
GO:0072341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid derivative binding
GO:0072341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	modified amino acid binding
REACT:R-HSA-9645137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activator phosphorylates STAT5 (Homo sapiens)
RHEA:57334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite => H2O + 3 O2 + 3 propionate 3-nitronate
RHEA:29601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase] => monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-5654620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)
REACT:R-SSC-6800198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Sus scrofa)
RHEA:30340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-tryptophan => CO2 + tryptamine
RHEA:62081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-sulfate + NADP(+) => 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH
REACT:R-XTR-77327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Xenopus tropicalis)
REACT:R-MMU-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Mus musculus)
RHEA:10138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxopropanoate + CO2 => 2 glyoxylate + H(+)
REACT:R-CFA-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Canis familiaris)
RHEA:68905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + ATP + H(+) + NADPH => 3-phenylpropanal + AMP + diphosphate + NADP(+)
REACT:R-DME-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Drosophila melanogaster)
REACT:R-DME-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Drosophila melanogaster)
REACT:R-DDI-508308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Dictyostelium discoideum)
REACT:R-XTR-9609310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β-blockers bind ADRB1,2,3 (Xenopus tropicalis)
REACT:R-BTA-1614460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of procollagen type VI (Bos taurus)
REACT:R-BTA-8944247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VI (Bos taurus)
RHEA:33750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + ATP <=> a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-MMU-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Mus musculus)
RHEA:63149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-taurine => (9Z)-octadecenoate + taurine
REACT:R-SSC-9661419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds extracellular heme (Sus scrofa)
RHEA:69507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine + O2 <=> H2O2 + N-acetyl-D-glucosamino-1,5-lactone
GO:0018850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
GO:0018850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloromuconate cycloisomerase activity
GO:0018850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	muconate cycloisomerase II activity
REACT:R-RNO-158399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein binds SERPING1 (Rattus norvegicus)
REACT:R-DRE-6807875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Danio rerio)
REACT:R-MMU-1602368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Mus musculus)
REACT:R-RNO-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Rattus norvegicus)
REACT:R-XTR-9709454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR binds EPOR agonists (Xenopus tropicalis)
RHEA:61566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2
RHEA:58670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyglucosone + H(+) + NADPH => 3-deoxyfructose + NADP(+)
RHEA:53596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycerol + phosphate
RHEA:30920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + rhodopin => (3E)-3,4-didehydrorhodopin + AH2
REACT:R-RNO-9632868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1B is phosphorylated in response to estrogen (Rattus norvegicus)
RHEA:43346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+)
REACT:R-HSA-8865090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)
REACT:R-SSC-8864125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Sus scrofa)
REACT:R-DDI-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-GGA-5654607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PPTN11 (Gallus gallus)
REACT:R-SSC-3928645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB:NMDAR binds TIAM1 (Sus scrofa)
RHEA:41305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + dodecanoate => H2O + N-dodecanoyl-(4R)-hydroxysphinganine
RHEA:24405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA => acetoacetate + acetyl-CoA
REACT:R-RNO-176101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Rad17-RFC complex to DNA (Rattus norvegicus)
RHEA:46934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-epi-valiolone 7-phosphate => 2-epi-5-epi-valiolone 7-phosphate
REACT:R-CFA-4755524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1I2 with SUMO3 (Canis familiaris)
REACT:R-PFA-8961021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD binds with itself to form SFTPD 12mer (Plasmodium falciparum)
GO:0061463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-ADP-ribose deacetylase activity
RHEA:39849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+) => a 2-acylglycerol + ATP
RHEA:71256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + phosphate(out) => 3 Na(+)(in) + phosphate(in)
REACT:R-DRE-210300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and TREM2 (Danio rerio)
REACT:R-SCE-194718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Saccharomyces cerevisiae)
REACT:R-SCE-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Saccharomyces cerevisiae)
RHEA:61390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + biotin(out) + H(+) + phosphate => ATP + biotin(in) + H2O
REACT:R-DRE-5690046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT2 hydrolyses PALMCoA to PALM (Danio rerio)
RHEA:38286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	itaconate + succinyl-CoA <=> itaconyl-CoA + succinate
GO:0031893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vasopressin receptor binding
GO:0031893	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vasopressin receptor ligand
RHEA:68367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol <=> 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)
REACT:R-MMU-9012036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)
RHEA:57443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] <=> 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
REACT:R-SSC-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Sus scrofa)
REACT:R-CFA-8950448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Canis familiaris)
REACT:R-XTR-9028730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FRS2 (Xenopus tropicalis)
RHEA:12154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+) => (3R,4S,5S,6R)-pentachlorocyclohexene
REACT:R-GGA-2197698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src phosphorylate WASP,N-WASP (Gallus gallus)
RHEA:26160	skos:prefLabel	"thalianol synthase"
RHEA:26160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thalianol synthase"
RHEA:26160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = thalianol
REACT:R-RNO-8848606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates PXN (Rattus norvegicus)
REACT:R-HSA-5607742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Homo sapiens)
REACT:R-GGA-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Gallus gallus)
RHEA:14687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + an aldehyde => A + a primary alcohol
REACT:R-GGA-917891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Gallus gallus)
REACT:R-XTR-193491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Xenopus tropicalis)
REACT:R-DDI-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Dictyostelium discoideum)
REACT:R-DDI-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Dictyostelium discoideum)
RHEA:49575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + 2 H(+) <=> coproporphyrin III + Fe(2+)
RHEA:68172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 = CO2 + H2O + isodomoate A + succinate
RHEA:14734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ag(+)(in) + ATP + H2O => ADP + Ag(+)(out) + H(+) + phosphate
RHEA:11313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrazine + H2O => chloride + H(+) + hydroxyatrazine
GO:0017136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone deacetylase activity
GO:0017136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SIR2
REACT:R-DME-3076905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular BTD hydrolyses BCTN (Drosophila melanogaster)
REACT:R-HSA-202489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of Bcl10 (Homo sapiens)
REACT:R-GGA-8848993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated KHDRBS1 translocates to the cytosol (Gallus gallus)
REACT:R-SCE-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)
REACT:R-SCE-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Saccharomyces cerevisiae)
RHEA:42387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4'-diaponeurosporenal + H2O + NAD(+) <=> 4,4'-diaponeurosporenoate + 2 H(+) + NADH
REACT:R-HSA-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Homo sapiens)
REACT:R-BTA-5357904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Bos taurus)
REACT:R-RNO-6795460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK1 phosphorylates MDM2 (Rattus norvegicus)
REACT:R-RNO-9645524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose binds TIFA (Rattus norvegicus)
GO:0004990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxytocin receptor activity
REACT:R-DME-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Drosophila melanogaster)
RHEA:37252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteamine S-phosphate + H2O => cysteamine + phosphate
RHEA:43785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine
RHEA:48370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose
REACT:R-SSC-8949580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F1Fo ATP synthase dimerizes (Sus scrofa)
REACT:R-PFA-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)
REACT:R-MMU-5607747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MALT1 oligomers (Mus musculus)
REACT:R-DRE-8984023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Danio rerio)
REACT:R-DDI-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Dictyostelium discoideum)
RHEA:20774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + riboflavin => 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+)
RHEA:63631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hexadecanoate + holo-[ACP] <=> AMP + diphosphate + hexadecanoyl-[ACP]
RHEA:22979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate
REACT:R-XTR-140777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Xenopus tropicalis)
REACT:R-SSC-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Sus scrofa)
RHEA:48677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Xenopus tropicalis)
REACT:R-SSC-2248891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARSA translocates to the lysosome (Sus scrofa)
REACT:R-RNO-4088134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates FOXM1 (Rattus norvegicus)
RHEA:17324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + S-adenosyl-L-methionine <=> 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine
RHEA:46702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoyl-GMP + diphosphate => (R)-lipoate + GTP + H(+)
REACT:R-CEL-77345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)
REACT:R-DRE-8878056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds EP300 (Danio rerio)
RHEA:61381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O => 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate
RHEA:10156	skos:prefLabel	"dihydrochelirubine 12-monooxygenase"
RHEA:10156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrochelirubine 12-monooxygenase"
RHEA:10156	skos:altLabel	"dihydrochelirubine 12-hydroxylase"
RHEA:10156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:15315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NH4(+) => ethanolamine
REACT:R-MMU-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)
RHEA:29488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => cis-muurola-3,5-diene + diphosphate
GO:0015925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosidase activity
RHEA:39680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA
REACT:R-DRE-5696872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates Ub-MOM proteins (Danio rerio)
REACT:R-SPO-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Schizosaccharomyces pombe)
RHEA:50266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)
REACT:R-GGA-430311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rsu-1 interacts with Pinch1 (Gallus gallus)
REACT:R-RNO-448963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of MyoD:E protein with MEF2 (Rattus norvegicus)
REACT:R-MMU-6814682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of early-endosome derived vesicles at the TGN (Mus musculus)
RHEA:39841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + CoA => a 2,3-diacyl-sn-glycerol + an acyl-CoA
REACT:R-BTA-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Bos taurus)
REACT:R-RNO-73739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)
REACT:R-RNO-187035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-beta-NGF and mature beta-NGF are secreted (Rattus norvegicus)
RHEA:66492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
RHEA:31454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> a cardiolipin + glycerol
REACT:R-HSA-197268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)
GO:0140594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity
RHEA:70568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-SSC-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Sus scrofa)
RHEA:11516	skos:altLabel	"succinyl-CoA acylase"
RHEA:11516	skos:prefLabel	"succinyl-CoA hydrolase"
RHEA:11516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + succinyl-CoA = CoA + H(+) + succinate
RHEA:11516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinyl-CoA hydrolase"
RHEA:36791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(omega)-hydroxy-L-arginine amidinohydrolase"
RHEA:36791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-hydroxy-L-arginine = hydroxyurea + L-ornithine
RHEA:36791	skos:prefLabel	"N(omega)-hydroxy-L-arginine amidinohydrolase"
RHEA:53370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NADP(+)
RHEA:72743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene C4(out) = leukotriene C4(in)
REACT:R-HSA-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Homo sapiens)
REACT:R-CFA-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Canis familiaris)
REACT:R-CEL-70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)
GO:0000400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Holliday junction binding
GO:0000400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	four-way junction DNA binding
GO:0000400	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	forked DNA binding
RHEA:34897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + selenite(in) => ATP + H2O + selenite(out)
REACT:R-DRE-71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer reduces PYR to LACT (Danio rerio)
REACT:R-SSC-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Sus scrofa)
REACT:R-DME-3858489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds DAAM1 (Drosophila melanogaster)
REACT:R-RNO-73931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Rattus norvegicus)
GO:0015169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate transmembrane transporter activity
REACT:R-BTA-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Bos taurus)
REACT:R-SSC-114392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Sus scrofa)
RHEA:17006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucuronate => 1-phospho-alpha-D-glucuronate + ADP + H(+)
RHEA:57741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated meromycolyl-[ACP] + NAD(+) => a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH
REACT:R-SCE-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Saccharomyces cerevisiae)
REACT:R-SSC-8869694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds CD14 (Sus scrofa)
REACT:R-CFA-163096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Telomerase RNP to the Telomeric Chromosome End (Canis familiaris)
RHEA:28467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine(in) => pyridoxamine(out)
REACT:R-CEL-159046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Caenorhabditis elegans)
RHEA:29655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(in) = L-cysteine(out)
EC:3.4.14.4	skos:altLabel	"dipeptidyl arylamidase III"
EC:3.4.14.4	skos:altLabel	"red cell angiotensinase"
EC:3.4.14.4	skos:altLabel	"dipeptidyl aminopeptidase III"
EC:3.4.14.4	skos:altLabel	"enkephalinase B"
EC:3.4.14.4	skos:prefLabel	"dipeptidyl-peptidase III"
EC:3.4.14.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dipeptidyl-peptidase III"
EC:3.4.14.4	skos:altLabel	"DPP III"
REACT:R-SPO-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Schizosaccharomyces pombe)
REACT:R-DRE-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Danio rerio)
EC:1.12.1.5	skos:prefLabel	"hydrogen dehydrogenase [NAD(P)(+)]"
EC:1.12.1.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrogen dehydrogenase [NAD(P)(+)]"
REACT:R-CFA-390427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Canis familiaris)
REACT:R-RNO-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Rattus norvegicus)
RHEA:15937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH
REACT:R-CFA-378975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follitropin is a heterodimer (Canis familiaris)
REACT:R-CFA-1169192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B dephosphorylates GHR (Canis familiaris)
REACT:R-DDI-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Dictyostelium discoideum)
REACT:R-SSC-202510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1-TAB2 complex (Sus scrofa)
RHEA:46258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-GGA-8875490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind ubiquitinated MET (Gallus gallus)
REACT:R-SPO-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Schizosaccharomyces pombe)
RHEA:50075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + tauroursodeoxycholate(in) <=> ADP + H(+) + phosphate + tauroursodeoxycholate(out)
REACT:R-BTA-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Bos taurus)
REACT:R-GGA-6814675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Gallus gallus)
RHEA:50492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]
REACT:R-DRE-141310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Danio rerio)
RHEA:29251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
RHEA:53069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxyestrone + UDP-alpha-D-glucuronate => 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-MMU-2076220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
RHEA:69546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-adenylylstreptidine + diphosphate => ATP + streptidine
REACT:R-XTR-177927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to EGF:EGFR:GRB2:GAB1 (Xenopus tropicalis)
REACT:R-SSC-77615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR2) (Sus scrofa)
RHEA:54066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:13078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl phosphate + D-hexose => a carboxylate + D-hexose phosphate + H(+)
RHEA:23760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:23760	skos:prefLabel	"coenzyme F420 hydrogenase"
RHEA:23760	skos:altLabel	"F420-reducing hydrogenase"
RHEA:23760	skos:altLabel	"coenzyme F420-dependent hydrogenase"
RHEA:23760	skos:altLabel	"8-hydroxy-5-deazaflavin-reducing hydrogenase"
RHEA:23760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coenzyme F420 hydrogenase"
REACT:R-GGA-388809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTLA-4 binds B7-1/B7-2 (Gallus gallus)
RHEA:44495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
RHEA:19142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol => 11-cis-retinol
REACT:R-SSC-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Sus scrofa)
RHEA:27552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate => di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate
REACT:R-CFA-1678923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR folding by chaperones GP96 and CNPY3 (Canis familiaris)
REACT:R-MMU-9708430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 (CRM1) binds to BACH1:Hemes (Mus musculus)
RHEA:69235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hydroxypropyl glucosinolate + H2O <=> (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
GO:0047721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoleacetate-lysine ligase activity
GO:0047721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(indole-3-acetyl)-L-lysine synthetase activity
GO:0047721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoleacetate-lysine synthetase activity
GO:0047721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IAA-lysine synthetase activity
GO:0047721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(indol-3-yl)acetate:L-lysine ligase (ADP-forming)
GO:0047721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleacetate:L-lysine ligase (ADP-forming)
REACT:R-HSA-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Homo sapiens)
REACT:R-HSA-1912372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fringe-modified Pre-NOTCH is cleaved by FURIN (Homo sapiens)
RHEA:67966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-L-phenylalanine + S-adenosyl-L-methionine
RHEA:30346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + succinate <=> FADH2 + fumarate
REACT:R-CFA-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Canis familiaris)
REACT:R-SSC-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
RHEA:30859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dITP + H2O = dIDP + H(+) + phosphate
REACT:R-HSA-9007759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSX2 binds RUNX2 gene promoter (Homo sapiens)
REACT:R-RNO-203070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of profilin with monomeric actin (Rattus norvegicus)
RHEA:43378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 5'-deoxyinosine + phosphate
RHEA:50926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2
REACT:R-GGA-9032798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK3 activates RAC1 (Gallus gallus)
RHEA:33875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+)
RHEA:34584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + pentalenolactone D => CO2 + H2O + pentalenolactone E + succinate
REACT:R-GGA-5432825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds TLR4:LY96 (Gallus gallus)
RHEA:53112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH
REACT:R-XTR-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Xenopus tropicalis)
REACT:R-HSA-5334099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UHRF1 binds chromatin with hemimethylated cytosine (Homo sapiens)
RHEA:65398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dAMP + diphosphate + H(+) => 8-oxo-dATP + H2O
RHEA:26305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminophenol + O2 = 2-aminomuconate 6-semialdehyde
RHEA:26305	skos:prefLabel	"2-aminophenol 1,6-dioxygenase"
RHEA:26305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-aminophenol 1,6-dioxygenase"
REACT:R-HSA-9678128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike glycoprotein of SARS coronavirus binds ACE2 on host cell (Homo sapiens)
REACT:R-XTR-5668534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Xenopus tropicalis)
REACT:R-DRE-5357828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8 (Danio rerio)
REACT:R-MMU-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Mus musculus)
RHEA:16589	skos:prefLabel	"glucoside 3-dehydrogenase (acceptor)"
RHEA:16589	skos:altLabel	"D-aldohexopyranoside dehydrogenase"
RHEA:16589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + sucrose = 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2
RHEA:16589	skos:altLabel	"D-glucoside 3-dehydrogenase"
RHEA:16589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucoside 3-dehydrogenase (acceptor)"
REACT:R-CFA-2730862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of LYN kinase (Canis familiaris)
REACT:R-SSC-9026967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 inhibitors binds VKORC1 dimer (Sus scrofa)
REACT:R-SSC-936991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Sus scrofa)
GO:0015144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbohydrate transporter activity
GO:0015144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate transmembrane transporter activity
GO:0015144	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sugar transporter
REACT:R-HSA-164840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP and Pi bind to ATPase (Homo sapiens)
GO:0034838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menthone dehydrogenase activity
RHEA:18093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil
REACT:R-BTA-8948800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNKS and TNKS2 PARylate PTEN (Bos taurus)
REACT:R-MMU-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Mus musculus)
RHEA:22554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+) => 3'-phosphoadenylyl sulfate + an alcohol
REACT:R-DDI-6781814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 deubiquitinates RNF123 (Dictyostelium discoideum)
RHEA:54958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + OPC-6-CoA => ATP + CoA + OPC-6
REACT:R-RNO-201717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK2-mediated phosphorylation of DVL (Rattus norvegicus)
RHEA:14043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mandelonitrile + vicianose => (R)-vicianin + H2O
RHEA:41762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GD3 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E))
RHEA:62775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-phenylalanine <=> N-acetyl-L-phenylalanine
REACT:R-SSC-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Sus scrofa)
RHEA:34185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose
REACT:R-DDI-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Dictyostelium discoideum)
REACT:R-DME-109338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Drosophila melanogaster)
RHEA:12078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + H(+) + NADH => an aromatic primary alcohol + NAD(+)
REACT:R-XTR-193709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)
REACT:R-SCE-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-XTR-2031355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
RHEA:21891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-OPC-8 + NADP(+) <=> (10Z,15Z)-12-oxophytodienoate + H(+) + NADPH
RHEA:46111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 <=> (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)
REACT:R-GGA-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Gallus gallus)
REACT:R-RNO-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Rattus norvegicus)
REACT:R-HSA-3928577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK phosphorylates LIMK1,2 (Homo sapiens)
REACT:R-BTA-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Bos taurus)
REACT:R-SSC-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Sus scrofa)
RHEA:20190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + NAD(+) => H(+) + NADH + uracil
REACT:R-SSC-380272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plk1-mediated phosphorylation of Nlp (Sus scrofa)
REACT:R-BTA-9670673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIX is secreted (Bos taurus)
REACT:R-MMU-202137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 binds eNOS complex via HSP90 (Mus musculus)
GO:0097713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichol-phosphate-mannose synthase regulator activity
GO:0070053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombospondin receptor activity
RHEA:57404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + narcotine hemiacetal = H(+) + NADH + noscapine
RHEA:57404	skos:prefLabel	"noscapine synthase"
RHEA:57404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"noscapine synthase"
RHEA:40955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-phosphomevalonate + ATP = ADP + CO2 + isopentenyl phosphate + phosphate
RHEA:40955	skos:prefLabel	"phosphomevalonate decarboxylase"
RHEA:40955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphomevalonate decarboxylase"
REACT:R-SSC-74718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalisation of the insulin receptor (Sus scrofa)
REACT:R-MMU-389158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
REACT:R-DRE-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Danio rerio)
RHEA:23925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pppGp(2'-5')A => 2',3'-cGAMP + diphosphate
RHEA:29027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + L-glutamate(in) = 2 H(+)(out) + L-glutamate(out)
REACT:R-XTR-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Xenopus tropicalis)
GO:0034900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(N-formyl)-formiminopyruvate hydrolase activity
RHEA:17649	skos:prefLabel	"acetyl-S-ACP:malonate ACP transferase"
RHEA:17649	skos:altLabel	"ACP transferase"
RHEA:17649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + malonate = acetate + malonyl-[ACP]
RHEA:17649	skos:altLabel	"malonate/acetyl-CoA transferase"
RHEA:17649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetyl-S-ACP:malonate ACP transferase"
RHEA:32216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-NADHX => (6S)-NADHX
RHEA:51225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]
RHEA:29522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)
RHEA:21613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate => 2-dehydro-3-deoxy-D-gluconate + H2O
REACT:R-DRE-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Danio rerio)
REACT:R-DME-432527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PP2A dephosphorylates phosphorylated PER (Drosophila melanogaster)
REACT:R-XTR-5607720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p100:RELB binds active NIK:p-IKKA dimer (Xenopus tropicalis)
REACT:R-CEL-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Caenorhabditis elegans)
REACT:R-DDI-69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Dictyostelium discoideum)
RHEA:22706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+) => 2 H2O + ricinine
RHEA:53779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanylpropanoate + O2 <=> 3-sulfinopropanoate + H(+)
RHEA:56589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monosubstituted aliphatic (S)-hydroxynitrile => an aldehyde + hydrogen cyanide
REACT:R-SSC-6814549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA transcript initiation, Integrator binding, LEC binding (Sus scrofa)
RHEA:36113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-methyl gibberellin A1 + S-adenosyl-L-homocysteine => gibberellin A1 + S-adenosyl-L-methionine
REACT:R-HSA-5690991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)
REACT:R-SCE-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Saccharomyces cerevisiae)
RHEA:25850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carvone + H(+) + NADH => (1S,5S)-carveol + NAD(+)
REACT:R-BTA-2002428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen N-propeptides (Bos taurus)
REACT:R-DME-350443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP1-87B:MBS complex dephosphorylates SQH (Drosophila melanogaster)
REACT:R-XTR-352385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Xenopus tropicalis)
RHEA:13886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + stipitatonate => CO2 + stipitatate
REACT:R-DME-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Drosophila melanogaster)
REACT:R-DRE-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Danio rerio)
RHEA:24385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + deamido-NAD(+) + H2O + L-glutamine => AMP + diphosphate + H(+) + L-glutamate + NAD(+)
REACT:R-HSA-190686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of connexins to the Trans-Golgi Network (TGN) (Homo sapiens)
REACT:R-SSC-168848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAK protein (Sus scrofa)
REACT:R-RNO-202960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of C-IAP1 (Rattus norvegicus)
RHEA:44943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)
GO:0047694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	barbiturase activity
GO:0047694	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)
REACT:R-XTR-390281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Xenopus tropicalis)
REACT:R-BTA-9796387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Bos taurus)
RHEA:37313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycyl-L-glutamine(in) + H(+) + phosphate => ATP + glycyl-L-glutamine(out) + H2O
RHEA:71494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)
REACT:R-HSA-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Homo sapiens)
REACT:R-DME-192097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Drosophila melanogaster)
REACT:R-SCE-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)
REACT:R-HSA-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Homo sapiens)
RHEA:10117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP(+) => CO2 + D-ribulose 5-phosphate + NADPH
RHEA:72153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(in) + glutarate(out) => estrone 3-sulfate(out) + glutarate(in)
RHEA:72025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate(out) + urate(in) => nicotinate(in) + urate(out)
GO:0047452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoaphin-aglucone dehydratase (cyclizing) activity
GO:0047452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)
GO:0047452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoaphin dehydratase (cyclizing)
GO:0047452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoaphin dehydratase activity
GO:0047452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoaphin-aglucone hydro-lyase (cyclizing)
REACT:R-SSC-205117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR:NADE promotes caspase2/3 activation (Sus scrofa)
RHEA:44024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O
REACT:R-DME-214398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)
RHEA:21452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidylglycine monooxygenase"
RHEA:21452	skos:altLabel	"PAM"
RHEA:21452	skos:altLabel	"peptidylglycine 2-hydroxylase"
RHEA:21452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical
RHEA:21452	skos:altLabel	"peptidyl alpha-amidating enzyme"
RHEA:21452	skos:prefLabel	"peptidylglycine monooxygenase"
RHEA:21452	skos:altLabel	"peptidylglycine alpha-amidating monooxygenase"
RHEA:16708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + NADP(+) <=> estrone + H(+) + NADPH
REACT:R-DRE-4546386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO1 (Danio rerio)
REACT:R-GGA-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Gallus gallus)
RHEA:63062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+) => 5-methylorsellinate + ATP + H(+) + NADPH
RHEA:53710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)
REACT:R-CEL-9605609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Caenorhabditis elegans)
RHEA:30364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumonisin B1 + 2 H2O => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate
GO:0008574	skos:prefLabel	"plus-end-directed kinesin ATPase"
GO:0008574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plus-end-directed microtubule motor activity
GO:0008574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule motor activity, plus-end-directed
GO:0008574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent microtubule motor activity, plus-end-directed
GO:0008574	skos:altLabel	"kinesin"
GO:0008574	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	kinesin ATP phosphohydrolase (plus-end-directed)
GO:0008574	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plus-end-directed kinesin ATPase activity
GO:0008574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plus-end-directed kinesin ATPase"
GO:0008574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent plus-end-directed microtubule motor activity
GO:0008574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kinesin activity
GO:0008574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plus-end-directed ATP-dependent microtubule motor activity
RHEA:22487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> GMP + GTP + 2 H(+)
RHEA:66198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyltryptamine => acetyl-CoA + tryptamine
REACT:R-DRE-3095889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC dealkylates RCbl (Danio rerio)
REACT:R-SSC-6811454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate PP2A (Sus scrofa)
REACT:R-BTA-877361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyrin binds ASC (Bos taurus)
REACT:R-HSA-9692809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the ER membrane (Homo sapiens)
RHEA:38156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (6E,10E)-geranyllinalool + diphosphate
RHEA:63788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-2213246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of CLIP from MHC II (Homo sapiens)
RHEA:38914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenacoside B + H2O <=> 26-desgluco-avenacoside B + D-glucose
RHEA:24723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 => H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)
RHEA:24057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a myo-inositol phosphate + H2O => myo-inositol + phosphate
RHEA:47978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose
REACT:R-XTR-9707186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 binds ALOX5 inhibitors (Xenopus tropicalis)
RHEA:48704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 12S-HpEPE
RHEA:14964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-formylglutathione <=> formate + glutathione + H(+)
REACT:R-HSA-5632939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the PTEN promoter (Homo sapiens)
RHEA:41376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)
REACT:R-HSA-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)
REACT:R-DRE-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Danio rerio)
REACT:R-HSA-210780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)
RHEA:62905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)
RHEA:17945	skos:altLabel	"(-)-limonene 6-monooxygenase"
RHEA:17945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:17945	skos:altLabel	"(-)-limonene 6-hydroxylase"
RHEA:17945	skos:prefLabel	"(S)-limonene 6-monooxygenase"
RHEA:17945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-limonene 6-monooxygenase"
RHEA:15531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+) => bis(2-ethylhexyl)phthalate + H2O
REACT:R-GGA-8853755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Gallus gallus)
REACT:R-CEL-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Caenorhabditis elegans)
REACT:R-MMU-5693542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RPA complexes with ssDNA at resected DNA DSBs (Mus musculus)
RHEA:64918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O
RHEA:55213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-hydroxyhexadecanoyl-CoA => formyl-CoA + pentadecanal
REACT:R-SPO-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Schizosaccharomyces pombe)
REACT:R-XTR-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Xenopus tropicalis)
RHEA:24816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-valine <=> 3-methyl-2-oxobutanoate + L-glutamate
REACT:R-PFA-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Plasmodium falciparum)
REACT:R-XTR-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Xenopus tropicalis)
REACT:R-XTR-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Xenopus tropicalis)
RHEA:26444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + acetaldehyde => a ubiquinone + ethanol
GO:0140801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H2A-Y142 specific)
GO:0140801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A-Y142 kinase activity
GO:0140801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AY142 kinase activity
RHEA:31401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diapo-zeta-carotene + FADH2 => all-trans-4,4'-diapophytofluene + FAD + H(+)
RHEA:20267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2
REACT:R-DRE-8944218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VIII (Danio rerio)
RHEA:56348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)
RHEA:56348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)
RHEA:56348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoate brominase (decarboxylating)"
RHEA:56348	skos:prefLabel	"4-hydroxybenzoate brominase (decarboxylating)"
REACT:R-BTA-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Bos taurus)
RHEA:61473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + hexadecanoyl-CoA => an N-hexadecanoyl-sphingoid base + CoA + H(+)
GO:0032841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitonin binding
RHEA:32861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol
REACT:R-HSA-8948623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-20 microRNAs bind CNOT6L mRNA (Homo sapiens)
REACT:R-SCE-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Saccharomyces cerevisiae)
REACT:R-RNO-9645501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Rattus norvegicus)
RHEA:70172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + pemetrexed(in) => H(+)(out) + pemetrexed(out)
RHEA:42017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + NAD(+) => 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH
REACT:R-XTR-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Xenopus tropicalis)
REACT:R-XTR-1237081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Xenopus tropicalis)
REACT:R-MMU-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Mus musculus)
REACT:R-SSC-75883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHRS7B reduces GO3P to HXDG3P (Sus scrofa)
RHEA:41484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
RHEA:32860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
RHEA:40185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA + H2O2 => O2 + tetradecanoyl-CoA
REACT:R-SCE-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)
REACT:R-RNO-211951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)
REACT:R-MMU-1964496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds TRIM32 or TRIM56  (Mus musculus)
REACT:R-BTA-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Bos taurus)
RHEA:47980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose
REACT:R-DME-2046180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSPG is secreted from the cell (Drosophila melanogaster)
REACT:R-MMU-9706344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates GRB10 (Mus musculus)
REACT:R-CFA-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Canis familiaris)
RHEA:11163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-2,4-diaminobutanoate <=> L-aspartate 4-semialdehyde + L-glutamate
REACT:R-BTA-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Bos taurus)
REACT:R-XTR-4084989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Xenopus tropicalis)
REACT:R-CFA-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
REACT:R-HSA-4615987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO2,3 (Homo sapiens)
REACT:R-MMU-6804276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TTC5 (Mus musculus)
REACT:R-CFA-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Canis familiaris)
REACT:R-MMU-420131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PACAP receptor binds PACAP (Mus musculus)
REACT:R-MMU-8982641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Mus musculus)
REACT:R-HSA-9617941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of superoxide dismutase 2 (Homo sapiens)
REACT:R-MMU-9033961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Mus musculus)
REACT:R-MMU-2294580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 hyperphosphorylates Condensin II complex (Mus musculus)
REACT:R-HSA-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Homo sapiens)
REACT:R-XTR-6805792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S291-PHF20 translocates to cytosol (Xenopus tropicalis)
RHEA:23305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atropine + H2O => H(+) + tropate + tropine
RHEA:43329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DME-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Drosophila melanogaster)
REACT:R-BTA-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Bos taurus)
REACT:R-HSA-209061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)
REACT:R-RNO-4341048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RXRA with SUMO1 (Rattus norvegicus)
REACT:R-DME-9718360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide agonists (Drosophila melanogaster)
REACT:R-HSA-879798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DEC1 (BHLHE40, BHLHB2) (Homo sapiens)
REACT:R-GGA-2424484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BTK by p-SYK (Gallus gallus)
REACT:R-SSC-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Sus scrofa)
REACT:R-DRE-443402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Danio rerio)
REACT:R-SSC-5653766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)
REACT:R-HSA-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Homo sapiens)
RHEA:57026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate + dihydroxyacetone phosphate => apulose 4-phosphate + D-glyceraldehyde 3-phosphate
RHEA:54703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)
REACT:R-CFA-416546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Canis familiaris)
REACT:R-GGA-353434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Gallus gallus)
REACT:R-HSA-452838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of NANOG (Homo sapiens)
RHEA:60159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-galactose(out) + H2O <=> ADP + D-galactose(in) + H(+) + phosphate
REACT:R-DDI-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)
REACT:R-SSC-2730899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BCL10 and MALT1 (Sus scrofa)
REACT:R-CEL-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Caenorhabditis elegans)
RHEA:63447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized coenzyme F420-0
REACT:R-DME-1614605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is dioxygenated (Drosophila melanogaster)
REACT:R-GGA-2466085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from R* to release atRAL (Gallus gallus)
REACT:R-XTR-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)
REACT:R-HSA-1433514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
RHEA:35657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-AMP + 2 diphosphate => 2 ATP
RHEA:44239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:70959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tyrosine + H2O + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)
REACT:R-DDI-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Dictyostelium discoideum)
REACT:R-HSA-9613219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAD gene expression (Homo sapiens)
RHEA:53494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) => 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in)
REACT:R-MMU-375340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 62 mediated neuronal gap junction communication (Mus musculus)
REACT:R-SCE-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Saccharomyces cerevisiae)
REACT:R-HSA-215526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F3 20-hydroxylates LTB4 (Homo sapiens)
REACT:R-MMU-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Mus musculus)
RHEA:63516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2',3-triol + H(+) + NADH + O2 = biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)
RHEA:27716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + phosphate => GMP + H2O
RHEA:63767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine
REACT:R-MMU-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Mus musculus)
RHEA:67548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
RHEA:71611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + malonate(out) = (S)-malate(out) + malonate(in)
REACT:R-BTA-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Bos taurus)
REACT:R-HSA-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Homo sapiens)
GO:0034779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity
GO:0030228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoprotein particle receptor activity
GO:0030228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoprotein receptor activity
GO:0030228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plasma lipoprotein particle receptor activity
REACT:R-SCE-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Saccharomyces cerevisiae)
REACT:R-SSC-158893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Sus scrofa)
RHEA:10963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate <=> (R)-lactate
GO:0034807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-dihydroxybenzo(a)pyrene methyltransferase activity
REACT:R-DRE-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Danio rerio)
RHEA:46605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[HPr protein]-O-phospho-L-serine + H(+) + phosphate => [HPr protein]-L-serine + diphosphate
REACT:R-GGA-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Gallus gallus)
RHEA:39676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA
RHEA:68385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate
REACT:R-MMU-2213195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of anchoring fibrils (Mus musculus)
GO:0042021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte macrophage colony-stimulating factor complex binding
GO:0042021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF complex binding
GO:0042021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte macrophage colony stimulating factor complex binding
GO:0042021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMC-SF complex binding
REACT:R-BTA-193455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Bos taurus)
REACT:R-CFA-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)
REACT:R-SCE-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)
REACT:R-RNO-372529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of acetylcholine at the synapse (Rattus norvegicus)
REACT:R-HSA-6794353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs binds MUNC18 (Homo sapiens)
REACT:R-DRE-3076905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular BTD hydrolyses BCTN (Danio rerio)
REACT:R-XTR-2396009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds c-di-GMP (Xenopus tropicalis)
RHEA:26485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA + dimethylallyl diphosphate <=> diphosphate + N(6)-dimethylallyladenosine(37) in tRNA
RHEA:58824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:58824	skos:prefLabel	"luteothin monooxygenase"
RHEA:58824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"luteothin monooxygenase"
RHEA:27922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate
REACT:R-BTA-8852167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:Catecholamine binds ARRB1, ARRB2 (Bos taurus)
REACT:R-SSC-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Sus scrofa)
REACT:R-GGA-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Gallus gallus)
RHEA:40366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)
REACT:R-HSA-9634418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 (Homo sapiens)
RHEA:45643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-CFA-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Canis familiaris)
REACT:R-SSC-193073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Sus scrofa)
REACT:R-XTR-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Xenopus tropicalis)
REACT:R-RNO-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Rattus norvegicus)
REACT:R-HSA-264678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Homo sapiens)
REACT:R-HSA-450422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP recruits RNA degradation activities (Homo sapiens)
REACT:R-GGA-8956639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds YAP1 (Gallus gallus)
REACT:R-RNO-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Rattus norvegicus)
REACT:R-MMU-390304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoASH (Mus musculus)
REACT:R-RNO-5607737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 oligomerizes (Rattus norvegicus)
REACT:R-MMU-428749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-proten Gq (Mus musculus)
RHEA:47219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9606784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)
REACT:R-XTR-5226904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Xenopus tropicalis)
REACT:R-DME-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-HSA-5607043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa associates with cell membrane (Homo sapiens)
REACT:R-BTA-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
REACT:R-MMU-9749977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A6 glucuronates ST (Mus musculus)
REACT:R-HSA-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Homo sapiens)
RHEA:52497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0099181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of presynapse
RHEA:12059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + H2O + NAD(+) <=> 4-phospho-D-erythronate + 2 H(+) + NADH
REACT:R-HSA-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Homo sapiens)
REACT:R-RNO-5655466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Rattus norvegicus)
REACT:R-CFA-4332358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)
REACT:R-CFA-77587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Replication Dependent Histone mRNA with the NPC (Canis familiaris)
REACT:R-SSC-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Sus scrofa)
RHEA:64378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2 => 8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid
REACT:R-SSC-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Sus scrofa)
RHEA:47701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ketocytochalasin + NADPH + O2 => H2O + iso-precytochalasin + NADP(+)
RHEA:13456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate
REACT:R-GGA-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Gallus gallus)
RHEA:28850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Li(+)(in) + melibiose(in) <=> Li(+)(out) + melibiose(out)
REACT:R-XTR-9014295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GAPs stimulate RAC2 GTPase activity (Xenopus tropicalis)
RHEA:21215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate
REACT:R-DME-1605632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Both hexosaminidase A and B can cleave GalNAc from globoside (Drosophila melanogaster)
RHEA:20429	skos:prefLabel	"apigenin 4'-O-methyltransferase"
RHEA:20429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin + S-adenosyl-L-methionine = acacetin + H(+) + S-adenosyl-L-homocysteine
RHEA:20429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"apigenin 4'-O-methyltransferase"
RHEA:20429	skos:altLabel	"flavonoid O-methyltransferase"
RHEA:67284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione
REACT:R-RNO-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Rattus norvegicus)
REACT:R-DDI-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Dictyostelium discoideum)
REACT:R-DME-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)
GO:0070041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (uridine-C5-)-methyltransferase activity
REACT:R-HSA-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Homo sapiens)
RHEA:44634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + O2
REACT:R-RNO-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)
RHEA:29698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(I)inamide(in) <=> cob(I)inamide(out)
RHEA:32542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (+)-car-3-ene + diphosphate
REACT:R-DRE-2022399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Danio rerio)
REACT:R-RNO-1299359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TALK (Rattus norvegicus)
REACT:R-SSC-4088134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates FOXM1 (Sus scrofa)
REACT:R-DME-5654646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)
RHEA:18255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADPH + pyruvate => (S)-malate + NADP(+)
RHEA:67085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + hexacosanoate(in) => ADP + H(+) + hexacosanoate(out) + phosphate
RHEA:52383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)
GO:0008715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-diacylglycerol pyrophosphatase activity
GO:0008715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-diacylglycerol diphosphatase activity
GO:0008715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diacylglycerol phosphatidylhydrolase activity
GO:0008715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphodiacylglycerol pyrophosphatase activity
GO:0008715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP diacylglycerol hydrolase activity
REACT:R-RNO-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Rattus norvegicus)
RHEA:20803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-DRE-1250220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of ERBB4 (Danio rerio)
REACT:R-DRE-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Danio rerio)
RHEA:25243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + NH4(+) => (S)-2-ureidoglycine + H2O
REACT:R-SSC-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Sus scrofa)
RHEA:40757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate => (9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate
REACT:R-HSA-4551451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)
REACT:R-BTA-1295540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Bos taurus)
REACT:R-HSA-389964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (Homo sapiens)
RHEA:52782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfenohercynine + NH4(+) + pyruvate => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide
REACT:R-DRE-140769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VII -> factor VIIa (Danio rerio)
RHEA:31311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)
RHEA:28370	skos:altLabel	"PEPCase"
RHEA:28370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoenolpyruvate carboxylase"
RHEA:28370	skos:altLabel	"phosphoenolpyruvic carboxylase"
RHEA:28370	skos:altLabel	"PEP carboxylase"
RHEA:28370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate
RHEA:28370	skos:prefLabel	"phosphoenolpyruvate carboxylase"
GO:0050357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	atropinase activity
GO:0050357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tropinesterase activity
GO:0050357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	atropinesterase activity
GO:0050357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	atropine acylhydrolase activity
GO:0050357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	atropine esterase activity
GO:0050357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tropine esterase activity
RHEA:61880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
REACT:R-HSA-8848335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37 binds  IL18R1 (Homo sapiens)
RHEA:29726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate(in) <=> glyoxylate(out)
REACT:R-DME-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Drosophila melanogaster)
GO:0034829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydec-2,4-diene-1,10-dioate hydratase activity
REACT:R-BTA-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Bos taurus)
REACT:R-RNO-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Rattus norvegicus)
REACT:R-SCE-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Saccharomyces cerevisiae)
GO:0016849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphorus-oxygen lyases"
GO:0016849	skos:prefLabel	"Phosphorus-oxygen lyases"
GO:0016849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorus-oxygen lyase activity
RHEA:60875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP
REACT:R-BTA-5229010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-27 of histone H3 (H3R26) (Bos taurus)
RHEA:47933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + H2O + NAD(+) => (2S)-3-sulfolactate + 2 H(+) + NADH
RHEA:50242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O => [hyaluronan](n)
EC:3.4.13.21	skos:altLabel	"PepE gene product (Salmonella typhimurium)"
EC:3.4.13.21	skos:altLabel	"aspartyl dipeptidase"
EC:3.4.13.21	skos:prefLabel	"dipeptidase E"
EC:3.4.13.21	skos:altLabel	"peptidase E"
EC:3.4.13.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dipeptidase E"
REACT:R-DDI-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Dictyostelium discoideum)
RHEA:28041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dCDP + H2O <=> [thioredoxin]-dithiol + CDP
REACT:R-HSA-4085994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates SIN3A with SUMO1 (Homo sapiens)
REACT:R-CFA-9010872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 binds Dystroglycan (Canis familiaris)
GO:0045518	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-22 receptor ligand
GO:0045518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-22 receptor binding
GO:0045518	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-22
REACT:R-HSA-450474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates BRF1 (Homo sapiens)
REACT:R-XTR-6784861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG binds LPL dimer (Xenopus tropicalis)
RHEA:18707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine
RHEA:36490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine
RHEA:52575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + NAD(+) <=> (2E)-butenoyl-CoA + H(+) + NADH
REACT:R-CEL-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Caenorhabditis elegans)
REACT:R-CFA-174757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Canis familiaris)
RHEA:19710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA
RHEA:10380	skos:altLabel	"orotidylic acid phosphorylase"
RHEA:10380	skos:altLabel	"orotidine-5'-phosphate pyrophosphorylase"
RHEA:10380	skos:altLabel	"OPRT"
RHEA:10380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate
RHEA:10380	skos:prefLabel	"orotate phosphoribosyltransferase"
RHEA:10380	skos:altLabel	"orotidine-5'-phosphate diphosphorylase"
RHEA:10380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"orotate phosphoribosyltransferase"
REACT:R-RNO-5620914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF4:GTP binds VxPx-motifs of membrane proteins (Rattus norvegicus)
RHEA:13187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylbilane + 4 NH4(+) => H2O + 4 porphobilinogen
REACT:R-RNO-174441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Rattus norvegicus)
REACT:R-DDI-1483089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is converted to PS by PTDSS2 (Dictyostelium discoideum)
REACT:R-DDI-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Dictyostelium discoideum)
RHEA:59470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteinylglycine + L-glutamate => an S-substituted glutathione + H2O
REACT:R-RNO-8871265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD4 (Rattus norvegicus)
REACT:R-BTA-8964280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Gq binds BTK (Bos taurus)
REACT:R-XTR-9758674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 oxidizes PREDN,PREDL (Xenopus tropicalis)
REACT:R-BTA-8954398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer hydrolyses cardiolipin to PA and PG (Bos taurus)
RHEA:61692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP = AMP + L-threonyl-[peptidyl-carrier protein]
RHEA:35848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + sphing-4-enine => ADP + H(+) + sphing-4-enine 1-phosphate
REACT:R-BTA-264848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoA-I binds to CUBN:AMN (Bos taurus)
EC:3.8.2.-	skos:prefLabel	"In P-halide compounds"
EC:3.8.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In P-halide compounds"
RHEA:63401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(II)-hydroxyheme i => Fe(II)-heme a + H2O
REACT:R-HSA-8862152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Homo sapiens)
RHEA:59054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine + CO2 => D-lysine + H(+)
RHEA:63660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)
GO:0102702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carene synthase activity
REACT:R-BTA-5661290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Bos taurus)
REACT:R-MMU-9701488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates JAK3 (Mus musculus)
GO:0047446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)
GO:0047446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity
GO:0047446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity
RHEA:47922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)/18:0) + H2O
REACT:R-DME-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Drosophila melanogaster)
REACT:R-RNO-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Rattus norvegicus)
RHEA:12813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate = D-glutamate
RHEA:12813	skos:prefLabel	"glutamate racemase"
RHEA:12813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate racemase"
RHEA:71902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide
REACT:R-MMU-1475032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Mus musculus)
REACT:R-SSC-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Sus scrofa)
REACT:R-RNO-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Rattus norvegicus)
RHEA:39874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-5695989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD11 dehydrogenates BH-CoA (Canis familiaris)
REACT:R-CFA-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Canis familiaris)
REACT:R-DDI-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Dictyostelium discoideum)
REACT:R-CFA-140216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PMAIP1 (NOXA) to mitochondria (Canis familiaris)
RHEA:48495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP
GO:0005459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose transmembrane transporter activity
RHEA:51257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 => (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate
REACT:R-DRE-2327733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 binds Collagen types I-V, VII (Danio rerio)
REACT:R-CEL-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Caenorhabditis elegans)
REACT:R-MMU-266303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds C and E apolipoproteins (Mus musculus)
GO:0030292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine kinase inhibitor activity
REACT:R-CFA-373791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Canis familiaris)
RHEA:67728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA(n) + dZTP = diphosphate + DNA(n)-Z
REACT:R-PFA-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Plasmodium falciparum)
GO:0097016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L27 domain binding
REACT:R-SPO-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Schizosaccharomyces pombe)
REACT:R-SCE-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Saccharomyces cerevisiae)
RHEA:48897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Gallus gallus)
RHEA:41671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + NADP(+) <=> chelirubine + NADPH
REACT:R-DRE-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Danio rerio)
REACT:R-MMU-170810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)
REACT:R-BTA-381612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1 (Bos taurus)
REACT:R-BTA-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Bos taurus)
REACT:R-BTA-1604712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP7 by trypsin (Bos taurus)
REACT:R-HSA-1912406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p53 positively regulates transcription of MIR34 microRNAs (Homo sapiens)
RHEA:24808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate + thiamine diphosphate <=> 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate
REACT:R-RNO-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Rattus norvegicus)
RHEA:60831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-adenosine in mRNA + H2O <=> a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate
REACT:R-XTR-209125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Xenopus tropicalis)
RHEA:16268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate <=> 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-176588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + PAPS => lithocholate sulfate + PAP (Xenopus tropicalis)
REACT:R-DDI-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Dictyostelium discoideum)
RHEA:54132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)
RHEA:61210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein] => 8-nitro-cGMP + L-cysteinyl-[protein]
REACT:R-HSA-71010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUT isomerises L-MM-CoA to SUCC-CoA (Homo sapiens)
RHEA:63742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethanol + NAD(+) => 2-phenylacetaldehyde + H(+) + NADH
RHEA:44422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O
REACT:R-DME-1433506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APS (Drosophila melanogaster)
REACT:R-DRE-6805059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2:FACT phosphorylates TP53 (Danio rerio)
REACT:R-GGA-162730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Gallus gallus)
RHEA:50117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + taurine => CoA + H(+) + N-eicosanoyl-taurine
REACT:R-BTA-2129362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin microfibril assembly (Bos taurus)
REACT:R-DME-3662335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates histone H2A, H2B, H3, H4 (Drosophila melanogaster)
REACT:R-HSA-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Homo sapiens)
REACT:R-SSC-2730902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of p-CARMA1 (Sus scrofa)
RHEA:64428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-proline(out) + H(+)(out) = glycyl-L-proline(in) + H(+)(in)
RHEA:68835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate + H2O <=> (6Z)-nerolidol + diphosphate
RHEA:19487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP => sphing-4-enine + UDP-alpha-D-galactose
RHEA:34955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(methylsulfanyl)-D-ribose(in) = 5-(methylsulfanyl)-D-ribose(out)
REACT:R-DRE-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Danio rerio)
REACT:R-GGA-190261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3c binds to FGF (Gallus gallus)
GO:0031842	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 neuropeptide Y receptor ligand
GO:0031842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 neuropeptide Y receptor binding
REACT:R-XTR-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Xenopus tropicalis)
GO:0098772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular function regulator activity
GO:0098772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular function regulator
REACT:R-DME-428127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Drosophila melanogaster)
RHEA:53688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
RHEA:21222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2
RHEA:47009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite
REACT:R-CFA-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Canis familiaris)
REACT:R-DRE-3371467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates HSF1 (Danio rerio)
RHEA:45444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate
RHEA:46753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-8954398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer hydrolyses cardiolipin to PA and PG (Danio rerio)
REACT:R-MMU-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Mus musculus)
REACT:R-DDI-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Dictyostelium discoideum)
REACT:R-DRE-6799977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 hydrolyzes bacterial peptidoglycan (Danio rerio)
RHEA:29878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-L-serine <=> H(+) + L-serine + sn-glycerol 3-phosphate
RHEA:37354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine 2'-phosphate + H2O <=> cytidine + phosphate
GO:0019111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrol sulfotransferase activity
GO:0019111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrol sulphotransferase activity
RHEA:57884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Na(+)-exporting diphosphatase"
RHEA:57884	skos:altLabel	"Na(+)-translocating membrane pyrophosphatase"
RHEA:57884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate
RHEA:57884	skos:prefLabel	"Na(+)-exporting diphosphatase"
RHEA:57884	skos:altLabel	"sodium-translocating pyrophosphatase"
REACT:R-RNO-382054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binds to extracellular matrix proteins (Rattus norvegicus)
RHEA:22890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA => (R)-methylmalonyl-CoA
REACT:R-BTA-5669240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLNA binds PAK1 (Bos taurus)
RHEA:15174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + NADPH => 2 H2O + NADP(+)
REACT:R-DRE-8938829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Danio rerio)
REACT:R-SSC-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Sus scrofa)
RHEA:72687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol(out) = all-trans-retinol(in)
REACT:R-CEL-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Caenorhabditis elegans)
GO:0090599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-glucosidase activity
RHEA:24602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + sulfate => H2O + O2 + sulfite
REACT:R-DRE-8987179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Danio rerio)
REACT:R-DRE-8956184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Danio rerio)
RHEA:36013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA
REACT:R-BTA-176669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Bos taurus)
REACT:R-CEL-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Caenorhabditis elegans)
RHEA:56640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-HSA-69756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes (Homo sapiens)
GO:0106153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated histone binding
REACT:R-MMU-199154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD200 binds to CD200R (Mus musculus)
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHPDH
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydropyrimidine dehydrogenase activity
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPD
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrouracil dehydrogenase (NADP+) activity
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrothymine dehydrogenase activity
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6-dihydrouracil:NADP+ 5-oxidoreductase activity
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydropyrimidine dehydrogenase (NADP+) activity
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,5-dihydrothymine: oxidoreductase activity
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydropyrimidine dehydrogenase activity
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHU dehydrogenase activity
GO:0017113	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrouracil dehydrogenase (NADP)
RHEA:57380	skos:altLabel	"CYP82X2"
RHEA:57380	skos:prefLabel	"(S)-1-hydroxy-N-methylcanadine 13-hydroxylase"
RHEA:57380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-1-hydroxy-N-methylcanadine 13-hydroxylase"
RHEA:57380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate + H(+) => CO2 + L-erythrulose
GO:0015124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate transmembrane transporter activity
RHEA:34825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 CoA + curcumin => (E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O
REACT:R-HSA-444572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zinc is an agonist of GPR39 (Homo sapiens)
RHEA:31200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O
REACT:R-XTR-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Xenopus tropicalis)
REACT:R-HSA-5655336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 mutants (Homo sapiens)
RHEA:33664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine
REACT:R-CEL-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Caenorhabditis elegans)
GO:0052578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-farnesene synthase activity
GO:0052578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-alpha-farnesene synthase activity
RHEA:24772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + NADP(+) = chlorophyllide b + H(+) + NADPH
REACT:R-DRE-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Danio rerio)
REACT:R-MMU-390281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Mus musculus)
GO:0102025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type thiosulfate transporter activity
GO:0102025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulphate ABC transporter activity
GO:0102025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled thiosulfate transmembrane transporter activity
GO:0102025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate transmembrane-transporting ATPase activity
RHEA:57826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate + adenine => dAMP + H2O
RHEA:31952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:44685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine
REACT:R-RNO-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Rattus norvegicus)
RHEA:26364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + NADPH + S-adenosyl-L-methionine <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)
REACT:R-XTR-204824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Ang4 (Xenopus tropicalis)
REACT:R-GGA-5622134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRABP1 binds atRA (Gallus gallus)
REACT:R-BTA-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)
RHEA:31420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => (-)-beta-curcumene + diphosphate
RHEA:28836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + succinate(in) => citrate(in) + succinate(out)
RHEA:55254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:49626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-erythritol 1-phosphate + H(+) => ATP + erythritol
RHEA:32560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => diphosphate + gamma-terpinene
REACT:R-DDI-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Dictyostelium discoideum)
REACT:R-CFA-374664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of Ezrin (Canis familiaris)
REACT:R-GGA-2132276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I inactivates C3b (Gallus gallus)
REACT:R-BTA-2130641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TGN-lysosome vesicle to lysosome (Bos taurus)
RHEA:36060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydrourocanate => AH2 + urocanate
REACT:R-XTR-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Xenopus tropicalis)
RHEA:51376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-dopamine
GO:0008613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diuretic hormone activity
REACT:R-HSA-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Homo sapiens)
REACT:R-DME-9604328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates NOTCH4 (Drosophila melanogaster)
RHEA:60143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetradecanoyl-CoA + CO2 + CoA
REACT:R-PFA-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Plasmodium falciparum)
RHEA:71248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(out) + chloride(out) + 2 Na(+)(out) => beta-alanine(in) + chloride(in) + 2 Na(+)(in)
REACT:R-CEL-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Caenorhabditis elegans)
RHEA:60262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine
REACT:R-DDI-5690157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP16,USP21 deubiquitinate Histone H2A (Dictyostelium discoideum)
REACT:R-MMU-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Mus musculus)
REACT:R-SSC-2161959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Sus scrofa)
RHEA:38348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate
RHEA:43469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 => (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate
REACT:R-HSA-5251559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deletions of the AMER1 gene prevent expression of AMER1 protein (Homo sapiens)
REACT:R-DRE-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Danio rerio)
REACT:R-CEL-3341397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)
REACT:R-SSC-2018682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Sus scrofa)
RHEA:60214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2
RHEA:58689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + O2 + rifamycin SV => H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide
RHEA:57465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + UDP-alpha-D-glucose => 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP
REACT:R-HSA-6800816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 or TP63 stimulates PERP gene expression (Homo sapiens)
RHEA:37811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-5689972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
GO:0022890	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	monovalent inorganic cation transmembrane transporter activity
GO:0022890	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	divalent inorganic cation transmembrane transporter activity
GO:0022890	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	di-, tri-valent inorganic cation transmembrane transporter activity
GO:0022890	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	trivalent inorganic cation transmembrane transporter activity
GO:0022890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic cation transmembrane transporter activity
REACT:R-DME-5579023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA2(869-1464) binds KAT6A(1-1118) (Drosophila melanogaster)
RHEA:22867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine <=> D-lysine
RHEA:35210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IDP <=> H(+) + IMP + phosphate
REACT:R-BTA-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Bos taurus)
GO:0047142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity
GO:0047142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme-thiol transhydrogenase (glutathione-disulfide) activity
GO:0047142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione-dependent thiol:disulfide oxidoreductase activity
GO:0047142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiol:disulfide oxidoreductase activity
GO:0047142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity
GO:0047142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme-thiol transhydrogenase (glutathione-disulphide) activity
GO:0047142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme-thiol transhydrogenase (oxidized-glutathione) activity
GO:0047142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity
GO:0047142	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiol:disulphide oxidoreductase activity
REACT:R-DME-210700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEN dimer represses transcription (Drosophila melanogaster)
GO:0034562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity
REACT:R-HSA-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)
REACT:R-DRE-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Danio rerio)
REACT:R-BTA-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Bos taurus)
RHEA:59354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + lactobiono-1,5-lactone => beta-lactose + O2
RHEA:70718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) <=> glycine(out)
REACT:R-BTA-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Bos taurus)
REACT:R-RNO-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Rattus norvegicus)
RHEA:31007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-amyrin synthase"
RHEA:31007	skos:prefLabel	"beta-amyrin synthase"
RHEA:31007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = beta-amyrin
RHEA:31007	skos:altLabel	"2,3-oxidosqualene beta-amyrin cyclase"
RHEA:27559	skos:prefLabel	"hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]"
RHEA:27559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 3 diphosphate
RHEA:27559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]"
RHEA:27559	skos:altLabel	"HexPS"
RHEA:27559	skos:altLabel	"hexaprenyl diphosphate synthase"
RHEA:27559	skos:altLabel	"hexaprenyl pyrophosphate synthetase"
RHEA:53034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate
REACT:R-HSA-163432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol ester + H2O -> cholesterol + fatty acid (Homo sapiens)
REACT:R-GGA-976991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor ligands bind the prolactin receptor (Gallus gallus)
REACT:R-CEL-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Caenorhabditis elegans)
RHEA:40752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate
REACT:R-XTR-389424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The orphan QRFP receptor can bind neuropeptide QRFP (Xenopus tropicalis)
RHEA:67622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine
GO:0047367	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity
GO:0047367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin-3,3'-bissulphate 7-sulphotransferase activity
GO:0047367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin-3,3'-bissulfate 7-sulfotransferase activity
GO:0047367	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity
GO:0047367	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-sulfotransferase activity
GO:0047367	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 7-sulfotransferase activity
REACT:R-HSA-1678694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Homo sapiens)
REACT:R-GGA-9021523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWP2 ubiquitinates NOTCH3 (Gallus gallus)
GO:0015199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino-acid betaine transmembrane transporter activity
GO:0015199	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycine betaine/proline porter activity
GO:0015199	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	betaine/GABA:sodium symporter activity
GO:0015199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine transmembrane transporter activity
GO:0015199	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proline/glycine/betaine:hydrogen/sodium symporter activity
GO:0034577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-isopropylacetaniline monooxygenase activity
REACT:R-CFA-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Canis familiaris)
REACT:R-XTR-9008054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RAPL1 (Xenopus tropicalis)
REACT:R-MMU-9013109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GEFs activate RHOC (Mus musculus)
REACT:R-CEL-1602454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proMMP9 binds TIMP1 (Caenorhabditis elegans)
REACT:R-HSA-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
REACT:R-CEL-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Caenorhabditis elegans)
RHEA:59236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + isoelisabethatriene
RHEA:59236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoelisabethatriene synthase"
RHEA:59236	skos:prefLabel	"isoelisabethatriene synthase"
REACT:R-MMU-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Mus musculus)
REACT:R-DRE-5693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYM reduces P2C to PPCA (Danio rerio)
RHEA:66504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-446894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binding leads to IRAK1:TRAF6 release (Danio rerio)
REACT:R-HSA-391936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP1 receptor can bind PGE2 (Homo sapiens)
REACT:R-DME-1470009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs (Drosophila melanogaster)
RHEA:22834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formyl-L-glutamate + NH4(+) => H2O + N-formimidoyl-L-glutamate
RHEA:70251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine
REACT:R-HSA-9717193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB1,3:GNG13 binds PLCB2:Ca2+ (Homo sapiens)
REACT:R-MMU-9025152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Mus musculus)
RHEA:22006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[myosin light chain] => ATP + L-seryl-[myosin light chain]
RHEA:22037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + D-glucose => [phosphate](n-1) + D-glucose 6-phosphate + H(+)
REACT:R-HSA-8864936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA gene expression is inhibited by the TFAP2A homodimer (Homo sapiens)
REACT:R-DME-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Drosophila melanogaster)
REACT:R-BTA-9008577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37:IL18R1 binds SIGIRR (Bos taurus)
RHEA:39558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)
REACT:R-DRE-377644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of CSK from SRC (Danio rerio)
RHEA:13277	skos:altLabel	"cyanophycin synthetase"
RHEA:13277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanophycin synthase (L-aspartate-adding)"
RHEA:13277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate
RHEA:13277	skos:prefLabel	"cyanophycin synthase (L-aspartate-adding)"
RHEA:13277	skos:altLabel	"multi-L-arginyl-poly-L-aspartate synthase"
REACT:R-DRE-981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3 convertases spontaneously dissociate (Danio rerio)
RHEA:28007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(alpha)-methyl-L-tryptophan + O2 => formaldehyde + H2O2 + L-tryptophan
REACT:R-MMU-8854071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome-mediated degradation of PolyUb-FBXL7 (Mus musculus)
GO:0033915	skos:prefLabel	"mannan 1,2-(1,3)-alpha-mannosidase"
GO:0033915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannan 1,2-(1,3)-alpha-mannosidase activity
GO:0033915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-1,3-alpha-D-mannan mannohydrolase activity
GO:0033915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannan 1,2-(1,3)-alpha-mannosidase"
GO:0033915	skos:altLabel	"exo-1,2-1,3-alpha-mannosidase"
GO:0033915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,2-1,3-alpha-mannosidase activity
RHEA:51571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Danio rerio)
REACT:R-SSC-110376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Sus scrofa)
RHEA:40842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + nonanoyl-CoA <=> (2E)-nonenoyl-CoA + FADH2
RHEA:36958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA <=> (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-199144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin 2 binds CD226 (Homo sapiens)
REACT:R-DDI-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Dictyostelium discoideum)
GO:1901604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dethiobiotin transmembrane transporter activity
RHEA:50938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + L-glutamate => (3S)-3-aminobutanoyl-CoA + 2-oxoglutarate
REACT:R-SSC-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)
RHEA:51358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-glutamine => H2O + N-(9Z-octadecenoyl)-L-glutamine
REACT:R-MMU-2162225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from small HA fragments (Mus musculus)
REACT:R-SCE-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Saccharomyces cerevisiae)
REACT:R-DME-9023840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HATs and coactivators are recruited to the CTSD gene (Drosophila melanogaster)
RHEA:29202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + menaquinone-8 <=> menaquinol-8 + orotate
RHEA:43194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine
REACT:R-DDI-446200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLPP1 dephosphorylates DOLDP to DOLP (Dictyostelium discoideum)
REACT:R-CEL-443779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Linkage of L1 with treadmilling F-actin (Caenorhabditis elegans)
REACT:R-SSC-1247922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCT transforms gGluCys to OPRO (Sus scrofa)
RHEA:65979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + hnu <=> previtamin D3
RHEA:32255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)
REACT:R-SSC-6803719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds ZNF385A (Sus scrofa)
REACT:R-BTA-5218838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXN binds p-6Y,S732-PTK2 (Bos taurus)
RHEA:47920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)/18:0) + H2O = ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate
REACT:R-GGA-8851890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates SHC1-2 (Gallus gallus)
REACT:R-DRE-5218905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Danio rerio)
REACT:R-RNO-204850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Dok-2 (Rattus norvegicus)
REACT:R-HSA-1169406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host proteins (Homo sapiens)
REACT:R-CEL-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Caenorhabditis elegans)
RHEA:55712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)
REACT:R-MMU-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Mus musculus)
RHEA:55413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + GTP => [phosphate](n+1) + GDP
REACT:R-BTA-8876837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB21 GEFs exchange GTP for GDP on RAB21 (Bos taurus)
REACT:R-MMU-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Mus musculus)
REACT:R-PFA-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-XTR-5691150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFR2 dimer binds 2xholoTF (Xenopus tropicalis)
REACT:R-DDI-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Dictyostelium discoideum)
RHEA:64284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + pyruvate = 2-phenylacetaldehyde + L-alanine
REACT:R-GGA-549322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations out of hepatic cells (Gallus gallus)
REACT:R-MMU-5683077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate KDM4A,B (Mus musculus)
RHEA:25956	skos:prefLabel	"3-dehydroquinate synthase II"
RHEA:25956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydroquinate synthase II"
RHEA:25956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)
RHEA:25956	skos:altLabel	"DHQ synthase II"
REACT:R-CFA-1676149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)
RHEA:25837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => 5-deoxy-D-glucuronate + H(+)
REACT:R-BTA-193995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 18-hydroxylates CORST to 18HCORST (Bos taurus)
RHEA:53868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + phenazine-1-carboxylate = 1-hydroxyphenazine + CO2 + H2O + NAD(+)
RHEA:21895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose + NADP(+) <=> D-arabinono-1,4-lactone + H(+) + NADPH
REACT:R-DME-77340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Drosophila melanogaster)
REACT:R-DME-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Drosophila melanogaster)
GO:0090482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin transmembrane transporter activity
GO:0090482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin transporter activity
GO:0090482	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	vitamin or cofactor transporter activity
REACT:R-DDI-77585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Dictyostelium discoideum)
REACT:R-XTR-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Xenopus tropicalis)
REACT:R-XTR-165777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4B by activated S6K1 (Xenopus tropicalis)
REACT:R-MMU-4332236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL neddylates TGFBR2 (Mus musculus)
GO:0102905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valencene synthase activity
RHEA:68814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate
REACT:R-RNO-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Rattus norvegicus)
REACT:R-MMU-9014294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the plasma membrane (Mus musculus)
REACT:R-CEL-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Caenorhabditis elegans)
REACT:R-GGA-1462023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-pro-defensins are cleaved to remove the signal peptide (Gallus gallus)
REACT:R-HSA-2161187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Homo sapiens)
GO:0043430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity
GO:0043430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
REACT:R-SSC-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Sus scrofa)
REACT:R-DME-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)
REACT:R-XTR-109813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1 binds SOS1 (Xenopus tropicalis)
REACT:R-CEL-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Caenorhabditis elegans)
REACT:R-DRE-373717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacts with DIP13alpha (Danio rerio)
REACT:R-DRE-8875661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA3 associates with activated MET receptor (Danio rerio)
RHEA:70012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzoyl-AMP + CoA => AMP + anthraniloyl-CoA + H(+)
REACT:R-DME-8940074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NMN (Drosophila melanogaster)
REACT:R-MMU-6805126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates TP53 (Mus musculus)
REACT:R-BTA-6793685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated TP53 translocates to the cytosol (Bos taurus)
REACT:R-DRE-5626316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Danio rerio)
RHEA:29950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-rhamnopyranose(in) <=> H(+)(out) + L-rhamnopyranose(out)
REACT:R-GGA-9668831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CST complex formation (Gallus gallus)
REACT:R-BTA-429767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Bos taurus)
REACT:R-BTA-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Bos taurus)
REACT:R-MMU-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Mus musculus)
REACT:R-GGA-8941543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Gallus gallus)
REACT:R-HSA-422088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Preproghrelin (Homo sapiens)
RHEA:72062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate(out) + 2 Na(+)(out) <=> glycochenodeoxycholate(in) + 2 Na(+)(in)
REACT:R-XTR-3214912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate MeK5-histone H3 (Xenopus tropicalis)
RHEA:54829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + H(+) + NADPH + O2 => formaldehyde + H2O + methylamine + NADP(+)
RHEA:61669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + salicylate => 2-hydroxybenzoyl-CoA + AMP + diphosphate
REACT:R-SSC-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Sus scrofa)
REACT:R-SSC-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Sus scrofa)
RHEA:29666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + xanthine(in) <=> H(+)(out) + xanthine(out)
REACT:R-CFA-381543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP4 binds IGF forming IGF:IGFBP4 (Canis familiaris)
RHEA:11785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate + NADP(+) => H(+) + NADPH + NH4(+) + oxaloacetate
RHEA:21831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-5218839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)
RHEA:45590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-[ACP] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[ACP]
REACT:R-HSA-8939082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the CR1 gene promoter (Homo sapiens)
RHEA:28664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + melibiose => D-galactose + D-glucose
RHEA:68575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine(in) <=> L-tyrosine(out)
REACT:R-HSA-6801415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates NLRC4 expression (Homo sapiens)
REACT:R-CFA-5651773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds POLB at long-patch BER site (Canis familiaris)
REACT:R-MMU-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Mus musculus)
REACT:R-SSC-176879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein(a) + LDL => Lp(a) (Sus scrofa)
RHEA:45080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine = ADP + dapdiamide E + H(+) + phosphate
RHEA:23034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP
REACT:R-DDI-193535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)
REACT:R-SPO-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Schizosaccharomyces pombe)
REACT:R-DRE-2161950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Danio rerio)
REACT:R-MMU-1912372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fringe-modified Pre-NOTCH is cleaved by FURIN (Mus musculus)
GO:0033703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity
GO:0033703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity
GO:0033703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3beta-hydroxysteroid 5beta-oxidoreductase activity
GO:0033703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5beta-steroid dehydrogenase activity
REACT:R-HSA-157629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2-ligand complex is cleaved to produce NEXT2 (Homo sapiens)
RHEA:72303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + L-thyroxine(out) = L-glutamate(out) + L-thyroxine(in)
RHEA:16824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NAD(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADH
RHEA:42776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:42776	skos:prefLabel	"16S rRNA (adenine(1408)-N(1))-methyltransferase"
RHEA:42776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (adenine(1408)-N(1))-methyltransferase"
RHEA:62142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + GDP => dTMP + GTP
RHEA:63554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin-(1-5) + L-histidyl-L-proline => angiotensin-(1-7) + H2O
RHEA:57958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfone + H2O + NAD(+) => dimethyl sulfoxide + H(+) + NADH + O2
RHEA:15807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate => (7R,8S)-7,8-diammoniononanoate + ATP + CO2
REACT:R-PFA-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Plasmodium falciparum)
RHEA:39393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH
REACT:R-CEL-109449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)
REACT:R-MMU-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)
REACT:R-BTA-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Bos taurus)
REACT:R-DME-112436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin complex (Drosophila melanogaster)
REACT:R-GGA-981809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Gallus gallus)
RHEA:59270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + formaldehyde + L-lysyl-[protein] => A + H2O + N(6)-methyl-L-lysyl-[protein]
REACT:R-RNO-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)
REACT:R-SSC-9014433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GEFs activate RHOG (Sus scrofa)
RHEA:44689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + H2O => a fatty acid + glycerol + H(+)
REACT:R-CFA-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Canis familiaris)
REACT:R-HSA-6793661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)
REACT:R-SSC-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Sus scrofa)
REACT:R-MMU-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Mus musculus)
GO:0016823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
GO:0016823	skos:prefLabel	"In ketonic substances"
GO:0016823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In ketonic substances"
RHEA:70147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-2022405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)
REACT:R-SSC-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Sus scrofa)
REACT:R-SSC-6797568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind CASK:Protein 4.1 (Sus scrofa)
REACT:R-DRE-2396007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3 is phosphorylated by TBK1 (Danio rerio)
REACT:R-MMU-6809810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Mus musculus)
RHEA:46448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclo(L-tyrosyl-L-tyrosyl) synthase"
RHEA:46448	skos:prefLabel	"cyclo(L-tyrosyl-L-tyrosyl) synthase"
RHEA:46448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-tyrosyl-tRNA(Tyr) = cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)
RHEA:46448	skos:altLabel	"cyclodityrosine synthase"
REACT:R-HSA-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Homo sapiens)
GO:0031433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telethonin binding
REACT:R-HSA-9761849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2-dependent P6GD gene expression (Homo sapiens)
REACT:R-HSA-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Homo sapiens)
REACT:R-BTA-3296309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR3 binds HCAR3 ligands (Bos taurus)
RHEA:33082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-6-deoxyfutalosine + H2O <=> adenine + dehypoxanthine futalosine
REACT:R-DDI-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Dictyostelium discoideum)
RHEA:72854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + AMP(in) <=> ADP(in) + AMP(out)
REACT:R-MMU-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Mus musculus)
REACT:R-RNO-354066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PTK2 to Focal complexes (Rattus norvegicus)
REACT:R-MMU-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Mus musculus)
RHEA:18445	skos:altLabel	"inosinicase"
RHEA:18445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
RHEA:18445	skos:prefLabel	"IMP cyclohydrolase"
RHEA:18445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"IMP cyclohydrolase"
RHEA:18445	skos:altLabel	"IMP synthetase"
RHEA:10829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + ATP + CoA => AMP + anthraniloyl-CoA + diphosphate
RHEA:60254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acryloyl-CoA + CO2 + NADPH => (S)-methylmalonyl-CoA + NADP(+)
REACT:R-MMU-9726875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCNs:cAMP bind SNIs (Mus musculus)
RHEA:20734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + [thioredoxin]-dithiol => [protein]-dithiol + [thioredoxin]-disulfide
RHEA:45929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:44773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)
RHEA:72832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP + H2O => G[3'-5']pAp[3'] + H(+)
RHEA:56340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-167118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex (Homo sapiens)
REACT:R-CFA-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Canis familiaris)
RHEA:44638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitrophenol + H(+) + methanol => 2,4-dinitroanisole + H2O
RHEA:62895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + 2 H2O + nor-toralactone
REACT:R-SSC-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Sus scrofa)
REACT:R-BTA-8849082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 stimulates RHOA GTPase activity (Bos taurus)
REACT:R-DME-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Drosophila melanogaster)
REACT:R-SSC-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Sus scrofa)
RHEA:45921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:67306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + myceliothermophin E => 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2
REACT:R-XTR-1889955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT dimers transfer GlcA to tetrasaccharide linker (Xenopus tropicalis)
REACT:R-CEL-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Caenorhabditis elegans)
REACT:R-HSA-549470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CRYPTOCHROME-2 (Homo sapiens)
RHEA:71582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP(out) + CDP-L-ribitol(in) <=> CDP(in) + CDP-L-ribitol(out)
GO:0018491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ketobutyrate synthase activity
GO:0018491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutyrate synthase activity
GO:0018491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketobutyrate synthase activity
GO:0018491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutyrate-ferredoxin oxidoreductase activity
GO:0018491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketobutyrate-ferredoxin oxidoreductase activity
GO:0018491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)
RHEA:22770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one => 4-nitrophenyl-3-ketovalidamine
REACT:R-RNO-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Rattus norvegicus)
RHEA:70231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) = (S)-2-benzoylsuccinyl-CoA + H(+) + NADH
RHEA:13718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 4-phosphate + NADP(+) => 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase A activity
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pancreatic RNase activity
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceratitis capitata alkaline ribonuclease activity
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoribonuclease I
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkaline ribonuclease activity
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNase activity
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SLSG glycoproteins
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gene S glycoproteins
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-genotype-assocd. glycoproteins
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gene S locus-specific glycoproteins
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease I activity
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease A activity
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase I activity
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleic phosphatase activity
GO:0004522	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pancreatic ribonuclease activity
REACT:R-SSC-9018880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Sus scrofa)
REACT:R-RNO-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Rattus norvegicus)
REACT:R-DDI-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Dictyostelium discoideum)
REACT:R-XTR-9667456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B bind desmopressin (Xenopus tropicalis)
RHEA:61950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2
RHEA:15839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-L-glutamate + NH4(+) => L-glutamate + methylamine
REACT:R-CFA-5694421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6 dephosphorylates SEC24 (Canis familiaris)
REACT:R-GGA-372852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Gallus gallus)
REACT:R-BTA-5362459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)
REACT:R-SPO-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Schizosaccharomyces pombe)
RHEA:71336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-tryptophan(out) + 2 Na(+)(out) => chloride(in) + L-tryptophan(in) + 2 Na(+)(in)
RHEA:25534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ent-cassa-12,15-diene => ent-copalyl diphosphate
GO:0043890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose-6-sulfate sulfatase activity
GO:0043890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylgalactosamine 6-sulfatase activity
GO:0043890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine 6-sulfatase activity
GO:0043890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine-6-sulfatase activity
GO:0043890	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinsulfatase
GO:0043890	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitin sulfatase
GO:0043890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity
GO:0043890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine-6-sulfate sulfatase activity
GO:0043890	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinase
REACT:R-HSA-8950623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Carbonic anhydrase 1 (Homo sapiens)
REACT:R-HSA-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Homo sapiens)
REACT:R-RNO-917814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Rattus norvegicus)
REACT:R-CEL-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Caenorhabditis elegans)
REACT:R-SSC-2160892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Sus scrofa)
REACT:R-XTR-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Xenopus tropicalis)
RHEA:39434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-HSA-200954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nef Binds and activates the Src-family tyrosine kinase Lck (Homo sapiens)
REACT:R-SSC-9726949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIR binds PTGIR agonists (Sus scrofa)
RHEA:28113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + S-adenosyl-L-methionine <=> 5'-chloro-5'-deoxyadenosine + L-methionine
RHEA:35185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxy-2-thioxobutanoyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + H2O
RHEA:42721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2552) in 23S rRNA => 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-2032770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1 to the nucleus (Mus musculus)
RHEA:56707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate
RHEA:25147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde = H(+) + H2O + quinolinate
REACT:R-DRE-429694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 dissociates from the endoplasmic reticulum (Danio rerio)
REACT:R-DDI-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Dictyostelium discoideum)
RHEA:64991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H2O <=> (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
RHEA:27788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADH + succinyl-CoA => 2-oxoglutarate + CoA + NAD(+)
REACT:R-HSA-8932021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and ESR1 bind the GPAM gene enhancer (Homo sapiens)
REACT:R-CFA-433698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
REACT:R-RNO-77327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Rattus norvegicus)
REACT:R-SSC-8939801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades PolyUb-RUNX2 (Sus scrofa)
RHEA:65086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:67303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one <=> 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one
REACT:R-BTA-213406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from LAT (Bos taurus)
REACT:R-SCE-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Saccharomyces cerevisiae)
RHEA:61758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + rebaudioside A + UDP => stevioside + UDP-alpha-D-glucose
REACT:R-HSA-8950448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)
RHEA:21751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + NADP(+) <=> H(+) + methylglyoxal + NADPH
GO:0102291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11alpha-hydroxy-beta-amyrin dehydrogenase activity
REACT:R-GGA-167419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex releases GDP (Gallus gallus)
RHEA:71284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-glutamine(out) + 2 Na(+)(out) => chloride(in) + L-glutamine(in) + 2 Na(+)(in)
REACT:R-RNO-9716258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimethyl fumarate modifies Cys191 in GSDMD (Rattus norvegicus)
REACT:R-HSA-9727607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ binds sacubitrilat (Homo sapiens)
REACT:R-XTR-158251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Xenopus tropicalis)
RHEA:48395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
GO:0043766	skos:altLabel	"Sep-tRNA:Cys-tRNA synthase"
GO:0043766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate
GO:0043766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity
GO:0043766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sep-tRNA:Cys-tRNA synthase activity
GO:0043766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-phospho-L-seryl-tRNA:Cys-tRNA synthase"
GO:0043766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SepCysS
GO:0043766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sep-tRNA:Cys-tRNA synthetase activity
GO:0043766	skos:altLabel	"SepCysS"
GO:0043766	skos:prefLabel	"O-phospho-L-seryl-tRNA:Cys-tRNA synthase"
REACT:R-DDI-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Dictyostelium discoideum)
REACT:R-HSA-5655270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2 (Homo sapiens)
RHEA:24359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine
REACT:R-SSC-8950780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 binds p-Y693-STAT4 (Sus scrofa)
RHEA:63996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)
REACT:R-DME-432897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ILK interacts with beta-1 integrin (Drosophila melanogaster)
REACT:R-BTA-379464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DOPAC to form HVA (Bos taurus)
REACT:R-GGA-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Gallus gallus)
GO:0016828	skos:prefLabel	"Acting on sulfur-sulfur bonds"
GO:0016828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid sulfur-sulfur bonds
GO:0016828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on sulfur-sulfur bonds"
GO:0016828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid sulphur-sulphur bonds
RHEA:67414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-DME-5658438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRED dimer binds NF1 (Drosophila melanogaster)
RHEA:48433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-D-ribulosyl-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]
GO:0051778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-7-alpha-hydroxykaurenoate oxidase activity
REACT:R-CEL-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Caenorhabditis elegans)
RHEA:67942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxooctanoate + H2O2 => 2-hydroxyoctanoate + O2
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steryl-ester acylhydrolase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol ester hydrolase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cholesterol esterase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol esterase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cholesterol ester synthase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesteryl esterase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesteryl ester hydrolase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylcholesterol lipase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triterpenol esterase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol ester hydrolase activity
GO:0004771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesteryl ester synthase activity
RHEA:66207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptanoyl-CoA + O2 <=> (2E)-heptenoyl-CoA + H2O2
RHEA:34557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H(+) + NADH => a (2S)-2-hydroxycarboxylate + NAD(+)
REACT:R-HSA-2534206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by PS1:NCSTN (Gamma-secretase) (Homo sapiens)
RHEA:24850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + H2O => 3-dehydroshikimate
GO:0033828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosylglycerol-phosphate synthase activity
GO:0033828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosyl-glycerol-phosphate synthase activity
GO:0033828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GG-phosphate synthase activity
GO:0033828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity
GO:0033828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity
GO:0033828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GGPS
REACT:R-SSC-5577213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Sus scrofa)
RHEA:40848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + FAD + H(+) => (2E)-eicosenoyl-CoA + FADH2
RHEA:32191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Bos taurus)
REACT:R-GGA-8875482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin to ubiquitinated MET (Gallus gallus)
REACT:R-HSA-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Homo sapiens)
EC:3.2.1.176	skos:altLabel	"cellulase SS"
EC:3.2.1.176	skos:prefLabel	"cellulose 1,4-beta-cellobiosidase (reducing end)"
EC:3.2.1.176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellulose 1,4-beta-cellobiosidase (reducing end)"
EC:3.2.1.176	skos:altLabel	"endoglucanase SS"
RHEA:31040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + FAD + H(+) => (2E)-dodecenoyl-CoA + FADH2
REACT:R-GGA-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Gallus gallus)
REACT:R-MMU-202489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of Bcl10 (Mus musculus)
REACT:R-DME-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Drosophila melanogaster)
REACT:R-CEL-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Caenorhabditis elegans)
REACT:R-CEL-5617828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIP11:IFT20 dissociates (Caenorhabditis elegans)
RHEA:65063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH
REACT:R-DME-432510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLK is degraded by the 26S proteasome (Drosophila melanogaster)
REACT:R-RNO-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)
RHEA:67909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary linear alkyl sulfate ester + H2O => a primary alcohol + H(+) + sulfate
RHEA:15999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+) => anthraniloyl-CoA + 2 H(+) + 2 NADH + O2
REACT:R-SSC-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Sus scrofa)
REACT:R-HSA-199161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fc gamma receptors interact with antigen-bound IgG (Homo sapiens)
RHEA:43131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine
RHEA:57654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GM1alpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1
REACT:R-SSC-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Sus scrofa)
REACT:R-BTA-937034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino (Bos taurus)
REACT:R-HSA-1566979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminin-332 degradation by laminin-322 degrading extracellular proteinases (Homo sapiens)
RHEA:42939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(32) in tRNA <=> 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-9693978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Small molecule inhibitor binds RIPK1, RIPK3 (Sus scrofa)
REACT:R-BTA-179467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Bos taurus)
REACT:R-XTR-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Xenopus tropicalis)
REACT:R-XTR-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Xenopus tropicalis)
REACT:R-RNO-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Rattus norvegicus)
RHEA:69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP => 3',5'-cyclic UMP + diphosphate
REACT:R-DDI-9647977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT methylates S-Farn RAS proteins (Dictyostelium discoideum)
REACT:R-RNO-1475022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (cytosol) (Rattus norvegicus)
REACT:R-DRE-8983300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Danio rerio)
GO:0033445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGU codon-amino acid adaptor activity
GO:0033445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine tRNA
GO:0033445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT codon-amino acid adaptor activity
GO:0034540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-monobromobisphenol A reductive dehalogenase activity
GO:0102249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine:diacylglycerol cholinephosphotransferase activity
REACT:R-HSA-174456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)
REACT:R-SSC-8851859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds RANBP9 and SOS1 (Sus scrofa)
REACT:R-SPO-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)
RHEA:31160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH
RHEA:71497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in)
REACT:R-RNO-3465429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)
RHEA:18780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkylmercury + H(+) <=> an alkane + Hg(2+)
REACT:R-SPO-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Schizosaccharomyces pombe)
REACT:R-SSC-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Sus scrofa)
REACT:R-MMU-9706323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA2 (Mus musculus)
REACT:R-HSA-9685219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling) (Homo sapiens)
GO:0008881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate racemase activity
RHEA:10674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine dimer in DNA => cyclobutadithymidine in DNA
REACT:R-CFA-170044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Canis familiaris)
REACT:R-MMU-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Mus musculus)
RHEA:61284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cystine + O2 = (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)
REACT:R-DRE-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Danio rerio)
REACT:R-HSA-8865667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPA hydrolyses sterol esters to sterols and fatty acids (Homo sapiens)
RHEA:14493	skos:altLabel	"ADP-ribosyl glycohydrolase"
RHEA:14493	skos:altLabel	"dinitrogenase reductase activating glycohydrolase"
RHEA:14493	skos:prefLabel	"ADP-ribosyl-[dinitrogen reductase] hydrolase"
RHEA:14493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-ribosyl-[dinitrogen reductase] hydrolase"
RHEA:14493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] = ADP-D-ribose + L-arginyl-[dinitrogen reductase]
GO:0035758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCL21 binding
GO:0035758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine (C-C motif) ligand 21 binding
REACT:R-DDI-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Dictyostelium discoideum)
RHEA:70890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-serine(out) + Na(+)(out) <=> L-glutamine(out) + L-serine(in) + Na(+)(in)
REACT:R-RNO-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Rattus norvegicus)
REACT:R-BTA-373700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-9 binds DCC:DIP13alpha complex (Bos taurus)
REACT:R-CFA-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Canis familiaris)
RHEA:12969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sn-glycero-3-phosphodiester + H2O = an alcohol + H(+) + sn-glycerol 3-phosphate
RHEA:43854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-dotriacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + triacontanoyl-CoA
GO:0034927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrene 1,2-monooxygenase activity
REACT:R-GGA-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Gallus gallus)
GO:0098603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenol Se-methyltransferase activity
GO:0098603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AdoSeMet is converted to AdeSeHCys by MetTrans(1) (Homo sapiens)
REACT:R-GGA-5333051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA1 binds HSF1 (Gallus gallus)
REACT:R-DRE-8939706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) polyubiquitinates RUNX2 (Danio rerio)
REACT:R-DRE-170847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Danio rerio)
REACT:R-XTR-9750226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 binds IKBKB and CHUK (Xenopus tropicalis)
REACT:R-HSA-73945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAS-mediated dimerization of procaspase-8 (Homo sapiens)
REACT:R-CFA-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Canis familiaris)
REACT:R-SCE-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Saccharomyces cerevisiae)
REACT:R-GGA-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Gallus gallus)
RHEA:47979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O
RHEA:56220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP
RHEA:51520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + S-adenosyl-L-methionine = (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine
RHEA:28528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinyl-CoA + crotonobetaine => (R)-carnitine + crotonobetainyl-CoA
GO:0010180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioglucosidase binding
GO:0010180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myrosinase binding
REACT:R-DRE-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
REACT:R-DRE-9033491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Danio rerio)
RHEA:50245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-442291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV2 is a GEF for Rho/Rac family kinases (Sus scrofa)
RHEA:52083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-octadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + octadecanoate
REACT:R-DRE-9664855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Danio rerio)
RHEA:10112	skos:altLabel	"beta-thionase"
RHEA:10112	skos:altLabel	"methylcysteine synthase"
RHEA:10112	skos:prefLabel	"cystathionine beta-synthase"
RHEA:10112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cystathionine beta-synthase"
RHEA:10112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + L-serine = H2O + L,L-cystathionine
RHEA:10112	skos:altLabel	"serine sulfhydrase"
REACT:R-CEL-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Caenorhabditis elegans)
REACT:R-SSC-156526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Sus scrofa)
REACT:R-XTR-8982165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Xenopus tropicalis)
RHEA:43147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(22) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine
REACT:R-DRE-429683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Danio rerio)
REACT:R-SSC-6799409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates TP53 (Sus scrofa)
GO:0030753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity
GO:0030753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthotoxol 8-O-methyltransferase activity
GO:0030753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	XMT activity
GO:0030753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	furanocoumarin 8-O-methyl-transferase activity
GO:0030753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthotoxol methyltransferase activity
GO:0030753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity
GO:0030753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthotoxol O-methyltransferase activity
GO:0030753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxyfuranocoumarin 8-O-methyltransferase activity
GO:0030753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	furanocoumarin 8-methyltransferase activity
GO:0030753	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity
REACT:R-HSA-190429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c (Homo sapiens)
REACT:R-HSA-9033506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves AGPS (Homo sapiens)
REACT:R-RNO-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Rattus norvegicus)
REACT:R-SCE-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Saccharomyces cerevisiae)
GO:0010357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate solanesyltransferase activity
RHEA:51054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androst-1-ene-3,17-dione + AH2 => 5alpha-androstan-3,17-dione + A
REACT:R-BTA-5340195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4 binds DCA, CDCA, LCHA (Bos taurus)
REACT:R-DRE-8937442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)
REACT:R-SPO-6811414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF (Schizosaccharomyces pombe)
REACT:R-XTR-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Xenopus tropicalis)
REACT:R-HSA-5683930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WICH phosphorylates H2AFX on Y142 (Homo sapiens)
RHEA:30535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinate sulfoxide + H(+) + NADPH = biotin + H2O + NADP(+)
RHEA:36595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + NADP(+) = NADPH + sulfur
REACT:R-RNO-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Rattus norvegicus)
REACT:R-DRE-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Danio rerio)
REACT:R-SSC-5696564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP25 deubiquitinates DDX58 (Sus scrofa)
REACT:R-GGA-1227804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate (Gallus gallus)
RHEA:65978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	previtamin D3 => 7-dehydrocholesterol + hnu
RHEA:58363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[protein] + O2 <=> (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate
REACT:R-BTA-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Bos taurus)
REACT:R-SCE-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Saccharomyces cerevisiae)
REACT:R-BTA-1112727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serine phosphorylation of STATs (Bos taurus)
REACT:R-HSA-5637765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII (Homo sapiens)
REACT:R-GGA-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Gallus gallus)
RHEA:38518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)
REACT:R-XTR-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Xenopus tropicalis)
RHEA:57901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 => adenosine in U6 snRNA + CO2 + formaldehyde + succinate
REACT:R-HSA-8865050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)
REACT:R-GGA-380508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NuMA to the centrosomes (Gallus gallus)
RHEA:63907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-phenylpyruvate + H(+) <=> H2O + phenguignardate
RHEA:13058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylneuraminate 9-phosphate + H2O => an N-acylneuraminate + phosphate
REACT:R-DME-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Drosophila melanogaster)
RHEA:27988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methylglyoxal + NADPH => hydroxyacetone + NADP(+)
REACT:R-DRE-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Danio rerio)
REACT:R-BTA-2161651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGE2 is converted to PGF2a by CBR1 (Bos taurus)
REACT:R-BTA-8952996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 forms homodimers (Bos taurus)
RHEA:38938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:59664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellopentaose + O2 = D-cellopentaono-1,5-lactone + H2O2
RHEA:43867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)
RHEA:35936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + L-proline + L-tryptophan => 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)
REACT:R-DME-216202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMO changes conformation and is activated (Drosophila melanogaster)
RHEA:17244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-amino acid ester + H2O <=> an alcohol + an alpha-amino acid + H(+)
RHEA:36781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-alpha-D-perosamine
RHEA:56726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-all-trans-beta-carotene + A + H2O => AH2 + all-trans-beta-carotene + O2
RHEA:45992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O
RHEA:21498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + prenol => dimethylallyl diphosphate + H2O
RHEA:43776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine(in) = an N-(acyl)-sphingosylphosphocholine(out)
RHEA:57649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trichosetin => equisetin + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Canis familiaris)
REACT:R-HSA-9700154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds SHC1 (Homo sapiens)
REACT:R-MMU-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Mus musculus)
RHEA:71305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-methionine(in) + 2 Na(+)(in) => chloride(out) + L-methionine(out) + 2 Na(+)(out)
REACT:R-HSA-9026366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTF3-bound NTRK2 dimerizes (Homo sapiens)
RHEA:18796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate <=> D-ribose 5-phosphate
REACT:R-BTA-210294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-2 (Bos taurus)
REACT:R-SPO-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Schizosaccharomyces pombe)
GO:0002135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP binding
RHEA:35127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-D-glutamate(out) = L-alanyl-D-glutamate(in)
RHEA:20097	skos:altLabel	"D-mannonate hydro-lyase"
RHEA:20097	skos:prefLabel	"mannonate dehydratase"
RHEA:20097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannonate dehydratase"
RHEA:20097	skos:altLabel	"altronate hydrolase"
RHEA:20097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O
RHEA:20097	skos:altLabel	"mannonic hydrolase"
RHEA:54930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+) => 3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH
RHEA:18182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + glyoxylate + H2O => (S)-malate + CoA + H(+)
REACT:R-CFA-1981128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Canis familiaris)
RHEA:42511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-acetamido-2-oxohexanoate + H2O + NAD(+) <=> 5-acetamidopentanoate + CO2 + H(+) + NADH
RHEA:60303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:26190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP => 1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-RNO-266310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:spherical HDL complex <=> LCAT + spherical HDL (Rattus norvegicus)
REACT:R-SCE-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Saccharomyces cerevisiae)
REACT:R-MMU-9604328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates NOTCH4 (Mus musculus)
RHEA:21531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + H2O <=> [phosphate](n-1) + H(+) + phosphate
REACT:R-HSA-167077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
REACT:R-BTA-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Bos taurus)
REACT:R-CFA-216072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Canis familiaris)
REACT:R-SSC-2025723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the N-glycan precursor (Sus scrofa)
RHEA:16184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:48185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:53984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
REACT:R-RNO-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Rattus norvegicus)
REACT:R-HSA-560472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
REACT:R-HSA-3225867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of MINK1/TNIK is positively regulated by ROS (Homo sapiens)
REACT:R-PFA-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Plasmodium falciparum)
RHEA:26412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + N-acetyl-D-glucosamine 6-phosphate => H2O + N-acetyl-D-muramate 6-phosphate
GO:0050367	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kyotorphin-synthesizing enzyme activity
GO:0050367	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kyotorphin synthase activity
GO:0050367	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kyotorphin synthetase activity
GO:0050367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine-arginine ligase activity
GO:0050367	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine:L-arginine ligase (AMP-forming)
GO:0050367	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosyl-arginine synthase activity
REACT:R-RNO-8956140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 and UBD bind NUB1 and the 26S proteasome (Rattus norvegicus)
REACT:R-BTA-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Bos taurus)
REACT:R-RNO-163798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein Z to protein Z (Rattus norvegicus)
REACT:R-BTA-1564112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VI degradation by MMP2,9,11 (Bos taurus)
REACT:R-BTA-2465917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerisation of 11c-retinyl to at-retinyl (Bos taurus)
REACT:R-HSA-2012086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive dimerization of FGFR4 Y367C mutant (Homo sapiens)
REACT:R-DDI-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Dictyostelium discoideum)
REACT:R-DDI-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Dictyostelium discoideum)
REACT:R-GGA-373140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Gallus gallus)
REACT:R-DME-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Drosophila melanogaster)
REACT:R-DRE-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Danio rerio)
REACT:R-XTR-8987012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Xenopus tropicalis)
REACT:R-DME-9650858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Meglitinides bind ABCC8 (Drosophila melanogaster)
GO:0030281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of cutaneous appendage
REACT:R-SSC-6792871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNG1 recruits PP2A-PPP2R5C to MDM2 (Sus scrofa)
REACT:R-BTA-8952749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Bos taurus)
REACT:R-BTA-1433514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
RHEA:40712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate
REACT:R-DRE-143468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEOS oxidizes ethanol to acetaldehyde (Danio rerio)
RHEA:31654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine
REACT:R-CEL-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Caenorhabditis elegans)
REACT:R-CFA-173740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to C3(H2O) (Canis familiaris)
RHEA:48258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => (2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:71920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + succinate(out) => 3 Na(+)(in) + succinate(in)
RHEA:28075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfopropanediol + H2O + 2 NAD(+) => (2R)-3-sulfolactate + 3 H(+) + 2 NADH
REACT:R-CEL-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Caenorhabditis elegans)
RHEA:60046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP => beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose
REACT:R-HSA-8848124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAT3 (Homo sapiens)
REACT:R-HSA-203625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)
REACT:R-CFA-2162226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Canis familiaris)
RHEA:32792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ectoine(in) => L-ectoine(out)
RHEA:15761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH
RHEA:54258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[protein] + O2
REACT:R-BTA-2247512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Bos taurus)
RHEA:19058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxy polyunsaturated fatty acid + 2 glutathione => a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O
REACT:R-HSA-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Homo sapiens)
REACT:R-HSA-2691226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 HD domain mutants bind JAG1 (Homo sapiens)
RHEA:64236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrochrysone carboxyl-[ACP] + H2O = atrochrysone carboxylate + H(+) + holo-[ACP]
REACT:R-CFA-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Canis familiaris)
REACT:R-RNO-9693478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A agonists (Rattus norvegicus)
RHEA:37802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADH + O2 <=> 2 H2O + 2 NAD(+)
REACT:R-MMU-77608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of A1CF to stem-looped RNA (Mus musculus)
REACT:R-DRE-5654426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
REACT:R-DRE-6800794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 associates with CRADD (Danio rerio)
RHEA:39160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O
REACT:R-MMU-2473186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FSTL3 binds Activin (Mus musculus)
REACT:R-BTA-351894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of BAP31 (Bos taurus)
REACT:R-BTA-266310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:spherical HDL complex <=> LCAT + spherical HDL (Bos taurus)
REACT:R-DDI-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Dictyostelium discoideum)
REACT:R-DRE-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Danio rerio)
REACT:R-CFA-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Canis familiaris)
RHEA:40016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O => 13-epi-manool + diphosphate
REACT:R-GGA-2533950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP14, TMPRSS6 (Gallus gallus)
REACT:R-MMU-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Mus musculus)
RHEA:35303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisopentadecanoyl-CoA + NADP(+) = 3-oxoisopentadecanoyl-CoA + H(+) + NADPH
REACT:R-BTA-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Bos taurus)
RHEA:63378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Danio rerio)
REACT:R-HSA-1912407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 gene transcription (Homo sapiens)
REACT:R-DRE-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Danio rerio)
RHEA:67734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA => uridylyl-uridylyl-ribonucleotide-RNA
REACT:R-CFA-429571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Canis familiaris)
REACT:R-CEL-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Caenorhabditis elegans)
REACT:R-CFA-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
REACT:R-HSA-174255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation multiubiquitinated Cyclin A (Homo sapiens)
REACT:R-RNO-3341397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
REACT:R-BTA-9759202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Bos taurus)
REACT:R-HSA-4088130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds FOXM1 (Homo sapiens)
EC:1.1.1.296	skos:prefLabel	"dihydrocarveol dehydrogenase"
EC:1.1.1.296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrocarveol dehydrogenase"
EC:1.1.1.296	skos:altLabel	"carveol dehydrogenase"
REACT:R-HSA-9025969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)
RHEA:56834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6-trichlorohydroquinone + 2 glutathione => 2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+)
REACT:R-DME-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Drosophila melanogaster)
REACT:R-GGA-6814683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Gallus gallus)
RHEA:30193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,9'-di-cis-phytofluene + plastoquinol-9 => 15-cis-phytoene + plastoquinone-9
REACT:R-SSC-5668417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Sus scrofa)
REACT:R-DRE-2730849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT (Danio rerio)
REACT:R-HSA-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Homo sapiens)
RHEA:58663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine
RHEA:16881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate
RHEA:16881	skos:altLabel	"thiosulfate cyanide transsulfurase"
RHEA:16881	skos:altLabel	"rhodanese"
RHEA:16881	skos:altLabel	"thiosulfate thiotransferase"
RHEA:16881	skos:prefLabel	"thiosulfate sulfurtransferase"
RHEA:16881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiosulfate sulfurtransferase"
REACT:R-DME-8955844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBKS phosphorylates ribose to R5P (Drosophila melanogaster)
RHEA:21669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sn-glycerol 3-phosphate(out) => ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)
REACT:R-XTR-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Xenopus tropicalis)
REACT:R-CFA-5696914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP28 deubiquitinates CLSPN and MYC (Canis familiaris)
RHEA:49318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:29690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltoheptaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltohexaose
REACT:R-HSA-2574840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA facilitates AURKA autophosphorylation (Homo sapiens)
RHEA:40792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexacosanoyl-CoA => CoA + H(+) + hexacosanoate
RHEA:36520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexacosanoyl-CoA + malonyl-CoA => 3-oxooctacosanyol-CoA + CO2 + CoA
RHEA:35748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => 7-epizingiberene + diphosphate
REACT:R-GGA-209125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Gallus gallus)
RHEA:50836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate
REACT:R-CFA-9027281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Canis familiaris)
REACT:R-RNO-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Rattus norvegicus)
REACT:R-HSA-167121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent HIV-1 transcript (Homo sapiens)
GO:0034639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-amino acid efflux permease activity
GO:0034639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-amino acid export transporter activity
GO:0034639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-amino acid efflux transmembrane transporter activity
REACT:R-HSA-1222685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathelicidin LL-37 binds to bacterial cell wall (Homo sapiens)
REACT:R-SSC-203553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS binds NOSIP (Sus scrofa)
REACT:R-HSA-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Homo sapiens)
REACT:R-HSA-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Homo sapiens)
REACT:R-BTA-5687123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S115 MAPKAPK5 translocates to the cytosol (Bos taurus)
RHEA:37143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:44465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine
RHEA:57705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH
RHEA:41096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphing-4-enine-phosphocholine => H(+) + phosphocholine + sphing-4-enine
REACT:R-GGA-426223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cation influx mediated by TRPC3/6/7 (Gallus gallus)
RHEA:14471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-aminomuconate + 2 H(+) + NADH => 2-aminomuconate 6-semialdehyde + H2O + NAD(+)
RHEA:51474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Xenopus tropicalis)
REACT:R-HSA-1368087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene (Homo sapiens)
REACT:R-HSA-174931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Homo sapiens)
RHEA:48305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
REACT:R-RNO-204871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb2 (Rattus norvegicus)
RHEA:38660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)
REACT:R-DRE-9021306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds and inactivates C1r, C1s (Danio rerio)
RHEA:12858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-methyl-L-aspartate => L-glutamate
REACT:R-XTR-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Xenopus tropicalis)
REACT:R-CFA-202726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F11R dimerises (Canis familiaris)
REACT:R-RNO-2997709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO1 (Rattus norvegicus)
REACT:R-RNO-8855131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9 binds Clathrin-coated vesicles (Rattus norvegicus)
REACT:R-XTR-5577234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Xenopus tropicalis)
RHEA:13009	skos:prefLabel	"arylformamidase"
RHEA:13009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine
RHEA:13009	skos:altLabel	"formylkynureninase"
RHEA:13009	skos:altLabel	"formylase"
RHEA:13009	skos:altLabel	"kynurenine formamidase"
RHEA:13009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arylformamidase"
RHEA:51734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + meleagrin + S-adenosyl-L-homocysteine => glandicoline B + S-adenosyl-L-methionine
REACT:R-BTA-174963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1 acetylation (Bos taurus)
REACT:R-CFA-2130378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex to plasma membrane (Canis familiaris)
GO:0010181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavin mononucleotide binding
GO:0010181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN binding
REACT:R-SSC-8944250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXV (Sus scrofa)
RHEA:12551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis,4-trans-xanthoxin + NAD(+) <=> 2-cis-(+)-abscisic aldehyde + H(+) + NADH
RHEA:12323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-O-acetylnorajmaline + NADP(+) <=> 1,2-dihydrovomilenine + 2 H(+) + NADPH
REACT:R-BTA-2730863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 by PKC-theta (Bos taurus)
REACT:R-DME-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Drosophila melanogaster)
RHEA:11114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate => H2O + isochorismate
REACT:R-DME-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Drosophila melanogaster)
REACT:R-GGA-5654573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds SHC1 (Gallus gallus)
REACT:R-SSC-5649873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Sus scrofa)
RHEA:49484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate
REACT:R-BTA-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Bos taurus)
REACT:R-MMU-170843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 phosphorylates TGFBR1 (Mus musculus)
REACT:R-HSA-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Homo sapiens)
REACT:R-GGA-3232162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates MITF with SUMO1 (Gallus gallus)
REACT:R-XTR-8863101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPPL2a/b cleaves TNF(1-76) (Xenopus tropicalis)
RHEA:28017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + thiocyanate <=> methyl thiocyanate + S-adenosyl-L-homocysteine
REACT:R-SPO-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Schizosaccharomyces pombe)
REACT:R-SCE-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Saccharomyces cerevisiae)
REACT:R-SSC-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Sus scrofa)
REACT:R-HSA-1222384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutathione scavenges nitrosyl (Homo sapiens)
RHEA:70423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H2O = a carboxylate + CoA + H(+)
RHEA:62470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-5'-AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + H(+)
RHEA:70278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + raffinose <=> D-galactose + sucrose
REACT:R-GGA-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Gallus gallus)
REACT:R-CFA-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Canis familiaris)
REACT:R-DME-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Drosophila melanogaster)
RHEA:36255	skos:altLabel	"glyceryl etherase"
RHEA:36255	skos:altLabel	"glyceryl-ether cleaving enzyme"
RHEA:36255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O
RHEA:36255	skos:altLabel	"glyceryl-ether monooxygenase"
RHEA:36255	skos:prefLabel	"alkylglycerol monooxygenase"
RHEA:36255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkylglycerol monooxygenase"
RHEA:32778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate(out) + ATP + H2O <=> (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate
RHEA:32398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4S)-dihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH
REACT:R-DRE-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Danio rerio)
REACT:R-RNO-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Rattus norvegicus)
RHEA:32410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S,4S)-neoisodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH
RHEA:50056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate
RHEA:46425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0106357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-1-phosphate dehydrogenase [NAD+] activity
GO:0106357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH
RHEA:14478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:15888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propane-1,2-diol <=> (S)-lactaldehyde + H(+) + NADPH
REACT:R-CFA-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Canis familiaris)
RHEA:41528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-[ACP] + H(+) + NADH = NAD(+) + octanoyl-[ACP]
RHEA:70378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + dodecanoyl-CoA <=> CoA + H(+) + N-dodecanoyl-3-oxosphinganine
REACT:R-SSC-6786171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 deubiquitination by USP1:WDR48 (Sus scrofa)
REACT:R-MMU-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Mus musculus)
REACT:R-MMU-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Mus musculus)
RHEA:46602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[HPr protein]-O-phospho-L-serine + ADP + H(+) => [HPr protein]-L-serine + ATP
RHEA:47447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(7Z-hexadecenoyl)-CoA + CoA <=> (5Z)-tetradecenoyl-CoA + acetyl-CoA
REACT:R-RNO-3928656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves EPHB2 (Rattus norvegicus)
REACT:R-DME-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Drosophila melanogaster)
REACT:R-CFA-5692755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates MAPK6 (Canis familiaris)
REACT:R-DME-508369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Drosophila melanogaster)
REACT:R-MMU-73805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Mus musculus)
REACT:R-BTA-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Bos taurus)
GO:0090447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate 2-O-acyltransferase activity
RHEA:50571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]
RHEA:29579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(in) + H(+)(in) = Fe(2+)(out) + H(+)(out)
REACT:R-XTR-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Xenopus tropicalis)
REACT:R-HSA-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Homo sapiens)
REACT:R-MMU-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Mus musculus)
RHEA:65221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH
REACT:R-BTA-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Bos taurus)
RHEA:65842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + Mg(2+)(in) + phosphate(out) => ATP(out) + Mg(2+)(out) + phosphate(in)
RHEA:45625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine => AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]
REACT:R-DRE-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Danio rerio)
REACT:R-XTR-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Xenopus tropicalis)
RHEA:62378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + H(+) + pyruvate => 2,4-didehydro-3-deoxy-L-rhamnonate + H2O
REACT:R-DRE-8951951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds EP300 (Danio rerio)
GO:0050025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:oxygen oxidoreductase (deaminating)
GO:0050025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamic acid oxidase activity
GO:0050025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic dehydrogenase (acceptor)
GO:0050025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate (acceptor) dehydrogenase activity
GO:0050025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic acid oxidase activity
GO:0050025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate oxidase activity
GO:0050025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate oxidase activity
REACT:R-DDI-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Dictyostelium discoideum)
REACT:R-DRE-375140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds promyogenic cadherins (Danio rerio)
RHEA:69281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate => 3-hydroxypropyl isothiocyanate + sulfate
RHEA:12740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine <=> [PrdC protein]-L-selenocysteine/L-cysteine + D-proline
REACT:R-DRE-1112727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serine phosphorylation of STATs (Danio rerio)
GO:0047029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4-hydroxyphenyllactate dehydrogenase (NADPH) activity
GO:0047029	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aromatic 2-oxoacid reductase activity
GO:0047029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylpyruvate reductase activity
GO:0047029	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxyphenylpyruvate reductase activity
REACT:R-BTA-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Bos taurus)
REACT:R-XTR-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Xenopus tropicalis)
REACT:R-RNO-113429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongating transcript encounters a lesion in the template (Rattus norvegicus)
REACT:R-HSA-140214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates PMAIP1 (NOXA) expression (Homo sapiens)
REACT:R-CFA-5661240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCXR tetramer reduces L-xylulose to xylitol (Canis familiaris)
REACT:R-RNO-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Rattus norvegicus)
RHEA:47007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-threonyl-[protein] <=> L-threonyl-[protein] + phosphate
RHEA:66811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH <=> 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A
REACT:R-CEL-9641109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Caenorhabditis elegans)
RHEA:15150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pyridoxine 5'-phosphate => H2O2 + pyridoxal 5'-phosphate
RHEA:14543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + CoA + H(+) => choloyl-CoA + H2O
REACT:R-HSA-9750555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Homo sapiens)
REACT:R-SSC-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Sus scrofa)
REACT:R-BTA-9024326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Bos taurus)
REACT:R-DRE-420883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins act as GEFs for G alpha-t (Danio rerio)
RHEA:68298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-dodecanoyl-L-seryl-[protein] => dodecanoyl-CoA + L-seryl-[protein]
REACT:R-GGA-199299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO transcription factors (Gallus gallus)
RHEA:59758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine => L-arginine + S-adenosyl-L-methionine
RHEA:46798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:44232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-69754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes (Homo sapiens)
REACT:R-CFA-8878220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the NOTCH1 coactivator complex (Canis familiaris)
REACT:R-MMU-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Mus musculus)
REACT:R-RNO-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)
REACT:R-CFA-1878002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLTs transfer Xyl to core protein (Canis familiaris)
RHEA:29502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphate
REACT:R-CFA-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)
REACT:R-RNO-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Rattus norvegicus)
REACT:R-HSA-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Homo sapiens)
RHEA:59528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]
REACT:R-BTA-6806974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET dimers autophosphorylate (Bos taurus)
RHEA:44852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(5Z)-tetradecenoyl-(R)-carnitine
REACT:R-MMU-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-XTR-5654591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)
REACT:R-XTR-5654662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)
RHEA:54427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartyl-[protein] + NAD(+) <=> 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide
REACT:R-XTR-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Xenopus tropicalis)
RHEA:17224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O
REACT:R-SSC-139919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BIM to mitochondria (Sus scrofa)
REACT:R-CFA-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Canis familiaris)
REACT:R-SPO-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)
REACT:R-HSA-375384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bombesin-like receptors bind bombesin homologues (Homo sapiens)
RHEA:54365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetaldehyde => acetoin
RHEA:19250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
REACT:R-BTA-917888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF binds 2Fe3+ to form holoTF (Bos taurus)
REACT:R-XTR-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Xenopus tropicalis)
RHEA:24390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate + uracil => phosphate + uridine
RHEA:18964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allose + L-lysyl-[protein] <=> H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]
REACT:R-RNO-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Rattus norvegicus)
RHEA:15261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:50003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butane + H(+) + NADH + O2 <=> butan-1-ol + H2O + NAD(+)
RHEA:26229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranylgeranyl diphosphate reductase"
RHEA:26229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 NADP(+) + phytyl diphosphate = geranylgeranyl diphosphate + 3 H(+) + 3 NADPH
RHEA:26229	skos:altLabel	"geranylgeranyl reductase"
RHEA:26229	skos:prefLabel	"geranylgeranyl diphosphate reductase"
REACT:R-CEL-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)
REACT:R-HSA-6810158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB3 chromatin is activated (Homo sapiens)
GO:0008987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinolinate synthetase A activity
REACT:R-CFA-5218820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src kinases phosphorylate VAV (Canis familiaris)
REACT:R-SSC-4420143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SH2D2A (Sus scrofa)
RHEA:69822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hypotaurine + NADPH + O2 <=> H2O + NADP(+) + taurine
RHEA:72582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O <=> (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA
REACT:R-DRE-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)
REACT:R-DRE-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Danio rerio)
RHEA:21578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylcholine + CO2 => carnitine + H(+)
REACT:R-DDI-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Dictyostelium discoideum)
RHEA:33298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:68297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + L-seryl-[protein] => CoA + O-dodecanoyl-L-seryl-[protein]
RHEA:20962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O
REACT:R-SSC-164620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Sus scrofa)
RHEA:67120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:24978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-SPO-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Schizosaccharomyces pombe)
REACT:R-RNO-2750187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Rattus norvegicus)
REACT:R-BTA-390909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds hist (Bos taurus)
GO:0022884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macromolecule transmembrane transporter activity
REACT:R-CFA-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Canis familiaris)
REACT:R-XTR-8870732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSGs bind proteoglycans and TGF-beta1 (Xenopus tropicalis)
RHEA:11139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)
REACT:R-MMU-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Mus musculus)
RHEA:28918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) + H(+)(in) <=> 4-aminobutanoate(out) + H(+)(out)
RHEA:68346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',2'-cGAMP + 2 diphosphate => ATP + GTP
REACT:R-XTR-927813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)
REACT:R-DME-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Drosophila melanogaster)
RHEA:48651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:52521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:41872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)
RHEA:16718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + FAD + H(+) + H2O => cholate + FADH2
RHEA:66395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + prostaglandin E1(in) <=> ADP + H(+) + phosphate + prostaglandin E1(out)
REACT:R-GGA-5649673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyA from damaged DNA (Gallus gallus)
RHEA:64437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycylglycyl-L-isoleucine(out) + H(+)(out) => glycylglycyl-L-isoleucine(in) + H(+)(in)
GO:0042123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucanosyltransferase activity
RHEA:18874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-D-alanine + H2O => chloride + H(+) + NH4(+) + pyruvate
REACT:R-CEL-8943780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 recruits NuRD to PTEN gene (Caenorhabditis elegans)
REACT:R-DRE-3465545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Danio rerio)
RHEA:15777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanidinodeoxy-scyllo-inositol-4-phosphatase"
RHEA:15777	skos:prefLabel	"guanidinodeoxy-scyllo-inositol-4-phosphatase"
RHEA:15777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate
REACT:R-CEL-71335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)
REACT:R-HSA-9621048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPH1 gene expression (Homo sapiens)
REACT:R-SSC-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Sus scrofa)
RHEA:28713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out) => H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in)
RHEA:50733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-8850945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates PTEN (Drosophila melanogaster)
REACT:R-GGA-1433488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHP2 by SFKs (Gallus gallus)
RHEA:18126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a D-alpha-amino acid + H2O => a 2-oxocarboxylate + AH2 + NH4(+)
GO:1902122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA binding
GO:1902122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholic acid binding
RHEA:63367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2
RHEA:12258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-tyrosine + NADH => L-arogenate + NAD(+)
REACT:R-SSC-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Sus scrofa)
REACT:R-GGA-9750001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Gallus gallus)
RHEA:56760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-5324632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Danio rerio)
REACT:R-HSA-5686301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 binds SFTPAs (Homo sapiens)
RHEA:63017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)
RHEA:57517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0034803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-naphthoate 2,3-dioxygenase activity
REACT:R-DRE-1855180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Danio rerio)
RHEA:29472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + H2O => D-ribose + phosphate
REACT:R-DRE-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Danio rerio)
REACT:R-DME-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Drosophila melanogaster)
REACT:R-CFA-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Canis familiaris)
RHEA:30905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + spheroidene => demethylspheroidene + S-adenosyl-L-methionine
RHEA:41230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelate + O2 <=> 4-hydroxyphenylglyoxylate + H2O2
GO:0103028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	murein hydrolase activity
REACT:R-HSA-5675373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear DUSPs dephosphorylate MAPKs (Homo sapiens)
RHEA:12402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + nicotinate beta-D-ribonucleotide => beta-nicotinamide D-ribonucleotide + H2O
RHEA:52232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin a
REACT:R-CEL-5696197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Caenorhabditis elegans)
RHEA:48300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha
RHEA:16372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + NAD(+) <=> H(+) + NADH + pyruvate
REACT:R-CEL-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)
RHEA:54255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
RHEA:26397	skos:prefLabel	"crocetin dialdehyde synthase"
RHEA:26397	skos:altLabel	"zeaxanthin 7,8-dioxygenase"
RHEA:26397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"crocetin dialdehyde synthase"
RHEA:26397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 O2 = 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde
REACT:R-CFA-211948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 can N-demethylate loperamide (Canis familiaris)
RHEA:50799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin A2 <=> prostaglandin A2-S-(R)-glutathione
RHEA:53138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+)
REACT:R-DME-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Drosophila melanogaster)
RHEA:60981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxydodecanoate + NAD(+) => 12-oxododecanoate + H(+) + NADH
RHEA:46974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + bisanhydrobacterioruberin => A + dihydrobisanhydrobacterioruberin
REACT:R-RNO-5635865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 dissociates from ub-PTCH1 (Rattus norvegicus)
REACT:R-SSC-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Sus scrofa)
REACT:R-RNO-202241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SLP-76 to Gads (Rattus norvegicus)
REACT:R-DRE-399712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Danio rerio)
RHEA:58701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + NADPH + rifampicin => FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal
RHEA:47763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Drosophila melanogaster)
RHEA:39929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O
RHEA:66605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in double-stranded DNA + NH4(+)
REACT:R-DME-201630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Acinus (Drosophila melanogaster)
RHEA:30005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose
REACT:R-GGA-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Gallus gallus)
REACT:R-BTA-5668404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFA binds TNFR2 (Bos taurus)
GO:0050376	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucosamine 4-epimerase activity
GO:0050376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucosamine 4-epimerase activity
GO:0050376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucosamine epimerase activity
RHEA:71455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	goralatide + H2O = L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate
REACT:R-GGA-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Gallus gallus)
REACT:R-HSA-8938382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGALS3 gene expression is stimulated by RUNX1 and RUNX2 (Homo sapiens)
RHEA:30316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,7-dimethylxanthine + H(+) + NADH + O2 => 7-methylxanthine + formaldehyde + H2O + NAD(+)
RHEA:31483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol E + UDP-alpha-D-glucuronate = H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP
RHEA:15487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-homoaconitate + H2O => (2R,3S)-homoisocitrate
RHEA:34112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine
REACT:R-GGA-2485148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Gallus gallus)
REACT:R-CEL-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Caenorhabditis elegans)
REACT:R-CFA-2465938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates atROL taken up by Muller cells (Canis familiaris)
RHEA:43564	skos:prefLabel	"(5-formylfuran-3-yl)methyl phosphate transaminase"
RHEA:43564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine = [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate
RHEA:43564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(5-formylfuran-3-yl)methyl phosphate transaminase"
RHEA:43564	skos:altLabel	"[5-(hydroxymethyl)furan-3-yl]methyl phosphate transaminase"
RHEA:56030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)
REACT:R-BTA-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Bos taurus)
RHEA:12474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylamine + glyoxylate + H2O2 => H2O + N-ethylglycine + O2
RHEA:48719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 13-oxo-(9Z,11E)-octadecadienoate + H2O
RHEA:41636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + phosphate
RHEA:10097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + S-adenosyl-L-methionine => an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine
RHEA:21301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate
EC:1.14.13.217	skos:altLabel	"protoviolaceinate synthase"
EC:1.14.13.217	skos:prefLabel	"protodeoxyviolaceinate monooxygenase"
EC:1.14.13.217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protodeoxyviolaceinate monooxygenase"
REACT:R-CFA-444838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 1 binds relaxin 2 and 3 (Canis familiaris)
REACT:R-SPO-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Schizosaccharomyces pombe)
RHEA:14481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase"
RHEA:14481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
RHEA:14481	skos:prefLabel	"2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase"
RHEA:14481	skos:altLabel	"HK-MTPenyl-1-P phosphatase"
REACT:R-CFA-166795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Classical C3 convertase (C4b:C2a complex) (Canis familiaris)
RHEA:39751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate => 3'-phosphoadenylyl sulfate + glycolithocholate
REACT:R-SSC-6814153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADO oxidises 2AET to HTAU (Sus scrofa)
RHEA:30360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 => chlorophyllide b + 3 H2O + 2 NADP(+)
REACT:R-MMU-350901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is organified (Mus musculus)
EC:3.6.1.23	skos:altLabel	"dUTP pyrophosphatase"
EC:3.6.1.23	skos:altLabel	"desoxyuridine 5'-triphosphatase"
EC:3.6.1.23	skos:prefLabel	"dUTP diphosphatase"
EC:3.6.1.23	skos:altLabel	"dUTPase"
EC:3.6.1.23	skos:altLabel	"desoxyuridine 5'-triphosphate nucleotidohydrolase"
EC:3.6.1.23	skos:altLabel	"deoxyuridine-triphosphatase"
EC:3.6.1.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dUTP diphosphatase"
REACT:R-HSA-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Homo sapiens)
RHEA:34992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-ornithine(in) => L-arginine(in) + L-ornithine(out)
REACT:R-DRE-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Danio rerio)
REACT:R-BTA-3266566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Bos taurus)
REACT:R-DME-450595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR:mRNA complex translocates from the nucleus to the cytosol (Drosophila melanogaster)
REACT:R-RNO-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Rattus norvegicus)
REACT:R-XTR-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Xenopus tropicalis)
GO:0061598	skos:prefLabel	"molybdopterin adenylyltransferase"
GO:0061598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdopterin adenylyltransferase activity
GO:0061598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"molybdopterin adenylyltransferase"
GO:0061598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + molybdopterin = adenylyl-molybdopterin + diphosphate
REACT:R-SPO-77594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Schizosaccharomyces pombe)
REACT:R-MMU-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Mus musculus)
REACT:R-SSC-5205663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)
RHEA:72575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA
RHEA:17825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)
RHEA:66230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-DeltaC13-CoA + H2O2 => asc-C13-CoA + O2
RHEA:46366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:24238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide => 2 Fe(III)-[cytochrome c] + H2O + trimethylamine
GO:0018632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol 4-monooxygenase activity
RHEA:48485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a propanoate ester + H2O => an aliphatic alcohol + H(+) + propanoate
REACT:R-SSC-1973968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 4A and 103 bind CCR2 (Sus scrofa)
REACT:R-BTA-8983834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Bos taurus)
REACT:R-CFA-5694077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Canis familiaris)
RHEA:60225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate
REACT:R-SCE-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Saccharomyces cerevisiae)
RHEA:45475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate
REACT:R-MMU-9033516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)
RHEA:28108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)
REACT:R-CEL-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Caenorhabditis elegans)
REACT:R-DDI-9011595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Dictyostelium discoideum)
RHEA:55784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate = all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP
REACT:R-GGA-1912357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH ubiquitinates DTX (Gallus gallus)
REACT:R-HSA-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Homo sapiens)
RHEA:54009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
GO:0004392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	haem oxygenase (decyclizing) activity
GO:0004392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heme oxidase activity
GO:0004392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme oxygenase (decyclizing) activity
GO:0004392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	haem oxidase activity
GO:0004392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ORP33 proteins
GO:0004392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
GO:0004392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heme oxygenase activity
GO:0004392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	haem oxygenase activity
RHEA:70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]
RHEA:52543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + phosphate <=> alpha-D-ribose 1-phosphate + cytosine
RHEA:31579	skos:prefLabel	"9,12-octadecadienoate 8-hydroperoxide 8R-isomerase"
RHEA:31579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"9,12-octadecadienoate 8-hydroperoxide 8R-isomerase"
RHEA:31579	skos:altLabel	"(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming)"
RHEA:31579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate
REACT:R-SPO-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Schizosaccharomyces pombe)
RHEA:70966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-phenylalanine + H2O + O2 <=> 3-phenylpyruvate + H2O2 + NH4(+)
RHEA:13432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) <=> 4-CDP-2-C-methyl-D-erythritol + diphosphate
REACT:R-BTA-159005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)
REACT:R-CEL-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Caenorhabditis elegans)
RHEA:28109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol 1-phosphate + NAD(+) <=> H(+) + keto-D-tagatose 6-phosphate + NADH
RHEA:55842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate
RHEA:41849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-[ACP] + H(+) + NADPH => NADP(+) + octanoyl-[ACP]
RHEA:55470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-5693575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PKcs autophosphorylates (Canis familiaris)
REACT:R-HSA-9704655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 E binds BCL2L1 (Homo sapiens)
REACT:R-CFA-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Canis familiaris)
REACT:R-RNO-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Rattus norvegicus)
REACT:R-XTR-5690157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP16,USP21 deubiquitinate Histone H2A (Xenopus tropicalis)
REACT:R-DDI-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)
RHEA:41736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) = adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)
REACT:R-DDI-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Dictyostelium discoideum)
REACT:R-RNO-182993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL) (Rattus norvegicus)
RHEA:64418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,4-lactone + H(+) + NADPH => D-xylofuranose + NADP(+)
GO:0050030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-pipecolate:(acceptor) 1,6-oxidoreductase activity
GO:0050030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate dehydrogenase activity
GO:0050030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-pipecolate:acceptor 1,6-oxidoreductase activity
REACT:R-DRE-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Danio rerio)
REACT:R-XTR-9033533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Xenopus tropicalis)
RHEA:65583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + TTP <=> H(+) + phosphate + TDP
REACT:R-GGA-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Gallus gallus)
RHEA:61585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine
RHEA:35142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + demethoxycurcumin
RHEA:60657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline
REACT:R-MMU-264435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the COP1-p53 complex (Mus musculus)
RHEA:18446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
GO:0050839	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cell adhesion receptor activity
GO:0050839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAM binding
GO:0050839	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cell adhesion molecule activity
GO:0050839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesion molecule binding
GO:0050839	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adhesive extracellular matrix constituent
RHEA:44814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-11 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+)
REACT:R-CFA-879910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 is phosphorylated, activated (Canis familiaris)
REACT:R-XTR-6801808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A,REG3G binds bacterial peptidoglycan (Xenopus tropicalis)
REACT:R-DRE-141159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-mediated dimerization of procaspase-8 (Danio rerio)
REACT:R-RNO-390846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2D3,4 bind to DA (Rattus norvegicus)
REACT:R-SSC-3296301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCRL2 binds CCL19 (Sus scrofa)
RHEA:10102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + a sterol + H(+) => a sterol ester + H2O
RHEA:64766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol => S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine
RHEA:56704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate
RHEA:56704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-[(E)-2-isocyanoethenyl]-1H-indole synthase"
RHEA:56704	skos:prefLabel	"3-[(E)-2-isocyanoethenyl]-1H-indole synthase"
EC:3.4.11.3	skos:altLabel	"cystyl-aminopeptidase"
EC:3.4.11.3	skos:prefLabel	"cystinyl aminopeptidase"
EC:3.4.11.3	skos:altLabel	"oxytocinase"
EC:3.4.11.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cystinyl aminopeptidase"
EC:3.4.11.3	skos:altLabel	"cystine aminopeptidase"
REACT:R-GGA-354066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PTK2 to Focal complexes (Gallus gallus)
REACT:R-BTA-5683425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53BP1 at DNA DSBs (Bos taurus)
REACT:R-GGA-6784319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,TYK2 phosphorylate JAK1,TYK2 (Gallus gallus)
GO:0070123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor beta receptor activity, type III
GO:0070123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endoglin
GO:0070123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta ligand binding to type III receptor
GO:0070123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	betaglycan
GO:0070123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type III TGFbeta receptor activity
GO:0070123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type III TGF-beta receptor activity
GO:0070123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type III transforming growth factor beta receptor activity
RHEA:71132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-asparagine(out) + Na(+)(out) => H(+)(out) + L-asparagine(in) + Na(+)(in)
RHEA:72151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
REACT:R-BTA-8987070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Bos taurus)
REACT:R-CEL-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Caenorhabditis elegans)
RHEA:34466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycopalyl diphosphate <=> cis-abienol + diphosphate
REACT:R-RNO-73920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Rattus norvegicus)
GO:0031863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D2 receptor binding
GO:0031863	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	prostaglandin D2 receptor ligand
GO:0031863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostanoid DP receptor binding
REACT:R-RNO-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Rattus norvegicus)
REACT:R-HSA-9012203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-26A and B bind to the 3'UTR of the CHD11 mRNA (Homo sapiens)
RHEA:69300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = benzyl isothiocyanate + sulfate
RHEA:39381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH
RHEA:30456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O => (-)-geosmin
RHEA:56291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Schizosaccharomyces pombe)
RHEA:41177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine => Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+)
REACT:R-HSA-9634850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT (Homo sapiens)
RHEA:62600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate
RHEA:39198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetracosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytetracosanoyl-CoA + NADP(+)
GO:0102407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-2-glycerol-3-phosphate C22:0-DCA-CoA acyl transferase activity
RHEA:36150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + benzyl alcohol <=> benzyl acetate + CoA
REACT:R-MMU-1974676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta defensin 103 activates TLR1:TLR2 (Mus musculus)
REACT:R-DRE-72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of mRNA at the 3'-end (Danio rerio)
REACT:R-DRE-9705713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 dehydrogenates TEST to DHTEST (Danio rerio)
RHEA:62678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-thio-IMP + 7,8-dihydrofolate + H2O => 10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide
REACT:R-GGA-5654515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds HS (Gallus gallus)
REACT:R-DRE-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
REACT:R-CFA-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Canis familiaris)
RHEA:27696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + H2O => (2R,3R)-2,3-dihydroxy-3-methylpentanoate
REACT:R-RNO-140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Rattus norvegicus)
RHEA:59219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + H(+) <=> CO2 + skatole
RHEA:66912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenanthramide C + S-adenosyl-L-methionine = avenanthramide B + H(+) + S-adenosyl-L-homocysteine
RHEA:18435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanone + H2O2 + NH4(+) => cyclohexylamine + H2O + O2
REACT:R-CEL-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Caenorhabditis elegans)
REACT:R-MMU-3322025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-a (Mus musculus)
RHEA:35975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 = A + CO2 + H2O + succinate + verruculogen
RHEA:35975	skos:prefLabel	"verruculogen synthase"
RHEA:35975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"verruculogen synthase"
REACT:R-SSC-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Sus scrofa)
RHEA:17237	skos:altLabel	"FMN adenylyltransferase"
RHEA:17237	skos:prefLabel	"FAD synthase"
RHEA:17237	skos:altLabel	"FAD pyrophosphorylase"
RHEA:17237	skos:altLabel	"FADS"
RHEA:17237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FAD synthase"
RHEA:17237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + FMN + H(+) = diphosphate + FAD
RHEA:17237	skos:altLabel	"FAD diphosphorylase"
RHEA:17237	skos:altLabel	"flavin adenine dinucleotide synthetase"
REACT:R-MMU-1972385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-Ribosylation of HNP-1 (Mus musculus)
RHEA:45884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-CFA-380076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 1 (NK1) binds to substance P (Canis familiaris)
RHEA:17349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase"
RHEA:17349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate
RHEA:17349	skos:prefLabel	"3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase"
RHEA:59841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + syringate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate
RHEA:50956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine
REACT:R-MMU-981535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) binds C3bBb, C4bC2a (Mus musculus)
RHEA:45123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-ipsdienol + NAD(+) <=> H(+) + ipsdienone + NADH
REACT:R-HSA-5654125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol (Homo sapiens)
REACT:R-BTA-8987270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Bos taurus)
RHEA:47332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-354124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pPTK2 by SRC (Sus scrofa)
REACT:R-MMU-8869456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP4 deubiquitinate TRAF2,TRAF6 (Mus musculus)
REACT:R-HSA-5334097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3B:DNMT3L methylates cytosine in DNA (Homo sapiens)
RHEA:22857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-salutaridinol + acetyl-CoA => (7S)-O-acetylsalutaridinol + CoA
REACT:R-HSA-2130478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of invariant chain trimer and MHC II alpha beta dimer (Homo sapiens)
RHEA:29144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + 2 H(+)(in) + nitrate => a ubiquinone + 2 H(+)(out) + H2O + nitrite
RHEA:57243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + GMP <=> N(2)-(1-hydroxy-2-oxoethyl)-GMP
REACT:R-BTA-5686642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD52 promotes single strand annealing at resected DNA DSBs (Bos taurus)
REACT:R-HSA-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Homo sapiens)
RHEA:50909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 => A + a 3-demethylubiquinol + H2O
RHEA:68355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pppA(2'-5')pG <=> 3',2'-cGAMP + diphosphate
GO:0018701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichlorohydroquinone reductive dehalogenase activity
RHEA:47988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-galactonate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH
RHEA:47988	skos:prefLabel	"2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase"
RHEA:47988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase"
RHEA:11556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-carnitine 3-dehydrogenase"
RHEA:11556	skos:altLabel	"D-carnitine dehydrogenase"
RHEA:11556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH
RHEA:11556	skos:prefLabel	"(S)-carnitine 3-dehydrogenase"
REACT:R-DRE-1168635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (PKC-beta) phosphorylates CARMA1 (Danio rerio)
RHEA:11257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + limonin + UDP-alpha-D-glucose => glucosyl-limonin + 2 H(+) + UDP
RHEA:63536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bradykinin(1-8) + H2O = bradykinin(1-7) + L-phenylalanine
REACT:R-HSA-9706344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates GRB10 (Homo sapiens)
REACT:R-DRE-205118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 polyubiquitinates NRIF (Danio rerio)
REACT:R-DME-163214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)
EC:3.4.21.12	skos:altLabel	"alpha-lytic protease"
EC:3.4.21.12	skos:prefLabel	"alpha-lytic endopeptidase"
EC:3.4.21.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-lytic endopeptidase"
EC:3.4.22.14	skos:prefLabel	"actinidain"
EC:3.4.22.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"actinidain"
EC:3.4.22.14	skos:altLabel	"actinidin"
EC:3.4.22.14	skos:altLabel	"Actinidia anionic protease"
REACT:R-HSA-2318373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GUSB does not hydrolyse (HA)2 (Homo sapiens)
REACT:R-BTA-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Bos taurus)
REACT:R-RNO-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)
REACT:R-XTR-2426259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Xenopus tropicalis)
REACT:R-RNO-5691154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HFE binds TFRC dimer (Rattus norvegicus)
REACT:R-GGA-8853745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA3 (Gallus gallus)
REACT:R-XTR-2029270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLCgamma to membrane (Xenopus tropicalis)
REACT:R-GGA-9615348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR2 (Gallus gallus)
REACT:R-BTA-5654608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS bind to PPTN11 (Bos taurus)
GO:0030612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate reductase (thioredoxin) activity
RHEA:54889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-OPC-8 + ATP + CoA => AMP + diphosphate + OPC8-CoA
REACT:R-MMU-202710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MERTK receptor binds ligands (Gas6 or Protein S) (Mus musculus)
REACT:R-BTA-2993780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO1 from E1 to UBE2I (UBC9) (Bos taurus)
REACT:R-RNO-170799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Rattus norvegicus)
RHEA:47506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => chenodeoxycholate + NADP(+)
RHEA:59591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-ornithine <=> ADP + beta-alanyl-L-ornithine + H(+) + phosphate
RHEA:68262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(out) + Na(+)(out) => D-serine(in) + Na(+)(in)
RHEA:19033	skos:prefLabel	"N-acylglucosamine 2-epimerase"
RHEA:19033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-glucosamine = an N-acyl-D-mannosamine
RHEA:19033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acylglucosamine 2-epimerase"
RHEA:19033	skos:altLabel	"GlcNAc 2-epimerase"
RHEA:19033	skos:altLabel	"N-acetyl-D-glucosamine 2-epimerase"
REACT:R-BTA-1433454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GAB2 by SFKs (Bos taurus)
REACT:R-BTA-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Bos taurus)
EC:3.8.1.2	skos:altLabel	"L-2-haloacid dehalogenase"
EC:3.8.1.2	skos:altLabel	"2-haloacid halidohydrolase"
EC:3.8.1.2	skos:altLabel	"2-haloalkanoid acid halidohydrolase"
EC:3.8.1.2	skos:altLabel	"2-halocarboxylic acid dehalogenase II"
EC:3.8.1.2	skos:altLabel	"halocarboxylic acid halidohydrolase"
EC:3.8.1.2	skos:altLabel	"2-haloacid dehalogenase"
EC:3.8.1.2	skos:altLabel	"L-DEX"
EC:3.8.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-2-haloacid dehalogenase"
EC:3.8.1.2	skos:altLabel	"2-haloalkanoic acid dehalogenase"
EC:3.8.1.2	skos:altLabel	"DL-2-haloacid dehalogenase"
EC:3.8.1.2	skos:prefLabel	"(S)-2-haloacid dehalogenase"
RHEA:53308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)
REACT:R-XTR-2186771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 binds SMAD7 (Xenopus tropicalis)
RHEA:51500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-D-muramate 6-phosphate
RHEA:41320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-HSA-451758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p85 associates with both p-Nephrin and CD2AP (Homo sapiens)
REACT:R-XTR-9640237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)
REACT:R-GGA-8850961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREX2 binds PTEN and inhibits it (Gallus gallus)
RHEA:15439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + H(+) + NADPH => a long-chain fatty aldehyde + CoA + NADP(+)
RHEA:20209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + xylitol = ADP + H(+) + xylitol 5-phosphate
RHEA:20209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylitol kinase"
RHEA:20209	skos:prefLabel	"xylitol kinase"
RHEA:20209	skos:altLabel	"Xylitol phosphotransferase"
REACT:R-XTR-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Xenopus tropicalis)
REACT:R-DDI-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Dictyostelium discoideum)
RHEA:30968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9',15-tri-cis-zeta-carotene => 9,9'-di-cis-zeta-carotene
REACT:R-HSA-9756666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EOMES and TBXT (T, Brachyury) bind the SNAI1 gene (Homo sapiens)
RHEA:63028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+)
REACT:R-RNO-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Rattus norvegicus)
RHEA:43275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GD2 + H(+) + UDP
RHEA:45747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydropteroate + NAD(+) <=> 7,8-dihydropteroate + H(+) + NADH
REACT:R-RNO-8944230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Rattus norvegicus)
RHEA:30835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose
RHEA:71916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauronorcholate(out) => 2 Na(+)(in) + tauronorcholate(in)
RHEA:23515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose
RHEA:19913	skos:prefLabel	"3-oxoacyl-[acyl-carrier-protein] reductase (NADH)"
RHEA:19913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxoacyl-[acyl-carrier-protein] reductase (NADH)"
RHEA:19913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + NAD(+) = a 3-oxoacyl-[ACP] + H(+) + NADH
REACT:R-BTA-4420143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SH2D2A (Bos taurus)
REACT:R-SSC-879411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Sus scrofa)
RHEA:27948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) => dopamine + H2O + O2
REACT:R-MMU-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Mus musculus)
REACT:R-HSA-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Homo sapiens)
RHEA:15394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,6S)-2,6-diaminoheptanedioate => meso-2,6-diaminoheptanedioate
RHEA:33994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> alpha-copaene + diphosphate
REACT:R-XTR-427527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC dimethylates histone H3 at lysine-9 (Xenopus tropicalis)
REACT:R-BTA-9707586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM oxidises LDL,HDL (Bos taurus)
REACT:R-CEL-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Caenorhabditis elegans)
RHEA:16218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arabinono-1,4-lactone => H(+) + L-arabinonate
RHEA:51643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate
REACT:R-CFA-420214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The adrenomedullin receptor can bind adrenomedullin and intermedin (Canis familiaris)
RHEA:29064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + formate + H(+) => a menaquinol + CO2
RHEA:32809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate(out) => thiosulfate(in)
RHEA:53296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + NADP(+) = (2E,4E)-decadienoyl-CoA + H(+) + NADPH
RHEA:64705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphenylmethanol + NAD(+) => benzophenone + H(+) + NADH
RHEA:13790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)
RHEA:71936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate(out) + 2 Na(+)(out) => glycocholate(in) + 2 Na(+)(in)
REACT:R-BTA-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Bos taurus)
REACT:R-CFA-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Canis familiaris)
RHEA:18442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-dopachrome + H(+) => 5,6-dihydroxyindole + CO2
RHEA:54372	skos:prefLabel	"pristinol synthase"
RHEA:54372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate
RHEA:54372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pristinol synthase"
REACT:R-SSC-5654425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds SHC1 (Sus scrofa)
REACT:R-DRE-5610767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Danio rerio)
REACT:R-SSC-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)
REACT:R-PFA-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Plasmodium falciparum)
REACT:R-GGA-388817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICOS binds ICOSL/B7-H2 (Gallus gallus)
GO:0070034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TERC binding
GO:0070034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomerase RNA binding
REACT:R-RNO-2396561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GADS:SLP-76 to p-5Y-LAT (Rattus norvegicus)
RHEA:41639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + phosphate
RHEA:49454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O
REACT:R-DME-8957389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Drosophila melanogaster)
REACT:R-RNO-174235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdc20 (Rattus norvegicus)
REACT:R-CFA-2473594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP15 (Canis familiaris)
REACT:R-DME-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Drosophila melanogaster)
REACT:R-GGA-141156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL-mediated dimerization of procaspase-8 (Gallus gallus)
RHEA:51247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
RHEA:28529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + crotonobetainyl-CoA <=> (R)-carnitinyl-CoA + crotonobetaine
GO:0071859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuropeptide F receptor binding
REACT:R-GGA-2512800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1:ligand is endocytosed (Gallus gallus)
REACT:R-MMU-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Mus musculus)
GO:0106177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-GMP-AMP hydrolase activity
GO:0106177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP + 2 H2O = AMP + GMP + 2 H(+)
REACT:R-CEL-5618073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Caenorhabditis elegans)
REACT:R-HSA-6794351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHARPIN binds SHANK proteins (Homo sapiens)
REACT:R-DRE-174120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Danio rerio)
REACT:R-XTR-4093327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHA binds TIAM1 (Xenopus tropicalis)
EC:1.14.11.-	skos:prefLabel	"With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
EC:1.14.11.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
RHEA:14969	skos:prefLabel	"trans-aconitate 2-methyltransferase"
RHEA:14969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine
RHEA:14969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-aconitate 2-methyltransferase"
RHEA:61091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + 2-oxoglutarate + O2 <=> (2R,3R)-dihydroquercetin + CO2 + succinate
RHEA:55215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-hydroxyhexadecanoyl-CoA <=> formyl-CoA + pentadecanal
REACT:R-BTA-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Bos taurus)
REACT:R-GGA-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Gallus gallus)
REACT:R-RNO-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Rattus norvegicus)
REACT:R-DDI-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Dictyostelium discoideum)
REACT:R-HSA-9634897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds CDK5R1 gene promoter (Homo sapiens)
REACT:R-CFA-5654594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
GO:0045507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-25R
GO:0045507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-25 receptor activity
GO:0045507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-25 receptor activity
REACT:R-DRE-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Danio rerio)
REACT:R-HSA-167983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds TLR7, TLR8 ligands (Homo sapiens)
REACT:R-CFA-8985973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Canis familiaris)
REACT:R-SSC-5623521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A (Sus scrofa)
REACT:R-HSA-5654147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PLCG1 (Homo sapiens)
GO:0034597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity
GO:0034597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
GO:0034597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity
GO:0034597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)
REACT:R-MMU-5692283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Mus musculus)
RHEA:39277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoyl-CoA + NADP(+) => (2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH
REACT:R-DME-5684006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translocates NBN to the nucleus (Drosophila melanogaster)
REACT:R-DRE-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Danio rerio)
REACT:R-CFA-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Canis familiaris)
REACT:R-HSA-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Homo sapiens)
RHEA:47590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GQ1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E))
REACT:R-GGA-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Gallus gallus)
REACT:R-BTA-373086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR10 binds CCL27 and 28 ligands (Bos taurus)
RHEA:11686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine => methylarsonous acid + S-adenosyl-L-methionine
GO:0090417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methylnicotinate transporter activity
GO:0090417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylnicotinate transmembrane transporter activity
RHEA:29178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 O2 + ubiquinol-8 <=> 2 H(+) + 2 superoxide + ubiquinone-8
REACT:R-MMU-6807229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)
RHEA:41458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine
REACT:R-DRE-909718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of p-STAT1 homodimer (Danio rerio)
REACT:R-HSA-5666001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Profilin:G-actin binds MKL1 (Homo sapiens)
RHEA:70842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-histidine(out) + Na(+)(out) <=> L-arginine(out) + L-histidine(in) + Na(+)(in)
RHEA:64498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP] => 3,5,7,9,11-pentaoxododecanoyl-[ACP]
GO:0018823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dienoyl-CoA hydratase activity
GO:0018823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity
GO:0018823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity
GO:0018823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)
GO:0018823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity
GO:0018823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexa-1,5-dienecarbonyl-CoA hydratase activity
GO:0018823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity
RHEA:51955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-202534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of NEMO by TRAF6 (Sus scrofa)
RHEA:56493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hederagenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-77274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Sus scrofa)
RHEA:45299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingosylphosphocholine + H2O <=> a sphingoid base + H(+) + phosphocholine
REACT:R-BTA-5634221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 binds TRAF2 within TNFR1 signaling complex (Bos taurus)
REACT:R-DRE-446862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylated IRAK1 associates with TRAF6 (Danio rerio)
REACT:R-SSC-904864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Sus scrofa)
GO:0102824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity
REACT:R-XTR-1861789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Xenopus tropicalis)
REACT:R-DDI-2997709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO1 (Dictyostelium discoideum)
EC:3.2.1.89	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arabinogalactan endo-beta-1,4-galactanase"
EC:3.2.1.89	skos:altLabel	"galactanase"
EC:3.2.1.89	skos:prefLabel	"arabinogalactan endo-beta-1,4-galactanase"
EC:3.2.1.89	skos:altLabel	"endo-1,4-beta-galactanase"
EC:3.2.1.89	skos:altLabel	"arabinogalactanase"
RHEA:34493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP => H2O + UDP-N,N'-diacetylbacillosamine
REACT:R-DME-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Drosophila melanogaster)
RHEA:23054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit]
RHEA:46128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:34222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH
REACT:R-GGA-9008258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 binds ESR1:estrogen:TFGA gene (Gallus gallus)
REACT:R-BTA-8864343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD1 binds TFAP2 homo- and heterodimers (Bos taurus)
REACT:R-CFA-389758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)
GO:0070696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor protein serine/threonine kinase binding
RHEA:18574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + H(+) + O2 => chelirubine + H2O2
REACT:R-CFA-977605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H displaces Bb (Canis familiaris)
RHEA:61424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-cis-nepetalactol + NAD(+) = cis-cis-nepetalactone + H(+) + NADH
RHEA:48977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + pyocyanin
REACT:R-HSA-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)
RHEA:12015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine <=> ADP + H(+) + thiamine phosphate
REACT:R-BTA-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Bos taurus)
RHEA:25587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnose <=> beta-L-rhamnose
RHEA:49152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine
RHEA:15832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16alpha-hydroxysteroid <=> a 16beta-hydroxysteroid
REACT:R-DME-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Drosophila melanogaster)
RHEA:26047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:26047	skos:altLabel	"dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase"
RHEA:26047	skos:prefLabel	"glyceollin synthase"
RHEA:26047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyceollin synthase"
RHEA:38363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoylglycerol + H2O = glycerol + H(+) + octadecanoate
RHEA:29278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(in) + Na(+)(in) <=> L-isoleucine(out) + Na(+)(out)
GO:0033149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAT motif binding
RHEA:59799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-XTR-8874979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD3 binds GOLGB1 (Xenopus tropicalis)
RHEA:48176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Homo sapiens)
REACT:R-XTR-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Xenopus tropicalis)
REACT:R-SSC-168921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIF:activated TLR3/TLR4 complex recruits RIP1 (Sus scrofa)
RHEA:38115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-XTR-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Xenopus tropicalis)
GO:0015927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalase activity
GO:0070704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol desaturase activity
REACT:R-SSC-191656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Closure of gap junction (Sus scrofa)
RHEA:17051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + ubiquinol-9 => 3-demethylubiquinol-9 + S-adenosyl-L-methionine
RHEA:41635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-HSA-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Homo sapiens)
REACT:R-DRE-2130336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial proteolyis of Ii by aspartic proteases to lip22 (Danio rerio)
RHEA:28082	skos:altLabel	"crotonyl-CoA reductase (carboxylating)"
RHEA:28082	skos:prefLabel	"crotonyl-CoA carboxylase/reductase"
RHEA:28082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"crotonyl-CoA carboxylase/reductase"
RHEA:28082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ethylmalonyl-CoA + NADP(+) = (2E)-butenoyl-CoA + CO2 + NADPH
RHEA:28082	skos:altLabel	"CCR"
RHEA:51111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:68058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O
RHEA:59477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + 2 ATP + benzoate + L-phenylalanine => 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol
RHEA:70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O <=> dimethylallyl phosphate + H(+) + phosphate
REACT:R-DME-5656158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ elongates POLI-incorporated dNMP (Drosophila melanogaster)
REACT:R-CFA-388811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-1 homodimer (Canis familiaris)
RHEA:19220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)
REACT:R-MMU-5654734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Mus musculus)
RHEA:42250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexanoyl-[ACP] + CO2 + CoA => butanoyl-CoA + H(+) + malonyl-[ACP]
REACT:R-HSA-9664306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 binds CyslTR1,2 (Homo sapiens)
REACT:R-RNO-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Rattus norvegicus)
REACT:R-DRE-2395223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyridinoline cross-links (Danio rerio)
REACT:R-CFA-9011984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A is recruited to MYC and BCL2 genes (Canis familiaris)
RHEA:16983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + maleylacetate + NADH => 3-oxoadipate + NAD(+)
RHEA:18145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose = ADP + beta-D-fructose 1-phosphate + H(+)
RHEA:18145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ketohexokinase"
RHEA:18145	skos:prefLabel	"ketohexokinase"
RHEA:18145	skos:altLabel	"hepatic fructokinase"
RHEA:19348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate
RHEA:62094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O
REACT:R-RNO-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Rattus norvegicus)
REACT:R-RNO-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Rattus norvegicus)
REACT:R-BTA-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Bos taurus)
RHEA:43023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L,L-cystathionine <=> 2-aminoprop-2-enoate + L-homocysteine
RHEA:32767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-114264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAX to the mitochondria (Caenorhabditis elegans)
REACT:R-DDI-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Dictyostelium discoideum)
RHEA:34590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + pentalenolactone E <=> CO2 + pentalenolactone F + succinate
REACT:R-CFA-193665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYD88 dissociates (Canis familiaris)
REACT:R-CEL-9718360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide agonists (Caenorhabditis elegans)
RHEA:53985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
REACT:R-CFA-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Canis familiaris)
RHEA:28424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-5684108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 binds phosphorylated RBBP8 (Bos taurus)
GO:0031997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal myristoylation domain binding
GO:0010308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ARD activity
GO:0010308	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acireductone dioxygenase activity
GO:0010308	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity
GO:0010308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acireductone dioxygenase (Ni2+-requiring) activity
GO:0010308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)
GO:0010308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E-2 activity
RHEA:70958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-glutamate(in) <=> H(+)(out) + L-glutamate(out)
REACT:R-BTA-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Bos taurus)
REACT:R-SSC-5627275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOPC promotes translocation of CFTR to lysosomes (Sus scrofa)
REACT:R-RNO-5610737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH bind and ubiquitnate GLI1 (Rattus norvegicus)
RHEA:66400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycocholate(in) + H2O = ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate
RHEA:24666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2
REACT:R-CFA-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)
REACT:R-SPO-165179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TSC1:TSC2 complex (Schizosaccharomyces pombe)
RHEA:18727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + vanillin => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA
RHEA:67671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine
GO:0030184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide transmembrane transporter activity
RHEA:11212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole + O2 = 2-formamidobenzaldehyde
RHEA:11212	skos:prefLabel	"indole 2,3-dioxygenase"
RHEA:11212	skos:altLabel	"indole oxidase"
RHEA:11212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole 2,3-dioxygenase"
REACT:R-BTA-2160874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses (HA)50 (Bos taurus)
REACT:R-GGA-8983059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Gallus gallus)
RHEA:52885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-phenylhydroxylamine + 2 NADP(+) => 2 H(+) + 2 NADPH + nitrobenzene
REACT:R-SCE-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Saccharomyces cerevisiae)
RHEA:72443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-AMP + CoA = (E)-feruloyl-CoA + AMP + H(+)
GO:0034431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(5'-adenosyl)-hexaphosphatase activity
GO:0034431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity
GO:0034431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP(6)A hydrolase activity
GO:0034431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-6-A hydrolase activity
GO:0034431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-pentaphosphate + AMP + 2 H(+)
GO:0034431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP6A hydrolase activity
RHEA:36464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamate + H2O => glycine + L-glutamate
RHEA:26016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate
REACT:R-DRE-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Danio rerio)
REACT:R-MMU-70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine => urocanate + NH4+ (Mus musculus)
REACT:R-RNO-2213201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibres (Rattus norvegicus)
REACT:R-HSA-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Homo sapiens)
REACT:R-SSC-2168883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin:Hemoglobin binds CD163 (Sus scrofa)
RHEA:68391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5,6-dihydroxyindole-2-carboxylate + O2 <=> 2 H2O + 2 indole-5,6-quinone-2-carboxylate
REACT:R-DRE-2731078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 2, (4) bind TGFB1 (Danio rerio)
GO:0002039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p53 binding
REACT:R-DRE-380869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked dopamine loaded synaptic vesicle (Danio rerio)
REACT:R-GGA-5666160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)
REACT:R-DDI-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)
RHEA:65498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+) => 3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH
REACT:R-CFA-2424487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
REACT:R-RNO-1855219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)
RHEA:65571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine
REACT:R-SPO-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Schizosaccharomyces pombe)
RHEA:64862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine
REACT:R-BTA-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Bos taurus)
RHEA:20805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA
REACT:R-HSA-5660663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 cleaves IL1B precursor (Homo sapiens)
GO:0043015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma tubulin binding
GO:0043015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tubulin binding
RHEA:37119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Phe) {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine(37)-N}-methoxycarbonyltransferase"
RHEA:37119	skos:altLabel	"tRNA-yW synthesizing enzyme-4"
RHEA:37119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)
RHEA:37119	skos:prefLabel	"tRNA(Phe) {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine(37)-N}-methoxycarbonyltransferase"
RHEA:65843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(out) + Mg(2+)(out) + phosphate(in) <=> ATP(in) + Mg(2+)(in) + phosphate(out)
REACT:R-DRE-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Danio rerio)
RHEA:49382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:41036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA
REACT:R-CEL-141351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAOX:FAD oxidises NASPN to SPM (Caenorhabditis elegans)
RHEA:56907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-AMP + CoA <=> AMP + an acyl-CoA + H(+)
REACT:R-RNO-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
RHEA:54371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H(+) + pyruvate <=> acetoin + CO2
REACT:R-XTR-114263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization  of BAK at the mitochondrial membrane (Xenopus tropicalis)
RHEA:22142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside + phosphate => a nucleoside 5'-phosphate + H2O
RHEA:58357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + L-arginyl-[protein] + succinate
REACT:R-HSA-1236964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)
REACT:R-MMU-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Mus musculus)
RHEA:50857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
RHEA:37407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA
RHEA:37476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:30492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]
RHEA:60017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene B
GO:0052826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol hexakisphosphate 2-phosphatase activity
GO:0052826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1D-myo-inositol-hexakisphosphate 2-phosphohydrolase activity
GO:0052826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Homo sapiens)
REACT:R-MMU-158218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Mus musculus)
REACT:R-MMU-8852354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 facilitates proteasome-mediated degradation of TP53 (Mus musculus)
REACT:R-CFA-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Canis familiaris)
REACT:R-CFA-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Canis familiaris)
REACT:R-SPO-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Schizosaccharomyces pombe)
RHEA:66004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[methyl-Co(III) glycine betaine-specific corrinoid protein]--coenzyme M methyltransferase"
RHEA:66004	skos:prefLabel	"[methyl-Co(III) glycine betaine-specific corrinoid protein]--coenzyme M methyltransferase"
RHEA:66004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] = Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M
RHEA:24667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide
RHEA:42303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]
GO:0044197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHD binding
GO:0044197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rel homology domain binding
RHEA:13605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + O2 = 2 H2O + 2 L-dehydroascorbate
RHEA:48403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]
RHEA:65562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-glutamate => 2-oxoglutarate + L-kynurenine
RHEA:53572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-2997616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Dictyostelium discoideum)
GO:0102587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity
REACT:R-DDI-8878581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYRP1 oxidises DHICA to IQCA (Dictyostelium discoideum)
REACT:R-MMU-110251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of hypoxanthine by MPG glycosylase (Mus musculus)
REACT:R-MMU-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Mus musculus)
REACT:R-GGA-5654222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PLCG1 (Gallus gallus)
REACT:R-XTR-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Xenopus tropicalis)
RHEA:31312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)
RHEA:59883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + FMNH2 + O2 <=> 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O
REACT:R-CFA-3266557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I cleaves iC3b (Canis familiaris)
REACT:R-BTA-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Bos taurus)
REACT:R-SPO-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Schizosaccharomyces pombe)
RHEA:31947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-444202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR1 binds free fatty acids (Xenopus tropicalis)
RHEA:66654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	african-1-ene + diphosphate => (2E,6E)-farnesyl diphosphate
GO:0102149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesylcysteine lyase activity
RHEA:35774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-5-amino-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(+) + H2O
RHEA:25422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate => 3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O
GO:0106344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]
GO:0106344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP
REACT:R-DRE-8866308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL translocates from RER membrane to SER lumen (Danio rerio)
RHEA:26115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"epi-cedrol synthase"
RHEA:26115	skos:altLabel	"epicedrol synthase"
RHEA:26115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = diphosphate + epi-cedrol
RHEA:26115	skos:prefLabel	"epi-cedrol synthase"
RHEA:26115	skos:altLabel	"8-epicedrol synthase"
REACT:R-SSC-353125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteosome degrades ODC holoenzyme complex (Sus scrofa)
REACT:R-MMU-3296304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR31 is a receptor for 12(S)-HETE (Mus musculus)
RHEA:66883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-141341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMOX-3 oxidises SPN to SPM (Danio rerio)
RHEA:67510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine
RHEA:44147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-methionine <=> CoA + H(+) + N(alpha)-acetyl-L-methionine
GO:0043889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-O-geranylgeranylglycerylphosphate synthase activity
GO:0043889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGGPS
GO:0043889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGGP synthase activity
GO:0043889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-GGGP synthase activity
GO:0043889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-O-geranylgeranylglyceryl phosphate synthase activity
REACT:R-SSC-2186643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEN1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
REACT:R-GGA-6807565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY is transferred to the phagosome (Gallus gallus)
REACT:R-DDI-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)
REACT:R-XTR-400204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds RXRA (Xenopus tropicalis)
REACT:R-CFA-5607733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 binds CARD9 (Canis familiaris)
REACT:R-SSC-1028816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Sus scrofa)
REACT:R-CEL-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Caenorhabditis elegans)
REACT:R-HSA-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Homo sapiens)
REACT:R-SCE-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)
REACT:R-SSC-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Sus scrofa)
REACT:R-XTR-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Xenopus tropicalis)
REACT:R-MMU-3000399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates SP100 with SUMO1 (Mus musculus)
RHEA:15637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alginate](n) + GDP-alpha-D-mannuronate = [alginate](n+1) + GDP + H(+)
REACT:R-RNO-434989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA7A binds to PLXNC1 (Rattus norvegicus)
RHEA:41660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + NAD(+) = NADH + sanguinarine
REACT:R-HSA-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Homo sapiens)
REACT:R-DME-6805792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S291-PHF20 translocates to cytosol (Drosophila melanogaster)
RHEA:23393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(n-1) H2O + RNA(n) => n a ribonucleoside 5'-phosphate + n H(+)
REACT:R-BTA-77586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Bos taurus)
REACT:R-CFA-419981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Canis familiaris)
RHEA:55207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)
EC:6.5.1.-	skos:prefLabel	"Forming phosphoric ester bonds"
EC:6.5.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming phosphoric ester bonds"
REACT:R-CEL-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Caenorhabditis elegans)
REACT:R-GGA-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Gallus gallus)
RHEA:55471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-879562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Canis familiaris)
REACT:R-RNO-8851988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A2 binds T cell surface (Rattus norvegicus)
REACT:R-MMU-174441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Mus musculus)
REACT:R-RNO-2396370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds collagens II, III and V (Rattus norvegicus)
REACT:R-HSA-163602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 phosphorylated HSL monomers -> phosphorylated HSL dimer (Homo sapiens)
RHEA:49613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH
REACT:R-XTR-349455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MDM4 by ATM (Xenopus tropicalis)
REACT:R-GGA-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Gallus gallus)
RHEA:36726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + A + H2O <=> 2-phenylacetaldehyde + AH2 + NH4(+)
RHEA:53741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O => [Rab1 protein]-L-tyrosine + AMP + H(+)
RHEA:33395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester = GMP + N(alpha)-acetyl-L-lysine methyl ester
GO:0071885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein N-terminal methyltransferase"
GO:0071885	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	X-Pro-Lys N-terminal methyltransferase
GO:0071885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
GO:0071885	skos:prefLabel	"protein N-terminal methyltransferase"
GO:0071885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal protein N-methyltransferase activity
REACT:R-DRE-9604480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFkB complex translocates from the cytosol to the nucleus (Danio rerio)
RHEA:37590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + L-glutamate
REACT:R-BTA-2018659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Bos taurus)
REACT:R-DDI-163733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of FAS monomer gene by ChREBP:MLX (Dictyostelium discoideum)
REACT:R-HSA-167147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of abortive HIV-1 transcript from template (Homo sapiens)
REACT:R-CEL-391941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLT receptors can bind LTB4 (Caenorhabditis elegans)
REACT:R-DME-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Drosophila melanogaster)
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ca(2+)-transporting ATPase activity
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled calcium transmembrane transporter activity
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium-translocating P-type ATPase activity
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	calcium pump
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ca2+-transporting ATPase activity
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium efflux ATPase
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-transporting ATPase activity
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent calcium transmembrane transporter activity
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium transmembrane transporter activity, phosphorylative mechanism
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium transporting ATPase activity
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Homo sapiens)
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type calcium transporter activity
GO:0005388	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sarco(endo)plasmic reticulum Ca2+-ATPase
RHEA:39045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-983218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B:RAD51C binds single-stranded DNA (Homo sapiens)
REACT:R-DRE-174452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha on the C-strand of the telomere (Danio rerio)
REACT:R-DRE-380311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Plk1 to centrosomes (Danio rerio)
RHEA:57255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP <=> glycolate + GTP + H(+)
RHEA:51920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + AH2 = A + a quinol
GO:0034018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascopyrone isomerase activity
GO:0034018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascopyrone P tautomerase activity
GO:0034018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity
GO:0034018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascopyrone intramolecular oxidoreductase activity
GO:0034018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity
GO:0034018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APM tautomerase activity
GO:0034018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APTM
GO:0034018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascopyrone tautomerase activity
REACT:R-HSA-169683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
REACT:R-BTA-77323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Bos taurus)
RHEA:13285	skos:altLabel	"gamma-glutamyl-L-cysteine synthetase"
RHEA:13285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate--cysteine ligase"
RHEA:13285	skos:prefLabel	"glutamate--cysteine ligase"
RHEA:13285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate
RHEA:13285	skos:altLabel	"gamma-glutamylcysteine synthetase"
RHEA:20824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + ATP = ADP + AMP + H(+)
RHEA:20824	skos:prefLabel	"adenosine kinase"
RHEA:20824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosine kinase"
REACT:R-RNO-8848774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds DOK1 (Rattus norvegicus)
RHEA:50645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3-methylsulfanyl)propylmalate => 3-(3-methylsulfanyl)propylmalate
REACT:R-HSA-5251955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Homo sapiens)
REACT:R-HSA-8864737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A homodimer binds the VEGFA gene promoter (Homo sapiens)
REACT:R-MMU-70333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KHK dimer phosphorylates Fru to Fru 1-P (Mus musculus)
RHEA:19885	skos:altLabel	"berberine-bridge-forming enzyme"
RHEA:19885	skos:altLabel	"tetrahydroprotoberberine synthase"
RHEA:19885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"reticuline oxidase"
RHEA:19885	skos:prefLabel	"reticuline oxidase"
RHEA:19885	skos:altLabel	"berberine bridge enzyme"
RHEA:19885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + O2 = (S)-scoulerine + H(+) + H2O2
REACT:R-MMU-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Mus musculus)
REACT:R-BTA-8850997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 binds PTEN (Bos taurus)
RHEA:49203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate
RHEA:49918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in)
RHEA:40913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O
RHEA:57274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + methylglyoxal
RHEA:65948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 = A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O
RHEA:32677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + beta-D-glucose => alpha,alpha-trehalose + H2O
REACT:R-HSA-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Homo sapiens)
REACT:R-BTA-873951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1:HSP90 binds inactive NLRP3 (Bos taurus)
RHEA:63404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichloropyridine-2,5-diol + FADH2 + O2 = 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O
RHEA:42814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl octadecanoate + CoA => cholesterol + octadecanoyl-CoA
RHEA:43974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O
RHEA:14903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	casbene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-GGA-8987179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Gallus gallus)
RHEA:21803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin + L-ascorbate <=> all-trans-zeaxanthin + H2O + L-dehydroascorbate
REACT:R-CFA-442749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the nucleus (Canis familiaris)
REACT:R-SSC-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Sus scrofa)
RHEA:45632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
REACT:R-HSA-192434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of diacylglycerols by extracellular PTL:colipase (Homo sapiens)
REACT:R-DME-5607741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p52:RELB translocates from cytosol to nucleus (Drosophila melanogaster)
RHEA:18070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine => D-arginine
REACT:R-DME-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Drosophila melanogaster)
RHEA:57694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]
RHEA:33230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + H(+) <=> 4-hydroxystyrene + CO2
RHEA:28154	skos:altLabel	"3-deoxy-D-manno-oct-2-ulosonic acid transferase"
RHEA:28154	skos:prefLabel	"(Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase"
RHEA:28154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase"
RHEA:28154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:28154	skos:altLabel	"Kdo transferase"
RHEA:28154	skos:altLabel	"3-deoxy-manno-octulosonic acid transferase"
REACT:R-HSA-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Homo sapiens)
REACT:R-SSC-917811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3-like proteins reduce Fe3+ to Fe2+ (Sus scrofa)
REACT:R-MMU-9661723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)
RHEA:12223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-leucine + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)
RHEA:41952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase"
RHEA:41952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
RHEA:41952	skos:prefLabel	"[amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase"
RHEA:28834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate(in) + H(+)(in) <=> D-gluconate(out) + H(+)(out)
REACT:R-CFA-8858270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HILPDA binds lipid droplets (Canis familiaris)
RHEA:63596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine
RHEA:64782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + benzylthiol => S-benzyl-L-cysteine
REACT:R-RNO-1168445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B binds the GH receptor complex (Rattus norvegicus)
RHEA:50434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + prostaglandin H1 => AH2 + prostaglandin G1
RHEA:69306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => (Z)-glucotropeolin + H2O
REACT:R-MMU-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Mus musculus)
REACT:R-RNO-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Rattus norvegicus)
REACT:R-BTA-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Bos taurus)
REACT:R-RNO-5693539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of DNA and formation of Holliday structures following repair synthesis (Rattus norvegicus)
RHEA:56732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dihydroxy-all-trans-beta-carotene = echinenone + H2O
RHEA:30501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylpropanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-valine
REACT:R-DRE-8855111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds PCSK9 (Danio rerio)
RHEA:52161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime => (Z)-phenylacetaldehyde oxime
RHEA:16514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + O2 => acetate + CO2 + H2O
REACT:R-SSC-76386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 S-demethylates 6MMP (Sus scrofa)
RHEA:12620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-alpha-D-galactosamine <=> ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate
REACT:R-HSA-9694377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pp1a cleaves itself (Homo sapiens)
REACT:R-MMU-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Mus musculus)
REACT:R-XTR-114670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binds to vWF:Collagen complex (Xenopus tropicalis)
EC:5.99.1.-	skos:prefLabel	"Other isomerases"
EC:5.99.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other isomerases"
RHEA:17703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate => ATP + geranoyl-CoA + hydrogencarbonate
RHEA:72171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurohyocholate(out) = 2 Na(+)(in) + taurohyocholate(in)
REACT:R-DME-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Drosophila melanogaster)
EC:7.1.1.-	skos:prefLabel	"Hydron translocation or charge separation linked to oxidoreductase reactions"
EC:7.1.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hydron translocation or charge separation linked to oxidoreductase reactions"
REACT:R-XTR-3240295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Xenopus tropicalis)
REACT:R-CEL-112436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin complex (Caenorhabditis elegans)
REACT:R-DRE-158419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Danio rerio)
RHEA:65088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-201677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Danio rerio)
RHEA:28470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine(in) = pyridoxine(out)
RHEA:33577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a mannosylinositol-1-phosphophytoceramide + H2O => an inositol-1-phosphophytoceramide + beta-D-mannose
REACT:R-DRE-351987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A6-mediated uptake of taurine and beta-alanine (Danio rerio)
RHEA:44113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + nonan-1-ol => CoA + nonyl hexadecanoate
REACT:R-HSA-1989774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of AGT (Homo sapiens)
REACT:R-GGA-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Gallus gallus)
GO:0120284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trp binding
GO:0120284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan binding
REACT:R-MMU-2213240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of disulphide bonds in MHC II antigens (Mus musculus)
REACT:R-DRE-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Danio rerio)
REACT:R-DRE-2318623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan binds Hyaluronan and HAPLN1 (Danio rerio)
REACT:R-CFA-2984258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 phosphorylates NEK6/NEK7 (Canis familiaris)
REACT:R-CEL-373747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of nephrin by FYN (Caenorhabditis elegans)
REACT:R-CFA-508451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B is phosphorylated (Canis familiaris)
REACT:R-HSA-196026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dab2 is recruited to the junctional plaques (Homo sapiens)
RHEA:71077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-cystine(in) => L-arginine(in) + L-cystine(out)
REACT:R-HSA-9730483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 nsp16 binds to U1 snRNA (Homo sapiens)
REACT:R-CEL-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Caenorhabditis elegans)
RHEA:60169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP => a fatty acyl monophosphate + ADP
RHEA:40868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + FAD + H(+) => (2E,9E)-octadecadienoyl-CoA + FADH2
GO:0004481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylene-fatty-acyl-phospholipid synthase"
GO:0004481	skos:altLabel	"unsaturated-phospholipid methyltransferase"
GO:0004481	skos:prefLabel	"methylene-fatty-acyl-phospholipid synthase"
GO:0004481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylene-fatty-acyl-phospholipid synthase activity
GO:0004481	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	unsaturated-phospholipid methyltransferase activity
GO:0004481	skos:altLabel	"cyclopropane synthetase"
GO:0004481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine
GO:0004481	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclopropane synthetase activity
GO:0004481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)
RHEA:28674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate
RHEA:56213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:amino acid symporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	threonine/serine:sodium symporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/excitatory amino acid symporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium/excitatory amino acid cotransporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	isoleucine/valine:sodium symporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	insulin-activated sodium/amino acid transporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	insulin-activated sodium:amino acid transporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	insulin-activated sodium:amino acid symporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium/amino acid transporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glutamate/aspartate:sodium symporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium:amino acid transporter activity
GO:0005283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid:sodium symporter activity
RHEA:29327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in)
REACT:R-SSC-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Sus scrofa)
REACT:R-HSA-5695964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD14B hydrolyses PNPB (Homo sapiens)
RHEA:24139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a primary amine <=> a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)
RHEA:64883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP + H2O <=> CMP + H(+) + phosphate
REACT:R-PFA-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Plasmodium falciparum)
RHEA:54632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + tetradecanoyl-CoA = 2-hydroxytetradecanoyl-CoA + CO2 + succinate
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP27A1
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP27A
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanetriol 26-monooxygenase activity
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sterol 26-hydroxylase activity
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol 27-hydroxylase activity
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholestanetriol 26-hydroxylase activity
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol 27-hydroxylase activity
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity
GO:0047749	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 27A1' activity
RHEA:33346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 <=> 2-iminoacetate + H2O2
REACT:R-DRE-8949659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Danio rerio)
REACT:R-BTA-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Bos taurus)
REACT:R-DRE-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Danio rerio)
REACT:R-CFA-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Canis familiaris)
REACT:R-GGA-6781814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 deubiquitinates RNF123 (Gallus gallus)
EC:3.4.19.3	skos:altLabel	"pyrrolidone carboxyl peptidase"
EC:3.4.19.3	skos:altLabel	"5-oxoprolyl-peptidase"
EC:3.4.19.3	skos:altLabel	"pyroglutamyl aminopeptidase"
EC:3.4.19.3	skos:altLabel	"PYRase"
EC:3.4.19.3	skos:prefLabel	"pyroglutamyl-peptidase I"
EC:3.4.19.3	skos:altLabel	"pyrrolidone-carboxylate peptidase"
EC:3.4.19.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyroglutamyl-peptidase I"
REACT:R-DME-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Drosophila melanogaster)
REACT:R-CEL-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-SPO-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Schizosaccharomyces pombe)
REACT:R-MMU-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Mus musculus)
RHEA:11681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + XMP => AMP + diphosphate + GMP + 2 H(+) + L-glutamate
RHEA:31516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-apo-beta-carotenal + H2O + NAD(+) => 2 H(+) + NADH + neurosporaxanthin
REACT:R-HSA-9712199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds the olfactory CNG channel (Homo sapiens)
REACT:R-HSA-1236398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds NRGs or EGF-like ligands (Homo sapiens)
REACT:R-DRE-1028817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Danio rerio)
REACT:R-CEL-5669250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates FLNA (Caenorhabditis elegans)
RHEA:40113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate + CoA + H(+) => butanoyl-CoA + H2O
REACT:R-HSA-5635843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI translocates to the nucleus (Homo sapiens)
RHEA:23543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Glu)
RHEA:35721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-versiconol + acetate + H(+) => (3S)-versiconol acetate + H2O
REACT:R-CFA-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Canis familiaris)
REACT:R-RNO-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)
GO:0102869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyflavone-glucosyltransferase activity
RHEA:37760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-GGA-5665998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 binds SRF (Gallus gallus)
REACT:R-XTR-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-SPO-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Schizosaccharomyces pombe)
REACT:R-HSA-5621615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD209 binds ICAM3 (Homo sapiens)
RHEA:48406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein] => apo-[aryl-carrier protein] + CoA
REACT:R-MMU-9645442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Mus musculus)
RHEA:68473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => (E)-alpha-bisabolene + diphosphate
REACT:R-HSA-418576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 1:Gq complex (Homo sapiens)
RHEA:39047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-8864105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 binds ERBB2:EGFR heterodimers (Xenopus tropicalis)
REACT:R-MMU-8948224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)
REACT:R-CEL-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Caenorhabditis elegans)
RHEA:70290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3,4,6-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)
REACT:R-SPO-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Schizosaccharomyces pombe)
REACT:R-XTR-8871260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD2 (Xenopus tropicalis)
RHEA:39413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA
REACT:R-XTR-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Xenopus tropicalis)
RHEA:57683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:37068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
RHEA:62545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin => dihydroouabagenin + 2 Fe(III)-[cytochrome c]
GO:0050292	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 9-alpha-hydroxylase activity
GO:0050292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 9-alpha-monooxygenase activity
GO:0050292	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 9alpha-hydroxylase activity
GO:0050292	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 9alpha-monooxygenase activity
GO:0050292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 9a-monooxygenase activity
GO:0050292	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)
REACT:R-DRE-9010872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 binds Dystroglycan (Danio rerio)
REACT:R-XTR-2064417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-1 (TJP1) (Xenopus tropicalis)
RHEA:70256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine
RHEA:56545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-MMU-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Mus musculus)
REACT:R-BTA-9686920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 ubiquitinates RIPK3 at K363 (Bos taurus)
REACT:R-XTR-5218806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN autophosphorylates (Xenopus tropicalis)
REACT:R-DME-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Drosophila melanogaster)
REACT:R-HSA-8865613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Homo sapiens)
REACT:R-HSA-3700984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members stimulate BAX transcription (Homo sapiens)
REACT:R-CFA-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Canis familiaris)
REACT:R-DDI-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Dictyostelium discoideum)
RHEA:49281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 + phenol => catechol + FAD + H(+) + H2O
RHEA:52513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + trans-4-hydroxy-L-proline => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
RHEA:62679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide <=> 6-thio-IMP + 7,8-dihydrofolate + H2O
REACT:R-SSC-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Sus scrofa)
RHEA:28093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
REACT:R-HSA-5693148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDK phosphorylates BCKDH (Homo sapiens)
REACT:R-CFA-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Canis familiaris)
REACT:R-DME-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)
RHEA:45910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroeremomycin + dTDP + H(+) => chloroorienticin B + dTDP-beta-L-vancosamine
REACT:R-XTR-373813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR2 binds ligands CXCL1 to 7 (Xenopus tropicalis)
RHEA:69645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2
RHEA:40597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + dodecanedioate + H(+) => dodecanedioyl-CoA + H2O
REACT:R-CFA-421836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Vesicle Uncoating (Canis familiaris)
REACT:R-BTA-5654647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
RHEA:54904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH = (9Z)-hexadecenoyl-[ACP] + NAD(+)
REACT:R-MMU-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Mus musculus)
GO:0047980	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoylglycine amidohydrolase activity
GO:0047980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hippurate hydrolase activity
GO:0047980	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-benzoylamino-acid amidohydrolase activity
GO:0047980	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hippuricase activity
RHEA:37803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
EC:3.1.3.73	skos:prefLabel	"adenosylcobalamin/alpha-ribazole phosphatase"
EC:3.1.3.73	skos:altLabel	"alpha-ribazole phosphatase"
EC:3.1.3.73	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylcobalamin/alpha-ribazole phosphatase"
EC:3.1.3.73	skos:altLabel	"adenosylcobalamin phosphatase"
REACT:R-GGA-376886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Efflux of glucose and orthophosphate from the endoplasmic reticulum (Gallus gallus)
RHEA:44987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 3-methylbutanoyl-CoA <=> CoA + O-3-methylbutanoyl-(R)-carnitine
RHEA:57455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine
RHEA:70412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetyl-CoA + H2O => 4-hydroxyphenylacetate + CoA + H(+)
REACT:R-SSC-444572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zinc is an agonist of GPR39 (Sus scrofa)
REACT:R-BTA-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Bos taurus)
REACT:R-CFA-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Canis familiaris)
REACT:R-BTA-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Bos taurus)
RHEA:62179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-glucose + H2O <=> alpha-D-glucose 1-phosphate + GMP + 2 H(+)
RHEA:53217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-phenylalanine = 2-phenylethylamine + CO2
GO:0050174	skos:altLabel	"L-phenylalanine carboxy-lyase"
GO:0050174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine decarboxylase activity
GO:0050174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine decarboxylase"
GO:0050174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine carboxy-lyase (phenylethylamine-forming)
GO:0050174	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aromatic L-amino acid decarboxylase activity
GO:0050174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine decarboxylase activity
GO:0050174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine carboxy-lyase activity
GO:0050174	skos:altLabel	"L-phenylalanine decarboxylase"
GO:0050174	skos:prefLabel	"phenylalanine decarboxylase"
REACT:R-HSA-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Homo sapiens)
REACT:R-RNO-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Rattus norvegicus)
REACT:R-SPO-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Schizosaccharomyces pombe)
RHEA:40281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-dodecanoyl-R-carnitine => (R)-carnitine + dodecanoyl-CoA
GO:0098616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenate adenylyltransferase (ATP) activity
GO:0098616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2SeO4 is converted to APSe by PAPSS1,2 (Homo sapiens)
RHEA:44764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Sus scrofa)
RHEA:12527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate + NADP(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADPH
REACT:R-CEL-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Caenorhabditis elegans)
RHEA:31338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin cytosine dinucleotide
REACT:R-BTA-114261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-7 by the apoptosome (Bos taurus)
REACT:R-GGA-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Gallus gallus)
GO:0004602	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	non-selenium glutathione peroxidase activity
GO:0004602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GSH peroxidase activity
GO:0004602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione peroxidase activity
GO:0004602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	selenium-glutathione peroxidase activity
GO:0004602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:hydrogen-peroxide oxidoreductase activity
GO:0004602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced glutathione peroxidase activity
RHEA:19407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citryl-CoA + acetate => acetyl-CoA + citrate
RHEA:53677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
REACT:R-GGA-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Gallus gallus)
REACT:R-GGA-9701531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727 STAT3 is acetylated (Gallus gallus)
REACT:R-CFA-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Canis familiaris)
RHEA:12066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate + 2 H(+) + NADH => 5-oxopentanoate + H2O + NAD(+)
RHEA:50646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-methylsulfanyl)propylmalate => 2-(3-methylsulfanyl)propylmalate
RHEA:23288	skos:altLabel	"aldehyde dehydrogenase (acylating)"
RHEA:23288	skos:prefLabel	"acetaldehyde dehydrogenase (acetylating)"
RHEA:23288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH
RHEA:23288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetaldehyde dehydrogenase (acetylating)"
RHEA:23288	skos:altLabel	"acylating acetaldehyde dehydrogenase"
RHEA:64672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(methylsulfanyl)acetyl-CoA + butan-1-ol = butyl 2-(methylsulfanyl)acetate + CoA
REACT:R-SSC-1295622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds CBL (Sus scrofa)
RHEA:40719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione = an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)
REACT:R-HSA-9026918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA (Homo sapiens)
REACT:R-HSA-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Homo sapiens)
RHEA:23463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl cetraxate + H2O <=> benzyl alcohol + cetraxate + H(+)
RHEA:55615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O <=> 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)
RHEA:50944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + NAD(+) = (E)-cinnamate + H(+) + NADH
RHEA:41793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[ACP] + malonyl-CoA => CoA + malonyl-[ACP]
RHEA:32528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose + phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine
REACT:R-GGA-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Gallus gallus)
REACT:R-GGA-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Gallus gallus)
EC:1.3.5.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protoporphyrinogen IX dehydrogenase (quinone)"
EC:1.3.5.3	skos:prefLabel	"protoporphyrinogen IX dehydrogenase (quinone)"
EC:1.3.5.3	skos:altLabel	"protoporphyrinogen IX dehydrogenase (menaquinone)"
REACT:R-HSA-2213235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)
REACT:R-MMU-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Mus musculus)
REACT:R-RNO-193694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)
REACT:R-BTA-388503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxytocin receptor bind oxytocin (Bos taurus)
REACT:R-SSC-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Sus scrofa)
REACT:R-CFA-5691381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYSM1 deubiquitinates Histone H2A (Canis familiaris)
RHEA:49078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5-oxide + FMN + H(+) + H2O => dibenzothiophene + FMNH2 + O2
RHEA:65910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanine + xanthurenate => 3-hydroxy-L-kynurenine + pyruvate
REACT:R-BTA-1605632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Both hexosaminidase A and B can cleave GalNAc from globoside (Bos taurus)
REACT:R-RNO-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Rattus norvegicus)
REACT:R-DRE-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Danio rerio)
REACT:R-DRE-174367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCL ligates L-Glu to L-Cys (Danio rerio)
REACT:R-XTR-5666160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates DIAPH2-2 at kinetochores (Xenopus tropicalis)
GO:0016714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With reduced pteridine as one donor, and incorporation of one atom of oxygen"
GO:0016714	skos:prefLabel	"With reduced pteridine as one donor, and incorporation of one atom of oxygen"
GO:0016714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
REACT:R-HSA-9698033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)
REACT:R-CFA-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Canis familiaris)
RHEA:45472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate
REACT:R-XTR-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Xenopus tropicalis)
REACT:R-GGA-9010872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 binds Dystroglycan (Gallus gallus)
REACT:R-DRE-936380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PIN1 with p-IRF3 (Danio rerio)
REACT:R-HSA-912527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
REACT:R-RNO-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Rattus norvegicus)
REACT:R-SSC-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Sus scrofa)
REACT:R-GGA-9629149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves thymine glycol from damaged DNA (Gallus gallus)
REACT:R-HSA-8940388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPLD1 hydrolyses GPI-anchors from proteins (Homo sapiens)
REACT:R-XTR-8944223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type V (Xenopus tropicalis)
REACT:R-XTR-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Xenopus tropicalis)
GO:0022810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	membrane potential driven uniporter activity
GO:0022810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	porter
REACT:R-HSA-9015111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors binds Xa (Homo sapiens)
REACT:R-MMU-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Mus musculus)
GO:0030343	skos:altLabel	"vitamin D2 25-hydroxylase"
GO:0030343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholecalciferol 25-hydroxylase activity
GO:0030343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vitamin D 25-hydroxylase"
GO:0030343	skos:prefLabel	"vitamin D 25-hydroxylase"
GO:0030343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin D3 25-hydroxylase activity
GO:0030343	skos:altLabel	"CYP2R1"
GO:0030343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0030343	skos:altLabel	"vitamin D3 25-hydroxylase"
GO:0050322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurine--glutamate transaminase activity
GO:0050322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine-2-oxoglutarate transaminase activity
GO:0050322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine aminotransferase activity
GO:0050322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine transaminase activity
GO:0050322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurine--alpha-ketoglutarate aminotransferase activity
GO:0050322	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurine:2-oxoglutarate aminotransferase activity
GO:0004832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine-tRNA ligase activity
GO:0004832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-valine:tRNAVal ligase (AMP-forming)
GO:0004832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valyl-transfer RNA synthetase activity
GO:0004832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valyl-transfer ribonucleic acid synthetase activity
GO:0004832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine translase activity
GO:0004832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valyl-tRNA synthetase activity
GO:0004832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valyl-transfer ribonucleate synthetase activity
GO:0004832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine transfer ribonucleate ligase activity
REACT:R-SSC-8964599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Sus scrofa)
RHEA:43039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine <=> 2-aminoprop-2-enoate + H(+) + hydrogen sulfide
RHEA:34974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(3+)(in) <=> Fe(3+)(out)
RHEA:67712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)
REACT:R-DDI-163664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binds to gamma subunit of AMP kinase heterotrimer (Dictyostelium discoideum)
REACT:R-XTR-429955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR4-NOT complex deadenylates mRNA (Xenopus tropicalis)
RHEA:50763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + sulfite <=> a quinol + sulfate
GO:0070746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-35 binding
GO:0070746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-35 binding
REACT:R-BTA-2248891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARSA translocates to the lysosome (Bos taurus)
REACT:R-HSA-193407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
RHEA:14290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate + ATP + CoA => AMP + diphosphate + omega-dicarboxyl-CoA
RHEA:16712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan
REACT:R-GGA-353014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phosphoglycerate <=> 3-phosphoglycerate (Gallus gallus)
REACT:R-HSA-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Homo sapiens)
RHEA:40578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + H2O <=> CoA + glutarate + H(+)
RHEA:48712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O
REACT:R-HSA-1912378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sialylation of Pre-NOTCH (Homo sapiens)
REACT:R-HSA-109415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => adenosine + orthophosphate [NT5C1B] (Homo sapiens)
REACT:R-HSA-5260201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AKT2 phosphorylates C2CD5 (Homo sapiens)
REACT:R-HSA-9768142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3, IRF7 is transported to the nucleus (Homo sapiens)
RHEA:19028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate + O2 <=> H2O2 + NH4(+) + oxaloacetate
RHEA:61803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-alanine <=> AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]
REACT:R-CFA-1433454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GAB2 by SFKs (Canis familiaris)
REACT:R-MMU-3788075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by ADAMTS4, ADAMTS5 (Mus musculus)
GO:0052929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate
GO:0052929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity
GO:0052929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:3'-CC-tRNA adenylyltransferase activity
GO:0052929	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP:tRNA adenylyltransferase activity
REACT:R-RNO-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Rattus norvegicus)
RHEA:12884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + sn-glycerol 3-phosphate <=> 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)
RHEA:31778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate
REACT:R-HSA-9007522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds APAF1 gene promoter (Homo sapiens)
REACT:R-XTR-5696365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Xenopus tropicalis)
REACT:R-CFA-174587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Canis familiaris)
GO:0033819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity
GO:0033819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity
GO:0033819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity
GO:0033819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoyl (octanoyl)-acyl carrier protein:protein transferase activity
GO:0033819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoate/octanoate transferase activity
GO:0033819	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	octanoyl transferase activity (acting on glycine-cleavage complex H protein)
GO:0033819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanoyl-acyl carrier protein-protein N-octanoyltransferase activity
GO:0033819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoyl(octanoyl) transferase activity
REACT:R-DRE-5357845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is deubiquitinated (Danio rerio)
REACT:R-GGA-354149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
REACT:R-DRE-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Danio rerio)
RHEA:12672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate
REACT:R-DDI-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Dictyostelium discoideum)
REACT:R-SSC-140769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VII -> factor VIIa (Sus scrofa)
REACT:R-XTR-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Xenopus tropicalis)
RHEA:25724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:70156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5615604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective POMT1 does not transfer Man from Dol-P-Man to DAG1 (Homo sapiens)
REACT:R-PFA-111742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)
REACT:R-SSC-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Sus scrofa)
RHEA:56638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-XTR-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Xenopus tropicalis)
REACT:R-BTA-70859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Bos taurus)
REACT:R-SSC-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Sus scrofa)
REACT:R-CFA-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Canis familiaris)
RHEA:64999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + octanoate <=> diphosphate + octanoyl-AMP
REACT:R-HSA-167478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of HIV-1 early transcription elongation by DSIF:NELF (Homo sapiens)
RHEA:63909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + pravastatin(in) => ADP + H(+) + phosphate + pravastatin(out)
RHEA:47222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:72442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + ATP + H(+) <=> (E)-feruloyl-AMP + diphosphate
REACT:R-CFA-114684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Syntaxin-4 (Canis familiaris)
REACT:R-CEL-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Caenorhabditis elegans)
REACT:R-RNO-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Rattus norvegicus)
REACT:R-DME-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Drosophila melanogaster)
RHEA:57518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dolabradiene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Rattus norvegicus)
RHEA:40542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SPO-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Schizosaccharomyces pombe)
REACT:R-GGA-433815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viral dsRNA : TRL3 recruits TICAM1 (Gallus gallus)
RHEA:43338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out) => H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in)
REACT:R-CEL-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Caenorhabditis elegans)
REACT:R-HSA-9020256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Homo sapiens)
RHEA:39878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol
RHEA:71637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(out) + 2 thiosulfate(in) => phosphate(in) + 2 thiosulfate(out)
RHEA:29006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-homoserine(in) <=> H(+)(in) + L-homoserine(out)
REACT:R-HSA-9678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 binds S1PR1 agonists (Homo sapiens)
REACT:R-DRE-1855153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Danio rerio)
REACT:R-CEL-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Caenorhabditis elegans)
REACT:R-GGA-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Gallus gallus)
RHEA:40019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate
RHEA:12942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-CEL-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Caenorhabditis elegans)
REACT:R-CFA-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Canis familiaris)
REACT:R-CFA-5696872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates Ub-MOM proteins (Canis familiaris)
REACT:R-RNO-8986994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Rattus norvegicus)
REACT:R-RNO-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Rattus norvegicus)
GO:0047958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-glyoxylate transaminase activity
GO:0047958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic-glyoxylic transaminase activity
GO:0047958	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycine transaminase activity
GO:0047958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate-glutamate aminotransferase activity
GO:0047958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate:glyoxylate aminotransferase activity
GO:0047958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate-glutamic transaminase activity
GO:0047958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine:2-oxoglutarate aminotransferase activity
GO:0047958	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycine aminotransferase activity
RHEA:25979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:11512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicyl alcohol + UDP-alpha-D-glucose = H(+) + salicin + UDP
RHEA:11512	skos:prefLabel	"salicyl-alcohol beta-D-glucosyltransferase"
RHEA:11512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salicyl-alcohol beta-D-glucosyltransferase"
RHEA:69206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate
RHEA:29037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-glutamate(in) + phosphate => ATP + H2O + L-glutamate(out)
REACT:R-CFA-168921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIF:activated TLR3/TLR4 complex recruits RIP1 (Canis familiaris)
REACT:R-CEL-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Caenorhabditis elegans)
REACT:R-SSC-8862184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP48 cleaves polyubiquitin (Sus scrofa)
RHEA:22298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate + diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-CFA-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Canis familiaris)
RHEA:31760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine
EC:3.4.19.6	skos:altLabel	"TRH-degrading ectoenzyme"
EC:3.4.19.6	skos:altLabel	"thyroliberinase"
EC:3.4.19.6	skos:altLabel	"TRH-specific aminopeptidase"
EC:3.4.19.6	skos:altLabel	"pyroglutamyl aminopeptidase II"
EC:3.4.19.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyroglutamyl-peptidase II"
EC:3.4.19.6	skos:altLabel	"PAP-II"
EC:3.4.19.6	skos:prefLabel	"pyroglutamyl-peptidase II"
EC:3.4.19.6	skos:altLabel	"TRH-DE"
EC:3.4.19.6	skos:altLabel	"thyrotropin-releasing hormone degrading ectoenzyme"
RHEA:29212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + inosine(in) => H(+)(in) + inosine(out)
RHEA:11961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate
GO:0097244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol binding
REACT:R-HSA-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Homo sapiens)
GO:0061784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan N-acetylglucosaminidase activity
GO:0047766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-carbamoyl-L-serine deaminase activity
GO:0047766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoylserine deaminase activity
GO:0047766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)
GO:0047766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)
GO:0047766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl-serine ammonia-lyase activity
REACT:R-DDI-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Dictyostelium discoideum)
REACT:R-XTR-1678660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan sulfate chain(3) (Xenopus tropicalis)
REACT:R-CEL-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)
REACT:R-CEL-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Caenorhabditis elegans)
REACT:R-DDI-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Dictyostelium discoideum)
RHEA:34640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + neopentalenolactone D
REACT:R-MMU-166869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MEKK1 (Mus musculus)
REACT:R-RNO-5674130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Rattus norvegicus)
REACT:R-BTA-1369017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in muscle cells (Bos taurus)
REACT:R-HSA-109291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Homo sapiens)
RHEA:49670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyviolaceinate + H2O + NAD(+) => H(+) + NADH + O2 + protodeoxyviolaceinate
REACT:R-MMU-2130731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of COPII vesicle (Mus musculus)
REACT:R-HSA-5578742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO1,2:small RNA complexes interact with chromatin (Homo sapiens)
REACT:R-MMU-75083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Mus musculus)
REACT:R-DME-450257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
REACT:R-HSA-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Homo sapiens)
RHEA:49134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine
REACT:R-SSC-199206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Sus scrofa)
RHEA:20466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP
RHEA:23744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
RHEA:23744	skos:altLabel	"Histidinol-phosphate aminotransferase"
RHEA:23744	skos:altLabel	"imidazolylacetolphosphate aminotransferase"
RHEA:23744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histidinol-phosphate transaminase"
RHEA:23744	skos:altLabel	"Imidazole acetol-phosphate transaminase"
RHEA:23744	skos:prefLabel	"histidinol-phosphate transaminase"
RHEA:47786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine
RHEA:72098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine(out) + Na(+)(out) <=> (S)-carnitine(in) + Na(+)(in)
REACT:R-GGA-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Gallus gallus)
REACT:R-CFA-4827383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Canis familiaris)
REACT:R-RNO-174174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Rattus norvegicus)
REACT:R-SSC-9614564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO4 (Sus scrofa)
REACT:R-MMU-8851888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds SHC1-2 (Mus musculus)
RHEA:60265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:35858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-HSA-192065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
REACT:R-MMU-561072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal uptake of organic cations (Mus musculus)
RHEA:71846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tauroursodeoxycholate(out) <=> tauroursodeoxycholate(in)
RHEA:50869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrolipoyllysine-residue succinyltransferase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoic transsuccinylase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:dihydrolipoate S-succinyltransferase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrolipoamide S-succinyltransferase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoyl transsuccinylase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoate succinyltransferase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoyl transsuccinylase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoic transsuccinylase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:dihydrolipoamide S-succinyltransferase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipolyl transsuccinylase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoamide succinyltransferase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity
GO:0004149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoate succinyltransferase (Escherichia coli) activity
REACT:R-CFA-9724753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds anti-fibrinolytics (Canis familiaris)
REACT:R-MMU-5662692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is oxidized to dopaquinone by TYR (Mus musculus)
RHEA:29289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + L-aspartate(out) => 2 H(+)(in) + L-aspartate(in)
REACT:R-BTA-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Bos taurus)
RHEA:48954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH => 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+)
RHEA:47953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)
REACT:R-SSC-5618085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)
RHEA:38834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine
RHEA:62339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)
REACT:R-DDI-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Dictyostelium discoideum)
RHEA:14558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + raucaffricine => D-glucose + vomilenine
RHEA:51633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:29788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O => ADP + glutathione(out) + H(+) + phosphate
REACT:R-MMU-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Mus musculus)
REACT:R-BTA-445448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHIP binds Hedgehog (Bos taurus)
REACT:R-HSA-167474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive HIV-1 Initiation Before Second Transition (Homo sapiens)
REACT:R-HSA-5690023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL binds 4Fe-4S (Homo sapiens)
REACT:R-RNO-4088130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds FOXM1 (Rattus norvegicus)
RHEA:72403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + urate(in) = 2-oxoglutarate(in) + urate(out)
REACT:R-CFA-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Canis familiaris)
RHEA:26012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)
RHEA:13604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-hydroxy-L-proline + NAD(+) <=> 4-oxo-L-proline + H(+) + NADH
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylcarnitine transferase activity
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine palmitoyltransferase I
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPT
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPTo
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoylcarnitine transferase activity
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine O-palmitoyltransferase activity
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine palmitoyltransferase-A
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPT-B
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPT I (outer membrane carnitine palmitoyl transferase)
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine palmitoyltransferase II
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-carnitine palmitoyltransferase activity
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPTi
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPT-A
GO:0004095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine palmitoyltransferase activity
REACT:R-CFA-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Canis familiaris)
REACT:R-RNO-190429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c (Rattus norvegicus)
GO:0047169	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galacturate hydroxycinnamoyltransferase activity
GO:0047169	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity
GO:0047169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate O-hydroxycinnamoyltransferase activity
GO:0047169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + galactarate = 2-O-[(E)-feruloyl]-D-galactarate + CoA
GO:0047169	skos:prefLabel	"galactarate O-hydroxycinnamoyltransferase"
GO:0047169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactarate O-hydroxycinnamoyltransferase"
REACT:R-PFA-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Plasmodium falciparum)
RHEA:35916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-HSA-8943080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 (Homo sapiens)
RHEA:12999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-[(E)-feruloyl]-D-galactarate + CoA => (E)-feruloyl-CoA + galactarate
REACT:R-DRE-170072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Danio rerio)
RHEA:69022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hydroxy-L-aspartate + NADP(+) => L-aspartate + NADPH + O2
RHEA:36787	skos:prefLabel	"UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase"
RHEA:36787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
RHEA:36787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase"
RHEA:16837	skos:prefLabel	"5'-acylphosphoadenosine hydrolase"
RHEA:16837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-acylphosphoadenosine + H2O = a carboxylate + AMP + 2 H(+)
RHEA:16837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5'-acylphosphoadenosine hydrolase"
RHEA:49327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R,6S)-5,6-epoxi-capsanthin <=> all-trans-capsorubin
RHEA:24067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5-aminolevulinate <=> H(+) + 2 H2O + porphobilinogen
REACT:R-HSA-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Homo sapiens)
RHEA:65320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chrodrimanin E + O2 = chrodrimanin A + CO2 + succinate
RHEA:46538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-MMU-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Mus musculus)
RHEA:62651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate
RHEA:34805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisdemethoxycurcumin + 2 CO2 + 3 CoA => 2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA
REACT:R-DRE-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Danio rerio)
REACT:R-CEL-8956639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds YAP1 (Caenorhabditis elegans)
REACT:R-SSC-190682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin synthesis (generic) (Sus scrofa)
GO:0004666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acid cyclooxygenase activity
GO:0004666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(PG)H synthase activity
GO:0004666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PG synthetase activity
GO:0004666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity
GO:0004666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin-endoperoxide synthase activity
GO:0004666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin synthase activity
GO:0004666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin synthetase activity
GO:0004666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin G/H synthase activity
GO:0004666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS1 (Homo sapiens)
GO:0004666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin endoperoxide synthetase activity
REACT:R-CFA-5660660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p300 acetylates RELA subunit (Canis familiaris)
RHEA:60439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutyl acetate + H2O <=> 3-methylbutanol + acetate + H(+)
REACT:R-RNO-9008054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RAPL1 (Rattus norvegicus)
RHEA:19149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
RHEA:53344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20a) in tRNA + NADP(+) = H(+) + NADPH + uridine(20a) in tRNA
REACT:R-RNO-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Rattus norvegicus)
RHEA:55834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:69949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-6797961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHDH oxidises Cho to BETALD (Sus scrofa)
REACT:R-SSC-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)
REACT:R-MMU-450474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates BRF1 (Mus musculus)
RHEA:20048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H2O + NAD(+) <=> 2 H(+) + malonate + NADH
RHEA:13378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + ATP => ADP + alpha-D-glucose 1,6-bisphosphate + H(+)
REACT:R-DDI-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Dictyostelium discoideum)
REACT:R-CEL-8878581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYRP1 oxidises DHICA to IQCA (Caenorhabditis elegans)
RHEA:43548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
REACT:R-HSA-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Homo sapiens)
RHEA:12147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-rutinoside + UDP-alpha-D-glucose <=> cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP
RHEA:14212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-galactose
REACT:R-CFA-8956026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL9:RBX1 ubiquitinates BIRC5 (Canis familiaris)
REACT:R-HSA-9683606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein translocates to the nucleolus (Homo sapiens)
REACT:R-MMU-1504193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL is degraded by the proteasome (Mus musculus)
REACT:R-MMU-8964317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)
RHEA:15831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16beta-hydroxysteroid => a 16alpha-hydroxysteroid
GO:0070038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (pseudouridine-N3-)-methyltransferase activity
REACT:R-CEL-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Caenorhabditis elegans)
RHEA:26243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + elisabethatriene => geranylgeranyl diphosphate
RHEA:69126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + indole-3-pyruvate => glyoxylate + L-tryptophan
REACT:R-DRE-9018858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Danio rerio)
RHEA:60825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate => 2 AMP + 2 H(+)
REACT:R-SSC-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Sus scrofa)
GO:0043915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-tRNA(Sec) kinase activity
GO:0043915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-phosphoseryl-tRNA(Sec) kinase activity
REACT:R-BTA-8871376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds PI3P (Bos taurus)
RHEA:34938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate
RHEA:43872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oate + ATP + CoA = 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate
GO:0103096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP79F1 dihomomethionine monooxygenase activity
REACT:R-DRE-2213200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of endostatin-like peptides (Danio rerio)
RHEA:35343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydocosanoyl-CoA + NADP(+) = 3-oxodocosanoyl-CoA + H(+) + NADPH
RHEA:20593	skos:prefLabel	"N-acetylglucosamine deacetylase"
RHEA:20593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosamine deacetylase"
RHEA:20593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamine = acetate + D-glucosamine
REACT:R-SSC-5692779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S182 MAPKAPK5 phosphorylates FOXO1 (Sus scrofa)
REACT:R-BTA-174690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Bos taurus)
REACT:R-CFA-5668417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)
REACT:R-MMU-6814670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Mus musculus)
RHEA:13073	skos:prefLabel	"guanosine-5'-triphosphate,3'-diphosphate diphosphatase"
RHEA:13073	skos:altLabel	"guanosine pentaphosphate phosphohydrolase"
RHEA:13073	skos:altLabel	"guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase"
RHEA:13073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate
RHEA:13073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanosine-5'-triphosphate,3'-diphosphate diphosphatase"
RHEA:13073	skos:altLabel	"pppGpp 5'-phosphohydrolase"
REACT:R-BTA-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Bos taurus)
RHEA:21754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-capsorubin => all-trans-violaxanthin
REACT:R-BTA-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Bos taurus)
REACT:R-HSA-3965447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)
REACT:R-MMU-158800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Mus musculus)
REACT:R-RNO-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Rattus norvegicus)
REACT:R-SSC-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Sus scrofa)
GO:0140233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential
GO:0140233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential
RHEA:27877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochorismate <=> pyruvate + salicylate
REACT:R-CFA-4641206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPOs bind LGRs (Canis familiaris)
REACT:R-RNO-8940100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates VCPIP1 (Rattus norvegicus)
RHEA:56358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dibromophenol + CO2 + 2 H2O + NADP(+) => 3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2
REACT:R-CFA-5628871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 promotes EP300-mediated acetylation of TP53 (Canis familiaris)
REACT:R-DRE-5422942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXRA:PPARD binds FABP5:atRA (Danio rerio)
REACT:R-SSC-9759206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Sus scrofa)
REACT:R-BTA-202241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SLP-76 to Gads (Bos taurus)
REACT:R-HSA-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Homo sapiens)
REACT:R-GGA-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Gallus gallus)
REACT:R-RNO-8948709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Rattus norvegicus)
GO:0047289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosyldiacylglycerol alpha-2,3-sialyltransferase activity
GO:0047289	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase activity
REACT:R-RNO-982775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor dimerizes (Rattus norvegicus)
RHEA:34950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-aminoacrylate + H(+) + H2O <=> 3-oxopropanoate + NH4(+)
RHEA:59488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:39209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexacosanoyl-CoA + NADP(+) => 3-oxohexacosanoyl-CoA + H(+) + NADPH
RHEA:61550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-1297338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of ADAM and B4GALT1 With ZP3 (Homo sapiens)
RHEA:45529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
GO:0070538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleic acid binding
REACT:R-XTR-351863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active caspase-8 to the mitochondrial membrane (Xenopus tropicalis)
RHEA:11117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an alkane-alpha,omega-diamine => an N-acetylalkane-alpha,omega-diamine + CoA + H(+)
RHEA:20934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + formaldehyde => L-erythrulose 1-phosphate
GO:1901640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XTP binding
RHEA:17450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + flaviolin => 3-linalylflaviolin + diphosphate
REACT:R-BTA-158860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates NHABP (Bos taurus)
REACT:R-SSC-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Sus scrofa)
RHEA:21559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[calmodulin]-L-lysine + S-adenosyl-L-methionine <=> [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Gallus gallus)
REACT:R-RNO-6799959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP3,4 binds bacterial peptidoglycan (Rattus norvegicus)
REACT:R-CFA-373748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD72 (Canis familiaris)
RHEA:64826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthaleneacetate + NH4(+) => 1-naphthaleneacetamide + H2O
REACT:R-HSA-174367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCL ligates L-Glu to L-Cys (Homo sapiens)
EC:3.2.2.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrimidine-5'-nucleotide nucleosidase"
EC:3.2.2.10	skos:prefLabel	"pyrimidine-5'-nucleotide nucleosidase"
EC:3.2.2.10	skos:altLabel	"Pyr5N"
REACT:R-CFA-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Canis familiaris)
REACT:R-XTR-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Xenopus tropicalis)
RHEA:27608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine
REACT:R-SPO-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)
REACT:R-SSC-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Sus scrofa)
REACT:R-SSC-8854052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the SCF-FBXL7 complex (Sus scrofa)
REACT:R-HSA-8983845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dissociates from IL6ST:IL6ST (Homo sapiens)
RHEA:29867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ITP = ADP + IDP
REACT:R-HSA-2161999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)
REACT:R-CEL-194121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:66097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine
REACT:R-MMU-202443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of CARMA1 (Mus musculus)
REACT:R-MMU-1358791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of USP8 by P-AKT (Mus musculus)
RHEA:50049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholate(in) + H2O => ADP + cholate(out) + H(+) + phosphate
RHEA:47887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
REACT:R-BTA-203567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylation of eNOS (Bos taurus)
REACT:R-BTA-9731931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds selective ERAs (Bos taurus)
RHEA:20362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:23133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] => 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite
REACT:R-DDI-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Dictyostelium discoideum)
REACT:R-MMU-389481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 1 receptor can bind orexin-A neuropeptide (Mus musculus)
GO:0008835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity
GO:0008835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity
GO:0008835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
GO:0008835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity
REACT:R-BTA-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Bos taurus)
REACT:R-MMU-3878123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of SAHF formation (Mus musculus)
GO:0015552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionate transmembrane transporter activity
GO:0016856	skos:prefLabel	"Acting on hydroxy acids and derivatives"
GO:0016856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on hydroxy acids and derivatives"
GO:0016856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	racemase and epimerase activity, acting on hydroxy acids and derivatives
REACT:R-HSA-4167501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An unknown protease degrades ACACB (Homo sapiens)
GO:0033937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	octulofuranosylono hydrolase activity
GO:0033937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	octulopyranosylonohydrolase activity
GO:0033937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity
GO:0033937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	octulosylono hydrolase activity
GO:0033937	skos:prefLabel	"3-deoxy-2-octulosonidase"
GO:0033937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-2-octulosonidase activity
GO:0033937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-2-octulosonidase"
GO:0033937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxyoctonate hydrolase activity
RHEA:51183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
RHEA:23992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA
RHEA:23992	skos:prefLabel	"1-alkylglycerophosphocholine O-acyltransferase"
RHEA:23992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-alkylglycerophosphocholine O-acyltransferase"
REACT:R-HSA-4570493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)
REACT:R-SCE-1855205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Saccharomyces cerevisiae)
REACT:R-HSA-166721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
REACT:R-SSC-2473584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP15 (Sus scrofa)
REACT:R-CFA-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Canis familiaris)
REACT:R-CEL-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Caenorhabditis elegans)
REACT:R-HSA-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Homo sapiens)
RHEA:51417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH
REACT:R-DRE-169895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk's SH3 domain engages C3G (Danio rerio)
RHEA:61401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-ribulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine
RHEA:29612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nitrous oxide => H(+) + NADPH + 2 nitric oxide
REACT:R-HSA-2176491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)
REACT:R-MMU-9009817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acitretin binds to RAR:RXR (Mus musculus)
REACT:R-XTR-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Xenopus tropicalis)
REACT:R-RNO-203973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle budding (Rattus norvegicus)
REACT:R-HSA-158860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates NHABP (Homo sapiens)
REACT:R-BTA-9627089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP9 is phosphorylated at T125 (Bos taurus)
REACT:R-CFA-1604712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP7 by trypsin (Canis familiaris)
RHEA:23134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite => 3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Danio rerio)
REACT:R-MMU-5696007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF3 ligates CoA-SH to VLCFA (Mus musculus)
GO:0043774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420-2 alpha-glutamyl ligase activity
GO:0043774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-2 alpha-glutamyl ligase activity
REACT:R-MMU-1482546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by CRLS1 (IM) (Mus musculus)
REACT:R-DRE-6799495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYCTK phosphorylates DGA to 3PDGA (Danio rerio)
RHEA:32414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,4S)-isodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH
REACT:R-XTR-3266557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I cleaves iC3b (Xenopus tropicalis)
RHEA:21392	skos:prefLabel	"phenylacetaldehyde dehydrogenase"
RHEA:21392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetaldehyde dehydrogenase"
RHEA:21392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + H2O + NAD(+) = 2-phenylacetate + 2 H(+) + NADH
RHEA:25316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => L-2-acetamido-6-oxoheptanedioate + L-glutamate
REACT:R-DRE-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Danio rerio)
REACT:R-XTR-201422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Xenopus tropicalis)
RHEA:61837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol + UDP-alpha-D-glucose => ergosteryl 3-beta-D-glucoside + H(+) + UDP
RHEA:31633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + pseudaminate => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate
REACT:R-RNO-4608855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRICKLE1 is degraded by the proteasome (Rattus norvegicus)
RHEA:70815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-histidine(in) + L-ornithine(out) = H(+)(out) + L-histidine(out) + L-ornithine(in)
REACT:R-SSC-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Sus scrofa)
REACT:R-CFA-5358599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Canis familiaris)
RHEA:52320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tryptamine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin
REACT:R-RNO-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Rattus norvegicus)
GO:0042010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-15 receptor activity
GO:0042010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-15R
GO:0042010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-15 receptor activity
REACT:R-BTA-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Bos taurus)
REACT:R-DME-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Drosophila melanogaster)
REACT:R-BTA-9647645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD oligomerizes into arc-, slit-shaped structures (Bos taurus)
REACT:R-XTR-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Xenopus tropicalis)
REACT:R-RNO-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Rattus norvegicus)
GO:0019112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrol glycosyltransferase activity
REACT:R-SPO-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)
RHEA:32026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> avermitilol + diphosphate
RHEA:36383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl adenylate + tobramycin = AMP + H(+) + nebramycin 5'
REACT:R-CFA-5665767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FMNL3 binds G-actin (Canis familiaris)
REACT:R-CEL-879594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO4C1 mediates the transport of digoxin (Caenorhabditis elegans)
RHEA:37874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 <=> 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)
REACT:R-SSC-5694082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XK:KEL:Zn2+ cleaves EDN3 (Sus scrofa)
REACT:R-DME-4641256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated AXIN is degraded by the proteasome (Drosophila melanogaster)
RHEA:37739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA
RHEA:36527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA = (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA
RHEA:10632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NAD(+) = D-mannuronate + H(+) + NADH
RHEA:40230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + desulfo-A47934 <=> A47934 + adenosine 3',5'-bisphosphate + H(+)
RHEA:42639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-cysteine + Mo-molybdopterin <=> A + H2O + L-alanine + thio-Mo-molybdopterin
GO:0102611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-secoisolariciresinol monoglucoside glucosyltransferase activity
REACT:R-XTR-140847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Xenopus tropicalis)
RHEA:59221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)
REACT:R-XTR-3204311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOX1 oxidises PXL to PDXate (Xenopus tropicalis)
REACT:R-RNO-391211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trace amine-associated receptors can bind trace amines (Rattus norvegicus)
REACT:R-MMU-165692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)
REACT:R-DME-4093336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
REACT:R-CFA-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
REACT:R-MMU-114670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binds to vWF:Collagen complex (Mus musculus)
REACT:R-HSA-5660965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCL17 and CCL22 genes are transcribed (Homo sapiens)
REACT:R-MMU-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Mus musculus)
RHEA:59702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellopentaonate + H(+) => D-cellopentaono-1,5-lactone + H2O
RHEA:37084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine => [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine
RHEA:54542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]
RHEA:57080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + S-methyl-1-thio-D-xylulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione
REACT:R-RNO-6809663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hair keratin fibres (Rattus norvegicus)
REACT:R-HSA-449058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family are secreted (Homo sapiens)
REACT:R-HSA-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Homo sapiens)
RHEA:70057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-methoxybenzoate + A + N2 => AH2 + cremeomycin
RHEA:22460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + NADP(+) = a 2,3-dehydroacyl-CoA + H(+) + NADPH
RHEA:22460	skos:altLabel	"enoyl coenzyme A reductase"
RHEA:22460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA dehydrogenase (NADP(+))"
RHEA:22460	skos:altLabel	"2-enoyl-CoA reductase"
RHEA:22460	skos:prefLabel	"acyl-CoA dehydrogenase (NADP(+))"
RHEA:71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(out) + succinate(in) <=> malonate(in) + succinate(out)
GO:0004997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyrotropin-releasing hormone receptor activity
RHEA:53404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-HSA-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Homo sapiens)
REACT:R-HSA-420584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin 3 trans heterodimer interaction (Homo sapiens)
RHEA:36847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FAD:protein FMN transferase"
RHEA:36847	skos:altLabel	"flavin transferase"
RHEA:36847	skos:prefLabel	"FAD:protein FMN transferase"
RHEA:36847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)
RHEA:57888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
RHEA:70343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + L-tyrosine + NADP(+) = 3-chloro-L-tyrosine + NADPH
RHEA:52689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH
GO:0047652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	allantoate amidohydrolase activity
GO:0047652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate deiminase activity
GO:0047652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + 2 H(+) + H2O = (S)-2-ureidoglycine + CO2 + NH4(+)
GO:0047652	skos:prefLabel	"allantoate deiminase"
GO:0047652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"allantoate deiminase"
GO:0047652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	allantoate amidinohydrolase (decarboxylating)
REACT:R-RNO-168440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Rattus norvegicus)
REACT:R-RNO-5654684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR4 (Rattus norvegicus)
REACT:R-RNO-158766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Rattus norvegicus)
REACT:R-RNO-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Rattus norvegicus)
REACT:R-SSC-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Sus scrofa)
RHEA:23972	skos:altLabel	"4-carboxybut-2-enoyl-CoA carboxy-lyase"
RHEA:23972	skos:prefLabel	"glutaconyl-CoA decarboxylase"
RHEA:23972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-glutaconyl-CoA + H(+) + Na(+)(in) = (2E)-butenoyl-CoA + CO2 + Na(+)(out)
RHEA:23972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutaconyl-CoA decarboxylase"
RHEA:23972	skos:altLabel	"glutaconyl coenzyme A decarboxylase"
RHEA:23972	skos:altLabel	"pent-2-enoyl-CoA carboxy-lyase"
RHEA:16845	skos:altLabel	"(R)-citrate synthase"
RHEA:16845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)
RHEA:16845	skos:altLabel	"citrate oxaloacetate-lyase [(pro-3S)-CH2COO->acetyl-CoA]"
RHEA:16845	skos:prefLabel	"citrate (Si)-synthase"
RHEA:16845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citrate (Si)-synthase"
REACT:R-BTA-1475028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Bos taurus)
REACT:R-MMU-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Mus musculus)
REACT:R-HSA-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Homo sapiens)
RHEA:59192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + eicosanoate + H(+) = diphosphate + icosanoyl-AMP
REACT:R-HSA-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
RHEA:35783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neamine + UDP-alpha-D-kanosamine = H(+) + kanamycin B + UDP
RHEA:58222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide => L-lysyl-[protein] + NAD(+)
GO:0102964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity
REACT:R-HSA-77299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Homo sapiens)
RHEA:35417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP => an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose
RHEA:25466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + longifolene => (2E,6E)-farnesyl diphosphate
RHEA:60560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionyl-[protein] + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]
RHEA:12106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydrofolate + dTMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP
REACT:R-SSC-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Sus scrofa)
REACT:R-HSA-8878266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IHH gene transcription is stimulated by RUNX2 (Homo sapiens)
RHEA:20531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisate + H(+) + H2O2 => 2-cis-(+)-abscisic aldehyde + H2O + O2
REACT:R-BTA-6786239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
RHEA:65428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deamido-NAD(+)(in) + NAD(+)(out) = deamido-NAD(+)(out) + NAD(+)(in)
REACT:R-MMU-8862090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Mus musculus)
RHEA:12828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine <=> [thioredoxin]-dithiol + H(+) + phosphate + sarcosine
RHEA:25249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2
REACT:R-MMU-9707586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM oxidises LDL,HDL (Mus musculus)
RHEA:69089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + H2O + NAD(+) => butanoate + 2 H(+) + NADH
REACT:R-HSA-9698754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 binds the NOX4 promoter (Homo sapiens)
REACT:R-DME-9634850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT (Drosophila melanogaster)
REACT:R-RNO-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)
REACT:R-XTR-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Xenopus tropicalis)
REACT:R-HSA-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Homo sapiens)
REACT:R-BTA-8985343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SOX9 (Bos taurus)
REACT:R-BTA-9699578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 phosphorylates CDKN1B (Bos taurus)
RHEA:35334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH
REACT:R-SSC-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Sus scrofa)
RHEA:37989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-phytyl-1,4-benzene-1,4-diol => delta-tocopherol
REACT:R-CFA-1793186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Canis familiaris)
RHEA:55014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + NADPH + O2
REACT:R-DME-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Drosophila melanogaster)
REACT:R-DRE-9021079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs:CAVs translocate to plasma membrane (Danio rerio)
RHEA:30539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinyl-CoA = (S)-carnitinyl-CoA
REACT:R-SSC-373073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR1, 2 and 8 bind CCL16 ligand (Sus scrofa)
REACT:R-BTA-2454081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5 oxidises 11cROL to 11cRAL (Bos taurus)
RHEA:11683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + XMP <=> AMP + diphosphate + GMP + 2 H(+) + L-glutamate
RHEA:51510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + succinate + trans-4-hydroxy-L-proline => 2-oxoglutarate + L-proline + O2
REACT:R-SSC-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Sus scrofa)
RHEA:54329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-[ACP] + 2 NADPH => hexadecan-1-ol + holo-[ACP] + 2 NADP(+)
RHEA:72934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] <=> atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:43903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)
REACT:R-DDI-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Dictyostelium discoideum)
REACT:R-DME-9635739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)
REACT:R-SCE-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Saccharomyces cerevisiae)
REACT:R-CEL-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
REACT:R-DME-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Drosophila melanogaster)
RHEA:65147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + berkeleyone A + O2 <=> CO2 + H2O + preaustinoid A + succinate
REACT:R-DRE-4755419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1H4 with SUMO1 (Danio rerio)
RHEA:24028	skos:altLabel	"gamma-BBH"
RHEA:24028	skos:altLabel	"gamma-butyrobetaine,2-oxoglutarate dioxygenase"
RHEA:24028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate
RHEA:24028	skos:altLabel	"gamma-butyrobetaine hydroxylase"
RHEA:24028	skos:prefLabel	"gamma-butyrobetaine dioxygenase"
RHEA:24028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-butyrobetaine dioxygenase"
REACT:R-DME-209167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated REL is cleaved by and dissociates from DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)
REACT:R-RNO-2314678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS1 (Rattus norvegicus)
RHEA:40707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-MMU-8938121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds CTSK (Mus musculus)
REACT:R-DRE-5687120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Danio rerio)
REACT:R-DRE-379426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Danio rerio)
REACT:R-HSA-9766532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomer is phosphorylated (Homo sapiens)
RHEA:33600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine
GO:0060703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonuclease inhibitor activity
GO:0060703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNase inhibitor activity
REACT:R-CEL-389639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Caenorhabditis elegans)
REACT:R-PFA-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Plasmodium falciparum)
GO:0102211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"unsaturated rhamnogalacturonyl hydrolase"
GO:0102211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	unsaturated rhamnogalacturonyl hydrolase activity
GO:0102211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose
GO:0102211	skos:prefLabel	"unsaturated rhamnogalacturonyl hydrolase"
REACT:R-PFA-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)
RHEA:26209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine = acetaldehyde + glycine
RHEA:30058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine + NADP(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADPH
REACT:R-HSA-420582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin-1 trans heterodimer interaction (Homo sapiens)
REACT:R-DME-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Drosophila melanogaster)
RHEA:11091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trimetaphosphate <=> 2 H(+) + triphosphate
RHEA:59964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-seryl-[protein]
RHEA:55729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate
RHEA:39711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)
RHEA:39711	skos:prefLabel	"coenzyme F420H2 oxidase"
RHEA:39711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coenzyme F420H2 oxidase"
REACT:R-BTA-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Bos taurus)
GO:0097627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity L-ornithine transmembrane transporter activity
GO:0097627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity L-ornithine transmembrane transporter activity
REACT:R-DME-8964634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Drosophila melanogaster)
REACT:R-SSC-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Sus scrofa)
RHEA:12315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)
RHEA:29519	skos:altLabel	"GDP-Man:Man2GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase"
RHEA:29519	skos:prefLabel	"GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase"
RHEA:29519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase"
RHEA:29519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)
REACT:R-SCE-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Saccharomyces cerevisiae)
REACT:R-SPO-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Schizosaccharomyces pombe)
REACT:R-GGA-5223305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL, inhibiting it (Gallus gallus)
REACT:R-XTR-1912372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fringe-modified Pre-NOTCH is cleaved by FURIN (Xenopus tropicalis)
RHEA:52312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + thromboxane B2 = 11-dehydro-thromboxane B2 + H(+) + NADH
RHEA:45277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-phosphooxy-(9E)-octadecenoate + H2O => 12-hydroxy-(9E)-octadecenoate + phosphate
REACT:R-HSA-2408543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeCysta is hydrolysed to Sec by PXLP-K212-CTH (Homo sapiens)
REACT:R-MMU-443774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homodimerization of Neurofascin (Mus musculus)
RHEA:24946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) <=> (4S)-4-hydroxy-L-glutamate + H(+) + NADPH
RHEA:55186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylundecanoyl-CoA + O2
GO:0004166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity
GO:0004166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl phosphate acetylglucosaminyltransferase activity
GO:0004166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity
GO:0004166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-phosphate N-acetylglucosaminyltransferase activity
GO:0004166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity
GO:0004166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-phosphate acetylglucosaminyltransferase activity
GO:0004166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity
GO:0004166	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl phosphate N-acetylglucosaminyltransferase activity
REACT:R-SCE-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Saccharomyces cerevisiae)
RHEA:43139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine
RHEA:47392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoate ester = an aliphatic alcohol + H(+) + hexadecanoate
REACT:R-DME-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Drosophila melanogaster)
REACT:R-XTR-2167942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII ectodomain shedding (Xenopus tropicalis)
REACT:R-MMU-6809521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPIF binds bacteria (Mus musculus)
RHEA:21069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + nitrite => AH2 + nitrate
REACT:R-DME-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Drosophila melanogaster)
REACT:R-RNO-77321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Rattus norvegicus)
RHEA:53264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-114263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization  of BAK at the mitochondrial membrane (Canis familiaris)
REACT:R-CEL-3858495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits GTP-bound RHOA (Caenorhabditis elegans)
REACT:R-HSA-392835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 sequesters Raf1 to inhibit ERK cascade (Homo sapiens)
RHEA:36401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + zymosterol => 5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-DRE-69600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic degradation of ubiquitinated-Cdc25A (Danio rerio)
REACT:R-MMU-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Mus musculus)
RHEA:69726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-AMP + CoA <=> (indol-3-yl)acetyl-CoA + AMP + H(+)
RHEA:66412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)
REACT:R-HSA-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Homo sapiens)
REACT:R-XTR-190427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1b (Xenopus tropicalis)
REACT:R-CFA-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Canis familiaris)
REACT:R-SSC-5655466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Sus scrofa)
RHEA:65711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-mannose
RHEA:36477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA
RHEA:68983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tauroursodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH
REACT:R-MMU-202245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TBSMs in LAT (Mus musculus)
REACT:R-BTA-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Bos taurus)
REACT:R-MMU-4411402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NLK (Mus musculus)
RHEA:45055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + (R)-carnitine <=> CoA + O-(2E)-butenoyl-(R)-carnitine
REACT:R-RNO-190388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3c (Rattus norvegicus)
RHEA:71366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) <=> 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)
RHEA:35692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-versicolorone + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH
REACT:R-BTA-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Bos taurus)
REACT:R-HSA-2870221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-selectin binds E-selectin ligand (Homo sapiens)
REACT:R-SSC-9688832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PDCD6IP and SDCBP (Sus scrofa)
RHEA:42648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2,5-ethylene furandicarboxylate)(n) + 2 H2O = (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)
REACT:R-XTR-8851988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A2 binds T cell surface (Xenopus tropicalis)
RHEA:49625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + erythritol => ADP + D-erythritol 1-phosphate + H(+)
RHEA:60456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UTP = 3',3'-cUAMP + 2 diphosphate
RHEA:54199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
GO:0008678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-gluconate 3-dehydrogenase activity
GO:0008678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity
GO:0008678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygluconate oxidoreductase activity
GO:0008678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-deoxygluconate dehydrogenase activity
REACT:R-HSA-5225649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP7 binds histone H3 (Homo sapiens)
REACT:R-SSC-917693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESCRT Disassembly (Sus scrofa)
REACT:R-RNO-5682084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Rattus norvegicus)
RHEA:12655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADH + pyruvate => (S)-malate + NAD(+)
REACT:R-HSA-349593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with Fibronectin (Homo sapiens)
RHEA:47084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-methionine
RHEA:48190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:31519	skos:prefLabel	"torulene dioxygenase"
RHEA:31519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"torulene dioxygenase"
RHEA:31519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + torulene = 3-methyl-2-butenal + 4'-apo-beta-carotenal
RHEA:21050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate => ATP + isopropylamine + L-glutamate
REACT:R-SSC-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Sus scrofa)
REACT:R-HSA-198211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active TRKA binds IRS1/2 (Homo sapiens)
RHEA:68999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A9 + O2 <=> CO2 + gibberellin A4 + succinate
REACT:R-HSA-9614271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ADGRG6 (Homo sapiens)
REACT:R-GGA-380316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of NuMA with microtubules (Gallus gallus)
REACT:R-DRE-74207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Danio rerio)
REACT:R-DME-9009309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STUB1 (Drosophila melanogaster)
REACT:R-XTR-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Xenopus tropicalis)
RHEA:66790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-L-dopa + O2
REACT:R-SSC-3322429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP monoubiquinates TLE (Sus scrofa)
RHEA:21382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + ATP + CoA
REACT:R-GGA-2168881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Truncated Alpha-1-Microglobulin binds heme (Gallus gallus)
REACT:R-DME-176116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of Chk1 (Drosophila melanogaster)
RHEA:55597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine => globoside NORint + H(+) + UDP
RHEA:36189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine
REACT:R-XTR-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Xenopus tropicalis)
REACT:R-GGA-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Gallus gallus)
RHEA:24578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 phosphate => diphosphate + H2O
REACT:R-CEL-3149519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC decyanates CNCbl (Caenorhabditis elegans)
REACT:R-GGA-141409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mad1 binds kinetochore (Gallus gallus)
RHEA:51846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-glycanase activity
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycopeptidase activity
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-oligosaccharide glycopeptidase activity
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNGase
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide:N-glycanase
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycopeptide N-glycosidase activity
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PNGase F
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PNGase A
GO:0000224	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	jack-bean glycopeptidase
REACT:R-XTR-202724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-selectin binds P-selectin ligand (Xenopus tropicalis)
REACT:R-GGA-4641134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds AXIN (Gallus gallus)
RHEA:46915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juvenile hormone III <=> H(+) + juvenile hormone III carboxylate + methanol
RHEA:47198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-DRE-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)
REACT:R-HSA-173545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Homo sapiens)
REACT:R-MMU-9654533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B recycles to the plasma membrane (Mus musculus)
REACT:R-BTA-6810472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT13 hydrolyses AP6A to AP4 and ADP (Bos taurus)
RHEA:24241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + AMP + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + AH2
RHEA:42047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) <=> GDP + globoside Globo-H (d18:1(4E)) + H(+)
REACT:R-HSA-2309787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS2 (Homo sapiens)
GO:0102190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity
RHEA:71319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-cysteine(out) + 2 Na(+)(out) = chloride(in) + L-cysteine(in) + 2 Na(+)(in)
REACT:R-HSA-5339711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling (Homo sapiens)
REACT:R-BTA-432952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP180 interacts intracellularly with plectin and integrin beta4 (Bos taurus)
REACT:R-HSA-2038386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of FGFR3 t(4;14) translocation mutants (Homo sapiens)
REACT:R-CEL-71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Caenorhabditis elegans)
RHEA:16142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + NAD(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADH
REACT:R-MMU-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Mus musculus)
REACT:R-HSA-4086392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Homo sapiens)
REACT:R-DRE-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Danio rerio)
REACT:R-SSC-75825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of Cyclin D1 (Sus scrofa)
RHEA:24162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galacto-hexodialdose + H2O2 => D-galactose + O2
RHEA:47987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + presqualene diphosphate <=> diphosphate + hydroxysqualene
REACT:R-HSA-110238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPG glycosylase mediated recognition and binding of 3-methyladenine  (Homo sapiens)
REACT:R-CFA-8856630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIDEA:CIDEC binds lipid droplets (Canis familiaris)
EC:2.4.1.78	skos:prefLabel	"phosphopolyprenol glucosyltransferase"
EC:2.4.1.78	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphopolyprenol glucosyltransferase"
RHEA:63482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin F2alpha + H(+) + NADPH => NADP(+) + prostaglandin F2alpha
REACT:R-DDI-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)
GO:0009678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen-translocating pyrophosphatase activity
GO:0009678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proton-pumping diphosphatase
GO:0009678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proton-pumping pyrophosphatase
GO:0009678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate hydrolysis-driven proton transmembrane transporter activity
GO:0009678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H+-exporting diphosphatase
GO:0009678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP(i) hydrolysis-driven proton transmembrane transporter activity
GO:0009678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate hydrolysis-driven proton transmembrane transporter activity
GO:0009678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton-translocating pyrophosphatase activity
REACT:R-CFA-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Canis familiaris)
REACT:R-RNO-9025152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Rattus norvegicus)
GO:0045552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroflavonol 4-reductase activity
GO:0045552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity
GO:0045552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroquercetin reductase activity
GO:0045552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroflavanol 4-reductase activity
GO:0045552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dihydromyricetin reductase activity
GO:0045552	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydromyricetin reductase activity
GO:0045552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrokaempferol 4-reductase activity
GO:0051034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA transmembrane transporter activity
REACT:R-SSC-2066779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Sus scrofa)
GO:0043924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Germanin binding
GO:0043924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	suramin binding
REACT:R-MMU-430158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds VAV (Mus musculus)
REACT:R-XTR-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Xenopus tropicalis)
REACT:R-BTA-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)
RHEA:66688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 = (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O
REACT:R-CEL-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Caenorhabditis elegans)
RHEA:37788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Homo sapiens)
REACT:R-CFA-1861595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extension of pseudopodia by myosin-X in a PI3K dependent manner (Canis familiaris)
REACT:R-SCE-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Saccharomyces cerevisiae)
REACT:R-HSA-8943780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 recruits NuRD to PTEN gene (Homo sapiens)
RHEA:66993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylpentanoate + ATP + CoA => 3-methylpentanoyl-CoA + AMP + diphosphate
GO:0072354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H3-T3 specific)
GO:0072354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone threonine kinase activity (H3-T3 specific)
GO:0072354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3T3 kinase activity
GO:0072354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-threonine kinase activity (H3-T3 specific)
GO:0072354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-T3 kinase activity
GO:0050530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	salt tolerance protein A
GO:0050530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	StpA
GO:0050530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosylglycerol 3-phosphatase activity
GO:0050530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity
REACT:R-HSA-6807496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU2F1 (OCT1) or POU2F2 (OCT2), SP1, and ZNF143 (STAF) bind the DSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
REACT:R-DRE-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Danio rerio)
REACT:R-HSA-110356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MPG glycosylase by APEX1 at the AP site (Homo sapiens)
REACT:R-GGA-5654667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)
REACT:R-RNO-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Rattus norvegicus)
REACT:R-XTR-5691006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Xenopus tropicalis)
RHEA:20563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + glycolaldehyde => 3-hydroxypyruvate + H(+)
REACT:R-XTR-4551616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RPA1 (RPA70) with SUMO2,3 (Xenopus tropicalis)
REACT:R-GGA-6809006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Gallus gallus)
REACT:R-GGA-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Gallus gallus)
REACT:R-RNO-211948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 can N-demethylate loperamide (Rattus norvegicus)
REACT:R-XTR-428918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:G13 complex (Xenopus tropicalis)
RHEA:54414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5beta-steroid + NADP(+)
REACT:R-XTR-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Xenopus tropicalis)
RHEA:17544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic primary alcohol + O2 <=> an aromatic aldehyde + H2O2
REACT:R-MMU-6799409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates TP53 (Mus musculus)
REACT:R-BTA-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Bos taurus)
RHEA:19875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate => dehydroepiandrosterone 3-sulfate + H2O
RHEA:59815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]
REACT:R-CEL-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)
REACT:R-DME-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)
REACT:R-HSA-5252072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AZGP1 binds PIP (Homo sapiens)
REACT:R-HSA-9603420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 promotes SRC autophosphorylation (Homo sapiens)
REACT:R-SSC-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Sus scrofa)
REACT:R-HSA-997309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of STAT1 by SHP2 (Homo sapiens)
REACT:R-DDI-1482887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)
RHEA:40960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-BTA-8865237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD6 methylates RELA in the NFkB complex (Bos taurus)
REACT:R-SPO-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Schizosaccharomyces pombe)
REACT:R-PFA-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Plasmodium falciparum)
REACT:R-MMU-3928617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB2 binds KALRN (Mus musculus)
RHEA:57514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => chlorobenzene + H(+) + NADH + O2
REACT:R-XTR-2984226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NEK9 (Xenopus tropicalis)
REACT:R-CEL-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Caenorhabditis elegans)
REACT:R-BTA-5625738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Bos taurus)
REACT:R-GGA-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)
RHEA:34926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(in) <=> nitrate(out)
RHEA:36141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + AMP + diphosphate => (E)-hexadec-2-enoate + ATP + CoA
RHEA:59314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactono-1,5-lactone + H2O2 => D-galactose + O2
RHEA:62903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)
REACT:R-DRE-1181153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Danio rerio)
REACT:R-SSC-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Sus scrofa)
RHEA:54479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)
RHEA:62715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone C + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin I
REACT:R-DRE-2730889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to the membrane by binding active RAC1 (Danio rerio)
REACT:R-CFA-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Canis familiaris)
RHEA:58202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-aminohexanoate
REACT:R-CFA-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Canis familiaris)
REACT:R-CFA-9020610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Canis familiaris)
REACT:R-SSC-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Sus scrofa)
REACT:R-CFA-196350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Canis familiaris)
RHEA:13889	skos:altLabel	"FAD pyrophosphatase"
RHEA:13889	skos:prefLabel	"FAD diphosphatase"
RHEA:13889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H2O = AMP + FMN + 2 H(+)
RHEA:13889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FAD diphosphatase"
RHEA:21674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine
RHEA:64231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:48424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP
REACT:R-BTA-4551768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO2,3 (Bos taurus)
REACT:R-GGA-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)
RHEA:65615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:20111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + ADP => alpha-D-ribose 1,5-bisphosphate + ATP
REACT:R-DRE-2130640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of clathrin coated vesicle by Ii (Danio rerio)
REACT:R-HSA-9614273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGRG heterodimer translocates to plasma membrane (Homo sapiens)
GO:0140345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine flippase activity (exoplasmic to cytosolic leaftlet)
GO:0140345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine flippase activity
RHEA:66704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mycophenolyl-CoA = CoA + H(+) + mycophenolate
REACT:R-BTA-8984021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Bos taurus)
REACT:R-BTA-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)
REACT:R-SCE-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Saccharomyces cerevisiae)
REACT:R-CFA-1296037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with large conductance (Canis familiaris)
GO:0047810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine:2-oxoglutarate aminotransferase activity
GO:0047810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aspartate aminotransferase activity
GO:0047810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aspartate transaminase activity
GO:0047810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanine-D-glutamate transaminase activity
GO:0047810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine aminotransferase activity
GO:0047810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-amino acid aminotransferase activity
GO:0047810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-amino acid transaminase activity
GO:0047810	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aspartic aminotransferase activity
GO:0047810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-amino-acid transaminase activity
GO:0047810	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-alanine transaminase activity
RHEA:37453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA
RHEA:15610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
RHEA:60117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + methylphosphonate + O2 => CO2 + hydroxymethylphosphonate + succinate
REACT:R-CFA-76456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-atom dealkylation of dextromethorphan (Canis familiaris)
REACT:R-BTA-5686301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 binds SFTPAs (Bos taurus)
RHEA:10061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-tryptophan => CoA + H(+) + N-acetyl-D-tryptophan
RHEA:52212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:54949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] => (2E,5Z)-dodecadienoyl-[ACP] + H2O
REACT:R-RNO-8863914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of SEC22B, TAP and PLC from ER to ERGIC (Rattus norvegicus)
GO:0018733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydrocoumarin hydrolase activity
RHEA:50402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + S-octanoyl-L-cysteinyl-[PqsC protein] => L-cysteinyl-[PqsC protein] + octanoyl-CoA
RHEA:67117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:51067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + lithocholate <=> adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate
REACT:R-CFA-2002440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen C-propeptides (Canis familiaris)
RHEA:13507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H2O2 => choline + O2
RHEA:46744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate = ADP + carboxyphosphate
RHEA:17495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dihydroxyacetone => A + glycerol
REACT:R-GGA-2730841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV (Gallus gallus)
REACT:R-RNO-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Rattus norvegicus)
REACT:R-GGA-983700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds the activated BCR (Gallus gallus)
RHEA:29479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-epicubenol synthase"
RHEA:29479	skos:altLabel	"farnesyl pyrophosphate cyclase"
RHEA:29479	skos:prefLabel	"(+)-epicubenol synthase"
RHEA:29479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (+)-epicubenol + diphosphate
GO:0047662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminobenzoate carboxy-lyase (aniline-forming)
GO:0047662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminobenzoate decarboxylase activity
GO:0047662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminobenzoate carboxy-lyase activity
REACT:R-XTR-1028817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Xenopus tropicalis)
REACT:R-CFA-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Canis familiaris)
REACT:R-MMU-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Mus musculus)
REACT:R-SSC-549322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations out of hepatic cells (Sus scrofa)
RHEA:32694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (E)-beta-ocimene + diphosphate
REACT:R-SSC-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Sus scrofa)
RHEA:56319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4-hydroxybenzoate + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzoate + CoA
REACT:R-BTA-9684627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds CYSLTR1 antagonists (Bos taurus)
REACT:R-SSC-2424246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind lecticans (Sus scrofa)
REACT:R-DRE-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Danio rerio)
RHEA:65607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + eicosanoyl-CoA <=> CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine
REACT:R-HSA-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Homo sapiens)
REACT:R-DRE-9025995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Danio rerio)
REACT:R-SSC-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Sus scrofa)
RHEA:39773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-109514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Mus musculus)
REACT:R-CEL-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)
REACT:R-CFA-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)
RHEA:28135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hesperidin + H2O => (2S)-hesperetin + rutinose
REACT:R-RNO-508247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
RHEA:65553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + lactose
RHEA:25304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+) => 7,8-dihydroneopterin 3'-triphosphate + H2O
RHEA:53626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + tsukubadiene => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-RNO-2187358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters unphosphorylated SMAD2/3 (Rattus norvegicus)
RHEA:32466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + 2 S-adenosyl-L-methionine <=> 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine
RHEA:42586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O
REACT:R-BTA-9008692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds SMAD3 (Bos taurus)
REACT:R-HSA-6793275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMVPP65 binds NCR3 (Homo sapiens)
RHEA:12757	skos:prefLabel	"zeatin reductase"
RHEA:12757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin
RHEA:12757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zeatin reductase"
REACT:R-DRE-211951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1B1 4-hydroxylates EST17b (Danio rerio)
RHEA:23938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)
REACT:R-PFA-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Plasmodium falciparum)
RHEA:12485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-phosphate + H2O => a ribonucleoside + phosphate
REACT:R-HSA-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Homo sapiens)
RHEA:54521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => cycloaraneosene + diphosphate
RHEA:56773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-adonixanthin + 2 O2 => 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O
RHEA:49230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + geranylgeranyl-bacteriochlorophyllide a => (2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+)
REACT:R-DME-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Drosophila melanogaster)
REACT:R-SPO-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)
RHEA:65774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0102442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syringetin 3-O-methyltransferase activity
RHEA:65049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetoxybenzyl alcohol + NAD(+) => 4-acetoxybenzaldehyde + H(+) + NADH
GO:0031718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 cannabinoid receptor binding
GO:0031718	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 cannabinoid receptor ligand
RHEA:10586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+) => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH
REACT:R-RNO-4411402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NLK (Rattus norvegicus)
GO:0050390	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-valine carboxy-lyase activity
GO:0050390	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine decarboxylase activity
GO:0050390	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-valine carboxy-lyase (2-methylpropanamine-forming)
GO:0050390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine decarboxylase activity
REACT:R-RNO-9018858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Rattus norvegicus)
RHEA:10677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate => 2-isopropylmaleate + H2O
GO:0050590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desacetoxyvindoline-4-hydroxylase activity
GO:0050590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity
GO:0050590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desacetyoxyvindoline-17-hydroxylase activity
GO:0050590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)
GO:0050590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D17H activity
GO:0050590	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)
GO:0050590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desacetoxyvindoline 4-hydroxylase activity
RHEA:55860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1236967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alkalization of the phagosomal lumen by NOX2 (Rattus norvegicus)
REACT:R-XTR-70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer oxidises LACT to PYR (Xenopus tropicalis)
RHEA:55560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate
REACT:R-DME-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Drosophila melanogaster)
REACT:R-HSA-9667619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B,2 bind atosiban (Homo sapiens)
RHEA:14495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + L-arginyl-[dinitrogen reductase] => H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase]
GO:0051740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethene binding
GO:0051740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylene binding
GO:0102837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity
RHEA:32300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate + H(+) + NADH => 2 diphosphate + NAD(+) + squalene
REACT:R-DRE-5693574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Danio rerio)
RHEA:53087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP
REACT:R-CFA-350058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL NCOR corepressor complex (Canis familiaris)
RHEA:10675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclobutadithymidine in DNA <=> a thymidine dimer in DNA
RHEA:42230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + estrone => 17beta-estradiol + A
REACT:R-HSA-8864395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression (Homo sapiens)
REACT:R-XTR-173740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to C3(H2O) (Xenopus tropicalis)
REACT:R-XTR-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Xenopus tropicalis)
RHEA:59209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + octadecanoate => diphosphate + octadecanoyl-AMP
REACT:R-MMU-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Mus musculus)
REACT:R-HSA-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)
REACT:R-HSA-416725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA6D binds to PLXNA1:TREM2:DAP12 (Homo sapiens)
RHEA:44338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate => an L-alpha-amino acid + ATP + L-arginine
REACT:R-HSA-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)
RHEA:72492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + maleate(in) => citrate(in) + maleate(out)
REACT:R-DME-975902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Drosophila melanogaster)
RHEA:34256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sporulenol => (R)-tetraprenyl-beta-curcumene + H2O
REACT:R-RNO-111915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK4 autophosphorylates (Rattus norvegicus)
RHEA:42384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4'-diaponeurosporenal + H2O + NAD(+) = 4,4'-diaponeurosporenoate + 2 H(+) + NADH
RHEA:59210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + octadecanoyl-AMP => ATP + H(+) + octadecanoate
RHEA:24779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pheophorbide a <=> C-13(2)-carboxypyropheophorbide a + methanol
REACT:R-BTA-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Bos taurus)
REACT:R-HSA-9751037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:58624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate
RHEA:19492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide <=> 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)
REACT:R-HSA-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Homo sapiens)
REACT:R-BTA-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Bos taurus)
REACT:R-DME-209172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CI by SGG (Drosophila melanogaster)
RHEA:61960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Drosophila melanogaster)
REACT:R-HSA-1296037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with large conductance (Homo sapiens)
REACT:R-RNO-9618378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 binds the Nup107-Nup160 complex (Rattus norvegicus)
REACT:R-HSA-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Homo sapiens)
REACT:R-XTR-167408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The high affinity receptor complex binds to G-protein (Xenopus tropicalis)
REACT:R-DRE-5625796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM4C binds KLK2 and KLK3 promoters (Danio rerio)
REACT:R-DME-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Drosophila melanogaster)
REACT:R-DRE-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Danio rerio)
RHEA:17276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) <=> 4-hydroxyphenylacetate + 2 H(+) + NADH
REACT:R-BTA-8849891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-3 bind to PSD-95 family members (Bos taurus)
REACT:R-DRE-5610722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI3 (Danio rerio)
RHEA:67207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyltryptamine <=> acetate + tryptamine
RHEA:46255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CEL-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Caenorhabditis elegans)
RHEA:30782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + FAD + H(+) <=> 2-dehydro-D-gluconate + FADH2
RHEA:41166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-amino-sn-glycerol + ATP <=> 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)
GO:0004411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homogentisate oxygenase activity
GO:0004411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homogentisate dioxygenase activity
GO:0004411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homogentisate oxidase activity
GO:0004411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homogentisic acid oxidase activity
GO:0004411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
GO:0004411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homogentisic oxygenase activity
GO:0004411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homogentisicase activity
GO:0004411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homogentisic acid oxygenase activity
GO:0004411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate 1,2-dioxygenase activity
RHEA:33455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxyzymosterol + NADP(+) = CO2 + NADPH + zymosterone
RHEA:71709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-phenylalanyl-L-phenylalanine(in) => H(+)(out) + L-phenylalanyl-L-phenylalanine(out)
REACT:R-CFA-112435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin BC complex (Canis familiaris)
REACT:R-GGA-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Gallus gallus)
RHEA:19690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnulose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate
RHEA:52944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + UDP-alpha-D-glucuronate = choloyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-CFA-4085372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO2,3 (Canis familiaris)
REACT:R-CFA-983703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)
GO:1905577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GP1c binding
REACT:R-DME-209245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinase Hopscotch (HOP) binds to the transmembrane cytokine receptor Domeless (DOME) to form the HOP:DOME complex (Drosophila melanogaster)
REACT:R-MMU-5693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYM reduces P2C to PPCA (Mus musculus)
RHEA:26031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:59751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]
REACT:R-CFA-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Canis familiaris)
RHEA:18528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol + NADP(+) <=> 3-methylbutanal + H(+) + NADPH
REACT:R-DME-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Drosophila melanogaster)
GO:0016690	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ligninase I activity
GO:0016690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lignin peroxidase activity
GO:0016690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)
GO:0016690	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	LiP activity
GO:0016690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity
GO:0016690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diarylpropane peroxidase activity
GO:0016690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diarylpropane oxygenase activity
GO:0016690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ligninase activity
RHEA:66186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP(out) + ADP + H(+) + phosphate => 3',5'-cyclic AMP(in) + ATP + H2O
REACT:R-SCE-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Saccharomyces cerevisiae)
RHEA:63610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apelin-16 + L-phenylalanine => apelin-17 + H2O
REACT:R-DDI-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Dictyostelium discoideum)
RHEA:36761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-MMU-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Mus musculus)
RHEA:10774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + D-glucose 6-phosphate => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O
REACT:R-BTA-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Bos taurus)
RHEA:38401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O
REACT:R-DDI-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Dictyostelium discoideum)
RHEA:49102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester => H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine
REACT:R-DRE-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)
REACT:R-SSC-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Sus scrofa)
REACT:R-CFA-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Canis familiaris)
REACT:R-SSC-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Sus scrofa)
REACT:R-CFA-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Canis familiaris)
RHEA:72967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) = 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)
REACT:R-CEL-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Caenorhabditis elegans)
RHEA:29249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+)(in) + 2 Na(+)(out) => 3 H(+)(out) + 2 Na(+)(in)
REACT:R-GGA-8987096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)
RHEA:65922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine => L-kynurenine + pyruvate
GO:0102544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornaline synthase activity
REACT:R-GGA-8939801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades PolyUb-RUNX2 (Gallus gallus)
REACT:R-BTA-375140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds promyogenic cadherins (Bos taurus)
REACT:R-DME-9653503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B is phosphorylated on serine 181 (Drosophila melanogaster)
RHEA:17646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate
RHEA:70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylputrescine + O2 <=> 4-acetamidobutanal + H2O2 + NH4(+)
REACT:R-DRE-6805479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53RK phosphorylates TP53 (Danio rerio)
REACT:R-GGA-9667914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand midkine (MDK) (Gallus gallus)
REACT:R-DDI-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Dictyostelium discoideum)
RHEA:60877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)
REACT:R-GGA-990489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-13 is a dimer (Gallus gallus)
RHEA:11941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + L-citrulline => CO2 + L-ornithine + NH4(+)
EC:2.6.1.77	skos:prefLabel	"taurine--pyruvate aminotransferase"
EC:2.6.1.77	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taurine--pyruvate aminotransferase"
REACT:R-SSC-5692770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Sus scrofa)
REACT:R-HSA-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Homo sapiens)
REACT:R-CFA-1295613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds GRB2 (Canis familiaris)
RHEA:22931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanoyl-CoA + H2O <=> 4-aminobutanoyl-CoA + acetate
GO:0005173	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	stem cell factor receptor ligand
GO:0005173	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SCF
GO:0005173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCFR binding
GO:0005173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stem cell factor receptor binding
GO:0005173	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	KIT binding
GO:0005173	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	stem cell factor
RHEA:11821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthamide-[translation elongation factor 2] + NAD(+) => H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide
RHEA:25226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NAD(+) => H(+) + L-arabinose + NADH
RHEA:28895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine(in) + L-lysine(out) = cadaverine(out) + L-lysine(in)
REACT:R-CEL-217255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO1:FAD N-oxidises TAM (Caenorhabditis elegans)
REACT:R-BTA-5218806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN autophosphorylates (Bos taurus)
REACT:R-GGA-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Gallus gallus)
RHEA:31408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diaponeurosporene + FAD + H(+) => all-trans-4,4'-diapolycopene + FADH2
REACT:R-DRE-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Danio rerio)
GO:0004510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan hydroxylase activity
GO:0004510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan 5-hydroxylase activity
GO:0004510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan 5-monooxygenase activity
GO:0004510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan hydroxylase activity
GO:0004510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleacetic acid-5-hydroxylase activity
GO:0004510	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
REACT:R-HSA-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Homo sapiens)
REACT:R-SSC-5695989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD11 dehydrogenates BH-CoA (Sus scrofa)
REACT:R-DME-1655842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P hydrolyzes SREBP1A,1C,2 (Drosophila melanogaster)
GO:0047308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-ketomalonate (mesoxalate) transaminase activity
GO:0047308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine-oxomalonate aminotransferase activity
GO:0047308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine--oxomalonate aminotransferase activity
GO:0047308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine-ketomalonate transaminase activity
GO:0047308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine:oxomalonate aminotransferase activity
GO:0047308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine-oxomalonate transaminase activity
RHEA:63027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenamide + H2O <=> (13Z)-docosenoate + NH4(+)
REACT:R-RNO-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Rattus norvegicus)
REACT:R-GGA-373339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Gallus gallus)
RHEA:43428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-BTA-5684801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y7-CLEC1B dimer:PDPN binds SYK (Bos taurus)
REACT:R-BTA-8854052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the SCF-FBXL7 complex (Bos taurus)
GO:0030551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic nucleotide binding
RHEA:12559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-glucono-1,5-lactone + H2O <=> 6-phospho-D-gluconate + H(+)
EC:3.1.1.75	skos:altLabel	"poly(HASCL) depolymerase"
EC:3.1.1.75	skos:altLabel	"poly(HA) depolymerase"
EC:3.1.1.75	skos:prefLabel	"poly(3-hydroxybutyrate) depolymerase"
EC:3.1.1.75	skos:altLabel	"poly[(R)-hydroxyalkanoic acid] depolymerase"
EC:3.1.1.75	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"poly(3-hydroxybutyrate) depolymerase"
EC:3.1.1.75	skos:altLabel	"PHB depolymerase"
EC:3.1.1.75	skos:altLabel	"poly(3HB) depolymerase"
RHEA:44334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + bacilysin + H(+) + phosphate => ATP + L-alanine + L-anticapsin
GO:0018863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity
GO:0003713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription coactivator activity
GO:0003713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription co-activator activity
GO:0003713	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcription co-activator activity
GO:0003713	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcription coactivator activity
GO:0003713	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcription mediator activity
REACT:R-CFA-8982165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Canis familiaris)
GO:0050574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity
GO:0050574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(R)-hydroxypropyl-CoM dehydrogenase activity
GO:0050574	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity
REACT:R-DME-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Drosophila melanogaster)
RHEA:36910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA
REACT:R-SCE-1482868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Saccharomyces cerevisiae)
RHEA:36507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetracosanoyl-CoA + CO2 + CoA
REACT:R-GGA-936941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Gallus gallus)
RHEA:52306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetamido-4-aminobutanoate => H2O + L-ectoine
RHEA:45289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 => 2-glyceryl-prostaglandin G2
REACT:R-XTR-6781905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZRANB1 binds APC (Xenopus tropicalis)
RHEA:15282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol => 5alpha-cholest-8-en-3beta-ol
REACT:R-XTR-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Xenopus tropicalis)
REACT:R-MMU-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Mus musculus)
REACT:R-SSC-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Sus scrofa)
REACT:R-HSA-1562640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)
REACT:R-DRE-77340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Danio rerio)
RHEA:58064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin = 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-400509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Danio rerio)
REACT:R-MMU-2130478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of invariant chain trimer and MHC II alpha beta dimer (Mus musculus)
EC:4.99.1.5	skos:prefLabel	"aliphatic aldoxime dehydratase"
EC:4.99.1.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aliphatic aldoxime dehydratase"
REACT:R-MMU-201472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Mus musculus)
RHEA:37969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + H(+) + NADPH => galactitol + NADP(+)
GO:0042043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurexin family protein binding
GO:0042043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neuroligin
REACT:R-MMU-9036727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAA hydrolyzes lysosomal glycogen (Mus musculus)
REACT:R-CFA-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Canis familiaris)
RHEA:67259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + propanal <=> 2 H(+) + NADH + propanoate
REACT:R-CEL-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Caenorhabditis elegans)
RHEA:57082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione => glutathione + S-methyl-1-thio-D-xylulose 5-phosphate
RHEA:37317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-glutamine => glycyl-L-glutamine + H2O
REACT:R-DRE-201628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at DSVD (85) (Danio rerio)
RHEA:48453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA2 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine
EC:7.3.-.-	skos:prefLabel	"Catalysing the translocation of inorganic anions and their chelates"
EC:7.3.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Catalysing the translocation of inorganic anions and their chelates"
REACT:R-HSA-3247493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO1 (Homo sapiens)
REACT:R-DRE-6807106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN undergoes monoubiquitination (Danio rerio)
REACT:R-DRE-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Danio rerio)
REACT:R-RNO-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Rattus norvegicus)
REACT:R-HSA-1236954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides by IRAP in endocytic vesicles (Homo sapiens)
REACT:R-DME-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-BTA-1878002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLTs transfer Xyl to core protein (Bos taurus)
RHEA:41753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)
REACT:R-MMU-3343700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
REACT:R-GGA-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Gallus gallus)
RHEA:32065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGMP + H(+) + phosphate => 8-oxo-dGDP + H2O
RHEA:34360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + H2O => a 2-acylglycerol + a carboxylate + H(+)
REACT:R-HSA-1236940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exogenous soluble antigen targeted to more stable early endosome (Homo sapiens)
REACT:R-GGA-2984258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 phosphorylates NEK6/NEK7 (Gallus gallus)
GO:0102150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-myristoyl-CoA hydrolase activity
RHEA:36218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
REACT:R-XTR-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Xenopus tropicalis)
REACT:R-SSC-879674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD97 binds CD55 (Sus scrofa)
RHEA:63522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-isopropylcatechol + H2O + NAD(+) => 2-isopropylphenol + H(+) + NADH + O2
REACT:R-GGA-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Gallus gallus)
REACT:R-HSA-9617832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO4:ATXN3 binds SOD2 gene promoter (Homo sapiens)
RHEA:32261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde => beta-D-fructose 1-phosphate + methylglyoxal
RHEA:41405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-methylpyrrolidine + NADP(+) => 2-methyl-1-pyrroline + H(+) + NADPH
REACT:R-DRE-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Danio rerio)
REACT:R-CFA-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Canis familiaris)
RHEA:36914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA
RHEA:58982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7-dimethylocta-2,6-dienoate + H(+) + H2O2 => citral + H2O + O2
REACT:R-CEL-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)
RHEA:49994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + propan-2-ol => H(+) + NADH + O2 + propane
REACT:R-SSC-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Sus scrofa)
REACT:R-GGA-433981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 (Gallus gallus)
REACT:R-CFA-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Canis familiaris)
RHEA:42114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + progesterone => (20S)-hydroxypregn-4-en-3-one + NADP(+)
REACT:R-DRE-9021609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR-associated SRC autophosphorylates (Danio rerio)
RHEA:71484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Met-enkephalin => L-phenylalanyl-L-methionine + L-tyrosylglycylglycine
RHEA:46954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:53689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
RHEA:59023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)
REACT:R-HSA-2730887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation and activation of MEKK1 (Homo sapiens)
REACT:R-GGA-9021596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane estrogen receptors bind SRC (Gallus gallus)
RHEA:18190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)
REACT:R-XTR-420123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like receptor 2 binds GLP2 (Xenopus tropicalis)
REACT:R-HSA-2426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the DHCR7 promoter (Homo sapiens)
REACT:R-SSC-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Sus scrofa)
REACT:R-CFA-1483159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho is dephosphorylated to Cho by PHOSPHO1 (Canis familiaris)
RHEA:13465	skos:altLabel	"oxalyldiaminopropionate synthase"
RHEA:13465	skos:altLabel	"oxalyldiaminopropionic synthase"
RHEA:13465	skos:prefLabel	"2,3-diaminopropionate N-oxalyltransferase"
RHEA:13465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + oxalyl-CoA = CoA + N(3)-oxalyl-L-2,3-diaminopropanoate
RHEA:13465	skos:altLabel	"ODAP synthase"
RHEA:13465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-diaminopropionate N-oxalyltransferase"
RHEA:55675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
RHEA:70381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetradecanoyl-3-oxosphinganine => 3-oxosphinganine + tetradecanoyl-CoA
RHEA:18535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + serotonin => 5-hydroxy-L-tryptophan + H(+)
GO:0102174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity
GO:0102174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-MMU-9708866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-F2R binds vorapaxar (Mus musculus)
RHEA:12319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:48646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde => prostaglandin H2
GO:0050127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CSHase activity
GO:0050127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-carbamoylsarcosine amidase activity
GO:0050127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoylsarcosine amidase activity
GO:0050127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-carbamoylsarcosine amidohydrolase activity
REACT:R-DME-209108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound GISH binds to ARR receptor complex (Drosophila melanogaster)
REACT:R-XTR-8932955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:11061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-isoleucine + tRNA(Ile) => AMP + diphosphate + L-isoleucyl-tRNA(Ile)
REACT:R-DRE-8848338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes TAG (Danio rerio)
RHEA:43815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-BTA-9014420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the phagocytic vesicle membrane (Bos taurus)
REACT:R-SSC-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Sus scrofa)
RHEA:29368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H2O => cytidine + phosphate
REACT:R-DME-209371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGS binds to ARM (Drosophila melanogaster)
REACT:R-BTA-3781011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Bos taurus)
GO:0004568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-poly-N-acetyl glucosamidinase activity
GO:0004568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-poly-N-acetylglucosaminidase activity
GO:0004568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly-beta-glucosaminidase activity
GO:0004568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity
GO:0004568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitodextrinase activity
GO:0004568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitinase activity
RHEA:69681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin + beta-D-glucose => apigenin 7-O-beta-D-glucoside + H2O
RHEA:54483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
RHEA:48844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
RHEA:40892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine
REACT:R-DRE-5610752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R translocates to the nucleus (Danio rerio)
REACT:R-CFA-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Canis familiaris)
RHEA:63932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisate(in) + ATP + H2O = abscisate(out) + ADP + H(+) + phosphate
GO:0047934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose 1-dehydrogenase (NAD+) activity
GO:0047934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH
GO:0047934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aldohexose dehydrogenase activity
GO:0047934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose:NAD+ 1-oxidoreductase activity
GO:0047934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose:NAD oxidoreductase activity
RHEA:49030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:45322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine => H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine
RHEA:72064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate(out) + 2 Na(+)(out) => glycoursodeoxycholate(in) + 2 Na(+)(in)
REACT:R-DRE-9012315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Danio rerio)
REACT:R-SSC-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Sus scrofa)
REACT:R-RNO-5693609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53 at S15 (Rattus norvegicus)
RHEA:34946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) <=> arbutin 6-phosphate(in) + pyruvate(in)
REACT:R-SSC-201425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Sus scrofa)
RHEA:32945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-ethanolamine
REACT:R-DRE-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Danio rerio)
RHEA:34134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neryl diphosphate + olivetolate <=> cannabinerolate + diphosphate
RHEA:60243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate
REACT:R-DRE-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
REACT:R-XTR-419841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Light stimulates opsin receptors (Xenopus tropicalis)
REACT:R-BTA-75879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Bos taurus)
RHEA:51585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-SCE-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Saccharomyces cerevisiae)
REACT:R-XTR-375339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Xenopus tropicalis)
REACT:R-HSA-9007462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC7 gene expression is repressed by the PRC1L4 complex (Homo sapiens)
REACT:R-SSC-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Sus scrofa)
REACT:R-DRE-1855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Danio rerio)
RHEA:58387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octan-1-ol <=> H(+) + NADPH + octanal
REACT:R-CEL-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Caenorhabditis elegans)
RHEA:56896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + ATP + H(+) = an acyl-AMP + diphosphate
REACT:R-SCE-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Saccharomyces cerevisiae)
REACT:R-SSC-8863471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR is bound by DAB2 and ARH (Sus scrofa)
RHEA:56631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O <=> chloride + 2 H(+) + maleylacetate
REACT:R-DME-204798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and p85 of PI3K (Drosophila melanogaster)
REACT:R-HSA-156908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eEF1A:GTP:aminoacyl tRNA ternary complex formation. (Homo sapiens)
REACT:R-BTA-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Bos taurus)
REACT:R-DRE-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Danio rerio)
RHEA:34601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH => 15-methylhexadecasphinganine + NADP(+)
RHEA:67493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)
REACT:R-HSA-984609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-8 is a dimer (Homo sapiens)
REACT:R-CFA-5635842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3 phosphorylates GLI (Canis familiaris)
RHEA:66557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + L-glutaminyl-[protein] => 5-dopaminyl-L-glutamyl-[protein] + NH4(+)
REACT:R-XTR-4086392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)
GO:0032115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Sou1p
GO:0032115	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucitol:NADP+ oxidoreductase activity
GO:0032115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbose reductase activity
GO:0018531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-6-hydroxynicotine oxidase activity
GO:0018531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-L-nicotine oxidase activity
GO:0018531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxy-L-nicotine:oxygen oxidoreductase activity
GO:0018531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-6-hydroxynicotine:oxygen oxidoreductase activity
GO:0018531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-6-hydroxynicotine oxidase activity
REACT:R-CFA-444705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R1/T1R3 dimer is the umami taste receptor (Canis familiaris)
REACT:R-RNO-158721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Rattus norvegicus)
REACT:R-HSA-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Homo sapiens)
REACT:R-MMU-174251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Mus musculus)
REACT:R-PFA-8848355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes retinyl palmitate (Plasmodium falciparum)
RHEA:32090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate <=> [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate
RHEA:36104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + S-adenosyl-L-methionine => O-methyl anthranilate + S-adenosyl-L-homocysteine
RHEA:33813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O => 3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine
RHEA:43619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-DDI-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Dictyostelium discoideum)
RHEA:57457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP
RHEA:31634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate <=> phosphate + pseudaminate
REACT:R-BTA-1169397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ISG15 by UBA7 E1 ligase (Bos taurus)
REACT:R-SSC-983285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B binds RAD51C (Sus scrofa)
REACT:R-DME-8871226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA2 (Drosophila melanogaster)
RHEA:43129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine
RHEA:40558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)
RHEA:29906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose(out) + H2O <=> ADP + D-ribose(in) + H(+) + phosphate
REACT:R-MMU-420595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-2:Nectin 3 trans heterodimer interaction (Mus musculus)
REACT:R-MMU-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Mus musculus)
GO:0004778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl coenzyme A deacylase activity
GO:0004778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA hydrolase activity
GO:0004778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA acylase activity
GO:0004778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl coenzyme A hydrolase activity
GO:0019970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-11 binding
GO:0019970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-11 binding
RHEA:64218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-lyxonate => 2-carboxy-L-lyxonate + H(+)
RHEA:70636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:30445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => 2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc
RHEA:67382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + L-cysteine => H2O + L-alanyl-L-cysteine
GO:0046539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity
GO:0046539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histamine methyltransferase activity
GO:0046539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazolemethyltransferase activity
GO:0046539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine N-methyltransferase activity
GO:0046539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histamine 1-methyltransferase activity
GO:0046539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histamine-methylating enzyme
GO:0046539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine-histamine N-methyltransferase activity
RHEA:55890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[excited state blue fluorescent protein] + CO2 => [aequorin]--dioxetanone
RHEA:70728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O => 6-sulfo-alpha-D-quinovose + glycerol
REACT:R-RNO-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Rattus norvegicus)
RHEA:38481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine => N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine
REACT:R-CFA-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Canis familiaris)
RHEA:57903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 <=> adenosine in U6 snRNA + CO2 + formaldehyde + succinate
RHEA:18700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + H(+) <=> (4-hydroxyphenyl)acetaldehyde + CO2
RHEA:25048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O
REACT:R-HSA-1678921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length TLR3/7/8/9 binds to UNC93B1 (Homo sapiens)
REACT:R-RNO-114354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP:Caspase-7 (Rattus norvegicus)
REACT:R-XTR-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Xenopus tropicalis)
RHEA:23284	skos:altLabel	"isopentenylpyrophosphate Delta-isomerase"
RHEA:23284	skos:prefLabel	"isopentenyl-diphosphate Delta-isomerase"
RHEA:23284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopentenyl-diphosphate Delta-isomerase"
RHEA:23284	skos:altLabel	"methylbutenylpyrophosphate isomerase"
RHEA:23284	skos:altLabel	"isopentenylpyrophosphate isomerase"
RHEA:23284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyl diphosphate = dimethylallyl diphosphate
RHEA:23284	skos:altLabel	"IPP isomerase"
RHEA:57174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + NADH => (S)-2-hydroxyglutarate + NAD(+)
REACT:R-CFA-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Canis familiaris)
REACT:R-DRE-9007882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 is cleaved (Danio rerio)
REACT:R-GGA-5654224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds PLCG1 (Gallus gallus)
REACT:R-SSC-5624954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INPP5E translocates to the primary cilium (Sus scrofa)
REACT:R-RNO-202212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to LAT (Rattus norvegicus)
REACT:R-DRE-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Danio rerio)
GO:0042561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-amyrin synthase activity
REACT:R-DDI-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Dictyostelium discoideum)
REACT:R-RNO-430021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAN2-PAN3 complex partially deadenylates mRNA (Rattus norvegicus)
RHEA:57815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-2-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite
RHEA:50394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline
REACT:R-HSA-5578966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A:AGO2:miRNA is transported into the nucleus (Homo sapiens)
RHEA:62760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DDI-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Dictyostelium discoideum)
REACT:R-MMU-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)
RHEA:66591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 26S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-203553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS binds NOSIP (Homo sapiens)
REACT:R-SSC-421426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ProGIP translocates from the ER Lumen to secretory granules (Sus scrofa)
REACT:R-RNO-9674816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Rattus norvegicus)
RHEA:52950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholoyl-24-O-(beta-D-glucuronate) + UDP => deoxycholate + UDP-alpha-D-glucuronate
RHEA:25676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O
REACT:R-BTA-1592316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP1 (Bos taurus)
RHEA:39076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenedioyl-CoA + H2O => (3S)-hydroxydodecanedioyl-CoA
REACT:R-CFA-203625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)
REACT:R-CEL-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Caenorhabditis elegans)
REACT:R-CEL-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Caenorhabditis elegans)
REACT:R-DME-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Drosophila melanogaster)
RHEA:54881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3R)-3-isopropenyl-6-oxoheptanoate + H(+)
REACT:R-SSC-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Sus scrofa)
REACT:R-HSA-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Homo sapiens)
RHEA:47836	skos:prefLabel	"[5-(aminomethyl)furan-3-yl]methyl phosphate kinase"
RHEA:47836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[5-(aminomethyl)furan-3-yl]methyl phosphate kinase"
RHEA:47836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[5-(aminomethyl)-3-furyl]methyl phosphate + ATP = [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP
RHEA:15946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]
REACT:R-HSA-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Homo sapiens)
REACT:R-RNO-264834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis and degradation of apoA-I (Rattus norvegicus)
RHEA:21927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + NAD(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADH
RHEA:71439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
REACT:R-CEL-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
REACT:R-HSA-3000383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I, HDAC7 SUMOylate PML with SUMO1 (Homo sapiens)
RHEA:17378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] => 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)
RHEA:33891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chanoclavine-I + NAD(+) = chanoclavine-I aldehyde + H(+) + NADH
RHEA:33891	skos:prefLabel	"chanoclavine-I dehydrogenase"
RHEA:33891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chanoclavine-I dehydrogenase"
REACT:R-RNO-9706354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of FLT3 (Rattus norvegicus)
REACT:R-SSC-5694487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A4GNT transfers GlcNAc to core 2 mucins (Sus scrofa)
RHEA:27712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + GMP + H(+) => ATP + guanosine
EC:1.14.14.35	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylsulfone monooxygenase"
EC:1.14.14.35	skos:prefLabel	"dimethylsulfone monooxygenase"
REACT:R-DRE-977605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H displaces Bb (Danio rerio)
RHEA:48951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DRE-5689649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 (Danio rerio)
REACT:R-HSA-975098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
REACT:R-RNO-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Rattus norvegicus)
REACT:R-DRE-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Danio rerio)
REACT:R-HSA-5423038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Homo sapiens)
RHEA:33971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5''-phosphoribostamycin + H2O = phosphate + ribostamycin
RHEA:33971	skos:prefLabel	"5''-phosphoribostamycin phosphatase"
RHEA:33971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5''-phosphoribostamycin phosphatase"
EC:3.4.19.16	skos:prefLabel	"glucosinolate gamma-glutamyl hydrolase"
EC:3.4.19.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosinolate gamma-glutamyl hydrolase"
REACT:R-MMU-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Mus musculus)
RHEA:42878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine
REACT:R-RNO-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Rattus norvegicus)
REACT:R-DRE-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Danio rerio)
REACT:R-MMU-5623513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 stimulates GTPase activity of ARF4 (Mus musculus)
RHEA:39858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol
RHEA:18970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + H(+) + hnu => a long-chain alkane + CO2
GO:1903924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estradiol binding
RHEA:40506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine <=> N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine
RHEA:19951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
RHEA:54129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP
EC:3.4.15.4	skos:prefLabel	"peptidyl-dipeptidase B"
EC:3.4.15.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidyl-dipeptidase B"
EC:3.4.15.4	skos:altLabel	"atrial di-(tri-)peptidyl carboxylase"
EC:3.4.15.4	skos:altLabel	"dipeptidyl carboxyhydrolase"
EC:3.4.15.4	skos:altLabel	"atriopeptin convertase"
RHEA:31615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine = dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:31615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase"
RHEA:31615	skos:prefLabel	"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase"
RHEA:65999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) <=> methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine
GO:0003942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-gamma-glutamyl-phosphate reductase activity
GO:0003942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
GO:0003942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, acetyl-gamma-glutamyl phosphate
GO:0003942	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAGSA dehydrogenase activity
GO:0003942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
GO:0003942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglutamate 5-semialdehyde dehydrogenase activity
GO:0003942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglutamic gamma-semialdehyde dehydrogenase activity
GO:0003942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-glutamate semialdehyde dehydrogenase activity
REACT:R-MMU-203070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of profilin with monomeric actin (Mus musculus)
REACT:R-SSC-427527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)
RHEA:21983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)
RHEA:19616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + trimethylsulfonium
RHEA:13598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-diguanidinobutane + H2O => agmatine + urea
REACT:R-HSA-112150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Promoter Opening at Type 2 Promoters (Homo sapiens)
REACT:R-GGA-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Gallus gallus)
REACT:R-RNO-2172126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAP12 interacts with NKG2C (Rattus norvegicus)
REACT:R-SSC-9667619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B,2 bind atosiban (Sus scrofa)
REACT:R-DRE-451418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates IRAK1 (Danio rerio)
REACT:R-DRE-6793685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated TP53 translocates to the cytosol (Danio rerio)
RHEA:38103	skos:prefLabel	"L-galactonate dehydratase"
RHEA:38103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-galactonate dehydratase"
RHEA:38103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactonate = 2-dehydro-3-deoxy-L-galactonate + H2O
RHEA:71493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in)
REACT:R-HSA-8964252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC (Homo sapiens)
REACT:R-SSC-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Sus scrofa)
REACT:R-CFA-9727607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ binds sacubitrilat (Canis familiaris)
RHEA:22169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose => UDP-alpha-D-galactose
REACT:R-HSA-422051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the signal peptide of Preproghrelin (Homo sapiens)
GO:0000297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermine transmembrane transporter activity
REACT:R-MMU-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Mus musculus)
REACT:R-CFA-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Canis familiaris)
RHEA:36624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + S-adenosyl-L-methionine => (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine
RHEA:71648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain (3S)-3-hydroxyacyl-CoA => a medium-chain (2E)-enoyl-CoA + H2O
REACT:R-CEL-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Caenorhabditis elegans)
RHEA:28253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + malonyl-CoA <=> acetoacetyl-CoA + CO2 + CoA
RHEA:31793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate
REACT:R-SSC-9698844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds HSP90:CDC37 (Sus scrofa)
REACT:R-HSA-2972965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter (Homo sapiens)
REACT:R-CFA-2872497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-2 transports cytosolic urate to extracellular region (Canis familiaris)
REACT:R-CEL-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
REACT:R-MMU-5654565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Mus musculus)
REACT:R-HSA-158795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Homo sapiens)
REACT:R-GGA-3927824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CASP8AP2 with SUMO1 (Gallus gallus)
REACT:R-DDI-8876837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB21 GEFs exchange GTP for GDP on RAB21 (Dictyostelium discoideum)
RHEA:63938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a ubiquinol + protoporphyrin IX => 3 a ubiquinone + protoporphyrinogen IX
RHEA:12591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GM2 (d18:1(4E)) + H(+) + UDP
REACT:R-CFA-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Canis familiaris)
REACT:R-DME-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)
RHEA:23372	skos:altLabel	"UDP-acetylmuramyl-L-alanine synthetase"
RHEA:23372	skos:altLabel	"uridine-diphosphate-N-acetylmuramate:L-alanine ligase"
RHEA:23372	skos:altLabel	"UDP-N-acetylmuramyl:L-alanine ligase"
RHEA:23372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylmuramate--L-alanine ligase"
RHEA:23372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
RHEA:23372	skos:altLabel	"uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase"
RHEA:23372	skos:altLabel	"UDP-N-acetylmuramoyl-L-alanine synthetase"
RHEA:23372	skos:prefLabel	"UDP-N-acetylmuramate--L-alanine ligase"
RHEA:23372	skos:altLabel	"UDP-N-acetylmuramoylalanine synthetase"
RHEA:23372	skos:altLabel	"alanine-adding enzyme"
RHEA:23372	skos:altLabel	"MurC synthetase"
RHEA:23372	skos:altLabel	"L-Ala ligase"
RHEA:23372	skos:altLabel	"L-alanine-adding enzyme"
RHEA:23372	skos:altLabel	"UDP-MurNAc:L-alanine ligase"
RHEA:23372	skos:altLabel	"UDPMurNAc-L-alanine synthetase"
RHEA:23372	skos:altLabel	"uridine diphospho-N-acetylmuramoylalanine synthetase"
RHEA:23372	skos:altLabel	"uridine diphosphate N-acetylmuramate:L-alanine ligase"
REACT:R-RNO-2453876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTR:RBP:atROL binds to STRA6 receptor (Rattus norvegicus)
REACT:R-HSA-186826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to the active receptor (Homo sapiens)
REACT:R-SSC-6804596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1:CYCS binds APIP (Sus scrofa)
REACT:R-XTR-351876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of occludin (Xenopus tropicalis)
RHEA:45370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + (9Z)-octadecenoate => H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine
RHEA:68737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] => ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:37591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
RHEA:46914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + juvenile hormone III carboxylate + methanol => H2O + juvenile hormone III
REACT:R-XTR-6805546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I binds keratin type II (Xenopus tropicalis)
REACT:R-DRE-8951676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TEADs and YAP1 (Danio rerio)
REACT:R-XTR-5627072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds GOPC:CFTR (Xenopus tropicalis)
RHEA:38923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H(+) + Na(+)(in) + NADH = a ubiquinol + Na(+)(out) + NAD(+)
REACT:R-PFA-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Plasmodium falciparum)
GO:0046424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferulate 5-hydroxylase activity
GO:0047111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate dehydrogenase (cytochrome c-553)
GO:0047111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate dehydrogenase (cytochrome-c-553) activity
GO:0047111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate:ferricytochrome-c-553 oxidoreductase activity
RHEA:36705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+) => (2S,5S)-5-carboxymethylproline + ATP
REACT:R-CFA-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Canis familiaris)
GO:0033823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	procollagen glucosyltransferase activity
GO:0033823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-collagenglucosyltransferase activity
GO:0033823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity
GO:0033823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosylhydroxylysine glucosyltransferase activity
GO:0033823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	collagen hydroxylysyl glucosyltransferase activity
GO:0033823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosylhydroxylysyl glucosyltransferase activity
GO:0033823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity
GO:0033823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	collagen glucosyltransferase activity
GO:0033823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosylhydroxylysine-glucosyltransferase activity
GO:0033823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-collagen glucosyltransferase activity
RHEA:50868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate
REACT:R-CEL-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Caenorhabditis elegans)
REACT:R-BTA-193737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Bos taurus)
REACT:R-SPO-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Schizosaccharomyces pombe)
REACT:R-DRE-9023840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HATs and coactivators are recruited to the CTSD gene (Danio rerio)
REACT:R-HSA-3640861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)
REACT:R-GGA-9700998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 disrupts the BRCA1:BARD1 heterodimer (Gallus gallus)
REACT:R-RNO-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Rattus norvegicus)
RHEA:37630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-RNO-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Rattus norvegicus)
RHEA:18537	skos:prefLabel	"salicylaldehyde dehydrogenase"
RHEA:18537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salicylaldehyde dehydrogenase"
RHEA:18537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + salicylaldehyde = 2 H(+) + NADH + salicylate
RHEA:28847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Li(+)(in) + melibiose(in) = Li(+)(out) + melibiose(out)
REACT:R-SSC-8956659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates YAP1 (Sus scrofa)
REACT:R-XTR-9027043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYPs hydroxylate DHA to 14(R)-HDHA (Xenopus tropicalis)
REACT:R-DRE-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Danio rerio)
REACT:R-BTA-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Bos taurus)
REACT:R-GGA-114252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-3 by the apoptosome (Gallus gallus)
REACT:R-DRE-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Danio rerio)
RHEA:28975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-asparagine(in) = H(+)(in) + L-asparagine(out)
RHEA:69755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzyl)malonyl-CoA + H(+) + O2 = (E)-2-aminocinnamoyl-CoA + CO2 + H2O2
REACT:R-HSA-8862137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B2 oxidises estradiol (E2) to estrone (E1) (Homo sapiens)
RHEA:57566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:23450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate => 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP
REACT:R-CFA-2465924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1LW binds 11cRAL (Canis familiaris)
REACT:R-DME-8853734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Drosophila melanogaster)
REACT:R-DRE-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Danio rerio)
REACT:R-HSA-2750181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-2 binds CASK (Homo sapiens)
RHEA:14839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + oxalate => glyoxylate + H2O + O2
RHEA:70376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + dodecanoyl-CoA => CoA + H(+) + N-dodecanoyl-3-oxosphinganine
GO:0004311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl pyrophosphate synthetase activity
GO:0004311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl pyrophosphate synthase activity
GO:0004311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl-diphosphate synthase activity
GO:0004311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl-PP synthetase activity
GO:0004311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesyltranstransferase activity
GO:0004311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity
GO:0004311	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	farnesyltransferase activity
RHEA:69542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-guanylylstreptomycin + diphosphate => GTP + streptomycin
RHEA:61316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => parkeol
RHEA:30688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate
RHEA:56770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + all-trans-adonixanthin + 3 H2O => 2 AH2 + all-trans-zeaxanthin + 2 O2
REACT:R-BTA-432164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Bos taurus)
REACT:R-XTR-3000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PLK1 (Xenopus tropicalis)
REACT:R-HSA-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Homo sapiens)
REACT:R-DRE-4332358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CaM and CAMK2 autophosphorylation (Danio rerio)
REACT:R-DME-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Drosophila melanogaster)
REACT:R-MMU-168921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)
REACT:R-BTA-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Bos taurus)
REACT:R-DDI-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Dictyostelium discoideum)
REACT:R-MMU-5654646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Mus musculus)
RHEA:61757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside A + UDP
REACT:R-CEL-416690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4A binds to PLXND1 (Caenorhabditis elegans)
RHEA:29649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + alpha-maltotetraose => alpha-maltopentaose + phosphate
REACT:R-MMU-201640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Mus musculus)
REACT:R-BTA-1295632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA2A dephosphorylates SPRY2 (Bos taurus)
GO:0035226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-cysteine ligase catalytic subunit binding
REACT:R-BTA-5690250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Bos taurus)
REACT:R-HSA-209063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Homo sapiens)
REACT:R-SSC-9611839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β3-agonists bind ADRB3 (Sus scrofa)
REACT:R-DRE-9728664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1R agonists (Danio rerio)
REACT:R-BTA-196857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK2 phosphorylates PanK (Bos taurus)
REACT:R-HSA-5655285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
RHEA:57879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(54) in tRNA <=> pseudouridine(54) in tRNA
RHEA:13358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + NAD(+) => 3-oxopropanoate + H(+) + NADH
GO:0045485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	omega-6 fatty acid desaturase activity
REACT:R-MMU-8854981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 in the RET complex is phosphorylated (Mus musculus)
REACT:R-HSA-9625699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1 and NR3C1 bind TRIM63 gene promoter (Homo sapiens)
REACT:R-XTR-5685994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Long-range resection of DNA DSBs by EXO1 or DNA2 (Xenopus tropicalis)
REACT:R-MMU-450063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Mus musculus)
REACT:R-DRE-446372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  PARVA with TESK1 (Danio rerio)
RHEA:13939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + NAD(+) + sulfite => 4-sulfobenzoate + NADH + O2
RHEA:25056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2
RHEA:35199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate(out) = (S,S)-tartrate(in)
REACT:R-MMU-1470012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus (Mus musculus)
REACT:R-DRE-198824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Danio rerio)
RHEA:20114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 1-phosphate => beta-D-glucose 6-phosphate
REACT:R-XTR-5693549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Xenopus tropicalis)
REACT:R-BTA-917811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3-like proteins reduce Fe3+ to Fe2+ (Bos taurus)
RHEA:13801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite
RHEA:13801	skos:prefLabel	"assimilatory sulfite reductase (NADPH)"
RHEA:13801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"assimilatory sulfite reductase (NADPH)"
RHEA:13801	skos:altLabel	"sulfite reductase (NADPH)"
REACT:R-HSA-1236947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Egress of internalized antigen to the cytosol via sec61 (Homo sapiens)
RHEA:39387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA = (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O
REACT:R-DME-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Drosophila melanogaster)
REACT:R-DDI-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Dictyostelium discoideum)
REACT:R-CFA-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Canis familiaris)
RHEA:48778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-2029475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of AA by iPLA2 upon FCGR activation (Sus scrofa)
REACT:R-CFA-159836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)
REACT:R-DRE-9661625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FVIII is secreted (Danio rerio)
RHEA:16468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + 2 Fe(III)-[cytochrome c553] <=> 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate
REACT:R-DRE-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Danio rerio)
REACT:R-DME-6800490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates PIDD1 (Drosophila melanogaster)
REACT:R-HSA-9020275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DHA to 17(S)-Hp-DHA (Homo sapiens)
REACT:R-SSC-8849157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Sus scrofa)
REACT:R-SPO-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Schizosaccharomyces pombe)
REACT:R-DRE-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Danio rerio)
RHEA:49523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 <=> an adenosine in mRNA + CO2 + formaldehyde + succinate
REACT:R-MMU-203130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OLR1 binds to oxidized LDL (Mus musculus)
RHEA:17401	skos:altLabel	"4-carboxy-2-oxohexenedioate hydratase"
RHEA:17401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate + H2O
RHEA:17401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-oxalmesaconate hydratase"
RHEA:17401	skos:prefLabel	"4-oxalmesaconate hydratase"
REACT:R-CEL-6803523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Caenorhabditis elegans)
RHEA:61770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + rebaudioside D + UDP => rebaudioside A + UDP-alpha-D-glucose
GO:0080048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-1-phosphate guanylyltransferase (GDP) activity
GO:0080048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP:glucose-1-phosphate guanyltransferase activity
GO:0080048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-D-glucose phosphorylase activity
RHEA:41372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:31142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH
REACT:R-HSA-430347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MigFilin associates with Filamin and F-actin (Homo sapiens)
REACT:R-GGA-936991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Gallus gallus)
RHEA:62215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:25580	skos:prefLabel	"L-fucose mutarotase"
RHEA:25580	skos:altLabel	"type-2 mutarotase"
RHEA:25580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-fucose = beta-L-fucose
RHEA:25580	skos:altLabel	"fucose 1-epimerase"
RHEA:25580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-fucose mutarotase"
REACT:R-DRE-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Danio rerio)
REACT:R-RNO-388529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholecystokinin receptors bind cholecystokinin (Rattus norvegicus)
REACT:R-RNO-9032798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK3 activates RAC1 (Rattus norvegicus)
REACT:R-DRE-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Danio rerio)
REACT:R-DRE-5649726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Danio rerio)
REACT:R-XTR-8855381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dephosphorylates ZAP70 (Xenopus tropicalis)
RHEA:38492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)
RHEA:25417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + A + 2 H2O
REACT:R-XTR-9681294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6R binds IL6R inhibitors (Xenopus tropicalis)
REACT:R-HSA-5669035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF11 binds TNFRSF11A, B (Homo sapiens)
RHEA:71239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)
GO:0102297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenate adenylyltransferase activity
REACT:R-BTA-1482907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Bos taurus)
RHEA:37698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA <=> 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
EC:3.2.2.16	skos:altLabel	"methylthioadenosine methylthioribohydrolase"
EC:3.2.2.16	skos:altLabel	"5'-methylthioadenosine nucleosidase"
EC:3.2.2.16	skos:altLabel	"MTA nucleosidase"
EC:3.2.2.16	skos:prefLabel	"methylthioadenosine nucleosidase"
EC:3.2.2.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylthioadenosine nucleosidase"
EC:3.2.2.16	skos:altLabel	"MeSAdo nucleosidase"
RHEA:19846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocardicin E + S-adenosyl-L-methionine => H(+) + isonocardicin A + S-methyl-5'-thioadenosine
REACT:R-DRE-372505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylcholine synaptic vesicle docking and priming (Danio rerio)
RHEA:35464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + NAD(+) => 5alpha-cholest-7-en-3-one + H(+) + NADH
REACT:R-SCE-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Saccharomyces cerevisiae)
RHEA:70863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + L-threonine(in) + Na(+)(out) = L-glutamine(in) + L-threonine(out) + Na(+)(in)
RHEA:21081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-methionine => diphosphate + phosphate + S-adenosyl-L-methionine
REACT:R-DDI-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Dictyostelium discoideum)
REACT:R-HSA-2562541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR4-induced ripoptosome assembly (Homo sapiens)
REACT:R-CEL-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Caenorhabditis elegans)
RHEA:23879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoaphin aglucone <=> H2O + xanthoaphin
RHEA:13250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH
REACT:R-DRE-904830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)
RHEA:48041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + H2O => globoside Gb3Cer + N-acetyl-beta-D-galactosamine
REACT:R-BTA-188979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Bos taurus)
RHEA:71885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide => GMP + NAD(+)
RHEA:46847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
GO:0004497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monooxygenase activity
GO:0004497	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylase activity
RHEA:10608	skos:altLabel	"CA4H"
RHEA:10608	skos:altLabel	"cinnamic acid 4-hydroxylase"
RHEA:10608	skos:altLabel	"cinnamic acid 4-monooxygenase"
RHEA:10608	skos:altLabel	"CYP73A1"
RHEA:10608	skos:prefLabel	"trans-cinnamate 4-monooxygenase"
RHEA:10608	skos:altLabel	"cinnamate 4-monooxygenase"
RHEA:10608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] = (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10608	skos:altLabel	"cinnamate 4-hydroxylase"
RHEA:10608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-cinnamate 4-monooxygenase"
REACT:R-DRE-5654159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds PLCG1 (Danio rerio)
RHEA:66437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pentan-3-one => H(+) + NADPH + pent-1-en-3-one
GO:0050343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-2-enoyl-CoA reductase (NAD(+))"
GO:0050343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2-enoyl-CoA reductase (NAD+) activity
GO:0050343	skos:prefLabel	"trans-2-enoyl-CoA reductase (NAD(+))"
GO:0050343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH
GO:0050343	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:NAD+ trans-2-oxidoreductase activity
RHEA:39674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O
REACT:R-RNO-5654628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS3 (Rattus norvegicus)
RHEA:44376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)
GO:0043515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinetochore binding
REACT:R-BTA-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Bos taurus)
REACT:R-MMU-174438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate on the C-strand (Mus musculus)
GO:0062078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tuberin-hamartin complex binding
GO:0062078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSC1-TSC2 complex binding
GO:0062078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tuberin sclerosis complex binding
REACT:R-BTA-2060328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS1 (Bos taurus)
REACT:R-XTR-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Xenopus tropicalis)
RHEA:15236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[cytochrome c] + H2O + nitric oxide <=> Fe(II)-[cytochrome c] + 2 H(+) + nitrite
REACT:R-RNO-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Rattus norvegicus)
RHEA:32765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate => (3R)-3-methyl-D-ornithine + ATP + L-lysine
RHEA:56049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein + UDP-alpha-D-glucose => daidzein 7-O-beta-D-glucoside + UDP
REACT:R-BTA-444654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled bile acid receptor binds lithocholic acid (Bos taurus)
RHEA:49258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein]
REACT:R-MMU-8851842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUC20 binds MET and inhibits GRB2 binding (Mus musculus)
REACT:R-MMU-9024997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Mus musculus)
RHEA:51691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NAD(+) <=> H(+) + keto-L-tagatose + NADH
RHEA:41898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H(+) + NADPH
REACT:R-HSA-936952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Homo sapiens)
RHEA:50173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine
RHEA:18284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + succinate <=> fumarate + H(+) + NADH
REACT:R-DME-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Drosophila melanogaster)
REACT:R-XTR-430096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds filamin (Xenopus tropicalis)
RHEA:28248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4-phosphopantoate + ADP + H(+) => (R)-pantoate + ATP
RHEA:29820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-isoleucine(out) => ADP + H(+) + L-isoleucine(in) + phosphate
RHEA:53889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + TDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + TDP
RHEA:65363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
GO:0036140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-asparagine 3-dioxygenase activity
GO:0036140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-asparagine 3-dioxygenase activity
GO:0036140	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hypoxia-inducible factor-asparagine oxygenase activity
REACT:R-RNO-9698170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Rattus norvegicus)
RHEA:61504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin + UDP-alpha-D-glucose = pelargonidin 3-O-beta-D-glucoside + UDP
RHEA:22517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + taurocyamine => ADP + H(+) + N-phosphotaurocyamine
REACT:R-HSA-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)
RHEA:69218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH => (omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+)
REACT:R-DRE-383363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 2 (NK2) binds to nuerokinin A (Danio rerio)
REACT:R-SSC-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Sus scrofa)
RHEA:72538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + vanillin <=> 2 H(+) + NADPH + vanillate
REACT:R-SSC-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Sus scrofa)
REACT:R-CEL-9704248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM4 binds CHRM4 antagonists (Caenorhabditis elegans)
RHEA:50335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-2465938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates atROL taken up by Muller cells (Rattus norvegicus)
REACT:R-RNO-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Rattus norvegicus)
REACT:R-MMU-5660663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 cleaves IL1B precursor (Mus musculus)
RHEA:51192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH
REACT:R-CFA-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Canis familiaris)
REACT:R-RNO-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Rattus norvegicus)
REACT:R-RNO-381503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP6 binds IGF forming IGF:IGFBP6 (Rattus norvegicus)
REACT:R-XTR-8987063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Xenopus tropicalis)
RHEA:42093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-omegaC7-CoA + O2 = asc-omegaDeltaC7-CoA + H2O2
REACT:R-CFA-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
RHEA:32640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + succinate => hydrogen sulfide + O-succinyl-L-serine
GO:0004449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate dehydrogenase (NAD) activity
GO:0004449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD dependent isocitrate dehydrogenase activity
GO:0004449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate dehydrogenase (NAD+) activity
GO:0004449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD isocitric dehydrogenase activity
GO:0004449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide adenine dinucleotide isocitrate dehydrogenase activity
GO:0004449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate:NAD+ oxidoreductase (decarboxylating)
GO:0004449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-specific isocitrate dehydrogenase activity
GO:0004449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-linked isocitrate dehydrogenase activity
GO:0004449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD isocitrate dehydrogenase activity
REACT:R-DRE-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Danio rerio)
REACT:R-SPO-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Schizosaccharomyces pombe)
REACT:R-RNO-8851298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR143 binds L-Dopa (Rattus norvegicus)
REACT:R-SCE-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Saccharomyces cerevisiae)
GO:0050179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylserine aldolase activity
GO:0050179	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)
GO:0050179	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threo-3-phenylserine benzaldehyde-lyase activity
REACT:R-SCE-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Saccharomyces cerevisiae)
RHEA:15844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + NADP(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
REACT:R-PFA-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Plasmodium falciparum)
RHEA:63563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin I + H2O <=> angiotensin II + L-histidyl-L-leucine
REACT:R-CFA-9020282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Canis familiaris)
GO:0008294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium- and calmodulin-responsive adenylate cyclase activity
GO:0008294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium/calmodulin-responsive adenylate cyclase activity
GO:0008294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Homo sapiens)
GO:0008294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium- and calmodulin-responsive adenylyl cyclase activity
GO:0008294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP (Homo sapiens)
REACT:R-MMU-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Mus musculus)
REACT:R-MMU-201821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Mus musculus)
REACT:R-CFA-8853737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Canis familiaris)
REACT:R-GGA-5654612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)
REACT:R-XTR-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Xenopus tropicalis)
RHEA:41393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)
REACT:R-DRE-6782004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the pre-incision complex in TC-NER (Danio rerio)
REACT:R-HSA-9636564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SapM binds RAB7A (Homo sapiens)
RHEA:33675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) = H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2
REACT:R-RNO-5218811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO binds CRK (Rattus norvegicus)
REACT:R-CEL-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Caenorhabditis elegans)
RHEA:12254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferol + D-glucose => 4-O-(beta-D-glucosyl)-trans-coniferol + H2O
GO:0140619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA strand exchange activator activity
REACT:R-BTA-5649681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL2 cleaves 5-OHU from damaged DNA (Bos taurus)
REACT:R-HSA-381086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of PERK:BiP Heterodimer (Homo sapiens)
REACT:R-GGA-2029460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates LIMK1 (Gallus gallus)
REACT:R-HSA-5210932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANTXR2-bound pagA(197-794) forms oligomers (Homo sapiens)
RHEA:29910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-(1'-rac-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate
REACT:R-CEL-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Caenorhabditis elegans)
RHEA:71162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-serine(out) + Na(+)(out) <=> H(+)(out) + L-serine(in) + Na(+)(in)
RHEA:59297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylglycine + 2 L-ascorbate + O2 => an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical
REACT:R-CFA-2408524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Canis familiaris)
RHEA:10474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanoate + pyruvate => (2R,3S)-2,3-dimethylmalate
REACT:R-RNO-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)
RHEA:12086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + H(+) + NADH => D-mannitol + NAD(+)
REACT:R-HSA-6789218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypochlorous acid (HOCl) reacts with unsaturated lipid to form lipid chlorohydrins (Homo sapiens)
REACT:R-BTA-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Bos taurus)
RHEA:51440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 = (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
RHEA:34447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-beta-L-talose + NAD(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH
REACT:R-DME-5419281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRRF binds 55S ribosome:mRNA:tRNA (Drosophila melanogaster)
REACT:R-SCE-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Saccharomyces cerevisiae)
RHEA:60442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + methanol => H2O + methyl acetate
REACT:R-DME-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Drosophila melanogaster)
REACT:R-CFA-212263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 trimethylates histone H3 at lysine-27 (Canis familiaris)
RHEA:19737	skos:prefLabel	"gamma-glutamyl-gamma-aminobutyrate hydrolase"
RHEA:19737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate
RHEA:19737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-glutamyl-gamma-aminobutyrate hydrolase"
RHEA:19737	skos:altLabel	"gamma-glutamyl-GABA hydrolase"
REACT:R-XTR-451895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RG binds JAK3 (Xenopus tropicalis)
REACT:R-DME-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Drosophila melanogaster)
RHEA:13069	skos:prefLabel	"ethanolamine kinase"
RHEA:13069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethanolamine kinase"
RHEA:13069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + ethanolamine = ADP + H(+) + phosphoethanolamine
REACT:R-HSA-9026894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK2 (Homo sapiens)
REACT:R-HSA-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)
RHEA:12670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate
RHEA:53880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate + H(+)
RHEA:53880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha,alpha-trehalose-phosphate synthase (ADP-forming)"
RHEA:53880	skos:altLabel	"ADP-glucose--glucose-phosphate glucosyltransferase"
RHEA:53880	skos:prefLabel	"alpha,alpha-trehalose-phosphate synthase (ADP-forming)"
GO:0102693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:kinetin 7-N-glucosyltransferase activity
RHEA:17670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)
REACT:R-BTA-209532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR C-terminal fragment enters endosomes (Bos taurus)
RHEA:37693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA
RHEA:25846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carvone + H(+) + NADH => (1S,5R)-carveol + NAD(+)
RHEA:27644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + alpha-D-ribose 1-phosphate => adenosine + phosphate
REACT:R-CFA-373750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:ErbB2 (Canis familiaris)
GO:0000993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II core binding
GO:0000993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II complex binding
GO:0000993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNAP II core binding
GO:0009041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridylate kinase activity
REACT:R-HSA-1855220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 transports from the nucleus to the cytosol (Homo sapiens)
REACT:R-BTA-5682709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI4 binds ADAM22,23,11 (Bos taurus)
REACT:R-CFA-2076508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS2ST1 sulfates IdoA at C2 in heparan sulfate (Canis familiaris)
REACT:R-XTR-9691621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5 binds C5 inhibitors (Xenopus tropicalis)
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine-phosphate oxidase activity
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine phosphate oxidase activity
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine 5'-phosphate oxidase activity
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PMP oxidase activity
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxaminephosphate oxidase deaminating
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxine (pyridoxamine) 5'-phosphate oxidase activity
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxine (pyridoxamine)phosphate oxidase activity
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PdxH
GO:0004733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal 5'-phosphate synthase activity
REACT:R-HSA-9701903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK-, STAT3- and MECP2-dependent STAT5A gene repression (Homo sapiens)
REACT:R-RNO-6788556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to NDUFV1, V2 (Rattus norvegicus)
REACT:R-BTA-5682863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF168 binds DNA DSBs (Bos taurus)
RHEA:43352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)
RHEA:27560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 3 diphosphate
RHEA:72550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + taurocholate(out) <=> 2-oxoglutarate(out) + taurocholate(in)
RHEA:49903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine-1,6-dicarboxylate + O2 <=> H2O2 + phenazine-1,6-dicarboxylate
RHEA:49574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrin III + Fe(2+) => Fe-coproporphyrin III + 2 H(+)
REACT:R-HSA-6797268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HMOX1 (Homo sapiens)
RHEA:37565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-MMU-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Mus musculus)
REACT:R-RNO-158722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Rattus norvegicus)
REACT:R-CFA-449087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD4 binds Interleukin-16 (Canis familiaris)
RHEA:50806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin J2-S-(R)-glutathione => glutathione + prostaglandin J2
REACT:R-SSC-3965450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits PFN1 (Sus scrofa)
RHEA:60851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]
RHEA:66202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-pentenoyl-CoA + H2O2 => O2 + pentanoyl-CoA
GO:0072587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity
REACT:R-MMU-75126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Mus musculus)
REACT:R-SSC-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Sus scrofa)
RHEA:55833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-1679589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal full-length TLR9 (Canis familiaris)
REACT:R-SSC-9709360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 reduces MetHb (Sus scrofa)
REACT:R-SSC-2395302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysino-5-ketonorleucine cross-links (Sus scrofa)
RHEA:59185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetylphloroglucinol + H2O => 2-acetylphloroglucinol + acetate
RHEA:19297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-histidine = ADP + carnosine + H(+) + phosphate
RHEA:68674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate
REACT:R-CFA-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Canis familiaris)
REACT:R-DRE-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Danio rerio)
GO:0034840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxymenthone dehydrogenase activity
REACT:R-CFA-8941701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Canis familiaris)
RHEA:64842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + phenethyl benzoate => 2-phenylethanol + benzoyl-CoA
REACT:R-HSA-5334854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAR:RXR binds SUMO-CRABP2:atRA (Homo sapiens)
REACT:R-DRE-352379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Danio rerio)
REACT:R-SSC-8851352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR8 binds CCL1 (Sus scrofa)
RHEA:53003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:15416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate <=> H2O + oxaloacetate
RHEA:18494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + glycine => CoA + H(+) + N-benzoylglycine
RHEA:54298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein] => GTP + L-tyrosyl-[protein]
EC:4.4.1.8	skos:altLabel	"cysteine lyase"
EC:4.4.1.8	skos:altLabel	"beta-cystathionase"
EC:4.4.1.8	skos:prefLabel	"cystathionine beta-lyase"
EC:4.4.1.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cystathionine beta-lyase"
EC:4.4.1.8	skos:altLabel	"beta C-S lyase"
EC:4.4.1.8	skos:altLabel	"cystine lyase"
REACT:R-XTR-5607721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NIK (Xenopus tropicalis)
RHEA:29272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + H(+) + trimethylamine N-oxide => a menaquinone + H2O + trimethylamine
REACT:R-RNO-2161795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Rattus norvegicus)
REACT:R-XTR-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Xenopus tropicalis)
REACT:R-XTR-3132759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds RCbl (Xenopus tropicalis)
RHEA:32311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine N-monooxygenase"
RHEA:32311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:32311	skos:altLabel	"tyrosine N-hydroxylase"
RHEA:32311	skos:prefLabel	"tyrosine N-monooxygenase"
RHEA:32311	skos:altLabel	"CYP79A1"
REACT:R-DME-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Drosophila melanogaster)
REACT:R-RNO-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Rattus norvegicus)
REACT:R-RNO-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Rattus norvegicus)
REACT:R-GGA-9014295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GAPs stimulate RAC2 GTPase activity (Gallus gallus)
REACT:R-BTA-1482868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Bos taurus)
REACT:R-HSA-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Homo sapiens)
REACT:R-SPO-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Schizosaccharomyces pombe)
RHEA:55553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine
REACT:R-DRE-70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer oxidises LACT to PYR (Danio rerio)
REACT:R-RNO-8852280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds microtubule lattice in interphase cells (Rattus norvegicus)
REACT:R-GGA-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Gallus gallus)
REACT:R-SPO-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Schizosaccharomyces pombe)
EC:3.4.22.57	skos:altLabel	"ICErelII"
EC:3.4.22.57	skos:altLabel	"CASP-4"
EC:3.4.22.57	skos:prefLabel	"caspase-4"
EC:3.4.22.57	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-4"
EC:3.4.22.57	skos:altLabel	"Ich-2"
EC:3.4.22.57	skos:altLabel	"ICErel-II"
REACT:R-DME-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Drosophila melanogaster)
REACT:R-MMU-8851679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR183 binds 7alpha,25-dihydroxycholesterol (Mus musculus)
GO:0018829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity
GO:0018829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDD dehydrochlorinase activity
REACT:R-BTA-5674019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds KSR1:MARK3 (Bos taurus)
REACT:R-BTA-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Bos taurus)
EC:4.1.1.96	skos:altLabel	"carboxyspermidine decarboxylase"
EC:4.1.1.96	skos:prefLabel	"carboxynorspermidine decarboxylase"
EC:4.1.1.96	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxynorspermidine decarboxylase"
REACT:R-SCE-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Saccharomyces cerevisiae)
REACT:R-MMU-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)
REACT:R-HSA-199935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates CREB (Homo sapiens)
RHEA:58679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + rifamycin SV <=> H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide
RHEA:65060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH
REACT:R-MMU-5654423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Mus musculus)
REACT:R-RNO-2730851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
RHEA:18051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + N-acetyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-acetyl-L-ornithine
RHEA:65893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate => H2O + xanthurenate
REACT:R-HSA-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
GO:0031705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bombesin receptor binding
GO:0031705	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bombesin receptor ligand
RHEA:43480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-SSC-2213244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides (Sus scrofa)
REACT:R-CEL-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Caenorhabditis elegans)
GO:0106281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NAD(+) = 7-oxolithocholate + H(+) + NADH
GO:0106281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
REACT:R-DME-1234177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
REACT:R-MMU-8937744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-7Y-RUNX1 (Mus musculus)
RHEA:20923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorophenol + H(+) + NADPH + O2 <=> 3,5-dichlorocatechol + H2O + NADP(+)
RHEA:52145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphonopyruvate + acetyl-CoA + H2O => (R)-2-(phosphonomethyl)malate + CoA + H(+)
REACT:R-MMU-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Mus musculus)
REACT:R-DRE-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Danio rerio)
RHEA:11717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoamide of a dicarboxylate + H2O => a dicarboxylate + NH4(+)
REACT:R-CFA-6783552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM binds LIFR:JAKs,OSMR:JAKs (Canis familiaris)
RHEA:44191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-BTA-5669250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates FLNA (Bos taurus)
REACT:R-XTR-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Xenopus tropicalis)
RHEA:35074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol(in) <=> 4-methylphenol(out)
REACT:R-HSA-5675947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF18 binds TNFRSF18 (Homo sapiens)
RHEA:45093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octanoylsphing-4-enine => octanoate + sphing-4-enine
GO:0035662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Toll-like receptor 4 binding
GO:0035662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR4 binding
RHEA:33422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate
RHEA:19643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + AMP + diphosphate => (E)-4-coumarate + ATP + CoA
RHEA:10838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylsulochrin + NADP(+) => NADPH + O2 + questin
RHEA:46716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine
RHEA:21400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxoglutarate dehydrogenase (NADP(+))"
RHEA:21400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CoA + NADP(+) = CO2 + NADPH + succinyl-CoA
RHEA:21400	skos:prefLabel	"oxoglutarate dehydrogenase (NADP(+))"
REACT:R-HSA-114254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS binds to APAF1 (Homo sapiens)
RHEA:11599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + orotidine 5'-phosphate <=> CO2 + UMP
REACT:R-BTA-2179274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD3 phosphorylated in the linker region (Bos taurus)
REACT:R-CFA-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)
RHEA:71762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + heptanedioate(in) <=> 2-oxoglutarate(in) + heptanedioate(out)
GO:0051002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase activity, forming nitrogen-metal bonds
GO:0051002	skos:prefLabel	"Forming nitrogen-metal bonds"
GO:0051002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming nitrogen-metal bonds"
RHEA:48322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside Fuc-GA1 + GDP + H(+) => ganglioside GA1 + GDP-beta-L-fucose
REACT:R-HSA-447130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-23 binds interleukin-23 receptor (Homo sapiens)
REACT:R-RNO-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Rattus norvegicus)
RHEA:51697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethylxanthohumol + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + xanthohumol
REACT:R-GGA-981832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMUR2 binds neuromedin-S (Gallus gallus)
REACT:R-SSC-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Sus scrofa)
REACT:R-XTR-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Xenopus tropicalis)
RHEA:16124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O <=> 3-(carbamoylamino)propanoate + H(+)
RHEA:17089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate
REACT:R-SSC-9657619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Sus scrofa)
REACT:R-CEL-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Caenorhabditis elegans)
REACT:R-XTR-5638332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)
REACT:R-HSA-9006122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDNF gene transcription (Homo sapiens)
RHEA:64717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propanal => acrolein + H(+) + NADPH
REACT:R-CEL-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Caenorhabditis elegans)
GO:0034336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA chaperone
GO:0034336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded RNA binding
REACT:R-SPO-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Schizosaccharomyces pombe)
REACT:R-BTA-8868230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
REACT:R-RNO-71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Rattus norvegicus)
REACT:R-MMU-9647680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP1 cleaves GSDMD (Mus musculus)
REACT:R-RNO-2186643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEN1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
REACT:R-BTA-180047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates DARPP-32 on Thr75 (Bos taurus)
REACT:R-DME-351963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A18 transports Gly from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-HSA-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Homo sapiens)
RHEA:37953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
GO:0060961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase D inhibitor activity
REACT:R-MMU-9021068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs bind CAVs (Mus musculus)
RHEA:69734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + phenylacetyl-AMP <=> AMP + H(+) + phenylacetyl-CoA
RHEA:64931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dADP + H2O <=> dAMP + H(+) + phosphate
REACT:R-GGA-5610742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI1 (Gallus gallus)
REACT:R-SCE-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Saccharomyces cerevisiae)
REACT:R-CFA-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Canis familiaris)
REACT:R-RNO-416985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to synapse (Rattus norvegicus)
REACT:R-XTR-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Xenopus tropicalis)
RHEA:52793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + 2 H(+) => Mg(2+) + pheophorbide a
RHEA:16125	skos:altLabel	"D-fructokinase"
RHEA:16125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+)
RHEA:16125	skos:prefLabel	"fructokinase"
RHEA:16125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructokinase"
RHEA:71643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide
RHEA:59311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactono-1,5-lactone + H2O <=> D-galactonate + H(+)
REACT:R-RNO-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Rattus norvegicus)
REACT:R-HSA-1461982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-defensin dimers multimerize to form a pore complex (Homo sapiens)
RHEA:11882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxypseudooxynicotine + H2O2 => (S)-6-hydroxynicotine + H2O + O2
REACT:R-MMU-1169404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ISG15 from E1 to E2 (UBCH8) (Mus musculus)
RHEA:14603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanamide + CO2 + H2O => L-lysine + O2
REACT:R-HSA-6782234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recovery of RNA synthesis after TC-NER (Homo sapiens)
REACT:R-MMU-5668417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Mus musculus)
GO:0004397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidine ammonia-lyase (urocanate-forming)
GO:0004397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidase activity
GO:0004397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidine ammonia-lyase activity
GO:0004397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidinase activity
GO:0004397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine ammonia-lyase activity
GO:0004397	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine alpha-deaminase activity
GO:0016438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity
GO:0016438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-queuosine beta-mannosyltransferase activity
REACT:R-DRE-350058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL NCOR corepressor complex (Danio rerio)
REACT:R-SPO-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Schizosaccharomyces pombe)
REACT:R-SSC-445064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by VAV2 (Sus scrofa)
REACT:R-DDI-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Dictyostelium discoideum)
RHEA:29124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(out) + ubiquinol-8(in) => H2O(out) + nitrite(out) + ubiquinone-8(in)
RHEA:29717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + glycolaldehyde + 2 H(+) + H2O + sulfite => 2-hydroxyethane-1-sulfonate + FMNH2 + O2
RHEA:72646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine
REACT:R-XTR-6797803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds SLITRK1-6 (Xenopus tropicalis)
RHEA:18302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NH4(+) + XMP => AMP + diphosphate + GMP + 2 H(+)
RHEA:39652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)
RHEA:58104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
RHEA:43783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-912505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synapsis (Homo sapiens)
REACT:R-DME-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Drosophila melanogaster)
RHEA:52189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O
REACT:R-CFA-2395818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)
REACT:R-XTR-3000434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Xenopus tropicalis)
REACT:R-MMU-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Mus musculus)
REACT:R-MMU-5669024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD70 binds CD27 (Mus musculus)
REACT:R-CEL-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Caenorhabditis elegans)
REACT:R-MMU-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)
REACT:R-RNO-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Rattus norvegicus)
RHEA:55110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxynonanoyl-[ACP] + NADP(+) => 3-oxononanoyl-[ACP] + H(+) + NADPH
REACT:R-DME-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)
RHEA:19360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-proline betaine + NADPH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NADP(+)
REACT:R-SSC-177939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)
REACT:R-MMU-158744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Mus musculus)
RHEA:37732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
GO:0102267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-dihydrouridine20b synthase activity
REACT:R-BTA-5676593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Bos taurus)
REACT:R-HSA-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)
REACT:R-BTA-549304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal clearance of organic cations (Bos taurus)
RHEA:31514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + H2O <=> chenodeoxycholate + CoA + H(+)
REACT:R-CFA-8875576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)
EC:6.2.1.55	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"E1 SAMP-activating enzyme"
EC:6.2.1.55	skos:altLabel	"SAMP-activating enzyme E1"
EC:6.2.1.55	skos:prefLabel	"E1 SAMP-activating enzyme"
RHEA:69419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + thiocyanate <=> H2O + hypothiocyanous acid
RHEA:35582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 <=> anthocyanin A11 + D-glucose
REACT:R-MMU-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Mus musculus)
REACT:R-DME-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Drosophila melanogaster)
REACT:R-RNO-1433454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GAB2 by SFKs (Rattus norvegicus)
RHEA:67546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine => (9Z)-tetradecenoyl-CoA + H2O
RHEA:30302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a methylated nucleobase within DNA + O2 <=> a nucleobase within DNA + CO2 + formaldehyde + succinate
GO:0102880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobazzanene synthase activity
REACT:R-DME-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Drosophila melanogaster)
RHEA:70593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA
REACT:R-CFA-5693574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Canis familiaris)
RHEA:42077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + acetyl-CoA => 2-hydroxyglutaryl-CoA + acetate
RHEA:55432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:55432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnosic acid synthase"
RHEA:55432	skos:altLabel	"CYP76AK7"
RHEA:55432	skos:altLabel	"CYP76AK6"
RHEA:55432	skos:altLabel	"CYP76AK8"
RHEA:55432	skos:prefLabel	"carnosic acid synthase"
RHEA:14763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-serine
RHEA:32354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 S-adenosyl-L-methionine + tricetin <=> 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-RNO-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Rattus norvegicus)
RHEA:49967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine + O2 <=> H2O2 + phenazine
REACT:R-HSA-5433067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Homo sapiens)
REACT:R-DME-8934735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 arginine-methylates RUNX1 (Drosophila melanogaster)
RHEA:45515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]
REACT:R-DDI-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Dictyostelium discoideum)
RHEA:26417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary aliphatic amine + H2O + O2 <=> a primary amine + an aldehyde + H2O2
RHEA:29391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O = diphosphate + GMP + H(+)
RHEA:23571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-[ACP] <=> (3Z)-decenoyl-[ACP]
REACT:R-PFA-5685319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex formation (Plasmodium falciparum)
REACT:R-MMU-8864307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Mus musculus)
GO:0043274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase binding
REACT:R-DME-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Drosophila melanogaster)
REACT:R-XTR-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Xenopus tropicalis)
RHEA:48744	skos:prefLabel	"(-)-deoxypodophyllotoxin synthase"
RHEA:48744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-deoxypodophyllotoxin synthase"
RHEA:48744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + CO2 + H2O + succinate
REACT:R-DRE-2730840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Danio rerio)
REACT:R-MMU-2160935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 ubiquitinates RHOA (Mus musculus)
RHEA:25673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + UDP-alpha-D-galactose <=> H(+) + loliose + UDP
RHEA:22942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(omega)-phospho-L-arginine => ATP + L-arginine
REACT:R-MMU-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Mus musculus)
RHEA:13571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP => ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine
RHEA:54045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => 7-epi-alpha-eudesmol + diphosphate
REACT:R-RNO-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Rattus norvegicus)
REACT:R-HSA-6789615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
REACT:R-CEL-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Caenorhabditis elegans)
REACT:R-BTA-4332356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK2 binds MAP3K7 (Bos taurus)
RHEA:38950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-1793209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses Chondroitin chains (Canis familiaris)
REACT:R-MMU-2395965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)
REACT:R-CFA-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Canis familiaris)
RHEA:33807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2
RHEA:52351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-DDI-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)
RHEA:11656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-proline--[L-prolyl-carrier protein] ligase"
RHEA:11656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-proline = AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]
RHEA:11656	skos:prefLabel	"L-proline--[L-prolyl-carrier protein] ligase"
REACT:R-DRE-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)
REACT:R-XTR-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Xenopus tropicalis)
REACT:R-RNO-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Rattus norvegicus)
RHEA:51092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:20426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + ATP + hydrogencarbonate => (S)-oxalosuccinate + ADP + H(+) + phosphate
REACT:R-MMU-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Mus musculus)
REACT:R-DRE-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Danio rerio)
GO:0099621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ara4FN transferase activity
GO:0099621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyl phosphate-L-Ara4FN transferase activity
GO:0099621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyl-phosphate Ara4FN transferase activity
GO:0099621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity
REACT:R-DME-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Drosophila melanogaster)
REACT:R-XTR-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)
REACT:R-SSC-975142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Sus scrofa)
RHEA:23209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + trans-glutaconate => (2E)-glutaconyl-CoA + acetate
RHEA:22751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-4-methyl-2-oxoglutarate <=> 2 pyruvate
RHEA:50521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]
RHEA:14798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + ATP => 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)
RHEA:41377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)
REACT:R-CFA-5666104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Canis familiaris)
REACT:R-HSA-5624126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome bind ciliary cargo (Homo sapiens)
RHEA:45331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin <=> 7,8-dihydromonapterin
RHEA:37209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-CEL-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)
REACT:R-GGA-391939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP receptor can bind thromboxane (Gallus gallus)
REACT:R-DRE-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Danio rerio)
REACT:R-HSA-74742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 (Homo sapiens)
REACT:R-DDI-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Dictyostelium discoideum)
REACT:R-HSA-9011985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Homo sapiens)
REACT:R-HSA-1181152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of NODAL proprotein (Homo sapiens)
RHEA:58553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate II + H2O => (16R)-deshydroxymethyl-stemmadenine + formate
REACT:R-XTR-4085033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Xenopus tropicalis)
REACT:R-BTA-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Bos taurus)
REACT:R-GGA-114256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS:APAF1 binds procaspase-9 (Gallus gallus)
RHEA:29955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + thymidine(in) = H(+)(out) + thymidine(out)
RHEA:56414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine
REACT:R-DME-8874718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA binds alpha-TOH (Drosophila melanogaster)
REACT:R-GGA-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Gallus gallus)
REACT:R-RNO-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Rattus norvegicus)
REACT:R-DRE-445753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Danio rerio)
RHEA:50101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + taurine => CoA + H(+) + N-dodecanoyl-taurine
RHEA:72708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose(in) + GMP(out) => GDP-beta-L-fucose(out) + GMP(in)
REACT:R-CEL-8874080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates PTK2 (Caenorhabditis elegans)
REACT:R-DDI-9020282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)
REACT:R-MMU-4641260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL1 is degraded by the proteasome (Mus musculus)
RHEA:19977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate
RHEA:19977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine-ester sulfotransferase"
RHEA:19977	skos:prefLabel	"tyrosine-ester sulfotransferase"
RHEA:45856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA
RHEA:35695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-versiconol acetate + NADP(+) = (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH
RHEA:52200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aci-nitro-2-(phenyl)ethane + glutathione = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O
REACT:R-DDI-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)
REACT:R-DRE-5668629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Danio rerio)
REACT:R-RNO-158781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Rattus norvegicus)
RHEA:24105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA => 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine
REACT:R-CFA-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Canis familiaris)
RHEA:46923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) <=> CO2 + styrene
REACT:R-HSA-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Homo sapiens)
REACT:R-RNO-1222376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide from oxygen (Rattus norvegicus)
REACT:R-DDI-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Dictyostelium discoideum)
REACT:R-MMU-5607720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p100:RELB binds active NIK:p-IKKA dimer (Mus musculus)
REACT:R-MMU-5578777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMPK phosphorylates PLN (Mus musculus)
REACT:R-MMU-156526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Mus musculus)
REACT:R-RNO-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Rattus norvegicus)
REACT:R-BTA-9607301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2 binds SOS1 (Bos taurus)
REACT:R-CEL-71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)
REACT:R-XTR-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Xenopus tropicalis)
RHEA:37133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate
REACT:R-HSA-200421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of cytosolic AMPK by phosphorylation (Homo sapiens)
REACT:R-BTA-9603302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (peptide) binds IIa (Bos taurus)
REACT:R-DRE-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Danio rerio)
REACT:R-SSC-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Sus scrofa)
RHEA:23845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + sedoheptulose => ADP + D-sedoheptulose 7-phosphate + H(+)
RHEA:65776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:72048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline => AH2 + fusahexin + 6 H2O
EC:1.14.14.90	skos:altLabel	"CYP Ge-3"
EC:1.14.14.90	skos:prefLabel	"isoflavone 2'-hydroxylase"
EC:1.14.14.90	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoflavone 2'-hydroxylase"
EC:1.14.14.90	skos:altLabel	"CYP81E1"
EC:1.14.14.90	skos:altLabel	"isoflavone 2'-monooxygenase"
REACT:R-SSC-210277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-1 (Sus scrofa)
RHEA:41184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
REACT:R-HSA-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Homo sapiens)
REACT:R-XTR-201630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Acinus (Xenopus tropicalis)
RHEA:31503	skos:prefLabel	"xanthan pyruvate transferase"
RHEA:31503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate = 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate
RHEA:31503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xanthan pyruvate transferase"
REACT:R-CFA-9024881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Canis familiaris)
RHEA:19820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH
REACT:R-HSA-2064932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds RUNX2 (Homo sapiens)
REACT:R-DRE-211186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DFF45 (224) by caspase-3 (Danio rerio)
RHEA:62634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + glutathione disulfide + H2O => a hydroperoxide + 2 glutathione
REACT:R-HSA-5637686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
RHEA:22603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-9-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate
REACT:R-CEL-426223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cation influx mediated by TRPC3/6/7 (Caenorhabditis elegans)
RHEA:59160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]
RHEA:59160	skos:prefLabel	"long-chain fatty acid adenylase/transferase FadD26"
RHEA:59160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain fatty acid adenylase/transferase FadD26"
RHEA:59160	skos:altLabel	"FadD26"
REACT:R-RNO-8847977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRK phosphorylates PTEN (Rattus norvegicus)
REACT:R-CFA-3000120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLIF binds RCbl (Canis familiaris)
GO:0052742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol kinase activity
REACT:R-MMU-193385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of choloyl-CoA to cholate and CoASH (Mus musculus)
REACT:R-RNO-77340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Rattus norvegicus)
REACT:R-SSC-6803761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Sus scrofa)
REACT:R-DRE-183130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Danio rerio)
RHEA:56996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-apiose = apulose
RHEA:56996	skos:prefLabel	"D-apiose isomerase"
RHEA:56996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-apiose isomerase"
REACT:R-HSA-193981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 oxidises 17HPROG (Homo sapiens)
REACT:R-BTA-5661117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Bos taurus)
REACT:R-MMU-9678766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 binds CYP3A4 inhibitors (Mus musculus)
RHEA:40595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanedioyl-CoA + H2O = CoA + dodecanedioate + H(+)
REACT:R-SSC-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Sus scrofa)
REACT:R-XTR-432295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI binds Fyn and Lyn (Xenopus tropicalis)
RHEA:57698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)inamide-[corrinoid adenosyltransferase]
RHEA:29306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + succinate(in) <=> 2 H(+)(out) + succinate(out)
RHEA:36749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose
REACT:R-DRE-374207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled estrogen receptor 1 binds estrogen non-classically (Danio rerio)
REACT:R-DRE-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Danio rerio)
RHEA:45138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-phosphate + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate
RHEA:47260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:12074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O
REACT:R-GGA-74746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y427-SHC1 (Gallus gallus)
RHEA:34404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-10'-apo-beta-carotenal + 2 O2 => (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone
REACT:R-CEL-75079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC C complex (Caenorhabditis elegans)
REACT:R-XTR-8875661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA3 associates with activated MET receptor (Xenopus tropicalis)
RHEA:64274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + L-alanine => benzylamine + pyruvate
GO:0106358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH
GO:0106358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-1-phosphate dehydrogenase [NADP+] activity
REACT:R-HSA-9702601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	midostaurin-resistant FLT3 mutants don't bind midostaurin (Homo sapiens)
RHEA:30647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1L-myo-inositol 1-phosphate cytidylyltransferase"
RHEA:30647	skos:altLabel	"L-myo-inositol-1-phosphate cytidylyltransferase"
RHEA:30647	skos:prefLabel	"1L-myo-inositol 1-phosphate cytidylyltransferase"
RHEA:30647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate
RHEA:30647	skos:altLabel	"IPCT"
REACT:R-XTR-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Xenopus tropicalis)
RHEA:23106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate => D-arabinose 5-phosphate
RHEA:36523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
REACT:R-DRE-5626220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 binds the mother centriole (Danio rerio)
RHEA:64427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-leucyl-L-proline(out) <=> H(+)(in) + L-leucyl-L-proline(in)
REACT:R-SSC-909738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 bind the common beta chain (Sus scrofa)
REACT:R-HSA-5692779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S182 MAPKAPK5 phosphorylates FOXO1 (Homo sapiens)
REACT:R-SSC-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Sus scrofa)
REACT:R-SPO-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Schizosaccharomyces pombe)
REACT:R-MMU-174963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1 acetylation (Mus musculus)
RHEA:45886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA
REACT:R-BTA-8953398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIR oxygenates quercetin (Bos taurus)
REACT:R-GGA-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Gallus gallus)
REACT:R-SSC-166038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-bound CD14 binds LPS (Sus scrofa)
RHEA:44303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA
RHEA:25571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-ribosylnicotinate <=> ADP + H(+) + nicotinate beta-D-ribonucleotide
EC:3.2.1.83	skos:prefLabel	"kappa-carrageenase"
EC:3.2.1.83	skos:altLabel	"kappa-carrageenan 4-beta-D-glycanohydrolase"
EC:3.2.1.83	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kappa-carrageenase"
RHEA:44080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + undecanoate = AMP + diphosphate + undecanoyl-CoA
REACT:R-BTA-8853252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2:C3d,C3dg,iC3b binds CD19:CD81 (Bos taurus)
GO:0102335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase"
GO:0102335	skos:prefLabel	"N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase"
GO:0102335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP
GO:0102335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity
REACT:R-MMU-5138459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A:FZD4 is endocytosed (Mus musculus)
REACT:R-SSC-8939323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 binds BCL10 and Ubiquitin:E2 (Sus scrofa)
REACT:R-GGA-5687090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6 phosphorylates NCOA3 (Gallus gallus)
EC:4.1.2.5	skos:altLabel	"L-threonine acetaldehyde-lyase"
EC:4.1.2.5	skos:prefLabel	"L-threonine aldolase"
EC:4.1.2.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-threonine aldolase"
GO:0052640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity
GO:0052640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity
GO:0052640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity
GO:0052640	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	salicylic acid glucosyltransferase activity
GO:0052640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylate + UDP-alpha-D-glucose = H(+) + salicylate 2-O-beta-D-glucoside + UDP
GO:0052640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:SA glucosyltransferase (glucoside-forming) activity
GO:0052640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylic acid glucosyltransferase (glucoside-forming) activity
REACT:R-RNO-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Rattus norvegicus)
RHEA:55276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA
RHEA:40131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+)
GO:0031830	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 5A serotonin receptor ligand
GO:0031830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 5A receptor binding
GO:0031830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 5A serotonin receptor binding
REACT:R-XTR-9020255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Xenopus tropicalis)
RHEA:25825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermine => H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine
RHEA:63546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinetensin-(1-8) + L-leucine => H2O + kinetensin
REACT:R-DRE-8952625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Danio rerio)
REACT:R-BTA-202331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to SLP-76 (Bos taurus)
REACT:R-GGA-190326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 (Gallus gallus)
REACT:R-BTA-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Bos taurus)
REACT:R-XTR-110221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by SMUG1 glycosylase (Xenopus tropicalis)
RHEA:35537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2 => cyclo(L-phenylalanyl-L-leucyl) + O2
REACT:R-SSC-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Sus scrofa)
RHEA:50871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate
REACT:R-DDI-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Dictyostelium discoideum)
REACT:R-GGA-9011984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A is recruited to MYC and BCL2 genes (Gallus gallus)
RHEA:30877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-2-oxohexanoate + D-glutamate => 2-oxoglutarate + D-lysine
RHEA:50816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADPH = 5alpha-androstan-3,17-dione + NADP(+)
REACT:R-HSA-352191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A8-mediated uptake of neutral amino acids (Homo sapiens)
REACT:R-BTA-111238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR2  homodimer (Bos taurus)
REACT:R-RNO-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Rattus norvegicus)
REACT:R-CEL-904830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:62799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + 2 rubrofusarin B <=> aurasperone A + 2 H2O + NADP(+)
REACT:R-XTR-4085992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DAXX with SUMO1 (Xenopus tropicalis)
REACT:R-CFA-76466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4A11 12-hydroxylates DDCX (Canis familiaris)
REACT:R-SSC-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Sus scrofa)
RHEA:58755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)
REACT:R-SSC-139920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tBID to mitochondria (Sus scrofa)
REACT:R-CFA-417908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY1 binds ADP (Canis familiaris)
GO:0046905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate = 15-cis-phytoene + diphosphate
GO:0046905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene synthase activity
GO:0046905	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phytoene synthase activity
REACT:R-HSA-9038052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GREB1 binds ESR1:ESTG and co-activators (Homo sapiens)
REACT:R-DRE-5610723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind SUFU (Danio rerio)
GO:0033764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
RHEA:12185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH
REACT:R-GGA-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Gallus gallus)
REACT:R-SSC-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Sus scrofa)
REACT:R-XTR-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Xenopus tropicalis)
REACT:R-RNO-5654426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
REACT:R-SSC-8849857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates CELA2 (Sus scrofa)
RHEA:55844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP
REACT:R-XTR-9026967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 inhibitors binds VKORC1 dimer (Xenopus tropicalis)
REACT:R-HSA-4754176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR3-histone H3 (Homo sapiens)
REACT:R-CFA-400092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Canis familiaris)
REACT:R-DRE-71010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUT isomerises L-MM-CoA to SUCC-CoA (Danio rerio)
RHEA:56448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
RHEA:55135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanine + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate
RHEA:31070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-2-oxohexanoate <=> Delta(1)-piperideine-2-carboxylate + H2O
RHEA:34933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + hydrogenselenide + NADP(+) => glutathioselenol + NADPH
RHEA:52739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate <=> (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)
REACT:R-MMU-1433395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of sSCF (Mus musculus)
REACT:R-XTR-381487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP1 binds IGF forming IGF:IGFBP1 (Xenopus tropicalis)
RHEA:45858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA
RHEA:23453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + ATP => ADP + dAMP + H(+)
REACT:R-DRE-8851908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 (Danio rerio)
REACT:R-HSA-480515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FGF2 (Homo sapiens)
RHEA:62731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide D + FADH2
REACT:R-BTA-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Bos taurus)
RHEA:59478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol => 2 AH2 + 2 ATP + benzoate + L-phenylalanine
RHEA:60295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine
REACT:R-DRE-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Danio rerio)
RHEA:67864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-2530453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vitronectin (VTN) binds to C5b:C6:C7 (Canis familiaris)
REACT:R-HSA-2426471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Homo sapiens)
REACT:R-SCE-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Saccharomyces cerevisiae)
REACT:R-DDI-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Dictyostelium discoideum)
REACT:R-CEL-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Caenorhabditis elegans)
REACT:R-CFA-8852200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of LCK by PTPN22 (Canis familiaris)
REACT:R-HSA-9618582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds MYC gene:E2F1 (Homo sapiens)
REACT:R-GGA-1973968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 4A and 103 bind CCR2 (Gallus gallus)
REACT:R-BTA-173481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Bos taurus)
RHEA:26124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + L-proline = (S)-1-pyrroline-5-carboxylate + FADH2
RHEA:41132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-decanoyl-sn-glycero-3-phosphocholine + H2O => 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-DME-209183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Scaffolding protein CKA binds BSK and phosphorylated HEP kinases (Drosophila melanogaster)
REACT:R-SSC-8939706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) polyubiquitinates RUNX2 (Sus scrofa)
RHEA:64727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate
RHEA:33225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADH + propanoyl-CoA => 2-oxobutanoate + CoA + NAD(+)
REACT:R-DDI-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Dictyostelium discoideum)
REACT:R-DDI-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Dictyostelium discoideum)
RHEA:23575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisovalerophenone
RHEA:50362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl cyanide + H2O2 => (R)-mandelonitrile + O2
REACT:R-HSA-216045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I binds integrin alpha11beta1 (Homo sapiens)
RHEA:56133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA => a thymidine dimer in DNA
GO:0102443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
RHEA:27646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine
REACT:R-HSA-8984964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12A gene transcription and translation (Homo sapiens)
RHEA:18410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH
REACT:R-BTA-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Bos taurus)
REACT:R-CFA-109380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Canis familiaris)
RHEA:51032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloroindole-3-pyruvate imine dimer = dichlorochromopyrrolate + H(+) + NH4(+)
RHEA:65932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase"
RHEA:65932	skos:prefLabel	"2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase"
RHEA:65932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine = 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Canis familiaris)
REACT:R-PFA-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Plasmodium falciparum)
RHEA:54338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline
REACT:R-BTA-8982645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRKs bind ADRB2:Catecholamine (Bos taurus)
REACT:R-CEL-5359451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from SAM to NAM to form MNA (Caenorhabditis elegans)
REACT:R-DRE-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Danio rerio)
RHEA:24600	skos:prefLabel	"sulfite oxidase"
RHEA:24600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfite oxidase"
RHEA:24600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + sulfite = H2O2 + sulfate
RHEA:11653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
RHEA:62830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
RHEA:59819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + a sterol <=> a sterol ester + CoA
RHEA:12383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2,4-diaminobutanoate + pyruvate <=> L-alanine + L-aspartate 4-semialdehyde
REACT:R-HSA-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Homo sapiens)
RHEA:65751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dodecyl sulfate + O2 <=> CO2 + dodecanal + H(+) + succinate + sulfate
RHEA:55850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA
REACT:R-XTR-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Xenopus tropicalis)
RHEA:41434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-3-methyl-L-tyrosine + H2O => 3-methyl-L-tyrosine + H2O2
RHEA:35231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin(in) = rifampicin(out)
REACT:R-GGA-9632906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ recruits RAS in response to estrogen stimulation (Gallus gallus)
REACT:R-HSA-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Homo sapiens)
REACT:R-BTA-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Bos taurus)
REACT:R-HSA-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Homo sapiens)
REACT:R-HSA-450133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)
REACT:R-CFA-5686335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF2RA:CSF2RB binds SFTPs (Canis familiaris)
REACT:R-HSA-9038658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHD gene produces PALM-C-Rhesus D protein (Homo sapiens)
RHEA:42851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyltetracenomycin C + dTDP-beta-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)
RHEA:21464	skos:prefLabel	"thiocyanate hydrolase"
RHEA:21464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiocyanate hydrolase"
RHEA:21464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + thiocyanate = carbonyl sulfide + NH4(+)
RHEA:32156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine => adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine
REACT:R-DME-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Drosophila melanogaster)
RHEA:16873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase [NAD(P)H-oxidizing]"
RHEA:16873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)
RHEA:16873	skos:altLabel	"folate/FAD-dependent tRNA T54 methyltransferase"
RHEA:16873	skos:altLabel	"folate-dependent ribothymidyl synthase"
RHEA:16873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)
RHEA:16873	skos:prefLabel	"methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase [NAD(P)H-oxidizing]"
RHEA:31059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + imidazole-4-acetaldehyde + NAD(+) = 2 H(+) + imidazole-4-acetate + NADH
REACT:R-HSA-374664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of Ezrin (Homo sapiens)
REACT:R-XTR-9661419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds extracellular heme (Xenopus tropicalis)
REACT:R-HSA-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)
REACT:R-PFA-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Plasmodium falciparum)
REACT:R-DRE-8853793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET complexes bind GRB2 (Danio rerio)
RHEA:21969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate => 3-dehydroquinate + phosphate
RHEA:56158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine
REACT:R-RNO-8950269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Rattus norvegicus)
RHEA:28502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + S-(hydroxymethyl)mycothiol = H(+) + NADH + S-formylmycothiol
RHEA:28502	skos:altLabel	"NAD/factor-dependent formaldehyde dehydrogenase"
RHEA:28502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-(hydroxymethyl)mycothiol dehydrogenase"
RHEA:28502	skos:altLabel	"mycothiol-dependent formaldehyde dehydrogenase"
RHEA:28502	skos:prefLabel	"S-(hydroxymethyl)mycothiol dehydrogenase"
REACT:R-DDI-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Dictyostelium discoideum)
RHEA:35992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:45379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine
REACT:R-HSA-4085347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO1 (Homo sapiens)
GO:0016155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N10-formyltetrahydrofolate dehydrogenase activity
GO:0016155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyl-H4folate dehydrogenase activity
GO:0016155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyltetrahydrofolate:NADP+ oxidoreductase activity
GO:0016155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyltetrahydrofolate dehydrogenase activity
GO:0016155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyl tetrahydrofolate:NADP oxidoreductase activity
GO:0016155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyl-H2PtGlu:NADP oxidoreductase activity
GO:0016155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyltetrahydrofolate dehydrogenase activity
REACT:R-GGA-8853793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET complexes bind GRB2 (Gallus gallus)
REACT:R-GGA-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Gallus gallus)
REACT:R-HSA-8942099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)
RHEA:32250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH
REACT:R-HSA-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Homo sapiens)
RHEA:50039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine
REACT:R-DRE-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Danio rerio)
RHEA:68399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a percarboxylic acid + H2O <=> a carboxylate + H(+) + H2O2
RHEA:43525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine + NADP(+) => aminoacetone + CO2 + NADPH
GO:0030770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	demethylmacrocin methyltransferase activity
GO:0030770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity
GO:0030770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylmacrocin O-methyltransferase activity
REACT:R-CEL-2127257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Caenorhabditis elegans)
REACT:R-BTA-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Bos taurus)
REACT:R-HSA-6806405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates PMS2 expression (Homo sapiens)
RHEA:27736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O
RHEA:33151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoamide + acetyl-CoA = (R)-S(6)-acetyldihydrolipoamide + CoA
REACT:R-CFA-8941234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Canis familiaris)
REACT:R-DME-2066299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 binds phosphorylated WWTR1 (TAZ) (Drosophila melanogaster)
RHEA:52144	skos:altLabel	"2-phosphinomethylmalic acid synthase"
RHEA:52144	skos:altLabel	"PMM synthase"
RHEA:52144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-phosphonomethylmalate synthase"
RHEA:52144	skos:prefLabel	"2-phosphonomethylmalate synthase"
RHEA:52144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphonopyruvate + acetyl-CoA + H2O = (R)-2-(phosphonomethyl)malate + CoA + H(+)
REACT:R-DRE-6811423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Danio rerio)
GO:0103104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylthiohexyldesulfoglucosinolate sulfotransferase activity
REACT:R-DME-8986083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates ROBO1 (Drosophila melanogaster)
RHEA:12235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) <=> [thioredoxin]-dithiol + glycine + H(+) + phosphate
REACT:R-CEL-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
REACT:R-CFA-205112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Canis familiaris)
REACT:R-SCE-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-CFA-5675470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC2/3 (cIAP1/2) is autoubiquitinated (Canis familiaris)
REACT:R-HSA-5358619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) (Homo sapiens)
REACT:R-CFA-5693584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Canis familiaris)
RHEA:69840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-211346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein (Homo sapiens)
REACT:R-RNO-176604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Rattus norvegicus)
REACT:R-XTR-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
EC:3.4.23.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pepsin B"
EC:3.4.23.2	skos:altLabel	"parapepsin I"
EC:3.4.23.2	skos:prefLabel	"pepsin B"
REACT:R-RNO-4341073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates PGR with SUMO1 (Rattus norvegicus)
REACT:R-XTR-445069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-EGFR trans-heterodimerization (Xenopus tropicalis)
RHEA:67599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptadecasphing-4-enine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine
REACT:R-RNO-6799179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Rattus norvegicus)
RHEA:22261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triacetate lactone => H(+) + triacetate
RHEA:44577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) => 2-all-trans-nonaprenylphenol + CO2
RHEA:14226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexanoate + NAD(+) => 6-oxohexanoate + H(+) + NADH
REACT:R-HSA-3209114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translation of p16INK4A mRNA is inhibited by miR-24 (Homo sapiens)
RHEA:14135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:11831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O <=> a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)
REACT:R-HSA-5634750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Homo sapiens)
REACT:R-CFA-2130731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of COPII vesicle (Canis familiaris)
REACT:R-MMU-188979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Mus musculus)
REACT:R-CEL-265645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Influx through Voltage-gated Calcium Channels (Caenorhabditis elegans)
RHEA:19802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + ATP + H(+) => 3'-dephospho-CoA + diphosphate
EC:1.1.1.232	skos:prefLabel	"15-hydroxyicosatetraenoate dehydrogenase"
EC:1.1.1.232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"15-hydroxyicosatetraenoate dehydrogenase"
REACT:R-HSA-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Homo sapiens)
REACT:R-CFA-5654622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
GO:0070089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride-activated potassium channel activity
REACT:R-XTR-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Xenopus tropicalis)
REACT:R-BTA-5689649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 (Bos taurus)
REACT:R-GGA-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Gallus gallus)
RHEA:18180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + NAD(+) <=> a (2E)-enoyl-CoA + H(+) + NADH
RHEA:37045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate => ATP + H2O + L-alanyl-L-glutamate(out)
REACT:R-MMU-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Mus musculus)
GO:0004174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ETF-ubiquinone oxidoreductase activity
GO:0004174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	electron transfer flavoprotein-ubiquinone oxidoreductase activity
GO:0004174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	electron-transferring-flavoprotein:ubiquinone oxidoreductase activity
GO:0004174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	electron-transferring-flavoprotein dehydrogenase activity
GO:0004174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	electron transfer flavoprotein dehydrogenase activity
GO:0004174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ETF:ubiquinone oxidoreductase activity
GO:0004174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ETF dehydrogenase activity
GO:0004174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	electron transfer flavoprotein reductase activity
GO:0004174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	electron transfer flavoprotein Q oxidoreductase activity
GO:0004174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ETF-QO activity
REACT:R-SSC-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Sus scrofa)
REACT:R-XTR-8944257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIV (Xenopus tropicalis)
REACT:R-BTA-1475026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)
REACT:R-SSC-193997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B1 oxidises 11DCORT (Sus scrofa)
REACT:R-DRE-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Danio rerio)
REACT:R-RNO-1974676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta defensin 103 activates TLR1:TLR2 (Rattus norvegicus)
RHEA:58238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => L-tyrosyl-[protein] + NAD(+)
RHEA:47707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + iso-precytochalasin + NADPH + O2 <=> cytochalasin Z16 + H2O + NADP(+)
RHEA:70708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-beta-D-quinovose => 6-sulfo-D-rhamnose
REACT:R-DME-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Drosophila melanogaster)
RHEA:41983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH
RHEA:22723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidyl-[protein] <=> ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]
REACT:R-HSA-216069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)
RHEA:55350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol => all-trans-retinol
RHEA:16906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine
REACT:R-CEL-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Caenorhabditis elegans)
REACT:R-SSC-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Sus scrofa)
REACT:R-BTA-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Bos taurus)
RHEA:60022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sesquisabinene A => (2E,6E)-farnesyl diphosphate
REACT:R-BTA-5607722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK phosphorylates IKKA dimer (Bos taurus)
REACT:R-BTA-110354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of OGG1 glycosylase by APEX1 at the AP site (Bos taurus)
REACT:R-MMU-202917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 1 (Mus musculus)
RHEA:55490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:42918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine
RHEA:71012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(in) + L-phenylalanine(out) => L-isoleucine(out) + L-phenylalanine(in)
REACT:R-HSA-1592316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP1 (Homo sapiens)
REACT:R-CFA-5624953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL13B binds INPP5E (Canis familiaris)
RHEA:43089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine => 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-9710101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP4, CASP5 cleave GSDMD (Bos taurus)
RHEA:60678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(-)-citronellal + H(+) + NADH => (S)-(-)-citronellol + NAD(+)
RHEA:30301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleobase within DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a methylated nucleobase within DNA + O2
REACT:R-DRE-8942607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Danio rerio)
REACT:R-SSC-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Sus scrofa)
GO:0047822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypotaurine dehydrogenase activity
REACT:R-SSC-166869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MEKK1 (Sus scrofa)
GO:0102243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + ATP = (2E)-geranyl phosphate + ADP + H(+)
GO:0102243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:geranylgeraniol phosphotransferase activity
RHEA:42852	skos:prefLabel	"2-methylbutanoate polyketide synthase"
RHEA:42852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methylbutanoate polyketide synthase"
RHEA:42852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-6785165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Mus musculus)
RHEA:64310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + L-alanine => 3-aminobutanoate + pyruvate
RHEA:15816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1H-imidazole + acetyl-CoA <=> CoA + N-acetylimidazole
REACT:R-HSA-5683325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol (Homo sapiens)
GO:0031853	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nociceptin receptor ligand
GO:0031853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nociceptin receptor binding
REACT:R-BTA-77283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Bos taurus)
RHEA:37463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-BTA-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Bos taurus)
REACT:R-XTR-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Xenopus tropicalis)
REACT:R-SSC-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)
RHEA:39080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydodecanedioyl-CoA + NAD(+) => 3-oxododecanedioyl-CoA + H(+) + NADH
GO:0102117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A9 carboxyl methyltransferase activity
RHEA:17866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydropteridine + NADP(+) => 6,7-dihydropteridine + H(+) + NADPH
RHEA:62858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
RHEA:37015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:66712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate
REACT:R-GGA-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Gallus gallus)
REACT:R-CFA-2090037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(6) (Canis familiaris)
GO:0004901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte macrophage colony stimulating factor receptor activity
GO:0004901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF-2 receptor activity
GO:0004901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF receptor activity
GO:0004901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMC-SF receptor activity
GO:0004901	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CSF2R
GO:0004901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte macrophage colony-stimulating factor receptor activity
REACT:R-MMU-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Mus musculus)
REACT:R-DDI-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
RHEA:47796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aralkylamine dehydrogenase (azurin)"
RHEA:47796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]
RHEA:47796	skos:altLabel	"arylamine dehydrogenase"
RHEA:47796	skos:altLabel	"aromatic amine dehydrogenase"
RHEA:47796	skos:prefLabel	"aralkylamine dehydrogenase (azurin)"
RHEA:12961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate
RHEA:12961	skos:prefLabel	"butyrate--acetoacetate CoA-transferase"
RHEA:12961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"butyrate--acetoacetate CoA-transferase"
REACT:R-RNO-9714959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to TNF(1-233) trimer (Rattus norvegicus)
GO:0030229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL receptor
GO:0030229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-low-density lipoprotein particle receptor activity
GO:0030229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-low-density lipoprotein receptor activity
GO:0030229	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	apolipoprotein E receptor activity
RHEA:60141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetradecanoyl-CoA + CO2 + CoA
REACT:R-GGA-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Gallus gallus)
REACT:R-RNO-8851954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GAB1 recruits PI3K to MET (Rattus norvegicus)
REACT:R-HSA-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Homo sapiens)
REACT:R-CFA-2130641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TGN-lysosome vesicle to lysosome (Canis familiaris)
RHEA:43061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => beta-D-glucose 1-phosphate + glycerol
RHEA:65623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinga-(4E,8E)-dienine <=> CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine
REACT:R-HSA-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Homo sapiens)
RHEA:48200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA = reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA
REACT:R-DME-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Drosophila melanogaster)
REACT:R-RNO-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Rattus norvegicus)
REACT:R-GGA-173705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b binds C6 (Gallus gallus)
RHEA:12540	skos:prefLabel	"alanine--tRNA ligase"
RHEA:12540	skos:altLabel	"alanyl-tRNA synthetase"
RHEA:12540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alanine--tRNA ligase"
RHEA:12540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)
RHEA:12540	skos:altLabel	"alanine translase"
RHEA:53180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose = D-erythrulose
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexosaminidase A
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-acetylaminodeoxyhexosidase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-N-acetylhexosaminidase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-acetylhexosaminidinase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-N-acetyl-D-hexosaminidase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-beta-hexosaminidase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hexosaminidase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-N-acetylhexosaminidase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-beta-D-hexosaminidase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylhexosaminidase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-beta-glucosaminidase activity
GO:0004563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-hexosaminidase activity
REACT:R-RNO-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Rattus norvegicus)
REACT:R-RNO-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Rattus norvegicus)
REACT:R-DME-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Drosophila melanogaster)
RHEA:57296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+)
RHEA:12855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dhurrin + H(+) + UDP => (S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose
EC:1.3.1.117	skos:prefLabel	"hydroxycinnamoyl-CoA reductase"
EC:1.3.1.117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxycinnamoyl-CoA reductase"
EC:1.3.1.117	skos:altLabel	"hydroxycinnamoyl-CoA double bond reductase"
REACT:R-DRE-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Danio rerio)
REACT:R-HSA-211190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of DFF45 (117) (Homo sapiens)
REACT:R-XTR-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Xenopus tropicalis)
REACT:R-CFA-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)
RHEA:45421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-SCE-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Saccharomyces cerevisiae)
RHEA:11929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylamine + NH4(+) => H(+) + H2O + hydrazine
REACT:R-DME-947531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Drosophila melanogaster)
RHEA:53934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase]
GO:0090422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine pyrophosphate transmembrane transporter activity
GO:0090422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine diphosphate transporter activity
GO:0090422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thiamine pyrophosphate transporter activity
GO:0090422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Homo sapiens)
REACT:R-CFA-77321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Canis familiaris)
REACT:R-SSC-5624956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds INPP5E (Sus scrofa)
REACT:R-HSA-5654692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-DME-1296035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Drosophila melanogaster)
REACT:R-SSC-420592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectin-like (Necl) proteins (Sus scrofa)
RHEA:35232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin(in) => rifampicin(out)
REACT:R-HSA-9708104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE5A dimer binds PDE5A inhibitors (Homo sapiens)
REACT:R-HSA-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Homo sapiens)
GO:0050620	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity
GO:0050620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin:ferredoxin oxidoreductase activity
REACT:R-HSA-9749971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Homo sapiens)
REACT:R-RNO-446372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  PARVA with TESK1 (Rattus norvegicus)
RHEA:35700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-versiconol + NADP(+) => (2S-3S)-versiconal hemiacetal + H(+) + NADPH
RHEA:52678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine => [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O
REACT:R-DRE-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Danio rerio)
REACT:R-DDI-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Dictyostelium discoideum)
REACT:R-GGA-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Gallus gallus)
REACT:R-HSA-168859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) (Homo sapiens)
RHEA:62846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose
REACT:R-HSA-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Homo sapiens)
REACT:R-SSC-419981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Sus scrofa)
REACT:R-HSA-437118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI stimulates PI3K beta, gamma (Homo sapiens)
REACT:R-PFA-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)
REACT:R-BTA-190413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2c (Bos taurus)
REACT:R-HSA-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)
RHEA:33812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine => 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O
REACT:R-CEL-2485148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Caenorhabditis elegans)
REACT:R-HSA-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Homo sapiens)
REACT:R-RNO-1297333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Acrosin Heavy and Light Chain (Rattus norvegicus)
GO:0015531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate:hydrogen symporter activity
GO:0015531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + H(+)(in) = citrate(out) + H(+)(out)
GO:0015531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate:proton symporter activity
REACT:R-CFA-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Canis familiaris)
RHEA:30788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine
RHEA:21878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-usnate + 2 H(+) + NADH => (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+)
REACT:R-HSA-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Homo sapiens)
REACT:R-HSA-3769394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CBY1 (Homo sapiens)
REACT:R-DME-5263616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeO2H is reduced to MeSeOH by TXNRD1 (Drosophila melanogaster)
RHEA:45814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain (2E)-enoyl-CoA + H2O => a very-long-chain (3R)-3-hydroxyacyl-CoA
RHEA:32389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocarvone + H(+) + NADH => dihydrocarveol + NAD(+)
REACT:R-HSA-2395801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LAT by p-SYK (Homo sapiens)
REACT:R-MMU-5684052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates MDC1 (Mus musculus)
GO:0034536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-8-methylchromene-2-carboxylate isomerase activity
RHEA:43698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate
REACT:R-RNO-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-CFA-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Canis familiaris)
RHEA:11224	skos:altLabel	"D-alanyl-D-alanine synthetase"
RHEA:11224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-alanine--D-alanine ligase"
RHEA:11224	skos:altLabel	"D-Ala-D-Ala synthetase"
RHEA:11224	skos:altLabel	"alanylalanine synthetase"
RHEA:11224	skos:altLabel	"alanine:alanine ligase (ADP-forming)"
RHEA:11224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate
RHEA:11224	skos:prefLabel	"D-alanine--D-alanine ligase"
RHEA:11224	skos:altLabel	"D-alanylalanine synthetase"
RHEA:10287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine <=> (3R)-beta-leucine
REACT:R-CFA-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Canis familiaris)
RHEA:42068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH = clavulanate + NADP(+)
REACT:R-DRE-9757706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Danio rerio)
RHEA:62194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase] => O2 + peregrinol + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-5218812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates PAK2 (Bos taurus)
REACT:R-RNO-6794346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind NLGNs (Rattus norvegicus)
REACT:R-DRE-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Danio rerio)
REACT:R-HSA-168934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS interacts with RIPK1 and FADD (Homo sapiens)
REACT:R-CFA-9611751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1,2-agonists bind ADRB1,2 (Canis familiaris)
REACT:R-GGA-193668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR and RHOA-GDI interact (Gallus gallus)
GO:1990050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidic acid transfer activity
GO:1990050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidic acid carrier activity
GO:1990050	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidic acid transporter activity
GO:1990050	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane phosphatidic acid transfer activity
GO:1990050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intermembrane PA transfer activity
RHEA:63860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate
REACT:R-DRE-6798317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Danio rerio)
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	platelet-activating factor-synthesizing enzyme activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysopaf:acetyl CoA acetyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	platelet-activating factor acylhydrolase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lyso-platelet activating factor:acetyl-CoA acetyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-2-lysolecithin acetyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:lyso-PAF acetyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	blood platelet-activating factor acetyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkylglycerophosphocholine O-acetyltransferase activity
GO:0047192	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lyso-GPC:acetyl CoA acetyltransferase activity
REACT:R-DME-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Drosophila melanogaster)
REACT:R-HSA-9620813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
RHEA:34683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O = alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)
RHEA:34683	skos:prefLabel	"alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase"
RHEA:34683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase"
REACT:R-DRE-8952039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Danio rerio)
REACT:R-DRE-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Danio rerio)
REACT:R-RNO-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Rattus norvegicus)
RHEA:42496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate = 10-deacetyl-2-debenzoylbaccatin III
RHEA:69973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:23732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate
RHEA:23732	skos:prefLabel	"diphosphomevalonate decarboxylase"
RHEA:23732	skos:altLabel	"mevalonate pyrophosphate decarboxylase"
RHEA:23732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diphosphomevalonate decarboxylase"
RHEA:23732	skos:altLabel	"mevalonate diphosphate decarboxylase"
REACT:R-MMU-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Mus musculus)
REACT:R-CFA-9677929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB inhibitors bind MAOB:FAD (Canis familiaris)
RHEA:37121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe) => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine
REACT:R-BTA-5226964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKH transports PPi from cytosol to extracellular region (Bos taurus)
REACT:R-MMU-110231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by MBD4 glycosylase (Mus musculus)
REACT:R-BTA-163099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alignment Of The RNA Template On The Telomeric Chromosome End (Bos taurus)
RHEA:72194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:18945	skos:prefLabel	"procollagen-proline 4-dioxygenase"
RHEA:18945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]
RHEA:18945	skos:altLabel	"proline hydroxylase"
RHEA:18945	skos:altLabel	"procollagen-proline dioxygenase"
RHEA:18945	skos:altLabel	"prolyl 4-hydroxylase"
RHEA:18945	skos:altLabel	"proline,2-oxoglutarate 4-dioxygenase"
RHEA:18945	skos:altLabel	"prolyl hydroxylase"
RHEA:18945	skos:altLabel	"protocollagen hydroxylase"
RHEA:18945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"procollagen-proline 4-dioxygenase"
RHEA:18945	skos:altLabel	"procollagen-proline,2-oxoglutarate-4-dioxygenase"
RHEA:11115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isochorismate <=> (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate
REACT:R-BTA-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)
RHEA:17233	skos:prefLabel	"L-fucose isomerase"
RHEA:17233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-fucose isomerase"
RHEA:17233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fucose = L-fuculose
REACT:R-SSC-9634834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACHEIs bind ACHE (Sus scrofa)
REACT:R-HSA-9005561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308 (Homo sapiens)
REACT:R-GGA-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Gallus gallus)
RHEA:11507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-demethylsterigmatocystin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sterigmatocystin
RHEA:36640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine => 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine
RHEA:25288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
GO:0008852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Escherichia coli exonuclease I
GO:0008852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exonuclease I activity
GO:0008852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exodeoxyribonuclease I activity
GO:0008852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E. coli exonuclease I
GO:0008852	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	E. coli exonuclease I activity
REACT:R-HSA-6811472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)
RHEA:40694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol <=> 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:10895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate + NAD(+) <=> (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH
REACT:R-HSA-9689680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNG inhibitors (Homo sapiens)
REACT:R-CFA-8871370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Canis familiaris)
GO:0106328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
RHEA:64371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2
REACT:R-HSA-170824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Homo sapiens)
REACT:R-XTR-2064421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds ZO-2 (TJP2) (Xenopus tropicalis)
GO:0050697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1,2-trichloroethene reductive dehalogenase activity
GO:0050697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1,2-trichloroethylene reductive dehalogenase activity
GO:0050697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCE-reductive dehalogenase activity
RHEA:52109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
RHEA:22849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyoctanedioyl-CoA + NAD(+) => 3-oxooctanedioyl-CoA + H(+) + NADH
EC:3.4.19.1	skos:altLabel	"acylamino-acid-releasing enzyme"
EC:3.4.19.1	skos:altLabel	"N-acylpeptide hydrolase"
EC:3.4.19.1	skos:prefLabel	"acylaminoacyl-peptidase"
EC:3.4.19.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acylaminoacyl-peptidase"
REACT:R-MMU-9761344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 binds IKBKG within IKK complex (Mus musculus)
REACT:R-MMU-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)
REACT:R-CFA-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Canis familiaris)
RHEA:39539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)
REACT:R-SSC-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Sus scrofa)
REACT:R-GGA-421201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate (Gallus gallus)
REACT:R-BTA-8875374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds LRIG1 (Bos taurus)
REACT:R-CFA-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Canis familiaris)
RHEA:51076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate = 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SCE-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Saccharomyces cerevisiae)
RHEA:14529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + phosphate
RHEA:14529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP ribose phosphorylase"
RHEA:14529	skos:prefLabel	"ADP ribose phosphorylase"
RHEA:14529	skos:altLabel	"ADP-ribose phosphorylase"
RHEA:14529	skos:altLabel	"ribose-5-phosphate adenylyltransferase"
RHEA:33936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide
REACT:R-BTA-1474213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP1,8,9,13 (Bos taurus)
REACT:R-HSA-913451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3RB is phosphorylated on Ser-585 (Homo sapiens)
REACT:R-BTA-209055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)
REACT:R-DRE-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Danio rerio)
RHEA:70668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]
REACT:R-RNO-9668831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CST complex formation (Rattus norvegicus)
RHEA:49283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 + phenol <=> catechol + FAD + H(+) + H2O
REACT:R-BTA-5675206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEA15 binds MAPK monomers and dimers (Bos taurus)
RHEA:10882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + D-ribose + H(+) => 7-methylxanthosine + H2O
GO:0004948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitonin receptor activity
RHEA:19683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + biotinyl-CoA + diphosphate => ATP + biotin + CoA
REACT:R-HSA-211962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F11 16-hydroxylates 3OH-PALM (Homo sapiens)
REACT:R-XTR-9714361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC activates endoplasmic reticulum effectors (Xenopus tropicalis)
REACT:R-BTA-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Bos taurus)
REACT:R-DME-9618378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 binds the Nup107-Nup160 complex (Drosophila melanogaster)
REACT:R-CFA-9034053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Canis familiaris)
REACT:R-XTR-373730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin and NrCAM heterodimerization (Xenopus tropicalis)
RHEA:51354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-serine => H2O + N-(9Z-octadecenoyl)-L-serine
REACT:R-RNO-1630304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Rattus norvegicus)
REACT:R-HSA-2220816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 binds CNTN1 (Homo sapiens)
REACT:R-DME-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Drosophila melanogaster)
RHEA:20135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-pyruvate + NADH => 3-(indol-3-yl)lactate + NAD(+)
GO:0106138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec61 translocon complex binding
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-N-acetyl-beta-1,4-galactosyltransferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GalT activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thyroid glycoprotein beta-galactosyltransferase
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-glycoprotein galactosyltransferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoprotein 4-beta-galactosyltransferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-N-acetyl-beta-(1,4)-galactosyltransferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoprotein beta-galactosyltransferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose-glycoprotein galactosyltransferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thyroid galactosyltransferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoprotein 4-beta-galactosyl-transferase activity
GO:0003831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose--glycoprotein galactosyltransferase activity
REACT:R-CFA-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Canis familiaris)
REACT:R-DME-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Drosophila melanogaster)
RHEA:16528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-galactonate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)
RHEA:52994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine
REACT:R-RNO-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)
REACT:R-HSA-9703430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 fusions:GRB2 bind SOS1 (Homo sapiens)
REACT:R-CFA-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Canis familiaris)
REACT:R-RNO-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Rattus norvegicus)
REACT:R-SSC-9706328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS2 (Sus scrofa)
RHEA:14546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nicotinamide => NH4(+) + nicotinate
RHEA:43307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer <=> 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SSC-5687094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 phosphorylate MAPKAPK5 (Sus scrofa)
RHEA:22685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 => (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O
REACT:R-MMU-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Mus musculus)
REACT:R-CFA-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Canis familiaris)
REACT:R-BTA-174444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C-strand Okazaki fragments (Bos taurus)
REACT:R-SSC-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Sus scrofa)
RHEA:28656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione S,S-dioxide + H2O => glutathione + H(+) + sulfite
RHEA:53562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-1606789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses DS (Bos taurus)
RHEA:17622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + citramalate => (3S)-citramalyl-CoA + acetate
REACT:R-DME-110506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated DTOR phosphorylates DS6K (Drosophila melanogaster)
RHEA:59592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-arginine = ADP + beta-alanyl-L-arginine + H(+) + phosphate
RHEA:41301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + sphing-4-enine => H2O + N-(9Z-octadecenoyl)-sphing-4-enine
REACT:R-CFA-2730884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of NTAL by p-SYK/Lyn (Canis familiaris)
REACT:R-HSA-9694792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)
REACT:R-HSA-391151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47:SKAP2 binds FYB (Homo sapiens)
RHEA:64470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+)
REACT:R-CEL-6801762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A oligomerize to form a pore complex (Caenorhabditis elegans)
RHEA:39438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)
REACT:R-GGA-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Gallus gallus)
REACT:R-GGA-8987070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Gallus gallus)
REACT:R-SPO-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Schizosaccharomyces pombe)
REACT:R-XTR-388832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds CD28 (Xenopus tropicalis)
GO:0047986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity
GO:0047986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen-sulphide S-acetyltransferase activity
GO:0047986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen-sulfide S-acetyltransferase activity
GO:0047986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen-sulfide acetyltransferase activity
RHEA:45986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2
RHEA:68306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein]
REACT:R-HSA-9623168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter (Homo sapiens)
REACT:R-MMU-1855176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Mus musculus)
REACT:R-HSA-8961840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the CCNE1 gene promoter (Homo sapiens)
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosinetetraphosphatase (symmetrical) activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine tetraphosphate phosphodiesterase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dinucleosidetetraphosphatase (symmetrical) activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dinucleosidetetraphosphate (symmetrical)
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine tetraphosphate hydrolase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Ap4A hydrolase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Ap(4)A hydrolase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	symmetrical diadenosine tetraphosphate hydrolase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5',5'''-P1,P4-tetraphosphatase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bis(5'-adenosyl) tetraphosphatase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine polyphosphate hydrolase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity
GO:0008803	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	diadenosine tetraphosphatase (symmetrical)
REACT:R-HSA-264689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Homo sapiens)
RHEA:25170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxohexanoate + H(+) => 6-hydroxyhexan-6-olide
RHEA:26080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanesulfonate + NADH + O2 <=> formaldehyde + H2O + NAD(+) + sulfite
REACT:R-GGA-5654714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
REACT:R-BTA-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Bos taurus)
REACT:R-HSA-8854462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds VLDL (Homo sapiens)
REACT:R-CFA-445797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)
RHEA:16893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridine N-methyltransferase"
RHEA:16893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridine + S-adenosyl-L-methionine = N-methylpyridinium + S-adenosyl-L-homocysteine
RHEA:16893	skos:prefLabel	"pyridine N-methyltransferase"
RHEA:53786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-muricholoyl-CoA + deoxycholate => beta-muricholate + deoxycholoyl-CoA
GO:0047812	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-amino acid acetyltransferase activity
GO:0047812	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:D-amino-acid N-acetyltransferase activity
GO:0047812	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-amino acid-alpha-N-acetyltransferase activity
GO:0047812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-amino-acid N-acetyltransferase activity
REACT:R-XTR-1614362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Xenopus tropicalis)
RHEA:19606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a chlorophyll + H2O => a chlorophyllide + H(+) + phytol
REACT:R-SSC-913451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3RB is phosphorylated on Ser-585 (Sus scrofa)
REACT:R-SSC-6795460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK1 phosphorylates MDM2 (Sus scrofa)
REACT:R-RNO-909724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IFNAR1 (Rattus norvegicus)
RHEA:39768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Homo sapiens)
REACT:R-HSA-5358512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near  insertion/deletion loop of 2 bases or more (Homo sapiens)
REACT:R-XTR-8942208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOXE3 isomerises 12R-HpETE to HXA3 (Xenopus tropicalis)
REACT:R-BTA-196372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Bos taurus)
RHEA:13451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + NADH => 2-hydroxyglutarate + NAD(+)
REACT:R-RNO-418850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 (Rattus norvegicus)
REACT:R-SSC-3928640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs phosphorylate MLC (Sus scrofa)
GO:0050213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta4-steroid 5alpha-reductase (progesterone)
GO:0050213	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid 5-alpha-reductase activity
GO:0050213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	progesterone 5-alpha-reductase activity
GO:0050213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	progesterone 5alpha-reductase activity
GO:0050213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity
GO:0050213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	progesterone 5a-reductase activity
REACT:R-BTA-9678935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Bos taurus)
REACT:R-DRE-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Danio rerio)
REACT:R-CEL-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Caenorhabditis elegans)
REACT:R-CFA-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Canis familiaris)
RHEA:52345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SCE-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Saccharomyces cerevisiae)
RHEA:32304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-homocitrate => (2R,3S)-homoisocitrate
REACT:R-SSC-8952903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRHL2 hydrolyses poly(ADP-ribose) (Sus scrofa)
RHEA:21980	skos:altLabel	"heparan sulfate N-sulfotransferase"
RHEA:21980	skos:altLabel	"N-HSST"
RHEA:21980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[heparan sulfate]-glucosamine N-sulfotransferase"
RHEA:21980	skos:altLabel	"heparin N-sulfotransferase"
RHEA:21980	skos:altLabel	"heparan sulfate N-deacetylase/N-sulfotransferase"
RHEA:21980	skos:altLabel	"3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase"
RHEA:21980	skos:altLabel	"heparan sulfate 2-N-sulfotransferase"
RHEA:21980	skos:prefLabel	"[heparan sulfate]-glucosamine N-sulfotransferase"
RHEA:21980	skos:altLabel	"heparitin sulfotransferase"
RHEA:21980	skos:altLabel	"glucosaminyl N-deacetylase/N-sulfotransferase"
RHEA:21980	skos:altLabel	"3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase"
RHEA:21980	skos:altLabel	"desulfoheparin sulfotransferase"
RHEA:21980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)
RHEA:21980	skos:altLabel	"3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase"
RHEA:21980	skos:altLabel	"heparan sulfate sulfotransferase"
RHEA:21980	skos:altLabel	"N-heparan sulfate sulfotransferase"
RHEA:21980	skos:altLabel	"PAPS:N-desulfoheparin sulfotransferase"
RHEA:21980	skos:altLabel	"PAPS:DSH sulfotransferase"
RHEA:21980	skos:altLabel	"N-desulfoheparin sulfotransferase"
REACT:R-RNO-192051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7A1 7-hydroxylates CHOL (Rattus norvegicus)
RHEA:66145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methoxytryptamine + acetyl-CoA => CoA + H(+) + melatonin
REACT:R-CEL-8944247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VI (Caenorhabditis elegans)
RHEA:18198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-cyclohexylformamide => cyclohexyl isocyanide + H2O
REACT:R-CEL-9733969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts dissociate from FABP6 (Caenorhabditis elegans)
REACT:R-BTA-83793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Bos taurus)
REACT:R-BTA-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Bos taurus)
REACT:R-CEL-432897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ILK interacts with beta-1 integrin (Caenorhabditis elegans)
RHEA:32480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 iodide + L-tyrosine + 2 NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH
REACT:R-RNO-6807118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)
REACT:R-PFA-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Plasmodium falciparum)
RHEA:32616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeraniol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH
RHEA:24755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite <=> 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-5635864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH ubiquitinates GLI1 (Canis familiaris)
REACT:R-CFA-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Canis familiaris)
REACT:R-BTA-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Bos taurus)
REACT:R-XTR-6797974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRTMs bind NRXNs (Xenopus tropicalis)
RHEA:32467	skos:altLabel	"sarcosine dimethylglycine N-methyltransferase"
RHEA:32467	skos:altLabel	"ApDMT"
RHEA:32467	skos:prefLabel	"sarcosine/dimethylglycine N-methyltransferase"
RHEA:32467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sarcosine/dimethylglycine N-methyltransferase"
RHEA:32467	skos:altLabel	"SDMT"
RHEA:32467	skos:altLabel	"sarcosine-dimethylglycine methyltransferase"
RHEA:32467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + sarcosine = glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-BTA-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Bos taurus)
GO:1905502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-coenzyme A binding
GO:1905502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA binding
RHEA:69961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:43097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-DME-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Drosophila melanogaster)
RHEA:20255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylmaleate + H2O => (2R,3S)-2,3-dimethylmalate
RHEA:56024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
GO:0042281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
GO:0042281	skos:prefLabel	"dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase"
GO:0042281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
GO:0042281	skos:altLabel	"Dol-P-Glc:Man9GlcNAc2-PP-Dol alpha-1->3-glucosyltransferase"
GO:0042281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity
GO:0042281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase"
REACT:R-PFA-5687123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S115 MAPKAPK5 translocates to the cytosol (Plasmodium falciparum)
RHEA:71753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + glutarate(out) => 2-oxoglutarate(out) + glutarate(in)
REACT:R-BTA-389424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The orphan QRFP receptor can bind neuropeptide QRFP (Bos taurus)
REACT:R-BTA-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Bos taurus)
REACT:R-CEL-159050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Caenorhabditis elegans)
RHEA:42236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:70333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetate + CoA + H(+) => 3-hydroxyphenylacetyl-CoA + H2O
RHEA:59180	skos:prefLabel	"pApA phosphodiesterase"
RHEA:59180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pApA phosphodiesterase"
RHEA:59180	skos:altLabel	"pApA hydrolase"
RHEA:59180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP + H(+)
REACT:R-BTA-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Bos taurus)
RHEA:19158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylonate => 2-dehydro-3-deoxy-D-arabinonate + H2O
REACT:R-SPO-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Schizosaccharomyces pombe)
REACT:R-SSC-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Sus scrofa)
RHEA:14447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O
RHEA:16346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate
REACT:R-DME-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Drosophila melanogaster)
REACT:R-SSC-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Sus scrofa)
REACT:R-MMU-77609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of APOBEC-1 to form editosome (Mus musculus)
RHEA:27389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-o-hydroxybenzylidenepyruvate hydratase-aldolase"
RHEA:27389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O = pyruvate + salicylaldehyde
RHEA:27389	skos:prefLabel	"trans-o-hydroxybenzylidenepyruvate hydratase-aldolase"
RHEA:27389	skos:altLabel	"2'-hydroxybenzalpyruvate aldolase"
REACT:R-DDI-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Dictyostelium discoideum)
REACT:R-CFA-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Canis familiaris)
REACT:R-SSC-9029667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DFF dissociates from importin-alpha:importin-beta (Sus scrofa)
REACT:R-XTR-5685985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Xenopus tropicalis)
GO:0008320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein transmembrane transporter activity
GO:0008320	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein channel activity
GO:0015049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methane hydroxylase activity
GO:0015049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)
GO:0015049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methane monooxygenase activity
RHEA:70558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-galactosamine
REACT:R-BTA-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Bos taurus)
REACT:R-XTR-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)
REACT:R-XTR-432909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Plectin with Integrin beta 4 (Xenopus tropicalis)
REACT:R-XTR-3364014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SET1 methyltransferase complex (Xenopus tropicalis)
GO:0102452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisdemethoxycurcumin synthase activity
REACT:R-GGA-8854628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLIP dimer ubiquitinates VLDLR on Lys-839 (Gallus gallus)
RHEA:55359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol <=> 13-cis-retinol
RHEA:63613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin + UDP-alpha-D-glucuronate => prunetin-5-O-beta-D-glucuronide + UDP
REACT:R-HSA-400256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRY:PER heterodimer binds the BMAL1:CLOCK/NPAS2 heterodimer (Homo sapiens)
REACT:R-GGA-1566962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by elastin-degrading extracellular proteinases (Gallus gallus)
REACT:R-CFA-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Canis familiaris)
REACT:R-BTA-382052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130Cas and C3G bind PDGFR bound Crk (Bos taurus)
REACT:R-MMU-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Mus musculus)
REACT:R-DRE-5610737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH bind and ubiquitnate GLI1 (Danio rerio)
RHEA:54125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine h dioxetanone => CO2 + excited coelenteramide h monoanion + H(+)
REACT:R-DME-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Drosophila melanogaster)
REACT:R-DME-9620515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2B,EP300 acetylate FOXO3 under oxidative stress (Drosophila melanogaster)
GO:0102754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide-b:phytyl-diphosphate phytyltransferase activity
REACT:R-XTR-1482543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Xenopus tropicalis)
REACT:R-HSA-2282889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ARSB does not hydrolyse C4S/C6S chains (Homo sapiens)
REACT:R-HSA-9610942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCMV Formation of Final Envelopment Complex (Homo sapiens)
RHEA:29510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-alpha-gurjunene + diphosphate
REACT:R-CEL-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Caenorhabditis elegans)
REACT:R-CFA-9029517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Canis familiaris)
REACT:R-DDI-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)
RHEA:66980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + H2O = 2-methylbutanoate + CoA + H(+)
REACT:R-XTR-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Xenopus tropicalis)
RHEA:38980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-SPO-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)
REACT:R-XTR-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Xenopus tropicalis)
RHEA:60211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 <=> 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate
RHEA:49786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + taurochenodeoxycholate => chenodeoxycholoyl-CoA + taurine
REACT:R-CFA-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Canis familiaris)
RHEA:58888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + AH2 + 2 O2 = 4-nitrobenzoate + A + 2 H2O
RHEA:58888	skos:prefLabel	"4-aminobenzoate N-oxygenase"
RHEA:58888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-aminobenzoate N-oxygenase"
REACT:R-DRE-69299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds geminin (Danio rerio)
REACT:R-RNO-8940561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP7 cleaves OPTC (Rattus norvegicus)
REACT:R-CFA-140870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Canis familiaris)
RHEA:57312	skos:prefLabel	"N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase"
RHEA:57312	skos:altLabel	"N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine deacylase"
RHEA:57312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase"
RHEA:57312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine = cytidine 5'-diphosphoramidate + H(+) + L-glutamate
REACT:R-RNO-1067667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R (Rattus norvegicus)
REACT:R-HSA-110237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUTYH mediated recognition and binding of an adenine opposite to an 8-oxoguanine (Homo sapiens)
REACT:R-HSA-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Homo sapiens)
REACT:R-DRE-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Danio rerio)
REACT:R-GGA-9021170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen stimulates dimerization of plasma membrane estrogen receptors (Gallus gallus)
RHEA:20288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate <=> alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine
REACT:R-HSA-202534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of NEMO by TRAF6 (Homo sapiens)
REACT:R-SSC-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Sus scrofa)
REACT:R-HSA-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Homo sapiens)
REACT:R-SSC-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Sus scrofa)
REACT:R-CFA-4084980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Canis familiaris)
GO:0034580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyloctanoyl-CoA dehydrogenase activity
REACT:R-CFA-74737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
REACT:R-CEL-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Caenorhabditis elegans)
REACT:R-DDI-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Dictyostelium discoideum)
REACT:R-DRE-6809015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Danio rerio)
REACT:R-GGA-5689861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of XPA and release of CAK  (Gallus gallus)
RHEA:59409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-aspartate => acetate + L-aspartate
RHEA:55795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-one + H(+) + NADH + O2 <=> 1-hydroxy-2-butanone + H2O + NAD(+)
GO:0018525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-CoA reductase activity
GO:0018525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity
GO:0018525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoyl-coA reductase (dehydroxylating) activity
RHEA:46039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + UTP <=> dCMP + H(+) + UDP
RHEA:58786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2
REACT:R-HSA-170072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Homo sapiens)
GO:0071889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 protein binding
RHEA:55425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] => (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(in) + L-methionine(out) => L-leucine(out) + L-methionine(in)
RHEA:63600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neocasomorphin = L-isoleucine + neocasomorphin-(1-5)
RHEA:18738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + hydrogenselenide => AMP + 2 H(+) + phosphate + selenophosphate
REACT:R-CFA-176517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to PREG (Canis familiaris)
REACT:R-DDI-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Dictyostelium discoideum)
REACT:R-DRE-432952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP180 interacts intracellularly with plectin and integrin beta4 (Danio rerio)
REACT:R-RNO-2176445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD2 (Rattus norvegicus)
REACT:R-CEL-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Caenorhabditis elegans)
REACT:R-DRE-2162019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to EXA4 by ALOX15 (Danio rerio)
GO:0033988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BA7 alpha dehydratase activity
GO:0033988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity
GO:0033988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity
GO:0033988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bile-acid 7alpha-dehydratase activity
GO:0030367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-17 receptor binding
GO:0030367	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-17
GO:0030367	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-17 receptor ligand
REACT:R-SSC-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Sus scrofa)
RHEA:31995	skos:prefLabel	"7-epi-sesquithujene synthase"
RHEA:31995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-epi-sesquithujene synthase"
RHEA:31995	skos:altLabel	"TPS4-B73"
RHEA:31995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = 7-epi-sesquithujene + diphosphate
REACT:R-HSA-398185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG binds plexin B1 (Homo sapiens)
REACT:R-BTA-4224014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by ADAM10, ADAM15 (Bos taurus)
REACT:R-BTA-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Bos taurus)
REACT:R-SSC-388831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CD28 (Sus scrofa)
RHEA:68573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine(in) => L-tyrosine(out)
RHEA:60918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine
RHEA:17185	skos:altLabel	"NADPH:guanosine-5'-phosphate oxidoreductase (deaminating)"
RHEA:17185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
RHEA:17185	skos:altLabel	"guanylate reductase"
RHEA:17185	skos:altLabel	"guanosine 5'-monophosphate oxidoreductase"
RHEA:17185	skos:altLabel	"guanosine 5'-monophosphate reductase"
RHEA:17185	skos:altLabel	"guanosine 5'-phosphate reductase"
RHEA:17185	skos:altLabel	"NADPH:GMP oxidoreductase (deaminating)"
RHEA:17185	skos:prefLabel	"GMP reductase"
RHEA:17185	skos:altLabel	"guanosine monophosphate reductase"
RHEA:17185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GMP reductase"
REACT:R-SPO-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Schizosaccharomyces pombe)
RHEA:23489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-benzoquinone + H(+) + NADPH => hydroquinone + NADP(+)
RHEA:43335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine
REACT:R-DME-193060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
RHEA:11771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate <=> 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate
REACT:R-DRE-211191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF with alpha:beta importin (Danio rerio)
RHEA:41023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA
REACT:R-GGA-8964317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Gallus gallus)
GO:0047704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bile-salt sulphotransferase activity
GO:0047704	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bile acid sulfotransferase I activity
GO:0047704	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycolithocholate sulfotransferase activity
GO:0047704	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity
GO:0047704	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity
GO:0047704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bile-salt sulfotransferase activity
GO:0047704	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	BAST I activity
GO:0047704	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity
RHEA:31364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) => 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)
RHEA:33886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-scyllo-inosamine + NAD(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH
REACT:R-RNO-3465448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)
REACT:R-SSC-2395320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 binds integrins (Sus scrofa)
REACT:R-SPO-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)
RHEA:63229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + spectinomycin => 9-O-adenylylspectinomycin + diphosphate
REACT:R-DRE-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Danio rerio)
REACT:R-BTA-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Bos taurus)
REACT:R-DRE-4084978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Danio rerio)
RHEA:29541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
GO:0140323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:anion antiporter activity
RHEA:37326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-methionine + H2O <=> glycine + L-methionine
REACT:R-CFA-936947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Canis familiaris)
REACT:R-HSA-9010541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISL1 binds the SLIT2 gene enhancer (Homo sapiens)
RHEA:72666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine
RHEA:27993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose + ATP <=> 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)
REACT:R-DME-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Drosophila melanogaster)
REACT:R-DME-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Drosophila melanogaster)
GO:0001882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside binding
GO:0004154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydropterin oxidase activity
GO:0047465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosmamine 6-phosphate 2-epimerase activity
GO:0047465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylmannosamine-6-phosphate 2-epimerase activity
GO:0047465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylglucosamine-6-phosphate 2-epimerase activity
GO:0047465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylmannosamine phosphate 2-epimerase activity
GO:0047465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylglucosamine phosphate 2-epimerase activity
GO:0047465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-D-glucosamine-6-phosphate 2-epimerase activity
GO:0047465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylglucosamine-6-phosphate 2-epimerase activity
RHEA:55516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-181450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Rattus norvegicus)
RHEA:47190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] => Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol
REACT:R-BTA-2160931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of tight junctions (Bos taurus)
REACT:R-XTR-5626228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The distal appendage proteins recruit TTBK2 (Xenopus tropicalis)
REACT:R-HSA-109514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Homo sapiens)
REACT:R-DRE-398193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC beta-mediated PIP2 hydrolysis (Danio rerio)
REACT:R-MMU-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Mus musculus)
GO:0051020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTPase binding
REACT:R-CEL-397891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:G12/13 (active) dissociate (Caenorhabditis elegans)
RHEA:41563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 <=> (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O
RHEA:52287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-RNO-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)
RHEA:57154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2
RHEA:30099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate
REACT:R-SSC-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Sus scrofa)
RHEA:50501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]
REACT:R-HSA-8948800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNKS and TNKS2 PARylate PTEN (Homo sapiens)
GO:0000149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAP receptor binding
GO:0000149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNARE binding
REACT:R-MMU-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Mus musculus)
REACT:R-MMU-8939335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 polyubiquinates BCL10 (Mus musculus)
REACT:R-RNO-8858346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMHR2 binds AMH (Rattus norvegicus)
RHEA:36584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-fucose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH
RHEA:38526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)
RHEA:69269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkenimidothioate => an alkenyl isothiocyanate + sulfate
REACT:R-MMU-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-SSC-1067659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of hexameric IL-6 receptor (Sus scrofa)
REACT:R-PFA-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Plasmodium falciparum)
REACT:R-XTR-114577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Xenopus tropicalis)
REACT:R-MMU-8952382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 polyubiquitinates RUNX3 (Mus musculus)
RHEA:47129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + deoxycholate => AMP + deoxycholoyl-CoA + diphosphate
RHEA:64445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine
REACT:R-CEL-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)
RHEA:69697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menadiol + NAD(+) => H(+) + menadione + NADH
RHEA:62825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)
REACT:R-DRE-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Danio rerio)
REACT:R-SPO-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Schizosaccharomyces pombe)
REACT:R-CFA-9710354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds cardiolipin (Canis familiaris)
REACT:R-DME-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)
RHEA:54789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide
REACT:R-HSA-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Homo sapiens)
RHEA:57209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + L-cysteinyl-[protein] => S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]
RHEA:25774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-hydroxyasparagine + CO2 + succinate => 2-oxoglutarate + L-asparagine + O2
GO:0000907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphonate dioxygenase activity
GO:0000907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfonate dioxygenase activity
GO:0000907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfonate/alpha-ketoglutarate dioxygenase activity
REACT:R-CFA-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Canis familiaris)
RHEA:53080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:65325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + chrodrimanin A => chrodrimanin B + CoA
REACT:R-DME-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Drosophila melanogaster)
REACT:R-BTA-6788628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dissociate (Bos taurus)
REACT:R-BTA-451757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of nephrin and KIRREL2, KIRREL3 (Bos taurus)
REACT:R-DME-6797627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPG hydrolyses L-Asn to L-Asp (Drosophila melanogaster)
REACT:R-DDI-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Dictyostelium discoideum)
REACT:R-SSC-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Sus scrofa)
REACT:R-SSC-9006873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT binding (Sus scrofa)
RHEA:66089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + oxaloacetate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate
RHEA:23002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)
RHEA:42342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH => 4-(gamma-L-glutamylamino)butanal + H2O + NAD(+)
REACT:R-CFA-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Canis familiaris)
REACT:R-SSC-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)
REACT:R-DRE-166214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion flip-flops to the opposite surface (Danio rerio)
REACT:R-SSC-183089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds and ubiquitinates phosphorylated Sprouty (Sus scrofa)
REACT:R-SSC-5635843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI translocates to the nucleus (Sus scrofa)
REACT:R-CEL-1678843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein translation regulator 4EHP (Caenorhabditis elegans)
EC:3.2.1.84	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan 1,3-alpha-glucosidase"
EC:3.2.1.84	skos:altLabel	"exo-1,3-alpha-glucanase"
EC:3.2.1.84	skos:prefLabel	"glucan 1,3-alpha-glucosidase"
RHEA:67255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonaldehyde + NAD(+) <=> 3-oxopropanoate + 2 H(+) + NADH
REACT:R-RNO-5423653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGST trimers transfer GS from GSH to AFXBO and AFNBO (Rattus norvegicus)
REACT:R-MMU-1482679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)
REACT:R-RNO-9759154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM21 ubiquitinates SQSTM1 (Rattus norvegicus)
REACT:R-HSA-5653622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC35A3 does not exchange UDP-GlcNAc for UMP (Homo sapiens)
REACT:R-BTA-8985973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Bos taurus)
REACT:R-MMU-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Mus musculus)
RHEA:28187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetone + H2O + O2 => H2O2 + methylglyoxal + NH4(+)
RHEA:33535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lanosteryl ester = a carboxylate + H(+) + lanosterol
REACT:R-CFA-193650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR binds to NADE (Canis familiaris)
RHEA:55377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a quinol + O2 => 2 a quinone + 2 H2O
RHEA:18554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-tartrate + NAD(+) => dihydroxyfumarate + H(+) + NADH
REACT:R-RNO-141046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Rattus norvegicus)
RHEA:60135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate
RHEA:59544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose + O2 = H2O2 + N,N'-diacetylchitobiono-1,5-lactone
RHEA:11261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 => H2O2 + NADP(+)
RHEA:55815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine
REACT:R-SSC-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Sus scrofa)
RHEA:18204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
REACT:R-MMU-6800298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF dimer binds MET (Mus musculus)
REACT:R-BTA-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)
RHEA:51467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-1006169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds host cell surface markers (Sus scrofa)
RHEA:64962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + H(+) + phosphate => dTDP + H2O
REACT:R-RNO-378956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone is a heterodimer (Rattus norvegicus)
RHEA:56594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ketone + hydrogen cyanide => a disubstituted aliphatic (S)-hydroxynitrile
REACT:R-RNO-6803545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to phagosomal lumen (Rattus norvegicus)
RHEA:29148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + nitrate + ubiquinol-8 => 2 H(+)(out) + H2O + nitrite + ubiquinone-8
RHEA:42991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> cembrene C + diphosphate
REACT:R-CFA-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Canis familiaris)
RHEA:32293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine => phosphoethanolamine + 3 S-adenosyl-L-methionine
RHEA:34606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphinganine
RHEA:50891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphingoid base 1-phosphate + H2O <=> an N-acyl-sphingoid base + phosphate
REACT:R-BTA-373748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD72 (Bos taurus)
RHEA:47385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetoxyphenol + H2O => acetate + H(+) + hydroquinone
REACT:R-MMU-390595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Troponin-C (Mus musculus)
REACT:R-SSC-9756156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes ATV to ATVL (Sus scrofa)
RHEA:20561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + H(+) = CO2 + glycolaldehyde
RHEA:20561	skos:prefLabel	"hydroxypyruvate decarboxylase"
RHEA:20561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxypyruvate decarboxylase"
RHEA:20561	skos:altLabel	"hydroxypyruvate carboxy-lyase"
RHEA:40510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:30687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
REACT:R-HSA-9614773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBP gene expression (Homo sapiens)
REACT:R-SSC-8939688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) complex binds RUNX2 (Sus scrofa)
RHEA:62368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in)
REACT:R-HSA-5694421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6 dephosphorylates SEC24 (Homo sapiens)
RHEA:46203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-112121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 (Homo sapiens)
REACT:R-MMU-6800200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-HGF to form HGF dimer (Mus musculus)
REACT:R-SSC-1475022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (cytosol) (Sus scrofa)
RHEA:65739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + octyl sulfate <=> CO2 + H(+) + octanal + succinate + sulfate
RHEA:63977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydropyriculariol => AH2 + pyriculariol
GO:0018743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity
REACT:R-BTA-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Bos taurus)
REACT:R-BTA-5362553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTUM releases Hh-Np:GPC5 from the plasma membrane (Bos taurus)
RHEA:19227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine
EC:3.4.21.119	skos:altLabel	"proteinase P"
EC:3.4.21.119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kallikrein 13"
EC:3.4.21.119	skos:altLabel	"PRECE-1"
EC:3.4.21.119	skos:altLabel	"prorenin converting enzyme 1"
EC:3.4.21.119	skos:prefLabel	"kallikrein 13"
EC:3.4.21.119	skos:altLabel	"prorenin-converting enzyme"
EC:3.4.21.119	skos:altLabel	"PRECE"
EC:3.4.21.119	skos:altLabel	"mGK-13"
EC:3.4.21.119	skos:altLabel	"epidermal growth factor-binding protein type B"
RHEA:15849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-ascorbate = 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate
REACT:R-DRE-141431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 associates with the Mad1 kinetochore complex (Danio rerio)
REACT:R-CFA-199032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADCAM1-1 binds Integrin alpha4beta7 (Canis familiaris)
EC:2.7.7.102	skos:altLabel	"PrimPol"
EC:2.7.7.102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA primase AEP"
EC:2.7.7.102	skos:altLabel	"archaeo-eukaryotic primase"
EC:2.7.7.102	skos:prefLabel	"DNA primase AEP"
REACT:R-HSA-4568914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of BLM with SUMO2,3 (Homo sapiens)
RHEA:41966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + H2O2 => butanoyl-CoA + O2
GO:0004989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octopamine receptor activity
GO:0032135	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA insertion binding
GO:0032135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA insertion or deletion binding
GO:0032135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	insertion binding
RHEA:14886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] => ADP-D-ribose + L-arginyl-[protein]
RHEA:27827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-succinyl-L-homoserine => L-homocysteine + succinate
REACT:R-RNO-5696872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates Ub-MOM proteins (Rattus norvegicus)
REACT:R-GGA-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Gallus gallus)
REACT:R-CFA-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Canis familiaris)
RHEA:71674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamine(out) + H(+)(out) <=> glycyl-L-glutamine(in) + H(+)(in)
GO:0103040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldose sugar dehydrogenase activity
REACT:R-DME-9704248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM4 binds CHRM4 antagonists (Drosophila melanogaster)
REACT:R-HSA-2671868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated LEPR Binds STAT3 (Homo sapiens)
RHEA:44673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
REACT:R-XTR-5615637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Xenopus tropicalis)
REACT:R-SSC-140777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Sus scrofa)
REACT:R-HSA-5684882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 is recruited to resected DNA DSBs (Homo sapiens)
REACT:R-HSA-9018542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 coactivator complex binds DLGAP5 gene promoter (Homo sapiens)
RHEA:29157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in) => 2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in)
REACT:R-SSC-8956568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the core TAL1 complex (Sus scrofa)
REACT:R-HSA-9012654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)
RHEA:35428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside
REACT:R-XTR-396996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs binds G-protein Gq (Xenopus tropicalis)
GO:0016831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxy-lyase activity
GO:0016831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decarboxylase activity
REACT:R-SSC-3371359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Sus scrofa)
REACT:R-XTR-5682967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 binds DNA DSBs (Xenopus tropicalis)
REACT:R-CEL-390329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)
REACT:R-MMU-975119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Mus musculus)
REACT:R-SSC-8870332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Sus scrofa)
REACT:R-BTA-8873834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 transports PC from ER membrane to lamellar body membrane (Bos taurus)
REACT:R-RNO-997311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)
REACT:R-CFA-170835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Canis familiaris)
RHEA:25646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,5R)-isomenthone + NADP(+) => (R)-pulegone + H(+) + NADPH
REACT:R-SSC-9036301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Sus scrofa)
RHEA:41239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 = N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine
RHEA:15044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis-D-fructose 2',1:2,1'-dianhydride + H2O <=> inulobiose
RHEA:53301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O => H(+) + N-carbamoyl-D-methionine
RHEA:52162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenylacetaldehyde oxime => (E)-phenylacetaldehyde oxime
RHEA:17759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanamine + CO2 => H(+) + L-methionine
RHEA:34505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-alpha-bisabolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:36180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + CDP-choline => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-XTR-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Xenopus tropicalis)
GO:0034987	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Fc receptor binding
GO:0034987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	immunoglobulin receptor binding
REACT:R-RNO-201821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Rattus norvegicus)
REACT:R-DRE-3791149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Danio rerio)
REACT:R-XTR-3371359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Xenopus tropicalis)
RHEA:50331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-2132074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of surface-bound factor B (Gallus gallus)
REACT:R-RNO-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
RHEA:63848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 = 2 3',4'-dihydroxyaurone + 2 H2O
RHEA:43909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O => D-galactose + sphing-4-enine
REACT:R-SCE-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Saccharomyces cerevisiae)
REACT:R-BTA-8987063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Bos taurus)
RHEA:30710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + pyruvate <=> 4-aminobutanal + L-alanine
REACT:R-RNO-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Rattus norvegicus)
RHEA:33386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + UDP-N-acetyl-alpha-D-glucosamine <=> (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP
RHEA:50007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tetracycline <=> 11a-hydroxytetracycline + H2O + NADP(+)
RHEA:23737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyisourate + H2O => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)
RHEA:69614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kojibiose <=> beta-D-glucose + D-glucose
RHEA:33724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)
RHEA:30145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + octanoate => H2O + octanoyl-CoA
REACT:R-HSA-165027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rev molecules assemble onto the RRE RNA sequence through their ARM sequence (Homo sapiens)
REACT:R-MMU-9646679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded proteins bind vimentin to form aggresome (Mus musculus)
REACT:R-DME-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Drosophila melanogaster)
RHEA:58251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-glutamyl-[protein]
RHEA:60140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetradecanoyl-CoA + CO2 + CoA
RHEA:57067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apionolactone + H2O <=> D-apionate + H(+)
RHEA:20738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-oxobutanoate + CoA => acetyl-CoA + glycine
RHEA:70473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2
RHEA:12036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(imidazol-5-yl)lactate + NAD(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADH
RHEA:65951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 <=> A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O
RHEA:41845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-[ACP] => (2E)-octenoyl-[ACP] + H2O
RHEA:66863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + 4 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate
REACT:R-DRE-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Danio rerio)
REACT:R-CFA-9656891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1SW binds 11cRAL (Canis familiaris)
REACT:R-CFA-446862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)
GO:0044716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GDP phosphatase activity
REACT:R-CFA-3249390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Canis familiaris)
RHEA:51870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylsuberosin + diphosphate => dimethylallyl diphosphate + umbelliferone
REACT:R-DME-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)
GO:0003837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-carbamoyl-beta-alanine amidohydrolase activity
GO:0003837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionase activity
RHEA:35717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S-3S)-versiconal hemiacetal + acetate + H(+) => (2S,3S)-versiconal hemiacetal acetate + H2O
REACT:R-DRE-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Danio rerio)
REACT:R-DRE-5218819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
RHEA:66983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + H2O <=> 2-methylbutanoate + CoA + H(+)
RHEA:35507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic L-alpha-amino acid(out) + L-thyroxine(in) => an aromatic L-alpha-amino acid(in) + L-thyroxine(out)
RHEA:33997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline + butirosin B => gamma-L-glutamyl-butirosin B
REACT:R-HSA-1912409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 mRNA translation controlled by miRNAs (Homo sapiens)
REACT:R-BTA-182993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL) (Bos taurus)
REACT:R-XTR-9708423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1:BACH1:Hemes are transported out of the nucleus (Xenopus tropicalis)
RHEA:24361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + siroheme => Fe(2+) + sirohydrochlorin
RHEA:64422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanyl-L-proline(in) => H(+)(out) + L-alanyl-L-proline(out)
REACT:R-RNO-5610754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Rattus norvegicus)
RHEA:52058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoate + H(+) + hexadecanoate => 12-hexadecanoyloxy-octadecanoate + H2O
RHEA:46125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
RHEA:35431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose)"
RHEA:35431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = cyanidin 3,7-di-O-beta-D-glucoside + vanillate
RHEA:35431	skos:prefLabel	"cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose)"
REACT:R-CEL-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Caenorhabditis elegans)
GO:0099609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule lateral binding
GO:0051911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylviologen-reducing hydrogenase activity
GO:0051911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity
GO:0051911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methanosarcina-phenazine hydrogenase activity
GO:0051911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanophenazine hydrogenase activity
GO:0051911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity
REACT:R-HSA-9692236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMRT1 binds the FOXL2 gene (Homo sapiens)
RHEA:52580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Pb(2+)(in) = ADP + H(+) + Pb(2+)(out) + phosphate
REACT:R-HSA-2731149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-4 binds ACTN1 (Homo sapiens)
RHEA:62548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP
REACT:R-CEL-1606564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Caenorhabditis elegans)
RHEA:55219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + rhizathalene A
REACT:R-XTR-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Xenopus tropicalis)
REACT:R-SSC-5432825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds TLR4:LY96 (Sus scrofa)
REACT:R-HSA-9607224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 (Homo sapiens)
REACT:R-GGA-8852280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds microtubule lattice in interphase cells (Gallus gallus)
REACT:R-HSA-422021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Homo sapiens)
REACT:R-MMU-9706354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of FLT3 (Mus musculus)
REACT:R-PFA-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Plasmodium falciparum)
REACT:R-BTA-8873929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates STARD10 (Bos taurus)
GO:0050085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent mannitol dehydrogenase activity
GO:0050085	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannitol:NADP+ 2-oxidoreductase activity
GO:0050085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannitol 2-dehydrogenase (NADP+) activity
REACT:R-DDI-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Dictyostelium discoideum)
REACT:R-DME-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Drosophila melanogaster)
RHEA:51747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)
REACT:R-MMU-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Mus musculus)
RHEA:67334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinoate + 2 H(+) + NADH => 13-cis-retinal + H2O + NAD(+)
REACT:R-GGA-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Gallus gallus)
REACT:R-HSA-5218824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds FYN (Homo sapiens)
RHEA:32034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-curcumene
REACT:R-MMU-8852317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GTSE1 (Mus musculus)
RHEA:41214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + H(+) + NADH + O2 <=> 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)
RHEA:16106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3S)-3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O
RHEA:51714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-fructose 6-phosphate => keto-D-tagatose 6-phosphate
REACT:R-DME-432642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated TIM transports from the cytosol to the nucleus (Drosophila melanogaster)
GO:0140929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose:sodium symporter activity
GO:0052792	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-galacturonase activity
GO:0052792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-xylogalacturonan hydrolase activity
GO:0017095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan sulfate 6-O-sulfotransferase activity
GO:0017095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan sulphate 6-O-sulphotransferase activity
GO:0017095	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin 6-O-sulfotransferase activity
RHEA:29809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-leucine(in) + phosphate => ATP + H2O + L-leucine(out)
RHEA:45268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-hydroxyechinenone + AH2 + O2 = 4',4'-dihydroxyechinenone + A + H2O
REACT:R-GGA-549129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations into hepatic cells (Gallus gallus)
RHEA:17082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-isoeugenol => H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol
REACT:R-CFA-389826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NADPH + H+ => glycolate + NADP+ (Canis familiaris)
RHEA:67224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA
REACT:R-MMU-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Mus musculus)
RHEA:11693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + NADPH => NADH + NADP(+)
RHEA:29659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine(in) = O-acetyl-L-serine(out)
REACT:R-PFA-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Plasmodium falciparum)
REACT:R-HSA-5637808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)
EC:2.1.1.114	skos:altLabel	"DHHB-Mt"
EC:2.1.1.114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polyprenyldihydroxybenzoate methyltransferase"
EC:2.1.1.114	skos:altLabel	"DHHB O-methyltransferase"
EC:2.1.1.114	skos:altLabel	"dihydroxyhexaprenylbenzoate methyltransferase"
EC:2.1.1.114	skos:altLabel	"DHHB methyltransferase"
EC:2.1.1.114	skos:prefLabel	"polyprenyldihydroxybenzoate methyltransferase"
EC:2.1.1.114	skos:altLabel	"3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase"
REACT:R-BTA-5660662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASC binds Caspase-8 complex (Bos taurus)
RHEA:13454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin => adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate
REACT:R-HSA-5637792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)
REACT:R-BTA-9653585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Farn-Me KRAS4B binds calmodulin (Bos taurus)
RHEA:30708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + pyruvate => 4-aminobutanal + L-alanine
REACT:R-GGA-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Gallus gallus)
RHEA:15729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH
RHEA:15729	skos:altLabel	"mannonic dehydrogenase"
RHEA:15729	skos:altLabel	"D-mannonate oxidoreductase"
RHEA:15729	skos:altLabel	"D-mannonate dehydrogenase"
RHEA:15729	skos:prefLabel	"fructuronate reductase"
RHEA:15729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NAD(+) = H(+) + keto-D-fructuronate + NADH
RHEA:15729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructuronate reductase"
RHEA:11481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)
RHEA:40547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:64320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
RHEA:68439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 <=> (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
REACT:R-DRE-444848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 1 binds relaxin 3 (Danio rerio)
RHEA:53706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-RNO-4088141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PPP2R2A dephosphorylates FOXM1 (Rattus norvegicus)
REACT:R-HSA-389941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP-1 and SHP-2 bind pBTLA (Homo sapiens)
REACT:R-CFA-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Canis familiaris)
REACT:R-SSC-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Sus scrofa)
RHEA:52445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)
REACT:R-GGA-9634584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Gallus gallus)
REACT:R-BTA-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Bos taurus)
RHEA:61897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone C => betaenone A
REACT:R-XTR-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Xenopus tropicalis)
RHEA:71998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + preaspterpenacid acid I
REACT:R-CEL-9661408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Caenorhabditis elegans)
REACT:R-CFA-139919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BIM to mitochondria (Canis familiaris)
REACT:R-CFA-110351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of SMUG1 glycosylase by APEX1 at the AP site (Canis familiaris)
REACT:R-GGA-5624494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 binds p21 RAS:GTP (Gallus gallus)
RHEA:33310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] <=> (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]
REACT:R-BTA-5682794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM22 and ADAM23 (Bos taurus)
REACT:R-HSA-9026411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13(R)-HDPAn-3 translocates from endothelial cell to neutrophil (Homo sapiens)
REACT:R-CEL-390597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Caenorhabditis elegans)
RHEA:37107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(7)-methyl-GMP = N(7)-methylguanosine + phosphate
REACT:R-MMU-2396594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Mus musculus)
REACT:R-SCE-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Saccharomyces cerevisiae)
GO:0033959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine dimer DNA-glycosylase activity
GO:0033959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PD-DNA glycosylase activity
GO:0033959	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endonuclease V activity
GO:0033959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T4-induced UV endonuclease activity
GO:0033959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribodipyrimidine endonucleosidase activity
GO:0033959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleate pyrimidine dimer glycosidase activity
GO:0033959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine dimer DNA glycosylase activity
GO:0033959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity
GO:0001760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity
GO:0001760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminocarboxymuconate-semialdehyde decarboxylase activity
GO:0001760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)
GO:0001760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity
GO:0001760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity
GO:0001760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	picolinic acid decarboxylase activity
GO:0001760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	picolinic acid carboxylase activity
GO:0001760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACMSD activity
GO:0001760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity
RHEA:59277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine => D-glutamine
REACT:R-DRE-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Danio rerio)
REACT:R-MMU-4755411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates IKBKG with SUMO1 (Mus musculus)
REACT:R-DRE-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Danio rerio)
REACT:R-BTA-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
REACT:R-RNO-5324617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:FKBP4:PTGES3 binds HSF1 trimer (Rattus norvegicus)
REACT:R-CFA-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Canis familiaris)
REACT:R-RNO-5357776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)
RHEA:43080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-114306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP:Caspase-3 (Homo sapiens)
REACT:R-PFA-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Plasmodium falciparum)
REACT:R-CFA-5617815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binds RAB3IP (Canis familiaris)
REACT:R-CFA-169895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk's SH3 domain engages C3G (Canis familiaris)
RHEA:46722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA + H2O => (3R)-hydroxyhexanoyl-CoA
RHEA:47719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pregnen-20,21-diol-3-one + NAD(+) <=> 21-hydroxyprogesterone + H(+) + NADH
REACT:R-GGA-139893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Granzyme-B activates BID by cleavage (Gallus gallus)
RHEA:38058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + phytol <=> CDP + H(+) + phytyl phosphate
GO:0009974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zeinoxanthin epsilon hydroxylase activity
GO:0009974	skos:altLabel	"carotene epsilon-monooxygenase"
GO:0009974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin = H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]
GO:0009974	skos:prefLabel	"carotene epsilon-hydroxylase"
GO:0009974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0009974	skos:altLabel	"CYP97C"
GO:0009974	skos:altLabel	"CYP97C1"
GO:0009974	skos:altLabel	"LUT1"
GO:0009974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carotene epsilon-hydroxylase"
REACT:R-RNO-6805640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates KAT6A (Rattus norvegicus)
RHEA:62483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-SPO-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Schizosaccharomyces pombe)
REACT:R-DME-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)
REACT:R-CFA-72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of eIF4E from the inactive eIF4E:4E-BP complex  (Canis familiaris)
REACT:R-HSA-8985275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds to SATB2 (Homo sapiens)
RHEA:39647	skos:prefLabel	"dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase"
RHEA:39647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase"
RHEA:39647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)
REACT:R-BTA-74207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Bos taurus)
GO:0005509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	calcium ion storage activity
GO:0005509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium ion binding
REACT:R-XTR-264689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Xenopus tropicalis)
RHEA:16092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphoethanolamine <=> ethanolamine + phosphate
REACT:R-BTA-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Bos taurus)
RHEA:21997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA
RHEA:39425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA
REACT:R-HSA-4615900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB2 with SUMO3 (Homo sapiens)
REACT:R-HSA-5229203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates histone H2A arginine-30 (H2AR29) (Homo sapiens)
REACT:R-GGA-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Gallus gallus)
REACT:R-MMU-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Mus musculus)
REACT:R-RNO-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Rattus norvegicus)
RHEA:55249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-DRE-2395328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP1, LTBP3 bind TGF-Beta (Danio rerio)
RHEA:24185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2
REACT:R-HSA-75824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin D1 (Homo sapiens)
REACT:R-BTA-8937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Bos taurus)
REACT:R-HSA-177923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sustained activation of SRC kinase by SHP2 (Homo sapiens)
RHEA:48588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin B4
RHEA:49233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] => D-mannose 6-phosphate(in) + L-histidyl-[protein]
REACT:R-BTA-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Bos taurus)
REACT:R-CEL-1482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by HADH (IM) (Caenorhabditis elegans)
RHEA:24113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + O2 => glutathione disulfide + H2O2
GO:0032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTPase activating protein binding
GO:0032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binding
GO:0042349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guiding stereospecific synthesis activity
GO:0042349	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dirigent protein
EC:1.6.8.-	skos:prefLabel	"With a flavin as acceptor"
EC:1.6.8.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a flavin as acceptor"
RHEA:26057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GDP-valienol => GTP + H(+) + valienol 1-phosphate
REACT:R-MMU-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Mus musculus)
RHEA:27932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + AMP + diphosphate + H(+) => (R)-4-phosphopantoate + ATP + beta-alanine
REACT:R-CEL-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Caenorhabditis elegans)
RHEA:50602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] => acetyl-CoA + N-terminal L-seryl-[histone H2A]
RHEA:17148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxy-2,3-dihydrodaidzein + NADP(+) <=> 2'-hydroxydaidzein + 2 H(+) + NADPH
REACT:R-CFA-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Canis familiaris)
REACT:R-HSA-9607304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Homo sapiens)
REACT:R-GGA-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Gallus gallus)
REACT:R-HSA-168895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNP association (Homo sapiens)
REACT:R-GGA-8944250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXV (Gallus gallus)
REACT:R-DME-112437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NELF complex  (Drosophila melanogaster)
RHEA:35837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kanamycin A + NADP(+) => 2'-dehydrokanamycin A + H(+) + NADPH
REACT:R-SCE-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Saccharomyces cerevisiae)
RHEA:10490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + ADP + phosphate => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP
REACT:R-BTA-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Bos taurus)
REACT:R-CFA-168848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAK protein (Canis familiaris)
RHEA:52434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 NH4(+) + pyruvate => (R)-2,3-diaminopropanoate + H(+) + H2O
GO:0047268	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	stachyose synthetase activity
GO:0047268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactinol-raffinose galactosyltransferase activity
GO:0047268	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity
REACT:R-CEL-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Caenorhabditis elegans)
REACT:R-DRE-191972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol is 7alpha-hydroxylated (Danio rerio)
REACT:R-BTA-174121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Securin with Cdc20:APC/C complex (Bos taurus)
REACT:R-XTR-5333678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPNEs bind PL (Xenopus tropicalis)
REACT:R-HSA-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Homo sapiens)
REACT:R-CEL-430311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rsu-1 interacts with Pinch1 (Caenorhabditis elegans)
REACT:R-SCE-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Saccharomyces cerevisiae)
RHEA:24005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:11342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanal + CO2 => 5-guanidino-2-oxopentanoate + H(+)
REACT:R-CFA-6782628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates STAM2:HGS (Canis familiaris)
REACT:R-RNO-378975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follitropin is a heterodimer (Rattus norvegicus)
REACT:R-RNO-1067676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST-2 (Rattus norvegicus)
RHEA:45582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactaro-1,4-lactone => D-galactaro-1,5-lactone
REACT:R-RNO-2029457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIIA with IgG-coated Ag (Rattus norvegicus)
REACT:R-HSA-5683405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP5C dephosphorylates TP53BP1 (Homo sapiens)
RHEA:14735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Ag(+)(out) + H(+) + phosphate => Ag(+)(in) + ATP + H2O
REACT:R-GGA-5362553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTUM releases Hh-Np:GPC5 from the plasma membrane (Gallus gallus)
REACT:R-BTA-1295604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-RAF dissociates from S111/S120 p-SPRY2 (Bos taurus)
REACT:R-HSA-140664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)
REACT:R-MMU-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
REACT:R-BTA-8986083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates ROBO1 (Bos taurus)
REACT:R-MMU-8941618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)
REACT:R-CEL-3928601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)
REACT:R-DME-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Drosophila melanogaster)
RHEA:19200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + NH4(+) <=> adenosine 5'-phosphoramidate + 2 H(+) + sulfate
RHEA:21957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vitexin => H(+) + UDP + vitexin 2''-O-beta-D-glucoside
REACT:R-HSA-6784648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 (1-?) translocates from cytosol to nucleoplasm (Homo sapiens)
REACT:R-RNO-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Rattus norvegicus)
REACT:R-DRE-5682858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate H2AFX (Danio rerio)
REACT:R-DRE-451377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IQGAP1 with nephrin (Danio rerio)
RHEA:46250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2
RHEA:72158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
REACT:R-HSA-9635743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 binds p-T,Y-MAPK (Homo sapiens)
REACT:R-CFA-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Canis familiaris)
REACT:R-CEL-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Caenorhabditis elegans)
GO:0102720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-coenzyme A:acetyl alcohol acetyltransferase activity
REACT:R-HSA-9013021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOB (Homo sapiens)
RHEA:58635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-tetradecanoyl-(2S)-hydroxyglycine <=> glyoxylate + tetradecamide
REACT:R-CFA-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Canis familiaris)
REACT:R-DRE-8864307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Danio rerio)
RHEA:17225	skos:altLabel	"6-oxotetrahydro-nicotinate dehydrogenase"
RHEA:17225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-hydroxynicotinate reductase"
RHEA:17225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] = 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:17225	skos:prefLabel	"6-hydroxynicotinate reductase"
RHEA:17225	skos:altLabel	"6-hydroxynicotinic reductase"
RHEA:17225	skos:altLabel	"HNA reductase"
REACT:R-HSA-1028820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of VAF (virus-activated factor) complex (Homo sapiens)
REACT:R-RNO-5654408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS2 (Rattus norvegicus)
REACT:R-RNO-2997616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Rattus norvegicus)
RHEA:24479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + maleimide <=> H(+) + maleamate
RHEA:51193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH
REACT:R-BTA-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Bos taurus)
REACT:R-MMU-2730842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K associates with phosphorylated GAB2 (Mus musculus)
RHEA:19801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate
RHEA:19801	skos:altLabel	"dephospho-CoA pyrophosphorylase"
RHEA:19801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pantetheine-phosphate adenylyltransferase"
RHEA:19801	skos:altLabel	"phosphopantetheine adenylyltransferase"
RHEA:19801	skos:altLabel	"PPAT"
RHEA:19801	skos:altLabel	"3'-dephospho-CoA pyrophosphorylase"
RHEA:19801	skos:prefLabel	"pantetheine-phosphate adenylyltransferase"
RHEA:19801	skos:altLabel	"dephospho-CoA diphosphorylase"
RHEA:19801	skos:altLabel	"dephospho-coenzyme A pyrophosphorylase"
RHEA:15884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]
REACT:R-SPO-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Schizosaccharomyces pombe)
RHEA:34773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxosteroid + CO2 + NADPH => a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+)
RHEA:25601	skos:prefLabel	"methylthioalkylmalate synthase"
RHEA:25601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O = 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)
RHEA:25601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylthioalkylmalate synthase"
RHEA:25271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-adrenaline + H(+) + S-adenosyl-L-homocysteine => (R)-noradrenaline + S-adenosyl-L-methionine
REACT:R-GGA-2160931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of tight junctions (Gallus gallus)
REACT:R-GGA-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Gallus gallus)
RHEA:63847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + cumene hydroperoxide <=> 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O
RHEA:70520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-octopamine + S-adenosyl-L-methionine => (R)-synephrine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Danio rerio)
REACT:R-DRE-8851436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFHR dimers bind C3b (Danio rerio)
RHEA:65950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O => a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2
RHEA:53491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)
REACT:R-MMU-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Mus musculus)
REACT:R-CFA-416562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGAP binds Plexin-B1 (Canis familiaris)
REACT:R-CFA-8875558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 binds CRK,CRKL (Canis familiaris)
REACT:R-MMU-5362486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Mus musculus)
RHEA:59577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anserine + H2O => beta-alanine + N(pros)-methyl-L-histidine
REACT:R-RNO-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Rattus norvegicus)
RHEA:57653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 => CMP + ganglioside GM1alpha + H(+)
REACT:R-DME-6805059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2:FACT phosphorylates TP53 (Drosophila melanogaster)
REACT:R-BTA-8869568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM1 binds TFAP2A homodimer (Bos taurus)
REACT:R-HSA-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Homo sapiens)
REACT:R-SSC-8934742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRMT1 (Sus scrofa)
RHEA:31735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocholan-24-oyl-CoA + NAD(+) = 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrazolylalaninase activity
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O3-acetyl-L-serine acetate-lyase (adding pyrazole)
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-pyrazolylalanine synthase activity
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BPA-synthase activity
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrazolealanine synthase activity
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-pyrazolylalanine synthase (acetylserine) activity
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-pyrazolealanine synthase activity
GO:0047458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-(1-pyrazolyl)alanine synthase activity
REACT:R-HSA-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Homo sapiens)
REACT:R-HSA-5229194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)
REACT:R-BTA-909738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 bind the common beta chain (Bos taurus)
RHEA:27297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:57779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-6-nitrotoluene + NADH + O2 <=> 4-chloro-3-methylcatechol + NAD(+) + nitrite
RHEA:29066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + formate + H(+) <=> a menaquinol + CO2
REACT:R-DRE-5623513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 stimulates GTPase activity of ARF4 (Danio rerio)
REACT:R-SSC-159843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)
REACT:R-SSC-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Sus scrofa)
RHEA:47068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-5607738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan (Homo sapiens)
RHEA:71880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide
RHEA:63733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan O-beta-D-glucuronoside
REACT:R-RNO-205328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other tyrosine kinases with p-KIT (Rattus norvegicus)
REACT:R-HSA-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
RHEA:63757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavokermesate + UDP-alpha-D-glucose => flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP
REACT:R-CFA-2028735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind WWTR1 (TAZ) (Canis familiaris)
RHEA:31779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-retinyl ester 13-cis isomerohydrolase"
RHEA:31779	skos:prefLabel	"all-trans-retinyl ester 13-cis isomerohydrolase"
RHEA:31779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid + H(+)
REACT:R-HSA-1793182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Homo sapiens)
REACT:R-PFA-376357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp7 associated Lysosome to Plasma membrane transport (Plasmodium falciparum)
REACT:R-XTR-8987039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL20RA (Xenopus tropicalis)
GO:0070700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bone morphogenetic protein receptor binding
GO:0070700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP receptor binding
REACT:R-HSA-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Homo sapiens)
REACT:R-MMU-174255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation multiubiquitinated Cyclin A (Mus musculus)
REACT:R-HSA-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Homo sapiens)
REACT:R-RNO-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Rattus norvegicus)
REACT:R-DRE-211991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclophosphamide is 4-hydroxylated by CYP2B6 (Danio rerio)
GO:0016176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	superoxide-generating NADPH oxidase activator activity
GO:0016176	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neutrophil cytosol factor 2
RHEA:64448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine
RHEA:64448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(4) N-dimethyltransferase"
RHEA:64448	skos:prefLabel	"[histone H3]-lysine(4) N-dimethyltransferase"
REACT:R-HSA-4570554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO1 (Homo sapiens)
REACT:R-GGA-193665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYD88 dissociates (Gallus gallus)
REACT:R-SSC-8874208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Sus scrofa)
RHEA:20794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-lysyl-tRNA(Lys) => ATP + L-lysine + tRNA(Lys)
RHEA:13440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + UDP-alpha-D-glucose <=> 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP
RHEA:23847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + sedoheptulose <=> ADP + D-sedoheptulose 7-phosphate + H(+)
REACT:R-RNO-5635859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU dissociates (Rattus norvegicus)
REACT:R-HSA-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Homo sapiens)
REACT:R-GGA-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Gallus gallus)
RHEA:27448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + xylitol <=> D-xylose + H(+) + NADPH
REACT:R-SSC-140978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex binds FADD (Sus scrofa)
REACT:R-BTA-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Bos taurus)
REACT:R-HSA-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Homo sapiens)
REACT:R-DRE-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Danio rerio)
RHEA:67134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+) => 5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH
REACT:R-MMU-8869606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NAR to yield NAMN (Mus musculus)
GO:0017042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cerebrosidase activity
GO:0017042	skos:altLabel	"phloretin-glucosidase"
GO:0017042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosylceramidase activity
GO:0017042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycosyl ceramide glycosylhydrolase activity
GO:0017042	skos:altLabel	"phlorizin hydrolase"
GO:0017042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycosylceramidase"
GO:0017042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycosyl-N-acylsphingosine glycohydrolase activity
GO:0017042	skos:prefLabel	"glycosylceramidase"
RHEA:16703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + H(+) + NADH => 17alpha-estradiol + NAD(+)
RHEA:63753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kermesate + UDP-alpha-D-glucose => carminate + 2 H(+) + UDP
REACT:R-HSA-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Homo sapiens)
EC:3.4.11.2	skos:prefLabel	"membrane alanyl aminopeptidase"
EC:3.4.11.2	skos:altLabel	"aminopeptidase N"
EC:3.4.11.2	skos:altLabel	"membrane alanine aminopeptidase"
EC:3.4.11.2	skos:altLabel	"microsomal aminopeptidase"
EC:3.4.11.2	skos:altLabel	"amino-oligopeptidase"
EC:3.4.11.2	skos:altLabel	"aminopeptidase M"
EC:3.4.11.2	skos:altLabel	"particle-bound aminopeptidase"
EC:3.4.11.2	skos:altLabel	"membrane aminopeptidase I"
EC:3.4.11.2	skos:altLabel	"peptidase E"
EC:3.4.11.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"membrane alanyl aminopeptidase"
RHEA:10401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + pyruvate => 2-oxoglutaramate + L-alanine
REACT:R-MMU-1604731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP3 (Mus musculus)
REACT:R-RNO-8987266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Rattus norvegicus)
RHEA:14394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine
RHEA:12033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(acyloxy)acyl derivative of bacterial toxin + H2O => 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
REACT:R-BTA-141186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
REACT:R-PFA-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Plasmodium falciparum)
RHEA:12725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-iditol + NAD(+) = H(+) + keto-D-sorbose + NADH
REACT:R-DDI-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)
REACT:R-DRE-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Danio rerio)
REACT:R-BTA-4085033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Bos taurus)
REACT:R-DDI-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Dictyostelium discoideum)
REACT:R-DME-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Drosophila melanogaster)
REACT:R-RNO-5682586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 and PIAS4 are recruited to DNA DSBs (Rattus norvegicus)
RHEA:60740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(-)-citronellal + H2O + NADP(+) = (S)-(-)-citronellate + 2 H(+) + NADPH
REACT:R-DDI-936942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Dictyostelium discoideum)
RHEA:70514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:46063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:19974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + spermine
RHEA:67092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + docosanoate(in) + H2O = ADP + docosanoate(out) + H(+) + phosphate
RHEA:67837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-GGA-5693055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Gallus gallus)
RHEA:40378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
REACT:R-CFA-3215448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Canis familiaris)
GO:0046870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadmium ion binding
GO:0046870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadmium binding
GO:0046870	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	copper/cadmium binding
GO:0046870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd ion binding
RHEA:45462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-SSC-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Sus scrofa)
GO:0052739	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylserine-specific phospholipase A1 activity
GO:0052739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA1A hydrolyses PS to 2-acyl LPS (Homo sapiens)
GO:0052739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylserine 1-acylhydrolase activity
REACT:R-GGA-5694431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Gallus gallus)
GO:0005539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosaminoglycan binding
RHEA:34053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'''-deamino-6'''-hydroxyneomycin C + acetate => 2'''-acetyl-6'''-hydroxyneomycin C + H2O
REACT:R-CEL-8875183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates activated MET (Caenorhabditis elegans)
REACT:R-RNO-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Rattus norvegicus)
RHEA:14063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H(+) + NADH + pyruvate => H2O + N-(carboxymethyl)-D-alanine + NAD(+)
REACT:R-CFA-9009558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds SDC1 (Canis familiaris)
RHEA:23168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coformycin + NADP(+) = 8-oxocoformycin + H(+) + NADPH
RHEA:23168	skos:prefLabel	"8-oxocoformycin reductase"
RHEA:23168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-oxocoformycin reductase"
REACT:R-GGA-390912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds hist (Gallus gallus)
REACT:R-RNO-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Rattus norvegicus)
RHEA:62938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + acetate + H(+) => H2O + N(4)-acetyl-2'-deoxycytidine
RHEA:31988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => baruol
RHEA:22642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + H(+) + NADPH => NADP(+) + sphinganine
REACT:R-DRE-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Danio rerio)
RHEA:59202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + docosanoyl-AMP => ATP + docosanoate + H(+)
REACT:R-HSA-6785245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP11B2 does not oxidise CORST (Homo sapiens)
REACT:R-SSC-5626220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 binds the mother centriole (Sus scrofa)
REACT:R-BTA-508369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Bos taurus)
REACT:R-CFA-5655142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 binds POLH (Canis familiaris)
REACT:R-CFA-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Canis familiaris)
REACT:R-RNO-8854981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 in the RET complex is phosphorylated (Rattus norvegicus)
REACT:R-HSA-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Homo sapiens)
REACT:R-RNO-997309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)
RHEA:42146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine
REACT:R-CFA-2046222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Canis familiaris)
REACT:R-CFA-373087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR6 binds CCL20 ligand (Canis familiaris)
REACT:R-BTA-72127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal B Complex (Bos taurus)
REACT:R-MMU-9692809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the ER membrane (Mus musculus)
RHEA:55953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)
RHEA:34189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O
RHEA:68639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> diphosphate + sabinene
REACT:R-DME-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)
REACT:R-SPO-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Schizosaccharomyces pombe)
REACT:R-RNO-8848713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds BCAR1 (Rattus norvegicus)
REACT:R-SSC-8877620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE2 cleaves EDN1(53-90) (Sus scrofa)
REACT:R-HSA-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Homo sapiens)
RHEA:48642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+)
REACT:R-DDI-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Dictyostelium discoideum)
REACT:R-RNO-350318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at TNLD (429) (Rattus norvegicus)
REACT:R-SSC-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Sus scrofa)
RHEA:69903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(out) + 2 Na(+)(out) = cytidine(in) + 2 Na(+)(in)
RHEA:48992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,3,7-trimethyluric acid 5-monooxygenase"
RHEA:48992	skos:prefLabel	"1,3,7-trimethyluric acid 5-monooxygenase"
RHEA:48992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,7-trimethylurate + H(+) + NADH + O2 = 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)
REACT:R-MMU-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)
REACT:R-SSC-158800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Sus scrofa)
RHEA:57806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2
REACT:R-HSA-2046265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the keratan chain (Homo sapiens)
RHEA:46723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O
REACT:R-DME-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Drosophila melanogaster)
RHEA:56452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"12-epi-hapalindole U synthase"
RHEA:56452	skos:prefLabel	"12-epi-hapalindole U synthase"
RHEA:56452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-hapalindole U
RHEA:66469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O => (17E)-cheilanthenediol
RHEA:72170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurohyodeoxycholate(out) <=> 2 Na(+)(in) + taurohyodeoxycholate(in)
REACT:R-BTA-2203480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC11 binds ligands (Bos taurus)
REACT:R-CFA-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Canis familiaris)
RHEA:72742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) <=> chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)
RHEA:66868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate
RHEA:66660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-glucosylceramide(in) + H2O = ADP + beta-D-glucosylceramide(out) + H(+) + phosphate
REACT:R-GGA-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Gallus gallus)
REACT:R-HSA-187895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal C-ter TLR9 (Homo sapiens)
RHEA:57014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + sulfate => a menaquinone + H2O + sulfite
REACT:R-SSC-9021600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-proteins dissociate from plasma-membrane estrogen receptors (Sus scrofa)
GO:0102582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity
RHEA:19873	skos:altLabel	"steroid sulfatase"
RHEA:19873	skos:altLabel	"Steryl-sulfate sulfohydrolase"
RHEA:19873	skos:altLabel	"arylsulfatase C"
RHEA:19873	skos:prefLabel	"steryl-sulfatase"
RHEA:19873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steryl-sulfatase"
RHEA:19873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate
RHEA:60192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate
REACT:R-CEL-374686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 interaction with Integrins (Caenorhabditis elegans)
RHEA:19869	skos:prefLabel	"glycine N-acyltransferase"
RHEA:19869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine N-acyltransferase"
RHEA:19869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
REACT:R-DRE-629588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Danio rerio)
REACT:R-SSC-2168885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin binds Hemoglobin (Sus scrofa)
REACT:R-HSA-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Homo sapiens)
REACT:R-MMU-202344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)
REACT:R-XTR-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Xenopus tropicalis)
REACT:R-MMU-446083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD151 interacts with BP180 and the integrin alpha 6 subunit (Mus musculus)
REACT:R-MMU-5683801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates BRCA1 (Mus musculus)
REACT:R-DDI-9014641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Dictyostelium discoideum)
REACT:R-DME-5689630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BAP1-interacting complex (Drosophila melanogaster)
GO:0001057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase IV activity
GO:0001057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter
REACT:R-HSA-9011347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO3.1 mRNA translation is positively regulated by MSI1 (Homo sapiens)
REACT:R-XTR-5423672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2, 3A4 oxidise AFB1 to AFNBO (Xenopus tropicalis)
RHEA:54466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-HSA-2514790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by MMP14 (Homo sapiens)
REACT:R-DME-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Drosophila melanogaster)
REACT:R-CEL-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Caenorhabditis elegans)
GO:0033421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCT codon-amino acid adaptor activity
GO:0033421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCU codon-amino acid adaptor activity
GO:0033421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proline tRNA
REACT:R-RNO-159783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)
RHEA:33584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
REACT:R-DME-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Drosophila melanogaster)
RHEA:12602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-2-aminoadipate => 2-oxoadipate + L-glutamate
REACT:R-SSC-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Sus scrofa)
REACT:R-CFA-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Canis familiaris)
REACT:R-RNO-8848087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAP2 recruits STAT3 to PTK6 (Rattus norvegicus)
RHEA:24063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5635843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI translocates to the nucleus (Mus musculus)
REACT:R-DME-8956568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the core TAL1 complex (Drosophila melanogaster)
REACT:R-RNO-1169399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Rattus norvegicus)
REACT:R-SSC-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Sus scrofa)
REACT:R-RNO-8940959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurolysin degrades neurotensin (Rattus norvegicus)
REACT:R-DME-110475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAkt1-mediated phosphorylation inactivates DFOXO (Drosophila melanogaster)
RHEA:38944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate
RHEA:48948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:72205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(in) + hydrogencarbonate(out) => 2 chloride(out) + hydrogencarbonate(in)
RHEA:49550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginyl-[protein] + lactate => H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]
REACT:R-HSA-8983834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Homo sapiens)
EC:2.3.2.36	skos:prefLabel	"RING-type E3 ubiquitin transferase (cysteine targeting)"
EC:2.3.2.36	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RING-type E3 ubiquitin transferase (cysteine targeting)"
EC:2.3.2.36	skos:altLabel	"RING E3 ligase"
RHEA:53826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxotaurolithocholate + H(+) + NADH => NAD(+) + taurochenodeoxycholate
REACT:R-XTR-2559639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV sulfilimine cross-linking by peroxidasin (Xenopus tropicalis)
REACT:R-DRE-879201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bcl-2 and Bcl-XL bind NLRP1 (Danio rerio)
REACT:R-HSA-9681314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Replication transcription complex binds SARS-CoV-1 genomic RNA (Homo sapiens)
RHEA:18271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (S)-3-hydroxyhexanoate + NADP(+)
RHEA:12013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine => ADP + H(+) + thiamine phosphate
RHEA:20725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-saturated-(3S)-3-hydroxyacyl-CoA => a (3E)-enoyl-CoA + H2O
REACT:R-CEL-433089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT can transport taurolithocholate-3-sulphate (Caenorhabditis elegans)
REACT:R-CFA-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Canis familiaris)
REACT:R-HSA-9625324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1 binds SREBF1 gene promoter (Homo sapiens)
REACT:R-BTA-83790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Bos taurus)
REACT:R-MMU-8877153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 binds PC (Mus musculus)
REACT:R-DRE-204947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF migrates to the nucleus (Danio rerio)
RHEA:18289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate = H2O + oxaloacetate
RHEA:18289	skos:prefLabel	"D(-)-tartrate dehydratase"
RHEA:18289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D(-)-tartrate dehydratase"
RHEA:68874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamaldehyde + AMP + diphosphate + NADP(+) => (E)-cinnamate + ATP + H(+) + NADPH
RHEA:66650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	african-3-ene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-HSA-170076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Homo sapiens)
REACT:R-SCE-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)
REACT:R-XTR-9749971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Xenopus tropicalis)
RHEA:71346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-histidine(out) + 2 Na(+)(out) <=> chloride(in) + L-histidine(in) + 2 Na(+)(in)
REACT:R-GGA-9759154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM21 ubiquitinates SQSTM1 (Gallus gallus)
REACT:R-BTA-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Bos taurus)
RHEA:54589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine in 25S rRNA => H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine
RHEA:60620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hexanoyl-sphing-4-enine-1-phosphocholine = choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate
REACT:R-DRE-211207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fragments of DFF45 dissociate from  DFF40 (Danio rerio)
REACT:R-HSA-2023460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity (Homo sapiens)
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate-fructose-6-phosphate 1-phosphotransferase activity
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate-dependent 6-phosphofructose-1-kinase activity
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphofructokinase (pyrophosphate) activity
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inorganic pyrophosphate-dependent phosphofructokinase activity
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inorganic pyrophosphate-phosphofructokinase activity
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate-fructose 6-phosphate phosphotransferase activity
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphate-dependent 6-phosphofructose-1-kinase activity
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphofructokinase (diphosphate) activity
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate-dependent phosphofructo-1-kinase activity
GO:0047334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity
REACT:R-RNO-5205663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)
REACT:R-HSA-190520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Golgi  transport vesicles with microtubules (Homo sapiens)
REACT:R-DME-374680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 trans-homophilic interaction (Drosophila melanogaster)
REACT:R-DRE-749452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gq complex dissociates (Danio rerio)
REACT:R-MMU-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Mus musculus)
REACT:R-RNO-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Rattus norvegicus)
REACT:R-PFA-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Plasmodium falciparum)
REACT:R-BTA-5688786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds RAD23 (Bos taurus)
RHEA:30997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B => O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol
REACT:R-RNO-444691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prokineticin receptors bind prokineticin (Rattus norvegicus)
REACT:R-GGA-8934446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC phosphorylates SHC1 (Gallus gallus)
RHEA:63052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol
RHEA:39643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH = (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)
REACT:R-RNO-2161775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12 oxidises LTA4 to LXA4/B4 (Rattus norvegicus)
REACT:R-GGA-5684273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
REACT:R-SCE-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Saccharomyces cerevisiae)
REACT:R-GGA-176298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of claspin (Gallus gallus)
RHEA:28318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scutellarein + UDP-alpha-D-glucuronate = scutellarin + UDP
RHEA:57217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-dGTP
REACT:R-GGA-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Gallus gallus)
GO:0047252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity
GO:0047252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity
GO:0047252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity
REACT:R-DRE-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Danio rerio)
REACT:R-MMU-1234183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Mus musculus)
RHEA:49919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)
RHEA:72353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + glycocholate(in) => glutarate(in) + glycocholate(out)
RHEA:51515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxamate <=> NH4(+) + oxalate
REACT:R-HSA-427336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. (Homo sapiens)
REACT:R-DRE-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Danio rerio)
RHEA:65594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]
GO:0051449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyrotropin-releasing hormone binding
GO:0051449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyrotropin releasing hormone binding
RHEA:61177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside => CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]
REACT:R-HSA-109380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Homo sapiens)
RHEA:30801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + H(+) + NADH => (3S)-3-hydroxybutanoyl-CoA + NAD(+)
RHEA:30315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,7-dimethylxanthine + H(+) + NADH + O2 = 7-methylxanthine + formaldehyde + H2O + NAD(+)
REACT:R-DME-5693346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CECRI deaminates Ade-Rib to Ino (Drosophila melanogaster)
RHEA:17402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate + H2O
RHEA:31026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene <=> dammara-20,24-diene
RHEA:37612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:42894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyinosine + NH4(+) => 5'-deoxyadenosine + H(+) + H2O
RHEA:68365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol => 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)
RHEA:51719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)
RHEA:56043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
GO:0033886	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellulose-sulfate sulfohydrolase activity
GO:0033886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellulose-polysulfatase activity
RHEA:56222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-RNO-1632843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1 binds DYNLL1,DYNLL2 (Rattus norvegicus)
RHEA:38580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-174425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Rattus norvegicus)
REACT:R-SPO-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Schizosaccharomyces pombe)
REACT:R-HSA-1482827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Homo sapiens)
RHEA:39137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2
REACT:R-RNO-8957241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP73 tetramer translocates to the nucleus (Rattus norvegicus)
GO:0016642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a disulfide as acceptor"
GO:0016642	skos:prefLabel	"With a disulfide as acceptor"
GO:0016642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor
GO:0016642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
REACT:R-RNO-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Rattus norvegicus)
REACT:R-DME-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Drosophila melanogaster)
RHEA:12482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-dioxopentanoate + L-alanine => 5-aminolevulinate + pyruvate
REACT:R-MMU-193143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates TEST to EST17b (Mus musculus)
REACT:R-RNO-443910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 dissociates from integrin alphaIIb beta3 (Rattus norvegicus)
RHEA:26509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenamide + H2O <=> (9Z)-octadecenoate + NH4(+)
REACT:R-CFA-1013013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of GABA B receptor with G protein beta-gamma subunits (Canis familiaris)
REACT:R-MMU-351863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active caspase-8 to the mitochondrial membrane (Mus musculus)
REACT:R-MMU-390597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Mus musculus)
RHEA:24496	skos:altLabel	"acetylcoenzyme A:deacetylvindoline O-acetyltransferase"
RHEA:24496	skos:altLabel	"acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase"
RHEA:24496	skos:altLabel	"acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase"
RHEA:24496	skos:altLabel	"acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase"
RHEA:24496	skos:altLabel	"acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase"
RHEA:24496	skos:altLabel	"17-O-deacetylvindoline-17-O-acetyltransferase"
RHEA:24496	skos:altLabel	"DAT"
RHEA:24496	skos:altLabel	"deacetylvindoline acetyltransferase"
RHEA:24496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deacetylvindoline O-acetyltransferase"
RHEA:24496	skos:prefLabel	"deacetylvindoline O-acetyltransferase"
RHEA:24496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-deacetylvindoline + acetyl-CoA = CoA + vindoline
RHEA:24496	skos:altLabel	"17-O-deacetylvindoline O-acetyltransferase"
REACT:R-HSA-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Homo sapiens)
RHEA:20475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+) => (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein]
REACT:R-GGA-5579018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1(868-1441) binds PAX3(1-319) (Gallus gallus)
REACT:R-DRE-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Danio rerio)
REACT:R-GGA-8847875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF1:GTP binds Golgin TRIP11 (Gallus gallus)
RHEA:11315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrazine + H2O <=> chloride + H(+) + hydroxyatrazine
REACT:R-MMU-3000074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN2 binds RCbl in the circulation (Mus musculus)
REACT:R-RNO-109699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
GO:0106158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + CoA
GO:0106158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPACT activity
GO:0106158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycero-3-phosphocholine acyltransferase activity
GO:0106158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophosphocholine O-acyltransferase activity
GO:0033728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4VCR
GO:0033728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	divinyl chlorophyllide a 8-vinyl-reductase activity
GO:0033728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[4-vinyl]chlorophyllide a reductase activity
GO:0033728	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorophyllide-a:NADP+ oxidoreductase activity
RHEA:44971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetradecanoyl-CoA
GO:0015608	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carbohydrate-importing ATPase activity
GO:0015608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate uptake transporter activity
GO:0015608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate-importing ABC transporter activity
GO:0015608	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sugar transporter
RHEA:70741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine
REACT:R-CFA-4420099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHB  (Canis familiaris)
RHEA:22664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sinapoylglucose--sinapoylglucose O-sinapoyltransferase"
RHEA:22664	skos:prefLabel	"sinapoylglucose--sinapoylglucose O-sinapoyltransferase"
RHEA:22664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-O-(trans-sinapoyl)-beta-D-glucose = 1,2-di-O-sinapoyl beta-D-glucose + D-glucose
REACT:R-MMU-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Mus musculus)
RHEA:31846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA <=> 2-oxepin-2(3H)-ylideneacetyl-CoA
RHEA:54833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-9755306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub UBXN7 is degraded by the 26S proteasome (Canis familiaris)
REACT:R-HSA-1299481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)
REACT:R-DRE-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Danio rerio)
RHEA:59158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]
RHEA:51694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O => prephenate + S-adenosyl-L-methionine
RHEA:72702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylate + H(+) + NADH <=> NAD(+) + propanoate
REACT:R-DDI-165708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated 4EBP1 from eIF4E (Dictyostelium discoideum)
RHEA:57875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2,4-dihydroxycinnamoyl-CoA <=> CoA + umbelliferone
REACT:R-BTA-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Bos taurus)
REACT:R-SCE-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-DRE-8857692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA demethylases demethylate N6-methyladenosine RNA (Danio rerio)
REACT:R-HSA-203862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves pre-miRNA to yield duplex miRNA (Homo sapiens)
RHEA:64897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + UTP => 2 H(+) + 2 phosphate + UMP
REACT:R-RNO-158468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates PARA to PARA-SO4 (Rattus norvegicus)
REACT:R-CFA-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Canis familiaris)
REACT:R-CFA-8852809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPN, CPB2 cleave C3a, C5a (Canis familiaris)
RHEA:68487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxydodecanoate + H(+) <=> CO2 + H2O + undecanal
RHEA:20626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c3] + H2 => 2 Fe(II)-[cytochrome c3] + 2 H(+)
RHEA:13782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)
REACT:R-DRE-9632182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates ESRs (Danio rerio)
REACT:R-BTA-4641206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPOs bind LGRs (Bos taurus)
GO:0005477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate carrier activity
GO:0005477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate secondary active transmembrane transporter activity
RHEA:11546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine
REACT:R-MMU-5423653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGST trimers transfer GS from GSH to AFXBO and AFNBO (Mus musculus)
REACT:R-CFA-9647746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 trimerizes (Canis familiaris)
RHEA:68839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> (6R,7S)-himachala-9,11-diene + diphosphate
RHEA:40800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + H2O => 2-methylpropanoate + CoA + H(+)
REACT:R-HSA-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Homo sapiens)
REACT:R-BTA-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Bos taurus)
REACT:R-DME-9605644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Drosophila melanogaster)
REACT:R-DME-170835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Drosophila melanogaster)
GO:0019973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-13 binding
GO:0019973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-13 binding
RHEA:12539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arogenate <=> CO2 + H2O + L-phenylalanine
REACT:R-CFA-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Canis familiaris)
REACT:R-DRE-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Danio rerio)
REACT:R-BTA-5635845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind CDC73 (Bos taurus)
RHEA:36508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetracosanoyl-CoA + CO2 + CoA
RHEA:23644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]
RHEA:13814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene + H(+) + NADH + O2 => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)
RHEA:22366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate + H(+) + NADH => L-quinate + NAD(+)
REACT:R-HSA-199112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRTAM binds to NECL2 (Homo sapiens)
RHEA:54054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + tau-cadinol => (2E,6E)-farnesyl diphosphate + H2O
RHEA:22419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + H(+) <=> catechol + CO2
GO:0004159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6-dihydrouracil:NAD+ oxidoreductase activity
GO:0004159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dihydrothymine dehydrogenase (NAD+) activity
GO:0004159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrouracil dehydrogenase (NAD(+))"
GO:0004159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine reductase activity
GO:0004159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydropyrimidine dehydrogenase (NAD+) activity
GO:0004159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thymine reductase activity
GO:0004159	skos:prefLabel	"dihydrouracil dehydrogenase (NAD(+))"
GO:0004159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uracil reductase activity
GO:0004159	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dihydrouracil dehydrogenase (NAD+) activity
REACT:R-MMU-443402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)
RHEA:60311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine
RHEA:16977	skos:altLabel	"2-KPCC"
RHEA:16977	skos:altLabel	"NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase"
RHEA:16977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxopropyl-CoM reductase (carboxylating)"
RHEA:16977	skos:prefLabel	"2-oxopropyl-CoM reductase (carboxylating)"
RHEA:16977	skos:altLabel	"NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase"
RHEA:16977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO2 + NADPH
RHEA:64703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH
RHEA:61068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + horhammericine = 19-O-acetylhorhammericine + CoA
REACT:R-SSC-976743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates plasma Factor H-bound C3b (Sus scrofa)
REACT:R-CEL-114558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate Gq (Caenorhabditis elegans)
REACT:R-DRE-9009910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds p-S423,S425-SMAD3 (Danio rerio)
REACT:R-SSC-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)
REACT:R-HSA-109817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)
REACT:R-RNO-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Rattus norvegicus)
REACT:R-XTR-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Xenopus tropicalis)
REACT:R-HSA-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Homo sapiens)
REACT:R-CFA-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Canis familiaris)
REACT:R-BTA-4084912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arresten binds integrin alpha1beta1 (Bos taurus)
RHEA:21132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + xanthine = H2O2 + urate
RHEA:41366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine
RHEA:12092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-acetoin = (R)-acetoin
RHEA:12092	skos:altLabel	"acetylmethylcarbinol racemase"
RHEA:12092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetoin racemase"
RHEA:12092	skos:prefLabel	"acetoin racemase"
RHEA:64240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + octanoyl-CoA = CoA + H(+) + N-octanoylglycine
GO:0008899	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	homoserine O-transsuccinylase activity
GO:0008899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:L-homoserine O-succinyltransferase activity
GO:0008899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homoserine O-succinyltransferase activity
GO:0008899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoserine succinyltransferase activity
RHEA:18843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxopropanoate + H(+) + NADPH => (R)-glycerate + NADP(+)
GO:0043911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine aminotransferase activity
GO:0043911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine transaminase activity
RHEA:10492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphocholine = choline + phosphate
REACT:R-GGA-2161293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin forms aggregate globules (Gallus gallus)
REACT:R-DRE-1475422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPS is phosphorylated by cGMP-dependant protein kinase II (Danio rerio)
RHEA:15255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + itaconate => cis-aconitate + H(+)
RHEA:51912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate
RHEA:17403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxy-2-hydroxy-cis,cis-muconate + H2O => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
REACT:R-GGA-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Gallus gallus)
RHEA:18365	skos:prefLabel	"D-malate dehydrogenase (decarboxylating)"
RHEA:18365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-malate dehydrogenase (decarboxylating)"
RHEA:18365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate + NAD(+) = CO2 + NADH + pyruvate
EC:7.2.-.-	skos:prefLabel	"Catalysing the translocation of inorganic cations"
EC:7.2.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Catalysing the translocation of inorganic cations"
GO:0050840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adhesive extracellular matrix constituent
GO:0050840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular matrix constituent binding
GO:0050840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular matrix binding
RHEA:65783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:55520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nerylneryl diphosphate synthase"
RHEA:55520	skos:altLabel	"CPT2"
RHEA:55520	skos:prefLabel	"nerylneryl diphosphate synthase"
RHEA:55520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + nerylneryl diphosphate
REACT:R-HSA-2769008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants bind DLL1  (Homo sapiens)
REACT:R-CFA-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Canis familiaris)
REACT:R-CEL-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Caenorhabditis elegans)
REACT:R-PFA-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Plasmodium falciparum)
RHEA:18610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + N(2)-acetyl-L-ornithine => H(+) + N(2)-acetyl-L-citrulline + phosphate
RHEA:34498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
REACT:R-GGA-9009065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXA1 and GATA3 bind to CCND1 promoter (Gallus gallus)
REACT:R-DRE-2396029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-3 binds integrins (Danio rerio)
REACT:R-RNO-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Rattus norvegicus)
REACT:R-SSC-8987042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)
GO:0102041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase
REACT:R-HSA-9670433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
REACT:R-RNO-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Rattus norvegicus)
RHEA:40944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate
REACT:R-HSA-139898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 activates BID by cleavage (Homo sapiens)
RHEA:50066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + H2O + taurochenodeoxycholate(in)
REACT:R-PFA-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Plasmodium falciparum)
REACT:R-XTR-3000074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN2 binds RCbl in the circulation (Xenopus tropicalis)
REACT:R-HSA-8875490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind ubiquitinated MET (Homo sapiens)
RHEA:60557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(35) in tRNA(Tyr) => pseudouridine(35) in tRNA(Tyr)
GO:0102447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnetin 3'-O-methyltransferase activity
RHEA:63493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menadione + NADPH => menadiol + NADP(+)
RHEA:53175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-SSC-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Sus scrofa)
REACT:R-CFA-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Canis familiaris)
REACT:R-CFA-5676598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)
REACT:R-DRE-426522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nonendonucleolytic RISC binds exactly matching target RNAs (Danio rerio)
REACT:R-RNO-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Rattus norvegicus)
RHEA:46696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-5666088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP recruits DAIPH2-3 to endosomes (Danio rerio)
REACT:R-MMU-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)
REACT:R-SSC-6799202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Sus scrofa)
REACT:R-HSA-110380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of LIG3:XRCC1 complex from the BER site (Homo sapiens)
REACT:R-BTA-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Bos taurus)
REACT:R-RNO-6806957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET receptor dimerizes (Rattus norvegicus)
RHEA:61471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in tRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
RHEA:27393	skos:prefLabel	"dichlorochromopyrrolate synthase"
RHEA:27393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dichlorochromopyrrolate synthase"
RHEA:27393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = chromopyrrolate + H(+) + 2 H2O + NH4(+)
RHEA:27393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)
RHEA:67999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-1,2-dichloroethene + AH2 <=> A + chloride + chloroethene + H(+)
REACT:R-XTR-6809006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Xenopus tropicalis)
REACT:R-CEL-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Caenorhabditis elegans)
RHEA:66896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-445448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHIP binds Hedgehog (Rattus norvegicus)
RHEA:53748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP
REACT:R-HSA-5663124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene (Homo sapiens)
RHEA:10625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + CO2 + H2O + NH4(+) => 2 ADP + carbamoyl phosphate + 3 H(+) + phosphate
REACT:R-DME-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Drosophila melanogaster)
RHEA:67839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-CEL-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Caenorhabditis elegans)
REACT:R-BTA-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Bos taurus)
REACT:R-HSA-6805470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates TP53 (Homo sapiens)
REACT:R-HSA-5617457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB1 mRNA is translated (Homo sapiens)
REACT:R-DDI-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Dictyostelium discoideum)
REACT:R-MMU-9638046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY3:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)
REACT:R-SSC-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Sus scrofa)
REACT:R-DRE-75879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Danio rerio)
RHEA:48596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol + H(+)
REACT:R-RNO-2395873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)
RHEA:17489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)
RHEA:17489	skos:prefLabel	"phthalate 4,5-dioxygenase"
RHEA:17489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phthalate 4,5-dioxygenase"
RHEA:17489	skos:altLabel	"phthalate dioxygenase"
RHEA:17489	skos:altLabel	"PDO"
REACT:R-HSA-9700142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds FRS2 (Homo sapiens)
REACT:R-CFA-8866321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL binds APOC1 and APOC4 (Canis familiaris)
RHEA:22352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-lysine = cadaverine + CO2
RHEA:22352	skos:altLabel	"L-lysine carboxy-lyase"
RHEA:22352	skos:prefLabel	"lysine decarboxylase"
RHEA:22352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine decarboxylase"
RHEA:35462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + NAD(+) <=> cholest-5-en-3-one + H(+) + NADH
RHEA:68564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin
RHEA:12054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + trichodiene => (2E,6E)-farnesyl diphosphate
REACT:R-MMU-8963851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 dissociates from GC (Mus musculus)
RHEA:34049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'''-deamino-6'''-oxoneomycin C + H2O2 => 6'''-deamino-6'''-hydroxyneomycin C + O2
GO:0031823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 1D receptor binding
GO:0031823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1D serotonin receptor binding
GO:0031823	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1D serotonin receptor ligand
REACT:R-HSA-399952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIMK-1 by PAK (Homo sapiens)
REACT:R-DRE-5651739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Danio rerio)
REACT:R-CFA-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Canis familiaris)
REACT:R-DME-434989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA7A binds to PLXNC1 (Drosophila melanogaster)
REACT:R-MMU-210290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHIP (Mus musculus)
RHEA:49264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-[(E)-caffeoyl]-shikimate + H2O = (E)-caffeate + H(+) + shikimate
REACT:R-HSA-9653893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF4, CEBPB, and ATF3 bind the CHAC1 promoter (Homo sapiens)
REACT:R-HSA-9629369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to thymine glycol (Homo sapiens)
RHEA:57065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apionolactone + H2O => D-apionate + H(+)
RHEA:28768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylnitronate + O2 => acetaldehyde + chemical entity + H(+) + nitrite
RHEA:60937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5660662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASC binds Caspase-8 complex (Sus scrofa)
REACT:R-SSC-508308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Sus scrofa)
REACT:R-HSA-167056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC binds to the activated TrkA receptor (Homo sapiens)
REACT:R-XTR-1793207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses C4S/C6S chains (Xenopus tropicalis)
RHEA:60873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP
REACT:R-MMU-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Mus musculus)
RHEA:54729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]
RHEA:43445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-ditetradecanoyl-sn-glycerol + ATP => 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)
GO:0016015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	morphogen activity
REACT:R-MMU-2130393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex along Golgi to TGN (Mus musculus)
GO:0005315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic phosphate transmembrane transporter activity
REACT:R-GGA-8877620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE2 cleaves EDN1(53-90) (Gallus gallus)
REACT:R-BTA-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Bos taurus)
REACT:R-RNO-9024766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Rattus norvegicus)
RHEA:51164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
RHEA:31180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxydodecanoyl-CoA + NAD(+) => 3-oxododecanoyl-CoA + H(+) + NADH
RHEA:32780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Co(2+)(out) + H2O => ADP + Co(2+)(in) + H(+) + phosphate
REACT:R-DME-4641134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds AXIN (Drosophila melanogaster)
RHEA:67153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]
REACT:R-HSA-3240783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)
REACT:R-RNO-158145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Rattus norvegicus)
RHEA:45437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate
REACT:R-CEL-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Caenorhabditis elegans)
GO:0030794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity
GO:0030794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-coclaurine-N-methyltransferase activity
REACT:R-DME-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Drosophila melanogaster)
RHEA:62255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + Zn(2+)(out) <=> 2 hydrogencarbonate(in) + Zn(2+)(in)
REACT:R-CFA-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Canis familiaris)
REACT:R-DRE-420265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind IAPP(34-70) (Danio rerio)
RHEA:36240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-2-acyl-sn-glycerol + phosphate
RHEA:54905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH => (9Z)-hexadecenoyl-[ACP] + NAD(+)
RHEA:69305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-glucotropeolin + H2O => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
REACT:R-GGA-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Gallus gallus)
REACT:R-SPO-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Schizosaccharomyces pombe)
REACT:R-CFA-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Canis familiaris)
EC:1.3.4.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a disulfide as acceptor"
EC:1.3.4.-	skos:prefLabel	"With a disulfide as acceptor"
REACT:R-HSA-3134800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING dimerization (Homo sapiens)
REACT:R-MMU-8854604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D16 accelerates GTP hydrolysis by RAB4A (Mus musculus)
REACT:R-CEL-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Caenorhabditis elegans)
REACT:R-DRE-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Danio rerio)
RHEA:27478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + neopinone + succinate
REACT:R-DDI-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Dictyostelium discoideum)
REACT:R-SCE-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Saccharomyces cerevisiae)
RHEA:46740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrodesmosterol + H(+) + NADPH = desmosterol + NADP(+)
RHEA:68975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + sn-glycerol 3-phosphate <=> AH2 + dihydroxyacetone phosphate
RHEA:48295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + GDP-beta-L-fucose <=> ganglioside Fuc-GM1 + GDP + H(+)
REACT:R-DDI-8862152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Dictyostelium discoideum)
REACT:R-DRE-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Danio rerio)
REACT:R-SSC-870437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) deubiquitinates SMAD4 (Sus scrofa)
RHEA:53244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5610723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind SUFU (Canis familiaris)
REACT:R-HSA-9700121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN,MDK):PTPRZ oligomerizes (Homo sapiens)
RHEA:15082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + CoA => acetyl-CoA + ADP + phosphate
REACT:R-HSA-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Homo sapiens)
RHEA:61974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-DRE-8849882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-4 bind reticulon 3 (Danio rerio)
REACT:R-GGA-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Gallus gallus)
RHEA:69348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-1-propenyl-L-cysteine sulfoxide = (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate
REACT:R-DME-5654620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
RHEA:42527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(1911/1915/1917) in 23S rRNA <=> pseudouridine(1911/1915/1917) in 23S rRNA
RHEA:62725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide C + FADH2
REACT:R-HSA-9026757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT hydrolyses MCTR1 to MCTR2 (Homo sapiens)
REACT:R-BTA-77303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Bos taurus)
RHEA:65340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-threonyl-[protein] = CoA + O-acetyl-L-threonyl-[protein]
EC:3.2.1.153	skos:altLabel	"beta-(2-1)-D-fructan fructohydrolase"
EC:3.2.1.153	skos:altLabel	"beta-(2-1)-linkage-specific fructan-beta-fructosidase"
EC:3.2.1.153	skos:altLabel	"1-FEH w1"
EC:3.2.1.153	skos:altLabel	"beta-(2-1)fructan exohydrolase"
EC:3.2.1.153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructan beta-(2,1)-fructosidase"
EC:3.2.1.153	skos:altLabel	"1-fructan exohydrolase"
EC:3.2.1.153	skos:altLabel	"1-FEH II"
EC:3.2.1.153	skos:altLabel	"1-FEH w2"
EC:3.2.1.153	skos:prefLabel	"fructan beta-(2,1)-fructosidase"
EC:3.2.1.153	skos:altLabel	"beta-(2,1)-D-fructan fructohydrolase"
EC:3.2.1.153	skos:altLabel	"inulinase"
REACT:R-GGA-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Gallus gallus)
GO:0015382	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium:sulfate cotransporter activity
GO:0015382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:sulfate symporter activity
GO:0015382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:sulphate symporter activity
REACT:R-DRE-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Danio rerio)
REACT:R-XTR-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Xenopus tropicalis)
REACT:R-DRE-216069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaDbeta2 with fibrin (Danio rerio)
REACT:R-RNO-109863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK3:MAP2K1 (Rattus norvegicus)
REACT:R-CEL-354087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
REACT:R-DRE-9020251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Danio rerio)
RHEA:63141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoyl-taurine => taurine + tetracosanoate
REACT:R-GGA-5362427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds GPC5 (Gallus gallus)
REACT:R-GGA-5654622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)
RHEA:55566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydoxytryptamine 4-phosphate + ADP + H(+) => 4-hydroxytryptamine + ATP
RHEA:25760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate => diphosphate + ent-isokaurene
REACT:R-DME-193533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Drosophila melanogaster)
REACT:R-BTA-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Bos taurus)
REACT:R-CFA-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Canis familiaris)
RHEA:49037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-pluviatolide + S-adenosyl-L-methionine => (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-5658195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol (Homo sapiens)
GO:0050241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrroline-2-carboxylate reductase activity
GO:0050241	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-proline:NAD(P)+ 2-oxidoreductase activity
GO:0050241	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta1-pyrroline-2-carboxylate reductase activity
REACT:R-HSA-1222583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MscR reduces nitrosomycothiol to ammonia (Homo sapiens)
RHEA:67803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate
RHEA:68934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + NADP(+) + octanal => ATP + H(+) + NADPH + octanoate
RHEA:14506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + thiosulfate => glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite
REACT:R-RNO-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Rattus norvegicus)
RHEA:71226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + taurine(out) <=> chloride(in) + 2 Na(+)(in) + taurine(in)
REACT:R-DRE-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Danio rerio)
RHEA:46227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H2O <=> (E)-ferulate + CoA + H(+)
GO:0035325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Toll-like receptor binding
GO:0035325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR binding
REACT:R-DRE-6799246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates TP53 (Danio rerio)
REACT:R-CFA-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Canis familiaris)
REACT:R-SSC-1855200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Sus scrofa)
REACT:R-BTA-983142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of peptide loading complex (PLC) (Bos taurus)
REACT:R-CEL-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)
REACT:R-CFA-6811479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 recruits EP300 to TP53 (Canis familiaris)
REACT:R-BTA-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Bos taurus)
REACT:R-SSC-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Sus scrofa)
REACT:R-CFA-5668404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFA binds TNFR2 (Canis familiaris)
REACT:R-RNO-8987104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Rattus norvegicus)
REACT:R-RNO-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Rattus norvegicus)
RHEA:68625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]
RHEA:61751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rubusoside + UDP-alpha-D-glucose <=> H(+) + stevioside + UDP
REACT:R-RNO-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Rattus norvegicus)
REACT:R-GGA-5638004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 binds ARL3:GTP:UNC119B (Gallus gallus)
REACT:R-SSC-936947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Sus scrofa)
REACT:R-XTR-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Xenopus tropicalis)
REACT:R-CFA-209063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Canis familiaris)
REACT:R-CEL-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Caenorhabditis elegans)
RHEA:25039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + O-phospho-L-seryl-tRNA(Sec) => ATP + L-seryl-tRNA(Sec)
REACT:R-RNO-8848077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAP2 (Rattus norvegicus)
RHEA:66991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanoate + ATP + CoA <=> 4-methylpentanoyl-CoA + AMP + diphosphate
RHEA:50577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]
RHEA:17517	skos:prefLabel	"long-chain-fatty-acyl-glutamate deacylase"
RHEA:17517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(long-chain-fatty-acyl)-L-glutamate = a long-chain fatty acid + L-glutamate
RHEA:17517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-fatty-acyl-glutamate deacylase"
RHEA:17517	skos:altLabel	"long-chain aminoacylase"
REACT:R-MMU-5626681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of transition zone proteins (Mus musculus)
RHEA:42571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-p-cumate + O2 <=> 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)
REACT:R-MMU-2468041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Mus musculus)
REACT:R-DRE-9702354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCA antibodies (Danio rerio)
REACT:R-SSC-8987202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)
RHEA:19363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate
REACT:R-RNO-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Rattus norvegicus)
REACT:R-DDI-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Dictyostelium discoideum)
RHEA:16181	skos:altLabel	"flavonol 7-methyltransferase"
RHEA:16181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-methylquercetin 7-O-methyltransferase"
RHEA:16181	skos:altLabel	"3-methylquercitin 7-O-methyltransferase"
RHEA:16181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:16181	skos:prefLabel	"3-methylquercetin 7-O-methyltransferase"
RHEA:16181	skos:altLabel	"flavonol 7-O-methyltransferase"
RHEA:16181	skos:altLabel	"7-OMT"
GO:0008256	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein-L-histidine N-pros-phosphotransferase activity
GO:0008256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:protein-L-histidine Npi-phosphotransferase activity
GO:0008256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-histidine pros-kinase activity
GO:0008256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein histidine pros-kinase activity
RHEA:33108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + gamma-muurolene
REACT:R-HSA-9672174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of PDGFRA extracellular domain mutants (Homo sapiens)
REACT:R-MMU-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Mus musculus)
REACT:R-HSA-391867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fyn binds NCAM1 (Homo sapiens)
RHEA:62389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n) + H2O => [(1->2)-beta-D-glucosyl](n-2) + sophorose
RHEA:49342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin
REACT:R-DRE-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Danio rerio)
REACT:R-CFA-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Canis familiaris)
REACT:R-XTR-6785126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA core complex assembles at DNA interstrand crosslinks (ICLs) (Xenopus tropicalis)
REACT:R-HSA-201475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
REACT:R-DME-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Drosophila melanogaster)
RHEA:35940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brevianamide F + dimethylallyl diphosphate => diphosphate + tryprostatin B
RHEA:61270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxohexanoate + H2O2 + NH4(+) => H2O + L-2-aminohexanoate + O2
RHEA:22883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arogenate <=> L-glutamate + prephenate
RHEA:22955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octanedioyl-CoA <=> (2E)-octenedioyl-CoA + H2O2
REACT:R-SSC-1676162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Sus scrofa)
RHEA:34559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11beta-hydroxypentalenate + NAD(+) = 1-deoxy-11-oxopentalenate + H(+) + NADH
RHEA:34559	skos:prefLabel	"1-deoxy-11beta-hydroxypentalenate dehydrogenase"
RHEA:34559	skos:altLabel	"1-deoxy-11beta-hydroxypentalenic acid dehydrogenase"
RHEA:34559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-deoxy-11beta-hydroxypentalenate dehydrogenase"
REACT:R-CFA-3364026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SET1 complex trimethylates H3K4 at the MYC gene (Canis familiaris)
RHEA:31682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prosolanapyrone II <=> H2O2 + prosolanapyrone III
RHEA:37003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA
RHEA:37241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + uridine 2'-phosphate => 2',3'-cyclophospho-UMP + H2O
REACT:R-DME-432909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Plectin with Integrin beta 4 (Drosophila melanogaster)
REACT:R-DDI-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Dictyostelium discoideum)
REACT:R-RNO-3222006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STK11 (LKB1) phosphorylates NUAK1 (Rattus norvegicus)
REACT:R-SSC-420586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Necl-2 trans heterodimer interaction (Sus scrofa)
RHEA:31739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4'-hydroxyisoflavone + S-adenosyl-L-methionine = a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:31739	skos:prefLabel	"isoflavone 4'-O-methyltransferase"
RHEA:31739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoflavone 4'-O-methyltransferase"
RHEA:53623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-spiroviolene + diphosphate
RHEA:21041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-SSC-182988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty lures CBL away from EGFR (Sus scrofa)
RHEA:29761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanoate(out) => octanoate(in)
REACT:R-SPO-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Schizosaccharomyces pombe)
RHEA:11377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + NADP(+) => 4,21-dehydrogeissoschizine + NADPH
REACT:R-SSC-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Sus scrofa)
REACT:R-RNO-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Rattus norvegicus)
REACT:R-XTR-5358579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase delta polymerizes DNA across single stranded gap (Xenopus tropicalis)
RHEA:17795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-alanine + tRNA(Thr) => H2O + L-alanyl-tRNA(Thr)
RHEA:70850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-cysteine(out) + Na(+)(out) <=> L-arginine(out) + L-cysteine(in) + Na(+)(in)
REACT:R-GGA-209087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBA is phosphorylated by Phospho IKKB kinase (Gallus gallus)
REACT:R-CEL-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Caenorhabditis elegans)
REACT:R-RNO-8985900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Rattus norvegicus)
REACT:R-HSA-9709454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR binds EPOR agonists (Homo sapiens)
REACT:R-BTA-9696266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds effectors (Bos taurus)
RHEA:57205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + L-lysyl-[protein] => N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]
GO:0047269	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity
GO:0047269	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity
GO:0047269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity
GO:0047269	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity
REACT:R-RNO-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Rattus norvegicus)
REACT:R-DRE-1369017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in muscle cells (Danio rerio)
REACT:R-RNO-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Rattus norvegicus)
RHEA:30569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate => 5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate
RHEA:38885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + AMP + diphosphate => a fatty acid + ATP + CoA
GO:0030352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
REACT:R-RNO-2465890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR2 binds collagen type I, II, III, V, X fibrils (Rattus norvegicus)
REACT:R-HSA-9638078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)
REACT:R-HSA-3788745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL8 promoter (Homo sapiens)
RHEA:21431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate <=> H(+) + pyruvate + sulfite
GO:0044389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conjugating protein ligase binding
GO:0044389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E3 protein ligase binding
GO:0044389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein ligase binding
REACT:R-SSC-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Sus scrofa)
REACT:R-MMU-2028598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS1 (Mus musculus)
REACT:R-XTR-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Xenopus tropicalis)
REACT:R-XTR-159819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Xenopus tropicalis)
REACT:R-CFA-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Canis familiaris)
RHEA:53237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmosterol + O2 + reduced [NADPH--hemoprotein reductase] => (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:45249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) => butanoate(in)
RHEA:31810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> alpha-guaiene + diphosphate
RHEA:39946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA
RHEA:59494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate => (2E)-geranyl diphosphate + L-tryptophyl-[protein]
REACT:R-BTA-190268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to Klotho-bound FGF23 (Bos taurus)
REACT:R-SSC-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)
REACT:R-CFA-9793680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
REACT:R-DME-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Drosophila melanogaster)
RHEA:30406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(3+)(out) + L-ascorbate(in) <=> Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)
REACT:R-DRE-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Danio rerio)
REACT:R-SSC-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Sus scrofa)
REACT:R-MMU-5662660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopachrome is transformed to DHICA by DCT (Mus musculus)
REACT:R-BTA-2681667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Bos taurus)
RHEA:56994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-costunolide + H2O => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)
REACT:R-MMU-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Mus musculus)
RHEA:71711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-tyrosylglycine(out) = H(+)(in) + L-tyrosylglycine(in)
RHEA:71571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(L-seryl)-dTMP in DNA + H(+) = 5-aminoethoxy-methyl-dUMP in DNA + CO2
REACT:R-DME-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Drosophila melanogaster)
RHEA:52175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5624492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK phosphorylates p21 RAF1 on S338 (Gallus gallus)
REACT:R-DRE-5621366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to p-Y65,Y76-FCER1G (Danio rerio)
REACT:R-GGA-140736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Gallus gallus)
RHEA:66335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate(out) <=> L-aspartate(in)
REACT:R-DRE-5610746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI3 (Danio rerio)
RHEA:37563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
RHEA:61119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Mus musculus)
REACT:R-SPO-9018785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds GTP (Schizosaccharomyces pombe)
RHEA:13093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP
REACT:R-SSC-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)
GO:0004340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose kinase activity
GO:0004340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucokinase (phosphorylating)
GO:0004340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-glucose 6-phosphotransferase activity
GO:0004340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase activity
REACT:R-MMU-5099886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binding to FZD promotes PRICKLE1 degradation (Mus musculus)
REACT:R-SSC-9617067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Sus scrofa)
REACT:R-MMU-8847968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN binds FRK (Mus musculus)
REACT:R-XTR-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Xenopus tropicalis)
REACT:R-XTR-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Xenopus tropicalis)
REACT:R-HSA-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Homo sapiens)
REACT:R-HSA-9682258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 binds nsp12 (Homo sapiens)
RHEA:22467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]
RHEA:71728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + fumarate(in) => citrate(in) + fumarate(out)
REACT:R-HSA-4088152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXM1 stimulates CDC25A transcription (Homo sapiens)
RHEA:45775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannosyl](n) + phosphate <=> [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate
GO:0008428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease inhibitor activity
REACT:R-CFA-9635743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 binds p-T,Y-MAPK (Canis familiaris)
REACT:R-CEL-751027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Caenorhabditis elegans)
REACT:R-HSA-8964274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12) binds BTK (Homo sapiens)
REACT:R-SPO-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Schizosaccharomyces pombe)
RHEA:24583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol 6-phosphate + H2O <=> D-sorbitol + phosphate
REACT:R-SSC-8851919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 and GRB2 (Sus scrofa)
EC:2.3.2.29	skos:prefLabel	"aspartate/glutamate leucyltransferase"
EC:2.3.2.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate/glutamate leucyltransferase"
RHEA:36285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + formaldehyde + H2O + NADP(+) => 1,7-dimethylxanthine + H(+) + NADPH + O2
REACT:R-DRE-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Danio rerio)
REACT:R-DRE-114259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase‑9 to caspase‑9 (Danio rerio)
REACT:R-SPO-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Schizosaccharomyces pombe)
RHEA:45057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxynogalonate + O2 => H(+) + H2O + nogalonate
RHEA:43376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyinosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
RHEA:43205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:48917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b => CMP + ganglioside GD1c + H(+)
REACT:R-RNO-351210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Rattus norvegicus)
RHEA:20451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+) => 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2
GO:0043734	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	AlkB
GO:0043734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-N1-methyladenine dioxygenase activity
GO:0043734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative demethylation of 1-meA damaged DNA by ALKBH2 (Homo sapiens)
GO:0043734	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-ketoglutarate-dependent dioxygenase
GO:0043734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative demethylation of 1-meA damaged DNA By ALKBH3 (Homo sapiens)
REACT:R-DME-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Drosophila melanogaster)
RHEA:41094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine
RHEA:51503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate
RHEA:41263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prostaglandin A1 = 15-oxo-prostaglandin A1 + H(+) + NADH
RHEA:58205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)
REACT:R-DRE-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Danio rerio)
REACT:R-RNO-1604368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of bound proMMP2 (Rattus norvegicus)
REACT:R-RNO-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Rattus norvegicus)
REACT:R-RNO-3108209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO1 (Rattus norvegicus)
REACT:R-HSA-9713785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-cancer drugs generate DNA interstrand crosslinks (Homo sapiens)
RHEA:58041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)
RHEA:17331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-camphor + H(+) + NADH => (1R,2S,4R)-borneol + NAD(+)
REACT:R-XTR-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Xenopus tropicalis)
REACT:R-GGA-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Gallus gallus)
RHEA:63484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]
REACT:R-BTA-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Bos taurus)
REACT:R-HSA-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Homo sapiens)
REACT:R-CEL-176631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Caenorhabditis elegans)
RHEA:53520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:10108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine
RHEA:10108	skos:prefLabel	"salutaridine reductase (NADPH)"
RHEA:10108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salutaridine reductase (NADPH)"
RHEA:55373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl (-)-jasmonate => H(+) + jasmonate + methanol
GO:0050449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)
GO:0050449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	casbene synthase activity
GO:0050449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	casbene synthetase activity
GO:0050449	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)
RHEA:62197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + propan-2-ol => acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-BTA-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Bos taurus)
RHEA:39814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Mus musculus)
RHEA:10164	skos:prefLabel	"phosphopyruvate hydratase"
RHEA:10164	skos:altLabel	"enolase"
RHEA:10164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate
RHEA:10164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphopyruvate hydratase"
RHEA:10164	skos:altLabel	"2-phosphoglycerate dehydratase"
RHEA:25799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + L-glutamate
REACT:R-BTA-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Bos taurus)
RHEA:12548	skos:prefLabel	"xanthoxin dehydrogenase"
RHEA:12548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xanthoxin dehydrogenase"
RHEA:12548	skos:altLabel	"xanthoxin oxidase"
RHEA:12548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis,4-trans-xanthoxin + NAD(+) = 2-cis-(+)-abscisic aldehyde + H(+) + NADH
REACT:R-DRE-8964619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds ARHGEF6 (Danio rerio)
REACT:R-DRE-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Danio rerio)
RHEA:59331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,5-lactone + H2O <=> D-xylonate + H(+)
REACT:R-HSA-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)
RHEA:12932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + acetyl-CoA + H2O <=> (2R)-homocitrate + CoA + H(+)
REACT:R-HSA-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Homo sapiens)
REACT:R-SSC-9634584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Sus scrofa)
REACT:R-SSC-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Sus scrofa)
RHEA:33679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine
REACT:R-SSC-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Sus scrofa)
RHEA:31135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate = 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate
GO:0140328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	floppase activity (cytosolic to exoplasmic leaftlet)
GO:0140328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	floppase activity
REACT:R-MMU-2186607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Mus musculus)
REACT:R-HSA-5685603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAP and EAT2 binds SLAMF6 (Homo sapiens)
REACT:R-HSA-139917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAX protein (Homo sapiens)
RHEA:66885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:36658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine <=> descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine
RHEA:55267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine
REACT:R-DRE-5334794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABPs bind LCFAs (Danio rerio)
RHEA:49435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + lithocholoyl-CoA <=> choloyl-CoA + lithocholate
RHEA:68980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tauroursodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH
REACT:R-MMU-1250264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP binds reduced thioredoxin (Mus musculus)
RHEA:21004	skos:altLabel	"2-dehydropantoyl-lactone reductase (flavin)"
RHEA:21004	skos:prefLabel	"(R)-pantolactone dehydrogenase (flavin)"
RHEA:21004	skos:altLabel	"(R)-pantoyllactone dehydrogenase (flavin)"
RHEA:21004	skos:altLabel	"2-dehydropantolactone reductase (flavin)"
RHEA:21004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantolactone + A = 2-dehydropantolactone + AH2
RHEA:21004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-pantolactone dehydrogenase (flavin)"
RHEA:46182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + AMP + diphosphate => 2-methylbutanoate + ATP + CoA
REACT:R-MMU-1358792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates activated ERBB3 (Mus musculus)
REACT:R-XTR-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Xenopus tropicalis)
RHEA:68824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (Z)-beta-ocimene + diphosphate
RHEA:21838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-arabinonate + H2O => D-arabinonate
RHEA:31083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-muramoyl-L-alanine = L-alanine + N-acetyl-D-muramate
REACT:R-XTR-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Xenopus tropicalis)
REACT:R-HSA-749456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
RHEA:59233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + hydropyrenol
REACT:R-HSA-5210921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pagA binds ANTXR1 (Homo sapiens)
REACT:R-XTR-1299359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TALK (Xenopus tropicalis)
RHEA:62619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose <=> a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)
RHEA:46225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H2O => (E)-ferulate + CoA + H(+)
RHEA:42356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA
RHEA:39177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-eicosenoyl-CoA + H2O => (3R)-hydroxyeicosanoyl-CoA
RHEA:10795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2
REACT:R-RNO-5654730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Rattus norvegicus)
RHEA:59775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + O2 <=> D-sorbopyranose + H2O2
REACT:R-GGA-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Gallus gallus)
REACT:R-GGA-5624956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds INPP5E (Gallus gallus)
REACT:R-RNO-2197697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Rattus norvegicus)
GO:0033800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoflavone 7-O-methyltransferase activity
GO:0033800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity
RHEA:21163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ADP + oxaloacetate + phosphate <=> ATP + citrate + CoA
RHEA:68484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxydodecanoate + H(+) = CO2 + H2O + undecanal
REACT:R-CFA-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Canis familiaris)
REACT:R-BTA-170087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Bos taurus)
RHEA:11008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate
REACT:R-XTR-390250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Xenopus tropicalis)
REACT:R-HSA-9694277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp8 generates RNA primers (Homo sapiens)
REACT:R-DRE-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)
RHEA:65111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene C + L-prolyl-[peptidyl-carrier protein] <=> aculene A + holo-[peptidyl-carrier protein]
GO:0140640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalytic activity, acting on a nucleic acid
REACT:R-DME-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Drosophila melanogaster)
REACT:R-GGA-8875591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK7 activates RAC1 (Gallus gallus)
RHEA:69373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexanoate + O2 => 2-oxohexanoate + H2O2
REACT:R-MMU-5694109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer hydrolyses TAG to DAG and FA (Mus musculus)
REACT:R-MMU-9705794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 binds SRD5A2 inhibitors (Mus musculus)
REACT:R-MMU-450333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
REACT:R-BTA-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Bos taurus)
REACT:R-BTA-1170539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor is internalized (Bos taurus)
REACT:R-CEL-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Caenorhabditis elegans)
GO:0004301	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	epoxide hydratase activity
GO:0004301	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	soluble epoxide hydrolase activity
GO:0004301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxide hydrolase activity
GO:0004301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytosolic epoxide hydrolase activity
GO:0004301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-stilbene oxide hydrolase activity
GO:0004301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sEH
GO:0004301	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	epoxide hydrase activity
GO:0004301	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aryl epoxide hydrase activity
GO:0004301	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arene-oxide hydratase activity
REACT:R-MMU-9013111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GAPs stimulate RHOC GTPase activity (Mus musculus)
RHEA:30695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal + H2O + NAD(+) = beta-alanine + 2 H(+) + NADH
RHEA:67534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O
RHEA:50937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate => acetoacetyl-CoA + L-glutamate
RHEA:65066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + pestalodiol => dimethylallyl diphosphate + siccayne
REACT:R-HSA-376117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JLP interacts with CDO complex (Homo sapiens)
RHEA:36885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:21504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetoin--ribose-5-phosphate transaldolase"
RHEA:21504	skos:altLabel	"1-deoxy-D-altro-heptulose-7-phosphate synthetase"
RHEA:21504	skos:prefLabel	"acetoin--ribose-5-phosphate transaldolase"
RHEA:21504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin + aldehydo-D-ribose 5-phosphate = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde
REACT:R-CFA-8964333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Canis familiaris)
RHEA:56562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP => [1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose
GO:0000977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II regulatory region DNA binding
GO:0015094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
GO:0015094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lead ion transmembrane transporter activity
RHEA:46487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
REACT:R-MMU-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Mus musculus)
REACT:R-GGA-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)
RHEA:13004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O <=> 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate
REACT:R-PFA-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Plasmodium falciparum)
REACT:R-CFA-2395223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyridinoline cross-links (Canis familiaris)
REACT:R-CFA-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Canis familiaris)
REACT:R-DME-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Drosophila melanogaster)
RHEA:61523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dopamine <=> 3-tyramine + A + H2O
REACT:R-GGA-1358791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of USP8 by P-AKT (Gallus gallus)
REACT:R-HSA-9672172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to mutant PDGFR receptor (Homo sapiens)
REACT:R-DME-1433415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 (Drosophila melanogaster)
REACT:R-BTA-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Bos taurus)
REACT:R-RNO-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Rattus norvegicus)
REACT:R-SSC-6786124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3,STAT6 bind p-Y-IL4R (Sus scrofa)
REACT:R-CEL-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Caenorhabditis elegans)
RHEA:69087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + H2O + NAD(+) <=> acrylate + 2 H(+) + NADH
REACT:R-DRE-8851298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR143 binds L-Dopa (Danio rerio)
REACT:R-CFA-5229132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 binds APP (Canis familiaris)
RHEA:23705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + 4 H2O => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate
REACT:R-CFA-372705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
RHEA:36611	skos:prefLabel	"(5R)-carbapenem-3-carboxylate synthase"
RHEA:36611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(5R)-carbapenem-3-carboxylate synthase"
RHEA:36611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 = (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate
RHEA:31046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonate semialdehyde + H2O + NAD(+) <=> 2 H(+) + methylmalonate + NADH
RHEA:51523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + S-adenosyl-L-methionine <=> (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine
RHEA:54935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] <=> (2E,9Z)-hexadecadienoyl-[ACP] + H2O
REACT:R-HSA-9612996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates (Homo sapiens)
RHEA:32131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2
RHEA:10286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-beta-leucine => L-leucine
RHEA:17475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate + formate + H(+) => GTP + H2O
REACT:R-GGA-9627107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP7 (Gallus gallus)
REACT:R-HSA-8963913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D translocates from cytosol to nucleoplasm (Homo sapiens)
REACT:R-GGA-389381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gads binds CD28 (Gallus gallus)
RHEA:27900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + phosphate => 3'-AMP + H2O
REACT:R-DRE-9707977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Danio rerio)
RHEA:10968	skos:prefLabel	"acid--CoA ligase (GDP-forming)"
RHEA:10968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acid--CoA ligase (GDP-forming)"
RHEA:10968	skos:altLabel	"acyl-CoA synthetase (GDP-forming)"
RHEA:10968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + CoA + GTP = an acyl-CoA + GDP + phosphate
REACT:R-XTR-6814153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADO oxidises 2AET to HTAU (Xenopus tropicalis)
REACT:R-CEL-6809263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Caenorhabditis elegans)
RHEA:51271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norbelladine + S-adenosyl-L-methionine <=> 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine
RHEA:35075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	doxorubicin(in) + H(+)(out) = doxorubicin(out) + H(+)(in)
REACT:R-HSA-5357860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Homo sapiens)
REACT:R-DRE-390224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Danio rerio)
REACT:R-SPO-9635739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 dephosphorylates p-T,Y-MAPKs (Schizosaccharomyces pombe)
REACT:R-SPO-964970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXL (Schizosaccharomyces pombe)
GO:0099104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium channel activator activity
REACT:R-HSA-741386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 induces K63-linked ubiquitination of NEMO (Homo sapiens)
RHEA:61273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminopentanoate + O2 => 2-oxopentanoate + H2O2 + NH4(+)
REACT:R-SSC-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Sus scrofa)
REACT:R-CFA-5696230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO1 dimer reduces methylarsonate to methylarsonite (Canis familiaris)
REACT:R-XTR-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Xenopus tropicalis)
RHEA:21228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltose = beta-maltose
REACT:R-HSA-1254386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 forms a complex with estrogen receptor ESR1 (Homo sapiens)
RHEA:68021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl phosphate + H2O => (2E)-geraniol + phosphate
REACT:R-SSC-1861621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIA with IgG-coated Ag (Sus scrofa)
RHEA:56051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein + UDP-alpha-D-glucose <=> daidzein 7-O-beta-D-glucoside + UDP
REACT:R-RNO-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Rattus norvegicus)
REACT:R-XTR-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Xenopus tropicalis)
RHEA:52895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nitrosobenzene <=> H(+) + NADPH + nitrobenzene
REACT:R-MMU-8940959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurolysin degrades neurotensin (Mus musculus)
REACT:R-SCE-8870469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT geranylgeranylates RAB proteins (Saccharomyces cerevisiae)
RHEA:69065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 => H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline
RHEA:35826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + NAD(+) <=> 7,8-dihydromethanopterin + H(+) + NADH
RHEA:40853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-pentadecenoyl-CoA + FADH2 => FAD + H(+) + pentadecanoyl-CoA
REACT:R-DME-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Drosophila melanogaster)
RHEA:29377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + phosphate => AMP + H2O
RHEA:29213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + inosine(out) => H(+)(out) + inosine(in)
REACT:R-MMU-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Mus musculus)
RHEA:27539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde
REACT:R-MMU-211193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization  of DFF40 (Mus musculus)
REACT:R-SSC-6805740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 methylates TP53 (Sus scrofa)
RHEA:17123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-homocitrulline + phosphate => carbamoyl phosphate + L-lysine
RHEA:58937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH => all-trans-lycopaoctaene + 2 diphosphate + NAD(+)
REACT:R-XTR-209536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkB is ubiquitinated and degraded (Xenopus tropicalis)
GO:0035064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylated histone binding
RHEA:39639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA = (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O
RHEA:45769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-L-alaninol + H2O => L-alaninol + L-glutamate
REACT:R-SSC-8944218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VIII (Sus scrofa)
RHEA:22060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:22060	skos:prefLabel	"biotin synthase"
RHEA:22060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biotin synthase"
RHEA:64304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenylpropylamine + pyruvate = 1-phenylpropan-1-one + L-alanine
REACT:R-CFA-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Canis familiaris)
REACT:R-HSA-9036077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HYAL1 does not hydrolyse (HA)50 (Homo sapiens)
RHEA:51706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthohumol
GO:0018739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-CoA thiolesterase activity
GO:0018739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-CoA thioesterase activity
GO:0018739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoyl-CoA hydrolase activity
REACT:R-DRE-8987096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Danio rerio)
REACT:R-SSC-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Sus scrofa)
RHEA:38252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + octadecanoyl-CoA => CoA + hexadecanyl octadecanoate
RHEA:40053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(1-carboxyvinyl)-oxy]benzoate + H2O => chorismate
RHEA:38907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + S-adenosyl-L-methionine = (R)-laudanine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-2168982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XVI degradation by MMP9 (Homo sapiens)
RHEA:42490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-N-debenzoyl-2'-deoxytaxol + CoA => (3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III
RHEA:40048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trioctanoylglycerol + H2O => 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate
REACT:R-DRE-1671687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR activation (Danio rerio)
REACT:R-HSA-9668831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CST complex formation (Homo sapiens)
RHEA:61412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(D-erythrulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine
RHEA:38311	skos:prefLabel	"carminomycin 4-O-methyltransferase"
RHEA:38311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carminomycin 4-O-methyltransferase"
RHEA:38311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carminomycin + S-adenosyl-L-methionine = daunorubicin + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-204958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)
REACT:R-GGA-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Gallus gallus)
RHEA:22121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + GTP + succinate => GDP + phosphate + succinyl-CoA
RHEA:21181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol => D-glucose + indole-3-acetyl-1D-myo-inositol
RHEA:56632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neryl diphosphate = 1,8-cineole + diphosphate
REACT:R-CFA-1067651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Canis familiaris)
REACT:R-RNO-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Rattus norvegicus)
GO:0052816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain hydrolase activity
GO:0052816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain acyl-CoA hydrolase activity
GO:0052816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-acyl-CoA hydrolase activity
GO:0052816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain acyl coenzyme A hydrolase activity
GO:0052816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain acyl-thioester hydrolase activity
REACT:R-SPO-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Schizosaccharomyces pombe)
RHEA:56288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]
RHEA:56288	skos:prefLabel	"albendazole monooxygenase (hydroxylating)"
RHEA:56288	skos:altLabel	"CYP2J2"
RHEA:56288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"albendazole monooxygenase (hydroxylating)"
REACT:R-DRE-2160915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor-mediated uptake of HA (Danio rerio)
RHEA:20814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + oxaloacetate => (3S)-citryl-CoA
REACT:R-HSA-8858346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMHR2 binds AMH (Homo sapiens)
RHEA:32158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine <=> adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine
RHEA:67240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-adenosyl-L-methionine hydrolase (adenosine-forming)"
RHEA:67240	skos:altLabel	"SAM hydroxide adenosyltransferase"
RHEA:67240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-adenosyl-L-methionine + H2O = adenosine + H(+) + L-methionine
RHEA:67240	skos:prefLabel	"S-adenosyl-L-methionine hydrolase (adenosine-forming)"
RHEA:54233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycerol + CDP-choline => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:68278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-butanoyl-L-seryl-[protein] => butanoyl-CoA + L-seryl-[protein]
RHEA:52328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + O2 + reduced [flavodoxin] = H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]
GO:0036175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
GO:0036175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
GO:0036175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor
REACT:R-HSA-350158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGMN degrades GC (Homo sapiens)
REACT:R-HSA-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Homo sapiens)
REACT:R-GGA-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Gallus gallus)
RHEA:13588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoate <=> ADP + butanoyl phosphate
REACT:R-MMU-171122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL + LDLR => LDL:LDLR complex (Mus musculus)
REACT:R-DME-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Drosophila melanogaster)
REACT:R-HSA-1433451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds to p-KIT (Homo sapiens)
REACT:R-DRE-4551655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Danio rerio)
RHEA:55518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:33696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C20 sphinganine + NADP(+) => 3-oxoeicosasphinganine + H(+) + NADPH
REACT:R-MMU-163820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Mus musculus)
REACT:R-CEL-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Caenorhabditis elegans)
REACT:R-RNO-9646685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggresome dissociates from dynein and microtubule (Rattus norvegicus)
REACT:R-HSA-8936989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter (Homo sapiens)
RHEA:28575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + sulfate(in) => H(+)(out) + sulfate(out)
RHEA:14505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + thiosulfate = glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite
RHEA:14505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiosulfate--thiol sulfurtransferase"
RHEA:14505	skos:altLabel	"sulfane reductase"
RHEA:14505	skos:altLabel	"glutathione-dependent thiosulfate reductase"
RHEA:14505	skos:prefLabel	"thiosulfate--thiol sulfurtransferase"
REACT:R-HSA-6807242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D translocates from ER membrane to extracellular region (Homo sapiens)
RHEA:41222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)
RHEA:64009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine
GO:0046025	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	precorrin-6Y methylase activity
GO:0046025	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	precorrin-6 methyltransferase activity
GO:0046025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6Y C5,15-methyltransferase (decarboxylating) activity
GO:0046025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)
RHEA:72226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) <=> 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)
REACT:R-DRE-351877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 2 (Danio rerio)
RHEA:16417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) = H(+) + L-glutamate + NADH
RHEA:25938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-methylquinolin-2(1H)-one + AH2 => 8-methylquinoline + A + H2O
REACT:R-SSC-176646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Sus scrofa)
RHEA:51577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phloretin + UDP-alpha-D-glucose => H(+) + phlorizin + UDP
REACT:R-HSA-9761854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent ME1 gene expression (Homo sapiens)
REACT:R-HSA-70555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Homo sapiens)
REACT:R-DRE-9014296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GEFs activate RAC2 (Danio rerio)
RHEA:61513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malvidin + UDP-alpha-D-glucose => malvidin 3-O-beta-D-glucoside + UDP
RHEA:62609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + H(+) + hydrogen sulfide + ubiquinone-10 => S-sulfanylglutathione + ubiquinol-10
RHEA:71211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorate(out) + 2 Na(+)(out) = chlorate(in) + 2 Na(+)(in)
REACT:R-BTA-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Bos taurus)
REACT:R-HSA-1655834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:SCAP translocates to the Golgi (Homo sapiens)
RHEA:58355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate
GO:0008776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AckA
GO:0008776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetokinase activity
GO:0008776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate kinase activity
GO:0008776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetic kinase activity
GO:0008776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AK activity
GO:0008776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:acetate phosphotransferase activity
GO:0008776	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetate kinase (phosphorylating) activity
EC:3.4.21.112	skos:altLabel	"mammalian subtilisin/kexin isozyme 1"
EC:3.4.21.112	skos:altLabel	"proprotein convertase SKI-1/S1PPS1"
EC:3.4.21.112	skos:altLabel	"sterol regulatory element-binding protein site 1 protease"
EC:3.4.21.112	skos:altLabel	"SREBP-2 proteinase"
EC:3.4.21.112	skos:altLabel	"SREBP-1 proteinase"
EC:3.4.21.112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"site-1 protease"
EC:3.4.21.112	skos:altLabel	"S1P protease"
EC:3.4.21.112	skos:altLabel	"SREBP proteinase"
EC:3.4.21.112	skos:altLabel	"subtilase SKI-1"
EC:3.4.21.112	skos:altLabel	"SKI-1"
EC:3.4.21.112	skos:altLabel	"sterol-regulated luminal protease"
EC:3.4.21.112	skos:prefLabel	"site-1 protease"
EC:3.4.21.112	skos:altLabel	"S1P endopeptidase"
EC:3.4.21.112	skos:altLabel	"subtilisin/kexin isozyme 1"
EC:3.4.21.112	skos:altLabel	"SREBP S1 protease"
EC:3.4.21.112	skos:altLabel	"membrane-bound transcription factor site-1 protease"
EC:3.4.21.112	skos:altLabel	"sterol regulatory element-binding protein proteinase"
EC:3.4.21.112	skos:altLabel	"site-1 peptidase"
EC:3.4.21.112	skos:altLabel	"proprotein convertase SKI-1"
EC:3.4.21.112	skos:altLabel	"subtilase SKI-1/S1P"
RHEA:52533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + GTP => AMP + GDP + H(+)
REACT:R-RNO-981809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Rattus norvegicus)
RHEA:13769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NAD(+) = dihydroxyacetone + H(+) + NADH
RHEA:13769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol dehydrogenase"
RHEA:13769	skos:altLabel	"NAD-linked glycerol dehydrogenase"
RHEA:13769	skos:prefLabel	"glycerol dehydrogenase"
REACT:R-MMU-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Mus musculus)
RHEA:29270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine(in) + Na(+)(in) <=> L-valine(out) + Na(+)(out)
REACT:R-MMU-912757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S585-IL3RB binds 14-3-3 proteins (Mus musculus)
RHEA:29845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + phosphate + propanoyl-CoA => ATP + CoA + propanoate
RHEA:55760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lyso-ornithine lipid O-acyltransferase"
RHEA:55760	skos:prefLabel	"lyso-ornithine lipid O-acyltransferase"
RHEA:55760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + a lyso-ornithine lipid = an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]
RHEA:52872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-XTR-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Xenopus tropicalis)
RHEA:23016	skos:altLabel	"NADPH-dihydromyricetin reductase"
RHEA:23016	skos:prefLabel	"dihydroflavanol 4-reductase"
RHEA:23016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroflavanol 4-reductase"
RHEA:23016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) = (2R,3R)-dihydrokaempferol + H(+) + NADPH
RHEA:23016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + H(+) + NADPH
RHEA:23016	skos:altLabel	"dihydroflavonol 4-reductase"
RHEA:23016	skos:altLabel	"dihydrokaempferol 4-reductase"
REACT:R-MMU-982765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone forms dimers and oligomers (Mus musculus)
RHEA:50623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-XTR-1295634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is serine phosphorylated in response to MAPK activation (Xenopus tropicalis)
RHEA:61148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP
REACT:R-HSA-3215391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 is tyrosine phosphorylated by JAK2 V617F (Homo sapiens)
REACT:R-DDI-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Dictyostelium discoideum)
REACT:R-DME-390087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WTS binds to SAV (Drosophila melanogaster)
GO:0051787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Homo sapiens)
GO:0051787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded protein binding
REACT:R-HSA-9606151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
REACT:R-BTA-2076220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
REACT:R-RNO-8871376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds PI3P (Rattus norvegicus)
REACT:R-PFA-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
RHEA:25284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + squalene
REACT:R-XTR-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Xenopus tropicalis)
EC:3.4.24.51	skos:altLabel	"Ophiophagus metalloendopeptidase"
EC:3.4.24.51	skos:prefLabel	"ophiolysin"
EC:3.4.24.51	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ophiolysin"
REACT:R-HSA-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Homo sapiens)
REACT:R-RNO-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)
RHEA:55559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxyeicosatetraenoate <=> an oxoeicosatetraenoate + H2O
RHEA:63708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:65010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-AMP + diphosphate => ATP + decanoate + H(+)
RHEA:49014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C epoxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2
RHEA:25918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-6-ol
REACT:R-RNO-9026780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)
REACT:R-XTR-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Xenopus tropicalis)
REACT:R-HSA-4084990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear CMP-Neu5Ac translocates to cytosol (Homo sapiens)
REACT:R-SSC-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Sus scrofa)
REACT:R-GGA-445069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-EGFR trans-heterodimerization (Gallus gallus)
RHEA:15768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + GTP <=> adenosylcob(III)inamide phosphate + GDP + H(+)
RHEA:27606	skos:prefLabel	"L-serine-phosphatidylethanolamine phosphatidyltransferase"
RHEA:27606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-serine-phosphatidylethanolamine phosphatidyltransferase"
RHEA:27606	skos:altLabel	"phosphatidylserine synthase 2"
RHEA:27606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-CFA-5633460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds TP53 (Canis familiaris)
RHEA:19478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)
REACT:R-HSA-5649711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 incises DNA strand 5' to the AP site (Homo sapiens)
REACT:R-MMU-8866405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)
REACT:R-BTA-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Bos taurus)
RHEA:16374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)
GO:0047331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPi-glycerol phosphotransferase activity
GO:0047331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate--glycerol phosphotransferase activity
GO:0047331	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphate:glycerol 1-phosphotransferase activity
GO:0047331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate-glycerol phosphotransferase activity
REACT:R-MMU-377186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Mus musculus)
RHEA:66824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate
RHEA:36631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)
REACT:R-SSC-2395965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Sus scrofa)
REACT:R-DDI-1605736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Dictyostelium discoideum)
REACT:R-DRE-2130641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TGN-lysosome vesicle to lysosome (Danio rerio)
REACT:R-DRE-70920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Danio rerio)
RHEA:46200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:3.6.1.65	skos:altLabel	"(d)CTP diphosphohydrolase"
EC:3.6.1.65	skos:altLabel	"(d)CTP pyrophosphohydrolase"
EC:3.6.1.65	skos:prefLabel	"(d)CTP diphosphatase"
EC:3.6.1.65	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(d)CTP diphosphatase"
REACT:R-BTA-5694410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMED2:TMED10 tetramer binds GPI anchored proteins (Bos taurus)
RHEA:22769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenyl-3-ketovalidamine => 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one
REACT:R-HSA-5210944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)
REACT:R-DME-8938867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND3,(CCND1,CCND2) binds RUNX1 (Drosophila melanogaster)
RHEA:50248	skos:altLabel	"diphosphate adenylyltransferase"
RHEA:50248	skos:prefLabel	"ADP-D-ribose pyrophosphorylase"
RHEA:50248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-D-ribose pyrophosphorylase"
RHEA:50248	skos:altLabel	"NUDIX5"
RHEA:50248	skos:altLabel	"diphosphate--ADP-D-ribose adenylyltransferase"
RHEA:50248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + diphosphate
RHEA:26211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + glycine => L-allo-threonine
RHEA:41941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate
RHEA:12259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arogenate + NAD(+) <=> CO2 + L-tyrosine + NADH
REACT:R-SPO-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Schizosaccharomyces pombe)
REACT:R-HSA-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Homo sapiens)
REACT:R-XTR-6784791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Xenopus tropicalis)
RHEA:39287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[trimethylamine--corrinoid protein] Co-methyltransferase"
RHEA:39287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine = dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]
RHEA:39287	skos:altLabel	"trimethylamine methyltransferase"
RHEA:39287	skos:prefLabel	"[trimethylamine--corrinoid protein] Co-methyltransferase"
RHEA:34133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabinerolate + diphosphate => neryl diphosphate + olivetolate
REACT:R-BTA-5218830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates PTK2-beta (Bos taurus)
REACT:R-XTR-202165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ITAM motifs in CD3 complexes (Xenopus tropicalis)
RHEA:52150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic (Z)-desulfo-glucosinolate + UDP => a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose
REACT:R-HSA-5340385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAVCR2 binds LGALS9 (Homo sapiens)
EC:3.4.24.80	skos:prefLabel	"membrane-type matrix metalloproteinase-1"
EC:3.4.24.80	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"membrane-type matrix metalloproteinase-1"
EC:3.4.24.80	skos:altLabel	"matrix metalloproteinase 14"
RHEA:56226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-XTR-4655431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOyation of DNMT1 with SUMO1 (Xenopus tropicalis)
RHEA:51568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:21125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine
RHEA:56757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
GO:0052798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-galactoside alpha-2,3-sialyltransferase activity
GO:0052798	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	trans-sialidase activity
REACT:R-DME-209109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further phosphorylation of ARM by SGG (Drosophila melanogaster)
RHEA:21897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate
REACT:R-RNO-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Rattus norvegicus)
REACT:R-XTR-77586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Xenopus tropicalis)
REACT:R-CFA-2730837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-10Y-NTAL (Canis familiaris)
REACT:R-DRE-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Danio rerio)
REACT:R-DRE-975903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Danio rerio)
REACT:R-BTA-170843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 phosphorylates TGFBR1 (Bos taurus)
REACT:R-DME-374899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of noradrenaline  at the synapse (Drosophila melanogaster)
REACT:R-CFA-205321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of KIT and sSCF (Canis familiaris)
REACT:R-DRE-177942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EGF ligand (Danio rerio)
REACT:R-RNO-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Rattus norvegicus)
REACT:R-SSC-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Sus scrofa)
REACT:R-SSC-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Sus scrofa)
REACT:R-RNO-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Rattus norvegicus)
GO:0047863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity
GO:0047863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate
GO:0047863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallylcistransferase activity
GO:0047863	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neryl-diphosphate synthase activity
GO:0047863	skos:prefLabel	"dimethylallylcistransferase"
GO:0047863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylallylcistransferase"
GO:0047863	skos:altLabel	"neryl-diphosphate synthase"
REACT:R-BTA-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Bos taurus)
REACT:R-CFA-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Canis familiaris)
RHEA:49450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose => beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O
RHEA:41645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate
RHEA:10362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-hydroxyphenyl)propanoate + H(+) => 3,4-dihydrocoumarin + H2O
REACT:R-SCE-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Saccharomyces cerevisiae)
RHEA:19660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH
RHEA:39453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA
RHEA:25634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laricitrin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + syringetin
REACT:R-SSC-9021660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds membrane-associated estrogen receptors (Sus scrofa)
REACT:R-DDI-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Dictyostelium discoideum)
RHEA:62505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] => 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate
REACT:R-CFA-1483089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is converted to PS by PTDSS2 (Canis familiaris)
REACT:R-HSA-2872498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Homo sapiens)
RHEA:72698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) <=> UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)
RHEA:55169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-RNO-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Rattus norvegicus)
REACT:R-DME-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)
REACT:R-CEL-5624486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylates RAF1 on Y340,Y341 (Caenorhabditis elegans)
REACT:R-MMU-983218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B:RAD51C binds single-stranded DNA (Mus musculus)
REACT:R-CFA-8855508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)
REACT:R-CEL-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Caenorhabditis elegans)
REACT:R-HSA-1655843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Fatty Acid Synthase (FASN) (Homo sapiens)
REACT:R-MMU-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Mus musculus)
REACT:R-DME-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)
GO:0015167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabitol transmembrane transporter activity
GO:0015167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinitol transporter activity
RHEA:65970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O
RHEA:42415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + ATP + H(+) <=> ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate
REACT:R-MMU-5621571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD209 binds ICAM2 (Mus musculus)
REACT:R-DME-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Drosophila melanogaster)
RHEA:43536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate
RHEA:43536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(5-formylfuran-3-yl)methyl phosphate synthase"
RHEA:43536	skos:altLabel	"4-HFC-P synthase"
RHEA:43536	skos:altLabel	"2-furaldehyde phosphate synthase"
RHEA:43536	skos:prefLabel	"(5-formylfuran-3-yl)methyl phosphate synthase"
RHEA:24513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + H2O
RHEA:15141	skos:prefLabel	"4-methylphenol dehydrogenase (hydroxylating)"
RHEA:15141	skos:altLabel	"p-cresol methylhydroxylase"
RHEA:15141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-methylphenol dehydrogenase (hydroxylating)"
RHEA:15141	skos:altLabel	"4-cresol dehydrogenase (hydroxylating)"
RHEA:15141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol + H2O + 4 oxidized [azurin] = 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]
RHEA:15141	skos:altLabel	"p-cresol-(acceptor) oxidoreductase (hydroxylating)"
RHEA:33238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 <=> 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)
REACT:R-CFA-170070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)
RHEA:64618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferyl acetate + CoA => (E)-coniferol + acetyl-CoA
GO:1901338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catecholamine binding
RHEA:25267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + H2O2 + NH4(+) => 2-phenylethylamine + H2O + O2
REACT:R-HSA-1912353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of Pre-NOTCH by POGLUT1 (Homo sapiens)
REACT:R-DME-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Drosophila melanogaster)
REACT:R-DRE-873918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of JAK1 (Danio rerio)
RHEA:18326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-amorpha-4,11-diene + diphosphate
RHEA:34275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)"
RHEA:34275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine
RHEA:34275	skos:prefLabel	"2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)"
REACT:R-SSC-446868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Interleukin 1 receptor complex binds Tollip (Sus scrofa)
RHEA:25922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-7-ol
REACT:R-MMU-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Mus musculus)
RHEA:51631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) + UTP <=> CO2 + dUTP + H2O
RHEA:11338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine
REACT:R-MMU-2022412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)
GO:0004933	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class D GPCR activity
GO:0004933	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class D G protein coupled receptor activity
GO:0004933	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class D G-protein-coupled receptor activity
GO:0004933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mating-type a-factor pheromone receptor activity
GO:0004933	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	class D G-protein coupled receptor activity
RHEA:41816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GD2 (d18:1(4E)) + H(+) + UDP
GO:0015636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	short-chain fatty acid transmembrane transporter activity
GO:0015636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short-chain fatty acid transporter activity
GO:0015636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short-chain fatty acid uptake transporter activity
GO:0008460	skos:prefLabel	"dTDP-glucose 4,6-dehydratase"
GO:0008460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDP-glucose oxidoreductase activity
GO:0008460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O
GO:0008460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-glucose 4,6-hydro-lyase activity
GO:0008460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)
GO:0008460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-glucose 4,6-dehydratase activity
GO:0008460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-glucose 4,6-dehydratase"
GO:0008460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphosphoglucose oxidoreductase activity
GO:0008460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDPglucose 4,6-dehydratase activity
GO:0008460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDPglucose 4,6-hydro-lyase activity
REACT:R-RNO-5607023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IXa associates with cell membrane (Rattus norvegicus)
RHEA:64903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UTP <=> H(+) + phosphate + UDP
RHEA:15378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4,5-dihydroxypentane-2,3-dione + ATP => (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)
GO:0047520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	11-cis-retinyl-palmitate acylhydrolase activity
GO:0047520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RPH
GO:0047520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinyl-palmitate hydrolase activity
GO:0047520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	11-cis-retinol palmitate esterase activity
RHEA:63690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP
RHEA:30744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-riboside + H2O => D-ribose + H(+) + nicotinamide
REACT:R-HSA-374337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apelin receptor binds to apelin (Homo sapiens)
RHEA:24393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-L-dihydrostreptose + streptidine 6-phosphate => dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate
REACT:R-RNO-9750942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP14 deubiquitinates NLRC5 (Rattus norvegicus)
REACT:R-MMU-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Mus musculus)
RHEA:52421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-phospho-L-serine + thiosulfate => phosphate + S-sulfo-L-cysteine
RHEA:24310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-5651789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to POLB ligates SSB (Mus musculus)
REACT:R-BTA-69600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic degradation of ubiquitinated-Cdc25A (Bos taurus)
REACT:R-RNO-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Rattus norvegicus)
RHEA:35132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-glutamate(out) => H(+)(in) + L-alanyl-L-glutamate(in)
RHEA:66676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide = 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate
REACT:R-CFA-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
REACT:R-HSA-3780997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG2:GYS2 (Homo sapiens)
GO:0015453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreduction-driven active transmembrane transporter activity
GO:0015453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreduction-driven transporter
RHEA:64901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UTP => H(+) + phosphate + UDP
REACT:R-RNO-201515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK recruits PI3K (Rattus norvegicus)
RHEA:60114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-3-(indol-3-yl)acryloyl-CoA + H2O => (R)-3-(indol-3-yl)lactoyl-CoA
REACT:R-DRE-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Danio rerio)
REACT:R-XTR-139909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BMF to mitochondria (Xenopus tropicalis)
GO:0033958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA(hypoxanthine) glycohydrolase activity
GO:0033958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic acid glycosylase activity
GO:0033958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-deoxyinosine glycosylase activity
GO:0033958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hypoxanthine-DNA glycosylase activity
GO:0033958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-deoxyinosine glycosidase activity
GO:0033958	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-deoxyinosine deoxyribohydrolase activity
RHEA:11404	skos:altLabel	"UDP-galacturonate 4-epimerase"
RHEA:11404	skos:prefLabel	"UDP-glucuronate 4-epimerase"
RHEA:11404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-glucuronate 4-epimerase"
RHEA:11404	skos:altLabel	"UDP glucuronic epimerase"
RHEA:11404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate
RHEA:11404	skos:altLabel	"uridine diphosphoglucuronate epimerase"
RHEA:30780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + FAD + H(+) => 2-dehydro-D-gluconate + FADH2
RHEA:47693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + neomycin C + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B
REACT:R-SSC-418176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB2 binds MAPKs, SRC-1 (Sus scrofa)
REACT:R-BTA-174551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of alternative pathway C5 convertase (Bos taurus)
REACT:R-RNO-1251997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ERBB4m80 by gamma-scretase complex (Rattus norvegicus)
RHEA:16811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + succinate => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate
RHEA:14071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-fructose + H(+) + NADPH => D-fructose + NADP(+)
REACT:R-BTA-2453876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTR:RBP:atROL binds to STRA6 receptor (Bos taurus)
REACT:R-RNO-5669023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TWEAK binds FN14 (Rattus norvegicus)
REACT:R-HSA-9773803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKBKB phosphorylates NF-kappa-B inhibitor  (Homo sapiens)
RHEA:55346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol
REACT:R-DRE-2730863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 by PKC-theta (Danio rerio)
REACT:R-BTA-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
REACT:R-CFA-6809325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)
REACT:R-MMU-5358336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB forms mixed disulphides with Hh precursors (Mus musculus)
REACT:R-GGA-451439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR7 or 21 recruits MyD88 (Gallus gallus)
RHEA:43291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate
RHEA:69469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose => L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose
RHEA:58471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate
RHEA:55641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)
RHEA:14972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-aconitate <=> (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine
REACT:R-CEL-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Caenorhabditis elegans)
RHEA:70024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(in) + Na(+)(in) => 4-hydroxy-L-proline(out) + Na(+)(out)
REACT:R-HSA-5618110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Homo sapiens)
RHEA:35128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-D-glutamate(out) => L-alanyl-D-glutamate(in)
REACT:R-BTA-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Bos taurus)
REACT:R-HSA-5210959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)
RHEA:49721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NAD(+) + violacein
RHEA:49447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetyl-CoA + H2O <=> (2-aminobenzoyl)acetate + CoA + H(+)
GO:0047762	skos:prefLabel	"caffeate 3,4-dioxygenase"
GO:0047762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caffeate 3,4-dioxygenase"
GO:0047762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing)
GO:0047762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeate 3,4-dioxygenase activity
GO:0047762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)
EC:1.6.99.-	skos:prefLabel	"With other acceptors"
EC:1.6.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
RHEA:10460	skos:prefLabel	"prostaglandin-A1 Delta-isomerase"
RHEA:10460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin A1 = prostaglandin C1
RHEA:10460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prostaglandin-A1 Delta-isomerase"
RHEA:10460	skos:altLabel	"prostaglandin A isomerase"
RHEA:61510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peonidin 3-O-beta-D-glucoside + UDP => peonidin + UDP-alpha-D-glucose
REACT:R-HSA-5632766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates SCO2 gene transcription (Homo sapiens)
REACT:R-DRE-5602295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F22 20-hydroxylates TrXA3 (Danio rerio)
REACT:R-DDI-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)
RHEA:62643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycoredoxin]-L-dithiol + a hydroperoxide <=> [mycoredoxin]-L-disulfide + an alcohol + H2O
RHEA:52060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)
REACT:R-SPO-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Schizosaccharomyces pombe)
REACT:R-DME-446391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the PINCH-ILK-parvin complex (Drosophila melanogaster)
REACT:R-HSA-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Homo sapiens)
REACT:R-CFA-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Canis familiaris)
REACT:R-MMU-446862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)
REACT:R-RNO-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Rattus norvegicus)
RHEA:18013	skos:prefLabel	"theanine hydrolase"
RHEA:18013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-ethyl-L-glutamine = ethylamine + L-glutamate
RHEA:18013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"theanine hydrolase"
REACT:R-RNO-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)
RHEA:42243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DRE-443774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homodimerization of Neurofascin (Danio rerio)
RHEA:17596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-glutamine <=> 2-oxoglutaramate + L-phenylalanine
RHEA:49201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate
GO:0102517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleate 12-hydroxylase activity
RHEA:42806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromethanopterin + AH2 => 5,6,7,8-tetrahydromethanopterin + A
RHEA:16843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + precorrin-3A + S-adenosyl-L-homocysteine => precorrin-2 + S-adenosyl-L-methionine
REACT:R-MMU-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Mus musculus)
REACT:R-HSA-9604499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 (Homo sapiens)
REACT:R-DME-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Drosophila melanogaster)
REACT:R-CEL-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Caenorhabditis elegans)
RHEA:52948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP
RHEA:69769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-enoate + 2 H(+) + NADH => (E)-non-2-enal + H2O + NAD(+)
REACT:R-RNO-74101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerization of 11c-retinyl to at-retinyl (Rattus norvegicus)
RHEA:56296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] = pyruvate + S-sulfanyl-L-cysteinyl-[protein]
GO:0016754	skos:prefLabel	"sinapoylglucose--malate O-sinapoyltransferase"
GO:0016754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapoylglucose-malate O-sinapoyltransferase activity
GO:0016754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sinapoylglucose--malate O-sinapoyltransferase"
GO:0016754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose = D-glucose + sinapoyl (S)-malate
GO:0016754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity
GO:0016754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapoylglucose:malate sinapoyltransferase activity
GO:0016754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-sinapoylglucose-L-malate sinapoyltransferase activity
RHEA:63182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 superoxide => NADPH + 2 O2
RHEA:69439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxopregnenolone + H(+) + NADPH <=> 7beta-hydroxypregnenolone + NADP(+)
REACT:R-BTA-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Bos taurus)
REACT:R-CEL-8964619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds ARHGEF6 (Caenorhabditis elegans)
GO:0016989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anti-sigma factor activity
GO:0016989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sigma factor antagonist activity
REACT:R-DME-2076392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcA to heparan (Drosophila melanogaster)
RHEA:22652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosylglycerol 3-phosphatase"
RHEA:22652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate
RHEA:22652	skos:prefLabel	"glucosylglycerol 3-phosphatase"
RHEA:45771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-L-alaninol + H2O <=> L-alaninol + L-glutamate
REACT:R-SCE-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Saccharomyces cerevisiae)
RHEA:18448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
RHEA:61456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chlorotetracycline + H(+) + NADPH + O2 = (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)
REACT:R-HSA-5651809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
REACT:R-DDI-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Dictyostelium discoideum)
RHEA:18774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] => Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-SSC-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Sus scrofa)
RHEA:21738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5S)-3,5-diaminohexanoate => (3S)-3,6-diaminohexanoate
REACT:R-DRE-8950522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1:p-STAT4 translocates to the nucleus (Danio rerio)
RHEA:31754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Bos taurus)
RHEA:12286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA + succinate => 3-hydroxy-3-methylglutarate + succinyl-CoA
REACT:R-BTA-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Bos taurus)
RHEA:70064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 => 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde
RHEA:15347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-tyrosyl-L-arginine => ATP + L-arginine + L-tyrosine
RHEA:16714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-succinylglutathione => glutathione + H(+) + succinate
REACT:R-CEL-8938951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PAX5 (BSAP) (Caenorhabditis elegans)
REACT:R-XTR-265427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Xenopus tropicalis)
RHEA:15475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP => flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose
RHEA:29905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-ribose(in) + H(+) + phosphate => ATP + D-ribose(out) + H2O
REACT:R-XTR-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)
RHEA:40467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)
RHEA:61849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + UDP-alpha-D-glucose => cholesteryl 3-beta-D-glucoside + H(+) + UDP
REACT:R-MMU-400037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi,Go Heterotrimeric G-protein complex dissociates (Mus musculus)
REACT:R-HSA-9609744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2B (GRIN2B) (Homo sapiens)
RHEA:20786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + L-arginine => H2O + N(omega)-(ADP-D-ribosyl)-L-arginine
REACT:R-XTR-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Xenopus tropicalis)
RHEA:66177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurochenodeoxycholate 3-sulfate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)
RHEA:21173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH
REACT:R-HSA-8944569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-25 microRNA binds PTEN mRNA (Homo sapiens)
REACT:R-MMU-3215251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53INP1 and HIPK2 bind TP53 (Mus musculus)
REACT:R-DRE-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Danio rerio)
REACT:R-DRE-9605600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Danio rerio)
REACT:R-RNO-8949668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YME1L1 proteolyzes unassembled proSMDT1 (Rattus norvegicus)
RHEA:17527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + urea-1-carboxylate => biuret + H2O
REACT:R-BTA-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Bos taurus)
RHEA:59755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]
REACT:R-HSA-9769141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 translocates to the cytosol (Homo sapiens)
RHEA:11802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) => H2O + NAD(+)
RHEA:58421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prenol => 3-methyl-2-butenal + H(+) + NADPH
RHEA:53696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
REACT:R-HSA-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Homo sapiens)
REACT:R-SSC-372480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Sus scrofa)
RHEA:53540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine
RHEA:24688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + methanofuran => H2O + N-formylmethanofuran
REACT:R-XTR-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Xenopus tropicalis)
GO:0080133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	midchain alkane hydroxylase activity
REACT:R-MMU-158795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Mus musculus)
REACT:R-MMU-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Mus musculus)
GO:0102056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyjasmonate sulfotransferase activity
REACT:R-GGA-6814096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds SCOC (Gallus gallus)
REACT:R-SSC-975147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Sus scrofa)
RHEA:19750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP
REACT:R-XTR-5229203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates histone H2A arginine-30 (H2AR29) (Xenopus tropicalis)
REACT:R-DME-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Drosophila melanogaster)
RHEA:42333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + oxidized coenzyme F420-2 => ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate
RHEA:60652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline
REACT:R-DDI-9677929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB inhibitors bind MAOB:FAD (Dictyostelium discoideum)
RHEA:10721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione
RHEA:40700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol => 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:20560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + urea <=> CO2 + 2 NH4(+)
REACT:R-DME-9603984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Drosophila melanogaster)
RHEA:33944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 L-arginine + 3 NADH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide
REACT:R-DDI-444126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Dictyostelium discoideum)
REACT:R-MMU-450292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Mus musculus)
RHEA:55139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanine + H(+) <=> D-alanyl-5'-AMP + diphosphate
RHEA:37604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-BTA-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Bos taurus)
RHEA:61761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside B + UDP-alpha-D-glucose => rebaudioside A + UDP
RHEA:60102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-beta-D-glucoside + H(+) + UDP => cyanidin + UDP-alpha-D-glucose
RHEA:39352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O
REACT:R-SSC-5654600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
REACT:R-MMU-1168642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Mus musculus)
REACT:R-SSC-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)
REACT:R-BTA-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Bos taurus)
RHEA:12118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 => A + H2
RHEA:23286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate => isopentenyl diphosphate
RHEA:59376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate
RHEA:59376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-amino-4-deoxychorismate mutase"
RHEA:59376	skos:prefLabel	"4-amino-4-deoxychorismate mutase"
REACT:R-MMU-1295621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL dissociates from ubiquitinated p-SPRY2 (Mus musculus)
REACT:R-MMU-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Mus musculus)
REACT:R-SSC-266089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Discoidal HDL binds membrane-associated free cholesterol (Sus scrofa)
GO:0102035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA:FAD oxidoreductase activity
REACT:R-CFA-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Canis familiaris)
REACT:R-RNO-2129357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin C-terminal processing (Rattus norvegicus)
REACT:R-RNO-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Rattus norvegicus)
REACT:R-CFA-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Canis familiaris)
RHEA:32588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)
REACT:R-XTR-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Xenopus tropicalis)
RHEA:53771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholate + allodeoxycholoyl-CoA <=> allocholoyl-CoA + allodeoxycholate
REACT:R-SSC-2395764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atREs binds to nascent CM (Sus scrofa)
RHEA:57002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(beta)-acetylstreptothricin F => acetyl-CoA + streptothricin F
REACT:R-CFA-8938887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML binds RUNX1 (Canis familiaris)
RHEA:37905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + tryprostatin A => 6-hydroxytryprostatin B + S-adenosyl-L-methionine
REACT:R-HSA-5693608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial resection of double-strand break ends (Homo sapiens)
REACT:R-HSA-8952807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)
RHEA:20817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxyglycyrrhetinate + NADP(+) => 3-oxoglycyrrhetinate + H(+) + NADPH
REACT:R-BTA-5610723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind SUFU (Bos taurus)
REACT:R-GGA-373741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK2 homophillic interaction (Gallus gallus)
RHEA:64158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + L-methionine => an N-(fatty acyl)-L-methionine + H2O
REACT:R-BTA-5654669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)
RHEA:19139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6beta-hydroxyestradiol-17beta + A + H2O => 17beta-estradiol + AH2 + O2
RHEA:54875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-menthone + H(+) + NADPH + O2 <=> (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)
REACT:R-MMU-8873850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD5 binds DCA, LCA (Mus musculus)
REACT:R-RNO-193713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Rattus norvegicus)
REACT:R-GGA-1977959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with EGFR (Gallus gallus)
RHEA:57630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ML-236C carboxylate => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate
REACT:R-CEL-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)
RHEA:45485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pyruvate => acetaldehyde + CO2
RHEA:16055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine
REACT:R-SCE-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Saccharomyces cerevisiae)
REACT:R-MMU-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
RHEA:72441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-AMP + diphosphate => (E)-ferulate + ATP + H(+)
RHEA:32283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 = H(+) + H2O + quinolinate
RHEA:41322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+) => 1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O
RHEA:38419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate
REACT:R-CEL-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Caenorhabditis elegans)
RHEA:39663	skos:prefLabel	"F420H2:quinone oxidoreductase"
RHEA:39663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:39663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"F420H2:quinone oxidoreductase"
REACT:R-HSA-3928627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB phosphorylates TIAM1 (Homo sapiens)
RHEA:33528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol => CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate
GO:0042393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone binding
GO:0042393	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone-specific chaperone activity
REACT:R-DRE-202510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1-TAB2 complex (Danio rerio)
REACT:R-HSA-8943041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)
REACT:R-RNO-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Rattus norvegicus)
REACT:R-RNO-9032751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Rattus norvegicus)
RHEA:56305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + rifampicin => 21-phosphorifampicin + AMP + 2 H(+) + phosphate
REACT:R-XTR-1482868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Xenopus tropicalis)
RHEA:57240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + GMP = N(2)-(1-hydroxy-2-oxoethyl)-GMP
RHEA:68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) = 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-GGA-5654634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates SHC1 (Gallus gallus)
REACT:R-RNO-9012036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)
REACT:R-SPO-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Schizosaccharomyces pombe)
REACT:R-HSA-8877396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)
REACT:R-MMU-5649701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Mus musculus)
REACT:R-BTA-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Bos taurus)
REACT:R-SSC-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)
RHEA:45828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH
REACT:R-DME-1252013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80 to the nucleus (Drosophila melanogaster)
RHEA:25817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + norspermine + O2 => 3-aminopropanal + H2O2 + norspermidine
REACT:R-RNO-5340320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTP transports GSL from plasma membrane to ER membrane (Rattus norvegicus)
REACT:R-SSC-2029459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Sus scrofa)
REACT:R-HSA-9684030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)
REACT:R-GGA-1470010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs (Gallus gallus)
REACT:R-GGA-5618093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP90 (Gallus gallus)
RHEA:71613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + malonate(in) => (S)-malate(in) + malonate(out)
GO:0033970	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ureidomalonase activity
GO:0033970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-malonylurea hydrolase activity
GO:0033970	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity
RHEA:52611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybutanoate + NADP(+) <=> 2-oxobutanoate + H(+) + NADPH
RHEA:12630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-hyoscyamine + O2 => (6S)-6-hydroxyhyoscyamine + CO2 + succinate
RHEA:47455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5Z)-tetradecadienoyl-CoA + H2O <=> (3S)-hydroxy-(5Z-tetradecenoyl)-CoA
GO:0030786	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity
GO:0030786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(RS)-norcoclaurine 6-O-methyltransferase activity
REACT:R-XTR-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Xenopus tropicalis)
RHEA:20766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + propanoyl-CoA => (S)-methylmalonyl-CoA + pyruvate
RHEA:61771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside A + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP
RHEA:46170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + pentanoyl-CoA => ATP + CoA + pentanoate
REACT:R-MMU-203973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle budding (Mus musculus)
RHEA:46004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanal + CoA + NAD(+) = 2-methylpropanoyl-CoA + H(+) + NADH
REACT:R-CEL-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Caenorhabditis elegans)
RHEA:57697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(I)inamide-[corrinoid adenosyltransferase] => adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate
RHEA:40758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate
RHEA:34444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)
GO:0039594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoribonuclease activity involved in viral induction of host mRNA catabolic process
REACT:R-MMU-77615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR2) (Mus musculus)
RHEA:63077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 2-acetylphloroglucinol + 3 CO2 + 4 CoA
RHEA:68822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-nerolidol + diphosphate => (2Z,6E)-farnesyl diphosphate + H2O
RHEA:62405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyhexadecanoate + O2 => CO2 + H2O + pentadecanoate
REACT:R-HSA-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Homo sapiens)
REACT:R-BTA-140978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex binds FADD (Bos taurus)
REACT:R-BTA-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Bos taurus)
RHEA:22380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol
RHEA:22380	skos:altLabel	"pectin methylesterase"
RHEA:22380	skos:altLabel	"pectin methoxylase"
RHEA:22380	skos:prefLabel	"pectinesterase"
RHEA:22380	skos:altLabel	"pectin demethoxylase"
RHEA:22380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pectinesterase"
REACT:R-BTA-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Bos taurus)
REACT:R-RNO-388981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Kiss receptor GPR54 binds kisspeptin (Rattus norvegicus)
RHEA:34263	skos:prefLabel	"fumigaclavine A dimethylallyltransferase"
RHEA:34263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + fumigaclavine A = diphosphate + fumigaclavine C
RHEA:34263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumigaclavine A dimethylallyltransferase"
RHEA:56327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] <=> 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]
RHEA:36644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	emodin + S-adenosyl-L-methionine => H(+) + questin + S-adenosyl-L-homocysteine
RHEA:50748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juglone = naphthalene-1,2,4,8-tetrol
REACT:R-XTR-6784323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Xenopus tropicalis)
REACT:R-HSA-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Homo sapiens)
REACT:R-MMU-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Mus musculus)
RHEA:56624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)
GO:0030545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling receptor regulator activity
GO:0030545	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	receptor regulator activity
REACT:R-PFA-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Plasmodium falciparum)
REACT:R-HSA-8986985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Homo sapiens)
REACT:R-BTA-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Bos taurus)
REACT:R-RNO-391158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP alpha binds CD47 (Rattus norvegicus)
RHEA:41387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:37799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADH + O2 = 2 H2O + 2 NAD(+)
RHEA:48009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-CoA + H(+) + NADH + O2 => 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)
REACT:R-BTA-9681294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6R binds IL6R inhibitors (Bos taurus)
REACT:R-XTR-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Xenopus tropicalis)
REACT:R-MMU-9647977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT methylates S-Farn RAS proteins (Mus musculus)
REACT:R-DME-193961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Drosophila melanogaster)
REACT:R-XTR-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Xenopus tropicalis)
RHEA:36829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + diosgenin + 2 L-rhamnopyranose => dioscin + 3 H2O
REACT:R-MMU-6799178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 1 binds HP subcomplex to form Intermediate 2 (Mus musculus)
REACT:R-GGA-983146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Gallus gallus)
RHEA:38947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Drosophila melanogaster)
REACT:R-SSC-114558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate Gq (Sus scrofa)
REACT:R-DME-1168633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB translocates from the cytosol to the nucleus (Drosophila melanogaster)
RHEA:50474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetyl-CoA + CO2 + CoA => anthraniloyl-CoA + H(+) + malonyl-CoA
RHEA:29196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + a menaquinone => a menaquinol + orotate
REACT:R-XTR-9033527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Xenopus tropicalis)
GO:0046970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0046970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone H4-K16 deacetylase activity
GO:0046970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent histone H4K16 deacetylase activity
REACT:R-RNO-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Rattus norvegicus)
RHEA:41246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine <=> N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine
REACT:R-SSC-9007447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 forms the PRC1L4 complex (Sus scrofa)
REACT:R-BTA-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Bos taurus)
RHEA:61632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH
RHEA:41567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklavinone + dTDP-beta-L-rhodosamine <=> aclacinomycin T + dTDP + 2 H(+)
REACT:R-DDI-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Dictyostelium discoideum)
GO:0004060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-aminosalicylate N-acetyltransferase activity
GO:0004060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-naphthylamine N-acetyltransferase activity
GO:0004060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleamine N-acetyltransferase activity
GO:0004060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-naphthylamine N-acetyltransferase activity
GO:0004060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:arylamine N-acetyltransferase activity
GO:0004060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylamine acetylase activity
GO:0004060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylamine acetyltransferase activity
GO:0004060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylamine N-acetyltransferase activity
GO:0004060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl CoA-arylamine N-acetyltransferase activity
GO:0004060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminobiphenyl N-acetyltransferase activity
RHEA:63952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid 1-phosphate + H2O = a sphingoid base + phosphate
REACT:R-MMU-71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Mus musculus)
REACT:R-DRE-2160492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4I1:FAD oxidises L-Phe to kPPV (Danio rerio)
REACT:R-GGA-444572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zinc is an agonist of GPR39 (Gallus gallus)
REACT:R-CEL-983194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-1 is a heterotetramer (Caenorhabditis elegans)
RHEA:69619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
REACT:R-SSC-8953339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNPH1 hydrolyses dGMP (Sus scrofa)
RHEA:67149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 => 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]
RHEA:53902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-threonyl-[myosin light chain] => ATP + L-threonyl-[myosin light chain]
RHEA:72191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Homo sapiens)
REACT:R-MTU-879293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formylmycothiol hydrolyzes into mycothiol and formate (Mycobacterium tuberculosis)
GO:0018653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
REACT:R-HSA-9621399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD5 gene expression (Homo sapiens)
REACT:R-HSA-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)
RHEA:69673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + beta-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H2O
RHEA:46388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-2559456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)
RHEA:66892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:36807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + octacosanoyl-CoA = 3-oxo-triacontanoyl-CoA + CO2 + CoA
RHEA:49890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2
RHEA:18231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H(+) + NADH => glycolate + NAD(+)
REACT:R-CFA-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Canis familiaris)
GO:0015532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate:proton symporter activity
GO:0015532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate:proton symporter activity
GO:0015532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate:hydrogen symporter activity
GO:0015532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate:hydrogen symporter activity
REACT:R-HSA-5656105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Homo sapiens)
RHEA:69205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate
REACT:R-CEL-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Caenorhabditis elegans)
REACT:R-RNO-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Rattus norvegicus)
EC:3.6.4.-	skos:prefLabel	"Acting on ATP; involved in cellular and subcellular movement"
EC:3.6.4.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on ATP; involved in cellular and subcellular movement"
GO:0050288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbose dehydrogenase activity
GO:0050288	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-sorbose:acceptor 5-oxidoreductase activity
GO:0050288	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-sorbose:(acceptor) 5-oxidoreductase activity
RHEA:18003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O
RHEA:54867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + sulcatone <=> 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)
REACT:R-CFA-5694441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1D phosphorylates SEC23 (Canis familiaris)
REACT:R-CFA-420582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin-1 trans heterodimer interaction (Canis familiaris)
REACT:R-HSA-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Homo sapiens)
REACT:R-SCE-5423117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates MeK21-histone H4 (Saccharomyces cerevisiae)
REACT:R-HSA-9665411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)
REACT:R-MMU-5683967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Mus musculus)
REACT:R-CFA-8987179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Canis familiaris)
RHEA:44050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O
REACT:R-HSA-1791123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of KDELR3 (Homo sapiens)
RHEA:16607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+) => dodecanoyl-CoA + H2O + oxaloacetate
RHEA:51408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
RHEA:54898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate => (10Z,15Z)-12-oxophytodienoate + ATP + CoA
RHEA:49602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + octanedioyl-CoA => ATP + CoA + octanedioate
EC:3.1.4.56	skos:prefLabel	"7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase"
EC:3.1.4.56	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase"
REACT:R-XTR-8875443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates LRIG1 (Xenopus tropicalis)
REACT:R-DRE-9011985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Danio rerio)
REACT:R-GGA-5666216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds TAX1BP3 (Gallus gallus)
REACT:R-CEL-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Caenorhabditis elegans)
REACT:R-DRE-1604368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of bound proMMP2 (Danio rerio)
REACT:R-CEL-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Caenorhabditis elegans)
RHEA:49455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O <=> 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol
REACT:R-CEL-72676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF3 and eIF1A bind to the 40S subunit (Caenorhabditis elegans)
REACT:R-DDI-9035227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN2 binds CysS248-MPST (Dictyostelium discoideum)
RHEA:15846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP
REACT:R-MMU-1855205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Mus musculus)
REACT:R-HSA-141316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Homo sapiens)
REACT:R-RNO-9749197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 binds to H4K20me2 (Rattus norvegicus)
RHEA:21564	skos:prefLabel	"acetyl-CoA C-acyltransferase"
RHEA:21564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetyl-CoA C-acyltransferase"
RHEA:21564	skos:altLabel	"3-ketoacyl-CoA thiolase"
RHEA:21564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA
RHEA:21564	skos:altLabel	"beta-ketothiolase"
RHEA:67438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine
GO:0008312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7S RNA binding
REACT:R-DME-1483063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG and CDP-DAG are converted to CL by CRLS1 (Drosophila melanogaster)
REACT:R-RNO-2395818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)
REACT:R-BTA-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Bos taurus)
REACT:R-HSA-5663273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RORA, EP300, PPARGC1A bind NR1D1 gene (Homo sapiens)
RHEA:71230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + selenocyanate(out) <=> 2 Na(+)(in) + selenocyanate(in)
RHEA:42661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose
RHEA:23893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitropropanoate + NADP(+) => 3-nitroacrylate + H(+) + NADPH
REACT:R-BTA-9706298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CSK (Bos taurus)
REACT:R-SCE-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Saccharomyces cerevisiae)
REACT:R-HSA-354149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
RHEA:42379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate
REACT:R-MMU-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Mus musculus)
GO:0052878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,8-linoleate diol synthase (bifunctional enzyme) activity
GO:0052878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,8-LDS (bifunctional enzyme) activity
GO:0052878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-LDS (bifunctional enzyme) activity
GO:0052878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate diol synthase activity
GO:0052878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleate 8R-lipoxygenase activity
GO:0052878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-linoleate diol synthase (bifunctional enzyme) activity
REACT:R-MMU-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)
REACT:R-SSC-194718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Sus scrofa)
RHEA:30062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + fumarate <=> orotate + succinate
GO:0016426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (adenine) methyltransferase activity
REACT:R-MMU-114552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate G12/13 (Mus musculus)
RHEA:23150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + propanoyl phosphate => ATP + propanoate
RHEA:53270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylulose => L-ribulose
REACT:R-XTR-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Xenopus tropicalis)
RHEA:67551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O <=> [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-PFA-5638157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)
REACT:R-BTA-6807224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-BGLAP to BGLAP (Bos taurus)
REACT:R-CEL-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Caenorhabditis elegans)
RHEA:38353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + H(+) + NADH => (R)-3-phenyllactate + NAD(+)
REACT:R-DRE-9011595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Danio rerio)
REACT:R-DRE-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Danio rerio)
REACT:R-BTA-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Bos taurus)
REACT:R-DRE-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Danio rerio)
RHEA:32208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (3Z)-2-oxohex-3-enedioate
REACT:R-MMU-75090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR1 homodimer to dsRNA duplex (Mus musculus)
RHEA:36602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + NAD(+) <=> NADH + sulfur
RHEA:19636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) <=> (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)
REACT:R-DME-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Drosophila melanogaster)
RHEA:49423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + valienone <=> ADP + H(+) + valienone 7-phosphate
REACT:R-CEL-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Caenorhabditis elegans)
REACT:R-SSC-191654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-src associates with Cx43 in gap junctions (Sus scrofa)
REACT:R-XTR-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)
GO:0043177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organic acid binding
REACT:R-HSA-442749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the nucleus (Homo sapiens)
GO:0004787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPPase activity
GO:0004787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine-diphosphatase activity
GO:0004787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin pyrophosphatase activity
GO:0004787	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	thiamine diphosphatase activity
GO:0004787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine pyrophosphatase activity
GO:0004787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine diphosphate phosphatase activity
GO:0004787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiaminpyrophosphatase activity
GO:0004787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin-pyrophosphatase activity
GO:0004787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine diphosphate = H(+) + phosphate + thiamine phosphate
REACT:R-DRE-430096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds filamin (Danio rerio)
RHEA:12578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose
REACT:R-DRE-9018747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GEFs activate RHOQ (Danio rerio)
REACT:R-DME-433101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Drosophila melanogaster)
REACT:R-RNO-3249378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING recruits TBK1 and STAT6 (Rattus norvegicus)
RHEA:31432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-beta-santalene + diphosphate
RHEA:28348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromonapterin 3'-triphosphate => 7,8-dihydroneopterin 3'-triphosphate
REACT:R-XTR-9648268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A antagonists (Xenopus tropicalis)
REACT:R-MMU-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Mus musculus)
REACT:R-HSA-8849463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates SFPQ (Homo sapiens)
RHEA:59687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaose + O2 <=> D-maltohexaono-1,5-lactone + H2O2
REACT:R-CFA-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Canis familiaris)
REACT:R-RNO-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Rattus norvegicus)
RHEA:43374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+) => an N-acylsphing-4-enine + dTDP-alpha-D-glucose
RHEA:19401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol + NAD(+) = formaldehyde + H(+) + NADH
RHEA:19401	skos:prefLabel	"methanol dehydrogenase"
RHEA:19401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methanol dehydrogenase"
REACT:R-HSA-2900765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants (Homo sapiens)
REACT:R-BTA-3000120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLIF binds RCbl (Bos taurus)
RHEA:40612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trihexanoylglycerol => 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate
REACT:R-SCE-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Saccharomyces cerevisiae)
RHEA:68504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = (Z)-beta-farnesene + diphosphate
REACT:R-SSC-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Sus scrofa)
EC:1.1.98.-	skos:prefLabel	"With other, known, acceptors"
EC:1.1.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
REACT:R-XTR-8987033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Xenopus tropicalis)
REACT:R-CEL-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Caenorhabditis elegans)
RHEA:44059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA
REACT:R-HSA-8876615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB13 GEFs exchange GTP for GDP on RAB13 (Homo sapiens)
RHEA:15401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-alpha-D-glucose = a dolichyl beta-D-glucosyl phosphate + UDP
RHEA:15401	skos:prefLabel	"dolichyl-phosphate beta-glucosyltransferase"
RHEA:15401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-phosphate beta-glucosyltransferase"
REACT:R-MMU-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Mus musculus)
RHEA:24037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-phosphate + ATP => a ribonucleoside 5'-diphosphate + ADP
REACT:R-DME-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Drosophila melanogaster)
REACT:R-RNO-5654222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PLCG1 (Rattus norvegicus)
RHEA:50770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine
RHEA:67064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + asnovolin K = A + asnovolin A
RHEA:13220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + succinate semialdehyde <=> 2 H(+) + NADH + succinate
RHEA:69881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:72876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A7 + malonyl-CoA => anthocyanin A9 + CoA
RHEA:48055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + dermatan <=> n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)
REACT:R-DRE-2046097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)
REACT:R-GGA-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Gallus gallus)
REACT:R-CFA-1667005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Canis familiaris)
REACT:R-DDI-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Dictyostelium discoideum)
REACT:R-DRE-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Danio rerio)
REACT:R-XTR-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Xenopus tropicalis)
RHEA:37927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
RHEA:21015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
GO:0045181	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate synthase activity, NADH or NADPH as acceptor
GO:0045181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate synthase activity, NAD(P)H as acceptor
RHEA:35956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B => 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-1483002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to 1-acyl GO3P by GNPAT (Xenopus tropicalis)
RHEA:28357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + FAD + H(+) <=> (2E)-decenoyl-CoA + FADH2
REACT:R-HSA-6802908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS mutants bind inactive RAF (Homo sapiens)
REACT:R-SCE-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Saccharomyces cerevisiae)
REACT:R-GGA-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Gallus gallus)
RHEA:30679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose + H2O = beta-D-glucose + D-glucose
REACT:R-MMU-159790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Mus musculus)
REACT:R-BTA-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Bos taurus)
RHEA:66503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
EC:2.3.1.47	skos:prefLabel	"8-amino-7-oxononanoate synthase"
EC:2.3.1.47	skos:altLabel	"7-KAP synthetase"
EC:2.3.1.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-amino-7-oxononanoate synthase"
EC:2.3.1.47	skos:altLabel	"8-amino-7-ketopelargonate synthase"
EC:2.3.1.47	skos:altLabel	"7-keto-8-aminopelargonic acid synthetase"
EC:2.3.1.47	skos:altLabel	"AONS"
REACT:R-MMU-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Mus musculus)
GO:0047781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-citrulline N5-carbamoyldihydrolase activity
GO:0047781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrulline ureidase activity
GO:0047781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrullinase activity
GO:0047781	skos:prefLabel	"citrullinase"
GO:0047781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-citrulline 5-N-carbamoyldihydrolase activity
GO:0047781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citrullinase"
GO:0047781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrulline hydrolase activity
GO:0047781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + L-citrulline = CO2 + L-ornithine + NH4(+)
REACT:R-DME-3165230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC52A1,2,3 transport RIB from extracellular region to cytosol (Drosophila melanogaster)
RHEA:23496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-hydroxypentanoate CoA-transferase"
RHEA:23496	skos:altLabel	"5-hydroxyvalerate CoA-transferase"
RHEA:23496	skos:prefLabel	"5-hydroxypentanoate CoA-transferase"
RHEA:23496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate
REACT:R-GGA-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Gallus gallus)
REACT:R-RNO-9656893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1MW binds 11cRAL (Rattus norvegicus)
REACT:R-HSA-5603251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ACTH does not bind MCR2 (Homo sapiens)
RHEA:17302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]
RHEA:61378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O
REACT:R-MMU-428262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Mus musculus)
RHEA:14456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(phosphooxy)-L-threonine + NAD(+) <=> (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH
REACT:R-HSA-975311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Homo sapiens)
GO:0090587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-glucosamine phosphotransferase system transporter activity
RHEA:55693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphoceramide + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)
REACT:R-RNO-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Rattus norvegicus)
RHEA:65414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP(out) + NAD(+)(in) => dAMP(in) + NAD(+)(out)
RHEA:72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin => O2 + reduced [NADPH--hemoprotein reductase] + secologanin
RHEA:52418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-D-erythronate + H(+)
REACT:R-CFA-8953398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIR oxygenates quercetin (Canis familiaris)
REACT:R-HSA-3371353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble TNF-α binds TNFR1 (Homo sapiens)
RHEA:57725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 Na(+)(in) + oxaloacetate => CO2 + 2 Na(+)(out) + pyruvate
RHEA:40092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxyhexacosanoate + NAD(+) => 26-oxohexacosanoate + H(+) + NADH
RHEA:30892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + thiosulfate => acetate + H(+) + S-sulfo-L-cysteine
REACT:R-CEL-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)
REACT:R-SPO-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Schizosaccharomyces pombe)
REACT:R-BTA-211959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A43 6b-hydroxylates TEST (Bos taurus)
REACT:R-SSC-5682709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI4 binds ADAM22,23,11 (Sus scrofa)
RHEA:65179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + protoaustinoid A <=> AH2 + protoaustinoid B
REACT:R-DRE-4086088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO1 (Danio rerio)
RHEA:52806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:45458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + ethanolamine => H2O + N-dodecanoylethanolamine
EC:3.4.24.36	skos:prefLabel	"leishmanolysin"
EC:3.4.24.36	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leishmanolysin"
EC:3.4.24.36	skos:altLabel	"promastigote surface endopeptidase"
EC:3.4.24.36	skos:altLabel	"glycoprotein gp63"
REACT:R-SSC-159819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Sus scrofa)
RHEA:54060	skos:prefLabel	"(2Z,6E)-hedycaryol synthase"
RHEA:54060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2Z,6E)-hedycaryol synthase"
RHEA:54060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate
REACT:R-RNO-5684052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates MDC1 (Rattus norvegicus)
REACT:R-SSC-8877192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds FOXP3 (Sus scrofa)
RHEA:37515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-DRE-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Danio rerio)
RHEA:10289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-rhamnono-1,4-lactone => H(+) + L-rhamnonate
REACT:R-HSA-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Homo sapiens)
REACT:R-CEL-917744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA loaded synaptic vesicle Docking and Priming (Caenorhabditis elegans)
REACT:R-XTR-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Xenopus tropicalis)
RHEA:29401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+) + IMP => H2O + ITP
RHEA:45411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H(+) + NADH <=> dodecanoyl-CoA + NAD(+)
REACT:R-RNO-158756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Rattus norvegicus)
REACT:R-CFA-380508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NuMA to the centrosomes (Canis familiaris)
RHEA:58611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-decanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine
REACT:R-MMU-349657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)
RHEA:59156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]
REACT:R-DME-1676162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Drosophila melanogaster)
REACT:R-HSA-5632648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)
REACT:R-HSA-8854052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the SCF-FBXL7 complex (Homo sapiens)
REACT:R-MMU-5689972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 deubiquitinates MDM2,MDM4 (Mus musculus)
RHEA:15924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol
RHEA:44652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine
REACT:R-DRE-158164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Danio rerio)
RHEA:36234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
REACT:R-HSA-9029521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the ABCG5 gene (Homo sapiens)
REACT:R-XTR-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Xenopus tropicalis)
REACT:R-RNO-8849157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Rattus norvegicus)
REACT:R-RNO-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Rattus norvegicus)
RHEA:59487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite + 2 Fe(III)-[cytochrome c] + H2O <=> arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)
RHEA:27542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde
REACT:R-RNO-9617996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Rattus norvegicus)
RHEA:48597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoylglycerol + H2O => decanoate + decanoylglycerol + H(+)
REACT:R-MMU-3640872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP34 deubiquitinates AXIN1,AXIN2 (Mus musculus)
REACT:R-PFA-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Plasmodium falciparum)
RHEA:26034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:25655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetone + CO2 => (2S)-2-amino-3-oxobutanoate + H(+)
REACT:R-HSA-180710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rev:importin beta:B23 recruited to the nuclear pore (Homo sapiens)
RHEA:69345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-but-1-en-1-SO-peroxol => (Z)-butanethial oxide
REACT:R-DRE-158756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Danio rerio)
REACT:R-BTA-448603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33:IL1RL1 binds IL1RAP-1 (Bos taurus)
RHEA:40302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0004654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyribonucleotide nucleotidyltransferase activity
GO:0004654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyribonucleotide:phosphate nucleotidyltransferase activity
GO:0004654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide phosphorylase activity
GO:0004654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyribonucleotide phosphorylase activity
GO:0004654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside diphosphate:polynucleotidyl transferase activity
RHEA:19720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-phenylalanine <=> 2-phenylethylamine + CO2
RHEA:40687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol = 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:36776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-GGA-201712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin:TCF associates with BCL9 and PYGO (Gallus gallus)
RHEA:26185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate
REACT:R-MMU-2187309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer binds SP1 (Mus musculus)
RHEA:25953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde => 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate
REACT:R-XTR-71825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Xenopus tropicalis)
REACT:R-CFA-140847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Canis familiaris)
GO:0047307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diaminobutyrate-pyruvate aminotransferase activity
GO:0047307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diaminobutyrate-pyruvate transaminase activity
GO:0047307	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diaminobutyrate--pyruvate aminotransferase activity
GO:0047307	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-diaminobutyric acid transaminase activity
GO:0047307	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2,4-diaminobutanoate:pyruvate aminotransferase activity
REACT:R-CFA-420977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca permeable AMPA receptor ligand binding (Canis familiaris)
RHEA:54676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-kolavenyl diphosphate synthase"
RHEA:54676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate
RHEA:54676	skos:prefLabel	"(+)-kolavenyl diphosphate synthase"
REACT:R-GGA-77591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Gallus gallus)
REACT:R-CEL-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Caenorhabditis elegans)
REACT:R-MMU-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Mus musculus)
RHEA:45021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine
REACT:R-HSA-9698926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCMV Genome Replication Completion (Homo sapiens)
REACT:R-SSC-1169402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of E2 conjugating enzymes (Sus scrofa)
REACT:R-HSA-6798528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Mn2+ (Homo sapiens)
RHEA:56570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside IV3GalNAc-Gb4Cer + H(+) + UDP => globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine
RHEA:39860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol
RHEA:70754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
RHEA:40462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 <=> (2E)-pristenoyl-CoA + H2O2
RHEA:33207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-glutamate + NADPH = ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate
RHEA:63343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-amino acyl-L-seryl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate
REACT:R-RNO-8987255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Rattus norvegicus)
RHEA:32207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-2-hydroxyhexa-2,4-dienedioate = (3Z)-2-oxohex-3-enedioate
GO:0002935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (adenine-C2-)-methyltransferase activity
REACT:R-BTA-8849157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Bos taurus)
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylaminoimidazole-succinocarboxamide synthetase activity
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PurC
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylaminoimidazole-succinocarboxamide synthase activity
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SAICAR synthase activity
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SAICAR synthetase activity
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Homo sapiens)
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SAICARs activity
GO:0004639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity
REACT:R-XTR-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Xenopus tropicalis)
GO:0050262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosylnicotinamide kinase activity
GO:0050262	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:N-ribosylnicotinamide 5'-phosphotransferase activity
GO:0050262	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribosylnicotinamide kinase (phosphorylating)
GO:0050262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide riboside kinase activity
RHEA:57322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein] => acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein]
REACT:R-HSA-9648883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T-EIF2AK1:ferriheme dimer autophosphorylates (Homo sapiens)
REACT:R-RNO-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Rattus norvegicus)
REACT:R-CFA-2423785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR:atREs binds apoE and HSPG (Canis familiaris)
REACT:R-CFA-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Canis familiaris)
REACT:R-BTA-2028670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Bos taurus)
REACT:R-BTA-2059926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPHP4 protein binds LATS proteins (Bos taurus)
REACT:R-MMU-9647643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds bacterial cardiolipin (Mus musculus)
REACT:R-RNO-3322431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds TLE (Rattus norvegicus)
RHEA:37659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methanol O-anthraniloyltransferase"
RHEA:37659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate
RHEA:37659	skos:prefLabel	"methanol O-anthraniloyltransferase"
REACT:R-HSA-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)
RHEA:65259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + verruculide C <=> A + H2O + verruculide C epoxide
REACT:R-CFA-2203516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-1-Microglobulin is cleaved (Canis familiaris)
REACT:R-MMU-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Mus musculus)
REACT:R-BTA-873927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of STAT1 dimer from active receptor unit (Bos taurus)
GO:0047754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline sulfotransferase activity
GO:0047754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:choline sulfotransferase activity
GO:0047754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline sulphotransferase activity
GO:0047754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline sulphokinase activity
REACT:R-BTA-9009554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer:SDC1 binds CSF1R (Bos taurus)
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP-mannose-1-phosphate guanylyltransferase activity
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	mannose-1-phosphate guanylyltransferase activity
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:mannose-1-phosphate guanylyltransferase activity
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannose 1-phosphate guanylyltransferase (guanosine triphosphate)
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-diphospho-D-mannose pyrophosphorylase activity
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose pyrophosphorylase activity
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose pyrophosphorylase activity
GO:0004475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose-1-phosphate guanylyltransferase (GTP) activity
REACT:R-DME-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Drosophila melanogaster)
RHEA:69263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate
REACT:R-MMU-5649764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Mus musculus)
RHEA:39369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH
REACT:R-SSC-8981606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin binds oxygen (Sus scrofa)
REACT:R-DME-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)
REACT:R-BTA-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Bos taurus)
REACT:R-HSA-1247922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCT transforms gGluCys to OPRO (Homo sapiens)
GO:0047124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythro-3,5-diaminohexanoate dehydrogenase activity
GO:0047124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)
GO:0047124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3,5-diaminohexanoate dehydrogenase activity
RHEA:12688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 mycothiol + NADP(+) <=> H(+) + mycothione + NADPH
REACT:R-XTR-2514867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Xenopus tropicalis)
RHEA:59658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotriono-1,5-lactone + H2O2 => D-cellotriose + O2
RHEA:33200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + NAD(+) => butanal + H(+) + NADH
RHEA:23410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + precorrin-6A => NADP(+) + precorrin-6B
RHEA:24077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-Delta(5)-steroid + NAD(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADH
REACT:R-DRE-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Danio rerio)
RHEA:41169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
RHEA:32431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-menthone + H(+) + NADPH + O2 = (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)
RHEA:29239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + uracil(in) = H(+)(out) + uracil(out)
REACT:R-DRE-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Danio rerio)
RHEA:14766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine h + O2 => CO2 + excited coelenteramide h monoanion + H(+) + hnu
RHEA:34067	skos:prefLabel	"decaprenyl-phosphate phosphoribosyltransferase"
RHEA:34067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate = diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate
RHEA:34067	skos:altLabel	"5-phospho-alpha-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase"
RHEA:34067	skos:altLabel	"5-phospho-alpha-D-ribose 1-pyrophosphate:decaprenyl phosphate 5-phosphoribosyltransferase"
RHEA:34067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"decaprenyl-phosphate phosphoribosyltransferase"
RHEA:34067	skos:altLabel	"DPPR synthase"
REACT:R-CEL-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Caenorhabditis elegans)
RHEA:61596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbD protein]-dithiol + [thioredoxin]-disulfide = [DsbD protein]-disulfide + [thioredoxin]-dithiol
RHEA:63534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin-(1-9) + L-leucine => angiotensin I + H2O
RHEA:29399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ITP = diphosphate + H(+) + IMP
RHEA:38108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-galactonate => L-glyceraldehyde + pyruvate
REACT:R-HSA-1678841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Homo sapiens)
REACT:R-GGA-9038029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxysterol binds ESR1, ESR2 (Gallus gallus)
REACT:R-GGA-5692764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 binds CCND3 (Gallus gallus)
REACT:R-HSA-2162191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase (Homo sapiens)
RHEA:68840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate
REACT:R-BTA-4167509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial BTD hydrolyses BCTN (Bos taurus)
REACT:R-SCE-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Saccharomyces cerevisiae)
REACT:R-BTA-6786096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Bos taurus)
REACT:R-HSA-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)
RHEA:48635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O
EC:3.4.24.7	skos:altLabel	"matrix metalloproteinase 1"
EC:3.4.24.7	skos:prefLabel	"interstitial collagenase"
EC:3.4.24.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"interstitial collagenase"
EC:3.4.24.7	skos:altLabel	"vertebrate collagenase"
REACT:R-HSA-177491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin-coated vesicle (Homo sapiens)
REACT:R-XTR-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Xenopus tropicalis)
RHEA:44849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-tetradecenoyl-(R)-carnitine
RHEA:11172	skos:altLabel	"methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase"
RHEA:11172	skos:altLabel	"5-methyltetrahydrofolate--homocysteine transmethylase"
RHEA:11172	skos:altLabel	"methionine synthetase"
RHEA:11172	skos:altLabel	"B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase"
RHEA:11172	skos:altLabel	"methionine synthase (cobalamin-dependent)"
RHEA:11172	skos:altLabel	"cobalamin-dependent methionine synthase"
RHEA:11172	skos:altLabel	"N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase"
RHEA:11172	skos:altLabel	"N(5)-methyltetrahydrofolate methyltransferase"
RHEA:11172	skos:altLabel	"vitamin B12 methyltransferase"
RHEA:11172	skos:altLabel	"tetrahydropteroylglutamate methyltransferase"
RHEA:11172	skos:altLabel	"tetrahydropteroylglutamic methyltransferase"
RHEA:11172	skos:altLabel	"tetrahydrofolate methyltransferase"
RHEA:11172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
RHEA:11172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionine synthase"
RHEA:11172	skos:altLabel	"N-methyltetrahydrofolate:L-homocysteine methyltransferase"
RHEA:11172	skos:altLabel	"5-methyltetrahydrofolate--homocysteine S-methyltransferase"
RHEA:11172	skos:prefLabel	"methionine synthase"
RHEA:11172	skos:altLabel	"N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase"
REACT:R-BTA-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Bos taurus)
REACT:R-GGA-5694417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Gallus gallus)
REACT:R-DRE-265422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaEbeta7 with Cadherin-1 (Danio rerio)
RHEA:39962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate
REACT:R-MMU-1112602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)
REACT:R-HSA-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Homo sapiens)
REACT:R-RNO-9700171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates PLCG1 (Rattus norvegicus)
RHEA:27943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-D-aspartate => NH4(+) + oxaloacetate
REACT:R-DRE-5654620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)
REACT:R-CFA-396996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs binds G-protein Gq (Canis familiaris)
REACT:R-MMU-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Mus musculus)
REACT:R-HSA-8865491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene (Homo sapiens)
GO:0003853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylacyl-CoA dehydrogenase activity
GO:0003853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methyl branched chain acyl-CoA dehydrogenase activity
GO:0003853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methyl-branched-chain-enoyl-CoA reductase activity
GO:0003853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain acyl-CoA dehydrogenase activity
RHEA:13018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + UMP => 5-phospho-alpha-D-ribose 1-diphosphate + uracil
REACT:R-CFA-2327738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Canis familiaris)
REACT:R-HSA-9036970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 activates RAS through SHC1 (Homo sapiens)
RHEA:59712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraono-1,5-lactone + H2O = D-maltotetraonate + H(+)
REACT:R-XTR-5218818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Xenopus tropicalis)
RHEA:51516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + S-adenosyl-L-methionine = (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-508513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B binds JAK3 (Mus musculus)
EC:3.4.23.36	skos:altLabel	"SPase II"
EC:3.4.23.36	skos:altLabel	"lipoprotein signal peptidase"
EC:3.4.23.36	skos:altLabel	"prolipoprotein-signal peptidase"
EC:3.4.23.36	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"signal peptidase II"
EC:3.4.23.36	skos:prefLabel	"signal peptidase II"
EC:3.4.23.36	skos:altLabel	"bacterial leader peptidase I"
EC:3.4.23.36	skos:altLabel	"premurein-leader peptidase"
REACT:R-MMU-2161890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Mus musculus)
RHEA:17550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine
RHEA:72866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-cAAG + H2O <=> G[3'-5']pA[3'-5']pAp[3'] + H(+)
REACT:R-DRE-5138459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A:FZD4 is endocytosed (Danio rerio)
REACT:R-SSC-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Sus scrofa)
REACT:R-MMU-202704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaXbeta2 binds JAM3 (Mus musculus)
REACT:R-BTA-420582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin-1 trans heterodimer interaction (Bos taurus)
REACT:R-SSC-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Sus scrofa)
REACT:R-HSA-5624131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B binds myristoylated proteins (Homo sapiens)
REACT:R-BTA-9696323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNRs bind CNR agonists (Bos taurus)
REACT:R-MMU-8938930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF2 (Mus musculus)
RHEA:34428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-lariciresinol + NADP(+) => (-)-pinoresinol + H(+) + NADPH
REACT:R-GGA-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Gallus gallus)
RHEA:13597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-diguanidinobutane + H2O = agmatine + urea
RHEA:13597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diguanidinobutanase"
RHEA:13597	skos:prefLabel	"diguanidinobutanase"
REACT:R-MMU-2997616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Mus musculus)
REACT:R-BTA-265301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticotropin cleavage from POMC (Bos taurus)
REACT:R-BTA-211948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 can N-demethylate loperamide (Bos taurus)
RHEA:47842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate => [5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine
REACT:R-HSA-1592233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates PPARGC1A (Homo sapiens)
REACT:R-BTA-111915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK4 autophosphorylates (Bos taurus)
RHEA:63324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-HSA-5686704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates DCLRE1C (Homo sapiens)
REACT:R-XTR-1971487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHSY3 transfer GalNAc to chondroitin (Xenopus tropicalis)
RHEA:49759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O2 + protoviolaceinate <=> CO2 + H2O + proviolacein
RHEA:29738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butane-1-sulfonate + FMNH2 + O2 <=> butanal + FMN + 2 H(+) + H2O + sulfite
RHEA:66682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + coproporphyrinogen III(out) + H(+) + phosphate => ATP + coproporphyrinogen III(in) + H2O
RHEA:58655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifamycin SV ortho-naphthoquinone carboxamide <=> rifamycin SV para-naphthoquinone carboxamide
REACT:R-MMU-8952128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TP53 (Mus musculus)
RHEA:64166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + L-alanine => 2-methyl-L-serine
REACT:R-DDI-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Dictyostelium discoideum)
REACT:R-CFA-917839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-Transferrin dissociates from the receptor complex (Canis familiaris)
REACT:R-SPO-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Schizosaccharomyces pombe)
GO:0031864	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	EP1 subtype prostaglandin E2 receptor ligand
GO:0031864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostanoid EP1 receptor binding
GO:0031864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP1 subtype prostaglandin E2 receptor binding
REACT:R-CFA-8858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF9 binds TNFRSF9 (Canis familiaris)
REACT:R-CEL-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Caenorhabditis elegans)
RHEA:21174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate + H(+) + NADH => L-idonate + NAD(+)
REACT:R-DDI-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Dictyostelium discoideum)
RHEA:28694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + a ubiquinone <=> a ubiquinol + orotate
REACT:R-HSA-5635868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-GLI is degraded by the proteasome (Homo sapiens)
REACT:R-XTR-177923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sustained activation of SRC kinase by SHP2 (Xenopus tropicalis)
REACT:R-CFA-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Canis familiaris)
RHEA:68483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxyhexadecanoate + H(+) <=> CO2 + H2O + pentadecanal
REACT:R-HSA-5696564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP25 deubiquitinates DDX58 (Homo sapiens)
REACT:R-DRE-191656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Closure of gap junction (Danio rerio)
REACT:R-SSC-71590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)
GO:0043783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, oxidizing metal ions with flavin as acceptor
GO:0043783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a flavin as acceptor"
GO:0043783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, reducing metal ions, flavin as acceptor
GO:0043783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on metal ions, flavin as acceptor
GO:0043783	skos:prefLabel	"With a flavin as acceptor"
RHEA:28161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
REACT:R-DDI-170672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Dictyostelium discoideum)
RHEA:16675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphate + pyruvate => 3-phosphonopyruvate + H2O
REACT:R-MMU-9668597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase:primase binds G-strand of the telomere (Mus musculus)
EC:4.1.1.102	skos:altLabel	"ferulic acid decarboxylase"
EC:4.1.1.102	skos:prefLabel	"phenacrylate decarboxylase"
EC:4.1.1.102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenacrylate decarboxylase"
REACT:R-HSA-211289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein (Homo sapiens)
REACT:R-SSC-419334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melatonin receptors can bind melatonin (Sus scrofa)
EC:3.4.23.16	skos:altLabel	"human immunodeficiency virus type 1 protease"
EC:3.4.23.16	skos:prefLabel	"HIV-1 retropepsin"
EC:3.4.23.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"HIV-1 retropepsin"
REACT:R-HSA-1980122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX binds NOTCH1 (Homo sapiens)
GO:0102732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity
RHEA:36723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + A + H2O = 2-phenylacetaldehyde + AH2 + NH4(+)
RHEA:46785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:70572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + Na(+)(out) => D-glucose(in) + Na(+)(in)
RHEA:71448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(in) + Na(+)(in) => D-alanine(out) + Na(+)(out)
REACT:R-MMU-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Mus musculus)
REACT:R-CFA-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Canis familiaris)
RHEA:10466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n acetate + chitosan => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O
REACT:R-BTA-1470010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of STATs (Bos taurus)
REACT:R-CFA-9033961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Canis familiaris)
GO:0000107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazole glycerol phosphate synthase activity
GO:0000107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazoleglycerol-phosphate synthase activity
GO:0000107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazoleglycerol phosphate synthase activity
GO:0000107	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamine amidotransferase:cyclase activity
GO:0000107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazole-glycerol-phosphate synthase activity
REACT:R-DRE-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Danio rerio)
REACT:R-XTR-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Xenopus tropicalis)
REACT:R-HSA-373813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
REACT:R-XTR-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Xenopus tropicalis)
RHEA:26473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + 16-hydroxyhexadecanoate <=> 16-feruloyloxyhexadecanoate + CoA
RHEA:39673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (9Z)-hexadecenoyl-CoA + AH2 + O2
REACT:R-CFA-2213208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type X collagen associates with collagen type II fibrils (Canis familiaris)
REACT:R-BTA-83723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Bos taurus)
REACT:R-DDI-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Dictyostelium discoideum)
RHEA:11789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate + NAD(+) => H(+) + NADH + NH4(+) + oxaloacetate
REACT:R-MMU-981832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMUR2 binds neuromedin-S (Mus musculus)
REACT:R-RNO-2429719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCPH1 sequesters condensin II (Rattus norvegicus)
REACT:R-BTA-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Bos taurus)
RHEA:35637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose
REACT:R-DDI-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Dictyostelium discoideum)
RHEA:46113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
GO:0047999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylamine:NAD+ oxidoreductase activity
GO:0047999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:hyponitrite oxidoreductase activity
GO:0047999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyponitrite reductase activity
GO:0047999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2:hyponitrite oxidoreductase activity
RHEA:48027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tripropanoylglycerol + H2O <=> dipropanoylglycerol + H(+) + propanoate
RHEA:68520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = beta-acoradiene + diphosphate
RHEA:29164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) => 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)
RHEA:49563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate <=> (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate
RHEA:23547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP
GO:0030429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-kynurenine = anthranilate + H(+) + L-alanine
GO:0030429	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-kynurenine hydrolase activity
GO:0030429	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenine hydrolase activity
GO:0030429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynureninase activity
RHEA:47581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GT2 (d18:1(4E)) + H(+) + UDP
REACT:R-BTA-397835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:Gq (active) dissociate (Bos taurus)
REACT:R-BTA-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Bos taurus)
REACT:R-XTR-2028651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Xenopus tropicalis)
RHEA:51522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine
REACT:R-DRE-3858495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits GTP-bound RHOA (Danio rerio)
RHEA:17723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-BTA-3788061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by ADAM8 (Bos taurus)
REACT:R-CFA-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Canis familiaris)
RHEA:11214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formamidobenzaldehyde => indole + O2
RHEA:14012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dimethylallyl diphosphate <=> (R,R)-chrysanthemyl diphosphate + diphosphate
RHEA:54501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate => beta-geranylfarnesene + diphosphate
REACT:R-SSC-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)
RHEA:53401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate
GO:0047312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine:pyruvate transaminase activity
GO:0047312	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phenylalanine(histidine) aminotransferase activity
GO:0047312	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine:pyruvate aminotransferase activity
GO:0047312	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phenylalanine (histidine) aminotransferase activity
GO:0047312	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phenylalanine(histidine) transaminase activity
GO:0047312	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phenylalanine(histidine):pyruvate aminotransferase activity
GO:0047312	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine aminotransferase activity
GO:0047312	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-phenylalanine(L-histidine):pyruvate aminotransferase activity
GO:0047312	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidine:pyruvate aminotransferase activity
GO:0047312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine:pyruvate aminotransferase activity
RHEA:41157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+) => 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-HSA-199566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR3DL1 interacting with HLA Bw4 (Homo sapiens)
REACT:R-DME-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)
REACT:R-GGA-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Gallus gallus)
REACT:R-DME-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Drosophila melanogaster)
RHEA:18272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (S)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH
REACT:R-HSA-9697064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lprG binds to LAM,LM (Homo sapiens)
REACT:R-HSA-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)
REACT:R-CEL-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Caenorhabditis elegans)
REACT:R-XTR-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Xenopus tropicalis)
RHEA:32493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-8850794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK5 (Bos taurus)
RHEA:30653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoin + CO2 + H2O2 => 2 H2O + O2 + urate
REACT:R-GGA-451634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
REACT:R-HSA-389424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The orphan QRFP receptor can bind neuropeptide QRFP (Homo sapiens)
RHEA:20154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arabinose => ADP + beta-L-arabinose 1-phosphate + H(+)
REACT:R-DDI-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Dictyostelium discoideum)
RHEA:72335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate = 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
REACT:R-CEL-2161187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)
RHEA:30049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetate + 2 H(+) + NADH => chloroacetaldehyde + H2O + NAD(+)
REACT:R-BTA-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Bos taurus)
RHEA:64802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+) => NAD(+) + S-(2-aminoethyl)-L-cysteine
RHEA:27592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate + ADP + H(+) + phosphate => (R)-pantoate + ATP + beta-alanine
REACT:R-MMU-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
REACT:R-SCE-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Saccharomyces cerevisiae)
RHEA:39654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)
REACT:R-RNO-5624951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNPO1 binds KIF17 dimer (Rattus norvegicus)
RHEA:32731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)
REACT:R-CFA-9023632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)
REACT:R-GGA-204947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF migrates to the nucleus (Gallus gallus)
RHEA:70799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(in) + L-ornithine(out) = L-lysine(out) + L-ornithine(in)
REACT:R-HSA-9694317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)
REACT:R-SSC-9678561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Sus scrofa)
REACT:R-XTR-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Xenopus tropicalis)
REACT:R-HSA-9666425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)
GO:0047405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine nucleotide N-ribosidase activity
GO:0047405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity
GO:0047405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine-5'-nucleotide nucleosidase activity
GO:0047405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Pyr5N activity
REACT:R-SSC-6784423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Sus scrofa)
REACT:R-GGA-202237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)
REACT:R-SSC-9645406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Sus scrofa)
REACT:R-SSC-9645524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose binds TIFA (Sus scrofa)
REACT:R-HSA-8944230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Homo sapiens)
REACT:R-XTR-159431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Xenopus tropicalis)
RHEA:71125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + 2 CO2 + 2 CoA + diphosphate + hispidin => (E)-caffeate + ATP + H(+) + 2 malonyl-CoA
REACT:R-MMU-3249392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Mus musculus)
RHEA:68339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine sulfonate + H2O <=> (R)-pantetheine sulfonate + phosphate
GO:0044594	skos:altLabel	"20alpha-hydroxysteroid dehydrogenase"
GO:0044594	skos:altLabel	"17beta-HSD"
GO:0044594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0044594	skos:prefLabel	"17beta-estradiol 17-dehydrogenase"
GO:0044594	skos:altLabel	"17beta-estradiol dehydrogenase"
GO:0044594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + NAD(+) = estrone + H(+) + NADH
GO:0044594	skos:altLabel	"17beta-hydroxysteroid dehydrogenase"
GO:0044594	skos:altLabel	"estrogen 17-oxidoreductase"
GO:0044594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"17beta-estradiol 17-dehydrogenase"
GO:0044594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + NADP(+) = estrone + H(+) + NADPH
REACT:R-BTA-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Bos taurus)
REACT:R-MMU-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Mus musculus)
REACT:R-CFA-6807052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBP isomerizes ZYMSTNL to LTHSOL (Canis familiaris)
RHEA:51090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:37145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA
RHEA:62333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ATP => adenosine 3'-diphosphate,5'-diphosphate + AMP
REACT:R-HSA-9690439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds LTC4,LTD4,LTE4 (Homo sapiens)
RHEA:40165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + 2 H(+) + NADPH => D-glyceraldehyde + H2O + NADP(+)
REACT:R-SCE-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Saccharomyces cerevisiae)
REACT:R-DRE-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Danio rerio)
RHEA:29394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O <=> diphosphate + GMP + H(+)
RHEA:62663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol <=> (2'R)-atrovenetin
RHEA:65231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol
RHEA:45239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]
REACT:R-CFA-201648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, Endofin, recruits R-Smad1/5/8 (Canis familiaris)
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epoxyalkane:CoM transferase activity
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epoxyalkyl:CoM transferase activity
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	EaCoMT activity
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epoxypropane:coenzyme M transferase activity
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epoxyalkane:2-mercaptoethanesulfonate transferase activity
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxypropyl-CoM lyase activity
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epoxyalkane:coenzyme M transferase activity
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epoxypropyl:CoM transferase activity
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme M-epoxyalkane ligase activity
GO:0050555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)
REACT:R-SSC-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Sus scrofa)
REACT:R-CFA-9691174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the ER membrane (Canis familiaris)
REACT:R-MMU-416929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PGF2a (Mus musculus)
REACT:R-RNO-9005995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the SIN3A co-repressor complex (Rattus norvegicus)
RHEA:28164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + GDP + H(+) => cytidine + GTP
REACT:R-DRE-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Danio rerio)
REACT:R-DME-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Drosophila melanogaster)
REACT:R-HSA-3781009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 (Homo sapiens)
REACT:R-DRE-212263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 trimethylates histone H3 at lysine-27 (Danio rerio)
RHEA:19375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + L-lysine + NADPH => H2O + L-saccharopine + NADP(+)
RHEA:58958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in RNA + S-adenosyl-L-methionine
RHEA:48922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate
RHEA:59545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose + O2 => H2O2 + N,N'-diacetylchitobiono-1,5-lactone
REACT:R-CFA-5362549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np traffics to the plasma membrane (Canis familiaris)
RHEA:59552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N',N'',N'''-tetraacetylchitotetraose + O2 = H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone
RHEA:38362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 <=> thiosulfate + ubiquinol-10
REACT:R-DME-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Drosophila melanogaster)
RHEA:35899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
RHEA:33587	skos:prefLabel	"UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase"
RHEA:33587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
RHEA:33587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase"
REACT:R-DDI-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Dictyostelium discoideum)
REACT:R-HSA-193650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR binds to NADE (Homo sapiens)
REACT:R-XTR-139855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X1-mediated entry of Ca++ from plasma (Xenopus tropicalis)
REACT:R-CFA-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Canis familiaris)
GO:0022828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylation-gated channel activity
REACT:R-MMU-2064417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-1 (TJP1) (Mus musculus)
REACT:R-BTA-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Bos taurus)
RHEA:54943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]
GO:0008198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferrous iron binding
REACT:R-GGA-140870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Gallus gallus)
REACT:R-BTA-3769397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOST binds LRP5/6 (Bos taurus)
REACT:R-RNO-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Rattus norvegicus)
REACT:R-XTR-8848339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA5 hydrolyzes TAG (Xenopus tropicalis)
REACT:R-XTR-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Xenopus tropicalis)
REACT:R-DRE-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Danio rerio)
GO:0000030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyltransferase activity
REACT:R-RNO-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Rattus norvegicus)
RHEA:23038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-dehydroinosine + 2 H2O => 2 inosine + O2
RHEA:17194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate
RHEA:57337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP
RHEA:53732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate = 2-hydroxy-7,8-dihydropteroate + diphosphate
GO:0038181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bile acid receptor activity
REACT:R-DRE-8983872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Danio rerio)
GO:0036478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDC activator activity
GO:0036478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa decarboxylase activator activity
REACT:R-DRE-888614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO2 dioxygenates L-Trp to NFK (Danio rerio)
REACT:R-SSC-5693609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53 at S15 (Sus scrofa)
GO:0008525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine transporter activity
GO:0008525	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylcholine transmembrane transporter activity
REACT:R-CEL-2064406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Caenorhabditis elegans)
RHEA:28282	skos:prefLabel	"(S)-beta-macrocarpene synthase"
RHEA:28282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-beta-macrocarpene synthase"
RHEA:28282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-bisabolene = (S)-beta-macrocarpene
RHEA:62044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)
GO:0052911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribosomal ribonucleate guanine 1-methyltransferase activity
GO:0052911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	rRNA(m(1)G)methylase activity
GO:0052911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	rlmA(I) methyltransferase activity
GO:0052911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity
GO:0052911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	23S rRNA m(1)G(745) methyltransferase activity
GO:0052911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribosomal RNA(m(1)G)-methylase activity
GO:0052911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23S rRNA (guanine(745)-N(1))-methyltransferase activity
REACT:R-BTA-8950522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1:p-STAT4 translocates to the nucleus (Bos taurus)
RHEA:70936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(in) => L-lysine(out)
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SPT
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serine-pyruvate aminotransferase, type 2B
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine:pyruvate aminotransferase activity
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine--pyruvate aminotransferase activity
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine--pyruvate transaminase"
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serine-pyruvate aminotransferase, type 2A
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-pyruvate transaminase activity
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxypyruvate:L-alanine transaminase activity
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + pyruvate = 3-hydroxypyruvate + L-alanine
GO:0004760	skos:altLabel	"serine--pyruvate aminotransferase"
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serine-pyruvate aminotransferase, type 1
GO:0004760	skos:prefLabel	"serine--pyruvate transaminase"
GO:0004760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-pyruvate aminotransferase activity
RHEA:20396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[citrate lyase ACP] + S-acetylphosphopantotheine <=> (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]
RHEA:71061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-leucine(in) => L-arginine(in) + L-leucine(out)
RHEA:45358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoate + sphing-4-enine => H2O + N-(11Z-eicosenoyl)-sphing-4-enine
REACT:R-MMU-5654402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
RHEA:33792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sucrose 6(F)-phosphate => beta-D-fructose + beta-D-glucose 6-phosphate
REACT:R-MMU-177942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EGF ligand (Mus musculus)
GO:0052706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:L-histidine alpha-N-methyltransferase activity
GO:0052706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase activity
GO:0052706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine N-methyltransferase activity
GO:0052706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine methyltransferase activity
GO:0052706	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histidine-alpha-N-methyltransferase activity
RHEA:51933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite => 2 Fe(II)-[cytochrome c3] + thiosulfate
REACT:R-BTA-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)
REACT:R-PFA-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Plasmodium falciparum)
REACT:R-RNO-1471338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 1, 4A and 103 bind CCR6 (Rattus norvegicus)
REACT:R-SSC-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Sus scrofa)
REACT:R-DRE-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Danio rerio)
RHEA:52876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-BTA-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Bos taurus)
REACT:R-GGA-8863472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAB2 binds LRP2 (Gallus gallus)
REACT:R-MMU-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Mus musculus)
REACT:R-DME-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Drosophila melanogaster)
REACT:R-HSA-3636919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)
REACT:R-BTA-5660665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 binds MALT (Bos taurus)
RHEA:57185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + methylglyoxal => S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]
RHEA:20133	skos:prefLabel	"aromatic 2-oxoacid reductase"
RHEA:20133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aromatic 2-oxoacid reductase"
RHEA:20133	skos:altLabel	"indolelactate dehydrogenase"
RHEA:20133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(indol-3-yl)lactate + NAD(+) = H(+) + indole-3-pyruvate + NADH
RHEA:20133	skos:altLabel	"indole-3-lactate dehydrogenase"
RHEA:20133	skos:altLabel	"(R)-aromatic lactate dehydrogenase"
RHEA:20133	skos:altLabel	"(R)-4-hydroxyphenyllactate dehydrogenase"
RHEA:10446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-laudanine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine
RHEA:65519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O <=> NH4(+) + pre-mycofactocin
REACT:R-SPO-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Schizosaccharomyces pombe)
RHEA:64357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O
RHEA:22567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-[ACP] + NADP(+) <=> a (2E)-enoyl-[ACP] + H(+) + NADPH
RHEA:43614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(341) in tmRNA
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol Delta(24(28))-methylene reductase activity
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C-24(28) sterol reductase activity
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol delta-24(28) reductase activity
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta24(24-1) sterol reductase activity
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D24(24-1)-sterol reductase activity
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol delta24(28)-methylene reductase activity
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol Delta(24(28))-reductase activity
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol delta24(28)-reductase activity
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ergosterol:NADP+ delta24(241)-oxidoreductase activity
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol delta-24(28) methylene reductase activity
GO:0000246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta24(241)-sterol reductase activity
REACT:R-GGA-4551683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOPORS with SUMO1 (Gallus gallus)
REACT:R-GGA-877198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates membrane pores that include pannexin-1 (Gallus gallus)
RHEA:33605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+) => H(+) + N-hexacosanoylsphinganine + NADPH + O2
REACT:R-DRE-420274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIP receptor binds gastric inhibitory peptide (Danio rerio)
RHEA:58695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV <=> FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal
RHEA:19851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose 2'-phosphate + H(+) + nicotinamide => H2O + NADP(+)
RHEA:55044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-tetradecadienoyl-CoA + H2O = (3E,5Z)-tetradecadienoate + CoA + H(+)
RHEA:55379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a quinol + O2 <=> 2 a quinone + 2 H2O
REACT:R-CFA-9026405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Canis familiaris)
REACT:R-XTR-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Xenopus tropicalis)
REACT:R-SSC-77304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Sus scrofa)
RHEA:52038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine + tuberonate => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate
REACT:R-DRE-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Danio rerio)
REACT:R-BTA-6788611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYKK phosphorylates 5HLYS (Bos taurus)
RHEA:71112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + S-methylmercury-L-cysteine(in) => L-phenylalanine(in) + S-methylmercury-L-cysteine(out)
RHEA:46405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DDI-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Dictyostelium discoideum)
REACT:R-DME-1504186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL recruits GSK3beta:AXIN1 to the receptor complex (Drosophila melanogaster)
RHEA:50374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphingoid base 1-phosphate(out) => an N-acylsphingoid base 1-phosphate(in)
REACT:R-RNO-5658424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Rattus norvegicus)
REACT:R-SSC-2130349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Generation of CLIP from lip10 (Sus scrofa)
REACT:R-GGA-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Gallus gallus)
RHEA:39801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+)
REACT:R-DRE-6787820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds CSF1R (Danio rerio)
REACT:R-CEL-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
REACT:R-XTR-209055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A dephosphorylates nuclear SMAD2/3 (Xenopus tropicalis)
RHEA:42111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone
REACT:R-XTR-192434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of diacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)
REACT:R-HSA-5357776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
REACT:R-SSC-1236955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Movement of clathrin coated vesicles into early endosome (Sus scrofa)
RHEA:62296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) = (+)-malbrancheamide + 2 FADH2
REACT:R-HSA-5096532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GALNT12 does not transfer GalNAc to mucins (Homo sapiens)
REACT:R-SPO-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Schizosaccharomyces pombe)
REACT:R-CEL-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Caenorhabditis elegans)
REACT:R-GGA-2562564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 processing within TLR4 complex (Gallus gallus)
RHEA:50666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose
REACT:R-DDI-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Dictyostelium discoideum)
REACT:R-GGA-9632918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Gallus gallus)
RHEA:19323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + N-methylaniline => N,N-dimethylaniline N-oxide
REACT:R-RNO-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Rattus norvegicus)
REACT:R-DDI-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
REACT:R-DRE-2426569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and IREM2 (Danio rerio)
REACT:R-RNO-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Rattus norvegicus)
REACT:R-HSA-9021072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC7, ZDHHC21 palmitoylate ESR1 (Homo sapiens)
RHEA:26486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-phospho-L-serine + sulfite = L-cysteate + phosphate
RHEA:26486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteate synthase"
RHEA:26486	skos:prefLabel	"cysteate synthase"
RHEA:15480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 5beta-scymnol <=> 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:24372	skos:prefLabel	"N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase"
RHEA:24372	skos:altLabel	"alpha-N-acetylglucosaminyl phosphodiesterase"
RHEA:24372	skos:altLabel	"lysosomal alpha-N-acetylglucosaminidase"
RHEA:24372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase"
RHEA:24372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] = H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine
GO:0008029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentraxin receptor activity
GO:0008029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentaxin receptor
RHEA:27734	skos:altLabel	"polymyxin resistance protein PmrJ"
RHEA:27734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate
RHEA:27734	skos:prefLabel	"4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase"
RHEA:27734	skos:altLabel	"undecaprenyl-phosphate-alpha-L-Ara4FN deformylase"
RHEA:27734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase"
REACT:R-MMU-77327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Mus musculus)
REACT:R-SSC-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Sus scrofa)
REACT:R-XTR-193369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Xenopus tropicalis)
REACT:R-HSA-9660192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR agonists bind VDR (Homo sapiens)
RHEA:70631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-SSC-3149539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Sus scrofa)
REACT:R-RNO-5362441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Rattus norvegicus)
REACT:R-HSA-9694401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E protein gets palmitoylated (Homo sapiens)
RHEA:23048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate
RHEA:42163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O
REACT:R-DRE-159574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Danio rerio)
REACT:R-SSC-6781814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 deubiquitinates RNF123 (Sus scrofa)
RHEA:19490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide => 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)
REACT:R-CFA-5661121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Canis familiaris)
REACT:R-SPO-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Schizosaccharomyces pombe)
REACT:R-DME-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
RHEA:61417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol => cis-trans-nepetalactol
RHEA:34616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + O2 => H(+) + hydrogencarbonate + methylphosphonate
RHEA:65556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside GalGb4Cer + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc
REACT:R-SSC-417842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 receptor can bind to LPA (Sus scrofa)
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPNH dehydrogenase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2 diaphorase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	old yellow enzyme
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPNH-diaphorase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OYE
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:(acceptor) oxidoreductase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dehydrogenase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triphosphopyridine nucleotide diaphorase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triphosphopyridine diaphorase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH dehydrogenase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2-dehydrogenase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH diaphorase activity
GO:0003959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:acceptor oxidoreductase activity
GO:0032523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	silicon efflux transmembrane transporter activity
GO:0032523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	silicon efflux transporter activity
RHEA:69179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] <=> 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]
RHEA:64449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine
RHEA:53932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-9626848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Rattus norvegicus)
RHEA:23633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH
GO:0033938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-alpha-L-fucosidase activity
GO:0033938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity
REACT:R-MMU-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Mus musculus)
RHEA:60154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + L-glutamyl-[protein] => gamma-L-glutamyl-L-glutamyl-[protein] + H2O
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	furanocoumarin 5-methyltransferase activity
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bergaptol O-methyltransferase activity
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BMT activity
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:bergaptol O-methyltransferase activity
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bergaptol methyltransferase activity
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	furanocoumarin 5-O-methyltransferase activity
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:bergaptolO-methyltransferase activity
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bergaptol 5-O-methyltransferase activity
GO:0030752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyfuranocoumarin 5-O-methyltransferase activity
REACT:R-SSC-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Sus scrofa)
REACT:R-SSC-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Sus scrofa)
REACT:R-CFA-416320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR1-containing  AMPA receptors (Canis familiaris)
RHEA:61850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-glucoside + H(+) + UDP => cholesterol + UDP-alpha-D-glucose
EC:2.4.1.199	skos:prefLabel	"beta-mannosylphosphodecaprenol--mannooligosaccharide 6-mannosyltransferase"
EC:2.4.1.199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-mannosylphosphodecaprenol--mannooligosaccharide 6-mannosyltransferase"
GO:0050438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-ethylmalate synthase"
GO:0050438	skos:altLabel	"2-ethylmalate-3-hydroxybutanedioate synthase"
GO:0050438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ethylmalate-3-hydroxybutanedioate synthase activity
GO:0050438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propylmalate synthase activity
GO:0050438	skos:prefLabel	"2-ethylmalate synthase"
GO:0050438	skos:altLabel	"propylmalate synthase"
GO:0050438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity
GO:0050438	skos:altLabel	"(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating)"
GO:0050438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propylmalic synthase activity
GO:0050438	skos:altLabel	"propylmalic synthase"
GO:0050438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethylmalate synthase activity
GO:0050438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
GO:0050438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+)
RHEA:48205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:34241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopentanedioate => L-glutamate
REACT:R-GGA-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Gallus gallus)
RHEA:70198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + deamido-NAD(+) <=> ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate
REACT:R-GGA-216082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaXbeta2 with fibrin (Gallus gallus)
REACT:R-HSA-190265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds to FGF (Homo sapiens)
REACT:R-DDI-83790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Dictyostelium discoideum)
REACT:R-SSC-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Sus scrofa)
REACT:R-DRE-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Danio rerio)
RHEA:58411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + undecan-1-ol <=> H(+) + NADPH + undecanal
RHEA:56762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-182969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)
REACT:R-BTA-199579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR2DL4 interacting with HLA-G (Bos taurus)
RHEA:15941	skos:altLabel	"N-acetylornithinase"
RHEA:15941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylornithine deacetylase"
RHEA:15941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-acetyl-L-ornithine = acetate + L-ornithine
RHEA:15941	skos:prefLabel	"acetylornithine deacetylase"
RHEA:15941	skos:altLabel	"acetylornithinase"
RHEA:59139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + D-ornithine <=> AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine
REACT:R-SSC-434836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk/Lck phosphorylate LAT (Sus scrofa)
REACT:R-BTA-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Bos taurus)
REACT:R-DRE-77299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Danio rerio)
REACT:R-DRE-75883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHRS7B reduces GO3P to HXDG3P (Danio rerio)
GO:0043908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ser(Gly)-tRNAAla hydrolase activity
GO:0043908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ser(Gly)-tRNA(Ala) hydrolase activity
REACT:R-MMU-158419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Mus musculus)
RHEA:20556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-methylmalonyl-CoA <=> (S)-methylmalonyl-CoA
RHEA:27909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + H(+) + NADPH
RHEA:37260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + H2O + NAD(+) => 2-oxobutanoate + H(+) + NADH + NH4(+)
REACT:R-SSC-877281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 binds p-STAT1 dimer (Sus scrofa)
REACT:R-CEL-196417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of desmosterol to cholesterol (Caenorhabditis elegans)
GO:0070043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 (Homo sapiens)
GO:0070043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (guanine-N7-)-methyltransferase activity
GO:0034929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxypyrene 7,8-monooxygenase activity
REACT:R-MMU-69562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Mus musculus)
RHEA:57548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] = [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Dictyostelium discoideum)
RHEA:11197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide => alpha-ribazole 5'-phosphate + H(+) + nicotinate
RHEA:57623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]
RHEA:29775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate + ATP = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)
REACT:R-HSA-8937856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-YAP1 translocates to the nucleus (Homo sapiens)
REACT:R-DRE-8852013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL8 binds resting T cell surface (Danio rerio)
REACT:R-DRE-8875591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK7 activates RAC1 (Danio rerio)
RHEA:10553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + O2 => 2-dehydro-D-glucose + H2O2
REACT:R-BTA-5662660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopachrome is transformed to DHICA by DCT (Bos taurus)
RHEA:41115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine
REACT:R-DRE-8942208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOXE3 isomerises 12R-HpETE to HXA3 (Danio rerio)
REACT:R-MMU-8876615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB13 GEFs exchange GTP for GDP on RAB13 (Mus musculus)
GO:0080032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonic acid methyl ester esterase activity
GO:0080032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEJA esterase activity
GO:0080032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl jasmonate esterase activity
GO:0080032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl JA esterase activity
GO:0031177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopantetheine binding
REACT:R-DRE-193099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)
REACT:R-GGA-8982165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Gallus gallus)
GO:0034903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endosulfan ether monooxygenase activity
RHEA:54271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate
REACT:R-BTA-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Bos taurus)
REACT:R-DRE-5694082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XK:KEL:Zn2+ cleaves EDN3 (Danio rerio)
REACT:R-MMU-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Mus musculus)
RHEA:62523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in rRNA + S-adenosyl-L-methionine <=> an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:23618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-santonin + H(+) + NADPH => 1,2-dihydro-alpha-santonin + NADP(+)
RHEA:44979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + propanoyl-CoA <=> CoA + O-propanoyl-(R)-carnitine
RHEA:12262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + NADPH => ATP + NADH
REACT:R-GGA-432121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL binds to LRP8 (Gallus gallus)
REACT:R-GGA-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Gallus gallus)
REACT:R-CEL-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Caenorhabditis elegans)
RHEA:26157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose + NADP(+) => D-glucosone + H(+) + NADPH
GO:1905394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retromer complex binding
REACT:R-DRE-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Danio rerio)
REACT:R-DME-8956140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 and UBD bind NUB1 and the 26S proteasome (Drosophila melanogaster)
REACT:R-GGA-2731122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2 & 4 bind VTN (Gallus gallus)
REACT:R-GGA-389759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP-1 or SHP-2 with phospho PD-1 (Gallus gallus)
RHEA:27974	skos:altLabel	"7-carboxy-7-carbaguanine synthase"
RHEA:27974	skos:prefLabel	"7-carboxy-7-deazaguanine synthase"
RHEA:27974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)
RHEA:27974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-carboxy-7-deazaguanine synthase"
REACT:R-BTA-352107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Bos taurus)
REACT:R-GGA-158893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Gallus gallus)
RHEA:65343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-threonyl-[protein] <=> CoA + O-acetyl-L-threonyl-[protein]
EC:7.5.2.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type lipopolysaccharide transporter"
EC:7.5.2.5	skos:altLabel	"lipopolysaccharide-transporting ATPase"
EC:7.5.2.5	skos:altLabel	"lipopolysaccharide transport system"
EC:7.5.2.5	skos:prefLabel	"ABC-type lipopolysaccharide transporter"
RHEA:71148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhispidin + O2 => 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one
REACT:R-RNO-400143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fatty acid ligands activate PPARA (Rattus norvegicus)
RHEA:19910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate
RHEA:56001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)
REACT:R-MMU-5218826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)
RHEA:34065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-alpha-D-glucose
REACT:R-SCE-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Saccharomyces cerevisiae)
REACT:R-XTR-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Xenopus tropicalis)
REACT:R-DDI-3000449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Dictyostelium discoideum)
REACT:R-SCE-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Saccharomyces cerevisiae)
RHEA:46293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate
GO:0099534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering
GO:0099534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium ion binding involved in regulation of presynaptic cytosolic calcium levels
GO:0099534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	presynaptic calcium ion buffering
GO:0099534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
REACT:R-DDI-9027624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DHA to 7-HDHA (Dictyostelium discoideum)
RHEA:32913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphocholine(in) => sn-glycerol 3-phosphocholine(out)
RHEA:45193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
RHEA:31956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Homo sapiens)
RHEA:31808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => alpha-guaiene + diphosphate
RHEA:67039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 <=> (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate
REACT:R-RNO-76500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBXAS1 isomerises PGH2 to TXA2 (Rattus norvegicus)
REACT:R-HSA-9646295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p14ARF mutant does not translocate to the nucleus (Homo sapiens)
RHEA:22478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+)
RHEA:60430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + L-aspartate => (indol-3-yl)acetyl-L-aspartate + H2O
RHEA:65973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a peptide antigen(in) + ATP + H2O => a peptide antigen(out) + ADP + H(+) + phosphate
REACT:R-HSA-109339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation (Homo sapiens)
RHEA:58478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + CoA => an acyl-CoA + sn-glycerol 3-phosphocholine
REACT:R-SSC-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Sus scrofa)
REACT:R-XTR-8865265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds MYC and KDM5B (Xenopus tropicalis)
GO:0043748	skos:altLabel	"o-succinylbenzoic acid synthase"
GO:0043748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"o-succinylbenzoate synthase"
GO:0043748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-succinylbenzoate synthase activity
GO:0043748	skos:prefLabel	"o-succinylbenzoate synthase"
GO:0043748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O
GO:0043748	skos:altLabel	"OSBS"
GO:0043748	skos:altLabel	"OSB synthase"
GO:0043748	skos:altLabel	"2-succinylbenzoate synthase"
EC:5.1.3.-	skos:prefLabel	"Acting on carbohydrates and derivatives"
EC:5.1.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on carbohydrates and derivatives"
REACT:R-CFA-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Canis familiaris)
RHEA:38288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalate + succinyl-CoA => (3S)-citramalyl-CoA + succinate
GO:0061658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	URM1 conjugating enzyme activity
GO:0061658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
RHEA:23381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP
REACT:R-SSC-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Sus scrofa)
RHEA:50513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]
RHEA:16887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin IXalpha + bilirubin-bisglucuronoside => 2 bilirubin-glucuronoside
REACT:R-CEL-2028555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Caenorhabditis elegans)
RHEA:31854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> parkeol
RHEA:20138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetylbaccatin III + acetyl-CoA => baccatin III + CoA
GO:0032577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine:cardiolipin O-linoleoyltransferase activity
GO:0032577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine:cardiolipin linoleoyltransferase
REACT:R-GGA-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Gallus gallus)
RHEA:52385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + O-phospho-L-serine => H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate
REACT:R-BTA-6809325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)
REACT:R-DME-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Drosophila melanogaster)
RHEA:67900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate + succinyl-CoA = glutaryl-CoA + succinate
REACT:R-XTR-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Xenopus tropicalis)
RHEA:52631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-fatty-acyl-L-alpha-amino acid + H2O <=> a fatty acid + an L-alpha-amino acid
REACT:R-DRE-8853755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Danio rerio)
RHEA:44633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dihydroxyphenyl)acetyl-CoA + O2 => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)
REACT:R-PFA-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Plasmodium falciparum)
RHEA:57436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guaethol + O2 + reduced [NADH--hemoprotein reductase] = acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
RHEA:60289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine
GO:0140104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular carrier activity
RHEA:47003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Bos taurus)
REACT:R-BTA-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Bos taurus)
RHEA:18512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + NADH <=> 2 H2O + NAD(+)
RHEA:28255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hex-3-en-1-ol + acetyl-CoA => (3Z)-hex-3-en-1-yl acetate + CoA
REACT:R-CFA-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Canis familiaris)
RHEA:34609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine
REACT:R-MMU-8855237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Mus musculus)
RHEA:51598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0030622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U4atac snRNA binding
RHEA:48877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-glucosamine
REACT:R-CEL-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Caenorhabditis elegans)
REACT:R-SSC-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Sus scrofa)
RHEA:19246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-phenylhydroxylamine => 2-aminophenol
RHEA:41360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-MMU-4085087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Mus musculus)
GO:0102277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity
REACT:R-MMU-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)
RHEA:62878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + semiviriditoxin => AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate
REACT:R-PFA-450971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Plasmodium falciparum)
REACT:R-SCE-6809015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Saccharomyces cerevisiae)
REACT:R-CFA-450580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 (hnRNP D0) is ubiquitinylated (Canis familiaris)
REACT:R-BTA-9014295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)
RHEA:24670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine
REACT:R-DME-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Drosophila melanogaster)
RHEA:55507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-hydroxy-L-arginine + NADP(+) => H(+) + L-arginine + NADPH + O2
REACT:R-RNO-445069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-EGFR trans-heterodimerization (Rattus norvegicus)
REACT:R-HSA-111804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
RHEA:20955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:39922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(alk-1-enyl)-sn-glycerol + phosphate
RHEA:14837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyoxylate oxidase"
RHEA:14837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate
RHEA:14837	skos:prefLabel	"glyoxylate oxidase"
REACT:R-MMU-1638104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Mus musculus)
GO:0047635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine-oxo-acid transaminase activity
GO:0047635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-keto acid aminotransferase activity
GO:0047635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine-alpha-keto acid aminotransferase activity
GO:0047635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine:2-oxo-acid aminotransferase activity
GO:0047635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-oxo acid aminotransferase activity
GO:0047635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine--oxo-acid aminotransferase activity
GO:0047635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine-oxo-acid aminotransferase activity
GO:0047635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine-alanine transaminase activity
REACT:R-MMU-1606564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Mus musculus)
REACT:R-XTR-2161999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Xenopus tropicalis)
RHEA:69751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylmalonyl-CoA + H(+) + O2 = (E)-cinnamoyl-CoA + CO2 + H2O2
RHEA:52478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-O-(beta-D-glucuronate) + H(+) + UDP => estrone + UDP-alpha-D-glucuronate
REACT:R-RNO-8953418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 complex binds E2F6.com-1 core (Rattus norvegicus)
RHEA:33610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + ATP + CoA <=> (9Z)-octadecenoyl-CoA + AMP + diphosphate
RHEA:38461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA
RHEA:58342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O
GO:0034568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoproturon dimethylaminedehydrogenase activity
REACT:R-HSA-209738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 binds GC (Homo sapiens)
RHEA:48659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[protein] + serotonin => 5-serotonyl-L-glutamyl-[protein] + NH4(+)
REACT:R-RNO-204169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP dephosphorylates p-lipo-PDH (Rattus norvegicus)
REACT:R-CFA-5688289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Canis familiaris)
REACT:R-MMU-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Mus musculus)
REACT:R-CFA-110251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of hypoxanthine by MPG glycosylase (Canis familiaris)
RHEA:52635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP
RHEA:24804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-isoleucine <=> (S)-3-methyl-2-oxopentanoate + L-glutamate
RHEA:37730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-CFA-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Canis familiaris)
REACT:R-GGA-373145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + H2O <=> malate (Gallus gallus)
RHEA:57539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate <=> a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)
REACT:R-CFA-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Canis familiaris)
REACT:R-RNO-202702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD177 binds PECAM-1 (Rattus norvegicus)
REACT:R-MMU-8848087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAP2 recruits STAT3 to PTK6 (Mus musculus)
RHEA:49193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
REACT:R-GGA-507719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62:MEKK3 binds to TRAF6 (Gallus gallus)
RHEA:28946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(in) <=> glycine betaine(out)
RHEA:13838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => 4,5-dihydroxyphthalate + H(+) + NADH
REACT:R-SSC-416985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to synapse (Sus scrofa)
RHEA:25999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine + O2 <=> H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine
REACT:R-CFA-8870732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSGs bind proteoglycans and TGF-beta1 (Canis familiaris)
GO:0042286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate
GO:0042286	skos:prefLabel	"glutamate-1-semialdehyde 2,1-aminomutase"
GO:0042286	skos:altLabel	"glutamate-1-semialdehyde aminotransferase"
GO:0042286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate-1-semialdehyde 2,1-aminomutase"
GO:0042286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate-1-semialdehyde aminotransferase activity
GO:0042286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-1-semialdehyde 2,1-aminomutase activity
GO:0042286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity
REACT:R-HSA-74748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De-phosphorylation of p-Y427-SHC1 (Homo sapiens)
RHEA:41631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + H2O <=> cyclooctat-9-en-7-ol + diphosphate
REACT:R-RNO-8851679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR183 binds 7alpha,25-dihydroxycholesterol (Rattus norvegicus)
REACT:R-XTR-8877902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated AR binds RUNX2 (Xenopus tropicalis)
REACT:R-DRE-389523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTLA interacts with HVEM (Danio rerio)
RHEA:29102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 5 H(+)(in) + NADH <=> a menaquinol + 4 H(+)(out) + NAD(+)
REACT:R-PFA-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Plasmodium falciparum)
RHEA:60920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 = a cytidine in mRNA + CO2 + formaldehyde + succinate
RHEA:52322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin => O2 + reduced [NADPH--hemoprotein reductase] + tryptamine
EC:2.1.1.110	skos:altLabel	"S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase"
EC:2.1.1.110	skos:altLabel	"sterigmatocystin methyltransferase"
EC:2.1.1.110	skos:prefLabel	"sterigmatocystin 8-O-methyltransferase"
EC:2.1.1.110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sterigmatocystin 8-O-methyltransferase"
EC:2.1.1.110	skos:altLabel	"sterigmatocystin 7-O-methyltransferase"
EC:2.1.1.110	skos:altLabel	"O-methyltransferase II"
RHEA:66054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-tryptophan => indole-3-pyruvate + L-kynurenine
REACT:R-DME-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Drosophila melanogaster)
REACT:R-XTR-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Xenopus tropicalis)
RHEA:62501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-arginyl-AMP => AMP + H(+) + L-arginyl-[peptidyl-carrier protein]
RHEA:65637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-(4E,8E)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine
GO:0003720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomerase activity
REACT:R-MMU-6805035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds STK11 and NUAK1 (Mus musculus)
REACT:R-GGA-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Gallus gallus)
RHEA:31909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-coclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-norcoclaurine + S-adenosyl-L-methionine
RHEA:58218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + serpentine => A + dihydroserpentine
REACT:R-CFA-8869606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NAR to yield NAMN (Canis familiaris)
REACT:R-MMU-983703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-SYK phosphorylates BLNK (SLP65) (Mus musculus)
REACT:R-BTA-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Bos taurus)
REACT:R-CFA-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Canis familiaris)
RHEA:24099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoorientin + S-adenosyl-L-methionine <=> H(+) + isoscoparin + S-adenosyl-L-homocysteine
REACT:R-SSC-9658445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Sus scrofa)
REACT:R-XTR-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Xenopus tropicalis)
REACT:R-HSA-2247512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Homo sapiens)
GO:0061133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endopeptidase activator activity
RHEA:45143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O <=> CO2 + L-glutamyl-[protein] + O2 + phylloquinol
REACT:R-HSA-9640060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNIP3 binds NPAS4 gene promoter (Homo sapiens)
REACT:R-BTA-5661517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC comlex binds OTULIN (Bos taurus)
REACT:R-HSA-392263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR2 (Homo sapiens)
REACT:R-SSC-9610750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Sus scrofa)
REACT:R-XTR-8987043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22RA1 binds JAK1 (Xenopus tropicalis)
REACT:R-SPO-5651654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)
REACT:R-SCE-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)
REACT:R-HSA-936942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)
RHEA:13327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine
RHEA:13962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mg(2+) + protoporphyrin IX => ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate
RHEA:32576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (1R,5R)-alpha-pinene + diphosphate
REACT:R-DME-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Drosophila melanogaster)
GO:0016084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myostimulatory hormone activity
REACT:R-MMU-2408524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Mus musculus)
REACT:R-MMU-374758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Somatostatin receptors bind somatostatin and cortistatin (Mus musculus)
RHEA:39278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH <=> (15Z)-tetracosenoyl-CoA + NADP(+)
RHEA:36361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a plastoquinol + O2 => 2 a plastoquinone + 2 H2O + 4 hnu
REACT:R-CFA-209868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
REACT:R-GGA-8964271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in PIP3:BTK:G beta-gamma complex is activated (Gallus gallus)
RHEA:12558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + H(+) => 6-phospho-D-glucono-1,5-lactone + H2O
REACT:R-RNO-9018594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds LBR (Rattus norvegicus)
REACT:R-GGA-5654159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds PLCG1 (Gallus gallus)
REACT:R-SSC-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Sus scrofa)
REACT:R-DME-9611721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1-agonists bind ADRB1 (Drosophila melanogaster)
RHEA:30425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-DME-201425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Drosophila melanogaster)
RHEA:57743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated meromycolyl-[ACP] + NAD(+) <=> a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH
REACT:R-SCE-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Saccharomyces cerevisiae)
REACT:R-DRE-1855219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)
REACT:R-RNO-5229194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Depolymerization of lamin filaments after PKC-mediated phosphorylation (Rattus norvegicus)
REACT:R-DRE-4090390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates AR with SUMO1 (Danio rerio)
RHEA:29893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-histidine(in) + phosphate => ATP + H2O + L-histidine(out)
RHEA:43070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-9733203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4 (Homo sapiens)
REACT:R-XTR-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Xenopus tropicalis)
GO:0038198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	auxin receptor activity
RHEA:13202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-arginine => guanidinoacetate + L-ornithine
RHEA:44371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cr(6+) + 2 NADPH + O2 <=> Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide
REACT:R-MMU-1678660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan sulfate chain(3) (Mus musculus)
RHEA:56885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)
RHEA:30868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-acetaldehyde + NAD(+) => (indol-3-yl)acetate + 2 H(+) + NADH
REACT:R-SPO-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Schizosaccharomyces pombe)
RHEA:50491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]
REACT:R-RNO-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Rattus norvegicus)
REACT:R-HSA-167235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
REACT:R-MMU-1971482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Mus musculus)
REACT:R-SSC-5218806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN autophosphorylates (Sus scrofa)
RHEA:70513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:48975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphite(out) <=> ADP + H(+) + phosphate + phosphite(in)
RHEA:24055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + reduced [electron-transfer flavoprotein] <=> a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-SSC-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
REACT:R-HSA-9758674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)
REACT:R-HSA-354124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pPTK2 by SRC (Homo sapiens)
REACT:R-CFA-9018859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Canis familiaris)
REACT:R-SSC-4088218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetrastatin binds integrin alphaVbeta3 (Sus scrofa)
RHEA:50902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O
REACT:R-CFA-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)
REACT:R-GGA-9017817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-secretase cleaves YBX1:NOTCH3 (Gallus gallus)
RHEA:56765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 => 12-epi-fischerindole G + CO2 + H2O + succinate
REACT:R-CFA-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Canis familiaris)
REACT:R-BTA-444202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR1 binds free fatty acids (Bos taurus)
REACT:R-DME-9603986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 chains to form LeA (Drosophila melanogaster)
REACT:R-GGA-8854759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D14 binds RAB11 and ULK1 (Gallus gallus)
RHEA:28909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)propanoate(out) + H(+)(out) => 3-(3-hydroxyphenyl)propanoate(in) + H(+)(in)
GO:0052665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA uracil-2'-O-methyltransferase activity
GO:0052665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (uracil-2'-O-)-methyltransferase activity
GO:0052665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA (uracil 2')-methyltransferase activity
GO:0052665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA uracil 2'-methyltransferase activity
GO:0052665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA uracil-2'-O-methyltransferase activity
GO:0052665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (uracil-2'-O-)-methyltransferase activity
GO:0052665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate uracil 2'-methyltransferase activity
REACT:R-CFA-70859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Canis familiaris)
RHEA:20719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + S-adenosyl-L-homocysteine <=> NH4(+) + S-inosyl-L-homocysteine
RHEA:41365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:37094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA
REACT:R-CFA-203973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle budding (Canis familiaris)
RHEA:66602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dopamine quinone + 2 H2O => 2 dopamine + O2
REACT:R-HSA-8949649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)
REACT:R-GGA-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Gallus gallus)
REACT:R-SCE-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Saccharomyces cerevisiae)
EC:4.2.2.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannuronate-specific alginate lyase"
EC:4.2.2.3	skos:altLabel	"alginate lyase I"
EC:4.2.2.3	skos:altLabel	"poly(beta-D-mannuronate) lyase"
EC:4.2.2.3	skos:altLabel	"poly(mana) alginate lyase"
EC:4.2.2.3	skos:prefLabel	"mannuronate-specific alginate lyase"
RHEA:61474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-hexadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + hexadecanoyl-CoA
RHEA:19961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside
RHEA:19961	skos:prefLabel	"nucleoside phosphotransferase"
RHEA:19961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside phosphotransferase"
REACT:R-SSC-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Sus scrofa)
REACT:R-XTR-2046298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to a branch of keratan (Xenopus tropicalis)
REACT:R-XTR-3341397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)
REACT:R-HSA-1225894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL (Homo sapiens)
REACT:R-DRE-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Danio rerio)
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrolipoyllysine-residue acetyltransferase activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoylacetyltransferase activity
GO:0004742	skos:altLabel	"dihydrolipoic transacetylase"
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoyl acetyltransferase activity
GO:0004742	skos:altLabel	"lipoic acid acetyltransferase"
GO:0004742	skos:altLabel	"lipoic transacetylase"
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrolipoyllysine-residue acetyltransferase"
GO:0004742	skos:altLabel	"lipoate acetyltransferase"
GO:0004742	skos:altLabel	"lipoate transacetylase"
GO:0004742	skos:altLabel	"lipoylacetyltransferase"
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoate transacetylase activity
GO:0004742	skos:altLabel	"transacetylase X"
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoic acid acetyltransferase activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoic acetyltransferase activity
GO:0004742	skos:altLabel	"dihydrolipoamide S-acetyltransferase"
GO:0004742	skos:prefLabel	"dihydrolipoyllysine-residue acetyltransferase"
GO:0004742	skos:altLabel	"dihydrolipoyl acetyltransferase"
GO:0004742	skos:altLabel	"thioltransacetylase A"
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thioltransacetylase A activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:dihydrolipoamide S-acetyltransferase activity
GO:0004742	skos:altLabel	"lipoic acetyltransferase"
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transacetylase X activity
GO:0004742	skos:altLabel	"dihydrolipoate acetyltransferase"
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoic transacetylase activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrolipoamide S-acetyltransferase activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoic transacetylase activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoate acetyltransferase activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoamide S-acyltransferase activity
GO:0004742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrolipoate acetyltransferase activity
GO:0004742	skos:altLabel	"acetyl-CoA:dihydrolipoamide S-acetyltransferase"
REACT:R-MMU-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Mus musculus)
REACT:R-DRE-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Danio rerio)
REACT:R-CFA-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Canis familiaris)
REACT:R-GGA-187586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate (Gallus gallus)
REACT:R-HSA-418858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoGTPase GEF's recruited to DCC (Homo sapiens)
REACT:R-SCE-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Saccharomyces cerevisiae)
RHEA:32653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin B + H(+) + S-adenosyl-L-homocysteine => erythromycin D + S-adenosyl-L-methionine
REACT:R-MMU-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Mus musculus)
GO:0031543	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	prolyl hydroxylase activity
GO:0031543	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	proline hydroxylase activity
GO:0031543	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	prolyl 4-hydroxylase activity
GO:0031543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-proline dioxygenase activity
GO:0031543	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	proline,2-oxoglutarate 4-dioxygenase activity
REACT:R-HSA-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
EC:2.7.1.147	skos:altLabel	"ADP-dependent glucokinase"
EC:2.7.1.147	skos:altLabel	"ADP-specific glucokinase"
EC:2.7.1.147	skos:prefLabel	"ADP-specific glucose/glucosamine kinase"
EC:2.7.1.147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-specific glucose/glucosamine kinase"
GO:1990929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfoquinovosidase activity
REACT:R-RNO-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Rattus norvegicus)
RHEA:20056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + ribitol <=> D-ribulose + H(+) + NADH
REACT:R-SSC-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Sus scrofa)
GO:0047177	skos:prefLabel	"glycerophospholipid arachidonoyl-transferase (CoA-independent)"
GO:0047177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerophospholipid arachidonoyl-transferase (CoA-independent)"
GO:0047177	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)
GO:0047177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophospholipid arachidonoyl-transferase (CoA-independent) activity
GO:0047177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine
GO:0047177	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)
RHEA:38005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate
REACT:R-RNO-210289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-DAP12 (Rattus norvegicus)
REACT:R-BTA-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Bos taurus)
RHEA:49570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3,4-epoxy-3-methylbut-1-ene + glutathione => 2-glutathionyl-2-methylbut-3-en-1-ol
REACT:R-GGA-9700168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates IRS1 (Gallus gallus)
REACT:R-BTA-6785342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Bos taurus)
REACT:R-DDI-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Dictyostelium discoideum)
REACT:R-GGA-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Gallus gallus)
RHEA:71547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphomethyl-dUMP in DNA + glycine = 5-N(alpha)-glycyl-dTMP in DNA + phosphate
RHEA:16303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + H(+) + nicotinamide => H2O + NAD(+)
REACT:R-DME-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Drosophila melanogaster)
REACT:R-BTA-3238999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Bos taurus)
REACT:R-HSA-9009362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades PolyUb-RUNX2 (Homo sapiens)
REACT:R-XTR-419351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF receptor binds platelet activating factor (Xenopus tropicalis)
RHEA:72612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-lysine(out) => H(+)(in) + L-alanyl-L-lysine(in)
RHEA:44463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine
RHEA:37076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
RHEA:21443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 <=> a long-chain alkane + formate + H2O + 2 NADP(+)
REACT:R-CFA-870449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 monoubiquitinates SMAD4 (Canis familiaris)
REACT:R-SSC-419843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCR (Sus scrofa)
REACT:R-CEL-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Caenorhabditis elegans)
REACT:R-DRE-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Danio rerio)
RHEA:30189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + orotate => (S)-dihydroorotate + a quinone
REACT:R-XTR-390909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds hist (Xenopus tropicalis)
REACT:R-DME-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Drosophila melanogaster)
RHEA:22780	skos:altLabel	"13-lipoxidase"
RHEA:22780	skos:altLabel	"lipoperoxidase"
RHEA:22780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
RHEA:22780	skos:altLabel	"lipoxidase"
RHEA:22780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linoleate 13S-lipoxygenase"
RHEA:22780	skos:altLabel	"13-lipoperoxidase"
RHEA:22780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
RHEA:22780	skos:altLabel	"carotene oxidase"
RHEA:22780	skos:prefLabel	"linoleate 13S-lipoxygenase"
RHEA:17609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine
RHEA:17609	skos:prefLabel	"serine-type anaerobic sulfatase-maturating enzyme"
RHEA:17609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine-type anaerobic sulfatase-maturating enzyme"
RHEA:16763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+) => chlorohydroquinone + O2
RHEA:26208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + H(+) + NADPH + O2 <=> 4-nitrocatechol + H2O + NADP(+)
REACT:R-GGA-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Gallus gallus)
RHEA:45765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate 4-semialdehyde + NAD(+) => 2 H(+) + L-aspartate + NADH
RHEA:19086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
REACT:R-HSA-9623341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S133 CREB1 dimer binds the CCND1 promoter (Homo sapiens)
RHEA:52147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphonopyruvate + acetyl-CoA + H2O <=> (R)-2-(phosphonomethyl)malate + CoA + H(+)
RHEA:26449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + CoA + NADP(+) <=> H(+) + malonyl-CoA + NADPH
REACT:R-PFA-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Plasmodium falciparum)
REACT:R-SSC-9630923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B inhibitor binds NF-kappa-B complex (Sus scrofa)
REACT:R-GGA-373061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR3, 4 and 5 bind CCL5 ligand (Gallus gallus)
REACT:R-BTA-888577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GABA by GAD2 (Bos taurus)
RHEA:46367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-BTA-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Bos taurus)
RHEA:44567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-decaprenyl diphosphate <=> 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate
RHEA:56337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
GO:0019706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-cysteine S-palmitoyltransferase activity
GO:0019706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Homo sapiens)
GO:0019706	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-cysteine S-palmitoleyltransferase activity
RHEA:51856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) = (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
GO:0008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc binding
GO:0008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zn binding
GO:0008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc ion binding
REACT:R-BTA-8876283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Bos taurus)
REACT:R-DRE-8875451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates CBL (Danio rerio)
REACT:R-GGA-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Gallus gallus)
RHEA:64049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + sphinganine => CoA + H(+) + N-(13Z-docosenoyl)-sphinganine
RHEA:26441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + NADP(+) <=> 3-oxopropanoate + H(+) + NADPH
REACT:R-HSA-6806610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filament formation (Homo sapiens)
REACT:R-DME-3451153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits TRRAP/KAT5 HAT components (Drosophila melanogaster)
REACT:R-SSC-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Sus scrofa)
RHEA:37505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:29406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 <=> 3-demethylubiquinol-8 + A + H2O
RHEA:28112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-chloro-5'-deoxyadenosine + L-methionine => chloride + S-adenosyl-L-methionine
REACT:R-CFA-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Canis familiaris)
GO:0003909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase activity
RHEA:16841	skos:altLabel	"S-adenosyl-L-methionine--precorrin-2 methyltransferase"
RHEA:16841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine
RHEA:16841	skos:prefLabel	"precorrin-2 C(20)-methyltransferase"
RHEA:16841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"precorrin-2 C(20)-methyltransferase"
RHEA:16841	skos:altLabel	"precorrin-2 C20-methyltransferase"
REACT:R-RNO-3928627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB phosphorylates TIAM1 (Rattus norvegicus)
RHEA:40429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:41843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctanoyl-[ACP] + NADP(+)
RHEA:71100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) => androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)
RHEA:29918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
RHEA:41258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate
RHEA:15432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine
REACT:R-SSC-1168638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated IKK phosphorylates I-kappaB (Sus scrofa)
RHEA:71554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine
RHEA:31146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH
REACT:R-SSC-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Sus scrofa)
REACT:R-HSA-8855131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9 binds Clathrin-coated vesicles (Homo sapiens)
REACT:R-RNO-606287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSF complex binds the centromere (Rattus norvegicus)
RHEA:43319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:36825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate => 1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol
GO:0102816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity
GO:0102816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP
GO:0102816	skos:prefLabel	"anthocyanidin 3-O-glucoside 5-O-glucosyltransferase"
GO:0102816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanidin 3-O-glucoside 5-O-glucosyltransferase"
REACT:R-SPO-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Schizosaccharomyces pombe)
REACT:R-CFA-372819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Canis familiaris)
GO:0008568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP phosphohydrolase (tubulin-dimerizing)
GO:0008568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule-severing ATPase activity
GO:0008568	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	katanin activity
GO:0008568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule severing ATPase activity
REACT:R-HSA-5682967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 binds DNA DSBs (Homo sapiens)
REACT:R-MMU-9708557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 binds BACH1:MAFK (Mus musculus)
GO:0047628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + thymidine = AMP + dTMP + H(+)
GO:0047628	skos:prefLabel	"ADP--thymidine kinase"
GO:0047628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP--thymidine kinase"
GO:0047628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-thymidine kinase activity
GO:0047628	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP:dThd phosphotransferase activity
GO:0047628	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP:thymidine 5'-phosphotransferase activity
GO:0047628	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphate-thymidine phosphotransferase activity
REACT:R-MMU-2454240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-FCERI gamma subunit (Mus musculus)
REACT:R-BTA-5250947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH complex binds rDNA promoter (Bos taurus)
REACT:R-HSA-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
REACT:R-CEL-6814409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates PDCL (Caenorhabditis elegans)
RHEA:13732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD <=> AMP + H(+) + riboflavin cyclic-4',5'-phosphate
RHEA:71372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone 17-sulfate(out) + 2 Na(+)(out) => epitestosterone 17-sulfate(in) + 2 Na(+)(in)
RHEA:35360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisoheptadecanoyl-CoA => (2E)-15-methylhexadecenoyl-CoA + H2O
REACT:R-HSA-5668735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX3 complex (Homo sapiens)
RHEA:36528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA => (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA
REACT:R-GGA-5654586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS binds GRB2:SOS1 (Gallus gallus)
RHEA:64888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[ACP] + tetradecanoate = AMP + diphosphate + tetradecanoyl-[ACP]
RHEA:31679	skos:altLabel	"Sol5"
RHEA:31679	skos:prefLabel	"prosolanapyrone-II oxidase"
RHEA:31679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prosolanapyrone-II oxidase"
RHEA:31679	skos:altLabel	"SPS"
RHEA:31679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prosolanapyrone II = H2O2 + prosolanapyrone III
RHEA:31679	skos:altLabel	"prosolanapyrone II oxidase/prosolanapyrone III cycloisomerase"
RHEA:15057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]
REACT:R-DRE-5618098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Danio rerio)
REACT:R-SSC-8938073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Sus scrofa)
RHEA:30921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-3,4-didehydrorhodopin + AH2 => A + rhodopin
RHEA:42406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + D-galactose 6-phosphate => H2O + lactose 6-phosphate
GO:0140340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cerebroside carrier activity
GO:0140340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cerebroside transfer activity
REACT:R-MMU-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Mus musculus)
REACT:R-RNO-6810234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Rattus norvegicus)
RHEA:17632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose(in) <=> alpha,alpha-trehalose(out)
REACT:R-XTR-199154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD200 binds to CD200R (Xenopus tropicalis)
RHEA:40078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-6-deoxyfutalosine + H(+) + H2O <=> futalosine + NH4(+)
REACT:R-SCE-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Saccharomyces cerevisiae)
RHEA:65218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoate + CoA + H(+) => 3-oxododecanoyl-CoA + H2O
REACT:R-CFA-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Canis familiaris)
RHEA:42142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine
REACT:R-SSC-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Sus scrofa)
RHEA:53839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine <=> a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]
REACT:R-DRE-9027532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DHA to 13-HDHA (Danio rerio)
REACT:R-HSA-140769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VII -> factor VIIa (Homo sapiens)
REACT:R-HSA-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Homo sapiens)
REACT:R-CEL-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Caenorhabditis elegans)
RHEA:51154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide => 2 a thiol + L-cysteinyl-[sulfatase] + O2
RHEA:27416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + codeine + O2 <=> CO2 + formaldehyde + morphine + succinate
REACT:R-BTA-445699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Bos taurus)
REACT:R-DRE-4655374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DNMT3B with SUMO1 (Danio rerio)
REACT:R-MMU-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)
REACT:R-RNO-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Rattus norvegicus)
REACT:R-RNO-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Rattus norvegicus)
REACT:R-DRE-2046285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The keratan chain can be capped by N-acetylneuraminic acid (Danio rerio)
REACT:R-MMU-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Mus musculus)
RHEA:33621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + tetradecanoyl-CoA => ATP + CoA + tetradecanoate
REACT:R-MMU-76456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-atom dealkylation of dextromethorphan (Mus musculus)
RHEA:35141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 CoA + demethoxycurcumin => (E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O
REACT:R-CFA-2186771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 binds SMAD7 (Canis familiaris)
REACT:R-GGA-532603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin mediated activation of N-WASP (Gallus gallus)
REACT:R-MMU-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Mus musculus)
REACT:R-MMU-1483159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho is dephosphorylated to Cho by PHOSPHO1 (Mus musculus)
RHEA:63891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine
REACT:R-RNO-1483063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG and CDP-DAG are converted to CL by CRLS1 (Rattus norvegicus)
RHEA:42130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine
REACT:R-HSA-622325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
REACT:R-HSA-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
REACT:R-PFA-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Plasmodium falciparum)
RHEA:35864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-DME-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Drosophila melanogaster)
RHEA:41917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]
GO:0005518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	collagen binding
RHEA:63510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroperoxy fatty acid => a 1,2-saturated fatty acid + O2
GO:0070675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Schardinger enzyme activity
GO:0070675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hypoxanthine:oxygen oxidoreductase activity
GO:0070675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hypoxanthine:O2 oxidoreductase activity
GO:0070675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine oxidase activity
GO:0070675	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hypoxanthine-xanthine oxidase activity
GO:0070675	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	xanthine oxidoreductase activity
GO:0070675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	schardinger enzyme
RHEA:19936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + H2O <=> D-glucose + phosphate
REACT:R-SSC-374899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of noradrenaline  at the synapse (Sus scrofa)
RHEA:32338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-endo-fenchol + NADP(+) <=> (1S,4R)-fenchone + H(+) + NADPH
REACT:R-GGA-74736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Gallus gallus)
REACT:R-SSC-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Sus scrofa)
REACT:R-XTR-2424243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Xenopus tropicalis)
RHEA:40543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:18670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H2O => adenine + D-ribose
RHEA:36395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + NADP(+) = 7-dehydrodesmosterol + H(+) + NADPH
RHEA:11587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine <=> D-ornithine
REACT:R-DME-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Drosophila melanogaster)
REACT:R-GGA-571327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)
RHEA:31036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabidiol => (S)-2,3-epoxysqualene + H2O
RHEA:41905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)
RHEA:30994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-112265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Rattus norvegicus)
REACT:R-CEL-1564142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV degradation by MMP2,3,4,9,10,12 (Caenorhabditis elegans)
REACT:R-DME-350403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGO binds to PK (Drosophila melanogaster)
REACT:R-BTA-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Bos taurus)
RHEA:23947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP
RHEA:34013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => 5-dehydroepisterol + 2 H2O + NADP(+)
REACT:R-RNO-169895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk's SH3 domain engages C3G (Rattus norvegicus)
RHEA:65064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + siccayne = diphosphate + pestalodiol
REACT:R-CFA-2395364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP4 binds TGF-Beta-1 (Canis familiaris)
RHEA:64896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + UTP = 2 H(+) + 2 phosphate + UMP
REACT:R-GGA-139918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BIM by JNK (Gallus gallus)
RHEA:48945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:64364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2
REACT:R-XTR-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Xenopus tropicalis)
RHEA:56073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylphloroglucinol + UDP-alpha-D-glucose => a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP
REACT:R-GGA-1236943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigen peptide onto MHC class I molecule (Gallus gallus)
REACT:R-HSA-8948222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)
RHEA:69398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA
REACT:R-DME-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Drosophila melanogaster)
REACT:R-HSA-209821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of N-acetyl-5-HT to form melatonin (Homo sapiens)
RHEA:44744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 malonyl-CoA = (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O
RHEA:44744	skos:prefLabel	"3,5-dihydroxyphenylacetyl-CoA synthase"
RHEA:44744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,5-dihydroxyphenylacetyl-CoA synthase"
RHEA:31435	skos:prefLabel	"alpha-santalene synthase"
RHEA:31435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-santalene synthase"
RHEA:31435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate
REACT:R-HSA-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Homo sapiens)
REACT:R-HSA-8985594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYO9B inactivates RHOA (Homo sapiens)
REACT:R-DRE-381466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Danio rerio)
REACT:R-CEL-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Caenorhabditis elegans)
REACT:R-DDI-507719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62:MEKK3 binds to TRAF6 (Dictyostelium discoideum)
RHEA:47427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-octadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(9Z-octadecenoyl)-CoA
REACT:R-DRE-9021601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Danio rerio)
REACT:R-CFA-9649963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC3 channel blockers bind ASIC3 trimer (Canis familiaris)
REACT:R-HSA-8876484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 transfers CHOL to NPC1 (Homo sapiens)
GO:0062180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]
GO:0062180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholecalciferol-23-hydroxylase activity
RHEA:55296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA
REACT:R-CEL-9661397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)
RHEA:42904	skos:altLabel	"tylosin-resistance methyltransferase RlmA(II)"
RHEA:42904	skos:altLabel	"23S rRNA m(1)G(748) methyltransferase"
RHEA:42904	skos:altLabel	"rRNA large subunit methyltransferase II"
RHEA:42904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (guanine(748)-N(1))-methyltransferase"
RHEA:42904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(748) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:42904	skos:prefLabel	"23S rRNA (guanine(748)-N(1))-methyltransferase"
RHEA:53913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]
REACT:R-BTA-5607004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds PRTN3:CD177 (Bos taurus)
RHEA:25489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (1S,5S)-alpha-pinene + diphosphate
RHEA:57288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + H(+) + lactate
RHEA:67010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine
REACT:R-MMU-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
REACT:R-PFA-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Plasmodium falciparum)
REACT:R-HSA-444705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R1/T1R3 dimer is the umami taste receptor (Homo sapiens)
REACT:R-MMU-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Mus musculus)
REACT:R-CEL-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Caenorhabditis elegans)
REACT:R-RNO-5668984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 or PAK2 phosphorylates MYLK (Rattus norvegicus)
REACT:R-CFA-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Canis familiaris)
REACT:R-PFA-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Plasmodium falciparum)
REACT:R-XTR-5218819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
RHEA:22180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-norreticuline + S-adenosyl-L-methionine = (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine
RHEA:35949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chanoclavine-I aldehyde + H(+) + NADPH => dihydrochanoclavine-I aldehyde + NADP(+)
GO:0033730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TyrAa
GO:0033730	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pretyrosine dehydrogenase activity
GO:0033730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arogenate dehydrogenase (NADP+) activity
GO:0033730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TyrAAT2
GO:0033730	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arogenic dehydrogenase activity
GO:0033730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TyrAAT1
GO:0033730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arogenate:NADP+ oxidoreductase (decarboxylating) activity
REACT:R-XTR-5693742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH hydrolyses AEA to AA and ETA (Xenopus tropicalis)
RHEA:48271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4',4'-dihydroxyechinenone <=> canthaxanthin + H2O
RHEA:25496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-beta-pinene synthase"
RHEA:25496	skos:altLabel	"(-)-(1S,5S)-pinene synthase"
RHEA:25496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (1S,5S)-beta-pinene + diphosphate
RHEA:25496	skos:prefLabel	"(-)-beta-pinene synthase"
RHEA:25496	skos:altLabel	"beta-geraniolene synthase"
RHEA:28583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dUDP => ADP + dUTP
REACT:R-BTA-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Bos taurus)
REACT:R-BTA-110011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Grb10 to the insulin receptor (Bos taurus)
REACT:R-HSA-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Homo sapiens)
GO:0103050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyraldehyde reductase activity
REACT:R-HSA-5661123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate Me2K5-histone H3 (Homo sapiens)
RHEA:66456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-XTR-9017797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds YBX1 (Xenopus tropicalis)
REACT:R-RNO-6803063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial LPS, PGN (Rattus norvegicus)
RHEA:56279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-proline <=> 3'-L-prolyl-AMP + diphosphate
REACT:R-SCE-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)
REACT:R-DRE-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Danio rerio)
REACT:R-XTR-190413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2c (Xenopus tropicalis)
REACT:R-GGA-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Gallus gallus)
REACT:R-DDI-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Dictyostelium discoideum)
REACT:R-HSA-877269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS-1 and SOCS-3 binds to p-JAK2 (Homo sapiens)
REACT:R-MMU-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Mus musculus)
REACT:R-HSA-9634442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLF5 gene expression is enhanced by CEBPA (Homo sapiens)
REACT:R-BTA-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Bos taurus)
RHEA:49978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine => butanoyl-CoA + H2O
REACT:R-GGA-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Gallus gallus)
REACT:R-DRE-8954110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1:EPC1 binds the PRC2 complex (Danio rerio)
REACT:R-DRE-5669013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA-3 binds EDA2R (Danio rerio)
REACT:R-DRE-176521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Danio rerio)
REACT:R-MMU-8851866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds RANBP10 (Mus musculus)
REACT:R-CFA-3640872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)
RHEA:36106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + S-adenosyl-L-methionine <=> O-methyl anthranilate + S-adenosyl-L-homocysteine
GO:0005458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-mannose transmembrane transporter activity
RHEA:45408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H(+) + NADH = dodecanoyl-CoA + NAD(+)
REACT:R-SSC-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Sus scrofa)
REACT:R-BTA-9757954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4BP1 binds IKBKG (Bos taurus)
RHEA:69570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate + L-glutamate + NH4(+) => (2S)-2-amino-4-deoxychorismate + H2O + L-glutamine
RHEA:19751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose
REACT:R-BTA-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Bos taurus)
REACT:R-XTR-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Xenopus tropicalis)
RHEA:52996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH = [eIF5A protein]-deoxyhypusine + NAD(+)
RHEA:10037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-methoxy-benzenemethanol + O2 => H2O2 + vanillin
REACT:R-SSC-114354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP:Caspase-7 (Sus scrofa)
REACT:R-HSA-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Homo sapiens)
REACT:R-HSA-8951443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 (Homo sapiens)
REACT:R-DRE-2024084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS-GAGs translocate to the lysosome for degradation (Danio rerio)
RHEA:44615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
RHEA:19046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O + pyruvate => (3R)-citramalate + CoA + H(+)
RHEA:59047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammarenediol-II + UDP-alpha-D-glucose <=> (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP
REACT:R-GGA-917807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Gallus gallus)
REACT:R-XTR-211919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F8 19-hydroxylates PGH2 (Xenopus tropicalis)
RHEA:65868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(1)-dihydrotestosterone + H2O = 1,17beta-dihydroxyandrostan-3-one
GO:0015496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine:hydrogen symporter activity
GO:0015496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine-ornithine antiporter activity
GO:0015496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine:ornithine antiporter activity
GO:0015496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine/ornithine antiporter activity
RHEA:25744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-pentahomomethionine => (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O
REACT:R-SSC-8948231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)
RHEA:27996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose + xanthine => H2O + xanthosine
RHEA:29631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraose + H2O = alpha-D-glucose + D-maltotriose
RHEA:28651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + O2 = 9-riburonosylhypoxanthine + H(+) + H2O
RHEA:28651	skos:prefLabel	"nucleoside oxidase"
RHEA:28651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside oxidase"
REACT:R-XTR-6788611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYKK phosphorylates 5HLYS (Xenopus tropicalis)
RHEA:14576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O
RHEA:11943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + L-citrulline <=> CO2 + L-ornithine + NH4(+)
REACT:R-RNO-265682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Rattus norvegicus)
REACT:R-HSA-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Homo sapiens)
REACT:R-XTR-6807875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Xenopus tropicalis)
RHEA:19270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-furoate + ATP + CoA => 2-furoyl-CoA + AMP + diphosphate
REACT:R-GGA-5669158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF2 binds PAK1 (Gallus gallus)
RHEA:60750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + pyrethrin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone
REACT:R-SCE-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)
GO:0034026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-amino-acid alpha-ligase activity
GO:0034026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-amino acid alpha-ligase activity
GO:0034026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-amino acid ligase activity
GO:0034026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	YwfE
GO:0034026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacilysin synthetase activity
RHEA:47856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate
REACT:R-HSA-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Homo sapiens)
RHEA:54700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)
REACT:R-XTR-5610767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Xenopus tropicalis)
REACT:R-SCE-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Saccharomyces cerevisiae)
RHEA:14428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
RHEA:12120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate
RHEA:12120	skos:altLabel	"ADP-glucose synthase"
RHEA:12120	skos:prefLabel	"glucose-1-phosphate adenylyltransferase"
RHEA:12120	skos:altLabel	"ADP-glucose diphosphorylase"
RHEA:12120	skos:altLabel	"ADP-glucose pyrophosphorylase"
RHEA:12120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-1-phosphate adenylyltransferase"
REACT:R-HSA-433672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 (Homo sapiens)
REACT:R-CFA-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Canis familiaris)
REACT:R-SSC-210273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and NKp44 (Sus scrofa)
RHEA:41942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate
RHEA:61552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-GGA-5654591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)
REACT:R-MMU-8865265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds MYC and KDM5B (Mus musculus)
REACT:R-RNO-975916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 5 by MGAT5 (Rattus norvegicus)
RHEA:25602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O => 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)
REACT:R-RNO-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Rattus norvegicus)
REACT:R-DME-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Drosophila melanogaster)
REACT:R-HSA-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)
REACT:R-XTR-114252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-3 by the apoptosome (Xenopus tropicalis)
REACT:R-BTA-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Bos taurus)
REACT:R-XTR-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Xenopus tropicalis)
REACT:R-CFA-5607756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomer autoubiquitinates (Canis familiaris)
REACT:R-CFA-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Canis familiaris)
EC:2.5.1.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homospermidine synthase (spermidine-specific)"
EC:2.5.1.45	skos:prefLabel	"homospermidine synthase (spermidine-specific)"
RHEA:22292	skos:altLabel	"biphenyl synthase"
RHEA:22292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + 3 H(+) + 3 malonyl-CoA = biphenyl-3,5-diol + 4 CO2 + 4 CoA
RHEA:22292	skos:altLabel	"BIS"
RHEA:22292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,5-dihydroxybiphenyl synthase"
RHEA:22292	skos:prefLabel	"3,5-dihydroxybiphenyl synthase"
REACT:R-SPO-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Schizosaccharomyces pombe)
EC:3.4.22.29	skos:prefLabel	"picornain 2A"
EC:3.4.22.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"picornain 2A"
EC:3.4.22.29	skos:altLabel	"rhinovirus protease 2A"
EC:3.4.22.29	skos:altLabel	"picornavirus endopeptidase 2A"
EC:3.4.22.29	skos:altLabel	"poliovirus protease 2A"
REACT:R-BTA-9793988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates CFLAR at K351, K353 (Bos taurus)
REACT:R-CFA-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Canis familiaris)
REACT:R-MTU-964842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Shikimate results from hydration of DHS (Mycobacterium tuberculosis)
RHEA:32541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-car-3-ene + diphosphate => (2E)-geranyl diphosphate
REACT:R-DRE-9034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 dimers trans-autophosphorylate (Danio rerio)
REACT:R-XTR-5340251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Xenopus tropicalis)
GO:0000404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	loop DNA binding
GO:0000404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heteroduplex DNA loop binding
REACT:R-SCE-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Saccharomyces cerevisiae)
REACT:R-SSC-5607004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds PRTN3:CD177 (Sus scrofa)
RHEA:25202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + formaldehyde => D-arabino-hex-3-ulose 6-phosphate
RHEA:41542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine
REACT:R-CEL-8878054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 (Caenorhabditis elegans)
REACT:R-BTA-1433542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV1 (Bos taurus)
RHEA:43133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine
REACT:R-CEL-8857662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Caenorhabditis elegans)
REACT:R-DDI-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Dictyostelium discoideum)
REACT:R-RNO-174097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdh1 (Rattus norvegicus)
RHEA:16935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + NH4(+) => 1-aminocyclopropane-1-carboxylate + H2O
REACT:R-HSA-2314686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS2 (Homo sapiens)
REACT:R-DRE-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Danio rerio)
REACT:R-DME-5687097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3 binds ETV4 (Drosophila melanogaster)
RHEA:47517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isochenodeoxycholate + NAD(+)
GO:0070224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphide:quinone oxidoreductase activity
GO:0070224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfide-quinone reductase activity
GO:0070224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfide:quinone oxidoreductase activity
REACT:R-MMU-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Mus musculus)
REACT:R-RNO-5357904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Rattus norvegicus)
RHEA:19928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 5-phosphate + NAD(+) <=> D-ribulose 5-phosphate + H(+) + NADH
RHEA:32411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,4S)-isodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH
REACT:R-MMU-70859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Mus musculus)
RHEA:57616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-ML-236C-[compactin nonaketide synthase] + H2O = dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]
REACT:R-SPO-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Schizosaccharomyces pombe)
REACT:R-HSA-4615872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO1 (Homo sapiens)
REACT:R-HSA-163489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated HSL + H2O -> HSL + orthophosphate (Homo sapiens)
REACT:R-CFA-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
REACT:R-MMU-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Mus musculus)
RHEA:12473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-ethylglycine + O2 => ethylamine + glyoxylate + H2O2
RHEA:21166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + an alcohol + H(+) => a carboxylic ester + H2O
REACT:R-CFA-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Canis familiaris)
REACT:R-HSA-193691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)
REACT:R-HSA-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Homo sapiens)
REACT:R-HSA-5658574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 binds SNCAIP (Homo sapiens)
REACT:R-DDI-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Dictyostelium discoideum)
RHEA:22719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine
EC:3.1.3.17	skos:prefLabel	"[phosphorylase] phosphatase"
EC:3.1.3.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[phosphorylase] phosphatase"
REACT:R-RNO-4085133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUM (lumican) binds integrin alpha2beta1 (Rattus norvegicus)
REACT:R-XTR-4719424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO1. (Xenopus tropicalis)
RHEA:48919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b <=> CMP + ganglioside GD1c + H(+)
RHEA:14262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + D-glucono-1,5-lactone => 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA
REACT:R-RNO-349603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Rattus norvegicus)
RHEA:47852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate
RHEA:43748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexacosanoate = AMP + diphosphate + hexacosanoyl-CoA
REACT:R-DME-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Drosophila melanogaster)
REACT:R-MMU-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Mus musculus)
GO:0140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity
GO:0140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium- and calmodulin-regulated AMP-specific phosphodiesterase activity
GO:0140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium- and calmodulin-regulated cyclic-AMP phosphodiesterase activity
GO:0140761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	calcium- and calmodulin-regulated cAMP phosphodiesterase activity
GO:0140761	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	calcium- and calmodulin-regulated 3',5'-cyclic-AMP phosphodiesterase activity
GO:0140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium/calmodulin-regulated cAMP-specific phosphodiesterase activity
RHEA:25986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-3149518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
REACT:R-SSC-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Sus scrofa)
RHEA:57340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine
RHEA:45774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->4)-beta-D-mannosyl](n) + phosphate
RHEA:35340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH
REACT:R-RNO-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Rattus norvegicus)
RHEA:43237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dihexadecanoyl-sn-glycerol + phosphate
REACT:R-RNO-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Rattus norvegicus)
REACT:R-DRE-9663511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds GSTA1, FABP1 (Danio rerio)
REACT:R-BTA-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Bos taurus)
REACT:R-HSA-350869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Homo sapiens)
GO:0016790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Thiolester hydrolases"
GO:0016790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiolester hydrolase activity
GO:0016790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiolesterase activity
GO:0016790	skos:prefLabel	"Thiolester hydrolases"
RHEA:70677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-L-phenylalanine + Met-enkephalin => H2O + Met-enkephalin-Arg-Phe
RHEA:60556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(35) in tRNA(Tyr) = pseudouridine(35) in tRNA(Tyr)
REACT:R-CFA-975902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Canis familiaris)
REACT:R-HSA-158781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Homo sapiens)
REACT:R-GGA-399933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sema3A binds Nrp-1 bound to PlexinA (Gallus gallus)
REACT:R-CFA-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Canis familiaris)
REACT:R-DRE-2213248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of antigen loaded MHC II molecules to surface (Danio rerio)
RHEA:15782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine => 3-amino-3-(4-hydroxyphenyl)propanoate
REACT:R-SPO-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Schizosaccharomyces pombe)
RHEA:63282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2
RHEA:33722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)
RHEA:27333	skos:altLabel	"HNA-3-monooxygenase"
RHEA:27333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate + 2 H(+) + NADH + O2 = 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)
RHEA:27333	skos:altLabel	"6HNA monooxygenase"
RHEA:27333	skos:prefLabel	"6-hydroxynicotinate 3-monooxygenase"
RHEA:27333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-hydroxynicotinate 3-monooxygenase"
REACT:R-GGA-453111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)
RHEA:29335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-glutamate = L-alanine + L-glutamate
RHEA:28601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-lysine <=> acetate + L-lysine
RHEA:63673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)
REACT:R-GGA-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Gallus gallus)
REACT:R-MMU-8849094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RASA1 (Mus musculus)
REACT:R-BTA-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)
REACT:R-XTR-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Xenopus tropicalis)
RHEA:14052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol
REACT:R-XTR-5686359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPs translocate from extracellular region to clathrin-coated vesicle (Xenopus tropicalis)
RHEA:18098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pteridine-2,4,6,7-tetrol => H(+) + xanthine-8-carboxylate
RHEA:70505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isopentenyl phosphate + phosphate => H2O + isopentenyl diphosphate
RHEA:69793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-phenylalanine + H(+) + tRNA(Phe) => D-phenylalanyl-tRNA(Phe) + H2O
RHEA:47727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione <=> 5-oxo-L-proline + L-cysteinylglycine
RHEA:32976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine
REACT:R-MMU-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Mus musculus)
RHEA:46856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-BTA-9759169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Bos taurus)
RHEA:60711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemal + H2O + NAD(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADH
REACT:R-HSA-9668558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBEA binds PRKAR2A (Homo sapiens)
REACT:R-CFA-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Canis familiaris)
RHEA:24395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-L-dihydrostreptose + streptidine 6-phosphate <=> dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate
GO:0047811	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine:D-alanine gamma-glutamyltransferase activity
GO:0047811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine g-glutamyltransferase activity
GO:0047811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine gamma-glutamyltransferase activity
REACT:R-DRE-383313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like Peptide 1 is secreted from intestinal L cells (Danio rerio)
REACT:R-XTR-9033499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Xenopus tropicalis)
RHEA:57706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+)
RHEA:58157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + 4 Na(+)(in) => ADP + H(+) + 4 Na(+)(out) + phosphate
GO:0034907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetanilide 1,2-dioxygenase activity
REACT:R-DME-9663511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds GSTA1, FABP1 (Drosophila melanogaster)
RHEA:45735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + L-tyrosine <=> (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate
REACT:R-HSA-2169050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)
REACT:R-DME-1855200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Drosophila melanogaster)
RHEA:70605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-ethylphenol + NAD(+) => 4-hydroxystyrene + H(+) + NADH
REACT:R-HSA-8956365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Homo sapiens)
REACT:R-DME-209925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIT and MIT combine to form triiodothyronine (Drosophila melanogaster)
REACT:R-XTR-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Xenopus tropicalis)
REACT:R-HSA-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Homo sapiens)
RHEA:65713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-glucose
REACT:R-DME-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)
RHEA:59731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ethylmalonyl-CoA <=> (2S)-ethylmalonyl-CoA
REACT:R-XTR-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Xenopus tropicalis)
GO:1990411	skos:prefLabel	"hercynylcysteine S-oxide lyase"
GO:1990411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hercynylcysteine S-oxide lyase"
GO:1990411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)
GO:1990411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide = A + ergothioneine + NH4(+) + pyruvate
REACT:R-CFA-5624131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B binds myristoylated proteins (Canis familiaris)
REACT:R-HSA-168313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Virion-associated M2 protein mediated ion infusion (Homo sapiens)
REACT:R-DRE-8876616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND6A,B exchange GTP for GDP on RAB14 (Danio rerio)
REACT:R-XTR-9707516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM dissociates from MetHb (Xenopus tropicalis)
REACT:R-CFA-2465917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerisation of 11c-retinyl to at-retinyl (Canis familiaris)
GO:0097367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate derivative binding
REACT:R-SSC-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Sus scrofa)
GO:0005278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine:proton antiporter activity
GO:0005278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine:hydrogen antiporter activity
RHEA:53650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-corvol ether A + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:25931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylquinoline + A + H2O <=> 3-methylquinolin-2(1H)-one + AH2
GO:0047843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogluconate dehydrogenase activity
GO:0047843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity
GO:0047843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxogluconate dehydrogenase activity
GO:0047843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-D-gluconate dehydrogenase activity
GO:0047843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketogluconate dehydrogenase activity
GO:0047843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketogluconate dehydrogenase activity
REACT:R-GGA-5591086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA5 binds activated protein C (Gallus gallus)
RHEA:34420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-lariciresinol + NADP(+) => (+)-pinoresinol + H(+) + NADPH
REACT:R-CFA-428205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [Golgi] (Canis familiaris)
RHEA:25693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) <=> CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate
REACT:R-HSA-6804527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INTL1 binds bacterial glycans (Homo sapiens)
GO:0036412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CoA:oxalate CoA-transferase"
GO:0036412	skos:altLabel	"acetyl-CoA oxalate CoA-transferase"
GO:0036412	skos:altLabel	"acetyl-coenzyme A transferase"
GO:0036412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA:oxalate CoA-transferase
GO:0036412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + oxalate = acetate + oxalyl-CoA
GO:0036412	skos:prefLabel	"CoA:oxalate CoA-transferase"
RHEA:48722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH => aurachin B + H2O + NAD(+)
REACT:R-CFA-191656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Closure of gap junction (Canis familiaris)
RHEA:55670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinal--[retinol-binding protein] + H(+) + NADH => 11-cis-retinol--[retinol-binding protein] + NAD(+)
REACT:R-HSA-5676592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xRANK binds RANKL,sRANKL trimer:RANK (Homo sapiens)
REACT:R-BTA-6793661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Bos taurus)
REACT:R-DDI-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-SSC-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Sus scrofa)
REACT:R-SPO-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Schizosaccharomyces pombe)
REACT:R-HSA-8853745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA3 (Homo sapiens)
REACT:R-HSA-390224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Homo sapiens)
REACT:R-SSC-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Sus scrofa)
REACT:R-SSC-5225649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP7 binds histone H3 (Sus scrofa)
REACT:R-MMU-193497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Mus musculus)
REACT:R-DRE-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Danio rerio)
REACT:R-DRE-170153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Danio rerio)
RHEA:17834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + S-adenosyl-L-methionine => 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine
RHEA:41707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)
REACT:R-MMU-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Mus musculus)
RHEA:43143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(26) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine
REACT:R-HSA-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Homo sapiens)
EC:3.2.1.n2	skos:prefLabel	"blood group B linear chain alpha-1,3-galactosidase"
EC:3.2.1.n2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"blood group B linear chain alpha-1,3-galactosidase"
REACT:R-GGA-6784323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Gallus gallus)
REACT:R-HSA-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Homo sapiens)
GO:0008679	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-glycerate:NAD(P)+ oxidoreductase activity
GO:0008679	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tartronate semialdehyde reductase (NADPH) activity
GO:0008679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH
GO:0008679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxopropionate reductase activity
REACT:R-BTA-4341025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR3C1 (GR) with SUMO1 (Bos taurus)
REACT:R-DME-209135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GISH further phosphorylates ARR in the receptor complex (Drosophila melanogaster)
REACT:R-XTR-2028724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind YAP1 (Xenopus tropicalis)
REACT:R-BTA-77331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Bos taurus)
REACT:R-RNO-2395869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
GO:0043720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-keto-5-aminohexanoate cleavage enzyme"
GO:0043720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-amino-3-oxohexanoate + acetyl-CoA = (3S)-3-aminobutanoyl-CoA + acetoacetate
GO:0043720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-keto-5-aminohexanoate cleavage activity
GO:0043720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-keto-5-aminohexanoate cleavage enzyme
GO:0043720	skos:prefLabel	"3-keto-5-aminohexanoate cleavage enzyme"
RHEA:63802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-gulose => GDP-alpha-D-mannose
REACT:R-MMU-166792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C2 into C2a and C2b (Mus musculus)
RHEA:45857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-XTR-1630304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Xenopus tropicalis)
RHEA:12169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allyl alcohol + NADP(+) => acrolein + H(+) + NADPH
REACT:R-HSA-6811414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF (Homo sapiens)
RHEA:15144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol + H2O + 4 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]
RHEA:20507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline + an L-alpha-amino acid => an alpha-(gamma-L-glutamyl)-L-amino acid
REACT:R-MMU-9749986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Mus musculus)
RHEA:36373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + H(+) + NADH => (2S)-hydroxybutanoate + NAD(+)
RHEA:37342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O <=> (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)
RHEA:29082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + ubiquinone-8 <=> pyruvate + ubiquinol-8
GO:0047733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPglucose 4,6-dehydratase activity
GO:0047733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glucose 4,6-dehydratase activity
GO:0047733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-glucose 4,6-hydro-lyase activity
GO:0047733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)
GO:0047733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPglucose 4,6-hydro-lyase activity
GO:0047733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoglucose oxidoreductase activity
REACT:R-HSA-8863973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of ERC and phagosome (Homo sapiens)
RHEA:49308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose
RHEA:19567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sabinene hydrate => (2E)-geranyl diphosphate + H2O
GO:0047817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arginase activity
GO:0047817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arginine amidinohydrolase activity
REACT:R-HSA-8878257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds the IHH gene promoter (Homo sapiens)
REACT:R-SCE-200423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Saccharomyces cerevisiae)
REACT:R-CFA-6800198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Canis familiaris)
REACT:R-SSC-5362525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1,C1 4-hydroxylate atRA (Sus scrofa)
REACT:R-DRE-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Danio rerio)
REACT:R-MMU-73912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Mus musculus)
REACT:R-RNO-8983300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Rattus norvegicus)
REACT:R-RNO-8952039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
RHEA:18844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NADP(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADPH
REACT:R-HSA-1791076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ADD1 (Adducin alpha) (Homo sapiens)
REACT:R-DRE-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Danio rerio)
GO:0050589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity
GO:0050589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucoanthocyanidin dioxygenase activity
GO:0050589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucoanthocyanidin hydroxylase
GO:0050589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthocyanidin synthase activity
GO:0050589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucocyanidin oxygenase activity
RHEA:13844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(II)2-[transferrin] + H(+) + NAD(+) <=> Fe(III)2-[transferrin] + NADH
REACT:R-XTR-5684261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K8 is phosphorylated (Xenopus tropicalis)
REACT:R-DRE-3215251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53INP1 and HIPK2 bind TP53 (Danio rerio)
REACT:R-CEL-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Caenorhabditis elegans)
RHEA:69257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + progoitrin => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
RHEA:19530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovitexin + UDP-alpha-D-glucose => H(+) + isovitexin 2''-O-beta-D-glucoside + UDP
REACT:R-CFA-211874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2S1 4-hydroxylates atRA (Canis familiaris)
GO:0086063	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential
GO:0086063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential
GO:0086063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in SA node cell action potential
GO:0086063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential
GO:0086063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential
EC:2.1.1.268	skos:prefLabel	"tRNA(Thr) (cytosine(32)-N(3))-methyltransferase"
EC:2.1.1.268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Thr) (cytosine(32)-N(3))-methyltransferase"
REACT:R-CEL-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Caenorhabditis elegans)
RHEA:39741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,12-dihydroxydodecanoate + H2O + NADP(+) => 3-hydroxydodecanoate + H(+) + NADPH + O2
REACT:R-BTA-9028255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises EPA to PGH3 (Bos taurus)
REACT:R-SSC-8950405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Sus scrofa)
RHEA:56733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dihydroxy-all-trans-beta-carotene => echinenone + H2O
RHEA:11298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 2 H(+) + NADPH => 2,5-dioxopentanoate + H2O + NADP(+)
REACT:R-XTR-981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3 convertases spontaneously dissociate (Xenopus tropicalis)
RHEA:44825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine
RHEA:30565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan
REACT:R-HSA-9665809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F8 variant does not bind von Willebrand factor (Homo sapiens)
REACT:R-MMU-8957241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP73 tetramer translocates to the nucleus (Mus musculus)
REACT:R-RNO-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Rattus norvegicus)
RHEA:33678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) <=> H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2
REACT:R-RNO-162830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)
REACT:R-BTA-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)
GO:0030555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA modification guide activity
REACT:R-RNO-190413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2c (Rattus norvegicus)
REACT:R-MMU-2130641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TGN-lysosome vesicle to lysosome (Mus musculus)
REACT:R-HSA-4341073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates PGR with SUMO1 (Homo sapiens)
RHEA:12888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) <=> GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)
REACT:R-DRE-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Danio rerio)
RHEA:65886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + xanthurenate => 2-oxoglutarate + 3-hydroxy-L-kynurenine
RHEA:16533	skos:prefLabel	"protein N-acetylglucosaminyltransferase"
RHEA:16533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP
RHEA:16533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein N-acetylglucosaminyltransferase"
RHEA:16533	skos:altLabel	"N-GlcNAc transferase"
REACT:R-DME-2002460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB binds Collagen chains (Drosophila melanogaster)
RHEA:55290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + tetradecanyl tetradecanoate => tetradecan-1-ol + tetradecanoyl-CoA
RHEA:67910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + H(+) + sulfate => a primary linear alkyl sulfate ester + H2O
REACT:R-HSA-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)
RHEA:60646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+) => 3'-phosphoadenylyl sulfate + androsterone
REACT:R-CFA-5693609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53 at S15 (Canis familiaris)
EC:4.2.2.21	skos:altLabel	"chondroitinase"
EC:4.2.2.21	skos:prefLabel	"chondroitin-sulfate-ABC exolyase"
EC:4.2.2.21	skos:altLabel	"chondroitin ABC eliminase"
EC:4.2.2.21	skos:altLabel	"ChS ABC lyase"
EC:4.2.2.21	skos:altLabel	"chondroitin ABC lyase"
EC:4.2.2.21	skos:altLabel	"chondroitin sulfate ABC exolyase"
EC:4.2.2.21	skos:altLabel	"chondroitinase ABC"
EC:4.2.2.21	skos:altLabel	"ChS ABC lyase II"
EC:4.2.2.21	skos:altLabel	"chondroitin sulfate ABC exoeliminase"
EC:4.2.2.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chondroitin-sulfate-ABC exolyase"
EC:4.2.2.21	skos:altLabel	"chondroitin sulfate ABC lyase"
REACT:R-CFA-3371353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble TNF-α binds TNFR1 (Canis familiaris)
RHEA:64250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-decanoylglycine => decanoyl-CoA + glycine
RHEA:34651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine
RHEA:66015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O
RHEA:24747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine => 2-aminobut-2-enoate + methanethiol
REACT:R-CEL-420977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca permeable AMPA receptor ligand binding (Caenorhabditis elegans)
RHEA:35987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
GO:0050368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine 2,3-aminomutase activity
GO:0050368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine alpha,beta-mutase activity
GO:0050368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine 2,3-aminomutase activity
REACT:R-RNO-8938217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SWI/SNF complex (Rattus norvegicus)
REACT:R-MMU-175987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from AdoMet to PY (Mus musculus)
RHEA:45905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + epivancomycin + H(+)
RHEA:19334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxalyl-CoA => CO2 + formyl-CoA
REACT:R-DRE-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Danio rerio)
RHEA:40439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-beta-D-quinovose = 6-deoxy-6-sulfo-D-fructose
RHEA:40439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfoquinovose isomerase"
RHEA:40439	skos:prefLabel	"sulfoquinovose isomerase"
RHEA:40439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-beta-D-quinovose = 6-sulfo-D-rhamnose
REACT:R-RNO-2467794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of sister chromatids (Rattus norvegicus)
RHEA:51421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S,3S)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH
RHEA:47441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) => 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH
REACT:R-GGA-139855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X1-mediated entry of Ca++ from plasma (Gallus gallus)
REACT:R-HSA-390250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Homo sapiens)
RHEA:47126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexacosanoylglycine => glycine + hexacosanoate
EC:1.1.1.270	skos:altLabel	"3-keto-steroid reductase"
EC:1.1.1.270	skos:prefLabel	"3beta-hydroxysteroid 3-dehydrogenase"
EC:1.1.1.270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3beta-hydroxysteroid 3-dehydrogenase"
EC:1.1.1.270	skos:altLabel	"3-KSR"
RHEA:25656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-oxobutanoate + H(+) <=> aminoacetone + CO2
REACT:R-CEL-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)
REACT:R-HSA-9670414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT mutants bind SFKs (Homo sapiens)
REACT:R-GGA-4341073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates PGR with SUMO1 (Gallus gallus)
REACT:R-HSA-1370505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR is phosphorylated at Ser-349 (Homo sapiens)
REACT:R-DME-8865482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KMT2A (MLL) binds RUNX1 (Drosophila melanogaster)
RHEA:29041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-aspartate(in) + phosphate => ATP + H2O + L-aspartate(out)
REACT:R-MMU-3095889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC dealkylates RCbl (Mus musculus)
REACT:R-RNO-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Rattus norvegicus)
RHEA:67113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine
GO:0035877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	death effector domain binding
GO:0035877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DED binding
REACT:R-HSA-1679098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Homo sapiens)
GO:0023023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC protein complex binding
RHEA:41581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate => 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate
RHEA:17686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + uracil 5-carboxylate => CO2 + uracil
REACT:R-GGA-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Gallus gallus)
REACT:R-DDI-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Dictyostelium discoideum)
REACT:R-GGA-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Gallus gallus)
RHEA:20264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7-trioxododecanoyl-CoA <=> CO2 + CoA + olivetol
RHEA:25075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O
REACT:R-HSA-9619667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRX gene expression (Homo sapiens)
REACT:R-GGA-8877760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Gallus gallus)
REACT:R-DME-1971483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Drosophila melanogaster)
REACT:R-RNO-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Rattus norvegicus)
REACT:R-DDI-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)
REACT:R-DRE-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Danio rerio)
REACT:R-CEL-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Caenorhabditis elegans)
RHEA:22409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + isopentenyl diphosphate => (2E)-geranyl diphosphate + diphosphate
REACT:R-CFA-9021050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 oligomer binds ESRs (Canis familiaris)
RHEA:13734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an n-alkanal + NAD(+) => an alk-2-enal + H(+) + NADH
RHEA:60208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate
RHEA:60208	skos:prefLabel	"[histone H3]-trimethyl-L-lysine(4) demethylase"
RHEA:60208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-trimethyl-L-lysine(4) demethylase"
REACT:R-SSC-209087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBA is phosphorylated by Phospho IKKB kinase (Sus scrofa)
RHEA:28128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose
REACT:R-BTA-4551679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO2 (Bos taurus)
REACT:R-DME-3928645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB:NMDAR binds TIAM1 (Drosophila melanogaster)
GO:0008387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 7-alpha-hydroxylase activity
GO:0008387	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2A12
REACT:R-BTA-444705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R1/T1R3 dimer is the umami taste receptor (Bos taurus)
REACT:R-HSA-9687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8b binds MAP1LC3B (Homo sapiens)
REACT:R-DME-9757954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4BP1 binds IKBKG (Drosophila melanogaster)
RHEA:21645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycerol => ADP + H(+) + sn-glycerol 3-phosphate
REACT:R-DME-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Drosophila melanogaster)
GO:0019771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	high affinity Fc receptor activity
GO:0019771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity IgG receptor activity
GO:0019771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity IgG receptor activity
REACT:R-HSA-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Homo sapiens)
REACT:R-CEL-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Caenorhabditis elegans)
REACT:R-XTR-2130641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TGN-lysosome vesicle to lysosome (Xenopus tropicalis)
REACT:R-SPO-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
RHEA:52921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP
EC:3.4.14.-	skos:prefLabel	"Dipeptidyl-peptidases and tripeptidyl-peptidases"
EC:3.4.14.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Dipeptidyl-peptidases and tripeptidyl-peptidases"
GO:0035851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAB domain binding
GO:0035851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Krueppel-associated box binding
GO:0035851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Krueppel-associated box domain binding
RHEA:70446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 <=> a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate
REACT:R-HSA-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Homo sapiens)
GO:0018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammeline + H(+) + H2O = ammelide + NH4(+)
GO:0018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammeline aminohydrolase activity
GO:0018756	skos:prefLabel	"melamine deaminase"
GO:0018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"melamine deaminase"
GO:0018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + melamine = ammeline + NH4(+)
REACT:R-HSA-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Homo sapiens)
REACT:R-GGA-4093332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHB phosphorylates SDC2 (Gallus gallus)
REACT:R-MMU-9654523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP bind PDE6D on KRAS4B (Mus musculus)
REACT:R-BTA-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Bos taurus)
RHEA:58046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA => a long-chain fatty acyl-CoA + alpha,alpha-trehalose
REACT:R-HSA-4331327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds PMAIP1 (NOXA) promoter (Homo sapiens)
RHEA:17868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydropteridine + NADP(+) <=> 6,7-dihydropteridine + H(+) + NADPH
RHEA:28716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate(in) + 2 H(+)(in) => (R)-malate(out) + 2 H(+)(out)
RHEA:47227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-5624948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF17 enters the cilium (Caenorhabditis elegans)
RHEA:11106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hercynine + S-adenosyl-L-homocysteine => N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine
REACT:R-SCE-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Saccharomyces cerevisiae)
RHEA:52403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-D-threonate + NAD(+) <=> 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH
REACT:R-HSA-933525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and release of IRF7 (Homo sapiens)
REACT:R-HSA-381203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus (Homo sapiens)
RHEA:68486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + undecanal => (2R)-2-hydroperoxydodecanoate + H(+)
RHEA:18897	skos:altLabel	"iodothyronine inner ring monodeiodinase"
RHEA:18897	skos:altLabel	"type III iodothyronine deiodinase"
RHEA:18897	skos:altLabel	"diiodothyronine 5'-deiodinase"
RHEA:18897	skos:prefLabel	"thyroxine 5-deiodinase"
RHEA:18897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thyroxine 5-deiodinase"
RHEA:18897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine
RHEA:18897	skos:altLabel	"iodothyronine 5-deiodinase"
GO:0008463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formylmethionine deformylase activity
GO:0008463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-formyl-L-methionine amidohydrolase activity
REACT:R-RNO-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Rattus norvegicus)
RHEA:19123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an S-substituted glutathione(out) + H(+) + phosphate => an S-substituted glutathione(in) + ATP + H2O
REACT:R-XTR-373717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacts with DIP13alpha (Xenopus tropicalis)
GO:0102534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin-7,4'-dimethyl ether 6-hydroxylase activity
REACT:R-SPO-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Schizosaccharomyces pombe)
REACT:R-XTR-1912369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH precursor cleaved to form mature NOTCH (Xenopus tropicalis)
RHEA:43436	skos:prefLabel	"coproporphyrinogen III oxidase (coproporphyrin-forming)"
RHEA:43436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2
RHEA:43436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coproporphyrinogen III oxidase (coproporphyrin-forming)"
RHEA:45730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeyl aldehyde + H(+) + NADPH => (E)-caffeyl alcohol + NADP(+)
REACT:R-RNO-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Rattus norvegicus)
REACT:R-BTA-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Bos taurus)
RHEA:34016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => ergosterol + 2 H2O + NADP(+)
REACT:R-MMU-5690870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Mus musculus)
REACT:R-HSA-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)
RHEA:13858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + H2O => a dolichyl phosphate + D-glucose + H(+)
REACT:R-XTR-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Xenopus tropicalis)
REACT:R-RNO-1462023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-pro-defensins are cleaved to remove the signal peptide (Rattus norvegicus)
REACT:R-DME-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Drosophila melanogaster)
RHEA:68084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-histidyl-[RNA ligase] = diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epidermal growth factor receptor binding
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	epidermal growth factor
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF receptor binding
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor alpha receptor binding
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGF-alpha receptor binding
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binding
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFalpha receptor binding
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transforming growth factor alpha receptor ligand
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	EGF
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	epidermal growth factor receptor ligand
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	EGF receptor ligand
GO:0005154	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transforming growth factor alpha
RHEA:12581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + tauropine => H(+) + NADH + pyruvate + taurine
RHEA:17553	skos:prefLabel	"opheline kinase"
RHEA:17553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanidinoethyl methyl phosphate = ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate
RHEA:17553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"opheline kinase"
RHEA:46758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-159819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Bos taurus)
REACT:R-DRE-9614273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGRG heterodimer translocates to plasma membrane (Danio rerio)
RHEA:27674	skos:altLabel	"nucleoside 5'-diphosphate phosphotransferase"
RHEA:27674	skos:altLabel	"NDK"
RHEA:27674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside-diphosphate kinase"
RHEA:27674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dADP = ADP + dATP
RHEA:27674	skos:prefLabel	"nucleoside-diphosphate kinase"
RHEA:27674	skos:altLabel	"nucleoside diphosphokinase"
RHEA:42193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Bos taurus)
REACT:R-RNO-3159253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAB adenosylates cob(I)alamin (Rattus norvegicus)
REACT:R-DRE-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Danio rerio)
RHEA:69583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + inosine <=> 2'-deoxyguanosine + IMP
RHEA:43886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-22-oyl-CoA + NAD(+)
RHEA:20378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH
RHEA:15486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-homoisocitrate => cis-homoaconitate + H2O
RHEA:23818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + L-glutamate => 2-oxoglutarate + putrescine
RHEA:34174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate 4-semialdehyde + pyruvate <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O
REACT:R-CEL-2046084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Caenorhabditis elegans)
RHEA:14891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,7E,9E,14Z,17Z)-icosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate
RHEA:52808	skos:prefLabel	"U6 snRNA m(6)A methyltransferase"
RHEA:52808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"U6 snRNA m(6)A methyltransferase"
RHEA:52808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine in U6 snRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine
RHEA:18373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol-4-phosphate 3-kinase"
RHEA:18373	skos:prefLabel	"phosphatidylinositol-4-phosphate 3-kinase"
RHEA:18373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)
RHEA:18373	skos:altLabel	"phosphoinositide 3-kinase"
RHEA:18373	skos:altLabel	"C2-domain-containing phosphoinositide 3-kinase"
RHEA:18373	skos:altLabel	"type II phosphoinositide 3-kinase"
RHEA:10475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,3-dimethylmalate <=> propanoate + pyruvate
REACT:R-SSC-202939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of E-Cadherin (Sus scrofa)
REACT:R-PFA-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Plasmodium falciparum)
RHEA:16910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + glycine + H2O => 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)
REACT:R-GGA-8951498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Gallus gallus)
REACT:R-BTA-388900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurotensin receptors can bind neurotensins (Bos taurus)
REACT:R-CFA-9032798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK3 activates RAC1 (Canis familiaris)
REACT:R-SSC-5668481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)
RHEA:15561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + sterigmatocystin = 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Danio rerio)
REACT:R-HSA-9690896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOX9 and GATA4 bind the DMRT1 gene (Homo sapiens)
REACT:R-GGA-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Gallus gallus)
RHEA:60313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-GGA-389158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
REACT:R-CFA-9692809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the ER membrane (Canis familiaris)
REACT:R-DRE-1006169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds host cell surface markers (Danio rerio)
RHEA:29025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-fucose(out) => H(+)(in) + L-fucose(in)
REACT:R-XTR-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Xenopus tropicalis)
RHEA:33002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
GO:0004592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantothenate synthetase activity
GO:0004592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pantoate-beta-alanine ligase activity
GO:0004592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantoic-activating enzyme activity
GO:0004592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantoate-activating enzyme activity
GO:0004592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-pantoate:beta-alanine ligase (AMP-forming)
GO:0004592	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-pantoate:beta-alanine ligase (AMP-forming)
RHEA:64699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl alcohol + NAD(+) <=> benzaldehyde + H(+) + NADH
REACT:R-RNO-194632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Rattus norvegicus)
REACT:R-XTR-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Xenopus tropicalis)
REACT:R-CFA-209738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 binds GC (Canis familiaris)
REACT:R-RNO-2424481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)
REACT:R-RNO-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Rattus norvegicus)
RHEA:16150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide
REACT:R-SSC-8851538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside triphosphates (Sus scrofa)
REACT:R-BTA-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Bos taurus)
REACT:R-CEL-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)
RHEA:20876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-benzylsuccinyl-CoA dehydrogenase"
RHEA:20876	skos:prefLabel	"(R)-benzylsuccinyl-CoA dehydrogenase"
RHEA:20876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-DME-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Drosophila melanogaster)
REACT:R-DME-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Drosophila melanogaster)
RHEA:38294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl-CoA + H2O <=> (S)-malate + CoA + H(+)
REACT:R-CFA-5684887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of CHEK1 at resected DNA DSBs (Canis familiaris)
GO:0023025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class Ib protein complex binding
REACT:R-DRE-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Danio rerio)
REACT:R-SSC-194632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Sus scrofa)
RHEA:72131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine(out) = agmatine(in)
RHEA:68380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + L-asparagine = 2-oxosuccinamate + L-serine
GO:0047820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate cyclase activity
GO:0047820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)
GO:0047820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamate hydro-lyase (cyclizing)
RHEA:27436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione amide + NAD(+) <=> glutathione amide disulfide + H(+) + NADH
REACT:R-SCE-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Saccharomyces cerevisiae)
REACT:R-XTR-446391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the PINCH-ILK-parvin complex (Xenopus tropicalis)
REACT:R-BTA-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Bos taurus)
REACT:R-XTR-997326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Xenopus tropicalis)
REACT:R-DRE-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Danio rerio)
RHEA:22726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sterol 3-beta-D-glucoside + H(+) + UDP => a sterol + UDP-alpha-D-glucose
GO:0042300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidosqualene:beta-amyrin cyclase activity
GO:0042300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin synthase activity
REACT:R-DRE-5689000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Danio rerio)
RHEA:72616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-valine(out) => H(+)(in) + L-alanyl-L-valine(in)
RHEA:54208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O
REACT:R-HSA-5696356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSCAR binds collagen and SP-D (Homo sapiens)
REACT:R-CEL-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Caenorhabditis elegans)
RHEA:44094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + nonadecanoyl-CoA => ATP + CoA + nonadecanoate
RHEA:62404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyhexadecanoate + O2 = CO2 + H2O + pentadecanoate
RHEA:62404	skos:prefLabel	"2-hydroxy fatty acid dioxygenase"
RHEA:62404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy fatty acid dioxygenase"
REACT:R-CEL-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Caenorhabditis elegans)
RHEA:23418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate + phosphate => (2R)-O-phospho-3-sulfolactate + H2O
REACT:R-MMU-374207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled estrogen receptor 1 binds estrogen non-classically (Mus musculus)
REACT:R-CFA-174441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Canis familiaris)
REACT:R-HSA-71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Homo sapiens)
RHEA:32404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S,4R)-neodihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH
REACT:R-CFA-72143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lariat Formation and 5'-Splice Site Cleavage (Canis familiaris)
REACT:R-GGA-77586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Gallus gallus)
REACT:R-SSC-9629470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Sus scrofa)
REACT:R-RNO-9018895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Rattus norvegicus)
RHEA:32425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carvone + AH2 => (1R,4R)-dihydrocarvone + A
RHEA:52419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-O-phospho-D-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate
REACT:R-BTA-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)
RHEA:10093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 3'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate
REACT:R-HSA-83656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)
RHEA:31133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => 5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide
EC:3.4.24.72	skos:prefLabel	"fibrolase"
EC:3.4.24.72	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fibrolase"
EC:3.4.24.72	skos:altLabel	"fibrinolytic proteinase"
REACT:R-CEL-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Caenorhabditis elegans)
RHEA:57126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-oxoproline => 2-oxoglutaramate
GO:0140628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	outward rectifier potassium channel inhibitor activity
RHEA:67749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate
REACT:R-SCE-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Saccharomyces cerevisiae)
RHEA:14740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP <=> 3',5'-cyclic CMP + diphosphate
RHEA:71476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin => L-isoleucyl-L-leucine + neurotensin(1-11)
REACT:R-XTR-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Xenopus tropicalis)
REACT:R-HSA-198315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)
REACT:R-CFA-77277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Canis familiaris)
RHEA:13462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)
RHEA:50919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + ATP + H(+) + NADPH <=> AMP + an aldehyde + diphosphate + NADP(+)
RHEA:47731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)
RHEA:40413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol
REACT:R-SPO-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Schizosaccharomyces pombe)
REACT:R-SSC-8941623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
REACT:R-HSA-5603297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC35D1 does not transport UDP-GlcA, UDPGlcNAc (Homo sapiens)
RHEA:45104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-demethylmitomycin A + S-adenosyl-L-methionine = mitomycin A + S-adenosyl-L-homocysteine
REACT:R-DME-201475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with R-Smad1/5/8 for type I receptor (Drosophila melanogaster)
REACT:R-HSA-211731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK-2p34 with RGH10/ PS-GAP results in accumulation of PAK-2p34 in the perinuclear region (Homo sapiens)
REACT:R-GGA-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Gallus gallus)
RHEA:32689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + tricyclene => (2E)-geranyl diphosphate
RHEA:56258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-BTA-5602080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Bos taurus)
REACT:R-HSA-9733216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 (Homo sapiens)
REACT:R-HSA-9009700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RB and IL2RG are phosphorylated (Homo sapiens)
RHEA:53855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate + NAD(+) <=> 7-oxo-glycodeoxycholate + H(+) + NADH
REACT:R-DRE-9688838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds STUB1 (Danio rerio)
REACT:R-RNO-9603987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Rattus norvegicus)
REACT:R-XTR-9678561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Xenopus tropicalis)
REACT:R-XTR-349444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of COP1 at Ser-387  by ATM (Xenopus tropicalis)
RHEA:15240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c2] + NADPH <=> 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)
RHEA:40690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol <=> 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-MMU-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Mus musculus)
REACT:R-SSC-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Sus scrofa)
REACT:R-RNO-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Rattus norvegicus)
REACT:R-HSA-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)
RHEA:60934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:63394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + Fe(II)-heme i => A + Fe(II)-heme o + H2O
REACT:R-BTA-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Bos taurus)
REACT:R-MMU-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)
RHEA:48666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:71617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + sulfate(in) => (S)-malate(in) + sulfate(out)
RHEA:14282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + sulfite => 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate
RHEA:44571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) <=> 2-all-trans-hexaprenylphenol + CO2
GO:0050332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin pyridinolase activity
GO:0050332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine pyridinolase activity
GO:0050332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity
GO:0050332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine hydrolase activity
GO:0050332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin hydrolase activity
GO:0050332	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thiaminase I activity
GO:0050332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity
GO:0050332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine transferase activity
GO:0050332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine pyridinylase activity
GO:0050332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin pyridinylase activity
GO:0102595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity
REACT:R-SPO-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Schizosaccharomyces pombe)
REACT:R-HSA-390276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA (Homo sapiens)
REACT:R-HSA-1855202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Homo sapiens)
REACT:R-SSC-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Sus scrofa)
REACT:R-HSA-265166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Insulin (Homo sapiens)
RHEA:12513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate + H2O + O2 => H2O2 + NH4(+) + oxaloacetate
RHEA:11072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 3 H(+) + NADPH + O2 = catechol + CO2 + NADP(+) + NH4(+)
REACT:R-MMU-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Mus musculus)
RHEA:63413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trichlorophenol + FADH2 + O2 => 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O
GO:0018791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity
REACT:R-CFA-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Canis familiaris)
REACT:R-DRE-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Danio rerio)
REACT:R-SSC-70333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KHK dimer phosphorylates Fru to Fru 1-P (Sus scrofa)
REACT:R-RNO-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)
RHEA:34059	skos:prefLabel	"agroclavine dehydrogenase"
RHEA:34059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"agroclavine dehydrogenase"
RHEA:34059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agroclavine + NADP(+) = didehydroagroclavine + H(+) + NADPH
RHEA:70970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) <=> 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)
REACT:R-XTR-4088024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Xenopus tropicalis)
REACT:R-XTR-4641253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 ubiquitinates FZD to promote its downregulation (Xenopus tropicalis)
RHEA:64077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)
RHEA:36175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkylglycerone 3-phosphate + H(+) + NADPH = 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)
RHEA:11064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate
RHEA:11064	skos:altLabel	"fructose 1,6-bisphosphatase"
RHEA:11064	skos:altLabel	"hexose diphosphatase"
RHEA:11064	skos:prefLabel	"fructose-bisphosphatase"
RHEA:11064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructose-bisphosphatase"
REACT:R-RNO-1296035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Rattus norvegicus)
REACT:R-DDI-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Dictyostelium discoideum)
REACT:R-CEL-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Caenorhabditis elegans)
REACT:R-CEL-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Caenorhabditis elegans)
RHEA:45957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA(in) => (9Z)-octadecenoyl-CoA(out)
REACT:R-HSA-5668714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX1 complex (Homo sapiens)
REACT:R-DME-1602458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP10 (Drosophila melanogaster)
REACT:R-HSA-211164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO1A (Homo sapiens)
REACT:R-HSA-77615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR2) (Homo sapiens)
RHEA:28725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin(out) + H(+)(out) => (S)-allantoin(in) + H(+)(in)
RHEA:69105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + L-kynurenine => H2O + kynurenate + L-cysteine
REACT:R-SSC-9033509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5L (Sus scrofa)
RHEA:66808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH = 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A
GO:0005359	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	low-affinity hydrogen:glucose transporter activity
GO:0005359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity hydrogen:glucose symporter activity
GO:0005359	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	low-affinity hydrogen/glucose transporter activity
GO:0005359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity glucose:proton symporter activity
RHEA:12726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-iditol + NAD(+) => H(+) + keto-D-sorbose + NADH
REACT:R-SSC-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Sus scrofa)
RHEA:12608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H(+) + pyruvate <=> 1-deoxy-D-xylulose 5-phosphate + CO2
REACT:R-SCE-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Saccharomyces cerevisiae)
REACT:R-SSC-165708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated 4EBP1 from eIF4E (Sus scrofa)
RHEA:37034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O
GO:0047242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyanthraquinone glucosyltransferase activity
GO:0047242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthraquinone-specific glucosyltransferase activity
GO:0047242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity
GO:0047242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-anthraquinone glucosyltransferase activity
GO:0047242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity
REACT:R-HSA-110208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTHL1 glycosylase mediated recognition and binding of cytosine glycol (Homo sapiens)
REACT:R-GGA-9621179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cinaciguat binds sGC:NO (Gallus gallus)
RHEA:38291	skos:prefLabel	"(3S)-malyl-CoA thioesterase"
RHEA:38291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl-CoA + H2O = (S)-malate + CoA + H(+)
RHEA:38291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(3S)-malyl-CoA thioesterase"
REACT:R-BTA-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Bos taurus)
REACT:R-DRE-9033509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5L (Danio rerio)
RHEA:37968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NADP(+) => D-galactose + H(+) + NADPH
REACT:R-DME-1602473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP1 (Drosophila melanogaster)
RHEA:43491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyll a + NAD(+) <=> chlorophyll b + H(+) + NADH
REACT:R-SSC-202702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD177 binds PECAM-1 (Sus scrofa)
RHEA:57006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(beta)-acetylstreptothricin D => acetyl-CoA + streptothricin D
REACT:R-MMU-8952062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 recruits HDAC4 to RUNX3 (Mus musculus)
REACT:R-HSA-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Homo sapiens)
REACT:R-HSA-75090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR1 homodimer to dsRNA duplex (Homo sapiens)
REACT:R-DDI-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Dictyostelium discoideum)
REACT:R-MMU-418845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of caspase-3 (Mus musculus)
RHEA:52331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + O2 + reduced [flavodoxin] <=> H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]
REACT:R-HSA-6803988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2O3 enters bacteria (Homo sapiens)
RHEA:11083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + H2O <=> phosphate + thymidine
REACT:R-GGA-9697747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at TNFR signaling complex (Gallus gallus)
GO:0045510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-24 binding
GO:0045510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-24 binding
REACT:R-DME-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Drosophila melanogaster)
REACT:R-HSA-200318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Homo sapiens)
RHEA:37867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-8983061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSLP binds CRLF2:IL7R (Homo sapiens)
REACT:R-HSA-191790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)
RHEA:66271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + nonanoyl-AMP <=> AMP + H(+) + nonanoyl-CoA
REACT:R-GGA-9645535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 phosphorylates TIFA (Gallus gallus)
RHEA:17969	skos:altLabel	"L-lysine-adding enzyme"
RHEA:17969	skos:prefLabel	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase"
RHEA:17969	skos:altLabel	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase"
RHEA:17969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase"
RHEA:17969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
RHEA:17969	skos:altLabel	"MurE synthetase"
RHEA:17969	skos:altLabel	"UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase"
RHEA:17969	skos:altLabel	"uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase"
RHEA:53124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene = delta-carotene
REACT:R-MMU-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Mus musculus)
REACT:R-SSC-1678694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Sus scrofa)
REACT:R-XTR-8938829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Xenopus tropicalis)
RHEA:19380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + reduced riboflavin <=> 2 H(+) + NADPH + riboflavin
RHEA:19984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADPH + S-formylglutathione
REACT:R-RNO-5620975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PIPs (Rattus norvegicus)
REACT:R-MMU-9006850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor JAK phosphorylation (Mus musculus)
GO:0102435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin 7-O-methyltransferase activity
RHEA:59708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotriono-1,5-lactone + H2O = D-maltotrionate + H(+)
REACT:R-RNO-1602458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP10 (Rattus norvegicus)
REACT:R-SSC-8931653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Sus scrofa)
REACT:R-HSA-9613666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-PLINs translocate from lipid droplet surface to cytosol (Homo sapiens)
REACT:R-XTR-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)
REACT:R-MMU-196857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK2 phosphorylates PanK (Mus musculus)
REACT:R-RNO-6805399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAF1 phosphorylates TP53 (Rattus norvegicus)
REACT:R-BTA-6806732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface (Bos taurus)
REACT:R-HSA-5668414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
RHEA:53407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-DRE-6786048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Danio rerio)
REACT:R-GGA-6807229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)
REACT:R-HSA-8950740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX dissociates from IL12A:EBI3 (Homo sapiens)
REACT:R-MMU-5696183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC3 deaminates BZAM (Mus musculus)
RHEA:24226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcatechol + CO2 + NADPH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+)
REACT:R-SSC-1592387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin binds elastic fibres (Sus scrofa)
RHEA:46178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + AMP + diphosphate => 2-methylpropanoate + ATP + CoA
GO:0033825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amylase III activity
GO:0033825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharide 4-alpha-D-glucosyltransferase activity
GO:0033825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity
GO:0033825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity
RHEA:29708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-anhydro-N-acetyl-beta-muramate(in) => 1,6-anhydro-N-acetyl-beta-muramate(out)
REACT:R-SPO-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Schizosaccharomyces pombe)
REACT:R-DDI-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Dictyostelium discoideum)
REACT:R-SSC-1793207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses C4S/C6S chains (Sus scrofa)
RHEA:53054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate
GO:0047830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-octopine dehydrogenase activity
GO:0047830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	octopine:NAD oxidoreductase activity
GO:0047830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ODH activity
GO:0047830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	octopine dehydrogenase activity
GO:0047830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-octopine synthase activity
GO:0047830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)
GO:0047830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)
REACT:R-XTR-5684862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Xenopus tropicalis)
RHEA:64835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + benzoyl-CoA <=> 3-hydroxy-benzyl benzoate + CoA
REACT:R-HSA-9669870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regorafenib-resistant KIT mutants do not bind regorafenib (Homo sapiens)
GO:0102972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming)
REACT:R-SSC-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Sus scrofa)
RHEA:35119	skos:prefLabel	"demethoxycurcumin synthase"
RHEA:35119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethoxycurcumin synthase"
RHEA:35119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + demethoxycurcumin
RHEA:35119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + CO2 + 2 CoA
RHEA:47665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) => 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-SSC-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Sus scrofa)
REACT:R-CEL-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
REACT:R-RNO-8874204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3 (Rattus norvegicus)
RHEA:51513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxamate => NH4(+) + oxalate
REACT:R-SSC-9733403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds PCSK9 inhibitors (Sus scrofa)
RHEA:20432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin + S-adenosyl-L-methionine <=> acacetin + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Bos taurus)
REACT:R-XTR-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Xenopus tropicalis)
REACT:R-SSC-390598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Sus scrofa)
GO:0102785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	violaxanthin oxygenase activity
REACT:R-MMU-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Mus musculus)
RHEA:60618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate => N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine
RHEA:11269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cysteine + H2O => H(+) + hydrogen sulfide + NH4(+) + pyruvate
REACT:R-RNO-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Rattus norvegicus)
REACT:R-SPO-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Schizosaccharomyces pombe)
REACT:R-CEL-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Caenorhabditis elegans)
REACT:R-CEL-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Caenorhabditis elegans)
RHEA:29797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in) => ATP(in) + H2O(in) + Zn(2+)(out)
RHEA:19863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16-oxosteroid + H(+) + NADH => a 16alpha-hydroxysteroid + NAD(+)
RHEA:19308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA
RHEA:72982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	didemethylasterriquinone D + dimethylallyl diphosphate <=> asterriquinone C1 + diphosphate
GO:0018678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate 1-monooxygenase activity
GO:0018678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate 1-hydroxylase activity
GO:0018678	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
REACT:R-DME-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Drosophila melanogaster)
RHEA:32025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avermitilol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:24591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-arabinose <=> ADP + D-arabinose 5-phosphate + H(+)
REACT:R-BTA-5687090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6 phosphorylates NCOA3 (Bos taurus)
REACT:R-RNO-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
GO:0001634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pituitary adenylate cyclase-activating peptide receptor activity
GO:0001634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pituitary adenylyl cyclase activating protein receptor activity
GO:0001634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pituitary adenylate cyclase-activating polypeptide receptor activity
GO:0001634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PACAP receptor
GO:0001634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pituitary adenylate cyclase activating protein receptor activity
GO:0001634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pituitary adenylate cyclase activating polypeptide receptor
RHEA:29638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaose + H2O <=> alpha-D-glucose + D-maltotetraose
RHEA:65315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]
GO:0018586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mono-butyltin dioxygenase activity
GO:0018586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBT dioxygenase activity
RHEA:68654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + L-homolanthionine => 2 L-homocysteine
RHEA:13390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]
RHEA:48289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM3 => CMP + ganglioside GD3 + H(+)
RHEA:48517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)
REACT:R-MMU-8941613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)
RHEA:59563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N',N''-triacetylchitotriono-1,5-lactone <=> H(+) + N,N',N''-triacetylchitotrionate
GO:0070008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-type exopeptidase activity
RHEA:44672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
REACT:R-SSC-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Sus scrofa)
REACT:R-BTA-216757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)
RHEA:35155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4,5-dihydroxypentane-2,3-dione = (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one
REACT:R-CFA-8948224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)
REACT:R-DME-6805785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates PHF20 (Drosophila melanogaster)
REACT:R-DRE-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Danio rerio)
RHEA:19830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + O2 => an aldehyde + H2O2
RHEA:50794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldosterone + 2 H2O + 2 oxidized [adrenodoxin] => 18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-XTR-5684865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB dimer,C translocate from multivesicle body to lamellar body (Xenopus tropicalis)
RHEA:32961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-isoleucine + NAD(+)
REACT:R-SSC-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)
REACT:R-DRE-4088024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Danio rerio)
REACT:R-CFA-3788725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C complex binds EHMT1:EHMT2 (Canis familiaris)
REACT:R-GGA-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Gallus gallus)
REACT:R-DRE-141409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mad1 binds kinetochore (Danio rerio)
RHEA:69866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in mRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:68854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,6S,7R)-sesquipiperitol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-RNO-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Rattus norvegicus)
REACT:R-MMU-5685649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPAs translocate from ER membrane to extracellular region (Mus musculus)
REACT:R-SSC-209765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)
RHEA:59805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine => D-phenylalanine
RHEA:65396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)
RHEA:35425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose
REACT:R-HSA-73892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGMT/hAGT mediated DNA Damage Reversal (Homo sapiens)
RHEA:63622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + dodecanoyl-[ACP] => ATP + dodecanoate + holo-[ACP]
REACT:R-XTR-5635855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Xenopus tropicalis)
RHEA:23242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate
REACT:R-SSC-6783524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM,LIF,CTF1 receptor complex binds gp130 (Sus scrofa)
RHEA:21290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + glycerol => D-glucose + sn-glycerol 3-phosphate
REACT:R-DRE-3000348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates SP100 with SUMO2 (Danio rerio)
REACT:R-SSC-1638032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Sus scrofa)
REACT:R-GGA-9700662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Gallus gallus)
REACT:R-XTR-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Xenopus tropicalis)
RHEA:43570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-L-galactonate + 2 H(+) + NADH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+)
RHEA:66073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine
RHEA:62562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-perillyl alcohol + AH2 => (4R)-limonene + A + H2O
RHEA:46498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in)
REACT:R-BTA-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Bos taurus)
REACT:R-DRE-174739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant + apoE => chylomicron remnant:apoE complex (Danio rerio)
RHEA:68016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl phosphate + H2O = (2E,6E,10E)-geranylgeraniol + phosphate
REACT:R-SSC-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Sus scrofa)
GO:0103068	skos:altLabel	"gamma-glutamyl transpeptidase"
GO:0103068	skos:altLabel	"glutamyl transpeptidase"
GO:0103068	skos:prefLabel	"gamma-glutamyltransferase"
GO:0103068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]
GO:0103068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-glutamyltransferase"
GO:0103068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene C4 gamma-glutamyl transferase activity
GO:0103068	skos:altLabel	"gamma-glutamyltranspeptidase"
REACT:R-BTA-193073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Bos taurus)
REACT:R-DRE-6786205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Danio rerio)
RHEA:68962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine => 7,8-dihydroxycoumarin + S-adenosyl-L-methionine
REACT:R-SSC-388817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICOS binds ICOSL/B7-H2 (Sus scrofa)
RHEA:46728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2
RHEA:68809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-alpha-D-glucopyranosyl-D-fructose + H2O => alpha-D-glucose + D-fructose
RHEA:72809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(in) => L-histidine(out)
REACT:R-HSA-451056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Microtubule-independent trafficking of connexons to the plasma membrane (Homo sapiens)
RHEA:48448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine
RHEA:69026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N-dihydroxy-L-aspartate + NADP(+) => H(+) + N-hydroxy-L-aspartate + NADPH + O2
RHEA:50624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)
REACT:R-DME-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Drosophila melanogaster)
REACT:R-MMU-400092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Mus musculus)
REACT:R-RNO-141156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)
RHEA:47272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O
REACT:R-PFA-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Plasmodium falciparum)
REACT:R-BTA-5607731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)
GO:0003850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-deoxy-D-glucose-6-phosphate phosphohydrolase activity
GO:0003850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-deoxyglucose-6-phosphate phosphatase activity
GO:0003850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxyglucose-6-phosphatase activity
REACT:R-CFA-1433508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC alpha interacts with and phosphorylates KIT (Canis familiaris)
REACT:R-CEL-917891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Caenorhabditis elegans)
RHEA:63995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-fluorocytidine + ATP <=> 5-fluorocytidine 5'-phosphate + ADP + H(+)
RHEA:43611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O <=> 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate
RHEA:70956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-glutamate(in) => H(+)(out) + L-glutamate(out)
RHEA:31157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-L-glutamate + H(+) + NADH => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+)
RHEA:13493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH
REACT:R-MMU-5654224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds PLCG1 (Mus musculus)
REACT:R-BTA-73932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resynthesis of excised residue by POLB (Bos taurus)
RHEA:65914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine => 3-hydroxy-L-kynurenine + pyruvate
REACT:R-HSA-9712085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK mutants phosphorylate STAT3 (Homo sapiens)
REACT:R-CFA-9021170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen stimulates dimerization of plasma membrane estrogen receptors (Canis familiaris)
REACT:R-SSC-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Sus scrofa)
RHEA:13869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prephenate dehydrogenase"
RHEA:13869	skos:altLabel	"chorismate mutase--prephenate dehydrogenase"
RHEA:13869	skos:altLabel	"hydroxyphenylpyruvate synthase"
RHEA:13869	skos:prefLabel	"prephenate dehydrogenase"
RHEA:13869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH
GO:0052927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:tRNA cytidylyltransferase activity
GO:0052927	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:3'-cytidine-tRNA cytidylyltransferase activity
REACT:R-DME-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Drosophila melanogaster)
REACT:R-XTR-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Xenopus tropicalis)
REACT:R-GGA-2187358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters unphosphorylated SMAD2/3 (Gallus gallus)
RHEA:66589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 26S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-6809264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Homo sapiens)
RHEA:56120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)
REACT:R-SSC-202478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction and oligomerization of MALT1 to Bcl10 (Sus scrofa)
REACT:R-DRE-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Danio rerio)
REACT:R-HSA-2162092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir monophosphate + ATP => carbovir diphosphate + ADP (Homo sapiens)
REACT:R-SSC-1358789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Self-ubiquitination of RNF41 (Sus scrofa)
EC:4.99.1.1	skos:altLabel	"ferrochelatase"
EC:4.99.1.1	skos:altLabel	"protoheme ferro-lyase"
EC:4.99.1.1	skos:altLabel	"iron chelatase"
EC:4.99.1.1	skos:altLabel	"heme synthase"
EC:4.99.1.1	skos:prefLabel	"protoporphyrin ferrochelatase"
EC:4.99.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protoporphyrin ferrochelatase"
REACT:R-CFA-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Canis familiaris)
RHEA:29098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+)(in) + NADH + ubiquinone-8 <=> 4 H(+)(out) + NAD(+) + ubiquinol-8
REACT:R-HSA-1791134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SHC1 (Homo sapiens)
RHEA:41836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-HSA-9624526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Homo sapiens)
REACT:R-MMU-373741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK2 homophillic interaction (Mus musculus)
REACT:R-DRE-377643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of inactive SRC by PTPB1 (Danio rerio)
RHEA:42967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(54/55) in tRNA <=> pseudouridine(54/55) in tRNA
RHEA:44087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + heptadecanoate <=> AMP + diphosphate + heptadecanoyl-CoA
REACT:R-HSA-164500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conformational changes in gp120 exposes gp41 (Homo sapiens)
RHEA:20887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH + NH4(+)
RHEA:44339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + ATP + L-arginine <=> ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate
RHEA:45991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 <=> 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O
RHEA:62937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-acetyl-2'-deoxycytidine => 2'-deoxycytidine + acetate + H(+)
REACT:R-SSC-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Sus scrofa)
REACT:R-SSC-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Sus scrofa)
REACT:R-PFA-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Plasmodium falciparum)
RHEA:12411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NAD(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)
REACT:R-HSA-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Homo sapiens)
RHEA:11134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + protochlorophyllide a => chlorophyllide a + NADP(+)
RHEA:19269	skos:prefLabel	"2-furoate--CoA ligase"
RHEA:19269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate
RHEA:19269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-furoate--CoA ligase"
REACT:R-BTA-4608855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRICKLE1 is degraded by the proteasome (Bos taurus)
REACT:R-HSA-5617881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB4 mRNA is translated (Homo sapiens)
REACT:R-DRE-8938121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds CTSK (Danio rerio)
REACT:R-DME-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Drosophila melanogaster)
GO:0047880	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-erythrulose reductase activity
GO:0047880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythrulose reductase activity
GO:0047880	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythritol:NADP+ oxidoreductase activity
REACT:R-DME-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Drosophila melanogaster)
RHEA:13589	skos:altLabel	"beta-methylcrotonyl-CoA carboxylase"
RHEA:13589	skos:altLabel	"methylcrotonyl-CoA carboxylase"
RHEA:13589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate
RHEA:13589	skos:prefLabel	"methylcrotonoyl-CoA carboxylase"
RHEA:13589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylcrotonoyl-CoA carboxylase"
REACT:R-XTR-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:58237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]
REACT:R-CFA-3249378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING recruits TBK1 and STAT6 (Canis familiaris)
RHEA:48388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
REACT:R-RNO-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Rattus norvegicus)
REACT:R-HSA-9684323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3CLp forms a homodimer (Homo sapiens)
RHEA:70730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O <=> 6-sulfo-alpha-D-quinovose + glycerol
REACT:R-SSC-209063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Sus scrofa)
REACT:R-SSC-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Sus scrofa)
RHEA:21263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (R)-S-oxide
REACT:R-BTA-8864036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates PDGFRB at Y1021 (Bos taurus)
RHEA:67561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + taurocholate => adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate
REACT:R-SSC-2730959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN7:OSTM1 exchanges Cl- for H+ (Sus scrofa)
REACT:R-CFA-447252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB1:TYK2 binds IL12RB2:JAK2 (Canis familiaris)
REACT:R-DRE-193452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Danio rerio)
REACT:R-CEL-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Caenorhabditis elegans)
RHEA:57469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + UDP-alpha-D-glucose => 1-O-[(E)-feruloyl]-beta-D-glucose + UDP
REACT:R-SSC-429798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Sus scrofa)
REACT:R-SSC-1564169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VIII degradation by MMP1 (Sus scrofa)
RHEA:12629	skos:altLabel	"hyoscyamine 6beta-hydroxylase"
RHEA:12629	skos:prefLabel	"hyoscyamine (6S)-dioxygenase"
RHEA:12629	skos:altLabel	"hyoscyamine (6S)-hydroxylase"
RHEA:12629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate
RHEA:12629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hyoscyamine (6S)-dioxygenase"
GO:0050279	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sepiapterin aminohydrolase activity
GO:0050279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sepiapterin deaminase activity
REACT:R-BTA-8964246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in G alpha (12)-BTK complex is activated (Bos taurus)
REACT:R-BTA-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Bos taurus)
REACT:R-HSA-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Homo sapiens)
RHEA:71023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L-phenylalanine(in)
REACT:R-SSC-419001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Sus scrofa)
RHEA:60664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH = NADH + phosphate
REACT:R-CFA-8855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR:DAB1 binds SH3KBP1 (Canis familiaris)
REACT:R-CFA-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Canis familiaris)
REACT:R-RNO-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Rattus norvegicus)
REACT:R-XTR-1475022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (cytosol) (Xenopus tropicalis)
REACT:R-CFA-163809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)
RHEA:52180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Sus scrofa)
GO:0009028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylic carbo-ligase activity
GO:0009028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tartronic semialdehyde carboxylase activity
GO:0009028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymalonic semialdehyde carboxylase activity
GO:0009028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tartronate-semialdehyde synthase activity
GO:0009028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)
GO:0009028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate carboxy-lyase (dimerizing)
GO:0009028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tartronate semialdehyde carboxylase activity
GO:0009028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxalate carboligase activity
GO:0009028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate carboligase activity
GO:0009028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate carbo-ligase activity
RHEA:14384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanal + H2O + NAD(+) <=> 4-guanidinobutanoate + 2 H(+) + NADH
RHEA:52969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyocholate + UDP-alpha-D-glucuronate => H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP
RHEA:44172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + tetradecanal = 2 H(+) + NADH + tetradecanoate
RHEA:35722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-versiconol acetate + H2O <=> (S)-versiconol + acetate + H(+)
REACT:R-BTA-202731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM3 dimerises (Bos taurus)
REACT:R-DRE-83788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to Type 2 promoter (Danio rerio)
REACT:R-PFA-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Plasmodium falciparum)
RHEA:55106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyheptanoyl-[ACP] + NADP(+) => 3-oxoheptanoyl-[ACP] + H(+) + NADPH
RHEA:38514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)
REACT:R-BTA-418874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of N-WASP by Cdc42 (Bos taurus)
REACT:R-MMU-2730856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Mus musculus)
REACT:R-BTA-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Bos taurus)
REACT:R-HSA-216068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with Tenascin-C (Homo sapiens)
REACT:R-BTA-2197646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1 (SR-BI, CLA-1) binds ligands (Bos taurus)
REACT:R-MMU-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Mus musculus)
RHEA:72214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isoborneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH
RHEA:38420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate
REACT:R-SCE-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Saccharomyces cerevisiae)
REACT:R-MMU-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Mus musculus)
REACT:R-DRE-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Danio rerio)
REACT:R-BTA-8866405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)
REACT:R-DME-390154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS (Drosophila melanogaster)
RHEA:16605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"decylcitrate synthase"
RHEA:16605	skos:altLabel	"2-decylcitrate synthase"
RHEA:16605	skos:altLabel	"(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)"
RHEA:16605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)
RHEA:16605	skos:prefLabel	"decylcitrate synthase"
REACT:R-HSA-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Homo sapiens)
REACT:R-SPO-9696275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds GTP (Schizosaccharomyces pombe)
RHEA:64551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] <=> (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]
RHEA:31549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + 2 diphosphate => 2 (2E,6E)-farnesyl diphosphate
RHEA:33805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-histidine + NADH => H2O + L-histidinal + NAD(+)
REACT:R-HSA-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Homo sapiens)
RHEA:32314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-8867754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)
RHEA:64369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2
REACT:R-DRE-201603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of PKC theta (Danio rerio)
REACT:R-HSA-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Homo sapiens)
REACT:R-HSA-389986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Homo sapiens)
RHEA:57624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:36237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA
RHEA:33578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphophytoceramide + beta-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + H2O
REACT:R-RNO-8850326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds self-lipid-based antigen via CD1 (Rattus norvegicus)
RHEA:29773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + arsenate(out) + H(+) + phosphate => arsenate(in) + ATP + H2O
RHEA:39563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)
RHEA:69818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone
REACT:R-HSA-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Homo sapiens)
REACT:R-BTA-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Bos taurus)
REACT:R-HSA-141186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)
GO:0080098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine(histidine) transaminase"
GO:0080098	skos:prefLabel	"phenylalanine(histidine) transaminase"
GO:0080098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + pyruvate = 3-phenylpyruvate + L-alanine
GO:0080098	skos:altLabel	"phenylalanine(histidine) aminotransferase"
GO:0080098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine:pyruvate aminotransferase activity
REACT:R-HSA-8940100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates VCPIP1 (Homo sapiens)
REACT:R-CEL-171087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR [endosome membrane] => LDLR [plasma membrane] (Caenorhabditis elegans)
REACT:R-SSC-170861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimeric TGF-beta-1 binds to the receptor (Sus scrofa)
RHEA:10941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (4R)-limonene + diphosphate
RHEA:50280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate
REACT:R-HSA-9008076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWP1 polyubiquitinates RUNX2 (Homo sapiens)
RHEA:20023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amidinoproclavaminate + CO2 + succinate => 2-oxoglutarate + deoxyamidinoproclavaminate + O2
RHEA:31380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyrrole-2-carboxylate => 1H-pyrrole + hydrogencarbonate
REACT:R-BTA-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Bos taurus)
REACT:R-RNO-158609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers CH3 from AdoMet to 6MP (Rattus norvegicus)
RHEA:52108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
RHEA:52666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain (2E)-enoyl-CoA + H2O => a short-chain (3S)-3-hydroxyacyl-CoA
REACT:R-HSA-5693533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C (ARTEMIS) processes DNA DSB ends (Homo sapiens)
REACT:R-SSC-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Sus scrofa)
REACT:R-BTA-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Bos taurus)
REACT:R-BTA-1676149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)
RHEA:43939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-ene-3,17-dione <=> androst-4-ene-3,17-dione
REACT:R-XTR-1889981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Xenopus tropicalis)
REACT:R-GGA-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Gallus gallus)
REACT:R-SCE-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Saccharomyces cerevisiae)
REACT:R-PFA-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Plasmodium falciparum)
RHEA:22823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:71089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-sulfate(in) + 2 Na(+)(in) => 17beta-estradiol 3-sulfate(out) + 2 Na(+)(out)
REACT:R-SSC-5654709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
RHEA:69850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in RNA + NADP(+) <=> a uridine in RNA + H(+) + NADPH
RHEA:55928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-873927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of STAT1 dimer from active receptor unit (Gallus gallus)
REACT:R-GGA-1297333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Acrosin Heavy and Light Chain (Gallus gallus)
REACT:R-MMU-5666197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds LIN7B (Mus musculus)
REACT:R-MMU-9033509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5L (Mus musculus)
REACT:R-RNO-110355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MUTYH glycosylase by APEX1 at the AP site (Rattus norvegicus)
REACT:R-DRE-5624948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF17 enters the cilium (Danio rerio)
REACT:R-SSC-5610735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB binds ITCH (Sus scrofa)
REACT:R-MMU-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Mus musculus)
RHEA:39017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanedioate + 2 H(+) + NADH => 22-oxodocosanoate + H2O + NAD(+)
REACT:R-DRE-5625426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde IFT (Danio rerio)
RHEA:47012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-disulfide + H(+) + hydrogen sulfide = [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine
RHEA:14665	skos:prefLabel	"guanine deaminase"
RHEA:14665	skos:altLabel	"guanine aminase"
RHEA:14665	skos:altLabel	"GAH"
RHEA:14665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanine deaminase"
RHEA:14665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine + H(+) + H2O = NH4(+) + xanthine
RHEA:14665	skos:altLabel	"guanase"
RHEA:68031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,8-dihydroxypurine + H2O + O2 <=> H2O2 + urate
REACT:R-DDI-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)
RHEA:39719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate = 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)
RHEA:65509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 => H2O2 + NH4(+) + pre-mycofactocin
RHEA:40373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP
RHEA:42958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(38) in tRNA + S-adenosyl-L-methionine
REACT:R-BTA-444171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR2 binds carboxylates (Bos taurus)
REACT:R-MMU-111751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)
RHEA:66196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + tryptamine = CoA + H(+) + N-acetyltryptamine
GO:0016835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-oxygen lyase activity
GO:0016835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carbon-oxygen lyases"
GO:0016835	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	other carbon-oxygen lyase activity
GO:0016835	skos:prefLabel	"Carbon-oxygen lyases"
RHEA:60235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate
RHEA:47262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]
RHEA:55584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:55584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mRNA m(6)A methyltransferase"
RHEA:55584	skos:prefLabel	"mRNA m(6)A methyltransferase"
RHEA:56620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O = 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)
RHEA:69457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH => 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)
REACT:R-DRE-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Danio rerio)
RHEA:51625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + GTP + H(+) => CO2 + dGTP + H2O
REACT:R-HSA-198941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCAM1 binds Integrin alpha4beta1 (Homo sapiens)
REACT:R-MMU-77585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Mus musculus)
REACT:R-MMU-6805546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I binds keratin type II (Mus musculus)
RHEA:37900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 => 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate
REACT:R-SPO-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Schizosaccharomyces pombe)
RHEA:55711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) <=> [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide
REACT:R-RNO-264997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cysteine to cystine in Proinsulin (Rattus norvegicus)
GO:0050295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steryl-beta-glucosidase activity
GO:0050295	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesteryl-beta-D-glucoside glucohydrolase activity
GO:0050295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steryl-b-glucosidase activity
REACT:R-MMU-174448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex on the C-strand of the telomere (Mus musculus)
RHEA:12894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 => prostaglandin E2
GO:0047869	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desulfhydrase activity
GO:0047869	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity
GO:0047869	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)
GO:0047869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylpropiothetin dethiomethylase activity
REACT:R-DRE-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Danio rerio)
RHEA:41412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-DME-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Drosophila melanogaster)
REACT:R-BTA-193054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cholesterol to 22beta-hydroxycholesterol (Bos taurus)
RHEA:39687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-(11Z)-octadecenoyl-CoA = (2E,11Z)-octadecadienoyl-CoA + H2O
REACT:R-HSA-9612639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRG2-activated ERBB4 binds GABA receptors through GABRA1 (Homo sapiens)
RHEA:57343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine
RHEA:45843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydecanoyl-CoA + NADP(+) <=> 3-oxodecanoyl-CoA + H(+) + NADPH
RHEA:62027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesteryl 3-beta-D-glucoside + H2O <=> campesterol + D-glucose
REACT:R-MMU-4420083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Mus musculus)
RHEA:24178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-381135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Bos taurus)
RHEA:38375	skos:altLabel	"C50 carotenoid 2'',3''-hydratase"
RHEA:38375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacterioruberin = bisanhydrobacterioruberin + 2 H2O
RHEA:38375	skos:prefLabel	"bisanhydrobacterioruberin hydratase"
RHEA:38375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bisanhydrobacterioruberin hydratase"
REACT:R-SSC-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Sus scrofa)
RHEA:35072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol(in) => 4-methylphenol(out)
REACT:R-DME-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Drosophila melanogaster)
RHEA:59217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + H(+) => CO2 + skatole
RHEA:16829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2
RHEA:24360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sirohydrochlorin ferrochelatase"
RHEA:24360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + siroheme = Fe(2+) + sirohydrochlorin
RHEA:24360	skos:prefLabel	"sirohydrochlorin ferrochelatase"
GO:0038023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling receptor activity
GO:0038023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signalling receptor activity
GO:0038023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor activity involved in signal transduction
GO:0038023	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	receptor activity
REACT:R-SPO-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Schizosaccharomyces pombe)
REACT:R-CEL-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Caenorhabditis elegans)
REACT:R-XTR-5336184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37L binds prosaposin (Xenopus tropicalis)
REACT:R-XTR-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Xenopus tropicalis)
REACT:R-SCE-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Saccharomyces cerevisiae)
REACT:R-HSA-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)
REACT:R-HSA-176700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)
REACT:R-SSC-2130486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoating of clathrin-coated vesicles and fusion with endosomes (Sus scrofa)
REACT:R-RNO-373087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR6 binds CCL20 ligand (Rattus norvegicus)
RHEA:72121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + glycine betaine(in) => (R)-carnitine(in) + glycine betaine(out)
REACT:R-HSA-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Homo sapiens)
GO:0048018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling molecule
GO:0048018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor ligand activity
GO:0048018	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	receptor agonist activity
GO:0048018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin D receptor activator activity
GO:0048018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling receptor ligand activity
REACT:R-DRE-751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gz complex dissociates (Danio rerio)
RHEA:59759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine
REACT:R-HSA-9712086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK fusions phosphorylate PLCG1 (Homo sapiens)
RHEA:56033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)
REACT:R-CFA-6805059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2:FACT phosphorylates TP53 (Canis familiaris)
REACT:R-HSA-170844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 is cleaved by FURIN (Homo sapiens)
REACT:R-XTR-5660665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 binds MALT (Xenopus tropicalis)
REACT:R-DDI-2514772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Dictyostelium discoideum)
GO:0047180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salutaridinol 7-O-acetyltransferase activity
GO:0047180	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:salutaridinol 7-O-acetyltransferase activity
REACT:R-BTA-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Bos taurus)
RHEA:67009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine
REACT:R-BTA-265296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Bos taurus)
REACT:R-MMU-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Mus musculus)
RHEA:39599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)
RHEA:59628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(4-aminobutanoyl)-L-arginine = 4-aminobutanoate + L-arginine
GO:0102739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity
RHEA:24700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A
REACT:R-CFA-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)
REACT:R-RNO-2187325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)
RHEA:12609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mercaptopurine + S-adenosyl-L-methionine = 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-445752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Canis familiaris)
RHEA:72748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene E4(out) => leukotriene E4(in)
REACT:R-RNO-264689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Rattus norvegicus)
REACT:R-HSA-5578777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMPK phosphorylates PLN (Homo sapiens)
RHEA:57059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apiofuranose + NAD(+) <=> D-apionolactone + H(+) + NADH
RHEA:28233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9624017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SHC1 binds integrin alpha5beta1:fibronectin (Mus musculus)
REACT:R-PFA-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Plasmodium falciparum)
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type DNA binding transcription repressor activity
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-binding transcription repressor activity
GO:0001217	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
REACT:R-DRE-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Danio rerio)
RHEA:37504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-HSA-6803437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates ZNF385A transcription (Homo sapiens)
RHEA:18298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phtalamide + H2O => a primary amine + phthalate
RHEA:60688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) = (11R)-dihydroartemisinate + 2 H(+) + NADH
RHEA:50176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate
RHEA:55955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)
REACT:R-CFA-349455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MDM4 by ATM (Canis familiaris)
REACT:R-SCE-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Saccharomyces cerevisiae)
REACT:R-BTA-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Bos taurus)
GO:0102542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin A methylesterase activity
RHEA:39069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hexanedioyl-CoA => 3-oxooctanedioyl-CoA + CoA
RHEA:61266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NH4(+) + pyruvate => H2O + L-alanine + O2
RHEA:44000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 = 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate
REACT:R-XTR-5635843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI translocates to the nucleus (Xenopus tropicalis)
REACT:R-SSC-9696275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds GTP (Sus scrofa)
REACT:R-CFA-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Canis familiaris)
REACT:R-DRE-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Danio rerio)
RHEA:60665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH => NADH + phosphate
RHEA:43347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) <=> [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-HSA-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Homo sapiens)
REACT:R-GGA-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Gallus gallus)
RHEA:36159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]
GO:0043920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(1)-aminopropylagmatine ureohydrolase"
GO:0043920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminopropylagmatine ureohydrolase activity
GO:0043920	skos:prefLabel	"N(1)-aminopropylagmatine ureohydrolase"
GO:0043920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-aminopropylagmatine = spermidine + urea
RHEA:71712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-tyrosylglycine(out) => H(+)(in) + L-tyrosylglycine(in)
REACT:R-DME-8935732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds SIN3A,(SIN3B) co-repressor (Drosophila melanogaster)
REACT:R-MMU-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Mus musculus)
REACT:R-DRE-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Danio rerio)
GO:0047224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity
GO:0047224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mucin core 3 beta3-GlcNAc-transferase activity
GO:0047224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	core 3beta-GlcNAc-transferase activity
GO:0047224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
GO:0047224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity
GO:0047224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	core 3-beta-GlcNAc-transferase activity
GO:0047224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity
REACT:R-SSC-419003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Nectins with Afadin (Sus scrofa)
RHEA:31117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinyl-5'-AMP + diphosphate => ATP + biotin + H(+)
RHEA:54924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-DDI-2162019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to EXA4 by ALOX15 (Dictyostelium discoideum)
RHEA:22242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(carboxyaminomethyl)urea + NH4(+) => H2O + methylenediurea
RHEA:38064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA => 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
RHEA:69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrotestosterone + H(+) + NADPH <=> 5beta-androstane-3beta,17beta-diol + NADP(+)
REACT:R-RNO-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Rattus norvegicus)
REACT:R-SSC-8851988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A2 binds T cell surface (Sus scrofa)
RHEA:35387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-7 + S-adenosyl-L-methionine = 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine
RHEA:12177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylethanolamine + S-adenosyl-L-methionine => H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine
REACT:R-HSA-114256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS:APAF1 binds procaspase-9 (Homo sapiens)
RHEA:41460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacylglycerol + a sphingomyelin
RHEA:16279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + H(+) + H2O2 => H2O + indole-3-acetaldehyde + O2
RHEA:44063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA
RHEA:64587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate(out) + Na(+)(out) <=> 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)
RHEA:39188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydocosanoyl-CoA => (2E)-docosenoyl-CoA + H2O
REACT:R-DRE-4090408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate ESR1 with SUMO1 (Danio rerio)
RHEA:70694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + glycine(out) + 2 Na(+)(out) <=> chloride(in) + glycine(in) + 2 Na(+)(in)
RHEA:42715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(54) in tRNA <=> 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:17600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + 2 Fe(III)-[cytochrome c] <=> D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)
RHEA:71975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(out) + 3 Na(+)(out) = glutathione(in) + 3 Na(+)(in)
GO:0017103	skos:altLabel	"Gal-1-P uridylyltransferase"
GO:0017103	skos:prefLabel	"UTP--hexose-1-phosphate uridylyltransferase"
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose pyrophosphorylase activity
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Gal-1-P uridylyltransferase activity
GO:0017103	skos:altLabel	"galactose-1-phosphate uridylyltransferase"
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate galactose pyrophosphorylase activity
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose 1-phosphate uridyltransferase activity
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP:galactose-1-phosphate uridylyltransferase activity
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-galactose 1-phosphate uridylyltransferase activity
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP-hexose-1-phosphate uridylyltransferase activity
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-galactose
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	UTP:hexose-1-phosphate uridylyltransferase activity
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UTP--hexose-1-phosphate uridylyltransferase"
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose pyrophosphorylase activity
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose 1-phosphate uridylyltransferase activity
GO:0017103	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	galactose-1-phosphate uridylyltransferase activity
REACT:R-MMU-77331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Mus musculus)
RHEA:41595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)
REACT:R-MMU-8964280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Gq binds BTK (Mus musculus)
REACT:R-SSC-5696021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPGK:Mg2+ phosphorylates Glc to G6P (Sus scrofa)
RHEA:22573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N-methyl-L-glutamate => AH2 + formaldehyde + L-glutamate
GO:0102737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-coumaroyltriacetic acid synthase activity
REACT:R-HSA-174963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1 acetylation (Homo sapiens)
GO:0004641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
GO:0004641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylaminoimidazole synthetase activity
GO:0004641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AIR synthase activity
GO:0004641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl-aminoimidazole synthetase activity
GO:0004641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AIR synthetase activity
GO:0004641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AIRS activity
GO:0004641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0004641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-aminoimidazole ribonucleotide synthetase activity
GO:0004641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
RHEA:31825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
GO:0005131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	growth hormone
GO:0005131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	growth hormone receptor ligand
GO:0005131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth hormone receptor binding
RHEA:36808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + octacosanoyl-CoA => 3-oxo-triacontanoyl-CoA + CO2 + CoA
RHEA:65480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + hexan-1-ol = CoA + hexyl 2-methylbutanoate
RHEA:10637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NADP(+) => D-mannuronate + H(+) + NADPH
RHEA:58072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4,5-didehydrojasmonate + H(+) + NADPH = a jasmonate + NADP(+)
REACT:R-CFA-8865107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MICAL1 produces NADP+, H2O2 (Canis familiaris)
REACT:R-HSA-6798268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 and E2F4 inhibit CDC25C expression (Homo sapiens)
GO:0030410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotianamine synthase activity
GO:0030410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity
REACT:R-CFA-5658435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs bind RAS:GTP (Canis familiaris)
RHEA:42911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(1939) in 23S rRNA <=> 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Sus scrofa)
REACT:R-RNO-8941618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
EC:2.4.1.25	skos:prefLabel	"4-alpha-glucanotransferase"
EC:2.4.1.25	skos:altLabel	"disproportionating enzyme"
EC:2.4.1.25	skos:altLabel	"dextrin glycosyltransferase"
EC:2.4.1.25	skos:altLabel	"oligo-1,4-1,4-glucantransferase"
EC:2.4.1.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-alpha-glucanotransferase"
EC:2.4.1.25	skos:altLabel	"D-enzyme"
GO:0042165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter binding
REACT:R-HSA-2213240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of disulphide bonds in MHC II antigens (Homo sapiens)
REACT:R-CFA-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Canis familiaris)
REACT:R-HSA-879934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)
RHEA:22518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-phosphotaurocyamine => ATP + taurocyamine
RHEA:58373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-oct-2-en-1-ol + NADP(+) => (2E)-octenal + H(+) + NADPH
REACT:R-HSA-5687585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-BTA-159790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Bos taurus)
REACT:R-HSA-1474197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP1,3,8,13,PRSS2 (Homo sapiens)
REACT:R-HSA-5675456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
RHEA:53716	skos:prefLabel	"N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase"
RHEA:53716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase"
RHEA:53716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP = phosphate + UDP-N-acetyl-alpha-D-muramate
REACT:R-DRE-4647593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP400 binds CDKN1A promoter (Danio rerio)
RHEA:62861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 H(+) + 7 malonyl-CoA => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O
REACT:R-MMU-2213210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen IX is cross-linked to the surface of collagen type II fibrils (Mus musculus)
REACT:R-HSA-8952419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs ubiquitinate RUNX3 (Homo sapiens)
RHEA:42500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH
RHEA:39976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminobutanoate + H2O => 2-oxobutanoate + NH4(+)
REACT:R-SPO-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Schizosaccharomyces pombe)
REACT:R-SSC-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Sus scrofa)
RHEA:51614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate + 2-oxoglutarate => (R)-2-hydroxyglutarate + oxaloacetate
RHEA:49944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate = (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate
RHEA:38552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 => (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:19695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+)
REACT:R-SSC-9706315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SH2B3 (Sus scrofa)
REACT:R-SSC-9733960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids dissociate from ALB (Sus scrofa)
REACT:R-XTR-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Xenopus tropicalis)
RHEA:54200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:49270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:39251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH = (11Z)-eicosenoyl-CoA + NADP(+)
REACT:R-MMU-9035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysS248-MPST:TXN2 dissociates (Mus musculus)
RHEA:39226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctacosanoyl-CoA <=> (2E)-octacosenoyl-CoA + H2O
REACT:R-BTA-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Bos taurus)
RHEA:59050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + putrescine => D-ornithine + H(+)
REACT:R-XTR-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)
REACT:R-DME-5607723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Drosophila melanogaster)
RHEA:49019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C epoxide <=> 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one
REACT:R-HSA-2002466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of allysine by LOX (Homo sapiens)
GO:0042799	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H4K20 methylase activity
GO:0042799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4 lysine 20-specific methyltransferase activity
GO:0042799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K20 methyltransferase activity
GO:0042799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-methyltransferase activity (H4-K20 specific)
GO:0042799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H4-K20 specific)
GO:0042799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H4-K20 specific)
GO:0042799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H4K20 methyltransferase activity
RHEA:32214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-5-oxohex-2-enedioate <=> (2E,4Z)-2-hydroxyhexa-2,4-dienedioate
RHEA:70642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:32307	skos:altLabel	"arachidonic acid 5-lipoxygenase"
RHEA:32307	skos:altLabel	"Delta(5)-lipoxygenase"
RHEA:32307	skos:altLabel	"C-5-lipoxygenase"
RHEA:32307	skos:altLabel	"5-lipoxygenase"
RHEA:32307	skos:altLabel	"arachidonic 5-lipoxygenase"
RHEA:32307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arachidonate 5-lipoxygenase"
RHEA:32307	skos:altLabel	"leukotriene-A4 synthase"
RHEA:32307	skos:altLabel	"5Delta-lipoxygenase"
RHEA:32307	skos:altLabel	"LTA synthase"
RHEA:32307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4
RHEA:32307	skos:prefLabel	"arachidonate 5-lipoxygenase"
REACT:R-CFA-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)
REACT:R-DDI-8957389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Dictyostelium discoideum)
RHEA:31192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O
REACT:R-HSA-2022063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)
REACT:R-RNO-9033949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Rattus norvegicus)
RHEA:48528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GP1c (d18:1(4E)) + H2O = ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate
REACT:R-HSA-192916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of vRNA Synthesis (Homo sapiens)
REACT:R-SSC-8863804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Sus scrofa)
REACT:R-DRE-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Danio rerio)
REACT:R-CFA-159826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Canis familiaris)
RHEA:47288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Danio rerio)
REACT:R-RNO-5226904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Rattus norvegicus)
RHEA:33563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + ATP = (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)
REACT:R-MMU-1482892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Mus musculus)
REACT:R-HSA-1368065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of NPAS2 (Homo sapiens)
GO:0033848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2-(2-carboxyethyl)arginine synthase activity
GO:0033848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity
GO:0033848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2-(2-carboxyethyl)arginine synthetase activity
GO:0033848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity
GO:0033848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CEA synthetase activity
GO:0033848	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CEAS
RHEA:36152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamyl alcohol + acetyl-CoA => (E)-cinnamyl acetate + CoA
RHEA:68247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(in) + Na(+)(in) <=> L-phenylalanine(out) + Na(+)(out)
REACT:R-MMU-9718020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PTGFR agonists (Mus musculus)
RHEA:47854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O
RHEA:47046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnitine + acetyl-CoA
RHEA:45972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)
RHEA:48259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-BTA-193691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kB migrates to the nucleus and turns on transcription (Bos taurus)
REACT:R-XTR-9748983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)
RHEA:61854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesteryl 3-beta-D-glucoside + H(+) + UDP => campesterol + UDP-alpha-D-glucose
RHEA:17458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein]-L-cysteine + L-cysteine => [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine
GO:0016673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With an iron-sulfur protein as acceptor"
GO:0016673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor
GO:0016673	skos:prefLabel	"With an iron-sulfur protein as acceptor"
GO:0016673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor
RHEA:61908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol = 2 AMP + asperphenamate + 2 diphosphate + H(+)
REACT:R-DDI-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Dictyostelium discoideum)
REACT:R-MMU-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Mus musculus)
REACT:R-BTA-75090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR1 homodimer to dsRNA duplex (Bos taurus)
REACT:R-GGA-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Gallus gallus)
EC:2.4.2.30	skos:altLabel	"poly(ADP-ribose) synthetase"
EC:2.4.2.30	skos:altLabel	"poly(adenosine diphosphate ribose) polymerase"
EC:2.4.2.30	skos:prefLabel	"NAD(+) ADP-ribosyltransferase"
EC:2.4.2.30	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(+) ADP-ribosyltransferase"
EC:2.4.2.30	skos:altLabel	"poly(ADP-ribose)polymerase"
EC:2.4.2.30	skos:altLabel	"ADP-ribosyltransferase (polymerizing)"
REACT:R-HSA-9013990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA (Homo sapiens)
REACT:R-HSA-9664406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgG:Lma antigens binds FCGR3A:CD3 dimers (Homo sapiens)
REACT:R-CFA-450551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 binds translation and heat shock proteins (Canis familiaris)
GO:0031728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR3 chemokine receptor binding
GO:0031728	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR3 chemokine receptor ligand
GO:0031728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eosinophil eotaxin receptor binding
REACT:R-RNO-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Rattus norvegicus)
REACT:R-RNO-2327733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 binds Collagen types I-V, VII (Rattus norvegicus)
REACT:R-MMU-9026007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Mus musculus)
REACT:R-SSC-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Sus scrofa)
RHEA:23773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => 2,3-dihydroxy-p-cumate + H(+) + NADH
REACT:R-RNO-4332356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK2 binds MAP3K7 (Rattus norvegicus)
REACT:R-XTR-8857925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Xenopus tropicalis)
RHEA:59845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl alcohol + H(+) + NADPH => (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)
REACT:R-SCE-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Saccharomyces cerevisiae)
REACT:R-SSC-936802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to extracellular region (Sus scrofa)
RHEA:66549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 4-nitrophenol => 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate
REACT:R-DRE-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Danio rerio)
REACT:R-SSC-8853801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPN binds RET:GFRA4 (Sus scrofa)
GO:0050121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylglucosamine 2-epimerase activity
GO:0050121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcNAc 2-epimerase activity
GO:0050121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-D-glucosamine 2-epimerase activity
GO:0050121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-glucosamine 2-epimerase activity
GO:0050121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylglucosamine 2-epimerase activity
GO:0050121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosamine 2-epimerase activity
GO:0050121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Homo sapiens)
RHEA:37046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-glutamate(out) <=> ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate
RHEA:11170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH => 3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+)
REACT:R-MMU-8981534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin dimer:KIRREL binds FYN (Mus musculus)
REACT:R-DDI-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Dictyostelium discoideum)
EC:3.4.17.8	skos:altLabel	"D-alanine-D-alanine-carboxypeptidase"
EC:3.4.17.8	skos:altLabel	"DD-peptidase"
EC:3.4.17.8	skos:altLabel	"UDP-N-acetylmuramoyl-tetrapeptidyl-D-alanine alanine-hydrolase"
EC:3.4.17.8	skos:altLabel	"D-alanyl-D-alanine carboxypeptidase"
EC:3.4.17.8	skos:altLabel	"D-alanyl-D-alanine peptidase"
EC:3.4.17.8	skos:altLabel	"PBP5"
EC:3.4.17.8	skos:altLabel	"D-alanine carboxypeptidase"
EC:3.4.17.8	skos:altLabel	"DD-carboxypeptidase"
EC:3.4.17.8	skos:prefLabel	"muramoylpentapeptide carboxypeptidase"
EC:3.4.17.8	skos:altLabel	"carboxypeptidase D-alanyl-D-alanine"
EC:3.4.17.8	skos:altLabel	"penicillin binding protein 5"
EC:3.4.17.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"muramoylpentapeptide carboxypeptidase"
RHEA:59187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetylphloroglucinol + H2O <=> 2-acetylphloroglucinol + acetate
REACT:R-MMU-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Mus musculus)
REACT:R-SSC-429581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 transports vitamins from extracellular region to cytosol (Sus scrofa)
RHEA:39026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-3322019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-b (Canis familiaris)
REACT:R-SCE-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Saccharomyces cerevisiae)
GO:0008311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
GO:0008311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded DNA 3'-5' exodeoxyribonuclease activity
REACT:R-HSA-9665407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
REACT:R-CFA-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Canis familiaris)
RHEA:20310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => 2 H2O + O2
RHEA:35122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O <=> bisdemethoxycurcumin + CO2 + 2 CoA
RHEA:49314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-(+)-abscisic aldehyde + H(+) + NADH => 2-trans,4-trans-xanthoxin + NAD(+)
REACT:R-XTR-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Xenopus tropicalis)
REACT:R-BTA-5676595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAFs bind RANK:RANKL (Bos taurus)
REACT:R-XTR-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Xenopus tropicalis)
RHEA:39349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH
RHEA:16120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + ATP + CoA <=> acetoacetyl-CoA + AMP + diphosphate
REACT:R-MMU-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Mus musculus)
REACT:R-CEL-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Caenorhabditis elegans)
REACT:R-GGA-8852324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds PLK1 (Gallus gallus)
RHEA:39056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0008917	skos:prefLabel	"lipopolysaccharide N-acetylglucosaminyltransferase"
GO:0008917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipopolysaccharide N-acetylglucosaminyltransferase"
GO:0008917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity
GO:0008917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide N-acetylglucosaminyltransferase activity
GO:0008917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity
GO:0008917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity
GO:0008917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS N-acetylglucosaminyltransferase activity
REACT:R-CEL-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Caenorhabditis elegans)
REACT:R-GGA-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Gallus gallus)
REACT:R-RNO-9014467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the ER membrane (Rattus norvegicus)
RHEA:57241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + GMP => N(2)-(1-hydroxy-2-oxoethyl)-GMP
RHEA:49072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O
RHEA:49072	skos:prefLabel	"dibenzothiophene monooxygenase"
RHEA:49072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dibenzothiophene monooxygenase"
REACT:R-GGA-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Gallus gallus)
GO:0103023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPase activity
REACT:R-HSA-157849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
RHEA:66986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + isovalerate => 3-methylbutanoyl-CoA + H2O
RHEA:19025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate + O2 = H2O2 + NH4(+) + oxaloacetate
RHEA:20656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23,24-dihydrocucurbitacin B + NAD(+) <=> cucurbitacin B + H(+) + NADH
RHEA:20287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate
REACT:R-DRE-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Danio rerio)
RHEA:72695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)
GO:0102060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-alpha-bergamotene synthase activity
GO:0102060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-alpha-bergamontene synthase activity
GO:0015327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cystine:glutamate antiporter activity
GO:0102937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity
RHEA:51415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate
REACT:R-BTA-873919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Bos taurus)
RHEA:72562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + pentanoate(in) <=> estrone 3-sulfate(in) + pentanoate(out)
REACT:R-GGA-3371467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates HSF1 (Gallus gallus)
RHEA:35639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
EC:1.1.1.302	skos:prefLabel	"2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase"
EC:1.1.1.302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase"
EC:1.1.1.302	skos:altLabel	"2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase"
RHEA:39181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + NADP(+) => (2E)-eicosenoyl-CoA + H(+) + NADPH
REACT:R-DRE-9731613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)
RHEA:31103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydrofolate + NADP(+) = folate + H(+) + NADPH
RHEA:62452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-glutamate = AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]
RHEA:62452	skos:prefLabel	"L-glutamate--[L-glutamyl-carrier protein] ligase"
RHEA:62452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glutamate--[L-glutamyl-carrier protein] ligase"
REACT:R-SSC-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Sus scrofa)
RHEA:39949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + a monoacylglycerol + H(+) => 1,3-diacyl-sn-glycerol + H2O
REACT:R-CEL-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Caenorhabditis elegans)
REACT:R-MMU-8877760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Mus musculus)
RHEA:27903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H2O + ubiquinone-0 => 1,3,7-trimethylurate + ubiquinol-0
RHEA:49035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-9714480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the mitochondrial membrane (Gallus gallus)
REACT:R-MMU-5633040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Mus musculus)
RHEA:51674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + H(+) => glyoxal + H2O
REACT:R-HSA-417927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y2 receptor binds ATP and UTP (Homo sapiens)
GO:0043008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent protein binding
REACT:R-DRE-5692437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANG binds F-actin (Danio rerio)
REACT:R-DME-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Drosophila melanogaster)
REACT:R-DRE-9757954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4BP1 binds IKBKG (Danio rerio)
REACT:R-DME-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Drosophila melanogaster)
RHEA:57496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylcitrate = 2-methyl-cis-aconitate + H2O
GO:0052680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] activity
GO:0052680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epi-isozizaene synthase activity
RHEA:47130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + deoxycholoyl-CoA + diphosphate => ATP + CoA + deoxycholate
RHEA:53473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate
REACT:R-RNO-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Rattus norvegicus)
REACT:R-SSC-416546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Sus scrofa)
REACT:R-CFA-5432814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR2:TLR1 (Canis familiaris)
RHEA:55814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine
REACT:R-MMU-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Mus musculus)
RHEA:57989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP
REACT:R-DME-2028598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS1 (Drosophila melanogaster)
RHEA:35121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisdemethoxycurcumin + CO2 + 2 CoA => (4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O
RHEA:20906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1,2-epoxypropane + coenzyme M => (2S)-2-hydroxypropyl-coenzyme M
REACT:R-SSC-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)
RHEA:50268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
REACT:R-BTA-983194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-1 is a heterotetramer (Bos taurus)
RHEA:30275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"catalase peroxidase"
RHEA:30275	skos:prefLabel	"catalase peroxidase"
RHEA:30275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H2O2 = A + 2 H2O
REACT:R-HSA-5601883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complexed PIWIL4 binds cleaved transposon RNA (Homo sapiens)
RHEA:11169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) => 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH
RHEA:32605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeraniol + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)
RHEA:70005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-965067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THTPA:Mg2+ hydrolyzes ThTP to TDP (Xenopus tropicalis)
RHEA:26520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acryloyl-CoA + H2O => 3-hydroxypropanoyl-CoA
REACT:R-SSC-5660663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 cleaves IL1B precursor (Sus scrofa)
REACT:R-CFA-177944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
REACT:R-RNO-422051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the signal peptide of Preproghrelin (Rattus norvegicus)
REACT:R-SCE-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Saccharomyces cerevisiae)
GO:0070853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin VI binding
RHEA:18928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulono-1,4-lactone + NADP(+) <=> D-glucurono-3,6-lactone + H(+) + NADPH
REACT:R-MMU-174690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Mus musculus)
REACT:R-GGA-182594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of INK4 family proteins with CDK4/6 (Gallus gallus)
RHEA:12860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-methyl-L-aspartate <=> L-glutamate
RHEA:63323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a glycerophospholipid(in) + ATP + H2O <=> a glycerophospholipid(out) + ADP + H(+) + phosphate
REACT:R-RNO-6783670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1 binds CLCF1 (Rattus norvegicus)
RHEA:70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+)
RHEA:47263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) + L-phenylalanine(in)
GO:0106261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine
GO:0106261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA uridine(34) acetyltransferase activity
REACT:R-DRE-6811414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF (Danio rerio)
RHEA:57410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+)
REACT:R-HSA-9024906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDNF binds NTRK2 (TRKB) (Homo sapiens)
GO:0050391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine dehydrogenase (NADP+) activity
GO:0050391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine dehydrogenase (NADP) activity
GO:0050391	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-valine:NADP+ oxidoreductase (deaminating)
GO:0050391	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine dehydrogenase (nicotinanide adenine dinucleotide phosphate)
GO:0034928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxypyrene 6,7-monooxygenase activity
RHEA:42781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine
RHEA:37543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-chlorophenol + O2 = 2-amino-5-chloromuconate 6-semialdehyde
RHEA:37543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-amino-5-chlorophenol 1,6-dioxygenase"
RHEA:37543	skos:prefLabel	"2-amino-5-chlorophenol 1,6-dioxygenase"
REACT:R-SSC-5610758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Sus scrofa)
REACT:R-SSC-877198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates membrane pores that include pannexin-1 (Sus scrofa)
RHEA:20206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylazoxymethanol + UDP-alpha-D-glucose => cycasin + H(+) + UDP
RHEA:14244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4-hydroxybenzaldehyde + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)
REACT:R-SSC-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Sus scrofa)
REACT:R-MMU-139842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Syk tyrosine kinase (Mus musculus)
GO:0102741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity
RHEA:58123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[protein] <=> 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate
REACT:R-XTR-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Xenopus tropicalis)
RHEA:11236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + spermidine = propane-1,3-diamine + sym-homospermidine
RHEA:56298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + S-sulfanyl-L-cysteinyl-[protein] => 2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein]
RHEA:29877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-L-serine
REACT:R-SSC-1678923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR folding by chaperones GP96 and CNPY3 (Sus scrofa)
REACT:R-MMU-211247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DNA by DFF40 (Mus musculus)
RHEA:48331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))
RHEA:23282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + S-acetylcysteamine => acetyl-CoA + cysteamine
REACT:R-GGA-5635741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Gallus gallus)
REACT:R-DRE-3000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BORA binds SCF-beta-TrCp1/2 (Danio rerio)
REACT:R-DME-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Drosophila melanogaster)
RHEA:53791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholoyl-CoA + beta-muricholate <=> allodeoxycholate + beta-muricholoyl-CoA
REACT:R-CFA-9695890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Canis familiaris)
REACT:R-XTR-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Xenopus tropicalis)
REACT:R-HSA-192097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Homo sapiens)
RHEA:34213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecgonone methyl ester + H(+) + NADPH => ecgonine methyl ester + NADP(+)
REACT:R-BTA-443418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b signaling involves c-Src (Bos taurus)
REACT:R-MMU-5250930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH recruits histone acetyltransferases (Mus musculus)
RHEA:33136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(in) + Na(+)(in) => malonate(out) + Na(+)(out)
REACT:R-MMU-4719448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO3 (Mus musculus)
RHEA:30552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + beta-D-glucose => 6-O-acetyl-beta-D-glucose + CoA
RHEA:54571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in rRNA <=> a pseudouridine in rRNA
REACT:R-SSC-389352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Vav1 to CD28 (Sus scrofa)
REACT:R-MMU-6807206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 and OTUD3 deubiquitinate PTEN (Mus musculus)
RHEA:31327	skos:altLabel	"DIPPS"
RHEA:31327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol = bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)
RHEA:31327	skos:prefLabel	"CDP-L-myo-inositol myo-inositolphosphotransferase"
RHEA:31327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-L-myo-inositol myo-inositolphosphotransferase"
RHEA:32403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S,4R)-neodihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH
REACT:R-CFA-4641205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPO:LGR binds ZNRF3 (Canis familiaris)
RHEA:23459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + AH2 + O2 <=> A + crepenynate + 2 H2O
REACT:R-GGA-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Gallus gallus)
REACT:R-CFA-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)
REACT:R-GGA-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Gallus gallus)
REACT:R-RNO-192434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of diacylglycerols by extracellular PTL:colipase (Rattus norvegicus)
GO:0047761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyrate kinase activity
GO:0047761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:butanoate 1-phosphotransferase activity
GO:0031432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	titin binding
REACT:R-CFA-9014420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the phagocytic vesicle membrane (Canis familiaris)
REACT:R-PFA-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Plasmodium falciparum)
REACT:R-DRE-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Danio rerio)
REACT:R-MMU-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Mus musculus)
REACT:R-SCE-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Saccharomyces cerevisiae)
REACT:R-RNO-4551661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates RNF168 with SUMO1 (Rattus norvegicus)
RHEA:10321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O
REACT:R-MMU-8858298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRASLS transfer acyl group from PC to PE to form NAPE (Mus musculus)
RHEA:51984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-8984021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Rattus norvegicus)
GO:0047551	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-ketoaldehyde dehydrogenase activity
GO:0047551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoaldehyde dehydrogenase (NAD+) activity
GO:0047551	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-ketoaldehyde dehydrogenase
GO:0047551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoaldehyde dehydrogenase (NAD+)
GO:0047551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoaldehyde:NAD+ 2-oxidoreductase activity
GO:0047551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked alpha-ketoaldehyde dehydrogenase activity
GO:0047551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent alpha-ketoaldehyde dehydrogenase activity
GO:0047551	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methylglyoxal dehydrogenase activity
REACT:R-BTA-5654148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR3 (Bos taurus)
RHEA:17698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridine + thiamine => 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine
REACT:R-HSA-9604703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds NOTCH4 gene (Homo sapiens)
REACT:R-RNO-72127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal B Complex (Rattus norvegicus)
REACT:R-RNO-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)
RHEA:65694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine
REACT:R-RNO-437230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-FGFR cis-heterodimerization (Rattus norvegicus)
RHEA:25402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate
RHEA:70300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-dehydroascorbate => 2,3-dioxo-L-gulonate
REACT:R-HSA-3928623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind NMDARs (Homo sapiens)
REACT:R-SSC-111751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)
GO:0018776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-chloroacrylic acid dehalogenase activity
RHEA:40304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + AH2
REACT:R-RNO-5694487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A4GNT transfers GlcNAc to core 2 mucins (Rattus norvegicus)
REACT:R-MMU-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Mus musculus)
RHEA:17996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + gamma-L-glutamyl-L-cysteine <=> ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate
RHEA:11075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 3 H(+) + NADPH + O2 <=> catechol + CO2 + NADP(+) + NH4(+)
REACT:R-DRE-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Danio rerio)
RHEA:45520	skos:altLabel	"phycoviolobilin phycoerythrocyanin-alpha84-cystein-lyase"
RHEA:45520	skos:prefLabel	"phycoerythrocyanin alpha-cysteine-84 phycoviolobilin lyase/isomerase"
RHEA:45520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phycoerythrocyanin alpha-cysteine-84 phycoviolobilin lyase/isomerase"
RHEA:45520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]
REACT:R-DDI-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Dictyostelium discoideum)
RHEA:62629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxide + H(+) + NADH => an alcohol + H2O + NAD(+)
REACT:R-CEL-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
RHEA:56403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)
REACT:R-CEL-177942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EGF ligand (Caenorhabditis elegans)
REACT:R-HSA-3304394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)
RHEA:23840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)
RHEA:23840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-carboxyethylcatechol 2,3-dioxygenase"
RHEA:23840	skos:prefLabel	"3-carboxyethylcatechol 2,3-dioxygenase"
RHEA:23840	skos:altLabel	"2,3-dihydroxy-beta-phenylpropionate oxygenase"
RHEA:23840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)
GO:0022841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium ion leak channel activity
RHEA:30248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 4 hnu + 2 plastoquinone-9 => O2 + 2 plastoquinol-9
RHEA:69294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	goitrin + sulfate => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate
REACT:R-GGA-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Gallus gallus)
REACT:R-DME-450222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
REACT:R-SSC-6785898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R binds JAK2 (Sus scrofa)
RHEA:59281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine => D-asparagine
GO:0004888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelinase is activated by the NGF:p75NTR complex (Homo sapiens)
GO:0004888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane signaling receptor activity
GO:0004888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane signalling receptor activity
GO:0004888	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transmembrane receptor activity
GO:0047191	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity
GO:0047191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkylglycerophosphocholine O-acyltransferase activity
RHEA:25307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin + phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O
RHEA:24030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine + CO2 + succinate => 2-oxoglutarate + 4-(trimethylamino)butanoate + O2
RHEA:44121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + octadecan-1-ol => CoA + octadecanyl hexadecanoate
REACT:R-BTA-109822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Bos taurus)
REACT:R-GGA-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Gallus gallus)
REACT:R-RNO-912757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S585-IL3RB binds 14-3-3 proteins (Rattus norvegicus)
RHEA:44168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+)
EC:1.1.1.119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose 1-dehydrogenase (NADP(+))"
EC:1.1.1.119	skos:prefLabel	"glucose 1-dehydrogenase (NADP(+))"
REACT:R-DRE-1678716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(1) (Danio rerio)
REACT:R-GGA-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Gallus gallus)
GO:1905201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin transmembrane transporter activity
REACT:R-HSA-5635839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3:SUFU dissociates (Homo sapiens)
GO:0018511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity
GO:0018511	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity
RHEA:17598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + 2 Fe(III)-[cytochrome c] => D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)
RHEA:13146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate => alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine
REACT:R-CEL-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Caenorhabditis elegans)
REACT:R-SSC-5687484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Sus scrofa)
RHEA:58386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + octanal => NADP(+) + octan-1-ol
REACT:R-DME-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Drosophila melanogaster)
REACT:R-DDI-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Dictyostelium discoideum)
RHEA:17683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-3-oxopropanoate + H(+) + NADH => 3-hydroxy-2-methylpropanoate + NAD(+)
RHEA:67309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one
EC:5.6.2.1	skos:altLabel	"type I DNA topoisomerase"
EC:5.6.2.1	skos:altLabel	"omega-protein"
EC:5.6.2.1	skos:altLabel	"untwisting enzyme"
EC:5.6.2.1	skos:prefLabel	"DNA topoisomerase"
EC:5.6.2.1	skos:altLabel	"swivelase"
EC:5.6.2.1	skos:altLabel	"DNA topoisomerase I"
EC:5.6.2.1	skos:altLabel	"nicking-closing enzyme"
EC:5.6.2.1	skos:altLabel	"relaxing enzyme"
EC:5.6.2.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA topoisomerase"
REACT:R-CEL-8933328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYPLA2 hydrolyses PALM-C3,4-GAP43 (Caenorhabditis elegans)
REACT:R-HSA-4093336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
RHEA:68819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> (E)-alpha-bisabolene + diphosphate
RHEA:43116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine
RHEA:50137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (9Z)-octadecenoate + H2O => (9Z)-octadecenoate + ethanol + H(+)
RHEA:12955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein] => ATP + L-seryl-[Goodpasture antigen-binding protein]
REACT:R-SCE-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Saccharomyces cerevisiae)
REACT:R-MMU-5684006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translocates NBN to the nucleus (Mus musculus)
RHEA:53924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine
RHEA:26344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-selenocysteine + S-methyl-L-methionine <=> H(+) + L-methionine + Se-methyl-L-selenocysteine
RHEA:16939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-sn-glycerol + ATP
REACT:R-RNO-2328037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds integrins (Rattus norvegicus)
REACT:R-RNO-174445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap on the C-strand (Rattus norvegicus)
RHEA:57264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP = GDP + glycolate + H(+)
RHEA:23933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-glucosamine 6-phosphate => an N-acyl-D-mannosamine 6-phosphate
GO:0050519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citrate lyase holo-[acyl-carrier protein] synthase"
GO:0050519	skos:altLabel	"holo-ACP synthase"
GO:0050519	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity
GO:0050519	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	holo-ACP synthase activity
GO:0050519	skos:prefLabel	"citrate lyase holo-[acyl-carrier protein] synthase"
GO:0050519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] = diphosphate + holo-[citrate lyase ACP]
GO:0050519	skos:altLabel	"holo-citrate lyase synthase"
GO:0050519	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity
GO:0050519	skos:altLabel	"2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase"
GO:0050519	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CitX
GO:0050519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-citrate lyase synthase activity
GO:0050519	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity
RHEA:43068	skos:altLabel	"CYP16A75"
RHEA:43068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-amyrin 28-monooxygenase"
RHEA:43068	skos:altLabel	"CYP716A12"
RHEA:43068	skos:altLabel	"CYP716A52v2"
RHEA:43068	skos:prefLabel	"beta-amyrin 28-monooxygenase"
RHEA:43068	skos:altLabel	"beta-amyrin 28-oxidase"
RHEA:43068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:39179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-eicosenoyl-CoA + H(+) + NADPH = eicosanoyl-CoA + NADP(+)
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MraY transferase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoacetylmuramoylpentapeptide translocase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-MurNAc-pentapeptide transferase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoacetylmuramoylpentapeptidetransferase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-N-acetylmuramoyl pentapeptide translocase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-MurNAc-pentapeptide phosphotransferase activity
GO:0008963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospho-N-acetylmuramoyl-pentapeptide-transferase activity
RHEA:17175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + spermidine => glutathionylspermidine + H2O
RHEA:42802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diaponeurosporene + 3 FADH2 => 15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+)
REACT:R-CFA-8869633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NR to yield NMN (Canis familiaris)
REACT:R-RNO-8932633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Rattus norvegicus)
REACT:R-RNO-6783681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIF binds LIFR (Rattus norvegicus)
RHEA:30268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 monodehydro-L-ascorbate radical => L-ascorbate + L-dehydroascorbate
REACT:R-HSA-5610746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI3 (Homo sapiens)
REACT:R-GGA-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Gallus gallus)
REACT:R-GGA-1112708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-Y759-IL6ST (Gallus gallus)
REACT:R-CFA-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-SSC-196372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Sus scrofa)
RHEA:18569	skos:prefLabel	"aryl-aldehyde oxidase"
RHEA:18569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aryl-aldehyde oxidase"
RHEA:18569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + H2O + O2 = an aromatic carboxylate + H(+) + H2O2
REACT:R-HSA-2022411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
REACT:R-CFA-8940561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP7 cleaves OPTC (Canis familiaris)
GO:0038054	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	estrogen receptor activity
GO:0038054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled estrogen receptor activity
GO:0038054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled estrogen receptor activity
REACT:R-DRE-4084912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arresten binds integrin alpha1beta1 (Danio rerio)
RHEA:10032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidyl-glutaminase"
RHEA:10032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal-L-glutamine + H2O = [protein]-C-terminal-L-glutamate + NH4(+)
RHEA:10032	skos:prefLabel	"peptidyl-glutaminase"
RHEA:10032	skos:altLabel	"peptidoglutaminase I"
GO:0045125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bioactive lipid receptor activity
RHEA:30184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH
REACT:R-SSC-2404131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Sus scrofa)
RHEA:70417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dihydroxyphenyl)acetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + H2O
REACT:R-XTR-5696358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREM,CD300 binds lipids (Xenopus tropicalis)
RHEA:28878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-tyrosine(in) <=> H(+)(out) + L-tyrosine(out)
REACT:R-BTA-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Bos taurus)
RHEA:33126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate <=> (R)-tetraprenyl-beta-curcumene + diphosphate
RHEA:57931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate
RHEA:69907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + uridine(out) = 2 Na(+)(in) + uridine(in)
RHEA:20407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,6S)-2,6-diaminoheptanedioate + acetate => H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate
RHEA:56450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-GGA-1592371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP3 (Gallus gallus)
GO:0050333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine triphosphatase activity
GO:0050333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine-triphosphate phosphohydrolase activity
GO:0050333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine triphosphate phosphatase activity
GO:0050333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ThTPase activity
GO:0050333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin-triphosphatase activity
GO:0050333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine-triphosphatase activity
RHEA:64976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTP + 2 H2O = 8-oxo-dGMP + 2 H(+) + 2 phosphate
REACT:R-MMU-2161950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Mus musculus)
RHEA:55828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Mus musculus)
REACT:R-SCE-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Saccharomyces cerevisiae)
REACT:R-HSA-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
REACT:R-XTR-5661290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Xenopus tropicalis)
GO:0050083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malyl-coenzyme A lyase activity
GO:0050083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity
GO:0050083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)
GO:0050083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malyl-CoA lyase activity
REACT:R-DME-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Drosophila melanogaster)
REACT:R-RNO-3928601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 and PIP2 bind WASL, activating it (Rattus norvegicus)
REACT:R-XTR-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)
REACT:R-HSA-9006332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 transphosphorylates and is activated in response to Erythropoietin (Homo sapiens)
REACT:R-CEL-8952625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Caenorhabditis elegans)
REACT:R-HSA-182988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty lures CBL away from EGFR (Homo sapiens)
REACT:R-HSA-9672178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to PDGFRA extracellular domain dimers (Homo sapiens)
RHEA:26312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> 1,4-dihydroxy-2-naphthoate + CoA + H(+)
GO:0016874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	synthetase activity
GO:0016874	skos:prefLabel	"Ligases"
GO:0016874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase activity
GO:0016874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Ligases"
RHEA:51486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-4084912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arresten binds integrin alpha1beta1 (Gallus gallus)
REACT:R-SSC-5617143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)
REACT:R-BTA-77309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Bos taurus)
REACT:R-CFA-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Canis familiaris)
REACT:R-DME-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)
RHEA:50499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]
REACT:R-RNO-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Rattus norvegicus)
RHEA:67108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine
REACT:R-SPO-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)
REACT:R-BTA-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Bos taurus)
REACT:R-MMU-76466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4A11 12-hydroxylates DDCX (Mus musculus)
REACT:R-RNO-420739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPRC6A can bind L-alpha amino acids and calcium (Rattus norvegicus)
RHEA:68570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-1,2-diazinane-3-carboxylate + H(+) + H2O => N(5)-hydroxy-L-ornithine
RHEA:62443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl methyl ester](n) <=> 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)
REACT:R-XTR-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Xenopus tropicalis)
REACT:R-XTR-5653936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Ragulator complex (Xenopus tropicalis)
RHEA:31766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid
REACT:R-CFA-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Canis familiaris)
RHEA:37487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-SSC-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Sus scrofa)
REACT:R-XTR-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Xenopus tropicalis)
REACT:R-HSA-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)
GO:0047955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol dehydrogenase (acceptor) activity
GO:0047955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol:(acceptor) 1-oxidoreductase activity
GO:0047955	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol:acceptor 1-oxidoreductase activity
RHEA:45995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O
REACT:R-HSA-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Homo sapiens)
GO:0008658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	penicillin binding
REACT:R-HSA-5651792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 and POLB dissociate from repaired dsDNA (Homo sapiens)
RHEA:32556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => (R)-alpha-terpineol + diphosphate
REACT:R-XTR-8870489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA4,(5,6) bind PI3P (Xenopus tropicalis)
REACT:R-GGA-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Gallus gallus)
REACT:R-XTR-183072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR non-clathrin mediated endocytosis (Xenopus tropicalis)
RHEA:62138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGDP + GDP => dGMP + GTP
RHEA:13464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 <=> 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)
GO:0018446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pinocarveol dehydrogenase activity
RHEA:10441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone + H2O => D-gluconate + H(+)
REACT:R-DME-445069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-EGFR trans-heterodimerization (Drosophila melanogaster)
GO:0043428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
GO:0043428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO:0043428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity
REACT:R-XTR-3785684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by CTSG (Xenopus tropicalis)
REACT:R-BTA-202437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 (Bos taurus)
RHEA:27411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a menaquinol + protoporphyrin IX => 3 a menaquinone + protoporphyrinogen IX
REACT:R-XTR-1963589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Xenopus tropicalis)
RHEA:27759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)
RHEA:56326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein] => (2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein]
REACT:R-SSC-8852298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Sus scrofa)
REACT:R-MMU-8948775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKRN1 polyubiquitinates PTEN (Mus musculus)
RHEA:59929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythritol + NADP(+) => D-erythrose + H(+) + NADPH
RHEA:51703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthogalenol <=> 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine
RHEA:71150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhispidin + O2 <=> 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one
RHEA:71907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide
REACT:R-DRE-211983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2J2 oxidises ARA (Danio rerio)
RHEA:51460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-glutamate = (9Z)-octadecenoate + L-glutamate
REACT:R-XTR-1433418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Xenopus tropicalis)
REACT:R-DME-6810474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Drosophila melanogaster)
REACT:R-SPO-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Schizosaccharomyces pombe)
REACT:R-HSA-9749197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 binds to H4K20me2 (Homo sapiens)
REACT:R-DDI-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Dictyostelium discoideum)
REACT:R-MMU-6786245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNS1 transforms ATP, L-His, b-Ala to CARN (Mus musculus)
REACT:R-PFA-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Plasmodium falciparum)
REACT:R-DRE-9664881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Danio rerio)
REACT:R-HSA-1248677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody (Homo sapiens)
RHEA:41029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA
REACT:R-SSC-5654596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)
RHEA:12434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine => L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
REACT:R-CEL-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Caenorhabditis elegans)
RHEA:19525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (1S,8aR)-delta-cadinene + diphosphate
RHEA:19525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-delta-cadinene synthase"
RHEA:19525	skos:altLabel	"D-cadinene synthase"
RHEA:19525	skos:prefLabel	"(+)-delta-cadinene synthase"
RHEA:10408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA
RHEA:52772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate
RHEA:52772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroneopterin triphosphate aldolase"
RHEA:52772	skos:prefLabel	"dihydroneopterin triphosphate aldolase"
REACT:R-SPO-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Schizosaccharomyces pombe)
REACT:R-DME-5654730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Drosophila melanogaster)
REACT:R-DDI-8940388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPLD1 hydrolyses GPI-anchors from proteins (Dictyostelium discoideum)
RHEA:67592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)
RHEA:14688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a primary alcohol <=> AH2 + an aldehyde
RHEA:41180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)
REACT:R-DRE-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Danio rerio)
RHEA:70056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cremeomycin => 2-hydroxy-4-methoxybenzoate + A + N2
GO:0015182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine transmembrane transporter activity
GO:0015182	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-asparagine transporter activity
GO:0015182	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	asparagine/glutamine permease activity
RHEA:64741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate
REACT:R-SSC-8955844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBKS phosphorylates ribose to R5P (Sus scrofa)
REACT:R-SSC-111804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)
REACT:R-BTA-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Bos taurus)
RHEA:20524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate + NAD(+) <=> acetoacetate + H(+) + NADH
REACT:R-XTR-3132737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate ETS1 and ETS2 (Xenopus tropicalis)
REACT:R-HSA-9625378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STK11 gene transcription is stimulated by FOXO3,FOXO4 (Homo sapiens)
REACT:R-CFA-5626549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind CALM1 (Canis familiaris)
REACT:R-GGA-975902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)
RHEA:10936	skos:altLabel	"thiosulfate:quinone oxidoreductase"
RHEA:10936	skos:prefLabel	"thiosulfate dehydrogenase (quinone)"
RHEA:10936	skos:altLabel	"TQO"
RHEA:10936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate
RHEA:10936	skos:altLabel	"thiosulfate oxidoreductase, tetrathionate-forming"
RHEA:10936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiosulfate dehydrogenase (quinone)"
REACT:R-SSC-6810472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT13 hydrolyses AP6A to AP4 and ADP (Sus scrofa)
REACT:R-HSA-6805785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates PHF20 (Homo sapiens)
REACT:R-HSA-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)
RHEA:41176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) => methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine
RHEA:41203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:29861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-ribose + adenine => 5'-deoxyadenosine + H2O
REACT:R-RNO-2064421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds ZO-2 (TJP2) (Rattus norvegicus)
RHEA:49847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid + a quinone <=> (-)-dehydrodiconiferyl acid ketone + a quinol
RHEA:30594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + tyramine <=> (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)
REACT:R-RNO-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Rattus norvegicus)
REACT:R-HSA-109539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Homo sapiens)
REACT:R-CFA-195418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-2 associates with VEGFR1 forming complexes on  cell surface (Canis familiaris)
REACT:R-DRE-4093327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHA binds TIAM1 (Danio rerio)
RHEA:22996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-ascorbate peroxidase"
RHEA:22996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + L-ascorbate = 2 H2O + L-dehydroascorbate
RHEA:22996	skos:altLabel	"ascorbic acid peroxidase"
RHEA:22996	skos:prefLabel	"L-ascorbate peroxidase"
GO:0008855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exodeoxyribonuclease VII activity
GO:0008855	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	E. coli exonuclease VII activity
GO:0008855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E. coli exonuclease VII
GO:0008855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Escherichia coli exonuclease VII
GO:0008855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endodeoxyribonuclease VII
GO:0008855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exonuclease VII activity
REACT:R-CFA-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Canis familiaris)
REACT:R-CEL-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Caenorhabditis elegans)
RHEA:24262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopent-4-enoate + CO2 => (3E)-2-oxohex-3-enedioate + H(+)
RHEA:32193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Danio rerio)
REACT:R-BTA-3322019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-b (Bos taurus)
REACT:R-MMU-4224014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by ADAM10, ADAM15 (Mus musculus)
REACT:R-CEL-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Caenorhabditis elegans)
RHEA:21063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dichloroaniline + malonyl-CoA <=> CoA + N-(3,4-dichlorophenyl)malonamate
GO:0018751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dichlorophenylcarboximide hydrolase activity
REACT:R-CFA-5686578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates ABL1 (Canis familiaris)
RHEA:43477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoate + O2 => 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate
REACT:R-SSC-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Sus scrofa)
REACT:R-RNO-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Rattus norvegicus)
RHEA:72009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate(out) + urate(in) => succinate(in) + urate(out)
GO:0030058	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	primary-amine:acceptor oxidoreductase (deaminating)
GO:0030058	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	primary-amine dehydrogenase activity
GO:0030058	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amine: (acceptor) oxidoreductase (deaminating)
GO:0030058	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MADH activity
GO:0030058	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylamine dehydrogenase activity
GO:0030058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amine dehydrogenase activity
RHEA:70858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + L-serine(in) + Na(+)(out) <=> L-glutamine(in) + L-serine(out) + Na(+)(in)
GO:0033940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feraxan endoxylanase activity
GO:0033940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronoxylan xylanohydrolase activity
GO:0033940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronoxylanase activity
GO:0033940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronoarabinoxylan endo-1,4-beta-xylanase activity
GO:0033940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity
GO:0033940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoarabinoxylanase activity
GO:0033940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronoxylan xylohydrolase activity
GO:0033940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feraxanase activity
RHEA:53495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) <=> 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)
REACT:R-GGA-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Gallus gallus)
REACT:R-MMU-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Mus musculus)
REACT:R-GGA-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Gallus gallus)
RHEA:47552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate + H2O = deoxycholate + glycine
REACT:R-DME-937044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 (Drosophila melanogaster)
RHEA:51496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)
REACT:R-SSC-5689649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 (Sus scrofa)
RHEA:71277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + taurolithocholate 3-sulfate(in) => 2 Na(+)(out) + taurolithocholate 3-sulfate(out)
RHEA:63945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + sphinga-4E,14Z-dienine => an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)
RHEA:34296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP
REACT:R-DRE-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Danio rerio)
RHEA:10494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + phosphate => H2O + phosphocholine
REACT:R-SSC-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Sus scrofa)
REACT:R-MMU-5694563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD10 hydrolyses MPAG (Mus musculus)
RHEA:25838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-glucuronate + H(+) => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O
REACT:R-MMU-5229132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 binds APP (Mus musculus)
RHEA:32157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine => 7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine
RHEA:20568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> (1S,2S,4R)-endo-fenchol + diphosphate
REACT:R-DRE-400204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds RXRA (Danio rerio)
REACT:R-SSC-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)
RHEA:33633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + octanoyl-CoA => ATP + CoA + octanoate
REACT:R-RNO-8877620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE2 cleaves EDN1(53-90) (Rattus norvegicus)
REACT:R-HSA-8871266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD3 (Homo sapiens)
GO:0034235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI anchor binding
GO:0034235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosylphosphatidylinositol binding
REACT:R-XTR-8987223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10RB binds TYK2 (Xenopus tropicalis)
GO:0004053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine amidinase activity
GO:0004053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginase activity
GO:0004053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	canavanase activity
GO:0004053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine amidinohydrolase activity
GO:0004053	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine transamidinase activity
GO:0004053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginase activity
REACT:R-BTA-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)
REACT:R-HSA-373705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of DCC (Homo sapiens)
REACT:R-CFA-5693108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Canis familiaris)
REACT:R-MMU-8949661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Mus musculus)
REACT:R-BTA-173725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C9 binds C5b:C6:C7:C8 (Bos taurus)
REACT:R-SSC-180047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates DARPP-32 on Thr75 (Sus scrofa)
REACT:R-BTA-2328033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds latent TGF-beta (Bos taurus)
REACT:R-MMU-5661121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Mus musculus)
REACT:R-XTR-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)
RHEA:39027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP
EC:1.1.2.7	skos:altLabel	"MDH"
EC:1.1.2.7	skos:prefLabel	"methanol dehydrogenase (cytochrome c)"
EC:1.1.2.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methanol dehydrogenase (cytochrome c)"
EC:1.1.2.7	skos:altLabel	"methanol dehydrogenase"
GO:0044875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-glutamyl hercynylcysteine S-oxide synthase
GO:0044875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-glutamyl hercynylcysteine sulfoxide synthase
GO:0044875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-glutamyl hercynylcysteine sulfoxide synthase activity
REACT:R-HSA-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Homo sapiens)
REACT:R-BTA-5654224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds PLCG1 (Bos taurus)
REACT:R-SSC-5661240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCXR tetramer reduces L-xylulose to xylitol (Sus scrofa)
RHEA:39345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA
RHEA:46760	skos:prefLabel	"2,4-dinitrotoluene dioxygenase"
RHEA:46760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-dinitrotoluene dioxygenase"
RHEA:46760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitrotoluene + NADH + O2 = 4-methyl-5-nitrocatechol + NAD(+) + nitrite
EC:3.4.21.59	skos:altLabel	"pituitary tryptase"
EC:3.4.21.59	skos:prefLabel	"tryptase"
EC:3.4.21.59	skos:altLabel	"mast cell tryptase"
EC:3.4.21.59	skos:altLabel	"mast cell protease II"
EC:3.4.21.59	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptase"
EC:3.4.21.59	skos:altLabel	"skin tryptase"
EC:3.4.21.59	skos:altLabel	"lung tryptase"
GO:0043021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNP binding
GO:0043021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleoprotein complex binding
GO:0043021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-RNA complex binding
GO:0043021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleoprotein binding
REACT:R-SSC-8853745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA3 (Sus scrofa)
REACT:R-DRE-163120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Telomerase RNP and the Chromosome End (Danio rerio)
GO:1990458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipooligosaccharide binding
GO:1990458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endotoxin binding
GO:1990458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LOS binding
RHEA:39122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2
RHEA:18591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate => [glutamine synthetase]-L-tyrosine + ATP
REACT:R-BTA-375330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 45/Connexin 36 mediated neuronal gap junction communication (Bos taurus)
EC:1.3.1.104	skos:altLabel	"acyl-ACP dehydrogenase"
EC:1.3.1.104	skos:prefLabel	"enoyl-[acyl-carrier-protein] reductase"
EC:1.3.1.104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enoyl-[acyl-carrier-protein] reductase"
EC:1.3.1.104	skos:altLabel	"enoyl-ACP reductase"
RHEA:60383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dehydroascorbate(out) <=> L-dehydroascorbate(in)
REACT:R-PFA-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Plasmodium falciparum)
REACT:R-DRE-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Danio rerio)
REACT:R-SSC-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Sus scrofa)
REACT:R-SSC-2197697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Sus scrofa)
REACT:R-BTA-2046097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)
REACT:R-CFA-198983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NKG2D homodimer interacting with ligands (Canis familiaris)
RHEA:63852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 = (2R)-2-hydroperoxydodecanoate
RHEA:42979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan <=> 2-aminoprop-2-enoate + indole
RHEA:70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O <=> beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose
REACT:R-HSA-9622630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO3,FOXO4,(FOXO1) bind BCL6 gene promoter (Homo sapiens)
RHEA:51553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + NADP(+) => H(+) + L-xylo-3-hexulose + NADPH
REACT:R-HSA-8851044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN1A1 binds xanthine oxidoreductase (XDH) (Homo sapiens)
GO:0140082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-ubiquitin ligase activity
REACT:R-DDI-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Dictyostelium discoideum)
RHEA:43693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]
RHEA:64002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoyl-CoA
REACT:R-DRE-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Danio rerio)
REACT:R-GGA-6813626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEAP2 binds bacteria (Gallus gallus)
REACT:R-BTA-399936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of integrin activation by sequestering PIP5KIgamma (Bos taurus)
RHEA:56324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase"
RHEA:56324	skos:prefLabel	"methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase"
RHEA:56324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] = 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]
GO:0005163	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin
GO:0005163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nerve growth factor receptor binding
GO:0005163	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nerve growth factor receptor ligand
GO:0005163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF receptor binding
RHEA:42773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:62588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) = 4-hydroxybenzyl alcohol + CO2
RHEA:50045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H2O => adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)
REACT:R-GGA-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Gallus gallus)
REACT:R-SSC-8944225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVII (Sus scrofa)
REACT:R-HSA-2972960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter (Homo sapiens)
RHEA:16347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,7E)-dolabella-3,7-dien-18-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O
GO:0031735	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR10 chemokine receptor ligand
GO:0031735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR10 chemokine receptor binding
RHEA:50145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (9Z)-hexadecenoate + H2O => (9Z)-hexadecenoate + ethanol + H(+)
REACT:R-DRE-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Danio rerio)
RHEA:20289	skos:altLabel	"acetyl-CoA deacylase"
RHEA:20289	skos:prefLabel	"acetyl-CoA hydrolase"
RHEA:20289	skos:altLabel	"acetyl-CoA acylase"
RHEA:20289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O = acetate + CoA + H(+)
RHEA:20289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetyl-CoA hydrolase"
REACT:R-HSA-3857348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CEBPB stimulates transcription of CDKN2B (Homo sapiens)
REACT:R-RNO-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
REACT:R-SSC-71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Sus scrofa)
REACT:R-DRE-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Danio rerio)
RHEA:42433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-cis,cis-muconate => maleylacetate
RHEA:47334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:69335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:54250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine
REACT:R-DME-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Drosophila melanogaster)
REACT:R-CFA-3371518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 binds to HSF1 (Canis familiaris)
REACT:R-SSC-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Sus scrofa)
REACT:R-DME-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Drosophila melanogaster)
REACT:R-CEL-451311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)
REACT:R-GGA-3965447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein subunits dissociate from WNT:FZD complex (Gallus gallus)
REACT:R-RNO-5607722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK phosphorylates IKKA dimer (Rattus norvegicus)
RHEA:10230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate + H2O => citrate
REACT:R-CFA-9624778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD 12mer translocates from ER membrane to extracellular region (Canis familiaris)
REACT:R-RNO-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Rattus norvegicus)
REACT:R-PFA-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Plasmodium falciparum)
RHEA:53200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-9699579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of FLT3  (Danio rerio)
RHEA:36122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A9 + S-adenosyl-L-methionine <=> O-methyl gibberellin A9 + S-adenosyl-L-homocysteine
RHEA:16118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + ATP + CoA => acetoacetyl-CoA + AMP + diphosphate
GO:0004996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyrotropin receptor
GO:0004996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSH receptor activity
GO:0004996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyroid stimulating hormone receptor activity
GO:0004996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyroid-stimulating hormone receptor activity
RHEA:59612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-L-ornithine + H2O = beta-alanine + L-ornithine
REACT:R-CEL-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)
REACT:R-HSA-5666129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
REACT:R-BTA-1475422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)
REACT:R-SCE-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Saccharomyces cerevisiae)
GO:0008316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of vitelline membrane
REACT:R-CFA-8986985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Canis familiaris)
RHEA:34434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-secoisolariciresinol + NADP(+) <=> (-)-lariciresinol + H(+) + NADPH
REACT:R-RNO-5654734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Rattus norvegicus)
REACT:R-HSA-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
REACT:R-BTA-1602398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Bos taurus)
REACT:R-BTA-6803892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds BAX (Bos taurus)
REACT:R-HSA-936380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PIN1 with p-IRF3 (Homo sapiens)
RHEA:24921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobut-2-enoate + H2O => L-homoserine
REACT:R-MMU-5654633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS bind to PPTN11 (Mus musculus)
REACT:R-GGA-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Gallus gallus)
RHEA:39405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH
RHEA:42556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA
RHEA:42556	skos:prefLabel	"21S rRNA pseudouridine(2819) synthase"
RHEA:42556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"21S rRNA pseudouridine(2819) synthase"
RHEA:34802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-didehydroadipoyl-CoA + acetyl-CoA <=> 3-oxo-5,6-didehydrosuberyl-CoA + CoA
RHEA:59090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => D-histidine + S-adenosyl-L-methionine
REACT:R-XTR-159050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Xenopus tropicalis)
RHEA:46843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:11389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11beta-hydroxysteroid + NADP(+) => an 11-oxosteroid + H(+) + NADPH
REACT:R-MMU-200421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of cytosolic AMPK by phosphorylation (Mus musculus)
REACT:R-RNO-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Rattus norvegicus)
GO:0047554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-pyrone-4,6-dicarboxylate lactonase activity
GO:0047554	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-pyrone-4,6-dicarboxylate lactonohydrolase activity
REACT:R-SSC-8854182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D17 binds OPTN:RAB8A (Sus scrofa)
REACT:R-RNO-975040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAB-ZNF / KAP Interaction (Rattus norvegicus)
REACT:R-HSA-6803527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)
RHEA:59366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+) => 1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O
REACT:R-HSA-163625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon binds to Glucagon receptor (Homo sapiens)
RHEA:52821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + succinyl-CoA => CoA + O-succinyl-L-serine
RHEA:45260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracosanoate(out) = tetracosanoate(in)
RHEA:20242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate + S-adenosyl-L-methionine => N-methylnicotinate + S-adenosyl-L-homocysteine
REACT:R-CEL-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Caenorhabditis elegans)
REACT:R-DME-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)
REACT:R-XTR-4641236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates FZD to potentiate WNT signaling (Xenopus tropicalis)
RHEA:71317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-serine(in) + 2 Na(+)(in) => chloride(out) + L-serine(out) + 2 Na(+)(out)
RHEA:32145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) => L-arginine(in)
REACT:R-SSC-4641249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Sus scrofa)
RHEA:31644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycinamicin VI + S-adenosyl-L-methionine => H(+) + mycinamicin III + S-adenosyl-L-homocysteine
RHEA:36710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-ureido-L-serine <=> O-ureido-D-serine
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxosteroid:(acceptor) delta1-oxidoreductase activity
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketosteroid-1-en-dehydrogenase activity
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta1-dehydrogenase activity
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxosteroid:acceptor delta1-oxidoreductase activity
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta1-steroid reductase activity
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketosteroid-delta1-dehydrogenase activity
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-ene-dehydrogenase activity
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosteroid 1-dehydrogenase activity
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity
GO:0047571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxosteroid delta1-dehydrogenase activity
RHEA:18815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5R)-5-carboxy-2-oxohept-3-enedioate => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate
REACT:R-CFA-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Canis familiaris)
REACT:R-HSA-2559414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
GO:0047854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diguanidinobutanase activity
GO:0047854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-diguanidinobutane amidinohydrolase activity
REACT:R-CFA-5654631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PPTN11 (Canis familiaris)
RHEA:52947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + UDP-alpha-D-glucuronate <=> choloyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-CEL-399936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of integrin activation by sequestering PIP5KIgamma (Caenorhabditis elegans)
REACT:R-RNO-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Rattus norvegicus)
RHEA:68891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxybenzoate + ATP + H(+) + NADPH <=> 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)
REACT:R-MMU-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Mus musculus)
RHEA:55115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)
REACT:R-SPO-8932276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Schizosaccharomyces pombe)
REACT:R-SCE-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Saccharomyces cerevisiae)
RHEA:21676	skos:prefLabel	"lavandulyl diphosphate synthase"
RHEA:21676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lavandulyl diphosphate synthase"
RHEA:21676	skos:altLabel	"FDS-5"
RHEA:21676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dimethylallyl diphosphate = (R)-lavandulyl diphosphate + diphosphate
REACT:R-CEL-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Caenorhabditis elegans)
REACT:R-HSA-6786854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript (Homo sapiens)
GO:0047155	skos:prefLabel	"3-hydroxymethylcephem carbamoyltransferase"
GO:0047155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxymethylcephem carbamoyltransferase"
GO:0047155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxymethylcephem carbamoyltransferase activity
GO:0047155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-hydroxymethylcephem-O-carbamoyltransferase activity
GO:0047155	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity
REACT:R-BTA-1112604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STATs are released (Bos taurus)
REACT:R-DRE-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Danio rerio)
REACT:R-MMU-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Mus musculus)
REACT:R-XTR-934604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SPRY2 is ubiquitinated by CBL (Xenopus tropicalis)
REACT:R-HSA-8944104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
REACT:R-XTR-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)
RHEA:33912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-alkylglycine + H2O + O2 => an alkylamine + glyoxylate + H2O2
RHEA:71970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) <=> (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)
REACT:R-RNO-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Rattus norvegicus)
RHEA:31129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol => 3-O-methylgallate + O2
RHEA:63065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + tetraacetate lactone
RHEA:45044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 = 2 Fe(III)-[cytochrome c] + H2O + nitrite
RHEA:63060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylorsellinate + ATP + H(+) + NADPH = 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)
RHEA:10343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-vetispiradiene + diphosphate
REACT:R-SSC-6786072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3,p-Y641-STAT6 dissociate (Sus scrofa)
RHEA:31681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + prosolanapyrone III => O2 + prosolanapyrone II
REACT:R-MMU-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Mus musculus)
RHEA:40729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid
RHEA:22379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(38/39/40) in tRNA <=> pseudouridine(38/39/40) in tRNA
REACT:R-MMU-6788867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3K phosphorylates ketosamines (Mus musculus)
REACT:R-HSA-2161899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)
REACT:R-RNO-8853792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET tyrosine phosphorylation (Rattus norvegicus)
RHEA:24223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:29342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + 2 H(+)(in) <=> (S)-malate(out) + 2 H(+)(out)
REACT:R-CFA-6801666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates CENPJ (Canis familiaris)
REACT:R-HSA-8956025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Homo sapiens)
REACT:R-CFA-113402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:early elongation complex (Canis familiaris)
RHEA:42423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysine + O2 <=> (4R)-4-hydroxy-L-lysine + CO2 + succinate
REACT:R-BTA-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Bos taurus)
REACT:R-XTR-8870352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-HSA-432237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Homo sapiens)
REACT:R-CFA-3240295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Canis familiaris)
RHEA:33437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	episterol => fecosterol
REACT:R-DRE-9018859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Danio rerio)
REACT:R-MMU-83677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4 deamination of cytidine (Mus musculus)
RHEA:13808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-5alpha-steroid <=> a 3-oxo-Delta(4)-steroid + AH2
REACT:R-RNO-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Rattus norvegicus)
REACT:R-XTR-216727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Xenopus tropicalis)
RHEA:25283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + squalene => (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-166817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by C3 convertases (Xenopus tropicalis)
GO:0042131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin phosphate phosphatase activity
GO:0042131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ThMPase
GO:0042131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin monophosphate phosphatase
GO:0042131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine phosphate phosphatase activity
RHEA:69617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-SSC-8855617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Sus scrofa)
REACT:R-XTR-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)
REACT:R-CFA-1855179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Canis familiaris)
RHEA:44293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
RHEA:67384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-2730851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
REACT:R-RNO-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)
REACT:R-CFA-175983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfer CH3 from AdoMet to 3,4DHBNZ (Canis familiaris)
REACT:R-DRE-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Danio rerio)
RHEA:29876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-L-serine => H(+) + L-serine + sn-glycerol 3-phosphate
RHEA:64414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) => H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)
RHEA:39037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-oxo fatty acid + H(+) + NADH => an omega-hydroxy fatty acid + NAD(+)
REACT:R-DRE-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Danio rerio)
RHEA:40379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
RHEA:36598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + NADP(+) <=> NADPH + sulfur
REACT:R-HSA-8875071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSS3 ligates CoA to CH3COO- (Homo sapiens)
GO:0018528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iminodiacetate dehydrogenase activity
RHEA:41358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH => bacteriochlorophyll a + 3 NADP(+)
GO:0004028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloroallyl aldehyde dehydrogenase activity
GO:0004028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Homo sapiens)
REACT:R-CEL-428888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ROBO1 by ABL kinase (Caenorhabditis elegans)
REACT:R-SCE-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)
REACT:R-RNO-8865265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds MYC and KDM5B (Rattus norvegicus)
REACT:R-DRE-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Danio rerio)
RHEA:49565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate => 2-epi-valiolone + phosphate
REACT:R-GGA-9690439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds LTC4,LTD4,LTE4 (Gallus gallus)
REACT:R-MMU-194689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Mus musculus)
RHEA:52794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg(2+) + pheophorbide a => chlorophyllide a + 2 H(+)
RHEA:28270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + spermidine = CoA + H(+) + N(8)-acetylspermidine
REACT:R-RNO-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Rattus norvegicus)
REACT:R-XTR-977605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H displaces Bb (Xenopus tropicalis)
REACT:R-CFA-9708536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 translocates from the cytosol to the nucleoplasm (Canis familiaris)
REACT:R-SSC-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Sus scrofa)
RHEA:15665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucose + L-lysyl-[protein] = H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]
REACT:R-MMU-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Mus musculus)
RHEA:29754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(in) <=> acetoacetate(out)
REACT:R-SSC-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Sus scrofa)
REACT:R-DRE-382054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binds to extracellular matrix proteins (Danio rerio)
REACT:R-CFA-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Canis familiaris)
RHEA:41368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:59853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)
REACT:R-DRE-77309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Danio rerio)
RHEA:25845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5R)-carveol + NAD(+) => (R)-carvone + H(+) + NADH
RHEA:53533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O
RHEA:49655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protoviolaceinate <=> H2O + NAD(+) + violaceinate
RHEA:57157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[protein] + O2 => 4-hydroxy-L-lysyl-[protein] + CO2 + succinate
RHEA:56727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-beta-carotene + O2 <=> 4-hydroxy-all-trans-beta-carotene + A + H2O
REACT:R-DRE-193385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of choloyl-CoA to cholate and CoASH (Danio rerio)
REACT:R-HSA-9619376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK1 binds calmodulin (Homo sapiens)
REACT:R-DRE-3222116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L3MBTL1 binds TP53 monomethylated on K382 (Danio rerio)
REACT:R-BTA-73815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
RHEA:46271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:48157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GQ1b (d18:1(4E)) + H2O => ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate
RHEA:30665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hapalindole H => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole
GO:0008267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly-glutamine tract binding
REACT:R-DME-2424485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-PLCG1 (Drosophila melanogaster)
RHEA:53966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP] => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin
RHEA:12039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(imidazol-5-yl)lactate + NAD(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADH
REACT:R-MMU-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Mus musculus)
RHEA:31835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose
RHEA:31835	skos:prefLabel	"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)"
RHEA:31835	skos:altLabel	"TDP-6-deoxy-hex-4-ulose isomerase"
RHEA:31835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)"
RHEA:31835	skos:altLabel	"dTDP-6-deoxy-hex-4-ulose isomerase"
RHEA:53601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
REACT:R-RNO-450827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Rattus norvegicus)
RHEA:56044	skos:prefLabel	"endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase"
RHEA:56044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase"
RHEA:56044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)
REACT:R-RNO-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Rattus norvegicus)
REACT:R-HSA-9749977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A6 glucuronates ST (Homo sapiens)
RHEA:64947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + 2 H2O <=> dCMP + 2 H(+) + 2 phosphate
RHEA:29012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + H(+)(in) => 2-oxoglutarate(out) + H(+)(out)
GO:0033441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine tRNA
GO:0033441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAU codon-amino acid adaptor activity
GO:0033441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAT codon-amino acid adaptor activity
REACT:R-CFA-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)
REACT:R-GGA-6814187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVL:PPL heterodimer binds the inner surface of the plasma membrane (Gallus gallus)
RHEA:38106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate + H2O
REACT:R-MMU-8984014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Mus musculus)
REACT:R-HSA-2426146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds the FDFT1 promoter (Homo sapiens)
REACT:R-CFA-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
RHEA:44414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + ubiquinol-10 => 3-demethylubiquinol-10 + S-adenosyl-L-methionine
RHEA:31379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyrrole-2-carboxylate = 1H-pyrrole + hydrogencarbonate
REACT:R-DRE-6782820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates SUDS3 (Danio rerio)
GO:0045174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHA reductase activity
GO:0045174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:dehydroascorbic acid oxidoreductase activity
GO:0045174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:dehydroascorbate oxidoreductase activity
GO:0045174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroascorbate reductase activity
GO:0045174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione dehydroascorbate reductase activity
GO:0045174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDOR
GO:0045174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydroascorbic acid reductase activity
GO:0045174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydroascorbic reductase activity
GO:0045174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione dehydrogenase (ascorbate) activity
REACT:R-RNO-2065355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)
RHEA:20020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 <=> 5,10-methylenetetrahydromethanopterin + H(+)
RHEA:36742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptadecasphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine
RHEA:23809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine + S-adenosyl-L-methionine => (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-5324632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Sus scrofa)
RHEA:40879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-HSA-877281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 binds p-STAT1 dimer (Homo sapiens)
RHEA:32918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycero-3-phospho-1D-myo-inositol(out) <=> sn-glycero-3-phospho-1D-myo-inositol(in)
RHEA:46513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-9708292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DICER1 cleaves tRNA (Homo sapiens)
GO:0009899	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ent-kaurene synthase B activity
GO:0009899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ent-copalyl-diphosphate diphosphate-lyase (cyclizing)
GO:0009899	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)
GO:0009899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaurene synthase activity
GO:0009899	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ent-kaurene synthetase B activity
REACT:R-HSA-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Homo sapiens)
REACT:R-GGA-9624668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDKN1A (p21) (Gallus gallus)
REACT:R-HSA-9608288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MUTYH mutants do not bind adenine mispaired with 8-oxoguanine (Homo sapiens)
EC:3.2.1.n3	skos:prefLabel	"Dictyostelium lysozyme A"
EC:3.2.1.n3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Dictyostelium lysozyme A"
RHEA:28104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose + GDP + H(+) => GDP-alpha-D-mannose + H2O
REACT:R-HSA-9624353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the PLTP gene (Homo sapiens)
RHEA:52873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:26469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-demethylmenaquinone + S-adenosyl-L-methionine <=> a menaquinone + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-417820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 receptor can bind to LPA (Homo sapiens)
REACT:R-DRE-72647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cap-bound mRNA is activated by helicases  (Danio rerio)
REACT:R-XTR-200410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Xenopus tropicalis)
GO:0030296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine kinase activator activity
REACT:R-MTU-879281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycothiol is cleaved to acetylcysteine and glucosaminylinositol (Mycobacterium tuberculosis)
RHEA:67672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate
REACT:R-RNO-5690740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds B-cell receptor (Rattus norvegicus)
REACT:R-HSA-2534346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAM1 Binds Hyaluronic Acid (Homo sapiens)
RHEA:51127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine in snRNA <=> pseudouridine in snRNA
RHEA:36026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DME-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Drosophila melanogaster)
REACT:R-MMU-8987012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)
REACT:R-MMU-449087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD4 binds Interleukin-16 (Mus musculus)
REACT:R-HSA-428534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Profilin by Ena/VASP proteins (Homo sapiens)
RHEA:58921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (+)-medicarpin + H2O
REACT:R-RNO-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)
REACT:R-HSA-4085029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU2 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)
REACT:R-RNO-5687673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN recruits LIG3:XRCC1 to MMEJ sites (Rattus norvegicus)
REACT:R-DRE-8987129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Danio rerio)
RHEA:10726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-6-deoxy-alpha-D-talose + NADP(+)
REACT:R-SSC-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Sus scrofa)
REACT:R-MMU-212710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR activates PLC-gamma1 by phosphorylation (Mus musculus)
RHEA:29636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaose + H2O => alpha-D-glucose + D-maltotetraose
REACT:R-SSC-5159245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Sus scrofa)
REACT:R-RNO-432909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Plectin with Integrin beta 4 (Rattus norvegicus)
RHEA:53870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxyphenazine + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1-carboxylate
RHEA:10006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl thiocyanate => benzyl isothiocyanate
REACT:R-BTA-9708517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Bos taurus)
REACT:R-DME-173512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Drosophila melanogaster)
RHEA:61920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-ketoconazole(in) + ATP + H2O = (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate
REACT:R-HSA-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Homo sapiens)
RHEA:25302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroneopterin triphosphate diphosphatase"
RHEA:25302	skos:altLabel	"dihydroneopterin triphosphate pyrophosphohydrolase"
RHEA:25302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)
RHEA:25302	skos:prefLabel	"dihydroneopterin triphosphate diphosphatase"
RHEA:66705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mycophenolyl-CoA => CoA + H(+) + mycophenolate
RHEA:35384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-6B + S-adenosyl-L-methionine => CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine
RHEA:57214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + methylglyoxal
RHEA:47859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a (d18:1(4E)) + H2O <=> ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate
REACT:R-DME-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Drosophila melanogaster)
REACT:R-XTR-77277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Xenopus tropicalis)
RHEA:32822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromate(in) <=> chromate(out)
REACT:R-GGA-158164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Gallus gallus)
REACT:R-HSA-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Homo sapiens)
RHEA:36316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-CoA + 2 NADPH => CoA + hexadecan-1-ol + 2 NADP(+)
REACT:R-GGA-201634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of FADK 1 (Gallus gallus)
REACT:R-XTR-5607726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Xenopus tropicalis)
REACT:R-XTR-141026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor Va to factor Vi intermediate form (Xenopus tropicalis)
RHEA:26127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + L-proline <=> (S)-1-pyrroline-5-carboxylate + FADH2
REACT:R-HSA-9623415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter (Homo sapiens)
RHEA:58867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CFA-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-MMU-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Mus musculus)
RHEA:14582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 monodehydro-L-ascorbate radical + NADH => 2 L-ascorbate + NAD(+)
RHEA:32126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + H(+)(in) <=> citrate(out) + H(+)(out)
RHEA:20459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinono-1,4-lactone + H(+) + NADH => D-arabinose + NAD(+)
REACT:R-SCE-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Saccharomyces cerevisiae)
RHEA:21996	skos:altLabel	"1-hexadecyl-2-acetylglycerol acyltransferase"
RHEA:21996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA
RHEA:21996	skos:prefLabel	"1-alkyl-2-acetylglycerol O-acyltransferase"
RHEA:21996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-alkyl-2-acetylglycerol O-acyltransferase"
REACT:R-DRE-8953917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Danio rerio)
RHEA:29382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + H2O <=> 2'-deoxyguanosine + phosphate
RHEA:21919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O <=> an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)
REACT:R-HSA-5610725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TULP3 is required for GPR161 localization in the cilium (Homo sapiens)
REACT:R-MMU-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Mus musculus)
REACT:R-XTR-9013109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GEFs activate RHOC (Xenopus tropicalis)
RHEA:55269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (R)-glycerate + alpha-D-glucose 1-phosphate
REACT:R-BTA-174660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Bos taurus)
RHEA:62105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:32028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-alpha-cuprenene + diphosphate
REACT:R-SSC-6814187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVL:PPL heterodimer binds the inner surface of the plasma membrane (Sus scrofa)
RHEA:63301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine
REACT:R-DME-380901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked serotonin loaded synaptic vesicle (Drosophila melanogaster)
RHEA:61952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate
REACT:R-DRE-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Danio rerio)
RHEA:12280	skos:altLabel	"type II PIP kinase"
RHEA:12280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
RHEA:12280	skos:prefLabel	"1-phosphatidylinositol-5-phosphate 4-kinase"
RHEA:12280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-phosphatidylinositol-5-phosphate 4-kinase"
REACT:R-XTR-163090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation Of The Telomeric Chromosome End (Xenopus tropicalis)
RHEA:69044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrobutanedioate = fumarate + H(+) + nitrite
RHEA:61806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-alanyl-5'-AMP => ATP + H(+) + L-alanine
REACT:R-SCE-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Saccharomyces cerevisiae)
RHEA:54691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alliin <=> 2-aminoprop-2-enoate + allylsulfenate
REACT:R-HSA-9702510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT mutants bind type II TKIs (Homo sapiens)
REACT:R-GGA-6806974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET dimers autophosphorylate (Gallus gallus)
RHEA:25323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine => N-methylethanolamine phosphate + S-adenosyl-L-methionine
RHEA:35514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malonate--CoA ligase"
RHEA:32139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + malonate = AMP + diphosphate + malonyl-CoA
RHEA:32139	skos:prefLabel	"malonate--CoA ligase"
RHEA:31253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-2-methylpropanoate + CoA + H(+) => (S)-3-hydroxyisobutanoyl-CoA + H2O
REACT:R-DME-9749609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCHE hydrolyzes ASA- (Drosophila melanogaster)
REACT:R-MMU-351210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Mus musculus)
RHEA:33822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate <=> 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate
RHEA:33972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5''-phosphoribostamycin + H2O => phosphate + ribostamycin
REACT:R-HSA-2032396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)
RHEA:61418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-trans-nepetalactol => (S)-8-oxocitronellyl enol
REACT:R-SPO-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Schizosaccharomyces pombe)
REACT:R-SSC-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)
REACT:R-HSA-9685939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3a localizes to the cell membrane (Homo sapiens)
GO:0015625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent ferric-hydroxamate transmembrane transporter activity
GO:0015625	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	iron-chelate-transporting ATPase activity
GO:0015625	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ferric-hydroxamate porter activity
GO:0015625	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-coupled iron-chelate transporter activity
GO:0015625	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP-dependent iron-chelate transporter activity
GO:0015625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric-hydroxamate-transporting ATPase activity
GO:0015625	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ferric-hydroxamate transmembrane transporter activity
GO:0015625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type ferric hydroxamate transporter activity
GO:0015625	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ferric-hydroxamate ABC transporter
GO:0015625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled ferric-hydroxamate transmembrane transporter activity
GO:0015381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity sulfate transmembrane transporter activity
GO:0015381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity sulphate permease activity
GO:0015381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	high affinity sulfate permease activity
GO:0015381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity sulfate transmembrane transporter activity
REACT:R-MMU-194308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Mus musculus)
RHEA:62788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 fonsecin B + H(+) + NADPH + O2 = aurasperone B + 2 H2O + NADP(+)
REACT:R-SSC-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Sus scrofa)
REACT:R-DDI-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Dictyostelium discoideum)
RHEA:29490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> cis-muurola-3,5-diene + diphosphate
RHEA:25882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+) => 2 L-dopa + O2
REACT:R-CFA-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Canis familiaris)
REACT:R-RNO-174959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT1 (Rattus norvegicus)
REACT:R-HSA-139905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAD protein to mitochondria (Homo sapiens)
REACT:R-BTA-202466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Bcl10 to CARMA1 (Bos taurus)
REACT:R-GGA-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Gallus gallus)
RHEA:52959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyodeoxycholate + UDP-alpha-D-glucuronate <=> hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-MMU-174439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)
RHEA:66822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + Mn(2+)(out) + phosphate => ATP + H2O + Mn(2+)(in)
REACT:R-MMU-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Mus musculus)
RHEA:19613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + trimethylsulfonium
RHEA:19613	skos:prefLabel	"thioether S-methyltransferase"
RHEA:19613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thioether S-methyltransferase"
REACT:R-DDI-9749647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES2 hydrolyzes ASA- (Dictyostelium discoideum)
RHEA:61155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
REACT:R-XTR-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Xenopus tropicalis)
RHEA:36276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NADP(+)
REACT:R-HSA-8848077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAP2 (Homo sapiens)
REACT:R-HSA-380199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)
GO:0102852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:3-2-16:0-phosphatidylglycerol desaturase activity
REACT:R-BTA-1474210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP14 (Bos taurus)
REACT:R-DRE-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Danio rerio)
RHEA:37579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:25789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxoheptanedioate => pyruvate + succinate semialdehyde
REACT:R-BTA-983145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Bos taurus)
RHEA:55116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)
REACT:R-BTA-193668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR and RHOA-GDI interact (Bos taurus)
REACT:R-MMU-8942208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOXE3 isomerises 12R-HpETE to HXA3 (Mus musculus)
RHEA:25121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate = H(+) + H2O + L-1-piperideine-6-carboxylate
RHEA:30900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP
GO:0016679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on diphenols and related substances as donors
GO:0016679	skos:prefLabel	"Acting on diphenols and related substances as donors"
GO:0016679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on diphenols and related substances as donors"
GO:0016679	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors
RHEA:35682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + L-serine <=> 3-oxotetradecasphinganine + CO2 + CoA
RHEA:21867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-(2-hydroxyacyl)glutathione + H2O <=> a 2-hydroxy carboxylate + glutathione + H(+)
RHEA:56574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + H(+) + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose
RHEA:15191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 Fe(II)-[cytochrome c553] + H(+) => 2 Fe(III)-[cytochrome c553] + formate
REACT:R-RNO-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)
REACT:R-XTR-9009554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer:SDC1 binds CSF1R (Xenopus tropicalis)
GO:0008396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxysterol 7-alpha-hydroxylase activity
GO:0008396	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP7B1
RHEA:55593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (3R)-hydroxydecanoyl-[ACP] + H2O => (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]
RHEA:16926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + S-adenosyl-L-methionine => (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Bos taurus)
REACT:R-BTA-391378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follicle-stimulating hormone receptor can bind FSH (Bos taurus)
RHEA:15436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + dimethylallyl diphosphate <=> diphosphate + sophoraflavanone B
REACT:R-DRE-937034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino (Danio rerio)
REACT:R-DDI-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Dictyostelium discoideum)
RHEA:29328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + succinate(out) => (S)-malate(out) + succinate(in)
REACT:R-MMU-5195402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LPIN (Mus musculus)
REACT:R-RNO-429567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Rattus norvegicus)
REACT:R-SSC-202710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MERTK receptor binds ligands (Gas6 or Protein S) (Sus scrofa)
RHEA:19474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + H(+) + NADH + O2 => 3,4-dihydroxybenzoate + H2O + NAD(+)
REACT:R-BTA-187828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p21 to the nucleus (Bos taurus)
REACT:R-RNO-8862700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMKLR1 binds Resolvin E1 (Rattus norvegicus)
REACT:R-BTA-8853419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 promotes AURKA autophosphorylation (Bos taurus)
REACT:R-HSA-4655431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOyation of DNMT1 with SUMO1 (Homo sapiens)
RHEA:57035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O <=> CO2 + formate + methylamine + succinate semialdehyde
REACT:R-SPO-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Schizosaccharomyces pombe)
RHEA:72628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + Zn(2+)(in) => 2 H(+)(in) + Zn(2+)(out)
RHEA:44196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylundecanoate + ATP + CoA = 3-methylundecanoyl-CoA + AMP + diphosphate
REACT:R-BTA-5665761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL3 binds RHOC:GTP (Bos taurus)
REACT:R-MMU-6786034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Mus musculus)
REACT:R-CEL-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)
REACT:R-HSA-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Homo sapiens)
RHEA:28131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baicalin + H2O => baicalein + D-glucuronate + H(+)
REACT:R-DRE-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Danio rerio)
REACT:R-DME-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)
REACT:R-HSA-9012542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Homo sapiens)
RHEA:41772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) = CMP + ganglioside GQ1b (d18:1(4E)) + H(+)
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choloyl coenzyme A synthetase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity
GO:0047747	skos:altLabel	"cholate thiokinase"
GO:0047747	skos:altLabel	"bile acid CoA ligase"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BAL activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholate thiokinase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity
GO:0047747	skos:altLabel	"cholyl-CoA synthetase"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choloyl-CoA synthetase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate-CoA ligase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholyl-CoA synthetase activity
GO:0047747	skos:altLabel	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholate--CoA ligase"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)
GO:0047747	skos:altLabel	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate--CoA ligase"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trihydroxycoprostanoyl-CoA synthetase activity
GO:0047747	skos:altLabel	"BAL"
GO:0047747	skos:prefLabel	"cholate--CoA ligase"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity
GO:0047747	skos:altLabel	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholic acid:CoA ligase activity
GO:0047747	skos:altLabel	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	THCA-CoA ligase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bile acid coenzyme A ligase activity
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholate:CoA ligase (AMP-forming)
GO:0047747	skos:altLabel	"cholic thiokinase"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity
GO:0047747	skos:altLabel	"trihydroxycoprostanoyl-CoA synthetase"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholic thiokinase activity
GO:0047747	skos:altLabel	"THCA-CoA ligase"
GO:0047747	skos:altLabel	"choloyl coenzyme A synthetase"
GO:0047747	skos:altLabel	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase"
GO:0047747	skos:altLabel	"bile acid coenzyme A ligase"
GO:0047747	skos:altLabel	"cholic acid:CoA ligase"
GO:0047747	skos:altLabel	"choloyl-CoA synthetase"
GO:0047747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bile acid CoA ligase activity
RHEA:70226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + 2-oxoglutarate <=> 2-oxobutanoate + L-glutamate
RHEA:33900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose => FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose
REACT:R-GGA-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Gallus gallus)
REACT:R-HSA-5250600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botD:SV2:GD2 internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
REACT:R-XTR-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Xenopus tropicalis)
REACT:R-BTA-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Bos taurus)
REACT:R-BTA-8849068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARHGAP35 (Bos taurus)
REACT:R-SSC-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Sus scrofa)
EC:3.4.13.5	skos:altLabel	"anserinase"
EC:3.4.13.5	skos:altLabel	"aminoacyl-methylhistidine dipeptidase"
EC:3.4.13.5	skos:prefLabel	"Xaa-methyl-His dipeptidase"
EC:3.4.13.5	skos:altLabel	"X-methyl-His dipeptidase"
EC:3.4.13.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Xaa-methyl-His dipeptidase"
REACT:R-HSA-5654167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds PLCG1 (Homo sapiens)
RHEA:70284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylputrescine + O2 => 4-acetamidobutanal + H2O2 + NH4(+)
REACT:R-HSA-8938022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds the NR4A3 gene promoter (Homo sapiens)
RHEA:51837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
RHEA:45754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA => (3E)-decenoyl-CoA
REACT:R-SSC-2045911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
REACT:R-RNO-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Rattus norvegicus)
REACT:R-HSA-8938887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML binds RUNX1 (Homo sapiens)
RHEA:26298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O
REACT:R-RNO-9700998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 disrupts the BRCA1:BARD1 heterodimer (Rattus norvegicus)
GO:0050549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isonitrile hydratase activity
GO:0050549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)
GO:0050549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-cyclohexylformamide hydro-lyase activity
GO:0050549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexyl-isocyanide hydratase activity
RHEA:35265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O
REACT:R-BTA-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Bos taurus)
RHEA:37597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA
REACT:R-GGA-211164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO1A (Gallus gallus)
REACT:R-CFA-3318486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Canis familiaris)
REACT:R-BTA-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Bos taurus)
RHEA:20778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + stachyose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose
REACT:R-SCE-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Saccharomyces cerevisiae)
RHEA:27585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxymethylglutarate <=> 2-methyleneglutarate + H2O
REACT:R-MMU-8877902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated AR binds RUNX2 (Mus musculus)
RHEA:58433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-oxonon-2-en-1-ol + NADP(+) => (E)-4-oxonon-2-enal + H(+) + NADPH
REACT:R-HSA-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Homo sapiens)
REACT:R-HSA-9613202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1 and NAB co-repressors bind EGR1 gene (Homo sapiens)
RHEA:22187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) <=> acenaphthene-1,2-dione + 2 H(+) + 2 NADPH
GO:0031803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 6 metabotropic glutamate receptor binding
GO:0031803	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 6 metabotropic glutamate receptor ligand
REACT:R-SSC-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Sus scrofa)
RHEA:39619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH = (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)
REACT:R-HSA-5654634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates SHC1 (Homo sapiens)
REACT:R-HSA-5685208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCDC59:TTF1 binds SFTPB gene (Homo sapiens)
REACT:R-RNO-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)
REACT:R-DME-209057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
REACT:R-CEL-5205799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Caenorhabditis elegans)
REACT:R-XTR-5340195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4 binds DCA, CDCA, LCHA (Xenopus tropicalis)
RHEA:35813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-medicarpin + H2O => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol
REACT:R-CFA-5660663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 cleaves IL1B precursor (Canis familiaris)
RHEA:66191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP(in) + ATP + H2O <=> 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate
REACT:R-RNO-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Rattus norvegicus)
RHEA:18158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyruvate => ADP + H(+) + phosphoenolpyruvate
REACT:R-HSA-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)
RHEA:71690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-aspartate(out) + 2 H(+)(out) <=> glycyl-L-aspartate(in) + 2 H(+)(in)
RHEA:18415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose
REACT:R-CFA-9706393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds ATP (Canis familiaris)
REACT:R-HSA-2972952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), NANOG bind the GATA6 promoter (Homo sapiens)
RHEA:38275	skos:prefLabel	"(R)-citramalyl-CoA lyase"
RHEA:38275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalyl-CoA = acetyl-CoA + pyruvate
RHEA:38275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-citramalyl-CoA lyase"
GO:0016848	skos:prefLabel	"Carbon-halide lyases"
GO:0016848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carbon-halide lyases"
GO:0016848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-halide lyase activity
RHEA:13991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose
RHEA:60998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-leucine + O2
REACT:R-DME-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Drosophila melanogaster)
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl-ATP diphosphorylase activity
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl-ATP pyrophosphorylase activity
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ATP phosphoribosyltransferase"
GO:0003879	skos:altLabel	"phosphoribosyl-ATP pyrophosphorylase"
GO:0003879	skos:altLabel	"phosphoribosyl-ATP diphosphorylase"
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl ATP synthetase activity
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP phosphoribosyltransferase activity
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyladenosine triphosphate synthetase activity
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
GO:0003879	skos:prefLabel	"ATP phosphoribosyltransferase"
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine triphosphate phosphoribosyltransferase activity
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyladenosine triphosphate pyrophosphorylase activity
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity
GO:0003879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity
REACT:R-SSC-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Sus scrofa)
RHEA:62798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurasperone A + 2 H2O + NADP(+) => H(+) + NADPH + O2 + 2 rubrofusarin B
REACT:R-CEL-8952062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 recruits HDAC4 to RUNX3 (Caenorhabditis elegans)
REACT:R-DRE-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Danio rerio)
REACT:R-DRE-5654402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
RHEA:58767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)
RHEA:62028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + stigmasteryl 3-beta-D-glucoside = D-glucose + stigmasterol
REACT:R-XTR-5628905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Xenopus tropicalis)
REACT:R-SCE-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Saccharomyces cerevisiae)
REACT:R-DRE-9708558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Danio rerio)
REACT:R-HSA-381487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP1 binds IGF forming IGF:IGFBP1 (Homo sapiens)
RHEA:33501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 => H(+) + prephenate
RHEA:11820	skos:altLabel	"mono(ADP-ribosyl)transferase"
RHEA:11820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(+)--diphthamide ADP-ribosyltransferase"
RHEA:11820	skos:altLabel	"ADP-ribosyltransferase"
RHEA:11820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthamide-[translation elongation factor 2] + NAD(+) = H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide
RHEA:11820	skos:prefLabel	"NAD(+)--diphthamide ADP-ribosyltransferase"
RHEA:59144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate
REACT:R-BTA-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Bos taurus)
RHEA:11462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + D-glucose 6-phosphate + H(+) => ADP + D-glucose
RHEA:72377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(in) + iodide(out) => hydrogencarbonate(out) + iodide(in)
REACT:R-PFA-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Plasmodium falciparum)
RHEA:23090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkylglycerone 3-phosphate + ADP + H(+) => ATP + O-alkylglycerone
RHEA:31177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxyisobutanoyl-CoA => (2E)-2-methylpropenoyl-CoA + H2O
REACT:R-MMU-1497869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - Sepiapterin is reduced to BH2 (Mus musculus)
RHEA:12814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate => D-glutamate
RHEA:60062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose
REACT:R-HSA-210886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEUROG3-dependent synthesis of PAX4 protein (Homo sapiens)
RHEA:40933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-ornithine + CO2 + succinate => 2-oxoglutarate + L-ornithine + O2
GO:0140954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36 mono/dimethylase activity
GO:0140954	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K36 dimethylation
GO:0140954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-dimethyltransferase activity (H3-K36 specific)
GO:0140954	skos:prefLabel	"[histone H3]-lysine(36) N-dimethyltransferase"
GO:0140954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36 dimethylase activity
GO:0140954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine
GO:0140954	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K36 dimethylation
GO:0140954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(36) N-dimethyltransferase"
GO:0140954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36 dimethyltransferase activity
RHEA:51866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-geranylesculetin + diphosphate => (2E)-geranyl diphosphate + esculetin
GO:0004446	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	multiple inositol-polyphosphate phosphatase activity
GO:0004446	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity
GO:0004446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-hexakisphosphate phosphatase activity
GO:0004446	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	MIPP activity
GO:0004446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol tetrakisphosphate phosphomonoesterase activity
REACT:R-MMU-1297338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of ADAM and B4GALT1 With ZP3 (Mus musculus)
REACT:R-XTR-2162226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Xenopus tropicalis)
REACT:R-CEL-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Caenorhabditis elegans)
RHEA:41108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate
REACT:R-DRE-211962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F11 16-hydroxylates 3OH-PALM (Danio rerio)
RHEA:64973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP + H2O => dUMP + H(+) + phosphate
REACT:R-MMU-6806647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Mus musculus)
REACT:R-DRE-2130393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex along Golgi to TGN (Danio rerio)
REACT:R-SCE-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Saccharomyces cerevisiae)
RHEA:31409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diapolycopene + FADH2 => all-trans-4,4'-diaponeurosporene + FAD + H(+)
REACT:R-XTR-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Xenopus tropicalis)
REACT:R-GGA-418082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of telomerase RNP from the extended chromosomal end (Gallus gallus)
RHEA:16496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 1,2-cyclic phosphate + H2O <=> glycerol 1-phosphate + H(+)
REACT:R-HSA-212263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 trimethylates histone H3 at lysine-27 (Homo sapiens)
REACT:R-RNO-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Rattus norvegicus)
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminolevulinic acid synthase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-aminolevulinic acid synthase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminolevulinic acid synthase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate synthase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-aminolevulinate synthetase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminolevulinic acid synthetase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-ALA synthetase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminolevulinic acid synthetase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-aminolevulinic acid synthetase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-aminolevulinate synthase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ALAS activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminolevulinate synthetase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-aminolevulinic acid synthase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminolevulinic synthetase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ALA synthase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ALA synthetase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminolevulinate synthase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-aminolevulinic synthetase activity
GO:0003870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminolevulinate synthetase activity
GO:0140441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]
GO:0140441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-cysteine S-arachidonoyltransferase activity
REACT:R-MMU-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Mus musculus)
REACT:R-XTR-4341048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RXRA with SUMO1 (Xenopus tropicalis)
REACT:R-CFA-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Canis familiaris)
GO:0102440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5'-trimethylmyricetin 3-O-methyltransferase activity
REACT:R-RNO-9706330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS6 (Rattus norvegicus)
RHEA:70759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-5683888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMCD1 binds GATA6, sequestering it (Rattus norvegicus)
RHEA:34560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11beta-hydroxypentalenate + NAD(+) => 1-deoxy-11-oxopentalenate + H(+) + NADH
GO:0031700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	adrenomedullin receptor ligand
GO:0031700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenomedullin receptor binding
REACT:R-HSA-870437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)
RHEA:22358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + phosphate + phosphoenolpyruvate => diphosphate + oxaloacetate
RHEA:54947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)
RHEA:22343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + NADP(+) <=> 3-hydroxybenzaldehyde + H(+) + NADPH
RHEA:32257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+) => meso-2,6-diaminoheptanedioate + NADP(+)
REACT:R-PFA-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
REACT:R-DME-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Drosophila melanogaster)
RHEA:56041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
RHEA:51588	skos:prefLabel	"isopyridoxal dehydrogenase (5-pyridoxolactone-forming)"
RHEA:51588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopyridoxal dehydrogenase (5-pyridoxolactone-forming)"
RHEA:51588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopyridoxal + NAD(+) = 5-pyridoxolactone + H(+) + NADH
REACT:R-DRE-375768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Danio rerio)
GO:0140398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	versicolorin B desaturase activity
RHEA:31543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 UDP-alpha-D-glucose = 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)
RHEA:31543	skos:prefLabel	"zeaxanthin glucosyltransferase"
RHEA:31543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zeaxanthin glucosyltransferase"
REACT:R-BTA-8987255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Bos taurus)
REACT:R-HSA-9661446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMG, BDG translocates from ER lumen to cytosol (Homo sapiens)
REACT:R-HSA-202325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Gads to LAT (Homo sapiens)
RHEA:58084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(13Z-docosenoyl)-glycerol + H2O = (13Z)-docosenoate + glycerol + H(+)
REACT:R-CFA-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
EC:2.6.1.14	skos:altLabel	"asparagine--oxo-acid aminotransferase"
EC:2.6.1.14	skos:prefLabel	"asparagine--oxo-acid transaminase"
EC:2.6.1.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"asparagine--oxo-acid transaminase"
RHEA:58604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 H(+) + NADH + O2 = FADH2-C4alpha-hydroperoxide + NAD(+)
RHEA:37347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + ATP + D-alanine = ADP + D-alanyl-(R)-lactate + phosphate
RHEA:37347	skos:prefLabel	"D-alanine--(R)-lactate ligase"
RHEA:37347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-alanine--(R)-lactate ligase"
GO:0072541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxynitrite reductase activity
GO:0072541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxynitritase activity
RHEA:17863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-3-oxopregn-4-en-21-al => 21-hydroxyprogesterone
RHEA:18498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose 5-phosphate => L-xylulose 5-phosphate
RHEA:43928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pregn-5-ene-3,20-dione = progesterone
REACT:R-RNO-2473594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP15 (Rattus norvegicus)
REACT:R-BTA-8987156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Bos taurus)
RHEA:25034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + NADP(+) => all-trans-retinal + H(+) + NADPH
REACT:R-DRE-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Danio rerio)
REACT:R-SSC-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Sus scrofa)
REACT:R-GGA-9009485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34:CSF1 binds CSF1R (Gallus gallus)
GO:0072586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity
REACT:R-MMU-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Mus musculus)
RHEA:42563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(27/28) in mitochondrial tRNA <=> pseudouridine(27/28) in mitochondrial tRNA
REACT:R-PFA-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Plasmodium falciparum)
REACT:R-CEL-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Caenorhabditis elegans)
REACT:R-DME-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Drosophila melanogaster)
REACT:R-DRE-9020271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Danio rerio)
REACT:R-HSA-418856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 (Homo sapiens)
REACT:R-HSA-981535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) binds C3bBb, C4bC2a (Homo sapiens)
REACT:R-GGA-5654425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds SHC1 (Gallus gallus)
REACT:R-HSA-9005980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 binds IL21R:JAK1 (Homo sapiens)
REACT:R-HSA-9694338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp1-4 cleaves itself (Homo sapiens)
REACT:R-SCE-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Saccharomyces cerevisiae)
REACT:R-HSA-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Homo sapiens)
RHEA:42791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-5625029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:35187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-aminoperacrylic acid + AH2 = (Z)-3-aminoacrylate + A + H(+) + H2O
REACT:R-BTA-9706340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y-GRB10 binds PIK3R1 (Bos taurus)
RHEA:48014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite => 4-methyl-5-nitrocatechol + NADPH + O2
REACT:R-RNO-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Rattus norvegicus)
RHEA:27959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + H2O => cytosine + D-ribose
RHEA:19680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9'-cis-neoxanthin + O2 <=> (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin
RHEA:59337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-all-trans-1,2-dihydro-neurosporene + A => AH2 + demethylspheroidene
REACT:R-SSC-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Sus scrofa)
REACT:R-XTR-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Xenopus tropicalis)
REACT:R-DME-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Drosophila melanogaster)
REACT:R-BTA-109857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 binds MAPK3 (Bos taurus)
REACT:R-HSA-9653742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF4 and a CEBP protein bind the ATF5 promoter (Homo sapiens)
RHEA:62202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => ethanol + 2 Fe(III)-[cytochrome c]
RHEA:68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxycoumarin + S-adenosyl-L-methionine = 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine
RHEA:23803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionine <=> 2-oxobutanoate + methanethiol + NH4(+)
REACT:R-BTA-112381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Bos taurus)
RHEA:11744	skos:prefLabel	"thiamine-triphosphatase"
RHEA:11744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiamine-triphosphatase"
RHEA:11744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate
RHEA:11744	skos:altLabel	"ThTPase"
RHEA:10105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A20 + O2 => CO2 + gibberellin A1 + succinate
RHEA:54966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl phosphate + holo-[ACP] => hexadecanoyl-[ACP] + phosphate
REACT:R-HSA-8849797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)
GO:0016832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Aldehyde-lyases"
GO:0016832	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aldolase activity
GO:0016832	skos:prefLabel	"Aldehyde-lyases"
GO:0016832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde-lyase activity
RHEA:32148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sepiapterin => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)
RHEA:58250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + H(+) + L-glutamyl-[protein] => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O
REACT:R-DME-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Drosophila melanogaster)
REACT:R-HSA-216040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)
REACT:R-RNO-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Rattus norvegicus)
RHEA:29487	skos:prefLabel	"cis-muuroladiene synthase"
RHEA:29487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-muuroladiene synthase"
RHEA:29487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = cis-muurola-4(14),5-diene + diphosphate
RHEA:29487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = cis-muurola-3,5-diene + diphosphate
RHEA:61321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide
REACT:R-DDI-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Dictyostelium discoideum)
RHEA:47290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-1306965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Bos taurus)
REACT:R-DME-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Drosophila melanogaster)
RHEA:37362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucosamine 6-phosphate(in) + L-histidyl-[protein]
REACT:R-MMU-5687675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates remaining SSBs in MMEJ (Mus musculus)
RHEA:11092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH
RHEA:11092	skos:altLabel	"hydroglycerophosphate dehydrogenase"
RHEA:11092	skos:altLabel	"glycerol phosphate dehydrogenase (NAD)"
RHEA:11092	skos:altLabel	"NAD-dependent glycerol phosphate dehydrogenase"
RHEA:11092	skos:altLabel	"glycerol 1-phosphate dehydrogenase"
RHEA:11092	skos:altLabel	"L-glycerol phosphate dehydrogenase"
RHEA:11092	skos:altLabel	"L-alpha-glycerophosphate dehydrogenase"
RHEA:11092	skos:altLabel	"L-alpha-glycerol phosphate dehydrogenase"
RHEA:11092	skos:altLabel	"glycerol-3-phosphate dehydrogenase (NAD)"
RHEA:11092	skos:altLabel	"NAD-L-glycerol-3-phosphate dehydrogenase"
RHEA:11092	skos:altLabel	"alpha-glycerol phosphate dehydrogenase (NAD)"
RHEA:11092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-3-phosphate dehydrogenase (NAD(+))"
RHEA:11092	skos:altLabel	"NAD-dependent glycerol-3-phosphate dehydrogenase"
RHEA:11092	skos:altLabel	"L-glycerophosphate dehydrogenase"
RHEA:11092	skos:prefLabel	"glycerol-3-phosphate dehydrogenase (NAD(+))"
RHEA:11092	skos:altLabel	"alpha-glycerophosphate dehydrogenase (NAD)"
RHEA:11092	skos:altLabel	"NADH-dihydroxyacetone phosphate reductase"
RHEA:11092	skos:altLabel	"NAD-alpha-glycerophosphate dehydrogenase"
RHEA:11092	skos:altLabel	"NAD-linked glycerol 3-phosphate dehydrogenase"
RHEA:11092	skos:altLabel	"L-glycerol-3-phosphate dehydrogenase"
RHEA:11092	skos:altLabel	"glycerophosphate dehydrogenase (NAD)"
RHEA:44791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-11 + S-adenosyl-L-methionine <=> H(+) + menaquinol-11 + S-adenosyl-L-homocysteine
REACT:R-XTR-3000122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD320 binds extracellular TCN2:RCbl (Xenopus tropicalis)
RHEA:51298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + L-methionyl-(R)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]
REACT:R-MMU-8853745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA3 (Mus musculus)
GO:0140610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA sequestering activity
REACT:R-HSA-76060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Promoter Opening at Type 1 Promoters (Homo sapiens)
REACT:R-MMU-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Mus musculus)
GO:0034578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene 8-hydratase activity
GO:0102734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brassinolide synthase activity
RHEA:38347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-3,5-dihydroxyphenylglycine transaminase"
RHEA:38347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate
RHEA:38347	skos:prefLabel	"(S)-3,5-dihydroxyphenylglycine transaminase"
REACT:R-HSA-5617412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)
RHEA:62664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'R)-atrovenetin + S-adenosyl-L-methionine = deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine
RHEA:72119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + glycine betaine(out) = (R)-carnitine(out) + glycine betaine(in)
REACT:R-MMU-6784734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds LDLR (Mus musculus)
RHEA:70653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein] => (9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein]
REACT:R-CFA-399936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of integrin activation by sequestering PIP5KIgamma (Canis familiaris)
REACT:R-BTA-9033527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Bos taurus)
RHEA:58345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->3)-O-lithocholate + H2O => D-glucose + lithocholate
REACT:R-DRE-9669893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type I TKIs (Danio rerio)
REACT:R-HSA-8874789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds the EGFR gene promoter (Homo sapiens)
GO:0061898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans retinoic acid 3,4-desaturase activity
REACT:R-DDI-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Dictyostelium discoideum)
REACT:R-XTR-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Xenopus tropicalis)
RHEA:37913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol
REACT:R-SSC-8862771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G2A binds bacterial phospholipids (Sus scrofa)
REACT:R-BTA-3968414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Bos taurus)
RHEA:57257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + H(+) + lactate
RHEA:21090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol + CO2 + H2O + succinate => 2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2
GO:0015314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminotriazole:hydrogen antiporter activity
GO:0015314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminotriazole:proton antiporter activity
REACT:R-RNO-9650473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 is secreted (Rattus norvegicus)
RHEA:37779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-CEL-450984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Caenorhabditis elegans)
GO:0102234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	but-1-en-3-one reductase activity
RHEA:23813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-neomenthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH
RHEA:45001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 3-hydroxybutanoyl-CoA => CoA + O-3-hydroxybutanoyl-(R)-carnitine
REACT:R-SSC-205306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP1 and KIT (Sus scrofa)
REACT:R-XTR-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Xenopus tropicalis)
REACT:R-RNO-9012315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Rattus norvegicus)
GO:0051269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-keto ester reductase activity
GO:0050040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lactate-2-monooxygenase activity
GO:0050040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactic oxygenase activity
GO:0050040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactic oxidase activity
GO:0050040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactate oxidative decarboxylase activity
GO:0050040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)
GO:0050040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate 2-monooxygenase activity
GO:0050040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactate oxidase activity
GO:0050040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lactate monooxygenase activity
GO:0050040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactate oxygenase activity
GO:0050040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactate monooxygenase activity
RHEA:17310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenyl acetate + H2O => a phenol + acetate + H(+)
RHEA:25169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexan-6-olide => 6-oxohexanoate + H(+)
RHEA:12823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + D-glyceraldehyde 3-phosphate => 2-deoxy-D-ribose 5-phosphate
REACT:R-MMU-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Mus musculus)
REACT:R-MMU-201425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Mus musculus)
RHEA:39789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-975156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex  (Homo sapiens)
RHEA:15614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + precorrin-2 => 2 H(+) + NADH + sirohydrochlorin
REACT:R-RNO-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)
REACT:R-RNO-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Rattus norvegicus)
RHEA:52555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-erythronate + ATP <=> 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)
RHEA:32748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine(in) => ethanolamine(out)
REACT:R-DME-8854905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Drosophila melanogaster)
REACT:R-HSA-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)
REACT:R-GGA-622325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)
RHEA:54049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => 4-epi-cubebol + diphosphate
REACT:R-BTA-8986985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Bos taurus)
REACT:R-DRE-8847638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Danio rerio)
GO:0070915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA receptor activity
GO:0070915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophosphatidic acid receptor activity
REACT:R-HSA-9023983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18(R)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)
REACT:R-CFA-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)
RHEA:18871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-xylulose 5-phosphate => ATP + L-xylulose
REACT:R-RNO-9603984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Rattus norvegicus)
RHEA:68857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate
REACT:R-SSC-9012761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI binds RHOA-GDI (Sus scrofa)
REACT:R-HSA-443986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor ACKR2 binds most inflammatory CC chemokines (Homo sapiens)
RHEA:12966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-galacturonate => 1-phospho-alpha-D-galacturonate + ADP + H(+)
RHEA:42469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + salicylate
REACT:R-DME-8954110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1:EPC1 binds the PRC2 complex (Drosophila melanogaster)
REACT:R-DRE-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Danio rerio)
REACT:R-SSC-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
REACT:R-MMU-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Mus musculus)
GO:0047947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylacetyl-CoA:L-glutamine N-acetyltransferase activity
GO:0047947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine N-phenylacetyltransferase activity
GO:0047947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity
GO:0047947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine phenylacetyltransferase activity
RHEA:13546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] => (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:51241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-GGA-5682893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12:ATG7:CysO572-ATG7 binds ATG10 (Gallus gallus)
RHEA:58279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 ATP <=> cyclic hexaadenylate + 6 diphosphate
REACT:R-DRE-5654641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)
RHEA:68571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(5)-hydroxy-L-ornithine <=> (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O
RHEA:66010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen]
REACT:R-MMU-209921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoiodinated tyrosine can be deiodinated (Mus musculus)
RHEA:65879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androst-1-ene-3,17-dione + H2O <=> 1-hydroxy-5alpha-androstan-3,17-dione
RHEA:59586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-alanyl-L-lysine + H(+) + phosphate => ATP + beta-alanine + L-lysine
REACT:R-GGA-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Gallus gallus)
REACT:R-RNO-9696266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds effectors (Rattus norvegicus)
RHEA:48621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
REACT:R-CFA-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Canis familiaris)
RHEA:35414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside <=> an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)
RHEA:38086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
GO:0016730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on iron-sulphur proteins as donors
GO:0016730	skos:prefLabel	"Acting on iron-sulfur proteins as donors"
GO:0016730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on iron-sulfur proteins as donors"
GO:0016730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on iron-sulfur proteins as donors
RHEA:61213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucoside + UDP
REACT:R-DME-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Drosophila melanogaster)
RHEA:46635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)
REACT:R-DME-374673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds RanBPM (Drosophila melanogaster)
REACT:R-RNO-5654729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Rattus norvegicus)
RHEA:49179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine
RHEA:30336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + H2O => NH4(+) + UTP
RHEA:62708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoate + UDP-alpha-D-glucose = 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP
EC:4.2.3.198	skos:prefLabel	"alpha-selinene synthase"
EC:4.2.3.198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-selinene synthase"
GO:0102982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-3-dehydro-alpha-D-glucose dehydrogenase activity
RHEA:60671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-chrysanthemol + NAD(+) <=> (1R,3R)-chrysanthemal + H(+) + NADH
REACT:R-PFA-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Plasmodium falciparum)
REACT:R-HSA-2186643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
REACT:R-HSA-199169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC Class I interacts with CD160 (Homo sapiens)
REACT:R-BTA-432143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM-1 binds PP2A (Bos taurus)
REACT:R-HSA-5617486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB2 gene is transcribed (Homo sapiens)
RHEA:72531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + methyl beta-D-galactoside(out) = ADP + H(+) + methyl beta-D-galactoside(in) + phosphate
REACT:R-BTA-8948230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P3HB binds 4-Hyp-collagen propeptides (Bos taurus)
REACT:R-BTA-5334794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABPs bind LCFAs (Bos taurus)
RHEA:41725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-4551727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)
RHEA:55242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+) => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O
RHEA:38365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + octadecanoate => 1-octadecanoylglycerol + H2O
RHEA:66860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + 4 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate
REACT:R-SSC-193052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione isomerizes to progesterone (Sus scrofa)
RHEA:36111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A1 + S-adenosyl-L-methionine = O-methyl gibberellin A1 + S-adenosyl-L-homocysteine
REACT:R-DME-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Drosophila melanogaster)
GO:1903875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone binding
RHEA:55779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate <=> 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP
REACT:R-XTR-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Xenopus tropicalis)
REACT:R-MMU-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Mus musculus)
RHEA:42351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)
RHEA:19618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:59951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin F2alpha-CoA <=> CoA + H(+) + prostaglandin F2alpha
REACT:R-MMU-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Mus musculus)
REACT:R-CFA-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Canis familiaris)
REACT:R-SSC-8866304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL binds lipids to form VLDL (Sus scrofa)
RHEA:11301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-5-O-methyl-myo-inositol + NAD(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH
REACT:R-DME-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Drosophila melanogaster)
RHEA:52958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopamine-B-hydroxylase activity
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopamine hydroxylase activity
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxygenase, dopamine beta-mono-
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopamine beta-hydroxylase activity
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MDBH (membrane-associated dopamine beta-monooxygenase)
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxyphenethylamine beta-oxidase activity
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(2-aminoethyl)pyrocatechol beta-oxidase activity
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopa beta-hydroxylase activity
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylamine beta-hydroxylase activity
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SDBH (soluble dopamine beta-monooxygenase)
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine beta-monooxygenase activity
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine b-hydroxylase activity
GO:0004500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopamine beta-oxidase activity
GO:0033691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialic acid binding
GO:0033691	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	N-acetylneuraminic acid binding
REACT:R-BTA-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Bos taurus)
RHEA:36580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-fucose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH
REACT:R-MMU-1067659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of hexameric IL-6 receptor (Mus musculus)
REACT:R-MMU-8857549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HBEGF-bound EGFR forms a heterodimer with GPNMB (Mus musculus)
GO:0044014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2BK5 acetyltransferase activity
GO:0044014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H2B-K5 specific)
GO:0044014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H2B-K5 specific)
GO:0044014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H2B-K5 specific)
REACT:R-GGA-9624800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LBR (Gallus gallus)
REACT:R-DRE-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Danio rerio)
REACT:R-RNO-5690250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Rattus norvegicus)
RHEA:38738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol
GO:0005248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium channel activity
GO:0005248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-sensitive sodium channel
GO:0005248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated sodium ion channel activity
GO:0005248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent sodium channel activity
GO:0005248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage gated sodium channel activity
GO:0005248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:30682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose + H2O <=> beta-D-glucose + D-glucose
RHEA:54147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 <=> 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate
REACT:R-DRE-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
REACT:R-DRE-8939688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) complex binds RUNX2 (Danio rerio)
REACT:R-XTR-5665989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIAPH1 binds RHOA:GTP (Xenopus tropicalis)
REACT:R-BTA-5218811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO binds CRK (Bos taurus)
REACT:R-GGA-196026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dab2 is recruited to the junctional plaques (Gallus gallus)
REACT:R-CFA-2514790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by MMP14 (Canis familiaris)
REACT:R-CEL-8956365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Caenorhabditis elegans)
GO:2001082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inulin binding
RHEA:12335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Fe(3+)(out) + H2O <=> ADP + Fe(3+)(in) + H(+) + phosphate
REACT:R-BTA-159803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Bos taurus)
REACT:R-SSC-6799977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 hydrolyzes bacterial peptidoglycan (Sus scrofa)
REACT:R-BTA-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Bos taurus)
REACT:R-HSA-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Homo sapiens)
GO:0140561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-domain serine glucosyltransferase activity
REACT:R-RNO-4084982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Rattus norvegicus)
RHEA:13730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD => AMP + H(+) + riboflavin cyclic-4',5'-phosphate
REACT:R-CFA-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Canis familiaris)
RHEA:27572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-alpha-D-manno-heptose 7-phosphate
REACT:R-HSA-8852481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Homo sapiens)
REACT:R-GGA-202489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of Bcl10 (Gallus gallus)
REACT:R-MMU-2730844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GRB2:SOS complex with p-SHC1 (Mus musculus)
REACT:R-MMU-9653514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17L2 deubiquitinates RCE1 (Mus musculus)
REACT:R-HSA-9009282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates RUNX2 (Homo sapiens)
REACT:R-RNO-1470012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus (Rattus norvegicus)
RHEA:34344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone
REACT:R-CFA-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Canis familiaris)
REACT:R-CFA-9615249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBs bind AGRT1 (Canis familiaris)
RHEA:34710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane
RHEA:39709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA(in) => a long-chain fatty acyl-CoA(out)
REACT:R-DRE-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Danio rerio)
REACT:R-HSA-2213241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of nonameric complex (Homo sapiens)
REACT:R-CFA-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Canis familiaris)
REACT:R-CFA-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Canis familiaris)
REACT:R-CFA-177934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR autophosphorylation (Canis familiaris)
REACT:R-MMU-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Mus musculus)
REACT:R-CEL-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Caenorhabditis elegans)
RHEA:54902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + NAD(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADH
RHEA:49156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Rattus norvegicus)
RHEA:28307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
EC:2.4.1.100	skos:altLabel	"1,2-beta-fructan 1(F)-fructosyltransferase"
EC:2.4.1.100	skos:prefLabel	"2,1-fructan:2,1-fructan 1-fructosyltransferase"
EC:2.4.1.100	skos:altLabel	"fructan:fructan fructosyl transferase"
EC:2.4.1.100	skos:altLabel	"1,2-beta-D-fructan 1(F)-fructosyltransferase"
EC:2.4.1.100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,1-fructan:2,1-fructan 1-fructosyltransferase"
EC:2.4.1.100	skos:altLabel	"FFT"
EC:2.4.1.100	skos:altLabel	"1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase"
REACT:R-GGA-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Gallus gallus)
REACT:R-HSA-5632892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates transcription of RRM2B gene (Homo sapiens)
RHEA:52206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Gallus gallus)
REACT:R-DME-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Drosophila melanogaster)
REACT:R-HSA-447246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F (Homo sapiens)
REACT:R-DME-9674529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds to TBXA2R (Drosophila melanogaster)
RHEA:55083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + D-fructose <=> ADP + H(+) + sucrose
RHEA:13909	skos:prefLabel	"urate-ribonucleoside phosphorylase"
RHEA:13909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"urate-ribonucleoside phosphorylase"
RHEA:13909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + urate D-ribonucleoside = alpha-D-ribose 1-phosphate + urate
REACT:R-CEL-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Caenorhabditis elegans)
REACT:R-DME-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Drosophila melanogaster)
REACT:R-SPO-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Schizosaccharomyces pombe)
REACT:R-HSA-167153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
RHEA:20527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate => ATP + ethylamine + L-glutamate
REACT:R-SPO-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Schizosaccharomyces pombe)
REACT:R-BTA-9756180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)
REACT:R-CFA-193385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of choloyl-CoA to cholate and CoASH (Canis familiaris)
REACT:R-SSC-1482689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)
REACT:R-DRE-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Danio rerio)
REACT:R-XTR-195251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the destruction complex (Xenopus tropicalis)
REACT:R-HSA-3266566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Homo sapiens)
RHEA:54934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-hexadecadienoyl-[ACP] + H2O => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP]
REACT:R-DDI-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Dictyostelium discoideum)
REACT:R-HSA-901006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Malectin (Homo sapiens)
GO:0060590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase regulator activity
GO:0060590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis regulator activity
REACT:R-SSC-416320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR1-containing  AMPA receptors (Sus scrofa)
REACT:R-CFA-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Canis familiaris)
REACT:R-HSA-380240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)
REACT:R-DME-5654408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS2 (Drosophila melanogaster)
REACT:R-DDI-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Dictyostelium discoideum)
REACT:R-MMU-5686900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 recruits DCLRE1C to ATM (Mus musculus)
RHEA:44723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycerol + H(+) + phosphocholine
REACT:R-DRE-1112604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STATs are released (Danio rerio)
REACT:R-HSA-8868659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
REACT:R-GGA-192475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Gallus gallus)
REACT:R-MMU-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Mus musculus)
REACT:R-SSC-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Sus scrofa)
RHEA:36899	skos:altLabel	"tRNA (m(1)G(37)) methyltransferase"
RHEA:36899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine
RHEA:36899	skos:altLabel	"transfer RNA (m(1)G(37)) methyltransferase"
RHEA:36899	skos:prefLabel	"tRNA (guanine(37)-N(1))-methyltransferase"
RHEA:36899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (guanine(37)-N(1))-methyltransferase"
RHEA:36899	skos:altLabel	"tRNA-(N(1)G37) methyltransferase"
RHEA:20254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,3-dimethylmalate => dimethylmaleate + H2O
RHEA:22989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + CoA + NADP(+) => acetyl-CoA + CO2 + NADPH
GO:0022886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	channel-forming ionophore activity
GO:0022886	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ionophore activity
REACT:R-SSC-5676598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:cIAP1/2 complex binds FN14:TWEAK (Sus scrofa)
REACT:R-HSA-174494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of ENV polyprotein (Homo sapiens)
RHEA:46008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + pentanal = H(+) + NADH + pentanoyl-CoA
REACT:R-SSC-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Sus scrofa)
RHEA:51171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-adrenaline + H2O + O2 <=> (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine
REACT:R-BTA-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate N-acetyltransferase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglutamic synthetase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate acetyltransferase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetylornithinase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglutamic-acetylornithine transacetylase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylornithine glutamate acetyltransferase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine transacetylase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglutamate-acetylornithine transacetylase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N-acetylglutamate synthase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N-acetyl-L-glutamate synthetase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine acetyltransferase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N-acetylglutamate synthetase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
GO:0004358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglutamate synthetase activity
REACT:R-HSA-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Homo sapiens)
REACT:R-MMU-445069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-EGFR trans-heterodimerization (Mus musculus)
RHEA:28882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-tryptophan(in) <=> H(+)(out) + L-tryptophan(out)
RHEA:68039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cystathionine ketimine + 2 H(+) + NADPH <=> (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)
REACT:R-XTR-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Xenopus tropicalis)
REACT:R-CEL-418176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB2 binds MAPKs, SRC-1 (Caenorhabditis elegans)
REACT:R-HSA-9708889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 6 binds NUP98:RAE1 within NPC (Homo sapiens)
REACT:R-RNO-6786155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLN binds ICL-DNA (Rattus norvegicus)
GO:0036455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-S transferase activity
GO:0036455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulfur transferase activity
GO:0036455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins (Homo sapiens)
RHEA:56384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
RHEA:11783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-DRE-5696213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to methylarsonite (Danio rerio)
REACT:R-MMU-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Mus musculus)
REACT:R-XTR-398193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC beta-mediated PIP2 hydrolysis (Xenopus tropicalis)
RHEA:40828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
REACT:R-BTA-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Bos taurus)
REACT:R-MMU-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Mus musculus)
RHEA:48290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GD3 + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM3
GO:0016872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular lyase activity
RHEA:50683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-terminal L-glutaminyl-[protein] <=> N-terminal L-glutamyl-[protein] + NH4(+)
REACT:R-XTR-2022065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPGs are secreted (Xenopus tropicalis)
REACT:R-DRE-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Danio rerio)
REACT:R-MMU-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Mus musculus)
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-vinylglycine deaminase activity
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-VG deaminase activity
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminocyclopropanecarboxylate synthase activity
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-aminocyclopropane-1-carboxylic acid synthase activity
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminocyclopropanecarboxylic acid synthase activity
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-aminocyclopropane-1-carboxylate synthetase activity
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-aminocyclopropanecarboxylate synthase activity
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine methylthioadenosine-lyase activity
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate synthase activity
GO:0016847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACC synthase activity
REACT:R-MMU-9691566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 binds nicorandil (Mus musculus)
REACT:R-CFA-453200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Canis familiaris)
REACT:R-MMU-1364044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR:JAK2 dimerizes (Mus musculus)
REACT:R-GGA-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Gallus gallus)
REACT:R-BTA-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Bos taurus)
REACT:R-CFA-912685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBP43 binds IFNAR2 and prevents JAK1 interaction (Canis familiaris)
RHEA:68920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + pentanoate = AMP + diphosphate + NADP(+) + pentanal
REACT:R-CFA-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Canis familiaris)
REACT:R-DME-2872497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-2 transports cytosolic urate to extracellular region (Drosophila melanogaster)
GO:0061656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
GO:0061656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO conjugating enzyme activity
RHEA:47667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) <=> 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-SSC-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Sus scrofa)
RHEA:17940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> methylglyoxal + phosphate
REACT:R-DRE-8950537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Danio rerio)
REACT:R-GGA-201648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, Endofin, recruits R-Smad1/5/8 (Gallus gallus)
REACT:R-DDI-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Dictyostelium discoideum)
REACT:R-CEL-749454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gi complex dissociates (Caenorhabditis elegans)
REACT:R-MMU-72143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lariat Formation and 5'-Splice Site Cleavage (Mus musculus)
REACT:R-CFA-9021596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane estrogen receptors bind SRC (Canis familiaris)
RHEA:22274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CEL-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Caenorhabditis elegans)
REACT:R-SSC-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Sus scrofa)
REACT:R-MMU-2467809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
REACT:R-GGA-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Gallus gallus)
RHEA:10301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + NAD(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH
RHEA:26241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"elisabethatriene synthase"
RHEA:26241	skos:prefLabel	"elisabethatriene synthase"
RHEA:26241	skos:altLabel	"elisabethatriene cyclase"
RHEA:26241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate = diphosphate + elisabethatriene
REACT:R-HSA-202137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 binds eNOS complex via HSP90 (Homo sapiens)
REACT:R-BTA-391151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47:SKAP2 binds FYB (Bos taurus)
REACT:R-HSA-1226016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
RHEA:51268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"norbelladine O-methyltransferase"
RHEA:51268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norbelladine + S-adenosyl-L-methionine = 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine
RHEA:51268	skos:prefLabel	"norbelladine O-methyltransferase"
REACT:R-HSA-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Homo sapiens)
REACT:R-MMU-8850997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 binds PTEN (Mus musculus)
RHEA:69710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O <=> beta-D-galactose + N-hexadecanoylsphinganine
REACT:R-MMU-5662613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 exchanges zinc for copper (Mus musculus)
REACT:R-BTA-9021596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane estrogen receptors bind SRC (Bos taurus)
RHEA:42933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:33518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5,6-dihydroxyindole + O2 <=> 2 H2O + 2 indole-5,6-quinone
REACT:R-HSA-508369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Homo sapiens)
RHEA:71452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bradykinin + H2O => bradykinin(1-7) + L-Phe-L-Arg
REACT:R-CEL-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Caenorhabditis elegans)
RHEA:70787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-citrulline(in) + L-ornithine(out) = H(+)(out) + L-citrulline(out) + L-ornithine(in)
REACT:R-BTA-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)
REACT:R-BTA-1250353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Bos taurus)
REACT:R-GGA-111237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR1 homodimer (Gallus gallus)
RHEA:31074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonate semialdehyde + L-alanine <=> (S)-3-amino-2-methylpropanoate + pyruvate
REACT:R-MMU-8857577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 facilitates PTK6 autophosphorylation (Mus musculus)
RHEA:67874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose
REACT:R-BTA-9014433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GEFs activate RHOG (Bos taurus)
REACT:R-SCE-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Saccharomyces cerevisiae)
RHEA:24483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O <=> a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol
REACT:R-DME-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Drosophila melanogaster)
RHEA:62848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-GGA-9625813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P binds S1PR3 in response to E2 stimulation (Gallus gallus)
REACT:R-MMU-176298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of claspin (Mus musculus)
REACT:R-MMU-3371518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 binds to HSF1 (Mus musculus)
GO:0047265	skos:altLabel	"UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase"
GO:0047265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"poly(glycerol-phosphate) alpha-glucosyltransferase"
GO:0047265	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity
GO:0047265	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity
GO:0047265	skos:prefLabel	"poly(glycerol-phosphate) alpha-glucosyltransferase"
GO:0047265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(glycerol-phosphate) alpha-glucosyltransferase activity
GO:0047265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP
GO:0047265	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity
GO:0047265	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity
REACT:R-DRE-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)
REACT:R-MMU-8931648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Mus musculus)
REACT:R-RNO-5218809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Rattus norvegicus)
REACT:R-XTR-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Xenopus tropicalis)
REACT:R-RNO-9676160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds NOD2 (Rattus norvegicus)
REACT:R-CEL-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Caenorhabditis elegans)
REACT:R-DME-350444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROK phosphorylates SQH (Drosophila melanogaster)
REACT:R-XTR-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Xenopus tropicalis)
RHEA:24895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyxanthotoxin + S-adenosyl-L-methionine => isopimpinellin + S-adenosyl-L-homocysteine
RHEA:65679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine <=> a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine
RHEA:69170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N-(2-carboxyethyl)spermidine + NADH => H2O + NAD(+) + spermine monoaldehyde
REACT:R-SCE-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Saccharomyces cerevisiae)
RHEA:62675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:53361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(47) in tRNA + NADP(+) => H(+) + NADPH + uridine(47) in tRNA
REACT:R-HSA-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Homo sapiens)
REACT:R-CEL-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)
RHEA:36277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theophylline
RHEA:24806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate
REACT:R-CFA-109823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Canis familiaris)
RHEA:53681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
REACT:R-HSA-6799431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds HIPK1 (Homo sapiens)
REACT:R-MMU-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Mus musculus)
RHEA:63981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-thiouridine + ATP => 4-thiouridine 5'-phosphate + ADP + H(+)
RHEA:31951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:31951	skos:altLabel	"CYP99A3"
RHEA:31951	skos:prefLabel	"9beta-pimara-7,15-diene oxidase"
RHEA:31951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"9beta-pimara-7,15-diene oxidase"
RHEA:31951	skos:altLabel	"9beta-pimara-7,15-diene monooxygenase"
REACT:R-BTA-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Bos taurus)
RHEA:33560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphate => a 2-acyl-sn-glycerol 3-phosphate + CoA
REACT:R-HSA-5685345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of isoAsp (Homo sapiens)
RHEA:61046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-2730847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP2 by PLCG (Mus musculus)
REACT:R-CFA-388560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA,EDNRB bind EDNs (Canis familiaris)
RHEA:71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + tartrate(in) => citrate(in) + tartrate(out)
REACT:R-HSA-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Homo sapiens)
REACT:R-DRE-1067688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Danio rerio)
RHEA:23612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-alpha-santonin + NAD(+) = alpha-santonin + H(+) + NADH
RHEA:21995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysyl-[histone] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]
RHEA:66884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-8854209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A binds JFC1 (Sus scrofa)
RHEA:31132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide
REACT:R-SCE-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Saccharomyces cerevisiae)
RHEA:68753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] => alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]
REACT:R-DRE-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Danio rerio)
GO:0017108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-flap endonuclease activity
GO:0017108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' flap endonuclease activity
REACT:R-GGA-8944220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIII (Gallus gallus)
REACT:R-DRE-5339535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTPD1 transports C1P from plasma membrane to Golgi membrane (Danio rerio)
RHEA:22583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxy-2-oxopentanoate <=> (2Z)-2-hydroxypenta-2,4-dienoate + H2O
RHEA:22858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-O-acetylsalutaridinol + CoA => (7S)-salutaridinol + acetyl-CoA
RHEA:49477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-1-piperideine-6-carboxylate + NAD(+) => H(+) + L-2-aminoadipate + NADH
RHEA:15912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + taurine <=> aminoacetaldehyde + CO2 + H(+) + succinate + sulfite
RHEA:29676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol(in) => glycerol(out)
RHEA:55004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxylimonen-2-one + NADPH + O2 = 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)
REACT:R-DDI-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Dictyostelium discoideum)
REACT:R-BTA-5672980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF complex (Bos taurus)
REACT:R-XTR-211881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A13 (Xenopus tropicalis)
REACT:R-GGA-2984220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1:CCNB phosphorylates NEK9 (Gallus gallus)
GO:0031726	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR1 chemokine receptor ligand
GO:0031726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR1 chemokine receptor binding
GO:0031726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrophage inflammatory protein-1 alpha receptor binding
REACT:R-BTA-8987161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Bos taurus)
REACT:R-MMU-8937191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Mus musculus)
REACT:R-RNO-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Rattus norvegicus)
REACT:R-XTR-5683425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53BP1 at DNA DSBs (Xenopus tropicalis)
GO:0015367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Homo sapiens)
GO:0015367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate/malate carrier protein
GO:0015367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Homo sapiens)
GO:0015367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxoglutarate:malate antiporter activity
REACT:R-CFA-183067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Localization of CBL:GRB2 to the membrane (Canis familiaris)
RHEA:56366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carminomycin + 2 H2O + NADP(+) => 13-dihydrocarminomycin + H(+) + NADPH + O2
REACT:R-GGA-5684006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translocates NBN to the nucleus (Gallus gallus)
REACT:R-CEL-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Caenorhabditis elegans)
RHEA:43181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-9755937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces LAN to 24,25-dhLAN (Mus musculus)
RHEA:34289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 L-dopaquinone => 2 L-dopa + O2
REACT:R-BTA-6805399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAF1 phosphorylates TP53 (Bos taurus)
GO:0052650	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	all-trans-retinol dehydrogenase activity
GO:0052650	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinol:NADP+ oxidoreductase activity
GO:0052650	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinol dehydrogenase [NADP+] activity
GO:0052650	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinol dehydrogenase activity
GO:0052650	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP(H)-dependent retinol dehydrogenase/reductase activity
GO:0052650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP-retinol dehydrogenase activity
GO:0052650	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	all-trans retinal reductase activity
REACT:R-DME-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Drosophila melanogaster)
GO:0016838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-oxygen lyase activity, acting on phosphates
REACT:R-DRE-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Danio rerio)
REACT:R-GGA-374298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid receptors bind opioid peptides (Gallus gallus)
REACT:R-CEL-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Caenorhabditis elegans)
RHEA:41606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine
RHEA:16131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine
REACT:R-MMU-205234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of GAB2 to p-KIT (Mus musculus)
RHEA:63965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-4E,14Z-dienine-1-phosphate => (2E,12Z)-hexadecadienal + phosphoethanolamine
REACT:R-RNO-9750016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Rattus norvegicus)
RHEA:17714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine
RHEA:59017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) => CO2 + cycloeucalenone + NADH
REACT:R-DRE-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Danio rerio)
REACT:R-HSA-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Homo sapiens)
RHEA:43138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine => guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine
REACT:R-HSA-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Homo sapiens)
RHEA:15335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-carbamoyl-2-oxoglycine + NADPH => (S)-ureidoglycolate + NADP(+)
REACT:R-HSA-9759141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2 and MAFK bind NQO1 gene (Homo sapiens)
REACT:R-HSA-8862184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP48 cleaves polyubiquitin (Homo sapiens)
REACT:R-CEL-354165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
REACT:R-RNO-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Rattus norvegicus)
REACT:R-GGA-166753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C4 into C4a and C4b (Gallus gallus)
REACT:R-XTR-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Xenopus tropicalis)
RHEA:14710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(5)-steroid => a 3-oxo-Delta(4)-steroid
RHEA:71478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin <=> L-isoleucyl-L-leucine + neurotensin(1-11)
RHEA:29977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine(out) + H(+)(out) => 2'-deoxycytidine(in) + H(+)(in)
RHEA:71680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-lysyl-glycine(out) => H(+)(in) + L-lysyl-glycine(in)
REACT:R-MMU-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Mus musculus)
RHEA:54827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] <=> alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)
REACT:R-HSA-983707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates at the activated BCR (Homo sapiens)
RHEA:61168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP
RHEA:14066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inosose => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O
RHEA:49932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA
RHEA:71344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-histidine(out) + 2 Na(+)(out) => chloride(in) + L-histidine(in) + 2 Na(+)(in)
RHEA:33142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(out) + L-aspartate(in) <=> L-alanine(in) + L-aspartate(out)
REACT:R-BTA-378952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin is a heterodimer (Bos taurus)
REACT:R-BTA-9007447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 forms the PRC1L4 complex (Bos taurus)
RHEA:60398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O
REACT:R-HSA-1222485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TrxB reactivates TrxA (Homo sapiens)
RHEA:52626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate
REACT:R-GGA-2574840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA facilitates AURKA autophosphorylation (Gallus gallus)
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome c1
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	electron transporter, transferring electrons within cytochrome c oxidase complex activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome b562
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquinol-cytochrome-c reductase activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquinone-cytochrome c oxidoreductase activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquinol-cytochrome c oxidoreductase activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytochrome
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitochondrial electron transport complex III
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquinol-cytochrome c1 oxidoreductase activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquinol-cytochrome c-2 oxidoreductase activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquinone--cytochrome-c oxidoreductase activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome a
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	soluble cytochrome b562
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome b566
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquinone-cytochrome c reductase activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquinol-cytochrome c2 reductase activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome a3/copper complex
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	complex III (mitochondrial electron transport) activity
GO:0008121	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquinol:ferricytochrome-c oxidoreductase activity
RHEA:63902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)
REACT:R-HSA-8961671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the ORC1 gene promoter (Homo sapiens)
REACT:R-RNO-6785607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCM binds FAAP24 (Rattus norvegicus)
RHEA:55363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol <=> 9-cis-retinol
RHEA:36213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O
RHEA:55198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + heptadecanal => 2-hydroxyoctadecanoyl-CoA
RHEA:30840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-beta-L-talose => UDP-N-acetyl-beta-L-fucosamine
REACT:R-XTR-9015122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors bind Va:Xa (Xenopus tropicalis)
REACT:R-GGA-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Gallus gallus)
RHEA:25394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) <=> cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH
REACT:R-XTR-2395223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyridinoline cross-links (Xenopus tropicalis)
RHEA:63646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+) => GDP-beta-L-fucose + L-seryl-[protein]
REACT:R-CFA-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Canis familiaris)
GO:0008820	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	AdoCbi kinase/AdoCbi-phosphate guanylyltransferase
GO:0008820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcobinamide-phosphate guanylyltransferase activity
GO:0008820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:adenosylcobinamide-phosphate guanylyltransferase activity
GO:0008820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:cobinamide phosphate guanylyltransferase activity
GO:0008820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobU
GO:0008820	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase
GO:0008820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobinamide phosphate guanylyltransferase activity
REACT:R-HSA-9617848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1B gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
REACT:R-SSC-2730894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)
REACT:R-XTR-4084903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types VI, IX bind integrin alpha10beta1 (Xenopus tropicalis)
GO:0097027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-protein transferase activator activity
REACT:R-HSA-2327733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 binds Collagen types I-V, VII (Homo sapiens)
REACT:R-SSC-71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer reduces PYR to LACT (Sus scrofa)
REACT:R-MMU-8964284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in active Gq-BTK complex is activated (Mus musculus)
RHEA:16096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:11005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + salicylate => catechol + CO2 + H2O + NAD(+)
REACT:R-HSA-9024785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)
RHEA:21413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADH
REACT:R-MMU-211919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F8 19-hydroxylates PGH2 (Mus musculus)
REACT:R-RNO-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Rattus norvegicus)
REACT:R-HSA-109823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
REACT:R-CFA-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Canis familiaris)
REACT:R-HSA-418865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ABLIM to the plasma membrane (Homo sapiens)
REACT:R-HSA-73632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Homo sapiens)
RHEA:29710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-anhydro-N-acetyl-beta-muramate(in) <=> 1,6-anhydro-N-acetyl-beta-muramate(out)
REACT:R-MMU-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Mus musculus)
REACT:R-BTA-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Bos taurus)
REACT:R-GGA-5610726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The IFT-A complex recruits TULP3 (Gallus gallus)
REACT:R-XTR-8987120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IFNLR1 (Xenopus tropicalis)
RHEA:35726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:38699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-XTR-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Xenopus tropicalis)
REACT:R-XTR-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Xenopus tropicalis)
RHEA:57331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]
REACT:R-BTA-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Bos taurus)
REACT:R-CFA-2424480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
REACT:R-SSC-2029273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to p-6Y-SYK (Sus scrofa)
REACT:R-DME-174367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCL ligates L-Glu to L-Cys (Drosophila melanogaster)
REACT:R-HSA-9633044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR binds STRN (Homo sapiens)
RHEA:37263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-aspartate(out) = ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate
RHEA:12691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + mycothione + NADH => 2 mycothiol + NAD(+)
REACT:R-HSA-1225951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
REACT:R-MMU-5668520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26Sproteasome degrades K48polyUb-NIK (Mus musculus)
REACT:R-HSA-421833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
RHEA:59307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + firefly L-luciferin <=> adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)
REACT:R-BTA-5626982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF binds GNB2L1 (Bos taurus)
REACT:R-PFA-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
REACT:R-CFA-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Canis familiaris)
RHEA:23183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + O2 <=> a ketone + H2O2
GO:0034013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity
GO:0034013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aliphatic aldoxime hydro-lyase activity
GO:0034013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OxdA
GO:0034013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aliphatic aldoxime dehydratase activity
REACT:R-CFA-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Canis familiaris)
REACT:R-DME-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)
RHEA:72401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + estrone 3-sulfate(out) => 2-oxoglutarate(out) + estrone 3-sulfate(in)
REACT:R-BTA-3341296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX7,8 catalyze peroxidation of P4HB (PDI) (Bos taurus)
RHEA:22735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + H(+) <=> 4-methylphenol + CO2
GO:0047430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharide-diphosphodolichol pyrophosphatase activity
GO:0047430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligosaccharide-diphosphodolichol phosphodolichohydrolase activity
GO:0047430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharide-diphosphodolichol diphosphatase activity
REACT:R-CFA-751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gz complex dissociates (Canis familiaris)
REACT:R-HSA-4411365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF (Homo sapiens)
REACT:R-CEL-75083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Caenorhabditis elegans)
RHEA:31201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H2O => (3S)-hydroxyoctanoyl-CoA
REACT:R-MMU-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Mus musculus)
REACT:R-BTA-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Bos taurus)
RHEA:18305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate
RHEA:18305	skos:prefLabel	"N-acetylneuraminate 4-O-acetyltransferase"
RHEA:18305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylneuraminate 4-O-acetyltransferase"
REACT:R-MMU-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Mus musculus)
REACT:R-CFA-443986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor ACKR2 binds most inflammatory CC chemokines (Canis familiaris)
REACT:R-GGA-8876191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 GEFs exchange GTP for GDP on RAB9 (Gallus gallus)
GO:0000825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol-tetrakisphosphate 6-kinase activity
GO:0000825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol tetrakisphosphate 6-kinase activity
GO:0000825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,3,4,5-tetrakisphosphate 6-kinase activity
RHEA:66992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylpentanoate + ATP + CoA = 3-methylpentanoyl-CoA + AMP + diphosphate
GO:0102771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid very long chain fatty acid alpha-hydroxylase activity
REACT:R-MMU-8869607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NAR to yield NAMN (Mus musculus)
RHEA:48390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose
RHEA:11120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)
RHEA:11120	skos:altLabel	"cyanate hydrolase"
RHEA:11120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanase"
RHEA:11120	skos:altLabel	"cyanate hydratase"
RHEA:11120	skos:prefLabel	"cyanase"
RHEA:11120	skos:altLabel	"cyanate aminohydrolase"
RHEA:11120	skos:altLabel	"cyanate lyase"
RHEA:11120	skos:altLabel	"cyanate C-N-lyase"
REACT:R-MMU-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Mus musculus)
RHEA:26436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan => indole + L-serine
GO:0018689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthalene disulphonate 1,2-dioxygenase activity
GO:0018689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthalene disulfonate 1,2-dioxygenase activity
GO:0031779	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	melanocortin receptor ligand
GO:0031779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melanocortin receptor binding
RHEA:55881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aequorin]--coelenterazine + O2 => [aequorin]
REACT:R-SSC-69891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of CHEK2 by ATM (Sus scrofa)
RHEA:58582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + catharanthine + H(+) => dihydroprecondylocarpine acetate
RHEA:28130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baicalin + H2O = baicalein + D-glucuronate + H(+)
REACT:R-CFA-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Canis familiaris)
RHEA:48603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein-PII]-uridylyl-L-tyrosine + H2O <=> [protein-PII]-L-tyrosine + H(+) + UMP
REACT:R-HSA-6803892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds BAX (Homo sapiens)
REACT:R-BTA-5654571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS3 (Bos taurus)
REACT:R-SCE-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Saccharomyces cerevisiae)
REACT:R-CFA-216050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Canis familiaris)
REACT:R-HSA-3311014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 (Homo sapiens)
RHEA:22986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-carbamoyl-2-oxoglycine + phosphate => carbamoyl phosphate + oxamate
REACT:R-MMU-1168633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB translocates from the cytosol to the nucleus (Mus musculus)
REACT:R-DRE-216072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Danio rerio)
REACT:R-DRE-2395314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysino-5-ketonorleucine cross-links (Danio rerio)
RHEA:67747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O <=> 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate
RHEA:68959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + scopoletin <=> H(+) + S-adenosyl-L-homocysteine + scoparone
REACT:R-HSA-5654622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
REACT:R-HSA-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Homo sapiens)
REACT:R-SCE-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Saccharomyces cerevisiae)
GO:0008668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + ATP + H(+) = 2,3-dihydroxybenzoyl-5'-AMP + diphosphate
GO:0008668	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:2,3-dihydroxybenzoate adenylyltransferase activity
GO:0008668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2,3-dihydroxybenzoyl)adenylate synthase activity
GO:0008668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate-AMP ligase activity
REACT:R-RNO-6786096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Rattus norvegicus)
RHEA:43831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-HSA-139913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
REACT:R-RNO-444647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3a receptor binds anaphylatoxin C3a (Rattus norvegicus)
REACT:R-SSC-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Sus scrofa)
REACT:R-DRE-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
RHEA:52643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA
REACT:R-DME-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Drosophila melanogaster)
RHEA:70646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-proline(out) + H(+)(out) <=> D-proline(in) + H(+)(in)
REACT:R-CEL-6788855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3KRP phosphorylates PsiAm, RibAm (Caenorhabditis elegans)
REACT:R-CEL-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Caenorhabditis elegans)
REACT:R-SSC-2168886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemopexin binds Hemes (Sus scrofa)
REACT:R-CFA-2214330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of collagen VII NC2 region by BMP1 (Canis familiaris)
REACT:R-SSC-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Sus scrofa)
RHEA:22953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octanedioyl-CoA => (2E)-octenedioyl-CoA + H2O2
EC:3.4.13.-	skos:prefLabel	"Dipeptidases"
EC:3.4.13.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Dipeptidases"
REACT:R-DRE-976743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates plasma Factor H-bound C3b (Danio rerio)
RHEA:62499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-arginine <=> diphosphate + L-arginyl-AMP
REACT:R-SSC-6814671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of late-endosome derived vesicles at the TGN (Sus scrofa)
RHEA:59446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A
RHEA:30491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-400183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA:RXRA binds Corepressors of PPARA (Homo sapiens)
REACT:R-XTR-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Xenopus tropicalis)
REACT:R-HSA-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Homo sapiens)
REACT:R-BTA-983161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Bos taurus)
REACT:R-HSA-5675948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFRSF6B binds TNFSF6,14,15 (Homo sapiens)
REACT:R-DRE-6801762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A oligomerize to form a pore complex (Danio rerio)
REACT:R-RNO-209087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBA is phosphorylated by Phospho IKKB kinase (Rattus norvegicus)
RHEA:24151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Homo sapiens)
RHEA:57096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + S-methyl-1-thio-D-xylulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + methanethiol
REACT:R-RNO-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Rattus norvegicus)
REACT:R-HSA-1592243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of POLRMT (Homo sapiens)
REACT:R-BTA-2514772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Bos taurus)
RHEA:40477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate + dibutanoylglycerol + H(+) => 1,2,3-tributanoylglycerol + H2O
REACT:R-DRE-2022063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Danio rerio)
RHEA:28993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminate(out) => N-acetylneuraminate(in)
GO:0010279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAA amino acid synthetase activity
GO:0010279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAA amino acid conjugate synthetase activity
GO:0010279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetic acid amido synthetase activity
GO:0010279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAA amido synthetase activity
REACT:R-SSC-380316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of NuMA with microtubules (Sus scrofa)
REACT:R-SSC-112271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex dissociates (Sus scrofa)
REACT:R-MMU-8855381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dephosphorylates ZAP70 (Mus musculus)
REACT:R-BTA-5655466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Bos taurus)
RHEA:28856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + melibiose(in) => H(+)(out) + melibiose(out)
RHEA:49248	skos:altLabel	"galactitol PTS permease"
RHEA:49248	skos:prefLabel	"protein-N(pi)-phosphohistidine--galactitol phosphotransferase"
RHEA:49248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--galactitol phosphotransferase"
RHEA:49248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol(out) + N(pros)-phospho-L-histidyl-[protein] = galactitol 1-phosphate(in) + L-histidyl-[protein]
REACT:R-HSA-9647645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD oligomerizes into arc-, slit-shaped structures (Homo sapiens)
REACT:R-DME-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Drosophila melanogaster)
RHEA:52481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-74716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin binds the insulin receptor (Rattus norvegicus)
REACT:R-XTR-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Xenopus tropicalis)
REACT:R-HSA-5635841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins are phosphorylated (Homo sapiens)
REACT:R-DRE-450499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B (AKT) phosphorylates KSRP (Danio rerio)
REACT:R-XTR-176585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Xenopus tropicalis)
RHEA:68155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,3-diacylglycerol + a fatty acyl-CoA <=> a triacylglycerol + CoA
GO:0031782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 4 melanocortin receptor binding
GO:0031782	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 4 melanocortin receptor ligand
REACT:R-MMU-432237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Mus musculus)
REACT:R-BTA-1295609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
REACT:R-RNO-2993898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRK1/VRK2 phosphorylate BANF1 (Rattus norvegicus)
REACT:R-RNO-8848436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CDKN1B (Rattus norvegicus)
REACT:R-GGA-8853734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Gallus gallus)
RHEA:35693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-hydroxyversicolorone + H(+) + NADPH => (2S)-versicolorone + NADP(+)
RHEA:44551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-9701485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds JAK3 (Xenopus tropicalis)
RHEA:52063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)
REACT:R-BTA-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Bos taurus)
REACT:R-CFA-8939335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 polyubiquinates BCL10 (Canis familiaris)
RHEA:28062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
REACT:R-XTR-9668902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18-RFC(7s) complex (Xenopus tropicalis)
EC:2.7.3.-	skos:prefLabel	"Phosphotransferases with a nitrogenous group as acceptor"
EC:2.7.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphotransferases with a nitrogenous group as acceptor"
REACT:R-HSA-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Homo sapiens)
REACT:R-MMU-5682863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF168 binds DNA DSBs (Mus musculus)
REACT:R-DME-8950780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 binds p-Y693-STAT4 (Drosophila melanogaster)
RHEA:68548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + psoralen + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol
RHEA:33683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine + octadecanoyl-CoA = 3-oxoeicosasphinganine + CO2 + CoA
RHEA:56022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)
RHEA:61317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + phosphate => H2O + NADP(+)
RHEA:18941	skos:prefLabel	"A-factor type gamma-butyrolactone 1'-reductase (1S-forming)"
RHEA:18941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH
RHEA:18941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"A-factor type gamma-butyrolactone 1'-reductase (1S-forming)"
REACT:R-DRE-8853405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 binds AURKA at centrosomes (Danio rerio)
REACT:R-DME-879562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Drosophila melanogaster)
REACT:R-XTR-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Xenopus tropicalis)
GO:0000171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase MRP
GO:0000171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease MRP activity
RHEA:60335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-DME-2066781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Drosophila melanogaster)
REACT:R-RNO-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)
REACT:R-RNO-212269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Rattus norvegicus)
REACT:R-MMU-450499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B (AKT) phosphorylates KSRP (Mus musculus)
REACT:R-GGA-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Gallus gallus)
REACT:R-GGA-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
RHEA:29573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-idonate(out) => H(+)(in) + L-idonate(in)
RHEA:58531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)
REACT:R-GGA-351434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of H2AX at S139 by ATM at the site of DSB (Gallus gallus)
EC:3.4.24.70	skos:prefLabel	"oligopeptidase A"
EC:3.4.24.70	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligopeptidase A"
REACT:R-MMU-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Mus musculus)
REACT:R-HSA-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Homo sapiens)
REACT:R-CFA-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Canis familiaris)
RHEA:32021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cubebene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:24864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose <=> H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP
REACT:R-RNO-199917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates CREB at Serine 133 (Rattus norvegicus)
RHEA:69485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecan-1-ol + O2 => dodecanal + H2O2
RHEA:42690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ergothioneine + NH4(+) + pyruvate => AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide
REACT:R-HSA-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Homo sapiens)
RHEA:35510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Bos taurus)
RHEA:51339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate
REACT:R-SSC-390304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoASH (Sus scrofa)
REACT:R-DRE-446868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Interleukin 1 receptor complex binds Tollip (Danio rerio)
REACT:R-SSC-1250348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by ERBB4 homodimers (Sus scrofa)
RHEA:16438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + RX => a halide anion + an S-substituted glutathione + H(+)
RHEA:39620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)
REACT:R-SSC-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Sus scrofa)
RHEA:71120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hispidin + NADPH + O2 => 3-hydroxyhispidin + H2O + NADP(+)
EC:2.4.99.4	skos:prefLabel	"beta-galactoside alpha-2,3-sialyltransferase"
EC:2.4.99.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-galactoside alpha-2,3-sialyltransferase"
EC:2.4.99.4	skos:altLabel	"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase"
GO:0004567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannase activity
GO:0004567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-mannosidase activity
GO:0004567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannanase activity
GO:0004567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-mannoside mannohydrolase activity
GO:0004567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-mannosidase activity
GO:0004567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-D-mannanase activity
GO:0004567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-mannoside mannohydrolase activity
REACT:R-BTA-2534388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone Activation Of CatSper (Bos taurus)
REACT:R-DRE-2395340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxyallysine by LOX (Danio rerio)
REACT:R-HSA-6801195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3 binds BNIP3L (Homo sapiens)
REACT:R-HSA-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Homo sapiens)
REACT:R-RNO-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Rattus norvegicus)
REACT:R-GGA-194311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Gallus gallus)
RHEA:46543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:57386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA => (13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA
RHEA:56651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH
REACT:R-SSC-199576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR3DL2 interacting with HLA-A3 (Sus scrofa)
RHEA:48491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol--[retinol-binding protein] + NAD(+) <=> all-trans-retinal--[retinol-binding protein] + H(+) + NADH
REACT:R-BTA-2022412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)
GO:0062144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-propargylglycine synthase activity
GO:0062144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-amino-4-chloropent-4-enoate = chloride + H(+) + L-propargylglycine
RHEA:14994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)
REACT:R-HSA-8932033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD6 gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)
GO:0031721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hemoglobin alpha binding
RHEA:47631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + propanoyl-CoA <=> 3-methylmalate + CoA + H(+)
GO:0102202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soladodine glucosyltransferase activity
REACT:R-DME-203553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS binds NOSIP (Drosophila melanogaster)
REACT:R-CFA-5654634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates SHC1 (Canis familiaris)
REACT:R-CEL-372529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of acetylcholine at the synapse (Caenorhabditis elegans)
RHEA:51508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-proline + O2 = CO2 + succinate + trans-4-hydroxy-L-proline
RHEA:51508	skos:prefLabel	"L-proline trans-4-hydroxylase"
RHEA:51508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-proline trans-4-hydroxylase"
GO:0033293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monocarboxylic acid binding
REACT:R-MMU-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Mus musculus)
REACT:R-DRE-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)
RHEA:33851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) = GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine
REACT:R-CEL-193455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)
RHEA:70161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate(out) + H(+)(out) => folate(in) + H(+)(in)
GO:0031249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	denatured protein binding
RHEA:45111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0015421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent oligopeptide transmembrane transporter activity
GO:0015421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type oligopeptide transporter activity
GO:0015421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled oligopeptide transmembrane transporter activity
GO:0015421	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oligopeptide ABC transporter
GO:0015421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligopeptide permease activity
GO:0015421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligopeptide-transporting ATPase activity
GO:0015421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type oligopeptide transporter
REACT:R-BTA-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Bos taurus)
REACT:R-GGA-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Gallus gallus)
REACT:R-DME-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Drosophila melanogaster)
REACT:R-MMU-1237047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ hydrates CO2 to HCO3- (Mus musculus)
REACT:R-BTA-9726875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCNs:cAMP bind SNIs (Bos taurus)
REACT:R-MMU-2730862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of LYN kinase (Mus musculus)
REACT:R-DDI-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Dictyostelium discoideum)
REACT:R-CEL-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Caenorhabditis elegans)
REACT:R-XTR-9020277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Xenopus tropicalis)
RHEA:18220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an alkane-alpha,omega-diamine <=> an omega-aminoaldehyde + L-glutamate
RHEA:54666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-alpha-onocerin => (3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene
REACT:R-XTR-109278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Xenopus tropicalis)
REACT:R-BTA-202237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
REACT:R-RNO-112436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin complex (Rattus norvegicus)
RHEA:10730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-6-deoxy-alpha-D-talose + NAD(+)
EC:2.1.1.18	skos:prefLabel	"polysaccharide O-methyltransferase"
EC:2.1.1.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polysaccharide O-methyltransferase"
REACT:R-HSA-8877414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter (Homo sapiens)
REACT:R-HSA-2396113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dystroglycan binds AGRN and HSPG2 (Homo sapiens)
REACT:R-HSA-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Homo sapiens)
RHEA:60348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
RHEA:60348	skos:prefLabel	"[histone H4]-N-methyl-L-lysine(20) N-methyltransferase"
RHEA:60348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H4]-N-methyl-L-lysine(20) N-methyltransferase"
REACT:R-HSA-3828061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GYS1 does not transfer glucose to growing glycogen chains (Homo sapiens)
RHEA:28206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + ATP = ADP + dUMP + H(+)
REACT:R-SSC-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Sus scrofa)
RHEA:27748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + cysteamine => H(+) + L-cysteine
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GK
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerate-3-kinase activity
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerate kinase activity
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-glycerate 2-phosphotransferase activity
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:(R)-glycerate 3-phosphotransferase activity
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)
GO:0008887	skos:prefLabel	"glycerate 3-kinase"
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glycerate kinase activity
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glycerate 3-kinase activity
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerate 3-kinase"
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerate kinase (phosphorylating)
GO:0008887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glyceric acid kinase activity
RHEA:68811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-alpha-D-glucopyranosyl-D-fructose + H2O <=> alpha-D-glucose + D-fructose
RHEA:52472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:47772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:68649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-cysteine => H(+) + hydrogen sulfide + L-lanthionine
REACT:R-DME-8937177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD binds ARNT (Drosophila melanogaster)
REACT:R-BTA-933531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-IRF7:p-IRF7 to nucleus (Bos taurus)
REACT:R-SSC-5654679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR3 (Sus scrofa)
REACT:R-RNO-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Rattus norvegicus)
REACT:R-DDI-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Dictyostelium discoideum)
REACT:R-XTR-877187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates loss of intracellular K+ (Xenopus tropicalis)
RHEA:59284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = D-glucose + N-octadecanoylsphing-4-enine
REACT:R-DRE-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Danio rerio)
RHEA:61630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-piperideine + H2O => 5-aminopentanal
RHEA:59248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA = (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA
GO:0070539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleic acid binding
REACT:R-DRE-70355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALK1 phosphorylates Gal to Gal1P (Danio rerio)
RHEA:16490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-prunasin + H2O => D-glucose + mandelonitrile
RHEA:14410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteamine + O2 => H(+) + hypotaurine
GO:0018783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deisopropyldeethylatrazine hydrolase activity
RHEA:63168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + L-cysteine = S-(2-succino)-L-cysteine
REACT:R-RNO-174374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 from MeCbl to HCYS (Rattus norvegicus)
RHEA:70149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:24909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine <=> (E)-4-coumarate + NH4(+)
REACT:R-XTR-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)
RHEA:55749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SCE-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Saccharomyces cerevisiae)
REACT:R-SCE-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Saccharomyces cerevisiae)
REACT:R-XTR-975593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Xenopus tropicalis)
RHEA:64884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP = (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)
RHEA:35275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoyl-CoA + NAD(+) = 3-oxooctadecanoyl-CoA + H(+) + NADH
REACT:R-SCE-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Saccharomyces cerevisiae)
RHEA:23942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate + H(+) + NADH => D-gluconate + NAD(+)
REACT:R-SSC-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Sus scrofa)
REACT:R-DDI-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Dictyostelium discoideum)
RHEA:29803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-valine(out) = ADP + H(+) + L-valine(in) + phosphate
REACT:R-CEL-209903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline is converted to adrenaline (Caenorhabditis elegans)
REACT:R-BTA-5682965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Bos taurus)
RHEA:35111	skos:altLabel	"2,5-diketo-D-gluconate-reductase"
RHEA:35111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH
RHEA:35111	skos:prefLabel	"2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)"
RHEA:35111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)"
REACT:R-RNO-4551727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Rattus norvegicus)
REACT:R-CEL-5617815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binds RAB3IP (Caenorhabditis elegans)
GO:0033746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity (H3-R2 specific)
GO:0033746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R2 demethylase activity
GO:0033746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-methyl-arginine-2 demethylase activity
GO:0033746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-R2 demethylase activity
GO:0033746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R2me demethylase activity
REACT:R-DRE-4641249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Danio rerio)
REACT:R-SPO-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Schizosaccharomyces pombe)
REACT:R-XTR-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Xenopus tropicalis)
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopachrome rearranging enzyme activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopachrome Delta(7),Delta(2)-isomerase activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryosinase-related protein-2
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopachrome keto-enol isomerase activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopachrome oxidoreductase activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TRP-1
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dopachrome conversion factor activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopachrome delta7,Delta2-isomerase activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopachrome delta-isomerase activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopachrome-rearranging enzyme
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-dopachrome keto-enol isomerase activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosinase-related protein 2 activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-dopachrome isomerase activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopachrome isomerase activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TRP2
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TRP-2
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TRP activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DCT activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dopachrome conversion activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-dopachrome-methyl ester tautomerase activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DCF activity
GO:0004167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopachrome tautomerase activity
GO:0030413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	competence pheromone activity
REACT:R-BTA-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Bos taurus)
REACT:R-HSA-975874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)
RHEA:51043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate imine dimer <=> chromopyrrolate + H(+) + NH4(+)
REACT:R-XTR-5661120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Xenopus tropicalis)
REACT:R-HSA-9700184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of point mutants of ALK (Homo sapiens)
REACT:R-DME-8853745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA3 (Drosophila melanogaster)
RHEA:65791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Homo sapiens)
RHEA:44805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) => 2-demethylmenaquinol-9 + CO2 + diphosphate
REACT:R-MMU-2060328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS1 (Mus musculus)
REACT:R-HSA-1299476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPP cleaves targeting peptide (presequence) of inner membrane precursors (Homo sapiens)
RHEA:31235	skos:prefLabel	"4-hydroxyglutamate transaminase"
RHEA:31235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyglutamate transaminase"
RHEA:31235	skos:altLabel	"4-hydroxyglutamate aminotransferase"
RHEA:31235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate
RHEA:31286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + FADH2
GO:0016888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0016888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endodeoxyribonuclease activity, producing 5' phosphomonoesters
RHEA:55733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)
REACT:R-CEL-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Caenorhabditis elegans)
RHEA:21833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-183084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)
REACT:R-BTA-400143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fatty acid ligands activate PPARA (Bos taurus)
REACT:R-BTA-9627107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP7 (Bos taurus)
REACT:R-RNO-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Rattus norvegicus)
RHEA:12708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-L-isoaspartate + S-adenosyl-L-methionine <=> [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine
REACT:R-BTA-5686398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPIDR binds BLM:TOP3A:RMI1:RMI2 (Bos taurus)
GO:0050541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta,beta-carotene-9',10'-dioxygenase activity
GO:0050541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	b,b-carotene-9',10'-dioxygenase activity
REACT:R-CFA-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Canis familiaris)
RHEA:53622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-spiroviolene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-SSC-170844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 is cleaved by FURIN (Sus scrofa)
RHEA:36769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine => 2-hydroxytetracosenoyl-CoA + sphinganine
RHEA:20807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA
RHEA:34958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(methylsulfanyl)-D-ribose(in) <=> 5-(methylsulfanyl)-D-ribose(out)
REACT:R-MMU-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Mus musculus)
REACT:R-SSC-379048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)
REACT:R-HSA-9650722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translation of DDIT3 (Homo sapiens)
RHEA:39024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-450827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Caenorhabditis elegans)
REACT:R-DME-9009817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acitretin binds to RAR:RXR (Drosophila melanogaster)
GO:0050232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine oxidase activity
GO:0050232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine:oxygen oxidoreductase (deaminating)
REACT:R-BTA-9645394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Bos taurus)
RHEA:23519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + ATP <=> (2R)-3-phosphoglycerate + ADP + H(+)
RHEA:32721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:20216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] <=> L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]
REACT:R-HSA-8936214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCY2C trimer binds GUCA2A,B (Homo sapiens)
GO:0003834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-carotene 15,15'-monooxygenase activity
GO:0003834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carotene dioxygenase activity
GO:0003834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-carotene 15,15'-dioxygenase activity
GO:0003834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carotene 15,15'-dioxygenase activity
REACT:R-MMU-171087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR [endosome membrane] => LDLR [plasma membrane] (Mus musculus)
REACT:R-DRE-71260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Danio rerio)
EC:1.1.1.382	skos:prefLabel	"ketol-acid reductoisomerase (NAD(+))"
EC:1.1.1.382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ketol-acid reductoisomerase (NAD(+))"
RHEA:66961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
REACT:R-HSA-8956659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates YAP1 (Homo sapiens)
REACT:R-GGA-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Gallus gallus)
REACT:R-XTR-182988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty lures CBL away from EGFR (Xenopus tropicalis)
REACT:R-BTA-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Bos taurus)
REACT:R-CEL-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Caenorhabditis elegans)
RHEA:32974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine
REACT:R-RNO-2484965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII binds Integrin alpha1beta1 (Rattus norvegicus)
GO:0086084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication
RHEA:70506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopentenyl diphosphate <=> H(+) + isopentenyl phosphate + phosphate
REACT:R-HSA-981728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to membrane-associated C3b (Homo sapiens)
REACT:R-SSC-159783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)
REACT:R-CFA-9020278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Canis familiaris)
GO:0015647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan transmembrane transporter activity
GO:0015647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	murein transporter activity
REACT:R-BTA-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Bos taurus)
REACT:R-RNO-8938867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND3,(CCND1,CCND2) binds RUNX1 (Rattus norvegicus)
REACT:R-XTR-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Xenopus tropicalis)
REACT:R-SSC-5218822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK binds BCAR1 and or PXN (Sus scrofa)
RHEA:23956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
RHEA:30392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-glutamine => 2-oxoglutaramate + L-methionine
RHEA:14730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
GO:0140347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-retinylidene-phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)
GO:0140347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-retinylidene-phosphatidylethanolamine flippase activity
REACT:R-HSA-9634916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 gene expression is stimulated by NPAS4 (Homo sapiens)
RHEA:66514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:45471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate <=> (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate
RHEA:50777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanal + NADP(+) => (E)-hex-2-enal + H(+) + NADPH
REACT:R-BTA-165026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Bos taurus)
RHEA:29634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraose + H2O <=> alpha-D-glucose + D-maltotriose
RHEA:71649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain (2E)-enoyl-CoA + H2O => a medium-chain (3S)-3-hydroxyacyl-CoA
REACT:R-GGA-4341070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PPARA with SUMO1 (Gallus gallus)
RHEA:41447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 <=> glycine + 2 H(+) + phosphate
RHEA:56230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine
RHEA:63155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-fatty acyl-taurine + H2O <=> a fatty acid + taurine
REACT:R-HSA-1989756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ME1 (Homo sapiens)
RHEA:16140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + NADP(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADPH
REACT:R-RNO-8848215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Rattus norvegicus)
REACT:R-GGA-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Gallus gallus)
REACT:R-RNO-9728150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 binds gliflozins (Rattus norvegicus)
RHEA:41114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate
REACT:R-HSA-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Homo sapiens)
RHEA:24519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + gentamicin C1a <=> CoA + H(+) + N(2')-acetylgentamicin C1a
RHEA:66229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-C13-CoA + O2 => asc-DeltaC13-CoA + H2O2
REACT:R-BTA-2022061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan sulfate can be further sulfated on position 2 of iduronate (Bos taurus)
REACT:R-BTA-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Bos taurus)
REACT:R-CFA-9679028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 binds JAK3 inhibitors (Canis familiaris)
REACT:R-GGA-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Gallus gallus)
REACT:R-BTA-1482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by HADH (IM) (Bos taurus)
RHEA:23469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzenesulfonate + 2 H(+) + NADH + O2 => 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)
REACT:R-CFA-904830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
RHEA:43667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + tetracosanoyl-CoA <=> 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate
REACT:R-MMU-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
REACT:R-SSC-176116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of Chk1 (Sus scrofa)
REACT:R-MMU-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Mus musculus)
REACT:R-XTR-166721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Xenopus tropicalis)
REACT:R-RNO-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Rattus norvegicus)
GO:0050235	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal:NAD+ 4-oxidoreductase activity
GO:0050235	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal dehydrogenase activity
GO:0050235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal 4-dehydrogenase activity
REACT:R-CFA-193491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Canis familiaris)
REACT:R-PFA-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Plasmodium falciparum)
RHEA:11845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + formate => CoA + pyruvate
RHEA:47362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic alcohol + decanoate + H(+) => decanoate ester + H2O
REACT:R-SSC-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)
REACT:R-SSC-429016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 is phosphorylated by MAPKAP2 (Sus scrofa)
RHEA:12750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate + H(+) => 1,2,3-trihydroxybenzene + CO2
REACT:R-DME-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Drosophila melanogaster)
GO:0047685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amine sulfotransferase"
GO:0047685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amine sulphotransferase activity
GO:0047685	skos:altLabel	"amine N-sulfotransferase"
GO:0047685	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amine N-sulfotransferase activity
GO:0047685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a primary amine = a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)
GO:0047685	skos:prefLabel	"amine sulfotransferase"
GO:0047685	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity
GO:0047685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylamine sulfotransferase activity
GO:0047685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amine sulfotransferase activity
GO:0047685	skos:altLabel	"arylamine sulfotransferase"
REACT:R-MMU-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Mus musculus)
REACT:R-RNO-2426471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Rattus norvegicus)
RHEA:53987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
RHEA:11553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + acetate + H(+)
RHEA:12644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + NAD(+) <=> 3-phosphooxypyruvate + H(+) + NADH
GO:0034481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin sulfotransferase activity
RHEA:64245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + glycine => an N-(fatty acyl)-glycine + CoA + H(+)
RHEA:62860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 H(+) + 7 malonyl-CoA = 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O
REACT:R-HSA-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
REACT:R-RNO-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Rattus norvegicus)
REACT:R-BTA-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
RHEA:64259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + glycine <=> CoA + H(+) + N-dodecanoylglycine
RHEA:38694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)
RHEA:53027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + H2O + L-arginine <=> 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)
REACT:R-RNO-5696914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP28 deubiquitinates CLSPN and MYC (Rattus norvegicus)
RHEA:25345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + urea <=> carbamate + NH4(+)
REACT:R-MMU-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Mus musculus)
REACT:R-DME-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Drosophila melanogaster)
RHEA:56792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-HSA-9023538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds PTPN1 gene promoter (Homo sapiens)
RHEA:58246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + L-lysyl-[protein] => H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein]
RHEA:36571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + tetradecanoyl-CoA = CoA + H(+) + N-(tetradecanoyl)-sphinganine
RHEA:67169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-hydroxy-L-phenylalanine => 3-(3-hydroxyphenyl)pyruvate + L-glutamate
RHEA:34770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + H2O <=> (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)
RHEA:57175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH
RHEA:64745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-3-(hexan-1-ol)-L-cysteine => 3-sulfanyl-1-hexanol + NH4(+) + pyruvate
REACT:R-SPO-5692764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 binds CCND3 (Schizosaccharomyces pombe)
REACT:R-CFA-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Canis familiaris)
RHEA:42762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + 2 H(+) + NADH => D-glyceraldehyde 3-phosphate + H2O + NAD(+)
REACT:R-RNO-174122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Rattus norvegicus)
REACT:R-DRE-6804527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INTL1 binds bacterial glycans (Danio rerio)
RHEA:39744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)
REACT:R-DRE-976810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to extracellular Factor H:C3b (Danio rerio)
RHEA:71918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauronorcholate(out) <=> 2 Na(+)(in) + tauronorcholate(in)
RHEA:46905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)
GO:0047293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity
GO:0047293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoic-polyprenyl transferase activity
GO:0047293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoate dimethylallyltransferase activity
GO:0047293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate transferase activity
GO:0047293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate nonaprenyltransferase activity
GO:0047293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate
GO:0047293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nonaprenyl-4-hydroxybenzoate transferase activity
GO:0047293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoic acid-polyprenyl transferase activity
GO:0047293	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoate polyprenyltransferase activity
REACT:R-HSA-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Homo sapiens)
RHEA:61993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
REACT:R-SCE-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Saccharomyces cerevisiae)
REACT:R-BTA-6805059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2:FACT phosphorylates TP53 (Bos taurus)
REACT:R-CFA-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Canis familiaris)
RHEA:72917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructopyranose(in) + Na(+)(in) => D-fructopyranose(out) + Na(+)(out)
RHEA:44101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + octanal => 2 H(+) + NADH + octanoate
RHEA:45666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)
REACT:R-GGA-8853762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET dimerizes (Gallus gallus)
RHEA:34395	skos:prefLabel	"phenylalanine aminomutase (L-beta-phenylalanine forming)"
RHEA:34395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine = L-beta-phenylalanine
RHEA:34395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine aminomutase (L-beta-phenylalanine forming)"
REACT:R-HSA-6800198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Homo sapiens)
REACT:R-BTA-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Bos taurus)
REACT:R-RNO-349657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)
REACT:R-DRE-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Danio rerio)
REACT:R-CEL-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Caenorhabditis elegans)
REACT:R-CFA-448678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTSG cleaves CASP1(1-404) (Canis familiaris)
REACT:R-SSC-6798258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTPRF, PTPRS, PTPRD bind LRRC4B (Sus scrofa)
REACT:R-DDI-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Dictyostelium discoideum)
REACT:R-RNO-5696220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to arsenite(3-) (Rattus norvegicus)
REACT:R-RNO-6811414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF (Rattus norvegicus)
RHEA:70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetyl-CoA + H2O => 3,4-dihydroxyphenylacetate + CoA + H(+)
REACT:R-BTA-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Bos taurus)
REACT:R-CFA-1022129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Canis familiaris)
GO:0004368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycerol-3-phosphate dehydrogenase activity
GO:0004368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD-dependent glycerol-3-phosphate dehydrogenase
GO:0004368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate dehydrogenase (quinone) activity
GO:0004368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphate dehydrogenase activity
GO:0004368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin-linked glycerol-3-phosphate dehydrogenase
GO:0004368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glycerophosphate dehydrogenase activity
GO:0004368	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol-3-phosphate CoQ reductase
GO:0004368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol-3-phosphate:quinone oxidoreductase activity
RHEA:54068	skos:prefLabel	"sesterfisherol synthase"
RHEA:54068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sesterfisherol synthase"
RHEA:54068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + sesterfisherol
RHEA:56184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + UDP-alpha-D-galactose = globoside NOR1 + H(+) + UDP
RHEA:58608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-decanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine
REACT:R-HSA-5251555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of AXIN1 gene (Homo sapiens)
REACT:R-HSA-8949399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAR translocates from the cytosol to the mitochondrial intermembrane space (Homo sapiens)
REACT:R-CFA-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Canis familiaris)
RHEA:55954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose
RHEA:60925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + L-lysyl-[protein] + succinate
GO:0050400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:xylitol 5-phosphotransferase activity
GO:0050400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylitol kinase activity
GO:0050400	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylitol phosphotransferase activity
RHEA:43198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine => adenosine(4) in tRNA(His) + S-adenosyl-L-methionine
REACT:R-DRE-9750946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2,6 ubiquitinates NLRC5 (Danio rerio)
RHEA:64796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)
GO:0089721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate transmembrane transporter activity
RHEA:43340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]
REACT:R-MMU-936942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)
RHEA:47370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose
RHEA:59585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-lysine => ADP + beta-alanyl-L-lysine + H(+) + phosphate
REACT:R-RNO-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
REACT:R-DME-375768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Drosophila melanogaster)
REACT:R-DDI-69608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk2 (Dictyostelium discoideum)
RHEA:64953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCDP + H2O => dCMP + H(+) + phosphate
GO:0004120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	photoreceptor cyclic-nucleotide phosphodiesterase activity
REACT:R-HSA-437932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y348-SYK binds VAV family (Homo sapiens)
REACT:R-SCE-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Saccharomyces cerevisiae)
RHEA:68895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxybenzoate + ATP + H(+) + NADPH <=> 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)
RHEA:20765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + pyruvate => oxaloacetate + propanoyl-CoA
REACT:R-RNO-9645520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)
REACT:R-DRE-74101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerization of 11c-retinyl to at-retinyl (Danio rerio)
REACT:R-HSA-5654734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)
REACT:R-BTA-9023627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Bos taurus)
REACT:R-RNO-163099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alignment Of The RNA Template On The Telomeric Chromosome End (Rattus norvegicus)
REACT:R-RNO-73598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Rattus norvegicus)
GO:0034324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-hexanoyltransferase activity
REACT:R-CFA-5340251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Canis familiaris)
GO:0016985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-mannanase B
GO:0016985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-mannan 4-mannanohydrolase activity
GO:0016985	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-mannanase activity
GO:0016985	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-beta-mannanase activity
GO:0016985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannan endo-1,4-beta-mannosidase activity
GO:0016985	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-1,4-mannanase activity
GO:0016985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,4-beta-mannanase activity
GO:0016985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-mannanase activity
GO:0016985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-1,4-mannase activity
GO:0016985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-D-mannan mannanohydrolase activity
REACT:R-MMU-9617067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Mus musculus)
REACT:R-MMU-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Mus musculus)
RHEA:32859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-HSA-9615570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-137 binds PTEN mRNA (Homo sapiens)
RHEA:45371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (9Z)-octadecenoate
REACT:R-MMU-2186767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SKI/SKIL (Mus musculus)
REACT:R-XTR-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Xenopus tropicalis)
REACT:R-HSA-5246444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A17 binds LCN2:2,5DHBA:Fe3+ (Homo sapiens)
REACT:R-DME-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Drosophila melanogaster)
RHEA:33193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA => a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA
REACT:R-SPO-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Schizosaccharomyces pombe)
RHEA:49029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-3322431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds TLE (Danio rerio)
REACT:R-RNO-4341070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PPARA with SUMO1 (Rattus norvegicus)
RHEA:51682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl phosphate + CDP + H(+) => (2E,6E)-farnesol + CTP
RHEA:53462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate => 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol
REACT:R-CFA-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Canis familiaris)
REACT:R-HSA-9029151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (Homo sapiens)
RHEA:48429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)
RHEA:39808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoate(in) => octadecanoate(out)
REACT:R-CFA-4724279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Canis familiaris)
RHEA:59342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-hydroxy-demethylspheroidene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A
RHEA:47841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine => (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate
RHEA:26542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-piperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + NH4(+)
REACT:R-BTA-3858489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds DAAM1 (Bos taurus)
RHEA:71076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-cystine(out) => L-arginine(out) + L-cystine(in)
REACT:R-MMU-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)
RHEA:34575	skos:prefLabel	"pentalenolactone synthase"
RHEA:34575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pentalenolactone synthase"
RHEA:34575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone
REACT:R-HSA-209840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two DITs combine to form thyroxine (Homo sapiens)
RHEA:46380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-8987230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Danio rerio)
REACT:R-MMU-2161620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by PTGDS (Mus musculus)
RHEA:69480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP
REACT:R-CFA-3928645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB:NMDAR binds TIAM1 (Canis familiaris)
RHEA:31280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate
REACT:R-XTR-9617927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO4 binds ATXN3 (Xenopus tropicalis)
REACT:R-HSA-3780958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) (Homo sapiens)
RHEA:18417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM3 (d18:1(4E)) + H(+)
RHEA:35988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-8944026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAI1,SNAI2 bind the PTEN gene promoter (Homo sapiens)
REACT:R-HSA-183130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Homo sapiens)
REACT:R-RNO-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Rattus norvegicus)
RHEA:61887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate
REACT:R-SCE-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Saccharomyces cerevisiae)
RHEA:43742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + hexanoyl-CoA => ATP + CoA + hexanoate
RHEA:51601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-5683964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates EYA1-4 (Bos taurus)
REACT:R-DDI-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Dictyostelium discoideum)
REACT:R-HSA-5654402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
RHEA:47393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoate ester => an aliphatic alcohol + H(+) + hexadecanoate
RHEA:13523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate => (R)-lactate + 2 Fe(III)-[cytochrome c]
REACT:R-PFA-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Plasmodium falciparum)
RHEA:52411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH
RHEA:37172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
RHEA:71847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate(out) = glycoursodeoxycholate(in)
RHEA:29817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-proline(in) + phosphate => ATP + H2O + L-proline(out)
REACT:R-DME-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Drosophila melanogaster)
RHEA:60145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-glutamyl-[protein] => ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate
RHEA:16566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidine => 3-(imidazol-5-yl)pyruvate + L-glutamate
REACT:R-DRE-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Danio rerio)
REACT:R-XTR-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Xenopus tropicalis)
REACT:R-DDI-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Dictyostelium discoideum)
REACT:R-CFA-5638333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)
RHEA:37778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DME-450802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZ and VANG bind to STAN homodimer (Drosophila melanogaster)
REACT:R-SCE-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Saccharomyces cerevisiae)
REACT:R-HSA-913370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Homo sapiens)
REACT:R-CFA-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Canis familiaris)
REACT:R-RNO-2024108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some HSPGs are secreted to the plasma membrane (Rattus norvegicus)
RHEA:44321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-decanoylglycerol + H2O => decanoate + glycerol + H(+)
REACT:R-XTR-9018859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Xenopus tropicalis)
REACT:R-CFA-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Canis familiaris)
GO:0102648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity
REACT:R-DDI-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Dictyostelium discoideum)
REACT:R-GGA-8866304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL binds lipids to form VLDL (Gallus gallus)
REACT:R-HSA-9694737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)
RHEA:53068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxyestrone + UDP-alpha-D-glucuronate = 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:46803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-5654628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS3 (Danio rerio)
REACT:R-CEL-1369028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid efflux (Caenorhabditis elegans)
REACT:R-MMU-2730870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
REACT:R-MMU-5689544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds INO80 complex (Mus musculus)
REACT:R-DRE-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Danio rerio)
REACT:R-SSC-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Sus scrofa)
REACT:R-HSA-5625774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Homo sapiens)
REACT:R-MMU-3249371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylates STAT6 at Ser407 (Mus musculus)
REACT:R-XTR-448678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTSG cleaves CASP1(1-404) (Xenopus tropicalis)
RHEA:49208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
REACT:R-HSA-381283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PPARG (Homo sapiens)
RHEA:61032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine = 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:38617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose => cyclic ADP-beta-D-ribose + H2O
RHEA:46172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate
REACT:R-BTA-8938770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Bos taurus)
RHEA:37061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA => adenosine(37) in tRNA + L-threonylcarbamoyladenylate
REACT:R-MMU-8936519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO2:FAD dimer reduces quinones to hydroquinones (Mus musculus)
REACT:R-HSA-71286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Homo sapiens)
RHEA:57621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]
GO:0047087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protopine 6-monooxygenase activity
GO:0047087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)
GO:0047087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protopine 6-hydroxylase activity
RHEA:24610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate + CO2 + H2O => 5-dehydro-4-deoxy-D-glucarate + H(+)
REACT:R-DDI-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Dictyostelium discoideum)
REACT:R-DDI-3465545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Dictyostelium discoideum)
GO:0052692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raffinose-specific alkaline alpha-galactosidase activity
GO:0052692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raffinose alpha-galactosidase activity
GO:0052692	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alkaline alpha-galactosidase activity
GO:0052692	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	raffinose galactohydrolase activity
REACT:R-SSC-420977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca permeable AMPA receptor ligand binding (Sus scrofa)
RHEA:48725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin B + H(+) + H2O => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide
REACT:R-SSC-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Sus scrofa)
REACT:R-DME-3828025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP14 (Drosophila melanogaster)
RHEA:57573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Saccharomyces cerevisiae)
RHEA:44213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxytetradecanoate + ATP + CoA => 3-hydroxytetradecanoyl-CoA + AMP + diphosphate
REACT:R-DDI-1482868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Dictyostelium discoideum)
REACT:R-HSA-2187309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer binds SP1 (Homo sapiens)
RHEA:28181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate <=> colnelenate + H2O
REACT:R-GGA-72095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internal Methylation of mRNA (Gallus gallus)
RHEA:17748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP
RHEA:46814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH
RHEA:59151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + marinolate C <=> AMP + diphosphate + marinoloyl-CoA C
RHEA:35259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate
GO:0062150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amorpha-4,11-diene 12-monooxygenase activity
GO:0062150	skos:altLabel	"CYP71AV1"
GO:0062150	skos:prefLabel	"amorpha-4,11-diene 12 monooxygenase"
GO:0062150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amorpha-4,11-diene 12 monooxygenase"
GO:0062150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:33581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate
RHEA:40749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2
REACT:R-SSC-2130378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex to plasma membrane (Sus scrofa)
REACT:R-DRE-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Danio rerio)
REACT:R-DDI-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Dictyostelium discoideum)
REACT:R-GGA-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Gallus gallus)
RHEA:18371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + H2O2 => O2 + sn-glycerol 3-phosphate
REACT:R-DME-199443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Drosophila melanogaster)
RHEA:48554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => 1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O
RHEA:38409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O
RHEA:19453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-alanine = L-glutamate + pyruvate
RHEA:19453	skos:altLabel	"alanine aminotransferase"
RHEA:19453	skos:altLabel	"glutamic--alanine transaminase"
RHEA:19453	skos:prefLabel	"alanine transaminase"
RHEA:19453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alanine transaminase"
RHEA:19453	skos:altLabel	"glutamic--pyruvic transaminase"
REACT:R-HSA-9624112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK4 (Homo sapiens)
REACT:R-DME-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Drosophila melanogaster)
REACT:R-SSC-8870489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA4,(5,6) bind PI3P (Sus scrofa)
RHEA:63949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphinga-4E,14Z-dienine-1-phosphate => phosphate + sphinga-4E,14Z-dienine
REACT:R-GGA-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Gallus gallus)
REACT:R-MMU-804969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B1 hydrogenates E1 to EST17b (Mus musculus)
RHEA:46137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminopyrrolnitrin + H(+) + NADPH + 2 O2 => 2 H2O + NADP(+) + pyrrolnitrin
GO:0016793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triphosphoric monoester hydrolase activity
REACT:R-HSA-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
REACT:R-GGA-83723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Gallus gallus)
REACT:R-MMU-5675456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer (Mus musculus)
REACT:R-MMU-9632033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GalNAc to chondroitin (Mus musculus)
REACT:R-HSA-8948066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-IRAK1 dissociates (Homo sapiens)
REACT:R-SSC-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Sus scrofa)
REACT:R-SPO-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Schizosaccharomyces pombe)
REACT:R-CEL-5693742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH hydrolyses AEA to AA and ETA (Caenorhabditis elegans)
REACT:R-RNO-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Rattus norvegicus)
RHEA:72390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + sulfate(in) <=> 2 hydrogencarbonate(in) + sulfate(out)
GO:0032404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mismatch repair complex binding
RHEA:60057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)
RHEA:60204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate
REACT:R-DDI-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Dictyostelium discoideum)
RHEA:48836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
REACT:R-HSA-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Homo sapiens)
REACT:R-RNO-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Rattus norvegicus)
RHEA:46030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate
REACT:R-DRE-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Danio rerio)
RHEA:37800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADH + O2 => 2 H2O + 2 NAD(+)
GO:0017128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipid scramblase activity
REACT:R-CEL-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Caenorhabditis elegans)
REACT:R-XTR-174374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 from MeCbl to HCYS (Xenopus tropicalis)
REACT:R-HSA-9645134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from activator:STAT5 complex (Homo sapiens)
REACT:R-BTA-2161907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Bos taurus)
RHEA:42874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine => N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine
REACT:R-SSC-427645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A3 cotransports Pi, 2Na+ (Sus scrofa)
REACT:R-SSC-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Sus scrofa)
REACT:R-CEL-111238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR2  homodimer (Caenorhabditis elegans)
REACT:R-RNO-8853774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Rattus norvegicus)
RHEA:26210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine => acetaldehyde + glycine
RHEA:44142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + CO2 + reduced [flavodoxin] => CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate
RHEA:61828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stigmasterol + UDP-alpha-D-glucose = H(+) + stigmasteryl 3-beta-D-glucoside + UDP
REACT:R-SSC-9731632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)
REACT:R-GGA-5692775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Gallus gallus)
REACT:R-DRE-4615905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO1 (Danio rerio)
REACT:R-HSA-164381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
REACT:R-MMU-6814764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasma membrane resorption (Mus musculus)
GO:0043823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spheroidene monooxygenase activity
RHEA:37462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + ATP <=> 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
REACT:R-GGA-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Gallus gallus)
GO:0050049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-leucine:NAD+ oxidoreductase, deaminating
GO:0050049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leucine dehydrogenase"
GO:0050049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)
GO:0050049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-leucine dehydrogenase activity
GO:0050049	skos:prefLabel	"leucine dehydrogenase"
GO:0050049	skos:altLabel	"LeuDH"
GO:0050049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-leucine:NAD+ oxidoreductase (deaminating)
GO:0050049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LeuDH activity
GO:0050049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucine dehydrogenase activity
REACT:R-HSA-9749471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
RHEA:30564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-tryptophan => 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate
REACT:R-HSA-9010898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO2 binds SLIT2 (Homo sapiens)
REACT:R-XTR-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Xenopus tropicalis)
RHEA:35935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + L-proline + L-tryptophan = 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)
RHEA:39355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)
REACT:R-GGA-2454081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5 oxidises 11cROL to 11cRAL (Gallus gallus)
REACT:R-MMU-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Mus musculus)
RHEA:47013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-disulfide + H(+) + hydrogen sulfide => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine
REACT:R-CEL-5251942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hikeshi binds HSP70s:ATP (Caenorhabditis elegans)
RHEA:33853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine => GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol)
REACT:R-BTA-9605644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Bos taurus)
RHEA:57733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-7,8-dihydroretinol => AH2 + all-trans-retinol
REACT:R-SSC-8944223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type V (Sus scrofa)
RHEA:22229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + presqualene diphosphate => diphosphate + NAD(+) + squalene
RHEA:15674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + H2O => acetoacetate + CoA + H(+)
REACT:R-SSC-418172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB2 (Sus scrofa)
REACT:R-BTA-5250209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP binds SLC25A4 (Bos taurus)
RHEA:25428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-hexosamine = ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate
RHEA:45937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-DRE-6783556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIFR:JAKs bind gp130:JAKs:CNTFR (Danio rerio)
GO:0005522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	profilin binding
REACT:R-MMU-8983983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Mus musculus)
REACT:R-PFA-9018868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Plasmodium falciparum)
RHEA:53573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102811	skos:altLabel	"CYP76B6"
GO:0102811	skos:altLabel	"G10H"
GO:0102811	skos:prefLabel	"geraniol 8-hydroxylase"
GO:0102811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geraniol 8-hydroxylase"
GO:0102811	skos:altLabel	"CYP76B10"
GO:0102811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geraniol 10-hydroxylase activity
RHEA:44609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-8854612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 accelerates GTP hydrolysis by RAB33B (Danio rerio)
REACT:R-DRE-5654679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR3 (Danio rerio)
GO:0045029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled UDP receptor activity
GO:0045029	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	UDP-activated nucleotide receptor activity
REACT:R-SPO-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Schizosaccharomyces pombe)
REACT:R-BTA-5685838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex binds D-loop structures (Bos taurus)
REACT:R-MMU-8937613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHBP binds CRH (Mus musculus)
REACT:R-HSA-141367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylation of tBID by NMT1 (Homo sapiens)
REACT:R-MMU-2534388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone Activation Of CatSper (Mus musculus)
RHEA:47622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethylhexanal + CO2 + H(+) + succinate + sulfate => 2-ethylhexyl sulfate + 2-oxoglutarate + O2
REACT:R-HSA-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Homo sapiens)
REACT:R-SSC-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Sus scrofa)
RHEA:36360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a plastoquinone + 2 H2O + 4 hnu => 2 a plastoquinol + O2
GO:0050699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WW domain binding
GO:0140587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin loop anchoring activity
GO:0140587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromosomal loop binding
GO:0140587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA loop binding
REACT:R-MMU-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Mus musculus)
RHEA:39308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH => (11Z,14Z)-eicosadienoyl-CoA + NADP(+)
RHEA:37364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O
RHEA:14840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + O2 <=> H(+) + H2O2 + oxalate
RHEA:39106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sitosterol(in) <=> ADP + H(+) + phosphate + sitosterol(out)
REACT:R-DRE-904864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Danio rerio)
RHEA:39736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Bos taurus)
GO:0008667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity
GO:0008667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
GO:0008667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-DHB dehydrogenase activity
RHEA:19573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + ATP = [phosphate](n+1) + ADP
RHEA:19573	skos:altLabel	"polyphosphate kinase"
RHEA:19573	skos:prefLabel	"ATP-polyphosphate phosphotransferase"
RHEA:19573	skos:altLabel	"polyphosphoric acid kinase"
RHEA:19573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ATP-polyphosphate phosphotransferase"
RHEA:31121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-methylbut-2-enoyl-CoA + H2O => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA
RHEA:13141	skos:prefLabel	"isobutyryl-CoA mutase"
RHEA:13141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isobutyryl-CoA mutase"
RHEA:13141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA = butanoyl-CoA
RHEA:40340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)
GO:0042943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-amino acid transmembrane transporter activity
GO:0042943	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-amino acid transporter activity
RHEA:46811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine <=> [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine
RHEA:15210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH
REACT:R-BTA-2530453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vitronectin (VTN) binds to C5b:C6:C7 (Bos taurus)
REACT:R-SSC-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Sus scrofa)
REACT:R-XTR-420214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The adrenomedullin receptor can bind adrenomedullin and intermedin (Xenopus tropicalis)
REACT:R-HSA-416723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA6A binds to PLXNA2 and PLXNA4 (Homo sapiens)
RHEA:60521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-cystine-bis-glycine => 2 glycine + L-cystine
REACT:R-CEL-373705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of DCC (Caenorhabditis elegans)
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histo-blood substance beta-dependent galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucosylgalactoside 3-alpha-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fucosylglycoprotein 3-alpha-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histo-blood group B transferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	[blood group substance] alpha-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	blood-group substance beta-dependent galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histo-blood substance B-dependent galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	B transferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity
GO:0004381	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	blood-group substance B-dependent galactosyltransferase activity
RHEA:48896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:48896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] = 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:48896	skos:altLabel	"cyano-type divinyl chlorophyllide a 8-vinyl-reductase"
RHEA:48896	skos:prefLabel	"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin)"
RHEA:48896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin)"
GO:0106008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate amidase activity
RHEA:39678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA
REACT:R-BTA-176631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Bos taurus)
GO:0048029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monosaccharide binding
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	putrescine acetyltransferase activity
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spermidine/spermine N1-acetyltransferase activity
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	putrescine N-acetyltransferase activity
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diamine acetyltransferase activity
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	spermine acetyltransferase
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diamine N-acetyltransferase"
GO:0004145	skos:prefLabel	"diamine N-acetyltransferase"
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	spermidine N(1)-acetyltransferase activity
GO:0004145	skos:altLabel	"spermidine acetyltransferase"
GO:0004145	skos:altLabel	"diamine acetyltransferase"
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	spermine N(1)-acetyltransferase
GO:0004145	skos:altLabel	"putrescine (diamine)-acetylating enzyme"
GO:0004145	skos:altLabel	"spermidine N(1)-acetyltransferase"
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity
GO:0004145	skos:altLabel	"putrescine acetyltransferase"
GO:0004145	skos:altLabel	"putrescine N-acetyltransferase"
GO:0004145	skos:altLabel	"acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase"
GO:0004145	skos:altLabel	"putrescine acetylase"
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	putrescine (diamine)-acetylating enzyme activity
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	putrescine acetylase activity
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	spermidine acetyltransferase activity
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diamine N-acetyltransferase activity
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spermine N-acetyltransferase
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity
GO:0004145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spermidine N1-acetyltransferase activity
REACT:R-GGA-8876312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Gallus gallus)
RHEA:46551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine
RHEA:44347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide A + H(+) + phosphate
RHEA:56399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)
RHEA:26320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate
RHEA:56820	skos:prefLabel	"cyclooctat-9-en-7-ol 5-monooxygenase"
RHEA:56820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclooctat-9-en-7-ol 5-monooxygenase"
RHEA:56820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cyclooctat-9-en-7-ol + O2 = A + cyclooctat-9-ene-5,7-diol + H2O
REACT:R-DRE-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Danio rerio)
REACT:R-DME-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Drosophila melanogaster)
REACT:R-SSC-420265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind IAPP(34-70) (Sus scrofa)
RHEA:67735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridylyl-uridylyl-ribonucleotide-RNA <=> a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA
RHEA:34426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-secoisolariciresinol + NADP(+) <=> (+)-lariciresinol + H(+) + NADPH
RHEA:58913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + iron(III) dicitrate(out) => ADP + H(+) + iron(III) dicitrate(in) + phosphate
RHEA:15976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + estrone <=> adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)
REACT:R-XTR-8854908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates RET:GDNF:GFRA dimer (Xenopus tropicalis)
RHEA:16100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylpyruvate + H2O <=> acetate + H(+) + pyruvate
REACT:R-HSA-1168394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 tyrosine phosphorylation (Homo sapiens)
RHEA:47663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-methionine sulfoximine <=> CoA + H(+) + N-acetyl-L-methionine sulfoximine
REACT:R-RNO-202718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Rattus norvegicus)
REACT:R-GGA-173626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1r (Gallus gallus)
REACT:R-SSC-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Sus scrofa)
RHEA:35213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + H(+) + phosphate => dIDP + H2O
RHEA:31887	skos:prefLabel	"tirucalladienol synthase"
RHEA:31887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = tirucalladienol
RHEA:31887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tirucalladienol synthase"
RHEA:29584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(in) + H(+)(out) => guanosine(out) + H(+)(in)
REACT:R-HSA-5228523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates MDM2 with SUMO1 (Homo sapiens)
REACT:R-BTA-1222491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoferrin scavenges iron ions (Bos taurus)
RHEA:49092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate
GO:0001735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prenylcysteine lyase activity
GO:0001735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenylcysteine oxidase activity
GO:0001735	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-prenyl-L-cysteine:oxygen oxidoreductase activity
REACT:R-HSA-8877485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1 (Homo sapiens)
REACT:R-BTA-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Bos taurus)
REACT:R-CEL-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Caenorhabditis elegans)
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-fructofuranosidase activity
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructofuranoside fructohydrolase activity
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	invertin activity
GO:0004564	skos:altLabel	"saccharase"
GO:0004564	skos:prefLabel	"beta-fructofuranosidase"
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maxinvert L 1000 activity
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructosylinvertase activity
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	saccharase activity
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosucrase activity
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acid invertase activity
GO:0004564	skos:altLabel	"invertase"
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	invertase activity
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-fructosidase activity
GO:0004564	skos:altLabel	"beta-fructosidase"
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-fructofuranosidase"
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-h-fructosidase activity
GO:0004564	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alkaline invertase activity
RHEA:60415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monoglucosyl-enterobactin <=> [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)
REACT:R-GGA-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Gallus gallus)
RHEA:38337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + 2 D-glucose => (20S)-ginsenoside Rb1 + 2 H2O
REACT:R-HSA-6794347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 dimerizes (Homo sapiens)
RHEA:52171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0017169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alcohol phosphatidyltransferase activity
REACT:R-DRE-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)
RHEA:61304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP
GO:0097655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serpin family protein binding
REACT:R-SCE-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Saccharomyces cerevisiae)
REACT:R-GGA-216076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Gallus gallus)
RHEA:45672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-SSC-170126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin B1 in the CRS domain (Sus scrofa)
RHEA:36429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine
REACT:R-GGA-4641236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates FZD to potentiate WNT signaling (Gallus gallus)
REACT:R-DRE-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Danio rerio)
REACT:R-MMU-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Mus musculus)
REACT:R-CFA-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-DRE-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Danio rerio)
REACT:R-HSA-8948234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB:4-Hyp collagen propeptides dissociates (Homo sapiens)
REACT:R-DRE-6805109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates TP53 (Danio rerio)
GO:0008083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth factor activity
REACT:R-CFA-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Canis familiaris)
REACT:R-RNO-372693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
GO:0033708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PH1722
GO:0033708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate-homoisocitrate dehydrogenase activity
GO:0033708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity
GO:0033708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoisocitrate-isocitrate dehydrogenase activity
REACT:R-SPO-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Schizosaccharomyces pombe)
RHEA:10266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose => alpha-D-glucose
REACT:R-HSA-389919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds pBTLA (Homo sapiens)
REACT:R-GGA-1362465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GHR (Gallus gallus)
RHEA:15740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopentanone + H(+) + NADPH + O2 <=> 5-valerolactone + H2O + NADP(+)
REACT:R-GGA-5607737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 oligomerizes (Gallus gallus)
REACT:R-CFA-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)
REACT:R-MMU-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Mus musculus)
RHEA:29351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zn(2+)(in) = Zn(2+)(out)
REACT:R-BTA-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Bos taurus)
RHEA:10501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + glyoxylate + H2O => 3-ethylmalate + CoA + H(+)
RHEA:37478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-XTR-873919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Xenopus tropicalis)
REACT:R-SSC-6810464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT14 hydrolyses UDP-Glc to G1P and UMP (Sus scrofa)
REACT:R-SSC-6806732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface (Sus scrofa)
RHEA:61508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peonidin + UDP-alpha-D-glucose = peonidin 3-O-beta-D-glucoside + UDP
RHEA:44340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumarate--(S)-2,3-diaminopropanoate ligase"
RHEA:44340	skos:prefLabel	"fumarate--(S)-2,3-diaminopropanoate ligase"
RHEA:44340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + ATP + fumarate = AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate
RHEA:14988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-DME-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Drosophila melanogaster)
RHEA:55848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA
RHEA:33697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosasphinganine + H(+) + NADPH => C20 sphinganine + NADP(+)
RHEA:10926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide
REACT:R-MMU-443978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR11 binds CCL19, CCL21 & CCL25 (Mus musculus)
RHEA:61595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine
REACT:R-RNO-8987156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Rattus norvegicus)
REACT:R-DME-110459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 dephosphorylated to PIP2 by DPTEN (Drosophila melanogaster)
RHEA:58551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine
RHEA:26392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + O2 <=> all-trans-10'-apo-beta-carotenal + beta-ionone
RHEA:14073	skos:prefLabel	"hydroxyglutamate decarboxylase"
RHEA:14073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyglutamate decarboxylase"
RHEA:14073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO2
RHEA:14073	skos:altLabel	"3-hydroxy-L-glutamate 1-carboxy-lyase"
REACT:R-SPO-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Schizosaccharomyces pombe)
RHEA:36242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + phosphate
REACT:R-SSC-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Sus scrofa)
REACT:R-SSC-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Sus scrofa)
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanyl-transfer RNA synthetase activity
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine translase activity
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanyl-transfer ribonucleic acid synthetase activity
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AlaRS
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine:tRNAAla ligase (AMP-forming)
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ala-tRNA synthetase activity
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine-tRNA ligase activity
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanyl-transfer ribonucleate synthetase activity
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanyl-tRNA synthetase activity
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanyl-transfer ribonucleate synthase activity
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine transfer RNA synthetase activity
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine tRNA synthetase activity
GO:0004813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-transfer RNA ligase activity
REACT:R-GGA-9023627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)
REACT:R-DRE-4420143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SH2D2A (Danio rerio)
REACT:R-GGA-561072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal uptake of organic cations (Gallus gallus)
RHEA:17340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + O2 <=> (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)
REACT:R-DME-3697882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)
REACT:R-GGA-3769393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ binds p-CBY:CTNNB1 (Gallus gallus)
REACT:R-CEL-5661114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Caenorhabditis elegans)
RHEA:49966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + phenazine => 5,10-dihydrophenazine + O2
RHEA:49635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate <=> (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)
RHEA:47339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:49839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5E)-tetradecenoyl-CoA + (R)-carnitine <=> (5E)-tetradecenoyl-(R)-carnitine + CoA
REACT:R-MMU-629588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Mus musculus)
RHEA:43010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + H2O => D-serine
REACT:R-HSA-8981443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)
RHEA:13873	skos:altLabel	"abietadiene synthase"
RHEA:13873	skos:prefLabel	"abieta-7,13-diene synthase"
RHEA:13873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate
RHEA:13873	skos:altLabel	"abietadiene cyclase"
RHEA:13873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"abieta-7,13-diene synthase"
REACT:R-CEL-186826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to the active receptor (Caenorhabditis elegans)
RHEA:38953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out) => ATP + H2O + sphing-4-enine 1-phosphate(in)
REACT:R-RNO-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Rattus norvegicus)
REACT:R-CFA-6781897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP11 deubiquitinates NFKBIA (Canis familiaris)
RHEA:58720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nicotine + NADPH + O2 = H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide
REACT:R-CEL-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Caenorhabditis elegans)
REACT:R-MMU-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Mus musculus)
REACT:R-SSC-74712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of IRS-P from insulin receptor (Sus scrofa)
REACT:R-BTA-8858369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVRL1 binds BMP9,BMP10 (Bos taurus)
REACT:R-DRE-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Danio rerio)
RHEA:69246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfinylpentyl nitrile + sulfate + sulfur => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate
REACT:R-HSA-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Homo sapiens)
REACT:R-DDI-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Dictyostelium discoideum)
REACT:R-DDI-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Dictyostelium discoideum)
REACT:R-RNO-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)
REACT:R-CFA-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Canis familiaris)
RHEA:61864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dehydroprobetaenone I = A + probetaenone I
RHEA:65903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + glyoxylate <=> glycine + H2O + xanthurenate
REACT:R-DME-5655170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 monoubiquitinates POLH (Drosophila melanogaster)
GO:0035527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate dehydrogenase (NADP+) activity
GO:0035527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxypropanoate:NADP+ oxidoreductase
GO:0035527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxypropionate:NADP+ oxidoreductase
GO:0035527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropionate dehydrogenase (NADP+) activity
RHEA:38952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sphing-4-enine 1-phosphate(in) => ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)
REACT:R-SPO-109863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK3:MAP2K1 (Schizosaccharomyces pombe)
REACT:R-XTR-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Xenopus tropicalis)
RHEA:50170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2
REACT:R-DDI-381135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)
RHEA:69629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-MMU-5602295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F22 20-hydroxylates TrXA3 (Mus musculus)
REACT:R-HSA-8877620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE2 cleaves EDN1(53-90) (Homo sapiens)
REACT:R-BTA-173512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Bos taurus)
RHEA:65551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside Fuc-GM1 + H2O <=> alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base
RHEA:12062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O => acetyl-CoA + 5 H(+) + 6 malonyl-CoA
RHEA:29825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) => chloride(in)
RHEA:29769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-methionine(in) + H(+) + phosphate => ATP + D-methionine(out) + H2O
REACT:R-HSA-9610195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2D (GRIN2D) (Homo sapiens)
REACT:R-DRE-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Danio rerio)
RHEA:46900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)
RHEA:21769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methyl-L-alanine + NADP(+) => H(+) + methylamine + NADPH + pyruvate
GO:0033929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	blood-group-substance 1,4-beta-D-galactanohydrolase activity
GO:0033929	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-beta-galactosidase activity
GO:0033929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	blood-group-substance endo-1,4-beta-galactosidase activity
GO:0031530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GnRH receptor binding
GO:0031530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gonadotropin-releasing hormone receptor binding
GO:0031530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gonadotrophin-releasing hormone receptor binding
REACT:R-XTR-158849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phenol can form a sulfate conjugate (Xenopus tropicalis)
RHEA:42675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-L-cysteine + hercynine + O2 <=> gamma-L-glutamyl-hercynylcysteine S-oxide + H2O
RHEA:33431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate
RHEA:33431	skos:altLabel	"4-oxalocrotonate isomerase"
RHEA:33431	skos:altLabel	"4-oxalocrotonate tautomerase"
RHEA:33431	skos:prefLabel	"2-hydroxymuconate tautomerase"
RHEA:33431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxymuconate tautomerase"
RHEA:31886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> delta-amyrin
GO:0008907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transesterification to connect viral DNA 3' ends to host DNA 5' ends (Homo sapiens)
GO:0008907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	integrase activity
GO:0106239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,13-epoxylabda-14-ene synthase activity
REACT:R-GGA-3000335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Gallus gallus)
REACT:R-DRE-167419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex releases GDP (Danio rerio)
REACT:R-DRE-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Danio rerio)
RHEA:57253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP => glycolate + GTP + H(+)
REACT:R-HSA-445071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reinsertion of L1 into the plasma membrane (Homo sapiens)
REACT:R-CEL-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Caenorhabditis elegans)
REACT:R-CEL-74220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Caenorhabditis elegans)
REACT:R-HSA-5692761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JUN binds MAPK6 gene (Homo sapiens)
REACT:R-HSA-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)
GO:0050312	skos:prefLabel	"Carbon-sulfur lyases"
GO:0050312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carbon-sulfur lyases"
GO:0050312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfoacetaldehyde lyase activity
GO:0050312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphoacetaldehyde lyase activity
RHEA:52860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty acid + ATP + CoA = a short-chain fatty acyl-CoA + AMP + diphosphate
REACT:R-RNO-2046097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)
REACT:R-MMU-354149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
RHEA:50955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloro-L-tryptophan + AH2 + O2 <=> A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin
REACT:R-PFA-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Plasmodium falciparum)
REACT:R-DME-8936851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHRR binds ARNT (Drosophila melanogaster)
REACT:R-MMU-2328033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds latent TGF-beta (Mus musculus)
REACT:R-SPO-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Schizosaccharomyces pombe)
REACT:R-BTA-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Bos taurus)
RHEA:72780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + O2 + ochratoxin B => FAD + 2 H2O + ochratoxin A
RHEA:69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermine monoaldehyde = acrolein + spermidine
REACT:R-CEL-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Caenorhabditis elegans)
RHEA:33460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + zymosterone => NADP(+) + zymosterol
REACT:R-CEL-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Caenorhabditis elegans)
GO:0004153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydropterin deaminase activity
REACT:R-HSA-9616241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds the promoter of the CEBPE gene (Homo sapiens)
RHEA:24207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + H(+) + sulfite <=> phosphate + sulfoacetaldehyde
RHEA:13633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + putrescine = ADP + gamma-L-glutamylputrescine + H(+) + phosphate
RHEA:13633	skos:altLabel	"gamma-glutamylputrescine synthetase"
RHEA:13633	skos:prefLabel	"glutamate--putrescine ligase"
RHEA:13633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate--putrescine ligase"
GO:0045290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinose:NAD(P)+ 1-oxidoreductase activity
GO:0045290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose 1-dehydrogenase [NAD(P)+] activity
GO:0005543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipid binding
RHEA:32744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + O-acetyl-L-serine => acetate + H(+) + L,L-cystathionine
REACT:R-HSA-5144542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLOCK acetylates lysine-15 of histone H3, H4 (Homo sapiens)
REACT:R-MMU-380283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Mus musculus)
RHEA:63333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-arabinopyanose => beta-L-arabinopyranose
REACT:R-SCE-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Saccharomyces cerevisiae)
REACT:R-SCE-8869627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NR to yield NMN (Saccharomyces cerevisiae)
RHEA:10128	skos:altLabel	"NSY"
RHEA:10128	skos:prefLabel	"neoxanthin synthase"
RHEA:10128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin = all-trans-neoxanthin
RHEA:10128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neoxanthin synthase"
REACT:R-BTA-4615839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO2,3 (Bos taurus)
RHEA:15804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
REACT:R-GGA-352136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Gallus gallus)
RHEA:59823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP <=> adenosine 3'-diphosphate,5'-triphosphate + AMP
REACT:R-CFA-5654163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds PLCG1 (Canis familiaris)
RHEA:56598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1S,4S)-bornane-2,5-dione + FMNH2 + O2
RHEA:48413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside IV3GalNAc-Gb4Cer + H2O => globoside Gb4Cer + N-acetyl-alpha-D-galactosamine
RHEA:63511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + O2 <=> a (2R)-2-hydroperoxy fatty acid
REACT:R-GGA-417858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y14 receptor can bind to UDP-glucose (Gallus gallus)
RHEA:38124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol => 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA
RHEA:65767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O <=> (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)
REACT:R-SSC-8870352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Sus scrofa)
GO:0032563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dADP binding
GO:0102620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity
REACT:R-MMU-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
RHEA:45336	skos:altLabel	"porcupine"
RHEA:45336	skos:prefLabel	"[Wnt protein] O-palmitoleoyl transferase"
RHEA:45336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA
RHEA:45336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[Wnt protein] O-palmitoleoyl transferase"
GO:0070566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyltransferase activity
REACT:R-HSA-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Homo sapiens)
REACT:R-SSC-9707523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to BACH1:MAFK (Sus scrofa)
RHEA:18600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [rubredoxin] <=> NADH + 2 oxidized [rubredoxin]
REACT:R-RNO-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Rattus norvegicus)
REACT:R-CFA-194518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoA is activated by nucleotide exchange and inhibits axonal growth (Canis familiaris)
GO:0102471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxynaringenin-6C-glucoside dehydratase activity
RHEA:35246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + thiamine diphosphate <=> adenosine thiamine triphosphate + phosphate
REACT:R-MMU-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Mus musculus)
RHEA:58737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + TTP => 5-methyl-UMP + diphosphate + H(+)
REACT:R-MMU-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Mus musculus)
RHEA:12614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + L-cystine => glutathione disulfide + 2 L-cysteine
REACT:R-SSC-5686642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD52 promotes single strand annealing at resected DNA DSBs (Sus scrofa)
REACT:R-DRE-216082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaXbeta2 with fibrin (Danio rerio)
GO:0015189	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histidine/arginine/lysine/ornithine porter activity
GO:0015189	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine permease activity
GO:0015189	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine permease
GO:0015189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine transmembrane transporter activity
REACT:R-XTR-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Xenopus tropicalis)
REACT:R-XTR-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Xenopus tropicalis)
RHEA:47762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 21S rRNA + S-adenosyl-L-methionine
REACT:R-MMU-2396399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillins bind BMPs (Mus musculus)
RHEA:72426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-AMP + CoA <=> (E)-4-coumaroyl-CoA + AMP + H(+)
REACT:R-MMU-9026005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Mus musculus)
RHEA:12276	skos:prefLabel	"isovaleryl-CoA dehydrogenase"
RHEA:12276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:12276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isovaleryl-CoA dehydrogenase"
GO:0032033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin II light chain binding
REACT:R-BTA-217255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO1:FAD N-oxidises TAM (Bos taurus)
REACT:R-DRE-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Danio rerio)
REACT:R-XTR-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
RHEA:64759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-benzyl-L-cysteine <=> benzylthiol + NH4(+) + pyruvate
EC:5.99.-.-	skos:prefLabel	"Other isomerases"
EC:5.99.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other isomerases"
REACT:R-CFA-6809680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTM1 (Canis familiaris)
REACT:R-MMU-917807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Mus musculus)
RHEA:68257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine(in) + Na(+)(in) => L-cystine(out) + Na(+)(out)
REACT:R-DDI-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Dictyostelium discoideum)
REACT:R-DRE-202727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaMbeta2 (MAC1) binds JAM3 (Danio rerio)
REACT:R-DME-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Drosophila melanogaster)
GO:0036033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mediator complex binding
REACT:R-HSA-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Homo sapiens)
REACT:R-HSA-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Homo sapiens)
REACT:R-HSA-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Homo sapiens)
REACT:R-CFA-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Canis familiaris)
RHEA:44666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O
REACT:R-CFA-76475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Canis familiaris)
RHEA:16611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate
RHEA:34265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + fumigaclavine C => dimethylallyl diphosphate + fumigaclavine A
RHEA:48869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADH => AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide
REACT:R-RNO-9014449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the plasma membrane (Rattus norvegicus)
RHEA:25200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O <=> 5-amino-6-(D-ribitylamino)uracil + phosphate
RHEA:16596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine <=> 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-1912379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of fringe-modified NOTCH to plasma membrane (Gallus gallus)
RHEA:27593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + ADP + H(+) + phosphate
RHEA:26175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA <=> CoA + H(+) + mycothiol
RHEA:17300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA
REACT:R-BTA-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Bos taurus)
REACT:R-MMU-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)
REACT:R-CFA-2022052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Canis familiaris)
RHEA:72564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) + dehydroepiandrosterone 3-sulfate(in) => butanoate(in) + dehydroepiandrosterone 3-sulfate(out)
REACT:R-DDI-2161948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Dictyostelium discoideum)
REACT:R-MMU-450550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCalpha phosphorylates HuR (Mus musculus)
RHEA:35164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + minocycline(in) => H(+)(in) + minocycline(out)
RHEA:54425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartyl-[protein] + NAD(+) => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide
REACT:R-DME-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Drosophila melanogaster)
RHEA:31344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate
REACT:R-GGA-8875540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 recruits CRK,CRKL to MET (Gallus gallus)
RHEA:64062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenyl-1,2-propanedione + H(+) + NADH => (S)-phenylacetylcarbinol + NAD(+)
RHEA:45108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Dictyostelium discoideum)
RHEA:42984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate = diphosphate + pimara-8(14),15-diene
RHEA:42984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pimaradiene synthase"
RHEA:42984	skos:prefLabel	"pimaradiene synthase"
RHEA:27400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-demethylrebeccamycin + H2O <=> beta-D-glucose + dichloroarcyriaflavin A
REACT:R-CFA-6787533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Canis familiaris)
REACT:R-DME-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Drosophila melanogaster)
REACT:R-SSC-211224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with DFF45 (Sus scrofa)
REACT:R-CFA-351936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of claspin (Canis familiaris)
RHEA:18205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"progesterone 11alpha-monooxygenase"
RHEA:18205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O
RHEA:18205	skos:prefLabel	"progesterone 11alpha-monooxygenase"
RHEA:18205	skos:altLabel	"progesterone 11alpha-hydroxylase"
RHEA:65172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z,5E)-dodecadienoyl-CoA + H2O = (3Z,5E)-dodecadienoate + CoA + H(+)
REACT:R-XTR-9661432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds ALB (Xenopus tropicalis)
REACT:R-MMU-2562541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR4-induced ripoptosome assembly (Mus musculus)
RHEA:46065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-202541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)
RHEA:13032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-glucosaminate
RHEA:38126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA
REACT:R-SSC-5694494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AACS ligates CoA-SH to ACA, forming ACA-CoA (Sus scrofa)
REACT:R-XTR-3662335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates histone H2A, H2B, H3, H4 (Xenopus tropicalis)
REACT:R-HSA-1295613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds GRB2 (Homo sapiens)
REACT:R-DRE-5672961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates inactive RAFs (Danio rerio)
REACT:R-DDI-8948018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Dictyostelium discoideum)
REACT:R-HSA-1183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Adiponectin (Homo sapiens)
REACT:R-SSC-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)
RHEA:34183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-abequose:alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase"
RHEA:34183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose = alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)
RHEA:34183	skos:prefLabel	"CDP-abequose:alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase"
RHEA:34183	skos:altLabel	"abequosyltransferase"
RHEA:34183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)
RHEA:33781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,6-kestotetraose + beta-D-glucose => 6-kestotriose + sucrose
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent glyceraldehyde phosphate dehydrogenase activity
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-triose phosphate dehydrogenase activity
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triosephosphate dehydrogenase (NADP+) activity
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triosephosphate dehydrogenase (NADP)
GO:0047100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triosephosphate dehydrogenase (NADP(+)) activity
RHEA:51704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthohumol = 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine
RHEA:51704	skos:prefLabel	"xanthohumol 4-O-methyltransferase"
RHEA:51704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xanthohumol 4-O-methyltransferase"
RHEA:28396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-D-glutamate => L-alanyl-L-glutamate
REACT:R-SCE-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Saccharomyces cerevisiae)
REACT:R-HSA-4546386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)
REACT:R-CEL-5263616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)
REACT:R-CEL-937311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP12A:ATP4B exchanges K+ for H+ (Caenorhabditis elegans)
REACT:R-SSC-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Sus scrofa)
RHEA:45840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydecanoyl-CoA + NADP(+) = 3-oxodecanoyl-CoA + H(+) + NADPH
REACT:R-HSA-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Homo sapiens)
REACT:R-HSA-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Homo sapiens)
RHEA:18191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) => [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose
RHEA:65814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2
REACT:R-MMU-193713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Mus musculus)
RHEA:20598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-cysteine + NAD(+) => H(+) + L-cystine + NADH
RHEA:31699	skos:prefLabel	"pentalenene oxygenase"
RHEA:31699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pentalenene oxygenase"
RHEA:31699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al
REACT:R-DRE-5607725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Danio rerio)
REACT:R-BTA-76426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-atom dealkylation of caffeine (Bos taurus)
RHEA:67683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + H2O <=> a long-chain fatty acid + CoA + H(+)
RHEA:16822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NAD(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADH
REACT:R-BTA-975185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Bos taurus)
REACT:R-RNO-202129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds eNOS:Caveolin-1:CaM complex (Rattus norvegicus)
RHEA:56865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)
RHEA:69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + cremeomycin + diphosphate + H2O => 3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite
REACT:R-MMU-375302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules (Mus musculus)
REACT:R-HSA-177922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR dimerization (Homo sapiens)
REACT:R-XTR-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Xenopus tropicalis)
RHEA:30309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + NADP(+) + xanthine => 7-methylxanthine + H(+) + NADPH + O2
GO:0004073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate-semialdehyde dehydrogenase"
GO:0004073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)
GO:0004073	skos:altLabel	"ASA dehydrogenase"
GO:0004073	skos:prefLabel	"aspartate-semialdehyde dehydrogenase"
GO:0004073	skos:altLabel	"L-aspartate-beta-semialdehyde dehydrogenase"
GO:0004073	skos:altLabel	"aspartic semialdehyde dehydrogenase"
GO:0004073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate semialdehyde dehydrogenase activity
GO:0004073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ASA dehydrogenase activity
GO:0004073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic semialdehyde dehydrogenase activity
GO:0004073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH
GO:0004073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic beta-semialdehyde dehydrogenase activity
GO:0004073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
GO:0004073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-semialdehyde dehydrogenase activity
GO:0004073	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate-beta-semialdehyde dehydrogenase activity
REACT:R-HSA-8961632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLA1 gene transcription is stimulated by E2F1 (Homo sapiens)
GO:0031852	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mu-type opioid receptor ligand
GO:0031852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	morphine receptor binding
GO:0031852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mu-type opioid receptor binding
REACT:R-HSA-9666458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)
RHEA:19742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + H2O => CoA + formate + H(+)
REACT:R-RNO-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Rattus norvegicus)
RHEA:70186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 alpha-isomaltosyl-(1->4)-D-maltotriose <=> alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose
RHEA:70665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(out) + H(+)(out) => 4-hydroxy-L-proline(in) + H(+)(in)
EC:2.7.11.13	skos:prefLabel	"protein kinase C"
EC:2.7.11.13	skos:altLabel	"calcium-independent protein kinase C"
EC:2.7.11.13	skos:altLabel	"calcium/phospholipid dependent protein kinase"
EC:2.7.11.13	skos:altLabel	"cPKC"
EC:2.7.11.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein kinase C"
EC:2.7.11.13	skos:altLabel	"nPKC"
EC:2.7.11.13	skos:altLabel	"calcium-dependent protein kinase C"
EC:2.7.11.13	skos:altLabel	"PKC"
RHEA:15274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-dopa => 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate
REACT:R-DME-209210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT92E is phosphorylated by phosphorylated HOP (Drosophila melanogaster)
RHEA:66926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(R)-3-hydroxyalkanoate](n+1) + CoA => [(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA
REACT:R-CFA-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Canis familiaris)
RHEA:64390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 4 A + sn-3-O-phytanylglycerol 1-phosphate
REACT:R-MMU-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Mus musculus)
REACT:R-SCE-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Saccharomyces cerevisiae)
REACT:R-BTA-9606887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CD19:VAV binds PI3K and GRB2 (Bos taurus)
REACT:R-XTR-416929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PGF2a (Xenopus tropicalis)
RHEA:30756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamate => ADP + carbamoyl phosphate
REACT:R-CEL-5694442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH2,3 bind GRIA1 (Caenorhabditis elegans)
REACT:R-DDI-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Dictyostelium discoideum)
REACT:R-DDI-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Dictyostelium discoideum)
RHEA:11608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA
RHEA:55381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3alpha-hydroxy bile acid CoA + NAD(+) => a 3-oxo bile acid CoA + H(+) + NADH
REACT:R-DRE-5624486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylates RAF1 on Y340,Y341 (Danio rerio)
RHEA:16594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine => 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:44601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP + H(+) => a fatty acyl-AMP + diphosphate
REACT:R-GGA-6791227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Gallus gallus)
REACT:R-CEL-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Caenorhabditis elegans)
RHEA:72337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate
RHEA:27590	skos:altLabel	"pantothenate synthetase"
RHEA:27590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + ADP + H(+) + phosphate
RHEA:27590	skos:prefLabel	"pantoate--beta-alanine ligase (ADP-forming)"
RHEA:27590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pantoate--beta-alanine ligase (ADP-forming)"
RHEA:27590	skos:altLabel	"pantoate--beta-alanine ligase"
GO:0102286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine N-delta-acetyltransferase activity
REACT:R-CFA-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Canis familiaris)
RHEA:69828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactaldehyde dehydrogenase activity
REACT:R-DRE-9620456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sGC stimulators bind sGC:NO (Danio rerio)
RHEA:71227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + selenocyanate(out) = 2 Na(+)(in) + selenocyanate(in)
REACT:R-CFA-6806974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET dimers autophosphorylate (Canis familiaris)
REACT:R-CFA-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Canis familiaris)
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxynitrilase activity
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetone-cyanohydrin acetone-lyase activity
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxynitrile lyase activity
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	2-hydroxyisobutyronitrile acetone-lyase activity
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetone-cyanohydrin acetone-lyase (cyanide-forming)
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-hydroxynitrile lyase activity
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming)
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	(S)-acetone-cyanohydrin lyase activity
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxynitrilase activity
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetone-cyanhydrin lyase activity
GO:0047606	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetone-cyanohydrin lyase activity
REACT:R-GGA-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
REACT:R-SSC-5695957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Sus scrofa)
REACT:R-SSC-1475028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Sus scrofa)
RHEA:36814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + GDP-alpha-D-perosamine <=> CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)
RHEA:15936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-propane-1,2-diol + NAD(+) <=> (S)-lactaldehyde + H(+) + NADH
RHEA:45919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:72166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) <=> chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)
RHEA:72190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + sucrose(out) <=> H(+)(in) + sucrose(in)
RHEA:13446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantetheine + H2O => (R)-pantothenate + cysteamine
REACT:R-CFA-6805103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates TP53 (Canis familiaris)
RHEA:28754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + ubiquinone-8 <=> dihydroxyacetone phosphate + ubiquinol-8
RHEA:39877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol
GO:0140758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal-dependent deNEDDylase activity
REACT:R-BTA-4615905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO1 (Bos taurus)
GO:0018662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenol 2-monooxygenase activity
GO:0018662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenol hydroxylase activity
GO:0018662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenol o-hydroxylase activity
GO:0018662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)
GO:0036470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TH activator activity
GO:0036470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine hydroxylase activator activity
GO:0036470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine 3-monooxygenase activator activity
REACT:R-BTA-8854612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)
RHEA:12287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methylglutarate + succinyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + succinate
REACT:R-HSA-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Homo sapiens)
REACT:R-CEL-442368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)
REACT:R-DDI-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Dictyostelium discoideum)
REACT:R-XTR-159567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform ST to ST-CoA (Xenopus tropicalis)
REACT:R-DRE-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Danio rerio)
RHEA:17115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine + phosphoethanolamine => H2O + L-serine-phosphoethanolamine
GO:0050180	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity
GO:0050180	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lactase-phlorizin hydrolase
GO:0050180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phloretin hydrolase activity
RHEA:46850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+)
REACT:R-XTR-9008692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds SMAD3 (Xenopus tropicalis)
RHEA:58619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-octanoyl-(2S)-hydroxyglycine <=> glyoxylate + octanamide
RHEA:35120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O => bisdemethoxycurcumin + CO2 + 2 CoA
REACT:R-GGA-1112510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6ST is tyrosine phosphorylated (Gallus gallus)
REACT:R-SSC-2559456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)
RHEA:29402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ITP <=> diphosphate + H(+) + IMP
RHEA:68767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine
RHEA:32464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + 2 S-adenosyl-L-methionine => 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine
REACT:R-BTA-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
REACT:R-BTA-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Bos taurus)
RHEA:28940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + xanthosine(in) => H(+)(out) + xanthosine(out)
REACT:R-DDI-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Dictyostelium discoideum)
RHEA:47063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-MMU-4755419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1H4 with SUMO1 (Mus musculus)
REACT:R-HSA-5684248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
REACT:R-HSA-202365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-BTA-5661123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate Me2K5-histone H3 (Bos taurus)
REACT:R-DRE-5229203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates histone H2A arginine-30 (H2AR29) (Danio rerio)
RHEA:25937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-methylquinoline + A + H2O => 8-methylquinolin-2(1H)-one + AH2
RHEA:25194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-methylcatechol + H(+) + NADH
GO:0102134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxy-campesterol C-23 hydroxylase activity
REACT:R-CEL-444773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-TM7 receptors bind chondroitin sulphate (Caenorhabditis elegans)
REACT:R-HSA-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Homo sapiens)
REACT:R-SSC-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Sus scrofa)
RHEA:15477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:15477	skos:prefLabel	"scymnol sulfotransferase"
RHEA:15477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scymnol sulfotransferase"
REACT:R-HSA-3928580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate EFNBs (Homo sapiens)
RHEA:64828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + acetyl-CoA = 3-hydroxy-benzyl acetate + CoA
REACT:R-MMU-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Mus musculus)
GO:0042030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosinetriphosphatase inhibitor
GO:0042030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase inhibitor activity
REACT:R-BTA-9714483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the ER membrane (Bos taurus)
REACT:R-RNO-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Rattus norvegicus)
REACT:R-XTR-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Xenopus tropicalis)
RHEA:52269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(aminomethyl)indole + S-adenosyl-L-methionine => (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine
RHEA:55600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphoceramide + GDP + H(+)
EC:3.2.1.43	skos:prefLabel	"beta-L-rhamnosidase"
EC:3.2.1.43	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-L-rhamnosidase"
RHEA:67052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + asnovolin J + O2 = A + asnovolin A + H2O
RHEA:51175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-2029475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of AA by iPLA2 upon FCGR activation (Mus musculus)
REACT:R-XTR-400509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Xenopus tropicalis)
RHEA:57886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Na(+)(out) + 2 phosphate => diphosphate + H2O + Na(+)(in)
REACT:R-CFA-4332235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds TGFBR2 (Canis familiaris)
RHEA:50398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O => (2-aminobenzoyl)acetate + H(+) + octanoyl-CoA
RHEA:49332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-2060328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS1 (Drosophila melanogaster)
REACT:R-BTA-200424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Bos taurus)
REACT:R-GGA-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Gallus gallus)
RHEA:62834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
GO:0062065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	box H/ACA snoRNP complex binding
RHEA:64018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose
RHEA:52940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-SSC-211929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C19 5-hydroxylates omeprazole (Sus scrofa)
RHEA:26251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + levopimaradienal + NADP(+) => H(+) + levopimaradienol + NADPH + O2
GO:0009673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity phosphate transmembrane transporter activity
GO:0009673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity phosphate transmembrane transporter activity
REACT:R-CFA-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Canis familiaris)
REACT:R-CFA-169905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS is phosphorylated by active TrkA receptor (Canis familiaris)
RHEA:47269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacterioruberin => H2O + monoanhydrobacterioruberin
REACT:R-DDI-70333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KHK dimer phosphorylates Fru to Fru 1-P (Dictyostelium discoideum)
RHEA:66484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxygypsogenate + UDP-alpha-D-glucose = 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP
REACT:R-CFA-936985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1 recruits TRAF6 (Canis familiaris)
GO:0035472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choriogonadotropin hormone receptor activity
GO:0035472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CG receptor activity
GO:0035472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorio-gonadotrophin receptor activity
GO:0035472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorionic gonadotropin hormone receptor
GO:0047853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity
GO:0047853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	difructose-anhydride synthase activity
GO:0047853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulobiose hydrolase activity
RHEA:44835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + tetradecanoyl-CoA <=> CoA + O-tetradecanoyl-(R)-carnitine
REACT:R-SPO-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)
REACT:R-CFA-8950423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Canis familiaris)
REACT:R-BTA-4546385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO2 (Bos taurus)
REACT:R-BTA-193452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Bos taurus)
REACT:R-RNO-2395364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP4 binds TGF-Beta-1 (Rattus norvegicus)
RHEA:42418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+) => a ubiquinone + L-proline
RHEA:22797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-hamamelose => ADP + D-hamamelose 2'-phosphate + H(+)
REACT:R-PFA-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Plasmodium falciparum)
REACT:R-SPO-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Schizosaccharomyces pombe)
RHEA:71884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide
REACT:R-DME-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Drosophila melanogaster)
REACT:R-SPO-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Schizosaccharomyces pombe)
REACT:R-DME-3222237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMYD2 methylates TP53 (Drosophila melanogaster)
REACT:R-SSC-374251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARC  is a non-specific receptor for many chemokines (Sus scrofa)
EC:3.4.23.21	skos:prefLabel	"rhizopuspepsin"
EC:3.4.23.21	skos:altLabel	"Rhizopus aspartic proteinase"
EC:3.4.23.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhizopuspepsin"
REACT:R-MMU-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Mus musculus)
RHEA:49221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP => CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate
REACT:R-HSA-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Homo sapiens)
RHEA:58312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-substituted-cholesteryl beta-D-glucoside + H2O = 25-substituted-cholesterol + D-glucose
REACT:R-PFA-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Plasmodium falciparum)
REACT:R-CEL-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Caenorhabditis elegans)
REACT:R-XTR-352107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Xenopus tropicalis)
REACT:R-DME-83788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to Type 2 promoter (Drosophila melanogaster)
REACT:R-CFA-3371385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α is cleaved by ADAM17 (TACE) (Canis familiaris)
RHEA:20851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O2 + phosphate + pyruvate <=> acetyl phosphate + CO2 + H2O2
REACT:R-HSA-5687095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 binds MIR34B and C gene (Homo sapiens)
RHEA:42440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NAD(+) = H(+) + iminosuccinate + NADH
RHEA:31915	skos:prefLabel	"maltokinase"
RHEA:31915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maltokinase"
RHEA:31915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)
REACT:R-DME-3225851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin and activate MAP3K5 (Drosophila melanogaster)
REACT:R-SSC-6801776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A binds bacterial phospholipids (Sus scrofa)
RHEA:54399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
RHEA:57001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + streptothricin F => CoA + H(+) + N(beta)-acetylstreptothricin F
RHEA:15327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate
RHEA:43990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+) => (2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2
RHEA:40802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + H2O <=> 2-methylpropanoate + CoA + H(+)
REACT:R-BTA-2161950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Bos taurus)
REACT:R-BTA-3777129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC3 containing complexes deacetylate histone (Bos taurus)
RHEA:68468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate
RHEA:55387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate <=> 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate
RHEA:30731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + FAD + H(+) = (2E)-butenoyl-CoA + FADH2
RHEA:38705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
REACT:R-MMU-8944257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIV (Mus musculus)
REACT:R-GGA-430135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds ADAP (Gallus gallus)
REACT:R-MMU-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Mus musculus)
REACT:R-RNO-8949649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Rattus norvegicus)
RHEA:47906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate => ATP + N-(acetyl)-sphing-4-enine
RHEA:55673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
REACT:R-DRE-4755411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates IKBKG with SUMO1 (Danio rerio)
RHEA:10491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate
REACT:R-BTA-163756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of fatty acid synthase (FAS) dimer (Bos taurus)
RHEA:63067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + tetraacetate lactone
RHEA:69572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + inosine = 2'-deoxyinosine + IMP
REACT:R-MMU-4615987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO2,3 (Mus musculus)
REACT:R-MMU-8938887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML binds RUNX1 (Mus musculus)
REACT:R-DRE-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Danio rerio)
REACT:R-MMU-919404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT5 is released (Mus musculus)
REACT:R-XTR-5229283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCNs bind lipids (Xenopus tropicalis)
RHEA:27331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyisourate + H2O + NAD(+) => H(+) + NADH + O2 + urate
GO:0102894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDPG:cyclo-DOPA 5-O-glucosyltransferase activity
REACT:R-SSC-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Sus scrofa)
GO:0005114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II transforming growth factor beta receptor binding
GO:0005114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGF-beta type II binding
GO:0005114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta ligand binding to type II receptor
GO:0005114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor beta receptor type II binding
GO:0005114	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	punt binding
GO:0005114	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	punt ligand
GO:0005114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II TGF-beta binding
REACT:R-RNO-417842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 receptor can bind to LPA (Rattus norvegicus)
RHEA:61181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucoside + UDP
REACT:R-DME-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Drosophila melanogaster)
REACT:R-BTA-2682349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Bos taurus)
REACT:R-XTR-9020259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Xenopus tropicalis)
GO:0052834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol monophosphatase activity
GO:0052834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-myo-inositol-phosphate phosphatase activity
GO:0052834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol-phosphate phosphohydrolase activity
GO:0052834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol phosphatase activity
GO:0052834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol monophosphate phosphatase activity
GO:0052834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol-phosphatase activity
GO:0052834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol-phosphate phosphatase activity
GO:0052834	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	myo-inositol-1(or 4)-phosphate phosphohydrolase activity
GO:0052834	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol-1(or 4)-monophosphatase activity
GO:0052834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol phosphatase activity
RHEA:15080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-[(R)-pantothenoyl]-L-cysteine <=> (R)-pantetheine + CO2
REACT:R-GGA-5654701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
REACT:R-CFA-156723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF20A (MKL2) by phosphorylation (Canis familiaris)
RHEA:15774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dihydroxyacetone => ADP + dihydroxyacetone phosphate + H(+)
RHEA:71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine in DNA + NAD(+) <=> an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide
REACT:R-RNO-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)
REACT:R-HSA-74736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Homo sapiens)
REACT:R-DRE-193766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
RHEA:22900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diacetyl reductase [(R)-acetoin forming]"
RHEA:22900	skos:prefLabel	"diacetyl reductase [(R)-acetoin forming]"
RHEA:22900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-acetoin + NAD(+) = diacetyl + H(+) + NADH
RHEA:22900	skos:altLabel	"(R)-acetoin dehydrogenase"
REACT:R-HSA-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Homo sapiens)
RHEA:23415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylputrescine <=> acetate + putrescine
GO:0061628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3-K27me3 modified histone binding
GO:0061628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3K27me3 modified histone binding
REACT:R-CFA-194311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Canis familiaris)
RHEA:72073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide => L-histidyl-[protein] + NAD(+)
REACT:R-XTR-8858428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FCAMR binds IgA (Xenopus tropicalis)
REACT:R-XTR-8868659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits auxilins to the clathrin-coated vesicle (Xenopus tropicalis)
RHEA:62273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine
RHEA:34855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + iminodiacetonitrile = N-(cyanomethyl)glycine + NH4(+)
REACT:R-BTA-983266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins bind microtubules (Bos taurus)
REACT:R-SCE-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)
RHEA:43884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + NAD(+) = 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH
REACT:R-CEL-167429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex  binds GTP (Caenorhabditis elegans)
REACT:R-GGA-159783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)
RHEA:52048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)
GO:0102197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vinylacetate caboxylester hydrolase activity
REACT:R-XTR-8848930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 translocates to the nucleus (Xenopus tropicalis)
RHEA:32971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine
RHEA:21326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + oxidized [rubredoxin] => 2 H(+) + reduced [rubredoxin] + superoxide
RHEA:49050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin] => 25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-HSA-8964492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DREAM complex binds the RBL1 gene promoter (Homo sapiens)
REACT:R-HSA-3788748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL6 promoter (Homo sapiens)
REACT:R-HSA-3560789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol (Homo sapiens)
RHEA:34924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(in) => nitrate(out)
RHEA:69540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + streptomycin = 6-O-guanylylstreptomycin + diphosphate
RHEA:28306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
RHEA:28306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase"
RHEA:28306	skos:prefLabel	"GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase"
RHEA:57195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] <=> glycolate + H(+) + L-lysyl-[protein]
REACT:R-HSA-9664871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 translocates from cytosol to perixosomal membrane (Homo sapiens)
REACT:R-GGA-352921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphosphoglycerate + NADH + H+ <=> glyceraldehyde 3-phosphate + NAD+ + phosphate (Gallus gallus)
GO:0047898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate:cytochrome b1 oxidoreductase activity
GO:0047898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate dehydrogenase (cytochrome) activity
GO:0047898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate:ferricytochrome-b1 oxidoreductase activity
RHEA:35381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA
REACT:R-XTR-174120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Xenopus tropicalis)
REACT:R-GGA-202721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 binds JAM3 (Gallus gallus)
RHEA:49339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dihydroxyspheroidene <=> H2O + spheroiden-2-one
REACT:R-RNO-5693153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1K dephosphorylates p-BCKDH (Rattus norvegicus)
REACT:R-HSA-168440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Homo sapiens)
RHEA:50140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O
REACT:R-HSA-211207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fragments of DFF45 dissociate from  DFF40 (Homo sapiens)
RHEA:70902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)
RHEA:55780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate = all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP
REACT:R-MMU-2029460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates LIMK1 (Mus musculus)
GO:0047207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity
GO:0047207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity
GO:0047207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructan:fructan fructosyl transferase activity
GO:0047207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-beta-D-fructan 1F-fructosyltransferase activity
GO:0047207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FFT activity
GO:0047207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-beta-fructan 1F-fructosyltransferase activity
GO:0047207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-beta-D-fructan 1(F)-fructosyltransferase activity
GO:0047207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity
GO:0047207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-beta-fructan 1(F)-fructosyltransferase activity
GO:0047207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,1-fructan:2,1-fructan 1-fructosyltransferase activity
RHEA:61901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + betaenone C => A + betaenone B
GO:0102804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oripavine 6-O-demethylase activity
REACT:R-RNO-75126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Rattus norvegicus)
REACT:R-DRE-1592240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NRF2 (Danio rerio)
RHEA:18549	skos:altLabel	"UDP-glucose--glycogen glucosyltransferase"
RHEA:18549	skos:prefLabel	"glycogen(starch) synthase"
RHEA:18549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycogen(starch) synthase"
RHEA:18549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP
RHEA:42216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA
REACT:R-CEL-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
REACT:R-DRE-2022411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)
RHEA:36478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA
RHEA:21837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinonate => 2-dehydro-3-deoxy-D-arabinonate + H2O
RHEA:39249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z)-eicosadienoyl-CoA + H2O => (3R)-hydroxy-(11Z)-eicosenoyl-CoA
REACT:R-SSC-1462023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-pro-defensins are cleaved to remove the signal peptide (Sus scrofa)
REACT:R-GGA-2243926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of histidino-hydroxylysinonorleucine cross-links (Gallus gallus)
RHEA:48399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine <=> 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-2530429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of soluble VTN:C5b-C9  (Canis familiaris)
REACT:R-SSC-9706287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to ABL2 (Sus scrofa)
GO:0034778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity
REACT:R-CEL-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)
REACT:R-MMU-9034539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates L-Ser (Mus musculus)
RHEA:41196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)
RHEA:24112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + O2 = glutathione disulfide + H2O2
RHEA:24112	skos:prefLabel	"glutathione oxidase"
RHEA:24112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione oxidase"
REACT:R-DRE-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Danio rerio)
RHEA:67566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + chenodeoxycholate
RHEA:55537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)
REACT:R-MMU-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Mus musculus)
REACT:R-MMU-71275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + glycine => ornithine + guanidoacetate (Mus musculus)
RHEA:28382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine = D-glucose 6-phosphate + L-lysine
REACT:R-DME-3640862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase binds AXIN (Drosophila melanogaster)
REACT:R-SSC-2730900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to pUb-TRAF6 (Sus scrofa)
REACT:R-GGA-5688834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds VCP (Gallus gallus)
GO:0102602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity
REACT:R-BTA-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Bos taurus)
REACT:R-HSA-446877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is K63 poly-ubiquitinated (Homo sapiens)
REACT:R-GGA-2395764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atREs binds to nascent CM (Gallus gallus)
RHEA:22714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide-GDP + diphosphate => adenosylcob(III)inamide phosphate + GTP + H(+)
REACT:R-GGA-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Gallus gallus)
REACT:R-SSC-109415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => adenosine + orthophosphate [NT5C1B] (Sus scrofa)
RHEA:62934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + cytidine + H(+) => H2O + N(4)-acetylcytidine
REACT:R-HSA-8932076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 (Homo sapiens)
REACT:R-GGA-2132100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fluid-phase proteolytic cleavage of factor B (Gallus gallus)
REACT:R-XTR-2424480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
RHEA:44378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out) => a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in)
GO:0016153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazolonepropionate hydrolase activity
GO:0016153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity
GO:0016153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urocanase activity
GO:0016153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)
GO:0016153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate hydratase activity
RHEA:14585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:56866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+) => 12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH
REACT:R-SSC-8864307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Sus scrofa)
REACT:R-HSA-5578883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)
RHEA:24486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + sulcatone => NAD(+) + sulcatol
RHEA:62331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2
REACT:R-BTA-2396399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillins bind BMPs (Bos taurus)
REACT:R-BTA-5610767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Bos taurus)
REACT:R-SSC-1236964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of peptide bound MHC class I complex to cell surface (Sus scrofa)
REACT:R-SSC-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Sus scrofa)
RHEA:53618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isoafricanol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-SSC-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Sus scrofa)
REACT:R-SCE-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Saccharomyces cerevisiae)
GO:0018561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
RHEA:27521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphing-4-enine 1-phosphate <=> phosphate + sphing-4-enine
REACT:R-SSC-2247511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2:ligand is endocytosed (Sus scrofa)
RHEA:19491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+) => dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide
GO:0018845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxychromene-2-carboxylate isomerase activity
RHEA:55079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + H(+) <=> 3-methylsulfanylpropanal + CO2
RHEA:22692	skos:prefLabel	"3-hydroxybenzoate 6-monooxygenase"
RHEA:22692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybenzoate 6-monooxygenase"
RHEA:22692	skos:altLabel	"3-hydroxybenzoate 6-hydroxylase"
RHEA:22692	skos:altLabel	"3-hydroxybenzoic acid-6-hydroxylase"
RHEA:22692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + H(+) + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD(+)
REACT:R-HSA-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
RHEA:13915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threonine => L-threonine
REACT:R-MMU-450984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Mus musculus)
RHEA:15089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + A = AH2 + pyruvate
RHEA:15089	skos:prefLabel	"D-lactate dehydrogenase (acceptor)"
RHEA:15089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-lactate dehydrogenase (acceptor)"
RHEA:55821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine
REACT:R-SSC-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Sus scrofa)
REACT:R-MMU-3214912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate MeK5-histone H3 (Mus musculus)
RHEA:37911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA
REACT:R-XTR-8853965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Xenopus tropicalis)
RHEA:54020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + propanoyl-CoA = CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]
RHEA:64167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-L-serine <=> formaldehyde + L-alanine
RHEA:59126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate => (S)-2,3-diaminopropanoate + ATP + citrate
REACT:R-DME-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
REACT:R-SSC-5668735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX3 complex (Sus scrofa)
REACT:R-BTA-8865320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX1 (Bos taurus)
REACT:R-MMU-1605768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Mus musculus)
RHEA:38142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
RHEA:24707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose => (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose
RHEA:43247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate
RHEA:11149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O
REACT:R-BTA-1433501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other adapter proteins with p-KIT (Bos taurus)
REACT:R-RNO-201637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plectin-1 (Rattus norvegicus)
RHEA:20635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lyso-ornithine lipid + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + L-ornithine
REACT:R-HSA-9031512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of APOE regulated by NR1H2 or NR1H3 (Homo sapiens)
RHEA:29651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine(in) + L-arginine(out) = agmatine(out) + L-arginine(in)
RHEA:55039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N,N-dimethylornithine lipid + S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine
GO:0003680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AT-rich DNA binding
GO:0003680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AT DNA binding
GO:0003680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	minor groove of adenine-thymine-rich DNA binding
GO:0003680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AT binding
RHEA:10323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O
REACT:R-BTA-205286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS interacts with p-KIT (Bos taurus)
RHEA:63543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin <=> L-leucine + neurotensin-(1-12)
REACT:R-DDI-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Dictyostelium discoideum)
REACT:R-HSA-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Homo sapiens)
REACT:R-CFA-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Canis familiaris)
REACT:R-DRE-8874206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L3 (Danio rerio)
RHEA:46575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-164696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chico is phosphorylated (Drosophila melanogaster)
RHEA:64924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + 2 H2O = dAMP + 2 H(+) + 2 phosphate
RHEA:54657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalool => (2E)-geraniol
RHEA:28199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH
RHEA:27961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + H2O <=> cytosine + D-ribose
REACT:R-HSA-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Homo sapiens)
REACT:R-CFA-5693346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CECRI deaminates Ade-Rib to Ino (Canis familiaris)
REACT:R-BTA-416639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Bos taurus)
GO:0047270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS glucosyltransferase II activity
GO:0047270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide glucosyltransferase II activity
GO:0047270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity
GO:0047270	skos:prefLabel	"lipopolysaccharide glucosyltransferase II"
GO:0047270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipopolysaccharide glucosyltransferase II"
GO:0047270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity
GO:0047270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity
RHEA:36815	skos:prefLabel	"dTDP-fucopyranose mutase"
RHEA:36815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-fucopyranose mutase"
RHEA:36815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-fucose = dTDP-alpha-D-fucofuranose
REACT:R-MMU-4084976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANS converts ManNAc-6-P to Neu5Ac-9-P (Mus musculus)
REACT:R-BTA-83677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4 deamination of cytidine (Bos taurus)
REACT:R-DDI-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Dictyostelium discoideum)
REACT:R-MMU-1295622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds CBL (Mus musculus)
REACT:R-SSC-9023627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Sus scrofa)
REACT:R-BTA-4341073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates PGR with SUMO1 (Bos taurus)
REACT:R-BTA-5649800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Bos taurus)
REACT:R-MMU-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Mus musculus)
RHEA:16529	skos:prefLabel	"sulfate adenylyltransferase (ADP)"
RHEA:16529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + sulfate = adenosine 5'-phosphosulfate + phosphate
RHEA:16529	skos:altLabel	"ADP-sulfurylase"
RHEA:16529	skos:altLabel	"adenosine diphosphate sulfurylase"
RHEA:16529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfate adenylyltransferase (ADP)"
RHEA:47467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-tetradecadienoyl-CoA <=> (2E,5Z)-tetradecadienoyl-CoA
RHEA:35391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA
REACT:R-XTR-159803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Xenopus tropicalis)
RHEA:63924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(4)-acetylcytidine = ADP + H(+) + N(4)-acetylcytidine 5'-phosphate
RHEA:10153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + NH4(+) => ADP + carbamoyl phosphate + H(+) + H2O
REACT:R-MMU-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Mus musculus)
REACT:R-CFA-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Canis familiaris)
RHEA:23350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2 => (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+)
RHEA:50025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine
REACT:R-GGA-606349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mis18 complex binds the centromere (Gallus gallus)
REACT:R-HSA-5662706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopachrome transforms to DHI (Homo sapiens)
REACT:R-CFA-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Canis familiaris)
REACT:R-HSA-196857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK2 phosphorylates PanK (Homo sapiens)
REACT:R-CFA-174122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Canis familiaris)
RHEA:35584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate => D-glyceraldehyde + pyruvate
REACT:R-RNO-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Rattus norvegicus)
REACT:R-XTR-9026911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Xenopus tropicalis)
REACT:R-DRE-2509793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses dIDP to dIMP (Danio rerio)
RHEA:41211	skos:prefLabel	"indole-3-acetate monooxygenase"
RHEA:41211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-acetate monooxygenase"
RHEA:41211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + H(+) + NADH + O2 = 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)
REACT:R-CFA-6806957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET receptor dimerizes (Canis familiaris)
REACT:R-SSC-72130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of an intermediate Spliceosomal C complex (Sus scrofa)
RHEA:11148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferroxidase"
RHEA:11148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O
RHEA:11148	skos:altLabel	"HEPH"
RHEA:11148	skos:altLabel	"ceruloplasmin"
RHEA:11148	skos:altLabel	"hephaestin"
RHEA:11148	skos:prefLabel	"ferroxidase"
RHEA:11375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + NH4(+) <=> AMP + diphosphate + H(+) + L-asparagine
RHEA:23503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) <=> 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
GO:0018493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formylmethanofuran dehydrogenase activity
GO:0018493	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylmethanofuran:acceptor oxidoreductase activity
GO:0018493	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylmethanofuran:(acceptor) oxidoreductase activity
REACT:R-GGA-193684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 recruits an atypical PKC (Gallus gallus)
REACT:R-BTA-3928601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 and PIP2 bind WASL, activating it (Bos taurus)
REACT:R-HSA-9033527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Homo sapiens)
RHEA:41928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]
RHEA:64713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + NADP(+) => H(+) + NADPH + propanal
RHEA:35456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 => (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)
RHEA:64073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O
REACT:R-CEL-399933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sema3A binds Nrp-1 bound to PlexinA (Caenorhabditis elegans)
RHEA:38217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-glucono-1,5-lactone + H(+) + NADH => D-glucose 6-phosphate + NAD(+)
REACT:R-DRE-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Danio rerio)
REACT:R-XTR-420580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:PVRL3 trans heterodimer formation (Xenopus tropicalis)
REACT:R-DME-6798317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Drosophila melanogaster)
RHEA:52377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)
RHEA:22806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH => (6S,9R)-vomifoliol + NAD(+)
RHEA:43672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-SSC-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Sus scrofa)
RHEA:57420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 oxidized [cytochrome P450] = H(+) + NAD(+) + 2 reduced [cytochrome P450]
GO:0015341	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	zinc efflux permease activity
GO:0015341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc efflux active transmembrane transporter activity
GO:0004845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UMP:pyrophosphate phosphoribosyltransferase activity
GO:0004845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridylate pyrophosphorylase activity
GO:0004845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine monophosphate pyrophosphorylase activity
GO:0004845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UMP pyrophosphorylase activity
GO:0004845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil phosphoribosyltransferase activity
GO:0004845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UPRTase activity
GO:0004845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UMP diphosphorylase activity
GO:0004845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridylic pyrophosphorylase activity
GO:0004845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine 5'-phosphate pyrophosphorylase activity
GO:0004845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UMP:diphosphate phospho-alpha-D-ribosyltransferase activity
REACT:R-RNO-1638845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERK phosphorylates CERA to form C1P (Rattus norvegicus)
RHEA:12472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine oxidase"
RHEA:12472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-ethylglycine + O2 = ethylamine + glyoxylate + H2O2
RHEA:12472	skos:prefLabel	"glycine oxidase"
GO:0033811	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity
GO:0033811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol-3-O-triglucoside O-coumaroyltransferase activity
RHEA:72112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) => L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)
REACT:R-DRE-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Danio rerio)
REACT:R-BTA-5649873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Bos taurus)
REACT:R-PFA-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Plasmodium falciparum)
RHEA:62419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + H2O <=> 4-hydroxybenzaldehyde + acetyl-CoA
RHEA:23566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 berberine + 2 H2O => 2 columbamine + O2
RHEA:42087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinal + H2O + NAD(+) <=> 9-cis-retinoate + 2 H(+) + NADH
REACT:R-BTA-6783177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates GATA3,IL33 (Bos taurus)
REACT:R-XTR-9638097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)
GO:0140394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled azole transmembrane transporter activity
GO:0140394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate
GO:0140394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type azole transporter activity
GO:0140394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	azole ABC transporter activity
RHEA:52435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate
REACT:R-HSA-4641236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)
REACT:R-MMU-210282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GPVI and FceRI gamma (Mus musculus)
RHEA:33537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + H(+) + lanosterol => H2O + lanosteryl ester
REACT:R-PFA-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Plasmodium falciparum)
RHEA:25454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + germacrene A => (2E,6E)-farnesyl diphosphate
REACT:R-DME-6793685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated TP53 translocates to the cytosol (Drosophila melanogaster)
REACT:R-MMU-5159250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF7IP binds SETDB1 (Mus musculus)
RHEA:50473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + H(+) + malonyl-CoA => (2-aminobenzoyl)acetyl-CoA + CO2 + CoA
REACT:R-CFA-5626982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF binds GNB2L1 (Canis familiaris)
RHEA:19063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + nitrate => H2O + NADP(+) + nitrite
EC:1.14.13.25	skos:altLabel	"methane hydroxylase"
EC:1.14.13.25	skos:prefLabel	"methane monooxygenase (soluble)"
EC:1.14.13.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methane monooxygenase (soluble)"
REACT:R-BTA-9724753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds anti-fibrinolytics (Bos taurus)
REACT:R-HSA-8848316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36 binds IL1RL2 (Homo sapiens)
RHEA:31333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-molybdopterin + diphosphate => ATP + H(+) + molybdopterin
REACT:R-RNO-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Rattus norvegicus)
REACT:R-CFA-4754181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me2K5-histone H3 (Canis familiaris)
RHEA:34675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + N,N-diacetyllegionaminate = CMP-N,N-diacetyllegionaminate + diphosphate
RHEA:34675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CMP-N,N'-diacetyllegionaminic acid synthase"
RHEA:34675	skos:prefLabel	"CMP-N,N'-diacetyllegionaminic acid synthase"
REACT:R-HSA-1458433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP14 (Homo sapiens)
REACT:R-HSA-8944223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type V (Homo sapiens)
REACT:R-RNO-1112666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)
RHEA:50853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
RHEA:71800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + H(+)(out) => Ca(2+)(out) + H(+)(in)
REACT:R-DME-199935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates CREB (Drosophila melanogaster)
EC:1.99.1.-	skos:prefLabel	"Hydroxylases"
EC:1.99.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hydroxylases"
RHEA:71147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhispidin + O2 = 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one
GO:0102142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity
GO:0140778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule stabilizing activity
REACT:R-DRE-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Danio rerio)
REACT:R-HSA-9018868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Homo sapiens)
RHEA:55496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-PFA-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Plasmodium falciparum)
RHEA:46617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]
REACT:R-XTR-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Xenopus tropicalis)
REACT:R-DDI-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Dictyostelium discoideum)
REACT:R-BTA-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Bos taurus)
REACT:R-MMU-378956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone is a heterodimer (Mus musculus)
RHEA:11280	skos:altLabel	"deoxycytidylate hydroxymethylase"
RHEA:11280	skos:prefLabel	"deoxycytidylate 5-hydroxymethyltransferase"
RHEA:11280	skos:altLabel	"dCMP hydroxymethylase"
RHEA:11280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxycytidylate 5-hydroxymethyltransferase"
RHEA:11280	skos:altLabel	"Deoxycytidylate hydroxymethyltransferase"
RHEA:11280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP
RHEA:58014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-hydroxy-diadenylate 2',3'-cylic phosphate => cyclic tetraadenylate
REACT:R-MMU-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Mus musculus)
RHEA:51956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylpropanal oxime = (Z)-2-methylpropanal oxime
REACT:R-MMU-379395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates 3MT to HVA (Mus musculus)
REACT:R-HSA-9659554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNQ4 transports K+ from the cytosol to the extracellular region (Homo sapiens)
REACT:R-CFA-5212679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3A binds Me2sR4-HIST1H4 (Canis familiaris)
REACT:R-HSA-9014454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG translocates to the ER membrane (Homo sapiens)
REACT:R-DME-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Drosophila melanogaster)
REACT:R-HSA-195251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the destruction complex (Homo sapiens)
REACT:R-HSA-9698931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C Nucleocapsid Assembly (Homo sapiens)
REACT:R-DME-209163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CI transports from the cytosol to the nucleus (Drosophila melanogaster)
RHEA:34896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + selenite(out) => ADP + H(+) + phosphate + selenite(in)
REACT:R-HSA-9736979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter (Homo sapiens)
GO:0004767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingomyelinase activity
GO:0004767	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphingomyelin cholinephosphohydrolase activity
GO:0004767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingomyelin phosphodiesterase activity
REACT:R-SCE-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Saccharomyces cerevisiae)
RHEA:64279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrysophanol-9-anthrone + O2 <=> chrysophanol + H2O
REACT:R-PFA-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Plasmodium falciparum)
RHEA:66932	skos:prefLabel	"hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase"
RHEA:66932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + 5-hydroxyanthranilate = avenanthramide C + CoA
RHEA:66932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate = avenanthramide A + CoA
RHEA:66932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase"
REACT:R-CFA-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Canis familiaris)
REACT:R-XTR-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Xenopus tropicalis)
REACT:R-MMU-2424252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds collagen, fibronectin, aggrecan and matrilins (Mus musculus)
REACT:R-GGA-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Gallus gallus)
REACT:R-SPO-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Schizosaccharomyces pombe)
REACT:R-RNO-2161951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Rattus norvegicus)
RHEA:56315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O <=> 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate
RHEA:11669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate
RHEA:64844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + benzoyl-CoA = (2E)-geranyl benzoate + CoA
REACT:R-HSA-3769397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOST binds LRP5/6 (Homo sapiens)
GO:0033792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity
GO:0033792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bile acid 7-dehydroxylase activity
GO:0033792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7alpha-dehydroxylase activity
GO:0033792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bile-acid 7alpha-dehydroxylase activity
GO:0033792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholate 7alpha-dehydroxylase activity
RHEA:43053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoate + ATP + CoA => 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate
REACT:R-GGA-204850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Dok-2 (Gallus gallus)
REACT:R-SSC-879910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 is phosphorylated, activated (Sus scrofa)
RHEA:54128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP
REACT:R-MMU-9733969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts dissociate from FABP6 (Mus musculus)
REACT:R-DRE-2730864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TRAF6 to CBM complex by binding to MALT1 (Danio rerio)
GO:1990827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deaminase binding
REACT:R-RNO-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Rattus norvegicus)
RHEA:39740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydodecanoate + H(+) + NADPH + O2 => 3,12-dihydroxydodecanoate + H2O + NADP(+)
RHEA:71105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(out) + S-methylmercury-L-cysteine(in) => L-methionine(in) + S-methylmercury-L-cysteine(out)
RHEA:33054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + NAD(+) <=> betaine aldehyde + H(+) + NADH
REACT:R-DRE-400143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fatty acid ligands activate PPARA (Danio rerio)
REACT:R-MMU-6804441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF34 or RFFL ubiquitinates phosphorylated TP53 (Mus musculus)
REACT:R-RNO-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Rattus norvegicus)
RHEA:23261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH
REACT:R-DME-5696197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Drosophila melanogaster)
REACT:R-RNO-2066299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 binds phosphorylated WWTR1 (TAZ) (Rattus norvegicus)
RHEA:47750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + n Na(+)(out) + NAD(+) => a ubiquinone + H(+) + n Na(+)(in) + NADH
RHEA:11430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone + H2O2 => beta-D-glucose + O2
REACT:R-BTA-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)
RHEA:25561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate => 9beta-pimara-7,15-diene + diphosphate
REACT:R-GGA-416562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGAP binds Plexin-B1 (Gallus gallus)
REACT:R-MMU-451634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Mus musculus)
RHEA:40789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + tetracosanoate => H2O + tetracosanoyl-CoA
RHEA:37339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O = (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)
REACT:R-HSA-1222723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric oxide is oxidized to nitrate (Homo sapiens)
REACT:R-HSA-6782881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe) (Homo sapiens)
RHEA:60907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 <=> 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
RHEA:48004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O
RHEA:72292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dimethylsuccinate(out) + 3 Na(+)(out) => 2,3-dimethylsuccinate(in) + 3 Na(+)(in)
REACT:R-SSC-6799196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Sus scrofa)
REACT:R-CEL-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
REACT:R-HSA-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)
RHEA:66243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + IC-asc-C9 <=> AMP + diphosphate + IC-asc-C9-CoA
REACT:R-XTR-2028629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Xenopus tropicalis)
REACT:R-HSA-5663120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds CRY1 gene (Homo sapiens)
REACT:R-BTA-5672972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
REACT:R-SPO-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Schizosaccharomyces pombe)
RHEA:52506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:48885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + H(+) + NADPH
RHEA:56474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2
RHEA:33565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine 1-phosphate + ADP + H(+) => (4R)-hydroxysphinganine + ATP
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dopamine monooxygenase activity
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-dopa oxidase activity
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol oxidase activity
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-DOPA monooxygenase activity
GO:0004097	skos:prefLabel	"catechol oxidase"
GO:0004097	skos:altLabel	"tyrosinase"
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyrocatechol oxidase
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	o-diphenol oxidoreductase
GO:0004097	skos:altLabel	"phenolase"
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tyrosinase activity
GO:0004097	skos:altLabel	"diphenol oxidase"
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catecholase
GO:0004097	skos:altLabel	"polyphenol oxidase"
GO:0004097	skos:altLabel	"o-diphenolase"
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphenol oxidase activity
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyphenol oxidase activity
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"catechol oxidase"
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phenolase activity
GO:0004097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	o-diphenolase activity
RHEA:14538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O => 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)
GO:0004083	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity
GO:0004083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisphosphoglycerate 2-phosphatase activity
REACT:R-BTA-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Bos taurus)
REACT:R-DME-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Drosophila melanogaster)
RHEA:72330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate <=> 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
RHEA:46478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-SCE-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Saccharomyces cerevisiae)
REACT:R-SSC-8853429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLDA1 binds AURKA (Sus scrofa)
REACT:R-SPO-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Schizosaccharomyces pombe)
REACT:R-DDI-168947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand binds to TLR10 (Dictyostelium discoideum)
RHEA:13306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + UDP-alpha-D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + UDP
REACT:R-SSC-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Sus scrofa)
RHEA:59039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:10529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-PFA-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Plasmodium falciparum)
REACT:R-XTR-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Xenopus tropicalis)
RHEA:60396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine
RHEA:68396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a percarboxylic acid + H2O = a carboxylate + H(+) + H2O2
GO:0080041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-ribose pyrophosphohydrolase activity
REACT:R-DME-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Drosophila melanogaster)
REACT:R-RNO-977071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Rattus norvegicus)
REACT:R-BTA-212252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Bos taurus)
REACT:R-HSA-9616116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2 and SOX10 bind the MAG gene (Homo sapiens)
RHEA:44088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + heptanoate = AMP + diphosphate + heptanoyl-CoA
REACT:R-BTA-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Bos taurus)
RHEA:13160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + CO2 + NADP(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH
REACT:R-RNO-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Rattus norvegicus)
RHEA:58424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + H(+) + NADPH
REACT:R-SCE-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Saccharomyces cerevisiae)
REACT:R-GGA-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Gallus gallus)
REACT:R-GGA-187035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-beta-NGF and mature beta-NGF are secreted (Gallus gallus)
REACT:R-HSA-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Homo sapiens)
REACT:R-MMU-1980125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH binds DTX (Mus musculus)
REACT:R-GGA-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Gallus gallus)
RHEA:10668	skos:prefLabel	"lysyltransferase"
RHEA:10668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysyltransferase"
RHEA:10668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)
REACT:R-RNO-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)
REACT:R-XTR-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Xenopus tropicalis)
REACT:R-HSA-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Homo sapiens)
REACT:R-CFA-1307955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds HS:KLB:FGF19 (Canis familiaris)
REACT:R-MMU-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Mus musculus)
RHEA:25030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-beta-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate
REACT:R-SSC-1183128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Sus scrofa)
REACT:R-BTA-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Bos taurus)
RHEA:63946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+) => a fatty acyl-CoA + sphinga-4E,14Z-dienine
REACT:R-HSA-8874204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3 (Homo sapiens)
RHEA:70468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 => a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate
RHEA:27908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + H(+) + NADPH => butanoyl-CoA + NADP(+)
RHEA:32925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-sn-glycerol)
RHEA:44715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + H2O <=> a 1-acylglycerol + a fatty acid + H(+)
REACT:R-MMU-622420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Mus musculus)
GO:0018764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-isopropylammelide isopropylaminohydrolase"
GO:0018764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-isopropylammelide = cyanurate + isopropylamine
GO:0018764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AtzC
GO:0018764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-isopropylammelide isopropylaminohydrolase activity
GO:0018764	skos:prefLabel	"N-isopropylammelide isopropylaminohydrolase"
REACT:R-HSA-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)
REACT:R-DME-73920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Drosophila melanogaster)
REACT:R-RNO-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Rattus norvegicus)
REACT:R-GGA-381135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)
REACT:R-HSA-9025007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1 (Homo sapiens)
REACT:R-MMU-444126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Mus musculus)
RHEA:57027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apulose 4-phosphate + D-glyceraldehyde 3-phosphate <=> D-xylulose 5-phosphate + dihydroxyacetone phosphate
REACT:R-HSA-9637605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PstS1 binds MRC1 (Homo sapiens)
RHEA:53530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-8858252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDLBP binds HDL (Xenopus tropicalis)
RHEA:18758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => CO2 + cylindrospermopsin + succinate
REACT:R-HSA-211350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)
REACT:R-HSA-140806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINC1 binds SERPINC1 activators (Homo sapiens)
REACT:R-DME-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Drosophila melanogaster)
REACT:R-MMU-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Mus musculus)
RHEA:58649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifamycin SV hemiaminal => H(+) + rifamycin SV ortho-naphthoquinone carboxamide
REACT:R-HSA-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Homo sapiens)
RHEA:58667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + a quinone <=> 2-oxoglutarate + a quinol
RHEA:43057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH => 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)
REACT:R-DRE-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Danio rerio)
RHEA:26223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Homo sapiens)
REACT:R-CEL-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Caenorhabditis elegans)
RHEA:35481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-5'-oxoaverantin + 2 H(+) + NADH => (1'S,5'R)-5'-hydroxyaverantin + NAD(+)
GO:0106166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane-spindle pole body anchor activity
GO:0106166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spindle pole body nuclear membrane anchor activity
GO:0106166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spindle pole body-nuclear membrane anchor activity
EC:3.4.24.25	skos:prefLabel	"vibriolysin"
EC:3.4.24.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vibriolysin"
EC:3.4.24.25	skos:altLabel	"aeromonolysin"
EC:3.4.24.25	skos:altLabel	"Aeromonas proteolytica neutral proteinase"
RHEA:16648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoyl-CoA <=> CoA + H(+) + hexadecanoate
REACT:R-BTA-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Bos taurus)
REACT:R-RNO-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Rattus norvegicus)
RHEA:33365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol 1-phosphate(in) + L-histidyl-[protein] => D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein]
REACT:R-DRE-199046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligands bind L-selectin (Danio rerio)
RHEA:24243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + AMP + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + AH2
RHEA:46638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + testosterone => 5beta-dihydrotestosterone + NADP(+)
RHEA:46989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2
RHEA:72193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-PFA-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Plasmodium falciparum)
REACT:R-SSC-6798528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Mn2+ (Sus scrofa)
RHEA:38855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:54046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-epi-alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:56057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein + UDP-alpha-D-glucose => genistein 7-O-beta-D-glucoside + H(+) + UDP
RHEA:26400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 O2 <=> 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde
REACT:R-HSA-8964634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Homo sapiens)
RHEA:46394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:28605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-977348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHGDH tetramer dehydrogenates 3PG (Homo sapiens)
RHEA:43188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2634) in 25S rRNA = H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine
RHEA:16447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein + H(+) + H2O => (2R,3S)-2,4',7-trihydroxyisoflavanone
GO:0052673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenol phosphotransferase activity
GO:0052673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenyl alcohol phosphotransferase activity
GO:0052673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenol kinase activity
GO:0052673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenyl alcohol kinase activity
RHEA:22547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
REACT:R-DRE-2032770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1 to the nucleus (Danio rerio)
RHEA:25203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabino-hex-3-ulose 6-phosphate => D-ribulose 5-phosphate + formaldehyde
RHEA:19560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + pregna-4,9(11)-diene-3,20-dione <=> 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O
REACT:R-XTR-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Xenopus tropicalis)
REACT:R-HSA-9670413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds to p-KIT mutants (Homo sapiens)
REACT:R-XTR-200682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial FPGS-1 transforms THF to THFPG (Xenopus tropicalis)
REACT:R-SSC-6814734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDSN binds the cornified envelope (Sus scrofa)
REACT:R-XTR-6806613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin tetramers bind to form unit length filaments (Xenopus tropicalis)
RHEA:47872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + H2O = ganglioside GA1 + N-acetylneuraminate
REACT:R-MMU-8944216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XV (Mus musculus)
REACT:R-GGA-8931653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Gallus gallus)
REACT:R-DME-6805640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates KAT6A (Drosophila melanogaster)
REACT:R-BTA-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Bos taurus)
RHEA:41909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-[ACP] => (2E)-hexadecenoyl-[ACP] + H2O
RHEA:24214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) => 5-(2-hydroxyethyl)-4-methylthiazole + ATP
GO:0051993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisic acid glucose ester beta-glucosidase activity
GO:0051993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABA-GE beta-glucosidase activity
RHEA:27650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + uridine = GDP + H(+) + UMP
REACT:R-SPO-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Schizosaccharomyces pombe)
RHEA:12281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
REACT:R-SPO-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Schizosaccharomyces pombe)
REACT:R-XTR-6792445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPH, I hydrolyse PA to 2-acyl LPA (Xenopus tropicalis)
REACT:R-HSA-418170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB1 binds MAPKs, SRC-1 (Homo sapiens)
REACT:R-DRE-5686587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates RAD52 (Danio rerio)
RHEA:47625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O
REACT:R-MMU-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Mus musculus)
RHEA:41984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propan-2-ol = acetone + H(+) + NADH
REACT:R-MMU-5654622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)
RHEA:49968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:64121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-serine + H2O => a fatty acid + L-serine
REACT:R-CFA-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Canis familiaris)
REACT:R-SPO-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Schizosaccharomyces pombe)
REACT:R-PFA-5229111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 transports APP from trans-Golgi network to endosome lumen (Plasmodium falciparum)
REACT:R-XTR-6793661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Xenopus tropicalis)
GO:0031420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkali metal ion binding
RHEA:24426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + L-ascorbate => 2 glutathione + L-dehydroascorbate
REACT:R-BTA-76434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of carbon tetrachloride to form a free radical (Bos taurus)
REACT:R-DME-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Drosophila melanogaster)
REACT:R-CFA-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Canis familiaris)
REACT:R-SSC-446894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binding leads to IRAK1:TRAF6 release (Sus scrofa)
RHEA:53785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-muricholate + deoxycholoyl-CoA => beta-muricholoyl-CoA + deoxycholate
REACT:R-CFA-9640254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Canis familiaris)
GO:0033998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulin fructotransferase (DFA-III-producing) activity
GO:0033998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity
GO:0033998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity
GO:0033998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulinase II activity
GO:0033998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulin fructotransferase (depolymerizing) activity
GO:0033998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulase II activity
GO:0033998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity
GO:0033998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inulin fructotransferase (DFA-III-forming) activity
GO:0033998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity
RHEA:21922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
REACT:R-XTR-374173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR1 (Xenopus tropicalis)
REACT:R-MMU-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Mus musculus)
GO:0015185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate transporter activity
GO:0015185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyrate transporter activity
GO:0015185	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	betaine/GABA:sodium symporter activity
GO:0015185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid transmembrane transporter activity
GO:0015185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA transporter activity
RHEA:16229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidate cytidylyltransferase"
RHEA:16229	skos:altLabel	"CDP-diglyceride synthetase"
RHEA:16229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate
RHEA:16229	skos:altLabel	"CDP-diglyceride pyrophosphorylase"
RHEA:16229	skos:altLabel	"CDP-diacylglycerol synthase"
RHEA:16229	skos:altLabel	"CDP-diglyceride diphosphorylase"
RHEA:16229	skos:prefLabel	"phosphatidate cytidylyltransferase"
REACT:R-MMU-5606996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds activated protein C (Mus musculus)
REACT:R-RNO-3928640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs phosphorylate MLC (Rattus norvegicus)
RHEA:24603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + sulfite <=> H2O2 + sulfate
REACT:R-DRE-8866941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MID1IP1 binds THRSP (Danio rerio)
RHEA:38984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)
REACT:R-SSC-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Sus scrofa)
RHEA:41210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
REACT:R-HSA-417898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y4 receptor can bind to UTP (Homo sapiens)
REACT:R-CFA-5251942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hikeshi binds HSP70s:ATP (Canis familiaris)
RHEA:20331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor] => ATP + L-seryl-[low-density-lipoprotein receptor]
REACT:R-BTA-2161620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by PTGDS (Bos taurus)
REACT:R-RNO-77613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR2 homodimer to dsRNA duplex (Rattus norvegicus)
REACT:R-GGA-163809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)
RHEA:53216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16501	skos:altLabel	"sn-glycero(3)phosphoinositol glycerophosphohydrolase"
RHEA:16501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-1D-myo-inositol = H(+) + myo-inositol + sn-glycerol 3-phosphate
RHEA:16501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerophosphoinositol glycerophosphodiesterase"
RHEA:16501	skos:altLabel	"sn-glycero-3-phospho-1-inositol glycerophosphohydrolase"
RHEA:16501	skos:prefLabel	"glycerophosphoinositol glycerophosphodiesterase"
EC:3.1.13.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exoribonuclease II"
EC:3.1.13.1	skos:altLabel	"ribonuclease II"
EC:3.1.13.1	skos:prefLabel	"exoribonuclease II"
REACT:R-DDI-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Dictyostelium discoideum)
REACT:R-DRE-6814695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PERP binds desmosomes (Danio rerio)
RHEA:12030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-carbamoyl-L-aspartate => H2O + L-5-carboxymethylhydantoin
REACT:R-SSC-429815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation Of Bloc-1 Complex (Sus scrofa)
RHEA:29798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + H2O(in) + Zn(2+)(out) <=> ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)
RHEA:64985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-9014434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GAPs stimulate RHOG GTPase activity (Bos taurus)
REACT:R-BTA-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Bos taurus)
REACT:R-CFA-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Canis familiaris)
RHEA:23570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-decenoyl-[ACP] => (2E)-decenoyl-[ACP]
RHEA:37997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate => all-trans-nonaprenyl diphosphate + H(+) + homogentisate
GO:1990760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	osmolarity-sensing cation channel activity
REACT:R-MMU-2243931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-lysinonorleucine cross-links (Mus musculus)
REACT:R-BTA-1793186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Bos taurus)
REACT:R-RNO-416683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA3E binds to PLXND1 (Rattus norvegicus)
REACT:R-HSA-3000137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Homo sapiens)
RHEA:39338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)
RHEA:69456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)
REACT:R-XTR-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Xenopus tropicalis)
RHEA:60727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + H2O + NADP(+) <=> dodecanoate + 2 H(+) + NADPH
REACT:R-SPO-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Schizosaccharomyces pombe)
REACT:R-BTA-8850326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds self-lipid-based antigen via CD1 (Bos taurus)
REACT:R-DRE-8865637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFSD2A transports LPC from extracellular region to plasma membrane (Danio rerio)
RHEA:53769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholate + allodeoxycholoyl-CoA => allocholoyl-CoA + allodeoxycholate
RHEA:32418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-isodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH
REACT:R-CFA-9011985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Canis familiaris)
GO:0050325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tauropine dehydrogenase activity
GO:0050325	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)
GO:0050325	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)
RHEA:15820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pyridoxamine 5'-phosphate <=> H2O2 + NH4(+) + pyridoxal 5'-phosphate
RHEA:68511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (Z)-beta-farnesene + diphosphate
REACT:R-HSA-8948524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTENP1 mRNA binds miR-19b RISC (Homo sapiens)
RHEA:10386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cyclopiazonate + diphosphate => cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate
RHEA:60784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A24 + O2 = CO2 + gibberellin A25 + H(+) + succinate
RHEA:45117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-ipsdienol + NADP(+) => H(+) + ipsdienone + NADPH
REACT:R-CEL-429767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Caenorhabditis elegans)
REACT:R-BTA-5632649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds GAS1 and PTCH (Bos taurus)
REACT:R-DME-211190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of DFF45 (117) (Drosophila melanogaster)
REACT:R-SSC-9638078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from keratan sulfate (Sus scrofa)
REACT:R-MMU-8855508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Mus musculus)
RHEA:60720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hept-2-enal + H2O + NADP(+) = (E)-hept-2-enoate + 2 H(+) + NADPH
GO:0003856	skos:altLabel	"dehydroquinate synthase"
GO:0003856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
GO:0003856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydroquinate synthase"
GO:0003856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate synthase activity
GO:0003856	skos:altLabel	"3-dehydroquinate synthetase"
GO:0003856	skos:altLabel	"5-dehydroquinate synthase"
GO:0003856	skos:altLabel	"5-dehydroquinic acid synthetase"
GO:0003856	skos:prefLabel	"3-dehydroquinate synthase"
RHEA:72462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + L-aspartate(out) <=> fumarate(out) + L-aspartate(in)
RHEA:34244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin guanine dinucleotide
RHEA:66441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-one + NADP(+) => but-3-en-2-one + H(+) + NADPH
REACT:R-DRE-9634834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACHEIs bind ACHE (Danio rerio)
REACT:R-CFA-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Canis familiaris)
REACT:R-DME-1678694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Drosophila melanogaster)
REACT:R-CEL-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Caenorhabditis elegans)
REACT:R-SSC-159826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Sus scrofa)
REACT:R-MMU-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Mus musculus)
REACT:R-BTA-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Bos taurus)
GO:0033921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	capsular-polysaccharide endo-1,3-alpha-galactosidase activity
GO:0033921	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polysaccharide depolymerase activity
GO:0033921	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	capsular polysaccharide galactohydrolase activity
GO:0033921	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aerobacter-capsular-polysaccharide galactohydrolase activity
GO:0008737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fuculose kinase activity
GO:0008737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuculokinase activity
GO:0008737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-fuculokinase (phosphorylating)
GO:0008737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:L-fuculose 1-phosphotransferase activity
REACT:R-XTR-8851038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 binds prenylated phosphoantigens (Xenopus tropicalis)
RHEA:18342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,4-lactone + H2O => D-xylonate + H(+)
RHEA:67562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate => 3'-phosphoadenylyl sulfate + taurocholate
REACT:R-HSA-5693549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Homo sapiens)
REACT:R-SCE-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Saccharomyces cerevisiae)
RHEA:33916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(methylamino)butanoate + H2O + O2 => H2O2 + methylamine + succinate semialdehyde
RHEA:33637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + docosanoyl-CoA => ATP + CoA + docosanoate
RHEA:55042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]
RHEA:15900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanoate + H2O <=> 4-aminobutanoate + acetate
REACT:R-GGA-8875374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds LRIG1 (Gallus gallus)
REACT:R-XTR-1855172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Xenopus tropicalis)
RHEA:37828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate
RHEA:24685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + NADP(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH
RHEA:45162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + CO2 => 3-oxopropanoate + H(+)
RHEA:68569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(5)-hydroxy-L-ornithine => (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O
RHEA:50798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin A2-S-(R)-glutathione => glutathione + prostaglandin A2
RHEA:36904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine
REACT:R-DDI-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Dictyostelium discoideum)
RHEA:31885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-amyrin => (S)-2,3-epoxysqualene
REACT:R-CEL-9654533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B recycles to the plasma membrane (Caenorhabditis elegans)
REACT:R-CFA-9724670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds imiquimod (Canis familiaris)
GO:0106370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-L-histidine N-pros-methyltransferase activity
GO:0106370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-SSC-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)
REACT:R-BTA-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Bos taurus)
REACT:R-HSA-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Homo sapiens)
REACT:R-GGA-5624952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the retrograde IFT train (Gallus gallus)
REACT:R-CEL-8934735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 arginine-methylates RUNX1 (Caenorhabditis elegans)
RHEA:16958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP + H2O => GMP + H(+)
REACT:R-RNO-5654659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)
REACT:R-HSA-389580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + H2O => formate + CoASH (Homo sapiens)
RHEA:37309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-asparagine => glycyl-L-asparagine + H2O
REACT:R-DME-9014641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Drosophila melanogaster)
REACT:R-XTR-9008577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37:IL18R1 binds SIGIRR (Xenopus tropicalis)
RHEA:61428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-trans-nepetalactol + NAD(+) = cis-trans-nepetalactone + H(+) + NADH
RHEA:37026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-RNO-6809015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Rattus norvegicus)
REACT:R-DDI-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Dictyostelium discoideum)
REACT:R-HSA-9031802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Maresins translocate from cytosol to extracellular region (Homo sapiens)
REACT:R-BTA-5687758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP4C:PPP4R2 dephosphorylates RPA2 (Bos taurus)
REACT:R-CFA-5621366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to p-Y65,Y76-FCER1G (Canis familiaris)
REACT:R-SSC-6784791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Sus scrofa)
REACT:R-CFA-193508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)
REACT:R-CFA-8855617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Canis familiaris)
REACT:R-RNO-975608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP2:atROL and FACYLs to atREs (Rattus norvegicus)
EC:3.4.21.36	skos:prefLabel	"pancreatic elastase"
EC:3.4.21.36	skos:altLabel	"pancreatopeptidase E"
EC:3.4.21.36	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pancreatic elastase"
EC:3.4.21.36	skos:altLabel	"pancreatic elastase I"
RHEA:24505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
RHEA:29321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phosphoethanolamine
RHEA:32771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate = 2,6-dioxo-6-phenylhexa-3-enoate
RHEA:63655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:68217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA
RHEA:34476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate => 15-cis-phytoene + 2 diphosphate
REACT:R-HSA-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Homo sapiens)
RHEA:34390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP
RHEA:12129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:21483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-furoyl-CoA + A + H2O <=> 5-hydroxy-2-furoyl-CoA + AH2 + H(+)
RHEA:56709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Sus scrofa)
RHEA:60165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine
RHEA:71247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-alanine(in) + chloride(in) + 2 Na(+)(in)
RHEA:35779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = mutildienyl diphosphate
REACT:R-CFA-2029467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)
REACT:R-XTR-3296326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR1 binds LACT (Xenopus tropicalis)
RHEA:39418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)
RHEA:59014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine
REACT:R-CFA-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Canis familiaris)
RHEA:13360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + NAD(+) <=> 3-oxopropanoate + H(+) + NADH
REACT:R-XTR-5633040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Xenopus tropicalis)
RHEA:36535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + sphinganine = CoA + H(+) + N-docosanoylsphinganine
REACT:R-CFA-5656158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ elongates POLI-incorporated dNMP (Canis familiaris)
RHEA:35568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine => (9Z,12Z)-octadecadienoate + ethanolamine
RHEA:60455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate <=> acetaldehyde + H(+) + sulfite
RHEA:31216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) => (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH
RHEA:16962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epsilon-(gamma-L-glutamyl)-L-lysine => 5-oxo-L-proline + L-lysine
REACT:R-HSA-375160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 binds to ATP (Homo sapiens)
REACT:R-HSA-983142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of peptide loading complex (PLC) (Homo sapiens)
REACT:R-SSC-5693542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RPA complexes with ssDNA at resected DNA DSBs (Sus scrofa)
REACT:R-CEL-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Caenorhabditis elegans)
REACT:R-DRE-9648114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 recruits NUDC to mitotic spindle (Danio rerio)
RHEA:13439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-cinnamoyl)-beta-D-glucose + UDP => (E)-cinnamate + UDP-alpha-D-glucose
REACT:R-RNO-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Rattus norvegicus)
REACT:R-BTA-2186607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Bos taurus)
RHEA:46949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + S-adenosyl-L-methionine => N(7)-methyl-GTP + S-adenosyl-L-homocysteine
RHEA:24220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ipsdienol synthase"
RHEA:24220	skos:altLabel	"CYP9T2"
RHEA:24220	skos:altLabel	"CYP9T3"
RHEA:24220	skos:altLabel	"myrcene hydroxylase"
RHEA:24220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] = (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24220	skos:prefLabel	"ipsdienol synthase"
RHEA:69516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-galactosamine + O2 = H2O2 + N-acetyl-D-galactosamino-1,5-lactone
REACT:R-XTR-5627275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOPC promotes translocation of CFTR to lysosomes (Xenopus tropicalis)
REACT:R-XTR-8942607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Xenopus tropicalis)
REACT:R-DME-2730870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
REACT:R-MMU-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Mus musculus)
REACT:R-DRE-508369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Danio rerio)
RHEA:34660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + S-adenosyl-L-methionine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
RHEA:62266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(in) + selenite(in) + Zn(2+)(in) => hydrogencarbonate(out) + selenite(out) + Zn(2+)(out)
RHEA:52054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-hydroxy-octadecanoate + H(+) + hexadecanoate => 9-hexadecanoyloxy-octadecanoate + H2O
REACT:R-CEL-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Caenorhabditis elegans)
REACT:R-RNO-4093327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHA binds TIAM1 (Rattus norvegicus)
REACT:R-MMU-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)
RHEA:27455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-iodo-L-tyrosine + NADPH => iodide + L-tyrosine + NADP(+)
REACT:R-DME-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-DME-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)
REACT:R-XTR-5686475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Xenopus tropicalis)
REACT:R-CEL-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Caenorhabditis elegans)
RHEA:31999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate
RHEA:31999	skos:prefLabel	"bicyclogermacrene synthase"
RHEA:31999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bicyclogermacrene synthase"
RHEA:11017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + H2O => (S)-ureidoglycolate + urea
RHEA:42854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine => 3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine
RHEA:13581	skos:prefLabel	"UDP-N-acetylglucosamine--lysosomal-enzyme N-acetylglucosaminephosphotransferase"
RHEA:13581	skos:altLabel	"N-acetylglucosaminylphosphotransferase"
RHEA:13581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP
RHEA:13581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine--lysosomal-enzyme N-acetylglucosaminephosphotransferase"
RHEA:16147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O => CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-BTA-9679029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds HCQ (Bos taurus)
GO:0015433	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled peptide antigen transmembrane transporter activity
GO:0015433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	major histocompatibility peptide transporter activity
GO:0015433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type peptide antigen transporter activity
GO:0015433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent peptide antigen transmembrane transporter activity
GO:0015433	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peptide antigen ABC transporter
GO:0015433	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	peptide antigen transporter activity
GO:0015433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide antigen-transporting ATPase activity
REACT:R-MMU-2076611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3STs sulfate GlcN at C3 in heparan sulfate (Mus musculus)
REACT:R-GGA-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
REACT:R-MMU-74711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRS (Mus musculus)
REACT:R-HSA-9614810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Latent HCMV Genome (Homo sapiens)
REACT:R-DRE-8849906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM1 binds NMDA receptor (Danio rerio)
REACT:R-HSA-5666197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds LIN7B (Homo sapiens)
REACT:R-MMU-190427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1b (Mus musculus)
REACT:R-SCE-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Saccharomyces cerevisiae)
GO:0005350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine transmembrane transporter activity
GO:0005350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine nucleobase transmembrane transporter activity
GO:0005350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine base transmembrane transporter activity
REACT:R-DME-174238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Drosophila melanogaster)
GO:0102678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity
RHEA:47337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diglucosyl-enterobactin + H(+) + UDP => monoglucosyl-enterobactin + UDP-alpha-D-glucose
REACT:R-RNO-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Rattus norvegicus)
REACT:R-RNO-5687121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPKAPK5 phosphorylates HSPB1 (Rattus norvegicus)
RHEA:23220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate
RHEA:23220	skos:prefLabel	"4-chlorobenzoate--CoA ligase"
RHEA:23220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-chlorobenzoate--CoA ligase"
REACT:R-SSC-3640861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 ubiquitinates ADP-ribosylated AXIN (Sus scrofa)
REACT:R-SPO-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Schizosaccharomyces pombe)
REACT:R-DME-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Drosophila melanogaster)
GO:0004690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic nucleotide-dependent protein kinase activity
RHEA:13951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 oxidized [rubredoxin] => H(+) + NADP(+) + 2 reduced [rubredoxin]
GO:0080014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thalianol hydroxylase activity
REACT:R-HSA-69144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)
REACT:R-GGA-2022383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)
RHEA:56917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH
REACT:R-SSC-5419281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRRF binds 55S ribosome:mRNA:tRNA (Sus scrofa)
EC:1.1.1.364	skos:prefLabel	"dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase"
EC:1.1.1.364	skos:altLabel	"dTDP-4-dehydro-6-deoxygulose reductase"
EC:1.1.1.364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase"
REACT:R-BTA-5654147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PLCG1 (Bos taurus)
RHEA:63218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + L-lysine
REACT:R-DRE-1861621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIA with IgG-coated Ag (Danio rerio)
RHEA:57416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-asparaginyl-[protein] = L-aspartyl-[protein] + NH4(+)
RHEA:47142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:45174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DME-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Drosophila melanogaster)
RHEA:23651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-beta-L-talose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH
RHEA:47741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate => CO2 + demethylphylloquinone + diphosphate
REACT:R-BTA-2066779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Bos taurus)
RHEA:42685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-hercynylcysteine S-oxide + H2O => L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide
RHEA:43552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate
REACT:R-HSA-9768930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds MDM2 gene promoter (Homo sapiens)
REACT:R-SSC-420582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin-1 trans heterodimer interaction (Sus scrofa)
RHEA:13118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)
GO:0008838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)
GO:0008838	skos:altLabel	"2,3-diaminopropanoate ammonia-lyase"
GO:0008838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha,beta-diaminopropionate ammonia-lyase activity
GO:0008838	skos:prefLabel	"diaminopropionate ammonia-lyase"
GO:0008838	skos:altLabel	"diaminopropionatase"
GO:0008838	skos:altLabel	"alpha,beta-diaminopropionate ammonia-lyase"
GO:0008838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diaminopropionate ammonia-lyase activity
GO:0008838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-diaminopropionate ammonia-lyase activity
GO:0008838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diaminopropionatase activity
GO:0008838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diaminopropionate ammonia-lyase"
REACT:R-PFA-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Plasmodium falciparum)
RHEA:48456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate
REACT:R-GGA-2168884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Methemoglobin to Hemopexin (Gallus gallus)
REACT:R-RNO-879907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate the receptor (Rattus norvegicus)
REACT:R-MMU-8987236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Mus musculus)
REACT:R-SSC-69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Sus scrofa)
REACT:R-XTR-114600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Xenopus tropicalis)
REACT:R-DRE-1433501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other adapter proteins with p-KIT (Danio rerio)
REACT:R-CEL-77590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CstF to the CPSF Bound Pre-mRNA (Caenorhabditis elegans)
RHEA:42628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42628	skos:prefLabel	"23S rRNA (uracil(747)-C(5))-methyltransferase"
RHEA:42628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (uracil(747)-C(5))-methyltransferase"
RHEA:47614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose
REACT:R-DME-8963915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D binds VDR (Drosophila melanogaster)
RHEA:72589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + AMP + diphosphate => (E)-sinapate + ATP + CoA
RHEA:61078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-echitovenine + CoA => (-)-minovincinine + acetyl-CoA
REACT:R-GGA-420582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin-1 trans heterodimer interaction (Gallus gallus)
RHEA:61912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out)
RHEA:25189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetate + H2O = chloride + glycolate + H(+)
RHEA:25189	skos:prefLabel	"haloacetate dehalogenase"
RHEA:25189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"haloacetate dehalogenase"
RHEA:16282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dihydrostreptomycin 6-phosphate => ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)
RHEA:16275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin + CMP + H(+) => an N-acylsphing-4-enine + CDP-choline
GO:0004980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melanocyte-stimulating hormone receptor activity
GO:0004980	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	MSH receptor activity
GO:0004980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melanocyte stimulating hormone receptor activity
GO:0004980	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	MSHR activity
GO:0004980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melanophore-stimulating hormone receptor activity
RHEA:48757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythritol + NAD(+) => D-erythrulose + H(+) + NADH
RHEA:44683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)
RHEA:41256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate
GO:0140585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	promoter-enhancer loop anchoring activity
GO:0140585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enhancer-promoter loop anchoring activity
REACT:R-SSC-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Sus scrofa)
REACT:R-CFA-6800299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGFAC cleaves pro-HGF to form HGF dimer (Canis familiaris)
REACT:R-HSA-3222006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STK11 (LKB1) phosphorylates NUAK1 (Homo sapiens)
RHEA:13455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate => 3'-phosphoadenylyl sulfate + quercetin
RHEA:40920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)
REACT:R-MMU-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Mus musculus)
RHEA:38886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP + CoA <=> a fatty acyl-CoA + AMP + diphosphate
REACT:R-MMU-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Mus musculus)
RHEA:38340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb1 + H2O => (20S)-ginsenoside Rd + D-glucose
REACT:R-SPO-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Schizosaccharomyces pombe)
RHEA:13291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP => a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-RNO-9025999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Rattus norvegicus)
REACT:R-SSC-2187355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters phosphorylated SMAD2/3 (Sus scrofa)
RHEA:45930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA => 15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA
REACT:R-HSA-6786567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine (Homo sapiens)
REACT:R-HSA-9768762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 gene transcription in non-neuronal cells is repressed by REST (Homo sapiens)
REACT:R-XTR-9014454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG translocates to the ER membrane (Xenopus tropicalis)
REACT:R-MMU-392054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)
RHEA:68563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate + D-glyceraldehyde 3-phosphate + NAD(+) <=> 1-arsono-3-phospho-D-glycerate + H(+) + NADH
GO:0005307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline:sodium symporter activity
GO:0005307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/choline symporter activity
REACT:R-DRE-9025957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Danio rerio)
REACT:R-HSA-5621367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4A binds HIV and HCV glycoproteins (Homo sapiens)
RHEA:15613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin
RHEA:15613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"precorrin-2 dehydrogenase"
RHEA:15613	skos:prefLabel	"precorrin-2 dehydrogenase"
RHEA:15613	skos:altLabel	"precorrin-2 oxidase"
REACT:R-MMU-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Mus musculus)
REACT:R-HSA-157124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds JAG2 (Homo sapiens)
REACT:R-BTA-176517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to PREG (Bos taurus)
REACT:R-SSC-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Sus scrofa)
REACT:R-CFA-8866283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)
EC:2.4.99.-	skos:prefLabel	"Transferring other glycosyl groups"
EC:2.4.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring other glycosyl groups"
RHEA:64552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] = 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Dictyostelium discoideum)
REACT:R-GGA-9696275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds GTP (Gallus gallus)
RHEA:14738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP => 3',5'-cyclic CMP + diphosphate
REACT:R-DME-190260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b binds to FGF (Drosophila melanogaster)
REACT:R-XTR-5362386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Hh (Xenopus tropicalis)
REACT:R-XTR-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Xenopus tropicalis)
REACT:R-HSA-210290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHIP (Homo sapiens)
REACT:R-SSC-183122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3b-bound Factor B (Sus scrofa)
REACT:R-RNO-163756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of fatty acid synthase (FAS) dimer (Rattus norvegicus)
RHEA:31635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc
REACT:R-HSA-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Homo sapiens)
RHEA:36820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA
REACT:R-HSA-1008240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 is a heterodimer (Homo sapiens)
RHEA:18825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose
RHEA:50253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H(+) + malonyl-CoA => a 3-oxoacyl-CoA + CO2 + CoA
RHEA:54270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2
REACT:R-SSC-209868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
REACT:R-HSA-5635859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU dissociates (Homo sapiens)
GO:0033969	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamyl-GABA hydrolase activity
GO:0033969	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PuuD
GO:0033969	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(glutamylamino)butanoate amidohydrolase activity
GO:0033969	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	YcjL
GO:0033969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
REACT:R-HSA-5601910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA (Homo sapiens)
REACT:R-RNO-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Rattus norvegicus)
REACT:R-CFA-199144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin 2 binds CD226 (Canis familiaris)
REACT:R-CEL-2197698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
REACT:R-CEL-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
RHEA:52511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-110251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of hypoxanthine by MPG glycosylase (Rattus norvegicus)
GO:0047065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)
GO:0047065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity
GO:0047065	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sulochrin oxidase activity
RHEA:42394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactono-1,5-lactone + H(+) + NADH => D-galactose + NAD(+)
REACT:R-XTR-5654615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:pFRS binds GRB2:SOS1 (Xenopus tropicalis)
RHEA:50168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine
REACT:R-GGA-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Gallus gallus)
REACT:R-GGA-205286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS interacts with p-KIT (Gallus gallus)
RHEA:60360	skos:prefLabel	"dehydro coenzyme F420 reductase"
RHEA:60360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dehydro coenzyme F420 reductase"
RHEA:60360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2
GO:0046403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA 3'-phosphatase activity
GO:0046403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polynucleotide 3'-phosphatase activity
GO:0046403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'(3')-polynucleotidase activity
GO:0046403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-polynucleotidekinase 3'-phosphatase activity
GO:0046403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide 3'-phosphohydrolase activity
GO:0046403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleate 3'-phosphatase activity
GO:0034848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity
RHEA:41878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-[ACP] + H2O => (3R)-hydroxydodecanoyl-[ACP]
REACT:R-MMU-428127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Mus musculus)
RHEA:22659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ethanolamine + L-serine <=> CMP + H(+) + L-serine-phosphoethanolamine
REACT:R-SSC-205238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 interacts with p-KIT (Sus scrofa)
REACT:R-PFA-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Plasmodium falciparum)
REACT:R-CEL-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Caenorhabditis elegans)
RHEA:50479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + L-cysteinyl-[PqsD protein] <=> CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]
REACT:R-DME-8934446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC phosphorylates SHC1 (Drosophila melanogaster)
REACT:R-MMU-5362551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Mus musculus)
REACT:R-DME-9727607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ binds sacubitrilat (Drosophila melanogaster)
RHEA:10851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an [alpha-factor](in) + ATP + H2O <=> ADP + an [alpha-factor](out) + H(+) + phosphate
EC:3.1.3.75	skos:prefLabel	"phosphoethanolamine/phosphocholine phosphatase"
EC:3.1.3.75	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoethanolamine/phosphocholine phosphatase"
EC:3.1.3.75	skos:altLabel	"3X11A"
EC:3.1.3.75	skos:altLabel	"PHOSPHO1"
REACT:R-MMU-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Mus musculus)
REACT:R-SSC-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Sus scrofa)
RHEA:68793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-NAD(+) + H2O => ADP-D-ribose + H(+) + nicotinamide
RHEA:12407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + UDP-alpha-D-galactose <=> H(+) + lactose + UDP
RHEA:35744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + versicolorin B => 2 H2O + NADP(+) + versicolorin A
RHEA:24531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactaldehyde + NAD(+) <=> H(+) + methylglyoxal + NADH
RHEA:57228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-GDP
REACT:R-SSC-1222491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoferrin scavenges iron ions (Sus scrofa)
REACT:R-BTA-4085133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUM (lumican) binds integrin alpha2beta1 (Bos taurus)
REACT:R-RNO-8938829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Rattus norvegicus)
REACT:R-BTA-194311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Bos taurus)
REACT:R-HSA-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Homo sapiens)
REACT:R-CFA-2129375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin cross-linking by lysyl oxidase (Canis familiaris)
REACT:R-DME-429694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 dissociates from the endoplasmic reticulum (Drosophila melanogaster)
REACT:R-SSC-5610732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI3 (Sus scrofa)
RHEA:28073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O + heme b <=> diphosphate + Fe(II)-heme o
REACT:R-PFA-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Plasmodium falciparum)
REACT:R-RNO-6807875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Rattus norvegicus)
RHEA:65096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA
GO:0050100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylitaconate D-isomerase activity
GO:0050100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylitaconate isomerase activity
GO:0050100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylitaconate delta-isomerase activity
GO:0050100	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylitaconate delta2-delta3-isomerase activity
REACT:R-RNO-6807055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR7 reduces 7-dehydroCHOL to CHOL (Rattus norvegicus)
REACT:R-RNO-174203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-mediated degradation of Emi1 (Rattus norvegicus)
REACT:R-BTA-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Bos taurus)
REACT:R-CEL-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)
REACT:R-DME-5654697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
RHEA:64598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+) => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose
RHEA:50709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
REACT:R-XTR-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Xenopus tropicalis)
RHEA:51862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-geranylumbelliferone + diphosphate => (2E)-geranyl diphosphate + umbelliferone
RHEA:52854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin]
RHEA:32643	skos:prefLabel	"lupanine 17-hydroxylase (cytochrome c)"
RHEA:32643	skos:altLabel	"lupanine dehydrogenase (cytochrome c)"
RHEA:32643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + lupanine = 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)
RHEA:32643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lupanine 17-hydroxylase (cytochrome c)"
RHEA:56313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O => 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate
RHEA:52442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose
RHEA:14083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + indole => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate
REACT:R-HSA-9626046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-GFAP binds EEF1A1 (Homo sapiens)
REACT:R-HSA-9034053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Homo sapiens)
GO:0005183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GnRH activity
GO:0005183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gonadotropin hormone-releasing hormone activity
GO:0005183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gonadotrophin hormone-releasing hormone activity
GO:0005183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteinizing hormone-releasing hormone activity
GO:0005183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteinizing hormone/follicle-stimulating hormone releasing factor activity
GO:0005183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LH/FSH-RF
GO:0005183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHRH activity
GO:0005183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteinizing hormone-releasing factor activity
REACT:R-HSA-9682712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp15 binds RB1 (Homo sapiens)
RHEA:63609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apelin-17 + H2O => apelin-16 + L-phenylalanine
RHEA:27917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate
REACT:R-DME-2731074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Drosophila melanogaster)
GO:0034575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-isopropylaniline dehydrogenase activity
REACT:R-SPO-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Schizosaccharomyces pombe)
REACT:R-HSA-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Homo sapiens)
REACT:R-GGA-8944263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type II (Gallus gallus)
RHEA:54548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 1,5-bisphosphate + H2O = D-xylulose 5-phosphate + phosphate
REACT:R-HSA-9725332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYC/MYCN bind the ALK gene (Homo sapiens)
RHEA:36289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theobromine
GO:0008469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine N-methylase activity
GO:0008469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone arginine N-methyltransferase activity
GO:0008469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine N-methyltransferase activity
GO:0008469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity
GO:0008469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity
RHEA:16414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]
REACT:R-BTA-3215406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds WDR77 (Bos taurus)
RHEA:37320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-methionine(out) + H2O => ADP + glycyl-L-methionine(in) + H(+) + phosphate
REACT:R-SSC-383363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 2 (NK2) binds to nuerokinin A (Sus scrofa)
REACT:R-MMU-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Mus musculus)
RHEA:37643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-DME-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Drosophila melanogaster)
REACT:R-XTR-181450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Xenopus tropicalis)
REACT:R-SCE-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Saccharomyces cerevisiae)
REACT:R-DRE-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Danio rerio)
RHEA:41734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-alpha-D-glucosyl](n) + phosphate
GO:0033426	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine tRNA
GO:0033426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAC codon-amino acid adaptor activity
REACT:R-GGA-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Gallus gallus)
REACT:R-BTA-380076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 1 (NK1) binds to substance P (Bos taurus)
REACT:R-DRE-8986985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Danio rerio)
RHEA:44864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)
REACT:R-DRE-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Danio rerio)
RHEA:41299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine
RHEA:19192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate <=> (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2
RHEA:57769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrotoluene + NADH + O2 => 3-methylcatechol + NAD(+) + nitrite
EC:1.14.14.-	skos:prefLabel	"With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"
EC:1.14.14.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"
REACT:R-RNO-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Rattus norvegicus)
EC:4.2.2.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chondroitin B lyase"
EC:4.2.2.19	skos:altLabel	"chondroitinase B"
EC:4.2.2.19	skos:altLabel	"ChonB"
EC:4.2.2.19	skos:prefLabel	"chondroitin B lyase"
REACT:R-SSC-1602399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLB1 (Sus scrofa)
REACT:R-SSC-379415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Sus scrofa)
REACT:R-SSC-2454192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Allergen dependent IgE bound FCERI aggregation (Sus scrofa)
REACT:R-GGA-381503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP6 binds IGF forming IGF:IGFBP6 (Gallus gallus)
REACT:R-CEL-508308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Caenorhabditis elegans)
REACT:R-MMU-174452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha on the C-strand of the telomere (Mus musculus)
REACT:R-HSA-9756574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 S binds SFTPD 12mer (Homo sapiens)
REACT:R-MMU-9634850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT (Mus musculus)
GO:0010420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
GO:0010420	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyprenyldihydroxybenzoate methyltransferase activity
GO:0010420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
RHEA:45366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoate + (4R)-hydroxysphinganine => H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine
GO:0047505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)
GO:0047505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	l-menthol monooxygenase activity
GO:0047505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol monooxygenase activity
REACT:R-RNO-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Rattus norvegicus)
GO:0008390	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2D11
GO:0008390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone 16-alpha-hydroxylase activity
GO:0008390	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2D10
GO:0008390	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2B10
GO:0008390	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2B9
GO:0008390	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2D9
REACT:R-SSC-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Sus scrofa)
REACT:R-SPO-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)
RHEA:12378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-fuculose 1-phosphate => ATP + L-fuculose
REACT:R-HSA-5591052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROCR binds Protein C (Homo sapiens)
REACT:R-DRE-9701507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN6 dephosphorylates JAK3 (Danio rerio)
REACT:R-XTR-5368596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Xenopus tropicalis)
RHEA:58727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine
RHEA:33733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine
REACT:R-XTR-5138432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 is phosphorylated by PKC (Xenopus tropicalis)
REACT:R-CEL-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Caenorhabditis elegans)
REACT:R-BTA-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Bos taurus)
RHEA:18830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + NAD(+) => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH
REACT:R-HSA-1250380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Homo sapiens)
GO:0004198	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calpain activity
GO:0004198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent cysteine-type endopeptidase activity
REACT:R-XTR-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Xenopus tropicalis)
REACT:R-SSC-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Sus scrofa)
REACT:R-CFA-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)
RHEA:42839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH <=> 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)
RHEA:54297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-tyrosyl-[protein] => diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]
RHEA:34368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylamide + H2O => acrylate + NH4(+)
RHEA:62966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose
RHEA:34204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => aureusidin 6-O-beta-glucoside + H2O
REACT:R-BTA-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Bos taurus)
RHEA:37979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine = 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine
RHEA:20579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminohydroquinone => 3-hydroxyaminophenol
RHEA:68205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoylglycerol + octadecanoyl-CoA => 1,2-dihexanoyl-3-octadecanoylglycerol + CoA
RHEA:17803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-L-phenylalanine => acetyl-CoA + L-phenylalanine
REACT:R-GGA-2730892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV to p-SLP-76 (Gallus gallus)
REACT:R-SSC-1592240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NRF2 (Sus scrofa)
REACT:R-SCE-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)
REACT:R-BTA-5672083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KTN1 binds Kinesin-1 (Bos taurus)
REACT:R-HSA-374665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with SIAH1 (Homo sapiens)
REACT:R-XTR-4615905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO1 (Xenopus tropicalis)
GO:0106323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-limonene 1,2-monooxygenase NADPH activity
GO:0106323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)
REACT:R-MMU-159567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform ST to ST-CoA (Mus musculus)
REACT:R-SPO-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Schizosaccharomyces pombe)
RHEA:27537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphate
GO:0015571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine transmembrane transporter activity
GO:0015571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine permease activity
REACT:R-DRE-174786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Danio rerio)
EC:3.4.23.46	skos:altLabel	"beta-site APP-cleaving enzyme 1"
EC:3.4.23.46	skos:altLabel	"beta-secretase"
EC:3.4.23.46	skos:prefLabel	"memapsin 2"
EC:3.4.23.46	skos:altLabel	"BACE1"
EC:3.4.23.46	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"memapsin 2"
EC:3.4.23.46	skos:altLabel	"membrane-associated aspartic protease 2"
EC:3.4.23.46	skos:altLabel	"beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1"
REACT:R-BTA-9614273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGRG heterodimer translocates to plasma membrane (Bos taurus)
REACT:R-RNO-2090037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(6) (Rattus norvegicus)
REACT:R-RNO-446877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is K63 poly-ubiquitinated (Rattus norvegicus)
REACT:R-XTR-168933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of phosphorylated IRF3/IRF7 (Xenopus tropicalis)
RHEA:36542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexadecanoylsphinganine
RHEA:50360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile + O2 = benzoyl cyanide + H2O2
RHEA:50360	skos:prefLabel	"(R)-mandelonitrile oxidase"
RHEA:50360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-mandelonitrile oxidase"
GO:0102013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled L-glutamate tranmembrane transporter activity
GO:0102013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate-importing ATPase activity
REACT:R-SSC-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Sus scrofa)
RHEA:72178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) <=> 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)
REACT:R-MMU-159762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)
REACT:R-CEL-176517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to PREG (Caenorhabditis elegans)
RHEA:23059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea <=> cyanamide + H2O
RHEA:37924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 => (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate
RHEA:19542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + L-glutamyl 5-phosphate + NADPH
RHEA:21856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA
RHEA:21856	skos:prefLabel	"cyclohexa-1,5-dienecarbonyl-CoA hydratase"
RHEA:21856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexa-1,5-dienecarbonyl-CoA hydratase"
RHEA:21856	skos:altLabel	"cyclohexa-1,5-diene-1-carboxyl-CoA hydratase"
RHEA:21856	skos:altLabel	"dienoyl-CoA hydratase"
RHEA:21856	skos:altLabel	"cyclohexa-1,5-diene-1-carbonyl-CoA hydratase"
RHEA:65415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP(in) + NAD(+)(out) <=> dAMP(out) + NAD(+)(in)
GO:0030280	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	structural constituent of epidermis
GO:0030280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of skin epidermis
RHEA:58784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 = a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate
REACT:R-XTR-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)
REACT:R-XTR-266089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Discoidal HDL binds membrane-associated free cholesterol (Xenopus tropicalis)
GO:0102081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homotaurine:2-oxoglutarate aminotransferase activity
RHEA:71263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-proline(out) + 2 Na(+)(out) = chloride(in) + L-proline(in) + 2 Na(+)(in)
REACT:R-SSC-205328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other tyrosine kinases with p-KIT (Sus scrofa)
RHEA:59149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + marinolate C => AMP + diphosphate + marinoloyl-CoA C
RHEA:46101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => cortisol + H2O + 2 oxidized [adrenodoxin]
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-4-hydroxyglutarate aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-oxoglutarate glyoxylate-lyase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-4-hydroxyglutaric aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-4-hydroxyglutaric aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxoglutarate aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-ketoglutarate aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DL-4-hydroxy-2-ketoglutarate aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyketoglutarate aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-4-hydroxybutyrate aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyketoglutaric aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KHG-aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-ketoglutaric aldolase activity
GO:0008700	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-4-hydroxyglutarate aldolase activity
REACT:R-CFA-6805276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates TP53 (Canis familiaris)
RHEA:48701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol
RHEA:70307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine
REACT:R-MMU-1169192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B dephosphorylates GHR (Mus musculus)
RHEA:58405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + NADP(+) => H(+) + hexanal + NADPH
REACT:R-BTA-392202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 12:Gi complex (Bos taurus)
RHEA:62269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-3-methylbutyrate + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH
REACT:R-SSC-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Sus scrofa)
RHEA:62303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)
RHEA:49130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine => AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine
REACT:R-SSC-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Sus scrofa)
REACT:R-CFA-2465934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL translocates from Muller cells to cone photoreceptor cells (Canis familiaris)
REACT:R-MMU-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Mus musculus)
RHEA:20075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + glycine => D-allothreonine
RHEA:12544	skos:prefLabel	"hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)"
RHEA:12544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate
RHEA:12544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)"
RHEA:45246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA
REACT:R-BTA-451418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates IRAK1 (Bos taurus)
RHEA:25985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0140344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triglyceride transfer activity
GO:0140344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triglyceride carrier activity
REACT:R-CFA-2025890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds NFATC1,2,3 (Canis familiaris)
GO:0038047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mu-opioid receptor activity
GO:0038047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	morphine receptor activity
REACT:R-XTR-9731393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA, EDNRB bind non-selective ERAs (Xenopus tropicalis)
REACT:R-DDI-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)
REACT:R-DDI-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)
RHEA:38302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA
RHEA:31672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:68729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:47230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein] => docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-DME-157849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes containing mRNA that does not circularize (Drosophila melanogaster)
RHEA:10672	skos:altLabel	"DNA photolyase"
RHEA:10672	skos:prefLabel	"deoxyribodipyrimidine photo-lyase"
RHEA:10672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyribodipyrimidine photo-lyase"
RHEA:10672	skos:altLabel	"photoreactivating enzyme"
RHEA:10672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclobutadithymidine in DNA = a thymidine dimer in DNA
REACT:R-HSA-2424476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV2/3 (Homo sapiens)
GO:0102665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-glutamate synthetase activity
REACT:R-GGA-5336182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37 binds prosaptide (Gallus gallus)
REACT:R-GGA-167429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex  binds GTP (Gallus gallus)
REACT:R-MMU-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Mus musculus)
REACT:R-SCE-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)
RHEA:46780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:46780	skos:prefLabel	"sn-1 linoleoyl-lipid 6-desaturase"
RHEA:46780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sn-1 linoleoyl-lipid 6-desaturase"
RHEA:36190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
GO:0018827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity
GO:0018827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDMS dehydrochlorinase activity
REACT:R-HSA-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Homo sapiens)
REACT:R-MMU-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Mus musculus)
RHEA:67333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinal + H2O + NAD(+) => 13-cis-retinoate + 2 H(+) + NADH
RHEA:48070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)) + H2O
REACT:R-CFA-2872498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Canis familiaris)
RHEA:22225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA => 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O
REACT:R-BTA-5577237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNH2:KCNE transport K+ from cytosol to extracellular region (Bos taurus)
REACT:R-CFA-2395314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysino-5-ketonorleucine cross-links (Canis familiaris)
REACT:R-BTA-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
RHEA:18775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein]
GO:0038062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	discoidin domain receptor
GO:0038062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine kinase collagen receptor activity
GO:0038062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	collagen RTK activity
REACT:R-CFA-8940134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 binds FOLA (Canis familiaris)
RHEA:34091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-phosphooxy-L-lysine phospho-lyase"
RHEA:34091	skos:altLabel	"5-phosphohydroxy-L-lysine ammoniophospholyase"
RHEA:34091	skos:prefLabel	"5-phosphooxy-L-lysine phospho-lyase"
RHEA:34091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate
REACT:R-DRE-429571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Danio rerio)
REACT:R-DME-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Drosophila melanogaster)
REACT:R-CEL-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Caenorhabditis elegans)
RHEA:47078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+) => 17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH
RHEA:64696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl alcohol + NAD(+) = benzaldehyde + H(+) + NADH
RHEA:70629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+)
REACT:R-DRE-429449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk activation leads to SLP-76 activation (Danio rerio)
REACT:R-HSA-9694476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)
RHEA:36386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl adenylate + tobramycin <=> AMP + H(+) + nebramycin 5'
RHEA:54336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-HSA-83660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-anchored TNF-α binds TNFR1 (Homo sapiens)
REACT:R-DME-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)
GO:0035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine/adenine mispair binding
GO:0035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A/A mispair binding
RHEA:18221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkylacetylglycerophosphatase"
RHEA:18221	skos:prefLabel	"alkylacetylglycerophosphatase"
RHEA:18221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate
RHEA:23128	skos:altLabel	"4-hydroxybutyrate--CoA ligase"
RHEA:23128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + AMP + diphosphate
RHEA:23128	skos:altLabel	"4-hydroxybutyrate-CoA synthetase"
RHEA:23128	skos:prefLabel	"4-hydroxybutyrate--CoA ligase (AMP-forming)"
RHEA:23128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybutyrate--CoA ligase (AMP-forming)"
REACT:R-BTA-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Bos taurus)
REACT:R-RNO-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Rattus norvegicus)
REACT:R-CFA-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Canis familiaris)
RHEA:34936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + H(+) => diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate
RHEA:29358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + H2O <=> 2'-deoxyuridine + phosphate
RHEA:20634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + L-ornithine => a lyso-ornithine lipid + H(+) + holo-[ACP]
GO:0015364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dicarboxylate:inorganic phosphate antiporter activity
REACT:R-RNO-904830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
REACT:R-RNO-8876319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC50A1 transports Glc from cytosol to extracellular region (Rattus norvegicus)
REACT:R-CEL-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Caenorhabditis elegans)
REACT:R-CFA-8954082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds the PRC1 complex (Canis familiaris)
RHEA:50697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-9014467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the ER membrane (Canis familiaris)
REACT:R-DRE-5661121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Danio rerio)
RHEA:33145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol(out) => galactitol(in)
REACT:R-RNO-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Rattus norvegicus)
RHEA:32567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-camphene synthase"
RHEA:32567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (1R,4S)-camphene + diphosphate
RHEA:32567	skos:prefLabel	"(+)-camphene synthase"
REACT:R-DME-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Drosophila melanogaster)
REACT:R-SSC-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Sus scrofa)
RHEA:38781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:57473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + UDP-alpha-D-glucose => 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP
RHEA:16044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-beta-D-glucosyl](n) + phosphate <=> [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
GO:0102936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenate-UDP-glucosyltransferase activity
REACT:R-MMU-9611839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β3-agonists bind ADRB3 (Mus musculus)
REACT:R-SCE-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Saccharomyces cerevisiae)
REACT:R-BTA-2993763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Bos taurus)
REACT:R-HSA-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Homo sapiens)
RHEA:18413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactosylceramide beta-1,3-galactosyltransferase"
RHEA:18413	skos:prefLabel	"lactosylceramide beta-1,3-galactosyltransferase"
RHEA:18413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:19922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 5-phosphate + NADP(+) => D-ribulose 5-phosphate + H(+) + NADPH
REACT:R-HSA-352119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Homo sapiens)
REACT:R-CEL-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Caenorhabditis elegans)
RHEA:23308	skos:prefLabel	"glucarate O-hydroxycinnamoyltransferase"
RHEA:23308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + D-glucarate = 2-O-[(E)-sinapoyl]-D-glucarate + CoA
RHEA:23308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucarate O-hydroxycinnamoyltransferase"
REACT:R-DME-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Drosophila melanogaster)
REACT:R-HSA-444527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR is a receptor for formyl peptides (Homo sapiens)
RHEA:62003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + protoporphyrinogen IX <=> 3 AH2 + protoporphyrin IX
REACT:R-BTA-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)
REACT:R-RNO-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Rattus norvegicus)
REACT:R-CEL-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Caenorhabditis elegans)
REACT:R-CFA-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Canis familiaris)
REACT:R-CEL-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)
REACT:R-DME-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Drosophila melanogaster)
GO:0047249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sarsapogenin 3-beta-glucosyltransferase activity
GO:0047249	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity
GO:0047249	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-sarsapogenin glucosyltransferase activity
GO:0047249	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity
GO:0047249	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sarsapogenin 3beta-glucosyltransferase activity
REACT:R-DRE-9667965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds PP2A (Danio rerio)
RHEA:28979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + nitrite(in) = H(+)(in) + nitrite(out)
RHEA:56918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-androstan-17-one + NADP(+)
RHEA:22437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate
RHEA:21556	skos:prefLabel	"calmodulin-lysine N-methyltransferase"
RHEA:21556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"calmodulin-lysine N-methyltransferase"
RHEA:21556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine
RHEA:67136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + ADP + phosphate
RHEA:28059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lyxopyranose => L-xylulose
RHEA:36103	skos:prefLabel	"anthranilate O-methyltransferase"
RHEA:36103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthranilate O-methyltransferase"
RHEA:36103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + S-adenosyl-L-methionine = O-methyl anthranilate + S-adenosyl-L-homocysteine
RHEA:54330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + holo-[ACP] + 2 NADP(+) => 2 H(+) + hexadecanoyl-[ACP] + 2 NADPH
GO:0050481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
GO:0050481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mandelic acid 4-hydroxylase activity
GO:0050481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mandelate 4-monooxygenase activity
GO:0050481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-mandelate 4-hydroxylase activity
REACT:R-BTA-5687653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Bos taurus)
REACT:R-BTA-8948222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)
REACT:R-HSA-2162225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from small HA fragments (Homo sapiens)
RHEA:56272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome cL] + H2O + methanol = 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)
REACT:R-DRE-996755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFPM proteins bind GATA proteins (Danio rerio)
REACT:R-RNO-8938231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds CREBBP (Rattus norvegicus)
REACT:R-HSA-1791163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Endoplasmin) (Homo sapiens)
REACT:R-GGA-9038163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Gallus gallus)
RHEA:62277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine => 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine
EC:4.8.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hydro-lyases"
EC:4.8.1.-	skos:prefLabel	"Hydro-lyases"
RHEA:61735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviol + UDP-alpha-D-glucose <=> H(+) + steviolmonoside + UDP
GO:0036220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITP diphosphatase activity
GO:0036220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine-5'-triphosphate pyrophosphohydrolase activity
GO:0036220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITP pyrophosphatase activity
REACT:R-XTR-111746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Xenopus tropicalis)
RHEA:23268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + H2O = glycine + urea
RHEA:23268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanidinoacetase"
RHEA:23268	skos:altLabel	"glycocyaminase"
RHEA:23268	skos:prefLabel	"guanidinoacetase"
REACT:R-CFA-199046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligands bind L-selectin (Canis familiaris)
REACT:R-BTA-9611839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β3-agonists bind ADRB3 (Bos taurus)
REACT:R-DDI-9024872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 17(S)-Hp-DHA to PDX (Dictyostelium discoideum)
REACT:R-HSA-8950583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
RHEA:37584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine + H2O + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)
REACT:R-RNO-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Rattus norvegicus)
REACT:R-CEL-165758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and inactivation of eEF2K by activated S6K1 (Caenorhabditis elegans)
REACT:R-RNO-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Rattus norvegicus)
GO:0106054	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA-specific 2-thiouridylase
GO:0106054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA U34 sulfurtransferase activity
GO:0106054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA U34 2-thiouridylase
GO:0106054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA U34 thiol-transferase activity
REACT:R-SSC-8865637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFSD2A transports LPC from extracellular region to plasma membrane (Sus scrofa)
REACT:R-GGA-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Gallus gallus)
RHEA:55228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-195734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuraminidase (NA) synthesis (Homo sapiens)
RHEA:21699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
REACT:R-CFA-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Canis familiaris)
REACT:R-GGA-879222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP:NLRP1 binds ATP (Gallus gallus)
REACT:R-RNO-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Rattus norvegicus)
RHEA:25210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
REACT:R-BTA-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Bos taurus)
RHEA:49774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexacosanoylglycine => glycine + hexacosanoyl-CoA
GO:0080047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-L-galactose phosphorylase activity
GO:0080047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose-1-phosphate guanylyltransferase (GDP) activity
GO:0080047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP:galactose-1-phosphate guanyltransferase activity
GO:0051861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolipid binding
REACT:R-DRE-9707186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 binds ALOX5 inhibitors (Danio rerio)
REACT:R-CEL-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Caenorhabditis elegans)
REACT:R-RNO-158959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Rattus norvegicus)
REACT:R-RNO-912527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
REACT:R-DRE-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Danio rerio)
GO:0005104	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fibroblast growth factor
GO:0005104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR binding
GO:0005104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibroblast growth factor receptor binding
GO:0005104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGF receptor binding
GO:0005104	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FGFR ligand
GO:0005104	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fibroblast growth factor receptor ligand
REACT:R-DME-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Drosophila melanogaster)
REACT:R-CFA-372519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcCho is hydrolyzed to Cho and acetate by ACHE (Canis familiaris)
REACT:R-XTR-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Xenopus tropicalis)
REACT:R-DRE-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)
REACT:R-BTA-975594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLB1 hydrolyses RPALM to atROL (Bos taurus)
RHEA:54082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine => 5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine
RHEA:47338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoate + H(+) + NADPH <=> AMP + butanal + diphosphate + NADP(+)
RHEA:54385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-5alpha-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH
REACT:R-CFA-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Canis familiaris)
REACT:R-XTR-5632652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds CDON and PTCH (Xenopus tropicalis)
RHEA:69706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O <=> beta-D-galactose + N-hexadecanoylsphing-4-enine
REACT:R-DRE-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)
REACT:R-DRE-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Danio rerio)
REACT:R-DDI-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Dictyostelium discoideum)
REACT:R-HSA-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Homo sapiens)
REACT:R-HSA-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
REACT:R-CFA-73920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Canis familiaris)
RHEA:25503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> diphosphate + terpinolene
GO:0031409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pigment binding
EC:3.4.24.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"matrilysin"
EC:3.4.24.23	skos:altLabel	"putative (or punctuated) metalloproteinase-1"
EC:3.4.24.23	skos:altLabel	"uterine metalloendopeptidase"
EC:3.4.24.23	skos:altLabel	"PUMP-1"
EC:3.4.24.23	skos:altLabel	"matrin"
EC:3.4.24.23	skos:altLabel	"matrix metalloproteinase 7"
EC:3.4.24.23	skos:prefLabel	"matrilysin"
RHEA:59253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate => (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA
REACT:R-CFA-5654734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Canis familiaris)
REACT:R-SSC-159101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Sus scrofa)
REACT:R-SSC-6793685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated TP53 translocates to the cytosol (Sus scrofa)
RHEA:37520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Homo sapiens)
REACT:R-BTA-209903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline is converted to adrenaline (Bos taurus)
REACT:R-RNO-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Rattus norvegicus)
RHEA:25950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+) => a 1,2-diacyl-sn-glycerol + CTP
GO:0018607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-indanone monooxygenase activity
REACT:R-CFA-379048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
REACT:R-XTR-1855171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Xenopus tropicalis)
RHEA:16525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxygalactonokinase"
RHEA:16525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-galactonate + ATP = 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)
RHEA:16525	skos:altLabel	"2-oxo-3-deoxygalactonate kinase"
RHEA:16525	skos:altLabel	"2-keto-3-deoxy-galactonokinase"
RHEA:16525	skos:prefLabel	"2-dehydro-3-deoxygalactonokinase"
REACT:R-HSA-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Homo sapiens)
RHEA:61199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
RHEA:52619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)
RHEA:65980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hnu + previtamin D3 = tachysterol 3
REACT:R-XTR-4420099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHB  (Xenopus tropicalis)
RHEA:23629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)
RHEA:22114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine
RHEA:51252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 = (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
RHEA:67590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+) => a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O
RHEA:22884	skos:altLabel	"MGAT"
RHEA:22884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine
RHEA:22884	skos:prefLabel	"methionine--glyoxylate transaminase"
RHEA:22884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionine--glyoxylate transaminase"
RHEA:55405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + UTP => [phosphate](n+1) + UDP
REACT:R-CEL-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Caenorhabditis elegans)
REACT:R-GGA-2028644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Gallus gallus)
REACT:R-BTA-417825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y11 receptor can bind to ATP (Bos taurus)
REACT:R-CEL-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Caenorhabditis elegans)
RHEA:55305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
REACT:R-DDI-390329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)
REACT:R-RNO-374298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid receptors bind opioid peptides (Rattus norvegicus)
REACT:R-MMU-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Mus musculus)
RHEA:23445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + NAD(+) => H(+) + NADH + pyruvate
RHEA:30957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,7',9,9'-tetra-cis-lycopene + 2 a quinol => 9,9'-di-cis-zeta-carotene + 2 a quinone
RHEA:29370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H2O <=> cytidine + phosphate
REACT:R-DRE-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Danio rerio)
RHEA:35973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + fumitremorgin B => 12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate
RHEA:67357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA => (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA
REACT:R-BTA-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Bos taurus)
REACT:R-HSA-167085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:HIV-1 early elongation complex (Homo sapiens)
RHEA:18044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-139918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BIM by JNK (Bos taurus)
RHEA:22800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloeucalenol = obtusifoliol
RHEA:22800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cycloeucalenol cycloisomerase"
RHEA:22800	skos:prefLabel	"cycloeucalenol cycloisomerase"
RHEA:22800	skos:altLabel	"cycloeucalenol--obtusifoliol isomerase"
RHEA:36350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine <=> 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine
REACT:R-SSC-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Sus scrofa)
REACT:R-CFA-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Canis familiaris)
RHEA:67775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O <=> a 5'-end dephospho-ribonucleoside-RNA + phosphate
RHEA:33762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-fatty acyl-CoA + H(+) + NADPH <=> a 3-hydroxy-fatty acyl-CoA + NADP(+)
REACT:R-GGA-189398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
REACT:R-DDI-5662692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is oxidized to dopaquinone by TYR (Dictyostelium discoideum)
REACT:R-MMU-5624949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the anterograde IFT train (Mus musculus)
RHEA:24175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-5beta-steroid <=> a 3-oxo-Delta(4)-steroid + AH2
REACT:R-DME-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Drosophila melanogaster)
REACT:R-MMU-6784791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Mus musculus)
REACT:R-GGA-9750016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Gallus gallus)
REACT:R-CFA-3928640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs phosphorylate MLC (Canis familiaris)
RHEA:31989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baruol => (S)-2,3-epoxysqualene
REACT:R-HSA-2534160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) degradation by MMP13, CTSS (Homo sapiens)
REACT:R-SSC-204871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb2 (Sus scrofa)
RHEA:50234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]
REACT:R-MMU-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Mus musculus)
RHEA:66889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:15445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carbamoyl-serine ammonia-lyase"
RHEA:15445	skos:altLabel	"O-carbamoyl-L-serine deaminase"
RHEA:15445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + O-carbamoyl-L-serine = CO2 + 2 NH4(+) + pyruvate
RHEA:15445	skos:prefLabel	"carbamoyl-serine ammonia-lyase"
REACT:R-CFA-3134800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING dimerization (Canis familiaris)
RHEA:24871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-alpha-D-ribose 1-phosphate + adenine => 5'-deoxyadenosine + phosphate
RHEA:36085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycerol + H(+) + phosphocholine => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O
REACT:R-DDI-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Dictyostelium discoideum)
RHEA:17886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde => acetylene + H2O
REACT:R-DRE-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Danio rerio)
REACT:R-CFA-69140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap (Canis familiaris)
REACT:R-RNO-9757688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDN (Rattus norvegicus)
REACT:R-XTR-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)
REACT:R-HSA-1676162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Homo sapiens)
RHEA:17332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S,4R)-borneol + NAD(+) <=> (1R,4R)-camphor + H(+) + NADH
REACT:R-MMU-199131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR binds CD226 (Mus musculus)
REACT:R-CEL-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Caenorhabditis elegans)
REACT:R-DME-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Drosophila melanogaster)
REACT:R-RNO-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Rattus norvegicus)
REACT:R-MMU-8944246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXI (Mus musculus)
RHEA:27970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotriose + H2O = alpha-D-glucose + D-maltose
REACT:R-CFA-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Canis familiaris)
REACT:R-DRE-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Danio rerio)
RHEA:68602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropane-1-sulfonate + H2O => (2S)-3-sulfopropanediol
REACT:R-XTR-9691566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 binds nicorandil (Xenopus tropicalis)
REACT:R-RNO-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Rattus norvegicus)
RHEA:19831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + H2O2 => a primary alcohol + O2
REACT:R-XTR-5686578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates ABL1 (Xenopus tropicalis)
REACT:R-RNO-8983371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Rattus norvegicus)
RHEA:59737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + tetradecanoyl-CoA => CoA + S-tetradecanoyl-L-cysteinyl-[protein]
REACT:R-DME-6807106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN undergoes monoubiquitination (Drosophila melanogaster)
RHEA:21198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine
RHEA:23276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde
RHEA:23276	skos:altLabel	"2-dehydropantoate formaldehyde-lyase"
RHEA:23276	skos:altLabel	"ketopantoaldolase"
RHEA:23276	skos:prefLabel	"2-dehydropantoate aldolase"
RHEA:23276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydropantoate aldolase"
RHEA:58144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)
RHEA:53187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-BTA-2997709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO1 (Bos taurus)
REACT:R-DME-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Drosophila melanogaster)
RHEA:27830	skos:prefLabel	"beta-phellandrene synthase (neryl-diphosphate-cyclizing)"
RHEA:27830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-phellandrene synthase (neryl-diphosphate-cyclizing)"
RHEA:27830	skos:altLabel	"phellandrene synthase 1"
RHEA:27830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neryl diphosphate = beta-phellandrene + diphosphate
RHEA:23361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP
RHEA:24200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + H(+) = aniline + CO2
RHEA:39538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O
RHEA:44741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-O-demethylrifamycin SV + S-adenosyl-L-methionine => H(+) + rifamycin SV + S-adenosyl-L-homocysteine
REACT:R-MMU-5620914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF4:GTP binds VxPx-motifs of membrane proteins (Mus musculus)
REACT:R-SSC-947535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Sus scrofa)
GO:2001066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amylopectin binding
REACT:R-DME-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Drosophila melanogaster)
RHEA:54006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O
REACT:R-XTR-5649723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Xenopus tropicalis)
RHEA:25815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermidine + O2 <=> 3-acetamidopropanal + H2O2 + putrescine
RHEA:10290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-rhamnonate => H2O + L-rhamnono-1,4-lactone
REACT:R-DRE-9008696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) translocates from the cytosol to the nucleus (Danio rerio)
REACT:R-MMU-176250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR-ATRIP to the RPA-ssDNA complex (Mus musculus)
RHEA:53147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
GO:0047231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity
GO:0047231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-pyridoxine glucosyltransferase activity
GO:0047231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity
GO:0047231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity
GO:0047231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity
GO:0047231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine 5'-O-beta-D-glucosyltransferase activity
RHEA:15229	skos:prefLabel	"mannose-1-phosphate guanylyltransferase"
RHEA:15229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannose-1-phosphate guanylyltransferase"
RHEA:15229	skos:altLabel	"GTP-mannose-1-phosphate guanylyltransferase"
RHEA:15229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose
RHEA:15229	skos:altLabel	"GDP-mannose pyrophosphorylase"
REACT:R-RNO-176517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to PREG (Rattus norvegicus)
REACT:R-DME-5654406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)
RHEA:17820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
GO:0034922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-dihydroxypyrene dioxygenase activity
RHEA:41603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
RHEA:23650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-6-deoxy-beta-L-talose + NADP(+)
REACT:R-MMU-5603114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)
RHEA:70463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate
REACT:R-HSA-9698925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Packaging of Viral Genome Into C Capsids (Homo sapiens)
RHEA:47408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O = (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA
REACT:R-MMU-201423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI complexes with the Smad complex, suppressing BMP2 signalling (Mus musculus)
RHEA:27372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin + CoA + NAD(+) <=> acetaldehyde + acetyl-CoA + H(+) + NADH
REACT:R-SSC-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Sus scrofa)
RHEA:17058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]
RHEA:67445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-hydroxy-long-chain-fatty acyl-CoA => a long-chain fatty aldehyde + formyl-CoA
REACT:R-PFA-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Plasmodium falciparum)
RHEA:42901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(745) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:32473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-71275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + glycine => ornithine + guanidoacetate (Xenopus tropicalis)
REACT:R-CFA-9650858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Meglitinides bind ABCC8 (Canis familiaris)
REACT:R-BTA-9679421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCD1 binds PDCD1 inhibitors (Bos taurus)
REACT:R-GGA-5672969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF (Gallus gallus)
RHEA:13123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoshikimate + ADP + H(+) => ATP + shikimate
GO:0050006	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalulose synthase activity
GO:0050006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltulose synthase activity
GO:0050006	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose alpha-glucosyltransferase activity
GO:0050006	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isomaltulose synthetase activity
GO:0050006	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose glucosylmutase activity
REACT:R-RNO-9724670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds imiquimod (Rattus norvegicus)
REACT:R-CFA-5658430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF1 is degraded by the proteasome (Canis familiaris)
REACT:R-MMU-9709831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds TBK1 and IRF3 (Mus musculus)
REACT:R-SSC-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Sus scrofa)
REACT:R-DRE-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Danio rerio)
REACT:R-HSA-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
REACT:R-SCE-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-SSC-8854466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds RELN (Sus scrofa)
RHEA:46215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine <=> 4-amino-5-aminomethyl-2-methylpyrimidine + formate
REACT:R-MMU-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)
REACT:R-HSA-5627072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds GOPC:CFTR (Homo sapiens)
REACT:R-DME-8956676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TP73 (Drosophila melanogaster)
REACT:R-DRE-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Danio rerio)
REACT:R-BTA-1592436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP9 by MMPs (Bos taurus)
REACT:R-SSC-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Sus scrofa)
RHEA:60043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate <=> (2E)-3-methylhex-2-enoate + L-glutamine
RHEA:56039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)
REACT:R-HSA-5632646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 bind PTCH1 (Homo sapiens)
REACT:R-DDI-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Dictyostelium discoideum)
REACT:R-BTA-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Bos taurus)
RHEA:45039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Fe(III)-[cytochrome c] + hydroxylamine <=> 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide
REACT:R-XTR-202917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 1 (Xenopus tropicalis)
REACT:R-RNO-8875320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 GEFs exchange GTP for GDP on RAB5 (Rattus norvegicus)
RHEA:36500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-rhamnonate + NAD(+) => 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH
REACT:R-SCE-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)
RHEA:36606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-enduracididine + O2 <=> (3S)-3-hydroxy-L-enduracididine + CO2 + succinate
RHEA:13963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate => ATP + H2O + Mg(2+) + protoporphyrin IX
REACT:R-DRE-3769383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBY1 binds beta-catenin (Danio rerio)
RHEA:42971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(56) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:57246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP
RHEA:60982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxododecanoate + H(+) + NADH => 12-hydroxydodecanoate + NAD(+)
REACT:R-RNO-9647645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD oligomerizes into arc-, slit-shaped structures (Rattus norvegicus)
REACT:R-BTA-4755419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1H4 with SUMO1 (Bos taurus)
RHEA:17639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hop-22(29)-ene => squalene
REACT:R-XTR-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Xenopus tropicalis)
RHEA:46549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine
GO:0050611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenite:azurin oxidoreductase activity
GO:0050611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate reductase (azurin) activity
GO:0050611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenite oxidase activity
REACT:R-XTR-211882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A7 can 6beta-hydroxylate testosterone (Xenopus tropicalis)
RHEA:57009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,5'-dehydrodivanillate + H(+) + NADH + O2 => 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)
RHEA:15630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] => an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]
REACT:R-DDI-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)
RHEA:56779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerol + a fatty acid + H(+) => a 1,2-diacylglycerol + H2O
REACT:R-XTR-68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Xenopus tropicalis)
REACT:R-GGA-2028692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK4 (p-MST1) by caspase 3 (Gallus gallus)
REACT:R-RNO-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Rattus norvegicus)
RHEA:55349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol => 9-cis-retinol
RHEA:31920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin(in) + H(+)(in) <=> (S)-allantoin(out) + H(+)(out)
REACT:R-CFA-2197770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1 (FEEL-1) binds ligands (Canis familiaris)
REACT:R-BTA-5654672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR1 (Bos taurus)
REACT:R-DDI-4568863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RAD52 with SUMO1 (Dictyostelium discoideum)
GO:0008028	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	monocarboxylate carrier
GO:0008028	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	prostaglandin/thromboxane transporter activity
GO:0008028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monocarboxylic acid transmembrane transporter activity
RHEA:30183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH
RHEA:30183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-galactonate 5-dehydrogenase"
RHEA:30183	skos:prefLabel	"L-galactonate 5-dehydrogenase"
REACT:R-CFA-8866329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP lipidates APOB-100, forming a pre-VLDL (Canis familiaris)
REACT:R-MMU-6799761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds PPP1R13L (Mus musculus)
RHEA:55732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)
RHEA:10758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + phosphoenolpyruvate => ATP + phosphate + pyruvate
RHEA:71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-glutamine(out) + Na(+)(out) <=> H(+)(out) + L-glutamine(in) + Na(+)(in)
REACT:R-HSA-168310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the RNP into the host cell nucleus (Homo sapiens)
RHEA:67096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + asnovolin A + 2 O2 = CO2 + fumigatonoid A + succinate
REACT:R-CFA-8983078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Canis familiaris)
RHEA:63085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + ilicicolin B + O2 => FAD + H(+) + 2 H2O + ilicicolin A
RHEA:24271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dioxo-6-phenylhexanoate + NADP(+) <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH
RHEA:54672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-kolavenyl diphosphate + H2O = (+)-kolavelool + diphosphate
RHEA:54672	skos:prefLabel	"(+)-kolavelool synthase"
RHEA:54672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-kolavelool synthase"
REACT:R-HSA-1655824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)
RHEA:42932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-5634228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 is cleaved by caspases (Mus musculus)
RHEA:40999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine
REACT:R-HSA-9757438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- translocates from cytosol to ER lumen of GI cells (Homo sapiens)
RHEA:21048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + isopropylamine + L-glutamate = ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate
RHEA:34658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + 2 S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:40093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxohexacosanoate + H(+) + NADH => 26-hydroxyhexacosanoate + NAD(+)
REACT:R-PFA-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Plasmodium falciparum)
RHEA:38452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + NADP(+) + n sulfur => NADPH + (n+1) sulfur
RHEA:51307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate
RHEA:31502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP
RHEA:63668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH
REACT:R-RNO-188002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rab5-mediated recruitment of class III PI3K to TLR9 (Rattus norvegicus)
REACT:R-CFA-9773803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKBKB phosphorylates NF-kappa-B inhibitor  (Canis familiaris)
RHEA:25063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH
REACT:R-GGA-8874201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L3 (Gallus gallus)
RHEA:71816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine(out) => 3,3',5'-triiodo-L-thyronine(in)
RHEA:70135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:60729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citral + H2O + NADP(+) => 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH
RHEA:59058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl disulfide + H(+) + NADH => 2 methanethiol + NAD(+)
REACT:R-CFA-8952419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs ubiquitinate RUNX3 (Canis familiaris)
RHEA:12024	skos:prefLabel	"sinapoylglucose--choline O-sinapoyltransferase"
RHEA:12024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sinapoylglucose--choline O-sinapoyltransferase"
RHEA:12024	skos:altLabel	"sinapine synthase"
RHEA:12024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-sinapoyl)-beta-D-glucose + choline = D-glucose + O-sinapoylcholine
REACT:R-XTR-9704248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM4 binds CHRM4 antagonists (Xenopus tropicalis)
REACT:R-HSA-5669024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD70 binds CD27 (Homo sapiens)
REACT:R-XTR-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Xenopus tropicalis)
REACT:R-SSC-2730858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of BTK/ITK (Sus scrofa)
RHEA:31470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-glucosyl) crocetin + UDP
REACT:R-DDI-5218891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomer binds MLKL (Dictyostelium discoideum)
RHEA:34257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-tetraprenyl-beta-curcumene + H2O => sporulenol
REACT:R-MMU-75883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHRS7B reduces GO3P to HXDG3P (Mus musculus)
REACT:R-RNO-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
REACT:R-RNO-3149494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC:cob(II)alamin binds MMADHC (Rattus norvegicus)
REACT:R-BTA-9706345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Bos taurus)
REACT:R-HSA-1791095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HERPUD (Homo sapiens)
REACT:R-CEL-9638127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G6P to G1P (Caenorhabditis elegans)
REACT:R-DME-2730894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)
RHEA:60040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate = (2E)-3-methylhex-2-enoate + L-glutamine
REACT:R-BTA-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Bos taurus)
GO:0008170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyltransferase activity
GO:0061627	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmethionine:homocysteine methyltransferase activity
GO:0061627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + S-methyl-L-methionine = H(+) + 2 L-methionine
GO:0061627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Homo sapiens)
GO:0061627	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homocysteine methyltransferase activity
GO:0061627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methylmethionine-homocysteine S-methyltransferase activity
GO:0061627	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homocysteine transmethylase activity
GO:0061627	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-methylmethionine homocysteine transmethylase activity
RHEA:39869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+) => 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol
REACT:R-HSA-9755757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 N binds TAK1 (Homo sapiens)
REACT:R-CFA-8855381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dephosphorylates ZAP70 (Canis familiaris)
RHEA:52387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + O-phospho-L-serine <=> H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate
RHEA:45354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxyoctadecanoate => 9,10-epoxyoctadecanoate + H2O
RHEA:68534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-CFA-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Canis familiaris)
RHEA:46427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:55302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate
RHEA:38764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
REACT:R-HSA-6807214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Homo sapiens)
REACT:R-CEL-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Caenorhabditis elegans)
GO:0047183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin 5-aromatic acyltransferase activity
GO:0047183	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity
REACT:R-BTA-983703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-SYK phosphorylates BLNK (SLP65) (Bos taurus)
REACT:R-SSC-265296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Sus scrofa)
RHEA:35355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisopentadecanoyl-CoA = (2E)-13-methyltetradecenoyl-CoA + H2O
REACT:R-RNO-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Rattus norvegicus)
REACT:R-SSC-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Sus scrofa)
GO:0015653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine:proton symporter activity
GO:0015653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine:hydrogen symporter activity
REACT:R-MMU-2066299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 binds phosphorylated WWTR1 (TAZ) (Mus musculus)
RHEA:36460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-proline + H2O => glycine + L-proline
REACT:R-SCE-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Saccharomyces cerevisiae)
RHEA:71549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-N(alpha)-glycyl-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + glycine
REACT:R-SSC-177275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates DARPP-32 on Thr34 (Sus scrofa)
GO:0047530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)
GO:0047530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diaminopentanoate dehydrogenase activity
GO:0047530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4-diaminopentanoic acid C4 dehydrogenase activity
GO:0047530	skos:prefLabel	"2,4-diaminopentanoate dehydrogenase"
GO:0047530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-diaminopentanoate dehydrogenase"
GO:0047530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)
RHEA:60397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-GGA-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Gallus gallus)
RHEA:22812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH
RHEA:22812	skos:prefLabel	"methylenetetrahydrofolate dehydrogenase (NADP(+))"
RHEA:22812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylenetetrahydrofolate dehydrogenase (NADP(+))"
GO:0090633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine 5'-monophospho-2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid synthetase activity
GO:0090633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity
GO:0090633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-KDN synthetase activity
RHEA:50759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + reduced [flavodoxin] <=> 2 H(+) + NADPH + oxidized [flavodoxin]
RHEA:53440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-390304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoASH (Canis familiaris)
RHEA:58281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 ATP => cyclic tetraadenylate + 4 diphosphate
REACT:R-SSC-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)
REACT:R-MMU-2993763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Mus musculus)
REACT:R-MMU-8849042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS3 (Mus musculus)
GO:0048487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-tubulin binding
GO:0048487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta tubulin binding
REACT:R-RNO-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Rattus norvegicus)
GO:0102293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pheophytinase b activity
RHEA:29777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1-phosphate + ATP
REACT:R-DDI-2161890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)
REACT:R-GGA-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Gallus gallus)
RHEA:61962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:39202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O
RHEA:34857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(cyanomethyl)glycine + NH4(+) => 2 H2O + iminodiacetonitrile
GO:0062061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAP complex binding
REACT:R-XTR-8944232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XII (Xenopus tropicalis)
REACT:R-SSC-2022851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfer GlcNAc to the heparan chain (Sus scrofa)
REACT:R-BTA-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)
RHEA:15118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + ATP => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine
REACT:R-SSC-373087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR6 binds CCL20 ligand (Sus scrofa)
RHEA:27596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-nonaprenyl diphosphate + 5 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate
REACT:R-SPO-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Schizosaccharomyces pombe)
REACT:R-RNO-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Rattus norvegicus)
REACT:R-CEL-1981128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Caenorhabditis elegans)
RHEA:56894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + UDP-beta-L-rhamnose => H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose
REACT:R-SPO-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Schizosaccharomyces pombe)
REACT:R-HSA-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Homo sapiens)
REACT:R-CEL-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Caenorhabditis elegans)
REACT:R-MMU-182990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty sequesters CBL away from active EGFR (Mus musculus)
RHEA:39969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminobutanoate => 2-aminobut-2-enoate
REACT:R-HSA-196126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from cytosol to mitochondrial intermembrane space (Homo sapiens)
REACT:R-MMU-9661419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds extracellular heme (Mus musculus)
RHEA:22159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H2O <=> GMP + H(+) + phosphate
REACT:R-XTR-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Xenopus tropicalis)
REACT:R-DRE-909724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IFNAR1 (Danio rerio)
REACT:R-DME-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)
REACT:R-GGA-4086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO2,3 (Gallus gallus)
RHEA:53815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]
RHEA:35719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-versiconol acetate + H2O = (S)-versiconol + acetate + H(+)
REACT:R-RNO-6784959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPHL hydrolyses VACV to ACV (Rattus norvegicus)
REACT:R-SSC-389762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PD-1 (Sus scrofa)
REACT:R-HSA-4655404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of AURKA with SUMO1 (Homo sapiens)
RHEA:42181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-9690439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds LTC4,LTD4,LTE4 (Drosophila melanogaster)
REACT:R-MMU-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Mus musculus)
REACT:R-XTR-976810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to extracellular Factor H:C3b (Xenopus tropicalis)
REACT:R-XTR-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Xenopus tropicalis)
REACT:R-DRE-9012657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Danio rerio)
RHEA:70492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-threonyl-[protein] => 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)
REACT:R-CFA-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Canis familiaris)
REACT:R-BTA-2022887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 N-deacetylates GlcNAc residues in heparan (Bos taurus)
REACT:R-XTR-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Xenopus tropicalis)
REACT:R-GGA-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Gallus gallus)
RHEA:52979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]
REACT:R-RNO-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Rattus norvegicus)
REACT:R-XTR-373748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD72 (Xenopus tropicalis)
REACT:R-MMU-1980044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 binds JAG2 (Mus musculus)
REACT:R-GGA-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Gallus gallus)
REACT:R-RNO-5654406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)
REACT:R-CEL-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Caenorhabditis elegans)
REACT:R-GGA-400682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Rac1 interacts with Plexin-B1:Sema4D (Gallus gallus)
RHEA:21780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexanone dehydrogenase"
RHEA:21780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cyclohexanone = AH2 + cyclohex-2-enone
RHEA:21780	skos:prefLabel	"cyclohexanone dehydrogenase"
RHEA:31871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-seco-amyrin synthase"
RHEA:31871	skos:prefLabel	"alpha-seco-amyrin synthase"
RHEA:31871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = alpha-seco-amyrin
REACT:R-HSA-1791157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DNAJC3 (p58IPK) (Homo sapiens)
REACT:R-SPO-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Schizosaccharomyces pombe)
RHEA:54043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> (3E,7E)-dolathalia-3,7,11-triene + diphosphate
REACT:R-BTA-193766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
RHEA:70616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]
RHEA:38333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol
REACT:R-BTA-2045911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
REACT:R-XTR-5682992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A,B bind H4K20Me2 (Xenopus tropicalis)
RHEA:15771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide phosphate + ADP + H(+) => adenosylcob(III)inamide + ATP
RHEA:40021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-ent-copalol + diphosphate => ent-copalyl diphosphate + H2O
REACT:R-XTR-8854182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D17 binds OPTN:RAB8A (Xenopus tropicalis)
RHEA:40918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-BTA-192137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
REACT:R-MMU-8875451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates CBL (Mus musculus)
REACT:R-XTR-3240957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PRC2-EZH2 complex (Xenopus tropicalis)
RHEA:27724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP => di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose
REACT:R-DRE-73931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Danio rerio)
RHEA:13725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate
RHEA:13725	skos:prefLabel	"glucosamine-1-phosphate N-acetyltransferase"
RHEA:13725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosamine-1-phosphate N-acetyltransferase"
GO:0102623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scutellarein 7-methyl ether 6-O-methyltransferase activity
REACT:R-CFA-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Canis familiaris)
REACT:R-MMU-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)
RHEA:69007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite <=> AMP + cremeomycin + diphosphate + H2O
GO:0044748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing
GO:0044748	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	exonucleolytic trimming to generate 3' end of miRNA
REACT:R-HSA-209910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is taken up by thyroid epithelial cells (Homo sapiens)
REACT:R-SSC-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Sus scrofa)
RHEA:23143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + H2O <=> D-ribose 5-phosphate + H(+) + nicotinamide
RHEA:15812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> (R)-linalool + diphosphate
RHEA:31624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-olivosyl-oleandolide + S-adenosyl-L-methionine => H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine
REACT:R-DME-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Drosophila melanogaster)
REACT:R-CEL-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Caenorhabditis elegans)
REACT:R-HSA-981648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binding protein binds C4bC2a (Homo sapiens)
GO:0102688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrozeatin UDP glycosyltransferase activity
REACT:R-DME-1655831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 translocates to the nucleus (Drosophila melanogaster)
REACT:R-RNO-2730837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-10Y-NTAL (Rattus norvegicus)
REACT:R-CFA-1433415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 (Canis familiaris)
REACT:R-HSA-8987012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Homo sapiens)
GO:0052894	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	norspermine oxidase activity
GO:0052894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norspermine:oxygen oxidoreductase activity
REACT:R-HSA-5662615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1X binds zinc (Homo sapiens)
RHEA:50167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)
RHEA:39359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)
REACT:R-BTA-6786034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Bos taurus)
REACT:R-BTA-9020262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Bos taurus)
REACT:R-RNO-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Rattus norvegicus)
RHEA:50935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
REACT:R-CFA-73945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAS-mediated dimerization of procaspase-8 (Canis familiaris)
EC:1.6.3.4	skos:altLabel	"H2O-forming NADH oxidase"
EC:1.6.3.4	skos:prefLabel	"NADH oxidase (H2O-forming)"
EC:1.6.3.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADH oxidase (H2O-forming)"
REACT:R-DME-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Drosophila melanogaster)
REACT:R-MMU-5685366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y-SHC (Mus musculus)
REACT:R-DDI-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Dictyostelium discoideum)
REACT:R-RNO-196417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of desmosterol to cholesterol (Rattus norvegicus)
GO:0046920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3-fucosyltransferase activity
GO:0046920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-(1->3)-fucosyltransferase activity
GO:0046920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Homo sapiens)
GO:0046920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha(1,3)-fucosyltransferase activity
GO:0046920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-(1,3)-fucosyltransferase activity
REACT:R-CEL-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Caenorhabditis elegans)
REACT:R-DME-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
RHEA:53304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 2 ATP + 2 cob(II)alamin = A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate
RHEA:18264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + precorrin-5 + S-adenosyl-L-methionine <=> acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine
REACT:R-DDI-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Dictyostelium discoideum)
RHEA:14372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phosphoglycolate + H2O <=> glycolate + phosphate
REACT:R-MMU-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Mus musculus)
REACT:R-HSA-1989762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ABCB4 (Homo sapiens)
RHEA:61197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
REACT:R-MMU-8953398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIR oxygenates quercetin (Mus musculus)
REACT:R-BTA-140355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS1 (Bos taurus)
RHEA:54093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)
RHEA:38405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O
RHEA:30486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Drosophila melanogaster)
GO:0047009	skos:prefLabel	"3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase"
GO:0047009	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	etiocholanolone 3-alpha-dehydrogenase activity
GO:0047009	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity
GO:0047009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity
GO:0047009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5beta-androstan-17-one + NAD(+) = 5beta-androstane-3,17-dione + H(+) + NADH
GO:0047009	skos:altLabel	"etiocholanolone 3alpha-dehydrogenase"
GO:0047009	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity
GO:0047009	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha-hydroxy-5beta-steroid dehydrogenase activity
GO:0047009	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	etiocholanolone 3alpha-dehydrogenase activity
GO:0047009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase"
RHEA:21854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H2O => (R)-10-hydroxyoctadecanoate
GO:0047008	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	21-hydroxysteroid:NADP+ 21-oxidoreductase activity
GO:0047008	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
GO:0047008	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	21-hydroxy steroid dehydrogenase activity
GO:0047008	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity
GO:0047008	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP-21-hydroxysteroid dehydrogenase activity
GO:0047008	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	21-hydroxysteroid dehydrogenase (NADP+) activity
GO:0047008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pregnan-21-ol dehydrogenase (NADP+) activity
REACT:R-DME-8938951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PAX5 (BSAP) (Drosophila melanogaster)
EC:3.5.1.2	skos:altLabel	"L-glutamine amidohydrolase"
EC:3.5.1.2	skos:prefLabel	"glutaminase"
EC:3.5.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutaminase"
REACT:R-CFA-211924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4B1 12-hydroxylates ARA (Canis familiaris)
RHEA:55812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine
REACT:R-DRE-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)
REACT:R-CFA-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Canis familiaris)
REACT:R-DRE-6799722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 oxidoreductase generates unstable semiquinones (Danio rerio)
REACT:R-DME-2396606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
REACT:R-DRE-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Danio rerio)
RHEA:25405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ethyl-2-hydroxy-3-oxobutanoate => (R)-3-hydroxy-3-methyl-2-oxopentanoate
REACT:R-GGA-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Gallus gallus)
REACT:R-CFA-451283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kainate receptor binds glutamate (Canis familiaris)
REACT:R-MMU-110011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Grb10 to the insulin receptor (Mus musculus)
REACT:R-BTA-6804468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO2 (Bos taurus)
RHEA:46963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:53195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
RHEA:66679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide <=> 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate
REACT:R-SCE-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Saccharomyces cerevisiae)
RHEA:33816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)
REACT:R-DRE-8866405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)
REACT:R-HSA-9632034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GlcA to chondroitin (Homo sapiens)
REACT:R-BTA-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Bos taurus)
RHEA:27553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate => (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate
RHEA:18703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate + 3 H(+) + 2 reduced [azurin] => arsenite + H2O + 2 oxidized [azurin]
REACT:R-SSC-8867044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EPS15, EPN1, EPS15L1 (Sus scrofa)
RHEA:64530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine => AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine
REACT:R-GGA-2132222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of factor B to form classical C3 convertase  (Gallus gallus)
RHEA:46642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH
RHEA:25227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arabinose + NADH => L-arabinitol + NAD(+)
RHEA:67144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + jasmonate + O2 = (1R,2R)-12-hydroxyjasmonate + CO2 + succinate
RHEA:61640	skos:altLabel	"IPCD"
RHEA:61640	skos:prefLabel	"isophthalyl-CoA decarboxylase"
RHEA:61640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isophthalyl-CoA = benzoyl-CoA + CO2
RHEA:61640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isophthalyl-CoA decarboxylase"
RHEA:60654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline => an N-(acyl)-sphingosylphosphocholine
REACT:R-BTA-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Bos taurus)
REACT:R-RNO-6808566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHGA-derived peptide binds the bacterial cell surface (Rattus norvegicus)
REACT:R-RNO-6814675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Rattus norvegicus)
REACT:R-XTR-158941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Xenopus tropicalis)
REACT:R-DME-2730849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)
RHEA:14256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 3',5'-bis(diphosphate) + H2O <=> diphosphate + GDP + H(+)
REACT:R-DRE-205289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of KIT (Danio rerio)
RHEA:30903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethylspheroidene O-methyltransferase"
RHEA:30903	skos:prefLabel	"demethylspheroidene O-methyltransferase"
RHEA:30903	skos:altLabel	"1-hydroxycarotenoid methylase"
RHEA:30903	skos:altLabel	"1-HO-carotenoid methylase"
RHEA:30903	skos:altLabel	"1-hydroxycarotenoid O-methylase"
RHEA:30903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylspheroidene + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + spheroidene
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydrogen ion translocating V-type ATPase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydrogen ion transporting two-sector ATPase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	F(0)F(1)-ATPase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FoF1-ATPase
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	F1-ATPase
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen ion transporting ATPase activity, rotational mechanism
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H+-transporting ATP synthase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP phosphohydrolase (H+-transporting) activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	F(1)-ATPase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial ATPase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton-transporting ATPase activity, rotational mechanism
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	chloroplast ATPase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	F(o)F(1)-ATPase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydrogen ion translocating F-type ATPase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydrogen ion translocating A-type ATPase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP synthase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H+-transporting ATPase activity
GO:0046961	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	F0F1-ATPase
REACT:R-BTA-8985900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Bos taurus)
RHEA:56402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+) => [(3R)-hydroxybutanoate](n) + H2O
REACT:R-MMU-5624953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL13B binds INPP5E (Mus musculus)
RHEA:32393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2R,4R)-dihydrocarveol + NAD(+)
REACT:R-BTA-5250930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH recruits histone acetyltransferases (Bos taurus)
REACT:R-MMU-159803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Mus musculus)
RHEA:29729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + FMN + 2 H(+) + H2O + sulfite => ethane-1-sulfonate + FMNH2 + O2
REACT:R-BTA-9708533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 translocates from the cytosol to the nucleoplasm (Bos taurus)
RHEA:71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) => chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)
REACT:R-DRE-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Danio rerio)
RHEA:64372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine
RHEA:51048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + A = AH2 + androst-4-ene-3,17-dione
REACT:R-RNO-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Rattus norvegicus)
REACT:R-XTR-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Xenopus tropicalis)
REACT:R-MMU-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Mus musculus)
REACT:R-DME-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)
REACT:R-PFA-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Plasmodium falciparum)
GO:0009378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	four-way junction helicase activity
GO:0009378	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Holliday junction helicase activity
GO:0009378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent four-way junction DNA helicase activity
GO:0009378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent four-way junction helicase activity
GO:0009378	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP-dependent Holliday junction helicase activity
REACT:R-CFA-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Canis familiaris)
REACT:R-DME-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Drosophila melanogaster)
REACT:R-RNO-2730840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Rattus norvegicus)
RHEA:28229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-9034042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Danio rerio)
REACT:R-DME-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Drosophila melanogaster)
REACT:R-MMU-1183128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Mus musculus)
REACT:R-HSA-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Homo sapiens)
RHEA:25604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)
REACT:R-DRE-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)
RHEA:47569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GD1b (d18:1(4E)) + H(+) + UDP
REACT:R-GGA-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Gallus gallus)
RHEA:46194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:56040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
REACT:R-DDI-6811414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF (Dictyostelium discoideum)
RHEA:19029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"allophanate hydrolase"
RHEA:19029	skos:prefLabel	"allophanate hydrolase"
RHEA:19029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + H2O + urea-1-carboxylate = 2 CO2 + 2 NH4(+)
REACT:R-HSA-164620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)
REACT:R-XTR-8952419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs ubiquitinate RUNX3 (Xenopus tropicalis)
RHEA:25878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + iminosuccinate => L-aspartate + O2
REACT:R-CFA-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Canis familiaris)
RHEA:65288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine
REACT:R-DME-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Drosophila melanogaster)
REACT:R-XTR-205306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP1 and KIT (Xenopus tropicalis)
RHEA:20834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + guanine(in) + H(+) + phosphate => ATP + guanine(out) + H2O
REACT:R-SSC-73932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resynthesis of excised residue by POLB (Sus scrofa)
REACT:R-CFA-5604929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C binds Protein S (Canis familiaris)
GO:0032454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K49 demethylase activity
GO:0032454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-methyl-lysine-9 demethylase activity
GO:0032454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity (H3-K9 specific)
GO:0032454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 demethylase activity
REACT:R-GGA-2681667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Gallus gallus)
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-directed DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA polymerase II
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	theta DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA polymerase beta
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA polymerase I
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Klenow fragment
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Tca DNA polymerase
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA duplicase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Taq Pol I
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA polymerase gamma
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic acid duplicase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nu DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	iota DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sigma DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA nucleotidyltransferase (DNA-directed) activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	deoxyribonucleic polymerase I
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-dependent DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mu DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	epsilon DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	duplicase
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	kappa DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA polymerase III
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gamma DNA-directed DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA polymerase alpha
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sequenase
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	eta DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	delta DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Taq DNA polymerase
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lambda DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA polymerase V activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic duplicase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	zeta DNA polymerase activity
GO:0003887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA replicase activity
RHEA:24100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diisopropyl-fluorophosphatase"
RHEA:24100	skos:altLabel	"OPAA"
RHEA:24100	skos:altLabel	"OPA anhydrase"
RHEA:24100	skos:prefLabel	"diisopropyl-fluorophosphatase"
RHEA:24100	skos:altLabel	"somanase"
RHEA:24100	skos:altLabel	"tabunase"
RHEA:24100	skos:altLabel	"DFPase"
RHEA:24100	skos:altLabel	"organophosphorus acid anhydrolase"
RHEA:24100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H(+)
REACT:R-CEL-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Caenorhabditis elegans)
RHEA:16905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine
RHEA:35539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2
RHEA:16109	skos:prefLabel	"6-phosphofructokinase"
RHEA:16109	skos:altLabel	"phosphohexokinase"
RHEA:16109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-phosphofructokinase"
RHEA:16109	skos:altLabel	"phosphofructokinase I"
RHEA:16109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)
REACT:R-DDI-5649854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to oxidatively damaged AP site (Dictyostelium discoideum)
RHEA:70229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-benzylidenesuccinyl-CoA + H2O => (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA
EC:3.4.14.13	skos:prefLabel	"gamma-D-glutamyl-L-lysine dipeptidyl-peptidase"
EC:3.4.14.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-D-glutamyl-L-lysine dipeptidyl-peptidase"
REACT:R-HSA-2130504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of lip22 to lip10 (Homo sapiens)
REACT:R-HSA-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Homo sapiens)
REACT:R-HSA-3222093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 binds TP53 and EP300 (Homo sapiens)
GO:0003933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP cyclohydrolase activity
REACT:R-DRE-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Danio rerio)
RHEA:41632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine
RHEA:32922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl (indol-3-yl)acetate <=> (indol-3-yl)acetate + H(+) + methanol
RHEA:39192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-docosenoyl-CoA + H(+) + NADPH => docosanoyl-CoA + NADP(+)
RHEA:25911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alditol + O2 <=> an aldose + H2O2
GO:0004802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transketolase activity
GO:0004802	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity
GO:0004802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoaldehyde transferase activity
GO:0004802	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity
GO:0004802	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolaldehydetransferase activity
REACT:R-HSA-432952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP180 interacts intracellularly with plectin and integrin beta4 (Homo sapiens)
REACT:R-DME-110141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Drosophila melanogaster)
REACT:R-RNO-5603114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Rattus norvegicus)
REACT:R-XTR-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Xenopus tropicalis)
RHEA:55604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base
RHEA:24245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pseudotropine => H(+) + NADPH + tropinone
RHEA:24625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonine + tRNA(Thr) => AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)
RHEA:47629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + propanoyl-CoA => 3-methylmalate + CoA + H(+)
EC:1.12.99.-	skos:prefLabel	"With other acceptors"
EC:1.12.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
REACT:R-CFA-5685606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC2D binds KLRB1 (Canis familiaris)
REACT:R-SSC-9714483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the ER membrane (Sus scrofa)
REACT:R-BTA-913371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF receptor alpha:GM-CSF binds Bc (Bos taurus)
RHEA:22020	skos:altLabel	"molybdate ABC transporter"
RHEA:22020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + molybdate(out) = ADP + H(+) + molybdate(in) + phosphate
RHEA:22020	skos:prefLabel	"ABC-type molybdate transporter"
RHEA:22020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type molybdate transporter"
RHEA:22020	skos:altLabel	"molybdate-transporting ATPase"
RHEA:52183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:14824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-arabinopyranose <=> L-ribulose
RHEA:33236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 => 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)
REACT:R-DME-5357831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD is phosphorylated by IKK (Drosophila melanogaster)
REACT:R-CFA-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Canis familiaris)
RHEA:47549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-4-en-24-oate => 3-oxochola-4,6-dien-24-oate + H2O
RHEA:54141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(49) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
GO:0047165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAT-3
GO:0047165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity
GO:0047165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity
GO:0047165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol-3-O-beta-glucoside O-malonyltransferase activity
GO:0047165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 3-O-glucoside malonyltransferase activity
REACT:R-MMU-5654586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS binds GRB2:SOS1 (Mus musculus)
REACT:R-CFA-9627089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP9 is phosphorylated at T125 (Canis familiaris)
RHEA:47544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine
RHEA:48240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1b + H(+)
RHEA:10077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lactose => beta-D-galactose + D-glucose
REACT:R-DRE-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Danio rerio)
RHEA:23412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylputrescine = acetate + putrescine
RHEA:23412	skos:prefLabel	"acetylputrescine deacetylase"
RHEA:23412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylputrescine deacetylase"
EC:3.2.1.n1	skos:prefLabel	"blood group B branched chain alpha-1,3-galactosidase"
EC:3.2.1.n1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"blood group B branched chain alpha-1,3-galactosidase"
REACT:R-BTA-5218836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2beta binds alphaVbeta3 (Bos taurus)
REACT:R-GGA-5617828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIP11:IFT20 dissociates (Gallus gallus)
RHEA:72768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH => 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)
RHEA:20605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytosine deaminase"
RHEA:20605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine + H(+) + H2O = NH4(+) + uracil
RHEA:20605	skos:altLabel	"Cytosine aminohydrolase"
RHEA:20605	skos:prefLabel	"cytosine deaminase"
REACT:R-RNO-211881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A13 (Rattus norvegicus)
RHEA:52321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tryptamine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin
REACT:R-XTR-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Xenopus tropicalis)
REACT:R-SCE-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Saccharomyces cerevisiae)
REACT:R-RNO-6814671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of late-endosome derived vesicles at the TGN (Rattus norvegicus)
RHEA:39918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycerol + phosphate
RHEA:52374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol + 3'-phosphoadenylyl sulfate
REACT:R-RNO-2730889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to the membrane by binding active RAC1 (Rattus norvegicus)
REACT:R-CFA-8987039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL20RA (Canis familiaris)
REACT:R-PFA-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Plasmodium falciparum)
GO:0043870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-aminoadipate semialdehyde dehydrogenase activity
GO:0043870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-gamma-aminoadipyl-phosphate reductase activity
GO:0043870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-glutamyl-phosphate reductase activity
GO:0043870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ArgC
GO:0043870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LysY
GO:0043870	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAGSA dehydrogenase activity
GO:0043870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AGPR
REACT:R-HSA-158925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Homo sapiens)
REACT:R-DRE-2250301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyrrole cross-links (Danio rerio)
RHEA:20194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + NADP(+) => H(+) + mevaldate + NADPH
GO:0004386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent helicase activity
GO:0004386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	helicase activity
REACT:R-BTA-193052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione isomerizes to progesterone (Bos taurus)
REACT:R-DRE-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Danio rerio)
GO:1904091	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PCP
GO:1904091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-ribosomal peptide synthetase activity
GO:1904091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process
GO:1904091	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyl carrier protein
GO:1904091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis
GO:1904091	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyl carrier protein activity
GO:0047514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-glucan:orthophosphate glucosyltransferase activity
GO:0047514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-beta-D-glucan phosphorylase activity
GO:0047514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-beta-glucan phosphorylase activity
GO:0047514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity
GO:0047514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	laminarin phosphorylase activity
GO:0047514	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	laminarin phosphoryltransferase activity
GO:0016853	skos:prefLabel	"Isomerases"
GO:0016853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomerase activity
GO:0016853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Isomerases"
GO:0016853	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	other isomerase activity
GO:0016853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Homo sapiens)
RHEA:61702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + glycyl-[peptidyl-carrier protein] + H(+) => glycyl-5'-AMP + holo-[peptidyl-carrier protein]
REACT:R-CFA-2029455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIA with IgG-coated Ag (Canis familiaris)
RHEA:25217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + serotonin = CoA + H(+) + N-acetylserotonin
REACT:R-HSA-157353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEXT1 is cleaved to produce NICD1 (Homo sapiens)
RHEA:69379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydodecanoate + O2 <=> 2-oxododecanoate + H2O2
REACT:R-DRE-9609310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β-blockers bind ADRB1,2,3 (Danio rerio)
RHEA:36973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-allose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose
REACT:R-XTR-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Xenopus tropicalis)
EC:3.2.1.25	skos:altLabel	"mannase"
EC:3.2.1.25	skos:prefLabel	"beta-mannosidase"
EC:3.2.1.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-mannosidase"
EC:3.2.1.25	skos:altLabel	"mannanase"
REACT:R-PFA-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Plasmodium falciparum)
REACT:R-GGA-433845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chicken RIP1 facilitates IKKs complex activation (Gallus gallus)
GO:0034837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity
RHEA:60096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH
GO:0070287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferritin receptor activity
GO:0070287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferritin complex receptor activity
REACT:R-MMU-1006143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C3b (Mus musculus)
REACT:R-BTA-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Bos taurus)
RHEA:57612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH = 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)
REACT:R-BTA-374663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Ezrin (Bos taurus)
REACT:R-HSA-429786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Homo sapiens)
REACT:R-DRE-5693583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDC1 associates with gamma-H2AFX at nuclear foci (Danio rerio)
RHEA:44411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)
REACT:R-CEL-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Caenorhabditis elegans)
REACT:R-HSA-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Homo sapiens)
RHEA:33615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA
REACT:R-DME-8876312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Drosophila melanogaster)
RHEA:57756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
RHEA:57756	skos:prefLabel	"(phenol)carboxyphthiodiolenone synthase"
RHEA:57756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(phenol)carboxyphthiodiolenone synthase"
REACT:R-GGA-5668454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Gallus gallus)
REACT:R-CEL-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Caenorhabditis elegans)
RHEA:48394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose
GO:0034842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiophene-2-carboxylate-CoA ligase activity
REACT:R-DRE-163670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear transport of pChREBP (Thr 666) protein (Danio rerio)
REACT:R-DME-73912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Drosophila melanogaster)
RHEA:42998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-cembrene A + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-XTR-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)
REACT:R-CFA-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)
REACT:R-HSA-9669855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dasatinib-resistant KIT mutants do not bind dasatinib (Homo sapiens)
REACT:R-MMU-8870732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSGs bind proteoglycans and TGF-beta1 (Mus musculus)
RHEA:59111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + octyl beta-D-glucose <=> beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol
REACT:R-CFA-3780997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG2:GYS2 (Canis familiaris)
REACT:R-HSA-9626253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8 binds LAMP2a multimers (Homo sapiens)
RHEA:63683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-7,8-diammoniononanoate + CO2 <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)
REACT:R-MMU-6791219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Mus musculus)
RHEA:29641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + D-maltopentaose => D-maltohexaose + H2O
RHEA:25451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-guaia-6,9-diene + diphosphate
REACT:R-BTA-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Bos taurus)
REACT:R-RNO-5686587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates RAD52 (Rattus norvegicus)
REACT:R-MMU-388811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-1 homodimer (Mus musculus)
RHEA:10070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose
REACT:R-CFA-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Canis familiaris)
REACT:R-DDI-450490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B/Akt phosphorylates BRF1 (Dictyostelium discoideum)
REACT:R-DME-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Drosophila melanogaster)
REACT:R-XTR-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Xenopus tropicalis)
REACT:R-HSA-5654659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
REACT:R-CFA-9011981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 is recruited to MYC and BCL2 genes (Canis familiaris)
REACT:R-DME-3322009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Drosophila melanogaster)
REACT:R-CEL-8944232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XII (Caenorhabditis elegans)
REACT:R-XTR-430076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds 14-3-3-zeta (Xenopus tropicalis)
REACT:R-CFA-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Canis familiaris)
RHEA:23084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate
RHEA:23084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-3-isohexenylglutaryl-CoA lyase"
RHEA:23084	skos:altLabel	"3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase"
RHEA:23084	skos:prefLabel	"3-hydroxy-3-isohexenylglutaryl-CoA lyase"
REACT:R-DME-8942099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Drosophila melanogaster)
REACT:R-MMU-5654655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PPTN11 (Mus musculus)
RHEA:16312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + taurochenodeoxycholate <=> chenodeoxycholate + taurine
REACT:R-XTR-1168642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Xenopus tropicalis)
RHEA:33618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + octadecanoate <=> AMP + diphosphate + octadecanoyl-CoA
RHEA:52517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline + ubiquinone-10 => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10
GO:0047827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
GO:0047827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D(+)-lysopine dehydrogenase activity
GO:0047827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lysopine synthase activity
GO:0047827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
GO:0047827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysopine dehydrogenase activity
GO:0047827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysopine dehydrogenase activity
RHEA:23248	skos:prefLabel	"inositol 4-methyltransferase"
RHEA:23248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol 4-methyltransferase"
RHEA:23248	skos:altLabel	"myo-inositol 4-O-methyltransferase"
RHEA:23248	skos:altLabel	"myo-inositol 6-O-methyltransferase"
RHEA:23248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + S-adenosyl-L-methionine = 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine
RHEA:23248	skos:altLabel	"S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase"
RHEA:30221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfone + H(+) + NADH => dimethyl sulfoxide + H2O + NAD(+)
RHEA:40195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA
GO:0103067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity
GO:0103067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carboxylate + NADP(+) = 3-dehydro-4-methylzymosterol + CO2 + NADPH
RHEA:39138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2
REACT:R-HSA-4839635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
REACT:R-HSA-389348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by pVav1 (Homo sapiens)
REACT:R-GGA-2002460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB binds Collagen chains (Gallus gallus)
REACT:R-DRE-8852324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds PLK1 (Danio rerio)
REACT:R-SPO-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Schizosaccharomyces pombe)
REACT:R-HSA-174706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Homo sapiens)
RHEA:47840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate
RHEA:47840	skos:prefLabel	"(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase"
RHEA:47840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase"
RHEA:53098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine
REACT:R-GGA-937337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Gallus gallus)
RHEA:20520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-galactosamine
REACT:R-BTA-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Bos taurus)
RHEA:25317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-acetamido-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate
REACT:R-RNO-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)
RHEA:36516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + tetracosanoyl-CoA => 3-oxohexacosanoyl-CoA + CO2 + CoA
REACT:R-XTR-196950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTRAP hydrolyzes FMN to RIB (Xenopus tropicalis)
REACT:R-MMU-2160851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAS1,2,3 mediate the polymerisation of HA (Mus musculus)
REACT:R-BTA-5357757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAE-III
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxycinnamoyl esterase activity
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAEA
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cinnAE
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hemicellulase accessory
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferulic acid esterase activity
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAE-II
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinnamoyl ester hydrolase activity
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	feruloyl esterase activity
GO:0030600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAE-I
RHEA:34409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate => 3 ATP
REACT:R-BTA-8949649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Bos taurus)
REACT:R-MMU-390427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Mus musculus)
REACT:R-BTA-5690157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP16,USP21 deubiquitinate Histone H2A (Bos taurus)
REACT:R-MMU-964811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5AR2 binds anaphylatoxins and thier desArginated derivatives (Mus musculus)
REACT:R-BTA-8876615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB13 GEFs exchange GTP for GDP on RAB13 (Bos taurus)
REACT:R-DDI-8938815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 polyubiquitinates RRAGA (Dictyostelium discoideum)
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDH
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphoglucose dehydrogenas
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	G6PD activity
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-6-phosphate 1-dehydrogenase activity
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-6-phosphate dehydrogenase activity
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PDH
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Entner-doudoroff enzyme
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Zwischenferment
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose 6-phosphate dehydrogenase (NADP) activity
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP-dependent glucose 6-phosphate dehydrogenase activity
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phosphoglucose dehydrogenase activity
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP-glucose-6-phosphate dehydrogenase activity
GO:0004345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate dehydrogenase activity
REACT:R-HSA-2730885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)
RHEA:51511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-proline + O2 <=> CO2 + succinate + trans-4-hydroxy-L-proline
RHEA:29206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + menaquinol-8 <=> dimethyl sulfide + H2O + menaquinone-8
RHEA:58331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-non-6-en-1-ol + NADP(+) <=> (Z)-non-6-enal + H(+) + NADPH
REACT:R-XTR-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Xenopus tropicalis)
REACT:R-DRE-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Danio rerio)
RHEA:43151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine
REACT:R-DRE-8959719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPK phosphorylates Sedo to Sedo7P (Danio rerio)
RHEA:39873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
RHEA:69372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexanoate + O2 = 2-oxohexanoate + H2O2
REACT:R-MMU-8939688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) complex binds RUNX2 (Mus musculus)
REACT:R-GGA-5682965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Gallus gallus)
REACT:R-CFA-9706319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA (Canis familiaris)
RHEA:29776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate + ATP => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)
REACT:R-HSA-5676597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Homo sapiens)
GO:0030778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	columbamine O-methyltransferase activity
GO:0030778	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:columbamine O-methyltransferase activity
RHEA:37547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + NAD(+) = 3-dehydro-D-glucose 6-phosphate + H(+) + NADH
RHEA:37547	skos:prefLabel	"glucose-6-phosphate 3-dehydrogenase"
RHEA:37547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-6-phosphate 3-dehydrogenase"
RHEA:63806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-galactose => GDP-beta-L-gulose
RHEA:49730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 H2O + NADP(+) + violacein => 2 H(+) + NADPH + 2 O2 + protoviolaceinate
REACT:R-DDI-446364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Migfilin interacts with VASP (Dictyostelium discoideum)
RHEA:57279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA
REACT:R-DRE-6811412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer to the Golgi (Danio rerio)
GO:0010855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylate cyclase inhibitor activity
RHEA:10609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] => (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (1R,5R)-beta-pinene + diphosphate
RHEA:12734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + diphosphate + nicotinate beta-D-ribonucleotide => 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate
RHEA:72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in)
RHEA:32716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-methylmalate + NAD(+) => 2-oxobutanoate + CO2 + NADH
REACT:R-CEL-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Caenorhabditis elegans)
REACT:R-SPO-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Schizosaccharomyces pombe)
REACT:R-DME-450358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Drosophila melanogaster)
REACT:R-DRE-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Danio rerio)
REACT:R-RNO-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Rattus norvegicus)
REACT:R-BTA-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Bos taurus)
REACT:R-HSA-5665802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)
REACT:R-XTR-9606894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DAPP1 (p-BAM32) binds PLCG2 (Xenopus tropicalis)
RHEA:13109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetamidofluorene + H2O + NAD(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADH
RHEA:13109	skos:altLabel	"N-hydroxy-2-acetylaminofluorene reductase"
RHEA:13109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetamidofluorene + H2O + NADP(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADPH
RHEA:13109	skos:prefLabel	"N-hydroxy-2-acetamidofluorene reductase"
RHEA:13109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-hydroxy-2-acetamidofluorene reductase"
RHEA:63737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + H(+) + NADPH => 2-phenylethanol + NADP(+)
REACT:R-DRE-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Danio rerio)
RHEA:13737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH
REACT:R-XTR-5654677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR2 (Xenopus tropicalis)
RHEA:16885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 bilirubin-glucuronoside = bilirubin IXalpha + bilirubin-bisglucuronoside
REACT:R-GGA-9033527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Gallus gallus)
RHEA:59511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + L-cysteinyl-[protein] <=> S-(2-succinyl)-L-cysteinyl-[protein]
REACT:R-MMU-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Mus musculus)
EC:1.1.1.360	skos:altLabel	"glucose (galactose) dehydrogenase"
EC:1.1.1.360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose/galactose 1-dehydrogenase"
EC:1.1.1.360	skos:altLabel	"dual-specific glucose/galactose dehydrogenase"
EC:1.1.1.360	skos:altLabel	"glucose/galactose dehydrogenase"
EC:1.1.1.360	skos:prefLabel	"glucose/galactose 1-dehydrogenase"
REACT:R-SSC-2160915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor-mediated uptake of HA (Sus scrofa)
GO:0034450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E4
GO:0034450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-ubiquitin ligase activity
REACT:R-CFA-8852167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:Catecholamine binds ARRB1, ARRB2 (Canis familiaris)
REACT:R-SSC-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Sus scrofa)
RHEA:58614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-octanoylglycine + O2
REACT:R-RNO-5654658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS bind to PPTN11 (Rattus norvegicus)
RHEA:10743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + NAD(+) <=> a ketone + H(+) + NADH
RHEA:72410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + Li(+)(out) <=> H(+)(out) + Li(+)(in)
RHEA:31878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> marneral
REACT:R-MMU-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Mus musculus)
REACT:R-MMU-1675473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B binds JAK2 (Mus musculus)
RHEA:40581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-HSA-173642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disintegration of matrix layer (Homo sapiens)
REACT:R-RNO-5685318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex formation (Rattus norvegicus)
REACT:R-MMU-174931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Mus musculus)
REACT:R-DRE-8875490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind ubiquitinated MET (Danio rerio)
REACT:R-DRE-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Danio rerio)
RHEA:36009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA
REACT:R-HSA-1592245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRF1:PPARGC1B binds the ALAS1 promoter (Homo sapiens)
RHEA:29099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 5 H(+)(in) + NADH = a menaquinol + 4 H(+)(out) + NAD(+)
REACT:R-DME-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Drosophila melanogaster)
RHEA:49462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O
REACT:R-SSC-8851044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN1A1 binds xanthine oxidoreductase (XDH) (Sus scrofa)
REACT:R-SSC-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Sus scrofa)
RHEA:33836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoate
RHEA:15344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide <=> ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate
REACT:R-DME-392835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 sequesters Raf1 to inhibit ERK cascade (Drosophila melanogaster)
RHEA:58729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine in rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine
REACT:R-MMU-202727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaMbeta2 (MAC1) binds JAM3 (Mus musculus)
RHEA:72767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH = 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)
GO:0034892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endosulfan lactone lactonase activity
RHEA:60748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin II
RHEA:52785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfenohercynine + AH2 + H(+) => A + ergothioneine + H2O
RHEA:11613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + NADPH + NH4(+)
GO:0032140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single adenine insertion binding
RHEA:60136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate
REACT:R-CFA-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
RHEA:48046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + ganglioside GM2 (d18:1(4E)/18:0) => ganglioside GM1 (d18:1(4E)/18:0) + H2O
REACT:R-CFA-1250346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)
REACT:R-DRE-9734070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET recombinant therapeutic antibodies bind MET (Danio rerio)
REACT:R-HSA-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Homo sapiens)
RHEA:53168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-DRE-9627106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) forms dimer (Danio rerio)
REACT:R-XTR-193845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)
REACT:R-XTR-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Xenopus tropicalis)
RHEA:47405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH
REACT:R-CFA-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
REACT:R-SSC-430347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MigFilin associates with Filamin and F-actin (Sus scrofa)
REACT:R-CFA-9621179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cinaciguat binds sGC:NO (Canis familiaris)
RHEA:23971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + H2O + NAD(+) <=> (E)-ferulate + 2 H(+) + NADH
REACT:R-XTR-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Xenopus tropicalis)
REACT:R-CFA-2299620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen XI cross-links with collagen II (Canis familiaris)
REACT:R-XTR-6787820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds CSF1R (Xenopus tropicalis)
RHEA:71961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(in) + oxaloacetate(in) => 3 Na(+)(out) + oxaloacetate(out)
GO:0047785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol sulphotransferase activity
GO:0047785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity
GO:0047785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucocorticoid sulfotransferase activity
GO:0047785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol sulfotransferase activity
GO:0047785	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glucocorticosteroid sulfotransferase activity
REACT:R-DDI-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Dictyostelium discoideum)
RHEA:15763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate 4-semialdehyde + NADPH => L-homoserine + NADP(+)
RHEA:63455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized 3PG-factor420-0
RHEA:10680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline = D-proline
RHEA:10680	skos:prefLabel	"proline racemase"
RHEA:10680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"proline racemase"
RHEA:43318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP
REACT:R-HSA-4396371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 Coactivator Complex binds MYC promoter (Homo sapiens)
REACT:R-DRE-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Danio rerio)
REACT:R-BTA-2473151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister centromeres (Bos taurus)
REACT:R-DME-1475026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (cytosol) (Drosophila melanogaster)
REACT:R-RNO-508513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B binds JAK3 (Rattus norvegicus)
REACT:R-DDI-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Dictyostelium discoideum)
RHEA:42545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(32) in tRNA => pseudouridine(32) in tRNA
REACT:R-CFA-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)
REACT:R-DME-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Drosophila melanogaster)
RHEA:20105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-fructose 6-phosphate = AMP + beta-D-fructose 1,6-bisphosphate + H(+)
RHEA:20105	skos:prefLabel	"ADP-specific phosphofructokinase"
RHEA:20105	skos:altLabel	"ADP-dependent phosphofructokinase"
RHEA:20105	skos:altLabel	"ADP-6-phosphofructokinase"
RHEA:20105	skos:altLabel	"ADP-Pfk"
RHEA:20105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-specific phosphofructokinase"
REACT:R-DME-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)
RHEA:51338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2
RHEA:16646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoyl-CoA => CoA + H(+) + hexadecanoate
REACT:R-GGA-9647645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD oligomerizes into arc-, slit-shaped structures (Gallus gallus)
RHEA:14223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methanol + sulfate => H2O + monomethyl sulfate
REACT:R-DRE-8848713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds BCAR1 (Danio rerio)
RHEA:13428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine ribonucleoside 5'-phosphate + H2O <=> a pyrimidine nucleobase + D-ribose 5-phosphate
REACT:R-XTR-202510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1-TAB2 complex (Xenopus tropicalis)
REACT:R-BTA-2025723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the N-glycan precursor (Bos taurus)
RHEA:58027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleanolate + UDP-alpha-D-glucose <=> H(+) + oleanolate 3-O-beta-D-glucoside + UDP
REACT:R-RNO-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Rattus norvegicus)
RHEA:17110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)
REACT:R-DDI-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-BTA-211951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1B1 4-hydroxylates EST17b (Bos taurus)
REACT:R-DRE-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Danio rerio)
REACT:R-BTA-201486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand pleiotrophin (PTN) (Bos taurus)
GO:0102792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapaldehyde:NAD(P)+ oxidoreductase activity
REACT:R-HSA-354066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PTK2 to Focal complexes (Homo sapiens)
REACT:R-RNO-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Rattus norvegicus)
REACT:R-DME-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Drosophila melanogaster)
REACT:R-RNO-77342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Rattus norvegicus)
RHEA:52648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arabino-1,4-lactone 5-phosphate = 5-phospho-L-arabinonate + H(+)
REACT:R-MMU-75886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Mus musculus)
REACT:R-RNO-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Rattus norvegicus)
REACT:R-RNO-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-DME-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Drosophila melanogaster)
RHEA:38032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2
REACT:R-SSC-5649801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Sus scrofa)
RHEA:38777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
REACT:R-DME-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
REACT:R-GGA-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Gallus gallus)
REACT:R-CEL-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Caenorhabditis elegans)
REACT:R-DME-8939706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) polyubiquitinates RUNX2 (Drosophila melanogaster)
REACT:R-SPO-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)
REACT:R-SPO-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Schizosaccharomyces pombe)
RHEA:57776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-6-nitrotoluene + NADH + O2 = 4-chloro-3-methylcatechol + NAD(+) + nitrite
GO:0102840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity
GO:0015607	skos:prefLabel	"ABC-type fatty-acyl-CoA transporter"
GO:0015607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA(out) + ATP + H2O = ADP + an acyl-CoA(in) + H(+) + phosphate
GO:0015607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty-acyl-CoA-transporting ATPase
GO:0015607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type fatty-acyl-CoA transporter activity
GO:0015607	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fatty-acyl-CoA transmembrane transporter activity
GO:0015607	skos:altLabel	"fatty-acyl-CoA-transporting ATPase"
GO:0015607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acyl CoA transporter activity
GO:0015607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type fatty-acyl-CoA transporter"
GO:0015607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled fatty-acyl-CoA transmembrane transporter activity
GO:0015607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type fatty-acyl-CoA transporter
REACT:R-CEL-2028284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Caenorhabditis elegans)
RHEA:59735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinyl-5'-AMP + L-lysyl-[protein] <=> AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]
RHEA:60705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine
REACT:R-CFA-5685607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sialic acid binds SIGLEC (Canis familiaris)
REACT:R-GGA-2562526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates OPTN (Gallus gallus)
REACT:R-SSC-9684627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds CYSLTR1 antagonists (Sus scrofa)
REACT:R-GGA-8877813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND5A,B exchange GTP for GDP on RAB39 (Gallus gallus)
REACT:R-MMU-9013023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GEFs activate RHOB (Mus musculus)
REACT:R-XTR-5684248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
REACT:R-DRE-6811508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2-bound EP300 acetylates TP53 (Danio rerio)
REACT:R-DRE-449829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11 binds IL11RA (Danio rerio)
REACT:R-CFA-8863973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of ERC and phagosome (Canis familiaris)
GO:0042926	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyphenylpropionic acid transporter activity
GO:0042926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	m-hydroxyphenylpropionic acid transporter activity
GO:0042926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylpropionic acid transmembrane transporter activity
GO:0042926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)propionic acid transporter activity
REACT:R-SSC-5362441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Sus scrofa)
GO:0050281	skos:altLabel	"serine--glyoxylate aminotransferase"
GO:0050281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-glyoxylate transaminase activity
GO:0050281	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine:glyoxylate aminotransferase activity
GO:0050281	skos:prefLabel	"serine--glyoxylate transaminase"
GO:0050281	skos:altLabel	"SGAT"
GO:0050281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine--glyoxylate aminotransferase activity
GO:0050281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-serine = 3-hydroxypyruvate + glycine
GO:0050281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine--glyoxylate transaminase"
GO:0050281	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SGAT activity
REACT:R-CEL-9634861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT2 (Caenorhabditis elegans)
REACT:R-DME-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Drosophila melanogaster)
REACT:R-RNO-9647977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT methylates S-Farn RAS proteins (Rattus norvegicus)
RHEA:56006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)
REACT:R-RNO-2029475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of AA by iPLA2 upon FCGR activation (Rattus norvegicus)
RHEA:67866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]
RHEA:65091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] <=> asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1592387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin binds elastic fibres (Homo sapiens)
REACT:R-HSA-5685296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GATA6 binds SFTPA genes (Homo sapiens)
REACT:R-DME-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Drosophila melanogaster)
REACT:R-HSA-1483170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS transports from the ER membrane to the IM membrane (Homo sapiens)
EC:5.5.1.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lycopene beta-cyclase"
EC:5.5.1.19	skos:prefLabel	"lycopene beta-cyclase"
REACT:R-BTA-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)
GO:0008079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation termination factor activity
RHEA:18671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + D-ribose => adenosine + H2O
RHEA:31423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate
REACT:R-HSA-5684801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y7-CLEC1B dimer:PDPN binds SYK (Homo sapiens)
GO:0050265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(U) polymerase activity
GO:0050265	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TUT activity
GO:0050265	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	terminal uridylyltransferase activity
GO:0050265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA uridylyltransferase activity
GO:0050265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polynucleotide uridylyltransferase activity
GO:0050265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP:RNA uridylyltransferase activity
REACT:R-HSA-110236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG) (Homo sapiens)
REACT:R-CFA-5649725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Canis familiaris)
REACT:R-CFA-5691006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Canis familiaris)
RHEA:12787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldose + H(+) + NADH => an alditol + NAD(+)
RHEA:39919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O = 1-O-(alk-1-enyl)-sn-glycerol + phosphate
REACT:R-HSA-2038944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity (Homo sapiens)
REACT:R-DRE-429529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin binding to GP1b:IX:V (Danio rerio)
REACT:R-MMU-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Mus musculus)
REACT:R-MMU-202718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Mus musculus)
REACT:R-DRE-2161959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Danio rerio)
RHEA:70729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-alpha-D-quinovose + glycerol => 3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O
REACT:R-XTR-5661124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR4-HIST1H4 (Xenopus tropicalis)
REACT:R-RNO-5654673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Rattus norvegicus)
RHEA:28719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine(in) + H(+)(in) = adenine(out) + H(+)(out)
EC:1.4.3.-	skos:prefLabel	"With oxygen as acceptor"
EC:1.4.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
REACT:R-CFA-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Canis familiaris)
RHEA:70332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetyl-CoA + H2O => 3-hydroxyphenylacetate + CoA + H(+)
REACT:R-MMU-5694441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1D phosphorylates SEC23 (Mus musculus)
RHEA:28222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + ATP = 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)
RHEA:13823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + CO2 + succinate => 2-oxoglutarate + glutarate + O2
RHEA:52669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH
RHEA:71411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) = 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)
RHEA:22601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-9-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate
REACT:R-GGA-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Gallus gallus)
REACT:R-MMU-5660662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASC binds Caspase-8 complex (Mus musculus)
REACT:R-DME-2028670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Drosophila melanogaster)
RHEA:66902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O => acetyl-CoA + L-tryptophan + malonyl-CoA
REACT:R-CEL-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Caenorhabditis elegans)
REACT:R-SSC-5218815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds NCK (Sus scrofa)
REACT:R-RNO-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Rattus norvegicus)
RHEA:41378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
REACT:R-SSC-1971487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHSY3 transfer GalNAc to chondroitin (Sus scrofa)
RHEA:43874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate => 3-oxochol-4-en-22-oate + ATP + CoA
RHEA:34620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxypentalenate + 2-oxoglutarate + O2 => 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate
REACT:R-DDI-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Dictyostelium discoideum)
REACT:R-BTA-2161187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Bos taurus)
REACT:R-SCE-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Saccharomyces cerevisiae)
REACT:R-XTR-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Xenopus tropicalis)
RHEA:20636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + L-ornithine <=> a lyso-ornithine lipid + H(+) + holo-[ACP]
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 1, intrinsic regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 2B regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase 3 regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 2B, intrinsic regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Homo sapiens)
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphatase regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase 2 regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase 3, intrinsic regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcineurin regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 1 regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 2A regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcineurin, intrinsic regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 2A, intrinsic regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase 2, intrinsic regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 4 regulator activity
GO:0019888	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 4, intrinsic regulator activity
RHEA:28276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-adenosyl-L-methionine => (S)-S-adenosyl-L-methionine
REACT:R-RNO-2537665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin-1 and -2 bind fibronectin (Rattus norvegicus)
RHEA:39300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)
REACT:R-HSA-1254392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)
REACT:R-DME-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Drosophila melanogaster)
RHEA:22132	skos:prefLabel	"ABC-type maltose transporter"
RHEA:22132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) + phosphate
RHEA:22132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type maltose transporter"
RHEA:22132	skos:altLabel	"maltose-transporting ATPase"
RHEA:35787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	paromamine + UDP-alpha-D-kanosamine = H(+) + kanamycin C + UDP
RHEA:43236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate
REACT:R-CFA-9749971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Canis familiaris)
RHEA:58124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde
REACT:R-MMU-2028692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK4 (p-MST1) by caspase 3 (Mus musculus)
REACT:R-HSA-200952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)
REACT:R-BTA-1605595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Bos taurus)
RHEA:19706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanal + NAD(+) => H(+) + hexadecanoyl-CoA + NADH
RHEA:44154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + phosphate => 1D-myo-inositol 2-phosphate + H2O
REACT:R-BTA-5607747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MALT1 oligomers (Bos taurus)
REACT:R-GGA-380272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plk1-mediated phosphorylation of Nlp (Gallus gallus)
RHEA:13926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine
REACT:R-GGA-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Gallus gallus)
RHEA:22307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + keto-D-fructose <=> 5-dehydro-D-fructose + a ubiquinol
EC:3.2.1.169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein O-GlcNAcase"
EC:3.2.1.169	skos:altLabel	"O-GlcNAc hydrolase"
EC:3.2.1.169	skos:altLabel	"O-GlcNAcase"
EC:3.2.1.169	skos:altLabel	"OGA"
EC:3.2.1.169	skos:prefLabel	"protein O-GlcNAcase"
EC:3.2.1.169	skos:altLabel	"glycoside hydrolase O-GlcNAcase"
REACT:R-MMU-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Mus musculus)
REACT:R-GGA-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)
RHEA:28566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP = 6 AMP + enterobactin + 7 H(+)
GO:0102287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroylhexanoylmethane synthase activity
REACT:R-MMU-8952903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRHL2 hydrolyses poly(ADP-ribose) (Mus musculus)
RHEA:22365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-quinate + NAD(+) => 3-dehydroquinate + H(+) + NADH
REACT:R-HSA-5638004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 binds ARL3:GTP:UNC119B (Homo sapiens)
RHEA:29476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-cubenene + diphosphate
REACT:R-CFA-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Canis familiaris)
REACT:R-GGA-391375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Gallus gallus)
REACT:R-RNO-5423038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Rattus norvegicus)
RHEA:60077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)
RHEA:48544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine
RHEA:48544	skos:prefLabel	"[phosphatase 2A protein]-leucine-carboxy methyltransferase"
RHEA:48544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[phosphatase 2A protein]-leucine-carboxy methyltransferase"
RHEA:48544	skos:altLabel	"leucine carboxy methyltransferase-1"
REACT:R-SSC-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Sus scrofa)
REACT:R-HSA-5654679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR3 (Homo sapiens)
REACT:R-DME-399933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sema3A binds Nrp-1 bound to PlexinA (Drosophila melanogaster)
REACT:R-XTR-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)
RHEA:44272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:46837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CFA-141367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylation of tBID by NMT1 (Canis familiaris)
GO:0004822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoleucine-transfer RNA ligase activity
GO:0004822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-isoleucine:tRNAIle ligase (AMP-forming)
GO:0004822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoleucine translase activity
GO:0004822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoleucyl-transfer RNA synthetase activity
GO:0004822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoleucyl-tRNA synthetase activity
GO:0004822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoleucine-tRNA synthetase activity
GO:0004822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoleucine-tRNA ligase activity
GO:0004822	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoleucyl-transfer ribonucleate synthetase activity
REACT:R-RNO-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Rattus norvegicus)
REACT:R-CEL-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Caenorhabditis elegans)
REACT:R-RNO-389381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gads binds CD28 (Rattus norvegicus)
REACT:R-DRE-8851877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Danio rerio)
RHEA:57578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:48974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + phosphite(in) => ATP + H2O + phosphite(out)
REACT:R-HSA-8874745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Homo sapiens)
REACT:R-CFA-428262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Canis familiaris)
RHEA:70421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + CoA + H(+) => 3,4-dihydroxyphenylacetyl-CoA + H2O
REACT:R-SSC-6786101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4 binds IL4R:JAK2 (Sus scrofa)
REACT:R-CFA-2213239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MHC II alpha beta heterodimer (Canis familiaris)
REACT:R-MMU-4641236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates FZD to potentiate WNT signaling (Mus musculus)
REACT:R-DRE-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Danio rerio)
REACT:R-SCE-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Saccharomyces cerevisiae)
REACT:R-SSC-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Sus scrofa)
RHEA:33224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA
REACT:R-GGA-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Gallus gallus)
REACT:R-SSC-400092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Sus scrofa)
RHEA:11336	skos:altLabel	"16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase"
RHEA:11336	skos:altLabel	"NMT"
RHEA:11336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase"
RHEA:11336	skos:altLabel	"16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase"
RHEA:11336	skos:altLabel	"S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase"
RHEA:11336	skos:prefLabel	"3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase"
RHEA:11336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-3928645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB:NMDAR binds TIAM1 (Homo sapiens)
GO:0047261	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity
GO:0047261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid N-acetylglucosaminyltransferase activity
GO:0047261	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity
GO:0047261	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid acetylglucosaminyltransferase activity
GO:0047261	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxy steroid acetylglucosaminyltransferase activity
REACT:R-DME-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)
REACT:R-BTA-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)
REACT:R-CEL-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Caenorhabditis elegans)
RHEA:46620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
REACT:R-DME-373734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin interacts with Podocin (Drosophila melanogaster)
GO:0004614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglucose mutase activity
GO:0004614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglucomutase activity
GO:0004614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucose 1,6-phosphomutase activity
GO:0004614	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose phosphomutase activity
RHEA:40374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP <=> 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)
GO:0004819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminyl-transfer RNA synthetase activity
GO:0004819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine-tRNA ligase activity
GO:0004819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminyl ribonucleic acid
GO:0004819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine-tRNA synthetase activity
GO:0004819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine translase activity
GO:0004819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminyl-transfer ribonucleate synthetase activity
GO:0004819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine:tRNAGln ligase (AMP-forming)
GO:0004819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlnRS
GO:0004819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaminyl-tRNA synthetase activity
REACT:R-DRE-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Danio rerio)
REACT:R-RNO-2730872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Calcineurin (Rattus norvegicus)
RHEA:37330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-methionyl-L-alanine(out) <=> ADP + H(+) + L-methionyl-L-alanine(in) + phosphate
RHEA:55723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate
RHEA:43764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + chenodeoxycholate + CoA = AMP + chenodeoxycholoyl-CoA + diphosphate
REACT:R-DME-202137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)
RHEA:10306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP] => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP]
EC:1.17.99.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uracil/thymine dehydrogenase"
EC:1.17.99.4	skos:altLabel	"uracil oxidase"
EC:1.17.99.4	skos:altLabel	"uracil-thymine oxidase"
EC:1.17.99.4	skos:prefLabel	"uracil/thymine dehydrogenase"
EC:1.17.99.4	skos:altLabel	"uracil dehydrogenase"
RHEA:45908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroorienticin B + dTDP-beta-L-vancosamine = chloroeremomycin + dTDP + H(+)
RHEA:28783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinylglycine = glycine + L-cysteine
REACT:R-MMU-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Mus musculus)
RHEA:32533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + D-glucose => 4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
REACT:R-CFA-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Canis familiaris)
REACT:R-DME-9727198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B exchanges K+ for H+ (Drosophila melanogaster)
RHEA:12354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + L-xylo-hex-3-ulonolactone => L-gulono-1,4-lactone + O2
REACT:R-DRE-8851899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Danio rerio)
RHEA:42315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [adrenodoxin] <=> NADPH + 2 oxidized [adrenodoxin]
RHEA:65961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + leukotriene C4(out) => ADP + H(+) + leukotriene C4(in) + phosphate
REACT:R-XTR-9664881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Xenopus tropicalis)
REACT:R-SSC-8948800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNKS and TNKS2 PARylate PTEN (Sus scrofa)
REACT:R-XTR-8953398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIR oxygenates quercetin (Xenopus tropicalis)
REACT:R-CEL-427645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A3 cotransports Pi, 2Na+ (Caenorhabditis elegans)
RHEA:15810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => (R)-linalool + diphosphate
REACT:R-BTA-9667456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B bind desmopressin (Bos taurus)
RHEA:17472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]
REACT:R-XTR-3108203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO2,3 (Xenopus tropicalis)
REACT:R-DRE-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Danio rerio)
REACT:R-HSA-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Homo sapiens)
REACT:R-HSA-5691154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HFE binds TFRC dimer (Homo sapiens)
REACT:R-CFA-175987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from AdoMet to PY (Canis familiaris)
REACT:R-CFA-9705794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 binds SRD5A2 inhibitors (Canis familiaris)
RHEA:15030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + NAD(+) => D-mannose + H(+) + NADH
GO:0004598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidylamidoglycolate peptidylamide-lyase activity
GO:0004598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity
GO:0004598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)
GO:0004598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidylamidoglycolate lyase activity
GO:0004598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAL
GO:0004598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HGAD
GO:0004598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-hydroxyglycine amidating dealkylase activity
GO:0004598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGL
RHEA:32571	skos:altLabel	"MIB synthase"
RHEA:32571	skos:prefLabel	"2-methylisoborneol synthase"
RHEA:32571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methylisoborneol synthase"
RHEA:32571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate
RHEA:32571	skos:altLabel	"2-MIB cyclase"
REACT:R-GGA-1067667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R (Gallus gallus)
REACT:R-DRE-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Danio rerio)
RHEA:49337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dihydroxyspheroidene => H2O + spheroiden-2-one
RHEA:37395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-5683801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates BRCA1 (Homo sapiens)
REACT:R-GGA-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Gallus gallus)
RHEA:65453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + hexanoyl-CoA => CoA + ethyl hexanoate
RHEA:54224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin H2)-sn-glycero-3-phosphocholine = 2-(prostaglandin E2)-sn-glycero-3-phosphocholine
EC:3.4.21.100	skos:altLabel	"pseudomonalisin"
EC:3.4.21.100	skos:prefLabel	"sedolisin"
EC:3.4.21.100	skos:altLabel	"sedolysin"
EC:3.4.21.100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sedolisin"
EC:3.4.21.100	skos:altLabel	"Pseudomonas sp. pepstatin-insensitive carboxyl proteinase"
EC:3.4.21.100	skos:altLabel	"pseudomonapepsin"
REACT:R-CEL-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Caenorhabditis elegans)
REACT:R-PFA-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Plasmodium falciparum)
REACT:R-CEL-622325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
REACT:R-DRE-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Danio rerio)
REACT:R-XTR-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Xenopus tropicalis)
REACT:R-CFA-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Canis familiaris)
RHEA:37180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate => (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
RHEA:30108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH
REACT:R-SSC-5660666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBP and p300 binds NF-kB complex (Sus scrofa)
RHEA:35418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose <=> an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP
REACT:R-DDI-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Dictyostelium discoideum)
REACT:R-SSC-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Sus scrofa)
REACT:R-SSC-2395768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPL hydrolyses TGs from mature CMs (Sus scrofa)
REACT:R-DRE-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Danio rerio)
REACT:R-DDI-69600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic degradation of ubiquitinated-Cdc25A (Dictyostelium discoideum)
REACT:R-MMU-549304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal clearance of organic cations (Mus musculus)
REACT:R-HSA-6810843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin binds periplakin (Homo sapiens)
REACT:R-CFA-9035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysS248-MPST:TXN2 dissociates (Canis familiaris)
REACT:R-DRE-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Danio rerio)
RHEA:23815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-neomenthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH
REACT:R-BTA-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Bos taurus)
REACT:R-HSA-140599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)
REACT:R-HSA-9604675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 binds to TACC3 (Homo sapiens)
REACT:R-RNO-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Rattus norvegicus)
RHEA:37605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate
RHEA:56307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + rifampicin <=> 21-phosphorifampicin + AMP + 2 H(+) + phosphate
RHEA:40420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)
REACT:R-CEL-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Caenorhabditis elegans)
RHEA:20795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-lysine + tRNA(Lys) <=> AMP + diphosphate + L-lysyl-tRNA(Lys)
RHEA:54675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-kolavenyl diphosphate + H2O <=> (+)-kolavelool + diphosphate
RHEA:34870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + thiophene-2-carboxylate <=> AMP + diphosphate + thiophene-2-carbonyl-CoA
RHEA:46138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + NADP(+) + pyrrolnitrin => aminopyrrolnitrin + H(+) + NADPH + 2 O2
REACT:R-HSA-9708533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 translocates from the cytosol to the nucleoplasm (Homo sapiens)
REACT:R-RNO-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Rattus norvegicus)
REACT:R-DRE-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Danio rerio)
REACT:R-SSC-3239019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK5 (Sus scrofa)
RHEA:11334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + RNA(n)-3'-adenine ribonucleotide => ATP + RNA(n)
GO:0102065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	patchoulene synthase activity
RHEA:57802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite => 2,3-dinitrotoluene + NADH + O2
RHEA:70442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 <=> a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate
RHEA:36038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH
RHEA:35352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H(+) + NADPH
REACT:R-HSA-918229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
REACT:R-DRE-5654697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
EC:4.1.1.98	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-3-polyprenylbenzoate decarboxylase"
EC:4.1.1.98	skos:altLabel	"3-octaprenyl-4-hydroxybenzoate decarboxylase"
EC:4.1.1.98	skos:altLabel	"4-hydroxy-3-solanesylbenzoate decarboxylase"
EC:4.1.1.98	skos:prefLabel	"4-hydroxy-3-polyprenylbenzoate decarboxylase"
REACT:R-DRE-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Danio rerio)
REACT:R-DDI-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Dictyostelium discoideum)
RHEA:65974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a peptide antigen(out) + ADP + H(+) + phosphate => a peptide antigen(in) + ATP + H2O
RHEA:65439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate
REACT:R-CEL-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)
RHEA:29454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphonate <=> H2 + phosphate
GO:0060001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	minus-end directed microfilament motor activity
GO:0060001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pointed-end directed actin-filament motor activity
GO:0060001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	minus-end directed actin filament motor activity
GO:0060001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	minus-end directed actin-filament motor activity
REACT:R-DRE-9640254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Danio rerio)
RHEA:50923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> chromopyrrolate + H(+) + 2 H2O + NH4(+)
RHEA:66445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-3-one + NADP(+) => (E)-4-hexen-3-one + H(+) + NADPH
GO:0016703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
REACT:R-CFA-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Canis familiaris)
RHEA:42689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide => A + ergothioneine + NH4(+) + pyruvate
REACT:R-MMU-75825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of Cyclin D1 (Mus musculus)
REACT:R-SSC-430158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds VAV (Sus scrofa)
RHEA:17163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopent-4-enoate + benzoate + H(+) => 2,6-dioxo-6-phenylhexa-3-enoate + H2O
REACT:R-DME-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-MMU-9607301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2 binds SOS1 (Mus musculus)
REACT:R-XTR-1112755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds IL6ST (Xenopus tropicalis)
REACT:R-SPO-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)
REACT:R-HSA-9649393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 KD mutants bind trastuzumab (Homo sapiens)
REACT:R-DRE-1112565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Danio rerio)
RHEA:23713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pregnan-21-ol => H(+) + NADPH + pregnan-21-al
REACT:R-CEL-8875540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 recruits CRK,CRKL to MET (Caenorhabditis elegans)
REACT:R-HSA-5610732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI3 (Homo sapiens)
GO:0036428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)
GO:0036428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcobinamide kinase (GTP-specific) activity
RHEA:36370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-alpha-hydroxyglutarate-gamma-lactone + H2O <=> 2-hydroxyglutarate + H(+)
RHEA:65845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + phosphate(in) => ADP(in) + phosphate(out)
REACT:R-DME-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Drosophila melanogaster)
REACT:R-SSC-9018894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Sus scrofa)
RHEA:53232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-5beta-steroid => a 3-oxo-Delta(4)-steroid + AH2
REACT:R-MMU-936947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Mus musculus)
GO:0004919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-9 receptor activity
GO:0004919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-9 receptor activity
GO:0004919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-9R
REACT:R-MMU-9692738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds HRH2 antagonists (Mus musculus)
REACT:R-XTR-1295609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates SPRY2 on Y55 and Y227 (Xenopus tropicalis)
REACT:R-MMU-70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Mus musculus)
GO:0004746	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin synthetase activity
GO:0004746	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heavy riboflavin synthase
GO:0004746	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity
GO:0004746	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavine synthase activity
GO:0004746	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lumazine synthase activity
GO:0004746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin synthase activity
GO:0004746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B2 synthase activity
GO:0004746	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavine synthetase activity
GO:0004746	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	light riboflavin synthase
RHEA:67006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate => a 5'-end triphospho-ribonucleoside in mRNA + H2O
RHEA:32820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromate(in) => chromate(out)
RHEA:16415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein] => (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein]
REACT:R-RNO-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Rattus norvegicus)
RHEA:64207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:35159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol
GO:0043840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity
GO:0043840	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	branched-chain amino acid aminotransferase
GO:0043840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity
GO:0043840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BCAT
GO:0043840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity
RHEA:33008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + tricetin => 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-DME-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Drosophila melanogaster)
RHEA:11574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + FADH2 => FAD + H(+) + H2O + lithocholate
GO:0015495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid:hydrogen symporter activity
GO:0015495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyrate:hydrogen symporter activity
GO:0015495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Homo sapiens)
GO:0015495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid:proton symporter activity
GO:0015495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA:hydrogen symporter activity
GO:0015495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA:proton symporter activity
GO:0015495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyrate:proton symporter activity
GO:0015495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate:proton symporter activity
GO:0015495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate:hydrogen symporter activity
GO:0015495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid permease activity
REACT:R-MMU-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Mus musculus)
REACT:R-HSA-8866105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCPs deglutamylate tubulin (Homo sapiens)
RHEA:25327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphocholine + S-adenosyl-L-homocysteine => N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
RHEA:22524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carotenoid phi-ring synthase"
RHEA:22524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + a carotenoid beta-end derivative = a carotenoid phi-end derivative + 2 AH2
RHEA:22524	skos:prefLabel	"carotenoid phi-ring synthase"
REACT:R-MMU-266310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:spherical HDL complex <=> LCAT + spherical HDL (Mus musculus)
REACT:R-XTR-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Xenopus tropicalis)
REACT:R-XTR-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Xenopus tropicalis)
REACT:R-HSA-2090037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(6) (Homo sapiens)
RHEA:42175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoyl-CoA + AH2 + O2 <=> (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O
RHEA:52831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 <=> (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)
GO:0032547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine deoxyribonucleoside binding
RHEA:10355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetylarylalkylamine + H2O <=> acetate + an aralkylamine
RHEA:23771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + sphing-4-enine <=> an N-acylsphing-4-enine + CoA + H(+)
RHEA:41869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-HSA-8948063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Homo sapiens)
RHEA:48748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threitol + NAD(+) = D-erythrulose + H(+) + NADH
RHEA:48748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-threitol dehydrogenase (NAD(+))"
RHEA:48748	skos:prefLabel	"D-threitol dehydrogenase (NAD(+))"
REACT:R-HSA-9029555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the ABCG8 gene (Homo sapiens)
REACT:R-XTR-211991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclophosphamide is 4-hydroxylated by CYP2B6 (Xenopus tropicalis)
REACT:R-SSC-451347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JNK by DSCAM (Sus scrofa)
RHEA:41675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycerol + ATP <=> 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SPO-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Schizosaccharomyces pombe)
REACT:R-MMU-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Mus musculus)
RHEA:41433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-L-tyrosine + H2O2 => 5-hydroxy-3-methyl-L-tyrosine + H2O
REACT:R-GGA-9757951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
REACT:R-SCE-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Saccharomyces cerevisiae)
REACT:R-CEL-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Caenorhabditis elegans)
RHEA:10163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-iditol + NAD(+) <=> H(+) + keto-L-sorbose + NADH
REACT:R-GGA-433961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 (Gallus gallus)
REACT:R-RNO-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Rattus norvegicus)
REACT:R-SSC-193646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF binding to p75NTR inactivates RHOA (Sus scrofa)
RHEA:52492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Rattus norvegicus)
RHEA:19886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + O2 => (S)-scoulerine + H(+) + H2O2
REACT:R-MMU-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Mus musculus)
REACT:R-GGA-2980720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 binds NEK6/NEK7 in the cytosol (Gallus gallus)
RHEA:10020	skos:altLabel	"saccharopine reductase"
RHEA:10020	skos:prefLabel	"saccharopine dehydrogenase (NADP(+), L-glutamate-forming)"
RHEA:10020	skos:altLabel	"aminoadipic semialdehyde-glutamic reductase"
RHEA:10020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"saccharopine dehydrogenase (NADP(+), L-glutamate-forming)"
RHEA:10020	skos:altLabel	"aminoadipate semialdehyde-glutamate reductase"
RHEA:10020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH
RHEA:10020	skos:altLabel	"aminoadipic semialdehyde-glutamate reductase"
REACT:R-DME-4641129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is ubiquitinated by SMURF2 (Drosophila melanogaster)
RHEA:12176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylethanolamine + S-adenosyl-L-methionine = H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine
RHEA:23876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoaphin aglucone = H2O + xanthoaphin
RHEA:23876	skos:prefLabel	"protoaphin-aglucone dehydratase (cyclizing)"
RHEA:23876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protoaphin-aglucone dehydratase (cyclizing)"
REACT:R-SSC-4420107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHC-transforming protein 2 (Sus scrofa)
RHEA:54464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate
RHEA:55102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxypentanoyl-[ACP] + NADP(+) => 3-oxopentanoyl-[ACP] + H(+) + NADPH
REACT:R-BTA-6799722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 oxidoreductase generates unstable semiquinones (Bos taurus)
RHEA:39566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)
REACT:R-RNO-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Rattus norvegicus)
REACT:R-CEL-445069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-EGFR trans-heterodimerization (Caenorhabditis elegans)
RHEA:32453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-phytoene + 2 diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-MMU-5655835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Mus musculus)
REACT:R-SSC-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Sus scrofa)
REACT:R-SSC-188979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Sus scrofa)
REACT:R-DRE-8983834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Danio rerio)
RHEA:31336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin cytosine dinucleotide
REACT:R-HSA-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Homo sapiens)
REACT:R-BTA-9712210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Bos taurus)
REACT:R-CFA-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Canis familiaris)
RHEA:49488	skos:prefLabel	"GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase"
RHEA:49488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase"
RHEA:49488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)
RHEA:29650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltopentaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotetraose
RHEA:66261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + IC-asc-C7-AMP => AMP + H(+) + IC-asc-C7-CoA
REACT:R-XTR-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Xenopus tropicalis)
RHEA:13398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxohexanoate + H2O + NADP(+) => 2 H(+) + hexanedioate + NADPH
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosylgalactosylglucosylceramide beta-D- activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta3GalNAc-T1
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-3GalNAc-T1 activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	globoside synthase activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	globoside synthetase activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity
GO:0047273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity
GO:0031688	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A2B adenosine receptor ligand
GO:0031688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A2B adenosine receptor binding
REACT:R-CEL-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Caenorhabditis elegans)
RHEA:46206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:28925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-phenylalanine(out) => H(+)(in) + L-phenylalanine(in)
REACT:R-DRE-5653878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Danio rerio)
REACT:R-DME-214880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
REACT:R-XTR-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Xenopus tropicalis)
RHEA:71462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P <=> L-Leu-L-Met-NH2 + substance P(1-9)
RHEA:44522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:12865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methyladenosine + H2O = 1-methyladenine + D-ribose
RHEA:12865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-methyladenosine nucleosidase"
RHEA:12865	skos:prefLabel	"1-methyladenosine nucleosidase"
REACT:R-CFA-159050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Canis familiaris)
GO:0034534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methylnaphthalene hydroxylase activity
REACT:R-HSA-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Homo sapiens)
REACT:R-MMU-5423117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates MeK21-histone H4 (Mus musculus)
REACT:R-MMU-141200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates of PEA (Mus musculus)
REACT:R-DRE-6809309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR6 binds MTMR9 (Danio rerio)
RHEA:13765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H(+)
GO:0033830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity
GO:0033830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity
GO:0033830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity
GO:0033830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Skp1-HyPro GlcNAc-transferase activity
GO:0033830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity
GO:0033830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity
RHEA:13895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + AMP + 2 H(+) => H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate
RHEA:13940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulfobenzoate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD(+) + sulfite
RHEA:67638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dZMP + fumarate => (2S)-2-amino-2'-deoxyadenylo-succinate
RHEA:24047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + O2 <=> 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)
RHEA:33089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-6-naphthoate + chemical entity => cyclic dehypoxanthinylfutalosinate
REACT:R-DRE-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Danio rerio)
RHEA:15140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol 1-phosphate + NAD(+) <=> H(+) + keto-L-tagatose 6-phosphate + NADH
RHEA:41716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine
RHEA:54436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate
REACT:R-CFA-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Canis familiaris)
REACT:R-DME-72185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA polyadenylation (Drosophila melanogaster)
RHEA:67362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-threonine => H2O + L-threonyl-L-threonine
RHEA:18851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:44732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)
RHEA:28090	skos:prefLabel	"UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase"
RHEA:28090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase"
RHEA:28090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
RHEA:28090	skos:altLabel	"UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase"
RHEA:28090	skos:altLabel	"undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase"
REACT:R-CEL-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Caenorhabditis elegans)
REACT:R-XTR-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Xenopus tropicalis)
RHEA:56771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-zeaxanthin + 2 O2 <=> 2 A + all-trans-adonixanthin + 3 H2O
REACT:R-SSC-8848247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD4,5 bind MCFA-CoA and LCFA-CoA (Sus scrofa)
REACT:R-BTA-194689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Bos taurus)
REACT:R-XTR-183126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to surface-associated C3b (Xenopus tropicalis)
REACT:R-BTA-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)
RHEA:18280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thiol + S-adenosyl-L-methionine <=> a methyl thioether + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Danio rerio)
GO:0097509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxanine-DNA glycosylase activity
GO:0097509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxanine DNA N-glycosylase activity
REACT:R-DME-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Drosophila melanogaster)
REACT:R-HSA-9762209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 is phosphorylated at tyrosine 486 (Homo sapiens)
RHEA:57944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b
REACT:R-RNO-5662620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds cadmium (Rattus norvegicus)
REACT:R-XTR-6809521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPIF binds bacteria (Xenopus tropicalis)
REACT:R-DDI-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Dictyostelium discoideum)
GO:0043546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Moco binding
GO:0043546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdopterin cofactor binding
REACT:R-BTA-183002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Bos taurus)
REACT:R-GGA-1980233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Gallus gallus)
RHEA:20745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin D2 => 15-oxoprostaglandin D2 + H(+) + NADPH
REACT:R-CEL-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Caenorhabditis elegans)
RHEA:49909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)
RHEA:69396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]
REACT:R-DDI-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Dictyostelium discoideum)
RHEA:35689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecasphinganine + H(+) + NADPH => NADP(+) + tetradecasphinganine
RHEA:62074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-galactono-1,5-lactone + H(+) + NADPH => D-galactose 6-phosphate + NADP(+)
RHEA:65129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-SSC-3244643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds cyclic GMP-AMP (Sus scrofa)
RHEA:31581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
REACT:R-DME-8948015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Drosophila melanogaster)
RHEA:65748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dodecyl sulfate + O2 = CO2 + dodecanal + H(+) + succinate + sulfate
RHEA:21512	skos:prefLabel	"3,6-anhydro-L-galactonate cycloisomerase"
RHEA:21512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,6-anhydro-L-galactonate cycloisomerase"
RHEA:21512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-L-galactonate = 2-dehydro-3-deoxy-L-galactonate
RHEA:44084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + heptadecanoate = AMP + diphosphate + heptadecanoyl-CoA
REACT:R-PFA-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Plasmodium falciparum)
REACT:R-MMU-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Mus musculus)
REACT:R-RNO-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Rattus norvegicus)
REACT:R-CEL-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Caenorhabditis elegans)
REACT:R-DME-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Drosophila melanogaster)
REACT:R-MMU-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Mus musculus)
REACT:R-RNO-9026007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Rattus norvegicus)
REACT:R-SSC-8944261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIII (Sus scrofa)
REACT:R-XTR-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Xenopus tropicalis)
RHEA:28303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + germacrene C
RHEA:19119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical => dopamine + 2 L-ascorbate + O2
REACT:R-PFA-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Plasmodium falciparum)
GO:0004995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tachykinin receptor activity
REACT:R-SCE-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Saccharomyces cerevisiae)
REACT:R-DRE-1008200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 binds the beta globin locus control region (Danio rerio)
REACT:R-SCE-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Saccharomyces cerevisiae)
REACT:R-XTR-109530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Xenopus tropicalis)
REACT:R-SSC-420127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGRP receptor can bind calcitonin gene-related peptides (Sus scrofa)
RHEA:69880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] => castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:42876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine
REACT:R-CFA-5205682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin promotes the ubiquitination of mitochondrial substrates (Canis familiaris)
REACT:R-BTA-141159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-mediated dimerization of procaspase-8 (Bos taurus)
REACT:R-SSC-372697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binding to p130cas (Sus scrofa)
RHEA:57728	skos:prefLabel	"trans-aconitate decarboxylase"
RHEA:57728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + trans-aconitate = CO2 + itaconate
RHEA:57728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-aconitate decarboxylase"
EC:1.3.5.1	skos:altLabel	"fumarate reductase (menaquinone)"
EC:1.3.5.1	skos:altLabel	"succinate dehydrogenase (quinone)"
EC:1.3.5.1	skos:prefLabel	"succinate dehydrogenase"
EC:1.3.5.1	skos:altLabel	"succinate dehydrogenase (menaquinone)"
EC:1.3.5.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinate dehydrogenase"
EC:1.3.5.1	skos:altLabel	"succinic dehydrogenase"
EC:1.3.5.1	skos:altLabel	"succinate dehydrogenase (ubiquinone)"
REACT:R-RNO-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Rattus norvegicus)
REACT:R-RNO-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Rattus norvegicus)
REACT:R-DRE-1234164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)
RHEA:70989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(in) + n H(+)(out) => beta-alanine(out) + n H(+)(in)
REACT:R-DME-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Drosophila melanogaster)
RHEA:47710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + phosphate => ADP + alpha-D-glucose 1-phosphate + H(+)
REACT:R-DME-374664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of Ezrin (Drosophila melanogaster)
RHEA:59095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n) + sucrose <=> [(1->3)-alpha-D-glucosyl](n+1) + D-fructose
REACT:R-MMU-8956684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH polyubiquitinates TP73 (Mus musculus)
RHEA:50619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + nonan-2-one <=> (3E)-nonen-2-one + H(+) + NADPH
RHEA:60443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl acetate <=> acetate + H(+) + methanol
RHEA:10094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 3'-phosphate + H2O
RHEA:69908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + uridine(out) => 2 Na(+)(in) + uridine(in)
REACT:R-SSC-5624129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LZTFL1 binds the BBSome and prevents its traffic to the cilium (Sus scrofa)
GO:0047890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonone 4-reductase activity
GO:0047890	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity
GO:0047890	skos:prefLabel	"flavanone 4-reductase"
GO:0047890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavanone 4-reductase activity
GO:0047890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavanone 4-reductase"
GO:0047890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + H(+) + NADPH
REACT:R-SSC-8935732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds SIN3A,(SIN3B) co-repressor (Sus scrofa)
REACT:R-DME-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Drosophila melanogaster)
RHEA:36810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + octacosanoyl-CoA <=> 3-oxo-triacontanoyl-CoA + CO2 + CoA
REACT:R-MMU-5607759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIKA2 binds K63polyUb-TRAF6 oligomer (Mus musculus)
RHEA:32969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O
RHEA:40878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2
RHEA:72542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + H2O + NADP(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADPH
RHEA:25445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (1E,4E)-germacrene B + diphosphate
RHEA:14271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1,4-benzosemiquinone + NADP(+) => 2 a quinone + H(+) + NADPH
REACT:R-SSC-8944229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type IX (Sus scrofa)
REACT:R-BTA-5686286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Bos taurus)
REACT:R-SSC-8948228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Sus scrofa)
RHEA:49282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + FAD + H(+) + H2O => FADH2 + O2 + phenol
REACT:R-DRE-8849881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM2 associate with AMPA and NMDA receptors (Danio rerio)
GO:0015434	skos:prefLabel	"ABC-type Cd(2+) transporter"
GO:0015434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type cadmium transporter activity
GO:0015434	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cadmium-transporting ATPase activity
GO:0015434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type Cd(2+) transporter"
GO:0015434	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent cadmium transmembrane transporter activity
GO:0015434	skos:altLabel	"cadmium-transporting ATPase"
GO:0015434	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled cadmium transmembrane transporter activity
GO:0015434	skos:altLabel	"ABC-type cadmium-transporter"
GO:0015434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadmium ABC transporter
REACT:R-MMU-71260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Mus musculus)
REACT:R-BTA-8849908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM4 binds flotillin-1 (Bos taurus)
RHEA:71242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH <=> 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)
RHEA:34847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromonapterin + H(+) + NADPH = 5,6,7,8-tetrahydromonapterin + NADP(+)
RHEA:34847	skos:altLabel	"H2-MPt reductase"
RHEA:34847	skos:prefLabel	"dihydromonapterin reductase"
RHEA:34847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydromonapterin reductase"
RHEA:60253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + NADP(+) => acryloyl-CoA + CO2 + NADPH
GO:0043211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate-transporting ATPase activity
GO:0043211	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carbohydrate ABC transporter
GO:0043211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type carbohydrate transporter activity
GO:0043211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent carbohydrate transmembrane transporter activity
GO:0043211	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-coupled carbohydrate transmembrane transporter activity
REACT:R-DRE-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Danio rerio)
REACT:R-BTA-380901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked serotonin loaded synaptic vesicle (Bos taurus)
RHEA:40106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propanoyl-CoA <=> CoA + H(+) + propanoate
REACT:R-GGA-199161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fc gamma receptors interact with antigen-bound IgG (Gallus gallus)
REACT:R-BTA-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Bos taurus)
REACT:R-BTA-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Bos taurus)
RHEA:37409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
RHEA:29704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine(in) => L-valine(out)
GO:0010012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 22-alpha hydroxylase activity
RHEA:56427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:63203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10bS,4aR)-noroxomaritidine + H(+) + NADPH <=> (10bS,4aR)-oxomaritidine + NADP(+)
GO:0030699	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)
GO:0030699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine reductase activity
REACT:R-MMU-2065549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Mus musculus)
REACT:R-GGA-5205649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 links damaged mitochondria to LC3 (Gallus gallus)
REACT:R-SSC-482770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet secretory granule components (Sus scrofa)
REACT:R-HSA-141026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor Va to factor Vi intermediate form (Homo sapiens)
REACT:R-RNO-873922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 by JAK kinases (Rattus norvegicus)
RHEA:16441	skos:altLabel	"peptidoglutaminase II"
RHEA:16441	skos:prefLabel	"protein-glutamine glutaminase"
RHEA:16441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-glutamine glutaminase"
RHEA:16441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)
RHEA:16441	skos:altLabel	"Glutaminylpeptide glutaminase"
RHEA:14609	skos:prefLabel	"sorbose reductase"
RHEA:14609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sorbose reductase"
RHEA:14609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + NADP(+) = H(+) + keto-L-sorbose + NADPH
REACT:R-HSA-8936676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)
RHEA:44001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 => 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate
RHEA:23306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + tropate + tropine => atropine + H2O
REACT:R-CFA-432712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Canis familiaris)
RHEA:23387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose <=> beta-D-glucosyl-(1->4)-D-mannopyranose
REACT:R-SSC-2473596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP15 (Sus scrofa)
RHEA:42312	skos:altLabel	"nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase"
RHEA:42312	skos:prefLabel	"adrenodoxin-NADP(+) reductase"
RHEA:42312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adrenodoxin-NADP(+) reductase"
RHEA:42312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin]
RHEA:42312	skos:altLabel	"adrenodoxin reductase"
REACT:R-DRE-9036307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPER:Heterotrimeric G-protein Gs binds ESTG (Danio rerio)
GO:0016655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
GO:0016655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0016655	skos:prefLabel	"With a quinone or similar compound as acceptor"
GO:0016655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
RHEA:32295	skos:altLabel	"presqualene-diphosphate synthase"
RHEA:32295	skos:altLabel	"presqualene synthase"
RHEA:32295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"squalene synthase"
RHEA:32295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH = 2 diphosphate + NADP(+) + squalene
RHEA:32295	skos:altLabel	"squalene synthetase"
RHEA:32295	skos:prefLabel	"squalene synthase"
RHEA:32295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate + H(+) + NADH = 2 diphosphate + NAD(+) + squalene
RHEA:32295	skos:altLabel	"farnesyl-diphosphate farnesyltransferase"
RHEA:32295	skos:altLabel	"farnesyltransferase"
EC:3.4.24.41	skos:altLabel	"Crotalus atrox metalloendopeptidase b"
EC:3.4.24.41	skos:prefLabel	"atrolysin B"
EC:3.4.24.41	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"atrolysin B"
EC:3.4.24.41	skos:altLabel	"hemorrhagic toxin b"
EC:3.4.24.41	skos:altLabel	"Ht-b"
REACT:R-DME-5671970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CIT binds KIF14 and PRC1 (Drosophila melanogaster)
RHEA:68834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-nerolidol + diphosphate => (2Z,6Z)-farnesyl diphosphate + H2O
RHEA:59298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => an N-acylglycine + 2 L-ascorbate + O2
REACT:R-BTA-3782655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC10 deacetylates histone (Bos taurus)
REACT:R-SSC-9023626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Sus scrofa)
RHEA:62173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylethanolamine phosphate + H2O => an N-acylethanolamine + phosphate
REACT:R-RNO-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Rattus norvegicus)
RHEA:14799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+) => 2-dehydro-3-deoxy-D-gluconate + ATP
RHEA:50580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]
REACT:R-BTA-909552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 at Ser727 (Bos taurus)
REACT:R-CFA-9749647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES2 hydrolyzes ASA- (Canis familiaris)
RHEA:40859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + FAD + H(+) = (2E,9Z)-hexadecadienoyl-CoA + FADH2
REACT:R-DRE-158468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates PARA to PARA-SO4 (Danio rerio)
RHEA:39205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADPH
REACT:R-XTR-173542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 ubiquitinates SMAD2 (Xenopus tropicalis)
REACT:R-CFA-8950522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1:p-STAT4 translocates to the nucleus (Canis familiaris)
RHEA:15160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)
REACT:R-CFA-202722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD48 binds CD244 (Canis familiaris)
REACT:R-HSA-140777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Homo sapiens)
REACT:R-DRE-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Danio rerio)
REACT:R-CEL-6806974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET dimers autophosphorylate (Caenorhabditis elegans)
REACT:R-MMU-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Mus musculus)
RHEA:34811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetrahydrocurcumin = dihydrocurcumin + H(+) + NADPH
GO:0052933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol dehydrogenase (cytochrome c(L)) activity
GO:0052933	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methanol dehydrogenase activity
GO:0052933	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ethanol cytochrome-c oxidoreductase activity
GO:0052933	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methanol ferricytochrome-c oxidoreductase activity
GO:0052933	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	2-chloroethanol cytochrome-c oxidoreductase activity
GO:0052933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol:cytochrome c(L) oxidoreductase activity
REACT:R-BTA-5649883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB-mediated DNA strand displacement synthesis (Bos taurus)
REACT:R-RNO-3640862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase binds AXIN (Rattus norvegicus)
RHEA:72526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine + S-adenosyl-L-methionine <=> 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Gallus gallus)
REACT:R-DDI-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Dictyostelium discoideum)
RHEA:60190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2
RHEA:44215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxytetradecanoate + ATP + CoA <=> 3-hydroxytetradecanoyl-CoA + AMP + diphosphate
REACT:R-CFA-173723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C8 binds C5b:C6:C7 (Canis familiaris)
RHEA:50641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)ethylmalate => 3-(2-methylsulfanyl)ethylmalate
RHEA:29303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + succinate(in) = 2 H(+)(out) + succinate(out)
REACT:R-RNO-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
GO:0010491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP:arabinose-1-phosphate uridylyltransferase activity
RHEA:40805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-L-galactonate + 2 H(+) + NADPH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+)
RHEA:45767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate 4-semialdehyde + NAD(+) <=> 2 H(+) + L-aspartate + NADH
RHEA:60901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in RNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine
RHEA:69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + serotonin
REACT:R-XTR-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Xenopus tropicalis)
REACT:R-MMU-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Mus musculus)
RHEA:71747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + L-2-aminoadipate(in) = 2-oxoglutarate(in) + L-2-aminoadipate(out)
RHEA:18146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose => ADP + beta-D-fructose 1-phosphate + H(+)
REACT:R-DRE-8964605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Danio rerio)
REACT:R-SCE-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Saccharomyces cerevisiae)
RHEA:57039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->6)-alpha-D-glucosyl](n) + sucrose <=> (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose
REACT:R-SSC-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Sus scrofa)
REACT:R-HSA-6800279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the PIDD1 gene (Homo sapiens)
REACT:R-SSC-1504193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL is degraded by the proteasome (Sus scrofa)
RHEA:57497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylcitrate => 2-methyl-cis-aconitate + H2O
REACT:R-RNO-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Rattus norvegicus)
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-Q6 oxidoreductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	complex I (NADH:Q1 oxidoreductase) activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH dehydrogenase (ubiquinone) activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial electron transport complex 1 activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH coenzyme Q1 reductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquinone reductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-ubiquinone-1 reductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	complex I (electron transport chain) activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	electron transfer complex I activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	complex I (mitochondrial electron transport) activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPNH-ubiquinone reductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-ubiquinone oxidoreductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme Q reductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-ubiquinone reductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type 1 dehydrogenase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-coenzyme Q oxidoreductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial electron transport complex I activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-CoQ oxidoreductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:ubiquinone oxidoreductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-CoQ reductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-coenzyme Q reductase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	complex 1 dehydrogenase activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:ubiquinone oxidoreductase complex activity
GO:0008137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPNH-coenzyme Q reductase activity
REACT:R-GGA-419145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate (Gallus gallus)
RHEA:62862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O => acetyl-CoA + 7 H(+) + 7 malonyl-CoA
REACT:R-HSA-447252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB1:TYK2 binds IL12RB2:JAK2 (Homo sapiens)
RHEA:30201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate
REACT:R-HSA-9674542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT1,3,5 dimerize (Homo sapiens)
RHEA:28023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[ACP] + octanoate => AMP + diphosphate + octanoyl-[ACP]
REACT:R-SSC-5252079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Sus scrofa)
REACT:R-DRE-109539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Danio rerio)
REACT:R-CEL-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
RHEA:39621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH
REACT:R-HSA-382054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binds to extracellular matrix proteins (Homo sapiens)
REACT:R-SSC-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Sus scrofa)
REACT:R-HSA-6799418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the TP53INP1 gene (Homo sapiens)
REACT:R-XTR-5678315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Xenopus tropicalis)
GO:0047288	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase activity
GO:0047288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monosialoganglioside sialyltransferase activity
REACT:R-CFA-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Canis familiaris)
RHEA:33850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + tetracosanoate
RHEA:64874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + glycolaldehyde => D-ribulose 1-phosphate
REACT:R-SSC-77301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Sus scrofa)
RHEA:70236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside
REACT:R-HSA-264848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoA-I binds to CUBN:AMN (Homo sapiens)
GO:0000170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine hydroxylase activity
GO:0000170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Homo sapiens)
RHEA:17589	skos:prefLabel	"alanopine dehydrogenase"
RHEA:17589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alanopine dehydrogenase"
RHEA:17589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2'-iminodipropanoate + H2O + NAD(+) = H(+) + L-alanine + NADH + pyruvate
REACT:R-DME-5654148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR3 (Drosophila melanogaster)
REACT:R-SSC-983145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Sus scrofa)
GO:0004979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-endorphin receptor activity
GO:0004979	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mu-opioid receptor activity
RHEA:53063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + UDP-alpha-D-glucuronate <=> estrone 4-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-MMU-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Mus musculus)
REACT:R-BTA-5665802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Bos taurus)
REACT:R-HSA-444476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPRL2 receptor binds a wide range of ligands (Homo sapiens)
REACT:R-DRE-8938217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SWI/SNF complex (Danio rerio)
REACT:R-CFA-375160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 binds to ATP (Canis familiaris)
REACT:R-CFA-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Canis familiaris)
GO:0047621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylpyruvate hydrolase activity
GO:0047621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-acylpyruvate acylhydrolase activity
REACT:R-XTR-159733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor X to factor X (Xenopus tropicalis)
REACT:R-RNO-388468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR1A,B (Rattus norvegicus)
REACT:R-PFA-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Plasmodium falciparum)
RHEA:62316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylate + UDP-alpha-D-glucose = 1-O-salicyl-beta-D-glucose + UDP
REACT:R-RNO-210271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and MDL-1 (Rattus norvegicus)
REACT:R-CFA-158766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Canis familiaris)
RHEA:58698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide => NADPH + O2 + rifampicin
GO:0052636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinosyl transferase activity
GO:0052636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinosyltransferase activity
RHEA:62813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 monapinone A + O2 => 2 dinapinone A + 2 H2O
REACT:R-HSA-8849082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 stimulates RHOA GTPase activity (Homo sapiens)
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	LSPas binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial heavy strand promoter sense binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	LSP coding strand binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitochondrial RNA polymerase core promoter sequence-specific DNA binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitochondrial RNA polymerase regulatory region DNA binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	HSPas binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitochondrial proximal promoter sequence-specific DNA binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	HSPs binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial promoter sequence-specific DNA binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	LSP non-coding strand binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial light strand promoter sense binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	LSPs binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	HSP non-coding strand binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	HSP coding strand binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial heavy strand promoter anti-sense binding
GO:0001018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial light strand promoter anti-sense binding
REACT:R-BTA-5676599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF trimer binds BAFFR (Bos taurus)
REACT:R-DRE-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Danio rerio)
RHEA:10151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	blasticidin S + H(+) + H2O <=> deaminohydroxyblasticidin S + NH4(+)
GO:0035033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone deacetylase regulator activity
REACT:R-CFA-983696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Immunoglobulin of the BCR binds antigen (Canis familiaris)
REACT:R-CFA-8874206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L3 (Canis familiaris)
REACT:R-SSC-6799761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds PPP1R13L (Sus scrofa)
REACT:R-DME-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Drosophila melanogaster)
REACT:R-MMU-6809006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
REACT:R-GGA-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Gallus gallus)
REACT:R-CFA-71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Canis familiaris)
REACT:R-DRE-994137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Danio rerio)
REACT:R-XTR-2022851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfer GlcNAc to the heparan chain (Xenopus tropicalis)
RHEA:71556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-C(alpha)-glycyl-dTMP in DNA + H(+) => 5-aminoethyl-dUMP in DNA + CO2
REACT:R-CFA-2230938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin:Haptoglobin:CD163 is endocytosed (Canis familiaris)
REACT:R-SSC-9679029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds HCQ (Sus scrofa)
REACT:R-XTR-1855225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Xenopus tropicalis)
REACT:R-HSA-190065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TrkA receptor internalizes to endosomes (Homo sapiens)
RHEA:48360	skos:altLabel	"P450SPalpha"
RHEA:48360	skos:altLabel	"CYP152A1"
RHEA:48360	skos:altLabel	"P450 peroxygenase"
RHEA:48360	skos:prefLabel	"fatty-acid peroxygenase"
RHEA:48360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty-acid peroxygenase"
RHEA:48360	skos:altLabel	"fatty acid hydroxylase"
RHEA:48360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + H2O2 = a 2-hydroxy fatty acid + H2O
RHEA:43518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-5-(dihydroxymethyl)furan => 2-carboxy-5-formylfuran + H2O
REACT:R-DME-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Drosophila melanogaster)
REACT:R-CEL-432909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Plectin with Integrin beta 4 (Caenorhabditis elegans)
REACT:R-DRE-8853774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Danio rerio)
REACT:R-MMU-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Mus musculus)
RHEA:49117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NADP(+)
REACT:R-BTA-5577213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)
REACT:R-HSA-9007605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 gene expression is inhibited by E2F6 (Homo sapiens)
REACT:R-SSC-8944247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VI (Sus scrofa)
REACT:R-RNO-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Rattus norvegicus)
REACT:R-MMU-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Mus musculus)
REACT:R-DME-1604731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP3 (Drosophila melanogaster)
REACT:R-MMU-446868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Interleukin 1 receptor complex binds Tollip (Mus musculus)
GO:0102999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity
REACT:R-DRE-4754187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Danio rerio)
RHEA:54512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate
RHEA:54512	skos:prefLabel	"9,13-epoxylabda-14-ene synthase"
RHEA:54512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"9,13-epoxylabda-14-ene synthase"
REACT:R-HSA-5661125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2sR4-HIST1H4 (Homo sapiens)
RHEA:52208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-PFA-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Plasmodium falciparum)
REACT:R-SSC-177936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Sus scrofa)
RHEA:30373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-geosmin + acetone => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O
RHEA:39014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol(in) <=> a triacyl-sn-glycerol(out)
REACT:R-RNO-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Rattus norvegicus)
REACT:R-MMU-1564120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII degradation by MMP1,2,3 (Mus musculus)
RHEA:40755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate
REACT:R-BTA-168933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of phosphorylated IRF3/IRF7 (Bos taurus)
RHEA:67755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-SSC-5218811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO binds CRK (Sus scrofa)
RHEA:61684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycero-2-phosphocholine + H2O = glycerol + H(+) + phosphocholine
REACT:R-DME-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Drosophila melanogaster)
REACT:R-SSC-2176491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L binds phosphorylated linker region of SMAD2/3 (Sus scrofa)
RHEA:46110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2
RHEA:42405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lactose 6-phosphate => beta-D-glucose + D-galactose 6-phosphate
RHEA:65444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + hexan-1-ol = CoA + hexyl butanoate
GO:0047132	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrobenzophenanthridine:oxygen oxidoreductase activity
GO:0047132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrobenzophenanthridine oxidase activity
REACT:R-HSA-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Homo sapiens)
REACT:R-BTA-8963864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN dissociates from 25(OH)D (Bos taurus)
RHEA:33471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol
REACT:R-DME-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Drosophila melanogaster)
REACT:R-DME-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Drosophila melanogaster)
RHEA:65042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin
REACT:R-CFA-375395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5a receptor binds C5a anaphylatoxin (Canis familiaris)
REACT:R-CEL-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Caenorhabditis elegans)
REACT:R-GGA-379048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)
RHEA:69878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-158164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Mus musculus)
EC:3.8.1.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"haloalkane dehalogenase"
EC:3.8.1.5	skos:altLabel	"1-chlorohexane halidohydrolase"
EC:3.8.1.5	skos:prefLabel	"haloalkane dehalogenase"
REACT:R-BTA-8942575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Bos taurus)
RHEA:51012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacyl-sn-glycero-3-phosphocholine + H2O = a monoacylglycerol + H(+) + phosphocholine
REACT:R-GGA-6793666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the nucleus (Gallus gallus)
REACT:R-RNO-9724753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds anti-fibrinolytics (Rattus norvegicus)
REACT:R-DDI-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)
REACT:R-HSA-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Homo sapiens)
GO:0018543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-nitroso-6-nitrotoluene reductase activity
REACT:R-MMU-9647660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds PIPs (Mus musculus)
RHEA:71416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) => 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)
REACT:R-BTA-983427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of peptide bound class I MHC on cell surface (Bos taurus)
RHEA:62970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + pyruvate => (R)-lactate + NADP(+)
REACT:R-DME-5633040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Drosophila melanogaster)
REACT:R-RNO-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Rattus norvegicus)
GO:0016913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	follicle stimulating hormone activity
GO:0016913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	follicle-stimulating hormone activity
GO:0016913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	follitropin activity
GO:0016913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FSH activity
REACT:R-CFA-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
RHEA:45376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine
REACT:R-HSA-9681674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement (Homo sapiens)
REACT:R-DME-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Drosophila melanogaster)
RHEA:48116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
RHEA:48116	skos:prefLabel	"type IV protein arginine methyltransferase"
RHEA:48116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"type IV protein arginine methyltransferase"
REACT:R-SSC-5694563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD10 hydrolyses MPAG (Sus scrofa)
REACT:R-HSA-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Homo sapiens)
RHEA:36246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + NADP(+) + trans-anol <=> NADPH + trans-coumaryl acetate
RHEA:46672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldosterone + H(+) + NADPH = 5beta-dihydroaldosterone + NADP(+)
REACT:R-CEL-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Caenorhabditis elegans)
RHEA:69727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + ATP + H(+) = diphosphate + phenylacetyl-AMP
REACT:R-BTA-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Bos taurus)
GO:0046932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-transporting two-sector ATPase activity
GO:0046932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-translocating F-type ATPase activity
GO:0046932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-transporting ATP synthase activity, rotational mechanism
REACT:R-RNO-446894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)
REACT:R-XTR-1295622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds CBL (Xenopus tropicalis)
RHEA:55299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + hexadecanoyl-CoA <=> 13-cis-retinyl hexadecanoate + CoA
RHEA:10789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + ATP => 6-phospho-2-dehydro-D-gluconate + ADP + H(+)
RHEA:13081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin amide + H2O = biotin + NH4(+)
RHEA:13081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biotinidase"
RHEA:13081	skos:altLabel	"biotinase"
RHEA:13081	skos:prefLabel	"biotinidase"
RHEA:25869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1),N(12)-diacetylspermine + O2 => 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine
REACT:R-DRE-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Danio rerio)
RHEA:45916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-GGA-8865454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX3 (Gallus gallus)
REACT:R-DME-2176491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L binds phosphorylated linker region of SMAD2/3 (Drosophila melanogaster)
RHEA:65800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O = a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine
REACT:R-RNO-159194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)
RHEA:22482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitroquinoline N-oxide + 2 H(+) + 2 NADH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+)
REACT:R-XTR-9679029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds HCQ (Xenopus tropicalis)
REACT:R-MMU-4568863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RAD52 with SUMO1 (Mus musculus)
RHEA:68957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + scopoletin => H(+) + S-adenosyl-L-homocysteine + scoparone
RHEA:24204	skos:prefLabel	"sulfoacetaldehyde acetyltransferase"
RHEA:24204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + H(+) + sulfite = phosphate + sulfoacetaldehyde
RHEA:24204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfoacetaldehyde acetyltransferase"
REACT:R-HSA-5661121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Homo sapiens)
REACT:R-RNO-5690785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds Ub-HCFC1 (Rattus norvegicus)
REACT:R-RNO-3371385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α is cleaved by ADAM17 (TACE) (Rattus norvegicus)
REACT:R-SSC-1306876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 activation by small molecules (Sus scrofa)
REACT:R-DRE-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Danio rerio)
RHEA:42265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + octanoyl-CoA => 3-oxodecanoyl-[ACP] + CO2 + CoA
REACT:R-BTA-4085217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Bos taurus)
REACT:R-BTA-8848215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Bos taurus)
RHEA:47591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) <=> CMP + ganglioside GQ1c (d18:1(4E)) + H(+)
RHEA:35450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S)-averantin + NADP(+) <=> H(+) + NADPH + norsolorinic acid
RHEA:28702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mn(2+)(in) <=> Mn(2+)(out)
REACT:R-CEL-8949661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Caenorhabditis elegans)
RHEA:29889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-lysine(in) + phosphate => ATP + H2O + L-lysine(out)
RHEA:20220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + trimethylamine N-oxide <=> dimethylamine + formaldehyde
REACT:R-DDI-744231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-GlcNAc for UMP (Dictyostelium discoideum)
RHEA:38960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + O2 => a (2E)-enoyl-CoA + H2O2
REACT:R-CEL-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Caenorhabditis elegans)
REACT:R-GGA-77587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Replication Dependent Histone mRNA with the NPC (Gallus gallus)
RHEA:44918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH
RHEA:13274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol => 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SSC-210283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and PLC gamma1 (Sus scrofa)
EC:3.4.22.36	skos:altLabel	"interleukin 1beta-converting endopeptidase"
EC:3.4.22.36	skos:altLabel	"interleukin 1beta converting enzyme"
EC:3.4.22.36	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-1"
EC:3.4.22.36	skos:altLabel	"interleukin-1 beta convertase precursor"
EC:3.4.22.36	skos:altLabel	"interleukin-1beta convertase"
EC:3.4.22.36	skos:altLabel	"prointerleukin 1beta protease"
EC:3.4.22.36	skos:prefLabel	"caspase-1"
EC:3.4.22.36	skos:altLabel	"pro-interleukin 1beta proteinase"
RHEA:43567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine <=> [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate
REACT:R-HSA-3322422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits SMARCA4 (Homo sapiens)
REACT:R-DDI-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Dictyostelium discoideum)
REACT:R-BTA-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Bos taurus)
REACT:R-HSA-9623355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1-dependent CCND1 expression (Homo sapiens)
REACT:R-SSC-212222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 recruits DNA methyltransferases (Sus scrofa)
REACT:R-RNO-2128994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Rattus norvegicus)
RHEA:34679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + methylphosphonate = adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate
RHEA:34679	skos:prefLabel	"alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase"
RHEA:34679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase"
REACT:R-RNO-4641236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates FZD to potentiate WNT signaling (Rattus norvegicus)
RHEA:13470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + thymine => 5-methylbarbiturate + AH2 + H(+)
REACT:R-GGA-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Gallus gallus)
GO:0102965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol-forming fatty acyl-CoA reductase activity
REACT:R-CEL-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Caenorhabditis elegans)
REACT:R-SSC-2267372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Sus scrofa)
REACT:R-SCE-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Saccharomyces cerevisiae)
REACT:R-CFA-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Canis familiaris)
REACT:R-BTA-9692809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the ER membrane (Bos taurus)
RHEA:37747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:46783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Drosophila melanogaster)
REACT:R-XTR-9623384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-agonists bind ADRA1A,B,D (Xenopus tropicalis)
GO:0004130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	apocytochrome c peroxidase activity
GO:0004130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c-H2O oxidoreductase activity
GO:0004130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mesocytochrome c peroxidase cyanate
GO:0004130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity
GO:0004130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c-551 peroxidase activity
GO:0004130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome peroxidase activity
GO:0004130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mesocytochrome c peroxidase cyanide
GO:0004130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome-c peroxidase activity
GO:0004130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mesocytochrome c peroxidase azide
GO:0004130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c peroxidase activity
REACT:R-GGA-3371554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 acetylation at Lys80 (Gallus gallus)
RHEA:46747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate <=> ADP + carboxyphosphate
RHEA:66675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) <=> 5,7-dihydroxy-4-methylphthalide + H2O
REACT:R-RNO-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Rattus norvegicus)
REACT:R-CFA-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Canis familiaris)
REACT:R-DME-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Drosophila melanogaster)
RHEA:30247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 4 hnu + 2 plastoquinone-9 = O2 + 2 plastoquinol-9
RHEA:36435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)
REACT:R-SSC-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Sus scrofa)
RHEA:65896	skos:prefLabel	"kynurenine--glyoxylate transaminase"
RHEA:65896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kynurenine--glyoxylate transaminase"
RHEA:65896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-kynurenine = glycine + H2O + kynurenate
RHEA:65896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + glyoxylate = glycine + H2O + xanthurenate
RHEA:65896	skos:altLabel	"kynurenine--glyoxylate aminotransferase"
REACT:R-SSC-5696119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Sus scrofa)
REACT:R-DDI-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Dictyostelium discoideum)
RHEA:32702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphate
RHEA:55766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol => 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O
RHEA:39925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-octadecyl-sn-glycero-3-phosphocholine + H2O
RHEA:30202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-DRE-6808496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)
REACT:R-SSC-997311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of TYK2 by PTP1B (Sus scrofa)
RHEA:35944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brevianamide F + dimethylallyl diphosphate => deoxybrevianamide E + diphosphate
RHEA:41452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-1-naphthoate + H(+) + NADPH + O2 = 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)
RHEA:41452	skos:prefLabel	"5-methyl-1-naphthoate 3-hydroxylase"
RHEA:41452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-methyl-1-naphthoate 3-hydroxylase"
REACT:R-MMU-390593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Mus musculus)
REACT:R-CFA-9008258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 binds ESR1:estrogen:TFGA gene (Canis familiaris)
RHEA:44499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine <=> 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine
REACT:R-HSA-9660828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2B:Ade-Rib binds heterometric G-protein Gs (Homo sapiens)
REACT:R-SSC-6805943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A1 binds TLR4:LY96 (Sus scrofa)
REACT:R-DDI-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Dictyostelium discoideum)
RHEA:38378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacterioruberin <=> bisanhydrobacterioruberin + 2 H2O
REACT:R-SCE-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Saccharomyces cerevisiae)
RHEA:56267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
RHEA:45575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannuronosyl](n) <=> [alginate](n)
REACT:R-XTR-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Xenopus tropicalis)
REACT:R-MMU-162730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Mus musculus)
REACT:R-RNO-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Rattus norvegicus)
REACT:R-HSA-428609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type I Na+-coupled phosphate co-transport (Homo sapiens)
REACT:R-DDI-8950780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 binds p-Y693-STAT4 (Dictyostelium discoideum)
GO:0052756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitobiose phosphorylase activity
REACT:R-HSA-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Homo sapiens)
GO:0031817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y8 nucleotide receptor binding
GO:0031817	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P2Y8 nucleotide receptor ligand
REACT:R-SSC-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Sus scrofa)
REACT:R-HSA-9678737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR1:TYK2 binds TYK2 inhibitors (Homo sapiens)
RHEA:18901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(alpha)-benzyloxycarbonylleucine hydrolase"
RHEA:18901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-benzyloxycarbonyl-L-leucine = benzyl alcohol + CO2 + L-leucine
RHEA:18901	skos:prefLabel	"N(alpha)-benzyloxycarbonylleucine hydrolase"
REACT:R-BTA-2160892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Bos taurus)
RHEA:68755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] <=> alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]
REACT:R-DME-996755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFPM proteins bind GATA proteins (Drosophila melanogaster)
RHEA:56325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] => 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]
RHEA:44984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 3-methylbutanoyl-CoA = CoA + O-3-methylbutanoyl-(R)-carnitine
RHEA:23094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylamine + N-isopropylammelide => H(+) + H2O + hydroxyatrazine
REACT:R-BTA-70679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 oxidises L-GluSS to Glu (Bos taurus)
REACT:R-GGA-9008928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Gallus gallus)
RHEA:72807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(out) = L-histidine(in)
GO:0102832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	verbascose galactinol:ajugose galactosyltransferase activity
RHEA:24379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
RHEA:60226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2
RHEA:11963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate
REACT:R-DDI-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Dictyostelium discoideum)
REACT:R-DRE-5635865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 dissociates from ub-PTCH1 (Danio rerio)
REACT:R-BTA-9036727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAA hydrolyzes lysosomal glycogen (Bos taurus)
RHEA:64322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + cholesterol
REACT:R-CFA-1168644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Canis familiaris)
EC:1.17.98.2	skos:prefLabel	"bacteriochlorophyllide c C-7(1)-hydroxylase"
EC:1.17.98.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacteriochlorophyllide c C-7(1)-hydroxylase"
REACT:R-DRE-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Danio rerio)
RHEA:65632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + tetracosanoyl-CoA = an N-tetracosanoyl-sphingoid base + CoA + H(+)
RHEA:70530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acyl-3-oxosphinganine + NADH <=> an N-acylsphinganine + NAD(+)
REACT:R-HSA-9685906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyadenylation of SARS-CoV-1 subgenomic mRNAs (plus strand) (Homo sapiens)
REACT:R-CFA-8876191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 GEFs exchange GTP for GDP on RAB9 (Canis familiaris)
GO:0050521	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glucan,water dikinase activity
GO:0050521	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GWD
GO:0050521	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:alpha-glucan, water phosphotransferase activity
GO:0050521	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	starch-related R1 protein activity
GO:0050521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-glucan, water dikinase activity
GO:0050521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-glucan, water dikinase activity
REACT:R-DRE-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Danio rerio)
RHEA:63108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxy-ilicicolin A epoxide = ascofuranol
REACT:R-HSA-391375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)
RHEA:58240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] = ADP-D-ribose + L-cysteinyl-[protein]
RHEA:61097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol dehydrogenase activity
GO:0102354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH
REACT:R-BTA-114254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS binds to APAF1 (Bos taurus)
RHEA:20427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-oxalosuccinate + ADP + H(+) + phosphate => 2-oxoglutarate + ATP + hydrogencarbonate
REACT:R-DDI-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Dictyostelium discoideum)
RHEA:48075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + H2O <=> ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate
REACT:R-DRE-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Danio rerio)
REACT:R-RNO-9013108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOC (Rattus norvegicus)
REACT:R-HSA-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Homo sapiens)
REACT:R-SSC-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Sus scrofa)
RHEA:70394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + eicosanoyl-CoA <=> CoA + H(+) + N-eicosanoyl-3-oxosphinganine
REACT:R-DRE-5658424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Danio rerio)
REACT:R-MMU-140777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Mus musculus)
RHEA:64067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-pseudoephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
REACT:R-DRE-8981534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin dimer:KIRREL binds FYN (Danio rerio)
REACT:R-XTR-8964271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in PIP3:BTK:G beta-gamma complex is activated (Xenopus tropicalis)
RHEA:27535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (3R,6E)-nerolidol + diphosphate
REACT:R-DME-8953917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Drosophila melanogaster)
RHEA:54119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + pseudolaratriene
RHEA:22784	skos:prefLabel	"phosphosulfolactate synthase"
RHEA:22784	skos:altLabel	"PSL synthase"
RHEA:22784	skos:altLabel	"(2R)-phospho-3-sulfolactate synthase"
RHEA:22784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphosulfolactate synthase"
RHEA:22784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-O-phospho-3-sulfolactate = H(+) + phosphoenolpyruvate + sulfite
REACT:R-RNO-5213466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is phosphorylated (Rattus norvegicus)
REACT:R-HSA-1606602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Homo sapiens)
REACT:R-SPO-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Schizosaccharomyces pombe)
REACT:R-RNO-8950387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX binds EBI3 (Rattus norvegicus)
REACT:R-SPO-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Schizosaccharomyces pombe)
RHEA:72106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-propanoyl-(R)-carnitine(out) <=> Na(+)(in) + O-propanoyl-(R)-carnitine(in)
GO:0018837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity
RHEA:21510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + retinol => all-trans-retinyl hexadecanoate + H2O
REACT:R-RNO-2203516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-1-Microglobulin is cleaved (Rattus norvegicus)
REACT:R-HSA-8866551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
REACT:R-BTA-374331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bradykinin receptors B1 and B2 bind to bradykinin (Bos taurus)
REACT:R-XTR-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)
GO:0043914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH:sulphur oxidoreductase activity
GO:0043914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)H sulfur oxidoreductase activity
GO:0043914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity
GO:0043914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)H elemental sulfur oxidoreductase activity
GO:0043914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)H:sulfur oxidoreductase activity
GO:0043914	skos:prefLabel	"NAD(P)H sulfur oxidoreductase (CoA-dependent)"
GO:0043914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(P)H sulfur oxidoreductase (CoA-dependent)"
GO:0043914	skos:altLabel	"coenzyme A-dependent NADPH sulfur oxidoreductase"
GO:0043914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-dependent NAD(P)H sulfur oxidoreductase activity
GO:0043914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSR
GO:0043914	skos:altLabel	"S(0) reductase"
GO:0043914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)H sulphur oxidoreductase activity
GO:0043914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH:sulfur oxidoreductase activity
REACT:R-XTR-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Xenopus tropicalis)
REACT:R-MMU-2424480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
RHEA:54653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peregrinol diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O
REACT:R-CFA-5676607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF,sAPRIL binds TACI,BCMA (Canis familiaris)
REACT:R-DME-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
RHEA:57101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-1-thio-D-xylulose 5-phosphate
REACT:R-SPO-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Schizosaccharomyces pombe)
REACT:R-HSA-177926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of PAG by SHP2 (Homo sapiens)
REACT:R-HSA-9006870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT phosphorylation (Homo sapiens)
REACT:R-MMU-5218832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds PAK2 (Mus musculus)
REACT:R-SSC-201443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II receptor phosphorylates type I receptor (Sus scrofa)
REACT:R-MMU-1234167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of HIF:CBP:p300 complex at promoters (Mus musculus)
REACT:R-XTR-2426471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Xenopus tropicalis)
RHEA:23097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)
RHEA:38932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine
RHEA:59283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine <=> D-asparagine
REACT:R-SCE-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Saccharomyces cerevisiae)
REACT:R-BTA-70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine => urocanate + NH4+ (Bos taurus)
REACT:R-HSA-9672163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers (Homo sapiens)
RHEA:70411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetyl-CoA + H2O = 4-hydroxyphenylacetate + CoA + H(+)
REACT:R-SSC-6782820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates SUDS3 (Sus scrofa)
REACT:R-XTR-2201341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TRAM (TICAM2) (Xenopus tropicalis)
GO:0030560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA pseudouridylation guide activity
REACT:R-RNO-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Rattus norvegicus)
REACT:R-SSC-202307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Change of PKC theta conformation (Sus scrofa)
RHEA:42750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(967) in 16S rRNA + S-adenosyl-L-methionine
REACT:R-DRE-416358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) inhibits PI3K alpha (Danio rerio)
GO:0033876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity
GO:0033876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bile acid:PAPS:sulfotransferase activity
GO:0033876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate sulfotransferase activity
GO:0033876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BAST
GO:0033876	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity
GO:0008830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity
GO:0008830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity
GO:0008830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDP-4-ketorhamnose 3,5-epimerase activity
GO:0008830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GO:0008830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphospho-4-ketorhamnose 3,5-epimerase activity
GO:0008830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDP-4-keto-L-rhamnose-3,5-epimerase activity
GO:0102130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA methyltransferase activity
REACT:R-SSC-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Sus scrofa)
RHEA:27472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiose <=> acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine
RHEA:30118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + H2O <=> decanoate + H(+) + holo-[ACP]
REACT:R-DRE-879222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP:NLRP1 binds ATP (Danio rerio)
RHEA:59614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + L-ornithine => beta-alanyl-L-ornithine + H2O
REACT:R-MMU-264689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Mus musculus)
REACT:R-PFA-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Plasmodium falciparum)
RHEA:47112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + glycine = glycochenodeoxycholate + H2O
RHEA:31828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-gamma-cadinene + diphosphate
RHEA:14082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + indole
REACT:R-GGA-8874082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates PTK2 (Gallus gallus)
REACT:R-HSA-9685531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS virus buds into ERGIC lumen (Homo sapiens)
RHEA:33879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-scyllo-inosamine + NADP(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH
REACT:R-CFA-421007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of Ca impermeable AMPA receptors (Canis familiaris)
RHEA:28977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-asparagine(out) => H(+)(out) + L-asparagine(in)
REACT:R-CFA-5686475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Canis familiaris)
RHEA:62902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose
GO:0052618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-0:L-glutamate ligase activity
REACT:R-HSA-1912415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 gene transcription (Homo sapiens)
REACT:R-CFA-352107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Canis familiaris)
RHEA:44640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
REACT:R-SSC-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Sus scrofa)
REACT:R-MMU-9750942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP14 deubiquitinates NLRC5 (Mus musculus)
REACT:R-HSA-1912367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA (Homo sapiens)
GO:0061663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0061663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 ligase activity
REACT:R-BTA-5690856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)
REACT:R-BTA-9027321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)
RHEA:38243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + eicosan-1-ol = 1-O-eicosanyl (9Z)-octadecenoate + CoA
REACT:R-SSC-9708466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y486 BACH1 translocates from the nucleoplasm to the cytosol (Sus scrofa)
RHEA:67514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine
RHEA:19524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + phosphate <=> acetyl phosphate + CoA
REACT:R-RNO-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Rattus norvegicus)
RHEA:20212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + xylitol <=> ADP + H(+) + xylitol 5-phosphate
REACT:R-DDI-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Dictyostelium discoideum)
REACT:R-SSC-9756183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Sus scrofa)
RHEA:39955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)
REACT:R-SSC-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Sus scrofa)
RHEA:60074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2
REACT:R-HSA-5607753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD9 oligomerizes (Homo sapiens)
REACT:R-DRE-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)
RHEA:30709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + L-alanine => putrescine + pyruvate
RHEA:29528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:28434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] = ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]
REACT:R-PFA-5618105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Plasmodium falciparum)
RHEA:62361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-N(5)-peroxide + uracil => (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)
RHEA:49914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + O-propanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-propanoyl-(R)-carnitine(in)
GO:0032442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylcoumaran benzylic ether reductase activity
GO:0032442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCBER activity
REACT:R-HSA-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)
RHEA:66879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) <=> a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH
REACT:R-CEL-5138459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A:FZD4 is endocytosed (Caenorhabditis elegans)
RHEA:51103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:1990446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U1 snRNP binding
REACT:R-HSA-5250875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botF:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
REACT:R-CFA-9706350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates CBL (Canis familiaris)
RHEA:40364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)
REACT:R-HSA-216072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Homo sapiens)
RHEA:62770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2
REACT:R-SSC-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Sus scrofa)
REACT:R-DRE-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Danio rerio)
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin protein ligase activity involved in ERAD pathway
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin protein ligase activity involved in ER-associated degradation pathway
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	E3 involved in endoplasmic reticulum-associated degradation
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin protein ligase activity
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ER-associated E3 ligase
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein ubiquitination activity
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin ligase activity involved in ER-associated degradation pathway
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	APC-Cdc20 complex activity
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	APC-fizzy related complex activity
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ubiquitin protein ligase activity involved in chloroplast disassembly
GO:0061630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin ligase activity
RHEA:64111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
RHEA:45946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA
REACT:R-RNO-9718394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide antagonists (Rattus norvegicus)
RHEA:71639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K(+)(in) + Na(+)(in) = K(+)(out) + Na(+)(out)
REACT:R-DME-211193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization  of DFF40 (Drosophila melanogaster)
REACT:R-SSC-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Sus scrofa)
REACT:R-CFA-1253343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds ERBB4s80 (Canis familiaris)
REACT:R-DDI-9026405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Dictyostelium discoideum)
REACT:R-BTA-8865637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFSD2A transports LPC from extracellular region to plasma membrane (Bos taurus)
REACT:R-XTR-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)
REACT:R-DRE-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Danio rerio)
REACT:R-SPO-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Schizosaccharomyces pombe)
REACT:R-DME-390846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2D3,4 bind to DA (Drosophila melanogaster)
REACT:R-CEL-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Caenorhabditis elegans)
REACT:R-HSA-5340214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB binds O2 (Homo sapiens)
REACT:R-DRE-9610750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Danio rerio)
REACT:R-SSC-174456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments of the C-strand (Sus scrofa)
RHEA:36409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H2O + L-threonylcarbamoyladenylate => ATP + hydrogencarbonate + L-threonine
RHEA:54587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in 18S rRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine
REACT:R-GGA-1112602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Gallus gallus)
REACT:R-HSA-391211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trace amine-associated receptors can bind trace amines (Homo sapiens)
REACT:R-HSA-6784735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR bind to Clathrin (Homo sapiens)
REACT:R-CFA-6786789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer binds FLT3 (Canis familiaris)
RHEA:71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate(in) => (5Z,8Z,11Z,14Z)-eicosatetraenoate(out)
RHEA:14299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O
REACT:R-HSA-5632958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMS2 variants-defective DNA mismatch repair (Homo sapiens)
REACT:R-XTR-8849102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRMS phosphorylates PTK6 (Xenopus tropicalis)
REACT:R-MMU-156808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Mus musculus)
REACT:R-HSA-5694436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 and MIA3 dissociate from procollagen VII vesicle (Homo sapiens)
REACT:R-SSC-5669097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA trimer binds TNFRSF1A,1B,14 (Sus scrofa)
GO:0015383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate:bicarbonate antiporter activity
GO:0015383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphate:bicarbonate antiporter activity
REACT:R-BTA-9661625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FVIII is secreted (Bos taurus)
REACT:R-RNO-199050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Rattus norvegicus)
REACT:R-MMU-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Mus musculus)
REACT:R-MMU-9717206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Mus musculus)
REACT:R-DME-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Drosophila melanogaster)
RHEA:33654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + ATP + CoA <=> (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
RHEA:55802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
EC:1.10.98.-	skos:prefLabel	"With other, known, acceptors"
EC:1.10.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
REACT:R-SSC-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Sus scrofa)
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	death receptor ligand
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TNFR1 binding
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NGFR binding
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	death receptor binding
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	death receptor-associated factor activity
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	death receptor interacting protein activity
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	APO binding
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DR binding
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FAS binding
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	KILLER binding
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	death receptor adaptor protein activity
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TRAIL binding
GO:0005123	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	EDAR binding
RHEA:10155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + NH4(+) <=> ADP + carbamoyl phosphate + H(+) + H2O
RHEA:55089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eburicol + S-adenosyl-L-methionine => (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine
RHEA:68250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine(out) + Na(+)(out) => L-tyrosine(in) + Na(+)(in)
RHEA:13775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:40846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + FADH2
REACT:R-DDI-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Dictyostelium discoideum)
RHEA:17835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxyanthranilate + S-adenosyl-L-methionine
RHEA:30086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Cu(+) + 4 H(+) + O2 <=> 4 Cu(2+) + 2 H2O
REACT:R-PFA-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Plasmodium falciparum)
RHEA:39796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxycholesterol(in) + ATP + H2O => 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate
REACT:R-GGA-421179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate (Gallus gallus)
REACT:R-SSC-5682992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A,B bind H4K20Me2 (Sus scrofa)
REACT:R-CEL-4551721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VHL with SUMO1 (Caenorhabditis elegans)
REACT:R-HSA-8944232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XII (Homo sapiens)
REACT:R-CFA-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Canis familiaris)
RHEA:44248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-BTA-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Bos taurus)
REACT:R-DDI-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Dictyostelium discoideum)
REACT:R-BTA-927813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)
REACT:R-DME-3781024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Drosophila melanogaster)
REACT:R-MMU-6811411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the Golgi (Mus musculus)
GO:0008784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine racemase activity
GO:0008784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine racemase activity
REACT:R-DME-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Drosophila melanogaster)
REACT:R-MMU-1299297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of THIK (Mus musculus)
RHEA:50661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O
RHEA:26284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-5A + H2O <=> acetaldehyde + Co-precorrin-5B + H(+)
GO:0001850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C3a binding
REACT:R-HSA-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Homo sapiens)
REACT:R-HSA-9664933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)
RHEA:43551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
REACT:R-BTA-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Bos taurus)
REACT:R-RNO-2046298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to a branch of keratan (Rattus norvegicus)
RHEA:19784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3,5-diiodo-L-tyrosine <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate
REACT:R-SSC-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Sus scrofa)
RHEA:51406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-arginine + O2
RHEA:31705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol => 2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-9013111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GAPs stimulate RHOC GTPase activity (Canis familiaris)
REACT:R-BTA-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Bos taurus)
REACT:R-HSA-9694581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTC synthesizes SARS-CoV-2 plus strand genomic RNA (Homo sapiens)
REACT:R-SSC-9677579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Sus scrofa)
RHEA:11765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylguanidine => methylamine + urea
RHEA:38038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate <=> (4Z)-2-oxohept-4-enedioate
REACT:R-GGA-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)
REACT:R-BTA-75872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Bos taurus)
RHEA:54151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene <=> 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O
RHEA:44803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-6 + CO2 + diphosphate
REACT:R-DME-5625738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Drosophila melanogaster)
REACT:R-SSC-1475422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPS is phosphorylated by cGMP-dependant protein kinase II (Sus scrofa)
REACT:R-HSA-9617833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 (Homo sapiens)
RHEA:47047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnitine + acetyl-CoA <=> acetoacetate + N,N,N-trimethylglycyl-CoA
RHEA:54419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-campestan-3-one + NADP(+) <=> campest-4-en-3-one + H(+) + NADPH
REACT:R-DDI-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Dictyostelium discoideum)
REACT:R-HSA-9632412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 is recruited to methylated ESR1 (Homo sapiens)
REACT:R-CEL-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Caenorhabditis elegans)
REACT:R-DRE-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Danio rerio)
RHEA:30139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate
RHEA:55523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + 3 isopentenyl diphosphate <=> 3 diphosphate + nerylneryl diphosphate
REACT:R-DME-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Drosophila melanogaster)
RHEA:28863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + lactose(in) = H(+)(in) + lactose(out)
REACT:R-SSC-210300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and TREM2 (Sus scrofa)
REACT:R-DME-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Drosophila melanogaster)
RHEA:21269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-canadine + 2 NADP(+) => berberine + H(+) + 2 NADPH
REACT:R-RNO-159836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)
REACT:R-MMU-9705738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Mus musculus)
RHEA:53518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol
RHEA:65140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + protoaustinoid A = A + berkeleyone A + H2O
RHEA:35106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fusidate(in) <=> fusidate(out)
RHEA:52425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP
REACT:R-BTA-74742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 (Bos taurus)
RHEA:22090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + guanosine 3'-diphosphate 5'-triphosphate => ATP + GTP
REACT:R-DDI-877281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 binds p-STAT1 dimer (Dictyostelium discoideum)
REACT:R-BTA-2213244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides (Bos taurus)
REACT:R-SSC-5669023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TWEAK binds FN14 (Sus scrofa)
REACT:R-SSC-9793679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates RIPK1 at K627 (Sus scrofa)
GO:0004775	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinyl coenzyme A synthetase
GO:0004775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity
GO:0004775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate thiokinase activity
GO:0004775	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinic thiokinase
GO:0004775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA synthetase (ADP-forming) activity
GO:0004775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate-CoA ligase (ADP-forming) activity
GO:0004775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA synthetase activity
REACT:R-MMU-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Mus musculus)
RHEA:31966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-1022133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Sus scrofa)
REACT:R-MMU-2471842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XXV ectomain shedding (Mus musculus)
REACT:R-DME-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Drosophila melanogaster)
GO:0030772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan 2-methyltransferase activity
GO:0030772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan 2-C-methyltransferase activity
GO:0030772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine:tryptophan 2-methyltransferase activity
GO:0030772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity
RHEA:63360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2
RHEA:63360	skos:altLabel	"thiazoline oxidase"
RHEA:63360	skos:prefLabel	"oxazoline dehydrogenase"
RHEA:63360	skos:altLabel	"azoline oxidase"
RHEA:63360	skos:altLabel	"cyanobactin oxidase"
RHEA:63360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxazoline dehydrogenase"
REACT:R-GGA-429415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to integrin alphaIIb beta3 (Gallus gallus)
RHEA:38428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate
RHEA:40711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate
RHEA:23894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitroacrylate + H(+) + NADPH => 3-nitropropanoate + NADP(+)
REACT:R-SCE-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Saccharomyces cerevisiae)
RHEA:52373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-DME-141351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAOX:FAD oxidises NASPN to SPM (Drosophila melanogaster)
REACT:R-DRE-8986258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2:ROBO1 binds CXCR4 (Danio rerio)
REACT:R-XTR-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
REACT:R-SSC-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
RHEA:59792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + yersinopine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate
REACT:R-SSC-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Sus scrofa)
RHEA:15354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin + L-ascorbate => all-trans-antheraxanthin + H2O + L-dehydroascorbate
RHEA:66139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + tyramine <=> CoA + H(+) + N-acetyltyramine
REACT:R-MMU-163733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of FAS monomer gene by ChREBP:MLX (Mus musculus)
REACT:R-RNO-418172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB2 (Rattus norvegicus)
GO:0050336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioethanolamine S-acetyltransferase activity
GO:0050336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thioltransacetylase B activity
GO:0050336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:thioethanolamine S-acetyltransferase activity
GO:0050336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity
GO:0050336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thioethanolamine acetyltransferase activity
REACT:R-SSC-9618021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXG1 binds FOXO:SMAD complexes (Sus scrofa)
RHEA:60475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
REACT:R-RNO-2022860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Rattus norvegicus)
REACT:R-HSA-983427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of peptide bound class I MHC on cell surface (Homo sapiens)
REACT:R-XTR-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Xenopus tropicalis)
REACT:R-CFA-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Canis familiaris)
REACT:R-SPO-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Schizosaccharomyces pombe)
RHEA:38134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol <=> 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-DME-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)
REACT:R-MMU-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Mus musculus)
RHEA:33591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinganine
RHEA:53202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:50411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(2-aminophenyl)decane-1,3-dione <=> 2-heptyl-4(1H)-quinolone + H2O
RHEA:14974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate => D-aspartate
RHEA:49679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)
REACT:R-RNO-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Rattus norvegicus)
REACT:R-DRE-445699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Danio rerio)
REACT:R-CEL-2730872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Calcineurin (Caenorhabditis elegans)
RHEA:51602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:60155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-L-glutamyl-[protein] + H2O <=> L-glutamate + L-glutamyl-[protein]
GO:0030899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent ATPase activity
REACT:R-SSC-1168644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Sus scrofa)
GO:0017099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Homo sapiens)
GO:0017099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-long-chain-acyl-CoA dehydrogenase activity
GO:0017099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very long-chain-acyl-CoA dehydrogenase activity
RHEA:42434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetate => 3-hydroxy-cis,cis-muconate
RHEA:48201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA => reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA
REACT:R-SPO-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Schizosaccharomyces pombe)
REACT:R-DME-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Drosophila melanogaster)
RHEA:65459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-1-ol + acetyl-CoA <=> 2-methylbutyl acetate + CoA
RHEA:16427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + 2 H(+) + NADH => formaldehyde + H2O + NAD(+)
RHEA:16431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
RHEA:65808	skos:prefLabel	"decanoyl-[acyl-carrier protein] acetylenase"
RHEA:65808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:65808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"decanoyl-[acyl-carrier protein] acetylenase"
RHEA:67655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dADP + H2O <=> 2'-deoxyadenosine + diphosphate
RHEA:40645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-MMU-1250383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Mus musculus)
REACT:R-RNO-5683405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP5C dephosphorylates TP53BP1 (Rattus norvegicus)
RHEA:50098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate
REACT:R-XTR-9617370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-antagonists bind ADRA1A,B,D (Xenopus tropicalis)
RHEA:53182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose => D-erythrose
REACT:R-DME-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)
RHEA:54778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine
REACT:R-XTR-8848338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes TAG (Xenopus tropicalis)
RHEA:46796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:58375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-oct-2-en-1-ol + NADP(+) <=> (2E)-octenal + H(+) + NADPH
REACT:R-BTA-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)
RHEA:57881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP
REACT:R-MMU-6784423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Mus musculus)
REACT:R-SPO-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Schizosaccharomyces pombe)
REACT:R-HSA-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Homo sapiens)
GO:1990814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA reannealing activity
GO:1990814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA/DNA annealing activity
REACT:R-GGA-3928640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs phosphorylate MLC (Gallus gallus)
REACT:R-SSC-9708557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 binds BACH1:MAFK (Sus scrofa)
REACT:R-DRE-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)
REACT:R-RNO-8855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR binds DAB1 (Rattus norvegicus)
RHEA:41522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase] => menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-PFA-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Plasmodium falciparum)
RHEA:36469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-alanine => H2O + L-alanylglycine
REACT:R-HSA-6804468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO2 (Homo sapiens)
GO:0030742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent protein binding
RHEA:64289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] => cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-1236943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigen peptide onto MHC class I molecule (Mus musculus)
REACT:R-DRE-6811472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IER3 recruits MAPKs to PP2A-B56-beta,gamma (Danio rerio)
REACT:R-DME-2730840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Drosophila melanogaster)
RHEA:33770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-hydroxy-fatty acyl-CoA <=> a (2E)-enoyl-CoA + H2O
RHEA:13253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)
REACT:R-SCE-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-SSC-391372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRH1,2 (Sus scrofa)
RHEA:12255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-D-glucosyl)-trans-coniferol + H2O <=> (E)-coniferol + D-glucose
GO:0004747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribokinase activity
GO:0004747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribokinase activity
GO:0004747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-ribose 5-phosphotransferase activity
GO:0004747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribokinase activity
GO:0004747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribokinase (phosphorylating)
REACT:R-HSA-9036949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 binds GRB2:SOS1 through SHC1 (Homo sapiens)
RHEA:27425	skos:prefLabel	"beta-farnesene synthase"
RHEA:27425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate
RHEA:27425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-farnesene synthase"
RHEA:27425	skos:altLabel	"farnesene synthase"
RHEA:27425	skos:altLabel	"TPS10"
GO:0048495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Roundabout binding
GO:0048495	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Roundabout receptor binding
RHEA:20779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose <=> myo-inositol + stachyose
REACT:R-DME-8938231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds CREBBP (Drosophila melanogaster)
REACT:R-BTA-5138432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 is phosphorylated by PKC (Bos taurus)
REACT:R-XTR-5625848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Xenopus tropicalis)
GO:0034957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitrophenol nitroreductase activity
REACT:R-DME-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)
RHEA:29520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)
RHEA:17073	skos:prefLabel	"cortisol O-acetyltransferase"
RHEA:17073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cortisol O-acetyltransferase"
RHEA:17073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + cortisol = CoA + cortisol 21-acetate
REACT:R-SSC-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Sus scrofa)
RHEA:46565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + apo-[ACP] => acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)
REACT:R-RNO-5244692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)
EC:3.2.1.157	skos:prefLabel	"iota-carrageenase"
EC:3.2.1.157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"iota-carrageenase"
REACT:R-MMU-193070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPREG to DHA (Mus musculus)
REACT:R-BTA-1299338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRESK (Bos taurus)
RHEA:57794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-6-nitrocatechol + NAD(+) + nitrite => 3,4-dinitrotoluene + NADH + O2
REACT:R-CEL-75879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Caenorhabditis elegans)
RHEA:64238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrochrysone carboxylate + H(+) + holo-[ACP] => atrochrysone carboxyl-[ACP] + H2O
REACT:R-CEL-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Caenorhabditis elegans)
REACT:R-MMU-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Mus musculus)
REACT:R-BTA-187020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of pro-beta-NGF is processed to mature beta-NGF (Bos taurus)
REACT:R-XTR-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Xenopus tropicalis)
REACT:R-RNO-983703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-SYK phosphorylates BLNK (SLP65) (Rattus norvegicus)
REACT:R-RNO-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Rattus norvegicus)
REACT:R-GGA-265936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RPA2 by CDC2 kinase (Gallus gallus)
REACT:R-XTR-2730856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Xenopus tropicalis)
REACT:R-HSA-375135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Basigin binds Matrix metalloproteinase-1 (Homo sapiens)
REACT:R-HSA-164423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PhosphoChREBP (Thr 666)  is exported to cytosol (Homo sapiens)
REACT:R-HSA-2976742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 coactivator complex binds FCER2 promoter (Homo sapiens)
RHEA:71381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in) => D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out)
GO:0043183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Flt-1 binding
GO:0043183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF receptor 1 binding
GO:0043183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vascular endothelial growth factor receptor 1 binding
GO:0043183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR 1 binding
RHEA:42475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzo-p-dioxin + NADH + O2 <=> 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)
RHEA:10766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2
RHEA:18460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)
RHEA:50004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tetracycline = 11a-hydroxytetracycline + H2O + NADP(+)
RHEA:50004	skos:prefLabel	"tetracycline 11a-monooxygenase"
RHEA:50004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetracycline 11a-monooxygenase"
RHEA:41082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SCE-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Saccharomyces cerevisiae)
REACT:R-SSC-158300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Sus scrofa)
REACT:R-CEL-450463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Caenorhabditis elegans)
REACT:R-MMU-110232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by MBD4 glycosylase (Mus musculus)
RHEA:65848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-Delta(1)-steroid + H2O = a steroid 1,3-dione + AH2
REACT:R-CEL-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Caenorhabditis elegans)
GO:1990738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine 5'-phosphatase activity
REACT:R-GGA-193679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-secretase cleaves the p75NTR extracellular domain (Gallus gallus)
REACT:R-MMU-140872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)
RHEA:16934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate + H2O => 2-oxobutanoate + NH4(+)
REACT:R-DME-5635855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Drosophila melanogaster)
RHEA:29721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(I)alamin(out) => cob(I)alamin(in)
REACT:R-SSC-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Sus scrofa)
RHEA:67221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH
REACT:R-RNO-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Rattus norvegicus)
GO:0030248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellulose binding
REACT:R-GGA-983696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Immunoglobulin of the BCR binds antigen (Gallus gallus)
REACT:R-HSA-5621002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB1 activates HOXB2 expression (Homo sapiens)
REACT:R-DRE-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Danio rerio)
REACT:R-PFA-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Plasmodium falciparum)
REACT:R-DDI-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Dictyostelium discoideum)
REACT:R-DDI-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Dictyostelium discoideum)
RHEA:51152	skos:prefLabel	"formylglycine-generating enzyme"
RHEA:51152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a thiol + L-cysteinyl-[sulfatase] + O2 = 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide
RHEA:51152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formylglycine-generating enzyme"
RHEA:51152	skos:altLabel	"sulfatase-modifying factor 1"
RHEA:51152	skos:altLabel	"Calpha-formylglycine-generating enzyme 1"
RHEA:39826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Homo sapiens)
RHEA:71827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate(in) + H(+)(in) = arsenate(out) + H(+)(out)
RHEA:23065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkanesulfonate + FMNH2 + O2 => an aldehyde + FMN + 2 H(+) + H2O + sulfite
RHEA:12890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonate + NAD(+) => 3-dehydro-L-gulonate + H(+) + NADH
RHEA:28898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine(in) + L-lysine(out) <=> cadaverine(out) + L-lysine(in)
REACT:R-SSC-8852200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of LCK by PTPN22 (Sus scrofa)
GO:0015567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkane transmembrane transporter activity
REACT:R-HSA-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
GO:0062059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FACT complex binding
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-uridine diphospho-N-acetylglucosamine transferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoylpyruvate transferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-UDP-acetylglucosamine transferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MurA transferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine enoylpyruvyltransferase activity
GO:0008760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity
REACT:R-DRE-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Danio rerio)
REACT:R-XTR-9749505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC14 binds IKBKB and CHUK (Xenopus tropicalis)
REACT:R-CFA-8862700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMKLR1 binds Resolvin E1 (Canis familiaris)
GO:0047596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-MSA decarboxylase activity
GO:0047596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity
GO:0047596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-methylsalicylate carboxy-lyase (3-cresol-forming)
GO:0047596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylsalicylate decarboxylase activity
GO:0047596	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-methylsalicylate carboxy-lyase activity
RHEA:48173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 + H2O => N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate
RHEA:17922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NAD(+) => D-xylulose + H(+) + NADH
REACT:R-MMU-6807106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN undergoes monoubiquitination (Mus musculus)
REACT:R-DDI-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)
GO:0017067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine-ester sulfotransferase activity
GO:0017067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine methyl ester sulfotransferase activity
GO:0017067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl sulfotransferase IV
GO:0017067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine-ester sulphotransferase activity
GO:0017067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity
REACT:R-HSA-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Homo sapiens)
REACT:R-DME-390329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of AKT by PP2A (Drosophila melanogaster)
REACT:R-RNO-5682794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM22 and ADAM23 (Rattus norvegicus)
REACT:R-XTR-193054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cholesterol to 22beta-hydroxycholesterol (Xenopus tropicalis)
GO:0050356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tropine:NADP+ 3alpha-oxidoreductase activity
GO:0050356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tropine dehydrogenase activity
RHEA:25351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-cysteinyl-tRNA(Pro)"
RHEA:25351	skos:altLabel	"Cys-tRNA(Pro) deacylase"
RHEA:25351	skos:prefLabel	"L-cysteinyl-tRNA(Pro)"
RHEA:25351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinyl-tRNA(Pro) = H(+) + L-cysteine + tRNA(Pro)
RHEA:50361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile + O2 => benzoyl cyanide + H2O2
REACT:R-CFA-139895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAK protein (Canis familiaris)
REACT:R-SSC-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)
RHEA:71240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH => 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)
REACT:R-HSA-8877902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated AR binds RUNX2 (Homo sapiens)
REACT:R-DRE-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
RHEA:26238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeraniol + diphosphate
RHEA:18688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + pentachlorophenol <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)
RHEA:68056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)
RHEA:30706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + salicylate <=> CO2 + phenol
REACT:R-CFA-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Canis familiaris)
RHEA:35422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP
REACT:R-RNO-8952716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 binds Ragulator:Rag dimers (Rattus norvegicus)
REACT:R-CFA-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Canis familiaris)
REACT:R-RNO-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Rattus norvegicus)
REACT:R-HSA-373073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)
RHEA:16565	skos:prefLabel	"histidine transaminase"
RHEA:16565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histidine transaminase"
RHEA:16565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate
RHEA:16565	skos:altLabel	"histidine aminotransferase"
REACT:R-CFA-6799097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates ZNF420 (Canis familiaris)
REACT:R-RNO-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Rattus norvegicus)
GO:0102507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity
REACT:R-DRE-909729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JAK kinases (Danio rerio)
REACT:R-MMU-2465934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL translocates from Muller cells to cone photoreceptor cells (Mus musculus)
RHEA:43134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine
RHEA:30654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + O2 + urate <=> allantoin + CO2 + H2O2
GO:0035402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-T11 kinase activity
GO:0035402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone threonine kinase activity (H3-T11 specific)
GO:0035402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H3-T11 specific)
GO:0035402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-threonine kinase activity (H3-T11 specific)
GO:0035402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3T11 kinase activity
RHEA:47670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+)
REACT:R-CFA-9018880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Canis familiaris)
RHEA:68252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan(in) + Na(+)(in) = L-tryptophan(out) + Na(+)(out)
RHEA:60000	skos:prefLabel	"(hydroxymethyl)phosphonate dioxygenase"
RHEA:60000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(hydroxymethyl)phosphonate dioxygenase"
RHEA:60000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylphosphonate + O2 = formate + 2 H(+) + phosphate
RHEA:25959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3-dehydroquinate + H(+) + NADH + NH4(+)
REACT:R-BTA-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Bos taurus)
REACT:R-RNO-77331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Rattus norvegicus)
REACT:R-GGA-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)
REACT:R-CEL-8875661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA3 associates with activated MET receptor (Caenorhabditis elegans)
REACT:R-HSA-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Homo sapiens)
REACT:R-BTA-5649664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyG from damaged DNA (Bos taurus)
REACT:R-DDI-9018863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Dictyostelium discoideum)
RHEA:43711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + hexadecanoate <=> diphosphate + hexadecanoyl-AMP
RHEA:16491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + mandelonitrile => (R)-prunasin + H2O
RHEA:58350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2
REACT:R-HSA-429613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-RNO-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Rattus norvegicus)
RHEA:24415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxymethyl)benzenesulfonate + NAD(+) <=> 4-formylbenzenesulfonate + H(+) + NADH
GO:0030550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine receptor inhibitor activity
REACT:R-MMU-4085033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Mus musculus)
RHEA:31541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine => (2S)-naringenin + S-adenosyl-L-methionine
RHEA:51789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-5'-AMP + CoA => 2-hydroxybenzoyl-CoA + AMP + H(+)
RHEA:28064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate
REACT:R-XTR-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)
RHEA:30441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly)
REACT:R-GGA-6807118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates monoubiquitinated PTEN (Gallus gallus)
RHEA:57988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP
REACT:R-CEL-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Caenorhabditis elegans)
RHEA:65406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyl hexanoate + CoA => butan-1-ol + hexanoyl-CoA
REACT:R-BTA-9700121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN,MDK):PTPRZ oligomerizes (Bos taurus)
RHEA:38011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a + H2O = chlorophyllide a + H(+) + phytol
RHEA:12621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate = CO2 + L-alanine
RHEA:12621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate 4-decarboxylase"
RHEA:12621	skos:prefLabel	"aspartate 4-decarboxylase"
RHEA:12621	skos:altLabel	"desulfinase"
RHEA:12621	skos:altLabel	"L-aspartate 4-carboxy-lyase"
RHEA:23586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydrofolate + ADP + H(+) + phosphate => 7,8-dihydropteroate + ATP + L-glutamate
RHEA:70853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in) => H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out)
RHEA:63592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
GO:0010489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity
RHEA:54559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-tRNA(His) + ATP + H(+) <=> a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate
REACT:R-XTR-9014456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOG (Xenopus tropicalis)
REACT:R-BTA-8852351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 promotes translocation of TP53 to the cytosol (Bos taurus)
RHEA:64058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2R)-ephedrine + NAD(+)
REACT:R-HSA-416559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)
EC:2.6.99.-	skos:prefLabel	"Transferring other nitrogenous groups"
EC:2.6.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring other nitrogenous groups"
REACT:R-HSA-9610408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17 (Homo sapiens)
REACT:R-HSA-5684261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K8 is phosphorylated (Homo sapiens)
REACT:R-DRE-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Danio rerio)
REACT:R-HSA-913360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)
REACT:R-DME-8875071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSS3 ligates CoA to CH3COO- (Drosophila melanogaster)
RHEA:57302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O
GO:0102467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scutellarein 7-O-glucuronosyltransferase activity
REACT:R-HSA-8848939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds KHDRBS1 (Homo sapiens)
RHEA:65181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + protoaustinoid B => A + H2O + preaustinoid A
RHEA:32686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethylfurfural + 2 H2O + 3 O2 <=> 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2
REACT:R-XTR-198266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)
REACT:R-BTA-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Bos taurus)
GO:0047454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phaseollidin-hydrate hydro-lyase (phaseollidin-forming)
GO:0047454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phaseollidin hydratase activity
GO:0047454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phaseollidin-hydrate hydro-lyase activity
REACT:R-CFA-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Canis familiaris)
REACT:R-DME-9021170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen stimulates dimerization of plasma membrane estrogen receptors (Drosophila melanogaster)
GO:1905108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine binding
REACT:R-BTA-204779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang1 (Bos taurus)
RHEA:43765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + chenodeoxycholate + CoA => AMP + chenodeoxycholoyl-CoA + diphosphate
GO:0050249	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	luciferin sulfokinase activity
GO:0050249	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)
GO:0050249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renilla-luciferin sulphotransferase activity
GO:0050249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renilla-luciferin sulfotransferase activity
GO:0050249	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	luciferin sulfotransferase activity
GO:0050249	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity
REACT:R-HSA-1604731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP3 (Homo sapiens)
RHEA:44768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) = 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2
RHEA:70943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(in) = L-isoleucine(out)
REACT:R-HSA-4224014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by ADAM10, ADAM15 (Homo sapiens)
REACT:R-HSA-429730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Homo sapiens)
REACT:R-RNO-1604741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP14 (MT1-MMP) (Rattus norvegicus)
REACT:R-RNO-8981657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds PTPRZ1 (Rattus norvegicus)
REACT:R-BTA-183130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Bos taurus)
REACT:R-HSA-5627737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3 does not exchange Cl- for HCO3- (Homo sapiens)
REACT:R-GGA-422021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Gallus gallus)
EC:2.4.99.2	skos:prefLabel	"beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase"
EC:2.4.99.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase"
EC:2.4.99.2	skos:altLabel	"monosialoganglioside sialyltransferase"
REACT:R-GGA-429955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR4-NOT complex deadenylates mRNA (Gallus gallus)
RHEA:19136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3,3',5-triiodo-L-thyronine <=> 3,5,3'-triiodothyropyruvate + L-glutamate
REACT:R-CFA-8985594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYO9B inactivates RHOA (Canis familiaris)
REACT:R-BTA-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Bos taurus)
RHEA:64987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-9750942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
REACT:R-CFA-5607753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD9 oligomerizes (Canis familiaris)
RHEA:40020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate + H2O => (-)-ent-copalol + diphosphate
RHEA:29431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + phosphate = ADP + diphosphate
RHEA:22157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H2O => GMP + H(+) + phosphate
REACT:R-MMU-8964614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Mus musculus)
RHEA:29764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate
GO:0043791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity
GO:0043791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[dimethylamine--corrinoid protein] Co-methyltransferase"
GO:0043791	skos:prefLabel	"[dimethylamine--corrinoid protein] Co-methyltransferase"
GO:0043791	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	MT1
GO:0043791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMA methyltransferase 1
GO:0043791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMAMT 1
GO:0043791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) = methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine
GO:0043791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine methyltransferase activity
GO:0043791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mtbB1
GO:0043791	skos:altLabel	"dimethylamine methyltransferase"
GO:0043791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine:corrinoid methyltransferase activity
RHEA:10909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + glycolithocholate => adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate
RHEA:49933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-octadienoyl-CoA => (2E,5Z)-octadienoyl-CoA
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-2,8-sialyltransferase activity
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GD3 synthase activity
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ganglioside GD3 synthase activity
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SAT-2
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ganglioside GD3 synthetase sialyltransferase activity
GO:0003828	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphoacetylneuraminate-ganglioside GM3
RHEA:28630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + solavetivol <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone
REACT:R-MMU-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Mus musculus)
RHEA:43996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 = a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate
RHEA:42543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(13) in tRNA <=> pseudouridine(13) in tRNA
REACT:R-SCE-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)
REACT:R-RNO-6805103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates TP53 (Rattus norvegicus)
RHEA:26120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-379426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Homo sapiens)
RHEA:19315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate
RHEA:57748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH = C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
REACT:R-HSA-6801766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Homo sapiens)
REACT:R-DRE-5692408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPR2 binds NPPC (Danio rerio)
REACT:R-MMU-193665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYD88 dissociates (Mus musculus)
REACT:R-GGA-9607304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Gallus gallus)
REACT:R-SCE-5694421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6 dephosphorylates SEC24 (Saccharomyces cerevisiae)
GO:0018781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-triazine hydrolase activity
RHEA:31663	skos:altLabel	"UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase"
RHEA:31663	skos:altLabel	"UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase"
RHEA:31663	skos:prefLabel	"UDP-N-acetylbacillosamine transaminase"
RHEA:31663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-N-acetylbacillosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
RHEA:31663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylbacillosamine transaminase"
RHEA:31663	skos:altLabel	"UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase"
REACT:R-RNO-390597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Rattus norvegicus)
RHEA:37697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA
REACT:R-DRE-9617927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO4 binds ATXN3 (Danio rerio)
REACT:R-RNO-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Rattus norvegicus)
GO:0050016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenic acid hydroxylase activity
GO:0050016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine 7,8-hydroxylase activity
GO:0050016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenate 7,8-hydroxylase activity
GO:0050016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenic hydroxylase activity
GO:0050016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
REACT:R-XTR-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Xenopus tropicalis)
RHEA:20026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A3 + UDP-alpha-D-glucose => gibberellin A3 O-beta-D-glucoside + H(+) + UDP
REACT:R-RNO-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Rattus norvegicus)
RHEA:29570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(in) + H(+)(out) <=> 2 chloride(out) + H(+)(in)
GO:1904854	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	20S proteasome binding
GO:1904854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macropain binding
GO:1904854	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	20S core complex binding
GO:1904854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteasome core complex binding
GO:1904854	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PA28gamma-20S proteasome binding
RHEA:52554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-O-phospho-L-erythronate + ADP + H(+) => 3-dehydro-L-erythronate + ATP
REACT:R-BTA-6814670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Bos taurus)
REACT:R-XTR-264615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Xenopus tropicalis)
GO:0103077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-glucoside 7-O-rhamnosyltransferase activity
RHEA:61547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-5654625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds SHC1 (Canis familiaris)
RHEA:59356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lactobiono-1,5-lactone = H(+) + lactobionate
REACT:R-SSC-6789092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide anion from oxygen (Sus scrofa)
REACT:R-CFA-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Canis familiaris)
REACT:R-DRE-372697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binding to p130cas (Danio rerio)
REACT:R-MMU-374681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 and NCAM1 engaged in cis-interaction (Mus musculus)
REACT:R-DRE-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Danio rerio)
RHEA:66903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-tryptophan + malonyl-CoA <=> CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O
REACT:R-BTA-9731924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds EDNs (Bos taurus)
RHEA:14904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> casbene + diphosphate
REACT:R-PFA-548815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Plasmodium falciparum)
REACT:R-XTR-5682598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates HERC2 (Xenopus tropicalis)
REACT:R-DRE-1169192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B dephosphorylates GHR (Danio rerio)
REACT:R-CFA-1295599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 translocates to the plasma membrane (Canis familiaris)
REACT:R-SSC-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Sus scrofa)
RHEA:47083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyestr-4-en-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-estran-3-one + NADP(+)
REACT:R-CEL-8875482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)
RHEA:32885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic aldehyde + H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + NADP(+)
RHEA:41025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA
REACT:R-SPO-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Schizosaccharomyces pombe)
REACT:R-HSA-75096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
REACT:R-SSC-9664855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Sus scrofa)
RHEA:50657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O
GO:1990175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EH domain binding
REACT:R-DDI-375790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Dictyostelium discoideum)
REACT:R-SSC-6804955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDM2 (Sus scrofa)
REACT:R-SSC-210304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with PECAM1 (Sus scrofa)
RHEA:28598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-lysine = acetate + L-lysine
REACT:R-DRE-6788523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to Complex I subunits (Danio rerio)
REACT:R-CFA-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Canis familiaris)
GO:0031928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine transmembrane transporter activity
GO:0031928	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyridoxine transporter activity
RHEA:63469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-octaprenol + ATP => ADP + all-trans-octaprenyl phosphate + H(+)
REACT:R-DME-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Drosophila melanogaster)
REACT:R-GGA-5682629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Gallus gallus)
REACT:R-HSA-8874201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L3 (Homo sapiens)
REACT:R-BTA-166538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The bound receptor dimerizes (Bos taurus)
REACT:R-DME-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Drosophila melanogaster)
RHEA:66593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA => a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)
RHEA:43036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine = 2-aminoprop-2-enoate + H(+) + hydrogen sulfide
REACT:R-DDI-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Dictyostelium discoideum)
REACT:R-BTA-9028730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FRS2 (Bos taurus)
REACT:R-RNO-9014420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the phagocytic vesicle membrane (Rattus norvegicus)
RHEA:15629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steroid 11beta-monooxygenase"
RHEA:15629	skos:altLabel	"steroid 11beta/18-hydroxylase"
RHEA:15629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]
RHEA:15629	skos:altLabel	"cytochrome p450 XIB1"
RHEA:15629	skos:prefLabel	"steroid 11beta-monooxygenase"
RHEA:15629	skos:altLabel	"steroid 11beta-hydroxylase"
REACT:R-CEL-159431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Caenorhabditis elegans)
REACT:R-MMU-434836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk/Lck phosphorylate LAT (Mus musculus)
REACT:R-RNO-5668629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Rattus norvegicus)
RHEA:39044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:58759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)
REACT:R-SPO-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Schizosaccharomyces pombe)
REACT:R-DRE-6786034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Danio rerio)
REACT:R-DRE-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Danio rerio)
RHEA:48742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine
REACT:R-BTA-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Bos taurus)
RHEA:69898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(out) + Na(+)(out) <=> cytidine(in) + Na(+)(in)
RHEA:24487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + sulcatol <=> H(+) + NADH + sulcatone
RHEA:16426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + NAD(+) => formate + 2 H(+) + NADH
REACT:R-RNO-2395302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysino-5-ketonorleucine cross-links (Rattus norvegicus)
REACT:R-RNO-8948228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Rattus norvegicus)
RHEA:35251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate
REACT:R-CEL-751039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (12/13) reassociates with G beta:gamma (Caenorhabditis elegans)
REACT:R-DME-6782628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates STAM2:HGS (Drosophila melanogaster)
REACT:R-BTA-8944230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Bos taurus)
REACT:R-HSA-1168789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHR internalization (Homo sapiens)
RHEA:67174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite => O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-9673284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)
REACT:R-XTR-4719436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO1 (Xenopus tropicalis)
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transfer RNA pseudouridine synthetase activity
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tRNA pseudouridine(65) synthase
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tRNA pseudouridylate synthase I activity
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tRNA pseudouridine(32) synthase
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tRNA pseudouridine(31) synthase
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tRNA pseudouridine(38-40) synthase
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-uridine isomerase activity
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA pseudouridine synthase activity
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Mitochondrial tRNA pseudouridine(27/28) synthase
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tRNA-pseudouridine synthase I activity
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transfer ribonucleate pseudouridine synthetase activity
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tRNA pseudouridine(55) synthase
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-pseudouridine synthase activity
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tRNA pseudouridine(13) synthase
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-uridine uracilmutase activity
GO:0106029	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tRNA pseudouridine(38/39) synthase
REACT:R-BTA-5607058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C:PROCR binds F2R (Bos taurus)
REACT:R-CEL-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Caenorhabditis elegans)
REACT:R-RNO-194311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Rattus norvegicus)
REACT:R-SSC-3000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BORA binds PLK1 and AURKA (Sus scrofa)
REACT:R-SCE-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Saccharomyces cerevisiae)
REACT:R-XTR-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Xenopus tropicalis)
REACT:R-CEL-8874079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated MET (Caenorhabditis elegans)
REACT:R-HSA-83723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Homo sapiens)
REACT:R-GGA-5624131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B binds myristoylated proteins (Gallus gallus)
RHEA:47768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-PFA-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Plasmodium falciparum)
RHEA:38091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocotrienol + S-adenosyl-L-methionine = beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine
GO:0016937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0016937	skos:altLabel	"short-chain acyl CoA dehydrogenase"
GO:0016937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"short-chain acyl-CoA dehydrogenase"
GO:0016937	skos:altLabel	"butyryl dehydrogenase"
GO:0016937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	short-branched-chain-acyl-CoA dehydrogenase activity
GO:0016937	skos:altLabel	"butanoyl-CoA dehydrogenase"
GO:0016937	skos:altLabel	"unsaturated acyl-CoA reductase"
GO:0016937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0016937	skos:prefLabel	"short-chain acyl-CoA dehydrogenase"
REACT:R-SSC-5668718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)
RHEA:28067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) => alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:14482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
GO:0051720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates
REACT:R-HSA-6805650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
RHEA:22231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + presqualene diphosphate <=> diphosphate + NAD(+) + squalene
REACT:R-XTR-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Xenopus tropicalis)
RHEA:69744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-benzylsuccinate + succinyl-CoA => (S)-2-benzylsuccinyl-CoA + succinate
REACT:R-DME-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Drosophila melanogaster)
REACT:R-BTA-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Bos taurus)
REACT:R-XTR-400097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-beta:G-gamma inhibits Adenylate cyclase (Xenopus tropicalis)
REACT:R-XTR-8955289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
RHEA:35999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-MMU-193696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Mus musculus)
REACT:R-RNO-5666160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)
REACT:R-GGA-8871265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD4 (Gallus gallus)
REACT:R-DME-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Drosophila melanogaster)
GO:0016859	skos:prefLabel	"Cis-trans-isomerases"
GO:0016859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-trans isomerase activity
GO:0016859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Cis-trans-isomerases"
REACT:R-BTA-1169394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of IRF3 (Bos taurus)
RHEA:58677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + rifamycin SV => H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide
REACT:R-GGA-2132284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C5b:C6 (Gallus gallus)
REACT:R-XTR-1566962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by elastin-degrading extracellular proteinases (Xenopus tropicalis)
RHEA:10990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 e(-) + 2 H(+) + 2 nitric oxide => H2O + nitrous oxide
REACT:R-CFA-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Canis familiaris)
RHEA:59334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-hydroxytorulene + AH2 => 1'-hydroxy-gamma-carotene + A
RHEA:33827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol = vitamin D2
REACT:R-MMU-982810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation (Mus musculus)
REACT:R-HSA-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Homo sapiens)
REACT:R-DRE-5333671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCAs self cleave (Danio rerio)
REACT:R-DRE-215526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F3 20-hydroxylates LTB4 (Danio rerio)
GO:0047349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:D-ribitol-5-phosphate cytidylyltransferase activity
GO:0047349	skos:prefLabel	"D-ribitol-5-phosphate cytidylyltransferase"
GO:0047349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-ribitol pyrophosphorylase activity
GO:0047349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphate ribitol pyrophosphorylase activity
GO:0047349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoribitol pyrophosphorylase activity
GO:0047349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol-5-phosphate cytidylyltransferase activity
GO:0047349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate
GO:0047349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribitol 5-phosphate cytidylyltransferase activity
GO:0047349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-ribitol diphosphorylase activity
GO:0047349	skos:altLabel	"CDP-ribitol pyrophosphorylase"
GO:0047349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-ribitol-5-phosphate cytidylyltransferase"
GO:0047349	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP ribitol pyrophosphorylase activity
GO:0047349	skos:altLabel	"CDP-ribitol diphosphorylase"
REACT:R-CEL-451283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kainate receptor binds glutamate (Caenorhabditis elegans)
REACT:R-HSA-2691219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 HD domain mutants bind DLL1 (Homo sapiens)
REACT:R-DME-9008258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 binds ESR1:estrogen:TFGA gene (Drosophila melanogaster)
REACT:R-CFA-5694563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD10 hydrolyses MPAG (Canis familiaris)
REACT:R-GGA-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Gallus gallus)
RHEA:28018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin + 3 H2O = 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-RNO-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Rattus norvegicus)
REACT:R-SSC-8854899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Sus scrofa)
REACT:R-XTR-6804383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 methylates TP53 (Xenopus tropicalis)
RHEA:54030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-DME-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)
RHEA:46411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-5654614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
REACT:R-HSA-8878023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)
RHEA:69901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + thymidine(in) => 2 Na(+)(out) + thymidine(out)
REACT:R-SSC-9023884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to TGFA promoter (Sus scrofa)
RHEA:21401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CoA + NADP(+) => CO2 + NADPH + succinyl-CoA
RHEA:46878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate
RHEA:67647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dZDP <=> ADP + dZTP
REACT:R-SSC-193401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
RHEA:24551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-acyl-L-lysine + H2O <=> a carboxylate + L-lysine
RHEA:72903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyrolactone II + dimethylallyl diphosphate = butyrolactone I + diphosphate
RHEA:40034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate + H2O <=> diphosphate + ent-manool
REACT:R-GGA-8874080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates PTK2 (Gallus gallus)
REACT:R-CFA-5689000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Canis familiaris)
REACT:R-HSA-9634445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)
REACT:R-SSC-191636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cx43 by c-src (Sus scrofa)
RHEA:10284	skos:prefLabel	"leucine 2,3-aminomutase"
RHEA:10284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leucine 2,3-aminomutase"
RHEA:10284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine = (3R)-beta-leucine
REACT:R-SCE-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Saccharomyces cerevisiae)
RHEA:64303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropylamine + pyruvate <=> 3-phenylpropanal + L-alanine
RHEA:31527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-hydroxy-L-arginine = (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O
RHEA:33421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA
REACT:R-DME-5099886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binding to FZD promotes PRICKLE1 degradation (Drosophila melanogaster)
GO:1990174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphodiesterase decapping endonuclease activity
GO:1990174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	G(5')pppN pyrophosphatase activity
RHEA:17120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + methylamine <=> ADP + H(+) + N(5)-methyl-L-glutamine + phosphate
REACT:R-HSA-9619125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK phosphorylates CAMK4 (Homo sapiens)
REACT:R-HSA-4551648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO1 (Homo sapiens)
RHEA:59495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + L-tryptophyl-[protein] <=> (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate
RHEA:30689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + pyruvate => (4R)-4-hydroxy-2-oxoglutarate
RHEA:30442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)
REACT:R-RNO-914012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Rattus norvegicus)
GO:0033754	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tryptophan pyrrolase activity
GO:0033754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoleamine 2,3-dioxygenase activity
GO:0033754	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IDO
GO:0033754	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity
RHEA:27733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) <=> beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate
REACT:R-RNO-3965450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits PFN1 (Rattus norvegicus)
RHEA:43989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)
RHEA:59621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(4-aminobutanoyl)-L-lysine => 4-aminobutanoate + L-lysine
REACT:R-DRE-2395257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-hydroxylysino-norleucine cross-links (Danio rerio)
REACT:R-BTA-5625797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Bos taurus)
REACT:R-XTR-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Xenopus tropicalis)
RHEA:16961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
RHEA:16961	skos:prefLabel	"gamma-glutamylamine cyclotransferase"
RHEA:16961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-glutamylamine cyclotransferase"
REACT:R-XTR-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Xenopus tropicalis)
RHEA:32022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> beta-cubebene + diphosphate
RHEA:37954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate
RHEA:14114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O => a 3'-end 2'-deoxyribonucleotide-DNA + phosphate
RHEA:54448	skos:altLabel	"peptidyl-tRNA hydrolase"
RHEA:54448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminoacyl-tRNA hydrolase"
RHEA:54448	skos:prefLabel	"aminoacyl-tRNA hydrolase"
RHEA:54448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)
REACT:R-SSC-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Sus scrofa)
REACT:R-HSA-2186741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)
REACT:R-XTR-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Xenopus tropicalis)
REACT:R-RNO-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Rattus norvegicus)
REACT:R-SSC-2484822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore assembly (Sus scrofa)
REACT:R-RNO-111742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)
RHEA:13572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP
REACT:R-RNO-8936608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)
RHEA:16385	skos:altLabel	"4-hydroxybenzoate 1-monooxygenase"
RHEA:16385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoate 1-hydroxylase"
RHEA:16385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 H(+) + NADPH + O2 = CO2 + H2O + hydroquinone + NADP(+)
RHEA:16385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 H(+) + NADH + O2 = CO2 + H2O + hydroquinone + NAD(+)
RHEA:16385	skos:prefLabel	"4-hydroxybenzoate 1-hydroxylase"
REACT:R-GGA-264871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin B1 (Gallus gallus)
REACT:R-SSC-2870221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-selectin binds E-selectin ligand (Sus scrofa)
REACT:R-XTR-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Xenopus tropicalis)
REACT:R-RNO-8869506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Rattus norvegicus)
REACT:R-RNO-5696997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP24 deubiquitinates DDB2 (Rattus norvegicus)
REACT:R-BTA-4641236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates FZD to potentiate WNT signaling (Bos taurus)
RHEA:30197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9',15-tri-cis-zeta-carotene + plastoquinol-9 => 15,9'-di-cis-phytofluene + plastoquinone-9
REACT:R-DRE-5623519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP and RAB8A bind to the ciliary targeting complex (Danio rerio)
REACT:R-BTA-5685011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR activation at DNA DSBs (Bos taurus)
RHEA:52214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:50595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) <=> 15-oxoprostaglandin F1alpha + H(+) + NADPH
REACT:R-XTR-6809320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Xenopus tropicalis)
RHEA:72314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(in) + taurocholate(out) <=> glutathione(out) + taurocholate(in)
RHEA:63112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ascofuranol = AH2 + ascofuranone
REACT:R-CEL-1889955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT dimers transfer GlcA to tetrasaccharide linker (Caenorhabditis elegans)
REACT:R-DRE-2730876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IKK-beta by TAK1 (Danio rerio)
REACT:R-BTA-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Bos taurus)
REACT:R-CFA-2395768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPL hydrolyses TGs from mature CMs (Canis familiaris)
REACT:R-CEL-8850529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGS proteins bind GNB5 and CCT/TRiC (Caenorhabditis elegans)
REACT:R-RNO-204798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and p85 of PI3K (Rattus norvegicus)
REACT:R-SSC-1855202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Sus scrofa)
GO:0004407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone deacetylase activity
RHEA:63991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-thiocytidine + ATP <=> 2-thiocytidine 5'-phosphate + ADP + H(+)
REACT:R-RNO-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Rattus norvegicus)
RHEA:61137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + quercetin + succinate
RHEA:47592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) = CMP + ganglioside GP1c (d18:1(4E)) + H(+)
RHEA:33645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + AMP + diphosphate => (9Z)-tetradecenoate + ATP + CoA
REACT:R-RNO-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Rattus norvegicus)
REACT:R-XTR-390595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Troponin-C (Xenopus tropicalis)
RHEA:12660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-methylacyl-CoA <=> a (2R)-2-methylacyl-CoA
RHEA:25287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:31627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"10-deoxymethynolide desosaminyltransferase"
RHEA:31627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethynolide + dTDP-alpha-D-desosamine = 10-deoxymethymycin + dTDP + H(+)
RHEA:31627	skos:altLabel	"glycosyltransferase DesVII"
RHEA:31627	skos:prefLabel	"10-deoxymethynolide desosaminyltransferase"
RHEA:27617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate <=> di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate
RHEA:67216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O
REACT:R-CFA-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Canis familiaris)
RHEA:66723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) <=> ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate
REACT:R-BTA-200421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of cytosolic AMPK by phosphorylation (Bos taurus)
REACT:R-DRE-844438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 oligomerizes (Danio rerio)
REACT:R-SCE-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Saccharomyces cerevisiae)
RHEA:43778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine(out) => an N-(acyl)-sphingosylphosphocholine(in)
GO:1903794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol binding
REACT:R-DRE-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Danio rerio)
RHEA:47327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-3-phenylpropanoate + pyruvate <=> 3-oxo-3-phenylpropanoate + L-alanine
REACT:R-HSA-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RHEA:44115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + nonan-1-ol <=> CoA + nonyl hexadecanoate
REACT:R-SSC-749452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gq complex dissociates (Sus scrofa)
RHEA:20674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH
RHEA:72668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + secologanin => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin
RHEA:43083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Canis familiaris)
REACT:R-BTA-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Bos taurus)
REACT:R-RNO-2473151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister centromeres (Rattus norvegicus)
REACT:R-SSC-5683425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53BP1 at DNA DSBs (Sus scrofa)
RHEA:25398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
RHEA:62615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine
RHEA:11944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)
RHEA:45349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine
REACT:R-DME-8931981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ESR1 (Drosophila melanogaster)
RHEA:26346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactonate + NADP(+) => aldehydo-D-galacturonate + H(+) + NADPH
RHEA:52790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg(2+) + pheophytin a => chlorophyll a + 2 H(+)
REACT:R-BTA-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Bos taurus)
REACT:R-DRE-74707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IRS to insulin receptor (Danio rerio)
RHEA:30345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + fumarate => FAD + H(+) + succinate
RHEA:68491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxytetradecanoate + H(+) <=> CO2 + H2O + tridecanal
REACT:R-DRE-1433451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds to p-KIT (Danio rerio)
REACT:R-DME-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Drosophila melanogaster)
REACT:R-SSC-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Sus scrofa)
RHEA:71983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene B
REACT:R-XTR-2168887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Albumin to Hemopexin (Xenopus tropicalis)
RHEA:18209	skos:altLabel	"bornyl pyrophosphate synthase"
RHEA:18209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-bornyl diphosphate synthase"
RHEA:18209	skos:prefLabel	"(+)-bornyl diphosphate synthase"
RHEA:18209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (2S,4R)-bornyl diphosphate
RHEA:18209	skos:altLabel	"geranyl-diphosphate cyclase"
RHEA:18209	skos:altLabel	"bornyl pyrophosphate synthetase"
REACT:R-DRE-6788867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3K phosphorylates ketosamines (Danio rerio)
REACT:R-GGA-5692768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates KALRN (Gallus gallus)
RHEA:60128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate
REACT:R-HSA-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Homo sapiens)
REACT:R-DME-451561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO binds polyubiquitinated IRAK1 (Drosophila melanogaster)
RHEA:24792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate
REACT:R-CFA-9691621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5 binds C5 inhibitors (Canis familiaris)
REACT:R-BTA-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Bos taurus)
REACT:R-CFA-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)
REACT:R-XTR-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Xenopus tropicalis)
REACT:R-HSA-5218952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)
RHEA:38675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-BTA-4641253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 ubiquitinates FZD to promote its downregulation (Bos taurus)
REACT:R-RNO-6809680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTM1 (Rattus norvegicus)
RHEA:42409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate + ATP => (2R)-2,3-bisphosphoglycerate + ADP + H(+)
REACT:R-CFA-209925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIT and MIT combine to form triiodothyronine (Canis familiaris)
RHEA:62399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-pseudoephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
REACT:R-MMU-2247511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2:ligand is endocytosed (Mus musculus)
REACT:R-HSA-3322429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP monoubiquinates TLE (Homo sapiens)
EC:2.4.2.46	skos:prefLabel	"galactan 5-O-arabinofuranosyltransferase"
EC:2.4.2.46	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactan 5-O-arabinofuranosyltransferase"
RHEA:20237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)
REACT:R-MMU-5665727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds CDC42:GTP (Mus musculus)
REACT:R-MMU-71825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Mus musculus)
RHEA:20534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyridoxal 5'-phosphate => phosphate + pyridoxal
REACT:R-HSA-8851352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR8 binds CCL1 (Homo sapiens)
REACT:R-MMU-5676917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Mus musculus)
RHEA:27694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O
REACT:R-HSA-9035950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective B4GALT1 does not transfer Gal to a branch of keratan (Homo sapiens)
REACT:R-MMU-9629149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves thymine glycol from damaged DNA (Mus musculus)
REACT:R-MMU-8951499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides on to class I MHC (Mus musculus)
REACT:R-MMU-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Mus musculus)
GO:0008297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	single-stranded DNA specific exodeoxyribonuclease activity
GO:0008297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ssDNA-specific exodeoxyribonuclease activity
GO:0008297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded DNA exodeoxyribonuclease activity
RHEA:19926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 5-phosphate + NAD(+) => D-ribulose 5-phosphate + H(+) + NADH
REACT:R-BTA-2243931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-lysinonorleucine cross-links (Bos taurus)
REACT:R-DRE-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Danio rerio)
REACT:R-CEL-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Caenorhabditis elegans)
REACT:R-SSC-201457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP2 binds to the receptor complex (Sus scrofa)
RHEA:24216	skos:prefLabel	"farnesal dehydrogenase"
RHEA:24216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"farnesal dehydrogenase"
RHEA:24216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH
REACT:R-MMU-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Mus musculus)
REACT:R-GGA-190385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3b (Gallus gallus)
REACT:R-RNO-2168884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Methemoglobin to Hemopexin (Rattus norvegicus)
REACT:R-SSC-8964274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12) binds BTK (Sus scrofa)
REACT:R-XTR-9026408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Xenopus tropicalis)
GO:0047616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl coenzyme A reductase activity
GO:0047616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA dehydrogenase (NADP+) activity
GO:0047616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:NADP+ 2-oxidoreductase activity
GO:0047616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	crotonyl coenzyme A reductase activity
GO:0047616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-enoyl-CoA reductase activity
GO:0047616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)
REACT:R-GGA-159046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Gallus gallus)
REACT:R-DME-5635865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 dissociates from ub-PTCH1 (Drosophila melanogaster)
REACT:R-SSC-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Sus scrofa)
REACT:R-CFA-8852354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 facilitates proteasome-mediated degradation of TP53 (Canis familiaris)
REACT:R-RNO-3225851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin and activate MAP3K5 (Rattus norvegicus)
REACT:R-CFA-6814165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates CSA to HTAU (Canis familiaris)
RHEA:64733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate
REACT:R-SSC-5610722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI3 (Sus scrofa)
REACT:R-XTR-3323013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)
REACT:R-HSA-5690250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Homo sapiens)
RHEA:31203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA
REACT:R-HSA-9683635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E pentamer is transported to the Golgi (Homo sapiens)
REACT:R-HSA-9694341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike protein gets palmitoylated (Homo sapiens)
REACT:R-DME-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Drosophila melanogaster)
REACT:R-SCE-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Saccharomyces cerevisiae)
REACT:R-HSA-2396594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
REACT:R-RNO-432129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds and phosphorylates LRP8 (Rattus norvegicus)
RHEA:24142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine
RHEA:35892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-HSA-2468287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
REACT:R-XTR-196372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Xenopus tropicalis)
GO:0043773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420-0 gamma-glutamyl ligase activity
GO:0043773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-0 gamma-glutamyl ligase activity
REACT:R-RNO-9038029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxysterol binds ESR1, ESR2 (Rattus norvegicus)
REACT:R-GGA-2132061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor B binds to surface-bound C3b fragment (Gallus gallus)
REACT:R-BTA-195378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of VEGF proteins (Bos taurus)
REACT:R-CFA-5357757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)
REACT:R-HSA-158800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Homo sapiens)
RHEA:28835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + succinate(in) = citrate(in) + succinate(out)
REACT:R-CFA-5205820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)
RHEA:70281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + raffinose => H2O + stachyose
GO:0047920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geissoschizine:NADP+ 4,21-oxidoreductase activity
GO:0047920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geissoschizine dehydrogenase activity
RHEA:50317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl octadecanoate + H2O => ethanol + H(+) + octadecanoate
RHEA:29173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + 2 H(+) + 2 superoxide => a ubiquinol + 2 O2
REACT:R-CEL-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Caenorhabditis elegans)
REACT:R-RNO-5675470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC2/3 (cIAP1/2) is autoubiquitinated (Rattus norvegicus)
RHEA:20878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein] => (R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:50005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tetracycline => 11a-hydroxytetracycline + H2O + NADP(+)
REACT:R-RNO-6804762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 forms homotetramers (Rattus norvegicus)
GO:0008307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of muscle
REACT:R-DDI-9027321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)
REACT:R-SSC-141409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mad1 binds kinetochore (Sus scrofa)
REACT:R-DME-3000137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Drosophila melanogaster)
REACT:R-DRE-8855375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dissociates from CSK (Danio rerio)
RHEA:72905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyrolactone I + diphosphate => butyrolactone II + dimethylallyl diphosphate
REACT:R-SSC-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Sus scrofa)
REACT:R-HSA-170706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of  NEFL by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
RHEA:40737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-glucose + gypenoside LXXV => (20S)-ginsenoside Rb1 + 2 H2O
RHEA:55081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + D-fructose => ADP + H(+) + sucrose
REACT:R-CFA-174446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap from the C-strand (Canis familiaris)
RHEA:34190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate
GO:0031865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostanoid EP2 receptor binding
GO:0031865	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	EP2 subtype prostaglandin E2 receptor ligand
GO:0031865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 subtype prostaglandin E2 receptor binding
REACT:R-SSC-5665727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds CDC42:GTP (Sus scrofa)
REACT:R-BTA-70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Bos taurus)
REACT:R-SSC-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Sus scrofa)
RHEA:12866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methyladenosine + H2O => 1-methyladenine + D-ribose
RHEA:60576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[methyl-Co(III) tetramethylammonium-specific corrinoid protein]:coenzyme M methyltransferase"
RHEA:60576	skos:prefLabel	"[methyl-Co(III) tetramethylammonium-specific corrinoid protein]:coenzyme M methyltransferase"
RHEA:60576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] = Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-BTA-429694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 dissociates from the endoplasmic reticulum (Bos taurus)
REACT:R-HSA-5632393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP63/TP53 bind the DDIT4 gene promoter (Homo sapiens)
EC:2.7.10.2	skos:altLabel	"cytoplasmic protein tyrosine kinase"
EC:2.7.10.2	skos:prefLabel	"non-specific protein-tyrosine kinase"
EC:2.7.10.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"non-specific protein-tyrosine kinase"
REACT:R-HSA-8848606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates PXN (Homo sapiens)
REACT:R-GGA-1433514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
REACT:R-SSC-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Sus scrofa)
REACT:R-SSC-5689544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds INO80 complex (Sus scrofa)
RHEA:57885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H2O + Na(+)(in) => H(+) + Na(+)(out) + 2 phosphate
REACT:R-RNO-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Rattus norvegicus)
REACT:R-DDI-6811504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)
RHEA:38179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-2022378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Canis familiaris)
RHEA:21614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + H2O => D-gluconate
GO:0046568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutyraldehyde reductase activity
GO:0046568	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methylbutanal reductase [NAD(P)] activity
GO:0046568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol:NAD(P) oxidoreductase activity
GO:0046568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoamyl alcohol oxidase activity
RHEA:36893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + AH2 + O2
RHEA:30833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
RHEA:69098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-kynurenine
GO:1901981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol phosphate binding
REACT:R-SSC-5661121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Sus scrofa)
RHEA:54133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)
RHEA:33165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-riboside(out) => beta-nicotinamide D-riboside(in)
RHEA:24083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tryptophan + tRNA(Trp) <=> AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)
REACT:R-XTR-549297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-DME-2022911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSPG is secreted (Drosophila melanogaster)
RHEA:67886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+) => 3'-phosphoadenylyl sulfate + dopamine
RHEA:25035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)
REACT:R-SSC-193424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
REACT:R-DME-209181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARM displaces GRO and binds to PAN which activates transcription (Drosophila melanogaster)
RHEA:14726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate
RHEA:56711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Drosophila melanogaster)
RHEA:38480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine
REACT:R-HSA-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
RHEA:33744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine 1-phosphate + H2O => an N-acylsphing-4-enine + phosphate
RHEA:31798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(E)-beta-caryophyllene + H2O <=> (+)-caryolan-1-ol
RHEA:68894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 3-methoxybenzoate + ATP + H(+) + NADPH
REACT:R-SSC-5654640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)
RHEA:33229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxystyrene + CO2 => (E)-4-coumarate + H(+)
REACT:R-CFA-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Canis familiaris)
RHEA:22036	skos:prefLabel	"polyphosphate--glucose phosphotransferase"
RHEA:22036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polyphosphate--glucose phosphotransferase"
RHEA:22036	skos:altLabel	"polyphosphate glucokinase"
RHEA:22036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + D-glucose = [phosphate](n-1) + D-glucose 6-phosphate + H(+)
REACT:R-SSC-2545203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cleaved cohesin (Sus scrofa)
RHEA:29222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + sn-glycerol 3-phosphate <=> a menaquinol + dihydroxyacetone phosphate
RHEA:32151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate = (12E)-9alpha-labda-8(17),12,14-triene + diphosphate
RHEA:32151	skos:prefLabel	"labdatriene synthase"
RHEA:32151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"labdatriene synthase"
REACT:R-HSA-1028815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta (Homo sapiens)
RHEA:29675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol(in) = glycerol(out)
REACT:R-CFA-194689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Canis familiaris)
REACT:R-SCE-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Saccharomyces cerevisiae)
REACT:R-CFA-981814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC2 transfers sialic acid to Core 1 mucins (Canis familiaris)
RHEA:60814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A12 + H(+) + succinate => 2-oxoglutarate + gibberellin A12 aldehyde + O2
RHEA:54368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H(+) + pyruvate = acetoin + CO2
REACT:R-HSA-9604834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
REACT:R-SCE-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Saccharomyces cerevisiae)
RHEA:68090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase] => a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]
RHEA:58038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-epi-inunolide + H2O => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)
REACT:R-SSC-71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Sus scrofa)
REACT:R-DRE-3371554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 acetylation at Lys80 (Danio rerio)
RHEA:60624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine
REACT:R-HSA-8939900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)
REACT:R-DME-3132759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds RCbl (Drosophila melanogaster)
REACT:R-BTA-216727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Bos taurus)
RHEA:57915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) <=> H(+) + L-glutaminyl-tRNA(Gln) + phosphate
REACT:R-CFA-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)
REACT:R-GGA-446648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Gallus gallus)
REACT:R-MMU-5696838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Mus musculus)
RHEA:68199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoylglycerol + tetradecanoyl-CoA <=> 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA
REACT:R-GGA-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Gallus gallus)
RHEA:29703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine(in) = L-valine(out)
REACT:R-HSA-9702997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linafinib-resistant FLT3 mutants don't bind linifanib (Homo sapiens)
RHEA:12638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP
REACT:R-GGA-8865994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds PTPN11 (Gallus gallus)
RHEA:36748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:71143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhispidin + O2 = (E)-caffeoylpyruvate + CO2 + hnu
REACT:R-HSA-9616110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1-dependent CDK5R1 gene expression (Homo sapiens)
EC:3.4.24.74	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fragilysin"
EC:3.4.24.74	skos:altLabel	"Bacteroides fragilis enterotoxin"
EC:3.4.24.74	skos:prefLabel	"fragilysin"
REACT:R-BTA-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Bos taurus)
RHEA:21743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate
REACT:R-GGA-4570489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO2 (Gallus gallus)
REACT:R-GGA-205238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 interacts with p-KIT (Gallus gallus)
RHEA:25629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin + S-adenosyl-L-methionine = H(+) + laricitrin + S-adenosyl-L-homocysteine
REACT:R-XTR-8849881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM2 associate with AMPA and NMDA receptors (Xenopus tropicalis)
GO:0005221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular cyclic nucleotide activated cation channel activity
GO:0005221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Homo sapiens)
REACT:R-RNO-5689085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds polyUb-PARK2 (Rattus norvegicus)
REACT:R-HSA-9633008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
RHEA:70886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) <=> H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)
RHEA:16391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + hydroquinone + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH + O2
REACT:R-RNO-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Rattus norvegicus)
REACT:R-BTA-4755411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates IKBKG with SUMO1 (Bos taurus)
REACT:R-XTR-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Xenopus tropicalis)
REACT:R-RNO-9033520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves TYSND1 (Rattus norvegicus)
REACT:R-HSA-8874079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated MET (Homo sapiens)
RHEA:72096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine(out) + Na(+)(out) => (S)-carnitine(in) + Na(+)(in)
REACT:R-DRE-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Danio rerio)
REACT:R-HSA-3249392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)
RHEA:44870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phosphoethanol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol
REACT:R-XTR-77591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Xenopus tropicalis)
REACT:R-MMU-9700149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds PLCG1 (Mus musculus)
RHEA:56895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose <=> NADP(+) + UDP-beta-L-rhamnose
EC:5.4.2.5	skos:altLabel	"glucose phosphomutase"
EC:5.4.2.5	skos:prefLabel	"phosphoglucomutase (glucose-cofactor)"
EC:5.4.2.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglucomutase (glucose-cofactor)"
EC:5.4.2.5	skos:altLabel	"glucose-1-phosphate phosphotransferase"
REACT:R-MMU-77592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Intronless Pre-mRNA at 3'-end (Mus musculus)
REACT:R-HSA-9704408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C (Homo sapiens)
RHEA:25306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O
EC:3.4.22.54	skos:prefLabel	"calpain-3"
EC:3.4.22.54	skos:altLabel	"muscle-specific calcium-activated neutral protease 3"
EC:3.4.22.54	skos:altLabel	"calpain L3"
EC:3.4.22.54	skos:altLabel	"calcium-activated neutral proteinase 3"
EC:3.4.22.54	skos:altLabel	"CANP 3"
EC:3.4.22.54	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"calpain-3"
EC:3.4.22.54	skos:altLabel	"CAPN3"
EC:3.4.22.54	skos:altLabel	"calpain p94"
REACT:R-MMU-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Mus musculus)
GO:0008872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucarate hydro-lyase activity
GO:0008872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)
GO:0008872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucarate dehydratase activity
GO:0008872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucarate dehydratase activity
RHEA:21673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine
REACT:R-HSA-8875374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds LRIG1 (Homo sapiens)
REACT:R-DRE-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Danio rerio)
RHEA:59643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotetraose + O2 <=> D-xylotetraono-1,5-lactone + H2O2
RHEA:13912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + urate D-ribonucleoside <=> alpha-D-ribose 1-phosphate + urate
REACT:R-GGA-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)
RHEA:25372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + FMN => 3-(1-carboxyvinyloxy)anthranilate + FMNH2
REACT:R-HSA-374667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with SIAH2 (Homo sapiens)
RHEA:16457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH
REACT:R-SCE-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Saccharomyces cerevisiae)
REACT:R-HSA-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Homo sapiens)
REACT:R-CFA-9021357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCI phosphorylates ELF3 (Canis familiaris)
REACT:R-DME-5138459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A:FZD4 is endocytosed (Drosophila melanogaster)
REACT:R-HSA-9653724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcription of ATF5 (Homo sapiens)
REACT:R-BTA-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
RHEA:25805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermine => 3-aminopropanal + H2O2 + spermidine
REACT:R-XTR-1169192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B dephosphorylates GHR (Xenopus tropicalis)
RHEA:29333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(out) + 2 H(+)(out) => fumarate(in) + 2 H(+)(in)
RHEA:35751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + kanosamine = ADP + D-kanosamine 6-phosphate + H(+)
RHEA:35751	skos:prefLabel	"kanosamine kinase"
RHEA:35751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kanosamine kinase"
RHEA:63832	skos:prefLabel	"capsaicin synthase"
RHEA:63832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"capsaicin synthase"
RHEA:63832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-methylnon-6-enoyl-CoA + vanillylamine = capsaicin + CoA + H(+)
REACT:R-BTA-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Bos taurus)
RHEA:51844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
REACT:R-DRE-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Danio rerio)
REACT:R-HSA-8848975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS1 (Homo sapiens)
RHEA:43421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-MMU-141367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylation of tBID by NMT1 (Mus musculus)
RHEA:19665	skos:prefLabel	"pimeloyl-CoA dehydrogenase"
RHEA:19665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-CoA + NAD(+) = 6-carboxyhex-2-enoyl-CoA + H(+) + NADH
RHEA:19665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pimeloyl-CoA dehydrogenase"
REACT:R-RNO-2172123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SIGLEC14/15/16 and DAP12 (Rattus norvegicus)
REACT:R-XTR-976768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3b (Xenopus tropicalis)
RHEA:19641	skos:prefLabel	"4-coumarate--CoA ligase"
RHEA:19641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-coumarate--CoA ligase"
RHEA:19641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphate
RHEA:19641	skos:altLabel	"4-coumaryl-CoA synthetase"
RHEA:19641	skos:altLabel	"4-coumaroyl-CoA synthase"
REACT:R-DRE-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Danio rerio)
RHEA:44838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NOR2 (d18:1(4E)) + H(+) + UDP => globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose
RHEA:33107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + gamma-muurolene
RHEA:33107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-muurolene synthase"
RHEA:33107	skos:prefLabel	"gamma-muurolene synthase"
REACT:R-XTR-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Xenopus tropicalis)
GO:0004491	skos:altLabel	"MMSA dehydrogenase"
GO:0004491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA
GO:0004491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
GO:0004491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MMSA dehydrogenase activity
GO:0004491	skos:prefLabel	"methylmalonate-semialdehyde dehydrogenase (CoA acylating)"
GO:0004491	skos:altLabel	"MSDH"
GO:0004491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MSDH activity
GO:0004491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0004491	skos:altLabel	"methylmalonate-semialdehyde dehydrogenase (acylating)"
GO:0004491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylmalonate-semialdehyde dehydrogenase (CoA acylating)"
GO:0050618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin:ferredoxin oxidoreductase activity
GO:0050618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PebB
GO:0050618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity
RHEA:50960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine
RHEA:48927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine
REACT:R-BTA-6785821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS5,(SOCS1) bind IL4RA (Bos taurus)
REACT:R-DME-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Drosophila melanogaster)
REACT:R-MMU-6795667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the cytosol (Mus musculus)
REACT:R-SSC-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Sus scrofa)
REACT:R-CFA-8874705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Canis familiaris)
REACT:R-HSA-5610757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2 is degraded by the proteasome (Homo sapiens)
RHEA:15291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-xylan](n+1) + H(+) + UDP => [(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose
RHEA:47087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-methionine
RHEA:35520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine
REACT:R-RNO-450499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B (AKT) phosphorylates KSRP (Rattus norvegicus)
RHEA:46136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminopyrrolnitrin + H(+) + NADPH + 2 O2 = 2 H2O + NADP(+) + pyrrolnitrin
REACT:R-RNO-8849891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-3 bind to PSD-95 family members (Rattus norvegicus)
REACT:R-DRE-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Danio rerio)
REACT:R-DME-382053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDGF from ER to Golgi (Drosophila melanogaster)
REACT:R-CFA-5649673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyA from damaged DNA (Canis familiaris)
REACT:R-CFA-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Canis familiaris)
RHEA:52809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine in U6 snRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine
GO:0019901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase binding
GO:0034319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol O-butanoyltransferase activity
REACT:R-HSA-1671687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR activation (Homo sapiens)
REACT:R-SSC-9691421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK binds BTK inhibitors (Sus scrofa)
RHEA:35690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetradecasphinganine <=> 3-oxotetradecasphinganine + H(+) + NADPH
RHEA:29240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + uracil(in) => H(+)(out) + uracil(out)
REACT:R-HSA-1977959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with EGFR (Homo sapiens)
REACT:R-CFA-170964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 binds to active TrkA receptor (Canis familiaris)
REACT:R-CEL-8851804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET recruits GRB2-1:SOS1 (Caenorhabditis elegans)
RHEA:24008	skos:prefLabel	"hypotaurocyamine kinase"
RHEA:24008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hypotaurocyamine kinase"
RHEA:24008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hypotaurocyamine = ADP + H(+) + N(omega)-phosphohypotaurocyamine
RHEA:12025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-sinapoyl)-beta-D-glucose + choline => D-glucose + O-sinapoylcholine
REACT:R-MMU-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)
REACT:R-HSA-2090038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses heparan chain(2) (Homo sapiens)
RHEA:72222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 hydrogencarbonate(out) + Na(+)(out) <=> 3 hydrogencarbonate(in) + Na(+)(in)
RHEA:58575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-15alpha-stemmadenine + O2 <=> H2O2 + precondylocarpine acetate
RHEA:13370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate => diphosphate + isoprene
REACT:R-DME-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Drosophila melanogaster)
RHEA:62069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose 6-phosphate + NADP(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
RHEA:47038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine in 5S rRNA => uridine in 5S rRNA
RHEA:65952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)
RHEA:48732	skos:altLabel	"metallocarboxypeptidase Mec"
RHEA:48732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[CysO sulfur-carrier protein]-S-L-cysteine hydrolase"
RHEA:48732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O = [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine
RHEA:48732	skos:altLabel	"[CysO]-cysteine peptidase"
RHEA:48732	skos:prefLabel	"[CysO sulfur-carrier protein]-S-L-cysteine hydrolase"
REACT:R-HSA-2394007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
REACT:R-CEL-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
REACT:R-RNO-2454113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 transports 11cRAL to rod photoreceptor outer segment (Rattus norvegicus)
REACT:R-CFA-3965450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits PFN1 (Canis familiaris)
RHEA:46779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:65342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-acetyl-L-threonyl-[protein] => acetyl-CoA + L-threonyl-[protein]
REACT:R-CEL-6803892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds BAX (Caenorhabditis elegans)
REACT:R-BTA-2028651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Bos taurus)
REACT:R-HSA-975880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)
GO:0061543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-6 3-O-methyltransferase activity
REACT:R-DDI-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)
REACT:R-SSC-8854981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 in the RET complex is phosphorylated (Sus scrofa)
REACT:R-CEL-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Caenorhabditis elegans)
RHEA:23871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1-hydroxycyclohexan-1-yl)acetyl-CoA <=> acetyl-CoA + cyclohexanone
REACT:R-CFA-5665727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds CDC42:GTP (Canis familiaris)
GO:0047625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine = homoserine lactone + S-methyl-5'-thioadenosine
GO:0047625	skos:prefLabel	"adenosylmethionine cyclotransferase"
GO:0047625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylmethionine cyclotransferase"
GO:0047625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylmethionine cyclotransferase activity
GO:0047625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosyl methionine cyclotransferase activity
GO:0047625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine alkyltransferase (cyclizing)
GO:0047625	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylmethioninase activity
REACT:R-XTR-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Xenopus tropicalis)
RHEA:40570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 <=> A + dTDP-beta-L-evernitrose + H2O
RHEA:70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-ethylphenol
RHEA:55835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0047292	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity
GO:0047292	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity
GO:0047292	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity
GO:0047292	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity
GO:0047292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trihydroxypterocarpan dimethylallyltransferase activity
GO:0008418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N-terminal asparagine amidohydrolase activity
REACT:R-GGA-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Gallus gallus)
REACT:R-BTA-140777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Bos taurus)
RHEA:28413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH
REACT:R-MMU-170964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 binds to active TrkA receptor (Mus musculus)
RHEA:46346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-2-methylhexadecanoyl-CoA + CoA => propanoyl-CoA + tetradecanoyl-CoA
RHEA:68140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-hexanedione + 2 H(+) + 2 NADPH = (2R,5R)-hexanediol + 2 NADP(+)
RHEA:51504	skos:prefLabel	"2-hydroxyflavanone C-glucosyltransferase"
RHEA:51504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose = a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP
RHEA:51504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyflavanone C-glucosyltransferase"
REACT:R-CEL-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Caenorhabditis elegans)
REACT:R-SPO-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)
REACT:R-XTR-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Xenopus tropicalis)
RHEA:59803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-GGA-4085087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Gallus gallus)
REACT:R-SSC-429992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARN deadenylates mRNA (Sus scrofa)
REACT:R-CFA-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Canis familiaris)
REACT:R-CFA-9677579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Canis familiaris)
RHEA:14983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADPH => NADP(+) + testosterone
REACT:R-SSC-2428922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Sus scrofa)
REACT:R-MMU-2160915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor-mediated uptake of HA (Mus musculus)
REACT:R-CFA-2467798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTTG1 (Securin) sequesters ESPL1 (Separase) (Canis familiaris)
REACT:R-HSA-177933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by phosphorylated EGFR (Homo sapiens)
REACT:R-DRE-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Danio rerio)
REACT:R-HSA-4086216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII binds integrin alpha2beta1 (Homo sapiens)
GO:0015220	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	amino acid/choline transmembrane transporter activity
GO:0015220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)
GO:0015220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline transmembrane transporter activity
GO:0015220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline permease activity
RHEA:56038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)
RHEA:37637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine
REACT:R-MMU-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Mus musculus)
RHEA:14188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + H(+) <=> 2-phenylacetaldehyde + CO2
RHEA:28425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + ubiquinone-8 = iminosuccinate + ubiquinol-8
REACT:R-DME-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Drosophila melanogaster)
RHEA:38576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)
REACT:R-HSA-9603419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds SRC (Homo sapiens)
REACT:R-XTR-9688831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK3 at K55, K363 (Xenopus tropicalis)
RHEA:72585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH => (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+)
REACT:R-HSA-8874208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)
REACT:R-SSC-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Sus scrofa)
EC:2.7.7.36	skos:altLabel	"sugar-1-phosphate adenylyltransferase"
EC:2.7.7.36	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldose-1-phosphate adenylyltransferase"
EC:2.7.7.36	skos:altLabel	"ADP-aldose phosphorylase"
EC:2.7.7.36	skos:altLabel	"ADP-sugar phosphorylase"
EC:2.7.7.36	skos:prefLabel	"aldose-1-phosphate adenylyltransferase"
REACT:R-DDI-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Dictyostelium discoideum)
RHEA:22709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-acylglutathione => a carboxylate + glutathione + H(+)
RHEA:37956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate
REACT:R-DME-77584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Drosophila melanogaster)
REACT:R-SSC-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Sus scrofa)
RHEA:47564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GA2 (d18:1(4E)) + H(+) + UDP
RHEA:52579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + NAD(+) <=> (2E)-hexenoyl-CoA + H(+) + NADH
REACT:R-SCE-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Saccharomyces cerevisiae)
RHEA:62490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:16988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate + NADP(+) <=> H(+) + maleylacetate + NADPH
GO:0005549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant binding
REACT:R-HSA-192475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Homo sapiens)
RHEA:40276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanedioyl-CoA + O2 => (2E)-hexadecenedioyl-CoA + H2O2
REACT:R-HSA-8936608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
REACT:R-GGA-158311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Gallus gallus)
REACT:R-CEL-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Caenorhabditis elegans)
REACT:R-CFA-448632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimerizes (Canis familiaris)
REACT:R-DDI-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Dictyostelium discoideum)
REACT:R-DME-429698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKD1,2,3 phosphorylates CERT1-2 (Drosophila melanogaster)
RHEA:67466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine => H2O + propanoyl-CoA
REACT:R-DRE-5654603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS3 (Danio rerio)
RHEA:71922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + succinate(out) <=> 3 Na(+)(in) + succinate(in)
REACT:R-SSC-9029517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Sus scrofa)
RHEA:60788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A24 + H(+) + O2 = CO2 + gibberellin A9 + H2O
RHEA:57936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopyridoxal dehydrogenase (5-pyridoxate-forming)"
RHEA:57936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopyridoxal + NAD(+) = 5-pyridoxate + 2 H(+) + NADH
RHEA:57936	skos:prefLabel	"isopyridoxal dehydrogenase (5-pyridoxate-forming)"
REACT:R-CFA-377641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
RHEA:57569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:34852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxyadipyl-CoA + NAD(+) => 3-oxoadipyl-CoA + H(+) + NADH
GO:0008883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamyl-tRNA reductase activity
GO:0008883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)
RHEA:23158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetonitrile + H2O => (E)-(indol-3-yl)acetaldehyde oxime
RHEA:58404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + NADP(+) = H(+) + hexanal + NADPH
RHEA:13308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + UDP-alpha-D-glucose <=> 1-O-(trans-sinapoyl)-beta-D-glucose + UDP
RHEA:70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in) => H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out)
RHEA:15947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose 6-phosphate + L-lysyl-[protein]
RHEA:44596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + H2O = a fatty acid + H(+) + holo-[ACP]
REACT:R-MMU-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Mus musculus)
REACT:R-HSA-3791295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan degradation by MMP1,2,3,7,9,12,13 (Homo sapiens)
REACT:R-DRE-6797803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds SLITRK1-6 (Danio rerio)
RHEA:51454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate
RHEA:21981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)
RHEA:65474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + ethyl 2-methylbutanoate => 2-methylbutanoyl-CoA + ethanol
REACT:R-SSC-2162019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to EXA4 by ALOX15 (Sus scrofa)
RHEA:45234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH
REACT:R-GGA-5607732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TAK1 autophosphorylates (Gallus gallus)
RHEA:35725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + CoA => hexadecanoyl-CoA + sn-glycerol 3-phosphate
REACT:R-HSA-5357831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD is phosphorylated by IKK (Homo sapiens)
REACT:R-HSA-8938930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF2 (Homo sapiens)
REACT:R-CFA-201423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI complexes with the Smad complex, suppressing BMP2 signalling (Canis familiaris)
REACT:R-BTA-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Bos taurus)
REACT:R-BTA-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
REACT:R-XTR-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Xenopus tropicalis)
RHEA:28746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(in) + nitrite(out) <=> nitrate(out) + nitrite(in)
REACT:R-BTA-8985914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Bos taurus)
REACT:R-HSA-8855617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Homo sapiens)
RHEA:49266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + H(+) + shikimate => 5-O-[(E)-caffeoyl]-shikimate + H2O
REACT:R-BTA-198513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Bos taurus)
REACT:R-XTR-173481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Xenopus tropicalis)
GO:0106435	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	B-esterase activity
GO:0106435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nonspecific carboxylesterase activity
GO:0106435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxylesterase activity
GO:0106435	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serine esterase activity
GO:0106435	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	triacetin esterase
GO:0106435	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-carboxylesterase activity
GO:0106435	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin A esterase
GO:0106435	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cocaine esterase
GO:0106435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ali-esterase activity
GO:0106435	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	procaine esterase
GO:0042392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine-1-phosphate phosphatase activity
GO:0042392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine-1-phosphate phosphohydrolase activity
GO:0042392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP phosphatase activity
GO:0042392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPPase activity
REACT:R-CFA-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Canis familiaris)
REACT:R-SSC-8856525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANGPTL8 binds ANGPTL3 (Sus scrofa)
RHEA:70720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) => L-alanine(out)
RHEA:16192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + O2 <=> CO2 + homogentisate
RHEA:68762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine => 3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine
RHEA:16251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 6-phosphate => alpha-D-glucose 6-phosphate
GO:0004017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:AMP phosphotransferase activity
GO:0004017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylokinase activity
GO:0004017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylate kinase activity
GO:0004017	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myokinase activity
GO:0004017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-AMP-kinase activity
GO:0004017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylic kinase activity
GO:0038036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P receptor activity
GO:0038036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine-1-phosphate receptor activity
REACT:R-BTA-9619376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK1 binds calmodulin (Bos taurus)
RHEA:68263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(in) + Na(+)(in) <=> D-serine(out) + Na(+)(out)
RHEA:55658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carotenoid chi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative
RHEA:17282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-4-acetamido-2-aminobutanoate => H2O + L-ectoine
REACT:R-GGA-163090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation Of The Telomeric Chromosome End (Gallus gallus)
REACT:R-DRE-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Danio rerio)
RHEA:60666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + phosphate => H2O + NADPH
REACT:R-RNO-622420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Rattus norvegicus)
RHEA:31073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-2-methylpropanoate + pyruvate => (S)-methylmalonate semialdehyde + L-alanine
REACT:R-SPO-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Schizosaccharomyces pombe)
REACT:R-CFA-159790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Canis familiaris)
REACT:R-XTR-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Xenopus tropicalis)
REACT:R-CFA-2130640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of clathrin coated vesicle by Ii (Canis familiaris)
REACT:R-CFA-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Canis familiaris)
REACT:R-HSA-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Homo sapiens)
REACT:R-DRE-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Danio rerio)
REACT:R-RNO-170055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Rattus norvegicus)
REACT:R-BTA-8963851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 dissociates from GC (Bos taurus)
REACT:R-DME-377186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)
GO:0038177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	death receptor agonist activity
GO:0038177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	death receptor activator activity
REACT:R-GGA-5682588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 binds phosphorylated MDC1 at DNA DSBs (Gallus gallus)
REACT:R-RNO-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Rattus norvegicus)
RHEA:67862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]
RHEA:10579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + N-methylethanolamine phosphate <=> CDP-N-methylethanolamine + diphosphate
RHEA:54023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + propanoyl-CoA <=> CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]
REACT:R-HSA-9606162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)
REACT:R-HSA-8855915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Homo sapiens)
REACT:R-CFA-176669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Canis familiaris)
RHEA:18138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) => 5alpha-pregnane-3,20-dione + H(+) + NADPH
REACT:R-BTA-6798258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTPRF, PTPRS, PTPRD bind LRRC4B (Bos taurus)
REACT:R-SCE-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Saccharomyces cerevisiae)
REACT:R-HSA-8983996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)
RHEA:34592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-7 + S-adenosyl-L-methionine => Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-9708525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1:FBXL17 binds SCF(SKP2) complex (Drosophila melanogaster)
RHEA:51045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate imine dimer => CO2 + NH4(+) + protodeoxyviolaceinate
RHEA:52278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + vanillate
REACT:R-BTA-5688834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds VCP (Bos taurus)
RHEA:69066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline => N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2
RHEA:36981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA
RHEA:58081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-docosanoylglycerol + H2O => docosanoate + glycerol + H(+)
RHEA:70443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate
RHEA:40214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanedioyl-CoA + NAD(+) <=> 3-oxotetradecanedioyl-CoA + H(+) + NADH
RHEA:41404	skos:prefLabel	"2-methyl-1-pyrroline reductase"
RHEA:41404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-methylpyrrolidine + NADP(+) = 2-methyl-1-pyrroline + H(+) + NADPH
RHEA:41404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methyl-1-pyrroline reductase"
RHEA:41404	skos:altLabel	"(R)-imine reductase"
RHEA:17286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP
RHEA:20227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + H(+) + S-adenosyl-L-homocysteine => (E)-caffeate + S-adenosyl-L-methionine
REACT:R-DRE-193072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
RHEA:70961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => D-tyrosine + H2O + O2
REACT:R-HSA-5577050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Homo sapiens)
RHEA:35069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine(in) => (S)-carnitine(out)
REACT:R-PFA-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Plasmodium falciparum)
RHEA:60200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-trimethyl-L-lysine(9) demethylase"
RHEA:60200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate
RHEA:60200	skos:prefLabel	"[histone H3]-trimethyl-L-lysine(9) demethylase"
RHEA:56252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP
RHEA:50915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol <=> 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)
REACT:R-RNO-211919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F8 19-hydroxylates PGH2 (Rattus norvegicus)
REACT:R-HSA-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Homo sapiens)
RHEA:64189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-tyrosine + H2O => a fatty acid + L-tyrosine
GO:0052862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group
GO:0052862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-(1,4)-beta-D-glucan 4-glucanohydrolase activity
GO:0052862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	laminaranase activity
GO:0052862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	laminarinase activity
RHEA:35188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-aminoperacrylic acid + AH2 => (Z)-3-aminoacrylate + A + H(+) + H2O
RHEA:50731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(4-hydroxyphenyl)acetaldehyde oxime <=> 4-hydroxyphenylacetonitrile + H2O
GO:0004857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme inhibitor activity
GO:0004857	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloenzyme inhibitor activity
RHEA:70134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-2428922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Canis familiaris)
REACT:R-DRE-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Danio rerio)
EC:7.6.2.14	skos:altLabel	"aliphatic sulfonate ABC transporter"
EC:7.6.2.14	skos:altLabel	"aliphatic sulfonate transporting ATPase"
EC:7.6.2.14	skos:altLabel	"alkane sulfonate ABC transporter"
EC:7.6.2.14	skos:prefLabel	"ABC-type aliphatic sulfonate transporter"
EC:7.6.2.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type aliphatic sulfonate transporter"
REACT:R-RNO-199032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADCAM1-1 binds Integrin alpha4beta7 (Rattus norvegicus)
REACT:R-HSA-9717206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Homo sapiens)
REACT:R-RNO-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Rattus norvegicus)
REACT:R-HSA-5666178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTKN binds RHOA, RHOC or RHOB (Homo sapiens)
REACT:R-RNO-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Rattus norvegicus)
RHEA:47067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-1250280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin (Homo sapiens)
REACT:R-GGA-9653595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B binds BCL2L1 (Gallus gallus)
RHEA:19241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2
RHEA:24943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADPH
REACT:R-MMU-6798374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DYRK2 phosphorylates TP53 (Mus musculus)
RHEA:30577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 menaquinol-8 + protoporphyrin IX => 3 menaquinone-8 + protoporphyrinogen IX
REACT:R-HSA-9683488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 is glycosylated to glycosylated-ACE2 (Homo sapiens)
REACT:R-GGA-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Gallus gallus)
REACT:R-SSC-1504186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL recruits GSK3beta:AXIN1 to the receptor complex (Sus scrofa)
REACT:R-HSA-9729704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 3CLpro dimer cleaves TAB1 (Homo sapiens)
REACT:R-BTA-9661408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Bos taurus)
REACT:R-SSC-9026003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Sus scrofa)
REACT:R-SSC-1250353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Sus scrofa)
RHEA:67730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + DNA(n)-Z => DNA(n) + dZTP
RHEA:13172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleate <=> fumarate
REACT:R-MMU-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Mus musculus)
RHEA:38012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a + H2O => chlorophyllide a + H(+) + phytol
RHEA:35271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-CEL-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Caenorhabditis elegans)
RHEA:50712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetracycline 7-halogenase"
RHEA:50712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + O2 + tetracycline = 7-chlorotetracycline + FAD + H(+) + 2 H2O
RHEA:50712	skos:prefLabel	"tetracycline 7-halogenase"
RHEA:65429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deamido-NAD(+)(in) + NAD(+)(out) => deamido-NAD(+)(out) + NAD(+)(in)
RHEA:17510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine => 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)
RHEA:68878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + NADP(+) + piperonal => ATP + H(+) + NADPH + piperonylate
REACT:R-RNO-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Rattus norvegicus)
RHEA:34814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetrahydrocurcumin <=> dihydrocurcumin + H(+) + NADPH
RHEA:55644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] = ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate
RHEA:14682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-aminophenol + A + O2 => 2-aminophenoxazin-3-one + AH2 + 2 H2O
RHEA:64086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+)
REACT:R-HSA-2130282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
GO:0050610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:methylarsonate oxidoreductase activity
GO:0050610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylarsonate reductase activity
GO:0050610	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MMA(V) reductase activity
GO:0050610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO1 dimer reduces methylarsonate to methylarsonite (Homo sapiens)
RHEA:62881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 => (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A
RHEA:42279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA
RHEA:11985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + progesterone => A + H2O + testosterone acetate
REACT:R-CEL-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:13344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine
REACT:R-XTR-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Xenopus tropicalis)
REACT:R-MMU-9009282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates RUNX2 (Mus musculus)
REACT:R-HSA-5262606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling (Homo sapiens)
REACT:R-CFA-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Canis familiaris)
REACT:R-SSC-443402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Sus scrofa)
REACT:R-CFA-9697747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at TNFR signaling complex (Canis familiaris)
RHEA:11702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + testosterone acetate => H(+) + NADPH + O2 + progesterone
REACT:R-DDI-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Dictyostelium discoideum)
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestenone 5-alpha-reductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholest-4-en-3-one 5alpha-reductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	5alpha-reductase
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-ene-3-oxosteroid 5alpha-reductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxosteroid 5alpha-reductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 5alpha-hydrogenase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-oxosteroid delta4-dehydrogenase
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	testosterone delta4-5alpha-reductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid 5alpha-reductase
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta4-3-ketosteroid 5alpha-oxidoreductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	testosterone 5alpha-reductase
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestenone 5a-reductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-ene-5alpha-reductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholestenone 5alpha-reductase activity
GO:0047751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	testosterone delta4-hydrogenase activity
RHEA:13044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopachrome <=> 5,6-dihydroxyindole-2-carboxylate
RHEA:16968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> beta-myrcene + diphosphate
RHEA:54802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA => [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+)
GO:0031725	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CXCR6 chemokine receptor ligand
GO:0031725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bonzo receptor binding
GO:0031725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR6 chemokine receptor binding
GO:0031725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRL33 receptor binding
RHEA:55488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:18461	skos:altLabel	"acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase"
RHEA:18461	skos:prefLabel	"1-alkylglycerophosphocholine O-acetyltransferase"
RHEA:18461	skos:altLabel	"lyso-platelet activating factor:acetyl-CoA acetyltransferase"
RHEA:18461	skos:altLabel	"platelet-activating factor-synthesizing enzyme"
RHEA:18461	skos:altLabel	"acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase"
RHEA:18461	skos:altLabel	"1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase"
RHEA:18461	skos:altLabel	"lysoPAF:acetyl CoA acetyltransferase"
RHEA:18461	skos:altLabel	"blood platelet-activating factor acetyltransferase"
RHEA:18461	skos:altLabel	"platelet-activating factor acylhydrolase"
RHEA:18461	skos:altLabel	"PAF acetyltransferase"
RHEA:18461	skos:altLabel	"lyso-GPC:acetyl CoA acetyltransferase"
RHEA:18461	skos:altLabel	"1-alkyl-2-lysolecithin acetyltransferase"
RHEA:18461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
RHEA:18461	skos:altLabel	"lyso-platelet-activating factor:acetyl-CoA acetyltransferase"
RHEA:18461	skos:altLabel	"acetyl-CoA:lyso-PAF acetyltransferase"
RHEA:18461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-alkylglycerophosphocholine O-acetyltransferase"
RHEA:28517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + ATP + CoA <=> (R)-carnitinyl-CoA + AMP + diphosphate
EC:3.4.21.105	skos:prefLabel	"rhomboid protease"
EC:3.4.21.105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhomboid protease"
REACT:R-BTA-163741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Bos taurus)
REACT:R-DRE-450257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Danio rerio)
RHEA:50220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-demethyl-4-deoxygadusol = (R)-demethyl-4-deoxygadusol
REACT:R-SSC-1299297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of THIK (Sus scrofa)
RHEA:64213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-isoleucine + H2O => a fatty acid + L-isoleucine
RHEA:17031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + H(+) => (S)-allantoin + H2O
RHEA:52779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:19758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate
REACT:R-HSA-2997709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO1 (Homo sapiens)
REACT:R-XTR-211910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Xenopus tropicalis)
REACT:R-SSC-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Sus scrofa)
RHEA:60841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]
REACT:R-DDI-372519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcCho is hydrolyzed to Cho and acetate by ACHE (Dictyostelium discoideum)
REACT:R-HSA-141673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
RHEA:65559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside GalGb4Cer + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc
REACT:R-BTA-5138459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A:FZD4 is endocytosed (Bos taurus)
RHEA:31738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocholan-24-oyl-CoA + NAD(+) <=> 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
RHEA:66122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate => 2-oxobutanoate + L-methionine
REACT:R-GGA-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Gallus gallus)
REACT:R-DME-6810464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT14 hydrolyses UDP-Glc to G1P and UMP (Drosophila melanogaster)
REACT:R-DRE-191062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of Klotho-bound FGFR1c (Danio rerio)
REACT:R-HSA-6788628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dissociate (Homo sapiens)
REACT:R-GGA-8938829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Gallus gallus)
RHEA:31246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) <=> (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH
GO:1903135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copper(2+)binding
GO:1903135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(II) binding
GO:1903135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+) binding
GO:1903135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cupric ion binding
REACT:R-DME-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Drosophila melanogaster)
REACT:R-BTA-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Bos taurus)
RHEA:61128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + quercetin + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]
RHEA:61113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:2.8.5.2	skos:prefLabel	"L-cysteine S-thiosulfotransferase"
EC:2.8.5.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-cysteine S-thiosulfotransferase"
RHEA:38668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine 1-phosphate(in) => sphing-4-enine 1-phosphate(out)
RHEA:29593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NADP(+)
REACT:R-HSA-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Homo sapiens)
REACT:R-HSA-9666433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)
RHEA:22921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + scyllo-inosose => 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate
REACT:R-BTA-8848713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds BCAR1 (Bos taurus)
RHEA:48996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylcatechol + O2 = 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)
REACT:R-DRE-9647660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds PIPs (Danio rerio)
REACT:R-XTR-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Xenopus tropicalis)
RHEA:13238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate
GO:0098680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	template-free RNA nucleotidyltransferase
RHEA:23342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose + pyruvate => 3-deoxy-alpha-D-manno-oct-2-ulosonate
REACT:R-DME-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Drosophila melanogaster)
RHEA:31465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl crocetin + UDP => crocetin + UDP-alpha-D-glucose
REACT:R-RNO-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Rattus norvegicus)
REACT:R-XTR-390597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Xenopus tropicalis)
REACT:R-BTA-450133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP binds MYD88 homodimer (Bos taurus)
RHEA:27687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GDP => ADP + GTP
GO:0009675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity sulfate:proton symporter activity
GO:0009675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity sulfate:proton symporter activity
GO:0009675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity sulfate:hydrogen symporter activity
GO:0009675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity sulphate:hydrogen symporter activity
RHEA:33069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + phosphate => (4R)-hydroxysphinganine 1-phosphate + H2O
REACT:R-BTA-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Bos taurus)
REACT:R-DME-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Drosophila melanogaster)
REACT:R-RNO-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Rattus norvegicus)
REACT:R-SCE-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Saccharomyces cerevisiae)
RHEA:13043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroxyindole-2-carboxylate => L-dopachrome
RHEA:11773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH
REACT:R-MMU-5693539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of DNA and formation of Holliday structures following repair synthesis (Mus musculus)
RHEA:32412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,4S)-isodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH
RHEA:52857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine
GO:0047361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphomannan mannosephosphotransferase activity
GO:0047361	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:phosphomannan mannose phosphotransferase activity
REACT:R-HSA-9709360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 reduces MetHb (Homo sapiens)
RHEA:13965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L,L-cystathionine = L-homocysteine + NH4(+) + pyruvate
GO:0097748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5' RNA polymerase activity
GO:0097748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)
REACT:R-SSC-8848414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds CDKN1B (Sus scrofa)
REACT:R-DRE-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Danio rerio)
RHEA:39459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)
RHEA:55948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-alanine + H2O = AH2 + NH4(+) + pyruvate
RHEA:42118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)
REACT:R-SSC-452091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IL2RB Y338 enables SHC recruitment (Sus scrofa)
RHEA:20657	skos:prefLabel	"arylacetonitrilase"
RHEA:20657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH4(+)
RHEA:20657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arylacetonitrilase"
GO:0050371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine phenol-lyase activity
GO:0050371	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
GO:0050371	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-tyrosinase activity
GO:0050371	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine phenol-lyase (deaminating)
REACT:R-DRE-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Danio rerio)
REACT:R-XTR-5653766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)
RHEA:32296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH => 2 diphosphate + NADP(+) + squalene
REACT:R-DDI-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Dictyostelium discoideum)
REACT:R-DRE-2168885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin binds Hemoglobin (Danio rerio)
REACT:R-BTA-400434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds fatty acids (Bos taurus)
REACT:R-DME-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Drosophila melanogaster)
RHEA:17200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate + O2 <=> 2 4-hydroxyphenylacetate + 2 CO2
RHEA:15133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)
REACT:R-CFA-6781899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds SIAH2 (Canis familiaris)
REACT:R-GGA-1678921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length TLR3/7/8/9 binds to UNC93B1 (Gallus gallus)
RHEA:45950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] => acetyl-CoA + L-lysyl-[protein]
REACT:R-XTR-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Xenopus tropicalis)
RHEA:40632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trioctadecanoylglycerol => 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate
REACT:R-SSC-451418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates IRAK1 (Sus scrofa)
RHEA:61239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionine + O2 <=> 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)
REACT:R-CFA-5687112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 is degraded by the 26S proteasome (Canis familiaris)
REACT:R-BTA-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Bos taurus)
REACT:R-BTA-8871226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA2 (Bos taurus)
REACT:R-MMU-5218811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO binds CRK (Mus musculus)
REACT:R-HSA-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Homo sapiens)
REACT:R-DRE-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Danio rerio)
REACT:R-BTA-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Bos taurus)
REACT:R-BTA-914018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Bos taurus)
REACT:R-BTA-140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Bos taurus)
RHEA:69690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein 7-O-beta-D-glucoside + H2O <=> beta-D-glucose + genistein
RHEA:53249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-6784598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPPA(124-151) binds NPR1 (Bos taurus)
REACT:R-RNO-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Rattus norvegicus)
RHEA:29940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + phosphate(in) => H(+)(out) + phosphate(out)
REACT:R-CEL-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Caenorhabditis elegans)
RHEA:53581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:21550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-lysyl-[alpha-tubulin] => H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin]
RHEA:38388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)
GO:1905055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels
GO:1905055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
RHEA:43508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diformylfuran + H2O = 2-(dihydroxymethyl)-5-formylfuran
REACT:R-BTA-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Bos taurus)
RHEA:67843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid A disaccharide + ATP <=> a lipid IVA + ADP + H(+)
RHEA:33013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:72707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose(in) + GMP(out) = GDP-beta-L-fucose(out) + GMP(in)
REACT:R-XTR-2730841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV (Xenopus tropicalis)
GO:0061693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
REACT:R-MMU-5682586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 and PIAS4 are recruited to DNA DSBs (Mus musculus)
GO:0018515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pimeloyl-CoA dehydrogenase activity
GO:0018515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pimeloyl-CoA:NAD+ oxidoreductase activity
EC:3.4.21.108	skos:altLabel	"HtrA2 protease"
EC:3.4.21.108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"HtrA2 peptidase"
EC:3.4.21.108	skos:altLabel	"Omi stress-regulated endoprotease"
EC:3.4.21.108	skos:altLabel	"serine proteinase OMI"
EC:3.4.21.108	skos:altLabel	"high temperature requirement protein A2"
EC:3.4.21.108	skos:prefLabel	"HtrA2 peptidase"
REACT:R-HSA-390598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Homo sapiens)
RHEA:18036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:48136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate
REACT:R-SSC-5252072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AZGP1 binds PIP (Sus scrofa)
REACT:R-RNO-5218839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Rattus norvegicus)
REACT:R-RNO-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Rattus norvegicus)
GO:0038174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-17A receptor activity
REACT:R-MMU-2089971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of collagens (Mus musculus)
REACT:R-CFA-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Canis familiaris)
REACT:R-HSA-8865546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXP3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
RHEA:51173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
RHEA:69096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-kynurenine = H2O + kynurenate + L-methionine
REACT:R-BTA-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Bos taurus)
REACT:R-GGA-421482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylbilane => uroporphyrinogen III + H2O (Gallus gallus)
RHEA:18690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
REACT:R-RNO-5229273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCN2:2,5DHBA binds Fe3+ (Rattus norvegicus)
RHEA:33194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA
RHEA:64416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylofuranose + NADP(+) = D-xylono-1,4-lactone + H(+) + NADPH
RHEA:64416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,4-lactone-forming)"
RHEA:64416	skos:prefLabel	"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,4-lactone-forming)"
GO:0016941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	natriuretic peptide receptor activity
RHEA:28405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A
REACT:R-HSA-8871370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Homo sapiens)
RHEA:16056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine <=> H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP
GO:0102614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacrene A acid 8beta-hydroxylase activity
RHEA:39702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-(13Z)-eicosenoyl-CoA <=> (2E,13Z)-eicosadienoyl-CoA + H2O
REACT:R-XTR-2309779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer binds PTGS2 inhibitors (Xenopus tropicalis)
REACT:R-SPO-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Schizosaccharomyces pombe)
GO:0070917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IPC synthase regulator activity
GO:0070917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol phosphoceramide synthase regulator activity
REACT:R-HSA-1222353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protonation of superoxide (Homo sapiens)
EC:3.4.21.35	skos:prefLabel	"tissue kallikrein"
EC:3.4.21.35	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tissue kallikrein"
EC:3.4.21.35	skos:altLabel	"kininogenin"
EC:3.4.21.35	skos:altLabel	"glandular kallikrein"
REACT:R-GGA-5654147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PLCG1 (Gallus gallus)
RHEA:71958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + 3 Na(+)(out) <=> glutarate(in) + 3 Na(+)(in)
REACT:R-MMU-5662662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosinase oxidises tyrosine to dopaquinone (Mus musculus)
REACT:R-SPO-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Schizosaccharomyces pombe)
REACT:R-XTR-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Xenopus tropicalis)
RHEA:20424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltose 6'-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate
RHEA:34610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine <=> a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine
RHEA:44235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:14912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonate + NADP(+) <=> aldehydo-D-glucuronate + H(+) + NADPH
RHEA:69161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O + O2 => H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)
RHEA:16205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] = N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate
REACT:R-SSC-9653595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B binds BCL2L1 (Sus scrofa)
RHEA:71343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-histidine(out) + 2 Na(+)(out) = chloride(in) + L-histidine(in) + 2 Na(+)(in)
RHEA:44686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine
RHEA:59161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]
REACT:R-SSC-5607741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p52:RELB translocates from cytosol to nucleus (Sus scrofa)
REACT:R-SSC-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Sus scrofa)
REACT:R-MMU-8932955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-RNO-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Rattus norvegicus)
REACT:R-DDI-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Dictyostelium discoideum)
REACT:R-HSA-9706298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CSK (Homo sapiens)
REACT:R-DRE-156526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)
REACT:R-MMU-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Mus musculus)
RHEA:56553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[rhodopsin] => ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]
REACT:R-HSA-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Homo sapiens)
RHEA:57349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methyl-L-kynurenine + H2O => 3-hydroxy-4-methylanthranilate + H(+) + L-alanine
REACT:R-RNO-9606887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CD19:VAV binds PI3K and GRB2 (Rattus norvegicus)
REACT:R-SSC-5624951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNPO1 binds KIF17 dimer (Sus scrofa)
REACT:R-DME-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)
RHEA:13872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH
REACT:R-BTA-375342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 36 mediated neuronal gap junction communication (Bos taurus)
REACT:R-RNO-349638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of SR-BI-bound spherical HDL (Rattus norvegicus)
RHEA:29403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 = 3-demethylubiquinol-8 + A + H2O
REACT:R-DRE-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Danio rerio)
REACT:R-DME-8874470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Drosophila melanogaster)
RHEA:67901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate + succinyl-CoA => glutaryl-CoA + succinate
RHEA:72599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)
RHEA:61943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose <=> 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP
REACT:R-BTA-2032775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD1 (Bos taurus)
RHEA:10949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucosamine => ADP + D-glucosamine 6-phosphate + H(+)
GO:0043422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase B binding
GO:0043422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKB binding
GO:0043422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Akt binding
RHEA:65514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2 => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2
RHEA:55317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + hydrogen sulfide + 3 NAD(+) => 4 H(+) + 3 NADH + sulfite
EC:3.4.22.32	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stem bromelain"
EC:3.4.22.32	skos:altLabel	"bromelain"
EC:3.4.22.32	skos:prefLabel	"stem bromelain"
REACT:R-RNO-5672961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates inactive RAFs (Rattus norvegicus)
REACT:R-XTR-382054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binds to extracellular matrix proteins (Xenopus tropicalis)
RHEA:58839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-DRE-8853789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDNF,NRTN bind RET:GFRA1,GFRA2 (Danio rerio)
RHEA:21904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + H2O = (2R)-3-phosphoglycerate + phosphate
REACT:R-CFA-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Canis familiaris)
REACT:R-DME-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Drosophila melanogaster)
RHEA:17898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ethylbenzene + H2O => (S)-1-phenylethanol + AH2
REACT:R-DRE-5624133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3:GTP binds the UNC119B complex (Danio rerio)
REACT:R-RNO-5357757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC(cIAP1/2) ubiquitinates RIPK1 (Rattus norvegicus)
REACT:R-RNO-8849350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Rattus norvegicus)
REACT:R-HSA-2581488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAG binds p-MII to form p-MII:SAG (Homo sapiens)
REACT:R-DME-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Drosophila melanogaster)
REACT:R-BTA-110353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MBD4 glycosylase by APEX1 at the AP site (Bos taurus)
REACT:R-BTA-196026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dab2 is recruited to the junctional plaques (Bos taurus)
REACT:R-GGA-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Gallus gallus)
RHEA:24489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-3247569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADI4 deiminates Histones (Canis familiaris)
RHEA:42654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine
REACT:R-BTA-109343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Bos taurus)
REACT:R-RNO-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Rattus norvegicus)
REACT:R-SSC-1614461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetramerization of procollagen VI (Sus scrofa)
RHEA:50682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-glutamyl-[protein] + NH4(+) => H2O + N-terminal L-glutaminyl-[protein]
REACT:R-XTR-212004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Xenopus tropicalis)
RHEA:30131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoyl-[ACP] = H(+) + holo-[ACP] + octanoate
REACT:R-DRE-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Danio rerio)
REACT:R-CFA-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Canis familiaris)
RHEA:23662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formimidoyl-L-glutamate => 4-imidazolone-5-propanoate + H2O
RHEA:52728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate = a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)
RHEA:65127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + ethanol <=> benzyl acetate + CoA
REACT:R-CEL-3215385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Caenorhabditis elegans)
REACT:R-SSC-422104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase octanoylates Proghrelin (Sus scrofa)
REACT:R-GGA-434130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 binds to activated TLR5 or 15. (Gallus gallus)
RHEA:67851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate
REACT:R-MMU-190245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1b binds to FGF (Mus musculus)
REACT:R-RNO-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Rattus norvegicus)
RHEA:33051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + NAD(+) = betaine aldehyde + H(+) + NADH
REACT:R-SSC-5676917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Sus scrofa)
REACT:R-BTA-77614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR1) (Bos taurus)
REACT:R-RNO-190260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b binds to FGF (Rattus norvegicus)
GO:0016004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase activator activity
REACT:R-CFA-1296127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of voltage gated Potassium channels (Canis familiaris)
REACT:R-SSC-1475017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Sus scrofa)
RHEA:50916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + ATP + H(+) + NADPH = AMP + an aldehyde + diphosphate + NADP(+)
REACT:R-SSC-2396009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds c-di-GMP (Sus scrofa)
REACT:R-DRE-209765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
REACT:R-HSA-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)
REACT:R-MMU-8852324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds PLK1 (Mus musculus)
REACT:R-SSC-5669240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLNA binds PAK1 (Sus scrofa)
REACT:R-BTA-391168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP gamma binds CD47 (Bos taurus)
GO:0030234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalytic regulator activity
GO:0030234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme regulator activity
GO:0030234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme modulator
GO:0030234	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloenzyme regulator activity
RHEA:41165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-amino-sn-glycerol + ATP
REACT:R-SPO-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Schizosaccharomyces pombe)
RHEA:67838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-BTA-382055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb7 binds to the active PDGF receptor (Bos taurus)
REACT:R-DRE-159783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)
REACT:R-MMU-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Mus musculus)
RHEA:31104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydrofolate + NADP(+) => folate + H(+) + NADPH
REACT:R-SSC-173481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Sus scrofa)
REACT:R-BTA-8869606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)
RHEA:12505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH
REACT:R-DRE-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Danio rerio)
RHEA:44962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + NADP(+) => (2E)-decenoyl-CoA + H(+) + NADPH
RHEA:70054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate
REACT:R-DRE-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Danio rerio)
RHEA:18614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxybenzoate + AH2 + O2 => 4-hydroxybenzoate + A + formaldehyde + H2O
REACT:R-DRE-9013109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GEFs activate RHOC (Danio rerio)
RHEA:65971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate
REACT:R-DRE-937032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 (Danio rerio)
REACT:R-DRE-6791218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Danio rerio)
RHEA:60460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
RHEA:44900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactono-1,4-lactone + H2O = D-galactonate + H(+)
REACT:R-DRE-390251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Danio rerio)
REACT:R-RNO-2089971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of collagens (Rattus norvegicus)
RHEA:48779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-9629918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 translocates to the nucleus (Canis familiaris)
REACT:R-RNO-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Rattus norvegicus)
REACT:R-MMU-417927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y2 receptor binds ATP and UTP (Mus musculus)
REACT:R-DRE-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Danio rerio)
REACT:R-DME-8848215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Drosophila melanogaster)
REACT:R-DME-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Drosophila melanogaster)
REACT:R-HSA-8876255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin complex to InlB-bound MET (Homo sapiens)
REACT:R-SCE-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Saccharomyces cerevisiae)
GO:0005068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transmembrane receptor protein tyrosine kinase docking protein activity
GO:0005068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor protein tyrosine kinase adaptor protein activity
REACT:R-DME-9021072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC7, ZDHHC21 palmitoylate ESR1 (Drosophila melanogaster)
REACT:R-RNO-983696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Immunoglobulin of the BCR binds antigen (Rattus norvegicus)
REACT:R-SSC-5690080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP3,SAGA deubiquitinate Histone H2A,H2B (Sus scrofa)
REACT:R-BTA-418442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Bos taurus)
REACT:R-BTA-2428922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Bos taurus)
RHEA:48855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 <=> 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
REACT:R-SSC-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Sus scrofa)
REACT:R-MMU-8855648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM3 binds LAR-RPTP (Mus musculus)
REACT:R-MMU-202212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to LAT (Mus musculus)
RHEA:60305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:31671	skos:prefLabel	"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase"
RHEA:31671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase"
RHEA:31671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:63823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) <=> H(+) + holo-[aryl-carrier protein] + petrobactin
GO:0004057	skos:prefLabel	"arginyltransferase"
GO:0004057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginyl-tRNA protein transferase activity
GO:0004057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginyl-tRNA:protein arginyltransferase activity
GO:0004057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginyl-transfer ribonucleate-protein aminoacyltransferase activity
GO:0004057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginyltransferase activity
GO:0004057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginyl-transfer ribonucleate-protein transferase activity
GO:0004057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginyl-tRNA-protein transferase activity
GO:0004057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginyltransferase"
GO:0004057	skos:altLabel	"arginyl-tRNA--protein transferase"
GO:0004057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginyl-tRNA--protein transferase activity
GO:0004057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)
GO:0004057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine transferase activity
GO:0015279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	store-operated calcium channel activity
GO:0015279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
REACT:R-MMU-8987104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Mus musculus)
RHEA:23028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] = acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]
RHEA:23028	skos:prefLabel	"malonyl-S-ACP:biotin-protein carboxyltransferase"
RHEA:23028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malonyl-S-ACP:biotin-protein carboxyltransferase"
REACT:R-DRE-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Danio rerio)
REACT:R-GGA-917987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFRC dimer binds 2xholoTF (Gallus gallus)
RHEA:14614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurine(out) => ADP + H(+) + phosphate + taurine(in)
REACT:R-DDI-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)
RHEA:51162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine
REACT:R-DRE-6799178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 1 binds HP subcomplex to form Intermediate 2 (Danio rerio)
REACT:R-CFA-445113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Urotensin-2 receptor binds urotensin-2 and 2B (Canis familiaris)
REACT:R-DRE-1358791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of USP8 by P-AKT (Danio rerio)
REACT:R-GGA-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Gallus gallus)
RHEA:12797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6beta-hydroxyhyoscyamine epoxidase"
RHEA:12797	skos:altLabel	"hydroxyhyoscyamine dioxygenase"
RHEA:12797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + scopolamine + succinate
RHEA:12797	skos:prefLabel	"6beta-hydroxyhyoscyamine epoxidase"
REACT:R-HSA-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Homo sapiens)
RHEA:22449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pseudouridine => ADP + H(+) + psi-UMP
RHEA:66638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-alpha-acorenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-HSA-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Homo sapiens)
REACT:R-SPO-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Schizosaccharomyces pombe)
REACT:R-BTA-266089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Discoidal HDL binds membrane-associated free cholesterol (Bos taurus)
REACT:R-XTR-170044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Xenopus tropicalis)
RHEA:10292	skos:altLabel	"phosphoglucosamine transacetylase"
RHEA:10292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-glucosamine 6-phosphate = CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate
RHEA:10292	skos:altLabel	"phosphoglucosamine acetylase"
RHEA:10292	skos:altLabel	"aminodeoxyglucosephosphate acetyltransferase"
RHEA:10292	skos:altLabel	"glucosamine-6-phosphate acetylase"
RHEA:10292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosamine-phosphate N-acetyltransferase"
RHEA:10292	skos:altLabel	"glucosamine 6-phosphate N-acetyltransferase"
RHEA:10292	skos:altLabel	"phosphoglucosamine N-acetylase"
RHEA:10292	skos:altLabel	"D-glucosamine-6-P N-acetyltransferase"
RHEA:10292	skos:prefLabel	"glucosamine-phosphate N-acetyltransferase"
RHEA:10292	skos:altLabel	"glucosamine 6-phosphate acetylase"
RHEA:10292	skos:altLabel	"N-acetylglucosamine-6-phosphate synthase"
EC:1.3.99.5	skos:prefLabel	"3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)"
EC:1.3.99.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)"
EC:1.3.99.5	skos:altLabel	"steroid 5alpha-reductase"
REACT:R-HSA-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Homo sapiens)
RHEA:63276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-SSC-203156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-derived TREM-1 ligand binds to TREM-1 (Sus scrofa)
RHEA:68591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine <=> (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)
RHEA:17792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine <=> (S)-reticuline + H(+) + S-adenosyl-L-homocysteine
RHEA:43864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)
RHEA:53280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threose = D-erythrulose
REACT:R-HSA-72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of mRNA at the 3'-end (Homo sapiens)
REACT:R-DRE-193682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves the p75NTR transmembrane domain (Danio rerio)
REACT:R-CEL-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Caenorhabditis elegans)
RHEA:18711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + NH4(+) + sulfoacetaldehyde => A + H2O + taurine
REACT:R-SSC-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Sus scrofa)
RHEA:32836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate(in) => 4-(trimethylamino)butanoate(out)
REACT:R-GGA-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Gallus gallus)
REACT:R-HSA-9654792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GRB10 (Homo sapiens)
REACT:R-SSC-5633040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Sus scrofa)
RHEA:44311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:29815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-proline(out) = ADP + H(+) + L-proline(in) + phosphate
GO:0047441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-2-deoxyphosphogluconate aldolase activity
GO:0047441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-5-dehydro-2-deoxygluconate aldolase activity
GO:0047441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-5-keto-2-deoxygluconate aldolase activity
GO:0047441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity
GO:0047441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)
RHEA:65471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + acetyl-CoA <=> CoA + propyl acetate
RHEA:34820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocurcumin + NADP(+) => curcumin + H(+) + NADPH
REACT:R-MMU-2024084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS-GAGs translocate to the lysosome for degradation (Mus musculus)
REACT:R-CFA-9699579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of FLT3  (Canis familiaris)
GO:0004356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-ammonia ligase activity
GO:0004356	skos:prefLabel	"glutamine synthetase"
GO:0004356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate
GO:0004356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine synthetase activity
GO:0004356	skos:altLabel	"L-glutamine synthetase"
GO:0004356	skos:altLabel	"glutamate--ammonia ligase"
GO:0004356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamine synthetase"
GO:0004356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:ammonia ligase (ADP-forming)
GO:0004356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine synthetase activity
GO:0004356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamylhydroxamic synthetase activity
RHEA:43825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate
REACT:R-GGA-433576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+ (Gallus gallus)
REACT:R-HSA-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Homo sapiens)
REACT:R-BTA-174657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Bos taurus)
REACT:R-SSC-1474210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP14 (Sus scrofa)
RHEA:37230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-sorbate + H(+) <=> (E)-1,3-pentadiene + CO2
RHEA:21551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] <=> acetate + L-lysyl-[alpha-tubulin]
RHEA:58550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2
REACT:R-SSC-140806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINC1 binds SERPINC1 activators (Sus scrofa)
RHEA:53157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
RHEA:42902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(745) in 23S rRNA + S-adenosyl-L-methionine
REACT:R-CFA-1497853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Canis familiaris)
RHEA:16428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + NAD(+) <=> formate + 2 H(+) + NADH
RHEA:71788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + O2 => (R)-2-hydroxyglutarate + CO2
REACT:R-HSA-5684273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Homo sapiens)
REACT:R-CEL-2684507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2, 4, (3) bind FGF2 (Caenorhabditis elegans)
REACT:R-CFA-8951499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides on to class I MHC (Canis familiaris)
REACT:R-CEL-6784959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPHL hydrolyses VACV to ACV (Caenorhabditis elegans)
RHEA:36380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4alpha-methylzymosterol + H(+) + NADPH => 4alpha-methylzymosterol + NADP(+)
REACT:R-DME-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Drosophila melanogaster)
RHEA:19247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminophenol => N-phenylhydroxylamine
RHEA:11537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + H2O + 2 O2 => glycine betaine + H(+) + 2 H2O2
REACT:R-RNO-8950766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA dimerizes (Rattus norvegicus)
RHEA:64771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-3-(hexan-1-ol)-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol
REACT:R-SSC-5654730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Sus scrofa)
REACT:R-SPO-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Schizosaccharomyces pombe)
REACT:R-XTR-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Xenopus tropicalis)
REACT:R-MMU-5665761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL3 binds RHOC:GTP (Mus musculus)
REACT:R-DME-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Drosophila melanogaster)
REACT:R-MMU-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Mus musculus)
RHEA:72022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + O2 + trihazone A <=> 2 CO2 + H2O + succinate + trihazone D
RHEA:25223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + taurine => H(+) + L-cysteate
REACT:R-MMU-5621366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to p-Y65,Y76-FCER1G (Mus musculus)
REACT:R-MMU-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)
REACT:R-RNO-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Rattus norvegicus)
REACT:R-DME-1234167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of HIF:CBP:p300 complex at promoters (Drosophila melanogaster)
REACT:R-CFA-390593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Canis familiaris)
REACT:R-MMU-9012315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Mus musculus)
REACT:R-XTR-1254251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds YAP1 (Xenopus tropicalis)
REACT:R-RNO-8943987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCUBE1, SCUBE3 oligomerize (Rattus norvegicus)
REACT:R-DME-9708104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE5A dimer binds PDE5A inhibitors (Drosophila melanogaster)
REACT:R-CFA-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Canis familiaris)
RHEA:63465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + UTP => (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP
RHEA:17934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-hydroxyisoflavone + S-adenosyl-L-methionine => a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine
GO:0102973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norsolorinate anthrone synthase activity
GO:0102973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norsolorinic acid synthase
RHEA:61448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tigecycline = 11a-hydroxytigecycline + H2O + NADP(+)
RHEA:28714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) <=> H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)
REACT:R-RNO-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Rattus norvegicus)
REACT:R-MMU-114671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vWF binds to collagen (Mus musculus)
RHEA:37955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate
RHEA:28919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) + L-glutamate(out) = 4-aminobutanoate(out) + L-glutamate(in)
RHEA:36961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose + NAD(+) => D-ribono-1,4-lactone + H(+) + NADH
REACT:R-HSA-164056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of pChREBP (Ser 568) by PP2A (Homo sapiens)
RHEA:11596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"orotidine-5'-phosphate decarboxylase"
RHEA:11596	skos:altLabel	"orotidine-5'-phosphate carboxy-lyase"
RHEA:11596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + orotidine 5'-phosphate = CO2 + UMP
RHEA:11596	skos:altLabel	"orotidylic decarboxylase"
RHEA:11596	skos:prefLabel	"orotidine-5'-phosphate decarboxylase"
RHEA:11596	skos:altLabel	"OMPdcase"
RHEA:11596	skos:altLabel	"UMP synthase"
RHEA:11596	skos:altLabel	"OMP decarboxylase"
RHEA:11596	skos:altLabel	"uridine 5'-monophosphate synthase"
REACT:R-HSA-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Homo sapiens)
REACT:R-DRE-72185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA polyadenylation (Danio rerio)
RHEA:47159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,25-dihydroxycholesterol + NAD(+) <=> 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH
REACT:R-CFA-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Canis familiaris)
RHEA:48782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-erythrulose 1-phosphate => ATP + L-erythrulose
REACT:R-BTA-3782637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC8 deacetylates histones (Bos taurus)
REACT:R-MMU-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Mus musculus)
REACT:R-DME-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Drosophila melanogaster)
REACT:R-CFA-70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer oxidises LACT to PYR (Canis familiaris)
RHEA:11118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetylalkane-alpha,omega-diamine + CoA + H(+) => acetyl-CoA + an alkane-alpha,omega-diamine
REACT:R-DRE-9023627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)
GO:0004337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesyl pyrophosphate synthetase activity
GO:0004337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesylpyrophosphate synthetase activity
GO:0004337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl transferase I
GO:0004337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyltransferase activity
GO:0004337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity
GO:0004337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranyltranstransferase activity
GO:0004337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FPP synthetase activity
GO:0004337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesyl diphosphate synthetase activity
GO:0004337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesyl-diphosphate synthase activity
REACT:R-SCE-191983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)
RHEA:29600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5685902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Mus musculus)
REACT:R-DRE-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Danio rerio)
RHEA:60053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)
RHEA:61354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + riboflavin(out) => ATP + H2O + riboflavin(in)
REACT:R-HSA-8855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR binds DAB1 (Homo sapiens)
RHEA:26524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-trans-aconitate + H2O => (2S,3S)-2-methylcitrate
RHEA:49891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2
RHEA:49013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADH + O2 => aurachin C epoxide + H2O + NAD(+)
REACT:R-HSA-9714483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the ER membrane (Homo sapiens)
RHEA:50549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E1 => H2O + prostaglandin A1
RHEA:53886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + CDP + H(+) => CDP-alpha-D-glucose + D-glucose 6-phosphate
RHEA:60052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)
REACT:R-DME-6799202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Drosophila melanogaster)
REACT:R-RNO-9663511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds GSTA1, FABP1 (Rattus norvegicus)
REACT:R-SSC-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Sus scrofa)
REACT:R-RNO-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Rattus norvegicus)
RHEA:20341	skos:prefLabel	"sn-glycerol-3-phosphate 1-galactosyltransferase"
RHEA:20341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sn-glycerol-3-phosphate 1-galactosyltransferase"
RHEA:20341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP
RHEA:20341	skos:altLabel	"isofloridoside-phosphate synthase"
REACT:R-RNO-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)
REACT:R-XTR-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Xenopus tropicalis)
REACT:R-SSC-9706354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of FLT3 (Sus scrofa)
REACT:R-CEL-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Caenorhabditis elegans)
REACT:R-DRE-9755304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUL1 ubiquitinates UBXN7 (Danio rerio)
REACT:R-XTR-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Xenopus tropicalis)
REACT:R-GGA-2454113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 transports 11cRAL to rod photoreceptor outer segment (Gallus gallus)
REACT:R-SSC-70355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALK1 phosphorylates Gal to Gal1P (Sus scrofa)
REACT:R-HSA-5250209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP binds SLC25A4 (Homo sapiens)
REACT:R-XTR-442273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV1 is a GEF for Rho/Rac family GTPases (Xenopus tropicalis)
REACT:R-DRE-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Danio rerio)
RHEA:33481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + lanosteryl ester => an acyl-CoA + lanosterol
GO:0070678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	unprocessed protein binding
GO:0070678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	preprotein binding
REACT:R-DDI-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Dictyostelium discoideum)
REACT:R-XTR-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)
REACT:R-GGA-174439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Gallus gallus)
REACT:R-CEL-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
RHEA:34978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate(in) <=> (R)-pantothenate(out)
RHEA:32808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate(in) => thiosulfate(out)
REACT:R-BTA-2395992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,4S-IRF3 is dimerized (Bos taurus)
RHEA:19572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-3108209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
RHEA:53309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Caenorhabditis elegans)
RHEA:61876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-SSC-2046239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular KSPG translocates to the lysosome for degradation (Sus scrofa)
RHEA:29681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(out) => formate(in)
REACT:R-DRE-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)
REACT:R-HSA-9759709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNBP binds SARS-CoV-2 G-rich RNA (Homo sapiens)
REACT:R-MMU-2473594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP15 (Mus musculus)
REACT:R-DDI-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Dictyostelium discoideum)
RHEA:59540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2
REACT:R-MMU-6799097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates ZNF420 (Mus musculus)
REACT:R-BTA-2187325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 ADP-ribosylates SMAD3 and SMAD4 (Bos taurus)
RHEA:55883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aequorin]--coelenterazine + O2 <=> [aequorin]
REACT:R-DME-8944262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type X (Drosophila melanogaster)
REACT:R-CEL-158468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates PARA to PARA-SO4 (Caenorhabditis elegans)
REACT:R-RNO-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Rattus norvegicus)
RHEA:22778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 Mn(3+) => 2 H(+) + H2O2 + 2 Mn(2+)
RHEA:49541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate
REACT:R-DME-209218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DL/DIF dimer activates transcription (Drosophila melanogaster)
REACT:R-BTA-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Bos taurus)
RHEA:15809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = (R)-linalool + diphosphate
RHEA:15809	skos:prefLabel	"R-linalool synthase"
RHEA:15809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"R-linalool synthase"
RHEA:15809	skos:altLabel	"(-)-3R-linalool synthase"
RHEA:15809	skos:altLabel	"(3R)-linalool synthase"
REACT:R-MMU-8875443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates LRIG1 (Mus musculus)
REACT:R-XTR-8852552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1R autophosphorylates (Xenopus tropicalis)
REACT:R-RNO-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)
REACT:R-MMU-4332235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds TGFBR2 (Mus musculus)
RHEA:62216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoepoxydon + NADP(+) = H(+) + NADPH + phyllostine
REACT:R-XTR-5696131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC1 deaminates Hist (Xenopus tropicalis)
REACT:R-HSA-378952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin is a heterodimer (Homo sapiens)
RHEA:35170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	minocycline(in) <=> minocycline(out)
REACT:R-DRE-158722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Danio rerio)
REACT:R-DME-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Drosophila melanogaster)
REACT:R-HSA-5666046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRF:MKL1 binds ITGB1 Gene (Homo sapiens)
RHEA:19209	skos:prefLabel	"codeinone reductase (NADPH)"
RHEA:19209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"codeinone reductase (NADPH)"
RHEA:19209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	codeine + NADP(+) = codeinone + H(+) + NADPH
RHEA:28416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+) => gamma-L-glutamylputrescine + H2O + O2
REACT:R-DRE-5675947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF18 binds TNFRSF18 (Danio rerio)
RHEA:19503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + urea => 4-guanidinobutanoate + H2O
REACT:R-DRE-5654651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS3 (Danio rerio)
REACT:R-MMU-9749647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES2 hydrolyzes ASA- (Mus musculus)
REACT:R-BTA-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Bos taurus)
REACT:R-SSC-432129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds and phosphorylates LRP8 (Sus scrofa)
RHEA:12209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferyl acetate + H2O => 4-methylumbelliferone + acetate + H(+)
REACT:R-BTA-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)
RHEA:46219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + progesterone <=> 3beta-hydroxypregn-4-ene-20-one + NADP(+)
REACT:R-DDI-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Dictyostelium discoideum)
REACT:R-SSC-388560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA,EDNRB bind EDNs (Sus scrofa)
REACT:R-SSC-8950269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Sus scrofa)
RHEA:30020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + lipid A-core
REACT:R-MMU-77263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Mus musculus)
GO:0008790	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinose ketol-isomerase activity
GO:0008790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose = D-ribulose
GO:0008790	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinose(L-fucose) isomerase activity
GO:0008790	skos:prefLabel	"D-arabinose isomerase"
GO:0008790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinose isomerase activity
GO:0008790	skos:altLabel	"arabinose isomerase"
GO:0008790	skos:altLabel	"L-fucose isomerase"
GO:0008790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arabinose isomerase"
GO:0008790	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D-arabinose isomerase activity
GO:0008790	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinose aldose-ketose-isomerase activity
RHEA:48510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)
REACT:R-DDI-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Dictyostelium discoideum)
RHEA:63838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxyhexadecanoate => hexadecanoate + O2
REACT:R-XTR-8952625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Xenopus tropicalis)
REACT:R-BTA-8983078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Bos taurus)
REACT:R-HSA-4396393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)
REACT:R-BTA-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Bos taurus)
REACT:R-DME-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Drosophila melanogaster)
REACT:R-GGA-353023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoglycerate + ATP <=> 1,3-bisphosphoglycerate + ADP (Gallus gallus)
RHEA:45977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)
REACT:R-HSA-5362450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh processing variants bind lectins (Homo sapiens)
RHEA:58627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-dodecanoyl-(2S)-hydroxyglycine <=> dodecanamide + glyoxylate
REACT:R-SSC-174238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Sus scrofa)
RHEA:32006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene
RHEA:57324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]
REACT:R-CEL-1964501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Caenorhabditis elegans)
REACT:R-CFA-8851827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Canis familiaris)
REACT:R-MMU-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Mus musculus)
REACT:R-SPO-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Schizosaccharomyces pombe)
REACT:R-HSA-8948219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3 binds Lysyl hydroxylated collagen propeptides (Homo sapiens)
REACT:R-HSA-450580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 (hnRNP D0) is ubiquitinylated (Homo sapiens)
RHEA:10233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine 5'-monophosphate + diphosphate => 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate
RHEA:35962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tryprostatin B <=> demethoxyfumitremorgin C + 2 H2O + NADP(+)
REACT:R-SSC-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Sus scrofa)
REACT:R-DME-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Drosophila melanogaster)
REACT:R-XTR-9013022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GAPs stimulate RHOB GTPase activity (Xenopus tropicalis)
RHEA:47377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:42599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> prostaglandin G2
RHEA:15491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-riburonosyladenine + H(+) + 2 H2O2 => adenosine + H2O + 2 O2
RHEA:64980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-3858489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds DAAM1 (Mus musculus)
GO:0047094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)
GO:0047094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetate 6-hydroxylase activity
GO:0047094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyphenylacetate 6-monooxygenase activity
REACT:R-MMU-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Mus musculus)
REACT:R-RNO-5682709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI4 binds ADAM22,23,11 (Rattus norvegicus)
RHEA:41260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan => (E)-3-(indol-3-yl)acrylate + NH4(+)
REACT:R-GGA-2559439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD14:LPS binds CR3 (Gallus gallus)
GO:0047642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldose b-D-fructosyltransferase activity
GO:0047642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity
GO:0047642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldose beta-D-fructosyltransferase activity
GO:2001080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitosan binding
GO:0042163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-12 beta subunit binding
GO:0042163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-12p40 binding
GO:0042163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLMFp40 binding
GO:0042163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NKSFp40 binding
GO:0042163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-12B binding
REACT:R-DRE-9648268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A antagonists (Danio rerio)
REACT:R-CEL-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Caenorhabditis elegans)
REACT:R-CEL-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Caenorhabditis elegans)
GO:0004629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidase C
GO:0004629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase C activity
RHEA:27451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate => a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O
REACT:R-XTR-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Xenopus tropicalis)
REACT:R-DME-1247497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds neuregulins (Drosophila melanogaster)
RHEA:54343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
REACT:R-HSA-2038946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of FGFR4 mutants with enhanced kinase activity (Homo sapiens)
REACT:R-GGA-9645442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Gallus gallus)
RHEA:14378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-aspartate => glycine + glyoxylate
RHEA:67773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O => a 5'-end dephospho-ribonucleoside-RNA + phosphate
REACT:R-DME-70333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KHK dimer phosphorylates Fru to Fru 1-P (Drosophila melanogaster)
REACT:R-HSA-9674567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 (Homo sapiens)
REACT:R-DRE-68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Danio rerio)
RHEA:71573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminoethoxy-methyl-dUMP in DNA + CO2 => 5-O-(L-seryl)-dTMP in DNA + H(+)
RHEA:33316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:40145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + CoA + H(+) => (9Z,12Z)-octadecadienoyl-CoA + H2O
RHEA:14236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA
RHEA:43905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol => all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:23302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate
REACT:R-HSA-977371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates Factor H-boundC3b (Homo sapiens)
REACT:R-MMU-5625959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Mus musculus)
REACT:R-XTR-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-SSC-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Sus scrofa)
REACT:R-RNO-9014293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GDIs block activation of RAC2 (Rattus norvegicus)
RHEA:30447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine
RHEA:27397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-demethylrebeccamycin + H2O = beta-D-glucose + dichloroarcyriaflavin A
RHEA:27397	skos:prefLabel	"4'-demethylrebeccamycin synthase"
RHEA:27397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4'-demethylrebeccamycin synthase"
RHEA:27397	skos:altLabel	"arcyriaflavin A N-glycosyltransferase"
RHEA:30632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-DME-8850539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GNB5:RGS dimers from CCT/TRiC (Drosophila melanogaster)
REACT:R-SSC-4724284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Sus scrofa)
RHEA:23545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP
RHEA:13918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH
RHEA:68808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-alpha-D-glucopyranosyl-D-fructose + H2O = alpha-D-glucose + D-fructose
RHEA:28610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XTP = diphosphate + H(+) + XMP
RHEA:47553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate + H2O => deoxycholate + glycine
REACT:R-RNO-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Rattus norvegicus)
REACT:R-MMU-5653878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Mus musculus)
REACT:R-DME-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Drosophila melanogaster)
REACT:R-CFA-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Canis familiaris)
REACT:R-HSA-5621918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GCK does not phosphorylate Glc to form G6P (Homo sapiens)
REACT:R-RNO-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Rattus norvegicus)
GO:0047888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid peroxidase activity
GO:0047888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acid peroxidase activity
GO:0047888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexadecanoate:hydrogen-peroxide oxidoreductase activity
GO:0047888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long chain fatty acid peroxidase activity
GO:0043726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine phosphatase activity
GO:0043726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity
REACT:R-CEL-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Caenorhabditis elegans)
REACT:R-BTA-1592349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14 (MT1-MMP) binds TIMP2 (Bos taurus)
REACT:R-DRE-1250346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Danio rerio)
REACT:R-BTA-6784319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,TYK2 phosphorylate JAK1,TYK2 (Bos taurus)
REACT:R-SPO-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Schizosaccharomyces pombe)
RHEA:18156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 GTP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate
REACT:R-GGA-873924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IFNGR1 by JAK kinases (Gallus gallus)
REACT:R-SSC-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Sus scrofa)
RHEA:57956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + H(+) + NADH + O2 = dimethyl sulfone + H2O + NAD(+)
RHEA:31181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-CoA + H(+) + NADH => (3S)-3-hydroxydodecanoyl-CoA + NAD(+)
GO:0086058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential
REACT:R-CFA-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)
RHEA:45086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CEL-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Caenorhabditis elegans)
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic guanosine 3',5'-monophosphate phosphodiesterase activity
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic guanosine 3',5'-phosphate phosphodiesterase activity
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic GMP phosphodiesterase activity
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP-specific phosphodiesterase activity
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine cyclic 3',5'-phosphate phosphodiesterase activity
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5' cyclic-GMP phosphodiesterase activity
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3',5'-cyclic-GMP 5'-nucleotidohydrolase activity
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP phosphodiesterase activity
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic-GMP phosphodiesterase activity
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cGMP-PDE
GO:0047555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic 3',5'-GMP phosphodiesterase activity
REACT:R-CEL-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Caenorhabditis elegans)
GO:0005094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rho GDP-dissociation inhibitor activity
REACT:R-PFA-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Plasmodium falciparum)
REACT:R-RNO-9701485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds JAK3 (Rattus norvegicus)
REACT:R-CFA-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)
REACT:R-CFA-5213464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is phosphorylated (Canis familiaris)
RHEA:57244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP = dGTP + H(+) + lactate
REACT:R-CFA-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Canis familiaris)
RHEA:33826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH <=> NAD(+) + tetrahydro-4-hydroxyphenylpyruvate
RHEA:70274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
REACT:R-XTR-9733964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Xenopus tropicalis)
RHEA:69724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-AMP + CoA => (indol-3-yl)acetyl-CoA + AMP + H(+)
RHEA:47484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + NAD(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
RHEA:70534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP
REACT:R-HSA-6802924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF is phosphorylated downstream of oncogenic RAS  (Homo sapiens)
RHEA:42575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) <=> 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2
REACT:R-SSC-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Sus scrofa)
RHEA:15122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dithioerythritol + thiosulfate => cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite
REACT:R-BTA-8948228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Bos taurus)
REACT:R-HSA-110213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTHL1 glycosylase mediated recognition and binding of formamidopyrimidine (FapyA) (Homo sapiens)
REACT:R-HSA-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Homo sapiens)
RHEA:31368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 nitrite => H2O + nitrate + 2 nitric oxide
REACT:R-MMU-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
REACT:R-MMU-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Mus musculus)
REACT:R-HSA-9733403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds PCSK9 inhibitors (Homo sapiens)
RHEA:54195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
REACT:R-CEL-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Caenorhabditis elegans)
REACT:R-HSA-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
REACT:R-HSA-8848087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAP2 recruits STAT3 to PTK6 (Homo sapiens)
RHEA:42194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-SSC-201595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plakophilin-1 (Sus scrofa)
REACT:R-HSA-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Homo sapiens)
RHEA:18489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate + H(+) + hydrogencarbonate = carbamate + CO2
REACT:R-DRE-8950423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Danio rerio)
REACT:R-DDI-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Dictyostelium discoideum)
REACT:R-XTR-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Xenopus tropicalis)
RHEA:69460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine = [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine
RHEA:38875	skos:prefLabel	"23S rRNA pseudouridine(2604) synthase"
RHEA:38875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA pseudouridine(2604) synthase"
RHEA:38875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA
RHEA:36646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	emodin + S-adenosyl-L-methionine <=> H(+) + questin + S-adenosyl-L-homocysteine
REACT:R-SCE-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Saccharomyces cerevisiae)
RHEA:46456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-HSA-8868567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5:p25 phosphorylates PRDX1 (Homo sapiens)
GO:0008661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose-5-phosphate synthase activity
GO:0008661	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)
GO:0008661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity
GO:0008661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOXP synthase activity
GO:0008661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxyxylulose-5-phosphate synthase activity
GO:0008661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DXP-synthase activity
RHEA:44198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylundecanoyl-CoA + AMP + diphosphate => 3-methylundecanoate + ATP + CoA
REACT:R-BTA-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Bos taurus)
RHEA:43894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + L-alanine => [sulfur carrier]-H + L-cysteine
RHEA:64559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one <=> 8-epi-ilicicolin H
REACT:R-RNO-6807053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SC5D desaturates LTHSOL to 7-dehydroCHOL (Rattus norvegicus)
REACT:R-CEL-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Caenorhabditis elegans)
RHEA:44671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)
REACT:R-DDI-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Dictyostelium discoideum)
REACT:R-XTR-3858482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is recruited to the receptor (Xenopus tropicalis)
RHEA:70450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate
RHEA:43241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate
REACT:R-SSC-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Sus scrofa)
REACT:R-RNO-201443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II receptor phosphorylates type I receptor (Rattus norvegicus)
REACT:R-RNO-1237047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ hydrates CO2 to HCO3- (Rattus norvegicus)
REACT:R-HSA-8874193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L1 translocates from the cytosol to the nucleus (Homo sapiens)
RHEA:30723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 2 ADP + H(+) + NH4(+) + 2 phosphate = AH2 + 2 ATP + H2O + hydroxylamine
REACT:R-CFA-9027273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)
REACT:R-CFA-2509816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses IDP to IMP (Canis familiaris)
REACT:R-DRE-5610720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI3 (Danio rerio)
RHEA:52459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone + UDP-alpha-D-glucuronate <=> H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP
RHEA:12372	skos:altLabel	"dienelactone hydrolase"
RHEA:12372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O = 4-oxohex-2-enedioate + H(+)
RHEA:12372	skos:altLabel	"maleylacetate enol-lactonase"
RHEA:12372	skos:prefLabel	"carboxymethylenebutenolidase"
RHEA:12372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxymethylenebutenolidase"
RHEA:63833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-methylnon-6-enoyl-CoA + vanillylamine => capsaicin + CoA + H(+)
REACT:R-BTA-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Bos taurus)
REACT:R-GGA-5654672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR1 (Gallus gallus)
REACT:R-GGA-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Gallus gallus)
REACT:R-DDI-350901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is organified (Dictyostelium discoideum)
REACT:R-HSA-9012196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translation is negatively regulated by miR-26A and B (Homo sapiens)
GO:1990311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type-I cohesin domain binding
REACT:R-DRE-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Danio rerio)
REACT:R-SSC-170026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protons are translocated from the intermembrane space to the matrix (Sus scrofa)
RHEA:21513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-L-galactonate => 2-dehydro-3-deoxy-L-galactonate
RHEA:45788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol = 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA
RHEA:25919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-6-ol <=> 6-hydroxyquinolin-2(1H)-one + AH2
REACT:R-BTA-1655831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 translocates to the nucleus (Bos taurus)
REACT:R-HSA-9028255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises EPA to PGH3 (Homo sapiens)
REACT:R-XTR-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Xenopus tropicalis)
RHEA:38443	skos:prefLabel	"long-chain-alcohol O-fatty-acyltransferase"
RHEA:38443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-alcohol O-fatty-acyltransferase"
RHEA:38443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + a long chain fatty alcohol = a wax ester + CoA
RHEA:38443	skos:altLabel	"wax synthase"
RHEA:63128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-docosanoyl-ethanolamine = docosanoate + ethanolamine
GO:0050486	skos:prefLabel	"Transferring hydroxy groups"
GO:0050486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular transferase activity, transferring hydroxy groups
GO:0050486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring hydroxy groups"
REACT:R-GGA-8862184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP48 cleaves polyubiquitin (Gallus gallus)
REACT:R-HSA-170070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)
RHEA:45369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (9Z)-octadecenoate
REACT:R-DRE-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Danio rerio)
REACT:R-BTA-2730843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LAT by p-SYK (Bos taurus)
REACT:R-CFA-6804242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the complex of JMY, EP300 and TTC5 (Canis familiaris)
GO:0004631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphomevalonate kinase activity
GO:0004631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphomevalonate kinase"
GO:0004631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonic acid phosphate kinase activity
GO:0004631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonate-5-phosphate kinase activity
GO:0004631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonate phosphate kinase activity
GO:0004631	skos:prefLabel	"phosphomevalonate kinase"
GO:0004631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:(R)-5-phosphomevalonate phosphotransferase activity
GO:0004631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:5-phosphomevalonate phosphotransferase activity
GO:0004631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP
GO:0004631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphomevalonate kinase activity
REACT:R-DDI-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Dictyostelium discoideum)
REACT:R-MMU-844438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 oligomerizes (Mus musculus)
REACT:R-HSA-1606682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)
REACT:R-SSC-9038052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GREB1 binds ESR1:ESTG and co-activators (Sus scrofa)
RHEA:53424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + a sphingoid base = an N-acyl-sphingoid base + CoA + H(+)
RHEA:21473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + CoA => (3S)-citryl-CoA + ADP + phosphate
RHEA:39041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate + 2 H(+) + NADH => an omega-oxo fatty acid + H2O + NAD(+)
REACT:R-SSC-389424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The orphan QRFP receptor can bind neuropeptide QRFP (Sus scrofa)
REACT:R-HSA-9667914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand midkine (MDK) (Homo sapiens)
RHEA:43972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)
RHEA:58796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 7-O-beta-D-glucoside + malonyl-CoA = a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA
REACT:R-HSA-8853309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3 fusions (Homo sapiens)
REACT:R-HSA-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Homo sapiens)
RHEA:32222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene <=> gamma-carotene
RHEA:18132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoaldehyde + H2O + NADP(+) <=> a 2-oxocarboxylate + 2 H(+) + NADPH
RHEA:59349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltobiono-1,5-lactone + H2O => D-maltobionate + H(+)
REACT:R-SSC-975594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLB1 hydrolyses RPALM to atROL (Sus scrofa)
GO:0030558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA pseudouridylation guide activity
REACT:R-GGA-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Gallus gallus)
REACT:R-SSC-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Sus scrofa)
REACT:R-DRE-2428922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Danio rerio)
RHEA:38046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-9626928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP binds FOXO1 (Canis familiaris)
REACT:R-HSA-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Homo sapiens)
REACT:R-MMU-8850786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK12 (Mus musculus)
RHEA:40250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + rhodomycin D <=> 10-carboxy-13-deoxycarminomycin + H(+) + methanol
REACT:R-DRE-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Danio rerio)
RHEA:14868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + tyramine <=> H(+) + N-methyltyramine + S-adenosyl-L-homocysteine
RHEA:50312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + H(+) = butanal + CO2
RHEA:23296	skos:prefLabel	"N-acetylneuraminate lyase"
RHEA:23296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aceneuramate = N-acetyl-D-mannosamine + pyruvate
RHEA:23296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylneuraminate lyase"
RHEA:23296	skos:altLabel	"N-acetylneuraminic acid aldolase"
RHEA:23296	skos:altLabel	"N-acetylneuraminate pyruvate-lyase"
REACT:R-CEL-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Caenorhabditis elegans)
RHEA:31214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-selenomethionine <=> diphosphate + L-adenosylselenomethionine + phosphate
REACT:R-HSA-6801675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates NPM1 (Homo sapiens)
REACT:R-CEL-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Caenorhabditis elegans)
REACT:R-BTA-9728723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Bos taurus)
REACT:R-XTR-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Xenopus tropicalis)
REACT:R-SCE-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Saccharomyces cerevisiae)
REACT:R-BTA-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Bos taurus)
REACT:R-DRE-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Danio rerio)
REACT:R-BTA-9007882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 is cleaved (Bos taurus)
REACT:R-XTR-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)
REACT:R-CEL-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Caenorhabditis elegans)
GO:0061652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAT10 conjugating enzyme activity
GO:0061652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
REACT:R-DME-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)
REACT:R-SCE-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Saccharomyces cerevisiae)
RHEA:64056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-ephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
RHEA:20406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + acetate
REACT:R-HSA-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Homo sapiens)
RHEA:72091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + Na(+)(out) = (R)-carnitine(in) + Na(+)(in)
REACT:R-GGA-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Gallus gallus)
REACT:R-BTA-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Bos taurus)
REACT:R-MMU-2161293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin forms aggregate globules (Mus musculus)
RHEA:18486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-acetyl-D-glucose + H2O => acetate + D-glucose + H(+)
RHEA:35982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + verruculogen <=> diphosphate + fumitremorgin A
RHEA:46582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2
REACT:R-DDI-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Dictyostelium discoideum)
REACT:R-CFA-202443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of CARMA1 (Canis familiaris)
REACT:R-CFA-4332363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation and activation of CAMK2 (Canis familiaris)
RHEA:52632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP
RHEA:55645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] => ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate
RHEA:24374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine => H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein]
RHEA:60517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan => D-tryptophan
REACT:R-DME-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Drosophila melanogaster)
REACT:R-HSA-8871366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Homo sapiens)
GO:0030353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR antagonist activity
GO:0030353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGF receptor antagonist activity
GO:0030353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibroblast growth factor receptor antagonist activity
REACT:R-SSC-2172666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds condensin II (Sus scrofa)
RHEA:56086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-L-serine + H(+) + phosphocholine => [Rab1 protein]-O-phosphocholine-L-serine + H2O
RHEA:45565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone => 5-epi-valiolone
GO:0016987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial sigma factor activity
GO:0016987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-dependent RNA polymerase promoter selection factor
GO:0016987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	promoter selection factor activity
GO:0016987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sigma transcription factor
GO:0016987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	core DNA-dependent RNA polymerase binding promoter specificity activity
GO:0016987	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plastid sigma factor activity
GO:0016987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sigma factor activity
REACT:R-CEL-1433514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)
RHEA:68846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-alpha-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate
REACT:R-XTR-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Xenopus tropicalis)
RHEA:30088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2
REACT:R-MMU-1638845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERK phosphorylates CERA to form C1P (Mus musculus)
RHEA:44981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + butanoyl-CoA => CoA + O-butanoyl-(R)-carnitine
REACT:R-XTR-176609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + PAPS => cholesterol sulfate + PAP (Xenopus tropicalis)
REACT:R-SCE-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Saccharomyces cerevisiae)
REACT:R-RNO-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Rattus norvegicus)
REACT:R-DME-8963864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN dissociates from 25(OH)D (Drosophila melanogaster)
REACT:R-DRE-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Danio rerio)
REACT:R-DDI-1855208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Dictyostelium discoideum)
REACT:R-RNO-9013024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors at the plasma membrane (Rattus norvegicus)
REACT:R-HSA-5686286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Homo sapiens)
REACT:R-HSA-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Homo sapiens)
REACT:R-MMU-2105001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from DS (Mus musculus)
REACT:R-BTA-202291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Lck (Bos taurus)
RHEA:71219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + nitrate(out) = 2 Na(+)(in) + nitrate(in)
RHEA:36400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3beta-ol + NADP(+) => H(+) + NADPH + zymosterol
RHEA:66732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate
RHEA:66440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-one + NADP(+) = but-3-en-2-one + H(+) + NADPH
REACT:R-DRE-9757686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDL (Danio rerio)
RHEA:55627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O <=> 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)
REACT:R-HSA-163664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binds to gamma subunit of AMP kinase heterotrimer (Homo sapiens)
REACT:R-SSC-164423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PhosphoChREBP (Thr 666)  is exported to cytosol (Sus scrofa)
RHEA:20999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-aminomuconate + H2O <=> (3E)-2-oxohex-3-enedioate + NH4(+)
REACT:R-GGA-9033520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves TYSND1 (Gallus gallus)
GO:0050224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prunasin hydrolase activity
GO:0050224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunasin beta-glucosidase activity
GO:0050224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prunasin beta-D-glucohydrolase activity
GO:0050224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunasin b-glucosidase activity
REACT:R-DRE-8956568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the core TAL1 complex (Danio rerio)
RHEA:69159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermine dialdehyde <=> acrolein + N-(4-aminobutyl)-3-aminopropanal
RHEA:36467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanylglycine = glycine + L-alanine
RHEA:12902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arginine + H2O => D-ornithine + urea
RHEA:12953	skos:altLabel	"GPBPK"
RHEA:12953	skos:prefLabel	"[Goodpasture-antigen-binding protein] kinase"
RHEA:12953	skos:altLabel	"GPBP kinase"
RHEA:12953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]
RHEA:12953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]
RHEA:12953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[Goodpasture-antigen-binding protein] kinase"
RHEA:12953	skos:altLabel	"Goodpasture antigen-binding protein kinase"
REACT:R-HSA-420233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VIP receptors bind VIP (Homo sapiens)
REACT:R-GGA-353283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks (Gallus gallus)
RHEA:16548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA + oxalate <=> formate + oxalyl-CoA
RHEA:46919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juvenile hormone I <=> H(+) + juvenile hormone I carboxylate + methanol
EC:2.4.1.205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactogen 6beta-galactosyltransferase"
EC:2.4.1.205	skos:altLabel	"1,6-D-galactosyltransferase"
EC:2.4.1.205	skos:prefLabel	"galactogen 6beta-galactosyltransferase"
RHEA:40455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA = (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA
RHEA:44859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-octadecenoyl-(R)-carnitine
RHEA:67301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one => 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one
REACT:R-XTR-6807064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces ZYMOL to ZYMSTNL (Xenopus tropicalis)
REACT:R-XTR-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Xenopus tropicalis)
RHEA:57608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-chlorocatechol + H(+) + NADH
RHEA:57608	skos:prefLabel	"chlorobenzene dihydrodiol dehydrogenase"
RHEA:57608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorobenzene dihydrodiol dehydrogenase"
REACT:R-HSA-180627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Vpr with importin alpha (Homo sapiens)
REACT:R-RNO-2028692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK4 (p-MST1) by caspase 3 (Rattus norvegicus)
REACT:R-RNO-5666216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds TAX1BP3 (Rattus norvegicus)
REACT:R-HSA-192137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
REACT:R-SPO-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Schizosaccharomyces pombe)
REACT:R-XTR-8982637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins binds G alpha-t (Xenopus tropicalis)
GO:0042379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine receptor binding
GO:0042379	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	chemokine receptor ligand
REACT:R-CFA-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Canis familiaris)
REACT:R-RNO-9691421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK binds BTK inhibitors (Rattus norvegicus)
RHEA:30748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + hexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + FADH2
REACT:R-SSC-165179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TSC1:TSC2 complex (Sus scrofa)
REACT:R-HSA-2263495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S (Homo sapiens)
REACT:R-RNO-8852481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Rattus norvegicus)
RHEA:54636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-yl diphosphate = diphosphate + labda-7,13(16),14-triene
RHEA:54636	skos:prefLabel	"labda-7,13(16),14-triene synthase"
RHEA:54636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"labda-7,13(16),14-triene synthase"
RHEA:11893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-methylnorlaudanosoline + S-adenosyl-L-methionine => H(+) + nororientaline + S-adenosyl-L-homocysteine
REACT:R-HSA-399712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Homo sapiens)
REACT:R-SSC-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Sus scrofa)
REACT:R-XTR-5653886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1 binds LALBA (Xenopus tropicalis)
REACT:R-DME-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Drosophila melanogaster)
RHEA:64990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => CoA + H2O
REACT:R-CEL-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
RHEA:51849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-methylmenaquinone-6 + succinate => 8-methylmenaquinol-6 + fumarate
REACT:R-SSC-158942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)
REACT:R-SSC-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Sus scrofa)
REACT:R-SSC-389532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A binds CTLA4 dimer (Sus scrofa)
RHEA:34886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + selenate(out) <=> ADP + H(+) + phosphate + selenate(in)
REACT:R-SPO-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Schizosaccharomyces pombe)
REACT:R-HSA-210974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS-1 to Tie2 bound  Grb2 (Homo sapiens)
RHEA:41655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin S + dTDP-2-deoxy-beta-L-fucose <=> 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)
REACT:R-SSC-420591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-2:Nectin 3 trans heterodimer interaction (Sus scrofa)
REACT:R-BTA-9714959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to TNF(1-233) trimer (Bos taurus)
RHEA:16909	skos:prefLabel	"glycine dehydrogenase (cytochrome)"
RHEA:16909	skos:altLabel	"glycine-cytochrome c reductase"
RHEA:16909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + glycine + H2O = 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)
RHEA:16909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine dehydrogenase (cytochrome)"
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline-phosphate cytidylyltransferase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline phosphate cytidylyltransferase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylcholine transferase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-choline synthetase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-choline pyrophosphorylase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphocholine pyrophosphorylase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:phosphocholine cytidylyltransferase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:phosphorylcholine cytidylyltransferase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylcholine:CTP cytidylyltransferase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP-phosphocholine cytidylyltransferase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphorylcholine cytidylyltransferase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphocholine cytidylyltransferase activity
GO:0004105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:choline-phosphate cytidylyltransferase activity
REACT:R-DDI-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Dictyostelium discoideum)
RHEA:50061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycochenodeoxycholate(in) + H2O => ADP + glycochenodeoxycholate(out) + H(+) + phosphate
RHEA:47419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an NDP-alpha-D-glucose + D-glucose <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)
REACT:R-SPO-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Schizosaccharomyces pombe)
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium-dependent malate transporter
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/malate symporter activity
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate:Na+ symporter activity
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	malate/sodium cotransporter activity
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:malate symporter activity
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate-sodium symporter activity
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	malate:sodium cotransporter activity
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate:sodium symporter activity
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate Na(+) symporter activity
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)-malate symporter activity
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate/sodium symporter activity
GO:0043882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+:malate symporter activity
REACT:R-CFA-2247511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2:ligand is endocytosed (Canis familiaris)
REACT:R-MMU-983696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Immunoglobulin of the BCR binds antigen (Mus musculus)
REACT:R-MMU-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Mus musculus)
REACT:R-HSA-6798082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind the CASP1 gene (Homo sapiens)
REACT:R-MMU-199298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CREB1 (Mus musculus)
RHEA:23320	skos:prefLabel	"D-tryptophan N-malonyltransferase"
RHEA:23320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-tryptophan N-malonyltransferase"
RHEA:23320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophan + malonyl-CoA = CoA + H(+) + N(2)-malonyl-D-tryptophan
RHEA:48792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + Lc4Cer = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
RHEA:50470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH
REACT:R-MMU-6797956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC44A1 transports Cho from cytosol to mitochondrial matrix (Mus musculus)
REACT:R-DRE-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Danio rerio)
REACT:R-SCE-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Saccharomyces cerevisiae)
REACT:R-BTA-417908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY1 binds ADP (Bos taurus)
GO:0062182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0062182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans retinoic acid 4-hydrolase activity
REACT:R-CEL-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Caenorhabditis elegans)
REACT:R-SPO-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Schizosaccharomyces pombe)
REACT:R-XTR-2395322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyridinoline cross-links (Xenopus tropicalis)
RHEA:49206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-SSC-6785762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL13RA1 binds TYK2 (Sus scrofa)
REACT:R-SSC-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Sus scrofa)
REACT:R-GGA-389487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 2 receptor can bind orexin-B neuropeptide (Gallus gallus)
RHEA:17485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
GO:0004045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyl-tRNA hydrolase activity
GO:0004045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacyl-tRNA hydrolase activity
GO:0004045	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D-tyrosyl-tRNA hydrolase activity
GO:0004045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoacyl-tRNA aminoacylhydrolase activity
GO:0004045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacyl-tRNA hydrolase reaction
GO:0004045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-substituted aminoacyl transfer RNA hydrolase activity
GO:0004045	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoacyl-transfer ribonucleate hydrolase activity
REACT:R-DME-110485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTSC1 AND DTSC2 form a complex (Drosophila melanogaster)
REACT:R-DRE-9011981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 is recruited to MYC and BCL2 genes (Danio rerio)
RHEA:68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esculetin + S-adenosyl-L-methionine <=> H(+) + isoscopoletin + S-adenosyl-L-homocysteine
RHEA:49999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:48199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA
REACT:R-HSA-8865994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds PTPN11 (Homo sapiens)
RHEA:56157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:55452	skos:prefLabel	"beta-amyrin 6beta-monooxygenase"
RHEA:55452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55452	skos:altLabel	"CYP716E26"
RHEA:55452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-amyrin 6beta-monooxygenase"
RHEA:18248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + ATP <=> ADP + CoA + H(+)
RHEA:42160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O
REACT:R-BTA-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Bos taurus)
REACT:R-CEL-5668947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates myosin phosphatase (Caenorhabditis elegans)
RHEA:40188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H2O => (3R)-hydroxyoctanoyl-CoA
REACT:R-DRE-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Danio rerio)
RHEA:12586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16,17-didehydroprogesterone + H2O => 16alpha-hydroxyprogesterone
RHEA:16888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 bilirubin-glucuronoside <=> bilirubin IXalpha + bilirubin-bisglucuronoside
REACT:R-CFA-177275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates DARPP-32 on Thr34 (Canis familiaris)
RHEA:54988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 e(-) + 4 H(+)(in) + O2(in) = 2 H2O(in)
REACT:R-DME-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Drosophila melanogaster)
REACT:R-MMU-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Mus musculus)
RHEA:52832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxylimonen-2-one + H(+) + NADPH + O2 = 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
RHEA:64155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)
REACT:R-RNO-6803789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Rattus norvegicus)
REACT:R-CFA-113429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongating transcript encounters a lesion in the template (Canis familiaris)
RHEA:38917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-DME-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Drosophila melanogaster)
REACT:R-CEL-8866551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR binds components of the ERAD machinery for ubiquitination and degradation (Caenorhabditis elegans)
EC:1.14.13.196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-ornithine N(5)-monooxygenase [NAD(P)H]"
EC:1.14.13.196	skos:prefLabel	"L-ornithine N(5)-monooxygenase [NAD(P)H]"
REACT:R-XTR-914012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Xenopus tropicalis)
RHEA:41313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-HSA-3323184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)
REACT:R-RNO-73806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIR + CO2 => CAIR (Rattus norvegicus)
REACT:R-BTA-6789092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide anion from oxygen (Bos taurus)
REACT:R-XTR-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Xenopus tropicalis)
REACT:R-DDI-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Dictyostelium discoideum)
REACT:R-SSC-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Sus scrofa)
REACT:R-CFA-2534378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hv1 Mediated H+ Permeability (Canis familiaris)
REACT:R-MMU-5623519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP and RAB8A bind to the ciliary targeting complex (Mus musculus)
REACT:R-MMU-8850777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK14 (Mus musculus)
RHEA:53152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
RHEA:44102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + octanoate => H2O + NAD(+) + octanal
GO:0036190	skos:altLabel	"CYP71C4"
GO:0036190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]
GO:0036190	skos:prefLabel	"indole-2-monooxygenase"
GO:0036190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-2-monooxygenase"
GO:0036190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-2-monooxygenase activity
REACT:R-HSA-9669911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of juxtamembrane domain KIT mutants (Homo sapiens)
REACT:R-HSA-9026916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT hydrolyses RCTR2 to RCTR3 (Homo sapiens)
REACT:R-DDI-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)
GO:0061599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdopterin molybdotransferase activity
GO:0061599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Homo sapiens)
REACT:R-DDI-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Dictyostelium discoideum)
REACT:R-GGA-8944214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type I (Gallus gallus)
RHEA:39245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+) => (11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH
RHEA:59302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly D-luciferin
REACT:R-GGA-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Gallus gallus)
EC:1.17.99.8	skos:prefLabel	"limonene dehydrogenase"
EC:1.17.99.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limonene dehydrogenase"
GO:0050559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copalyl diphosphate synthase activity
GO:0050559	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	diterpene cyclase activity
GO:0050559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-copalyl-diphosphate lyase (decyclizing)
REACT:R-GGA-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Gallus gallus)
REACT:R-HSA-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Homo sapiens)
REACT:R-RNO-5672948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK3 phosphorylates KSR1 (Rattus norvegicus)
REACT:R-SSC-9688831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK3 at K55, K363 (Sus scrofa)
RHEA:60949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + S-adenosyl-L-methionine => (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine
RHEA:30443	skos:prefLabel	"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase"
RHEA:30443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)
RHEA:30443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase"
RHEA:62584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-tyrosine(out) = ADP + H(+) + L-tyrosine(in) + phosphate
RHEA:62584	skos:prefLabel	"ABC-type tyrosine transporter"
RHEA:62584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type tyrosine transporter"
RHEA:45734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tyrosine
RHEA:34500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] => H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate
RHEA:70751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
RHEA:11917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) => 15-oxoprostaglandin E2 + H(+) + NADH
RHEA:17575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + macrocin + S-adenosyl-L-homocysteine => demethylmacrocin + S-adenosyl-L-methionine
REACT:R-XTR-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Xenopus tropicalis)
RHEA:42637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-cysteine + Mo-molybdopterin => A + H2O + L-alanine + thio-Mo-molybdopterin
REACT:R-XTR-209772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to triiodothyronine (Xenopus tropicalis)
REACT:R-DME-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Drosophila melanogaster)
REACT:R-MMU-71541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Mus musculus)
REACT:R-XTR-5626988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds NSMAF (Xenopus tropicalis)
REACT:R-HSA-114392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Homo sapiens)
RHEA:39957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + glycerol + H(+) => (9Z-octadecenoyl)-glycerol + H2O
REACT:R-DDI-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Dictyostelium discoideum)
REACT:R-BTA-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Bos taurus)
REACT:R-HSA-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Homo sapiens)
REACT:R-BTA-8852010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL2 binds activated T cells surface (Bos taurus)
REACT:R-CEL-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Caenorhabditis elegans)
GO:0015318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic solute uptake transmembrane transporter activity
GO:0015318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic molecular entity transmembrane transporter activity
GO:0015318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic uptake permease activity
RHEA:38334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol
REACT:R-SSC-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)
REACT:R-DME-4167509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial BTD hydrolyses BCTN (Drosophila melanogaster)
REACT:R-GGA-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Gallus gallus)
RHEA:28232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0004190	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carboxyl protease activity
GO:0004190	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartate protease activity
GO:0004190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic endopeptidase activity
GO:0004190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic-type endopeptidase activity
GO:0004190	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartic protease activity
GO:0004190	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartyl protease activity
REACT:R-DME-8877153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 binds PC (Drosophila melanogaster)
RHEA:12427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate
REACT:R-GGA-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Gallus gallus)
REACT:R-HSA-5654655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)
RHEA:18932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + thiophene-2-carbonyl-CoA <=> 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O
REACT:R-XTR-193070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPREG to DHA (Xenopus tropicalis)
REACT:R-GGA-8933446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Gallus gallus)
REACT:R-XTR-1295604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-RAF dissociates from S111/S120 p-SPRY2 (Xenopus tropicalis)
REACT:R-CFA-9627104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP3 (Canis familiaris)
REACT:R-RNO-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Rattus norvegicus)
RHEA:62036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)
RHEA:37522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-CEL-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Caenorhabditis elegans)
REACT:R-HSA-909552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 at Ser727 (Homo sapiens)
REACT:R-HSA-77283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Homo sapiens)
REACT:R-HSA-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
REACT:R-CFA-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Canis familiaris)
GO:0102795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthaldehyde:oxygen oxidoreductase activity
REACT:R-HSA-4546387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)
REACT:R-BTA-2028679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Bos taurus)
REACT:R-SSC-141156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL-mediated dimerization of procaspase-8 (Sus scrofa)
RHEA:56127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-lycopene + dimethylallyl diphosphate + H2O <=> AH2 + diphosphate + nonaflavuxanthin
REACT:R-XTR-9013024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors at the plasma membrane (Xenopus tropicalis)
REACT:R-GGA-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Gallus gallus)
REACT:R-SSC-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Sus scrofa)
REACT:R-SSC-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Sus scrofa)
REACT:R-DRE-209960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diiodinated tyrosine can be deiodinated (Danio rerio)
REACT:R-CFA-377186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Canis familiaris)
REACT:R-MMU-9603419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds SRC (Mus musculus)
REACT:R-SCE-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Saccharomyces cerevisiae)
REACT:R-DRE-444661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR2 binds HCAR2 ligands (Danio rerio)
REACT:R-SSC-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Sus scrofa)
REACT:R-RNO-5618098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Rattus norvegicus)
REACT:R-SSC-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Sus scrofa)
RHEA:67662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-RNO-421426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ProGIP translocates from the ER Lumen to secretory granules (Rattus norvegicus)
REACT:R-DME-3928617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB2 binds KALRN (Drosophila melanogaster)
REACT:R-SPO-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Schizosaccharomyces pombe)
REACT:R-HSA-901074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)
REACT:R-SSC-5687673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN recruits LIG3:XRCC1 to MMEJ sites (Sus scrofa)
REACT:R-SSC-1169399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Sus scrofa)
REACT:R-MMU-5666070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Mus musculus)
RHEA:32937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => a cardiolipin + H2O
REACT:R-XTR-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Xenopus tropicalis)
RHEA:48775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a <=> 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O
REACT:R-SSC-6806610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filament formation (Sus scrofa)
REACT:R-DME-975147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Drosophila melanogaster)
REACT:R-MMU-193694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 is recruited and forms a complex with TRAF6 (Mus musculus)
REACT:R-HSA-9612493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR-dependent NAB2 gene expression (Homo sapiens)
REACT:R-CFA-5229194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Depolymerization of lamin filaments after PKC-mediated phosphorylation (Canis familiaris)
REACT:R-PFA-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)
RHEA:16027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA
RHEA:68769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine
REACT:R-MMU-2130151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of DAP12 (Mus musculus)
REACT:R-HSA-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Homo sapiens)
RHEA:66223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-omegaC7-CoA + O2 <=> asc-omegaDeltaC7-CoA + H2O2
RHEA:35565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + ethanolamine => H2O + N-(9Z-hexadecenoyl) ethanolamine
RHEA:28439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]
RHEA:40044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + L-glutamate => ADP + beta-citrylglutamate + H(+) + phosphate
REACT:R-DME-482770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet secretory granule components (Drosophila melanogaster)
RHEA:67007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate
RHEA:36861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA
RHEA:51377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-dopamine
REACT:R-GGA-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)
RHEA:26448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + NADPH => 3-oxopropanoate + CoA + NADP(+)
REACT:R-CFA-8865265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds MYC and KDM5B (Canis familiaris)
RHEA:44966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + NADP(+) => (2E)-dodecenoyl-CoA + H(+) + NADPH
RHEA:39689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z)-octadecadienoyl-CoA + H2O => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA
REACT:R-RNO-5654597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)
REACT:R-CFA-170861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimeric TGF-beta-1 binds to the receptor (Canis familiaris)
RHEA:51673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + H2O => glycolate + H(+)
RHEA:13742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-tryptophan => indole-3-pyruvate + L-phenylalanine
RHEA:70737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + glycine betaine(in) + 2 Na(+)(in) => chloride(out) + glycine betaine(out) + 2 Na(+)(out)
RHEA:30344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + succinate => FADH2 + fumarate
RHEA:65125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + ethanol => benzyl acetate + CoA
REACT:R-MMU-1222685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathelicidin LL-37 binds to bacterial cell wall (Mus musculus)
RHEA:46347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanoyl-CoA + tetradecanoyl-CoA <=> 3-oxo-2-methylhexadecanoyl-CoA + CoA
GO:0051536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulfur cluster binding
GO:0051536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron sulfur cluster binding
GO:0051536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-sulphur cluster binding
GO:0051536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe/S binding
GO:0051536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron sulphur cluster binding
REACT:R-CEL-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Caenorhabditis elegans)
RHEA:12390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Danio rerio)
RHEA:24331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydrofolate + ATP + formate <=> 10-formyldihydrofolate + ADP + phosphate
GO:0090563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-sugar phosphotransferase activity
RHEA:31669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose
RHEA:69475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose <=> a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]
REACT:R-HSA-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Homo sapiens)
RHEA:32302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate + H(+) + NADH <=> 2 diphosphate + NAD(+) + squalene
RHEA:22646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + protopine + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-2559439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD14:LPS binds CR3 (Xenopus tropicalis)
REACT:R-SCE-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Saccharomyces cerevisiae)
RHEA:24862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose => H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP
REACT:R-DRE-189208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Danio rerio)
RHEA:37413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklaviketone + 2 H(+) + NADPH => aklavinone + NADP(+)
RHEA:58572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-15alpha-stemmadenine + O2 = H2O2 + precondylocarpine acetate
REACT:R-GGA-917835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from holoTF:TFRC dimer (Gallus gallus)
RHEA:12371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + A <=> 2,5-didehydro-D-gluconate + AH2
REACT:R-RNO-1483002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to 1-acyl GO3P by GNPAT (Rattus norvegicus)
REACT:R-DRE-975119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Danio rerio)
RHEA:69782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxindole-3-acetate + succinyl-CoA <=> (2-oxoindol-3-yl)acetyl-CoA + succinate
GO:0016993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	precorrin isomerase activity
GO:0016993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HBA synthase activity
GO:0016993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-8X methylmutase activity
GO:0016993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-8X 11,12-methylmutase activity
GO:0016993	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydrogenobyrinic acid-binding protein activity
GO:1990002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH
GO:1990002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylglyoxal reductase (NADPH-dependent, acetol producing)
REACT:R-GGA-4420099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHB  (Gallus gallus)
REACT:R-BTA-8848930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 translocates to the nucleus (Bos taurus)
GO:0015110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate transmembrane transporter activity
REACT:R-BTA-400092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Bos taurus)
EC:2.4.1.327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aclacinomycin-T 2-deoxy-L-fucose transferase"
EC:2.4.1.327	skos:prefLabel	"aclacinomycin-T 2-deoxy-L-fucose transferase"
GO:1990465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde oxygenase (deformylating) activity
RHEA:58676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + rifamycin SV = H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide
RHEA:58341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O => chenodeoxycholate + D-glucose
REACT:R-RNO-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Rattus norvegicus)
GO:0051779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0051779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GA12-aldehyde oxidase activity
GO:0051779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin 12-aldehyde oxidase activity
RHEA:43595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral
RHEA:45194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-MMU-8852298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Mus musculus)
REACT:R-HSA-8938389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds the LGALS3 gene promoter (Homo sapiens)
REACT:R-DME-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Drosophila melanogaster)
RHEA:65362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O
RHEA:66937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + 5-hydroxyanthranilate => avenanthramide C + CoA
REACT:R-DRE-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Danio rerio)
RHEA:57912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) = H(+) + L-glutaminyl-tRNA(Gln) + phosphate
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sedoheptulose 1,7-diphosphate phosphatase activity
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sedoheptulose-1,7-bisphosphatase activity
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose-bisphosphatase activity
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sedoheptulose 1,7-diphosphatase activity
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sedoheptulose diphosphatase activity
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SBPase activity
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 1,7-bisphosphate + H2O = D-sedoheptulose 7-phosphate + phosphate
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sedoheptulose-bisphosphatase"
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sedoheptulose bisphosphatase activity
GO:0050278	skos:altLabel	"Sedoheptulose-1,7-bisphosphatase"
GO:0050278	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sedoheptulose 1,7-bisphosphatase activity
GO:0050278	skos:prefLabel	"sedoheptulose-bisphosphatase"
RHEA:59049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ornithine + H(+) => CO2 + putrescine
REACT:R-HSA-8952039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
REACT:R-XTR-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Xenopus tropicalis)
REACT:R-HSA-212710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR activates PLC-gamma1 by phosphorylation (Homo sapiens)
RHEA:54593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate
REACT:R-DME-2162227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses (HA)2 (Drosophila melanogaster)
REACT:R-SSC-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Sus scrofa)
REACT:R-MMU-193816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Mus musculus)
REACT:R-XTR-448673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of caspase-1 p10/p20 dimer (Xenopus tropicalis)
REACT:R-MMU-9668831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CST complex formation (Mus musculus)
GO:0102979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homofuraneol oxidoreductase activity
REACT:R-DME-201640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Drosophila melanogaster)
RHEA:35194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	noranthrone + O2 <=> H2O + norsolorinic acid
REACT:R-PFA-8848339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA5 hydrolyzes TAG (Plasmodium falciparum)
REACT:R-HSA-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Homo sapiens)
RHEA:21992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]
REACT:R-CFA-450550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCalpha phosphorylates HuR (Canis familiaris)
REACT:R-HSA-5617650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXD3 chromatin is activated (Homo sapiens)
REACT:R-GGA-1564169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VIII degradation by MMP1 (Gallus gallus)
RHEA:59437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate
REACT:R-CFA-201603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of PKC theta (Canis familiaris)
REACT:R-SSC-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Sus scrofa)
REACT:R-HSA-1801587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CPT1A (Homo sapiens)
GO:0080176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xyloglucan 1,6-alpha-xylosidase activity
REACT:R-DRE-9714959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to TNF(1-233) trimer (Danio rerio)
REACT:R-SSC-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Sus scrofa)
REACT:R-HSA-9761858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent TALDO1 gene expression (Homo sapiens)
GO:0030743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity
GO:0030743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rRNA adenosine 2'-methylase activity
GO:0030743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA-pentose methylase activity
GO:0030743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (adenosine-2'-O-)-methyltransferase activity
GO:0030743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribosomal ribonucleate adenosine 2'-methyltransferase activity
GO:0030743	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thiostrepton-resistance methylase activity
REACT:R-DME-196857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK2 phosphorylates PanK (Drosophila melanogaster)
REACT:R-RNO-879377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Rattus norvegicus)
RHEA:51000	skos:altLabel	"ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase"
RHEA:51000	skos:altLabel	"RuBisCO methyltransferase"
RHEA:51000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine = [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine
RHEA:51000	skos:altLabel	"S-adenosyl-L-methionine:[3-phospho-D-glycerate-carboxy-lyase (dimerizing)]-lysine 6-N-methyltransferase"
RHEA:51000	skos:prefLabel	"[fructose-bisphosphate aldolase]-lysine N-methyltransferase"
RHEA:51000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[fructose-bisphosphate aldolase]-lysine N-methyltransferase"
REACT:R-XTR-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Xenopus tropicalis)
REACT:R-DRE-9008822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1D dephosphorylates RUNX2 (Danio rerio)
REACT:R-MMU-380316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of NuMA with microtubules (Mus musculus)
GO:0050189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate phosphatase activity
GO:0050189	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate phosphohydrolase activity
GO:0050189	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEP phosphatase activity
REACT:R-SSC-996727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST recruits the BHC complex (Sus scrofa)
REACT:R-BTA-354124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pPTK2 by SRC (Bos taurus)
REACT:R-MMU-9650858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Meglitinides bind ABCC8 (Mus musculus)
RHEA:39793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:26427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + UTP => ADP + CTP + 2 H(+) + L-glutamate + phosphate
REACT:R-SSC-6811431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Sus scrofa)
REACT:R-HSA-9757097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 N binds NLRP3 (Homo sapiens)
REACT:R-CEL-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Caenorhabditis elegans)
RHEA:44582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-decaprenylphenol + CO2 => 4-hydroxy-3-all-trans-decaprenylbenzoate + H(+)
REACT:R-XTR-6784319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,TYK2 phosphorylate JAK1,TYK2 (Xenopus tropicalis)
REACT:R-GGA-9674127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)
REACT:R-GGA-216045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I binds integrin alpha11beta1 (Gallus gallus)
RHEA:29218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + menaquinol-8 <=> menaquinone-8 + succinate
GO:0004369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alpha-glycerophosphate oxidase activity
GO:0004369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alpha-glycerol-3-phosphate oxidase activity
GO:0004369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate oxidase activity
GO:0004369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol-1-phosphate oxidase activity
GO:0004369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity
GO:0004369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol phosphate oxidase activity
GO:0004369	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glycerophosphate oxidase activity
REACT:R-DME-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Drosophila melanogaster)
REACT:R-BTA-173626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1r (Bos taurus)
RHEA:13131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP => cis-4-coumarate + UDP-alpha-D-glucose
REACT:R-GGA-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Gallus gallus)
REACT:R-SSC-5578777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMPK phosphorylates PLN (Sus scrofa)
REACT:R-CFA-8942101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 monoubiquitinates Histone H2B (Canis familiaris)
RHEA:68666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate
RHEA:57367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADH <=> (6S)-NADHX
RHEA:11801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) => AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)
REACT:R-DRE-198613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates p21Cip1 and p27Kip1 (Danio rerio)
RHEA:56859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + an aldehyde + H2O <=> a carboxylate + AH2 + H(+)
RHEA:30819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoin + H2O = allantoate + H(+)
REACT:R-HSA-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Homo sapiens)
REACT:R-MMU-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Mus musculus)
GO:0047483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)
GO:0047483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphoribosylimidazoleacetate synthetase activity
GO:0047483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazoleacetate-phosphoribosyldiphosphate ligase activity
RHEA:49906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2
REACT:R-HSA-4088162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXM1 binds CDC25A promoter (Homo sapiens)
REACT:R-DDI-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Dictyostelium discoideum)
REACT:R-CFA-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Canis familiaris)
REACT:R-DRE-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Danio rerio)
RHEA:72919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II
RHEA:58595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)
RHEA:25023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP + FMN + H(+) => CTP + riboflavin
REACT:R-RNO-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Rattus norvegicus)
REACT:R-HSA-451895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RG binds JAK3 (Homo sapiens)
REACT:R-BTA-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Bos taurus)
RHEA:70459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate
REACT:R-BTA-4085331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-1 SUMOylates PARK7 with SUMO1 (Bos taurus)
REACT:R-SPO-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Schizosaccharomyces pombe)
RHEA:42428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clavaminate = (3R,5R)-clavulanate-9-aldehyde
REACT:R-GGA-2395257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-hydroxylysino-norleucine cross-links (Gallus gallus)
REACT:R-DDI-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)
RHEA:40421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,11,15-tetramethylhexadecanoate + CoA + H(+) => H2O + phytanoyl-CoA
RHEA:54883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3R)-3-isopropenyl-6-oxoheptanoate + H(+)
RHEA:67527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine
RHEA:13382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + an acyl-CoA => a carboxylate + acetyl-CoA
REACT:R-DME-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Drosophila melanogaster)
RHEA:72506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + prostaglandin F2alpha(out) <=> glutarate(out) + prostaglandin F2alpha(in)
REACT:R-BTA-5617815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binds RAB3IP (Bos taurus)
RHEA:11975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(2+) + 6 H2O + O2 <=> 12 H(+) + 4 iron(III) oxide-hydroxide
REACT:R-PFA-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Plasmodium falciparum)
RHEA:29834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ni(2+)(in) <=> Ni(2+)(out)
RHEA:51797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycohumulone + dimethylallyl diphosphate => colupulone + diphosphate + H(+)
REACT:R-CFA-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Canis familiaris)
REACT:R-SCE-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-DME-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Drosophila melanogaster)
RHEA:48294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside Fuc-GM1 + GDP + H(+) => ganglioside GM1 + GDP-beta-L-fucose
RHEA:72373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(in) + succinate(out) => dehydroepiandrosterone 3-sulfate(out) + succinate(in)
REACT:R-CFA-5610758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Canis familiaris)
REACT:R-DRE-177933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by phosphorylated EGFR (Danio rerio)
REACT:R-RNO-9661799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)
GO:0090471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,15,9'-tri-cis-zeta-carotene isomerase activity
GO:0090471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	9,15,9'-tricis-zeta-carotene cis-trans-isomerase
REACT:R-HSA-5654748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR2 mutants (Homo sapiens)
RHEA:31836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose
REACT:R-BTA-2187330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)
RHEA:58683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + FADH2 <=> AH2 + FAD + H(+)
GO:0004024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Homo sapiens)
GO:0004024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol dehydrogenase activity, zinc-dependent
REACT:R-RNO-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Rattus norvegicus)
RHEA:39252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH => (11Z)-eicosenoyl-CoA + NADP(+)
RHEA:51970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2
REACT:R-BTA-8983876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds IL12RB2:IL12RB2 (Bos taurus)
REACT:R-HSA-5626699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK4 binds ODF2 in the centriole (Homo sapiens)
REACT:R-CFA-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Canis familiaris)
RHEA:34856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + iminodiacetonitrile => N-(cyanomethyl)glycine + NH4(+)
REACT:R-DDI-5696007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF3 ligates CoA-SH to VLCFA (Dictyostelium discoideum)
RHEA:66586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxy 3-oxocholestane + AH2 => 3-oxocholestane + A + H2O
REACT:R-DDI-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Dictyostelium discoideum)
RHEA:65229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol
RHEA:61555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0033786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptose-1-phosphate adenylyltransferase activity
GO:0033786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta-D-heptose 1-phosphate adenylyltransferase activity
GO:0033786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptose 1-phosphate adenyltransferase activity
REACT:R-SSC-213406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from LAT (Sus scrofa)
REACT:R-RNO-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Rattus norvegicus)
REACT:R-CFA-177927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)
REACT:R-XTR-426522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nonendonucleolytic RISC binds exactly matching target RNAs (Xenopus tropicalis)
RHEA:40973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:10981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine => D-serine
GO:0034549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-cyclopropylammelide alkylamino hydrolase activity
REACT:R-SSC-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)
REACT:R-RNO-5661517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC comlex binds OTULIN (Rattus norvegicus)
REACT:R-SCE-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)
REACT:R-HSA-5624132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Homo sapiens)
REACT:R-MMU-8878143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SMAD3 and SMAD4 (Mus musculus)
REACT:R-GGA-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Gallus gallus)
REACT:R-DRE-5693580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD52 with the RPA complex at resected DNA DSBs (Danio rerio)
GO:0000342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA cap 4 binding
REACT:R-XTR-6799202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Xenopus tropicalis)
RHEA:47969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 + H2O => ganglioside GM3 + N-acetyl-beta-D-galactosamine
RHEA:11637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin E1 => 15-oxoprostaglandin E1 + H(+) + NADPH
REACT:R-XTR-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Xenopus tropicalis)
REACT:R-HSA-5617492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)
RHEA:69201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate
RHEA:39049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0016780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphotransferase activity, for other substituted phosphate groups
REACT:R-XTR-449077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-16 is secreted (Xenopus tropicalis)
RHEA:23423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + H2O <=> alpha,alpha-trehalose + phosphate
REACT:R-MMU-9026967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 inhibitors binds VKORC1 dimer (Mus musculus)
GO:0106130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine phosphoribosyltransferase activity
REACT:R-RNO-2130500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of MHC II:Ii complex in to the plasma membrane (Rattus norvegicus)
RHEA:30747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + hexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + FADH2
RHEA:13908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP
GO:0047629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP aminohydrolase activity
GO:0047629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphate deaminase activity
GO:0047629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosinepyrophosphate deaminase activity
GO:0047629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP deaminase activity
RHEA:55985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile + UDP-alpha-D-glucose => (R)-prunasin + H(+) + UDP
REACT:R-HSA-3282876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective G6PC3 does not hydrolyze glucose 6-phosphate (Homo sapiens)
RHEA:17903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + xanthotoxin => S-adenosyl-L-methionine + xanthotoxol
REACT:R-GGA-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Gallus gallus)
RHEA:53310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:71201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(out) => L-ornithine(in)
REACT:R-HSA-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Homo sapiens)
RHEA:59165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] => AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]
RHEA:32849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
RHEA:66215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-omegaC5-CoA + O2 <=> asc-omegaDeltaC5-CoA + H2O2
RHEA:48612	skos:prefLabel	"molybdopterin synthase sulfurtransferase"
RHEA:48612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"molybdopterin synthase sulfurtransferase"
RHEA:48612	skos:altLabel	"molybdopterin synthase sulfurylase"
RHEA:48612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]
REACT:R-BTA-70333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KHK dimer phosphorylates Fru to Fru 1-P (Bos taurus)
REACT:R-RNO-9038161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Rattus norvegicus)
RHEA:36354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine
REACT:R-GGA-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)
REACT:R-SSC-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Sus scrofa)
GO:0016643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With an iron-sulfur protein as acceptor"
GO:0016643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor
GO:0016643	skos:prefLabel	"With an iron-sulfur protein as acceptor"
GO:0016643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor
REACT:R-RNO-9696323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNRs bind CNR agonists (Rattus norvegicus)
RHEA:16632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl-CoA <=> acetyl-CoA + glyoxylate
RHEA:48428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)
RHEA:10053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoate + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH
RHEA:36763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-BTA-2022381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)
RHEA:40929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O
RHEA:13931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + urea => agmatine + H2O
RHEA:61556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-2465917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerisation of 11c-retinyl to at-retinyl (Rattus norvegicus)
RHEA:56637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate
REACT:R-RNO-9640175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Rattus norvegicus)
REACT:R-GGA-433578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Gallus gallus)
REACT:R-SSC-5205672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncleaved Pink1 accumulates in damaged mitochondria (Sus scrofa)
RHEA:52577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + NAD(+) => (2E)-hexenoyl-CoA + H(+) + NADH
RHEA:72360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + succinate(out) => glutarate(out) + succinate(in)
REACT:R-SPO-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Schizosaccharomyces pombe)
RHEA:54556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-tRNA(His) + ATP + H(+) = a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate
GO:0140870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase inhibitor activity
REACT:R-SCE-4615873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates SUZ12 with SUMO1 (Saccharomyces cerevisiae)
REACT:R-MMU-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Mus musculus)
REACT:R-DRE-8866553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded CFTR is degraded by the 26S proteasome (Danio rerio)
REACT:R-DDI-1676204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Dictyostelium discoideum)
REACT:R-GGA-937075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated TAK1 leaves activated TLR receptor complex (Gallus gallus)
REACT:R-GGA-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)
REACT:R-XTR-1604350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14:TIMP2 binds proMMP2 (Xenopus tropicalis)
REACT:R-XTR-9670673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FIX is secreted (Xenopus tropicalis)
GO:0030781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-methylnorlaudanosoline + S-adenosyl-L-methionine = H(+) + nororientaline + S-adenosyl-L-homocysteine
GO:0030781	skos:prefLabel	"6-O-methylnorlaudanosoline 5'-O-methyltransferase"
GO:0030781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity
GO:0030781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-methylnorlaudanosoline 5'-O-methyltransferase activity
GO:0030781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-O-methylnorlaudanosoline 5'-O-methyltransferase"
REACT:R-CFA-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Canis familiaris)
REACT:R-DDI-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Dictyostelium discoideum)
GO:0009927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine phosphotransfer kinase activity
REACT:R-MMU-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Mus musculus)
RHEA:19586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH
REACT:R-XTR-9624668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDKN1A (p21) (Xenopus tropicalis)
REACT:R-XTR-173720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7 translocates to the plasma membrane (Xenopus tropicalis)
REACT:R-MMU-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Mus musculus)
REACT:R-DRE-5624956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds INPP5E (Danio rerio)
REACT:R-XTR-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Xenopus tropicalis)
REACT:R-HSA-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Homo sapiens)
REACT:R-RNO-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Rattus norvegicus)
REACT:R-HSA-2314566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking (Homo sapiens)
REACT:R-CFA-5689649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 (Canis familiaris)
REACT:R-DME-164832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase synthesizes ATP (Drosophila melanogaster)
RHEA:19284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen
REACT:R-MMU-171141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Mus musculus)
REACT:R-PFA-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Plasmodium falciparum)
REACT:R-GGA-9757686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDL (Gallus gallus)
REACT:R-HSA-6798317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Homo sapiens)
REACT:R-HSA-194187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:41167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)
GO:0005381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multicopper ferroxidase iron transport mediator activity
GO:0005381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron cation channel activity
GO:0005381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron transporter activity
GO:0005381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron ion transmembrane transporter activity
GO:0005381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane iron ion permease activity
GO:0005381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron channel activity
GO:0005381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane iron permease activity
GO:0005381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc, iron permease activity
REACT:R-CEL-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Caenorhabditis elegans)
REACT:R-GGA-750988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (z) reassociates with G beta:gamma (Gallus gallus)
REACT:R-DME-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)
RHEA:13181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + nitrate(out) = ADP + H(+) + nitrate(in) + phosphate
RHEA:13181	skos:prefLabel	"ABC-type nitrate transporter"
RHEA:13181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type nitrate transporter"
RHEA:37678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:35822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + NADP(+) <=> 7,8-dihydromethanopterin + H(+) + NADPH
REACT:R-DRE-5649711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 incises DNA strand 5' to the AP site (Danio rerio)
REACT:R-SPO-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Schizosaccharomyces pombe)
REACT:R-BTA-442749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the nucleus (Bos taurus)
REACT:R-CEL-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
REACT:R-MMU-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Mus musculus)
REACT:R-HSA-2318752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-26A microRNAs bind PTEN mRNA (Homo sapiens)
REACT:R-HSA-190258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c binds to FGF (Homo sapiens)
REACT:R-CEL-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Caenorhabditis elegans)
REACT:R-PFA-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Plasmodium falciparum)
RHEA:30846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formylmaleamate <=> formate + H(+) + maleamate
RHEA:39166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-CoA + NADP(+)
RHEA:65580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + TTP = H(+) + phosphate + TDP
RHEA:33725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine
REACT:R-DRE-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Danio rerio)
RHEA:20958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + phenylacetyl-CoA => 2-phenylacetate + ATP + CoA
RHEA:47875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + H2O <=> ganglioside GA1 + N-acetylneuraminate
REACT:R-HSA-5246478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOM binds retinoids (Homo sapiens)
REACT:R-RNO-8865667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPA hydrolyses sterol esters to sterols and fatty acids (Rattus norvegicus)
REACT:R-BTA-913451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3RB is phosphorylated on Ser-585 (Bos taurus)
REACT:R-XTR-2395314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysino-5-ketonorleucine cross-links (Xenopus tropicalis)
RHEA:37255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-asparagine + H2O = 2-oxosuccinamate + AH2 + NH4(+)
REACT:R-GGA-446372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  PARVA with TESK1 (Gallus gallus)
RHEA:60036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate = 3-hydroxy-3-methylhexanoate + L-glutamine
RHEA:20052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
REACT:R-HSA-1461971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Homo sapiens)
GO:0102562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyproline O-arbinofuranose transferase activity
REACT:R-MMU-391157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds SKAP2 (Mus musculus)
REACT:R-GGA-8938930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF2 (Gallus gallus)
REACT:R-RNO-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Rattus norvegicus)
REACT:R-XTR-9603419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds SRC (Xenopus tropicalis)
RHEA:37265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate => ATP + H2O + L-alanyl-L-aspartate(out)
RHEA:56386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2
REACT:R-SCE-3878123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initiation of SAHF formation (Saccharomyces cerevisiae)
REACT:R-DRE-159431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Danio rerio)
REACT:R-GGA-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Gallus gallus)
REACT:R-MMU-444606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R2/T1R3 dimer is a sweet taste receptor (Mus musculus)
RHEA:21183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol <=> D-glucose + indole-3-acetyl-1D-myo-inositol
RHEA:25568	skos:prefLabel	"nicotinate riboside kinase"
RHEA:25568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinate riboside kinase"
RHEA:25568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-ribosylnicotinate = ADP + H(+) + nicotinate beta-D-ribonucleotide
RHEA:25568	skos:altLabel	"ribosylnicotinic acid kinase"
REACT:R-BTA-4570489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO2 (Bos taurus)
REACT:R-PFA-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Plasmodium falciparum)
RHEA:25225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH
REACT:R-GGA-182990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty sequesters CBL away from active EGFR (Gallus gallus)
RHEA:38159	skos:prefLabel	"capreomycidine synthase"
RHEA:38159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-hydroxyarginine = (2S,3R)-capreomycidine + H2O
RHEA:38159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"capreomycidine synthase"
GO:1905574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 binding
REACT:R-DME-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Drosophila melanogaster)
REACT:R-RNO-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Rattus norvegicus)
RHEA:45087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Caenorhabditis elegans)
RHEA:28446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose(in) = 1-deoxy-D-xylulose(out)
REACT:R-HSA-70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Homo sapiens)
GO:0008960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligosaccharide glycerophosphotransferase activity
GO:0008960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglycerol transferase activity
GO:0008960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity
GO:0008960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglycerol transferase I
GO:0008960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity
REACT:R-HSA-166119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
REACT:R-XTR-5577050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Xenopus tropicalis)
GO:0004821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine translase activity
GO:0004821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-tRNA ligase activity
GO:0004821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidine:tRNAHis ligase (AMP-forming)
GO:0004821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidyl-transfer ribonucleate synthetase activity
GO:0004821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidyl-tRNA synthetase activity
REACT:R-SSC-1638803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)
GO:1990525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIR domain binding
GO:1990525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Baculovirus Inhibitor of apoptosis protein Repeat domain binding
REACT:R-DRE-8959462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Danio rerio)
RHEA:13498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-2-deoxy-D-gluconate + ATP => 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)
RHEA:15213	skos:altLabel	"lipoyl transsuccinylase"
RHEA:15213	skos:altLabel	"dihydrolipoamide succinyltransferase"
RHEA:15213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrolipoyllysine-residue succinyltransferase"
RHEA:15213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA
RHEA:15213	skos:altLabel	"dihydrolipolyl transsuccinylase"
RHEA:15213	skos:prefLabel	"dihydrolipoyllysine-residue succinyltransferase"
RHEA:15213	skos:altLabel	"dihydrolipoamide S-succinyltransferase"
RHEA:15213	skos:altLabel	"lipoic transsuccinylase"
RHEA:15213	skos:altLabel	"dihydrolipoyl transsuccinylase"
RHEA:15213	skos:altLabel	"succinyl-CoA:dihydrolipoate S-succinyltransferase"
RHEA:15213	skos:altLabel	"dihydrolipoic transsuccinylase"
RHEA:15213	skos:altLabel	"lipoate succinyltransferase"
RHEA:15213	skos:altLabel	"succinyl-CoA:dihydrolipoamide S-succinyltransferase"
REACT:R-SCE-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Saccharomyces cerevisiae)
REACT:R-RNO-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Rattus norvegicus)
REACT:R-SSC-8851804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET recruits GRB2-1:SOS1 (Sus scrofa)
REACT:R-RNO-5635855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Rattus norvegicus)
RHEA:24012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine
RHEA:30584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide => 2-demethylmenaquinone-8 + H2O + trimethylamine
RHEA:67302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one => (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one
REACT:R-CFA-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Canis familiaris)
RHEA:29633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + D-maltotriose => D-maltotetraose + H2O
RHEA:17033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase"
RHEA:17033	skos:altLabel	"biphenyl-2,3-dihydro-2,3-diol dehydrogenase"
RHEA:17033	skos:altLabel	"2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase"
RHEA:17033	skos:prefLabel	"cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase"
RHEA:17033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + H(+) + NADH
RHEA:31601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + thymine
RHEA:65838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O
REACT:R-DME-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Drosophila melanogaster)
REACT:R-RNO-8847875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF1:GTP binds Golgin TRIP11 (Rattus norvegicus)
REACT:R-BTA-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Bos taurus)
REACT:R-SPO-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)
RHEA:12221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-leucine + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)
RHEA:48498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose
REACT:R-GGA-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Gallus gallus)
RHEA:37773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA
REACT:R-HSA-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)
RHEA:49247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin E1 <=> 18-oxo-resolvin E1 + H(+) + NADH
RHEA:10788	skos:prefLabel	"dehydrogluconokinase"
RHEA:10788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dehydrogluconokinase"
RHEA:10788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + H(+)
RHEA:10788	skos:altLabel	"ketogluconokinase"
RHEA:52117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate
REACT:R-HSA-9017447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds PPARG gene promoter (Homo sapiens)
REACT:R-HSA-430135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds ADAP (Homo sapiens)
REACT:R-GGA-5336184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37L binds prosaposin (Gallus gallus)
REACT:R-CEL-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Caenorhabditis elegans)
RHEA:40077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	futalosine + NH4(+) => 6-amino-6-deoxyfutalosine + H(+) + H2O
RHEA:38727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol
REACT:R-CFA-199131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR binds CD226 (Canis familiaris)
REACT:R-DME-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Drosophila melanogaster)
REACT:R-MMU-3002811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates PLK1 (Mus musculus)
REACT:R-MMU-4090281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Mus musculus)
REACT:R-CEL-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Caenorhabditis elegans)
GO:0061751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral sphingomyelinase
GO:0061751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral SMase
GO:0061751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral sphingomyelin phosphodiesterase activity
REACT:R-CEL-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Caenorhabditis elegans)
REACT:R-HSA-5683836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPC gene produces pro-SFTPC protein (Homo sapiens)
REACT:R-CFA-8942302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP13 cleaves OPTC (Canis familiaris)
REACT:R-HSA-9033499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)
RHEA:42906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(748) in 23S rRNA + S-adenosyl-L-methionine
RHEA:26286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-5B + S-adenosyl-L-methionine => Co-precorrin-6A + S-adenosyl-L-homocysteine
RHEA:38919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphing-4-enine-phosphocholine = choline + H(+) + sphing-4-enine 1-phosphate
RHEA:39872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-2562594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated OPTN translocates to the nucleus (Homo sapiens)
RHEA:44382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + H(+) + S-adenosyl-L-homocysteine => a 3-demethylubiquinol + S-adenosyl-L-methionine
REACT:R-HSA-2559639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV sulfilimine cross-linking by peroxidasin (Homo sapiens)
REACT:R-DRE-5696968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP20, USP33 deubiquitinate ADRB2 (Danio rerio)
REACT:R-DME-209295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus (Drosophila melanogaster)
RHEA:16451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6')-acetylkanamycin B => acetyl-CoA + kanamycin B
REACT:R-HSA-8878193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the JAG1 gene promoter (Homo sapiens)
RHEA:68242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(out) + Na(+)(out) => L-methionine(in) + Na(+)(in)
REACT:R-SSC-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Sus scrofa)
REACT:R-MMU-173720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7 translocates to the plasma membrane (Mus musculus)
REACT:R-DME-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Drosophila melanogaster)
RHEA:46997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-N-methylmyosmine + H2O => 6-hydroxypseudooxynicotine
REACT:R-GGA-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Gallus gallus)
RHEA:29535	skos:altLabel	"dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase"
RHEA:29535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:29535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase"
RHEA:29535	skos:altLabel	"Dol-P-Man:Man7GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase"
RHEA:29535	skos:prefLabel	"dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase"
RHEA:12248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
RHEA:12248	skos:altLabel	"UDP-N-acetylglucosamine-enoylpyruvate reductase"
RHEA:12248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylmuramate dehydrogenase"
RHEA:12248	skos:altLabel	"uridine diphosphoacetylpyruvoylglucosamine reductase"
RHEA:12248	skos:altLabel	"UDP-N-acetylenolpyruvoylglucosamine reductase"
RHEA:12248	skos:altLabel	"UDP-GlcNAc-enoylpyruvate reductase"
RHEA:12248	skos:prefLabel	"UDP-N-acetylmuramate dehydrogenase"
RHEA:12248	skos:altLabel	"uridine diphospho-N-acetylglucosamine-enolpyruvate reductase"
REACT:R-HSA-210282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GPVI and FceRI gamma (Homo sapiens)
RHEA:27711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanosine => ADP + GMP + H(+)
GO:0030273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melanin-concentrating hormone receptor activity
GO:0030273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCH receptor
RHEA:41737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) => adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)
GO:0031014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	troponin T binding
REACT:R-HSA-8937989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRC1 complexes (Homo sapiens)
REACT:R-BTA-5666216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds TAX1BP3 (Bos taurus)
REACT:R-CFA-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Canis familiaris)
RHEA:22151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] <=> a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]
REACT:R-DRE-2065549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Danio rerio)
RHEA:18120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + O2 <=> H2O + L-dopaquinone
RHEA:48866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FADH2 + O2
RHEA:15272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylo-hex-3-ulonolactone <=> H(+) + L-ascorbate
REACT:R-SCE-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Saccharomyces cerevisiae)
RHEA:22210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + homogentisate + NAD(+) => 3-hydroxyphenylacetate + H(+) + NADH + O2
EC:3.1.1.76	skos:altLabel	"poly(HAMCL) depolymerase"
EC:3.1.1.76	skos:altLabel	"poly(HA) depolymerase"
EC:3.1.1.76	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"poly(3-hydroxyoctanoate) depolymerase"
EC:3.1.1.76	skos:altLabel	"poly[(R)-hydroxyalkanoic acid] depolymerase"
EC:3.1.1.76	skos:prefLabel	"poly(3-hydroxyoctanoate) depolymerase"
EC:3.1.1.76	skos:altLabel	"PHO depolymerase"
EC:3.1.1.76	skos:altLabel	"poly(3HO) depolymerase"
EC:3.1.1.76	skos:altLabel	"PHA depolymerase"
EC:3.1.1.76	skos:altLabel	"poly[(R)-3-hydroxyoctanoate] hydrolase"
REACT:R-XTR-6804955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDM2 (Xenopus tropicalis)
REACT:R-CFA-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Canis familiaris)
RHEA:53538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O
RHEA:38676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
RHEA:53746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H(+) + tRNA(Ala) => glycyl-tRNA(Ala) + H2O
RHEA:49114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine => phenazine-1-carboxylate + S-adenosyl-L-methionine
REACT:R-CEL-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Caenorhabditis elegans)
RHEA:70866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + L-threonine(in) + Na(+)(out) <=> L-glutamine(in) + L-threonine(out) + Na(+)(in)
REACT:R-DRE-870479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) binds to ubiquitinated SMAD4 (Danio rerio)
REACT:R-HSA-9611721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1-agonists bind ADRB1 (Homo sapiens)
REACT:R-MMU-158721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Mus musculus)
REACT:R-DRE-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Danio rerio)
REACT:R-HSA-9013567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HES1 gene expression is stimulated by NOTCH3 and STAT1 (Homo sapiens)
RHEA:17939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylglyoxal + phosphate => dihydroxyacetone phosphate
REACT:R-DRE-399936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of integrin activation by sequestering PIP5KIgamma (Danio rerio)
RHEA:13282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) => 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH
REACT:R-BTA-6798044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTG2 binds CCR4-NOT complex (Bos taurus)
REACT:R-BTA-9632182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates ESRs (Bos taurus)
RHEA:51650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2 => H2O + N(6)-acetyl-L-lysyl-[protein] + O2
RHEA:44077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + pentadecanoate => AMP + diphosphate + pentadecanoyl-CoA
REACT:R-HSA-9683622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA5 is translated to protein M (Homo sapiens)
REACT:R-GGA-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Gallus gallus)
RHEA:24754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite
RHEA:69643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2
REACT:R-DDI-379395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)
RHEA:57197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glycolate + H(+) + L-cysteinyl-[protein]
REACT:R-BTA-4088024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Bos taurus)
RHEA:43407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP
RHEA:11028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+)
REACT:R-MMU-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Mus musculus)
RHEA:38383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)
REACT:R-GGA-8950448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Gallus gallus)
RHEA:49144	skos:prefLabel	"dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase"
RHEA:49144	skos:altLabel	"TDP-4-keto-2,3,6-trideoxy-D-glucose 4-aminotransferase"
RHEA:49144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate
RHEA:49144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase"
REACT:R-BTA-9009309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STUB1 (Bos taurus)
REACT:R-RNO-6788999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HV1-mediated H+ transfer (Rattus norvegicus)
REACT:R-HSA-6783530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gp130:JAKs bind CNTFR (Homo sapiens)
RHEA:32546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> 1,8-cineole + diphosphate
GO:0070854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin VI heavy chain binding
RHEA:21038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA => 2 acetyl-CoA
REACT:R-CFA-6805943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A1 binds TLR4:LY96 (Canis familiaris)
RHEA:29524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)
RHEA:60421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triglucosyl-enterobactin => [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)
RHEA:66251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + IC-asc-C9-AMP <=> AMP + H(+) + IC-asc-C9-CoA
RHEA:66255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + IC-asc-C7 <=> AMP + diphosphate + IC-asc-C7-CoA
RHEA:29846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + propanoate <=> ADP + phosphate + propanoyl-CoA
GO:0032428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-N-acetylgalactosaminidase activity
GO:0032428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-N-acetylgalactosaminidase"
GO:0032428	skos:prefLabel	"beta-N-acetylgalactosaminidase"
REACT:R-PFA-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Plasmodium falciparum)
REACT:R-SPO-1482696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)
REACT:R-HSA-1358791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of USP8 by P-AKT (Homo sapiens)
GO:0045142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triplex DNA binding
REACT:R-DRE-5625416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anterograde IFT (Danio rerio)
REACT:R-HSA-5649686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL2 recognizes and binds 5-OHU-dsDNA (Homo sapiens)
RHEA:31507	skos:prefLabel	"pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)"
RHEA:31507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)"
RHEA:31507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate
RHEA:67461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate + A => AH2 + oxaloacetate
RHEA:68299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + L-seryl-[protein] <=> CoA + O-dodecanoyl-L-seryl-[protein]
RHEA:11520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol + UDP-alpha-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP
RHEA:11520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monoterpenol beta-glucosyltransferase"
RHEA:11520	skos:prefLabel	"monoterpenol beta-glucosyltransferase"
GO:0102191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity
RHEA:25031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + phosphate => ADP-beta-D-ribose 1''-phosphate + H2O
GO:0106345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate reductase activity
RHEA:58591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate + NADPH <=> (+)-vincadifformine + acetate + NADP(+)
RHEA:33300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-L-lysine + spermidine => [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
REACT:R-XTR-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Xenopus tropicalis)
REACT:R-RNO-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Rattus norvegicus)
RHEA:13213	skos:prefLabel	"succinate-semialdehyde dehydrogenase (NADP(+))"
RHEA:13213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH + succinate
RHEA:13213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinate-semialdehyde dehydrogenase (NADP(+))"
REACT:R-RNO-5607726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Rattus norvegicus)
RHEA:24635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 3 NADP(+) + NH4(+) <=> 5 H(+) + 3 NADPH + nitrite
REACT:R-RNO-417858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y14 receptor can bind to UDP-glucose (Rattus norvegicus)
REACT:R-DRE-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
REACT:R-MMU-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Mus musculus)
REACT:R-MMU-5621370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Mus musculus)
RHEA:36762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:22161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside => a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA
REACT:R-GGA-5632652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds CDON and PTCH (Gallus gallus)
RHEA:25728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:55172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + hexanoyl-CoA + O2 = 2-hydroxyhexanoyl-CoA + CO2 + succinate
RHEA:21928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH
RHEA:34140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(9)-tetrahydrocannabinolate + H(+) => CO2 + Delta(9)-tetrahydrocannabinol
REACT:R-GGA-8868659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
GO:0009486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinol + n H(+)(in) + O2 = 2 a ubiquinone + n H(+)(out) + 2 H2O
GO:0009486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ubiquinol oxidase (H(+)-transporting)"
GO:0009486	skos:altLabel	"cytochrome bo3 oxidase"
GO:0009486	skos:altLabel	"cytochrome bo oxidase"
GO:0009486	skos:prefLabel	"ubiquinol oxidase (H(+)-transporting)"
GO:0009486	skos:altLabel	"cytochrome bb3 oxidase"
GO:0009486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome bo(3) oxidase
GO:0009486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome o ubiquinol oxidase activity
GO:0009486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome bo3 ubiquinol oxidase activity
GO:0009486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome bo oxidase
REACT:R-HSA-2059926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPHP4 protein binds LATS proteins (Homo sapiens)
REACT:R-SPO-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Schizosaccharomyces pombe)
RHEA:44993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 2-methylbutanoyl-CoA => CoA + O-2-methylbutanoyl-(R)-carnitine
RHEA:16359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + fumarate => A + succinate
RHEA:68060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Xenopus tropicalis)
REACT:R-DRE-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Danio rerio)
RHEA:53682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2
RHEA:72606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + ATP + H(+) <=> (E)-sinapoyl-AMP + diphosphate
REACT:R-PFA-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Plasmodium falciparum)
REACT:R-DME-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Drosophila melanogaster)
RHEA:23301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + isopentenyl diphosphate => (2Z,6E)-farnesyl diphosphate + diphosphate
EC:2.3.2.25	skos:prefLabel	"N-terminal E2 ubiquitin-conjugating enzyme"
EC:2.3.2.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-terminal E2 ubiquitin-conjugating enzyme"
EC:2.3.2.25	skos:altLabel	"N-terminal ubiquitin-conjugating enzyme E2"
REACT:R-MMU-9020256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Mus musculus)
RHEA:55204	skos:altLabel	"FO synthase"
RHEA:55204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase"
RHEA:55204	skos:altLabel	"F0-synthase"
RHEA:55204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)
RHEA:55204	skos:prefLabel	"7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase"
REACT:R-DDI-71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Dictyostelium discoideum)
RHEA:70797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-lysine(in) => H(+)(in) + L-lysine(out)
RHEA:20074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allothreonine => acetaldehyde + glycine
REACT:R-MMU-1462039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-HNP1-4 are cleaved to biologically active defensin (Mus musculus)
REACT:R-XTR-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Xenopus tropicalis)
REACT:R-HSA-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
REACT:R-CFA-199203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK1/3/4 phosphorylate PanK (Canis familiaris)
REACT:R-MMU-158313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XII -> factor XIIa (Mus musculus)
REACT:R-BTA-8854604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D16 accelerates GTP hydrolysis by RAB4A (Bos taurus)
REACT:R-SSC-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Sus scrofa)
REACT:R-RNO-1878002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLTs transfer Xyl to core protein (Rattus norvegicus)
REACT:R-RNO-5696356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSCAR binds collagen and SP-D (Rattus norvegicus)
REACT:R-CEL-77329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Caenorhabditis elegans)
REACT:R-DRE-8874705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Danio rerio)
GO:0050150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoic acid decarboxylase activity
GO:0050150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	o-pyrocatechuate decarboxylase activity
GO:0050150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)
GO:0050150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-DHBA decarboxylase activity
GO:0050150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate decarboxylase activity
GO:0050150	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoate carboxy-lyase activity
REACT:R-RNO-9677320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS1 dimer binds PTGS1 Inhibitors (Rattus norvegicus)
RHEA:72176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) => 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)
RHEA:47403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(9Z-octadecenoyl)-CoA + CoA <=> (7Z)-hexadecenoyl-CoA + acetyl-CoA
REACT:R-MMU-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Mus musculus)
RHEA:24397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scytalone => 1,3,8-trihydroxynaphthalene + H2O
REACT:R-SSC-5656158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ elongates POLI-incorporated dNMP (Sus scrofa)
REACT:R-SSC-9731590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)
REACT:R-SSC-5696049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRM hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)
REACT:R-HSA-1067659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of hexameric IL-6 receptor (Homo sapiens)
RHEA:56390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2
RHEA:13245	skos:altLabel	"isocitrate glyoxylate-lyase"
RHEA:13245	skos:altLabel	"ICL"
RHEA:13245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate = glyoxylate + succinate
RHEA:13245	skos:altLabel	"isocitritase"
RHEA:13245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isocitrate lyase"
RHEA:13245	skos:prefLabel	"isocitrate lyase"
RHEA:13245	skos:altLabel	"isocitratase"
RHEA:13245	skos:altLabel	"isocitrase"
REACT:R-HSA-5690157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP16,USP21 deubiquitinate Histone H2A (Homo sapiens)
RHEA:58688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + O2 + rifamycin SV = H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide
RHEA:59835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]
RHEA:59127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + ATP + citrate <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate
REACT:R-DRE-450551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 binds translation and heat shock proteins (Danio rerio)
RHEA:44375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cr(6+) + 2 NADH + O2 <=> Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide
REACT:R-CFA-266089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Discoidal HDL binds membrane-associated free cholesterol (Canis familiaris)
REACT:R-SPO-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)
RHEA:48864	skos:prefLabel	"isobutylamine N-monooxygenase"
RHEA:48864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isobutylamine N-monooxygenase"
RHEA:48864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropan-1-amine + FMNH2 + O2 = FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine
RHEA:48864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropan-1-amine + FADH2 + O2 = FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine
REACT:R-BTA-427337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBD2 binds methylcytosine in chromatin (Bos taurus)
REACT:R-DDI-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Dictyostelium discoideum)
RHEA:48580	skos:prefLabel	"([Pyruvate, water dikinase] phosphate) phosphotransferase"
RHEA:48580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"([Pyruvate, water dikinase] phosphate) phosphotransferase"
RHEA:48580	skos:altLabel	"PSRP"
RHEA:48580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate, water dikinase]-phosphate + H(+) + phosphate = [pyruvate, water dikinase] + diphosphate
REACT:R-DRE-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Danio rerio)
RHEA:51397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin => CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin
RHEA:60467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
EC:1.6.5.2	skos:altLabel	"p-benzoquinone reductase"
EC:1.6.5.2	skos:prefLabel	"NAD(P)H dehydrogenase (quinone)"
EC:1.6.5.2	skos:altLabel	"NADH-menadione reductase"
EC:1.6.5.2	skos:altLabel	"vitamin K reductase"
EC:1.6.5.2	skos:altLabel	"dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone)"
EC:1.6.5.2	skos:altLabel	"naphthoquinone reductase"
EC:1.6.5.2	skos:altLabel	"DT-diaphorase"
EC:1.6.5.2	skos:altLabel	"diaphorase"
EC:1.6.5.2	skos:altLabel	"azoreductase"
EC:1.6.5.2	skos:altLabel	"NAD(P)H-quinone oxidoreductase"
EC:1.6.5.2	skos:altLabel	"quinone reductase"
EC:1.6.5.2	skos:altLabel	"menadione oxidoreductase"
EC:1.6.5.2	skos:altLabel	"NAD(P)H2 dehydrogenase (quinone)"
EC:1.6.5.2	skos:altLabel	"flavoprotein NAD(P)H-quinone reductase"
EC:1.6.5.2	skos:altLabel	"viologen accepting pyridine nucleotide oxidoreductase"
EC:1.6.5.2	skos:altLabel	"vitamin-K reductase"
EC:1.6.5.2	skos:altLabel	"NAD(P)H menadione reductase"
EC:1.6.5.2	skos:altLabel	"phylloquinone reductase"
EC:1.6.5.2	skos:altLabel	"reduced NAD(P)H dehydrogenase"
EC:1.6.5.2	skos:altLabel	"menadione reductase"
EC:1.6.5.2	skos:altLabel	"NAD(P)H dehydrogenase"
EC:1.6.5.2	skos:altLabel	"reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase"
EC:1.6.5.2	skos:altLabel	"NAD(P)H:(quinone-acceptor)oxidoreductase"
EC:1.6.5.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(P)H dehydrogenase (quinone)"
EC:1.6.5.2	skos:altLabel	"NAD(P)H-quinone dehydrogenase"
EC:1.6.5.2	skos:altLabel	"NAD(P)H: menadione oxidoreductase"
REACT:R-SSC-9006870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT phosphorylation (Sus scrofa)
RHEA:72888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] => ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0015412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	molybdate transporting ATPase activity
GO:0015412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type molybdate transporter activity
GO:0015412	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	molybdate porter activity
GO:0015412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled molybdate transmembrane transporter activity
GO:0015412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdate ABC transporter
GO:0015412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	molybdate-transporting ATPase activity
GO:0015412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	molybdate transmembrane-transporting ATPase activity
RHEA:49434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + lithocholate => cholate + lithocholoyl-CoA
RHEA:35871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-BTA-4570463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Bos taurus)
RHEA:62082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-sulfate + NADP(+)
REACT:R-SPO-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Schizosaccharomyces pombe)
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-hexose-1-phosphate uridylyltransferase activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-hexose-1-phosphate uridylyltransferase activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Gal-1-P uridylyltransferase activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uridyltransferase activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uridylyl removing enzyme activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uridyl transferase activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexose 1-phosphate uridyltransferase activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexose-1-phosphate uridylyltransferase activity
GO:0008108	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	galactose-1-phosphate uridylyltransferase activity
RHEA:32699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = beta-sesquiphellandrene + diphosphate
RHEA:32699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-sesquiphellandrene synthase"
RHEA:32699	skos:prefLabel	"beta-sesquiphellandrene synthase"
RHEA:32699	skos:altLabel	"Tps1"
RHEA:56177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O => 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)
REACT:R-GGA-1296043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of HCN channels (Gallus gallus)
RHEA:42606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O
RHEA:37500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DRE-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Danio rerio)
REACT:R-RNO-1296043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of HCN channels (Rattus norvegicus)
REACT:R-DRE-2187261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC12 (SCARA4) binds ligands (Danio rerio)
RHEA:15628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-6B + NAD(+) <=> Co-precorrin-6A + H(+) + NADH
RHEA:52044	skos:prefLabel	"mogroside IE synthase"
RHEA:52044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mogrol + UDP-alpha-D-glucose = H(+) + mogroside IE + UDP
RHEA:52044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mogroside IE synthase"
RHEA:52044	skos:altLabel	"mogrol C-3 hydroxyl glycosyltransferase"
RHEA:52044	skos:altLabel	"UGT74AC1"
RHEA:50812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:17034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl-2,3-diol + H(+) + NADH
REACT:R-DRE-5654673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Danio rerio)
REACT:R-BTA-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Bos taurus)
REACT:R-DME-5669158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF2 binds PAK1 (Drosophila melanogaster)
RHEA:45586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + H2O => 3-hydroxybutanoyl-CoA
REACT:R-RNO-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Rattus norvegicus)
REACT:R-MMU-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Mus musculus)
REACT:R-HSA-3321975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NuA4 complex acetylates histone H2A, HIST1H4 (Homo sapiens)
REACT:R-SSC-5685985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Sus scrofa)
REACT:R-MMU-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Mus musculus)
REACT:R-CEL-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)
REACT:R-HSA-5250210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Homo sapiens)
REACT:R-MMU-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Mus musculus)
REACT:R-CFA-9629492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves spiroiminodihydantoin (Canis familiaris)
RHEA:64478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => 4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate
RHEA:66091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + oxaloacetate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate
REACT:R-BTA-1474197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP1,3,8,13,PRSS2 (Bos taurus)
RHEA:30174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]
REACT:R-SPO-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Schizosaccharomyces pombe)
REACT:R-RNO-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Rattus norvegicus)
REACT:R-RNO-9796387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Rattus norvegicus)
RHEA:20125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-209365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT92E dimer transports from the cytosol to the nucleus (Drosophila melanogaster)
REACT:R-SSC-140216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PMAIP1 (NOXA) to mitochondria (Sus scrofa)
RHEA:20077	skos:prefLabel	"tRNA (guanosine(18)-2'-O)-methyltransferase"
RHEA:20077	skos:altLabel	"tRNA (Gm18) 2'-O-methyltransferase"
RHEA:20077	skos:altLabel	"tRNA (Gm18) methyltransferase"
RHEA:20077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (guanosine(18)-2'-O)-methyltransferase"
RHEA:20077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-72231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Cleavage and Polyadenylation Complex (Mus musculus)
REACT:R-SPO-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Schizosaccharomyces pombe)
RHEA:21028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]
REACT:R-DME-432237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Drosophila melanogaster)
RHEA:56717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate
REACT:R-PFA-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Plasmodium falciparum)
RHEA:32308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => H2O + leukotriene A4
RHEA:58160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate = diphosphate + dolabradiene
RHEA:58160	skos:prefLabel	"dolabradiene synthase"
RHEA:58160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolabradiene synthase"
REACT:R-MMU-5218891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomer binds MLKL (Mus musculus)
REACT:R-HSA-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Homo sapiens)
REACT:R-SSC-6810843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin binds periplakin (Sus scrofa)
REACT:R-MMU-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Mus musculus)
GO:0047355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	teichoic acid glycerol transferase activity
GO:0047355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPglycerol glycerophosphotransferase activity
GO:0047355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(glycerol phosphate) polymerase activity
GO:0047355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CGPTase activity
GO:0047355	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	teichoic-acid synthase activity
GO:0047355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity
GO:0047355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glycerol glycerophosphotransferase activity
GO:0047355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphate synthetase activity
GO:0047355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoglycerol glycerophosphotransferase activity
RHEA:10483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxy-L-glutamate <=> 4-hydroxy-2-oxoglutarate + L-glutamate
REACT:R-GGA-177479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Axonal transport of NGF:Trk complexes (Gallus gallus)
REACT:R-XTR-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Xenopus tropicalis)
REACT:R-CFA-2029465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
RHEA:35927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	paromamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endodeoxyribonuclease RUS activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo X3
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SpCCe1 Holliday junction resolvase activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Holliday junction endonuclease CCE1 activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Holliday junction resolvase activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SpCCe1 holliday junction resolvase
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RusA holliday junction resolvase
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	resolving enzyme CCE1 activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crossover junction endoribonuclease activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RuvC endonuclease activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RusA endonuclease activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Holliday junction nuclease activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Hje endonuclease activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RusA Holliday junction resolvase activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Holliday junction-cleaving endonuclease activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endonuclease X3 activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crossover junction endodeoxyribonuclease activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endonuclease VII activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Endo X3 activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endonuclease RuvC activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Holliday junction-resolving endoribonuclease activity
GO:0008821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cruciform-cutting endonuclease activity
RHEA:38582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine => ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine
REACT:R-HSA-1791056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CCL2 (Homo sapiens)
REACT:R-CFA-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Canis familiaris)
RHEA:57395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine <=> 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)
GO:0001875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide immune receptor activity
GO:0001875	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lipopolysaccharide receptor activity
GO:0001875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS receptor activity
GO:0001875	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endotoxin receptor activity
REACT:R-RNO-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Rattus norvegicus)
RHEA:71010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + L-tryptophan(in) <=> L-phenylalanine(in) + L-tryptophan(out)
REACT:R-HSA-9725009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM-ALK translocates to the nucleus (Homo sapiens)
REACT:R-CFA-8983059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Canis familiaris)
REACT:R-BTA-3132737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate ETS1 and ETS2 (Bos taurus)
REACT:R-SSC-429613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-DRE-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Danio rerio)
RHEA:10062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-D-tryptophan => acetyl-CoA + D-tryptophan
GO:0000247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-8 sterol isomerase activity
GO:0000247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-8-delta-7 sterol isomerase activity
REACT:R-CFA-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Canis familiaris)
REACT:R-SSC-8848124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAT3 (Sus scrofa)
RHEA:14190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophan + O2 => N-formyl-D-kynurenine
RHEA:48158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate => ganglioside GQ1b (d18:1(4E)) + H2O
REACT:R-DME-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Drosophila melanogaster)
REACT:R-SCE-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Saccharomyces cerevisiae)
RHEA:22313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(methylsulfanyl)-D-ribose + ATP => ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate
RHEA:31274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + naphthalene-1,2-diol
REACT:R-CFA-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Canis familiaris)
REACT:R-SSC-6783552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM binds LIFR:JAKs,OSMR:JAKs (Sus scrofa)
REACT:R-RNO-5694427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA3 binds procollagen VII (Rattus norvegicus)
REACT:R-CFA-9639287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2 binds L-leucine and dissociates from GATOR2 (Canis familiaris)
GO:0034068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside nucleotidyltransferase activity
GO:0034068	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptomycin adenylylase activity
GO:0034068	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aminoglycoside adenylyltransferase activity
GO:0034068	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptomycin adenyltransferase activity
GO:0034068	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptomycin adenylyltransferase activity
GO:0034068	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptomycin-spectinomycin adenylyltransferase activity
GO:0034068	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptomycin adenylate synthetase activity
RHEA:31079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisovaleryl-CoA = 3-methyl-(2E)-butenoyl-CoA + H2O
RHEA:70066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-174441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Sus scrofa)
REACT:R-HSA-5668481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
REACT:R-MMU-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Mus musculus)
RHEA:32908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine
RHEA:49311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside nLc4Cer(d18:0) + L-fucose
REACT:R-BTA-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Bos taurus)
REACT:R-GGA-190245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1b binds to FGF (Gallus gallus)
REACT:R-SSC-9707051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN1 binds BRCA1:BARD1 heterodimer (Sus scrofa)
REACT:R-RNO-8857577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 facilitates PTK6 autophosphorylation (Rattus norvegicus)
REACT:R-DRE-419490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATP to P2X receptors (Danio rerio)
GO:0102696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-zeatin UDP glycosyltransferase activity
REACT:R-HSA-1564120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII degradation by MMP1,2,3 (Homo sapiens)
RHEA:50139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (9Z)-octadecenoate + H2O <=> (9Z)-octadecenoate + ethanol + H(+)
RHEA:57374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADPHX => H2O + NADPH
RHEA:34352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranial + H2O + NAD(+) => geranate + 2 H(+) + NADH
GO:0086040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:hydrogen antiporter activity involved in regulation of cardiac muscle cell membrane potential
GO:0086040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
REACT:R-HSA-9731072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 3a tetramer induces potassium efflux (Homo sapiens)
REACT:R-HSA-2671850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 Phosphoryates STAT3 in Response to Leptin (Homo sapiens)
RHEA:13919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-menthone + H(+) + NADPH => (-)-menthol + NADP(+)
REACT:R-CEL-5662662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosinase oxidises tyrosine to dopaquinone (Caenorhabditis elegans)
REACT:R-HSA-2984226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NEK9 (Homo sapiens)
REACT:R-HSA-194718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Homo sapiens)
RHEA:38967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine(in) + ATP + H2O = ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate
RHEA:62350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + notoamide C => H(+) + NADPH + notoamide E + O2
REACT:R-CFA-9733973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts bind FABP6 (Canis familiaris)
REACT:R-BTA-2161282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastic fibres bind associated proteins (Bos taurus)
RHEA:48478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate => ganglioside GT1a (d18:1(4E)) + H2O
GO:0018535	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotine oxidase activity
GO:0018535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotine dehydrogenase activity
GO:0018535	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-nicotine oxidase activity
GO:0018535	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotine:acceptor 6-oxidoreductase (hydroxylating)
GO:0018535	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotine:(acceptor) 6-oxidoreductase (hydroxylating)
REACT:R-HSA-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Homo sapiens)
RHEA:41661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + NAD(+) => NADH + sanguinarine
REACT:R-XTR-1168638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated IKK phosphorylates I-kappaB (Xenopus tropicalis)
GO:0036380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase activity
GO:0036380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcNAc-P-P-Und synthase activity
GO:0036380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase activity
GO:0036380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity
GO:0036380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity
GO:0036380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity
REACT:R-HSA-5649802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)
REACT:R-RNO-9670014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor VIIIa dissociates  (Rattus norvegicus)
REACT:R-RNO-6786190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMBL hydrolyses OM to OLMS (Rattus norvegicus)
RHEA:15515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + keto-D-tagatose 6-phosphate => ATP + keto-D-tagatose
REACT:R-HSA-205328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other tyrosine kinases with p-KIT (Homo sapiens)
REACT:R-BTA-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Bos taurus)
REACT:R-DME-5654569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS2 (Drosophila melanogaster)
GO:0008865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-fructose 6-phosphotransferase activity
GO:0008865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructokinase activity
GO:0008865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose(D-mannose)kinase activity
GO:0008865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructokinase (phosphorylating)
GO:0008865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructokinase activity
RHEA:36870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CEL-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)
RHEA:64507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine <=> 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine
RHEA:51374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(9Z-hexadecenoyl)-glycine => (9Z)-hexadecenoyl-CoA + glycine
RHEA:71326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-asparagine(out) + 2 Na(+)(out) <=> chloride(in) + L-asparagine(in) + 2 Na(+)(in)
REACT:R-GGA-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Gallus gallus)
RHEA:24547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)
RHEA:59021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)
REACT:R-MMU-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Mus musculus)
REACT:R-BTA-8940388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPLD1 hydrolyses GPI-anchors from proteins (Bos taurus)
REACT:R-PFA-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Plasmodium falciparum)
REACT:R-RNO-5654224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds PLCG1 (Rattus norvegicus)
RHEA:19766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol => 3-hydroxypropanal + H2O
RHEA:33631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA
REACT:R-HSA-5685341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex stabilizes RAD51 filament (Homo sapiens)
REACT:R-XTR-1549564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)
REACT:R-MMU-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Mus musculus)
REACT:R-XTR-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Xenopus tropicalis)
RHEA:33061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoamide + H(+) + NADH => (R)-dihydrolipoamide + NAD(+)
REACT:R-XTR-166038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-bound CD14 binds LPS (Xenopus tropicalis)
REACT:R-HSA-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Homo sapiens)
RHEA:43242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O
REACT:R-DRE-5692755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates MAPK6 (Danio rerio)
EC:3.4.21.41	skos:prefLabel	"complement subcomponent C1r"
EC:3.4.21.41	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"complement subcomponent C1r"
REACT:R-CFA-8853734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Canis familiaris)
REACT:R-SPO-9638127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G6P to G1P (Schizosaccharomyces pombe)
RHEA:71215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + thiocyanate(out) = 2 Na(+)(in) + thiocyanate(in)
RHEA:50684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-glutamylanilide hydrolase"
RHEA:50684	skos:prefLabel	"gamma-glutamylanilide hydrolase"
RHEA:50684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-phenyl-L-glutamine = aniline + H(+) + L-glutamate
REACT:R-XTR-74707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IRS to insulin receptor (Xenopus tropicalis)
RHEA:46109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 => (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)
RHEA:64863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine <=> (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine
GO:0016722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on metal ions
GO:0016722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, oxidizing metal ions
GO:0016722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, reducing metal ions
REACT:R-BTA-2028735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind WWTR1 (TAZ) (Bos taurus)
REACT:R-MMU-429415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to integrin alphaIIb beta3 (Mus musculus)
REACT:R-RNO-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Rattus norvegicus)
REACT:R-DDI-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Dictyostelium discoideum)
REACT:R-RNO-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Rattus norvegicus)
REACT:R-CFA-450690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Canis familiaris)
RHEA:69129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-leucine => 4-methyl-2-oxopentanoate + glycine
REACT:R-SSC-2752115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds CD44 (Sus scrofa)
REACT:R-BTA-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)
REACT:R-RNO-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Rattus norvegicus)
REACT:R-SSC-8851011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 polyubiquitinates PTEN (Sus scrofa)
REACT:R-HSA-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Homo sapiens)
REACT:R-MMU-9707516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM dissociates from MetHb (Mus musculus)
RHEA:71006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(in) + L-phenylalanine(out) <=> L-histidine(out) + L-phenylalanine(in)
REACT:R-RNO-199299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO transcription factors (Rattus norvegicus)
GO:0047639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol oxidase activity
GO:0047639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethanol oxidase activity
GO:0047639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + O2 = an aldehyde + H2O2
GO:0047639	skos:prefLabel	"alcohol oxidase"
GO:0047639	skos:altLabel	"methanol oxidase"
GO:0047639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AOX activity
GO:0047639	skos:altLabel	"AOX"
GO:0047639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alcohol:oxygen oxidoreductase activity
GO:0047639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol oxidase"
RHEA:30986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]
REACT:R-MMU-5632649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds GAS1 and PTCH (Mus musculus)
RHEA:49632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate = (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)
RHEA:30652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + O2 + urate => allantoin + CO2 + H2O2
REACT:R-CFA-156808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Canis familiaris)
RHEA:61624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + cadaverine = 5-aminopentanal + L-glutamate
GO:0009496	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome b6f
GO:0009496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plastoquinol--plastocyanin reductase activity
GO:0009496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome b6f complex activity
GO:0009496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	plastoquinol:oxidized-plastocyanin oxidoreductase activity
GO:0009496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	plastoquinol-plastocyanin reductase activity
GO:0009496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	plastoquinol/plastocyanin oxidoreductase activity
GO:0033444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAG codon-amino acid adaptor activity
GO:0033444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine tRNA
RHEA:28677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactose => alpha-D-galactose
EC:1.8.4.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enzyme-thiol transhydrogenase (glutathione-disulfide)"
EC:1.8.4.7	skos:prefLabel	"enzyme-thiol transhydrogenase (glutathione-disulfide)"
EC:1.8.4.7	skos:altLabel	"enzyme-thiol transhydrogenase (oxidized-glutathione)"
EC:1.8.4.7	skos:altLabel	"thiol:disulfide oxidoreductase"
EC:1.8.4.7	skos:altLabel	"[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase"
EC:1.8.4.7	skos:altLabel	"glutathione-dependent thiol:disulfide oxidoreductase"
RHEA:60765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone => cinerin II + CoA
RHEA:71513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phylloquinone(in) => phylloquinone(out)
RHEA:44026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H2O => (3R)-3-hydroxydodecanoyl-CoA
RHEA:13048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Homo sapiens)
REACT:R-RNO-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Rattus norvegicus)
RHEA:39239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-triacontenoyl-CoA + H(+) + NADPH = NADP(+) + triacontanoyl-CoA
REACT:R-BTA-3257122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Bos taurus)
RHEA:66334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate(in) => L-aspartate(out)
REACT:R-CFA-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Canis familiaris)
REACT:R-DRE-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Danio rerio)
RHEA:34449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH => dTDP-6-deoxy-beta-L-talose + NAD(+)
RHEA:69892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + thymidine(out) => Na(+)(in) + thymidine(in)
RHEA:38028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + hydrocaffeoyl-CoA => (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate
REACT:R-BTA-448744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20RA binds IL20RB (Bos taurus)
RHEA:34681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate => ATP + methylphosphonate
REACT:R-GGA-433131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC1 co-transports dicarboxylic acids and a sodium ion (Gallus gallus)
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucuronic acid transferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPGT activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phenyl-UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-phenylphenol glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ciramadol UDP-glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	4-methylumbelliferone UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	3-OH androgenic UDPGT activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPGA-glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	17beta-hydroxysteroid UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	4-nitrophenol UDP-glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-naphthol-UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uridine diphosphoglucuronate-estriol glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-nitrophenol UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine 5'-diphosphoglucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bilirubin UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bilirubin uridine diphosphoglucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PNP-UDPGT
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UDP glucuronate-estradiol-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	morphine glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	4-hydroxybiphenyl UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	estrone UDPglucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	17-OH steroid UDPGT activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	17-beta-hydroxysteroid UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-nitrophenylglucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-nitrophenol UDP-glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bilirubin glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	3alpha-hydroxysteroid UDP-glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPGA transferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UDP glucuronate-estriol glucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	estriol UDPglucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucuronosyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bilirubin monoglucuronide glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-hydroxybiphenyl UDP glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pnp-UDPGT activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	1-naphthol glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	4-nitrophenol UDPGT activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UDP-glucuronate-bilirubin glucuronyltransferase activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GT activity
GO:0015020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bilirubin UDPGT activity
RHEA:60361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + H(+) + oxidized coenzyme F420-0 => dehydro coenzyme F420-0 + FMNH2
REACT:R-XTR-1236941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of receptor bound antigen into clathrin coted vesicles (Xenopus tropicalis)
REACT:R-DRE-5205682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin promotes the ubiquitination of mitochondrial substrates (Danio rerio)
REACT:R-GGA-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Gallus gallus)
REACT:R-DRE-2514867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Danio rerio)
RHEA:49586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythrulose 1-phosphate => D-erythrulose 1-phosphate
REACT:R-RNO-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)
REACT:R-CEL-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
REACT:R-MMU-2022379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Mus musculus)
RHEA:29118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinone-8 + NADPH <=> menaquinol-8 + NADP(+)
REACT:R-BTA-1234167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of HIF:CBP:p300 complex at promoters (Bos taurus)
REACT:R-BTA-2533950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP14, TMPRSS6 (Bos taurus)
REACT:R-DRE-193743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)
REACT:R-SCE-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Saccharomyces cerevisiae)
RHEA:19421	skos:prefLabel	"2-hydroxypropyl-CoM lyase"
RHEA:19421	skos:altLabel	"EaCoMT"
RHEA:19421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxypropyl-CoM lyase"
RHEA:19421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxypropyl-coenzyme M = (S)-1,2-epoxypropane + coenzyme M
RHEA:19421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxypropyl-coenzyme M = (R)-1,2-epoxypropane + coenzyme M
RHEA:19421	skos:altLabel	"coenzyme M-epoxyalkane ligase"
EC:5.4.2.12	skos:altLabel	"2,3-diphosphoglycerate-independent phosphoglycerate mutase"
EC:5.4.2.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglycerate mutase (2,3-diphosphoglycerate-independent)"
EC:5.4.2.12	skos:altLabel	"phosphoglycerate phosphomutase"
EC:5.4.2.12	skos:altLabel	"cofactor independent phosphoglycerate mutase"
EC:5.4.2.12	skos:altLabel	"phosphoglyceromutase"
EC:5.4.2.12	skos:prefLabel	"phosphoglycerate mutase (2,3-diphosphoglycerate-independent)"
REACT:R-DRE-1474158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCHFR binds to GCH1 and negatively regulates its activity (Danio rerio)
REACT:R-CEL-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Caenorhabditis elegans)
RHEA:16356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + taurine <=> L-glutamate + sulfoacetaldehyde
REACT:R-DRE-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Danio rerio)
RHEA:71673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamine(in) + H(+)(in) => glycyl-L-glutamine(out) + H(+)(out)
REACT:R-HSA-2033474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b mutants bind an expanded range of ligands (Homo sapiens)
REACT:R-MMU-202241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SLP-76 to Gads (Mus musculus)
REACT:R-CEL-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Caenorhabditis elegans)
REACT:R-DRE-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Danio rerio)
REACT:R-XTR-70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine => urocanate + NH4+ (Xenopus tropicalis)
RHEA:45848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydodecanoyl-CoA + NADP(+) = 3-oxododecanoyl-CoA + H(+) + NADPH
RHEA:12477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-glutamate => formate + L-glutamate
RHEA:27584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyleneglutarate + H2O => (S)-2-hydroxymethylglutarate
RHEA:56083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-L-serine + CDP-choline <=> [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)
REACT:R-DME-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Drosophila melanogaster)
RHEA:59512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylsalicylate + L-seryl-[protein] = O-acetyl-L-seryl-[protein] + salicylate
REACT:R-SSC-6799695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX5,6 reduce H2O2 to H2O (Sus scrofa)
REACT:R-HSA-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Homo sapiens)
RHEA:24955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate
REACT:R-HSA-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Homo sapiens)
REACT:R-CFA-9027607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Canis familiaris)
REACT:R-HSA-879930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 is recruited by JAK2 (Homo sapiens)
REACT:R-CFA-5685366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y-SHC (Canis familiaris)
REACT:R-MMU-4420128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates SHB (Mus musculus)
REACT:R-HSA-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
RHEA:32774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate <=> 2,6-dioxo-6-phenylhexa-3-enoate
REACT:R-HSA-9692228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMRT1 binds the SOX9 gene (Homo sapiens)
GO:0034353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA 5'-diphosphatase activity
GO:0034353	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA pyrophosphohydrolase activity
REACT:R-BTA-4754176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR3-histone H3 (Bos taurus)
REACT:R-SSC-8951500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CANX from nonameric complex (Sus scrofa)
REACT:R-DRE-445797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLK (MLCK) Active Calmodulin Binding (Danio rerio)
RHEA:39926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine
RHEA:51873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + umbelliferone => diphosphate + osthenol
RHEA:50019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine
RHEA:28639	skos:prefLabel	"(-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]"
RHEA:28639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]"
RHEA:28639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = (-)-gamma-cadinene + diphosphate
RHEA:28639	skos:altLabel	"(-)-gamma-cadinene cyclase"
EC:1.1.1.266	skos:altLabel	"dTDP-4-keto-6-deoxyglucose reductase"
EC:1.1.1.266	skos:prefLabel	"dTDP-4-dehydro-6-deoxyglucose reductase"
EC:1.1.1.266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-dehydro-6-deoxyglucose reductase"
REACT:R-HSA-4085372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)
RHEA:56926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein] => ATP + L-threonyl-[Goodpasture antigen-binding protein]
REACT:R-RNO-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Rattus norvegicus)
REACT:R-CFA-8849900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs1-3 bind each other in cis interactions (Canis familiaris)
REACT:R-DME-5195402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LPIN (Drosophila melanogaster)
RHEA:18805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein dithiol oxidoreductase (disulfide-forming)"
RHEA:18805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-disulfide + [protein]-dithiol = [DsbA protein]-dithiol + [protein]-disulfide
RHEA:18805	skos:prefLabel	"protein dithiol oxidoreductase (disulfide-forming)"
REACT:R-DRE-1170539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor is internalized (Danio rerio)
RHEA:46327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + A <=> 3-oxochola-4,17-dien-22-oyl-CoA + AH2
REACT:R-BTA-5419273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of GTP and dissociation of 28S and 39S subunits (Bos taurus)
REACT:R-RNO-139905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAD protein to mitochondria (Rattus norvegicus)
RHEA:39456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)
RHEA:34664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-1234173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)
REACT:R-RNO-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Rattus norvegicus)
REACT:R-DRE-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Danio rerio)
REACT:R-DRE-83677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4 deamination of cytidine (Danio rerio)
RHEA:36875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA
RHEA:62486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:37985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dimethyl-6-phytylbenzene-1,4-diol => gamma-tocopherol
REACT:R-DME-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Drosophila melanogaster)
RHEA:51746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A
REACT:R-XTR-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Xenopus tropicalis)
RHEA:62130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + dGDP => a 2'-deoxyribonucleoside 5'-phosphate + dGTP
REACT:R-DRE-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Danio rerio)
REACT:R-HSA-203893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Microprocessor complex cleaves pri-miRNA to pre-miRNA (Homo sapiens)
REACT:R-HSA-445077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 from C-domain to P-domain (Homo sapiens)
REACT:R-CEL-9035227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN2 binds CysS248-MPST (Caenorhabditis elegans)
RHEA:20930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-disulfide + a quinol => [DsbA protein]-dithiol + a quinone
RHEA:32599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = 3-isopropenyl-6-oxoheptanoate + H(+)
RHEA:53989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-threonyl-[myosin light chain] => L-threonyl-[myosin light chain] + phosphate
RHEA:41172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O => 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)
REACT:R-SSC-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Sus scrofa)
RHEA:16004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N(6)-methyl-AMP <=> IMP + methylamine
REACT:R-CFA-109998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Canis familiaris)
RHEA:27428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate
REACT:R-SSC-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Sus scrofa)
RHEA:70993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-mannopyranose(out) => H(+)(in) + L-mannopyranose(in)
RHEA:70238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside
REACT:R-BTA-72095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internal Methylation of mRNA (Bos taurus)
REACT:R-XTR-8874718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA binds alpha-TOH (Xenopus tropicalis)
RHEA:18144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + trans-cyclohexane-1,2-diol <=> 2-hydroxycyclohexan-1-one + H(+) + NADH
RHEA:51117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(6) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine
REACT:R-XTR-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Xenopus tropicalis)
REACT:R-CEL-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Caenorhabditis elegans)
REACT:R-CFA-9027043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)
RHEA:39233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytriacontanoyl-CoA + NADP(+) => 3-oxo-triacontanoyl-CoA + H(+) + NADPH
GO:0070335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic acid binding
GO:0070335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate binding
REACT:R-MMU-8875540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 recruits CRK,CRKL to MET (Mus musculus)
RHEA:25740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Xenopus tropicalis)
RHEA:44431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol
RHEA:28981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + nitrite(out) => H(+)(out) + nitrite(in)
RHEA:39553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH
RHEA:66473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E,10E,14E)-geranylfarnesol => 18-episcalar-17(25)-en-19-ol
RHEA:19064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nitrite <=> H(+) + NADPH + nitrate
GO:0043028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type endopeptidase regulator activity involved in apoptotic process
GO:0043028	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	caspase regulator activity
REACT:R-CFA-6805573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I/type II heterodimers form tetramers (Canis familiaris)
RHEA:19326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + quinolin-4-ol => H2O + NAD(+) + quinoline-3,4-diol
REACT:R-BTA-1433456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs (Bos taurus)
REACT:R-DRE-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Danio rerio)
REACT:R-GGA-5683801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates BRCA1 (Gallus gallus)
REACT:R-RNO-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)
GO:0047428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylacetonitrilase activity
GO:0047428	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylacetonitrile aminohydrolase activity
REACT:R-XTR-265301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticotropin cleavage from POMC (Xenopus tropicalis)
REACT:R-CFA-9029680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-7 translocates to the nucleus (Canis familiaris)
RHEA:28797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)
REACT:R-DRE-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Danio rerio)
RHEA:64542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base
REACT:R-CEL-199202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphopantetheine conjugation of the ACP domain of FAS (Caenorhabditis elegans)
RHEA:45579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ethylmalonyl-CoA <=> (2S)-methylsuccinyl-CoA
RHEA:45348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine
REACT:R-CFA-420173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR1,CRHR2-1 binds CRH,UCN (Canis familiaris)
RHEA:52422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + S-sulfo-L-cysteine => O-phospho-L-serine + thiosulfate
RHEA:61928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-miconazole(in) + ATP + H2O = (R)-miconazole(out) + ADP + H(+) + phosphate
RHEA:54995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + FMN + H2O + L-glutamate + O2 <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)
REACT:R-GGA-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)
GO:0018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DL-2 haloacid dehalogenase activity
REACT:R-BTA-429449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk activation leads to SLP-76 activation (Bos taurus)
REACT:R-RNO-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Rattus norvegicus)
RHEA:30015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
RHEA:49687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NAD(+)
RHEA:52452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:48029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triacetin => acetate + diacetylglycerol + H(+)
REACT:R-XTR-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Xenopus tropicalis)
RHEA:22796	skos:prefLabel	"hamamelose kinase"
RHEA:22796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hamamelose kinase"
RHEA:22796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate + H(+)
REACT:R-XTR-4088141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PPP2R2A dephosphorylates FOXM1 (Xenopus tropicalis)
RHEA:18214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + CTP + H(+) => CDP-D-glucose + diphosphate
RHEA:30107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH
GO:0043737	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Escherichia coli endodeoxyribonuclease V activity
GO:0043737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endodeoxyribonuclease V
GO:0043737	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNase V activity
GO:0043737	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endonuclease V activity
GO:0043737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonuclease V activity
REACT:R-HSA-6789325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of IL13-downregulated extracellular proteins (Homo sapiens)
REACT:R-CFA-2730840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Canis familiaris)
REACT:R-HSA-8948594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-19a microRNA binds VAPA mRNA (Homo sapiens)
RHEA:39791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Xenopus tropicalis)
REACT:R-MMU-6814885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
GO:0031730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR5 chemokine receptor binding
GO:0031730	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR5 chemokine receptor ligand
RHEA:68527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> beta-bisabolene + diphosphate
REACT:R-SSC-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Sus scrofa)
REACT:R-DRE-8876472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 binds CHOL (Danio rerio)
REACT:R-MMU-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Mus musculus)
RHEA:38766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
REACT:R-MMU-688136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates RIP2 (Mus musculus)
REACT:R-RNO-937044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 (Rattus norvegicus)
REACT:R-CEL-5696564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP25 deubiquitinates DDX58 (Caenorhabditis elegans)
REACT:R-MMU-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Mus musculus)
REACT:R-XTR-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Xenopus tropicalis)
RHEA:58987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + H2O + O2 <=> acrylate + H(+) + H2O2
RHEA:18422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + chloramphenicol => chloramphenicol 3-acetate + CoA
REACT:R-SSC-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Sus scrofa)
REACT:R-DRE-400434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds fatty acids (Danio rerio)
RHEA:19900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 L-arginine + 3 NADPH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide
RHEA:31756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxepin-2(3H)-ylideneacetyl-CoA + H2O => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde
RHEA:16610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine
RHEA:54025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 => (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate
RHEA:40393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2,3-diacyl-sn-glycerol + CoA => 1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA
RHEA:34158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose
RHEA:37044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-glutamate(out) => ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate
REACT:R-CFA-9632034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GlcA to chondroitin (Canis familiaris)
REACT:R-MMU-1678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses CS/HS precursor (Mus musculus)
REACT:R-BTA-2473594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP15 (Bos taurus)
REACT:R-CFA-378513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Canis familiaris)
REACT:R-SPO-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Schizosaccharomyces pombe)
REACT:R-SCE-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Saccharomyces cerevisiae)
GO:0140811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2A-R3 citrullination
GO:0140811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AR3 arginine deiminase activity
GO:0140811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine deiminase activity (H2A-R3 specific)
GO:0140811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A-R3 arginine deiminase activity
RHEA:50636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O
RHEA:51027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene-4-sulfonate <=> 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)
GO:0052656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine aminotransferase activity
GO:0052656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine transaminase activity
REACT:R-SSC-8875443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates LRIG1 (Sus scrofa)
REACT:R-SPO-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Schizosaccharomyces pombe)
RHEA:69747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + succinyl-CoA = (indol-3-yl)acetyl-CoA + succinate
REACT:R-DME-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Drosophila melanogaster)
RHEA:16145	skos:altLabel	"cytidine monophosphoacetylneuraminate monooxygenase"
RHEA:16145	skos:altLabel	"CMP-N-acetylneuraminate hydroxylase"
RHEA:16145	skos:prefLabel	"CMP-N-acetylneuraminate monooxygenase"
RHEA:16145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CMP-N-acetylneuraminate monooxygenase"
RHEA:16145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:16145	skos:altLabel	"CMP-Neu5Ac hydroxylase"
RHEA:16145	skos:altLabel	"CMP-N-acetylneuraminic acid hydroxylase"
REACT:R-RNO-158744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Rattus norvegicus)
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleic acid binding transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gene-specific transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA binding transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence-specific DNA binding transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type DNA binding transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-binding transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metal ion regulated sequence-specific DNA binding transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcription factor activity, metal ion regulated sequence-specific DNA binding
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
GO:0003700	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
RHEA:44258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine
RHEA:30912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin + H2O => a carboxylate + sphing-4-enine-phosphocholine
RHEA:63706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP => mycophenolate + UDP-alpha-D-glucuronate
GO:0000339	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	binding to mRNA cap
GO:0000339	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mRNA cap binding
GO:0000339	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	snRNA cap binding
GO:0000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA cap binding
REACT:R-SSC-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Sus scrofa)
RHEA:13473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan + NAD(+) = H(+) + indole-3-pyruvate + NADH + NH4(+)
REACT:R-DME-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Drosophila melanogaster)
RHEA:27656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2 => 2-oxobutanoate + H(+) + pyruvate
RHEA:64016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)
REACT:R-MMU-174786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Mus musculus)
RHEA:22086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 NH4(+) + pyruvate => (S)-2,3-diaminopropanoate + H(+) + H2O
RHEA:42765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:39610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH <=> (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)
REACT:R-HSA-9029155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 (Homo sapiens)
REACT:R-RNO-5687090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6 phosphorylates NCOA3 (Rattus norvegicus)
RHEA:56816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose
REACT:R-DRE-5668520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26Sproteasome degrades K48polyUb-NIK (Danio rerio)
REACT:R-GGA-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Gallus gallus)
REACT:R-SSC-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Sus scrofa)
RHEA:41249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-CFA-5577234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Canis familiaris)
RHEA:12012	skos:prefLabel	"thiamine kinase"
RHEA:12012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine = ADP + H(+) + thiamine phosphate
RHEA:12012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiamine kinase"
RHEA:19651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-aspartyl-tRNA(Asp) => ATP + L-aspartate + tRNA(Asp)
RHEA:10249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => diphosphate + dUMP + H(+)
RHEA:37906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxytryprostatin B + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tryprostatin A
RHEA:35042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine(in) <=> spermidine(out)
EC:3.4.24.29	skos:altLabel	"Staphylococcus aureus neutral proteinase"
EC:3.4.24.29	skos:prefLabel	"aureolysin"
EC:3.4.24.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aureolysin"
REACT:R-CEL-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Caenorhabditis elegans)
RHEA:52773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate
REACT:R-RNO-174209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Rattus norvegicus)
RHEA:63841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + tert-butyl hydroperoxide => [thioredoxin]-disulfide + H2O + tert-butanol
REACT:R-SCE-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Saccharomyces cerevisiae)
REACT:R-XTR-8983384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Xenopus tropicalis)
EC:1.1.9.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a copper protein as acceptor"
EC:1.1.9.-	skos:prefLabel	"With a copper protein as acceptor"
REACT:R-DME-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Drosophila melanogaster)
RHEA:13076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 3'-diphosphate 5'-triphosphate + H2O <=> guanosine 3',5'-bis(diphosphate) + H(+) + phosphate
RHEA:24302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)yrinate a,c diamide + FMNH2 => 2 cob(I)yrinate a,c diamide + FMN + 3 H(+)
RHEA:52253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine
REACT:R-SCE-2168079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL (GWL) phosphorylates ARPP19 (Saccharomyces cerevisiae)
RHEA:31501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose
REACT:R-MMU-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Mus musculus)
REACT:R-MMU-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Mus musculus)
REACT:R-GGA-69891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of CHEK2 by ATM (Gallus gallus)
GO:0018501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-chlorobenzene dihydrodiol dehydrogenase activity
REACT:R-CFA-159728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-prothrombin to prothrombin (Canis familiaris)
RHEA:63111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxy-ilicicolin A epoxide <=> ascofuranol
REACT:R-CFA-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Canis familiaris)
REACT:R-DME-196350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Drosophila melanogaster)
RHEA:54963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + dinor-OPDA <=> AMP + dinor-OPDA-CoA + diphosphate
REACT:R-RNO-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-GGA-351963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A18 transports Gly from extracellular region to cytosol (Gallus gallus)
REACT:R-CFA-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Canis familiaris)
RHEA:64845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + benzoyl-CoA => (2E)-geranyl benzoate + CoA
RHEA:19445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxyindole + O2 = anthranilate + CO2 + H(+)
RHEA:19445	skos:prefLabel	"2,3-dihydroxyindole 2,3-dioxygenase"
RHEA:19445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-dihydroxyindole 2,3-dioxygenase"
RHEA:13067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate => ATP + H2O
REACT:R-HSA-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)
REACT:R-RNO-8876312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Rattus norvegicus)
RHEA:18006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threitol + NADP(+) => D-erythrulose + H(+) + NADPH
REACT:R-BTA-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Bos taurus)
GO:0052604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocopherol cyclase activity
RHEA:47165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxyzymosterol + NAD(+) => CO2 + NADH + zymosterone
REACT:R-MMU-2395320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 binds integrins (Mus musculus)
RHEA:62512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + melatonin + O2 = 2-hydroxymelatonin + CO2 + succinate
REACT:R-GGA-5689544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds INO80 complex (Gallus gallus)
RHEA:60781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A15 + O2 => CO2 + gibberellin A24 + H2O + succinate
REACT:R-BTA-5358340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoproteolytic cleavage of Hh precursors (Bos taurus)
GO:0016984	skos:altLabel	"carboxydismutase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose bisphosphate carboxylase/oxygenase activity
GO:0016984	skos:altLabel	"ribulose 1,5-bisphosphate carboxylase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose 1,5-bisphosphate carboxylase/oxygenase activity
GO:0016984	skos:altLabel	"ribulose 1,5-diphosphate carboxylase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose 1,5-bisphosphate carboxylase activity
GO:0016984	skos:altLabel	"diphosphoribulose carboxylase"
GO:0016984	skos:altLabel	"ribulose bisphosphate carboxylase/oxygenase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribulose-bisphosphate carboxylase"
GO:0016984	skos:altLabel	"RuBisCO"
GO:0016984	skos:altLabel	"ribulose diphosphate carboxylase/oxygenase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxydismutase activity
GO:0016984	skos:altLabel	"D-ribulose-1,5-bisphosphate carboxylase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose diphosphate carboxylase activity
GO:0016984	skos:prefLabel	"ribulose-bisphosphate carboxylase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 1,5-diphosphate carboxylase activity
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RuBP carboxylase activity
GO:0016984	skos:altLabel	"ribulose diphosphate carboxylase"
GO:0016984	skos:altLabel	"RuBP carboxylase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose 1,5-diphosphate carboxylase activity
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose-1,5-bisphosphate carboxylase activity
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose-bisphosphate carboxylase activity
GO:0016984	skos:altLabel	"ribulose 1,5-diphosphate carboxylase/oxygenase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RuBisCO activity
GO:0016984	skos:altLabel	"ribulose 1,5-bisphosphate carboxylase/oxygenase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphoribulose carboxylase activity
GO:0016984	skos:altLabel	"D-ribulose 1,5-diphosphate carboxylase"
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose 1,5-diphosphate carboxylase/oxygenase activity
GO:0016984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribulose diphosphate carboxylase/oxygenase activity
REACT:R-BTA-264435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the COP1-p53 complex (Bos taurus)
RHEA:54797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) => an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH
REACT:R-MMU-9756134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Mus musculus)
REACT:R-XTR-1296043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of HCN channels (Xenopus tropicalis)
RHEA:32693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-beta-ocimene + diphosphate => (2E)-geranyl diphosphate
REACT:R-CFA-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Canis familiaris)
REACT:R-SPO-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Schizosaccharomyces pombe)
REACT:R-BTA-73806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIR + CO2 => CAIR (Bos taurus)
REACT:R-SPO-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
RHEA:62118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + oxaloacetate => H2O + iminosuccinate
RHEA:28260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate
REACT:R-SCE-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Saccharomyces cerevisiae)
REACT:R-DDI-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Dictyostelium discoideum)
REACT:R-CEL-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Caenorhabditis elegans)
REACT:R-CFA-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Canis familiaris)
REACT:R-GGA-5696997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP24 deubiquitinates DDB2 (Gallus gallus)
RHEA:16996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] <=> 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]
RHEA:56224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP
RHEA:30759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytosine + H(+) + H2O = NH4(+) + thymine
RHEA:21212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate
RHEA:29647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltopentaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotetraose
REACT:R-SSC-449115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Sus scrofa)
REACT:R-MMU-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Mus musculus)
RHEA:60947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + S-adenosyl-L-methionine <=> H(+) + isorhamnetin + S-adenosyl-L-homocysteine
REACT:R-SSC-1433506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APS (Sus scrofa)
REACT:R-MMU-5625426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde IFT (Mus musculus)
RHEA:38836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-XTR-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Xenopus tropicalis)
REACT:R-HSA-5624949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the anterograde IFT train (Homo sapiens)
RHEA:63642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => (R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+)
RHEA:46591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcidiol + H2O + 2 oxidized [adrenodoxin]
REACT:R-SCE-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)
RHEA:71438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic L-alpha-amino acid(in) + L-thyroxine(out) <=> an aromatic L-alpha-amino acid(out) + L-thyroxine(in)
REACT:R-MMU-2022073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen triple helix formation (Mus musculus)
REACT:R-XTR-373087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR6 binds CCL20 ligand (Xenopus tropicalis)
RHEA:59959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkanimidothioate <=> a nitrile + sulfate + sulfur
RHEA:51801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadlupulone + dimethylallyl diphosphate => adlupulone + diphosphate + H(+)
REACT:R-HSA-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Homo sapiens)
REACT:R-MMU-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Mus musculus)
REACT:R-HSA-5672948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK3 phosphorylates KSR1 (Homo sapiens)
RHEA:42495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 <=> 3'-N-debenzoyltaxol + A + H2O
REACT:R-RNO-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Rattus norvegicus)
RHEA:11586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ornithine => L-ornithine
REACT:R-SSC-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)
RHEA:31610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhodopin <=> all-trans-lycopene + H2O
REACT:R-DME-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)
REACT:R-RNO-170810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Rattus norvegicus)
GO:0016632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a cytochrome as acceptor"
GO:0016632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor
GO:0016632	skos:prefLabel	"With a cytochrome as acceptor"
REACT:R-DRE-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Danio rerio)
REACT:R-SPO-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)
REACT:R-XTR-6803523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Xenopus tropicalis)
RHEA:40527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinol + 4 H(+)(in) + O2(in) = 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)
RHEA:40527	skos:prefLabel	"ubiquinol oxidase (electrogenic, proton-motive force generating)"
RHEA:40527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ubiquinol oxidase (electrogenic, proton-motive force generating)"
RHEA:40527	skos:altLabel	"cytochrome bd-I oxidase"
REACT:R-HSA-2203479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2 (FEEL-2) binds ligands (Homo sapiens)
RHEA:24033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose => 6-O-alpha-D-glucopyranosyl-D-fructose
REACT:R-RNO-9021170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen stimulates dimerization of plasma membrane estrogen receptors (Rattus norvegicus)
RHEA:64254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetradecanoylglycine => glycine + tetradecanoyl-CoA
REACT:R-CFA-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Canis familiaris)
REACT:R-HSA-216723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)
RHEA:26186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O
REACT:R-SSC-8876615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB13 GEFs exchange GTP for GDP on RAB13 (Sus scrofa)
REACT:R-HSA-5625849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM1A binds KLK2 and KLK3 promoters (Homo sapiens)
REACT:R-DRE-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Danio rerio)
REACT:R-DRE-5654729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Danio rerio)
REACT:R-GGA-73945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAS-mediated dimerization of procaspase-8 (Gallus gallus)
RHEA:63611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apelin-17 + H2O <=> apelin-16 + L-phenylalanine
REACT:R-BTA-9034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 dimers trans-autophosphorylate (Bos taurus)
REACT:R-DDI-6814153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADO oxidises 2AET to HTAU (Dictyostelium discoideum)
REACT:R-HSA-1251922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 phosphorylation by p-EGFR:p-ERBB2 (Homo sapiens)
RHEA:52647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,4-lactone 5-phosphate + H2O <=> 5-phospho-D-xylonate + H(+)
REACT:R-CEL-1592314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Caenorhabditis elegans)
REACT:R-DRE-77277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Danio rerio)
RHEA:60232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate
REACT:R-MMU-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Mus musculus)
REACT:R-PFA-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Plasmodium falciparum)
REACT:R-HSA-1602446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Homo sapiens)
REACT:R-RNO-1433415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 (Rattus norvegicus)
REACT:R-HSA-167083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)
RHEA:63437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)
RHEA:38704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:62186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + labd-13(16),14-diene-9-ol => peregrinol diphosphate
REACT:R-HSA-373733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin binds contactin-1:CASPR complex (Homo sapiens)
RHEA:48104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
RHEA:37240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-UMP + H2O => H(+) + uridine 2'-phosphate
REACT:R-HSA-1504188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD recruits DVL to the receptor complex (Homo sapiens)
RHEA:67239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolyl-CoA + propanoyl-CoA <=> (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA
REACT:R-DRE-190065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TrkA receptor internalizes to endosomes (Danio rerio)
REACT:R-BTA-9626832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Bos taurus)
REACT:R-DRE-5251955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Danio rerio)
REACT:R-HSA-9035517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective AVP mutants do not bind AVPR2 (Homo sapiens)
REACT:R-DRE-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Danio rerio)
REACT:R-HSA-213406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from LAT (Homo sapiens)
GO:0102080	skos:altLabel	"arylacetyl-CoA N-acyltransferase"
GO:0102080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + phenylacetyl-CoA = CoA + H(+) + phenylacetylglycine
GO:0102080	skos:prefLabel	"glycine N-phenylacetyltransferase"
GO:0102080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetyl-coenzyme A:glycine N-acyltransferase activity
GO:0102080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine N-phenylacetyltransferase"
GO:0102080	skos:altLabel	"arylacetyltransferase"
REACT:R-CEL-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)
REACT:R-DME-69299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds geminin (Drosophila melanogaster)
REACT:R-DRE-8852317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GTSE1 (Danio rerio)
REACT:R-SSC-216058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Sus scrofa)
REACT:R-CFA-6785732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases bind monoubiquitinated ID2 complex (Canis familiaris)
RHEA:42318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:70310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine
REACT:R-DRE-5579023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA2(869-1464) binds KAT6A(1-1118) (Danio rerio)
REACT:R-MMU-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Mus musculus)
RHEA:43869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) => a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)
RHEA:41929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-[ACP] + H(+) + NADPH => NADP(+) + octadecanoyl-[ACP]
RHEA:49297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + L-sorbose 1-phosphate(in)
REACT:R-PFA-5618098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Plasmodium falciparum)
REACT:R-MMU-1482696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)
RHEA:44537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-BTA-9012689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Bos taurus)
RHEA:60399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-SSC-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Sus scrofa)
RHEA:21394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + 2 H(+) + NADH => 2-phenylacetaldehyde + H2O + NAD(+)
REACT:R-XTR-5226964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKH transports PPi from cytosol to extracellular region (Xenopus tropicalis)
RHEA:70582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:46578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + NADP(+) + stigmasterol => H(+) + NADPH + O2 + sitosterol
GO:0050120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylhexosamine dehydrogenase activity
GO:0050120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity
GO:0050120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylhexosamine 1-dehydrogenase activity
GO:0050120	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-hexosamine dehydrogenase activity
RHEA:69817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone => cathasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:17943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-cis-aconitate + H2O => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate
RHEA:36397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrodesmosterol + H(+) + NADPH => 7-dehydrocholesterol + NADP(+)
REACT:R-RNO-8938300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vanin hydrolyses pantetheine to PanK, 2AET (Rattus norvegicus)
REACT:R-GGA-421472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 delta-aminolevulinate => porphobilinogen + 2 H2O (Gallus gallus)
GO:0140938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3 methyltransferase activity
GO:0140938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H3 methylation
GO:0140938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3 methylase activity
REACT:R-PFA-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Plasmodium falciparum)
REACT:R-SSC-170131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Sus scrofa)
REACT:R-BTA-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Bos taurus)
RHEA:71079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] = cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55660	skos:altLabel	"beta-carotene ketolase"
RHEA:55660	skos:altLabel	"beta-C-4 oxygenase"
RHEA:55660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-beta-carotene + 2 O2 = 2 A + echinenone + 3 H2O
RHEA:55660	skos:prefLabel	"beta-carotene 4-ketolase"
RHEA:55660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + echinenone + 2 O2 = 2 A + canthaxanthin + 3 H2O
RHEA:55660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-carotene 4-ketolase"
RHEA:24664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide
RHEA:27698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-galactose + phosphate = beta-L-galactose 1-phosphate + GDP + H(+)
REACT:R-HSA-8941701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Homo sapiens)
REACT:R-XTR-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Xenopus tropicalis)
RHEA:18457	skos:prefLabel	"3,4-dihydroxy-2-butanone-4-phosphate synthase"
RHEA:18457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,4-dihydroxy-2-butanone-4-phosphate synthase"
RHEA:18457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)
RHEA:18457	skos:altLabel	"L-3,4-dihydroxybutan-2-one-4-phosphate synthase"
RHEA:18457	skos:altLabel	"DHBP synthase"
REACT:R-HSA-4084912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arresten binds integrin alpha1beta1 (Homo sapiens)
RHEA:26521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoyl-CoA <=> acryloyl-CoA + H2O
REACT:R-CFA-434836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk/Lck phosphorylate LAT (Canis familiaris)
RHEA:38292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)
RHEA:72627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out)
RHEA:66773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + uroporphyrin I(in) => ADP + H(+) + phosphate + uroporphyrin I(out)
REACT:R-SSC-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)
REACT:R-XTR-8855564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Xenopus tropicalis)
REACT:R-HSA-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Homo sapiens)
RHEA:61351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + estrone 3-sulfate(in) + H2O <=> ADP + estrone 3-sulfate(out) + H(+) + phosphate
REACT:R-DME-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Drosophila melanogaster)
RHEA:71356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) => 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)
RHEA:44585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-XTR-9668597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase:primase binds G-strand of the telomere (Xenopus tropicalis)
REACT:R-DRE-446684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Danio rerio)
RHEA:16357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + succinate = AH2 + fumarate
REACT:R-RNO-9029580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Rattus norvegicus)
REACT:R-DME-203680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)
RHEA:60471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
REACT:R-RNO-9011748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R binds JAK1 (Rattus norvegicus)
REACT:R-RNO-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Rattus norvegicus)
GO:0001049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase V core binding
REACT:R-MMU-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Mus musculus)
GO:0097604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	temperature-activated cation channel activity
GO:0097604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	temperature-gated cation channel activity
GO:0097604	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heat-activated cation channel activity
GO:0097604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	temperature-dependent cation channel activity
GO:0097604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	temperature gated cation channel activity
REACT:R-GGA-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Gallus gallus)
RHEA:10433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acetamidomethylene)succinate + H(+) + 2 H2O => acetate + CO2 + NH4(+) + succinate semialdehyde
RHEA:53461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate
RHEA:45324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine
RHEA:67771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:46945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) => H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH
REACT:R-DRE-212713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLC-gamma1 dissociates from EGFR (Danio rerio)
REACT:R-BTA-9755937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces LAN to 24,25-dhLAN (Bos taurus)
REACT:R-DRE-111742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)
GO:0005366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol:hydrogen symporter activity
GO:0005366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol:proton symporter activity
GO:0005366	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogen/myo-inositol transporter activity
REACT:R-MMU-191072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Cx43 (Mus musculus)
REACT:R-XTR-9674529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds to TBXA2R (Xenopus tropicalis)
REACT:R-MMU-2076383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3ST1 sulfates GlcN at C3 in heparan sulfate (Mus musculus)
REACT:R-SCE-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Saccharomyces cerevisiae)
REACT:R-CFA-5250930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH recruits histone acetyltransferases (Canis familiaris)
REACT:R-BTA-5696945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates CCP110,ARRB (Bos taurus)
RHEA:57437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guaethol + O2 + reduced [NADH--hemoprotein reductase] => acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
REACT:R-DRE-159101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Danio rerio)
RHEA:18847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxopropanoate + H(+) + NADH => (R)-glycerate + NAD(+)
RHEA:15006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A1 + O2 => CO2 + gibberellin A8 + succinate
REACT:R-CFA-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Canis familiaris)
REACT:R-DME-3928612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KALRN exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
RHEA:55040	skos:altLabel	"3-oxoacyl-acyl carrier protein synthase I"
RHEA:55040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-ketoacyl-[acyl-carrier-protein] synthase II"
RHEA:55040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]
RHEA:55040	skos:altLabel	"KAS II"
RHEA:55040	skos:altLabel	"beta-ketoacyl-ACP synthase II"
RHEA:55040	skos:altLabel	"KASII"
RHEA:55040	skos:prefLabel	"beta-ketoacyl-[acyl-carrier-protein] synthase II"
REACT:R-SSC-2161999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Sus scrofa)
REACT:R-BTA-8985153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OASL binds DDX58 (Bos taurus)
REACT:R-CFA-1250380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Canis familiaris)
RHEA:36556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + sphinganine => CoA + H(+) + N-eicosanoylsphinganine
REACT:R-CFA-6788556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to NDUFV1, V2 (Canis familiaris)
RHEA:58509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O => (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
RHEA:46279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + H(+) <=> (S)-lactate + CO2
REACT:R-HSA-9022462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 mutants R133C ,D121G, R133H and S134F do not bind 5hmC-DNA (Homo sapiens)
RHEA:10071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
REACT:R-HSA-196125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of isocaproaldehyde from the mitochondrial matrix to the cytosol (Homo sapiens)
REACT:R-DME-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Drosophila melanogaster)
REACT:R-HSA-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Homo sapiens)
RHEA:16214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP
REACT:R-SCE-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Saccharomyces cerevisiae)
GO:0010485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H4 histone acetylase activity
GO:0010485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H4 histone acetyltransferase activity
GO:0010485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4 acetyltransferase activity
RHEA:69327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate <=> 4-methylsulfanylbutyl isothionate + H(+) + sulfate
REACT:R-DRE-9667952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 is deacetylated by SIRT2 (Danio rerio)
GO:0008106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol dehydrogenase (NADP+) activity
GO:0008106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP-aldehyde reductase activity
GO:0008106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde reductase (NADPH2) activity
GO:0008106	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde reductase (NADPH) activity
GO:0008106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol:NADP dehydrogenase activity
GO:0004126	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine aminohydrolase activity
GO:0004126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine deaminase activity
GO:0004126	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytosine nucleoside deaminase activity
GO:0004126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4 deamination of cytidine (Homo sapiens)
EC:7.2.3.-	skos:prefLabel	"Linked to the hydrolysis of diphosphate"
EC:7.2.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Linked to the hydrolysis of diphosphate"
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylglycinamide ribotide amidotransferase activity
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylformylglycineamidine synthetase activity
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosylformylglycinamidine synthase activity
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylglycinamide ribonucloetide amidotransferase activity
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylformylglycinamidine synthetase activity
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FGAM synthase activity
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FGARAT activity
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FGAR amidotransferase activity
GO:0004642	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FGAM synthetase activity
RHEA:61454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11a-hydroxy-oxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + oxytetracycline
REACT:R-HSA-9733545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids bind ALB (Homo sapiens)
RHEA:58158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + 4 Na(+)(out) + phosphate => ATP + H2O + 4 Na(+)(in)
RHEA:36338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + H2O + NAD(+) <=> D-glucarate + 2 H(+) + NADH
REACT:R-RNO-2076611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3STs sulfate GlcN at C3 in heparan sulfate (Rattus norvegicus)
REACT:R-MMU-5678313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Mus musculus)
REACT:R-HSA-8865693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 gene expression is repressed by STAT5 (Homo sapiens)
REACT:R-HSA-9013963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis  (Homo sapiens)
REACT:R-MMU-5683425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53BP1 at DNA DSBs (Mus musculus)
REACT:R-GGA-5218806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN autophosphorylates (Gallus gallus)
REACT:R-CEL-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Caenorhabditis elegans)
RHEA:57862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + scopoletin => (E)-6-hydroxyferuloyl-CoA
REACT:R-DRE-2453855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)
REACT:R-HSA-9038029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxysterol binds ESR1, ESR2 (Homo sapiens)
REACT:R-RNO-5685605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF7 binds SLAMF7 (Rattus norvegicus)
REACT:R-HSA-5211405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anthrax lef cleaves target cell MAP2K6 (MEK6) (Homo sapiens)
GO:0106348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U2 snRNA adenosine m6 methytransferase activity
REACT:R-SSC-5684261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K8 is phosphorylated (Sus scrofa)
REACT:R-SSC-196350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Sus scrofa)
REACT:R-MMU-432897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ILK interacts with beta-1 integrin (Mus musculus)
REACT:R-HSA-975608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP2:atROL and FACYLs to atREs (Homo sapiens)
RHEA:29211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + inosine(in) = H(+)(in) + inosine(out)
REACT:R-CFA-5654571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS3 (Canis familiaris)
RHEA:63928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-5693356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEMIP hydrolyses HA (Danio rerio)
RHEA:68010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O
RHEA:42804	skos:prefLabel	"dihydromethanopterin reductase (acceptor)"
RHEA:42804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + A = 7,8-dihydromethanopterin + AH2
RHEA:42804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydromethanopterin reductase (acceptor)"
REACT:R-BTA-141409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mad1 binds kinetochore (Bos taurus)
EC:2.4.2.8	skos:altLabel	"IMP pyrophosphorylase"
EC:2.4.2.8	skos:prefLabel	"hypoxanthine phosphoribosyltransferase"
EC:2.4.2.8	skos:altLabel	"transphosphoribosidase"
EC:2.4.2.8	skos:altLabel	"guanine phosphoribosyltransferase"
EC:2.4.2.8	skos:altLabel	"hypoxanthine-guanine phosphoribosyltransferase"
EC:2.4.2.8	skos:altLabel	"HGPRTase"
EC:2.4.2.8	skos:altLabel	"IMP diphosphorylase"
EC:2.4.2.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hypoxanthine phosphoribosyltransferase"
RHEA:17468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + quercitrin <=> L-rhamnopyranose + quercetin
RHEA:40271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecanedioyl-CoA = (2E)-tetradecenedioyl-CoA + H2O2
GO:0018509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity
GO:0018509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity
GO:0018509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity
GO:0018509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity
RHEA:41877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydodecanoyl-[ACP] => (2E)-dodecenoyl-[ACP] + H2O
RHEA:72209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + 2 hydrogencarbonate(out) => chloride(out) + 2 hydrogencarbonate(in)
REACT:R-XTR-2179415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Xenopus tropicalis)
RHEA:33014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9031894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPAn-3 maresins translocate from cytosol to extracellular region (Homo sapiens)
GO:0015415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphate ion transmembrane-transporting ATPase activity
GO:0015415	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ABC phosphate transporter activity
GO:0015415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate porter activity
GO:0015415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate transporting ATPase activity
GO:0015415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP phosphohydrolase (phosphate-importing)
GO:0015415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphate-transporting ATPase activity
GO:0015415	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphate ABC transporter
GO:0015415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled phosphate ion transmembrane transporter activity
REACT:R-DME-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Drosophila melanogaster)
RHEA:28257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hex-3-en-1-ol + acetyl-CoA <=> (3Z)-hex-3-en-1-yl acetate + CoA
GO:0004805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose-6-phosphate phosphohydrolase activity
GO:0004805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose-phosphatase activity
GO:0004805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose 6-phosphatase activity
GO:0004805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose phosphatase activity
GO:0004805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose 6-phosphate phosphatase activity
RHEA:60218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2
REACT:R-HSA-2161979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH (Homo sapiens)
EC:1.20.99.-	skos:prefLabel	"With other acceptors"
EC:1.20.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
REACT:R-GGA-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Gallus gallus)
REACT:R-PFA-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Plasmodium falciparum)
REACT:R-HSA-212706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipase C-gamma1 binds to the activated EGF receptor (Homo sapiens)
RHEA:10569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-beta-D-glucuronide + UDP
REACT:R-MMU-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Mus musculus)
RHEA:10975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-hexose + H(+) + phosphoramidate <=> alpha-D-hexose 1-phosphate + NH4(+)
REACT:R-BTA-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Bos taurus)
REACT:R-BTA-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Bos taurus)
REACT:R-SSC-9018499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and EP300 are recruited to TFF3 promoter (Sus scrofa)
REACT:R-SPO-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Schizosaccharomyces pombe)
REACT:R-HSA-2018659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Homo sapiens)
REACT:R-GGA-5624129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LZTFL1 binds the BBSome and prevents its traffic to the cilium (Gallus gallus)
RHEA:48984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + glyoxylate + succinate
REACT:R-RNO-9036727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAA hydrolyzes lysosomal glycogen (Rattus norvegicus)
GO:0102253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity
REACT:R-CFA-5690827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 (Canis familiaris)
REACT:R-CFA-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Canis familiaris)
REACT:R-XTR-5683986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APBB1 and MAPK8 bind diphosphorylated H2AFX (Xenopus tropicalis)
REACT:R-GGA-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Gallus gallus)
RHEA:10222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr) => ATP + L-tyrosine + tRNA(Tyr)
REACT:R-HSA-428510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Homo sapiens)
RHEA:69834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-909732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT2 (Canis familiaris)
REACT:R-HSA-382055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb7 binds to the active PDGF receptor (Homo sapiens)
RHEA:33383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + UDP-N-acetyl-alpha-D-glucosamine = (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP
GO:0106075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide N-succinyltransferase activity
RHEA:12302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine + uridine(47) in tRNA(Phe)
REACT:R-HSA-193460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Homo sapiens)
REACT:R-XTR-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Xenopus tropicalis)
REACT:R-MMU-5218640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates p-Y397-PTK2 (Mus musculus)
REACT:R-HSA-5672843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)
REACT:R-BTA-8874201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L3 (Bos taurus)
REACT:R-DME-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Drosophila melanogaster)
REACT:R-HSA-167684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLCG1 dissociates from TrkA receptor (Homo sapiens)
REACT:R-RNO-9645406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Rattus norvegicus)
RHEA:23582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin I2 => prostaglandin H2
REACT:R-SCE-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Saccharomyces cerevisiae)
REACT:R-SPO-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Schizosaccharomyces pombe)
REACT:R-GGA-8985988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Gallus gallus)
RHEA:35118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + H(+) + malonyl-CoA <=> (4-coumaroyl)acetyl-CoA + CO2 + CoA
REACT:R-RNO-381543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP4 binds IGF forming IGF:IGFBP4 (Rattus norvegicus)
RHEA:39196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetracosanoyl-CoA + H(+) + NADPH => (3R)-hydroxytetracosanoyl-CoA + NADP(+)
REACT:R-RNO-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Rattus norvegicus)
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-2-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactoside 2-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-galactoside alpha1->2 fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha(1,2)-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-lactose fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-(1->2)-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactoside 2-alpha-L-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	secretor-type beta-galactoside alpha1->2 fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-fucose:lactose fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP fucose-lactose fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphospho-L-fucose-lactose fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-galactoside alpha-1->2 fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	blood group H alpha-2-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-2-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity
GO:0008107	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	blood-group substance H-dependent fucosyltransferase activity
RHEA:35806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 2'-phosphate + H(+)
REACT:R-SSC-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Sus scrofa)
REACT:R-DRE-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Danio rerio)
REACT:R-DDI-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Dictyostelium discoideum)
REACT:R-DME-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Drosophila melanogaster)
REACT:R-MMU-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
REACT:R-XTR-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Xenopus tropicalis)
RHEA:48615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]
REACT:R-HSA-9036729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GAA does not hydrolyze lysosomal glycogen (Homo sapiens)
REACT:R-RNO-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Rattus norvegicus)
REACT:R-XTR-392263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR2 (Xenopus tropicalis)
REACT:R-DDI-450971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Dictyostelium discoideum)
REACT:R-RNO-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Rattus norvegicus)
REACT:R-SSC-8875568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 activates RAP1 (Sus scrofa)
REACT:R-CEL-157849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes containing mRNA that does not circularize (Caenorhabditis elegans)
RHEA:56017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)
RHEA:34873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol(in) => methanol(out)
REACT:R-DME-8855648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM3 binds LAR-RPTP (Drosophila melanogaster)
RHEA:31043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonate semialdehyde + H2O + NAD(+) = 2 H(+) + methylmalonate + NADH
REACT:R-HSA-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Homo sapiens)
RHEA:64381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + phytyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2
REACT:R-SSC-114252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-3 by the apoptosome (Sus scrofa)
REACT:R-MMU-9700662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Mus musculus)
REACT:R-MMU-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Mus musculus)
REACT:R-CEL-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)
REACT:R-SSC-350604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Agmatine + H2O <=> putrescine + urea (Sus scrofa)
REACT:R-HSA-9615721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8 binds substrate (Homo sapiens)
REACT:R-HSA-2161789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15S-HETE is oxidised to 15-oxoETE by 15-HEDH (Homo sapiens)
RHEA:65235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydodecanoyl-CoA + H2O <=> 3-hydroxydodecanoate + CoA + H(+)
REACT:R-RNO-5205681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is cleaved on healthy mitochondria (Rattus norvegicus)
REACT:R-CEL-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Caenorhabditis elegans)
REACT:R-GGA-265951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of FANCG at S7 (Gallus gallus)
REACT:R-HSA-5623558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol (Homo sapiens)
REACT:R-CEL-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Caenorhabditis elegans)
RHEA:30579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-threonine = L-threonine + phosphate
RHEA:23919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + UDP-alpha-D-glucuronate <=> CO2 + UDP-alpha-D-xylose
GO:0052848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
RHEA:55255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-GGA-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Gallus gallus)
RHEA:38359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 = thiosulfate + ubiquinol-10
REACT:R-XTR-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Xenopus tropicalis)
REACT:R-HSA-1912396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 binds HIF1A (Homo sapiens)
RHEA:58590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-vincadifformine + acetate + NADP(+) => dihydroprecondylocarpine acetate + NADPH
RHEA:27648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-phosphate + hypoxanthine => inosine + phosphate
REACT:R-BTA-193393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Bos taurus)
REACT:R-RNO-6814683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Rattus norvegicus)
REACT:R-XTR-176517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to PREG (Xenopus tropicalis)
EC:1.14.14.16	skos:altLabel	"steroid 21-hydroxylase"
EC:1.14.14.16	skos:altLabel	"cytochrome p450 XXIA1"
EC:1.14.14.16	skos:prefLabel	"steroid 21-monooxygenase"
EC:1.14.14.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steroid 21-monooxygenase"
EC:1.14.14.16	skos:altLabel	"CYP21A2"
GO:0120274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	virus coreceptor activity
GO:0120274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viral coreceptor activity
RHEA:16028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA <=> an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA
REACT:R-RNO-114697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Rattus norvegicus)
REACT:R-SCE-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Saccharomyces cerevisiae)
REACT:R-DRE-913424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SHC1:SHIP1 complex is stabilized by GRB2 (Danio rerio)
REACT:R-HSA-977629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of C2a/Bb by CR1 (Homo sapiens)
REACT:R-BTA-77274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Bos taurus)
REACT:R-DRE-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Danio rerio)
REACT:R-HSA-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)
REACT:R-SPO-379387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DA to form 3MT (Schizosaccharomyces pombe)
REACT:R-RNO-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Rattus norvegicus)
REACT:R-DRE-212356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL-NICD coactivator complex (Danio rerio)
REACT:R-CEL-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)
REACT:R-HSA-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Homo sapiens)
REACT:R-DRE-6805640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates KAT6A (Danio rerio)
REACT:R-BTA-5654408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS2 (Bos taurus)
RHEA:59962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha)-acetyl-L-methionine => N(alpha)-acetyl-D-methionine
RHEA:65836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate
REACT:R-BTA-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Bos taurus)
RHEA:72054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) + estrone 3-sulfate(in) <=> butanoate(in) + estrone 3-sulfate(out)
REACT:R-RNO-1483096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA is dephosphorylated to ETA by PHOSPHO1 (Rattus norvegicus)
RHEA:69244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate = 5-methylsulfinylpentyl nitrile + sulfate + sulfur
RHEA:69463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine <=> [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine
RHEA:70939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) = L-methionine(out)
REACT:R-SSC-201521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK autophosphorylation downstream of PTN and MDK (Sus scrofa)
REACT:R-HSA-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Homo sapiens)
RHEA:61150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP => myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose
REACT:R-DRE-5687653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Danio rerio)
RHEA:44782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-9 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-9 + S-adenosyl-L-methionine
RHEA:65018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxychlorothalonil + chloride + 2 H(+) => chlorothalonil + H2O
RHEA:28349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate <=> 7,8-dihydromonapterin 3'-triphosphate
REACT:R-SSC-5693608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial resection of double-strand break ends (Sus scrofa)
RHEA:47806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DDI-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Dictyostelium discoideum)
RHEA:47908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O = 6-deoxy-6-sulfo-D-gluconate + H(+)
RHEA:47908	skos:altLabel	"SGL lactonase"
RHEA:47908	skos:prefLabel	"6-deoxy-6-sulfogluconolactonase"
RHEA:47908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-deoxy-6-sulfogluconolactonase"
REACT:R-XTR-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Xenopus tropicalis)
REACT:R-DRE-1655851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2P hydrolyzes SREBP1A,1C,2 (Danio rerio)
RHEA:51306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate
REACT:R-GGA-8940998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36RN, IL1F10 bind IL1RL2 (Gallus gallus)
RHEA:17508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(long-chain fatty acyl)ethanolamine <=> a long-chain fatty acid + ethanolamine
RHEA:66839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]
RHEA:66741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate
REACT:R-DRE-8874470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Danio rerio)
RHEA:41523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-388829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 phosphatase binds CTLA-4 (Canis familiaris)
GO:0052924	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	solanesyl diphosphate synthetase activity
GO:0052924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity
GO:0052924	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nonaprenyl diphosphate synthase activity
GO:0052924	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	solanesyl diphosphate synthase activity
REACT:R-BTA-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)
REACT:R-MMU-947673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanin-concentrating hormone receptors bind MCH (Mus musculus)
REACT:R-CEL-8854759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D14 binds RAB11 and ULK1 (Caenorhabditis elegans)
GO:0018785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monohaloacetate dehalogenase activity
GO:0018785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	haloacetate halidohydrolase activity
GO:0018785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	haloacetate dehalogenase activity
RHEA:72731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose(in) + UMP(out) = UDP-alpha-D-glucose(out) + UMP(in)
REACT:R-SSC-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)
REACT:R-HSA-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Homo sapiens)
REACT:R-GGA-3827958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by MMP9, KLK7 (Gallus gallus)
REACT:R-RNO-8854462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds VLDL (Rattus norvegicus)
REACT:R-HSA-177941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:GAB1 binds to phosphorylated EGFR (Homo sapiens)
REACT:R-DRE-3149563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Danio rerio)
REACT:R-DME-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Drosophila melanogaster)
RHEA:64792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NADP(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)
REACT:R-CFA-201472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Canis familiaris)
REACT:R-SSC-975122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Sus scrofa)
REACT:R-XTR-5691411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Xenopus tropicalis)
REACT:R-XTR-5617815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binds RAB3IP (Xenopus tropicalis)
RHEA:52789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a + 2 H(+) => Mg(2+) + pheophytin a
REACT:R-CEL-209840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two DITs combine to form thyroxine (Caenorhabditis elegans)
REACT:R-DRE-4093336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)
RHEA:43368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:10152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O
RHEA:10152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carbamate kinase"
RHEA:10152	skos:prefLabel	"carbamate kinase"
REACT:R-BTA-5607733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 binds CARD9 (Bos taurus)
RHEA:59066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteothin + S-adenosyl-L-homocysteine => demethylluteothin + S-adenosyl-L-methionine
RHEA:67166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'-bromomelleolide F + FAD + 2 H2O => bromide + FADH2 + melleolide F + O2
RHEA:61742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + steviolbioside + UDP => steviolmonoside + UDP-alpha-D-glucose
GO:0102374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ursolic aldehyde 28-monooxygenase activity
REACT:R-GGA-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Gallus gallus)
REACT:R-HSA-6803240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)
REACT:R-HSA-9673346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates p-DVL (Homo sapiens)
REACT:R-HSA-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Homo sapiens)
REACT:R-HSA-9023617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrylcholinesterase hydrolyzes acyl Ghrelin (Homo sapiens)
RHEA:67822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-GGA-190413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2c (Gallus gallus)
REACT:R-MMU-5624129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LZTFL1 binds the BBSome and prevents its traffic to the cilium (Mus musculus)
REACT:R-XTR-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Xenopus tropicalis)
GO:0004991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	parathyroid hormone receptor activity
REACT:R-SSC-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)
REACT:R-GGA-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Gallus gallus)
RHEA:40216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + O2 => FAD + H(+) + H2O2
GO:0016521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pituitary adenylate cyclase activating polypeptide activity
GO:0016521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pituitary adenylyl cyclase activating polypeptide activity
REACT:R-BTA-3132753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pancreatic proteases degrade TCN1:RCbl (Bos taurus)
GO:0110152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA NAD-cap (NAD-forming) hydrolase activity
GO:0110152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)
REACT:R-SPO-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Schizosaccharomyces pombe)
RHEA:48842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2
REACT:R-MMU-5660666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBP and p300 binds NF-kB complex (Mus musculus)
REACT:R-DME-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Drosophila melanogaster)
REACT:R-GGA-9667569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,2 bind AVPR antagonists (Gallus gallus)
REACT:R-GGA-2132247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD59 binds C5b:C6:C7:C8 (Gallus gallus)
RHEA:61765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside E + UDP
REACT:R-DRE-74740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SHC1 to insulin receptor (Danio rerio)
REACT:R-HSA-5357757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
REACT:R-XTR-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Xenopus tropicalis)
REACT:R-BTA-2294590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds phosphorylated condensin II complex (Bos taurus)
REACT:R-BTA-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Bos taurus)
REACT:R-BTA-430347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MigFilin associates with Filamin and F-actin (Bos taurus)
RHEA:71492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)
RHEA:20367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine => phosphoethanolamine + S-adenosyl-L-methionine
RHEA:28315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baicalein + UDP-alpha-D-glucuronate => baicalin + UDP
REACT:R-HSA-192178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)
RHEA:63986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine 5'-phosphate + ADP + H(+) => 5-hydroxyuridine + ATP
REACT:R-BTA-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Bos taurus)
RHEA:27284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+) => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O
RHEA:38957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine 1-phosphate(out) => an N-acylsphing-4-enine 1-phosphate(in)
REACT:R-HSA-1606839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Steryl sulfatase hydrolyses sulfate from steroid sulfates (Homo sapiens)
REACT:R-BTA-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Bos taurus)
RHEA:42624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-ureidoacrylate + H(+) + H2O = (Z)-3-aminoacrylate + CO2 + NH4(+)
RHEA:70068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)
RHEA:29325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(out) + succinate(in) => fumarate(in) + succinate(out)
GO:0036355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminoacetate synthase activity
REACT:R-DME-429441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK activation by SRC (Drosophila melanogaster)
RHEA:26347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galacturonate + H(+) + NADPH => L-galactonate + NADP(+)
RHEA:67387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-8855131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9 binds Clathrin-coated vesicles (Sus scrofa)
REACT:R-CFA-5668467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTNFR2 binds TNFA trimer:TNFR2 (Canis familiaris)
RHEA:33566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + ATP <=> (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)
GO:0046872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal binding
GO:0046872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal ion binding
GO:0046872	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heavy metal binding
REACT:R-SSC-996755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFPM proteins bind GATA proteins (Sus scrofa)
RHEA:27761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)
REACT:R-SCE-1482545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)
RHEA:19623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 3'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O
GO:0042922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuromedin U receptor binding
REACT:R-RNO-443831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3-zeta binds Raf1 (Rattus norvegicus)
REACT:R-SSC-2022065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPGs are secreted (Sus scrofa)
RHEA:64177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-tryptophan => (9Z)-octadecenoate + L-tryptophan
REACT:R-DRE-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Danio rerio)
REACT:R-SSC-3928595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ARP2/3 and G-actin (Sus scrofa)
REACT:R-RNO-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Rattus norvegicus)
REACT:R-SSC-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Sus scrofa)
RHEA:46627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-5-monosubstituted hydantoin <=> a L-5-monosubstituted hydantoin
RHEA:40684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol => 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-CFA-198813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO dimers reduce DeHA to AscH- (Canis familiaris)
REACT:R-SCE-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Saccharomyces cerevisiae)
REACT:R-HSA-5606996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds activated protein C (Homo sapiens)
REACT:R-RNO-379382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates DA to DOPAC (Rattus norvegicus)
REACT:R-CFA-174174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Canis familiaris)
RHEA:59016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) = CO2 + cycloeucalenone + NADH
RHEA:36062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydrourocanate <=> AH2 + urocanate
RHEA:19738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanoate + H2O => 4-aminobutanoate + L-glutamate
RHEA:66356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) = (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH
RHEA:10042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + phosphate => adenosine 3',5'-bisphosphate + H2O
REACT:R-XTR-4755411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates IKBKG with SUMO1 (Xenopus tropicalis)
RHEA:66730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in)
REACT:R-MMU-5578965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A binds AGO2:miRNA (Mus musculus)
REACT:R-SSC-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Sus scrofa)
REACT:R-DRE-388560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA,EDNRB bind EDNs (Danio rerio)
RHEA:11408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + riboflavin = lumichrome + ribitol
RHEA:11408	skos:prefLabel	"riboflavinase"
RHEA:11408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"riboflavinase"
REACT:R-BTA-5696838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Bos taurus)
RHEA:66313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-mannosylinositol-1-phosphoceramide + H2O => a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)
RHEA:31965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:19944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norcoclaurine + S-adenosyl-L-methionine <=> coclaurine + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Gallus gallus)
REACT:R-CEL-189062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + H2O => D-glucose + D-galactose (Caenorhabditis elegans)
RHEA:34004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 => 7-dehydrodesmosterol + 2 H2O + NADP(+)
REACT:R-RNO-5654667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
RHEA:10322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline-2-carboxylate + H2O => trans-3-hydroxy-L-proline
RHEA:43142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(26) in tRNA + 2 S-adenosyl-L-methionine
REACT:R-BTA-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Bos taurus)
REACT:R-HSA-449200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ABL1 with CDO complex (Homo sapiens)
GO:0019171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyacyl-ACP dehydratase activity
GO:0019171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyacyl-[acyl-carrier protein] dehydratase activity
GO:0019171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
REACT:R-CFA-2168885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin binds Hemoglobin (Canis familiaris)
REACT:R-SSC-5691381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYSM1 deubiquitinates Histone H2A (Sus scrofa)
RHEA:67360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-threonyl-L-threonine = 2 L-threonine
REACT:R-BTA-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Bos taurus)
RHEA:37783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-XTR-1297333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Acrosin Heavy and Light Chain (Xenopus tropicalis)
REACT:R-CFA-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Canis familiaris)
REACT:R-BTA-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Bos taurus)
REACT:R-GGA-71050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of the FASL:FAS receptor complex (Gallus gallus)
REACT:R-CEL-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Caenorhabditis elegans)
GO:0015362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity sodium:dicarboxylate symporter activity
GO:0015362	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	high affinity sodium:dicarboxylate cotransporter activity
GO:0015362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity sodium:dicarboxylate symporter activity
GO:0015362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Homo sapiens)
REACT:R-HSA-844438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 oligomerizes (Homo sapiens)
REACT:R-CEL-2161195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Caenorhabditis elegans)
RHEA:12769	skos:prefLabel	"gluconate 2-dehydrogenase (acceptor)"
RHEA:12769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gluconate 2-dehydrogenase (acceptor)"
RHEA:12769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-gluconate = 2-dehydro-D-gluconate + AH2
GO:0019181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	halohydrin hydrogen-halide-lyase activity
RHEA:44885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)
GO:0022836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gated channel activity
RHEA:24332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-3,5-dihydromonacolin L carboxylate = H2O + monacolin L carboxylate
REACT:R-SSC-983138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC heterotrimer to ER exit site (Sus scrofa)
RHEA:10927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide
REACT:R-MMU-71335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Mus musculus)
REACT:R-BTA-8939323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 binds BCL10 and Ubiquitin:E2 (Bos taurus)
RHEA:58914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + iron(III) dicitrate(in) + phosphate => ATP + H2O + iron(III) dicitrate(out)
REACT:R-DRE-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Danio rerio)
RHEA:48139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + H2O <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate
REACT:R-DDI-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Dictyostelium discoideum)
RHEA:70676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Met-enkephalin-Arg-Phe => L-arginyl-L-phenylalanine + Met-enkephalin
RHEA:46890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2 => 3-deoxy-alpha-D-manno-oct-2-ulosonate + O2
REACT:R-XTR-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Xenopus tropicalis)
RHEA:33668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)
RHEA:71290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-arginine(out) + 2 Na(+)(out) <=> chloride(in) + L-arginine(in) + 2 Na(+)(in)
REACT:R-DRE-202726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F11R dimerises (Danio rerio)
RHEA:29507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-alpha-gurjunene + diphosphate
RHEA:29507	skos:prefLabel	"alpha-gurjunene synthase"
RHEA:29507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-gurjunene synthase"
REACT:R-SCE-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Saccharomyces cerevisiae)
REACT:R-DRE-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Danio rerio)
GO:0047148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylamine:L-glutamate N-methyltransferase activity
GO:0047148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methylglutamate synthase activity
GO:0047148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylamine-glutamate methyltransferase activity
GO:0047148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylamine-glutamate N-methyltransferase activity
REACT:R-CFA-9033949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Canis familiaris)
RHEA:60872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP
REACT:R-BTA-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Bos taurus)
RHEA:70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:35759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6806674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Homo sapiens)
REACT:R-BTA-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Bos taurus)
RHEA:41160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)
RHEA:47188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol = hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]
RHEA:51634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:40193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanoyl-CoA + H(+) + NADH => (3R)-hydroxyoctanoyl-CoA + NAD(+)
REACT:R-DDI-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Dictyostelium discoideum)
RHEA:63463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + GTP <=> (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)
REACT:R-GGA-420592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectin-like (Necl) proteins (Gallus gallus)
RHEA:29971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine(in) + H(+)(in) = 2'-deoxyinosine(out) + H(+)(out)
GO:0047475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PA-CoA ligase activity
GO:0047475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenacyl coenzyme A synthetase activity
GO:0047475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylacetate:CoA ligase (AMP-forming)
GO:0047475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetate-CoA ligase activity
GO:0047475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylacetyl-CoA ligase (AMP-forming)
GO:0047475	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylacetyl-CoA ligase activity
REACT:R-MMU-388817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICOS binds ICOSL/B7-H2 (Mus musculus)
REACT:R-BTA-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Bos taurus)
REACT:R-HSA-6790041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of STAT3-upregulated cytosolic proteins (Homo sapiens)
RHEA:53358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NADP(+)
RHEA:33745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + phosphate => an N-acylsphing-4-enine 1-phosphate + H2O
RHEA:31262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	but-3-ynal + H2O + NAD(+) <=> 3-butynoate + 2 H(+) + NADH
RHEA:25469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => beta-himachalene + diphosphate
RHEA:32968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine
GO:0018112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline racemase activity
REACT:R-SSC-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Sus scrofa)
RHEA:47572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) = CMP + ganglioside GT1b (d18:1(4E)) + H(+)
REACT:R-XTR-934559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is phosphorylated by phosphorylated MNK1 (Xenopus tropicalis)
REACT:R-MMU-8854044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Mus musculus)
REACT:R-SPO-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Schizosaccharomyces pombe)
REACT:R-BTA-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)
RHEA:18306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-4-O-acetylneuraminate
RHEA:60928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5624954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INPP5E translocates to the primary cilium (Bos taurus)
REACT:R-SCE-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Saccharomyces cerevisiae)
REACT:R-MMU-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Mus musculus)
RHEA:62344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate = diphosphate + notoamide S
RHEA:47147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:11563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> catechol + CO2 + NADH
REACT:R-CEL-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Caenorhabditis elegans)
REACT:R-BTA-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Bos taurus)
RHEA:21377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + O2 => (S)-4-hydroxymandelate + CO2
RHEA:51102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0034861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on carbon-sulfur bonds"
GO:0034861	skos:prefLabel	"Acting on carbon-sulfur bonds"
GO:0034861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzothiazole-2-sulfonate hydrolase activity
REACT:R-DRE-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Danio rerio)
REACT:R-CFA-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
RHEA:37746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl phosphate + FMNH2 <=> phosphate + prenyl-FMNH2
RHEA:34277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine => 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine
REACT:R-SSC-9020264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Sus scrofa)
RHEA:36965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA
RHEA:33251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 sucrose = 6-kestotriose + beta-D-glucose
REACT:R-HSA-6804229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMY, TTC5 and EP300 bind (Homo sapiens)
RHEA:14574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate => 5-dehydro-4-deoxy-D-glucarate + H2O
RHEA:28941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + xanthosine(out) => H(+)(in) + xanthosine(in)
GO:0103009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chlorotoluene monooxygenase activity
REACT:R-HSA-114558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate Gq (Homo sapiens)
GO:0031927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine transmembrane transporter activity
RHEA:24071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanone + H(+) + NADPH + O2 <=> H2O + hexano-6-lactone + NADP(+)
REACT:R-XTR-73813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAR + 10-Formyl-THF => FGAR + THF (Xenopus tropicalis)
REACT:R-MMU-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Mus musculus)
REACT:R-CFA-9706399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 hydrolyzes ATP (Canis familiaris)
REACT:R-SSC-8963851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 dissociates from GC (Sus scrofa)
REACT:R-HSA-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Homo sapiens)
RHEA:40695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol = 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-HSA-1222690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DlaT reactivates AhpD (Homo sapiens)
REACT:R-GGA-433606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Gallus gallus)
RHEA:59242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoarginine + L-ornithine => L-arginine + L-lysine
RHEA:64195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-lysine <=> (9Z)-octadecenoate + L-lysine
RHEA:60737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesal + H2O + NADP(+) => (2E,6E)-farnesoate + 2 H(+) + NADPH
REACT:R-DRE-1168633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB translocates from the cytosol to the nucleus (Danio rerio)
RHEA:32868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol(out) => myo-inositol(in)
REACT:R-GGA-3322429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP monoubiquinates TLE (Gallus gallus)
RHEA:66594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) => 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA
REACT:R-CFA-211247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DNA by DFF40 (Canis familiaris)
RHEA:68324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,5-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate
REACT:R-GGA-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Gallus gallus)
RHEA:46813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-BTA-879914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3 stimulation induces Vav binding to Tec kinase (Bos taurus)
RHEA:29469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + K(+)(out) => H(+)(out) + K(+)(in)
REACT:R-SSC-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Sus scrofa)
REACT:R-BTA-71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Bos taurus)
REACT:R-SSC-201453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 dissociates from the receptor complex (Sus scrofa)
RHEA:36959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribono-1,4-lactone + H(+) + NADH = D-ribose + NAD(+)
REACT:R-DRE-9649108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer binds 5HT (Danio rerio)
RHEA:22589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal => 1-pyrroline + H2O
REACT:R-RNO-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
REACT:R-RNO-2395876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
REACT:R-SPO-450550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCalpha phosphorylates HuR (Schizosaccharomyces pombe)
REACT:R-SPO-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Schizosaccharomyces pombe)
GO:0047602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetate carboxy-lyase activity
GO:0047602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetate carboxy-lyase (acetone-forming)
GO:0047602	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetic acid decarboxylase activity
GO:0047602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate decarboxylase activity
RHEA:48733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O => [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine
RHEA:28679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-8 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-8
RHEA:32994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-BTA-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Bos taurus)
REACT:R-BTA-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Bos taurus)
REACT:R-RNO-449073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-3 cleaves pro-interleukin-16 (Rattus norvegicus)
RHEA:65349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA => 3-oxochol-4,6-dien-24-oyl-CoA + H2O
RHEA:61728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-dehydro-D-guloside = a 3-dehydro-D-glucoside
RHEA:45094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanoate + sphing-4-enine => H2O + N-octanoylsphing-4-enine
REACT:R-MMU-383373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 3 (NK3) binds to neurokinin B (Mus musculus)
REACT:R-HSA-420489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)
REACT:R-HSA-5658496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIAH1:UBE2L6:Ubiquitin binds SNCA (Homo sapiens)
RHEA:61305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose => H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP
REACT:R-RNO-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Rattus norvegicus)
REACT:R-SSC-8857583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by PTK6 (Sus scrofa)
REACT:R-SSC-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Sus scrofa)
RHEA:35465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-7-en-3-one + H(+) + NADH => lathosterol + NAD(+)
RHEA:56931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ochratoxin A = L-phenylalanine + ochratoxin alpha
REACT:R-HSA-442368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
GO:0001016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase III regulatory region DNA binding
GO:0001016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III transcription regulatory region sequence-specific DNA binding
RHEA:28703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(in) = Cu(2+)(out)
EC:1.14.13.218	skos:prefLabel	"5-methylphenazine-1-carboxylate 1-monooxygenase"
EC:1.14.13.218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-methylphenazine-1-carboxylate 1-monooxygenase"
GO:0000979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II core promoter sequence-specific DNA binding
REACT:R-SSC-6799203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Sus scrofa)
REACT:R-CFA-109699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
RHEA:27398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-demethylrebeccamycin + H2O => beta-D-glucose + dichloroarcyriaflavin A
REACT:R-DRE-4084989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Danio rerio)
REACT:R-GGA-8951951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds EP300 (Gallus gallus)
RHEA:19627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + glycine => L-threonine
RHEA:49756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O2 + protoviolaceinate = CO2 + H2O + proviolacein
RHEA:23304	skos:altLabel	"Atropine acylhydrolase"
RHEA:23304	skos:altLabel	"Atropinesterase"
RHEA:23304	skos:prefLabel	"tropinesterase"
RHEA:23304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atropine + H2O = H(+) + tropate + tropine
RHEA:23304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tropinesterase"
RHEA:40255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenedioyl-CoA + H2O = (3R)-hydroxyhexadecanedioyl-CoA
RHEA:22818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xylulofuranose => alpha-D-xylose
RHEA:49097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine
REACT:R-XTR-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Xenopus tropicalis)
REACT:R-MMU-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Mus musculus)
REACT:R-SCE-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Saccharomyces cerevisiae)
REACT:R-XTR-5618328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAT acetylates microtubules (Xenopus tropicalis)
RHEA:46007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanal + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + H(+) + NADH
REACT:R-CFA-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Canis familiaris)
RHEA:38101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + phytyl diphosphate => a ribonucleoside 5'-triphosphate + phytyl phosphate
REACT:R-CEL-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Caenorhabditis elegans)
REACT:R-MMU-193452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Mus musculus)
RHEA:66326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide(in) => iodide(out)
REACT:R-RNO-8954082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds the PRC1 complex (Rattus norvegicus)
REACT:R-XTR-6794347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 dimerizes (Xenopus tropicalis)
RHEA:59266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O
RHEA:39295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O
RHEA:24961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 => [excited state blue fluorescent protein] + CO2
REACT:R-MMU-9707504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 oxidises ferrohemoglobin to MetHb (Mus musculus)
REACT:R-BTA-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Bos taurus)
REACT:R-RNO-2328033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds latent TGF-beta (Rattus norvegicus)
REACT:R-CEL-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Caenorhabditis elegans)
REACT:R-RNO-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Rattus norvegicus)
REACT:R-RNO-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Rattus norvegicus)
REACT:R-MMU-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Mus musculus)
REACT:R-SSC-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Sus scrofa)
REACT:R-HSA-1614605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is dioxygenated (Homo sapiens)
REACT:R-XTR-382052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130Cas and C3G bind PDGFR bound Crk (Xenopus tropicalis)
REACT:R-CFA-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Canis familiaris)
REACT:R-DME-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Drosophila melanogaster)
GO:0071837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG box domain binding
REACT:R-BTA-6783524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM,LIF,CTF1 receptor complex binds gp130 (Bos taurus)
REACT:R-RNO-8852167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:Catecholamine binds ARRB1, ARRB2 (Rattus norvegicus)
REACT:R-RNO-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Rattus norvegicus)
REACT:R-XTR-8878220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the NOTCH1 coactivator complex (Xenopus tropicalis)
RHEA:27483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-5357432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL binds SRC-1 (Homo sapiens)
REACT:R-BTA-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Bos taurus)
REACT:R-GGA-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)
REACT:R-XTR-9605609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Xenopus tropicalis)
REACT:R-BTA-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Bos taurus)
RHEA:70591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:56005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)
RHEA:50582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein]
REACT:R-HSA-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)
REACT:R-SPO-2993780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO1 from E1 to UBE2I (UBC9) (Schizosaccharomyces pombe)
RHEA:49504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphinomethylmalate = phosphinomethylisomalate
RHEA:49504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphinomethylmalate isomerase"
RHEA:49504	skos:prefLabel	"phosphinomethylmalate isomerase"
EC:1.1.3.29	skos:prefLabel	"N-acylhexosamine oxidase"
EC:1.1.3.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acylhexosamine oxidase"
RHEA:42276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA
REACT:R-HSA-1810457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZBP1(DAI) recruits RIP1 and RIP3 (Homo sapiens)
REACT:R-SSC-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Sus scrofa)
REACT:R-HSA-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Homo sapiens)
RHEA:21458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-6804998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)
REACT:R-RNO-2393954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)
REACT:R-DRE-72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of eIF4E from the inactive eIF4E:4E-BP complex  (Danio rerio)
REACT:R-XTR-445071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reinsertion of L1 into the plasma membrane (Xenopus tropicalis)
REACT:R-DME-71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Drosophila melanogaster)
REACT:R-DRE-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Danio rerio)
GO:0052789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-1,3-mannase activity
GO:0052789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,3-beta-mannanase activity
GO:0052789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannan 1,3-beta-mannosidase activity
GO:0052789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-mannan mannanohydrolase activity
GO:0052789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,3-mannanase activity
GO:0052789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,3-mannan 3-mannanohydrolase activity
RHEA:60485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + UTP => cyclic CMP-UMP + 2 diphosphate
REACT:R-XTR-109387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Xenopus tropicalis)
REACT:R-DRE-70679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 oxidises L-GluSS to Glu (Danio rerio)
REACT:R-HSA-166817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by C3 convertases (Homo sapiens)
REACT:R-CEL-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)
REACT:R-CEL-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Caenorhabditis elegans)
REACT:R-RNO-4420206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SRC-1 (Rattus norvegicus)
EC:1.4.1.26	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-diaminopentanoate dehydrogenase (NAD(+))"
EC:1.4.1.26	skos:altLabel	"DAPDH"
EC:1.4.1.26	skos:prefLabel	"2,4-diaminopentanoate dehydrogenase (NAD(+))"
RHEA:24836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate
RHEA:24836	skos:altLabel	"5-formaminoimidazole-4-carboxamide ribonucleotide synthetase"
RHEA:24836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate--phosphoribosylaminoimidazolecarboxamide ligase"
RHEA:24836	skos:altLabel	"5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase"
RHEA:24836	skos:prefLabel	"formate--phosphoribosylaminoimidazolecarboxamide ligase"
RHEA:72574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) <=> dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)
RHEA:26029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal + H2O2 + N-acetylputrescine => H2O + N(1)-acetylspermidine + O2
REACT:R-SSC-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Sus scrofa)
REACT:R-SSC-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Sus scrofa)
REACT:R-MMU-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Mus musculus)
GO:0016895	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	exonuclease VIII activity
GO:0016895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exodeoxyribonuclease activity, producing 5' phosphomonoesters
GO:0016895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exodeoxyribonuclease activity, producing 5'-phosphomonoesters
REACT:R-SSC-8862137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B2 oxidises estradiol (E2) to estrone (E1) (Sus scrofa)
RHEA:43206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine
REACT:R-CEL-9647977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT methylates S-Farn RAS proteins (Caenorhabditis elegans)
REACT:R-RNO-5696021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPGK:Mg2+ phosphorylates Glc to G6P (Rattus norvegicus)
REACT:R-DME-8854051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)
REACT:R-GGA-2132233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic cleavage of complement factor C4 (Gallus gallus)
REACT:R-GGA-5577237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNH2:KCNE transport K+ from cytosol to extracellular region (Gallus gallus)
REACT:R-DME-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Drosophila melanogaster)
REACT:R-MMU-8853734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Mus musculus)
RHEA:14971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate
REACT:R-XTR-1602454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proMMP9 binds TIMP1 (Xenopus tropicalis)
RHEA:28266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-beta-bisabolene synthase"
RHEA:28266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate
RHEA:28266	skos:prefLabel	"(S)-beta-bisabolene synthase"
REACT:R-GGA-5368596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Gallus gallus)
RHEA:62106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine
RHEA:24062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:52457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone + UDP-alpha-D-glucuronate => H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP
REACT:R-HSA-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)
REACT:R-SSC-5624952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the retrograde IFT train (Sus scrofa)
REACT:R-BTA-443402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)
REACT:R-MMU-9700168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates IRS1 (Mus musculus)
REACT:R-RNO-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Rattus norvegicus)
REACT:R-DME-392752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by CK-II (Drosophila melanogaster)
RHEA:10482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxoglutarate + L-glutamate => 2-oxoglutarate + 4-hydroxy-L-glutamate
RHEA:72928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV
RHEA:44694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acylhexadecasphinganine => a fatty acyl-CoA + hexadecasphinganine
RHEA:42822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NADP(+) + tetracenomycin C => 2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2
REACT:R-SSC-9708517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Sus scrofa)
REACT:R-HSA-171026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine nucleotide exchange on RAL (Homo sapiens)
REACT:R-DDI-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Dictyostelium discoideum)
RHEA:50250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + diphosphate => ATP + D-ribose 5-phosphate + H(+)
REACT:R-BTA-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Bos taurus)
REACT:R-MMU-977602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to MCP, CR1:C4b, C3b (Mus musculus)
REACT:R-SSC-422021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Sus scrofa)
RHEA:16116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) <=> 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH
REACT:R-CFA-170978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-FRS2:CRKL binds C3G (Canis familiaris)
RHEA:11283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP
RHEA:47757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:64809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + O-(2-aminoethyl)-L-serine => CoA + H(+) + O-(2-acetamidoethyl)-L-serine
RHEA:48649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-194642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Sus scrofa)
REACT:R-XTR-5696230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO1 dimer reduces methylarsonate to methylarsonite (Xenopus tropicalis)
RHEA:42069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH => clavulanate + NADP(+)
REACT:R-DME-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Drosophila melanogaster)
REACT:R-GGA-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Gallus gallus)
RHEA:49478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-2-aminoadipate + NADH => 2 H2O + L-1-piperideine-6-carboxylate + NAD(+)
REACT:R-SSC-2201341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TRAM (TICAM2) (Sus scrofa)
REACT:R-BTA-6800798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome binds CASP2 (Bos taurus)
REACT:R-SSC-9009308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 polyubiquitinates RUNX2 (Sus scrofa)
REACT:R-HSA-9670149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TERRA transcription (Homo sapiens)
REACT:R-SSC-9014294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the plasma membrane (Sus scrofa)
REACT:R-SCE-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Saccharomyces cerevisiae)
REACT:R-SPO-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Schizosaccharomyces pombe)
EC:3.4.22.61	skos:altLabel	"FADD-like ICE"
EC:3.4.22.61	skos:altLabel	"ICE-like apoptotic protease 5"
EC:3.4.22.61	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-8"
EC:3.4.22.61	skos:altLabel	"apoptotic protease Mch-5"
EC:3.4.22.61	skos:altLabel	"FADD-homologous ICE/CED-3-like protease"
EC:3.4.22.61	skos:prefLabel	"caspase-8"
EC:3.4.22.61	skos:altLabel	"MACH"
EC:3.4.22.61	skos:altLabel	"apoptotic cysteine protease"
EC:3.4.22.61	skos:altLabel	"CASP-8"
EC:3.4.22.61	skos:altLabel	"MORT1-associated CED-3 homolog"
EC:3.4.22.61	skos:altLabel	"CAP4"
EC:3.4.22.61	skos:altLabel	"Mch5"
EC:3.4.22.61	skos:altLabel	"FLICE"
EC:3.4.22.61	skos:altLabel	"mammalian Ced-3 homolog 5"
RHEA:43502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucaro-1,5-lactone + H(+) + NADH => beta-D-glucuronate + NAD(+)
REACT:R-BTA-8964634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Bos taurus)
GO:0015106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bicarbonate transmembrane transporter activity
REACT:R-SSC-209924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is decarboxylated to dopamine (Sus scrofa)
REACT:R-HSA-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Homo sapiens)
REACT:R-BTA-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Bos taurus)
REACT:R-HSA-2161673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is dehydrated to 15d-PGD2 (Homo sapiens)
REACT:R-HSA-5218841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
GO:0016717	skos:prefLabel	"With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"
GO:0016717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0016717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"
REACT:R-RNO-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Rattus norvegicus)
REACT:R-DDI-70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate + H2O => 4-imidazolone-5-propionate (Dictyostelium discoideum)
REACT:R-PFA-5637686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)
RHEA:64233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + holo-[ACP] + 8 malonyl-CoA => atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O
RHEA:57962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfide + H(+) + NADH + O2
REACT:R-SSC-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Sus scrofa)
RHEA:57509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + staphylopine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate
RHEA:39927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-DRE-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Danio rerio)
GO:0030507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spectrin binding
REACT:R-SSC-266012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTD4 is converted to LTE4 by DPEP1/2 (Sus scrofa)
REACT:R-BTA-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Bos taurus)
REACT:R-CEL-8951850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Caenorhabditis elegans)
REACT:R-GGA-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Gallus gallus)
REACT:R-CEL-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Caenorhabditis elegans)
RHEA:45819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + A <=> AH2 + pyruvate
REACT:R-HSA-8864381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A,TFAP2C homodimers bind ESR1 promoter (Homo sapiens)
REACT:R-HSA-202722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD48 binds CD244 (Homo sapiens)
REACT:R-SPO-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Schizosaccharomyces pombe)
REACT:R-RNO-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Rattus norvegicus)
REACT:R-SCE-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Saccharomyces cerevisiae)
REACT:R-CEL-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Caenorhabditis elegans)
GO:0050119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine deacetylase activity
GO:0050119	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-glucosaminyl N-deacetylase activity
GO:0050119	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylaminodeoxyglucose acetylhydrolase activity
GO:0050119	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-glucosamine amidohydrolase activity
RHEA:71520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(out) => uridine(in)
GO:0050182	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butanoyl-CoA:phosphate butanoyltransferase activity
GO:0050182	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotransbutyrylase activity
GO:0050182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate butyryltransferase activity
REACT:R-CEL-8944216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XV (Caenorhabditis elegans)
REACT:R-MMU-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Mus musculus)
REACT:R-CEL-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Caenorhabditis elegans)
RHEA:69930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(out) + Na(+)(out) <=> adenosine(in) + Na(+)(in)
REACT:R-HSA-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Homo sapiens)
REACT:R-SCE-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Saccharomyces cerevisiae)
RHEA:56107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 <=> 4,4'-diaponeurosporenal + 2 A + 3 H2O
GO:0005261	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	non-selective cation channel activity
GO:0005261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation channel activity
GO:0005261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation diffusion facilitator activity
RHEA:20676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH
REACT:R-CEL-77340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Caenorhabditis elegans)
GO:0102199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide reductase activity (NAD(P)H-dependent) activity
GO:0030787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 4-methyltransferase activity
GO:0030787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol 6-O-methyltransferase activity
GO:0030787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol 4-O-methyltransferase activity
GO:0030787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity
GO:0030787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity
REACT:R-SSC-879584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO3A1 isoform 1 has abroad substrate specificity (Sus scrofa)
RHEA:63013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + orsellinate => diphosphate + ilicicolinate B
RHEA:62346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + notoamide S => 6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate
REACT:R-CFA-1605591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Canis familiaris)
RHEA:59847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)
REACT:R-DRE-5687097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3 binds ETV4 (Danio rerio)
REACT:R-XTR-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Xenopus tropicalis)
RHEA:35403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) = (3R)-vestitone + H(+) + NADPH
RHEA:35403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) = a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH
RHEA:35403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(3R)-2'-hydroxyisoflavanone reductase"
RHEA:35403	skos:prefLabel	"(3R)-2'-hydroxyisoflavanone reductase"
RHEA:35403	skos:altLabel	"vestitone reductase"
RHEA:24708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose => (6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose
REACT:R-SSC-5675433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP5 dephosphorylates RAF1 S338 (Sus scrofa)
REACT:R-XTR-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Xenopus tropicalis)
REACT:R-HSA-9668902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18-RFC(7s) complex (Homo sapiens)
REACT:R-BTA-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Bos taurus)
REACT:R-GGA-8948034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds LDL:LRP8 (Gallus gallus)
REACT:R-RNO-3232162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates MITF with SUMO1 (Rattus norvegicus)
GO:0052769	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	exosulfoglycosidase activity
GO:0052769	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sulfoglycosidase activity
GO:0052769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-6-sulfate-N-acetylglucosaminidase activity
GO:0052769	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-6-SO3-N-acetylglucosaminidase activity
GO:0052769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfomucin beta-6-sulfate-N-acetylglucosaminidase activity
REACT:R-PFA-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Plasmodium falciparum)
GO:0034839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menth-2-enone hydratase activity
REACT:R-DRE-196026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dab2 is recruited to the junctional plaques (Danio rerio)
GO:0018584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,5-trichlorophenoxyacetic acid oxygenase activity
GO:0018584	skos:prefLabel	"Miscellaneous"
GO:0018584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Miscellaneous"
REACT:R-MMU-8935732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds SIN3A,(SIN3B) co-repressor (Mus musculus)
RHEA:19442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + O2 => 3-hydroxy-cis,cis-muconate + 2 H(+)
GO:0050204	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxalomalate glyoxylate-lyase activity
GO:0050204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalomalate lyase activity
GO:0050204	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)
REACT:R-GGA-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Gallus gallus)
RHEA:16664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoride + S-adenosyl-L-methionine <=> 5'-deoxy-5'-fluoroadenosine + L-methionine
REACT:R-RNO-8952625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
REACT:R-HSA-210271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and MDL-1 (Homo sapiens)
RHEA:72380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + iodide(in) => chloride(in) + iodide(out)
RHEA:46096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + dihydropinosylvin
REACT:R-CEL-112379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of elongation factors to form elongation complex (Caenorhabditis elegans)
REACT:R-GGA-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)
RHEA:21805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + myo-inositol => 1D-myo-inositol 3-phosphate + ADP + H(+)
REACT:R-HSA-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Homo sapiens)
REACT:R-HSA-5676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD74 binds MIF (Homo sapiens)
REACT:R-GGA-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Gallus gallus)
RHEA:54701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)
RHEA:36168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate
REACT:R-HSA-9683393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp15 binds nsp8 (Homo sapiens)
RHEA:41379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)
REACT:R-CEL-3780994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Caenorhabditis elegans)
RHEA:10938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-decylubiquinol + tetrathionate => 6-decylubiquinone + 2 thiosulfate
RHEA:47074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoate + glycerol + H(+) => 1-eicosanoylglycerol + H2O
RHEA:11421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + senecionine => H2O + NADP(+) + senecionine N-oxide
REACT:R-HSA-390597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Homo sapiens)
REACT:R-XTR-8982163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Xenopus tropicalis)
RHEA:66699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-PFA-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Plasmodium falciparum)
REACT:R-BTA-2309773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS2 (Bos taurus)
REACT:R-BTA-109699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
REACT:R-RNO-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Rattus norvegicus)
REACT:R-RNO-6797803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds SLITRK1-6 (Rattus norvegicus)
RHEA:11954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxopropanoate => 3-hydroxypyruvate
REACT:R-HSA-8985157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAS3 binds viral dsRNA (Homo sapiens)
RHEA:36650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine
REACT:R-XTR-2160892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Xenopus tropicalis)
REACT:R-MMU-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Mus musculus)
RHEA:62006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose
REACT:R-CFA-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)
GO:0047933	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose 1,6-diphosphate synthase activity
GO:0047933	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity
GO:0047933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-1,6-bisphosphate synthase activity
GO:0047933	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose-1,6-bisphosphate synthetase activity
GO:0047933	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity
RHEA:18800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:45222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein]
RHEA:46132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADPH + O2 = 25-hydroxycholesterol + H2O + NADP(+)
REACT:R-DME-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)
GO:0046567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aphidicolan-16 beta-ol synthase activity
GO:0046567	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	9-alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16-beta-ol-forming)
RHEA:14835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH => (R)-mevalonate + CoA + 2 NAD(+)
RHEA:31812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + viridiflorene
EC:1.6.2.4	skos:altLabel	"NADPH--cytochrome P450 oxidoreductase"
EC:1.6.2.4	skos:altLabel	"aldehyde reductase (NADPH-dependent)"
EC:1.6.2.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADPH--hemoprotein reductase"
EC:1.6.2.4	skos:altLabel	"NADP--cytochrome c reductase"
EC:1.6.2.4	skos:altLabel	"NADPH--ferrihemoprotein reductase"
EC:1.6.2.4	skos:altLabel	"NADPH:ferrihemoprotein oxidoreductase"
EC:1.6.2.4	skos:altLabel	"FAD-cytochrome c reductase"
EC:1.6.2.4	skos:altLabel	"NADPH-dependent cytochrome c reductase"
EC:1.6.2.4	skos:prefLabel	"NADPH--hemoprotein reductase"
EC:1.6.2.4	skos:altLabel	"reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase"
EC:1.6.2.4	skos:altLabel	"ferrihemoprotein P-450 reductase"
EC:1.6.2.4	skos:altLabel	"TPNH-cytochrome c reductase"
EC:1.6.2.4	skos:altLabel	"NADPH--ferricytochrome c oxidoreductase"
EC:1.6.2.4	skos:altLabel	"cytochrome P450 reductase"
EC:1.6.2.4	skos:altLabel	"CPR"
EC:1.6.2.4	skos:altLabel	"NADPH--cytochrome c oxidoreductase"
EC:1.6.2.4	skos:altLabel	"TPNH2 cytochrome c reductase"
EC:1.6.2.4	skos:altLabel	"NADPH--cytochrome P450 reductase"
EC:1.6.2.4	skos:altLabel	"NADPH:P450 reductase"
EC:1.6.2.4	skos:altLabel	"reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)"
EC:1.6.2.4	skos:altLabel	"dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase"
EC:1.6.2.4	skos:altLabel	"cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent)"
EC:1.6.2.4	skos:altLabel	"NADP--cytochrome reductase"
EC:1.6.2.4	skos:altLabel	"NADPH--cytochrome c reductase"
REACT:R-RNO-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Rattus norvegicus)
RHEA:38364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoylglycerol + H2O => glycerol + H(+) + octadecanoate
REACT:R-MMU-5692781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Mus musculus)
RHEA:40954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetamido-4-aminobutanoate + H2O <=> acetate + L-2,4-diaminobutanoate
GO:0047151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity
GO:0047151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity
GO:0047151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity
GO:0047151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folate-dependent ribothymidyl synthase activity
GO:0047151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity
GO:0047151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity
RHEA:59347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + O2 <=> D-maltobiono-1,5-lactone + H2O2
REACT:R-MMU-210285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homophilic interaction of PECAM-1 (Mus musculus)
REACT:R-XTR-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)
RHEA:32955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate
REACT:R-MMU-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Mus musculus)
RHEA:34363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylgalactosamine diphosphorylase"
RHEA:34363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-galactosamine
RHEA:34363	skos:prefLabel	"UDP-N-acetylgalactosamine diphosphorylase"
RHEA:53652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate
REACT:R-MMU-2187332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic CMs translocate to extracellular region (Mus musculus)
REACT:R-DRE-8851550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside diphosphates (Danio rerio)
RHEA:11241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine diphosphate => ADP + thiamine triphosphate
REACT:R-CFA-6800798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome binds CASP2 (Canis familiaris)
REACT:R-MMU-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
REACT:R-HSA-2730884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)
REACT:R-CEL-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Caenorhabditis elegans)
REACT:R-CEL-751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gz complex dissociates (Caenorhabditis elegans)
REACT:R-MMU-8943041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Mus musculus)
RHEA:11977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anhydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrotetracycline + H2O + NADP(+)
RHEA:65727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + pentyl sulfate <=> CO2 + H(+) + pentanal + succinate + sulfate
RHEA:65887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-hydroxy-L-kynurenine <=> H2O + L-glutamate + xanthurenate
RHEA:53129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-carotene => epsilon-carotene
EC:3.4.24.83	skos:altLabel	"lethal toxin"
EC:3.4.24.83	skos:prefLabel	"anthrax lethal factor endopeptidase"
EC:3.4.24.83	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthrax lethal factor endopeptidase"
RHEA:21974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-2 + S-adenosyl-L-homocysteine => precorrin-1 + S-adenosyl-L-methionine
REACT:R-RNO-2395849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
RHEA:52055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-hexadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + hexadecanoate
REACT:R-XTR-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Xenopus tropicalis)
RHEA:28374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
REACT:R-BTA-111751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)
REACT:R-SSC-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Sus scrofa)
GO:0102545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidyl phospholipase B activity
REACT:R-MMU-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Mus musculus)
RHEA:60838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate => a 5'-end diphospho-adenosine in mRNA + GTP + H(+)
GO:0030266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinate:NAD(+) 5-oxidoreductase activity
GO:0030266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinate 3-dehydrogenase (NAD+) activity
GO:0030266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinate:NAD 3-oxidoreductase activity
GO:0030266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinate:NAD 5-oxidoreductase activity
GO:0030266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinate:NAD(+) 3-oxidoreductase activity
GO:0030266	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	quinic dehydrogenase activity
REACT:R-GGA-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Gallus gallus)
REACT:R-XTR-9661397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)
REACT:R-BTA-8856630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIDEA:CIDEC binds lipid droplets (Bos taurus)
REACT:R-CFA-8983878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Canis familiaris)
REACT:R-XTR-187828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p21 to the nucleus (Xenopus tropicalis)
REACT:R-CFA-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Canis familiaris)
RHEA:45008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(octadecanoyl)-sphinganine = octadecanoate + sphinganine
REACT:R-XTR-2465924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1LW binds 11cRAL (Xenopus tropicalis)
RHEA:34394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose <=> [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP
REACT:R-CFA-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)
REACT:R-SPO-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Schizosaccharomyces pombe)
REACT:R-DRE-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Danio rerio)
RHEA:45396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
GO:0001791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgM binding
RHEA:23099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)
GO:0103082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(4'-methylthio)butylmalate synthase activity
RHEA:54229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine
RHEA:39144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH
RHEA:54614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylbutanoyl-CoA + O2
REACT:R-PFA-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Plasmodium falciparum)
REACT:R-RNO-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Rattus norvegicus)
REACT:R-HSA-2395324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyrrole cross-links (Homo sapiens)
REACT:R-GGA-170978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-FRS2:CRKL binds C3G (Gallus gallus)
RHEA:56229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-SSC-6797653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMGDH:FAD oxidatively demethylates DMGLY to SARC (Sus scrofa)
REACT:R-BTA-5692283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)
REACT:R-SCE-1299359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TALK (Saccharomyces cerevisiae)
RHEA:69780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxindole-3-acetate + succinyl-CoA => (2-oxoindol-3-yl)acetyl-CoA + succinate
RHEA:57268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate
RHEA:23398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,5-trihydroxybenzene + H(+) + phloretate => H2O + phloretin
REACT:R-XTR-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Xenopus tropicalis)
RHEA:67519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-XTR-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Xenopus tropicalis)
REACT:R-HSA-5333671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCAs self cleave (Homo sapiens)
REACT:R-SSC-3788748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL6 promoter (Sus scrofa)
RHEA:48154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GD1b(d18:1(4E)/18:0) + H2O
RHEA:27663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + O2 => 2-oxoglutarate + H2O2
EC:1.1.7.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With an iron-sulfur protein as acceptor"
EC:1.1.7.-	skos:prefLabel	"With an iron-sulfur protein as acceptor"
REACT:R-HSA-8878143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SMAD3 and SMAD4 (Homo sapiens)
GO:0044540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine L-cysteine-lyase (deaminating)
GO:0044540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cystine = NH4(+) + pyruvate + S-sulfanyl-L-cysteine
GO:0044540	skos:prefLabel	"L-cystine beta-lyase"
GO:0044540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-cystine beta-lyase"
GO:0080097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
GO:0080097	skos:prefLabel	"L-tryptophan--pyruvate aminotransferase"
GO:0080097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-tryptophan--pyruvate aminotransferase"
GO:0080097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan:pyruvate aminotransferase activity
REACT:R-DME-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Drosophila melanogaster)
REACT:R-DRE-76052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIA To type 1 Promoter (Danio rerio)
REACT:R-XTR-879909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of STAT5a/b by JAK2 (Xenopus tropicalis)
RHEA:21449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] => 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate
REACT:R-HSA-5682983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates WHSC1 (Homo sapiens)
REACT:R-RNO-429955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR4-NOT complex deadenylates mRNA (Rattus norvegicus)
REACT:R-CFA-8851899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Canis familiaris)
RHEA:38303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glucosaminate-6-phosphate ammonia lyase"
RHEA:38303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate 6-phosphate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)
RHEA:38303	skos:prefLabel	"D-glucosaminate-6-phosphate ammonia lyase"
RHEA:45102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitomycin B + S-adenosyl-L-homocysteine => 6-demethylmitomycin B + S-adenosyl-L-methionine
RHEA:45375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-sphinganine <=> (9Z)-octadecenoate + sphinganine
REACT:R-HSA-4551649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO1 (Homo sapiens)
REACT:R-SSC-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Sus scrofa)
RHEA:68467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-butyloctyl sulfate + H2O <=> 2-butyloctan-1-ol + H(+) + sulfate
REACT:R-DRE-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Danio rerio)
REACT:R-DME-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Drosophila melanogaster)
REACT:R-XTR-4615872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO1 (Xenopus tropicalis)
REACT:R-GGA-977602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to MCP, CR1:C4b, C3b (Gallus gallus)
REACT:R-HSA-2404135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4 binds atROL (Homo sapiens)
GO:0000994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III core binding
REACT:R-XTR-9712210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Xenopus tropicalis)
REACT:R-HSA-195378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of VEGF proteins (Homo sapiens)
RHEA:37105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O
REACT:R-DME-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)
REACT:R-MMU-9696179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Mus musculus)
RHEA:52195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:38263	skos:altLabel	"mesaconyl-coenzyme A hydratase"
RHEA:38263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-beta-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O
RHEA:38263	skos:prefLabel	"2-methylfumaryl-CoA hydratase"
RHEA:38263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methylfumaryl-CoA hydratase"
RHEA:38263	skos:altLabel	"mesaconyl-C1-CoA hydratase"
RHEA:38263	skos:altLabel	"erythro-beta-methylmalonyl-CoA hydrolyase"
RHEA:16320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-indan-1-ol + NAD(+) <=> H(+) + indan-1-one + NADH
REACT:R-BTA-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Bos taurus)
RHEA:52133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O => a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)
RHEA:68264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formaldehyde
REACT:R-SPO-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)
RHEA:69709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactose + N-hexadecanoylsphinganine => beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O
REACT:R-DRE-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Danio rerio)
GO:0004308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialidase activity
GO:0004308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylneuraminyl hydrolase activity
GO:0004308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acylneuraminate glycohydrolase activity
GO:0004308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-alpha-sialidase activity
GO:0004308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neuraminidase activity
GO:0004308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylneuraminidase activity
GO:0004308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-neuraminidase activity
RHEA:57461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP
REACT:R-XTR-6798257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRS binds NTRK3 (Xenopus tropicalis)
GO:0030695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	small GTPase regulator activity
GO:0030695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTPase regulator activity
GO:0030695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	small GTPase regulatory/interacting protein activity
REACT:R-SCE-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Saccharomyces cerevisiae)
REACT:R-XTR-170824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Xenopus tropicalis)
RHEA:38247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + hexadecan-1-ol = 1-O-hexadecyl (9Z)-hexadecenoate + CoA
REACT:R-HSA-879782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of AVP (Homo sapiens)
REACT:R-RNO-202365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)
REACT:R-HSA-975118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
RHEA:10186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O
REACT:R-HSA-8850997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 binds PTEN (Homo sapiens)
REACT:R-DRE-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Danio rerio)
REACT:R-DRE-111238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR2  homodimer (Danio rerio)
REACT:R-DRE-2168038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XV restin release (Danio rerio)
REACT:R-HSA-5690845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNIPs bind TNFAIP3 (A20) (Homo sapiens)
REACT:R-RNO-5635864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH ubiquitinates GLI1 (Rattus norvegicus)
RHEA:52423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-phospho-L-serine + thiosulfate <=> phosphate + S-sulfo-L-cysteine
GO:0004947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bradykinin receptor activity
REACT:R-HSA-6809680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTM1 (Homo sapiens)
REACT:R-BTA-2031355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)
RHEA:71559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-N(alpha)-glycyl-dTMP in DNA + A + H2O = 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate
RHEA:68409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-iso(homo)3citrate + NAD(+) => 2-oxosuberate + CO2 + NADH
REACT:R-XTR-9648949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A antagonists bind HTR3A pentamer (Xenopus tropicalis)
GO:0033142	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	progesterone receptor binding
GO:0033142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear progesterone receptor binding
REACT:R-MMU-3000433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PML with SUMO3 (Mus musculus)
REACT:R-DME-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Drosophila melanogaster)
REACT:R-GGA-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Gallus gallus)
RHEA:15066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-benzoylagmatine => agmatine + benzoate
RHEA:21430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pyruvate + sulfite => (2R)-3-sulfolactate
REACT:R-XTR-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Xenopus tropicalis)
REACT:R-DRE-1855197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)
REACT:R-BTA-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Bos taurus)
RHEA:27882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-CMP + H2O = 3'-CMP + H(+)
RHEA:34005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrodesmosterol + 2 H2O + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2
REACT:R-BTA-9014456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOG (Bos taurus)
RHEA:65792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-5691439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRISC complex deubiquitinates NLRP3 (Bos taurus)
RHEA:69854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in mRNA + NAD(+) <=> a uridine in mRNA + H(+) + NADH
RHEA:51756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6-diprenylphloroglucinol + diphosphate
RHEA:29968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine(in) + H(+)(in) => 2'-deoxyuridine(out) + H(+)(out)
REACT:R-XTR-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Xenopus tropicalis)
REACT:R-XTR-211962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F11 16-hydroxylates 3OH-PALM (Xenopus tropicalis)
RHEA:53326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin E2 => 2-glyceryl-prostaglandin H2
REACT:R-DME-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Drosophila melanogaster)
RHEA:48267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] <=> H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate
REACT:R-HSA-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Homo sapiens)
REACT:R-SCE-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Saccharomyces cerevisiae)
GO:0003725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dsRNA binding
GO:0003725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded RNA binding
REACT:R-SSC-4608855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRICKLE1 is degraded by the proteasome (Sus scrofa)
REACT:R-RNO-204861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shc1 (Rattus norvegicus)
RHEA:61915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + voriconazole(in) <=> ADP + H(+) + phosphate + voriconazole(out)
RHEA:64162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase] => ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide
REACT:R-BTA-8851538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside triphosphates (Bos taurus)
RHEA:20654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23,24-dihydrocucurbitacin B + NAD(+) => cucurbitacin B + H(+) + NADH
GO:0030791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:arsenite As-methyltransferase activity
GO:0030791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:arsenic(III) methyltransferase activity
GO:0030791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity
GO:0030791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite methyltransferase activity
REACT:R-GGA-166795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Classical C3 convertase (C4b:C2a complex) (Gallus gallus)
GO:0103080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3-methylsulfanyl)propylmalate = 3-(3-methylsulfanyl)propylmalate
GO:0103080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiopropylmalate isomerase activity
REACT:R-CEL-9632906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ recruits RAS in response to estrogen stimulation (Caenorhabditis elegans)
REACT:R-RNO-622310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD1 oligomerizes (Rattus norvegicus)
RHEA:52132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)
RHEA:34419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-lariciresinol + NADP(+) = (+)-pinoresinol + H(+) + NADPH
RHEA:34419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-pinoresinol reductase"
RHEA:34419	skos:altLabel	"(+)-pinoresinol-(+)-lariciresinol reductase"
RHEA:34419	skos:altLabel	"(+)-pinoresinol/(+)-lariciresinol"
RHEA:34419	skos:prefLabel	"(+)-pinoresinol reductase"
RHEA:34419	skos:altLabel	"pinoresinol-lariciresinol reductases"
RHEA:34419	skos:altLabel	"pinoresinol/lariciresinol reductase"
RHEA:48256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
REACT:R-HSA-2534240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) degradation by MMP14, MMP15 (Homo sapiens)
REACT:R-DME-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Drosophila melanogaster)
REACT:R-CFA-5684882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 is recruited to resected DNA DSBs (Canis familiaris)
GO:0090565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-mannitol phosphotransferase system transporter activity
REACT:R-DME-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Drosophila melanogaster)
REACT:R-MMU-9649108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer binds 5HT (Mus musculus)
REACT:R-XTR-3149494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC:cob(II)alamin binds MMADHC (Xenopus tropicalis)
RHEA:16224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RHEA:40582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)
GO:0015087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
GO:0015087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(2+)(in) = Co(2+)(out)
GO:0015087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt ion transmembrane transporter activity
GO:0015087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cobalt, zinc uptake permease activity
REACT:R-MMU-2187330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)
REACT:R-CFA-5218916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPK2/3 phosphorylates HSP27 (Canis familiaris)
RHEA:63230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-O-adenylylspectinomycin + diphosphate => ATP + spectinomycin
REACT:R-RNO-374701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DCC by Fyn (Rattus norvegicus)
RHEA:38490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)
RHEA:51294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + L-methionyl-(S)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]
REACT:R-HSA-164504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of minus strand strong stop DNA (-sssDNA) (Homo sapiens)
RHEA:17408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine <=> H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine
GO:0030226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein receptor activity
REACT:R-MMU-9025996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Mus musculus)
RHEA:72560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + pentanoate(in) => estrone 3-sulfate(in) + pentanoate(out)
RHEA:70889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + L-serine(in) + Na(+)(in) => L-glutamine(in) + L-serine(out) + Na(+)(out)
RHEA:70466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 <=> a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate
RHEA:65826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:44851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-tetradecenoyl-(R)-carnitine
REACT:R-DRE-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Danio rerio)
REACT:R-MMU-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Mus musculus)
GO:0047923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gentisate carboxy-lyase activity
GO:0047923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)
GO:0047923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-dihydroxybenzoate decarboxylase activity
GO:0047923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gentisate decarboxylase activity
RHEA:44107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanal + H2O + NAD(+) <=> decanoate + 2 H(+) + NADH
REACT:R-SSC-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Sus scrofa)
REACT:R-DRE-8869425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA1A hydrolyses PS to 2-acyl LPS (Danio rerio)
RHEA:18364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl D-xylosyl phosphate + L-seryl-[protein] <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)
RHEA:69655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + quercetin 3-O-beta-D-glucoside = beta-D-glucose + quercetin
REACT:R-GGA-5693608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial resection of double-strand break ends (Gallus gallus)
RHEA:72189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + sucrose(in) => H(+)(out) + sucrose(out)
RHEA:69125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-tryptophan => glycine + indole-3-pyruvate
REACT:R-GGA-5623525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo-carrying vesicles bud from the TGN (Gallus gallus)
RHEA:13064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + S-sulfanylglutathione <=> glutathione S,S-dioxide + H(+)
REACT:R-GGA-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Gallus gallus)
RHEA:49710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isonocardicin C + S-methyl-5'-thioadenosine => nocardicin G + S-adenosyl-L-methionine
RHEA:53028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP
REACT:R-SPO-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Schizosaccharomyces pombe)
REACT:R-PFA-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Plasmodium falciparum)
RHEA:11531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate
RHEA:33663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine
REACT:R-HSA-199917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)
RHEA:22679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H(+) + NADPH + O2 <=> 7(1)-hydroxychlorophyllide a + H2O + NADP(+)
REACT:R-XTR-9647746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 trimerizes (Xenopus tropicalis)
RHEA:34608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine => a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine
RHEA:33404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonine => diphosphate + L-threonyl-5'-AMP
RHEA:26272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-2 + 3 H(+) <=> Co(2+) + precorrin-2
RHEA:15612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
REACT:R-SPO-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Schizosaccharomyces pombe)
RHEA:47360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoate ester + H2O = an aliphatic alcohol + decanoate + H(+)
REACT:R-BTA-139970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO3:FAD N-oxidises TMA to TMAO (Bos taurus)
GO:0004321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)
GO:0004321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acyl CoA synthase activity
GO:0004321	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	yeast fatty acid synthase activity
GO:0004321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty-acyl-CoA synthase activity
RHEA:56299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] <=> pyruvate + S-sulfanyl-L-cysteinyl-[protein]
REACT:R-RNO-373732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin trans-homophilic interaction (Rattus norvegicus)
REACT:R-BTA-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Bos taurus)
REACT:R-HSA-9733973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts bind FABP6 (Homo sapiens)
REACT:R-HSA-9686343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAV NS1 binds MLKL (Homo sapiens)
REACT:R-MMU-444705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R1/T1R3 dimer is the umami taste receptor (Mus musculus)
REACT:R-XTR-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Xenopus tropicalis)
REACT:R-MMU-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)
RHEA:29625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltohexaose + beta-D-glucose => alpha-maltopentaose + beta-maltose
RHEA:31001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitadienol => (S)-2,3-epoxysqualene
RHEA:35223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-dADP + H2O = 2-oxo-dAMP + H(+) + phosphate
RHEA:70545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose
REACT:R-DRE-2530429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of soluble VTN:C5b-C9  (Danio rerio)
GO:0034524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisophthalate decarboxylase activity
RHEA:16660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + inosine <=> D-ribose + hypoxanthine
RHEA:22430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + isopenicillin N => N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
REACT:R-DME-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Drosophila melanogaster)
REACT:R-SCE-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Saccharomyces cerevisiae)
REACT:R-SSC-5655170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 monoubiquitinates POLH (Sus scrofa)
REACT:R-SSC-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
RHEA:24572	skos:altLabel	"sucrose--glucan glucosyltransferase"
RHEA:24572	skos:prefLabel	"amylosucrase"
RHEA:24572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amylosucrase"
RHEA:24572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + sucrose = [(1->4)-alpha-D-glucosyl](n+1) + D-fructose
RHEA:58112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1''-O-acetyl-ADP-alpha-D-ribose + H2O = acetate + ADP-D-ribose + H(+)
REACT:R-HSA-3296477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective AMN does not transport GIF:Cbl (Homo sapiens)
REACT:R-RNO-9679740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA4:ITGB1 binds natalizumab (Rattus norvegicus)
REACT:R-CFA-140686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Canis familiaris)
REACT:R-BTA-139917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID activates BAX protein (Bos taurus)
REACT:R-XTR-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Xenopus tropicalis)
REACT:R-BTA-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Bos taurus)
REACT:R-CFA-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Canis familiaris)
RHEA:50811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin J2 <=> prostaglandin J2-S-(S)-glutathione
REACT:R-HSA-5688025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective pro-SFTPB does not translocate from ER membrane to multivesicle body (Homo sapiens)
RHEA:64821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetamide + H2O => 2-phenylacetate + NH4(+)
GO:0043750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity
GO:0043750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidyl-myo-inositol alpha-mannosyltransferase activity
GO:0043750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity
GO:0043750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity
GO:0043750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity
GO:0043750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol alpha-mannosyltransferase activity
GO:0043750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity
RHEA:56663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
RHEA:61977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]
REACT:R-XTR-5634228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 is cleaved by caspases (Xenopus tropicalis)
REACT:R-HSA-451403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)
REACT:R-GGA-162830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)
REACT:R-RNO-165182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of complexed TSC2 by PKB (Rattus norvegicus)
RHEA:56178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+) => 8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O
REACT:R-GGA-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Gallus gallus)
GO:0140523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	membrane fusion GTPase activity
GO:0140523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTPase-dependent fusogenic activity
GO:0140944	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H4K20 methylase activity
GO:0140944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K20 monomethyltransferase activity
GO:0140944	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H4-K20 methylation
GO:0140944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-monomethyltransferase activity (H4-K20 specific)
GO:0140944	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H4K20 methylation
EC:1.10.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a cytochrome as acceptor"
EC:1.10.2.-	skos:prefLabel	"With a cytochrome as acceptor"
RHEA:68219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA
REACT:R-DME-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Drosophila melanogaster)
RHEA:54670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-onocerin => pre-alpha-onocerin
RHEA:29073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + CO2 => a ubiquinone + formate + H(+)
REACT:R-MMU-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Mus musculus)
GO:0042960	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	antimonite porter activity
GO:0042960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	antimonite secondary active transmembrane transporter activity
GO:0102396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-10'-apo-beta-carotenal cleavage oxygenase activity
REACT:R-BTA-373087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR6 binds CCL20 ligand (Bos taurus)
RHEA:16955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + N-succinyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-succinyl-L-ornithine
REACT:R-CFA-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Canis familiaris)
REACT:R-DME-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Drosophila melanogaster)
RHEA:34151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine = 2-deoxystreptamine + 2-oxoglutaramate
RHEA:34151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase"
RHEA:34151	skos:prefLabel	"L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase"
REACT:R-XTR-1433488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHP2 by SFKs (Xenopus tropicalis)
REACT:R-BTA-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Bos taurus)
REACT:R-SSC-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Sus scrofa)
RHEA:25941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-chloroquinoline + A + H2O => 8-chloroquinolin-2(1H)-one + AH2
REACT:R-RNO-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Rattus norvegicus)
RHEA:16129	skos:altLabel	"PL reductase"
RHEA:16129	skos:altLabel	"pyridoxine dehydrogenase"
RHEA:16129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal
RHEA:16129	skos:altLabel	"pyridoxal reductase"
RHEA:16129	skos:prefLabel	"pyridoxine 4-dehydrogenase"
RHEA:16129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxine 4-dehydrogenase"
REACT:R-SSC-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Sus scrofa)
RHEA:70197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate => ATP + deamido-NAD(+)
RHEA:14467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidinol + phosphate => H2O + L-histidinol phosphate
RHEA:35505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:28407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XTP => H(+) + phosphate + XDP
RHEA:21137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + acetyl-CoA => CoA + O-acetyl-(R)-carnitine
RHEA:19764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-N(5)-oxide + H(+) + NADH <=> FMN + H2O + NAD(+)
GO:0050313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfur oxygenase activity
GO:0050313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-sulfanylglutathione:oxygen oxidoreductase activity
GO:0050313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfur:oxygen oxidoreductase activity
GO:0050313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur dioxygenase activity
GO:0050313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphur dioxygenase activity
REACT:R-HSA-9008478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXW7 binds RUNX2 and GSK3B (Homo sapiens)
REACT:R-CFA-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Canis familiaris)
REACT:R-XTR-6799761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds PPP1R13L (Xenopus tropicalis)
REACT:R-CFA-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Canis familiaris)
GO:0008188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuropeptide receptor activity
REACT:R-MMU-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Mus musculus)
RHEA:59948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin F2alpha-CoA = CoA + H(+) + prostaglandin F2alpha
RHEA:25788	skos:altLabel	"2,4-dihydroxyhept-2-enedioate aldolase"
RHEA:25788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-2-oxoheptanedioate aldolase"
RHEA:25788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde
RHEA:25788	skos:prefLabel	"4-hydroxy-2-oxoheptanedioate aldolase"
RHEA:25788	skos:altLabel	"HKHD aldolase"
RHEA:25788	skos:altLabel	"HHED aldolase"
RHEA:25788	skos:altLabel	"4-hydroxy-2-ketoheptanedioate aldolase"
GO:0032050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clathrin heavy chain binding
EC:3.2.1.11	skos:altLabel	"alpha-1,6-glucan-6-glucanohydrolase"
EC:3.2.1.11	skos:prefLabel	"dextranase"
EC:3.2.1.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dextranase"
REACT:R-MMU-6800315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 binds MST1R (Mus musculus)
REACT:R-SSC-2730837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-10Y-NTAL (Sus scrofa)
REACT:R-GGA-5607747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MALT1 oligomers (Gallus gallus)
RHEA:37334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionyl-L-alanine <=> L-alanine + L-methionine
GO:0034843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaryl-CoA thioesterase activity
REACT:R-HSA-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Homo sapiens)
REACT:R-PFA-110349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of UNG glycosylase by APEX1 at the AP site (Plasmodium falciparum)
RHEA:14275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + AH2 + propane-1,3-diamine => A + H2O + spermidine
RHEA:18210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (2S,4R)-bornyl diphosphate
REACT:R-SSC-448632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimerizes (Sus scrofa)
REACT:R-RNO-2267372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Rattus norvegicus)
REACT:R-MMU-9604487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7:p-IRF7 translocates to the nucleus (Mus musculus)
REACT:R-CFA-8849085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RHOA:GTP (Canis familiaris)
REACT:R-DME-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Drosophila melanogaster)
RHEA:52824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
REACT:R-SSC-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Sus scrofa)
REACT:R-DRE-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Danio rerio)
GO:0034916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexanoyl-CoA dehydrogenase activity
REACT:R-HSA-8987097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Homo sapiens)
RHEA:35923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP
RHEA:35304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisopentadecanoyl-CoA + NADP(+) => 3-oxoisopentadecanoyl-CoA + H(+) + NADPH
RHEA:64447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine
REACT:R-GGA-9646685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggresome dissociates from dynein and microtubule (Gallus gallus)
REACT:R-DME-9733969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts dissociate from FABP6 (Drosophila melanogaster)
RHEA:52685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pyridoxine => H(+) + NADH + pyridoxal
RHEA:38800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:34114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine
REACT:R-DME-9708517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Drosophila melanogaster)
REACT:R-SSC-1028817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Sus scrofa)
REACT:R-BTA-5676598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:cIAP1/2 complex binds FN14:TWEAK (Bos taurus)
REACT:R-SCE-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Saccharomyces cerevisiae)
REACT:R-DRE-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Danio rerio)
REACT:R-CEL-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Caenorhabditis elegans)
RHEA:64097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]
REACT:R-HSA-389995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Homo sapiens)
REACT:R-HSA-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Homo sapiens)
REACT:R-XTR-113503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A mediated localization of RB1 protein in chromatin (Xenopus tropicalis)
RHEA:14503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+) => H2O + L-homocysteine
REACT:R-SSC-5610725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TULP3 is required for GPR161 localization in the cilium (Sus scrofa)
RHEA:10146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside + phosphate => a ribonucleoside 3'-phosphate + H2O
RHEA:63738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethanol + NADP(+) => 2-phenylacetaldehyde + H(+) + NADPH
REACT:R-CFA-5696947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP47 deubiquitinates POLB (Canis familiaris)
RHEA:55962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + gamma-butyrobetainyl-CoA => 4-(trimethylamino)butanoate + ATP + CoA
REACT:R-SCE-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)
REACT:R-SSC-8874685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds MET (Sus scrofa)
RHEA:22587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + heme b <=> Fe(2+) + protoporphyrin IX
REACT:R-CEL-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:38788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:42669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnofuranose + NADP(+) => H(+) + L-rhamnono-1,4-lactone + NADPH
REACT:R-XTR-9014449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the plasma membrane (Xenopus tropicalis)
REACT:R-BTA-9029150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Bos taurus)
REACT:R-CEL-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)
REACT:R-GGA-352945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP (Gallus gallus)
RHEA:66823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mn(2+)(in) <=> ADP + H(+) + Mn(2+)(out) + phosphate
RHEA:69310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetonitrile + sulfate + sulfur => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate
RHEA:14945	skos:altLabel	"1,2-diacylglycerol 3-beta-galactosyltransferase"
RHEA:14945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP
RHEA:14945	skos:altLabel	"UDP-galactose-diacylglyceride galactosyltransferase"
RHEA:14945	skos:altLabel	"UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase"
RHEA:14945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monogalactosyldiacylglycerol synthase"
RHEA:14945	skos:altLabel	"UDP galactose-1,2-diacylglycerol galactosyltransferase"
RHEA:14945	skos:altLabel	"uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase"
RHEA:14945	skos:altLabel	"1beta-MGDG"
RHEA:14945	skos:prefLabel	"monogalactosyldiacylglycerol synthase"
RHEA:14945	skos:altLabel	"MGDG synthase"
RHEA:14945	skos:altLabel	"UDP-galactose:diacylglycerol galactosyltransferase"
RHEA:24115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + O2 <=> glutathione disulfide + H2O2
GO:0030762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydrocolumbamine 2-O-methyltransferase activity
GO:0030762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrocolumbamine methyltransferase activity
GO:0030762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity
REACT:R-GGA-421452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O (Gallus gallus)
RHEA:36900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine
RHEA:24433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate => acetate + H(+) + oxalate
RHEA:49436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + deoxycholoyl-CoA = choloyl-CoA + deoxycholate
REACT:R-HSA-933528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of MEKK1 with TRAF6 (Homo sapiens)
GO:0051741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPBQ methyltransferase activity
GO:0051741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity
REACT:R-HSA-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Homo sapiens)
REACT:R-DRE-508162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Danio rerio)
REACT:R-DME-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Drosophila melanogaster)
REACT:R-HSA-2025723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the N-glycan precursor (Homo sapiens)
RHEA:16544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-violaxanthin + O2 <=> (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin
REACT:R-CEL-444731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Caenorhabditis elegans)
RHEA:67203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyltyramine <=> acetate + tyramine
RHEA:20369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H2O + O2 = glycine betaine + H(+) + H2O2
RHEA:47347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]
RHEA:38802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-BTA-71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Bos taurus)
REACT:R-GGA-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Gallus gallus)
RHEA:29501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-HSA-5423117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates MeK21-histone H4 (Homo sapiens)
RHEA:47456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) = 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH
GO:0034711	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	inhibin beta-A binding
GO:0034711	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	inhibin beta-B binding
GO:0034711	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	inhibin alpha binding
GO:0034711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inhibin monomer binding
GO:0034711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inhibin binding
REACT:R-RNO-8854408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOBR dimer binds VLDLs (Rattus norvegicus)
RHEA:45323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine <=> H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine
REACT:R-HSA-9766608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds type I PRMT inhibitors (Homo sapiens)
EC:3.4.23.24	skos:prefLabel	"candidapepsin"
EC:3.4.23.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"candidapepsin"
EC:3.4.23.24	skos:altLabel	"Candida albicans aspartic proteinase"
RHEA:47386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + hydroquinone => 4-acetoxyphenol + H2O
RHEA:21990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'''-demalonylsalvianin + CoA => malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside
GO:0005001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor protein tyrosine phosphatase activity
REACT:R-DME-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Drosophila melanogaster)
REACT:R-CFA-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)
RHEA:54310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine
RHEA:18066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphonate(out) => ADP + H(+) + phosphate + phosphonate(in)
RHEA:55683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate <=> anthranilate + H(+) + pyruvate
REACT:R-XTR-5665999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 translocates from cytosol to the nucleus (Xenopus tropicalis)
REACT:R-GGA-8879117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT2 transfers GlcNAc to Man-DAG1 (Gallus gallus)
REACT:R-RNO-9024326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Rattus norvegicus)
REACT:R-SSC-8987014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Sus scrofa)
RHEA:11185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(carbamoylamino)propanoate + 2 H(+) + H2O => beta-alanine + CO2 + NH4(+)
REACT:R-SSC-8944246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXI (Sus scrofa)
GO:0016209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	antioxidant activity
REACT:R-HSA-9666430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
REACT:R-RNO-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Rattus norvegicus)
RHEA:44747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 malonyl-CoA <=> (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O
REACT:R-PFA-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)
REACT:R-CEL-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Caenorhabditis elegans)
EC:1.11.1.-	skos:prefLabel	"Peroxidases"
EC:1.11.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Peroxidases"
RHEA:19545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerophosphocholine cholinephosphodiesterase"
RHEA:19545	skos:prefLabel	"glycerophosphocholine cholinephosphodiesterase"
RHEA:19545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + phosphocholine
RHEA:11735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B <=> H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-9726949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIR binds PTGIR agonists (Rattus norvegicus)
REACT:R-DRE-446877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is K63 poly-ubiquitinated (Danio rerio)
REACT:R-SSC-449087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD4 binds Interleukin-16 (Sus scrofa)
RHEA:63383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine
RHEA:70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxystyrene + H(+) + NADH <=> 4-ethylphenol + NAD(+)
RHEA:55957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + AH2 + O2 => (12R)-hydroxy-(9Z)-octadecenoate + A + H2O
RHEA:56098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal Gly-Gly-AMP + diphosphate => [protein]-C-terminal Gly-Gly + ATP + H(+)
REACT:R-XTR-3769393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ binds p-CBY:CTNNB1 (Xenopus tropicalis)
REACT:R-SSC-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Sus scrofa)
REACT:R-DDI-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-DRE-5218827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)
RHEA:42183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
EC:1.1.1.131	skos:prefLabel	"mannuronate reductase"
EC:1.1.1.131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannuronate reductase"
EC:1.1.1.131	skos:altLabel	"mannonate dehydrogenase"
REACT:R-SSC-2453833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Sus scrofa)
EC:2.4.1.222	skos:prefLabel	"O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase"
EC:2.4.1.222	skos:altLabel	"O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase"
EC:2.4.1.222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase"
REACT:R-XTR-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Xenopus tropicalis)
REACT:R-MMU-205328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other tyrosine kinases with p-KIT (Mus musculus)
REACT:R-RNO-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Rattus norvegicus)
RHEA:49889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2
REACT:R-HSA-1981157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of collagen propeptide hydroxylysines (Homo sapiens)
RHEA:54754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-HSA-204434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Homo sapiens)
REACT:R-SSC-8874849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBRF binds CREB3 (Sus scrofa)
RHEA:50945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + NAD(+) => (E)-cinnamate + H(+) + NADH
RHEA:58739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + TTP <=> 5-methyl-UMP + diphosphate + H(+)
RHEA:66128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-phenylalanine = (2S)-2-aminobutanoate + 3-phenylpyruvate
GO:1990407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGRP polypeptide binding
GO:1990407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitonin-gene-related polypeptide binding
GO:1990407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitonin gene-related peptide binding
GO:1990407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitonin-gene-related peptide binding
RHEA:31179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + H(+) + NADH
RHEA:40351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)
RHEA:69496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decan-1-ol + O2 = decanal + H2O2
RHEA:47315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5676595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAFs bind RANK:RANKL (Sus scrofa)
REACT:R-HSA-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Homo sapiens)
RHEA:22074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-ribulose 5-phosphate => ATP + L-ribulose
REACT:R-MMU-209960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diiodinated tyrosine can be deiodinated (Mus musculus)
REACT:R-HSA-9035982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HEXB does not cleave the terminal GalNAc from HA fragments (Homo sapiens)
RHEA:23837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methionine + pyruvate => 4-methylsulfanyl-2-oxobutanoate + L-alanine
GO:0097259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)
GO:0097259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-aldehyde-leukotriene B4 20-monooxygenase activity
RHEA:31609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene + H2O => rhodopin
REACT:R-DME-209199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CKA is phosphorylated by phosphorylated BSK kinase (Drosophila melanogaster)
REACT:R-CFA-390597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Canis familiaris)
RHEA:59134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + staphyloferrin B => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP
RHEA:70559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-galactosamine
RHEA:32362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + 2 ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)
GO:0001591	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dopamine D4 receptor activity
GO:0001591	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dopamine D3 receptor activity
GO:0001591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001591	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dopamine D2 receptor activity
RHEA:10385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate => beta-cyclopiazonate + diphosphate
RHEA:43755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]
REACT:R-SPO-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Schizosaccharomyces pombe)
REACT:R-CEL-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Caenorhabditis elegans)
REACT:R-DRE-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Danio rerio)
RHEA:58523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Xenopus tropicalis)
GO:0034554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-tribromobisphenol A reductive dehalogenase activity
REACT:R-SSC-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Sus scrofa)
REACT:R-BTA-8853793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET complexes bind GRB2 (Bos taurus)
GO:0047638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole monooxygenase activity
GO:0047638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	albendazole sulfoxidase activity
GO:0047638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)
GO:0047638	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	albendazole oxidase activity
GO:0047481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)
GO:0047481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanine-membrane acceptor-ligase activity
GO:0047481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine-alanyl-poly(glycerolphosphate) ligase activity
GO:0047481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanine:membrane-acceptor ligase activity
GO:0047481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl-poly(phosphoglycerol) synthetase activity
GO:0047481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity
GO:0047481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanylalanylpoly(phosphoglycerol) synthetase activity
RHEA:14128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 raffinose <=> 1(F)-alpha-D-galactosylraffinose + sucrose
REACT:R-RNO-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
RHEA:13324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3,3-dimethylmalate + NAD(+) <=> 3-methyl-2-oxobutanoate + CO2 + NADH
REACT:R-SPO-3000449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Schizosaccharomyces pombe)
REACT:R-MMU-352191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A8-mediated uptake of neutral amino acids (Mus musculus)
GO:0031806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metabotropic histamine receptor binding
GO:0031806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled histamine receptor binding
GO:0031806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled histamine receptor binding
GO:0031806	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metabotropic histamine receptor ligand
REACT:R-DRE-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Danio rerio)
REACT:R-DME-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Drosophila melanogaster)
REACT:R-BTA-174706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Bos taurus)
RHEA:56477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
RHEA:21882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + H2O2 => 2 H(+) + O2 + oxalate
RHEA:30866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-L-tyrosine + H2O <=> L-tyrosine + phosphate
REACT:R-DRE-5654623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS3 (Danio rerio)
REACT:R-BTA-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
RHEA:22506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate
RHEA:46732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,6)-dimethylheptanoyl-CoA = (2S,6)-dimethylheptanoyl-CoA
REACT:R-GGA-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Gallus gallus)
REACT:R-RNO-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Rattus norvegicus)
RHEA:35984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-DME-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Drosophila melanogaster)
REACT:R-DDI-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)
REACT:R-HSA-2564826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold (Homo sapiens)
REACT:R-PFA-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Plasmodium falciparum)
RHEA:72657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+) => 1-hydroxy-6-methoxyphenazine + NADPH + O2
REACT:R-CEL-8876484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 transfers CHOL to NPC1 (Caenorhabditis elegans)
RHEA:19433	skos:altLabel	"gluconate kinase"
RHEA:19433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)
RHEA:19433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gluconokinase"
RHEA:19433	skos:prefLabel	"gluconokinase"
REACT:R-SCE-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Saccharomyces cerevisiae)
REACT:R-CEL-188979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Caenorhabditis elegans)
REACT:R-MMU-450387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds the CRM1 nuclear export machinery (Mus musculus)
REACT:R-XTR-975311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Xenopus tropicalis)
RHEA:26555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin II + H2O => angiotensin-(1-7) + L-phenylalanine
REACT:R-HSA-2201338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds TICAM1:activated TLR4 complex (Homo sapiens)
REACT:R-XTR-5696220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to arsenite(3-) (Xenopus tropicalis)
REACT:R-GGA-421457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial uptake and processing of ALAS2 (Gallus gallus)
RHEA:42207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + NAD(+) <=> 11-dehydrocorticosterone + H(+) + NADH
RHEA:45773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannosyl](n) + phosphate => [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate
REACT:R-HSA-8865320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX1 (Homo sapiens)
RHEA:37521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:18799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-8936584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)
REACT:R-RNO-9679029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds HCQ (Rattus norvegicus)
GO:0070612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AR3 methyltransferase activity
GO:0070612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H2A-R3 specific)
GO:0070612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity (H2A-R3 specific)
GO:0070612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H2AR3 methyltransferase activity
GO:0070612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine N-methyltransferase activity (H2A-R3 specific)
GO:0070612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AR3 arginine methyltransferase activity
REACT:R-GGA-8852874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 binds C3d, C3dg, iC3b (Gallus gallus)
EC:1.1.1.343	skos:altLabel	"6-PGDH"
EC:1.1.1.343	skos:prefLabel	"phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating)"
EC:1.1.1.343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating)"
RHEA:10030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H2O2 + NH4(+) => D-glutamate + H2O + O2
REACT:R-DRE-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Danio rerio)
RHEA:70550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP
REACT:R-HSA-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Homo sapiens)
RHEA:44610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine
REACT:R-DRE-947535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Danio rerio)
REACT:R-XTR-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Xenopus tropicalis)
RHEA:25736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:17292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 2,6-bisphosphate + H2O <=> beta-D-fructose 6-phosphate + phosphate
GO:0015093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferrous iron transmembrane transporter activity
GO:0015093	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferrous iron uptake transmembrane transporter activity
REACT:R-MMU-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Mus musculus)
REACT:R-HSA-5665761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL3 binds RHOC:GTP (Homo sapiens)
RHEA:25109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate
RHEA:43314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate => ATP + N-(hexanoyl)sphing-4-enine
REACT:R-DME-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Drosophila melanogaster)
RHEA:64190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + L-tyrosine => an N-(fatty acyl)-L-tyrosine + H2O
REACT:R-RNO-9669893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type I TKIs (Rattus norvegicus)
RHEA:58934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+) => 4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH
RHEA:61429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-trans-nepetalactol + NAD(+) => cis-trans-nepetalactone + H(+) + NADH
REACT:R-RNO-5618328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAT acetylates microtubules (Rattus norvegicus)
RHEA:56250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein] => 1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]
RHEA:15352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + N(2)-acetyl-L-ornithine <=> L-ornithine + N-acetyl-L-glutamate
REACT:R-DRE-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Danio rerio)
REACT:R-CFA-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Canis familiaris)
REACT:R-CFA-5618085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Canis familiaris)
RHEA:54307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate <=> n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)
RHEA:10271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate
RHEA:19727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + UDP-beta-L-arabinopyranose => H(+) + UDP-alpha-D-galacturonate
REACT:R-MMU-8956639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds YAP1 (Mus musculus)
RHEA:62334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3'-diphosphate,5'-diphosphate + AMP => ADP + ATP
REACT:R-HSA-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Homo sapiens)
REACT:R-XTR-2046239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular KSPG translocates to the lysosome for degradation (Xenopus tropicalis)
REACT:R-BTA-5696021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPGK:Mg2+ phosphorylates Glc to G6P (Bos taurus)
REACT:R-SSC-9724745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds aprotinin (Sus scrofa)
RHEA:39057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:48416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) = CMP + ganglioside GM2 (d18:1(4E)) + H(+)
REACT:R-BTA-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)
REACT:R-CFA-378952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin is a heterodimer (Canis familiaris)
REACT:R-HSA-3318576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MMACHC does not reduce Cbl (Homo sapiens)
REACT:R-HSA-2262775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
RHEA:23228	skos:altLabel	"lysine N(6)-hydroxylase"
RHEA:23228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)
RHEA:23228	skos:prefLabel	"L-lysine N(6)-monooxygenase (NADPH)"
RHEA:23228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-lysine N(6)-monooxygenase (NADPH)"
REACT:R-RNO-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Rattus norvegicus)
REACT:R-CFA-2562526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates OPTN (Canis familiaris)
REACT:R-SCE-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)
RHEA:13549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-fucose 1-phosphate + GTP + H(+) = diphosphate + GDP-beta-L-fucose
RHEA:13549	skos:altLabel	"GDP-fucose pyrophosphorylase"
RHEA:13549	skos:altLabel	"GDP-fucose diphosphorylase"
RHEA:13549	skos:prefLabel	"fucose-1-phosphate guanylyltransferase"
RHEA:13549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fucose-1-phosphate guanylyltransferase"
RHEA:58516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-1112727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serine phosphorylation of STATs (Mus musculus)
REACT:R-HSA-1676174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Homo sapiens)
REACT:R-XTR-210283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and PLC gamma1 (Xenopus tropicalis)
REACT:R-SCE-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Saccharomyces cerevisiae)
RHEA:18886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
REACT:R-SSC-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Sus scrofa)
REACT:R-CEL-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Caenorhabditis elegans)
REACT:R-DRE-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
REACT:R-GGA-8855747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Gallus gallus)
RHEA:48923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Gallus gallus)
RHEA:38897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in)
REACT:R-MMU-8948228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Mus musculus)
REACT:R-BTA-2396561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)
REACT:R-MMU-9028730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FRS2 (Mus musculus)
REACT:R-HSA-375141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neogenin:Netrin-3 binds CDO complex (Homo sapiens)
REACT:R-CFA-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)
REACT:R-HSA-9007591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds RRM2 gene promoter (Homo sapiens)
RHEA:35955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryprostatin B 6-hydroxylase"
RHEA:35955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B = 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35955	skos:prefLabel	"tryprostatin B 6-hydroxylase"
RHEA:18618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + oxaloacetate => ADP + CO2 + phosphoenolpyruvate
GO:0050420	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)
GO:0050420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose synthase activity
RHEA:45337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA
RHEA:12141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside + ATP => a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)
REACT:R-SSC-2685505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPCN1/2 transport lysosomal Ca2+ to cytosol  (Sus scrofa)
REACT:R-RNO-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Rattus norvegicus)
RHEA:66046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + H2O + kynurenate => 2-oxobutanoate + L-kynurenine
REACT:R-CFA-381262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPARG:RXRA heterodimer (ARF6 complex) (Canis familiaris)
RHEA:47810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Gallus gallus)
RHEA:46942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate => AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein]
REACT:R-DME-5607731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)
RHEA:45190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-XTR-2473151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister centromeres (Xenopus tropicalis)
REACT:R-RNO-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Rattus norvegicus)
REACT:R-HSA-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Homo sapiens)
RHEA:57599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:15479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5beta-scymnol
RHEA:53459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)
RHEA:15905	skos:prefLabel	"3-hydroxycyclohexanone dehydrogenase"
RHEA:15905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxycyclohexanone dehydrogenase"
RHEA:15905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxycyclohexanone + A = AH2 + cyclohexane-1,3-dione
RHEA:68912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + propanoate = AMP + diphosphate + NADP(+) + propanal
REACT:R-HSA-75083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)
RHEA:70674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]
REACT:R-GGA-8851352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR8 binds CCL1 (Gallus gallus)
REACT:R-PFA-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Plasmodium falciparum)
REACT:R-CFA-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)
REACT:R-HSA-9664268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsonized leishmania amastigote binds FCGR3 (Homo sapiens)
RHEA:21230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-maltose => alpha-maltose
RHEA:28460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin(out) => biotin(in)
REACT:R-SPO-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Schizosaccharomyces pombe)
REACT:R-MMU-8987014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Mus musculus)
REACT:R-CFA-879909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of STAT5a/b by JAK2 (Canis familiaris)
RHEA:58873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:20159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+) => a polyvinyl alcohol + 2n Fe(III)-[cytochrome c]
REACT:R-RNO-74715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of insulin receptor (Rattus norvegicus)
REACT:R-BTA-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Bos taurus)
REACT:R-RNO-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-SSC-68918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
REACT:R-HSA-9013108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOC (Homo sapiens)
REACT:R-DRE-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Danio rerio)
REACT:R-HSA-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
REACT:R-MMU-9696323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNRs bind CNR agonists (Mus musculus)
REACT:R-BTA-373071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR7 binds CCL19 and 21 ligands (Bos taurus)
GO:0031218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinogalactanase activity
GO:0031218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactanase activity
GO:0031218	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arabinogalactan 4-beta-D-galactanohydrolase activity
GO:0031218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-1,4-beta-galactanase activity
GO:0031218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinogalactan endo-1,4-beta-galactosidase activity
RHEA:54188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-phenylalanine = acetate + L-phenylalanine
RHEA:28811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxo-L-gulonate(in) + Na(+)(in) = 2,3-dioxo-L-gulonate(out) + Na(+)(out)
EC:3.5.1.133	skos:altLabel	"axillary malodor releasing enzyme"
EC:3.5.1.133	skos:prefLabel	"N(alpha)-acyl-L-glutamine aminoacylase"
EC:3.5.1.133	skos:altLabel	"AMRE"
EC:3.5.1.133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(alpha)-acyl-L-glutamine aminoacylase"
RHEA:53668	skos:prefLabel	"(1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase"
RHEA:53668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase"
RHEA:53668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
RHEA:50632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O
RHEA:36962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribono-1,4-lactone + H(+) + NADH <=> D-ribose + NAD(+)
REACT:R-MMU-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Mus musculus)
RHEA:69421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + iodide => H2O + hypoiodite
REACT:R-HSA-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Homo sapiens)
REACT:R-DRE-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)
REACT:R-DDI-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)
GO:0016732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor
GO:0016732	skos:prefLabel	"With dinitrogen as acceptor"
GO:0016732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With dinitrogen as acceptor"
GO:0055105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-protein transferase inhibitor activity
RHEA:55136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanine + H(+) = D-alanyl-5'-AMP + diphosphate
GO:0009039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urease activity
GO:0009039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urea amidohydrolase activity
REACT:R-DRE-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Danio rerio)
RHEA:25276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate
REACT:R-MMU-428534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Profilin by Ena/VASP proteins (Mus musculus)
REACT:R-RNO-5357429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL autophosphorylates on Y772 and Y814 (Rattus norvegicus)
REACT:R-XTR-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)
REACT:R-DRE-266089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Discoidal HDL binds membrane-associated free cholesterol (Danio rerio)
REACT:R-SSC-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Sus scrofa)
RHEA:48502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + octanoate => H2O + octanoylglycerol
RHEA:30055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine + NADP(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADPH
REACT:R-BTA-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
RHEA:50236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Canis familiaris)
RHEA:60055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)
REACT:R-XTR-1474158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCHFR binds to GCH1 and negatively regulates its activity (Xenopus tropicalis)
REACT:R-BTA-264689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Bos taurus)
RHEA:15466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + sphinganine => ADP + H(+) + sphinganine 1-phosphate
RHEA:30618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 2 A <=> 2 AH2 + all-trans-zeta-carotene
REACT:R-DRE-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Danio rerio)
RHEA:37540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-SCE-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Saccharomyces cerevisiae)
REACT:R-CFA-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Canis familiaris)
REACT:R-MMU-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Mus musculus)
REACT:R-XTR-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Xenopus tropicalis)
RHEA:60698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lavandulol + diphosphate => (R)-lavandulyl diphosphate + H2O
RHEA:60058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+) => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2
RHEA:31873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-seco-amyrin => (S)-2,3-epoxysqualene
RHEA:67044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + asnovolin H = AH2 + chermesin D
GO:0018753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanuric acid amidohydrolase activity
REACT:R-RNO-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Rattus norvegicus)
REACT:R-RNO-450325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-FOS activation by phospho ERK1/2 (Rattus norvegicus)
GO:0051981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copper chelate transmembrane transporter activity
REACT:R-DRE-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Danio rerio)
REACT:R-XTR-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Xenopus tropicalis)
REACT:R-DRE-1971483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Danio rerio)
RHEA:17376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin <=> all-trans-capsanthin
REACT:R-HSA-2066785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retranslocation of DHA back to ER (Homo sapiens)
REACT:R-RNO-380294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of C-Nap-1 from centrosomes (Rattus norvegicus)
RHEA:48814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2
REACT:R-BTA-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Bos taurus)
REACT:R-DME-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Drosophila melanogaster)
REACT:R-CFA-5649801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Canis familiaris)
GO:0106229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone glutaryltransferase activity
RHEA:65790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:64091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA <=> 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O
REACT:R-DME-190258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c binds to FGF (Drosophila melanogaster)
REACT:R-CFA-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Canis familiaris)
RHEA:43224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-RNO-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Rattus norvegicus)
REACT:R-BTA-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Bos taurus)
REACT:R-MMU-159757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)
REACT:R-CFA-5683425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53BP1 at DNA DSBs (Canis familiaris)
REACT:R-GGA-201629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Tau (Gallus gallus)
REACT:R-SSC-9793680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPTN binds polyUb-RIPK1 within the TNFR1 complex (Sus scrofa)
REACT:R-SPO-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Schizosaccharomyces pombe)
REACT:R-HSA-9636396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lpdC binds to CORO1A (Homo sapiens)
REACT:R-SSC-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Sus scrofa)
REACT:R-RNO-140806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINC1 binds SERPINC1 activators (Rattus norvegicus)
RHEA:44799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-13 + S-adenosyl-L-methionine <=> H(+) + menaquinol-13 + S-adenosyl-L-homocysteine
REACT:R-HSA-9665388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)
REACT:R-MMU-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Mus musculus)
REACT:R-GGA-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Gallus gallus)
REACT:R-MMU-191983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)
GO:0044600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein guanylyltransferase activity
RHEA:49880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:29329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + succinate(in) => (S)-malate(in) + succinate(out)
RHEA:49549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => H(+) + L-arginyl-[protein] + lactate
RHEA:71088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) => 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)
REACT:R-BTA-4551724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 (Bos taurus)
GO:0004909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1 activating receptor activity
GO:0004909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-1 type I, activating binding
GO:0004909	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	interleukin-1, type I, activating binding
GO:0004909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1, type I, activating receptor activity
GO:0004909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-1 type I, activating receptor
GO:0004909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1 type I receptor activity
REACT:R-DRE-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Danio rerio)
REACT:R-MMU-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Mus musculus)
RHEA:61937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cycloheximide(in) + H2O => ADP + cycloheximide(out) + H(+) + phosphate
REACT:R-DME-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Drosophila melanogaster)
RHEA:19582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-dimethylallyladenine + S-adenosyl-L-methionine => discadenine + H(+) + S-methyl-5'-thioadenosine
RHEA:57804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-3-nitrobenzene + NADH + O2 = 4-chlorocatechol + NAD(+) + nitrite
REACT:R-DME-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Drosophila melanogaster)
RHEA:44187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate <=> 2-epi-5-epi-valiolone + phosphate
REACT:R-DRE-8874204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3 (Danio rerio)
REACT:R-SSC-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Sus scrofa)
RHEA:31023	skos:prefLabel	"dammaradiene synthase"
RHEA:31023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene = dammara-20,24-diene
RHEA:31023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dammaradiene synthase"
REACT:R-HSA-2730856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Homo sapiens)
RHEA:48521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol
RHEA:59237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + isoelisabethatriene
REACT:R-XTR-1678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses CS/HS precursor (Xenopus tropicalis)
REACT:R-BTA-9762345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDN:ALB dissociates (Bos taurus)
RHEA:17172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-D-galactosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate
RHEA:14657	skos:prefLabel	"ribose-5-phosphate isomerase"
RHEA:14657	skos:altLabel	"5-phosphoribose isomerase"
RHEA:14657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate
RHEA:14657	skos:altLabel	"ribose 5-phosphate epimerase"
RHEA:14657	skos:altLabel	"phosphopentosisomerase"
RHEA:14657	skos:altLabel	"D-ribose-5-phosphate ketol-isomerase"
RHEA:14657	skos:altLabel	"phosphoriboisomerase"
RHEA:14657	skos:altLabel	"phosphopentoseisomerase"
RHEA:14657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribose-5-phosphate isomerase"
RHEA:14657	skos:altLabel	"ribose phosphate isomerase"
REACT:R-RNO-73932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resynthesis of excised residue by POLB (Rattus norvegicus)
REACT:R-BTA-111742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)
REACT:R-RNO-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Rattus norvegicus)
REACT:R-CFA-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Canis familiaris)
RHEA:70894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(out) + L-glutamine(in) + Na(+)(out) <=> L-asparagine(in) + L-glutamine(out) + Na(+)(in)
REACT:R-XTR-4085296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NCOA1 with SUMO1 (Xenopus tropicalis)
RHEA:27457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH
REACT:R-GGA-1433395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of sSCF (Gallus gallus)
RHEA:51269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norbelladine + S-adenosyl-L-methionine => 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-9009308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 polyubiquitinates RUNX2 (Drosophila melanogaster)
REACT:R-MMU-2176491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L binds phosphorylated linker region of SMAD2/3 (Mus musculus)
REACT:R-SSC-1237059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ dehydrates HCO3- to CO2 (Sus scrofa)
REACT:R-HSA-379993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)
REACT:R-DME-209100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYD88:TUB binds to TL receptor (Drosophila melanogaster)
REACT:R-CFA-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Canis familiaris)
REACT:R-CEL-8848864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARAP1 (Caenorhabditis elegans)
REACT:R-PFA-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Plasmodium falciparum)
REACT:R-GGA-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Gallus gallus)
REACT:R-CFA-77274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Canis familiaris)
REACT:R-CFA-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)
REACT:R-PFA-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Plasmodium falciparum)
RHEA:43292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
REACT:R-SCE-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Saccharomyces cerevisiae)
REACT:R-GGA-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Gallus gallus)
REACT:R-SPO-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Schizosaccharomyces pombe)
REACT:R-BTA-1112755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds IL6ST (Bos taurus)
RHEA:71214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorate(out) + 2 Na(+)(out) <=> chlorate(in) + 2 Na(+)(in)
REACT:R-CEL-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Caenorhabditis elegans)
REACT:R-CFA-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Canis familiaris)
REACT:R-CFA-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Canis familiaris)
REACT:R-DRE-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Danio rerio)
REACT:R-SSC-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Sus scrofa)
REACT:R-XTR-5696197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Xenopus tropicalis)
REACT:R-XTR-9605644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Xenopus tropicalis)
REACT:R-SSC-9606887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CD19:VAV binds PI3K and GRB2 (Sus scrofa)
RHEA:61732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviol + UDP-alpha-D-glucose = H(+) + steviolmonoside + UDP
REACT:R-MMU-2129357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin C-terminal processing (Mus musculus)
REACT:R-SSC-8940134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 binds FOLA (Sus scrofa)
REACT:R-PFA-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Plasmodium falciparum)
GO:0034950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylboronic acid monooxygenase activity
RHEA:31282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate
REACT:R-HSA-378956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone is a heterodimer (Homo sapiens)
RHEA:58025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleanolate + UDP-alpha-D-glucose => H(+) + oleanolate 3-O-beta-D-glucoside + UDP
REACT:R-GGA-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Gallus gallus)
RHEA:25884	skos:altLabel	"N-succinyl-L-ornithine transcarbamylase"
RHEA:25884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate
RHEA:25884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-succinylornithine carbamoyltransferase"
RHEA:25884	skos:prefLabel	"N-succinylornithine carbamoyltransferase"
RHEA:25884	skos:altLabel	"succinylornithine transcarbamylase"
RHEA:25884	skos:altLabel	"SOTCase"
REACT:R-XTR-977371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates Factor H-boundC3b (Xenopus tropicalis)
REACT:R-HSA-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Homo sapiens)
REACT:R-RNO-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Rattus norvegicus)
GO:0033867	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK10
GO:0033867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fas-activated serine/threonine kinase activity
GO:0033867	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:Fas-activated serine/threonine protein phosphotransferase activity
GO:0033867	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAST
GO:0033867	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FASTK
REACT:R-XTR-3002811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates PLK1 (Xenopus tropicalis)
REACT:R-BTA-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Bos taurus)
REACT:R-HSA-9662786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN cleaves ADAM17 (Homo sapiens)
REACT:R-HSA-1855200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Homo sapiens)
RHEA:64830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-benzyl acetate + CoA => 3-hydroxybenzyl alcohol + acetyl-CoA
RHEA:68465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-butyloctyl sulfate + H2O => 2-butyloctan-1-ol + H(+) + sulfate
REACT:R-BTA-8867044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EPS15, EPN1, EPS15L1 (Bos taurus)
REACT:R-HSA-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Homo sapiens)
RHEA:34506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epi-alpha-bisabolol + diphosphate
REACT:R-RNO-204981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3epsilon attentuates NADE-related apoptosis (Rattus norvegicus)
REACT:R-SSC-8866329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP lipidates APOB-100, forming a pre-VLDL (Sus scrofa)
REACT:R-XTR-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Xenopus tropicalis)
REACT:R-CFA-1474266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibrils (Canis familiaris)
REACT:R-DDI-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Dictyostelium discoideum)
RHEA:36952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 => (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-XTR-5218642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Xenopus tropicalis)
RHEA:61512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malvidin + UDP-alpha-D-glucose = malvidin 3-O-beta-D-glucoside + UDP
REACT:R-HSA-264834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis and degradation of apoA-I (Homo sapiens)
REACT:R-CEL-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Caenorhabditis elegans)
REACT:R-MMU-8848726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates BCAR1 (Mus musculus)
REACT:R-BTA-195418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-2 associates with VEGFR1 forming complexes on  cell surface (Bos taurus)
REACT:R-XTR-210294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-2 (Xenopus tropicalis)
RHEA:16367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3,4,5-trihydroxybenzoate + H(+) => digallate + H2O
GO:0008885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity
GO:0008885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:spermidine ligase (ADP-forming) activity
GO:0008885	skos:altLabel	"gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming)"
GO:0008885	skos:altLabel	"GSP synthetase"
GO:0008885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]
GO:0008885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathionylspermidine synthase"
GO:0008885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathionylspermidine synthetase activity
GO:0008885	skos:altLabel	"glutathionylspermidine synthetase"
GO:0008885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GSP synthetase activity
GO:0008885	skos:altLabel	"glutathione:spermidine ligase (ADP-forming)"
GO:0008885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathionylspermidine synthase activity
GO:0008885	skos:prefLabel	"glutathionylspermidine synthase"
REACT:R-MMU-170844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 is cleaved by FURIN (Mus musculus)
GO:0045503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynein light chain binding
RHEA:19732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + H(+) <=> acetone + CO2
REACT:R-MMU-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)
REACT:R-XTR-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Xenopus tropicalis)
RHEA:52019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate
RHEA:42772	skos:prefLabel	"16S rRNA (guanine(1405)-N(7))-methyltransferase"
RHEA:42772	skos:altLabel	"sisomicin-gentamicin methyltransferase"
RHEA:42772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:42772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (guanine(1405)-N(7))-methyltransferase"
REACT:R-HSA-8851888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds SHC1-2 (Homo sapiens)
REACT:R-DRE-68954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm2-7 is phosphorylated by DDK (Danio rerio)
RHEA:20947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + theobromine <=> caffeine + H(+) + S-adenosyl-L-homocysteine
RHEA:52943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + UDP-alpha-D-glucuronate <=> chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP
RHEA:59300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + firefly D-luciferin = adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)
RHEA:29595	skos:prefLabel	"sulfoacetaldehyde dehydrogenase (acylating)"
RHEA:29595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfoacetaldehyde dehydrogenase (acylating)"
RHEA:29595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NADP(+) + sulfoacetaldehyde = H(+) + NADPH + sulfoacetyl-CoA
REACT:R-BTA-9620515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2B,EP300 acetylate FOXO3 under oxidative stress (Bos taurus)
RHEA:44725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-saturated fatty aldehyde + NADP(+) => (2E)-fatty aldehyde + H(+) + NADPH
GO:0005547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binding
REACT:R-XTR-8938815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 polyubiquitinates RRAGA (Xenopus tropicalis)
REACT:R-DRE-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Danio rerio)
REACT:R-MMU-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Mus musculus)
REACT:R-DRE-2129385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFAP2, MFAP5 bind microfibrils (Danio rerio)
GO:0004803	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P-element encoded transposase activity
GO:0004803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transposase activity
REACT:R-RNO-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Rattus norvegicus)
RHEA:37798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADPH + O2 <=> 2 H2O + 2 NADP(+)
RHEA:47968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 + H2O = ganglioside GM3 + N-acetyl-beta-D-galactosamine
RHEA:13639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methanol + NAD(+) => H(+) + methane + NADH + O2
RHEA:36536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + sphinganine => CoA + H(+) + N-docosanoylsphinganine
REACT:R-CFA-9603420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 promotes SRC autophosphorylation (Canis familiaris)
REACT:R-SSC-202245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TBSMs in LAT (Sus scrofa)
REACT:R-MMU-4754181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me2K5-histone H3 (Mus musculus)
GO:0045236	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CXC chemokine receptor ligand
GO:0045236	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha chemokine receptor ligand
GO:0045236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR chemokine receptor binding
GO:0045236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha chemokine receptor binding
GO:0045236	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	C-X-C chemokine receptor ligand
REACT:R-MMU-8985594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYO9B inactivates RHOA (Mus musculus)
RHEA:30741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + phosphate => 1D-myo-inositol 3-phosphate + H2O
REACT:R-CFA-9011543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCA binds PDK2 (Canis familiaris)
REACT:R-RNO-418918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The UDP/CysLT (P2Y17) receptor can bind UTP (Rattus norvegicus)
RHEA:51946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine
REACT:R-SSC-5654165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR1 (Sus scrofa)
REACT:R-GGA-2990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO1 to UBA2:SAE1 (Gallus gallus)
RHEA:13234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine
RHEA:35855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-DRE-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Danio rerio)
REACT:R-SSC-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Sus scrofa)
REACT:R-BTA-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Bos taurus)
GO:1990757	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitotic anaphase-promoting complex activator activity
GO:1990757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin ligase activator activity
REACT:R-CFA-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Canis familiaris)
REACT:R-RNO-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Rattus norvegicus)
REACT:R-DRE-193508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Danio rerio)
RHEA:45448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(dodecanoyl)-sphinganine = dodecanoate + sphinganine
REACT:R-DRE-5686286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Danio rerio)
RHEA:52443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose <=> a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)
GO:0008829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidine triphosphate deaminase activity
GO:0008829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP deaminase activity
GO:0008829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyl-dCTP deaminase activity
GO:0008829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dCTP aminohydrolase activity
REACT:R-DRE-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)
RHEA:16758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + trypanothione => H(+) + NADPH + trypanothione disulfide
RHEA:44173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + tetradecanal => 2 H(+) + NADH + tetradecanoate
RHEA:54520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = cycloaraneosene + diphosphate
RHEA:54520	skos:prefLabel	"cycloaraneosene synthase"
RHEA:54520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cycloaraneosene synthase"
REACT:R-DRE-9755306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub UBXN7 is degraded by the 26S proteasome (Danio rerio)
REACT:R-DRE-6797974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRTMs bind NRXNs (Danio rerio)
REACT:R-SCE-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Saccharomyces cerevisiae)
GO:0018500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity
GO:0140488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme receptor activity
RHEA:47017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O => [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite
RHEA:11871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NADP(+) <=> D-ribulose + H(+) + NADPH
RHEA:47783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 25S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:23046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tyrosine
REACT:R-SSC-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Sus scrofa)
RHEA:23309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + D-glucarate => 2-O-[(E)-sinapoyl]-D-glucarate + CoA
REACT:R-SPO-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Schizosaccharomyces pombe)
REACT:R-RNO-8851842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUC20 binds MET and inhibits GRB2 binding (Rattus norvegicus)
RHEA:38585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O
REACT:R-RNO-5675456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer (Rattus norvegicus)
REACT:R-HSA-1169188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 (PTPN6) dephosphorylates JAK2 (Homo sapiens)
REACT:R-MMU-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Mus musculus)
RHEA:39945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + CoA => a 1-acylglycerol + an acyl-CoA
REACT:R-GGA-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Gallus gallus)
REACT:R-DRE-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Danio rerio)
REACT:R-CFA-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Canis familiaris)
REACT:R-MMU-8953917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Mus musculus)
RHEA:39999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid 1-phosphate = a fatty aldehyde + phosphoethanolamine
RHEA:23772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH
RHEA:23772	skos:prefLabel	"2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase"
RHEA:23772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase"
RHEA:23772	skos:altLabel	"biphenyl-2,3-dihydro-2,3-diol dehydrogenase"
GO:0099583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:0099583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
REACT:R-CFA-3662335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates histone H2A, H2B, H3, H4 (Canis familiaris)
REACT:R-RNO-8849032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS2 (Rattus norvegicus)
RHEA:30434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> taraxerol
GO:0052790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In linear amides"
GO:0052790	skos:prefLabel	"In linear amides"
GO:0052790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitooligosaccharide deacetylase activity
REACT:R-SCE-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Saccharomyces cerevisiae)
REACT:R-SPO-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Schizosaccharomyces pombe)
RHEA:22882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + prephenate => 2-oxoglutarate + L-arogenate
RHEA:43583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-arginine <=> AH2 + iminoarginine
RHEA:53271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose <=> L-xylulose
REACT:R-CFA-187895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal C-ter TLR9 (Canis familiaris)
REACT:R-GGA-2028583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS2 (Gallus gallus)
RHEA:18593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate = hexadecanal + phosphoethanolamine
RHEA:58610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-decanoylglycine + O2
RHEA:16678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetaldehyde + H2O + NAD(+) => fluoroacetate + 2 H(+) + NADH
GO:0033727	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AORDd
GO:0033727	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mop
GO:0033727	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde:acceptor oxidoreductase (FAD-independent) activity
GO:0033727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde dehydrogenase (FAD-independent) activity
GO:0033727	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde oxidoreductase activity
REACT:R-HSA-9609274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds HCK (Homo sapiens)
GO:0052754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:coenzyme F420 guanyltransferase activity
GO:0052754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:coenzyme F420 guanylyltransferase activity
GO:0052754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F390-G synthetase activity
RHEA:43902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+) => dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O
REACT:R-MMU-8876484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 transfers CHOL to NPC1 (Mus musculus)
RHEA:56599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-bornane-2,5-dione + FMNH2 + O2 <=> (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O
RHEA:68081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O => a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)
RHEA:35179	skos:prefLabel	"noranthrone synthase"
RHEA:35179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA = 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone
RHEA:35179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"noranthrone synthase"
RHEA:35179	skos:altLabel	"polyketide synthase A"
RHEA:35179	skos:altLabel	"norsolorinic acid anthrone synthase"
GO:0033908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-L-rhamnoside rhamnohydrolase activity
GO:0033908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-rhamnosidase activity
REACT:R-GGA-8952382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 polyubiquitinates RUNX3 (Gallus gallus)
REACT:R-MMU-9011748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R binds JAK1 (Mus musculus)
REACT:R-CFA-9668395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CC2D1B (Canis familiaris)
REACT:R-HSA-5656219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC4A4 does not cotransport Na+ with 3HCO3- (Homo sapiens)
RHEA:35264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
REACT:R-HSA-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Homo sapiens)
GO:0034318	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	AEATase activity
GO:0034318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol acyltransferase activity
GO:0034318	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acyl-CoA:ethanol O-acyltransferase
GO:0034318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol O-acyltransferase activity
GO:0034318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA:alcohol O-acyltransferase activity
GO:0034318	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acyl-coenzymeA:ethanol O-acyltransferase activity
GO:0034318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-coenzymeA:alcohol O-acyltransferase activity
REACT:R-HSA-2168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds DLL4 (Homo sapiens)
REACT:R-CEL-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Caenorhabditis elegans)
RHEA:55778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP => all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate
RHEA:21605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	styrene oxide => 2-phenylacetaldehyde
RHEA:66665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + coproporphyrin III(in) + H2O => ADP + coproporphyrin III(out) + H(+) + phosphate
REACT:R-HSA-449818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL13 binds IL13RA2 (Homo sapiens)
RHEA:14562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-piperoyl-CoA + piperidine => CoA + H(+) + N-[(E,E)-piperoyl]piperidine
REACT:R-DRE-2022398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Danio rerio)
RHEA:33245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Danio rerio)
GO:0090440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisic acid transmembrane transporter activity
GO:0090440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisic acid transporter activity
REACT:R-BTA-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Bos taurus)
REACT:R-DDI-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Dictyostelium discoideum)
REACT:R-SSC-1028821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Phospho IRF3 or phospho IRF7 (Sus scrofa)
REACT:R-SSC-8948066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-IRAK1 dissociates (Sus scrofa)
REACT:R-XTR-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Xenopus tropicalis)
RHEA:21929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + NADP(+) => 2,3-dioxo-L-gulonate + H(+) + NADPH
RHEA:55497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Danio rerio)
REACT:R-CFA-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Canis familiaris)
REACT:R-BTA-5696872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates Ub-MOM proteins (Bos taurus)
REACT:R-HSA-9704692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 7a binds BCL2L1 (Homo sapiens)
REACT:R-CEL-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Caenorhabditis elegans)
EC:2.3.1.304	skos:altLabel	"PHA synthase"
EC:2.3.1.304	skos:prefLabel	"poly[(R)-3-hydroxyalkanoate] polymerase"
EC:2.3.1.304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"poly[(R)-3-hydroxyalkanoate] polymerase"
RHEA:45943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA
EC:3.1.11.2	skos:altLabel	"exonuclease III"
EC:3.1.11.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exodeoxyribonuclease III"
EC:3.1.11.2	skos:altLabel	"E.coli exonuclease III"
EC:3.1.11.2	skos:prefLabel	"exodeoxyribonuclease III"
GO:0047229	skos:prefLabel	"13-hydroxydocosanoate 13-beta-glucosyltransferase"
GO:0047229	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity
GO:0047229	skos:altLabel	"13-glucosyloxydocosanoate 2'-beta-glucosyltransferase"
GO:0047229	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity
GO:0047229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxydocosanoate 13-beta-glucosyltransferase activity
GO:0047229	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity
GO:0047229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxydocosanoate + UDP-alpha-D-glucose = 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP
GO:0047229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"13-hydroxydocosanoate 13-beta-glucosyltransferase"
GO:0047229	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity
GO:0047229	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity
GO:0047229	skos:altLabel	"UDP-glucose-13-hydroxydocosanoate glucosyltransferase"
GO:0047229	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity
RHEA:45658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+)
RHEA:34576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone
RHEA:34202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> bracteatin 6-O-beta-glucoside + H2O
REACT:R-MMU-5675206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEA15 binds MAPK monomers and dimers (Mus musculus)
RHEA:32242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-carotene <=> all-trans-beta-carotene
RHEA:34613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP => N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose
RHEA:61299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-alpha-D-ribose 1-phosphate <=> 5-deoxy-D-ribulose 1-phosphate
REACT:R-CFA-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)
REACT:R-BTA-171141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Bos taurus)
REACT:R-SSC-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Sus scrofa)
EC:1.14.11.21	skos:altLabel	"clavaminic acid synthase"
EC:1.14.11.21	skos:prefLabel	"clavaminate synthase"
EC:1.14.11.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"clavaminate synthase"
RHEA:50302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-CFA-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Canis familiaris)
REACT:R-HSA-9667809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region (Homo sapiens)
REACT:R-XTR-374758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Somatostatin receptors bind somatostatin and cortistatin (Xenopus tropicalis)
REACT:R-HSA-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Homo sapiens)
REACT:R-SPO-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Schizosaccharomyces pombe)
REACT:R-DDI-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Dictyostelium discoideum)
RHEA:44133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine
REACT:R-MMU-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Mus musculus)
RHEA:24566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxoacyl-CoA + succinate => a 3-oxo acid + succinyl-CoA
GO:0015501	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium/excitatory glutamate cotransporter activity
GO:0015501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + 2 Na(+)(in) = L-glutamate(out) + 2 Na(+)(out)
GO:0015501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate:sodium symporter activity
GO:0015501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/excitatory glutamate symporter activity
REACT:R-DME-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Drosophila melanogaster)
RHEA:46103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> cortisol + H2O + 2 oxidized [adrenodoxin]
REACT:R-MMU-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)
GO:0016169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacteriochlorophyll c binding
RHEA:39463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA = (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O
REACT:R-CEL-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Caenorhabditis elegans)
REACT:R-DDI-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Dictyostelium discoideum)
RHEA:22911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP + H(+) + H2O <=> 3',5'-cyclic IMP + NH4(+)
REACT:R-MMU-392752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by CK-II (Mus musculus)
REACT:R-GGA-2395223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyridinoline cross-links (Gallus gallus)
REACT:R-DME-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)
GO:0048249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity phosphate transmembrane transporter activity
GO:0048249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity phosphate transmembrane transporter activity
RHEA:30582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-threonine <=> L-threonine + phosphate
REACT:R-PFA-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Plasmodium falciparum)
REACT:R-HSA-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
RHEA:49122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + violaceinate => H(+) + NADPH + O2 + protoviolaceinate
RHEA:37841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA
RHEA:43004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-carbamoyl-L-serine = 2-aminoprop-2-enoate + CO2 + NH4(+)
RHEA:48535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GQ1c (d18:1(4E)) + H2O <=> ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate
RHEA:35024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone O-beta-D-glucopyranoside(out) => hydroquinone O-beta-D-glucopyranoside(in)
REACT:R-BTA-193099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)
GO:0016871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-epoxysqualene cycloartenol-cyclase activity
GO:0016871	skos:prefLabel	"cycloartenol synthase"
GO:0016871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-epoxysqualene--cycloartenol cyclase activity
GO:0016871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)
GO:0016871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cycloartenol synthase"
GO:0016871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidosqualene:cycloartenol cyclase activity
GO:0016871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-oxidosqualene-cycloartenol cyclase activity
GO:0016871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloartenol synthase activity
GO:0016871	skos:altLabel	"2,3-epoxysqualene--cycloartenol cyclase"
GO:0016871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = cycloartenol
GO:0016871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene-2,3-epoxide-cycloartenol cyclase activity
REACT:R-DDI-2872497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-2 transports cytosolic urate to extracellular region (Dictyostelium discoideum)
REACT:R-BTA-1855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Bos taurus)
REACT:R-GGA-198611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates IKKalpha (Gallus gallus)
RHEA:33220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Dictyostelium discoideum)
REACT:R-MMU-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Mus musculus)
REACT:R-SSC-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
RHEA:31119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O
RHEA:18654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	barbiturate + H2O => 3-oxo-3-ureidopropanoate
REACT:R-GGA-211923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26C1 4-hydroxylates 9cRA (Gallus gallus)
RHEA:54981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)
EC:3.6.1.41	skos:prefLabel	"bis(5'-nucleosyl)-tetraphosphatase (symmetrical)"
EC:3.6.1.41	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bis(5'-nucleosyl)-tetraphosphatase (symmetrical)"
EC:3.6.1.41	skos:altLabel	"diadenosinetetraphosphatase (symmetrical)"
EC:3.6.1.41	skos:altLabel	"Ap4A hydrolase"
EC:3.6.1.41	skos:altLabel	"diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase"
EC:3.6.1.41	skos:altLabel	"dinucleosidetetraphosphatase (symmetrical)"
REACT:R-BTA-5682629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Bos taurus)
RHEA:16694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene oxide => (Z)-2-methyl-5-isopropylhexa-2,5-dienal
RHEA:37371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP
RHEA:72216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + Na(+)(out) => 2 hydrogencarbonate(in) + Na(+)(in)
RHEA:36840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-XTR-191636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cx43 by c-src (Xenopus tropicalis)
RHEA:59824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + pyridoxamine 5'-phosphate = L-glutamate + pyridoxal 5'-phosphate
RHEA:59025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trihexadecanoylglycerol => dihexadecanoylglycerol + H(+) + hexadecanoate
REACT:R-CFA-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Canis familiaris)
REACT:R-XTR-2454240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-FCERI gamma subunit (Xenopus tropicalis)
RHEA:15440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + CoA + NADP(+) <=> a long-chain fatty acyl-CoA + H(+) + NADPH
REACT:R-DRE-2473152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Danio rerio)
RHEA:55979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + thiosulfate <=> H(+) + S-sulfanylglutathione + sulfite
REACT:R-MMU-5229203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 methylates histone H2A arginine-30 (H2AR29) (Mus musculus)
REACT:R-CFA-381644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER calcium channels open in response to activated PKA (Canis familiaris)
RHEA:46375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-8871370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Bos taurus)
REACT:R-RNO-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Rattus norvegicus)
REACT:R-HSA-111913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin binds CAMK4 (Homo sapiens)
RHEA:30965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,7',9,9'-tetra-cis-lycopene + a quinol => 7,9,9'-tri-cis-neurosporene + a quinone
REACT:R-HSA-349444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of COP1 at Ser-387  by ATM (Homo sapiens)
RHEA:59053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine + H(+) => cadaverine + CO2
GO:0046714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	boron binding
GO:0046714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	borate binding
REACT:R-MMU-9679028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 binds JAK3 inhibitors (Mus musculus)
REACT:R-SPO-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Schizosaccharomyces pombe)
REACT:R-DRE-3640874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-RibC-AXIN is degraded by the proteasome (Danio rerio)
REACT:R-RNO-8849428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 binds PTK6 (Rattus norvegicus)
RHEA:60352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-3-hydroxy-4(1H)-quinolone + O2 = CO + H(+) + N-octanoylanthranilate
EC:2.4.1.140	skos:prefLabel	"alternansucrase"
EC:2.4.1.140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alternansucrase"
EC:2.4.1.140	skos:altLabel	"sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase"
EC:2.4.1.140	skos:altLabel	"sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase"
REACT:R-HSA-9024586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AT-RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)
RHEA:71333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-phenylalanine(in) + 2 Na(+)(in) => chloride(out) + L-phenylalanine(out) + 2 Na(+)(out)
RHEA:24577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H2O => H(+) + 2 phosphate
REACT:R-GGA-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Gallus gallus)
REACT:R-CEL-1169399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Caenorhabditis elegans)
REACT:R-RNO-1236955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Movement of clathrin coated vesicles into early endosome (Rattus norvegicus)
RHEA:19463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP
REACT:R-HSA-5617182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates PLN (Homo sapiens)
REACT:R-BTA-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Bos taurus)
RHEA:40923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
RHEA:24556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase"
RHEA:24556	skos:prefLabel	"5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase"
RHEA:24556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH
REACT:R-XTR-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Xenopus tropicalis)
REACT:R-HSA-211191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF with alpha:beta importin (Homo sapiens)
REACT:R-HSA-6786205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Homo sapiens)
RHEA:65835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate
REACT:R-RNO-1638032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Rattus norvegicus)
REACT:R-CFA-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Canis familiaris)
REACT:R-DRE-373073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR1, 2 and 8 bind CCL16 ligand (Danio rerio)
REACT:R-RNO-1461995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-defensin alpha 5 is stored in Paneth cell granules (Rattus norvegicus)
REACT:R-XTR-1971483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Xenopus tropicalis)
REACT:R-DRE-9689680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNG inhibitors (Danio rerio)
RHEA:19193	skos:altLabel	"(13,14)-all-trans-retinol saturase"
RHEA:19193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-retinol 13,14-reductase"
RHEA:19193	skos:altLabel	"retinol saturase"
RHEA:19193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol
RHEA:19193	skos:prefLabel	"all-trans-retinol 13,14-reductase"
RHEA:19193	skos:altLabel	"RetSat"
REACT:R-SCE-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Saccharomyces cerevisiae)
REACT:R-HSA-9710353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds cardiolipin (Homo sapiens)
REACT:R-SPO-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Schizosaccharomyces pombe)
REACT:R-MMU-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Mus musculus)
REACT:R-HSA-9736970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter (Homo sapiens)
REACT:R-BTA-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Bos taurus)
REACT:R-MMU-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Mus musculus)
RHEA:24601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + sulfite => H2O2 + sulfate
REACT:R-MMU-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Mus musculus)
REACT:R-HSA-265422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaEbeta7 with Cadherin-1 (Homo sapiens)
RHEA:44492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-2173778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSR1 (SCARA1, SR-A) binds ligands (Homo sapiens)
RHEA:70438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 <=> a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate
REACT:R-SSC-5649799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)
REACT:R-CEL-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)
REACT:R-CFA-5654422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS2 (Canis familiaris)
GO:0047889	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	assimilatory nitrate reductase activity
GO:0047889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferredoxin-nitrate reductase activity
GO:0047889	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	assimilatory ferredoxin-nitrate reductase activity
GO:0047889	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite:ferredoxin oxidoreductase activity
GO:0047889	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrate (ferredoxin) reductase activity
REACT:R-SSC-6809264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Sus scrofa)
REACT:R-CEL-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Caenorhabditis elegans)
GO:1901680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur-containing amino acid secondary active transmembrane transporter activity
REACT:R-XTR-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Xenopus tropicalis)
RHEA:60436	skos:prefLabel	"isoamyl acetate esterase"
RHEA:60436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutyl acetate + H2O = 3-methylbutanol + acetate + H(+)
RHEA:60436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoamyl acetate esterase"
REACT:R-BTA-5690845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNIPs bind TNFAIP3 (A20) (Bos taurus)
REACT:R-DME-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Drosophila melanogaster)
RHEA:66218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-DeltaC7-CoA + H2O2 => asc-C7-CoA + O2
REACT:R-CFA-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Canis familiaris)
RHEA:33452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] => AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]
RHEA:46342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate => ATP + N-hexadecanoylsphing-4-enine
RHEA:40701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol
RHEA:34069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate
REACT:R-HSA-8868134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAST binds Ca2+ bound calpain (Homo sapiens)
RHEA:45791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol <=> 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA
RHEA:57585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:30726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 2 ADP + H(+) + NH4(+) + 2 phosphate <=> AH2 + 2 ATP + H2O + hydroxylamine
GO:0050310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfite-cytochrome c oxidoreductase activity
GO:0050310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphite dehydrogenase activity
GO:0050310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfite:ferricytochrome-c oxidoreductase activity
GO:0050310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfite cytochrome c reductase activity
GO:0050310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite dehydrogenase activity
REACT:R-CFA-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Canis familiaris)
REACT:R-DDI-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Dictyostelium discoideum)
RHEA:19329	skos:prefLabel	"nuatigenin 3beta-glucosyltransferase"
RHEA:19329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuatigenin + UDP-alpha-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP
RHEA:19329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nuatigenin 3beta-glucosyltransferase"
RHEA:70179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-maltotetraose = alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose
RHEA:71553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine => 5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine
REACT:R-RNO-5693148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDK phosphorylates BCKDH (Rattus norvegicus)
REACT:R-DDI-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Dictyostelium discoideum)
REACT:R-DDI-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Dictyostelium discoideum)
REACT:R-BTA-8875902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC45A3 transports Glc from extracellular region to cytosol (Bos taurus)
REACT:R-HSA-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)
REACT:R-MMU-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Mus musculus)
REACT:R-DME-983150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal cleavage of substrate (Drosophila melanogaster)
RHEA:51123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 <=> (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O
RHEA:52629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-fatty-acyl-L-alpha-amino acid + H2O => a fatty acid + an L-alpha-amino acid
RHEA:25515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + L-glutamate <=> chorismate + L-glutamine
REACT:R-RNO-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Rattus norvegicus)
RHEA:30922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + rhodopin <=> (3E)-3,4-didehydrorhodopin + AH2
REACT:R-SSC-141367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylation of tBID by NMT1 (Sus scrofa)
REACT:R-HSA-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Homo sapiens)
RHEA:47925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate
REACT:R-DDI-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Dictyostelium discoideum)
GO:0050324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurocyamine kinase activity
GO:0050324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:taurocyamine phosphotransferase activity
GO:0050324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:taurocyamine N-phosphotransferase activity
GO:0050324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurocyamine phosphotransferase activity
REACT:R-DME-174157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)
REACT:R-CFA-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Canis familiaris)
REACT:R-HSA-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Homo sapiens)
RHEA:61709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-seryl-5'-AMP => AMP + L-seryl-[peptidyl-carrier protein]
RHEA:70360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-3-oxosphinganine
REACT:R-DRE-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Danio rerio)
RHEA:31568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisphenol A + H(+) + NADH + O2 => 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)
REACT:R-CFA-9756177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse ATVL to ATV (Canis familiaris)
REACT:R-RNO-8981622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin:oxygen dissociates (Rattus norvegicus)
REACT:R-MMU-2029270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLCgamma to membrane (Mus musculus)
REACT:R-CEL-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Caenorhabditis elegans)
REACT:R-XTR-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
GO:0080059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol 3-O-arabinosyltransferase activity
REACT:R-BTA-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Bos taurus)
REACT:R-CFA-8955285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Canis familiaris)
REACT:R-HSA-9665121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 KD mutants bind TKIs (Homo sapiens)
REACT:R-MMU-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Mus musculus)
REACT:R-CEL-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Caenorhabditis elegans)
REACT:R-BTA-5623525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo-carrying vesicles bud from the TGN (Bos taurus)
RHEA:22947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5beta-pregnane-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH
RHEA:12826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine => [thioredoxin]-dithiol + H(+) + phosphate + sarcosine
REACT:R-BTA-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Bos taurus)
REACT:R-BTA-5696960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP49 deubiquitinates H2B (Bos taurus)
RHEA:72212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isoborneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH
RHEA:24416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H(+)
RHEA:24416	skos:prefLabel	"2,4'-dihydroxyacetophenone dioxygenase"
RHEA:24416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4'-dihydroxyacetophenone dioxygenase"
REACT:R-MMU-140840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Mus musculus)
EC:2.4.99.7	skos:altLabel	"NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase"
EC:2.4.99.7	skos:prefLabel	"alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase"
EC:2.4.99.7	skos:altLabel	"alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase"
EC:2.4.99.7	skos:altLabel	"sialyltransferase 7D"
EC:2.4.99.7	skos:altLabel	"ST6GALNAC"
EC:2.4.99.7	skos:altLabel	"sialyltransferase 3C"
EC:2.4.99.7	skos:altLabel	"cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase"
EC:2.4.99.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase"
EC:2.4.99.7	skos:altLabel	"sialyltransferase"
RHEA:21802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + H2O + L-dehydroascorbate => all-trans-antheraxanthin + L-ascorbate
GO:0004458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lactate-cytochrome c reductase activity
GO:0004458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-(-)-lactic cytochrome c reductase activity
GO:0004458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lactate ferricytochrome c oxidoreductase activity
GO:0004458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lactate (cytochrome) dehydrogenase activity
GO:0004458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome-dependent D-(-)-lactate dehydrogenase activity
GO:0004458	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lactic acid dehydrogenase activity
GO:0004458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lactate dehydrogenase (cytochrome) activity
GO:0004458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate:ferricytochrome-c 2-oxidoreductase activity
EC:2.7.1.183	skos:prefLabel	"glycoprotein-mannosyl O(6)-kinase"
EC:2.7.1.183	skos:altLabel	"protein O-mannose kinase"
EC:2.7.1.183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycoprotein-mannosyl O(6)-kinase"
REACT:R-BTA-4546386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO1 (Bos taurus)
REACT:R-GGA-2465917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerisation of 11c-retinyl to at-retinyl (Gallus gallus)
REACT:R-SSC-173542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 ubiquitinates SMAD2 (Sus scrofa)
RHEA:64749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate
REACT:R-RNO-877269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS-1 and SOCS-3 binds to p-JAK2 (Rattus norvegicus)
RHEA:59003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + propanal <=> H(+) + H2O2 + propanoate
REACT:R-HSA-9725315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK-stimulated MYCN gene expression (Homo sapiens)
RHEA:24233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH
RHEA:46386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-2213243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of COPII vesicle with Golgi complex (Sus scrofa)
REACT:R-MMU-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Mus musculus)
REACT:R-CFA-390252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)
REACT:R-SCE-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Saccharomyces cerevisiae)
REACT:R-GGA-629588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Gallus gallus)
RHEA:13684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Sus scrofa)
RHEA:48758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose + H(+) + NADH => erythritol + NAD(+)
REACT:R-CEL-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)
REACT:R-PFA-200396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Creatine transport across the plasma membrane (Plasmodium falciparum)
RHEA:35447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"norsolorinic acid ketoreductase"
RHEA:35447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S)-averantin + NADP(+) = H(+) + NADPH + norsolorinic acid
RHEA:35447	skos:prefLabel	"norsolorinic acid ketoreductase"
REACT:R-BTA-141156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL-mediated dimerization of procaspase-8 (Bos taurus)
RHEA:46885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
RHEA:27981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + H2O <=> alpha-D-mannose 1-phosphate + GMP + 2 H(+)
REACT:R-MMU-201637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plectin-1 (Mus musculus)
RHEA:63153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-fatty acyl-taurine + H2O => a fatty acid + taurine
REACT:R-HSA-1592244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates PPARGC1A (Homo sapiens)
REACT:R-GGA-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Gallus gallus)
RHEA:35929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-deamino-3''-hydroxykanamycin C + H(+) + UDP => paromamine + UDP-alpha-D-glucose
REACT:R-RNO-374909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabolism of Noradrenaline (Rattus norvegicus)
REACT:R-RNO-4420107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHC-transforming protein 2 (Rattus norvegicus)
RHEA:65412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP(in) + NAD(+)(out) = dAMP(out) + NAD(+)(in)
REACT:R-MMU-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Mus musculus)
RHEA:38767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:38327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol
RHEA:11567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-beta-D-glucopyranosyl-D-gluconate + phosphate <=> alpha-D-glucose 1-phosphate + D-gluconate
REACT:R-DRE-8941613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)
GO:0004734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidodiazepine synthase activity
GO:0004734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrimidodiazepine synthase"
GO:0004734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
GO:0004734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione
GO:0004734	skos:prefLabel	"pyrimidodiazepine synthase"
GO:0004734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDA synthase activity
REACT:R-DRE-1855172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Danio rerio)
REACT:R-SSC-2213246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of CLIP from MHC II (Sus scrofa)
REACT:R-XTR-5661114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Xenopus tropicalis)
RHEA:54111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + guaia-4,6-diene
REACT:R-SSC-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Sus scrofa)
REACT:R-DRE-8987063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Danio rerio)
RHEA:51565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:65677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine
REACT:R-HSA-9011077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHX2 binds to ROBO2 gene locus (Homo sapiens)
REACT:R-RNO-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Rattus norvegicus)
REACT:R-XTR-5678261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-XTR-203070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of profilin with monomeric actin (Xenopus tropicalis)
REACT:R-DME-400143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fatty acid ligands activate PPARA (Drosophila melanogaster)
RHEA:46410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:58230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide => L-asparaginyl-[protein] + NAD(+)
REACT:R-CFA-1433542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV1 (Canis familiaris)
GO:0072571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mono-ADP-D-ribose binding
GO:0072571	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	mono-ADP-ribose binding
GO:0072571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mADPr binding
REACT:R-RNO-158251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Rattus norvegicus)
RHEA:30353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxypyrrole-2-carboxylate + H2O + NAD(+) => H(+) + NADH + O2 + pyrrole-2-carboxylate
RHEA:38037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z)-2-oxohept-4-enedioate => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate
REACT:R-HSA-173542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 ubiquitinates SMAD2 (Homo sapiens)
REACT:R-SSC-2172433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIX degradation (Sus scrofa)
REACT:R-HSA-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Homo sapiens)
RHEA:33458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxyzymosterol + NADP(+) <=> CO2 + NADPH + zymosterone
GO:0102194	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructosamine-3-kinase activity
GO:0102194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-fructosamine 3-kinase activity
REACT:R-BTA-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Bos taurus)
GO:0102157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-sulfopropanediol 2-dehydrogenase activity
GO:0045030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled UTP receptor activity
GO:0045030	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	UTP-activated nucleotide receptor activity
GO:0045030	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	purinoceptor type U
GO:0045030	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uridine nucleotide receptor activity
REACT:R-DRE-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Danio rerio)
EC:4.5.1.-	skos:prefLabel	"Carbon-halide lyases"
EC:4.5.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carbon-halide lyases"
REACT:R-HSA-9618378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 binds the Nup107-Nup160 complex (Homo sapiens)
REACT:R-SSC-6791235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds AURKA (Sus scrofa)
REACT:R-MMU-9645406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Mus musculus)
REACT:R-HSA-432188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex (Homo sapiens)
RHEA:37870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:50711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione <=> (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
RHEA:15671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+) => a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP
REACT:R-MMU-378978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Mus musculus)
REACT:R-DDI-6814678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Dictyostelium discoideum)
REACT:R-HSA-997311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of TYK2 by PTP1B (Homo sapiens)
REACT:R-CEL-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Caenorhabditis elegans)
REACT:R-XTR-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Xenopus tropicalis)
GO:0102809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity
REACT:R-DRE-6809010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating (Danio rerio)
REACT:R-XTR-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Xenopus tropicalis)
REACT:R-DRE-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Danio rerio)
REACT:R-DDI-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Dictyostelium discoideum)
RHEA:41216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)
REACT:R-HSA-6804652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UACA binds apoptosome (Homo sapiens)
REACT:R-DDI-9635743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 binds p-T,Y-MAPK (Dictyostelium discoideum)
REACT:R-CFA-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Canis familiaris)
REACT:R-HSA-9609737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN2D (GRIN2D) (Homo sapiens)
RHEA:13421	skos:altLabel	"N-acetylneuraminate 9-phosphate synthetase"
RHEA:13421	skos:prefLabel	"N-acylneuraminate-9-phosphate synthase"
RHEA:13421	skos:altLabel	"N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase"
RHEA:13421	skos:altLabel	"N-acetylneuraminate 9-phosphate lyase"
RHEA:13421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate = an N-acylneuraminate 9-phosphate + phosphate
RHEA:13421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acylneuraminate-9-phosphate synthase"
RHEA:13421	skos:altLabel	"sialic acid 9-phosphate synthetase"
RHEA:13421	skos:altLabel	"N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating)"
GO:0004914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-5 receptor activity
GO:0004914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-5 receptor activity
GO:0004914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-5R
REACT:R-RNO-110232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by MBD4 glycosylase (Rattus norvegicus)
RHEA:61370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone sulfate(in) + ATP + H2O
RHEA:62745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mevastatin => (S)-2-methylbutanoate + compactin diol lactone + H(+)
REACT:R-BTA-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
RHEA:14825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-trans-carveol dehydrogenase"
RHEA:14825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH
RHEA:14825	skos:altLabel	"carveol dehydrogenase"
RHEA:14825	skos:prefLabel	"(+)-trans-carveol dehydrogenase"
RHEA:34925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(out) => nitrate(in)
REACT:R-CFA-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Canis familiaris)
REACT:R-DRE-1638845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERK phosphorylates CERA to form C1P (Danio rerio)
REACT:R-RNO-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Rattus norvegicus)
REACT:R-XTR-203712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS associates with Caveolin-1 (Xenopus tropicalis)
REACT:R-MMU-5649664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyG from damaged DNA (Mus musculus)
REACT:R-GGA-6806610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filament formation (Gallus gallus)
RHEA:36472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate(out) + H(+)(out) => 3,4,5-trihydroxybenzoate(in) + H(+)(in)
REACT:R-CFA-5632732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Canis familiaris)
RHEA:59688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaose + O2 = D-maltoheptaono-1,5-lactone + H2O2
REACT:R-DRE-8878050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 and EP300 (Danio rerio)
REACT:R-XTR-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Xenopus tropicalis)
RHEA:55825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1),7(1)-dihydroxybacteriochlorophyllide d => a bacteriochlorophyllide f + H2O
REACT:R-HSA-5211239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)
REACT:R-DRE-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Danio rerio)
REACT:R-RNO-6791227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Rattus norvegicus)
REACT:R-DRE-141348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAO:FAD oxidises NASPM to PTCN (Danio rerio)
REACT:R-DRE-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Danio rerio)
REACT:R-XTR-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Xenopus tropicalis)
REACT:R-DRE-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Danio rerio)
REACT:R-CFA-1475017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Canis familiaris)
RHEA:32672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UDP-N-acetyl-alpha-D-glucosamine => ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA-carnitine O-acetyltransferase activity
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine O-acetyltransferase activity
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CATC
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylcarnitine transferase activity
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carnitine O-acetyltransferase I activity
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine acetylase activity
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine acetyl coenzyme A transferase activity
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine acetyltransferase activity
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:carnitine O-acetyltransferase activity
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carnitine O-acetyltransferase II activity
GO:0004092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine-acetyl-CoA transferase activity
RHEA:50422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein]
RHEA:14328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxycoumarin + UDP-alpha-D-glucose <=> daphnin + H(+) + UDP
GO:0045505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynein intermediate chain binding
RHEA:67958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + chloride + H(+) => (S)-2-chloropropanoate + H2O
RHEA:41289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + tetradecanoate => H2O + N-tetradecanoylsphing-4-enine
REACT:R-BTA-9033961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Bos taurus)
RHEA:56712	skos:prefLabel	"phosphatidylglycerol--prolipoprotein diacylglyceryl transferase"
RHEA:56712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylglycerol--prolipoprotein diacylglyceryl transferase"
RHEA:56712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate
RHEA:40697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol
REACT:R-BTA-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Bos taurus)
REACT:R-GGA-443439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-Src binds Raf1 (Gallus gallus)
REACT:R-SCE-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Saccharomyces cerevisiae)
RHEA:62151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + dTMP <=> dGDP + dTDP
REACT:R-GGA-8854303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D11 binds RAB6 (Gallus gallus)
REACT:R-PFA-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)
REACT:R-RNO-5690023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL binds 4Fe-4S (Rattus norvegicus)
REACT:R-RNO-1482696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)
RHEA:31056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate + H2O => estrone + H(+) + sulfate
GO:0016768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity
GO:0016768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermine synthase activity
GO:0016768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spermine synthetase activity
GO:0016768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spermidine aminopropyltransferase activity
REACT:R-MMU-8875661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA3 associates with activated MET receptor (Mus musculus)
REACT:R-MMU-173705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b binds C6 (Mus musculus)
REACT:R-MMU-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Mus musculus)
RHEA:12731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,3'S)-zeaxanthin => lutein
RHEA:56163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate <=> an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP
REACT:R-SSC-73758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Sus scrofa)
REACT:R-CFA-5654620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
REACT:R-XTR-193719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Xenopus tropicalis)
REACT:R-MMU-203553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS binds NOSIP (Mus musculus)
RHEA:62719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stemphyloxin I <=> stemphyloxin II
RHEA:50790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-pent-3-en-2-one + H(+) + NADPH => NADP(+) + pentan-2-one
RHEA:66428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose(out) + H(+)(out) = D-arabinose(in) + H(+)(in)
REACT:R-SSC-2022919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Sus scrofa)
REACT:R-SSC-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Sus scrofa)
REACT:R-CEL-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
RHEA:58860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:39158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O
REACT:R-HSA-9625520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4 (Homo sapiens)
RHEA:52451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:72584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) => 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH
REACT:R-PFA-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Plasmodium falciparum)
REACT:R-XTR-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Xenopus tropicalis)
RHEA:43988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)
REACT:R-RNO-4719424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO1. (Rattus norvegicus)
REACT:R-GGA-5672329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CLIP1 and microtubules (Gallus gallus)
RHEA:65184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + preaustinoid A1 = berkeleyone B + CO2 + H2O + succinate
REACT:R-MMU-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Mus musculus)
REACT:R-GGA-5676596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds BAFFR:BAFF (Gallus gallus)
RHEA:39216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexacosenoyl-CoA + H(+) + NADPH => hexacosanoyl-CoA + NADP(+)
GO:0102569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FR-33289 synthase activity
REACT:R-HSA-211966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)
RHEA:53252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-191062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of Klotho-bound FGFR1c (Mus musculus)
RHEA:38949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:59206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+) => docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]
REACT:R-DME-429714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Drosophila melanogaster)
RHEA:11183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-asparagine + tRNA(Asn) <=> AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)
REACT:R-BTA-5654402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
RHEA:42910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1939) in 23S rRNA
GO:0061849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomeric G-quadruplex DNA binding
RHEA:19838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol 6-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH
RHEA:24195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)
REACT:R-HSA-8869543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFPA2A homodimer and NPM1 bind the NOP2 gene promoter (Homo sapiens)
GO:0050471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O3-acetyl-L-serine acetate-lyase (adding uracil)
GO:0050471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity
GO:0050471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity
GO:0050471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isowillardiine synthase activity
GO:0050471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity
GO:0050471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracilylalanine synthase activity
GO:0050471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Willardiine synthase activity
REACT:R-GGA-2132096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C4b:factor B complex (Gallus gallus)
REACT:R-HSA-3222533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2-activated AP1 complex binds KDM6B promoter (Homo sapiens)
RHEA:46522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysophosphatidase activity
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidase B
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-lysophosphatidylcholine acylhydrolase activity
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospholipase B activity
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lecitholipase activity
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysophosphatidylcholine hydrolase activity
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lecithinase B activity
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophospholipase activity
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysophopholipase L2
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysolecithinase activity
GO:0004622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysophospholipase A1
REACT:R-BTA-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Bos taurus)
REACT:R-HSA-9018325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG binds CXXC5 gene (Homo sapiens)
RHEA:42120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH
RHEA:12067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxopentanoate + H2O + NAD(+) <=> glutarate + 2 H(+) + NADH
RHEA:72289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dimethylsuccinate(in) + 3 Na(+)(in) => 2,2-dimethylsuccinate(out) + 3 Na(+)(out)
REACT:R-XTR-4084982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Xenopus tropicalis)
RHEA:61716	skos:prefLabel	"ABC-type D-galactofuranose transporter"
RHEA:61716	skos:altLabel	"D-galactofuranose ABC transporter"
RHEA:61716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-galactofuranose(out) + H2O = ADP + D-galactofuranose(in) + H(+) + phosphate
RHEA:61716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type D-galactofuranose transporter"
RHEA:61716	skos:altLabel	"D-galactofuranose transporting ATPase"
REACT:R-HSA-9604629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXW7 promotes ubiquitination of p-NICD4 (Homo sapiens)
REACT:R-DDI-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Dictyostelium discoideum)
RHEA:46086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + phosphate => H2O + sn-glycerol 1-phosphate
REACT:R-MMU-72185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA polyadenylation (Mus musculus)
RHEA:56235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate
RHEA:35863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-HSA-4719447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO1 (Homo sapiens)
RHEA:31229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-HSA-183002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Homo sapiens)
REACT:R-HSA-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Homo sapiens)
GO:0102143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxynorspermidine dehydrogenase I activity
RHEA:31522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + torulene <=> 3-methyl-2-butenal + 4'-apo-beta-carotenal
RHEA:37438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-2484965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII binds Integrin alpha1beta1 (Homo sapiens)
REACT:R-DME-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Drosophila melanogaster)
GO:0071713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	para-aminobenzoyl-glutamate hydrolase activity
GO:0140692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0140692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very long-chain fatty acid omega-hydroxylase activity
EC:1.1.1.423	skos:altLabel	"ephedrine dehydrogenase"
EC:1.1.1.423	skos:prefLabel	"(1R,2S)-ephedrine 1-dehydrogenase"
EC:1.1.1.423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(1R,2S)-ephedrine 1-dehydrogenase"
RHEA:71208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide(out) + 2 Na(+)(out) => iodide(in) + 2 Na(+)(in)
REACT:R-MMU-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Mus musculus)
RHEA:44045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
RHEA:34045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5''-phosphoribostamycin + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + neamine
REACT:R-CFA-420274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIP receptor binds gastric inhibitory peptide (Canis familiaris)
REACT:R-PFA-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Plasmodium falciparum)
REACT:R-CFA-976801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I complex formation (Canis familiaris)
REACT:R-SSC-448660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL31:IL31RA:JAK1 binds OSMR:JAK1 (Sus scrofa)
REACT:R-SSC-9014420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the phagocytic vesicle membrane (Sus scrofa)
REACT:R-CEL-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Caenorhabditis elegans)
RHEA:26518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O
GO:0120160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IFT A complex binding
GO:0120160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intraciliary transport complex A binding
GO:0120160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intraflagellar transport particle A binding
GO:0120160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intraflagellar transport complex A binding
GO:0120160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intraciliary transport particle A binding
RHEA:20775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) <=> 5-amino-6-(D-ribitylamino)uracil + riboflavin
RHEA:63908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + pravastatin(in) = ADP + H(+) + phosphate + pravastatin(out)
REACT:R-BTA-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Bos taurus)
REACT:R-CFA-6798044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTG2 binds CCR4-NOT complex (Canis familiaris)
REACT:R-DRE-8856525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANGPTL8 binds ANGPTL3 (Danio rerio)
REACT:R-DRE-4341048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RXRA with SUMO1 (Danio rerio)
REACT:R-DRE-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Danio rerio)
RHEA:51497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + ATP => a sphingoid 1-phosphate + ADP + H(+)
RHEA:29509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate
GO:0102601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102601	skos:prefLabel	"beta-amyrin 16beta-monooxygenase"
GO:0102601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-amyrin 16beta-monooxygenase"
GO:0102601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity
GO:0102601	skos:altLabel	"CYP716A141"
GO:0102601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9702593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib (Homo sapiens)
RHEA:33109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + gamma-muurolene => (2E,6E)-farnesyl diphosphate
REACT:R-MMU-74707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IRS to insulin receptor (Mus musculus)
REACT:R-DME-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Drosophila melanogaster)
RHEA:29285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(out) + Na(+)(out) => L-alanine(in) + Na(+)(in)
RHEA:37315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-glutamine + H2O = glycine + L-glutamine
REACT:R-XTR-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Xenopus tropicalis)
REACT:R-DME-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Drosophila melanogaster)
GO:0015606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine transmembrane transporter activity
GO:0015606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine(in) = spermidine(out)
REACT:R-BTA-2129385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFAP2, MFAP5 bind microfibrils (Bos taurus)
GO:0019956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chemokine binding
GO:0106283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH
GO:0106283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
REACT:R-DRE-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Danio rerio)
RHEA:40064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA
RHEA:38082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-CFA-198513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Canis familiaris)
REACT:R-CEL-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Caenorhabditis elegans)
REACT:R-DME-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Drosophila melanogaster)
REACT:R-SSC-9762343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDL:ALB dissociates (Sus scrofa)
REACT:R-MMU-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Mus musculus)
RHEA:24703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-alpha-D-glucuronate => CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose
REACT:R-DRE-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Danio rerio)
RHEA:67263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hept-2-enal + H2O + NAD(+) <=> (E)-hept-2-enoate + 2 H(+) + NADH
RHEA:68000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1-dichloroethene + AH2 = A + chloride + chloroethene + H(+)
REACT:R-CFA-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Canis familiaris)
REACT:R-DRE-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Danio rerio)
REACT:R-SSC-4641134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds AXIN (Sus scrofa)
GO:0047500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-borneol:NAD+ oxidoreductase activity
GO:0047500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bicyclic monoterpenol dehydrogenase activity
GO:0047500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-borneol dehydrogenase activity
RHEA:70319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate
GO:0008558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine ABC transporter
GO:0008558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent guanine transmembrane transporter activity
GO:0008558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled guanine transmembrane transporter activity
GO:0008558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type guanine transporter activity
GO:0008558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanine-transporting ATPase activity
REACT:R-RNO-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Rattus norvegicus)
REACT:R-GGA-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Gallus gallus)
REACT:R-DRE-8848751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds AKT1 (Danio rerio)
REACT:R-HSA-2466802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCA4 does not transport NRPE from disc membranes (Homo sapiens)
REACT:R-MMU-4088134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates FOXM1 (Mus musculus)
REACT:R-GGA-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Gallus gallus)
REACT:R-CEL-5218952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Caenorhabditis elegans)
REACT:R-SSC-9012657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Sus scrofa)
REACT:R-GGA-9023617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrylcholinesterase hydrolyzes acyl Ghrelin (Gallus gallus)
REACT:R-SCE-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Saccharomyces cerevisiae)
GO:0033878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hormone-sensitive lipase"
GO:0033878	skos:prefLabel	"hormone-sensitive lipase"
GO:0033878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hormone-sensitive lipase activity
GO:0033878	skos:altLabel	"HSL"
GO:0033878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HSL
GO:0033878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diacylglycerol acylhydrolase activity
GO:0047040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTR1
GO:0047040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrobiopterin reduction
GO:0047040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity
GO:0047040	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ptr1 activity
GO:0047040	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pteridine reductase 1 activity
GO:0047040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pteridine reductase activity
REACT:R-HSA-1989748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GRHL1 (Homo sapiens)
REACT:R-DME-2187330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)
RHEA:64949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + H2O => dCDP + H(+) + phosphate
REACT:R-GGA-5692437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANG binds F-actin (Gallus gallus)
RHEA:25796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + L-glutamate
RHEA:25796	skos:prefLabel	"aromatic-amino-acid transaminase"
RHEA:25796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aromatic-amino-acid transaminase"
GO:0047036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	codeinone reductase (NADPH) activity
GO:0047036	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	codeine:NADP+ oxidoreductase activity
RHEA:15288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate
RHEA:27642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate
GO:0047033	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostacyclin dehydrogenase activity
GO:0047033	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity
GO:0047033	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity
GO:0047033	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity
GO:0047033	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PG I2 dehydrogenase activity
GO:0047033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity
REACT:R-DME-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Drosophila melanogaster)
REACT:R-RNO-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Rattus norvegicus)
REACT:R-HSA-1604712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP7 by trypsin (Homo sapiens)
REACT:R-RNO-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Rattus norvegicus)
GO:0004197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type endopeptidase activity
GO:0004197	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	caspase activity
GO:0004197	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metacaspase activity
GO:0004197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiol endopeptidase activity
GO:0004197	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lysosomal cysteine-type endopeptidase
RHEA:68518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-acoradiene + diphosphate => (2Z,6Z)-farnesyl diphosphate
REACT:R-SSC-5696490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:CLCF1 binds CNTRF (Sus scrofa)
RHEA:14172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + glutarate <=> ADP + glutaryl-CoA + phosphate
RHEA:56844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nocamycin O-methyltransferase"
RHEA:56844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocamycin E + S-adenosyl-L-methionine = nocamycin I + S-adenosyl-L-homocysteine
RHEA:56844	skos:prefLabel	"nocamycin O-methyltransferase"
RHEA:42127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> androsterone + H(+) + NADH
RHEA:51615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + oxaloacetate <=> (R)-malate + 2-oxoglutarate
REACT:R-BTA-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Bos taurus)
RHEA:52527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-8939201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR dimerizes (Danio rerio)
REACT:R-XTR-350319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of vimentin at IDVD (259) (Xenopus tropicalis)
GO:0042009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-15 binding
GO:0042009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-15 binding
REACT:R-RNO-5654664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS binds GRB2:SOS1 (Rattus norvegicus)
REACT:R-RNO-8877813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND5A,B exchange GTP for GDP on RAB39 (Rattus norvegicus)
REACT:R-HSA-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Homo sapiens)
GO:0047491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alginase II activity
GO:0047491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly-alpha-L-guluronate lyase activity
GO:0047491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(alpha-L-1,4-guluronide) exo-lyase activity
GO:0047491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyguluronate-specific alginate lyase activity
GO:0047491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-guluronate lyase activity
GO:0047491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(alpha-L-guluronate) lyase activity
GO:0047491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guluronate lyase activity
GO:0047491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-guluronan lyase activity
REACT:R-BTA-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Bos taurus)
REACT:R-RNO-264865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin A (Rattus norvegicus)
REACT:R-DRE-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Danio rerio)
RHEA:30167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + dihydroxyacetone phosphate = D-sedoheptulose 1,7-bisphosphate
RHEA:68374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuccinamate + L-alanine => L-asparagine + pyruvate
RHEA:10571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-beta-D-glucuronide + UDP
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyllactosamine synthase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAL synthetase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-N-acetylglucosamine galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactose synthetase A protein
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-acetylglucosamine galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyllactosamine synthetase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-GalT
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-(1,4)-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosamine (beta-1,4)galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-beta-1,4-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosamine beta-(1,4)-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Gal-T
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactosamine synthetase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyllactosamine synthetase activity
GO:0003945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactosamine synthase activity
REACT:R-HSA-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)
REACT:R-RNO-173631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1s (Rattus norvegicus)
REACT:R-CFA-437139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT6 transports zinc into the golgi apparatus (Canis familiaris)
REACT:R-GGA-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Gallus gallus)
REACT:R-CFA-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Canis familiaris)
REACT:R-CEL-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Caenorhabditis elegans)
REACT:R-MMU-429767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Passive I- efflux mediated by SMCT1 (Mus musculus)
RHEA:12329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n) + phosphate => [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate
REACT:R-RNO-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Rattus norvegicus)
RHEA:69922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine(out) + 2 Na(+)(out) <=> inosine(in) + 2 Na(+)(in)
REACT:R-BTA-3640874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-RibC-AXIN is degraded by the proteasome (Bos taurus)
REACT:R-SSC-2396079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds Plasminogen activator inhibitor- 1 (Sus scrofa)
RHEA:40452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)
RHEA:32066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGDP + H2O <=> 8-oxo-dGMP + H(+) + phosphate
REACT:R-CEL-199935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates CREB (Caenorhabditis elegans)
REACT:R-BTA-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Bos taurus)
REACT:R-BTA-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Bos taurus)
REACT:R-HSA-193646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF binding to p75NTR inactivates RHOA (Homo sapiens)
REACT:R-CFA-202245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TBSMs in LAT (Canis familiaris)
EC:3.4.24.30	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coccolysin"
EC:3.4.24.30	skos:altLabel	"Streptococcus thermophilus intracellular proteinase"
EC:3.4.24.30	skos:prefLabel	"coccolysin"
RHEA:28055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CoA => formate + propanoyl-CoA
RHEA:18809	skos:altLabel	"alanine--oxomalonate aminotransferase"
RHEA:18809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + oxomalonate = aminomalonate + pyruvate
RHEA:18809	skos:prefLabel	"alanine--oxomalonate transaminase"
RHEA:18809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alanine--oxomalonate transaminase"
RHEA:18809	skos:altLabel	"L-alanine-ketomalonate transaminase"
GO:0046030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol trisphosphate phosphatase activity
GO:0046030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP(3) phosphatase activity
GO:0046030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3 phosphatase activity
RHEA:36717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-tetracosenoylsphinganine + CoA + H(+) => sphinganine + tetracosenoyl-CoA
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LDL-associated phospholipase A2
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	platelet-activating factor acetylhydrolase activity
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylacetyl-GPC:acetylhydrolase activity
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAF 2-acylhydrolase activity
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LDL-PLA2
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAF acetylhydrolase activity
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LDL-PLA(2) activity
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetyl-1-alkylglycerophosphocholine esterase activity
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LDL-associated phospholipase A(2) activity
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0003847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity
REACT:R-SSC-9708423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1:BACH1:Hemes are transported out of the nucleus (Sus scrofa)
GO:0047842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydro-L-gulonate decarboxylase activity
GO:0047842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydro-L-gulonate carboxy-lyase activity
GO:0047842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-keto-L-gulonate decarboxylase activity
GO:0047842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)
GO:0047842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	keto-L-gulonate decarboxylase activity
RHEA:59072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytidylyl-2-hydroxyethylphosphonate methyltransferase"
RHEA:59072	skos:prefLabel	"cytidylyl-2-hydroxyethylphosphonate methyltransferase"
RHEA:59072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
REACT:R-RNO-5626223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Rattus norvegicus)
REACT:R-CFA-4655355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Canis familiaris)
RHEA:63130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + ethanolamine => H2O + N-docosanoyl-ethanolamine
RHEA:44766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine
REACT:R-DDI-9027043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)
REACT:R-GGA-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Gallus gallus)
REACT:R-XTR-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Xenopus tropicalis)
RHEA:11015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophanamide <=> L-tryptophan + NH4(+)
REACT:R-HSA-168880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vRNP Export through the nuclear pore (Homo sapiens)
REACT:R-GGA-434362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment Of Cytoplasmic Proteins To Vesicles (Gallus gallus)
REACT:R-GGA-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Gallus gallus)
RHEA:33649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + AMP + diphosphate => (9Z)-hexadecenoate + ATP + CoA
RHEA:46632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)
RHEA:41354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-GGA-9758674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 oxidizes PREDN,PREDL (Gallus gallus)
RHEA:44003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 <=> 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:DAC acetyltransferase activity
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A:DAC acetyltransferase activity
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAC acetyltransferase activity
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:DAC O-acetyltransferase activity
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAC-AT
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cefG
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPC acetylhydrolase activity
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetylcephalosporin C acetyltransferase activity
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity
GO:0033813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylcephalosporin-C acetyltransferase activity
REACT:R-HSA-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Homo sapiens)
REACT:R-DDI-5672948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK3 phosphorylates KSR1 (Dictyostelium discoideum)
REACT:R-MMU-201445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Mus musculus)
REACT:R-PFA-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Plasmodium falciparum)
RHEA:11466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + 2 L-homocysteine => 2 glutathione + L,L-homocystine
REACT:R-HSA-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Homo sapiens)
RHEA:14393	skos:prefLabel	"cypemycin N-terminal methyltransferase"
RHEA:14393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cypemycin N-terminal methyltransferase"
RHEA:14393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine
RHEA:70531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP
REACT:R-MMU-174132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Cyclin B:Cdc2 (Mus musculus)
RHEA:33048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]
RHEA:34962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) <=> (R)-carnitine(out)
RHEA:18259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 2 H2O + protoporphyrinogen IX => coproporphyrinogen III + 2 H(+) + O2
RHEA:62936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+)
RHEA:55774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonyl-L-amino acid + AMP + diphosphate + H(+) => a jasmonate + an L-alpha-amino acid + ATP
RHEA:56911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-O-acetylsalutaridinol <=> acetate + H(+) + thebaine
GO:0033978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphonopyruvate hydrolase activity
GO:0033978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPH
RHEA:50553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin C1 => prostaglandin B1
REACT:R-CEL-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Caenorhabditis elegans)
RHEA:67934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + desmosterol(out) + H(+) + phosphate => ATP + desmosterol(in) + H2O
GO:0018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene-3,4-epoxide hydrolase activity
RHEA:12716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 5'-phosphate + ATP <=> a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)
RHEA:64351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) <=> deacetylpyripyropene E
REACT:R-MMU-8851011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 polyubiquitinates PTEN (Mus musculus)
REACT:R-HSA-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Homo sapiens)
EC:1.11.1.6	skos:prefLabel	"catalase"
EC:1.11.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"catalase"
REACT:R-DRE-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Danio rerio)
REACT:R-HSA-6800794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 associates with CRADD (Homo sapiens)
REACT:R-MMU-6786050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Mus musculus)
REACT:R-RNO-8937369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAD2 binds ESR1 (Rattus norvegicus)
REACT:R-HSA-9023549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 gene expression is inhibited by MECP2 (Homo sapiens)
REACT:R-CEL-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Caenorhabditis elegans)
GO:0047720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleacetaldoxime hydro-lyase activity
GO:0047720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(indol-3-yl)acetaldehyde-oxime hydro-lyase activity
GO:0047720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]
GO:0047720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoleacetaldoxime dehydratase activity
GO:0047720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-indoleacetaldoxime hydro-lyase activity
GO:0047720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-acetaldehyde-oxime hydro-lyase activity
GO:0047720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-acetaldoxime hydro-lyase activity
EC:2.4.1.18	skos:altLabel	"amylo-(1,4 to 1,6)transglucosidase"
EC:2.4.1.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,4-alpha-glucan branching enzyme"
EC:2.4.1.18	skos:prefLabel	"1,4-alpha-glucan branching enzyme"
EC:2.4.1.18	skos:altLabel	"amylo-(1,4->1,6)-transglycosylase"
EC:2.4.1.18	skos:altLabel	"glycogen branching enzyme"
EC:2.4.1.18	skos:altLabel	"branching enzyme"
RHEA:66922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate => 6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate
REACT:R-DDI-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Dictyostelium discoideum)
REACT:R-DRE-5662620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds cadmium (Danio rerio)
RHEA:17582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O => an L-alpha-amino acid + CO2 + NH4(+)
RHEA:23873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-propane-1,2-diol + NAD(+) => (R)-lactaldehyde + H(+) + NADH
REACT:R-RNO-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Rattus norvegicus)
RHEA:50078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:19505	skos:altLabel	"arabinosylindolylacetylinositol synthase"
RHEA:19505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indolylacetylinositol arabinosyltransferase"
RHEA:19505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP
RHEA:19505	skos:prefLabel	"indolylacetylinositol arabinosyltransferase"
REACT:R-GGA-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Gallus gallus)
RHEA:40715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
REACT:R-CEL-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Caenorhabditis elegans)
GO:0015193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Homo sapiens)
GO:0015193	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycine betaine/proline porter activity
GO:0015193	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proline/glycine/betaine:hydrogen/sodium symporter activity
GO:0015193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline transmembrane transporter activity
GO:0015193	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-proline transporter activity
GO:0015193	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-proline permease activity
RHEA:63025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenamide + H2O => (13Z)-docosenoate + NH4(+)
REACT:R-SPO-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Schizosaccharomyces pombe)
REACT:R-HSA-4827388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)
REACT:R-CEL-9701531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727 STAT3 is acetylated (Caenorhabditis elegans)
GO:0004797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thymidine kinase"
GO:0004797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxythymidine kinase activity
GO:0004797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine kinase (phosphorylating)
GO:0004797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxythymidine kinase (phosphorylating)
GO:0004797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:thymidine 5'-phosphotransferase activity
GO:0004797	skos:prefLabel	"thymidine kinase"
GO:0004797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine kinase activity
GO:0004797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thymidine = ADP + dTMP + H(+)
REACT:R-RNO-9011984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A is recruited to MYC and BCL2 genes (Rattus norvegicus)
RHEA:38417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O
RHEA:18604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2
RHEA:28953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-arabinose(out) => H(+)(in) + L-arabinose(in)
GO:0050107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:monoterpenol O-acetyltransferase activity
GO:0050107	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	menthol transacetylase activity
GO:0050107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoterpenol O-acetyltransferase activity
REACT:R-HSA-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Homo sapiens)
REACT:R-BTA-166721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Bos taurus)
RHEA:35758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-alpha-D-glucose <=> H(+) + NADH + UDP-3-oxo-alpha-D-glucose
REACT:R-CFA-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Canis familiaris)
RHEA:17303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]
REACT:R-MMU-9667619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B,2 bind atosiban (Mus musculus)
REACT:R-HSA-933531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)
REACT:R-CEL-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Caenorhabditis elegans)
REACT:R-DME-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Drosophila melanogaster)
RHEA:40917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O
RHEA:14498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + pyridoxine => AH2 + isopyridoxal
RHEA:55699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O <=> an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate
REACT:R-BTA-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Bos taurus)
REACT:R-XTR-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Xenopus tropicalis)
RHEA:12759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + zeatin => dihydrozeatin + NADP(+)
REACT:R-DRE-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Danio rerio)
RHEA:30252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinol + n H(+)(in) + O2 => 2 a ubiquinone + n H(+)(out) + 2 H2O
RHEA:43997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 => a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate
RHEA:52371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + cholesterol <=> adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)
RHEA:12819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biochanin A + 2 H(+) + NADPH => 2,3-dihydrobiochanin A + NADP(+)
RHEA:57853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase
RHEA:11479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 1-phosphate + H2O <=> glycerol + phosphate
GO:0015368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Homo sapiens)
GO:0015368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium:cation antiporter activity
REACT:R-DRE-8850529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGS proteins bind GNB5 and CCT/TRiC (Danio rerio)
REACT:R-SSC-1474213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP1,8,9,13 (Sus scrofa)
REACT:R-HSA-9031881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPAn-3 resolvins translocate from cytosol to extracellular region (Homo sapiens)
RHEA:58569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine + acetyl-CoA => CoA + O-acetyl-15alpha-stemmadenine
GO:0047362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulphate-dithiol sulphurtransferase activity
GO:0047362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate:dithioerythritol sulfurtransferase activity
GO:0047362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TSR
GO:0047362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate reductase activity
GO:0047362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate-dithiol sulfurtransferase activity
REACT:R-SCE-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Saccharomyces cerevisiae)
RHEA:39008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cholesterol ester(in) => a cholesterol ester(out)
REACT:R-HSA-164377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
REACT:R-RNO-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Rattus norvegicus)
GO:0052614	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyrimidine oxygenase activity
GO:0052614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil oxygenase activity
REACT:R-BTA-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Bos taurus)
GO:0000701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine-specific mismatch base pair DNA N-glycosylase activity
GO:0000701	skos:prefLabel	"adenine glycosylase"
GO:0000701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenine glycosylase"
GO:0000701	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A/G-specific adenine DNA glycosylase activity
GO:0000701	skos:altLabel	"A/G-specific adenine glycosylase"
REACT:R-HSA-8939039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPANT translocates from extracellular region to cytosol (Homo sapiens)
RHEA:67516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-RNO-5607750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Rattus norvegicus)
REACT:R-RNO-9027321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Rattus norvegicus)
REACT:R-MMU-377644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of CSK from SRC (Mus musculus)
RHEA:49006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2
RHEA:58787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 <=> a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate
REACT:R-CEL-9634834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACHEIs bind ACHE (Caenorhabditis elegans)
RHEA:51266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:32676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose
REACT:R-CFA-216043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II binds integrin alpha10beta1 (Canis familiaris)
REACT:R-DDI-8874705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Dictyostelium discoideum)
RHEA:35820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + NADP(+) => 7,8-dihydromethanopterin + H(+) + NADPH
RHEA:56219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP
RHEA:11063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-isoleucine + tRNA(Ile) <=> AMP + diphosphate + L-isoleucyl-tRNA(Ile)
REACT:R-RNO-6805126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates TP53 (Rattus norvegicus)
REACT:R-CFA-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Canis familiaris)
RHEA:40748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysine + O2 => (3S)-3-hydroxy-L-lysine + CO2 + succinate
RHEA:18590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutamine synthetase]-L-tyrosine + ATP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate
RHEA:67745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O => 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate
GO:0031716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitonin receptor binding
GO:0031716	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcitonin receptor ligand
GO:0008825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)
GO:0008825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CFA synthase activity
GO:0008825	skos:altLabel	"CFA synthase"
GO:0008825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine
GO:0008825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclopropane-fatty-acyl-phospholipid synthase"
GO:0008825	skos:altLabel	"cyclopropane fatty acid synthase"
GO:0008825	skos:altLabel	"unsaturated-phospholipid methyltransferase"
GO:0008825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclopropane fatty acid synthetase activity
GO:0008825	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	unsaturated-phospholipid methyltransferase activity
GO:0008825	skos:prefLabel	"cyclopropane-fatty-acyl-phospholipid synthase"
GO:0008825	skos:altLabel	"cyclopropane synthetase"
GO:0008825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopropane-fatty-acyl-phospholipid synthase activity
GO:0008825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclopropane synthase activity
GO:0008825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclopropane fatty acid synthase activity
GO:0008825	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclopropane synthetase activity
RHEA:37281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-alanyl-L-histidine(in) + phosphate => ATP + H2O + L-alanyl-L-histidine(out)
REACT:R-MMU-446130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 2 binds Interleukin 1 (Mus musculus)
REACT:R-DRE-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Danio rerio)
REACT:R-DRE-8944240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type III (Danio rerio)
REACT:R-MMU-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Mus musculus)
GO:0015277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kainate selective glutamate receptor activity
RHEA:20553	skos:altLabel	"methylmalonyl-CoA racemase"
RHEA:20553	skos:prefLabel	"methylmalonyl-CoA epimerase"
RHEA:20553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA
RHEA:20553	skos:altLabel	"methylmalonyl coenzyme A racemase"
RHEA:20553	skos:altLabel	"2-methyl-3-oxopropanoyl-CoA 2-epimerase"
RHEA:20553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylmalonyl-CoA epimerase"
RHEA:20553	skos:altLabel	"DL-methylmalonyl-CoA racemase"
REACT:R-RNO-428205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [Golgi] (Rattus norvegicus)
RHEA:72500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + prostaglandin E2(out) => 2-oxoglutarate(out) + prostaglandin E2(in)
REACT:R-CFA-83660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-anchored TNF-α binds TNFR1 (Canis familiaris)
REACT:R-MMU-1605717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Mus musculus)
RHEA:70244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-xylose => a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP
REACT:R-DRE-1250189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Danio rerio)
REACT:R-DDI-5423653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGST trimers transfer GS from GSH to AFXBO and AFNBO (Dictyostelium discoideum)
REACT:R-HSA-912450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR Kinase is recruited to unsynapsed regions (Homo sapiens)
RHEA:21065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + 2 glutathione => [protein]-dithiol + glutathione disulfide
RHEA:37245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA
REACT:R-MMU-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Mus musculus)
RHEA:25579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + protoporphyrinogen IX <=> 3 H2O2 + protoporphyrin IX
RHEA:34164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone + O2 => (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)
REACT:R-DRE-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Danio rerio)
RHEA:46863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP
REACT:R-CFA-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Canis familiaris)
RHEA:25700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-hexahomomethionine
REACT:R-SSC-168933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of phosphorylated IRF3/IRF7 (Sus scrofa)
REACT:R-HSA-6814678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)
RHEA:25939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-methylquinoline + A + H2O <=> 8-methylquinolin-2(1H)-one + AH2
REACT:R-BTA-5655142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 binds POLH (Bos taurus)
RHEA:33852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) => GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine
GO:0019108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-aldehyde:NAD+ oxidoreductase activity
GO:0019108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryl-aldehyde dehydrogenase (NAD) activity
GO:0019108	skos:prefLabel	"aryl-aldehyde dehydrogenase"
GO:0019108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + H2O + NAD(+) = an aromatic carboxylate + 2 H(+) + NADH
GO:0019108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aryl-aldehyde dehydrogenase"
RHEA:20039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucose 6-phosphate + H(+) + NADPH => D-sorbitol 6-phosphate + NADP(+)
RHEA:22135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-maltose(out) + H2O <=> ADP + D-maltose(in) + H(+) + phosphate
EC:1.14.13.216	skos:prefLabel	"asperlicin C monooxygenase"
EC:1.14.13.216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"asperlicin C monooxygenase"
REACT:R-BTA-382061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular processing of novel PDGFs (Bos taurus)
REACT:R-SPO-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Schizosaccharomyces pombe)
REACT:R-CEL-451377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IQGAP1 with nephrin (Caenorhabditis elegans)
RHEA:50169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine
REACT:R-HSA-140783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Homo sapiens)
REACT:R-CFA-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Canis familiaris)
REACT:R-CFA-9014424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the phagocytic vesicle membrane (Canis familiaris)
REACT:R-GGA-9756183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Gallus gallus)
REACT:R-HSA-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)
RHEA:17630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose(in) => alpha,alpha-trehalose(out)
REACT:R-RNO-9679028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 binds JAK3 inhibitors (Rattus norvegicus)
RHEA:47081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyestr-4-en-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-estran-3-one + NADP(+)
RHEA:38485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O
RHEA:39529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH
RHEA:55762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP] => a fatty acyl-[ACP] + a lyso-ornithine lipid
RHEA:31721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Xenopus tropicalis)
RHEA:55935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O <=> AMP + H(+) + L-threonyl-[protein]
REACT:R-HSA-388503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxytocin receptor bind oxytocin (Homo sapiens)
REACT:R-CFA-2294580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 hyperphosphorylates Condensin II complex (Canis familiaris)
RHEA:21385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine => (E)-cinnamate + NH4(+)
REACT:R-HSA-8874080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates PTK2 (Homo sapiens)
RHEA:46124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"24-hydroxycholesterol 7alpha-hydroxylase"
RHEA:46124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46124	skos:altLabel	"24-hydroxycholesterol 7alpha-monooxygenase"
RHEA:46124	skos:prefLabel	"24-hydroxycholesterol 7alpha-hydroxylase"
RHEA:70864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + L-threonine(in) + Na(+)(out) => L-glutamine(in) + L-threonine(out) + Na(+)(in)
GO:0034057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA strand-exchange activity
RHEA:19138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + AH2 + O2 => 6beta-hydroxyestradiol-17beta + A + H2O
RHEA:17153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O
RHEA:17153	skos:prefLabel	"CDP-glucose 4,6-dehydratase"
RHEA:17153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-glucose 4,6-dehydratase"
REACT:R-RNO-2168883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin:Hemoglobin binds CD163 (Rattus norvegicus)
GO:0015652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quaternary ammonium group:proton symporter activity
GO:0015652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quaternary ammonium group:hydrogen symporter activity
REACT:R-HSA-2769007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants (Homo sapiens)
RHEA:29381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + phosphate => dGMP + H2O
RHEA:71641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K(+)(out) + Na(+)(out) => K(+)(in) + Na(+)(in)
REACT:R-BTA-5696213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to methylarsonite (Bos taurus)
REACT:R-BTA-191763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP:Snurportin complex formation (Bos taurus)
REACT:R-CEL-373724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds NCK (Caenorhabditis elegans)
REACT:R-HSA-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Homo sapiens)
REACT:R-GGA-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Gallus gallus)
RHEA:15578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + uridine => D-ribose + uracil
REACT:R-MMU-5617179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates TNNI3 (Mus musculus)
REACT:R-SSC-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Sus scrofa)
REACT:R-SCE-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Saccharomyces cerevisiae)
REACT:R-SSC-549304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal clearance of organic cations (Sus scrofa)
REACT:R-XTR-425822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Xenopus tropicalis)
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	licheninase activity
GO:0042972	skos:altLabel	"1,3-1,4-beta-D-glucan 4-glucanohydrolase"
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-1,3-1,4 glucanase activity
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3;1,4-beta-glucan endohydrolase activity
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-1,4-beta-D-glucan 4-glucanohydrolase activity
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-glucanase activity
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mixed linkage beta-glucanase activity
GO:0042972	skos:prefLabel	"licheninase"
GO:0042972	skos:altLabel	"lichenase"
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3;1,4-beta-glucan 4-glucanohydrolase activity
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lichenase activity
GO:0042972	skos:altLabel	"beta-glucanase"
GO:0042972	skos:altLabel	"mixed linkage beta-glucanase"
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-1,4-beta-glucan 4-glucanohydrolase activity
GO:0042972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"licheninase"
GO:0042972	skos:altLabel	"endo-beta-1,3-1,4 glucanase"
RHEA:23170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxocoformycin + H(+) + NADPH => coformycin + NADP(+)
RHEA:22383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O <=> [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol
REACT:R-CEL-8876319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC50A1 transports Glc from cytosol to extracellular region (Caenorhabditis elegans)
REACT:R-CEL-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Caenorhabditis elegans)
REACT:R-BTA-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Bos taurus)
REACT:R-DRE-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Danio rerio)
REACT:R-RNO-9749583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Rattus norvegicus)
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905056	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
REACT:R-SSC-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Sus scrofa)
REACT:R-DME-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Drosophila melanogaster)
GO:0005126	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
GO:0005126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokine receptor binding
GO:0005126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hematopoietin/interferon-class (D200-domain) cytokine receptor binding
REACT:R-XTR-8852522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 dimer:MST1R dimer binds MST1R dimer (Xenopus tropicalis)
REACT:R-SCE-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Saccharomyces cerevisiae)
REACT:R-RNO-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Rattus norvegicus)
REACT:R-SSC-5423117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates MeK21-histone H4 (Sus scrofa)
REACT:R-HSA-1471314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNP1-3 bind CD4 (Homo sapiens)
REACT:R-CFA-5655170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 monoubiquitinates POLH (Canis familiaris)
RHEA:45445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate
REACT:R-XTR-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Xenopus tropicalis)
RHEA:38016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocotrienol => 6-geranylgeranyl-2-methylbenzene-1,4-diol
REACT:R-CFA-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Canis familiaris)
RHEA:23142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + H2O
RHEA:61653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] => 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate
RHEA:30371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone
RHEA:10740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + NAD(+) = a ketone + H(+) + NADH
RHEA:69951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
RHEA:62563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + A + H2O <=> (4R)-perillyl alcohol + AH2
REACT:R-GGA-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Gallus gallus)
REACT:R-MMU-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Mus musculus)
RHEA:46801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0050353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TMLD activity
GO:0050353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethyllysine alpha-ketoglutarate dioxygenase activity
GO:0050353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethyllysine dioxygenase activity
GO:0050353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TML dioxygenase activity
GO:0050353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethyllysine,2-oxoglutarate dioxygenase activity
GO:0050353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TML hydroxylase activity
GO:0050353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity
GO:0050353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
GO:0050353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TML-alpha-ketoglutarate dioxygenase activity
GO:0050353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
REACT:R-SSC-2066299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 binds phosphorylated WWTR1 (TAZ) (Sus scrofa)
RHEA:38183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine = a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Bos taurus)
REACT:R-CEL-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Caenorhabditis elegans)
REACT:R-RNO-71260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Rattus norvegicus)
RHEA:27865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-GMP + H2O <=> guanosine + phosphate
RHEA:24484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + sulcatol = H(+) + NADH + sulcatone
RHEA:24484	skos:prefLabel	"sulcatone reductase"
RHEA:24484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulcatone reductase"
REACT:R-BTA-3900194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates DDX5 with SUMO2 (Bos taurus)
REACT:R-XTR-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Xenopus tropicalis)
REACT:R-HSA-5689085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds polyUb-PARK2 (Homo sapiens)
REACT:R-BTA-212005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2F1 dehydrogenates 3-methylindole (Bos taurus)
RHEA:47575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) <=> CMP + ganglioside GT1b (d18:1(4E)) + H(+)
REACT:R-CEL-8875451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates CBL (Caenorhabditis elegans)
GO:0047544	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)
GO:0047544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybiphenyl 3-monooxygenase activity
RHEA:45883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA
RHEA:60996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-leucine + O2 = 4-methyl-2-oxopentanoate + H2O2 + NH4(+)
RHEA:25915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-5-ol <=> 5-hydroxyquinolin-2(1H)-one + AH2
RHEA:57177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + methylglyoxal => N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]
RHEA:71137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-histidine(in) + Na(+)(in) => H(+)(in) + L-histidine(out) + Na(+)(out)
REACT:R-BTA-936947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Bos taurus)
REACT:R-BTA-420123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like receptor 2 binds GLP2 (Bos taurus)
REACT:R-PFA-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)
RHEA:38494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)
REACT:R-XTR-5663050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHI and DHICA polymerise forming eumelanin (Xenopus tropicalis)
REACT:R-SSC-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Sus scrofa)
REACT:R-DRE-9007901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RL2 (Danio rerio)
REACT:R-DRE-9011748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R binds JAK1 (Danio rerio)
EC:1.2.1.24	skos:prefLabel	"succinate-semialdehyde dehydrogenase (NAD(+))"
EC:1.2.1.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinate-semialdehyde dehydrogenase (NAD(+))"
RHEA:12437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + putrescine => CoA + H(+) + N-caffeoylputrescine
REACT:R-HSA-9614369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of HCMV DNA Into the Nucleus (Homo sapiens)
EC:1.1.99.24	skos:prefLabel	"hydroxyacid-oxoacid transhydrogenase"
EC:1.1.99.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyacid-oxoacid transhydrogenase"
REACT:R-RNO-187895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)
GO:0004107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate synthase activity
GO:0004107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity
GO:0004107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)
GO:0004107	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-enolpyruvylshikimate-3-phosphate phospholyase activity
REACT:R-CEL-5662660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopachrome is transformed to DHICA by DCT (Caenorhabditis elegans)
REACT:R-XTR-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Xenopus tropicalis)
RHEA:22680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dCTP deaminase"
RHEA:22680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + H(+) + H2O = dUTP + NH4(+)
RHEA:22680	skos:prefLabel	"dCTP deaminase"
RHEA:22680	skos:altLabel	"deoxycytidine triphosphate deaminase"
REACT:R-HSA-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Homo sapiens)
RHEA:45583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactaro-1,5-lactone <=> D-galactaro-1,4-lactone
REACT:R-CFA-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Canis familiaris)
REACT:R-XTR-5685606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC2D binds KLRB1 (Xenopus tropicalis)
RHEA:29060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + H2 + ubiquinone-8 => 2 H(+)(out) + ubiquinol-8
REACT:R-RNO-399712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Rattus norvegicus)
REACT:R-HSA-8949703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) (Homo sapiens)
RHEA:53799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholoyl-CoA + ursodeoxycholate <=> deoxycholate + ursodeoxycholoyl-CoA
RHEA:44262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA
REACT:R-BTA-211991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclophosphamide is 4-hydroxylated by CYP2B6 (Bos taurus)
RHEA:39604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O
RHEA:28736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + spermidine(out) => H(+)(out) + spermidine(in)
RHEA:58225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-[protein] + NAD(+) => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide
RHEA:71108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(out) + S-methylmercury-L-cysteine(in) => L-leucine(in) + S-methylmercury-L-cysteine(out)
RHEA:37984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol => 2,3-dimethyl-6-phytylbenzene-1,4-diol
RHEA:45062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + ethanolamine => H2O + N-(9Z-octadecenoyl) ethanolamine
RHEA:62624	skos:prefLabel	"glutaredoxin-dependent peroxiredoxin"
RHEA:62624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutaredoxin-dependent peroxiredoxin"
RHEA:62624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutaredoxin]-dithiol + a hydroperoxide = [glutaredoxin]-disulfide + an alcohol + H2O
REACT:R-BTA-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Bos taurus)
REACT:R-CFA-168166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
RHEA:52570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => epitestosterone + UDP-alpha-D-glucuronate
REACT:R-XTR-8866941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MID1IP1 binds THRSP (Xenopus tropicalis)
RHEA:61507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin + UDP-alpha-D-glucose <=> pelargonidin 3-O-beta-D-glucoside + UDP
REACT:R-CFA-8949659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Canis familiaris)
REACT:R-RNO-9032073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-phosphorylated FRS2 binds GRB2 (Rattus norvegicus)
RHEA:23866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate
RHEA:62873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 => H2O + NADP(+) + semiviriditoxin
REACT:R-XTR-9020256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Xenopus tropicalis)
RHEA:58419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-en-1-ol + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH
REACT:R-BTA-873918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of JAK1 (Bos taurus)
REACT:R-DRE-2213205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type XII and XIV collagens associate with type I and type II fibrils. (Danio rerio)
RHEA:36301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + AMP + diphosphate => (E)-caffeate + ATP + CoA
GO:0045523	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-27 receptor ligand
GO:0045523	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-27
GO:0045523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-27 receptor binding
REACT:R-CEL-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Caenorhabditis elegans)
REACT:R-MMU-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
RHEA:44112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + nonan-1-ol = CoA + nonyl hexadecanoate
RHEA:40995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA = 4-hydroxybenzaldehyde + acetyl-CoA
RHEA:65627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine <=> CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine
EC:2.4.1.212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hyaluronan synthase"
EC:2.4.1.212	skos:altLabel	"HAS"
EC:2.4.1.212	skos:prefLabel	"hyaluronan synthase"
REACT:R-HSA-8874979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD3 binds GOLGB1 (Homo sapiens)
RHEA:35610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin + NADP(+) <=> diacetyl + H(+) + NADPH
REACT:R-HSA-2129375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin cross-linking by lysyl oxidase (Homo sapiens)
RHEA:34743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine 1-phosphate = 13-methyltetradecanal + phosphoethanolamine
REACT:R-HSA-994034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Interferon-alpha and beta (Homo sapiens)
RHEA:40704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:34465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-abienol + diphosphate => 8-hydroxycopalyl diphosphate
REACT:R-HSA-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Homo sapiens)
REACT:R-RNO-266012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTD4 is converted to LTE4 by DPEP1/2 (Rattus norvegicus)
REACT:R-DDI-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Dictyostelium discoideum)
REACT:R-BTA-2186767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SKI/SKIL (Bos taurus)
RHEA:26496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2
REACT:R-CFA-879221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSTPIP1 binds Pyrin (Canis familiaris)
RHEA:38600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + nicotinate => nicotinamide + nicotinate-adenine dinucleotide phosphate
REACT:R-DDI-5694421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6 dephosphorylates SEC24 (Dictyostelium discoideum)
REACT:R-RNO-8983378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Rattus norvegicus)
REACT:R-SSC-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Sus scrofa)
RHEA:33982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIBOA beta-D-glucoside + H2O <=> D-glucose + DIBOA
RHEA:55237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)
REACT:R-MMU-5618105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)
GO:0050636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vinorine synthase activity
GO:0050636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing)
REACT:R-CEL-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)
REACT:R-HSA-1302698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR associates with JAK2 (Homo sapiens)
REACT:R-DDI-8854044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Dictyostelium discoideum)
RHEA:40417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanoate + CoA + H(+) => H2O + pristanoyl-CoA
RHEA:59778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose + H2O2 => D-arabinitol + O2
REACT:R-HSA-3204311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOX1 oxidises PXL to PDXate (Homo sapiens)
REACT:R-XTR-5654409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS2 (Xenopus tropicalis)
REACT:R-DRE-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Danio rerio)
RHEA:64544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine = 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine
RHEA:14946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP
RHEA:53455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester
RHEA:44415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-10 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-10
REACT:R-CEL-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Caenorhabditis elegans)
RHEA:10352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetylarylalkylamine + H2O = acetate + an aralkylamine
REACT:R-HSA-9639698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS positively regulates misfolding of cilia proteins (Homo sapiens)
RHEA:21681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxyphytanate + O2 => 2-oxophytanate + H2O2
RHEA:46952	skos:prefLabel	"formate dehydrogenase (NAD(+), ferredoxin)"
RHEA:46952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:46952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate dehydrogenase (NAD(+), ferredoxin)"
RHEA:46952	skos:altLabel	"electron-bifurcating formate dehydrogenase"
GO:0019179	skos:altLabel	"thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase"
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity
GO:0019179	skos:altLabel	"thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase"
GO:0019179	skos:altLabel	"dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase"
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-amino-4,6-dideoxy-D-glucose transaminase"
GO:0019179	skos:prefLabel	"dTDP-4-amino-4,6-dideoxy-D-glucose transaminase"
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDP-4-keto-6-deoxy-D-glucose transaminase activity
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDP-4-oxo-6-deoxy-D-glucose transaminase activity
GO:0019179	skos:altLabel	"TDP-4-keto-6-deoxy-D-glucose transaminase"
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
GO:0019179	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity
REACT:R-DDI-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)
REACT:R-GGA-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Gallus gallus)
REACT:R-RNO-975594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLB1 hydrolyses RPALM to atROL (Rattus norvegicus)
RHEA:31427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exo-alpha-bergamotene synthase"
RHEA:31427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (1S,5S,6R)-alpha-bergamotene + diphosphate
RHEA:31427	skos:prefLabel	"exo-alpha-bergamotene synthase"
RHEA:31427	skos:altLabel	"trans-alpha-bergamotene synthase"
GO:0110035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rDNA spacer replication fork barrier binding, bending
RHEA:12019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-germacrene D + diphosphate
RHEA:71341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-tyrosine(in) + 2 Na(+)(in) => chloride(out) + L-tyrosine(out) + 2 Na(+)(out)
RHEA:46830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
RHEA:48670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-73932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resynthesis of excised residue by POLB (Mus musculus)
RHEA:72561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(in) + pentanoate(out) => estrone 3-sulfate(out) + pentanoate(in)
REACT:R-XTR-173745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3(H2O)-bound Factor B (Xenopus tropicalis)
REACT:R-BTA-9645524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose binds TIFA (Bos taurus)
REACT:R-BTA-1671687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR activation (Bos taurus)
REACT:R-HSA-5601888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown nuclease cleaves pre-piRNA in 4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH (Homo sapiens)
RHEA:41427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 <=> formate + grixazone A + H(+) + 3 H2O
RHEA:40344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanedioyl-CoA + CoA => acetyl-CoA + tetradecanedioyl-CoA
REACT:R-HSA-375149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with GFRalpha-1 (Homo sapiens)
REACT:R-CFA-6805730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD9 methylates TP53 (Canis familiaris)
REACT:R-PFA-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Plasmodium falciparum)
REACT:R-HSA-189457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial intermembrane PRIN9 translocates to mitochondrial matrix (Homo sapiens)
RHEA:16957	skos:prefLabel	"3',5'-cyclic-GMP phosphodiesterase"
RHEA:16957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP + H2O = GMP + H(+)
RHEA:16957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3',5'-cyclic-GMP phosphodiesterase"
REACT:R-CFA-373358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR6 binds CXCL16 ligand (Canis familiaris)
REACT:R-SPO-8941234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Schizosaccharomyces pombe)
REACT:R-GGA-190263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3b binds to FGF (Gallus gallus)
REACT:R-BTA-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Bos taurus)
REACT:R-BTA-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)
REACT:R-DDI-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Dictyostelium discoideum)
REACT:R-HSA-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Homo sapiens)
REACT:R-MMU-9714481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the ER membrane (Mus musculus)
REACT:R-XTR-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Xenopus tropicalis)
RHEA:65448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + ethanol = CoA + ethyl butanoate
RHEA:38762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-XTR-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Xenopus tropicalis)
REACT:R-DRE-9009308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 polyubiquitinates RUNX2 (Danio rerio)
REACT:R-BTA-176588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + PAPS => lithocholate sulfate + PAP (Bos taurus)
REACT:R-GGA-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Gallus gallus)
RHEA:60179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O <=> 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate
RHEA:28176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	colneleate + H2O => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate
REACT:R-HSA-400097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-beta:G-gamma inhibits Adenylate cyclase (Homo sapiens)
RHEA:18288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-aspartate + H2O <=> a carboxylate + D-aspartate
RHEA:21408	skos:altLabel	"L-phenylalanine dehydrogenase"
RHEA:21408	skos:prefLabel	"phenylalanine dehydrogenase"
RHEA:21408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine dehydrogenase"
RHEA:21408	skos:altLabel	"PheDH"
RHEA:21408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-phenylalanine + NAD(+) = 3-phenylpyruvate + H(+) + NADH + NH4(+)
REACT:R-RNO-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Rattus norvegicus)
REACT:R-SSC-5668543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3:NIK binds TRAF2:cIAP1/2 (Sus scrofa)
RHEA:52029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonyl-L-amino acid + H2O => a jasmonate + an L-alpha-amino acid
REACT:R-HSA-6787591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 (Homo sapiens)
REACT:R-RNO-5689630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BAP1-interacting complex (Rattus norvegicus)
REACT:R-XTR-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Xenopus tropicalis)
GO:0005140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-9 receptor binding
GO:0005140	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-9
GO:0005140	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-9 receptor ligand
REACT:R-BTA-8956026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL9:RBX1 ubiquitinates BIRC5 (Bos taurus)
RHEA:10526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + succinate semialdehyde => 2-oxoglutarate + H(+)
REACT:R-BTA-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Bos taurus)
RHEA:22750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate
REACT:R-SSC-9709831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds TBK1 and IRF3 (Sus scrofa)
RHEA:52294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-432096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated integrin alphaIIb beta3 binds SHC1 (Drosophila melanogaster)
REACT:R-DME-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Drosophila melanogaster)
REACT:R-XTR-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Xenopus tropicalis)
RHEA:49020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide
GO:0047901	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyl coenzyme A hydrolase activity
GO:0047901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA hydrolase activity
REACT:R-HSA-5617037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Homo sapiens)
REACT:R-RNO-9667952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 is deacetylated by SIRT2 (Rattus norvegicus)
RHEA:48219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-CFA-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Canis familiaris)
RHEA:37437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate
REACT:R-SSC-111238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR2  homodimer (Sus scrofa)
REACT:R-GGA-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Gallus gallus)
REACT:R-XTR-380303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Phospho-Nlp from the centrosome (Xenopus tropicalis)
RHEA:48983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dichlorocatechol + O2 <=> (2Z,4Z)-2,3-dichloromuconate + 2 H(+)
REACT:R-SSC-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)
REACT:R-GGA-388468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR1A,B (Gallus gallus)
REACT:R-MMU-5676607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF,sAPRIL binds TACI,BCMA (Mus musculus)
RHEA:18018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-pyruvate => CO2 + indole-3-acetaldehyde
REACT:R-MMU-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Mus musculus)
RHEA:63480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H(+) + NADPH
GO:0018752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epsilon-caprolactam lactamase activity
RHEA:11911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nonane-4,6-dione <=> butanoate + H(+) + pentan-2-one
REACT:R-XTR-9692539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds HRH1 inverse agonists (Xenopus tropicalis)
REACT:R-CEL-2396395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) binds alpha-dystroglycan (Caenorhabditis elegans)
REACT:R-SSC-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Sus scrofa)
RHEA:25037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)
RHEA:25037	skos:altLabel	"PSTK"
RHEA:25037	skos:prefLabel	"O-phosphoseryl-tRNA(Sec) kinase"
RHEA:25037	skos:altLabel	"L-seryl-tRNA(Sec) kinase"
RHEA:25037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-phosphoseryl-tRNA(Sec) kinase"
RHEA:10583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate
REACT:R-HSA-9657791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-144 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)
REACT:R-RNO-6804596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1:CYCS binds APIP (Rattus norvegicus)
RHEA:60227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate
RHEA:47423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + glutaryl-CoA <=> (2E)-glutaconyl-CoA + AH2
REACT:R-PFA-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Plasmodium falciparum)
REACT:R-RNO-9036987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Rattus norvegicus)
RHEA:29733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-maltose(out) => beta-maltose(in)
RHEA:40282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + dodecanoyl-CoA <=> CoA + O-dodecanoyl-R-carnitine
REACT:R-RNO-6810392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMEM55B translocates to the nucleus (Rattus norvegicus)
REACT:R-DRE-4641147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DACT1 binds DVL2 (Danio rerio)
REACT:R-HSA-5617096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective POMGNT1 does not transfer GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Homo sapiens)
RHEA:28094	skos:altLabel	"C55-isoprenyl diphosphatase"
RHEA:28094	skos:prefLabel	"undecaprenyl-diphosphate phosphatase"
RHEA:28094	skos:altLabel	"C55-isoprenyl pyrophosphatase"
RHEA:28094	skos:altLabel	"undecaprenyl-diphosphatase"
RHEA:28094	skos:altLabel	"undecaprenyl pyrophosphate pyrophosphatase"
RHEA:28094	skos:altLabel	"isoprenyl pyrophosphatase"
RHEA:28094	skos:altLabel	"undecaprenyl-diphosphate phosphohydrolase"
RHEA:28094	skos:altLabel	"UPP phosphatase"
RHEA:28094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"undecaprenyl-diphosphate phosphatase"
RHEA:28094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate
RHEA:28094	skos:altLabel	"undecaprenyl pyrophosphate phosphatase"
REACT:R-DME-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Drosophila melanogaster)
REACT:R-CEL-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)
REACT:R-GGA-6787533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Gallus gallus)
RHEA:62070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => 2-deoxy-D-glucose 6-phosphate + NADP(+)
REACT:R-BTA-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Bos taurus)
REACT:R-SSC-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Sus scrofa)
RHEA:10531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:38689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate => (4R)-hydroxysphinganine(in) + ATP + H2O
RHEA:29527	skos:altLabel	"Alg3 alpha-1,3-mannosyl transferase"
RHEA:29527	skos:altLabel	"Dol-P-Man:Man5GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase"
RHEA:29527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:29527	skos:altLabel	"Man5GlcNAc2-PP-Dol mannosyltransferase"
RHEA:29527	skos:prefLabel	"dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase"
RHEA:29527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase"
RHEA:43258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O
GO:0015551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenyl propanoate transmembrane transporter activity
GO:0015551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenyl propionate transmembrane transporter activity
RHEA:50313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + H(+) => butanal + CO2
REACT:R-DRE-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Danio rerio)
GO:0031870	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thromboxane A2 receptor ligand
GO:0031870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostanoid TP receptor binding
GO:0031870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thromboxane A2 receptor binding
REACT:R-MMU-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Mus musculus)
REACT:R-DDI-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Dictyostelium discoideum)
GO:0022824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmitter-gated ion channel activity
GO:0022824	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ionotropic neurotransmitter receptor activity
REACT:R-HSA-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
RHEA:33993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-copaene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:54642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12E)-labda-8(17),12,14-triene + diphosphate => (+)-copalyl diphosphate
REACT:R-RNO-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Rattus norvegicus)
REACT:R-RNO-5624492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK phosphorylates p21 RAF1 on S338 (Rattus norvegicus)
REACT:R-CEL-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Caenorhabditis elegans)
REACT:R-SPO-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Schizosaccharomyces pombe)
REACT:R-DRE-8935732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds SIN3A,(SIN3B) co-repressor (Danio rerio)
REACT:R-GGA-5685985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Gallus gallus)
REACT:R-MMU-73598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Mus musculus)
REACT:R-DME-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Drosophila melanogaster)
RHEA:50725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxyphenylacetaldehyde oxime => (Z)-(4-hydroxyphenyl)acetaldehyde oxime
REACT:R-BTA-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Bos taurus)
REACT:R-HSA-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
RHEA:60061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP
RHEA:31802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-aminomethyl-2-methylpyrimidine + H2O <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)
REACT:R-RNO-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Rattus norvegicus)
RHEA:66414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + glutathione(in) + H2O + taurochenodeoxycholate(in)
REACT:R-XTR-5687088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates MAPKAPK5 (Xenopus tropicalis)
RHEA:18074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + A => AH2 + orotate
REACT:R-PFA-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Plasmodium falciparum)
RHEA:53784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-muricholate + deoxycholoyl-CoA = beta-muricholoyl-CoA + deoxycholate
GO:0044025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H2B-S14 specific)
GO:0044025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-serine kinase activity (H2B-S14 specific)
GO:0044025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2BS14 kinase activity
GO:0044025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serine kinase activity (H2B-S14 specific)
REACT:R-MMU-9687828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-GlcNAcylation of RIPK3 (TLR4 signaling) (Mus musculus)
REACT:R-HSA-5649883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB-mediated DNA strand displacement synthesis (Homo sapiens)
REACT:R-CFA-6787820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds CSF1R (Canis familiaris)
REACT:R-CEL-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)
REACT:R-GGA-3900070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MKL1 with SUMO1 (Gallus gallus)
RHEA:42139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine
GO:0008666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrodipicolinate N-succinyltransferase activity
GO:0008666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
GO:0008666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity
GO:0008666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
GO:0008666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THDP N-succinyltransferase activity
GO:0008666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydropicolinate succinylase activity
GO:0008666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
GO:0008666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrodipicolinate succinyltransferase activity
GO:0008666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrodipicolinate succinylase activity
REACT:R-HSA-9707505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to CLEC1B dimer (Homo sapiens)
RHEA:62865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine
RHEA:41674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-sn-glycerol + ATP
REACT:R-HSA-389622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Homo sapiens)
REACT:R-GGA-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Gallus gallus)
REACT:R-HSA-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Homo sapiens)
RHEA:10338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate => citrate
RHEA:15173	skos:prefLabel	"NADPH peroxidase"
RHEA:15173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + NADPH = 2 H2O + NADP(+)
RHEA:15173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADPH peroxidase"
RHEA:36954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 <=> (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Drosophila melanogaster)
REACT:R-RNO-2730833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)
REACT:R-MMU-5618328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAT acetylates microtubules (Mus musculus)
REACT:R-HSA-5625901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)
REACT:R-XTR-71588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Xenopus tropicalis)
RHEA:64501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine => 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine
RHEA:41628	skos:prefLabel	"cyclooctat-9-en-7-ol synthase"
RHEA:41628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclooctat-9-en-7-ol synthase"
RHEA:41628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + H2O = cyclooctat-9-en-7-ol + diphosphate
GO:0106302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0106302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonic acid 8,9-epoxygenase activity
REACT:R-GGA-68918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK and DDK associate with the Mcm10:pre-replicative complex (Gallus gallus)
RHEA:46428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]
REACT:R-HSA-9695838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of FLT3 mutants (Homo sapiens)
REACT:R-SSC-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Sus scrofa)
REACT:R-DRE-5624130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylated NPHP3 translocates into the ciliary membrane (Danio rerio)
RHEA:50817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADPH => 5alpha-androstan-3,17-dione + NADP(+)
REACT:R-CFA-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Canis familiaris)
REACT:R-CFA-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Canis familiaris)
REACT:R-BTA-170153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Bos taurus)
RHEA:63910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + pravastatin(out) => ATP + H2O + pravastatin(in)
RHEA:64683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + ethanol <=> CoA + ethyl benzoate
RHEA:40110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-PFA-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Plasmodium falciparum)
RHEA:11627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(hydroxyimino)propanoate + acetone <=> acetone oxime + pyruvate
RHEA:69451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> delta-cadinol + diphosphate
REACT:R-CFA-390251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)
REACT:R-GGA-9709406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to Cytochrome c oxidase (Gallus gallus)
GO:0034958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminohydroquinone monooxygenase activity
REACT:R-GGA-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Gallus gallus)
REACT:R-BTA-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Bos taurus)
RHEA:66951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA
REACT:R-DME-192475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Drosophila melanogaster)
RHEA:25821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermidine => 4-aminobutanal + H2O2 + propane-1,3-diamine
REACT:R-DME-5654679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR3 (Drosophila melanogaster)
GO:0035005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase activity, class I
GO:0035005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II phosphoinositide 3-kinase activity
GO:0035005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity
GO:0035005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	C2-domain-containing phosphoinositide 3-kinase activity
GO:0035005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase, class I, catalyst activity
GO:0035005	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase activity, class II
REACT:R-HSA-981665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binding protein binds Protein S (Homo sapiens)
REACT:R-CFA-6793590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT2 transfers octanoyl group to GCSH (Canis familiaris)
REACT:R-HSA-5423728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFXBO translocates from cytosol to nucleoplasm (Homo sapiens)
REACT:R-DDI-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Dictyostelium discoideum)
GO:1990749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polynucleotide adenylyltransferase activator activity
RHEA:41461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacylglycerol + a sphingomyelin
REACT:R-SSC-198266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)
EC:3.2.1.61	skos:prefLabel	"mycodextranase"
EC:3.2.1.61	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycodextranase"
RHEA:20394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[citrate lyase ACP] + S-acetylphosphopantotheine => (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]
RHEA:54234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-dioctanoyl-sn-glycerol + CDP-choline
RHEA:52528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparagine = 2-oxosuccinamate + L-glutamate
RHEA:11105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine => H(+) + hercynine + S-adenosyl-L-homocysteine
REACT:R-SSC-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)
RHEA:47363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoate ester + H2O <=> an aliphatic alcohol + decanoate + H(+)
REACT:R-CEL-8944261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIII (Caenorhabditis elegans)
RHEA:52416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-O-phospho-D-erythronate + H(+) = CO2 + dihydroxyacetone phosphate
REACT:R-BTA-451056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Microtubule-independent trafficking of connexons to the plasma membrane (Bos taurus)
RHEA:43847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 <=> (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)
RHEA:38236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + octadecan-1-ol => 1-O-octadecyl (9Z)-octadecenoate + CoA
REACT:R-DRE-5579018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1(868-1441) binds PAX3(1-319) (Danio rerio)
RHEA:70401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosanoyl-3-oxosphinganine => 3-oxosphinganine + tetracosanoyl-CoA
REACT:R-CFA-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Canis familiaris)
REACT:R-XTR-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)
REACT:R-CEL-5674132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Caenorhabditis elegans)
REACT:R-DDI-4551604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO1 (Dictyostelium discoideum)
REACT:R-RNO-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Rattus norvegicus)
RHEA:51841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauroallocholate(out) => 2 Na(+)(in) + tauroallocholate(in)
REACT:R-MMU-5674366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RD binds p-2S MAP2Ks and MAPKs (Mus musculus)
RHEA:32505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => linalool + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:54496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate = diphosphate + ent-atiserene
RHEA:54496	skos:prefLabel	"ent-atiserene synthase"
RHEA:54496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-atiserene synthase"
REACT:R-RNO-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Rattus norvegicus)
RHEA:20770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + phosphonoacetaldehyde => 3-phosphonopyruvate + H(+)
REACT:R-BTA-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Bos taurus)
REACT:R-RNO-193964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 21-hydroxylates PROG (Rattus norvegicus)
RHEA:42032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-dimethyl-L-lysine(36) demethylase"
RHEA:42032	skos:altLabel	"H3-K36-specific demethylase"
RHEA:42032	skos:altLabel	"[histone-H3]-lysine-36 demethylase"
RHEA:42032	skos:altLabel	"JmjC domain-containing histone demethylase 1A"
RHEA:42032	skos:prefLabel	"[histone H3]-dimethyl-L-lysine(36) demethylase"
RHEA:42032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate
RHEA:42032	skos:altLabel	"histone demethylase"
RHEA:42032	skos:altLabel	"histone-lysine (H3-K36) demethylase"
RHEA:42032	skos:altLabel	"JHDM1A"
REACT:R-HSA-5262921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) (Homo sapiens)
REACT:R-XTR-3000112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Xenopus tropicalis)
RHEA:70742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Danio rerio)
REACT:R-MMU-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Mus musculus)
REACT:R-BTA-1504186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL recruits GSK3beta:AXIN1 to the receptor complex (Bos taurus)
REACT:R-MMU-4551721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VHL with SUMO1 (Mus musculus)
REACT:R-SSC-8944214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type I (Sus scrofa)
REACT:R-BTA-2730864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TRAF6 to CBM complex by binding to MALT1 (Bos taurus)
RHEA:12208	skos:altLabel	"esterase D"
RHEA:12208	skos:prefLabel	"methylumbelliferyl-acetate deacetylase"
RHEA:12208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylumbelliferyl-acetate deacetylase"
RHEA:12208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)
REACT:R-SSC-2730840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Sus scrofa)
REACT:R-BTA-8938076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD38 hydrolyses NAD+ to NAM and ADP-ribose (Bos taurus)
RHEA:67813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]
REACT:R-DRE-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Danio rerio)
RHEA:35153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH => 4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+)
REACT:R-BTA-532603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin mediated activation of N-WASP (Bos taurus)
REACT:R-MMU-9645524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose binds TIFA (Mus musculus)
REACT:R-GGA-419254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate (Gallus gallus)
REACT:R-RNO-200143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)
RHEA:69588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + UMP = IMP + uridine
RHEA:30536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinate sulfoxide + H(+) + NADPH => biotin + H2O + NADP(+)
RHEA:50370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+) => 2-methylbutan-2-ol + H(+) + NADPH + O2
RHEA:40838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine
REACT:R-RNO-204008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC31:SEC13 and v-SNARE recruitment (Rattus norvegicus)
RHEA:69871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate 5-semialdehyde = (S)-1-pyrroline-5-carboxylate + H(+) + H2O
RHEA:58514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH
RHEA:36282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NAD(+)
REACT:R-BTA-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Bos taurus)
REACT:R-XTR-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Xenopus tropicalis)
RHEA:63115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ascofuranol <=> AH2 + ascofuranone
REACT:R-HSA-141139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of TRAIL:TRAIL receptor complex (Homo sapiens)
GO:0140034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylation-dependent protein binding
RHEA:62686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + rubrofusarin + S-adenosyl-L-homocysteine => norrubrofusarin + S-adenosyl-L-methionine
REACT:R-CFA-1855176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Canis familiaris)
REACT:R-HSA-9724670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds imiquimod (Homo sapiens)
REACT:R-CFA-110221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by SMUG1 glycosylase (Canis familiaris)
REACT:R-XTR-5635845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind CDC73 (Xenopus tropicalis)
REACT:R-SSC-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)
RHEA:33187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-RNO-983421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Journey of cargo through Golgi complex (Rattus norvegicus)
GO:0033838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol-3-O-glucoside glucosyltransferase activity
GO:0033838	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity
RHEA:72454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) <=> a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)
GO:0047024	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dehydrogenase, 3beta,20alpha-hydroxy steroid
GO:0047024	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3beta(or 20alpha)-hydroxysteroid dehydrogenase activity
GO:0047024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO:0047024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	progesterone reductase activity
GO:0047024	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3beta,20alpha-hydroxysteroid oxidoreductase activity
GO:0047024	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity
GO:0047024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-beta-HSD activity
GO:0047024	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity
RHEA:58392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-PFA-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Plasmodium falciparum)
REACT:R-MMU-2467798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTTG1 (Securin) sequesters ESPL1 (Separase) (Mus musculus)
RHEA:59241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + L-lysine => L-homoarginine + L-ornithine
REACT:R-RNO-9033516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)
RHEA:35154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) <=> (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH
REACT:R-MMU-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Mus musculus)
RHEA:47821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)
GO:0033946	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xyloglucan endo-beta-1,4-glucanase activity
GO:0033946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xyloglucan-specific endo-beta-1,4-glucanase activity
GO:0033946	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1,4-beta-D-glucan glucanohydrolase activity
GO:0033946	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity
GO:0033946	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	XH
GO:0033946	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xyloglucanase activity
GO:0033946	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	XEG
GO:0033946	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xyloglucanendohydrolase activity
RHEA:62100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
REACT:R-SSC-1605736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Sus scrofa)
GO:0043749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:phenol:water phosphotransferase activity
GO:0043749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenol, water dikinase activity
GO:0043749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylphosphate synthase activity
GO:0043749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenol:water dikinase activity
REACT:R-RNO-5423678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)
RHEA:27415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + morphine + succinate => 2-oxoglutarate + codeine + O2
REACT:R-DDI-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Dictyostelium discoideum)
REACT:R-MMU-173488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)
RHEA:20085	skos:prefLabel	"flavonol-3-O-beta-glucoside O-malonyltransferase"
RHEA:20085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucoside + malonyl-CoA = a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA
RHEA:20085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonol-3-O-beta-glucoside O-malonyltransferase"
REACT:R-CFA-2559568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Canis familiaris)
REACT:R-RNO-444476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPRL2 receptor binds a wide range of ligands (Rattus norvegicus)
RHEA:49458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate => (2S)-2-amino-4-deoxychorismate + H2O
REACT:R-SSC-186826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to the active receptor (Sus scrofa)
REACT:R-CFA-2028679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Canis familiaris)
REACT:R-BTA-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Bos taurus)
REACT:R-CFA-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Canis familiaris)
RHEA:20453	skos:prefLabel	"scopoletin glucosyltransferase"
RHEA:20453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scopoletin glucosyltransferase"
RHEA:20453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scopoletin + UDP-alpha-D-glucose = H(+) + scopolin + UDP
REACT:R-GGA-266328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Gallus gallus)
REACT:R-HSA-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Homo sapiens)
RHEA:34980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) => H(+)(out)
REACT:R-XTR-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Xenopus tropicalis)
REACT:R-RNO-3000383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I, HDAC7 SUMOylate PML with SUMO1 (Rattus norvegicus)
REACT:R-MMU-450580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 (hnRNP D0) is ubiquitinylated (Mus musculus)
REACT:R-DDI-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Dictyostelium discoideum)
REACT:R-RNO-73646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)
REACT:R-HSA-8938228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter (Homo sapiens)
REACT:R-SSC-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Sus scrofa)
RHEA:48233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-glutamate 5-semialdehyde => CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde
RHEA:65779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-6811504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 dephosphorylation by PP2A-B56-beta,gamma (Danio rerio)
RHEA:39415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)
REACT:R-CFA-5676597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)
RHEA:72326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + thiosulfate(out) <=> 3 Na(+)(in) + thiosulfate(in)
REACT:R-SSC-3149518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRR reduces cob(II)alamin to meCbl (Sus scrofa)
RHEA:43293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
REACT:R-HSA-9632038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)
REACT:R-DRE-975139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Danio rerio)
REACT:R-GGA-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Gallus gallus)
REACT:R-DRE-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Danio rerio)
RHEA:45412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2
REACT:R-HSA-392852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)
REACT:R-DME-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)
REACT:R-MMU-443779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Linkage of L1 with treadmilling F-actin (Mus musculus)
REACT:R-HSA-5690196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates RNF128 (Homo sapiens)
REACT:R-SSC-8938108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds cathepsin L (Sus scrofa)
REACT:R-CFA-209792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylation of serotonin (Canis familiaris)
REACT:R-SSC-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Sus scrofa)
REACT:R-DME-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Drosophila melanogaster)
REACT:R-CFA-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Canis familiaris)
RHEA:40217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + H2O2 => FADH2 + O2
REACT:R-GGA-158756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Gallus gallus)
REACT:R-SSC-9656891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1SW binds 11cRAL (Sus scrofa)
RHEA:10857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP
REACT:R-HSA-877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of JAKs by PTPs (Homo sapiens)
RHEA:40173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H2O2 => dodecanoyl-CoA + O2
REACT:R-HSA-9638156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBFOX3 (NeuN) gene expression is stimulated by NPAS4 (Homo sapiens)
REACT:R-HSA-8942075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxynitrite and carbon dioxide react to nitrosoperoxycarbonate (Homo sapiens)
REACT:R-MMU-5676940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Mus musculus)
REACT:R-HSA-204549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caveolin-1 binds Basigin (Homo sapiens)
RHEA:64772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol
REACT:R-CEL-450333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
RHEA:38425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O
RHEA:41495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine
RHEA:34028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH
REACT:R-DRE-3000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BORA binds PLK1 and AURKA (Danio rerio)
REACT:R-MMU-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Mus musculus)
RHEA:53315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-73920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Danio rerio)
REACT:R-MMU-174367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCL ligates L-Glu to L-Cys (Mus musculus)
RHEA:30228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O => dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)
REACT:R-HSA-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Homo sapiens)
GO:0035798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH:2-alkenal alpha,beta-hydrogenase activity
GO:0035798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-alkenal reductase (NADP+) activity
REACT:R-CEL-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Caenorhabditis elegans)
RHEA:11007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + salicylate <=> catechol + CO2 + H2O + NAD(+)
RHEA:39856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol
REACT:R-RNO-74746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y427-SHC1 (Rattus norvegicus)
RHEA:65075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> dauca-4,7-diene + diphosphate
RHEA:69029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrotestosterone + H(+) + NADPH => 5beta-androstane-3alpha,17beta-diol + NADP(+)
REACT:R-DME-9021627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
GO:0031763	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	galanin receptor ligand
GO:0031763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galanin receptor binding
RHEA:19204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + ATP <=> ADP + dGMP + H(+)
REACT:R-CFA-398185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG binds plexin B1 (Canis familiaris)
RHEA:19670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O => GDP + H(+) + phosphate
RHEA:57333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 3 O2 + 3 propionate 3-nitronate => 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite
GO:0102699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropionitrile hydroxylase activity
REACT:R-HSA-9034796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds PLCG1 (Homo sapiens)
RHEA:54906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-[ACP] + NAD(+) => (2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH
REACT:R-CFA-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)
REACT:R-MMU-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Mus musculus)
REACT:R-RNO-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Rattus norvegicus)
REACT:R-SSC-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Sus scrofa)
RHEA:36633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+) => D-ribulose 1,5-bisphosphate + O2
REACT:R-RNO-71286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)
REACT:R-MMU-8855564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Mus musculus)
RHEA:12128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:12128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate synthase (ferredoxin)"
RHEA:12128	skos:altLabel	"ferredoxin-dependent glutamate synthase"
RHEA:12128	skos:prefLabel	"glutamate synthase (ferredoxin)"
RHEA:10351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline + ATP + 2 H2O <=> ADP + H(+) + L-glutamate + phosphate
RHEA:35293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisopentadecanoyl-CoA + CO2 + CoA => 11-methyldodecanoyl-CoA + H(+) + malonyl-CoA
RHEA:65821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Canis familiaris)
REACT:R-HSA-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Homo sapiens)
REACT:R-DME-191422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate-5-phosphate is further phosphorylated. (Drosophila melanogaster)
RHEA:66152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + noradrenaline = CoA + H(+) + N-acetylnoradrenaline
REACT:R-HSA-8868573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5:p25 phosphorylates PRDX2 (Homo sapiens)
REACT:R-CFA-5686900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 recruits DCLRE1C to ATM (Canis familiaris)
REACT:R-HSA-1227964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 homodimerization (Homo sapiens)
RHEA:22192	skos:altLabel	"AICAR transformylase"
RHEA:22192	skos:altLabel	"5-amino-4-imidazolecarboxamide ribonucleotide transformylase"
RHEA:22192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosylaminoimidazolecarboxamide formyltransferase"
RHEA:22192	skos:altLabel	"aminoimidazolecarboxamide ribonucleotide transformylase"
RHEA:22192	skos:altLabel	"AICAR formyltransferase"
RHEA:22192	skos:altLabel	"5-amino-4-imidazolecarboxamide ribotide transformylase"
RHEA:22192	skos:altLabel	"5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase"
RHEA:22192	skos:altLabel	"5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase"
RHEA:22192	skos:prefLabel	"phosphoribosylaminoimidazolecarboxamide formyltransferase"
RHEA:22192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
RHEA:22192	skos:altLabel	"10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase"
REACT:R-XTR-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Xenopus tropicalis)
REACT:R-XTR-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Xenopus tropicalis)
RHEA:63427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-phospholactate + GTP + H(+) <=> (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate
RHEA:24901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 GTP <=> 3',3'-c-di-GMP + 2 diphosphate
RHEA:27282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase"
RHEA:27282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)
RHEA:27282	skos:prefLabel	"2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase"
REACT:R-BTA-9009488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 binds CSF1 (Bos taurus)
REACT:R-BTA-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)
REACT:R-HSA-451345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM binds DCC (Homo sapiens)
RHEA:35279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hexadecanoyl-CoA = 3-oxooctadecanoyl-CoA + CoA
REACT:R-GGA-391152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds PTK2B (Gallus gallus)
RHEA:15117	skos:prefLabel	"triphosphoribosyl-dephospho-CoA synthase"
RHEA:15117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"triphosphoribosyl-dephospho-CoA synthase"
RHEA:15117	skos:altLabel	"2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase"
RHEA:15117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine
RHEA:49249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol(out) + N(pros)-phospho-L-histidyl-[protein] => galactitol 1-phosphate(in) + L-histidyl-[protein]
REACT:R-DME-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Drosophila melanogaster)
GO:0017022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myosin phosphatase myosin binding
GO:0017022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin binding
REACT:R-BTA-174441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Bos taurus)
REACT:R-RNO-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)
REACT:R-HSA-2024108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some HSPGs are secreted to the plasma membrane (Homo sapiens)
RHEA:69454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+) => 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH
REACT:R-SSC-5658438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRED dimer binds NF1 (Sus scrofa)
REACT:R-MMU-5682965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Mus musculus)
REACT:R-GGA-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)
REACT:R-XTR-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Xenopus tropicalis)
REACT:R-SSC-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Sus scrofa)
RHEA:42676	skos:prefLabel	"L-cysteinyl-L-histidinylsulfoxide synthase"
RHEA:42676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-cysteinyl-L-histidinylsulfoxide synthase"
RHEA:42676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + L-histidine + O2 = H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide
RHEA:10305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]
REACT:R-SSC-9749583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Sus scrofa)
GO:0106386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity
RHEA:25337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinyl-tRNA(Cys) <=> H(+) + L-cysteine + tRNA(Cys)
REACT:R-HSA-6798667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDH tetramer oxidises L-Thr to 2A-3OB (Homo sapiens)
REACT:R-RNO-6786652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIT1 hydrolyses CHIT to 3xADGP (Rattus norvegicus)
RHEA:51439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-alanine <=> (2R)-2-amino-4-oxopentanoate + CoA
RHEA:67743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-neuraminate <=> aceneuramate
RHEA:15199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine
RHEA:66250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + IC-asc-C9-CoA => CoA + IC-asc-C9-AMP
RHEA:66653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => african-1-ene + diphosphate
RHEA:43883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA <=> (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate
RHEA:62630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + H2O + NAD(+) => a hydroperoxide + H(+) + NADH
REACT:R-MMU-1855169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)
RHEA:10350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-glutamate + phosphate => 5-oxo-L-proline + ATP + 2 H2O
RHEA:43882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate => (25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA
REACT:R-CEL-8864125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)
REACT:R-SSC-374214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CXCR4 and 7 bind CXCL12 ligand (Sus scrofa)
GO:0160003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mono-ADP-D-ribose modification-dependent protein binding
REACT:R-XTR-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Xenopus tropicalis)
REACT:R-DME-8871376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds PI3P (Drosophila melanogaster)
REACT:R-SSC-192054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Sus scrofa)
REACT:R-HSA-9036070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GUSB does not hydrolyse CS/HS precursor (Homo sapiens)
REACT:R-GGA-606287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSF complex binds the centromere (Gallus gallus)
REACT:R-MMU-9009485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34:CSF1 binds CSF1R (Mus musculus)
REACT:R-HSA-1013833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cables link CDK5 and ABL1 (Homo sapiens)
REACT:R-CFA-450971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Canis familiaris)
REACT:R-BTA-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)
REACT:R-HSA-166038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-bound CD14 binds LPS (Homo sapiens)
REACT:R-RNO-1364044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR:JAK2 dimerizes (Rattus norvegicus)
RHEA:45641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:22420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxymuconic-semialdehyde dehydrogenase"
RHEA:22420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) = 2 H(+) + maleylacetate + NADH
RHEA:22420	skos:prefLabel	"4-hydroxymuconic-semialdehyde dehydrogenase"
REACT:R-SCE-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Saccharomyces cerevisiae)
REACT:R-RNO-191062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of Klotho-bound FGFR1c (Rattus norvegicus)
REACT:R-HSA-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Homo sapiens)
RHEA:67291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine <=> (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine
REACT:R-SSC-210294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-2 (Sus scrofa)
RHEA:34001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholesta-7,24-dien-3beta-ol => zymosterol
RHEA:20790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-beta-D-ribose 1''-phosphate + H(+) + nicotinamide => NAD(+) + phosphate
RHEA:54342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine
RHEA:41264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prostaglandin A1 => 15-oxo-prostaglandin A1 + H(+) + NADH
RHEA:70974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-dopa + H2O + O2 <=> 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)
REACT:R-SCE-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Saccharomyces cerevisiae)
RHEA:20358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + H(+) + NADH + O2 => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)
REACT:R-BTA-8964284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in active Gq-BTK complex is activated (Bos taurus)
REACT:R-HSA-6797245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FASLG (Homo sapiens)
REACT:R-XTR-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Xenopus tropicalis)
REACT:R-DRE-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Danio rerio)
RHEA:66655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> african-1-ene + diphosphate
REACT:R-RNO-203567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylation of eNOS (Rattus norvegicus)
REACT:R-CEL-6814885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBCAP complex binds 7-methylguanosine cap of snRNA (Caenorhabditis elegans)
REACT:R-HSA-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
REACT:R-RNO-193737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Rattus norvegicus)
RHEA:65576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate = an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP
RHEA:47141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0001072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA binding transcription antitermination factor activity
GO:0001072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription antitermination factor activity, RNA binding
RHEA:16243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + H(+) + sucrose => an NDP-alpha-D-glucose + D-fructose
REACT:R-HSA-1989771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TNFRSF21 (Homo sapiens)
RHEA:33104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => alpha-muurolene + diphosphate
REACT:R-MMU-193684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 recruits an atypical PKC (Mus musculus)
REACT:R-GGA-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Gallus gallus)
REACT:R-CFA-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Canis familiaris)
REACT:R-GGA-430183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK binds PAK (Gallus gallus)
REACT:R-CFA-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Canis familiaris)
RHEA:64313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride + 2 FADH2 + 2 O2 + sulochrin => dihydrogeodin + 2 FAD + H(+) + 4 H2O
EC:3.4.22.25	skos:altLabel	"papaya peptidase B"
EC:3.4.22.25	skos:prefLabel	"glycyl endopeptidase"
EC:3.4.22.25	skos:altLabel	"papaya proteinase IV"
EC:3.4.22.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycyl endopeptidase"
RHEA:72857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(in) + dADP(out) => ADP(out) + dADP(in)
REACT:R-DME-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Drosophila melanogaster)
REACT:R-SSC-964759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alternative endo-mannosidase I route (Sus scrofa)
RHEA:56578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + H(+) + UDP => globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine
GO:0015114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphate transmembrane transporter activity
GO:0015114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) = phosphate(out)
GO:0015114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate ion transmembrane transporter activity
REACT:R-HSA-5654586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS binds GRB2:SOS1 (Homo sapiens)
REACT:R-RNO-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)
RHEA:61574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(11Z,13E)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2
RHEA:28682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-8 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-8
REACT:R-SCE-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Saccharomyces cerevisiae)
REACT:R-HSA-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Homo sapiens)
REACT:R-HSA-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Homo sapiens)
RHEA:38817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:28427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allulose 6-phosphate => keto-D-fructose 6-phosphate
REACT:R-GGA-6800298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF dimer binds MET (Gallus gallus)
REACT:R-CEL-446877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is K63 poly-ubiquitinated (Caenorhabditis elegans)
GO:0052867	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylinositol-trisphosphatase activity
GO:0052867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052867	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	triphosphoinositide phosphatase activity
GO:0052867	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PtdIns(1,4,5)P3 phosphatase activity
GO:0052867	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PtdIns(1,4,5)P(3) phosphatase activity
GO:0052867	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity
GO:0052867	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	triphosphoinositide phosphomonoesterase activity
GO:0052867	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylinositol 1,4,5-trisphosphate phosphatase activity
REACT:R-HSA-6799495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYCTK phosphorylates DGA to 3PDGA (Homo sapiens)
REACT:R-BTA-8855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR:DAB1 binds SH3KBP1 (Bos taurus)
RHEA:10639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NADP(+) <=> D-mannuronate + H(+) + NADPH
REACT:R-GGA-5624126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome bind ciliary cargo (Gallus gallus)
RHEA:21411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-phenylalanine + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH + NH4(+)
REACT:R-SSC-9667456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B bind desmopressin (Sus scrofa)
RHEA:55978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-sulfanylglutathione + sulfite => glutathione + thiosulfate
REACT:R-HSA-2730882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC-theta (Homo sapiens)
RHEA:54510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-heptaprene + diphosphate => all-trans-heptaprenyl diphosphate
REACT:R-BTA-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Bos taurus)
RHEA:21696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
RHEA:61367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dehydroepiandrosterone 3-sulfate(in) + H2O <=> ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate
RHEA:63492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menadione + NADPH = menadiol + NADP(+)
REACT:R-SSC-5693108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Sus scrofa)
RHEA:65687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine <=> a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine
REACT:R-SSC-377643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
REACT:R-MMU-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Mus musculus)
EC:2.3.1.182	skos:prefLabel	"(R)-citramalate synthase"
EC:2.3.1.182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-citramalate synthase"
REACT:R-HSA-169921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation and Folding of HA (Homo sapiens)
REACT:R-HSA-9705713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 dehydrogenates TEST to DHTEST (Homo sapiens)
REACT:R-GGA-1592398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP8 (Gallus gallus)
RHEA:70006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0004029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent aldehyde dehydrogenase activity
GO:0004029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked aldehyde dehydrogenase activity
GO:0004029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde:NAD+ oxidoreductase activity
GO:0004029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde dehydrogenase (NAD+)
GO:0004029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CoA-independent aldehyde dehydrogenase activity
GO:0004029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde dehydrogenase (NAD+) activity
GO:0004029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-aldehyde dehydrogenase activity
GO:0004029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionaldehyde dehydrogenase activity
GO:0004029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	m-methylbenzaldehyde dehydrogenase activity
GO:0004029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent 4-hydroxynonenal dehydrogenase activity
REACT:R-SSC-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)
RHEA:17293	skos:prefLabel	"precorrin-3B synthase"
RHEA:17293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"precorrin-3B synthase"
RHEA:17293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + precorrin-3A = H2O + NAD(+) + precorrin-3B
RHEA:17293	skos:altLabel	"precorrin-3X synthase"
RHEA:42287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
REACT:R-DME-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Drosophila melanogaster)
RHEA:20230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + ATP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + diphosphate
REACT:R-SCE-390304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => acetate + CoASH (Saccharomyces cerevisiae)
REACT:R-GGA-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Gallus gallus)
RHEA:27680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dCTP => ATP + dCDP
RHEA:70753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine
RHEA:70418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dihydroxyphenyl)acetyl-CoA + H2O <=> (3,5-dihydroxyphenyl)acetate + CoA + H(+)
RHEA:19979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate => 3'-phosphoadenylyl sulfate + L-tyrosine methyl ester
RHEA:51988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = 18S-resolvin E1
RHEA:22301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucoside + H(+) + UDP
RHEA:56099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal Gly-Gly + ATP + H(+) <=> [protein]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-BTA-2022378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Bos taurus)
REACT:R-XTR-77345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)
REACT:R-DRE-3465429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(S) and procaspase-8 form heterodimer (Danio rerio)
RHEA:29864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + GTP => ADP + GDP
RHEA:21913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + O2 + pyruvate => acetyl-CoA + CO2 + H2O2
REACT:R-DDI-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Dictyostelium discoideum)
REACT:R-HSA-8987080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Homo sapiens)
REACT:R-MMU-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Mus musculus)
EC:1.14.11.77	skos:altLabel	"2-oxoglutarate-dependent sulfate ester dioxygenase"
EC:1.14.11.77	skos:prefLabel	"alkyl sulfatase"
EC:1.14.11.77	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkyl sulfatase"
EC:1.14.11.77	skos:altLabel	"type II alkyl sulfatase"
EC:1.14.11.77	skos:altLabel	"alpha-ketoglutarate-dependent sulfate ester dioxygenase"
RHEA:40211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanedioyl-CoA + NAD(+) = 3-oxotetradecanedioyl-CoA + H(+) + NADH
REACT:R-SPO-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Schizosaccharomyces pombe)
EC:3.4.22.1	skos:altLabel	"cathepsin B1"
EC:3.4.22.1	skos:prefLabel	"cathepsin B"
EC:3.4.22.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin B"
GO:0102044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chlorobenzoate-4,5-oxygenase activity
RHEA:34184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose => alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)
EC:2.7.12.-	skos:prefLabel	"Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)"
EC:2.7.12.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)"
EC:2.7.1.74	skos:prefLabel	"deoxycytidine kinase"
EC:2.7.1.74	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxycytidine kinase"
REACT:R-MMU-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Mus musculus)
REACT:R-GGA-5653974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator binds Rag dimers (Gallus gallus)
REACT:R-SCE-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Saccharomyces cerevisiae)
GO:0030698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity
GO:0030698	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RUMT
GO:0050187	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	creatine phosphatase activity
GO:0050187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoamidase activity
GO:0050187	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphamide hydrolase activity
REACT:R-DRE-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Danio rerio)
RHEA:31631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate = phosphate + pseudaminate
RHEA:31631	skos:prefLabel	"pseudaminic acid synthase"
RHEA:31631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudaminic acid synthase"
RHEA:30376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-thujopsene + diphosphate
RHEA:48617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene D4 => glycine + leukotriene E4
RHEA:29544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:40136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + H2O => (9Z)-tetradecenoate + CoA + H(+)
RHEA:23541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu)
REACT:R-DRE-917888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF binds 2Fe3+ to form holoTF (Danio rerio)
REACT:R-BTA-2730889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)
REACT:R-XTR-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Xenopus tropicalis)
REACT:R-CEL-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Caenorhabditis elegans)
REACT:R-DRE-9749986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Danio rerio)
REACT:R-MMU-420582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin-1 trans heterodimer interaction (Mus musculus)
RHEA:63283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)
RHEA:10074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + H(+) + S-adenosyl-L-homocysteine => N,N-dimethylglycine + S-adenosyl-L-methionine
REACT:R-GGA-353460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1-Pol kappa complex formation (Gallus gallus)
REACT:R-CFA-76434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of carbon tetrachloride to form a free radical (Canis familiaris)
REACT:R-HSA-975175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyD88 interacts with the activated TLR receptor 7, 8 or 9  (Homo sapiens)
REACT:R-XTR-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Xenopus tropicalis)
REACT:R-DME-5654514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds FGFR1c (Drosophila melanogaster)
RHEA:41774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GQ1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E))
REACT:R-GGA-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Gallus gallus)
RHEA:32621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + sepiapterin => L-threo-7,8-dihydrobiopterin + NADP(+)
RHEA:17668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + octanoyl-[ACP] <=> H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]
RHEA:63084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + ilicicolin B + O2 = FAD + H(+) + 2 H2O + ilicicolin A
RHEA:23700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)
RHEA:23700	skos:prefLabel	"methenyltetrahydrofolate cyclohydrolase"
RHEA:23700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methenyltetrahydrofolate cyclohydrolase"
RHEA:52191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O
REACT:R-MMU-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Mus musculus)
RHEA:56490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-1606789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses DS (Homo sapiens)
GO:0072533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity
REACT:R-DRE-109387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Danio rerio)
RHEA:71433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)
RHEA:49335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-GGA-9706393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds ATP (Gallus gallus)
REACT:R-HSA-8851550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside diphosphates (Homo sapiens)
REACT:R-DME-8869627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NR to yield NMN (Drosophila melanogaster)
REACT:R-XTR-2065539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:Importin beta-1 dissociates (Xenopus tropicalis)
RHEA:66719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate <=> (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate
REACT:R-CEL-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Caenorhabditis elegans)
REACT:R-DRE-8856630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIDEA:CIDEC binds lipid droplets (Danio rerio)
GO:0061768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	magnesium:sodium antiporter activity
RHEA:32597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-3,7-dimethyloctanoate + H(+) => 7-isopropyl-4-methyloxepan-2-one + H2O
GO:0046028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity
GO:0046028	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plastocyanin
RHEA:64621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + acetyl-CoA => (E)-sinapoyl actetate + CoA
RHEA:13482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-methionine + tRNA(Met) => AMP + diphosphate + L-methionyl-tRNA(Met)
RHEA:48183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:19667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhex-2-enoyl-CoA + H(+) + NADH => 6-carboxyhexanoyl-CoA + NAD(+)
RHEA:34121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA
RHEA:59353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-lactose + O2 => H2O2 + lactobiono-1,5-lactone
REACT:R-DME-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)
REACT:R-DRE-373714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-Heterodimerization of nephrin and KIRREL (Danio rerio)
RHEA:35667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)
REACT:R-SSC-8848110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds activated PTK6 (Sus scrofa)
REACT:R-MMU-372705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of BCAR1 to PTK2 complex (Mus musculus)
GO:0062047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pipecolic acid N-hydroxylase
RHEA:46159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,9'-di-cis-phytofluene + a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + a plastoquinol
RHEA:29814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + thiamine(out) <=> ADP + H(+) + phosphate + thiamine(in)
REACT:R-XTR-190268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to Klotho-bound FGF23 (Xenopus tropicalis)
RHEA:25768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2-oxobutanoate + H(+) => 2-oxobutanoate + CO2
GO:0047605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-acetolactate decarboxylase activity
GO:0047605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]
GO:0047605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetolactate decarboxylase activity
GO:0047605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity
REACT:R-CFA-3781011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Canis familiaris)
REACT:R-DRE-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Danio rerio)
RHEA:43418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP
RHEA:37202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-BTA-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Bos taurus)
REACT:R-CFA-8866551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR binds components of the ERAD machinery for ubiquitination and degradation (Canis familiaris)
RHEA:41234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-RNO-211224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with DFF45 (Rattus norvegicus)
REACT:R-HSA-176585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Homo sapiens)
REACT:R-HSA-5684865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB dimer,C translocate from multivesicle body to lamellar body (Homo sapiens)
GO:0016298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipase activity
RHEA:11533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H2O + O2 => glyoxylate + H2O2 + NH4(+)
REACT:R-GGA-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Gallus gallus)
RHEA:72682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)
REACT:R-SSC-176101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Rad17-RFC complex to DNA (Sus scrofa)
REACT:R-MMU-8871227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA4 (Mus musculus)
REACT:R-RNO-4755478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates IKBKE with SUMO1 (Rattus norvegicus)
REACT:R-HSA-2220967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)
RHEA:53559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Schizosaccharomyces pombe)
RHEA:69536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-tagatopyranose 1-phosphate + ATP = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)
REACT:R-CEL-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Caenorhabditis elegans)
RHEA:14470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomuconate 6-semialdehyde + H2O + NAD(+) => (2Z,4E)-2-aminomuconate + 2 H(+) + NADH
RHEA:71821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-thyroxine(in) => L-thyroxine(out)
REACT:R-MMU-83650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FasL:Fas binds FADD (Mus musculus)
RHEA:25733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tetrahomomethionine
RHEA:40604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)
RHEA:15590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-4-hydroxyphenylglycine => 4-hydroxyphenylglyoxylate + L-glutamate
RHEA:26104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-homocitrate <=> cis-homoaconitate + H2O
REACT:R-SPO-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Schizosaccharomyces pombe)
REACT:R-DDI-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Dictyostelium discoideum)
RHEA:10942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + diphosphate => (2E)-geranyl diphosphate
GO:0120286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan sensor activity
GO:0120286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan sensing activity
RHEA:44922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH
RHEA:72356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + glutarate(in) => dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
RHEA:14681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-aminophenol + A + O2 = 2-aminophenoxazin-3-one + AH2 + 2 H2O
REACT:R-DRE-8937989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRC1 complexes (Danio rerio)
RHEA:34587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + pentalenolactone E = CO2 + pentalenolactone F + succinate
REACT:R-DRE-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Danio rerio)
REACT:R-HSA-9637699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CpnT hydrolyses NAD+ (Homo sapiens)
RHEA:15754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + IMP + L-aspartate => GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate
RHEA:44506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate => 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate
RHEA:66585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocholestane + A + H2O => 25-hydroxy 3-oxocholestane + AH2
REACT:R-CEL-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Caenorhabditis elegans)
REACT:R-SCE-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Saccharomyces cerevisiae)
RHEA:66588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in 26S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-8952058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)
REACT:R-DDI-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Dictyostelium discoideum)
REACT:R-HSA-9673288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds RAC1:GTP (Homo sapiens)
RHEA:49302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltose 6'-phosphate(in) + L-histidyl-[protein] => D-maltose(out) + N(pros)-phospho-L-histidyl-[protein]
RHEA:42011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-pregnan-20beta-ol-3-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH
REACT:R-RNO-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Rattus norvegicus)
REACT:R-MMU-9663492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL dissociates from GSTA1, FABP1 (Mus musculus)
REACT:R-CFA-159752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Canis familiaris)
REACT:R-DRE-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Danio rerio)
REACT:R-GGA-8937631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Gallus gallus)
REACT:R-CFA-3000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BORA binds SCF-beta-TrCp1/2 (Canis familiaris)
RHEA:54363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + H(+) <=> 3-methylbutanal + CO2
REACT:R-DDI-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Dictyostelium discoideum)
RHEA:14411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hypotaurine => cysteamine + O2
REACT:R-RNO-9660192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR agonists bind VDR (Rattus norvegicus)
RHEA:38433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O
REACT:R-CEL-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Caenorhabditis elegans)
RHEA:64046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine => (13Z)-docosenoyl-CoA + sphing-4-enine
REACT:R-GGA-1013013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of GABA B receptor with G protein beta-gamma subunits (Gallus gallus)
RHEA:36462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-proline + H2O <=> glycine + L-proline
RHEA:41220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)
REACT:R-SSC-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Sus scrofa)
GO:0033250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	penicillinase activity
REACT:R-BTA-9647643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds bacterial cardiolipin (Bos taurus)
REACT:R-DME-9607304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Drosophila melanogaster)
REACT:R-MMU-4570499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Mus musculus)
RHEA:57327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]
REACT:R-HSA-8950716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA binds JAK1 (Homo sapiens)
REACT:R-CEL-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Caenorhabditis elegans)
REACT:R-MMU-9758604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of IKBKG by TRAF6 (Mus musculus)
REACT:R-SSC-2046285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The keratan chain can be capped by N-acetylneuraminic acid (Sus scrofa)
REACT:R-GGA-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Gallus gallus)
REACT:R-BTA-9606894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DAPP1 (p-BAM32) binds PLCG2 (Bos taurus)
REACT:R-GGA-5653766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)
RHEA:25826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + O2 + spermine
REACT:R-HSA-5656070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFBPs bind FGFs (Homo sapiens)
REACT:R-DDI-8854759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D14 binds RAB11 and ULK1 (Dictyostelium discoideum)
REACT:R-DME-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Drosophila melanogaster)
RHEA:39682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA
REACT:R-SSC-114697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Sus scrofa)
REACT:R-DME-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)
REACT:R-GGA-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)
RHEA:65889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-hydroxy-L-kynurenine => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate
REACT:R-CEL-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Caenorhabditis elegans)
RHEA:28568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 AMP + enterobactin + 7 H(+) => 3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP
REACT:R-MMU-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Mus musculus)
RHEA:30472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => (1S,5S,6S)-alpha-bergamotene + diphosphate
EC:3.2.1.165	skos:prefLabel	"exo-1,4-beta-D-glucosaminidase"
EC:3.2.1.165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exo-1,4-beta-D-glucosaminidase"
EC:3.2.1.165	skos:altLabel	"GlcNase"
EC:3.2.1.165	skos:altLabel	"exochitosanase"
EC:3.2.1.165	skos:altLabel	"exo-beta-D-glucosaminidase"
GO:0043334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity
GO:0043334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
REACT:R-CFA-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Canis familiaris)
REACT:R-MMU-5649734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates NEIL1,NEIL2-generated single strand break (Mus musculus)
RHEA:40376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
REACT:R-DME-2130279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Drosophila melanogaster)
REACT:R-HSA-1008200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 binds the beta globin locus control region (Homo sapiens)
RHEA:10809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxypropylphosphonate + H2O2 => (1R,2S)-epoxypropylphosphonate + 2 H2O
GO:0043780	skos:prefLabel	"cobalt-precorrin-5B (C(1))-methyltransferase"
GO:0043780	skos:altLabel	"cobalt-precorrin-6A synthase"
GO:0043780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobalt-precorrin-5B (C(1))-methyltransferase"
GO:0043780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin-5B C1-methyltransferase activity
GO:0043780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin 5B C1-methyltransferase activity
GO:0043780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylulose phosphate 3-epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribulose-5-phosphate 3-epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoketopentose 3-epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pentose-5-phosphate 3-epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribulose phosphate-3-epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoketopentose epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-xylulose-5-phosphate 3-epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribulose-5-phosphate epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pentose phosphate epimerase (PPE)
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribulose 5-phosphate 3-epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribulose-5-P 3-epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythrose-4-phosphate isomerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-ribulose 5-phosphate epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose-phosphate 3-epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribulose epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribulose-phosphate 3-epimerase activity
GO:0004750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythrose-4-phosphate epimerase activity
REACT:R-DME-204779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang1 (Drosophila melanogaster)
REACT:R-CEL-418170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB1 binds MAPKs, SRC-1 (Caenorhabditis elegans)
REACT:R-HSA-194809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botD LC cleaves target cell VAMP1 (Homo sapiens)
REACT:R-CFA-110011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Grb10 to the insulin receptor (Canis familiaris)
REACT:R-SSC-8875320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 GEFs exchange GTP for GDP on RAB5 (Sus scrofa)
GO:0102605	skos:prefLabel	"cyclooctatin synthase"
GO:0102605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclooctatin synthase"
GO:0102605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cyclooctat-9-ene-5,7-diol + O2 = A + cyclooctatin + H2O
GO:0102605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclooctat-9-en-5,7-diol C18-monooxygenase activity
RHEA:13998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + CoA + NAD(+) => 2-methylpropanoyl-CoA + CO2 + NADH
RHEA:53739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-halobenzoate + H(+) + NADH + O2 <=> a halide anion + catechol + CO2 + NAD(+)
RHEA:22466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]
EC:1.1.1.41	skos:altLabel	"NAD-linked isocitrate dehydrogenase"
EC:1.1.1.41	skos:prefLabel	"isocitrate dehydrogenase (NAD(+))"
EC:1.1.1.41	skos:altLabel	"nicotinamide adenine dinucleotide isocitrate dehydrogenase"
EC:1.1.1.41	skos:altLabel	"isocitrate dehydrogenase (NAD)"
EC:1.1.1.41	skos:altLabel	"NAD-specific isocitrate dehydrogenase"
EC:1.1.1.41	skos:altLabel	"isocitric dehydrogenase"
EC:1.1.1.41	skos:altLabel	"NAD isocitrate dehydrogenase"
EC:1.1.1.41	skos:altLabel	"beta-ketoglutaric-isocitric carboxylase"
EC:1.1.1.41	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isocitrate dehydrogenase (NAD(+))"
EC:1.1.1.41	skos:altLabel	"NAD dependent isocitrate dehydrogenase"
EC:1.1.1.41	skos:altLabel	"IDH"
EC:1.1.1.41	skos:altLabel	"isocitric acid dehydrogenase"
EC:1.1.1.41	skos:altLabel	"NAD isocitric dehydrogenase"
RHEA:65491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP <=> 2',3',3'-c-tri-AMP + 3 diphosphate
REACT:R-MMU-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Mus musculus)
GO:0022875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity
GO:0022875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol PTS transporter activity
REACT:R-RNO-9718379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds chemical antagonists (Rattus norvegicus)
RHEA:23681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-diphosphate + H(+) + phosphate
RHEA:62500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-arginyl-AMP = AMP + H(+) + L-arginyl-[peptidyl-carrier protein]
GO:0033798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inner ring-deiodinating pathway
GO:0033798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iodothyronine 5-deiodinase activity
GO:0033798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyroxine 5-deiodinase activity
GO:0033798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity
GO:0033798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iodothyronine inner ring monodeiodinase activity
GO:0033798	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type III iodothyronine deiodinase activity
GO:0033798	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	diiodothyronine 5'-deiodinase activity
REACT:R-SSC-350319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of vimentin at IDVD (259) (Sus scrofa)
RHEA:28033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dGDP + H2O <=> [thioredoxin]-dithiol + GDP
REACT:R-PFA-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Plasmodium falciparum)
REACT:R-HSA-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Homo sapiens)
RHEA:38631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-DRE-183094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds CBL:Beta-Pix (Danio rerio)
REACT:R-SSC-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Sus scrofa)
REACT:R-DRE-9660192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR agonists bind VDR (Danio rerio)
RHEA:43472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate
RHEA:62756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CFA-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Canis familiaris)
REACT:R-MMU-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)
RHEA:11490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an all-trans-retinyl ester + CoA => all-trans-retinol + an acyl-CoA
REACT:R-BTA-5635102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 is internalized (Bos taurus)
RHEA:15047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+)
RHEA:61699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + holo-[peptidyl-carrier protein] <=> AMP + diphosphate + glycyl-[peptidyl-carrier protein]
RHEA:46196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-170087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Homo sapiens)
REACT:R-CFA-5691411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Canis familiaris)
REACT:R-DRE-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Danio rerio)
REACT:R-DRE-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Danio rerio)
RHEA:14303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxate + H(+) => 4-pyridoxolactone + H2O
REACT:R-BTA-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Bos taurus)
REACT:R-DME-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Drosophila melanogaster)
RHEA:66217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-C7-CoA + O2 => asc-DeltaC7-CoA + H2O2
REACT:R-BTA-8943007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Bos taurus)
RHEA:41509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + NADPH + O2 => H2O + N(5)-hydroxy-L-ornithine + NADP(+)
REACT:R-SSC-264615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Sus scrofa)
REACT:R-DME-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Drosophila melanogaster)
REACT:R-HSA-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)
RHEA:12730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutein => (3R,3'S)-zeaxanthin
REACT:R-SSC-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Sus scrofa)
RHEA:70140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Rattus norvegicus)
RHEA:16255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + phenanthrene-3,4-diol => (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+)
GO:0008374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acyltransferase activity
RHEA:41021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol
REACT:R-HSA-9757706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Homo sapiens)
RHEA:56769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-zeaxanthin + 2 O2 => 2 A + all-trans-adonixanthin + 3 H2O
RHEA:28666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + melibiose <=> D-galactose + D-glucose
REACT:R-CFA-8951850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Canis familiaris)
RHEA:40061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + decanoate + H(+) => decanoyl-CoA + H2O
REACT:R-SSC-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)
GO:0047557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aci-nitropropanoate oxidase activity
GO:0047557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-aci-nitropropanoate:oxygen oxidoreductase activity
GO:0047557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionate-3-nitronate oxidase activity
REACT:R-RNO-6803761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Rattus norvegicus)
REACT:R-BTA-163010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Down Regulation of Emi1 through Phosphorylation of Emi1 (Bos taurus)
REACT:R-SCE-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Saccharomyces cerevisiae)
RHEA:71563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminomethyl-dUMP in DNA + acetyl-CoA = 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)
RHEA:36845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA
GO:0008888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked glycerol dehydrogenase activity
GO:0008888	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycerol dehydrogenase activity
GO:0008888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol dehydrogenase [NAD+] activity
REACT:R-DRE-5693539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of DNA and formation of Holliday structures following repair synthesis (Danio rerio)
REACT:R-HSA-2514854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates condensin I (Homo sapiens)
REACT:R-RNO-936991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Rattus norvegicus)
REACT:R-MMU-202534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of NEMO by TRAF6 (Mus musculus)
REACT:R-DDI-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Dictyostelium discoideum)
REACT:R-HSA-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Homo sapiens)
REACT:R-HSA-374758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)
GO:0003823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	B cell receptor activity
GO:0003823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	immunoglobulin
GO:0003823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	opsonin activity
GO:0003823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	antibody
GO:0003823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	antigen binding
RHEA:53775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + lithocholoyl-CoA <=> chenodeoxycholoyl-CoA + lithocholate
REACT:R-MMU-5602080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Mus musculus)
GO:0099106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion channel regulator activity
REACT:R-HSA-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Homo sapiens)
RHEA:13840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) <=> 4,5-dihydroxyphthalate + H(+) + NADH
REACT:R-CFA-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Canis familiaris)
RHEA:42422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-4-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2
REACT:R-HSA-193641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKK-beta is recruited (Homo sapiens)
REACT:R-CFA-8981534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin dimer:KIRREL binds FYN (Canis familiaris)
REACT:R-GGA-8937767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 dephosphorylates RUNX1 (Gallus gallus)
RHEA:25709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-dihomomethionine <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O
RHEA:15271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-ascorbate => L-xylo-hex-3-ulonolactone
RHEA:28599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-lysine => acetate + L-lysine
RHEA:46212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine = 4-amino-5-aminomethyl-2-methylpyrimidine + formate
RHEA:27803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => all-trans-decaprenyl diphosphate + 7 diphosphate
EC:3.4.22.24	skos:prefLabel	"cathepsin T"
EC:3.4.22.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin T"
REACT:R-SSC-400183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA:RXRA binds Corepressors of PPARA (Sus scrofa)
RHEA:28864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + lactose(in) => H(+)(in) + lactose(out)
REACT:R-HSA-380233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)
REACT:R-HSA-9674529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds to TBXA2R (Homo sapiens)
REACT:R-CEL-9650165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers bind H+ (Caenorhabditis elegans)
RHEA:31675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"perakine reductase"
RHEA:31675	skos:prefLabel	"perakine reductase"
RHEA:31675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + raucaffrinoline = H(+) + NADPH + perakine
REACT:R-CFA-8851933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates GAB1 (Canis familiaris)
REACT:R-MMU-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Mus musculus)
RHEA:11358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + NAD(+) => A + H(+) + NADH
REACT:R-HSA-9662710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 gene produces IL6 protein (Homo sapiens)
RHEA:13717	skos:altLabel	"1-deoxyxylulose-5-phosphate reductoisomerase"
RHEA:13717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH
RHEA:13717	skos:prefLabel	"1-deoxy-D-xylulose-5-phosphate reductoisomerase"
RHEA:13717	skos:altLabel	"DXP-reductoisomerase"
RHEA:13717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-deoxy-D-xylulose-5-phosphate reductoisomerase"
RHEA:40200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide A + H(+) + phosphate
REACT:R-SPO-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Schizosaccharomyces pombe)
RHEA:11933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanenitrile => acetone + hydrogen cyanide
GO:0047637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity
GO:0047637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanyl phosphatidylglycerol synthetase activity
GO:0047637	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-alanylphosphatidylglycerol synthase activity
GO:0047637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanylphosphatidylglycerol synthase activity
GO:0044653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dextrin alpha-glucosidase activity
REACT:R-DME-177931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)
RHEA:71636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) + 2 thiosulfate(out) => phosphate(out) + 2 thiosulfate(in)
RHEA:58086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoate + glycerol + H(+) => 1-(13Z-docosenoyl)-glycerol + H2O
RHEA:18575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chelirubine + H2O2 => dihydrochelirubine + H(+) + O2
REACT:R-HSA-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Homo sapiens)
RHEA:16302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) => ADP-D-ribose + H(+) + nicotinamide
REACT:R-MMU-109291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Mus musculus)
GO:0047585	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-pyridoxolactone lactonohydrolase activity
GO:0047585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxolactonase activity
REACT:R-MMU-1236941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of receptor bound antigen into clathrin coted vesicles (Mus musculus)
RHEA:32882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R,5R)-5-hydroxycamphor + NAD(+) <=> (1R,4R)-bornane-2,5-dione + H(+) + NADH
REACT:R-HSA-3322125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MMAB does not transfer adenosyl group from ATP to B12s (Homo sapiens)
RHEA:10014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxypseudooxynicotine + H2O2 => (R)-6-hydroxynicotine + H2O + O2
REACT:R-SPO-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Schizosaccharomyces pombe)
REACT:R-DRE-4755524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1I2 with SUMO3 (Danio rerio)
REACT:R-HSA-70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer oxidises LACT to PYR (Homo sapiens)
RHEA:59645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylobiono-1,5-lactone + H2O => D-xylobionate + H(+)
GO:0050038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylulose reductase (NADP+) activity
GO:0050038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-xylulose reductase activity
RHEA:38797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
GO:0018816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutyrate dehydratase activity
REACT:R-DME-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Drosophila melanogaster)
RHEA:10243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-[ACP] + NAD(+) <=> a (2E)-enoyl-[ACP] + H(+) + NADH
RHEA:19479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + H2O + NADP(+) => 4-hydroxybenzoate + H(+) + NADPH + O2
REACT:R-HSA-5334052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFC7L2 mutants don't bind CTBP (Homo sapiens)
REACT:R-DDI-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)
RHEA:25899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonate <=> acetate + CO2
REACT:R-HSA-5615682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complexed PIWIL1 binds pre-piRNA (Homo sapiens)
REACT:R-MMU-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Mus musculus)
RHEA:34089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol
REACT:R-XTR-450620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S193-KSRP binds 14-3-3zeta in the nucleus (Xenopus tropicalis)
RHEA:29866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + GTP <=> ADP + GDP
RHEA:24172	skos:prefLabel	"3-oxo-5beta-steroid 4-dehydrogenase"
RHEA:24172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxo-5beta-steroid 4-dehydrogenase"
RHEA:24172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-5beta-steroid = a 3-oxo-Delta(4)-steroid + AH2
RHEA:24172	skos:altLabel	"Delta(4)-3-ketosteroid 5-beta-reductase"
REACT:R-XTR-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Xenopus tropicalis)
REACT:R-DRE-5696007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF3 ligates CoA-SH to VLCFA (Danio rerio)
REACT:R-HSA-1549564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPTN11 dephosphorylates SPRY2 (Homo sapiens)
REACT:R-PFA-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Plasmodium falciparum)
REACT:R-DRE-3769397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOST binds LRP5/6 (Danio rerio)
REACT:R-BTA-6805650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA2-NuRD complex deacetylates TP53 (Bos taurus)
REACT:R-HSA-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Homo sapiens)
RHEA:69577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+) => (R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2
REACT:R-MMU-5654165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR1 (Mus musculus)
RHEA:58771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)
REACT:R-GGA-8942607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Gallus gallus)
REACT:R-BTA-2130349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Generation of CLIP from lip10 (Bos taurus)
REACT:R-PFA-193064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3-like proteins reducde ANDST to TEST (Plasmodium falciparum)
RHEA:56642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:25478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[acetyl-CoA carboxylase] kinase activity
GO:0050405	skos:altLabel	"acetyl-coenzyme A carboxylase kinase"
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetyl-CoA carboxylase kinase 2 activity
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetyl-CoA carboxylase kinase-2 activity
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetyl-CoA carboxylase kinase-3 (AMP-activated) activity
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK5
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A carboxylase kinase (phosphorylating) activity
GO:0050405	skos:altLabel	"AMPK"
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMPK
GO:0050405	skos:altLabel	"acetyl-CoA carboxylase kinase"
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[acetyl-CoA carboxylase] kinase"
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACK3
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-coenzyme A carboxylase kinase activity
GO:0050405	skos:prefLabel	"[acetyl-CoA carboxylase] kinase"
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA carboxylase kinase (cAMP-independent) activity
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA carboxylase kinase (AMP-activated) activity
GO:0050405	skos:altLabel	"acetyl coenzyme A carboxylase kinase (phosphorylating)"
GO:0050405	skos:altLabel	"acetyl-CoA carboxylase kinase (cAMP-independent)"
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:acetyl-CoA carboxylase phosphotransferase activity
GO:0050405	skos:altLabel	"acetyl-CoA carboxylase bound kinase"
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	I-peptide kinase activity
GO:0050405	skos:altLabel	"acetyl-CoA carboxylase kinase (AMP-activated)"
GO:0050405	skos:altLabel	"I-peptide kinase"
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetyl-CoA carboxylase bound kinase activity
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA carboxylase kinase activity
GO:0050405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ACK2
REACT:R-BTA-4615873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates SUZ12 with SUMO1 (Bos taurus)
REACT:R-CEL-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Caenorhabditis elegans)
REACT:R-SPO-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Schizosaccharomyces pombe)
REACT:R-DDI-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Dictyostelium discoideum)
REACT:R-GGA-450434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Gallus gallus)
REACT:R-SPO-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)
REACT:R-DRE-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)
REACT:R-RNO-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Rattus norvegicus)
REACT:R-SPO-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)
RHEA:26332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + L-lysine <=> (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate
REACT:R-SCE-157849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes containing mRNA that does not circularize (Saccharomyces cerevisiae)
RHEA:37556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-kanosamine 6-phosphate + H2O => kanosamine + phosphate
REACT:R-MMU-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Mus musculus)
REACT:R-GGA-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Gallus gallus)
RHEA:56068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP
RHEA:19994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (S)-S-oxide
RHEA:15455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sarcosine
REACT:R-CFA-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
RHEA:52877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-HSA-6782419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp) (Homo sapiens)
REACT:R-XTR-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Xenopus tropicalis)
RHEA:46724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methyltetradecanoyl-CoA = (2R)-2-methyltetradecanoyl-CoA
REACT:R-BTA-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Bos taurus)
REACT:R-SPO-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Schizosaccharomyces pombe)
REACT:R-DME-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
RHEA:63513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2'-diol + H(+) + NADH + O2 => biphenyl-2,2',3-triol + H2O + NAD(+)
REACT:R-CFA-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Canis familiaris)
REACT:R-XTR-211929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C19 5-hydroxylates omeprazole (Xenopus tropicalis)
REACT:R-HSA-3341397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
RHEA:15759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-aspartate 4-semialdehyde + NADH => L-homoserine + NAD(+)
RHEA:24363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + siroheme <=> Fe(2+) + sirohydrochlorin
REACT:R-DDI-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Dictyostelium discoideum)
RHEA:71787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + O2 = (R)-2-hydroxyglutarate + CO2
REACT:R-XTR-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Xenopus tropicalis)
RHEA:64135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine
RHEA:69464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine = 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-SSC-186798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binds to PDGF-beta receptors only (Sus scrofa)
GO:0070006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloaminopeptidase activity
REACT:R-BTA-5674130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
RHEA:57267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP <=> GDP + glycolate + H(+)
REACT:R-SSC-1676149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Sus scrofa)
RHEA:14625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dextrin dextranase"
RHEA:14625	skos:altLabel	"dextrin 6-glucosyltransferase"
RHEA:14625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) = [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)
RHEA:14625	skos:prefLabel	"dextrin dextranase"
REACT:R-DDI-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Dictyostelium discoideum)
RHEA:57603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-2168079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL (GWL) phosphorylates ARPP19 (Homo sapiens)
REACT:R-HSA-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Homo sapiens)
REACT:R-MMU-83790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Mus musculus)
REACT:R-XTR-351913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of TJP1 (Xenopus tropicalis)
REACT:R-GGA-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Gallus gallus)
REACT:R-CFA-9010815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLITs bind keratan sulfate (Canis familiaris)
REACT:R-RNO-8873929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates STARD10 (Rattus norvegicus)
RHEA:39936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
RHEA:24392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate
RHEA:24392	skos:prefLabel	"dTDP-dihydrostreptose--streptidine-6-phosphate dihydrostreptosyltransferase"
RHEA:24392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-dihydrostreptose--streptidine-6-phosphate dihydrostreptosyltransferase"
RHEA:59385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-amino-L-phenylalanine => 3-(4-aminophenyl)pyruvate + L-glutamate
REACT:R-SSC-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Sus scrofa)
RHEA:56082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+) => [Rab1 protein]-L-serine + CDP-choline
REACT:R-RNO-6798373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates DYRK2 (Rattus norvegicus)
REACT:R-SPO-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)
GO:0060698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoribonuclease inhibitor activity
GO:0120242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminobutanoate deaminase activity
GO:0120242	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-iminobutanoate/2-iminopropanoate deaminase
RHEA:11902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + CO2 + NADH => (2R,3S)-homoisocitrate + NAD(+)
REACT:R-RNO-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Rattus norvegicus)
GO:0102261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity
RHEA:43937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-ene-3,17-dione => androst-4-ene-3,17-dione
RHEA:58094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O
RHEA:13828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH
REACT:R-SSC-350318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at TNLD (429) (Sus scrofa)
REACT:R-SCE-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Saccharomyces cerevisiae)
RHEA:27941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-D-aspartate <=> glycine + glyoxylate
RHEA:59133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP => AMP + diphosphate + H(+) + staphyloferrin B
REACT:R-SSC-5617037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Sus scrofa)
REACT:R-SSC-1236941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of receptor bound antigen into clathrin coted vesicles (Sus scrofa)
REACT:R-SSC-203680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:NOSIP translocation from caveolae to intracellular compartments (Sus scrofa)
REACT:R-CFA-352182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Canis familiaris)
REACT:R-MMU-9661432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds ALB (Mus musculus)
RHEA:16555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => aldehydo-D-ribose 5-phosphate + L-lysyl-[protein]
REACT:R-RNO-205306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP1 and KIT (Rattus norvegicus)
REACT:R-MMU-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)
RHEA:47694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B => AH2 + neomycin C + S-adenosyl-L-methionine
REACT:R-HSA-936991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Homo sapiens)
REACT:R-DDI-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Dictyostelium discoideum)
REACT:R-SSC-8855111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds PCSK9 (Sus scrofa)
REACT:R-CEL-8863494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASICs bind STOML3, (STOM) (Caenorhabditis elegans)
GO:0018759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity
GO:0018759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)
GO:0018759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methenyl-H4MPT cyclohydrolase activity
GO:0018759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methenyltetrahydromethanopterin cyclohydrolase activity
GO:0018759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methenyltetrahydromethanopterin cyclohydrolase activity
GO:0018759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methenyl-H(4)MPT cyclohydrolase activity
RHEA:35496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-aminobenzoyl)-L-glutamate => 4-aminobenzoate + L-glutamate
RHEA:47744	skos:prefLabel	"demethylphylloquinone reductase"
RHEA:47744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethylphylloquinone reductase"
RHEA:47744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylphylloquinone + H(+) + NADPH = demethylphylloquinol + NADP(+)
RHEA:23671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]
REACT:R-XTR-8875451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates CBL (Xenopus tropicalis)
REACT:R-CEL-183067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Localization of CBL:GRB2 to the membrane (Caenorhabditis elegans)
GO:0016287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxyacetone phosphate acyltransferase activity
GO:0016287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:glycerone-phosphate O-acyltransferase activity
GO:0016287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerone-phosphate O-acyltransferase activity
GO:0047518	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-methyladenosine ribohydrolase activity
GO:0047518	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-methyladenosine hydrolase activity
GO:0047518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methyladenosine nucleosidase activity
RHEA:63479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADPH
GO:0018580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitronate monooxygenase activity
GO:0018580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitronate:oxygen 2-oxidoreductase (nitrite-forming) activity
GO:0018580	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-nitropropane dioxygenase activity
REACT:R-PFA-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Plasmodium falciparum)
REACT:R-RNO-380316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of NuMA with microtubules (Rattus norvegicus)
REACT:R-SPO-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Schizosaccharomyces pombe)
REACT:R-HSA-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Homo sapiens)
RHEA:62844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)
RHEA:62072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose 6-phosphate + NADP(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH
RHEA:60726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + 2 H(+) + NADPH => dodecanal + H2O + NADP(+)
REACT:R-DDI-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Dictyostelium discoideum)
EC:2.4.1.109	skos:prefLabel	"dolichyl-phosphate-mannose--protein mannosyltransferase"
EC:2.4.1.109	skos:altLabel	"dolichol phosphomannose-protein mannosyltransferase"
EC:2.4.1.109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-phosphate-mannose--protein mannosyltransferase"
EC:2.4.1.109	skos:altLabel	"dolichyl-phosphate-mannose-protein mannosyltransferase"
REACT:R-HSA-5684868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPC translocates from ER membrane to multivesicle body (Homo sapiens)
EC:3.4.23.17	skos:altLabel	"prohormone converting enzyme"
EC:3.4.23.17	skos:prefLabel	"pro-opiomelanocortin converting enzyme"
EC:3.4.23.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pro-opiomelanocortin converting enzyme"
REACT:R-DME-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Drosophila melanogaster)
REACT:R-GGA-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Gallus gallus)
REACT:R-BTA-9638090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Bos taurus)
REACT:R-RNO-1474210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP14 (Rattus norvegicus)
REACT:R-CFA-6784598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPPA(124-151) binds NPR1 (Canis familiaris)
RHEA:68580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-kynurenine(out) = ADP + H(+) + L-kynurenine(in) + phosphate
REACT:R-XTR-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)
RHEA:31605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-aminoacrylate + carbamate + H(+) => (Z)-3-ureidoacrylate + H2O
REACT:R-SSC-199404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40L binds CD40 (Sus scrofa)
RHEA:49218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O
REACT:R-MMU-2424486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)
RHEA:65309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]
REACT:R-BTA-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Bos taurus)
REACT:R-BTA-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Bos taurus)
REACT:R-XTR-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Xenopus tropicalis)
RHEA:23683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-diphosphate + H(+) + phosphate
REACT:R-HSA-9008822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1D dephosphorylates RUNX2 (Homo sapiens)
RHEA:55174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexanoyl-CoA + O2
REACT:R-GGA-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)
RHEA:68362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydro-L-arabinono-1,4-lactone + H(+) + H2O2 => L-xylono-1,4-lactone + O2
REACT:R-MMU-1299359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TALK (Mus musculus)
RHEA:51576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phlorizin synthase"
RHEA:51576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phloretin + UDP-alpha-D-glucose = H(+) + phlorizin + UDP
RHEA:51576	skos:prefLabel	"phlorizin synthase"
RHEA:65746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + decanal + H(+) + succinate + sulfate => 2-oxoglutarate + decyl sulfate + O2
GO:0008710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-KAP synthetase activity
GO:0008710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-keto-8-aminopelargonic acid synthetase activity
GO:0008710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-keto-8-amino-pelargonic acid synthetase activity
GO:0008710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)
GO:0008710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-keto-8-aminopelargonic synthetase activity
GO:0008710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-amino-7-oxononanoate synthase activity
GO:0008710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	8-amino-7-oxopelargonate synthase activity
GO:0008710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	8-amino-7-ketopelargonate synthase activity
GO:0008710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AONS activity
REACT:R-SSC-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)
REACT:R-CEL-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Caenorhabditis elegans)
REACT:R-CEL-450499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B (AKT) phosphorylates KSRP (Caenorhabditis elegans)
REACT:R-GGA-8943959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP9 cleave SCUBE3 (Gallus gallus)
REACT:R-CEL-432110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Caenorhabditis elegans)
REACT:R-DDI-5216234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Dictyostelium discoideum)
REACT:R-RNO-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Rattus norvegicus)
RHEA:59963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha)-acetyl-D-methionine <=> N(alpha)-acetyl-L-methionine
RHEA:26497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + L-tryptophan + O2 <=> 7-chloro-L-tryptophan + FAD + 2 H2O
REACT:R-RNO-2395223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyridinoline cross-links (Rattus norvegicus)
REACT:R-SSC-211193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization  of DFF40 (Sus scrofa)
REACT:R-SCE-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)
REACT:R-DDI-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Dictyostelium discoideum)
REACT:R-HSA-193491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Homo sapiens)
RHEA:42608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
RHEA:67189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) => ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate
REACT:R-DRE-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Danio rerio)
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoprotein 7(9)-O-acetyltransferase activity
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate O7-(or O9-)acetyltransferase activity
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate 7(8)-O-acetyltransferase activity
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sialate O-acetyltransferase
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate 7,8-O-acetyltransferase activity
GO:0047186	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity
RHEA:64808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + O-(2-aminoethyl)-L-serine = CoA + H(+) + O-(2-acetamidoethyl)-L-serine
REACT:R-DME-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Drosophila melanogaster)
RHEA:15790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylose + NADP(+) => H(+) + L-xylono-1,4-lactone + NADPH
REACT:R-CFA-977317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Canis familiaris)
RHEA:17993	skos:altLabel	"beta-alanine specific hGSH synthetase"
RHEA:17993	skos:altLabel	"homoglutathione synthetase"
RHEA:17993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + gamma-L-glutamyl-L-cysteine = ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate
RHEA:17993	skos:prefLabel	"homoglutathione synthase"
RHEA:17993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homoglutathione synthase"
REACT:R-BTA-5368580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Bos taurus)
RHEA:71631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) + sulfate(out) = phosphate(out) + sulfate(in)
GO:0102466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-carotene 2,2'-beta-hydroxylase activity
REACT:R-SCE-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Saccharomyces cerevisiae)
REACT:R-HSA-167468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive HIV-1 Initiation After Second Transition (Homo sapiens)
RHEA:70182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-maltotetraose <=> alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose
REACT:R-RNO-1250264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP binds reduced thioredoxin (Rattus norvegicus)
RHEA:14418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + L-lysine => H(+) + N(6)-acetyl-L-lysine + phosphate
REACT:R-GGA-5226964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKH transports PPi from cytosol to extracellular region (Gallus gallus)
RHEA:11829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O => a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)
REACT:R-MMU-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Mus musculus)
RHEA:44967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H(+) + NADPH <=> dodecanoyl-CoA + NADP(+)
RHEA:32888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + O2 => 2 all-trans-retinal
REACT:R-DME-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Drosophila melanogaster)
RHEA:19633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-erythro-3,5-diaminohexanoate dehydrogenase"
RHEA:19633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) = (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)
RHEA:19633	skos:prefLabel	"L-erythro-3,5-diaminohexanoate dehydrogenase"
RHEA:32240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-carotene => all-trans-beta-carotene
RHEA:21528	skos:altLabel	"metaphosphatase"
RHEA:21528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exopolyphosphatase"
RHEA:21528	skos:altLabel	"exopolypase"
RHEA:21528	skos:prefLabel	"exopolyphosphatase"
RHEA:21528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate
REACT:R-CFA-190682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin synthesis (generic) (Canis familiaris)
RHEA:53656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 = (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate
GO:0000156	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	two-component response regulator activity
GO:0000156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorelay response regulator activity
REACT:R-CFA-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Canis familiaris)
REACT:R-RNO-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Rattus norvegicus)
REACT:R-CEL-8867754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)
REACT:R-SSC-5229194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Depolymerization of lamin filaments after PKC-mediated phosphorylation (Sus scrofa)
RHEA:25549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate => abieta-8(14),12-diene + diphosphate
RHEA:58712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + O2 + rifampicin = H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide
RHEA:47658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-L-methionine sulfone => acetyl-CoA + L-methionine sulfone
REACT:R-MMU-2028644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Mus musculus)
REACT:R-HSA-9010645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP5 recruits PPP3CB (PP2BB) to ROBO2 (Homo sapiens)
REACT:R-GGA-8851018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A1 binds DC-SIGN (Gallus gallus)
RHEA:61371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferone sulfate(in) + ATP + H2O <=> 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate
REACT:R-XTR-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Xenopus tropicalis)
RHEA:61444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)
REACT:R-RNO-6811411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the Golgi (Rattus norvegicus)
GO:0140809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4-R3 arginine deiminase activity
GO:0140809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H4-R3 citrullination
GO:0140809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4R3 arginine deiminase activity
GO:0140809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine deiminase activity (H4-R3 specific)
REACT:R-HSA-9768939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds NPAS4 gene enhancer elements (Homo sapiens)
REACT:R-HSA-750988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (z) reassociates with G beta:gamma (Homo sapiens)
REACT:R-SPO-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Schizosaccharomyces pombe)
REACT:R-MMU-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Mus musculus)
REACT:R-DRE-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Danio rerio)
REACT:R-CFA-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Canis familiaris)
GO:0015056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotrophin-releasing factor receptor activity
REACT:R-HSA-9749098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 binds to DNA at origin of replication sites (Homo sapiens)
REACT:R-DRE-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Danio rerio)
REACT:R-HSA-8853252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2:C3d,C3dg,iC3b binds CD19:CD81 (Homo sapiens)
REACT:R-MMU-751027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Mus musculus)
REACT:R-CFA-1247668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A binds O2, releasing H+ and CO2 (Canis familiaris)
REACT:R-BTA-418576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 1:Gq complex (Bos taurus)
REACT:R-HSA-9613476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)
REACT:R-BTA-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Bos taurus)
REACT:R-GGA-168848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAK protein (Gallus gallus)
REACT:R-CEL-8852552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1R autophosphorylates (Caenorhabditis elegans)
RHEA:16867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA => choloyl-CoA + propanoyl-CoA
GO:0043806	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	keto-acid formate acetyltransferase
GO:0043806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-acid formate lyase activity
GO:0043806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto acid formate lyase activity
GO:0043806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-acid formate-lyase activity
RHEA:58850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeranial + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)
REACT:R-CFA-8852010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL2 binds activated T cells surface (Canis familiaris)
REACT:R-BTA-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Bos taurus)
RHEA:41330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2
RHEA:49882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-5218804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK activation by VEGFR (Mus musculus)
RHEA:22348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminoimidazole + H(+) + H2O = imidazol-4-one + NH4(+)
RHEA:22348	skos:prefLabel	"aminoimidazolase"
RHEA:22348	skos:altLabel	"4-aminoimidazole deaminase"
RHEA:22348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminoimidazolase"
REACT:R-BTA-8863973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of ERC and phagosome (Bos taurus)
REACT:R-DME-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-BTA-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Bos taurus)
REACT:R-SSC-5362553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTUM releases Hh-Np:GPC5 from the plasma membrane (Sus scrofa)
RHEA:57421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 oxidized [cytochrome P450] => H(+) + NAD(+) + 2 reduced [cytochrome P450]
REACT:R-XTR-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
GO:0031727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monocyte chemoattractant protein 1 receptor binding
GO:0031727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR2 chemokine receptor binding
GO:0031727	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR2 chemokine receptor ligand
REACT:R-BTA-429581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 transports vitamins from extracellular region to cytosol (Bos taurus)
RHEA:68011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate
RHEA:46601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[HPr protein]-L-serine + ATP => [HPr protein]-O-phospho-L-serine + ADP + H(+)
RHEA:17368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mn(2+)(out) <=> ADP + H(+) + Mn(2+)(in) + phosphate
RHEA:41508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine + NADP(+)
REACT:R-BTA-8857928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIHBP1 binds HSPG:LPL dimer (Bos taurus)
REACT:R-HSA-1855180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Homo sapiens)
REACT:R-BTA-4084980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Bos taurus)
REACT:R-CFA-9706312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to LCK (Canis familiaris)
GO:0047807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:zeatin 7-glucosyltransferase activity
GO:0047807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokinin 7-b-glucosyltransferase activity
GO:0047807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokinin 7-beta-glucosyltransferase activity
GO:0047807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:zeatin 7-glucosyltransferase activity
GO:0047807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-zeatin 7-glucosyltransferase activity
GO:0047807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytokinin 7-glucosyltransferase activity
GO:0047807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-zeatin 7-glucosyltransferase activity
REACT:R-HSA-9014467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the ER membrane (Homo sapiens)
REACT:R-RNO-2509816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses IDP to IMP (Rattus norvegicus)
EC:3.5.1.127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"jasmonoyl-L-amino acid hydrolase"
EC:3.5.1.127	skos:prefLabel	"jasmonoyl-L-amino acid hydrolase"
RHEA:46466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:44253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-448702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-1 active tetramer formation (Canis familiaris)
RHEA:66887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)
RHEA:67257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + propanal => 2 H(+) + NADH + propanoate
REACT:R-CEL-4332363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation and activation of CAMK2 (Caenorhabditis elegans)
RHEA:13192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O <=> 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)
REACT:R-BTA-391377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone receptor can bind LH (Bos taurus)
REACT:R-DRE-419843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCR (Danio rerio)
RHEA:44366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone 7-phosphate + ADP + H(+) => 2-epi-5-epi-valiolone + ATP
REACT:R-MMU-9009526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Mus musculus)
RHEA:64247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + glycine <=> an N-(fatty acyl)-glycine + CoA + H(+)
RHEA:48337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)
REACT:R-DRE-6806831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5Rs reduce MetHb to HbA (Danio rerio)
REACT:R-SSC-201637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plectin-1 (Sus scrofa)
RHEA:68696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
RHEA:43669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hexacosanoyl-CoA + hydrogencarbonate => 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate
REACT:R-HSA-1307802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds (Homo sapiens)
REACT:R-RNO-5205682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin promotes the ubiquitination of mitochondrial substrates (Rattus norvegicus)
REACT:R-RNO-9706328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SOCS2 (Rattus norvegicus)
RHEA:55705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hydrogen sulfide + NAD(+) => ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide
REACT:R-XTR-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Xenopus tropicalis)
REACT:R-MMU-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Mus musculus)
RHEA:33273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O
REACT:R-DME-8864343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCTD1 binds TFAP2 homo- and heterodimers (Drosophila melanogaster)
RHEA:57764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dinitrotoluene + NADH + O2 = 3-methyl-4-nitrocatechol + NAD(+) + nitrite
RHEA:70476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + sphing-4-enine => 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine
REACT:R-RNO-4754187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Rattus norvegicus)
REACT:R-RNO-352182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Rattus norvegicus)
REACT:R-DDI-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Dictyostelium discoideum)
REACT:R-DRE-5624492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK phosphorylates p21 RAF1 on S338 (Danio rerio)
GO:0071916	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dipeptide transporter activity
GO:0071916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dipeptide transmembrane transporter activity
RHEA:20948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfopyruvate + H(+) = CO2 + sulfoacetaldehyde
RHEA:20948	skos:prefLabel	"sulfopyruvate decarboxylase"
RHEA:20948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfopyruvate decarboxylase"
RHEA:20948	skos:altLabel	"sulfopyruvate carboxy-lyase"
REACT:R-CFA-170672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Canis familiaris)
RHEA:40069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O
RHEA:63810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + N(8)-citryl-spermidine => ATP + citrate + spermidine
REACT:R-SSC-5625774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Sus scrofa)
REACT:R-RNO-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Rattus norvegicus)
REACT:R-DME-9008822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1D dephosphorylates RUNX2 (Drosophila melanogaster)
RHEA:19191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate
REACT:R-CFA-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Canis familiaris)
REACT:R-XTR-9634850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT (Xenopus tropicalis)
REACT:R-RNO-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Rattus norvegicus)
RHEA:23473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 alpha,alpha'-trehalose 6-mycolate => alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose
REACT:R-RNO-8937631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Rattus norvegicus)
REACT:R-XTR-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Xenopus tropicalis)
RHEA:55707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hydrogen sulfide + NAD(+) <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide
RHEA:15983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-adenosyl-L-methionine
REACT:R-SCE-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Saccharomyces cerevisiae)
REACT:R-BTA-3465448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at DISC (Bos taurus)
REACT:R-BTA-76416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Benzene is hydroxylated to phenol (Bos taurus)
REACT:R-BTA-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Bos taurus)
RHEA:34875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH
REACT:R-CFA-427514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC deacetylates histone H3 (Canis familiaris)
GO:0090613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + H(+) + H2O = 5'-deoxyinosine + NH4(+)
GO:0090613	skos:prefLabel	"5'-deoxyadenosine deaminase"
GO:0090613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5'-deoxyadenosine deaminase"
GO:0090613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine deaminase activity
REACT:R-DME-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)
REACT:R-GGA-8986995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Gallus gallus)
REACT:R-DDI-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Dictyostelium discoideum)
REACT:R-DME-69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk1 (Drosophila melanogaster)
REACT:R-DDI-156526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)
RHEA:47733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-983424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of COPII coated vesicle (Homo sapiens)
REACT:R-DDI-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)
RHEA:19282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen
REACT:R-CEL-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Caenorhabditis elegans)
REACT:R-HSA-9664271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of PLCG from FCGR3A (Homo sapiens)
REACT:R-RNO-76472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ethylene is oxidized to Ethylene oxide by CYP1A1 (Rattus norvegicus)
RHEA:64305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenylpropylamine + pyruvate => 1-phenylpropan-1-one + L-alanine
RHEA:67258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + propanoate => H2O + NAD(+) + propanal
REACT:R-HSA-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Homo sapiens)
REACT:R-DME-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Drosophila melanogaster)
REACT:R-RNO-1474158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCHFR binds to GCH1 and negatively regulates its activity (Rattus norvegicus)
REACT:R-MMU-139970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO3:FAD N-oxidises TMA to TMAO (Mus musculus)
RHEA:60707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine
RHEA:26268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroabietadienal + H2O + NADP(+) <=> dehydroabietate + 2 H(+) + NADPH
EC:5.5.1.18	skos:prefLabel	"lycopene epsilon-cyclase"
EC:5.5.1.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lycopene epsilon-cyclase"
REACT:R-RNO-73798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AICAR + 10-Formyl-THF => FAICAR + THF (Rattus norvegicus)
RHEA:65908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + pyruvate = H2O + L-alanine + xanthurenate
REACT:R-HSA-5250606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botD LC cleaves target cell VAMP2 (Homo sapiens)
REACT:R-SSC-141351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAOX:FAD oxidises NASPN to SPM (Sus scrofa)
RHEA:39297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2
REACT:R-SSC-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Sus scrofa)
REACT:R-DME-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Drosophila melanogaster)
RHEA:46387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:41478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + zymosterol ester => an acyl-CoA + zymosterol
REACT:R-HSA-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Homo sapiens)
GO:0031748	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D1 dopamine receptor ligand
GO:0031748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D1A dopamine receptor binding
GO:0031748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D1 dopamine receptor binding
RHEA:38026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocotrienol <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol
REACT:R-CFA-382052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)
RHEA:50013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + tert-butanol => 2-methylpropane-1,2-diol + H2O + NADP(+)
RHEA:10793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2
REACT:R-GGA-158784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Gallus gallus)
REACT:R-SSC-6811472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IER3 recruits MAPKs to PP2A-B56-beta,gamma (Sus scrofa)
REACT:R-DME-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Drosophila melanogaster)
RHEA:56256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP
RHEA:51728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate
GO:0050148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:nucleoside-5'-phosphate diphosphotransferase activity
GO:0050148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 5'-phosphate + ATP = a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)
GO:0050148	skos:altLabel	"nucleotide pyrophosphokinase"
GO:0050148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleotide diphosphokinase"
GO:0050148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide pyrophosphokinase activity
GO:0050148	skos:prefLabel	"nucleotide diphosphokinase"
GO:0050148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide diphosphokinase activity
GO:0050148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleotide 3'-pyrophosphokinase activity
GO:0050148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP nucleotide 3'-pyrophosphokinase activity
GO:0050148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:nucleotide pyrophosphotransferase activity
REACT:R-SCE-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Saccharomyces cerevisiae)
REACT:R-SPO-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Schizosaccharomyces pombe)
GO:0010292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:GDP antiporter activity
REACT:R-CFA-450620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S193-KSRP binds 14-3-3zeta in the nucleus (Canis familiaris)
RHEA:25531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
REACT:R-DRE-9717206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Danio rerio)
REACT:R-BTA-6788855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3KRP phosphorylates PsiAm, RibAm (Bos taurus)
REACT:R-BTA-139899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of BAD protein by 14-3-3 (Bos taurus)
REACT:R-DDI-5653974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator binds Rag dimers (Dictyostelium discoideum)
RHEA:36340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine
RHEA:27723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP
REACT:R-BTA-69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Bos taurus)
GO:0102448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnetin 4'-O-methyltransferase activity
RHEA:29129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H2O + nitrite => a menaquinol + nitrate
RHEA:56151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sn-glycerol 3-phosphocholine <=> CoA + hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Xenopus tropicalis)
REACT:R-DRE-9632868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1B is phosphorylated in response to estrogen (Danio rerio)
REACT:R-RNO-9638046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY3:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)
GO:0018687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl 2,3-dioxygenase activity
GO:0018687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biphenyl 2,3-dioxygenase"
GO:0018687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl + H(+) + NADH + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)
GO:0018687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biphenyl dioxygenase activity
GO:0018687	skos:prefLabel	"biphenyl 2,3-dioxygenase"
GO:0018687	skos:altLabel	"biphenyl dioxygenase"
GO:0018687	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)
REACT:R-DDI-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Dictyostelium discoideum)
RHEA:60797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 => 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate
RHEA:64851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hex-3-en-1-ol + benzoyl-CoA <=> (3Z)-hex-3-en-1-yl benzoate + CoA
RHEA:30173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => hexadecanoyl-[ACP] + sn-glycerol 3-phosphate
REACT:R-RNO-158164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Rattus norvegicus)
REACT:R-HSA-389463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteinase-activated receptors can bind thrombin (Homo sapiens)
REACT:R-HSA-2046099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA (Homo sapiens)
REACT:R-HSA-156907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aminoacyl-tRNA  binds to the ribosome at the A-site (Homo sapiens)
REACT:R-XTR-5687360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLL or POLM extends aligned DNA DSB ends to fill gaps (Xenopus tropicalis)
REACT:R-GGA-5362525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1,C1 4-hydroxylate atRA (Gallus gallus)
RHEA:39078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenedioyl-CoA + H2O <=> (3S)-hydroxydodecanedioyl-CoA
REACT:R-DRE-3296309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR3 binds HCAR3 ligands (Danio rerio)
REACT:R-GGA-5662613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 exchanges zinc for copper (Gallus gallus)
EC:1.2.3.15	skos:prefLabel	"(methyl)glyoxal oxidase"
EC:1.2.3.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(methyl)glyoxal oxidase"
RHEA:67969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + presqualene diphosphate => H(+) + phosphate + presqualene monophosphate
REACT:R-CEL-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Caenorhabditis elegans)
RHEA:62778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2
REACT:R-DME-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Drosophila melanogaster)
REACT:R-MMU-9018868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Mus musculus)
RHEA:40544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-5654692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
REACT:R-HSA-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Homo sapiens)
REACT:R-BTA-2559439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD14:LPS binds CR3 (Bos taurus)
REACT:R-CEL-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Caenorhabditis elegans)
REACT:R-MMU-934559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is phosphorylated by phosphorylated MNK1 (Mus musculus)
RHEA:45258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate(in) => hexadecanoate(out)
REACT:R-BTA-420977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca permeable AMPA receptor ligand binding (Bos taurus)
RHEA:42934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA + S-adenosyl-L-methionine
REACT:R-SPO-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Schizosaccharomyces pombe)
REACT:R-CFA-5654633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS bind to PPTN11 (Canis familiaris)
RHEA:22830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+) => 1-(5-phospho-beta-D-ribosyl)-ATP + H2O
RHEA:52241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 Mn(2+) + O2 => 4 H(+) + 2 MnO2
GO:0005524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)
GO:0005524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding
REACT:R-HSA-6803388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates CDKN1A (p21) transcription (Homo sapiens)
RHEA:71161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-serine(in) + Na(+)(in) => H(+)(in) + L-serine(out) + Na(+)(out)
REACT:R-GGA-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Gallus gallus)
REACT:R-HSA-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Homo sapiens)
GO:0102570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine:phenylpyruvate aminotransferase activity
REACT:R-DDI-708349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD2 oligomerizes (Dictyostelium discoideum)
RHEA:46956	skos:altLabel	"caffeoyl-CoA reductase-Etf complex"
RHEA:46956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caffeoyl-CoA reductase"
RHEA:46956	skos:prefLabel	"caffeoyl-CoA reductase"
RHEA:46956	skos:altLabel	"electron-bifurcating caffeoyl-CoA reductase"
RHEA:46956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-5654705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
REACT:R-HSA-2130641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TGN-lysosome vesicle to lysosome (Homo sapiens)
REACT:R-HSA-2396395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) binds alpha-dystroglycan (Homo sapiens)
RHEA:17336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + zeatin <=> acetate + H(+) + L-lupinate
REACT:R-XTR-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Xenopus tropicalis)
RHEA:10980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine = D-serine
RHEA:10980	skos:prefLabel	"serine racemase"
RHEA:10980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine racemase"
REACT:R-PFA-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Plasmodium falciparum)
RHEA:27947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + H2O + O2 => 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)
REACT:R-DDI-141423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the MCC complex to the APC/C complex (Dictyostelium discoideum)
REACT:R-HSA-417858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y14 receptor can bind to UDP-glucose (Homo sapiens)
REACT:R-CFA-1482695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Canis familiaris)
RHEA:38445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a wax ester + CoA => a fatty acyl-CoA + a long chain fatty alcohol
RHEA:10879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + H(+) <=> CO2 + phenol
REACT:R-BTA-9018907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Bos taurus)
RHEA:41818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD2 (d18:1(4E)) + H(+) + UDP => ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-PFA-1369052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid influx (Plasmodium falciparum)
REACT:R-CFA-8934465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds PTPN12 (Canis familiaris)
REACT:R-GGA-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)
REACT:R-DRE-8932355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades Ub-NFE2L2 (Danio rerio)
RHEA:32134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2
REACT:R-HSA-9035167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the EEPD1 gene (Homo sapiens)
REACT:R-XTR-996727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REST recruits the BHC complex (Xenopus tropicalis)
RHEA:31398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + FAD + H(+) <=> all-trans-4,4'-diapophytofluene + FADH2
RHEA:60734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + perillate => H2O + NADP(+) + perillyl aldehyde
RHEA:45460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine
RHEA:70339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose
REACT:R-BTA-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Bos taurus)
GO:0015254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol channel activity
RHEA:44129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9E)-octadecenoate
REACT:R-XTR-2046180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSPG is secreted from the cell (Xenopus tropicalis)
RHEA:11965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol
RHEA:69833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => campestanol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Danio rerio)
RHEA:27605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate <=> di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate
RHEA:17121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine carbamoyltransferase"
RHEA:17121	skos:altLabel	"lysine transcarbamylase"
RHEA:17121	skos:prefLabel	"lysine carbamoyltransferase"
RHEA:17121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + L-lysine = H(+) + L-homocitrulline + phosphate
REACT:R-HSA-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
RHEA:19791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH => 4-(dimethylamino)azobenzene + H2O + NADP(+)
REACT:R-DRE-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
REACT:R-MMU-73931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Mus musculus)
GO:1901363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heterocyclic compound binding
REACT:R-BTA-6811472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IER3 recruits MAPKs to PP2A-B56-beta,gamma (Bos taurus)
RHEA:53352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20b) in tRNA + NAD(+) = H(+) + NADH + uridine(20b) in tRNA
REACT:R-DRE-5607720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p100:RELB binds active NIK:p-IKKA dimer (Danio rerio)
GO:0051267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CP2 ethanolamine phosphate transferase activity
GO:0051267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gpi7 activity
GO:0051267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CP2 phosphoethanolamine transferase activity
GO:0051267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	addition of ethanolamine phosphate to mannose of GPI precursor CP2
GO:0051267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CP2 EtN-P transferase activity
GO:0051267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CP2 mannose-ethanolamine phosphotransferase activity
REACT:R-SSC-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Sus scrofa)
REACT:R-HSA-5651697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC34A2 does not cotransport Pi, 3Na+ (Homo sapiens)
REACT:R-DRE-420582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin-1 trans heterodimer interaction (Danio rerio)
REACT:R-RNO-8938073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Rattus norvegicus)
REACT:R-SSC-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Sus scrofa)
RHEA:62718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stemphyloxin II => stemphyloxin I
GO:0102305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-ol synthase activity
REACT:R-HSA-9024997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Homo sapiens)
RHEA:54844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexan-3-one + NADPH + O2 = ethyl butanoate + H2O + NADP(+)
REACT:R-SCE-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Saccharomyces cerevisiae)
RHEA:58687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 H(+) + NADPH + O2 <=> FADH2-C4alpha-hydroperoxide + NADP(+)
REACT:R-HSA-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Homo sapiens)
RHEA:43227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:37745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + prenyl-FMNH2 => dimethylallyl phosphate + FMNH2
RHEA:60369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urate(out) => urate(in)
RHEA:47185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-4615987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO2,3 (Bos taurus)
REACT:R-MMU-9710254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME oligomerizes (Mus musculus)
REACT:R-DME-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Drosophila melanogaster)
REACT:R-HSA-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)
REACT:R-CFA-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Canis familiaris)
REACT:R-CFA-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Canis familiaris)
RHEA:50198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2
REACT:R-GGA-353277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase (Gallus gallus)
GO:0004855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Schardinger enzyme activity
GO:0004855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthine:oxygen oxidoreductase activity
GO:0004855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthine:xanthine oxidase activity
GO:0004855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Homo sapiens)
GO:0004855	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hypoxanthine-xanthine oxidase activity
GO:0004855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthine oxidase activity
GO:0004855	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	xanthine oxidoreductase activity
GO:0004855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthine:O2 oxidoreductase activity
GO:0004855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	schardinger enzyme
REACT:R-HSA-8950179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B translocates from the cytosol to the extracellular region (Homo sapiens)
RHEA:43640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III"
RHEA:43640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + CoA
RHEA:43640	skos:prefLabel	"mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III"
RHEA:43640	skos:altLabel	"mycobacterial 3-oxoacyl-[acyl carrier protein] synthase III"
RHEA:28722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine(in) + H(+)(in) <=> adenine(out) + H(+)(out)
REACT:R-DDI-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)
REACT:R-HSA-173631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1s (Homo sapiens)
RHEA:24353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (R)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH
REACT:R-HSA-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)
REACT:R-BTA-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Bos taurus)
REACT:R-HSA-3234081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TFAP2A with SUMO1 (Homo sapiens)
RHEA:72066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate(out) + 2 Na(+)(out) <=> glycoursodeoxycholate(in) + 2 Na(+)(in)
RHEA:38747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate
REACT:R-HSA-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Homo sapiens)
REACT:R-GGA-3000310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PLK1 (Gallus gallus)
REACT:R-HSA-5662613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 exchanges zinc for copper (Homo sapiens)
REACT:R-HSA-9036011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)
REACT:R-DRE-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Danio rerio)
RHEA:52378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n)
REACT:R-BTA-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Bos taurus)
REACT:R-SCE-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Saccharomyces cerevisiae)
RHEA:29071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + formate + H(+) = a ubiquinol + CO2
REACT:R-RNO-199443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Rattus norvegicus)
REACT:R-CFA-1169406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host proteins (Canis familiaris)
GO:0047444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity
GO:0047444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANS converts ManNAc-6-P to Neu5Ac-9-P (Homo sapiens)
GO:0047444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate 9-phosphate synthetase activity
GO:0047444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialic acid 9-phosphate synthetase activity
GO:0047444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylneuraminate-9-phosphate synthase activity
GO:0047444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity
GO:0047444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate 9-phosphate lyase activity
GO:0047444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminic acid phosphate synthase activity
GO:0047444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity
REACT:R-DRE-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Danio rerio)
REACT:R-HSA-3238694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PORCN palmitoleoylates N-glycosyl WNTs (Homo sapiens)
REACT:R-HSA-2168897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP1 (CD91) binds Hemopexin:heme (Homo sapiens)
RHEA:42935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-2022383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)
REACT:R-XTR-4719448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO3 (Xenopus tropicalis)
REACT:R-CFA-9696323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNRs bind CNR agonists (Canis familiaris)
REACT:R-SCE-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Saccharomyces cerevisiae)
GO:0050300	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptidine kinase activity
GO:0050300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside 6-kinase activity
GO:0050300	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptomycin 6-phosphotransferase activity
GO:0050300	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptomycin 6-kinase activity
GO:0050300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APH(6) activity
GO:0050300	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptomycin 6-kinase (phosphorylating)
GO:0050300	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SM 6-kinase activity
GO:0050300	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptomycin 6-O-phosphotransferase activity
GO:0050300	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP:streptomycin 6-phosphotransferase activity
GO:0050300	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	streptidine kinase (phosphorylating)
REACT:R-XTR-114544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p115-RhoGEF activation of RHOA (Xenopus tropicalis)
RHEA:48674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:36011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-CFA-9009536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX5 binds ESR1:estrogen:TFF1 gene promoter (Canis familiaris)
RHEA:17548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] <=> [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]
RHEA:63644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-seryl-[protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)
REACT:R-SSC-418091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB1 (Sus scrofa)
RHEA:39515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 2C activity
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein threonine phosphatase activity
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatase I
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein serine/threonine phosphatase activity
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatase III
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine/threonine specific protein phosphatase activity
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase-2A
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 2B activity
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase-2C
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein serine phosphatase activity
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase-1
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 2A activity
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase-2B
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase type 1 activity
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	magnesium-dependent protein serine/threonine phosphatase activity
GO:0004722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatase II
REACT:R-MMU-8985591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2-bound ROBO1 binds MYO9B (Mus musculus)
REACT:R-HSA-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Homo sapiens)
RHEA:65034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a quinol + protoporphyrin IX => 3 a quinone + protoporphyrinogen IX
GO:0061522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity
REACT:R-DRE-180038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Danio rerio)
RHEA:25898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CO2 => H(+) + malonate
RHEA:43476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoate + O2 = 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate
REACT:R-DME-2672334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNN channels transport extracellular Na+ to cytosol (Drosophila melanogaster)
RHEA:11070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O
GO:0099508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage gated ion channel activity involved in regulation of presynaptic membrane potential
GO:0099508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential
GO:0099508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential
GO:0099508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
GO:0099508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential
REACT:R-RNO-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Rattus norvegicus)
REACT:R-RNO-3132737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate ETS1 and ETS2 (Rattus norvegicus)
RHEA:50233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-2064406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Rattus norvegicus)
REACT:R-DDI-74207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Dictyostelium discoideum)
RHEA:24166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]
REACT:R-HSA-8874195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L4 (Homo sapiens)
REACT:R-CFA-5686286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Canis familiaris)
GO:0099529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
REACT:R-DRE-5683831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCDC59 binds TTF1 (Danio rerio)
RHEA:59781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine
RHEA:28403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A
RHEA:11090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + triphosphate => H2O + trimetaphosphate
REACT:R-GGA-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)
REACT:R-SSC-373747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of nephrin by FYN (Sus scrofa)
RHEA:47967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate
RHEA:65335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + verruculide A <=> chrodrimanin E + H2O + NADP(+)
RHEA:30925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+) => (R)-glycerate + ADP-alpha-D-glucose
REACT:R-RNO-2248891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARSA translocates to the lysosome (Rattus norvegicus)
REACT:R-XTR-983145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Xenopus tropicalis)
REACT:R-BTA-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Bos taurus)
RHEA:69100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
RHEA:45345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside NORint (d18:1(4E)) + H(+) + UDP
RHEA:52918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate
GO:0005536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose binding
REACT:R-HSA-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Homo sapiens)
REACT:R-DRE-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Danio rerio)
REACT:R-HSA-3965450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits PFN1 (Homo sapiens)
REACT:R-HSA-5658092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIAH1, SIAH2 bind SNCAIP (Homo sapiens)
REACT:R-BTA-5654730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Bos taurus)
REACT:R-BTA-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Bos taurus)
REACT:R-CFA-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Canis familiaris)
RHEA:18452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + arsenite + H2O <=> AH2 + arsenate + H(+)
REACT:R-HSA-5635855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Homo sapiens)
REACT:R-RNO-5635102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 is internalized (Rattus norvegicus)
GO:0016886	skos:prefLabel	"Forming phosphoric ester bonds"
GO:0016886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming phosphoric ester bonds"
GO:0016886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase activity, forming phosphoric ester bonds
REACT:R-SCE-9638125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G1P to G6P (Saccharomyces cerevisiae)
REACT:R-SSC-5340226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB dioxygenates NO (Sus scrofa)
REACT:R-HSA-200423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Homo sapiens)
REACT:R-DME-6788611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYKK phosphorylates 5HLYS (Drosophila melanogaster)
RHEA:60191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate
REACT:R-MMU-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Mus musculus)
RHEA:63425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-phospholactate + GTP + H(+) => (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate
REACT:R-HSA-8850529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGS proteins bind GNB5 and CCT/TRiC (Homo sapiens)
RHEA:32847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol
RHEA:34988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(in) => (S)-lactate(out)
GO:0140506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoplasmic reticulum-autophagosome adaptor activity
GO:0140506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	autophagosome-ER anchor
GO:0140506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	autophagosome-endoplasmic reticulum anchor
GO:0140506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER- autophagosome anchor
REACT:R-GGA-391151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47:SKAP2 binds FYB (Gallus gallus)
RHEA:46310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-5686073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-3Y-SHC1 (Drosophila melanogaster)
REACT:R-SSC-5432849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds TLR4:LY96 (Sus scrofa)
RHEA:29996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + putrescine(out) => ADP + H(+) + phosphate + putrescine(in)
REACT:R-BTA-5696356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSCAR binds collagen and SP-D (Bos taurus)
REACT:R-GGA-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Gallus gallus)
RHEA:50477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + L-cysteinyl-[PqsD protein] => CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]
RHEA:45922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA
REACT:R-DRE-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Danio rerio)
REACT:R-BTA-71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Bos taurus)
RHEA:11973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(2+) + 6 H2O + O2 => 12 H(+) + 4 iron(III) oxide-hydroxide
RHEA:48878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O
RHEA:49736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NAD(+)
REACT:R-MMU-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Mus musculus)
RHEA:10193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sulfate(out) => ADP + H(+) + phosphate + sulfate(in)
REACT:R-GGA-9718020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PTGFR agonists (Gallus gallus)
REACT:R-HSA-5637795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)
REACT:R-BTA-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Bos taurus)
REACT:R-RNO-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Rattus norvegicus)
REACT:R-RNO-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Rattus norvegicus)
REACT:R-RNO-6784735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR bind to Clathrin (Rattus norvegicus)
RHEA:47771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-3640874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-RibC-AXIN is degraded by the proteasome (Sus scrofa)
REACT:R-DRE-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Danio rerio)
RHEA:49189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d => a 3-vinylbacteriochlorophyllide d + H2O
RHEA:38056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + phytol => CDP + H(+) + phytyl phosphate
RHEA:43108	skos:prefLabel	"nitrous-oxide reductase"
RHEA:43108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + N2 = 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide
RHEA:43108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrous-oxide reductase"
RHEA:44207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoate + ATP + CoA <=> 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate
REACT:R-HSA-8933258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LSR trimer binds LDL (Homo sapiens)
GO:0062064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	box C/D snoRNP complex binding
REACT:R-HSA-9687828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-GlcNAcylation of RIPK3 (TLR4 signaling) (Homo sapiens)
RHEA:32303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-homocitrate = (2R,3S)-homoisocitrate
RHEA:18792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine 6-phosphate <=> D-galactosamine 6-phosphate
REACT:R-CEL-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)
REACT:R-CFA-3266566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) (Canis familiaris)
RHEA:41807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxobutanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxybutanoyl-[ACP] + NADP(+)
GO:0015142	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sodium:dicarboxylate/tricarboxylate symporter activity
GO:0015142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tricarboxylic acid transmembrane transporter activity
GO:0102550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity
GO:0102550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine
RHEA:66717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate => (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate
RHEA:36672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z)-hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine
GO:0008962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phosphatidylglycerol phosphate + H2O = a phosphatidylglycerol + phosphate
GO:0008962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylglycerol phosphatase activity
GO:0008962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylglycerol phosphate phosphatase activity
GO:0008962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylglycerophosphatase activity
GO:0008962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylglycerophosphate phosphohydrolase activity
GO:0008962	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGP phosphatase activity
RHEA:54784	skos:prefLabel	"pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase"
RHEA:54784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase"
RHEA:54784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
RHEA:54784	skos:altLabel	"P2TMN nickel chelatase"
RHEA:58813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
RHEA:12729	skos:altLabel	"meso-zeaxanthin isomerase"
RHEA:12729	skos:prefLabel	"lutein isomerase"
RHEA:12729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutein = (3R,3'S)-zeaxanthin
RHEA:12729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lutein isomerase"
REACT:R-HSA-157640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEXT2 is cleaved to produce NICD2 (Homo sapiens)
REACT:R-BTA-8858252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDLBP binds HDL (Bos taurus)
REACT:R-CFA-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Canis familiaris)
REACT:R-SSC-75010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser 216 by Chk1 (Sus scrofa)
REACT:R-SSC-6803063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial LPS, PGN (Sus scrofa)
REACT:R-CFA-71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Canis familiaris)
REACT:R-BTA-879930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 is recruited by JAK2 (Bos taurus)
RHEA:46972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydrobisanhydrobacterioruberin = AH2 + bisanhydrobacterioruberin
RHEA:24407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA
REACT:R-MMU-6785898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R binds JAK2 (Mus musculus)
REACT:R-HSA-191971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)
REACT:R-BTA-418850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 (Bos taurus)
RHEA:35527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-ethylmaleimide + NADH = N-ethylsuccinimide + NAD(+)
RHEA:43405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP
RHEA:66604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in double-stranded DNA + NH4(+)
RHEA:34062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agroclavine + NADP(+) <=> didehydroagroclavine + H(+) + NADPH
REACT:R-SSC-114256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS:APAF1 binds procaspase-9 (Sus scrofa)
RHEA:47104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + glycine + H2O = 5,6,7,8-tetrahydromethanopterin + L-serine
RHEA:46307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + a fatty acyl-CoA = an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)
REACT:R-GGA-8864036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates PDGFRB at Y1021 (Gallus gallus)
RHEA:42782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine
REACT:R-DRE-2130478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of invariant chain trimer and MHC II alpha beta dimer (Danio rerio)
RHEA:29808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-leucine(out) => ADP + H(+) + L-leucine(in) + phosphate
RHEA:55173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + hexanoyl-CoA + O2 => 2-hydroxyhexanoyl-CoA + CO2 + succinate
RHEA:31234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanal + H2O + NAD(+) <=> 4-acetamidobutanoate + 2 H(+) + NADH
RHEA:36302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + ATP + CoA <=> (E)-caffeoyl-CoA + AMP + diphosphate
RHEA:61216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)
REACT:R-BTA-2559568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Bos taurus)
RHEA:69674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin 7-O-beta-D-glucoside + H2O <=> (2S)-naringenin + beta-D-glucose
RHEA:29109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + ubiquinol-8 => H(+) + NADH + ubiquinone-8
REACT:R-CFA-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Canis familiaris)
REACT:R-MMU-9701485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds JAK3 (Mus musculus)
RHEA:72364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + hydrogencarbonate(in) => chloride(in) + hydrogencarbonate(out)
GO:0048028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polygalacturonide binding
GO:0048028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galacturonan binding
REACT:R-CFA-5638012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D dissociates from ARL13B:INPP5E (Canis familiaris)
REACT:R-GGA-2065357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)
REACT:R-RNO-9668395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CC2D1B (Rattus norvegicus)
RHEA:47239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:17879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guaiacol + H(+) + S-adenosyl-L-homocysteine => a catechol + S-adenosyl-L-methionine
RHEA:23285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyl diphosphate => dimethylallyl diphosphate
REACT:R-XTR-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Xenopus tropicalis)
RHEA:11104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine = H(+) + hercynine + S-adenosyl-L-homocysteine
GO:2001084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinofuranose binding
GO:0018729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionate-CoA:lactoyl-CoA transferase activity
GO:0018729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionate coenzyme A-transferase activity
GO:0018729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionate CoA-transferase activity
GO:0018729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionyl CoA:acetate CoA transferase activity
GO:0018729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:propanoate CoA-transferase activity
GO:0018729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionyl-CoA transferase activity
REACT:R-DRE-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Danio rerio)
RHEA:67679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine
REACT:R-DRE-9006870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT phosphorylation (Danio rerio)
REACT:R-CFA-352052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Canis familiaris)
RHEA:19891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + H(+) + UTP
REACT:R-CFA-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Canis familiaris)
REACT:R-DME-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Drosophila melanogaster)
REACT:R-BTA-380455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CDK11p58 to the centrosomes (Bos taurus)
RHEA:68149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octanone + H(+) + NADPH => (2R)-octan-2-ol + NADP(+)
RHEA:65741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + nonyl sufate + O2 => CO2 + H(+) + nonanal + succinate + sulfate
REACT:R-DME-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Drosophila melanogaster)
RHEA:16440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + RX <=> a halide anion + an S-substituted glutathione + H(+)
RHEA:35196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-quinate(in) => L-quinate(out)
RHEA:19110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose => 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)
RHEA:68841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate
REACT:R-GGA-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Gallus gallus)
REACT:R-SSC-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Sus scrofa)
REACT:R-RNO-4719413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO2 (Rattus norvegicus)
RHEA:45506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] => phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]
RHEA:39528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)
REACT:R-BTA-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Bos taurus)
REACT:R-CFA-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)
RHEA:53727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate
REACT:R-HSA-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Homo sapiens)
REACT:R-RNO-70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)
REACT:R-SSC-6814683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Sus scrofa)
REACT:R-RNO-193736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)
REACT:R-DME-209120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)
EC:1.1.1.14	skos:altLabel	"glucitol dehydrogenase"
EC:1.1.1.14	skos:altLabel	"polyol dehydrogenase"
EC:1.1.1.14	skos:altLabel	"sorbitol dehydrogenase"
EC:1.1.1.14	skos:prefLabel	"L-iditol 2-dehydrogenase"
EC:1.1.1.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-iditol 2-dehydrogenase"
REACT:R-XTR-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Xenopus tropicalis)
REACT:R-HSA-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Homo sapiens)
REACT:R-MMU-937034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino (Mus musculus)
GO:0102510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity
REACT:R-RNO-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)
REACT:R-BTA-2162019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to EXA4 by ALOX15 (Bos taurus)
RHEA:52129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)
REACT:R-RNO-9707516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM dissociates from MetHb (Rattus norvegicus)
RHEA:11778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:21956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vitexin beta-glucosyltransferase"
RHEA:21956	skos:prefLabel	"vitexin beta-glucosyltransferase"
RHEA:21956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside
RHEA:32326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-8867370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Rattus norvegicus)
RHEA:67567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + chenodeoxycholate <=> adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)
RHEA:52911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dimethylallyl-4-hydroxyphenylpyruvate + O2 <=> 3-dimethylallyl-4-hydroxymandelate + CO2
REACT:R-RNO-156808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Rattus norvegicus)
RHEA:11164	skos:prefLabel	"phosphatidylethanolamine N-methyltransferase"
RHEA:11164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
RHEA:11164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylethanolamine N-methyltransferase"
RHEA:60281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:68506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-beta-farnesene + diphosphate => (2Z,6Z)-farnesyl diphosphate
RHEA:59701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellopentaono-1,5-lactone + H2O => D-cellopentaonate + H(+)
RHEA:61031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	itaconate + L-cysteinyl-[protein] <=> S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]
GO:0047589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminopentanoate:2-oxoglutarate aminotransferase activity
GO:0047589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-aminovalerate transaminase activity
GO:0047589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminovalerate aminotransferase activity
GO:0047589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-aminovalerate aminotransferase activity
GO:0047589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminovalerate transaminase activity
REACT:R-GGA-192422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular PTL:colipase (Gallus gallus)
REACT:R-DRE-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Danio rerio)
RHEA:69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline = A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide
REACT:R-DRE-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Danio rerio)
RHEA:23037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 inosine + O2 => 2 5'-dehydroinosine + 2 H2O
REACT:R-CFA-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Canis familiaris)
RHEA:69166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N-(2-carboxyethyl)putrescine + NADH => H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+)
GO:1990464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-2-hydroxyacid dehydrogenase (quinone) activity
GO:1990464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lactate:quinone oxidoreductase activity
GO:1990464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-hydroxyacid:quinone oxidoreductase activity
GO:1990464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-hydroxy acid dehydrogenase activity
GO:1990464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity
GO:1990464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lactate dehydrogenase activity
GO:1990464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lactate dehydrogenase (quinone) activity
REACT:R-RNO-193653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF homodimer binds to p75NTR (Rattus norvegicus)
REACT:R-DRE-6786012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Danio rerio)
RHEA:33287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + spermidine = 1-pyrroline + AH2 + propane-1,3-diamine
RHEA:61520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dopamine = 3-tyramine + A + H2O
REACT:R-DRE-9668597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase:primase binds G-strand of the telomere (Danio rerio)
RHEA:50104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-taurine
REACT:R-BTA-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Bos taurus)
REACT:R-RNO-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Rattus norvegicus)
REACT:R-RNO-9638078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from keratan sulfate (Rattus norvegicus)
GO:0036384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine-diphosphatase activity
GO:0036384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP phosphatase activity
GO:0036384	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CDP diphosphatase activity
GO:0036384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP + H2O = CMP + H(+) + phosphate
GO:0036384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDPase activity
GO:0036384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine diphosphatase activity
RHEA:14344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + glyoxylate + H(+) <=> 2-hydroxy-3-oxoadipate + CO2
REACT:R-RNO-170087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Rattus norvegicus)
RHEA:48772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a = 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O
REACT:R-MMU-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Mus musculus)
RHEA:10421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + taurine => L-alanine + sulfoacetaldehyde
REACT:R-HSA-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Homo sapiens)
REACT:R-HSA-9622367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA mRNA is translated to yield CEBPA protein (Homo sapiens)
REACT:R-CFA-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Canis familiaris)
REACT:R-SSC-8852354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)
RHEA:11593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonacolin L-[lovastatin nonaketide synthase] + H2O => dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]
RHEA:49922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + O-octanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-octanoyl-(R)-carnitine(in)
RHEA:52441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)
REACT:R-MMU-1605723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Mus musculus)
REACT:R-CFA-1234177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)
RHEA:50403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[PqsC protein] + octanoyl-CoA <=> CoA + S-octanoyl-L-cysteinyl-[PqsC protein]
REACT:R-MMU-5669012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA binds EDAR (Mus musculus)
RHEA:70945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine(out) => L-isoleucine(in)
REACT:R-GGA-5682992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A,B bind H4K20Me2 (Gallus gallus)
REACT:R-DME-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Drosophila melanogaster)
RHEA:14294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + NAD(+) => D-glucono-1,5-lactone + H(+) + NADH
RHEA:33322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:58380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + nonan-1-ol = H(+) + NADPH + nonanal
REACT:R-BTA-5610766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Bos taurus)
REACT:R-DDI-5672958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from KSR1:MARK3 (Dictyostelium discoideum)
RHEA:43701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesoate + S-adenosyl-L-methionine => methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine
RHEA:37287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-leucine(out) = ADP + H(+) + L-alanyl-L-leucine(in) + phosphate
REACT:R-SCE-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Saccharomyces cerevisiae)
REACT:R-DRE-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)
REACT:R-GGA-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Gallus gallus)
REACT:R-DDI-9759549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Dictyostelium discoideum)
REACT:R-CFA-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Canis familiaris)
REACT:R-SSC-420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretin receptor binds secretin (Sus scrofa)
REACT:R-XTR-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Xenopus tropicalis)
RHEA:48475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1a + H2O <=> ganglioside GD1a + N-acetylneuraminate
GO:0008445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aspartate:oxygen oxidoreductase (deaminating)
GO:0008445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate oxidase activity
GO:0008445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic oxidase activity
GO:0008445	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aspartic oxidase activity
RHEA:44228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-decenoate + ATP + CoA = 9-decenoyl-CoA + AMP + diphosphate
RHEA:59145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate
RHEA:20019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + H(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2
REACT:R-HSA-9755306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)
REACT:R-GGA-201628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at DSVD (85) (Gallus gallus)
REACT:R-SSC-3295580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPM4,5 transport extracellular Na+ to cytosol (Sus scrofa)
RHEA:32394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,4R)-dihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH
RHEA:59341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A => 1'-hydroxy-demethylspheroidene + AH2
REACT:R-BTA-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Bos taurus)
REACT:R-XTR-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Xenopus tropicalis)
REACT:R-MMU-3222237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMYD2 methylates TP53 (Mus musculus)
REACT:R-DDI-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Dictyostelium discoideum)
REACT:R-RNO-5687123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S115 MAPKAPK5 translocates to the cytosol (Rattus norvegicus)
RHEA:47022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O
RHEA:43250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O
RHEA:71909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide => GDP + NAD(+)
RHEA:11426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain] => ATP + L-threonyl-[myosin heavy-chain]
RHEA:42245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + propanoyl-CoA => 3-oxopentanoyl-[ACP] + CO2 + CoA
REACT:R-CFA-2022056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPG and CSPG translocate to the lysosome for degradation (Canis familiaris)
RHEA:18353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Na(+)/K(+)-exchanging ATPase"
RHEA:18353	skos:altLabel	"Na(+)/K(+)-ATPase"
RHEA:18353	skos:altLabel	"sodium/potassium-transporting ATPase"
RHEA:18353	skos:prefLabel	"Na(+)/K(+)-exchanging ATPase"
RHEA:18353	skos:altLabel	"sodium pump"
RHEA:18353	skos:altLabel	"Na,K-activated ATPase"
RHEA:18353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate
REACT:R-XTR-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Xenopus tropicalis)
REACT:R-CFA-5696049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
RHEA:67717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 oxidized [2Fe-2S]-[protein] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]
REACT:R-CFA-76052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIA To type 1 Promoter (Canis familiaris)
REACT:R-CEL-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Caenorhabditis elegans)
REACT:R-SCE-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Saccharomyces cerevisiae)
GO:0034850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isooctane monooxygenase activity
REACT:R-DME-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Drosophila melanogaster)
REACT:R-MMU-199839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate RSK (Mus musculus)
RHEA:38258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + succinyl-CoA <=> (S)-malyl-CoA + succinate
REACT:R-DRE-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Danio rerio)
REACT:R-HSA-9616214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)
REACT:R-HSA-9694492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)
GO:0033933	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextran alpha-1,2 debranching enzyme
GO:0033933	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity
GO:0033933	skos:prefLabel	"branched-dextran exo-1,2-alpha-glucosidase"
GO:0033933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"branched-dextran exo-1,2-alpha-glucosidase"
GO:0033933	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextran 1,2-alpha-glucosidase activity
GO:0033933	skos:altLabel	"dextran alpha-1,2 debranching enzyme"
GO:0033933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-dextran exo-1,2-alpha-glucosidase activity
RHEA:21199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine <=> L-methionine + tetrahydropteroyltri-L-glutamate
RHEA:44934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA
REACT:R-BTA-203565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)
REACT:R-CEL-75825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of Cyclin D1 (Caenorhabditis elegans)
REACT:R-CFA-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Canis familiaris)
REACT:R-CEL-201425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Caenorhabditis elegans)
RHEA:18176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-octopamine <=> (4-hydroxyphenyl)acetaldehyde + NH4(+)
RHEA:27747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-cysteine => CO2 + cysteamine
RHEA:54839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptan-2-one + NADPH + O2 <=> H2O + NADP(+) + pentyl acetate
REACT:R-DRE-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Danio rerio)
REACT:R-MMU-114252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-3 by the apoptosome (Mus musculus)
RHEA:70862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(in) + L-glutamine(out) + Na(+)(out) <=> L-asparagine(out) + L-glutamine(in) + Na(+)(in)
RHEA:11494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-yl phosphate + CO2 => H(+) + O-phospho-L-threonine
RHEA:14029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + menaquinone-8 + selenite = menaquinol-8 + selenate
RHEA:14029	skos:prefLabel	"selenate reductase"
RHEA:14029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + selenite = AH2 + selenate
RHEA:14029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"selenate reductase"
RHEA:21527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + acetyl-CoA + H2O <=> (2S)-2-isopropylmalate + CoA + H(+)
RHEA:60865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-8869506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)
REACT:R-SSC-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Sus scrofa)
RHEA:69745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-benzylsuccinyl-CoA + succinate => (S)-2-benzylsuccinate + succinyl-CoA
RHEA:70578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic UMP + H2O <=> H(+) + UMP
REACT:R-CFA-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Canis familiaris)
REACT:R-MMU-73806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIR + CO2 => CAIR (Mus musculus)
REACT:R-SSC-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Sus scrofa)
REACT:R-RNO-72095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internal Methylation of mRNA (Rattus norvegicus)
RHEA:10085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + O2 => 3-carboxy-cis,cis-muconate + 2 H(+)
REACT:R-XTR-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-RNO-352379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Rattus norvegicus)
REACT:R-RNO-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Rattus norvegicus)
REACT:R-BTA-4647593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP400 binds CDKN1A promoter (Bos taurus)
REACT:R-CFA-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Canis familiaris)
REACT:R-GGA-8938231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds CREBBP (Gallus gallus)
REACT:R-DRE-379382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates DA to DOPAC (Danio rerio)
RHEA:52011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
REACT:R-DDI-110349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of UNG glycosylase by APEX1 at the AP site (Dictyostelium discoideum)
REACT:R-MMU-430183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK binds PAK (Mus musculus)
RHEA:63175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oyl-CoA <=> (25R)-3-oxocholest-4-en-26-oyl-CoA
RHEA:12988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
GO:0050529	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyneuridine aldehyde esterase activity
GO:0050529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyneuridine-aldehyde esterase activity
GO:0050529	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyneuridine aldehyde hydrolase (decarboxylating)
GO:0050529	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PNAE activity
REACT:R-BTA-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Bos taurus)
RHEA:49929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Homo sapiens)
REACT:R-XTR-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Xenopus tropicalis)
RHEA:16878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine + H(+) => CO2 + hypotaurine
REACT:R-SSC-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Sus scrofa)
RHEA:24991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitroate + H2O + 2 oxidized [adrenodoxin]
REACT:R-XTR-8987179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Xenopus tropicalis)
REACT:R-CFA-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)
REACT:R-BTA-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)
RHEA:14430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [oligopeptide](in) + ATP + H2O => a [oligopeptide](out) + ADP + H(+) + phosphate
REACT:R-SSC-212713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLC-gamma1 dissociates from EGFR (Sus scrofa)
GO:0004825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine translase activity
GO:0004825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine:tRNAMet ligase (AMP-forming)
GO:0004825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine-tRNA ligase activity
GO:0004825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionyl-transfer RNA synthetase activity
GO:0004825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionyl-tRNA synthetase activity
GO:0004825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionyl-transfer ribonucleate synthetase activity
GO:0004825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionyl-transfer ribonucleic acid synthetase activity
GO:0004825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MetRS activity
REACT:R-DDI-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Dictyostelium discoideum)
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH--rubredoxin oxidoreductase activity
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH:rubredoxin reductase activity
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rubredoxin--nicotinamide adenine dinucleotide reductase activity
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH--rubredoxin reductase activity
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPNH-rubredoxin reductase activity
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rubredoxin:NAD+ oxidoreductase activity
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:rubredoxin oxidoreductase activity
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rubredoxin--NAD reductase activity
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity
GO:0015044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rubredoxin-NAD+ reductase activity
REACT:R-RNO-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)
REACT:R-DRE-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Danio rerio)
RHEA:38945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O
RHEA:55967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)
RHEA:23880	skos:altLabel	"phosphoenolpyruvate--protein phosphatase"
RHEA:23880	skos:altLabel	"sugar--PEP phosphotransferase enzyme I"
RHEA:23880	skos:altLabel	"phosphoenolpyruvate sugar phosphotransferase enzyme I"
RHEA:23880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoenolpyruvate--protein phosphotransferase"
RHEA:23880	skos:altLabel	"enzyme I of the phosphotransferase system"
RHEA:23880	skos:altLabel	"phosphopyruvate--protein factor phosphotransferase"
RHEA:23880	skos:prefLabel	"phosphoenolpyruvate--protein phosphotransferase"
RHEA:23880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate
RHEA:23880	skos:altLabel	"phosphopyruvate--protein phosphotransferase"
RHEA:59379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate <=> 4-amino-4-deoxyprephenate
GO:0047209	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity
GO:0047209	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity
GO:0047209	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity
GO:0047209	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose coniferyl alcohol glucosyltransferase activity
GO:0047209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coniferyl-alcohol glucosyltransferase activity
REACT:R-CEL-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Caenorhabditis elegans)
REACT:R-CEL-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Caenorhabditis elegans)
REACT:R-MMU-174446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap from the C-strand (Mus musculus)
RHEA:33000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:25903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabino-hex-3-ulose 6-phosphate <=> beta-D-fructose 6-phosphate
RHEA:70727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O = 6-sulfo-alpha-D-quinovose + glycerol
REACT:R-HSA-70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Homo sapiens)
REACT:R-DRE-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Danio rerio)
RHEA:17857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate
REACT:R-HSA-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)
GO:0001098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	basal transcription machinery binding
GO:0019135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)
GO:0019135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)
GO:0019135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DOHH activity
GO:0019135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyhypusine hydroxylase activity
GO:0019135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyhypusine monooxygenase activity
GO:0019135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyhypusine dioxygenase activity
RHEA:40101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA
RHEA:18256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NADP(+) <=> CO2 + NADPH + pyruvate
REACT:R-MMU-1605591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Mus musculus)
RHEA:16598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NH4(+) + UTP => ADP + CTP + 2 H(+) + phosphate
RHEA:66592	skos:altLabel	"E.coli endonuclease III"
RHEA:66592	skos:altLabel	"endodeoxyribonuclease (apurinic or apyrimidinic)"
RHEA:66592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA-(apurinic or apyrimidinic site) lyase"
RHEA:66592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)
RHEA:66592	skos:altLabel	"phage-T4 UV endonuclease"
RHEA:66592	skos:prefLabel	"DNA-(apurinic or apyrimidinic site) lyase"
RHEA:66592	skos:altLabel	"Micrococcus luteus UV endonuclease"
RHEA:66592	skos:altLabel	"deoxyribonuclease (apurinic or apyrimidinic)"
RHEA:66592	skos:altLabel	"AP endonuclease class I"
RHEA:66592	skos:altLabel	"AP lyase"
RHEA:46371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-GGA-8852019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET bound PI3K generates PIP3 (Gallus gallus)
REACT:R-MMU-2404200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2 binds IGF1R (Mus musculus)
REACT:R-DME-9708533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)
RHEA:71974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyglutarate(out) + 3 Na(+)(out) <=> 3-hydroxyglutarate(in) + 3 Na(+)(in)
REACT:R-CFA-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Canis familiaris)
REACT:R-HSA-196417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of desmosterol to cholesterol (Homo sapiens)
REACT:R-CFA-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Canis familiaris)
RHEA:28333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + ITP <=> H(+) + IDP + phosphate
GO:0051723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 (Homo sapiens)
GO:0051723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein carboxyl methylesterase activity
GO:0051723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PME activity
GO:0051723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein methyl-esterase activity
GO:0051723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein carboxylic ester hydrolase activity
GO:0051723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein methylesterase activity
REACT:R-RNO-109338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Rattus norvegicus)
REACT:R-DRE-1676149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Danio rerio)
RHEA:53767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholate + lithocholoyl-CoA <=> allocholoyl-CoA + lithocholate
RHEA:16513	skos:altLabel	"lactate oxygenase"
RHEA:16513	skos:altLabel	"lactate oxidase"
RHEA:16513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + O2 = acetate + CO2 + H2O
RHEA:16513	skos:prefLabel	"lactate 2-monooxygenase"
RHEA:16513	skos:altLabel	"lactate oxidative decarboxylase"
RHEA:16513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactate 2-monooxygenase"
REACT:R-DRE-5655466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Danio rerio)
RHEA:55411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + CTP <=> [phosphate](n+1) + CDP
RHEA:55147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH
RHEA:67786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol => 2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol
RHEA:57667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0005222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular cAMP activated cation channel activity
GO:0005222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular adenosine 3',5'-cyclophosphate activated cation channel activity
GO:0005222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular cyclic AMP activated cation channel activity
GO:0005222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular cAMP-activated cation channel activity
GO:0005222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular 3',5' cAMP activated cation channel activity
GO:0005222	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	HCN channel activity
GO:0005222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular 3',5'-cAMP activated cation channel activity
GO:0005222	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hyperpolarization-activated cyclic nucleotide-gated channel activity
RHEA:32008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene
REACT:R-CFA-1296024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in neuroendocrine cells (Canis familiaris)
RHEA:46153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + a plastoquinone => 15,9'-di-cis-phytofluene + a plastoquinol
RHEA:53990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[myosin light chain] + phosphate => H2O + O-phospho-L-threonyl-[myosin light chain]
RHEA:43569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADH
REACT:R-GGA-9691421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK binds BTK inhibitors (Gallus gallus)
RHEA:53385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + NAD(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH
REACT:R-RNO-9687828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-GlcNAcylation of RIPK3 (TLR4 signaling) (Rattus norvegicus)
RHEA:57797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite
REACT:R-HSA-1169404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)
REACT:R-GGA-199443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Gallus gallus)
REACT:R-RNO-418442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Rattus norvegicus)
RHEA:37502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-HSA-6803999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNO2 produces N2O3 (Homo sapiens)
REACT:R-CEL-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Caenorhabditis elegans)
GO:0010465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nerve growth factor receptor activity
GO:0010465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF receptor activity
GO:0010465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nerve growth factor receptor activity
RHEA:36112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A1 + S-adenosyl-L-methionine => O-methyl gibberellin A1 + S-adenosyl-L-homocysteine
RHEA:31600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NADH + O2 + thymine => (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)
REACT:R-HSA-5607732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TAK1 autophosphorylates (Homo sapiens)
REACT:R-HSA-1362485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GH (Homo sapiens)
RHEA:23443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoate + H2O <=> 4-hydroxybenzoate + chloride + H(+)
REACT:R-MMU-5689111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 autoubiquitinates (Mus musculus)
REACT:R-SSC-193668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR and RHOA-GDI interact (Sus scrofa)
RHEA:28024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + octanoyl-[ACP] => ATP + holo-[ACP] + octanoate
REACT:R-HSA-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
REACT:R-SPO-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Schizosaccharomyces pombe)
RHEA:10469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 5-phosphate + phosphate => acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotyrosine phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein phosphotyrosine phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[phosphotyrosine]protein phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotyrosylprotein phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotyrosine protein phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine O-phosphate phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tyrosine phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotyrosine histone phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPT-phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-tyrosine-phosphate phosphohydrolase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoprotein phosphatase (phosphotyrosine) activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosylprotein phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTP-phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-tyrosine-phosphatase activity
GO:0004725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTPase activity
RHEA:37889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide => S-adenosyl-L-methionine + small RNA 3'-end nucleotide
RHEA:44058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA
REACT:R-SSC-6798374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DYRK2 phosphorylates TP53 (Sus scrofa)
REACT:R-HSA-9609689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG) (Homo sapiens)
REACT:R-CEL-9035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysS248-MPST:TXN2 dissociates (Caenorhabditis elegans)
REACT:R-RNO-379048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)
RHEA:63176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ibuprofenoyl-CoA = (2R)-ibuprofenoyl-CoA
EC:3.4.11.23	skos:prefLabel	"PepB aminopeptidase"
EC:3.4.11.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"PepB aminopeptidase"
EC:3.4.11.23	skos:altLabel	"aminopeptidase B"
EC:3.4.11.23	skos:altLabel	"peptidase B"
RHEA:22775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuconate <=> 2-dehydro-3-deoxy-L-fuconate + H2O
REACT:R-MMU-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Mus musculus)
REACT:R-MMU-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Mus musculus)
REACT:R-DME-4755524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1I2 with SUMO3 (Drosophila melanogaster)
RHEA:48209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:41833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-[ACP] + H(+) + NADPH => hexanoyl-[ACP] + NADP(+)
REACT:R-CFA-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Canis familiaris)
RHEA:23187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate
REACT:R-RNO-6805785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates PHF20 (Rattus norvegicus)
REACT:R-HSA-5686483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
REACT:R-BTA-391939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP receptor can bind thromboxane (Bos taurus)
REACT:R-BTA-8855915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Bos taurus)
REACT:R-HSA-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Homo sapiens)
REACT:R-BTA-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Bos taurus)
REACT:R-GGA-449073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-3 cleaves pro-interleukin-16 (Gallus gallus)
RHEA:15902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate => (2R)-3-phosphoglycerate
RHEA:65915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + pyruvate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine
REACT:R-DRE-5669035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF11 binds TNFRSF11A, B (Danio rerio)
RHEA:72956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + nicotinate(out) => 2 Na(+)(in) + nicotinate(in)
RHEA:37247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thymidine 3'-monophosphate = phosphate + thymidine
RHEA:38201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:28264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP => 3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose
RHEA:34940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + menaquinone-8 + selenite => menaquinol-8 + selenate
REACT:R-HSA-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Homo sapiens)
REACT:R-GGA-163798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein Z to protein Z (Gallus gallus)
REACT:R-XTR-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Xenopus tropicalis)
REACT:R-SPO-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Schizosaccharomyces pombe)
REACT:R-HSA-9025152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Homo sapiens)
RHEA:18330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,3R,5S)-sabinol + NAD(+) => (1S,5S)-sabinone + H(+) + NADH
GO:0022853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	active ion transmembrane transporter activity
REACT:R-CEL-2681667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Caenorhabditis elegans)
REACT:R-PFA-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Plasmodium falciparum)
REACT:R-BTA-9026006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Bos taurus)
REACT:R-DRE-9661799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)
REACT:R-PFA-4827383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)
RHEA:39370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)
RHEA:57146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine
REACT:R-DME-4411402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NLK (Drosophila melanogaster)
GO:1990943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTS1 element binding
GO:1990943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mating type region replication fork barrier binding
GO:1990943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTS1 barrier binding
RHEA:54048	skos:prefLabel	"4-epi-cubebol synthase"
RHEA:54048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate
RHEA:54048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-epi-cubebol synthase"
GO:0140699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic GMP-AMP synthase activity
GO:0140699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-GMP-AMP synthase activity
REACT:R-CFA-192123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates CHOL (Canis familiaris)
REACT:R-SPO-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)
GO:1990276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA 5'-methyltransferase activity
REACT:R-DRE-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Danio rerio)
REACT:R-RNO-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Rattus norvegicus)
REACT:R-HSA-9694727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of protein 3a (Homo sapiens)
REACT:R-DRE-200423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Danio rerio)
RHEA:37152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
RHEA:65016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorothalonil + H2O = 4-hydroxychlorothalonil + chloride + 2 H(+)
REACT:R-MMU-877269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS-1 and SOCS-3 binds to p-JAK2 (Mus musculus)
RHEA:44604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)
REACT:R-DME-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Drosophila melanogaster)
RHEA:61685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycero-2-phosphocholine + H2O => glycerol + H(+) + phosphocholine
RHEA:64010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoyl-CoA
RHEA:33622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + tetradecanoate <=> AMP + diphosphate + tetradecanoyl-CoA
RHEA:66371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methyl-3,7-dioxodecanedioyl-CoA + CoA <=> 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA
RHEA:25433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-ribopyranose => beta-D-ribofuranose
REACT:R-CFA-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Canis familiaris)
REACT:R-DME-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Drosophila melanogaster)
RHEA:49437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + deoxycholoyl-CoA => choloyl-CoA + deoxycholate
GO:0102530	skos:prefLabel	"aclacinomycin methylesterase"
GO:0102530	skos:altLabel	"aclacinomycin methyl esterase"
GO:0102530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aclacinomycin methylesterase"
GO:0102530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol
GO:0102530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin T methylesterase activity
RHEA:66325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide(out) => iodide(in)
RHEA:41035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA
REACT:R-CFA-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Canis familiaris)
RHEA:47811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:36109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-methyl gibberellin A4 + S-adenosyl-L-homocysteine => gibberellin A4 + S-adenosyl-L-methionine
GO:0106334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-dRP lyase
GO:0106334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O = (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)
GO:0106334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-dRP lyase activity
GO:0106334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-deoxyribose phosphate lyase activity
RHEA:71471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)
RHEA:70110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-5-carboxymethyl-tetronate + o-quinone methide <=> H(+) + penilactone D
RHEA:23827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) <=> 2,3-dihydroxybenzoate + H(+) + NADH
REACT:R-HSA-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Homo sapiens)
RHEA:45577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA
REACT:R-CFA-912757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S585-IL3RB binds 14-3-3 proteins (Canis familiaris)
RHEA:33516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5,6-dihydroxyindole + O2 => 2 H2O + 2 indole-5,6-quinone
RHEA:63598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine
RHEA:56804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-SSC-4827382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)
REACT:R-SSC-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Sus scrofa)
RHEA:34928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + selenodiglutathione => glutathione + glutathioselenol + NADP(+)
REACT:R-MMU-264871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin B1 (Mus musculus)
RHEA:57537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate => a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)
REACT:R-XTR-5654418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS2 (Xenopus tropicalis)
RHEA:12386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + uracil => 5,6-dihydrouracil + O2
RHEA:24638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH => H2 + NAD(+)
REACT:R-RNO-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)
RHEA:72962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) <=> (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)
RHEA:63975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydropyriculol <=> AH2 + pyriculol
REACT:R-CEL-9619376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK1 binds calmodulin (Caenorhabditis elegans)
REACT:R-CFA-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Canis familiaris)
REACT:R-CFA-8932276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Canis familiaris)
REACT:R-CEL-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Caenorhabditis elegans)
RHEA:22035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxalomalate <=> glyoxylate + oxaloacetate
RHEA:71408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] => 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in miRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine
REACT:R-SSC-2530453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vitronectin (VTN) binds to C5b:C6:C7 (Sus scrofa)
RHEA:14198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + NH4(+) => ADP + H(+) + L-asparagine + phosphate
REACT:R-MMU-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Mus musculus)
REACT:R-HSA-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Homo sapiens)
RHEA:23846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-sedoheptulose 7-phosphate + H(+) => ATP + sedoheptulose
REACT:R-HSA-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Homo sapiens)
RHEA:28180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	colnelenate + H2O => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate
REACT:R-BTA-9020271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Bos taurus)
RHEA:57883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP
REACT:R-SSC-5693615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Sus scrofa)
REACT:R-HSA-9636128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of SCP, Triplex (TRI) complex, CVC complex, and Accessory Proteins from the cytoplasm into the nucleous (Homo sapiens)
REACT:R-MMU-392202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 12:Gi complex (Mus musculus)
REACT:R-SSC-8950537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Sus scrofa)
REACT:R-BTA-6807134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)
RHEA:70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-SSC-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Sus scrofa)
GO:0046027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity
GO:0046027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDAT activity
GO:0046027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipid:diacylglycerol acyltransferase activity
REACT:R-PFA-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Plasmodium falciparum)
REACT:R-HSA-374701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DCC by Fyn (Homo sapiens)
REACT:R-CEL-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Caenorhabditis elegans)
REACT:R-MMU-4570553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO2,3 (Mus musculus)
REACT:R-XTR-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Xenopus tropicalis)
RHEA:53493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) => 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)
GO:0050033	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnono-gamma-lactonase activity
GO:0050033	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnono-1,4-lactone lactonohydrolase activity
GO:0050033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnono-1,4-lactonase activity
GO:0050033	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamno-gamma-lactonase activity
RHEA:72296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate(out) + 3 Na(+)(out) => malate(in) + 3 Na(+)(in)
GO:0102703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (1S,4R)-camphene + diphosphate
GO:0102703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	camphene synthase activity
GO:0102703	skos:prefLabel	"(-)-camphene synthase"
GO:0102703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-camphene synthase"
REACT:R-CFA-9679421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCD1 binds PDCD1 inhibitors (Canis familiaris)
REACT:R-MMU-6803875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds CDK1 and CCNB1 (Mus musculus)
RHEA:35198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-quinate(in) <=> L-quinate(out)
REACT:R-CFA-9624272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMPs cleave HB-EGF (Canis familiaris)
RHEA:20412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + riboflavin <=> D-glucose + FMN
RHEA:57858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-6-hydroxyferuloyl-CoA + CO2 + succinate => (E)-feruloyl-CoA + 2-oxoglutarate + O2
RHEA:11140	skos:prefLabel	"phosphomannomutase"
RHEA:11140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphomannomutase"
RHEA:11140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
RHEA:11140	skos:altLabel	"phosphomannose mutase"
REACT:R-DME-9755304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUL1 ubiquitinates UBXN7 (Drosophila melanogaster)
RHEA:67959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-chloropropanoate + H2O <=> (R)-lactate + chloride + H(+)
REACT:R-XTR-9624800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LBR (Xenopus tropicalis)
REACT:R-RNO-8939201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR dimerizes (Rattus norvegicus)
RHEA:17329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S,4R)-borneol + NAD(+) = (1R,4R)-camphor + H(+) + NADH
RHEA:17329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-borneol dehydrogenase"
RHEA:17329	skos:prefLabel	"(+)-borneol dehydrogenase"
RHEA:35175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	novobiocin(in) = novobiocin(out)
REACT:R-HSA-879594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO4C1 mediates the transport of digoxin (Homo sapiens)
RHEA:28043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + pyruvate => acetyl-CoA + CO2 + NADH
REACT:R-HSA-751019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)
REACT:R-GGA-8849881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM2 associate with AMPA and NMDA receptors (Gallus gallus)
REACT:R-DME-214857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
REACT:R-RNO-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Rattus norvegicus)
REACT:R-MMU-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Mus musculus)
REACT:R-SSC-5686430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81 binds EME1, EME2 (Sus scrofa)
RHEA:13952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [rubredoxin] <=> NADPH + 2 oxidized [rubredoxin]
REACT:R-RNO-2022381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)
REACT:R-DME-209227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)
REACT:R-RNO-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Rattus norvegicus)
RHEA:17783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + L-methionine => H2O + N-formyl-L-methionine
REACT:R-PFA-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Plasmodium falciparum)
REACT:R-CEL-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Caenorhabditis elegans)
GO:0102438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laricitrin 4'-O-methyltransferase activity
RHEA:49226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin]
RHEA:53482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol + NADP(+) => 3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH
REACT:R-SSC-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Sus scrofa)
RHEA:67494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+) => a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O
REACT:R-CFA-170153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)
RHEA:53576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Sus scrofa)
RHEA:15705	skos:altLabel	"phenylacetyl-CoA:acceptor oxidoreductase"
RHEA:15705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinone + H2O + phenylacetyl-CoA = 2 a ubiquinol + phenylglyoxylyl-CoA
RHEA:15705	skos:prefLabel	"phenylacetyl-CoA dehydrogenase"
RHEA:15705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetyl-CoA dehydrogenase"
REACT:R-CFA-426223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cation influx mediated by TRPC3/6/7 (Canis familiaris)
REACT:R-HSA-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Homo sapiens)
REACT:R-SSC-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Sus scrofa)
RHEA:62063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)
RHEA:28410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH
RHEA:45653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-HSA-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-BTA-2430535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL phosphorylates ENSA (Bos taurus)
RHEA:30444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)
REACT:R-RNO-909719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STAT2 to p-IFNAR1 (Rattus norvegicus)
REACT:R-BTA-2327746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 aggregation (Bos taurus)
REACT:R-HSA-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)
RHEA:19746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine
REACT:R-BTA-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Bos taurus)
REACT:R-MMU-3928627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB phosphorylates TIAM1 (Mus musculus)
REACT:R-MMU-5676595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAFs bind RANK:RANKL (Mus musculus)
REACT:R-RNO-1299297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of THIK (Rattus norvegicus)
REACT:R-DDI-174374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
RHEA:57069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate + ATP => 3-oxoisoapionate 4-phosphate + ADP + H(+)
REACT:R-CFA-5654667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
REACT:R-CFA-177107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion and activation of the latent large complex of TGF-beta-1 (Canis familiaris)
RHEA:56381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O
REACT:R-PFA-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Plasmodium falciparum)
RHEA:40411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)
RHEA:22288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose
RHEA:22288	skos:altLabel	"endo-glucosylceramidase"
RHEA:22288	skos:altLabel	"oligoglycosylglucosylceramide glycohydrolase"
RHEA:22288	skos:altLabel	"endoglycoceramidase"
RHEA:22288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endoglycosylceramidase"
RHEA:22288	skos:prefLabel	"endoglycosylceramidase"
REACT:R-SSC-1250264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP binds reduced thioredoxin (Sus scrofa)
GO:0050630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(iso)eugenol O-methyltransferase activity
GO:0050630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity
GO:0050630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoeugenol O-methyltransferase activity
REACT:R-MMU-976743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates plasma Factor H-bound C3b (Mus musculus)
REACT:R-SSC-2730903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of TRAF6 (Sus scrofa)
REACT:R-BTA-2467811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of sister chromatids (Bos taurus)
REACT:R-CFA-6804253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates JMY (Canis familiaris)
REACT:R-RNO-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Rattus norvegicus)
REACT:R-BTA-8984023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Bos taurus)
GO:0140358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type transmembrane transporter activity
GO:0140358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPase
GO:0140358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1-E2 ATPase
REACT:R-DME-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Drosophila melanogaster)
REACT:R-BTA-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Bos taurus)
REACT:R-BTA-9758674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 oxidizes PREDN,PREDL (Bos taurus)
REACT:R-MMU-5607756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomer autoubiquitinates (Mus musculus)
REACT:R-CFA-9755937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces LAN to 24,25-dhLAN (Canis familiaris)
RHEA:37257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuccinamate + AH2 + NH4(+) => A + D-asparagine + H2O
GO:0102070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxyoleate peroxygenase activity
RHEA:48815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
REACT:R-HSA-1168456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor binds Lyn (Homo sapiens)
REACT:R-DRE-6787677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUOM isomerises alpha-Fuc to beta-Fuc (Danio rerio)
REACT:R-GGA-5683385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of BRCA1-A complex at DNA DSBs (Gallus gallus)
REACT:R-RNO-2730904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Rattus norvegicus)
REACT:R-GGA-8941618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)
REACT:R-SCE-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Saccharomyces cerevisiae)
GO:0004309	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	metaphosphatase activity
GO:0004309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid phosphoanhydride phosphohydrolase activity
GO:0004309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Gra-Pase activity
GO:0004309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exopolyphosphatase activity
GO:0004309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exopolypase activity
GO:0004309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyphosphate phosphohydrolase activity
REACT:R-XTR-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)
RHEA:54529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate => D-ribose 5-phosphate
RHEA:36059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydrourocanate = AH2 + urocanate
RHEA:36059	skos:prefLabel	"urocanate reductase"
RHEA:36059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"urocanate reductase"
RHEA:44621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine
REACT:R-BTA-6786092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4:IL4R:JAK2 binds IL2RG:JAK3 (Bos taurus)
GO:0090586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity
REACT:R-CEL-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Caenorhabditis elegans)
REACT:R-CFA-8984021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Canis familiaris)
REACT:R-CEL-170153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Caenorhabditis elegans)
REACT:R-HSA-3149494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC:cob(II)alamin binds MMADHC (Homo sapiens)
RHEA:45221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] => Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-CFA-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Canis familiaris)
REACT:R-HSA-4332236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL neddylates TGFBR2 (Homo sapiens)
REACT:R-BTA-194678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 demethylates LNSOL (Bos taurus)
REACT:R-SCE-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Saccharomyces cerevisiae)
REACT:R-HSA-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
REACT:R-MMU-5218916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPK2/3 phosphorylates HSP27 (Mus musculus)
REACT:R-DRE-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Danio rerio)
REACT:R-MMU-8951966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates RUNX3 (Mus musculus)
RHEA:28401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate <=> L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate
REACT:R-DRE-9020259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Danio rerio)
RHEA:58231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparaginyl-[protein] + NAD(+) <=> H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide
REACT:R-BTA-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Bos taurus)
RHEA:38044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-9653595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B binds BCL2L1 (Danio rerio)
REACT:R-DDI-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Dictyostelium discoideum)
REACT:R-BTA-5654640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
RHEA:18079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide => L-arginyl-[dinitrogen reductase] + NAD(+)
REACT:R-GGA-5218827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)
RHEA:15373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	columbamine + S-adenosyl-L-methionine = H(+) + palmatine + S-adenosyl-L-homocysteine
RHEA:15373	skos:prefLabel	"columbamine O-methyltransferase"
RHEA:15373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"columbamine O-methyltransferase"
RHEA:54262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[protein] + O2
RHEA:70865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-threonine(out) + Na(+)(in) => L-glutamine(out) + L-threonine(in) + Na(+)(out)
RHEA:59543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2
REACT:R-CEL-5625426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde IFT (Caenorhabditis elegans)
REACT:R-RNO-265427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Rattus norvegicus)
GO:0106264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]
GO:0106264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein serine kinase activity (using GTP as donor)
REACT:R-CFA-2454240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-FCERI gamma subunit (Canis familiaris)
RHEA:57031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)
EC:1.3.1.122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-8-oxocitronellyl enol synthase"
EC:1.3.1.122	skos:altLabel	"iridoid synthase"
EC:1.3.1.122	skos:prefLabel	"(S)-8-oxocitronellyl enol synthase"
RHEA:71154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one <=> (E)-caffeoylpyruvate + CO2 + hnu
REACT:R-DRE-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Danio rerio)
REACT:R-SSC-965067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THTPA:Mg2+ hydrolyzes ThTP to TDP (Sus scrofa)
REACT:R-HSA-6786652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIT1 hydrolyses CHIT to 3xADGP (Homo sapiens)
REACT:R-XTR-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Xenopus tropicalis)
RHEA:45862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA
RHEA:14617	skos:prefLabel	"CoA-glutathione reductase"
RHEA:14617	skos:altLabel	"coenzyme A disulfide-glutathione reductase"
RHEA:14617	skos:altLabel	"NADPH:CoA-glutathione oxidoreductase"
RHEA:14617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glutathione + NADP(+) = CoA-glutathione + H(+) + NADPH
RHEA:14617	skos:altLabel	"coenzyme A glutathione disulfide reductase"
RHEA:14617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CoA-glutathione reductase"
RHEA:14617	skos:altLabel	"NADPH-dependent coenzyme A-SS-glutathione reductase"
RHEA:14617	skos:altLabel	"CoA-glutathione reductase (NADPH)"
REACT:R-SSC-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Sus scrofa)
RHEA:69980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-dehydrokanamycin A + H(+) + NADPH <=> kanamycin A + NADP(+)
REACT:R-RNO-199863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate NR4A1 (NUR77) (Rattus norvegicus)
REACT:R-DDI-975185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Dictyostelium discoideum)
RHEA:54609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]
REACT:R-SSC-5682965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Sus scrofa)
REACT:R-HSA-451900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RB binds JAK1 (Homo sapiens)
REACT:R-HSA-9685179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 N protein binds TRIM25 (Homo sapiens)
RHEA:49229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) => diphosphate + geranylgeranyl-bacteriochlorophyllide a
RHEA:23789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + AMP + diphosphate
REACT:R-XTR-2029458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV1 to p-6Y-SYK (Xenopus tropicalis)
REACT:R-RNO-5218642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Rattus norvegicus)
REACT:R-SPO-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
GO:0047403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligosaccharide lacto-N-biosylhydrolase activity
GO:0047403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lacto-N-biosidase activity
REACT:R-XTR-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Xenopus tropicalis)
REACT:R-HSA-391150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)
REACT:R-CFA-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)
REACT:R-XTR-444171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR2 binds carboxylates (Xenopus tropicalis)
REACT:R-BTA-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Bos taurus)
REACT:R-CFA-109341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Canis familiaris)
REACT:R-RNO-9006870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT phosphorylation (Rattus norvegicus)
REACT:R-HSA-188985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose + H2O => 2 D-glucose (Homo sapiens)
REACT:R-RNO-8869633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NR to yield NMN (Rattus norvegicus)
REACT:R-HSA-167419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex releases GDP (Homo sapiens)
REACT:R-BTA-8981657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds PTPRZ1 (Bos taurus)
REACT:R-SSC-1889955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT dimers transfer GlcA to tetrasaccharide linker (Sus scrofa)
REACT:R-GGA-6806629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tonofilament bundles (Gallus gallus)
RHEA:64836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethanol + acetyl-CoA = CoA + phenethyl acetate
REACT:R-HSA-8963915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D binds VDR (Homo sapiens)
RHEA:18083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + pentalenene => (2E,6E)-farnesyl diphosphate
RHEA:65945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + CTP + S-adenosyl-L-methionine => 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine
REACT:R-DME-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Drosophila melanogaster)
REACT:R-CFA-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
RHEA:62136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + GTP = dGDP + GDP
REACT:R-CEL-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Caenorhabditis elegans)
RHEA:18767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a sphingomyelin => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
RHEA:71526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine(out) <=> adenine(in)
RHEA:72844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA(in) + ADP(out) => 3'-dephospho-CoA(out) + ADP(in)
REACT:R-DME-209072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLL kinase binds to TL:MYD88:TUB 'signalling complex' (Drosophila melanogaster)
RHEA:39450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)
RHEA:31819	skos:prefLabel	"5-epi-alpha-selinene synthase"
RHEA:31819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-epi-alpha-selinene synthase"
RHEA:31819	skos:altLabel	"8a-epi-alpha-selinene synthase"
RHEA:31819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = 5-epi-alpha-selinene + diphosphate
REACT:R-HSA-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Homo sapiens)
RHEA:72973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline(in) + 2 Na(+)(in) => 5-oxo-L-proline(out) + 2 Na(+)(out)
RHEA:39657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2
REACT:R-DRE-8934446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC phosphorylates SHC1 (Danio rerio)
RHEA:30155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + 2 Fe(3+) = FAD + 2 Fe(2+) + 3 H(+)
RHEA:67204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyltryptamine = acetate + tryptamine
REACT:R-GGA-173680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C5 (Gallus gallus)
REACT:R-CFA-5244692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)
REACT:R-SPO-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Schizosaccharomyces pombe)
REACT:R-XTR-350578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO1 interaction with ODC (Xenopus tropicalis)
RHEA:19554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan => indole + NH4(+) + pyruvate
REACT:R-GGA-3769394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CBY1 (Gallus gallus)
REACT:R-HSA-3209160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERKs phosphorylate ERF (Homo sapiens)
RHEA:64227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + uridine(34) in tRNA <=> 5-hydroxyuridine(34) in tRNA + A + H2O
REACT:R-DRE-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Danio rerio)
REACT:R-MMU-741411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates NEMO (Mus musculus)
RHEA:71177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(in) + glycine betaine(in) + 3 Na(+)(in) => 2 chloride(out) + glycine betaine(out) + 3 Na(+)(out)
REACT:R-MMU-5687653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)
RHEA:15325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-3-phosphate 1-O-acyltransferase"
RHEA:15325	skos:altLabel	"glycerol-3-phosphate O-acyltransferase"
RHEA:15325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA
RHEA:15325	skos:prefLabel	"glycerol-3-phosphate 1-O-acyltransferase"
REACT:R-XTR-9667569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,2 bind AVPR antagonists (Xenopus tropicalis)
GO:0102746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydrogeranylgeranyl-PP reductase activity
REACT:R-XTR-381518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAAP-A proteolyzes IGF:IGFBP4 (Xenopus tropicalis)
RHEA:26247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + fusicocca-2,10(14)-diene => geranylgeranyl diphosphate
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-hydroxy amino acid dehydratase activity
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-serine dehydratase activity
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-serine deaminase activity
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-serine ammonia-lyase (pyruvate-forming)
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-serine dehydration activity
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine ammonia-lyase activity
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-hydroxyaminoacid dehydratase activity
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-serine hydro-lyase (deaminating) activity
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-serine dehydrase activity
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-serine dehydratase (deaminating) activity
GO:0008721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-serine hydrolase activity
REACT:R-SSC-8943987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCUBE1, SCUBE3 oligomerize (Sus scrofa)
REACT:R-DRE-9025969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Danio rerio)
RHEA:67584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-DRE-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Danio rerio)
REACT:R-BTA-170044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Bos taurus)
GO:0009019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate guanine 1-methyltransferase activity
GO:0009019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity
GO:0009019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (guanine-N1-)-methyltransferase activity
GO:0009019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA guanine 1-methyltransferase activity
GO:0009019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity
REACT:R-XTR-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-SCE-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Saccharomyces cerevisiae)
RHEA:14359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + FMN + H(+) => ATP + riboflavin
GO:0031874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 3 proteinase activated receptor binding
GO:0031874	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 3 proteinase activated receptor ligand
RHEA:26135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)
REACT:R-DME-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Drosophila melanogaster)
GO:0034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type III transforming growth factor beta receptor binding
GO:0034714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta ligand binding to type III receptor
GO:0034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor beta receptor type III binding
GO:0034714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	betaglycan binding
GO:0034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type IIII TGF-beta binding
GO:0034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGF-beta type III binding
RHEA:52657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) => a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH
REACT:R-HSA-9663752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNN2 transports K+ from the cytosol to the extracellular region (Homo sapiens)
RHEA:63701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolate + UDP-alpha-D-glucuronate => mycophenolic acid O-acyl-beta-D-glucuronide + UDP
RHEA:23554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanal + H(+) + NADH => 2-methylpropane-1,2-diol + NAD(+)
RHEA:46358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + octadecanoate + reduced [NADPH--hemoprotein reductase]
RHEA:12811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O => 4 catechol + 3 O2
RHEA:41384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-BTA-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Bos taurus)
RHEA:55208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine 1-phosphate = (2R)-hydroxyhexadecanal + phosphoethanolamine
GO:0061653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISG15 conjugating enzyme activity
GO:0061653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
REACT:R-HSA-622415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 binds NEMO (Homo sapiens)
REACT:R-XTR-5690702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN phosphorylates CD22 (Xenopus tropicalis)
REACT:R-BTA-9705794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 binds SRD5A2 inhibitors (Bos taurus)
REACT:R-BTA-9640168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Bos taurus)
REACT:R-DME-5654416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:pFRS binds GRB2:SOS1 (Drosophila melanogaster)
RHEA:66686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH]
RHEA:64564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-epi-ilicicolin H = ilicicolin H
RHEA:49448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-1,2-mannosidase"
RHEA:49448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O = alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose
RHEA:49448	skos:prefLabel	"beta-1,2-mannosidase"
GO:0052655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine transaminase activity
GO:0052655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine aminotransferase activity
REACT:R-CEL-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Caenorhabditis elegans)
REACT:R-DRE-9036301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Danio rerio)
REACT:R-HSA-9028273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH3 spontaneously dehydrates to PGJ3 (Homo sapiens)
RHEA:35222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dADP + H2O <=> 8-oxo-dAMP + H(+) + phosphate
REACT:R-XTR-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Xenopus tropicalis)
REACT:R-CFA-981497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Canis familiaris)
RHEA:39470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)
RHEA:20789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + phosphate => ADP-beta-D-ribose 1''-phosphate + H(+) + nicotinamide
RHEA:54953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + nonanoate => AMP + diphosphate + nonanoyl-CoA
REACT:R-SSC-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Sus scrofa)
REACT:R-DRE-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Danio rerio)
RHEA:51039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> 2 H2O + indole-3-pyruvate imine dimer
RHEA:67394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-AMP + diphosphate + H(+) => 2-oxo-ATP + H2O
REACT:R-DRE-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)
RHEA:68658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxycholesterol + NADP(+) => 7-oxocholesterol + H(+) + NADPH
REACT:R-DRE-1638032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Danio rerio)
RHEA:60178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate => 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O
REACT:R-SCE-927830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)
RHEA:10839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + questin <=> demethylsulochrin + NADP(+)
RHEA:31029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucopyranosyl trans-(+)-abscisate + UDP => 2-trans-(+)-abscisate + UDP-alpha-D-glucose
REACT:R-GGA-5250930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH recruits histone acetyltransferases (Gallus gallus)
REACT:R-XTR-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Xenopus tropicalis)
REACT:R-BTA-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Bos taurus)
RHEA:10568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"luteolin 7-O-glucuronosyltransferase"
RHEA:10568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-beta-D-glucuronide + UDP
RHEA:10568	skos:prefLabel	"luteolin 7-O-glucuronosyltransferase"
REACT:R-RNO-4551648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO1 (Rattus norvegicus)
REACT:R-SSC-388830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds ICOS (Sus scrofa)
REACT:R-HSA-437084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT3 transports zinc into synaptic vesicles (Homo sapiens)
REACT:R-SPO-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Schizosaccharomyces pombe)
REACT:R-CEL-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Caenorhabditis elegans)
REACT:R-CEL-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Caenorhabditis elegans)
RHEA:19039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an ethanediol => an epoxide + H2O
RHEA:48477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1a (d18:1(4E)) + H2O => ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate
REACT:R-GGA-8933452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE dimer binds phosphorylated DENND1 proteins (Gallus gallus)
REACT:R-CFA-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Canis familiaris)
RHEA:20108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-D-fructose 6-phosphate <=> AMP + beta-D-fructose 1,6-bisphosphate + H(+)
REACT:R-BTA-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Bos taurus)
REACT:R-HSA-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Homo sapiens)
REACT:R-XTR-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)
GO:0015194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine transmembrane transporter activity
GO:0015194	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	serine transporter activity
GO:0015194	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine permease activity
GO:0015194	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine/serine:sodium symporter activity
GO:0015194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Homo sapiens)
GO:0015194	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-serine transporter activity
RHEA:45645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-hexadecanoylsphing-4-enine + phosphocholine
RHEA:58643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine <=> a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine
REACT:R-XTR-5218847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 binds NCK (Xenopus tropicalis)
REACT:R-DDI-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)
RHEA:49338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + spheroiden-2-one => 2,2-dihydroxyspheroidene
REACT:R-HSA-1602398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Homo sapiens)
REACT:R-DRE-2213241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of nonameric complex (Danio rerio)
REACT:R-DDI-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Dictyostelium discoideum)
RHEA:11989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Canis familiaris)
RHEA:15156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + UDP-alpha-D-glucose <=> 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP
EC:1.14.13.127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-(3-hydroxy-phenyl)propanoic acid hydroxylase"
EC:1.14.13.127	skos:prefLabel	"3-(3-hydroxy-phenyl)propanoic acid hydroxylase"
REACT:R-HSA-8878186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 (Homo sapiens)
REACT:R-DRE-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Danio rerio)
RHEA:33086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehypoxanthine futalosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine
RHEA:36070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-6B + S-adenosyl-L-methionine <=> Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine
REACT:R-HSA-1222325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carboxymycobactin and mycobactin exchange their iron load (Homo sapiens)
GO:0035243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein arginine omega-N symmetric methylase activity
GO:0035243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine omega-N symmetric methyltransferase activity
GO:0035243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II PRMT activity
GO:0035243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein arginine omega-N symmetric methyltransferase activity
GO:0035243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II protein arginine methyltransferase activity
GO:0035243	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)
REACT:R-SSC-6786650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDHD1,2 hydrolyse PA (Sus scrofa)
RHEA:36017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-1181354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERBERUS binds NODAL (Homo sapiens)
RHEA:10523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP
REACT:R-GGA-2428926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Gallus gallus)
RHEA:66525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(in) + monodehydro-L-ascorbate radical(out) => L-ascorbate(out) + monodehydro-L-ascorbate radical(in)
RHEA:44868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline
GO:0018732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfolactone hydrolase activity
GO:0018732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulpholactone hydrolase activity
REACT:R-HSA-9707977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Homo sapiens)
REACT:R-MMU-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Mus musculus)
RHEA:72739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) = chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)
REACT:R-HSA-74987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTF-I binds to the Sal Box (Homo sapiens)
REACT:R-HSA-9683769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-glycosylation of 3a is terminated (Homo sapiens)
REACT:R-RNO-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Rattus norvegicus)
RHEA:68801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nigerose => alpha-D-glucose + D-glucose
GO:0004963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	follicle-stimulating hormone receptor activity
GO:0004963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FSH receptor activity
GO:0004963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	follicle stimulating hormone receptor activity
REACT:R-MMU-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Mus musculus)
RHEA:51853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
RHEA:42348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)
GO:0008241	skos:prefLabel	"Peptidyl-dipeptidases"
GO:0008241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Peptidyl-dipeptidases"
GO:0008241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-dipeptidase activity
REACT:R-DME-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Drosophila melanogaster)
REACT:R-BTA-6806957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET receptor dimerizes (Bos taurus)
REACT:R-XTR-5610752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R translocates to the nucleus (Xenopus tropicalis)
REACT:R-HSA-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Homo sapiens)
REACT:R-XTR-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Xenopus tropicalis)
RHEA:57160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate
RHEA:35607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin + NADP(+) = diacetyl + H(+) + NADPH
REACT:R-HSA-110354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)
RHEA:18860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-9021068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs bind CAVs (Gallus gallus)
REACT:R-SSC-6784735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR bind to Clathrin (Sus scrofa)
EC:4.1.2.49	skos:prefLabel	"L-allo-threonine aldolase"
EC:4.1.2.49	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-allo-threonine aldolase"
REACT:R-DME-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Drosophila melanogaster)
RHEA:45786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + NH4(+) => 2 H2O + phenylpropanonitrile
RHEA:50952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloro-L-tryptophan + AH2 + O2 = A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin
REACT:R-DRE-9652580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Danio rerio)
REACT:R-HSA-9685162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 M protein interacts with TRAF3 (Homo sapiens)
REACT:R-DME-209224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)
RHEA:60054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2
REACT:R-DRE-193455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Danio rerio)
RHEA:69832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campestanol + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:1901974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerate transmembrane transporter activity
REACT:R-RNO-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)
RHEA:35177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	novobiocin(out) => novobiocin(in)
REACT:R-HSA-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Homo sapiens)
GO:0004520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endodeoxyribonuclease activity
GO:0004520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endonuclease G activity
GO:0004520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA nicking activity
REACT:R-SSC-388814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds CD28 (Sus scrofa)
REACT:R-BTA-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Bos taurus)
RHEA:58810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + GMP + 2 H(+) => 2',3'-cGAMP + 2 H2O
REACT:R-MMU-5649708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 recruits POLB to incised AP site (Mus musculus)
RHEA:30958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9'-di-cis-zeta-carotene + 2 a quinone <=> 7,7',9,9'-tetra-cis-lycopene + 2 a quinol
RHEA:36636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine
RHEA:67699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanedioyl-CoA <=> CoA + H(+) + hexadecanedioate
REACT:R-MMU-1604360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP14 (Mus musculus)
REACT:R-RNO-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Rattus norvegicus)
REACT:R-CEL-1676204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Caenorhabditis elegans)
RHEA:68196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoylglycerol + tetradecanoyl-CoA = 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA
GO:0070780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosphingosine-1-phosphate phosphatase activity
GO:0070780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosphingosine-1-phosphate phosphohydrolase activity
GO:0070780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine-1-phosphate phosphatase activity
REACT:R-RNO-5666008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCAI binds SRF:MKL1 (Rattus norvegicus)
RHEA:40540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:45809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate => (2S,3R)-dihydroxy-5-oxohexanedioate + H2O
REACT:R-RNO-202203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PI3K to plasma membrane (Rattus norvegicus)
REACT:R-CFA-983146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Canis familiaris)
REACT:R-HSA-9705794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 binds SRD5A2 inhibitors (Homo sapiens)
REACT:R-SSC-8950387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX binds EBI3 (Sus scrofa)
GO:0052592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With an iron-sulfur protein as acceptor"
GO:0052592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
GO:0052592	skos:prefLabel	"With an iron-sulfur protein as acceptor"
GO:0052592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulphur protein as acceptor
REACT:R-MMU-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Mus musculus)
REACT:R-CFA-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Canis familiaris)
RHEA:64149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)
GO:0048403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neurotrophin TRKB receptor activity
GO:0048403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brain-derived neurotrophic factor binding
GO:0048403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDNF binding
REACT:R-RNO-5694436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 and MIA3 dissociate from procollagen VII vesicle (Rattus norvegicus)
REACT:R-CFA-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Canis familiaris)
GO:0072570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose binding
GO:0072570	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ADP-ribose binding
REACT:R-DDI-1678843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein translation regulator 4EHP (Dictyostelium discoideum)
REACT:R-CFA-8875568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 activates RAP1 (Canis familiaris)
RHEA:17960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate <=> H2O + propynoate
RHEA:66302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose
REACT:R-HSA-427383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9 (Homo sapiens)
REACT:R-XTR-5333051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA1 binds HSF1 (Xenopus tropicalis)
REACT:R-PFA-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Plasmodium falciparum)
REACT:R-DRE-9714363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC translocates to the endoplasmic reticulum membrane (Danio rerio)
REACT:R-MMU-2029458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV1 to p-6Y-SYK (Mus musculus)
RHEA:65671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine
RHEA:68124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a fatty acyl-[ACP] = a triacylglycerol + holo-[ACP]
REACT:R-GGA-205306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP1 and KIT (Gallus gallus)
REACT:R-RNO-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Rattus norvegicus)
REACT:R-HSA-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Homo sapiens)
RHEA:36117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-methyl gibberellin A3 + S-adenosyl-L-homocysteine => gibberellin A3 + S-adenosyl-L-methionine
REACT:R-CFA-5225602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR5 binds Me2sR3-replicative histone H3 (Canis familiaris)
REACT:R-MMU-381612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1 (Mus musculus)
REACT:R-XTR-9022314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates MECP2 (Xenopus tropicalis)
REACT:R-XTR-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Xenopus tropicalis)
RHEA:50079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Bos taurus)
RHEA:72761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A8 + CoA => anthocyanin A6 + malonyl-CoA
RHEA:35502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:65599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Rattus norvegicus)
REACT:R-DDI-428214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Dictyostelium discoideum)
RHEA:15155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(beta-D-glucosyloxy)benzoate + H(+) + UDP => 4-hydroxybenzoate + UDP-alpha-D-glucose
REACT:R-HSA-389969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-tubulin:GTP + Cofactor D ->  Beta-tubulin:GTP: Cofactor D (Homo sapiens)
REACT:R-HSA-5228508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates PML with SUMO1 (Homo sapiens)
RHEA:11165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-4420083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)
RHEA:69134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanal + H2O2 + NH4(+) => cadaverine + H2O + O2
RHEA:63962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisate(in) + ADP + H(+) + phosphate => abscisate(out) + ATP + H2O
REACT:R-HSA-8938853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 binds RUNX1 (Homo sapiens)
RHEA:32735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
RHEA:69282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropyl isothiocyanate + sulfate => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate
REACT:R-SSC-210289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-DAP12 (Sus scrofa)
REACT:R-SSC-77323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Sus scrofa)
RHEA:68162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CEL-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Caenorhabditis elegans)
REACT:R-XTR-5696945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates CCP110,ARRB (Xenopus tropicalis)
RHEA:44359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nogalaviketone <=> methyl nogalonate
REACT:R-SSC-192475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Sus scrofa)
RHEA:68414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-glutamate + NADPH => H2O + L-glutamate 5-semialdehyde + NADP(+)
REACT:R-HSA-9603437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds IRS1 (Homo sapiens)
REACT:R-BTA-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Bos taurus)
REACT:R-BTA-5610732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI3 (Bos taurus)
REACT:R-GGA-2468287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)
REACT:R-MMU-5621363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Mus musculus)
REACT:R-HSA-9656214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
REACT:R-HSA-9008894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPNs gene transcription and translation (Homo sapiens)
RHEA:52844	skos:altLabel	"UDP-glucose--vanillate 1-glucosyltransferase"
RHEA:52844	skos:prefLabel	"gallate 1-beta-glucosyltransferase"
RHEA:52844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gallate 1-beta-glucosyltransferase"
RHEA:52844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + UDP-alpha-D-glucose = 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP
REACT:R-DME-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Drosophila melanogaster)
REACT:R-RNO-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Rattus norvegicus)
GO:0102915	skos:altLabel	"piperitol synthase"
GO:0102915	skos:altLabel	"CYP81Q2"
GO:0102915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	piperitol synthase activity
GO:0102915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-piperitol/(+)-sesamin synthase"
GO:0102915	skos:altLabel	"CYP81Q1"
GO:0102915	skos:prefLabel	"(+)-piperitol/(+)-sesamin synthase"
GO:0102915	skos:altLabel	"sesamin synthase"
GO:0102915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0033852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thyroid-hormone aminotransferase activity
GO:0033852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,5-dinitrotyrosine aminotransferase activity
GO:0033852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thyroid hormone aminotransferase activity
GO:0033852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyroid-hormone transaminase activity
GO:0033852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity
GO:0033852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,5-dinitrotyrosine transaminase activity
REACT:R-CFA-1678716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(1) (Canis familiaris)
REACT:R-GGA-2465938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates atROL taken up by Muller cells (Gallus gallus)
REACT:R-GGA-216048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Gallus gallus)
RHEA:11649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol + H(+) + NADPH + O2 => 1,4-menthane-3,8-diol + H2O + NADP(+)
RHEA:69694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine <=> ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP
REACT:R-BTA-8864595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2B homodimer binds YEATS4 (Bos taurus)
RHEA:38900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)
RHEA:14797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)
REACT:R-RNO-8937613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHBP binds CRH (Rattus norvegicus)
RHEA:49576	skos:prefLabel	"GTP 3',8-cyclase"
RHEA:49576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine
RHEA:49576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GTP 3',8-cyclase"
REACT:R-CFA-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Canis familiaris)
REACT:R-BTA-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Bos taurus)
REACT:R-XTR-391913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR2 binds FPR2 ligands (Xenopus tropicalis)
RHEA:16842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-2 + S-adenosyl-L-methionine => H(+) + precorrin-3A + S-adenosyl-L-homocysteine
RHEA:22939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamine 6-phosphate <=> acetate + D-glucosamine 6-phosphate
REACT:R-DRE-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Danio rerio)
REACT:R-CFA-174706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Canis familiaris)
REACT:R-MMU-6805479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53RK phosphorylates TP53 (Mus musculus)
REACT:R-CFA-194187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-DDI-70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Dictyostelium discoideum)
REACT:R-MMU-8849055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARHGAP35 (Mus musculus)
RHEA:34379	skos:altLabel	"arabinogalactan galactofuranosyl transferase 1"
RHEA:34379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP
RHEA:34379	skos:prefLabel	"rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase"
RHEA:34379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase"
REACT:R-BTA-2250301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyrrole cross-links (Bos taurus)
REACT:R-DME-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Drosophila melanogaster)
RHEA:38657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + tulipalin B => 6-tuliposide B
RHEA:62923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol <=> 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal
RHEA:34969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate(out) => sn-glycerol 3-phosphate(in)
REACT:R-SSC-9020271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Sus scrofa)
REACT:R-SSC-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Sus scrofa)
RHEA:53369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(17) in tRNA + NADP(+) => H(+) + NADPH + uridine(17) in tRNA
RHEA:68393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + peracetic acid => acetate + H(+) + H2O2
REACT:R-RNO-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Rattus norvegicus)
RHEA:56479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
REACT:R-HSA-5229348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)
RHEA:31499	skos:prefLabel	"neolactotriaosylceramide beta-1,4-galactosyltransferase"
RHEA:31499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neolactotriaosylceramide beta-1,4-galactosyltransferase"
RHEA:31499	skos:altLabel	"lactotriaosylceramide beta-1,4-galactosyltransferase"
RHEA:31499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP
REACT:R-DRE-2562526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates OPTN (Danio rerio)
REACT:R-HSA-9694780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike translocates to ERGIC (Homo sapiens)
RHEA:22793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isonocardicin A => nocardicin A
REACT:R-MMU-180073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Mus musculus)
RHEA:29443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanine(in) = H(+)(out) + L-alanine(out)
RHEA:43716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP
RHEA:43716	skos:prefLabel	"[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase"
RHEA:43716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase"
RHEA:42663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose
REACT:R-SSC-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Sus scrofa)
REACT:R-CFA-5665982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Canis familiaris)
REACT:R-HSA-9694520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 binds VHL (Homo sapiens)
RHEA:23252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate
RHEA:62980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenamide + H2O = (9Z)-hexadecenoate + NH4(+)
RHEA:29237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + NAD(+) => a menaquinone + H(+) + NADH
REACT:R-MMU-904830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
REACT:R-XTR-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Xenopus tropicalis)
REACT:R-CEL-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
RHEA:23606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kievitone => kievitone hydrate
RHEA:33393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C20 sphinganine + phosphate => C20 sphinganine 1-phosphate + H2O
REACT:R-DDI-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Dictyostelium discoideum)
RHEA:17277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
RHEA:17277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphogluconate dehydratase"
RHEA:17277	skos:prefLabel	"phosphogluconate dehydratase"
RHEA:71266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-proline(out) + 2 Na(+)(out) <=> chloride(in) + L-proline(in) + 2 Na(+)(in)
RHEA:23954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + acetate => H2O + N-(2-phenylethyl)acetamide
REACT:R-SSC-1855225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Sus scrofa)
RHEA:59746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein] => (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein]
RHEA:47482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => deoxycholate + NADP(+)
RHEA:69696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menadione + NADH => menadiol + NAD(+)
RHEA:13463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+) => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2
REACT:R-RNO-390224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Rattus norvegicus)
REACT:R-MMU-199093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXADR binds to AMICA1 (Mus musculus)
REACT:R-CFA-3215295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates MDM2 (Canis familiaris)
RHEA:60023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene A
GO:0010296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenylcysteine methylesterase activity
REACT:R-HSA-5601922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complexed PIWIL2 binds cleaved transposon RNA (Homo sapiens)
GO:0002056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine binding
REACT:R-DME-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Drosophila melanogaster)
RHEA:19858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16alpha-hydroxysteroid + NADP(+) => a 16-oxosteroid + H(+) + NADPH
RHEA:36312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH
REACT:R-DDI-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Dictyostelium discoideum)
EC:3.4.14.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tripeptidyl-peptidase I"
EC:3.4.14.9	skos:altLabel	"tripeptidyl peptidase"
EC:3.4.14.9	skos:prefLabel	"tripeptidyl-peptidase I"
EC:3.4.14.9	skos:altLabel	"tripeptidyl aminopeptidase"
REACT:R-DRE-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Danio rerio)
GO:0016410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyltransferase activity
GO:0016410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A (Homo sapiens)
GO:0071950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced flavine-adenine dinucleotide binding
GO:0071950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced flavin adenine dinucleotide binding
GO:0071950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 binding
REACT:R-DME-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Drosophila melanogaster)
RHEA:70435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate
REACT:R-XTR-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Xenopus tropicalis)
RHEA:18806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-disulfide + [protein]-dithiol => [DsbA protein]-dithiol + [protein]-disulfide
RHEA:37454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA
RHEA:25951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CTP <=> a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)
REACT:R-CFA-8874685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds MET (Canis familiaris)
RHEA:60673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + nerol => H(+) + NADH + neral
REACT:R-SSC-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Sus scrofa)
RHEA:42510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-acetamidopentanoate + CO2 + H(+) + NADH => 6-acetamido-2-oxohexanoate + H2O + NAD(+)
REACT:R-BTA-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Bos taurus)
REACT:R-SSC-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Sus scrofa)
REACT:R-HSA-6795667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the cytosol (Homo sapiens)
RHEA:18340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + uracil <=> H2O + psi-UMP
REACT:R-MMU-9018499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and EP300 are recruited to TFF3 promoter (Mus musculus)
GO:1990450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linear polyubiquitin binding
GO:1990450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M1-linked ubiquitin chain binding
RHEA:48011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-CoA + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)
REACT:R-DDI-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Dictyostelium discoideum)
RHEA:72617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanyl-L-valine(in) => H(+)(out) + L-alanyl-L-valine(out)
REACT:R-MMU-169719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted CD14 binds LPS (Mus musculus)
REACT:R-MMU-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Mus musculus)
RHEA:67201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyltyramine => acetate + tyramine
REACT:R-SSC-162730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Sus scrofa)
RHEA:51150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + 2 H(+) + 2 reduced [azurin] => a primary alcohol + 2 oxidized [azurin]
REACT:R-BTA-9656893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1MW binds 11cRAL (Bos taurus)
RHEA:59891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chloro-L-lysine + AH2 + O2 <=> A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)
REACT:R-MMU-6805507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 binds AVEN (Mus musculus)
REACT:R-HSA-9009910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) binds p-S423,S425-SMAD3 (Homo sapiens)
REACT:R-BTA-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Bos taurus)
RHEA:40345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + tetradecanedioyl-CoA => 3-oxohexadecanedioyl-CoA + CoA
RHEA:29933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP
RHEA:57850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + fraxetin + succinate => 2-oxoglutarate + O2 + scopoletin
RHEA:41659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + NADP(+) <=> NADPH + sanguinarine
REACT:R-CEL-77342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Caenorhabditis elegans)
GO:0050395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity
GO:0050395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity
GO:0050395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity
GO:0050395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitexin beta-glucosyltransferase activity
GO:0050395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitexin b-glucosyltransferase activity
RHEA:71237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[3Fe-4S](0)-[protein] + Fe(3+)-[Dph3] => [3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3]
REACT:R-HSA-1989773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CPT2 (Homo sapiens)
REACT:R-HSA-5624473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Homo sapiens)
REACT:R-DRE-9709842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS binds TOMM70 (Danio rerio)
REACT:R-HSA-9683478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CQ, HCQ diffuses from cytosol to endocytic vesicle lumen (Homo sapiens)
REACT:R-CEL-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)
REACT:R-SSC-6793666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the nucleus (Sus scrofa)
RHEA:42585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:21937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + putrescine => H(+) + N-carbamoylputrescine + phosphate
RHEA:21284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH
REACT:R-CEL-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Caenorhabditis elegans)
RHEA:58378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanal + H(+) + NADPH => decan-1-ol + NADP(+)
REACT:R-CFA-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Canis familiaris)
REACT:R-BTA-3159253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAB adenosylates cob(I)alamin (Bos taurus)
REACT:R-DRE-5685994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Long-range resection of DNA DSBs by EXO1 or DNA2 (Danio rerio)
REACT:R-XTR-351871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Z0-2 (Xenopus tropicalis)
REACT:R-BTA-141431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 associates with the Mad1 kinetochore complex (Bos taurus)
REACT:R-GGA-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
REACT:R-XTR-76373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxylation of 4-aminobiphenyl (Xenopus tropicalis)
GO:0047964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dependent glyoxylate reductase activity
GO:0047964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate reductase (NAD+) activity
GO:0047964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolate reductase activity
GO:0047964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylic acid reductase activity
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	prostaglandin 9-ketoreductase activity
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonyl reductase (NADPH) activity
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbonyl reductase activity
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nonspecific NADPH-dependent carbonyl reductase activity
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2-dependent carbonyl reductase activity
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde reductase 1
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	xenobiotic ketone reductase activity
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde reductase I activity
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	secondary-alcohol:NADP+ oxidoreductase activity
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent carbonyl reductase activity
GO:0004090	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ALR3
RHEA:66947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C
RHEA:43124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine
RHEA:43124	skos:prefLabel	"tRNA (guanine(10)-N(2))-dimethyltransferase"
RHEA:43124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (guanine(10)-N(2))-dimethyltransferase"
RHEA:43124	skos:altLabel	"N(2),N(2)-dimethylguanosine tRNA methyltransferase"
RHEA:69746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-benzylsuccinate + succinyl-CoA <=> (S)-2-benzylsuccinyl-CoA + succinate
REACT:R-CFA-8855915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Canis familiaris)
REACT:R-SPO-4615873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates SUZ12 with SUMO1 (Schizosaccharomyces pombe)
REACT:R-XTR-9024997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Xenopus tropicalis)
REACT:R-DDI-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Dictyostelium discoideum)
REACT:R-BTA-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Bos taurus)
REACT:R-GGA-5687101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 phosphorylates FOXO3 (Gallus gallus)
RHEA:17248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 <=> 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2
REACT:R-MMU-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Mus musculus)
RHEA:44263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA
REACT:R-BTA-5683986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APBB1 and MAPK8 bind diphosphorylated H2AFX (Bos taurus)
REACT:R-MMU-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Mus musculus)
REACT:R-GGA-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Gallus gallus)
REACT:R-GGA-2029452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to phosphorylated ITAMs (Gallus gallus)
RHEA:46226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + CoA + H(+) => (E)-feruloyl-CoA + H2O
REACT:R-SCE-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Saccharomyces cerevisiae)
REACT:R-XTR-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Xenopus tropicalis)
RHEA:51458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-isoleucine => H2O + N-(9Z-octadecenoyl)-L-isoleucine
RHEA:33297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:25181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + putrescine = CoA + H(+) + N-acetylputrescine
REACT:R-DRE-2395992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,4S-IRF3 is dimerized (Danio rerio)
RHEA:61534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-2060328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS1 (Canis familiaris)
REACT:R-SSC-8964317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Sus scrofa)
REACT:R-GGA-351987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A6-mediated uptake of taurine and beta-alanine (Gallus gallus)
GO:0005168	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin TRKA receptor ligand
GO:0005168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotrophin TRKA receptor binding
REACT:R-MMU-266299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds membrane-associated free cholesterol and phospholipids (Mus musculus)
REACT:R-DRE-420977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca permeable AMPA receptor ligand binding (Danio rerio)
REACT:R-GGA-5610722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI3 (Gallus gallus)
GO:0035718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrophage migration inhibitory factor binding
GO:0035718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIF binding
RHEA:15257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allothreonine = acetaldehyde + glycine
RHEA:15257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threonine = acetaldehyde + glycine
RHEA:15257	skos:altLabel	"low specificity D-threonine aldolase"
RHEA:15257	skos:altLabel	"DTA"
RHEA:15257	skos:prefLabel	"D-threonine aldolase"
RHEA:15257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-threonine aldolase"
REACT:R-SSC-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Sus scrofa)
GO:0052631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid delta-8 desaturase activity
GO:0019154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolate oxidoreductase activity
GO:0019154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolate:acceptor 2-oxidoreductase activity
GO:0019154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolic acid dehydrogenase activity
GO:0019154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate dehydrogenase activity
GO:0019154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolate:(acceptor) 2-oxidoreductase activity
RHEA:53744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)
REACT:R-DRE-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Danio rerio)
REACT:R-RNO-2187388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Rattus norvegicus)
RHEA:45267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate(out) <=> (9Z,12Z)-octadecadienoate(in)
GO:0046555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylxylan esterase activity
REACT:R-RNO-5684081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds CDK2 and RBBP8 (Rattus norvegicus)
REACT:R-DME-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Drosophila melanogaster)
REACT:R-SSC-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Sus scrofa)
GO:0010178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAA-amino acid conjugate hydrolase activity
REACT:R-DDI-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Dictyostelium discoideum)
RHEA:60363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + H(+) + oxidized coenzyme F420-0 <=> dehydro coenzyme F420-0 + FMNH2
REACT:R-SPO-198640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 (mTOR) phosphorylates AKT at S473 (Schizosaccharomyces pombe)
RHEA:13752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + AMP <=> a ribonucleoside 5'-diphosphate + ADP
RHEA:51129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + an aliphatic amine + H2O => AH2 + an aldehyde + NH4(+)
RHEA:34217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH => 4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+)
REACT:R-XTR-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Xenopus tropicalis)
REACT:R-MMU-213406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from LAT (Mus musculus)
RHEA:31217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH => (5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+)
REACT:R-CFA-6801762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A oligomerize to form a pore complex (Canis familiaris)
REACT:R-BTA-2314686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS2 (Bos taurus)
REACT:R-RNO-9709883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB scavenges O2.- (Rattus norvegicus)
RHEA:40000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid 1-phosphate => a fatty aldehyde + phosphoethanolamine
RHEA:34270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + fumigaclavine B <=> CoA + fumigaclavine A
RHEA:61554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Homo sapiens)
REACT:R-DME-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Drosophila melanogaster)
REACT:R-HSA-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)
REACT:R-HSA-445076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Y1229 in L1 (Homo sapiens)
RHEA:10725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-6-deoxy-alpha-D-talose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
RHEA:62547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin <=> dihydroouabagenin + 2 Fe(III)-[cytochrome c]
RHEA:65840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in) + phosphate(out)
RHEA:41333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate
REACT:R-RNO-9706308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRB10 (Rattus norvegicus)
REACT:R-HSA-6803391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the PCBP4 gene (Homo sapiens)
RHEA:65490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3',3'-c-tri-AMP + 3 diphosphate => 3 ATP
REACT:R-RNO-448660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL31:IL31RA:JAK1 binds OSMR:JAK1 (Rattus norvegicus)
REACT:R-XTR-5668414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Xenopus tropicalis)
REACT:R-HSA-4549334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective DPAGT1 does not transfer GlcNAc to DOLP (Homo sapiens)
REACT:R-SSC-8857928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIHBP1 binds HSPG:LPL dimer (Sus scrofa)
REACT:R-SPO-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Schizosaccharomyces pombe)
REACT:R-DRE-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Danio rerio)
RHEA:53964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin = gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]
RHEA:53964	skos:prefLabel	"ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase"
RHEA:53964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase"
RHEA:13897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chorismate mutase"
RHEA:13897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate = prephenate
RHEA:13897	skos:altLabel	"hydroxyphenylpyruvate synthase"
RHEA:13897	skos:prefLabel	"chorismate mutase"
RHEA:21611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoliquiritigenin + S-adenosyl-L-methionine <=> 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine
GO:0031799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 metabotropic glutamate receptor binding
GO:0031799	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 metabotropic glutamate receptor ligand
RHEA:32944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
REACT:R-PFA-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Plasmodium falciparum)
RHEA:41597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH => (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)
REACT:R-MMU-9641089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin binds Ub:UBE2N:UBE2V1 (Mus musculus)
REACT:R-GGA-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Gallus gallus)
RHEA:11861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidyl-[protein] => ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]
REACT:R-DME-6799981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 binds bacterial peptidoglycan (Drosophila melanogaster)
RHEA:64130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + octadecanoate => H2O + N-octadecanoyl-L-phenylalanine
REACT:R-CEL-2176475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)
RHEA:70650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(out) + H(+)(out) <=> D-serine(in) + H(+)(in)
RHEA:11133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + NADP(+) => H(+) + NADPH + protochlorophyllide a
REACT:R-HSA-2022379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Homo sapiens)
REACT:R-HSA-9708408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid (Homo sapiens)
REACT:R-XTR-76453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A6 (Xenopus tropicalis)
REACT:R-SSC-5357845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is deubiquitinated (Sus scrofa)
REACT:R-SCE-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Saccharomyces cerevisiae)
RHEA:67989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-glutamine => N-acetyl-D-glutamine
REACT:R-HSA-9038161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Homo sapiens)
GO:1990838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends
REACT:R-HSA-8950518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Homo sapiens)
RHEA:64434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanyl-L-prolylglycine(in) => H(+)(out) + L-alanyl-L-prolylglycine(out)
REACT:R-HSA-391942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP receptor can bind prostacyclin (Homo sapiens)
RHEA:23657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate => 3-carboxy-cis,cis-muconate + H(+)
REACT:R-SPO-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Schizosaccharomyces pombe)
RHEA:42366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 2-acyl-sn-glycero-3-phosphocholine
RHEA:63355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-877187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates loss of intracellular K+ (Mus musculus)
RHEA:34784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3alpha-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH
GO:1901618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organic hydroxy compound transmembrane transporter activity
RHEA:16261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]
REACT:R-HSA-8956031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Homo sapiens)
RHEA:66566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-histaminyl-L-glutamyl-[protein] + NH4(+) => histamine + L-glutaminyl-[protein]
REACT:R-MMU-5686286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Mus musculus)
REACT:R-XTR-5684052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates MDC1 (Xenopus tropicalis)
REACT:R-XTR-201472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Xenopus tropicalis)
RHEA:48031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triacetin <=> acetate + diacetylglycerol + H(+)
RHEA:60857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine
REACT:R-SCE-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Saccharomyces cerevisiae)
REACT:R-DRE-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Danio rerio)
REACT:R-HSA-2730900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to pUb-TRAF6 (Homo sapiens)
REACT:R-BTA-5687484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Bos taurus)
REACT:R-DDI-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)
REACT:R-RNO-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Rattus norvegicus)
REACT:R-HSA-8878914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Homo sapiens)
RHEA:38970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine(in) + ATP + H2O <=> ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate
RHEA:42757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Canis familiaris)
RHEA:59195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + eicosanoate + H(+) <=> diphosphate + icosanoyl-AMP
REACT:R-HSA-9727922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3 (Homo sapiens)
REACT:R-RNO-9011952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Rattus norvegicus)
RHEA:49466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + resorcinol => 2,6-dihydroxybenzoate + H(+)
RHEA:43515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(dihydroxymethyl)-5-formylfuran + O2 <=> 2-carboxy-5-formylfuran + H(+) + H2O2
REACT:R-DRE-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)
REACT:R-SSC-432121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL binds to LRP8 (Sus scrofa)
REACT:R-XTR-211968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2W1 oxidises INDOL (Xenopus tropicalis)
RHEA:21644	skos:prefLabel	"glycerol kinase"
RHEA:21644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate
RHEA:21644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol kinase"
RHEA:21644	skos:altLabel	"glycerokinase"
REACT:R-CEL-9617996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Caenorhabditis elegans)
REACT:R-GGA-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Gallus gallus)
RHEA:23438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O
REACT:R-BTA-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Bos taurus)
RHEA:24352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-3-hydroxyacid-ester dehydrogenase"
RHEA:24352	skos:prefLabel	"(R)-3-hydroxyacid-ester dehydrogenase"
RHEA:24352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH
RHEA:24352	skos:altLabel	"3-oxo ester (R)-reductase"
REACT:R-RNO-71275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + glycine => ornithine + guanidoacetate (Rattus norvegicus)
REACT:R-SCE-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)
RHEA:41982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-pregnane-3,20-dione + H(+) + NADH => 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+)
RHEA:52641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA
REACT:R-SPO-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Schizosaccharomyces pombe)
RHEA:41847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-[ACP] <=> (2E)-octenoyl-[ACP] + H2O
RHEA:10000	skos:altLabel	"valeramidase"
RHEA:10000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pentanamide = NH4(+) + pentanoate
RHEA:10000	skos:prefLabel	"pentanamidase"
RHEA:10000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pentanamidase"
REACT:R-HSA-5610737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)
RHEA:59771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-MMU-2395876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
REACT:R-SCE-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Saccharomyces cerevisiae)
REACT:R-SPO-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Schizosaccharomyces pombe)
REACT:R-BTA-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Bos taurus)
REACT:R-HSA-5686440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
REACT:R-XTR-417908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY1 binds ADP (Xenopus tropicalis)
REACT:R-DME-390035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPO dimer autophosphorylates (Drosophila melanogaster)
REACT:R-XTR-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Xenopus tropicalis)
RHEA:67675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate
REACT:R-MMU-429571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Mus musculus)
REACT:R-CEL-3451153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits TRRAP/KAT5 HAT components (Caenorhabditis elegans)
REACT:R-CEL-71130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Caenorhabditis elegans)
REACT:R-DRE-8857662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Danio rerio)
GO:0043719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity
RHEA:23707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + 4 H2O <=> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate
GO:0061603	skos:prefLabel	"molybdenum cofactor guanylyltransferase"
GO:0061603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide
GO:0061603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdenum cofactor guanylyltransferase activity
GO:0061603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"molybdenum cofactor guanylyltransferase"
GO:0061603	skos:altLabel	"MoCo guanylyltransferase"
RHEA:27816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(out) + Na(+)(out) => acetate(in) + Na(+)(in)
REACT:R-BTA-429992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARN deadenylates mRNA (Bos taurus)
RHEA:48246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GM1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1
REACT:R-XTR-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Xenopus tropicalis)
RHEA:66421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)
RHEA:40773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside F1 + D-glucose => (20S)-ginsenoside Rg1 + H2O
REACT:R-DRE-5661517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC comlex binds OTULIN (Danio rerio)
RHEA:68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isatin + NADPH <=> 3-hydroxyindolin-2-one + NADP(+)
RHEA:70649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(in) + H(+)(in) => D-serine(out) + H(+)(out)
GO:0140762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose dehydrogenase (FAD, quinone) activity
REACT:R-BTA-5638012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D dissociates from ARL13B:INPP5E (Bos taurus)
REACT:R-BTA-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Bos taurus)
RHEA:14123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine
REACT:R-MMU-1295613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds GRB2 (Mus musculus)
REACT:R-BTA-9024983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Bos taurus)
REACT:R-DRE-8950269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Danio rerio)
REACT:R-XTR-2029268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of PLCG (Xenopus tropicalis)
RHEA:58335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-en-1-ol + NADP(+) <=> (E)-non-2-enal + H(+) + NADPH
REACT:R-SSC-2428926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Sus scrofa)
RHEA:12525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate + NADP(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADPH
REACT:R-DRE-8848606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates PXN (Danio rerio)
RHEA:28907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) = 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)
RHEA:33403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonine = diphosphate + L-threonyl-5'-AMP
RHEA:10361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydrocoumarin + H2O => 3-(2-hydroxyphenyl)propanoate + H(+)
RHEA:69470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose
RHEA:46401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]
REACT:R-MMU-1614654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Mus musculus)
REACT:R-SSC-5432852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR4:LY96 (Sus scrofa)
REACT:R-DME-110463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Increased PIP3 levels recruit DAkt1 to the membrane (Drosophila melanogaster)
REACT:R-HSA-5658435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs bind RAS:GTP (Homo sapiens)
REACT:R-GGA-202443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of CARMA1 (Gallus gallus)
RHEA:44296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA = 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA
RHEA:13373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-mimosine = 3-hydroxy-4H-pyrid-4-one + L-serine
RHEA:13373	skos:altLabel	"mimosine amidohydrolase"
RHEA:13373	skos:prefLabel	"mimosinase"
RHEA:13373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mimosinase"
GO:0047344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-1-phosphate guanylyltransferase activity
GO:0047344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-glucose pyrophosphorylase activity
GO:0047344	skos:prefLabel	"glucose-1-phosphate guanylyltransferase"
GO:0047344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-glucose diphosphorylase activity
GO:0047344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphoglucose pyrophosphorylase activity
GO:0047344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity
GO:0047344	skos:altLabel	"GDP-glucose pyrophosphorylase"
GO:0047344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-1-phosphate guanylyltransferase"
GO:0047344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:glucose-1-phosphate guanylyltransferase activity
GO:0047344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glucose
GO:0047344	skos:altLabel	"GDP-glucose diphosphorylase"
GO:0047344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP glucose pyrophosphorylase activity
RHEA:30045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iminosuccinate + succinate => fumarate + L-aspartate
GO:0042937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tripeptide transporter activity
GO:0042937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tripeptide transmembrane transporter activity
REACT:R-CFA-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Canis familiaris)
RHEA:22701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Bos taurus)
REACT:R-MMU-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Mus musculus)
RHEA:55312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-RNO-5668718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)
REACT:R-SSC-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Sus scrofa)
EC:1.16.1.-	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
EC:1.16.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
RHEA:11468	skos:altLabel	"valine--3-methyl-2-oxovalerate aminotransferase"
RHEA:11468	skos:altLabel	"valine--isoleucine transaminase"
RHEA:11468	skos:prefLabel	"valine--3-methyl-2-oxovalerate transaminase"
RHEA:11468	skos:altLabel	"valine--isoleucine aminotransferase"
RHEA:11468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine
RHEA:11468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valine--3-methyl-2-oxovalerate transaminase"
REACT:R-MMU-446077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP230 interacts with keretin K5/K14 (Mus musculus)
GO:0005102	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	receptor ligand
GO:0005102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling receptor binding
GO:0005102	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	receptor binding
GO:0005102	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	receptor-associated protein activity
REACT:R-HSA-1266684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7 binds HGF(495-728) to form PPBSF (Homo sapiens)
REACT:R-SSC-9026894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK2 (Sus scrofa)
REACT:R-SPO-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Schizosaccharomyces pombe)
RHEA:38985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-MMU-199935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates CREB (Mus musculus)
RHEA:25961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoin + NADP(+) => benzil + H(+) + NADPH
REACT:R-MMU-6805640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates KAT6A (Mus musculus)
REACT:R-SSC-1237045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Sus scrofa)
REACT:R-CFA-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Canis familiaris)
RHEA:42116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH
RHEA:54221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-all-trans-1,2-dihydro-neurosporene => all-trans-neurosporene + H2O
REACT:R-BTA-5654651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS3 (Bos taurus)
RHEA:37054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
EC:3.4.22.2	skos:prefLabel	"papain"
EC:3.4.22.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"papain"
EC:3.4.22.2	skos:altLabel	"Papaya peptidase I"
GO:0102831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stachyose synthase activity
RHEA:10602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D2 => prostaglandin H2
RHEA:72557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(in) + propanoate(out) => estrone 3-sulfate(out) + propanoate(in)
RHEA:45430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:40682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:52247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 Mn(2+) + O2 <=> 2 H2O + 4 Mn(3+)
REACT:R-RNO-1433506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APS (Rattus norvegicus)
RHEA:32912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphocholine(out) => sn-glycerol 3-phosphocholine(in)
RHEA:45596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
RHEA:53349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20a) in tRNA + NAD(+) => H(+) + NADH + uridine(20a) in tRNA
RHEA:17918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Glu(-Cys)](n)-Gly + glutathione + H(+) => [Glu(-Cys)](n+1)-Gly + glycine
REACT:R-CEL-71010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUT isomerises L-MM-CoA to SUCC-CoA (Caenorhabditis elegans)
REACT:R-XTR-199219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Xenopus tropicalis)
REACT:R-BTA-8987141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Bos taurus)
REACT:R-HSA-5686430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81 binds EME1, EME2 (Homo sapiens)
RHEA:71560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-N(alpha)-glycyl-dTMP in DNA + A + H2O => 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate
RHEA:34306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine <=> L-pipecolate + NH4(+)
REACT:R-BTA-9706287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to ABL2 (Bos taurus)
REACT:R-HSA-8936007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLDN5 (Claudin-5) gene expression is stimulated by RUNX1 (Homo sapiens)
RHEA:26329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine--8-amino-7-oxononanoate transaminase"
RHEA:26329	skos:altLabel	"DAPA aminotransferase"
RHEA:26329	skos:prefLabel	"lysine--8-amino-7-oxononanoate transaminase"
RHEA:26329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + L-lysine = (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate
RHEA:37734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-HSA-2426144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the MVD promoter (Homo sapiens)
REACT:R-MMU-9615348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR2 (Mus musculus)
REACT:R-CEL-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Caenorhabditis elegans)
REACT:R-XTR-140686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Xenopus tropicalis)
REACT:R-CFA-8866553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)
REACT:R-HSA-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Homo sapiens)
RHEA:25603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)ethylmalate + CoA + H(+) => 4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O
RHEA:48540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)
REACT:R-GGA-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Gallus gallus)
RHEA:30630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH
REACT:R-GGA-1022129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)
RHEA:66493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
RHEA:12535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + methyl-coenzyme M <=> coenzyme M-coenzyme B heterodisulfide + methane
RHEA:53269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose => L-xylulose
REACT:R-CFA-379464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DOPAC to form HVA (Canis familiaris)
RHEA:33429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacillithiol + H2O => (S)-malyl alpha-D-glucosaminide + L-cysteine
RHEA:54392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:39612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)
RHEA:58413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] => H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]
RHEA:33140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(out) + L-aspartate(in) => L-alanine(in) + L-aspartate(out)
REACT:R-XTR-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Xenopus tropicalis)
RHEA:64940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGDP + H2O = dGMP + H(+) + phosphate
REACT:R-SPO-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Schizosaccharomyces pombe)
GO:0103031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Ala-D/L-Glu epimerase activity
REACT:R-DRE-4332236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL neddylates TGFBR2 (Danio rerio)
RHEA:65837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate
RHEA:48559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate
RHEA:48664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-dihydrocarminomycin + H(+) + NADPH + O2 => carminomycin + 2 H2O + NADP(+)
REACT:R-HSA-6781899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds SIAH2 (Homo sapiens)
REACT:R-HSA-76397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)
GO:0003884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-amino-acid:oxygen oxidoreductase (deaminating)
GO:0003884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-amino acid:O2 oxidoreductase activity
GO:0003884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-amino-acid oxidase activity
GO:0003884	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	new yellow enzyme
REACT:R-MMU-8849032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS2 (Mus musculus)
RHEA:56500	skos:prefLabel	"bisphosphomevalonate decarboxylase"
RHEA:56500	skos:altLabel	"mevalonate 3,5-bisphosphate decarboxylase"
RHEA:56500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3,5-bisphosphomevalonate + H(+) = CO2 + isopentenyl phosphate + phosphate
RHEA:56500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bisphosphomevalonate decarboxylase"
RHEA:43141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(26) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine
REACT:R-HSA-9662781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD163 gene produces CD163 protein (Homo sapiens)
RHEA:16802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] => adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]
RHEA:25890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + phosphate + quinolinate => dihydroxyacetone phosphate + iminosuccinate
RHEA:58020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = eupatolide + H2O
RHEA:35124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-D-glutamate(out) => H(+)(in) + L-alanyl-D-glutamate(in)
EC:1.23.1.-	skos:prefLabel	"With NADH or NADPH as donor"
EC:1.23.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NADH or NADPH as donor"
REACT:R-MMU-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Mus musculus)
REACT:R-MMU-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Mus musculus)
REACT:R-DRE-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Danio rerio)
REACT:R-SSC-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Sus scrofa)
REACT:R-HSA-3656523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)
RHEA:16964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epsilon-(gamma-L-glutamyl)-L-lysine <=> 5-oxo-L-proline + L-lysine
RHEA:20144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-alkyl-L-cysteine S-oxide <=> 2-aminoprop-2-enoate + an S-alkyl sulfenate
REACT:R-HSA-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Homo sapiens)
RHEA:57891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + 5 H(+)(in) + NADH <=> a quinol + 4 H(+)(out) + NAD(+)
REACT:R-CFA-1675473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B binds JAK2 (Canis familiaris)
RHEA:43402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP => N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose
REACT:R-CFA-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
REACT:R-XTR-112271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex dissociates (Xenopus tropicalis)
REACT:R-SCE-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Saccharomyces cerevisiae)
RHEA:64630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + octyl acetate => acetyl-CoA + octan-1-ol
REACT:R-RNO-8959719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPK phosphorylates Sedo to Sedo7P (Rattus norvegicus)
REACT:R-RNO-5357831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD is phosphorylated by IKK (Rattus norvegicus)
REACT:R-DRE-933533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of p-IRF7 (Danio rerio)
REACT:R-XTR-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Xenopus tropicalis)
REACT:R-RNO-5665998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 binds SRF (Rattus norvegicus)
RHEA:45030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein] => (2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-CFA-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Canis familiaris)
REACT:R-MMU-9015379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (compounds) binds IIa (Mus musculus)
REACT:R-RNO-8987120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IFNLR1 (Rattus norvegicus)
RHEA:34765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate(in) + succinate(out) => (S,S)-tartrate(out) + succinate(in)
REACT:R-GGA-5624132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Gallus gallus)
RHEA:37153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate
REACT:R-SSC-203662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Sus scrofa)
GO:0033972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PAH
GO:0033972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proclavaminate amidinohydrolase activity
GO:0033972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proclavaminic acid amidino hydrolase activity
GO:0033972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proclavaminate amidino hydrolase activity
RHEA:18553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"meso-tartrate dehydrogenase"
RHEA:18553	skos:prefLabel	"meso-tartrate dehydrogenase"
RHEA:18553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH
GO:0033440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine tRNA
GO:0033440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACG codon-amino acid adaptor activity
RHEA:54000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
RHEA:33120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-sativene + diphosphate
EC:3.4.23.38	skos:altLabel	"PfAPG"
EC:3.4.23.38	skos:prefLabel	"plasmepsin I"
EC:3.4.23.38	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plasmepsin I"
EC:3.4.23.38	skos:altLabel	"aspartic hemoglobinase I"
REACT:R-SSC-264871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin B1 (Sus scrofa)
RHEA:53717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP => phosphate + UDP-N-acetyl-alpha-D-muramate
GO:0003974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP acetylglucosamine epimerase activity
GO:0003974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine
GO:0003974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine 4-epimerase"
GO:0003974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate N-acetylglucosamine-4-epimerase activity
GO:0003974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity
GO:0003974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc 4-epimerase activity
GO:0003974	skos:altLabel	"UDP-GlcNAc 4-epimerase"
GO:0003974	skos:prefLabel	"UDP-N-acetylglucosamine 4-epimerase"
GO:0003974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine epimerase activity
GO:0003974	skos:altLabel	"uridine diphosphoacetylglucosamine epimerase"
GO:0003974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine 4-epimerase activity
GO:0003974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine 4-epimerase activity
RHEA:67045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + asnovolin H => AH2 + chermesin D
REACT:R-XTR-2395340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxyallysine by LOX (Xenopus tropicalis)
REACT:R-BTA-1861621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIA with IgG-coated Ag (Bos taurus)
REACT:R-SSC-6810724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3 binds the bacterial surface (Sus scrofa)
REACT:R-GGA-400143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fatty acid ligands activate PPARA (Gallus gallus)
RHEA:64101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + TAN-1612
RHEA:23442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + chloride + H(+) => 4-chlorobenzoate + H2O
EC:2.7.11.18	skos:altLabel	"calcium/calmodulin-dependent myosin light chain kinase"
EC:2.7.11.18	skos:altLabel	"[myosin-light-chain] kinase"
EC:2.7.11.18	skos:altLabel	"MLCK"
EC:2.7.11.18	skos:altLabel	"myosin light-chain kinase"
EC:2.7.11.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[myosin light-chain] kinase"
EC:2.7.11.18	skos:altLabel	"MLCkase"
EC:2.7.11.18	skos:prefLabel	"[myosin light-chain] kinase"
EC:2.7.11.18	skos:altLabel	"myosin light chain protein kinase"
EC:2.7.11.18	skos:altLabel	"smooth-muscle-myosin-light-chain kinase"
EC:2.7.11.18	skos:altLabel	"myosin kinase"
EC:2.7.11.18	skos:altLabel	"myosin light-chain kinase (phosphorylating)"
EC:2.7.11.18	skos:altLabel	"myosin light chain kinase"
GO:0017154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	semaphorin receptor activity
REACT:R-PFA-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Plasmodium falciparum)
REACT:R-BTA-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Bos taurus)
RHEA:18086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + methanophenazine => coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine
REACT:R-SSC-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)
RHEA:67830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid A disaccharide + H(+) + UDP => a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine
RHEA:33309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein] => (2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein]
RHEA:58593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)
RHEA:25187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloroethanol + chloride + H(+) => 1,2-dichloroethane + H2O
RHEA:27446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + xylitol => D-xylose + H(+) + NADPH
REACT:R-HSA-5654222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PLCG1 (Homo sapiens)
RHEA:17823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-cyano-L-alanine + H(+) + hydrogen sulfide => hydrogen cyanide + L-cysteine
REACT:R-DRE-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Danio rerio)
REACT:R-SPO-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Schizosaccharomyces pombe)
REACT:R-HSA-2671872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 (Homo sapiens)
REACT:R-BTA-9009485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34:CSF1 binds CSF1R (Bos taurus)
RHEA:48557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate
REACT:R-SPO-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Schizosaccharomyces pombe)
REACT:R-CFA-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Canis familiaris)
GO:0019702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type IV protein arginine methyltransferase activity
GO:0019702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein arginine N5-methylase activity
GO:0019702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine N5-methyltransferase activity
GO:0019702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine delta-N-methyltransferase activity
GO:0019702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein arginine N5-methyltransferase activity
GO:0019702	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)
GO:0019702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type IV PRMT activity
GO:0015195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine permease activity
GO:0015195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine/serine:sodium symporter activity
GO:0015195	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-threonine transporter activity
GO:0015195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine transmembrane transporter activity
REACT:R-DME-3266557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I cleaves iC3b (Drosophila melanogaster)
REACT:R-GGA-500717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GRIK3 homomer (Gallus gallus)
RHEA:71521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(in) => uridine(out)
EC:1.18.1.4	skos:altLabel	"NAD(P)H-rubredoxin oxidoreductase"
EC:1.18.1.4	skos:altLabel	"rubredoxin-nicotinamide adenine"
EC:1.18.1.4	skos:altLabel	"rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase"
EC:1.18.1.4	skos:prefLabel	"rubredoxin--NAD(P)(+) reductase"
EC:1.18.1.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rubredoxin--NAD(P)(+) reductase"
EC:1.18.1.4	skos:altLabel	"dinucleotide phosphate reductase"
EC:1.18.1.4	skos:altLabel	"NAD(P)-rubredoxin oxidoreductase"
RHEA:40233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-SSC-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Sus scrofa)
REACT:R-CEL-141348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAO:FAD oxidises NASPM to PTCN (Caenorhabditis elegans)
REACT:R-SSC-977317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Sus scrofa)
REACT:R-HSA-5661198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)
REACT:R-MMU-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Mus musculus)
REACT:R-XTR-6785165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Xenopus tropicalis)
REACT:R-RNO-2176491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L binds phosphorylated linker region of SMAD2/3 (Rattus norvegicus)
RHEA:63983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-thiouridine + ATP <=> 4-thiouridine 5'-phosphate + ADP + H(+)
RHEA:44569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) => 2-all-trans-hexaprenylphenol + CO2
GO:0102223	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	4,4'-diapophytoene desaturase activity
GO:0102223	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	4,4'-diapo-zeta-carotene desaturase activity
GO:0102223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming)
GO:0102223	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	4,4'-diapophytofluene desaturase activity
GO:0102223	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	4,4'-diaponeurosporene desaturase activity
REACT:R-MMU-389756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT interacts and phosphorylates Cot (Mus musculus)
RHEA:31278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (S)-methylmalonate semialdehyde + H(+) + NADH
REACT:R-RNO-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Rattus norvegicus)
REACT:R-HSA-5250607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botD HC:LC binds SV2A or B or C and GD2 on the target cell surface (Homo sapiens)
REACT:R-BTA-9648268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A antagonists (Bos taurus)
REACT:R-DRE-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Danio rerio)
REACT:R-BTA-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Bos taurus)
GO:0044717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxy-dADP phosphatase activity
GO:0044717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)
RHEA:10956	skos:altLabel	"cinnamic acid 2-hydroxylase"
RHEA:10956	skos:altLabel	"cinnamic 2-hydroxylase"
RHEA:10956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) + NADPH + O2 = H2O + NADP(+) + trans-2-coumarate
RHEA:10956	skos:prefLabel	"trans-cinnamate 2-monooxygenase"
RHEA:10956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-cinnamate 2-monooxygenase"
GO:0016892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoribonuclease activity, producing other than 5'-phosphomonoesters
GO:0016892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Endoribonucleases producing other than 5'-phosphomonoesters"
GO:0016892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoribonuclease activity, producing 3'-phosphomonoesters
GO:0016892	skos:prefLabel	"Endoribonucleases producing other than 5'-phosphomonoesters"
RHEA:71858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurochenodeoxycholate(out) <=> taurochenodeoxycholate(in)
RHEA:68310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O
RHEA:57446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O
REACT:R-HSA-6809309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR6 binds MTMR9 (Homo sapiens)
REACT:R-HSA-6814418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes formation of G-beta:G-gamma heterodimers (Homo sapiens)
RHEA:43262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O
RHEA:36994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + UMP <=> alpha-D-ribose 1,5-bisphosphate + uracil
REACT:R-BTA-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Bos taurus)
RHEA:31490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose <=> H(+) + soyasaponin III + UDP
EC:4.1.1.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminobenzoate decarboxylase"
EC:4.1.1.24	skos:altLabel	"aminobenzoate carboxy-lyase"
EC:4.1.1.24	skos:prefLabel	"aminobenzoate decarboxylase"
REACT:R-DRE-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Danio rerio)
REACT:R-HSA-9708457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HM13 cleaves HMOX1 dimer (Homo sapiens)
RHEA:36382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4alpha-methylzymosterol + H(+) + NADPH <=> 4alpha-methylzymosterol + NADP(+)
REACT:R-BTA-3371360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)
REACT:R-CFA-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Canis familiaris)
GO:0036009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glutamine N-methyltransferase activity
GO:0036009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Homo sapiens)
GO:0036009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein glutamine N-methyltransferase activity
GO:0036009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein glutamine N-methylase activity
GO:0047387	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SEP diesterase activity
GO:0047387	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine-phosphoethanolamine ethanolaminephosphohydrolase activity
GO:0047387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-ethanolaminephosphate phosphodiesterase activity
GO:0047387	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine ethanolamine phosphodiester phosphodiesterase activity
REACT:R-RNO-8877760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Rattus norvegicus)
REACT:R-DRE-201486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand pleiotrophin (PTN) (Danio rerio)
GO:0030021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core matrisome
GO:0030021	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core extracellular matrix
GO:0030021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular matrix structural constituent conferring compression resistance
RHEA:63416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dichlorohydroquinone + FADH2 + O2 = 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O
RHEA:22215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate <=> (2R,3S)-tartrate
GO:1990841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	promoter-specific chromatin binding
RHEA:61245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan + O2 => H2O2 + indole-3-pyruvate + NH4(+)
RHEA:24926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine <=> 2-oxobutanoate + NH4(+)
REACT:R-BTA-5618093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP90 (Bos taurus)
RHEA:27417	skos:altLabel	"nicotinic acid hydroxylase"
RHEA:27417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinate dehydrogenase (cytochrome)"
RHEA:27417	skos:altLabel	"nicotinate hydroxylase"
RHEA:27417	skos:prefLabel	"nicotinate dehydrogenase (cytochrome)"
RHEA:27417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome] + H2O + nicotinate = 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)
REACT:R-BTA-8944214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type I (Bos taurus)
RHEA:20117	skos:prefLabel	"rhamnulokinase"
RHEA:20117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-rhamnulose = ADP + H(+) + L-rhamnulose 1-phosphate
RHEA:20117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnulokinase"
RHEA:41937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP
RHEA:19488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP
REACT:R-XTR-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Xenopus tropicalis)
GO:0103026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose-1-phosphatase activity
REACT:R-GGA-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Gallus gallus)
GO:0061578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63-specific deubiquitinase activity
GO:0061578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63-linked deubiquitinase activity
GO:0061578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lys63-specific deubiquitinase activity
RHEA:66425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + leukotriene B4(in) => ADP + H(+) + leukotriene B4(out) + phosphate
RHEA:20639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone + D-sorbitol => D-fructose + D-glucose
RHEA:46422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-BTA-1562640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LNK binds to p-KIT and inhibit downstream signaling (Bos taurus)
REACT:R-CEL-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Caenorhabditis elegans)
REACT:R-SSC-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Sus scrofa)
RHEA:45255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetradecanoate(out) <=> tetradecanoate(in)
RHEA:69926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	castasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-3000112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Danio rerio)
RHEA:40247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + rhodomycin D = 10-carboxy-13-deoxycarminomycin + H(+) + methanol
REACT:R-XTR-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Xenopus tropicalis)
RHEA:70060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Mus musculus)
REACT:R-MMU-417820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 receptor can bind to LPA (Mus musculus)
RHEA:67619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GTP + H2O <=> 8-oxo-GMP + diphosphate + H(+)
REACT:R-BTA-264871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin B1 (Bos taurus)
REACT:R-RNO-2024084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS-GAGs translocate to the lysosome for degradation (Rattus norvegicus)
REACT:R-SSC-444126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Sus scrofa)
RHEA:32934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol <=> a cardiolipin + CMP + H(+)
RHEA:46715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine
GO:0160010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]
GO:0160010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein de-2-hydroxyisobutyrylase activity
REACT:R-DDI-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Dictyostelium discoideum)
REACT:R-RNO-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Rattus norvegicus)
RHEA:52735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)
REACT:R-GGA-174235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdc20 (Gallus gallus)
REACT:R-CEL-517536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Caenorhabditis elegans)
REACT:R-SSC-390912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds hist (Sus scrofa)
REACT:R-HSA-8874205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L2 (Homo sapiens)
REACT:R-GGA-6807134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)
RHEA:21119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose
RHEA:32007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene
REACT:R-SSC-1562640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LNK binds to p-KIT and inhibit downstream signaling (Sus scrofa)
REACT:R-CFA-5336184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37L binds prosaposin (Canis familiaris)
REACT:R-GGA-373889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate + H+ [cytosol] <=> lactate + H+ [extracellular] (Gallus gallus)
RHEA:37004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA
REACT:R-DME-8854052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the SCF-FBXL7 complex (Drosophila melanogaster)
REACT:R-MMU-373714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-Heterodimerization of nephrin and KIRREL (Mus musculus)
RHEA:41735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + phosphate <=> [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
REACT:R-CEL-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Caenorhabditis elegans)
REACT:R-RNO-9796368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 binds STUB1 (Rattus norvegicus)
RHEA:56314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate => 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O
REACT:R-BTA-198315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IRS recruits PI3K to the plasma membrane and activates it (Bos taurus)
REACT:R-DDI-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Dictyostelium discoideum)
REACT:R-CEL-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Caenorhabditis elegans)
RHEA:38160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-hydroxyarginine => (2S,3R)-capreomycidine + H2O
REACT:R-HSA-2028724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind YAP1 (Homo sapiens)
REACT:R-DRE-2395322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyridinoline cross-links (Danio rerio)
RHEA:39414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O
RHEA:52727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate <=> a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)
RHEA:66574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-naphthol + 3'-phosphoadenylyl sulfate
REACT:R-CFA-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Canis familiaris)
GO:0103057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity
RHEA:43641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + CoA
RHEA:63341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-amino acyl-L-seryl-[protein] => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate
REACT:R-HSA-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Homo sapiens)
RHEA:18108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Ca(2+)(in) + H2O <=> ADP + Ca(2+)(out) + H(+) + phosphate
RHEA:69407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil(in) <=> uracil(out)
REACT:R-CFA-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Canis familiaris)
RHEA:18030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + hydrogencarbonate + NH4(+) => 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate
RHEA:19999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + pyruvate => H2O + phosphoenolpyruvate
REACT:R-BTA-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Bos taurus)
RHEA:20729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + O2 => 2-oxoglutarate + H2O2 + NH4(+)
RHEA:49993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + propane => H2O + NAD(+) + propan-2-ol
REACT:R-GGA-997314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of JAK1 by SHP1 (Gallus gallus)
REACT:R-GGA-372697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binding to p130cas (Gallus gallus)
REACT:R-XTR-6785933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT8 transfers Gal from UDP-Gal to CERA (Xenopus tropicalis)
REACT:R-XTR-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)
RHEA:55458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol => ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:24837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate
REACT:R-DRE-168166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B complex is transported from cytosol to nucleus (Danio rerio)
RHEA:65299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:56784	skos:altLabel	"gamma-glutamyl hydrolase"
RHEA:56784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"folate gamma-glutamyl hydrolase"
RHEA:56784	skos:altLabel	"gamma-Glu-X carboxypeptidase"
RHEA:56784	skos:altLabel	"pteroyl-poly-alpha-glutamate hydrolase"
RHEA:56784	skos:altLabel	"tetrahydropteroyl-poly-gamma-glutamyl gamma-glutamyl hydrolase"
RHEA:56784	skos:altLabel	"carboxypeptidase G"
RHEA:56784	skos:prefLabel	"folate gamma-glutamyl hydrolase"
RHEA:56784	skos:altLabel	"conjugase"
RHEA:56784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate
RHEA:56784	skos:altLabel	"lysosomal gamma-glutamyl carboxypeptidase"
RHEA:56784	skos:altLabel	"folate conjugase"
REACT:R-HSA-9703432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from FLT3 fusion proteinsp- (Homo sapiens)
RHEA:42793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + hexadecanoyl-CoA => cholesteryl hexadecanoate + CoA
REACT:R-SCE-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Saccharomyces cerevisiae)
RHEA:32138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Canis familiaris)
REACT:R-DDI-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Dictyostelium discoideum)
REACT:R-CFA-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Canis familiaris)
REACT:R-RNO-9018746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds effectors at the plasma membrane (Rattus norvegicus)
REACT:R-PFA-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Plasmodium falciparum)
REACT:R-RNO-5696183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC3 deaminates BZAM (Rattus norvegicus)
RHEA:60182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-fructose(in) + H(+) + phosphate => ATP + D-fructose(out) + H2O
RHEA:19186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + propanoyl-CoA => 2-hydroxyglutarate + CoA + H(+)
RHEA:61558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:65447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + hexan-1-ol <=> CoA + hexyl butanoate
REACT:R-HSA-912627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates PI3K (Homo sapiens)
RHEA:42739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine
REACT:R-RNO-5635741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Rattus norvegicus)
REACT:R-DME-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Drosophila melanogaster)
RHEA:49611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH
RHEA:65670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine
REACT:R-SSC-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Sus scrofa)
RHEA:45967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O <=> 2 AMP + ATP + 2 H(+)
REACT:R-RNO-6800299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGFAC cleaves pro-HGF to form HGF dimer (Rattus norvegicus)
REACT:R-MMU-9709360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 reduces MetHb (Mus musculus)
REACT:R-BTA-936942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Bos taurus)
REACT:R-CFA-996755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFPM proteins bind GATA proteins (Canis familiaris)
RHEA:57307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP <=> glycolate + GMP + H(+)
RHEA:25230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NADP(+) => H(+) + L-arabinose + NADPH
REACT:R-HSA-3249390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Homo sapiens)
REACT:R-SSC-8983335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Sus scrofa)
REACT:R-DME-1433508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC alpha interacts with and phosphorylates KIT (Drosophila melanogaster)
REACT:R-CFA-9661408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Canis familiaris)
REACT:R-CFA-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Canis familiaris)
REACT:R-RNO-2471621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin degradation by cathepsins (Rattus norvegicus)
RHEA:68305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] => 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)
RHEA:44151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine <=> D-beta-lysine
GO:0033549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP kinase phosphatase activity
GO:0033549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK phosphatase activity
REACT:R-GGA-5654592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)
RHEA:25880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-dopa + O2 = 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)
RHEA:25880	skos:altLabel	"DOPA oxidative deaminase"
RHEA:25880	skos:altLabel	"DOPAODA"
RHEA:25880	skos:altLabel	"oxidative deaminase"
RHEA:25880	skos:prefLabel	"3,4-dihydroxyphenylalanine oxidative deaminase"
RHEA:25880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,4-dihydroxyphenylalanine oxidative deaminase"
REACT:R-BTA-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Bos taurus)
REACT:R-RNO-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Rattus norvegicus)
REACT:R-GGA-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Gallus gallus)
RHEA:11843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H2O + NAD(+) <=> benzoate + 2 H(+) + NADH
REACT:R-XTR-4088130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds FOXM1 (Xenopus tropicalis)
RHEA:44658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-6785361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of FANCD2:FANCI (Rattus norvegicus)
RHEA:47794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine
RHEA:72307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + taurocholate(out) = L-glutamate(out) + taurocholate(in)
RHEA:62476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)
REACT:R-DRE-114548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Danio rerio)
REACT:R-BTA-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Bos taurus)
REACT:R-SSC-8848596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds PXN (Sus scrofa)
RHEA:16165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan 2-monooxygenase"
RHEA:16165	skos:prefLabel	"tryptophan 2-monooxygenase"
RHEA:16165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide
RHEA:24210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-mannitol + NADP(+)
REACT:R-MMU-9706312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to LCK (Mus musculus)
RHEA:64620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + acetyl-CoA = (E)-sinapoyl actetate + CoA
REACT:R-SCE-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Saccharomyces cerevisiae)
REACT:R-SSC-2161950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Sus scrofa)
REACT:R-BTA-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Bos taurus)
REACT:R-DDI-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Dictyostelium discoideum)
REACT:R-CFA-9709317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to free ferrohemoglobin (Canis familiaris)
REACT:R-MMU-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Mus musculus)
REACT:R-CEL-9623384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-agonists bind ADRA1A,B,D (Caenorhabditis elegans)
RHEA:14793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoadipate reductase"
RHEA:14793	skos:altLabel	"alpha-ketoadipate reductase"
RHEA:14793	skos:altLabel	"2-ketoadipate reductase"
RHEA:14793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH
RHEA:14793	skos:prefLabel	"2-oxoadipate reductase"
REACT:R-CEL-5340320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTP transports GSL from plasma membrane to ER membrane (Caenorhabditis elegans)
REACT:R-RNO-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Rattus norvegicus)
GO:1905762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR4-NOT complex binding
REACT:R-BTA-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Bos taurus)
RHEA:11153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-pyridoxate + NADPH + O2 => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)
RHEA:56430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-XTR-5635741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Xenopus tropicalis)
RHEA:25076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
REACT:R-DRE-390846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2D3,4 bind to DA (Danio rerio)
REACT:R-DME-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
EC:3.4.23.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspergillopepsin I"
EC:3.4.23.18	skos:altLabel	"awamorin"
EC:3.4.23.18	skos:altLabel	"aspergillopeptidase A"
EC:3.4.23.18	skos:altLabel	"aspergillopepsin A"
EC:3.4.23.18	skos:altLabel	"proctase B"
EC:3.4.23.18	skos:altLabel	"proteinase B"
EC:3.4.23.18	skos:prefLabel	"aspergillopepsin I"
EC:3.4.23.18	skos:altLabel	"trypsinogen kinase"
EC:3.4.23.18	skos:altLabel	"Protease type XIII"
EC:3.4.23.18	skos:altLabel	"aspergillopepsin F"
RHEA:64818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate(out) => 5-aminolevulinate(in)
REACT:R-BTA-446130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 2 binds Interleukin 1 (Bos taurus)
REACT:R-HSA-1067667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R (Homo sapiens)
GO:0003832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-dopamine hydrolase activity
GO:0003832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBAD hydrolase activity
GO:0003832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-beta-alanyl-dopamine hydrolase activity
REACT:R-RNO-5661124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR4-HIST1H4 (Rattus norvegicus)
RHEA:35216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XDP => H(+) + phosphate + XMP
REACT:R-HSA-445113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Urotensin-2 receptor binds urotensin-2 and 2B (Homo sapiens)
GO:0031749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2 dopamine receptor binding
GO:0031749	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D2 dopamine receptor ligand
REACT:R-XTR-947514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3 (Xenopus tropicalis)
RHEA:65613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:11322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-xylose => UDP-beta-L-arabinopyranose
RHEA:33864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-7 + succinate => fumarate + menaquinol-7
REACT:R-XTR-9750942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
REACT:R-BTA-8851827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Bos taurus)
REACT:R-DME-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Drosophila melanogaster)
RHEA:22647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + protopine + reduced [NADPH--hemoprotein reductase] <=> 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:19107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + 2 H(+) + NADH => 4-aminobutanal + H2O + NAD(+)
RHEA:19207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + dUMP + NH4(+) => dCTP + 2 H2O
RHEA:54985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol => a ubiquinone + 2 e(-) + 2 H(+)
REACT:R-RNO-3149539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Rattus norvegicus)
REACT:R-BTA-1630304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Bos taurus)
RHEA:39007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cholesterol ester(in) = a cholesterol ester(out)
RHEA:71997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + preaspterpenacid acid I => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O
RHEA:51732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glandicoline B + S-adenosyl-L-methionine = H(+) + meleagrin + S-adenosyl-L-homocysteine
REACT:R-HSA-204798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and p85 of PI3K (Homo sapiens)
GO:0061891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium ion sensor activity
REACT:R-HSA-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Homo sapiens)
RHEA:22166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Forssman (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine
RHEA:23931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(8)-acetylspermidine <=> acetate + spermidine
REACT:R-BTA-9013006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP translocates to the ER membrane (Bos taurus)
RHEA:38608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-phospho-cyclic ADP-ribose + nicotinate => nicotinate-adenine dinucleotide phosphate
REACT:R-CFA-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Canis familiaris)
REACT:R-CFA-183130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Canis familiaris)
REACT:R-CEL-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Caenorhabditis elegans)
REACT:R-DME-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Drosophila melanogaster)
REACT:R-HSA-8936068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H19 is cleaved to produce miR-675 (Homo sapiens)
REACT:R-RNO-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Rattus norvegicus)
RHEA:25112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyridoxine 5'-phosphate = phosphate + pyridoxine
RHEA:16200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH
RHEA:66845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] => asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:41390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O
RHEA:27895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-CMP + H2O => cytidine + phosphate
REACT:R-XTR-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Xenopus tropicalis)
REACT:R-XTR-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Xenopus tropicalis)
REACT:R-XTR-9018594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds LBR (Xenopus tropicalis)
RHEA:33423	skos:altLabel	"N,N'-diacetylchitobiose PTS permease"
RHEA:33423	skos:altLabel	"chitobiose PTS permease"
RHEA:33423	skos:prefLabel	"protein-N(pi)-phosphohistidine--N,N'-diacetylchitobiose phosphotransferase"
RHEA:33423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--N,N'-diacetylchitobiose phosphotransferase"
RHEA:33423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) = diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]
REACT:R-RNO-2426566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and CLM7 (Rattus norvegicus)
REACT:R-BTA-2076392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcA to heparan (Bos taurus)
GO:0102240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol B glucuronide galactosyltransferase activity
RHEA:61804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-alanine = diphosphate + L-alanyl-5'-AMP
RHEA:65167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + hexan-3-ol <=> CoA + hexan-3-yl benzoate
RHEA:26381	skos:prefLabel	"succinic semialdehyde reductase"
RHEA:26381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinic semialdehyde reductase"
RHEA:26381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + NADP(+) = H(+) + NADPH + succinate semialdehyde
RHEA:37314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-glutamine(out) + H2O <=> ADP + glycyl-L-glutamine(in) + H(+) + phosphate
REACT:R-MMU-9011981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 is recruited to MYC and BCL2 genes (Mus musculus)
REACT:R-RNO-1474266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibrils (Rattus norvegicus)
REACT:R-XTR-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Xenopus tropicalis)
REACT:R-BTA-9758090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Bos taurus)
RHEA:42687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-hercynylcysteine S-oxide + H2O <=> L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide
RHEA:12933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate
RHEA:12933	skos:altLabel	"L-fuculose-1-phosphate lactaldehyde-lyase"
RHEA:12933	skos:prefLabel	"L-fuculose-phosphate aldolase"
RHEA:12933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-fuculose-phosphate aldolase"
RHEA:12933	skos:altLabel	"fuculose aldolase"
RHEA:12933	skos:altLabel	"L-fuculose 1-phosphate aldolase"
REACT:R-CFA-71588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Canis familiaris)
REACT:R-CFA-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Canis familiaris)
REACT:R-DRE-190265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds to FGF (Danio rerio)
RHEA:53389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP
REACT:R-HSA-9013024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors at the plasma membrane (Homo sapiens)
REACT:R-RNO-5695980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD10 dehydrogenates S-2MPDA-CoA (Rattus norvegicus)
REACT:R-HSA-156808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Homo sapiens)
RHEA:12391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:47304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-GGA-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Gallus gallus)
RHEA:67790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin => 2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol
REACT:R-CFA-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Canis familiaris)
RHEA:43354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol(out) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(in)
RHEA:42947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(40) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Xenopus tropicalis)
EC:4.4.1.28	skos:prefLabel	"L-cysteine desulfidase"
EC:4.4.1.28	skos:altLabel	"L-cysteine desulfhydrase"
EC:4.4.1.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-cysteine desulfidase"
REACT:R-BTA-165162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TSC2 by PKB (Bos taurus)
REACT:R-BTA-5633040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Bos taurus)
RHEA:50560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-terminal methionine N(alpha)-acetyltransferase NatC"
RHEA:50560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]
RHEA:50560	skos:prefLabel	"N-terminal methionine N(alpha)-acetyltransferase NatC"
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrofolate synthase activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FHFS/FPGS activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FHFS activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H2-folate synthetase activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHFS activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydropteroate:L-glutamate ligase (ADP-forming)
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrofolate synthetase activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydropteroate:L-glutamate ligase (ADP-forming) activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydrofolate synthetase activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H(2)-folate synthetase activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydropteroate:L-glutamate ligase (ADP) activity
GO:0008841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrofolate synthetase-folylpolyglutamate synthetase activity
RHEA:21719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O
GO:0042890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropionic acid transmembrane transporter activity
GO:0042890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCA transporter activity
GO:0042890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrocinnamic acid transporter activity
GO:0042890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropionate acid transporter activity
REACT:R-CFA-374248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR3 binds ligands CXCL9 to 11 (Canis familiaris)
RHEA:54893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
RHEA:50906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine => L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine
REACT:R-BTA-429699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 binds ceramide (Bos taurus)
RHEA:65871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(1)-dihydrotestosterone + H2O <=> 1,17beta-dihydroxyandrostan-3-one
REACT:R-HSA-1605724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Homo sapiens)
REACT:R-MMU-9724753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds anti-fibrinolytics (Mus musculus)
REACT:R-XTR-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Xenopus tropicalis)
GO:0015568	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-idonate/D-gluconate:hydrogen symporter activity
GO:0015568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate transmembrane transporter activity
RHEA:38575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)
RHEA:40266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH
REACT:R-SPO-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Schizosaccharomyces pombe)
REACT:R-DRE-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Danio rerio)
RHEA:25247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + glutathione + H(+) => (R)-S-lactoylglutathione + H2O
REACT:R-CFA-3858489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds DAAM1 (Canis familiaris)
REACT:R-CEL-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Caenorhabditis elegans)
GO:0005117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	wishful thinking binding
GO:0005117	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	wishful thinking ligand
GO:0005117	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Wit ligand
GO:0005117	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SE20 receptor binding
GO:0005117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wit binding
RHEA:67685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid(in) + ATP + H2O => a long-chain fatty acid(out) + ADP + H(+) + phosphate
RHEA:51736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-GGA-8952371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds RUNX3 (Gallus gallus)
GO:0050055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	limonoate-D-ring-lactone lactonohydrolase activity
GO:0050055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonin-D-ring-lactonase activity
GO:0050055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	limonin-D-ring-lactone hydrolase activity
GO:0050055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	limonin lactone hydrolase activity
REACT:R-HSA-9694625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp3 cleaves nsp1-4 (Homo sapiens)
REACT:R-DRE-199910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates ATF1 (Danio rerio)
RHEA:11029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-mannose => ADP + D-mannose 6-phosphate + H(+)
REACT:R-CFA-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Canis familiaris)
REACT:R-XTR-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Xenopus tropicalis)
REACT:R-DME-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Drosophila melanogaster)
REACT:R-SSC-215526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F3 20-hydroxylates LTB4 (Sus scrofa)
RHEA:52880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-RNO-9018868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Rattus norvegicus)
RHEA:37918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
RHEA:31518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-apo-beta-carotenal + H2O + NAD(+) <=> 2 H(+) + NADH + neurosporaxanthin
RHEA:21138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-acetyl-(R)-carnitine => (R)-carnitine + acetyl-CoA
REACT:R-BTA-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Bos taurus)
REACT:R-XTR-1592240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NRF2 (Xenopus tropicalis)
REACT:R-CFA-109415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)
GO:0047597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocineole dehydrogenase activity
GO:0047597	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-oxocineole oxygenase activity
GO:0047597	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-oxocineole,NADPH:oxygen oxidoreductase activity
RHEA:51665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-5-phenylhydantoin + H2O => H(+) + N-carbamoyl-D-phenylglycine
REACT:R-MMU-5654428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates SHC1 (Mus musculus)
RHEA:53260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5696230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO1 dimer reduces methylarsonate to methylarsonite (Bos taurus)
REACT:R-BTA-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Bos taurus)
REACT:R-DDI-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Dictyostelium discoideum)
REACT:R-RNO-9700168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates IRS1 (Rattus norvegicus)
RHEA:53287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + scyllo-inosose <=> 3-dehydro-scyllo-inosose + H(+) + NADH
GO:0050362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan:2-oxoglutarate aminotransferase activity
GO:0050362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan aminotransferase activity
GO:0050362	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-tryptophan transaminase activity
GO:0050362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxytryptophan aminotransferase activity
GO:0050362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-hydroxytryptophan-ketoglutaric transaminase activity
GO:0050362	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-tryptophan aminotransferase activity
GO:0050362	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-phenylalanine-2-oxoglutarate aminotransferase activity
GO:0050362	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tryptophan transaminase activity
RHEA:11622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopent-4-enoate + chloride + H(+) + NH4(+) => H2O + L-2-amino-4-chloropent-4-enoate
REACT:R-XTR-6799722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 oxidoreductase generates unstable semiquinones (Xenopus tropicalis)
REACT:R-GGA-8948232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Gallus gallus)
RHEA:24928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cystine => NH4(+) + pyruvate + S-sulfanyl-L-cysteine
REACT:R-HSA-442592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
REACT:R-CEL-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Caenorhabditis elegans)
REACT:R-GGA-4090408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate ESR1 with SUMO1 (Gallus gallus)
REACT:R-MMU-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Mus musculus)
RHEA:69860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in 12S rRNA + S-adenosyl-L-methionine => a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-8948234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB:4-Hyp collagen propeptides dissociates (Danio rerio)
REACT:R-PFA-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Plasmodium falciparum)
REACT:R-CEL-5671772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T38-PPP1R14A binds MLCP (Caenorhabditis elegans)
REACT:R-GGA-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Gallus gallus)
REACT:R-MMU-5674130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)
GO:0052625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pABA amino acid synthetase activity
GO:0052625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-aminobenzoate amino acid synthetase activity
GO:0052625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoyl amino acid synthetase activity
GO:0052625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate amino acid synthetase activity
GO:0052625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-aminobenzoyl amino acid synthetase activity
REACT:R-DRE-166753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C4 into C4a and C4b (Danio rerio)
GO:0102281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formylaminopyrimidine deformylase activity
RHEA:37903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxytryprostatin B + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tryprostatin A
RHEA:37903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-hydroxytryprostatin B O-methyltransferase"
RHEA:37903	skos:prefLabel	"6-hydroxytryprostatin B O-methyltransferase"
REACT:R-XTR-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Xenopus tropicalis)
REACT:R-GGA-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Gallus gallus)
REACT:R-XTR-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Xenopus tropicalis)
RHEA:37483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine = 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)
REACT:R-BTA-8959719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPK phosphorylates Sedo to Sedo7P (Bos taurus)
RHEA:16690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + H2O => D-glucose + phosphate
RHEA:63951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphinga-4E,14Z-dienine-1-phosphate <=> phosphate + sphinga-4E,14Z-dienine
REACT:R-BTA-6786058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL4-bound IL4R1 (Bos taurus)
REACT:R-SCE-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Saccharomyces cerevisiae)
REACT:R-DDI-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Dictyostelium discoideum)
GO:0102560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity
GO:0102560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
REACT:R-CFA-6805022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 binds the heterodimer of MDM2 and MDM4 (Canis familiaris)
RHEA:48622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione
REACT:R-CEL-354173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)
GO:0060228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	LCAT activator activity
GO:0060228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine-sterol O-acyltransferase activator activity
RHEA:36304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)
RHEA:28876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-tyrosine(in) => H(+)(out) + L-tyrosine(out)
REACT:R-SSC-9680865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4, CYP2B6 bind ritonavir (Sus scrofa)
RHEA:56388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
RHEA:43656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)
REACT:R-DRE-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Danio rerio)
REACT:R-DRE-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Danio rerio)
RHEA:58588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate + NADPH = (+)-vincadifformine + acetate + NADP(+)
RHEA:15608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine O-sulfate <=> H(+) + NH4(+) + pyruvate + sulfate
REACT:R-HSA-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Homo sapiens)
RHEA:18385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + 2 ATP + 3 H2O + hydrogencarbonate = acetoacetate + 2 AMP + 4 H(+) + 4 phosphate
GO:0034797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fosfomycin 2-glutathione ligase activity
RHEA:36454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-glutamate(out) + H2O <=> ADP + glycyl-L-glutamate(in) + H(+) + phosphate
REACT:R-MMU-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
REACT:R-DRE-192341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Danio rerio)
REACT:R-SPO-5655835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Schizosaccharomyces pombe)
RHEA:60236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate
RHEA:60236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-trimethyl-L-lysine(36) demethylase"
RHEA:60236	skos:prefLabel	"[histone H3]-trimethyl-L-lysine(36) demethylase"
GO:0140580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitophagy receptor
GO:0140580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrion autophagosome adaptor activity
REACT:R-BTA-445753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Bos taurus)
GO:0055043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxovalerate dehydrogenase activity
REACT:R-SSC-5696007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF3 ligates CoA-SH to VLCFA (Sus scrofa)
RHEA:36471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate(out) + H(+)(out) = 3,4,5-trihydroxybenzoate(in) + H(+)(in)
REACT:R-CFA-9638064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Canis familiaris)
REACT:R-MMU-2870221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-selectin binds E-selectin ligand (Mus musculus)
RHEA:22399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> glycolaldehyde + guaiacol + H2O + vanillin
REACT:R-GGA-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Gallus gallus)
RHEA:71833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + creatine(in) + 2 Na(+)(in) => chloride(out) + creatine(out) + 2 Na(+)(out)
RHEA:46805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine => a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)
RHEA:55874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH => anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+)
REACT:R-CFA-9012268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)
REACT:R-HSA-1297333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Acrosin Heavy and Light Chain (Homo sapiens)
RHEA:55592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (3R)-hydroxydecanoyl-[ACP] + H2O = (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]
RHEA:47986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + hydroxysqualene => H2O + presqualene diphosphate
REACT:R-DRE-376369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp2 associated secretory vesicle to plasma membrane transport (Danio rerio)
GO:0045130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity
GO:0045130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keratan sulphotransferase activity
GO:0045130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl keratan sulfotransferase activity
GO:0045130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keratan sulfate Gal-6-sulfotransferase activity
GO:0045130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keratan sulfotransferase activity
GO:0045130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	keratan sulfate sulfotransferase activity
GO:0045130	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylylsulfate:keratan sulfotransferase activity
GO:0003779	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	membrane associated actin binding
GO:0003779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin binding
REACT:R-HSA-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Homo sapiens)
RHEA:66771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + coproporphyrin I(in) + H2O <=> ADP + coproporphyrin I(out) + H(+) + phosphate
REACT:R-BTA-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Bos taurus)
REACT:R-DME-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Drosophila melanogaster)
REACT:R-DRE-873926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNGR (Danio rerio)
REACT:R-CFA-266012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTD4 is converted to LTE4 by DPEP1/2 (Canis familiaris)
REACT:R-RNO-77254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Rattus norvegicus)
GO:0016230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral sphingomyelinase activator
GO:0016230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingomyelin phosphodiesterase activator activity
RHEA:68578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + xanthine(in) => ATP + H2O + xanthine(out)
REACT:R-MMU-4090408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate ESR1 with SUMO1 (Mus musculus)
RHEA:21025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glyoxylate + NADP(+) => H(+) + NADPH + oxalyl-CoA
RHEA:31757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5,6-dehydrosuberyl-CoA semialdehyde => 2-oxepin-2(3H)-ylideneacetyl-CoA + H2O
REACT:R-XTR-5625416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anterograde IFT (Xenopus tropicalis)
RHEA:34657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine => C30 botryococcene + 2 S-adenosyl-L-methionine
REACT:R-BTA-447252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB1:TYK2 binds IL12RB2:JAK2 (Bos taurus)
RHEA:54495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine
GO:0030380	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-17E receptor ligand
GO:0030380	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-17E
GO:0030380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-17E receptor binding
GO:0008496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-alpha-1->6-D-mannanase activity
GO:0008496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,6-alpha-D-mannan mannanohydrolase activity
GO:0008496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannan endo-1,6-alpha-mannosidase activity
GO:0008496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannan endo-1,6-beta-mannosidase activity
GO:0008496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,6-beta-mannanase activity
GO:0008496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,6-beta-mannanase activity
GO:0008496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,6-beta-D-mannan mannanohydrolase activity
GO:0008496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-alpha-D-mannosidase activity
REACT:R-BTA-352232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)
REACT:R-RNO-5671707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Rattus norvegicus)
RHEA:68485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxydodecanoate + H(+) => CO2 + H2O + undecanal
REACT:R-MMU-3907292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Mus musculus)
REACT:R-MMU-5668947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates myosin phosphatase (Mus musculus)
REACT:R-SSC-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Sus scrofa)
RHEA:66816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + tetrahydroxoborate(in) = 2 Na(+)(out) + tetrahydroxoborate(out)
REACT:R-HSA-1433501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other adapter proteins with p-KIT (Homo sapiens)
REACT:R-MMU-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Mus musculus)
REACT:R-CEL-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Caenorhabditis elegans)
REACT:R-BTA-170835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Bos taurus)
REACT:R-HSA-9008928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Homo sapiens)
RHEA:55930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:60622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate => N-hexanoyl-sphing-4-enine-1-phosphocholine
RHEA:14009	skos:altLabel	"CPPase"
RHEA:14009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chrysanthemyl diphosphate synthase"
RHEA:14009	skos:prefLabel	"chrysanthemyl diphosphate synthase"
RHEA:14009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate
REACT:R-CEL-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Caenorhabditis elegans)
GO:0102801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity
RHEA:37660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + methanol => CoA + O-methyl anthranilate
RHEA:40318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + O2 <=> (2E)-glutaconyl-CoA + H2O2
REACT:R-BTA-5686335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF2RA:CSF2RB binds SFTPs (Bos taurus)
RHEA:15512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:54164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Homo sapiens)
RHEA:65587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:36451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-glutamate(out) + H2O = ADP + glycyl-L-glutamate(in) + H(+) + phosphate
REACT:R-HSA-5696947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP47 deubiquitinates POLB (Homo sapiens)
REACT:R-BTA-8869580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEK binds TFAP2A homodimers (Bos taurus)
REACT:R-GGA-8873946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD3 deubiquitinates PTEN (Gallus gallus)
REACT:R-HSA-9613644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOX10-dependent POU3F1 gene expression (Homo sapiens)
RHEA:19219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+) => 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane
RHEA:63221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine => 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine
RHEA:42919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine
REACT:R-CFA-391157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds SKAP2 (Canis familiaris)
RHEA:30433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taraxerol => (S)-2,3-epoxysqualene
RHEA:34527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine = (S)-3-amino-3-phenylpropanoate
RHEA:34527	skos:prefLabel	"phenylalanine aminomutase (D-beta-phenylalanine forming)"
RHEA:34527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine aminomutase (D-beta-phenylalanine forming)"
EC:4.2.2.8	skos:prefLabel	"heparin-sulfate lyase"
EC:4.2.2.8	skos:altLabel	"heparitin-sulfate lyase"
EC:4.2.2.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heparin-sulfate lyase"
EC:4.2.2.8	skos:altLabel	"heparin-sulfate eliminase"
REACT:R-DDI-8854612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 accelerates GTP hydrolysis by RAB33B (Dictyostelium discoideum)
REACT:R-XTR-8848658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Xenopus tropicalis)
REACT:R-SPO-9668419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Schizosaccharomyces pombe)
EC:3.2.1.155	skos:prefLabel	"xyloglucan-specific endo-processive beta-1,4-glucanase"
EC:3.2.1.155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xyloglucan-specific endo-processive beta-1,4-glucanase"
EC:3.2.1.155	skos:altLabel	"[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase"
EC:3.2.1.155	skos:altLabel	"xyloglucan-specific exo-beta-1,4-glucanase"
RHEA:54398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:19605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a chlorophyll + H2O = a chlorophyllide + H(+) + phytol
RHEA:67629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dGMP + L-aspartate => (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate
REACT:R-RNO-4641134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds AXIN (Rattus norvegicus)
RHEA:22846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Bos taurus)
RHEA:70419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetyl-CoA + H2O = 3,4-dihydroxyphenylacetate + CoA + H(+)
REACT:R-HSA-549364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SERPINE1 (PAI-1) (Homo sapiens)
REACT:R-BTA-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Bos taurus)
REACT:R-DME-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Drosophila melanogaster)
REACT:R-DRE-5138441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A-FZD4 recruits DVL2 (Danio rerio)
REACT:R-XTR-5654647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
REACT:R-MMU-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Mus musculus)
RHEA:58325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine
REACT:R-DME-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Drosophila melanogaster)
REACT:R-BTA-2632521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Bos taurus)
REACT:R-CFA-2176475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)
RHEA:19289	skos:altLabel	"sucrose phosphatase"
RHEA:19289	skos:prefLabel	"sucrose-phosphate phosphatase"
RHEA:19289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sucrose-phosphate phosphatase"
RHEA:19289	skos:altLabel	"sucrose-6-phosphate phosphatase"
RHEA:19289	skos:altLabel	"SPP"
RHEA:19289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sucrose 6(F)-phosphate = phosphate + sucrose
REACT:R-HSA-4420117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR2 autophosphorylates (Homo sapiens)
REACT:R-HSA-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Homo sapiens)
REACT:R-MMU-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Mus musculus)
RHEA:24730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + H(+) = aniline + CO2
RHEA:62199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + propan-2-ol <=> acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-BTA-9029680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-7 translocates to the nucleus (Bos taurus)
REACT:R-CFA-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)
RHEA:15053	skos:altLabel	"2-amino-N-ribosylacetamide 5'-phosphate transformylase"
RHEA:15053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosylglycinamide formyltransferase 1"
RHEA:15053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide
RHEA:15053	skos:altLabel	"GAR transformylase"
RHEA:15053	skos:altLabel	"GAR formyltransferase"
RHEA:15053	skos:altLabel	"5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase"
RHEA:15053	skos:prefLabel	"phosphoribosylglycinamide formyltransferase 1"
RHEA:15053	skos:altLabel	"5'-phosphoribosylglycinamide transformylase"
RHEA:15053	skos:altLabel	"GAR TFase"
RHEA:15053	skos:altLabel	"GART"
RHEA:15053	skos:altLabel	"glycinamide ribonucleotide transformylase"
RHEA:49603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + octanedioate <=> AMP + diphosphate + octanedioyl-CoA
REACT:R-DRE-6803545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to phagosomal lumen (Danio rerio)
RHEA:67196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylserotonin = acetate + serotonin
REACT:R-MMU-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)
REACT:R-DDI-5668718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:RAC1:GTP generates superoxide from oxygen (Dictyostelium discoideum)
REACT:R-DME-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)
REACT:R-SSC-2730863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 by PKC-theta (Sus scrofa)
REACT:R-HSA-9729542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTOP1 transports H+ from the extracellular region to the cytosol (Homo sapiens)
REACT:R-MMU-1889978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALT6 transfers Gal to the tetrasaccharide linker (Mus musculus)
REACT:R-DRE-3697894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN2 (Danio rerio)
RHEA:55540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] = 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate
RHEA:55540	skos:prefLabel	"vanadium-dependent nitrogenase"
RHEA:55540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vanadium-dependent nitrogenase"
REACT:R-MMU-9018785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds GTP (Mus musculus)
REACT:R-MMU-8878914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Mus musculus)
REACT:R-HSA-9034862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 binds SHC1 (Homo sapiens)
REACT:R-BTA-9614564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO4 (Bos taurus)
RHEA:13664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formimidoyl-L-aspartate <=> N-formyl-L-aspartate + NH4(+)
REACT:R-HSA-6805943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A1 binds TLR4:LY96 (Homo sapiens)
REACT:R-DME-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Drosophila melanogaster)
REACT:R-GGA-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Gallus gallus)
REACT:R-HSA-3209151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-24 binds p16INK4A and p14ARF mRNAs (Homo sapiens)
REACT:R-GGA-4551649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO1 (Gallus gallus)
REACT:R-RNO-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Rattus norvegicus)
GO:0090683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled receptor sweet taste receptor activity
GO:0090683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR sweet taste receptor activity
REACT:R-HSA-266303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds C and E apolipoproteins (Homo sapiens)
RHEA:68675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-PFA-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Plasmodium falciparum)
RHEA:25315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = L-2-acetamido-6-oxoheptanedioate + L-glutamate
REACT:R-XTR-5607023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IXa associates with cell membrane (Xenopus tropicalis)
GO:0046982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein heterodimerization activity
RHEA:43602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3R-hydroxyeicosanoyl-[ACP] + NADP(+) => 3-oxoeicosanoyl-[ACP] + H(+) + NADPH
REACT:R-CEL-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)
RHEA:37179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-BTA-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Bos taurus)
REACT:R-SSC-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)
RHEA:33673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2 => an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CFA-4332359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active calmodulin binds CAMK2 (Canis familiaris)
RHEA:44532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine
RHEA:42085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinal + H2O + NAD(+) => 9-cis-retinoate + 2 H(+) + NADH
REACT:R-XTR-376357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp7 associated Lysosome to Plasma membrane transport (Xenopus tropicalis)
RHEA:26044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-9-O-acetylneuraminate
REACT:R-SSC-191830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP nuclear import and release (Sus scrofa)
REACT:R-RNO-5669097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA trimer binds TNFRSF1A,1B,14 (Rattus norvegicus)
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lactoperoxidase activity
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	extensin peroxidase
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	secretory plant peroxidase activity
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	japanese radish peroxidase
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heme peroxidase
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	guaiacol peroxidase
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	donor:hydrogen-peroxide oxidoreductase activity
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxidase activity
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxidase reaction
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protoheme peroxidase
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myeloperoxidase activity
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MPO
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	horseradish peroxidase (HRP)
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxyperoxidase activity
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	verdoperoxidase
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thiocyanate peroxidase
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial catalase-peroxidase activity
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	eosinophil peroxidase activity
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	scopoletin peroxidase
GO:0004601	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pyrocatechol peroxidase
RHEA:45635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
EC:3.4.19.-	skos:prefLabel	"Omega peptidases"
EC:3.4.19.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Omega peptidases"
RHEA:51528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + vanillate = CO2 + guaiacol
REACT:R-MMU-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Mus musculus)
REACT:R-HSA-352029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)
GO:0032137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine/thymine mispair binding
GO:0032137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G/T mispair binding
GO:0032137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T/G mispair binding
GO:0032137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine/guanine mispair binding
GO:0008979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prophage integrase activity
GO:0008979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	integrase activity involved in establishment of integrated proviral latency
REACT:R-DDI-4570489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO2 (Dictyostelium discoideum)
REACT:R-MMU-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Mus musculus)
RHEA:55216	skos:prefLabel	"rhizathalene A synthase"
RHEA:55216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + rhizathalene A
RHEA:55216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhizathalene A synthase"
RHEA:54481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
REACT:R-XTR-376369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp2 associated secretory vesicle to plasma membrane transport (Xenopus tropicalis)
RHEA:22805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S,9R)-vomifoliol + NAD(+) => (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH
REACT:R-MMU-211206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of DFF to the nucleus (Mus musculus)
REACT:R-BTA-3780994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Bos taurus)
RHEA:40489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:47848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate
REACT:R-SPO-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Schizosaccharomyces pombe)
RHEA:18943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH => a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+)
REACT:R-BTA-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Bos taurus)
REACT:R-SPO-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Schizosaccharomyces pombe)
REACT:R-CFA-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Canis familiaris)
RHEA:37393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:64354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA
REACT:R-RNO-9700175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates SHC1 (Rattus norvegicus)
REACT:R-MMU-2213235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of nonameric complex in the endocytic pathway (Mus musculus)
REACT:R-HSA-199219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Homo sapiens)
REACT:R-MMU-5607725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Mus musculus)
REACT:R-CFA-5216234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)
REACT:R-DDI-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Dictyostelium discoideum)
REACT:R-GGA-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Gallus gallus)
REACT:R-BTA-174456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments of the C-strand (Bos taurus)
RHEA:49987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + jasmonate + NADPH + O2 <=> (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)
REACT:R-SSC-5672972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)
EC:6.5.1.2	skos:altLabel	"polydeoxyribonucleotide synthase (NAD+)"
EC:6.5.1.2	skos:altLabel	"polydeoxyribonucleotide synthase (NAD(+))"
EC:6.5.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA ligase (NAD(+))"
EC:6.5.1.2	skos:altLabel	"polynucleotide ligase (NAD(+))"
EC:6.5.1.2	skos:altLabel	"DNA repair enzyme"
EC:6.5.1.2	skos:altLabel	"polynucleotide ligase (NAD+)"
EC:6.5.1.2	skos:prefLabel	"DNA ligase (NAD(+))"
EC:6.5.1.2	skos:altLabel	"DNA joinase"
REACT:R-CEL-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Caenorhabditis elegans)
RHEA:67827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O <=> a lipid X + 2 H(+) + UMP
REACT:R-GGA-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)
REACT:R-PFA-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Plasmodium falciparum)
REACT:R-CFA-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Canis familiaris)
REACT:R-CFA-202365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
RHEA:61124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin
REACT:R-MMU-1250357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds P-ERBB4 isoform dimers (Mus musculus)
RHEA:11897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol + NAD(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH
REACT:R-HSA-9683751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M protein gets N-glycosylated (Homo sapiens)
REACT:R-CFA-9613264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Canis familiaris)
RHEA:33261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formimidoylglycine + NH4(+) => 4-aminoimidazole + H(+) + 2 H2O
RHEA:64921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate
REACT:R-MMU-2562526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates OPTN (Mus musculus)
REACT:R-SSC-5358340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoproteolytic cleavage of Hh precursors (Sus scrofa)
RHEA:15100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formimidoyltetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate
REACT:R-DRE-5694442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH2,3 bind GRIA1 (Danio rerio)
REACT:R-CFA-8871376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds PI3P (Canis familiaris)
REACT:R-GGA-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Gallus gallus)
RHEA:50901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O => (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate
RHEA:10830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + anthraniloyl-CoA + diphosphate => anthranilate + ATP + CoA
REACT:R-CEL-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Caenorhabditis elegans)
GO:0052813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol bisphosphate kinase activity
REACT:R-DRE-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Danio rerio)
REACT:R-DME-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)
REACT:R-CFA-9603302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (peptide) binds IIa (Canis familiaris)
RHEA:42485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-sorbitol 6-phosphate(in) + L-histidyl-[protein]
REACT:R-RNO-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Rattus norvegicus)
RHEA:17932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + ATP <=> ADP + an N-acylsphing-4-enine 1-phosphate + H(+)
REACT:R-CFA-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Canis familiaris)
REACT:R-MMU-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Mus musculus)
REACT:R-DME-428231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Drosophila melanogaster)
RHEA:30770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucurono-3,6-lactone + H2O <=> D-glucuronate + H(+)
RHEA:48785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrulose 4-phosphate => D-erythrose 4-phosphate
RHEA:36128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A34 + S-adenosyl-L-methionine => O-methyl gibberellin A34 + S-adenosyl-L-homocysteine
RHEA:51030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloroindole-3-pyruvate imine dimer + 2 H2O => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2
REACT:R-HSA-8850326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds self-lipid-based antigen via CD1 (Homo sapiens)
RHEA:58827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9694794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA3 is translated to protein 3a (Homo sapiens)
REACT:R-CFA-163625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon binds to Glucagon receptor (Canis familiaris)
REACT:R-RNO-8939335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 polyubiquinates BCL10 (Rattus norvegicus)
RHEA:38234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA
RHEA:15472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide <=> 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
RHEA:49111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine
RHEA:53329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2,3-diacyl-alpha-D-glucosamine => 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP
REACT:R-RNO-2730876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IKK-beta by TAK1 (Rattus norvegicus)
REACT:R-SSC-193694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 is recruited and forms a complex with TRAF6 (Sus scrofa)
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	androstenedione 5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta4-3-ketosteroid 5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	androstenedione 5-beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	testosterone 5-beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta4-3-oxosteroid 5-beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-delta4-steroid 5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(4)-5-beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cortisone delta4-5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 5-beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta4-3-oxosteroid 5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	testosterone 5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholestenone 5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-Delta(4)-steroid 5-beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone b-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(4)-hydrogenase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cortisone 5-beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cortisone 5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	5-beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestenone 5b-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta(4)-3-ketosteroid 5-beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestenone 5-beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta4-hydrogenase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta4-5beta-reductase activity
GO:0047787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cortisone delta(4)-5-beta-reductase activity
REACT:R-RNO-9604487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7:p-IRF7 translocates to the nucleus (Rattus norvegicus)
GO:0015391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleobase:cation symporter activity
REACT:R-MMU-5654584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS bind to PPTN11 (Mus musculus)
RHEA:44397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:44912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (3E)-hexenoyl-CoA + NADP(+)
REACT:R-HSA-444047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR3 binds carboxylates (Homo sapiens)
RHEA:52676	skos:prefLabel	"[amino group carrier protein]-ornithine hydrolase"
RHEA:52676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[amino group carrier protein]-ornithine hydrolase"
RHEA:52676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine
REACT:R-RNO-2230983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP1:Hemopexin:heme is endocytosed (Rattus norvegicus)
REACT:R-MMU-4546387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VDR with SUMO2 (Mus musculus)
RHEA:66613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA => methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]
REACT:R-SSC-349637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spherical HDL and SR-BI receptor form a complex at the cell surface (Sus scrofa)
REACT:R-HSA-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Homo sapiens)
REACT:R-BTA-8877902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated AR binds RUNX2 (Bos taurus)
REACT:R-BTA-450620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S193-KSRP binds 14-3-3zeta in the nucleus (Bos taurus)
REACT:R-HSA-3322019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-b (Homo sapiens)
REACT:R-MMU-2028583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS2 (Mus musculus)
REACT:R-HSA-917811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3-like proteins reduce Fe3+ to Fe2+ (Homo sapiens)
RHEA:54409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
REACT:R-BTA-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Bos taurus)
RHEA:40979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate
RHEA:56173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + O2 => 8-demethyl-8-formylriboflavin 5'-phosphate + H2O
RHEA:29063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + formate + H(+) = a menaquinol + CO2
REACT:R-XTR-6785732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases bind monoubiquitinated ID2 complex (Xenopus tropicalis)
REACT:R-GGA-2132064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antigen bound antibody interacts with C1complement complex (Gallus gallus)
REACT:R-MMU-5696968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP20, USP33 deubiquitinate ADRB2 (Mus musculus)
RHEA:52597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholoyl-CoA + NAD(+) => 3-oxocholan-24-oyl-CoA + H(+) + NADH
RHEA:16277	skos:altLabel	"IAAld oxidase"
RHEA:16277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-acetaldehyde oxidase"
RHEA:16277	skos:altLabel	"indoleacetaldehyde oxidase"
RHEA:16277	skos:prefLabel	"indole-3-acetaldehyde oxidase"
RHEA:16277	skos:altLabel	"IAA oxidase"
RHEA:16277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-acetaldehyde + O2 = (indol-3-yl)acetate + H(+) + H2O2
RHEA:19564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADPH + O2 <=> H2O + NADP(+) + testololactone
REACT:R-CFA-879594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO4C1 mediates the transport of digoxin (Canis familiaris)
REACT:R-DDI-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)
REACT:R-DME-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Drosophila melanogaster)
REACT:R-GGA-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Gallus gallus)
REACT:R-MMU-8869506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Mus musculus)
RHEA:56518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 4 H2O + heme b => Fe-coproporphyrin III + 2 H(+) + 2 H2O2
RHEA:62481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-GGA-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
REACT:R-MMU-1237325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A is protonated and carbamated causing release of oxygen (Mus musculus)
REACT:R-DRE-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Danio rerio)
RHEA:14216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-fructose 1-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)
RHEA:23178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AMP + diphosphate => acetate + ATP + CoA
REACT:R-BTA-2161293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin forms aggregate globules (Bos taurus)
REACT:R-GGA-1470009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs (Gallus gallus)
RHEA:30850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + glutaryl-CoA + 2 H(+) <=> (2E)-butenoyl-CoA + CO2 + FADH2
REACT:R-BTA-5672957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates KSR1 (Bos taurus)
REACT:R-DRE-211910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Danio rerio)
RHEA:12494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methionine => L-methionine
REACT:R-SCE-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Saccharomyces cerevisiae)
REACT:R-XTR-6804527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INTL1 binds bacterial glycans (Xenopus tropicalis)
REACT:R-HSA-8948703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)
REACT:R-HSA-5687105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF2BP1 represses translation of MAPK4 mRNA (Homo sapiens)
GO:0015111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide transmembrane transporter activity
RHEA:46741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrodesmosterol + H(+) + NADPH => desmosterol + NADP(+)
REACT:R-XTR-5617816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A  (Xenopus tropicalis)
REACT:R-HSA-1475028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Homo sapiens)
REACT:R-SSC-1482543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Sus scrofa)
REACT:R-MMU-2730903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of TRAF6 (Mus musculus)
REACT:R-RNO-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Rattus norvegicus)
REACT:R-DRE-5218806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN autophosphorylates (Danio rerio)
REACT:R-XTR-2974737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 binds MDK (Xenopus tropicalis)
RHEA:34484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => 4-hydroxybenzalacetone + 2 CO2 + 2 CoA
RHEA:45536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine
REACT:R-CFA-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Canis familiaris)
REACT:R-DME-214891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length GD is cleaved by an unknown protease (Drosophila melanogaster)
REACT:R-GGA-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Gallus gallus)
REACT:R-BTA-2247511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2:ligand is endocytosed (Bos taurus)
REACT:R-MMU-8948226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Mus musculus)
REACT:R-SCE-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Saccharomyces cerevisiae)
RHEA:51991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> 18S-resolvin E1
REACT:R-CFA-265153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Canis familiaris)
RHEA:32346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-thujan-3-ol + NAD(+) <=> (+)-thujan-3-one + H(+) + NADH
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	class II ribonucleotide reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylcobalamin-dependent ribonucleotide reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	class I ribonucleotide reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine/pyrimidine nucleoside diphosphate reduction
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aerobic non-heme iron-dependent ribonucleotide reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleoside-diphosphate reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anaerobic iron-sulfur-dependent ribonucleotide reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleoside 5'-diphosphate reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	class II ribonucleoside-diphosphate reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	class III ribonucleotide reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside diphosphate reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribonucleotide reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleotide diphosphate reductase activity
GO:0061731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNR
RHEA:60563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionyl-[protein] + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]
REACT:R-PFA-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Plasmodium falciparum)
REACT:R-RNO-389350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 by pVav1 (Rattus norvegicus)
REACT:R-GGA-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Gallus gallus)
GO:0050036	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonic acid dehydrogenase activity
GO:0050036	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonate:NAD+ 3-oxidoreductase activity
GO:0050036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonate 3-dehydrogenase activity
GO:0050036	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonate dehydrogenase activity
RHEA:53514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O
GO:0016229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid dehydrogenase activity
REACT:R-SSC-9026005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Sus scrofa)
REACT:R-BTA-192056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Bos taurus)
REACT:R-MMU-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Mus musculus)
REACT:R-MMU-1605632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Both hexosaminidase A and B can cleave GalNAc from globoside (Mus musculus)
RHEA:25234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-neuraminate => N-acetyl-beta-neuraminate
RHEA:49794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-eicosanoylglycinate => eicosanoyl-CoA + glycine
REACT:R-RNO-419428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR2-5 bind S1P (Rattus norvegicus)
REACT:R-CFA-374173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR1 (Canis familiaris)
RHEA:46470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate => an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O
REACT:R-CFA-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Canis familiaris)
REACT:R-MMU-446364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Migfilin interacts with VASP (Mus musculus)
REACT:R-BTA-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Bos taurus)
REACT:R-CEL-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Caenorhabditis elegans)
REACT:R-RNO-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Rattus norvegicus)
RHEA:49254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1-phosphate(in) + L-histidyl-[protein] => D-fructose(out) + N(pros)-phospho-L-histidyl-[protein]
REACT:R-SSC-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Sus scrofa)
REACT:R-SSC-6807027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 and PTPN2 dephosphorylate MET (Sus scrofa)
RHEA:66030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine
RHEA:27722	skos:altLabel	"Ara4FN transferase"
RHEA:27722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose = 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP
RHEA:27722	skos:prefLabel	"undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase"
RHEA:27722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase"
RHEA:27722	skos:altLabel	"undecaprenyl-phosphate Ara4FN transferase"
RHEA:27722	skos:altLabel	"polymyxin resistance protein PmrF"
RHEA:48151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b (d18:1(4E)/18:0) + H2O <=> ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate
REACT:R-MMU-166041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of LPS onto TLR4 (Mus musculus)
EC:5.1.3.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-mannose 3,5-epimerase"
EC:5.1.3.18	skos:prefLabel	"GDP-mannose 3,5-epimerase"
REACT:R-DRE-8866327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL translocates from SER lumen to extracellular region (Danio rerio)
RHEA:42101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamoyl phosphate + H2O + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate
REACT:R-SSC-9724670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds imiquimod (Sus scrofa)
RHEA:51584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"crotonobetainyl-CoA reductase"
RHEA:51584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:51584	skos:prefLabel	"crotonobetainyl-CoA reductase"
EC:5.3.3.1	skos:prefLabel	"steroid Delta-isomerase"
EC:5.3.3.1	skos:altLabel	"Delta(5)-3-ketosteroid isomerase"
EC:5.3.3.1	skos:altLabel	"Delta(5)-3-oxosteroid isomerase"
EC:5.3.3.1	skos:altLabel	"steroid isomerase"
EC:5.3.3.1	skos:altLabel	"Delta(5)-steroid isomerase"
EC:5.3.3.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steroid Delta-isomerase"
EC:5.3.3.1	skos:altLabel	"hydroxysteroid isomerase"
EC:5.3.3.1	skos:altLabel	"3-oxosteroid isomerase"
EC:5.3.3.1	skos:altLabel	"Delta(5)-3-keto steroid isomerase"
REACT:R-RNO-3858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL recruits RAC (Rattus norvegicus)
REACT:R-HSA-9701199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)
REACT:R-HSA-167683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TrkA phosphorylates PLCG1 (Homo sapiens)
REACT:R-SSC-5658430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF1 is degraded by the proteasome (Sus scrofa)
REACT:R-BTA-5649658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves DHU from damaged DNA (Bos taurus)
EC:2.7.8.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"membrane-oligosaccharide glycerophosphotransferase"
EC:2.7.8.21	skos:altLabel	"phosphoglycerol cyclase"
EC:2.7.8.21	skos:altLabel	"periplasmic phosphoglycerotransferase"
EC:2.7.8.21	skos:prefLabel	"membrane-oligosaccharide glycerophosphotransferase"
REACT:R-DRE-9020610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Danio rerio)
REACT:R-SSC-73912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Sus scrofa)
RHEA:30529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ATP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate
REACT:R-BTA-202967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of alpha-II-Fodrin (Bos taurus)
RHEA:12167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a phenol <=> adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)
RHEA:65693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine => a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine
GO:0005369	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium/chloride-dependent taurine transporter
GO:0005369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine:sodium symporter activity
EC:1.4.98.-	skos:prefLabel	"With other, known, acceptors"
EC:1.4.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
RHEA:36432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine 2'-deoxy-D-ribonucleoside + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase
RHEA:46276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malolactic enzyme"
RHEA:46276	skos:prefLabel	"malolactic enzyme"
RHEA:46276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + H(+) = (S)-lactate + CO2
RHEA:17610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[sulfatase] + S-adenosyl-L-methionine => 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine
REACT:R-XTR-209063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Xenopus tropicalis)
REACT:R-XTR-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Xenopus tropicalis)
RHEA:14720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + H2O + phosphoenolpyruvate <=> 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate
RHEA:72186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine(in) + H(+)(out) <=> creatinine(out) + H(+)(in)
RHEA:25776	skos:prefLabel	"2-keto-myo-inositol isomerase"
RHEA:25776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-keto-myo-inositol isomerase"
RHEA:25776	skos:altLabel	"inosose isomerase"
RHEA:25776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inosose = scyllo-inosine
RHEA:25776	skos:altLabel	"2KMI isomerase"
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-isopropylmalic synthetase activity
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopropylmalate synthase activity
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopropylmalate synthase activity
GO:0003852	skos:prefLabel	"2-isopropylmalate synthase"
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-IPM synthetase activity
GO:0003852	skos:altLabel	"alpha-isopropylmalate synthase"
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-isopropylmalate synthase activity
GO:0003852	skos:altLabel	"isopropylmalate synthase"
GO:0003852	skos:altLabel	"alpha-isopropylmalic synthetase"
GO:0003852	skos:altLabel	"3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)"
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-isopropylmalate synthetase activity
GO:0003852	skos:altLabel	"isopropylmalate synthetase"
GO:0003852	skos:altLabel	"alpha-isopropylmalate synthetase"
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopropylmalate synthetase activity
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)
GO:0003852	skos:altLabel	"alpha-IPM synthetase"
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
GO:0003852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-isopropylmalate synthase"
REACT:R-BTA-4656914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKBIA with SUMO1 (Bos taurus)
GO:0010174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside transmembrane transporter activity, against a concentration gradient
GO:0010174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	concentrative nucleoside transporter activity
REACT:R-MMU-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Mus musculus)
RHEA:46031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + tetradecanoate <=> (2R)-hydroxytetradecanoate + H2O
RHEA:52777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:65329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chrodrimanin F => AH2 + chrodrimanin H
RHEA:23199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine <=> 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
RHEA:42803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) <=> all-trans-4,4'-diaponeurosporene + 3 FADH2
RHEA:66161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + tyramine => CoA + H(+) + N-hexanoyltyramine
REACT:R-SSC-193407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
REACT:R-CFA-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Canis familiaris)
REACT:R-SCE-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Saccharomyces cerevisiae)
RHEA:22386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O
REACT:R-BTA-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
GO:0016492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotensin receptor activity, G-protein coupled
GO:0016492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled neurotensin receptor activity
GO:0016492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotensin receptor activity, G protein coupled
GO:0016492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled neurotensin receptor activity
GO:0016492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled neurotensin receptor activity
REACT:R-MMU-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Mus musculus)
REACT:R-CEL-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
RHEA:43003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate
RHEA:64419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylofuranose + NADP(+) <=> D-xylono-1,4-lactone + H(+) + NADPH
RHEA:49722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 H2O + NAD(+) + violacein => 2 H(+) + NADH + 2 O2 + protoviolaceinate
RHEA:44840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + octadecanoyl-CoA = CoA + O-octadecanoyl-(R)-carnitine
REACT:R-BTA-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Bos taurus)
RHEA:63473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-hexaprenol + ATP => ADP + all-trans-hexaprenyl phosphate + H(+)
REACT:R-MMU-140769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VII -> factor VIIa (Mus musculus)
REACT:R-BTA-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Bos taurus)
REACT:R-DME-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Drosophila melanogaster)
RHEA:66542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cholesta-5,7-dien-3beta,25-diol => 7-dehydrocholesterol + A + H2O
RHEA:71588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + 2-oxoglutarate(out) => (S)-malate(out) + 2-oxoglutarate(in)
REACT:R-DME-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Drosophila melanogaster)
REACT:R-DDI-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Dictyostelium discoideum)
REACT:R-XTR-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Xenopus tropicalis)
RHEA:58031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH <=> a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)
RHEA:71281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-leucine(in) + 2 Na(+)(in) => chloride(out) + L-leucine(out) + 2 Na(+)(out)
RHEA:41841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctanoyl-[ACP] + NADP(+)
GO:0033702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-trans-carveol dehydrogenase activity
GO:0033702	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-trans-carveol:NAD+ oxidoreductase activity
RHEA:52143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O <=> a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)
RHEA:52502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-5675456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)
REACT:R-XTR-5624486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylates RAF1 on Y340,Y341 (Xenopus tropicalis)
REACT:R-SSC-5357479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AXL binds PI3K (Sus scrofa)
RHEA:33119	skos:prefLabel	"(+)-sativene synthase"
RHEA:33119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-sativene synthase"
RHEA:33119	skos:altLabel	"Cop4"
RHEA:33119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate
RHEA:35909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA
REACT:R-DDI-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Dictyostelium discoideum)
REACT:R-DME-210974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS-1 to Tie2 bound  Grb2 (Drosophila melanogaster)
RHEA:43718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutamine synthetase]-L-tyrosine + ADP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate
REACT:R-MMU-5654697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
REACT:R-HSA-2408524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Homo sapiens)
REACT:R-HSA-4086393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha t2 binds and activates PDE6 (Homo sapiens)
RHEA:18212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (2S,4R)-bornyl diphosphate
REACT:R-CFA-5666070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Canis familiaris)
GO:0001058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter
GO:0001058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase V activity
REACT:R-MMU-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Mus musculus)
GO:0032867	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arabinose:NADP reductase activity
GO:0032867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinose:NADP reductase activity
GO:0032867	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arabinose reductase activity
REACT:R-SCE-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Saccharomyces cerevisiae)
RHEA:65967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurocholate(out) <=> ADP + H(+) + phosphate + taurocholate(in)
REACT:R-PFA-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Plasmodium falciparum)
REACT:R-BTA-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Bos taurus)
REACT:R-DME-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Drosophila melanogaster)
RHEA:25275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate => ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
REACT:R-RNO-111966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 binds CALM1:4Ca2+ (Rattus norvegicus)
RHEA:30114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-enterobactin + H(+) + 3 H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine
REACT:R-RNO-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)
RHEA:13377	skos:altLabel	"glucose-phosphate kinase"
RHEA:13377	skos:prefLabel	"phosphoglucokinase"
RHEA:13377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglucokinase"
RHEA:13377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + ATP = ADP + alpha-D-glucose 1,6-bisphosphate + H(+)
REACT:R-XTR-392195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi activation by P2Y purinoceptor 12 (Xenopus tropicalis)
RHEA:65518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + pre-mycofactocin => 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O
RHEA:13935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O
RHEA:51363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-leucine <=> (9Z)-octadecenoate + L-leucine
REACT:R-HSA-6799179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
REACT:R-HSA-400012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylcholine binds Muscarinic Acetylcholine Receptor M3 (Homo sapiens)
REACT:R-MMU-3249390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Mus musculus)
REACT:R-HSA-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Homo sapiens)
RHEA:44341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + ATP + fumarate => AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate
REACT:R-HSA-177925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds to the phosphorylated EGF receptor:ligand complex (Homo sapiens)
REACT:R-CFA-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Canis familiaris)
RHEA:39655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O
RHEA:48747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-yatein + 2-oxoglutarate + O2 <=> (-)-deoxypodophyllotoxin + CO2 + H2O + succinate
RHEA:40589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + octanedioate => H2O + octanedioyl-CoA
REACT:R-RNO-3134800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING dimerization (Rattus norvegicus)
REACT:R-MMU-5634729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Mus musculus)
REACT:R-XTR-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Xenopus tropicalis)
RHEA:62849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
GO:0062067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroplast photosystem I binding
RHEA:16655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)
RHEA:63161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)-taurine => (15Z)-tetracosenoate + taurine
RHEA:21258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate => 3-phosphoshikimate + phosphoenolpyruvate
RHEA:46503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + UMP <=> CO2 + phosphate + succinate + uridine-5'-aldehyde
RHEA:49003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)
REACT:R-DRE-69891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of CHEK2 by ATM (Danio rerio)
REACT:R-DME-2032775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD1 (Drosophila melanogaster)
REACT:R-SSC-5678315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Sus scrofa)
REACT:R-CEL-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Caenorhabditis elegans)
RHEA:10188	skos:altLabel	"3-hydroxy-3-methylglutaryl-coenzyme A synthase"
RHEA:10188	skos:altLabel	"HMG-CoA synthase"
RHEA:10188	skos:altLabel	"hydroxymethylglutaryl coenzyme alpha-condensing enzyme"
RHEA:10188	skos:prefLabel	"hydroxymethylglutaryl-CoA synthase"
RHEA:10188	skos:altLabel	"beta-hydroxy-beta-methylglutaryl-CoA synthase"
RHEA:10188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
RHEA:10188	skos:altLabel	"hydroxymethylglutaryl coenzyme A synthase"
RHEA:10188	skos:altLabel	"3-hydroxy-3-methylglutaryl-CoA synthase"
RHEA:10188	skos:altLabel	"acetoacetyl coenzyme A transacetase"
RHEA:10188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxymethylglutaryl-CoA synthase"
RHEA:10188	skos:altLabel	"3-hydroxy-3-methylglutaryl coenzyme A synthase"
RHEA:10188	skos:altLabel	"(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)"
RHEA:10188	skos:altLabel	"3-hydroxy-3-methylglutaryl CoA synthetase"
RHEA:10188	skos:altLabel	"3-hydroxy-3-methylglutaryl coenzyme A synthetase"
REACT:R-SSC-420593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR:PVRL3 trans heterodimer interaction (Sus scrofa)
RHEA:55275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + tetradecanoyl-CoA <=> 11-cis-retinyl tetradecanoate + CoA
RHEA:15453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + sarcosine = H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine
REACT:R-CEL-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Caenorhabditis elegans)
RHEA:64975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP + H2O <=> dUMP + H(+) + phosphate
REACT:R-CFA-74726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of insulin from insulin receptor (Canis familiaris)
REACT:R-PFA-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Plasmodium falciparum)
RHEA:27516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sphinganine => H2O + sphinganine 1-phosphate
REACT:R-MMU-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Mus musculus)
REACT:R-MMU-203716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1 complex binds to Nostrin (Mus musculus)
REACT:R-SSC-3640844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 binds RibC-AXIN:TNKS complex (Sus scrofa)
RHEA:15303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-apiose + H(+) + NADH => D-apiitol + NAD(+)
REACT:R-MMU-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Mus musculus)
RHEA:66958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose
EC:4.1.3.24	skos:altLabel	"L-malyl-CoA lyase"
EC:4.1.3.24	skos:prefLabel	"malyl-CoA lyase"
EC:4.1.3.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malyl-CoA lyase"
EC:4.1.3.24	skos:altLabel	"malyl-coenzyme A lyase"
EC:4.1.3.24	skos:altLabel	"(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase"
RHEA:17494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + glycerol => AH2 + dihydroxyacetone
RHEA:66201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pentanoyl-CoA => (2E)-pentenoyl-CoA + H2O2
REACT:R-CFA-3322429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP monoubiquinates TLE (Canis familiaris)
RHEA:50368	skos:prefLabel	"tert-amyl alcohol desaturase"
RHEA:50368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tert-amyl alcohol desaturase"
RHEA:50368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-2-ol + H(+) + NADPH + O2 = 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)
REACT:R-DRE-6804879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates TP53 (Danio rerio)
REACT:R-HSA-8867097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD99 binds CD99L2 (Homo sapiens)
REACT:R-XTR-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Xenopus tropicalis)
GO:0055102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipase inhibitor activity
EC:2.8.2.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[heparan sulfate]-glucosamine 3-sulfotransferase 1"
EC:2.8.2.23	skos:altLabel	"3-OST-1"
EC:2.8.2.23	skos:altLabel	"3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase"
EC:2.8.2.23	skos:altLabel	"heparin-glucosamine 3-O-sulfotransferase"
EC:2.8.2.23	skos:prefLabel	"[heparan sulfate]-glucosamine 3-sulfotransferase 1"
EC:2.8.2.23	skos:altLabel	"glucosaminyl 3-O-sulfotransferase"
EC:2.8.2.23	skos:altLabel	"heparan sulfate D-glucosaminyl 3-O-sulfotransferase"
RHEA:20092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-leucine <=> CoA + H(+) + N-acetyl-L-leucine
REACT:R-CFA-157849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)
RHEA:21649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prephenate => 3-phenylpyruvate + CO2 + H2O
REACT:R-HSA-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Homo sapiens)
REACT:R-DME-2179274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD3 phosphorylated in the linker region (Drosophila melanogaster)
RHEA:71142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH <=> 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)
GO:0008503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzodiazepine receptor activity
RHEA:42550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(746) in 23S rRNA => uridine(746) in 23S rRNA
REACT:R-SCE-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Saccharomyces cerevisiae)
REACT:R-SSC-1855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Sus scrofa)
REACT:R-HSA-8950364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)
RHEA:52016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate
EC:3.2.2.n1	skos:prefLabel	"cytokinin riboside 5'-monophosphate phosphoribohydrolase"
EC:3.2.2.n1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytokinin riboside 5'-monophosphate phosphoribohydrolase"
RHEA:41446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + 2 H(+) + phosphate => (1R)-(2-amino-1-hydroxyethyl)phosphonate + O2
REACT:R-DME-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Drosophila melanogaster)
REACT:R-HSA-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Homo sapiens)
REACT:R-BTA-6801766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Bos taurus)
REACT:R-CFA-3788748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL6 promoter (Canis familiaris)
RHEA:58444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-CFA-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Canis familiaris)
REACT:R-DME-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Drosophila melanogaster)
RHEA:55586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in mRNA + S-adenosyl-L-methionine
REACT:R-RNO-177925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds to the phosphorylated EGF receptor:ligand complex (Rattus norvegicus)
RHEA:57369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH => (6R)-NADPHX
GO:0034005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity
GO:0034005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-(10R)-germacrene A synthase activity
GO:0034005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GAS
GO:0034005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacrene-A synthase activity
GO:0034005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity
GO:0034005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	germacrene A synthase activity
GO:0034005	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-germacrene A synthase activity
REACT:R-SSC-2309787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS2 (Sus scrofa)
RHEA:34755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine = D-glucose + N-acyl-15-methylhexadecasphing-4-enine
RHEA:57216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-dGTP
REACT:R-SSC-2161195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Sus scrofa)
REACT:R-BTA-373714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-Heterodimerization of nephrin and KIRREL (Bos taurus)
RHEA:18047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+) => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O
RHEA:68967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanoate + O2 <=> 2-oxooctadecanoate + H2O2
RHEA:50767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-6799203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Bos taurus)
RHEA:35981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + fumitremorgin A => dimethylallyl diphosphate + verruculogen
REACT:R-CFA-2534248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP2, MMP3, MMP7 (Canis familiaris)
RHEA:19439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(beta-D-glucosyl)nicotinate + UDP => nicotinate + UDP-alpha-D-glucose
RHEA:12400	skos:prefLabel	"nicotinamide-nucleotide amidase"
RHEA:12400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + H2O = NH4(+) + nicotinate beta-D-ribonucleotide
RHEA:12400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinamide-nucleotide amidase"
RHEA:11081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + H2O => phosphate + thymidine
REACT:R-MMU-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Mus musculus)
GO:0015221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide transmembrane transporter activity
GO:0015221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS transmembrane transporter activity
REACT:R-DME-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Drosophila melanogaster)
RHEA:72658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine + NADPH + O2 <=> 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)
REACT:R-MMU-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Mus musculus)
REACT:R-DDI-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Dictyostelium discoideum)
REACT:R-CFA-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Canis familiaris)
RHEA:19916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + NAD(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADH
RHEA:53859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + ursocholate <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH
RHEA:60973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + NAD(+) => H(+) + hexanal + NADH
RHEA:39974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate <=> 2-aminobut-2-enoate
REACT:R-DRE-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Danio rerio)
RHEA:32997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA
REACT:R-XTR-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Xenopus tropicalis)
REACT:R-CFA-6791016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB binds itself (Canis familiaris)
REACT:R-SSC-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)
REACT:R-MMU-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Mus musculus)
RHEA:38239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA
GO:0047223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	elongation 3beta-GalNAc-transferase activity
GO:0047223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity
GO:0047223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
GO:0047223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	elongation 3-beta-GalNAc-transferase activity
GO:0047223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)
GO:0047223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity
REACT:R-HSA-4720432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Homo sapiens)
REACT:R-CEL-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Caenorhabditis elegans)
REACT:R-HSA-6785126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
GO:0016920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyroglutamyl-peptidase activity
REACT:R-GGA-76054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Gallus gallus)
REACT:R-SSC-6814695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PERP binds desmosomes (Sus scrofa)
REACT:R-HSA-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Homo sapiens)
REACT:R-GGA-5610746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI3 (Gallus gallus)
GO:0047358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity
GO:0047358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose-glycoprotein glucose phosphotransferase activity
GO:0047358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:glycoprotein glucose-1-phosphotransferase activity
GO:0047358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Glc-phosphotransferase activity
GO:0047358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity
GO:0047358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-glycoprotein glucose phosphotransferase activity
GO:0047358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GlcPTase activity
GO:0047358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity
REACT:R-DRE-9691566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 binds nicorandil (Danio rerio)
RHEA:18369	skos:prefLabel	"glycerol-3-phosphate oxidase"
RHEA:18369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-3-phosphate oxidase"
RHEA:18369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H2O2
RHEA:18369	skos:altLabel	"alpha-glycerophosphate oxidase"
REACT:R-CFA-9625482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated EGFR (Canis familiaris)
GO:1990965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosylglucuronate decarboxylase activity
RHEA:59641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotetraose + O2 => D-xylotetraono-1,5-lactone + H2O2
RHEA:25498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S)-beta-pinene + diphosphate => (2E)-geranyl diphosphate
RHEA:35167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	minocycline(in) = minocycline(out)
RHEA:24770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide b + H(+) + NADH => 7(1)-hydroxychlorophyllide a + NAD(+)
REACT:R-BTA-8982637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins binds G alpha-t (Bos taurus)
RHEA:30503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-glutamate 5-semialdehyde = acetate + L-glutamate 5-semialdehyde
REACT:R-MMU-5668534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Mus musculus)
RHEA:38573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(out) => a 1,2-diacyl-sn-glycero-3-phosphocholine(in)
REACT:R-CEL-2161814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Caenorhabditis elegans)
REACT:R-RNO-6814695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PERP binds desmosomes (Rattus norvegicus)
REACT:R-MMU-2022378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Mus musculus)
REACT:R-CEL-8876616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND6A,B exchange GTP for GDP on RAB14 (Caenorhabditis elegans)
REACT:R-HSA-1971487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHSY3 transfer GalNAc to chondroitin (Homo sapiens)
REACT:R-HSA-1299487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Precursor proteins enter TIMM23 SORT (Homo sapiens)
RHEA:28156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate
REACT:R-RNO-159819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Rattus norvegicus)
RHEA:63931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:15320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-deoxy-alpha-D-glucoside + H2O <=> 2-deoxy-D-glucose + an alcohol
RHEA:59121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) => 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2
REACT:R-RNO-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Rattus norvegicus)
RHEA:37040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O
RHEA:67898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine => a 3'-end uridylyl-adenosine-RNA
REACT:R-DME-2127257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Drosophila melanogaster)
REACT:R-XTR-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Xenopus tropicalis)
REACT:R-GGA-353430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Pol eta to a DNA template containing a lesion (Gallus gallus)
REACT:R-RNO-1604722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP9 by proteases (Rattus norvegicus)
GO:0140812	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	orotate:organic anion antiporter activity
GO:0140812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orotate:anion antiporter activity
GO:0046659	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	secretin
GO:0046659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digestive hormone activity
RHEA:52072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)
REACT:R-SSC-110011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Grb10 to the insulin receptor (Sus scrofa)
REACT:R-RNO-73635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Rattus norvegicus)
RHEA:42726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine
RHEA:18059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + hnu + oxidized Watasenia luciferin => O2 + Watasenia luciferin
REACT:R-GGA-5654673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Gallus gallus)
RHEA:56088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + globoside MSGG = CMP + globoside DSGG + H(+)
RHEA:55094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + sucrose + UDP => D-fructose + UDP-alpha-D-glucose
REACT:R-DRE-2002466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of allysine by LOX (Danio rerio)
REACT:R-MMU-69299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds geminin (Mus musculus)
GO:0055053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose:proton symporter activity
GO:0055053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose:hydrogen symporter activity
RHEA:13687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH => lathosterol + NADP(+)
GO:0015125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bile acid transmembrane transporter activity
RHEA:55554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine
REACT:R-GGA-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Gallus gallus)
RHEA:58920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (+)-medicarpin + H2O
REACT:R-CEL-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Caenorhabditis elegans)
REACT:R-CFA-8987012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)
REACT:R-HSA-9750001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Homo sapiens)
GO:0018603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrobenzene 1,2-dioxygenase activity
RHEA:18946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[collagen] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]
REACT:R-XTR-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Xenopus tropicalis)
RHEA:41227	skos:prefLabel	"4-hydroxymandelate oxidase"
RHEA:41227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelate + O2 = 4-hydroxyphenylglyoxylate + H2O2
RHEA:41227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxymandelate oxidase"
RHEA:58441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine
RHEA:50218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
REACT:R-SSC-937337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Sus scrofa)
RHEA:64535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-SCE-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Saccharomyces cerevisiae)
RHEA:30357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + methanol => a quinol + methane + O2
REACT:R-CFA-177924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
RHEA:17775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-cysteinyl-tRNA(Cys) => ATP + L-cysteine + tRNA(Cys)
RHEA:14708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CoA + NADP(+) <=> CoA-disulfide + H(+) + NADPH
REACT:R-DRE-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Danio rerio)
REACT:R-CEL-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Caenorhabditis elegans)
RHEA:58623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-decanoyl-(2S)-hydroxyglycine <=> decanamide + glyoxylate
RHEA:14136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-446868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Interleukin 1 receptor complex binds Tollip (Homo sapiens)
RHEA:23163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnopyranose <=> L-rhamnulose
REACT:R-DRE-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Danio rerio)
GO:0070699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II activin receptor binding
REACT:R-RNO-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Rattus norvegicus)
RHEA:60989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hex-2-en-1-ol + NAD(+) => (E)-hex-2-enal + H(+) + NADH
REACT:R-BTA-4088130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds FOXM1 (Bos taurus)
RHEA:72577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O
REACT:R-BTA-448632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimerizes (Bos taurus)
REACT:R-DRE-177925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds to the phosphorylated EGF receptor:ligand complex (Danio rerio)
REACT:R-SSC-177157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Sus scrofa)
GO:0015172	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acidic amino acid transporter activity
GO:0015172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acidic amino acid transmembrane transporter activity
GO:0015172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Homo sapiens)
RHEA:47558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + taurine => H2O + taurodeoxycholate
REACT:R-SSC-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)
RHEA:11741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + NADP(+) => glutathione disulfide + H(+) + NADPH
RHEA:69913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(in) + 2 Na(+)(in) => adenosine(out) + 2 Na(+)(out)
GO:0106420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent protein biotinidase activity
GO:0106420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:10855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + leachianone G <=> diphosphate + sophoraflavanone G
RHEA:15022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + L-quinate => 4-O-feruloyl-D-quinate + CoA
REACT:R-HSA-1234177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
REACT:R-HSA-5665982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Homo sapiens)
RHEA:30784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + H2O + NAD(+) => (R)-glycerate + 2 H(+) + NADH
REACT:R-MMU-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)
RHEA:70527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acyl-3-oxosphinganine + NADH = an N-acylsphinganine + NAD(+)
RHEA:16614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an arylamine => an N-acetylarylamine + CoA
GO:0022885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacteriocin transmembrane transporter activity
REACT:R-HSA-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)
REACT:R-MMU-6808496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)
RHEA:69877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-1234164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)
REACT:R-HSA-5368580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Homo sapiens)
RHEA:71725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanyl-L-leucyl-L-alanine(in) => H(+)(out) + L-alanyl-L-leucyl-L-alanine(out)
RHEA:57602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-CEL-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Caenorhabditis elegans)
REACT:R-CFA-9693324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disulfiram covalently modifies Cys191 in GSDMD (Canis familiaris)
RHEA:67448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal
REACT:R-XTR-3451153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits TRRAP/KAT5 HAT components (Xenopus tropicalis)
RHEA:67456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-9706345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Xenopus tropicalis)
RHEA:59573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-homocarnosine => 4-aminobutanoate + L-histidine
REACT:R-XTR-111742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)
REACT:R-HSA-6797627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPG hydrolyses L-Asn to L-Asp (Homo sapiens)
RHEA:62213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] => gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-succinylglutathione hydrolase activity
REACT:R-HSA-5654620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
RHEA:32850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol
REACT:R-SCE-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Saccharomyces cerevisiae)
RHEA:58463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphocholine <=> a monoacyl-sn-glycero-3-phosphocholine + CoA
RHEA:29350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + orotate(in) <=> 2 H(+)(out) + orotate(out)
GO:0102670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity
GO:0102670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase"
GO:0102670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine = (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine
GO:0102670	skos:prefLabel	"2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase"
REACT:R-HSA-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Homo sapiens)
REACT:R-CEL-216050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Caenorhabditis elegans)
REACT:R-RNO-171122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL + LDLR => LDL:LDLR complex (Rattus norvegicus)
REACT:R-SCE-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Saccharomyces cerevisiae)
REACT:R-XTR-1592349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14 (MT1-MMP) binds TIMP2 (Xenopus tropicalis)
RHEA:32901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin] => 1,8-cineole + O2 + reduced [flavodoxin]
REACT:R-SSC-9604767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 dimer autophosphorylates (Sus scrofa)
RHEA:20495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine
RHEA:72772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:18042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DRE-193789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Danio rerio)
REACT:R-BTA-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Bos taurus)
RHEA:18392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xylose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-xylose
RHEA:67229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA => (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O
REACT:R-DME-888577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GABA by GAD2 (Drosophila melanogaster)
REACT:R-BTA-5218643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90AA1 binds p-6Y-VEGFR2 (Bos taurus)
REACT:R-RNO-2161950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Rattus norvegicus)
RHEA:41927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctadecanoyl-[ACP] <=> (2E)-octadecenoyl-[ACP] + H2O
REACT:R-MMU-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Mus musculus)
RHEA:35376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O => (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate
RHEA:16869	skos:altLabel	"arachidonate omega(6) lipoxygenase"
RHEA:16869	skos:altLabel	"15-lipoxygenase"
RHEA:16869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arachidonate 15-lipoxygenase"
RHEA:16869	skos:prefLabel	"arachidonate 15-lipoxygenase"
RHEA:16869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
REACT:R-CFA-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Canis familiaris)
REACT:R-CFA-6814096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds SCOC (Canis familiaris)
RHEA:59794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + yersinopine
GO:0018857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorobenzoate-CoA ligase activity
RHEA:23977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + ATP => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate
RHEA:69894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + thymidine(out) <=> Na(+)(in) + thymidine(in)
REACT:R-RNO-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Rattus norvegicus)
RHEA:53394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-4551768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO2,3 (Xenopus tropicalis)
REACT:R-CFA-5625796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM4C binds KLK2 and KLK3 promoters (Canis familiaris)
RHEA:17035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,3-diol + H(+) + NADH => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)
REACT:R-CFA-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Canis familiaris)
REACT:R-RNO-198941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCAM1 binds Integrin alpha4beta1 (Rattus norvegicus)
GO:0047742	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chenodeoxycholoyltaurine amidohydrolase activity
GO:0047742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyltaurine hydrolase activity
RHEA:14140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine <=> 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
RHEA:22598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + deacetylcephalosporin C + H(+) => cephalosporin C + H2O
REACT:R-CEL-9010815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLITs bind keratan sulfate (Caenorhabditis elegans)
REACT:R-DRE-5251942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hikeshi binds HSP70s:ATP (Danio rerio)
GO:0032546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonucleoside binding
RHEA:15565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-amino acid + H2O = a carboxylate + an L-alpha-amino acid
REACT:R-DRE-3002811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates PLK1 (Danio rerio)
REACT:R-HSA-174445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap on the C-strand (Homo sapiens)
RHEA:24325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocineole + H(+) + NADPH + O2 => 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)
REACT:R-DDI-389639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Dictyostelium discoideum)
RHEA:52569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone + UDP-alpha-D-glucuronate => epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-SCE-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)
RHEA:60710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemate + 2 H(+) + NADH => (1R,3R)-chrysanthemal + H2O + NAD(+)
REACT:R-DDI-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Dictyostelium discoideum)
REACT:R-RNO-380574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine synaptic vesicle docking and priming (Rattus norvegicus)
REACT:R-CEL-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)
REACT:R-DRE-6786652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIT1 hydrolyses CHIT to 3xADGP (Danio rerio)
REACT:R-CFA-9014456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOG (Canis familiaris)
REACT:R-RNO-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Rattus norvegicus)
RHEA:57483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydodecanoate + H2O2 <=> 2,3-dihydroxydodecanoate + H2O
GO:0004655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-aminolevulinate dehydratase activity
GO:0004655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-aminolevulinic acid dehydrase activity
GO:0004655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	porphobilinogen synthase activity
GO:0004655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminolevulinic dehydratase activity
GO:0004655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-levulinic acid dehydratase activity
GO:0004655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta-aminolevulinic dehydratase activity
GO:0004655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-aminolevulinic acid dehydratase activity
GO:0004655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)
GO:0004655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
GO:0004655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminolevulinate dehydratase activity
REACT:R-BTA-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Bos taurus)
RHEA:25977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:60418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 => diglucosyl-enterobactin + H2O
REACT:R-CFA-8853755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Canis familiaris)
RHEA:43102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(44) in tRNA(Ser)
RHEA:40831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
RHEA:36849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + FMN-L-threonyl-[protein] + H(+) => FAD + L-threonyl-[protein]
GO:0004630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline phosphatase activity
GO:0004630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipophosphodiesterase II activity
GO:0004630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lecithinase D activity
GO:0004630	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylcholine phosphatidohydrolase activity
GO:0004630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase D activity
REACT:R-DME-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Drosophila melanogaster)
RHEA:45409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H(+) + NADH => dodecanoyl-CoA + NAD(+)
REACT:R-RNO-5625416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anterograde IFT (Rattus norvegicus)
RHEA:46208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + eicosanoate = AMP + diphosphate + eicosanoyl-CoA
REACT:R-MMU-936963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization (Mus musculus)
REACT:R-MMU-9728150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 binds gliflozins (Mus musculus)
RHEA:12788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alditol + NAD(+) <=> an aldose + H(+) + NADH
RHEA:70298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-sulfino-L-alanine <=> 3-sulfinopyruvate + L-glutamate
RHEA:49808	skos:prefLabel	"1-butanol dehydrogenase (quinone)"
RHEA:49808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-butanol dehydrogenase (quinone)"
RHEA:49808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + butan-1-ol = a quinol + butanal
RHEA:27691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dGDP => ADP + dGTP
REACT:R-DME-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Drosophila melanogaster)
REACT:R-SSC-9027043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYPs hydroxylate DHA to 14(R)-HDHA (Sus scrofa)
RHEA:41531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-[ACP] + H(+) + NADH <=> NAD(+) + octanoyl-[ACP]
RHEA:30115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + H2O = decanoate + H(+) + holo-[ACP]
REACT:R-HSA-166168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)
REACT:R-DRE-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)
REACT:R-GGA-420580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:PVRL3 trans heterodimer formation (Gallus gallus)
RHEA:63033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acylamide + H2O => a fatty acid + NH4(+)
REACT:R-MMU-5682802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI3 binds ADAM22,23,synatxin1 (Mus musculus)
GO:0051922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol sulfotransferase activity
GO:0051922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)
REACT:R-CEL-193064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3-like proteins reducde ANDST to TEST (Caenorhabditis elegans)
REACT:R-XTR-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)
RHEA:16776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GM1 (d18:1(4E)) + H(+) + UDP
RHEA:71187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine(out) + L-tryptophan(in) = 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)
REACT:R-DME-73616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)
RHEA:44433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acylglycerol => a 1,2-diacylglycerol + glycerol
RHEA:57200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + L-arginyl-[protein] = N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]
RHEA:69380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-methylpentanoate + O2 = 4-methyl-2-oxopentanoate + H2O2
REACT:R-DDI-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Dictyostelium discoideum)
REACT:R-SSC-177926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of PAG by SHP2 (Sus scrofa)
REACT:R-HSA-6801209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the TRIAP1 gene (Homo sapiens)
RHEA:68741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxocholesterol + H(+) + NADPH => 7alpha-hydroxycholesterol + NADP(+)
RHEA:70947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan(in) = L-tryptophan(out)
RHEA:62424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + H2O = 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA
REACT:R-BTA-1008200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 binds the beta globin locus control region (Bos taurus)
REACT:R-CFA-6785821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS5,(SOCS1) bind IL4RA (Canis familiaris)
RHEA:55893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 => a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)
REACT:R-GGA-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Gallus gallus)
RHEA:44822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-13 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+)
RHEA:58532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + H2O = akuammicine + formate + H(+)
REACT:R-XTR-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Xenopus tropicalis)
REACT:R-CFA-9024872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 17(S)-Hp-DHA to PDX (Canis familiaris)
REACT:R-HSA-77586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Homo sapiens)
RHEA:12676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic amide <=> a nitrile + H2O
REACT:R-DME-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Drosophila melanogaster)
RHEA:10852	skos:altLabel	"LG 2''-dimethylallyltransferase"
RHEA:10852	skos:altLabel	"LGDT"
RHEA:10852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + leachianone G = diphosphate + sophoraflavanone G
RHEA:10852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leachianone-G 2''-dimethylallyltransferase"
RHEA:10852	skos:prefLabel	"leachianone-G 2''-dimethylallyltransferase"
RHEA:10852	skos:altLabel	"leachianone G 2''-dimethylallyltransferase"
RHEA:35020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine(in) => L-threonine(out)
GO:0070456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose-1-phosphate phosphatase activity
REACT:R-MMU-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Mus musculus)
REACT:R-HSA-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Homo sapiens)
REACT:R-CFA-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Canis familiaris)
REACT:R-HSA-1369080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR binds STAT5 (Homo sapiens)
REACT:R-SSC-8944240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type III (Sus scrofa)
RHEA:25024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + riboflavin <=> CDP + FMN + H(+)
RHEA:41799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine
RHEA:29094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + 5 H(+)(in) + NADH <=> a ubiquinol + 4 H(+)(out) + NAD(+)
REACT:R-BTA-389622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Bos taurus)
RHEA:56614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + NAD(+)
REACT:R-GGA-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Gallus gallus)
REACT:R-HSA-3656230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective B4GALT1 does not transfer Gal to the keratan chain (Homo sapiens)
REACT:R-XTR-5685838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex binds D-loop structures (Xenopus tropicalis)
RHEA:41613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => D-ribose 2,5-bisphosphate + H(+)
GO:0043834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine methyltransferase activity
GO:0043834	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity
GO:0043834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMA methyltransferase 1
GO:0043834	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mttB1
GO:0043834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine:corrinoid methyltransferase activity
GO:0043834	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	MT1
REACT:R-BTA-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Bos taurus)
REACT:R-SSC-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Sus scrofa)
RHEA:29537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
REACT:R-HSA-8875183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates activated MET (Homo sapiens)
REACT:R-HSA-909720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN alpha/beta binds to IFNAR2 (Homo sapiens)
RHEA:47824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + octadecanoyl-[ACP] = 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-DRE-5654647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
REACT:R-HSA-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Homo sapiens)
REACT:R-CFA-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Canis familiaris)
RHEA:64089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA => 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O
RHEA:10264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose = beta-D-glucose
RHEA:70320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 3,4-bisphosphate + phosphate
REACT:R-SSC-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Sus scrofa)
GO:0008681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octaprenyl-6-methoxyphenol hydroxylase activity
RHEA:63544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kinetensin = kinetensin-(1-8) + L-leucine
REACT:R-CFA-8871226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA2 (Canis familiaris)
REACT:R-MMU-202709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 dimerises (Mus musculus)
REACT:R-DDI-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Dictyostelium discoideum)
REACT:R-BTA-2327695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Bos taurus)
REACT:R-RNO-390438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR2 reduces PalmCoA to HXOL (Rattus norvegicus)
GO:0051909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropenoate dehydratase activity
GO:0051909	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alkynoate hydratase activity
GO:0051909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate
GO:0051909	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetylenecarboxylate hydratase activity
GO:0051909	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetylenemonocarboxylate hydratase activity
RHEA:55323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]
REACT:R-XTR-9620456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sGC stimulators bind sGC:NO (Xenopus tropicalis)
REACT:R-SPO-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Schizosaccharomyces pombe)
REACT:R-DRE-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)
RHEA:10040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H2O = AMP + phosphate
RHEA:10040	skos:altLabel	"phosphoadenylate 3'-nucleotidase"
RHEA:10040	skos:altLabel	"DPNPase"
RHEA:10040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3'(2'),5'-bisphosphate nucleotidase"
RHEA:10040	skos:altLabel	"3'-phosphoadenylylsulfate 3'-phosphatase"
RHEA:10040	skos:altLabel	"3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase"
RHEA:10040	skos:prefLabel	"3'(2'),5'-bisphosphate nucleotidase"
RHEA:26009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate <=> beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP
GO:0061981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine
GO:0061981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynureninase activity
REACT:R-CEL-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Caenorhabditis elegans)
RHEA:45510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] => phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]
REACT:R-GGA-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Gallus gallus)
REACT:R-DRE-6814683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Danio rerio)
REACT:R-XTR-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)
GO:0047615	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	actinomycin lactonohydrolase activity
GO:0047615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actinomycin lactonase activity
REACT:R-DRE-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Danio rerio)
RHEA:14995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH
REACT:R-MMU-8937177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD binds ARNT (Mus musculus)
REACT:R-XTR-6805022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 binds the heterodimer of MDM2 and MDM4 (Xenopus tropicalis)
REACT:R-DME-4084982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Drosophila melanogaster)
REACT:R-XTR-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Xenopus tropicalis)
GO:0090415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxymethyl chlorophyll a reductase activity
REACT:R-MMU-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Mus musculus)
REACT:R-DME-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Drosophila melanogaster)
REACT:R-BTA-204871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb2 (Bos taurus)
GO:0050234	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-pyrazolylalaninase activity
GO:0050234	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine hydro-lyase (adding pyrazole)
GO:0050234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrazolylalanine synthase activity
GO:0050234	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]
REACT:R-SSC-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Sus scrofa)
REACT:R-RNO-5654655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PPTN11 (Rattus norvegicus)
RHEA:54528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate = D-ribose 5-phosphate
RHEA:58485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(acetyl)-sphing-4-enine => acetate + sphing-4-enine
REACT:R-DRE-5691507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPA deacetylates NAA to acetate and L-aspartate (Danio rerio)
RHEA:18865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrolipoyllysine-residue (2-methylpropanoyl)transferase"
RHEA:18865	skos:altLabel	"dihydrolipoyl transacylase"
RHEA:18865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA
RHEA:18865	skos:prefLabel	"dihydrolipoyllysine-residue (2-methylpropanoyl)transferase"
REACT:R-CEL-1606273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) (Caenorhabditis elegans)
RHEA:23778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-L-aspartate + ADP => ATP + L-aspartate
GO:1990890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	netrin receptor binding
REACT:R-SPO-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Schizosaccharomyces pombe)
RHEA:14575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate + H2O => D-glucarate
RHEA:38853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetracenomycin F1 => H(+) + tetracenomycin F2
REACT:R-RNO-8944242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVII (Rattus norvegicus)
REACT:R-CFA-3296304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR31 is a receptor for 12(S)-HETE (Canis familiaris)
REACT:R-GGA-353265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB (Gallus gallus)
RHEA:28508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+) => alpha-Kdo-(2->6)-lipid IVA + ATP
REACT:R-HSA-9009065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)
RHEA:66079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminopentanoate
RHEA:20703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + lipid A disaccharide (E. coli) <=> ADP + H(+) + lipid IVA (E. coli)
REACT:R-CFA-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Canis familiaris)
REACT:R-SSC-3451153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits TRRAP/KAT5 HAT components (Sus scrofa)
RHEA:36780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + GDP-alpha-D-perosamine => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate
REACT:R-CEL-5671763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates PPP1R14A (Caenorhabditis elegans)
REACT:R-HSA-6785607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCM binds FAAP24 (Homo sapiens)
RHEA:46768	skos:prefLabel	"sn-2 palmitoyl-lipid 9-desaturase"
RHEA:46768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sn-2 palmitoyl-lipid 9-desaturase"
RHEA:46768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-74885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCYs converts GTP to cGMP (Bos taurus)
REACT:R-MMU-182993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL) (Mus musculus)
REACT:R-HSA-3814820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Homo sapiens)
RHEA:41391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate
REACT:R-DRE-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Danio rerio)
REACT:R-SSC-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Sus scrofa)
RHEA:28162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + GTP = CMP + GDP + H(+)
REACT:R-MMU-5654620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)
RHEA:16641	skos:altLabel	"FAEES"
RHEA:16641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl ethyl ester + H2O = a long-chain fatty acid + ethanol + H(+)
RHEA:16641	skos:prefLabel	"fatty-acyl-ethyl-ester synthase"
RHEA:16641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty-acyl-ethyl-ester synthase"
RHEA:16641	skos:altLabel	"FAEE synthase"
RHEA:42337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:2001065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannoglycan binding
GO:2001065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannan binding
RHEA:38670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine 1-phosphate(in) <=> sphing-4-enine 1-phosphate(out)
RHEA:44996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + acetoacetyl-CoA = CoA + O-3-oxobutanoyl-(R)-carnitine
REACT:R-GGA-9750942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP14 deubiquitinates NLRC5 (Gallus gallus)
REACT:R-RNO-5607740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta phosphorylates CARD9 (Rattus norvegicus)
REACT:R-DRE-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Danio rerio)
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methionine sulfoxide reductase B activity
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	selenoprotein R
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PilB
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pMSR
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-methionine (R)-S-oxide reductase activity
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MsrB
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SelR
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methionine sulfoxide reductase activity
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methionine S-oxide reductase activity
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine S-oxide reductase (R-form oxidizing) activity
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-methionine-R-oxide reductase activity
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SelX
GO:0033743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pMRsr
REACT:R-MMU-6788385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of ATR and ATRIP is recruited to ICL-DNA (Mus musculus)
RHEA:12422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => ATP + D-tagatofuranose 6-phosphate
REACT:R-CFA-109671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Canis familiaris)
REACT:R-SPO-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Schizosaccharomyces pombe)
REACT:R-HSA-5660694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol (Homo sapiens)
RHEA:62294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)
GO:0052855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-dependent H(4)NAD(P)OH dehydratase activity
GO:0052855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-dependent H4NAD(P)OH dehydratase activity
GO:0052855	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	reduced nicotinamide adenine dinucleotide hydrate dehydratase activity
GO:0052855	skos:altLabel	"(6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolyzing; NADH-forming)"
GO:0052855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-dependent NAD(P)H-hydrate dehydratase"
GO:0052855	skos:prefLabel	"ADP-dependent NAD(P)H-hydrate dehydratase"
GO:0052855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-dependent NAD(P)H-hydrate dehydratase activity
GO:0052855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)
GO:0052855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing; NADH-forming)
GO:0052855	skos:altLabel	"(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolyzing)"
REACT:R-HSA-6798345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA (Homo sapiens)
REACT:R-RNO-2130478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of invariant chain trimer and MHC II alpha beta dimer (Rattus norvegicus)
RHEA:39683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)
REACT:R-RNO-6786124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3,STAT6 bind p-Y-IL4R (Rattus norvegicus)
REACT:R-HSA-3900070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MKL1 with SUMO1 (Homo sapiens)
GO:0047759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal dehydrogenase activity
GO:0047759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butanal:NAD(P)+ oxidoreductase (CoA-acylating)
GO:0070001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic-type peptidase activity
RHEA:64338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA => H(+) + 2 malonyl-CoA + nicotinyl-CoA
REACT:R-CFA-8875443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates LRIG1 (Canis familiaris)
RHEA:21931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + NADP(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADPH
REACT:R-SSC-5688276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT4 transfers ADPRib to GLUD (Sus scrofa)
REACT:R-CEL-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein(aspartate)methyltransferase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine:protein-carboxyl O-methyltransferase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MCP methyltransferase I
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein glutamate O-methyltransferase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein carboxyl-methylase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein methylase II
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein(carboxyl)methyltransferase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine-glutamyl methyltransferase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glutamate O-methyltransferase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methyl-accepting chemotaxis protein O-methyltransferase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein O-methyltransferase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein glutamate O-methylase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein carboxymethyltransferase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MCP methyltransferase II
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein carboxymethylase activity
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methyl-accepting chemotaxis protein methyltransferase II
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein carboxylmethyltransferase II
GO:0008983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein carboxyl-O-methyltransferase activity
RHEA:17750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinoline => AH2 + quinolin-2(1H)-one
RHEA:55356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol = 13-cis-retinol
RHEA:52595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholoyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH
REACT:R-BTA-8876616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND6A,B exchange GTP for GDP on RAB14 (Bos taurus)
RHEA:13449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH
RHEA:29183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + 2 O2 = 2 H(+) + menaquinone-8 + 2 superoxide
REACT:R-HSA-69891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)
RHEA:10517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) => (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH
REACT:R-DDI-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Dictyostelium discoideum)
RHEA:14862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + NADP(+) => H(+) + NADPH + orotate
REACT:R-HSA-8932037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and ESR1 bind the KCTD6 gene enhancer (Homo sapiens)
REACT:R-MMU-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Mus musculus)
RHEA:39223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctacosanoyl-CoA = (2E)-octacosenoyl-CoA + H2O
RHEA:65729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + hexyl sulfate + O2 => CO2 + H(+) + hexanal + succinate + sulfate
REACT:R-MMU-383363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 2 (NK2) binds to nuerokinin A (Mus musculus)
REACT:R-SSC-420584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin 3 trans heterodimer interaction (Sus scrofa)
RHEA:61403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-ribulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine
RHEA:68739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] <=> ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]
GO:0016432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity
GO:0016432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-uridine aminocarboxypropyltransferase activity
REACT:R-HSA-9013004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the ER membrane (Homo sapiens)
RHEA:47149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + caffeine + H2O => 1,3,7-trimethylurate + a ubiquinol
RHEA:56499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-9633044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR binds STRN (Rattus norvegicus)
REACT:R-HSA-9679775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT binds COMT Inhibitors (Homo sapiens)
REACT:R-DRE-176474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Danio rerio)
RHEA:36308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + H2O => 3,4-dihydroxybenzaldehyde + acetyl-CoA
REACT:R-DME-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Drosophila melanogaster)
RHEA:63837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + O2 => (2R)-2-hydroperoxyhexadecanoate
RHEA:38192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone => 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:63126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine + octadecanoate => H2O + N-octadecanoyl ethanolamine
RHEA:45335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin + O2 <=> 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)
RHEA:58327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine
REACT:R-RNO-2484822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore assembly (Rattus norvegicus)
REACT:R-HSA-3229089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
REACT:R-RNO-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Rattus norvegicus)
GO:0097100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	supercoiled DNA binding
REACT:R-BTA-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Bos taurus)
REACT:R-SSC-193995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 18-hydroxylates CORST to 18HCORST (Sus scrofa)
REACT:R-HSA-1602377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Homo sapiens)
REACT:R-MMU-1855153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Mus musculus)
REACT:R-HSA-9626038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF1A1 binds GTP (Homo sapiens)
REACT:R-GGA-210277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-1 (Gallus gallus)
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen/potassium-exchanging ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen:potassium-exchanging ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gastric H+/K+ ATPase
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H+/K+-ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gastric H+/K(+) ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP phosphohydrolase (H+/K+-exchanging)
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type potassium:proton transporter activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(K+ + H+)-ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen:potassium exchanging ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H,K-ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	proton pump activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H+/K(+)-exchanging ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H+-K+-ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H+/K+-exchanging ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	H+/K(+)-ATPase activity
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP12A:ATP4B exchanges K+ for H+ (Homo sapiens)
GO:0008900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	potassium:proton exchanging ATPase activity
REACT:R-SPO-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Schizosaccharomyces pombe)
RHEA:31288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA => acryloyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-CEL-77271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Caenorhabditis elegans)
REACT:R-CFA-3095889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC dealkylates RCbl (Canis familiaris)
REACT:R-DME-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Drosophila melanogaster)
REACT:R-SCE-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Saccharomyces cerevisiae)
REACT:R-DRE-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Danio rerio)
RHEA:32757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin + CO2 + H(+) + H2O + succinate => (2S)-naringenin + 2-oxoglutarate + O2
REACT:R-CFA-8854899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Canis familiaris)
RHEA:52507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"albonoursin synthase"
RHEA:35531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-phenylalanyl-L-leucyl) + 2 O2 = albonoursin + 2 H2O2
RHEA:35531	skos:prefLabel	"albonoursin synthase"
RHEA:35531	skos:altLabel	"cyclic dipeptide oxidase"
REACT:R-DME-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)
RHEA:56817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine ribonucleoside + H2O => a pyrimidine nucleobase + D-ribose
GO:0031711	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bradykinin receptor ligand
GO:0031711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bradykinin receptor binding
REACT:R-XTR-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Xenopus tropicalis)
REACT:R-CFA-444208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLNR (GPR38) is a receptor for motilin (Canis familiaris)
RHEA:37945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
REACT:R-HSA-1234183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Homo sapiens)
REACT:R-HSA-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)
REACT:R-MMU-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)
RHEA:15683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+)
REACT:R-CFA-5229111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 transports APP from trans-Golgi network to endosome lumen (Canis familiaris)
REACT:R-HSA-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Homo sapiens)
GO:0005345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine transmembrane transporter activity
GO:0005345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine nucleobase transmembrane transporter activity
GO:0005345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine base transmembrane transporter activity
REACT:R-XTR-548815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Xenopus tropicalis)
REACT:R-SCE-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Saccharomyces cerevisiae)
RHEA:36678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octacosanoyl)-sphinganine
REACT:R-CFA-936563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of DDX58 (Canis familiaris)
RHEA:49263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-galactose 6-phosphate(in) + L-histidyl-[protein]
RHEA:20614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine
REACT:R-XTR-5682863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF168 binds DNA DSBs (Xenopus tropicalis)
RHEA:59200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + docosanoate + H(+) = diphosphate + docosanoyl-AMP
REACT:R-CEL-8874201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L3 (Caenorhabditis elegans)
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor activity, G-protein coupled
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	orphan G protein coupled receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G-protein coupled receptor activity, unknown ligand
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	super conserved receptor expressed in brain receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	orphan GPCR activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SREB receptor
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein linked receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	orphan G-protein coupled receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RDC1 receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein linked receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Epstein-Barr Virus-induced receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Mas proto-oncogene receptor activity
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	EBV-induced receptor
GO:0004930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-dependent GPCR activity
RHEA:66691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 <=> (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O
RHEA:56522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine => Fe-coproporphyrin III + 2 S-adenosyl-L-methionine
REACT:R-BTA-5649673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyA from damaged DNA (Bos taurus)
REACT:R-DME-210881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Tie2/Ang1 complex (Drosophila melanogaster)
REACT:R-CFA-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Canis familiaris)
REACT:R-XTR-5682101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Xenopus tropicalis)
REACT:R-DRE-2404195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Danio rerio)
RHEA:65357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
REACT:R-HSA-9007860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds TWIST1,(TWIST2) (Homo sapiens)
RHEA:29119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + nitrate = a ubiquinone + H2O + nitrite
REACT:R-GGA-2173317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3a anaphylatoxin binds C3a receptor (Gallus gallus)
REACT:R-RNO-3928617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB2 binds KALRN (Rattus norvegicus)
RHEA:20400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + O-succinyl-L-homoserine <=> H(+) + L,L-cystathionine + succinate
REACT:R-XTR-9630923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B inhibitor binds NF-kappa-B complex (Xenopus tropicalis)
REACT:R-PFA-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Plasmodium falciparum)
REACT:R-DRE-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Danio rerio)
REACT:R-CEL-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Caenorhabditis elegans)
REACT:R-HSA-2172433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIX degradation (Homo sapiens)
REACT:R-DRE-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Danio rerio)
RHEA:57342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-L-kynurenine + S-adenosyl-L-methionine
GO:0080077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
REACT:R-DRE-5623521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A (Danio rerio)
RHEA:16503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + myo-inositol + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-1D-myo-inositol
RHEA:60721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hept-2-enal + H2O + NADP(+) => (E)-hept-2-enoate + 2 H(+) + NADPH
RHEA:21197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine => L-methionine + tetrahydropteroyltri-L-glutamate
REACT:R-HSA-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-CFA-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)
RHEA:66045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + H2O + kynurenate
REACT:R-BTA-3222072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAXX binds Ub-MDM2 and USP7 (Bos taurus)
RHEA:32297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 diphosphate + NADP(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH
RHEA:39091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenedioyl-CoA + H2O = (3S)-hydroxydecanedioyl-CoA
RHEA:19174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + naphthalene + O2 => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)
RHEA:63450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-(2-aminoethyl)phosphonate + diphosphate => (2-aminoethyl)phosphonate + CTP
REACT:R-MMU-2993447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6x(PCCA:PCCB) (Mus musculus)
REACT:R-CFA-4167509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial BTD hydrolyses BCTN (Canis familiaris)
EC:1.3.1.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-santonin 1,2-reductase"
EC:1.3.1.47	skos:prefLabel	"alpha-santonin 1,2-reductase"
RHEA:70166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + methotrexate(in) <=> H(+)(out) + methotrexate(out)
RHEA:64972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP + H2O = dUMP + H(+) + phosphate
REACT:R-PFA-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Plasmodium falciparum)
RHEA:15918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldopyranose + NAD(+) => aldono-1,5-lactone + H(+) + NADH
REACT:R-RNO-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Rattus norvegicus)
GO:0033885	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dihydroxy fatty acid phosphatase activity
GO:0033885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity
GO:0033885	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lipid-phosphate phosphatase activity
GO:0033885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
GO:0033885	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxy lipid phosphatase activity
GO:0033885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	soluble epoxide hydrolase activity
GO:0033885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sEH
GO:0033885	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxy fatty acid phosphatase activity
GO:0033885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
REACT:R-RNO-9756156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes ATV to ATVL (Rattus norvegicus)
RHEA:66984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + H2O = CoA + H(+) + isovalerate
RHEA:19130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thymidine => ADP + dTMP + H(+)
RHEA:30992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:13352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonate + S-adenosyl-L-methionine <=> methyl (-)-jasmonate + S-adenosyl-L-homocysteine
REACT:R-BTA-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Bos taurus)
REACT:R-DRE-2314686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS2 (Danio rerio)
REACT:R-HSA-428533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of CDC42 (Homo sapiens)
RHEA:63985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine + ATP => 5-hydroxyuridine 5'-phosphate + ADP + H(+)
REACT:R-CFA-1234159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)
RHEA:62299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) <=> (+)-malbrancheamide + 2 FADH2
REACT:R-HSA-9026007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Homo sapiens)
RHEA:13488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + S-(4-bromophenyl)-L-cysteine <=> 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate
RHEA:20268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-proline + O2 <=> cis-3-hydroxy-L-proline + CO2 + succinate
REACT:R-DME-1482689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)
REACT:R-DRE-2032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ), TBX5, and PCAF form a complex (Danio rerio)
RHEA:37960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-DME-450387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds the CRM1 nuclear export machinery (Drosophila melanogaster)
REACT:R-SSC-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Sus scrofa)
RHEA:32821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromate(out) => chromate(in)
REACT:R-RNO-9749647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES2 hydrolyzes ASA- (Rattus norvegicus)
REACT:R-XTR-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Xenopus tropicalis)
REACT:R-HSA-9007615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds RBBP8 gene promoter (Homo sapiens)
REACT:R-HSA-5617864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXD4 mRNA is translated (Homo sapiens)
RHEA:70760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
RHEA:58460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphocholine = a monoacyl-sn-glycero-3-phosphocholine + CoA
REACT:R-DRE-9708517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Danio rerio)
REACT:R-GGA-205231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of KIT upon SCF binding (Gallus gallus)
RHEA:69344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-but-1-en-1-SO-peroxol = (Z)-butanethial oxide
REACT:R-SCE-1482771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Saccharomyces cerevisiae)
RHEA:20488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-6785342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Danio rerio)
REACT:R-MMU-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Mus musculus)
REACT:R-CFA-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)
REACT:R-CFA-936963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization (Canis familiaris)
REACT:R-DRE-77321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Danio rerio)
RHEA:45053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + (R)-carnitine => CoA + O-(2E)-butenoyl-(R)-carnitine
GO:0018490	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
GO:0018490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylpyruvate oxidase activity
RHEA:55706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide => glycine + hydrogen sulfide + NAD(+)
RHEA:51791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-5'-AMP + CoA <=> 2-hydroxybenzoyl-CoA + AMP + H(+)
RHEA:70086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyclavatol <=> H2O + o-quinone methide
REACT:R-DME-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Drosophila melanogaster)
GO:0051379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenaline binding
GO:0051379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epinephrine binding
RHEA:38164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
GO:0031776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melanin-concentrating hormone receptor binding
GO:0031776	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	melanin-concentrating hormone receptor ligand
REACT:R-PFA-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Plasmodium falciparum)
REACT:R-SSC-5218952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)
REACT:R-HSA-977359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to membrane-associated Factor H:C3b (Homo sapiens)
REACT:R-MMU-977301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histidine is decarboxylated to histamine (Mus musculus)
REACT:R-HSA-9032502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FYN (Homo sapiens)
RHEA:22833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formimidoyl-L-glutamate => N-formyl-L-glutamate + NH4(+)
REACT:R-SCE-508179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Saccharomyces cerevisiae)
REACT:R-HSA-8849157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
REACT:R-BTA-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Bos taurus)
RHEA:22351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminoimidazole + H(+) + H2O <=> imidazol-4-one + NH4(+)
REACT:R-DME-198613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates p21Cip1 and p27Kip1 (Drosophila melanogaster)
RHEA:36193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline
REACT:R-SSC-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Sus scrofa)
RHEA:15322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:43496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonate + NAD(+) = H(+) + keto-D-fructuronate + NADH
RHEA:43496	skos:prefLabel	"L-gulonate 5-dehydrogenase"
RHEA:43496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-gulonate 5-dehydrogenase"
REACT:R-BTA-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Bos taurus)
RHEA:48856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O
RHEA:61647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine <=> 2 Fe(III)-[cytochrome b5] + H2O + L-arginine
REACT:R-SSC-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Sus scrofa)
REACT:R-HSA-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Homo sapiens)
RHEA:36510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetracosanoyl-CoA + CO2 + CoA
REACT:R-HSA-390438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR2 reduces PalmCoA to HXOL (Homo sapiens)
RHEA:72600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-aspartyl-L-glutamate(out) => N-acetyl-L-aspartyl-L-glutamate(in)
REACT:R-MMU-417843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y13 binds ADP (Mus musculus)
RHEA:67270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sch 210972 => (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate
REACT:R-DRE-156661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Exon Junction Complex (Danio rerio)
EC:3.5.1.1	skos:altLabel	"L-asparaginase"
EC:3.5.1.1	skos:prefLabel	"asparaginase"
EC:3.5.1.1	skos:altLabel	"L-asparagine amidohydrolase"
EC:3.5.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"asparaginase"
RHEA:12876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoate + NADP(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADPH
RHEA:56150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanoyl-sn-glycero-3-phosphocholine => hexadecanoyl-CoA + sn-glycerol 3-phosphocholine
REACT:R-DDI-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Dictyostelium discoideum)
RHEA:60346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine
REACT:R-BTA-8937631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Bos taurus)
REACT:R-GGA-420598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:Nectin-4 trans heterodimer formation (Gallus gallus)
RHEA:49011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADPH + O2 <=> aurachin C epoxide + H2O + NADP(+)
RHEA:13143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA => 2-methylpropanoyl-CoA
REACT:R-BTA-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Bos taurus)
REACT:R-PFA-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Plasmodium falciparum)
REACT:R-MMU-5686587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates RAD52 (Mus musculus)
REACT:R-BTA-5610746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI3 (Bos taurus)
REACT:R-DRE-6803761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Danio rerio)
REACT:R-MMU-2750187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Mus musculus)
RHEA:44096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decan-1-ol + hexadecanoyl-CoA = CoA + decanyl hexadecanoate
REACT:R-SPO-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Schizosaccharomyces pombe)
RHEA:64053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine => CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine
RHEA:35321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octadecanoyl-CoA
REACT:R-HSA-140221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transactivation of BBC3 (PUMA) by E2F1 (Homo sapiens)
GO:0043876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DtaAS
GO:0043876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-TA
GO:0043876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allo-TA
GO:0043876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	low-specificity D-threonine aldolase
GO:0043876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allo-threonine aldolase activity
GO:0043876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threonine aldolase activity
REACT:R-RNO-114256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS:APAF1 binds procaspase-9 (Rattus norvegicus)
REACT:R-DRE-433131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC1 co-transports dicarboxylic acids and a sodium ion (Danio rerio)
RHEA:56187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + UDP-alpha-D-galactose <=> globoside NOR1 + H(+) + UDP
RHEA:47283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6797962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMGLY translocates from cytosol to mitochondrial matrix (Homo sapiens)
REACT:R-MMU-5218839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
RHEA:12612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mercaptopurine + S-adenosyl-L-methionine <=> 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine
GO:0015486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoside-pentoside-hexuronide:cation symporter activity
RHEA:12115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + S-adenosyl-L-methionine <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine
RHEA:64506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine => AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine
REACT:R-XTR-373342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3CR1 binds CX3CL1 (Xenopus tropicalis)
REACT:R-SSC-380455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CDK11p58 to the centrosomes (Sus scrofa)
GO:0047855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrobunolol dehydrogenase activity
GO:0047855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bunolol reductase activity
GO:0047855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH
GO:0047855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrobunolol dehydrogenase"
GO:0047855	skos:altLabel	"bunolol reductase"
GO:0047855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity
GO:0047855	skos:prefLabel	"dihydrobunolol dehydrogenase"
RHEA:18078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[dinitrogen reductase] + NAD(+) => H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide
RHEA:22201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-aconitate => (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine
RHEA:64586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate(in) + Na(+)(in) => 2-hydroxyethane-1-sulfonate(out) + Na(+)(out)
REACT:R-MMU-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Mus musculus)
RHEA:27806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + acetyl-CoA = acetate + acetoacetyl-CoA
RHEA:38924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H(+) + Na(+)(in) + NADH => a ubiquinol + Na(+)(out) + NAD(+)
GO:0004304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estrogen sulphotransferase activity
GO:0004304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylylsulfate:oestrone sulfotransferase activity
GO:0004304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity
GO:0004304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oestrogen sulphotransferase activity
GO:0004304	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	estrogen sulfotransferase
GO:0004304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone sulfotransferase activity
GO:0004304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone sulphotransferase activity
GO:0004304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity
REACT:R-GGA-434097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viral dsRNA:TRL3:TICAM1 activates RIP1 (Gallus gallus)
REACT:R-GGA-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Gallus gallus)
RHEA:38181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone
RHEA:41269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoate + sphing-4-enine => H2O + N-(15Z-tetracosenoyl)-sphing-4-enine
RHEA:20221	skos:altLabel	"tetrahydrofolate formylase"
RHEA:20221	skos:prefLabel	"formate--tetrahydrofolate ligase"
RHEA:20221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate
RHEA:20221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate--tetrahydrofolate ligase"
RHEA:20221	skos:altLabel	"formyltetrahydrofolate synthetase"
RHEA:20221	skos:altLabel	"tetrahydrofolic formylase"
REACT:R-HSA-1989754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of APOA1 (Homo sapiens)
REACT:R-PFA-8848338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes TAG (Plasmodium falciparum)
RHEA:32712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH
REACT:R-DME-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Drosophila melanogaster)
RHEA:55428	skos:altLabel	"CYP76AH24"
RHEA:55428	skos:prefLabel	"ferruginol monooxygenase"
RHEA:55428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55428	skos:altLabel	"CYP76AH3"
RHEA:55428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferruginol monooxygenase"
REACT:R-BTA-9668023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to FVIII (Bos taurus)
REACT:R-HSA-1370500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR binds SCF beta-TrCP complex (Homo sapiens)
REACT:R-BTA-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Bos taurus)
REACT:R-BTA-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Bos taurus)
RHEA:27902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + caffeine + H2O = 1,3,7-trimethylurate + a ubiquinol
RHEA:27902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H2O + ubiquinone-0 = 1,3,7-trimethylurate + ubiquinol-0
RHEA:27902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caffeine dehydrogenase"
RHEA:27902	skos:prefLabel	"caffeine dehydrogenase"
RHEA:57434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase]
REACT:R-HSA-9757540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDN,PREDL diffuse into GI cells (Homo sapiens)
REACT:R-DME-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Drosophila melanogaster)
GO:0018563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
RHEA:48988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + O2 + rifampicin = 2'-N-hydroxyrifampicin + H2O + NAD(+)
REACT:R-HSA-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Homo sapiens)
REACT:R-HSA-1250486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers (Homo sapiens)
REACT:R-RNO-448603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33:IL1RL1 binds IL1RAP-1 (Rattus norvegicus)
RHEA:25612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-allofuranose <=> beta-D-allopyranose
RHEA:52696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP
RHEA:47072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoylglycerol + H2O = eicosanoate + glycerol + H(+)
REACT:R-GGA-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
RHEA:36200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine
REACT:R-GGA-140872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Gallus gallus)
RHEA:24001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] => a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]
RHEA:11734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B
RHEA:69582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + IMP => dGMP + inosine
RHEA:50564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]
REACT:R-XTR-202709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 dimerises (Xenopus tropicalis)
RHEA:61781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-tagatose => keto-L-sorbose
REACT:R-SPO-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Schizosaccharomyces pombe)
REACT:R-MMU-2161999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Mus musculus)
RHEA:63010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-octadecenoate + NH4(+) => (6Z)-octadecenamide + H2O
RHEA:32612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeranial + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH
REACT:R-XTR-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Xenopus tropicalis)
REACT:R-GGA-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Gallus gallus)
REACT:R-SSC-350901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is organified (Sus scrofa)
REACT:R-BTA-390598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Bos taurus)
REACT:R-DRE-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
RHEA:50332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:29317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + phosphate => alpha-D-galactose 1-phosphate + H2O
REACT:R-BTA-8956458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNLS:FAD oxidises dh-beta-NAD to NAD+ (Bos taurus)
RHEA:71003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)
REACT:R-XTR-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Xenopus tropicalis)
RHEA:25314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + O2 <=> glyoxylate + H2O2
REACT:R-CEL-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Caenorhabditis elegans)
REACT:R-GGA-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Gallus gallus)
REACT:R-RNO-2089927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Rattus norvegicus)
RHEA:12593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
RHEA:12593	skos:altLabel	"glycerophosphate phosphatidyltransferase"
RHEA:12593	skos:altLabel	"3-phosphatidyl-1'-glycerol-3'-phosphate synthase"
RHEA:12593	skos:prefLabel	"CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase"
RHEA:12593	skos:altLabel	"phosphatidylglycerophosphate synthase"
RHEA:12593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase"
RHEA:12593	skos:altLabel	"PGP synthase"
REACT:R-CFA-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Canis familiaris)
REACT:R-CFA-159803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Canis familiaris)
REACT:R-SSC-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)
RHEA:48577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorocatechol + O2 => 3-chloro-cis,cis-muconate + 2 H(+)
REACT:R-HSA-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Homo sapiens)
GO:0018423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-leucine O-methyltransferase activity
GO:0018423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein C-terminal leucine carboxyl O-methyltransferase activity
GO:0018423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Homo sapiens)
GO:0018423	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase methyltransferase activity
REACT:R-HSA-70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Homo sapiens)
REACT:R-RNO-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)
RHEA:52853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] => 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]
REACT:R-GGA-191784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA Cap hypermethylation (Gallus gallus)
RHEA:60041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate => (2E)-3-methylhex-2-enoate + L-glutamine
REACT:R-XTR-216045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I binds integrin alpha11beta1 (Xenopus tropicalis)
RHEA:40959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-SSC-352379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Sus scrofa)
REACT:R-XTR-173597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)
REACT:R-CFA-6810464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT14 hydrolyses UDP-Glc to G1P and UMP (Canis familiaris)
RHEA:72737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in) => UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out)
GO:0140862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone ubiquitin ligase activity (H2A-K119 specific)
GO:0140862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A-K119 ubiquitin ligase activity
GO:0140862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AK119 ubiquitin ligase activity
REACT:R-BTA-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Bos taurus)
REACT:R-HSA-5692941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACE1:GGA1,2,3 translocates from plasma membrane to endosome (Homo sapiens)
REACT:R-DDI-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Dictyostelium discoideum)
RHEA:23125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2R)-3-phosphoglycerate + 2 H(+) => CO2 + D-ribulose 1,5-bisphosphate + H2O
RHEA:28961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose(out) + H(+)(out) => D-xylose(in) + H(+)(in)
REACT:R-XTR-3149518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRR reduces cob(II)alamin to meCbl (Xenopus tropicalis)
REACT:R-HSA-1855227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)
RHEA:51378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoyl-dopamine => dopamine + hexadecanoyl-CoA
RHEA:49167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine
RHEA:19541	skos:prefLabel	"glutamate-5-semialdehyde dehydrogenase"
RHEA:19541	skos:altLabel	"Glutamyl-gamma-semialdehyde dehydrogenase"
RHEA:19541	skos:altLabel	"Gamma-glutamylphosphate reductase"
RHEA:19541	skos:altLabel	"beta-glutamylphosphate reductase"
RHEA:19541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH
RHEA:19541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate-5-semialdehyde dehydrogenase"
RHEA:61442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine => acetyl-CoA + S-(2-succino)-L-cysteine
REACT:R-MMU-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Mus musculus)
REACT:R-DRE-1606288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Danio rerio)
RHEA:18648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 putrescine <=> NH4(+) + sym-homospermidine
REACT:R-GGA-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Gallus gallus)
RHEA:41032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA
REACT:R-CFA-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Canis familiaris)
REACT:R-SSC-2168884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Methemoglobin to Hemopexin (Sus scrofa)
RHEA:50702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-1458875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT binds to FZD and LRP5/6 (Homo sapiens)
REACT:R-SSC-6809521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPIF binds bacteria (Sus scrofa)
REACT:R-HSA-9730521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 3a induces potassium efflux (Homo sapiens)
GO:0050111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycocerosate synthase activity
GO:0050111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)
GO:0050111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mycocerosic acid synthase activity
GO:0080108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-alkylthiohydroximate lyase activity
GO:0080108	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	S-alkylthiohydroximate C-S lyase activity
REACT:R-CFA-9038163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Canis familiaris)
RHEA:56759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:26033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-RNO-5218640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates p-Y397-PTK2 (Rattus norvegicus)
RHEA:43912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0102294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol dehydrogenase activity
REACT:R-SSC-446200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLPP1 dephosphorylates DOLDP to DOLP (Sus scrofa)
REACT:R-RNO-191654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-src associates with Cx43 in gap junctions (Rattus norvegicus)
RHEA:28429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allulose 6-phosphate <=> keto-D-fructose 6-phosphate
RHEA:65208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA + H2O = (S)-3-hydroxybutanoate + CoA + H(+)
REACT:R-DME-169828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex (Drosophila melanogaster)
RHEA:11339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine <=> deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-167181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to HIV-1 transcript elongation (Homo sapiens)
REACT:R-XTR-2294590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds phosphorylated condensin II complex (Xenopus tropicalis)
RHEA:38677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-SCE-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Saccharomyces cerevisiae)
REACT:R-SSC-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)
RHEA:42812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA
REACT:R-HSA-9624014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 (Homo sapiens)
RHEA:51713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagatose 6-phosphate => keto-D-fructose 6-phosphate
RHEA:29265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(out) + Na(+)(out) => L-leucine(in) + Na(+)(in)
REACT:R-DRE-4332359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active calmodulin binds CAMK2 (Danio rerio)
REACT:R-MMU-183126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to surface-associated C3b (Mus musculus)
REACT:R-MMU-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Mus musculus)
RHEA:29521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose
RHEA:57419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-asparaginyl-[protein] <=> L-aspartyl-[protein] + NH4(+)
REACT:R-DME-351913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of TJP1 (Drosophila melanogaster)
REACT:R-CFA-177923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sustained activation of SRC kinase by SHP2 (Canis familiaris)
RHEA:39235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytriacontanoyl-CoA = (2E)-triacontenoyl-CoA + H2O
REACT:R-CFA-3465459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Canis familiaris)
EC:1.14.13.147	skos:prefLabel	"taxoid 7beta-hydroxylase"
EC:1.14.13.147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taxoid 7beta-hydroxylase"
RHEA:54819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[protein] + L-lysyl-[protein] <=> [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)
REACT:R-XTR-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Xenopus tropicalis)
RHEA:69028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane-3alpha,17beta-diol + NADP(+)
REACT:R-BTA-174255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation multiubiquitinated Cyclin A (Bos taurus)
RHEA:12678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + Latia luciferin + 2 O2 => A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin
REACT:R-XTR-9731661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Xenopus tropicalis)
REACT:R-DRE-140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Danio rerio)
REACT:R-DME-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Drosophila melanogaster)
REACT:R-BTA-163214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)
REACT:R-DRE-378513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Danio rerio)
RHEA:46359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9700200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)
REACT:R-DRE-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Danio rerio)
REACT:R-XTR-5655466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Xenopus tropicalis)
RHEA:28737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + spermidine(in) => H(+)(in) + spermidine(out)
REACT:R-HSA-5358919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 exchanges ADP for ATP (Homo sapiens)
EC:1.3.99.12	skos:altLabel	"branched-chain acyl-CoA dehydrogenase"
EC:1.3.99.12	skos:prefLabel	"2-methylacyl-CoA dehydrogenase"
EC:1.3.99.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methylacyl-CoA dehydrogenase"
REACT:R-MMU-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Mus musculus)
RHEA:41611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha,alpha-trehalose <=> 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)
REACT:R-MMU-1236940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exogenous soluble antigen targeted to more stable early endosome (Mus musculus)
REACT:R-CEL-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Caenorhabditis elegans)
REACT:R-RNO-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Rattus norvegicus)
RHEA:40680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:72208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 hydrogencarbonate(in) => chloride(in) + 2 hydrogencarbonate(out)
REACT:R-BTA-5607759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIKA2 binds K63polyUb-TRAF6 oligomer (Bos taurus)
REACT:R-GGA-202510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1-TAB2 complex (Gallus gallus)
REACT:R-RNO-8851436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFHR dimers bind C3b (Rattus norvegicus)
REACT:R-RNO-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Rattus norvegicus)
REACT:R-XTR-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Xenopus tropicalis)
RHEA:17740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADPH
REACT:R-BTA-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Bos taurus)
REACT:R-MMU-9731924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds EDNs (Mus musculus)
REACT:R-CFA-5660662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASC binds Caspase-8 complex (Canis familiaris)
REACT:R-GGA-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Gallus gallus)
REACT:R-MMU-8954262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Mus musculus)
REACT:R-MMU-4720446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Mus musculus)
REACT:R-DRE-174427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Danio rerio)
REACT:R-DRE-917892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-1 transports heme from cytosol to extracellular region (Danio rerio)
REACT:R-CFA-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Canis familiaris)
REACT:R-MMU-9645428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 binds ADP-heptose (Mus musculus)
RHEA:11958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + D-glucose => cholesteryl 3-beta-D-glucoside + H2O
RHEA:41199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate
REACT:R-HSA-163551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triacylglycerol + H2O -> diacylglycerol + fatty acid (Homo sapiens)
REACT:R-HSA-5615637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Homo sapiens)
GO:0033855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAAT-I
GO:0033855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotianamine transaminase activity
GO:0033855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAAT
GO:0033855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotianamine aminotransferase activity
GO:0033855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotianamine:2-oxoglutarate aminotransferase activity
GO:0033855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAAT-II
GO:0033855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAAT-III
REACT:R-XTR-216050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Xenopus tropicalis)
REACT:R-RNO-2029460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates LIMK1 (Rattus norvegicus)
RHEA:36420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-2467798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTTG1 (Securin) sequesters ESPL1 (Separase) (Sus scrofa)
RHEA:30416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 NADPH + O2 + octadecanal => formate + H2O + heptadecane + 2 NADP(+)
GO:0097371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2/MDM4 family protein binding
REACT:R-HSA-2220978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXW7 WD mutants do not bind NICD1 (Homo sapiens)
RHEA:17040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-ethanol + NADP(+) <=> H(+) + indole-3-acetaldehyde + NADPH
GO:0032399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HECT domain binding
REACT:R-GGA-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Gallus gallus)
REACT:R-CFA-5218832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds PAK2 (Canis familiaris)
RHEA:32309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene A4 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-CFA-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Canis familiaris)
REACT:R-BTA-2179387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Bos taurus)
REACT:R-HSA-354165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GO:0018655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity
RHEA:20313	skos:altLabel	"IP5 2-kinase"
RHEA:20313	skos:altLabel	"inositol polyphosphate kinase"
RHEA:20313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)
RHEA:20313	skos:prefLabel	"inositol-pentakisphosphate 2-kinase"
RHEA:20313	skos:altLabel	"inositol 1,3,4,5,6-pentakisphosphate 2-kinase"
RHEA:20313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-pentakisphosphate 2-kinase"
RHEA:20313	skos:altLabel	"Ins(1,3,4,5,6)P5 2-kinase"
RHEA:23353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-aminobutanoate => L-glutamate + succinate semialdehyde
RHEA:53587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D2 <=> 7-oxoresolvin D2 + H(+) + NADH
RHEA:62285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + L-proline + L-tryptophan + NADPH => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)
REACT:R-RNO-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Rattus norvegicus)
RHEA:54347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-SSC-6804402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F1 (Sus scrofa)
REACT:R-BTA-5626953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds DENN/MADD (Bos taurus)
REACT:R-CFA-2176445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD2 (Canis familiaris)
REACT:R-MMU-2168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds DLL4 (Mus musculus)
RHEA:14499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + isopyridoxal => A + pyridoxine
REACT:R-GGA-3451153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits TRRAP/KAT5 HAT components (Gallus gallus)
RHEA:51457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-isoleucine => (9Z)-octadecenoate + L-isoleucine
GO:0004540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease activity
RHEA:10710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GDP-D-glucose => alpha-D-glucose 1-phosphate + GTP + H(+)
RHEA:28530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XMP = phosphate + xanthosine
REACT:R-HSA-182993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL) (Homo sapiens)
REACT:R-RNO-708349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD2 oligomerizes (Rattus norvegicus)
RHEA:57290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O
REACT:R-SCE-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Saccharomyces cerevisiae)
REACT:R-BTA-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Bos taurus)
RHEA:20808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O-acetylneuraminate
RHEA:18500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ribulose 5-phosphate <=> L-xylulose 5-phosphate
REACT:R-HSA-2321904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN mRNA translation negatively regulated by microRNAs (Homo sapiens)
REACT:R-HSA-9731057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 3a binds to caspase-1 (Homo sapiens)
RHEA:36096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + salicylate => methyl salicylate + S-adenosyl-L-homocysteine
REACT:R-XTR-388809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTLA-4 binds B7-1/B7-2 (Xenopus tropicalis)
REACT:R-GGA-202727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaMbeta2 (MAC1) binds JAM3 (Gallus gallus)
RHEA:16298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH
REACT:R-RNO-936380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PIN1 with p-IRF3 (Rattus norvegicus)
REACT:R-CEL-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Caenorhabditis elegans)
GO:0055054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose:hydrogen symporter activity
GO:0055054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose:proton symporter activity
RHEA:49623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythritol 1-phosphate + NADP(+) <=> D-erythrulose 1-phosphate + H(+) + NADPH
REACT:R-DME-182990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty sequesters CBL away from active EGFR (Drosophila melanogaster)
REACT:R-CEL-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Caenorhabditis elegans)
REACT:R-SPO-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Schizosaccharomyces pombe)
RHEA:51151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + 2 oxidized [azurin] <=> an aldehyde + 2 H(+) + 2 reduced [azurin]
REACT:R-SSC-203130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OLR1 binds to oxidized LDL (Sus scrofa)
RHEA:51051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + A <=> AH2 + androst-4-ene-3,17-dione
RHEA:20235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-oxosteroid + H(+) + NADPH => a 7beta-hydroxysteroid + NADP(+)
GO:0052659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type II inositol polyphosphate 5-phosphatase activity
GO:0052659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5PTase activity
GO:0052659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ins(1,3,4,5)P4 5-phosphatase activity
GO:0052659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0052659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type I inositol-polyphosphate phosphatase activity
GO:0052659	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol polyphosphate-5-phosphatase activity
GO:0052659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ins(1,3,4,5)P(4) 5-phosphatase activity
GO:0052659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-myo-inositol (1,3,4,5)-polyphosphate 5-phosphatase activity
RHEA:49792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + glycine = CoA + H(+) + N-eicosanoylglycinate
REACT:R-DRE-110221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by SMUG1 glycosylase (Danio rerio)
REACT:R-RNO-9020610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Rattus norvegicus)
REACT:R-RNO-109759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Rattus norvegicus)
REACT:R-BTA-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Bos taurus)
GO:0032027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin light chain binding
REACT:R-SSC-5659781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 forms a heterodimer with BARD1 (Sus scrofa)
GO:0019163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity
GO:0019163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine 5'-phosphate transaminase activity
GO:0019163	skos:altLabel	"Pyridoxamine-phosphate aminotransferase"
GO:0019163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + pyridoxamine 5'-phosphate = D-glutamate + pyridoxal 5'-phosphate
GO:0019163	skos:prefLabel	"pyridoxamine-phosphate transaminase"
GO:0019163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine-phosphate aminotransferase activity
GO:0019163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine phosphate aminotransferase activity
GO:0019163	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)
GO:0019163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine-phosphate transaminase activity
GO:0019163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxamine-phosphate transaminase"
REACT:R-GGA-352908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 6-phosphate + ATP => fructose 2,6-bisphosphate + ADP (Gallus gallus)
REACT:R-RNO-194017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 11DCORST to CORST (Rattus norvegicus)
REACT:R-SSC-8850786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK12 (Sus scrofa)
REACT:R-HSA-6806629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tonofilament bundles (Homo sapiens)
REACT:R-GGA-2859050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of C4b (Gallus gallus)
REACT:R-HSA-9700200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)
GO:0010283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pinoresinol reductase activity
RHEA:68531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> beta-bisabolene + diphosphate
REACT:R-HSA-9645428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 binds ADP-heptose (Homo sapiens)
REACT:R-GGA-8854466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds RELN (Gallus gallus)
REACT:R-PFA-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Plasmodium falciparum)
REACT:R-SSC-8850961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREX2 binds PTEN and inhibits it (Sus scrofa)
RHEA:54580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)
REACT:R-SCE-194678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 demethylates LNSOL (Saccharomyces cerevisiae)
REACT:R-XTR-8851954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GAB1 recruits PI3K to MET (Xenopus tropicalis)
RHEA:27839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-carbazole + H(+) + NADH + O2 => 2'-aminobiphenyl-2,3-diol + NAD(+)
REACT:R-CEL-6813740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDE1 hydrolyzes GroPIns (Caenorhabditis elegans)
REACT:R-HSA-5693561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)
REACT:R-CFA-198621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates caspase-9 (Canis familiaris)
REACT:R-HSA-2972979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), NANOG bind the CDX2 promoter (Homo sapiens)
REACT:R-CFA-9029667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DFF dissociates from importin-alpha:importin-beta (Canis familiaris)
REACT:R-BTA-450173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 induces oligomerisation of TRAF6 (Bos taurus)
GO:0015214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine nucleoside transmembrane transporter activity
RHEA:70111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:18880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + S-adenosyl-L-methionine <=> 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine
RHEA:13668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP <=> 3',5'-cyclic GMP + diphosphate
REACT:R-DDI-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Dictyostelium discoideum)
REACT:R-SSC-428007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled histidine and di-peptide cotransport (Sus scrofa)
RHEA:58076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(11Z-eicosenoyl)-glycerol + H2O = (11Z)-eicosenoate + glycerol + H(+)
REACT:R-CFA-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Canis familiaris)
RHEA:40651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)
RHEA:57191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] <=> glycolate + H(+) + L-arginyl-[protein]
REACT:R-MMU-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Mus musculus)
REACT:R-SSC-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Sus scrofa)
EC:2.7.4.25	skos:altLabel	"deoxycytidine monophosphokinase"
EC:2.7.4.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(d)CMP kinase"
EC:2.7.4.25	skos:altLabel	"dCMP kinase"
EC:2.7.4.25	skos:altLabel	"deoxycytidylate kinase"
EC:2.7.4.25	skos:prefLabel	"(d)CMP kinase"
RHEA:19034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-glucosamine => an N-acyl-D-mannosamine
RHEA:57893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + 5 H(+)(in) + NADPH => a quinol + 4 H(+)(out) + NADP(+)
GO:0070326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-low-density lipoprotein particle receptor binding
GO:0070326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-low-density lipoprotein receptor binding
GO:0070326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	apolipoprotein E receptor binding
GO:0070326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL receptor binding
GO:0070326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binding
REACT:R-BTA-6810357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fillagrin and keratin intermediate filaments polymerise forming a network (Bos taurus)
REACT:R-XTR-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Xenopus tropicalis)
RHEA:39862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol
REACT:R-MMU-183072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR non-clathrin mediated endocytosis (Mus musculus)
REACT:R-DRE-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Danio rerio)
RHEA:10518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH => (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+)
REACT:R-DRE-5578966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A:AGO2:miRNA is transported into the nucleus (Danio rerio)
REACT:R-DME-193508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)
REACT:R-HSA-2161732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXB2 is converted to 11dh-TXB2 by TXDH (Homo sapiens)
REACT:R-DRE-5357904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Danio rerio)
REACT:R-XTR-193401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
RHEA:53754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose
REACT:R-MMU-5692770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Mus musculus)
RHEA:36366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)
REACT:R-GGA-8943780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 recruits NuRD to PTEN gene (Gallus gallus)
REACT:R-RNO-444773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-TM7 receptors bind chondroitin sulphate (Rattus norvegicus)
GO:0071535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RING-like zinc finger domain binding
REACT:R-DRE-8938770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Danio rerio)
GO:0047487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligogalacturonide lyase activity
GO:0047487	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	unsaturated oligogalacturonate transeliminase activity
GO:0047487	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligogalacturonate lyase activity
GO:0047487	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OGTE
RHEA:54770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine
REACT:R-CFA-9026894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK2 (Canis familiaris)
REACT:R-MMU-389919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds pBTLA (Mus musculus)
REACT:R-GGA-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Gallus gallus)
RHEA:21348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetracenomycin F2 synthase"
RHEA:21348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + 10 malonyl-CoA = 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2
RHEA:21348	skos:prefLabel	"tetracenomycin F2 synthase"
GO:0103111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine PTS permease activity
RHEA:30358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + methane + O2 <=> a quinone + H2O + methanol
REACT:R-SPO-6791218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Schizosaccharomyces pombe)
REACT:R-XTR-191062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of Klotho-bound FGFR1c (Xenopus tropicalis)
REACT:R-MMU-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Mus musculus)
RHEA:47462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-dodecenoyl-CoA + acetyl-CoA => 3-oxo-(5Z-tetradecenoyl)-CoA + CoA
RHEA:18181	skos:prefLabel	"malate synthase"
RHEA:18181	skos:altLabel	"malic synthetase"
RHEA:18181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)
RHEA:18181	skos:altLabel	"malate condensing enzyme"
RHEA:18181	skos:altLabel	"malic-condensing enzyme"
RHEA:18181	skos:altLabel	"glyoxylic transacetase"
RHEA:18181	skos:altLabel	"glyoxylate transacetase"
RHEA:18181	skos:altLabel	"L-malate glyoxylate-lyase (CoA-acetylating)"
RHEA:18181	skos:altLabel	"glyoxylate transacetylase"
RHEA:18181	skos:altLabel	"malate synthetase"
RHEA:18181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malate synthase"
REACT:R-HSA-9677917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA inhibitors bind MAOA:FAD (Homo sapiens)
REACT:R-DRE-2066778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Danio rerio)
REACT:R-DRE-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Danio rerio)
RHEA:11984	skos:prefLabel	"progesterone monooxygenase"
RHEA:11984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + progesterone = A + H2O + testosterone acetate
RHEA:11984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"progesterone monooxygenase"
RHEA:11984	skos:altLabel	"progesterone hydroxylase"
RHEA:72021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + H2O + succinate + trihazone D => 2-oxoglutarate + H(+) + O2 + trihazone A
RHEA:66042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-HSA-158145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Homo sapiens)
REACT:R-DME-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Drosophila melanogaster)
GO:0004527	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	exonuclease IX activity
GO:0004527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exonuclease activity
RHEA:54311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine
REACT:R-HSA-9694539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp15 binds nsp8 (Homo sapiens)
RHEA:22992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH
RHEA:46857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
GO:0047473	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-alanine:poly(phosphoribitol) ligase (AMP-forming)
GO:0047473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanine-D-alanyl carrier protein ligase activity
GO:0047473	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-alanine-poly(phosphoribitol) ligase activity
GO:0047473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine [D-alanyl carrier protein] ligase activity
GO:0047473	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanine-activating enzyme activity
RHEA:68655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-homocysteine <=> H(+) + hydrogen sulfide + L-homolanthionine
REACT:R-DRE-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Danio rerio)
RHEA:68340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate
GO:0050218	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propanoate:CoA ligase (AMP-forming)
GO:0050218	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propionyl-CoA synthetase activity
GO:0050218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionate-CoA ligase activity
REACT:R-BTA-2396007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3 is phosphorylated by TBK1 (Bos taurus)
REACT:R-CEL-9614423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO1 (Caenorhabditis elegans)
REACT:R-CFA-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Canis familiaris)
RHEA:39061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-6784423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Bos taurus)
RHEA:71839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in)
RHEA:28246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pantoate kinase"
RHEA:28246	skos:prefLabel	"pantoate kinase"
RHEA:28246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)
REACT:R-DRE-870449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 monoubiquitinates SMAD4 (Danio rerio)
RHEA:15748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->1)-beta-D-fructosyl](n) + sucrose <=> [(2->1)-beta-D-fructosyl](n+1) + D-glucose
REACT:R-DRE-5671993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT-3 binds DLG4 (Danio rerio)
REACT:R-SCE-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Saccharomyces cerevisiae)
RHEA:70142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Sus scrofa)
GO:0043891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity
GO:0043891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity
GO:0043891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triosephosphate dehydrogenase (NAD(P))
GO:0043891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triosephosphate dehydrogenase (NAD(P)+)
GO:0043891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)
GO:0043891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)
REACT:R-MMU-6798257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRS binds NTRK3 (Mus musculus)
RHEA:17087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2 => 4-pyridoxate + A
REACT:R-DDI-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Dictyostelium discoideum)
REACT:R-DME-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)
RHEA:35895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
GO:0051745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity
GO:0051745	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity
GO:0051745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity
REACT:R-DRE-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Danio rerio)
RHEA:65568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine
REACT:R-DRE-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Danio rerio)
RHEA:42764	skos:altLabel	"coenzyme F420 reducing formate dehydrogenase"
RHEA:42764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:42764	skos:altLabel	"coenzyme F420-dependent formate dehydrogenase"
RHEA:42764	skos:prefLabel	"formate dehydrogenase (coenzyme F420)"
RHEA:42764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate dehydrogenase (coenzyme F420)"
REACT:R-HSA-9603991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Homo sapiens)
REACT:R-HSA-9700193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK mutants phosphorylate SHC1 (Homo sapiens)
REACT:R-SSC-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Sus scrofa)
REACT:R-CEL-418918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The UDP/CysLT (P2Y17) receptor can bind UTP (Caenorhabditis elegans)
RHEA:58769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)
RHEA:24421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-terminal N-formyl-L-methionyl-[peptide] => formate + N-terminal L-methionyl-[peptide]
RHEA:23902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-hydrobenzoin => cis-stilbene oxide + H2O
RHEA:38935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)"
RHEA:38935	skos:prefLabel	"cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)"
RHEA:38935	skos:altLabel	"cyclohexane-1-carbonyl-CoA dehydrogenase"
RHEA:38935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-CFA-8850777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK14 (Canis familiaris)
RHEA:66114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate => 2-oxobutanoate + L-tyrosine
REACT:R-CFA-8950757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Canis familiaris)
REACT:R-BTA-5635843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI translocates to the nucleus (Bos taurus)
REACT:R-PFA-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Plasmodium falciparum)
REACT:R-HSA-9618586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the promoter of the MYC gene (Homo sapiens)
REACT:R-DRE-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)
REACT:R-GGA-2396370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds collagens II, III and V (Gallus gallus)
RHEA:45893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + CDP-ethanolamine => an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)
REACT:R-CEL-3899291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of EP300 with SUMO1 (Caenorhabditis elegans)
RHEA:22596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cephalosporin C + H2O = acetate + deacetylcephalosporin C + H(+)
RHEA:22596	skos:prefLabel	"cephalosporin-C deacetylase"
RHEA:22596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cephalosporin-C deacetylase"
RHEA:47918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate => ATP + N-hexanoyl-(4R)-hydroxysphinganine
REACT:R-SPO-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)
RHEA:62730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide D + FADH2 => (+)-malbrancheamide B + bromide + FAD + 2 H(+)
REACT:R-HSA-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)
RHEA:64820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetamide + H2O = 2-phenylacetate + NH4(+)
REACT:R-HSA-1834939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING recruits TBK1 and IRF3 (Homo sapiens)
REACT:R-XTR-200424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Xenopus tropicalis)
RHEA:65202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O => S-(acetaldehyde)-L-cysteine
REACT:R-CEL-182969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:CBL) (Caenorhabditis elegans)
RHEA:38360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 => thiosulfate + ubiquinol-10
RHEA:38483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)
RHEA:50856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
RHEA:25154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-glutamate => 2-oxoglutarate + L-phenylalanine
RHEA:61087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + 2-oxoglutarate + O2 <=> (2R,3R)-dihydrokaempferol + CO2 + succinate
REACT:R-CFA-5218640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates p-Y397-PTK2 (Canis familiaris)
REACT:R-BTA-114600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Bos taurus)
RHEA:57301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + H(+) + lactate
RHEA:11438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O => 4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2
RHEA:17020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA <=> (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA
REACT:R-MMU-354165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
REACT:R-DRE-8851044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN1A1 binds xanthine oxidoreductase (XDH) (Danio rerio)
RHEA:67684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid(in) + ATP + H2O = a long-chain fatty acid(out) + ADP + H(+) + phosphate
RHEA:44613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-209125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Sus scrofa)
RHEA:32960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine + NAD(+) => (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)
REACT:R-BTA-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Bos taurus)
REACT:R-DME-9010872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 binds Dystroglycan (Drosophila melanogaster)
REACT:R-GGA-166041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of LPS onto TLR4 (Gallus gallus)
REACT:R-SSC-5607023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IXa associates with cell membrane (Sus scrofa)
REACT:R-SSC-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Sus scrofa)
RHEA:67707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate
REACT:R-CFA-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Canis familiaris)
REACT:R-SSC-9611277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds P2RY12 antagonists (Sus scrofa)
REACT:R-DRE-8983298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Danio rerio)
REACT:R-MMU-9690439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds LTC4,LTD4,LTE4 (Mus musculus)
REACT:R-CFA-69604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25A at Ser-123 by Chk1 (Canis familiaris)
REACT:R-CEL-3095889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC dealkylates RCbl (Caenorhabditis elegans)
RHEA:56454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-epi-hapalindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole
REACT:R-MMU-2197770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1 (FEEL-1) binds ligands (Mus musculus)
REACT:R-CFA-5694442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH2,3 bind GRIA1 (Canis familiaris)
REACT:R-CEL-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Caenorhabditis elegans)
RHEA:20398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + O-succinyl-L-homoserine => H(+) + L,L-cystathionine + succinate
REACT:R-HSA-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
REACT:R-MMU-1236958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of particulate antigens with dendritic cell receptors (Mus musculus)
GO:0102167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity
REACT:R-HSA-8952903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRHL2 hydrolyses poly(ADP-ribose) (Homo sapiens)
RHEA:36058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-amino-4-hydroxypteridine + H(+) + H2O <=> a 2,4-dihydroxypteridine + NH4(+)
GO:0086081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesive protein binding involved in atrial cardiomyocyte-atrioventricular node cell communication
GO:0086081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication
GO:0086081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cell adhesive protein binding involved in atrial cardiomyocyte-AV node cell communication
RHEA:55805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O => (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)
REACT:R-BTA-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Bos taurus)
REACT:R-RNO-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Rattus norvegicus)
REACT:R-RNO-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
RHEA:47138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + lithocholoyl-CoA => ATP + CoA + lithocholate
REACT:R-DRE-166817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by C3 convertases (Danio rerio)
REACT:R-RNO-2161768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXA4 is converted to EXC4 by LTC4S (Rattus norvegicus)
REACT:R-SSC-8854759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D14 binds RAB11 and ULK1 (Sus scrofa)
REACT:R-SCE-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Saccharomyces cerevisiae)
REACT:R-GGA-177927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to EGF:EGFR:GRB2:GAB1 (Gallus gallus)
REACT:R-SPO-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Schizosaccharomyces pombe)
REACT:R-DDI-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Dictyostelium discoideum)
REACT:R-DDI-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Dictyostelium discoideum)
REACT:R-SSC-437118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI stimulates PI3K beta, gamma (Sus scrofa)
RHEA:30389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + GDP + H(+) => GDP-alpha-D-glucose + phosphate
GO:0047052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)
GO:0047052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-stylopine synthase activity
GO:0047052	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity
RHEA:65298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylacryloyl-CoA + reduced [electron-transfer flavoprotein] => (2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-HSA-629588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)
RHEA:48602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein-PII]-L-tyrosine + H(+) + UMP => [protein-PII]-uridylyl-L-tyrosine + H2O
REACT:R-HSA-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Homo sapiens)
REACT:R-BTA-5656064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FLRT1,2,3 (Bos taurus)
RHEA:41870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-[ACP] + CO2 + holo-[ACP] => decanoyl-[ACP] + H(+) + malonyl-[ACP]
RHEA:61954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2
RHEA:11993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate + O2 => H(+) + H2O2 + L-1-piperideine-6-carboxylate
RHEA:64832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + benzoyl-CoA = 3-hydroxy-benzyl benzoate + CoA
RHEA:19734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) => bacteriochlorophyllide a + H(+) + NADH
REACT:R-HSA-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Homo sapiens)
RHEA:61838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosteryl 3-beta-D-glucoside + H(+) + UDP => ergosterol + UDP-alpha-D-glucose
RHEA:18211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4R)-bornyl diphosphate => (2E)-geranyl diphosphate
RHEA:21131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + zymosterol <=> fecosterol + H(+) + S-adenosyl-L-homocysteine
RHEA:40041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate => 2 ATP + 2 L-glutamate + N-acetyl-L-aspartate
RHEA:21251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + RNA(n) <=> diphosphate + RNA(n+1)
REACT:R-BTA-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Bos taurus)
REACT:R-BTA-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Bos taurus)
REACT:R-DME-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Drosophila melanogaster)
REACT:R-GGA-193682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves the p75NTR transmembrane domain (Gallus gallus)
RHEA:57987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP
RHEA:61678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP
RHEA:69252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate = 2-(thiiran-2-yl)acetonitrile + sulfate
REACT:R-RNO-163825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)
RHEA:24589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-arabinose => ADP + D-arabinose 5-phosphate + H(+)
REACT:R-XTR-1855202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Xenopus tropicalis)
REACT:R-MMU-9632868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1B is phosphorylated in response to estrogen (Mus musculus)
RHEA:40795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
RHEA:44802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-6 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+)
GO:0004454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-fructose 1-phosphotransferase activity
GO:0004454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketohexokinase (phosphorylating)
GO:0004454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ketohexokinase activity
GO:0004454	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hepatic fructokinase activity
RHEA:30518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + thermospermine
REACT:R-HSA-2197564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 stimulates transcription of HES5 (Homo sapiens)
REACT:R-HSA-9664346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 gene produces IL10 protein (Homo sapiens)
REACT:R-MMU-8850961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREX2 binds PTEN and inhibits it (Mus musculus)
REACT:R-SSC-378975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follitropin is a heterodimer (Sus scrofa)
REACT:R-MMU-9032751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Mus musculus)
REACT:R-XTR-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Xenopus tropicalis)
REACT:R-BTA-209921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoiodinated tyrosine can be deiodinated (Bos taurus)
REACT:R-HSA-982810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation (Homo sapiens)
REACT:R-SSC-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Sus scrofa)
RHEA:69620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
REACT:R-DME-538835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PER binds to DCO (Drosophila melanogaster)
RHEA:56963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + pyruvate <=> a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate
RHEA:58854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-oxogeraniol + NAD(+)
REACT:R-DME-6814549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA transcript initiation, Integrator binding, LEC binding (Drosophila melanogaster)
RHEA:42613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + (n+1) H(+)(in) + NADPH => a plastoquinol + n H(+)(out) + NADP(+)
RHEA:57583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thiol-D-ribulose 5-phosphate
REACT:R-DRE-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Danio rerio)
RHEA:62522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine
REACT:R-CEL-170026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protons are translocated from the intermembrane space to the matrix (Caenorhabditis elegans)
RHEA:48853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 => 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
REACT:R-MMU-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Mus musculus)
RHEA:61687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycero-2-phosphocholine + H2O <=> glycerol + H(+) + phosphocholine
REACT:R-SSC-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Sus scrofa)
REACT:R-CFA-109813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1 binds SOS1 (Canis familiaris)
REACT:R-DRE-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Danio rerio)
REACT:R-HSA-8983309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)
REACT:R-CFA-936564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 inhibits MAVS-DDX58 interaction. (Canis familiaris)
RHEA:42016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH
RHEA:47830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b + N-acetylneuraminate => ganglioside GT1b + H2O
REACT:R-GGA-9708466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y486 BACH1 translocates from the nucleoplasm to the cytosol (Gallus gallus)
REACT:R-MMU-2029476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Role of myosins in phagosome formation (Mus musculus)
RHEA:72397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(in) + K(+)(in) + Na(+)(in) => 2 chloride(out) + K(+)(out) + Na(+)(out)
GO:0035496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS-1,5-galactosyltransferase activity
GO:0035496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide-1,5-galactosyltransferase activity
GO:0035496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase
REACT:R-MMU-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Mus musculus)
REACT:R-CEL-1234173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
REACT:R-GGA-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Gallus gallus)
REACT:R-MMU-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Mus musculus)
RHEA:39238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytriacontanoyl-CoA <=> (2E)-triacontenoyl-CoA + H2O
REACT:R-HSA-1888198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 (Homo sapiens)
REACT:R-SSC-2584246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT1-GTP hydrolyses its bound GTP to GDP (Sus scrofa)
REACT:R-CEL-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Caenorhabditis elegans)
REACT:R-RNO-391913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR2 binds FPR2 ligands (Rattus norvegicus)
REACT:R-XTR-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Xenopus tropicalis)
REACT:R-SCE-71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Saccharomyces cerevisiae)
GO:0102493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	wogonin 7-O-glucosyltransferase activity
REACT:R-SPO-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Schizosaccharomyces pombe)
REACT:R-DRE-9641111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin transfers Ub to misfolded proteins (Danio rerio)
GO:0004726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-membrane spanning protein tyrosine phosphatase activity
RHEA:55636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate
RHEA:23576	skos:prefLabel	"berbamunine synthase"
RHEA:23576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"berbamunine synthase"
RHEA:23576	skos:altLabel	"(S)-N-methylcoclaurine oxidase (C-O phenol-coupling)"
RHEA:23576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + staphylopine
REACT:R-HSA-199203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK1/3/4 phosphorylate PanK (Homo sapiens)
REACT:R-PFA-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Plasmodium falciparum)
REACT:R-SSC-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Sus scrofa)
REACT:R-HSA-1467269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins bind microbial membranes causing disruption (Homo sapiens)
RHEA:22964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ornithine decarboxylase"
RHEA:22964	skos:prefLabel	"ornithine decarboxylase"
RHEA:22964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-ornithine = CO2 + putrescine
RHEA:22964	skos:altLabel	"L-ornithine carboxy-lyase"
RHEA:66499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
REACT:R-DRE-9705584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer binds statins (Danio rerio)
REACT:R-XTR-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Xenopus tropicalis)
REACT:R-RNO-2396002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Rattus norvegicus)
REACT:R-XTR-8875558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 binds CRK,CRKL (Xenopus tropicalis)
RHEA:18606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-amino-1-deoxy-scyllo-inositol + ATP => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)
RHEA:57969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:37194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-AMP + H2O <=> adenosine 2'-phosphate + H(+)
RHEA:62204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal
RHEA:70932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + dopamine(out) + 2 Na(+)(out) => chloride(in) + dopamine(in) + 2 Na(+)(in)
REACT:R-HSA-9716160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 M protein binds MAVS (Homo sapiens)
REACT:R-SSC-5357776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)
REACT:R-XTR-159868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor VII to factor VII (Xenopus tropicalis)
REACT:R-GGA-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Gallus gallus)
REACT:R-XTR-5687675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates remaining SSBs in MMEJ (Xenopus tropicalis)
RHEA:56281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] => AMP + L-prolyl-[peptidyl-carrier protein]
RHEA:47624	skos:prefLabel	"cis-L-3-hydroxyproline dehydratase"
RHEA:47624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O
RHEA:47624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-L-3-hydroxyproline dehydratase"
RHEA:47624	skos:altLabel	"cis-L-3-hydroxyproline hydro-lyase"
REACT:R-DDI-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Dictyostelium discoideum)
REACT:R-DDI-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-DME-425822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Drosophila melanogaster)
GO:0048306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent protein binding
RHEA:41148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:17330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S,4R)-borneol + NAD(+) => (1R,4R)-camphor + H(+) + NADH
RHEA:20157	skos:altLabel	"PVA dehydrogenase"
RHEA:20157	skos:prefLabel	"polyvinyl alcohol dehydrogenase (cytochrome)"
RHEA:20157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polyvinyl alcohol dehydrogenase (cytochrome)"
RHEA:20157	skos:altLabel	"PVADH"
RHEA:20157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] = an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)
RHEA:14634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate
REACT:R-RNO-3858495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits GTP-bound RHOA (Rattus norvegicus)
RHEA:52185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Saccharomyces cerevisiae)
REACT:R-GGA-114671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vWF binds to collagen (Gallus gallus)
REACT:R-XTR-8848864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARAP1 (Xenopus tropicalis)
RHEA:17953	skos:altLabel	"3-hydroxyanthranilic acid oxidase"
RHEA:17953	skos:prefLabel	"3-hydroxyanthranilate 3,4-dioxygenase"
RHEA:17953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxyanthranilate 3,4-dioxygenase"
RHEA:17953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde
RHEA:17953	skos:altLabel	"3-hydroxyanthranilic acid dioxygenase"
RHEA:17953	skos:altLabel	"3-hydroxyanthranilate oxygenase"
REACT:R-HSA-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Homo sapiens)
REACT:R-XTR-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Xenopus tropicalis)
RHEA:72236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) => 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)
RHEA:33753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O
RHEA:48915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1a <=> CMP + ganglioside GT1a + H(+)
RHEA:31197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanoyl-CoA + H(+) + NADH => (3S)-hydroxyoctanoyl-CoA + NAD(+)
REACT:R-BTA-426489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC binds inexactly matching target RNAs (Bos taurus)
REACT:R-RNO-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Rattus norvegicus)
RHEA:24146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA
REACT:R-HSA-9712087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK fusions phosphorylate FRS (Homo sapiens)
REACT:R-SPO-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Schizosaccharomyces pombe)
REACT:R-DME-6810392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMEM55B translocates to the nucleus (Drosophila melanogaster)
GO:0043997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H4-K12 specific)
GO:0043997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4-K12 acetyltransferase activity
GO:0043997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H4-K12 specific)
GO:0043997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K12 acetyltransferase activity
GO:0043997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H4-K12 specific)
RHEA:27544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde => methanol + N,N-dimethyl-4-nitrosoaniline
REACT:R-HSA-1475017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Homo sapiens)
REACT:R-GGA-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Gallus gallus)
RHEA:44159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 5-phosphate + H2O <=> myo-inositol + phosphate
REACT:R-RNO-211247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DNA by DFF40 (Rattus norvegicus)
GO:0002060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine base binding
GO:0002060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine binding
GO:0002060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine nucleobase binding
GO:0102900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroabietadienal hydroxylase activity
RHEA:40851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + FADH2
REACT:R-XTR-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)
REACT:R-RNO-981814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC2 transfers sialic acid to Core 1 mucins (Rattus norvegicus)
RHEA:36987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine
REACT:R-CFA-70679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 oxidises L-GluSS to Glu (Canis familiaris)
REACT:R-XTR-5696968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP20, USP33 deubiquitinate ADRB2 (Xenopus tropicalis)
RHEA:39964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate
GO:2001070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amidon binding
GO:2001070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	starch binding
GO:2001070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amylum binding
RHEA:15895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(2+) + sirohydrochlorin => Co-sirohydrochlorin + 2 H(+)
REACT:R-SPO-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)
REACT:R-MMU-416559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Rho-GTP by p190RhoGAP (Mus musculus)
REACT:R-SSC-174706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Sus scrofa)
REACT:R-MMU-4332359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active calmodulin binds CAMK2 (Mus musculus)
REACT:R-CFA-77319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Canis familiaris)
RHEA:65087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:25830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O => AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2
REACT:R-XTR-1474266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibrils (Xenopus tropicalis)
RHEA:48320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 + GDP-beta-L-fucose = ganglioside Fuc-GA1 + GDP + H(+)
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(5),N(10)-methylenetetrahydromethanopterin reductase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydromethanopterin cyclohydrolase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5,N10-methylenetetrahydromethanopterin reductase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylenetetrahydromethanopterin reductase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylene-H4MPT reductase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydromethanopterin reductase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylene-H(4)MPT reductase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity
GO:0018537	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity
RHEA:14600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:29606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] <=> 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:51727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-tetraphosphate + ADP + 2 H(+)
REACT:R-DRE-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Danio rerio)
REACT:R-HSA-8950183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B binds IL23A (Homo sapiens)
REACT:R-SSC-8948775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKRN1 polyubiquitinates PTEN (Sus scrofa)
REACT:R-CFA-8851954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)
REACT:R-XTR-5229111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 transports APP from trans-Golgi network to endosome lumen (Xenopus tropicalis)
RHEA:67267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine <=> (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine
REACT:R-MMU-176604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Mus musculus)
REACT:R-HSA-4551555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RYK binds WNT5A and VANGL2 (Homo sapiens)
REACT:R-SCE-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Saccharomyces cerevisiae)
REACT:R-RNO-9654533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B recycles to the plasma membrane (Rattus norvegicus)
REACT:R-DDI-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Dictyostelium discoideum)
REACT:R-GGA-6782004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the pre-incision complex in TC-NER (Gallus gallus)
RHEA:70964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-phenylalanine + H2O + O2 => 3-phenylpyruvate + H2O2 + NH4(+)
RHEA:32617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-oxogeraniol + NADP(+)
RHEA:15837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + methylamine = N-methyl-L-glutamate + NH4(+)
RHEA:15837	skos:prefLabel	"methylamine--glutamate N-methyltransferase"
RHEA:15837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylamine--glutamate N-methyltransferase"
RHEA:15837	skos:altLabel	"N-methylglutamate synthase"
REACT:R-MMU-2395324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysyl-pyrrole cross-links (Mus musculus)
REACT:R-BTA-392053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS binds Grb2 bound to pFAK:NCAM1 (Bos taurus)
REACT:R-HSA-3229181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALM1:Ca2+ binds CNG channel (Homo sapiens)
REACT:R-GGA-444171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR2 binds carboxylates (Gallus gallus)
REACT:R-SSC-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Sus scrofa)
REACT:R-RNO-163670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear transport of pChREBP (Thr 666) protein (Rattus norvegicus)
EC:3.1.3.108	skos:prefLabel	"nocturnin"
EC:3.1.3.108	skos:altLabel	"nocturnin (curled)"
EC:3.1.3.108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nocturnin"
GO:0042071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucokinin receptor activity
RHEA:72044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + orotate(out) => L-glutamate(out) + orotate(in)
REACT:R-DRE-3777129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC3 containing complexes deacetylate histone (Danio rerio)
REACT:R-SPO-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Schizosaccharomyces pombe)
GO:0019205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleobase, nucleoside, nucleotide kinase activity
GO:0019205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleobase-containing compound kinase activity
REACT:R-SSC-5218643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90AA1 binds p-6Y-VEGFR2 (Sus scrofa)
GO:0043728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-keto-4-methylthiobutyrate aminotransferase activity
REACT:R-MMU-8863471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR is bound by DAB2 and ARH (Mus musculus)
RHEA:42678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide => L-cysteine + L-histidine + O2
REACT:R-HSA-5655295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)
REACT:R-HSA-74743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-Y427-SHC1 from insulin receptor (Homo sapiens)
REACT:R-CFA-428918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:G13 complex (Canis familiaris)
RHEA:39046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5654631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PPTN11 (Homo sapiens)
REACT:R-CFA-6807578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface in the phagosome (Canis familiaris)
REACT:R-HSA-9017398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 coactivator complex binds HEYL gene promoter (Homo sapiens)
RHEA:12686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 mycothiol + NADP(+) => H(+) + mycothione + NADPH
RHEA:39234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-triacontanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytriacontanoyl-CoA + NADP(+)
REACT:R-CEL-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Caenorhabditis elegans)
REACT:R-DRE-9009371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of AP1 transcriptional activator complexes to CCND1 promoter (Danio rerio)
RHEA:65238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutyl acetate + CoA => 3-methylbutanol + acetyl-CoA
REACT:R-SSC-2168046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XII degradation by MMP12 (Sus scrofa)
RHEA:27465	skos:prefLabel	"D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase"
RHEA:27465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate
RHEA:27465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase"
RHEA:27465	skos:altLabel	"D-glycero-D-manno-heptose-1beta-phosphate adenylyltransferase"
REACT:R-DME-8950181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y693-STAT4 dimer translocates to the nucleus (Drosophila melanogaster)
REACT:R-BTA-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
RHEA:69971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Bos taurus)
RHEA:29042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-aspartate(out) <=> ADP + H(+) + L-aspartate(in) + phosphate
REACT:R-RNO-6799246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates TP53 (Rattus norvegicus)
REACT:R-DDI-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Dictyostelium discoideum)
RHEA:40382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
REACT:R-HSA-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Homo sapiens)
GO:0047197	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacylglycerol:3beta-hydroxysterol O-acyltransferase activity
GO:0047197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triacylglycerol-sterol O-acyltransferase activity
GO:0047197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"triacylglycerol--sterol O-acyltransferase"
GO:0047197	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triacylglycerol:sterol acyltransferase activity
GO:0047197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid + a triacylglycerol = a 3beta-hydroxysteroid ester + a diacylglycerol
GO:0047197	skos:prefLabel	"triacylglycerol--sterol O-acyltransferase"
GO:0047197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triglyceride-sterol O-acyltransferase activity
REACT:R-SSC-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Sus scrofa)
RHEA:54182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-[ACP] + H(+) + NADH => a long-chain fatty aldehyde + holo-[ACP] + NAD(+)
REACT:R-CEL-5263614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)
REACT:R-DRE-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Danio rerio)
RHEA:65494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine
REACT:R-MMU-8985900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Mus musculus)
RHEA:25792	skos:altLabel	"Cu(+)-exporting ATPase"
RHEA:25792	skos:prefLabel	"P-type Cu(+) transporter"
RHEA:25792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type Cu(+) transporter"
RHEA:25792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate
RHEA:43542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase] => ATP + L-seryl-[isocitrate dehydrogenase]
RHEA:58457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + D-mannose
REACT:R-BTA-5682893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12:ATG7:CysO572-ATG7 binds ATG10 (Bos taurus)
REACT:R-CFA-8851679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR183 binds 7alpha,25-dihydroxycholesterol (Canis familiaris)
REACT:R-MMU-389532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A binds CTLA4 dimer (Mus musculus)
RHEA:21310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloartenol => (S)-2,3-epoxysqualene
REACT:R-RNO-400682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Rac1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)
RHEA:14007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-cysteine + NH4(+) => H2O + L,L-cystathionine
RHEA:13802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + hydrogen sulfide + 3 NADP(+) => 4 H(+) + 3 NADPH + sulfite
RHEA:54531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate <=> D-ribose 5-phosphate
REACT:R-SSC-173626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1r (Sus scrofa)
RHEA:38635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA
REACT:R-DRE-9026777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Danio rerio)
REACT:R-GGA-1236964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of peptide bound MHC class I complex to cell surface (Gallus gallus)
REACT:R-RNO-5682629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Rattus norvegicus)
REACT:R-GGA-8855825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTRA1 hydrolyzes ACAN (Aggrecan) (Gallus gallus)
RHEA:69060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 = H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)
GO:0005130	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	granulocyte colony-stimulating factor receptor ligand
GO:0005130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-CSF receptor ligand
GO:0005130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GC-SF receptor ligand
GO:0005130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte colony-stimulating factor receptor binding
GO:0005130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte colony stimulating factor receptor binding
GO:0005130	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	granulocyte colony-stimulating factor
RHEA:35818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate
RHEA:34686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O <=> alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)
RHEA:63194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + 2 H(+) + phosphate => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2
REACT:R-RNO-3000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BORA binds SCF-beta-TrCp1/2 (Rattus norvegicus)
REACT:R-DME-432533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP1 binds to phosphorylated TIM (Drosophila melanogaster)
REACT:R-SSC-8879117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT2 transfers GlcNAc to Man-DAG1 (Sus scrofa)
RHEA:39838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + phosphate
REACT:R-RNO-70679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 oxidises L-GluSS to Glu (Rattus norvegicus)
RHEA:65758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]
RHEA:64614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Gln)
RHEA:41062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA
REACT:R-CEL-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)
RHEA:28300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-RNO-3249371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylates STAT6 at Ser407 (Rattus norvegicus)
REACT:R-HSA-5654608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS bind to PPTN11 (Homo sapiens)
REACT:R-CFA-74742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 (Canis familiaris)
RHEA:57293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O => a guanosine in RNA + glycolate + H(+)
REACT:R-DME-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Drosophila melanogaster)
REACT:R-SPO-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Schizosaccharomyces pombe)
REACT:R-SCE-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Saccharomyces cerevisiae)
REACT:R-DRE-2404134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4:atROL binds TTR (Danio rerio)
RHEA:15242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9022764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK1 gene expression is inhibited by MECP2 (Homo sapiens)
REACT:R-XTR-1678650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses Heparan sulfate chain(5) (Xenopus tropicalis)
REACT:R-HSA-2507854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Homo sapiens)
RHEA:17291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O
RHEA:39143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH
GO:0102729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocampestanol hydroxylase activity
REACT:R-BTA-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Bos taurus)
GO:0097472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin-dependent protein kinase activity
RHEA:22378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(38/39/40) in tRNA => uridine(38/39/40) in tRNA
RHEA:57472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + UDP-alpha-D-glucose = 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP
RHEA:27737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O <=> 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate
REACT:R-CEL-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Caenorhabditis elegans)
REACT:R-GGA-179467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Gallus gallus)
RHEA:20953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:30608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-phytofluene => AH2 + all-trans-zeta-carotene
RHEA:10803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + XMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
RHEA:12864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + H(+) + H2O <=> NH4(+) + xanthosine
RHEA:66180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + bilirubin-glucuronoside(in) + H2O = ADP + bilirubin-glucuronoside(out) + H(+) + phosphate
RHEA:59693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotriono-1,5-lactone + H2O => D-cellotrionate + H(+)
GO:0015577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol transmembrane transporter activity
GO:0015577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol(in) = galactitol(out)
GO:0015577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol permease activity
REACT:R-CFA-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Canis familiaris)
REACT:R-CFA-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Canis familiaris)
RHEA:68113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propanamide => NH4(+) + propanoate
REACT:R-MMU-74059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Mus musculus)
REACT:R-SCE-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Saccharomyces cerevisiae)
REACT:R-SCE-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Saccharomyces cerevisiae)
RHEA:26543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-piperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + NH4(+)
REACT:R-SSC-975097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)
REACT:R-XTR-2404135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4 binds atROL (Xenopus tropicalis)
RHEA:32095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)
RHEA:32095	skos:prefLabel	"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase"
RHEA:32095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase"
RHEA:32095	skos:altLabel	"dTDP-D-Fucp3N acetylase"
RHEA:70553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose
RHEA:20219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + formaldehyde => H(+) + trimethylamine N-oxide
REACT:R-CFA-193780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Canis familiaris)
RHEA:25638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + sulfoacetaldehyde => 2 H(+) + NADH + sulfoacetate
RHEA:38221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol
REACT:R-MMU-1614336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Mus musculus)
REACT:R-CFA-140806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINC1 binds SERPINC1 activators (Canis familiaris)
REACT:R-HSA-1445144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) (Homo sapiens)
REACT:R-MMU-9627104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP3 (Mus musculus)
RHEA:19339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hyponitrous acid + 2 NADH => 2 hydroxylamine + 2 NAD(+)
RHEA:16003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + methylamine => H(+) + H2O + N(6)-methyl-AMP
REACT:R-DDI-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Dictyostelium discoideum)
RHEA:30278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H2O2 <=> A + 2 H2O
REACT:R-DME-214405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)
RHEA:57680	skos:altLabel	"CYP93B16"
RHEA:57680	skos:altLabel	"CYP93G1"
RHEA:57680	skos:prefLabel	"flavone synthase II"
RHEA:57680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavone synthase II"
RHEA:57680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:64849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hex-3-en-1-ol + benzoyl-CoA => (3Z)-hex-3-en-1-yl benzoate + CoA
GO:0019148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cysteine desulfhydrase activity
GO:0019148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-cysteine sulfide-lyase (deaminating)
GO:0019148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-cysteine sulfide-lyase (deaminating; pyruvate-forming)
GO:0019148	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-cysteine lyase activity
RHEA:29976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine(in) + H(+)(in) => 2'-deoxycytidine(out) + H(+)(out)
REACT:R-DRE-209087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBA is phosphorylated by Phospho IKKB kinase (Danio rerio)
RHEA:45924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:32515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)
REACT:R-RNO-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Rattus norvegicus)
RHEA:59838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]
REACT:R-SSC-211968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2W1 oxidises INDOL (Sus scrofa)
RHEA:16928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + S-adenosyl-L-methionine <=> (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-8850997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 binds PTEN (Rattus norvegicus)
REACT:R-BTA-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Bos taurus)
GO:0050041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-lactate acetaldehyde-lyase (formate-forming)
GO:0050041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate aldolase activity
GO:0050041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-lactate acetaldehyde-lyase activity
GO:0050041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactate synthase activity
REACT:R-DRE-9710263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GZMB cleaves GSDME (Danio rerio)
GO:0008308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	voltage-dependent ion-selective channel activity
GO:0008308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Homo sapiens)
GO:0008308	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	voltage-gated ion-selective channel activity
GO:0008308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated anion channel activity
REACT:R-GGA-1433501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other adapter proteins with p-KIT (Gallus gallus)
GO:0052884	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinoid isomerohydrolase activity
GO:0052884	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinol isomerase activity
GO:0052884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Homo sapiens)
GO:0052884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
GO:0052884	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	all-trans-retinol isomerase:hydrolase activity
GO:0052884	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	all-trans-retinyl-palmitate hydrolase activity
GO:0102219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglucan, water dikinase"
GO:0102219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate
GO:0102219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphogluco-amylopectin water dikinase activity
GO:0102219	skos:prefLabel	"phosphoglucan, water dikinase"
RHEA:17640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene <=> hop-22(29)-ene
RHEA:34482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate <=> 15-cis-phytoene + diphosphate
REACT:R-DDI-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Dictyostelium discoideum)
REACT:R-HSA-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Homo sapiens)
RHEA:46573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CEL-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
REACT:R-CEL-1602417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Caenorhabditis elegans)
REACT:R-DME-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Drosophila melanogaster)
RHEA:28888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-serine(in) => H(+)(out) + L-serine(out)
GO:0070026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide binding
GO:0070026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrosyl binding
GO:0070026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NO binding
GO:0070026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrogen monoxide binding
REACT:R-PFA-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)
RHEA:30454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> isomultiflorenol
GO:0017147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wnt-protein binding
GO:0050483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP = inosine + phosphate
GO:0050483	skos:prefLabel	"IMP-specific 5'-nucleotidase"
GO:0050483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP 5' nucleotidase activity
GO:0050483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"IMP-specific 5'-nucleotidase"
GO:0050483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP-GMP specific 5'-nucleotidase activity
GO:0050483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP 5'-nucleotidase activity
RHEA:15099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate => 5-formimidoyltetrahydrofolate + L-glutamate
REACT:R-MMU-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Mus musculus)
REACT:R-MMU-8956140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 and UBD bind NUB1 and the 26S proteasome (Mus musculus)
RHEA:59279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine <=> D-glutamine
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plasma alpha-3-fucosyltransferase activity
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase"
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Lewis-negative alpha-3-fucosyltransferase activity
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity
GO:0017083	skos:altLabel	"Lewis-negative alpha-3-fucosyltransferase"
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity
GO:0017083	skos:prefLabel	"4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase"
GO:0017083	skos:altLabel	"plasma alpha-3-fucosyltransferase"
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactoside 3-L-fucosyltransferase activity
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)
GO:0017083	skos:altLabel	"guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase"
GO:0017083	skos:altLabel	"GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase"
GO:0017083	skos:altLabel	"galactoside 3-fucosyltransferase"
GO:0017083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactoside 3-fucosyltransferase activity
RHEA:49542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate
REACT:R-BTA-442291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV2 is a GEF for Rho/Rac family kinases (Bos taurus)
REACT:R-BTA-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Bos taurus)
RHEA:33357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA
REACT:R-GGA-202706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha4beta1 binds JAM2:JAM3 (Gallus gallus)
REACT:R-DDI-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Dictyostelium discoideum)
REACT:R-SSC-8983300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Sus scrofa)
RHEA:71638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) + 2 thiosulfate(out) <=> phosphate(out) + 2 thiosulfate(in)
RHEA:36326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z)-octadecen-1-ol + CoA + 2 NADP(+)
REACT:R-RNO-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Rattus norvegicus)
REACT:R-CFA-77586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Canis familiaris)
RHEA:52025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => 18S-resolvin E2 + A + H2O
REACT:R-DRE-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Danio rerio)
REACT:R-SSC-6788912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHPP:Mg2+ dimer hydrolyses PPi (Sus scrofa)
REACT:R-HSA-1655844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Squalene Monooxygenase (SQLE) (Homo sapiens)
GO:0033328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisome membrane targeting sequence binding
GO:0033328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisomal membrane protein (PMP) targeting signal (mPTS) binding
GO:0033328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mPTS binding
GO:0033328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP targeting signal binding
GO:0033328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP targeting signal (mPTS) binding
RHEA:51709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-altritol + NAD(+) => H(+) + keto-D-tagatose + NADH
REACT:R-DME-9661408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Drosophila melanogaster)
RHEA:21356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arabinitol 2-dehydrogenase"
RHEA:21356	skos:prefLabel	"L-arabinitol 2-dehydrogenase"
RHEA:21356	skos:altLabel	"L-arabinitol 2-dehydrogenase (ribulose forming)"
RHEA:21356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NAD(+) = H(+) + L-ribulose + NADH
RHEA:48839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
REACT:R-SSC-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Sus scrofa)
RHEA:41569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin T + dTDP-2-deoxy-beta-L-fucose => aclacinomycin S + dTDP + H(+)
RHEA:65507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O <=> 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine
RHEA:42581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine + tRNA(Sec) => AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)
REACT:R-SSC-375339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Sus scrofa)
REACT:R-MMU-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Mus musculus)
RHEA:20183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP => alpha-D-mannose derivative + UDP-alpha-D-glucose
REACT:R-MMU-68960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase epsilon binds at the origin (Mus musculus)
REACT:R-GGA-165758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and inactivation of eEF2K by activated S6K1 (Gallus gallus)
REACT:R-BTA-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Bos taurus)
REACT:R-HSA-508163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Homo sapiens)
REACT:R-HSA-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
REACT:R-CEL-8875523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS3 (Caenorhabditis elegans)
RHEA:17095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)
RHEA:42282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
GO:0098809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite reductase activity
REACT:R-RNO-8851538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
RHEA:13619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(methylsulfanyl)-D-ribose + adenine => H2O + S-methyl-5'-thioadenosine
REACT:R-DRE-9632034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GlcA to chondroitin (Danio rerio)
REACT:R-DRE-373732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin trans-homophilic interaction (Danio rerio)
REACT:R-BTA-9796691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPATA2 links CYLD to LUBAC (Bos taurus)
GO:0045437	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine ribohydrolase activity
GO:0045437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine nucleosidase activity
GO:0045437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine hydrolase activity
REACT:R-HSA-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Homo sapiens)
REACT:R-GGA-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Gallus gallus)
REACT:R-HSA-8944397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T69,T71-ATF2 binds PTEN gene promoter (Homo sapiens)
REACT:R-BTA-372529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of acetylcholine at the synapse (Bos taurus)
REACT:R-SCE-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Saccharomyces cerevisiae)
REACT:R-HSA-9661425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB dissociates (Homo sapiens)
RHEA:35947	skos:prefLabel	"chanoclavine-I aldehyde reductase"
RHEA:35947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + H(+) + NADPH
RHEA:35947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chanoclavine-I aldehyde reductase"
REACT:R-BTA-174374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
REACT:R-HSA-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
REACT:R-XTR-8982641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Xenopus tropicalis)
REACT:R-BTA-4570493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Bos taurus)
REACT:R-CFA-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Canis familiaris)
REACT:R-DRE-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Danio rerio)
GO:0102247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-malonyl acyl carrier protein-condensing enzyme activity
GO:0140355	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cargo
GO:0140355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cargo receptor ligand activity
REACT:R-DRE-5624129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LZTFL1 binds the BBSome and prevents its traffic to the cilium (Danio rerio)
REACT:R-RNO-9690439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds LTC4,LTD4,LTE4 (Rattus norvegicus)
RHEA:41245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine
REACT:R-SSC-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Sus scrofa)
REACT:R-RNO-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Rattus norvegicus)
RHEA:56683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:58217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydroserpentine => AH2 + serpentine
GO:0001406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophosphodiester transmembrane transporter activity
RHEA:69642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phlorizin <=> beta-D-glucose + phloretin
REACT:R-GGA-9609310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β-blockers bind ADRB1,2,3 (Gallus gallus)
EC:3.4.22.56	skos:prefLabel	"caspase-3"
EC:3.4.22.56	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-3"
EC:3.4.22.56	skos:altLabel	"CPP32"
EC:3.4.22.56	skos:altLabel	"yama protein"
EC:3.4.22.56	skos:altLabel	"CASP-3"
EC:3.4.22.56	skos:altLabel	"apopain"
GO:0102877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-copaene synthase activity
REACT:R-HSA-5682012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG5:ATG12 binds ATG16L1 (Homo sapiens)
RHEA:54282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2
REACT:R-HSA-180047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates DARPP-32 on Thr75 (Homo sapiens)
RHEA:66203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + H2O2
RHEA:43427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:70439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate
REACT:R-BTA-209760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Bos taurus)
RHEA:38842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:54522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloaraneosene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
RHEA:47348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)
REACT:R-BTA-1067667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R (Bos taurus)
RHEA:48248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)
REACT:R-HSA-983145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Homo sapiens)
RHEA:41963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GA1 (d18:1(4E)) + H(+) + UDP
REACT:R-DRE-5604929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C binds Protein S (Danio rerio)
RHEA:59657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotriose + O2 => D-cellotriono-1,5-lactone + H2O2
RHEA:21920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP
REACT:R-XTR-9627106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) forms dimer (Xenopus tropicalis)
REACT:R-HSA-2220964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)
REACT:R-CFA-8936214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCY2C trimer binds GUCA2A,B (Canis familiaris)
REACT:R-MMU-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Mus musculus)
RHEA:59155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + pseudomonate C <=> AMP + diphosphate + pseudomonoyl-CoA C
GO:0047536	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-aminoadipate aminotransferase activity
GO:0047536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoadipate transaminase activity
GO:0047536	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate-alpha-ketoadipate transaminase activity
GO:0047536	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-aminoadipate:2-oxoglutarate aminotransferase activity
GO:0047536	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminoadipic aminotransferase activity
GO:0047536	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic-ketoadipic transaminase activity
GO:0047536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoadipate aminotransferase activity
RHEA:10541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
REACT:R-BTA-1605724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Bos taurus)
REACT:R-SCE-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Saccharomyces cerevisiae)
REACT:R-DRE-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Danio rerio)
RHEA:18071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arginine => L-arginine
REACT:R-SPO-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Schizosaccharomyces pombe)
REACT:R-MMU-428918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:G13 complex (Mus musculus)
RHEA:66915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenanthramide C + S-adenosyl-L-methionine <=> avenanthramide B + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Xenopus tropicalis)
REACT:R-SSC-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Sus scrofa)
RHEA:15200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine
RHEA:72422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + ATP + H(+) <=> (E)-4-coumaroyl-AMP + diphosphate
GO:0102009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline dipeptidase activity
EC:2.6.1.96	skos:altLabel	"gamma-aminobutyrate aminotransaminase"
EC:2.6.1.96	skos:altLabel	"gamma-aminobutyric acid pyruvate transaminase"
EC:2.6.1.96	skos:altLabel	"GABA transaminase"
EC:2.6.1.96	skos:prefLabel	"4-aminobutyrate--pyruvate transaminase"
EC:2.6.1.96	skos:altLabel	"4-aminobutyrate aminotransferase"
EC:2.6.1.96	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-aminobutyrate--pyruvate transaminase"
RHEA:37645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
RHEA:67919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphoramidate + H2O <=> AMP + NH4(+)
RHEA:55307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
REACT:R-CFA-374787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR neuropeptide receptor binds neuropeptides B and W (Canis familiaris)
REACT:R-XTR-9762345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDN:ALB dissociates (Xenopus tropicalis)
REACT:R-SSC-416639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Sus scrofa)
RHEA:63570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-casomorphin-6 + L-isoleucine => beta-casomorphin-7 + H2O
REACT:R-HSA-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Homo sapiens)
GO:0047796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexane-1,3-dione acylhydrolase (decyclizing)
GO:0047796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-cyclohexanedione hydrolase activity
GO:0047796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1,3-dione hydrolase activity
RHEA:33968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O => 3-maleylpyruvate + H(+)
REACT:R-BTA-2065539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:Importin beta-1 dissociates (Bos taurus)
RHEA:15189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c553] + formate = CO2 + 2 Fe(II)-[cytochrome c553] + H(+)
RHEA:15189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate dehydrogenase (cytochrome c-553)"
RHEA:15189	skos:prefLabel	"formate dehydrogenase (cytochrome c-553)"
RHEA:28547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose => alpha-D-fructose
RHEA:53998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O
RHEA:64439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycylglycyl-L-isoleucine(out) + H(+)(out) <=> glycylglycyl-L-isoleucine(in) + H(+)(in)
RHEA:64294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+) => 3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH
REACT:R-XTR-5244669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Xenopus tropicalis)
RHEA:16037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine
REACT:R-GGA-168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNKs phosphorylate c-JUN (Gallus gallus)
REACT:R-BTA-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Bos taurus)
RHEA:13519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dTDP => ATP + dTMP
REACT:R-HSA-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Homo sapiens)
GO:0042328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan sulfate N-acetylglucosaminyltransferase activity
GO:0042328	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin N-acetylglucosaminyltransferase activity
GO:0042328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan sulphate N-acetylglucosaminyltransferase activity
REACT:R-CEL-170847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Caenorhabditis elegans)
REACT:R-SSC-5368586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKK promotes clathrin-dependent internalization of LRP6 (Sus scrofa)
RHEA:68277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + L-seryl-[protein] => CoA + O-butanoyl-L-seryl-[protein]
GO:0004937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha1 adrenoceptor
GO:0004937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha1-adrenergic receptor activity
GO:0016744	skos:prefLabel	"Transketolases and transaldolases"
GO:0016744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transketolase or transaldolase activity
GO:0016744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transketolases and transaldolases"
GO:0016744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring aldehyde or ketonic groups
RHEA:43443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + sphinganine <=> H2O + N-hexadecanoylsphinganine
REACT:R-RNO-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Rattus norvegicus)
REACT:R-RNO-141351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAOX:FAD oxidises NASPN to SPM (Rattus norvegicus)
REACT:R-SSC-750993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (q) reassociates with G beta:gamma (Sus scrofa)
REACT:R-BTA-448427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 binds Interleukin-27 receptor (Bos taurus)
REACT:R-DME-9759169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Drosophila melanogaster)
REACT:R-SSC-373738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin interacts with syntenin-1 (Sus scrofa)
REACT:R-DRE-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Danio rerio)
GO:0004649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(ADP-ribose) glycohydrolase activity
GO:0080107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-methylthiopropyl glucosinolate S-oxygenase activity
REACT:R-DRE-5229283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCNs bind lipids (Danio rerio)
RHEA:63627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-AMP + holo-[ACP] <=> AMP + H(+) + hexadecanoyl-[ACP]
RHEA:29900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-xylose(out) + H2O => ADP + D-xylose(in) + H(+) + phosphate
REACT:R-RNO-2213195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of anchoring fibrils (Rattus norvegicus)
RHEA:39480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)
REACT:R-PFA-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Plasmodium falciparum)
REACT:R-RNO-9667914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand midkine (MDK) (Rattus norvegicus)
REACT:R-SSC-400071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Sus scrofa)
RHEA:35011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fucose(in) + H(+)(in) = D-fucose(out) + H(+)(out)
REACT:R-DRE-9013021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOB (Danio rerio)
RHEA:43268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 + H(+) + UDP
RHEA:44780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-9 + S-adenosyl-L-methionine = H(+) + menaquinol-9 + S-adenosyl-L-homocysteine
REACT:R-CFA-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Canis familiaris)
EC:2.7.8.20	skos:prefLabel	"phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase"
EC:2.7.8.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase"
EC:2.7.8.20	skos:altLabel	"phosphoglycerol transferase"
REACT:R-DDI-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Dictyostelium discoideum)
RHEA:13045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-73646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
RHEA:21671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sn-glycerol 3-phosphate(out) <=> ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)
GO:0047081	skos:altLabel	"3-hydroxy-2-methylpyridinecarboxylate dioxygenase"
GO:0047081	skos:altLabel	"methylhydroxypyridinecarboxylate oxidase"
GO:0047081	skos:altLabel	"MHPCO"
GO:0047081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylhydroxypyridinecarboxylate oxidase activity
GO:0047081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase"
GO:0047081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 = 2-(acetamidomethylene)succinate + NADP(+)
GO:0047081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing)
GO:0047081	skos:prefLabel	"3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase"
GO:0047081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 = 2-(acetamidomethylene)succinate + NAD(+)
GO:0047081	skos:altLabel	"methylhydroxypyridine carboxylate dioxygenase"
GO:0047081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylhydroxypyridine carboxylate dioxygenase activity
GO:0047081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity
GO:0047081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity
GO:0047081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity
REACT:R-DRE-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Danio rerio)
RHEA:24170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate
RHEA:61763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP
REACT:R-MMU-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Mus musculus)
RHEA:62991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanamide + H2O <=> dodecanoate + NH4(+)
RHEA:42248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + CoA
RHEA:58365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain primary fatty alcohol + NADP(+) => a medium-chain fatty aldehyde + H(+) + NADPH
RHEA:70282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + stachyose <=> D-galactose + raffinose
REACT:R-BTA-167408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The high affinity receptor complex binds to G-protein (Bos taurus)
RHEA:57754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH
RHEA:15249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose = 1-O-galloyl-beta-D-glucose + UDP
REACT:R-HSA-8870698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASLG (FasL) gene expression (Homo sapiens)
RHEA:40961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
REACT:R-CFA-8857662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Canis familiaris)
RHEA:27469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chitin disaccharide deacetylase"
RHEA:27469	skos:altLabel	"chitin oligosaccharide deacetylase"
RHEA:27469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiose = acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine
RHEA:27469	skos:prefLabel	"chitin disaccharide deacetylase"
RHEA:27469	skos:altLabel	"chitin oligosaccharide amidohydolase"
RHEA:27469	skos:altLabel	"chitobiose amidohydolase"
RHEA:52941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + UDP-alpha-D-glucuronate => chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP
RHEA:18710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + taurine => AH2 + NH4(+) + sulfoacetaldehyde
REACT:R-DDI-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Dictyostelium discoideum)
RHEA:66165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + serotonin => CoA + H(+) + N-butanoylserotonin
REACT:R-GGA-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Gallus gallus)
RHEA:64246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-glycine + CoA + H(+) => a fatty acyl-CoA + glycine
EC:3.1.3.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase"
EC:3.1.3.47	skos:altLabel	"reductase phosphatase"
EC:3.1.3.47	skos:prefLabel	"[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase"
REACT:R-XTR-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Xenopus tropicalis)
REACT:R-HSA-6797974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRTMs bind NRXNs (Homo sapiens)
RHEA:39227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octacosenoyl-CoA + H(+) + NADPH = NADP(+) + octacosanoyl-CoA
REACT:R-XTR-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Xenopus tropicalis)
GO:0018703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorophenoxyacetate dehalogenase activity
RHEA:12003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + NADP(+) <=> CO2 + NADPH
REACT:R-HSA-5687103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO3 regulates MIR34B,C expression (Homo sapiens)
GO:0015923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosidase activity
RHEA:60435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cannabigerolate <=> AH2 + cannabichromenate
REACT:R-DDI-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Dictyostelium discoideum)
REACT:R-HSA-1475032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Homo sapiens)
REACT:R-BTA-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Bos taurus)
RHEA:52546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-erythronate + H(+) + NADH => D-erythronate + NAD(+)
RHEA:36932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:10125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + phenylacetone => benzyl acetate + H2O + NADP(+)
REACT:R-MMU-9664855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Mus musculus)
REACT:R-HSA-9033233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L binds cargo proteins containing PTS1 (Homo sapiens)
REACT:R-MMU-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Mus musculus)
REACT:R-CFA-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Canis familiaris)
RHEA:31587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NADH + O2 + uracil = (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)
GO:0140383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxytryptamine kinase activity
REACT:R-XTR-182993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL) (Xenopus tropicalis)
REACT:R-DME-209320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 kinase is autophosphorylated (Drosophila melanogaster)
RHEA:24049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sucrose => alpha-D-glucose 1-phosphate + D-fructose
REACT:R-HSA-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Homo sapiens)
REACT:R-CEL-198870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-HSA-9610442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP (Homo sapiens)
RHEA:43746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2) => ATP + cytidine(34) in tRNA(Ile2) + L-lysine
REACT:R-SSC-419351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF receptor binds platelet activating factor (Sus scrofa)
REACT:R-CFA-5655193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIAA0101 double monoubiquitination (Canis familiaris)
GO:0033424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCG codon-amino acid adaptor activity
GO:0033424	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proline tRNA
REACT:R-CFA-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Canis familiaris)
GO:0106355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate 3-monooxygenase [NADH] activity
GO:0106355	skos:prefLabel	"4-hydroxybenzoate 3-monooxygenase [NAD(P)H]"
GO:0106355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoate 3-monooxygenase [NAD(P)H]"
GO:0106355	skos:altLabel	"4-hydroxybenzoate 3-hydroxylase"
GO:0106355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + H(+) + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD(+)
GO:0047287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity
GO:0047287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity
GO:0047287	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase
GO:0047287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactosylceramide alpha-2,6-N-sialyltransferase activity
GO:0047287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-sialic acid:lactosylceramide sialyltransferase activity
GO:0047287	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CMP-acetylneuraminate-lactosylceramide-sialyltransferase
RHEA:51462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-glutamate => H2O + N-(9Z-octadecenoyl)-L-glutamate
REACT:R-SSC-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Sus scrofa)
REACT:R-HSA-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)
REACT:R-RNO-211186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DFF45 (224) by caspase-3 (Rattus norvegicus)
REACT:R-HSA-420274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIP receptor binds gastric inhibitory peptide (Homo sapiens)
REACT:R-SSC-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
REACT:R-SSC-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Sus scrofa)
REACT:R-XTR-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Xenopus tropicalis)
RHEA:58899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate
REACT:R-CFA-5661230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds arsenic (Canis familiaris)
REACT:R-HSA-110350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)
REACT:R-MMU-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Mus musculus)
REACT:R-BTA-9634584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Bos taurus)
REACT:R-MMU-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Mus musculus)
REACT:R-RNO-6804379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds TTC5 (Rattus norvegicus)
RHEA:11348	skos:altLabel	"arsenical pump-driving ATPase"
RHEA:11348	skos:prefLabel	"arsenite-transporting ATPase"
RHEA:11348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arsenite-transporting ATPase"
RHEA:11348	skos:altLabel	"arsenite-translocating ATPase"
RHEA:11348	skos:altLabel	"arsenical resistance ATPase"
RHEA:11348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) + phosphate
REACT:R-RNO-109822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Rattus norvegicus)
RHEA:16602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate => fumarate + NH4(+)
REACT:R-HSA-351596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine translocates to a secretory vesicle (Homo sapiens)
RHEA:53348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20a) in tRNA + NAD(+) = H(+) + NADH + uridine(20a) in tRNA
REACT:R-HSA-8850356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)
REACT:R-HSA-9749494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBIP binds IKBKB and CHUK (Homo sapiens)
RHEA:21724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nitrile + 2 H2O = a carboxylate + NH4(+)
REACT:R-HSA-5663127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds F7 gene (Homo sapiens)
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogen-lyase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H2 producing hydrogenase
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ni-Fe hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferredoxin hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogenlyase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogenase I
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogenase II
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[Fe] hydrogenase gamma
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ni-Fe-Se hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	bidirectional hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	iron hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen:ferredoxin oxidoreductase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogenase (ferredoxin) activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nickel-iron-selenium hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nickel-iron hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H2 oxidizing hydrogenase
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uptake hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	iron-only hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H(2) producing hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H(2) oxidizing hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nickel hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogenase activity
GO:0008901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Fe] hydrogenase activity
RHEA:18953	skos:prefLabel	"sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)"
RHEA:18953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
RHEA:18953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin
RHEA:18953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)"
RHEA:13269	skos:altLabel	"beta-glucocerebrosidase"
RHEA:13269	skos:altLabel	"D-glucosyl-N-acylsphingosine glucohydrolase"
RHEA:13269	skos:prefLabel	"glucosylceramidase"
RHEA:13269	skos:altLabel	"acid beta-glucosidase"
RHEA:13269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
RHEA:13269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosylceramidase"
REACT:R-HSA-8865637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFSD2A transports LPC from extracellular region to plasma membrane (Homo sapiens)
RHEA:39863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-PFA-5688834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds VCP (Plasmodium falciparum)
REACT:R-DRE-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)
REACT:R-SSC-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Sus scrofa)
REACT:R-CEL-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Caenorhabditis elegans)
REACT:R-BTA-3640872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)
REACT:R-HSA-9026358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTF4 binds NTRK2 (Homo sapiens)
REACT:R-GGA-549304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal clearance of organic cations (Gallus gallus)
REACT:R-MMU-983427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of peptide bound class I MHC on cell surface (Mus musculus)
RHEA:60392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O = Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)
REACT:R-DME-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Drosophila melanogaster)
REACT:R-SCE-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Saccharomyces cerevisiae)
RHEA:22122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + phosphate + succinyl-CoA => CoA + GTP + succinate
RHEA:38596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)
RHEA:49168	skos:prefLabel	"bacteriochlorophyllide d C-12(1)-methyltransferase"
RHEA:49168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacteriochlorophyllide d C-12(1)-methyltransferase"
RHEA:49168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine
RHEA:52523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-174731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of newly synthesized ApoB-48 (Rattus norvegicus)
REACT:R-GGA-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Gallus gallus)
REACT:R-HSA-8950581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Cofilin-1 (Homo sapiens)
REACT:R-XTR-9023626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Xenopus tropicalis)
REACT:R-SCE-446214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Saccharomyces cerevisiae)
RHEA:40161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
RHEA:30851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
GO:0102278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose synthase activity
REACT:R-RNO-6811454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate PP2A (Rattus norvegicus)
REACT:R-SSC-9034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 dimers trans-autophosphorylate (Sus scrofa)
RHEA:39255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)
RHEA:59524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] = 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]
RHEA:37786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-9014074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin4 (Canis familiaris)
RHEA:52870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate
REACT:R-DRE-2022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to heparan (Danio rerio)
REACT:R-DDI-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)
REACT:R-MMU-195418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-2 associates with VEGFR1 forming complexes on  cell surface (Mus musculus)
REACT:R-SSC-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Sus scrofa)
REACT:R-HSA-9023173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin secretory granule docks at the plasma membrane (Homo sapiens)
REACT:R-CFA-6788295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDHD1:Mg2+ dephosphorylates PURIDP (Canis familiaris)
RHEA:45530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-3769393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ binds p-CBY:CTNNB1 (Canis familiaris)
GO:0050606	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity
GO:0050606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity
GO:0050606	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity
GO:0050606	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP(+) oxidoreductase activity
GO:0050606	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity
REACT:R-DRE-8866329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP lipidates APOB-100, forming a pre-VLDL (Danio rerio)
GO:0004222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metalloendopeptidase activity
GO:0004222	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoproteinase activity
GO:0004222	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metalloendoprotease activity
REACT:R-PFA-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Plasmodium falciparum)
RHEA:51768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate = 4-prenylphlormethylbutanophenone + diphosphate
REACT:R-XTR-266012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTD4 is converted to LTE4 by DPEP1/2 (Xenopus tropicalis)
REACT:R-DDI-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Dictyostelium discoideum)
RHEA:22322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + 2 phosphate => 2 alpha-D-glucose 1-phosphate + H2O
RHEA:66631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 <=> (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2
REACT:R-CFA-163217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Canis familiaris)
RHEA:50505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]
REACT:R-BTA-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Bos taurus)
REACT:R-XTR-3249370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 dimer migrates to the nucleus (Xenopus tropicalis)
RHEA:55046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-tetradecadienoate + CoA + H(+) => (3E,5Z)-tetradecadienoyl-CoA + H2O
REACT:R-MMU-5660980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S276-RELA binds RELB (Mus musculus)
RHEA:55022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-diaminouracil + D-ribose 5-phosphate => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O
RHEA:14853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + chloride + H(+)
RHEA:14853	skos:prefLabel	"4-chlorobenzoyl-CoA dehalogenase"
RHEA:14853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-chlorobenzoyl-CoA dehalogenase"
RHEA:23930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + spermidine => H2O + N(8)-acetylspermidine
REACT:R-MMU-9008052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10(?-152) binds IL1RAPL1 (Mus musculus)
REACT:R-RNO-9757139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Rattus norvegicus)
REACT:R-RNO-209532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR C-terminal fragment enters endosomes (Rattus norvegicus)
RHEA:36232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
RHEA:41232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:56563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP
RHEA:61486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine
REACT:R-DRE-977317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Danio rerio)
GO:0050125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-benzyloxycarbonylglycine = benzyl alcohol + CO2 + glycine
GO:0050125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-benzyloxycarbonylglycine urethanehydrolase activity
GO:0050125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity
GO:0050125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-benzyloxycarbonylglycine hydrolase activity
GO:0050125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-benzyloxycarbonylglycine hydrolase"
GO:0050125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nalpha-benzyloxycarbonyl amino acid urethane hydrolase I
GO:0050125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nalpha-carbobenzoxyamino acid amidohydrolase activity
GO:0050125	skos:prefLabel	"N-benzyloxycarbonylglycine hydrolase"
GO:0050125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzyloxycarbonylglycine hydrolase activity
GO:0043739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GU mismatch-specific uracil-DNA glycosylase activity
GO:0043739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G/U mismatch-specific uracil-DNA glycosylase activity
GO:0043739	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uracil mismatch repair protein
GO:0043739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUG
REACT:R-MMU-5607753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD9 oligomerizes (Mus musculus)
RHEA:13054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + pyruvate => 3-phenylpyruvate + L-alanine
EC:7.5.2.6	skos:prefLabel	"ABC-type lipid A-core oligosaccharide transporter"
EC:7.5.2.6	skos:altLabel	"lipid flippase"
EC:7.5.2.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type lipid A-core oligosaccharide transporter"
EC:7.5.2.6	skos:altLabel	"ATP-dependent lipid A-core flippase"
REACT:R-BTA-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)
GO:0043733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-3-methylbase glycosylase activity
GO:0043733	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Mag III
GO:0043733	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MagIII
GO:0043733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-3-methyladenine glycosylase III
REACT:R-DRE-187934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Danio rerio)
RHEA:58589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate + NADPH => (+)-vincadifformine + acetate + NADP(+)
REACT:R-SSC-352268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Satb1 (Sus scrofa)
RHEA:34574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + diphosphate + NADP(+) <=> H(+) + NADPH + presqualene diphosphate
REACT:R-HSA-8949668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YME1L1 proteolyzes unassembled proSMDT1 (Homo sapiens)
RHEA:39310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH <=> (11Z,14Z)-eicosadienoyl-CoA + NADP(+)
GO:0047189	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalyldiaminopropionate synthase activity
GO:0047189	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity
GO:0047189	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity
GO:0047189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-diaminopropionate N-oxalyltransferase activity
GO:0047189	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity
GO:0047189	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalyldiaminopropionic synthase activity
GO:0047189	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ODAP synthase activity
GO:0001861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C4b receptor activity
REACT:R-HSA-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)
REACT:R-GGA-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Gallus gallus)
REACT:R-HSA-1112690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds CBL (Homo sapiens)
RHEA:60782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A24 + H2O + succinate => 2-oxoglutarate + gibberellin A15 + O2
RHEA:37037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-2-aminopentanoate + NAD(+)
RHEA:54848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexan-3-one + NADPH + O2 = H2O + NADP(+) + propyl propanoate
REACT:R-SCE-109860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 phosphorylates MAPK3 (Saccharomyces cerevisiae)
RHEA:70771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
RHEA:68775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> diphosphate + germacrene C
REACT:R-CFA-193845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
REACT:R-BTA-193792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Bos taurus)
REACT:R-DRE-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Danio rerio)
RHEA:31536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginine + O2 => (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate
REACT:R-XTR-9034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 dimers trans-autophosphorylate (Xenopus tropicalis)
REACT:R-XTR-9025996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Xenopus tropicalis)
REACT:R-PFA-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)
REACT:R-SCE-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)
RHEA:60325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine
REACT:R-BTA-9667965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds PP2A (Bos taurus)
RHEA:29497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:35941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + tryprostatin B => brevianamide F + dimethylallyl diphosphate
REACT:R-XTR-8852013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL8 binds resting T cell surface (Xenopus tropicalis)
REACT:R-GGA-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Gallus gallus)
RHEA:53161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-sn-glycero-3-phosphoethanolamine => an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate
REACT:R-DME-163010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Down Regulation of Emi1 through Phosphorylation of Emi1 (Drosophila melanogaster)
REACT:R-HSA-482770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet secretory granule components (Homo sapiens)
REACT:R-CEL-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Caenorhabditis elegans)
RHEA:28887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out)
RHEA:70334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyphenylacetyl-CoA + H2O <=> 3-hydroxyphenylacetate + CoA + H(+)
RHEA:39562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O
RHEA:49830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:36123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine
REACT:R-DME-6806674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Drosophila melanogaster)
RHEA:46739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monoacyl-sn-glycero-3-phosphate <=> a monoacylglycerol + phosphate
REACT:R-DRE-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Danio rerio)
REACT:R-RNO-9029690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-6 translocates to the nucleus (Rattus norvegicus)
RHEA:40977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O
REACT:R-XTR-4724279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Xenopus tropicalis)
REACT:R-HSA-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
REACT:R-MMU-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Mus musculus)
RHEA:15176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + NADPH <=> 2 H2O + NADP(+)
RHEA:61680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-cysteine = AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]
RHEA:61680	skos:prefLabel	"L-cysteine--[L-cysteinyl-carrier protein] ligase"
RHEA:61680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-cysteine--[L-cysteinyl-carrier protein] ligase"
RHEA:40576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + H2O => CoA + glutarate + H(+)
GO:0033814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanoyl-CoA C-acyltransferase activity
GO:0033814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity
GO:0033814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol carrier protein-chi
GO:0033814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA
GO:0033814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SCPchi
GO:0033814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol carrier protein-X
GO:0033814	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peroxisomal thiolase 2 activity
GO:0033814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SCP-X
GO:0033814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTE-2
REACT:R-SPO-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Schizosaccharomyces pombe)
REACT:R-DRE-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Danio rerio)
RHEA:22162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA => 4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside
REACT:R-SSC-8848864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARAP1 (Sus scrofa)
EC:1.1.1.351	skos:prefLabel	"phosphogluconate dehydrogenase [NAD(P)(+)-dependent, decarboxylating]"
EC:1.1.1.351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphogluconate dehydrogenase [NAD(P)(+)-dependent, decarboxylating]"
GO:0003939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-sorbitol dehydrogenase
GO:0003939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sorbitol dehydrogenase activity
GO:0003939	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyol dehydrogenase activity
GO:0003939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-iditol (sorbitol) dehydrogenase activity
GO:0003939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+-dependent sorbitol dehydrogenase activity
GO:0003939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-iditol:NAD oxidoreductase activity
GO:0003939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent sorbitol dehydrogenase activity
GO:0003939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucitol dehydrogenase activity
GO:0003939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-iditol 2-dehydrogenase activity
GO:0003939	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-iditol:NAD+ 5-oxidoreductase activity
REACT:R-HSA-5579084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective AHCY does not hydrolyse AdoHcy (Homo sapiens)
REACT:R-MMU-4093329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SDCBP (Mus musculus)
REACT:R-GGA-451450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 (Gallus gallus)
REACT:R-MMU-1564164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type V degradation by MMP2,9,10 (Mus musculus)
REACT:R-SSC-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Sus scrofa)
RHEA:53412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
REACT:R-CEL-9632412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 is recruited to methylated ESR1 (Caenorhabditis elegans)
REACT:R-DRE-6784423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Danio rerio)
RHEA:47546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-hydroxy-D-proline betaine => trans-4-hydroxy-L-proline betaine
RHEA:40169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + H2O2 => hexadecanoyl-CoA + O2
REACT:R-HSA-3134904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser552 (Homo sapiens)
REACT:R-DDI-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Dictyostelium discoideum)
RHEA:32234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADPHX + ATP <=> ADP + H(+) + NADPH + phosphate
REACT:R-HSA-193761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)
REACT:R-CEL-8939706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) polyubiquitinates RUNX2 (Caenorhabditis elegans)
REACT:R-HSA-83790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Homo sapiens)
REACT:R-HSA-5690245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 binds DNAJB1 (Homo sapiens)
REACT:R-DRE-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Danio rerio)
REACT:R-DRE-2186643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEN1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)
REACT:R-HSA-947538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of sulfur from MOCS3-S-S onto MOCS2A (Homo sapiens)
REACT:R-DME-265645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Influx through Voltage-gated Calcium Channels (Drosophila melanogaster)
REACT:R-GGA-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Gallus gallus)
REACT:R-SSC-8955010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRTOMT transfers Met to DA, forming 3MT (Sus scrofa)
REACT:R-HSA-6800052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C binds the SCD gene (Homo sapiens)
RHEA:66382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycodeoxycholate(in) + H2O
REACT:R-HSA-448673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of caspase-1 p10/p20 dimer (Homo sapiens)
REACT:R-BTA-8876191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 GEFs exchange GTP for GDP on RAB9 (Bos taurus)
REACT:R-BTA-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)
REACT:R-DRE-426209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG activation of TRPC channels (Danio rerio)
REACT:R-DDI-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Dictyostelium discoideum)
RHEA:44189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-SPO-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Schizosaccharomyces pombe)
REACT:R-CFA-193787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Canis familiaris)
REACT:R-XTR-5671702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP1G2 binds HGS and CHMP2A (Xenopus tropicalis)
REACT:R-MMU-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Mus musculus)
REACT:R-XTR-5690042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)
RHEA:42232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-HSA-5607756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomer autoubiquitinates (Homo sapiens)
REACT:R-CFA-912527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
REACT:R-PFA-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Plasmodium falciparum)
REACT:R-DME-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Drosophila melanogaster)
REACT:R-CEL-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Caenorhabditis elegans)
REACT:R-CEL-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Caenorhabditis elegans)
RHEA:40886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2
RHEA:70717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(out) => glycine(in)
REACT:R-BTA-5686072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-3Y-SHC1 dissociates from IGF1R (Bos taurus)
RHEA:66303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)
REACT:R-DRE-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Danio rerio)
REACT:R-HSA-428885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of CLASP (Homo sapiens)
RHEA:19612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine
REACT:R-CFA-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Canis familiaris)
REACT:R-MMU-6788582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 phosphorylation (Mus musculus)
REACT:R-SSC-400204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds RXRA (Sus scrofa)
REACT:R-BTA-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Bos taurus)
REACT:R-DRE-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Danio rerio)
REACT:R-GGA-383313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like Peptide 1 is secreted from intestinal L cells (Gallus gallus)
REACT:R-RNO-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Rattus norvegicus)
REACT:R-DME-5693609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TP53 at S15 (Drosophila melanogaster)
REACT:R-MMU-9020273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Mus musculus)
REACT:R-MMU-4084980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Mus musculus)
RHEA:44632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dihydroxyphenyl)acetyl-CoA + O2 = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)
RHEA:44632	skos:prefLabel	"(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase"
RHEA:44632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase"
REACT:R-SSC-426223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cation influx mediated by TRPC3/6/7 (Sus scrofa)
RHEA:29569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(out) + H(+)(in) => 2 chloride(in) + H(+)(out)
REACT:R-CFA-9678935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Canis familiaris)
RHEA:62284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + L-proline + L-tryptophan + NADPH = (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)
REACT:R-BTA-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Bos taurus)
REACT:R-DRE-389354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Vav1 (Danio rerio)
REACT:R-BTA-8983371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Bos taurus)
REACT:R-DME-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
REACT:R-CFA-4568914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of BLM with SUMO2,3 (Canis familiaris)
REACT:R-DRE-8987040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Danio rerio)
GO:0045182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation factor activity
GO:0045182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation regulator activity
REACT:R-MMU-5690157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP16,USP21 deubiquitinate Histone H2A (Mus musculus)
GO:0005368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine transmembrane transporter activity
REACT:R-DRE-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Danio rerio)
GO:0086039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
GO:0086039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
RHEA:14816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-aminohexano-6-lactam <=> D-2-aminohexano-6-lactam
REACT:R-RNO-6784423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Rattus norvegicus)
REACT:R-HSA-9630047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective NTHL1 truncation mutants do not bind cytosine glycol (Cg) (Homo sapiens)
REACT:R-HSA-9638046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY3:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)
REACT:R-SCE-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Saccharomyces cerevisiae)
REACT:R-GGA-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Gallus gallus)
GO:0034852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-3-oxopentanal dehydrogenase activity
REACT:R-BTA-6809680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTM1 (Bos taurus)
REACT:R-RNO-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Rattus norvegicus)
REACT:R-BTA-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Bos taurus)
REACT:R-XTR-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Xenopus tropicalis)
RHEA:46254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:69891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + thymidine(out) = Na(+)(in) + thymidine(in)
RHEA:64157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-methionine + H2O => a fatty acid + L-methionine
REACT:R-DME-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Drosophila melanogaster)
REACT:R-GGA-190265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds to FGF (Gallus gallus)
REACT:R-CEL-6807008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates MET (Caenorhabditis elegans)
REACT:R-HSA-5633040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Homo sapiens)
REACT:R-CEL-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Caenorhabditis elegans)
REACT:R-SSC-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Sus scrofa)
RHEA:62796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + 2 rubrofusarin B = aurasperone A + 2 H2O + NADP(+)
REACT:R-HSA-8948536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTENP1 mRNA binds miR-20 RISC (Homo sapiens)
REACT:R-RNO-380901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked serotonin loaded synaptic vesicle (Rattus norvegicus)
REACT:R-SSC-9629195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Sus scrofa)
RHEA:63170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(2-succino)-L-cysteine => fumarate + L-cysteine
RHEA:51696	skos:prefLabel	"desmethylxanthohumol 6'-O-methyltransferase"
RHEA:51696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethylxanthohumol + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + xanthohumol
RHEA:51696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthogalenol = 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine
RHEA:51696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"desmethylxanthohumol 6'-O-methyltransferase"
RHEA:55113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)
REACT:R-MMU-392051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)
RHEA:33181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O
REACT:R-CFA-9676160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds NOD2 (Canis familiaris)
REACT:R-XTR-5626699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK4 binds ODF2 in the centriole (Xenopus tropicalis)
RHEA:29963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + inosine(in) = H(+)(out) + inosine(out)
REACT:R-BTA-71590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)
GO:0003684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	damaged DNA binding
GO:0003684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA repair protein
GO:0003684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA repair enzyme
REACT:R-CFA-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Canis familiaris)
RHEA:68353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pppA(2'-5')pG => 3',2'-cGAMP + diphosphate
GO:1990444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-box domain binding
REACT:R-RNO-9617370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-antagonists bind ADRA1A,B,D (Rattus norvegicus)
REACT:R-DDI-9693978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Small molecule inhibitor binds RIPK1, RIPK3 (Dictyostelium discoideum)
REACT:R-SSC-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Sus scrofa)
GO:0008919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity
GO:0008919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:lipopolysaccharide glucosyltransferase activity
GO:0008919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS glucosyltransferase I activity
GO:0008919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I
GO:0008919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:lipopolysaccharide glucosyltransferase activity
GO:0008919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide glucosyltransferase I activity
GO:0008919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipopolysaccharide glucosyltransferase activity
GO:0008919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:lipopolysaccharide glucosyltransferase I
REACT:R-XTR-8869603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A13 transports NCA from extracellular region to cytosol (Xenopus tropicalis)
RHEA:49505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphinomethylmalate => phosphinomethylisomalate
REACT:R-RNO-264678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Rattus norvegicus)
REACT:R-HSA-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Homo sapiens)
RHEA:51899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine <=> acetate + spermine
REACT:R-MMU-4086205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN (osteopontin) degradation by MMP3, MMP7 (Mus musculus)
REACT:R-CFA-71590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)
RHEA:49250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol 1-phosphate(in) + L-histidyl-[protein] => galactitol(out) + N(pros)-phospho-L-histidyl-[protein]
GO:0102479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-O-beta:-D-galactosyltransferase activity
REACT:R-HSA-168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNKs phosphorylate c-JUN (Homo sapiens)
REACT:R-DRE-1250348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by ERBB4 homodimers (Danio rerio)
REACT:R-GGA-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Gallus gallus)
REACT:R-SSC-166041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of LPS onto TLR4 (Sus scrofa)
REACT:R-HSA-428749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-proten Gq (Homo sapiens)
REACT:R-BTA-177924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Gab1 by SHP2 (Bos taurus)
RHEA:23111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinono-1,4-lactone + H2O <=> D-arabinonate + H(+)
RHEA:22985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + oxamate => N-carbamoyl-2-oxoglycine + phosphate
REACT:R-HSA-3858489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds DAAM1 (Homo sapiens)
REACT:R-CFA-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Canis familiaris)
RHEA:43954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate => 3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2
RHEA:18571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic carboxylate + H(+) + H2O2 => an aromatic aldehyde + H2O + O2
REACT:R-MMU-5432852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR4:LY96 (Mus musculus)
RHEA:21746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine
REACT:R-HSA-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Homo sapiens)
RHEA:43678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol
REACT:R-DRE-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Danio rerio)
REACT:R-SSC-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Sus scrofa)
REACT:R-RNO-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Rattus norvegicus)
REACT:R-HSA-1861789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Homo sapiens)
REACT:R-RNO-1449687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticosteroids bind to CBG in blood (Rattus norvegicus)
RHEA:30065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-8 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-8 + S-adenosyl-L-methionine
RHEA:61707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-serine <=> AMP + diphosphate + L-seryl-[peptidyl-carrier protein]
GO:0102763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + phytyl phosphate = a ribonucleoside 5'-diphosphate + phytyl diphosphate
GO:0102763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytyl-P kinase activity
RHEA:38558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an all-trans-retinyl ester + H2O <=> a fatty acid + all-trans-retinol + H(+)
REACT:R-MMU-9759202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Mus musculus)
REACT:R-BTA-2559639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV sulfilimine cross-linking by peroxidasin (Bos taurus)
REACT:R-SSC-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Sus scrofa)
REACT:R-HSA-2750177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-2 binds TRAPPC4 (Homo sapiens)
REACT:R-DRE-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Danio rerio)
RHEA:17954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde
GO:0070888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-box binding
GO:0070888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-box promoter binding
REACT:R-MMU-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Mus musculus)
EC:3.4.17.4	skos:prefLabel	"Gly-Xaa carboxypeptidase"
EC:3.4.17.4	skos:altLabel	"carboxypeptidase A"
EC:3.4.17.4	skos:altLabel	"glycine carboxypeptidase"
EC:3.4.17.4	skos:altLabel	"carboxypeptidase S"
EC:3.4.17.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Gly-Xaa carboxypeptidase"
EC:3.4.17.4	skos:altLabel	"Gly-X carboxypeptidase"
EC:3.4.22.33	skos:prefLabel	"fruit bromelain"
EC:3.4.22.33	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fruit bromelain"
REACT:R-SSC-4088024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Sus scrofa)
REACT:R-GGA-419334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melatonin receptors can bind melatonin (Gallus gallus)
REACT:R-CFA-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Canis familiaris)
RHEA:46588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcidiol + H2O + 2 oxidized [adrenodoxin]
GO:0004031	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	retinal oxidase activity
GO:0004031	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinoline oxidase activity
GO:0004031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde oxidase activity
GO:0004031	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde:oxygen oxidoreductase activity
REACT:R-CFA-1592398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP8 (Canis familiaris)
REACT:R-DRE-389463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteinase-activated receptors can bind thrombin (Danio rerio)
REACT:R-PFA-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Plasmodium falciparum)
REACT:R-HSA-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
REACT:R-HSA-2029992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants (Homo sapiens)
RHEA:18325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amorpha-4,11-diene synthase"
RHEA:18325	skos:prefLabel	"amorpha-4,11-diene synthase"
RHEA:18325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-amorpha-4,11-diene + diphosphate
RHEA:18325	skos:altLabel	"amorphadiene synthase"
REACT:R-HSA-164151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LKB1 phosphorylates the alpha subunit of AMPK heterotrimer (Homo sapiens)
RHEA:35473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-pisatin + H(+) + S-adenosyl-L-homocysteine => (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine
RHEA:35378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O <=> (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate
REACT:R-HSA-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Homo sapiens)
REACT:R-HSA-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Homo sapiens)
RHEA:25171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexan-6-olide <=> 6-oxohexanoate + H(+)
REACT:R-RNO-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Rattus norvegicus)
REACT:R-HSA-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Homo sapiens)
REACT:R-XTR-1433501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other adapter proteins with p-KIT (Xenopus tropicalis)
RHEA:49871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid + a quinone <=> (+)-dehydrodiconiferyl acid ketone + a quinol
RHEA:27697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O
GO:0004711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosomal protein S6 kinase activity
RHEA:18602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2
REACT:R-HSA-168882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of NP into rafts (Homo sapiens)
RHEA:56502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + isopentenyl phosphate + phosphate => (R)-3,5-bisphosphomevalonate + H(+)
REACT:R-DRE-174235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdc20 (Danio rerio)
REACT:R-MMU-2172123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SIGLEC14/15/16 and DAP12 (Mus musculus)
RHEA:72944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + pyruvate(out) => 2 Na(+)(in) + pyruvate(in)
REACT:R-RNO-2395768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPL hydrolyses TGs from mature CMs (Rattus norvegicus)
REACT:R-BTA-391211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trace amine-associated receptors can bind trace amines (Bos taurus)
RHEA:20373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"propionate--CoA ligase"
RHEA:20373	skos:prefLabel	"propionate--CoA ligase"
RHEA:20373	skos:altLabel	"propionyl-CoA synthetase"
RHEA:20373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA
REACT:R-MMU-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Mus musculus)
REACT:R-MMU-9708533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 translocates from the cytosol to the nucleoplasm (Mus musculus)
GO:0047093	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-H-4-oxoquinoline 3-monooxygenase activity
GO:0047093	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinolin-4(1H)-one 3-monooxygenase activity
GO:0047093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyquinoline 3-monooxygenase activity
GO:0047093	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)
RHEA:69787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminophenyl)succinate + succinyl-CoA = 3-(2-aminophenyl)succinyl-CoA + succinate
REACT:R-HSA-1368081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SREBF1 (SREBP1) (Homo sapiens)
REACT:R-SSC-1655831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 translocates to the nucleus (Sus scrofa)
REACT:R-HSA-1839102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA  (Homo sapiens)
REACT:R-GGA-9036301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Gallus gallus)
REACT:R-MMU-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Mus musculus)
REACT:R-SSC-4086205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN (osteopontin) degradation by MMP3, MMP7 (Sus scrofa)
RHEA:58338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-hydroxynonenal + H(+) + NADPH => a 4-hydroxynonen-1-ol + NADP(+)
REACT:R-DRE-1482868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Danio rerio)
REACT:R-MMU-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Mus musculus)
RHEA:28670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydroxyacetone + NADH <=> (S)-propane-1,2-diol + NAD(+)
REACT:R-HSA-8863494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASICs bind STOML3, (STOM) (Homo sapiens)
REACT:R-BTA-8932413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Bos taurus)
RHEA:45867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA
RHEA:39983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-CEL-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Caenorhabditis elegans)
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP17
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P45017alpha
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 17-alpha-hydroxylase-C17-20 lyase activity
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 17-alpha-hydroxylase activity
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 17alphahydroxylase/17,20 lyase activity
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 17-alpha-monooxygenase activity
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17alpha-hydroxylase-C17,20 lyase activity
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 17-alpha-hydroxylase/17,20 lyase activity
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 17alpha-hydroxylase activity
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P-450 (P-45017alpha,lyase)
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 17alpha-monooxygenase activity
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
GO:0004508	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome p450 XVIIA1 activity
REACT:R-GGA-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Gallus gallus)
RHEA:42811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite
REACT:R-GGA-6805792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S291-PHF20 translocates to cytosol (Gallus gallus)
REACT:R-CFA-8851900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1-2 bound to MET recruits GRB2:SOS1 (Canis familiaris)
REACT:R-RNO-6792863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PP2R5C dephosphorylates MDM2 (Rattus norvegicus)
REACT:R-CFA-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Canis familiaris)
RHEA:70875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-methionine(out) + Na(+)(out) = L-glutamine(out) + L-methionine(in) + Na(+)(in)
RHEA:35745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + NADP(+) + versicolorin A => H(+) + NADPH + O2 + versicolorin B
REACT:R-BTA-68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Bos taurus)
REACT:R-DME-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)
RHEA:25551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate <=> abieta-8(14),12-diene + diphosphate
REACT:R-RNO-141431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)
RHEA:10065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine
RHEA:34398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine <=> L-beta-phenylalanine
REACT:R-DDI-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Dictyostelium discoideum)
REACT:R-RNO-9015111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors binds Xa (Rattus norvegicus)
GO:0004535	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2',3'-exoribonuclease activity
GO:0004535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(A)-specific RNase activity
GO:0004535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(A)-specific ribonuclease activity
GO:0004535	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-exoribonuclease activity
RHEA:20236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7beta-hydroxysteroid + NADP(+) <=> a 7-oxosteroid + H(+) + NADPH
RHEA:47636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine + NADP(+) = 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)
REACT:R-XTR-9646685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggresome dissociates from dynein and microtubule (Xenopus tropicalis)
RHEA:24450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoglucosyl-enterobactin + UDP => enterobactin + UDP-alpha-D-glucose
REACT:R-HSA-6785895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of IL4, IL13-upregulated extracellular proteins (Homo sapiens)
REACT:R-CFA-8952903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRHL2 hydrolyses poly(ADP-ribose) (Canis familiaris)
REACT:R-DME-5696872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates Ub-MOM proteins (Drosophila melanogaster)
RHEA:57196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein]
RHEA:32705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycopalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O
RHEA:48372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)
RHEA:46864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
REACT:R-HSA-9623366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the MYLIP gene (Homo sapiens)
REACT:R-GGA-2730837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-10Y-NTAL (Gallus gallus)
RHEA:29274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + H(+) + trimethylamine N-oxide <=> a menaquinone + H2O + trimethylamine
RHEA:63063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylorsellinate + ATP + H(+) + NADPH <=> 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)
RHEA:49419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-ribose 1-phosphate <=> alpha-D-ribose 1,5-bisphosphate + AMP + H(+)
REACT:R-RNO-9021357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCI phosphorylates ELF3 (Rattus norvegicus)
REACT:R-DRE-5638007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 activates the GTPase activity of ARL3 (Danio rerio)
REACT:R-HSA-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)
REACT:R-XTR-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Xenopus tropicalis)
REACT:R-RNO-9619376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK1 binds calmodulin (Rattus norvegicus)
REACT:R-CFA-453339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)
RHEA:37440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
REACT:R-GGA-140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor V -> factor Va + factor V activation peptide (Gallus gallus)
RHEA:63859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecanoate <=> (2R)-2-hydroperoxytetradecanoate
REACT:R-MMU-8850529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGS proteins bind GNB5 and CCT/TRiC (Mus musculus)
RHEA:72536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + vanillin => 2 H(+) + NADPH + vanillate
RHEA:44317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoylglycerol + H2O => dodecanoate + glycerol + H(+)
RHEA:30482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]
GO:0004931	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	purinoceptor
GO:0004931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellularly ATP-gated cation channel activity
GO:0004931	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P2X receptor
GO:0004931	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	purinoreceptor
GO:0004931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates loss of intracellular K+ (Homo sapiens)
REACT:R-DRE-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Danio rerio)
RHEA:62300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)
GO:0043729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
REACT:R-HSA-983700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds the activated BCR (Homo sapiens)
REACT:R-GGA-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Gallus gallus)
RHEA:70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(in) + Na(+)(in) => D-glucose(out) + Na(+)(out)
REACT:R-MMU-6806610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filament formation (Mus musculus)
REACT:R-SCE-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)
RHEA:67093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + docosanoate(in) + H2O => ADP + docosanoate(out) + H(+) + phosphate
REACT:R-DRE-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Danio rerio)
REACT:R-DME-9029561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to the ABCA1 promoter (Drosophila melanogaster)
RHEA:64685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-alpha-D-glucose => 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP
REACT:R-HSA-5662908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopaquinone, cysteine form CD isomers (Homo sapiens)
RHEA:54946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+) => 3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH
REACT:R-RNO-8983845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dissociates from IL6ST:IL6ST (Rattus norvegicus)
REACT:R-HSA-159826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Homo sapiens)
REACT:R-DRE-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Danio rerio)
REACT:R-DRE-389826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NADPH + H+ => glycolate + NADP+ (Danio rerio)
RHEA:37971	skos:prefLabel	"stearoyl-CoA 9-desaturase (NADPH)"
RHEA:37971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stearoyl-CoA 9-desaturase (NADPH)"
RHEA:37971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)
REACT:R-HSA-9007647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds CBX5 gene promoter (Homo sapiens)
REACT:R-MMU-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)
REACT:R-SSC-6788571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 bind IL13:IL13R type II (Sus scrofa)
RHEA:52829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 => (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)
REACT:R-DRE-3858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL recruits RAC (Danio rerio)
REACT:R-MMU-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Mus musculus)
REACT:R-MMU-9009308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 polyubiquitinates RUNX2 (Mus musculus)
RHEA:66126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate => 2-oxobutanoate + L-histidine
REACT:R-RNO-193696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Rattus norvegicus)
RHEA:41020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-BTA-9619756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2 binds ABCA1 (Bos taurus)
REACT:R-HSA-9031807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protectins translocate from cytosol to extracellular region (Homo sapiens)
RHEA:32628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
RHEA:21006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantolactone + AH2 => (R)-pantolactone + A
REACT:R-BTA-8987104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Bos taurus)
RHEA:43046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octadecanoylhexadecasphinganine => hexadecasphinganine + octadecanoyl-CoA
REACT:R-RNO-8855111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds PCSK9 (Rattus norvegicus)
REACT:R-SSC-8954262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Sus scrofa)
RHEA:35836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-dehydrokanamycin A + H(+) + NADPH => kanamycin A + NADP(+)
REACT:R-RNO-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Rattus norvegicus)
RHEA:34402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone
RHEA:55734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]
RHEA:32062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O <=> (R)-glycerate + D-glucose
GO:0034548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-cyclopropylammeline deaminase activity
REACT:R-RNO-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)
REACT:R-HSA-9692134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FGF9 in testis differentiation (Homo sapiens)
RHEA:64220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine
RHEA:51438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-amino-4-oxopentanoate + CoA => acetyl-CoA + D-alanine
REACT:R-DRE-8864569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds TFAP2C (Danio rerio)
RHEA:23521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + propanoate => acetate + propanoyl-CoA
RHEA:33075	skos:altLabel	"aminofutalosine synthase"
RHEA:33075	skos:altLabel	"AFL synthase"
RHEA:33075	skos:prefLabel	"aminodeoxyfutalosine synthase"
RHEA:33075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminodeoxyfutalosine synthase"
RHEA:33075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine
GO:0102250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linear malto-oligosaccharide phosphorylase activity
RHEA:10699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + holo-[mycocerosate synthase] <=> AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]
RHEA:39398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)
REACT:R-HSA-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Homo sapiens)
REACT:R-CFA-397835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:Gq (active) dissociate (Canis familiaris)
RHEA:60931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Bos taurus)
REACT:R-SCE-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Saccharomyces cerevisiae)
REACT:R-DME-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Drosophila melanogaster)
REACT:R-BTA-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Bos taurus)
RHEA:70571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + Na(+)(out) = D-glucose(in) + Na(+)(in)
REACT:R-RNO-5654705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
GO:0047442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C-17/C-20 lyase activity
GO:0047442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17alpha-hydroxyprogesterone aldolase activity
GO:0047442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17alpha-hydroxyprogesterone acetaldehyde-lyase activity
GO:0047442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-alpha-hydroxyprogesterone aldolase activity
GO:0047442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17-alpha-hydroxyprogesterone acetaldehyde-lyase activity
GO:0047442	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)
REACT:R-HSA-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Homo sapiens)
RHEA:23709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)
REACT:R-HSA-8932070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds the AXIN1 gene (Homo sapiens)
REACT:R-DME-3249371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylates STAT6 at Ser407 (Drosophila melanogaster)
REACT:R-BTA-9018894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Bos taurus)
RHEA:59097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoglucosyl-enterobactin + UDP-alpha-D-glucose => diglucosyl-enterobactin + H(+) + UDP
GO:0010341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin carboxyl-O-methyltransferase activity
REACT:R-DRE-158860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates NHABP (Danio rerio)
RHEA:57475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + UDP-alpha-D-glucose <=> 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP
RHEA:21824	skos:altLabel	"aspartate aminotransferase"
RHEA:21824	skos:altLabel	"glutamic--oxaloacetic transaminase"
RHEA:21824	skos:prefLabel	"aspartate transaminase"
RHEA:21824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate
RHEA:21824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate transaminase"
RHEA:21824	skos:altLabel	"glutamic--aspartic transaminase"
RHEA:21824	skos:altLabel	"transaminase A"
REACT:R-RNO-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Rattus norvegicus)
RHEA:19782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3,5-diiodo-L-tyrosine => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate
REACT:R-SSC-171106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex => LDLR + LDL (Sus scrofa)
REACT:R-DME-5624951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNPO1 binds KIF17 dimer (Drosophila melanogaster)
REACT:R-HSA-5685242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates BRCA2 (Homo sapiens)
REACT:R-XTR-5654565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Xenopus tropicalis)
RHEA:25619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + terpentetriene => terpentedienyl diphosphate
RHEA:70770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-2730900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to pUb-TRAF6 (Rattus norvegicus)
RHEA:40650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)
RHEA:20788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + phosphate = ADP-beta-D-ribose 1''-phosphate + H(+) + nicotinamide
REACT:R-MMU-9010872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 binds Dystroglycan (Mus musculus)
REACT:R-MMU-6788571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 bind IL13:IL13R type II (Mus musculus)
RHEA:64811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + O-(2-aminoethyl)-L-serine <=> CoA + H(+) + O-(2-acetamidoethyl)-L-serine
REACT:R-BTA-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Bos taurus)
GO:0050634	skos:prefLabel	"phloroisovalerophenone synthase"
GO:0050634	skos:altLabel	"3-methyl-1-(trihydroxyphenyl)butan-1-one synthase"
GO:0050634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valerophenone synthase activity
GO:0050634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isovaleryl-CoA:malonyl-CoA acyltransferase activity
GO:0050634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phloroisovalerophenone synthase activity
GO:0050634	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity
GO:0050634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phloroisovalerophenone synthase"
GO:0050634	skos:altLabel	"acylphloroglucinol synthase"
GO:0050634	skos:altLabel	"valerophenone synthase"
REACT:R-BTA-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Bos taurus)
RHEA:58699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + rifampicin <=> H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide
RHEA:59753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]
REACT:R-SSC-446077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP230 interacts with keretin K5/K14 (Sus scrofa)
RHEA:48367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
REACT:R-DRE-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Danio rerio)
RHEA:56758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DDI-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)
REACT:R-DME-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Drosophila melanogaster)
REACT:R-HSA-5617410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R binds the GLI2 promoter (Homo sapiens)
REACT:R-CFA-170131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Canis familiaris)
RHEA:54134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+) => a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate
RHEA:61419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol <=> cis-trans-nepetalactol
REACT:R-RNO-2465934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL translocates from Muller cells to cone photoreceptor cells (Rattus norvegicus)
REACT:R-SSC-3222593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B demethylates H3K27me3 on p16INK4A promoter (Sus scrofa)
REACT:R-CFA-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Canis familiaris)
RHEA:27349	skos:prefLabel	"arsenate-mycothiol transferase"
RHEA:27349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arsenate-mycothiol transferase"
RHEA:27349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate + mycothiol = arseno-mycothiol + H2O
RHEA:51364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine
REACT:R-MMU-5684273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Mus musculus)
REACT:R-RNO-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)
RHEA:54644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-4-hydroxy-L-proline dehydratase"
RHEA:54644	skos:prefLabel	"trans-4-hydroxy-L-proline dehydratase"
RHEA:54644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H(+) + H2O
RHEA:24453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-[protein] + S-adenosyl-L-methionine => [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine
RHEA:68826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-beta-ocimene + diphosphate => (2E)-geranyl diphosphate
REACT:R-RNO-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Rattus norvegicus)
RHEA:58832	skos:prefLabel	"plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase"
RHEA:58832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
RHEA:58832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase"
RHEA:71523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine(out) = adenine(in)
REACT:R-HSA-204850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Dok-2 (Homo sapiens)
GO:0015310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benomyl:proton antiporter activity
GO:0015310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benomyl:hydrogen antiporter activity
RHEA:53083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-CFA-9712210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Canis familiaris)
GO:0004932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mating-type factor pheromone receptor activity
REACT:R-DRE-9611852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB3 bind ADR,NAd (Danio rerio)
RHEA:38386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)
RHEA:37959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-DME-173481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Drosophila melanogaster)
RHEA:42668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnofuranose + NADP(+) = H(+) + L-rhamnono-1,4-lactone + NADPH
RHEA:42668	skos:prefLabel	"L-rhamnose 1-dehydrogenase (NADP(+))"
RHEA:42668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-rhamnose 1-dehydrogenase (NADP(+))"
REACT:R-CEL-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Caenorhabditis elegans)
REACT:R-CEL-8867044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)
RHEA:19888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + O2 <=> (S)-scoulerine + H(+) + H2O2
RHEA:15091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + pyruvate => (R)-lactate + A
REACT:R-CFA-6787540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUK phosphorylates beta-Fuc to Fuc1P (Canis familiaris)
REACT:R-XTR-9696323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNRs bind CNR agonists (Xenopus tropicalis)
RHEA:44931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoheptanedioate + acetyl-CoA + H2O <=> (R)-trihomocitrate + CoA + H(+)
RHEA:46937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) => ATP + H(+) + L-2-aminoadipate + NADPH
RHEA:71022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + L-valine(in) <=> L-phenylalanine(in) + L-valine(out)
REACT:R-CEL-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Caenorhabditis elegans)
GO:0015612	skos:altLabel	"L-arabinose transporting ATPase"
GO:0015612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type L-arabinose transporter activity
GO:0015612	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-arabinose-importing ATPase activity
GO:0015612	skos:altLabel	"L-arabinose ABC transporter"
GO:0015612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinose porter activity
GO:0015612	skos:prefLabel	"ABC-type L-arabinose transporter"
GO:0015612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type L-arabinose transporter"
REACT:R-SSC-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Sus scrofa)
REACT:R-HSA-110355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MUTYH glycosylase by APEX1 at the AP site (Homo sapiens)
REACT:R-DRE-8848873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARAP1 (Danio rerio)
RHEA:33260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminoimidazole + H(+) + 2 H2O => N-formimidoylglycine + NH4(+)
RHEA:43214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine
REACT:R-XTR-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Xenopus tropicalis)
RHEA:67758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-MMU-1022133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Mus musculus)
RHEA:46409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:59955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dimethylheptanoyl-CoA + H2O <=> 2,6-dimethylheptanoate + CoA + H(+)
REACT:R-BTA-388605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMC(138-176) binds MC2R (Bos taurus)
RHEA:69957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(out) + 3 Na(+)(in) => Ca(2+)(in) + 3 Na(+)(out)
RHEA:56998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apulose => aldehydo-D-apiose
RHEA:47167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxyzymosterol + NAD(+) <=> CO2 + NADH + zymosterone
REACT:R-BTA-159843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)
REACT:R-CEL-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Caenorhabditis elegans)
RHEA:45638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O
REACT:R-GGA-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Gallus gallus)
REACT:R-CEL-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Caenorhabditis elegans)
GO:0045569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apo-2L binding
GO:0045569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL binding
REACT:R-HSA-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Homo sapiens)
REACT:R-BTA-749448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)
REACT:R-DME-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Drosophila melanogaster)
GO:0016402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Homo sapiens)
GO:0016402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanoyl-CoA oxidase activity
RHEA:48022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose => globoside Gb3Cer + H2O
REACT:R-BTA-5635861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH binds GLI1 (Bos taurus)
REACT:R-XTR-2161961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EET(1) is hydrolysed to DHET(1) by EPHX2 (Xenopus tropicalis)
RHEA:39937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O
RHEA:62131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + dGTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dGDP
RHEA:34122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA
RHEA:51238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate => GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-SSC-2408524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Sus scrofa)
REACT:R-XTR-5668454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Xenopus tropicalis)
GO:0043896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan-1,6-alpha-glucosidase activity
GO:0043896	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glucodextrinase
GO:0043896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan 1,6-alpha-glucosidase activity
GO:0043896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucan alpha-1,6-D-glucohydrolase activity
GO:0043896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,6-alpha-glucosidase activity
GO:0043896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucodextranase activity
GO:0043896	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,6-beta-glucosidase
RHEA:41579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-mycarose + erythronolide B <=> 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)
RHEA:18063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
REACT:R-MMU-5694445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH1 binds TFGA and AREG precursors (Mus musculus)
RHEA:26143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)
REACT:R-RNO-9638097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)
RHEA:12380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2,4-diaminobutanoate + pyruvate = L-alanine + L-aspartate 4-semialdehyde
RHEA:12380	skos:altLabel	"diaminobutyrate--pyruvate aminotransferase"
RHEA:12380	skos:altLabel	"L-diaminobutyric acid transaminase"
RHEA:12380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diaminobutyrate--pyruvate transaminase"
RHEA:12380	skos:prefLabel	"diaminobutyrate--pyruvate transaminase"
RHEA:42272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA
REACT:R-DRE-5686704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates DCLRE1C (Danio rerio)
REACT:R-SSC-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Sus scrofa)
REACT:R-CFA-1592316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP1 (Canis familiaris)
REACT:R-SSC-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Sus scrofa)
RHEA:35626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate + D-glutamine <=> gamma-D-glutamyl-D-glutamate + NH4(+)
EC:2.7.9.-	skos:prefLabel	"Phosphotransferases with paired acceptors"
EC:2.7.9.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphotransferases with paired acceptors"
EC:1.16.99.-	skos:prefLabel	"With other acceptors"
EC:1.16.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
RHEA:62960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)
REACT:R-SSC-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)
REACT:R-XTR-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Xenopus tropicalis)
RHEA:19963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside => a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate
RHEA:58032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-141202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates TYR (Homo sapiens)
REACT:R-BTA-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Bos taurus)
RHEA:29958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + thymidine(in) <=> H(+)(out) + thymidine(out)
REACT:R-DRE-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Danio rerio)
RHEA:69156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermine dialdehyde = acrolein + N-(4-aminobutyl)-3-aminopropanal
RHEA:68163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5660910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)
RHEA:11885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + cortisol => adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)
GO:0042975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisome proliferator activated receptor binding
GO:0042975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPAR binding
RHEA:57521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9762102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 binds the NFE2L2 promoter (Homo sapiens)
REACT:R-CFA-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Canis familiaris)
REACT:R-HSA-175976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMT transfers CH3 from AdoMet to BME (Homo sapiens)
RHEA:25872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + pyridine = H2O + pyridine N-oxide
REACT:R-DME-2090043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(7) (Drosophila melanogaster)
REACT:R-DDI-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Dictyostelium discoideum)
RHEA:28134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase"
RHEA:28134	skos:prefLabel	"hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase"
RHEA:28134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hesperidin + H2O = (2S)-hesperetin + rutinose
GO:0015092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity ferric iron transmembrane transporter activity
GO:0015092	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	high affinity ferric uptake transmembrane transporter activity
REACT:R-SCE-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Saccharomyces cerevisiae)
REACT:R-GGA-9034714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3 dimers trans-autophosphorylate (Gallus gallus)
REACT:R-HSA-1605768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Homo sapiens)
RHEA:69153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermine monoaldehyde => acrolein + spermidine
RHEA:58775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)
RHEA:43190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2634) in 25S rRNA
REACT:R-HSA-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)
REACT:R-GGA-216723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Gallus gallus)
REACT:R-SSC-5665999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 translocates from cytosol to the nucleus (Sus scrofa)
RHEA:17098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate => enol-phenylpyruvate
REACT:R-CFA-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Canis familiaris)
REACT:R-SSC-5661124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR4-HIST1H4 (Sus scrofa)
GO:0042296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)
GO:0042296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISG15 transferase activity
GO:0042296	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ISG15 conjugating enzyme activity
RHEA:48341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + ATP + CoA => a medium-chain fatty acyl-CoA + AMP + diphosphate
RHEA:66252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + IC-asc-C7 = AMP + diphosphate + IC-asc-C7-CoA
RHEA:67000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisobutanophenone
RHEA:19523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + CoA => acetyl-CoA + phosphate
RHEA:23561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate => adenosylcob(III)alamin 5'-phosphate + GMP + H(+)
REACT:R-SSC-196402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Sus scrofa)
REACT:R-XTR-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Xenopus tropicalis)
REACT:R-SSC-5675373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear DUSPs dephosphorylate MAPKs (Sus scrofa)
RHEA:68460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a phenolic steroid = a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:68460	skos:prefLabel	"steroid sulfotransferase"
RHEA:68460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steroid sulfotransferase"
RHEA:43444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-ditetradecanoyl-sn-glycerol + ATP = 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)
RHEA:32539	skos:prefLabel	"(+)-car-3-ene synthase"
RHEA:32539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-car-3-ene synthase"
RHEA:32539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (+)-car-3-ene + diphosphate
RHEA:32539	skos:altLabel	"3-carene cyclase"
GO:0031815	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P2Y5 nucleotide receptor ligand
GO:0031815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y5 nucleotide receptor binding
REACT:R-HSA-9636240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPE2 binds NOS2 gene (Homo sapiens)
RHEA:18798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-2514772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Caenorhabditis elegans)
REACT:R-HSA-373714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-Heterodimerization of nephrin and KIRREL (Homo sapiens)
REACT:R-DME-5654592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
RHEA:24073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O
RHEA:55297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + hexadecanoyl-CoA => 13-cis-retinyl hexadecanoate + CoA
EC:4.2.2.14	skos:prefLabel	"glucuronan lyase"
EC:4.2.2.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronan lyase"
RHEA:42456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methylzymosterol = zymosterol
RHEA:60196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate
REACT:R-MMU-6785126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA core complex assembles at DNA interstrand crosslinks (ICLs) (Mus musculus)
REACT:R-DRE-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Danio rerio)
REACT:R-DRE-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Danio rerio)
RHEA:31225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + cis-2-coumarate => cis-beta-D-glucosyl-2-hydroxycinnamate + H2O
REACT:R-DRE-2213235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of nonameric complex in the endocytic pathway (Danio rerio)
REACT:R-HSA-1013881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cables1 links CDK2 and WEE1 (Homo sapiens)
RHEA:49253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] => D-fructose 1-phosphate(in) + L-histidyl-[protein]
EC:1.2.1.9	skos:altLabel	"triosephosphate dehydrogenase"
EC:1.2.1.9	skos:prefLabel	"glyceraldehyde-3-phosphate dehydrogenase (NADP(+))"
EC:1.2.1.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyceraldehyde-3-phosphate dehydrogenase (NADP(+))"
RHEA:66783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O <=> N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate
GO:1990381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deubiquitinating enzyme binding
GO:1990381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-specific protease binding
GO:1990381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deubiquitinase binding
RHEA:45964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O = 2 AMP + ATP + 2 H(+)
RHEA:58916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene = (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-DRE-9603302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (peptide) binds IIa (Danio rerio)
REACT:R-HSA-8950453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Homo sapiens)
REACT:R-SSC-9620456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sGC stimulators bind sGC:NO (Sus scrofa)
RHEA:47156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,25-dihydroxycholesterol + NAD(+) = 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH
RHEA:39943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA
RHEA:24187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2
RHEA:63796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate
RHEA:63305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate
REACT:R-BTA-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Bos taurus)
RHEA:56411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-8987033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Homo sapiens)
GO:0051059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB binding
RHEA:33619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA
RHEA:72039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate(in) + orotate(out) = nicotinate(out) + orotate(in)
RHEA:60699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lavandulyl diphosphate + H2O <=> (R)-lavandulol + diphosphate
RHEA:31805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP => H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose
RHEA:66101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + L-kynurenine => H2O + kynurenate + L-tyrosine
RHEA:55538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose
REACT:R-HSA-8877192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds FOXP3 (Homo sapiens)
REACT:R-DRE-3640862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase binds AXIN (Danio rerio)
GO:0005044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scavenger receptor activity
GO:0005044	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	macrophage receptor activity
RHEA:71719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) = H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)
REACT:R-MMU-158340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Mus musculus)
REACT:R-SSC-2022403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)
REACT:R-RNO-6807206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 and OTUD3 deubiquitinate PTEN (Rattus norvegicus)
RHEA:36950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA
RHEA:71389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate(out) + Na(+)(out) => L-pipecolate(in) + Na(+)(in)
RHEA:44333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanine + L-anticapsin => ADP + bacilysin + H(+) + phosphate
REACT:R-MMU-3928612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KALRN exchanges GTP for GDP on RAC1, activating it (Mus musculus)
REACT:R-SSC-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Sus scrofa)
REACT:R-HSA-8944352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF/LEF binds WNT promoters (Homo sapiens)
REACT:R-RNO-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Rattus norvegicus)
RHEA:60350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine
GO:0051766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol trisphosphate kinase activity
RHEA:42602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + prostaglandin H2 => AH2 + prostaglandin G2
REACT:R-RNO-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
REACT:R-RNO-5676599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF trimer binds BAFFR (Rattus norvegicus)
RHEA:42304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
REACT:R-RNO-8852509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL-LK binds carbohydrates on target cell surface (Rattus norvegicus)
RHEA:44717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-4,4'-diapolycopen-4-al + H2O => AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)
REACT:R-HSA-5688786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds RAD23 (Homo sapiens)
GO:0071933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arp2/3 complex binding
REACT:R-BTA-5649725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Bos taurus)
GO:0018788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"atrazine chlorohydrolase"
GO:0018788	skos:prefLabel	"atrazine chlorohydrolase"
GO:0018788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrazine + H2O = chloride + H(+) + hydroxyatrazine
GO:0018788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrazine chlorohydrolase activity
GO:0018788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AtzA
REACT:R-CEL-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Caenorhabditis elegans)
RHEA:56161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate => an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP
GO:0047763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity
GO:0047763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caffeate 3-O-methyltransferase activity
GO:0047763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + S-adenosyl-L-methionine = (E)-ferulate + H(+) + S-adenosyl-L-homocysteine
GO:0047763	skos:prefLabel	"caffeate O-methyltransferase"
GO:0047763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caffeate methyltransferase activity
GO:0047763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeate O-methyltransferase activity
GO:0047763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caffeate O-methyltransferase"
GO:0047763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity
REACT:R-CFA-3159253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAB adenosylates cob(I)alamin (Canis familiaris)
RHEA:13570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP
REACT:R-HSA-211924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4B1 12-hydroxylates ARA (Homo sapiens)
REACT:R-CEL-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Caenorhabditis elegans)
REACT:R-CEL-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Caenorhabditis elegans)
REACT:R-DRE-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Danio rerio)
REACT:R-HSA-375144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1:GFRalpha-1 with GDNF (Homo sapiens)
GO:0042897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polymyxin transporter activity
GO:0042897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polymyxin transmembrane transporter activity
REACT:R-DDI-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Dictyostelium discoideum)
GO:0046910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pectinesterase inhibitor activity
REACT:R-CFA-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Canis familiaris)
RHEA:20630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-[protein] => L-seryl-[protein] + phosphate
REACT:R-BTA-2018682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Bos taurus)
RHEA:43531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NAD(+) <=> 2-aminomalonate semialdehyde + H(+) + NADH
REACT:R-RNO-2299620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen XI cross-links with collagen II (Rattus norvegicus)
RHEA:21374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + ethanol + NH4(+) => H(+) + H2O + urethane
REACT:R-HSA-9619430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1E dephosphorylates CAMK4 (Homo sapiens)
RHEA:37403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA
GO:0009035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonuclease (adenosine triphosphate-hydrolyzing)
GO:0009035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent DNase activity
GO:0009035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine triphosphate-dependent deoxyribonuclease activity
GO:0009035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I restriction enzyme activity
GO:0009035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I site-specific deoxyribonuclease activity
GO:0009035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)
RHEA:42482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+) => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O
RHEA:39222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctacosanyol-CoA + H(+) + NADPH <=> (3R)-hydroxyoctacosanoyl-CoA + NADP(+)
RHEA:50247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-451826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YKI binds to EX (Drosophila melanogaster)
RHEA:39104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sitosterol(in) => ADP + H(+) + phosphate + sitosterol(out)
REACT:R-MMU-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Mus musculus)
RHEA:20363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-9008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37, IL37(?-218) translocates from cytosol to extracellular region (Canis familiaris)
RHEA:40786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + H2O <=> CoA + docosanoate + H(+)
RHEA:61070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-O-acetylhorhammericine + CoA => acetyl-CoA + horhammericine
EC:2.6.1.82	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"putrescine--2-oxoglutarate transaminase"
EC:2.6.1.82	skos:altLabel	"putrescine transaminase"
EC:2.6.1.82	skos:altLabel	"putrescine aminotransferase"
EC:2.6.1.82	skos:altLabel	"PAT"
EC:2.6.1.82	skos:altLabel	"putrescine-alpha-ketoglutarate transaminase"
EC:2.6.1.82	skos:prefLabel	"putrescine--2-oxoglutarate transaminase"
REACT:R-CEL-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Caenorhabditis elegans)
REACT:R-CFA-76416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Benzene is hydroxylated to phenol (Canis familiaris)
RHEA:25957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3-dehydroquinate + H(+) + NADH + NH4(+)
REACT:R-HSA-6800298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF dimer binds MET (Homo sapiens)
RHEA:17288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP
GO:0044683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiol:coenzyme M methyl transferase activity
GO:0044683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiol:coenzyme M methyltransferase activity
RHEA:42451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O
REACT:R-HSA-71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Homo sapiens)
REACT:R-GGA-8950453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Gallus gallus)
REACT:R-SSC-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Sus scrofa)
REACT:R-SSC-8870346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Sus scrofa)
RHEA:65710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-galactose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-beta-L-galactose
RHEA:16560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-3-carboxymuconate 6-semialdehyde + H(+) <=> 2-aminomuconate 6-semialdehyde + CO2
RHEA:12366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + beta-nicotinamide D-riboside => 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+)
RHEA:40639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-RNO-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)
RHEA:39465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA
RHEA:65878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-5alpha-androstan-3,17-dione => 5alpha-androst-1-ene-3,17-dione + H2O
RHEA:69852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in mRNA + NAD(+) => a uridine in mRNA + H(+) + NADH
RHEA:52164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetonitrile alpha-monooxygenase"
RHEA:52164	skos:altLabel	"CYP3201B1"
RHEA:52164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:52164	skos:prefLabel	"phenylacetonitrile alpha-monooxygenase"
RHEA:28297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-(E)-beta-caryophyllene + diphosphate
RHEA:19969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxylamine oxidase (cytochrome)"
RHEA:19969	skos:altLabel	"hydroxylamine oxidase"
RHEA:19969	skos:prefLabel	"hydroxylamine oxidase (cytochrome)"
RHEA:19969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylamine + O2 = H(+) + H2O + nitrite
RHEA:19969	skos:altLabel	"hydroxylamine oxidoreductase"
RHEA:19969	skos:altLabel	"HAO"
RHEA:11337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine => deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine
RHEA:45548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]
RHEA:45548	skos:prefLabel	"R-phycocyanin alpha-cysteine-84 phycourobilin lyase/isomerase"
RHEA:45548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"R-phycocyanin alpha-cysteine-84 phycourobilin lyase/isomerase"
REACT:R-SSC-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Sus scrofa)
RHEA:11050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid => 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine
RHEA:12514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NH4(+) + oxaloacetate => D-aspartate + H2O + O2
REACT:R-XTR-419049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK activation by RHO (Xenopus tropicalis)
REACT:R-RNO-211923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)
RHEA:15384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + quercetin <=> 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
REACT:R-BTA-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Bos taurus)
REACT:R-XTR-158781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Xenopus tropicalis)
RHEA:33038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-GGA-8858428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FCAMR binds IgA (Gallus gallus)
RHEA:30267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 monodehydro-L-ascorbate radical = L-ascorbate + L-dehydroascorbate
GO:0052593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptamine:oxygen oxidoreductase (deaminating) activity
GO:0052593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + tryptamine <=> H2O2 + indole-3-acetaldehyde + NH4(+)
REACT:R-DRE-168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNKs phosphorylate c-JUN (Danio rerio)
REACT:R-CFA-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Canis familiaris)
REACT:R-GGA-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Gallus gallus)
RHEA:61589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amicoumacin A + ATP => ADP + amicoumacin A 2-phosphate + H(+)
GO:0003941	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	serine deaminase activity
GO:0003941	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine ammonia-lyase (pyruvate-forming) activity
GO:0003941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine deaminase activity
GO:0003941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine hydro-lyase (deaminating) activity
GO:0003941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine ammonia-lyase activity
GO:0003941	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-serine dehydratase activity
GO:0003941	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine dehydration activity
GO:0003941	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-hydroxyaminoacid dehydratase activity
GO:0031760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edg-7 lysophosphatidic acid receptor binding
GO:0031760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA3 receptor binding
GO:0031760	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Edg-7 lysophosphatidic acid receptor ligand
RHEA:55210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-hydroxyhexadecanal + phosphoethanolamine => (4R)-hydroxysphinganine 1-phosphate
REACT:R-CEL-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Caenorhabditis elegans)
RHEA:55025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-2750187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Danio rerio)
REACT:R-CEL-9613570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Caenorhabditis elegans)
RHEA:19713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arachidonate--CoA ligase"
RHEA:19713	skos:altLabel	"arachidonoyl-CoA synthetase"
RHEA:19713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
RHEA:19713	skos:prefLabel	"arachidonate--CoA ligase"
REACT:R-SSC-3361751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin is replaced by repression complexes at the promoter (Sus scrofa)
REACT:R-GGA-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Gallus gallus)
REACT:R-CEL-1614461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetramerization of procollagen VI (Caenorhabditis elegans)
RHEA:41657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + NADP(+) => NADPH + sanguinarine
RHEA:61225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-asparagine + O2 => 2-oxosuccinamate + H2O2 + NH4(+)
RHEA:59122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+)
RHEA:27444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + xylitol <=> D-xylose + H(+) + NADH
REACT:R-MMU-937311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP12A:ATP4B exchanges K+ for H+ (Mus musculus)
RHEA:35903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-9621042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TF gene expression (Homo sapiens)
GO:0019187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,4-mannosyltransferase activity
REACT:R-BTA-6803789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Bos taurus)
REACT:R-DRE-5690785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds Ub-HCFC1 (Danio rerio)
REACT:R-PFA-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Plasmodium falciparum)
REACT:R-HSA-110239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPG glycosylase mediated recognition and binding of ethenoadenine  (Homo sapiens)
RHEA:21658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-3,6-dideoxy-alpha-D-mannose => CDP-alpha-D-paratose
REACT:R-SPO-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Schizosaccharomyces pombe)
RHEA:66337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(out) => L-glutamate(in)
RHEA:15643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + pyruvate => H(+) + oxaloacetate
REACT:R-MMU-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)
REACT:R-XTR-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Xenopus tropicalis)
GO:0015211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine nucleoside transmembrane transporter activity
RHEA:71395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)
RHEA:70406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 3-oxosphinganine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine
REACT:R-HSA-982792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor binds JAK2 (Homo sapiens)
REACT:R-HSA-9023171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin secretory granule translocates across the cortical actin network (Homo sapiens)
REACT:R-HSA-9033520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves TYSND1 (Homo sapiens)
RHEA:31867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"baccharis oxide synthase"
RHEA:31867	skos:prefLabel	"baccharis oxide synthase"
RHEA:31867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = baccharis oxide
RHEA:29922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)
RHEA:11166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine
RHEA:54913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + NADP(+) => 11-cis-retinal + H(+) + NADPH
RHEA:22082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + quinoline-2,8-diol => H(+) + NADH + O2 + quinolin-2-ol
REACT:R-MMU-420598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:Nectin-4 trans heterodimer formation (Mus musculus)
RHEA:45981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)
RHEA:27862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-GMP + H2O = guanosine + phosphate
REACT:R-CEL-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Caenorhabditis elegans)
RHEA:61543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-399978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase C, alpha type phosphorylates MARCKS (Canis familiaris)
REACT:R-DME-2028692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK4 (p-MST1) by caspase 3 (Drosophila melanogaster)
REACT:R-SSC-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Sus scrofa)
RHEA:25239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CTP => ATP + CDP
RHEA:51023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + 2 Fe(III)-[cytochrome c] <=> an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-HSA-9697084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective rpoB in Mtb RNAP transcribes RNA polyanion (Homo sapiens)
RHEA:11580	skos:altLabel	"phosphatidylinositol synthase"
RHEA:11580	skos:altLabel	"CDP-diacylglycerol--inositol phosphatidyltransferase"
RHEA:11580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-diacylglycerol--inositol 3-phosphatidyltransferase"
RHEA:11580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)
RHEA:11580	skos:prefLabel	"CDP-diacylglycerol--inositol 3-phosphatidyltransferase"
REACT:R-HSA-2314678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS1 (Homo sapiens)
RHEA:29637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + D-maltotetraose => D-maltopentaose + H2O
RHEA:13012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-kynurenine <=> formate + H(+) + L-kynurenine
REACT:R-MMU-1112755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds IL6ST (Mus musculus)
REACT:R-RNO-350901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is organified (Rattus norvegicus)
RHEA:63281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)
GO:0050403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-zeatin O-beta-D-glucosyltransferase activity
GO:0050403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zeatin O-glucosyltransferase activity
GO:0050403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity
GO:0050403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zeatin O-beta-D-glucosyltransferase activity
GO:0050403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-zeatin O-glucosyltransferase activity
GO:0050403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zeatin O-b-D-glucosyltransferase activity
GO:0050403	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity
REACT:R-BTA-5654662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
REACT:R-RNO-9757954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4BP1 binds IKBKG (Rattus norvegicus)
RHEA:63591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin + UDP-alpha-D-glucuronate <=> prunetin-4'-O-beta-D-glucuronide + UDP
REACT:R-DRE-183122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3b-bound Factor B (Danio rerio)
RHEA:57204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + L-lysyl-[protein] = N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]
GO:0102788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity
REACT:R-DDI-9025999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Dictyostelium discoideum)
RHEA:35312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisoheptadecanoyl-CoA + NADP(+) => 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH
RHEA:59889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chloro-L-lysine + AH2 + O2 => A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)
REACT:R-DRE-182988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty lures CBL away from EGFR (Danio rerio)
REACT:R-HSA-9653503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B is phosphorylated on serine 181 (Homo sapiens)
RHEA:53051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone + UDP-alpha-D-glucuronate <=> 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-XTR-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Xenopus tropicalis)
RHEA:65458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutyl acetate + CoA => 2-methylbutan-1-ol + acetyl-CoA
RHEA:21627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NADP(+) <=> FMN + 2 H(+) + NADPH
REACT:R-MMU-909724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IFNAR1 (Mus musculus)
RHEA:13207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-monosaccharide + diphosphate => a monosaccharide 1-phosphate + H(+) + UTP
RHEA:66418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O
REACT:R-RNO-8850831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates KLK8 (Rattus norvegicus)
RHEA:54295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[protein] <=> 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate
REACT:R-CFA-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Canis familiaris)
REACT:R-XTR-8851679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR183 binds 7alpha,25-dihydroxycholesterol (Xenopus tropicalis)
RHEA:49048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]
REACT:R-CEL-203973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle budding (Caenorhabditis elegans)
RHEA:47945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => (2E)-geranyl phosphate + H(+) + phosphate
REACT:R-BTA-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Bos taurus)
REACT:R-CFA-200396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Creatine transport across the plasma membrane (Canis familiaris)
GO:0140819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-beta-L-arabinofuranose transporter activity
RHEA:45813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain (3R)-3-hydroxyacyl-CoA => a very-long-chain (2E)-enoyl-CoA + H2O
REACT:R-SSC-5368580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Sus scrofa)
RHEA:62089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucosamine 6-phosphate + NADP(+) => 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH
RHEA:57598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:44502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O
REACT:R-BTA-2404134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4:atROL binds TTR (Bos taurus)
REACT:R-BTA-6783552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSM binds LIFR:JAKs,OSMR:JAKs (Bos taurus)
GO:0051870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methotrexate binding
RHEA:64922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-diphosphate + H2O
RHEA:55394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in mRNA + S-adenosyl-L-methionine
RHEA:40479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:13180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-5-dehydro-2-deoxy-D-gluconate <=> 3-oxopropanoate + dihydroxyacetone phosphate
RHEA:70667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]
RHEA:16342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-phosphomevalonate + ATP => (R)-5-diphosphomevalonate + ADP
REACT:R-HSA-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Homo sapiens)
REACT:R-XTR-2168923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XVIII endostatin release (Xenopus tropicalis)
RHEA:52172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol
REACT:R-CFA-5690669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds itself to form homo-oligomers (Canis familiaris)
RHEA:20469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP = D-ribose 5-phosphate + hypoxanthine
RHEA:20469	skos:prefLabel	"inosinate nucleosidase"
RHEA:20469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inosinate nucleosidase"
REACT:R-BTA-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Bos taurus)
REACT:R-DME-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Drosophila melanogaster)
REACT:R-MMU-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Mus musculus)
REACT:R-SSC-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Sus scrofa)
RHEA:40124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine => 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine
RHEA:29019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out)
REACT:R-DDI-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Dictyostelium discoideum)
RHEA:36711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-ureido-D-serine cyclo-ligase"
RHEA:36711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + H2O + O-ureido-D-serine = ADP + CO2 + D-cycloserine + NH4(+) + phosphate
RHEA:36711	skos:prefLabel	"O-ureido-D-serine cyclo-ligase"
REACT:R-SSC-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Sus scrofa)
REACT:R-HSA-8950322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ribosomal protein lateral stalk subunit P0 (Homo sapiens)
REACT:R-HSA-2671862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 Phosphorylates IRS in Response to Leptin (Homo sapiens)
REACT:R-GGA-5226904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Gallus gallus)
GO:0102672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid alpha-oxygenase activity
REACT:R-GGA-446868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Interleukin 1 receptor complex binds Tollip (Gallus gallus)
REACT:R-HSA-9697043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protease binds protease inhibitors (Homo sapiens)
REACT:R-BTA-2872498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Bos taurus)
REACT:R-MMU-183002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Mus musculus)
REACT:R-CFA-5649681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL2 cleaves 5-OHU from damaged DNA (Canis familiaris)
RHEA:25714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:37879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aklanonic acid methyl ester cyclase"
RHEA:37879	skos:prefLabel	"aklanonic acid methyl ester cyclase"
RHEA:37879	skos:altLabel	"methyl aklanonate cyclase"
RHEA:37879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl aklanonate = aklaviketone
REACT:R-HSA-449073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-3 cleaves pro-interleukin-16 (Homo sapiens)
RHEA:11309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate
RHEA:16587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin] => [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine
RHEA:72434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + ATP + H(+) <=> (E)-caffeoyl-AMP + diphosphate
RHEA:16783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + CoA + H(+) => a fatty acyl-CoA + H2O
REACT:R-SCE-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Saccharomyces cerevisiae)
REACT:R-XTR-8851877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Xenopus tropicalis)
RHEA:21129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + zymosterol => fecosterol + H(+) + S-adenosyl-L-homocysteine
RHEA:47378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:33099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + spermine = CoA + H(+) + N(1)-acetylspermine
REACT:R-HSA-2400009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
REACT:R-DME-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Drosophila melanogaster)
EC:2.4.99.3	skos:altLabel	"GalNAc alpha-2,6-sialyltransferase I"
EC:2.4.99.3	skos:prefLabel	"alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase"
EC:2.4.99.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase"
REACT:R-GGA-204813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb14 (Gallus gallus)
REACT:R-HSA-170979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Frs2)C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)
REACT:R-RNO-202110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1 complex binds to CaM (Rattus norvegicus)
REACT:R-HSA-1253321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)
RHEA:52482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Bos taurus)
GO:0008035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-density lipoprotein particle binding
GO:0008035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDL binding
REACT:R-RNO-9681763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1 binds IL1R1 inhibitors (Rattus norvegicus)
REACT:R-DRE-4093329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SDCBP (Danio rerio)
REACT:R-DRE-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Danio rerio)
REACT:R-SSC-9027624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DHA to 7-HDHA (Sus scrofa)
RHEA:37423	skos:prefLabel	"aclacinomycin-N oxidase"
RHEA:37423	skos:altLabel	"AknOx"
RHEA:37423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin N + O2 = aclacinomycin A + H2O2
RHEA:37423	skos:altLabel	"aclacinomycin oxidoreductase"
RHEA:37423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aclacinomycin-N oxidase"
RHEA:41056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA
REACT:R-CFA-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Canis familiaris)
REACT:R-CFA-209859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decarboxylation of 5-hydroxytryptophan forms serotonin (Canis familiaris)
RHEA:41409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine
REACT:R-GGA-9657619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Gallus gallus)
RHEA:71199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(in) = L-ornithine(out)
REACT:R-SSC-6782106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates SNX3, CFTR (Sus scrofa)
REACT:R-BTA-77304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Bos taurus)
REACT:R-HSA-9619127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK4 binds KPNA2 (Homo sapiens)
REACT:R-HSA-390302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA (Homo sapiens)
REACT:R-XTR-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Xenopus tropicalis)
RHEA:25119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+) => H2O + L-lysine + NAD(+)
REACT:R-RNO-9706399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 hydrolyzes ATP (Rattus norvegicus)
RHEA:64347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 <=> 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)
RHEA:10005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl isothiocyanate => benzyl thiocyanate
RHEA:55268	skos:prefLabel	"glucosylglycerate phosphorylase"
RHEA:55268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosylglycerate phosphorylase"
RHEA:55268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate = (R)-glycerate + alpha-D-glucose 1-phosphate
REACT:R-HSA-6803403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCBP4 binds the CDKN1A mRNA (Homo sapiens)
REACT:R-RNO-9018859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Rattus norvegicus)
RHEA:40613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate => H2O + trihexanoylglycerol
REACT:R-GGA-9606894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DAPP1 (p-BAM32) binds PLCG2 (Gallus gallus)
REACT:R-PFA-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Plasmodium falciparum)
REACT:R-RNO-174587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Rattus norvegicus)
RHEA:21091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 <=> a flavonol + CO2 + H2O + succinate
RHEA:41533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine
REACT:R-RNO-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Rattus norvegicus)
RHEA:36143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + H(+) + NADPH = hexadecanoyl-CoA + NADP(+)
RHEA:36750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-XTR-6788556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to NDUFV1, V2 (Xenopus tropicalis)
REACT:R-HSA-2317530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum (Homo sapiens)
REACT:R-BTA-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Bos taurus)
RHEA:68311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate
REACT:R-GGA-606326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HJURP:CENPA complex localizes to the centromere (Gallus gallus)
RHEA:59124	skos:prefLabel	"L-2,3-diaminopropanoate--citrate ligase"
RHEA:59124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-2,3-diaminopropanoate--citrate ligase"
RHEA:59124	skos:altLabel	"2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate synthtase"
RHEA:59124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + ATP + citrate = 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate
RHEA:67688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O = 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate
REACT:R-XTR-2022381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)
REACT:R-HSA-9672162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)
RHEA:18453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O = [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate
RHEA:18453	skos:prefLabel	"ABC-type beta-glucan transporter"
RHEA:18453	skos:altLabel	"beta-glucan-transporting ATPase"
RHEA:18453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type beta-glucan transporter"
RHEA:15234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[cytochrome c] + H2O + nitric oxide => Fe(II)-[cytochrome c] + 2 H(+) + nitrite
REACT:R-BTA-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Bos taurus)
RHEA:72499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + prostaglandin E2(out) = 2-oxoglutarate(out) + prostaglandin E2(in)
REACT:R-RNO-1678944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Rattus norvegicus)
RHEA:30929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose => 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O
REACT:R-MMU-1482907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Mus musculus)
REACT:R-BTA-164832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase synthesizes ATP (Bos taurus)
RHEA:71510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-tocopherol(out) <=> (+)-alpha-tocopherol(in)
REACT:R-GGA-2534346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAM1 Binds Hyaluronic Acid (Gallus gallus)
RHEA:35207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IDP = H(+) + IMP + phosphate
REACT:R-HSA-9694718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-glycosylation of 3a is terminated (Homo sapiens)
RHEA:53711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + NADP(+) <=> (2E,4Z)-decadienoyl-CoA + H(+) + NADPH
RHEA:54547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine <=> 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-DRE-5658430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF1 is degraded by the proteasome (Danio rerio)
RHEA:59451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecan-1-ol + NADP(+) <=> dodecanal + H(+) + NADPH
GO:0005277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Homo sapiens)
GO:0005277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine transmembrane transporter activity
RHEA:27918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + propanal = 2 H(+) + NADPH + propanoate
RHEA:17826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucose => ADP + D-glucose 6-phosphate + H(+)
GO:0047691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity
GO:0047691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspulvinone dimethylallyltransferase activity
GO:0047691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity
REACT:R-BTA-2076383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3ST1 sulfates GlcN at C3 in heparan sulfate (Bos taurus)
RHEA:39912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-methylphenylalanine + 2-oxoglutarate => (3S)-2-oxo-3-phenylbutanoate + L-glutamate
REACT:R-BTA-5649854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to oxidatively damaged AP site (Bos taurus)
RHEA:53273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-L-gluconate => keto-D-tagaturonate
REACT:R-GGA-4085331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-1 SUMOylates PARK7 with SUMO1 (Gallus gallus)
REACT:R-SSC-163741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Sus scrofa)
GO:0102549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity
GO:0015451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decarboxylation-driven active transmembrane transporter activity
GO:0015451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	decarboxylation-driven transporter
RHEA:31283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + FADH2
RHEA:11918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin E2 + H(+) + NADH => 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+)
GO:0051991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity
REACT:R-RNO-156526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Rattus norvegicus)
GO:0034485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
RHEA:66648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = african-3-ene + diphosphate
GO:1990714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGT
GO:1990714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyproline O-galactosyltransferase activity
EC:2.6.1.42	skos:altLabel	"branched-chain amino acid aminotransferase"
EC:2.6.1.42	skos:prefLabel	"branched-chain-amino-acid transaminase"
EC:2.6.1.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"branched-chain-amino-acid transaminase"
EC:2.6.1.42	skos:altLabel	"transaminase B"
REACT:R-DRE-8987012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Danio rerio)
REACT:R-HSA-5483238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh processing variants are ubiquitinated (Homo sapiens)
REACT:R-SSC-8956684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH polyubiquitinates TP73 (Sus scrofa)
EC:1.1.99.40	skos:prefLabel	"(R)-2-hydroxyglutarate--pyruvate transhydrogenase"
EC:1.1.99.40	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-2-hydroxyglutarate--pyruvate transhydrogenase"
RHEA:48611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 2,3-saturated acyl-CoA <=> a 2,3-dehydroacyl-CoA + AH2
REACT:R-DRE-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Danio rerio)
GO:0050307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose-phosphate phosphatase activity
GO:0050307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose-6F-phosphate phosphohydrolase activity
GO:0050307	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose-phosphate phosphohydrolase activity
RHEA:71948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-aspartate(out) + 3 Na(+)(out) => N-acetyl-L-aspartate(in) + 3 Na(+)(in)
REACT:R-BTA-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Bos taurus)
RHEA:29257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(out) + Na(+)(in) => Ca(2+)(in) + Na(+)(out)
EC:1.14.14.173	skos:prefLabel	"2,4,6-trichlorophenol monooxygenase"
EC:1.14.14.173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4,6-trichlorophenol monooxygenase"
REACT:R-BTA-2465938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates atROL taken up by Muller cells (Bos taurus)
REACT:R-MMU-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Mus musculus)
RHEA:47101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + taurine => CoA + H(+) + taurocholate
RHEA:13815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => benzene + H(+) + NADH + O2
REACT:R-MMU-9668419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Mus musculus)
RHEA:60103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin + UDP-alpha-D-glucose <=> cyanidin 3-O-beta-D-glucoside + H(+) + UDP
GO:0034535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-8-methylnaphthalene dioxygenase activity
REACT:R-HSA-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Homo sapiens)
REACT:R-MMU-158781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Mus musculus)
RHEA:10302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + H(+) + NADH => D-glyceraldehyde 3-phosphate + NAD(+) + phosphate
REACT:R-DME-9674131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
REACT:R-BTA-5693608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial resection of double-strand break ends (Bos taurus)
REACT:R-CFA-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Canis familiaris)
REACT:R-HSA-4724330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALG8 does not add glucose to the N-glycan precursor (Homo sapiens)
RHEA:19906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + spermidine => dehydrospermidine + H(+) + NADH
REACT:R-SSC-2090037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(6) (Sus scrofa)
RHEA:66690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2
REACT:R-DRE-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)
GO:0106389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysteroid 22-kinase activity
REACT:R-HSA-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Homo sapiens)
REACT:R-DRE-5682802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI3 binds ADAM22,23,synatxin1 (Danio rerio)
REACT:R-HSA-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Homo sapiens)
REACT:R-DRE-380076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 1 (NK1) binds to substance P (Danio rerio)
RHEA:34267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumigaclavine B O-acetyltransferase"
RHEA:34267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A
RHEA:34267	skos:prefLabel	"fumigaclavine B O-acetyltransferase"
RHEA:29869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + IDP => AMP + ITP
RHEA:71859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate(out) = glycochenodeoxycholate(in)
REACT:R-GGA-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Gallus gallus)
RHEA:38626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:33052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + NAD(+) => betaine aldehyde + H(+) + NADH
RHEA:64520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA = A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde
RHEA:51695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prephenate + S-adenosyl-L-methionine <=> 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O
REACT:R-HSA-109449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Homo sapiens)
REACT:R-SCE-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Saccharomyces cerevisiae)
REACT:R-RNO-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)
RHEA:23684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methyltetrahydroprotoberberine 14-monooxygenase"
RHEA:23684	skos:altLabel	"methyltetrahydroprotoberberine 14-hydroxylase"
RHEA:23684	skos:altLabel	"(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase"
RHEA:23684	skos:prefLabel	"methyltetrahydroprotoberberine 14-monooxygenase"
RHEA:23684	skos:altLabel	"CYP82N4"
RHEA:23684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:13836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + pyruvate <=> 5-guanidino-2-oxopentanoate + L-alanine
REACT:R-HSA-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Homo sapiens)
REACT:R-HSA-8950225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Ras-related protein Rap-1b (Homo sapiens)
REACT:R-RNO-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)
REACT:R-SSC-174963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1 acetylation (Sus scrofa)
REACT:R-HSA-9010503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXA2 binds ROBO2 gene promoter (Homo sapiens)
REACT:R-SSC-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)
RHEA:52638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate => 2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2
GO:0047581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methylene-L-glutamate:ammonia ligase (AMP-forming)
GO:0047581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methyleneglutamine synthetase activity
GO:0047581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyleneglutamate-ammonia ligase activity
REACT:R-MMU-1614605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is dioxygenated (Mus musculus)
REACT:R-DRE-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Danio rerio)
RHEA:51487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Mus musculus)
REACT:R-HSA-1912362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR150 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)
RHEA:38809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:71791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate(in) + H(+)(in) = (R)-lactate(out) + H(+)(out)
GO:0033991	skos:altLabel	"1,5-anhydro-D-fructose dehydratase (microthecin-forming)"
GO:0033991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity
GO:0033991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AUDH
GO:0033991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldos-2-ulose dehydratase activity
GO:0033991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyranosone dehydratase activity
GO:0033991	skos:altLabel	"AUDH"
GO:0033991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldos-2-ulose dehydratase"
GO:0033991	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity
GO:0033991	skos:altLabel	"pyranosone dehydratase"
GO:0033991	skos:prefLabel	"aldos-2-ulose dehydratase"
GO:0033991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose = H2O + microthecin
RHEA:65697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine
REACT:R-GGA-389350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 by pVav1 (Gallus gallus)
RHEA:29139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + menaquinol-8 + nitrate = 2 H(+)(out) + H2O + menaquinone-8 + nitrite
REACT:R-MMU-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Mus musculus)
GO:0047895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde dismutase activity
GO:0047895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formaldehyde:formaldehyde oxidoreductase activity
GO:0047895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cannizzanase activity
GO:0047895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde dismutase activity
GO:0047895	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinoprotein aldehyde dismutase
REACT:R-XTR-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Xenopus tropicalis)
REACT:R-DME-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Drosophila melanogaster)
REACT:R-SSC-3132759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds RCbl (Sus scrofa)
RHEA:60581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Schizosaccharomyces pombe)
RHEA:17593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
RHEA:17593	skos:prefLabel	"glutamine--phenylpyruvate transaminase"
RHEA:17593	skos:altLabel	"glutamine transaminase K"
RHEA:17593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamine--phenylpyruvate transaminase"
RHEA:17593	skos:altLabel	"glutamine--phenylpyruvate aminotransferase"
GO:0031435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKKK binding
GO:0031435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitogen-activated protein kinase kinase kinase binding
RHEA:17848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH
RHEA:16008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O
RHEA:18037	skos:prefLabel	"agmatine deiminase"
RHEA:18037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"agmatine deiminase"
RHEA:18037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + H2O = N-carbamoylputrescine + NH4(+)
REACT:R-BTA-981809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Bos taurus)
REACT:R-DME-8956184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Drosophila melanogaster)
REACT:R-XTR-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Xenopus tropicalis)
REACT:R-SSC-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Sus scrofa)
REACT:R-CFA-373716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacting NCK-1 (Canis familiaris)
RHEA:19275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminate + phosphate => H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate
REACT:R-DDI-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Dictyostelium discoideum)
REACT:R-CFA-9020253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Canis familiaris)
REACT:R-CFA-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Canis familiaris)
REACT:R-HSA-9670436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS (Homo sapiens)
RHEA:71021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(in) + L-valine(out) => L-phenylalanine(out) + L-valine(in)
REACT:R-XTR-216723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Xenopus tropicalis)
RHEA:55939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-hydroxyretinol + NAD(+) <=> all-trans-4-hydroxyretinal + H(+) + NADH
REACT:R-HSA-8950575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12A:IL12B translocates from ER lumen to Golgi (Homo sapiens)
REACT:R-GGA-977239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2    (Gallus gallus)
REACT:R-SSC-2453876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTR:RBP:atROL binds to STRA6 receptor (Sus scrofa)
RHEA:56310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-977602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to MCP, CR1:C4b, C3b (Bos taurus)
RHEA:39842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA
REACT:R-DME-374922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenalin synaptic vesicle docking and priming (Drosophila melanogaster)
REACT:R-BTA-3371518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 binds to HSF1 (Bos taurus)
REACT:R-HSA-8933452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE dimer binds phosphorylated DENND1 proteins (Homo sapiens)
GO:0008823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cupric reductase activity
RHEA:57839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + thermospermine <=> 3-aminopropanal + H2O2 + spermidine
REACT:R-DRE-5686900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 recruits DCLRE1C to ATM (Danio rerio)
REACT:R-DRE-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Danio rerio)
REACT:R-DME-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
REACT:R-XTR-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Xenopus tropicalis)
RHEA:53457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)
RHEA:30690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate
RHEA:68546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-beta-farnesene + diphosphate => (2Z,6Z)-farnesyl diphosphate
RHEA:58465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP
RHEA:53743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O <=> [Rab1 protein]-L-tyrosine + AMP + H(+)
REACT:R-DME-1251997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ERBB4m80 by gamma-scretase complex (Drosophila melanogaster)
REACT:R-MMU-879201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bcl-2 and Bcl-XL bind NLRP1 (Mus musculus)
GO:0018831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-chloro-1,2,4-trihydroxybenzene dechlorinase activity
RHEA:37962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-BTA-159795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Bos taurus)
REACT:R-HSA-9013109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GEFs activate RHOC (Homo sapiens)
RHEA:52901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide => 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate
RHEA:13163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-oxobutanoate + H(+) + NADH => L-threonine + NAD(+)
RHEA:34127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranylpyrophosphate--olivetolic acid geranyltransferase"
RHEA:34127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + olivetolate = cannabigerolate + diphosphate
RHEA:34127	skos:prefLabel	"geranylpyrophosphate--olivetolic acid geranyltransferase"
RHEA:32707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (2R,4S)-bornyl diphosphate
RHEA:32707	skos:altLabel	"(-)-bornyl pyrophosphate cyclase"
RHEA:32707	skos:prefLabel	"(-)-bornyl diphosphate synthase"
RHEA:32707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-bornyl diphosphate synthase"
RHEA:32707	skos:altLabel	"bornyl pyrophosphate synthase"
RHEA:17002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amidinoproclavaminate + H2O => proclavaminate + urea
REACT:R-XTR-8874685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds MET (Xenopus tropicalis)
RHEA:34411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabigerolate + O2 = cannabidiolate + H2O2
RHEA:34411	skos:prefLabel	"cannabidiolic acid synthase"
RHEA:34411	skos:altLabel	"CBDA synthase"
RHEA:34411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cannabidiolic acid synthase"
RHEA:48065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b (d18:1(4E)) + H2O => ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate
RHEA:62413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H2O => acetyl-CoA + vanillin
REACT:R-CFA-372480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Canis familiaris)
GO:0047813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NAD(+) = D-xylulose + H(+) + NADH
GO:0047813	skos:prefLabel	"D-arabinitol 4-dehydrogenase"
GO:0047813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arabinitol 4-dehydrogenase"
GO:0047813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol 4-dehydrogenase activity
EC:3.4.24.39	skos:prefLabel	"deuterolysin"
EC:3.4.24.39	skos:altLabel	"microbial neutral proteinase II"
EC:3.4.24.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deuterolysin"
EC:3.4.24.39	skos:altLabel	"acid metalloproteinase"
EC:3.4.24.39	skos:altLabel	"Penicillium roqueforti protease II"
REACT:R-BTA-5624131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B binds myristoylated proteins (Bos taurus)
REACT:R-XTR-5638009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Xenopus tropicalis)
RHEA:64483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate
RHEA:55777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate => 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP
REACT:R-MMU-1433451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds to p-KIT (Mus musculus)
REACT:R-BTA-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)
RHEA:36642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine <=> 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine
REACT:R-HSA-1295632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA2A dephosphorylates SPRY2 (Homo sapiens)
GO:0052757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin hydrolase activity
GO:0052757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin endo-beta-galactosaminidase activity
REACT:R-CFA-202437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 (Canis familiaris)
RHEA:52667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain (3S)-3-hydroxyacyl-CoA <=> a short-chain (2E)-enoyl-CoA + H2O
REACT:R-RNO-70510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer oxidises LACT to PYR (Rattus norvegicus)
REACT:R-MMU-77613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR2 homodimer to dsRNA duplex (Mus musculus)
RHEA:27731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) => beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate
REACT:R-RNO-2250301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyrrole cross-links (Rattus norvegicus)
GO:0140800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid:proton antiporter activity
RHEA:60027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-chrysanthemyl diphosphate + H2O <=> (R,R)-chrysanthemol + diphosphate
REACT:R-MMU-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Mus musculus)
RHEA:13200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + sulfite + UDP-alpha-D-glucose <=> H2O + UDP-alpha-D-6-sulfoquinovose
RHEA:61675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-cysteine <=> diphosphate + L-cysteinyl-5'-AMP
REACT:R-DDI-8867876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Dictyostelium discoideum)
REACT:R-SSC-201639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of GAS2 (Sus scrofa)
REACT:R-SSC-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Sus scrofa)
RHEA:22317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxydocosanoate + UDP-alpha-D-glucose => 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP
RHEA:29216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + menaquinol-8 => menaquinone-8 + succinate
REACT:R-HSA-9683664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates Nucleoprotein (Homo sapiens)
REACT:R-BTA-749452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gq complex dissociates (Bos taurus)
REACT:R-MMU-372697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binding to p130cas (Mus musculus)
REACT:R-HSA-3249386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)
REACT:R-BTA-174739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant + apoE => chylomicron remnant:apoE complex (Bos taurus)
RHEA:20685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NAD(+) = H(+) + keto-D-tagatose + NADH
RHEA:20685	skos:prefLabel	"galactitol 2-dehydrogenase"
RHEA:20685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactitol 2-dehydrogenase"
GO:0061788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Epidermal Growth Factor repeat binding
GO:0061788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF repeat binding
GO:0061788	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Epidermal growth factor domain binding
REACT:R-GGA-419428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR2-5 bind S1P (Gallus gallus)
REACT:R-CEL-173709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C7 binds C5b:C6 (Caenorhabditis elegans)
REACT:R-DRE-8982163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Danio rerio)
RHEA:53531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:29307	skos:prefLabel	"methanesulfonate monooxygenase (FMNH2)"
RHEA:29307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + methanesulfonate + O2 = FMN + formaldehyde + 2 H(+) + H2O + sulfite
RHEA:29307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methanesulfonate monooxygenase (FMNH2)"
GO:0043831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulphate:quinone oxidoreductase activity
GO:0043831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulphate dehydrogenase (quinone) activity
GO:0043831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate oxidoreductase, tetrathionate-forming activity
GO:0043831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TQO
GO:0043831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DoxA
GO:0043831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate:quinone oxidoreductase activity
GO:0043831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DoxD
GO:0043831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate:6-decylubiquinone oxidoreductase activity
GO:0043831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate dehydrogenase (quinone) activity
RHEA:63667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH <=> H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)
RHEA:52995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine <=> [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine
RHEA:46910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA
RHEA:69605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic UMP + diphosphate => UTP
GO:0004468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine acetyltransferase activity
GO:0004468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine N6-acetyltransferase activity
GO:0004468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-phosphate:L-lysine N6-acetyltransferase activity
GO:0004468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAT acetylates microtubules (Homo sapiens)
GO:0004468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine N(6)-acetyltransferase activity
GO:0004468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-phosphate:L-lysine 6-N-acetyltransferase activity
GO:0004468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0004468	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LAT activity
RHEA:52057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hexadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + hexadecanoate
REACT:R-GGA-187545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cks1 with SCF(Skp2) complex (Gallus gallus)
RHEA:32397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2S,4S)-dihydrocarveol + NAD(+)
REACT:R-MMU-1169399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Mus musculus)
REACT:R-GGA-199425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLPP dephosphorylates S473 in AKT (Gallus gallus)
RHEA:43724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"farnesoate epoxidase"
RHEA:43724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]
RHEA:43724	skos:altLabel	"CYP15C1"
RHEA:43724	skos:prefLabel	"farnesoate epoxidase"
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diacylglycerol--inositol phosphatidyltransferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol synthase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-DG:inositol transferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP diglyceride-inositol phosphatidyltransferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoglyceride-inositol phosphatidyltransferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoglyceride-inositol transferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diglyceride:inositol transferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diglyceride-inositol transferase activity
GO:0003881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity
GO:0045521	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-25
GO:0045521	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-25 receptor ligand
GO:0045521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-25 receptor binding
REACT:R-HSA-177924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
REACT:R-XTR-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Xenopus tropicalis)
RHEA:10951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucosamine <=> ADP + D-glucosamine 6-phosphate + H(+)
REACT:R-SSC-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Sus scrofa)
REACT:R-CFA-8856525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANGPTL8 binds ANGPTL3 (Canis familiaris)
REACT:R-CFA-8850786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK12 (Canis familiaris)
GO:0052893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polyamine oxidase (propane-1,3-diamine-forming)"
GO:0052893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
GO:0052893	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyamine oxidase (propane-1,3-diamine-forming) activity
GO:0052893	skos:altLabel	"maize PAO"
GO:0052893	skos:altLabel	"MPAO"
GO:0052893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine + O2 = H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine
GO:0052893	skos:prefLabel	"polyamine oxidase (propane-1,3-diamine-forming)"
REACT:R-SSC-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Sus scrofa)
GO:0044390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2 protein ligase binding
GO:0044390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein conjugating enzyme binding
GO:0044390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small protein conjugating enzyme binding
REACT:R-BTA-9632918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Bos taurus)
REACT:R-DME-373750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:ErbB2 (Drosophila melanogaster)
REACT:R-GGA-1181149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Gallus gallus)
RHEA:50366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:44324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-butyrylglycerol + H2O = butanoate + glycerol + H(+)
REACT:R-HSA-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Homo sapiens)
REACT:R-RNO-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Rattus norvegicus)
RHEA:21533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione + glutathionylspermidine => ADP + H(+) + phosphate + trypanothione
REACT:R-XTR-9020261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Xenopus tropicalis)
RHEA:67312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = myceliothermophin E
REACT:R-DRE-392295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma recruits PI3K gamma (Danio rerio)
RHEA:16944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylindoxyl + O2 <=> H2O + N-acetylisatin
REACT:R-SSC-8851979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL9 binds immune cell surfaces (Sus scrofa)
REACT:R-DME-450723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and MSN activate HEP (Drosophila melanogaster)
RHEA:11751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetaldehyde + L-threonine <=> 4-fluoro-L-threonine + acetaldehyde
RHEA:60668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-chrysanthemol + NAD(+) = (1R,3R)-chrysanthemal + H(+) + NADH
REACT:R-HSA-2533965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NID1 degradation by MMP14, MMP15 (Homo sapiens)
RHEA:18969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + H(+) + hnu = a long-chain alkane + CO2
RHEA:13363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glycerol + diphosphate => CTP + H(+) + sn-glycerol 3-phosphate
REACT:R-RNO-3321883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSL acetylates histone H4 (Rattus norvegicus)
RHEA:14719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate => D-erythrose 4-phosphate + H2O + phosphoenolpyruvate
REACT:R-DRE-2267372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Danio rerio)
REACT:R-SCE-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Saccharomyces cerevisiae)
REACT:R-GGA-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Gallus gallus)
REACT:R-XTR-8848774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds DOK1 (Xenopus tropicalis)
REACT:R-DME-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Drosophila melanogaster)
REACT:R-RNO-8854303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D11 binds RAB6 (Rattus norvegicus)
REACT:R-HSA-445124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Patched binds Smoothened (Homo sapiens)
RHEA:16995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein]
EC:3.4.21.48	skos:altLabel	"proteinase yscB"
EC:3.4.21.48	skos:prefLabel	"cerevisin"
EC:3.4.21.48	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cerevisin"
EC:3.4.21.48	skos:altLabel	"yeast proteinase B"
REACT:R-BTA-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Bos taurus)
REACT:R-HSA-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
RHEA:30549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA + H2O => (3S)-hydroxyhexanoyl-CoA
REACT:R-DRE-158118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Danio rerio)
REACT:R-RNO-451366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38MAPK by DSCAM (Rattus norvegicus)
RHEA:29087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + menaquinone-8 = menaquinol-8 + oxaloacetate
REACT:R-GGA-351456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of gamma H2AX and NBS1 (Gallus gallus)
REACT:R-BTA-205112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Bos taurus)
RHEA:65524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:39289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein] => Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine
RHEA:41616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 2,5-bisphosphate + H2O = D-ribose 5-phosphate + phosphate
RHEA:31595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylureidoacrylate + H2O = (Z)-2-methylaminoacrylate + carbamate + H(+)
REACT:R-BTA-202939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of E-Cadherin (Bos taurus)
RHEA:72240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + L-glutamate(in) => estrone 3-sulfate(in) + L-glutamate(out)
REACT:R-CEL-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Caenorhabditis elegans)
REACT:R-DME-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Drosophila melanogaster)
REACT:R-HSA-109860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 phosphorylates MAPK3 (Homo sapiens)
REACT:R-CFA-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RHEA:22309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + xylitol => D-xylose + H2O2
RHEA:34662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + S-adenosyl-L-methionine <=> 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Sus scrofa)
REACT:R-RNO-8849082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 stimulates RHOA GTPase activity (Rattus norvegicus)
REACT:R-BTA-2730959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN7:OSTM1 exchanges Cl- for H+ (Bos taurus)
REACT:R-MMU-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Mus musculus)
RHEA:14852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-amidino-L-aspartate <=> L-aspartate + urea
RHEA:11413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymethyl-7,8-dihydropterin + ATP => (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)
RHEA:55791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + H(+) + NADH + O2 <=> H2O + hydroxyacetone + NAD(+)
RHEA:65543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + H2O <=> an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose
RHEA:14859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate => (indol-3-yl)acetate + ATP + L-lysine
REACT:R-DRE-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-lactamase I-III
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ampicillinase activity
GO:0008800	skos:altLabel	"penicillinase"
GO:0008800	skos:prefLabel	"beta-lactamase"
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exopenicillinase activity
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penicillin amido-beta-lactamhydrolase activity
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-lactamase activity
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-lactamase"
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penicillinase I, II
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neutrapen
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-lactam + H2O = a substituted beta-amino acid
GO:0008800	skos:altLabel	"cephalosporinase"
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penicillin beta-lactamase activity
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-lactamase AME I
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-lactamase A, B, C
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-lactam hydrolase activity
GO:0008800	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin-beta-lactamase activity
RHEA:44660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)
RHEA:14827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carvone + H(+) + NADH => (1R,5S)-carveol + NAD(+)
RHEA:22328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate
GO:0102514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity
RHEA:42275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA
RHEA:19874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate + H2O => 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate
RHEA:71298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) <=> chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)
REACT:R-RNO-202917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 1 (Rattus norvegicus)
REACT:R-HSA-9703436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants (Homo sapiens)
RHEA:31155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADH
REACT:R-CFA-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Canis familiaris)
REACT:R-DRE-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Danio rerio)
REACT:R-CEL-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Caenorhabditis elegans)
REACT:R-MMU-2485148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Mus musculus)
RHEA:46341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-hexadecanoylsphing-4-enine => ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate
REACT:R-GGA-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
REACT:R-MMU-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Mus musculus)
RHEA:40444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + ATP => 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)
REACT:R-RNO-446870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated TRAF6 binds the TAK1 complex (Rattus norvegicus)
RHEA:68713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (1S,2S,4R)-beta-elemene + diphosphate
REACT:R-RNO-373705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of DCC (Rattus norvegicus)
RHEA:51240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-DDI-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Dictyostelium discoideum)
RHEA:11484	skos:prefLabel	"quinol--cytochrome-c reductase"
RHEA:11484	skos:altLabel	"complex III (mitochondrial electron transport)"
RHEA:11484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
RHEA:11484	skos:altLabel	"ubiquinol--cytochrome-c reductase"
RHEA:11484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinol--cytochrome-c reductase"
RHEA:11484	skos:altLabel	"ubiquinone--cytochrome-c oxidoreductase"
RHEA:11484	skos:altLabel	"cytochrome bc1 complex"
RHEA:48920	skos:prefLabel	"3,8-divinyl chlorophyllide a reductase"
RHEA:48920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,8-divinyl chlorophyllide a reductase"
RHEA:48920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
EC:1.6.4.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a disulfide as acceptor"
EC:1.6.4.-	skos:prefLabel	"With a disulfide as acceptor"
REACT:R-SCE-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Saccharomyces cerevisiae)
RHEA:53777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanylpropanoate + O2 => 3-sulfinopropanoate + H(+)
REACT:R-DRE-5696997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP24 deubiquitinates DDB2 (Danio rerio)
REACT:R-MMU-2002428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen N-propeptides (Mus musculus)
REACT:R-SSC-5685838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex binds D-loop structures (Sus scrofa)
GO:0102577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-palmitate decarboxylase activity
REACT:R-BTA-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Bos taurus)
REACT:R-BTA-8848873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates ARAP1 (Bos taurus)
GO:0033134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin activating enzyme binding
REACT:R-SSC-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Sus scrofa)
REACT:R-MMU-8869667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxLDL:CD36 binds TLR4:TLR6 (Mus musculus)
RHEA:61622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-mannosyl](n+1) + GDP + H(+) => [(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose
REACT:R-CFA-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Canis familiaris)
GO:0015280	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	amiloride-sensitive sodium channel activity
GO:0015280	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acid-sensing ion channel activity
GO:0015280	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ASIC activity
GO:0015280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNN channels transport extracellular Na+ to cytosol (Homo sapiens)
GO:0015280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-gated sodium channel activity
GO:0015280	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	epithelial sodium channel
REACT:R-HSA-2396606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)
RHEA:49357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-388605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMC(138-176) binds MC2R (Canis familiaris)
REACT:R-CFA-5687465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds RBBP8 (Canis familiaris)
REACT:R-HSA-9685281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome (Homo sapiens)
RHEA:36214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate
RHEA:27484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:49908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)
RHEA:59274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cysteine => L-cysteine
REACT:R-BTA-6787321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DERA cleaves dR5P to GA3P and CH3CHO (Bos taurus)
GO:0050545	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)
GO:0050545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphopyruvate decarboxylase activity
GO:0050545	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfopyruvate carboxy-lyase activity
GO:0050545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfopyruvate decarboxylase activity
RHEA:30462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol <=> (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone
RHEA:68017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl phosphate + H2O => (2E,6E,10E)-geranylgeraniol + phosphate
RHEA:16744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA
RHEA:57553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Rattus norvegicus)
REACT:R-DME-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Drosophila melanogaster)
REACT:R-MMU-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Mus musculus)
REACT:R-GGA-6803789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Gallus gallus)
RHEA:66491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quillate + UDP-alpha-D-glucose <=> quillaic acid 28-beta-D-glucoside + UDP
REACT:R-HSA-917888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF binds 2Fe3+ to form holoTF (Homo sapiens)
REACT:R-DRE-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Danio rerio)
REACT:R-CEL-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
REACT:R-CEL-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Caenorhabditis elegans)
REACT:R-XTR-8952903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRHL2 hydrolyses poly(ADP-ribose) (Xenopus tropicalis)
REACT:R-XTR-76472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ethylene is oxidized to Ethylene oxide by CYP1A1 (Xenopus tropicalis)
RHEA:42579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O <=> 2-methylpropanoate + 2-oxopent-4-enoate + H(+)
RHEA:12885	skos:prefLabel	"tRNA-queuosine alpha-mannosyltransferase"
RHEA:12885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-queuosine alpha-mannosyltransferase"
RHEA:12885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) = GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)
RHEA:72634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + 3 Li(+)(out) <=> Ca(2+)(out) + 3 Li(+)(in)
REACT:R-SSC-8964284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in active Gq-BTK complex is activated (Sus scrofa)
REACT:R-CEL-390909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds hist (Caenorhabditis elegans)
RHEA:11381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate
RHEA:28445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP] <=> dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]
RHEA:62251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetaldehyde + H2O + NADP(+) <=> chloroacetate + 2 H(+) + NADPH
REACT:R-SPO-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Schizosaccharomyces pombe)
RHEA:53446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone
RHEA:64094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2
RHEA:45253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetradecanoate(out) => tetradecanoate(in)
REACT:R-CEL-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Caenorhabditis elegans)
REACT:R-MMU-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)
REACT:R-RNO-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)
REACT:R-MMU-9038161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Mus musculus)
RHEA:38703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:42785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine
REACT:R-BTA-110364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Bos taurus)
REACT:R-DRE-8863101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPPL2a/b cleaves TNF(1-76) (Danio rerio)
RHEA:59102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + triglucosyl-enterobactin + UDP => diglucosyl-enterobactin + UDP-alpha-D-glucose
REACT:R-XTR-8848713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds BCAR1 (Xenopus tropicalis)
RHEA:14772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nicotine + A + H2O <=> (S)-6-hydroxynicotine + AH2
REACT:R-DME-426522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nonendonucleolytic RISC binds exactly matching target RNAs (Drosophila melanogaster)
RHEA:35625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-D-glutamyl-D-glutamate + NH4(+) => D-glutamate + D-glutamine
RHEA:13088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O <=> CoA + L-2-acetamido-6-oxoheptanedioate
REACT:R-HSA-75080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC A complex (Homo sapiens)
REACT:R-HSA-9698333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike trimer moves into the ERGIC membrane (Homo sapiens)
RHEA:42157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)
REACT:R-CFA-70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Canis familiaris)
RHEA:33430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl alpha-D-glucosaminide + L-cysteine <=> bacillithiol + H2O
REACT:R-XTR-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Xenopus tropicalis)
REACT:R-HSA-9756494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP acetylates SARS-CoV-2 N at K375 (Homo sapiens)
RHEA:44917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (3E)-decenoyl-CoA + NADP(+)
RHEA:15984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-methionine <=> CO2 + S-adenosyl 3-(methylsulfanyl)propylamine
REACT:R-CEL-158860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates NHABP (Caenorhabditis elegans)
REACT:R-MMU-1592349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14 (MT1-MMP) binds TIMP2 (Mus musculus)
RHEA:69162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+) => agmatine + H2O + O2
REACT:R-GGA-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)
REACT:R-HSA-2328129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dystroglycan binds Laminins and Dystrophin (Homo sapiens)
REACT:R-DRE-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Danio rerio)
REACT:R-XTR-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Xenopus tropicalis)
REACT:R-HSA-9653745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translation of ATF5 (Homo sapiens)
REACT:R-RNO-5334794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABPs bind LCFAs (Rattus norvegicus)
REACT:R-HSA-5223313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Homo sapiens)
REACT:R-SCE-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Saccharomyces cerevisiae)
RHEA:41346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2
REACT:R-CFA-9014641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Canis familiaris)
REACT:R-HSA-8942224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
RHEA:17702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + geranoyl-CoA + hydrogencarbonate => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate
REACT:R-DME-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Drosophila melanogaster)
REACT:R-GGA-8949659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Gallus gallus)
RHEA:24235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH
REACT:R-CEL-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
REACT:R-CFA-1250357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds P-ERBB4 isoform dimers (Canis familiaris)
REACT:R-DME-6805276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates TP53 (Drosophila melanogaster)
REACT:R-MMU-1462003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNP1-4 are stored in primary neutrophil granules (Mus musculus)
RHEA:49234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate(in) + L-histidyl-[protein] => D-mannose(out) + N(pros)-phospho-L-histidyl-[protein]
REACT:R-RNO-5358343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT palmitoylates Hh N-terminal fragment (Rattus norvegicus)
RHEA:54858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl hexanoate + H2O + NADP(+) => H(+) + NADPH + O2 + octan-3-one
REACT:R-XTR-109514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Xenopus tropicalis)
RHEA:27514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphinganine 1-phosphate = phosphate + sphinganine
REACT:R-SSC-74207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Sus scrofa)
RHEA:68202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoyl-3-hexadecanoylglycerol + CoA => 1,2-dihexanoylglycerol + hexadecanoyl-CoA
REACT:R-CFA-191654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-src associates with Cx43 in gap junctions (Canis familiaris)
REACT:R-RNO-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Rattus norvegicus)
REACT:R-CFA-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Canis familiaris)
REACT:R-XTR-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Xenopus tropicalis)
REACT:R-MMU-9014456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOG (Mus musculus)
RHEA:24169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-CFA-9620456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sGC stimulators bind sGC:NO (Canis familiaris)
REACT:R-DRE-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Danio rerio)
RHEA:62193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + peregrinol + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Dictyostelium discoideum)
REACT:R-HSA-265645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Influx through Voltage-gated Calcium Channels (Homo sapiens)
REACT:R-BTA-158832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT2 (Bos taurus)
REACT:R-DME-9758604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
RHEA:10884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fucosterol-epoxide lyase"
RHEA:10884	skos:altLabel	"(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase"
RHEA:10884	skos:prefLabel	"fucosterol-epoxide lyase"
RHEA:10884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,24(1)R)-fucosterol epoxide = acetaldehyde + desmosterol
RHEA:42561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(27/28) in mitochondrial tRNA => pseudouridine(27/28) in mitochondrial tRNA
REACT:R-HSA-389481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)
REACT:R-DRE-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Danio rerio)
RHEA:46866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli)
RHEA:22643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sphinganine <=> 3-oxosphinganine + H(+) + NADPH
RHEA:62421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (R)-2-hydroxy fatty acid + O2 => a fatty acid + CO2 + H2O
RHEA:28844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline(in) + H(+)(in) => choline(out) + H(+)(out)
REACT:R-MMU-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Mus musculus)
RHEA:62765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-XTR-9724670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds imiquimod (Xenopus tropicalis)
RHEA:40566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)
REACT:R-BTA-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)
REACT:R-CFA-183055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to EGFR (Canis familiaris)
REACT:R-RNO-74059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)
REACT:R-GGA-114670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binds to vWF:Collagen complex (Gallus gallus)
RHEA:35585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-gluconate
REACT:R-SSC-83788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to Type 2 promoter (Sus scrofa)
REACT:R-HSA-8953917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)
REACT:R-RNO-201486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand pleiotrophin (PTN) (Rattus norvegicus)
REACT:R-SSC-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Sus scrofa)
REACT:R-DME-450499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B (AKT) phosphorylates KSRP (Drosophila melanogaster)
REACT:R-SSC-5656070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFBPs bind FGFs (Sus scrofa)
RHEA:12702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate
REACT:R-SSC-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Sus scrofa)
REACT:R-CEL-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)
RHEA:12675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nitrile + H2O => an aliphatic amide
RHEA:66709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate
REACT:R-DRE-5682690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 dissociates from ATG12:ATG5 (Danio rerio)
REACT:R-CFA-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Canis familiaris)
REACT:R-HSA-934604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SPRY2 is ubiquitinated by CBL (Homo sapiens)
EC:1.14.14.129	skos:prefLabel	"long-chain acyl-CoA omega-monooxygenase"
EC:1.14.14.129	skos:altLabel	"CYP86A22"
EC:1.14.14.129	skos:altLabel	"CYP52M1"
EC:1.14.14.129	skos:altLabel	"long-chain acyl-CoA omega-hydroxylase"
EC:1.14.14.129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain acyl-CoA omega-monooxygenase"
RHEA:70909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate
RHEA:23764	skos:altLabel	"pyrophosphate--serine phosphotransferase"
RHEA:23764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diphosphate--serine phosphotransferase"
RHEA:23764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-serine = H(+) + O-phospho-L-serine + phosphate
RHEA:23764	skos:prefLabel	"diphosphate--serine phosphotransferase"
REACT:R-MMU-879584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO3A1 isoform 1 has abroad substrate specificity (Mus musculus)
REACT:R-RNO-210292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and TREM1 (Rattus norvegicus)
REACT:R-MMU-192056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Mus musculus)
REACT:R-MMU-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Mus musculus)
REACT:R-DRE-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Danio rerio)
REACT:R-XTR-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Xenopus tropicalis)
REACT:R-DRE-9027628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises EPA to 5-HEPE (Danio rerio)
REACT:R-DRE-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Danio rerio)
GO:0047906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity
GO:0047906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)
GO:0047906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucosterol-epoxide lyase activity
REACT:R-HSA-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Homo sapiens)
REACT:R-DDI-9706390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds interacting proteins at trans-Golgi network (Dictyostelium discoideum)
GO:0140840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain P6 isomerase activity
REACT:R-SSC-4086216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII binds integrin alpha2beta1 (Sus scrofa)
REACT:R-RNO-5693566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 associates with H4K20Me2 at DNA DSBs (Rattus norvegicus)
REACT:R-BTA-2130500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of MHC II:Ii complex in to the plasma membrane (Bos taurus)
REACT:R-HSA-2220971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK8 phosphorylates NICD1 PEST domain mutants  (Homo sapiens)
REACT:R-DME-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Drosophila melanogaster)
RHEA:32660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + 2 NADP(+) => (6E)-8-oxogeranial + 2 H(+) + 2 NADPH
REACT:R-BTA-451561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO binds polyubiquitinated IRAK1 (Bos taurus)
RHEA:50740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene C4 = glycine + leukotriene F4
REACT:R-RNO-5624949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the anterograde IFT train (Rattus norvegicus)
RHEA:58949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
RHEA:18643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol => a menaquinone + H2
REACT:R-HSA-9622668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO3,(FOXO1) bind BBC3 gene first intron (Homo sapiens)
REACT:R-DRE-187688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Danio rerio)
RHEA:33713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + maleylacetate + sulfite => 4-sulfomuconolactone + H2O
REACT:R-CEL-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Caenorhabditis elegans)
RHEA:70079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + clavatol + O2 = CO2 + hydroxyclavatol + succinate
RHEA:40292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + tetradecanedioate => AMP + diphosphate + tetradecanedioyl-CoA
REACT:R-CEL-375160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 binds to ATP (Caenorhabditis elegans)
RHEA:62217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoepoxydon + NADP(+) => H(+) + NADPH + phyllostine
REACT:R-HSA-193763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)
REACT:R-BTA-373358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR6 binds CXCL16 ligand (Bos taurus)
REACT:R-RNO-1671687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR activation (Rattus norvegicus)
RHEA:20827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + ATP <=> ADP + AMP + H(+)
RHEA:18948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]
REACT:R-RNO-904864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Rattus norvegicus)
REACT:R-PFA-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Plasmodium falciparum)
REACT:R-SSC-3132737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate ETS1 and ETS2 (Sus scrofa)
REACT:R-MMU-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Mus musculus)
RHEA:13624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose <=> 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose
REACT:R-BTA-202704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaXbeta2 binds JAM3 (Bos taurus)
RHEA:52642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA
REACT:R-BTA-5696670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD1L is recruited to GG-NER site (Bos taurus)
GO:0097023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 6-phosphate aldolase activity
GO:0097023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone
RHEA:10175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoate dimer + H2O <=> 2 (R)-3-hydroxybutanoate + H(+)
REACT:R-HSA-5617408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R binds the GLI1 promoter (Homo sapiens)
REACT:R-BTA-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Bos taurus)
RHEA:52330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin] => L-arginine + O2 + reduced [flavodoxin]
RHEA:53165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)
REACT:R-RNO-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Rattus norvegicus)
REACT:R-XTR-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Xenopus tropicalis)
REACT:R-HSA-6799441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)
REACT:R-DRE-8854897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Danio rerio)
REACT:R-SCE-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Saccharomyces cerevisiae)
RHEA:54756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deamido-NAD(+) + hydrogencarbonate = AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide
RHEA:54756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridinium-3,5-biscarboxylic acid mononucleotide synthase"
RHEA:54756	skos:altLabel	"nicotinic acid adenine dinucleotide carboxylase/hydrolase"
RHEA:54756	skos:altLabel	"P2CMN synthase"
RHEA:54756	skos:prefLabel	"pyridinium-3,5-biscarboxylic acid mononucleotide synthase"
RHEA:54756	skos:altLabel	"NaAD carboxylase/hydrolase"
REACT:R-DRE-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Danio rerio)
RHEA:46574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DDI-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)
REACT:R-HSA-9626034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF1A1 dissociates from p-GFAP (Homo sapiens)
REACT:R-BTA-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Bos taurus)
REACT:R-SSC-202459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Bcl10 (Sus scrofa)
REACT:R-HSA-5625717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PKN1 binds androgen receptor (AR) (Homo sapiens)
REACT:R-SSC-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Sus scrofa)
REACT:R-HSA-1602417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Homo sapiens)
RHEA:38138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-RNO-391935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP1 receptor can bind PGD2 (Rattus norvegicus)
RHEA:58156	skos:altLabel	"sodium-transporting two-sector ATPase"
RHEA:58156	skos:altLabel	"ATP synthase, sodium ion specific"
RHEA:58156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + 4 Na(+)(in) = ADP + H(+) + 4 Na(+)(out) + phosphate
RHEA:58156	skos:prefLabel	"Na(+)-transporting two-sector ATPase"
RHEA:58156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Na(+)-transporting two-sector ATPase"
RHEA:58156	skos:altLabel	"Na(+)-translocating ATPase"
RHEA:26290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine => 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate
REACT:R-SPO-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Schizosaccharomyces pombe)
RHEA:18555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyfumarate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)
RHEA:36622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydocosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine
REACT:R-CEL-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Caenorhabditis elegans)
REACT:R-DRE-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Danio rerio)
REACT:R-DME-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Drosophila melanogaster)
REACT:R-MMU-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Mus musculus)
RHEA:66908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine = 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A
RHEA:19729	skos:prefLabel	"acetoacetate decarboxylase"
RHEA:19729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + H(+) = acetone + CO2
RHEA:19729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetoacetate decarboxylase"
RHEA:19729	skos:altLabel	"acetoacetate carboxy-lyase"
REACT:R-CFA-6803545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)
REACT:R-CFA-202721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 binds JAM3 (Canis familiaris)
RHEA:45503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]
REACT:R-RNO-2870221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-selectin binds E-selectin ligand (Rattus norvegicus)
REACT:R-SCE-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)
GO:0030340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyaluronate lyase activity
GO:0030340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spreading factor activity
GO:0030340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hyaluronidase [but cf. EC:3.2.1.35 (hyalurononglucosaminidase) and EC:3.2.1.36 (hyaluronoglucuronidase)]
GO:0030340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronoglycosaminoglycan lyase activity
GO:0030340	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hyaluronidase activity
GO:0030340	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mucinase activity
RHEA:11857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
REACT:R-CEL-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Caenorhabditis elegans)
REACT:R-SSC-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
REACT:R-GGA-5625959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Gallus gallus)
REACT:R-SSC-8855508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Sus scrofa)
REACT:R-RNO-8986985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Rattus norvegicus)
RHEA:37618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
RHEA:20210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + xylitol => ADP + H(+) + xylitol 5-phosphate
REACT:R-SSC-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Sus scrofa)
GO:0080049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulono-1,4-lactone dehydrogenase activity
REACT:R-RNO-549304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal clearance of organic cations (Rattus norvegicus)
REACT:R-HSA-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Homo sapiens)
REACT:R-HSA-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Homo sapiens)
RHEA:33524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O => acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)
REACT:R-CFA-1236941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of receptor bound antigen into clathrin coted vesicles (Canis familiaris)
REACT:R-CFA-200410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Canis familiaris)
REACT:R-BTA-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Bos taurus)
REACT:R-DRE-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Danio rerio)
RHEA:71988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene C
RHEA:63500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + S-nitrosoglutathione = NADP(+) + sulfinamide glutathione
REACT:R-CEL-6799495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYCTK phosphorylates DGA to 3PDGA (Caenorhabditis elegans)
RHEA:37831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exocellobiohydrolase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exoglucanase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-cellobiohydrolase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiohydrolase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-glucan cellobiosylhydrolase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiohydrolase I
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-D-glucan cellobiohydrolase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C1 cellulase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiosidase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-glucan cellobiohydrolase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-1,4-glucan cellobiohydrolase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	avicelase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-beta-glucan cellobiosidase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-cellobiohydrolase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CBH 1
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,4-beta-D-glucanase activity
GO:0016162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellulose 1,4-beta-cellobiosidase activity
REACT:R-MMU-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Mus musculus)
REACT:R-HSA-914182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
RHEA:71600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + maleate(in) => 2-oxoglutarate(in) + maleate(out)
RHEA:39054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholesterol(in) + H2O <=> ADP + cholesterol(out) + H(+) + phosphate
RHEA:60798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + gibberellin A20 + 2 H2O + 2 succinate => 2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2
REACT:R-SSC-9710254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME oligomerizes (Sus scrofa)
REACT:R-HSA-6791235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds AURKA (Homo sapiens)
RHEA:31816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-(E)-beta-caryophyllene + diphosphate
REACT:R-XTR-9014627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDS dimers:PXLP dehydrate L-Thr to 2AA (Xenopus tropicalis)
REACT:R-BTA-1614336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Bos taurus)
REACT:R-DRE-5696947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP47 deubiquitinates POLB (Danio rerio)
RHEA:45606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate + H(+) => D-glucaro-1,4-lactone
RHEA:66402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycocholate(in) + H2O
RHEA:10979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + quinolin-2-ol <=> 5,6-dihydroquinoline-2,5,6-triol + NAD(+)
REACT:R-CFA-9603987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Canis familiaris)
REACT:R-RNO-453183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y348-SYK dissociates (Rattus norvegicus)
REACT:R-CFA-873922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 by JAK kinases (Canis familiaris)
REACT:R-GGA-419255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate (Gallus gallus)
REACT:R-HSA-8847544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering (Homo sapiens)
REACT:R-DME-1971482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Drosophila melanogaster)
GO:0047127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiomorpholine-carboxylate dehydrogenase activity
GO:0047127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketimine reductase activity
GO:0047127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketimine-reducing enzyme
GO:0047127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity
RHEA:55637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate
RHEA:13774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine <=> 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine
REACT:R-DRE-5610763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Danio rerio)
RHEA:54835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:61926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate => (2S,4R)-ketoconazole(in) + ATP + H2O
REACT:R-RNO-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Rattus norvegicus)
RHEA:39805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+)
RHEA:14094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-tryptophan => indole-3-pyruvate + L-glutamate
RHEA:21846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(2)-phenylacetyl-L-glutamine => L-glutamine + phenylacetyl-CoA
GO:0018616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trihydroxytoluene dioxygenase activity
RHEA:68856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate
RHEA:47997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)
REACT:R-HSA-417825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y11 receptor can bind to ATP (Homo sapiens)
REACT:R-HSA-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Homo sapiens)
RHEA:30323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:69120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
GO:0036221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine triphosphate pyrophosphohydrolase activity
GO:0036221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP diphosphatase activity
REACT:R-RNO-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Rattus norvegicus)
REACT:R-DDI-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Dictyostelium discoideum)
RHEA:23395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(n-1) H2O + RNA(n) <=> n a ribonucleoside 5'-phosphate + n H(+)
RHEA:42299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]
REACT:R-DRE-5654596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)
REACT:R-XTR-173723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C8 binds C5b:C6:C7 (Xenopus tropicalis)
RHEA:38073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA
REACT:R-HSA-9674808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
REACT:R-CEL-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Caenorhabditis elegans)
REACT:R-DRE-76397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Danio rerio)
RHEA:26324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	resorcinol + S-adenosyl-L-methionine <=> 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine
RHEA:13387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-undecanone + CO2 => 3-oxododecanoate + H(+)
RHEA:24842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine
REACT:R-MMU-3928656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves EPHB2 (Mus musculus)
RHEA:58192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin = dihydrobisanhydrobacterioruberin + diphosphate
REACT:R-SSC-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Sus scrofa)
REACT:R-CEL-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Caenorhabditis elegans)
REACT:R-DME-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Drosophila melanogaster)
REACT:R-XTR-8851494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase7 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)
REACT:R-HSA-6782890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)
REACT:R-BTA-5686578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates ABL1 (Bos taurus)
REACT:R-HSA-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Homo sapiens)
REACT:R-HSA-8942101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
REACT:R-CFA-210291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Canis familiaris)
REACT:R-MMU-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Mus musculus)
RHEA:31872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => alpha-seco-amyrin
RHEA:35104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fusidate(in) => fusidate(out)
RHEA:55634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP
REACT:R-DME-1358797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated RNF41 binds P-USP8 (Drosophila melanogaster)
REACT:R-BTA-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Bos taurus)
REACT:R-CFA-9686521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2:CCNA phosphorylates TERF2 (Canis familiaris)
REACT:R-SSC-975629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11 reduces RBP2:atRAL to RBP2:atROL (Sus scrofa)
REACT:R-MMU-2022399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Mus musculus)
RHEA:67292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one
REACT:R-HSA-8863101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPPL2a/b cleaves TNF(1-76) (Homo sapiens)
RHEA:48713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(2+) + 2 H(+) + H2O2 => 2 Fe(3+) + 2 H2O
RHEA:18405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate
RHEA:18405	skos:prefLabel	"alanine dehydrogenase"
RHEA:18405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alanine dehydrogenase"
RHEA:40754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate
RHEA:51521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + S-adenosyl-L-methionine => (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-8956099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Sus scrofa)
RHEA:38801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:49528	skos:altLabel	"PET hydrolase"
RHEA:49528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)
RHEA:49528	skos:altLabel	"PETase"
RHEA:49528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"poly(ethylene terephthalate) hydrolase"
RHEA:49528	skos:prefLabel	"poly(ethylene terephthalate) hydrolase"
RHEA:41171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O = 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)
RHEA:45889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA
RHEA:37232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alaninamide => L-alanine + NH4(+)
RHEA:63743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + H(+) + NADH <=> 2-phenylethanol + NAD(+)
RHEA:45890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA
REACT:R-DRE-202534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of NEMO by TRAF6 (Danio rerio)
RHEA:50972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
RHEA:49945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate
RHEA:11398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyldeoxycytidine diphosphate + ADP => 5-methyldeoxycytidine 5'-phosphate + ATP
RHEA:63366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2
RHEA:19674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trihydroxybenzene + O2 => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)
RHEA:42414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + ATP + H(+)
RHEA:50309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5651739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Bos taurus)
REACT:R-GGA-6799977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 hydrolyzes bacterial peptidoglycan (Gallus gallus)
REACT:R-SSC-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Sus scrofa)
RHEA:51229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate => 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SSC-5694109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer hydrolyses TAG to DAG and FA (Sus scrofa)
GO:0008510	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium:bicarbonate cotransporter activity
GO:0008510	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium/bicarbonate cotransporter activity
GO:0008510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:bicarbonate symporter activity
RHEA:36607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginine + O2 = (2S,3S)-hydroxyarginine + CO2 + succinate
RHEA:36607	skos:prefLabel	"L-arginine hydroxylase"
RHEA:36607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arginine hydroxylase"
RHEA:45618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine => H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-139905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAD protein to mitochondria (Canis familiaris)
REACT:R-SSC-2395257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-hydroxylysino-norleucine cross-links (Sus scrofa)
REACT:R-GGA-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Gallus gallus)
REACT:R-SSC-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Sus scrofa)
REACT:R-XTR-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Xenopus tropicalis)
RHEA:51972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-162363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)
RHEA:33667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)
REACT:R-CFA-2090043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(7) (Canis familiaris)
REACT:R-DRE-9026405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Danio rerio)
REACT:R-BTA-448421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 translocates from the ER lumen to the extracellular region (Bos taurus)
REACT:R-BTA-1253343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds ERBB4s80 (Bos taurus)
RHEA:69354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiosulfinate => 2 (E)-prop-1-en-1-SO-peroxol
GO:0052595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aliphatic amine oxidase activity
GO:0052595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aliphatic-amine oxidase activity
GO:0052595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aliphatic-amine:oxygen oxidoreductase(deaminating) activity
REACT:R-BTA-109278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Bos taurus)
REACT:R-DME-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Drosophila melanogaster)
REACT:R-BTA-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)
RHEA:25803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + spermidine
REACT:R-CFA-432688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Canis familiaris)
RHEA:35181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone => 6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA
REACT:R-GGA-5654637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)
RHEA:30611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-zeta-carotene = AH2 + all-trans-neurosporene
RHEA:38176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + hexadecanoyl-CoA => all-trans-retinyl hexadecanoate + CoA
REACT:R-RNO-372505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylcholine synaptic vesicle docking and priming (Rattus norvegicus)
GO:0015164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronoside transmembrane transporter activity
GO:0015164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronide transporter activity
REACT:R-HSA-6791221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)
RHEA:40745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside C-K + 2 D-glucose => (20S)-ginsenoside Rd + 2 H2O
REACT:R-GGA-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Gallus gallus)
REACT:R-GGA-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Gallus gallus)
REACT:R-MMU-8985914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Mus musculus)
REACT:R-SSC-374207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled estrogen receptor 1 binds estrogen non-classically (Sus scrofa)
GO:0004847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urease (ATP-hydrolysing)
GO:0004847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urea carboxylase (hydrolyzing) activity
GO:0004847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UCA activity
GO:0004847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urea carboxylase (hydrolysing)
GO:0004847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea carboxylase activity
GO:0004847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urea:carbon-dioxide ligase (ADP-forming)
GO:0004847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UALase activity
GO:0004847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urea amidolyase activity
GO:0004847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urease (ATP-hydrolyzing) activity
GO:0004847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP--urea amidolyase activity
REACT:R-HSA-6814096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds SCOC (Homo sapiens)
REACT:R-CEL-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Caenorhabditis elegans)
RHEA:22193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
REACT:R-HSA-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Homo sapiens)
REACT:R-DRE-2509816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT16 hydrolyses IDP to IMP (Danio rerio)
RHEA:14160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + triphosphate <=> diphosphate + phosphate
RHEA:31261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-butynoate + 2 H(+) + NADH => but-3-ynal + H2O + NAD(+)
EC:3.1.30.2	skos:prefLabel	"Serratia marcescens nuclease"
EC:3.1.30.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Serratia marcescens nuclease"
EC:3.1.30.2	skos:altLabel	"endonuclease (Serratia marcescens)"
GO:0102516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity
REACT:R-HSA-9604387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4S-NICD4 binds YWHAZ (Homo sapiens)
REACT:R-SPO-6805640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates KAT6A (Schizosaccharomyces pombe)
REACT:R-CEL-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-MMU-5696490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:CLCF1 binds CNTRF (Mus musculus)
REACT:R-HSA-804969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B1 hydrogenates E1 to EST17b (Homo sapiens)
RHEA:24592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethanolamine-phosphate cytidylyltransferase"
RHEA:24592	skos:altLabel	"phosphorylethanolamine transferase"
RHEA:24592	skos:prefLabel	"ethanolamine-phosphate cytidylyltransferase"
RHEA:24592	skos:altLabel	"CTP:phosphoethanolamine cytidylyltransferase"
RHEA:24592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + phosphoethanolamine = CDP-ethanolamine + diphosphate
RHEA:13273	skos:prefLabel	"triglucosylalkylacylglycerol sulfotransferase"
RHEA:13273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"triglucosylalkylacylglycerol sulfotransferase"
RHEA:13273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol = 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)
REACT:R-XTR-5654614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)
RHEA:31530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-hydroxy-L-arginine <=> (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O
RHEA:36926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA
GO:0000031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosylphosphate transferase activity
REACT:R-SSC-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Sus scrofa)
RHEA:33544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosteryl palmitate + H2O => ergosterol + H(+) + hexadecanoate
REACT:R-SSC-177941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:GAB1 binds to phosphorylated EGFR (Sus scrofa)
REACT:R-DRE-420980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Danio rerio)
REACT:R-MMU-5218820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src kinases phosphorylate VAV (Mus musculus)
REACT:R-HSA-9623023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRP gene expression is stimulated by FOXO1 (Homo sapiens)
RHEA:56695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate
REACT:R-BTA-1614654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Bos taurus)
RHEA:18283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + H(+) + NADH => NAD(+) + succinate
REACT:R-DME-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Drosophila melanogaster)
REACT:R-GGA-2426450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins:Nidogens binds collagen type IV networks (Gallus gallus)
RHEA:58946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH
REACT:R-HSA-199583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR2DS2 interacting with HLA-C group 1 (Cw3) (Homo sapiens)
RHEA:55347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol <=> 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA
RHEA:68023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl phosphate + H2O <=> (2E)-geraniol + phosphate
REACT:R-SSC-2684507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2, 4, (3) bind FGF2 (Sus scrofa)
GO:0050289	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spermidine:(acceptor) oxidoreductase activity
GO:0050289	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spermidine:acceptor oxidoreductase activity
GO:0050289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine dehydrogenase activity
REACT:R-PFA-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Plasmodium falciparum)
REACT:R-HSA-5389841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTFMT formylates methionyl-tRNA (Homo sapiens)
REACT:R-GGA-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Gallus gallus)
RHEA:22324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leukotriene-A4 hydrolase"
RHEA:22324	skos:altLabel	"leukotriene A4 hydrolase"
RHEA:22324	skos:prefLabel	"leukotriene-A4 hydrolase"
RHEA:22324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene A4 = leukotriene B4
RHEA:22324	skos:altLabel	"LTA-4 hydrolase"
RHEA:39055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-2162019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to EXA4 by ALOX15 (Canis familiaris)
REACT:R-PFA-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Plasmodium falciparum)
REACT:R-SSC-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Sus scrofa)
REACT:R-DRE-110141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Danio rerio)
REACT:R-PFA-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Plasmodium falciparum)
RHEA:50534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein]
REACT:R-DME-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Drosophila melanogaster)
REACT:R-CFA-75238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL binds TRAIL receptors (Canis familiaris)
RHEA:36007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:66801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-9708533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 translocates from the cytosol to the nucleoplasm (Gallus gallus)
RHEA:30827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
GO:0030408	skos:altLabel	"glycine formiminotransferase"
GO:0030408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FIG formiminotransferase activity
GO:0030408	skos:altLabel	"FIG formiminotransferase"
GO:0030408	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	formimidoyltransferase activity
GO:0030408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity
GO:0030408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine
GO:0030408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formiminoglycine formiminotransferase activity
GO:0030408	skos:altLabel	"formiminoglycine formiminotransferase"
GO:0030408	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	formiminotransferase activity
GO:0030408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine formimidoyltransferase"
GO:0030408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine formiminotransferase activity
GO:0030408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine formimidoyltransferase activity
GO:0030408	skos:prefLabel	"glycine formimidoyltransferase"
REACT:R-RNO-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Rattus norvegicus)
RHEA:65081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] => asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-8948063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Drosophila melanogaster)
REACT:R-SCE-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Saccharomyces cerevisiae)
GO:0016300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (uridine) methyltransferase activity
GO:0016300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (uracil) methyltransferase activity
REACT:R-HSA-8950567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Plasminogen activator inhibitor 2 (Homo sapiens)
RHEA:38329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol
RHEA:11662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O
RHEA:40388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
REACT:R-MMU-5654404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds SHC1 (Mus musculus)
RHEA:51792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + salicylate = 2,3-dihydroxybenzoate + H2O + NAD(+)
REACT:R-DME-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Drosophila melanogaster)
RHEA:58849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-hydroxygeranial + H(+) + NADH
RHEA:39117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+)
REACT:R-XTR-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Xenopus tropicalis)
REACT:R-DRE-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Danio rerio)
REACT:R-BTA-5251942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hikeshi binds HSP70s:ATP (Bos taurus)
RHEA:11057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 2 H(+) + NADPH + O2 => 4-aminophenol + CO2 + H2O + NADP(+)
REACT:R-HSA-447034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHL1 interacts with Ankyrin-G (Homo sapiens)
RHEA:67905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + H(+) + malonyl-[ACP] => 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA
REACT:R-BTA-8950518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Bos taurus)
REACT:R-CFA-70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Canis familiaris)
REACT:R-GGA-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Gallus gallus)
RHEA:13287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate => ATP + L-cysteine + L-glutamate
RHEA:17871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,7-dihydropteridine + H(+) + NADH => 5,6,7,8-tetrahydropteridine + NAD(+)
REACT:R-CFA-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Canis familiaris)
REACT:R-HSA-2984258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 phosphorylates NEK6/NEK7 (Homo sapiens)
RHEA:46882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:30483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]
RHEA:53428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]
GO:0030748	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tryptamine methyltransferase
GO:0030748	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:amine N-methyltransferase activity
GO:0030748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amine N-methyltransferase activity
GO:0030748	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tryptamine N-methyltransferase activity
GO:0030748	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	arylamine N-methyltransferase activity
GO:0030748	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nicotine N-methyltransferase activity
RHEA:66541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + A + H2O => AH2 + cholesta-5,7-dien-3beta,25-diol
RHEA:34621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11beta-hydroxypentalenate + CO2 + succinate => 1-deoxypentalenate + 2-oxoglutarate + O2
RHEA:64076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)
GO:0033758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clavaminate synthase activity
GO:0033758	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	clavaminate synthase 2 activity
GO:0033758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
GO:0033758	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	clavaminic acid synthase activity
REACT:R-BTA-9696179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Bos taurus)
RHEA:60783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A15 + O2 <=> CO2 + gibberellin A24 + H2O + succinate
REACT:R-DRE-9796691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPATA2 links CYLD to LUBAC (Danio rerio)
GO:0034789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity
REACT:R-GGA-2152276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of transmembrane collagens (Gallus gallus)
REACT:R-HSA-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Homo sapiens)
REACT:R-MMU-2064406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Mus musculus)
REACT:R-CEL-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)
GO:0050565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)
GO:0050565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H(+)
GO:0050565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aerobactin synthase activity
GO:0050565	skos:prefLabel	"aerobactin synthase"
GO:0050565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)
GO:0050565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aerobactin synthase"
REACT:R-RNO-913424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
REACT:R-DDI-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Dictyostelium discoideum)
GO:0050158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-5,6-dihydro-orotate:NAD oxidoreductase activity
GO:0050158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orotate reductase (NADPH) activity
GO:0050158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroorotate dehydrogenase (NADPH) activity
GO:0050158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotate reductase activity
GO:0050158	skos:prefLabel	"dihydroorotate dehydrogenase (NADP(+))"
GO:0050158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-dihydroorotate:NADP+ oxidoreductase activity
GO:0050158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate
GO:0050158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydro-orotic dehydrogenase activity
GO:0050158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroorotate dehydrogenase (NADP(+))"
REACT:R-MMU-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Mus musculus)
REACT:R-SSC-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Sus scrofa)
GO:0106356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)
GO:0106356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate 3-monooxygenase [NADPH] activity
REACT:R-SSC-3322016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Sus scrofa)
REACT:R-RNO-374331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bradykinin receptors B1 and B2 bind to bradykinin (Rattus norvegicus)
RHEA:38161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-capreomycidine + H2O => (2S,3S)-hydroxyarginine
GO:0008437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyrotropin-releasing hormone activity
GO:0008437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyrotropin releasing hormone activity
GO:0008437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRH activity
REACT:R-GGA-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Gallus gallus)
RHEA:28046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + propanoyl-CoA = CoA + propanoyl phosphate
RHEA:28046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphate propanoyltransferase"
RHEA:28046	skos:prefLabel	"phosphate propanoyltransferase"
REACT:R-DDI-73931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Dictyostelium discoideum)
REACT:R-XTR-9645481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIFA oligomerization (Xenopus tropicalis)
REACT:R-HSA-183084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Homo sapiens)
REACT:R-HSA-5632887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the RRM2B gene (Homo sapiens)
REACT:R-SSC-211950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 24-hydroxylates CTL (Sus scrofa)
GO:0016977	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitosan N-acetylglucosaminohydrolase activity
GO:0016977	skos:prefLabel	"chitosanase"
GO:0016977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chitosanase"
GO:0016977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitosanase activity
REACT:R-RNO-2066781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Rattus norvegicus)
REACT:R-CEL-199298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CREB1 (Caenorhabditis elegans)
RHEA:67588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)
RHEA:39879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol
REACT:R-SSC-71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Sus scrofa)
REACT:R-HSA-8876837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB21 GEFs exchange GTP for GDP on RAB21 (Homo sapiens)
REACT:R-XTR-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Xenopus tropicalis)
RHEA:12970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sn-glycero-3-phosphodiester + H2O => an alcohol + H(+) + sn-glycerol 3-phosphate
RHEA:45293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin G2 + AH2 => 2-glyceryl-prostaglandin H2 + A + H2O
GO:0008527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gustatory receptor
GO:0008527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taste receptor activity
REACT:R-DME-9038161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Drosophila melanogaster)
RHEA:23869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1-hydroxycyclohexan-1-yl)acetyl-CoA => acetyl-CoA + cyclohexanone
REACT:R-BTA-9674816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Bos taurus)
RHEA:16876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)
RHEA:24972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-DDI-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)
RHEA:58089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O => (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)
GO:0022870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose PTS transporter activity
GO:0022870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
EC:1.14.21.-	skos:prefLabel	"With NADH or NADPH as one donor, and the other dehydrogenated"
EC:1.14.21.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NADH or NADPH as one donor, and the other dehydrogenated"
REACT:R-SCE-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Saccharomyces cerevisiae)
REACT:R-SCE-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Saccharomyces cerevisiae)
REACT:R-DRE-202443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of CARMA1 (Danio rerio)
GO:0004377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity
GO:0004377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolipid 2-alpha-mannosyltransferase activity
GO:0004377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity
GO:0004377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligosaccharide-lipid mannosyltransferase activity
GO:0004377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase"
GO:0004377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
GO:0004377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity
GO:0004377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)
GO:0004377	skos:prefLabel	"GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase"
GO:0004377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose-oligosaccharide-lipid mannosyltransferase activity
REACT:R-GGA-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Gallus gallus)
RHEA:44679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + all-trans-retinol <=> a diacylglycerol + an all-trans-retinyl ester
REACT:R-GGA-2730664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Gallus gallus)
RHEA:61211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-nitro-cGMP + L-cysteinyl-[protein] <=> H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]
RHEA:36102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + S-adenosyl-L-methionine <=> methyl benzoate + S-adenosyl-L-homocysteine
RHEA:21082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + phosphate + S-adenosyl-L-methionine => ATP + H2O + L-methionine
RHEA:60905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 => 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
REACT:R-DDI-74247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)
REACT:R-GGA-2530573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREG(CR1L) binds to surface-bound C3 convertases (Gallus gallus)
REACT:R-MMU-2514772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Mus musculus)
REACT:R-HSA-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Homo sapiens)
REACT:R-GGA-372742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)
REACT:R-BTA-5654603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS3 (Bos taurus)
RHEA:14398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (4Z)-2-oxohept-4-enedioate + CO2
REACT:R-HSA-5686663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Completion of SSA (Homo sapiens)
RHEA:14180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-amygdalin + H2O <=> (R)-prunasin + D-glucose
REACT:R-CEL-6797627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPG hydrolyses L-Asn to L-Asp (Caenorhabditis elegans)
RHEA:69486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + H2O2 => dodecan-1-ol + O2
REACT:R-DRE-5621571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD209 binds ICAM2 (Danio rerio)
RHEA:26092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)
REACT:R-XTR-4090281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Xenopus tropicalis)
GO:0010011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	auxin binding
GO:0010011	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	auxin receptor
REACT:R-XTR-192475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Xenopus tropicalis)
REACT:R-RNO-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Rattus norvegicus)
EC:3.4.22.62	skos:altLabel	"CASP-9"
EC:3.4.22.62	skos:altLabel	"APAF-3"
EC:3.4.22.62	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-9"
EC:3.4.22.62	skos:altLabel	"ICE-LAP6"
EC:3.4.22.62	skos:altLabel	"apoptotic protease-activating factor 3"
EC:3.4.22.62	skos:altLabel	"apoptotic protease Mch-6"
EC:3.4.22.62	skos:prefLabel	"caspase-9"
EC:3.4.22.62	skos:altLabel	"ICE-like apoptotic protease 6"
REACT:R-BTA-191830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP nuclear import and release (Bos taurus)
RHEA:34642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + neopentalenolactone D
RHEA:65255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 6-hydroxymellein <=> diphosphate + verruculide C
RHEA:65825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:41297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoate + sphing-4-enine => H2O + N-(hexanoyl)sphing-4-enine
GO:0046941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	azetidine-2-carboxylic acid acetyltransferase activity
REACT:R-HSA-5662619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1H binds zinc (Homo sapiens)
EC:3.2.1.32	skos:altLabel	"xylanase"
EC:3.2.1.32	skos:altLabel	"xylan endo-1,3-beta-xylosidase"
EC:3.2.1.32	skos:prefLabel	"endo-1,3-beta-xylanase"
EC:3.2.1.32	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endo-1,3-beta-xylanase"
EC:3.2.1.32	skos:altLabel	"endo-1,3-beta-xylosidase"
GO:0015119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexose phosphate transmembrane transporter activity
GO:0003707	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid hormone receptor activity
GO:0003707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear steroid receptor activity
RHEA:44244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-HSA-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Homo sapiens)
RHEA:57558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-6810357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fillagrin and keratin intermediate filaments polymerise forming a network (Sus scrofa)
REACT:R-MMU-382061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular processing of novel PDGFs (Mus musculus)
REACT:R-MMU-9731661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Mus musculus)
RHEA:37416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA
REACT:R-DRE-9008052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10(?-152) binds IL1RAPL1 (Danio rerio)
REACT:R-MMU-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Mus musculus)
RHEA:25927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-8-ol <=> 8-hydroxyquinolin-2(1H)-one + AH2
RHEA:19271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-furoyl-CoA + AMP + diphosphate => 2-furoate + ATP + CoA
RHEA:11786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + NH4(+) + oxaloacetate => H2O + L-aspartate + NADP(+)
REACT:R-SSC-3221982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BANP binds TP53 (Sus scrofa)
REACT:R-DRE-5683964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates EYA1-4 (Danio rerio)
RHEA:60099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH
RHEA:45955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparaginyl-[protein] + UDP-alpha-D-glucose <=> H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP
RHEA:72464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]
REACT:R-CFA-2681667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Canis familiaris)
RHEA:37113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoyl-CoA + sphing-4-enine
REACT:R-DRE-6784734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds LDLR (Danio rerio)
REACT:R-DME-430311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rsu-1 interacts with Pinch1 (Drosophila melanogaster)
RHEA:59652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotetraono-1,5-lactone + H2O = D-xylotetraonate + H(+)
REACT:R-DME-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)
REACT:R-SSC-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Sus scrofa)
REACT:R-BTA-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Bos taurus)
REACT:R-HSA-9026771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEP hydrolyses MCTR2 to MCTR3 (Homo sapiens)
REACT:R-RNO-389986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Rattus norvegicus)
REACT:R-CEL-2162227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses (HA)2 (Caenorhabditis elegans)
REACT:R-RNO-5696119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Rattus norvegicus)
RHEA:40039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylaspartylglutamylglutamate synthase"
RHEA:40039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 L-glutamate + N-acetyl-L-aspartate = 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate
RHEA:40039	skos:altLabel	"NAAG synthetase II"
RHEA:40039	skos:altLabel	"N-acetylaspartylglutamylglutamate synthetase"
RHEA:40039	skos:prefLabel	"N-acetylaspartylglutamylglutamate synthase"
RHEA:40039	skos:altLabel	"NAAGS-II"
RHEA:13397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-oxohexanoate dehydrogenase"
RHEA:13397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxohexanoate + H2O + NADP(+) = 2 H(+) + hexanedioate + NADPH
RHEA:13397	skos:prefLabel	"6-oxohexanoate dehydrogenase"
RHEA:67253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonaldehyde + NAD(+) => 3-oxopropanoate + 2 H(+) + NADH
REACT:R-DRE-5423678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)
RHEA:22845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5693564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)
REACT:R-XTR-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Xenopus tropicalis)
RHEA:41550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine
REACT:R-HSA-9622667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBC3 gene expression is stimulated by FOXO3,(FOXO1) (Homo sapiens)
REACT:R-MMU-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Mus musculus)
RHEA:24190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxydibenzothiophene + H(+) + NADH => cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+)
REACT:R-MMU-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Mus musculus)
RHEA:57102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-1-thio-D-xylulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate
RHEA:53882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha,alpha-trehalose 6-phosphate + H(+) => ADP-alpha-D-glucose + D-glucose 6-phosphate
RHEA:51393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + serotonin => CoA + H(+) + N-(9Z-octadecenoyl)-serotonin
REACT:R-HSA-622310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD1 oligomerizes (Homo sapiens)
GO:0046998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-usnate reductase activity
GO:0046998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)
GO:0046998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-usnic acid dehydrogenase activity
RHEA:24973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:32278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(phosphooxy)-L-threonine + NAD(+) <=> 3-amino-2-oxopropyl phosphate + CO2 + NADH
REACT:R-MMU-1614460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of procollagen type VI (Mus musculus)
REACT:R-CFA-5669024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD70 binds CD27 (Canis familiaris)
RHEA:59747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]
RHEA:61075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-(R)-19-hydroxytabersonine + acetyl-CoA <=> (-)-(R)-19-O-acetyltabersonine + CoA
REACT:R-DME-380949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK is dephosphorylated (Drosophila melanogaster)
RHEA:20397	skos:altLabel	"O-succinylhomoserine (thiol)-lyase"
RHEA:20397	skos:altLabel	"cystathionine synthase"
RHEA:20397	skos:altLabel	"cystathionine synthetase"
RHEA:20397	skos:altLabel	"O-succinyl-L-homoserine succinate-lyase (adding cysteine)"
RHEA:20397	skos:prefLabel	"cystathionine gamma-synthase"
RHEA:20397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cystathionine gamma-synthase"
RHEA:20397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + O-succinyl-L-homoserine = H(+) + L,L-cystathionine + succinate
RHEA:20397	skos:altLabel	"O-succinylhomoserine synthase"
RHEA:20397	skos:altLabel	"O-succinylhomoserine synthetase"
RHEA:20397	skos:altLabel	"homoserine transsuccinylase"
REACT:R-HSA-904864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Homo sapiens)
RHEA:29397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+) + UMP => H2O + UTP
REACT:R-BTA-388596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanocortin receptors bind melanocortins (Bos taurus)
RHEA:12419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-CoA <=> acryloyl-CoA + NH4(+)
RHEA:35720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-versiconol acetate + H2O => (S)-versiconol + acetate + H(+)
GO:0160011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent protein decrotonylase activity
GO:0160011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:40309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenedioyl-CoA + AH2 => A + decanedioyl-CoA
REACT:R-BTA-8865482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KMT2A (MLL) binds RUNX1 (Bos taurus)
REACT:R-DDI-9714483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the ER membrane (Dictyostelium discoideum)
RHEA:11239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + spermidine <=> propane-1,3-diamine + sym-homospermidine
REACT:R-HSA-6791409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the CCNG1 gene (Homo sapiens)
REACT:R-HSA-2179291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
REACT:R-BTA-8952044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Bos taurus)
EC:1.6.7.-	skos:prefLabel	"With a iron-sulfur protein as acceptor"
EC:1.6.7.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a iron-sulfur protein as acceptor"
RHEA:16089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphoethanolamine = ethanolamine + phosphate
RHEA:67378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-histidine => glycyl-L-histidine + H2O
REACT:R-CFA-5632652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds CDON and PTCH (Canis familiaris)
REACT:R-HSA-3858480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT-dependent phosphorylation of DVL (Homo sapiens)
RHEA:21762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA
REACT:R-SSC-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Sus scrofa)
REACT:R-GGA-201521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK autophosphorylation downstream of PTN and MDK (Gallus gallus)
REACT:R-SSC-446083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD151 interacts with BP180 and the integrin alpha 6 subunit (Sus scrofa)
RHEA:17613	skos:prefLabel	"scyllo-inositol 2-dehydrogenase (NAD(+))"
RHEA:17613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scyllo-inositol 2-dehydrogenase (NAD(+))"
RHEA:17613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + scyllo-inositol = H(+) + NADH + scyllo-inosose
REACT:R-HSA-9707586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM oxidises LDL,HDL (Homo sapiens)
REACT:R-XTR-209815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is monoiodinated (Xenopus tropicalis)
RHEA:58820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biotin-dependent malonate decarboxylase"
RHEA:58820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonate + Na(+)(in) = acetate + CO2 + Na(+)(out)
RHEA:58820	skos:prefLabel	"biotin-dependent malonate decarboxylase"
RHEA:58820	skos:altLabel	"malonate decarboxylase"
RHEA:58820	skos:altLabel	"malonate carboxy-lyase (biotin-dependent)"
REACT:R-MMU-432143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM-1 binds PP2A (Mus musculus)
RHEA:56772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-adonixanthin + 2 O2 = 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O
RHEA:40726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + H2O <=> (9E)-octadecenoate + CoA + H(+)
REACT:R-CFA-8949580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F1Fo ATP synthase dimerizes (Canis familiaris)
RHEA:13554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose + ATP => ADP + alpha-D-galactose 1-phosphate + H(+)
RHEA:34565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-abequose + NADP(+)
REACT:R-SPO-1482689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)
RHEA:30591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)
RHEA:37023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-XTR-174425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Xenopus tropicalis)
REACT:R-MMU-209944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D binds GC (Mus musculus)
RHEA:39522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)
REACT:R-SSC-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Sus scrofa)
REACT:R-RNO-9749986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Rattus norvegicus)
RHEA:17342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH
REACT:R-DME-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Drosophila melanogaster)
RHEA:11267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 <=> H2O2 + NAD(+)
REACT:R-RNO-561253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A12 exchanges extracellular urate for cytosolic LACT (Rattus norvegicus)
RHEA:19393	skos:prefLabel	"lysine--pyruvate 6-transaminase"
RHEA:19393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + pyruvate = (S)-2-amino-6-oxohexanoate + L-alanine
RHEA:19393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine--pyruvate 6-transaminase"
RHEA:19393	skos:altLabel	"lysine--pyruvate 6-aminotransferase"
REACT:R-HSA-211951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1B1 4-hydroxylates EST17b (Homo sapiens)
REACT:R-GGA-9036307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPER:Heterotrimeric G-protein Gs binds ESTG (Gallus gallus)
RHEA:48891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione <=> (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
REACT:R-SSC-8858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF9 binds TNFRSF9 (Sus scrofa)
REACT:R-DRE-195418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-2 associates with VEGFR1 forming complexes on  cell surface (Danio rerio)
REACT:R-CEL-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Caenorhabditis elegans)
REACT:R-SPO-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Schizosaccharomyces pombe)
REACT:R-BTA-622415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 binds NEMO (Bos taurus)
REACT:R-DRE-9718394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide antagonists (Danio rerio)
RHEA:33389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine => cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine
RHEA:35694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-versicolorone + NADP(+) <=> 1'-hydroxyversicolorone + H(+) + NADPH
REACT:R-SSC-380927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK phosphorylates TSC1:TSC2 (Sus scrofa)
GO:0102584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity
RHEA:11497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + uracil => 3-(uracil-1-yl)-L-alanine + acetate + H(+)
GO:0034923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene-4,5-dicarboxylate decarboxylase activity
RHEA:43690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate => N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate
RHEA:61836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + H(+) + UDP
REACT:R-DME-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
REACT:R-SSC-2395364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP4 binds TGF-Beta-1 (Sus scrofa)
RHEA:31661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O
RHEA:20207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycasin + H(+) + UDP => methylazoxymethanol + UDP-alpha-D-glucose
REACT:R-BTA-2730882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC-theta (Bos taurus)
REACT:R-DME-8849908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM4 binds flotillin-1 (Drosophila melanogaster)
RHEA:10047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanol + NAD(+) <=> cyclohexanone + H(+) + NADH
GO:0102597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity
REACT:R-HSA-5654640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
REACT:R-RNO-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Rattus norvegicus)
REACT:R-HSA-9750016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)
REACT:R-BTA-5655193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIAA0101 double monoubiquitination (Bos taurus)
REACT:R-HSA-5218906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 phosphorylates MLKL (Homo sapiens)
RHEA:47428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) = 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH
RHEA:22551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)
REACT:R-RNO-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Rattus norvegicus)
RHEA:13477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan + NADP(+) = H(+) + indole-3-pyruvate + NADPH + NH4(+)
RHEA:44264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA
REACT:R-RNO-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Rattus norvegicus)
RHEA:71116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hispidin + NADH + O2 => 3-hydroxyhispidin + H2O + NAD(+)
REACT:R-CFA-453183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y348-SYK dissociates (Canis familiaris)
RHEA:18060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + Watasenia luciferin <=> CO2 + hnu + oxidized Watasenia luciferin
REACT:R-CFA-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)
REACT:R-CFA-174157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cyclin B (Canis familiaris)
REACT:R-SSC-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Sus scrofa)
RHEA:55182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylnonanoyl-CoA + O2
REACT:R-DRE-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Danio rerio)
RHEA:11938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 CO2 + 4 CoA + trans-resveratrol => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA
REACT:R-DRE-177671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Danio rerio)
REACT:R-RNO-5674496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate MAP2K1 (Rattus norvegicus)
RHEA:55961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate + ATP + CoA => AMP + diphosphate + gamma-butyrobetainyl-CoA
REACT:R-PFA-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Plasmodium falciparum)
EC:1.21.1.-	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
EC:1.21.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
RHEA:30867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-acetaldehyde + NAD(+) = (indol-3-yl)acetate + 2 H(+) + NADH
RHEA:65334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin E + H2O + NADP(+) => H(+) + NADPH + O2 + verruculide A
REACT:R-XTR-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Xenopus tropicalis)
RHEA:52680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-alpha-phenylglycine = CoA + H(+) + N-acetyl-L-alpha-phenylglycine
GO:0047394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity
GO:0047394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity
GO:0047394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity
GO:0047394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophosphoinositol inositolphosphodiesterase activity
GO:0047394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity
GO:0047394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity
GO:0047394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-cyclic-inositol-phosphate phosphodiesterase activity
GO:0047394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity
REACT:R-MMU-8940070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NAD+ (Mus musculus)
RHEA:15304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apiitol + NAD(+) <=> aldehydo-D-apiose + H(+) + NADH
REACT:R-XTR-5693533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C (ARTEMIS) processes DNA DSB ends (Xenopus tropicalis)
RHEA:42729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2791) in 21S rRNA => 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:50150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ethanol + H(+) => a fatty acid ethyl ester + H2O
REACT:R-MMU-8951951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds EP300 (Mus musculus)
RHEA:61825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pregnenolone + UDP-alpha-D-glucose => H(+) + pregnenolone 3-beta-D-glucoside + UDP
RHEA:20131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + D-ribose 5-phosphate => AMP + H2O
REACT:R-DRE-9611277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds P2RY12 antagonists (Danio rerio)
REACT:R-DME-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Drosophila melanogaster)
GO:0102409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-2-glycerol-3-phosphate C16:0-CoA acyl transferase activity
REACT:R-MMU-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Mus musculus)
RHEA:53436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:14702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CoA + NAD(+) => CoA-disulfide + H(+) + NADH
REACT:R-XTR-606289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	New CENPA-containing nucleosomes are deposited at the centromere (Xenopus tropicalis)
REACT:R-MMU-6782628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates STAM2:HGS (Mus musculus)
RHEA:63775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
REACT:R-HSA-201810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ligand trap binds the ligand BMP2, blocking BMP signalling (Homo sapiens)
REACT:R-SSC-2076220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
RHEA:12943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:49112	skos:prefLabel	"phenazine-1-carboxylate N-methyltransferase"
RHEA:49112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine
RHEA:49112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenazine-1-carboxylate N-methyltransferase"
REACT:R-HSA-140736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Homo sapiens)
REACT:R-HSA-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Homo sapiens)
REACT:R-HSA-1980067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 stimulates MYC transcription (Homo sapiens)
RHEA:61079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-minovincinine + acetyl-CoA <=> (-)-echitovenine + CoA
REACT:R-BTA-2028629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Bos taurus)
RHEA:47244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)
RHEA:69268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkenimidothioate = an alkenyl isothiocyanate + sulfate
REACT:R-GGA-5578966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A:AGO2:miRNA is transported into the nucleus (Gallus gallus)
REACT:R-MMU-4570485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO3 (Mus musculus)
REACT:R-GGA-879584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO3A1 isoform 1 has abroad substrate specificity (Gallus gallus)
RHEA:30628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) => (2S)-2-acetolactate + H(+) + NADH
REACT:R-DRE-888577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GABA by GAD2 (Danio rerio)
RHEA:54813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-7-isojasmonate + ATP + L-isoleucine => AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate
REACT:R-RNO-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Rattus norvegicus)
RHEA:64647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + propanoyl-CoA <=> butyl propanoate + CoA
REACT:R-DDI-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Dictyostelium discoideum)
REACT:R-SSC-5684875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR:ATRIP to RPA at resected DNA DSBs (Sus scrofa)
REACT:R-CFA-8981093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12 bound to IL12R internalises (Canis familiaris)
RHEA:47299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-BTA-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Bos taurus)
REACT:R-CEL-9014641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRSP12 deaminates 2AA to 2OBUTA (Caenorhabditis elegans)
REACT:R-CFA-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Canis familiaris)
RHEA:70726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sitosterol(out) <=> sitosterol(in)
REACT:R-CFA-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Canis familiaris)
REACT:R-CFA-5660980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S276-RELA binds RELB (Canis familiaris)
RHEA:11854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioadenosine
RHEA:28491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + K(+)(in) => H(+)(out) + K(+)(out)
REACT:R-BTA-1602377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Bos taurus)
REACT:R-DRE-9025152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Danio rerio)
REACT:R-MMU-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Mus musculus)
RHEA:66568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O = preluffariellolide A
REACT:R-SSC-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Sus scrofa)
REACT:R-CFA-2395764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atREs binds to nascent CM (Canis familiaris)
REACT:R-XTR-8944263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type II (Xenopus tropicalis)
REACT:R-SSC-71275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + glycine => ornithine + guanidoacetate (Sus scrofa)
RHEA:45831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH
EC:3.4.11.9	skos:altLabel	"proline aminopeptidase"
EC:3.4.11.9	skos:altLabel	"aminopeptidase P"
EC:3.4.11.9	skos:altLabel	"X-Pro aminopeptidase"
EC:3.4.11.9	skos:altLabel	"aminoacylproline aminopeptidase"
EC:3.4.11.9	skos:prefLabel	"Xaa-Pro aminopeptidase"
EC:3.4.11.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Xaa-Pro aminopeptidase"
REACT:R-HSA-2730894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
RHEA:47042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => 5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein]
RHEA:53605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycerol + phosphate
REACT:R-GGA-8853789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDNF,NRTN bind RET:GFRA1,GFRA2 (Gallus gallus)
GO:0052885	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinoid isomerohydrolase activity
GO:0052885	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinol isomerase activity
GO:0052885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	all-trans-retinylester 11-cis isomerohydrolase activity
GO:0052885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
GO:0052885	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	all-trans-retinol isomerase:hydrolase activity
GO:0052885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	all-trans-retinyl ester acylhydrolase, 11-cis retinol forming activity
REACT:R-HSA-9008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37, IL37(?-218) translocates from cytosol to extracellular region (Homo sapiens)
RHEA:69241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucoraphanin + H2O => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)
RHEA:68813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => beta-bisabolene + diphosphate
REACT:R-DDI-72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of eIF4E from the inactive eIF4E:4E-BP complex  (Dictyostelium discoideum)
REACT:R-DRE-5357780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Danio rerio)
REACT:R-SPO-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Schizosaccharomyces pombe)
REACT:R-MMU-1462041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNP1-4 are released into phagocytic vacuoles (Mus musculus)
REACT:R-BTA-8876446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ULK1 phosphorylates DENND3 (Bos taurus)
RHEA:18260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen III + 2 H(+) + O2 <=> 2 CO2 + 2 H2O + protoporphyrinogen IX
GO:0047907	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity
GO:0047907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	furylfuramide isomerase activity
REACT:R-SSC-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Sus scrofa)
EC:3.4.11.24	skos:prefLabel	"aminopeptidase S"
EC:3.4.11.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminopeptidase S"
EC:3.4.11.24	skos:altLabel	"SGAP"
EC:3.4.11.24	skos:altLabel	"double-zinc aminopeptidase"
RHEA:14129	skos:prefLabel	"12alpha-hydroxysteroid dehydrogenase"
RHEA:14129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"12alpha-hydroxysteroid dehydrogenase"
RHEA:14129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH
RHEA:23572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisovalerophenone
GO:0018819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactoyl-CoA = acryloyl-CoA + H2O
GO:0018819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)
GO:0018819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactoyl-CoA dehydratase activity
GO:0018819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactoyl-CoA hydro-lyase activity
GO:0018819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactoyl coenzyme A dehydratase activity
GO:0018819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactoyl-CoA dehydratase"
GO:0018819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactyl CoA dehydratase activity
GO:0018819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactyl-coenzyme A dehydrase activity
GO:0018819	skos:prefLabel	"lactoyl-CoA dehydratase"
GO:0018819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acrylyl coenzyme A hydratase activity
RHEA:40425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-RNO-193052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione isomerizes to progesterone (Rattus norvegicus)
RHEA:70004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] => cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-374723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nociceptin receptor binds to nociceptin (Homo sapiens)
REACT:R-DDI-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Dictyostelium discoideum)
REACT:R-MMU-5610763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Mus musculus)
RHEA:48344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + UDP-alpha-D-galactose = a D-galactosylceramide + H(+) + UDP
REACT:R-CFA-8931653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Canis familiaris)
RHEA:53620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = (-)-spiroviolene + diphosphate
RHEA:53620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-spiroviolene synthase"
RHEA:53620	skos:prefLabel	"(-)-spiroviolene synthase"
RHEA:57336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP
RHEA:54072	skos:prefLabel	"beta-thujene synthase"
RHEA:54072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = beta-thujene + diphosphate
RHEA:54072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-thujene synthase"
REACT:R-HSA-4656914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKBIA with SUMO1 (Homo sapiens)
REACT:R-DME-3209165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ID1 sequesters ETS2 (Drosophila melanogaster)
RHEA:68989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-CEL-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)
REACT:R-MMU-4088024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Mus musculus)
RHEA:55439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol
RHEA:58806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-ApG-3' + phosphate => 5'-pApG-3' + H2O
RHEA:31383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = lupeol
RHEA:31383	skos:prefLabel	"lupeol synthase"
RHEA:31383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lupeol synthase"
REACT:R-CFA-2187368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 (CHIP) ubiquitinates SMAD3 (Canis familiaris)
RHEA:58166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-epi-ent-eudesmane-5,11-diol + diphosphate => (2E,6E)-farnesyl diphosphate + 2 H2O
REACT:R-MMU-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)
RHEA:19709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-acylglycerol-3-phosphate O-acyltransferase"
RHEA:19709	skos:prefLabel	"1-acylglycerol-3-phosphate O-acyltransferase"
RHEA:19709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA
REACT:R-PFA-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Plasmodium falciparum)
RHEA:19736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) <=> bacteriochlorophyllide a + H(+) + NADH
RHEA:17685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + uracil 5-carboxylate = CO2 + uracil
RHEA:17685	skos:altLabel	"uracil-5-carboxylic acid decarboxylase"
RHEA:17685	skos:altLabel	"uracil-5-carboxylate carboxy-lyase"
RHEA:17685	skos:prefLabel	"uracil-5-carboxylate decarboxylase"
RHEA:17685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uracil-5-carboxylate decarboxylase"
REACT:R-SSC-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Sus scrofa)
RHEA:17966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) => (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O
RHEA:22511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) <=> diphosphate + DNA(n+1)
RHEA:15128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) <=> CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)
GO:0004859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase inhibitor activity
RHEA:11285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymalonate + NAD(+) => H(+) + NADH + oxomalonate
REACT:R-SSC-5671772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T38-PPP1R14A binds MLCP (Sus scrofa)
EC:3.2.1.15	skos:altLabel	"polygalacturonase"
EC:3.2.1.15	skos:altLabel	"pectinase"
EC:3.2.1.15	skos:prefLabel	"endo-polygalacturonase"
EC:3.2.1.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endo-polygalacturonase"
EC:3.2.1.15	skos:altLabel	"pectin depolymerase"
RHEA:37826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate
RHEA:28325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate
RHEA:28160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate
REACT:R-BTA-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Bos taurus)
GO:0030346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcineurin binding
GO:0030346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein phosphatase 3 binding
GO:0030346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphatase 2B binding
RHEA:29696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(I)inamide(in) => cob(I)inamide(out)
RHEA:62247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine(6-4)thymidine in DNA <=> a cytidine-thymine dinucleotide in DNA
RHEA:28739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)
RHEA:46450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr) => 2 L-tyrosyl-tRNA(Tyr)
GO:0004415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyalurononglucosaminidase activity
GO:0004415	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	chondroitinase activity
GO:0004415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyaluronoglucosaminidase activity
GO:0004415	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hyaluronidase activity
GO:0004415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hyaluronoglucosidase activity
GO:0004415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitinase I activity
GO:0004415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hyaluronate 4-glycanohydrolase activity
REACT:R-DRE-9731590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)
REACT:R-HSA-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Homo sapiens)
REACT:R-HSA-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Homo sapiens)
RHEA:42066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP + 2 diphosphate => ATP + GTP
RHEA:30541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitinyl-CoA => (R)-carnitinyl-CoA
REACT:R-XTR-8866283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBB recruits GPCRs into clathrin-coated pits (Xenopus tropicalis)
RHEA:45980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)
REACT:R-CEL-2046092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Caenorhabditis elegans)
REACT:R-XTR-210290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHIP (Xenopus tropicalis)
REACT:R-MMU-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Mus musculus)
RHEA:41789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + holo-[ACP] => acetyl-[ACP] + CoA
REACT:R-RNO-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Rattus norvegicus)
RHEA:16484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 S-adenosyl-L-methionine <=> 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine
GO:0045486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavanone 3-dioxygenase activity
GO:0045486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
GO:0045486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	naringenin 3-hydroxylase activity
GO:0045486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naringenin 3-dioxygenase activity
GO:0045486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavanone 3beta-hydroxylase activity
GO:0045486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavanone synthase I activity
GO:0045486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavanone 3-beta-hydroxylase activity
GO:0045486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavanone 3-hydroxylase activity
GO:0045486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
GO:0045486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S)-flavanone 3-hydroxylase activity
REACT:R-RNO-8985201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL (Rattus norvegicus)
RHEA:19211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	codeinone + H(+) + NADPH => codeine + NADP(+)
RHEA:57820	skos:altLabel	"PPK2D"
RHEA:57820	skos:prefLabel	"AMP-polyphosphate phosphotransferase"
RHEA:57820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + ADP = [phosphate](n+1) + AMP
RHEA:57820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"AMP-polyphosphate phosphotransferase"
RHEA:70010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + ATP + H(+) <=> 2-aminobenzoyl-AMP + diphosphate
RHEA:60374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose(in) => D-fructose(out)
REACT:R-BTA-8875659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Bos taurus)
RHEA:59474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gp(2'-5')Ap(3') + H(+) => 2',3'-cGAMP + H2O
REACT:R-MMU-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)
RHEA:50686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aniline + H(+) + L-glutamate => H2O + N(5)-phenyl-L-glutamine
REACT:R-BTA-9706312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to LCK (Bos taurus)
GO:0050266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rosmarinic acid synthase activity
GO:0050266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity
GO:0050266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity
GO:0050266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rosmarinate synthase activity
GO:0050266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity
RHEA:35810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-arabinonate <=> 2,5-dioxopentanoate + H2O
REACT:R-HSA-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Homo sapiens)
REACT:R-HSA-9023845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG binds to proximal and distal regions of the CTSD promoter (Homo sapiens)
REACT:R-BTA-4551604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO1 (Bos taurus)
REACT:R-BTA-4608854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 are recruited to the DVL2:PARD6A complex (Bos taurus)
REACT:R-CFA-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)
REACT:R-XTR-5654426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
RHEA:30538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinate sulfoxide + H(+) + NADPH <=> biotin + H2O + NADP(+)
REACT:R-GGA-264689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Gallus gallus)
GO:0018723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenanthrol sulfotransferase activity
GO:0018723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenanthrol sulphotransferase activity
REACT:R-XTR-430347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MigFilin associates with Filamin and F-actin (Xenopus tropicalis)
RHEA:71629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(out) + succinate(in) => phosphate(in) + succinate(out)
RHEA:49460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)
RHEA:49460	skos:prefLabel	"2-aminomuconate deaminase (2-hydroxymuconate-forming)"
RHEA:49460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-aminomuconate deaminase (2-hydroxymuconate-forming)"
RHEA:45544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
GO:0031751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D4 dopamine receptor binding
GO:0031751	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D4 dopamine receptor ligand
REACT:R-XTR-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)
REACT:R-MMU-159773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein S to protein S (Mus musculus)
RHEA:32691	skos:prefLabel	"(E)-beta-ocimene synthase"
RHEA:32691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(E)-beta-ocimene synthase"
RHEA:32691	skos:altLabel	"beta-ocimene synthase"
RHEA:32691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (E)-beta-ocimene + diphosphate
REACT:R-HSA-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Homo sapiens)
REACT:R-CFA-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Canis familiaris)
REACT:R-HSA-72127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal B Complex (Homo sapiens)
REACT:R-MMU-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Mus musculus)
REACT:R-SSC-5362448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh C-terminal fragments are degraded by the proteasome (Sus scrofa)
RHEA:33491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexacosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine
RHEA:41078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-SPO-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Schizosaccharomyces pombe)
REACT:R-GGA-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Gallus gallus)
RHEA:33954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribostamycin + UDP-N-acetyl-alpha-D-glucosamine <=> 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP
REACT:R-DRE-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Danio rerio)
REACT:R-XTR-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Xenopus tropicalis)
RHEA:37205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate
REACT:R-CFA-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Canis familiaris)
REACT:R-BTA-5653756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM25 binds monoUb:164-PCNA (Bos taurus)
REACT:R-RNO-9706298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CSK (Rattus norvegicus)
REACT:R-HSA-6786110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL13-bound IL13R type II (Homo sapiens)
REACT:R-DRE-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Danio rerio)
RHEA:47713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-3-hydroxy-L-proline => cis-3-hydroxy-D-proline
RHEA:65296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-4090288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate MBD1 with SUMO1 (Homo sapiens)
REACT:R-DRE-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Danio rerio)
REACT:R-SSC-156661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Exon Junction Complex (Sus scrofa)
RHEA:23563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate <=> adenosylcob(III)alamin 5'-phosphate + GMP + H(+)
REACT:R-SSC-199062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLRC1:KLRD1 heterodimer interacts with HLA-E (Sus scrofa)
RHEA:67783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
RHEA:55974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + ethyl acetate => acetyl-CoA + ethanol
RHEA:46050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosamine 1-phosphate => D-galactosamine 6-phosphate
REACT:R-CFA-353125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteosome degrades ODC holoenzyme complex (Canis familiaris)
RHEA:61217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)
GO:0034042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-foU DNA N-glycosylase activity
GO:0034042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyluracil DNA N-glycosylase activity
RHEA:14771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-6-hydroxynicotine + AH2 => (S)-nicotine + A + H2O
RHEA:15641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxaloacetate = CO2 + pyruvate
RHEA:25653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-oxobutanoate + H(+) = aminoacetone + CO2
REACT:R-BTA-201677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Bos taurus)
REACT:R-RNO-429815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation Of Bloc-1 Complex (Rattus norvegicus)
REACT:R-BTA-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Bos taurus)
RHEA:24952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anhydro-N-acetylmuramic acid kinase"
RHEA:24952	skos:altLabel	"anhMurNAc kinase"
RHEA:24952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate
RHEA:24952	skos:prefLabel	"anhydro-N-acetylmuramic acid kinase"
REACT:R-SPO-426130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Schizosaccharomyces pombe)
RHEA:49829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:15603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + (R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + (R)-3-phenyllactate
REACT:R-GGA-398040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma activation of PLC beta (Gallus gallus)
REACT:R-XTR-9696268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds effectors (Xenopus tropicalis)
RHEA:32230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-NADPHX <=> (6S)-NADPHX
RHEA:39559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA = (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O
GO:0002953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxynucleotidase activity
REACT:R-CEL-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Caenorhabditis elegans)
RHEA:70137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:14644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanurate + H2O <=> biuret + CO2
RHEA:25508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (1S,5S)-sabinene + diphosphate
RHEA:25508	skos:prefLabel	"(-)-sabinene synthase"
RHEA:25508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-sabinene synthase"
REACT:R-XTR-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Xenopus tropicalis)
RHEA:43186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2843) in 25S rRNA
RHEA:62794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + NADP(+) + nigerone => 3 H(+) + NADPH + O2 + 2 rubrofusarin B
REACT:R-BTA-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Bos taurus)
RHEA:40203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-9748979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Gallus gallus)
RHEA:25477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => alpha-himachalene + diphosphate
RHEA:72887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] = ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)
REACT:R-HSA-202709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 dimerises (Homo sapiens)
GO:0050270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylhomocysteine deaminase activity
GO:0050270	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-homocysteine aminohydrolase activity
GO:0050270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylhomocysteine deaminase activity
GO:0043858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine:ornithine antiporter activity
GO:0043858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine/ornithine antiporter activity
GO:0043858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine-ornithine antiporter activity
GO:0043858	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ArcD
GO:0043858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-ornithine(in) = L-arginine(in) + L-ornithine(out)
REACT:R-XTR-5626227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CP110 and CEP97 dissociate from the centriole (Xenopus tropicalis)
REACT:R-BTA-420592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectin-like (Necl) proteins (Bos taurus)
REACT:R-MMU-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Mus musculus)
REACT:R-SSC-381412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP2 binds IGF forming IGF:IGFBP2 (Sus scrofa)
GO:0015080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	silver ion transmembrane transporter activity
GO:0015080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	silver transporter activity
REACT:R-RNO-9624526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Rattus norvegicus)
REACT:R-HSA-2730858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of BTK/ITK (Homo sapiens)
RHEA:45561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine => D-allo-isoleucine
EC:7.4.2.5	skos:prefLabel	"bacterial ABC-type protein transporter"
EC:7.4.2.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacterial ABC-type protein transporter"
EC:7.4.2.5	skos:altLabel	"peptide-transporting ATPase"
REACT:R-HSA-8938314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPPs hydrolyse CoA-SH to PPANT, PAP (Homo sapiens)
REACT:R-MMU-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Mus musculus)
REACT:R-GGA-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Gallus gallus)
REACT:R-DRE-376123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM associates with Rac1-GTP:pPAK1 (Danio rerio)
RHEA:59186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetylphloroglucinol + acetate => 2,4-diacetylphloroglucinol + H2O
REACT:R-BTA-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Bos taurus)
REACT:R-DDI-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Dictyostelium discoideum)
REACT:R-CFA-8873794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCTP binds PC (Canis familiaris)
REACT:R-SSC-2089971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of collagens (Sus scrofa)
REACT:R-DME-8876837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB21 GEFs exchange GTP for GDP on RAB21 (Drosophila melanogaster)
REACT:R-DME-5655142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 binds POLH (Drosophila melanogaster)
REACT:R-HSA-983422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of COPII coated vesicle (Homo sapiens)
GO:0102457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity
REACT:R-DME-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Drosophila melanogaster)
REACT:R-XTR-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Xenopus tropicalis)
RHEA:56581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-thioguanine + S-adenosyl-L-methionine => 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine
RHEA:37376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA
RHEA:70415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dihydroxyphenyl)acetyl-CoA + H2O = (3,5-dihydroxyphenyl)acetate + CoA + H(+)
RHEA:62582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-cystine(in) + H(+) + phosphate => ATP + D-cystine(out) + H2O
RHEA:70861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(out) + L-glutamine(in) + Na(+)(in) => L-asparagine(in) + L-glutamine(out) + Na(+)(out)
RHEA:60066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+) => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2
REACT:R-CFA-5660666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBP and p300 binds NF-kB complex (Canis familiaris)
REACT:R-BTA-5654634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates SHC1 (Bos taurus)
REACT:R-HSA-9696980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike trimer glycoside chains get additional branches (Homo sapiens)
REACT:R-HSA-168092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) (Homo sapiens)
RHEA:12441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NAD(+) => 2-oxoglutarate + H(+) + L-lysine + NADH
REACT:R-CEL-71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer reduces PYR to LACT (Caenorhabditis elegans)
RHEA:44536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-1671687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR activation (Canis familiaris)
REACT:R-SPO-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Schizosaccharomyces pombe)
REACT:R-MMU-9008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds ESR1:estrogen:TGFA gene (Mus musculus)
GO:0102622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linuron hydrolase activity
GO:0102040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate reductase (menaquinone)
REACT:R-SSC-9015122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors bind Va:Xa (Sus scrofa)
RHEA:47912	skos:prefLabel	"6-deoxy-6-sulfo-D-gluconate dehydratase"
RHEA:47912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-deoxy-6-sulfo-D-gluconate dehydratase"
RHEA:47912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-gluconate = 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O
RHEA:47912	skos:altLabel	"SG dehydratase"
GO:0036403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonate 8(S)-lipoxygenase activity
GO:0036403	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	8-lipoxygenase (S-type)
GO:0036403	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	8(S)-lipoxygenase activity
RHEA:43732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O = 1,3-diacyl-sn-glycerol + a fatty acid + H(+)
REACT:R-SSC-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Sus scrofa)
REACT:R-HSA-430183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK binds PAK (Homo sapiens)
RHEA:50819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADPH <=> 5alpha-androstan-3,17-dione + NADP(+)
REACT:R-PFA-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Plasmodium falciparum)
RHEA:52014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA
RHEA:63235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H(+) + NADH <=> NAD(+) + octanoyl-CoA
REACT:R-HSA-374899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of noradrenaline  at the synapse (Homo sapiens)
GO:0102845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity
REACT:R-DRE-5607741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p52:RELB translocates from cytosol to nucleus (Danio rerio)
EC:3.6.1.58	skos:prefLabel	"8-oxo-dGDP phosphatase"
EC:3.6.1.58	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-oxo-dGDP phosphatase"
GO:0034722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-glutamyl-peptidase activity
GO:0034722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamyl hydrolase activity
RHEA:52002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione
RHEA:42323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-SSC-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Sus scrofa)
RHEA:61254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-valine + O2
REACT:R-CFA-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Canis familiaris)
GO:0102147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-O-methyltricetin O methyl transferase activity
GO:0102147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-O-methyltricetin + S-adenosyl-L-methionine = 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine
RHEA:15300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-RNO-8875490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind ubiquitinated MET (Rattus norvegicus)
GO:0099184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of postsynaptic intermediate filament cytoskeleton
GO:0005165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotrophin receptor binding
GO:0005165	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin
GO:0005165	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin receptor ligand
REACT:R-CFA-351894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of BAP31 (Canis familiaris)
REACT:R-CEL-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Caenorhabditis elegans)
REACT:R-XTR-5696049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRM hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)
RHEA:50727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxyphenylacetaldehyde oxime <=> (Z)-(4-hydroxyphenyl)acetaldehyde oxime
RHEA:49271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]
RHEA:16022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate => enol-oxaloacetate
REACT:R-HSA-8851827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Homo sapiens)
GO:0050258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavinase activity
GO:0050258	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin hydrolase activity
REACT:R-SSC-139905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAD protein to mitochondria (Sus scrofa)
REACT:R-DME-432455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PER is degraded by the 26S proteasome (Drosophila melanogaster)
RHEA:47598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP => an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
REACT:R-CEL-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Caenorhabditis elegans)
GO:0034924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity
RHEA:67081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acid(in) + ATP + H2O => a very long-chain fatty acid(out) + ADP + H(+) + phosphate
GO:0047170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity
GO:0047170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucarate O-hydroxycinnamoyltransferase activity
RHEA:16713	skos:prefLabel	"S-succinylglutathione hydrolase"
RHEA:16713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-succinylglutathione = glutathione + H(+) + succinate
RHEA:16713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-succinylglutathione hydrolase"
RHEA:42430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5R)-clavulanate-9-aldehyde => clavaminate
RHEA:34125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + olivetolate => 3,5,7-trioxododecanoyl-CoA
REACT:R-MMU-6814418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes formation of G-beta:G-gamma heterodimers (Mus musculus)
RHEA:64625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + acetyl-CoA => (2E)-geranyl acetate + CoA
REACT:R-HSA-6804955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDM2 (Homo sapiens)
RHEA:51217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one => adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)
REACT:R-CFA-1008200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 binds the beta globin locus control region (Canis familiaris)
REACT:R-CEL-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Caenorhabditis elegans)
REACT:R-HSA-420131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PACAP receptor binds PACAP (Homo sapiens)
RHEA:43272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GD2 + H(+) + UDP
REACT:R-SSC-8869568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM1 binds TFAP2A homodimer (Sus scrofa)
REACT:R-CEL-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-DRE-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Danio rerio)
RHEA:25211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine
GO:0033842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta1,4-N-acetylgalactosaminyltransferase activity
GO:0033842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta1,4-N-acetylgalactosaminyltransferase IV activity
GO:0033842	skos:prefLabel	"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase"
GO:0033842	skos:altLabel	"beta1,4-N-acetylgalactosaminyltransferase"
GO:0033842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
GO:0033842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity
GO:0033842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta4GalNAc-T4
GO:0033842	skos:altLabel	"beta4GalNAc-T3"
GO:0033842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity
GO:0033842	skos:altLabel	"beta4GalNAc-T4"
GO:0033842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase"
GO:0033842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta1,4-N-acetylgalactosaminyltransferase III activity
GO:0033842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta4GalNAc-T3
RHEA:58887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 <=> A + chloramphenicol + 2 H2O
REACT:R-DDI-9014052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin3 (Dictyostelium discoideum)
RHEA:51550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine => (R)-tetrahydropapaverine + S-adenosyl-L-methionine
GO:0046983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein dimerization activity
REACT:R-HSA-873919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Homo sapiens)
REACT:R-GGA-8878220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the NOTCH1 coactivator complex (Gallus gallus)
REACT:R-SSC-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Sus scrofa)
REACT:R-BTA-171122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL + LDLR => LDL:LDLR complex (Bos taurus)
GO:0106222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long noncoding RNA binding
GO:0106222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lncRNA binding
RHEA:23095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + hydroxyatrazine <=> ethylamine + N-isopropylammelide
RHEA:47862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)) + H2O
RHEA:50077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:3.4.22.6	skos:prefLabel	"chymopapain"
EC:3.4.22.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chymopapain"
EC:3.4.22.6	skos:altLabel	"Papaya proteinase II"
RHEA:60035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GTP + H2O <=> 8-oxo-GDP + H(+) + phosphate
REACT:R-SSC-8876472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 binds CHOL (Sus scrofa)
GO:0005476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine:acyl carnitine antiporter activity
GO:0005476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine:acyl carnitine carrier activity
GO:0005476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine/acyl carnitine carrier activity
GO:0005476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acyl carnitine carrier
RHEA:14519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => (E)-feruloyl-CoA + H2O
GO:0140937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4-K12 deacetylase activity
GO:0140937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K12 deacetylase activity
GO:0140937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H4-K12 deacetylation
GO:0140937	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H4K12 deacetylation
GO:0140937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone deacetylase activity (H4-K12 specific)
REACT:R-CFA-174251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Canis familiaris)
REACT:R-DRE-8869506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Danio rerio)
RHEA:38345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + D-glucose => (20S)-ginsenoside Rd + H2O
RHEA:69102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-kynurenine
RHEA:71927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauroursodeoxycholate(out) = 2 Na(+)(in) + tauroursodeoxycholate(in)
RHEA:24427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + L-dehydroascorbate <=> glutathione disulfide + L-ascorbate
REACT:R-MMU-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
REACT:R-XTR-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)
EC:1.9.99.-	skos:prefLabel	"With other acceptors"
EC:1.9.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
RHEA:26547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alaninamide + H2O => beta-alanine + NH4(+)
RHEA:63464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + UTP = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP
RHEA:56369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)
GO:0080161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	auxin transmembrane transporter activity
RHEA:62999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienamide + H2O <=> (8Z,11Z,14Z)-eicosatrienoate + NH4(+)
REACT:R-BTA-1250189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)
RHEA:72355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
REACT:R-HSA-2465926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An atROL isomerase isomerises atROL to 11cROL (Homo sapiens)
RHEA:70808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-sulfo-D-erythrose => 4-deoxy-4-sulfo-D-erythrulose
REACT:R-DDI-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Dictyostelium discoideum)
REACT:R-SPO-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Schizosaccharomyces pombe)
RHEA:36057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,4-dihydroxypteridine + NH4(+) => a 2-amino-4-hydroxypteridine + H(+) + H2O
RHEA:36856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-L-cysteine-S-conjugate + H2O => acetate + an S-substituted L-cysteine
REACT:R-HSA-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Homo sapiens)
REACT:R-SCE-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Saccharomyces cerevisiae)
REACT:R-HSA-2737728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants (Homo sapiens)
REACT:R-SSC-9027628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises EPA to 5-HEPE (Sus scrofa)
REACT:R-XTR-177939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)
REACT:R-MMU-425822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Mus musculus)
REACT:R-MMU-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Mus musculus)
REACT:R-BTA-873924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IFNGR1 by JAK kinases (Bos taurus)
RHEA:31236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate => (4R)-4-hydroxy-2-oxoglutarate + L-glutamate
REACT:R-DRE-2327695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Danio rerio)
RHEA:35016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin(in) => riboflavin(out)
RHEA:61736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP
REACT:R-XTR-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Xenopus tropicalis)
RHEA:63574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + neurotensin-(1-7) => H2O + neurotensin-(1-8)
REACT:R-SSC-193641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKK-beta is recruited (Sus scrofa)
REACT:R-RNO-1297444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of cAMP to HCN channels (Rattus norvegicus)
RHEA:65695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine <=> a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine
RHEA:11380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[2-(trimethylamino)ethyl]phosphonate dioxygenase"
RHEA:11380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate
RHEA:11380	skos:prefLabel	"[2-(trimethylamino)ethyl]phosphonate dioxygenase"
RHEA:39596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)
REACT:R-MMU-3215295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates MDM2 (Mus musculus)
RHEA:63279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-XTR-5610735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB binds ITCH (Xenopus tropicalis)
RHEA:28711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) = H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)
REACT:R-DME-373724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds NCK (Drosophila melanogaster)
RHEA:29416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(in) + H(+)(in) => (S)-lactate(out) + H(+)(out)
GO:0102664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-leucine synthetase activity
REACT:R-HSA-191062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of Klotho-bound FGFR1c (Homo sapiens)
REACT:R-BTA-5617829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of IFT A complex (Bos taurus)
RHEA:65772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-444647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3a receptor binds anaphylatoxin C3a (Mus musculus)
REACT:R-DME-432401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JET binds cytosolic TIM, facilitating its ubiquitination (Drosophila melanogaster)
REACT:R-RNO-8963915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D binds VDR (Rattus norvegicus)
REACT:R-BTA-8848726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates BCAR1 (Bos taurus)
RHEA:51771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate <=> 4-prenylphlormethylbutanophenone + diphosphate
RHEA:31576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+)
RHEA:60674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + neral => NAD(+) + nerol
RHEA:54824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycoprotein endo-alpha-1,2-mannosidase"
RHEA:54824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] = alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)
RHEA:54824	skos:prefLabel	"glycoprotein endo-alpha-1,2-mannosidase"
RHEA:54824	skos:altLabel	"endo-alpha-D-mannosidase"
REACT:R-CFA-191972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)
REACT:R-SSC-9627104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP3 (Sus scrofa)
REACT:R-CFA-75010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser 216 by Chk1 (Canis familiaris)
RHEA:17448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0042015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-20 binding
GO:0042015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-20 binding
RHEA:62502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + L-arginyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-arginyl-AMP
RHEA:35621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate => L-idarate
REACT:R-BTA-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Bos taurus)
REACT:R-SSC-9036987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Sus scrofa)
RHEA:31546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 UDP-alpha-D-glucose <=> 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)
RHEA:50531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]
RHEA:47874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 + N-acetylneuraminate => ganglioside GM1 + H2O
RHEA:29165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out) => 2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out)
RHEA:53214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:14347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + tyramine => H(+) + L-tyrosine
RHEA:15166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + sarcosine => glyoxylate + H2O2 + methylamine
REACT:R-HSA-265426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Tenascin (Homo sapiens)
GO:0062240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	euchromatin-nuclear membrane tether activity
GO:0062240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane-euchromatin anchor activity
GO:0062240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	euchromatin-nuclear membrane anchor activity
GO:0062240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane-euchromatin tether activity
GO:0035091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol binding
GO:0035091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoinositide binding
REACT:R-MMU-374669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds NRP1 (Mus musculus)
RHEA:40235	skos:prefLabel	"fumarate reductase (CoM/CoB)"
RHEA:40235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumarate reductase (CoM/CoB)"
RHEA:40235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + fumarate = coenzyme M-coenzyme B heterodisulfide + succinate
RHEA:40235	skos:altLabel	"thiol:fumarate reductase"
REACT:R-GGA-877361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyrin binds ASC (Gallus gallus)
REACT:R-GGA-933531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-IRF7:p-IRF7 to nucleus (Gallus gallus)
RHEA:19203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dGMP + H(+) => 2'-deoxyguanosine + ATP
REACT:R-DME-2032770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1 to the nucleus (Drosophila melanogaster)
RHEA:58600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine
REACT:R-CFA-174448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex on the C-strand of the telomere (Canis familiaris)
GO:0031765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 galanin receptor binding
GO:0031765	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 galanin receptor ligand
REACT:R-RNO-6807144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Rattus norvegicus)
RHEA:67716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 oxidized [2Fe-2S]-[protein] = H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]
RHEA:50042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O
REACT:R-RNO-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Rattus norvegicus)
RHEA:50418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein]
REACT:R-CFA-210290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHIP (Canis familiaris)
REACT:R-CFA-8875902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC45A3 transports Glc from extracellular region to cytosol (Canis familiaris)
REACT:R-MMU-200318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Mus musculus)
REACT:R-RNO-9678766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 binds CYP3A4 inhibitors (Rattus norvegicus)
REACT:R-HSA-9694579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
REACT:R-SSC-879377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Sus scrofa)
RHEA:25660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Sus scrofa)
RHEA:49446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetate + CoA + H(+) => (2-aminobenzoyl)acetyl-CoA + H2O
RHEA:58797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 7-O-beta-D-glucoside + malonyl-CoA => a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA
RHEA:15146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose => alpha,alpha-trehalose
REACT:R-RNO-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Rattus norvegicus)
REACT:R-RNO-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
RHEA:56863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate <=> a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]
RHEA:40636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate
REACT:R-HSA-1791054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GSK3A (Homo sapiens)
REACT:R-MMU-9646348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Mus musculus)
REACT:R-CFA-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Canis familiaris)
REACT:R-XTR-110364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Xenopus tropicalis)
REACT:R-HSA-180634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand (Homo sapiens)
REACT:R-RNO-391377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone receptor can bind LH (Rattus norvegicus)
REACT:R-SSC-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Sus scrofa)
GO:0106276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin IXalpha + NAD(+) = biliverdin IXalpha + H(+) + NADH
GO:0106276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliberdin reductase NAD+ activity
REACT:R-GGA-390598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Gallus gallus)
REACT:R-MMU-9796379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Mus musculus)
REACT:R-RNO-9632906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ recruits RAS in response to estrogen stimulation (Rattus norvegicus)
REACT:R-DRE-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Danio rerio)
RHEA:58530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(16R)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH
REACT:R-RNO-429581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 transports vitamins from extracellular region to cytosol (Rattus norvegicus)
RHEA:69389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + carbamoyl phosphate => allantoate + H(+) + phosphate
REACT:R-SSC-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Sus scrofa)
REACT:R-MMU-450358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Mus musculus)
RHEA:42256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanoyl-CoA + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + CoA
REACT:R-RNO-2197698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src phosphorylate WASP,N-WASP (Rattus norvegicus)
RHEA:59671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellohexaose + O2 <=> D-cellohexaono-1,5-lactone + H2O2
REACT:R-SSC-8936519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO2:FAD dimer reduces quinones to hydroquinones (Sus scrofa)
REACT:R-SCE-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Saccharomyces cerevisiae)
RHEA:59092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mutansucrase"
RHEA:59092	skos:prefLabel	"mutansucrase"
RHEA:59092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n) + sucrose = [(1->3)-alpha-D-glucosyl](n+1) + D-fructose
REACT:R-HSA-9686699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion and Release of SARS-CoV-1 Nucleocapsid (Homo sapiens)
RHEA:59665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellopentaose + O2 => D-cellopentaono-1,5-lactone + H2O2
REACT:R-HSA-5668789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LA,TNFSF14 binds LTBR (Homo sapiens)
REACT:R-MMU-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Mus musculus)
REACT:R-HSA-201648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)
RHEA:44935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate
REACT:R-HSA-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Homo sapiens)
RHEA:72502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + prostaglandin E2(out) <=> 2-oxoglutarate(out) + prostaglandin E2(in)
RHEA:49958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + phenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate + O2
REACT:R-CEL-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Caenorhabditis elegans)
REACT:R-MMU-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Mus musculus)
REACT:R-GGA-140851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Gallus gallus)
RHEA:53109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine
RHEA:13950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [rubredoxin] => NADPH + 2 oxidized [rubredoxin]
RHEA:35905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA
REACT:R-HSA-1791139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SRPR (SRP Receptor subunit alpha) (Homo sapiens)
EC:1.18.3.-	skos:prefLabel	"With H(+) as acceptor"
EC:1.18.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With H(+) as acceptor"
RHEA:69962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:46944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) = H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH
RHEA:72217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(in) + Na(+)(in) => 2 hydrogencarbonate(out) + Na(+)(out)
RHEA:34205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aureusidin 6-O-beta-glucoside + H2O => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2
RHEA:36286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,7-dimethylxanthine + H(+) + NADPH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)
RHEA:70756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-9024983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Dictyostelium discoideum)
REACT:R-DRE-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Danio rerio)
REACT:R-BTA-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)
RHEA:23887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide + S-adenosyl-L-methionine <=> 1-methylnicotinamide + S-adenosyl-L-homocysteine
RHEA:22591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal <=> 1-pyrroline + H2O
RHEA:45513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]
REACT:R-BTA-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Bos taurus)
RHEA:48198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA => H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein]
RHEA:53471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:59033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:46045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-octenoyl-CoA => (2E)-octenoyl-CoA
RHEA:44156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 5-phosphate + H2O = myo-inositol + phosphate
REACT:R-MMU-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Mus musculus)
RHEA:18674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[receptor-protein] => ADP + H(+) + O-phospho-L-seryl-[receptor-protein]
REACT:R-HSA-5357429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL autophosphorylates on Y772 and Y814 (Homo sapiens)
REACT:R-CFA-210881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Tie2/Ang1 complex (Canis familiaris)
REACT:R-MMU-983285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B binds RAD51C (Mus musculus)
RHEA:15431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine => heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine
REACT:R-HSA-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Homo sapiens)
REACT:R-DME-193452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Drosophila melanogaster)
REACT:R-BTA-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Bos taurus)
REACT:R-XTR-390886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH4 binds Hist (Xenopus tropicalis)
RHEA:19467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2
REACT:R-DRE-1855162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Danio rerio)
REACT:R-MMU-432952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP180 interacts intracellularly with plectin and integrin beta4 (Mus musculus)
REACT:R-XTR-140783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Xenopus tropicalis)
RHEA:34735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)
REACT:R-HSA-379992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)
REACT:R-BTA-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Bos taurus)
REACT:R-CFA-6799196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Canis familiaris)
RHEA:63682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+) => (7R,8S)-7,8-diammoniononanoate + CO2
RHEA:54163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate
RHEA:32864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-SCE-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Saccharomyces cerevisiae)
REACT:R-SPO-8869633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NR to yield NMN (Schizosaccharomyces pombe)
REACT:R-HSA-201630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Acinus (Homo sapiens)
REACT:R-DRE-1295613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds GRB2 (Danio rerio)
REACT:R-HSA-217258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO2:FAD:Mg2+ S-oxidises MTZ (Homo sapiens)
RHEA:32766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-methyl-D-ornithine + ATP + L-lysine <=> (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate
RHEA:57021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apulose + ATP => ADP + apulose 4-phosphate + H(+)
RHEA:39366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O
EC:4.6.1.25	skos:prefLabel	"bacteriophage T4 restriction endoribonuclease RegB"
EC:4.6.1.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacteriophage T4 restriction endoribonuclease RegB"
RHEA:27782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate
RHEA:13667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP + diphosphate => GTP
REACT:R-SPO-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Schizosaccharomyces pombe)
REACT:R-MMU-8951595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Mus musculus)
REACT:R-RNO-9758674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 oxidizes PREDN,PREDL (Rattus norvegicus)
REACT:R-HSA-1483107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPETA is hydrolyzed to ETA and G3P by GPCPD1 (Homo sapiens)
RHEA:35543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphooxypyruvate + H2O = 3-hydroxypyruvate + phosphate
RHEA:37581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine
RHEA:19703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP => a flavonol 3-O-glycoside + UDP-alpha-D-xylose
RHEA:22980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
RHEA:22980	skos:prefLabel	"dolichyl-diphosphooligosaccharide--protein glycotransferase"
RHEA:22980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-diphosphooligosaccharide--protein glycotransferase"
RHEA:22980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]
REACT:R-DRE-5607744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 binds BCL10 (Danio rerio)
REACT:R-DRE-9009950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE12 cleaves 2'-5' oligoadenylates  (Danio rerio)
RHEA:13882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + an aldehyde + H2O => a carboxylate + a quinol + H(+)
REACT:R-HSA-419087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIM kinase phosphorylation by ROCK (Homo sapiens)
REACT:R-HSA-9009554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer:SDC1 binds CSF1R (Homo sapiens)
RHEA:70641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+)
GO:0061660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0061660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Atg12 ligase activity
RHEA:51799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycohumulone + dimethylallyl diphosphate <=> colupulone + diphosphate + H(+)
REACT:R-GGA-5683930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WICH phosphorylates H2AFX on Y142 (Gallus gallus)
REACT:R-SSC-934559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is phosphorylated by phosphorylated MNK1 (Sus scrofa)
RHEA:33878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z-octadecenoate) + H2O <=> (9Z)-octadecenoate + cholesterol + H(+)
REACT:R-DRE-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Danio rerio)
RHEA:26299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O => 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH
REACT:R-GGA-350319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of vimentin at IDVD (259) (Gallus gallus)
RHEA:66020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O
GO:0070251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate:CoA ligase (AMP-forming)
GO:0070251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanoyl-CoA ligase activity
GO:0070251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate-CoA ligase activity
REACT:R-CFA-1977958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with ERBB3 (Canis familiaris)
REACT:R-RNO-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Rattus norvegicus)
REACT:R-CEL-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)
RHEA:59973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + L-seryl-[protein] => CoA + O-decanoyl-L-seryl-[protein]
REACT:R-MMU-183122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3b-bound Factor B (Mus musculus)
REACT:R-SPO-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Schizosaccharomyces pombe)
REACT:R-XTR-5685902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Xenopus tropicalis)
GO:1990003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine diphosphatase activity
GO:1990003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDP phosphatase activity
GO:1990003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDPase activity
GO:1990003	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	IDP diphosphatase activity
GO:1990003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine-diphosphatase activity
RHEA:44564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate
EC:3.4.23.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspergillopepsin II"
EC:3.4.23.19	skos:altLabel	"Aspergillus niger var. macrosporus aspartic proteinase"
EC:3.4.23.19	skos:altLabel	"proteinase A"
EC:3.4.23.19	skos:altLabel	"proctase A"
EC:3.4.23.19	skos:prefLabel	"aspergillopepsin II"
REACT:R-XTR-1912394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 in complex with RBPJ (CSL) recruits MAML (Xenopus tropicalis)
RHEA:69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-tryptophan <=> glycine + indole-3-pyruvate
REACT:R-HSA-9641109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Homo sapiens)
REACT:R-SSC-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Sus scrofa)
RHEA:42964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(54/55) in tRNA = pseudouridine(54/55) in tRNA
RHEA:72941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + propanoate(in) => 2 Na(+)(out) + propanoate(out)
GO:0070739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glutamate ligase activity
GO:0070739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glutamic acid ligase activity
GO:0070739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein glutamylase activity
REACT:R-DRE-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Danio rerio)
GO:0018826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methioninase activity
GO:0018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine gamma-lyase activity
GO:0018826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine lyase activity
GO:0018826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)
GO:0018826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methioninase activity
GO:0018826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine methanethiol-lyase (deaminating)
GO:0018826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine dethiomethylase activity
GO:0018826	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine gamma-lyase activity
REACT:R-BTA-159728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-prothrombin to prothrombin (Bos taurus)
REACT:R-MMU-706479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated (Mus musculus)
RHEA:14965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl phosphate + H2O = a carboxylate + H(+) + phosphate
RHEA:14965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acylphosphatase"
RHEA:14965	skos:prefLabel	"acylphosphatase"
RHEA:14965	skos:altLabel	"acylphosphate phosphohydrolase"
RHEA:55348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol = 9-cis-retinol
REACT:R-DRE-909725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IRF9 with p-STAT2:p-STAT1 (Danio rerio)
REACT:R-DRE-3132753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pancreatic proteases degrade TCN1:RCbl (Danio rerio)
EC:2.3.1.251	skos:prefLabel	"lipid IVA palmitoyltransferase"
EC:2.3.1.251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipid IVA palmitoyltransferase"
RHEA:51367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine <=> CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine
REACT:R-GGA-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Gallus gallus)
REACT:R-MMU-9759169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Mus musculus)
RHEA:22408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylallyltranstransferase"
RHEA:22408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate
RHEA:22408	skos:altLabel	"dimethylallyltransferase"
RHEA:22408	skos:altLabel	"geranyl-diphosphate synthase"
RHEA:22408	skos:prefLabel	"dimethylallyltranstransferase"
RHEA:22408	skos:altLabel	"prenyltransferase"
REACT:R-RNO-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Rattus norvegicus)
REACT:R-CFA-5333671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCAs self cleave (Canis familiaris)
REACT:R-PFA-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)
RHEA:42632	skos:prefLabel	"23S rRNA (adenine(2503)-C(8))-methyltransferase"
RHEA:42632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (adenine(2503)-C(8))-methyltransferase"
RHEA:42632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine
REACT:R-SSC-417908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY1 binds ADP (Sus scrofa)
REACT:R-DRE-5649734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates NEIL1,NEIL2-generated single strand break (Danio rerio)
REACT:R-XTR-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Xenopus tropicalis)
REACT:R-HSA-9648114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 recruits NUDC to mitotic spindle (Homo sapiens)
REACT:R-RNO-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Rattus norvegicus)
REACT:R-GGA-265823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association between RAD9 and TopBP1 (Gallus gallus)
RHEA:41380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene = 4-methylphenol + H2O + NAD(+)
RHEA:41380	skos:prefLabel	"toluene 4-monooxygenase"
RHEA:41380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"toluene 4-monooxygenase"
RHEA:41380	skos:altLabel	"TMO"
REACT:R-CFA-2453833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Canis familiaris)
REACT:R-BTA-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Bos taurus)
RHEA:51859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
RHEA:10653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + H2O + NAD(+) => a long-chain fatty acid + 2 H(+) + NADH
REACT:R-BTA-5654692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
REACT:R-GGA-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Gallus gallus)
RHEA:56446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:37193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 2'-phosphate + H(+) => 2',3'-cyclophospho-AMP + H2O
REACT:R-CEL-70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate + H2O => 4-imidazolone-5-propionate (Caenorhabditis elegans)
REACT:R-DRE-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Danio rerio)
REACT:R-GGA-1168635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (PKC-beta) phosphorylates CARMA1 (Gallus gallus)
REACT:R-CFA-8876616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND6A,B exchange GTP for GDP on RAB14 (Canis familiaris)
RHEA:29560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP
RHEA:31263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	but-3-ynal + H(+) + pyrroloquinoline quinol = but-3-yn-1-ol + pyrroloquinoline quinone
RHEA:22910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic IMP + NH4(+) => 3',5'-cyclic AMP + H(+) + H2O
EC:3.4.24.26	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudolysin"
EC:3.4.24.26	skos:altLabel	"Pseudomonas aeruginosa neutral metalloproteinase"
EC:3.4.24.26	skos:altLabel	"Pseudomonas elastase"
EC:3.4.24.26	skos:prefLabel	"pseudolysin"
REACT:R-HSA-2466367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)
GO:0061980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	regulatory RNA binding
REACT:R-HSA-9033505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)
GO:0005295	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium/neutral amino acid transporter
GO:0005295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral amino acid:sodium symporter activity
GO:0005295	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	neutral amino acid-sodium cotransporter
GO:0005295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral L-amino acid:sodium symporter activity
GO:0050457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)
GO:0050457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decylcitrate synthase activity
GO:0050457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity
GO:0050457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)
GO:0050457	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-decylcitrate synthase activity
RHEA:10575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vinylacetyl-CoA <=> (2E)-butenoyl-CoA
RHEA:59486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+) => arsenite + 2 Fe(III)-[cytochrome c] + H2O
RHEA:62245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine(6-4)thymidine in DNA => a cytidine-thymine dinucleotide in DNA
REACT:R-CFA-71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Canis familiaris)
REACT:R-DRE-6810474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Danio rerio)
REACT:R-RNO-166542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-NGF dimer binds to TrkA receptor (Rattus norvegicus)
RHEA:70051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate
REACT:R-DME-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Drosophila melanogaster)
REACT:R-MMU-2186643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEN1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)
REACT:R-SSC-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Sus scrofa)
RHEA:69200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate
RHEA:32753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline(in) => choline(out)
REACT:R-BTA-8950441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Bos taurus)
REACT:R-DME-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Drosophila melanogaster)
REACT:R-HSA-9758604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
RHEA:36165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate
REACT:R-SCE-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Saccharomyces cerevisiae)
RHEA:40739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb2 + 2 H2O = (20S)-ginsenoside C-Y + 2 D-glucose
RHEA:64281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-phenylethylamine + pyruvate => acetophenone + L-alanine
GO:0015024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronate-2-sulfatase activity
GO:0015024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronate-2-sulphatase activity
GO:0015024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondro-2-sulfatase activity
GO:0015024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucurono-2-sulfatase activity
GO:0015024	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity
REACT:R-HSA-9680811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp12 binds nsp7 and nsp8 (Homo sapiens)
REACT:R-HSA-8874206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L3 (Homo sapiens)
REACT:R-RNO-3000411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates PML with SUMO2 (Rattus norvegicus)
RHEA:11714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:20757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + D-threo-isocitrate => 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA
REACT:R-RNO-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)
RHEA:59734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein] => biotinyl-5'-AMP + L-lysyl-[protein]
REACT:R-HSA-2197588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD2 binds RBPJ and MAML in the nucleus (Homo sapiens)
REACT:R-RNO-2214330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of collagen VII NC2 region by BMP1 (Rattus norvegicus)
REACT:R-HSA-5668543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3:NIK binds TRAF2:cIAP1/2 (Homo sapiens)
RHEA:65849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-Delta(1)-steroid + H2O => a steroid 1,3-dione + AH2
REACT:R-DDI-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Dictyostelium discoideum)
REACT:R-MMU-190782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of connexon-containing transport vesicles from the Golgi (Mus musculus)
REACT:R-MMU-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Mus musculus)
REACT:R-DRE-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Danio rerio)
REACT:R-HSA-165179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TSC1:TSC2 complex (Homo sapiens)
REACT:R-HSA-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)
REACT:R-XTR-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Xenopus tropicalis)
RHEA:71745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + hexanedioate(out) => 2-oxoglutarate(out) + hexanedioate(in)
REACT:R-HSA-168860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane fusion (Homo sapiens)
RHEA:64270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	emodin + H(+) + H2O => emodin anthrone + O2
REACT:R-CFA-5685605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF7 binds SLAMF7 (Canis familiaris)
RHEA:69422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypoiodite => H2O2 + iodide
REACT:R-HSA-5626681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of transition zone proteins (Homo sapiens)
RHEA:72489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + phosphoenolpyruvate(out) => citrate(out) + phosphoenolpyruvate(in)
GO:0030412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formiminotetrahydrofolate cyclodeaminase activity
GO:0030412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formimidoyltetrahydrofolate cyclodeaminase activity
GO:0030412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)
GO:0030412	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)
REACT:R-MMU-6784319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,TYK2 phosphorylate JAK1,TYK2 (Mus musculus)
REACT:R-XTR-1296035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Xenopus tropicalis)
RHEA:58835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium transmembrane transporter activity, phosphorylative mechanism
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-translocating P-type ATPase activity
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Na(+)-exporting ATPase activity
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium exporting ATPase activity, phosphorylative mechanism
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Na+-exporting ATPase activity
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Na(+)-transporting ATPase activity
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-exporting ATPase activity, phosphorylative mechanism
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium transport ATPase activity
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type sodium transporter activity
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Na+-transporting ATPase activity
GO:0008554	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium-exporting ATPase activity
REACT:R-DRE-193052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione isomerizes to progesterone (Danio rerio)
RHEA:45935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-RNO-420123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like receptor 2 binds GLP2 (Rattus norvegicus)
REACT:R-DRE-2473594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP15 (Danio rerio)
RHEA:65577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate => an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP
REACT:R-BTA-5362427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds GPC5 (Bos taurus)
RHEA:47143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-5685366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y-SHC (Drosophila melanogaster)
RHEA:36506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA
REACT:R-MMU-8987096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)
GO:0033781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P450 46A1
GO:0033781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol 24-hydroxylase activity
GO:0033781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP46A1
GO:0033781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol 24-monooxygenase activity
GO:0033781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity
GO:0033781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP46
GO:0033781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol 24S-hydroxylase activity
REACT:R-CFA-205289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of KIT (Canis familiaris)
REACT:R-SSC-8850818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK9 binds KLK5 (Sus scrofa)
RHEA:30917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O
RHEA:28236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + H(+) + H2O => L-glutamate 5-semialdehyde
RHEA:66067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxohexanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate
RHEA:29433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + diphosphate => ATP + phosphate
RHEA:22861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + nicotinate beta-D-ribonucleotide => deamido-NAD(+) + diphosphate
RHEA:24640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosteryl 3-beta-D-glucoside + H2O = D-glucose + ergosterol
GO:0019534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toxin transmembrane transporter activity
GO:0050183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine 12-monooxygenase activity
GO:0050183	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oleate delta12-hydroxylase activity
GO:0050183	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oleate delta12-monooxygenase activity
GO:0050183	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)
GO:0050183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleate D12-hydroxylase activity
GO:0050183	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oleate Delta(12)-hydroxylase activity
GO:0050183	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ricinoleic acid synthase activity
RHEA:42915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-6797627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPG hydrolyses L-Asn to L-Asp (Mus musculus)
RHEA:71887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide
REACT:R-HSA-6806613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin tetramers bind to form unit length filaments (Homo sapiens)
RHEA:66007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] <=> Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M
RHEA:37391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
RHEA:35629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP => delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose
REACT:R-MMU-9700171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates PLCG1 (Mus musculus)
GO:0004173	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl-CoA:ecdysone palmitoyltransferase activity
GO:0004173	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acyl-CoA:ecdysone acyltransferase activity
GO:0004173	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:ecdysone acyltransferase activity
GO:0004173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone O-acyltransferase activity
REACT:R-BTA-445752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Bos taurus)
RHEA:64301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropylamine + pyruvate => 3-phenylpropanal + L-alanine
REACT:R-CFA-2168046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XII degradation by MMP12 (Canis familiaris)
RHEA:59251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA <=> (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA
REACT:R-SCE-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Saccharomyces cerevisiae)
REACT:R-CFA-5649711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 incises DNA strand 5' to the AP site (Canis familiaris)
REACT:R-GGA-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Gallus gallus)
REACT:R-SSC-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Sus scrofa)
RHEA:23987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + NADP(+) <=> 7-dehydrocholesterol + H(+) + NADPH
REACT:R-GGA-976810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to extracellular Factor H:C3b (Gallus gallus)
REACT:R-BTA-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Bos taurus)
RHEA:17678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O => 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)
RHEA:30208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylamine + 2 oxidized [amicyanin] => formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]
REACT:R-RNO-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Rattus norvegicus)
REACT:R-HSA-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Homo sapiens)
RHEA:49465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxybenzoate + H(+) => CO2 + resorcinol
REACT:R-HSA-9706977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6:KPNA2 binds KPNB1 (Homo sapiens)
REACT:R-MMU-8870332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Mus musculus)
REACT:R-DME-5691006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Drosophila melanogaster)
REACT:R-SSC-373061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR3, 4 and 5 bind CCL5 ligand (Sus scrofa)
RHEA:23958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-HSA-140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Homo sapiens)
REACT:R-HSA-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)
GO:0004611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate carboxykinase activity
GO:0004611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITP + oxaloacetate = CO2 + IDP + phosphoenolpyruvate
GO:0004611	skos:altLabel	"phosphoenolpyruvate carboxylase"
GO:0004611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEPCK activity
GO:0004611	skos:prefLabel	"phosphoenolpyruvate carboxykinase (GTP)"
GO:0004611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate carboxylase activity
GO:0004611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate
GO:0004611	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEP carboxykinase activity
GO:0004611	skos:altLabel	"phosphopyruvate carboxylase"
GO:0004611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoenolpyruvate carboxykinase (GTP)"
GO:0004611	skos:altLabel	"PEP carboxykinase"
GO:0004611	skos:altLabel	"phosphoenolpyruvate carboxykinase"
GO:0004611	skos:altLabel	"PEPCK"
REACT:R-DME-9033491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Drosophila melanogaster)
RHEA:11080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thymidylate 5'-phosphatase"
RHEA:11080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + H2O = phosphate + thymidine
RHEA:11080	skos:altLabel	"thymidylate 5'-nucleotidase"
RHEA:11080	skos:prefLabel	"thymidylate 5'-phosphatase"
RHEA:60558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(35) in tRNA(Tyr) => uridine(35) in tRNA(Tyr)
REACT:R-XTR-9718379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds chemical antagonists (Xenopus tropicalis)
REACT:R-RNO-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Rattus norvegicus)
REACT:R-RNO-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Rattus norvegicus)
REACT:R-HSA-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Homo sapiens)
REACT:R-HSA-5654157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR2 (Homo sapiens)
RHEA:12818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydrobiochanin A + NADP(+) => biochanin A + 2 H(+) + NADPH
GO:0005500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juvenile hormone binding
REACT:R-HSA-77312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Homo sapiens)
REACT:R-HSA-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Homo sapiens)
REACT:R-CFA-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)
REACT:R-CFA-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Canis familiaris)
RHEA:60520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine
RHEA:33942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine + NADH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NAD(+)
REACT:R-DDI-389986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Dictyostelium discoideum)
REACT:R-DME-3640844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 binds RibC-AXIN:TNKS complex (Drosophila melanogaster)
REACT:R-XTR-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Xenopus tropicalis)
REACT:R-CFA-3149539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)
REACT:R-HSA-1028816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Homo sapiens)
REACT:R-BTA-4420121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate PLCG1 (Bos taurus)
RHEA:27844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-aminobiphenyl-2,3-diol + NADP(+) => 9H-carbazole + H(+) + NADPH + O2
REACT:R-RNO-6786034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Rattus norvegicus)
REACT:R-DRE-8981926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK3 (Danio rerio)
REACT:R-MMU-8856189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF8 binds TNFRSF8 (Mus musculus)
REACT:R-RNO-183002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Rattus norvegicus)
RHEA:32323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:32323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-kaurene monooxygenase"
RHEA:32323	skos:prefLabel	"ent-kaurene monooxygenase"
RHEA:32323	skos:altLabel	"ent-kaurene oxidase"
REACT:R-MMU-5357757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)
REACT:R-GGA-433608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [endoplasmic reticulum] (Gallus gallus)
REACT:R-DRE-8849638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the SPINK5:KLK5 complex at low pH (Danio rerio)
REACT:R-RNO-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Rattus norvegicus)
RHEA:10038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + vanillin => 4-hydroxy-3-methoxy-benzenemethanol + O2
REACT:R-RNO-9689680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNG inhibitors (Rattus norvegicus)
REACT:R-DRE-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Danio rerio)
RHEA:52603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine + propanoyl-CoA <=> CoA + H(+) + N-propanoyl-L-methioninate
GO:0047595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity
GO:0047595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxynicotinic reductase activity
GO:0047595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-oxotetrahydronicotinate dehydrogenase activity
GO:0047595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-oxotetrahydro-nicotinate dehydrogenase activity
GO:0047595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HNA reductase activity
GO:0047595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate reductase activity
GO:0047595	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity
GO:0032408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MutSbeta complex binding
REACT:R-RNO-2395328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP1, LTBP3 bind TGF-Beta (Rattus norvegicus)
REACT:R-RNO-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Rattus norvegicus)
REACT:R-DRE-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Danio rerio)
RHEA:16965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = beta-myrcene + diphosphate
RHEA:16965	skos:prefLabel	"myrcene synthase"
RHEA:16965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"myrcene synthase"
REACT:R-XTR-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Xenopus tropicalis)
REACT:R-MMU-751039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (12/13) reassociates with G beta:gamma (Mus musculus)
REACT:R-CEL-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Caenorhabditis elegans)
RHEA:48942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 an L-alpha-amino acid => an L-aminoacyl-L-amino acid + H2O
GO:0030731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanidoacetate methyltransferase activity
GO:0030731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity
GO:0030731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate N-methyltransferase activity
GO:0030731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine-guanidinoacetic transmethylase activity
GO:0030731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GA methylpherase activity
GO:0030731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanidinoacetate transmethylase activity
GO:0030731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanidinoacetate methyltransferase activity
REACT:R-HSA-418846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of UNC5A (Homo sapiens)
REACT:R-HSA-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Homo sapiens)
REACT:R-GGA-5654605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS3 (Gallus gallus)
REACT:R-HSA-1482897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Homo sapiens)
REACT:R-HSA-9669868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nilotinib-resistant KIT mutants do not bind nilotinib (Homo sapiens)
REACT:R-HSA-8985201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCE1 binds RNASEL (Homo sapiens)
RHEA:71740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate(in) + 2-oxoglutarate(out) => 2-oxoadipate(out) + 2-oxoglutarate(in)
RHEA:34123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7-trioxododecanoyl-CoA = CoA + H(+) + olivetolate
RHEA:34123	skos:prefLabel	"olivetolic acid cyclase"
RHEA:34123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"olivetolic acid cyclase"
GO:0070402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced nicotinamide adenine dinucleotide phosphate binding
GO:0070402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH binding
GO:0070402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced NADP binding
GO:0070402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP (reduced) binding
RHEA:23507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + H2O <=> (R)-1-aminopropan-2-ol + adenosylcob(III)yrate
GO:0019010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-methionine:farnesoic acid O-methyltransferase activity
GO:0019010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesoic acid O-methyltransferase activity
REACT:R-GGA-5362441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Gallus gallus)
REACT:R-SSC-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Sus scrofa)
RHEA:30511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinone-8 + H(+) + NADPH = 2-demethylmenaquinol-8 + NADP(+)
REACT:R-RNO-6798044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTG2 binds CCR4-NOT complex (Rattus norvegicus)
RHEA:10871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA
REACT:R-DRE-419011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectins (Danio rerio)
REACT:R-RNO-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Rattus norvegicus)
REACT:R-HSA-4420052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)
RHEA:40465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O
RHEA:47218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:22339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + L-homocysteine <=> L-methionine + N,N-dimethylglycine
REACT:R-SSC-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Sus scrofa)
REACT:R-CEL-3928633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bPIX exchanges GTP for GDP on RAC, activating it (Caenorhabditis elegans)
RHEA:38528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)
REACT:R-SSC-5682967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 binds DNA DSBs (Sus scrofa)
RHEA:56577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine => globoside Gb4Cer + H(+) + UDP
REACT:R-SSC-9027321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Sus scrofa)
REACT:R-XTR-141367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylation of tBID by NMT1 (Xenopus tropicalis)
REACT:R-MMU-2032768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of WWTR1 (TAZ) to the nucleus (Mus musculus)
REACT:R-DME-1602399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLB1 (Drosophila melanogaster)
REACT:R-XTR-5686900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 recruits DCLRE1C to ATM (Xenopus tropicalis)
RHEA:63979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydropyriculariol <=> AH2 + pyriculariol
RHEA:61139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + quercetin + succinate
RHEA:15412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine
REACT:R-MMU-211874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2S1 4-hydroxylates atRA (Mus musculus)
RHEA:18771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate
REACT:R-CFA-8937744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-7Y-RUNX1 (Canis familiaris)
REACT:R-DME-5690517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT1 hydrolyses palmitoylated proteins (Drosophila melanogaster)
RHEA:21835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:24193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)
GO:0018642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophenol 4-monooxygenase activity
REACT:R-GGA-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Gallus gallus)
RHEA:44393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
GO:0015245	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peroxisomal fatty acyl transporter
GO:0015245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid transmembrane transporter activity
GO:0015245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acyl transporter activity
GO:0015245	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acid transporter activity
GO:0015245	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fatty-acyl group transporter activity
GO:0000298	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyphosphate depolymerase activity
GO:0000298	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	metaphosphatase activity
GO:0000298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polymetaphosphatase activity
GO:0000298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyphosphate polyphosphohydrolase activity
GO:0000298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endopolyphosphatase activity
GO:0000298	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyphosphatase activity
REACT:R-HSA-2530501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTA:FNTB transfers FARN to GNGT1 (Homo sapiens)
REACT:R-HSA-9698408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates active FLT3 (Homo sapiens)
RHEA:25753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-9718360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide agonists (Bos taurus)
REACT:R-GGA-202466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Bcl10 to CARMA1 (Gallus gallus)
REACT:R-MMU-2730843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LAT by p-SYK (Mus musculus)
GO:0015344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	siderophore uptake transmembrane transporter activity
GO:0015344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferrioxamine uptake transmembrane transporter activity
GO:0015344	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	siderophore-iron uptake transmembrane transporter activity
GO:0015344	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	siderochrome-iron (ferrioxamine) uptake transporter
RHEA:47352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hexanoate ester + H2O = an aliphatic alcohol + H(+) + hexanoate
REACT:R-DRE-190261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3c binds to FGF (Danio rerio)
REACT:R-GGA-5685011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR activation at DNA DSBs (Gallus gallus)
RHEA:40989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O => EDTA + 2 FMNH2 + 2 O2
REACT:R-GGA-6800299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGFAC cleaves pro-HGF to form HGF dimer (Gallus gallus)
RHEA:21609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoliquiritigenin + S-adenosyl-L-methionine => 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine
REACT:R-BTA-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Bos taurus)
REACT:R-DDI-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Dictyostelium discoideum)
REACT:R-HSA-2395768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPL hydrolyses TGs from mature CMs (Homo sapiens)
REACT:R-DME-9661799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)
REACT:R-SSC-6813740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDE1 hydrolyzes GroPIns (Sus scrofa)
REACT:R-RNO-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Rattus norvegicus)
REACT:R-GGA-5607753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD9 oligomerizes (Gallus gallus)
REACT:R-CFA-937311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)
REACT:R-DDI-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Dictyostelium discoideum)
REACT:R-RNO-8964280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Gq binds BTK (Rattus norvegicus)
RHEA:32511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)
RHEA:32511	skos:prefLabel	"monoterpene epsilon-lactone hydrolase"
RHEA:32511	skos:altLabel	"MLH"
RHEA:32511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monoterpene epsilon-lactone hydrolase"
REACT:R-GGA-9018814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 hydrolyzes GTP (Gallus gallus)
REACT:R-MMU-994137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Mus musculus)
RHEA:46786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:71196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Zn(2+)(out) => H(+)(in) + Zn(2+)(in)
REACT:R-BTA-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Bos taurus)
RHEA:26393	skos:altLabel	"carotenoid cleavage dioxygenase"
RHEA:26393	skos:prefLabel	"carotenoid 9,10-dioxygenase"
RHEA:26393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carotenoid 9,10-dioxygenase"
RHEA:26393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 O2 = 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
RHEA:26393	skos:altLabel	"carotenoid 9,10(9',10')-cleavage dioxygenase"
REACT:R-BTA-4719448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO3 (Bos taurus)
RHEA:14455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH => 4-(phosphooxy)-L-threonine + NAD(+)
REACT:R-DRE-804969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B1 hydrogenates E1 to EST17b (Danio rerio)
REACT:R-SSC-6811508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2-bound EP300 acetylates TP53 (Sus scrofa)
REACT:R-DRE-73815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
RHEA:62051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
RHEA:27897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-CMP + H2O <=> cytidine + phosphate
REACT:R-HSA-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Homo sapiens)
RHEA:41782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate
REACT:R-CFA-2424243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Canis familiaris)
REACT:R-HSA-9635461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtpA dephosphorylates GSK3A (Homo sapiens)
REACT:R-HSA-1855217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 transports from the ER lumen to the cytosol (Homo sapiens)
GO:0102050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-tyrosine synthetase activity
REACT:R-RNO-212706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipase C-gamma1 binds to the activated EGF receptor (Rattus norvegicus)
RHEA:36620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxydocosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine
REACT:R-BTA-5654605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS3 (Bos taurus)
RHEA:68760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine
REACT:R-GGA-349638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of SR-BI-bound spherical HDL (Gallus gallus)
REACT:R-CEL-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Caenorhabditis elegans)
REACT:R-DRE-111915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK4 autophosphorylates (Danio rerio)
RHEA:51153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a thiol + L-cysteinyl-[sulfatase] + O2 => 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide
REACT:R-BTA-5138441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A-FZD4 recruits DVL2 (Bos taurus)
REACT:R-DRE-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
RHEA:65418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP(out) + NAD(+)(in) => dGMP(in) + NAD(+)(out)
REACT:R-GGA-5618105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Gallus gallus)
REACT:R-HSA-4084982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Homo sapiens)
REACT:R-RNO-75146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)
REACT:R-XTR-141348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAO:FAD oxidises NASPM to PTCN (Xenopus tropicalis)
REACT:R-DRE-8938108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds cathepsin L (Danio rerio)
GO:0016493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-C chemokine receptor activity
REACT:R-BTA-192061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP46A1 24-hydroxylates CHOL (Bos taurus)
REACT:R-BTA-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Bos taurus)
RHEA:30464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate
REACT:R-DRE-201595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plakophilin-1 (Danio rerio)
RHEA:34740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine
RHEA:32232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADPHX + ATP => ADP + H(+) + NADPH + phosphate
GO:0102784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutein oxygenase activity
RHEA:14433	skos:altLabel	"transfer-RNA nucleotidyltransferase"
RHEA:14433	skos:altLabel	"transfer RNA adenylyltransferase"
RHEA:14433	skos:altLabel	"tRNA CCA-diphosphorylase"
RHEA:14433	skos:altLabel	"CCA-adding enzyme"
RHEA:14433	skos:altLabel	"tRNA cytidylyltransferase"
RHEA:14433	skos:altLabel	"tRNA adenylyl(cytidylyl)transferase"
RHEA:14433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate
RHEA:14433	skos:altLabel	"ribonucleic cytidylic cytidylic adenylic pyrophosphorylase"
RHEA:14433	skos:altLabel	"transfer ribonucleic adenylyl (cytidylyl) transferase"
RHEA:14433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CCA tRNA nucleotidyltransferase"
RHEA:14433	skos:altLabel	"tRNA-nucleotidyltransferase"
RHEA:14433	skos:prefLabel	"CCA tRNA nucleotidyltransferase"
REACT:R-CFA-844447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 senses MDP (Canis familiaris)
REACT:R-BTA-5632652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds CDON and PTCH (Bos taurus)
RHEA:35880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:50084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)
REACT:R-CFA-8875490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind ubiquitinated MET (Canis familiaris)
REACT:R-MMU-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Mus musculus)
REACT:R-GGA-212222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 recruits DNA methyltransferases (Gallus gallus)
GO:0043014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-tubulin binding
GO:0043014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha tubulin binding
RHEA:38344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + H2O => (20S)-ginsenoside Rg3 + D-glucose
RHEA:47292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5218815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds NCK (Bos taurus)
RHEA:47006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + phosphate => H2O + O-phospho-L-threonyl-[protein]
RHEA:23664	skos:altLabel	"2-oxoacid reductase"
RHEA:23664	skos:prefLabel	"2-oxo-acid reductase"
RHEA:23664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxo-acid reductase"
RHEA:23664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a (2R)-2-hydroxycarboxylate = a 2-oxocarboxylate + AH2
RHEA:23664	skos:altLabel	"HVOR"
RHEA:23664	skos:altLabel	"(2R)-hydroxycarboxylate-viologen-oxidoreductase"
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2',3'-cyclic nucleotide phosphohydrolase
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic 2',3'-nucleotide 2'-phosphodiesterase activity
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclic 2',3'-nucleotide phosphodiesterase
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonucleoside 2',3'-cyclic phosphate diesterase activity
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2',3 '-cyclic AMP phosphodiesterase activity
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2',3'-cyclic nucleoside monophosphate phosphodiesterase
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2':3'-cyclic phosphodiesterase activity
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic phosphodiesterase:3'-nucleotidase activity
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2',3'-cyclic AMP 2'-phosphohydrolase activity
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2',3'-cyclic nucleotidase activity
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
GO:0008663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity
RHEA:32561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + gamma-terpinene => (2E)-geranyl diphosphate
REACT:R-XTR-70859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Xenopus tropicalis)
RHEA:14504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-homocysteine <=> 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)
RHEA:36153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamyl acetate + CoA => (E)-cinnamyl alcohol + acetyl-CoA
REACT:R-XTR-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Xenopus tropicalis)
REACT:R-MMU-975903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Mus musculus)
REACT:R-CFA-445757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1 receptor antagonist protein binds Interleukin 1 receptors (Canis familiaris)
GO:0103100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity
REACT:R-DRE-9684068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD binds cardiac glycosides (Danio rerio)
RHEA:47464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA
REACT:R-HSA-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Homo sapiens)
REACT:R-DRE-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Danio rerio)
EC:4.2.2.24	skos:prefLabel	"rhamnogalacturonan exolyase"
EC:4.2.2.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnogalacturonan exolyase"
REACT:R-CEL-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
RHEA:65644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine
REACT:R-GGA-438005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKK4 phosphorylates JNK (Gallus gallus)
RHEA:60231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate
REACT:R-HSA-6787820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds CSF1R (Homo sapiens)
REACT:R-BTA-265645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Influx through Voltage-gated Calcium Channels (Bos taurus)
RHEA:68800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nigerose = alpha-D-glucose + D-glucose
RHEA:12370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-didehydro-D-gluconate + AH2 => 2-dehydro-D-gluconate + A
RHEA:62396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-pseudoephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
RHEA:62396	skos:prefLabel	"pseudoephedrine dehydrogenase"
RHEA:62396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudoephedrine dehydrogenase"
REACT:R-DRE-187035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-beta-NGF and mature beta-NGF are secreted (Danio rerio)
RHEA:40518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose 1-phosphate <=> (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate
REACT:R-DRE-1482546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)
RHEA:49517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 => an adenosine in mRNA + CO2 + formaldehyde + succinate
REACT:R-SSC-9686088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDMD (Sus scrofa)
RHEA:30354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + pyrrole-2-carboxylate <=> 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)
RHEA:47100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + taurine = CoA + H(+) + taurocholate
REACT:R-BTA-430073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Bos taurus)
REACT:R-BTA-8852019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET bound PI3K generates PIP3 (Bos taurus)
REACT:R-MMU-469659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A1 dehydrogenates TEST to DHTEST (Mus musculus)
REACT:R-CFA-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Canis familiaris)
RHEA:33955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIBOA + UDP-alpha-D-glucose = DIBOA beta-D-glucoside + H(+) + UDP
GO:0034915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexanoyl-CoA C-acetyltransferase activity
REACT:R-HSA-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Homo sapiens)
REACT:R-XTR-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Xenopus tropicalis)
RHEA:17158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + creatine => ADP + H(+) + N-phosphocreatine
REACT:R-RNO-6784323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Rattus norvegicus)
RHEA:55433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:39745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in)
REACT:R-XTR-9026777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)
REACT:R-MMU-2428930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Mus musculus)
REACT:R-DME-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-BTA-9033516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)
REACT:R-XTR-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Xenopus tropicalis)
REACT:R-HSA-8869549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter (Homo sapiens)
GO:0003949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity
GO:0003949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
GO:0003949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity
GO:0003949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity
GO:0003949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity
GO:0003949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity
GO:0003949	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity
RHEA:27454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide + L-tyrosine + NADP(+) => 3-iodo-L-tyrosine + NADPH
REACT:R-BTA-71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Bos taurus)
REACT:R-SSC-1504213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Sus scrofa)
REACT:R-BTA-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Bos taurus)
REACT:R-RNO-8956458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNLS:FAD oxidises dh-beta-NAD to NAD+ (Rattus norvegicus)
REACT:R-CEL-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Caenorhabditis elegans)
RHEA:42609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + (n+1) H(+)(in) + NADH => a plastoquinol + n H(+)(out) + NAD(+)
GO:0071164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA trimethylguanosine synthase activity
GO:0071164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	small nuclear RNA methyltransferase activity
GO:0071164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	snRNA methyltransferase activity
GO:0071164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cap hypermethylase activity
REACT:R-GGA-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Gallus gallus)
REACT:R-HSA-3301943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTK1 dimer transfers GS from GSH to CDNB (Homo sapiens)
REACT:R-RNO-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Rattus norvegicus)
RHEA:68544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate
RHEA:52939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O <=> (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]
REACT:R-HSA-450595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR:mRNA complex translocates from the nucleus to the cytosol (Homo sapiens)
RHEA:69612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kojibiose => beta-D-glucose + D-glucose
RHEA:59336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-all-trans-1,2-dihydro-neurosporene + A = AH2 + demethylspheroidene
REACT:R-HSA-3149440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of VPU to Golgi apparatus (Homo sapiens)
REACT:R-SSC-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Sus scrofa)
RHEA:71933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + 3 Na(+)(in) => fumarate(out) + 3 Na(+)(out)
REACT:R-BTA-9617996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Bos taurus)
REACT:R-SSC-76354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vinyl chloride is oxidized to 2-Chloroethylene oxide (Sus scrofa)
RHEA:59181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O => 2 AMP + H(+)
RHEA:24164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]
RHEA:24164	skos:altLabel	"methionine sulfoxide reductase B"
RHEA:24164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptide-methionine (R)-S-oxide reductase"
RHEA:24164	skos:altLabel	"methionine S-oxide reductase"
RHEA:24164	skos:altLabel	"methionine sulfoxide reductase"
RHEA:24164	skos:altLabel	"selenoprotein R"
RHEA:24164	skos:altLabel	"methionine S-oxide reductase (R-form oxidizing)"
RHEA:24164	skos:prefLabel	"peptide-methionine (R)-S-oxide reductase"
REACT:R-XTR-3321883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSL acetylates histone H4 (Xenopus tropicalis)
RHEA:45597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-HSA-9624120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK2 (Homo sapiens)
GO:0016868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular transferase activity, phosphotransferases
GO:0016868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphotransferases (phosphomutases)"
GO:0016868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphomutase activity
GO:0016868	skos:prefLabel	"Phosphotransferases (phosphomutases)"
GO:0016868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers
GO:0102841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity
REACT:R-HSA-375154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)
REACT:R-HSA-158982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Homo sapiens)
RHEA:67350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => apigenin 7-O-beta-D-glucoside + malonyl-CoA
RHEA:59464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octadecan-1-ol = H(+) + NADPH + octadecanal
REACT:R-CEL-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)
REACT:R-CFA-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Canis familiaris)
RHEA:64977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTP + 2 H2O => 8-oxo-dGMP + 2 H(+) + 2 phosphate
RHEA:67815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]
REACT:R-SSC-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Sus scrofa)
REACT:R-XTR-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Xenopus tropicalis)
REACT:R-XTR-1977958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with ERBB3 (Xenopus tropicalis)
REACT:R-DRE-2872498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Danio rerio)
REACT:R-CEL-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Caenorhabditis elegans)
RHEA:28889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-serine(out) => H(+)(in) + L-serine(in)
REACT:R-RNO-5668454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Rattus norvegicus)
RHEA:41288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetradecanoylsphing-4-enine => sphing-4-enine + tetradecanoate
REACT:R-DME-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Drosophila melanogaster)
REACT:R-DME-947535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Drosophila melanogaster)
RHEA:31395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + FAD + H(+) = all-trans-4,4'-diapophytofluene + FADH2
REACT:R-BTA-380508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NuMA to the centrosomes (Bos taurus)
GO:0005157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrophage colony-stimulating factor receptor binding
GO:0005157	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	macrophage colony-stimulating factor receptor ligand
GO:0005157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M-CSF receptor binding
GO:0005157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrophage colony stimulating factor receptor binding
REACT:R-HSA-422104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase octanoylates Proghrelin (Homo sapiens)
REACT:R-SSC-2213205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type XII and XIV collagens associate with type I and type II fibrils. (Sus scrofa)
REACT:R-GGA-751001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (i) reassociates with G beta:gamma (Gallus gallus)
RHEA:63164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tricosanoyl-taurine = taurine + tricosanoate
RHEA:60095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> 3-dehydro-4alpha-methylzymosterol + CO2 + NADH
REACT:R-GGA-9756180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)
REACT:R-MMU-6809015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Mus musculus)
REACT:R-MMU-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Mus musculus)
RHEA:49843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)
GO:0003920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-monophosphate oxidoreductase activity
GO:0003920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine-5'-phosphate:NADP+ oxidoreductase (aminating)
GO:0003920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)
GO:0003920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:GMP oxidoreductase (deaminating) activity
GO:0003920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity
GO:0003920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanylate reductase activity
GO:0003920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-monophosphate reductase activity
GO:0003920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP reductase activity
GO:0003920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine monophosphate reductase activity
GO:0003920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-phosphate reductase activity
REACT:R-GGA-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Gallus gallus)
RHEA:35525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-ethylsuccinimide + NADP(+) => H(+) + N-ethylmaleimide + NADPH
REACT:R-MMU-5340251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Mus musculus)
RHEA:11695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + NADPH <=> NADH + NADP(+)
REACT:R-SSC-1370500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR binds SCF beta-TrCP complex (Sus scrofa)
RHEA:57757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
REACT:R-BTA-1006143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C3b (Bos taurus)
REACT:R-GGA-8874979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD3 binds GOLGB1 (Gallus gallus)
RHEA:71937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate(in) + 2 Na(+)(in) => glycocholate(out) + 2 Na(+)(out)
RHEA:61665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + ATP => (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)
REACT:R-CFA-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
RHEA:57066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apionate + H(+) => D-apionolactone + H2O
REACT:R-DME-72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of mRNA at the 3'-end (Drosophila melanogaster)
RHEA:49616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-2-methylpropanal dehydrogenase"
RHEA:49616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanal + H2O + NAD(+) = 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH
RHEA:49616	skos:prefLabel	"2-hydroxy-2-methylpropanal dehydrogenase"
REACT:R-HSA-9008054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RAPL1 (Homo sapiens)
REACT:R-SSC-8964246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in G alpha (12)-BTK complex is activated (Sus scrofa)
REACT:R-DME-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Drosophila melanogaster)
RHEA:52706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + uracil => H2O + UMP
RHEA:21157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate + H2O => (R)-glycerate + phosphate
REACT:R-GGA-373148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate + CoASH + GTP <=> succinylCoA + GDP + Pi (Gallus gallus)
GO:0140857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H3-T45 specific)
GO:0140857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3T45 kinase activity
GO:0140857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone threonine kinase activity (H3-T45 specific)
GO:0140857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-threonine kinase activity (H3-T45 specific)
REACT:R-CFA-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Canis familiaris)
GO:0019964	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	interferon-gamma binding
GO:0019964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG binding
GO:0019964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II interferon binding
GO:0019964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN-gamma binding
REACT:R-GGA-9613570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Gallus gallus)
REACT:R-HSA-9615348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR2 (Homo sapiens)
GO:0047418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phthalyl-amide amidohydrolase activity
GO:0047418	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	o-phthalyl amidase activity
GO:0047418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phthalyl amidase activity
REACT:R-RNO-2066778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)
REACT:R-CFA-5578965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A binds AGO2:miRNA (Canis familiaris)
REACT:R-XTR-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)
RHEA:69390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + H(+) + phosphate => (S)-2-ureidoglycine + carbamoyl phosphate
REACT:R-RNO-450490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B/Akt phosphorylates BRF1 (Rattus norvegicus)
RHEA:38999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine
REACT:R-RNO-936897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)
REACT:R-GGA-8854209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A binds JFC1 (Gallus gallus)
REACT:R-CFA-6809015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Canis familiaris)
REACT:R-CEL-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Caenorhabditis elegans)
RHEA:65463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hexan-1-ol <=> CoA + hexyl acetate
RHEA:58823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonate + Na(+)(in) <=> acetate + CO2 + Na(+)(out)
REACT:R-SSC-917987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFRC dimer binds 2xholoTF (Sus scrofa)
RHEA:45363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(11Z-eicosenoyl)-sphinganine <=> (11Z)-eicosenoate + sphinganine
RHEA:35239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracycline(in) = tetracycline(out)
GO:0004609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylserine decarboxylase activity
GO:0004609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidyl-L-serine carboxy-lyase activity
GO:0004609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)
GO:0004609	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PS decarboxylase activity
REACT:R-BTA-741411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates NEMO (Bos taurus)
RHEA:19050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysine + GTP => (5R)-5-phosphooxy-L-lysine + GDP + H(+)
RHEA:15815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + N-acetylimidazole => 1H-imidazole + acetyl-CoA
REACT:R-DRE-5688834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds VCP (Danio rerio)
GO:0099101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein gated potassium channel activity
REACT:R-DRE-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Danio rerio)
RHEA:44688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + H2O = a fatty acid + glycerol + H(+)
RHEA:54053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => diphosphate + tau-cadinol
REACT:R-CFA-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Canis familiaris)
RHEA:50204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate
REACT:R-MMU-429529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin binding to GP1b:IX:V (Mus musculus)
REACT:R-HSA-445064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by VAV2 (Homo sapiens)
RHEA:46977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2
REACT:R-RNO-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Rattus norvegicus)
RHEA:52231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O
RHEA:18592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutamine synthetase]-L-tyrosine + ATP <=> [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate
REACT:R-DRE-201637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plectin-1 (Danio rerio)
REACT:R-RNO-451418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates IRAK1 (Rattus norvegicus)
RHEA:35027	skos:altLabel	"tungstate-importing ATPase"
RHEA:35027	skos:altLabel	"tungstate transporter"
RHEA:35027	skos:altLabel	"tungstate-specific ABC transporter"
RHEA:35027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type tungstate transporter"
RHEA:35027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + tungstate(in) = ADP + H(+) + phosphate + tungstate(out)
RHEA:35027	skos:prefLabel	"ABC-type tungstate transporter"
REACT:R-CFA-8851298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR143 binds L-Dopa (Canis familiaris)
RHEA:45092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octanoylsphing-4-enine = octanoate + sphing-4-enine
RHEA:55194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methyldodecanoyl-CoA + O2
REACT:R-DRE-2485148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Danio rerio)
RHEA:34096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyspermidine + H(+) => CO2 + spermidine
RHEA:18454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O => [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate
RHEA:40299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:40299	skos:prefLabel	"6-deoxyerythronolide B hydroxylase"
RHEA:40299	skos:altLabel	"DEB hydroxylase"
RHEA:40299	skos:altLabel	"CYP107A1"
RHEA:40299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-deoxyerythronolide B hydroxylase"
REACT:R-HSA-158313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XII -> factor XIIa (Homo sapiens)
RHEA:28197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH
RHEA:40322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O2
REACT:R-CFA-9029580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Canis familiaris)
REACT:R-CFA-9674131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)
REACT:R-DDI-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Dictyostelium discoideum)
RHEA:38883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
RHEA:34374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-acetamide <=> (indol-3-yl)acetate + NH4(+)
RHEA:57800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dinitrotoluene + NADH + O2 = 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite
RHEA:26207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol + H2O + NADP(+) => 4-nitrophenol + H(+) + NADPH + O2
GO:0019982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-7 binding
GO:0019982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-7 binding
GO:0043237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laminin-1 binding
GO:0043237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laminin-111 binding
REACT:R-DME-444773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-TM7 receptors bind chondroitin sulphate (Drosophila melanogaster)
REACT:R-SPO-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Schizosaccharomyces pombe)
RHEA:63118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate => peroxynitrite
RHEA:58075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4,5-didehydrojasmonate + H(+) + NADPH <=> a jasmonate + NADP(+)
RHEA:42908	skos:prefLabel	"23S rRNA (uracil(1939)-C(5))-methyltransferase"
RHEA:42908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(1939) in 23S rRNA = 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (uracil(1939)-C(5))-methyltransferase"
RHEA:42908	skos:altLabel	"RNA uridine methyltransferase A"
REACT:R-DRE-164832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase synthesizes ATP (Danio rerio)
REACT:R-HSA-6791348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates APAF1 gene expression (Homo sapiens)
RHEA:15814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1H-imidazole + acetyl-CoA => CoA + N-acetylimidazole
REACT:R-DDI-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Dictyostelium discoideum)
REACT:R-XTR-5671772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T38-PPP1R14A binds MLCP (Xenopus tropicalis)
REACT:R-CEL-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Caenorhabditis elegans)
GO:0000269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toxin export channel activity
REACT:R-CFA-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Canis familiaris)
REACT:R-HSA-2731147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-4 binds PI(4,5)P2 (Homo sapiens)
REACT:R-SSC-6798474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Zn2+ (Sus scrofa)
GO:0008457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
GO:0008457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity
GO:0008457	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase
GO:0008457	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	poly-N-acetyllactosamine extension enzyme activity
REACT:R-DRE-8948224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)
RHEA:61122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase] => kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:68754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein] => alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]
REACT:R-GGA-751027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Gallus gallus)
REACT:R-HSA-2976726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 coactivator complex binds HES5 promoter (Homo sapiens)
RHEA:61964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:11040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
RHEA:11040	skos:prefLabel	"imidazoleglycerol-phosphate dehydratase"
RHEA:11040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"imidazoleglycerol-phosphate dehydratase"
RHEA:35729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycerol 3-phosphate + CoA => dodecanoyl-CoA + sn-glycerol 3-phosphate
REACT:R-CFA-5685341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex stabilizes RAD51 filament (Canis familiaris)
RHEA:53604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycerol + phosphate
REACT:R-GGA-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Gallus gallus)
REACT:R-DME-8937191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Drosophila melanogaster)
REACT:R-CFA-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Canis familiaris)
REACT:R-XTR-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Xenopus tropicalis)
REACT:R-BTA-109470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Bos taurus)
RHEA:34771	skos:altLabel	"3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)"
RHEA:34771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)"
RHEA:34771	skos:altLabel	"sterol 4alpha-carboxylic decarboxylase"
RHEA:34771	skos:altLabel	"3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)"
RHEA:34771	skos:altLabel	"sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)"
RHEA:34771	skos:prefLabel	"3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)"
RHEA:34771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH
RHEA:34771	skos:altLabel	"3beta-hydroxy-4beta-methylcholestenoate dehydrogenase"
RHEA:14855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-CoA + chloride + H(+) => 4-chlorobenzoyl-CoA + H2O
REACT:R-XTR-6805507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 binds AVEN (Xenopus tropicalis)
RHEA:15618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(3+) + Fe(II)-[cytochrome c] => Fe(2+) + Fe(III)-[cytochrome c]
REACT:R-CEL-8848005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 promotes PTK6 autophosphorylation (Caenorhabditis elegans)
RHEA:68424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 = (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
REACT:R-HSA-6782895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYW1:FMN:4Fe-4S  transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)
GO:0102955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity
REACT:R-HSA-5358340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoproteolytic cleavage of Hh precursors (Homo sapiens)
RHEA:31770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
RHEA:57305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP => glycolate + GMP + H(+)
REACT:R-HSA-9028730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FRS2 (Homo sapiens)
GO:0140592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R8 methyltransferase activity
GO:0140592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R8 arginine methyltransferase activity
GO:0140592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity (H3-R8 specific)
GO:0140592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R8 arginine methylase activity
GO:0140592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3R8 methyltransferase activity
REACT:R-BTA-71335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Bos taurus)
RHEA:12677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + Latia luciferin + 2 O2 = A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin
RHEA:12677	skos:prefLabel	"Latia-luciferin monooxygenase (demethylating)"
RHEA:12677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Latia-luciferin monooxygenase (demethylating)"
REACT:R-RNO-8852874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 binds C3d, C3dg, iC3b (Rattus norvegicus)
RHEA:19090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-1 + S-adenosyl-L-homocysteine
REACT:R-HSA-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)
REACT:R-CFA-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)
REACT:R-XTR-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Xenopus tropicalis)
RHEA:29765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate => ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)
RHEA:55581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine => AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate
RHEA:35596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + O2 => 2 H(+) + maleylacetate
REACT:R-DRE-6804425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F2 (Danio rerio)
GO:2001077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1->3,1->4-beta-glucan binding
GO:2001077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1,3),(1,4)-beta-glucan binding
GO:2001077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-(1,3),(1,4)-glucan binding
GO:2001077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-(1->3),(1->4)-glucan binding
GO:2001077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,3-1,4-glucan binding
GO:2001077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1->3,1->4-glucan binding
GO:2001077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1->3),(1->4)-beta-glucan binding
GO:0035923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid binding
GO:0035923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flurbiprofen binding
RHEA:57161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate
GO:0033265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline binding
RHEA:31647	skos:altLabel	"unsaturated glucuronyl hydrolase"
RHEA:31647	skos:prefLabel	"unsaturated chondroitin disaccharide hydrolase"
RHEA:31647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"unsaturated chondroitin disaccharide hydrolase"
RHEA:31647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate
REACT:R-RNO-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Rattus norvegicus)
RHEA:36291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine
REACT:R-SCE-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Saccharomyces cerevisiae)
RHEA:29267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out)
REACT:R-CFA-9013024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors at the plasma membrane (Canis familiaris)
REACT:R-GGA-433955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)
REACT:R-CEL-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)
RHEA:45598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-400682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Rac1 interacts with Plexin-B1:Sema4D (Homo sapiens)
REACT:R-GGA-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Gallus gallus)
RHEA:57928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipid II isoglutaminyl synthase (glutamine-hydrolyzing)"
RHEA:57928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate
RHEA:57928	skos:prefLabel	"lipid II isoglutaminyl synthase (glutamine-hydrolyzing)"
REACT:R-HSA-9031610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S133 CREB1, MEF2D and SRF  bind the ARC gene (Homo sapiens)
RHEA:34877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+)
RHEA:35586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate <=> D-glyceraldehyde + pyruvate
REACT:R-SSC-9020610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Sus scrofa)
RHEA:44021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + octadecanal => 2 H(+) + NADH + octadecanoate
RHEA:43682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA
REACT:R-BTA-5638007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 activates the GTPase activity of ARL3 (Bos taurus)
RHEA:22984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + oxamate = N-carbamoyl-2-oxoglycine + phosphate
RHEA:22984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxamate carbamoyltransferase"
RHEA:22984	skos:prefLabel	"oxamate carbamoyltransferase"
RHEA:22984	skos:altLabel	"oxamic transcarbamylase"
REACT:R-DRE-110011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Grb10 to the insulin receptor (Danio rerio)
REACT:R-RNO-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Rattus norvegicus)
REACT:R-XTR-5687284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMBT1 binds SFTPD 12mer, SFTPAs (Xenopus tropicalis)
REACT:R-CFA-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Canis familiaris)
REACT:R-XTR-909719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STAT2 to p-IFNAR1 (Xenopus tropicalis)
REACT:R-HSA-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Homo sapiens)
RHEA:35028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + tungstate(in) => ADP + H(+) + phosphate + tungstate(out)
REACT:R-MMU-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Mus musculus)
RHEA:62922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol
REACT:R-MMU-4341072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RARA with SUMO2 (Mus musculus)
REACT:R-RNO-8943780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)
REACT:R-RNO-9668904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18 complex (Rattus norvegicus)
REACT:R-RNO-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Rattus norvegicus)
REACT:R-HSA-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Homo sapiens)
REACT:R-HSA-2768993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants bind JAG2 (Homo sapiens)
RHEA:63353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:66017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + H2O2 => H2O + hypobromite
GO:0097493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural molecule activity conferring elasticity
REACT:R-MMU-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Mus musculus)
RHEA:33047	skos:altLabel	"P450camr"
RHEA:33047	skos:prefLabel	"(+)-camphor 6-endo-hydroxylase"
RHEA:33047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-camphor 6-endo-hydroxylase"
RHEA:33047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]
REACT:R-BTA-8851679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR183 binds 7alpha,25-dihydroxycholesterol (Bos taurus)
REACT:R-DRE-2022379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Danio rerio)
RHEA:17973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
GO:0047128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-reticuline:NADP+ oxidoreductase activity
GO:0047128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-dehydroreticulinium ion reductase activity
GO:0047128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dehydroreticulinium reductase (NADPH) activity
REACT:R-SSC-5674132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Sus scrofa)
RHEA:38171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA
RHEA:37036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminopentanoate + NAD(+) => 2-oxopentanoate + H(+) + NADH + NH4(+)
REACT:R-RNO-4720432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Rattus norvegicus)
RHEA:59350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltobionate + H(+) => D-maltobiono-1,5-lactone + H2O
REACT:R-HSA-380222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)
REACT:R-MMU-444691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prokineticin receptors bind prokineticin (Mus musculus)
REACT:R-MMU-8948832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 polyubiquitinates PARylated PTEN (Mus musculus)
RHEA:70047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + L-kynurenine = H2O + kynurenate + L-2-aminoadipate
REACT:R-DDI-481007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet alpha granule contents (Dictyostelium discoideum)
RHEA:55319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + hydrogen sulfide + 3 NAD(+) <=> 4 H(+) + 3 NADH + sulfite
REACT:R-RNO-114548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Rattus norvegicus)
REACT:R-SSC-5686072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-3Y-SHC1 dissociates from IGF1R (Sus scrofa)
REACT:R-RNO-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Rattus norvegicus)
RHEA:38688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine(in) + ATP + H2O => (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate
RHEA:34749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine 1-phosphate + ADP + H(+) => 15-methylhexadecasphinganine + ATP
REACT:R-BTA-2395784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent CMs transform into mature CMs (Bos taurus)
REACT:R-PFA-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Plasmodium falciparum)
REACT:R-DME-176474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Drosophila melanogaster)
GO:0016723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
GO:0016723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor
GO:0016723	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, reducing metal ions, NAD or NADP as acceptor
RHEA:71126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + ATP + H(+) + 2 malonyl-CoA <=> AMP + 2 CO2 + 2 CoA + diphosphate + hispidin
RHEA:56692	skos:prefLabel	"tyrosine isonitrile desaturase/decarboxylase"
RHEA:56692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate
RHEA:56692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine isonitrile desaturase/decarboxylase"
RHEA:54965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + phosphate => hexadecanoyl phosphate + holo-[ACP]
RHEA:25687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) => L-cysteinyl-tRNA(Cys) + phosphate
REACT:R-MMU-8851804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET recruits GRB2-1:SOS1 (Mus musculus)
REACT:R-HSA-453337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP (Homo sapiens)
EC:1.3.1.37	skos:prefLabel	"cis-2-enoyl-CoA reductase (NADPH)"
EC:1.3.1.37	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-2-enoyl-CoA reductase (NADPH)"
GO:0033042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	umami taste receptor activity
RHEA:34510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate <=> N,N-diacetyllegionaminate + phosphate
REACT:R-SSC-2203516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-1-Microglobulin is cleaved (Sus scrofa)
REACT:R-GGA-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Gallus gallus)
REACT:R-DRE-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Danio rerio)
REACT:R-SSC-70679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 oxidises L-GluSS to Glu (Sus scrofa)
REACT:R-RNO-2028589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Rattus norvegicus)
REACT:R-SSC-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Sus scrofa)
EC:3.4.17.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxypeptidase E"
EC:3.4.17.10	skos:altLabel	"carboxypeptidase H"
EC:3.4.17.10	skos:altLabel	"enkephalin convertase"
EC:3.4.17.10	skos:prefLabel	"carboxypeptidase E"
RHEA:70628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-HSA-73596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => dUMP + NH4+ (Homo sapiens)
GO:0043795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde oxidoreductase activity
RHEA:60220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate
RHEA:58923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (+)-medicarpin + H2O
GO:0019779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Atg8 activating enzyme activity
GO:0019779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APG7
GO:0019779	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APG8 activating enzyme activity
REACT:R-BTA-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Bos taurus)
REACT:R-HSA-5649657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 recognizes and binds FapyG-dsDNA (Homo sapiens)
RHEA:22777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O2 + 2 Mn(2+) => 2 H2O + 2 Mn(3+)
GO:0032181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dinucleotide repeat insertion binding
REACT:R-DRE-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Danio rerio)
RHEA:39099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanedioyl-CoA + CoA = acetyl-CoA + octanedioyl-CoA
REACT:R-DDI-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Dictyostelium discoideum)
REACT:R-BTA-353125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteosome degrades ODC holoenzyme complex (Bos taurus)
REACT:R-HSA-1461995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-defensin alpha 5 is stored in Paneth cell granules (Homo sapiens)
RHEA:67367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-threonyl-L-serine <=> L-serine + L-threonine
REACT:R-SSC-139898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 activates BID by cleavage (Sus scrofa)
RHEA:37139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-8869580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEK binds TFAP2A homodimers (Homo sapiens)
REACT:R-CEL-5692283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)
RHEA:65554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + lactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O
RHEA:44257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:63014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ilicicolinate B => (2E,6E)-farnesyl diphosphate + orsellinate
REACT:R-GGA-8876283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Gallus gallus)
EC:2.6.1.52	skos:prefLabel	"phosphoserine transaminase"
EC:2.6.1.52	skos:altLabel	"L-phosphoserine aminotransferase"
EC:2.6.1.52	skos:altLabel	"phosphohydroxypyruvic--glutamic transaminase"
EC:2.6.1.52	skos:altLabel	"3PHP transaminase"
EC:2.6.1.52	skos:altLabel	"PSAT"
EC:2.6.1.52	skos:altLabel	"hydroxypyruvic phosphate--glutamic transaminase"
EC:2.6.1.52	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoserine transaminase"
EC:2.6.1.52	skos:altLabel	"3-phosphoserine aminotransferase"
EC:2.6.1.52	skos:altLabel	"phosphohydroxypyruvate transaminase"
EC:2.6.1.52	skos:altLabel	"phosphoserine aminotransferase"
RHEA:10722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione => 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O
GO:0016217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-ethylammeline chlorohydrolase activity
REACT:R-SSC-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Sus scrofa)
RHEA:63262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxate + NAD(+) => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH
REACT:R-DME-3322434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP dissociates from ub-TLE (Drosophila melanogaster)
REACT:R-BTA-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Bos taurus)
RHEA:12145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-rutinoside + UDP-alpha-D-glucose => cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP
RHEA:70210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-4E,14Z-dienine-1-phosphate(in) <=> sphinga-4E,14Z-dienine-1-phosphate(out)
REACT:R-SPO-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Schizosaccharomyces pombe)
GO:0103102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity
REACT:R-SSC-392295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma recruits PI3K gamma (Sus scrofa)
REACT:R-MMU-391378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follicle-stimulating hormone receptor can bind FSH (Mus musculus)
RHEA:26388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal
GO:0008906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine kinase (phosphorylating)
GO:0008906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:inosine 5'-phosphotransferase activity
GO:0008906	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine-guanosine kinase activity
GO:0008906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine kinase activity
REACT:R-CFA-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Canis familiaris)
RHEA:44067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + octan-1-ol <=> CoA + octyl hexadecanoyl
REACT:R-PFA-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Plasmodium falciparum)
REACT:R-CFA-114548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Canis familiaris)
REACT:R-CFA-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Canis familiaris)
REACT:R-BTA-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Bos taurus)
REACT:R-CFA-5693742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH hydrolyses AEA to AA and ETA (Canis familiaris)
REACT:R-DRE-3225851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin and activate MAP3K5 (Danio rerio)
REACT:R-DRE-8867240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPCAM binds itself to form homotypic cell adhesion (Danio rerio)
REACT:R-MMU-1222376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide from oxygen (Mus musculus)
REACT:R-BTA-9023617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrylcholinesterase hydrolyzes acyl Ghrelin (Bos taurus)
REACT:R-HSA-8878243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HES1 gene transcription is inhibited by RUNX3 (Homo sapiens)
REACT:R-DRE-2046265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the keratan chain (Danio rerio)
RHEA:15363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl D-xylosyl phosphate + UDP => a dolichyl phosphate + UDP-alpha-D-xylose
RHEA:62440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pectin monosaccharide-lyase"
RHEA:62440	skos:altLabel	"exo-pectin lyase"
RHEA:62440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl methyl ester](n) = 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)
RHEA:62440	skos:prefLabel	"pectin monosaccharide-lyase"
RHEA:69558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(in) + H(+)(in) => D-glucose(out) + H(+)(out)
REACT:R-DRE-9625813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P binds S1PR3 in response to E2 stimulation (Danio rerio)
REACT:R-SPO-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Schizosaccharomyces pombe)
RHEA:20658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorophenylacetonitrile + 2 H2O => 4-chlorophenylacetate + NH4(+)
REACT:R-DDI-191983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)
REACT:R-CFA-391378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follicle-stimulating hormone receptor can bind FSH (Canis familiaris)
REACT:R-SSC-163090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation Of The Telomeric Chromosome End (Sus scrofa)
REACT:R-CEL-1296035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Caenorhabditis elegans)
REACT:R-CFA-5635861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH binds GLI1 (Canis familiaris)
RHEA:41914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + NADP(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADPH
RHEA:71982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene A
RHEA:72776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-carboxymellein + ATP + L-phenylalanine => ADP + H(+) + ochratoxin B + phosphate
REACT:R-DME-432427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP1 dephosphorylates phosphorylated TIM (Drosophila melanogaster)
RHEA:47090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)
RHEA:71104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) + S-methylmercury-L-cysteine(out) => L-methionine(out) + S-methylmercury-L-cysteine(in)
REACT:R-BTA-8983878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Bos taurus)
REACT:R-SSC-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Sus scrofa)
GO:0009374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin binding
GO:0009374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin H binding
GO:0009374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B7 binding
REACT:R-RNO-9020261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Rattus norvegicus)
REACT:R-CFA-5672083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KTN1 binds Kinesin-1 (Canis familiaris)
REACT:R-XTR-1855169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)
REACT:R-HSA-9713837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Psoralens in combination with UV generate DNA interstrand crosslinks (Homo sapiens)
REACT:R-CFA-8847968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN binds FRK (Canis familiaris)
RHEA:65024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) = dehydrocholate + H(+) + NADPH
REACT:R-HSA-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Homo sapiens)
REACT:R-XTR-9033516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Xenopus tropicalis)
RHEA:52284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8865098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to UBA6 in the cytosol (Homo sapiens)
REACT:R-GGA-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Gallus gallus)
REACT:R-RNO-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Rattus norvegicus)
REACT:R-DRE-428127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Danio rerio)
RHEA:42186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3beta,17beta-diol + NAD(+)
REACT:R-DME-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Drosophila melanogaster)
RHEA:49940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2
REACT:R-DME-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Drosophila melanogaster)
RHEA:61817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16,17-didehydropregnenolone + UDP-alpha-D-glucose => 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP
RHEA:38563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H(+)
RHEA:23405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate => diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
RHEA:13890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H2O => AMP + FMN + 2 H(+)
REACT:R-CFA-432295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI binds Fyn and Lyn (Canis familiaris)
REACT:R-HSA-936462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 mediated IRF3 degradation (Homo sapiens)
REACT:R-HSA-74726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of insulin from insulin receptor (Homo sapiens)
REACT:R-RNO-9733973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts bind FABP6 (Rattus norvegicus)
REACT:R-HSA-2160492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4I1:FAD oxidises L-Phe to kPPV (Homo sapiens)
REACT:R-GGA-9604328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates NOTCH4 (Gallus gallus)
REACT:R-SCE-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Saccharomyces cerevisiae)
REACT:R-CEL-445064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by VAV2 (Caenorhabditis elegans)
REACT:R-HSA-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)
GO:0050571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AF reductase activity
GO:0050571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose reductase activity
GO:0050571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity
RHEA:70150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:17560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + malonyl-CoA <=> CoA + N-malonylanthranilate
REACT:R-MMU-74715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of insulin receptor (Mus musculus)
RHEA:13979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + pyruvate => D-serine
RHEA:62656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate = 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate
RHEA:34801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5,6-didehydrosuberyl-CoA + CoA => 2,3-didehydroadipoyl-CoA + acetyl-CoA
GO:0034061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic acid polymerase activity
GO:0034061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase activity
GO:0034061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA nucleotidyltransferase activity
GO:0034061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic polymerase activity
GO:0034061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxynucleate polymerase activity
GO:0034061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleate nucleotidyltransferase activity
RHEA:64001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine
RHEA:39739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydodecanoate + H(+) + NADPH + O2 = 3,12-dihydroxydodecanoate + H2O + NADP(+)
RHEA:17053	skos:altLabel	"dihydroxyacetone transferase"
RHEA:17053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate
RHEA:17053	skos:altLabel	"glycerone transferase"
RHEA:17053	skos:prefLabel	"transaldolase"
RHEA:17053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"transaldolase"
REACT:R-HSA-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Homo sapiens)
REACT:R-BTA-211988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Bos taurus)
RHEA:26342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-selenocysteine + S-methyl-L-methionine => H(+) + L-methionine + Se-methyl-L-selenocysteine
RHEA:17372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhizin + H2O <=> 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate
RHEA:10438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA
RHEA:45031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-SCE-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Saccharomyces cerevisiae)
REACT:R-RNO-209944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D binds GC (Rattus norvegicus)
GO:0061662	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0061662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISG15 ligase activity
REACT:R-RNO-389352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Vav1 to CD28 (Rattus norvegicus)
REACT:R-GGA-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Gallus gallus)
REACT:R-CFA-420595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-2:Nectin 3 trans heterodimer interaction (Canis familiaris)
REACT:R-MMU-9603991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Mus musculus)
REACT:R-RNO-2428930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Rattus norvegicus)
RHEA:32758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + 2-oxoglutarate + O2 <=> apigenin + CO2 + H(+) + H2O + succinate
REACT:R-HSA-9021357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCI phosphorylates ELF3 (Homo sapiens)
GO:0015170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanediol transmembrane transporter activity
REACT:R-BTA-3215426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Bos taurus)
REACT:R-XTR-8953418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 complex binds E2F6.com-1 core (Xenopus tropicalis)
RHEA:60431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-L-aspartate + H2O <=> (indol-3-yl)acetate + L-aspartate
REACT:R-BTA-2160915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor-mediated uptake of HA (Bos taurus)
REACT:R-CEL-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Caenorhabditis elegans)
REACT:R-HSA-874079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIM2 oligomerizes (Homo sapiens)
REACT:R-SSC-382055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb7 binds to the active PDGF receptor (Sus scrofa)
REACT:R-DDI-6810474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Dictyostelium discoideum)
REACT:R-CFA-3244643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds cyclic GMP-AMP (Canis familiaris)
REACT:R-DRE-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Danio rerio)
RHEA:63940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine
GO:0050436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microfibril binding
RHEA:54352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:53363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(47) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(47) in tRNA
GO:0140223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	general transcription factor activity
GO:0140223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTF activity
GO:0140223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	general transcription initiation factor activity
GO:0140223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	basal transcription factor activity
REACT:R-CFA-8852552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1R autophosphorylates (Canis familiaris)
REACT:R-DRE-3928601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 and PIP2 bind WASL, activating it (Danio rerio)
RHEA:30738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 4-phosphate + H2O <=> myo-inositol + phosphate
REACT:R-HSA-507749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates PYR to form L-Ala (Homo sapiens)
REACT:R-BTA-5694494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)
RHEA:42053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol + NAD(+) => 9-cis-retinal + H(+) + NADH
REACT:R-HSA-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Homo sapiens)
RHEA:16908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine
REACT:R-RNO-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Rattus norvegicus)
REACT:R-RNO-417820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 receptor can bind to LPA (Rattus norvegicus)
REACT:R-XTR-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Xenopus tropicalis)
REACT:R-SSC-5672304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Sus scrofa)
RHEA:35324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH
RHEA:53146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:58278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic hexaadenylate + 6 diphosphate => 6 ATP
REACT:R-HSA-74730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin degradation (Homo sapiens)
REACT:R-BTA-420243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHRH receptor binds GHRH (Bos taurus)
REACT:R-HSA-392212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
REACT:R-DRE-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Danio rerio)
RHEA:44531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)
REACT:R-BTA-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Bos taurus)
RHEA:66462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14betaH-scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O
REACT:R-BTA-937337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Bos taurus)
REACT:R-CFA-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Canis familiaris)
REACT:R-HSA-422320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterotrimeric G(s) complex dissociates (Homo sapiens)
RHEA:60101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin + UDP-alpha-D-glucose => cyanidin 3-O-beta-D-glucoside + H(+) + UDP
GO:0018718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-phenanthrene glycosyltransferase activity
GO:0097697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA 5-carboxymethoxyuridine methyltransferase activity
REACT:R-MMU-5685011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR activation at DNA DSBs (Mus musculus)
REACT:R-CEL-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Caenorhabditis elegans)
REACT:R-GGA-8938815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 polyubiquitinates RRAGA (Gallus gallus)
REACT:R-XTR-914018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Xenopus tropicalis)
REACT:R-SSC-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Sus scrofa)
REACT:R-HSA-114440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)
REACT:R-GGA-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Gallus gallus)
REACT:R-HSA-156526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)
REACT:R-DRE-433099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS2 co-transports sulphate and two sodium ions (Danio rerio)
REACT:R-DME-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Drosophila melanogaster)
RHEA:65780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:29630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltohexaose + beta-maltose <=> alpha-maltoheptaose + beta-D-glucose
RHEA:12408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + NAD(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)
REACT:R-BTA-5624953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL13B binds INPP5E (Bos taurus)
RHEA:46677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) => (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH
RHEA:27489	skos:altLabel	"phosphoheptose isomerase"
RHEA:27489	skos:prefLabel	"D-sedoheptulose-7-phosphate isomerase"
RHEA:27489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-sedoheptulose-7-phosphate isomerase"
RHEA:27489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate
RHEA:27489	skos:altLabel	"sedoheptulose-7-phosphate isomerase"
REACT:R-XTR-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Xenopus tropicalis)
RHEA:28603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:20684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-cis-zeatin + UDP
RHEA:45025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADPH + O2 => 7-dehydrocholesterol + 2 H2O + NADP(+)
RHEA:29767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate
REACT:R-RNO-170026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protons are translocated from the intermembrane space to the matrix (Rattus norvegicus)
GO:0031714	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	C5a anaphylatoxin chemotactic receptor ligand
GO:0031714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5a anaphylatoxin chemotactic receptor binding
RHEA:59338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + demethylspheroidene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + A
REACT:R-GGA-5682858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate H2AFX (Gallus gallus)
RHEA:37920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
REACT:R-RNO-114264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAX to the mitochondria (Rattus norvegicus)
REACT:R-SSC-419002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Sus scrofa)
REACT:R-XTR-2172123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SIGLEC14/15/16 and DAP12 (Xenopus tropicalis)
RHEA:44857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-octadecenoyl-(R)-carnitine
EC:3.1.1.103	skos:prefLabel	"teichoic acid D-alanine hydrolase"
EC:3.1.1.103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"teichoic acid D-alanine hydrolase"
REACT:R-HSA-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Homo sapiens)
REACT:R-BTA-6805730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD9 methylates TP53 (Bos taurus)
REACT:R-MMU-8865667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPA hydrolyses sterol esters to sterols and fatty acids (Mus musculus)
GO:0102214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	omega-hydroxy fatty acyl-CoA synthetase activity
REACT:R-DRE-5696490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:CLCF1 binds CNTRF (Danio rerio)
REACT:R-DRE-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Danio rerio)
REACT:R-MMU-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)
REACT:R-HSA-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Homo sapiens)
REACT:R-DDI-9606894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DAPP1 (p-BAM32) binds PLCG2 (Dictyostelium discoideum)
RHEA:23832	skos:prefLabel	"N-acylmannosamine kinase"
RHEA:23832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)
RHEA:23832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acylmannosamine kinase"
RHEA:23832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-mannosamine = ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate
RHEA:21325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + reduced [rubredoxin] + superoxide => H2O2 + oxidized [rubredoxin]
REACT:R-MMU-5675656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA:EDAR binds EDARADD (Mus musculus)
REACT:R-RNO-8865320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX1 (Rattus norvegicus)
REACT:R-HSA-933530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of IKK by MEKK1 (Homo sapiens)
REACT:R-HSA-428293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF2BP2 binds specific RNAs (Homo sapiens)
REACT:R-SSC-391939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP receptor can bind thromboxane (Sus scrofa)
REACT:R-GGA-110232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by MBD4 glycosylase (Gallus gallus)
REACT:R-BTA-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Bos taurus)
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyllactosaminide 3-alpha-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyllactosaminide alpha-1,3-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity
GO:0047276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity
REACT:R-XTR-199203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK1/3/4 phosphorylate PanK (Xenopus tropicalis)
RHEA:26052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-4086036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate NRIP1 with SUMO1 (Homo sapiens)
EC:3.4.24.22	skos:altLabel	"transin 2"
EC:3.4.24.22	skos:prefLabel	"stromelysin 2"
EC:3.4.24.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stromelysin 2"
EC:3.4.24.22	skos:altLabel	"matrix metalloproteinase 10"
RHEA:23801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionine => 2-oxobutanoate + methanethiol + NH4(+)
REACT:R-CEL-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Caenorhabditis elegans)
REACT:R-HSA-5694417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
REACT:R-CFA-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Canis familiaris)
RHEA:16668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O <=> (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate
REACT:R-CFA-9657619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Canis familiaris)
RHEA:57615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH <=> 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)
RHEA:36248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trans-anol => H(+) + S-adenosyl-L-homocysteine + trans-anethole
REACT:R-HSA-3215310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)
GO:0106141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavin prenyltransferase activity
RHEA:67536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine
RHEA:42642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinol + S-adenosyl-L-methionine
RHEA:47276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-209868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
REACT:R-GGA-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Gallus gallus)
REACT:R-SCE-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Saccharomyces cerevisiae)
REACT:R-CEL-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Caenorhabditis elegans)
REACT:R-DME-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Drosophila melanogaster)
RHEA:14641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanurate + H2O = biuret + CO2
REACT:R-BTA-8850560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha releases G-protein heterotrimer from PDCL  (Bos taurus)
RHEA:66659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(out) + L-ascorbate(in) <=> Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)
REACT:R-HSA-5693578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDP1 and TDP2 process unligatable DSB ends (Homo sapiens)
RHEA:21313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxybenzoate + H(+) => CO2 + hydroquinone
REACT:R-DDI-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Dictyostelium discoideum)
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(10)-formyltetrahydropteroyldiglutamate synthetase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folylpoly-gamma-glutamate synthase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folylpoly(gamma-glutamate) synthase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyltetrahydropteroyldiglutamate synthetase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folylpolyglutamyl synthetase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrofolate synthase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FPGS activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N10-formyltetrahydropteroyldiglutamate synthetase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folylpolyglutamate synthase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folylpolyglutamate synthetase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydrofolylpolyglutamate synthase activity
GO:0004326	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	folate polyglutamate synthetase activity
REACT:R-PFA-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Plasmodium falciparum)
REACT:R-RNO-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Rattus norvegicus)
RHEA:52178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-3000112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)
RHEA:41130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine
REACT:R-CEL-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
REACT:R-MMU-976801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I complex formation (Mus musculus)
REACT:R-HSA-4755478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates IKBKE with SUMO1 (Homo sapiens)
REACT:R-RNO-8937989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRC1 complexes (Rattus norvegicus)
REACT:R-MMU-1602399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLB1 (Mus musculus)
REACT:R-XTR-5685605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF7 binds SLAMF7 (Xenopus tropicalis)
REACT:R-HSA-4755479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKB2 with SUMO1 (Homo sapiens)
REACT:R-XTR-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Xenopus tropicalis)
RHEA:53439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9668904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18 complex (Mus musculus)
REACT:R-MMU-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Mus musculus)
REACT:R-CFA-9632182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates ESRs (Canis familiaris)
REACT:R-BTA-202489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of Bcl10 (Bos taurus)
REACT:R-HSA-1963581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Homo sapiens)
REACT:R-DRE-8855564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Danio rerio)
GO:0051777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaurenoic acid oxidase activity
GO:0051777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaurenoate oxidase activity
GO:0051777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity
REACT:R-SSC-2161651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGE2 is converted to PGF2a by CBR1 (Sus scrofa)
RHEA:24781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-13(2)-carboxypyropheophorbide a + H(+) => CO2 + pyropheophorbide a
RHEA:30642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)
RHEA:65550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base => ganglioside Fuc-GM1 + H2O
RHEA:55721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate
RHEA:24637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + NAD(+) => H(+) + NADH
REACT:R-BTA-5433074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)
REACT:R-MMU-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Mus musculus)
REACT:R-XTR-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Xenopus tropicalis)
RHEA:52066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-octadecenoyloxy)-octadecanoate + H2O
REACT:R-RNO-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Rattus norvegicus)
REACT:R-CFA-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Canis familiaris)
RHEA:27466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) => ADP-D-glycero-beta-D-manno-heptose + diphosphate
RHEA:38264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O
REACT:R-GGA-5686315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Gallus gallus)
REACT:R-MMU-5690196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates RNF128 (Mus musculus)
REACT:R-MMU-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Mus musculus)
RHEA:64129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-L-phenylalanine => L-phenylalanine + octadecanoate
REACT:R-RNO-177944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)
REACT:R-CFA-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Canis familiaris)
REACT:R-SPO-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Schizosaccharomyces pombe)
REACT:R-SSC-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Sus scrofa)
REACT:R-DRE-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Danio rerio)
REACT:R-XTR-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Xenopus tropicalis)
REACT:R-HSA-192051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7A1 7-hydroxylates CHOL (Homo sapiens)
REACT:R-MMU-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Mus musculus)
REACT:R-CEL-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Caenorhabditis elegans)
REACT:R-MMU-8950340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Mus musculus)
REACT:R-DDI-994140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Dictyostelium discoideum)
RHEA:50490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein]
RHEA:18046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O => alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)
REACT:R-RNO-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Rattus norvegicus)
REACT:R-BTA-4755524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1I2 with SUMO3 (Bos taurus)
REACT:R-MMU-6786650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDHD1,2 hydrolyse PA (Mus musculus)
GO:0004910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1, type II, blocking receptor activity
GO:0004910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-1 type II, blocking binding
GO:0004910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1 type II receptor activity
GO:0004910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	interleukin-1, type II, blocking binding
GO:0004910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-1 type II, blocking receptor
GO:0004910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1 blocking receptor activity
REACT:R-HSA-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Homo sapiens)
REACT:R-XTR-9709883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB scavenges O2.- (Xenopus tropicalis)
GO:0080100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + scyllo-inosose = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate
GO:0080100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine:2-oxoglutarate aminotransferase activity
GO:0080100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine:alpha-ketoglutarate aminotransferase activity
GO:0080100	skos:altLabel	"glutamine--scyllo-inosose transaminase"
GO:0080100	skos:altLabel	"glutamine--scyllo-inosose aminotransferase"
GO:0080100	skos:prefLabel	"glutamine--scyllo-inositol transaminase"
GO:0080100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamine--scyllo-inositol transaminase"
REACT:R-HSA-3215426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Homo sapiens)
RHEA:21229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltose => beta-maltose
RHEA:50227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9702613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ponatinib-resistant FLT3 mutants don't bind ponatinib (Homo sapiens)
REACT:R-DRE-174255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation multiubiquitinated Cyclin A (Danio rerio)
REACT:R-SCE-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)
RHEA:63922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine => octadecanoyl-CoA + sphinga-4E,14Z-dienine
RHEA:36426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Danio rerio)
RHEA:37875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklanonate + S-adenosyl-L-methionine = methyl aklanonate + S-adenosyl-L-homocysteine
RHEA:37875	skos:prefLabel	"aklanonic acid methyltransferase"
RHEA:37875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aklanonic acid methyltransferase"
REACT:R-BTA-8937744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-7Y-RUNX1 (Bos taurus)
EC:2.7.14.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Protein-arginine kinases"
EC:2.7.14.-	skos:prefLabel	"Protein-arginine kinases"
REACT:R-CFA-389352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Vav1 to CD28 (Canis familiaris)
RHEA:64827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthaleneacetamide + H2O <=> 1-naphthaleneacetate + NH4(+)
RHEA:62298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide + 2 FADH2 => (+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+)
REACT:R-DME-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Drosophila melanogaster)
REACT:R-GGA-434073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88  (Gallus gallus)
REACT:R-XTR-73729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of SL1 (Xenopus tropicalis)
RHEA:34137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(9)-tetrahydrocannabinolate + H2O2 => cannabigerolate + O2
REACT:R-XTR-870449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 monoubiquitinates SMAD4 (Xenopus tropicalis)
REACT:R-RNO-388830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds ICOS (Rattus norvegicus)
RHEA:71413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out) => 3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in)
REACT:R-BTA-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Bos taurus)
REACT:R-MMU-8987220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Mus musculus)
REACT:R-DME-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)
RHEA:11881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2
REACT:R-SSC-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Sus scrofa)
REACT:R-SSC-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Sus scrofa)
REACT:R-SCE-1299304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Saccharomyces cerevisiae)
REACT:R-SCE-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Saccharomyces cerevisiae)
REACT:R-BTA-8874202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the cytosol to the nucleus (Bos taurus)
REACT:R-DDI-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)
REACT:R-MMU-6804596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1:CYCS binds APIP (Mus musculus)
REACT:R-MMU-205289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of KIT (Mus musculus)
RHEA:67481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + prekainate => CO2 + H2O + kainate + succinate
REACT:R-HSA-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Homo sapiens)
REACT:R-SSC-374787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR neuropeptide receptor binds neuropeptides B and W (Sus scrofa)
RHEA:40234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:68022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + phosphate => (2E)-geranyl phosphate + H2O
RHEA:44424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + heptadecasphing-4-enine = CoA + H(+) + N-acyl-heptadecasphing-4-enine
REACT:R-XTR-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Xenopus tropicalis)
RHEA:49151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-XTR-6801675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates NPM1 (Xenopus tropicalis)
RHEA:56983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzyl alcohol + 2 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]
RHEA:50793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => aldosterone + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Sus scrofa)
REACT:R-HSA-169461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 mediated fork unwinding (Homo sapiens)
RHEA:62864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine = 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-8986994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Bos taurus)
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyllactosamine beta(1,3)N-acetylglucosaminyltransferase activity
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GnTE activity
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:Galbeta-1,4-GlcNAcbeta-beta-1,3-N-acetylglucosaminyltransferase activity
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:Galbeta-(1,4)-GlcNAcbeta-r-beta-(1,3)-N-acetylglucosaminyltransferase activity
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uridine diphosphoacetylglucosamine-acetyllactosaminide beta-1,3-acetylglucosaminyltransferase
GO:0008532	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	poly-N-acetyllactosamine extension enzyme activity
RHEA:68150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-octan-2-ol + NADP(+) => 2-octanone + H(+) + NADPH
REACT:R-MMU-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Mus musculus)
REACT:R-XTR-9693478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A agonists (Xenopus tropicalis)
REACT:R-HSA-6800035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP3 binds TMEM219 (Homo sapiens)
RHEA:45206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl-Co(III)-[methanol-specific corrinoid protein] => Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol
REACT:R-DRE-3247569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADI4 deiminates Histones (Danio rerio)
REACT:R-GGA-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Gallus gallus)
RHEA:33170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol
REACT:R-SSC-8870678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fibrinogen products bind TLR4:LY96 (Sus scrofa)
REACT:R-GGA-5691381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYSM1 deubiquitinates Histone H2A (Gallus gallus)
REACT:R-RNO-6810410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Rattus norvegicus)
REACT:R-DRE-6788385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of ATR and ATRIP is recruited to ICL-DNA (Danio rerio)
REACT:R-DDI-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Dictyostelium discoideum)
REACT:R-HSA-6807064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces ZYMOL to ZYMSTNL (Homo sapiens)
REACT:R-CEL-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Caenorhabditis elegans)
REACT:R-PFA-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Plasmodium falciparum)
RHEA:17057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactosylacylglycerol O-acyltransferase"
RHEA:17057	skos:prefLabel	"galactosylacylglycerol O-acyltransferase"
RHEA:17057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]
REACT:R-HSA-8950757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)
REACT:R-RNO-6791219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Rattus norvegicus)
RHEA:60762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + jasmolin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone
RHEA:20506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-(gamma-L-glutamyl)-L-amino acid => 5-oxo-L-proline + an L-alpha-amino acid
REACT:R-HSA-6788556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to NDUFV1, V2 (Homo sapiens)
RHEA:30056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine + NADP(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADPH
RHEA:46800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:46800	skos:prefLabel	"ferredoxin--NAD(+) oxidoreductase (Na(+)-transporting)"
RHEA:46800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin--NAD(+) oxidoreductase (Na(+)-transporting)"
RHEA:46800	skos:altLabel	"Rnf complex"
RHEA:11544	skos:altLabel	"glycosylasparaginase"
RHEA:11544	skos:altLabel	"aspartylglucosaminidase"
RHEA:11544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase"
RHEA:11544	skos:altLabel	"N-aspartyl-beta-glucosaminidase"
RHEA:11544	skos:altLabel	"beta-aspartylglucosylamine amidohydrolase"
RHEA:11544	skos:altLabel	"aspartylglucosylamine deaspartylase"
RHEA:11544	skos:altLabel	"aspartylglucosylaminidase"
RHEA:11544	skos:altLabel	"aspartylglucosylaminase"
RHEA:11544	skos:prefLabel	"N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase"
RHEA:11544	skos:altLabel	"glucosylamidase"
RHEA:11544	skos:altLabel	"aspartylglycosylamine amidohydrolase"
RHEA:11544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine
RHEA:69477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysine => CoA + H(+) + N(6)-acetyl-L-lysine
REACT:R-CEL-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Caenorhabditis elegans)
RHEA:46482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2
RHEA:38313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daunorubicin + H(+) + S-adenosyl-L-homocysteine => carminomycin + S-adenosyl-L-methionine
REACT:R-HSA-535717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of calnexin/calreticulin to the unfolded protein (Homo sapiens)
RHEA:21569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose
REACT:R-SSC-5669024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD70 binds CD27 (Sus scrofa)
REACT:R-HSA-3321918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin (Homo sapiens)
GO:0102686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:trans-zeatin 9-N-glucosyltransferase
RHEA:64797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)
RHEA:23990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate => (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate
GO:0047881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estradiol 17-alpha-dehydrogenase activity
GO:0047881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity
GO:0047881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estradiol 17alpha-oxidoreductase activity
GO:0047881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17alpha-hydroxy steroid oxidoreductase activity
GO:0047881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17alpha-estradiol dehydrogenase activity
GO:0047881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estradiol 17a-dehydrogenase activity
GO:0047881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17alpha-hydroxy steroid dehydrogenase activity
GO:0047881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17alpha-hydroxysteroid oxidoreductase activity
GO:0047881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estradiol 17alpha-dehydrogenase activity
REACT:R-HSA-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Homo sapiens)
REACT:R-DDI-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Dictyostelium discoideum)
RHEA:59387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-amino-L-phenylalanine <=> 3-(4-aminophenyl)pyruvate + L-glutamate
RHEA:38331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol
REACT:R-DME-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Drosophila melanogaster)
RHEA:23174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]
REACT:R-MMU-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Mus musculus)
RHEA:52340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] = AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]
RHEA:37370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine <=> 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)
GO:0034216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity thiamin:hydrogen symporter activity
GO:0034216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity thiamine:proton symporter activity
GO:0034216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity thiamine:hydrogen symporter activity
GO:0034216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity thiamin:proton symporter activity
GO:0034216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity thiamin:hydrogen symporter activity
GO:0019887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase regulator activity
RHEA:12577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP
REACT:R-DRE-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Danio rerio)
RHEA:30424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-delta-selinene + diphosphate
RHEA:43149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine
REACT:R-MMU-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Mus musculus)
REACT:R-SSC-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Sus scrofa)
RHEA:10977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + quinolin-2-ol => 5,6-dihydroquinoline-2,5,6-triol + NAD(+)
REACT:R-SPO-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Schizosaccharomyces pombe)
REACT:R-MMU-9009536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX5 binds ESR1:estrogen:TFF1 gene promoter (Mus musculus)
RHEA:66555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[protein] + serotonin <=> 5-serotonyl-L-glutamyl-[protein] + NH4(+)
GO:0030628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-mRNA 3'-splice site binding
GO:0030628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-mRNA 3' splice site binding
RHEA:43834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA
REACT:R-HSA-983426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capturing cargo and formation of prebudding complex (Homo sapiens)
REACT:R-BTA-69299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds geminin (Bos taurus)
REACT:R-DRE-69140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap (Danio rerio)
RHEA:43768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkylamine + L-glutaminyl-[protein] = N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)
RHEA:34994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-ornithine(in) <=> L-arginine(in) + L-ornithine(out)
RHEA:60755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin I
RHEA:31724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Sus scrofa)
REACT:R-HSA-376149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic processing of SLIT (Homo sapiens)
REACT:R-RNO-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Rattus norvegicus)
REACT:R-CFA-203680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:NOSIP translocation from caveolae to intracellular compartments (Canis familiaris)
RHEA:38246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + eicosan-1-ol <=> 1-O-eicosanyl (9Z)-octadecenoate + CoA
RHEA:13126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glutathione disulfide => CoA-glutathione + glutathione
RHEA:35504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + uroporphyrin III(in) => ADP + H(+) + phosphate + uroporphyrin III(out)
REACT:R-SPO-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Schizosaccharomyces pombe)
REACT:R-MMU-984733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-3 is a dimer (Mus musculus)
RHEA:68351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP <=> diphosphate + pppA(2'-5')pG
REACT:R-RNO-2467665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds Beta amyloid fibril via GAG chains (Rattus norvegicus)
REACT:R-MMU-3247569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADI4 deiminates Histones (Mus musculus)
EC:1.1.1.281	skos:prefLabel	"GDP-4-dehydro-6-deoxy-D-mannose reductase"
EC:1.1.1.281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-4-dehydro-6-deoxy-D-mannose reductase"
EC:1.1.1.281	skos:altLabel	"GDP-4-keto-6-deoxy-D-mannose reductase"
EC:1.1.1.281	skos:altLabel	"GDP-6-deoxy-D-lyxo-4-hexulose reductase"
REACT:R-CEL-3928656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves EPHB2 (Caenorhabditis elegans)
REACT:R-HSA-9035169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CETP regulated by NR1H2 or NR1H3 (Homo sapiens)
GO:0102066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-patchoulene synthase activityy
REACT:R-DME-1369028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid efflux (Drosophila melanogaster)
GO:0140707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromatin-nuclear membrane anchor activity
GO:0043833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylamine-specific methylcobalamin:coenzyme M methyltransferase activity
GO:0043833	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methylcobamide:CoM methyltransferase activity
GO:0043833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylamine-specific methylcobalamin:CoM methyltransferase activity
GO:0043833	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	MT2-A
GO:0043833	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity
GO:0043833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity
GO:0043833	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methylcobamide:coenzyme M methyltransferase activity
RHEA:35884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-MMU-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Mus musculus)
RHEA:26081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate
RHEA:26081	skos:prefLabel	"(Z)-gamma-bisabolene synthase"
RHEA:26081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(Z)-gamma-bisabolene synthase"
REACT:R-RNO-1168459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lyn activates ERK (Rattus norvegicus)
REACT:R-BTA-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Bos taurus)
REACT:R-XTR-5682826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM11 (Xenopus tropicalis)
RHEA:42042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+) => ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose
GO:0032038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin II heavy chain binding
REACT:R-HSA-1254290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSN2 gene expression is stimulated by ERBB4s80:STAT5A (Homo sapiens)
REACT:R-GGA-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Gallus gallus)
RHEA:28523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate
RHEA:50187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine
RHEA:66280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solanidine + UDP-alpha-D-glucose = H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP
REACT:R-XTR-176494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to 27HCHOL (Xenopus tropicalis)
REACT:R-CFA-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Canis familiaris)
REACT:R-RNO-873921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of STAT1 to p-IFNGR1 (Rattus norvegicus)
REACT:R-XTR-202174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ZAP-70 (Xenopus tropicalis)
RHEA:69004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite = AMP + cremeomycin + diphosphate + H2O
RHEA:60026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-chrysanthemol + diphosphate => (R,R)-chrysanthemyl diphosphate + H2O
GO:0102854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-18:1-phosphatidylcholine desaturase activity
REACT:R-XTR-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Xenopus tropicalis)
REACT:R-RNO-6801342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)
REACT:R-HSA-9622363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds the promoter of the KLF5 gene (Homo sapiens)
REACT:R-HSA-9757451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA-,ST translocate from cytosol to ER lumen of hepatocytes (Homo sapiens)
REACT:R-XTR-5684108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 binds phosphorylated RBBP8 (Xenopus tropicalis)
REACT:R-BTA-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)
REACT:R-XTR-1650808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Xenopus tropicalis)
REACT:R-SSC-170153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Sus scrofa)
RHEA:51341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate
RHEA:10814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N-succinyl-L-glutamate + NADH => H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
REACT:R-CEL-8866553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded CFTR is degraded by the 26S proteasome (Caenorhabditis elegans)
REACT:R-DRE-5618085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Danio rerio)
REACT:R-GGA-210974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS-1 to Tie2 bound  Grb2 (Gallus gallus)
REACT:R-DME-6807875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Drosophila melanogaster)
REACT:R-DME-109449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Drosophila melanogaster)
RHEA:49041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-5'-demethylyatein + S-adenosyl-L-methionine => (-)-yatein + H(+) + S-adenosyl-L-homocysteine
GO:0070991	skos:altLabel	"fatty-acyl-CoA dehydrogenase"
GO:0070991	skos:altLabel	"acyl coenzyme A dehydrogenase"
GO:0070991	skos:altLabel	"acyl dehydrogenase"
GO:0070991	skos:altLabel	"fatty acyl coenzyme A dehydrogenase"
GO:0070991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"medium-chain acyl-CoA dehydrogenase"
GO:0070991	skos:prefLabel	"medium-chain acyl-CoA dehydrogenase"
GO:0070991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0070991	skos:altLabel	"acyl CoA dehydrogenase"
GO:0070991	skos:altLabel	"general acyl CoA dehydrogenase"
GO:0070991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAD activity
GO:0070991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	medium-chain-acyl-CoA dehydrogenase activity
REACT:R-PFA-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Plasmodium falciparum)
REACT:R-CFA-947531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Canis familiaris)
REACT:R-XTR-5675206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEA15 binds MAPK monomers and dimers (Xenopus tropicalis)
REACT:R-CEL-5649799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)
REACT:R-CFA-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Canis familiaris)
REACT:R-SCE-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Saccharomyces cerevisiae)
RHEA:42625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-ureidoacrylate + H(+) + H2O => (Z)-3-aminoacrylate + CO2 + NH4(+)
RHEA:45373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoate + sphinganine
REACT:R-HSA-9698762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 ITD- and STAT5-dependent NOX4 gene expression (Homo sapiens)
RHEA:14203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose => D-lyxose
RHEA:46270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-BTA-111253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Bos taurus)
RHEA:16207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]
RHEA:54101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-MMU-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Mus musculus)
RHEA:17591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-alanine + NADH + pyruvate => 2,2'-iminodipropanoate + H2O + NAD(+)
REACT:R-CEL-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Caenorhabditis elegans)
REACT:R-DME-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Drosophila melanogaster)
RHEA:25400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate
REACT:R-HSA-6786070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Homo sapiens)
RHEA:39516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)
REACT:R-XTR-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Xenopus tropicalis)
GO:0016530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metallochaperone activity
RHEA:33477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine
REACT:R-BTA-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Bos taurus)
RHEA:43598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2
REACT:R-RNO-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Rattus norvegicus)
REACT:R-RNO-8942607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Rattus norvegicus)
REACT:R-BTA-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Bos taurus)
RHEA:29035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamate(out) = ADP + H(+) + L-glutamate(in) + phosphate
REACT:R-MMU-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Mus musculus)
EC:6.7.1.-	skos:prefLabel	"Forming diazo bonds"
EC:6.7.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming diazo bonds"
RHEA:13417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xanthommatin reductase"
RHEA:13417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin
RHEA:13417	skos:prefLabel	"xanthommatin reductase"
REACT:R-MMU-6805109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates TP53 (Mus musculus)
RHEA:26137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine
REACT:R-GGA-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Gallus gallus)
RHEA:52480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate + NH4(+)
RHEA:22839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]
RHEA:35661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + mannosylinositol phosphorylphytoceramide => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose
REACT:R-DRE-111285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)
GO:0015296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anion:cation symporter activity
RHEA:47508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5beta-cholan-24-oate + H(+) + NADH = isolithocholate + NAD(+)
RHEA:47508	skos:prefLabel	"3beta-hydroxycholanate 3-dehydrogenase (NAD(+))"
RHEA:47508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3beta-hydroxycholanate 3-dehydrogenase (NAD(+))"
RHEA:47508	skos:altLabel	"3beta-hydroxysteroid dehydrogenase"
REACT:R-XTR-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Xenopus tropicalis)
REACT:R-XTR-1602458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP10 (Xenopus tropicalis)
REACT:R-BTA-73718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBF-1 Binds rDNA Promoter (Bos taurus)
REACT:R-BTA-110141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Bos taurus)
RHEA:32949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CoA => a 2-acylglycerol + an acyl-CoA
REACT:R-MMU-6783177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates GATA3,IL33 (Mus musculus)
REACT:R-SSC-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Sus scrofa)
REACT:R-BTA-9724745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds aprotinin (Bos taurus)
REACT:R-CFA-3769447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex deacetylate histones (Canis familiaris)
REACT:R-RNO-5696358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREM,CD300 binds lipids (Rattus norvegicus)
REACT:R-HSA-209055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)
RHEA:19385	skos:prefLabel	"vomilenine glucosyltransferase"
RHEA:19385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vomilenine glucosyltransferase"
RHEA:19385	skos:altLabel	"UDPG:vomilenine 21beta-D-glucosyltransferase"
RHEA:19385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vomilenine = H(+) + raucaffricine + UDP
REACT:R-DRE-2428930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Danio rerio)
REACT:R-DRE-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Danio rerio)
REACT:R-DRE-3785711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Telomere shortening during replicative exhaustion (Danio rerio)
REACT:R-SCE-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Saccharomyces cerevisiae)
RHEA:59076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)
RHEA:59076	skos:altLabel	"MDIP synthase"
RHEA:59076	skos:prefLabel	"GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase"
RHEA:59076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase"
RHEA:20743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trans-2,3-epoxysuccinate <=> (2R,3S)-tartrate
RHEA:19244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Danio rerio)
RHEA:46611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[protein] <=> ADP + H(+) + O-phospho-L-threonyl-[protein]
REACT:R-GGA-1236941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of receptor bound antigen into clathrin coted vesicles (Gallus gallus)
REACT:R-RNO-453200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Rattus norvegicus)
RHEA:66696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)
REACT:R-SSC-8942101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 monoubiquitinates Histone H2B (Sus scrofa)
REACT:R-MMU-5674019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds KSR1:MARK3 (Mus musculus)
RHEA:17164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> 2-oxopent-4-enoate + benzoate + H(+)
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPCRK
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR phosphorylating protein kinase activity
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GRK5
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GRK4
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein-coupled receptor phosphorylating protein kinase activity
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled receptor kinase activity
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled receptor phosphorylating protein kinase activity
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	G-protein coupled receptor kinase activity
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK16
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GRK6
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:G-protein-coupled receptor phosphotransferase activity
GO:0004703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPCR kinase activity
REACT:R-DRE-182594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of INK4 family proteins with CDK4/6 (Danio rerio)
RHEA:55787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate <=> all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP
REACT:R-CFA-5682629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Canis familiaris)
REACT:R-DRE-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Danio rerio)
RHEA:15518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2),6-disulfo-D-glucosamine => H(+) + N-sulfo-D-glucosamine + sulfate
REACT:R-DME-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Drosophila melanogaster)
REACT:R-MMU-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Mus musculus)
REACT:R-XTR-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Xenopus tropicalis)
REACT:R-RNO-170796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports GCK1:GKRP from cytosol to nucleoplasm (Rattus norvegicus)
RHEA:53060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-DME-9718379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds chemical antagonists (Drosophila melanogaster)
RHEA:38259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-beta-methylmalyl-CoA = glyoxylate + propanoyl-CoA
REACT:R-SPO-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Schizosaccharomyces pombe)
RHEA:63559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynorphin A-(1-13) + H2O <=> dynorphin A-(1-12) + L-lysine
REACT:R-HSA-975147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)
RHEA:44893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose => an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP
GO:0000704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine dimer DNA N-glycosylase activity
REACT:R-MMU-5634221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 binds TRAF2 within TNFR1 signaling complex (Mus musculus)
REACT:R-GGA-1358789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Self-ubiquitination of RNF41 (Gallus gallus)
REACT:R-RNO-420233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VIP receptors bind VIP (Rattus norvegicus)
RHEA:62393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	levoglucosan + NAD(+) => 3-dehydrolevoglucosan + H(+) + NADH
GO:0052844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
REACT:R-HSA-3769447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex deacetylate histones (Homo sapiens)
RHEA:17961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = H2O + leukotriene A4
RHEA:43606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin]
REACT:R-RNO-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Rattus norvegicus)
RHEA:67288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine = (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine
RHEA:45205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol => H2O + methyl-Co(III)-[methanol-specific corrinoid protein]
REACT:R-DME-8949649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Drosophila melanogaster)
RHEA:71752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + glutarate(in) => 2-oxoglutarate(in) + glutarate(out)
GO:0052743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol tetrakisphosphate phosphatase activity
RHEA:57131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 oxidized [azurin] + tyramine <=> (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]
RHEA:51819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)
RHEA:35644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH
RHEA:53253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:41045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA
REACT:R-SSC-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Sus scrofa)
REACT:R-CFA-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Canis familiaris)
REACT:R-CFA-6799203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Canis familiaris)
REACT:R-DDI-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)
RHEA:67114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine
RHEA:26098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)
RHEA:43416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DRE-1614654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Danio rerio)
REACT:R-SCE-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Saccharomyces cerevisiae)
REACT:R-SSC-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Sus scrofa)
REACT:R-CFA-9034855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK3 (Canis familiaris)
RHEA:44226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 16-hydroxyhexadecanoate + ATP + CoA
RHEA:68738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:34838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine <=> a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine
RHEA:42286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:28810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + H2O <=> L-cysteinylglycine + L-glutamate
REACT:R-DRE-9639287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2 binds L-leucine and dissociates from GATOR2 (Danio rerio)
REACT:R-HSA-8939801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
REACT:R-HSA-2214324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII dimerization (Homo sapiens)
REACT:R-CFA-165162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TSC2 by PKB (Canis familiaris)
RHEA:16927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-caffeoyl-CoA + S-adenosyl-L-methionine
REACT:R-CEL-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)
RHEA:18279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a methyl thioether + H(+) + S-adenosyl-L-homocysteine => a thiol + S-adenosyl-L-methionine
RHEA:52465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:34766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate(out) + succinate(in) <=> (S,S)-tartrate(in) + succinate(out)
REACT:R-RNO-378978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Rattus norvegicus)
RHEA:70074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + sitosterol <=> (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:58726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine => adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine
GO:0008765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
GO:0008765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)
GO:0008765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity
GO:0008765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MurE synthetase activity
GO:0008765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity
GO:0008765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylmuramyl-tripeptide synthetase activity
REACT:R-MMU-202702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD177 binds PECAM-1 (Mus musculus)
RHEA:64131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-L-phenylalanine <=> L-phenylalanine + octadecanoate
RHEA:46044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA
RHEA:20606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine + H(+) + H2O => NH4(+) + uracil
REACT:R-RNO-9700154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds SHC1 (Rattus norvegicus)
GO:0018705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dichloroethene reductive dehalogenase activity
GO:0018705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dichloroethylene reductive dehalogenase activity
GO:0016157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-fructose glucosyltransferase activity
GO:0016157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-fructose glucosyltransferase activity
GO:0016157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose-uridine diphosphate glucosyltransferase activity
GO:0016157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-fructose glucosyltransferase activity
GO:0016157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose synthase activity
GO:0016157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose-UDP glucosyltransferase activity
GO:0016157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity
GO:0016157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose synthetase activity
REACT:R-GGA-914012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Gallus gallus)
RHEA:11068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose
RHEA:11068	skos:prefLabel	"protein-glucosylgalactosylhydroxylysine glucosidase"
RHEA:11068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-glucosylgalactosylhydroxylysine glucosidase"
REACT:R-DRE-2046084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Danio rerio)
RHEA:57023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apulose + ATP <=> ADP + apulose 4-phosphate + H(+)
RHEA:30574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine <=> 6 AMP + 6 diphosphate + enterobactin + 4 H(+)
RHEA:22440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-galactose--UDP-N-acetylglucosamine galactose phosphotransferase"
RHEA:22440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine = H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP
RHEA:22440	skos:prefLabel	"UDP-galactose--UDP-N-acetylglucosamine galactose phosphotransferase"
REACT:R-XTR-9627104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP3 (Xenopus tropicalis)
RHEA:64288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] = cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9605414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH4 binds SMAD3 (Homo sapiens)
GO:0140767	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein-substrate adaptor activity
GO:0140767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme-substrate adaptor activity
REACT:R-BTA-975629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)
RHEA:51967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-917730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Recognition And Sorting (Gallus gallus)
REACT:R-XTR-1855179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Xenopus tropicalis)
RHEA:52415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + NAD(+) <=> 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH
RHEA:52121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5684267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
RHEA:69790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminophenyl)succinate + succinyl-CoA <=> 3-(2-aminophenyl)succinyl-CoA + succinate
REACT:R-DRE-6782138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC5 and RPA bind TC-NER site (Danio rerio)
RHEA:35055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichlorocatechol + O2 = (2E,4E)-2,5-dichloromuconate + H(+)
REACT:R-SSC-2730889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)
REACT:R-GGA-8944257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIV (Gallus gallus)
REACT:R-HSA-1462005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-defensin alpha 5 is secreted (Homo sapiens)
REACT:R-CFA-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Canis familiaris)
REACT:R-XTR-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Xenopus tropicalis)
REACT:R-BTA-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Bos taurus)
RHEA:69589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + UMP => IMP + uridine
REACT:R-HSA-170796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)
REACT:R-BTA-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
RHEA:44871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol <=> 1,2-diacyl-sn-glycero-3-phosphoethanol + choline
RHEA:16073	skos:prefLabel	"2,2-dialkylglycine decarboxylase (pyruvate)"
RHEA:16073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dialkylglycine + H(+) + pyruvate = CO2 + dialkyl ketone + L-alanine
RHEA:16073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,2-dialkylglycine decarboxylase (pyruvate)"
RHEA:16073	skos:altLabel	"L-alanine-alpha-ketobutyrate aminotransferase"
RHEA:40091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxyhexacosanoate + NAD(+) = 26-oxohexacosanoate + H(+) + NADH
RHEA:58179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + 2 diphosphate + NADP(+)
REACT:R-SCE-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)
REACT:R-CFA-419428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR2-5 bind S1P (Canis familiaris)
REACT:R-SPO-194678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)
RHEA:10162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-L-sorbose + NADH => L-iditol + NAD(+)
REACT:R-CFA-8981610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin binds oxygen (Canis familiaris)
RHEA:60630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + progoitrin => AH2 + gluconapin + O2
REACT:R-BTA-9750942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP14 deubiquitinates NLRC5 (Bos taurus)
REACT:R-SPO-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Schizosaccharomyces pombe)
RHEA:65272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin C + H(+) + NADPH + O2 = chrodrimanin H + H2O + NADP(+)
REACT:R-MMU-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Mus musculus)
REACT:R-RNO-5696007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF3 ligates CoA-SH to VLCFA (Rattus norvegicus)
RHEA:23098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+) => 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP
REACT:R-DRE-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Danio rerio)
REACT:R-BTA-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Bos taurus)
REACT:R-GGA-199404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40L binds CD40 (Gallus gallus)
RHEA:66600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dopamine + O2 = 2 dopamine quinone + 2 H2O
RHEA:61581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) => (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH
REACT:R-HSA-990526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)
REACT:R-DDI-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Dictyostelium discoideum)
REACT:R-SSC-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Sus scrofa)
REACT:R-BTA-8855711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Bos taurus)
RHEA:42578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoate + 2-oxopent-4-enoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O
REACT:R-DDI-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Dictyostelium discoideum)
REACT:R-BTA-914017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Bos taurus)
RHEA:43183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-1237047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ hydrates CO2 to HCO3- (Xenopus tropicalis)
REACT:R-SSC-429449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk activation leads to SLP-76 activation (Sus scrofa)
REACT:R-DME-381262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPARG:RXRA heterodimer (ARF6 complex) (Drosophila melanogaster)
RHEA:28842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Zn(2+)(in) <=> H(+)(in) + Zn(2+)(out)
RHEA:29209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone(in) + dimethyl sulfide(out) + H2O(out) => a menaquinol(in) + dimethyl sulfoxide(out)
RHEA:65809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Xenopus tropicalis)
REACT:R-XTR-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Xenopus tropicalis)
GO:0018494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carvone reductase activity
REACT:R-DDI-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Dictyostelium discoideum)
REACT:R-XTR-9750555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Xenopus tropicalis)
REACT:R-XTR-5688786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds RAD23 (Xenopus tropicalis)
RHEA:10394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamaldehyde + H(+) + NADPH => (E)-cinnamyl alcohol + NADP(+)
RHEA:13843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)2-[transferrin] + NADH => Fe(II)2-[transferrin] + H(+) + NAD(+)
REACT:R-GGA-69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Gallus gallus)
RHEA:34331	skos:prefLabel	"indole-3-pyruvate monooxygenase"
RHEA:34331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-pyruvate monooxygenase"
RHEA:34331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate + CO2 + H2O + NADP(+)
RHEA:22674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + presqualene diphosphate => 2 (2E,6E)-farnesyl diphosphate
REACT:R-DME-9647999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCE1 cleaves S-Farn proRAS proteins (Drosophila melanogaster)
REACT:R-MMU-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)
REACT:R-DME-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Drosophila melanogaster)
REACT:R-BTA-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Bos taurus)
REACT:R-HSA-8853908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX stimulates CSF1R (M-CSF-R) expression (Homo sapiens)
REACT:R-HSA-113454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Termination and release of transcribed RNA (Homo sapiens)
REACT:R-CFA-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Canis familiaris)
RHEA:21288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + sn-glycerol 3-phosphate = D-glucose 6-phosphate + glycerol
RHEA:21288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-3-phosphate--glucose phosphotransferase"
RHEA:21288	skos:prefLabel	"glycerol-3-phosphate--glucose phosphotransferase"
REACT:R-DME-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Drosophila melanogaster)
RHEA:60513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in miRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine
RHEA:11907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4-hydroxypteridine + H(+) + H2O <=> 2,4-dihydroxypteridine + NH4(+)
REACT:R-SSC-5654647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
REACT:R-CFA-73722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of UBF-1:rDNA Promoter (Canis familiaris)
RHEA:67876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine = 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-DRE-6807052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBP isomerizes ZYMSTNL to LTHSOL (Danio rerio)
REACT:R-BTA-5687664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)
RHEA:35668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)
REACT:R-SCE-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Saccharomyces cerevisiae)
REACT:R-DDI-5692283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)
REACT:R-XTR-113402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:early elongation complex (Xenopus tropicalis)
EC:3.1.3.-	skos:prefLabel	"Phosphoric monoester hydrolases"
EC:3.1.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphoric monoester hydrolases"
REACT:R-HSA-350745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Calumenin  (Homo sapiens)
REACT:R-SSC-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Sus scrofa)
RHEA:30074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + butanoate <=> acetate + butanoyl-CoA
RHEA:36030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + propanal <=> H(+) + NADH + propanoyl-CoA
RHEA:22107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + nicotianamine <=> 3''-deamino-3''-oxonicotianamine + L-glutamate
REACT:R-CFA-8950780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 binds p-Y693-STAT4 (Canis familiaris)
REACT:R-DME-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Drosophila melanogaster)
RHEA:35135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-L-glutamate(out) = L-alanyl-L-glutamate(in)
RHEA:14961	skos:prefLabel	"S-formylglutathione hydrolase"
RHEA:14961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-formylglutathione = formate + glutathione + H(+)
RHEA:14961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-formylglutathione hydrolase"
RHEA:36733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-nitrocyclohexene + H(+) + NADPH => 1-nitrocyclohexan + NADP(+)
RHEA:47606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GP1calpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E))
RHEA:47266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + ATP + CoA
REACT:R-RNO-5423647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2A13 oxidises AFM1 to AFM1E (Rattus norvegicus)
REACT:R-RNO-917888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF binds 2Fe3+ to form holoTF (Rattus norvegicus)
RHEA:66063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxohexanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminohexanoate
RHEA:52769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O => 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate
REACT:R-CFA-9664881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Canis familiaris)
RHEA:28971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + shikimate(in) = H(+)(out) + shikimate(out)
RHEA:56890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-dehydro-beta-L-rhamnose => UDP-4-dehydro-6-deoxy-alpha-D-glucose
REACT:R-CEL-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Caenorhabditis elegans)
RHEA:72938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(out) + 2 Na(+)(out) <=> (S)-lactate(in) + 2 Na(+)(in)
REACT:R-RNO-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)
REACT:R-HSA-8935785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 (Homo sapiens)
REACT:R-SPO-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Schizosaccharomyces pombe)
RHEA:44800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) = 2-demethylmenaquinol-6 + CO2 + diphosphate
RHEA:68138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-phenylethanol + NADP(+) => acetophenone + H(+) + NADPH
RHEA:34047	skos:prefLabel	"6'''-hydroxyneomycin C oxidase"
RHEA:34047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6'''-hydroxyneomycin C oxidase"
RHEA:34047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2
REACT:R-CEL-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Caenorhabditis elegans)
REACT:R-HSA-8961895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA1 gene expression is stimulated by E2F1 (Homo sapiens)
RHEA:60847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-guanosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate
GO:0001884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine nucleoside binding
REACT:R-BTA-1964501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Bos taurus)
RHEA:18035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => benzoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:68677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) => adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)
RHEA:16329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 = (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate
RHEA:33752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
REACT:R-SSC-5244692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)
REACT:R-RNO-4341072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RARA with SUMO2 (Rattus norvegicus)
RHEA:17680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O <=> 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)
REACT:R-HSA-2465924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1LW binds 11cRAL (Homo sapiens)
REACT:R-BTA-6807578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface in the phagosome (Bos taurus)
RHEA:48382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose
RHEA:71650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain (3S)-3-hydroxyacyl-CoA <=> a medium-chain (2E)-enoyl-CoA + H2O
RHEA:33873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NH4(+) + urea => (S)-2-ureidoglycine + H2O
REACT:R-BTA-5687121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPKAPK5 phosphorylates HSPB1 (Bos taurus)
REACT:R-CFA-8876868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE1 cleaves EDN1(53-90) (Canis familiaris)
RHEA:49374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + protoviolaceinate => H(+) + NADH + O2 + protodeoxyviolaceinate
REACT:R-BTA-1855197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)
REACT:R-DME-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Drosophila melanogaster)
REACT:R-SSC-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Sus scrofa)
REACT:R-DME-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)
REACT:R-HSA-8950637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of cell division cycle 42 (Homo sapiens)
REACT:R-DRE-3108203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO2,3 (Danio rerio)
REACT:R-SSC-8854628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLIP dimer ubiquitinates VLDLR on Lys-839 (Sus scrofa)
RHEA:13700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose <=> ADP + D-ribose 5-phosphate + H(+)
GO:0050112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol:NAD 2-dehydrogenase activity
GO:0050112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 2-dehydrogenase activity
GO:0050112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol 2-dehydrogenase activity
REACT:R-HSA-5602549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective TLR3 does not bind viral dsRNA (Homo sapiens)
REACT:R-HSA-9683687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein is SUMOylated (Homo sapiens)
REACT:R-CFA-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Canis familiaris)
RHEA:46179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoate + ATP + CoA <=> 2-methylpropanoyl-CoA + AMP + diphosphate
RHEA:41895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoyl-[ACP] <=> (2E)-tetradecenoyl-[ACP] + H2O
RHEA:47245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)
RHEA:21750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methylglyoxal + NADPH => (S)-lactaldehyde + NADP(+)
RHEA:48148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b (d18:1(4E)/18:0) + H2O = ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate
RHEA:71702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-phenylalanyl-L-leucine(out) <=> H(+)(in) + L-phenylalanyl-L-leucine(in)
REACT:R-CFA-1475026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)
RHEA:17595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate + L-phenylalanine => 3-phenylpyruvate + L-glutamine
RHEA:46640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)
RHEA:15438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + CoA + NADP(+) => a long-chain fatty acyl-CoA + H(+) + NADPH
GO:0032141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single cytosine insertion binding
REACT:R-DME-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Drosophila melanogaster)
RHEA:57534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate => a 5'-end ribonucleotide-RNA + ATP + H(+)
GO:0001068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription regulatory region RNA binding
REACT:R-SSC-200421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of cytosolic AMPK by phosphorylation (Sus scrofa)
RHEA:15638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alginate](n) + GDP-alpha-D-mannuronate => [alginate](n+1) + GDP + H(+)
REACT:R-XTR-5682965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Xenopus tropicalis)
RHEA:44319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoylglycerol + H2O <=> dodecanoate + glycerol + H(+)
RHEA:67373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-seryl-L-threonine => L-serine + L-threonine
RHEA:40562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-evernosamine + NADPH + O2 <=> dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)
REACT:R-DRE-5690023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL binds 4Fe-4S (Danio rerio)
RHEA:35597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + maleylacetate => benzene-1,2,4-triol + O2
REACT:R-CEL-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Caenorhabditis elegans)
REACT:R-CFA-2028670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Canis familiaris)
RHEA:19715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA
GO:0017172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine dioxygenase activity
REACT:R-DRE-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Danio rerio)
GO:0071987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WD domain binding
GO:0071987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WD40-repeat domain binding
GO:0071987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-transducin repeat domain binding
GO:0051116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)
GO:0051116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobaltochelatase activity
GO:0051116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogenobyrinic acid a,c-diamide cobaltochelatase activity
GO:0051116	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CobNST
GO:0051116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobN-CobST
REACT:R-HSA-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Homo sapiens)
REACT:R-HSA-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)
REACT:R-GGA-5654566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Gallus gallus)
REACT:R-MMU-429567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Mus musculus)
RHEA:42480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)
RHEA:31485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP => soyasapogenol E + UDP-alpha-D-glucuronate
GO:0010852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclase inhibitor activity
REACT:R-PFA-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Plasmodium falciparum)
RHEA:26493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary nitroalkane + H2O + O2 <=> a ketone + H(+) + H2O2 + nitrite
REACT:R-DME-5654147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PLCG1 (Drosophila melanogaster)
REACT:R-HSA-5694126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C3B hydrolyses 7MGP to 7MG (Homo sapiens)
REACT:R-DRE-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Danio rerio)
RHEA:40176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octanoyl-CoA => (2E)-octenoyl-CoA + H2O2
RHEA:39696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)
RHEA:22425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-alkyl-L-cysteine + H2O => an alkyl thiol + NH4(+) + pyruvate
REACT:R-GGA-8964605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Gallus gallus)
GO:0030773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymellein O-methyltransferase activity
GO:0030773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-hydroxymellein methyltransferase activity
GO:0030773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity
GO:0102661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate solanyltransferase activity
REACT:R-DRE-265682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Danio rerio)
REACT:R-RNO-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)
REACT:R-SSC-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Sus scrofa)
REACT:R-HSA-9702618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quizartinib-resistant FLT3 mutants don't bind quizartinib (Homo sapiens)
REACT:R-CFA-209910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is taken up by thyroid epithelial cells (Canis familiaris)
GO:0009973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine 5'-phosphosulfate reductase
GO:0009973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)
GO:0009973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylyl-sulfate reductase activity
GO:0009973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine phosphosulfate reductase activity
GO:0009973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)
GO:0009973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APS-reductase
GO:0009973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APS reductase activity
GO:0009973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylyl-sulphate reductase activity
RHEA:21720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanide hydratase"
RHEA:21720	skos:prefLabel	"cyanide hydratase"
RHEA:21720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formamide = H2O + hydrogen cyanide
RHEA:21720	skos:altLabel	"formamide hydro-lyase"
RHEA:32284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => H(+) + H2O + quinolinate
REACT:R-BTA-202174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ZAP-70 (Bos taurus)
RHEA:56053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
REACT:R-HSA-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Homo sapiens)
REACT:R-RNO-997314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)
REACT:R-RNO-1299338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRESK (Rattus norvegicus)
RHEA:28750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+)(in) <=> NH4(+)(out)
RHEA:24250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + pyruvate => glyoxylate + L-alanine
REACT:R-BTA-8848005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 promotes PTK6 autophosphorylation (Bos taurus)
REACT:R-MMU-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Mus musculus)
REACT:R-RNO-1606839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Steryl sulfatase hydrolyses sulfate from steroid sulfates (Rattus norvegicus)
RHEA:10409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA => 3-oxopristanoyl-CoA + CoA
RHEA:53627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + tsukubadiene
REACT:R-CFA-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Canis familiaris)
RHEA:39630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA <=> (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O
REACT:R-BTA-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Bos taurus)
RHEA:45432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate
RHEA:66333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate(out) => L-aspartate(in)
REACT:R-HSA-77329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Homo sapiens)
REACT:R-CFA-5626988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds NSMAF (Canis familiaris)
REACT:R-RNO-8864595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2B homodimer binds YEATS4 (Rattus norvegicus)
REACT:R-CFA-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Canis familiaris)
GO:0071253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	connexin binding
RHEA:49775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoylglycine
RHEA:16139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-deamino-3''-oxonicotianamine + H(+) + NADPH => 2'-deoxymugineate + NADP(+)
REACT:R-DME-204008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC31:SEC13 and v-SNARE recruitment (Drosophila melanogaster)
GO:0061798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP 3',8'-cyclase activity
GO:0098622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenodiglutathione-disulfide reductase activity
RHEA:33374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]
RHEA:56556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = delta-cadinene + diphosphate
RHEA:29684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltohexaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltopentaose
REACT:R-RNO-2889070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B2 exchanges Na+ for H+ (Rattus norvegicus)
REACT:R-MMU-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Mus musculus)
REACT:R-XTR-4656914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKBIA with SUMO1 (Xenopus tropicalis)
RHEA:26500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose
REACT:R-MMU-77319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Mus musculus)
RHEA:36184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-GGA-68954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm2-7 is phosphorylated by DDK (Gallus gallus)
RHEA:23056	skos:prefLabel	"cyanamide hydratase"
RHEA:23056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanamide hydratase"
RHEA:23056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea = cyanamide + H2O
RHEA:16416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]
REACT:R-CFA-9007539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates E2F6 (Canis familiaris)
REACT:R-RNO-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Rattus norvegicus)
RHEA:54768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide
EC:2.4.99.8	skos:prefLabel	"alpha-N-acetylneuraminate alpha-2,8-sialyltransferase"
EC:2.4.99.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-N-acetylneuraminate alpha-2,8-sialyltransferase"
EC:2.4.99.8	skos:altLabel	"alpha-2,8-sialyltransferase"
REACT:R-MMU-1250189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)
REACT:R-HSA-994137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Homo sapiens)
REACT:R-SCE-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Saccharomyces cerevisiae)
RHEA:71726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) <=> H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)
REACT:R-DRE-2046239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular KSPG translocates to the lysosome for degradation (Danio rerio)
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoriboisomerase activity
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose phosphate isomerase activity
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose-5-phosphate ketol-isomerase activity
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose-5-phosphate aldose-ketose-isomerase activity
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose-5-phosphate isomerase activity
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphoribose isomerase activity
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentose phosphate isomerase (PPI)
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate epimerase activity
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate isomerase activity
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopentosisomerase activity
GO:0004751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopentoseisomerase activity
REACT:R-MMU-416358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) inhibits PI3K alpha (Mus musculus)
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTC(4) synthase activity
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene C(4) synthetase activity
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTC4 synthetase activity
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene A(4):glutathione S-leukotrienyltransferase activity
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene C4 synthetase activity
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTC(4) synthetase activity
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leukotriene A4:glutathione S-leukotrienyltransferase activity
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LTC4 synthase activity
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene-C4 synthase activity
GO:0004464	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
REACT:R-CFA-174105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)
RHEA:43363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + UDP-alpha-D-glucose <=> an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP
REACT:R-SCE-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Saccharomyces cerevisiae)
REACT:R-HSA-9694661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
RHEA:61438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + phosphate => ADP + H2O
REACT:R-GGA-9017797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds YBX1 (Gallus gallus)
RHEA:46035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + tetradecanoate <=> (2S)-hydroxytetradecanoate + H2O
REACT:R-RNO-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Rattus norvegicus)
REACT:R-GGA-5358513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Gallus gallus)
GO:0033843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xyloglucan 6-xylosyltransferase activity
GO:0033843	skos:altLabel	"xyloglucan 6-alpha-D-xylosyltransferase"
GO:0033843	skos:prefLabel	"xyloglucan 6-xylosyltransferase"
GO:0033843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity
GO:0033843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xyloglucan 6-xylosyltransferase"
GO:0033843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity
GO:0033843	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xyloglucan 6-alpha-D-xylosyltransferase activity
GO:0033843	skos:altLabel	"uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase"
REACT:R-SCE-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Saccharomyces cerevisiae)
RHEA:31037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene + H2O => arabidiol
REACT:R-BTA-193665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYD88 dissociates (Bos taurus)
RHEA:38129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol
REACT:R-DRE-179467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Danio rerio)
REACT:R-DME-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Drosophila melanogaster)
REACT:R-XTR-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Xenopus tropicalis)
RHEA:70105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	penilactone B => H(+) + o-quinone methide + penilactone D
REACT:R-MMU-4837364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of SOD3 (Mus musculus)
REACT:R-BTA-158333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Bos taurus)
REACT:R-DRE-9038052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GREB1 binds ESR1:ESTG and co-activators (Danio rerio)
REACT:R-CEL-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Caenorhabditis elegans)
RHEA:60172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA
REACT:R-CEL-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Caenorhabditis elegans)
REACT:R-SSC-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Sus scrofa)
REACT:R-SPO-9036727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAA hydrolyzes lysosomal glycogen (Schizosaccharomyces pombe)
REACT:R-MMU-508292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds IL2RB (Mus musculus)
RHEA:64430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-proline(in) + H(+)(in) => glycyl-L-proline(out) + H(+)(out)
REACT:R-HSA-446211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Flipping of dolichyl-phosphate-glucose into the ER lumen (Homo sapiens)
RHEA:63147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)-ethanolamine <=> (15Z)-tetracosenoate + ethanolamine
REACT:R-DRE-5684006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translocates NBN to the nucleus (Danio rerio)
REACT:R-BTA-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Bos taurus)
REACT:R-GGA-8954110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1:EPC1 binds the PRC2 complex (Gallus gallus)
RHEA:26079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + NAD(+) + sulfite => methanesulfonate + NADH + O2
REACT:R-SSC-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Sus scrofa)
RHEA:34635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pentalenolactone D synthase"
RHEA:34635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + pentalenolactone D
RHEA:34635	skos:prefLabel	"pentalenolactone D synthase"
GO:0097098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA/RNA hybrid annealing activity
REACT:R-GGA-1964501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Gallus gallus)
REACT:R-CFA-9686922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 binds activated RIPK1:RIPK3 (Canis familiaris)
RHEA:60813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A12 aldehyde + O2 => CO2 + gibberellin A12 + H(+) + succinate
GO:0046993	skos:prefLabel	"With oxygen as acceptor"
GO:0046993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
GO:0046993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor
RHEA:50985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E2(out) => prostaglandin E2(in)
REACT:R-HSA-3134914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin migrates to the nucleus (Homo sapiens)
REACT:R-BTA-1977958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with ERBB3 (Bos taurus)
REACT:R-HSA-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Homo sapiens)
REACT:R-CEL-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)
REACT:R-SSC-6783681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIF binds LIFR (Sus scrofa)
REACT:R-MMU-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Mus musculus)
REACT:R-DME-5672980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF complex (Drosophila melanogaster)
REACT:R-HSA-4088141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PPP2R2A dephosphorylates FOXM1 (Homo sapiens)
REACT:R-CFA-8852266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Canis familiaris)
RHEA:56752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:56752	skos:prefLabel	"sterol 14alpha-demethylase (ferredoxin)"
RHEA:56752	skos:altLabel	"CYP51"
RHEA:56752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sterol 14alpha-demethylase (ferredoxin)"
REACT:R-MMU-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Mus musculus)
REACT:R-SPO-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)
RHEA:42975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a cardiolipin + ethanolamine
RHEA:61892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)
REACT:R-RNO-8955010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRTOMT transfers Met to DA, forming 3MT (Rattus norvegicus)
RHEA:16076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dialkylglycine + H(+) + pyruvate <=> CO2 + dialkyl ketone + L-alanine
EC:3.4.23.25	skos:altLabel	"yeast endopeptidase A"
EC:3.4.23.25	skos:altLabel	"Saccharomyces aspartic proteinase"
EC:3.4.23.25	skos:prefLabel	"saccharopepsin"
EC:3.4.23.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"saccharopepsin"
RHEA:68480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxyhexadecanoate + H(+) = CO2 + H2O + pentadecanal
RHEA:45694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(octanoyl)-sphing-4-enine-1-phosphate(out) => N-(octanoyl)-sphing-4-enine-1-phosphate(in)
RHEA:23943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH
REACT:R-GGA-2132264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of alternate C5 convertase (Gallus gallus)
GO:0008691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity
GO:0008691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity
GO:0008691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxybutyryl-CoA dehydrogenase activity
GO:0008691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutyryl-CoA dehydrogenase activity
GO:0008691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)
GO:0008691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxybutyryl coenzyme A dehydrogenase activity
GO:0008691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BHBD activity
GO:0008691	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L(+)-3-hydroxybutyryl-CoA dehydrogenase activity
RHEA:37862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA <=> 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-4420083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Homo sapiens)
GO:0102885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-cuprenene synthase activity
RHEA:21079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + 2-oxoglutarate + O2 <=> CO2 + succinate + uridine
REACT:R-MMU-2064421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds ZO-2 (TJP2) (Mus musculus)
REACT:R-SSC-109700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT2 binds PIP3 (Sus scrofa)
GO:0070410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	common-partner SMAD binding
GO:0070410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	common-mediator SMAD binding
GO:0070410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	co-SMAD binding
GO:0070410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	common mediator SMAD binding
GO:0070410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	common partner SMAD binding
REACT:R-XTR-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Xenopus tropicalis)
REACT:R-HSA-9754830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR8 dimer binds SARS-CoV-2 GU-rich ssRNA  (Homo sapiens)
EC:3.4.24.20	skos:altLabel	"Armillaria mellea neutral proteinase"
EC:3.4.24.20	skos:prefLabel	"peptidyl-Lys metalloendopeptidase"
EC:3.4.24.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidyl-Lys metalloendopeptidase"
RHEA:52883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:59829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-inosyl-L-homocysteine => inosine + L-homocysteine
RHEA:22443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP
REACT:R-SSC-390835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD1,5 bind DA (Sus scrofa)
REACT:R-HSA-2172183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB (Homo sapiens)
GO:0102717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIBOA-glucoside oxygenase activity
REACT:R-SSC-6792863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PP2R5C dephosphorylates MDM2 (Sus scrofa)
RHEA:31889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tirucalladienol => (S)-2,3-epoxysqualene
RHEA:63373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + L-cysteinyl-[protein] => an S-acyl-L-cysteinyl-[protein] + CoA
GO:0050557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylipecoside synthase activity
GO:0050557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetylipecoside dopamine-lyase (secologanin-forming)
GO:0050557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deacetylipecoside dopamine-lyase activity
REACT:R-SSC-9020282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Sus scrofa)
REACT:R-DDI-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Dictyostelium discoideum)
REACT:R-BTA-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Bos taurus)
REACT:R-RNO-8852010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL2 binds activated T cells surface (Rattus norvegicus)
RHEA:36496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + ATP => ADP + alpha-D-glucose 6-phosphate + H(+)
REACT:R-GGA-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Gallus gallus)
REACT:R-DRE-2559456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIRAP binds PIP2-rich regions in the plasma membrane (Danio rerio)
REACT:R-SSC-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Sus scrofa)
REACT:R-MMU-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Mus musculus)
REACT:R-CEL-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Caenorhabditis elegans)
REACT:R-CFA-2730844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GRB2:SOS complex with p-SHC1 (Canis familiaris)
REACT:R-CFA-5357831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD is phosphorylated by IKK (Canis familiaris)
REACT:R-RNO-3371359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)
RHEA:28262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase"
RHEA:28262	skos:altLabel	"XPT1"
RHEA:28262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose = 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP
RHEA:28262	skos:prefLabel	"3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase"
REACT:R-DME-9668902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18-RFC(7s) complex (Drosophila melanogaster)
RHEA:58972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + vanillin = H(+) + H2O2 + vanillate
GO:0016409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylation of eNOS (Homo sapiens)
GO:0016409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyltransferase activity
GO:0016409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Homo sapiens)
RHEA:11794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-epoxypropane + H2O + NAD(+) => H(+) + NADH + O2 + propene
RHEA:64066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2R)-pseudoephedrine + NAD(+)
GO:0031783	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 5 melanocortin receptor ligand
GO:0031783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 5 melanocortin receptor binding
GO:0004306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:phosphoethanolamine cytidylyltransferase activity
GO:0004306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine-phosphate cytidylyltransferase activity
GO:0004306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoethanolamine cytidylyltransferase activity
GO:0004306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ET
GO:0004306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP-phosphoethanolamine cytidylyltransferase activity
GO:0004306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:ethanolamine-phosphate cytidylyltransferase activity
GO:0004306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ethanolamine phosphate cytidylyltransferase activity
GO:0004306	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphorylethanolamine transferase activity
RHEA:64402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-amino acid tripeptide(in) + H(+)(in) => an L-amino acid tripeptide(out) + H(+)(out)
RHEA:61147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin + UDP-beta-L-rhamnose <=> H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP
RHEA:55891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[aequorin]--dioxetanone <=> [excited state blue fluorescent protein] + CO2
REACT:R-RNO-376357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp7 associated Lysosome to Plasma membrane transport (Rattus norvegicus)
REACT:R-SPO-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Schizosaccharomyces pombe)
GO:0047808	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-tartrate dehydratase activity
GO:0047808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D(-)-tartrate dehydratase activity
GO:0047808	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S,S)-tartrate hydro-lyase (oxaloacetate-forming)
GO:0047808	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S,S)-tartrate hydro-lyase activity
REACT:R-DRE-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Danio rerio)
REACT:R-DME-1524182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLC gamma dissociates from the PDGF receptor (Drosophila melanogaster)
REACT:R-DRE-1297275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD9:Izumo Binding (Danio rerio)
REACT:R-HSA-9731228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)
REACT:R-DRE-209772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to triiodothyronine (Danio rerio)
REACT:R-DME-354289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene (Drosophila melanogaster)
REACT:R-RNO-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Rattus norvegicus)
REACT:R-DRE-1474210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP14 (Danio rerio)
REACT:R-SSC-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Sus scrofa)
RHEA:14932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADH
REACT:R-SPO-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Schizosaccharomyces pombe)
REACT:R-DME-5622134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRABP1 binds atRA (Drosophila melanogaster)
REACT:R-HSA-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Homo sapiens)
GO:0047275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity
GO:0047275	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity
GO:0047275	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GalT-4
GO:0047275	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	paragloboside synthase activity
GO:0047275	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity
GO:0047275	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity
RHEA:22184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH
RHEA:22184	skos:prefLabel	"trans-acenaphthene-1,2-diol dehydrogenase"
RHEA:22184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-acenaphthene-1,2-diol dehydrogenase"
REACT:R-SPO-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)
REACT:R-XTR-159752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Xenopus tropicalis)
RHEA:26390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + O2 => all-trans-10'-apo-beta-carotenal + beta-ionone
REACT:R-SPO-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Schizosaccharomyces pombe)
GO:0015649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-keto-3-deoxygluconate:hydrogen symporter activity
GO:0015649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) = 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)
GO:0015649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-keto-3-deoxygluconate:proton symporter activity
REACT:R-SSC-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Sus scrofa)
REACT:R-HSA-159358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A3,4 dimers sulfate DA to DAOS (Homo sapiens)
RHEA:59673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotriose + O2 => D-maltotriono-1,5-lactone + H2O2
RHEA:16500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-GGA-5635845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind CDC73 (Gallus gallus)
RHEA:26162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thalianol => (S)-2,3-epoxysqualene
REACT:R-HSA-2976716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 coactivator complex binds HES1 promoter (Homo sapiens)
RHEA:21828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:21828	skos:prefLabel	"ferredoxin--nitrate reductase"
RHEA:21828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin--nitrate reductase"
RHEA:21828	skos:altLabel	"assimilatory nitrate reductase"
RHEA:39514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O
RHEA:41853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + octanoyl-[ACP] => 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-DDI-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Dictyostelium discoideum)
REACT:R-SPO-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Schizosaccharomyces pombe)
RHEA:47454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(5Z-tetradecenoyl)-CoA => (2E,5Z)-tetradecadienoyl-CoA + H2O
REACT:R-MMU-2468287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
REACT:R-GGA-2514790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by MMP14 (Gallus gallus)
RHEA:60274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine
RHEA:41113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O
RHEA:31686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prosolanapyrone III <=> (-)-solanapyrone A
GO:0047283	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity
GO:0047283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-phosphate D-xylosyltransferase activity
REACT:R-MMU-193508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Mus musculus)
RHEA:69435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine <=> 3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine
REACT:R-XTR-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Xenopus tropicalis)
REACT:R-SCE-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Saccharomyces cerevisiae)
RHEA:62008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)
RHEA:22738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + NH4(+) => 5-formimidoyltetrahydrofolate + 2 H(+)
RHEA:59228	skos:prefLabel	"sulfoquinovose mutarotase"
RHEA:59228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfoquinovose mutarotase"
RHEA:59228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-alpha-D-quinovose = 6-sulfo-beta-D-quinovose
REACT:R-HSA-6792863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
RHEA:71939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + 3 Na(+)(out) = 2-oxoglutarate(in) + 3 Na(+)(in)
RHEA:41454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+) => 5-methyl-1-naphthoate + H(+) + NADPH + O2
REACT:R-HSA-167408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The high affinity receptor complex binds to G-protein (Homo sapiens)
REACT:R-RNO-8982617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB:O2 dissociates (Rattus norvegicus)
GO:0019864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgG binding
REACT:R-CFA-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Canis familiaris)
RHEA:68286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-hexanoyl-L-seryl-[protein] => hexanoyl-CoA + L-seryl-[protein]
RHEA:42923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(1498) in 16S rRNA <=> H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine
REACT:R-DME-75886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Drosophila melanogaster)
RHEA:55929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-349603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Drosophila melanogaster)
RHEA:55851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA
RHEA:71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhispidin + O2 <=> (E)-caffeoylpyruvate + CO2 + hnu
RHEA:12762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-3B + S-adenosyl-L-methionine => 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine
REACT:R-RNO-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Rattus norvegicus)
RHEA:59827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + pyridoxamine 5'-phosphate <=> L-glutamate + pyridoxal 5'-phosphate
RHEA:72831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP + H2O = G[3'-5']pAp[3'] + H(+)
RHEA:67011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine
RHEA:63704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP
REACT:R-MMU-9027302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Mus musculus)
REACT:R-XTR-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Xenopus tropicalis)
RHEA:22034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + oxaloacetate => 3-oxalomalate
REACT:R-DRE-5205649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 links damaged mitochondria to LC3 (Danio rerio)
REACT:R-DDI-83788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to Type 2 promoter (Dictyostelium discoideum)
RHEA:50620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:50620	skos:prefLabel	"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase"
RHEA:50620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase"
GO:0080004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thalian-diol desaturase activity
RHEA:65876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androst-1-ene-3,17-dione + H2O = 1-hydroxy-5alpha-androstan-3,17-dione
GO:0004764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-dehydroshikimate reductase activity
GO:0004764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-dehydroshikimic reductase activity
GO:0004764	skos:altLabel	"5-dehydroshikimic reductase"
GO:0004764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	shikimate 3-dehydrogenase (NADP+) activity
GO:0004764	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DHS reductase activity
GO:0004764	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	shikimate:NADP(+) 5-oxidoreductase activity
GO:0004764	skos:altLabel	"shikimate dehydrogenase"
GO:0004764	skos:altLabel	"5-dehydroshikimate reductase"
GO:0004764	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	shikimate:NADP(+) oxidoreductase activity
GO:0004764	skos:altLabel	"DHS reductase"
GO:0004764	skos:altLabel	"shikimate oxidoreductase"
GO:0004764	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	shikimate oxidoreductase activity
GO:0004764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"shikimate dehydrogenase (NADP(+))"
GO:0004764	skos:altLabel	"dehydroshikimic reductase"
GO:0004764	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dehydroshikimic reductase activity
GO:0004764	skos:altLabel	"shikimate 5-dehydrogenase"
GO:0004764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH
GO:0004764	skos:prefLabel	"shikimate dehydrogenase (NADP(+))"
RHEA:25343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + urea => carbamate + NH4(+)
REACT:R-BTA-4568863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RAD52 with SUMO1 (Bos taurus)
REACT:R-GGA-433823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Released NFkB complex migrates to the nucleus and turns on transcription (Gallus gallus)
REACT:R-GGA-6810239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)
REACT:R-RNO-3215385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Rattus norvegicus)
REACT:R-HSA-3296462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CUBN does not transport GIF:Cbl (Homo sapiens)
REACT:R-DDI-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Dictyostelium discoideum)
RHEA:53048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-HSA-6791302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the AIFM2 gene promoter (Homo sapiens)
RHEA:49196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:21694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + 2 H(+) + sn-glycerol 3-phosphate => CDP-glycerol + H2O
GO:0033732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PqqC
GO:0033732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrroloquinoline-quinone synthase activity
GO:0033732	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity
RHEA:34851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxyadipyl-CoA + NAD(+) = 3-oxoadipyl-CoA + H(+) + NADH
RHEA:62912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toralactone = 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)
RHEA:51371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylglycine
REACT:R-RNO-4546385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO2 (Rattus norvegicus)
REACT:R-BTA-9025957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Bos taurus)
REACT:R-RNO-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Rattus norvegicus)
RHEA:67460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate + A = AH2 + oxaloacetate
RHEA:10503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + glyoxylate + H2O <=> 3-ethylmalate + CoA + H(+)
REACT:R-BTA-5693575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PKcs autophosphorylates (Bos taurus)
REACT:R-SCE-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)
RHEA:10896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + limonin = 2 H(+) + limonoate
RHEA:10896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limonin-D-ring-lactonase"
RHEA:10896	skos:prefLabel	"limonin-D-ring-lactonase"
REACT:R-HSA-2161962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydrolysed to 6t-/6t,12epi-LTB4 (Homo sapiens)
RHEA:41109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O
REACT:R-SSC-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Sus scrofa)
REACT:R-BTA-352182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Bos taurus)
REACT:R-SSC-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Sus scrofa)
REACT:R-GGA-202203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PI3K to plasma membrane (Gallus gallus)
RHEA:71234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(3+)-[Dph3] + NADH <=> 2 Fe(2+)-[Dph3] + H(+) + NAD(+)
REACT:R-DRE-9670014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor VIIIa dissociates  (Danio rerio)
RHEA:50276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate
RHEA:49464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-resorcylate decarboxylase"
RHEA:49464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxybenzoate + H(+) = CO2 + resorcinol
RHEA:49464	skos:prefLabel	"gamma-resorcylate decarboxylase"
GO:0050564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alpha-aminoadipyl-cysteinyl-valine synthetase activity
GO:0050564	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ACV synthetase activity
GO:0050564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)
GO:0050564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity
GO:0050564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity
REACT:R-CFA-1606564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Canis familiaris)
REACT:R-HSA-8854897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Homo sapiens)
REACT:R-MMU-981809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Mus musculus)
REACT:R-SSC-9632182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates ESRs (Sus scrofa)
REACT:R-HSA-6791228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)
REACT:R-DRE-76456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-atom dealkylation of dextromethorphan (Danio rerio)
RHEA:65833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate
REACT:R-SPO-5324632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Schizosaccharomyces pombe)
REACT:R-CFA-5666008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCAI binds SRF:MKL1 (Canis familiaris)
REACT:R-CEL-352385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Caenorhabditis elegans)
REACT:R-DME-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Drosophila melanogaster)
REACT:R-BTA-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Bos taurus)
REACT:R-RNO-391942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP receptor can bind prostacyclin (Rattus norvegicus)
REACT:R-DME-8857662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Drosophila melanogaster)
RHEA:71034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(in) + L-phenylalanine(out) <=> L-cysteine(out) + L-phenylalanine(in)
REACT:R-HSA-6784494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EKC complex threonylcarbamoylates A37 of tRNAs (Homo sapiens)
REACT:R-BTA-9027532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DHA to 13-HDHA (Bos taurus)
REACT:R-CEL-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
REACT:R-GGA-8940959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurolysin degrades neurotensin (Gallus gallus)
RHEA:54616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + heptadecanoyl-CoA + O2 = 2-hydroxyheptadecanoyl-CoA + CO2 + succinate
REACT:R-PFA-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Plasmodium falciparum)
RHEA:15201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine
RHEA:15201	skos:prefLabel	"6-hydroxymellein O-methyltransferase"
RHEA:15201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-hydroxymellein O-methyltransferase"
RHEA:11733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B => H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]
RHEA:54177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + holo-[ACP] + NADP(+) => a long-chain fatty acyl-[ACP] + H(+) + NADPH
REACT:R-HSA-2328145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminin-111 binds collagen type IV (Homo sapiens)
REACT:R-DRE-419646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:Met (Danio rerio)
RHEA:45061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl) ethanolamine => (9Z)-octadecenoate + ethanolamine
RHEA:48890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione
RHEA:28581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(2+)(in) <=> Co(2+)(out)
REACT:R-RNO-1247497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds neuregulins (Rattus norvegicus)
GO:0047929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-gluconate hydro-lyase activity
GO:0047929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)
GO:0047929	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-gluconate dehydratase activity
GO:0047929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gluconate dehydratase activity
REACT:R-MMU-1168635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (PKC-beta) phosphorylates CARMA1 (Mus musculus)
REACT:R-DRE-8987266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Danio rerio)
RHEA:68421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-(homo)3aconitate + H2O => (2R,3S)-iso(homo)3citrate
REACT:R-CFA-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Canis familiaris)
RHEA:58814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
RHEA:17872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydropteridine + NAD(+) <=> 6,7-dihydropteridine + H(+) + NADH
REACT:R-DRE-2161795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Danio rerio)
REACT:R-XTR-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Xenopus tropicalis)
REACT:R-XTR-8876312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Xenopus tropicalis)
RHEA:41489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine
GO:0004329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrofolic formylase activity
GO:0004329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrofolate formylase activity
GO:0004329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyltetrahydrofolate synthetase activity
GO:0004329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate-tetrahydrofolate ligase activity
GO:0004329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyl-THF synthetase activity
GO:0004329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyltetrahydrofolate synthetase activity
GO:0004329	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate:tetrahydrofolate ligase (ADP-forming)
GO:0047398	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity
GO:0047398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichylphosphate-mannose phosphodiesterase activity
GO:0047398	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosylphosphodolichol phosphodiesterase activity
REACT:R-DRE-158218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Danio rerio)
REACT:R-RNO-1602473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP1 (Rattus norvegicus)
RHEA:42444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NADP(+) = H(+) + iminosuccinate + NADPH
GO:0016761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity
GO:0016761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-glucose-beta-D-glucan glucosyltransferase activity
GO:0016761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity
GO:0016761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity
GO:0016761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-glucose-cellulose glucosyltransferase activity
GO:0016761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphoglucose-cellulose glucosyltransferase activity
GO:0016761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellulose synthase (guanosine diphosphate-forming) activity
GO:0016761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellulose synthase (GDP-forming) activity
REACT:R-HSA-9617596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP (Homo sapiens)
RHEA:36015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-HSA-351229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylated spermine (cytosol)=>N-acetylated spermine (peroxisomal) (Homo sapiens)
REACT:R-GGA-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Gallus gallus)
REACT:R-BTA-9020273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Bos taurus)
RHEA:26087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + limonene 1,2-epoxide + NADP(+) => (4S)-limonene + H(+) + NADPH + O2
RHEA:56449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
GO:0047417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-carbamoyl-D-amino-acid hydrolase"
GO:0047417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-carbamoyl-D-amino acid hydrolase activity
GO:0047417	skos:altLabel	"D-N-carbamoylase"
GO:0047417	skos:altLabel	"N-carbamoylase"
GO:0047417	skos:prefLabel	"N-carbamoyl-D-amino-acid hydrolase"
GO:0047417	skos:altLabel	"N-carbamoyl-D-amino acid hydrolase"
GO:0047417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-carbamoyl-D-amino acid + 2 H(+) + H2O = a D-alpha-amino acid + CO2 + NH4(+)
GO:0047417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-carbamoyl-D-amino acid amidohydrolase activity
REACT:R-CFA-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
EC:6.3.2.11	skos:altLabel	"carnosine synthetase"
EC:6.3.2.11	skos:prefLabel	"carnosine synthase"
EC:6.3.2.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnosine synthase"
REACT:R-CEL-8953037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F8 forms homodimers (Caenorhabditis elegans)
REACT:R-SPO-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Schizosaccharomyces pombe)
REACT:R-XTR-372480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Xenopus tropicalis)
REACT:R-DME-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Drosophila melanogaster)
RHEA:65672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine
REACT:R-DRE-2466106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BGN binds Collagen types I, VI, (IX) (Danio rerio)
RHEA:57855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase
REACT:R-BTA-6809707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTMR2 (Bos taurus)
RHEA:36615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine
RHEA:57533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-RNA + ATP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate
RHEA:62268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-3-methylbutyrate + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH
RHEA:63055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol
REACT:R-HSA-6795460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK1 phosphorylates MDM2 (Homo sapiens)
RHEA:31019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 = 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O
RHEA:31019	skos:prefLabel	"diapolycopene oxygenase"
RHEA:31019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diapolycopene oxygenase"
RHEA:32553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O
REACT:R-HSA-1181351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEFTY binds the EGF-CFC coreceptor in the NODAL receptor (Homo sapiens)
RHEA:37115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-sphing-4-enine
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aminoacylase I activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acylase I activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzamidase activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histozyme activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amido acid deacylase activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-amino-acid acylase activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hippurase activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long acyl amidoacylase activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacylase activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-L-amino-acid amidohydrolase activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dehydropeptidase II activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aminoacylase activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short acyl amidoacylase activity
GO:0004046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-acylaminoacid hydrolase activity
REACT:R-HSA-5334788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUTC binds Cu+ (Homo sapiens)
REACT:R-RNO-9668023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to FVIII (Rattus norvegicus)
RHEA:19221	skos:prefLabel	"formaldehyde dismutase"
RHEA:19221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 formaldehyde + H2O = formate + H(+) + methanol
RHEA:19221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formaldehyde dismutase"
REACT:R-MMU-1655831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 translocates to the nucleus (Mus musculus)
REACT:R-DRE-9008271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Danio rerio)
RHEA:36441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O
RHEA:68889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxybenzoate + ATP + H(+) + NADPH => 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)
REACT:R-CFA-5649701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Canis familiaris)
REACT:R-XTR-5686286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Xenopus tropicalis)
REACT:R-DME-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)
RHEA:22391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N(6)-hydroxy-L-lysine <=> CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine
GO:0102140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan sulfate N-deacetylase activity
REACT:R-HSA-9033515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves ACOX1 (Homo sapiens)
REACT:R-GGA-8944246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXI (Gallus gallus)
RHEA:19958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5'-dehydroinosine + O2 => 2 9-riburonosylhypoxanthine + 2 H(+)
RHEA:72874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A3 + malonyl-CoA <=> anthocyanin A5 + CoA
RHEA:69610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-[tubulin] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]
REACT:R-MMU-173740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to C3(H2O) (Mus musculus)
RHEA:22302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucoside + H(+) + UDP => a flavonol + UDP-alpha-D-glucose
RHEA:47319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-DDI-8951764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2F (Dictyostelium discoideum)
REACT:R-DRE-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Danio rerio)
RHEA:48567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-ribosyl-trans-zeatin 5'-phosphate + H2O <=> D-ribose 5-phosphate + trans-zeatin
REACT:R-HSA-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Homo sapiens)
REACT:R-DME-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)
GO:0102629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	patuletin 3'-O-methyltransferase activity
REACT:R-HSA-9698007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 ITD mutants bind STAT5 through GAB2:PTPN11 (Homo sapiens)
REACT:R-BTA-2990842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO2 (Bos taurus)
RHEA:21087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin 4'-sulfate <=> dermatan 4'-sulfate
REACT:R-CFA-417890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y5 receptor can bind to LPA (Canis familiaris)
REACT:R-HSA-9694656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike trimer glycoside chains are extended (Homo sapiens)
REACT:R-BTA-5662613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 exchanges zinc for copper (Bos taurus)
REACT:R-BTA-976768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3b (Bos taurus)
REACT:R-HSA-140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequestered tissue factor -> tissue factor (Homo sapiens)
REACT:R-HSA-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
REACT:R-HSA-2033476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)
REACT:R-DDI-9018859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Dictyostelium discoideum)
RHEA:67409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol
RHEA:72043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + orotate(out) = L-glutamate(out) + orotate(in)
REACT:R-RNO-351849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Etk (Rattus norvegicus)
REACT:R-HSA-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Homo sapiens)
REACT:R-DDI-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)
REACT:R-HSA-9625092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA6 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
REACT:R-GGA-9634702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Gallus gallus)
RHEA:13433	skos:prefLabel	"cytidine deaminase"
RHEA:13433	skos:altLabel	"cytidine aminohydrolase"
RHEA:13433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + H(+) + H2O = NH4(+) + uridine
RHEA:13433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)
RHEA:13433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytidine deaminase"
RHEA:13433	skos:altLabel	"(deoxy)cytidine deaminase"
RHEA:13433	skos:altLabel	"cytosine nucleoside deaminase"
REACT:R-RNO-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Rattus norvegicus)
RHEA:15772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+)
GO:0018651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toluene-4-sulphonate monooxygenase activity
GO:0018651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toluene-4-sulfonate monooxygenase activity
RHEA:70828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-lysine(out) => L-arginine(out) + L-lysine(in)
REACT:R-CFA-5218822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK binds BCAR1 and or PXN (Canis familiaris)
GO:0043909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylcitrulline deacetylase activity
GO:0043909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-citrulline deacetylase activity
GO:0043909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcitrulline deacetylase activity
GO:0043909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline
RHEA:44042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O
RHEA:67088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + tetracosanoate(in) = ADP + H(+) + phosphate + tetracosanoate(out)
RHEA:56674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + H(+) + NADPH => dihydro-4-coumaroyl-CoA + NADP(+)
RHEA:42954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA + S-adenosyl-L-methionine
RHEA:30818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + H2O <=> beta-nicotinamide D-riboside + phosphate
REACT:R-BTA-5423117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates MeK21-histone H4 (Bos taurus)
REACT:R-BTA-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Bos taurus)
RHEA:16020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ornithine <=> 5-amino-2-oxopentanoate + L-glutamate
RHEA:35105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fusidate(out) => fusidate(in)
RHEA:71729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + fumarate(out) => citrate(out) + fumarate(in)
RHEA:72113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in) => L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out)
REACT:R-CFA-6806732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY binds the bacterial cell surface (Canis familiaris)
REACT:R-RNO-9708859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Rattus norvegicus)
REACT:R-RNO-1638104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Rattus norvegicus)
REACT:R-SCE-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Saccharomyces cerevisiae)
REACT:R-SPO-353125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteosome degrades ODC holoenzyme complex (Schizosaccharomyces pombe)
RHEA:40517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate => 6-deoxy-6-sulfo-D-fructose 1-phosphate
REACT:R-DRE-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Danio rerio)
REACT:R-CEL-6810392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMEM55B translocates to the nucleus (Caenorhabditis elegans)
REACT:R-CFA-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)
RHEA:21202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + L-glutamate => 2-oxoglutarate + L-lysine
REACT:R-CFA-8876319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC50A1 transports Glc from cytosol to extracellular region (Canis familiaris)
REACT:R-GGA-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Gallus gallus)
REACT:R-MMU-8851859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds RANBP9 and SOS1 (Mus musculus)
REACT:R-RNO-5654169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 (Rattus norvegicus)
GO:0140620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA strand exchange inhibitor activity
RHEA:39085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + decanedioyl-CoA => 3-oxododecanedioyl-CoA + CoA
REACT:R-BTA-372705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of BCAR1 to PTK2 complex (Bos taurus)
REACT:R-RNO-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Rattus norvegicus)
REACT:R-MMU-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Mus musculus)
RHEA:19078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate
RHEA:50293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:53402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
REACT:R-HSA-744886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
REACT:R-DME-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Drosophila melanogaster)
RHEA:60106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein] => 3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:43527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allo-threonine + NADP(+) <=> aminoacetone + CO2 + NADPH
RHEA:61368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate
REACT:R-DME-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Drosophila melanogaster)
RHEA:46269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SSC-5218851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Sus scrofa)
REACT:R-SSC-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Sus scrofa)
REACT:R-BTA-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)
GO:0004657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline dehydrogenase activity
GO:0004657	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-proline dehydrogenase activity
REACT:R-SPO-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Schizosaccharomyces pombe)
REACT:R-BTA-83656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Bos taurus)
REACT:R-CEL-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Caenorhabditis elegans)
RHEA:28267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (S)-beta-bisabolene + diphosphate
GO:0008379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin peroxidase activity
GO:0008379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPx activity
GO:0008379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TrxPx activity
GO:0008379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN2 (Homo sapiens)
GO:0008379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiol peroxidase activity
REACT:R-SSC-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Sus scrofa)
GO:1990699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoleyl hydrolase activity
REACT:R-GGA-177944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)
GO:0002055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine binding
GO:0002055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-aminopurine binding
RHEA:34167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,6-dihydroxypseudooxynicotine hydrolase"
RHEA:34167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)
RHEA:34167	skos:prefLabel	"2,6-dihydroxypseudooxynicotine hydrolase"
REACT:R-CFA-5694487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A4GNT transfers GlcNAc to core 2 mucins (Canis familiaris)
RHEA:14286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP
RHEA:41406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-1-pyrroline + H(+) + NADPH => (R)-2-methylpyrrolidine + NADP(+)
REACT:R-HSA-444773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-TM7 receptors bind chondroitin sulphate (Homo sapiens)
RHEA:65353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O
GO:0046423	skos:prefLabel	"allene-oxide cyclase"
GO:0046423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"allene-oxide cyclase"
GO:0046423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allene-oxide cyclase activity
GO:0046423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (10Z,15Z)-12-oxophytodienoate
GO:0046423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing)
RHEA:12014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + thiamine phosphate => ATP + thiamine
REACT:R-CFA-5688276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT4 transfers ADPRib to GLUD (Canis familiaris)
REACT:R-PFA-5687088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates MAPKAPK5 (Plasmodium falciparum)
RHEA:42787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine
RHEA:72741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out)
RHEA:11684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine
RHEA:14196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + AH2 + O2 <=> 2,3-dihydroxybenzoate + A + H2O
REACT:R-HSA-1028817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Homo sapiens)
RHEA:23589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate + succinyl-CoA => oxalyl-CoA + succinate
RHEA:14633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Na(+)(in) = ADP + H(+) + Na(+)(out) + phosphate
RHEA:70078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine
REACT:R-HSA-8949661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Homo sapiens)
RHEA:50742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + leukotriene F4 => H2O + leukotriene C4
REACT:R-CEL-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Caenorhabditis elegans)
RHEA:72964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(out) + 2 Na(+)(out) => acetoacetate(in) + 2 Na(+)(in)
REACT:R-HSA-8982640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Homo sapiens)
RHEA:61180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucoside + UDP
REACT:R-XTR-9610750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Xenopus tropicalis)
RHEA:51600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:45456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoylethanolamine = dodecanoate + ethanolamine
RHEA:32760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine => (3R)-3-methyl-D-ornithine
REACT:R-GGA-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Gallus gallus)
REACT:R-GGA-202704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaXbeta2 binds JAM3 (Gallus gallus)
RHEA:22736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formimidoyltetrahydrofolate cyclodeaminase"
RHEA:22736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH4(+)
RHEA:22736	skos:altLabel	"formiminotetrahydrofolate cyclodeaminase"
RHEA:22736	skos:prefLabel	"formimidoyltetrahydrofolate cyclodeaminase"
REACT:R-GGA-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Gallus gallus)
RHEA:31299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + perillyl aldehyde = 2 H(+) + NADH + perillate
RHEA:38001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine
REACT:R-CFA-2201338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds TICAM1:activated TLR4 complex (Canis familiaris)
REACT:R-HSA-9700647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates SRC (Homo sapiens)
RHEA:17764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic primary alcohol + NADP(+) <=> an aromatic aldehyde + H(+) + NADPH
REACT:R-DRE-2172433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIX degradation (Danio rerio)
REACT:R-XTR-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Xenopus tropicalis)
REACT:R-HSA-1675866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane (Homo sapiens)
RHEA:69876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:47449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0052788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	d-4,5 unsaturated beta-glucuronyl hydrolase activity
GO:0052788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	unsaturated beta-glucuronyl hydrolase activity
GO:0047570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity
GO:0047570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate enol-lactonase activity
GO:0047570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoadipic enol-lactone hydrolase activity
GO:0047570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxymethylbutenolide lactonase activity
GO:0047570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxoadipic enol-lactone hydrolase activity
GO:0047570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketoadipate enol-lactonase activity
GO:0047570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-ketoadipate enol-lactone hydrolase activity
GO:0047254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity
GO:0047254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity
GO:0047254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity
GO:0047254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity
GO:0052606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a oxygenase activity
GO:0052606	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorophyllide-a oxygenase activity
GO:0052606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a oxygenase activity
GO:0052606	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	CAO activity
GO:0052606	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorophyllide a:oxygen 7-oxidoreductase activity
REACT:R-DRE-2981040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC12:ligand is endocytosed (Danio rerio)
RHEA:38355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phenyllactoyl-CoA = (E)-cinnamoyl-CoA + H2O
RHEA:28409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XTP <=> H(+) + phosphate + XDP
REACT:R-RNO-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Rattus norvegicus)
RHEA:17222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O
REACT:R-CFA-8875523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS3 (Canis familiaris)
REACT:R-CEL-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Caenorhabditis elegans)
REACT:R-RNO-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Rattus norvegicus)
RHEA:59650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotrionate + H(+) => D-xylotriono-1,5-lactone + H2O
REACT:R-RNO-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
RHEA:17085	skos:prefLabel	"4-pyridoxate dehydrogenase"
RHEA:17085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-pyridoxate dehydrogenase"
RHEA:17085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxate + A = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2
RHEA:12870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (4S)-limonene + diphosphate
RHEA:40327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-GGA-5654167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds PLCG1 (Gallus gallus)
RHEA:49257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]
REACT:R-HSA-5432852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)
RHEA:10051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanethiol + O-acetyl-L-homoserine <=> acetate + H(+) + L-methionine
REACT:R-RNO-5686398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPIDR binds BLM:TOP3A:RMI1:RMI2 (Rattus norvegicus)
RHEA:21217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)
RHEA:50722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + H(+) + H2O + methanesulfonate => FMNH2 + methanesulfinate + O2
GO:0031732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIP-3 beta receptor binding
GO:0031732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR7 chemokine receptor binding
GO:0031732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 EBV-induced G-protein coupled receptor binding
GO:0031732	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR7 chemokine receptor ligand
REACT:R-RNO-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-MMU-8849882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-4 bind reticulon 3 (Mus musculus)
RHEA:67111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine
RHEA:57329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]
RHEA:50726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(4-hydroxyphenyl)acetaldehyde oxime => (E)-4-hydroxyphenylacetaldehyde oxime
REACT:R-MMU-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Mus musculus)
REACT:R-BTA-216076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Bos taurus)
REACT:R-RNO-83656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Rattus norvegicus)
REACT:R-SSC-452108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Sus scrofa)
REACT:R-HSA-2213248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
REACT:R-RNO-8940074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NMN (Rattus norvegicus)
REACT:R-BTA-8877311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB31 GEFs exchange GTP for GDP on RAB31 (Bos taurus)
REACT:R-BTA-6791221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Bos taurus)
REACT:R-CEL-450490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B/Akt phosphorylates BRF1 (Caenorhabditis elegans)
REACT:R-DME-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Drosophila melanogaster)
RHEA:51723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)
RHEA:45752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-decenoyl-CoA = (2E)-decenoyl-CoA
REACT:R-DME-1482695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Drosophila melanogaster)
RHEA:24936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + imidazol-4-one => N-formimidoylglycine
REACT:R-CEL-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)
RHEA:38238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + octadecan-1-ol <=> 1-O-octadecyl (9Z)-octadecenoate + CoA
RHEA:18584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine + H2O + O2 <=> glycolaldehyde + H2O2 + NH4(+)
REACT:R-GGA-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Gallus gallus)
RHEA:46727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methyltetradecanoyl-CoA <=> (2R)-2-methyltetradecanoyl-CoA
REACT:R-CFA-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Canis familiaris)
RHEA:67639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-2'-deoxyadenylo-succinate <=> dZMP + fumarate
REACT:R-HSA-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Homo sapiens)
REACT:R-GGA-5693578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDP1 and TDP2 process unligatable DSB ends (Gallus gallus)
RHEA:46141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-6809263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Danio rerio)
REACT:R-CEL-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Caenorhabditis elegans)
RHEA:46810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine => [trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine
REACT:R-PFA-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)
RHEA:65983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hnu + previtamin D3 <=> tachysterol 3
RHEA:25658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-menthofuran synthase"
RHEA:25658	skos:altLabel	"(+)-MFS"
RHEA:25658	skos:altLabel	"menthofuran synthase"
RHEA:25658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] = (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:25658	skos:prefLabel	"(+)-menthofuran synthase"
RHEA:25658	skos:altLabel	"(+)-pulegone 9-hydroxylase"
REACT:R-BTA-997311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of TYK2 by PTP1B (Bos taurus)
REACT:R-DME-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Drosophila melanogaster)
RHEA:50397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA => 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O
REACT:R-XTR-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Xenopus tropicalis)
REACT:R-DRE-9708536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 translocates from the cytosol to the nucleoplasm (Danio rerio)
RHEA:36834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 caldariellaquinol + n H(+)(in) + O2 <=> 2 caldariellaquinone + n H(+)(out) + 2 H2O
REACT:R-HSA-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Homo sapiens)
REACT:R-GGA-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Gallus gallus)
REACT:R-BTA-74716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin binds the insulin receptor (Bos taurus)
REACT:R-DRE-183089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)
RHEA:69414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + H2O + tert-butanol => 2 glutathione + tert-butyl hydroperoxide
REACT:R-CFA-8866304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL binds lipids to form VLDL (Canis familiaris)
RHEA:51820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + decanoate(out) + H(+)(out) = AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)
REACT:R-DME-177479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Axonal transport of NGF:Trk complexes (Drosophila melanogaster)
REACT:R-DRE-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Danio rerio)
RHEA:71347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-lysine(out) + 2 Na(+)(out) = chloride(in) + L-lysine(in) + 2 Na(+)(in)
GO:0036134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin H2 degradation activity
GO:0036134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyheptadecatrienoic acid synthase activity
REACT:R-BTA-5607726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
RHEA:66770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + coproporphyrin I(out) + H(+) + phosphate => ATP + coproporphyrin I(in) + H2O
REACT:R-PFA-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Plasmodium falciparum)
RHEA:31876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => marneral
REACT:R-XTR-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Xenopus tropicalis)
RHEA:43274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD2 + H(+) + UDP => ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-HSA-2201293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TLR4:LY96:LPS:CD14 (Homo sapiens)
REACT:R-CEL-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Caenorhabditis elegans)
REACT:R-DME-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Drosophila melanogaster)
REACT:R-MMU-176585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Mus musculus)
REACT:R-CFA-8852874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 binds C3d, C3dg, iC3b (Canis familiaris)
RHEA:39806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH
REACT:R-DRE-5683967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Danio rerio)
REACT:R-HSA-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Homo sapiens)
REACT:R-GGA-174238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Gallus gallus)
REACT:R-SSC-1250315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB4 homodimers (Sus scrofa)
RHEA:10209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)
REACT:R-BTA-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Bos taurus)
RHEA:28151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + spermidine => CoA + H(+) + N(1)-acetylspermidine
RHEA:43401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascorbic free radical reductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monodehydroascorbate reductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MDHA
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:monodehydroascorbate oxidoreductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascorbate free-radical reductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AFR-reductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:AFR oxidoreductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-semidehydroascorbate oxidoreductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MDAsA reductase (NADPH)
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	semidehydroascorbate reductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monodehydroascorbate reductase (NADH) activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SDA reductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AFR
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascorbate free radical reductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:ascorbate radical oxidoreductase activity
GO:0016656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:semidehydroascorbic acid oxidoreductase activity
RHEA:11853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + S-methyl-5'-thioadenosine => adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
RHEA:13653	skos:prefLabel	"levansucrase"
RHEA:13653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose = [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose
RHEA:13653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"levansucrase"
RHEA:13653	skos:altLabel	"sucrose 6-fructosyltransferase"
GO:0106099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-keto-3-deoxy-L-rhamnonate aldolase activity
GO:0106099	skos:altLabel	"2-keto-3-deoxy acid sugar aldolase"
GO:0106099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate
GO:0106099	skos:altLabel	"KDR aldolase"
GO:0106099	skos:altLabel	"2-dehydro-3-deoxyrhamnonate aldolase"
GO:0106099	skos:prefLabel	"2-keto-3-deoxy-L-rhamnonate aldolase"
GO:0106099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-keto-3-deoxy-L-rhamnonate aldolase"
REACT:R-GGA-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)
RHEA:54507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-hexaprenyl diphosphate <=> beta-hexaprene + diphosphate
REACT:R-HSA-6800120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene (Homo sapiens)
REACT:R-HSA-9698962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of pPR-AP to pAP to form the pPR-AP:pAP Complex (Homo sapiens)
REACT:R-SSC-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)
GO:0070457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose-1-phosphate phosphatase activity
GO:0047286	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ADP-ribosyltransferase activity
GO:0047286	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	mono(ADP-ribosyl)transferase activity
GO:0047286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-diphthamide ADP-ribosyltransferase activity
GO:0047286	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity
GO:0047286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-diphthamide ADP-ribosyltransferase activity
REACT:R-MMU-5661117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Mus musculus)
RHEA:71685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + L-aspartyl-glycine(in) => 2 H(+)(out) + L-aspartyl-glycine(out)
REACT:R-SPO-3108212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Schizosaccharomyces pombe)
REACT:R-RNO-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Rattus norvegicus)
REACT:R-MMU-450133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP binds MYD88 homodimer (Mus musculus)
RHEA:38845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine
REACT:R-SSC-3002811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates PLK1 (Sus scrofa)
REACT:R-MMU-5662986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds copper (Mus musculus)
GO:0140517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-RNA adaptor activity
REACT:R-DRE-162721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Danio rerio)
REACT:R-BTA-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Bos taurus)
RHEA:68700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
RHEA:10631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + tRNA(n+1) <=> a ribonucleoside 5'-diphosphate + tRNA(n)
REACT:R-BTA-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Bos taurus)
REACT:R-HSA-8876230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	InlB:MET dimer trans-autophophorylates (Homo sapiens)
RHEA:48672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-9674529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds to TBXA2R (Rattus norvegicus)
REACT:R-SCE-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Saccharomyces cerevisiae)
REACT:R-RNO-5672304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Rattus norvegicus)
GO:0102522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity
REACT:R-CEL-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Caenorhabditis elegans)
REACT:R-BTA-140769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VII -> factor VIIa (Bos taurus)
REACT:R-GGA-8987063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Gallus gallus)
RHEA:21417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADPH
REACT:R-DRE-1604350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14:TIMP2 binds proMMP2 (Danio rerio)
RHEA:63124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl ethanolamine = ethanolamine + octadecanoate
REACT:R-MMU-5218830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates PTK2-beta (Mus musculus)
REACT:R-CFA-8866268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADBRK1,2 phosphorylate AVPR2 (Canis familiaris)
RHEA:19436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-gluconate <=> 6-phospho-D-gluconate + ADP + H(+)
RHEA:50940	skos:prefLabel	"cyclo(L-leucyl-L-phenylalanyl) synthase"
RHEA:50940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclo(L-leucyl-L-phenylalanyl) synthase"
RHEA:50940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) = cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)
REACT:R-MMU-8950724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Mus musculus)
RHEA:63963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisate(out) + ATP + H2O <=> abscisate(in) + ADP + H(+) + phosphate
REACT:R-HSA-5693346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CECRI deaminates Ade-Rib to Ino (Homo sapiens)
REACT:R-XTR-981497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Xenopus tropicalis)
REACT:R-BTA-109341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Bos taurus)
REACT:R-BTA-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Bos taurus)
REACT:R-CFA-9708533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 translocates from the cytosol to the nucleoplasm (Canis familiaris)
REACT:R-MMU-5656105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Mus musculus)
REACT:R-HSA-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Homo sapiens)
REACT:R-SSC-9023632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Sus scrofa)
REACT:R-BTA-5696490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:CLCF1 binds CNTRF (Bos taurus)
REACT:R-SSC-2161768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXA4 is converted to EXC4 by LTC4S (Sus scrofa)
REACT:R-SPO-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Schizosaccharomyces pombe)
REACT:R-HSA-9009371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)
RHEA:68428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutein + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone
RHEA:60230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2
REACT:R-GGA-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Gallus gallus)
RHEA:47136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + lithocholate = AMP + diphosphate + lithocholoyl-CoA
GO:0030165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLGF-domain binding
GO:0030165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHR-domain binding
GO:0030165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDZ domain binding
REACT:R-MMU-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Mus musculus)
REACT:R-RNO-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Rattus norvegicus)
GO:0033761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mugineic-acid 3-dioxygenase activity
GO:0033761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IDS2
GO:0033761	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
RHEA:44391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-SCE-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Saccharomyces cerevisiae)
REACT:R-SSC-9021627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
RHEA:18515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose + H2O2 => D-mannitol + O2
REACT:R-RNO-201810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ligand trap binds the ligand BMP2, blocking BMP signalling (Rattus norvegicus)
REACT:R-HSA-5340124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSN polymer binds CaPO4 (Homo sapiens)
REACT:R-GGA-372505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylcholine synaptic vesicle docking and priming (Gallus gallus)
GO:0062147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate
GO:0062147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine 4-chlorinase activity
REACT:R-MMU-5218827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 (NOX2) complex binds RAC1 (Mus musculus)
RHEA:43011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine <=> 2-aminoprop-2-enoate + H2O
RHEA:66558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dopaminyl-L-glutamyl-[protein] + NH4(+) => dopamine + L-glutaminyl-[protein]
REACT:R-RNO-1855172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Rattus norvegicus)
REACT:R-RNO-109857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 binds MAPK3 (Rattus norvegicus)
REACT:R-XTR-3149519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC decyanates CNCbl (Xenopus tropicalis)
RHEA:68164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]
RHEA:32454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate <=> all-trans-phytoene + 2 diphosphate
REACT:R-XTR-421416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proglucagon translocates from the ER Lumen to secretory granules (Xenopus tropicalis)
RHEA:37060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA + L-threonylcarbamoyladenylate => AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA
RHEA:20618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate
RHEA:30402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0033793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aureusidin synthase activity
GO:0033793	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity
REACT:R-HSA-9009936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEL cleaves cellular ssRNA (Homo sapiens)
REACT:R-DRE-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Danio rerio)
RHEA:21115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose
RHEA:50166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:61878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:35377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate => (beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O
REACT:R-MMU-9603420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 promotes SRC autophosphorylation (Mus musculus)
REACT:R-SSC-1169394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of IRF3 (Sus scrofa)
REACT:R-CEL-3149539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)
RHEA:43470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,10E,14Z)-12-hydroperoxyeicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2
RHEA:43271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GM2 + H(+) + UDP
REACT:R-HSA-435375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT2 facilitates zinc vesicular sequestration (Homo sapiens)
REACT:R-HSA-909725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IRF9 with p-STAT2:p-STAT1 (Homo sapiens)
REACT:R-HSA-5250892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botF LC cleaves target cell VAMP2 (Homo sapiens)
REACT:R-GGA-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Gallus gallus)
RHEA:71587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)
EC:2.7.8.1	skos:prefLabel	"ethanolaminephosphotransferase"
EC:2.7.8.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethanolaminephosphotransferase"
REACT:R-HSA-168312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane (Homo sapiens)
REACT:R-MMU-8951850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Mus musculus)
RHEA:50081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurodeoxycholate(in) => ADP + H(+) + phosphate + taurodeoxycholate(out)
REACT:R-XTR-5682709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI4 binds ADAM22,23,11 (Xenopus tropicalis)
RHEA:54551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose 1,5-bisphosphate + H2O <=> D-xylulose 5-phosphate + phosphate
RHEA:21888	skos:prefLabel	"12-oxophytodienoate reductase"
RHEA:21888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"12-oxophytodienoate reductase"
RHEA:21888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-OPC-8 + NADP(+) = (10Z,15Z)-12-oxophytodienoate + H(+) + NADPH
RHEA:52976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]
REACT:R-MMU-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Mus musculus)
REACT:R-MMU-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Mus musculus)
REACT:R-CEL-1655831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 translocates to the nucleus (Caenorhabditis elegans)
RHEA:43471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate
RHEA:15708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinone + H2O + phenylacetyl-CoA <=> 2 a ubiquinol + phenylglyoxylyl-CoA
REACT:R-XTR-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Xenopus tropicalis)
REACT:R-HSA-447226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-12 binds Interleukin-12 receptor (Homo sapiens)
REACT:R-CFA-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Canis familiaris)
RHEA:45127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acarbose + ATP <=> acarbose 7(IV)-phosphate + ADP + H(+)
REACT:R-HSA-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)
RHEA:54140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(49) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
RHEA:31209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA + FADH2 => FAD + H(+) + hexanoyl-CoA
RHEA:71993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-astellatene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate
RHEA:12959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + an aliphatic alcohol + H(+) => an acetyl ester + H2O
REACT:R-BTA-5693533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C (ARTEMIS) processes DNA DSB ends (Bos taurus)
RHEA:62087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glucosamine <=> AMP + D-glucosamine 6-phosphate + H(+)
REACT:R-DME-8951850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Drosophila melanogaster)
REACT:R-RNO-5686315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Rattus norvegicus)
RHEA:53227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-435244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM1 is phosphorylated (Mus musculus)
RHEA:42592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-BTA-5654679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR3 (Bos taurus)
REACT:R-CFA-2022405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)
REACT:R-DME-170861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimeric TGF-beta-1 binds to the receptor (Drosophila melanogaster)
RHEA:29142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + menaquinol-8 + nitrate <=> 2 H(+)(out) + H2O + menaquinone-8 + nitrite
GO:0018609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorobenzene dioxygenase activity
REACT:R-GGA-6798373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates DYRK2 (Gallus gallus)
GO:0008812	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline:(acceptor) oxidoreductase activity
GO:0008812	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline-cytochrome c reductase activity
GO:0008812	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	choline oxidase activity
GO:0008812	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline:acceptor 1-oxidoreductase activity
GO:0008812	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline:(acceptor) 1-oxidoreductase activity
GO:0008812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline dehydrogenase activity
REACT:R-DDI-6799545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Dictyostelium discoideum)
RHEA:15297	skos:altLabel	"galactosyltransferase I"
RHEA:15297	skos:prefLabel	"xylosylprotein 4-beta-galactosyltransferase"
RHEA:15297	skos:altLabel	"uridine diphosphogalactose-xylose galactosyltransferase"
RHEA:15297	skos:altLabel	"UDP-D-galactose:D-xylose galactosyltransferase"
RHEA:15297	skos:altLabel	"UDP-D-galactose:xylose galactosyltransferase"
RHEA:15297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP
RHEA:15297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylosylprotein 4-beta-galactosyltransferase"
REACT:R-RNO-159005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)
RHEA:27695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-2,3-dihydroxy-3-methylpentanoate => (S)-3-methyl-2-oxopentanoate + H2O
REACT:R-BTA-8850797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK13 (Bos taurus)
RHEA:58612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-octanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine
RHEA:72834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP + H2O <=> G[3'-5']pAp[3'] + H(+)
RHEA:40784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + H2O => CoA + docosanoate + H(+)
GO:0000095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine transmembrane transporter activity
GO:0000095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl methionine transporter activity
GO:0000095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Homo sapiens)
GO:0000095	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	S-adenosylmethionine transporter activity
GO:0000095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylmethionine transmembrane transporter activity
GO:0000095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAM transmembrane transporter activity
GO:0000095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylmethionine permease activity
GO:0000095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl methionine permease activity
REACT:R-HSA-9694721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)
REACT:R-RNO-390674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB1 bind ADR,NAd (Rattus norvegicus)
REACT:R-SCE-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)
RHEA:17362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-3-ureidopropanoate + H2O => H(+) + malonate + urea
RHEA:56094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n) => bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-GGA-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Gallus gallus)
REACT:R-XTR-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Xenopus tropicalis)
REACT:R-SSC-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)
GO:0047296	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)
GO:0047296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homospermidine synthase activity
REACT:R-DRE-374899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of noradrenaline  at the synapse (Danio rerio)
GO:0042054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase activity
GO:0042054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone N-methyltransferase activity
GO:0042054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methylase activity
RHEA:52266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + 2 S-adenosyl-L-methionine
RHEA:66975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose <=> alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)
RHEA:68146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (R)-3-hydroxybutanoate + NADP(+) => ethyl 3-oxobutanoate + H(+) + NADPH
REACT:R-HSA-6793666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the nucleus (Homo sapiens)
RHEA:39493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH
REACT:R-HSA-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Homo sapiens)
RHEA:15875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+) => [(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose
REACT:R-XTR-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
RHEA:32033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + gamma-curcumene => (2E,6E)-farnesyl diphosphate
REACT:R-DRE-8986995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Danio rerio)
RHEA:58548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine
RHEA:46075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + H(+) + NADH <=> hexadecanoyl-CoA + NAD(+)
RHEA:34216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) => 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH
REACT:R-DRE-8869633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NR to yield NMN (Danio rerio)
RHEA:71486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Met-enkephalin <=> L-phenylalanyl-L-methionine + L-tyrosylglycylglycine
REACT:R-GGA-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Gallus gallus)
RHEA:31232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanal + H2O + NAD(+) => 4-acetamidobutanoate + 2 H(+) + NADH
REACT:R-DRE-1861789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Danio rerio)
RHEA:51807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyhumulone + dimethylallyl diphosphate <=> diphosphate + H(+) + lupulone
REACT:R-DDI-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Dictyostelium discoideum)
RHEA:10121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine in double-stranded RNA + H(+) + H2O => inosine in double-stranded RNA + NH4(+)
REACT:R-DRE-5654582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates SHC1 (Danio rerio)
REACT:R-RNO-9687638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds IP4, IP5 and IP6  (Rattus norvegicus)
REACT:R-MMU-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Mus musculus)
RHEA:71121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhispidin + H2O + NADP(+) => H(+) + hispidin + NADPH + O2
GO:0046559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-glucuronidase activity
GO:0046559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glucosiduronase activity
GO:0046559	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucosiduronate glucuronohydrolase activity
REACT:R-BTA-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Bos taurus)
REACT:R-RNO-211966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2D6 4-hydroxylates debrisoquine (Rattus norvegicus)
RHEA:40303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dodecanedioyl-CoA = (2E)-dodecenedioyl-CoA + AH2
REACT:R-DRE-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Danio rerio)
RHEA:26043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-9-O-acetylneuraminate
REACT:R-DME-6814165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates CSA to HTAU (Drosophila melanogaster)
EC:3.4.23.40	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phytepsin"
EC:3.4.23.40	skos:prefLabel	"phytepsin"
REACT:R-HSA-190788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of junctional channels (Homo sapiens)
RHEA:66948	skos:prefLabel	"alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und 2(IV)-O-acetyltransferase"
RHEA:66948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und 2(IV)-O-acetyltransferase"
RHEA:66948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate = alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA
RHEA:22465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]
RHEA:12647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-8937989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRC1 complexes (Bos taurus)
RHEA:40168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + O2 => (2E)-hexadecenoyl-CoA + H2O2
REACT:R-DME-2993763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Drosophila melanogaster)
REACT:R-MMU-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Mus musculus)
REACT:R-MMU-198813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO dimers reduce DeHA to AscH- (Mus musculus)
RHEA:27863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-GMP + H2O => guanosine + phosphate
REACT:R-MMU-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Mus musculus)
REACT:R-SSC-2186607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
REACT:R-SSC-2161907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Sus scrofa)
GO:0061708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-5-taurinomethyluridine 2-sulfurtransferase
RHEA:71734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + tartrate(in) <=> citrate(in) + tartrate(out)
RHEA:20127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-SSC-8875071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSS3 ligates CoA to CH3COO- (Sus scrofa)
REACT:R-XTR-392752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by CK-II (Xenopus tropicalis)
REACT:R-DME-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)
RHEA:29956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + thymidine(in) => H(+)(out) + thymidine(out)
REACT:R-CFA-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Canis familiaris)
RHEA:46052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine
RHEA:71074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-cysteine(out) <=> L-arginine(out) + L-cysteine(in)
REACT:R-CFA-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Canis familiaris)
RHEA:42598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin G2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2
RHEA:70444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 => a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate
RHEA:72225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in) => 4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out)
REACT:R-GGA-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Gallus gallus)
GO:0016519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIP receptor activity
GO:0016519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-dependent insulinotropic polypeptide receptor activity
GO:0016519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gastric inhibitory peptide receptor activity
RHEA:42521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2605) in 23S rRNA => pseudouridine(2605) in 23S rRNA
REACT:R-BTA-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Bos taurus)
RHEA:48296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2
RHEA:12123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + ATP + H(+) <=> ADP-alpha-D-glucose + diphosphate
REACT:R-XTR-5358343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT palmitoylates Hh N-terminal fragment (Xenopus tropicalis)
RHEA:65768	skos:prefLabel	"N,N-dimethyl phenylurea N-demethylase"
RHEA:65768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:65768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N,N-dimethyl phenylurea N-demethylase"
RHEA:38369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA => 8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA
REACT:R-SSC-450827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Sus scrofa)
RHEA:27885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-CMP + H2O <=> 3'-CMP + H(+)
RHEA:25539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate <=> diphosphate + ent-sandaracopimara-8(14),15-diene
REACT:R-CEL-9755303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades HIFalpha (Caenorhabditis elegans)
RHEA:67583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + tauro-alpha-muricholate <=> adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate
REACT:R-XTR-8852280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds microtubule lattice in interphase cells (Xenopus tropicalis)
RHEA:54127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine h dioxetanone <=> CO2 + excited coelenteramide h monoanion + H(+)
REACT:R-SSC-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Sus scrofa)
RHEA:31091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dodecanoyl-CoA = 3-oxotetradecanoyl-CoA + CoA
REACT:R-XTR-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Xenopus tropicalis)
RHEA:15383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO => O2 + quercetin
RHEA:18257	skos:altLabel	"Coproporphyrinogen-III oxidase"
RHEA:18257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coproporphyrinogen oxidase"
RHEA:18257	skos:altLabel	"coproporphyrinogenase"
RHEA:18257	skos:prefLabel	"coproporphyrinogen oxidase"
RHEA:18257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX
RHEA:18257	skos:altLabel	"Coprogen oxidase"
RHEA:38051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-DME-4615900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB2 with SUMO3 (Drosophila melanogaster)
REACT:R-HSA-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)
REACT:R-CEL-8985943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 dimerizes (Caenorhabditis elegans)
REACT:R-MMU-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Mus musculus)
RHEA:71534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine(out) <=> guanine(in)
GO:0032132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O6-alkylguanine-DNA binding
REACT:R-GGA-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Gallus gallus)
REACT:R-RNO-548815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Rattus norvegicus)
REACT:R-HSA-2213195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of anchoring fibrils (Homo sapiens)
RHEA:30521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine => GTP + H(+) + phosphoenolpyruvate
RHEA:67832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate
REACT:R-BTA-9006873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT binding (Bos taurus)
REACT:R-DRE-379395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates 3MT to HVA (Danio rerio)
REACT:R-RNO-166387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The FA anion diffuses away laterally from UCP (Rattus norvegicus)
REACT:R-HSA-8936995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
REACT:R-BTA-159773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein S to protein S (Bos taurus)
REACT:R-MMU-9728723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Mus musculus)
RHEA:59589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + L-ornithine => ADP + beta-alanyl-L-ornithine + H(+) + phosphate
RHEA:51854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out)
RHEA:32424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + A => (R)-carvone + AH2
REACT:R-MMU-1482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by HADH (IM) (Mus musculus)
REACT:R-DRE-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Danio rerio)
RHEA:31245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH => H2O + L-4-hydroxyglutamate semialdehyde + NAD(+)
GO:0097030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	centromere-specific nucleosome binding
GO:0097030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	centromeric nucleosome binding
GO:0097030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CENP-A containing nucleosome binding
REACT:R-MMU-5607757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TRAF6 ubiquitinates TAK1 (Mus musculus)
GO:0045119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	azole:hydrogen antiporter activity
GO:0045119	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bicyclomycin/sulfathiazole:hydrogen antiporter activity
GO:0045119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	azole:proton antiporter activity
REACT:R-XTR-201629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Tau (Xenopus tropicalis)
REACT:R-BTA-5654222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PLCG1 (Bos taurus)
RHEA:55145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH
REACT:R-CFA-936960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Canis familiaris)
REACT:R-MMU-9731590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)
REACT:R-CFA-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Canis familiaris)
RHEA:19671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + phosphate => GTP + H2O
REACT:R-DRE-2022073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen triple helix formation (Danio rerio)
REACT:R-SSC-5683801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates BRCA1 (Sus scrofa)
REACT:R-CFA-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Canis familiaris)
REACT:R-XTR-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Xenopus tropicalis)
RHEA:24564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate
RHEA:24564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
RHEA:24564	skos:prefLabel	"3-oxoacid CoA-transferase"
RHEA:24564	skos:altLabel	"succinyl-CoA:3-ketoacid-CoA transferase"
RHEA:24564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxoacid CoA-transferase"
REACT:R-RNO-174251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Rattus norvegicus)
REACT:R-RNO-8855564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Rattus norvegicus)
GO:1990312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type-II cohesin domain binding
RHEA:25046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)
GO:0047671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:anthranilate adenylyltransferase activity
GO:0047671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:anthranilate N-adenylyltransferase activity
GO:0047671	skos:prefLabel	"cyclopeptine synthase"
GO:0047671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate adenylyltransferase activity
GO:0047671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine
GO:0047671	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilic acid adenylyltransferase activity
GO:0047671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclopeptine synthase"
REACT:R-SSC-5250930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH recruits histone acetyltransferases (Sus scrofa)
REACT:R-XTR-6804485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates L3MBTL2 with SUMO2 (Xenopus tropicalis)
RHEA:71153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoylpyruvate + CO2 + hnu => 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one
REACT:R-DRE-177157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Danio rerio)
REACT:R-CFA-373705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of DCC (Canis familiaris)
RHEA:55841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + UDP-alpha-D-glucuronate => calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP
REACT:R-MMU-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Mus musculus)
REACT:R-DRE-9029580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Danio rerio)
REACT:R-HSA-5653766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
GO:0070497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxy-5,6,7,8-tetrahydropterin synthase activity
REACT:R-HSA-201629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Tau (Homo sapiens)
REACT:R-SSC-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Sus scrofa)
REACT:R-HSA-2399966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates GSK3 (Homo sapiens)
REACT:R-HSA-167537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
RHEA:27351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arseno-mycothiol + H2O => arsenate + mycothiol
REACT:R-DRE-194308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Danio rerio)
REACT:R-CEL-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Caenorhabditis elegans)
REACT:R-DME-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Drosophila melanogaster)
REACT:R-RNO-73596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)
RHEA:59411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-aspartate <=> acetate + L-aspartate
RHEA:30572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine => 6 AMP + 6 diphosphate + enterobactin + 4 H(+)
GO:0004812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacyl-tRNA synthetase activity
GO:0004812	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ligase activity, forming aminoacyl-tRNA and related compounds
GO:0004812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Ligases forming aminoacyl-tRNA and related compounds"
GO:0004812	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoacyl-tRNA synthetase auxiliary protein activity
GO:0004812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacyl-tRNA ligase activity
GO:0004812	skos:prefLabel	"Ligases forming aminoacyl-tRNA and related compounds"
REACT:R-XTR-6806974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET dimers autophosphorylate (Xenopus tropicalis)
REACT:R-XTR-5218815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds NCK (Xenopus tropicalis)
REACT:R-HSA-9012315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Homo sapiens)
RHEA:57597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] <=> diphosphate + holo-[citrate lyase ACP]
REACT:R-BTA-381503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP6 binds IGF forming IGF:IGFBP6 (Bos taurus)
REACT:R-HSA-5607023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IXa associates with cell membrane (Homo sapiens)
RHEA:72463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]
REACT:R-DRE-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)
RHEA:50607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]
REACT:R-CFA-3777129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC3 containing complexes deacetylate histone (Canis familiaris)
REACT:R-MMU-174174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Mus musculus)
REACT:R-SCE-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Saccharomyces cerevisiae)
REACT:R-DRE-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Danio rerio)
REACT:R-CFA-5692408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPR2 binds NPPC (Canis familiaris)
GO:0047431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)
GO:0047431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity
GO:0047431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity
REACT:R-HSA-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Homo sapiens)
REACT:R-SSC-392263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR2 (Sus scrofa)
REACT:R-HSA-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Homo sapiens)
REACT:R-XTR-8943987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCUBE1, SCUBE3 oligomerize (Xenopus tropicalis)
RHEA:39767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:38290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalate + succinyl-CoA <=> (3S)-citramalyl-CoA + succinate
RHEA:16919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6-trihydroxypyridine + H2O + NAD(+) => 2,6-dihydroxypyridine + H(+) + NADH + O2
GO:0016899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
REACT:R-SSC-375768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Sus scrofa)
RHEA:57982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside F1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose
REACT:R-XTR-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Xenopus tropicalis)
GO:0102105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethoxycurcumin synthase activity from feruloylacetyl-CoA
GO:0016990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine iminohydrolase activity
GO:0016990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrulline iminase activity
GO:0016990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine deiminase activity
GO:0016990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine deiminase activity
GO:0016990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine dihydrolase activity
GO:0097726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lamina-associated polypeptide, emerin, MAN1 domain binding
GO:0097726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAP2, emerin, MAN1 domain binding
GO:0097726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEM domain binding
REACT:R-DRE-9708457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HM13 cleaves HMOX1 dimer (Danio rerio)
GO:0140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2B-S36 kinase activity
GO:0140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2BS36 kinase activity
GO:0140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H2B-S36 specific)
RHEA:56532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate
REACT:R-CFA-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Canis familiaris)
REACT:R-SSC-5686924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Sus scrofa)
REACT:R-RNO-8948224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)
REACT:R-MMU-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Mus musculus)
RHEA:16972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-beta-L-rhamnose
REACT:R-MTU-868608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trehalose-6-phosphate is hydrolyzed to trehalose (Mycobacterium tuberculosis)
GO:0047722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indolelactate:NAD+ oxidoreductase activity
GO:0047722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-lactate dehydrogenase activity
GO:0047722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indolelactate dehydrogenase (NADH) activity
GO:0047722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(indol-3-yl)lactate:NAD+ oxidoreductase activity
REACT:R-HSA-9674562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)
REACT:R-RNO-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Rattus norvegicus)
REACT:R-XTR-2984258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 phosphorylates NEK6/NEK7 (Xenopus tropicalis)
REACT:R-DDI-9717830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to GPP (Dictyostelium discoideum)
RHEA:41276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-eicosanoyl-sphing-4-enine => eicosanoate + sphing-4-enine
REACT:R-BTA-1605717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Bos taurus)
RHEA:37688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
RHEA:19026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate + O2 => H2O2 + NH4(+) + oxaloacetate
REACT:R-XTR-8876868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE1 cleaves EDN1(53-90) (Xenopus tropicalis)
REACT:R-BTA-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Bos taurus)
GO:0032574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template (Homo sapiens)
GO:0032574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-3' RNA helicase activity
GO:0032574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template (Homo sapiens)
GO:0032574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 5' to 3' RNA helicase activity
GO:0032574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 5'-3' RNA helicase activity
GO:0032574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' to 3' RNA helicase activity
REACT:R-RNO-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Rattus norvegicus)
REACT:R-SSC-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Sus scrofa)
RHEA:60293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine
REACT:R-SPO-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Schizosaccharomyces pombe)
REACT:R-DRE-5617143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)
REACT:R-HSA-9612278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds SPARC gene (Homo sapiens)
REACT:R-HSA-9683720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E protein gets palmitoylated (Homo sapiens)
REACT:R-SSC-9686930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is cleaved by CASP8 (Sus scrofa)
EC:2.4.2.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrimidine-nucleoside phosphorylase"
EC:2.4.2.2	skos:altLabel	"Py-NPase"
EC:2.4.2.2	skos:prefLabel	"pyrimidine-nucleoside phosphorylase"
RHEA:22987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + oxamate <=> N-carbamoyl-2-oxoglycine + phosphate
REACT:R-BTA-391157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds SKAP2 (Bos taurus)
EC:3.2.1.87	skos:prefLabel	"capsular-polysaccharide endo-1,3-alpha-galactosidase"
EC:3.2.1.87	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"capsular-polysaccharide endo-1,3-alpha-galactosidase"
EC:3.2.1.87	skos:altLabel	"polysaccharide depolymerase"
RHEA:65026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrocholate + H(+) + NADPH => 7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+)
REACT:R-RNO-1462005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-defensin alpha 5 is secreted (Rattus norvegicus)
REACT:R-DRE-392202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 12:Gi complex (Danio rerio)
RHEA:22906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Danio rerio)
REACT:R-CFA-76397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Canis familiaris)
REACT:R-RNO-5218906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 phosphorylates MLKL (Rattus norvegicus)
RHEA:72207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 hydrogencarbonate(in) = chloride(in) + 2 hydrogencarbonate(out)
REACT:R-CFA-8870489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA4,(5,6) bind PI3P (Canis familiaris)
REACT:R-SCE-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Saccharomyces cerevisiae)
REACT:R-HSA-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Homo sapiens)
REACT:R-DRE-873921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of STAT1 to p-IFNGR1 (Danio rerio)
RHEA:44457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine
REACT:R-DME-77592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Intronless Pre-mRNA at 3'-end (Drosophila melanogaster)
REACT:R-MMU-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Mus musculus)
REACT:R-RNO-964759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alternative endo-mannosidase I route (Rattus norvegicus)
REACT:R-XTR-388808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-2 monomer (Xenopus tropicalis)
REACT:R-BTA-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Bos taurus)
RHEA:65037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-PFA-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Plasmodium falciparum)
REACT:R-HSA-373713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC heterodimerizes with UNC-5:Netrin-1 (Homo sapiens)
REACT:R-DRE-8877902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated AR binds RUNX2 (Danio rerio)
RHEA:67008	skos:altLabel	"messenger ribonucleate guanine 7-methyltransferase"
RHEA:67008	skos:altLabel	"guanine-7-methyltransferase"
RHEA:67008	skos:prefLabel	"mRNA (guanine-N(7))-methyltransferase"
RHEA:67008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mRNA (guanine-N(7))-methyltransferase"
RHEA:67008	skos:altLabel	"messenger RNA guanine 7-methyltransferase"
RHEA:67008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine
REACT:R-GGA-433711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cis-homodimerization of nectins (Gallus gallus)
REACT:R-XTR-5661123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate Me2K5-histone H3 (Xenopus tropicalis)
REACT:R-DDI-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Dictyostelium discoideum)
REACT:R-CEL-183072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR non-clathrin mediated endocytosis (Caenorhabditis elegans)
REACT:R-MMU-2559439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD14:LPS binds CR3 (Mus musculus)
REACT:R-BTA-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Bos taurus)
RHEA:48184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:69983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-9638125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G1P to G6P (Danio rerio)
RHEA:32457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone => (-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-9035133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the CETP gene (Homo sapiens)
REACT:R-MMU-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Mus musculus)
RHEA:48007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O
RHEA:23666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + AH2 => A + a (2R)-2-hydroxycarboxylate
REACT:R-DME-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Drosophila melanogaster)
RHEA:27408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H2O + pyruvate <=> a ubiquinol + acetate + CO2
REACT:R-DDI-5658435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs bind RAS:GTP (Dictyostelium discoideum)
REACT:R-RNO-5692770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Rattus norvegicus)
RHEA:34422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-lariciresinol + NADP(+) <=> (+)-pinoresinol + H(+) + NADPH
RHEA:22682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + NH4(+) => dCTP + H(+) + H2O
REACT:R-CEL-5689085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds polyUb-PARK2 (Caenorhabditis elegans)
REACT:R-HSA-5617445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXD1 chromatin is activated (Homo sapiens)
REACT:R-GGA-398193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC beta-mediated PIP2 hydrolysis (Gallus gallus)
RHEA:36934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:23226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-beta-D-glucosyl-trans-zeatin + UDP => trans-zeatin + UDP-alpha-D-glucose
RHEA:65017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorothalonil + H2O => 4-hydroxychlorothalonil + chloride + 2 H(+)
REACT:R-HSA-2187401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)
REACT:R-SPO-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Schizosaccharomyces pombe)
REACT:R-HSA-381309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
RHEA:34799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-didehydroadipoyl-CoA + acetyl-CoA = 3-oxo-5,6-didehydrosuberyl-CoA + CoA
RHEA:34799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxo-5,6-didehydrosuberyl-CoA thiolase"
RHEA:34799	skos:prefLabel	"3-oxo-5,6-didehydrosuberyl-CoA thiolase"
REACT:R-HSA-194689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Homo sapiens)
GO:0090595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA:L-lysine N6-acetyltransferase
RHEA:20810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + N-acetyl-7-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate
REACT:R-DME-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Drosophila melanogaster)
RHEA:32750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine(in) <=> ethanolamine(out)
RHEA:62174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylethanolamine + phosphate => an N-acylethanolamine phosphate + H2O
RHEA:71621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + 2 thiosulfate(in) => (S)-malate(in) + 2 thiosulfate(out)
GO:1990424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine kinase activity
GO:1990424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein arginine kinase activity
GO:0102635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-deoxycorticosterone reductase activity
REACT:R-GGA-9700121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN,MDK):PTPRZ oligomerizes (Gallus gallus)
REACT:R-DME-434381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Drosophila melanogaster)
REACT:R-RNO-6804468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO2 (Rattus norvegicus)
REACT:R-SPO-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)
REACT:R-DDI-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Dictyostelium discoideum)
REACT:R-HSA-69140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap (Homo sapiens)
REACT:R-DME-190245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1b binds to FGF (Drosophila melanogaster)
REACT:R-XTR-879914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3 stimulation induces Vav binding to Tec kinase (Xenopus tropicalis)
RHEA:53814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin] => cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-SSC-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Sus scrofa)
RHEA:41128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine
RHEA:31444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-sedoheptulose 7-phosphate => ADP + D-sedoheptulose 1,7-bisphosphate + H(+)
GO:0022880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine PTS transporter activity
GO:0022880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity
REACT:R-RNO-9020255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Rattus norvegicus)
RHEA:47247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)
GO:0001786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylserine binding
REACT:R-DRE-4551679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO2 (Danio rerio)
RHEA:42149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine
RHEA:64403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-amino acid tripeptide(out) + H(+)(out) <=> an L-amino acid tripeptide(in) + H(+)(in)
REACT:R-HSA-9021954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds OPRK1 gene promoter (Homo sapiens)
REACT:R-DDI-1169404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ISG15 from E1 to E2 (UBCH8) (Dictyostelium discoideum)
RHEA:59079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)
RHEA:51514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + oxalate => H2O + oxamate
REACT:R-CEL-111966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 binds CALM1:4Ca2+ (Caenorhabditis elegans)
RHEA:57812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-2-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite
RHEA:68359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-aspartyl-L-glutamate <=> L-glutamate + N-acetyl-L-aspartate
REACT:R-CFA-72647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cap-bound mRNA is activated by helicases  (Canis familiaris)
REACT:R-XTR-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Xenopus tropicalis)
RHEA:45851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydodecanoyl-CoA + NADP(+) <=> 3-oxododecanoyl-CoA + H(+) + NADPH
REACT:R-DRE-195251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the destruction complex (Danio rerio)
REACT:R-CFA-6809263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)
REACT:R-MMU-1250346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Mus musculus)
REACT:R-HSA-975122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Homo sapiens)
RHEA:62762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-HSA-1006143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C3b (Homo sapiens)
REACT:R-HSA-5667111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 K63-Ubiquitinates SNCAIP (Homo sapiens)
GO:0004478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine synthetase activity
GO:0004478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosylmethionine synthetase activity
GO:0004478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine-activating enzyme
GO:0004478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:L-methionine S-adenosyltransferase activity
GO:0004478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine adenosyltransferase activity
GO:0004478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine synthetase activity
GO:0004478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine S-adenosyltransferase activity
GO:0004478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine synthase activity
GO:0004478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-methionine adenosyltransferase activity
GO:0004478	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AdoMet synthetase activity
REACT:R-DRE-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Danio rerio)
REACT:R-XTR-5672969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF (Xenopus tropicalis)
RHEA:21155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-proline <=> cis-4-hydroxy-D-proline
REACT:R-DRE-5617179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates TNNI3 (Danio rerio)
RHEA:54102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
REACT:R-MMU-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Mus musculus)
RHEA:67581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + tauro-alpha-muricholate => adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate
RHEA:16670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + xanthine => H(+) + NADH + urate
REACT:R-HSA-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Homo sapiens)
REACT:R-RNO-140736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Rattus norvegicus)
REACT:R-DRE-9609742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Danio rerio)
REACT:R-DRE-8869603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A13 transports NCA from extracellular region to cytosol (Danio rerio)
EC:5.1.3.21	skos:prefLabel	"maltose epimerase"
EC:5.1.3.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maltose epimerase"
REACT:R-BTA-3149539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)
REACT:R-RNO-170126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin B1 in the CRS domain (Rattus norvegicus)
RHEA:15619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+) + Fe(III)-[cytochrome c] => Fe(3+) + Fe(II)-[cytochrome c]
REACT:R-DRE-532603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin mediated activation of N-WASP (Danio rerio)
RHEA:37644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:66143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + octopamine <=> CoA + H(+) + N-acetyloctopamine
REACT:R-SCE-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Saccharomyces cerevisiae)
REACT:R-XTR-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Xenopus tropicalis)
RHEA:50587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) <=> 15-oxoprostaglandin E1 + H(+) + NADPH
REACT:R-MMU-77321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Mus musculus)
REACT:R-HSA-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Homo sapiens)
REACT:R-RNO-9015379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (compounds) binds IIa (Rattus norvegicus)
REACT:R-RNO-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Rattus norvegicus)
RHEA:64660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate
GO:0050647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding
GO:0050647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
REACT:R-XTR-9025999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Xenopus tropicalis)
REACT:R-DDI-9020278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Dictyostelium discoideum)
REACT:R-DRE-1236965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Export of peptide loaded MHC class I complex to PM (Danio rerio)
REACT:R-MMU-8951676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TEADs and YAP1 (Mus musculus)
RHEA:40029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-vitexifolin A + diphosphate => 9alpha-copalyl diphosphate + H2O
REACT:R-GGA-9727607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ binds sacubitrilat (Gallus gallus)
RHEA:10229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate => cis-aconitate + H2O
RHEA:10122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine in double-stranded RNA + NH4(+) => adenosine in double-stranded RNA + H(+) + H2O
REACT:R-SSC-9686521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2:CCNA phosphorylates TERF2 (Sus scrofa)
RHEA:23853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + O2 => cis,cis-muconate + 2 H(+)
GO:0140537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription regulator activator activity
REACT:R-HSA-5653886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1 binds LALBA (Homo sapiens)
RHEA:48392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
REACT:R-SSC-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Sus scrofa)
EC:2.4.2.5	skos:prefLabel	"nucleoside ribosyltransferase"
EC:2.4.2.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside ribosyltransferase"
RHEA:52856	skos:prefLabel	"dimethylglycine dehydrogenase"
RHEA:52856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine
RHEA:52856	skos:altLabel	"Me2GlyDH"
RHEA:52856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylglycine dehydrogenase"
RHEA:52380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)
GO:0008177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate dehydrogenase (ubiquinone) activity
GO:0008177	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate:ubiquinone oxidoreductase activity
GO:0008177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinol:fumarate oxidoreductase activity
GO:0008177	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	respiratory complex II
GO:0008177	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	menaquinol: fumarate oxidoreductase activity
GO:0008177	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)
GO:0008177	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)
GO:0008177	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinic dehydrogenase activity
REACT:R-SSC-2514790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by MMP14 (Sus scrofa)
REACT:R-DME-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Drosophila melanogaster)
RHEA:17111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+) => FMNH2 + N-methylnicotinate + O2
REACT:R-XTR-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
REACT:R-DRE-1358790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates ERBB3 (Danio rerio)
REACT:R-DRE-374758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Somatostatin receptors bind somatostatin and cortistatin (Danio rerio)
RHEA:58984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + H2O + O2 = acrylate + H(+) + H2O2
REACT:R-MMU-400509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Mus musculus)
GO:0004694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eukaryotic translation initiation factor 2alpha kinase activity
RHEA:65916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + pyruvate = H2O + kynurenate + L-alanine
GO:0034191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein A-I receptor binding
REACT:R-XTR-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Xenopus tropicalis)
RHEA:50978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D2(in) => prostaglandin D2(out)
REACT:R-PFA-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Plasmodium falciparum)
RHEA:66974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose
RHEA:32538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> 4-hydroxy-2-oxohexanoate
REACT:R-RNO-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Rattus norvegicus)
EC:3.4.17.-	skos:prefLabel	"Metallocarboxypeptidases"
EC:3.4.17.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Metallocarboxypeptidases"
RHEA:20041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H2O + NADP(+) = 2 H(+) + malonate + NADPH
REACT:R-RNO-9624800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LBR (Rattus norvegicus)
REACT:R-BTA-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Bos taurus)
REACT:R-HSA-8877338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and NFATC2 bind the IL2 gene promoter (Homo sapiens)
REACT:R-MMU-9753285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)
REACT:R-HSA-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Homo sapiens)
REACT:R-XTR-5666070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Xenopus tropicalis)
REACT:R-MMU-3321805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSL acetylates histone H4 (Mus musculus)
REACT:R-BTA-176700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Bos taurus)
REACT:R-CFA-427910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
REACT:R-SSC-5654989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Sus scrofa)
RHEA:38076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA
REACT:R-HSA-1912391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 is phosphorylated by CDK8 (Homo sapiens)
RHEA:38510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate
REACT:R-XTR-2022398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Xenopus tropicalis)
REACT:R-RNO-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Rattus norvegicus)
RHEA:35372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate
REACT:R-GGA-2132277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor H binds to surface-bound C3b (Gallus gallus)
REACT:R-DRE-6814418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes formation of G-beta:G-gamma heterodimers (Danio rerio)
RHEA:33221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-8864125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)
GO:0097657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3',5'-nucleoside bisphosphate phosphatase"
GO:0097657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 3',5'-bisphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate
GO:0097657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-nucleotide bisphosphate phosphatase activity
GO:0097657	skos:prefLabel	"3',5'-nucleoside bisphosphate phosphatase"
RHEA:49063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain alkane + FMNH2 + O2 <=> a long chain fatty alcohol + FMN + H(+) + H2O
REACT:R-PFA-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Plasmodium falciparum)
REACT:R-HSA-159757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
RHEA:58249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O => ADP-D-ribose + H(+) + L-glutamyl-[protein]
RHEA:68799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + H2O <=> alpha-D-glucose + D-glucose
RHEA:18952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol
REACT:R-SSC-209891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine is oxidised to noradrenaline (Sus scrofa)
REACT:R-MMU-5691411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Mus musculus)
RHEA:20894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl phosphate + CoA => butanoyl-CoA + phosphate
RHEA:47930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactate + 2 H(+) + NADPH => (2S)-3-sulfolactaldehyde + H2O + NADP(+)
REACT:R-SPO-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Schizosaccharomyces pombe)
REACT:R-BTA-8875661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA3 associates with activated MET receptor (Bos taurus)
GO:0009884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokinin receptor activity
REACT:R-RNO-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Rattus norvegicus)
RHEA:25009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]
GO:0106418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity
GO:0106418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	murein peptide ligase
GO:0034012	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD AMP-lyase (cyclic-FMN-forming) activity
GO:0034012	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity
GO:0034012	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FMN cyclase activity
GO:0034012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD-AMP lyase (cyclizing) activity
REACT:R-DRE-6807224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-BGLAP to BGLAP (Danio rerio)
RHEA:46990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-N-methylmyosmine + H2O2 => (R)-6-hydroxynicotine + O2
REACT:R-HSA-2730876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IKK-beta by TAK1 (Homo sapiens)
REACT:R-MMU-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Mus musculus)
REACT:R-DRE-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
REACT:R-XTR-351987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A6-mediated uptake of taurine and beta-alanine (Xenopus tropicalis)
REACT:R-SSC-388855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin-releasing hormone receptor binds PRH (Sus scrofa)
REACT:R-MMU-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Mus musculus)
RHEA:17677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase"
RHEA:17677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)
RHEA:17677	skos:prefLabel	"2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase"
GO:0000227	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxaloacetate carrier activity
GO:0000227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate secondary active transmembrane transporter activity
REACT:R-HSA-5263628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAV3:TRIM72:DYSF binds ANXAs (Homo sapiens)
REACT:R-HSA-143468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)
REACT:R-GGA-205112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Gallus gallus)
REACT:R-CFA-9027275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)
REACT:R-SSC-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Sus scrofa)
RHEA:35776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + UDP-3-oxo-alpha-D-glucose => 2-oxoglutaramate + UDP-alpha-D-kanosamine
REACT:R-XTR-2022056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPG and CSPG translocate to the lysosome for degradation (Xenopus tropicalis)
REACT:R-HSA-9033284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2 promotes TIAM1 phosphorylation (Homo sapiens)
REACT:R-DRE-419334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melatonin receptors can bind melatonin (Danio rerio)
RHEA:46599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + rifampicin <=> 2'-N-hydroxyrifampicin + H2O + NADP(+)
EC:3.4.11.20	skos:prefLabel	"aminopeptidase Ey"
EC:3.4.11.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminopeptidase Ey"
GO:0047411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-(N-acetylaminomethylene)succinic acid hydrolase activity
GO:0047411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acetamidomethylene)succinate hydrolase activity
GO:0047411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)
GO:0097643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amylin receptor activity
REACT:R-RNO-5654651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS3 (Rattus norvegicus)
REACT:R-DRE-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Danio rerio)
EC:3.6.5.3	skos:altLabel	"peptide-release factor (RF)"
EC:3.6.5.3	skos:altLabel	"peptide-release or termination factor"
EC:3.6.5.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-synthesizing GTPase"
EC:3.6.5.3	skos:altLabel	"initiation factor (IF)"
EC:3.6.5.3	skos:altLabel	"elongation factor (EF)"
EC:3.6.5.3	skos:prefLabel	"protein-synthesizing GTPase"
REACT:R-RNO-9699579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of FLT3  (Rattus norvegicus)
RHEA:23341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-oct-2-ulosonate => D-arabinose + pyruvate
GO:0018518	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase
GO:0018518	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity
GO:0018518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity
REACT:R-HSA-175993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNMT transfers CH3 group from AdoMet to Hist (Homo sapiens)
RHEA:13781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-amino-acid oxidase"
RHEA:13781	skos:altLabel	"ophio-amino-acid oxidase"
RHEA:13781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)
RHEA:13781	skos:prefLabel	"L-amino-acid oxidase"
REACT:R-BTA-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
RHEA:21912	skos:prefLabel	"pyruvate oxidase (CoA-acetylating)"
RHEA:21912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + O2 + pyruvate = acetyl-CoA + CO2 + H2O2
RHEA:21912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate oxidase (CoA-acetylating)"
RHEA:62558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcatechol + CO2 => 3,4-dihydroxyphenylacetate + H(+)
RHEA:17055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate
RHEA:69846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in RNA + NAD(+) <=> a uridine in RNA + H(+) + NADH
REACT:R-CFA-6809707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTMR2 (Canis familiaris)
RHEA:51570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:12904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arginine + H2O <=> D-ornithine + urea
GO:0033154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type oligogalacturonide transporter activity
GO:0033154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligogalacturonide-transporting ATPase activity
GO:0033154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligogalacturonide transporting ATPase activity
GO:0033154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent oligogalacturonide transmembrane transporter activity
GO:0033154	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oligogalacturonide transmembrane transporter activity
GO:0033154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled oligogalacturonide transmembrane transporter activity
REACT:R-MMU-4084912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arresten binds integrin alpha1beta1 (Mus musculus)
GO:0052845	skos:prefLabel	"diphosphoinositol-polyphosphate diphosphatase"
GO:0052845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO:0052845	skos:altLabel	"diphosphoinositol-polyphosphate phosphohydrolase"
GO:0052845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diphosphoinositol-polyphosphate diphosphatase"
GO:0052845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate
GO:0052845	skos:altLabel	"DIPP"
REACT:R-SSC-8867754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
REACT:R-SSC-199154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD200 binds to CD200R (Sus scrofa)
RHEA:25649	skos:prefLabel	"(-)-isopiperitenone reductase"
RHEA:25649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,5R)-isopulegone + NADP(+) = (6R)-isopiperitenone + H(+) + NADPH
RHEA:25649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-isopiperitenone reductase"
REACT:R-BTA-4332235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds TGFBR2 (Bos taurus)
REACT:R-RNO-159729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)
REACT:R-DDI-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Dictyostelium discoideum)
RHEA:60071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)
RHEA:61870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:33240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine + NAD(+) => aminoacetone + CO2 + NADH
REACT:R-RNO-443439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-Src binds Raf1 (Rattus norvegicus)
GO:0052616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-ol oxidase activity
EC:3.4.24.45	skos:altLabel	"Crotalus atrox metalloendopeptidase f"
EC:3.4.24.45	skos:altLabel	"hemorrhagic toxin f"
EC:3.4.24.45	skos:prefLabel	"atrolysin F"
EC:3.4.24.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"atrolysin F"
REACT:R-MMU-164834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enzyme-bound ATP is released (Mus musculus)
REACT:R-SSC-9015379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (compounds) binds IIa (Sus scrofa)
RHEA:54646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + H(+) + H2O => trans-4-hydroxy-L-proline
RHEA:27277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH
RHEA:59469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted glutathione + H2O => an S-substituted L-cysteinylglycine + L-glutamate
RHEA:70912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)
REACT:R-CFA-216756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)
REACT:R-HSA-5685985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Homo sapiens)
RHEA:64989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H2O => (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
REACT:R-DRE-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Danio rerio)
REACT:R-DRE-5218841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
REACT:R-HSA-5654651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS3 (Homo sapiens)
REACT:R-HSA-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Homo sapiens)
REACT:R-GGA-9669893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type I TKIs (Gallus gallus)
REACT:R-RNO-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Rattus norvegicus)
GO:0047324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate-glycerone phosphotransferase activity
GO:0047324	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:glycerone phosphotransferase activity
REACT:R-HSA-8939667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA5 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)
REACT:R-BTA-5358579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase delta polymerizes DNA across single stranded gap (Bos taurus)
REACT:R-PFA-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Plasmodium falciparum)
REACT:R-XTR-8875816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds activated MET receptor (Xenopus tropicalis)
RHEA:13811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspulvinone H + 2 diphosphate => aspulvinone E + 2 dimethylallyl diphosphate
REACT:R-GGA-751039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (12/13) reassociates with G beta:gamma (Gallus gallus)
RHEA:59615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-L-ornithine + H2O <=> beta-alanine + L-ornithine
REACT:R-DME-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Drosophila melanogaster)
REACT:R-SSC-8987070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Sus scrofa)
RHEA:36203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)
RHEA:33209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate => ATP + H(+) + L-glutamate + NADPH
RHEA:47137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + lithocholate => AMP + diphosphate + lithocholoyl-CoA
RHEA:32325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
RHEA:69896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(out) + Na(+)(out) => cytidine(in) + Na(+)(in)
REACT:R-BTA-4332358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CaM and CAMK2 autophosphorylation (Bos taurus)
REACT:R-DME-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Drosophila melanogaster)
REACT:R-RNO-5687653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Rattus norvegicus)
RHEA:64307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenylpropylamine + pyruvate <=> 1-phenylpropan-1-one + L-alanine
REACT:R-HSA-9024624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6 (Homo sapiens)
REACT:R-MMU-173725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C9 binds C5b:C6:C7:C8 (Mus musculus)
RHEA:10874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + L-aspartate => H2O + N-acyl-L-aspartate
RHEA:66769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + coproporphyrin I(in) + H2O => ADP + coproporphyrin I(out) + H(+) + phosphate
REACT:R-CFA-5654562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Canis familiaris)
GO:1990162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K4 deacetylase activity
GO:1990162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K4 deacetylase activity
GO:1990162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone deacetylase activity (H3-K4 specific)
REACT:R-CFA-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Canis familiaris)
REACT:R-HSA-6785178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Homo sapiens)
REACT:R-DME-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Drosophila melanogaster)
RHEA:57140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
RHEA:46766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:19344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + octane + 2 reduced [rubredoxin] <=> H2O + octan-1-ol + 2 oxidized [rubredoxin]
REACT:R-SSC-5607742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)
REACT:R-SSC-2730856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Sus scrofa)
RHEA:22816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xylose = alpha-D-xylulofuranose
RHEA:22816	skos:prefLabel	"xylose isomerase"
RHEA:22816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xylose isomerase"
RHEA:22816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose = alpha-D-fructose
RHEA:22816	skos:altLabel	"D-xylose ketoisomerase"
REACT:R-HSA-9670114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H3.3 deposition at telomere (Homo sapiens)
REACT:R-BTA-977317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Bos taurus)
REACT:R-HSA-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Homo sapiens)
REACT:R-DME-6809777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR2:SBF1 (Drosophila melanogaster)
REACT:R-SSC-9624017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SHC1 binds integrin alpha5beta1:fibronectin (Sus scrofa)
RHEA:71133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-asparagine(in) + Na(+)(in) => H(+)(in) + L-asparagine(out) + Na(+)(out)
RHEA:56504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-199425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)
REACT:R-MMU-708349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD2 oligomerizes (Mus musculus)
RHEA:50998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine => L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine
REACT:R-MMU-193064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3-like proteins reducde ANDST to TEST (Mus musculus)
RHEA:31424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate
REACT:R-SSC-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Sus scrofa)
REACT:R-DDI-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Dictyostelium discoideum)
RHEA:15865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + tryptamine = 4-hydroxytryptamine + A + H2O
RHEA:15865	skos:prefLabel	"tryptamine 4-monooxygenase"
RHEA:15865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptamine 4-monooxygenase"
RHEA:57951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytoluene + H(+) + NADH + O2 <=> 3-methylcatechol + H2O + NAD(+)
REACT:R-SSC-202216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 (Sus scrofa)
REACT:R-CFA-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Canis familiaris)
REACT:R-XTR-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Xenopus tropicalis)
RHEA:15646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] => 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate
RHEA:39569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-HSA-5671993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIT-3 binds DLG4 (Homo sapiens)
REACT:R-SSC-5695980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD10 dehydrogenates S-2MPDA-CoA (Sus scrofa)
REACT:R-CFA-420598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:Nectin-4 trans heterodimer formation (Canis familiaris)
REACT:R-GGA-8852317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GTSE1 (Gallus gallus)
REACT:R-HSA-2453863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRA6 transports atROL from extracellular region to cytosol (Homo sapiens)
REACT:R-GGA-5607721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NIK (Gallus gallus)
RHEA:55463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:33723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)
REACT:R-SSC-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Sus scrofa)
REACT:R-MMU-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Mus musculus)
REACT:R-XTR-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Xenopus tropicalis)
REACT:R-CEL-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)
REACT:R-DDI-3204311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)
REACT:R-SSC-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Sus scrofa)
REACT:R-XTR-1433395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of sSCF (Xenopus tropicalis)
RHEA:69361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + H(+) + H2O2 + L-tyrosyl-[protein] => 3-bromo-L-tyrosyl-[protein] + 2 H2O
RHEA:36344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 => 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)
REACT:R-DRE-6814675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Danio rerio)
RHEA:60909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in tRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:41588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)
REACT:R-DME-1247922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCT transforms gGluCys to OPRO (Drosophila melanogaster)
REACT:R-HSA-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-RNO-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Rattus norvegicus)
REACT:R-SSC-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Sus scrofa)
RHEA:39759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylquercetin 3'-O-methyltransferase activity
REACT:R-SSC-3965447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein subunits dissociate from WNT:FZD complex (Sus scrofa)
RHEA:64663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate
REACT:R-MMU-196402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Mus musculus)
RHEA:61136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + quercetin + succinate
REACT:R-HSA-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)
REACT:R-CEL-8875816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds activated MET receptor (Caenorhabditis elegans)
RHEA:57468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + UDP-alpha-D-glucose = 1-O-[(E)-feruloyl]-beta-D-glucose + UDP
RHEA:14081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + indole
RHEA:14081	skos:altLabel	"tryptophan synthase alpha"
RHEA:14081	skos:altLabel	"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase"
RHEA:14081	skos:altLabel	"indole-3-glycerol phosphate lyase"
RHEA:14081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-glycerol-phosphate lyase"
RHEA:14081	skos:altLabel	"indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase"
RHEA:14081	skos:altLabel	"indole glycerol phosphate hydrolase"
RHEA:14081	skos:altLabel	"TSA"
RHEA:14081	skos:altLabel	"indoleglycerolphosphate aldolase"
RHEA:14081	skos:altLabel	"indole synthase"
RHEA:14081	skos:prefLabel	"indole-3-glycerol-phosphate lyase"
REACT:R-HSA-445069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1-EGFR trans-heterodimerization (Homo sapiens)
RHEA:55536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)
REACT:R-BTA-9029517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Bos taurus)
REACT:R-SPO-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Schizosaccharomyces pombe)
REACT:R-DRE-110355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MUTYH glycosylase by APEX1 at the AP site (Danio rerio)
RHEA:44555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine
RHEA:15220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone + hexadecanoyl-CoA <=> CoA + ecdysone hexadecanoate
REACT:R-GGA-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Gallus gallus)
REACT:R-RNO-5250217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP binds ARL2BP (Rattus norvegicus)
RHEA:63601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neocasomorphin => L-isoleucine + neocasomorphin-(1-5)
REACT:R-DRE-9008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylation (Danio rerio)
REACT:R-DRE-5138432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 is phosphorylated by PKC (Danio rerio)
RHEA:18194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate
REACT:R-CFA-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Canis familiaris)
REACT:R-DDI-8938829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Dictyostelium discoideum)
RHEA:40965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-aminophenoxazin-3-one + 6 H2O => 4 2-aminophenol + 3 O2
REACT:R-SSC-5607737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 oligomerizes (Sus scrofa)
REACT:R-MMU-190065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TrkA receptor internalizes to endosomes (Mus musculus)
RHEA:13112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetamidofluorene + H2O + NAD(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADH
REACT:R-DME-8950522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1:p-STAT4 translocates to the nucleus (Drosophila melanogaster)
REACT:R-XTR-391211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trace amine-associated receptors can bind trace amines (Xenopus tropicalis)
REACT:R-DME-8850534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes G-protein beta 5 folding (Drosophila melanogaster)
REACT:R-RNO-375384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bombesin-like receptors bind bombesin homologues (Rattus norvegicus)
REACT:R-RNO-389919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds pBTLA (Rattus norvegicus)
REACT:R-RNO-430347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MigFilin associates with Filamin and F-actin (Rattus norvegicus)
REACT:R-BTA-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Bos taurus)
RHEA:63361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2
REACT:R-GGA-450257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)
RHEA:56153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-BTA-5683967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)
REACT:R-XTR-2029271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
REACT:R-MMU-349593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with Fibronectin (Mus musculus)
REACT:R-GGA-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Gallus gallus)
RHEA:66551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 4-nitrophenol <=> 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate
REACT:R-BTA-5687673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN recruits LIG3:XRCC1 to MMEJ sites (Bos taurus)
RHEA:15375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + palmatine + S-adenosyl-L-homocysteine => columbamine + S-adenosyl-L-methionine
RHEA:63722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	losartan-2-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate
RHEA:48978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + NAD(+) + pyocyanin => 5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2
REACT:R-GGA-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Gallus gallus)
RHEA:66967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
RHEA:29229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + indole(out) => H(+)(in) + indole(in)
REACT:R-CEL-199425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLPP dephosphorylates S473 in AKT (Caenorhabditis elegans)
RHEA:52815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)
REACT:R-MMU-4551616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RPA1 (RPA70) with SUMO2,3 (Mus musculus)
REACT:R-HSA-9687465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSV1 RIR1 binds RIPK1 (Homo sapiens)
RHEA:30637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
RHEA:10734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + CO2 + diphosphate + firefly oxyluciferin + hnu => ATP + firefly D-luciferin + O2
RHEA:68796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + H2O = alpha-D-glucose + D-glucose
RHEA:25513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine
REACT:R-HSA-1564117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIV degradation by MMP9,13 (Homo sapiens)
REACT:R-BTA-5654407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates SHC1 (Bos taurus)
RHEA:21043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-9667619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B,2 bind atosiban (Bos taurus)
REACT:R-CFA-9718360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide agonists (Canis familiaris)
REACT:R-HSA-5423672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2, 3A4 oxidise AFB1 to AFNBO (Homo sapiens)
REACT:R-MMU-211929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C19 5-hydroxylates omeprazole (Mus musculus)
REACT:R-RNO-3640844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 binds RibC-AXIN:TNKS complex (Rattus norvegicus)
RHEA:12360	skos:prefLabel	"13-hydroxylupanine O-tigloyltransferase"
RHEA:12360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"13-hydroxylupanine O-tigloyltransferase"
RHEA:12360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine = 13-(2-methylcrotonoyloxy)lupanine + CoA
REACT:R-RNO-8964634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Rattus norvegicus)
RHEA:72498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + prostaglandin E2(out) <=> glutarate(out) + prostaglandin E2(in)
REACT:R-DME-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Drosophila melanogaster)
REACT:R-DRE-200396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Creatine transport across the plasma membrane (Danio rerio)
REACT:R-BTA-201422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Bos taurus)
REACT:R-HSA-4090281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Homo sapiens)
REACT:R-CEL-174273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:Cdk2 complexes to the nucleus (Caenorhabditis elegans)
REACT:R-SCE-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Saccharomyces cerevisiae)
RHEA:17877	skos:prefLabel	"catechol O-methyltransferase"
RHEA:17877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"catechol O-methyltransferase"
RHEA:17877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S-adenosyl-L-homocysteine
REACT:R-PFA-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Plasmodium falciparum)
REACT:R-HSA-1614460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of procollagen type VI (Homo sapiens)
REACT:R-HSA-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Homo sapiens)
RHEA:24197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)
REACT:R-HSA-8848355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes retinyl palmitate (Homo sapiens)
REACT:R-CFA-8856223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Canis familiaris)
RHEA:35735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH
RHEA:34700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-alpha-isocomene + diphosphate
REACT:R-DME-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Drosophila melanogaster)
RHEA:55024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + H2O + NADP(+) <=> (E)-ferulate + 2 H(+) + NADPH
REACT:R-HSA-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Homo sapiens)
REACT:R-DME-8933446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Drosophila melanogaster)
REACT:R-DRE-140736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Danio rerio)
RHEA:55582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate => ATP + H2O + L-glutamine
RHEA:44017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) => 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH
RHEA:22672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate
RHEA:22672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"presqualene diphosphate synthase"
RHEA:22672	skos:prefLabel	"presqualene diphosphate synthase"
REACT:R-BTA-429730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Bos taurus)
RHEA:61885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate
REACT:R-BTA-158766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Bos taurus)
REACT:R-BTA-5654628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS3 (Bos taurus)
REACT:R-CFA-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Canis familiaris)
REACT:R-BTA-5671702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP1G2 binds HGS and CHMP2A (Bos taurus)
REACT:R-DRE-173723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C8 binds C5b:C6:C7 (Danio rerio)
REACT:R-MMU-5684250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Mus musculus)
REACT:R-CFA-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Canis familiaris)
RHEA:49393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
RHEA:46029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + tetradecanoate => (2R)-hydroxytetradecanoate + H2O
RHEA:57648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + trichosetin = equisetin + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-1008220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of globin genes under control of the beta globin control region (Homo sapiens)
GO:0050477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	epsilon-lysine acylase activity
GO:0050477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-lysine deacylase activity
GO:0050477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-acyl-L-lysine amidohydrolase activity
GO:0050477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-N-acyl-L-lysine amidohydrolase activity
REACT:R-HSA-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Homo sapiens)
REACT:R-HSA-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Homo sapiens)
RHEA:66534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]
GO:0031692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1B adrenergic receptor binding
GO:0031692	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-1B adrenergic receptor ligand
GO:0047328	skos:prefLabel	"acyl-phosphate--hexose phosphotransferase"
GO:0047328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-phosphate--hexose phosphotransferase"
GO:0047328	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-phosphate:D-hexose phosphotransferase activity
GO:0047328	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexose phosphate:hexose phosphotransferase activity
GO:0047328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-phosphate-hexose phosphotransferase activity
GO:0047328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl phosphate + D-hexose = a carboxylate + D-hexose phosphate + H(+)
GO:0005201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular matrix structural constituent
GO:0005201	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	extracellular matrix glycoprotein
GO:0005201	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core matrisome
GO:0005201	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	core extracellular matrix
RHEA:54595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate
REACT:R-DRE-8940074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NMN (Danio rerio)
REACT:R-DRE-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Danio rerio)
REACT:R-HSA-1358792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates activated ERBB3 (Homo sapiens)
REACT:R-SSC-5218891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomer binds MLKL (Sus scrofa)
REACT:R-HSA-5685606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC2D binds KLRB1 (Homo sapiens)
REACT:R-HSA-380949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK is dephosphorylated (Homo sapiens)
REACT:R-DRE-2430535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL phosphorylates ENSA (Danio rerio)
RHEA:16173	skos:altLabel	"(S)-norlaudanosoline synthase"
RHEA:16173	skos:prefLabel	"(S)-norcoclaurine synthase"
RHEA:16173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-norcoclaurine synthase"
RHEA:16173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O
RHEA:60835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine in mRNA + H2O <=> a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate
GO:0102381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stevioside glucosyltransferase activity (rebaudioside A forming)
REACT:R-HSA-977392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CEBPD (Homo sapiens)
REACT:R-HSA-8937369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAD2 binds ESR1 (Homo sapiens)
REACT:R-GGA-5660665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 binds MALT (Gallus gallus)
RHEA:39903	skos:prefLabel	"beta-(isoxazolin-5-on-4-yl)-L-alanine synthase"
RHEA:39903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)
RHEA:39903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-(isoxazolin-5-on-4-yl)-L-alanine synthase"
REACT:R-HSA-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)
EC:3.1.1.73	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"feruloyl esterase"
EC:3.1.1.73	skos:altLabel	"hydroxycinnamoyl esterase"
EC:3.1.1.73	skos:altLabel	"ferulic acid esterase"
EC:3.1.1.73	skos:altLabel	"cinnamoyl ester hydrolase"
EC:3.1.1.73	skos:prefLabel	"feruloyl esterase"
REACT:R-CEL-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Caenorhabditis elegans)
REACT:R-CFA-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Canis familiaris)
REACT:R-DME-203625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOSTRIN mediated translocation of eNOS from plasma membrane (Drosophila melanogaster)
REACT:R-SSC-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Sus scrofa)
REACT:R-HSA-1295604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-RAF dissociates from S111/S120 p-SPRY2 (Homo sapiens)
RHEA:67145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + jasmonate + O2 => (1R,2R)-12-hydroxyjasmonate + CO2 + succinate
REACT:R-DME-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Drosophila melanogaster)
REACT:R-SSC-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Sus scrofa)
REACT:R-HSA-3223200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
RHEA:38438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-SPO-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Schizosaccharomyces pombe)
REACT:R-HSA-9011083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO1 gene expression is inhibited by LHX2 (Homo sapiens)
REACT:R-GGA-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Gallus gallus)
RHEA:16262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + succinyl-CoA => CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]
REACT:R-SSC-912685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBP43 binds IFNAR2 and prevents JAK1 interaction (Sus scrofa)
REACT:R-RNO-8956025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Rattus norvegicus)
REACT:R-RNO-5692408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPR2 binds NPPC (Rattus norvegicus)
RHEA:22546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O
RHEA:49395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor V -> factor Va + factor V activation peptide (Sus scrofa)
REACT:R-BTA-159761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Bos taurus)
REACT:R-HSA-6788867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3K phosphorylates ketosamines (Homo sapiens)
REACT:R-GGA-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Gallus gallus)
RHEA:69680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-beta-D-glucoside + H2O => apigenin + beta-D-glucose
RHEA:65700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:44242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol
REACT:R-DRE-446077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP230 interacts with keretin K5/K14 (Danio rerio)
REACT:R-RNO-192065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)
RHEA:45833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH
REACT:R-MMU-8853793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET complexes bind GRB2 (Mus musculus)
REACT:R-GGA-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Gallus gallus)
RHEA:24373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] => H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine
REACT:R-DDI-9018894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Dictyostelium discoideum)
RHEA:11536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choline oxidase"
RHEA:11536	skos:prefLabel	"choline oxidase"
RHEA:11536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + H2O + 2 O2 = glycine betaine + H(+) + 2 H2O2
RHEA:71451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bradykinin + H2O = bradykinin(1-7) + L-Phe-L-Arg
REACT:R-RNO-71825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Rattus norvegicus)
REACT:R-BTA-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Bos taurus)
RHEA:15889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamine = L-glutamate + NH4(+)
RHEA:11506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + sterigmatocystin => 6-demethylsterigmatocystin + S-adenosyl-L-methionine
RHEA:66998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpentanoyl-CoA + AMP + diphosphate => 2-methylpentanoate + ATP + CoA
RHEA:48767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) <=> 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH
RHEA:10778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+)
GO:0034237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase A regulatory subunit binding
GO:0034237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA regulatory subunit binding
GO:0034237	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein kinase A anchoring activity
RHEA:53481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)
REACT:R-MMU-8871370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Mus musculus)
RHEA:11340	skos:altLabel	"2-oxo-5-guanidinopentanoate carboxy-lyase"
RHEA:11340	skos:altLabel	"2-oxo-5-guanidinopentanoate decarboxylase"
RHEA:11340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-guanidino-2-oxopentanoate decarboxylase"
RHEA:11340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO2
RHEA:11340	skos:altLabel	"2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase"
RHEA:11340	skos:prefLabel	"5-guanidino-2-oxopentanoate decarboxylase"
REACT:R-MMU-193703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta is activated (Mus musculus)
REACT:R-XTR-5659781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 forms a heterodimer with BARD1 (Xenopus tropicalis)
REACT:R-SPO-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Schizosaccharomyces pombe)
REACT:R-CFA-427555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)
RHEA:30431	skos:prefLabel	"taraxerol synthase"
RHEA:30431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taraxerol synthase"
RHEA:30431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = taraxerol
RHEA:67005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate
REACT:R-DRE-9756138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)
REACT:R-CEL-191422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate-5-phosphate is further phosphorylated. (Caenorhabditis elegans)
REACT:R-CFA-8869568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM1 binds TFAP2A homodimer (Canis familiaris)
REACT:R-HSA-4551721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)
GO:0015474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	autotransporter activity
RHEA:24029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-(trimethylamino)butanoate + O2 => carnitine + CO2 + succinate
REACT:R-BTA-420724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds Ca2+ (Bos taurus)
RHEA:69641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + phloretin => H2O + phlorizin
REACT:R-CFA-2065539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:Importin beta-1 dissociates (Canis familiaris)
REACT:R-SPO-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Schizosaccharomyces pombe)
REACT:R-DRE-1606564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Danio rerio)
RHEA:71602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + maleate(in) <=> 2-oxoglutarate(in) + maleate(out)
RHEA:16991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O
REACT:R-GGA-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Gallus gallus)
REACT:R-BTA-5693584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Bos taurus)
REACT:R-RNO-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Rattus norvegicus)
REACT:R-CFA-5693551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)
REACT:R-SCE-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Saccharomyces cerevisiae)
REACT:R-CFA-5669240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLNA binds PAK1 (Canis familiaris)
REACT:R-XTR-1306969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)
REACT:R-HSA-1253343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds ERBB4s80 (Homo sapiens)
REACT:R-HSA-419428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR2-5 bind S1P (Homo sapiens)
REACT:R-GGA-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Gallus gallus)
REACT:R-SSC-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Sus scrofa)
REACT:R-DRE-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Danio rerio)
REACT:R-MMU-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Mus musculus)
REACT:R-GGA-8852809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPN, CPB2 cleave C3a, C5a (Gallus gallus)
RHEA:41410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine
RHEA:51785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlorisovalerophenone + dimethylallyl diphosphate => deoxyhumulone + diphosphate
REACT:R-RNO-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Rattus norvegicus)
REACT:R-BTA-9018499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and EP300 are recruited to TFF3 promoter (Bos taurus)
RHEA:61610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbB protein]-disulfide + a quinol => [DsbB protein]-dithiol + a quinone
RHEA:34142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(9)-tetrahydrocannabinolate + H(+) <=> CO2 + Delta(9)-tetrahydrocannabinol
GO:0102636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine gamma-glutamylcyclotransferase activity
GO:0030348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syntaxin-3 binding
REACT:R-SCE-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Saccharomyces cerevisiae)
REACT:R-BTA-3000074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN2 binds RCbl in the circulation (Bos taurus)
REACT:R-CEL-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)
REACT:R-CEL-2167942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII ectodomain shedding (Caenorhabditis elegans)
REACT:R-HSA-9686088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDMD (Homo sapiens)
REACT:R-GGA-433950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 recruits TAK1 kinase complex  (Gallus gallus)
RHEA:53321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)
REACT:R-DME-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-DRE-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Danio rerio)
REACT:R-CFA-1299297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of THIK (Canis familiaris)
REACT:R-RNO-5689972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)
REACT:R-DRE-5654571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS3 (Danio rerio)
REACT:R-DME-5693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYM reduces P2C to PPCA (Drosophila melanogaster)
RHEA:33804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidinal + NAD(+) => 2 H(+) + L-histidine + NADH
RHEA:47596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP
RHEA:47596	skos:prefLabel	"dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase"
RHEA:47596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase"
REACT:R-HSA-1031713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAF binds the GAS promoter elements in the IFNG-regulated genes (Homo sapiens)
REACT:R-RNO-5340124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSN polymer binds CaPO4 (Rattus norvegicus)
RHEA:53577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0018462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity
GO:0018462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxymethyl)benzenesulphonate dehydrogenase activity
GO:0018462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxymethyl)benzenesulfonate dehydrogenase activity
GO:0018462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulfobenzyl alcohol dehydrogenase activity
RHEA:55482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-170072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Xenopus tropicalis)
REACT:R-XTR-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Xenopus tropicalis)
RHEA:45100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-demethylmitomycin B + S-adenosyl-L-methionine = mitomycin B + S-adenosyl-L-homocysteine
REACT:R-SSC-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Sus scrofa)
RHEA:16537	skos:altLabel	"dihydroxy fatty acid phosphatase"
RHEA:16537	skos:altLabel	"soluble epoxide hydrolase"
RHEA:16537	skos:prefLabel	"lipid-phosphate phosphatase"
RHEA:16537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipid-phosphate phosphatase"
RHEA:16537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate
RHEA:16537	skos:altLabel	"hydroxy fatty acid phosphatase"
RHEA:16537	skos:altLabel	"hydroxy lipid phosphatase"
REACT:R-CFA-8941628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
REACT:R-DME-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Drosophila melanogaster)
REACT:R-RNO-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Rattus norvegicus)
REACT:R-DME-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Drosophila melanogaster)
GO:0047516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propane-1,3-diol:NAD+ 1-oxidoreductase activity
GO:0047516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-propanediol dehydrogenase activity
GO:0047516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-propanediol:NAD+ oxidoreductase activity
GO:0047516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-PD:NAD+ oxidoreductase activity
GO:0047516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-propanediol oxidoreductase activity
GO:0047516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxypropionaldehyde reductase activity
REACT:R-MMU-5626988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds NSMAF (Mus musculus)
REACT:R-SSC-210271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and MDL-1 (Sus scrofa)
RHEA:65392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH = (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)
RHEA:40245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanoyl-CoA + NAD(+)
REACT:R-XTR-2168888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha1-Microglobulin binds heme (Xenopus tropicalis)
REACT:R-BTA-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Bos taurus)
RHEA:67666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid => [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O
REACT:R-GGA-5655193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIAA0101 double monoubiquitination (Gallus gallus)
REACT:R-RNO-6782628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates STAM2:HGS (Rattus norvegicus)
REACT:R-HSA-9036012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch) (Homo sapiens)
RHEA:20435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose + H(+) + NADH => NAD(+) + xylitol
RHEA:40377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP
REACT:R-HSA-4411373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK translocates to nucleus (Homo sapiens)
REACT:R-HSA-1799326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)
REACT:R-DME-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Drosophila melanogaster)
RHEA:16588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-165028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)
RHEA:31637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc => beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O
REACT:R-DDI-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Dictyostelium discoideum)
REACT:R-SPO-5423117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates MeK21-histone H4 (Schizosaccharomyces pombe)
RHEA:13364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + sn-glycerol 3-phosphate <=> CDP-glycerol + diphosphate
RHEA:11188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-cyano-L-alanine + 2 H2O = L-aspartate + NH4(+)
RHEA:11188	skos:prefLabel	"cyanoalanine nitrilase"
RHEA:11188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanoalanine nitrilase"
REACT:R-DME-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Drosophila melanogaster)
REACT:R-MMU-8953946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Mus musculus)
REACT:R-DRE-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Danio rerio)
RHEA:68287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + L-seryl-[protein] <=> CoA + O-hexanoyl-L-seryl-[protein]
RHEA:44111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + heptanal + NAD(+) <=> 2 H(+) + heptanoate + NADH
REACT:R-DDI-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Dictyostelium discoideum)
REACT:R-HSA-3656261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)
RHEA:43812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine
GO:0043918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine aminopropyl transferase activity
GO:0043918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine aminopropyltransferase activity
RHEA:60962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP => 18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose
RHEA:31077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H2O => (3S)-3-hydroxydodecanoyl-CoA
REACT:R-GGA-9684627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds CYSLTR1 antagonists (Gallus gallus)
REACT:R-SCE-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Saccharomyces cerevisiae)
REACT:R-CEL-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Caenorhabditis elegans)
REACT:R-DDI-5663050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHI and DHICA polymerise forming eumelanin (Dictyostelium discoideum)
RHEA:30715	skos:prefLabel	"geraniol isomerase"
RHEA:30715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geraniol isomerase"
RHEA:30715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol = (S)-linalool
RHEA:50911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 <=> A + a 3-demethylubiquinol + H2O
REACT:R-SSC-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Sus scrofa)
RHEA:43541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[isocitrate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]
RHEA:54035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)
REACT:R-SSC-430311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rsu-1 interacts with Pinch1 (Sus scrofa)
RHEA:62209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Rattus norvegicus)
RHEA:64638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyl benzoate + CoA => benzoyl-CoA + butan-1-ol
GO:0005451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monovalent cation:proton antiporter activity
GO:0005451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monovalent cation:hydrogen antiporter activity
REACT:R-BTA-9632033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GalNAc to chondroitin (Bos taurus)
REACT:R-HSA-191422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate-5-phosphate is further phosphorylated. (Homo sapiens)
REACT:R-CFA-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Canis familiaris)
REACT:R-DRE-9691215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFR2 dimer (Danio rerio)
REACT:R-MMU-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Mus musculus)
REACT:R-GGA-68916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Gallus gallus)
REACT:R-SSC-391936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP1 receptor can bind PGE2 (Sus scrofa)
RHEA:20339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + H(+) + sulfate => (R)-2-O-sulfolactate + H2O
GO:0047940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronokinase activity
GO:0047940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronokinase (phosphorylating)
GO:0047940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucurono-glucuronokinase activity
GO:0047940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-glucuronate 1-phosphotransferase activity
REACT:R-DME-5654565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Drosophila melanogaster)
REACT:R-GGA-421161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine + H2O + NAD+ => xanthine + NADH + H+ (Gallus gallus)
REACT:R-BTA-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Bos taurus)
REACT:R-DME-390141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D inhibits WTS (Drosophila melanogaster)
REACT:R-MMU-5665751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP:FMNL2 binds Profilin:G-actin (Mus musculus)
RHEA:31653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O
RHEA:53879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in tRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate
GO:0008240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tripeptidyl-peptidase activity
REACT:R-GGA-9649963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC3 channel blockers bind ASIC3 trimer (Gallus gallus)
RHEA:50141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O
RHEA:27729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate
REACT:R-BTA-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Bos taurus)
RHEA:64113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-phenylalanine + H2O => a fatty acid + L-phenylalanine
REACT:R-HSA-4791278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC truncation mutants have impaired AXIN binding (Homo sapiens)
RHEA:70963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-phenylalanine + H2O + O2 = 3-phenylpyruvate + H2O2 + NH4(+)
REACT:R-CFA-9690494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB translocates to the endosome membrane (Canis familiaris)
RHEA:12236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinate dehydrogenase"
RHEA:12236	skos:altLabel	"nicotinic acid hydroxylase"
RHEA:12236	skos:altLabel	"nicotinate hydroxylase"
RHEA:12236	skos:prefLabel	"nicotinate dehydrogenase"
RHEA:12236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH
RHEA:38931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine
REACT:R-DRE-8964340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq-BTK complex dissociates to Active BTK and Gq (Danio rerio)
RHEA:61560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:15920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldopyranose + NAD(+) <=> aldono-1,5-lactone + H(+) + NADH
REACT:R-DDI-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:32917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycero-3-phospho-1D-myo-inositol(in) => sn-glycero-3-phospho-1D-myo-inositol(out)
REACT:R-DRE-2485182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Danio rerio)
RHEA:44383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-demethylubiquinol + S-adenosyl-L-methionine <=> a ubiquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:69934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine(out) + Na(+)(out) <=> inosine(in) + Na(+)(in)
REACT:R-GGA-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Gallus gallus)
RHEA:63392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + Fe(II)-heme o + H2O = AH2 + Fe(II)-heme i
REACT:R-XTR-166271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Xenopus tropicalis)
RHEA:36698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid <=> desmethyldescarbamoylnovobiocin + dTDP + H(+)
RHEA:60056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)
REACT:R-HSA-8957241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP73 tetramer translocates to the nucleus (Homo sapiens)
REACT:R-DME-4608854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 are recruited to the DVL2:PARD6A complex (Drosophila melanogaster)
REACT:R-XTR-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Xenopus tropicalis)
REACT:R-DDI-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Dictyostelium discoideum)
REACT:R-BTA-9020610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Bos taurus)
RHEA:18216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + CTP + H(+) <=> CDP-D-glucose + diphosphate
REACT:R-DME-5623643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH13 reduces atRAL to atROL (Drosophila melanogaster)
RHEA:55292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (pseudouridine(54)-N(1))-methyltransferase"
RHEA:55292	skos:altLabel	"m(1)Psi methyltransferase"
RHEA:55292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine
RHEA:55292	skos:prefLabel	"tRNA (pseudouridine(54)-N(1))-methyltransferase"
REACT:R-BTA-5433067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Bos taurus)
REACT:R-RNO-389995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Rattus norvegicus)
REACT:R-DME-214845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
RHEA:13450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH
RHEA:26152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate
RHEA:26152	skos:prefLabel	"6,7-dimethyl-8-ribityllumazine synthase"
RHEA:26152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6,7-dimethyl-8-ribityllumazine synthase"
RHEA:26152	skos:altLabel	"lumazine synthase"
REACT:R-BTA-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Bos taurus)
REACT:R-CFA-176494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to 27HCHOL (Canis familiaris)
REACT:R-DRE-5668735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX3 complex (Danio rerio)
REACT:R-SSC-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Sus scrofa)
REACT:R-HSA-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Homo sapiens)
RHEA:24246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + tropinone => NADP(+) + pseudotropine
REACT:R-CFA-2730900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to pUb-TRAF6 (Canis familiaris)
REACT:R-SCE-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Saccharomyces cerevisiae)
RHEA:65145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + berkeleyone A + O2 => CO2 + H2O + preaustinoid A + succinate
REACT:R-HSA-6802922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
RHEA:31608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhodopin => all-trans-lycopene + H2O
REACT:R-DME-5218916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPK2/3 phosphorylates HSP27 (Drosophila melanogaster)
REACT:R-XTR-5579023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA2(869-1464) binds KAT6A(1-1118) (Xenopus tropicalis)
REACT:R-DME-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Drosophila melanogaster)
RHEA:66721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) => ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate
GO:0052831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Homo sapiens)
GO:0052831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
REACT:R-BTA-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Bos taurus)
GO:0004152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroorotate dehydrogenase activity
RHEA:22755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + uracil <=> AH2 + barbiturate + H(+)
REACT:R-MMU-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Mus musculus)
REACT:R-XTR-8937613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHBP binds CRH (Xenopus tropicalis)
REACT:R-DRE-873924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IFNGR1 by JAK kinases (Danio rerio)
REACT:R-HSA-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Homo sapiens)
REACT:R-CFA-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Canis familiaris)
RHEA:23734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CO2 + isopentenyl diphosphate + phosphate => (R)-5-diphosphomevalonate + ATP
RHEA:34777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxosteroid + CO2 + NADH => a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+)
REACT:R-HSA-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Homo sapiens)
RHEA:11303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-5-O-methyl-myo-inositol + NAD(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH
RHEA:25772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparagine + O2 = (2S,3S)-3-hydroxyasparagine + CO2 + succinate
RHEA:25772	skos:altLabel	"L-asparagine 3-hydroxylase"
RHEA:25772	skos:prefLabel	"L-asparagine oxygenase"
RHEA:25772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-asparagine oxygenase"
REACT:R-BTA-9714481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the ER membrane (Bos taurus)
REACT:R-RNO-427528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Rattus norvegicus)
GO:0000215	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	yeast 2'-phosphotransferase activity
GO:0000215	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2'-phosphotransferase activity
GO:0000215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA 2'-phosphotransferase activity
GO:0000215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity
GO:0000215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Tpt1
GO:0000215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Tpt1p
GO:0000215	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-phospho-tRNA:NAD+ phosphotransferase activity
REACT:R-CEL-5696119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)
REACT:R-BTA-177927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to EGF:EGFR:GRB2:GAB1 (Bos taurus)
REACT:R-DME-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Drosophila melanogaster)
RHEA:37051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:62456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-glutamate = diphosphate + L-glutamyl-5'-AMP
REACT:R-HSA-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Homo sapiens)
RHEA:30478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oroxylin A 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + oroxylin A
RHEA:48633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O
REACT:R-CFA-170084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdc2 complexes (Canis familiaris)
REACT:R-GGA-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Gallus gallus)
RHEA:54796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) = an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH
RHEA:54796	skos:prefLabel	"2-alkyl-3-oxoalkanoate reductase"
RHEA:54796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-alkyl-3-oxoalkanoate reductase"
RHEA:56328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O = 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)
GO:0031687	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	A2A adenosine receptor ligand
GO:0031687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A2A adenosine receptor binding
REACT:R-CEL-71541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Caenorhabditis elegans)
RHEA:10262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + Mg(2+)(in) + phosphate => ATP + H2O + Mg(2+)(out)
GO:0050094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine-glyoxylate aminotransferase activity
GO:0050094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-methionine:glyoxylate aminotransferase activity
GO:0050094	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MGAT activity
GO:0050094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine-glyoxylate transaminase activity
REACT:R-HSA-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Homo sapiens)
RHEA:53342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NAD(+)
REACT:R-BTA-3322014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-a (Bos taurus)
REACT:R-RNO-9759169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Rattus norvegicus)
RHEA:40380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
RHEA:33394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C20 sphinganine 1-phosphate + H2O <=> C20 sphinganine + phosphate
REACT:R-DRE-378975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follitropin is a heterodimer (Danio rerio)
RHEA:40997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA
REACT:R-DRE-174959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT1 (Danio rerio)
REACT:R-SSC-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Sus scrofa)
RHEA:17957	skos:altLabel	"malonate-semialdehyde dehydratase"
RHEA:17957	skos:prefLabel	"acetylenecarboxylate hydratase"
RHEA:17957	skos:altLabel	"acetylenemonocarboxylate hydratase"
RHEA:17957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate = H2O + propynoate
RHEA:17957	skos:altLabel	"alkynoate hydratase"
RHEA:17957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylenecarboxylate hydratase"
RHEA:49897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate
RHEA:13411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH => 7-aminomethyl-7-carbaguanine + 2 NADP(+)
REACT:R-DDI-9025996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Dictyostelium discoideum)
REACT:R-BTA-180073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Bos taurus)
RHEA:35888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:45871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA
RHEA:43733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O => 1,3-diacyl-sn-glycerol + a fatty acid + H(+)
REACT:R-XTR-6784959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPHL hydrolyses VACV to ACV (Xenopus tropicalis)
RHEA:45019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine <=> L-selenomethionine + tetrahydropteroyltri-L-glutamate
REACT:R-MMU-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Mus musculus)
REACT:R-DRE-9610156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)
REACT:R-HSA-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Homo sapiens)
REACT:R-DME-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Drosophila melanogaster)
RHEA:51073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenol + an aryl sulfate => a phenol + an aryl sulfate
RHEA:66488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quillate + UDP-alpha-D-glucose = quillaic acid 28-beta-D-glucoside + UDP
GO:0140691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA folding chaperone
REACT:R-DRE-1067640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R-2 (Danio rerio)
RHEA:68938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + NADP(+) + nonanal => ATP + H(+) + NADPH + nonanoate
RHEA:37649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-SSC-9707505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to CLEC1B dimer (Sus scrofa)
REACT:R-HSA-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Homo sapiens)
REACT:R-CFA-9026777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)
REACT:R-CFA-9796368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 binds STUB1 (Canis familiaris)
RHEA:61274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + H2O2 + NH4(+) => H2O + L-2-aminopentanoate + O2
RHEA:26408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) <=> H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate
RHEA:33294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:69216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) = (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH
REACT:R-HSA-6800253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the BCL6 gene (Homo sapiens)
RHEA:26048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Rattus norvegicus)
RHEA:13233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine
REACT:R-DRE-507719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62:MEKK3 binds to TRAF6 (Danio rerio)
REACT:R-XTR-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Xenopus tropicalis)
REACT:R-HSA-163810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) (Homo sapiens)
GO:0004427	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inorganic pyrophosphatase activity
GO:0004427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic diphosphate phosphatase activity
GO:0004427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inorganic diphosphatase activity
GO:0004427	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphate phosphohydrolase activity
GO:0004427	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphate phosphohydrolase activity
REACT:R-MMU-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Mus musculus)
REACT:R-BTA-873926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNGR (Bos taurus)
REACT:R-MMU-8933446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Mus musculus)
RHEA:45040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + hydroxylamine = 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl
REACT:R-MMU-9769235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGED1 binds NPAS4 (Mus musculus)
REACT:R-BTA-8854466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds RELN (Bos taurus)
REACT:R-GGA-420980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Gallus gallus)
RHEA:71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(in) + L-serine(out) => L-phenylalanine(out) + L-serine(in)
REACT:R-HSA-9707516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM dissociates from MetHb (Homo sapiens)
REACT:R-CEL-2993780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of SUMO1 from E1 to UBE2I (UBC9) (Caenorhabditis elegans)
GO:0102543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epsilon-rhodomycinone methylesterase activity
RHEA:46634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH
RHEA:19668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-CoA + NAD(+) <=> 6-carboxyhex-2-enoyl-CoA + H(+) + NADH
RHEA:19178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine => (3S)-3,6-diaminohexanoate
GO:0005118	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sevenless ligand
GO:0005118	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sev ligand
GO:0005118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sevenless binding
GO:0005118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sev binding
RHEA:16199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + H(+) + NADPH => (3S)-3-hydroxybutanoyl-CoA + NADP(+)
RHEA:57562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Xenopus tropicalis)
REACT:R-MMU-432688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Mus musculus)
REACT:R-BTA-70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate + H2O => 4-imidazolone-5-propionate (Bos taurus)
REACT:R-RNO-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Rattus norvegicus)
REACT:R-XTR-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)
RHEA:72608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-AMP + CoA => (E)-sinapoyl-CoA + AMP + H(+)
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxybutyryl acyl carrier protein dehydrase activity
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonoyl-[acyl-carrier protein] hydratase activity
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybutyryl acyl carrier protein dehydratase activity
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonoyl-[acyl-carrier-protein] hydratase activity
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	crotonyl acyl carrier protein hydratase activity
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	crotonoyl-acyl-carrier-protein hydratase activity
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl acyl carrier protein hydrase activity
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase activity
GO:0047450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonoyl-ACP hydratase activity
REACT:R-BTA-210974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS-1 to Tie2 bound  Grb2 (Bos taurus)
REACT:R-CFA-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Canis familiaris)
RHEA:39939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
RHEA:47684	skos:prefLabel	"1,2-beta-oligoglucan phosphorylase"
RHEA:47684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n) + phosphate = [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
RHEA:47684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,2-beta-oligoglucan phosphorylase"
REACT:R-DDI-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Dictyostelium discoideum)
RHEA:36986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA
REACT:R-BTA-8870346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Bos taurus)
EC:3.4.24.60	skos:prefLabel	"dactylysin"
EC:3.4.24.60	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dactylysin"
EC:3.4.24.60	skos:altLabel	"peptide hormone inactivating endopeptidase"
RHEA:57805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-3-nitrobenzene + NADH + O2 => 4-chlorocatechol + NAD(+) + nitrite
GO:0102907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sesquisabinene synthase activity
GO:0016728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor
GO:0016728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
RHEA:31031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl cis-(+)-abscisate + UDP
REACT:R-DRE-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Danio rerio)
REACT:R-SCE-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Saccharomyces cerevisiae)
RHEA:47655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 1-phosphate + H2O <=> phosphate + ribitol
REACT:R-CFA-3791149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Canis familiaris)
RHEA:46577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + sitosterol => 2 H2O + NADP(+) + stigmasterol
REACT:R-DME-3240957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PRC2-EZH2 complex (Drosophila melanogaster)
RHEA:20306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + H2O + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH
REACT:R-BTA-196950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTRAP hydrolyzes FMN to RIB (Bos taurus)
RHEA:15668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucose + L-lysyl-[protein] <=> H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]
RHEA:44071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)
RHEA:50589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-PGF2alpha + NADP(+) => 15-oxoprostaglandin F2alpha + H(+) + NADPH
RHEA:14317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	morphine + NAD(+) = H(+) + morphinone + NADH
REACT:R-SSC-9624789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPB translocates from ER membrane to multivesicle body (Sus scrofa)
REACT:R-PFA-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Plasmodium falciparum)
RHEA:32706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> 8-hydroxycopalyl diphosphate
RHEA:33046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-camphor + H(+) + NADPH + O2 <=> (+)-6-exo-hydroxycamphor + H2O + NADP(+)
REACT:R-CFA-109449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Canis familiaris)
RHEA:22179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Xenopus tropicalis)
REACT:R-BTA-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Bos taurus)
RHEA:35049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O + Mo-molybdopterin => adenylyl-molybdopterin + H(+) + molybdate
REACT:R-HSA-9010951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO1 binds NRP1 (Homo sapiens)
REACT:R-CFA-2022379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Canis familiaris)
REACT:R-MMU-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Mus musculus)
RHEA:69197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-glutamyl-[beta-tubulin] => ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate
REACT:R-SPO-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Schizosaccharomyces pombe)
RHEA:10410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopristanoyl-CoA + CoA => 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA
REACT:R-MMU-9027321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Mus musculus)
REACT:R-BTA-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Bos taurus)
RHEA:30378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-thujopsene + diphosphate
REACT:R-DRE-5685156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2 (Danio rerio)
RHEA:68689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) => 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
RHEA:37006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA
RHEA:24880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dehydro-L-sorbose + AH2 => A + L-sorbopyranose
REACT:R-GGA-2473596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP15 (Gallus gallus)
REACT:R-MMU-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Mus musculus)
REACT:R-GGA-994000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)
REACT:R-DDI-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Dictyostelium discoideum)
RHEA:15843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-phosphate + NADP(+)
REACT:R-RNO-6810357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fillagrin and keratin intermediate filaments polymerise forming a network (Rattus norvegicus)
REACT:R-RNO-74740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SHC1 to insulin receptor (Rattus norvegicus)
RHEA:61413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(D-erythrulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine
REACT:R-MMU-9013108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOC (Mus musculus)
REACT:R-HSA-5357780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
RHEA:14699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesal + H(+) + NADPH => (2E,6E)-farnesol + NADP(+)
RHEA:29961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose
RHEA:59261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine
RHEA:60608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine
REACT:R-MMU-9706390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds interacting proteins at trans-Golgi network (Mus musculus)
REACT:R-CEL-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Caenorhabditis elegans)
REACT:R-RNO-6786239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)
RHEA:55663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-beta-carotene + 2 O2 <=> 2 A + echinenone + 3 H2O
REACT:R-HSA-9604328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates NOTCH4 (Homo sapiens)
REACT:R-SSC-4088130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds FOXM1 (Sus scrofa)
GO:0005353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose transmembrane transporter activity
GO:0005353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose permease activity
GO:0005353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Homo sapiens)
GO:0005353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose porter activity
REACT:R-HSA-1483203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is dephosphorylated to DAG by LPIN (Homo sapiens)
RHEA:64670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2
RHEA:67948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP
RHEA:65248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 5 H(+) + 5 malonyl-CoA = 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O
RHEA:63138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione => adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione
REACT:R-DDI-2328033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds latent TGF-beta (Dictyostelium discoideum)
RHEA:13280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate <=> [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate
REACT:R-MMU-9021627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
REACT:R-DRE-205262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Direct recruitment of PI3K to p-KIT (Danio rerio)
RHEA:61461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in RNA + S-adenosyl-L-methionine => a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine
RHEA:48143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite
RHEA:69250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+) => H2O + sinigrin
REACT:R-RNO-418904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A1 and A3 receptors bind adenosine (Rattus norvegicus)
RHEA:69767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-enal + H2O + NAD(+) = (E)-non-2-enoate + 2 H(+) + NADH
RHEA:62747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mevastatin <=> (S)-2-methylbutanoate + compactin diol lactone + H(+)
EC:3.4.21.107	skos:altLabel	"HrtA heat shock protein"
EC:3.4.21.107	skos:altLabel	"high temperature requirement protease A"
EC:3.4.21.107	skos:prefLabel	"peptidase Do"
EC:3.4.21.107	skos:altLabel	"protease Do"
EC:3.4.21.107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidase Do"
RHEA:47033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA => 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]
RHEA:43714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + dodecanoyl-AMP => ATP + dodecanoate + H(+)
RHEA:71878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurocholate(out) <=> 2 Na(+)(in) + taurocholate(in)
REACT:R-DME-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Drosophila melanogaster)
REACT:R-HSA-5603087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MAT1A does not transfer Ado from ATP to L-Met (Homo sapiens)
GO:0044012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H2A-K9 specific)
GO:0044012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H2A-K9 specific)
GO:0044012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H2A-K9 specific)
GO:0044012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A-K9 acetyltransferase activity
GO:0044012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AK9 acetyltransferase activity
REACT:R-CFA-2730858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of BTK/ITK (Canis familiaris)
RHEA:33930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 <=> 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde
RHEA:12018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-HSA-1791172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of WIPI1 (Homo sapiens)
RHEA:71251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylopyranose = L-xylulose
RHEA:29981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine(out) + H(+)(out) => 2'-deoxyadenosine(in) + H(+)(in)
REACT:R-DME-352385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Drosophila melanogaster)
RHEA:44119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosan-1-ol + hexadecanoyl-CoA <=> CoA + eicosanyl hexadecanoate
REACT:R-MMU-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Mus musculus)
RHEA:26019	skos:altLabel	"mannosylfructose-6-phosphate phosphatase"
RHEA:26019	skos:altLabel	"MFPP"
RHEA:26019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosylfructose-phosphate phosphatase"
RHEA:26019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O = beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate
RHEA:26019	skos:prefLabel	"mannosylfructose-phosphate phosphatase"
REACT:R-MMU-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Mus musculus)
REACT:R-BTA-3215385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Bos taurus)
REACT:R-DRE-3215448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Danio rerio)
REACT:R-CFA-2046298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to a branch of keratan (Canis familiaris)
RHEA:37939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate
REACT:R-DRE-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Danio rerio)
REACT:R-DRE-6799409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates TP53 (Danio rerio)
RHEA:15510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:36484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA
REACT:R-HSA-5602063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP26B1 does not 4-hydroxylate atRA (Homo sapiens)
REACT:R-GGA-264622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is acetylated to AcCho by CHAT (Gallus gallus)
REACT:R-MMU-159761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Mus musculus)
RHEA:21585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propane-1,2-diol 1-phosphate => H(+) + hydroxyacetone phosphate + NADH
RHEA:51159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)
REACT:R-GGA-9009554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer:SDC1 binds CSF1R (Gallus gallus)
REACT:R-HSA-8983876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds IL12RB2:IL12RB2 (Homo sapiens)
RHEA:38107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-threo-3-deoxy-hexylosonate aldolase"
RHEA:38107	skos:prefLabel	"L-threo-3-deoxy-hexylosonate aldolase"
RHEA:38107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-galactonate = L-glyceraldehyde + pyruvate
RHEA:25421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O => 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate
GO:0043810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine N(alpha)-acyltransferase
GO:0043810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine-acyl[acyl carrier protein] N-acyltransferase activity
GO:0043810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine-acyl [acyl carrier protein] N-acyltransferase activity
RHEA:50617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + nonan-2-one => (3E)-nonen-2-one + H(+) + NADPH
REACT:R-CFA-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Canis familiaris)
GO:0052600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diaminopropane oxidase activity
GO:0052600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propane-1,3-diamine oxidase activity
GO:0052600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylenediamine oxidase activity
RHEA:26086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)
REACT:R-HSA-879925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)
RHEA:32280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + 2 H(+) + 2 H2O => (S)-ureidoglycolate + CO2 + 2 NH4(+)
REACT:R-BTA-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Bos taurus)
RHEA:36626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + S-adenosyl-L-methionine <=> (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Canis familiaris)
RHEA:46251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Mus musculus)
REACT:R-SSC-159868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor VII to factor VII (Sus scrofa)
RHEA:15767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide phosphate + GDP + H(+) => adenosylcob(III)inamide + GTP
REACT:R-HSA-110011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Grb10 to the insulin receptor (Homo sapiens)
RHEA:58669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyfructose + NADP(+) => 3-deoxyglucosone + H(+) + NADPH
RHEA:61132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + kaempferol + succinate
RHEA:10712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O
RHEA:10712	skos:altLabel	"phenylalanine (deaminating, decarboxylating) oxidase"
RHEA:10712	skos:prefLabel	"phenylalanine 2-monooxygenase"
RHEA:10712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine 2-monooxygenase"
RHEA:10712	skos:altLabel	"L-phenylalanine oxidase (deaminating and decarboxylating)"
REACT:R-CFA-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Canis familiaris)
REACT:R-SSC-8864036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates PDGFRB at Y1021 (Sus scrofa)
RHEA:26345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactonate + NADP(+) = aldehydo-D-galacturonate + H(+) + NADPH
RHEA:26345	skos:prefLabel	"D-galacturonate reductase"
RHEA:26345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-galacturonate reductase"
RHEA:26345	skos:altLabel	"GalUR"
REACT:R-CEL-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:68215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA
RHEA:29901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-xylose(in) + H(+) + phosphate => ATP + D-xylose(out) + H2O
REACT:R-SSC-9032751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Sus scrofa)
RHEA:34711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphing-4-enine = 15-methylhexadecasphing-4-enine + a fatty acid
REACT:R-MMU-112435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin BC complex (Mus musculus)
REACT:R-RNO-9690493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors on endosomes (Rattus norvegicus)
REACT:R-BTA-6804383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 methylates TP53 (Bos taurus)
REACT:R-MMU-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Mus musculus)
EC:2.6.3.-	skos:prefLabel	"Oximinotransferases"
EC:2.6.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Oximinotransferases"
RHEA:49347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:59811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine <=> D-tyrosine
REACT:R-DRE-5654705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
GO:0010854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylate cyclase regulator activity
REACT:R-HSA-72130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of an intermediate Spliceosomal C complex (Homo sapiens)
REACT:R-DRE-2471621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin degradation by cathepsins (Danio rerio)
REACT:R-GGA-2168889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin-related Protein binds Hemoglobin (Gallus gallus)
GO:0102608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracenomycin B3 8-O-methyl transferase activity
REACT:R-DDI-76052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIA To type 1 Promoter (Dictyostelium discoideum)
RHEA:24790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate
RHEA:62152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + dTTP = dGDP + dTDP
REACT:R-CEL-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Caenorhabditis elegans)
RHEA:39788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9615490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S133-CREB1 binds MIR132 gene promoter (Homo sapiens)
RHEA:15070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-devinyl-3-(1-hydroxyethyl)chlorophyllide a => chlorophyllide a + H2O
REACT:R-MMU-2168886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemopexin binds Hemes (Mus musculus)
REACT:R-DRE-8862137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B2 oxidises estradiol (E2) to estrone (E1) (Danio rerio)
RHEA:13311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + vanillate => H2O + NAD(+) + vanillin
RHEA:17665	skos:altLabel	"lipoate/octanoate transferase"
RHEA:17665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipoyl(octanoyl) transferase"
RHEA:17665	skos:prefLabel	"lipoyl(octanoyl) transferase"
RHEA:17665	skos:altLabel	"lipoyl (octanoyl)-[acyl-carrier-protein]-protein N-lipoyltransferase"
RHEA:17665	skos:altLabel	"lipoyl(octanoyl)transferase"
RHEA:17665	skos:altLabel	"octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase"
RHEA:17665	skos:altLabel	"lipoyltransferase"
RHEA:17665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]
RHEA:41051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA
REACT:R-HSA-9017835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 coactivator complex binds NOTCH3 gene (Homo sapiens)
RHEA:70658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + sarcosine(in) <=> H(+)(out) + sarcosine(out)
REACT:R-CFA-9667569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,2 bind AVPR antagonists (Canis familiaris)
REACT:R-MMU-4608855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRICKLE1 is degraded by the proteasome (Mus musculus)
RHEA:56878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-phenylethylamine + acetate => (R)-N-acetyl-1-phenylethylamine + H2O
RHEA:40769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg1 + D-xylose => (20S)-ginsenoside R1 + H2O
REACT:R-RNO-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)
REACT:R-SSC-1237325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A is protonated and carbamated causing release of oxygen (Sus scrofa)
REACT:R-CFA-936951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to activated TLR4 complex (Canis familiaris)
RHEA:52520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Caenorhabditis elegans)
REACT:R-GGA-2424243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Gallus gallus)
REACT:R-DME-159101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Drosophila melanogaster)
REACT:R-HSA-71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Homo sapiens)
RHEA:67048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chermesin D + O2 = A + asnovolin I + H2O
REACT:R-HSA-176175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Stalling of DNA replication fork and RPA binding (Homo sapiens)
RHEA:32289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-isopropylmalate => (2R,3S)-3-isopropylmalate
RHEA:25615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terpentedienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
RHEA:67766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-BTA-399711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca impermeable AMPA receptors (Bos taurus)
RHEA:19358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-proline betaine + NADPH + O2 => formaldehyde + H2O + N-methyl-L-proline + NADP(+)
GO:0034795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butane monooxygenase activity
GO:0034795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane hydroxylase activity
GO:0034795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane monooxygenase activity
REACT:R-GGA-8937369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAD2 binds ESR1 (Gallus gallus)
REACT:R-DRE-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Danio rerio)
RHEA:52327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-arginine + 4 O2 + 3 reduced [flavodoxin] <=> 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]
REACT:R-RNO-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Rattus norvegicus)
REACT:R-DRE-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Danio rerio)
RHEA:43317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
GO:0008797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate ammonia-lyase activity
GO:0008797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate ammonia-lyase (fumarate-forming)
GO:0008797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fumaric aminase activity
GO:0008797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartase activity
GO:0008797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartase activity
GO:0008797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate ammonia-lyase activity
RHEA:72626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base <=> a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base
RHEA:25720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-trihomomethionine => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O
REACT:R-MMU-9756183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Mus musculus)
RHEA:13499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+) => 5-dehydro-2-deoxy-D-gluconate + ATP
RHEA:35967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fumitremorgin C monooxygenase"
RHEA:35967	skos:prefLabel	"fumitremorgin C monooxygenase"
RHEA:35967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:18374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)
REACT:R-RNO-1981157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of collagen propeptide hydroxylysines (Rattus norvegicus)
REACT:R-XTR-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Xenopus tropicalis)
RHEA:57318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+) => ATP + cytidine 5'-diphosphoramidate
REACT:R-GGA-4551661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates RNF168 with SUMO1 (Gallus gallus)
REACT:R-BTA-5684862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Bos taurus)
REACT:R-MTU-9635428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FadD26, FadD28 transfer LCFA adenylate ester to Pks5 (Mycobacterium tuberculosis)
GO:0050105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-gulono-gamma-lactone:oxidoreductase activity
GO:0050105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GLO activity
GO:0050105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-gulono-gamma-lactone:O2 oxidoreductase activity
GO:0050105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-gulono-gamma-lactone oxidase activity
GO:0050105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonolactone oxidase activity
GO:0050105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity
RHEA:31388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => alpha-amyrin
RHEA:26489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-phospho-L-serine + sulfite <=> L-cysteate + phosphate
RHEA:10199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate <=> 2-succinylbenzoate + H2O
REACT:R-DDI-8877311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB31 GEFs exchange GTP for GDP on RAB31 (Dictyostelium discoideum)
RHEA:50338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate
REACT:R-HSA-9603801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds PEX3 (Homo sapiens)
REACT:R-BTA-8874745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Bos taurus)
REACT:R-GGA-353526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair of ~27-30 bp long patch by DNA Pol Epsilon (Gallus gallus)
REACT:R-RNO-5195402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LPIN (Rattus norvegicus)
RHEA:30916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine
REACT:R-RNO-5676589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANKL,sRANKL trimer binds RANK (Rattus norvegicus)
REACT:R-XTR-8848215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Xenopus tropicalis)
GO:0106268	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DIF-1 syntase
GO:0106268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine
GO:0106268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dichloro-THPH methyl transferase activity
RHEA:29296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galacturonate(out) + H(+)(out) => aldehydo-D-galacturonate(in) + H(+)(in)
REACT:R-GGA-353516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of DNA at sites of patch replacement (Gallus gallus)
REACT:R-CFA-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Canis familiaris)
GO:0001531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-21 receptor binding
GO:0001531	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-21 receptor ligand
GO:0001531	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-21
REACT:R-SSC-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Sus scrofa)
GO:0035615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clathrin-associated adaptor activity
GO:0035615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clathrin adaptor activity
RHEA:46652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone + H(+) + NADPH = 5beta-dihydroepitestosterone + NADP(+)
REACT:R-MMU-389381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gads binds CD28 (Mus musculus)
REACT:R-SSC-6784959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPHL hydrolyses VACV to ACV (Sus scrofa)
REACT:R-MMU-2213236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Mus musculus)
RHEA:37947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O
RHEA:68293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + nonanoyl-CoA => CoA + O-nonanoyl-L-seryl-[protein]
REACT:R-SSC-266315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + spherical HDL <=> LCAT:spherical HDL complex (Sus scrofa)
REACT:R-DRE-912527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 mediates cytokine-induced phosphorylation of GAB2 (Danio rerio)
REACT:R-DRE-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Danio rerio)
REACT:R-DRE-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Danio rerio)
REACT:R-BTA-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructoaldolase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose-1,6-bisphosphate triosephosphate-lyase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 1-monophosphate aldolase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SMALDO
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 1-phosphate aldolase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aldolase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 1,6-diphosphate aldolase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketose 1-phosphate aldolase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphofructoaldolase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zymohexase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,6-diphosphofructose aldolase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose-bisphosphate aldolase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose diphosphate aldolase activity
GO:0004332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphofructose aldolase activity
REACT:R-CFA-5674130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Canis familiaris)
REACT:R-MMU-3361751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin is replaced by repression complexes at the promoter (Mus musculus)
REACT:R-DRE-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Danio rerio)
REACT:R-GGA-8943987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCUBE1, SCUBE3 oligomerize (Gallus gallus)
REACT:R-CFA-622310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD1 oligomerizes (Canis familiaris)
RHEA:62536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]
REACT:R-DDI-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Dictyostelium discoideum)
RHEA:63072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + orcinol
GO:0004949	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endocannabinoid receptor activity
GO:0004949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannaboid receptor
GO:0004949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabinoid receptor activity
RHEA:60827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate <=> 2 AMP + 2 H(+)
REACT:R-HSA-8944214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type I (Homo sapiens)
EC:2.3.1.142	skos:prefLabel	"glycoprotein O-fatty-acyltransferase"
EC:2.3.1.142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycoprotein O-fatty-acyltransferase"
GO:0097079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenite:H+ symporter activity
GO:0097079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenite:proton symporter activity
GO:0097079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenite:hydrogen symporter activity
REACT:R-SSC-373813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR2 binds ligands CXCL1 to 7 (Sus scrofa)
REACT:R-DRE-140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor V -> factor Va + factor V activation peptide (Danio rerio)
RHEA:41344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate
REACT:R-HSA-1839067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BCR moiety of BCR-FGFR1 (Homo sapiens)
REACT:R-DRE-9734475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds fibrates (Danio rerio)
RHEA:19630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH
RHEA:63582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxyecdysone + phosphate => 20-hydroxyecdysone 22-phosphate + H2O
RHEA:47342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:57945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + harderoheme III => CO2 + 2 H2O + heme b
RHEA:40992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + H2O => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA
GO:0097153	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	caspase activity
GO:0097153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type endopeptidase activity involved in apoptotic process
GO:0097153	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metacaspase activity
GO:0097153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome activates CASP2 (Homo sapiens)
REACT:R-RNO-9005980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 binds IL21R:JAK1 (Rattus norvegicus)
REACT:R-DME-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Drosophila melanogaster)
RHEA:29694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltotetraose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotriose
REACT:R-BTA-212356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL-NICD coactivator complex (Bos taurus)
RHEA:64337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 malonyl-CoA + nicotinyl-CoA => 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA
RHEA:67243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-adenosyl-L-methionine + H2O <=> adenosine + H(+) + L-methionine
RHEA:43537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-glyceraldehyde 3-phosphate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate
REACT:R-BTA-201603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of PKC theta (Bos taurus)
RHEA:37864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA => 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CEL-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)
REACT:R-HSA-5628807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol (Homo sapiens)
GO:0047690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartotransferase activity
GO:0047690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartyltransferase activity
GO:0047690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-asparagine:hydroxylamine gamma-aspartyltransferase activity
GO:0047690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-aspartyl transferase activity
RHEA:25565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-4-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate
RHEA:66736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-citrylglutamate(in) + H2O = ADP + beta-citrylglutamate(out) + H(+) + phosphate
REACT:R-SSC-5683588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 transfers ATG12 from ATG10 to ATG5 (Sus scrofa)
EC:2.4.1.30	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,3-beta-oligoglucan phosphorylase"
EC:2.4.1.30	skos:altLabel	"beta-1,3-oligoglucan:orthophosphate glucosyltransferase II"
EC:2.4.1.30	skos:prefLabel	"1,3-beta-oligoglucan phosphorylase"
REACT:R-HSA-77585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Homo sapiens)
REACT:R-RNO-975311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Rattus norvegicus)
REACT:R-CFA-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Canis familiaris)
RHEA:15262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-1981128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Bos taurus)
REACT:R-HSA-2046084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Homo sapiens)
REACT:R-MMU-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Mus musculus)
RHEA:43166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-carbaguanosine(15) in tRNA + guanine => 7-cyano-7-deazaguanine + guanosine(15) in tRNA
RHEA:47644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine
REACT:R-HSA-6814674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)
REACT:R-DME-432411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination (Drosophila melanogaster)
RHEA:66213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-omegaC5-CoA + O2 => asc-omegaDeltaC5-CoA + H2O2
GO:0017096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyindole methyltransferase activity
GO:0017096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylserotonin O-methyltransferase activity
GO:0017096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyindole O-methyltransferase activity
GO:0017096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylserotonin methyltransferase activity
GO:0017096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylserotonin O-methyltransferase activity
GO:0017096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity
REACT:R-HSA-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Homo sapiens)
RHEA:51779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlorisobutanophenone + dimethylallyl diphosphate <=> deoxycohumulone + diphosphate
RHEA:11901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-homoisocitrate + NAD(+) => 2-oxoadipate + CO2 + NADH
GO:0030554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenyl nucleotide binding
REACT:R-CFA-389639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Canis familiaris)
REACT:R-DME-6783177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates GATA3,IL33 (Drosophila melanogaster)
REACT:R-XTR-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-HSA-8950724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Homo sapiens)
REACT:R-DRE-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Danio rerio)
RHEA:43197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(4) in tRNA(His) + S-adenosyl-L-methionine => 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine
RHEA:22017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutaredoxin]-dithiol + arsenate + glutathione + H(+) => arsenite + glutathionyl-S-S-[glutaredoxin] + H2O
RHEA:28238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calycosin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin
RHEA:31387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = alpha-amyrin
RHEA:31387	skos:altLabel	"2,3-oxidosqualene alpha-amyrin cyclase"
RHEA:31387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-amyrin synthase"
RHEA:31387	skos:prefLabel	"alpha-amyrin synthase"
RHEA:41193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O
RHEA:41801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-CFA-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Canis familiaris)
REACT:R-SSC-6791109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds PCNA (Sus scrofa)
RHEA:70436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 => a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate
REACT:R-DME-2064406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Drosophila melanogaster)
RHEA:28553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + anthranilate <=> CoA + N-acetylanthranilate
RHEA:72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 = 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)
RHEA:48308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)
RHEA:48308	skos:altLabel	"benzoyl-CoA-dihydrodiol lyase"
RHEA:48308	skos:prefLabel	"2,3-epoxybenzoyl-CoA dihydrolase"
RHEA:48308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-epoxybenzoyl-CoA dihydrolase"
RHEA:48308	skos:altLabel	"dihydrodiol transforming enzyme"
REACT:R-CEL-264458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of COP1 (Caenorhabditis elegans)
REACT:R-RNO-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
REACT:R-SSC-9679028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 binds JAK3 inhibitors (Sus scrofa)
REACT:R-MMU-400677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rnd1 interacts with Plexin-B1:Sema4D (Mus musculus)
RHEA:50796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin A2 = prostaglandin A2-S-(R)-glutathione
REACT:R-CFA-5138441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A-FZD4 recruits DVL2 (Canis familiaris)
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitochondrial N-terminal peptidyl-methionine N-formylation
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionyl-tRNA transformylase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionyl-transfer ribonucleic transformylase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionyl ribonucleic formyltransferase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylmethionyl-transfer ribonucleic synthetase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionyl-tRNA Met formyltransferase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	conversion of mitochondrial met-tRNAf to fmet-tRNA
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionyl-transfer RNA transformylase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	conversion of met-tRNAf to fmet-tRNA
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionyl-tRNA formyltransferase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionyl-transfer ribonucleate methyltransferase activity
GO:0004479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-terminal peptidyl-methionine N-formylation
REACT:R-HSA-6788684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT13 2'-O-methylates cytidine-4 in tRNA (Homo sapiens)
REACT:R-MMU-9018907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Mus musculus)
RHEA:43754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5]
EC:3.2.1.64	skos:altLabel	"2,6-beta-D-fructan 6-levanbiohydrolase"
EC:3.2.1.64	skos:prefLabel	"2,6-beta-fructan 6-levanbiohydrolase"
EC:3.2.1.64	skos:altLabel	"levanbiose-producing levanase"
EC:3.2.1.64	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,6-beta-fructan 6-levanbiohydrolase"
EC:3.2.1.64	skos:altLabel	"beta-2,6-fructan-6-levanbiohydrolase"
EC:3.2.1.64	skos:altLabel	"2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase"
RHEA:44194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexadecanoyl-CoA + AMP + diphosphate => 2-methylhexadecanoate + ATP + CoA
REACT:R-HSA-8847875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF1:GTP binds Golgin TRIP11 (Homo sapiens)
REACT:R-DME-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Drosophila melanogaster)
REACT:R-SSC-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Sus scrofa)
REACT:R-HSA-443926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)
REACT:R-PFA-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Plasmodium falciparum)
RHEA:10181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + H2O + NADP(+) => (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH
RHEA:62733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide D + FADH2
RHEA:14627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n) => [(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1)
REACT:R-CEL-3322016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Caenorhabditis elegans)
RHEA:35778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + UDP-3-oxo-alpha-D-glucose <=> 2-oxoglutaramate + UDP-alpha-D-kanosamine
REACT:R-HSA-5629189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates expression of SESN1,2,3 genes (Homo sapiens)
REACT:R-CFA-5362459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)
REACT:R-BTA-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)
REACT:R-BTA-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)
REACT:R-PFA-5696197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Plasmodium falciparum)
RHEA:30122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-[ACP] + H2O <=> dodecanoate + H(+) + holo-[ACP]
REACT:R-XTR-9679477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFA inhibitors (Xenopus tropicalis)
RHEA:65933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine => 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine
RHEA:28123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + di-trans,octa-cis-undecaprenol => ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)
GO:0034545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylpyruvate hydrolase activity
GO:0034545	skos:prefLabel	"3-fumarylpyruvate hydrolase"
GO:0034545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-fumarylpyruvate hydrolase"
GO:0034545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-fumarylpyruvate + H2O = fumarate + H(+) + pyruvate
REACT:R-MMU-5618085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)
RHEA:60583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:20152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + quinine + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-8874470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Canis familiaris)
REACT:R-CEL-353125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteosome degrades ODC holoenzyme complex (Caenorhabditis elegans)
REACT:R-CFA-140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Canis familiaris)
REACT:R-CEL-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Caenorhabditis elegans)
REACT:R-HSA-376121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bnip2 interacts with CDO complex (Homo sapiens)
RHEA:23882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + pyruvate => L-histidyl-[protein] + phosphoenolpyruvate
RHEA:13528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]
REACT:R-GGA-445757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1 receptor antagonist protein binds Interleukin 1 receptors (Gallus gallus)
REACT:R-MMU-2213241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of nonameric complex (Mus musculus)
REACT:R-RNO-1855162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Rattus norvegicus)
REACT:R-SPO-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Schizosaccharomyces pombe)
GO:0106291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 O2 = H(+) + NAD(+) + 2 superoxide
GO:0106291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	superoxide-generating NADH oxidase activity.
RHEA:34262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-larreatricin + AH2 + O2 <=> (+)-3'-hydroxylarreatricin + A + H2O
REACT:R-SSC-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Sus scrofa)
REACT:R-HSA-399938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by FARP2 (Homo sapiens)
RHEA:10339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> D-threo-isocitrate
REACT:R-RNO-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Rattus norvegicus)
RHEA:34914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methionine(in) <=> D-methionine(out)
GO:0031489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin V binding
REACT:R-SSC-2187388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Sus scrofa)
GO:0034574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	didemethylisoproturon dehydrogenase activity
REACT:R-DME-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Drosophila melanogaster)
REACT:R-RNO-5578783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Rattus norvegicus)
REACT:R-DME-156808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Drosophila melanogaster)
GO:0005344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxygen carrier activity
GO:0005344	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hemocyanin
GO:0005344	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hemerythrin
GO:0005344	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	globin
GO:0005344	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxygen-carrying
RHEA:72110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-acyl-(R)-carnitine(out) <=> Na(+)(in) + O-acyl-(R)-carnitine(in)
REACT:R-HSA-2730872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Calcineurin (Homo sapiens)
RHEA:29287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + L-aspartate(in) = 2 H(+)(out) + L-aspartate(out)
REACT:R-MMU-74742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 (Mus musculus)
REACT:R-MMU-9704248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM4 binds CHRM4 antagonists (Mus musculus)
REACT:R-HSA-975125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
RHEA:25485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (1S,4R)-camphene + diphosphate
REACT:R-DME-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Drosophila melanogaster)
RHEA:37717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine
REACT:R-HSA-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Homo sapiens)
REACT:R-XTR-2066787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Xenopus tropicalis)
RHEA:20338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-O-sulfolactate + H2O => (R)-lactate + H(+) + sulfate
REACT:R-HSA-392874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
GO:0050128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-feruloylglycine amidohydrolase activity
GO:0050128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-feruloylglycine deacylase activity
GO:0050128	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-feruloylglycine hydrolase activity
REACT:R-CFA-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Canis familiaris)
REACT:R-DRE-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Danio rerio)
RHEA:42309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:12946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxybiphenyl-2-sulfinate + H2O => biphenyl-2-ol + H(+) + sulfite
REACT:R-MMU-982792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor binds JAK2 (Mus musculus)
REACT:R-HSA-1855201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 transports from the cytosol to the nucleus (Homo sapiens)
REACT:R-HSA-5387392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	processing defective Hh variants are degraded by the proteasome (Homo sapiens)
REACT:R-DME-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Drosophila melanogaster)
REACT:R-XTR-8941628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
REACT:R-GGA-3296126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Gallus gallus)
REACT:R-HSA-2161660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGE2 by PTGES (Homo sapiens)
RHEA:60932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:50249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + diphosphate
RHEA:50772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nitroethane + O2 = acetaldehyde + H(+) + H2O2 + nitrite
GO:0034800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trinitrophenol dihydride denitratase activity
GO:0034800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trinitrophenol dihydride denitratase activity
GO:0034800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNP dihydride denitratase activity
REACT:R-BTA-8874083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y397-PTK2 binds SRC (Bos taurus)
RHEA:63189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + AH2 + tyramine => A + H2O + norbelladine
RHEA:19678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9'-cis-neoxanthin + O2 => (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin
REACT:R-CEL-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)
RHEA:42165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O
RHEA:68618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + NADP(+) => cortisone + H(+) + NADPH
REACT:R-HSA-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
REACT:R-BTA-210291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Bos taurus)
REACT:R-DRE-71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Danio rerio)
REACT:R-DRE-5694445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH1 binds TFGA and AREG precursors (Danio rerio)
RHEA:34701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-alpha-isocomene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-SSC-5226964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKH transports PPi from cytosol to extracellular region (Sus scrofa)
REACT:R-HSA-5654409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS2 (Homo sapiens)
REACT:R-DME-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Drosophila melanogaster)
RHEA:28369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate <=> beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:30906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylspheroidene + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + spheroidene
REACT:R-DDI-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Dictyostelium discoideum)
REACT:R-MMU-1606602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Mus musculus)
RHEA:30475	skos:prefLabel	"baicalin-beta-D-glucuronidase"
RHEA:30475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"baicalin-beta-D-glucuronidase"
RHEA:30475	skos:altLabel	"baicalinase"
RHEA:30475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oroxylin A 7-O-beta-D-glucuronate = D-glucuronate + H(+) + oroxylin A
REACT:R-DME-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Drosophila melanogaster)
REACT:R-MMU-1168644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Mus musculus)
RHEA:27492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-sedoheptulose 7-phosphate <=> D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate
RHEA:21117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose + phosphate => beta-D-glucose 1-phosphate + D-glucose
RHEA:54117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + pseudolaratriene
RHEA:21446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + trans-2-coumarate => 3-(2-hydroxyphenyl)propanoate + NAD(+)
REACT:R-DRE-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Danio rerio)
REACT:R-MMU-5617816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A  (Mus musculus)
REACT:R-RNO-8963864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN dissociates from 25(OH)D (Rattus norvegicus)
RHEA:13441	skos:prefLabel	"L-cysteate sulfo-lyase"
RHEA:13441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-cysteate sulfo-lyase"
RHEA:13441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteate = H(+) + NH4(+) + pyruvate + sulfite
REACT:R-XTR-3769447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex deacetylate histones (Xenopus tropicalis)
REACT:R-DRE-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Danio rerio)
REACT:R-BTA-9632868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1B is phosphorylated in response to estrogen (Bos taurus)
REACT:R-XTR-877198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates membrane pores that include pannexin-1 (Xenopus tropicalis)
REACT:R-GGA-5687120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Gallus gallus)
REACT:R-SSC-2022141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolysyl oxidase activation (Sus scrofa)
REACT:R-SSC-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Sus scrofa)
RHEA:52046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + mogroside IE + UDP => mogrol + UDP-alpha-D-glucose
REACT:R-CFA-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Canis familiaris)
RHEA:43514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-5-formylfuran + H(+) + H2O2 => 2-(dihydroxymethyl)-5-formylfuran + O2
RHEA:36486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA
REACT:R-MMU-5340124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSN polymer binds CaPO4 (Mus musculus)
REACT:R-MMU-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Mus musculus)
REACT:R-DME-210430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of L-Glutamate at the synapse (Drosophila melanogaster)
RHEA:70183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 alpha-isomaltosyl-(1->4)-D-maltotriose = alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose
RHEA:72187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + sucrose(out) = H(+)(in) + sucrose(in)
RHEA:49390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + UDP + validamycin A => UDP-alpha-D-glucose + validoxylamine A
RHEA:33801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-histidinal + NADH => L-histidinol + NAD(+)
GO:0046405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol dehydrase activity
GO:0046405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol hydro-lyase activity
GO:0046405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol dehydratase activity
GO:0046405	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol hydro-lyase (3-hydroxypropanal-forming)
REACT:R-DRE-76475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Danio rerio)
RHEA:58439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentan-1-ol + NADP(+) <=> 4-methylpentanal + H(+) + NADPH
REACT:R-RNO-202144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Rattus norvegicus)
RHEA:70009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzoyl-AMP + diphosphate => anthranilate + ATP + H(+)
RHEA:37898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + protodioscin <=> 26-deglucoprotodioscin + D-glucose
REACT:R-RNO-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Rattus norvegicus)
REACT:R-DDI-9033520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYSND1 cleaves TYSND1 (Dictyostelium discoideum)
REACT:R-MMU-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Mus musculus)
REACT:R-PFA-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Plasmodium falciparum)
REACT:R-DDI-1855219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
REACT:R-XTR-140769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VII -> factor VIIa (Xenopus tropicalis)
REACT:R-GGA-8847977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRK phosphorylates PTEN (Gallus gallus)
REACT:R-BTA-8869627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NR to yield NMN (Bos taurus)
RHEA:33908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(methylamino)butanoate + H2O + O2 => 4-aminobutanoate + formaldehyde + H2O2
REACT:R-HSA-175117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-LTR circle formation (Homo sapiens)
GO:0030171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated proton channel activity
GO:0030171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage gated proton channel activity
GO:0030171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent proton channel activity
REACT:R-DME-5654634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates SHC1 (Drosophila melanogaster)
GO:0030729	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetate:CoA ligase (AMP-forming)
GO:0030729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate-CoA ligase activity
GO:0030729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA synthetase activity
GO:0030729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)
REACT:R-RNO-9624778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD 12mer translocates from ER membrane to extracellular region (Rattus norvegicus)
RHEA:45481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-hexachlorocyclohexane => (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)
REACT:R-RNO-6788582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 phosphorylation (Rattus norvegicus)
REACT:R-BTA-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
REACT:R-CFA-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Canis familiaris)
RHEA:43193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine
REACT:R-SCE-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Saccharomyces cerevisiae)
RHEA:61108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:69827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Drosophila melanogaster)
RHEA:71070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-phenylalanine(out) <=> L-arginine(out) + L-phenylalanine(in)
REACT:R-HSA-9761900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HBV X protein binds SQSTM1 oligomer (Homo sapiens)
REACT:R-PFA-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)
REACT:R-DRE-264678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Danio rerio)
REACT:R-BTA-9707051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN1 binds BRCA1:BARD1 heterodimer (Bos taurus)
REACT:R-RNO-158750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Rattus norvegicus)
RHEA:58829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10R)-epoxy-octadecanoate + H2O => 9R,10R-dihydroxyoctadecanoate
REACT:R-CFA-5676595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAFs bind RANK:RANKL (Canis familiaris)
RHEA:69183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + thiamine diphosphate <=> AMP + thiamine triphosphate
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tau protein kinase activity
GO:0050321	skos:altLabel	"protein tau kinase"
GO:0050321	skos:altLabel	"glycogen synthase kinase-3beta"
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein tau kinase activity
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cdk5/p20
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tau-protein kinase II activity
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GSK
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK31
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TTK
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPK II
GO:0050321	skos:altLabel	"TPK"
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tau-protein kinase activity
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Tau protein] kinase activity
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen synthase kinase-3beta activity
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tau-tubulin kinase activity
GO:0050321	skos:altLabel	"GSK"
GO:0050321	skos:altLabel	"TTK"
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPK I
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tau kinase activity
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDK5/p23
GO:0050321	skos:altLabel	"[tau-protein] kinase"
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP:tau-protein O-phosphotransferase activity
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[tau protein] kinase"
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	brain protein kinase PK40erk activity
GO:0050321	skos:altLabel	"tau kinase"
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tau-protein kinase I activity
GO:0050321	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TPK
GO:0050321	skos:prefLabel	"[tau protein] kinase"
GO:0050321	skos:altLabel	"tau-tubulin kinase"
REACT:R-DME-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Drosophila melanogaster)
RHEA:44754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine
REACT:R-HSA-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)
REACT:R-DRE-2454192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Allergen dependent IgE bound FCERI aggregation (Danio rerio)
REACT:R-BTA-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Bos taurus)
REACT:R-CFA-5693620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop formation mediated by PALB2, BRCA2 and RAD51 (Canis familiaris)
RHEA:63580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxyecdysone 22-phosphate + H2O = 20-hydroxyecdysone + phosphate
RHEA:26176	skos:altLabel	"MshC ligase"
RHEA:26176	skos:prefLabel	"L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase"
RHEA:26176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase"
RHEA:26176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)
RHEA:26176	skos:altLabel	"mycothiol ligase"
RHEA:39115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH
REACT:R-GGA-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
GO:0072550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triferuloylspermidine meta-hydroxylase activity
GO:0072550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triferuloyl spermidine meta-hydroxylase activity
REACT:R-SSC-416698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA5A binds to PLXNB3 (Sus scrofa)
GO:0005109	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	frizzled-2 ligand
GO:0005109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fz binding
GO:0005109	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	frizzled ligand
GO:0005109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	frizzled binding
GO:0005109	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	frizzled-2 binding
GO:0005109	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fz ligand
GO:0005109	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fz2 ligand
GO:0005109	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fz2 binding
RHEA:28310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase"
RHEA:28310	skos:prefLabel	"GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase"
RHEA:28310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
RHEA:41253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
RHEA:29121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H2O + nitrite => a ubiquinol + nitrate
REACT:R-BTA-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Bos taurus)
RHEA:38003	skos:altLabel	"HGGT"
RHEA:38003	skos:prefLabel	"homogentisate geranylgeranyltransferase"
RHEA:38003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate = 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate
RHEA:38003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homogentisate geranylgeranyltransferase"
REACT:R-HSA-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Homo sapiens)
RHEA:35697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH => (3S)-versiconol acetate + NADP(+)
RHEA:25026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + S-methyl-5'-thioadenosine => NH4(+) + S-methyl-5'-thioinosine
REACT:R-CFA-9634861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT2 (Canis familiaris)
REACT:R-HSA-2399981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates MDM2 (Homo sapiens)
RHEA:36116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A3 + S-adenosyl-L-methionine => O-methyl gibberellin A3 + S-adenosyl-L-homocysteine
RHEA:27474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glycero-beta-D-manno-heptose 7-phosphate => ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)
RHEA:69381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-methylpentanoate + O2 => 4-methyl-2-oxopentanoate + H2O2
REACT:R-MMU-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Mus musculus)
REACT:R-HSA-2466832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA (Homo sapiens)
RHEA:23327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-phospho-[ligated tRNA] + NAD(+) <=> ADP-beta-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide
RHEA:29114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + ubiquinone-8 <=> NADP(+) + ubiquinol-8
RHEA:66100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + L-kynurenine = H2O + kynurenate + L-tyrosine
REACT:R-SSC-2046097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)
REACT:R-SSC-9014741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer deaminates D-Ser (Sus scrofa)
REACT:R-MMU-3928645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB:NMDAR binds TIAM1 (Mus musculus)
RHEA:47910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-gluconate + H(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O
RHEA:26015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7-dideoxy-D-threo-hepto-2,6-diuolosonate => 3-dehydroquinate
REACT:R-HSA-211476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF1A-dependent synthesis of GLUT2 protein (Homo sapiens)
REACT:R-PFA-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Plasmodium falciparum)
RHEA:35522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine
RHEA:69715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + ATP + CoA = (indol-3-yl)acetyl-CoA + AMP + diphosphate
REACT:R-SSC-8867370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Sus scrofa)
REACT:R-GGA-917839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-Transferrin dissociates from the receptor complex (Gallus gallus)
REACT:R-SSC-376369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp2 associated secretory vesicle to plasma membrane transport (Sus scrofa)
REACT:R-MMU-8952625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Mus musculus)
GO:0043881	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mch
GO:0043881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylmalyl-CoA dehydratase activity
GO:0043881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mesaconyl-coenzyme A hydratase activity
GO:0043881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mesaconyl-CoA hydratase activity
REACT:R-DME-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Drosophila melanogaster)
RHEA:66434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-galactose(in) => H(+)(out) + L-galactose(out)
RHEA:17997	skos:prefLabel	"cobalt-factor II C(20)-methyltransferase"
RHEA:17997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobalt-factor II C(20)-methyltransferase"
RHEA:17997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-2 + S-adenosyl-L-methionine = Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine
RHEA:17997	skos:altLabel	"Cobalt-precorrin-2 C(20)-methyltransferase"
RHEA:69938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(out) + Na(+)(out) <=> guanosine(in) + Na(+)(in)
REACT:R-HSA-6809254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR8 binds MTMR9 (Homo sapiens)
RHEA:28928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate + O2 => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)
REACT:R-HSA-6803836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b-specific alternative splicing produces FGFR2b transcript (Homo sapiens)
GO:0008951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoleoyl ACP-dependent acyltransferase activity
GO:0008951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity
RHEA:50053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurocholate(in) => ADP + H(+) + phosphate + taurocholate(out)
RHEA:44795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-12 + S-adenosyl-L-methionine <=> H(+) + menaquinol-12 + S-adenosyl-L-homocysteine
RHEA:22545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
REACT:R-HSA-2730886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC by SYK kinase (Homo sapiens)
REACT:R-SSC-111746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Sus scrofa)
REACT:R-HSA-9617840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter (Homo sapiens)
REACT:R-HSA-6784436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An unknown carrier transports mitochondrial glyoxylate to the cytosol (Homo sapiens)
REACT:R-RNO-549297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:44491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-9026777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)
RHEA:46996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-N-methylmyosmine + H2O = 6-hydroxypseudooxynicotine
REACT:R-DME-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Drosophila melanogaster)
RHEA:55067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanoyl-CoA + H2O <=> 4-methylpentanoate + CoA + H(+)
REACT:R-BTA-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-HSA-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Homo sapiens)
RHEA:45603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexokinase D
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hexokinase type IV (glucokinase) activity
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hexokinase type III activity
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose ATP phosphotransferase activity
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexokinase type IV
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexokinase (phosphorylating)
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hexokinase type II activity
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent hexokinase activity
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexokinase type IV glucokinase activity
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hexokinase type I activity
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexokinase activity
GO:0004396	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-hexose 6-phosphotransferase activity
REACT:R-SSC-3239014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates TP53 (Sus scrofa)
RHEA:65872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,17beta-dihydroxyandrostan-3-one + A = 17beta-hydroxyandrostan-1,3-dione + AH2
REACT:R-BTA-199202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphopantetheine conjugation of the ACP domain of FAS (Bos taurus)
REACT:R-HSA-5607720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)
REACT:R-SSC-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Sus scrofa)
REACT:R-SSC-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Sus scrofa)
RHEA:43589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NORint + UDP-alpha-D-galactose => globoside NOR2 + H(+) + UDP
RHEA:13504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate
REACT:R-CFA-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Canis familiaris)
REACT:R-DRE-9021596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane estrogen receptors bind SRC (Danio rerio)
REACT:R-MMU-422051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the signal peptide of Preproghrelin (Mus musculus)
REACT:R-SSC-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Sus scrofa)
RHEA:52276	skos:prefLabel	"vanillate/3-O-methylgallate O-demethylase"
RHEA:52276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vanillate/3-O-methylgallate O-demethylase"
RHEA:52276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + vanillate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate
RHEA:52276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate
RHEA:31264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	but-3-ynal + H(+) + pyrroloquinoline quinol => but-3-yn-1-ol + pyrroloquinoline quinone
RHEA:67616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate + H(+)
REACT:R-HSA-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Homo sapiens)
REACT:R-MMU-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Mus musculus)
RHEA:12538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + L-phenylalanine => H(+) + L-arogenate
RHEA:35459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + NAD(+) = cholest-5-en-3-one + H(+) + NADH
RHEA:58438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylpentanal + H(+) + NADPH => 4-methylpentan-1-ol + NADP(+)
REACT:R-RNO-1475017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Rattus norvegicus)
REACT:R-BTA-6799777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind PPP1R13B or TP53BP2 (Bos taurus)
RHEA:64181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-tryptophan + H2O => a fatty acid + L-tryptophan
REACT:R-XTR-193737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Xenopus tropicalis)
GO:0120020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol carrier activity
GO:0120020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol transfer activity
GO:0120020	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cholesterol transporter activity
GO:0120020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane cholesterol transfer activity
REACT:R-CEL-3149494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC:cob(II)alamin binds MMADHC (Caenorhabditis elegans)
RHEA:71081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-1855205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)
GO:0015036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	disulphide oxidoreductase activity
GO:0015036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	disulfide oxidoreductase activity
RHEA:58979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonaldehyde + O2 <=> 3-oxopropanoate + H(+) + H2O2
RHEA:17041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + H2O = AMP + 2 H(+) + sulfate
RHEA:17041	skos:prefLabel	"adenylylsulfatase"
RHEA:17041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylylsulfatase"
REACT:R-HSA-2426147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds the FDPS promoter (Homo sapiens)
RHEA:58368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + H(+) + NADPH
REACT:R-SSC-6799199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Sus scrofa)
REACT:R-CFA-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)
RHEA:40354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-GGA-352867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose [cytosol] <=> glucose [extracellular] (Gallus gallus)
REACT:R-MMU-6807875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)
REACT:R-CEL-9718379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds chemical antagonists (Caenorhabditis elegans)
RHEA:34203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = aureusidin 6-O-beta-glucoside + H2O
RHEA:40323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:50820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = H(+) + NADPH + testosterone
REACT:R-CEL-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Caenorhabditis elegans)
REACT:R-MMU-8852010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL2 binds activated T cells surface (Mus musculus)
GO:0140272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exogenous protein binding
REACT:R-MMU-2424484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BTK by p-SYK (Mus musculus)
REACT:R-DRE-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Danio rerio)
REACT:R-BTA-8854209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A binds JFC1 (Bos taurus)
RHEA:64648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH
RHEA:44399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-XTR-873921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of STAT1 to p-IFNGR1 (Xenopus tropicalis)
REACT:R-HSA-166753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C4 into C4a and C4b (Homo sapiens)
REACT:R-CEL-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Caenorhabditis elegans)
REACT:R-MMU-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Mus musculus)
RHEA:33495	skos:prefLabel	"heptaprenylglyceryl phosphate synthase"
RHEA:33495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heptaprenylglyceryl phosphate synthase"
RHEA:33495	skos:altLabel	"HepGP synthase"
RHEA:33495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate = 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate
RHEA:33495	skos:altLabel	"glycerol-1-phosphate heptaprenyltransferase"
RHEA:67082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acid(out) + ADP + H(+) + phosphate => a very long-chain fatty acid(in) + ATP + H2O
RHEA:31976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxusin => 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-9632034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GlcA to chondroitin (Xenopus tropicalis)
RHEA:35253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O
REACT:R-DRE-5686301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 binds SFTPAs (Danio rerio)
REACT:R-HSA-8950292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Heterogeneous nuclear ribonucleoproteins A2/B1 (Homo sapiens)
REACT:R-DDI-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Dictyostelium discoideum)
REACT:R-SSC-6805507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 binds AVEN (Sus scrofa)
REACT:R-DRE-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Danio rerio)
RHEA:72471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + D-threo-isocitrate(in) = citrate(in) + D-threo-isocitrate(out)
RHEA:46656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADPH = 5beta-androstane-3,17-dione + NADP(+)
REACT:R-CFA-170026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protons are translocated from the intermembrane space to the matrix (Canis familiaris)
REACT:R-CFA-444654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled bile acid receptor binds lithocholic acid (Canis familiaris)
REACT:R-BTA-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Bos taurus)
REACT:R-XTR-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Xenopus tropicalis)
RHEA:42007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH
REACT:R-XTR-3134953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 or DHX9 binds MyD88 (Xenopus tropicalis)
RHEA:44038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,13-dihydroxy-(9Z)-octadecenoate => 12,13-epoxy-(9Z)-octadecenoate + H2O
REACT:R-SPO-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Schizosaccharomyces pombe)
REACT:R-SSC-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Sus scrofa)
RHEA:18608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-amino-1-deoxy-scyllo-inositol + ATP <=> 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)
RHEA:51213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH
REACT:R-DRE-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)
RHEA:58330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-non-6-enal + H(+) + NADPH => (Z)-non-6-en-1-ol + NADP(+)
RHEA:12817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biochanin-A reductase"
RHEA:12817	skos:prefLabel	"biochanin-A reductase"
RHEA:12817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydrobiochanin A + NADP(+) = biochanin A + 2 H(+) + NADPH
REACT:R-RNO-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Rattus norvegicus)
REACT:R-HSA-4568848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)
RHEA:55225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:68192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + phytol = CoA + decanoate phytyl ester
REACT:R-CFA-6805109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates TP53 (Canis familiaris)
REACT:R-DRE-5692770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Danio rerio)
RHEA:10470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O => D-xylulose 5-phosphate + phosphate
REACT:R-CFA-5621355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Canis familiaris)
RHEA:37208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
RHEA:24539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 <=> N-formyl-L-kynurenine
REACT:R-DME-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Drosophila melanogaster)
GO:0004908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-1 receptor activity
GO:0004908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-1R
GO:0004908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1 receptor activity
REACT:R-DME-3697894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN2 (Drosophila melanogaster)
REACT:R-HSA-8851859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds RANBP9 and SOS1 (Homo sapiens)
GO:0102607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity
REACT:R-CFA-1474213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP1,8,9,13 (Canis familiaris)
REACT:R-SSC-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Sus scrofa)
RHEA:56960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + pyruvate = a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate
REACT:R-MMU-5625717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PKN1 binds androgen receptor (AR) (Mus musculus)
REACT:R-GGA-8849082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 stimulates RHOA GTPase activity (Gallus gallus)
REACT:R-SCE-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Saccharomyces cerevisiae)
REACT:R-DRE-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Danio rerio)
RHEA:20380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH
RHEA:19013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thymidine-triphosphatase"
RHEA:19013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP + H2O = dTDP + H(+) + phosphate
RHEA:19013	skos:prefLabel	"thymidine-triphosphatase"
RHEA:37950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O
REACT:R-CFA-5626223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Canis familiaris)
REACT:R-GGA-177935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)
REACT:R-RNO-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Rattus norvegicus)
RHEA:51493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate(in) <=> 4-(trimethylamino)butanoate(out)
RHEA:67541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine
RHEA:57038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose
REACT:R-HSA-114263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization  of BAK at the mitochondrial membrane (Homo sapiens)
REACT:R-MMU-77301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Mus musculus)
REACT:R-BTA-6811454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate PP2A (Bos taurus)
GO:0004745	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinal reductase activity
GO:0004745	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	all-trans retinol dehydrogenase activity
GO:0004745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-retinol dehydrogenase activity
GO:0004745	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinol dehydrogenase activity
GO:0004745	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinene reductase activity
GO:0004745	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinol (vitamin A1) dehydrogenase activity
REACT:R-SPO-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Schizosaccharomyces pombe)
REACT:R-SSC-6809003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERGIC-to-Golgi vesicles bind dynein:dynactin  (Sus scrofa)
REACT:R-HSA-927832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
REACT:R-DDI-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Dictyostelium discoideum)
REACT:R-HSA-3777129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC3 containing complexes deacetylate histone (Homo sapiens)
REACT:R-XTR-5649856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative damage to the AP site (Xenopus tropicalis)
REACT:R-RNO-4754176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR3-histone H3 (Rattus norvegicus)
RHEA:21945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-cellobiose => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)
RHEA:48463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate
GO:0005427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton-dependent oligopeptide transporter activity
GO:0005427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0005427	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen/oligopeptide symporter
REACT:R-HSA-443905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
REACT:R-HSA-6791109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds PCNA (Homo sapiens)
RHEA:65560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-kynurenine = H2O + kynurenate + L-glutamate
RHEA:65560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-hydroxy-L-kynurenine = H2O + L-glutamate + xanthurenate
RHEA:65560	skos:altLabel	"kynurenine aminotransferase"
RHEA:65560	skos:prefLabel	"kynurenine--oxoglutarate transaminase"
RHEA:65560	skos:altLabel	"kynurenine--oxoglutarate aminotransferase"
RHEA:65560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kynurenine--oxoglutarate transaminase"
REACT:R-SSC-9020259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Sus scrofa)
GO:0042826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone deacetylase binding
REACT:R-HSA-9759731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAI1 binds the OCLN gene (Homo sapiens)
REACT:R-HSA-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Homo sapiens)
REACT:R-BTA-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)
RHEA:29629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltoheptaose + beta-D-glucose => alpha-maltohexaose + beta-maltose
REACT:R-CFA-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Canis familiaris)
REACT:R-HSA-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Homo sapiens)
RHEA:21827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartate <=> L-glutamate + oxaloacetate
RHEA:68553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
RHEA:25570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + nicotinate beta-D-ribonucleotide => ATP + beta-D-ribosylnicotinate
GO:0004026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol O-acetyltransferase activity
GO:0004026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AATASE activity
GO:0004026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:alcohol O-acetyltransferase activity
GO:0004026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alcohol acetyltransferase activity
RHEA:52412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + NAD(+) = 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH
REACT:R-HSA-4084994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU3 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)
EC:3.4.21.64	skos:altLabel	"endopeptidase K"
EC:3.4.21.64	skos:altLabel	"Tritirachium album proteinase K"
EC:3.4.21.64	skos:altLabel	"proteinase K"
EC:3.4.21.64	skos:prefLabel	"peptidase K"
EC:3.4.21.64	skos:altLabel	"Tritirachium alkaline proteinase"
EC:3.4.21.64	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidase K"
REACT:R-SSC-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Sus scrofa)
REACT:R-HSA-1980233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Homo sapiens)
REACT:R-MMU-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Mus musculus)
GO:0050136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH dehydrogenase (quinone) activity
GO:0050136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPNH-menadione reductase activity
GO:0050136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-diaphorase activity
GO:0050136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-quinone oxidoreductase activity
GO:0050136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:(quinone-acceptor) oxidoreductase activity
GO:0050136	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity
REACT:R-CEL-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Caenorhabditis elegans)
REACT:R-MMU-1358798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 binds neuregulin-activated ERBB3 (Mus musculus)
RHEA:32277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2-oxopropyl phosphate + CO2 + NADH => 4-(phosphooxy)-L-threonine + NAD(+)
RHEA:64137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-asparagine => (9Z)-octadecenoate + L-asparagine
GO:0047260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose phosphate synthase (GDP-forming) activity
GO:0047260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity
GO:0047260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity
GO:0047260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-glucose-glucosephosphate glucosyltransferase activity
GO:0047260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPglucose-glucose-phosphate glucosyltransferase activity
GO:0047260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity
GO:0047260	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity
REACT:R-CFA-8854981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 in the RET complex is phosphorylated (Canis familiaris)
REACT:R-DRE-9020273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Danio rerio)
RHEA:67993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + trichloroethene => (Z)-1,2-dichloroethene + A + chloride + H(+)
RHEA:49453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O => 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol
REACT:R-XTR-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Xenopus tropicalis)
REACT:R-CFA-5607759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIKA2 binds K63polyUb-TRAF6 oligomer (Canis familiaris)
RHEA:14857	skos:altLabel	"IAA-lysine synthetase"
RHEA:14857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + ATP + L-lysine = ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate
RHEA:14857	skos:prefLabel	"indoleacetate--lysine synthetase"
RHEA:14857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indoleacetate--lysine synthetase"
RHEA:14857	skos:altLabel	"N-(indole-3-acetyl)-L-lysine synthetase"
REACT:R-GGA-8852716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin, ELANE cleave C5 (Gallus gallus)
RHEA:69504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine + O2 = H2O2 + N-acetyl-D-glucosamino-1,5-lactone
GO:0004501	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)
GO:0004501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone 20-hydroxylase activity
GO:0004501	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ecdysone C-20 hydroxylase activity
GO:0004501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone 20-monooxygenase activity
GO:0004501	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ecdysone modification
RHEA:52664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain (3S)-3-hydroxyacyl-CoA = a short-chain (2E)-enoyl-CoA + H2O
RHEA:52664	skos:prefLabel	"short-chain-enoyl-CoA hydratase"
RHEA:52664	skos:altLabel	"3-hydroxybutyryl-CoA dehydratase"
RHEA:52664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"short-chain-enoyl-CoA hydratase"
RHEA:52664	skos:altLabel	"crotonase"
REACT:R-GGA-191072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Cx43 (Gallus gallus)
REACT:R-SSC-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Sus scrofa)
RHEA:14414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,3-diol + O2 => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)
GO:0102536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sakuranetin 6-hydroxylase activity
REACT:R-CFA-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Canis familiaris)
REACT:R-RNO-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Rattus norvegicus)
REACT:R-SSC-1855172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Sus scrofa)
RHEA:58095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)
RHEA:51874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + osthenol => dimethylallyl diphosphate + umbelliferone
RHEA:61276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-ornithine + O2 = 5-amino-2-oxopentanoate + H2O2 + NH4(+)
RHEA:52113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
REACT:R-MMU-5635855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Mus musculus)
RHEA:52131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)
RHEA:24949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methylglutarate + malonyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + malonate
REACT:R-DRE-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Danio rerio)
RHEA:69803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + benzoate + H(+) = benzoyl-AMP + diphosphate
REACT:R-DME-1855153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Drosophila melanogaster)
REACT:R-GGA-1370505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR is phosphorylated at Ser-349 (Gallus gallus)
REACT:R-DRE-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Danio rerio)
REACT:R-RNO-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Rattus norvegicus)
REACT:R-HSA-9623018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1 binds AGRP gene promoter (Homo sapiens)
REACT:R-MMU-1112604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STATs are released (Mus musculus)
REACT:R-XTR-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Xenopus tropicalis)
RHEA:71586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(in) + Na(+)(in) <=> L-histidine(out) + Na(+)(out)
REACT:R-HSA-202245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TBSMs in LAT (Homo sapiens)
REACT:R-SSC-5218645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 binds p-Y397-PTK2 (Sus scrofa)
RHEA:52308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH
RHEA:66419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate
REACT:R-XTR-8983374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Xenopus tropicalis)
REACT:R-DRE-6804596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1:CYCS binds APIP (Danio rerio)
RHEA:22342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzaldehyde + H(+) + NADPH => 3-hydroxybenzyl alcohol + NADP(+)
REACT:R-HSA-4608866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VANGL2 is required for asymmetric membrane localization of FZD3 (Homo sapiens)
REACT:R-HSA-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
REACT:R-CFA-5696146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC2 deaminates TYR (Canis familiaris)
REACT:R-SPO-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Schizosaccharomyces pombe)
RHEA:19973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spermine synthase"
RHEA:19973	skos:prefLabel	"spermine synthase"
RHEA:19973	skos:altLabel	"spermidine aminopropyltransferase"
RHEA:19973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + spermine
REACT:R-MMU-164832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase synthesizes ATP (Mus musculus)
RHEA:36716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + tetracosenoyl-CoA => an N-tetracosenoylsphinganine + CoA + H(+)
REACT:R-DRE-451895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RG binds JAK3 (Danio rerio)
REACT:R-CFA-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Canis familiaris)
RHEA:42045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) => GDP + globoside Globo-H (d18:1(4E)) + H(+)
REACT:R-XTR-3928612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KALRN exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
RHEA:15468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + sphinganine <=> ADP + H(+) + sphinganine 1-phosphate
REACT:R-MMU-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Mus musculus)
REACT:R-SCE-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Saccharomyces cerevisiae)
RHEA:34021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + glycerol + H(+) => a 1-acylglycerol + H2O
REACT:R-DME-975142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Drosophila melanogaster)
REACT:R-GGA-9668419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Gallus gallus)
REACT:R-HSA-3134804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING ubiquitination by TRIM32 or TRIM56 (Homo sapiens)
RHEA:27662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2
REACT:R-BTA-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Bos taurus)
REACT:R-RNO-2454118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cRAL binds to opsin to form 11c-retinyl:RHO (Rattus norvegicus)
REACT:R-XTR-5654423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)
RHEA:58601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine
REACT:R-CFA-5218815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds NCK (Canis familiaris)
RHEA:27384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-2-phosphoglycerate + phosphate
RHEA:35753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-kanosamine 6-phosphate + H(+) => ATP + kanosamine
REACT:R-XTR-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Xenopus tropicalis)
REACT:R-XTR-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)
RHEA:12333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Fe(3+)(out) + H2O => ADP + Fe(3+)(in) + H(+) + phosphate
REACT:R-SSC-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Sus scrofa)
REACT:R-XTR-8952044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Xenopus tropicalis)
RHEA:64669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate
RHEA:65205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA + H2O => (R)-3-hydroxybutanoate + CoA + H(+)
REACT:R-MMU-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Mus musculus)
RHEA:61252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-valine + O2 = 3-methyl-2-oxobutanoate + H2O2 + NH4(+)
RHEA:34643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"squalene methyltransferase"
RHEA:34643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + squalene = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:34643	skos:prefLabel	"squalene methyltransferase"
REACT:R-RNO-2022398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Rattus norvegicus)
REACT:R-HSA-879762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DBP (Homo sapiens)
RHEA:19242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0033982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SgaH
GO:0033982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity
GO:0033982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity
GO:0033982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SgbH
GO:0033982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KGPDC
GO:0033982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-keto-L-gulonate 6-phosphate decarboxylase activity
GO:0033982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UlaD
GO:0033982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
REACT:R-HSA-8875817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates STAT3 (Homo sapiens)
RHEA:34902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + S-adenosyl-L-methionine <=> malonyl-CoA methyl ester + S-adenosyl-L-homocysteine
RHEA:43555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate
REACT:R-RNO-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Rattus norvegicus)
REACT:R-RNO-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Rattus norvegicus)
RHEA:43839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADPH + O2 <=> 26-hydroxycholesterol + H2O + NADP(+)
RHEA:67033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-8963915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D binds VDR (Danio rerio)
REACT:R-SSC-390641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA1A,B,D bind ADR,NAd (Sus scrofa)
RHEA:51316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + glycine = H2O + N-(9Z-octadecenoyl)glycine
RHEA:59476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + 2 ATP + benzoate + L-phenylalanine = 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol
RHEA:45717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N,N-trimethylglycyl-CoA => CoA + glycine betaine + H(+)
REACT:R-CFA-9647987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTB inhibitors bind FNTA:FNTB (Canis familiaris)
REACT:R-HSA-6801762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A oligomerize to form a pore complex (Homo sapiens)
REACT:R-RNO-432164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Rattus norvegicus)
RHEA:68210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA => (7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol
REACT:R-HSA-3662335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
RHEA:40523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + succinate = a quinol + fumarate
REACT:R-DME-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Drosophila melanogaster)
REACT:R-HSA-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)
REACT:R-SPO-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Schizosaccharomyces pombe)
RHEA:40531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0005003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ephrin receptor activity
GO:0005003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Eph receptor activity
REACT:R-HSA-8874705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Homo sapiens)
REACT:R-CFA-8871366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Canis familiaris)
RHEA:48976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + pyocyanin
RHEA:31571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 = CO2 + H2O + NADP(+) + naphthalene-1,2-diol
RHEA:66411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate
REACT:R-DRE-8982162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Danio rerio)
RHEA:27634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH
REACT:R-DRE-9033961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Danio rerio)
REACT:R-DRE-5658231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs stimulate RAS GTPase activity (Danio rerio)
REACT:R-CFA-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Canis familiaris)
REACT:R-GGA-8987084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Gallus gallus)
REACT:R-HSA-8876616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND6A,B exchange GTP for GDP on RAB14 (Homo sapiens)
REACT:R-HSA-3132759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds RCbl (Homo sapiens)
REACT:R-CFA-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Canis familiaris)
RHEA:11195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (S)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)
RHEA:19124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted glutathione(in) + ATP + H2O <=> ADP + an S-substituted glutathione(out) + H(+) + phosphate
GO:0031386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein tag
GO:0031386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	covalent modifier
GO:0031386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ubiquitin
GO:0031386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein tagging activity
GO:0031386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein modifier
RHEA:54235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycerol + CDP-choline <=> 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-MMU-426209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG activation of TRPC channels (Mus musculus)
REACT:R-CFA-749454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
REACT:R-CEL-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)
REACT:R-GGA-158766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Gallus gallus)
REACT:R-SCE-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Saccharomyces cerevisiae)
REACT:R-DME-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Drosophila melanogaster)
RHEA:46232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DDI-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Dictyostelium discoideum)
RHEA:23533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholate + CoA => AMP + choloyl-CoA + diphosphate
REACT:R-MMU-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Mus musculus)
RHEA:27276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+)
RHEA:61559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:64491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA <=> 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA
REACT:R-RNO-8932955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:48421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) => CMP + ganglioside GM1 (d18:1(4E)) + H(+)
RHEA:56029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
RHEA:59032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-DME-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Drosophila melanogaster)
RHEA:34798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> alpha-D-ribose 1,5-bisphosphate + H(+)
RHEA:43933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + NAD(+) => androst-5-ene-3,17-dione + H(+) + NADH
REACT:R-HSA-2168038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XV restin release (Homo sapiens)
REACT:R-GGA-9005980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 binds IL21R:JAK1 (Gallus gallus)
REACT:R-GGA-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Gallus gallus)
RHEA:50000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"butane monooxygenase (soluble)"
RHEA:50000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butane + H(+) + NADH + O2 = butan-1-ol + H2O + NAD(+)
RHEA:50000	skos:prefLabel	"butane monooxygenase (soluble)"
RHEA:15023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-feruloyl-D-quinate + CoA => (E)-feruloyl-CoA + L-quinate
REACT:R-HSA-9698928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Late (L) Gene Expression (Homo sapiens)
REACT:R-HSA-180597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex (Homo sapiens)
REACT:R-DRE-6798044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTG2 binds CCR4-NOT complex (Danio rerio)
REACT:R-SSC-8849463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates SFPQ (Sus scrofa)
REACT:R-HSA-1791144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of EXTL3 (Homo sapiens)
RHEA:60047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP
RHEA:49119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NADP(+)
REACT:R-DRE-433104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACT co-transports trivalent citrate and a sodium ion (Danio rerio)
RHEA:45763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-daunosamine + epsilon-rhodomycinone <=> dTDP + H(+) + rhodomycin D
REACT:R-RNO-8858428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FCAMR binds IgA (Rattus norvegicus)
RHEA:14402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlordecone alcohol + NADP(+) => chlordecone + H(+) + NADPH
RHEA:33821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate
REACT:R-DRE-389919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds pBTLA (Danio rerio)
RHEA:19895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP
REACT:R-XTR-6806831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5Rs reduce MetHb to HbA (Xenopus tropicalis)
RHEA:45479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-BTA-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Bos taurus)
RHEA:47649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 5-phosphate + H2O => phosphate + ribitol
RHEA:69024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-hydroxy-L-aspartate + NADPH + O2 = H2O + N,N-dihydroxy-L-aspartate + NADP(+)
REACT:R-BTA-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Bos taurus)
REACT:R-DRE-432143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM-1 binds PP2A (Danio rerio)
GO:0089710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endocytic targeting sequence binding
REACT:R-MMU-8959719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPK phosphorylates Sedo to Sedo7P (Mus musculus)
RHEA:30042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NADP(+)
RHEA:41106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)
REACT:R-DME-2064421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds ZO-2 (TJP2) (Drosophila melanogaster)
RHEA:58403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptan-1-ol + NADP(+) <=> H(+) + heptanal + NADPH
REACT:R-DME-390133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YKI transports from the cytosol to the nucleus (Drosophila melanogaster)
REACT:R-MMU-1168643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCP ubiquitinylates IkB (Mus musculus)
REACT:R-MMU-374664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of Ezrin (Mus musculus)
RHEA:16511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formate => H(+) + oxalate
REACT:R-HSA-5218839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
REACT:R-RNO-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Rattus norvegicus)
REACT:R-GGA-217152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a multi-protein complex, cohesin (Gallus gallus)
REACT:R-BTA-163625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon binds to Glucagon receptor (Bos taurus)
REACT:R-BTA-9648983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Bos taurus)
REACT:R-CFA-70355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALK1 phosphorylates Gal to Gal1P (Canis familiaris)
GO:0102537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone-phosphate phosphatase activity
RHEA:67482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + kainate + succinate => 2-oxoglutarate + O2 + prekainate
REACT:R-CFA-5638007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 activates the GTPase activity of ARL3 (Canis familiaris)
REACT:R-CEL-201475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with R-Smad1/5/8 for type I receptor (Caenorhabditis elegans)
RHEA:72417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Li(+)(out) + Na(+)(in) => Li(+)(in) + Na(+)(out)
RHEA:46164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H(+) + NADPH = a quinol + NADP(+)
RHEA:65097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + hexadecanoyl-CoA => a 1-hexadecanoyl-2-acylglycerol + CoA
REACT:R-HSA-9630043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective NTHL1 truncation mutants do not bind thymine glycol (Tg) (Homo sapiens)
RHEA:38411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)
RHEA:20251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine => L-alanine
EC:3.4.17.1	skos:prefLabel	"carboxypeptidase A"
EC:3.4.17.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxypeptidase A"
EC:3.4.17.1	skos:altLabel	"carboxypolypeptidase"
REACT:R-GGA-420131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PACAP receptor binds PACAP (Gallus gallus)
RHEA:61047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:70288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3,4,6-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)
RHEA:15004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-sorbose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH
RHEA:70973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+) => D-dopa + H2O + O2
REACT:R-DRE-9734535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Danio rerio)
REACT:R-HSA-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Homo sapiens)
REACT:R-BTA-70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Bos taurus)
REACT:R-DDI-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Dictyostelium discoideum)
REACT:R-HSA-451942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Within the IL-2R complex JAK3 phosphorylates JAK1 (Homo sapiens)
RHEA:58257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] => ADP-D-ribose + L-seryl-[protein]
RHEA:41213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+) => (indol-3-yl)acetate + H(+) + NADH + O2
RHEA:16572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[collagen] + O2 <=> (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate
REACT:R-MMU-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Mus musculus)
REACT:R-DDI-8953917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)
GO:0018025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity
GO:0018025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calmodulin-lysine N-methyltransferase activity
GO:0018025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity
GO:0018025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity
REACT:R-CFA-3076905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular BTD hydrolyses BCTN (Canis familiaris)
REACT:R-DME-9699579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of FLT3  (Drosophila melanogaster)
REACT:R-SSC-6799179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Sus scrofa)
RHEA:58006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside F2 + UDP-alpha-D-glucose
REACT:R-XTR-114548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Xenopus tropicalis)
REACT:R-GGA-2453833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)
RHEA:35890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-CEL-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Caenorhabditis elegans)
RHEA:65634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-tetracosanoyl-sphingoid base + CoA + H(+) => a sphingoid base + tetracosanoyl-CoA
REACT:R-DRE-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Danio rerio)
REACT:R-SSC-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Sus scrofa)
RHEA:40070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)
REACT:R-RNO-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Rattus norvegicus)
REACT:R-HSA-9611158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of HCMV Envelope with Plasma Membrane (Homo sapiens)
REACT:R-HSA-109278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Homo sapiens)
REACT:R-SSC-177107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion and activation of the latent large complex of TGF-beta-1 (Sus scrofa)
REACT:R-CEL-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Caenorhabditis elegans)
GO:0043199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate binding
REACT:R-MMU-166795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Classical C3 convertase (C4b:C2a complex) (Mus musculus)
GO:0004000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine aminohydrolase activity
GO:0004000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine deaminase reaction
GO:0004000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine deaminase activity
GO:0102701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = diphosphate + tricyclene
GO:0102701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tricyclene synthase activity
GO:0102701	skos:prefLabel	"tricyclene synthase"
GO:0102701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tricyclene synthase"
REACT:R-PFA-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
RHEA:47213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:63724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP
REACT:R-SPO-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Schizosaccharomyces pombe)
GO:0047935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose 1-dehydrogenase (NADP+) activity
GO:0047935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity
GO:0047935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose:NADP+ 1-oxidoreductase activity
GO:0047935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent glucose dehydrogenase activity
GO:0047935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-linked aldohexose dehydrogenase activity
RHEA:52525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethylfurfural + 2 H2O + 3 O2 => 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2
RHEA:66764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + folate(in) + H2O = ADP + folate(out) + H(+) + phosphate
RHEA:34745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-methyltetradecanal + phosphoethanolamine => 15-methylhexadecasphinganine 1-phosphate
REACT:R-DDI-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Dictyostelium discoideum)
RHEA:52218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose => [(1''->2')-ADP-alpha-D-ribose](n) + H2O
REACT:R-MMU-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Mus musculus)
RHEA:21635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 catechol + O2 <=> 2 1,2-benzoquinone + 2 H2O
REACT:R-DME-6811508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2-bound EP300 acetylates TP53 (Drosophila melanogaster)
REACT:R-SSC-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Sus scrofa)
RHEA:21191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + deamido-NAD(+) + NH4(+) <=> AMP + diphosphate + H(+) + NAD(+)
RHEA:33499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prephenate decarboxylase"
RHEA:33499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2
RHEA:33499	skos:prefLabel	"prephenate decarboxylase"
RHEA:33499	skos:altLabel	"non-aromatizing prephenate decarboxylase"
REACT:R-CFA-873927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of STAT1 dimer from active receptor unit (Canis familiaris)
GO:0050485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a disulfide as acceptor"
GO:0050485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor
GO:0050485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor
GO:0050485	skos:prefLabel	"With a disulfide as acceptor"
RHEA:45759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine
GO:0015298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:cation antiporter activity
RHEA:57843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3-bisphosphate + H2O <=> 1D-myo-inositol 1-phosphate + phosphate
REACT:R-MMU-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Mus musculus)
RHEA:66486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP => 16alpha-hydroxygypsogenate + UDP-alpha-D-glucose
RHEA:44948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)
RHEA:11946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O
RHEA:39690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-(11Z)-octadecenoyl-CoA <=> (2E,11Z)-octadecadienoyl-CoA + H2O
RHEA:40191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH
RHEA:67628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-amino-2'-deoxyadenylo-succinate synthase"
RHEA:67628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dGMP + L-aspartate = (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate
RHEA:67628	skos:prefLabel	"2-amino-2'-deoxyadenylo-succinate synthase"
GO:0047435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity
GO:0047435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)
GO:0047435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate decarboxylase activity
GO:0047435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-5-guanidinopentanoate carboxy-lyase activity
GO:0047435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoarginine decarboxylase activity
GO:0047435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-5-guanidinopentanoate decarboxylase activity
RHEA:41197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-MMU-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)
REACT:R-RNO-176116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of Chk1 (Rattus norvegicus)
RHEA:39547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA = (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O
REACT:R-XTR-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Xenopus tropicalis)
REACT:R-SSC-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Sus scrofa)
RHEA:12984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + S-sulfanylglutathione <=> glutathione + 2 H(+) + sulfite
REACT:R-HSA-6783670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1 binds CLCF1 (Homo sapiens)
REACT:R-BTA-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)
RHEA:12897	skos:altLabel	"ABA 8'-hydroxylase"
RHEA:12897	skos:altLabel	"CYP707A1"
RHEA:12897	skos:altLabel	"(+)-ABA 8'-hydroxylase"
RHEA:12897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-abscisic acid 8'-hydroxylase"
RHEA:12897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:12897	skos:prefLabel	"(+)-abscisic acid 8'-hydroxylase"
REACT:R-MMU-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Mus musculus)
REACT:R-GGA-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Gallus gallus)
REACT:R-CFA-193393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Canis familiaris)
REACT:R-RNO-1112604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STATs are released (Rattus norvegicus)
REACT:R-GGA-8852552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1R autophosphorylates (Gallus gallus)
RHEA:47501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
RHEA:17298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA
RHEA:45012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + octadecanoate
RHEA:42025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) => 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH
REACT:R-HSA-1369028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid efflux (Homo sapiens)
RHEA:47812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)
RHEA:27512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydro coenzyme F420-0 + GMP + H(+) => 7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine
RHEA:40314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + O2 <=> (2E)-hexenoyl-CoA + H2O2
REACT:R-CFA-1433488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHP2 by SFKs (Canis familiaris)
REACT:R-HSA-2172405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XXIII ectodomain shedding (Homo sapiens)
REACT:R-SSC-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Sus scrofa)
RHEA:24594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ethanolamine + diphosphate => CTP + H(+) + phosphoethanolamine
RHEA:30779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + FAD + H(+) = 2-dehydro-D-gluconate + FADH2
RHEA:37856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA => 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:10635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NAD(+) <=> D-mannuronate + H(+) + NADH
REACT:R-BTA-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Bos taurus)
REACT:R-HSA-202713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD84 homodimerises (Homo sapiens)
RHEA:25678	skos:altLabel	"O-phosphoseryl-tRNA ligase"
RHEA:25678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)
RHEA:25678	skos:altLabel	"SepRS"
RHEA:25678	skos:prefLabel	"O-phosphoserine--tRNA ligase"
RHEA:25678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-phosphoserine--tRNA ligase"
REACT:R-CEL-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Caenorhabditis elegans)
RHEA:49299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + L-sorbose 1-phosphate(in)
REACT:R-DRE-5228523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates MDM2 with SUMO1 (Danio rerio)
REACT:R-DME-201629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Tau (Drosophila melanogaster)
REACT:R-SSC-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Sus scrofa)
REACT:R-SSC-1482679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2G2A (Sus scrofa)
RHEA:20858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + sphing-4-enine => an N-acylsphing-4-enine + H2O
REACT:R-MMU-174967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT2 acetylation (Mus musculus)
REACT:R-BTA-8943040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF polyubiquitinates monoubiquitinated PCNA (Bos taurus)
RHEA:51267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADH => (6S)-NADHX
REACT:R-MMU-1678716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(1) (Mus musculus)
GO:0047699	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidized PVA hydrolase activity
GO:0047699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	b-diketone hydrolase activity
GO:0047699	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nonane-4,6-dione acylhydrolase activity
GO:0047699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-diketone hydrolase activity
REACT:R-MMU-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)
RHEA:33492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexacosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine
RHEA:53374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NAD(+)
RHEA:19153	skos:prefLabel	"flavone apiosyltransferase"
RHEA:19153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavone apiosyltransferase"
RHEA:19153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose = 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP
GO:0008336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-butyrobetaine,2-oxoglutarate dioxygenase activity
GO:0008336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
GO:0008336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-butyrobetaine hydroxylase activity
GO:0008336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyrobetaine hydroxylase activity
GO:0008336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-butyrobetaine dioxygenase activity
GO:0008336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-BBH activity
GO:0008336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-butyrobetaine hydroxylase activity
GO:0008336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	g-butyrobetaine dioxygenase activity
REACT:R-BTA-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Bos taurus)
REACT:R-DRE-192042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Danio rerio)
REACT:R-RNO-1011600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rabenosyn-5 connects  Rab5 to VPS-45 (Rattus norvegicus)
REACT:R-DDI-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Dictyostelium discoideum)
REACT:R-DME-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Drosophila melanogaster)
RHEA:46888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2
RHEA:46888	skos:prefLabel	"3-deoxy-alpha-D-manno-octulosonate 8-oxidase"
RHEA:46888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-alpha-D-manno-octulosonate 8-oxidase"
RHEA:42805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + A => 7,8-dihydromethanopterin + AH2
REACT:R-XTR-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Xenopus tropicalis)
REACT:R-RNO-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Rattus norvegicus)
REACT:R-MMU-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Mus musculus)
RHEA:36519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexacosanoyl-CoA + malonyl-CoA = 3-oxooctacosanyol-CoA + CO2 + CoA
RHEA:44534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine
EC:7.6.2.13	skos:altLabel	"LsrACDB (gene names)"
EC:7.6.2.13	skos:altLabel	"autoinducer-2 transporting ATPase"
EC:7.6.2.13	skos:altLabel	"autoinducer-2 ABC transporter"
EC:7.6.2.13	skos:prefLabel	"ABC-type autoinducer-2 transporter"
EC:7.6.2.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type autoinducer-2 transporter"
REACT:R-DME-111915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK4 autophosphorylates (Drosophila melanogaster)
REACT:R-HSA-2574845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA binds centrosome-associated AURKA (Homo sapiens)
REACT:R-DME-9755306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub UBXN7 is degraded by the 26S proteasome (Drosophila melanogaster)
REACT:R-XTR-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Xenopus tropicalis)
REACT:R-MMU-163625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon binds to Glucagon receptor (Mus musculus)
REACT:R-XTR-5626982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF binds GNB2L1 (Xenopus tropicalis)
REACT:R-SSC-374663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interaction with Ezrin (Sus scrofa)
REACT:R-MMU-391151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47:SKAP2 binds FYB (Mus musculus)
RHEA:42401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + lactose 6-phosphate(in)
REACT:R-XTR-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Xenopus tropicalis)
RHEA:38986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)
RHEA:30613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-neurosporene => A + all-trans-zeta-carotene
REACT:R-GGA-5654600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
REACT:R-PFA-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
REACT:R-CFA-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Canis familiaris)
RHEA:71697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + L-alanyl-L-aspartate(in) => 2 H(+)(out) + L-alanyl-L-aspartate(out)
REACT:R-SSC-77312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Sus scrofa)
RHEA:64083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]
REACT:R-CFA-2022860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Canis familiaris)
REACT:R-XTR-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Xenopus tropicalis)
REACT:R-RNO-6797627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPG hydrolyses L-Asn to L-Asp (Rattus norvegicus)
REACT:R-GGA-5688786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds RAD23 (Gallus gallus)
REACT:R-HSA-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Homo sapiens)
RHEA:36924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA
REACT:R-GGA-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Gallus gallus)
REACT:R-HSA-1475026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (cytosol) (Homo sapiens)
REACT:R-BTA-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Bos taurus)
RHEA:21570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose => beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O
REACT:R-CFA-5218830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates PTK2-beta (Canis familiaris)
REACT:R-CFA-173725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C9 binds C5b:C6:C7:C8 (Canis familiaris)
GO:0042901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinan transmembrane transporter activity
RHEA:19206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + 2 H2O => diphosphate + dUMP + NH4(+)
RHEA:55258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:65291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine
REACT:R-SSC-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Sus scrofa)
REACT:R-SPO-380927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK phosphorylates TSC1:TSC2 (Schizosaccharomyces pombe)
RHEA:38512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)
REACT:R-RNO-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)
REACT:R-BTA-450474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates BRF1 (Bos taurus)
REACT:R-PFA-9796368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 binds STUB1 (Plasmodium falciparum)
REACT:R-RNO-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Rattus norvegicus)
REACT:R-CFA-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Canis familiaris)
REACT:R-RNO-2730858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of BTK/ITK (Rattus norvegicus)
RHEA:23983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclomaltodextrin + H2O <=> linear maltodextrin
REACT:R-SSC-8850529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGS proteins bind GNB5 and CCT/TRiC (Sus scrofa)
REACT:R-HSA-199579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR2DL4 interacting with HLA-G (Homo sapiens)
REACT:R-CFA-391152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds PTK2B (Canis familiaris)
REACT:R-DRE-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Danio rerio)
REACT:R-HSA-109857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 binds MAPK3 (Homo sapiens)
RHEA:12459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + D-ribitol 5-phosphate + H(+) <=> CDP-L-ribitol + diphosphate
REACT:R-HSA-388832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds CD28 (Homo sapiens)
RHEA:19728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + UDP-alpha-D-galacturonate <=> CO2 + UDP-beta-L-arabinopyranose
RHEA:16430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
REACT:R-MMU-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Mus musculus)
RHEA:67266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine => (2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine
RHEA:10212	skos:altLabel	"delta-aminovalerate aminotransferase"
RHEA:10212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate
RHEA:10212	skos:altLabel	"delta-aminovalerate transaminase"
RHEA:10212	skos:prefLabel	"5-aminovalerate transaminase"
RHEA:10212	skos:altLabel	"5-aminovalerate aminotransferase"
RHEA:10212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-aminovalerate transaminase"
RHEA:28313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	eukaryotic elongation factor 2 kinase activity
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CaM kinase III activity
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	elongation factor-2 kinase activity
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ca/CaM-kinase III activity
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	elongation factor 2 kinase activity
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	EF2K
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:elongation factor 2 phosphotransferase activity
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	calmodulin-dependent protein kinase III activity
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eEF-2 kinase activity
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	eEF2K
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	eEF2 kinase activity
GO:0004686	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK19
REACT:R-GGA-390595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Troponin-C (Gallus gallus)
GO:0038024	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	receptor activity
GO:0038024	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	receptor activity involved in receptor-mediated endocytosis
GO:0038024	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transport receptor activity
GO:0038024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cargo receptor activity
GO:0038024	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endocytic receptor activity
REACT:R-MMU-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Mus musculus)
RHEA:62917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine => an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine
RHEA:17307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + L-citrulline => H2O + N(omega),N(omega)-dimethyl-L-arginine
REACT:R-CFA-6813659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE, CTSG or PRTN3 binds bacteria (Canis familiaris)
REACT:R-CEL-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
REACT:R-GGA-9706345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Gallus gallus)
RHEA:45969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADH + O2 => 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)
REACT:R-RNO-1592387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin binds elastic fibres (Rattus norvegicus)
REACT:R-DME-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)
REACT:R-XTR-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)
GO:0050542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	icosanoid binding
GO:0050542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoid binding
REACT:R-HSA-8851979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL9 binds immune cell surfaces (Homo sapiens)
REACT:R-SSC-202233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Lck by Csk (Sus scrofa)
REACT:R-XTR-3134954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX9 binds DNA (Xenopus tropicalis)
REACT:R-BTA-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Bos taurus)
REACT:R-HSA-373791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Homo sapiens)
RHEA:22535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenedioyl-CoA + H2O <=> (3S)-hydroxyoctanedioyl-CoA
RHEA:34486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> 4-hydroxybenzalacetone + 2 CO2 + 2 CoA
REACT:R-CFA-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Canis familiaris)
REACT:R-SSC-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Sus scrofa)
RHEA:34264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + fumigaclavine A => diphosphate + fumigaclavine C
REACT:R-RNO-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Rattus norvegicus)
REACT:R-BTA-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Bos taurus)
RHEA:27307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-proline => 1-pyrroline-2-carboxylate + AH2
REACT:R-CEL-8871266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD3 (Caenorhabditis elegans)
GO:0000248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SC5D desaturates LTHSOL to 7-dehydroCHOL (Homo sapiens)
GO:0000248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Homo sapiens)
GO:0000248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol-C5-desaturase activity
GO:0000248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-5 sterol desaturase activity
REACT:R-RNO-381262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPARG:RXRA heterodimer (ARF6 complex) (Rattus norvegicus)
RHEA:23068	skos:altLabel	"deoxyerythronolide B synthase"
RHEA:23068	skos:altLabel	"6-deoxyerythronolide B synthase"
RHEA:23068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-deoxyerythronolide-B synthase"
RHEA:23068	skos:altLabel	"erythronolide synthase"
RHEA:23068	skos:altLabel	"erythronolide-condensing enzyme"
RHEA:23068	skos:prefLabel	"6-deoxyerythronolide-B synthase"
RHEA:23068	skos:altLabel	"DEBS"
RHEA:23068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA = 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)
GO:1901702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salt transmembrane transporter activity
REACT:R-SSC-8855237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Sus scrofa)
RHEA:68070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-983696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Immunoglobulin of the BCR binds antigen (Danio rerio)
RHEA:67285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione => (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione
RHEA:71273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + thiamine(in) => H(+)(in) + thiamine(out)
RHEA:38283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	itaconate + succinyl-CoA = itaconyl-CoA + succinate
REACT:R-CFA-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Canis familiaris)
RHEA:38724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol
GO:0015229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbic acid transmembrane transporter activity
GO:0015229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate transporter activity
GO:0015229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin C transporter activity
GO:0015229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-XTR-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Xenopus tropicalis)
RHEA:17697	skos:altLabel	"thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase"
RHEA:17697	skos:altLabel	"thiaminase"
RHEA:17697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine
RHEA:17697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiamine pyridinylase"
RHEA:17697	skos:altLabel	"pyrimidine transferase"
RHEA:17697	skos:altLabel	"thiamine pyridinolase"
RHEA:17697	skos:prefLabel	"thiamine pyridinylase"
RHEA:17697	skos:altLabel	"thiamine hydrolase"
RHEA:17697	skos:altLabel	"thiaminase I"
RHEA:55063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-8944219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVI (Rattus norvegicus)
RHEA:43850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + arsenite + H2O => [thioredoxin]-dithiol + arsenate + H(+)
RHEA:13371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + isoprene => dimethylallyl diphosphate
REACT:R-RNO-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Rattus norvegicus)
REACT:R-MMU-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Mus musculus)
REACT:R-SCE-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Saccharomyces cerevisiae)
RHEA:52628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-fatty-acyl-L-alpha-amino acid + H2O = a fatty acid + an L-alpha-amino acid
RHEA:31281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
GO:0043398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLH domain binding
RHEA:69118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + glycine => glyoxylate + L-tyrosine
RHEA:69326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanylbutyl isothionate + H(+) + sulfate => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate
RHEA:33741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanal + NAD(+) => 2 H(+) + hexadecanoate + NADH
REACT:R-CEL-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Caenorhabditis elegans)
REACT:R-CFA-5634228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 is cleaved by caspases (Canis familiaris)
REACT:R-SSC-77319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Sus scrofa)
REACT:R-DRE-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Danio rerio)
REACT:R-XTR-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Xenopus tropicalis)
RHEA:24774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide b + H(+) + NADPH => 7(1)-hydroxychlorophyllide a + NADP(+)
RHEA:44968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA + H(+) + NADPH = NADP(+) + tetradecanoyl-CoA
RHEA:26560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA
REACT:R-XTR-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Xenopus tropicalis)
RHEA:44955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H(+) + NADPH <=> NADP(+) + octanoyl-CoA
RHEA:30595	skos:altLabel	"4 HPA 3-hydroxylase"
RHEA:30595	skos:altLabel	"4-hydroxyphenylacetic acid-3-hydroxylase"
RHEA:30595	skos:prefLabel	"4-hydroxyphenylacetate 3-monooxygenase"
RHEA:30595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylacetate 3-monooxygenase"
RHEA:30595	skos:altLabel	"p-hydroxyphenylacetate 3-hydroxylase"
RHEA:30595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O
REACT:R-DRE-1363328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Danio rerio)
REACT:R-MMU-191790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading and methylation of Sm proteins onto SMN Complexes (Mus musculus)
RHEA:31306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a reduced flavin + NAD(+) <=> an oxidized flavin + 2 H(+) + NADH
GO:0016307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol phosphate kinase activity
GO:0016307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol monophosphate kinase activity
REACT:R-CEL-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Caenorhabditis elegans)
RHEA:31764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid
RHEA:14643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biuret + CO2 => cyanurate + H2O
RHEA:33226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA
RHEA:21167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylic ester + H2O <=> a carboxylate + an alcohol + H(+)
REACT:R-XTR-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Xenopus tropicalis)
RHEA:31561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-galactono-1,4-lactone + NADH => L-galactose + NAD(+)
REACT:R-RNO-1250220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of ERBB4 (Rattus norvegicus)
REACT:R-DME-5340251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Drosophila melanogaster)
REACT:R-CEL-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Caenorhabditis elegans)
RHEA:68965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanoate + O2 => 2-oxooctadecanoate + H2O2
RHEA:69365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-diazo-5-oxo-L-norleucine + acetyl-CoA => CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine
REACT:R-RNO-6809264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Rattus norvegicus)
RHEA:25783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine <=> 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate
REACT:R-SPO-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Schizosaccharomyces pombe)
RHEA:48686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-L-glutamate + L-lysine => [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O
GO:0008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	para-hydroxybenzoate-polyprenyl diphosphate transferase activity
GO:0008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	para-hydroxybenzoate transferase activity
GO:0008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-HB polyprenyltransferase activity
GO:0008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	para-hydroxybenzoate:polyprenyltransferase activity
GO:0008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB polyprenyl diphosphate transferase activity
GO:0008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate octaprenyltransferase activity
GO:0102311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxygeraniol dehydrogenase activity
EC:3.4.23.4	skos:altLabel	"rennin"
EC:3.4.23.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chymosin"
EC:3.4.23.4	skos:prefLabel	"chymosin"
REACT:R-DDI-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Dictyostelium discoideum)
RHEA:29413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate(out) + H(+)(out) => glycolate(in) + H(+)(in)
RHEA:13252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH
RHEA:21395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + H2O + NAD(+) <=> 2-phenylacetate + 2 H(+) + NADH
RHEA:59943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyloctadecanoyl-CoA + H2O <=> 2-methyloctadecanoate + CoA + H(+)
RHEA:34380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP
RHEA:66153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + noradrenaline => CoA + H(+) + N-acetylnoradrenaline
REACT:R-BTA-4570554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO1 (Bos taurus)
REACT:R-CFA-917933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Canis familiaris)
RHEA:69626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-D-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-D-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP
REACT:R-BTA-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Bos taurus)
REACT:R-DRE-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Danio rerio)
REACT:R-DDI-936563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of DDX58 (Dictyostelium discoideum)
REACT:R-DME-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Drosophila melanogaster)
RHEA:49799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-glycine + H2O <=> a fatty acid + glycine
REACT:R-SSC-9712210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Sus scrofa)
GO:0101013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanically-modulated voltage-gated sodium channel activity
GO:0101013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanosensitive voltage-gated sodium channel activity
REACT:R-HSA-5661240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCXR tetramer reduces L-xylulose to xylitol (Homo sapiens)
REACT:R-SCE-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Saccharomyces cerevisiae)
RHEA:30794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + pyruvate <=> dGDP + H(+) + phosphoenolpyruvate
REACT:R-SSC-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Sus scrofa)
GO:0019959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-8 binding
GO:0019959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-8 binding
RHEA:68463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a phenolic steroid <=> a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:44125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + tetradecan-1-ol => CoA + tetradecanyl hexadecanoate
REACT:R-DRE-198870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Danio rerio)
RHEA:57150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine
REACT:R-XTR-2018682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Xenopus tropicalis)
RHEA:20240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)
REACT:R-HSA-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Homo sapiens)
RHEA:51254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2
RHEA:40614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trihexanoylglycerol <=> 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate
RHEA:64643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose <=> lactose + N-acetylneuraminate
REACT:R-RNO-193072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)
RHEA:33367	skos:prefLabel	"protein-N(pi)-phosphohistidine--D-glucose phosphotransferase"
RHEA:33367	skos:altLabel	"D-glucose PTS permease"
RHEA:33367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucose 6-phosphate(in) + L-histidyl-[protein]
RHEA:33367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--D-glucose phosphotransferase"
GO:0102465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zeaxanthin 2,2'-beta-hydroxylase activity
REACT:R-SSC-6801766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Sus scrofa)
RHEA:57387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA <=> (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA
GO:0047409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity
GO:0047409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkenylglycerophosphoethanolamine hydrolase activity
RHEA:16074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dialkylglycine + H(+) + pyruvate => CO2 + dialkyl ketone + L-alanine
RHEA:15896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-sirohydrochlorin + 2 H(+) <=> Co(2+) + sirohydrochlorin
REACT:R-DDI-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)
RHEA:46055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end uridylyl-uridine-RNA <=> a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine
REACT:R-BTA-266299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds membrane-associated free cholesterol and phospholipids (Bos taurus)
REACT:R-SSC-9649963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC3 channel blockers bind ASIC3 trimer (Sus scrofa)
REACT:R-SPO-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Schizosaccharomyces pombe)
GO:0097682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity
REACT:R-GGA-1227893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex (Gallus gallus)
REACT:R-CFA-382054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binds to extracellular matrix proteins (Canis familiaris)
RHEA:52828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 = (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)
RHEA:71467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P = L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)
RHEA:37365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2
REACT:R-DME-209185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane (Drosophila melanogaster)
RHEA:68122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + CoA => a 1,2-diacylglycerol + a fatty acyl-CoA
REACT:R-DME-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)
RHEA:22269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin => ADP + H(+) + streptomycin 6-phosphate
REACT:R-RNO-173483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAMBI interferes with the interaction of type I receptor with type II receptor (Rattus norvegicus)
REACT:R-RNO-8858369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVRL1 binds BMP9,BMP10 (Rattus norvegicus)
RHEA:45679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-DDI-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Dictyostelium discoideum)
REACT:R-BTA-6807064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces ZYMOL to ZYMSTNL (Bos taurus)
RHEA:18834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-formylbenzenesulfonate + H2O + NAD(+) => 4-sulfobenzoate + 2 H(+) + NADH
RHEA:58477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Canis familiaris)
RHEA:55117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)
REACT:R-HSA-8938076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD38 hydrolyses NAD+ to NAM and ADP-ribose (Homo sapiens)
REACT:R-HSA-5333612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSebGalNac is oxidatively cleaved to MeSeO2H and 2-acetamidoglucal (Homo sapiens)
REACT:R-SSC-1602446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Sus scrofa)
RHEA:58853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeraniol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH
REACT:R-SCE-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Saccharomyces cerevisiae)
RHEA:40889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octadecanoate + sn-glycerol 3-phosphocholine => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:47490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isodeoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
RHEA:37881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklaviketone => methyl aklanonate
REACT:R-BTA-5362549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np traffics to the plasma membrane (Bos taurus)
RHEA:12363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine <=> 13-(2-methylcrotonoyloxy)lupanine + CoA
RHEA:41487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-BTA-210430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of L-Glutamate at the synapse (Bos taurus)
RHEA:16701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + NADP(+) = estrone + H(+) + NADPH
RHEA:16701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + NAD(+) = estrone + H(+) + NADH
RHEA:16701	skos:prefLabel	"estradiol 17alpha-dehydrogenase"
RHEA:16701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"estradiol 17alpha-dehydrogenase"
GO:0098882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of presynaptic active zone
GO:0098882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of active zone
REACT:R-DRE-1482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by HADH (IM) (Danio rerio)
REACT:R-RNO-909720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN alpha/beta binds to IFNAR2 (Rattus norvegicus)
REACT:R-HSA-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Homo sapiens)
REACT:R-DME-5658430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF1 is degraded by the proteasome (Drosophila melanogaster)
RHEA:27581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N-tert-butylpiperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + tert-butylamine
REACT:R-MMU-9648268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A antagonists (Mus musculus)
REACT:R-XTR-5686924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Xenopus tropicalis)
EC:3.2.1.145	skos:prefLabel	"galactan 1,3-beta-galactosidase"
EC:3.2.1.145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactan 1,3-beta-galactosidase"
REACT:R-SCE-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Saccharomyces cerevisiae)
REACT:R-MMU-373061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR3, 4 and 5 bind CCL5 ligand (Mus musculus)
REACT:R-GGA-983707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates at the activated BCR (Gallus gallus)
RHEA:19943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coclaurine + H(+) + S-adenosyl-L-homocysteine => norcoclaurine + S-adenosyl-L-methionine
REACT:R-MMU-76416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Benzene is hydroxylated to phenol (Mus musculus)
REACT:R-HSA-936951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)
RHEA:29177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 superoxide + ubiquinone-8 => 2 O2 + ubiquinol-8
REACT:R-BTA-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Bos taurus)
REACT:R-XTR-6814409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates PDCL (Xenopus tropicalis)
REACT:R-SCE-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)
REACT:R-MMU-8867370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Mus musculus)
RHEA:35347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O
REACT:R-DRE-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Danio rerio)
REACT:R-HSA-8848338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes TAG (Homo sapiens)
RHEA:52957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyodeoxycholate + UDP-alpha-D-glucuronate => hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP
RHEA:58336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH
REACT:R-GGA-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)
REACT:R-CFA-433131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC1 co-transports dicarboxylic acids and a sodium ion (Canis familiaris)
REACT:R-MMU-8964604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Mus musculus)
RHEA:12261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NADH => ADP + H(+) + NADPH
REACT:R-XTR-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Xenopus tropicalis)
REACT:R-SSC-9036727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAA hydrolyzes lysosomal glycogen (Sus scrofa)
GO:0033900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease F (E. coli) activity
GO:0033900	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase F activity
GO:0033900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease F activity
REACT:R-MMU-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Mus musculus)
REACT:R-RNO-9012657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Rattus norvegicus)
REACT:R-CFA-3769394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CBY1 (Canis familiaris)
REACT:R-DME-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Drosophila melanogaster)
REACT:R-DRE-173542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 ubiquitinates SMAD2 (Danio rerio)
REACT:R-XTR-2424487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)
REACT:R-DME-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Drosophila melanogaster)
RHEA:13237	skos:altLabel	"GlcN6P synthase"
RHEA:13237	skos:prefLabel	"glutamine--fructose-6-phosphate transaminase (isomerizing)"
RHEA:13237	skos:altLabel	"glucosamine-6-phosphate synthase"
RHEA:13237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
RHEA:13237	skos:altLabel	"L-glutamine-D-fructose-6-phosphate amidotransferase"
RHEA:13237	skos:altLabel	"glucosamine-6-phosphate isomerase (glutamine-forming)"
RHEA:13237	skos:altLabel	"hexosephosphate aminotransferase"
RHEA:13237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamine--fructose-6-phosphate transaminase (isomerizing)"
RHEA:13237	skos:altLabel	"D-fructose-6-phosphate amidotransferase"
RHEA:15446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + O-carbamoyl-L-serine => CO2 + 2 NH4(+) + pyruvate
RHEA:51084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-195664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)
REACT:R-GGA-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Gallus gallus)
REACT:R-BTA-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Bos taurus)
EC:1.14.12.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor"
EC:1.14.12.-	skos:prefLabel	"With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor"
RHEA:51992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:51992	skos:altLabel	"(methylthio)alkanaldoxime N-monooxygenase"
RHEA:51992	skos:altLabel	"CYP83A1"
RHEA:51992	skos:prefLabel	"(methylsulfanyl)alkanaldoxime N-monooxygenase"
RHEA:51992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(methylsulfanyl)alkanaldoxime N-monooxygenase"
REACT:R-CEL-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Caenorhabditis elegans)
REACT:R-SSC-917744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA loaded synaptic vesicle Docking and Priming (Sus scrofa)
REACT:R-MMU-9668395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CC2D1B (Mus musculus)
REACT:R-MMU-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Mus musculus)
REACT:R-MMU-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Mus musculus)
REACT:R-RNO-6807052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBP isomerizes ZYMSTNL to LTHSOL (Rattus norvegicus)
REACT:R-SCE-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Saccharomyces cerevisiae)
RHEA:29258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + Na(+)(out) <=> Ca(2+)(out) + Na(+)(in)
RHEA:63824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate = aspulvinone E + H2O
RHEA:72567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(in) + propanoate(out) = dehydroepiandrosterone 3-sulfate(out) + propanoate(in)
REACT:R-SSC-8984021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Sus scrofa)
EC:2.1.1.299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein N-terminal monomethyltransferase"
EC:2.1.1.299	skos:altLabel	"N-terminal monomethylase"
EC:2.1.1.299	skos:prefLabel	"protein N-terminal monomethyltransferase"
REACT:R-XTR-5205867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Xenopus tropicalis)
REACT:R-MMU-205286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS interacts with p-KIT (Mus musculus)
RHEA:13022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + vanillate => 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)
RHEA:51607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-400682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Rac1 interacts with Plexin-B1:Sema4D (Bos taurus)
REACT:R-CFA-1250220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of ERBB4 (Canis familiaris)
REACT:R-HSA-174491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of trimeric ENV precursor to Golgi apparatus (Homo sapiens)
RHEA:64312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride + 2 FADH2 + 2 O2 + sulochrin = dihydrogeodin + 2 FAD + H(+) + 4 H2O
RHEA:44949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)
REACT:R-HSA-9629918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 translocates to the nucleus (Homo sapiens)
GO:0140952	skos:prefLabel	"[histone H3]-lysine(27) N-dimethyltransferase"
GO:0140952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 dimethylase activity
GO:0140952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine
GO:0140952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-dimethyltransferase activity (H3-K27 specific)
GO:0140952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 dimethyltransferase activity
GO:0140952	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K27 dimethylation
GO:0140952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K27 dimethylase activity
GO:0140952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(27) N-dimethyltransferase"
GO:0140952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 mono/dimethylase activity
GO:0140952	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K27 dimethylation
RHEA:50749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juglone => naphthalene-1,2,4,8-tetrol
REACT:R-XTR-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Xenopus tropicalis)
RHEA:36687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-hexadecanoylsphing-4-enine
GO:0034792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypophosphite dioxygenase activity
REACT:R-HSA-174959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT1 (Homo sapiens)
REACT:R-DME-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Drosophila melanogaster)
REACT:R-RNO-2562594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated OPTN translocates to the nucleus (Rattus norvegicus)
REACT:R-XTR-77271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Xenopus tropicalis)
REACT:R-HSA-9682631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp13 binds DDX5 (Homo sapiens)
REACT:R-SSC-194310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Sus scrofa)
RHEA:55816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine
REACT:R-PFA-71495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate (Plasmodium falciparum)
REACT:R-HSA-1462014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-defensins form biologically active dimers (Homo sapiens)
REACT:R-CEL-373732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin trans-homophilic interaction (Caenorhabditis elegans)
REACT:R-SSC-5654573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds SHC1 (Sus scrofa)
GO:1903777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose binding
RHEA:20011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + linamarin + UDP => 2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose
REACT:R-XTR-443831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3-zeta binds Raf1 (Xenopus tropicalis)
RHEA:12724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + S-methyl-5'-thioadenosine + spermidine
REACT:R-SSC-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Sus scrofa)
GO:0034866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,4-trimethylpentanoyl-CoA dehydrogenase activity
REACT:R-XTR-5578966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A:AGO2:miRNA is transported into the nucleus (Xenopus tropicalis)
REACT:R-BTA-1475032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Bos taurus)
RHEA:68987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine
RHEA:43257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate
REACT:R-CEL-372505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylcholine synaptic vesicle docking and priming (Caenorhabditis elegans)
REACT:R-BTA-77591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Bos taurus)
REACT:R-GGA-5694082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XK:KEL:Zn2+ cleaves EDN3 (Gallus gallus)
RHEA:15971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + H2O + methylarsonous acid => 2 glutathione + H(+) + methylarsonate
RHEA:15784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine <=> 3-amino-3-(4-hydroxyphenyl)propanoate
REACT:R-XTR-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Xenopus tropicalis)
RHEA:54079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + stellata-2,6,19-triene
REACT:R-BTA-9686930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is cleaved by CASP8 (Bos taurus)
REACT:R-MMU-8849900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs1-3 bind each other in cis interactions (Mus musculus)
REACT:R-MMU-388829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 phosphatase binds CTLA-4 (Mus musculus)
GO:0002020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protease binding
GO:0002020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acrosin Cleavage (Homo sapiens)
RHEA:66224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-C9-CoA + O2 = asc-DeltaC9-CoA + H2O2
REACT:R-PFA-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Plasmodium falciparum)
REACT:R-DRE-451283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kainate receptor binds glutamate (Danio rerio)
RHEA:23852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + O2 = cis,cis-muconate + 2 H(+)
RHEA:23852	skos:prefLabel	"catechol 1,2-dioxygenase"
RHEA:23852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"catechol 1,2-dioxygenase"
RHEA:23852	skos:altLabel	"pyrocatechase"
RHEA:23852	skos:altLabel	"catechase"
REACT:R-BTA-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Bos taurus)
RHEA:20732	skos:prefLabel	"thioredoxin:protein disulfide reductase"
RHEA:20732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thioredoxin:protein disulfide reductase"
RHEA:20732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + [thioredoxin]-disulfide = [protein]-disulfide + [thioredoxin]-dithiol
RHEA:12871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + diphosphate => (2E)-geranyl diphosphate
GO:0103054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming)
RHEA:63458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+) => (2E,6E,10E)-geranylgeraniol + CTP
RHEA:30678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahymanol <=> H2O + squalene
REACT:R-DME-9627104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP3 (Drosophila melanogaster)
RHEA:29615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltotriose + beta-maltose = alpha-maltotetraose + beta-D-glucose
RHEA:66458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:0033569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactoferrin transmembrane transporter activity
REACT:R-HSA-5250616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
RHEA:31154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-selenocystathionine <=> 2-oxobutanoate + L-selenocysteine + NH4(+)
REACT:R-GGA-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Gallus gallus)
REACT:R-BTA-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Bos taurus)
RHEA:49023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide
REACT:R-HSA-1236938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Partial proteolysis of antigen in phagolysosomes (Homo sapiens)
REACT:R-SSC-166168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Sus scrofa)
REACT:R-BTA-9710254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME oligomerizes (Bos taurus)
REACT:R-HSA-5687094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 phosphorylate MAPKAPK5 (Homo sapiens)
REACT:R-HSA-5654729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Homo sapiens)
RHEA:10760	skos:altLabel	"citridesmolase"
RHEA:10760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate = acetate + oxaloacetate
RHEA:10760	skos:altLabel	"citrate lyase"
RHEA:10760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citrate (pro-3S)-lyase"
RHEA:10760	skos:altLabel	"citrate aldolase"
RHEA:10760	skos:altLabel	"citrase"
RHEA:10760	skos:prefLabel	"citrate (pro-3S)-lyase"
RHEA:10760	skos:altLabel	"citritase"
RHEA:10760	skos:altLabel	"citratase"
RHEA:41934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + holo-[ACP] => H2O + hexadecanoyl-[ACP]
REACT:R-DME-209298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BSK is phosphorylated and activated by phosphorylated HEP kinase (Drosophila melanogaster)
REACT:R-RNO-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Rattus norvegicus)
REACT:R-MMU-5683405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP5C dephosphorylates TP53BP1 (Mus musculus)
REACT:R-SCE-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Saccharomyces cerevisiae)
REACT:R-HSA-9007625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBBP8 gene expression is inhibited by E2F6 (Homo sapiens)
RHEA:18476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + ATP
REACT:R-DDI-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Dictyostelium discoideum)
REACT:R-XTR-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Xenopus tropicalis)
REACT:R-BTA-111966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 binds CALM1:4Ca2+ (Bos taurus)
REACT:R-HSA-5625674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-GGA-5691411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Gallus gallus)
RHEA:13251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopropyl-coenzyme M + H(+) + NADH => (R)-2-hydroxypropyl-coenzyme M + NAD(+)
REACT:R-SPO-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)
REACT:R-HSA-9664940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
RHEA:40118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanoyl-CoA <=> CoA + H(+) + hexanoate
GO:0140486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc ion sequestering activity
RHEA:63295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine
REACT:R-RNO-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Rattus norvegicus)
RHEA:48807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
REACT:R-MMU-202541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)
RHEA:46237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:51465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-2995334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX15 transforms heme O to heme A (Homo sapiens)
RHEA:68780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = alpha-humulene + diphosphate
REACT:R-MMU-9677320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS1 dimer binds PTGS1 Inhibitors (Mus musculus)
REACT:R-HSA-8987120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IFNLR1 (Homo sapiens)
REACT:R-SPO-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Schizosaccharomyces pombe)
RHEA:72395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) + K(+)(in) + Na(+)(in)
GO:0050693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBD domain binding
GO:0050693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand binding domain binding
REACT:R-CFA-2514831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP14 (Canis familiaris)
RHEA:58903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-carboxybiuret + H2O <=> NH4(+) + urea-1,3-dicarboxylate
REACT:R-CFA-8956031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Canis familiaris)
RHEA:32982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-L-serine
REACT:R-CEL-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)
REACT:R-CFA-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Canis familiaris)
REACT:R-MMU-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
REACT:R-DME-3769383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBY1 binds beta-catenin (Drosophila melanogaster)
REACT:R-RNO-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Rattus norvegicus)
REACT:R-SPO-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Schizosaccharomyces pombe)
REACT:R-BTA-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Bos taurus)
REACT:R-CFA-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Canis familiaris)
REACT:R-XTR-194023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2,HSD11B1 dimer oxidise CORT to COR (Xenopus tropicalis)
REACT:R-XTR-9624272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMPs cleave HB-EGF (Xenopus tropicalis)
REACT:R-DRE-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Danio rerio)
GO:0035184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone threonine kinase activity
GO:0035184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-threonine kinase activity
REACT:R-SPO-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Schizosaccharomyces pombe)
RHEA:61917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + fluconazole(in) + H2O => ADP + fluconazole(out) + H(+) + phosphate
REACT:R-CEL-173597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)
RHEA:45700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + H(+) + NADH + O2 = formaldehyde + H2O + N,N-dimethylglycine + NAD(+)
REACT:R-DDI-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Dictyostelium discoideum)
RHEA:65390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O
RHEA:44570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-hexaprenylphenol + CO2 => 4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+)
RHEA:34775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH
GO:0003922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine monophosphate synthetase (glutamine-hydrolyzing)
GO:0003922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GMP synthetase (glutamine-hydrolysing)
GO:0003922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GMP synthetase (glutamine-hydrolyzing) activity
GO:0003922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
GO:0003922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GMP synthase (glutamine-hydrolysing)
GO:0003922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanylate synthetase (glutamine-hydrolyzing)
GO:0003922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-monophosphate synthetase activity
GO:0003922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine amidotransferase activity
GO:0003922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthosine 5'-phosphate amidotransferase activity
GO:0003922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP synthase (glutamine-hydrolyzing) activity
REACT:R-SSC-6795667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the cytosol (Sus scrofa)
REACT:R-DME-1295634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is serine phosphorylated in response to MAPK activation (Drosophila melanogaster)
REACT:R-RNO-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Rattus norvegicus)
RHEA:41150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
GO:0061501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP = 2',3'-cGAMP + 2 diphosphate
GO:0061501	skos:prefLabel	"cyclic GMP-AMP synthase"
GO:0061501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3' cyclic GMP-AMP synthase activity
GO:0061501	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclic-GMP-AMP synthase activity
GO:0061501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclic GMP-AMP synthase activity
GO:0061501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclic GMP-AMP synthase"
GO:0061501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic 2',3' GAMP synthase activity
GO:0061501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3' cyclic-GMP-AMP synthase activity
REACT:R-MMU-71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Mus musculus)
RHEA:72611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-lysine(out) = H(+)(in) + L-alanyl-L-lysine(in)
REACT:R-MMU-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Mus musculus)
RHEA:30258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinol + O2 <=> 2 a ubiquinone + 2 H2O
RHEA:68272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + L-seryl-[protein] = CoA + O-fatty acyl-L-seryl-[protein]
REACT:R-XTR-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)
REACT:R-DRE-6799981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 binds bacterial peptidoglycan (Danio rerio)
REACT:R-SSC-3465448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at DISC (Sus scrofa)
REACT:R-CEL-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Caenorhabditis elegans)
REACT:R-SSC-174097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdh1 (Sus scrofa)
RHEA:19392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + ADP + phosphate
REACT:R-GGA-163010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Down Regulation of Emi1 through Phosphorylation of Emi1 (Gallus gallus)
REACT:R-RNO-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Rattus norvegicus)
REACT:R-BTA-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Bos taurus)
REACT:R-CFA-5693055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)
REACT:R-BTA-158278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Bos taurus)
REACT:R-CEL-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Caenorhabditis elegans)
REACT:R-MMU-5624951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNPO1 binds KIF17 dimer (Mus musculus)
RHEA:39019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
RHEA:39019	skos:altLabel	"PtdIns-3,5-P2 3-Ptase"
RHEA:39019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol-3,5-bisphosphate 3-phosphatase"
RHEA:39019	skos:prefLabel	"phosphatidylinositol-3,5-bisphosphate 3-phosphatase"
GO:0043120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tumor necrosis factor binding
REACT:R-DRE-983194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-1 is a heterotetramer (Danio rerio)
RHEA:45723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hexadecanoylsphing-4-enine(in) <=> N-hexadecanoylsphing-4-enine(out)
RHEA:34987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(in) = (S)-lactate(out)
RHEA:48953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) => 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH
GO:0102749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrogeranylgeranyl-chlorophyll a reductase activity
REACT:R-SPO-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Schizosaccharomyces pombe)
RHEA:71430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)
RHEA:29486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-beta-selinene + diphosphate
RHEA:51215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH
REACT:R-GGA-5668543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3:NIK binds TRAF2:cIAP1/2 (Gallus gallus)
REACT:R-DRE-2025724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Danio rerio)
REACT:R-CFA-5687673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN recruits LIG3:XRCC1 to MMEJ sites (Canis familiaris)
REACT:R-MMU-388560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA,EDNRB bind EDNs (Mus musculus)
REACT:R-DME-74059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Drosophila melanogaster)
REACT:R-CFA-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Canis familiaris)
REACT:R-XTR-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Xenopus tropicalis)
REACT:R-BTA-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Bos taurus)
REACT:R-SSC-435244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM1 is phosphorylated (Sus scrofa)
RHEA:23392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(n-1) H2O + RNA(n) = n a ribonucleoside 5'-phosphate + n H(+)
RHEA:12321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-O-acetylnorajmaline + NADP(+) => 1,2-dihydrovomilenine + 2 H(+) + NADPH
RHEA:49118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyviolaceinate + H2O + NADP(+) => H(+) + NADPH + O2 + protodeoxyviolaceinate
RHEA:64615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Gln) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)
RHEA:45243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3E,5Z)-dienoyl-CoA <=> a (2E,4E)-(5,6-saturated)-dienoyl-CoA
GO:0004038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoinase activity
GO:0004038	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-allantoin amidohydrolase activity
REACT:R-CFA-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Canis familiaris)
REACT:R-HSA-2022405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
RHEA:67593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end CoA-ribonucleoside in mRNA + H2O => (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)
RHEA:41428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-tyrosine C(3)-methyltransferase"
RHEA:41428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + S-adenosyl-L-methionine = 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine
RHEA:41428	skos:prefLabel	"L-tyrosine C(3)-methyltransferase"
RHEA:15756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + IMP + L-aspartate <=> GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate
REACT:R-RNO-9708866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-F2R binds vorapaxar (Rattus norvegicus)
RHEA:33342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine
RHEA:67102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumigatonoid C => fumigatonoid B
REACT:R-SSC-165692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of 4E-BP1 by activated mTORC1 (Sus scrofa)
REACT:R-SSC-6784628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Sus scrofa)
REACT:R-MMU-112271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex dissociates (Mus musculus)
REACT:R-DRE-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Danio rerio)
RHEA:30265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 monodehydro-L-ascorbate radical => H2O2 + 2 L-ascorbate
RHEA:60849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]
REACT:R-RNO-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Rattus norvegicus)
REACT:R-XTR-8851933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates GAB1 (Xenopus tropicalis)
RHEA:43987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)
RHEA:18223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O
RHEA:51707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthohumol <=> 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine
GO:0052685	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	perillyl-CoA synthetase activity
GO:0052685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	perillic acid:CoA ligase (ADP-forming) activity
GO:0052685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	perillic acid-CoA ligase (ADP-forming) activity
REACT:R-SPO-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)
REACT:R-BTA-5625849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM1A binds KLK2 and KLK3 promoters (Bos taurus)
RHEA:38137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol
REACT:R-RNO-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Rattus norvegicus)
REACT:R-BTA-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Bos taurus)
RHEA:35811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (-)-medicarpin + H2O
RHEA:65307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + verruculide A <=> chrodrimanin T + CO2 + succinate
RHEA:59326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,5-lactone + H2O2 => D-xylose + O2
REACT:R-SSC-174551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of alternative pathway C5 convertase (Sus scrofa)
REACT:R-CFA-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Canis familiaris)
REACT:R-MMU-5357479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AXL binds PI3K (Mus musculus)
REACT:R-SSC-193650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR binds to NADE (Sus scrofa)
REACT:R-DDI-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)
REACT:R-GGA-156661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Exon Junction Complex (Gallus gallus)
RHEA:30264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + 2 L-ascorbate => 2 H2O + 2 monodehydro-L-ascorbate radical
RHEA:61129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + quercetin + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]
RHEA:21810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycylglycine => 2,5-dioxopiperazine + H2O
REACT:R-BTA-8954110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1:EPC1 binds the PRC2 complex (Bos taurus)
RHEA:23824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"
RHEA:23824	skos:prefLabel	"2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"
RHEA:23824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH
RHEA:23824	skos:altLabel	"2,3-DHB dehydrogenase"
REACT:R-GGA-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
REACT:R-GGA-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Gallus gallus)
REACT:R-RNO-9688456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds FLOT1, FLOT2 (Rattus norvegicus)
RHEA:24631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 3 NAD(+) + NH4(+) <=> 5 H(+) + 3 NADH + nitrite
REACT:R-GGA-8987014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Gallus gallus)
REACT:R-CFA-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Canis familiaris)
REACT:R-RNO-877281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 binds p-STAT1 dimer (Rattus norvegicus)
RHEA:15020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phosphate monoester + H2O <=> an alcohol + phosphate
RHEA:29261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate(in) + succinate(out) => (2R,3R)-tartrate(out) + succinate(in)
REACT:R-MMU-2454081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5 oxidises 11cROL to 11cRAL (Mus musculus)
REACT:R-RNO-2574840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA facilitates AURKA autophosphorylation (Rattus norvegicus)
RHEA:23243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate
REACT:R-HSA-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Homo sapiens)
REACT:R-SSC-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Sus scrofa)
RHEA:23369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phenylglyoxylate => benzaldehyde + CO2
REACT:R-CFA-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)
GO:0015234	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin uptake transporter activity
GO:0015234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine transmembrane transporter activity
GO:0015234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin transmembrane transporter activity
GO:0015234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B1 transporter activity
GO:0015234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine permease activity
GO:0015234	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine uptake transmembrane transporter activity
GO:0015234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin permease activity
REACT:R-MMU-561054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular secretion of organic cations in the kidney (Mus musculus)
RHEA:44619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)
RHEA:67385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (1R,5R)-sabinene + diphosphate
REACT:R-MMU-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Mus musculus)
REACT:R-CEL-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Caenorhabditis elegans)
REACT:R-HSA-265427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Homo sapiens)
REACT:R-CFA-354165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
REACT:R-XTR-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Xenopus tropicalis)
RHEA:71472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P => L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)
RHEA:12452	skos:altLabel	"inositol-trisphosphate 6-kinase"
RHEA:12452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-tetrakisphosphate 1-kinase"
RHEA:12452	skos:altLabel	"1D-myo-inositol-trisphosphate 6-kinase"
RHEA:12452	skos:altLabel	"inositol-trisphosphate 5-kinase"
RHEA:12452	skos:altLabel	"1D-myo-inositol-trisphosphate 5-kinase"
RHEA:12452	skos:prefLabel	"inositol-tetrakisphosphate 1-kinase"
RHEA:12452	skos:altLabel	"1D-myo-inositol-tetrakisphosphate 1-kinase"
RHEA:12452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
REACT:R-XTR-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Xenopus tropicalis)
GO:0018763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyatrazine ethylaminohydrolase activity
GO:0018763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxydechloroatrazine ethylaminohydrolase activity
GO:0018763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyatrazine hydrolase activity
GO:0018763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AtzB
GO:0018763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity
REACT:R-RNO-446322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVA associates with Paxillin (Rattus norvegicus)
REACT:R-BTA-265422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaEbeta7 with Cadherin-1 (Bos taurus)
REACT:R-SCE-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Saccharomyces cerevisiae)
REACT:R-HSA-8950398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX dissociates from IL27:EBI3 (Homo sapiens)
RHEA:10548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginine 2-monooxygenase"
RHEA:10548	skos:altLabel	"arginine oxygenase (decarboxylating)"
RHEA:10548	skos:altLabel	"arginine decarboxylase"
RHEA:10548	skos:altLabel	"arginine decarboxy-oxidase"
RHEA:10548	skos:prefLabel	"arginine 2-monooxygenase"
RHEA:10548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O
RHEA:15856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADH
RHEA:62005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)
RHEA:10318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethyluracil + CO2 + succinate => 2-oxoglutarate + O2 + thymine
RHEA:70362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-3-oxosphinganine
REACT:R-MMU-8987040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Mus musculus)
REACT:R-SSC-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Sus scrofa)
RHEA:21158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + phosphate => (2R)-2-phosphoglycerate + H2O
RHEA:63481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha => 15-oxoprostaglandin F2alpha + H(+) + NADPH
REACT:R-GGA-9011949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Gallus gallus)
REACT:R-SSC-6805276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates TP53 (Sus scrofa)
RHEA:57284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA
REACT:R-DDI-8876446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ULK1 phosphorylates DENND3 (Dictyostelium discoideum)
REACT:R-RNO-193641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKK-beta is recruited (Rattus norvegicus)
GO:0030345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of tooth enamel
RHEA:54667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene <=> pre-alpha-onocerin
REACT:R-RNO-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Rattus norvegicus)
RHEA:58280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 ATP = cyclic tetraadenylate + 4 diphosphate
RHEA:15551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => S-methyl-5-thio-D-ribulose 1-phosphate
RHEA:56533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate
REACT:R-SSC-9691566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 binds nicorandil (Sus scrofa)
REACT:R-HSA-5672019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa (Homo sapiens)
RHEA:49278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP + phytyl diphosphate => CTP + phytyl phosphate
RHEA:23769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + sphing-4-enine => an N-acylsphing-4-enine + CoA + H(+)
RHEA:11220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine
RHEA:64160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thioglycine synthase"
RHEA:64160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide = ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]
RHEA:64160	skos:prefLabel	"thioglycine synthase"
RHEA:63826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspulvinone E + H2O => 2 3-(4-hydroxyphenyl)pyruvate
REACT:R-SCE-8862380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B13 binds lipid droplets (Saccharomyces cerevisiae)
REACT:R-SSC-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Sus scrofa)
RHEA:44092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + nonadecanoate = AMP + diphosphate + nonadecanoyl-CoA
REACT:R-SSC-8955289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
REACT:R-HSA-194036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cortisol translocates from the mitochondrial matrix to the cytosol (Homo sapiens)
RHEA:48935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1b <=> CMP + ganglioside GQ1b + H(+)
REACT:R-BTA-5661124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR4-HIST1H4 (Bos taurus)
REACT:R-HSA-9611839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β3-agonists bind ADRB3 (Homo sapiens)
GO:0003968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-directed RNA polymerase activity
GO:0003968	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transcriptase
GO:0003968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-dependent RNA polymerase activity
GO:0003968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA replicase activity
GO:0003968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA nucleotidyltransferase (RNA-directed) activity
GO:0003968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-directed 5'-3' RNA polymerase activity
GO:0003968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RdRP activity
GO:0003968	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA synthetase activity
GO:0003968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-dependent RNA replicase activity
RHEA:46370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:27354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-demethylrebeccamycin + S-adenosyl-L-methionine => H(+) + rebeccamycin + S-adenosyl-L-homocysteine
RHEA:33789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-keto-beta-D-galactose + beta-D-glucose => 3'-ketolactose + H2O
REACT:R-CFA-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Canis familiaris)
REACT:R-MMU-8938300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vanin hydrolyses pantetheine to PanK, 2AET (Mus musculus)
REACT:R-DME-2065550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds Importin beta-1 (Drosophila melanogaster)
REACT:R-SCE-114684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Syntaxin-4 (Saccharomyces cerevisiae)
REACT:R-DME-446083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD151 interacts with BP180 and the integrin alpha 6 subunit (Drosophila melanogaster)
RHEA:69764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty aldehyde + H2O + NAD(+) => a medium chain fatty acid + 2 H(+) + NADH
GO:0016749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-succinyltransferase activity
GO:0005105	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 fibroblast growth factor receptor ligand
GO:0005105	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	breathless ligand
GO:0005105	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FGFR1 ligand
GO:0005105	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	breathless binding
GO:0005105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 fibroblast growth factor receptor binding
GO:0005105	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	FGFR1 binding
REACT:R-SCE-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Saccharomyces cerevisiae)
GO:1990715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA coding region binding
GO:1990715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA CDS binding
GO:1990715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA coding sequence binding
REACT:R-BTA-114542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1,RAC2,RHOG activate PI3K (Bos taurus)
RHEA:61923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-ketoconazole(in) + ATP + H2O <=> (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate
REACT:R-DDI-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Dictyostelium discoideum)
GO:0004078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-methylcrotonoyl-CoA-carboxylase ligase activity
GO:0004078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
GO:0004078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity
GO:0004078	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	biotin-methylcrotonoyl-CoA-carboxylase synthetase
GO:0004078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity
GO:0004078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity
GO:0004078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
RHEA:26076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucuronate <=> D-glucuronate + H(+) + UDP
REACT:R-SSC-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Sus scrofa)
REACT:R-CEL-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Caenorhabditis elegans)
REACT:R-SSC-193665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYD88 dissociates (Sus scrofa)
REACT:R-HSA-204392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Basigin binds MCT1, MCT3 and MCT4 (Homo sapiens)
REACT:R-HSA-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)
REACT:R-MMU-5624131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B binds myristoylated proteins (Mus musculus)
RHEA:21303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate
REACT:R-BTA-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Bos taurus)
RHEA:41840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)
RHEA:19409	skos:prefLabel	"7alpha-hydroxysteroid dehydrogenase"
RHEA:19409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7alpha-hydroxysteroid dehydrogenase"
RHEA:19409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH
REACT:R-MMU-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Mus musculus)
REACT:R-BTA-2453833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Bos taurus)
GO:0015594	skos:altLabel	"putrescine ABC transporter"
GO:0015594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type putrescine transporter activity
GO:0015594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + putrescine(out) = ADP + H(+) + phosphate + putrescine(in)
GO:0015594	skos:prefLabel	"ABC-type putrescine transporter"
GO:0015594	skos:altLabel	"putrescine transporting ATPase"
GO:0015594	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	putrescine porter activity
GO:0015594	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	putrescine-importing ATPase activity
GO:0015594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type putrescine transporter"
GO:0015594	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled putrescine transmembrane transporter activity
REACT:R-DDI-2172666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds condensin II (Dictyostelium discoideum)
REACT:R-BTA-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Bos taurus)
REACT:R-CFA-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Canis familiaris)
REACT:R-XTR-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Xenopus tropicalis)
RHEA:62222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neopatulin => phyllostine
REACT:R-GGA-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Gallus gallus)
RHEA:15878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + pyridoxamine 5'-phosphate => D-glutamate + pyridoxal 5'-phosphate
RHEA:60779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A12 + O2 <=> CO2 + gibberellin A15 + succinate
RHEA:20963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate
RHEA:41312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate
RHEA:31715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:69473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose => a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]
REACT:R-SSC-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Sus scrofa)
EC:5.6.1.6	skos:prefLabel	"channel-conductance-controlling ATPase"
EC:5.6.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"channel-conductance-controlling ATPase"
EC:5.6.1.6	skos:altLabel	"cystic-fibrosis membrane-conductance-regulating protein"
EC:5.6.1.6	skos:altLabel	"CFTR"
RHEA:49404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate = alpha-D-mannose 1-phosphate + D-mannose
RHEA:49404	skos:prefLabel	"beta-1,2-mannobiose phosphorylase"
RHEA:49404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-1,2-mannobiose phosphorylase"
GO:0061749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	forked DNA-dependent helicase activity
GO:0009026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	altronic oxidoreductase activity
GO:0009026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	altronate oxidoreductase activity
GO:0009026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tagaturonate reductase activity
GO:0009026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-altronate:NAD+ 3-oxidoreductase activity
GO:0009026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	altronate dehydrogenase activity
GO:0009026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TagUAR
GO:0009026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-tagaturonate reductase activity
GO:0009026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tagaturonate dehydrogenase activity
REACT:R-HSA-4396382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 Coactivator Complex binds promoters of HEY genes (Homo sapiens)
RHEA:46034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate
REACT:R-CFA-8983872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Canis familiaris)
REACT:R-MMU-982807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation of GHR (Mus musculus)
RHEA:17854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-sorbose + O2 => 5-dehydro-D-fructose + H2O2
REACT:R-DDI-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Dictyostelium discoideum)
REACT:R-XTR-351210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Xenopus tropicalis)
RHEA:23455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + ATP <=> ADP + dAMP + H(+)
REACT:R-BTA-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Bos taurus)
REACT:R-CFA-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Canis familiaris)
RHEA:18312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-amino acid + H2O <=> a carboxylate + a D-alpha-amino acid
REACT:R-CFA-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Canis familiaris)
REACT:R-DRE-2028735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind WWTR1 (TAZ) (Danio rerio)
REACT:R-SSC-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Sus scrofa)
RHEA:55489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:37561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-CFA-416639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Canis familiaris)
REACT:R-DRE-211178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO1A is excluded from the nucleus (Danio rerio)
REACT:R-DME-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Drosophila melanogaster)
RHEA:28511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arbutin 6-phosphate + H2O => beta-D-glucose 6-phosphate + hydroquinone
REACT:R-CEL-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)
GO:1990817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA adenylyltransferase activity
RHEA:64573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyl diphosphate + neryl diphosphate => (2Z,6Z)-farnesyl diphosphate + diphosphate
REACT:R-GGA-5687673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN recruits LIG3:XRCC1 to MMEJ sites (Gallus gallus)
RHEA:60569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-tryptophan => N-acetyl-D-tryptophan
REACT:R-SSC-9648983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Sus scrofa)
REACT:R-DRE-9634584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Danio rerio)
RHEA:59013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloartenol + S-adenosyl-L-methionine => 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Danio rerio)
RHEA:60457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UTP => 3',3'-cUAMP + 2 diphosphate
REACT:R-XTR-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Xenopus tropicalis)
RHEA:32813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate(out) => benzoate(in)
RHEA:59549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N',N''-triacetylchitotriose + O2 => H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone
REACT:R-HSA-159566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Homo sapiens)
REACT:R-DRE-6781899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds SIAH2 (Danio rerio)
REACT:R-HSA-4649028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE forms non-functional complexes with AES (Homo sapiens)
GO:0016706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0016706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate dioxygenase activity
GO:0016706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate-dependent dioxygenase activity
REACT:R-HSA-5228408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde transport of internalized tetX HC:LC:gangliosides (Homo sapiens)
REACT:R-SSC-8938770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Sus scrofa)
REACT:R-GGA-443978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR11 binds CCL19, CCL21 & CCL25 (Gallus gallus)
REACT:R-BTA-5668714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX1 complex (Bos taurus)
RHEA:35727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA
RHEA:72520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate => 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)
RHEA:48655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:3.4.22.43	skos:altLabel	"cathepsin U"
EC:3.4.22.43	skos:altLabel	"cathepsin L2"
EC:3.4.22.43	skos:prefLabel	"cathepsin V"
EC:3.4.22.43	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin V"
REACT:R-MMU-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Mus musculus)
RHEA:59686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaono-1,5-lactone + H2O2 => D-maltohexaose + O2
RHEA:44719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-4,4'-diapolycopen-4-al + H2O <=> AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)
RHEA:51794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate
REACT:R-BTA-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Bos taurus)
RHEA:18290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate => H2O + oxaloacetate
RHEA:50655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O
RHEA:62278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine => 3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine
RHEA:30063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + S-adenosyl-L-methionine = H(+) + menaquinol-8 + S-adenosyl-L-homocysteine
REACT:R-DRE-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Danio rerio)
REACT:R-RNO-8854897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Rattus norvegicus)
REACT:R-DRE-977615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates MCP/CR1-bound C4b/C3b (Danio rerio)
REACT:R-GGA-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Gallus gallus)
GO:0043837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	valine dehydrogenase (NAD) activity
GO:0043837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ValDH
REACT:R-GGA-201486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand pleiotrophin (PTN) (Gallus gallus)
GO:0047507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleoside monophosphokinase activity
GO:0047507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxynucleoside-5'-monophosphate kinase activity
GO:0047507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:deoxynucleoside-phosphate phosphotransferase activity
GO:0047507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)nucleoside-phosphate kinase activity
GO:0047507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxynucleoside monophosphate kinase activity
RHEA:40130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-3229138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription (Homo sapiens)
REACT:R-SSC-432143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM-1 binds PP2A (Sus scrofa)
REACT:R-XTR-1562641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)
REACT:R-RNO-110376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Rattus norvegicus)
REACT:R-XTR-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Xenopus tropicalis)
RHEA:46520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-XTR-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Xenopus tropicalis)
REACT:R-DRE-8940070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NAD+ (Danio rerio)
REACT:R-MMU-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Mus musculus)
RHEA:44089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + heptanoate => AMP + diphosphate + heptanoyl-CoA
REACT:R-CFA-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Canis familiaris)
RHEA:63454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H(+) + oxidized 3PG-factor420-0 => 3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin
RHEA:19842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:21309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => cycloartenol
RHEA:26551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-piperazine-2-carboxamide + H2O => (S)-piperazine-2-carboxylate + NH4(+)
GO:0018520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity
GO:0018520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)
GO:0018520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
REACT:R-CFA-2046097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)
REACT:R-CEL-870477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Caenorhabditis elegans)
REACT:R-SSC-2022398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Sus scrofa)
REACT:R-SSC-377641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clustering of Integrin alphaIIb beta3 complexes (Sus scrofa)
RHEA:37150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-CFA-111238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR2  homodimer (Canis familiaris)
REACT:R-BTA-1433395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of sSCF (Bos taurus)
RHEA:51891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH
REACT:R-BTA-351876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of occludin (Bos taurus)
REACT:R-HSA-8948034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds LDL:LRP8 (Homo sapiens)
REACT:R-CEL-6787321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DERA cleaves dR5P to GA3P and CH3CHO (Caenorhabditis elegans)
REACT:R-CFA-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
REACT:R-DME-420977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca permeable AMPA receptor ligand binding (Drosophila melanogaster)
RHEA:61146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP => myricetin + UDP-beta-L-rhamnose
GO:0005460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose transmembrane transporter activity
RHEA:72107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-acyl-(R)-carnitine(out) = Na(+)(in) + O-acyl-(R)-carnitine(in)
RHEA:39328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O
GO:0015566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acriflavin transporter activity
GO:0015566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acriflavine transmembrane transporter activity
GO:0015566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acriflavine transporter activity
GO:0015566	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acriflavin resistant pump activity
REACT:R-CEL-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Caenorhabditis elegans)
REACT:R-MMU-210881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Tie2/Ang1 complex (Mus musculus)
REACT:R-DRE-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)
RHEA:29462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(in) + H(+)(in) <=> beta-alanine(out) + H(+)(out)
RHEA:15835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + CO2 + H2O2 => (S)-4-hydroxymandelate + H(+) + O2
REACT:R-DME-8933452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE dimer binds phosphorylated DENND1 proteins (Drosophila melanogaster)
REACT:R-XTR-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Xenopus tropicalis)
GO:0034520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-naphthaldehyde dehydrogenase activity
REACT:R-DME-1254386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 forms a complex with estrogen receptor ESR1 (Drosophila melanogaster)
REACT:R-SSC-8855747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Sus scrofa)
REACT:R-CEL-187688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Caenorhabditis elegans)
REACT:R-SSC-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Sus scrofa)
REACT:R-DRE-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Danio rerio)
RHEA:37839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CEL-975916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 5 by MGAT5 (Caenorhabditis elegans)
GO:0018566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
GO:0018566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity
REACT:R-DRE-873927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of STAT1 dimer from active receptor unit (Danio rerio)
REACT:R-DDI-2161768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXA4 is converted to EXC4 by LTC4S (Dictyostelium discoideum)
REACT:R-CEL-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Caenorhabditis elegans)
GO:0050385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ureidoglycolate lyase activity
GO:0050385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ureidoglycolatase activity
GO:0050385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ureidoglycolate hydrolase activity
GO:0050385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-ureidoglycolate urea-lyase activity
GO:0050385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-ureidoglycolate urea-lyase (glyoxylate-forming)
GO:0050385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ureidoglycolase activity
RHEA:42937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(32) in tRNA => 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:60904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 = 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
RHEA:66786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out)
REACT:R-HSA-5323526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRAT proteins bind GSK3beta (Homo sapiens)
RHEA:72968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) => 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)
GO:0047010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity
GO:0047010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxycyclohexanecarboxylate dehydrogenase activity
GO:0047010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH
GO:0047010	skos:prefLabel	"hydroxycyclohexanecarboxylate dehydrogenase"
GO:0047010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxycyclohexanecarboxylate dehydrogenase activity
GO:0047010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxycyclohexanecarboxylate dehydrogenase"
GO:0047010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity
REACT:R-RNO-9632412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 is recruited to methylated ESR1 (Rattus norvegicus)
REACT:R-DRE-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Danio rerio)
REACT:R-XTR-1236955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Movement of clathrin coated vesicles into early endosome (Xenopus tropicalis)
GO:0103064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol phosphorylceramide mannosyltransferase activity
RHEA:40068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)
REACT:R-HSA-9605060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SCD regulated by NR1H2 or NR1H3 (Homo sapiens)
REACT:R-CFA-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Canis familiaris)
REACT:R-DME-6814374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kazrin binds periplakin (Drosophila melanogaster)
EC:1.1.3.4	skos:altLabel	"beta-D-glucose:oxygen 1-oxido-reductase"
EC:1.1.3.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose oxidase"
EC:1.1.3.4	skos:altLabel	"D-glucose-1-oxidase"
EC:1.1.3.4	skos:altLabel	"GOD"
EC:1.1.3.4	skos:prefLabel	"glucose oxidase"
EC:1.1.3.4	skos:altLabel	"glucose aerodehydrogenase"
EC:1.1.3.4	skos:altLabel	"glucose oxyhydrase"
GO:0031834	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurokinin receptor ligand
GO:0031834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurokinin receptor binding
REACT:R-HSA-1067646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2,(TYK2) bind IL6ST (Homo sapiens)
REACT:R-RNO-5672954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Rattus norvegicus)
REACT:R-HSA-2255342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RALA exchanges GDP for GTP (Homo sapiens)
REACT:R-SSC-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Sus scrofa)
REACT:R-SSC-425822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Sus scrofa)
REACT:R-HSA-450222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
REACT:R-RNO-193695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK interacts with TRAF6 (Rattus norvegicus)
REACT:R-SSC-76496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Sus scrofa)
RHEA:67591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)
RHEA:47252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0001165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase I cis-regulatory region sequence-specific DNA binding
GO:0001165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase I upstream element sequence-specific DNA binding
GO:0001165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase I upstream control element sequence-specific DNA binding
GO:0001165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase I enhancer sequence-specific DNA binding
REACT:R-CFA-5654664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS binds GRB2:SOS1 (Canis familiaris)
REACT:R-HSA-77254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Homo sapiens)
REACT:R-HSA-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Homo sapiens)
REACT:R-SSC-417896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y6 receptor can bind to UDP (Sus scrofa)
RHEA:30629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate + H(+) + NADH => (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+)
RHEA:10610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)
RHEA:40126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Dictyostelium discoideum)
REACT:R-BTA-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Bos taurus)
REACT:R-HSA-9636375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SecA2 transports SapM from cytoplasm to cytosol (Homo sapiens)
RHEA:11558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnitine + H(+) + NADH => (S)-carnitine + NAD(+)
RHEA:49630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine
REACT:R-HSA-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Homo sapiens)
GO:0046029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MTD activity
GO:0046029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannitol dehydrogenase activity
GO:0046029	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannitol:NAD+ 1-oxidoreductase activity
GO:0046029	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD-dependent mannitol dehydrogenase activity
REACT:R-RNO-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Rattus norvegicus)
RHEA:58936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH = all-trans-lycopaoctaene + 2 diphosphate + NAD(+)
REACT:R-MMU-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Mus musculus)
RHEA:40083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:47654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + ribitol => D-ribitol 1-phosphate + H2O
REACT:R-DRE-4167509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial BTD hydrolyses BCTN (Danio rerio)
REACT:R-DRE-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)
REACT:R-DRE-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Danio rerio)
REACT:R-HSA-2028679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Homo sapiens)
REACT:R-HSA-192841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral Protein Synthesis (Homo sapiens)
RHEA:55550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine
GO:0044682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)-dependent archaeal-specific GTP cyclohydrolase activity
GO:0044682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaeal-specific GTP cyclohydrolase activity
GO:0044682	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MptA activity
REACT:R-DDI-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Dictyostelium discoideum)
REACT:R-DME-432428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic CRY is degraded by the 26S proteasome (Drosophila melanogaster)
REACT:R-BTA-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Bos taurus)
GO:0140843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity
REACT:R-CFA-5634103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 dissociates from atRA:RAR:RXR (Canis familiaris)
GO:0034919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyryl-CoA 2-C-propionyltransferase activity
REACT:R-HSA-9621242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
RHEA:20113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate
RHEA:20113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-phosphoglucomutase"
RHEA:20113	skos:prefLabel	"beta-phosphoglucomutase"
RHEA:65795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:32722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:27413	skos:prefLabel	"codeine 3-O-demethylase"
RHEA:27413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + codeine + O2 = CO2 + formaldehyde + morphine + succinate
RHEA:27413	skos:altLabel	"codeine O-demethylase"
RHEA:27413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"codeine 3-O-demethylase"
REACT:R-HSA-6786058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL4-bound IL4R1 (Homo sapiens)
RHEA:45303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine + H2O <=> an N-acyl-sphingoid base + H(+) + phosphocholine
REACT:R-HSA-264758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Homo sapiens)
REACT:R-DME-6804762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 forms homotetramers (Drosophila melanogaster)
RHEA:41638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depolarization-activated voltage gated calcium channel activity
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	depolarization-activated calcium channel
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage gated calcium channel activity
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Homo sapiens)
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depolarization-activated voltage-gated calcium channel activity
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dihydropyridine-sensitive calcium channel activity
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium ion channel activity
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depolarization-activated voltage-gated calcium channel
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-sensitive calcium channel
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity
GO:0005245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent calcium channel activity
REACT:R-SCE-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Saccharomyces cerevisiae)
REACT:R-DRE-205319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of APS and p-KIT (Danio rerio)
RHEA:24908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + NH4(+) => L-tyrosine
REACT:R-DRE-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Danio rerio)
REACT:R-MMU-2028294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Mus musculus)
REACT:R-RNO-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Rattus norvegicus)
REACT:R-RNO-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Rattus norvegicus)
RHEA:38040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DME-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Drosophila melanogaster)
RHEA:44774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2
RHEA:14556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate <=> 2-oxoglutarate + cephalosporin C
GO:0033418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUC codon-amino acid adaptor activity
GO:0033418	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine tRNA
GO:0033418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTC codon-amino acid adaptor activity
REACT:R-RNO-9027607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Rattus norvegicus)
REACT:R-DME-8941618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)
RHEA:32506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0039556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDA5 binding
GO:0039556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDA-5 binding
REACT:R-CEL-2032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ), TBX5, and PCAF form a complex (Caenorhabditis elegans)
RHEA:20541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 = 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)
REACT:R-DME-5661240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCXR tetramer reduces L-xylulose to xylitol (Drosophila melanogaster)
REACT:R-SSC-549241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Sus scrofa)
RHEA:50022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+) => decanoyl-CoA + H2O
REACT:R-RNO-5649854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to oxidatively damaged AP site (Rattus norvegicus)
RHEA:39169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetradecanoyl-CoA
GO:0036461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLOC-2 complex binding
REACT:R-XTR-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Xenopus tropicalis)
REACT:R-BTA-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Bos taurus)
REACT:R-XTR-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)
GO:0004984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	olfactory receptor activity
GO:0004984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant receptor activity
REACT:R-HSA-6790905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA (Homo sapiens)
RHEA:41356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranylgeranyl-bacteriochlorophyllide a reductase"
RHEA:41356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacteriochlorophyll a + 3 NADP(+) = geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH
RHEA:41356	skos:prefLabel	"geranylgeranyl-bacteriochlorophyllide a reductase"
RHEA:31137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate
REACT:R-MMU-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Mus musculus)
REACT:R-CFA-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Canis familiaris)
RHEA:45725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl alcohol + NADP(+) => (E)-4-coumaraldehyde + H(+) + NADPH
REACT:R-HSA-9634886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds RBFOX3 (NeuN) gene promoter (Homo sapiens)
REACT:R-DRE-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Danio rerio)
RHEA:18866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA => (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA
RHEA:53092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine
RHEA:46708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] = AMP + H(+) + salicyl-[non-ribosomal peptide synthase]
REACT:R-BTA-8878220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the NOTCH1 coactivator complex (Bos taurus)
RHEA:31709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CFA-159001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)
RHEA:49121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + protoviolaceinate => H2O + NADP(+) + violaceinate
REACT:R-SSC-392054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Sus scrofa)
REACT:R-DRE-1013013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of GABA B receptor with G protein beta-gamma subunits (Danio rerio)
RHEA:68220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol = (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA
RHEA:69374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxohexanoate + H2O2 => 2-hydroxyhexanoate + O2
REACT:R-BTA-6810464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT14 hydrolyses UDP-Glc to G1P and UMP (Bos taurus)
RHEA:69320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucoerucin + H2O = (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose
RHEA:69097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-kynurenine => H2O + kynurenate + L-methionine
RHEA:28247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + ATP => (R)-4-phosphopantoate + ADP + H(+)
GO:0016218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyketide synthase activity
GO:0016218	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PKS activity
RHEA:20328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-4-acetylaminobiphenyl <=> N-acetoxy-4-aminobiphenyl
RHEA:67405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Drosophila melanogaster)
RHEA:70744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-5323526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRAT proteins bind GSK3beta (Canis familiaris)
REACT:R-HSA-180540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of APOBEC3G (Homo sapiens)
REACT:R-CFA-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Canis familiaris)
RHEA:49100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester
REACT:R-CEL-1793209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses Chondroitin chains (Caenorhabditis elegans)
RHEA:55397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + H(+) + NADH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine
REACT:R-HSA-398188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC beta is activated by G alpha (q) (Homo sapiens)
RHEA:52752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isomaltose = beta-D-glucose + D-glucose
RHEA:52752	skos:prefLabel	"isomaltose glucohydrolase"
RHEA:52752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isomaltose glucohydrolase"
REACT:R-HSA-428515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SOS to plasma membrane (Homo sapiens)
REACT:R-RNO-6786050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Rattus norvegicus)
REACT:R-HSA-6782004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the pre-incision complex in TC-NER (Homo sapiens)
REACT:R-HSA-964811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5AR2 binds anaphylatoxins and thier desArginated derivatives (Homo sapiens)
REACT:R-HSA-9749464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the IKBIP gene promoter (Homo sapiens)
REACT:R-SSC-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Sus scrofa)
REACT:R-SSC-2129375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin cross-linking by lysyl oxidase (Sus scrofa)
REACT:R-SSC-9701485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds JAK3 (Sus scrofa)
GO:0017077	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uncoupling protein activity
GO:0017077	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial uncoupling protein activity
GO:0017077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidative phosphorylation uncoupler activity
REACT:R-DDI-9020270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Dictyostelium discoideum)
REACT:R-HSA-1839100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions (Homo sapiens)
REACT:R-CFA-9708557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 binds BACH1:MAFK (Canis familiaris)
REACT:R-SSC-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Sus scrofa)
REACT:R-HSA-159443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Homo sapiens)
REACT:R-RNO-9008258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 binds ESR1:estrogen:TFGA gene (Rattus norvegicus)
REACT:R-SSC-5218640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates p-Y397-PTK2 (Sus scrofa)
RHEA:62466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O
REACT:R-MMU-77277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Mus musculus)
GO:0140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serine phosphatase activity (H2-S140 specific)
GO:0140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2-S140 serine phosphatase activity
GO:0140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2S140 phosphatase activity
RHEA:14058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a glycerophospholipid => a monoacylglycerophospholipid + a triacyl-sn-glycerol
RHEA:10801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + XMP => 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
REACT:R-CFA-5654701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
REACT:R-MMU-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Mus musculus)
REACT:R-BTA-5668520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26Sproteasome degrades K48polyUb-NIK (Bos taurus)
REACT:R-RNO-549129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations into hepatic cells (Rattus norvegicus)
REACT:R-CFA-5578966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A:AGO2:miRNA is transported into the nucleus (Canis familiaris)
RHEA:22940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginine kinase"
RHEA:22940	skos:altLabel	"arginine phosphokinase"
RHEA:22940	skos:prefLabel	"arginine kinase"
RHEA:22940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginine = ADP + H(+) + N(omega)-phospho-L-arginine
RHEA:70910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)
RHEA:65336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrodrimanin T + H(+) + NADPH + O2 = chrodrimanin A + H2O + NADP(+)
RHEA:44568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) = 2-all-trans-hexaprenylphenol + CO2
REACT:R-DME-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Drosophila melanogaster)
REACT:R-DRE-5693153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1K dephosphorylates p-BCKDH (Danio rerio)
REACT:R-SPO-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)
REACT:R-GGA-4793925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S303,307-HSF1 binds YWHAE (14-3-3) (Gallus gallus)
RHEA:16191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + homogentisate => 3-(4-hydroxyphenyl)pyruvate + O2
REACT:R-XTR-1564164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type V degradation by MMP2,9,10 (Xenopus tropicalis)
REACT:R-CFA-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Canis familiaris)
REACT:R-HSA-452353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of EOMES in the primitive streak (Homo sapiens)
REACT:R-BTA-5661115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Bos taurus)
REACT:R-MMU-141156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL-mediated dimerization of procaspase-8 (Mus musculus)
REACT:R-DRE-5685605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF7 binds SLAMF7 (Danio rerio)
REACT:R-GGA-2473184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follistatin (FST) binds Activin (Gallus gallus)
REACT:R-SSC-446694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 phosphorylates IRAK1 (Sus scrofa)
RHEA:56935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH
RHEA:37214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-GMP + H2O <=> guanosine 2'-monophosphate + H(+)
EC:3.6.3.-	skos:prefLabel	"Acting on acid anhydrides; catalyzing transmembrane movement of substances"
EC:3.6.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on acid anhydrides; catalyzing transmembrane movement of substances"
GO:0051800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Homo sapiens)
GO:0051800	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PTEN activity
GO:0051800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Homo sapiens)
GO:0051800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
REACT:R-GGA-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Gallus gallus)
REACT:R-HSA-1112708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-Y759-IL6ST (Homo sapiens)
RHEA:46792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-5666160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates DIAPH2-2 at kinetochores (Canis familiaris)
REACT:R-GGA-5661217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds zinc (Gallus gallus)
REACT:R-BTA-1250220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of ERBB4 (Bos taurus)
REACT:R-MMU-209536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkB is ubiquitinated and degraded (Mus musculus)
REACT:R-HSA-8938073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Homo sapiens)
RHEA:18023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GD1a (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E))
RHEA:39970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobut-2-enoate <=> 2-iminobutanoate
RHEA:70725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sitosterol(in) => sitosterol(out)
REACT:R-HSA-1112609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter (Homo sapiens)
REACT:R-BTA-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)
REACT:R-BTA-8851954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GAB1 recruits PI3K to MET (Bos taurus)
REACT:R-DRE-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Danio rerio)
RHEA:71065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-histidine(in) => L-arginine(in) + L-histidine(out)
REACT:R-GGA-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Gallus gallus)
RHEA:54578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in tRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2
RHEA:26362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + NADPH + S-adenosyl-L-methionine => 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)
RHEA:10130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-neoxanthin => all-trans-violaxanthin
RHEA:45810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-dihydroxy-5-oxohexanedioate + H2O => galactarate
RHEA:58382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + nonanal => NADP(+) + nonan-1-ol
RHEA:65815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 <=> A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA
REACT:R-DRE-1472121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of p-KIT on Y900 by Src kinases (Danio rerio)
REACT:R-MMU-9021609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR-associated SRC autophosphorylates (Mus musculus)
EC:1.5.3.16	skos:altLabel	"SMO"
EC:1.5.3.16	skos:prefLabel	"spermine oxidase"
EC:1.5.3.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spermine oxidase"
REACT:R-HSA-8848005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)
REACT:R-HSA-8871260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD2 (Homo sapiens)
REACT:R-HSA-9029566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Homo sapiens)
RHEA:52688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH
RHEA:16754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 => 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)
RHEA:23212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyl-beta-alanine deacetylase"
RHEA:23212	skos:prefLabel	"N-acetyl-beta-alanine deacetylase"
RHEA:23212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-alanine = acetate + beta-alanine
RHEA:57985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP
REACT:R-HSA-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Homo sapiens)
RHEA:23797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-O-acetylnorajmaline + H2O => acetate + H(+) + norajmaline
REACT:R-BTA-8855825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTRA1 hydrolyzes ACAN (Aggrecan) (Bos taurus)
REACT:R-SSC-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Sus scrofa)
REACT:R-SSC-381503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP6 binds IGF forming IGF:IGFBP6 (Sus scrofa)
REACT:R-SSC-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Sus scrofa)
REACT:R-DME-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Drosophila melanogaster)
RHEA:61029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	itaconate + L-cysteinyl-[protein] => S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]
RHEA:41135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-RNO-1470009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs (Rattus norvegicus)
REACT:R-HSA-5693001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8,8B acetylate BACE1 (Homo sapiens)
RHEA:30661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-threonine + phosphate => 4-(phosphooxy)-L-threonine + H2O
REACT:R-HSA-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Homo sapiens)
RHEA:26177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)
REACT:R-SPO-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Schizosaccharomyces pombe)
REACT:R-SPO-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Schizosaccharomyces pombe)
RHEA:18196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate
RHEA:55950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + NH4(+) + pyruvate => A + D-alanine + H2O
RHEA:61871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate
REACT:R-CFA-177925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)
REACT:R-SSC-110353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MBD4 glycosylase by APEX1 at the AP site (Sus scrofa)
REACT:R-RNO-6805022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 binds the heterodimer of MDM2 and MDM4 (Rattus norvegicus)
REACT:R-CEL-3323013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)
RHEA:68370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP => 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose
REACT:R-SSC-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Sus scrofa)
RHEA:42449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutaryl-CoA => (2E)-glutaconyl-CoA + H2O
REACT:R-CFA-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Canis familiaris)
RHEA:31977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxusin
RHEA:17776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-cysteine + tRNA(Cys) <=> AMP + diphosphate + L-cysteinyl-tRNA(Cys)
REACT:R-SSC-1470009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STATs (Sus scrofa)
RHEA:50885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O => (9Z-octadecenoyl)-glycerol + phosphate
REACT:R-HSA-9654523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP bind PDE6D on KRAS4B (Homo sapiens)
REACT:R-GGA-5654658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS bind to PPTN11 (Gallus gallus)
REACT:R-RNO-9707977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Rattus norvegicus)
RHEA:12653	skos:altLabel	"Malic enzyme"
RHEA:12653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NAD(+) = CO2 + NADH + pyruvate
RHEA:12653	skos:prefLabel	"malate dehydrogenase (decarboxylating)"
RHEA:12653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malate dehydrogenase (decarboxylating)"
RHEA:12653	skos:altLabel	"NAD-malic enzyme"
RHEA:12653	skos:altLabel	"pyruvic-malic carboxylase"
REACT:R-SSC-174587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Sus scrofa)
RHEA:55968	skos:prefLabel	"(+)-O-methylkolavelool synthase"
RHEA:55968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-O-methylkolavelool synthase"
RHEA:55968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-kolavelool + S-adenosyl-L-methionine = (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine
RHEA:32991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-BTA-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Bos taurus)
RHEA:37492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine
RHEA:39491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)
REACT:R-DME-9614423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO1 (Drosophila melanogaster)
RHEA:51387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + serotonin <=> CoA + H(+) + N-hexadecanoyl-serotonin
RHEA:57448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-tyrosine + tRNA(Tyr) = AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)
REACT:R-CFA-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Canis familiaris)
RHEA:13362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + sn-glycerol 3-phosphate => CDP-glycerol + diphosphate
REACT:R-GGA-199154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD200 binds to CD200R (Gallus gallus)
RHEA:60960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP
REACT:R-RNO-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
REACT:R-HSA-6791327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the BCL2L14 gene (Homo sapiens)
REACT:R-XTR-1861595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extension of pseudopodia by myosin-X in a PI3K dependent manner (Xenopus tropicalis)
RHEA:64054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine => (13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine
RHEA:39505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH
REACT:R-DRE-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Danio rerio)
REACT:R-XTR-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Xenopus tropicalis)
RHEA:16773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ganglioside galactosyltransferase"
RHEA:16773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GM1 (d18:1(4E)) + H(+) + UDP
RHEA:16773	skos:prefLabel	"ganglioside galactosyltransferase"
REACT:R-HSA-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Homo sapiens)
REACT:R-DME-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Drosophila melanogaster)
REACT:R-GGA-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Gallus gallus)
REACT:R-MMU-5683888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMCD1 binds GATA6, sequestering it (Mus musculus)
REACT:R-BTA-202718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Bos taurus)
RHEA:24065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5-aminolevulinate => H(+) + 2 H2O + porphobilinogen
REACT:R-HSA-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Homo sapiens)
REACT:R-BTA-9012556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Bos taurus)
RHEA:66888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-4088024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Homo sapiens)
RHEA:19982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + S-(hydroxymethyl)glutathione => H(+) + NADPH + S-formylglutathione
REACT:R-GGA-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Gallus gallus)
RHEA:23864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP
RHEA:23864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase"
RHEA:23864	skos:prefLabel	"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase"
RHEA:23864	skos:altLabel	"MECDP-synthase"
REACT:R-HSA-9710106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE cleaves GSDMD (Homo sapiens)
REACT:R-CFA-162742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Canis familiaris)
RHEA:65917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + pyruvate => H2O + kynurenate + L-alanine
RHEA:37701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA
REACT:R-DDI-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Dictyostelium discoideum)
RHEA:53170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-BTA-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Bos taurus)
RHEA:57097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + A + methanethiol
REACT:R-SCE-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Saccharomyces cerevisiae)
REACT:R-HSA-8858498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SL (surrogate light chain) binds IgH to form pre-BCR (Homo sapiens)
RHEA:34687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + N-acyl-15-methylhexadecasphinganine + O2 = A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine
RHEA:27367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromomethane + S-adenosyl-L-homocysteine => bromide + S-adenosyl-L-methionine
RHEA:13767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + chloride + formaldehyde + 2 H(+) => bromochloromethane + H2O
GO:0062062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligosaccharyltransferase complex binding
RHEA:56510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate
RHEA:63064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + tetraacetate lactone
RHEA:43296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate
REACT:R-GGA-417908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY1 binds ADP (Gallus gallus)
RHEA:12807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcanadine + S-adenosyl-L-homocysteine => (S)-canadine + S-adenosyl-L-methionine
REACT:R-MMU-3640844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 binds RibC-AXIN:TNKS complex (Mus musculus)
REACT:R-CFA-879930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 is recruited by JAK2 (Canis familiaris)
REACT:R-RNO-2161948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Rattus norvegicus)
REACT:R-XTR-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Xenopus tropicalis)
RHEA:27884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-CMP + H(+) => 2',3'-cyclophospho-CMP + H2O
REACT:R-HSA-9630792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p16INK4A mutants do not bind CDK4 (Homo sapiens)
REACT:R-DDI-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Dictyostelium discoideum)
REACT:R-CEL-429798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Caenorhabditis elegans)
REACT:R-HSA-1168767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylates STAT1/STAT3 (Homo sapiens)
GO:0047562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity
GO:0047562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity
GO:0047562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythro-beta-hydroxyaspartate aldolase activity
GO:0047562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyaspartate aldolase activity
GO:0047562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythro-beta-hydroxyaspartate glycine-lyase activity
GO:0047562	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)
RHEA:60691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADH
REACT:R-BTA-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)
REACT:R-RNO-1602368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Rattus norvegicus)
RHEA:27299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formylbenzoate + H2O + NAD(+) => 2 H(+) + NADH + phthalate
REACT:R-HSA-8853792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET tyrosine phosphorylation (Homo sapiens)
RHEA:61564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tetracycline + H(+) + NADPH + O2 = a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)
REACT:R-DRE-6788999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HV1-mediated H+ transfer (Danio rerio)
RHEA:52333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] => 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]
REACT:R-BTA-2028644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Bos taurus)
REACT:R-RNO-5696213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to methylarsonite (Rattus norvegicus)
GO:0043785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FldA
GO:0043785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinnamoyl-CoA:phenyllactate CoA-transferase activity
GO:0043785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity
REACT:R-SSC-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Sus scrofa)
REACT:R-CFA-8942607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Canis familiaris)
RHEA:49562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate => D-sedoheptulose 7-phosphate
REACT:R-DRE-9021050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 oligomer binds ESRs (Danio rerio)
REACT:R-BTA-9021072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC7, ZDHHC21 palmitoylate ESR1 (Bos taurus)
REACT:R-CFA-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Canis familiaris)
RHEA:65968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate
RHEA:55454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:45297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingosylphosphocholine + H2O => a sphingoid base + H(+) + phosphocholine
REACT:R-SSC-5696146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC2 deaminates TYR (Sus scrofa)
GO:0003859	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	enoyl coenzyme A hydrase (D)
GO:0003859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	crotonase activity
GO:0003859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)
GO:0003859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity
GO:0003859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutyryl-CoA dehydratase activity
GO:0003859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-hydroxybutyryl-CoA dehydratase activity
GO:0003859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-hydroxybutyryl coenzyme A dehydratase activity
REACT:R-HSA-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Homo sapiens)
RHEA:62779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-MMU-5654159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds PLCG1 (Mus musculus)
RHEA:36683	skos:prefLabel	"protein S-acyltransferase"
RHEA:36683	skos:altLabel	"DHHC palmitoyl transferase"
RHEA:36683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]
RHEA:36683	skos:altLabel	"S-protein acyltransferase"
RHEA:36683	skos:altLabel	"G-protein palmitoyltransferase"
RHEA:36683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein S-acyltransferase"
GO:0140892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium,bicarbonate:chloride antiporter activity
GO:0140892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-dependent chloride/bicarbonate exchanger activity
GO:0052860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineic-acid 3-dioxygenase activity
GO:0052860	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
RHEA:69695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menadione + NADH = menadiol + NAD(+)
RHEA:41977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) => CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)
REACT:R-DME-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Drosophila melanogaster)
REACT:R-SSC-1482868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Sus scrofa)
RHEA:31659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine
REACT:R-MMU-9013284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3-ligand complex is cleaved to produce NEXT3 (Mus musculus)
GO:0004861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclin-dependent kinase inhibitor
GO:0004861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0004861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin dependent protein kinase inhibitor activity
GO:0004861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
GO:0004861	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cyclin-dependent protein kinase inhibitor activity
GO:0004861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDK inhibitor
GO:0004861	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclin dependent kinase inhibitor
GO:0004861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
REACT:R-SSC-5696183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC3 deaminates BZAM (Sus scrofa)
RHEA:51934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c3] + thiosulfate => 2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite
REACT:R-HSA-9686521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2:CCNA phosphorylates TERF2 (Homo sapiens)
REACT:R-DRE-9015122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors bind Va:Xa (Danio rerio)
REACT:R-RNO-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Rattus norvegicus)
RHEA:52889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-phenylhydroxylamine + NADP(+) => H(+) + NADPH + nitrosobenzene
REACT:R-SSC-6806831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5Rs reduce MetHb to HbA (Sus scrofa)
RHEA:54022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein] => L-lysyl-[protein] + propanoyl-CoA
REACT:R-DRE-157849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes containing mRNA that does not circularize (Danio rerio)
REACT:R-CEL-77593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage and polyadenylation of Intronless Pre-mRNA (Caenorhabditis elegans)
REACT:R-GGA-3266557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I cleaves iC3b (Gallus gallus)
RHEA:39447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)
RHEA:26267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroabietate + 2 H(+) + NADPH => dehydroabietadienal + H2O + NADP(+)
RHEA:69418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypothiocyanous acid => H(+) + H2O2 + thiocyanate
REACT:R-MMU-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Mus musculus)
REACT:R-XTR-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Xenopus tropicalis)
REACT:R-DDI-8952044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Dictyostelium discoideum)
REACT:R-BTA-2730886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC by SYK kinase (Bos taurus)
REACT:R-CFA-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Canis familiaris)
REACT:R-CEL-2065550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds Importin beta-1 (Caenorhabditis elegans)
GO:0031172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine N5-monooxygenase activity
GO:0031172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine 5-monooxygenase activity
REACT:R-HSA-4085217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Homo sapiens)
REACT:R-GGA-8936621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)
REACT:R-XTR-392295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma recruits PI3K gamma (Xenopus tropicalis)
GO:0080106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylthiopropyl glucosinolate S-oxygenase activity
REACT:R-XTR-6782820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates SUDS3 (Xenopus tropicalis)
REACT:R-RNO-74885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCYs converts GTP to cGMP (Rattus norvegicus)
REACT:R-DME-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
RHEA:21516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopiperitenone Delta-isomerase"
RHEA:21516	skos:prefLabel	"isopiperitenone Delta-isomerase"
RHEA:21516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopiperitenone = piperitenone
REACT:R-MMU-5668543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3:NIK binds TRAF2:cIAP1/2 (Mus musculus)
REACT:R-RNO-9645394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Rattus norvegicus)
RHEA:64484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA = 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA
REACT:R-RNO-204773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb7 (Rattus norvegicus)
RHEA:38995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:35394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA
RHEA:65358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP
REACT:R-HSA-3858482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is recruited to the receptor (Homo sapiens)
GO:0016508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain enoyl coenzyme A hydratase activity
GO:0016508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity
GO:0016508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-enoyl-CoA hydratase activity
RHEA:58658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine
REACT:R-GGA-984648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Gallus gallus)
REACT:R-DME-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Drosophila melanogaster)
RHEA:10422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + sulfoacetaldehyde => pyruvate + taurine
REACT:R-CFA-139918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BIM by JNK (Canis familiaris)
RHEA:25370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) <=> H(+) + momilactone A + NADPH
REACT:R-GGA-432164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Gallus gallus)
REACT:R-DRE-374173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR1 (Danio rerio)
RHEA:14085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA = 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate
REACT:R-RNO-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Rattus norvegicus)
RHEA:28796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH
RHEA:33218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 3 diphosphate
REACT:R-XTR-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Xenopus tropicalis)
RHEA:44325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-butyrylglycerol + H2O => butanoate + glycerol + H(+)
REACT:R-GGA-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Gallus gallus)
REACT:R-CFA-451311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca-permeable Kainate receptors (Canis familiaris)
REACT:R-DDI-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Dictyostelium discoideum)
REACT:R-GGA-5159250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF7IP binds SETDB1 (Gallus gallus)
RHEA:66342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O
RHEA:61189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP
GO:0008840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-tetrahydrodipicolinate synthase activity
GO:0008840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)
GO:0008840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrodipicolinate synthetase activity
GO:0008840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHDPS activity
GO:0008840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrodipicolinate synthase activity
GO:0008840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]
GO:0008840	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrodipicolinic acid synthase activity
REACT:R-BTA-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Bos taurus)
REACT:R-CFA-1168635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (PKC-beta) phosphorylates CARMA1 (Canis familiaris)
RHEA:60401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine
RHEA:44798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-13 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-13 + S-adenosyl-L-methionine
RHEA:33714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulfomuconolactone + H2O <=> 2 H(+) + maleylacetate + sulfite
REACT:R-BTA-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Bos taurus)
REACT:R-RNO-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Rattus norvegicus)
REACT:R-RNO-5610742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI1 (Rattus norvegicus)
REACT:R-HSA-9674816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)
REACT:R-GGA-430021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAN2-PAN3 complex partially deadenylates mRNA (Gallus gallus)
REACT:R-BTA-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Bos taurus)
REACT:R-HSA-8850560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha releases G-protein heterotrimer from PDCL  (Homo sapiens)
REACT:R-SSC-9706308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRB10 (Sus scrofa)
RHEA:71033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(out) + L-phenylalanine(in) => L-cysteine(in) + L-phenylalanine(out)
RHEA:16154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic amine + H2O + O2 => an aldehyde + H2O2 + NH4(+)
REACT:R-HSA-9769042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 stimulates IQSEC3 gene expression (Homo sapiens)
RHEA:58326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol
REACT:R-DME-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Drosophila melanogaster)
REACT:R-DRE-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Danio rerio)
REACT:R-DME-5624492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK phosphorylates p21 RAF1 on S338 (Drosophila melanogaster)
REACT:R-MMU-420586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Necl-2 trans heterodimer interaction (Mus musculus)
REACT:R-MMU-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Mus musculus)
REACT:R-RNO-176669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Rattus norvegicus)
REACT:R-CFA-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Canis familiaris)
REACT:R-SSC-6804383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 methylates TP53 (Sus scrofa)
REACT:R-BTA-8851859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds RANBP9 and SOS1 (Bos taurus)
RHEA:41999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP
REACT:R-XTR-5682588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 binds phosphorylated MDC1 at DNA DSBs (Xenopus tropicalis)
RHEA:53204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-912757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)
REACT:R-RNO-3371360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)
REACT:R-HSA-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
REACT:R-DRE-8877308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MADD exchanges GTP for GDP on RAB27 (Danio rerio)
REACT:R-RNO-112266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Rattus norvegicus)
REACT:R-BTA-2022919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Bos taurus)
GO:0032452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity
RHEA:33019	skos:prefLabel	"beta-lysine N(6)-acetyltransferase"
RHEA:33019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-lysine N(6)-acetyltransferase"
RHEA:33019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3,6-diaminohexanoate + acetyl-CoA = (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)
RHEA:11671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate
RHEA:69040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 = 2-nitrobutanedioate + H2O + NADP(+)
GO:0102890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naringenin chalcone 4'-O-glucosyltransferase activity
REACT:R-DRE-200326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CK octamer] (Danio rerio)
REACT:R-CFA-162729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Canis familiaris)
REACT:R-HSA-2161662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Homo sapiens)
RHEA:49742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + deoxyviolacein + 2 H2O + NADP(+) => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate
RHEA:37973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + octadecanoyl-CoA
GO:0015042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trypanothione-disulfide reductase activity
GO:0015042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trypanothione:NADP+ oxidoreductase activity
GO:0015042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:trypanothione oxidoreductase activity
GO:0015042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trypanothione-disulphide reductase activity
GO:0015042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N1,N8-bis(glutathionyl)spermidine reductase activity
GO:0015042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trypanothione reductase activity
GO:0015042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(1),N(8)-bis(glutathionyl)spermidine reductase activity
RHEA:41633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine
REACT:R-SSC-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Sus scrofa)
RHEA:63844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + cumene hydroperoxide = 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O
REACT:R-SSC-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)
REACT:R-RNO-1981128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Rattus norvegicus)
REACT:R-RNO-9017797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds YBX1 (Rattus norvegicus)
REACT:R-MMU-2213017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF3 (Mus musculus)
RHEA:12615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide + 2 L-cysteine => 2 glutathione + L-cystine
REACT:R-DRE-388900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurotensin receptors can bind neurotensins (Danio rerio)
REACT:R-CFA-8849882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-4 bind reticulon 3 (Canis familiaris)
REACT:R-SPO-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)
RHEA:58833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-CEL-390252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Caenorhabditis elegans)
REACT:R-SPO-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Schizosaccharomyces pombe)
REACT:R-HSA-9026907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT hydrolyses PCTR2 to PCTR3 (Homo sapiens)
RHEA:63947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + sphinga-4E,14Z-dienine <=> an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)
REACT:R-BTA-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Bos taurus)
RHEA:72509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + prostaglandin F2alpha(in) => 2-oxoglutarate(in) + prostaglandin F2alpha(out)
RHEA:38496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + H2O => a 1,3-diacylglycerol + a fatty acid + H(+)
REACT:R-MMU-8866283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBB recruits GPCRs into clathrin-coated pits (Mus musculus)
REACT:R-MMU-9632412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 is recruited to methylated ESR1 (Mus musculus)
RHEA:27620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate => (2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate
REACT:R-SSC-1675795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Sus scrofa)
REACT:R-DDI-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Dictyostelium discoideum)
REACT:R-RNO-8851018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A1 binds DC-SIGN (Rattus norvegicus)
REACT:R-XTR-8937631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Xenopus tropicalis)
REACT:R-CEL-975389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Caenorhabditis elegans)
RHEA:17500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formononetin + UDP-alpha-D-glucose <=> ononin + UDP
RHEA:58830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9R,10R-dihydroxyoctadecanoate => (9S,10R)-epoxy-octadecanoate + H2O
RHEA:68047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)
RHEA:69448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = delta-cadinol + diphosphate
REACT:R-SSC-5625849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM1A binds KLK2 and KLK3 promoters (Sus scrofa)
REACT:R-DME-203613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylation of eNOS (Drosophila melanogaster)
REACT:R-BTA-9008587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37, IL37(?-218) binds IL18BP (Bos taurus)
RHEA:48299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin E2 1-glyceryl ester <=> glycerol + H(+) + prostaglandin E2
REACT:R-RNO-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Rattus norvegicus)
REACT:R-BTA-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Bos taurus)
RHEA:65437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate
GO:0047467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetaldehyde-oxime isomerase activity
GO:0097265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5(S)-HETE dehydrogenase activity
GO:0097265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HETE is oxidised to 5-oxoETE by 5-HEDH (Homo sapiens)
GO:0097265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity
GO:0097265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HETE dehydrogenase activity
GO:0097265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-eicosatetraenoic acid dehydrogenase activity
REACT:R-DRE-5692768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates KALRN (Danio rerio)
REACT:R-HSA-8849348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Homo sapiens)
RHEA:11791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate + NAD(+) <=> H(+) + NADH + NH4(+) + oxaloacetate
RHEA:32432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-menthone + H(+) + NADPH + O2 => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)
RHEA:53670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate => (2E,6E)-farnesyl diphosphate
EC:1.14.11.n4	skos:prefLabel	"ankyrin-repeat-histidine dioxagenase"
EC:1.14.11.n4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ankyrin-repeat-histidine dioxagenase"
REACT:R-RNO-1168640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated IkB is degraded (Rattus norvegicus)
REACT:R-SSC-5688834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds VCP (Sus scrofa)
REACT:R-DRE-6782141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)
RHEA:17947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-9621410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR gene expression (Homo sapiens)
RHEA:57691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[corrinoid adenosyltransferase] + cob(II)inamide <=> cob(II)inamide-[corrinoid adenosyltransferase]
RHEA:71107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(out) + S-methylmercury-L-cysteine(in) = L-leucine(in) + S-methylmercury-L-cysteine(out)
GO:0019191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellobiose permease activity
GO:0019191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellobiose transmembrane transporter activity
RHEA:14675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a polar amino acid(in) + ADP + H(+) + phosphate => a polar amino acid(out) + ATP + H2O
RHEA:71225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + 2 Na(+)(in) + taurine(in) => chloride(out) + 2 Na(+)(out) + taurine(out)
REACT:R-RNO-3371467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates HSF1 (Rattus norvegicus)
REACT:R-DME-2855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (parenchymal cell) (Drosophila melanogaster)
RHEA:48681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) => a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH
REACT:R-HSA-6807027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)
RHEA:31506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate <=> 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate
RHEA:44496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine = 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine
GO:0016702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
REACT:R-MMU-981814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC2 transfers sialic acid to Core 1 mucins (Mus musculus)
RHEA:72378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(out) + iodide(in) <=> hydrogencarbonate(in) + iodide(out)
REACT:R-CFA-3000319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BORA binds PLK1 and AURKA (Canis familiaris)
RHEA:51519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + S-adenosyl-L-methionine <=> (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine
RHEA:14034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-1D-myo-inositol => 1D-myo-inositol 1-phosphate + glycerol + H(+)
RHEA:52431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-leukotriene B4 + H(+) + NADH <=> 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)
RHEA:72797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin-bisglucuronoside(in) => bilirubin-bisglucuronoside(out)
RHEA:14709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid
REACT:R-HSA-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Homo sapiens)
RHEA:52992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine = [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine
REACT:R-RNO-380272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plk1-mediated phosphorylation of Nlp (Rattus norvegicus)
RHEA:33288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + spermidine => 1-pyrroline + AH2 + propane-1,3-diamine
REACT:R-CEL-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Caenorhabditis elegans)
REACT:R-HSA-170861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimeric TGF-beta-1 binds to the receptor (Homo sapiens)
EC:1.14.13.245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"assimilatory dimethylsulfide S-monooxygenase"
EC:1.14.13.245	skos:prefLabel	"assimilatory dimethylsulfide S-monooxygenase"
REACT:R-BTA-6799959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP3,4 binds bacterial peptidoglycan (Bos taurus)
REACT:R-SPO-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Schizosaccharomyces pombe)
REACT:R-RNO-2186771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 binds SMAD7 (Rattus norvegicus)
REACT:R-CFA-6786245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNS1 transforms ATP, L-His, b-Ala to CARN (Canis familiaris)
REACT:R-SSC-2161792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Sus scrofa)
REACT:R-XTR-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Xenopus tropicalis)
REACT:R-XTR-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Xenopus tropicalis)
GO:0045439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopenicillin N epimerase activity
GO:0045439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopenicillin-N epimerase activity
GO:0045439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity
REACT:R-SPO-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)
REACT:R-PFA-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Plasmodium falciparum)
REACT:R-GGA-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Gallus gallus)
REACT:R-MMU-5205652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 recruits Parkin to the outer mitochondrial membrane. (Mus musculus)
REACT:R-DDI-5213464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is phosphorylated (Dictyostelium discoideum)
REACT:R-MTU-936631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate uptake in the cytosol (Mycobacterium tuberculosis)
REACT:R-HSA-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
RHEA:48165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxypheophorbide a + H2O => H(+) + red chlorophyll catabolite
RHEA:21454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => a [peptide]-C-terminal glycine + 2 L-ascorbate + O2
REACT:R-MMU-8951500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CANX from nonameric complex (Mus musculus)
RHEA:44824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine
RHEA:30321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theobromine
RHEA:40664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine => 2-aminoprop-2-enoate + H2O
REACT:R-DME-416985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to synapse (Drosophila melanogaster)
REACT:R-CEL-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Caenorhabditis elegans)
RHEA:28986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite(in) <=> nitrite(out)
RHEA:29450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate(in) <=> glycolate(out)
RHEA:56075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylphloroglucinol + UDP-alpha-D-glucose <=> a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP
REACT:R-HSA-844612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCARD recruits procaspase-1 via CARD (Homo sapiens)
REACT:R-BTA-5666008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCAI binds SRF:MKL1 (Bos taurus)
REACT:R-SSC-182990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty sequesters CBL away from active EGFR (Sus scrofa)
REACT:R-XTR-1604690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MMP9 intermediate form by MMPs (Xenopus tropicalis)
REACT:R-HSA-4086204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IBSP binds collagen type I (Homo sapiens)
GO:0046522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylthioribose kinase activity
GO:0046522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity
GO:0046522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thioribose kinase activity
GO:0046522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylthioribose kinase activity
GO:0046522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methylthioribose kinase (phosphorylating)
GO:0046522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity
GO:0046522	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MTR kinase activity
REACT:R-MMU-265010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Mus musculus)
REACT:R-MMU-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Mus musculus)
REACT:R-GGA-5218804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK activation by VEGFR (Gallus gallus)
RHEA:11875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]
REACT:R-HSA-9032854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2 phosphorylates CDK5 (Homo sapiens)
REACT:R-XTR-1638803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at centromeres (Xenopus tropicalis)
GO:0061503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA threonylcarbamoyladenosine dehydratase
REACT:R-SCE-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Saccharomyces cerevisiae)
RHEA:47040	skos:prefLabel	"tRNA-5-taurinomethyluridine 2-sulfurtransferase"
RHEA:47040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-5-taurinomethyluridine 2-sulfurtransferase"
RHEA:47040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] = 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]
RHEA:19128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-serine <=> 3-hydroxypyruvate + glycine
REACT:R-CFA-8875374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds LRIG1 (Canis familiaris)
REACT:R-RNO-183072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR non-clathrin mediated endocytosis (Rattus norvegicus)
RHEA:58821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonate + Na(+)(in) => acetate + CO2 + Na(+)(out)
REACT:R-BTA-444572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zinc is an agonist of GPR39 (Bos taurus)
RHEA:51352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-serine = (9Z)-octadecenoate + L-serine
RHEA:29253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + Na(+)(out) => 2 H(+)(out) + Na(+)(in)
REACT:R-DME-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Drosophila melanogaster)
REACT:R-SSC-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Sus scrofa)
REACT:R-MMU-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Mus musculus)
GO:0051377	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ethanolamine phosphate transferase activity
GO:0051377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose-ethanolamine phosphotransferase activity
GO:0051377	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphoethanolamine transferase activity
GO:0051377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Homo sapiens)
GO:0051377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EtN-P transferase activity
GO:0051377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	addition of ethanolamine phosphate to mannose of GPI precursor
REACT:R-BTA-75187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL receptor trimers bind FADD (Bos taurus)
REACT:R-MMU-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)
REACT:R-HSA-8864105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 binds ERBB2:EGFR heterodimers (Homo sapiens)
RHEA:56615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + NAD(+) <=> H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]
REACT:R-DRE-8950780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 binds p-Y693-STAT4 (Danio rerio)
RHEA:55830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-3215406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds WDR77 (Drosophila melanogaster)
REACT:R-HSA-5696357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAIR2 binds collagen (Homo sapiens)
REACT:R-RNO-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Rattus norvegicus)
RHEA:40283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + hexadecanedioyl-CoA = CoA + O-hexadecanedioyl-L-carnitine
RHEA:49104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester
REACT:R-BTA-1855153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)
RHEA:48847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
REACT:R-DDI-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Dictyostelium discoideum)
REACT:R-GGA-977250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of IRAK4 bound to activated TLR5 or 15 (Gallus gallus)
REACT:R-BTA-203680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)
RHEA:55904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloro-L-tryptophan + chloride + FADH2 + O2 = 6,7-dichloro-L-tryptophan + FAD + 2 H2O
RHEA:55904	skos:prefLabel	"7-chloro-L-tryptophan 6-halogenase"
RHEA:55904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-chloro-L-tryptophan 6-halogenase"
RHEA:54248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
RHEA:14313	skos:prefLabel	"iodophenol O-methyltransferase"
RHEA:14313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"iodophenol O-methyltransferase"
RHEA:14313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine
RHEA:16765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannitol 2-dehydrogenase (NADP(+))"
RHEA:16765	skos:altLabel	"NADP-dependent mannitol dehydrogenase"
RHEA:16765	skos:prefLabel	"mannitol 2-dehydrogenase (NADP(+))"
RHEA:16765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + NADP(+) = D-fructose + H(+) + NADPH
REACT:R-MMU-3321883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSL acetylates histone H4 (Mus musculus)
REACT:R-MMU-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Mus musculus)
RHEA:48623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
REACT:R-DME-9024334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Drosophila melanogaster)
REACT:R-GGA-6809015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Gallus gallus)
RHEA:30411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzyl alcohol O-benzoyltransferase"
RHEA:30411	skos:prefLabel	"benzyl alcohol O-benzoyltransferase"
RHEA:30411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + benzyl alcohol = benzyl benzoate + CoA
REACT:R-BTA-5218826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Bos taurus)
REACT:R-BTA-8857583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by PTK6 (Bos taurus)
RHEA:57590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-1676020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Mus musculus)
GO:0043813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
GO:0043813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity
REACT:R-BTA-8875443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates LRIG1 (Bos taurus)
GO:0016813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In linear amidines"
GO:0016813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0016813	skos:prefLabel	"In linear amidines"
REACT:R-SSC-2530445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD59 inhibits MAC formation (Sus scrofa)
RHEA:51827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + octanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)
GO:0047004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity
GO:0047004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GLcNAc dehydrogenase activity
GO:0047004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylglucosamine 6-dehydrogenase activity
GO:0047004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPacetylglucosamine dehydrogenase activity
GO:0047004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity
GO:0047004	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine dehydrogenase activity
REACT:R-MMU-8950518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Mus musculus)
REACT:R-GGA-9650165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers bind H+ (Gallus gallus)
GO:0050488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysteroid UDP-glucosyltransferase activity
GO:0050488	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity
REACT:R-GGA-2247511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2:ligand is endocytosed (Gallus gallus)
RHEA:46816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-SSC-5649854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to oxidatively damaged AP site (Sus scrofa)
REACT:R-MMU-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Mus musculus)
REACT:R-DRE-83803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Danio rerio)
REACT:R-HSA-176474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Homo sapiens)
REACT:R-BTA-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Bos taurus)
RHEA:55680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate = anthranilate + H(+) + pyruvate
REACT:R-BTA-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Bos taurus)
REACT:R-DRE-9009485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34:CSF1 binds CSF1R (Danio rerio)
REACT:R-DME-5654422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS2 (Drosophila melanogaster)
REACT:R-MMU-204873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shp2 (Mus musculus)
EC:5.3.-.-	skos:prefLabel	"Intramolecular oxidoreductases"
EC:5.3.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Intramolecular oxidoreductases"
GO:0017116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ssDNA-dependent ATPase activity
GO:0017116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ssDNA-dependent ATP-dependent DNA helicase activity
GO:0017116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded DNA-dependent ATP-dependent DNA helicase activity
GO:0017116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded DNA helicase activity
GO:0017116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded DNA-dependent ATPase activity
RHEA:35740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] => 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone
REACT:R-SSC-2465924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1LW binds 11cRAL (Sus scrofa)
RHEA:50278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2
REACT:R-GGA-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Gallus gallus)
REACT:R-MMU-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Mus musculus)
REACT:R-DRE-174374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 from MeCbl to HCYS (Danio rerio)
RHEA:17890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphoethanolamine => acetaldehyde + NH4(+) + phosphate
REACT:R-SSC-5693536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDC1 (Sus scrofa)
RHEA:57935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate
RHEA:45216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] = Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-RNO-4084912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arresten binds integrin alpha1beta1 (Rattus norvegicus)
RHEA:46192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine
REACT:R-SPO-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Schizosaccharomyces pombe)
REACT:R-BTA-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Bos taurus)
RHEA:39905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine
REACT:R-HSA-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Homo sapiens)
REACT:R-MMU-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Mus musculus)
RHEA:27657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + H(+) + pyruvate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2
REACT:R-BTA-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Bos taurus)
RHEA:11367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + pyruvate <=> AMP + 2 H(+) + phosphate + phosphoenolpyruvate
GO:0140292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-ribosylserine hydrolase activity
RHEA:49159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine
RHEA:16649	skos:prefLabel	"N-methylcoclaurine 3'-monooxygenase"
RHEA:16649	skos:altLabel	"(S)-N-methylcoclaurine 3'-hydroxylase"
RHEA:16649	skos:altLabel	"N-methylcoclaurine 3'-hydroxylase"
RHEA:16649	skos:altLabel	"CYP80B1"
RHEA:16649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-methylcoclaurine 3'-monooxygenase"
GO:0015057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin-activated receptor activity
GO:0015057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin receptor activity
GO:0015057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin receptor activity, G-protein coupled
REACT:R-DME-2187405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 binds phosphorylated SMAD2/3 (Drosophila melanogaster)
REACT:R-SSC-390674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB1 bind ADR,NAd (Sus scrofa)
RHEA:27412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a menaquinone + protoporphyrinogen IX <=> 3 a menaquinol + protoporphyrin IX
REACT:R-MMU-209738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 binds GC (Mus musculus)
RHEA:51959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylpropanal oxime <=> (Z)-2-methylpropanal oxime
RHEA:22190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O
REACT:R-BTA-5625426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde IFT (Bos taurus)
RHEA:63418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O => 2,6-dichlorohydroquinone + FADH2 + O2
RHEA:67528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-octenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine
REACT:R-DRE-9724290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR2 binds GNRH1,2 (Danio rerio)
REACT:R-HSA-9032315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxo-DHAs translocate from cytosol to extracellular region (Homo sapiens)
RHEA:52783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(hercyn-2-yl)-L-cysteine S-oxide <=> 2-sulfenohercynine + NH4(+) + pyruvate
REACT:R-CEL-2028679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Caenorhabditis elegans)
RHEA:56080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-L-serine + CDP-choline = [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)
RHEA:18514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + O2 => D-mannose + H2O2
REACT:R-GGA-6809393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filaments bind cell-cell adhesion complexes (Gallus gallus)
REACT:R-DME-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
REACT:R-SSC-204773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb7 (Sus scrofa)
RHEA:64774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol => S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine
REACT:R-HSA-9647631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds PIPs (Homo sapiens)
RHEA:21529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + H2O => [phosphate](n-1) + H(+) + phosphate
REACT:R-BTA-140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequestered tissue factor -> tissue factor (Bos taurus)
RHEA:29930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate(in) + Na(+)(in) <=> (R)-pantothenate(out) + Na(+)(out)
REACT:R-DRE-171122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL + LDLR => LDL:LDLR complex (Danio rerio)
RHEA:11515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicyl alcohol + UDP-alpha-D-glucose <=> H(+) + salicin + UDP
RHEA:16095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Danio rerio)
RHEA:36686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-hexadecanoyl-L-cysteinyl-[protein]
RHEA:21949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formamide + H2O => formate + NH4(+)
RHEA:70672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]
REACT:R-CEL-111742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)
REACT:R-SSC-199131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR binds CD226 (Sus scrofa)
REACT:R-XTR-174174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Xenopus tropicalis)
REACT:R-DDI-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Dictyostelium discoideum)
RHEA:30057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-oxobutanoate + H(+) + NADPH => L-allo-threonine + NADP(+)
REACT:R-CFA-6784676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)
RHEA:23421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + H2O => alpha,alpha-trehalose + phosphate
REACT:R-RNO-2022911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSPG is secreted (Rattus norvegicus)
RHEA:67587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-RNO-2731078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 2, (4) bind TGFB1 (Rattus norvegicus)
RHEA:61063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer + H(+) + UDP
REACT:R-HSA-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
REACT:R-HSA-1234166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
RHEA:53466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate => 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol
RHEA:59508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + L-cysteinyl-[protein] = S-(2-succinyl)-L-cysteinyl-[protein]
REACT:R-GGA-5660660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p300 acetylates RELA subunit (Gallus gallus)
REACT:R-MMU-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Mus musculus)
RHEA:50824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate
REACT:R-HSA-2466846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL can spontaneously react with PE to form NRPE (Homo sapiens)
REACT:R-DME-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Drosophila melanogaster)
RHEA:67034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]
GO:0042013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-19 binding
GO:0042013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-19 binding
REACT:R-BTA-9759549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Bos taurus)
GO:0047587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5alpha-hydroxysteroid dehydratase activity
GO:0047587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)
GO:0047587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity
GO:0047587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-alpha-hydroxysteroid dehydratase activity
RHEA:67705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate
RHEA:64480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate
REACT:R-XTR-193792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Xenopus tropicalis)
RHEA:18468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa + O2 <=> 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)
RHEA:33647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate
RHEA:60316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-HSA-5225602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR5 binds Me2sR3-replicative histone H3 (Homo sapiens)
REACT:R-SSC-5218824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds FYN (Sus scrofa)
REACT:R-HSA-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Homo sapiens)
RHEA:37231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alaninamide = L-alanine + NH4(+)
RHEA:28774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA <=> (9Z)-hexadecenoyl-CoA
REACT:R-SSC-203973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle budding (Sus scrofa)
GO:0016801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on ether bonds"
GO:0016801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on ether bonds
GO:0016801	skos:prefLabel	"Acting on ether bonds"
REACT:R-SSC-9688838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds STUB1 (Sus scrofa)
RHEA:26002	skos:altLabel	"D-arabitol 5-phosphate dehydrogenase"
RHEA:26002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol 1-phosphate + NAD(+) = D-xylulose 5-phosphate + H(+) + NADH
RHEA:26002	skos:altLabel	"D-arabitol 1-phosphate dehydrogenase"
RHEA:26002	skos:prefLabel	"D-arabitol-phosphate dehydrogenase"
RHEA:26002	skos:altLabel	"APDH"
RHEA:26002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arabitol-phosphate dehydrogenase"
RHEA:44336	skos:prefLabel	"L-arginine-specific L-amino acid ligase"
RHEA:44336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arginine-specific L-amino acid ligase"
RHEA:44336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + ATP + L-arginine = ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate
REACT:R-MMU-5607742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Mus musculus)
RHEA:65246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-hesperetin + UDP-alpha-D-glucose
REACT:R-MMU-418091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB1 (Mus musculus)
RHEA:37470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
REACT:R-BTA-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Bos taurus)
REACT:R-BTA-9700171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates PLCG1 (Bos taurus)
RHEA:69838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Saccharomyces cerevisiae)
REACT:R-GGA-9026894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK2 (Gallus gallus)
RHEA:22561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-vestitone + NADP(+) => 2'-hydroxyformononetin + 2 H(+) + NADPH
RHEA:28762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose <=> alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)
REACT:R-MMU-114254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS binds to APAF1 (Mus musculus)
RHEA:50314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + CO2 => 2-oxopentanoate + H(+)
RHEA:45074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-391941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLT receptors can bind LTB4 (Homo sapiens)
REACT:R-XTR-419001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Xenopus tropicalis)
RHEA:48492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP
REACT:R-DME-3780994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Drosophila melanogaster)
RHEA:16982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate + NAD(+) => H(+) + maleylacetate + NADH
REACT:R-MMU-2426259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Mus musculus)
RHEA:56822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cyclooctat-9-ene-5,7-diol + H2O => AH2 + cyclooctat-9-en-7-ol + O2
REACT:R-DRE-77319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Danio rerio)
REACT:R-HSA-9604642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
REACT:R-MMU-9012016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAHD1:Zn2+ dimer hydrolyses OA to PYR (Mus musculus)
GO:0004151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroorotase activity
GO:0004151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHOase activity
GO:0004151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-dihydroorotate amidohydrolase activity
GO:0004151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoylaspartic dehydrase activity
GO:0004151	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroorotate hydrolase activity
REACT:R-XTR-2022378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Xenopus tropicalis)
REACT:R-DME-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Drosophila melanogaster)
REACT:R-GGA-166817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by C3 convertases (Gallus gallus)
RHEA:55354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol => all-trans-retinol
GO:0000036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process
GO:0000036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl carrier activity
REACT:R-SSC-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Sus scrofa)
REACT:R-BTA-2467665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGRN binds Beta amyloid fibril via GAG chains (Bos taurus)
RHEA:29374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP + H2O <=> 2'-deoxyadenosine + phosphate
REACT:R-RNO-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Rattus norvegicus)
RHEA:42748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42748	skos:prefLabel	"16S rRNA (cytosine(967)-C(5))-methyltransferase"
RHEA:42748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (cytosine(967)-C(5))-methyltransferase"
REACT:R-DME-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Drosophila melanogaster)
RHEA:58580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate = acetate + catharanthine + H(+)
RHEA:63093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ilicicolin A + NADPH + O2 => H2O + ilicicolin A epoxide + NADP(+)
GO:1905060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels
GO:1905060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
RHEA:71999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II
REACT:R-MMU-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)
REACT:R-DME-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)
RHEA:36974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose
RHEA:21094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromacarpine + H(+) + S-adenosyl-L-homocysteine => 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine
REACT:R-MMU-209973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is diiodinated (Mus musculus)
REACT:R-DRE-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Danio rerio)
REACT:R-MMU-1433418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Mus musculus)
REACT:R-CFA-9686920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 ubiquitinates RIPK3 at K363 (Canis familiaris)
RHEA:12068	skos:altLabel	"holo-ACP synthase"
RHEA:12068	skos:altLabel	"L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase"
RHEA:12068	skos:altLabel	"PPTase"
RHEA:12068	skos:altLabel	"holo-ACP synthetase"
RHEA:12068	skos:altLabel	"acyl carrier protein holoprotein (holo-ACP) synthetase"
RHEA:12068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"holo-[acyl-carrier-protein] synthase"
RHEA:12068	skos:altLabel	"acyl carrier protein synthetase"
RHEA:12068	skos:altLabel	"alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase"
RHEA:12068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]
RHEA:12068	skos:altLabel	"ACPS"
RHEA:12068	skos:altLabel	"4'-phosphopantetheinyl transferase"
RHEA:12068	skos:prefLabel	"holo-[acyl-carrier-protein] synthase"
RHEA:12068	skos:altLabel	"acyl carrier protein synthase"
RHEA:12068	skos:altLabel	"holosynthase"
RHEA:12068	skos:altLabel	"P-pant transferase"
EC:1.1.1.213	skos:prefLabel	"3alpha-hydroxysteroid dehydrogenase (Re-specific)"
EC:1.1.1.213	skos:altLabel	"3alpha-hydroxysteroid dehydrogenase"
EC:1.1.1.213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha-hydroxysteroid dehydrogenase (Re-specific)"
EC:1.1.1.213	skos:altLabel	"3alpha-hydroxysteroid dehydrogenase (A-specific)"
RHEA:43914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9701548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDM1 gene expression downstream of ALK signaling (Homo sapiens)
RHEA:39042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-oxo fatty acid + H2O + NAD(+) <=> a dicarboxylate + 2 H(+) + NADH
RHEA:42365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-HSA-9683618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA3 is translated to protein 3a (Homo sapiens)
REACT:R-GGA-982810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation (Gallus gallus)
GO:0047576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoate dehalogenase activity
GO:0047576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-chlorobenzoate chlorohydrolase activity
GO:0047576	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	halobenzoate dehalogenase activity
RHEA:34954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate(out) <=> 3-hydroxypropanoate(in)
REACT:R-CFA-1296035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Canis familiaris)
REACT:R-BTA-450422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP recruits RNA degradation activities (Bos taurus)
REACT:R-HSA-164834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enzyme-bound ATP is released (Homo sapiens)
REACT:R-GGA-3238999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Gallus gallus)
RHEA:37967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NADP(+) = D-galactose + H(+) + NADPH
GO:0047971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanoate + H2O = 4-aminobutanoate + urea
GO:0047971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-guanidinobutyrate amidinohydrolase activity
GO:0047971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanidinobutyrate ureahydrolase activity
GO:0047971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinobutyrase activity
GO:0047971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-guanidinobutanoate amidinohydrolase activity
GO:0047971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	G-base activity
GO:0047971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GBH
GO:0047971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanidinobutyrase"
GO:0047971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-guanidobutyrase activity
GO:0047971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-guanidinobutyrate amidinobutyrase activity
GO:0047971	skos:prefLabel	"guanidinobutyrase"
REACT:R-MMU-8852552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1R autophosphorylates (Mus musculus)
GO:0034590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-hydroxyproline transmembrane transporter activity
GO:0034590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix (Homo sapiens)
GO:0034590	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	4-hydroxyproline transmembrane transporter activity
REACT:R-DRE-5610726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The IFT-A complex recruits TULP3 (Danio rerio)
RHEA:22691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + H2O + O2 <=> H2O2 + NH4(+) + pyruvate
REACT:R-RNO-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Rattus norvegicus)
RHEA:18117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + O2 = H2O + L-dopaquinone
REACT:R-BTA-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Bos taurus)
REACT:R-DRE-9029667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DFF dissociates from importin-alpha:importin-beta (Danio rerio)
RHEA:72287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dimethylsuccinate(out) + 3 Na(+)(out) = 2,2-dimethylsuccinate(in) + 3 Na(+)(in)
RHEA:72473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + D-threo-isocitrate(out) => citrate(out) + D-threo-isocitrate(in)
REACT:R-CEL-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Caenorhabditis elegans)
GO:0018575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorocatechol 1,2-dioxygenase activity
REACT:R-HSA-9008271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Homo sapiens)
REACT:R-DRE-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Danio rerio)
RHEA:35001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + ATP(in) => ADP(in) + ATP(out)
REACT:R-CFA-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Canis familiaris)
REACT:R-HSA-9626039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pGFAP binds GFAP in LAMP2a multimer (Homo sapiens)
REACT:R-HSA-8854736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 binds FLT3 (Homo sapiens)
REACT:R-DRE-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Danio rerio)
REACT:R-DME-5695957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Drosophila melanogaster)
RHEA:27545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde
RHEA:53320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)
RHEA:53320	skos:prefLabel	"mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase"
RHEA:53320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase"
REACT:R-SPO-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Schizosaccharomyces pombe)
EC:3.4.19.5	skos:prefLabel	"beta-aspartyl-peptidase"
EC:3.4.19.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-aspartyl-peptidase"
REACT:R-RNO-8848993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated KHDRBS1 translocates to the cytosol (Rattus norvegicus)
REACT:R-XTR-375140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds promyogenic cadherins (Xenopus tropicalis)
RHEA:69591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + UMP <=> IMP + uridine
RHEA:21147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:71313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-alanine(in) + 2 Na(+)(in) => chloride(out) + L-alanine(out) + 2 Na(+)(out)
REACT:R-SSC-5610767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Sus scrofa)
REACT:R-SSC-9645414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Sus scrofa)
REACT:R-HSA-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Homo sapiens)
REACT:R-CFA-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Canis familiaris)
REACT:R-XTR-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Xenopus tropicalis)
RHEA:35421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose
RHEA:40530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinol + 4 H(+)(in) + O2(in) <=> 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exocellulase activity
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-1,4-beta-glucanase activity
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan 1,4-beta-glucosidase activity
GO:0031217	skos:prefLabel	"glucan 1,4-beta-glucosidase"
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,4-beta-D-glucosidase activity
GO:0031217	skos:altLabel	"exo-1,4-beta-D-glucosidase"
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-beta-1,4-glucanase activity
GO:0031217	skos:altLabel	"exo-1,4-beta-glucanase"
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-1,4-beta-glucanase activity
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1,4-beta-D-glucan glucohydrolase activity
GO:0031217	skos:altLabel	"1,4-beta-D-glucan glucohydrolase"
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan 1,4-beta-glucosidase"
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-beta-1,4-glucosidase activity
GO:0031217	skos:altLabel	"exo-1,4-beta-glucosidase"
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-1,4-glucanase activity
GO:0031217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-1,4-beta-glucosidase activity
RHEA:52879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-DDI-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Dictyostelium discoideum)
GO:0008172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyltransferase activity
REACT:R-GGA-9620456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sGC stimulators bind sGC:NO (Gallus gallus)
REACT:R-RNO-9647619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD forms ring‐shaped oligomers  (Rattus norvegicus)
REACT:R-DRE-199298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CREB1 (Danio rerio)
REACT:R-MMU-2396079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds Plasminogen activator inhibitor- 1 (Mus musculus)
RHEA:15649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamate + 2 H(+) = CO2 + NH4(+)
REACT:R-SSC-9023912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO2 cleaves passenger strand of duplex siRNA (Sus scrofa)
REACT:R-BTA-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Bos taurus)
GO:0047640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, D-aldohexose
GO:0047640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aldose:NAD+ 1-oxidoreductase activity
GO:0047640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldose dehydrogenase activity
GO:0047640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldopyranose + NAD(+) = aldono-1,5-lactone + H(+) + NADH
GO:0047640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldose 1-dehydrogenase activity
RHEA:25135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + pyridoxamine = H2O + pyridoxamine 5'-phosphate
RHEA:22838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] => a fatty acyl-[ACP] + H(+) + malonyl-[ACP]
RHEA:58498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolaldehyde + H2O + NAD(+) + trimethylamine => choline + H(+) + NADH + O2
RHEA:66494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:19465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate
RHEA:19465	skos:prefLabel	"nitric oxide dioxygenase"
RHEA:19465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitric oxide dioxygenase"
RHEA:19465	skos:altLabel	"NOD"
RHEA:19465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate
RHEA:43157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine
RHEA:64266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrochrysone + CO2 => atrochrysone carboxylate + H(+)
RHEA:38993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-HSA-1299297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of THIK (Homo sapiens)
RHEA:67891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine <=> 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-209944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(OH)D binds GC (Homo sapiens)
REACT:R-RNO-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Rattus norvegicus)
RHEA:43582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + iminoarginine => A + D-arginine
RHEA:16317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH
RHEA:37512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:56239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine
RHEA:41129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycerol + H(+) + phosphocholine => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:13729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FAD-AMP lyase (cyclizing)"
RHEA:13729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD = AMP + H(+) + riboflavin cyclic-4',5'-phosphate
RHEA:13729	skos:altLabel	"FMN cyclase"
RHEA:13729	skos:prefLabel	"FAD-AMP lyase (cyclizing)"
RHEA:19601	skos:prefLabel	"orcinol 2-monooxygenase"
RHEA:19601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"orcinol 2-monooxygenase"
RHEA:19601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD(+)
RHEA:19601	skos:altLabel	"orcinol hydroxylase"
RHEA:70297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfinopyruvate + L-glutamate => 2-oxoglutarate + 3-sulfino-L-alanine
REACT:R-SSC-4647594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAHF formation (Sus scrofa)
REACT:R-CEL-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Caenorhabditis elegans)
RHEA:21427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH
REACT:R-GGA-9749986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Gallus gallus)
REACT:R-MMU-5362448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh C-terminal fragments are degraded by the proteasome (Mus musculus)
REACT:R-HSA-8858435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSPAN7 binds PICK1 (Homo sapiens)
RHEA:39712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) => 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-HSA-180606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Vpu with CD4 (Homo sapiens)
EC:3.4.24.79	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pappalysin-1"
EC:3.4.24.79	skos:altLabel	"insulin-like growth factor binding protein-4 protease"
EC:3.4.24.79	skos:altLabel	"pregnancy-associated plasma protein-A"
EC:3.4.24.79	skos:prefLabel	"pappalysin-1"
RHEA:68144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl 3-oxobutanoate + H(+) + NADPH = ethyl (R)-3-hydroxybutanoate + NADP(+)
RHEA:42761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H2O + NAD(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADH
REACT:R-MMU-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Mus musculus)
REACT:R-GGA-9693324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disulfiram covalently modifies Cys191 in GSDMD (Gallus gallus)
RHEA:39257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+) => (13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH
RHEA:52914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O => 3-dimethylallyl-4-hydroxymandelate + O2
REACT:R-GGA-2064421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds ZO-2 (TJP2) (Gallus gallus)
REACT:R-DRE-71588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Danio rerio)
RHEA:42125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol + NAD(+) => androsterone + H(+) + NADH
RHEA:52605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)
RHEA:71425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)
RHEA:51121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 => (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O
RHEA:60855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine
REACT:R-HSA-9688831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK3 at K55, K363 (Homo sapiens)
RHEA:51453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate => beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0008684	skos:prefLabel	"2-oxopent-4-enoate hydratase"
GO:0008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxopent-4-enoate hydratase"
GO:0008684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-4-pentenoate hydratase activity
GO:0008684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)
GO:0008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O
GO:0008684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OEH activity
GO:0008684	skos:altLabel	"2-keto-4-pentenoate hydratase"
GO:0008684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-4-pentenoate (vinylpyruvate)hydratase activity
GO:0008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopent-4-enoate hydratase activity
GO:0008684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-oxopentanoate hydro-lyase activity
GO:0008684	skos:altLabel	"OEH"
REACT:R-DRE-2046180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSPG is secreted from the cell (Danio rerio)
REACT:R-HSA-158300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Homo sapiens)
REACT:R-XTR-8878787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPI dimer hydrolyses phosphate monoesters (Xenopus tropicalis)
REACT:R-BTA-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Bos taurus)
RHEA:21965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acylcholine + H2O => a carboxylate + choline + H(+)
REACT:R-GGA-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Gallus gallus)
REACT:R-RNO-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
REACT:R-HSA-9769014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 stimulates GEM gene expression (Homo sapiens)
REACT:R-HSA-5689630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BAP1-interacting complex (Homo sapiens)
REACT:R-GGA-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
REACT:R-DRE-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Danio rerio)
GO:0043956	skos:altLabel	"3-hydroxypropionyl-CoA hydro-lyase"
GO:0043956	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetyl-coenzyme A synthetase/GroES-like domain
GO:0043956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropionyl-CoA dehydratase activity
GO:0043956	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	AMP-dependent synthetase and ligase
GO:0043956	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetyl-coenzyme A synthetase
GO:0043956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy propionyl-CoA dehydratase activity
GO:0043956	skos:altLabel	"3-hydroxypropanoate-CoA dehydratase"
GO:0043956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxypropionyl-CoA dehydratase"
GO:0043956	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	enoyl-CoA hydratase/isomerase
GO:0043956	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase
GO:0043956	skos:prefLabel	"3-hydroxypropionyl-CoA dehydratase"
GO:0016161	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycogenase activity
GO:0016161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-alpha-D-glucan maltohydrolase activity
GO:0016161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta amylase activity
GO:0016161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amylase activity
GO:0016161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	saccharogen amylase activity
REACT:R-RNO-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Rattus norvegicus)
REACT:R-HSA-9661745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An unknown BILR reduces BIL to D-UBGN (Homo sapiens)
REACT:R-DRE-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Danio rerio)
REACT:R-HSA-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Homo sapiens)
REACT:R-MMU-6809263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)
REACT:R-HSA-9683429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 binds nsp10 (Homo sapiens)
RHEA:54759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deamido-NAD(+) + hydrogencarbonate <=> AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide
RHEA:38864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sucrose 6(F)-phosphate => alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate
GO:0102036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
REACT:R-MMU-9609310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β-blockers bind ADRB1,2,3 (Mus musculus)
REACT:R-RNO-4084994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU3 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)
RHEA:52074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-hexadecenoyloxy)-octadecanoate + H2O
RHEA:71231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + H(+) + NAD(+)
GO:0140032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosylation-dependent protein binding
EC:2.10.-.-	skos:prefLabel	"Transferring molybdenum- or tungsten-containing groups"
EC:2.10.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring molybdenum- or tungsten-containing groups"
RHEA:47736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-5674366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RD binds p-2S MAP2Ks and MAPKs (Caenorhabditis elegans)
RHEA:67281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione => (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione
RHEA:30351	skos:prefLabel	"pyrrole-2-carboxylate monooxygenase"
RHEA:30351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrrole-2-carboxylate monooxygenase"
RHEA:30351	skos:altLabel	"pyrrole-2-carboxylate oxygenase"
RHEA:30351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + pyrrole-2-carboxylate = 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)
RHEA:37511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-XTR-8987236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Xenopus tropicalis)
REACT:R-CFA-188979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Canis familiaris)
REACT:R-HSA-8950410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B:IL12B translocates from ER lumen to the extracellular region (Homo sapiens)
REACT:R-CFA-5654662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
REACT:R-DRE-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Danio rerio)
REACT:R-SSC-6805470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates TP53 (Sus scrofa)
EC:5.1.3.9	skos:prefLabel	"N-acylglucosamine-6-phosphate 2-epimerase"
EC:5.1.3.9	skos:altLabel	"N-acetylmannosamine-6-phosphate 2-epimerase"
EC:5.1.3.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acylglucosamine-6-phosphate 2-epimerase"
EC:5.1.3.9	skos:altLabel	"acylmannosamine phosphate 2-epimerase"
EC:5.1.3.9	skos:altLabel	"N-acetylglucosmamine 6-phosphate 2-epimerase"
EC:5.1.3.9	skos:altLabel	"acylglucosamine-6-phosphate 2-epimerase"
EC:5.1.3.9	skos:altLabel	"acylglucosamine phosphate 2-epimerase"
REACT:R-MMU-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Mus musculus)
RHEA:50953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-chloro-L-tryptophan + AH2 + O2 => A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin
RHEA:54840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + octan-3-one = H2O + NADP(+) + pentyl propanoate
REACT:R-SSC-2730844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GRB2:SOS complex with p-SHC1 (Sus scrofa)
REACT:R-SSC-174171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A with the APC/C (Sus scrofa)
REACT:R-MMU-5607043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa associates with cell membrane (Mus musculus)
REACT:R-SSC-2213241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of nonameric complex (Sus scrofa)
GO:0008689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-demethylubiquinone-9 methyltransferase activity
GO:0008689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-9 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-9
GO:0008689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OMHMB-methyltransferase activity
GO:0008689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinone-9 3-O-methyltransferase activity
GO:0008689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity
GO:0008689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity
GO:0070137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conjugating protein-specific endopeptidase activity
GO:0070137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein-specific endopeptidase activity
RHEA:69266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an isothiocyanate + sulfate => a (Z)-N-(sulfonatooxy)alkanimidothioate
REACT:R-RNO-389481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 1 receptor can bind orexin-A neuropeptide (Rattus norvegicus)
RHEA:58616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-octanoyl-(2S)-hydroxyglycine = glyoxylate + octanamide
REACT:R-MMU-5672957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates KSR1 (Mus musculus)
REACT:R-CFA-416985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to synapse (Canis familiaris)
REACT:R-SPO-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Schizosaccharomyces pombe)
REACT:R-HSA-6805730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD9 methylates TP53 (Homo sapiens)
RHEA:60387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin + H2O <=> N-(2,3-dihydroxybenzoyl)-L-serine trimer
RHEA:46750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamate + 2 H(+) + phosphate => carboxyphosphate + NH4(+)
RHEA:23592	skos:prefLabel	"D/L-glyceraldehyde reductase"
RHEA:23592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH
RHEA:23592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D/L-glyceraldehyde reductase"
RHEA:23592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH
RHEA:23592	skos:prefLabel	"glycerol dehydrogenase (NADP(+))"
RHEA:23592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol dehydrogenase (NADP(+))"
REACT:R-DME-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Drosophila melanogaster)
REACT:R-RNO-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Rattus norvegicus)
RHEA:64716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propanal = acrolein + H(+) + NADPH
RHEA:27347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+) => FMNH2 + O2
RHEA:71165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanine(in) + Na(+)(in) => H(+)(in) + L-alanine(out) + Na(+)(out)
RHEA:47206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-199839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate RSK (Drosophila melanogaster)
REACT:R-SSC-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Sus scrofa)
RHEA:43643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + CoA
REACT:R-XTR-167429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex  binds GTP (Xenopus tropicalis)
REACT:R-BTA-163825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)
REACT:R-DRE-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Danio rerio)
GO:0008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyprenyl p-hydroxybenzoate decarboxylase activity
GO:0008694	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UbiD
GO:0008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity
GO:0008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GO:0008694	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UbiX
GO:0008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPHB decarboxylase activity
GO:0008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-octaprenyl-4-hydroxybenzoate decarboxylase activity
GO:0008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-polyprenyl 4-hydroxybenzoate decarboxylase activity
REACT:R-DRE-9013111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GAPs stimulate RHOC GTPase activity (Danio rerio)
RHEA:70627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-CEL-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Caenorhabditis elegans)
RHEA:45199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] <=> 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bis(5'-adenosyl)-tetraphosphatase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Ap(4)Aase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Homo sapiens)
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Ap4A hydrolase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Ap(4)A hydrolase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	diguanosinetetraphosphatase (asymmetrical) activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	diadenosinetetraphosphatase (asymmetrical) activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dinucleoside tetraphosphatase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dinucleosidetetraphosphatase (asymmetrical) activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bis(5'-guanosyl)-tetraphosphatase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Ap4Aase activity
GO:0004081	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine P1,P4-tetraphosphatase activity
REACT:R-SPO-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Schizosaccharomyces pombe)
RHEA:58977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonaldehyde + O2 => 3-oxopropanoate + H(+) + H2O2
REACT:R-HSA-374214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)
RHEA:65829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neryl diphosphate => diphosphate + nerol
REACT:R-SSC-180073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Sus scrofa)
EC:3.4.21.20	skos:prefLabel	"cathepsin G"
EC:3.4.21.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin G"
REACT:R-SPO-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Schizosaccharomyces pombe)
REACT:R-DME-5610767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Drosophila melanogaster)
REACT:R-DRE-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)
REACT:R-GGA-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Gallus gallus)
REACT:R-BTA-914012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Bos taurus)
REACT:R-CFA-6794346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind NLGNs (Canis familiaris)
REACT:R-DDI-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Dictyostelium discoideum)
REACT:R-MMU-176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST trimers transfer GS from GSH to luminal substrates (Mus musculus)
REACT:R-CFA-5607023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IXa associates with cell membrane (Canis familiaris)
REACT:R-DRE-9706393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds ATP (Danio rerio)
REACT:R-HSA-3899291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of EP300 with SUMO1 (Homo sapiens)
REACT:R-RNO-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Rattus norvegicus)
REACT:R-SPO-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Schizosaccharomyces pombe)
RHEA:52804	skos:prefLabel	"(+)-eremophilene synthase"
RHEA:52804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-eremophilene synthase"
RHEA:52804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate
RHEA:58641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine => a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine
REACT:R-XTR-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Xenopus tropicalis)
REACT:R-DRE-9009065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXA1 and GATA3 bind to CCND1 promoter (Danio rerio)
REACT:R-CFA-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)
RHEA:55301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
RHEA:52458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP => testosterone + UDP-alpha-D-glucuronate
REACT:R-CFA-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Canis familiaris)
REACT:R-DRE-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Danio rerio)
REACT:R-MMU-1482776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Mus musculus)
REACT:R-SCE-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Saccharomyces cerevisiae)
RHEA:58315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-substituted-cholesteryl beta-D-glucoside + H2O <=> 25-substituted-cholesterol + D-glucose
RHEA:26134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O
RHEA:20956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA
RHEA:20956	skos:prefLabel	"phenylacetate--CoA ligase"
RHEA:20956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetate--CoA ligase"
REACT:R-DDI-9018907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Dictyostelium discoideum)
REACT:R-CEL-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Caenorhabditis elegans)
REACT:R-MMU-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Mus musculus)
REACT:R-BTA-877198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates membrane pores that include pannexin-1 (Bos taurus)
RHEA:39634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH <=> (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)
REACT:R-GGA-83803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Gallus gallus)
REACT:R-HSA-9617927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO4 binds ATXN3 (Homo sapiens)
GO:0106361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]
GO:0106361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine rhamnosyltransferase activity
RHEA:13325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine 6-dehydrogenase"
RHEA:13325	skos:altLabel	"UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase"
RHEA:13325	skos:prefLabel	"UDP-N-acetylglucosamine 6-dehydrogenase"
RHEA:13325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate
REACT:R-HSA-390329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of AKT by PP2A (Homo sapiens)
RHEA:18687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+) => H(+) + NADPH + O2 + pentachlorophenol
REACT:R-SPO-1675780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Schizosaccharomyces pombe)
GO:0036202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene 11-hydroxylase activity
GO:0036202	skos:prefLabel	"ent-cassa-12,15-diene 11-hydroxylase"
GO:0036202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-cassa-12,15-diene 11-hydroxylase"
GO:0036202	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ent-cassadiene C11alpha-hydroxylase activity
GO:0036202	skos:altLabel	"ent-cassadiene C11alpha-hydroxylase"
GO:0036202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0036202	skos:altLabel	"CYP76M7"
REACT:R-HSA-606287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSF complex binds the centromere (Homo sapiens)
REACT:R-HSA-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Homo sapiens)
RHEA:72031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + O2 = (E)-sinapaldehyde + H2O2
REACT:R-RNO-374248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR3 binds ligands CXCL9 to 11 (Rattus norvegicus)
REACT:R-RNO-4084978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Rattus norvegicus)
REACT:R-BTA-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Bos taurus)
REACT:R-GGA-6807027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 and PTPN2 dephosphorylate MET (Gallus gallus)
REACT:R-GGA-9757706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Gallus gallus)
REACT:R-SSC-9606151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)
RHEA:29991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-lyxopyranose(in) = H(+)(out) + L-lyxopyranose(out)
RHEA:18355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate => ATP + H2O + K(+)(out) + Na(+)(in)
RHEA:41664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + NAD(+) = chelirubine + NADH
RHEA:25527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> 9alpha-copalyl diphosphate
RHEA:20439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH => 5D-5-O-methyl-chiro-inositol + NADP(+)
RHEA:66861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + 4 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate
REACT:R-DME-5654594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
RHEA:72999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophanyl aminopeptidase"
RHEA:72999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] = L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]
RHEA:72999	skos:prefLabel	"tryptophanyl aminopeptidase"
RHEA:72999	skos:altLabel	"tryptophan aminopeptidase"
REACT:R-RNO-4755411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates IKBKG with SUMO1 (Rattus norvegicus)
RHEA:63830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + vanillylamine => L-alanine + vanillin
GO:0052915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23S rRNA (guanine(2445)-N(2))-methyltransferase activity
GO:0052915	skos:prefLabel	"23S rRNA (guanine(2445)-N(2))-methyltransferase"
GO:0052915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (guanine(2445)-N(2))-methyltransferase"
GO:0052915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-BTA-389826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NADPH + H+ => glycolate + NADP+ (Bos taurus)
REACT:R-HSA-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Homo sapiens)
EC:4.4.1.37	skos:altLabel	"P2TMN synthase"
EC:4.4.1.37	skos:altLabel	"pyridinium-3,5-biscarboxylic acid mononucleotide sulfurtransferase"
EC:4.4.1.37	skos:altLabel	"P2CMN sulfurtransferase"
EC:4.4.1.37	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase"
EC:4.4.1.37	skos:prefLabel	"pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase"
RHEA:11979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anhydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrotetracycline + H2O + NADP(+)
REACT:R-XTR-5696119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Xenopus tropicalis)
REACT:R-HSA-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Homo sapiens)
REACT:R-DME-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Drosophila melanogaster)
GO:0001785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin J receptor activity
GO:0001785	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGJ receptor activity
GO:0001785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGJ(2) receptor activity
GO:0070576	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cholecalciferol 24-hydroxylase activity
GO:0070576	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calciferol 24-hydroxylase activity
GO:0070576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin D 24-hydroxylase activity
GO:0070576	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin D2 24-hydroxylase activity
GO:0070576	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin D3 24-hydroxylase activity
GO:0070576	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ergocalciferol 24-hydroxylase activity
REACT:R-XTR-8848077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAP2 (Xenopus tropicalis)
REACT:R-HSA-9749590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates ALB (Homo sapiens)
RHEA:71797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate(in) + H(+)(in) => (R)-3-hydroxybutanoate(out) + H(+)(out)
RHEA:47728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)
RHEA:45580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-galactarolactone isomerase"
RHEA:45580	skos:prefLabel	"D-galactarolactone isomerase"
RHEA:45580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactaro-1,5-lactone = D-galactaro-1,4-lactone
REACT:R-SSC-9020261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Sus scrofa)
REACT:R-HSA-9611852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB3 bind ADR,NAd (Homo sapiens)
REACT:R-CEL-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Caenorhabditis elegans)
RHEA:33149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + daunorubicin(out) + H(+) + phosphate => ATP + daunorubicin(in) + H2O
REACT:R-RNO-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Rattus norvegicus)
REACT:R-GGA-8981093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12 bound to IL12R internalises (Gallus gallus)
REACT:R-DRE-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Danio rerio)
RHEA:37513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA
REACT:R-GGA-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Gallus gallus)
REACT:R-DRE-8870332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Danio rerio)
REACT:R-CFA-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Canis familiaris)
REACT:R-SSC-373339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Sus scrofa)
RHEA:67126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + S-hydroxy-L-cysteinyl-[protein] => a hydroperoxide + L-cysteinyl-[protein]
RHEA:44270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA
REACT:R-DRE-429730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Danio rerio)
REACT:R-DRE-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Danio rerio)
RHEA:36701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-desmethylnovobiocic acid + AMP + diphosphate => 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP
RHEA:55455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Caenorhabditis elegans)
REACT:R-CFA-114252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-3 by the apoptosome (Canis familiaris)
REACT:R-DDI-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)
GO:0045135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alginase I
GO:0045135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alginase activity
GO:0045135	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alginate lyase I activity
GO:0045135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alginate lyase activity
GO:0045135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly(beta-D-mannuronate) lyase activity
GO:0045135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(beta-D-1,4-mannuronide) lyase activity
GO:0045135	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	poly(mana) alginate lyase activity
RHEA:36930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA
REACT:R-BTA-5218854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y420-FYN is phosphorylated on S21 (Bos taurus)
RHEA:15822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + glycine => 2 AH2 + CO2 + hydrogen cyanide
RHEA:40689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol
RHEA:32324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-203774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Csk with PAG (Homo sapiens)
REACT:R-SPO-6811504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 dephosphorylation by PP2A-B56-beta,gamma (Schizosaccharomyces pombe)
RHEA:19867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 CO2 + coproporphyrinogen III => 4 H(+) + uroporphyrinogen III
REACT:R-XTR-5649873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Xenopus tropicalis)
REACT:R-BTA-8848436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CDKN1B (Bos taurus)
RHEA:52761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate
REACT:R-SSC-374909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabolism of Noradrenaline (Sus scrofa)
REACT:R-CEL-6809325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-nitrophenol sulfotransferase activity
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenol sulfotransferase activity
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arylsulfotransferase
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopamine sulfotransferase activity
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-naphtholsulfotransferase activity
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfokinase activity
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryl sulfotransferase activity
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenol sulfokinase activity
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-nitrocatechol sulfokinase activity
GO:0004062	skos:altLabel	"sulfokinase"
GO:0004062	skos:altLabel	"phenol sulfotransferase"
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aryl sulfotransferase"
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ritodrine sulfotransferase activity
GO:0004062	skos:prefLabel	"aryl sulfotransferase"
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-naphthol phenol sulfotransferase activity
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryl sulphotransferase activity
GO:0004062	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PST
EC:4.2.2.18	skos:prefLabel	"inulin fructotransferase (DFA-III-forming)"
EC:4.2.2.18	skos:altLabel	"inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming)"
EC:4.2.2.18	skos:altLabel	"inulin fructotransferase (depolymerizing)"
EC:4.2.2.18	skos:altLabel	"inulin fructotransferase (DFA-III-producing)"
EC:4.2.2.18	skos:altLabel	"inulase II"
EC:4.2.2.18	skos:altLabel	"inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming)"
EC:4.2.2.18	skos:altLabel	"inulinase II"
EC:4.2.2.18	skos:altLabel	"inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride)"
EC:4.2.2.18	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inulin fructotransferase (DFA-III-forming)"
REACT:R-MMU-350058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL NCOR corepressor complex (Mus musculus)
REACT:R-MMU-374298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid receptors bind opioid peptides (Mus musculus)
REACT:R-DDI-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Dictyostelium discoideum)
REACT:R-PFA-936895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7B transports cytosolic Cu2+ to Golgi lumen (Plasmodium falciparum)
REACT:R-GGA-443418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b signaling involves c-Src (Gallus gallus)
REACT:R-MMU-162729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Mus musculus)
RHEA:47305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-GGA-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Gallus gallus)
RHEA:58334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-enal + H(+) + NADPH => (E)-non-2-en-1-ol + NADP(+)
REACT:R-SSC-1307963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Sus scrofa)
REACT:R-GGA-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Gallus gallus)
REACT:R-GGA-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Gallus gallus)
REACT:R-HSA-5579018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1(868-1441) binds PAX3(1-319) (Homo sapiens)
RHEA:30857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene + H2O => dammarenediol-II
REACT:R-CEL-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Caenorhabditis elegans)
REACT:R-MMU-5654714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
RHEA:55365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 6 diphosphate
RHEA:23574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + 4 CoA + phlorisovalerophenone => 3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA
REACT:R-CFA-1605724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Canis familiaris)
RHEA:24255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate <=> 2 ADP + 2 H(+)
REACT:R-CEL-428750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq activation by TP receptor (Caenorhabditis elegans)
REACT:R-HSA-202307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Change of PKC theta conformation (Homo sapiens)
REACT:R-GGA-210291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Gallus gallus)
RHEA:42071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH <=> clavulanate + NADP(+)
RHEA:21489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)
REACT:R-MMU-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Mus musculus)
RHEA:42378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O
REACT:R-CFA-5663050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHI and DHICA polymerise forming eumelanin (Canis familiaris)
REACT:R-CEL-9693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds 5HT (Caenorhabditis elegans)
REACT:R-DME-2396009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds c-di-GMP (Drosophila melanogaster)
RHEA:32020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => beta-cubebene + diphosphate
RHEA:72716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoate + ATP + H(+) => (R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate
RHEA:14301	skos:prefLabel	"4-pyridoxolactonase"
RHEA:14301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxolactone + H2O = 4-pyridoxate + H(+)
RHEA:14301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-pyridoxolactonase"
RHEA:43294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O
RHEA:41589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)
REACT:R-HSA-8866858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR F508del is degraded by the 26S proteasome (Homo sapiens)
EC:1.1.1.118	skos:prefLabel	"glucose 1-dehydrogenase (NAD(+))"
EC:1.1.1.118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose 1-dehydrogenase (NAD(+))"
REACT:R-GGA-113402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:early elongation complex (Gallus gallus)
RHEA:47815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)
REACT:R-DME-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)
REACT:R-RNO-9661397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)
REACT:R-HSA-1605428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ESRRA (ERR1, ERRalpha) (Homo sapiens)
REACT:R-BTA-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Bos taurus)
REACT:R-SPO-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Schizosaccharomyces pombe)
RHEA:62314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + salicylate 2-O-beta-D-glucoside + UDP => salicylate + UDP-alpha-D-glucose
REACT:R-DME-211178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO1A is excluded from the nucleus (Drosophila melanogaster)
REACT:R-XTR-5340320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTP transports GSL from plasma membrane to ER membrane (Xenopus tropicalis)
RHEA:53082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate
RHEA:35254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate
REACT:R-SSC-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Sus scrofa)
RHEA:26544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-piperazine-2-carboxylate + NH4(+) => (R)-piperazine-2-carboxamide + H2O
REACT:R-HSA-1982065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of overexpressed FGFR1b (Homo sapiens)
RHEA:66532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]
GO:0016423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (guanosine) methyltransferase activity
GO:0016423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (guanine) methyltransferase activity
REACT:R-HSA-5617866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXC4 gene is transcribed (Homo sapiens)
RHEA:11974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12 H(+) + 4 iron(III) oxide-hydroxide => 4 Fe(2+) + 6 H2O + O2
RHEA:41075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)
GO:0008061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitin binding
REACT:R-BTA-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Bos taurus)
REACT:R-PFA-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Plasmodium falciparum)
REACT:R-SSC-9701003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 heterodimer (Sus scrofa)
REACT:R-CFA-73635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Canis familiaris)
REACT:R-DRE-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Danio rerio)
REACT:R-DME-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Drosophila melanogaster)
RHEA:57639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate
REACT:R-SSC-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Sus scrofa)
REACT:R-HSA-877361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyrin binds ASC (Homo sapiens)
REACT:R-BTA-191299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene is oxidized to its epoxide (Bos taurus)
REACT:R-DDI-2872498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Dictyostelium discoideum)
RHEA:34567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-paratose synthase"
RHEA:34567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-paratose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH
RHEA:34567	skos:prefLabel	"CDP-paratose synthase"
REACT:R-XTR-445113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Urotensin-2 receptor binds urotensin-2 and 2B (Xenopus tropicalis)
RHEA:47734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine
GO:0140474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER-mitochondrion membrane adaptor activity
GO:0140474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrion-ER membrane adaptor activity
GO:0140474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrion-endoplasmic reticulum membrane tether activity
GO:0140474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoplasmic reticulum-mitochondrion membrane adaptor activity
GO:0140474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrion-endoplasmic reticulum membrane adaptor activity
GO:0140474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrion-ER membrane tether activity
GO:0140474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoplasmic reticulum-mitochondrion membrane tether activity
GO:0140474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER-mitochondrion membrane tether activity
REACT:R-DME-8948832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 polyubiquitinates PARylated PTEN (Drosophila melanogaster)
REACT:R-CFA-202723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha5beta1 binds FN1 dimer (Canis familiaris)
REACT:R-RNO-9027272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Rattus norvegicus)
RHEA:70776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-D-quinovose + FMNH2 + O2 => 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite
REACT:R-RNO-110375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Rattus norvegicus)
REACT:R-DDI-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Dictyostelium discoideum)
REACT:R-SSC-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Sus scrofa)
REACT:R-XTR-5576895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Xenopus tropicalis)
GO:0018455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alcohol:NAD(P)+ oxidoreductase activity
GO:0018455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH
GO:0018455	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde reductase (NADPH/NADH)
GO:0018455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol dehydrogenase [NAD(P)+] activity
RHEA:13494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH
REACT:R-MMU-5607732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TAK1 autophosphorylates (Mus musculus)
REACT:R-BTA-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Bos taurus)
REACT:R-RNO-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Rattus norvegicus)
REACT:R-SPO-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Schizosaccharomyces pombe)
REACT:R-DME-9686980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 recruits APC/C:Cdh1 complex to SKP2 (Drosophila melanogaster)
RHEA:54418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campest-4-en-3-one + H(+) + NADPH => 5alpha-campestan-3-one + NADP(+)
REACT:R-HSA-8938371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2:CBFB binds the LGALS3 gene promoter (Homo sapiens)
REACT:R-RNO-909725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IRF9 with p-STAT2:p-STAT1 (Rattus norvegicus)
REACT:R-BTA-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Bos taurus)
RHEA:39063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + scyllo-inositol = H(+) + NADPH + scyllo-inosose
RHEA:39063	skos:prefLabel	"scyllo-inositol 2-dehydrogenase (NADP(+))"
RHEA:39063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scyllo-inositol 2-dehydrogenase (NADP(+))"
REACT:R-CFA-5617037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Canis familiaris)
RHEA:30742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + H2O <=> myo-inositol + phosphate
REACT:R-SSC-2161899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Sus scrofa)
RHEA:60326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine
REACT:R-HSA-9694733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand) (Homo sapiens)
REACT:R-SPO-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)
RHEA:55753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:24075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O
REACT:R-MMU-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Mus musculus)
REACT:R-HSA-9021183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 mRNA translation is inhibited by miR-132 (Homo sapiens)
RHEA:49054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperlicin E + H2O + NAD(+) => asperlicin C + H(+) + NADH + O2
REACT:R-SSC-9611852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB3 bind ADR,NAd (Sus scrofa)
REACT:R-SPO-73912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Schizosaccharomyces pombe)
RHEA:27749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-cysteine <=> CO2 + cysteamine
RHEA:42963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] <=> NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]
RHEA:45147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)acryloyl-CoA + 2 H2O <=> acetaldehyde + CO2 + CoA + methanethiol
REACT:R-CFA-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Canis familiaris)
REACT:R-RNO-8855617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Rattus norvegicus)
REACT:R-BTA-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Bos taurus)
REACT:R-CFA-9714481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the ER membrane (Canis familiaris)
RHEA:29826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) <=> chloride(out)
RHEA:13891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + FMN + 2 H(+) => FAD + H2O
REACT:R-RNO-5654148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR3 (Rattus norvegicus)
RHEA:49795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + glycine <=> CoA + H(+) + N-eicosanoylglycinate
REACT:R-XTR-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Xenopus tropicalis)
RHEA:51182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine
REACT:R-HSA-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Homo sapiens)
REACT:R-SSC-212706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipase C-gamma1 binds to the activated EGF receptor (Sus scrofa)
RHEA:21702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O
RHEA:28712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) => H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)
REACT:R-CEL-9638075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from DS (Caenorhabditis elegans)
RHEA:50676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein N-terminal asparagine amidohydrolase"
RHEA:50676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-terminal L-asparaginyl-[protein] = N-terminal L-aspartyl-[protein] + NH4(+)
RHEA:50676	skos:prefLabel	"protein N-terminal asparagine amidohydrolase"
RHEA:47639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine + NADP(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)
REACT:R-XTR-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Xenopus tropicalis)
RHEA:54459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
REACT:R-RNO-6785126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA core complex assembles at DNA interstrand crosslinks (ICLs) (Rattus norvegicus)
REACT:R-DRE-165777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4B by activated S6K1 (Danio rerio)
REACT:R-DDI-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Dictyostelium discoideum)
RHEA:33364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-mannitol 1-phosphate(in) + L-histidyl-[protein]
REACT:R-RNO-70333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KHK dimer phosphorylates Fru to Fru 1-P (Rattus norvegicus)
RHEA:16647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + hexadecanoate => H2O + hexadecanoyl-CoA
REACT:R-HSA-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Homo sapiens)
RHEA:25274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate
REACT:R-CFA-975139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Canis familiaris)
REACT:R-MMU-167429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex  binds GTP (Mus musculus)
REACT:R-CEL-8865320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX1 (Caenorhabditis elegans)
REACT:R-RNO-1295609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates SPRY2 on Y55 and Y227 (Rattus norvegicus)
REACT:R-GGA-8866327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDL translocates from SER lumen to extracellular region (Gallus gallus)
RHEA:64740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate
RHEA:22400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + H(+) + NADH
REACT:R-DME-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Drosophila melanogaster)
REACT:R-HSA-1299338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRESK (Homo sapiens)
REACT:R-GGA-190408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2b (Gallus gallus)
RHEA:69704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O => beta-D-galactose + N-hexadecanoylsphing-4-enine
RHEA:49227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]
RHEA:35828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-aminopropylagmatine => spermidine + urea
RHEA:62345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate => diphosphate + notoamide S
RHEA:46896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)
GO:0140772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
GO:0140772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-dependent peptidyl-lysine N6-palmitoyltransferase activity
REACT:R-HSA-9634391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds phosphorylated ERBB2 homodimer (Homo sapiens)
REACT:R-BTA-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Bos taurus)
REACT:R-RNO-8874080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates PTK2 (Rattus norvegicus)
RHEA:45535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine
RHEA:66136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + tyramine = CoA + H(+) + N-acetyltyramine
REACT:R-MMU-210420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx through voltage gated Ca2+ channels (Mus musculus)
RHEA:62004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)
REACT:R-RNO-1855197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)
REACT:R-DRE-2161951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)
REACT:R-XTR-9627078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP9 (Xenopus tropicalis)
REACT:R-MMU-177941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:GAB1 binds to phosphorylated EGFR (Mus musculus)
GO:0019966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1 binding
GO:0019966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-1 binding
RHEA:36666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA <=> (2S,5S)-5-carboxymethylproline + CO2 + CoA
RHEA:15958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-altronate => 2-dehydro-3-deoxy-D-gluconate + H2O
RHEA:53387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + NAD(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH
REACT:R-CEL-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Caenorhabditis elegans)
REACT:R-SSC-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Sus scrofa)
RHEA:31940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] => DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-167408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The high affinity receptor complex binds to G-protein (Danio rerio)
REACT:R-SPO-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Schizosaccharomyces pombe)
REACT:R-HSA-3229118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC37A4 does not exchange G6P and Pi across the ER membrane (Homo sapiens)
RHEA:61843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brassicasterol + UDP-alpha-D-glucose <=> brassicasterol 3-beta-D-glucoside + H(+) + UDP
REACT:R-HSA-202706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha4beta1 binds JAM2:JAM3 (Homo sapiens)
GO:0000773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLMT
GO:0000773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO:0000773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methyltransferase II
GO:0000773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylethanolamine methyltransferase I
GO:0000773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylmonomethylethanolamine methyltransferase activity
GO:0000773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospholipid methyltransferase activity
GO:0000773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidyl-N-monomethylethanolamine methyltransferase activity
GO:0000773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO:0000773	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidyl-N-methylethanolamine methyltransferase activity
REACT:R-HSA-561072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal uptake of organic cations (Homo sapiens)
REACT:R-SSC-5672969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF (Sus scrofa)
REACT:R-DME-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Drosophila melanogaster)
REACT:R-RNO-1297354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acrosin Cleavage (Rattus norvegicus)
GO:0106429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol dehydrogenase
REACT:R-BTA-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Bos taurus)
RHEA:31426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate
REACT:R-DRE-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Danio rerio)
REACT:R-DME-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Drosophila melanogaster)
GO:0062185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secalciferol 1-monooxygenase activity
GO:0062185	skos:prefLabel	"calcidiol 1-monooxygenase"
GO:0062185	skos:altLabel	"25-hydroxycholecalciferol 1-monooxygenase"
GO:0062185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]
GO:0062185	skos:altLabel	"25-hydroxyvitamin D-1 alpha hydroxylase"
GO:0062185	skos:altLabel	"25-OHD-1 alpha-hydroxylase"
GO:0062185	skos:altLabel	"25-hydroxyvitamin D3 1alpha-hydroxylase"
GO:0062185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]
GO:0062185	skos:altLabel	"25-hydroxycholecalciferol 1-hydroxylase"
GO:0062185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"calcidiol 1-monooxygenase"
RHEA:19549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"orsellinate-depside hydrolase"
RHEA:19549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + o-orsellinate depside = H(+) + 2 orsellinate
RHEA:19549	skos:prefLabel	"orsellinate-depside hydrolase"
RHEA:19549	skos:altLabel	"lecanorate hydrolase"
GO:0047550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoadipate reductase activity
GO:0047550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate reductase activity
GO:0047550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ketoadipate reductase activity
GO:0047550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxyadipate:NAD+ 2-oxidoreductase activity
REACT:R-HSA-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)
RHEA:52149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose => an aliphatic (Z)-desulfo-glucosinolate + UDP
REACT:R-DRE-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Danio rerio)
RHEA:27594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 5 diphosphate
RHEA:27594	skos:prefLabel	"all-trans-nonaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]"
RHEA:27594	skos:altLabel	"nonaprenyl diphosphate synthase"
RHEA:27594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-nonaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]"
RHEA:27594	skos:altLabel	"solanesyl diphosphate synthase"
RHEA:13861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + NAD(+) = D-xylono-1,5-lactone + H(+) + NADH
RHEA:26525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2-methylcitrate <=> 2-methyl-trans-aconitate + H2O
RHEA:72005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(out) + urate(in) => (S)-lactate(in) + urate(out)
RHEA:31284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + FADH2
REACT:R-RNO-6787677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUOM isomerises alpha-Fuc to beta-Fuc (Rattus norvegicus)
RHEA:24434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + oxalate => H2O + oxaloacetate
REACT:R-CEL-629588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Caenorhabditis elegans)
REACT:R-XTR-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Xenopus tropicalis)
REACT:R-HSA-6782286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 (Homo sapiens)
REACT:R-HSA-1912368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR302A microRNA binds 3'UTR of NOTCH4 mRNA (Homo sapiens)
RHEA:52426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-BTA-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Bos taurus)
EC:3.4.24.78	skos:altLabel	"spore protease"
EC:3.4.24.78	skos:altLabel	"germination proteinase"
EC:3.4.24.78	skos:altLabel	"germination protease"
EC:3.4.24.78	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GPR endopeptidase"
EC:3.4.24.78	skos:prefLabel	"GPR endopeptidase"
RHEA:37772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:53197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:39003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-MMU-5618331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC6 deacetylates microtubules (Mus musculus)
REACT:R-HSA-9604446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HES5 gene expression is stimulated by NOTCH4 (Homo sapiens)
REACT:R-RNO-8852331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 translocates to the nucleus (Rattus norvegicus)
REACT:R-DRE-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Danio rerio)
RHEA:33355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA
REACT:R-SSC-975902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Sus scrofa)
REACT:R-XTR-1250189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Xenopus tropicalis)
REACT:R-SSC-111289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)
REACT:R-SCE-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
RHEA:51558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine => (S)-glaucine + S-adenosyl-L-methionine
GO:0034010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SuyAB
GO:0034010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-sulfolactate = H(+) + pyruvate + sulfite
GO:0034010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfolactate sulfo-lyase activity
GO:0034010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-sulfolactate bisulfite-lyase (pyruvate-forming) activity
GO:0034010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2R)-sulfolactate sulfo-lyase"
GO:0034010	skos:altLabel	"sulfolactate sulfo-lyase"
GO:0034010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-sulfolactate bisulfite-lyase activity
GO:0034010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Suy
GO:0034010	skos:prefLabel	"(2R)-sulfolactate sulfo-lyase"
REACT:R-GGA-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Gallus gallus)
REACT:R-DRE-6814409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates PDCL (Danio rerio)
RHEA:53697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
RHEA:54679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> (+)-kolavenyl diphosphate
RHEA:62248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetaldehyde + H2O + NADP(+) = chloroacetate + 2 H(+) + NADPH
REACT:R-HSA-5649854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to oxidatively damaged AP site (Homo sapiens)
RHEA:38118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol <=> 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
RHEA:14819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-fumarylacetoacetate => 4-maleylacetoacetate
RHEA:68490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + tridecanal => (2R)-2-hydroperoxytetradecanoate + H(+)
REACT:R-RNO-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Rattus norvegicus)
GO:0018713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketopimelyl-CoA thiolase activity
REACT:R-CEL-198513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Caenorhabditis elegans)
REACT:R-SPO-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)
REACT:R-XTR-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Xenopus tropicalis)
REACT:R-DDI-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Dictyostelium discoideum)
REACT:R-HSA-5691512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEH hydrolyses NAc-Ser-protein (Homo sapiens)
REACT:R-GGA-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Gallus gallus)
GO:0102165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hexen-1-ol acetyltransferase activity
REACT:R-SSC-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Sus scrofa)
RHEA:34288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-dopa + O2 => 2 H2O + 2 L-dopaquinone
REACT:R-HSA-9618863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK binds activated calmodulin in the nucleus (Homo sapiens)
REACT:R-DRE-1638821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-B56 dephosphorylates centromeric cohesin (Danio rerio)
RHEA:65646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine => (4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA
RHEA:68371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP
REACT:R-DME-390929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1 and 5A receptors can bind serotonin (Drosophila melanogaster)
GO:0034877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isonicotinate dehydrogenase activity
RHEA:12488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosaminate ammonia-lyase"
RHEA:12488	skos:altLabel	"2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating)"
RHEA:12488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH4(+)
RHEA:12488	skos:prefLabel	"glucosaminate ammonia-lyase"
RHEA:12488	skos:altLabel	"aminodeoxygluconate dehydratase"
RHEA:12488	skos:altLabel	"D-glucosaminate dehydratase"
RHEA:12488	skos:altLabel	"D-glucosaminic acid dehydrase"
RHEA:12488	skos:altLabel	"2-amino-2-deoxy-D-gluconate ammonia-lyase"
RHEA:12488	skos:altLabel	"glucosaminic dehydrase"
RHEA:12488	skos:altLabel	"acetylenemonocarboxylic acid hydrase"
RHEA:12488	skos:altLabel	"aminodeoxygluconate ammonia-lyase"
REACT:R-SSC-8869425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA1A hydrolyses PS to 2-acyl LPS (Sus scrofa)
GO:0071860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proctolin receptor binding
RHEA:64325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + cholesterol => cholesteryl (11Z)-octadecenoate + CoA
RHEA:63650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-RNO-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Rattus norvegicus)
REACT:R-HSA-9020273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Homo sapiens)
REACT:R-SSC-164840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP and Pi bind to ATPase (Sus scrofa)
REACT:R-MMU-8866551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR binds components of the ERAD machinery for ubiquitination and degradation (Mus musculus)
REACT:R-CEL-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Caenorhabditis elegans)
REACT:R-RNO-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Rattus norvegicus)
RHEA:45984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)
REACT:R-RNO-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Rattus norvegicus)
RHEA:30327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:31165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + H2O => (3S)-hydroxyhexadecanoyl-CoA
RHEA:30753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + hexadecanoyl-CoA => ATP + CoA + hexadecanoate
REACT:R-HSA-9761841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2-dependent SLC7A11 expression (Homo sapiens)
REACT:R-HSA-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Homo sapiens)
REACT:R-BTA-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Bos taurus)
REACT:R-RNO-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Rattus norvegicus)
REACT:R-CFA-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Canis familiaris)
RHEA:59862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:63286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-MMU-2429719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCPH1 sequesters condensin II (Mus musculus)
REACT:R-MMU-9023633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)
RHEA:71825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodo-L-thyronine(in) => 3,3'-diiodo-L-thyronine(out)
REACT:R-HSA-428287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF2BP3 binds specific RNAs (Homo sapiens)
REACT:R-CFA-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Canis familiaris)
RHEA:22463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + NADP(+) <=> a 2,3-dehydroacyl-CoA + H(+) + NADPH
REACT:R-HSA-8961888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the CCNA1 gene promoter (Homo sapiens)
RHEA:52076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)
RHEA:54748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-firefly luciferin--CoA ligase"
RHEA:54748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + firefly L-luciferin = AMP + diphosphate + L-firefly luciferyl-CoA
RHEA:54748	skos:prefLabel	"L-firefly luciferin--CoA ligase"
REACT:R-RNO-3108203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO2,3 (Rattus norvegicus)
REACT:R-RNO-5336184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37L binds prosaposin (Rattus norvegicus)
REACT:R-BTA-8875591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK7 activates RAC1 (Bos taurus)
REACT:R-DME-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Drosophila melanogaster)
RHEA:30849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + CO2 + FADH2 => FAD + glutaryl-CoA + 2 H(+)
REACT:R-BTA-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Bos taurus)
REACT:R-HSA-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Homo sapiens)
RHEA:55281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + tetradecanoyl-CoA => 13-cis-retinyl tetradecanoate + CoA
RHEA:66502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:44699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine
RHEA:57986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside Rg3 + UDP-alpha-D-glucose
GO:0016837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-oxygen lyase activity, acting on polysaccharides
GO:0016837	skos:prefLabel	"Acting on polysaccharides"
GO:0016837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on polysaccharides"
REACT:R-GGA-1254251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds YAP1 (Gallus gallus)
RHEA:32417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2S,4R)-isodihydrocarveol + NAD(+)
REACT:R-MMU-5672958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from KSR1:MARK3 (Mus musculus)
REACT:R-GGA-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Gallus gallus)
REACT:R-CEL-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Caenorhabditis elegans)
REACT:R-MMU-3215385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Mus musculus)
RHEA:23492	skos:prefLabel	"UDP-glucosamine 4-epimerase"
RHEA:23492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-glucosamine 4-epimerase"
RHEA:23492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucosamine = UDP-alpha-D-galactosamine
REACT:R-SSC-176250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR-ATRIP to the RPA-ssDNA complex (Sus scrofa)
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	citrate lyase
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citridesmolase activity
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate aldolase activity
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate (pro-3S)-lyase activity
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate oxaloacetate-lyase activity
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citric aldolase activity
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citritase activity
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrase activity
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citratase activity
GO:0008815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate lyase activity
RHEA:36205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-RNO-8874718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA binds alpha-TOH (Rattus norvegicus)
REACT:R-SSC-8938815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 polyubiquitinates RRAGA (Sus scrofa)
REACT:R-SSC-351849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Etk (Sus scrofa)
GO:0036080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine nucleotide-sugar transmembrane transporter activity
REACT:R-SSC-391941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLT receptors can bind LTB4 (Sus scrofa)
REACT:R-GGA-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Gallus gallus)
REACT:R-XTR-5624492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK phosphorylates p21 RAF1 on S338 (Xenopus tropicalis)
RHEA:43743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexanoate <=> AMP + diphosphate + hexanoyl-CoA
REACT:R-SPO-196754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY transfers an adenylyl group from ATP to PPANT (Schizosaccharomyces pombe)
REACT:R-XTR-189208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-CFA-427656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-DDI-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Dictyostelium discoideum)
REACT:R-PFA-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Plasmodium falciparum)
REACT:R-BTA-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Bos taurus)
RHEA:15942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-acetyl-L-ornithine => acetate + L-ornithine
REACT:R-BTA-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)
REACT:R-CFA-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Canis familiaris)
RHEA:10748	skos:prefLabel	"carbonic anhydrase"
RHEA:10748	skos:altLabel	"carbonate hydro-lyase"
RHEA:10748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogencarbonate = CO2 + H2O
RHEA:10748	skos:altLabel	"carbonic dehydratase"
RHEA:10748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carbonic anhydrase"
RHEA:10748	skos:altLabel	"carbonate dehydratase"
REACT:R-GGA-5693539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of DNA and formation of Holliday structures following repair synthesis (Gallus gallus)
RHEA:14161	skos:altLabel	"E-2"
RHEA:14161	skos:prefLabel	"acireductone dioxygenase (Ni(2+)-requiring)"
RHEA:14161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
RHEA:14161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acireductone dioxygenase (Ni(2+)-requiring)"
RHEA:14161	skos:altLabel	"ARD"
RHEA:14161	skos:altLabel	"acireductone dioxygenase"
RHEA:14161	skos:altLabel	"2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase"
REACT:R-SSC-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Sus scrofa)
RHEA:50138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + ethanol + H(+) => ethyl (9Z)-octadecenoate + H2O
REACT:R-HSA-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Homo sapiens)
REACT:R-HSA-3159232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment Of HIV Virion Budding Machinery (Homo sapiens)
RHEA:50593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) => 15-oxoprostaglandin F1alpha + H(+) + NADPH
RHEA:36641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine
REACT:R-DDI-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Dictyostelium discoideum)
REACT:R-DME-9691621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5 binds C5 inhibitors (Drosophila melanogaster)
RHEA:58999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-carbaldehyde + O2 <=> H(+) + H2O2 + indole-3-carboxylate
REACT:R-HSA-5659755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC6A18 does not transport Gly from extracellular region to cytosol (Homo sapiens)
REACT:R-BTA-390593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Bos taurus)
RHEA:25648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,5R)-isomenthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH
GO:0034200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D,D-heptose 1,7-bisphosphate phosphatase activity
REACT:R-DME-1295599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 translocates to the plasma membrane (Drosophila melanogaster)
RHEA:65949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 => A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O
REACT:R-DME-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Drosophila melanogaster)
RHEA:42710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine => guanosine(46) in tRNA + S-adenosyl-L-methionine
RHEA:29967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine(in) + H(+)(in) = 2'-deoxyuridine(out) + H(+)(out)
RHEA:40774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rg1 + H2O <=> (20S)-ginsenoside F1 + D-glucose
RHEA:21739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3,6-diaminohexanoate <=> (3S,5S)-3,5-diaminohexanoate
GO:0015410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ABC-type Mn(2+) transporter
GO:0015410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	manganese-transporting ATPase activity
GO:0015410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type manganese transporter activity
GO:0015410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent manganese transmembrane transporter activity
GO:0015410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled manganese transmembrane transporter activity
GO:0015410	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	manganese transmembrane transporter activity, phosphorylative mechanism
GO:0015410	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	manganese ABC transporter
REACT:R-DRE-1855179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Danio rerio)
RHEA:10275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + ATP <=> a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-CFA-2160932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 binds phosphorylated PARD6A (Canis familiaris)
REACT:R-XTR-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Xenopus tropicalis)
REACT:R-DME-201603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of PKC theta (Drosophila melanogaster)
GO:0032407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MutSalpha complex binding
RHEA:57563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:59333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-hydroxy-gamma-carotene + A => 1'-hydroxytorulene + AH2
REACT:R-CFA-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Canis familiaris)
REACT:R-HSA-201622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of gelsolin (Homo sapiens)
REACT:R-DME-9769235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGED1 binds NPAS4 (Drosophila melanogaster)
REACT:R-HSA-5651654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)
REACT:R-SSC-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Sus scrofa)
REACT:R-CFA-77312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Canis familiaris)
REACT:R-CFA-1678843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein translation regulator 4EHP (Canis familiaris)
REACT:R-CEL-201640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Caenorhabditis elegans)
REACT:R-XTR-6804468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO2 (Xenopus tropicalis)
RHEA:23907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] <=> 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]
REACT:R-HSA-8961972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the RRM2 gene promoter (Homo sapiens)
RHEA:19313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)
RHEA:23690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hypoxanthine + NH4(+) => adenine + H(+) + H2O
REACT:R-GGA-419843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCR (Gallus gallus)
REACT:R-MMU-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Mus musculus)
REACT:R-CFA-174374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
RHEA:28533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XMP <=> phosphate + xanthosine
RHEA:66468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O = (17E)-cheilanthenediol
REACT:R-RNO-5694435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 and MIA3 load procollagen VII into COPII vesicles (Rattus norvegicus)
RHEA:32052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => adenosine 5'-tetraphosphate + AMP + 2 H(+)
REACT:R-SSC-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Sus scrofa)
RHEA:11449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pregnan-21-ol => H(+) + NADH + pregnan-21-al
REACT:R-XTR-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Xenopus tropicalis)
RHEA:16208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate
GO:0004359	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine aminohydrolase activity
GO:0004359	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutaminase activity
GO:0004359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaminase activity
GO:0004359	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminase I
GO:0004359	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamine amidohydrolase activity
REACT:R-MMU-9014424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the phagocytic vesicle membrane (Mus musculus)
RHEA:53921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[Fas-activated protein] => ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]
REACT:R-DRE-8878581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYRP1 oxidises DHICA to IQCA (Danio rerio)
REACT:R-HSA-507937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 dimers translocate to the nucleus (Homo sapiens)
RHEA:14088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA <=> 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate
REACT:R-DME-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Drosophila melanogaster)
RHEA:22747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-1791133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Sec31A (Homo sapiens)
RHEA:69020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + NADPH + O2 = H2O + N-hydroxy-L-aspartate + NADP(+)
REACT:R-MMU-2029457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIIA with IgG-coated Ag (Mus musculus)
RHEA:68587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-tryptophan(out) <=> ADP + H(+) + L-tryptophan(in) + phosphate
RHEA:41334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2
REACT:R-BTA-5654637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)
RHEA:29020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(in) + H(+)(in) => D-galactose(out) + H(+)(out)
REACT:R-GGA-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Gallus gallus)
REACT:R-HSA-69600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)
REACT:R-BTA-71275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + glycine => ornithine + guanidoacetate (Bos taurus)
REACT:R-DRE-8865667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPA hydrolyses sterol esters to sterols and fatty acids (Danio rerio)
REACT:R-XTR-1638032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Xenopus tropicalis)
RHEA:37902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 <=> 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate
RHEA:41532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine
RHEA:41532	skos:altLabel	"phenylalanine 3-hydroxylase"
RHEA:41532	skos:prefLabel	"phenylalanine 3-monooxygenase"
RHEA:41532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine 3-monooxygenase"
EC:7.1.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Catalysing the translocation of hydrons"
EC:7.1.-.-	skos:prefLabel	"Catalysing the translocation of hydrons"
RHEA:49082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O => dibenzothiophene 5-oxide + FMNH2 + O2
REACT:R-MMU-2569057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP3 binds TRIF to mediate necroptosis (Mus musculus)
RHEA:64592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base
RHEA:65898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H2O + kynurenate => glyoxylate + L-kynurenine
RHEA:44553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O => H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine
RHEA:68206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoyl-3-octadecanoylglycerol + CoA => 1,2-dihexanoylglycerol + octadecanoyl-CoA
REACT:R-HSA-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Homo sapiens)
REACT:R-DRE-193737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Danio rerio)
RHEA:62480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:34513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-HSA-8964241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta-gamma complex and PIP3 recruit BTK to membrane (Homo sapiens)
REACT:R-HSA-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Homo sapiens)
REACT:R-CFA-5683405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP5C dephosphorylates TP53BP1 (Canis familiaris)
RHEA:57435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] <=> 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
RHEA:42925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:22707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + ricinine <=> 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)
RHEA:10555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + O2 <=> 2-dehydro-D-glucose + H2O2
REACT:R-DME-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Drosophila melanogaster)
REACT:R-MMU-74736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)
REACT:R-DRE-111804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)
REACT:R-HSA-3000433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PML with SUMO3 (Homo sapiens)
REACT:R-HSA-9024723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 (Homo sapiens)
REACT:R-RNO-446077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP230 interacts with keretin K5/K14 (Rattus norvegicus)
REACT:R-SSC-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Sus scrofa)
REACT:R-XTR-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-BTA-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Bos taurus)
REACT:R-GGA-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Gallus gallus)
REACT:R-RNO-140842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n fibrin monomers -> fibrin multimer (Rattus norvegicus)
REACT:R-MMU-5649726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Mus musculus)
RHEA:14266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-amino-5-oxopentanoate => 5-aminolevulinate
REACT:R-MMU-8848776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates DOK1 (Mus musculus)
REACT:R-RNO-4827383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Rattus norvegicus)
RHEA:24070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexano-6-lactone + NADP(+) => cyclohexanone + H(+) + NADPH + O2
RHEA:64392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in)
REACT:R-DDI-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Dictyostelium discoideum)
RHEA:61080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-minovincinine + acetyl-CoA = (+)-echitovenine + CoA
REACT:R-HSA-8938201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYL9 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)
REACT:R-HSA-9015122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors bind Va:Xa (Homo sapiens)
REACT:R-RNO-417829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds ADP (Rattus norvegicus)
REACT:R-BTA-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Bos taurus)
GO:0016216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopenicillin N synthase activity
GO:0016216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopenicillin-N synthase activity
GO:0016216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopenicillin-N synthetase activity
GO:0016216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)
RHEA:45132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
REACT:R-HSA-5617446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXD1 mRNA is translated (Homo sapiens)
RHEA:52460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-BTA-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)
REACT:R-RNO-2022851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfer GlcNAc to the heparan chain (Rattus norvegicus)
RHEA:19210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	codeine + NADP(+) => codeinone + H(+) + NADPH
REACT:R-MMU-5695980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD10 dehydrogenates S-2MPDA-CoA (Mus musculus)
GO:0001532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-21 receptor activity
GO:0001532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-21 receptor activity
GO:0001532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-21R
REACT:R-DME-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Drosophila melanogaster)
REACT:R-SCE-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Saccharomyces cerevisiae)
REACT:R-MMU-2187401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 dephosphorylates SMAD2/3 (Mus musculus)
REACT:R-HSA-163320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of mTERF with the termination sequence (Homo sapiens)
RHEA:72465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein] => L-threonyl-[protein] + NAD(+)
REACT:R-HSA-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Homo sapiens)
RHEA:56868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diglucosylglycerate octanoyltransferase"
RHEA:56868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA
RHEA:56868	skos:prefLabel	"diglucosylglycerate octanoyltransferase"
RHEA:56868	skos:altLabel	"DGG octanoyltransferase"
RHEA:66391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + prostaglandin E2(in) <=> ADP + H(+) + phosphate + prostaglandin E2(out)
REACT:R-MTU-936747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cleavage of L-cysteine from carrier protein (Mycobacterium tuberculosis)
REACT:R-XTR-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Xenopus tropicalis)
REACT:R-HSA-198611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates IKKalpha (Homo sapiens)
GO:0019958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-X-C chemokine binding
REACT:R-SSC-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Sus scrofa)
REACT:R-BTA-2980720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 binds NEK6/NEK7 in the cytosol (Bos taurus)
REACT:R-RNO-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Rattus norvegicus)
REACT:R-XTR-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Xenopus tropicalis)
RHEA:18065	skos:altLabel	"phosphonate-transporting ATPase"
RHEA:18065	skos:prefLabel	"ABC-type phosphonate transporter"
RHEA:18065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate + phosphonate(in)
RHEA:18065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type phosphonate transporter"
RHEA:40736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb1 + 2 H2O => 2 D-glucose + gypenoside LXXV
REACT:R-DRE-2187332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic CMs translocate to extracellular region (Danio rerio)
REACT:R-SSC-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Sus scrofa)
RHEA:46426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:23918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + UDP-alpha-D-xylose => H(+) + UDP-alpha-D-glucuronate
RHEA:72686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate(out) <=> cholate(in)
REACT:R-HSA-5696490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:CLCF1 binds CNTRF (Homo sapiens)
REACT:R-MMU-8853965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Mus musculus)
REACT:R-CFA-9640237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Canis familiaris)
GO:0050122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylhexosamine oxidase activity
GO:0050122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-D-hexosamine oxidase activity
GO:0050122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity
GO:0050122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity
RHEA:45677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-HSA-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Homo sapiens)
RHEA:13936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + H2O <=> all-trans-retinol + H(+) + hexadecanoate
GO:0015083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aluminum ion transmembrane transporter activity
GO:0015083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aluminium ion transporter activity
GO:0015083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aluminum resistance permease activity
GO:0015083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aluminium resistance permease activity
REACT:R-DRE-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Danio rerio)
REACT:R-DRE-5693584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Danio rerio)
RHEA:52953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + UDP-alpha-D-glucuronate => lithocholoyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-BTA-114577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Bos taurus)
RHEA:60821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH => adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide
REACT:R-XTR-877269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS-1 and SOCS-3 binds to p-JAK2 (Xenopus tropicalis)
REACT:R-XTR-9726949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIR binds PTGIR agonists (Xenopus tropicalis)
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl phosphate phosphatase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Dol-P phosphatase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyisoprenyl phosphate phosphatase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol phosphate phosphatase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl monophosphate phosphatase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-phosphate phosphohydrolase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyprenylphosphate phosphatase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl pyrophosphate phosphatase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-phosphatase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dol-P-P phosphohydrolase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol monophosphatase activity
GO:0047873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol phosphatase activity
REACT:R-HSA-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Homo sapiens)
RHEA:53295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin <=> H(+) + N-carbamoyl-L-methionine
REACT:R-SSC-9796379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Sus scrofa)
RHEA:56592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a disubstituted aliphatic (S)-hydroxynitrile = a ketone + hydrogen cyanide
RHEA:44015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP]
REACT:R-BTA-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Bos taurus)
RHEA:52562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-D-erythronate => 2-dehydro-D-erythronate
GO:0047586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphoadenosine hydrolase activity
GO:0047586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-acylphosphoadenosine hydrolase activity
GO:0047586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-acylphosphoadenosine acylhydrolase activity
REACT:R-DME-168140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Drosophila melanogaster)
GO:0005214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of chitin-based cuticle
REACT:R-SSC-2213201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibres (Sus scrofa)
RHEA:61538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-5693012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF15 binds TNFRSF25 (Gallus gallus)
GO:0106377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-ATP hydrolase activity
GO:0106377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)
REACT:R-CFA-2730892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV to p-SLP-76 (Canis familiaris)
REACT:R-MMU-9724745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds aprotinin (Mus musculus)
GO:0016453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-acetyltransferase activity
REACT:R-MMU-6809264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Mus musculus)
REACT:R-CFA-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Canis familiaris)
REACT:R-MMU-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Mus musculus)
REACT:R-SPO-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Schizosaccharomyces pombe)
REACT:R-RNO-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Rattus norvegicus)
RHEA:53276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:38682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sphinganine(in) <=> ADP + H(+) + phosphate + sphinganine(out)
GO:0050386	skos:prefLabel	"ureidosuccinase"
GO:0050386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ureidosuccinase"
GO:0050386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ureidosuccinase activity
GO:0050386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-carbamoyl-L-aspartate = CO2 + L-aspartate + NH4(+)
GO:0050386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-carbamoyl-L-aspartate amidohydrolase activity
REACT:R-PFA-5654986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN binds monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)
RHEA:52336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + H(+) = a long-chain fatty acyl-AMP + diphosphate
RHEA:30816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + H2O => beta-nicotinamide D-riboside + phosphate
REACT:R-CFA-4086205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN (osteopontin) degradation by MMP3, MMP7 (Canis familiaris)
RHEA:53905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[tau protein] => ADP + H(+) + O-phospho-L-threonyl-[tau protein]
REACT:R-CFA-9714361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC activates endoplasmic reticulum effectors (Canis familiaris)
REACT:R-RNO-2022379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Rattus norvegicus)
REACT:R-CEL-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Caenorhabditis elegans)
GO:0140940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A methylase activity
GO:0140940	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H2A methylation
GO:0140940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A methyltransferase activity
REACT:R-HSA-8849435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 dephosphorylates PTK6 (Homo sapiens)
RHEA:22469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + 3 H2O => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate
RHEA:12568	skos:altLabel	"4-nitrophenol-2-hydroxylase"
RHEA:12568	skos:prefLabel	"4-nitrophenol 2-monooxygenase"
RHEA:12568	skos:altLabel	"4-nitrophenol hydroxylase"
RHEA:12568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + H(+) + NADH + O2 = 4-nitrocatechol + H2O + NAD(+)
RHEA:12568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-nitrophenol 2-monooxygenase"
RHEA:22032	skos:prefLabel	"oxalomalate lyase"
RHEA:22032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxalomalate lyase"
RHEA:22032	skos:altLabel	"3-oxalomalate glyoxylate-lyase"
RHEA:22032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxalomalate = glyoxylate + oxaloacetate
REACT:R-XTR-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Xenopus tropicalis)
REACT:R-RNO-9700149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds PLCG1 (Rattus norvegicus)
RHEA:68372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine + pyruvate = 2-oxosuccinamate + L-alanine
RHEA:48749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threitol + NAD(+) => D-erythrulose + H(+) + NADH
GO:0050631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corydaline synthase activity
GO:0050631	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity
RHEA:67687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid(in) + ATP + H2O <=> a long-chain fatty acid(out) + ADP + H(+) + phosphate
RHEA:43803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Xenopus tropicalis)
REACT:R-SCE-70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Saccharomyces cerevisiae)
REACT:R-RNO-8964246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in G alpha (12)-BTK complex is activated (Rattus norvegicus)
REACT:R-HSA-9670189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F8 variant does not bind the cell membrane (Homo sapiens)
REACT:R-BTA-209924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is decarboxylated to dopamine (Bos taurus)
REACT:R-CFA-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Canis familiaris)
RHEA:68285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + L-seryl-[protein] => CoA + O-hexanoyl-L-seryl-[protein]
REACT:R-DRE-5693148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDK phosphorylates BCKDH (Danio rerio)
REACT:R-RNO-2002466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of allysine by LOX (Rattus norvegicus)
RHEA:72065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate(in) + 2 Na(+)(in) => glycoursodeoxycholate(out) + 2 Na(+)(out)
REACT:R-DDI-2267372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Dictyostelium discoideum)
RHEA:37446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
RHEA:19699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + H(+) + hexadecanoate => 11-cis-retinyl hexadecanoate + H2O
GO:0050358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pseudotropine forming tropinone reductase activity
GO:0050358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tropinone reductase activity
GO:0050358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pseudotropine:NADP+ 3-oxidoreductase activity
GO:0050358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tropinone reductase II activity
GO:0050358	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tropinone (psi-tropine-forming) reductase activity
REACT:R-DME-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Drosophila melanogaster)
GO:0004341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucono-delta-lactonase activity
GO:0004341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gluconolactonase activity
GO:0004341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gulonolactonase activity
GO:0004341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldonolactonase activity
GO:0004341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucono-1,5-lactone lactonohydrolase activity
GO:0004341	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lactonase activity
RHEA:28619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutyronitrile + H(+) + NADPH + O2 => 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)
REACT:R-HSA-416683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA3E binds to PLXND1 (Homo sapiens)
REACT:R-HSA-450027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Homo sapiens)
REACT:R-DRE-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Danio rerio)
REACT:R-HSA-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Homo sapiens)
RHEA:50565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]
RHEA:10493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphocholine => choline + phosphate
RHEA:16432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
REACT:R-DRE-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Danio rerio)
RHEA:17528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biuret + H2O <=> NH4(+) + urea-1-carboxylate
REACT:R-XTR-6788867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3K phosphorylates ketosamines (Xenopus tropicalis)
REACT:R-CFA-9757706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Canis familiaris)
EC:3.4.23.30	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pycnoporopepsin"
EC:3.4.23.30	skos:altLabel	"proteinase Ia"
EC:3.4.23.30	skos:prefLabel	"pycnoporopepsin"
REACT:R-CFA-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Canis familiaris)
RHEA:23499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxypentanoate + acetyl-CoA <=> 5-hydroxy-pentanoyl-CoA + acetate
RHEA:28800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-prolinylglycine => glycine + L-proline
REACT:R-HSA-8941628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-GGA-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Gallus gallus)
REACT:R-DRE-1482816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Danio rerio)
GO:0005137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-5 receptor binding
GO:0005137	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-5 receptor ligand
GO:0005137	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-5
REACT:R-XTR-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Xenopus tropicalis)
REACT:R-MMU-5607002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor VIIIa (Mus musculus)
GO:0061604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdopterin-synthase sulfurtransferase activity
RHEA:55545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine
REACT:R-XTR-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)
RHEA:62933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-acetylcytidine => acetate + cytidine + H(+)
REACT:R-PFA-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Plasmodium falciparum)
REACT:R-HSA-4084507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminin-111 binds endostatin dimer (Homo sapiens)
REACT:R-DME-1254248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80:YAP1 complex to the nucleus (Drosophila melanogaster)
GO:0052899	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N(1)-acetylpolyamine oxidase activity
GO:0052899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine
GO:0052899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052899	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyamine oxidase activity
REACT:R-GGA-1227783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IKKs complex mediated by MEKK1 (Gallus gallus)
REACT:R-HSA-3928617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB2 binds KALRN (Homo sapiens)
RHEA:50965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(8) in tRNA + H(+) + H2O => NH4(+) + uridine(8) in tRNA
RHEA:11272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol
RHEA:11272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-2-hydroxyacid dehydrogenase (quinone)"
RHEA:11272	skos:altLabel	"(R)-2-hydroxy acid dehydrogenase"
RHEA:11272	skos:prefLabel	"D-2-hydroxyacid dehydrogenase (quinone)"
RHEA:11272	skos:altLabel	"D-lactate dehydrogenase"
REACT:R-HSA-193727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
RHEA:35379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
RHEA:67844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:20372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde + H2O + O2 <=> glycine betaine + H(+) + H2O2
RHEA:31071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonate semialdehyde + L-alanine = (S)-3-amino-2-methylpropanoate + pyruvate
REACT:R-HSA-1237038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Homo sapiens)
RHEA:19340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydroxylamine + 2 NAD(+) <=> 2 H(+) + hyponitrous acid + 2 NADH
RHEA:47099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate
RHEA:64993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine
REACT:R-SSC-6785821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS5,(SOCS1) bind IL4RA (Sus scrofa)
REACT:R-HSA-2426149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds the ELOVL6 promoter (Homo sapiens)
RHEA:28163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + GTP => CMP + GDP + H(+)
GO:0102307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin C 3''-o-methyltransferase activity
GO:0047246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity
GO:0047246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity
GO:0047246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity
GO:0047246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LMT activity
GO:0047246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity
GO:0047246	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity
REACT:R-DRE-5693578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDP1 and TDP2 process unligatable DSB ends (Danio rerio)
RHEA:36081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine
REACT:R-DME-5358336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB forms mixed disulphides with Hh precursors (Drosophila melanogaster)
RHEA:10418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-benzylsuccinate => fumarate + toluene
REACT:R-CFA-109338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Canis familiaris)
RHEA:57275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA
RHEA:30755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamate = ADP + carbamoyl phosphate
REACT:R-DRE-8944254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVI (Danio rerio)
RHEA:39272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z)-tetracosenoyl-CoA => (2E,15Z)-tetracosadienoyl-CoA + H2O
REACT:R-SSC-5635855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Sus scrofa)
RHEA:52673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate
RHEA:11036	skos:altLabel	"glycine betaine ABC transporter"
RHEA:11036	skos:prefLabel	"ABC-type quaternary amine transporter"
RHEA:11036	skos:altLabel	"quaternary-amine-transporting ATPase"
RHEA:11036	skos:altLabel	"quaternary-amine ABC transporter"
RHEA:11036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + quaternary ammonium(out) = ADP + H(+) + phosphate + quaternary ammonium(in)
RHEA:11036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type quaternary amine transporter"
RHEA:31752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-XTR-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Xenopus tropicalis)
RHEA:46569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-451900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RB binds JAK1 (Sus scrofa)
RHEA:24582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + phosphate => D-sorbitol 6-phosphate + H2O
REACT:R-SCE-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Saccharomyces cerevisiae)
RHEA:55467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Rattus norvegicus)
REACT:R-MMU-376123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM associates with Rac1-GTP:pPAK1 (Mus musculus)
GO:0102933	skos:prefLabel	"GDP-perosamine synthase"
GO:0102933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity
GO:0102933	skos:altLabel	"GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase"
GO:0102933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-perosamine synthase"
GO:0102933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + GDP-alpha-D-perosamine = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate
REACT:R-SCE-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Saccharomyces cerevisiae)
RHEA:18615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + A + formaldehyde + H2O => 4-methoxybenzoate + AH2 + O2
REACT:R-SSC-2395412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SYK (Sus scrofa)
REACT:R-RNO-420883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins act as GEFs for G alpha-t (Rattus norvegicus)
REACT:R-CEL-446391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the PINCH-ILK-parvin complex (Caenorhabditis elegans)
RHEA:11795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + propene <=> 1,2-epoxypropane + H2O + NAD(+)
RHEA:27717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H2O <=> guanosine + phosphate
REACT:R-MMU-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Mus musculus)
RHEA:32641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:59142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + staphyloferrin A => ATP + citrate + N(5)-[(S)-citryl]-D-ornithine
REACT:R-SSC-8852167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:Catecholamine binds ARRB1, ARRB2 (Sus scrofa)
RHEA:34647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + squalene = 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-9008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 phosphorylates RUNX2 (Danio rerio)
REACT:R-DME-5624948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF17 enters the cilium (Drosophila melanogaster)
RHEA:45962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Xenopus tropicalis)
REACT:R-BTA-2730872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Calcineurin (Bos taurus)
RHEA:12096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-substituted formamide deformylase"
RHEA:12096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-benzylformamide = benzylamine + formate
RHEA:12096	skos:prefLabel	"N-substituted formamide deformylase"
RHEA:32504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:65497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH => 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)
REACT:R-HSA-389491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two NPFF receptors can bind neuropeptide FF (Homo sapiens)
REACT:R-SSC-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Sus scrofa)
RHEA:30959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol
REACT:R-DRE-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Danio rerio)
EC:1.20.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a cytochrome as acceptor"
EC:1.20.2.-	skos:prefLabel	"With a cytochrome as acceptor"
REACT:R-HSA-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Homo sapiens)
GO:0042356	skos:altLabel	"GDP-4-keto-6-deoxy-D-mannose reductase"
GO:0042356	skos:altLabel	"guanosine diphosphate-4-keto-D-rhamnose reductase"
GO:0042356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-4-dehydro-D-rhamnose reductase"
GO:0042356	skos:prefLabel	"GDP-4-dehydro-D-rhamnose reductase"
GO:0042356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphate-4-keto-D-rhamnose reductase activity
GO:0042356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-4-keto-D-rhamnose reductase activity
GO:0042356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity
GO:0042356	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-4-keto-6-deoxy-D-mannose reductase activity
GO:0042356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-D-rhamnose reductase activity
GO:0042356	skos:altLabel	"GDP-4-keto-D-rhamnose reductase"
REACT:R-DME-178208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF2 (Drosophila melanogaster)
RHEA:66830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein]
RHEA:53418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + S-adenosyl-L-methionine
REACT:R-RNO-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Rattus norvegicus)
REACT:R-XTR-8987096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Xenopus tropicalis)
RHEA:15134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + NADH + NH4(+)
REACT:R-HSA-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
REACT:R-SSC-9656244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 binds DA (Sus scrofa)
REACT:R-GGA-1504213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Gallus gallus)
REACT:R-HSA-211461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF1A-dependent synthesis of the L isoform of PKLR protein (Homo sapiens)
RHEA:43269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GM2 + H(+) + UDP
REACT:R-RNO-9756138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)
REACT:R-HSA-210273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and NKp44 (Homo sapiens)
REACT:R-SCE-71735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Saccharomyces cerevisiae)
RHEA:69522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-D-galactosaminate => H2O + N-acetyl-D-galactosamino-1,5-lactone
RHEA:64958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP + 2 H(+) + 2 phosphate => dTTP + 2 H2O
RHEA:19924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 5-phosphate + NADP(+) <=> D-ribulose 5-phosphate + H(+) + NADPH
REACT:R-CFA-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
REACT:R-HSA-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)
REACT:R-GGA-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Gallus gallus)
RHEA:23278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + formaldehyde => 2-dehydropantoate
REACT:R-PFA-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)
REACT:R-SCE-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Saccharomyces cerevisiae)
RHEA:56835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) <=> 2,3,6-trichlorohydroquinone + 2 glutathione
RHEA:45861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-HSA-2168889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin-related Protein binds Hemoglobin (Homo sapiens)
RHEA:55226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:0036311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitin disaccharide deacetylase activity
GO:0036311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitin oligosaccharide amidohydrolase activity
GO:0036311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitobiose amidohydrolase activity
GO:0036311	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chitin oligosaccharide deacetylase activity
RHEA:34817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	curcumin + 2 H(+) + 2 NADPH => 2 NADP(+) + tetrahydrocurcumin
RHEA:11178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 1-phosphate + D-glucose => kojibiose + phosphate
RHEA:62607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate
RHEA:71667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(out) + succinate(in) = malonate(in) + succinate(out)
RHEA:65701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucuronic epimerase activity
GO:0050378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucuronate 4-epimerase activity
GO:0050378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-galacturonic acid 4-epimerase activity
GO:0050378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucuronic epimerase activity
GO:0050378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphospho-D-galacturonic acid
GO:0050378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galacturonate 4-epimerase activity
GO:0050378	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucuronate epimerase activity
GO:0050378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucuronate 4-epimerase activity
REACT:R-BTA-5423664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)
RHEA:43594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral => all-trans-zeaxanthin + O2
REACT:R-HSA-5577259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2 variant:MSH3-defective DNA mismatch repair (Homo sapiens)
RHEA:48929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide
REACT:R-RNO-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Rattus norvegicus)
GO:0030544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hsp70 protein binding
REACT:R-GGA-2426259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Gallus gallus)
RHEA:58351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate
REACT:R-XTR-109341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Xenopus tropicalis)
RHEA:50069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycoursodeoxycholate(in) + H2O => ADP + glycoursodeoxycholate(out) + H(+) + phosphate
RHEA:21816	skos:prefLabel	"D-amino-acid oxidase"
RHEA:21816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)
RHEA:21816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-amino-acid oxidase"
RHEA:21816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)
GO:0103000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity
RHEA:53654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-SSC-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Sus scrofa)
RHEA:11407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate <=> UDP-alpha-D-galacturonate
RHEA:72963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(out) + 2 Na(+)(out) = acetoacetate(in) + 2 Na(+)(in)
REACT:R-BTA-9645428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1 binds ADP-heptose (Bos taurus)
REACT:R-RNO-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Rattus norvegicus)
REACT:R-SSC-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
RHEA:42436	skos:prefLabel	"protein-N(pi)-phosphohistidine--L-ascorbate phosphotransferase"
RHEA:42436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--L-ascorbate phosphotransferase"
RHEA:42436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] = L-ascorbate 6-phosphate(in) + L-histidyl-[protein]
RHEA:42436	skos:altLabel	"L-ascorbate PTS permease"
REACT:R-CFA-164834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enzyme-bound ATP is released (Canis familiaris)
RHEA:32489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + 2 H(+) + phosphocholine => CDP-choline + H2O
RHEA:48133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl phosphate + H2O => (2E,6E)-farnesol + phosphate
RHEA:61044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-5218645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 binds p-Y397-PTK2 (Rattus norvegicus)
REACT:R-DRE-141351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAOX:FAD oxidises NASPN to SPM (Danio rerio)
REACT:R-DRE-217255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO1:FAD N-oxidises TAM (Danio rerio)
REACT:R-CFA-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Canis familiaris)
REACT:R-GGA-1299359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TALK (Gallus gallus)
REACT:R-HSA-174441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)
REACT:R-GGA-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Gallus gallus)
REACT:R-SSC-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Sus scrofa)
RHEA:67468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine
RHEA:58874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-HSA-74747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
RHEA:18596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate <=> hexadecanal + phosphoethanolamine
REACT:R-DRE-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Danio rerio)
RHEA:59729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-ethylmalonyl-CoA => (2S)-ethylmalonyl-CoA
REACT:R-MMU-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Mus musculus)
REACT:R-SSC-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Sus scrofa)
REACT:R-XTR-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Xenopus tropicalis)
REACT:R-SSC-936390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD mediated deubiquitination of DDX58 (RIG-I) (Sus scrofa)
REACT:R-DRE-5654640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)
RHEA:59742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + S-octadecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + octadecanoyl-CoA
REACT:R-DRE-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Danio rerio)
GO:0060182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apelin receptor activity
REACT:R-HSA-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Homo sapiens)
RHEA:17671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2
REACT:R-DRE-4086392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Danio rerio)
RHEA:42516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-gulono-1,4-lactone = H(+) + L-gulonate
REACT:R-DDI-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-SSC-983700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds the activated BCR (Sus scrofa)
REACT:R-GGA-110231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by MBD4 glycosylase (Gallus gallus)
RHEA:25840	skos:altLabel	"5DG isomerase"
RHEA:25840	skos:prefLabel	"5-deoxy-glucuronate isomerase"
RHEA:25840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate
RHEA:25840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-deoxy-glucuronate isomerase"
REACT:R-DRE-2129375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin cross-linking by lysyl oxidase (Danio rerio)
RHEA:18982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantolactone + NADP(+) => 2-dehydropantolactone + H(+) + NADPH
RHEA:34605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a fatty acyl-CoA
REACT:R-CFA-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Canis familiaris)
REACT:R-CEL-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:39292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA
REACT:R-CFA-176585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Canis familiaris)
RHEA:68345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP => 3',2'-cGAMP + 2 diphosphate
REACT:R-BTA-349637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spherical HDL and SR-BI receptor form a complex at the cell surface (Bos taurus)
RHEA:45898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+) => an N-acyl-sphingoid base + CDP-ethanolamine
REACT:R-DRE-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Danio rerio)
RHEA:65771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:55682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + H(+) + pyruvate => (2S)-2-amino-4-deoxychorismate
RHEA:67368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-glutamine = acetate + L-glutamine
REACT:R-MMU-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Mus musculus)
REACT:R-SSC-8858270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HILPDA binds lipid droplets (Sus scrofa)
GO:0050058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleate isomerase activity
GO:0050058	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleic acid isomerase activity
GO:0050058	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate delta12-cis-delta11-trans-isomerase activity
RHEA:65041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-419646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:Met (Homo sapiens)
REACT:R-DME-5672843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1S1 (PRAS40) binds mTORC1 (Drosophila melanogaster)
REACT:R-CFA-5625738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Canis familiaris)
RHEA:37048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-histidine(out) => H(+)(in) + L-histidine(in)
RHEA:53488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH = 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)
RHEA:52211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-8849428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 binds PTK6 (Danio rerio)
RHEA:57529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O => a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)
REACT:R-SSC-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Sus scrofa)
REACT:R-GGA-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Gallus gallus)
REACT:R-GGA-186798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binds to PDGF-beta receptors only (Gallus gallus)
REACT:R-RNO-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Rattus norvegicus)
RHEA:19850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) => ADP-D-ribose 2'-phosphate + H(+) + nicotinamide
RHEA:29076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(out) + 2 H(+)(in) + ubiquinone-8 => CO2(out) + H(+)(out) + ubiquinol-8
REACT:R-RNO-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Rattus norvegicus)
REACT:R-HSA-192123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates CHOL (Homo sapiens)
REACT:R-BTA-372697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binding to p130cas (Bos taurus)
REACT:R-DME-8867754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
REACT:R-RNO-5685953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates RBBP8 (Rattus norvegicus)
RHEA:51941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2S)-2-methylbutanal oxime => (1Z,2S)-2-methylbutanal oxime
GO:0005483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soluble NSF attachment protein activity
GO:0005483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAP
REACT:R-CFA-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Canis familiaris)
RHEA:38606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) <=> 2'-phospho-cyclic ADP-ribose + nicotinamide
RHEA:12803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[tau protein] => ATP + L-seryl-[tau protein]
REACT:R-DRE-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Danio rerio)
RHEA:17308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega),N(omega)-dimethyl-L-arginine <=> dimethylamine + L-citrulline
RHEA:59831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-inosyl-L-homocysteine <=> inosine + L-homocysteine
REACT:R-RNO-2730886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC by SYK kinase (Rattus norvegicus)
REACT:R-RNO-5672958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from KSR1:MARK3 (Rattus norvegicus)
RHEA:22109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine => 2-oxobutanoate + NH4(+)
REACT:R-CFA-500717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GRIK3 homomer (Canis familiaris)
RHEA:67402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allo-aromadendrene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:29016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(out) + sn-glycerol 3-phosphate(in) => phosphate(in) + sn-glycerol 3-phosphate(out)
REACT:R-XTR-5625959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Xenopus tropicalis)
REACT:R-MMU-5660660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p300 acetylates RELA subunit (Mus musculus)
RHEA:26282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-5A + H2O => acetaldehyde + Co-precorrin-5B + H(+)
RHEA:68549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + psoralen + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol
REACT:R-DDI-5218906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 phosphorylates MLKL (Dictyostelium discoideum)
REACT:R-HSA-9710254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME oligomerizes (Homo sapiens)
REACT:R-DRE-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Danio rerio)
REACT:R-CEL-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Caenorhabditis elegans)
RHEA:19272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-furoate + ATP + CoA <=> 2-furoyl-CoA + AMP + diphosphate
RHEA:27414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + codeine + O2 => CO2 + formaldehyde + morphine + succinate
REACT:R-CEL-9012036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Caenorhabditis elegans)
REACT:R-PFA-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Plasmodium falciparum)
RHEA:13792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)
REACT:R-DRE-2294580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 hyperphosphorylates Condensin II complex (Danio rerio)
REACT:R-HSA-1655827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of 7-Dehydrocholesterol Reductase (DHCR7) (Homo sapiens)
RHEA:51804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyhumulone + dimethylallyl diphosphate = diphosphate + H(+) + lupulone
GO:0033719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R)-hydroxycarboxylate-viologen-oxidoreductase activity
GO:0033719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity
GO:0033719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-acid reductase activity
GO:0033719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HVOR
GO:0033719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoacid reductase activity
RHEA:43137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine
REACT:R-MMU-5624956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds INPP5E (Mus musculus)
REACT:R-HSA-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Homo sapiens)
REACT:R-CEL-9618378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 binds the Nup107-Nup160 complex (Caenorhabditis elegans)
REACT:R-BTA-5362437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are bound by lectins (Bos taurus)
GO:0015267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	substrate-specific channel activity
GO:0015267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-type channel activity
GO:0015267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pore class transporter activity
GO:0015267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonselective channel activity
GO:0015267	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	channel-forming toxin activity
GO:0015267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	channel/pore class transporter activity
GO:0015267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix (Homo sapiens)
GO:0015267	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pore activity
GO:0015267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	channel activity
REACT:R-DDI-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Dictyostelium discoideum)
RHEA:29432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + phosphate => ADP + diphosphate
RHEA:28124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+) => ATP + di-trans,octa-cis-undecaprenol
RHEA:39582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O
RHEA:35731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + tetradecanoyl-CoA = 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA
REACT:R-RNO-5610725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TULP3 is required for GPR161 localization in the cilium (Rattus norvegicus)
REACT:R-HSA-5655466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Homo sapiens)
REACT:R-GGA-190065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TrkA receptor internalizes to endosomes (Gallus gallus)
REACT:R-MMU-6801762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A oligomerize to form a pore complex (Mus musculus)
REACT:R-HSA-9754554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-COV 7a translocates to the late endosome membrane (Homo sapiens)
GO:0050500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,3-galactosyl-N-acetylhexosamine phosphorylase activity
GO:0050500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity
GO:0050500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity
GO:0050500	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-galactopyranosyl-(1,3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity
REACT:R-BTA-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Bos taurus)
REACT:R-BTA-9021050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 oligomer binds ESRs (Bos taurus)
REACT:R-HSA-6784323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)
GO:0047196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	wax synthase activity
GO:0047196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-alcohol O-fatty-acyltransferase activity
GO:0047196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	wax ester synthase activity
GO:0047196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:long-chain-alcohol O-acyltransferase activity
GO:0047196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	wax-ester synthase activity
RHEA:42046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + globoside Globo-H (d18:1(4E)) + H(+) => GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E))
RHEA:56278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-L-prolyl-AMP + diphosphate => ATP + L-proline
RHEA:40047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate
REACT:R-HSA-5694487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A4GNT transfers GlcNAc to core 2 mucins (Homo sapiens)
REACT:R-CFA-5692283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)
RHEA:11227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 2 D-alanine <=> ADP + D-alanyl-D-alanine + H(+) + phosphate
REACT:R-RNO-8853252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2:C3d,C3dg,iC3b binds CD19:CD81 (Rattus norvegicus)
REACT:R-BTA-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Bos taurus)
REACT:R-DME-1296046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJs transport K+ from the extracellular region to cytosol (Drosophila melanogaster)
REACT:R-SSC-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Sus scrofa)
GO:0102689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity
REACT:R-DDI-9020255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Dictyostelium discoideum)
REACT:R-HSA-9706340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y-GRB10 binds PIK3R1 (Homo sapiens)
RHEA:45719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N,N-trimethylglycyl-CoA <=> CoA + glycine betaine + H(+)
REACT:R-XTR-6809325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Xenopus tropicalis)
REACT:R-GGA-443779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Linkage of L1 with treadmilling F-actin (Gallus gallus)
REACT:R-BTA-389354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Vav1 (Bos taurus)
REACT:R-RNO-70342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Rattus norvegicus)
REACT:R-HSA-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Homo sapiens)
GO:0043712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyisocaproate CoA transferase activity
GO:0043712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyisocaproate CoA-transferase activity
GO:0043712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisocaproate CoA-transferase activity
RHEA:17231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol
GO:0050470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine dehydrogenase activity
GO:0050470	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)
GO:0050470	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TMADh activity
REACT:R-SSC-112379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of elongation factors to form elongation complex (Sus scrofa)
RHEA:68672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CEL-199917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
RHEA:49960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 = 5,10-dihydrophenazine + CO2 + H2O2
RHEA:39421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH
RHEA:38505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + a fatty acid + H(+) => 1,3-diacyl-sn-glycerol + H2O
REACT:R-SSC-5696197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Sus scrofa)
REACT:R-RNO-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Rattus norvegicus)
RHEA:66360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O = (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)
GO:0035004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-activated PI3K generates PIP3 (Homo sapiens)
GO:0035004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoinositide 3-kinase activity
GO:0035004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol 3-kinase activity
REACT:R-SSC-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Sus scrofa)
REACT:R-BTA-9698170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Bos taurus)
REACT:R-HSA-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Homo sapiens)
REACT:R-MMU-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Mus musculus)
RHEA:71830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate(in) + H(+)(in) <=> arsenate(out) + H(+)(out)
RHEA:19353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate + H2O = cholate + glycine
RHEA:19353	skos:prefLabel	"choloylglycine hydrolase"
RHEA:19353	skos:altLabel	"bile salt hydrolase"
RHEA:19353	skos:altLabel	"glycocholase"
RHEA:19353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choloylglycine hydrolase"
REACT:R-MMU-5693574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Mus musculus)
RHEA:56012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)
REACT:R-GGA-352119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Gallus gallus)
RHEA:50182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2
REACT:R-HSA-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Homo sapiens)
RHEA:49034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-8981534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin dimer:KIRREL binds FYN (Sus scrofa)
REACT:R-DRE-5649801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Danio rerio)
REACT:R-HSA-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Homo sapiens)
REACT:R-GGA-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Gallus gallus)
REACT:R-CFA-5627275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOPC promotes translocation of CFTR to lysosomes (Canis familiaris)
GO:0008673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-2-oxo-D-gluconate kinase activity
GO:0008673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygluconokinase (phosphorylating)
GO:0008673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygluconate kinase activity
GO:0008673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxygluconokinase activity
GO:0008673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygluconokinase activity
GO:0008673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketodeoxygluconokinase activity
GO:0008673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-D-gluconic acid kinase activity
GO:0008673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KDG kinase activity
GO:0008673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity
REACT:R-MMU-9748979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Mus musculus)
GO:0106032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA pseudouridine synthase activity
RHEA:58061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfinoacetaldehyde + H2O => acetaldehyde + H(+) + sulfite
RHEA:41943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate <=> [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate
REACT:R-SPO-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)
RHEA:45706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapaldehyde + H(+) + NADPH => (E)-sinapyl alcohol + NADP(+)
REACT:R-HSA-2467798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTTG1 (Securin) sequesters ESPL1 (Separase) (Homo sapiens)
RHEA:39813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-1839094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)
REACT:R-DME-5635845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind CDC73 (Drosophila melanogaster)
REACT:R-GGA-374207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled estrogen receptor 1 binds estrogen non-classically (Gallus gallus)
RHEA:20620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate
RHEA:20021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + deoxyamidinoproclavaminate + O2 = amidinoproclavaminate + CO2 + succinate
REACT:R-HSA-75879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Homo sapiens)
REACT:R-BTA-8857692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA demethylases demethylate N6-methyladenosine RNA (Bos taurus)
RHEA:48966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O => 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2
RHEA:47367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dodecanoate ester + H2O <=> an aliphatic alcohol + dodecanoate + H(+)
REACT:R-DRE-350604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Agmatine + H2O <=> putrescine + urea (Danio rerio)
REACT:R-MMU-8851827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Mus musculus)
REACT:R-BTA-5610720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI3 (Bos taurus)
RHEA:48534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate => ganglioside GQ1c (d18:1(4E)) + H2O
RHEA:61466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine
GO:0016934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Homo sapiens)
GO:0016934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellularly glycine-gated chloride channel activity
GO:0016934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine-inhibited chloride channel activity
GO:0016934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular-glycine-gated chloride channel activity
GO:0016934	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycine receptor
REACT:R-GGA-5654165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR1 (Gallus gallus)
REACT:R-CFA-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Canis familiaris)
REACT:R-SSC-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Sus scrofa)
REACT:R-RNO-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Rattus norvegicus)
REACT:R-SSC-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Sus scrofa)
RHEA:62850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate
RHEA:17716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine
REACT:R-BTA-428609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type I Na+-coupled phosphate co-transport (Bos taurus)
RHEA:29297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galacturonate(in) + H(+)(in) => aldehydo-D-galacturonate(out) + H(+)(out)
REACT:R-BTA-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Bos taurus)
REACT:R-DRE-8851933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates GAB1 (Danio rerio)
RHEA:57328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]
REACT:R-MMU-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)
RHEA:14373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]
GO:0050072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M(7)G(5')pppN pyrophosphatase activity
GO:0050072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	m7G(5')pppN diphosphatase activity
GO:0050072	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	m7G(5')pppN pyrophosphatase activity
GO:0050072	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	decapase activity
GO:0050072	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity
GO:0043130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin binding
REACT:R-RNO-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Rattus norvegicus)
RHEA:22441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine => H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP
RHEA:20592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]
GO:0017081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Homo sapiens)
GO:0017081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride channel regulator activity
REACT:R-DRE-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Danio rerio)
RHEA:36512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA
REACT:R-MMU-9015111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors binds Xa (Mus musculus)
RHEA:63214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + methylglyoxal
REACT:R-GGA-418442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Gallus gallus)
REACT:R-RNO-5682826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM11 (Rattus norvegicus)
RHEA:49110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine
RHEA:38130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol <=> 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA
REACT:R-DDI-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Dictyostelium discoideum)
RHEA:20577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyaminophenol = aminohydroquinone
RHEA:20577	skos:altLabel	"3HAP mutase"
RHEA:20577	skos:prefLabel	"3-(hydroxyamino)phenol mutase"
RHEA:20577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-(hydroxyamino)phenol mutase"
RHEA:20577	skos:altLabel	"3-hydroxylaminophenol mutase"
EC:1.-.-.-	skos:prefLabel	"Oxidoreductases"
EC:1.-.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Oxidoreductases"
REACT:R-DRE-4084982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Danio rerio)
REACT:R-DRE-9731228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)
REACT:R-HSA-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Homo sapiens)
REACT:R-RNO-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Rattus norvegicus)
REACT:R-HSA-5218811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO binds CRK (Homo sapiens)
REACT:R-CFA-8987097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Canis familiaris)
RHEA:23448	skos:altLabel	"CMP-2-keto-3-deoxyoctulosonic acid synthetase"
RHEA:23448	skos:altLabel	"CMP-KDO synthetase"
RHEA:23448	skos:prefLabel	"3-deoxy-manno-octulosonate cytidylyltransferase"
RHEA:23448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-deoxy-manno-octulosonate cytidylyltransferase"
RHEA:23448	skos:altLabel	"CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase"
RHEA:23448	skos:altLabel	"CMP-3-deoxy-D-manno-octulosonate diphosphorylase"
RHEA:23448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate
RHEA:53463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate
EC:3.7.1.27	skos:prefLabel	"neryl diphosphate diphosphatase"
EC:3.7.1.27	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neryl diphosphate diphosphatase"
EC:3.7.1.27	skos:altLabel	"nerol synthase"
RHEA:66907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cannabinerolate <=> AH2 + cannabichromenate
REACT:R-MMU-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Mus musculus)
REACT:R-DME-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Drosophila melanogaster)
REACT:R-SSC-8944220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIII (Sus scrofa)
RHEA:17065	skos:prefLabel	"mevalonate kinase"
RHEA:17065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mevalonate kinase"
RHEA:17065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)
RHEA:37878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklanonate + S-adenosyl-L-methionine <=> methyl aklanonate + S-adenosyl-L-homocysteine
RHEA:10756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate, phosphate dikinase"
RHEA:10756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate
RHEA:10756	skos:altLabel	"pyruvate,phosphate dikinase"
RHEA:10756	skos:altLabel	"PPDK"
RHEA:10756	skos:prefLabel	"pyruvate, phosphate dikinase"
RHEA:10756	skos:altLabel	"pyruvate,orthophosphate dikinase"
REACT:R-HSA-9033961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Homo sapiens)
REACT:R-MMU-2130640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of clathrin coated vesicle by Ii (Mus musculus)
RHEA:44161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 6-phosphate + H2O => myo-inositol + phosphate
REACT:R-CFA-2160935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 ubiquitinates RHOA (Canis familiaris)
REACT:R-CFA-450257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Canis familiaris)
REACT:R-DDI-211874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2S1 4-hydroxylates atRA (Dictyostelium discoideum)
RHEA:35361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-15-methylhexadecenoyl-CoA + H2O => 3-hydroxyisoheptadecanoyl-CoA
RHEA:34509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-diacetyllegionaminate + phosphate => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate
RHEA:64306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenylpropan-1-one + L-alanine => 1-phenylpropylamine + pyruvate
REACT:R-CFA-74711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRS (Canis familiaris)
RHEA:19413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
RHEA:19413	skos:altLabel	"phenylalanine translase"
RHEA:19413	skos:prefLabel	"phenylalanine--tRNA ligase"
RHEA:19413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine--tRNA ligase"
RHEA:19413	skos:altLabel	"phenylalanyl-tRNA synthetase"
RHEA:44642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + ADP => a 2'-deoxyribonucleoside 5'-diphosphate + ATP
REACT:R-CEL-176646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Caenorhabditis elegans)
RHEA:19568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> diphosphate + sabinene hydrate
RHEA:27983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-carboxy-7-deazaguanine + ATP + NH4(+) => 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate
REACT:R-GGA-5684261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K8 is phosphorylated (Gallus gallus)
GO:0030249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanylate cyclase regulator activity
RHEA:53171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
RHEA:15473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose = flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP
RHEA:15473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase"
RHEA:15473	skos:altLabel	"1->2 UDP-rhamnosyltransferase"
RHEA:15473	skos:altLabel	"UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase"
RHEA:15473	skos:prefLabel	"flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase"
REACT:R-BTA-9756183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Bos taurus)
GO:0052877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a copper protein as acceptor"
GO:0052877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor
GO:0052877	skos:prefLabel	"With a copper protein as acceptor"
REACT:R-HSA-5625870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)
REACT:R-RNO-202248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma1 (Rattus norvegicus)
RHEA:65617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cholest-4-en-3-one + H2O => 25-hydroxycholest-4-en-3-one + AH2
RHEA:15882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[Fas-activated protein] => ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]
REACT:R-CEL-1254251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds YAP1 (Caenorhabditis elegans)
REACT:R-DRE-4341016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Danio rerio)
REACT:R-DME-420980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Drosophila melanogaster)
RHEA:15227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + dTDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + dTTP + H(+)
GO:0008914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine/arginine leucyltransferase"
GO:0008914	skos:altLabel	"L/F transferase"
GO:0008914	skos:prefLabel	"lysine/arginine leucyltransferase"
GO:0008914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucyltransferase activity
GO:0008914	skos:altLabel	"leucyl-tRNA--protein transferase"
GO:0008914	skos:altLabel	"leucyl/phenylalanyl-tRNA--protein transferase"
GO:0008914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-leucyl-tRNA:protein leucyltransferase activity
GO:0008914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucyl, phenylalanine-tRNA-protein transferase activity
GO:0008914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucyl-tRNA--protein transferase activity
GO:0008914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucyl-phenylalanine-transfer ribonucleate-protein transferase activity
GO:0008914	skos:altLabel	"leucyltransferase"
GO:0008914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucyl/phenylalanyl-tRNA--protein transferase activity
GO:0008914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L/F transferase activity
GO:0008914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity
REACT:R-XTR-5654428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates SHC1 (Xenopus tropicalis)
RHEA:17327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-succinylamino-6-oxoheptanedioate + CoA => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA
RHEA:48019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-5-nitrocatechol + NADH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite
RHEA:61616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-proline betaine + NADH + O2 = formaldehyde + H2O + N-methyl-L-proline + NAD(+)
REACT:R-CFA-9604767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 dimer autophosphorylates (Canis familiaris)
RHEA:38178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + hexadecanoyl-CoA <=> all-trans-retinyl hexadecanoate + CoA
RHEA:12584	skos:altLabel	"16alpha-dehydroxylase"
RHEA:12584	skos:altLabel	"hydroxyprogesterone dehydroxylase"
RHEA:12584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16alpha-hydroxyprogesterone dehydratase"
RHEA:12584	skos:altLabel	"16alpha-hydroxyprogesterone dehydroxylase"
RHEA:12584	skos:altLabel	"16-dehydroprogesterone hydratase"
RHEA:12584	skos:prefLabel	"16alpha-hydroxyprogesterone dehydratase"
RHEA:12584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyprogesterone = 16,17-didehydroprogesterone + H2O
RHEA:29352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zn(2+)(in) => Zn(2+)(out)
REACT:R-MMU-443418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b signaling involves c-Src (Mus musculus)
GO:0042500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic endopeptidase activity, intramembrane cleaving
REACT:R-MMU-3788725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C complex binds EHMT1:EHMT2 (Mus musculus)
REACT:R-CFA-2046095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Canis familiaris)
REACT:R-BTA-5654667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)
GO:0102932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pterocarpan reductase activity
REACT:R-DRE-8956676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TP73 (Danio rerio)
REACT:R-CFA-5654692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
REACT:R-RNO-420214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The adrenomedullin receptor can bind adrenomedullin and intermedin (Rattus norvegicus)
RHEA:39224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctacosanoyl-CoA => (2E)-octacosenoyl-CoA + H2O
REACT:R-CFA-8944262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type X (Canis familiaris)
REACT:R-GGA-201631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 3 (Gallus gallus)
REACT:R-SPO-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Schizosaccharomyces pombe)
RHEA:65446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexyl butanoate => butanoyl-CoA + hexan-1-ol
REACT:R-BTA-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Bos taurus)
REACT:R-DRE-5624953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL13B binds INPP5E (Danio rerio)
RHEA:69906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(out) + 2 Na(+)(out) <=> cytidine(in) + 2 Na(+)(in)
REACT:R-MMU-381262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPARG:RXRA heterodimer (ARF6 complex) (Mus musculus)
REACT:R-CFA-1433451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds to p-KIT (Canis familiaris)
REACT:R-MMU-9619756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2 binds ABCA1 (Mus musculus)
REACT:R-SSC-9751201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Sus scrofa)
RHEA:62048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
REACT:R-HSA-8932400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYC:MAX binds the CDC25A gene (Homo sapiens)
RHEA:63868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 = (2R,9Z)-2-hydroperoxyoctadecenoate
REACT:R-RNO-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Rattus norvegicus)
REACT:R-DRE-5323545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canonical WNT signaling through the atypical receptor RYK (Danio rerio)
REACT:R-HSA-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Homo sapiens)
REACT:R-SSC-205234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of GAB2 to p-KIT (Sus scrofa)
RHEA:58841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-209302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BSK kinase dissociates from CKA scaffolding protein (Drosophila melanogaster)
REACT:R-HSA-9654525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Homo sapiens)
REACT:R-DRE-5668545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK autophosphorylates on T559 (Danio rerio)
REACT:R-SSC-390846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2D3,4 bind to DA (Sus scrofa)
RHEA:50781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octanal => (2E)-octenal + H(+) + NADPH
RHEA:69679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-beta-D-glucoside + H2O = apigenin + beta-D-glucose
REACT:R-HSA-2187303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (Homo sapiens)
RHEA:24633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 3 NADP(+) + NH4(+) => 5 H(+) + 3 NADPH + nitrite
REACT:R-DRE-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Danio rerio)
REACT:R-RNO-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Rattus norvegicus)
RHEA:57105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)
RHEA:46183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoate + ATP + CoA <=> 2-methylbutanoyl-CoA + AMP + diphosphate
REACT:R-DDI-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
RHEA:30973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene => 7,7',9,9'-tetra-cis-lycopene
REACT:R-DRE-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Danio rerio)
REACT:R-HSA-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Homo sapiens)
RHEA:13871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + CO2 + NADH => NAD(+) + prephenate
RHEA:15374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	columbamine + S-adenosyl-L-methionine => H(+) + palmatine + S-adenosyl-L-homocysteine
RHEA:28366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:28366	skos:prefLabel	"lipopolysaccharide N-acetylmannosaminouronosyltransferase"
RHEA:28366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipopolysaccharide N-acetylmannosaminouronosyltransferase"
RHEA:63711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:54715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
REACT:R-DME-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Drosophila melanogaster)
REACT:R-GGA-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Gallus gallus)
REACT:R-GGA-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Gallus gallus)
RHEA:33326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-XTR-170153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Xenopus tropicalis)
REACT:R-DME-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Drosophila melanogaster)
RHEA:37292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-leucine => L-alanine + L-leucine
REACT:R-MMU-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)
RHEA:30401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SPO-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)
REACT:R-RNO-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Rattus norvegicus)
REACT:R-MMU-4641147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DACT1 binds DVL2 (Mus musculus)
RHEA:23602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxohexanoate + L-glutamate => 2-oxoglutarate + L-2-aminohexanoate
RHEA:51319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + glycine <=> H2O + N-(9Z-octadecenoyl)glycine
RHEA:64047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine
RHEA:56170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine
REACT:R-DRE-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Danio rerio)
GO:0046570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthioribulose-1-phosphate dehydratase activity
GO:0046570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]
GO:0046570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthioribulose 1-phosphate dehydratase activity
GO:0046570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity
GO:0046570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylthioribulose-1-phosphate 4-dehydratase activity
GO:0046570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-PMT-ribulose dehydratase activity
GO:0046570	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]
REACT:R-BTA-2065550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds Importin beta-1 (Bos taurus)
REACT:R-HSA-5610754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)
REACT:R-CFA-2022412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)
RHEA:37456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
GO:0055041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclopentanol:NADP+ oxidoreductase activity
GO:0055041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclopentanol:NAD+ oxidoreductase activity
GO:0055041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopentanol dehydrogenase activity
REACT:R-XTR-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Xenopus tropicalis)
RHEA:64757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-benzyl-L-cysteine => benzylthiol + NH4(+) + pyruvate
RHEA:53935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Danio rerio)
RHEA:68281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + pentanoyl-CoA => CoA + O-pentanoyl-L-seryl-[protein]
RHEA:60310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine
RHEA:47849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate
GO:0000824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,4,5,6-tetrakisphosphate 3-kinase activity
GO:0000824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol tetrakisphosphate 3-kinase activity
GO:0000824	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	IpmK
GO:0000824	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol polyphosphate multikinase activity
GO:0000824	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	EC:2.7.1.151
GO:0000824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol-tetrakisphosphate 3-kinase activity
REACT:R-BTA-9021600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-proteins dissociate from plasma-membrane estrogen receptors (Bos taurus)
REACT:R-HSA-4341072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RARA with SUMO2 (Homo sapiens)
RHEA:41110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate
REACT:R-SSC-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)
GO:0034028	skos:altLabel	"N(5)-carboxyaminoimidazole ribonucleotide synthetase"
GO:0034028	skos:prefLabel	"5-(carboxyamino)imidazole ribonucleotide synthase"
GO:0034028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity
GO:0034028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-CAIR synthetase activity
GO:0034028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(carboxyamino)imidazole ribonucleotide synthase activity
GO:0034028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-(carboxyamino)imidazole ribonucleotide synthase"
GO:0034028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate
GO:0034028	skos:altLabel	"N(5)-CAIR synthetase"
GO:0034028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-carboxyaminoimidazole ribonucleotide synthetase activity
GO:0034028	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PurK
RHEA:19303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine => histamine + S-adenosyl-L-methionine
REACT:R-GGA-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Gallus gallus)
RHEA:68236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out)
RHEA:41848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]
REACT:R-RNO-5689317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the pre-incision complex in GG-NER (Rattus norvegicus)
REACT:R-SPO-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Schizosaccharomyces pombe)
REACT:R-BTA-8853429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLDA1 binds AURKA (Bos taurus)
RHEA:33661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+) => H(+) + N-tetracosanoylsphinganine + NADPH + O2
RHEA:50467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH <=> 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)
GO:0103016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-specific 2-thiouridylase activity
RHEA:22054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H(+) + hydroxylamine => A + H2O + NH4(+)
RHEA:19726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + UDP-alpha-D-galacturonate => CO2 + UDP-beta-L-arabinopyranose
RHEA:66448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-pent-2-en-1-ol + NADP(+) = (E)-2-pentenal + H(+) + NADPH
GO:0102719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:eugenol-O-methyltransferase activity
REACT:R-XTR-176474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Xenopus tropicalis)
REACT:R-MMU-5694417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Mus musculus)
REACT:R-PFA-5685649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPAs translocate from ER membrane to extracellular region (Plasmodium falciparum)
GO:0047384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity
GO:0047384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity
GO:0047384	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	reductase phosphatase activity
GO:0047384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity
REACT:R-DRE-171087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR [endosome membrane] => LDLR [plasma membrane] (Danio rerio)
RHEA:20844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate
RHEA:20844	skos:prefLabel	"pyruvate carboxylase"
RHEA:20844	skos:altLabel	"pyruvic carboxylase"
RHEA:20844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate carboxylase"
REACT:R-SSC-5357445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 dimer disassociates (Sus scrofa)
REACT:R-DRE-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Danio rerio)
RHEA:35921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + kanamycin D + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose
REACT:R-RNO-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Rattus norvegicus)
REACT:R-HSA-9667657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBEA binds NICD1 (Homo sapiens)
REACT:R-DRE-3149518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRR reduces cob(II)alamin to meCbl (Danio rerio)
GO:0102398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity
REACT:R-BTA-6792445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPH, I hydrolyse PA to 2-acyl LPA (Bos taurus)
RHEA:38517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O
REACT:R-SSC-5340320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTP transports GSL from plasma membrane to ER membrane (Sus scrofa)
REACT:R-GGA-2168046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XII degradation by MMP12 (Gallus gallus)
RHEA:64008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine
REACT:R-HSA-1222411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxynitrite oxidizes Peptide-Methionine residues (Homo sapiens)
RHEA:71905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide => guanine + NAD(+)
RHEA:30255	skos:altLabel	"plant alternative oxidase"
RHEA:30255	skos:altLabel	"ubiquinol oxidase"
RHEA:30255	skos:prefLabel	"ubiquinol oxidase (non-electrogenic)"
RHEA:30255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinol + O2 = 2 a ubiquinone + 2 H2O
RHEA:30255	skos:altLabel	"cyanide-insensitive oxidase"
RHEA:30255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ubiquinol oxidase (non-electrogenic)"
RHEA:10066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 2-methylserine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O
GO:0019826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxygen sensor activity
REACT:R-DRE-174132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Cyclin B:Cdc2 (Danio rerio)
REACT:R-SSC-378978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Sus scrofa)
RHEA:51928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) = (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH
RHEA:51928	skos:prefLabel	"N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase"
RHEA:51928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase"
RHEA:67214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2 => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2
REACT:R-SPO-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Schizosaccharomyces pombe)
RHEA:12971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + H(+) + sn-glycerol 3-phosphate => a sn-glycero-3-phosphodiester + H2O
REACT:R-GGA-211224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with DFF45 (Gallus gallus)
REACT:R-GGA-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Gallus gallus)
RHEA:24050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + D-fructose => phosphate + sucrose
RHEA:12520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa = (E)-caffeate + NH4(+)
RHEA:56954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP + H(+) + phosphoenolpyruvate => CTP + pyruvate
RHEA:64257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + glycine => CoA + H(+) + N-dodecanoylglycine
REACT:R-HSA-3645780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 KD mutants do not phosphorylate TGFBR1 (Homo sapiens)
RHEA:20027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A3 O-beta-D-glucoside + H(+) + UDP => gibberellin A3 + UDP-alpha-D-glucose
REACT:R-MTU-879311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins (Mycobacterium tuberculosis)
REACT:R-DRE-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Danio rerio)
REACT:R-SCE-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Saccharomyces cerevisiae)
REACT:R-CFA-8956025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Canis familiaris)
REACT:R-HSA-373747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of nephrin by FYN (Homo sapiens)
REACT:R-DME-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Drosophila melanogaster)
RHEA:22401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androstan-3alpha,17beta-diol + NAD(+) => 17beta-hydroxyandrostanone + H(+) + NADH
RHEA:41188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate
RHEA:49996	skos:prefLabel	"cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]"
RHEA:49996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]"
RHEA:49996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:36438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate(in) <=> a 1,2-diacyl-sn-glycero-3-phosphate(out)
REACT:R-MMU-165708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated 4EBP1 from eIF4E (Mus musculus)
REACT:R-CFA-5635860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Canis familiaris)
RHEA:22962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Mus musculus)
REACT:R-MMU-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Mus musculus)
REACT:R-DME-189384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLVRA:Zn2+, BLVRB reduce BV to BIL (Drosophila melanogaster)
REACT:R-DME-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Drosophila melanogaster)
RHEA:60432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cannabigerolate = AH2 + cannabichromenate
GO:0004792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate sulfurtransferase activity
GO:0004792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate cyanide transsulfurase activity
GO:0004792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulphate sulphurtransferase activity
GO:0004792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate thiotransferase activity
GO:0004792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate:cyanide sulfurtransferase activity
GO:0004792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rhodanese activity
GO:0004792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rhodanase activity
REACT:R-RNO-2176475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Rattus norvegicus)
RHEA:45593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
RHEA:65963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + leukotriene C4(out) <=> ADP + H(+) + leukotriene C4(in) + phosphate
REACT:R-SPO-9606894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DAPP1 (p-BAM32) binds PLCG2 (Schizosaccharomyces pombe)
REACT:R-RNO-444527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR is a receptor for formyl peptides (Rattus norvegicus)
RHEA:19839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + H(+) + NADH => D-sorbitol 6-phosphate + NAD(+)
REACT:R-HSA-9023968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Homo sapiens)
RHEA:42442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + iminosuccinate + NADH => L-aspartate + NAD(+)
RHEA:62652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1
REACT:R-HSA-74947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MII:SAG dissociates to p-RHO and SAG (Homo sapiens)
RHEA:22761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cypridina luciferin + O2 => CO2 + hnu + oxidized Cypridina luciferin
REACT:R-CEL-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Caenorhabditis elegans)
REACT:R-DDI-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Dictyostelium discoideum)
REACT:R-RNO-165777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4B by activated S6K1 (Rattus norvegicus)
RHEA:29385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyinosine + phosphate => dIMP + H2O
REACT:R-HSA-8940070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses NAD+ (Homo sapiens)
REACT:R-DRE-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Danio rerio)
REACT:R-DME-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Drosophila melanogaster)
REACT:R-XTR-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Xenopus tropicalis)
REACT:R-BTA-375473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-MMU-8964271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in PIP3:BTK:G beta-gamma complex is activated (Mus musculus)
REACT:R-BTA-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Bos taurus)
RHEA:72858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + dADP(in) <=> ADP(in) + dADP(out)
RHEA:46666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH
REACT:R-XTR-1614654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Xenopus tropicalis)
RHEA:62859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-HSA-9757954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4BP1 binds IKBKG (Homo sapiens)
RHEA:48384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated fatty acid + H2O2 = a 3-hydroxy fatty acid + H2O
RHEA:42316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:42316	skos:altLabel	"OFOR"
RHEA:42316	skos:prefLabel	"2-oxoacid oxidoreductase (ferredoxin)"
RHEA:42316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoacid oxidoreductase (ferredoxin)"
RHEA:62965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)
RHEA:45764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate 4-semialdehyde + NAD(+) = 2 H(+) + L-aspartate + NADH
RHEA:70887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-serine(out) + Na(+)(out) = L-glutamine(out) + L-serine(in) + Na(+)(in)
RHEA:44663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)
RHEA:25376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxy-3-methyl fatty acyl-CoA => a 2-methyl-branched fatty aldehyde + formyl-CoA
REACT:R-HSA-2426157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the MVK promoter (Homo sapiens)
REACT:R-DME-5610758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Drosophila melanogaster)
REACT:R-CFA-376369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp2 associated secretory vesicle to plasma membrane transport (Canis familiaris)
REACT:R-BTA-8862090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Bos taurus)
REACT:R-CFA-9627106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) forms dimer (Canis familiaris)
REACT:R-SSC-373700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-9 binds DCC:DIP13alpha complex (Sus scrofa)
RHEA:11231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-flavan-4-ol + NADP(+) <=> (2S)-flavanone + H(+) + NADPH
RHEA:40166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + H2O + NADP(+) <=> (R)-glycerate + 2 H(+) + NADPH
RHEA:16948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)
REACT:R-MMU-139909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BMF to mitochondria (Mus musculus)
REACT:R-CFA-190258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c binds to FGF (Canis familiaris)
REACT:R-DDI-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Dictyostelium discoideum)
GO:0051744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-divinyl protochlorophyllide a 8-vinyl reductase activity
REACT:R-MMU-5250210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Mus musculus)
REACT:R-RNO-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Rattus norvegicus)
REACT:R-DRE-9728723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Danio rerio)
GO:0050532	skos:altLabel	"ComB phosphatase"
GO:0050532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-phospho-3-sulfolactate phosphohydrolase activity
GO:0050532	skos:altLabel	"(2R)-phosphosulfolactate phosphohydrolase"
GO:0050532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate
GO:0050532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-phosphosulfolactate phosphatase"
GO:0050532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phosphosulfolactate phosphatase activity
GO:0050532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phosphosulpholactate phosphatase activity
GO:0050532	skos:prefLabel	"2-phosphosulfolactate phosphatase"
GO:0050532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R)-phosphosulfolactate phosphohydrolase activity
GO:0050532	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ComB phosphatase activity
RHEA:67322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sch 210971 => (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate
REACT:R-CFA-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Canis familiaris)
RHEA:66016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + H2O2 = H2O + hypobromite
RHEA:63156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-docosanoyl-taurine = docosanoate + taurine
RHEA:21586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydroxyacetone phosphate + NADH => NAD(+) + propane-1,2-diol 1-phosphate
REACT:R-CFA-140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Canis familiaris)
REACT:R-SSC-202717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of CEACAMs (Sus scrofa)
RHEA:21505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin + aldehydo-D-ribose 5-phosphate => 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde
RHEA:61704	skos:prefLabel	"L-serine--[L-seryl-carrier protein] ligase"
RHEA:61704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-serine--[L-seryl-carrier protein] ligase"
RHEA:61704	skos:altLabel	"serine-activating enzyme"
RHEA:61704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-serine = AMP + diphosphate + L-seryl-[peptidyl-carrier protein]
RHEA:72046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + orotate(out) <=> L-glutamate(out) + orotate(in)
REACT:R-MMU-8948232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Mus musculus)
REACT:R-MMU-2993898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRK1/VRK2 phosphorylate BANF1 (Mus musculus)
REACT:R-RNO-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Rattus norvegicus)
RHEA:19653	skos:altLabel	"CDP-4-keto-6-deoxyglucose reductase"
RHEA:19653	skos:altLabel	"cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase"
RHEA:19653	skos:altLabel	"CDP-4-keto-deoxy-glucose reductase"
RHEA:19653	skos:altLabel	"CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system"
RHEA:19653	skos:prefLabel	"CDP-4-dehydro-6-deoxyglucose reductase"
RHEA:19653	skos:altLabel	"cytidine diphospho-4-keto-6-deoxy-D-glucose reductase"
RHEA:19653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH
RHEA:19653	skos:altLabel	"NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase"
RHEA:19653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH
RHEA:19653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-4-dehydro-6-deoxyglucose reductase"
REACT:R-BTA-3296244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUCNR1 binds SUCCA (Bos taurus)
REACT:R-SSC-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Sus scrofa)
REACT:R-MMU-445448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHIP binds Hedgehog (Mus musculus)
RHEA:31120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA => (2E)-2-methylbut-2-enoyl-CoA + H2O
RHEA:58374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H(+) + NADPH => (E)-oct-2-en-1-ol + NADP(+)
REACT:R-MMU-3266557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I cleaves iC3b (Mus musculus)
REACT:R-CFA-8851550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside diphosphates (Canis familiaris)
REACT:R-DRE-9021600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-proteins dissociate from plasma-membrane estrogen receptors (Danio rerio)
RHEA:12862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + H(+) + H2O => NH4(+) + xanthosine
REACT:R-RNO-5626699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK4 binds ODF2 in the centriole (Rattus norvegicus)
REACT:R-HSA-936897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)
RHEA:37626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(in) <=> L-lysine(out)
REACT:R-HSA-167087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Limited elongation of the HIV-1 transcript (Homo sapiens)
RHEA:21851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide <=> (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide
REACT:R-SSC-5674019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds KSR1:MARK3 (Sus scrofa)
REACT:R-DDI-936963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization (Dictyostelium discoideum)
RHEA:72332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
GO:0015550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galacturonate transmembrane transporter activity
RHEA:52299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-2314678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS1 (Danio rerio)
REACT:R-DRE-391942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP receptor can bind prostacyclin (Danio rerio)
RHEA:43904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol = all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:51545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose => D-xylulose
REACT:R-MMU-5694421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6 dephosphorylates SEC24 (Mus musculus)
RHEA:28102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + H2O = D-mannose + GDP + H(+)
REACT:R-DME-1013020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Drosophila melanogaster)
REACT:R-HSA-167282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)
REACT:R-HSA-9021480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter (Homo sapiens)
REACT:R-MMU-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Mus musculus)
REACT:R-XTR-9603987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Xenopus tropicalis)
RHEA:37761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA
GO:0032090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyrin domain binding
GO:0032090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAPIN domain binding
GO:0032090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAAD domain binding
GO:0018639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylene monooxygenase activity
RHEA:54519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycopalyl diphosphate <=> (13R)-manoyl oxide + diphosphate
REACT:R-HSA-9607342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FABP6 regulated by NR1H2,3 (Homo sapiens)
REACT:R-BTA-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
REACT:R-SSC-158925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Sus scrofa)
REACT:R-CEL-1605595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Caenorhabditis elegans)
EC:1.5.1.1	skos:prefLabel	"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]"
EC:1.5.1.1	skos:altLabel	"pyrroline-2-carboxylate reductase"
EC:1.5.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]"
GO:0050225	skos:prefLabel	"pseudouridine kinase"
GO:0050225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudouridine kinase"
GO:0050225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pseudouridine kinase (phosphorylating)
GO:0050225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine kinase activity
GO:0050225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pseudouridine = ADP + H(+) + psi-UMP
GO:0050225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:pseudouridine 5'-phosphotransferase activity
REACT:R-MMU-74712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of IRS-P from insulin receptor (Mus musculus)
RHEA:52567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-L-erythronate <=> 3-dehydro-L-erythronate
REACT:R-XTR-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Xenopus tropicalis)
GO:0018527	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexylamine:oxygen oxidoreductase (deaminating)
GO:0018527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexylamine oxidase activity
REACT:R-GGA-9708430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 (CRM1) binds to BACH1:Hemes (Gallus gallus)
RHEA:19679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9'-cis-neoxanthin + O2
REACT:R-MMU-204863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang2 (Mus musculus)
RHEA:16540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O <=> (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate
REACT:R-RNO-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Rattus norvegicus)
RHEA:26296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'S)-averufin + NADPH + O2 <=> 1'-hydroxyversicolorone + H2O + NADP(+)
REACT:R-HSA-5357479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AXL binds PI3K (Homo sapiens)
REACT:R-BTA-5628871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 promotes EP300-mediated acetylation of TP53 (Bos taurus)
REACT:R-MMU-9611277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds P2RY12 antagonists (Mus musculus)
RHEA:46879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate <=> [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)
REACT:R-CFA-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Canis familiaris)
REACT:R-DME-8849878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSD-95 binds NMDA receptor (Drosophila melanogaster)
RHEA:21285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + NAD(+) => all-trans-retinal + H(+) + NADH
REACT:R-BTA-2106615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of siRNA passenger strand (Bos taurus)
RHEA:19074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[I-kappa-B protein] => ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]
REACT:R-HSA-909726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 (Homo sapiens)
RHEA:15025	skos:altLabel	"XRS1"
RHEA:15025	skos:prefLabel	"7-methylxanthosine synthase"
RHEA:15025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-methylxanthosine synthase"
RHEA:15025	skos:altLabel	"XMT"
RHEA:15025	skos:altLabel	"xanthosine methyltransferase"
RHEA:15025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthosine = 7-methylxanthosine + S-adenosyl-L-homocysteine
RHEA:50352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH = 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]
REACT:R-MMU-379387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DA to form 3MT (Mus musculus)
RHEA:46025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + tetradecanoate => (3R)-hydroxytetradecanoate + H2O
REACT:R-GGA-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Gallus gallus)
REACT:R-RNO-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Rattus norvegicus)
REACT:R-MMU-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Mus musculus)
REACT:R-BTA-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Bos taurus)
RHEA:20713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-CoA + H(+) + L-alanine => (8S)-8-amino-7-oxononanoate + CO2 + CoA
REACT:R-HSA-9708866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-F2R binds vorapaxar (Homo sapiens)
REACT:R-MMU-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Mus musculus)
REACT:R-BTA-4332359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active calmodulin binds CAMK2 (Bos taurus)
RHEA:66442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	but-3-en-2-one + H(+) + NADPH => butan-2-one + NADP(+)
GO:0102284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-sphinganine reductase activity
REACT:R-HSA-8850539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)
REACT:R-DME-8953115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds to MGA:MAX (Drosophila melanogaster)
RHEA:22338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine + N,N-dimethylglycine => glycine betaine + L-homocysteine
RHEA:44940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)
GO:0050155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine/ornithine:2-oxoglutarate aminotransferase activity
GO:0050155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine(lysine) transaminase activity
GO:0050155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity
GO:0050155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine(lysine) aminotransferase activity
GO:0050155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine:2-oxoglutarate-aminotransferase activity
REACT:R-RNO-8875482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin to ubiquitinated MET (Rattus norvegicus)
REACT:R-GGA-5626316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Gallus gallus)
REACT:R-CFA-9006870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT phosphorylation (Canis familiaris)
REACT:R-MMU-6800794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 associates with CRADD (Mus musculus)
REACT:R-SSC-202237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)
REACT:R-HSA-9032478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)
REACT:R-CFA-201677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Canis familiaris)
RHEA:67770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-1483159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho is dephosphorylated to Cho by PHOSPHO1 (Xenopus tropicalis)
REACT:R-SSC-192157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)
REACT:R-DME-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Drosophila melanogaster)
RHEA:67641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dZMP => ADP + dZDP
REACT:R-DRE-8857577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 facilitates PTK6 autophosphorylation (Danio rerio)
RHEA:14267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate => (S)-4-amino-5-oxopentanoate
RHEA:41033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA
RHEA:44718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+) => A + all-trans-4,4'-diapolycopen-4-al + H2O
REACT:R-MMU-139893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Granzyme-B activates BID by cleavage (Mus musculus)
REACT:R-MMU-5692768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates KALRN (Mus musculus)
RHEA:30650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + CTP + H(+) <=> CDP-1L-myo-inositol + diphosphate
RHEA:22227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA <=> 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O
RHEA:13764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionine
REACT:R-CFA-2127257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Canis familiaris)
REACT:R-MMU-5638333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Mus musculus)
REACT:R-SSC-3149563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Sus scrofa)
RHEA:15830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16alpha-hydroxysteroid => a 16beta-hydroxysteroid
RHEA:32891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5S)-alpha-pinene + H(+) + NADH + O2 = alpha-pinene oxide + H2O + NAD(+)
RHEA:32891	skos:prefLabel	"alpha-pinene monooxygenase"
RHEA:32891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-pinene monooxygenase"
REACT:R-HSA-176116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of Chk1 (Homo sapiens)
REACT:R-SSC-5649883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB-mediated DNA strand displacement synthesis (Sus scrofa)
REACT:R-GGA-6793661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Gallus gallus)
RHEA:20945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + theobromine => caffeine + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Xenopus tropicalis)
RHEA:69757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-aminocinnamoyl-CoA + CO2 + H2O2 => (2-aminobenzyl)malonyl-CoA + H(+) + O2
GO:0033844	skos:altLabel	"porphyran sulfatase"
GO:0033844	skos:prefLabel	"galactose-6-sulfurylase"
GO:0033844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactose-6-sulfate:alkyltransferase (cyclizing) activity
GO:0033844	skos:altLabel	"galactose-6-sulfatase"
GO:0033844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactose-6-sulfurylase"
GO:0033844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose-6-sulfurylase activity
GO:0033844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	porphyran sulfatase activity
GO:0033844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose 6-sulfatase activity
GO:0033844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose-6-sulfatase activity
RHEA:21272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione + spermidine = ADP + glutathionylspermidine + H(+) + phosphate
RHEA:30244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 L-ascorbate + O2 => 2 H2O + 4 monodehydro-L-ascorbate radical
REACT:R-DME-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Drosophila melanogaster)
RHEA:45800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-demethylaclacinomycin T + AH2 + O2 = 10-decarboxymethylaclacinomycin T + A + CO2 + H2O
RHEA:27383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + H2O
REACT:R-RNO-5607043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa associates with cell membrane (Rattus norvegicus)
REACT:R-RNO-3000449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Rattus norvegicus)
REACT:R-CFA-444527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR is a receptor for formyl peptides (Canis familiaris)
REACT:R-MMU-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Mus musculus)
REACT:R-RNO-3296244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUCNR1 binds SUCCA (Rattus norvegicus)
RHEA:42010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-pregnane-3,20-dione + H(+) + NADH => 5alpha-pregnan-20beta-ol-3-one + NAD(+)
REACT:R-DME-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Drosophila melanogaster)
REACT:R-DME-5694487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A4GNT transfers GlcNAc to core 2 mucins (Drosophila melanogaster)
RHEA:24639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + NAD(+) <=> H(+) + NADH
REACT:R-BTA-561072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal uptake of organic cations (Bos taurus)
RHEA:45455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetradecanoylethanolamine <=> ethanolamine + tetradecanoate
EC:1.14.99.55	skos:altLabel	"LPMO"
EC:1.14.99.55	skos:prefLabel	"lytic starch monooxygenase"
EC:1.14.99.55	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lytic starch monooxygenase"
REACT:R-MMU-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Mus musculus)
REACT:R-HSA-6810899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGM1 and involucrin bind the plasma membrane (Homo sapiens)
REACT:R-GGA-372724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Gallus gallus)
RHEA:36256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O
RHEA:13994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-2-methylpropanoate + 2-oxoglutarate => 2-methyl-3-oxopropanoate + L-glutamate
RHEA:52753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isomaltose => beta-D-glucose + D-glucose
RHEA:48211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-DDI-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Dictyostelium discoideum)
REACT:R-XTR-9014296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GEFs activate RAC2 (Xenopus tropicalis)
RHEA:36362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a plastoquinone + 2 H2O + 4 hnu <=> 2 a plastoquinol + O2
RHEA:41001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-CFA-917693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESCRT Disassembly (Canis familiaris)
RHEA:69863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in mRNA + S-adenosyl-L-methionine = a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-378952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin is a heterodimer (Xenopus tropicalis)
REACT:R-HSA-9751051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSH cleaves AZA to 6MP (Homo sapiens)
REACT:R-DRE-419001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Danio rerio)
REACT:R-SSC-428941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y purinoceptor 1 activates MAP kinase p38 alpha (Sus scrofa)
RHEA:49079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene + FMNH2 + O2 <=> dibenzothiophene 5-oxide + FMN + H(+) + H2O
GO:0015200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylammonium transmembrane transporter activity
REACT:R-BTA-209868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
RHEA:61230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+) => H2O + L-histidine + O2
GO:0070653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-density lipoprotein receptor binding
GO:0070653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDL receptor binding
GO:0070653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-density lipoprotein particle receptor binding
RHEA:33068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine 1-phosphate + H2O => (4R)-hydroxysphinganine + phosphate
REACT:R-DME-199298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CREB1 (Drosophila melanogaster)
RHEA:51362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-leucine => H2O + N-(9Z-octadecenoyl)-L-leucine
REACT:R-HSA-9665408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (Homo sapiens)
RHEA:11433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside => 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine
RHEA:29751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(in) = acetoacetate(out)
REACT:R-CFA-77329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Canis familiaris)
RHEA:57942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 H2O + harderoheme III => Fe-coproporphyrin III + H(+) + H2O2
REACT:R-BTA-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Bos taurus)
REACT:R-XTR-8937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)
REACT:R-SSC-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Sus scrofa)
REACT:R-XTR-3322434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP dissociates from ub-TLE (Xenopus tropicalis)
RHEA:70455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2
GO:0061667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0061667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	URM1 ligase activity
GO:0015188	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	isoleucine/valine:sodium symporter activity
GO:0015188	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leucine/isoleucine/valine porter activity
GO:0015188	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	leucine/valine/isoleucine permease activity
GO:0015188	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-isoleucine transporter activity
GO:0015188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine transmembrane transporter activity
RHEA:18525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol + NADP(+) = 3-methylbutanal + H(+) + NADPH
REACT:R-CFA-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Canis familiaris)
RHEA:23390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7''-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B
REACT:R-SPO-2168079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL (GWL) phosphorylates ARPP19 (Schizosaccharomyces pombe)
GO:0047546	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)
GO:0047546	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxypyridine oxygenase activity
GO:0047546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxypyridine 5-monooxygenase activity
REACT:R-MMU-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Mus musculus)
GO:0102171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMNT synthase activity
REACT:R-RNO-8938913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF1 (Rattus norvegicus)
RHEA:60917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in mRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Gallus gallus)
REACT:R-DME-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Drosophila melanogaster)
REACT:R-HSA-913456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)
REACT:R-RNO-1236965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Export of peptide loaded MHC class I complex to PM (Rattus norvegicus)
REACT:R-DRE-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Danio rerio)
REACT:R-CFA-211164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO1A (Canis familiaris)
REACT:R-XTR-4086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO2,3 (Xenopus tropicalis)
RHEA:44471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine
RHEA:21926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxo-L-gulonate + H(+) + NADH => 3-dehydro-L-gulonate + NAD(+)
RHEA:46217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + progesterone => 3beta-hydroxypregn-4-ene-20-one + NADP(+)
REACT:R-SSC-2162226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Sus scrofa)
REACT:R-DRE-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Danio rerio)
RHEA:39809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoate(out) => octadecanoate(in)
REACT:R-HSA-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Homo sapiens)
REACT:R-SSC-9692809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the ER membrane (Sus scrofa)
RHEA:53234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => desmosterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-157937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD3 traffics to the nucleus (Homo sapiens)
GO:0050263	skos:altLabel	"nucleoside ribohydrolase"
GO:0050263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-ribosylpyrimidine ribohydrolase activity
GO:0050263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine nucleosidase activity
GO:0050263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-ribosylpyrimidine nucleosidase activity
GO:0050263	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleoside ribohydrolase activity
GO:0050263	skos:altLabel	"N-ribosylpyrimidine ribohydrolase"
GO:0050263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribosylpyrimidine nucleosidase"
GO:0050263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RihB
GO:0050263	skos:altLabel	"pyrimidine nucleosidase"
GO:0050263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosylpyrimidine nucleosidase activity
GO:0050263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	YeiK
GO:0050263	skos:altLabel	"N-ribosylpyrimidine nucleosidase"
GO:0050263	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine-nucleoside ribohydrolase activity
GO:0050263	skos:prefLabel	"ribosylpyrimidine nucleosidase"
RHEA:37142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
RHEA:40818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
RHEA:21267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + glycolate <=> AH2 + glyoxylate
REACT:R-HSA-418852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of UNC5B (Homo sapiens)
RHEA:69106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-kynurenine
RHEA:51982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O => an L-N,N-dihydroxypolyhomomethionine + H(+)
RHEA:71501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in)
REACT:R-XTR-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Xenopus tropicalis)
RHEA:36021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-DME-266204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HMGB1/HMGB2 with chromatin (Drosophila melanogaster)
REACT:R-XTR-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Xenopus tropicalis)
RHEA:17296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + precorrin-3A <=> H2O + NAD(+) + precorrin-3B
REACT:R-SSC-174741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Sus scrofa)
REACT:R-SPO-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Schizosaccharomyces pombe)
REACT:R-SPO-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Schizosaccharomyces pombe)
REACT:R-HSA-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)
REACT:R-SSC-9646679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded proteins bind vimentin to form aggresome (Sus scrofa)
RHEA:67652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dADP + H2O = 2'-deoxyadenosine + diphosphate
RHEA:52745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclobis-(1->3)-alpha-D-isomaltosyl + H2O => alpha-isomaltosyl-(1->3)-isomaltose
REACT:R-GGA-2467798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTTG1 (Securin) sequesters ESPL1 (Separase) (Gallus gallus)
REACT:R-SSC-205075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JNK phosphorylates BIM, BAD and other targets (Sus scrofa)
RHEA:62696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 4 tellimagrandin II = 2 cornusiin E + 2 H2O
RHEA:69988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) => (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH
REACT:R-HSA-111751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
GO:0080130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine:alpha-ketoglutarate aminotransferase activity
GO:0080130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine:2-oxoglutarate aminotransferase activity
RHEA:70873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(out) + L-valine(in) + Na(+)(in) => L-glutamine(in) + L-valine(out) + Na(+)(out)
RHEA:50594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin F1alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+)
RHEA:24553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH
GO:0004823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucine-tRNA ligase activity
GO:0004823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucyl-transfer RNA synthetase activity
GO:0004823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine-tRNA synthetase activity
GO:0004823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-leucine:tRNALeu ligase (AMP-forming)
GO:0004823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine translase activity
GO:0004823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucyl-transfer ribonucleic acid synthetase activity
GO:0004823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucyl-tRNA synthetase activity
GO:0004823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucyl-transfer ribonucleate synthetase activity
REACT:R-MMU-9611721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1-agonists bind ADRB1 (Mus musculus)
REACT:R-HSA-9709396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO translocates from cytosol to extracellular region (Homo sapiens)
RHEA:50809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin J2 => prostaglandin J2-S-(S)-glutathione
RHEA:49324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R,6S)-5,6-epoxi-capsanthin = all-trans-capsorubin
REACT:R-MMU-4088141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PPP2R2A dephosphorylates FOXM1 (Mus musculus)
REACT:R-BTA-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Bos taurus)
REACT:R-DRE-114671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vWF binds to collagen (Danio rerio)
REACT:R-MMU-2161651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGE2 is converted to PGF2a by CBR1 (Mus musculus)
RHEA:33951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribostamycin + UDP-N-acetyl-alpha-D-glucosamine = 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP
RHEA:33951	skos:prefLabel	"UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase"
RHEA:33951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase"
RHEA:14979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-cis,cis-muconate => 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate
RHEA:38208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Bos taurus)
REACT:R-CFA-5651723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Canis familiaris)
REACT:R-CEL-8851933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates GAB1 (Caenorhabditis elegans)
REACT:R-HSA-2426156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the PMVK promoter (Homo sapiens)
RHEA:18899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-thyroxine => 3,3',5'-triiodo-L-thyronine + A + H(+) + iodide
GO:0015138	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dicarboxylate (succinate/fumarate/malate) antiporter activity
GO:0015138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate transmembrane transporter activity
REACT:R-MMU-193641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKK-beta is recruited (Mus musculus)
GO:0102356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoitalicene synthase activity
REACT:R-BTA-9679775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT binds COMT Inhibitors (Bos taurus)
RHEA:37790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-9620197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8:Substrate binds LAMP2a (Homo sapiens)
RHEA:29395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UTP = diphosphate + H(+) + UMP
REACT:R-HSA-9605644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Homo sapiens)
RHEA:27636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-didehydro-D-gluconate + H(+) + NADPH => 5-dehydro-D-gluconate + NADP(+)
RHEA:48386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-hydroxy fatty acid + H2O => a 2,3-saturated fatty acid + H2O2
RHEA:55128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-5-methylhexanoyl-[ACP] = (2E)-5-methylhexenoyl-[ACP] + H2O
GO:0140851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K14 ubiquitin ligase activity
GO:0140851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone ubiquitin ligase activity (H3-K14 specific)
GO:0140851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K14 ubiquitin ligase activity
REACT:R-XTR-110250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenoadenine by MPG glycosylase (Xenopus tropicalis)
REACT:R-XTR-374337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apelin receptor binds to apelin (Xenopus tropicalis)
REACT:R-CFA-3321883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSL acetylates histone H4 (Canis familiaris)
RHEA:14438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)
REACT:R-BTA-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Bos taurus)
REACT:R-CEL-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)
REACT:R-DRE-158721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Danio rerio)
REACT:R-PFA-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Plasmodium falciparum)
REACT:R-HSA-997326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Homo sapiens)
RHEA:61226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuccinamate + H2O2 + NH4(+) => H2O + L-asparagine + O2
REACT:R-HSA-844610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)
REACT:R-CEL-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Caenorhabditis elegans)
REACT:R-RNO-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Rattus norvegicus)
REACT:R-SCE-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Saccharomyces cerevisiae)
RHEA:33872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + H2O => glyoxylate + NH4(+) + urea
GO:0032422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine-rich negative regulatory element binding
GO:0032422	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PNR element binding
REACT:R-MMU-2160874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses (HA)50 (Mus musculus)
REACT:R-SSC-191072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Cx43 (Sus scrofa)
RHEA:24294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-L-glutamate => acetyl-CoA + L-glutamate
REACT:R-HSA-6804379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds TTC5 (Homo sapiens)
REACT:R-DRE-5691381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYSM1 deubiquitinates Histone H2A (Danio rerio)
REACT:R-DRE-8876615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB13 GEFs exchange GTP for GDP on RAB13 (Danio rerio)
RHEA:12848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O <=> [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate
REACT:R-CEL-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Caenorhabditis elegans)
REACT:R-BTA-6791219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Bos taurus)
REACT:R-XTR-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Xenopus tropicalis)
REACT:R-SCE-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Saccharomyces cerevisiae)
REACT:R-DRE-9612501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates CREB1 (Danio rerio)
REACT:R-MMU-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Mus musculus)
REACT:R-BTA-5693967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K754-GLDC dimer decarboxylates Gly (Bos taurus)
REACT:R-DRE-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Danio rerio)
REACT:R-RNO-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Rattus norvegicus)
RHEA:68289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptanoyl-CoA + L-seryl-[protein] => CoA + O-heptanoyl-L-seryl-[protein]
RHEA:18824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + choline <=> acetylcholine + CoA
RHEA:71546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethyl-dUMP in DNA + ATP <=> 5-phosphomethyl-dUMP in DNA + ADP + H(+)
RHEA:54440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4S)-2,3-dehydroflavan-3,4-diol + H(+) = a 4-H-anthocyanidin with a 3-hydroxy group + H2O
GO:0102942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dimethoxyphenol O-methyltransferase activity
REACT:R-BTA-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Bos taurus)
REACT:R-BTA-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)
REACT:R-PFA-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Plasmodium falciparum)
REACT:R-RNO-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Rattus norvegicus)
EC:3.4.11.16	skos:altLabel	"aminopeptidase W"
EC:3.4.11.16	skos:altLabel	"X-Trp aminopeptidase"
EC:3.4.11.16	skos:altLabel	"aminopeptidase X-Trp"
EC:3.4.11.16	skos:prefLabel	"Xaa-Trp aminopeptidase"
EC:3.4.11.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Xaa-Trp aminopeptidase"
REACT:R-HSA-8985900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Homo sapiens)
RHEA:35409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-methoxyisoflavan-2',4,7-triol => H2O + medicarpin
REACT:R-CFA-170844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 is cleaved by FURIN (Canis familiaris)
REACT:R-DDI-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)
REACT:R-GGA-8941312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Gallus gallus)
REACT:R-GGA-4719448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO3 (Gallus gallus)
RHEA:64735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate
REACT:R-CFA-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Canis familiaris)
REACT:R-DRE-389632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Danio rerio)
RHEA:69565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine => 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O
REACT:R-DRE-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Danio rerio)
REACT:R-DRE-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)
REACT:R-PFA-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Plasmodium falciparum)
RHEA:53873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + D-ribose 5-phosphate + H(+) => CDP-D-ribose + diphosphate
RHEA:49452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O = 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol
RHEA:49452	skos:prefLabel	"sulfoquinovosidase"
RHEA:49452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfoquinovosidase"
REACT:R-HSA-432956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP230 is recruited to the hemidesmosome (Homo sapiens)
RHEA:21972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-1 + S-adenosyl-L-methionine = precorrin-2 + S-adenosyl-L-homocysteine
RHEA:51632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Canis familiaris)
REACT:R-DDI-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)
RHEA:27979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + H2O => alpha-D-mannose 1-phosphate + GMP + 2 H(+)
REACT:R-RNO-169270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Rattus norvegicus)
REACT:R-DME-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Drosophila melanogaster)
REACT:R-XTR-1602377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Xenopus tropicalis)
REACT:R-XTR-428909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-protein  G13 (Xenopus tropicalis)
REACT:R-HSA-380294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of C-Nap-1 from centrosomes (Homo sapiens)
REACT:R-DME-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Drosophila melanogaster)
RHEA:17119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(5)-methyl-L-glutamine + phosphate => ATP + L-glutamate + methylamine
RHEA:25553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate => diphosphate + stemar-13-ene
REACT:R-DRE-8871226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA2 (Danio rerio)
REACT:R-SSC-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Sus scrofa)
RHEA:38692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)
REACT:R-RNO-83677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4 deamination of cytidine (Rattus norvegicus)
RHEA:21033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronate acceptor + UDP-alpha-D-glucuronate => acceptor beta-D-glucuronoside + H(+) + UDP
RHEA:32719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:57113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:44221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxypentadecanoate + ATP + CoA => 15-hydroxypentadecanoyl-CoA + AMP + diphosphate
REACT:R-HSA-2424482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)
REACT:R-BTA-5610726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The IFT-A complex recruits TULP3 (Bos taurus)
REACT:R-BTA-3858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL recruits RAC (Bos taurus)
REACT:R-DME-416929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PGF2a (Drosophila melanogaster)
REACT:R-SSC-8951966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates RUNX3 (Sus scrofa)
REACT:R-XTR-209840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two DITs combine to form thyroxine (Xenopus tropicalis)
RHEA:69513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-galactosamine + O2 => H(+) + H2O2 + N-acetyl-D-galactosaminate
RHEA:64916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate
GO:0015228	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	coenzyme A transporter activity
GO:0015228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme A transmembrane transporter activity
RHEA:66237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IC-asc-C9-CoA + O2 => H2O2 + IC-asc-DeltaC9-CoA
GO:0008875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gluconate dehydrogenase activity
RHEA:49969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 => H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]
RHEA:65313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]
RHEA:23317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + 2-oxoglutarate + O2 => 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil
GO:0015069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine:inosamine-P-amidinotransferase activity
GO:0015069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity
GO:0015069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine:inosamine phosphate amidinotransferase activity
GO:0015069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosamine-phosphate amidinotransferase activity
GO:0015069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosamine-P amidinotransferase activity
GO:0015069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inosamine-4-phosphate amidinotransferase activity
RHEA:30308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine
REACT:R-DDI-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Dictyostelium discoideum)
RHEA:64966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + 2 H(+) + 2 phosphate => dUTP + 2 H2O
RHEA:47445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(7Z-hexadecenoyl)-CoA + CoA => (5Z)-tetradecenoyl-CoA + acetyl-CoA
REACT:R-BTA-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
GO:0047152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity
GO:0047152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity
GO:0047152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity
GO:0047152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MT1
GO:0047152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MtaB
GO:0047152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol-corrinoid protein Co-methyltransferase
GO:0047152	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methyltransferase 1
GO:0047152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MT 1
GO:0047152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol:corrinoid methyltransferase activity
GO:0047152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methanol cobalamin methyltransferase activity
RHEA:10997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanal oxime + S-adenosyl-L-methionine => 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Xenopus tropicalis)
RHEA:16735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + orcinol => H(+) + orsellinate
REACT:R-XTR-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Xenopus tropicalis)
REACT:R-MMU-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Mus musculus)
RHEA:61724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-glucoside + NAD(+) = a 3-dehydro-D-glucoside + H(+) + NADH
RHEA:27555	skos:prefLabel	"hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]"
RHEA:27555	skos:altLabel	"(all-trans)-hexaprenyl-diphosphate synthase"
RHEA:27555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 2 diphosphate
RHEA:27555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]"
REACT:R-HSA-9665700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants (Homo sapiens)
RHEA:69150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NH4(+) + spermine monoaldehyde => H2O + O2 + spermine
RHEA:54499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate <=> diphosphate + ent-atiserene
RHEA:33957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIBOA beta-D-glucoside + H(+) + UDP => DIBOA + UDP-alpha-D-glucose
REACT:R-GGA-8982640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Gallus gallus)
REACT:R-RNO-8851900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1-2 bound to MET recruits GRB2:SOS1 (Rattus norvegicus)
REACT:R-BTA-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Bos taurus)
RHEA:28886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-threonine(in) <=> H(+)(out) + L-threonine(out)
RHEA:24401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UMP => ADP + UDP
REACT:R-XTR-6809309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR6 binds MTMR9 (Xenopus tropicalis)
REACT:R-DRE-77613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR2 homodimer to dsRNA duplex (Danio rerio)
RHEA:15819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NH4(+) + pyridoxal 5'-phosphate => H2O + O2 + pyridoxamine 5'-phosphate
REACT:R-CEL-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Caenorhabditis elegans)
REACT:R-SSC-3785711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Telomere shortening during replicative exhaustion (Sus scrofa)
GO:0050099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methylglutamate dehydrogenase activity
GO:0050099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)
GO:0050099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)
GO:0050099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylglutamate dehydrogenase activity
RHEA:39105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + sitosterol(out) => ATP + H2O + sitosterol(in)
RHEA:43777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine(in) => an N-(acyl)-sphingosylphosphocholine(out)
REACT:R-RNO-199456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN dephosphorylates PIP3 (Rattus norvegicus)
REACT:R-BTA-110251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of hypoxanthine by MPG glycosylase (Bos taurus)
REACT:R-BTA-1855198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
RHEA:71899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide
REACT:R-HSA-1497883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)
REACT:R-SSC-110375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Sus scrofa)
REACT:R-BTA-2466068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at chromosomal arms (Bos taurus)
RHEA:13322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3,3-dimethylmalate + NAD(+) => 3-methyl-2-oxobutanoate + CO2 + NADH
REACT:R-CFA-166220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion diffuses laterally to UCP (Canis familiaris)
RHEA:33012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:41174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O <=> 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)
RHEA:35671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-5'-oxoaverantin + H(+) = (1'S,5'S)-averufin + H2O
RHEA:35671	skos:altLabel	"OAVN cyclase"
RHEA:35671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5'-oxoaverantin cyclase"
RHEA:35671	skos:prefLabel	"5'-oxoaverantin cyclase"
RHEA:54518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-manoyl oxide + diphosphate => 8-hydroxycopalyl diphosphate
RHEA:17655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
RHEA:45608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine
REACT:R-MMU-5653936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Ragulator complex (Mus musculus)
REACT:R-DRE-4088281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endorepellin binds KDR (VEGFR2) (Danio rerio)
RHEA:41455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-1-naphthoate + H(+) + NADPH + O2 <=> 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)
REACT:R-CFA-110308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 inserts dCMP opposite to AP sites in DNA (Canis familiaris)
REACT:R-HSA-6802916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)
REACT:R-MMU-1483096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA is dephosphorylated to ETA by PHOSPHO1 (Mus musculus)
GO:0009001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine acetyltransferase activity
GO:0009001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:L-serine O-acetyltransferase activity
GO:0009001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine O-acetyltransferase activity
GO:0009001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine transacetylase activity
GO:0009001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SATase activity
GO:0009001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-serine acetyltransferase activity
REACT:R-XTR-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Xenopus tropicalis)
GO:0052619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-1:gamma-L-glutamate ligase activity
RHEA:26265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroabietadienal + H2O + NADP(+) = dehydroabietate + 2 H(+) + NADPH
REACT:R-HSA-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Homo sapiens)
GO:0042293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hub1 activating enzyme activity
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole glycerol phosphate hydrolase activity
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tryptophan synthase alpha subunit activity
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TSA
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-glycerol phosphate lyase activity
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole synthase activity
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IGL
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleglycerolphosphate aldolase activity
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BX1
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tryptophan synthase alpha activity
GO:0033984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-glycerol-phosphate lyase activity
REACT:R-GGA-5687121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPKAPK5 phosphorylates HSPB1 (Gallus gallus)
RHEA:50476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthraniloyl-CoA + L-cysteinyl-[PqsD protein] = CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]
REACT:R-BTA-418176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB2 binds MAPKs, SRC-1 (Bos taurus)
REACT:R-DME-2730872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Calcineurin (Drosophila melanogaster)
REACT:R-HSA-8869575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A in complex with DEK binds the APOE gene promoter (Homo sapiens)
RHEA:23926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP + diphosphate => pppGp(2'-5')A
RHEA:35883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:33585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
REACT:R-HSA-380316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of NuMA with microtubules (Homo sapiens)
RHEA:54857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + octan-3-one => ethyl hexanoate + H2O + NADP(+)
GO:0004526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase P
GO:0004526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease P activity
GO:0004526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA 5' leader endonuclease activity
REACT:R-RNO-8985594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYO9B inactivates RHOA (Rattus norvegicus)
REACT:R-RNO-1362416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Frataxin binds iron (Rattus norvegicus)
RHEA:55028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine = an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine
GO:0031704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APJ receptor binding
GO:0031704	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	apelin receptor ligand
GO:0031704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apelin receptor binding
REACT:R-DRE-419002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Danio rerio)
REACT:R-DRE-8875902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC45A3 transports Glc from extracellular region to cytosol (Danio rerio)
RHEA:40883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2
REACT:R-CFA-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Canis familiaris)
REACT:R-SCE-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Saccharomyces cerevisiae)
RHEA:42377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate
REACT:R-SPO-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Schizosaccharomyces pombe)
GO:0015145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monosaccharide transmembrane transporter activity
RHEA:53275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-L-gluconate <=> keto-D-tagaturonate
REACT:R-HSA-9729307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein is SUMOylated (Homo sapiens)
RHEA:34454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-beta-L-talose <=> dTDP-beta-L-rhamnose
RHEA:48726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => aurachin B + H(+) + H2O
REACT:R-BTA-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Bos taurus)
RHEA:17425	skos:altLabel	"pyruvate:NADP(+) oxidoreductase"
RHEA:17425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate dehydrogenase (NADP(+))"
RHEA:17425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NADP(+) + pyruvate = acetyl-CoA + CO2 + NADPH
RHEA:17425	skos:prefLabel	"pyruvate dehydrogenase (NADP(+))"
REACT:R-DRE-2730872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Calcineurin (Danio rerio)
RHEA:17142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + oxaloacetate => glyoxylate + L-aspartate
RHEA:61236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionine + O2 = 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)
GO:0008521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA transmembrane transporter activity
GO:0008521	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA transporter activity
RHEA:45263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracosanoate(out) <=> tetracosanoate(in)
REACT:R-SSC-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Sus scrofa)
RHEA:71123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + ATP + H(+) + 2 malonyl-CoA = AMP + 2 CO2 + 2 CoA + diphosphate + hispidin
RHEA:50136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (9Z)-octadecenoate + H2O = (9Z)-octadecenoate + ethanol + H(+)
RHEA:15357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = demethyllactenocin + dTDP + H(+)
RHEA:15357	skos:prefLabel	"O-mycaminosyltylonolide 6-deoxyallosyltransferase"
RHEA:15357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-mycaminosyltylonolide 6-deoxyallosyltransferase"
RHEA:30972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,7',9,9'-tetra-cis-lycopene => all-trans-lycopene
GO:1905773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxy-2'-deoxyguanosine DNA binding
REACT:R-XTR-163217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Xenopus tropicalis)
RHEA:23674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate + a quinol => a quinone + L-quinate
REACT:R-CFA-192157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
RHEA:30634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate <=> beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:21013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
REACT:R-DRE-4420107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHC-transforming protein 2 (Danio rerio)
REACT:R-BTA-373705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of DCC (Bos taurus)
RHEA:50865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + AH2 + O2 => 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
GO:0016738	skos:prefLabel	"With dinitrogen as acceptor"
GO:0016738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor
GO:0016738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With dinitrogen as acceptor"
REACT:R-CEL-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Caenorhabditis elegans)
REACT:R-HSA-1678981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR9 processing at neutral pH (Homo sapiens)
REACT:R-BTA-192051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7A1 7-hydroxylates CHOL (Bos taurus)
REACT:R-RNO-2730856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Rattus norvegicus)
RHEA:45125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acarbose + ATP => acarbose 7(IV)-phosphate + ADP + H(+)
GO:0008866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannonic dehydrogenase activity
GO:0008866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannonate oxidoreductase activity
GO:0008866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructuronate reductase activity
GO:0008866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannonate:NAD+ 5-oxidoreductase activity
GO:0008866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannonate:NAD oxidoreductase activity
GO:0008866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannonate oxidoreductase activity
GO:0008866	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannonate dehydrogenase activity
REACT:R-RNO-448702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-1 active tetramer formation (Rattus norvegicus)
REACT:R-XTR-265426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Tenascin (Xenopus tropicalis)
RHEA:30026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate
RHEA:23726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxate + H(+) + H2O2 => H2O + O2 + pyridoxal
REACT:R-MMU-8873794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCTP binds PC (Mus musculus)
REACT:R-MMU-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Mus musculus)
REACT:R-SPO-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Schizosaccharomyces pombe)
RHEA:72806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + N(omega)-methyl-L-arginine(in) <=> L-arginine(in) + N(omega)-methyl-L-arginine(out)
RHEA:60385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin + H2O => N-(2,3-dihydroxybenzoyl)-L-serine trimer
RHEA:63709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-8939706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) polyubiquitinates RUNX2 (Canis familiaris)
RHEA:19276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate <=> N-acetylneuraminate + phosphate
RHEA:27818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NAD(+) = 2-dehydro-L-idonate + H(+) + NADH
GO:0003729	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	base pairing with mRNA
GO:0003729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA binding
REACT:R-RNO-193065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Rattus norvegicus)
RHEA:45077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:12478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + L-glutamate => H2O + N-formyl-L-glutamate
GO:0047771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-5-carboxymethylhydantoin amidohydrolase activity
GO:0047771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydantoin hydrolase activity
GO:0047771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxymethylhydantoinase activity
GO:0102504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolinidin 5-O-glucosyltransferase activity
REACT:R-CFA-198955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR complex interacts with peptide antigen-presenting MHC Class I (Canis familiaris)
RHEA:40139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
REACT:R-CEL-6810474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Caenorhabditis elegans)
RHEA:53986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O
RHEA:15069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-devinyl-3-(1-hydroxyethyl)chlorophyllide a = chlorophyllide a + H2O
REACT:R-GGA-2029271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
REACT:R-BTA-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Bos taurus)
REACT:R-MMU-351877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 2 (Mus musculus)
REACT:R-BTA-5634729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Bos taurus)
REACT:R-HSA-212356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL-NICD coactivator complex (Homo sapiens)
RHEA:17840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-D-arabinitol 1-phosphate + H2O <=> 2-carboxy-D-arabinitol + phosphate
GO:0070546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine aminotransferase activity
GO:0050533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phytase activity
GO:0050533	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol-hexakisphosphate 5-phosphohydrolase activity
RHEA:25635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + syringetin => laricitrin + S-adenosyl-L-methionine
RHEA:25556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stemod-13(17)-ene synthase"
RHEA:25556	skos:prefLabel	"stemod-13(17)-ene synthase"
RHEA:25556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate = diphosphate + stemod-13(17)-ene
RHEA:25556	skos:altLabel	"stemodene synthase"
REACT:R-RNO-71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)
REACT:R-CFA-418576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 1:Gq complex (Canis familiaris)
RHEA:13424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate <=> an N-acylneuraminate 9-phosphate + phosphate
REACT:R-SSC-2002460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB binds Collagen chains (Sus scrofa)
REACT:R-RNO-209738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 binds GC (Rattus norvegicus)
REACT:R-BTA-9757706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Bos taurus)
REACT:R-MMU-174171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A with the APC/C (Mus musculus)
REACT:R-DRE-75095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIE to the growing preinitiation complex (Danio rerio)
REACT:R-MMU-8854303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D11 binds RAB6 (Mus musculus)
GO:0140536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear receptor corepressor activity
GO:0140536	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nuclear corepressor activity
RHEA:31525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + ethene + H2O => 2-oxoglutarate + 2 H(+) + O2
REACT:R-HSA-190260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b binds to FGF (Homo sapiens)
REACT:R-CFA-8944230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Canis familiaris)
RHEA:34226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxypseudooxynicotine + A + H2O <=> 2,6-dihydroxypseudooxynicotine + AH2
RHEA:61193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
GO:0036332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	placental growth factor-activated receptor activity
GO:0036332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PlGF-activated receptor activity
GO:0036332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	placental growth factor receptor activity
GO:0036332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PlGF receptor activity
RHEA:67328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione = trichosetin
REACT:R-XTR-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Xenopus tropicalis)
REACT:R-MMU-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Mus musculus)
GO:0102265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-dihydrouridine47 synthase activity
REACT:R-HSA-5621354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Homo sapiens)
RHEA:41814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-[ACP] + NADP(+) => (2E)-butenoyl-[ACP] + H(+) + NADPH
RHEA:36703	skos:altLabel	"carbapenam-3-carboxylate ligase"
RHEA:36703	skos:prefLabel	"carbapenam-3-carboxylate synthase"
RHEA:36703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carbapenam-3-carboxylate synthase"
RHEA:36703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,5S)-5-carboxymethylproline + ATP = (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)
REACT:R-HSA-2471670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RDH12 does not reduce atRAL to atROL (Homo sapiens)
REACT:R-HSA-8857549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)
REACT:R-SSC-8937369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAD2 binds ESR1 (Sus scrofa)
RHEA:51169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-adrenaline + H2O + O2 => (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine
RHEA:33275	skos:prefLabel	"sn-1-specific diacylglycerol lipase"
RHEA:33275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)
RHEA:33275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sn-1-specific diacylglycerol lipase"
RHEA:30379	skos:prefLabel	"beta-chamigrene synthase"
RHEA:30379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-chamigrene synthase"
RHEA:30379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate
RHEA:57659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1b <=> CMP + ganglioside GT1balpha + H(+)
RHEA:70464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 => a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate
RHEA:50185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine
RHEA:31761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine
REACT:R-SSC-5678261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Sus scrofa)
RHEA:22644	skos:prefLabel	"protopine 6-monooxygenase"
RHEA:22644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protopine 6-monooxygenase"
RHEA:22644	skos:altLabel	"protopine 6-hydroxylase"
RHEA:22644	skos:altLabel	"CYP82N2"
RHEA:22644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + protopine + reduced [NADPH--hemoprotein reductase] = 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate
RHEA:17791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + H(+) + S-adenosyl-L-homocysteine => (S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine
GO:0033936	skos:prefLabel	"polymannuronate hydrolase"
GO:0033936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(mannuronide) mannuronohydrolase activity
GO:0033936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polymannuronate hydrolase activity
GO:0033936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polymannuronate hydrolase"
GO:0033936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polymannuronic acid polymerase activity
REACT:R-MMU-5634103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 dissociates from atRA:RAR:RXR (Mus musculus)
RHEA:33609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + AMP + diphosphate => (9Z)-octadecenoate + ATP + CoA
RHEA:70503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopentenyl diphosphate = H(+) + isopentenyl phosphate + phosphate
REACT:R-HSA-9022365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIA2 gene expression is inhibited by MECP2:SIN3A complex (Homo sapiens)
REACT:R-DME-549304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal clearance of organic cations (Drosophila melanogaster)
GO:0047713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol 2-dehydrogenase activity
RHEA:13694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)
RHEA:60681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic aldehyde + H2O + NADP(+) => (+)-artemisinate + 2 H(+) + NADPH
REACT:R-DRE-173754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Properdin stabilizes C3b:Bb bound to cell surfaces (Danio rerio)
RHEA:66827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate
REACT:R-CFA-873926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNGR (Canis familiaris)
RHEA:66099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine
RHEA:12669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase"
RHEA:12669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate
RHEA:12669	skos:prefLabel	"[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase"
REACT:R-XTR-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Xenopus tropicalis)
REACT:R-RNO-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Rattus norvegicus)
REACT:R-HSA-437936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y348-SYK phosphorylates VAV family (Homo sapiens)
REACT:R-DDI-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Dictyostelium discoideum)
REACT:R-BTA-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Bos taurus)
REACT:R-DDI-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Dictyostelium discoideum)
REACT:R-RNO-6799178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)
REACT:R-RNO-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Rattus norvegicus)
RHEA:43372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + dTDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)
REACT:R-SSC-174439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Sus scrofa)
REACT:R-HSA-9656215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
REACT:R-GGA-1247668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A binds O2, releasing H+ and CO2 (Gallus gallus)
RHEA:70732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) => 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)
REACT:R-SSC-77614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR1) (Sus scrofa)
REACT:R-DME-4093329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SDCBP (Drosophila melanogaster)
RHEA:64090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O => acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA
REACT:R-HSA-168857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of vRNP:M1:NEP complex to CRM1 export receptor (Homo sapiens)
RHEA:71968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) => (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)
RHEA:37653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-CFA-5676589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANKL,sRANKL trimer binds RANK (Canis familiaris)
GO:0016798	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycosylase
GO:0016798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on glycosyl bonds
GO:0016798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosidase activity
GO:0016798	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	N-glycosylase
REACT:R-HSA-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Homo sapiens)
RHEA:44952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H(+) + NADPH = NADP(+) + octanoyl-CoA
REACT:R-RNO-2168885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin binds Hemoglobin (Rattus norvegicus)
RHEA:53311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:26171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-fumarylpyruvate + H2O <=> fumarate + H(+) + pyruvate
GO:0051003	skos:prefLabel	"Forming coordination complexes"
GO:0051003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming coordination complexes"
GO:0051003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase activity, forming nitrogen-metal bonds, forming coordination complexes
REACT:R-DDI-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Dictyostelium discoideum)
RHEA:63974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + pyriculol => A + dihydropyriculol
REACT:R-MMU-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Mus musculus)
REACT:R-DDI-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Dictyostelium discoideum)
REACT:R-SSC-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)
GO:0009676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity sulphate:hydrogen symporter activity
GO:0009676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low-affinity sulfate:proton symporter activity
GO:0009676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity sulfate:proton symporter activity
GO:0009676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low affinity sulfate:hydrogen symporter activity
GO:1990955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-rich single-stranded DNA binding
GO:0034893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-nitrodimethylamine hydroxylase activity
RHEA:21890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,15Z)-12-oxophytodienoate + H(+) + NADPH => (1S,2S)-OPC-8 + NADP(+)
RHEA:26395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => all-trans-zeaxanthin + 2 O2
REACT:R-BTA-9012349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)
RHEA:70159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate(in) + H(+)(in) = folate(out) + H(+)(out)
REACT:R-CEL-193143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)
RHEA:72885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AMP + 2 diphosphate + H(+) + polyporic acid => 2 3-phenylpyruvate + 2 ATP
RHEA:29485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-beta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-DME-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Drosophila melanogaster)
RHEA:56862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP] => a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate
REACT:R-SPO-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)
REACT:R-CEL-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Caenorhabditis elegans)
REACT:R-DDI-165195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP loading by Rheb (Dictyostelium discoideum)
REACT:R-MTU-936703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite is reduced to sulfide (Mycobacterium tuberculosis)
REACT:R-GGA-4641253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 ubiquitinates FZD to promote its downregulation (Gallus gallus)
REACT:R-MMU-9701000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1:BARD1 heterodimer autoubiquitinates (Mus musculus)
RHEA:46931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol
RHEA:54422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+) => 3',3'-c-di-AMP + H2O
REACT:R-BTA-5684273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
RHEA:55052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pentanoyl-CoA = CoA + H(+) + pentanoate
RHEA:20402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-lactam + H2O => a substituted beta-amino acid
RHEA:61408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-erythrulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine
RHEA:13632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5R)-carveol + NADP(+) <=> (R)-carvone + H(+) + NADPH
GO:0050480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity
GO:0050480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazolone-5-propionate hydrolase activity
GO:0050480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imidazolone propionic acid hydrolase activity
GO:0050480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazolonepropionase activity
GO:0050480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4(5)-imidazolone-5(4)-propionic acid hydrolase activity
REACT:R-RNO-5654714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
RHEA:32673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate => ATP + UDP-N-acetyl-alpha-D-glucosamine
GO:0047618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylagmatine amidohydrolase activity
GO:0047618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylagmatine amidase activity
GO:0047618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylagmatine deacylase activity
GO:0047618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoylagmatine amidohydrolase activity
RHEA:48737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Gallus gallus)
REACT:R-DRE-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)
REACT:R-HSA-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Homo sapiens)
REACT:R-CFA-5656105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Canis familiaris)
RHEA:13980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine <=> NH4(+) + pyruvate
RHEA:49385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-1655842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P hydrolyzes SREBP1A,1C,2 (Danio rerio)
REACT:R-DRE-2025890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds NFATC1,2,3 (Danio rerio)
REACT:R-RNO-391936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP1 receptor can bind PGE2 (Rattus norvegicus)
REACT:R-DDI-9020256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Dictyostelium discoideum)
REACT:R-BTA-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Bos taurus)
REACT:R-BTA-2028692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK4 (p-MST1) by caspase 3 (Bos taurus)
REACT:R-HSA-1482892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Homo sapiens)
REACT:R-MMU-5665989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIAPH1 binds RHOA:GTP (Mus musculus)
RHEA:40607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycerol + H2O = glycerol + H(+) + tetradecanoate
RHEA:58119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:29039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-aspartate(out) = ADP + H(+) + L-aspartate(in) + phosphate
REACT:R-CFA-74707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IRS to insulin receptor (Canis familiaris)
REACT:R-DME-209296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription (Drosophila melanogaster)
REACT:R-BTA-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Bos taurus)
REACT:R-XTR-9021306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds and inactivates C1r, C1s (Xenopus tropicalis)
REACT:R-HSA-70667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1PYR-5COOH spontaneously hydrolyses to L-GluSS (Homo sapiens)
RHEA:15823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + CO2 + hydrogen cyanide => 2 A + glycine
RHEA:64700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH
REACT:R-MMU-9709109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer binds DHFR inhibitors (Mus musculus)
REACT:R-DRE-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Danio rerio)
REACT:R-MMU-2681681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind fibronectin matrix (Mus musculus)
RHEA:69566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O => 12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine
REACT:R-RNO-5684887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of CHEK1 at resected DNA DSBs (Rattus norvegicus)
RHEA:71942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + 3 Na(+)(out) <=> 2-oxoglutarate(in) + 3 Na(+)(in)
RHEA:39271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z)-tetracosenoyl-CoA = (2E,15Z)-tetracosadienoyl-CoA + H2O
RHEA:71569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(L-seryl)-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + L-serine
REACT:R-RNO-8848005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 promotes PTK6 autophosphorylation (Rattus norvegicus)
REACT:R-SPO-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Schizosaccharomyces pombe)
RHEA:49552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate
RHEA:46140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-428231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Caenorhabditis elegans)
REACT:R-CFA-6807027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)
REACT:R-CFA-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Canis familiaris)
REACT:R-SSC-451757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of nephrin and KIRREL2, KIRREL3 (Sus scrofa)
REACT:R-HSA-9698677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCMV UL36 binds MLKL (Homo sapiens)
RHEA:36905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine
RHEA:39693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + NADP(+) => (2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH
RHEA:71782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate(out) + H(+)(out) <=> 4-methyl-2-oxopentanoate(in) + H(+)(in)
RHEA:30834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose
REACT:R-BTA-9689680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNG inhibitors (Bos taurus)
RHEA:69701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O
RHEA:31531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginine + O2 = CO2 + N(omega)-hydroxy-L-arginine + succinate
REACT:R-BTA-3296326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR1 binds LACT (Bos taurus)
RHEA:40693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol
REACT:R-MMU-9026894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PCLG1 dissociates from NTRK2 (Mus musculus)
REACT:R-XTR-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Xenopus tropicalis)
REACT:R-SCE-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Saccharomyces cerevisiae)
REACT:R-BTA-6810233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)
RHEA:21470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-beta-D-mycaminosyltylactone + dTDP + H(+) => dTDP-alpha-D-mycaminose + tylactone
REACT:R-BTA-8853444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PHLDA1 (Bos taurus)
REACT:R-HSA-1168768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds STAT1/3 (Homo sapiens)
REACT:R-BTA-5649701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Bos taurus)
GO:0001091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II general transcription initiation factor binding
GO:0001091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II basal transcription factor binding
REACT:R-RNO-5607756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomer autoubiquitinates (Rattus norvegicus)
REACT:R-XTR-416530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1:FFAR1 ligands activates Gq (Xenopus tropicalis)
REACT:R-HSA-4088307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXM1 binds CCNB1 promoter (Homo sapiens)
REACT:R-XTR-1247668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A binds O2, releasing H+ and CO2 (Xenopus tropicalis)
RHEA:17772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:31582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate
REACT:R-BTA-5212679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3A binds Me2sR4-HIST1H4 (Bos taurus)
REACT:R-HSA-870538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Homo sapiens)
RHEA:30007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) + phosphate
RHEA:17700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridine + thiamine <=> 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine
RHEA:14769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-nicotine + A + H2O = (R)-6-hydroxynicotine + AH2
RHEA:14769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotine dehydrogenase"
RHEA:14769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2
RHEA:14769	skos:prefLabel	"nicotine dehydrogenase"
RHEA:14769	skos:altLabel	"L-nicotine oxidase"
GO:0019828	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aspartic protease inhibitor activity
GO:0019828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartic-type endopeptidase inhibitor activity
GO:0030797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	24-methylenelophenol C-24(1)-methyltransferase activity
GO:0030797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SMT2
GO:0030797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	24-methylenelophenol C-241-methyltransferase activity
GO:0030797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenesterol C-methyltransferase activity
GO:0030797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity
GO:0030797	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SMT(2) activity
REACT:R-HSA-2454118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cRAL binds to opsin to form 11c-retinyl:RHO (Homo sapiens)
REACT:R-RNO-9026405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Rattus norvegicus)
RHEA:63700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolate + UDP-alpha-D-glucuronate = mycophenolic acid O-acyl-beta-D-glucuronide + UDP
REACT:R-RNO-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Rattus norvegicus)
REACT:R-DRE-8987220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Danio rerio)
REACT:R-DDI-162830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)
EC:3.6.1.5	skos:altLabel	"ADPase"
EC:3.6.1.5	skos:altLabel	"ATP-diphosphatase"
EC:3.6.1.5	skos:prefLabel	"apyrase"
EC:3.6.1.5	skos:altLabel	"ATP-diphosphohydrolase"
EC:3.6.1.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"apyrase"
EC:3.6.1.5	skos:altLabel	"adenosine diphosphatase"
REACT:R-HSA-202459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Bcl10 (Homo sapiens)
REACT:R-CFA-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
REACT:R-RNO-9020256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Rattus norvegicus)
RHEA:52717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)
REACT:R-SSC-2569057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP3 binds TRIF to mediate necroptosis (Sus scrofa)
REACT:R-CFA-163090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation Of The Telomeric Chromosome End (Canis familiaris)
REACT:R-DME-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)
RHEA:14999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxylimononate D-ring-lactone + H(+) => deoxylimonoate + H2O
REACT:R-CFA-186778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 binds to the active receptor (Canis familiaris)
REACT:R-SCE-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Saccharomyces cerevisiae)
GO:0016759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellulose synthetase activity
GO:0016759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellulose synthase activity
REACT:R-BTA-6786012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Bos taurus)
REACT:R-GGA-5218640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates p-Y397-PTK2 (Gallus gallus)
REACT:R-SPO-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Schizosaccharomyces pombe)
REACT:R-BTA-389348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by pVav1 (Bos taurus)
REACT:R-RNO-8850797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK13 (Rattus norvegicus)
GO:0000166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide binding
RHEA:38844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine
RHEA:34292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP
RHEA:39477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA
RHEA:38968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine(in) + ATP + H2O => ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate
RHEA:68787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> diphosphate + gamma-curcumene
RHEA:10064	skos:prefLabel	"D-alanine 2-hydroxymethyltransferase"
RHEA:10064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine
RHEA:10064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-alanine 2-hydroxymethyltransferase"
RHEA:10064	skos:altLabel	"2-methylserine hydroxymethyltransferase"
RHEA:10064	skos:altLabel	"D-alanine hydroxymethyltransferase"
REACT:R-GGA-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Gallus gallus)
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside 5'-diphosphate kinase activity
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside diphosphate (UDP) kinase activity
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleotide phosphate kinase activity
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside 5'-diphosphate phosphotransferase activity
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-diphosphate kinase activity
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside diphosphate kinase activity
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP kinase activity
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:nucleoside-diphosphate phosphotransferase activity
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate kinase activity
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDK activity
GO:0004550	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside diphosphokinase activity
RHEA:69676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eriodictyol-7-O-beta-D-glucoside + H2O => (S)-eriodictyol + beta-D-glucose
RHEA:59526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein] => 9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein]
RHEA:58133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine
REACT:R-HSA-9008480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates RUNX2 (Homo sapiens)
GO:0018769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity
REACT:R-HSA-9010231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO1 binds FLRT3 (Homo sapiens)
REACT:R-SSC-379387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DA to form 3MT (Sus scrofa)
RHEA:16883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate
RHEA:11319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic aldoxime <=> a nitrile + H2O
GO:0015498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pantothenate:sodium symporter activity
REACT:R-XTR-8944230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Xenopus tropicalis)
REACT:R-CEL-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Caenorhabditis elegans)
REACT:R-HSA-426489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC binds inexactly matching target RNAs (Homo sapiens)
REACT:R-CFA-74736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)
RHEA:51725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-tetraphosphate + ADP + 2 H(+)
REACT:R-HSA-377644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of CSK from SRC (Homo sapiens)
REACT:R-DRE-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Danio rerio)
RHEA:11676	skos:prefLabel	"ribose 1-dehydrogenase (NADP(+))"
RHEA:11676	skos:altLabel	"NADP-pentose-dehydrogenase"
RHEA:11676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribose 1-dehydrogenase (NADP(+))"
RHEA:11676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose + H2O + NADP(+) = D-ribonate + 2 H(+) + NADPH
REACT:R-RNO-2022052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Rattus norvegicus)
REACT:R-RNO-4420153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)
REACT:R-MMU-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Mus musculus)
REACT:R-HSA-175983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfer CH3 from AdoMet to 3,4DHBNZ (Homo sapiens)
REACT:R-MMU-6805470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates TP53 (Mus musculus)
REACT:R-HSA-5652099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)
GO:0008233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase, acting on peptide bonds
GO:0008233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidase activity
GO:0008233	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peptidase activity, acting on L-amino acid peptides
GO:0008233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protease activity
GO:0008233	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proteinase activity
GO:0008233	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peptidase activity, acting on D-amino acid peptides
GO:0008233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide hydrolase activity
RHEA:43062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate
REACT:R-SSC-203613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylation of eNOS (Sus scrofa)
REACT:R-PFA-352029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Plasmodium falciparum)
RHEA:60482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-di-UMP + 2 diphosphate => 2 UTP
REACT:R-DME-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Drosophila melanogaster)
REACT:R-HSA-5654607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PPTN11 (Homo sapiens)
RHEA:53026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+) => a plastoquinone + H2O + L-arginine
RHEA:31970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:29075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(out) + 2 H(+)(in) + ubiquinone-8 = CO2(out) + H(+)(out) + ubiquinol-8
RHEA:18629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(+) kinase"
RHEA:18629	skos:altLabel	"DPN kinase"
RHEA:18629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NAD(+) = ADP + H(+) + NADP(+)
RHEA:18629	skos:prefLabel	"NAD(+) kinase"
REACT:R-SPO-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)
RHEA:23006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine
GO:0052677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ARD1p
GO:0052677	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-arabinitol:NADP+ dehydrogenase activity
GO:0052677	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP+-dependent D-arabinitol dehydrogenase activity
GO:0052677	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-arabinitol dehydrogenase 1 activity
GO:0052677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
REACT:R-SSC-2468287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)
REACT:R-RNO-5668545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK autophosphorylates on T559 (Rattus norvegicus)
RHEA:56191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
RHEA:38434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)
REACT:R-RNO-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Rattus norvegicus)
REACT:R-GGA-4085296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NCOA1 with SUMO1 (Gallus gallus)
REACT:R-XTR-8848247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD4,5 bind MCFA-CoA and LCFA-CoA (Xenopus tropicalis)
RHEA:59905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + octanal => 2 H(+) + NADPH + octanoate
REACT:R-HSA-209765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)
REACT:R-DRE-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Danio rerio)
RHEA:32377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxylimonen-2-one + H(+) + NADH => limonene-1,2-diol + NAD(+)
RHEA:35931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP
REACT:R-HSA-202437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 (Homo sapiens)
RHEA:63903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O
GO:0047918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity
GO:0047918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-D-mannose:GDP-L-galactose epimerase activity
GO:0047918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-mannose 3,5-epimerase activity
GO:0047918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPmannose 3,5-epimerase activity
REACT:R-CEL-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Caenorhabditis elegans)
RHEA:62538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrodigoxigenin + 2 Fe(III)-[cytochrome c] => digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+)
REACT:R-CEL-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Caenorhabditis elegans)
REACT:R-GGA-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Gallus gallus)
REACT:R-CEL-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)
REACT:R-RNO-5653974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator binds Rag dimers (Rattus norvegicus)
RHEA:42395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + NAD(+) <=> D-galactono-1,5-lactone + H(+) + NADH
RHEA:69497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decan-1-ol + O2 => decanal + H2O2
RHEA:46912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juvenile hormone III = H(+) + juvenile hormone III carboxylate + methanol
REACT:R-HSA-8982617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB:O2 dissociates (Homo sapiens)
RHEA:67899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end uridylyl-adenosine-RNA <=> a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine
RHEA:60796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 = 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate
RHEA:40237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M-coenzyme B heterodisulfide + succinate => coenzyme B + coenzyme M + fumarate
GO:0046811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone deacetylase inhibitor activity
RHEA:36805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein + H(+) + H2O => 2-hydroxy-2,3-dihydrogenistein
REACT:R-XTR-1675773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)
REACT:R-DRE-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Danio rerio)
GO:0051864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-lysine (H3-K36) demethylase activity
GO:0051864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-lysine(H3-K36) demethylase activity
GO:0051864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[histone-H3]-lysine-36 demethylase activity
GO:0051864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-lysine-36 demethylase activity
GO:0051864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone demethylase activity (H3-K36 specific)
GO:0051864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K36 demethylase activity
GO:0051864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36 demethylase activity
GO:0051864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-methyl-lysine-36 demethylase activity
GO:0051864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-lysine demethylase activity (H3-K36 specific)
RHEA:53811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-417843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y13 binds ADP (Sus scrofa)
RHEA:10524	skos:prefLabel	"2-oxoglutarate decarboxylase"
RHEA:10524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoglutarate decarboxylase"
RHEA:10524	skos:altLabel	"2-oxoglutarate carboxy-lyase"
RHEA:10524	skos:altLabel	"alpha-ketoglutarate decarboxylase"
RHEA:10524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) = CO2 + succinate semialdehyde
GO:0046526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose reductase activity
GO:0046526	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylitol dehydrogenase activity
RHEA:37490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:62735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide D + FADH2
REACT:R-GGA-421493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA + glycine => delta-aminolevulinate + CoA SH + CO2 (Gallus gallus)
RHEA:67823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:33155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-lysophosphatidate phosphatase"
RHEA:33155	skos:altLabel	"1-acyl-sn-glycerol 3-phosphatase"
RHEA:33155	skos:prefLabel	"2-lysophosphatidate phosphatase"
RHEA:33155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate
RHEA:65630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine => sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA
GO:0015240	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amiloride transporter activity
GO:0015240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amiloride transmembrane transporter activity
RHEA:64876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP = H(+) + phosphate + UMP
REACT:R-DME-8964274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12) binds BTK (Drosophila melanogaster)
RHEA:65239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol + acetyl-CoA <=> 3-methylbutyl acetate + CoA
RHEA:21930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxo-L-gulonate + H(+) + NADPH => 3-dehydro-L-gulonate + NADP(+)
RHEA:17462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate
REACT:R-DRE-6791219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Danio rerio)
RHEA:67336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 3-O-beta-D-glucoside + malonyl-CoA = CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)
RHEA:55418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biochanin A 7-O-beta-D-glucoside + H(+) + UDP => biochanin A + UDP-alpha-D-glucose
REACT:R-HSA-3791349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease) (Homo sapiens)
GO:0047692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP deaminase activity
GO:0047692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine triphosphate deaminase activity
GO:0047692	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP aminohydrolase activity
RHEA:46523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-SSC-420123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like receptor 2 binds GLP2 (Sus scrofa)
GO:0017020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin phosphatase regulator activity
GO:0017020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myosin phosphatase, intrinsic regulator activity
REACT:R-BTA-77271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Bos taurus)
RHEA:48465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1b + H2O => ganglioside GA1 + N-acetylneuraminate
REACT:R-BTA-6805035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds STK11 and NUAK1 (Bos taurus)
RHEA:69386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] => (R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)
REACT:R-HSA-6782388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA) (Homo sapiens)
REACT:R-DRE-9605700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Danio rerio)
REACT:R-BTA-9756156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes ATV to ATVL (Bos taurus)
RHEA:13508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + O2 <=> betaine aldehyde + H2O2
REACT:R-RNO-174255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation multiubiquitinated Cyclin A (Rattus norvegicus)
REACT:R-DRE-389756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT interacts and phosphorylates Cot (Danio rerio)
GO:0042959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkanesulfonate transmembrane transporter activity
GO:0042959	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkanesulfonate transporter activity
GO:0042959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkanesulphonate transporter activity
RHEA:50861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + AH2 + O2 => 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
RHEA:59317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose + O2 => D-cellobiono-1,5-lactone + H2O2
REACT:R-RNO-74220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Rattus norvegicus)
REACT:R-SSC-6799097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates ZNF420 (Sus scrofa)
GO:0018550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrachloro-p-hydroquinone reductive dehalogenase activity
GO:0018550	skos:prefLabel	"With other acceptors"
GO:0018550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
GO:0018550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrachlorohydroquinone reductive dehalogenase activity
REACT:R-DDI-76475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Dictyostelium discoideum)
REACT:R-GGA-191636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cx43 by c-src (Gallus gallus)
REACT:R-CFA-8939801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades PolyUb-RUNX2 (Canis familiaris)
REACT:R-DME-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Drosophila melanogaster)
REACT:R-DDI-9014074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin4 (Dictyostelium discoideum)
REACT:R-DRE-9725855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds NR3C2 antagonists (Danio rerio)
RHEA:62355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide D
REACT:R-SSC-9008271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Sus scrofa)
RHEA:48606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein]
REACT:R-CFA-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Canis familiaris)
REACT:R-CFA-8987063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Canis familiaris)
RHEA:21471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-mycaminose + tylactone <=> 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)
REACT:R-XTR-4332236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL neddylates TGFBR2 (Xenopus tropicalis)
RHEA:39594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA <=> (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O
RHEA:60716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemal + H2O + NADP(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADPH
REACT:R-SSC-3159253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAB adenosylates cob(I)alamin (Sus scrofa)
REACT:R-MMU-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Mus musculus)
REACT:R-CFA-2574845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA binds centrosome-associated AURKA (Canis familiaris)
RHEA:67498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end CoA-ribonucleoside in mRNA + H2O
EC:1.17.9.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a copper protein as acceptor"
EC:1.17.9.-	skos:prefLabel	"With a copper protein as acceptor"
REACT:R-DRE-1307955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds HS:KLB:FGF19 (Danio rerio)
RHEA:25711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5690669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds itself to form homo-oligomers (Bos taurus)
REACT:R-CEL-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-DRE-4420117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR2 autophosphorylates (Danio rerio)
GO:0106329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)
GO:0106329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalaine oxidase activity
REACT:R-BTA-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Bos taurus)
REACT:R-CFA-8851919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 and GRB2 (Canis familiaris)
REACT:R-SSC-389652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Sus scrofa)
RHEA:68159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + L-glutamate <=> diphosphate + N-geranyl-L-glutamate
REACT:R-XTR-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Xenopus tropicalis)
RHEA:64432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-prolylglycine(out) = H(+)(in) + L-alanyl-L-prolylglycine(in)
REACT:R-HSA-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)
REACT:R-BTA-211966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2D6 4-hydroxylates debrisoquine (Bos taurus)
GO:0102594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity
RHEA:13497	skos:prefLabel	"5-dehydro-2-deoxygluconokinase"
RHEA:13497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-dehydro-2-deoxygluconokinase"
RHEA:13497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-2-deoxy-D-gluconate + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)
RHEA:13497	skos:altLabel	"5-keto-2-deoxygluconokinase"
RHEA:70634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-BTA-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Bos taurus)
REACT:R-SSC-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Sus scrofa)
RHEA:32188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-5-en-3-one => cholest-4-en-3-one
REACT:R-RNO-110356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MPG glycosylase by APEX1 at the AP site (Rattus norvegicus)
REACT:R-RNO-174105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated cell cycle proteins (Rattus norvegicus)
RHEA:71813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(in) => 3,3',5-triiodo-L-thyronine(out)
REACT:R-BTA-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Bos taurus)
REACT:R-XTR-9629195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Xenopus tropicalis)
GO:0043250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-dependent organic anion transmembrane transporter activity
RHEA:51917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-butenoate + H2O => 2-oxobutanoate + NH4(+)
REACT:R-CEL-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Caenorhabditis elegans)
RHEA:15498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate => 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine
REACT:R-SPO-1236970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasomal clevage of exogenous antigen (Schizosaccharomyces pombe)
RHEA:27392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> pyruvate + salicylaldehyde
RHEA:15669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)
REACT:R-MMU-162836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Mus musculus)
REACT:R-DDI-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Dictyostelium discoideum)
GO:0016412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine O-acyltransferase activity
GO:0016412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine O-acetyltransferase"
GO:0016412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
GO:0016412	skos:prefLabel	"serine O-acetyltransferase"
GO:0004482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	messenger RNA guanine 7-methyltransferase activity
GO:0004482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanine-7-methyltransferase activity
GO:0004482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity
GO:0004482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	messenger ribonucleate guanine 7-methyltransferase activity
GO:0004482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity
GO:0004482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA (guanine-N7-)-methyltransferase activity
RHEA:38237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + octadecan-1-ol
RHEA:54634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytetradecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + tetradecanoyl-CoA
REACT:R-MMU-194642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Mus musculus)
REACT:R-RNO-5333671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCAs self cleave (Rattus norvegicus)
RHEA:48507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-D-manno-heptose 1-phosphate + phosphate
RHEA:55436	skos:prefLabel	"salviol synthase"
RHEA:55436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salviol synthase"
RHEA:55436	skos:altLabel	"CYP71BE52"
RHEA:55436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol
RHEA:32305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-homoisocitrate => (2R)-homocitrate
REACT:R-CFA-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Canis familiaris)
RHEA:55163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:52967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyodeoxycholate + UDP-alpha-D-glucuronate <=> H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP
REACT:R-SSC-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Sus scrofa)
REACT:R-MMU-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Mus musculus)
RHEA:29386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + H2O <=> 2'-deoxyinosine + phosphate
RHEA:15205	skos:prefLabel	"oligosaccharide-diphosphodolichol diphosphatase"
RHEA:15205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligosaccharide-diphosphodolichol diphosphatase"
RHEA:15205	skos:altLabel	"oligosaccharide-diphosphodolichol pyrophosphatase"
RHEA:15205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphooligosaccharide + H2O = a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)
RHEA:36819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA
RHEA:54737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine
RHEA:58917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene => (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:54863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranial + H(+) + NADPH + O2 <=> (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)
REACT:R-RNO-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Rattus norvegicus)
REACT:R-BTA-1307955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds HS:KLB:FGF19 (Bos taurus)
RHEA:47576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = CMP + ganglioside GD1c (d18:1(4E)) + H(+)
REACT:R-DDI-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)
REACT:R-HSA-9707856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGRMC2:Hemes dissociates (Homo sapiens)
EC:1.14.14.139	skos:prefLabel	"5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase"
EC:1.14.14.139	skos:altLabel	"5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase"
EC:1.14.14.139	skos:altLabel	"sterol 12alpha-hydroxylase"
EC:1.14.14.139	skos:altLabel	"chenodeoxycholate 12alpha monooxygenase"
EC:1.14.14.139	skos:altLabel	"CYP8B1"
EC:1.14.14.139	skos:altLabel	"7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase"
EC:1.14.14.139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase"
EC:1.14.14.139	skos:altLabel	"7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase"
REACT:R-DME-209973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is diiodinated (Drosophila melanogaster)
REACT:R-XTR-352232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-SSC-2161795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Sus scrofa)
REACT:R-SSC-6807875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Sus scrofa)
REACT:R-HSA-5654159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds PLCG1 (Homo sapiens)
REACT:R-GGA-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Gallus gallus)
RHEA:34673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine
GO:0001094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIID-class transcription factor complex binding
GO:0001094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIID-class transcription factor binding
RHEA:49088	skos:prefLabel	"hydroxysqualene dehydroxylase"
RHEA:49088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + H2O + squalene = FADH2 + hydroxysqualene
RHEA:49088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxysqualene dehydroxylase"
RHEA:10511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate
RHEA:54927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]
RHEA:11932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanenitrile = acetone + hydrogen cyanide
REACT:R-RNO-140359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS1 (Rattus norvegicus)
RHEA:63990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-thiocytidine 5'-phosphate + ADP + H(+) => 2-thiocytidine + ATP
RHEA:21213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate
RHEA:52718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH
REACT:R-DRE-9705794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 binds SRD5A2 inhibitors (Danio rerio)
RHEA:17134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[tyrosine-3-monooxygenase] => ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]
RHEA:45796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH
REACT:R-SPO-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Schizosaccharomyces pombe)
REACT:R-SSC-8938773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A polyubiquitinates PRKDC (Sus scrofa)
REACT:R-DME-9009526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Drosophila melanogaster)
REACT:R-SSC-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Sus scrofa)
GO:0080132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Homo sapiens)
GO:0080132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid 2-hydroxylase
GO:0080132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid alpha-hydroxylase activity
RHEA:37598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-XTR-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Xenopus tropicalis)
REACT:R-MMU-191654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-src associates with Cx43 in gap junctions (Mus musculus)
REACT:R-CFA-9023633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)
RHEA:43313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(hexanoyl)sphing-4-enine => ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate
REACT:R-DME-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)
RHEA:42534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(55) in tRNA => uridine(55) in tRNA
GO:0004982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formyl peptide receptor activity
GO:0004982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fmet-leu-phe receptor
REACT:R-RNO-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Rattus norvegicus)
REACT:R-DME-390674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB1 bind ADR,NAd (Drosophila melanogaster)
REACT:R-BTA-936897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
RHEA:63456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + CTP = (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)
RHEA:11928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylamine + NH4(+) = H(+) + H2O + hydrazine
RHEA:42597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2
EC:3.4.23.1	skos:prefLabel	"pepsin A"
EC:3.4.23.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pepsin A"
EC:3.4.23.1	skos:altLabel	"pepsin"
GO:0097003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKH receptor activity
GO:0097003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adipokinetic hormone receptor activity
RHEA:54470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate => 1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:68644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = alpha-thujene + diphosphate
RHEA:26328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine
RHEA:12192	skos:prefLabel	"(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase"
RHEA:12192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase"
RHEA:12192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate
REACT:R-DDI-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Dictyostelium discoideum)
REACT:R-BTA-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
RHEA:68203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoylglycerol + hexadecanoyl-CoA <=> 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA
REACT:R-HSA-981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I inactivates C4BP-bound C4b (Homo sapiens)
RHEA:27350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate + mycothiol => arseno-mycothiol + H2O
GO:0008912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + H(+) + NADH
GO:0008912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity
GO:0008912	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	propanediol oxidoreductase activity
GO:0008912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactaldehyde reductase activity
GO:0008912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + H(+) + NADH
GO:0008912	skos:altLabel	"propanediol oxidoreductase"
GO:0008912	skos:prefLabel	"lactaldehyde reductase"
GO:0008912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactaldehyde:propanediol oxidoreductase activity
GO:0008912	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity
GO:0008912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactaldehyde reductase"
RHEA:67248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH
REACT:R-HSA-9667456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B bind desmopressin (Homo sapiens)
RHEA:18925	skos:prefLabel	"glucuronolactone reductase"
RHEA:18925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronolactone reductase"
RHEA:18925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH
REACT:R-SSC-9652580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Sus scrofa)
REACT:R-CFA-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Canis familiaris)
REACT:R-CFA-6803875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds CDK1 and CCNB1 (Canis familiaris)
REACT:R-CFA-5607725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
REACT:R-HSA-1852623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of NICD1 by FBWX7 (Homo sapiens)
REACT:R-DRE-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Danio rerio)
RHEA:42421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysine + O2 => (4R)-4-hydroxy-L-lysine + CO2 + succinate
REACT:R-RNO-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Rattus norvegicus)
RHEA:30698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal + H2O + NAD(+) <=> beta-alanine + 2 H(+) + NADH
RHEA:29053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + menaquinol-8 => 2 H(+)(in) + H2 + menaquinone-8
REACT:R-SSC-390909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds hist (Sus scrofa)
REACT:R-DME-5654625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds SHC1 (Drosophila melanogaster)
REACT:R-HSA-6800798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome binds CASP2 (Homo sapiens)
REACT:R-SPO-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Schizosaccharomyces pombe)
RHEA:44608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
RHEA:57735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-7,8-dihydroretinol <=> AH2 + all-trans-retinol
REACT:R-RNO-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Rattus norvegicus)
RHEA:40201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:59709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotriono-1,5-lactone + H2O => D-maltotrionate + H(+)
RHEA:24445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]
REACT:R-MMU-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)
REACT:R-SSC-2730842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K associates with phosphorylated GAB2 (Sus scrofa)
RHEA:49719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 <=> 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)
REACT:R-MMU-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
REACT:R-BTA-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Bos taurus)
GO:0047392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-sialic acid hydrolase activity
GO:0047392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphosialate hydrolase activity
GO:0047392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphate-N-acetylneuraminic acid hydrolase activity
GO:0047392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate hydrolase activity
GO:0047392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acylneuraminate N-acylneuraminohydrolase activity
GO:0047392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphosialic hydrolase activity
GO:0047392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acylneuraminate phosphodiesterase activity
GO:0047392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-sialate hydrolase activity
GO:0047392	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acylneuraminic acid hydrolase activity
RHEA:67018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]
REACT:R-CEL-8849055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARHGAP35 (Caenorhabditis elegans)
RHEA:61648	skos:prefLabel	"salicylate--[aryl-carrier protein] ligase"
RHEA:61648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[non-ribosomal peptide synthase] + salicylate = AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]
RHEA:61648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salicylate--[aryl-carrier protein] ligase"
RHEA:30895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + propane-1,3-diamine = 3-aminopropanal + H2O2 + NH4(+)
RHEA:71272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + thiamine(out) => H(+)(out) + thiamine(in)
RHEA:40341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP
RHEA:49716	skos:prefLabel	"3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase"
RHEA:49716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase"
RHEA:49716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)
REACT:R-SSC-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Sus scrofa)
RHEA:38718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + choline(out) + H2O <=> ADP + choline(in) + H(+) + phosphate
RHEA:28557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose 6-phosphate + H2O <=> D-mannose + phosphate
REACT:R-HSA-2201322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIRAP is phosphorylated by BTK (Homo sapiens)
RHEA:27570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glycero-alpha-D-manno-heptose-7-phosphate kinase"
RHEA:27570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glycero-alpha-D-manno-heptose 7-phosphate = ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)
RHEA:27570	skos:altLabel	"D-alpha-D-heptose-7-phosphate kinase"
RHEA:27570	skos:prefLabel	"D-glycero-alpha-D-manno-heptose-7-phosphate kinase"
REACT:R-XTR-9036307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPER:Heterotrimeric G-protein Gs binds ESTG (Xenopus tropicalis)
REACT:R-CEL-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Caenorhabditis elegans)
RHEA:37933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
RHEA:19800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + H2O <=> 1D-myo-inositol 1,4-bisphosphate + phosphate
REACT:R-SSC-1433395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of sSCF (Sus scrofa)
REACT:R-SSC-5607720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p100:RELB binds active NIK:p-IKKA dimer (Sus scrofa)
EC:2.7.8.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phospho-N-acetylmuramoyl-pentapeptide-transferase"
EC:2.7.8.13	skos:altLabel	"phospho-NAc-muramoyl-pentapeptide translocase (UMP)"
EC:2.7.8.13	skos:altLabel	"phosphoacetylmuramoylpentapeptide translocase"
EC:2.7.8.13	skos:altLabel	"UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase"
EC:2.7.8.13	skos:altLabel	"phospho-MurNAc-pentapeptide transferase"
EC:2.7.8.13	skos:altLabel	"phospho-N-acetylmuramoyl pentapeptide translocase"
EC:2.7.8.13	skos:altLabel	"phosphoacetylmuramoylpentapeptidetransferase"
EC:2.7.8.13	skos:altLabel	"UDP-MurNAc-pentapeptide phosphotransferase"
EC:2.7.8.13	skos:prefLabel	"phospho-N-acetylmuramoyl-pentapeptide-transferase"
EC:2.7.8.13	skos:altLabel	"MraY transferase"
EC:2.7.8.13	skos:altLabel	"UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase"
REACT:R-GGA-352893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose 6-phosphate <=> fructose 6-phosphate (Gallus gallus)
REACT:R-CEL-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Caenorhabditis elegans)
REACT:R-SSC-5607757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TRAF6 ubiquitinates TAK1 (Sus scrofa)
REACT:R-BTA-8851933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates GAB1 (Bos taurus)
REACT:R-CFA-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Canis familiaris)
RHEA:58628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV = FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal
REACT:R-MMU-1606583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Mus musculus)
RHEA:67055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + asnovolin J + O2 <=> A + asnovolin A + H2O
REACT:R-HSA-399936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of integrin activation by sequestering PIP5KIgamma (Homo sapiens)
REACT:R-CEL-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
RHEA:56676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroferuloyl-CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH
REACT:R-CFA-9627369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT4 binds XIAP (Canis familiaris)
GO:0071614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleic acid monooxygenase activity
GO:0071614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleic acid epoxygenase activity
REACT:R-RNO-8948800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNKS and TNKS2 PARylate PTEN (Rattus norvegicus)
REACT:R-GGA-163625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon binds to Glucagon receptor (Gallus gallus)
RHEA:44745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 malonyl-CoA => (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O
REACT:R-XTR-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)
RHEA:36797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate => a ribonucleoside 5'-triphosphate + 2 H2O
REACT:R-CEL-5252041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Caenorhabditis elegans)
REACT:R-RNO-5685156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2 (Rattus norvegicus)
REACT:R-HSA-2731075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds collagen types I, III, V (Homo sapiens)
REACT:R-MMU-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Mus musculus)
REACT:R-HSA-936564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 inhibits MAVS-DDX58 interaction. (Homo sapiens)
RHEA:62518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-MMU-8848215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Mus musculus)
RHEA:26534	skos:altLabel	"3-hydroxypropionate--CoA ligase"
RHEA:26534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxypropionyl-CoA synthase"
RHEA:26534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate
RHEA:26534	skos:prefLabel	"3-hydroxypropionyl-CoA synthase"
RHEA:26534	skos:altLabel	"3-hydroxypropionyl-CoA synthetase (AMP-forming)"
REACT:R-SSC-159795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Sus scrofa)
REACT:R-BTA-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Bos taurus)
REACT:R-HSA-9694732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3CLp cleaves pp1ab (Homo sapiens)
REACT:R-HSA-445091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Neurofascin (Homo sapiens)
REACT:R-BTA-111237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR1 homodimer (Bos taurus)
REACT:R-DME-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-SSC-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Sus scrofa)
RHEA:23081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnonate => 2-dehydro-3-deoxy-L-rhamnonate + H2O
RHEA:51612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + oxaloacetate = (R)-malate + 2-oxoglutarate
REACT:R-HSA-9618405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL4C mRNA is translated (Homo sapiens)
REACT:R-HSA-5620921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)
REACT:R-MMU-178208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF2 (Mus musculus)
RHEA:55751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Canis familiaris)
RHEA:49473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose => H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP
REACT:R-RNO-9691174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the ER membrane (Rattus norvegicus)
REACT:R-CFA-2130504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of lip22 to lip10 (Canis familiaris)
RHEA:20008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-glucuronoside + H2O <=> an alcohol + D-glucuronate
REACT:R-SSC-432946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB/Affixin interacts with alpha PIX (Sus scrofa)
REACT:R-XTR-8863718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGFG1 binds VAMP7 (Xenopus tropicalis)
RHEA:70655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + sarcosine(in) = H(+)(out) + sarcosine(out)
REACT:R-XTR-351894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of BAP31 (Xenopus tropicalis)
GO:0045031	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-activated adenosine receptor activity
GO:0045031	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP-activated nucleotide receptor activity
GO:0045031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled ATP receptor activity
REACT:R-CFA-71541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Canis familiaris)
REACT:R-GGA-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Gallus gallus)
REACT:R-SSC-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Sus scrofa)
RHEA:62803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 7-demethylsiderin + NADPH + O2 <=> 2 H2O + NADP(+) + orlandin
REACT:R-CFA-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Canis familiaris)
RHEA:13663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formyl-L-aspartate + NH4(+) => H2O + N-formimidoyl-L-aspartate
RHEA:72079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + selenate(out) = 3 Na(+)(in) + selenate(in)
RHEA:69735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylsuccinate + succinyl-CoA = 2-phenylsuccinyl-CoA + succinate
RHEA:26206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + H(+) + NADPH + O2 => 4-nitrocatechol + H2O + NADP(+)
RHEA:27306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-proline dehydrogenase"
RHEA:27306	skos:altLabel	"D-Pro DH"
RHEA:27306	skos:prefLabel	"D-proline dehydrogenase"
RHEA:27306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-proline = 1-pyrroline-2-carboxylate + AH2
RHEA:27306	skos:altLabel	"D-Pro dehydrogenase"
RHEA:17064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + phenol <=> catechol + H2O + NADP(+)
REACT:R-SSC-8952371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds RUNX3 (Sus scrofa)
RHEA:63857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecanoate => (2R)-2-hydroperoxytetradecanoate
RHEA:56293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:13124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + shikimate <=> 3-phosphoshikimate + ADP + H(+)
GO:0016301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphokinase activity
GO:0016301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinase activity
RHEA:21156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate + H2O = (R)-glycerate + phosphate
RHEA:21156	skos:prefLabel	"phosphoglycerate phosphatase"
RHEA:21156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglycerate phosphatase"
REACT:R-DDI-6787533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Dictyostelium discoideum)
REACT:R-HSA-5607750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Homo sapiens)
REACT:R-DRE-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)
GO:1903425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoride transmembrane transporter activity
REACT:R-BTA-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Bos taurus)
RHEA:72969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate(in) + 2 Na(+)(in) => 4-methyl-2-oxopentanoate(out) + 2 Na(+)(out)
REACT:R-BTA-178208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF2 (Bos taurus)
RHEA:62807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 7-demethylsiderin + NADPH + O2 <=> desertorin A + 2 H2O + NADP(+)
REACT:R-DME-165162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TSC2 by PKB (Drosophila melanogaster)
REACT:R-DRE-168933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of phosphorylated IRF3/IRF7 (Danio rerio)
REACT:R-MMU-192051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP7A1 7-hydroxylates CHOL (Mus musculus)
RHEA:33952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribostamycin + UDP-N-acetyl-alpha-D-glucosamine => 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP
RHEA:50212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate
REACT:R-GGA-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)
REACT:R-HSA-8964340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq-BTK complex dissociates to Active BTK and Gq (Homo sapiens)
RHEA:53327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin E2
REACT:R-SSC-4086132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin phosphoprotein binds integrin alphaVbeta1 (Sus scrofa)
RHEA:71856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurochenodeoxycholate(out) => taurochenodeoxycholate(in)
REACT:R-MMU-3134954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX9 binds DNA (Mus musculus)
REACT:R-XTR-1793182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Xenopus tropicalis)
GO:0034212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide N-acetyltransferase activity
GO:0034212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 acetylation at Lys80 (Homo sapiens)
REACT:R-RNO-5689861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of XPA and release of CAK  (Rattus norvegicus)
REACT:R-BTA-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)
RHEA:58190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroisopentenyldehydrorhodopin + diphosphate => all-trans-lycopene + dimethylallyl diphosphate + H2O
REACT:R-CFA-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Canis familiaris)
REACT:R-CFA-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Canis familiaris)
RHEA:20031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + vellosimine => 10-deoxysarpagine + NADP(+)
REACT:R-BTA-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Bos taurus)
REACT:R-RNO-2161899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Rattus norvegicus)
REACT:R-XTR-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Xenopus tropicalis)
REACT:R-BTA-158137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Bos taurus)
REACT:R-RNO-5676940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Rattus norvegicus)
RHEA:12142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+) => a 2'-deoxyribonucleoside + ATP
REACT:R-DRE-1482647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Danio rerio)
GO:0102876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	psoralen synthase activity
REACT:R-HSA-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)
RHEA:37558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-kanosamine 6-phosphate + H2O <=> kanosamine + phosphate
REACT:R-RNO-5694563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD10 hydrolyses MPAG (Rattus norvegicus)
REACT:R-CFA-3781024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Canis familiaris)
RHEA:30908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) => 2-methylbutanoyl-CoA + CO2 + NADH
RHEA:15957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O
RHEA:15957	skos:prefLabel	"altronate dehydratase"
RHEA:15957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"altronate dehydratase"
REACT:R-SCE-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Saccharomyces cerevisiae)
RHEA:12786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alditol + NAD(+) => an aldose + H(+) + NADH
RHEA:35010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fucose(in) <=> D-fucose(out)
RHEA:31116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin + H(+) => biotinyl-5'-AMP + diphosphate
REACT:R-DME-5654587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS phosphorylates PPTN11 (Drosophila melanogaster)
RHEA:15016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha(S)-strictosidine + H2O <=> secologanin + tryptamine
REACT:R-CEL-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Caenorhabditis elegans)
RHEA:53314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Drosophila melanogaster)
REACT:R-MMU-211910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Mus musculus)
REACT:R-HSA-9009536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX5 binds ESR1:estrogen:TFF1 gene promoter (Homo sapiens)
RHEA:69291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate <=> sulfate + sulforaphane
REACT:R-HSA-377640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of SRC (Homo sapiens)
EC:3.1.26.2	skos:prefLabel	"ribonuclease alpha"
EC:3.1.26.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease alpha"
REACT:R-XTR-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Xenopus tropicalis)
RHEA:46584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] = 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5623513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 stimulates GTPase activity of ARF4 (Gallus gallus)
RHEA:19368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribulose 5-phosphate <=> ADP + D-ribulose 1,5-bisphosphate + H(+)
RHEA:63474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + all-trans-hexaprenyl phosphate + H(+) => all-trans-hexaprenol + ATP
RHEA:62000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX
REACT:R-CFA-446648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Canis familiaris)
RHEA:50297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] => 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0002134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP binding
REACT:R-HSA-909719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)
RHEA:56534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate
REACT:R-PFA-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Plasmodium falciparum)
RHEA:39406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)
REACT:R-GGA-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)
REACT:R-MMU-2243926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of histidino-hydroxylysinonorleucine cross-links (Mus musculus)
REACT:R-RNO-9700120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTN and MDK bind to PTPRZ (Rattus norvegicus)
RHEA:59120	skos:prefLabel	"2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase"
RHEA:59120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2
RHEA:59120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase"
RHEA:29887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-lysine(out) = ADP + H(+) + L-lysine(in) + phosphate
REACT:R-BTA-2203479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2 (FEEL-2) binds ligands (Bos taurus)
RHEA:67630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate => ATP + dGMP + L-aspartate
REACT:R-HSA-2429643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
REACT:R-MMU-6806613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin tetramers bind to form unit length filaments (Mus musculus)
REACT:R-DME-190408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2b (Drosophila melanogaster)
REACT:R-XTR-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Xenopus tropicalis)
REACT:R-HSA-9614778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAG gene expression (Homo sapiens)
REACT:R-HSA-5696131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC1 deaminates Hist (Homo sapiens)
REACT:R-RNO-373750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:ErbB2 (Rattus norvegicus)
REACT:R-CEL-204364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO1 binds SLIT2 (Caenorhabditis elegans)
REACT:R-CFA-375384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bombesin-like receptors bind bombesin homologues (Canis familiaris)
REACT:R-MMU-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Mus musculus)
RHEA:33946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 L-arginine + 3 NADH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide
RHEA:24184	skos:altLabel	"4,5-dihydroxyphthalate carboxy-lyase"
RHEA:24184	skos:prefLabel	"4,5-dihydroxyphthalate decarboxylase"
RHEA:24184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4,5-dihydroxyphthalate decarboxylase"
RHEA:24184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2
RHEA:46886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
GO:0008849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterochelin esterase activity
GO:0008849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin esterase activity
RHEA:63005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienamide + H2O => (11Z,14Z)-eicosadienoate + NH4(+)
REACT:R-HSA-2470555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type X binds Integrin alpha2beta1 (Homo sapiens)
REACT:R-XTR-1980233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Xenopus tropicalis)
RHEA:43290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O
GO:0008796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(5'-nucleosyl)-tetraphosphatase activity
RHEA:70913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate
RHEA:14491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 2'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O
GO:0097160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polychlorinated biphenyl binding
GO:0097160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCB binding
GO:0097160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polychlorobiphenyl binding
RHEA:13565	skos:altLabel	"Tag polymerase"
RHEA:13565	skos:altLabel	"teichoic acid glycerol transferase"
RHEA:13565	skos:altLabel	"teichoic-acid synthase"
RHEA:13565	skos:prefLabel	"teichoic acid poly(glycerol phosphate) polymerase"
RHEA:13565	skos:altLabel	"poly(glycerol phosphate) polymerase"
RHEA:13565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"teichoic acid poly(glycerol phosphate) polymerase"
RHEA:13565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol = 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)
RHEA:57934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+)
RHEA:37392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
RHEA:66214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-omegaDeltaC5-CoA + H2O2 => asc-omegaC5-CoA + O2
GO:0018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity
REACT:R-GGA-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Gallus gallus)
RHEA:63890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine => hexadecanoyl-CoA + sphinga-4E,14Z-dienine
RHEA:58538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoylglycine => glycine + hexadecanoyl-CoA
REACT:R-CFA-5694126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)
REACT:R-CFA-1676185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Canis familiaris)
REACT:R-XTR-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Xenopus tropicalis)
RHEA:17856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-sorbose + O2 <=> 5-dehydro-D-fructose + H2O2
REACT:R-MMU-5205822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-18 (H3R17) of histone H3 (Mus musculus)
REACT:R-RNO-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Rattus norvegicus)
REACT:R-XTR-6785986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases unhook the interstrand crosslink (ICL) (Xenopus tropicalis)
REACT:R-BTA-193736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)
REACT:R-CFA-6811454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate PP2A (Canis familiaris)
REACT:R-CFA-167427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid dissociates from MOR (Canis familiaris)
REACT:R-DME-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Drosophila melanogaster)
REACT:R-SSC-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Sus scrofa)
RHEA:12091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP
RHEA:53084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP
RHEA:67740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-neuraminate = aceneuramate
REACT:R-XTR-3159259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAA:MUT binds AdoCbl (Xenopus tropicalis)
REACT:R-CFA-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Canis familiaris)
REACT:R-MTU-868709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Maltose is converted to trehalose (Mycobacterium tuberculosis)
RHEA:62146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dGDP => dGMP + dGTP
REACT:R-BTA-9008822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1D dephosphorylates RUNX2 (Bos taurus)
RHEA:64539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base
RHEA:14287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose
REACT:R-CEL-390427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Caenorhabditis elegans)
REACT:R-SSC-5610746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI3 (Sus scrofa)
GO:0103011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosylfructose-phosphate synthase activity
REACT:R-CFA-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Canis familiaris)
REACT:R-XTR-163820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Xenopus tropicalis)
REACT:R-CFA-6791235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds AURKA (Canis familiaris)
REACT:R-MMU-380574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine synaptic vesicle docking and priming (Mus musculus)
RHEA:40718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + hexadecanoyl-CoA <=> 1-hexadecanoylglycerone 3-phosphate + CoA
RHEA:43677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA
RHEA:62201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + 2 Fe(III)-[cytochrome c] => acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-RNO-3238999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Rattus norvegicus)
RHEA:54482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:50161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine
RHEA:69430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenic triglutathione + 3 H2O => arsenite + 3 glutathione + H(+)
REACT:R-CEL-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Caenorhabditis elegans)
REACT:R-CEL-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Caenorhabditis elegans)
GO:0005354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(in) = D-galactose(out)
GO:0005354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose transmembrane transporter activity
GO:0005354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose/glucose (methylgalactoside) porter activity
RHEA:43422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside diphosphate phosphatase activity
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside 5'-diphosphatase activity
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-diphosphatase activity
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	inosine 5'-diphosphatase
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type B nucleoside diphosphatase
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NDPase activity
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type L nucleoside diphosphatase
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside diphosphatase activity
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	apyrase activity
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside diphosphate phosphohydrolase activity
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	inosine diphosphatase
GO:0017110	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside-diphosphate phosphohydrolase activity
REACT:R-HSA-193497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Homo sapiens)
REACT:R-PFA-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Plasmodium falciparum)
REACT:R-CFA-2022398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Canis familiaris)
RHEA:29046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)
RHEA:30092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + D-alanine + H2O => a ubiquinol + NH4(+) + pyruvate
GO:0005174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40 receptor binding
RHEA:56321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose => an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP
REACT:R-HSA-6785668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective LARGE does not transfer Xyl from UDP-Xyl to GlcA (Homo sapiens)
RHEA:50762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + sulfate => a quinone + H2O + sulfite
RHEA:47014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + hydrogen sulfide
RHEA:72503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + prostaglandin F2alpha(out) = glutarate(out) + prostaglandin F2alpha(in)
REACT:R-HSA-9021406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 coactivator complex binds PBX1 gene promoter (Homo sapiens)
RHEA:10934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) => ATP + L-aspartate + L-citrulline
REACT:R-SPO-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Schizosaccharomyces pombe)
REACT:R-SSC-5686304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Sus scrofa)
RHEA:41609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha,alpha-trehalose => 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)
RHEA:13156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + CO2 + NAD(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine triphosphate-riboflavine mononucleotide transadenylase activity
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD diphosphorylase activity
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavine adenine dinucleotide adenylyltransferase activity
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin adenine dinucleotide pyrophosphorylase activity
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD pyrophosphorylase activity
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FAD synthetase activity
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	riboflavin mononucleotide adenylyltransferase activity
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:FMN adenylyltransferase activity
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavin adenine dinucleotide synthetase activity
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN adenylyltransferase activity
GO:0003919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine triphosphate-riboflavin mononucleotide transadenylase activity
REACT:R-CFA-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)
REACT:R-MMU-3076905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular BTD hydrolyses BCTN (Mus musculus)
REACT:R-HSA-9634402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer (Homo sapiens)
RHEA:47451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-SSC-450387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds the CRM1 nuclear export machinery (Sus scrofa)
REACT:R-PFA-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)
RHEA:23775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) <=> 2,3-dihydroxy-p-cumate + H(+) + NADH
REACT:R-SSC-5250938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Sus scrofa)
RHEA:40226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + H2O <=> 4,8-dimethylnonanoate + CoA + H(+)
REACT:R-BTA-2424481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
RHEA:34752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acyl-15-methylhexadecasphing-4-enine => ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate
RHEA:55808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:31558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-amino-3-oxohexanoate + acetyl-CoA <=> (3S)-3-aminobutanoyl-CoA + acetoacetate
REACT:R-BTA-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Bos taurus)
REACT:R-SSC-174446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap from the C-strand (Sus scrofa)
RHEA:12939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA
RHEA:10402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate + L-alanine => L-glutamine + pyruvate
RHEA:41604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
GO:0052622	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:ATP dimethylallyltransferase activity
GO:0052622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP dimethylallyltransferase activity
GO:0052622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP isopentenyltransferase activity
GO:0052622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopentenyl-diphosphate:ATP 2-isopentenyltransferase activity
GO:0052622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopentenyl-diphosphate:ATP delta2-isopentenyltransferase activity
GO:0050108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bornyl diphosphate hydrolase activity
GO:0050108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoterpenyl-diphosphatase activity
GO:0050108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bornyl pyrophosphate hydrolase activity
GO:0050108	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoterpenyl-diphosphate diphosphohydrolase activity
GO:0050108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoterpenyl-pyrophosphatase activity
REACT:R-CFA-390846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2D3,4 bind to DA (Canis familiaris)
RHEA:56641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-MMU-5696947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP47 deubiquitinates POLB (Mus musculus)
REACT:R-HSA-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Homo sapiens)
RHEA:65501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine
RHEA:69786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminophenyl)succinate + succinyl-CoA <=> 2-(2-aminophenyl)succinyl-CoA + succinate
REACT:R-CFA-9625813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P binds S1PR3 in response to E2 stimulation (Canis familiaris)
RHEA:68829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	borneol + NAD(+) => camphor + H(+) + NADH
REACT:R-BTA-9014294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the plasma membrane (Bos taurus)
RHEA:29999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type polyamine transporter"
RHEA:29999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + spermidine(out) = ADP + H(+) + phosphate + spermidine(in)
RHEA:29999	skos:altLabel	"polyamine ABC transporter"
RHEA:29999	skos:altLabel	"polyamine-transporting ATPase"
RHEA:29999	skos:prefLabel	"ABC-type polyamine transporter"
RHEA:13999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + CO2 + NADH => 3-methyl-2-oxobutanoate + CoA + NAD(+)
RHEA:63292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine
GO:0038149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCL2 receptor activity
GO:0038149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-C motif chemokine 2 receptor activity
REACT:R-SPO-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Schizosaccharomyces pombe)
RHEA:25410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha,alpha-trehalose + H(+) => ADP-alpha-D-glucose + D-glucose
REACT:R-SSC-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Sus scrofa)
GO:0015161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid III floppase activity
GO:0015161	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	capsule polysaccharide transporter activity
GO:0015161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	capsular polysaccharide transmembrane transporter activity
GO:0015161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	undecaprenol-pyrophosphate O-antigen flippase activity
RHEA:19907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrospermidine + H(+) + NADH => NAD(+) + spermidine
RHEA:42074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-2-oxoheptanedioate => (4Z)-2-oxohept-4-enedioate + H2O
REACT:R-MMU-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Mus musculus)
RHEA:23994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA
GO:0031956	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	medium-chain fatty acid activation
GO:0031956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	medium-chain fatty acid-CoA ligase activity
GO:0031956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	medium-chain-fatty-acid-CoA ligase activity
GO:0031956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	medium-chain fatty-acid-CoA ligase activity
REACT:R-CEL-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Caenorhabditis elegans)
REACT:R-BTA-1254248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80:YAP1 complex to the nucleus (Bos taurus)
RHEA:26430	skos:prefLabel	"phyllocladan-16alpha-ol synthase"
RHEA:26430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O = diphosphate + phyllocladan-16alpha-ol
RHEA:26430	skos:altLabel	"PaDC1"
RHEA:26430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phyllocladan-16alpha-ol synthase"
REACT:R-GGA-9604480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFkB complex translocates from the cytosol to the nucleus (Gallus gallus)
REACT:R-BTA-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Bos taurus)
REACT:R-DRE-9684627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds CYSLTR1 antagonists (Danio rerio)
RHEA:22311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + xylitol <=> D-xylose + H2O2
REACT:R-HSA-9636242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus (Homo sapiens)
RHEA:55375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl (-)-jasmonate <=> H(+) + jasmonate + methanol
REACT:R-DRE-83586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Danio rerio)
REACT:R-CFA-69562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Canis familiaris)
REACT:R-DME-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Drosophila melanogaster)
RHEA:44874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-GGA-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Gallus gallus)
REACT:R-MMU-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Mus musculus)
REACT:R-DDI-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)
REACT:R-DME-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Drosophila melanogaster)
RHEA:18282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + succinate => fumarate + H(+) + NADH
REACT:R-BTA-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Bos taurus)
RHEA:64454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine
RHEA:64374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O
RHEA:62330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-malbrancheamide + FADH2 => (+)-isomalbrancheamide B + chloride + FAD + 2 H(+)
RHEA:32877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + glycerol + H(+) => a 1-acyl-sn-glycerol + H2O
REACT:R-DRE-8875558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 binds CRK,CRKL (Danio rerio)
REACT:R-MMU-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Mus musculus)
RHEA:40229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A47934 + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + desulfo-A47934
REACT:R-DRE-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Danio rerio)
RHEA:40744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rd + 2 H2O => (20S)-ginsenoside C-K + 2 D-glucose
RHEA:71577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-N(alpha)-putrescinyl-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + putrescine
RHEA:37938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
RHEA:58807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-pApG-3' + H2O <=> 5'-ApG-3' + phosphate
GO:0051117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase binding
REACT:R-GGA-2990880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK6/NEK7 phosphorylates NUP98 (Gallus gallus)
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-GM2 galactosyltransferase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside galactosyltransferase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-ceramide galactosyltransferase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-GM2 galactosyltransferase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GM1-synthase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate D-galactose:glycolipid galactosyltransferase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose-GM2 ganglioside galactosyltransferase activity
GO:0047915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose-ceramide galactosyltransferase activity
REACT:R-CFA-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Canis familiaris)
REACT:R-XTR-1112690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds CBL (Xenopus tropicalis)
RHEA:20815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citryl-CoA <=> acetyl-CoA + oxaloacetate
RHEA:19122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted glutathione(in) + ATP + H2O => ADP + an S-substituted glutathione(out) + H(+) + phosphate
REACT:R-CEL-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Caenorhabditis elegans)
REACT:R-MMU-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Mus musculus)
RHEA:38357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA + H2O => (R)-3-phenyllactoyl-CoA
RHEA:17486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
REACT:R-HSA-9709663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 9b binds TOMM70 (Homo sapiens)
REACT:R-CFA-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Canis familiaris)
REACT:R-DRE-6785181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 bind LIPC dimer (Danio rerio)
REACT:R-SSC-1614605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is dioxygenated (Sus scrofa)
RHEA:66667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + coproporphyrin III(in) + H2O <=> ADP + coproporphyrin III(out) + H(+) + phosphate
REACT:R-MMU-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Mus musculus)
REACT:R-BTA-8950340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Bos taurus)
REACT:R-HSA-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Homo sapiens)
RHEA:45623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine
RHEA:72851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + AMP(in) = ADP(in) + AMP(out)
REACT:R-BTA-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Bos taurus)
REACT:R-SSC-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)
RHEA:34646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + squalene <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:44821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-13 + CO2 + diphosphate
REACT:R-HSA-9731632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)
REACT:R-DRE-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Danio rerio)
EC:3.4.21.72	skos:altLabel	"immunoglobulin A1 protease"
EC:3.4.21.72	skos:altLabel	"IgA protease"
EC:3.4.21.72	skos:prefLabel	"IgA-specific serine endopeptidase"
EC:3.4.21.72	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"IgA-specific serine endopeptidase"
REACT:R-XTR-9691421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK binds BTK inhibitors (Xenopus tropicalis)
GO:0047341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-fucose diphosphorylase activity
GO:0047341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-fucose pyrophosphorylase activity
GO:0047341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:fucose-1-phosphate guanylyltransferase activity
GO:0047341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphate L-fucose pyrophosphorylase activity
GO:0047341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP:beta-L-fucose-1-phosphate guanylyltransferase activity
GO:0047341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucose-1-phosphate guanylyltransferase activity
GO:0047341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-L-fucose pyrophosphorylase activity
GO:0047341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP fucose pyrophosphorylase activity
GO:0047341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP:L-fucose-1-phosphate guanylyltransferase activity
RHEA:61060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose = a neolactoside nLc4Cer + H(+) + UDP
RHEA:39084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanedioyl-CoA + CoA => acetyl-CoA + decanedioyl-CoA
GO:0033608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyl-coenzyme A transferase activity
GO:0033608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyl-CoA:oxalate CoA-transferase activity
GO:0033608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyl-CoA transferase activity
GO:0033608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyl-CoA oxalate CoA-transferase activity
REACT:R-HSA-199131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR binds CD226 (Homo sapiens)
REACT:R-SSC-5246478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOM binds retinoids (Sus scrofa)
GO:0070644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin D response element binding
GO:0070644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDRE binding
REACT:R-XTR-5626953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds DENN/MADD (Xenopus tropicalis)
RHEA:26431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O => diphosphate + phyllocladan-16alpha-ol
REACT:R-XTR-2032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ), TBX5, and PCAF form a complex (Xenopus tropicalis)
RHEA:41134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-decanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)
REACT:R-SSC-6801675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates NPM1 (Sus scrofa)
GO:0047202	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity
GO:0047202	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sinapine synthase activity
GO:0047202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapoylglucose-choline O-sinapoyltransferase activity
REACT:R-CFA-1433428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2 is indirectly recruited to p-KIT through SHP2 (Canis familiaris)
REACT:R-XTR-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Xenopus tropicalis)
REACT:R-DRE-8852266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Danio rerio)
REACT:R-HSA-5693055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)
REACT:R-DRE-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Danio rerio)
RHEA:53943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5654147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PLCG1 (Mus musculus)
RHEA:19578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin + UDP-alpha-D-glucose => H(+) + luteolin 7-O-beta-D-glucoside + UDP
REACT:R-RNO-5323545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canonical WNT signaling through the atypical receptor RYK (Rattus norvegicus)
RHEA:33616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + octadecanoate => AMP + diphosphate + octadecanoyl-CoA
RHEA:21130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fecosterol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + zymosterol
REACT:R-XTR-8948230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P3HB binds 4-Hyp-collagen propeptides (Xenopus tropicalis)
REACT:R-HSA-8865107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MICAL1 produces NADP+, H2O2 (Homo sapiens)
REACT:R-HSA-549533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PERIOD-1 (Homo sapiens)
REACT:R-HSA-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Homo sapiens)
GO:0052902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
GO:0052902	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N(1)-acetylpolyamine oxidase activity
GO:0052902	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	non-specific polyamine oxidase activity
GO:0052902	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyamine oxidase activity
REACT:R-MMU-165026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Mus musculus)
RHEA:54699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate
RHEA:14788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA(n) + UTP <=> diphosphate + RNA(n)-3'-uridine ribonucleotide
RHEA:34901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA methyl ester + S-adenosyl-L-homocysteine => malonyl-CoA + S-adenosyl-L-methionine
RHEA:29203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + menaquinol-8 = dimethyl sulfide + H2O + menaquinone-8
RHEA:56560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP
REACT:R-MMU-8853789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDNF,NRTN bind RET:GFRA1,GFRA2 (Mus musculus)
EC:3.4.24.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bacillolysin"
EC:3.4.24.28	skos:altLabel	"megateriopeptidase"
EC:3.4.24.28	skos:altLabel	"Bacillus subtilis neutral proteinase"
EC:3.4.24.28	skos:prefLabel	"bacillolysin"
EC:3.4.24.28	skos:altLabel	"Bacillus metalloendopeptidase"
REACT:R-DRE-162730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Danio rerio)
REACT:R-XTR-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Xenopus tropicalis)
RHEA:39319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)
RHEA:10167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate <=> H2O + phosphoenolpyruvate
GO:0043960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythro-3-methylmalyl-CoA dehydratase activity
REACT:R-CFA-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)
RHEA:44578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-nonaprenylphenol + CO2 => 4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+)
REACT:R-SSC-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Sus scrofa)
REACT:R-XTR-2314678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS1 (Xenopus tropicalis)
REACT:R-BTA-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Bos taurus)
REACT:R-CEL-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Caenorhabditis elegans)
RHEA:55649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + validoxylamine A => CO2 + H(+) + succinate + validoxylamine B
REACT:R-CFA-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Canis familiaris)
RHEA:59413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuccinamate + H2O => NH4(+) + oxaloacetate
REACT:R-MMU-351894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of BAP31 (Mus musculus)
RHEA:66523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)
RHEA:13179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + dihydroxyacetone phosphate => 6-phospho-5-dehydro-2-deoxy-D-gluconate
REACT:R-PFA-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Plasmodium falciparum)
REACT:R-DRE-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)
REACT:R-MMU-202375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ITK to SLP-76 (Mus musculus)
RHEA:39526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O
REACT:R-RNO-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Rattus norvegicus)
RHEA:14440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + O2 <=> 6-amino-2-oxohexanoate + H2O2 + NH4(+)
RHEA:40683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol = 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate
RHEA:62546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroouabagenin + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin
REACT:R-SSC-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Sus scrofa)
RHEA:59666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellopentaono-1,5-lactone + H2O2 => D-cellopentaose + O2
REACT:R-GGA-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Gallus gallus)
GO:0033997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity
GO:0033997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity
GO:0033997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity
GO:0033997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inulin fructotransferase (DFA-I-forming) activity
GO:0033997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inulin fructotransferase (DFA-I-producing) activity
GO:0033997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity
RHEA:23697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + O2 => D-glucuronate + H(+) + H2O
RHEA:34075	skos:altLabel	"glycerol-3-phosphate acyltransferase (acyl-phosphate transferring)"
RHEA:34075	skos:altLabel	"GPAT"
RHEA:34075	skos:altLabel	"LPA synthase"
RHEA:34075	skos:altLabel	"lysophosphatidic acid synthase"
RHEA:34075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl phosphate:glycerol-3-phosphate acyltransferase"
RHEA:34075	skos:altLabel	"acyl-phosphate--glycerol-3-phosphate acyltransferase"
RHEA:34075	skos:altLabel	"G3P acyltransferase"
RHEA:34075	skos:altLabel	"acyl-PO4 G3P acyltransferase"
RHEA:34075	skos:prefLabel	"acyl phosphate:glycerol-3-phosphate acyltransferase"
RHEA:34075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate
RHEA:10211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) <=> H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)
RHEA:72738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) <=> UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)
REACT:R-BTA-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Bos taurus)
REACT:R-HSA-5663271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors (Homo sapiens)
REACT:R-HSA-1602488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by plasmin and trypsin (Homo sapiens)
REACT:R-DDI-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Dictyostelium discoideum)
RHEA:18273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + putrescine = 4-aminobutanal + H2O2 + NH4(+)
RHEA:18273	skos:prefLabel	"putrescine oxidase"
RHEA:18273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"putrescine oxidase"
REACT:R-HSA-9013284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3-ligand complex is cleaved to produce NEXT3 (Homo sapiens)
REACT:R-BTA-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Bos taurus)
REACT:R-CEL-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
RHEA:63007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienamide + H2O <=> (11Z,14Z)-eicosadienoate + NH4(+)
RHEA:59188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histidine racemase"
RHEA:59188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine = D-histidine
RHEA:59188	skos:prefLabel	"histidine racemase"
GO:0080096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidate-sterol O-acyltransferase activity
RHEA:50613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanal + NADP(+) => (2E)-decenal + H(+) + NADPH
REACT:R-RNO-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Rattus norvegicus)
REACT:R-MMU-1169403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 ligase with ISG15:E2 complex (Mus musculus)
RHEA:44769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2
EC:1.5.99.-	skos:prefLabel	"With other acceptors"
EC:1.5.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
REACT:R-HSA-5624494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 binds p21 RAS:GTP (Homo sapiens)
REACT:R-BTA-8848110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds activated PTK6 (Bos taurus)
RHEA:31569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+) => bisphenol A + H(+) + NADH + O2
RHEA:39950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)
RHEA:57565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-6792712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at shortened telomeres (Saccharomyces cerevisiae)
GO:0004798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidylic kinase activity
GO:0004798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine 5'-monophosphate kinase activity
GO:0004798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidylic acid kinase activity
GO:0004798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTMP kinase activity
GO:0004798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TMPK activity
GO:0004798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidylate kinase activity
GO:0004798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine monophosphate kinase activity
GO:0004798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxythymidine 5'-monophosphate kinase activity
GO:0004798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:dTMP phosphotransferase activity
GO:0004798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidylate monophosphate kinase activity
GO:0071568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UFM1 transferase activity
RHEA:70669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein] => a fatty acyl-[ACP] + L-lysyl-[protein]
RHEA:39602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)
RHEA:59960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha)-acetyl-D-methionine = N(alpha)-acetyl-L-methionine
REACT:R-HSA-9018505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive EBAG9 gene expression (Homo sapiens)
REACT:R-HSA-2065233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CS is cleaved from its proteoglycan (Homo sapiens)
REACT:R-GGA-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Gallus gallus)
REACT:R-HSA-9038163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Homo sapiens)
REACT:R-DRE-450292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Danio rerio)
REACT:R-RNO-8876283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Rattus norvegicus)
RHEA:58847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeranial + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH
GO:0047476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity
GO:0047476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)
GO:0047476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity
GO:0047476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHCA-CoA ligase activity
GO:0047476	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity
REACT:R-GGA-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Gallus gallus)
REACT:R-XTR-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Xenopus tropicalis)
GO:0140135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanosensitive cation channel activity
GO:0140135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mechanically-gated cation channel activity
REACT:R-DRE-158781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Danio rerio)
RHEA:41695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)
RHEA:31009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin => (S)-2,3-epoxysqualene
REACT:R-CFA-5362441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Canis familiaris)
RHEA:10876	skos:prefLabel	"4-hydroxybenzoate decarboxylase"
RHEA:10876	skos:altLabel	"p-hydroxybenzoate decarboxylase"
RHEA:10876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoate decarboxylase"
RHEA:10876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + H(+) = CO2 + phenol
RHEA:10876	skos:altLabel	"4-hydroxybenzoate carboxy-lyase"
GO:0001856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C5a binding
GO:0018573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminophenol 1,6-dioxygenase activity
REACT:R-DME-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)
REACT:R-HSA-8943987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCUBE1, SCUBE3 oligomerize (Homo sapiens)
RHEA:40781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-aminopentanoate + NH4(+) => 2-aminopentanenitrile + H(+) + 2 H2O
RHEA:16070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + H(+) + H2O => NH4(+) + uridine
REACT:R-HSA-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Homo sapiens)
REACT:R-BTA-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Bos taurus)
REACT:R-XTR-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Xenopus tropicalis)
RHEA:31075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O
REACT:R-HSA-9669906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of KIT juxtamembrane domain mutants (Homo sapiens)
REACT:R-GGA-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
RHEA:40588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanedioyl-CoA => CoA + H(+) + octanedioate
RHEA:25500	skos:prefLabel	"terpinolene synthase"
RHEA:25500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = diphosphate + terpinolene
RHEA:25500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"terpinolene synthase"
REACT:R-HSA-193715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)
REACT:R-CEL-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Caenorhabditis elegans)
RHEA:57714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP => (E)-sinapaldehyde + UDP-alpha-D-glucose
GO:0003696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	satellite DNA binding
REACT:R-CEL-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)
REACT:R-XTR-430021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAN2-PAN3 complex partially deadenylates mRNA (Xenopus tropicalis)
REACT:R-CFA-3465429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)
RHEA:15307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + 2 H(+) + NADH => betaine aldehyde + H2O + NAD(+)
RHEA:53504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-hydroxybenzimidazole synthase"
RHEA:53504	skos:prefLabel	"5-hydroxybenzimidazole synthase"
RHEA:53504	skos:altLabel	"HBI synthase"
RHEA:53504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate
RHEA:68653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-homocysteine => H(+) + hydrogen sulfide + L-homolanthionine
REACT:R-DME-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Drosophila melanogaster)
RHEA:68637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => diphosphate + sabinene
REACT:R-HSA-2399996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates CREB1 (Homo sapiens)
REACT:R-HSA-1861621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIA with IgG-coated Ag (Homo sapiens)
REACT:R-XTR-5689649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds BRCA1:BARD1 (Xenopus tropicalis)
RHEA:42900	skos:altLabel	"23S rRNA m(1)G(745) methyltransferase"
RHEA:42900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(745) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:42900	skos:prefLabel	"23S rRNA (guanine(745)-N(1))-methyltransferase"
RHEA:42900	skos:altLabel	"ribosomal RNA(m(1)G)-methylase"
RHEA:42900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (guanine(745)-N(1))-methyltransferase"
RHEA:25279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) => 3',5'-cyclic AMP + H2O
RHEA:14537	skos:prefLabel	"pyrithiamine deaminase"
RHEA:14537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)
RHEA:14537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrithiamine deaminase"
RHEA:20797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose => D-ribulose
RHEA:11707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N-(carboxyaminomethyl)urea <=> CO2 + N-(aminomethyl)urea
REACT:R-HSA-9708525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1:FBXL17 binds SCF(SKP2) complex (Homo sapiens)
REACT:R-CFA-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Canis familiaris)
REACT:R-BTA-2161959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Bos taurus)
REACT:R-SSC-8987105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)
GO:0047996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyphytanate oxidase activity
GO:0047996	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-2-hydroxyphytanate:oxygen 2-oxidoreductase
REACT:R-MMU-8964634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Mus musculus)
REACT:R-RNO-9707051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)
RHEA:29590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH
RHEA:19872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + glycine <=> an N-acylglycine + CoA + H(+)
REACT:R-GGA-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Gallus gallus)
EC:1.97.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other oxidoreductases"
EC:1.97.-.-	skos:prefLabel	"Other oxidoreductases"
RHEA:19333	skos:prefLabel	"oxalyl-CoA decarboxylase"
RHEA:19333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxalyl-CoA decarboxylase"
RHEA:19333	skos:altLabel	"oxalyl-CoA carboxy-lyase"
RHEA:19333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxalyl-CoA = CO2 + formyl-CoA
REACT:R-DRE-2294600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates condensin II subunit NCAPD3 (Danio rerio)
REACT:R-CFA-187828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p21 to the nucleus (Canis familiaris)
REACT:R-DRE-917839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-Transferrin dissociates from the receptor complex (Danio rerio)
REACT:R-SSC-5623519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP and RAB8A bind to the ciliary targeting complex (Sus scrofa)
RHEA:68013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hypoxanthine + O2 => H2O2 + xanthine
REACT:R-HSA-9686345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer (Homo sapiens)
EC:1.18.1.1	skos:prefLabel	"rubredoxin--NAD(+) reductase"
EC:1.18.1.1	skos:altLabel	"reduced nicotinamide adenine dinucleotide-rubredoxin reductase"
EC:1.18.1.1	skos:altLabel	"NADH-rubredoxin oxidoreductase"
EC:1.18.1.1	skos:altLabel	"NADH-rubredoxin reductase"
EC:1.18.1.1	skos:altLabel	"rubredoxin-NAD reductase"
EC:1.18.1.1	skos:altLabel	"rubredoxin reductase"
EC:1.18.1.1	skos:altLabel	"rubredoxin-nicotinamide adenine dinucleotide reductase"
EC:1.18.1.1	skos:altLabel	"dihydronicotinamide adenine dinucleotide-rubredoxin reductase"
EC:1.18.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rubredoxin--NAD(+) reductase"
RHEA:13644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methane + NADPH + O2 <=> H2O + methanol + NADP(+)
GO:0015133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uronic acid transmembrane transporter activity
GO:0015330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity glutamine transmembrane transporter activity
GO:0015330	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	high affinity glutamine permease activity
GO:0015330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity glutamine transmembrane transporter activity
REACT:R-PFA-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Plasmodium falciparum)
REACT:R-BTA-266303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds C and E apolipoproteins (Bos taurus)
RHEA:12923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate + CO2 + CoA => glycine + H(+) + succinyl-CoA
REACT:R-DDI-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Dictyostelium discoideum)
RHEA:54278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2
GO:0004055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine succinate synthetase activity
GO:0004055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate synthase activity
GO:0004055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	argininosuccinic acid synthetase activity
GO:0004055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrulline--aspartate ligase activity
GO:0004055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-citrulline:L-aspartate ligase (AMP-forming)
GO:0004055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginosuccinate synthetase activity
GO:0004055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	argininosuccinate synthetase activity
RHEA:14963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + glutathione + H(+) => H2O + S-formylglutathione
RHEA:13552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-fucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-beta-L-fucose
RHEA:67215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 <=> (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2
GO:1990043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' deoxyribonuclease (pyrimidine dimer) activity
RHEA:53089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Mus musculus)
REACT:R-CFA-5669012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA binds EDAR (Canis familiaris)
REACT:R-BTA-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Bos taurus)
REACT:R-MMU-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Mus musculus)
REACT:R-SSC-77299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Sus scrofa)
RHEA:32713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxoacyl-CoA + H(+) + NADH => a (3R)-3-hydroxyacyl-CoA + NAD(+)
RHEA:50987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E2(out) <=> prostaglandin E2(in)
REACT:R-MMU-5675373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear DUSPs dephosphorylate MAPKs (Mus musculus)
REACT:R-CEL-8862380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B13 binds lipid droplets (Caenorhabditis elegans)
REACT:R-DRE-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Danio rerio)
RHEA:20508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-(gamma-L-glutamyl)-L-amino acid <=> 5-oxo-L-proline + an L-alpha-amino acid
REACT:R-HSA-168935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viral dsRNA binds DDX58 (Homo sapiens)
RHEA:57122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
REACT:R-GGA-2213208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type X collagen associates with collagen type II fibrils (Gallus gallus)
REACT:R-RNO-202472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TRAF6 to CBM complex (Rattus norvegicus)
RHEA:16828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + uridine <=> ADP + H(+) + UMP
REACT:R-BTA-8851436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFHR dimers bind C3b (Bos taurus)
RHEA:57994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside C-K + UDP-alpha-D-glucose
RHEA:35557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid => cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]
GO:0005152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1 receptor antagonist activity
GO:0005152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-1ra
GO:1902417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity
GO:1902417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABA-GE transmembrane transporter activity
GO:1902417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisic acid glucosyl ester transmembrane transporter activity
RHEA:54430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-ribose + H(+) + L-aspartyl-[protein] => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O
REACT:R-CFA-5624956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds INPP5E (Canis familiaris)
GO:0015454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	light-driven pumps
GO:0015454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	light absorption-driven transporter
GO:0015454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	light-driven active ion transmembrane transporter activity
GO:0015454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	light-driven active transmembrane transporter activity
REACT:R-CFA-445753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Canis familiaris)
GO:0102740	skos:altLabel	"dimethylxanthine methyltransferase"
GO:0102740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caffeine synthase"
GO:0102740	skos:prefLabel	"caffeine synthase"
GO:0102740	skos:altLabel	"3N-methyltransferase"
GO:0102740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity
REACT:R-XTR-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Xenopus tropicalis)
RHEA:52151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose <=> an aliphatic (Z)-desulfo-glucosinolate + UDP
RHEA:22116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase"
RHEA:22116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP
RHEA:22116	skos:prefLabel	"luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase"
REACT:R-CFA-9624017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SHC1 binds integrin alpha5beta1:fibronectin (Canis familiaris)
RHEA:52027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> 18S-resolvin E2 + A + H2O
REACT:R-HSA-167128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)
RHEA:64349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) => deacetylpyripyropene E
RHEA:64466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + L-topaquinyl-[protein] => L-tyrosyl-[protein] + 2 O2
REACT:R-SSC-9022314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates MECP2 (Sus scrofa)
RHEA:20315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP
RHEA:16454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O => 2-formylbenzoate + pyruvate
RHEA:29707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-anhydro-N-acetyl-beta-muramate(in) = 1,6-anhydro-N-acetyl-beta-muramate(out)
REACT:R-CEL-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)
REACT:R-HSA-4420099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHB  (Homo sapiens)
REACT:R-HSA-8950344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of BolA-like protein 2 (Homo sapiens)
RHEA:12268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + putrescine = 1-pyrroline + H2O + L-glutamate
REACT:R-HSA-9026780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)
RHEA:25294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH
REACT:R-XTR-2471842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XXV ectomain shedding (Xenopus tropicalis)
REACT:R-RNO-374758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Somatostatin receptors bind somatostatin and cortistatin (Rattus norvegicus)
REACT:R-CFA-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Canis familiaris)
REACT:R-SCE-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Saccharomyces cerevisiae)
REACT:R-RNO-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Rattus norvegicus)
GO:0045157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity
GO:0045157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome
GO:1904767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octanoic acid binding
GO:1904767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caprylic acid binding
REACT:R-DRE-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Danio rerio)
REACT:R-MMU-8934742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRMT1 (Mus musculus)
RHEA:40770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside R1 + H2O <=> (20S)-ginsenoside Rg1 + D-xylose
REACT:R-RNO-913451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3RB is phosphorylated on Ser-585 (Rattus norvegicus)
RHEA:41451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-isoleucine + O2 <=> (4S)-4-hydroxy-L-isoleucine + CO2 + succinate
REACT:R-BTA-418856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 (Bos taurus)
REACT:R-BTA-1006169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds host cell surface markers (Bos taurus)
REACT:R-GGA-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Gallus gallus)
REACT:R-CFA-5244669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Canis familiaris)
RHEA:36358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine
REACT:R-DRE-5682983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates WHSC1 (Danio rerio)
REACT:R-DRE-3928612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KALRN exchanges GTP for GDP on RAC1, activating it (Danio rerio)
GO:0015529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raffinose:hydrogen symporter activity
GO:0015529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raffinose:proton symporter activity
REACT:R-SPO-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Schizosaccharomyces pombe)
RHEA:55743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oleuropein <=> D-glucose + oleuropein aglycone
REACT:R-BTA-5218642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Bos taurus)
REACT:R-HSA-2064417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-1 (TJP1) (Homo sapiens)
REACT:R-BTA-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Bos taurus)
REACT:R-DDI-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Dictyostelium discoideum)
REACT:R-BTA-8950780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 binds p-Y693-STAT4 (Bos taurus)
RHEA:42950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA + S-adenosyl-L-methionine
REACT:R-DME-5674496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate MAP2K1 (Drosophila melanogaster)
REACT:R-DDI-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Dictyostelium discoideum)
RHEA:41713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)
REACT:R-MMU-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Mus musculus)
REACT:R-BTA-73757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RRN3 to RNA Polymerase I (Bos taurus)
REACT:R-DRE-5362448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh C-terminal fragments are degraded by the proteasome (Danio rerio)
REACT:R-DME-193727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
RHEA:21642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH => NADP(+) + prephenate
EC:3.4.22.37	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gingipain R"
EC:3.4.22.37	skos:altLabel	"gingipain-1"
EC:3.4.22.37	skos:prefLabel	"gingipain R"
EC:3.4.22.37	skos:altLabel	"Arg-gingipain"
EC:3.4.22.37	skos:altLabel	"argingipain"
REACT:R-BTA-400071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Bos taurus)
RHEA:34188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate
REACT:R-SSC-9627089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP9 is phosphorylated at T125 (Sus scrofa)
RHEA:22619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 sulochrin <=> 2 (2R)-bisdechlorogeodin + 2 H2O
RHEA:65740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + nonyl sufate + O2 = CO2 + H(+) + nonanal + succinate + sulfate
REACT:R-MMU-9029561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to the ABCA1 promoter (Mus musculus)
RHEA:66397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholate(in) + glutathione(in) + H2O => ADP + cholate(out) + glutathione(out) + H(+) + phosphate
REACT:R-GGA-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Gallus gallus)
GO:0042498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacyl lipopeptide binding
GO:0042498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylated lipopeptide binding
GO:0042498	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial diacyl lipopeptide binding
GO:0042498	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bacterial diacyl lipoprotein binding
RHEA:66779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + uroporphyrin III(in) <=> ADP + H(+) + phosphate + uroporphyrin III(out)
REACT:R-GGA-6788622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs dimerize (Gallus gallus)
REACT:R-CEL-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Caenorhabditis elegans)
GO:0008995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease E activity
REACT:R-HSA-6800380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAP-1 (Homo sapiens)
REACT:R-RNO-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Rattus norvegicus)
RHEA:11631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H(+) <=> an aldehyde + CO2
RHEA:13072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + ethanolamine <=> ADP + H(+) + phosphoethanolamine
RHEA:41066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:38075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA
RHEA:44400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-6 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-6
REACT:R-HSA-9017817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-secretase cleaves YBX1:NOTCH3 (Homo sapiens)
REACT:R-BTA-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Bos taurus)
REACT:R-SSC-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Sus scrofa)
EC:3.4.22.64	skos:altLabel	"CASP-11"
EC:3.4.22.64	skos:prefLabel	"caspase-11"
EC:3.4.22.64	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-11"
REACT:R-DME-6799409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates TP53 (Drosophila melanogaster)
REACT:R-DRE-9018499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and EP300 are recruited to TFF3 promoter (Danio rerio)
RHEA:14489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H(+)
RHEA:21242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] => geranylgeranyl diphosphate + L-cysteinyl-[protein]
RHEA:63865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + octadecanoate => (2R)-2-hydroperoxyoctadecanoate
RHEA:27954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"presilphiperfolanol synthase"
RHEA:27954	skos:prefLabel	"presilphiperfolanol synthase"
RHEA:27954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = diphosphate + presilphiperfolan-8beta-ol
REACT:R-CEL-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Caenorhabditis elegans)
RHEA:60283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:51599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:27678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dCDP = ADP + dCTP
REACT:R-DRE-4551738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO2,3 (Danio rerio)
REACT:R-SSC-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Sus scrofa)
REACT:R-DME-1602446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Drosophila melanogaster)
REACT:R-XTR-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Xenopus tropicalis)
RHEA:53535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate <=> (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O
REACT:R-RNO-977301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histidine is decarboxylated to histamine (Rattus norvegicus)
REACT:R-RNO-180047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates DARPP-32 on Thr75 (Rattus norvegicus)
REACT:R-XTR-5423653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGST trimers transfer GS from GSH to AFXBO and AFNBO (Xenopus tropicalis)
RHEA:25767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2-oxobutanoate + H(+) = 2-oxobutanoate + CO2
REACT:R-CFA-5654157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR2 (Canis familiaris)
RHEA:35404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) => (3R)-vestitone + H(+) + NADPH
RHEA:48179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0102941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dihydroxyanisole O-methyltransferase activity
REACT:R-BTA-5696197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Bos taurus)
GO:0106140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-TEFb complex binding
REACT:R-XTR-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)
REACT:R-HSA-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Homo sapiens)
RHEA:11397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyldeoxycytidine 5'-phosphate + ATP => 5-methyldeoxycytidine diphosphate + ADP
REACT:R-DRE-191072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Cx43 (Danio rerio)
REACT:R-DRE-388605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMC(138-176) binds MC2R (Danio rerio)
REACT:R-HSA-9625406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3 bind KLF4 gene promoter (Homo sapiens)
REACT:R-BTA-6793666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the nucleus (Bos taurus)
RHEA:41049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol
REACT:R-BTA-1535903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Bos taurus)
REACT:R-SSC-5685319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex formation (Sus scrofa)
REACT:R-RNO-171141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Rattus norvegicus)
REACT:R-RNO-3215426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Rattus norvegicus)
RHEA:46743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrodesmosterol + H(+) + NADPH <=> desmosterol + NADP(+)
REACT:R-SCE-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Saccharomyces cerevisiae)
RHEA:12986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
REACT:R-HSA-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Homo sapiens)
RHEA:43414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + D-galactose => a D-galactosylceramide + H2O
RHEA:61253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-valine + O2 => 3-methyl-2-oxobutanoate + H2O2 + NH4(+)
GO:0102838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity
RHEA:35390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-7 + S-adenosyl-L-methionine <=> 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine
REACT:R-CFA-1638803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)
REACT:R-SSC-5685605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF7 binds SLAMF7 (Sus scrofa)
REACT:R-DRE-3781018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Danio rerio)
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	crotonyl hydrase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl hydrase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	enoyl coenzyme A hydrase (D)
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ECH
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-3-hydroxyacyl-CoA dehydratase
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enol-CoA hydratase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl coenzyme A hydrase (L)
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-octenoyl coenzyme A hydrase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl coenzyme A hydratase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyacyl-CoA dehydrase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-CoA hydratase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl coenzyme A hydrase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydratase, enoyl coenzyme A
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-3-hydroxyacyl-CoA hydro-lyase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short chain enoyl coenzyme A hydratase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-enoyl-CoA hydratase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	short-chain enoyl-CoA hydratase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyacid dehydrase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	unsaturated acyl-CoA hydratase activity
GO:0004300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-2-enoyl-CoA hydratase activity
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	water pyruvate dikinase activity
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate-water dikinase (phosphorylating)
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate, water dikinase activity
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvic synthase activity
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEP synthetase activity
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate,water dikinase activity
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate synthetase activity
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phoephoenolpyruvate synthetase activity
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate synthase activity
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:pyruvate, water phosphotransferase activity
GO:0008986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEP synthase activity
REACT:R-HSA-110172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences (Homo sapiens)
REACT:R-SSC-9606894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DAPP1 (p-BAM32) binds PLCG2 (Sus scrofa)
REACT:R-HSA-451377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IQGAP1 with nephrin (Homo sapiens)
RHEA:13785	skos:prefLabel	"itaconyl-CoA hydratase"
RHEA:13785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"itaconyl-CoA hydratase"
RHEA:13785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA = H2O + itaconyl-CoA
RHEA:65566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine => (9Z)-octadecenoyl-CoA + H2O
RHEA:34944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) => arbutin 6-phosphate(in) + pyruvate(in)
REACT:R-HSA-9682563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)
REACT:R-SSC-975040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAB-ZNF / KAP Interaction (Sus scrofa)
REACT:R-DRE-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Danio rerio)
RHEA:34212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecgonine methyl ester + NADP(+) => ecgonone methyl ester + H(+) + NADPH
REACT:R-SCE-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
RHEA:28513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arbutin 6-phosphate + H2O <=> beta-D-glucose 6-phosphate + hydroquinone
RHEA:20408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + acetate
RHEA:70014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzoyl-AMP + CoA <=> AMP + anthraniloyl-CoA + H(+)
RHEA:72354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + glycocholate(out) <=> glutarate(out) + glycocholate(in)
GO:0031755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA1 receptor binding
GO:0031755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edg-2 lysophosphatidic acid receptor binding
GO:0031755	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Edg-2 lysophosphatidic acid receptor ligand
REACT:R-DME-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Drosophila melanogaster)
RHEA:33650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + ATP + CoA <=> (9Z)-hexadecenoyl-CoA + AMP + diphosphate
REACT:R-XTR-2022379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Xenopus tropicalis)
REACT:R-SSC-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Sus scrofa)
RHEA:15266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate => H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate
REACT:R-DRE-1963563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Danio rerio)
RHEA:63762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
REACT:R-CEL-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
RHEA:63019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)
RHEA:44878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a fatty acid + H(+) => a 1,3-diacylglycerol + H2O
REACT:R-HSA-8848596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds PXN (Homo sapiens)
REACT:R-CFA-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Canis familiaris)
RHEA:71286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-glutamine(out) + 2 Na(+)(out) <=> chloride(in) + L-glutamine(in) + 2 Na(+)(in)
REACT:R-PFA-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Plasmodium falciparum)
RHEA:31911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1,6-bisphosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate
EC:3.2.1.152	skos:altLabel	"endo-beta-mannosidase"
EC:3.2.1.152	skos:prefLabel	"mannosylglycoprotein endo-beta-mannosidase"
EC:3.2.1.152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosylglycoprotein endo-beta-mannosidase"
REACT:R-RNO-9034053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Rattus norvegicus)
REACT:R-MMU-5654408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS2 (Mus musculus)
RHEA:65702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CEL-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Caenorhabditis elegans)
REACT:R-HSA-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Homo sapiens)
RHEA:17498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formononetin + UDP-alpha-D-glucose => ononin + UDP
RHEA:20515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-arylpropionate + CO2 => 2-aryl-2-methylmalonate + H(+)
REACT:R-PFA-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Plasmodium falciparum)
REACT:R-DRE-3965450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits PFN1 (Danio rerio)
GO:0016515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-13 receptor activity
GO:0016515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-13R
GO:0016515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-13 receptor activity
REACT:R-SSC-1470012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus (Sus scrofa)
REACT:R-HSA-9621400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2 and SREBF2 dimer bind SCD5 gene (Homo sapiens)
REACT:R-CFA-201486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand pleiotrophin (PTN) (Canis familiaris)
REACT:R-RNO-418858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoGTPase GEF's recruited to DCC (Rattus norvegicus)
REACT:R-SSC-453339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)
REACT:R-BTA-201717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK2-mediated phosphorylation of DVL (Bos taurus)
REACT:R-PFA-4570489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO2 (Plasmodium falciparum)
RHEA:46499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)
REACT:R-HSA-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Homo sapiens)
REACT:R-CFA-9707504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 oxidises ferrohemoglobin to MetHb (Canis familiaris)
REACT:R-GGA-6784204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind OSMR (Gallus gallus)
RHEA:43204	skos:prefLabel	"16S rRNA (cytidine(1409)-2'-O)-methyltransferase"
RHEA:43204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (cytidine(1409)-2'-O)-methyltransferase"
RHEA:43204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
GO:0106375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxynucleoside triphosphate hydrolase activity
GO:0106375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + H(+) + triphosphate
REACT:R-MMU-163664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binds to gamma subunit of AMP kinase heterotrimer (Mus musculus)
EC:2.5.1.148	skos:prefLabel	"lycopaoctaene synthase"
EC:2.5.1.148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lycopaoctaene synthase"
REACT:R-DDI-4568848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Dictyostelium discoideum)
REACT:R-MMU-8938773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A polyubiquitinates PRKDC (Mus musculus)
REACT:R-SSC-194023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2,HSD11B1 dimer oxidise CORT to COR (Sus scrofa)
GO:0044466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA hydrolase activity
GO:0044466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA thioesterase activity
REACT:R-HSA-5696997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP24 deubiquitinates DDB2 (Homo sapiens)
REACT:R-GGA-2002428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen N-propeptides (Gallus gallus)
REACT:R-MMU-2730904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Mus musculus)
EC:3.2.1.23	skos:altLabel	"exo-(1->4)-beta-D-galactanase"
EC:3.2.1.23	skos:altLabel	"lactase"
EC:3.2.1.23	skos:prefLabel	"beta-galactosidase"
EC:3.2.1.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-galactosidase"
REACT:R-DRE-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Danio rerio)
REACT:R-SPO-6782224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' incision by ERCC5 (XPG) in TC-NER (Schizosaccharomyces pombe)
REACT:R-SPO-5696091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Schizosaccharomyces pombe)
REACT:R-PFA-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Plasmodium falciparum)
RHEA:49017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C epoxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one
REACT:R-PFA-727807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A1 exchanges CMP-Neu5Ac for CMP (Plasmodium falciparum)
REACT:R-SSC-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Sus scrofa)
REACT:R-BTA-373074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR9  binds CCL25 ligand (Bos taurus)
RHEA:28245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + pratensein + reduced [NADPH--hemoprotein reductase] <=> 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-2130151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of DAP12 (Danio rerio)
REACT:R-HSA-166362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
RHEA:39597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH
RHEA:10203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate + NAD(+) <=> (2E)-2-butenoate + H(+) + NADH
RHEA:10096	skos:altLabel	"autoinducer synthesis protein"
RHEA:10096	skos:altLabel	"acyl-homoserine lactone synthase"
RHEA:10096	skos:prefLabel	"acyl-homoserine-lactone synthase"
RHEA:10096	skos:altLabel	"acyl homoserine lactone synthase"
RHEA:10096	skos:altLabel	"AHSL synthase"
RHEA:10096	skos:altLabel	"autoinducer synthase"
RHEA:10096	skos:altLabel	"acyl-homoserinelactone synthase"
RHEA:10096	skos:altLabel	"N-acyl homoserine lactone synthase"
RHEA:10096	skos:altLabel	"acylhomoserine lactone synthase"
RHEA:10096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine
RHEA:10096	skos:altLabel	"AHL synthase"
RHEA:10096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-homoserine-lactone synthase"
REACT:R-HSA-8864307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Homo sapiens)
REACT:R-SPO-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Schizosaccharomyces pombe)
RHEA:61633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanal + H2O + NAD(+) => 5-aminopentanoate + 2 H(+) + NADH
RHEA:21979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite <=> [thioredoxin]-dithiol + adenosine 5'-phosphosulfate
GO:0050008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopiperitenone D-isomerase activity
GO:0050008	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopiperitenone delta8-delta4-isomerase activity
GO:0050008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopiperitenone delta-isomerase activity
REACT:R-SPO-9613494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding of DNA for the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)
REACT:R-DDI-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)
RHEA:55018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => H(+) + menthone + NADPH + O2
RHEA:16057	skos:altLabel	"uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV"
RHEA:16057	skos:altLabel	"beta-acetylglucosaminyltransferase IV"
RHEA:16057	skos:altLabel	"alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase"
RHEA:16057	skos:altLabel	"GnTIV"
RHEA:16057	skos:prefLabel	"alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase"
RHEA:16057	skos:altLabel	"N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV"
RHEA:16057	skos:altLabel	"N-acetylglucosaminyltransferase IV"
RHEA:16057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:16057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase"
RHEA:24994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:60120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine = H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine
RHEA:60120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pre-sodorifen synthase"
RHEA:60120	skos:prefLabel	"pre-sodorifen synthase"
REACT:R-DME-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Drosophila melanogaster)
REACT:R-BTA-1169399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Bos taurus)
RHEA:59613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-L-ornithine + H2O => beta-alanine + L-ornithine
REACT:R-GGA-9038052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GREB1 binds ESR1:ESTG and co-activators (Gallus gallus)
REACT:R-HSA-9679740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA4:ITGB1 binds natalizumab (Homo sapiens)
REACT:R-MMU-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Mus musculus)
REACT:R-BTA-1678944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Bos taurus)
GO:0015650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate:proton symporter activity
GO:0015650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate:proton porter activity
GO:0015650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate:hydrogen symporter activity
GO:0015650	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lactate permease
GO:0015650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate:hydrogen porter activity
REACT:R-CEL-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Caenorhabditis elegans)
REACT:R-CFA-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Canis familiaris)
REACT:R-DRE-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Danio rerio)
REACT:R-MMU-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
RHEA:28825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-galactonate(out) => H(+)(in) + L-galactonate(in)
REACT:R-RNO-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Rattus norvegicus)
REACT:R-HSA-1251997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ERBB4m80 by gamma-scretase complex (Homo sapiens)
REACT:R-BTA-5651773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds POLB at long-patch BER site (Bos taurus)
REACT:R-DME-70524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates PYR to form L-Ala (Drosophila melanogaster)
REACT:R-DME-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Drosophila melanogaster)
REACT:R-MMU-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Mus musculus)
REACT:R-BTA-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Bos taurus)
GO:0102329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA reductase activity
RHEA:58906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH
REACT:R-HSA-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Homo sapiens)
RHEA:30217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H2O + nitrous oxide => a menaquinol + 2 nitric oxide
REACT:R-RNO-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Rattus norvegicus)
REACT:R-BTA-4641134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds AXIN (Bos taurus)
REACT:R-XTR-8943780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 recruits NuRD to PTEN gene (Xenopus tropicalis)
REACT:R-RNO-8952289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAM20C phosphorylates FAM20C substrates (Rattus norvegicus)
RHEA:51211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-leukotriene B4 + NADP(+) <=> 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH
REACT:R-DRE-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Danio rerio)
REACT:R-DRE-177938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Danio rerio)
REACT:R-RNO-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Rattus norvegicus)
REACT:R-HSA-5658163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:48828	skos:prefLabel	"resorcinol 4-hydroxylase (NADPH)"
RHEA:48828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NADP(+)
RHEA:48828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"resorcinol 4-hydroxylase (NADPH)"
RHEA:28368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate
RHEA:34086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA <=> a (3S)-3-hydroxyacyl-CoA
REACT:R-CFA-1297354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acrosin Cleavage (Canis familiaris)
RHEA:28944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(in) => glycine betaine(out)
REACT:R-DRE-8865482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KMT2A (MLL) binds RUNX1 (Danio rerio)
RHEA:72528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine
RHEA:17788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-glutamate <=> 4-aminobutanoate + CO2
REACT:R-CEL-9661405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports BIL from cytosol to extracellular region (blood) (Caenorhabditis elegans)
REACT:R-XTR-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Xenopus tropicalis)
RHEA:15365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP
RHEA:21692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-glycerol diphosphatase"
RHEA:21692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate
RHEA:21692	skos:altLabel	"CDP-glycerol pyrophosphatase"
RHEA:21692	skos:prefLabel	"CDP-glycerol diphosphatase"
REACT:R-DRE-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Danio rerio)
REACT:R-GGA-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Gallus gallus)
REACT:R-SSC-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Sus scrofa)
REACT:R-CFA-1602368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Canis familiaris)
REACT:R-HSA-8850831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates KLK8 (Homo sapiens)
REACT:R-RNO-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Rattus norvegicus)
REACT:R-GGA-198315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IRS recruits PI3K to the plasma membrane and activates it (Gallus gallus)
RHEA:56289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5684250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Bos taurus)
RHEA:64481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate
REACT:R-HSA-9669898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT mutants bind type I TKIs (Homo sapiens)
REACT:R-DRE-6793666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the nucleus (Danio rerio)
REACT:R-DRE-9020255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Danio rerio)
REACT:R-HSA-9014627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDS dimers:PXLP dehydrate L-Thr to 2AA (Homo sapiens)
RHEA:32049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-pentaphosphate + AMP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate
RHEA:48671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Caenorhabditis elegans)
REACT:R-SSC-2396002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Sus scrofa)
RHEA:42081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + H2O + NAD(+) => all-trans-retinoate + 2 H(+) + NADH
RHEA:47400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA
RHEA:30990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> (17Z)-protosta-17(20),24-dien-3beta-ol
GO:0034567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromate reductase activity
RHEA:59215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP <=> AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]
REACT:R-HSA-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Homo sapiens)
RHEA:64283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-phenylethylamine + pyruvate <=> acetophenone + L-alanine
REACT:R-CFA-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Canis familiaris)
RHEA:35760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:18292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate <=> H2O + oxaloacetate
REACT:R-HSA-9662096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of glutamate from cochlear inner hair cell (Homo sapiens)
RHEA:39281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dodecanoate(in) + H(+) + phosphate => ATP + dodecanoate(out) + H2O
REACT:R-DDI-189222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A5 transports fructose from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:63817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine => AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)
RHEA:45726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaraldehyde + H(+) + NADPH => (E)-4-coumaroyl alcohol + NADP(+)
RHEA:39734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-166271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Rattus norvegicus)
RHEA:28880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-tryptophan(in) => H(+)(out) + L-tryptophan(out)
REACT:R-HSA-9694363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerisation of nucleoprotein (Homo sapiens)
RHEA:70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-threonyl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)
REACT:R-HSA-8855954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Homo sapiens)
REACT:R-CFA-5693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYM reduces P2C to PPCA (Canis familiaris)
REACT:R-SCE-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Saccharomyces cerevisiae)
REACT:R-DRE-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Danio rerio)
REACT:R-GGA-5432852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR4:LY96 (Gallus gallus)
REACT:R-PFA-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Plasmodium falciparum)
REACT:R-SSC-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Sus scrofa)
REACT:R-HSA-5213462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds RIPK1 (Homo sapiens)
REACT:R-DME-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Drosophila melanogaster)
REACT:R-DDI-192067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Dictyostelium discoideum)
REACT:R-CEL-2682349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Caenorhabditis elegans)
REACT:R-HSA-9654533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B recycles to the plasma membrane (Homo sapiens)
REACT:R-DDI-9020259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)
GO:0102004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octaprenyl-6-hydroxyphenol methylase activity
GO:0102004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
GO:0102004	skos:altLabel	"2-octaprenyl-6-hydroxyphenol methylase"
GO:0102004	skos:prefLabel	"2-polyprenyl-6-hydroxyphenol methylase"
GO:0102004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-polyprenyl-6-hydroxyphenol methylase"
RHEA:13707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP => alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-RNO-1602484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP11 by FURIN (Rattus norvegicus)
REACT:R-RNO-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Rattus norvegicus)
REACT:R-HSA-9018503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG bind the EBAG9 5' region (Homo sapiens)
RHEA:39781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0102063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-curcumene synthase activity
RHEA:13599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + urea => 1,4-diguanidinobutane + H2O
RHEA:63127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl ethanolamine <=> ethanolamine + octadecanoate
RHEA:47730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose
REACT:R-HSA-5601926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II polymerizes primary piRNA transcript (Homo sapiens)
RHEA:72873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A5 + CoA => anthocyanin A3 + malonyl-CoA
RHEA:25289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5687097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3 binds ETV4 (Canis familiaris)
REACT:R-RNO-5654163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds PLCG1 (Rattus norvegicus)
REACT:R-SSC-193841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Sus scrofa)
RHEA:61941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP
RHEA:15825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AZD1979 + H2O = AZD1979 oxetane hydrolysis product + H(+)
REACT:R-DRE-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Danio rerio)
REACT:R-DRE-8953013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 binds E2F8 (Danio rerio)
RHEA:22000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH
GO:0050135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)(+) nucleosidase activity
GO:0050135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide (phosphate) nucleosidase activity
GO:0050135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)+ glycohydrolase activity
GO:0050135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P) nucleosidase activity
GO:0050135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)ase activity
GO:0050135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity
GO:0050135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)+ nucleosidase activity
GO:0050135	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triphosphopyridine nucleotidase activity
RHEA:57835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxopentanoate + H2O + NADP(+) <=> glutarate + 2 H(+) + NADPH
REACT:R-MMU-8851919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 and GRB2 (Mus musculus)
REACT:R-CFA-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Canis familiaris)
RHEA:24466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-galactonate
RHEA:27496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + tricetin <=> 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine
RHEA:13475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-pyruvate + NADH + NH4(+) => H2O + L-tryptophan + NAD(+)
REACT:R-DRE-211224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with DFF45 (Danio rerio)
RHEA:48703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol
RHEA:15135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+)
RHEA:20590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-GGA-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Gallus gallus)
RHEA:47486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => deoxycholate + NAD(+)
REACT:R-BTA-2424477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
REACT:R-DRE-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Danio rerio)
REACT:R-MMU-9766656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBX1:CUL3 dissociates from forming autophagosome (Mus musculus)
RHEA:44086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + heptadecanoyl-CoA => ATP + CoA + heptadecanoate
REACT:R-DRE-5694494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)
REACT:R-CFA-1592297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full activation of MMP1 (Canis familiaris)
RHEA:52471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-CFA-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
REACT:R-SSC-173680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C5 (Sus scrofa)
RHEA:55697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O => an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate
EC:1.5.3.12	skos:prefLabel	"dihydrobenzophenanthridine oxidase"
EC:1.5.3.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrobenzophenanthridine oxidase"
RHEA:66111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-cysteine <=> (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate
REACT:R-XTR-8987080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Xenopus tropicalis)
REACT:R-HSA-75872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Homo sapiens)
REACT:R-XTR-373700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-9 binds DCC:DIP13alpha complex (Xenopus tropicalis)
RHEA:52257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine
REACT:R-HSA-452515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of STAT3 (Homo sapiens)
REACT:R-CFA-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Canis familiaris)
REACT:R-SCE-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Saccharomyces cerevisiae)
REACT:R-SSC-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Sus scrofa)
RHEA:38768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-BTA-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Bos taurus)
RHEA:10657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosyl-L-methionine => creatine + H(+) + S-adenosyl-L-homocysteine
RHEA:47602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GM4 (d18:1(4E)) + H(+) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate
RHEA:46024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + tetradecanoate = (3R)-hydroxytetradecanoate + H2O
REACT:R-HSA-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Homo sapiens)
REACT:R-RNO-109671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Rattus norvegicus)
RHEA:61873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate
RHEA:13964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mg(2+) + protoporphyrin IX <=> ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate
REACT:R-RNO-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Rattus norvegicus)
REACT:R-DRE-163733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of FAS monomer gene by ChREBP:MLX (Danio rerio)
REACT:R-BTA-419389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA-binding receptors bind LPA (Bos taurus)
RHEA:48126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD3 (d18:1(4E)) + H2O
GO:0000827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Homo sapiens)
GO:0000827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0047731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"catechol oxidase (dimerizing)"
GO:0047731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catechol:oxygen oxidoreductase (dimerizing)
GO:0047731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O
GO:0047731	skos:prefLabel	"catechol oxidase (dimerizing)"
GO:0047731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol oxidase (dimerizing) activity
RHEA:23409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + precorrin-6B => 2 H(+) + NADPH + precorrin-6A
REACT:R-GGA-1369017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in muscle cells (Gallus gallus)
RHEA:25074	skos:altLabel	"hydroperoxide isomerase"
RHEA:25074	skos:prefLabel	"hydroperoxide dehydratase"
RHEA:25074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroperoxide dehydratase"
RHEA:25074	skos:altLabel	"allene oxide synthase"
RHEA:25074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O
RHEA:25074	skos:altLabel	"AOS"
REACT:R-BTA-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Bos taurus)
REACT:R-DDI-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Dictyostelium discoideum)
RHEA:33787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-ketolactose + H2O = 3-keto-beta-D-galactose + beta-D-glucose
REACT:R-DME-5690785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds Ub-HCFC1 (Drosophila melanogaster)
REACT:R-SSC-432956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP230 is recruited to the hemidesmosome (Sus scrofa)
RHEA:47439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z)-hexadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(7Z-hexadecenoyl)-CoA
REACT:R-SSC-2299620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen XI cross-links with collagen II (Sus scrofa)
REACT:R-DRE-381135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Danio rerio)
REACT:R-RNO-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Rattus norvegicus)
RHEA:64458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine
REACT:R-CFA-8848339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA5 hydrolyzes TAG (Canis familiaris)
REACT:R-DME-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Drosophila melanogaster)
REACT:R-HSA-9621270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3 bind PINK1 gene promoter (Homo sapiens)
REACT:R-XTR-210977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Xenopus tropicalis)
RHEA:30194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + plastoquinone-9 <=> 15,9'-di-cis-phytofluene + plastoquinol-9
REACT:R-HSA-400342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ARNTL (BMAL1) (Homo sapiens)
REACT:R-CFA-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Canis familiaris)
REACT:R-MMU-68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Mus musculus)
REACT:R-DRE-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Danio rerio)
REACT:R-CFA-9677585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Canis familiaris)
RHEA:47990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-L-galactonate + NAD(+)
REACT:R-XTR-176101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Rad17-RFC complex to DNA (Xenopus tropicalis)
REACT:R-SCE-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Saccharomyces cerevisiae)
RHEA:43464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-MMU-8876446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ULK1 phosphorylates DENND3 (Mus musculus)
RHEA:68977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH
RHEA:31218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) <=> (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH
RHEA:49116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NADP(+)
REACT:R-DDI-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Dictyostelium discoideum)
REACT:R-MMU-202472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of TRAF6 to CBM complex (Mus musculus)
RHEA:54070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + sesterfisherol => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O
REACT:R-HSA-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Homo sapiens)
RHEA:39951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
RHEA:37934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate
REACT:R-HSA-9604550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEY1 gene expression is stimulated by NOTCH4 (Homo sapiens)
REACT:R-DDI-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:53317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
RHEA:12080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA
RHEA:12080	skos:altLabel	"KASIII"
RHEA:12080	skos:altLabel	"beta-ketoacyl-acyl carrier protein synthase III"
RHEA:12080	skos:altLabel	"3-oxoacyl:ACP synthase III"
RHEA:12080	skos:altLabel	"beta-ketoacyl-ACP synthase III"
RHEA:12080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-ketoacyl-[acyl-carrier-protein] synthase III"
RHEA:12080	skos:altLabel	"3-ketoacyl-acyl carrier protein synthase III"
RHEA:12080	skos:altLabel	"KAS III"
RHEA:12080	skos:prefLabel	"beta-ketoacyl-[acyl-carrier-protein] synthase III"
RHEA:12080	skos:altLabel	"beta-ketoacyl (acyl carrier protein) synthase III"
REACT:R-HSA-158118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Homo sapiens)
RHEA:34725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine + phosphate => 15-methylhexadecasphing-4-enine 1-phosphate + H2O
REACT:R-DME-1604752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by MMP3 (Drosophila melanogaster)
REACT:R-BTA-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Bos taurus)
RHEA:55880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aequorin]--coelenterazine + O2 = [aequorin]
RHEA:53621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => (-)-spiroviolene + diphosphate
GO:0047994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylglutaryl-CoA hydrolase activity
GO:0047994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl-CoA hydrolase activity
GO:0047994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity
GO:0047994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity
GO:0047994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme A hydrolase activity
GO:0047994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity
GO:0047994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme A deacylase activity
REACT:R-MMU-2395412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SYK (Mus musculus)
RHEA:16750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphonoacetate => acetate + H(+) + phosphate
REACT:R-HSA-9029536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of UGT1A3  (Homo sapiens)
RHEA:46229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[peptidyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]
RHEA:67570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate => 3'-phosphoadenylyl sulfate + taurochenodeoxycholate
REACT:R-MMU-428909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-protein  G13 (Mus musculus)
RHEA:46922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + styrene => (E)-cinnamate + H(+)
GO:0051011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microtubule minus-end binding
RHEA:12187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-butane-2,3-diol + NAD(+) <=> (S)-acetoin + H(+) + NADH
GO:1990254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keratin filament binding
REACT:R-RNO-2318623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan binds Hyaluronan and HAPLN1 (Rattus norvegicus)
REACT:R-SPO-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Schizosaccharomyces pombe)
REACT:R-DRE-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Danio rerio)
GO:0015186	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	asparagine/glutamine permease activity
GO:0015186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine transmembrane transporter activity
REACT:R-HSA-8852874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR2 binds C3d, C3dg, iC3b (Homo sapiens)
REACT:R-DRE-157906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin E:Cdk2 complex to the nucleus (Danio rerio)
GO:0103074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-6-phosphate 3-dehydrogenase activity
REACT:R-DRE-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Danio rerio)
RHEA:36493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA
GO:0033422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCC codon-amino acid adaptor activity
GO:0033422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proline tRNA
REACT:R-GGA-1433451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds to p-KIT (Gallus gallus)
RHEA:25479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> alpha-himachalene + diphosphate
RHEA:35631	skos:prefLabel	"cyanidin 3-O-galactosyltransferase"
RHEA:35631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyanidin 3-O-galactosyltransferase"
RHEA:35631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin + UDP-alpha-D-galactose = cyanidin 3-O-beta-D-galactoside + H(+) + UDP
REACT:R-BTA-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
REACT:R-HSA-1011600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rabenosyn-5 connects  Rab5 to VPS-45 (Homo sapiens)
REACT:R-SSC-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)
REACT:R-RNO-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Rattus norvegicus)
RHEA:66399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholate(in) + glutathione(in) + H2O <=> ADP + cholate(out) + glutathione(out) + H(+) + phosphate
GO:0047823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine:D-glutamyl-peptide 5-glutamyltransferase activity
GO:0047823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-gamma-glutamyl transpeptidase activity
GO:0047823	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamyl transpeptidase activity
GO:0047823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamyltransferase activity
REACT:R-RNO-5654605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS3 (Rattus norvegicus)
RHEA:16400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-glucopyranose 1-phosphate <=> D-glucose + D-glucose 1,6-bisphosphate
REACT:R-CFA-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Canis familiaris)
RHEA:38581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-1297275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD9:Izumo Binding (Mus musculus)
RHEA:13438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + UDP-alpha-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP
RHEA:34450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-beta-L-talose + NAD(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH
GO:0034541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylarsinite methyltransferase activity
REACT:R-MMU-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Mus musculus)
REACT:R-CFA-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Canis familiaris)
REACT:R-SPO-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Schizosaccharomyces pombe)
GO:0008426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol-activated phospholipid-dependent PKC inhibitor activity
GO:0008426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC inhibitor activity
GO:0008426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase C inhibitor activity
GO:0008426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity
REACT:R-SSC-73722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of UBF-1:rDNA Promoter (Sus scrofa)
REACT:R-MMU-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Mus musculus)
REACT:R-HSA-5662623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1F binds zinc (Homo sapiens)
RHEA:72275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
RHEA:39001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O
REACT:R-DRE-9640175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Danio rerio)
REACT:R-HSA-8876948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates InlA-bound CDH1 and CTNNB1 (Homo sapiens)
REACT:R-BTA-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Bos taurus)
REACT:R-SSC-202706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha4beta1 binds JAM2:JAM3 (Sus scrofa)
REACT:R-DME-209087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBA is phosphorylated by Phospho IKKB kinase (Drosophila melanogaster)
RHEA:60479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + GTP <=> 3',3',3'-cAAG + 3 diphosphate
REACT:R-XTR-373791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Xenopus tropicalis)
REACT:R-RNO-6807027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 and PTPN2 dephosphorylate MET (Rattus norvegicus)
EC:3.4.22.65	skos:altLabel	"endopeptidase 1 (mite)"
EC:3.4.22.65	skos:altLabel	"major mite fecal allergen Der p 1"
EC:3.4.22.65	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidase 1 (mite)"
EC:3.4.22.65	skos:prefLabel	"peptidase 1 (mite)"
EC:3.4.22.65	skos:altLabel	"allergen Der p 1"
RHEA:47538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
REACT:R-MMU-391941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLT receptors can bind LTB4 (Mus musculus)
REACT:R-RNO-1676149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Rattus norvegicus)
RHEA:34101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + norspermidine => carboxynorspermidine + H(+)
REACT:R-DRE-1889978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALT6 transfers Gal to the tetrasaccharide linker (Danio rerio)
REACT:R-CFA-8950340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Canis familiaris)
REACT:R-BTA-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
RHEA:44636	skos:altLabel	"DNAN demethylase"
RHEA:44636	skos:prefLabel	"2,4-dinitroanisole O-demethylase"
RHEA:44636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitroanisole + H2O = 2,4-dinitrophenol + H(+) + methanol
RHEA:44636	skos:altLabel	"2,4-dinitroanisole ether hydrolase"
RHEA:44636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-dinitroanisole O-demethylase"
GO:1990470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	piRNA cluster binding
REACT:R-SSC-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Sus scrofa)
REACT:R-SSC-9706304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRAP2 (Sus scrofa)
REACT:R-XTR-190429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c (Xenopus tropicalis)
RHEA:44540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-CFA-6799981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 binds bacterial peptidoglycan (Canis familiaris)
REACT:R-XTR-194310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Xenopus tropicalis)
GO:0016641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
REACT:R-SSC-6805620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A and PML bind TP53 (Sus scrofa)
REACT:R-RNO-8848338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes TAG (Rattus norvegicus)
REACT:R-DME-8848247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD4,5 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)
RHEA:67774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end dephospho-ribonucleoside-RNA + phosphate => a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O
GO:0023026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II protein complex binding
REACT:R-HSA-2186607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
REACT:R-CEL-5627275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOPC promotes translocation of CFTR to lysosomes (Caenorhabditis elegans)
REACT:R-DRE-482770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet secretory granule components (Danio rerio)
RHEA:62029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + stigmasteryl 3-beta-D-glucoside => D-glucose + stigmasterol
EC:3.2.3.-	skos:prefLabel	"Hydrolyzing S-glycosyl compounds"
EC:3.2.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hydrolyzing S-glycosyl compounds"
RHEA:45920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-DRE-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Danio rerio)
REACT:R-HSA-5676593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)
REACT:R-SSC-264458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of COP1 (Sus scrofa)
REACT:R-DME-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)
GO:0061594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfofructose kinase activity
GO:0061594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfofructose kinase"
GO:0061594	skos:prefLabel	"sulfofructose kinase"
GO:0061594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + ATP = 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)
REACT:R-GGA-5579023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA2(869-1464) binds KAT6A(1-1118) (Gallus gallus)
REACT:R-CFA-139970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO3:FAD N-oxidises TMA to TMAO (Canis familiaris)
RHEA:13384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + an acyl-CoA <=> a carboxylate + acetyl-CoA
RHEA:67945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoate + O2 => 2-oxohexadecanoate + H2O2
RHEA:58762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH
GO:0005212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of eye lens
REACT:R-HSA-9703439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)
REACT:R-GGA-2424476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV2/3 (Gallus gallus)
REACT:R-HSA-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Homo sapiens)
RHEA:28945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(out) => glycine betaine(in)
GO:0019855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium channel inhibitor activity
RHEA:15922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol
REACT:R-HSA-2294600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates condensin II subunit NCAPD3 (Homo sapiens)
RHEA:44009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-methyl-branched fatty aldehyde + H2O + NAD(+) => a 2-methyl fatty acid + 2 H(+) + NADH
RHEA:65621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinga-(4E,8E)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine
REACT:R-MMU-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Mus musculus)
RHEA:44903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactono-1,4-lactone + H2O <=> D-galactonate + H(+)
RHEA:22854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + L-alanine => L-serine + pyruvate
RHEA:25473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + gamma-himachalene
EC:2.1.1.71	skos:prefLabel	"phosphatidyl-N-methylethanolamine N-methyltransferase"
EC:2.1.1.71	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidyl-N-methylethanolamine N-methyltransferase"
REACT:R-BTA-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Bos taurus)
RHEA:17079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O2 + sarcosine => H2O + N,N-dimethylglycine + O2
REACT:R-DRE-5621615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD209 binds ICAM3 (Danio rerio)
REACT:R-HSA-1247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
RHEA:60110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + H2O => (R)-3-(4-hydroxyphenyl)lactoyl-CoA
RHEA:46216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + progesterone = 3beta-hydroxypregn-4-ene-20-one + NADP(+)
REACT:R-XTR-1454822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP1,2,8,13, PRSS2 (Xenopus tropicalis)
RHEA:24396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scytalone = 1,3,8-trihydroxynaphthalene + H2O
RHEA:24396	skos:prefLabel	"scytalone dehydratase"
RHEA:24396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"scytalone dehydratase"
REACT:R-BTA-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Bos taurus)
RHEA:13415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + dTMP + H(+) => ADP + thymidine
REACT:R-BTA-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Bos taurus)
REACT:R-HSA-2168960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XVII ectodomain shedding (Homo sapiens)
REACT:R-SCE-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Saccharomyces cerevisiae)
REACT:R-CFA-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Canis familiaris)
RHEA:12374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxohex-2-enedioate + H(+) => 2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O
RHEA:54779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)
RHEA:13695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+) => (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium
RHEA:68442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal => beta-cryptoxanthin + O2
REACT:R-RNO-194310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Rattus norvegicus)
REACT:R-CFA-216757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)
GO:0047969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate oxidase activity
GO:0047969	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylate:oxygen oxidoreductase activity
GO:0052725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ins(1,3,4)P(3) 6-kinase activity
GO:0052725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity
GO:0052725	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	inositol-trisphosphate 6-kinase activity
GO:0052725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1,3,4-trisphosphate 6-kinase activity
GO:0052725	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1D-myo-inositol-trisphosphate 6-kinase activity
GO:0052725	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	IP3 6-kinase activity
GO:0052725	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ins(1,3,4)P3 6-kinase activity
GO:0052725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4-trisphosphate 6-kinase activity
RHEA:23585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydropteroate + ATP + L-glutamate => 7,8-dihydrofolate + ADP + H(+) + phosphate
RHEA:57394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-acetyl-4'-O-demethylpapaveroxine + H(+) => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine
RHEA:50449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + prostaglandin G3 => A + H2O + prostaglandin H3
REACT:R-SPO-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)
RHEA:55043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]
GO:0102104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethoxycurcumin synthase activity
REACT:R-RNO-8950757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Rattus norvegicus)
RHEA:18855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxosuccinate + H(+) + NADH => NAD(+) + tartrate
REACT:R-DDI-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Dictyostelium discoideum)
RHEA:17855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-fructose + H2O2 => keto-L-sorbose + O2
REACT:R-HSA-6800200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-HGF to form HGF dimer (Homo sapiens)
REACT:R-DRE-9650473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 is secreted (Danio rerio)
RHEA:34399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone
RHEA:34399	skos:prefLabel	"9-cis-beta-carotene 9',10'-cleaving dioxygenase"
RHEA:34399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"9-cis-beta-carotene 9',10'-cleaving dioxygenase"
GO:0102706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butein:oxygen oxidoreductase activity
REACT:R-HSA-2466834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective OPN1SW causes tritanopia (Homo sapiens)
RHEA:42474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+) => dibenzo-p-dioxin + NADH + O2
REACT:R-GGA-353314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XP-C-RAD23B heterodimer binds to damaged DNA site with lesion (Gallus gallus)
REACT:R-GGA-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Gallus gallus)
REACT:R-MMU-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)
REACT:R-CFA-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)
REACT:R-BTA-163320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of mTERF with the termination sequence (Bos taurus)
REACT:R-BTA-5672958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from KSR1:MARK3 (Bos taurus)
REACT:R-MMU-2172126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAP12 interacts with NKG2C (Mus musculus)
REACT:R-CEL-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Caenorhabditis elegans)
RHEA:15752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-mandelate + A <=> AH2 + phenylglyoxylate
RHEA:60453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate => acetaldehyde + H(+) + sulfite
RHEA:29939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + phosphate(in) = H(+)(out) + phosphate(out)
RHEA:26231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + 3 H(+) + 3 NADPH => 3 NADP(+) + phytyl diphosphate
RHEA:49315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans,4-trans-xanthoxin + NAD(+) <=> 2-trans-(+)-abscisic aldehyde + H(+) + NADH
RHEA:16680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoroacetaldehyde + H2O + NAD(+) <=> fluoroacetate + 2 H(+) + NADH
RHEA:41718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine => a 2-acyl-sn-glycero-3-phospho-L-serine + H2O
REACT:R-SSC-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Sus scrofa)
RHEA:12495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine <=> D-methionine
RHEA:58653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV para-naphthoquinone carboxamide
REACT:R-HSA-9010648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO2 binds AKAP5 (Homo sapiens)
RHEA:15859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + H(+) + NADPH => (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+)
REACT:R-CFA-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Canis familiaris)
REACT:R-CFA-3465545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Canis familiaris)
GO:0034595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyphosphoinositol lipid 5-phosphatase activity
GO:0034595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol phosphate 5-phosphatase activity
GO:0034595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoinositide 5-phosphatase activity
REACT:R-SSC-4086223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IX binds integrin alpha11beta1 (Sus scrofa)
RHEA:56956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITP + pyruvate = H(+) + IDP + phosphoenolpyruvate
RHEA:34136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabigerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2
RHEA:46836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:18110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate
RHEA:66671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose = alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)
RHEA:66952	skos:prefLabel	"dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase"
RHEA:66952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase"
RHEA:67750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate
GO:0080045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3'-O-glucosyltransferase activity
REACT:R-PFA-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Plasmodium falciparum)
REACT:R-CFA-9699578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 phosphorylates CDKN1B (Canis familiaris)
REACT:R-DDI-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Dictyostelium discoideum)
REACT:R-XTR-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Xenopus tropicalis)
REACT:R-BTA-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Bos taurus)
RHEA:10848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type alpha-factor-pheromone transporter"
RHEA:10848	skos:altLabel	"alpha-factor-transporting ATPase"
RHEA:10848	skos:altLabel	"alpha-factor-pheromone transporting ATPase"
RHEA:10848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an [alpha-factor](in) + ATP + H2O = ADP + an [alpha-factor](out) + H(+) + phosphate
RHEA:10848	skos:prefLabel	"ABC-type alpha-factor-pheromone transporter"
GO:0033909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucoidanase activity
GO:0033909	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity
REACT:R-MMU-4085992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DAXX with SUMO1 (Mus musculus)
REACT:R-XTR-9617996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Xenopus tropicalis)
RHEA:42508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-acetamido-2-oxohexanoate + H2O + NAD(+) = 5-acetamidopentanoate + CO2 + H(+) + NADH
RHEA:24681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + formaldehyde <=> 5,10-methylenetetrahydromethanopterin + H2O
RHEA:41401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:62349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide C
REACT:R-DRE-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Danio rerio)
REACT:R-HSA-9759325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds the GSTA3 promoter (Homo sapiens)
REACT:R-CFA-5661120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Canis familiaris)
RHEA:41743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine
REACT:R-DRE-3371518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 binds to HSF1 (Danio rerio)
REACT:R-SSC-109539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Sus scrofa)
REACT:R-HSA-5609939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective PGM1 does not isomerise G6P to G1P (Homo sapiens)
REACT:R-CEL-549129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations into hepatic cells (Caenorhabditis elegans)
REACT:R-SSC-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Sus scrofa)
REACT:R-GGA-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Gallus gallus)
RHEA:36601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + sulfur => hydrogen sulfide + NAD(+)
GO:0015184	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cystine/diaminopimelate porter activity
GO:0015184	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-cystine transporter activity
GO:0015184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine transmembrane transporter activity
GO:0015184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Homo sapiens)
REACT:R-BTA-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Bos taurus)
RHEA:39067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanedioyl-CoA + CoA = acetyl-CoA + hexanedioyl-CoA
RHEA:36236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA
RHEA:44876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,3-diacylglycerol + H2O = 3-acyl-sn-glycerol + a fatty acid + H(+)
RHEA:16068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + phytanoyl-CoA <=> 2-hydroxyphytanoyl-CoA + CO2 + succinate
GO:0035538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ChoRE binding
GO:0035538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate response element binding
RHEA:47238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein] => eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:61914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + voriconazole(out) => ATP + H2O + voriconazole(in)
RHEA:19644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + ATP + CoA <=> (E)-4-coumaroyl-CoA + AMP + diphosphate
RHEA:41612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = D-ribose 2,5-bisphosphate + H(+)
REACT:R-HSA-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Homo sapiens)
REACT:R-BTA-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Bos taurus)
REACT:R-GGA-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Gallus gallus)
REACT:R-CEL-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Caenorhabditis elegans)
RHEA:38700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-DDI-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Dictyostelium discoideum)
REACT:R-SSC-392870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gs activation by prostacyclin receptor (Sus scrofa)
REACT:R-DDI-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
REACT:R-DDI-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Dictyostelium discoideum)
REACT:R-DME-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Drosophila melanogaster)
REACT:R-MMU-2142859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growing HA is extruded from the cell by ABCC5 (Mus musculus)
REACT:R-RNO-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Rattus norvegicus)
RHEA:68408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-iso(homo)3citrate + NAD(+) = 2-oxosuberate + CO2 + NADH
REACT:R-XTR-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)
REACT:R-RNO-1592398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP8 (Rattus norvegicus)
REACT:R-DME-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Drosophila melanogaster)
REACT:R-RNO-5692283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Rattus norvegicus)
REACT:R-MMU-5694082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XK:KEL:Zn2+ cleaves EDN3 (Mus musculus)
REACT:R-CFA-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Canis familiaris)
GO:0097020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII receptor activity
REACT:R-XTR-5654510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 binds SPRED1/2 (Xenopus tropicalis)
REACT:R-HSA-3371359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Homo sapiens)
REACT:R-DRE-8853514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Danio rerio)
RHEA:31431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-santalene synthase"
RHEA:31431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-beta-santalene + diphosphate
RHEA:31431	skos:prefLabel	"beta-santalene synthase"
REACT:R-BTA-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Bos taurus)
RHEA:28877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-tyrosine(out) => H(+)(in) + L-tyrosine(in)
REACT:R-DDI-6799466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 dimerizes (Dictyostelium discoideum)
REACT:R-HSA-5334152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)
RHEA:41888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)
REACT:R-SSC-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Sus scrofa)
RHEA:29235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H(+) + NADH = a menaquinol + NAD(+)
REACT:R-DRE-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Danio rerio)
REACT:R-BTA-2162227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses (HA)2 (Bos taurus)
RHEA:18637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + NADP(+) = H(+) + NADPH
REACT:R-CFA-210277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-1 (Canis familiaris)
REACT:R-SSC-8951499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides on to class I MHC (Sus scrofa)
RHEA:22007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-seryl-[myosin light chain]
REACT:R-DME-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Drosophila melanogaster)
REACT:R-CFA-6786650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDHD1,2 hydrolyse PA (Canis familiaris)
REACT:R-DRE-5649802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Danio rerio)
REACT:R-SPO-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Schizosaccharomyces pombe)
RHEA:56236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine
RHEA:33779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-kestotriose + sucrose = 6,6-kestotetraose + beta-D-glucose
RHEA:17043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + H2O
REACT:R-SSC-5362500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Sus scrofa)
RHEA:64622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl actetate + CoA => (E)-sinapyl alcohol + acetyl-CoA
REACT:R-GGA-6784189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind LIFR (Gallus gallus)
REACT:R-CEL-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Caenorhabditis elegans)
RHEA:60869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP
REACT:R-RNO-193682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves the p75NTR transmembrane domain (Rattus norvegicus)
REACT:R-RNO-111751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)
RHEA:34742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine <=> H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine
REACT:R-DDI-5687360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLL or POLM extends aligned DNA DSB ends to fill gaps (Dictyostelium discoideum)
REACT:R-DDI-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)
REACT:R-DME-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Drosophila melanogaster)
RHEA:44944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-3-acyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + a fatty acid + H(+)
RHEA:49391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + validoxylamine A <=> H(+) + UDP + validamycin A
REACT:R-DDI-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Dictyostelium discoideum)
RHEA:31998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> 7-epi-sesquithujene + diphosphate
RHEA:41185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
REACT:R-GGA-8862771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G2A binds bacterial phospholipids (Gallus gallus)
RHEA:33063	skos:altLabel	"putidaredoxin reductase"
RHEA:33063	skos:prefLabel	"putidaredoxin--NAD(+) reductase"
RHEA:33063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"putidaredoxin--NAD(+) reductase"
RHEA:33063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] = NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]
RHEA:33507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine
GO:0034911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phthalate 3,4-dioxygenase activity
RHEA:16502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-1D-myo-inositol => H(+) + myo-inositol + sn-glycerol 3-phosphate
GO:0061809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ nucleotidase, cyclic ADP-ribose generating
GO:0048185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activin binding
REACT:R-CFA-1602488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by plasmin and trypsin (Canis familiaris)
RHEA:24312	skos:altLabel	"cytochrome c methyltransferase"
RHEA:24312	skos:altLabel	"cytochrome c-specific protein methylase III"
RHEA:24312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[cytochrome c]-lysine N-methyltransferase"
RHEA:24312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine
RHEA:24312	skos:altLabel	"cytochrome c-specific protein-lysine methyltransferase"
RHEA:24312	skos:prefLabel	"[cytochrome c]-lysine N-methyltransferase"
RHEA:24312	skos:altLabel	"cytochrome c (lysine) methyltransferase"
RHEA:67572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-muricholate = adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)
RHEA:20714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + CO2 + CoA => 6-carboxyhexanoyl-CoA + H(+) + L-alanine
RHEA:17042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + H2O => AMP + 2 H(+) + sulfate
RHEA:48957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O
REACT:R-PFA-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Plasmodium falciparum)
EC:2.8.3.-	skos:prefLabel	"CoA-transferases"
EC:2.8.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CoA-transferases"
RHEA:68348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP = diphosphate + pppA(2'-5')pG
REACT:R-RNO-196026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dab2 is recruited to the junctional plaques (Rattus norvegicus)
RHEA:25481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + succinyl-CoA => acetoacetyl-CoA + succinate
REACT:R-SSC-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Sus scrofa)
RHEA:54156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate
RHEA:25731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-tetrahomomethionine = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O
RHEA:14288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP
REACT:R-DRE-6784006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Danio rerio)
RHEA:33562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphate <=> a 2-acyl-sn-glycerol 3-phosphate + CoA
REACT:R-CFA-1482543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Canis familiaris)
REACT:R-DDI-9033527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)
REACT:R-HSA-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Homo sapiens)
REACT:R-BTA-9027627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Bos taurus)
GO:0047836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophan N-malonyltransferase activity
GO:0047836	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:D-tryptophan N-malonyltransferase activity
REACT:R-CFA-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Canis familiaris)
REACT:R-XTR-2428930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Xenopus tropicalis)
RHEA:22807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S,9R)-vomifoliol + NAD(+) <=> (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH
REACT:R-SSC-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Sus scrofa)
REACT:R-BTA-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Bos taurus)
REACT:R-HSA-2106586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)
GO:0009978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]
GO:0009978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allene oxide synthase activity
GO:0009978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroperoxide dehydratase activity
GO:0009978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HPI
GO:0009978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate hydroperoxide isomerase
GO:0009978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroperoxide isomerase activity
GO:0009978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity
GO:0009978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleic acid hydroperoxide isomerase
RHEA:14630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-L-glutamate => ADP + N-acetyl-L-glutamyl 5-phosphate
EC:3.4.14.10	skos:altLabel	"tripeptidyl aminopeptidase"
EC:3.4.14.10	skos:prefLabel	"tripeptidyl-peptidase II"
EC:3.4.14.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tripeptidyl-peptidase II"
EC:3.4.14.10	skos:altLabel	"tripeptidyl peptidase"
REACT:R-HSA-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
RHEA:27402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxychromene-2-carboxylate => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate
REACT:R-CFA-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)
RHEA:57194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + H(+) + L-lysyl-[protein] => H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]
REACT:R-HSA-111238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR2  homodimer (Homo sapiens)
REACT:R-GGA-5660662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASC binds Caspase-8 complex (Gallus gallus)
REACT:R-MMU-427645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A3 cotransports Pi, 2Na+ (Mus musculus)
RHEA:52243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 Mn(2+) + O2 <=> 4 H(+) + 2 MnO2
RHEA:43058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+) => 5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH
REACT:R-CFA-5684806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates CLEC1B dimer:PDPN (Canis familiaris)
RHEA:71956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + 3 Na(+)(out) => glutarate(in) + 3 Na(+)(in)
REACT:R-HSA-9664261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)
REACT:R-MMU-77593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage and polyadenylation of Intronless Pre-mRNA (Mus musculus)
RHEA:61981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + ubiquinone-10 => NADP(+) + ubiquinol-10
REACT:R-MMU-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Mus musculus)
GO:0080131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	12-OHJA sulfotransferase activity
GO:0080131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	11-OHJA sulfotransferase activity
GO:0080131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	12-hydroxyjasmonic acid sulfotransferase activity
GO:0080131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyjasmonic acid sulfotransferase activity
GO:0080131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	12-hydroxyjasmonate sulfotransferase activity
GO:0080131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyjasmonate sulfotransferase activity
GO:0080131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	11-hydroxyjasmonate sulfotransferase activity
GO:0080131	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	11-hydroxyjasmonic acid sulfotransferase activity
GO:0080131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OHJA sulfotransferase activity
RHEA:50036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine
REACT:R-GGA-5624953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL13B binds INPP5E (Gallus gallus)
REACT:R-SSC-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Sus scrofa)
RHEA:44300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA = 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA
GO:0035259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear glucocorticoid receptor binding
GO:0035259	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glucocorticoid receptor binding
GO:0047672	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	benzoyl-CoA:anthranilate N-benzoyltransferase
GO:0047672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate N-benzoyltransferase activity
REACT:R-BTA-3215310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)
REACT:R-BTA-196086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Bos taurus)
REACT:R-DDI-9020262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Dictyostelium discoideum)
RHEA:51752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4-prenylphloroglucinol + diphosphate
REACT:R-SSC-3788075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by ADAMTS4, ADAMTS5 (Sus scrofa)
RHEA:28099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GDP => AMP + guanosine 3',5'-bis(diphosphate)
RHEA:46749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyphosphate + NH4(+) => carbamate + 2 H(+) + phosphate
REACT:R-DRE-191636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cx43 by c-src (Danio rerio)
RHEA:13680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> D-xylulose 5-phosphate
REACT:R-DRE-8952419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs ubiquitinate RUNX3 (Danio rerio)
GO:0018452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-exo-hydroxycamphor dehydrogenase activity
GO:0034043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxymethyluracil DNA N-glycosylase activity
GO:0034043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hmU DNA N-glycosylase activity
REACT:R-RNO-2066788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Rattus norvegicus)
REACT:R-DRE-158832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT2 (Danio rerio)
RHEA:35062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloramphenicol(in) + H(+)(out) <=> chloramphenicol(out) + H(+)(in)
RHEA:40998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA <=> 4-hydroxybenzaldehyde + acetyl-CoA
REACT:R-CFA-2022383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)
REACT:R-HSA-9009401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SMURF1 (Homo sapiens)
RHEA:39487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA = (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O
RHEA:37930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
RHEA:31163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O
RHEA:21800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin + L-ascorbate = all-trans-zeaxanthin + H2O + L-dehydroascorbate
REACT:R-XTR-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Xenopus tropicalis)
RHEA:65902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H2O + xanthurenate => 3-hydroxy-L-kynurenine + glyoxylate
REACT:R-HSA-8948582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-17 microRNA binds VAPA mRNA (Homo sapiens)
REACT:R-SSC-2730664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Sus scrofa)
RHEA:41318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
GO:0050656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPS binding
GO:0050656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoadenosine phosphosulfate binding
GO:0050656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3'-phosphate 5'-phosphosulfate binding
GO:0050656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenosine 5'-phosphosulphate binding
GO:0050656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl-sulfate binding
GO:0050656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenosine 5'-phosphosulfate binding
GO:0004915	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gp130
GO:0004915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-6 receptor activity
GO:0004915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-6 receptor activity
GO:0004915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-6R
RHEA:35138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-L-glutamate(out) <=> L-alanyl-L-glutamate(in)
GO:0044103	skos:prefLabel	"L-arabinose 1-dehydrogenase [NAD(P)(+)]"
GO:0044103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-arabinose 1-dehydrogenase [NAD(P)(+)]"
GO:0044103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinose 1-dehydrogenase (NADP+) activity
REACT:R-RNO-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)
REACT:R-CEL-164832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase synthesizes ATP (Caenorhabditis elegans)
REACT:R-XTR-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)
RHEA:51066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate => 3'-phosphoadenylyl sulfate + lithocholate
REACT:R-XTR-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Xenopus tropicalis)
GO:0140932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	m(7)GpppX pyrophosphatase activity
GO:0140932	skos:prefLabel	"5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase"
GO:0140932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
GO:0140932	skos:altLabel	"m(7)GpppN m(7)GMP phosphohydrolase"
GO:0140932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP
GO:0140932	skos:altLabel	"m(7)GpppX diphosphatase"
GO:0140932	skos:altLabel	"m(7)GpppX pyrophosphatase"
GO:0140932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase"
GO:0140932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	m(7)GpppN m(7)GMP phosphohydrolase activity
GO:0140932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	m(7)GpppX diphosphatase activity
GO:0140932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)
RHEA:40038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + N-acetyl-L-aspartate <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate
REACT:R-MMU-1973956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 binds ERBB4jmAcyt1s80 dimer (Mus musculus)
REACT:R-DRE-173631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1s (Danio rerio)
RHEA:38593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroorienticin B + dTDP + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine
REACT:R-HSA-5423637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR dimers reduce AFBDHO to AFBDOH (Homo sapiens)
REACT:R-XTR-168405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD oligomer recruites RIP2 (RICK) (Xenopus tropicalis)
RHEA:46615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol <=> (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
REACT:R-HSA-1980138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 binds DLL/JAG ligand in cis (Homo sapiens)
REACT:R-MMU-390641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA1A,B,D bind ADR,NAd (Mus musculus)
REACT:R-CEL-1234167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of HIF:CBP:p300 complex at promoters (Caenorhabditis elegans)
REACT:R-GGA-418576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 1:Gq complex (Gallus gallus)
EC:6.4.1.-	skos:prefLabel	"Forming carbon-carbon bonds"
EC:6.4.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming carbon-carbon bonds"
GO:0102526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethylnovobiocic acid C8-methyltransferase activity
RHEA:51105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0016817	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement
GO:0016817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid anhydrides
GO:0016817	skos:prefLabel	"Acting on acid anhydrides"
GO:0016817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on acid anhydrides"
RHEA:61753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolbioside + UDP-alpha-D-glucose => H(+) + rebaudioside B + UDP
REACT:R-GGA-352107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Gallus gallus)
RHEA:18124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteine + H2O <=> a thiol + NH4(+) + pyruvate
RHEA:10664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde
RHEA:10664	skos:prefLabel	"perillyl-alcohol dehydrogenase"
RHEA:10664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"perillyl-alcohol dehydrogenase"
RHEA:67264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine = (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine
REACT:R-SSC-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Sus scrofa)
REACT:R-RNO-75090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR1 homodimer to dsRNA duplex (Rattus norvegicus)
REACT:R-GGA-8964246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in G alpha (12)-BTK complex is activated (Gallus gallus)
REACT:R-CEL-1605624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase hydrolyses GM1 to GM2 (Caenorhabditis elegans)
REACT:R-XTR-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)
RHEA:62800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 7-demethylsiderin + NADPH + O2 = 2 H2O + NADP(+) + orlandin
REACT:R-SSC-445752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Sus scrofa)
RHEA:23427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucosamine 1-phosphate <=> D-glucosamine 6-phosphate
REACT:R-DRE-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Danio rerio)
REACT:R-GGA-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Gallus gallus)
REACT:R-XTR-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Xenopus tropicalis)
RHEA:34341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => (22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:59240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + L-lysine = L-homoarginine + L-ornithine
RHEA:11787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate + NADP(+) <=> H(+) + NADPH + NH4(+) + oxaloacetate
REACT:R-PFA-351987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A6-mediated uptake of taurine and beta-alanine (Plasmodium falciparum)
RHEA:35424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP
GO:0005030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotrophin receptor activity
RHEA:62116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + iminosuccinate = NH4(+) + oxaloacetate
REACT:R-GGA-2132278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C5 by C5 convertases (Gallus gallus)
REACT:R-MMU-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Mus musculus)
REACT:R-HSA-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Homo sapiens)
REACT:R-HSA-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Homo sapiens)
REACT:R-BTA-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Bos taurus)
REACT:R-BTA-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Bos taurus)
RHEA:15273	skos:prefLabel	"dihydroxyphenylalanine transaminase"
RHEA:15273	skos:altLabel	"DOPA aminotransferase"
RHEA:15273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-dopa = 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate
RHEA:15273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroxyphenylalanine transaminase"
RHEA:15273	skos:altLabel	"dihydroxyphenylalanine aminotransferase"
RHEA:52725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate => a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)
RHEA:55806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+) => (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O
REACT:R-SSC-8874204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3 (Sus scrofa)
GO:0047573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutyrate deacetylase activity
GO:0047573	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-acetamidobutanoate amidohydrolase activity
RHEA:23997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+)
REACT:R-MMU-198983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NKG2D homodimer interacting with ligands (Mus musculus)
RHEA:42389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl crocetin + H(+) + UDP
REACT:R-SPO-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Schizosaccharomyces pombe)
REACT:R-RNO-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Rattus norvegicus)
REACT:R-HSA-8938251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP (Homo sapiens)
REACT:R-BTA-198266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
REACT:R-BTA-77277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Bos taurus)
RHEA:59154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + pseudomonoyl-CoA C => ATP + CoA + pseudomonate C
RHEA:45657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-HSA-5228940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcytosis and dissociation of botB:NTNHA:HA (Homo sapiens)
REACT:R-SSC-1227670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p130 (RBL2) (Sus scrofa)
RHEA:72288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dimethylsuccinate(out) + 3 Na(+)(out) => 2,2-dimethylsuccinate(in) + 3 Na(+)(in)
REACT:R-BTA-74220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Bos taurus)
REACT:R-RNO-5672843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1S1 (PRAS40) binds mTORC1 (Rattus norvegicus)
REACT:R-DRE-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Danio rerio)
RHEA:10400	skos:altLabel	"glutaminase II"
RHEA:10400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamine--pyruvate transaminase"
RHEA:10400	skos:altLabel	"glutamine--pyruvate aminotransferase"
RHEA:10400	skos:altLabel	"glutamine transaminase L"
RHEA:10400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine
RHEA:10400	skos:altLabel	"glutamine--oxo-acid transaminase"
RHEA:10400	skos:prefLabel	"glutamine--pyruvate transaminase"
RHEA:17316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidine + tRNA(His) <=> AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
REACT:R-SCE-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Saccharomyces cerevisiae)
RHEA:45534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-DRE-111956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin activates Cam-PDE 1 (Danio rerio)
RHEA:15734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2
REACT:R-CEL-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)
RHEA:23814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-menthone + H(+) + NADPH => (+)-neomenthol + NADP(+)
REACT:R-SSC-166245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Sus scrofa)
RHEA:17779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
RHEA:65640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine
REACT:R-XTR-209532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR C-terminal fragment enters endosomes (Xenopus tropicalis)
REACT:R-HSA-8865454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX3 (Homo sapiens)
RHEA:68225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + O2 + prekainate => CO2 + H2O + kainate lactone + succinate
REACT:R-MMU-76500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBXAS1 isomerises PGH2 to TXA2 (Mus musculus)
REACT:R-RNO-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Rattus norvegicus)
REACT:R-MMU-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Mus musculus)
GO:0097269	skos:altLabel	"decaprenyl-diphosphate synthase"
GO:0097269	skos:altLabel	"terpenoidallyltransferase"
GO:0097269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans,6-trans-farnesyl diphosphate activity
GO:0097269	skos:prefLabel	"all-trans-decaprenyl-diphosphate synthase"
GO:0097269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate
GO:0097269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity
GO:0097269	skos:altLabel	"polyprenylpyrophosphate synthetase"
GO:0097269	skos:altLabel	"decaprenyl pyrophosphate synthetase"
GO:0097269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-decaprenyl-diphosphate synthase"
GO:0097269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-decaprenyl-diphosphate synthase activity
GO:0097269	skos:altLabel	"terpenyl pyrophosphate synthetase"
GO:0097269	skos:altLabel	"trans-prenyltransferase"
REACT:R-RNO-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Rattus norvegicus)
REACT:R-DRE-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Danio rerio)
REACT:R-DRE-6782211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the TC-NER site (Danio rerio)
GO:0072349	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	modified amino acid transporter activity
GO:0072349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid derivative transmembrane transporter activity
GO:0072349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	modified amino acid transmembrane transporter activity
RHEA:63617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin + UDP-alpha-D-glucuronate => H(+) + prunetin-C(8)-beta-D-glucuronide + UDP
RHEA:56927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]
REACT:R-RNO-975593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Rattus norvegicus)
REACT:R-XTR-392751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 linked to actin cytoskeleton by ankyrin (Xenopus tropicalis)
RHEA:15871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate + pyruvate => 2-oxoglutarate + D-alanine
REACT:R-XTR-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Xenopus tropicalis)
REACT:R-XTR-6806957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET receptor dimerizes (Xenopus tropicalis)
RHEA:49733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O2 + violaceinate => CO2 + H2O + violacein
REACT:R-SSC-5610723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind SUFU (Sus scrofa)
RHEA:48715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(2+) + 2 H(+) + H2O2 <=> 2 Fe(3+) + 2 H2O
REACT:R-DRE-6804402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F1 (Danio rerio)
REACT:R-CEL-5607734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta translocates to plasma membrane (Caenorhabditis elegans)
REACT:R-XTR-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Xenopus tropicalis)
RHEA:18726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => acetyl-CoA + vanillin
REACT:R-HSA-195726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  NA into rafts (Homo sapiens)
REACT:R-GGA-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Gallus gallus)
REACT:R-SSC-9620515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2B,EP300 acetylate FOXO3 under oxidative stress (Sus scrofa)
REACT:R-HSA-879358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGER-1,2,3 bind AGEs (Homo sapiens)
EC:2.4.1.375	skos:prefLabel	"rhamnogalacturonan I galactosyltransferase"
EC:2.4.1.375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnogalacturonan I galactosyltransferase"
RHEA:25735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-2467809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESPL1 (Separase) cleaves centromeric cohesin (Bos taurus)
REACT:R-MMU-429786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Mus musculus)
RHEA:65597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:52290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:10217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DNA-directed RNA polymerase] + ATP => ADP + H(+) + phospho-[DNA-directed RNA polymerase]
RHEA:31640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycinamicin III + S-adenosyl-L-methionine => H(+) + mycinamicin IV + S-adenosyl-L-homocysteine
RHEA:59684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaose + O2 = D-maltohexaono-1,5-lactone + H2O2
RHEA:66815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH <=> 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B
REACT:R-DME-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Drosophila melanogaster)
RHEA:69794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-phenylalanyl-tRNA(Phe) + H2O <=> D-phenylalanine + H(+) + tRNA(Phe)
REACT:R-HSA-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Homo sapiens)
REACT:R-HSA-176250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR-ATRIP to the RPA-ssDNA complex (Homo sapiens)
RHEA:67344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 7-O-beta-D-glucoside + malonyl-CoA = CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)
EC:3.4.24.34	skos:prefLabel	"neutrophil collagenase"
EC:3.4.24.34	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neutrophil collagenase"
EC:3.4.24.34	skos:altLabel	"matrix metalloproteinase 8"
REACT:R-BTA-451347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JNK by DSCAM (Bos taurus)
RHEA:33743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
GO:0015658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucine/valine/isoleucine permease activity
GO:0015658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain amino acid transmembrane transporter activity
GO:0015658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain aliphatic amino acid transmembrane transporter activity
GO:0015658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix (Homo sapiens)
GO:0015658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain aliphatic amino acid transporter activity
GO:0015658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine/tyrosine/tryptophan permease activity
RHEA:14078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + L-alanine => beta-alanine + pyruvate
GO:0032554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine deoxyribonucleotide binding
REACT:R-DRE-397891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:G12/13 (active) dissociate (Danio rerio)
RHEA:51373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-hexadecenoyl)-glycine
REACT:R-SCE-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Saccharomyces cerevisiae)
REACT:R-DME-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Drosophila melanogaster)
REACT:R-XTR-6808496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)
RHEA:38714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol
EC:3.1.26.n2	skos:altLabel	"argonaute RISC catalytic component 2"
EC:3.1.26.n2	skos:prefLabel	"argonaute-2"
EC:3.1.26.n2	skos:altLabel	"eukaryotic translation initiation factor 2C 2"
EC:3.1.26.n2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"argonaute-2"
REACT:R-BTA-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Bos taurus)
REACT:R-RNO-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)
REACT:R-SSC-193766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
RHEA:65939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose <=> beta-D-glucose
REACT:R-XTR-9026405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Xenopus tropicalis)
REACT:R-CFA-140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor V -> factor Va + factor V activation peptide (Canis familiaris)
RHEA:50094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-fatty acyl-taurine + CoA + H(+) => a fatty acyl-CoA + taurine
REACT:R-DME-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Drosophila melanogaster)
REACT:R-MMU-2484822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore assembly (Mus musculus)
GO:0030297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor protein tyrosine kinase activator activity
REACT:R-BTA-5218822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK binds BCAR1 and or PXN (Bos taurus)
REACT:R-HSA-5694427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA3 binds procollagen VII (Homo sapiens)
REACT:R-PFA-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Plasmodium falciparum)
REACT:R-DRE-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Danio rerio)
REACT:R-MMU-8866941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MID1IP1 binds THRSP (Mus musculus)
RHEA:29728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethane-1-sulfonate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + sulfite
REACT:R-DRE-6798489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A7 or S100A7A binds Zn2+ (Danio rerio)
EC:3.4.22.41	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin F"
EC:3.4.22.41	skos:prefLabel	"cathepsin F"
REACT:R-BTA-174174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Bos taurus)
REACT:R-BTA-432295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPVI binds Fyn and Lyn (Bos taurus)
REACT:R-DDI-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Dictyostelium discoideum)
REACT:R-RNO-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Rattus norvegicus)
EC:2.7.11.3	skos:prefLabel	"dephospho-[reductase kinase] kinase"
EC:2.7.11.3	skos:altLabel	"AMP-activated protein kinase kinase"
EC:2.7.11.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dephospho-[reductase kinase] kinase"
EC:2.7.11.3	skos:altLabel	"AMP-activated kinase"
EC:2.7.11.3	skos:altLabel	"reductase kinase kinase"
EC:2.7.11.3	skos:altLabel	"hydroxymethylglutaryl coenzyme A reductase kinase kinase"
EC:2.7.11.3	skos:altLabel	"reductase kinase"
RHEA:61894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH
RHEA:43926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + pregn-5-ene-3,20-dione => NAD(+) + pregnenolone
REACT:R-XTR-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Xenopus tropicalis)
RHEA:62641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycoredoxin]-L-dithiol + a hydroperoxide => [mycoredoxin]-L-disulfide + an alcohol + H2O
RHEA:48982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2,3-dichloromuconate + 2 H(+) => 3,4-dichlorocatechol + O2
REACT:R-DDI-165162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TSC2 by PKB (Dictyostelium discoideum)
RHEA:70704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cycloserine(in) + H(+)(in) => D-cycloserine(out) + H(+)(out)
GO:0008327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-CpG binding
RHEA:48005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O
REACT:R-HSA-9018573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds activated EGFR (Homo sapiens)
REACT:R-DRE-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Danio rerio)
REACT:R-XTR-8940561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP7 cleaves OPTC (Xenopus tropicalis)
RHEA:40114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H2O <=> butanoate + CoA + H(+)
GO:0140955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36 trimethyltransferase activity
GO:0140955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K36 trimethylation
GO:0140955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-trimethyltransferase activity (H3-K36 specific)
GO:0140955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36 trimethylase activity
GO:0140955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36 mono/di/trimethylase activity
GO:0140955	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K36 trimethylation
REACT:R-SSC-2029460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates LIMK1 (Sus scrofa)
RHEA:69258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => H2O + progoitrin
RHEA:66282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP => solanidine + UDP-alpha-D-glucose
RHEA:51645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADH + O2 => 7-dehydrocholesterol + 2 H2O + NAD(+)
REACT:R-CFA-265645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Influx through Voltage-gated Calcium Channels (Canis familiaris)
RHEA:57076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase"
RHEA:57076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate 4-phosphate + H2O = (2R)-3-phosphoglycerate + glycolate + H(+)
RHEA:57076	skos:prefLabel	"3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase"
RHEA:14563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-[(E,E)-piperoyl]piperidine => (E,E)-piperoyl-CoA + piperidine
RHEA:52314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-dehydro-thromboxane B2 + H(+) + NADH => NAD(+) + thromboxane B2
REACT:R-HSA-2012074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3c P250R mutant binds to ligand with enhanced affinity (Homo sapiens)
RHEA:12421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-tagatofuranose 6-phosphate => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)
REACT:R-CFA-199206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Canis familiaris)
REACT:R-CEL-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Caenorhabditis elegans)
REACT:R-SCE-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Saccharomyces cerevisiae)
REACT:R-DRE-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Danio rerio)
REACT:R-HSA-5688899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CSF2RA does not bind SFTPs (Homo sapiens)
REACT:R-DRE-2299620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen XI cross-links with collagen II (Danio rerio)
RHEA:23214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + beta-alanine => H2O + N-acetyl-beta-alanine
RHEA:40244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH
GO:0016297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein hydrolase activity
GO:0016297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-[acyl-carrier-protein] hydrolase activity
GO:0016297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-ACP thioesterase activity
GO:0016297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl carrier protein hydrolase activity
GO:0016297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-[acyl-carrier protein] hydrolase activity
GO:0016297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-ACP hydrolase activity
GO:0016297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-ACP-hydrolase activity
GO:0016297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-acyl fatty acid synthase thioesterase activity
REACT:R-MMU-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Mus musculus)
RHEA:42330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O
REACT:R-RNO-5223313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Rattus norvegicus)
GO:0061629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II repressing transcription factor binding
GO:0061629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II sequence-specific DNA binding transcription factor binding
GO:0061629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcription factor binding
GO:0061629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II activating transcription factor binding
GO:0061629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II sequence-specific DNA-binding transcription factor binding
GO:0061629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II-specific DNA-binding transcription factor binding
REACT:R-XTR-2730840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Xenopus tropicalis)
REACT:R-MMU-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Mus musculus)
REACT:R-RNO-5676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD74 binds MIF (Rattus norvegicus)
REACT:R-XTR-2993447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6x(PCCA:PCCB) (Xenopus tropicalis)
REACT:R-DRE-2213201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibres (Danio rerio)
REACT:R-DME-8865320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX1 (Drosophila melanogaster)
REACT:R-CEL-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Caenorhabditis elegans)
REACT:R-DDI-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Dictyostelium discoideum)
REACT:R-RNO-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)
RHEA:11880	skos:altLabel	"6-hydroxy-L-nicotine oxidase"
RHEA:11880	skos:prefLabel	"(S)-6-hydroxynicotine oxidase"
RHEA:11880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-6-hydroxynicotine oxidase"
RHEA:11880	skos:altLabel	"L-6-hydroxynicotine oxidase"
RHEA:11880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2
GO:0102333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stearoyl-[acp] elongase/decarboxylase activity
REACT:R-BTA-990489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-13 is a dimer (Bos taurus)
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	15-hydroxyprostaglandin dehydrogenase (NADP)
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP-specific 15-hydroxyprostaglandin dehydrogenase
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-PGD2 dehydrogenase activity
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	15-hydroxy PGD2 dehydrogenase activity
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin D2 dehydrogenase activity
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-D 15-dehydrogenase (NADP+) activity
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, prostaglandin D2
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-linked prostaglandin D2 dehydrogenase activity
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP-dependent 15-hydroxyprostaglandin dehydrogenase
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP-linked 15-hydroxyprostaglandin dehydrogenase
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-D 15-dehydrogenase (NADP(+)) activity
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-D 15-dehydrogenase (NADP)
GO:0047020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)
REACT:R-BTA-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Bos taurus)
REACT:R-GGA-3322434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP dissociates from ub-TLE (Gallus gallus)
RHEA:72440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + ATP + H(+) => (E)-feruloyl-AMP + diphosphate
RHEA:33999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zymosterol = 5alpha-cholesta-7,24-dien-3beta-ol
REACT:R-XTR-1604368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of bound proMMP2 (Xenopus tropicalis)
REACT:R-GGA-163843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-GAS6 to GAS6 (Gallus gallus)
RHEA:11625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(hydroxyimino)propanoate + acetone => acetone oxime + pyruvate
REACT:R-XTR-9700168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates IRS1 (Xenopus tropicalis)
REACT:R-DRE-5607757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TRAF6 ubiquitinates TAK1 (Danio rerio)
RHEA:14623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol => (S)-2,3-epoxysqualene
RHEA:15120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + ATP <=> 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine
GO:0140757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type deNEDDylase activity
REACT:R-DDI-3247836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer recycles WLS to the Golgi (Dictyostelium discoideum)
REACT:R-RNO-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Rattus norvegicus)
REACT:R-HSA-8961946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds the CDT1 gene promoter (Homo sapiens)
RHEA:45141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O => CO2 + L-glutamyl-[protein] + O2 + phylloquinol
RHEA:50441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H1 => prostaglandin D1
REACT:R-MMU-437139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT6 transports zinc into the golgi apparatus (Mus musculus)
RHEA:67871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] <=> 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)
RHEA:62307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine <=> (+)-premalbrancheamide
REACT:R-BTA-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Bos taurus)
GO:0097007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity
GO:0097007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMTT synthase activity
GO:0097007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity
RHEA:53427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + a sphingoid base <=> an N-acyl-sphingoid base + CoA + H(+)
RHEA:61932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-miconazole(in) + ATP + H2O = (S)-miconazole(out) + ADP + H(+) + phosphate
REACT:R-MMU-9025969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Mus musculus)
GO:0102823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol-3-rhamnoside-glucosyltransferase activity
REACT:R-GGA-994137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Gallus gallus)
EC:3.5.1.46	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-aminohexanoate-oligomer exohydrolase"
EC:3.5.1.46	skos:altLabel	"6-aminohexanoate-dimer hydrolase"
EC:3.5.1.46	skos:altLabel	"6-aminohexanoic acid oligomer hydrolase"
EC:3.5.1.46	skos:prefLabel	"6-aminohexanoate-oligomer exohydrolase"
EC:3.5.1.46	skos:altLabel	"nylon-6 hydrolase"
GO:0047825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lactate-2-sulphatase activity
GO:0047825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-O-sulfolactate 2-sulfohydrolase activity
GO:0047825	skos:prefLabel	"D-lactate-2-sulfatase"
GO:0047825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-lactate-2-sulfatase"
GO:0047825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lactate-2-sulfatase activity
GO:0047825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-O-sulfolactate + H2O = (R)-lactate + H(+) + sulfate
REACT:R-DRE-5649725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Danio rerio)
REACT:R-MMU-8867240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPCAM binds itself to form homotypic cell adhesion (Mus musculus)
REACT:R-HSA-8950608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression U2 small nuclear ribonucleoprotein A' (Homo sapiens)
RHEA:22944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH
RHEA:22944	skos:prefLabel	"3beta-hydroxy-5beta-steroid dehydrogenase"
RHEA:22944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3beta-hydroxy-5beta-steroid dehydrogenase"
RHEA:22944	skos:altLabel	"3beta-hydroxysteroid 5beta-progesterone oxidoreductase"
RHEA:22944	skos:altLabel	"3beta-hydroxysteroid 5beta-oxidoreductase"
REACT:R-MMU-5654677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR2 (Mus musculus)
REACT:R-RNO-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Rattus norvegicus)
REACT:R-DRE-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Danio rerio)
REACT:R-DRE-3323050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNRD2 catalyzes the reduction of TXN2 by NADPH (Danio rerio)
RHEA:10665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + perillyl alcohol => H(+) + NADH + perillyl aldehyde
RHEA:57965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => beta-myrcene + diphosphate
REACT:R-BTA-112342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of MAP2K1 by CDK1 (Bos taurus)
REACT:R-SSC-5691431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSMD14 cleaves K63-linked ubiquitin (Sus scrofa)
REACT:R-DDI-9014294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the plasma membrane (Dictyostelium discoideum)
REACT:R-RNO-390281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Rattus norvegicus)
REACT:R-BTA-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Bos taurus)
REACT:R-HSA-9611147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytic Uptake of HCMV Virion (Homo sapiens)
REACT:R-HSA-9694572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3a localizes to the cell membrane (Homo sapiens)
REACT:R-HSA-5654428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates SHC1 (Homo sapiens)
REACT:R-CEL-4551661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates RNF168 with SUMO1 (Caenorhabditis elegans)
REACT:R-DRE-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Danio rerio)
REACT:R-SPO-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)
RHEA:28582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dUDP = ADP + dUTP
REACT:R-CFA-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Canis familiaris)
RHEA:26140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O = 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)
RHEA:54476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)
REACT:R-HSA-4755545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective DHDDS does not elongate E,E-FPP (Homo sapiens)
REACT:R-DRE-5638012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D dissociates from ARL13B:INPP5E (Danio rerio)
RHEA:48270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	canthaxanthin + H2O => 4',4'-dihydroxyechinenone
RHEA:69857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in mRNA + H(+) + NADPH => a 5,6-dihydrouridine in mRNA + NADP(+)
REACT:R-HSA-6803917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates RGCC expression (Homo sapiens)
REACT:R-GGA-376884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose 6-phosphate [cytosol] => glucose 6-phosphate [endoplasmic reticulum lumen] (Gallus gallus)
REACT:R-HSA-1989777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of RGL1 (Homo sapiens)
REACT:R-HSA-8852019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET bound PI3K generates PIP3 (Homo sapiens)
RHEA:28994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminate(in) <=> N-acetylneuraminate(out)
REACT:R-CFA-374909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabolism of Noradrenaline (Canis familiaris)
RHEA:14279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + 2 H(+) + NADH => (S)-lactaldehyde + H2O + NAD(+)
REACT:R-RNO-3697882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN (Rattus norvegicus)
RHEA:63758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP => flavokermesate + UDP-alpha-D-glucose
REACT:R-BTA-8877813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND5A,B exchange GTP for GDP on RAB39 (Bos taurus)
GO:0033757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucoside 3-dehydrogenase activity
GO:0033757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexopyranoside-cytochrome c oxidoreductase
GO:0033757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aldohexoside:cytochrome c oxidoreductase
GO:0033757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aldohexoside:(acceptor) 3-oxidoreductase
GO:0033757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aldohexopyranoside dehydrogenase
GO:0033757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aldohexoside:acceptor 3-oxidoreductase
REACT:R-DRE-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Danio rerio)
REACT:R-RNO-445113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Urotensin-2 receptor binds urotensin-2 and 2B (Rattus norvegicus)
RHEA:30765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+) => H2O + L-valine + NAD(+)
RHEA:32374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin + 2 L-ascorbate <=> all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate
RHEA:41705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)
RHEA:51180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Danio rerio)
REACT:R-SSC-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Sus scrofa)
RHEA:21737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3,6-diaminohexanoate => (3S,5S)-3,5-diaminohexanoate
GO:0032551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine ribonucleoside binding
REACT:R-CFA-9009065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXA1 and GATA3 bind to CCND1 promoter (Canis familiaris)
RHEA:16236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + NADP(+) <=> 2-dehydropantoate + H(+) + NADPH
RHEA:59291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O <=> D-glucose + sphing-4-enine
REACT:R-DRE-9647746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 trimerizes (Danio rerio)
REACT:R-BTA-2562526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates OPTN (Bos taurus)
GO:0140643	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxymethylglutaryl coenzyme A reductase activity
GO:0140643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylglutaryl-CoA reductase (NADH) activity
GO:0140643	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity
GO:0140643	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	HMG-CoA reductase activity
GO:0140643	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-hydroxy-beta-methylglutaryl CoA-reductase activity
GO:0140643	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-hydroxy-3-methylglutaryl coenzyme A reductase activity
REACT:R-DME-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
REACT:R-RNO-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Rattus norvegicus)
EC:7.-.-.-	skos:prefLabel	"Translocases"
EC:7.-.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Translocases"
RHEA:65894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + xanthurenate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate
RHEA:45976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)
REACT:R-RNO-200421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of cytosolic AMPK by phosphorylation (Rattus norvegicus)
REACT:R-SSC-6804425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F2 (Sus scrofa)
RHEA:63887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + L-tyrosine <=> H2O + L-dopa
REACT:R-DRE-8875071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSS3 ligates CoA to CH3COO- (Danio rerio)
REACT:R-CEL-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Caenorhabditis elegans)
REACT:R-SSC-5362437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are bound by lectins (Sus scrofa)
REACT:R-DRE-936897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)
RHEA:58637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => (9Z)-octadecenamide + glyoxylate
GO:0008879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-glucose diphosphorylase activity
GO:0008879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphosphoglucose pyrophosphorylase activity
GO:0008879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymidine diphosphate glucose pyrophosphorylase activity
GO:0008879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-1-phosphate thymidylyltransferase activity
GO:0008879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-glucose pyrophosphorylase activity
GO:0008879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TDP-glucose pyrophosphorylase activity
GO:0008879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose 1-phosphate thymidylyltransferase activity
GO:0008879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity
GO:0008879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dTDP-glucose synthase activity
REACT:R-HSA-141348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAO:FAD oxidises NASPM to PTCN (Homo sapiens)
REACT:R-RNO-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Rattus norvegicus)
RHEA:10594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Danio rerio)
REACT:R-HSA-9023627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
RHEA:58722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide => (S)-nicotine + NADPH + O2
REACT:R-DRE-3134954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX9 binds DNA (Danio rerio)
REACT:R-HSA-2424487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
EC:3.5.1.100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-amidase"
EC:3.5.1.100	skos:altLabel	"R-stereospecific amidase"
EC:3.5.1.100	skos:prefLabel	"(R)-amidase"
EC:3.5.1.100	skos:altLabel	"R-amidase"
REACT:R-SSC-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Sus scrofa)
RHEA:16583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + 2 H2O => 2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2
RHEA:17675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine
RHEA:16687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl hexadecanoate + CoA => di-trans,poly-cis-dolichol + hexadecanoyl-CoA
REACT:R-CFA-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Canis familiaris)
RHEA:57527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)
REACT:R-HSA-5667008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds RHPN1 or RHPN2 (Homo sapiens)
RHEA:50255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H(+) + malonyl-CoA <=> a 3-oxoacyl-CoA + CO2 + CoA
REACT:R-CEL-5419273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of GTP and dissociation of 28S and 39S subunits (Caenorhabditis elegans)
REACT:R-HSA-4225086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective mitochondrial BTD does not hydrolyse BCTN (Homo sapiens)
RHEA:56260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose = 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP
GO:0043713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyisocaproate dehydrogenase activity
RHEA:71270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-pipecolate(out) + 2 Na(+)(out) <=> chloride(in) + L-pipecolate(in) + 2 Na(+)(in)
RHEA:64426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-leucyl-L-proline(in) => H(+)(out) + L-leucyl-L-proline(out)
REACT:R-MMU-5688289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Mus musculus)
GO:0015620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric-enterobactin transmembrane transporter activity
REACT:R-GGA-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Gallus gallus)
RHEA:16524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:17884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-sulfo-D-glucosamine <=> D-glucosamine + sulfate
RHEA:27365	skos:altLabel	"methyl chloride transferase"
RHEA:27365	skos:prefLabel	"methyl halide transferase"
RHEA:27365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methyl halide transferase"
RHEA:27365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + S-adenosyl-L-methionine = bromomethane + S-adenosyl-L-homocysteine
REACT:R-RNO-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Rattus norvegicus)
GO:0047821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamic acid oxidase activity
GO:0047821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamic oxidase activity
GO:0047821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate oxidase activity
GO:0047821	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glutamate:oxygen oxidoreductase (deaminating)
REACT:R-DDI-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)
REACT:R-HSA-9793988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates CFLAR at K351, K353 (Homo sapiens)
RHEA:21480	skos:altLabel	"furoyl-CoA hydroxylase"
RHEA:21480	skos:prefLabel	"2-furoyl-CoA dehydrogenase"
RHEA:21480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-furoyl-CoA dehydrogenase"
RHEA:21480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH2 + H(+)
RHEA:51170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine => (R)-adrenaline + H2O + O2
GO:0098623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)
GO:0098623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenite reductase activity
GO:0030395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose binding
RHEA:35611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menadiol + 2 O2 = 2 H(+) + menadione + 2 superoxide
REACT:R-HSA-399995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Muscarinic Acetylcholine Receptor M3 activates Gq (Homo sapiens)
REACT:R-RNO-5082384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70:DNAJB1 binds HSF1 (Rattus norvegicus)
GO:0102390	skos:prefLabel	"mycophenolic acid acyl-glucuronide esterase"
GO:0102390	skos:altLabel	"AcMPAG deglucuronidase"
GO:0102390	skos:altLabel	"mycophenolic acid acyl-glucuronide deglucuronidase"
GO:0102390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolic acid acyl-glucuronide esterase activity
GO:0102390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycophenolic acid acyl-glucuronide esterase"
GO:0102390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate
REACT:R-DRE-212004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Danio rerio)
RHEA:11349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite(in) + ATP + H2O => ADP + arsenite(out) + H(+) + phosphate
REACT:R-DRE-379044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gs-activating GPCR acts as a GEF for Gs (Danio rerio)
REACT:R-DDI-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Dictyostelium discoideum)
REACT:R-MMU-5099899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD4 (Mus musculus)
REACT:R-RNO-9009536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX5 binds ESR1:estrogen:TFF1 gene promoter (Rattus norvegicus)
EC:2.4.1.27	skos:prefLabel	"DNA beta-glucosyltransferase"
EC:2.4.1.27	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA beta-glucosyltransferase"
REACT:R-BTA-8983003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Bos taurus)
REACT:R-RNO-9680865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4, CYP2B6 bind ritonavir (Rattus norvegicus)
RHEA:12487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-phosphate + H2O <=> a ribonucleoside + phosphate
REACT:R-SPO-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Schizosaccharomyces pombe)
RHEA:37424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin N + O2 => aclacinomycin A + H2O2
RHEA:17497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formononetin + UDP-alpha-D-glucose = ononin + UDP
RHEA:15982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-methionine => CO2 + S-adenosyl 3-(methylsulfanyl)propylamine
REACT:R-MMU-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Mus musculus)
RHEA:17037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-acetaldehyde reductase (NADPH)"
RHEA:17037	skos:prefLabel	"indole-3-acetaldehyde reductase (NADPH)"
RHEA:17037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-ethanol + NADP(+) = H(+) + indole-3-acetaldehyde + NADPH
REACT:R-XTR-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Xenopus tropicalis)
REACT:R-HSA-2130725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
REACT:R-CFA-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Canis familiaris)
RHEA:12981	skos:prefLabel	"persulfide dioxygenase"
RHEA:12981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"persulfide dioxygenase"
RHEA:12981	skos:altLabel	"sulfur dioxygenase"
RHEA:12981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + S-sulfanylglutathione = glutathione + 2 H(+) + sulfite
RHEA:12981	skos:altLabel	"sulfur oxygenase"
RHEA:20973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine
REACT:R-HSA-2262777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to p-IRAK2   (Homo sapiens)
REACT:R-RNO-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Rattus norvegicus)
REACT:R-RNO-8867754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
RHEA:19705	skos:prefLabel	"hexadecanal dehydrogenase (acylating)"
RHEA:19705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hexadecanal dehydrogenase (acylating)"
RHEA:19705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanal + NAD(+) = H(+) + hexadecanoyl-CoA + NADH
RHEA:19705	skos:altLabel	"fatty acyl-CoA reductase"
REACT:R-HSA-5692785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO1 binds RAG gene (Homo sapiens)
RHEA:29230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + indole(in) <=> H(+)(out) + indole(out)
RHEA:34665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine
RHEA:72539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzaldehyde + H2O + NADP(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADPH
REACT:R-BTA-5205652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 recruits Parkin to the outer mitochondrial membrane. (Bos taurus)
REACT:R-DRE-4719436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO1 (Danio rerio)
REACT:R-HSA-8948136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 Translocates to the mitochondria (Homo sapiens)
RHEA:29677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol(out) => glycerol(in)
RHEA:70131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + taurocholate(out) <=> glutarate(out) + taurocholate(in)
RHEA:44681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)
REACT:R-CFA-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Canis familiaris)
REACT:R-CFA-71261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)
REACT:R-HSA-990528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PCBP2 with MAVS (Homo sapiens)
REACT:R-BTA-210290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHIP (Bos taurus)
RHEA:59743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + S-octadecanoyl-L-cysteinyl-[protein]
REACT:R-XTR-2022911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSPG is secreted (Xenopus tropicalis)
REACT:R-RNO-1306876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 activation by small molecules (Rattus norvegicus)
REACT:R-DDI-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)
RHEA:63433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)
REACT:R-RNO-1433501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other adapter proteins with p-KIT (Rattus norvegicus)
RHEA:59183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O <=> 2 AMP + H(+)
GO:0004664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prephenate dehydratase activity
GO:0004664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prephenate hydro-lyase (decarboxylating)
GO:0004664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)
REACT:R-DRE-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Danio rerio)
REACT:R-GGA-177920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2 to GAB1 (Gallus gallus)
REACT:R-HSA-3149434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of GAG to the Plasma Membrane (Homo sapiens)
REACT:R-DRE-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Danio rerio)
REACT:R-RNO-264758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Rattus norvegicus)
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcriptional activator activity, metal ion regulated sequence-specific DNA binding
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding
REACT:R-RNO-8854044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Rattus norvegicus)
RHEA:48195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-9694471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) (Homo sapiens)
REACT:R-RNO-8943003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH polyubiquitinates monoubiquitinated PCNA (Rattus norvegicus)
RHEA:28028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + UDP => [thioredoxin]-disulfide + dUDP + H2O
EC:3.2.1.38	skos:prefLabel	"beta-D-fucosidase"
EC:3.2.1.38	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-D-fucosidase"
RHEA:63886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-dopa => H2O2 + L-tyrosine
REACT:R-MMU-2530445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD59 inhibits MAC formation (Mus musculus)
GO:0019168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octaprenylphenol hydroxylase activity
REACT:R-PFA-5694071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Plasmodium falciparum)
RHEA:19356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate + H2O <=> cholate + glycine
RHEA:16084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-S-methyl-3-phospho-1-thioglycerate + H2O <=> (2R)-S-methyl-1-thioglycerate + phosphate
RHEA:64981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dZDP = ADP + dZTP
EC:3.4.19.2	skos:altLabel	"carboxyamidase"
EC:3.4.19.2	skos:altLabel	"peptidyl carboxyamidase"
EC:3.4.19.2	skos:prefLabel	"peptidyl-glycinamidase"
EC:3.4.19.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidyl-glycinamidase"
REACT:R-GGA-5358343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT palmitoylates Hh N-terminal fragment (Gallus gallus)
REACT:R-DRE-2574840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA facilitates AURKA autophosphorylation (Danio rerio)
REACT:R-SSC-5690740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds B-cell receptor (Sus scrofa)
RHEA:27955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => diphosphate + presilphiperfolan-8beta-ol
REACT:R-HSA-5228578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetX LC cleaves target cell VAMP2 (Homo sapiens)
RHEA:58700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + NADPH + rifampicin = FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal
RHEA:20038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol 6-phosphate + NADP(+) => aldehydo-D-glucose 6-phosphate + H(+) + NADPH
REACT:R-BTA-1168642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Bos taurus)
REACT:R-DRE-9629492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves spiroiminodihydantoin (Danio rerio)
REACT:R-HSA-1989745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ACADM (Homo sapiens)
REACT:R-CFA-5654402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
REACT:R-HSA-158744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Homo sapiens)
REACT:R-PFA-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Plasmodium falciparum)
RHEA:52893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nitrosobenzene => H(+) + NADPH + nitrobenzene
REACT:R-HSA-9710490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The GSDME gene promoter is hypermethylated (Homo sapiens)
REACT:R-CEL-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)
REACT:R-DME-5654399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS2 (Drosophila melanogaster)
RHEA:43019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-alkyl-L-cysteine <=> 2-aminoprop-2-enoate + an alkyl thiol
REACT:R-XTR-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Xenopus tropicalis)
REACT:R-CFA-5637686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)
GO:0036310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent DNA annealing activity
GO:0036310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA rewinding activity
GO:0036310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
GO:0036310	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	annealing helicase activity
GO:0036310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-triphosphatase activity involved in DNA annealing
GO:0036310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent DNA/DNA annealing activity
REACT:R-BTA-380294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of C-Nap-1 from centrosomes (Bos taurus)
REACT:R-DME-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Drosophila melanogaster)
REACT:R-GGA-8948228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Gallus gallus)
REACT:R-DME-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Drosophila melanogaster)
REACT:R-RNO-5654669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Rattus norvegicus)
GO:1990226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone methyltransferase binding
REACT:R-SSC-804969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B1 hydrogenates E1 to EST17b (Sus scrofa)
REACT:R-BTA-9707353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 binds Aromatase inhibitors (Bos taurus)
REACT:R-CFA-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Canis familiaris)
REACT:R-MMU-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Mus musculus)
REACT:R-RNO-5649801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Rattus norvegicus)
REACT:R-SSC-2024108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some HSPGs are secreted to the plasma membrane (Sus scrofa)
RHEA:13158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + CO2 + NADP(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH
REACT:R-HSA-3134946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 ubiquitination by TRIM21 (Homo sapiens)
REACT:R-DME-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Drosophila melanogaster)
GO:0005316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity inorganic phosphate:sodium symporter activity
GO:0005316	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium/phosphate cotransporter activity
GO:0005316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity inorganic phosphate:sodium symporter activity
RHEA:69434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine => 3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine
REACT:R-BTA-4551683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOPORS with SUMO1 (Bos taurus)
REACT:R-HSA-5661116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me3K5-histone H3 (Homo sapiens)
REACT:R-BTA-444047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR3 binds carboxylates (Bos taurus)
REACT:R-RNO-936942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Rattus norvegicus)
REACT:R-XTR-2025724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Xenopus tropicalis)
REACT:R-DRE-8865265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds MYC and KDM5B (Danio rerio)
GO:0102047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-glycine synthetase activity
REACT:R-BTA-176298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of claspin (Bos taurus)
RHEA:23647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]
RHEA:43370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA => dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA
REACT:R-RNO-8858270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HILPDA binds lipid droplets (Rattus norvegicus)
REACT:R-CFA-2179387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Canis familiaris)
REACT:R-HSA-448591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-32 binds proteinase-3 (Homo sapiens)
RHEA:68903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxybenzoate + ATP + H(+) + NADPH <=> 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)
RHEA:67341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + quercetin 3-O-beta-D-glucoside => CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)
REACT:R-CFA-2129353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin associates with microfibrils (Canis familiaris)
REACT:R-RNO-5676597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Rattus norvegicus)
REACT:R-HSA-9606887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)
RHEA:12835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + D-glutamate => an N-acyl-D-glutamate + H2O
RHEA:58929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,4R)-7,2',4'-trihydroxyisoflavanol => (6aR,11aR)-3,9-dihydroxypterocarpan + H2O
RHEA:19804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantetheine + ATP + H(+) <=> 3'-dephospho-CoA + diphosphate
REACT:R-GGA-2404199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:IGF1R autophosphorylates (Gallus gallus)
REACT:R-BTA-2065357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)
RHEA:42989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => cembrene C + diphosphate
REACT:R-HSA-9649963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC3 channel blockers bind ASIC3 trimer (Homo sapiens)
RHEA:10281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,7-dimethylxanthine + S-adenosyl-L-methionine => caffeine + H(+) + S-adenosyl-L-homocysteine
RHEA:14475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH => a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+)
RHEA:54059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-hedycaryol + diphosphate
GO:0004966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galanin receptor activity
REACT:R-GGA-159836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)
RHEA:28472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine(out) => pyridoxine(in)
RHEA:53610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+) => 4-hydroxyestrone + O2
RHEA:46646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH
REACT:R-XTR-73932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resynthesis of excised residue by POLB (Xenopus tropicalis)
RHEA:19661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannitol-1-phosphate 5-dehydrogenase"
RHEA:19661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH
RHEA:19661	skos:prefLabel	"mannitol-1-phosphate 5-dehydrogenase"
REACT:R-XTR-352379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Xenopus tropicalis)
REACT:R-CFA-4615987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO2,3 (Canis familiaris)
RHEA:48662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:38123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA
REACT:R-HSA-6804879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates TP53 (Homo sapiens)
REACT:R-HSA-1248655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)
REACT:R-RNO-1169394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of IRF3 (Rattus norvegicus)
GO:0047910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose 1-dehydrogenase (NADP+) activity
GO:0047910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactose:NADP+ 1-oxidoreductase activity
GO:0047910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-galactose dehydrogenase (NADP+)
GO:0047910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + NADP(+) = D-galactono-1,5-lactone + H(+) + NADPH
RHEA:70987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)
REACT:R-HSA-9757686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDL (Homo sapiens)
GO:0051735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP:5'-dephosphopolynucleotide 5'-phosphotransferase activity
GO:0051735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent polynucleotide 5'-hydroxyl-kinase activity
GO:0051735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-dependent polynucleotide kinase activity
REACT:R-PFA-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Plasmodium falciparum)
REACT:R-BTA-6804527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INTL1 binds bacterial glycans (Bos taurus)
REACT:R-MMU-71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)
RHEA:33249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline + H2O2 + NH4(+) => O2 + putrescine
RHEA:21320	skos:prefLabel	"D-sorbitol dehydrogenase (acceptor)"
RHEA:21320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-sorbitol dehydrogenase (acceptor)"
RHEA:21320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-sorbitol = AH2 + keto-L-sorbose
REACT:R-HSA-419426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cannabinoid receptors can bind cannabinoids (Homo sapiens)
REACT:R-SSC-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Sus scrofa)
RHEA:32357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + ternatin C5 + 2 UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose
REACT:R-XTR-977301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histidine is decarboxylated to histamine (Xenopus tropicalis)
REACT:R-HSA-164521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)
REACT:R-SSC-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)
REACT:R-SSC-193727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
REACT:R-SSC-429415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to integrin alphaIIb beta3 (Sus scrofa)
REACT:R-DRE-139897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAD displaces tBID from BCL-2 sequestration (Danio rerio)
RHEA:21521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b1] + formate => CO2 + 2 Fe(II)-[cytochrome b1] + H(+)
REACT:R-DRE-74716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin binds the insulin receptor (Danio rerio)
REACT:R-CFA-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Canis familiaris)
REACT:R-XTR-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Xenopus tropicalis)
REACT:R-GGA-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Gallus gallus)
RHEA:59660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotetraose + O2 = D-cellotetraono-1,5-lactone + H2O2
RHEA:52353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:51272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-octadecenoyl)glycine
REACT:R-MMU-430096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds filamin (Mus musculus)
REACT:R-SSC-1855180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Sus scrofa)
GO:0035275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibutyl phthalate binding
GO:0035275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBP binding
GO:0035275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phthalic acid dibutyl ester binding
RHEA:14742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylene-L-glutamine + H2O => 4-methylene-L-glutamate + NH4(+)
REACT:R-BTA-6794346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind NLGNs (Bos taurus)
RHEA:16162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[leghemoglobin] + NADH => 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)
REACT:R-RNO-3262512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Rattus norvegicus)
REACT:R-HSA-5682858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate H2AFX (Homo sapiens)
REACT:R-RNO-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Rattus norvegicus)
RHEA:31145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexanoyl-CoA + NAD(+)
REACT:R-CFA-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Canis familiaris)
REACT:R-MMU-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Mus musculus)
RHEA:48380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)
REACT:R-RNO-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Rattus norvegicus)
RHEA:14443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(3)-acetylgentamycin C => acetyl-CoA + gentamicin C
REACT:R-RNO-8849881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM2 associate with AMPA and NMDA receptors (Rattus norvegicus)
RHEA:13307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-sinapoyl)-beta-D-glucose + UDP => (E)-sinapate + UDP-alpha-D-glucose
REACT:R-SSC-174427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Sus scrofa)
RHEA:30540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinyl-CoA => (S)-carnitinyl-CoA
RHEA:69428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite + 3 glutathione + H(+) = arsenic triglutathione + 3 H2O
REACT:R-PFA-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Plasmodium falciparum)
REACT:R-SSC-5654167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds PLCG1 (Sus scrofa)
REACT:R-HSA-5683986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)
RHEA:58594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH
REACT:R-RNO-388829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 phosphatase binds CTLA-4 (Rattus norvegicus)
GO:0034823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citronellyl-CoA ligase activity
REACT:R-MMU-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Mus musculus)
RHEA:68085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-histidyl-[RNA ligase] => diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]
REACT:R-RNO-5690988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-incision of DNA by ERCC5 (XPG) in GG-NER (Rattus norvegicus)
RHEA:18276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + putrescine <=> 4-aminobutanal + H2O2 + NH4(+)
REACT:R-HSA-183055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to EGFR (Homo sapiens)
RHEA:44481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
RHEA:68245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(in) + Na(+)(in) => L-phenylalanine(out) + Na(+)(out)
REACT:R-XTR-8878143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SMAD3 and SMAD4 (Xenopus tropicalis)
REACT:R-DME-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Drosophila melanogaster)
REACT:R-HSA-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Homo sapiens)
REACT:R-HSA-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Homo sapiens)
REACT:R-DME-391375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Drosophila melanogaster)
RHEA:54190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-phenylalanine => H2O + N-acetyl-L-phenylalanine
RHEA:66795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-D-dopa + O2 <=> (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2
RHEA:66429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose(out) + H(+)(out) => D-arabinose(in) + H(+)(in)
RHEA:34252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxysphinganine + NADP(+) => 1-deoxy-3-dehydrosphinganine + H(+) + NADPH
RHEA:32919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl (indol-3-yl)acetate = (indol-3-yl)acetate + H(+) + methanol
GO:0102302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycinamicin VI 2''-O-methyltransferase activity
RHEA:17430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + trans-4-hydroxycyclohexanecarboxylate => 4-oxocyclohexanecarboxylate + H(+) + NADH
RHEA:21466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonyl sulfide + NH4(+) => 2 H(+) + H2O + thiocyanate
GO:0047110	skos:prefLabel	"phenylglyoxylate dehydrogenase (acylating)"
GO:0047110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylglyoxylate dehydrogenase (acylating)"
GO:0047110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO2 + NADH
GO:0047110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylglyoxylate dehydrogenase (acylating) activity
GO:0047110	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylglyoxylate:NAD+ oxidoreductase activity
RHEA:30938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nicotinate beta-D-ribonucleotide <=> beta-D-ribosylnicotinate + phosphate
REACT:R-HSA-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Homo sapiens)
RHEA:38273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA
RHEA:21581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate + H(+) => (R)-acetoin + CO2
REACT:R-GGA-433957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of recruited TAK1 (Gallus gallus)
REACT:R-BTA-5218841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
REACT:R-MMU-444848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 1 binds relaxin 3 (Mus musculus)
RHEA:52398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dihydroxyacetone phosphate + NADH => 4-O-phospho-D-threonate + NAD(+)
REACT:R-HSA-68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)
REACT:R-HSA-391377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone receptor can bind LH (Homo sapiens)
RHEA:53432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:57712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP
RHEA:19807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine nucleobase + alpha-D-ribose 1-phosphate => a purine D-ribonucleoside + phosphate
REACT:R-DRE-5610754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Danio rerio)
GO:0034280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity
GO:0034280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimaradiene synthase activity
GO:0034280	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ent-pimaradiene synthase activity
REACT:R-CFA-5654658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS bind to PPTN11 (Canis familiaris)
REACT:R-HSA-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Homo sapiens)
RHEA:50125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D1 => 8-oxoresolvin D1 + H(+) + NADH
REACT:R-DRE-8850560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha releases G-protein heterotrimer from PDCL  (Danio rerio)
RHEA:40287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + decanedioate = AMP + decanedioyl-CoA + diphosphate
REACT:R-HSA-5695980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD10 dehydrogenates S-2MPDA-CoA (Homo sapiens)
REACT:R-HSA-3787997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminin-332 binds collagen type VII (Homo sapiens)
REACT:R-PFA-6804527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INTL1 binds bacterial glycans (Plasmodium falciparum)
REACT:R-CFA-5621363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Canis familiaris)
REACT:R-CFA-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Canis familiaris)
RHEA:50454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E3 => prostaglandin H3
REACT:R-SSC-2559639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV sulfilimine cross-linking by peroxidasin (Sus scrofa)
REACT:R-DRE-202692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 binds to RhoA and activates it (Danio rerio)
REACT:R-CFA-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Canis familiaris)
RHEA:34485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzalacetone + 2 CO2 + 2 CoA => 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA
REACT:R-DRE-9750001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Danio rerio)
REACT:R-MMU-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Mus musculus)
REACT:R-XTR-3769383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBY1 binds beta-catenin (Xenopus tropicalis)
REACT:R-MMU-193682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves the p75NTR transmembrane domain (Mus musculus)
RHEA:39956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)
GO:0050302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IAAld oxidase activity
GO:0050302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IAA oxidase activity
GO:0050302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AO1
GO:0050302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-acetaldehyde:oxygen oxidoreductase activity
GO:0050302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(indol-3-yl)acetaldehyde:oxygen oxidoreductase activity
GO:0050302	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleacetaldehyde oxidase activity
GO:0050302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetaldehyde oxidase activity
REACT:R-DRE-6804266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TTC5 (Danio rerio)
RHEA:43448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:53218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-5666169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Rattus norvegicus)
RHEA:58834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2
RHEA:20044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H2O + NADP(+) <=> 2 H(+) + malonate + NADPH
REACT:R-HSA-2077420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)
REACT:R-CFA-205286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS interacts with p-KIT (Canis familiaris)
REACT:R-SPO-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Schizosaccharomyces pombe)
GO:0004946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bombesin receptor activity
RHEA:59472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP + H2O = Gp(2'-5')Ap(3') + H(+)
GO:0005484	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	R-SNARE activity
GO:0005484	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	t-SNARE activity
GO:0005484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNARE
GO:0005484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAP receptor activity
GO:0005484	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Q-SNARE activity
GO:0005484	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	SNAP-25
GO:0005484	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	v-SNARE activity
REACT:R-BTA-202165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)
RHEA:52566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-erythronate => 2-dehydro-L-erythronate
RHEA:10556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + L-arginine = H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate
RHEA:10556	skos:altLabel	"CEAS"
RHEA:10556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(2)-(2-carboxyethyl)arginine synthase"
RHEA:10556	skos:altLabel	"N(2)-(2-carboxyethyl)arginine synthetase"
RHEA:10556	skos:prefLabel	"N(2)-(2-carboxyethyl)arginine synthase"
RHEA:10556	skos:altLabel	"CEA synthetase"
REACT:R-CFA-429786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Canis familiaris)
RHEA:25847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5R)-carveol + NAD(+) <=> (R)-carvone + H(+) + NADH
RHEA:72760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A6 + malonyl-CoA => anthocyanin A8 + CoA
RHEA:48454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine => ganglioside GA2 (d18:1(4E)) + H2O
REACT:R-CEL-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocitrate dehydrogenase (NADP) kinase activity
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ICDH kinase/phosphatase activity
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[isocitrate dehydrogenase (NADP+)] kinase activity
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocitrate dehydrogenase (NADP+) kinase activity
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocitrate dehydrogenase kinase activity
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	IDH kinase/phosphatase activity
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isocitrate dehydrogenase kinase/phosphatase activity
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	IDHK/P
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IDH kinase activity
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocitrate dehydrogenase kinase (phosphorylating) activity
GO:0008772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IDH-K/P
REACT:R-RNO-6804441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF34 or RFFL ubiquitinates phosphorylated TP53 (Rattus norvegicus)
RHEA:60817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A14 aldehyde + O2 => CO2 + gibberellin A14 + H(+) + succinate
REACT:R-HSA-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)
REACT:R-DRE-2247513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1:ligand is endocytosed (Danio rerio)
RHEA:35824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + NAD(+) => 7,8-dihydromethanopterin + H(+) + NADH
GO:0050643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA
GO:0050643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetylbaccatin III 10-O-acetyltransferase activity
GO:0050643	skos:prefLabel	"10-deacetylbaccatin III 10-O-acetyltransferase"
GO:0050643	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetyl-CoA:taxan-10beta-ol O-acetyltransferase
GO:0050643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"10-deacetylbaccatin III 10-O-acetyltransferase"
RHEA:39893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + H(+) + vancomycin => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine
RHEA:61291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-ribose + ATP <=> 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)
REACT:R-MMU-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Mus musculus)
REACT:R-HSA-6787533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Homo sapiens)
RHEA:58709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin ortho-naphthoquinone carboxamide => rifampicin para-naphthoquinone carboxamide
RHEA:51011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome cL] + methanol <=> 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)
RHEA:63771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine
REACT:R-BTA-203712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS associates with Caveolin-1 (Bos taurus)
REACT:R-PFA-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Plasmodium falciparum)
REACT:R-DME-1855180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Drosophila melanogaster)
RHEA:56947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + D-ribulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + H2O
EC:2.1.1.159	skos:prefLabel	"theobromine synthase"
EC:2.1.1.159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"theobromine synthase"
EC:2.1.1.159	skos:altLabel	"monomethylxanthine methyltransferase"
EC:2.1.1.159	skos:altLabel	"MXMT"
RHEA:52352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Canis familiaris)
RHEA:55513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9686013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nsp3:nsp4 binds to nsp6 (Homo sapiens)
REACT:R-CEL-77299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)
RHEA:16597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate
REACT:R-RNO-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Rattus norvegicus)
RHEA:25818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal + H2O2 + norspermidine => H2O + norspermine + O2
REACT:R-MMU-9021357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCI phosphorylates ELF3 (Mus musculus)
RHEA:40346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecanedioyl-CoA + CoA <=> acetyl-CoA + tetradecanedioyl-CoA
REACT:R-DDI-5423647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)
GO:0000210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)
GO:0000210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ phosphohydrolase activity
GO:0000210	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD diphosphatase activity
GO:0000210	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD pyrophosphatase activity
GO:0000210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ pyrophosphatase activity
GO:0000210	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP pyrophosphatase activity
GO:0000210	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide pyrophosphatase activity
GO:0000210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ diphosphatase activity
GO:0000210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) pyrophosphatase activity
REACT:R-XTR-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Xenopus tropicalis)
REACT:R-SCE-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Saccharomyces cerevisiae)
REACT:R-GGA-375340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 62 mediated neuronal gap junction communication (Gallus gallus)
REACT:R-MMU-8875071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSS3 ligates CoA to CH3COO- (Mus musculus)
REACT:R-HSA-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Homo sapiens)
REACT:R-CFA-3341343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)
REACT:R-XTR-1592371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP3 (Xenopus tropicalis)
REACT:R-HSA-2395340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxyallysine by LOX (Homo sapiens)
REACT:R-CFA-8939201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR dimerizes (Canis familiaris)
RHEA:67233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH
REACT:R-CEL-2022860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Caenorhabditis elegans)
GO:0031795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled GABA receptor binding
GO:0031795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled GABA receptor binding
GO:0031795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metabotropic GABA receptor binding
GO:0031795	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metabotropic GABA receptor ligand
GO:0031795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB receptor binding
RHEA:50342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone
RHEA:66642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + koraiol => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-DRE-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Danio rerio)
RHEA:58520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Drosophila melanogaster)
EC:4.4.1.4	skos:prefLabel	"alliin lyase"
EC:4.4.1.4	skos:altLabel	"cysteine sulphoxide lyase"
EC:4.4.1.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alliin lyase"
EC:4.4.1.4	skos:altLabel	"cysteine sulfoxide lyase"
EC:4.4.1.4	skos:altLabel	"alliinase"
EC:4.4.1.4	skos:altLabel	"L-cysteine sulfoxide lyase"
GO:0106363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein cysteine methylase activity
GO:0106363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]
GO:0106363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein cysteine methyltransferase activity
GO:0106363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-cysteine methyltransferase activity
REACT:R-XTR-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Xenopus tropicalis)
REACT:R-SSC-5623525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo-carrying vesicles bud from the TGN (Sus scrofa)
REACT:R-DRE-140791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Danio rerio)
RHEA:50031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine
RHEA:66192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + bilirubin-bisglucuronoside(in) + H2O = ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate
GO:0018538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxide carboxylase activity
REACT:R-MMU-1296035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Mus musculus)
REACT:R-DME-214395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monomeric PGN bound PGRP-LE oligomerises in the cytosol (Drosophila melanogaster)
GO:0047545	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-hydroxyglutarate dehydrogenase (NAD+ specific)
GO:0047545	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase
GO:0047545	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyglutaric dehydrogenase activity
GO:0047545	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-hydroxyglutarate oxidoreductase activity
GO:0047545	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase
GO:0047545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate dehydrogenase activity
GO:0047545	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alpha-hydroxyglutarate dehydrogenase activity
GO:0047545	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-hydroxyglutarate dehydrogenase activity
GO:0047545	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase
REACT:R-RNO-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Rattus norvegicus)
RHEA:63579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone 22-phosphate + H2O <=> ecdysone + phosphate
RHEA:14170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + glutarate => ADP + glutaryl-CoA + phosphate
RHEA:37767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-RNO-5649711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 incises DNA strand 5' to the AP site (Rattus norvegicus)
REACT:R-BTA-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Bos taurus)
RHEA:25472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + gamma-himachalene
REACT:R-DRE-8983307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL15RA (Danio rerio)
REACT:R-SPO-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Schizosaccharomyces pombe)
RHEA:42041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose => gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)
REACT:R-HSA-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Homo sapiens)
REACT:R-CEL-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Caenorhabditis elegans)
RHEA:53674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2
REACT:R-GGA-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Gallus gallus)
REACT:R-BTA-6781922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 binds UFD1L:SKP2 (Bos taurus)
REACT:R-BTA-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Bos taurus)
REACT:R-DRE-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Danio rerio)
GO:0050682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AF-2 domain binding
GO:0039630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA translocase activity
REACT:R-HSA-3928612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KALRN exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
RHEA:45414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + prostaglandin D2 => H2O + prostaglandin D2-1-glycerol ester
RHEA:31382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyrrole-2-carboxylate <=> 1H-pyrrole + hydrogencarbonate
REACT:R-HSA-1500761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitrogen dioxide is reduced to NO by F420 (Homo sapiens)
GO:0005198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural molecule activity
REACT:R-DME-5666104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Drosophila melanogaster)
GO:0015517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose:hydrogen symporter activity
GO:0015517	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lactose, galactose:hydrogen symporter activity
GO:0015517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose:proton symporter activity
REACT:R-DRE-450333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Danio rerio)
RHEA:15622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP
GO:0070975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FHA domain binding
GO:0070975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Forkhead-associated domain binding
RHEA:15594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amicoumacin A 2-phosphate + H2O => amicoumacin A + phosphate
RHEA:39108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
REACT:R-DDI-8952251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Dictyostelium discoideum)
RHEA:52781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => 2-sulfenohercynine + NH4(+) + pyruvate
RHEA:53052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + UDP-alpha-D-glucuronate = 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-SSC-76466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4A11 12-hydroxylates DDCX (Sus scrofa)
RHEA:67404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:24042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [cytochrome P450] => NADPH + 2 oxidized [cytochrome P450]
REACT:R-CFA-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Canis familiaris)
REACT:R-CFA-209765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
REACT:R-SSC-199144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin 2 binds CD226 (Sus scrofa)
REACT:R-BTA-706479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated (Bos taurus)
REACT:R-SSC-9759259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2 dehydrogenates PREDL to PREDN (Sus scrofa)
REACT:R-CFA-5624948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF17 enters the cilium (Canis familiaris)
GO:0033832	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity
GO:0033832	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	trehalose phosphorylase activity
GO:0033832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose phosphorylase (configuration-retaining) activity
RHEA:34943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) = arbutin 6-phosphate(in) + pyruvate(in)
REACT:R-MMU-8938073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Mus musculus)
REACT:R-XTR-2161899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Xenopus tropicalis)
EC:1.5.1.20	skos:prefLabel	"methylenetetrahydrofolate reductase [NAD(P)H]"
EC:1.5.1.20	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylenetetrahydrofolate reductase [NAD(P)H]"
EC:1.5.1.20	skos:altLabel	"MTHFR"
GO:0061135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endopeptidase regulator activity
REACT:R-HSA-5626316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)
REACT:R-DRE-751039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (12/13) reassociates with G beta:gamma (Danio rerio)
RHEA:15276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-dopa <=> 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate
REACT:R-SSC-9629216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Sus scrofa)
RHEA:28291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (5S,9S,10S)-drim-7-en-11-ol + diphosphate
REACT:R-MMU-6800797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome activates CASP2 (Mus musculus)
REACT:R-MMU-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Mus musculus)
REACT:R-CEL-8849463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates SFPQ (Caenorhabditis elegans)
REACT:R-HSA-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Homo sapiens)
REACT:R-XTR-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Xenopus tropicalis)
RHEA:29772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate(in) + ATP + H2O => ADP + arsenate(out) + H(+) + phosphate
RHEA:34191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)
REACT:R-BTA-5696220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to arsenite(3-) (Bos taurus)
RHEA:49177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine
RHEA:52559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-D-erythronate + ATP <=> 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)
GO:0033734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-benzylsuccinyl-CoA dehydrogenase activity
GO:0033734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity
GO:0033734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity
GO:0033734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BbsG
REACT:R-DDI-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Dictyostelium discoideum)
RHEA:21825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate
REACT:R-RNO-1605632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Both hexosaminidase A and B can cleave GalNAc from globoside (Rattus norvegicus)
RHEA:18291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate => (S,S)-tartrate
REACT:R-HSA-141341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMOX-3 oxidises SPN to SPM (Homo sapiens)
RHEA:71310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-valine(out) + 2 Na(+)(out) <=> chloride(in) + L-valine(in) + 2 Na(+)(in)
REACT:R-HSA-9714959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to TNF(1-233) trimer (Homo sapiens)
RHEA:70453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate => 2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2
REACT:R-DRE-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Danio rerio)
RHEA:65657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cholest-1,4-dien-3-one + H2O => 25-hydroxycholest-1,4-dien-3-one + AH2
REACT:R-MMU-192341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)
RHEA:17661	skos:prefLabel	"succinate--CoA ligase (ADP-forming)"
RHEA:17661	skos:altLabel	"succinyl-CoA synthetase (ADP-forming)"
RHEA:17661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinate--CoA ligase (ADP-forming)"
RHEA:17661	skos:altLabel	"succinate thiokinase"
RHEA:17661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
REACT:R-DME-997237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B proteins bind JAK2 (Drosophila melanogaster)
RHEA:12081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + CoA
REACT:R-DDI-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)
REACT:R-BTA-5687120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Bos taurus)
RHEA:53366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NAD(+)
RHEA:51639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + selenite <=> a quinol + selenate
RHEA:72755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 ATP = 3',3',3'-c-tri-AMP + 3 diphosphate
GO:0098606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenocystathionine gamma-lyase activity
REACT:R-CEL-3002811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates PLK1 (Caenorhabditis elegans)
REACT:R-RNO-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
REACT:R-SSC-5652151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 recruits POLZ to (AP:Cyt)-DNA Template (Sus scrofa)
RHEA:19366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribulose 5-phosphate => ADP + D-ribulose 1,5-bisphosphate + H(+)
GO:0034074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	marneral synthase activity
GO:0034074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"marneral synthase"
GO:0034074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = marneral
GO:0034074	skos:prefLabel	"marneral synthase"
RHEA:20284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate <=> (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)
REACT:R-GGA-6798528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Mn2+ (Gallus gallus)
RHEA:21967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acylcholine + H2O <=> a carboxylate + choline + H(+)
REACT:R-MMU-9022314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates MECP2 (Mus musculus)
GO:0005133	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-gamma receptor ligand
GO:0005133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II interferon receptor binding
GO:0005133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interferon-gamma receptor binding
GO:0005133	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-gamma
REACT:R-XTR-8939706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) polyubiquitinates RUNX2 (Xenopus tropicalis)
RHEA:50413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] => H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)
REACT:R-SPO-194023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2,HSD11B1 dimer oxidise CORT to COR (Schizosaccharomyces pombe)
GO:0102075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPC4-trans-2-enoyl-CoA hydratase activity
REACT:R-SPO-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Schizosaccharomyces pombe)
REACT:R-XTR-9035227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN2 binds CysS248-MPST (Xenopus tropicalis)
RHEA:68622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH
REACT:R-BTA-5654573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds SHC1 (Bos taurus)
GO:0016175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	superoxide-generating NAD(P)H oxidase activity
GO:0016175	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome B-245
REACT:R-XTR-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Xenopus tropicalis)
REACT:R-GGA-6800315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 binds MST1R (Gallus gallus)
REACT:R-CFA-1168638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated IKK phosphorylates I-kappaB (Canis familiaris)
RHEA:47152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate + H2O + NAD(+) = 2-oxoglutarate + 2 H(+) + NADH
GO:0050223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protocatechuate decarboxylase activity
GO:0050223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protocatechuate decarboxylase"
GO:0050223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocatechuate carboxy-lyase activity
GO:0050223	skos:altLabel	"3,4-dihydroxybenzoate decarboxylase"
GO:0050223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)
GO:0050223	skos:altLabel	"protocatechuate carboxy-lyase"
GO:0050223	skos:prefLabel	"protocatechuate decarboxylase"
GO:0050223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydrobenzoate decarboxylase activity
GO:0050223	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxybenzoate decarboxylase activity
GO:0050223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + H(+) = catechol + CO2
REACT:R-DDI-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Dictyostelium discoideum)
GO:0000700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mismatch base pair DNA N-glycosylase activity
RHEA:15334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + NADP(+) => H(+) + N-carbamoyl-2-oxoglycine + NADPH
GO:0005147	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oncostatin-M receptor ligand
GO:0005147	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oncostatin-M
GO:0005147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oncostatin-M receptor binding
REACT:R-SSC-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Sus scrofa)
REACT:R-HSA-1307955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds HS:KLB:FGF19 (Homo sapiens)
RHEA:38884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP + CoA => a fatty acyl-CoA + AMP + diphosphate
REACT:R-RNO-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Rattus norvegicus)
REACT:R-DRE-158893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Danio rerio)
REACT:R-DME-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Drosophila melanogaster)
RHEA:53255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-2534087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMT1/2 transfer MYS to GNAT1 (Canis familiaris)
RHEA:32595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate + H(+)
RHEA:56138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a phenolic radical donor + 2 H2O => 2 a phenolic donor + H2O2
RHEA:62165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O => D-glucosamine + N-acetyl-D-glucosamine
REACT:R-MMU-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Mus musculus)
RHEA:18975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-deacetylvindoline + CO2 + succinate => 2-oxoglutarate + deacetoxyvindoline + O2
REACT:R-MMU-5654592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)
RHEA:65067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + siccayne <=> diphosphate + pestalodiol
REACT:R-MMU-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Mus musculus)
REACT:R-CEL-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Caenorhabditis elegans)
RHEA:19635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+) => (3S,5S)-3,5-diaminohexanoate + H2O + NAD(+)
REACT:R-DRE-9633044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR binds STRN (Danio rerio)
REACT:R-RNO-5662662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosinase oxidises tyrosine to dopaquinone (Rattus norvegicus)
GO:0047129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) = H(+) + L-2-aminopentanoate + NADH + pyruvate
GO:0047129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)
GO:0047129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)
GO:0047129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	opine dehydrogenase activity
GO:0047129	skos:prefLabel	"opine dehydrogenase"
GO:0047129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"opine dehydrogenase"
RHEA:28704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(in) => Cu(2+)(out)
REACT:R-DME-8878914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Drosophila melanogaster)
REACT:R-DME-8865613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Drosophila melanogaster)
RHEA:57679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-191784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA Cap hypermethylation (Danio rerio)
REACT:R-BTA-114354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC binds XIAP:Caspase-7 (Bos taurus)
RHEA:17341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH
REACT:R-SPO-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Schizosaccharomyces pombe)
REACT:R-HSA-8868260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5:p25 phosphorylates GOLGA2 (Homo sapiens)
REACT:R-BTA-4551649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO1 (Bos taurus)
REACT:R-BTA-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Bos taurus)
REACT:R-CFA-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)
REACT:R-DRE-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Danio rerio)
REACT:R-MMU-749456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
REACT:R-MMU-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Mus musculus)
REACT:R-HSA-211186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DFF45 (224) by caspase-3 (Homo sapiens)
REACT:R-MMU-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Mus musculus)
RHEA:34556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH
REACT:R-XTR-2855020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Xenopus tropicalis)
REACT:R-DME-8952069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 deacetylates RUNX3 (Drosophila melanogaster)
RHEA:50325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid ester + H2O <=> a fatty acid + an aliphatic alcohol + H(+)
EC:1.1.1.38	skos:altLabel	"malic enzyme"
EC:1.1.1.38	skos:prefLabel	"malate dehydrogenase (oxaloacetate-decarboxylating)"
EC:1.1.1.38	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malate dehydrogenase (oxaloacetate-decarboxylating)"
EC:1.1.1.38	skos:altLabel	"NAD-malic enzyme"
EC:1.1.1.38	skos:altLabel	"pyruvic-malic carboxylase"
REACT:R-RNO-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Rattus norvegicus)
REACT:R-XTR-9707504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 oxidises ferrohemoglobin to MetHb (Xenopus tropicalis)
REACT:R-CFA-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Canis familiaris)
REACT:R-DRE-9627056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procaspase 9 forms dimer (Danio rerio)
REACT:R-HSA-9016526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2-P2 binds RUNX2 gene promoter (Homo sapiens)
REACT:R-MMU-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Mus musculus)
REACT:R-MMU-3000339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BORA binds SCF-beta-TrCp1/2 (Mus musculus)
GO:0018479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzaldehyde:NAD+ oxidoreductase activity
GO:0018479	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzaldehyde (NAD) dehydrogenase activity
GO:0018479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde dehydrogenase (NAD+) activity
RHEA:49892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2
GO:0001681	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate acetyltransferase activity
GO:0001681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialate O-acetylesterase activity
GO:0001681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialate 9(4)-O-acetylesterase activity
GO:0001681	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-O-acetylneuraminate O-acetylhydrolase activity
REACT:R-CEL-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Caenorhabditis elegans)
REACT:R-DRE-9769235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGED1 binds NPAS4 (Danio rerio)
REACT:R-SSC-170847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
REACT:R-CFA-6814695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PERP binds desmosomes (Canis familiaris)
REACT:R-BTA-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Bos taurus)
REACT:R-CFA-2468041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Canis familiaris)
REACT:R-DME-209891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine is oxidised to noradrenaline (Drosophila melanogaster)
REACT:R-HSA-373734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin interacts with Podocin (Homo sapiens)
RHEA:56675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-4-coumaroyl-CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH
REACT:R-XTR-210277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-1 (Xenopus tropicalis)
REACT:R-XTR-8983371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Xenopus tropicalis)
REACT:R-CFA-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Canis familiaris)
RHEA:46559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 <=> 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0047306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine:pyruvate aminotransferase activity
GO:0047306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methionine-pyruvate transaminase activity
GO:0047306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methionine-pyruvate aminotransferase activity
GO:0047306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine transaminase activity
GO:0047306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine--pyruvate aminotransferase activity
GO:0047306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine aminotransferase activity
REACT:R-MMU-9661408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Mus musculus)
RHEA:43088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine
RHEA:44926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihomocitrate + CoA + H(+) => 2-oxoadipate + acetyl-CoA + H2O
GO:0035014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K regulator activity
GO:0035014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoinositide 3-kinase regulator activity
GO:0035014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol 3-kinase regulator activity
RHEA:43044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecasphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylhexadecasphinganine
RHEA:32328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxy-alpha-humulene + NAD(+) => H(+) + NADH + zerumbone
RHEA:58639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z-octadecenoyl)-(2S)-hydroxyglycine <=> (9Z)-octadecenamide + glyoxylate
REACT:R-DME-109700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT2 binds PIP3 (Drosophila melanogaster)
REACT:R-CFA-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Canis familiaris)
REACT:R-RNO-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Rattus norvegicus)
REACT:R-DME-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Drosophila melanogaster)
REACT:R-CFA-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Canis familiaris)
REACT:R-MMU-5672961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates inactive RAFs (Mus musculus)
RHEA:53719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP <=> phosphate + UDP-N-acetyl-alpha-D-muramate
REACT:R-DME-1250220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of ERBB4 (Drosophila melanogaster)
REACT:R-SSC-9670101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATRX:DAXX binds to subtelomeric chromosomal regions (Sus scrofa)
RHEA:23402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+) => 7,8-dihydroxykynurenate + O2
GO:0015638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microcin transmembrane transporter activity
GO:0015638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microcin uptake permease activity
GO:0016628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0016628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Homo sapiens)
REACT:R-MMU-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Mus musculus)
REACT:R-DME-8854604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D16 accelerates GTP hydrolysis by RAB4A (Drosophila melanogaster)
REACT:R-XTR-9010815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLITs bind keratan sulfate (Xenopus tropicalis)
EC:3.4.17.6	skos:prefLabel	"alanine carboxypeptidase"
EC:3.4.17.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alanine carboxypeptidase"
REACT:R-BTA-5218952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)
REACT:R-CFA-2730867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
REACT:R-DRE-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Danio rerio)
REACT:R-GGA-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Gallus gallus)
REACT:R-CEL-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Caenorhabditis elegans)
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glucopyranosidase activity
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lysosomal alpha-glucosidase activity
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosidosucrase activity
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glucosidase II
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucoside glucohydrolase activity
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-glucosidase activity
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosidoinvertase activity
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acid maltase activity
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,4-glucosidase activity
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltase-glucoamylase activity
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucoinvertase activity
GO:0004558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-glucoside hydrolase activity
REACT:R-DRE-8849345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Danio rerio)
RHEA:40827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
REACT:R-XTR-71050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of the FASL:FAS receptor complex (Xenopus tropicalis)
REACT:R-CFA-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Canis familiaris)
REACT:R-HSA-9006422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3 (Homo sapiens)
REACT:R-CFA-9029690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-6 translocates to the nucleus (Canis familiaris)
RHEA:39611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)
REACT:R-XTR-5665982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Xenopus tropicalis)
REACT:R-BTA-183067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Localization of CBL:GRB2 to the membrane (Bos taurus)
REACT:R-BTA-5654643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
RHEA:72882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-(2-amino-1-hydroxyethyl)phosphonate <=> NH4(+) + phosphonoacetaldehyde
REACT:R-MMU-166038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-bound CD14 binds LPS (Mus musculus)
RHEA:15522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycyl-[protein]
RHEA:17563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + choline + H(+) => acetylcholine + H2O
RHEA:15634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + O2 => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)
REACT:R-HSA-1268025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAM50 complex inserts proteins into mitochondrial outer membrane (Homo sapiens)
REACT:R-MMU-8857555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates GPNMB (Mus musculus)
RHEA:21704	skos:prefLabel	"tyrosine phenol-lyase"
RHEA:21704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine phenol-lyase"
RHEA:21704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tyrosine = NH4(+) + phenol + pyruvate
RHEA:21704	skos:altLabel	"beta-tyrosinase"
RHEA:36890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O
REACT:R-HSA-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Homo sapiens)
REACT:R-RNO-8855508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Rattus norvegicus)
REACT:R-RNO-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Rattus norvegicus)
RHEA:22113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)
REACT:R-HSA-164515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusogenic activation of gp41 (Homo sapiens)
RHEA:67727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP(out) + CMP-N-acetyl-beta-neuraminate(in) <=> CMP(in) + CMP-N-acetyl-beta-neuraminate(out)
REACT:R-MMU-211948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 can N-demethylate loperamide (Mus musculus)
RHEA:45002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-3-hydroxybutanoyl-(R)-carnitine => (R)-carnitine + 3-hydroxybutanoyl-CoA
REACT:R-MMU-389639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Mus musculus)
RHEA:64755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanylpentan-1-ol-L-cysteine + H2O <=> 3-sulfanyl-1-pentanol + NH4(+) + pyruvate
EC:1.14.13.247	skos:prefLabel	"stachydrine N-demethylase"
EC:1.14.13.247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stachydrine N-demethylase"
EC:1.14.13.247	skos:altLabel	"L-proline betaine N-demethylase"
REACT:R-MMU-8852013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL8 binds resting T cell surface (Mus musculus)
GO:0047333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity
GO:0047333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrostreptomycin-6-phosphate 3'alpha-kinase activity
GO:0047333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity
GO:0047333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity
GO:0047333	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrostreptomycin 6-phosphate kinase (phosphorylating)
REACT:R-RNO-5624494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 binds p21 RAS:GTP (Rattus norvegicus)
GO:0008234	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thiol protease activity
GO:0008234	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cysteine protease activity
GO:0008234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type peptidase activity
GO:0008234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
REACT:R-MMU-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Mus musculus)
REACT:R-HSA-8983378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)
RHEA:51675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + H2O <=> glycolate + H(+)
REACT:R-SPO-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Schizosaccharomyces pombe)
REACT:R-XTR-9603986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 chains to form LeA (Xenopus tropicalis)
RHEA:10450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavone + CO2 + H2O + succinate => 2-oxoglutarate + a flavanone + O2
REACT:R-CFA-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Canis familiaris)
RHEA:18311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + a D-alpha-amino acid => an N-acyl-D-amino acid + H2O
REACT:R-MMU-9681294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6R binds IL6R inhibitors (Mus musculus)
REACT:R-DME-192056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Drosophila melanogaster)
RHEA:69317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate => allyl thiocyanate + sulfate
REACT:R-GGA-9757574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDL (Gallus gallus)
RHEA:48949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-RNO-5690856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Rattus norvegicus)
REACT:R-XTR-5651789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to POLB ligates SSB (Xenopus tropicalis)
REACT:R-DRE-168947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand binds to TLR10 (Danio rerio)
REACT:R-GGA-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Gallus gallus)
REACT:R-CFA-2730904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Canis familiaris)
RHEA:66164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + serotonin = CoA + H(+) + N-butanoylserotonin
REACT:R-BTA-266050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to LTC4 by LTC4S (Bos taurus)
REACT:R-SPO-2162186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeMQ10H2 is methylated to Q10H2 by COQ3 (Schizosaccharomyces pombe)
REACT:R-XTR-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Xenopus tropicalis)
REACT:R-DRE-3238999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Danio rerio)
RHEA:54366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin => 2 acetaldehyde
REACT:R-RNO-373074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR9  binds CCL25 ligand (Rattus norvegicus)
REACT:R-BTA-5693549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Bos taurus)
RHEA:66587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocholestane + A + H2O <=> 25-hydroxy 3-oxocholestane + AH2
RHEA:54897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,15Z)-12-oxophytodienoate + ATP + CoA => (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate
RHEA:47430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+)
RHEA:15521	skos:prefLabel	"glycylpeptide N-tetradecanoyltransferase"
RHEA:15521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
RHEA:15521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycylpeptide N-tetradecanoyltransferase"
RHEA:15521	skos:altLabel	"peptide N-myristoyltransferase"
RHEA:15521	skos:altLabel	"peptide N-tetradecanoyltransferase"
RHEA:13878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-ornithine => an L-alpha-amino acid + L-glutamate 5-semialdehyde
REACT:R-MMU-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Mus musculus)
REACT:R-XTR-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Xenopus tropicalis)
GO:0061711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-L-threonylcarbamoyladenine synthase activity
REACT:R-HSA-9665705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 (Homo sapiens)
RHEA:49998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]
RHEA:37677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol
RHEA:54663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic (S)-hydroxynitrile <=> an aromatic aldehyde + hydrogen cyanide
RHEA:68974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dihydroxyacetone phosphate => A + sn-glycerol 3-phosphate
REACT:R-DRE-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Danio rerio)
RHEA:60033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GTP + H2O => 8-oxo-GDP + H(+) + phosphate
RHEA:47170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+)
RHEA:71763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + citrate(in) = 2-oxoglutarate(in) + citrate(out)
REACT:R-GGA-1295604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-RAF dissociates from S111/S120 p-SPRY2 (Gallus gallus)
RHEA:36187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
REACT:R-HSA-113638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)
REACT:R-CFA-8944240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type III (Canis familiaris)
REACT:R-HSA-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Homo sapiens)
RHEA:65575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Homo sapiens)
REACT:R-DRE-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Danio rerio)
REACT:R-HSA-158750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Homo sapiens)
REACT:R-GGA-209063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Gallus gallus)
RHEA:65816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate
RHEA:65816	skos:prefLabel	"[Co(II) methylated amine-specific corrinoid protein] reductase"
RHEA:65816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[Co(II) methylated amine-specific corrinoid protein] reductase"
REACT:R-RNO-2530429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of soluble VTN:C5b-C9  (Rattus norvegicus)
RHEA:61847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solasodine + UDP-alpha-D-glucose <=> H(+) + solasodine 3-beta-D-glucoside + UDP
RHEA:25449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-guaia-6,9-diene + diphosphate
REACT:R-SSC-8853753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Sus scrofa)
REACT:R-SSC-158744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Sus scrofa)
RHEA:47254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]
RHEA:31141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)
RHEA:48015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-5-nitrocatechol + NADPH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite
RHEA:33688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-N-debenzoyltaxol + benzoyl-CoA => CoA + H(+) + taxol
REACT:R-RNO-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Rattus norvegicus)
GO:0016769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring nitrogenous groups
GO:0016769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring nitrogenous groups"
GO:0016769	skos:prefLabel	"Transferring nitrogenous groups"
GO:0016769	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transferase activity, transferring other nitrogenous groups
RHEA:32956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate
REACT:R-SSC-4420206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SRC-1 (Sus scrofa)
RHEA:68576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + xanthine(out) = ADP + H(+) + phosphate + xanthine(in)
REACT:R-XTR-8852362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds CDKN1A (Xenopus tropicalis)
REACT:R-SPO-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
RHEA:12175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucosamine 6-phosphate + H2O <=> beta-D-fructose 6-phosphate + NH4(+)
RHEA:44460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine
REACT:R-CFA-201634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of FADK 1 (Canis familiaris)
REACT:R-BTA-8931653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Bos taurus)
REACT:R-CFA-419426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cannabinoid receptors can bind cannabinoids (Canis familiaris)
REACT:R-CEL-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Caenorhabditis elegans)
REACT:R-DRE-5649673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyA from damaged DNA (Danio rerio)
RHEA:35317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-CoA + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-CoA
REACT:R-GGA-5696491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNTF binds CNTFR complex (Gallus gallus)
REACT:R-GGA-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Gallus gallus)
REACT:R-CFA-190681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in endoplasmic reticulum membrane (Canis familiaris)
REACT:R-SCE-383190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCO3- transport through ion channel (Saccharomyces cerevisiae)
REACT:R-DME-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Drosophila melanogaster)
REACT:R-DRE-141139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of TRAIL:TRAIL receptor complex (Danio rerio)
REACT:R-RNO-2162019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to EXA4 by ALOX15 (Rattus norvegicus)
REACT:R-RNO-5634103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 dissociates from atRA:RAR:RXR (Rattus norvegicus)
RHEA:57545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1
REACT:R-GGA-433099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS2 co-transports sulphate and two sodium ions (Gallus gallus)
REACT:R-HSA-2213017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF3 (Homo sapiens)
RHEA:12822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate => acetaldehyde + D-glyceraldehyde 3-phosphate
REACT:R-MMU-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Mus musculus)
REACT:R-CEL-4085083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Caenorhabditis elegans)
REACT:R-CEL-382054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binds to extracellular matrix proteins (Caenorhabditis elegans)
REACT:R-GGA-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Gallus gallus)
REACT:R-GGA-8851679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR183 binds 7alpha,25-dihydroxycholesterol (Gallus gallus)
GO:0034862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxybenzothiazole monooxygenase activity
REACT:R-BTA-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Bos taurus)
RHEA:10991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nitrous oxide <=> 2 e(-) + 2 H(+) + 2 nitric oxide
REACT:R-MMU-3828025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP14 (Mus musculus)
GO:0043898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybiphenyl-1,2-dioxygenase activity
GO:0043898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybiphenyl 1,2-dioxygenase activity
GO:0043898	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BphC
GO:0050588	skos:prefLabel	"8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase"
GO:0050588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-beta-carotenoid-14',13'-dioxygenase activity
GO:0050588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-b-carotenoid-14',13'-dioxygenase activity
GO:0050588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase"
GO:0050588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	8'-apo-beta-carotenol:O2 oxidoreductase activity
GO:0050588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8'-apo-beta-carotenol + O2 = (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal
RHEA:14168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-aspartate <=> CoA + H(+) + N-acetyl-L-aspartate
RHEA:38136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-CEL-3323050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNRD2 catalyzes the reduction of TXN2 by NADPH (Caenorhabditis elegans)
REACT:R-XTR-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Xenopus tropicalis)
RHEA:34703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (E)-2-epi-beta-caryophyllene + diphosphate
RHEA:34703	skos:prefLabel	"(E)-2-epi-beta-caryophyllene synthase"
RHEA:34703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(E)-2-epi-beta-caryophyllene synthase"
RHEA:34703	skos:altLabel	"2-epi-(E)-beta-caryophyllene synthase"
REACT:R-XTR-167433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta-gamma subunits rebind the alpha-GDP subunit (Xenopus tropicalis)
REACT:R-CFA-451366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38MAPK by DSCAM (Canis familiaris)
RHEA:45431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate
REACT:R-RNO-2029451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Rattus norvegicus)
GO:0102586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity
RHEA:51822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in) => ATP(in) + CoA(in) + decanoate(out) + H(+)(out)
RHEA:62602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2
REACT:R-HSA-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Homo sapiens)
REACT:R-CEL-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Caenorhabditis elegans)
GO:0034832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranial dehydrogenase activity
RHEA:68927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + hexanoate + NADPH <=> AMP + diphosphate + hexanal + NADP(+)
RHEA:37931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate
RHEA:54821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-CFA-9023968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Canis familiaris)
REACT:R-HSA-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Homo sapiens)
RHEA:12180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthranilate N-methyltransferase"
RHEA:12180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + S-adenosyl-L-methionine = H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine
RHEA:12180	skos:prefLabel	"anthranilate N-methyltransferase"
REACT:R-SSC-9705738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Sus scrofa)
RHEA:27304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloro-L-tryptophan + O2
RHEA:61515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malvidin + UDP-alpha-D-glucose <=> malvidin 3-O-beta-D-glucoside + UDP
RHEA:15081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + CoA = acetyl-CoA + ADP + phosphate
RHEA:15081	skos:altLabel	"acetate thiokinase"
RHEA:15081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + propanoate = ADP + phosphate + propanoyl-CoA
RHEA:15081	skos:prefLabel	"acetate--CoA ligase (ADP-forming)"
RHEA:15081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetate--CoA ligase (ADP-forming)"
RHEA:15081	skos:altLabel	"acetyl-CoA synthetase (ADP-forming)"
EC:2.4.1.161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligosaccharide 4-alpha-D-glucosyltransferase"
EC:2.4.1.161	skos:altLabel	"alpha-1,4-transglucosylase"
EC:2.4.1.161	skos:altLabel	"amylase III"
EC:2.4.1.161	skos:prefLabel	"oligosaccharide 4-alpha-D-glucosyltransferase"
RHEA:11646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2R,3R)-flavan-3-ol + 2 NADP(+)
RHEA:48208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-RNO-140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Rattus norvegicus)
REACT:R-CEL-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Caenorhabditis elegans)
REACT:R-RNO-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Rattus norvegicus)
RHEA:62351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide C
REACT:R-GGA-173512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Gallus gallus)
REACT:R-CEL-8852019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET bound PI3K generates PIP3 (Caenorhabditis elegans)
REACT:R-HSA-1183003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Leptin (Homo sapiens)
REACT:R-DRE-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Danio rerio)
RHEA:60151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate
RHEA:61182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + quercetin 3-O-beta-D-glucoside + UDP => quercetin + UDP-alpha-D-glucose
GO:0016040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate (reduced nicotinamide adenine dinucleotide) synthase
GO:0016040	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-glutamate synthase activity
GO:0016040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-glutamate synthase activity
GO:0016040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH: GOGAT
GO:0016040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:NAD+ oxidoreductase (transaminating)
GO:0016040	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-glutamate synthetase activity
GO:0016040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate synthase (NADH)
GO:0016040	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GOGAT activity
GO:0016040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dependent glutamate synthase activity
GO:0016040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate synthase (NADH) activity
REACT:R-XTR-143468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEOS oxidizes ethanol to acetaldehyde (Xenopus tropicalis)
RHEA:51583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) <=> a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
RHEA:70901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate
RHEA:31020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 => 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O
REACT:R-HSA-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Homo sapiens)
REACT:R-HSA-109480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Homo sapiens)
REACT:R-HSA-9007901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RL2 (Homo sapiens)
RHEA:14324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	morphine + NADP(+) <=> H(+) + morphinone + NADPH
RHEA:52270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + S-adenosyl-L-methionine
RHEA:51582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out)
REACT:R-MMU-3341296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX7,8 catalyze peroxidation of P4HB (PDI) (Mus musculus)
REACT:R-MMU-4085331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-1 SUMOylates PARK7 with SUMO1 (Mus musculus)
REACT:R-BTA-163843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-GAS6 to GAS6 (Bos taurus)
REACT:R-GGA-352946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + glyceraldehyde 3-phosphate (Gallus gallus)
REACT:R-XTR-6801762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A oligomerize to form a pore complex (Xenopus tropicalis)
RHEA:15916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine phosphate <=> ADP + thiamine diphosphate
GO:0033463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine tRNA
GO:0033463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGA codon-amino acid adaptor activity
REACT:R-MMU-209815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is monoiodinated (Mus musculus)
REACT:R-MMU-4084984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Mus musculus)
REACT:R-GGA-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)
REACT:R-CEL-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Caenorhabditis elegans)
RHEA:52780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(hercyn-2-yl)-L-cysteine S-oxide = 2-sulfenohercynine + NH4(+) + pyruvate
REACT:R-SCE-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Saccharomyces cerevisiae)
REACT:R-DRE-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Danio rerio)
REACT:R-MMU-1562641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)
RHEA:16141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + NAD(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADH
RHEA:30318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,7-dimethylxanthine + H(+) + NADH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)
REACT:R-HSA-2424252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds collagen, fibronectin, aggrecan and matrilins (Homo sapiens)
REACT:R-BTA-3640858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase ADP-ribosylates AXIN (Bos taurus)
REACT:R-CFA-174425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Canis familiaris)
REACT:R-HSA-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Homo sapiens)
RHEA:30362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 <=> chlorophyllide b + 3 H2O + 2 NADP(+)
RHEA:45328	skos:prefLabel	"7,8-dihydroneopterin epimerase"
RHEA:45328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7,8-dihydroneopterin epimerase"
RHEA:45328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin = 7,8-dihydromonapterin
RHEA:42153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine
REACT:R-BTA-1963582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB2 heterodimers (Bos taurus)
REACT:R-HSA-8932322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates NFE2L2 (Homo sapiens)
REACT:R-RNO-170846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 recruits TGFBR1 (Rattus norvegicus)
REACT:R-BTA-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Bos taurus)
REACT:R-XTR-8849435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 dephosphorylates PTK6 (Xenopus tropicalis)
RHEA:15222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)
RHEA:67177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + primary fluorescent dioxobilin-type chlorophyll catabolite => H(+) + methanol + O13(4)-desmethyl pFDCC
REACT:R-RNO-622415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 binds NEMO (Rattus norvegicus)
REACT:R-DRE-6785898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R binds JAK2 (Danio rerio)
REACT:R-GGA-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Gallus gallus)
RHEA:50665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-HSA-163769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PP2A by Xylulose-5-phosphate (Homo sapiens)
REACT:R-MMU-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Mus musculus)
RHEA:67089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + tetracosanoate(in) => ADP + H(+) + phosphate + tetracosanoate(out)
RHEA:58207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)
RHEA:17690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + glycochenodeoxycholate => adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)
REACT:R-GGA-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Gallus gallus)
RHEA:37710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
GO:0034815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity
REACT:R-HSA-2263492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HGSNAT does not acetylate Heparan chain(1) (Homo sapiens)
REACT:R-HSA-70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Homo sapiens)
RHEA:52476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D-glucuronate) + H(+) + UDP
GO:0050251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinol isomerase activity
GO:0050251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol isomerase activity
GO:0050251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol 11-cis-trans-isomerase activity
GO:0031796	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 metabotropic GABA receptor ligand
GO:0031796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 metabotropic GABA receptor binding
REACT:R-BTA-77615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR2) (Bos taurus)
GO:0051499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aminoacyl-tRNA deacylase activity
GO:0033039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salty taste receptor activity
REACT:R-DRE-176517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to PREG (Danio rerio)
REACT:R-XTR-265429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Xenopus tropicalis)
RHEA:56149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sn-glycerol 3-phosphocholine => CoA + hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:46115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-73646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
RHEA:26288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-5B + S-adenosyl-L-methionine <=> Co-precorrin-6A + S-adenosyl-L-homocysteine
RHEA:21812	skos:altLabel	"cholesterol 7alpha-hydroxylase"
RHEA:21812	skos:prefLabel	"cholesterol 7alpha-monooxygenase"
RHEA:21812	skos:altLabel	"CYP7A1"
RHEA:21812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholesterol 7alpha-monooxygenase"
RHEA:21812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:58558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(16S)-deshydroxymethyl-stemmadenine + formate => 15alpha-stemmadenine intermediate II + H2O
RHEA:45749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hexenoyl-CoA => (2E)-hexenoyl-CoA
RHEA:49849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid ketone + a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)
GO:0102969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-oxogeraniol oxidoreductase activity
RHEA:56485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] => gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-163691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ChREBP at Serine 568 by AMPK (Homo sapiens)
RHEA:64234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O => 8 H(+) + holo-[ACP] + 8 malonyl-CoA
RHEA:62790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurasperone B + 2 H2O + NADP(+) => 2 fonsecin B + H(+) + NADPH + O2
GO:0043808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lyso-ornithine lipid acyltransferase activity
RHEA:54597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + hexadecanoyl-CoA + O2 => 2-hydroxyhexadecanoyl-CoA + CO2 + succinate
REACT:R-BTA-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Bos taurus)
RHEA:38527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)
RHEA:49105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester
RHEA:63169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + L-cysteine => S-(2-succino)-L-cysteine
RHEA:58943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + diphosphate + NAD(+)
REACT:R-HSA-1606583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Homo sapiens)
GO:0005519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal regulatory protein binding
RHEA:68812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate = beta-bisabolene + diphosphate
RHEA:68657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxocholesterol + H(+) + NADPH => 7beta-hydroxycholesterol + NADP(+)
GO:0008470	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methylbutanoyl-CoA:acceptor oxidoreductase activity
GO:0008470	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity
GO:0008470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA dehydrogenase activity
GO:0008470	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isovaleroyl-coenzyme A dehydrogenase activity
GO:0008470	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isovaleryl-coenzyme A dehydrogenase activity
RHEA:71182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(out) + L-tryptophan(in) <=> L-histidine(in) + L-tryptophan(out)
RHEA:18930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + thiophene-2-carbonyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O
RHEA:25708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-dihomomethionine
REACT:R-CEL-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Caenorhabditis elegans)
REACT:R-MMU-3858482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is recruited to the receptor (Mus musculus)
REACT:R-DME-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Drosophila melanogaster)
RHEA:68612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin E1 = NADP(+) + prostaglandin F1
RHEA:66579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 4-isopropylphenol <=> 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:22765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
REACT:R-DRE-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)
REACT:R-XTR-209925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIT and MIT combine to form triiodothyronine (Xenopus tropicalis)
RHEA:24597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-histidine => CoA + H(+) + N(alpha)-acetyl-L-histidine
REACT:R-DRE-5666008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCAI binds SRF:MKL1 (Danio rerio)
REACT:R-CEL-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Caenorhabditis elegans)
REACT:R-RNO-9647680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP1 cleaves GSDMD (Rattus norvegicus)
REACT:R-DDI-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)
RHEA:63023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienamide + H2O <=> (9Z,12Z)-octadecadienoate + NH4(+)
REACT:R-PFA-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Plasmodium falciparum)
RHEA:12723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-methyl-5'-thioadenosine + spermidine => putrescine + S-adenosyl 3-(methylsulfanyl)propylamine
RHEA:26059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[methylamine--corrinoid protein] Co-methyltransferase"
RHEA:26059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine = methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)
RHEA:26059	skos:altLabel	"monomethylamine methyltransferase"
RHEA:26059	skos:prefLabel	"[methylamine--corrinoid protein] Co-methyltransferase"
REACT:R-SPO-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Schizosaccharomyces pombe)
REACT:R-BTA-193646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF binding to p75NTR inactivates RHOA (Bos taurus)
REACT:R-BTA-879674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD97 binds CD55 (Bos taurus)
REACT:R-GGA-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Gallus gallus)
REACT:R-DME-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Drosophila melanogaster)
RHEA:46731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2
RHEA:23484	skos:altLabel	"cellobiose dehydrogenase"
RHEA:23484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-cellobiose = AH2 + D-cellobiono-1,5-lactone
RHEA:23484	skos:altLabel	"CDH"
RHEA:23484	skos:altLabel	"cellobiose dehydrogenase (quinone)"
RHEA:23484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellobiose dehydrogenase (acceptor)"
RHEA:23484	skos:altLabel	"cellobiose-quinone oxidoreductase"
RHEA:23484	skos:altLabel	"cellobiose oxidoreductase"
RHEA:23484	skos:prefLabel	"cellobiose dehydrogenase (acceptor)"
RHEA:23484	skos:altLabel	"CBOR"
RHEA:23484	skos:altLabel	"cellobiose oxidase"
REACT:R-DDI-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Dictyostelium discoideum)
REACT:R-DRE-9755303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades HIFalpha (Danio rerio)
REACT:R-MMU-5696197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Mus musculus)
REACT:R-HSA-9640316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DeHA hydrolyses to threonate and oxalate (Homo sapiens)
RHEA:13800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + H2O <=> di-trans,poly-cis-dolichol + phosphate
RHEA:71655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O = a thymidine in DNA + ADP-D-ribose
REACT:R-GGA-2173318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5a anaphylatoxin binds C5a receptor (Gallus gallus)
RHEA:68560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate + D-glyceraldehyde 3-phosphate + NAD(+) = 1-arsono-3-phospho-D-glycerate + H(+) + NADH
RHEA:68560	skos:prefLabel	"glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)"
RHEA:68560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)"
GO:0034542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylarsine oxidase activity
REACT:R-CFA-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Canis familiaris)
REACT:R-CFA-9614271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ADGRG6 (Canis familiaris)
RHEA:61790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-tryptophan
REACT:R-DRE-5263614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeOH is reduced to MeSeH by TXNRD1 (Danio rerio)
RHEA:51446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine
REACT:R-BTA-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Bos taurus)
RHEA:50710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione
REACT:R-DRE-3222593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B demethylates H3K27me3 on p16INK4A promoter (Danio rerio)
REACT:R-HSA-75146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Homo sapiens)
REACT:R-CFA-176116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of Chk1 (Canis familiaris)
REACT:R-CEL-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Caenorhabditis elegans)
REACT:R-DDI-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)
RHEA:52770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate => 2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O
RHEA:60015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA with a 3' CC end + ATP <=> a tRNA with a 3' CCA end + diphosphate
REACT:R-CEL-1482689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)
REACT:R-DRE-5693575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PKcs autophosphorylates (Danio rerio)
REACT:R-DRE-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Danio rerio)
RHEA:55311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-HSA-5660530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SNCB (Homo sapiens)
RHEA:29227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + indole(in) = H(+)(out) + indole(out)
REACT:R-DME-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Drosophila melanogaster)
REACT:R-SPO-113409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of early transcription elongation by DSIF:NELF (Schizosaccharomyces pombe)
GO:0051722	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphatase methylesterase activity
GO:0051722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Homo sapiens)
GO:0051722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein C-terminal methylesterase activity
RHEA:54526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhexane-2,5-dione + CO2 => acetoacetate + H(+) + methylglyoxal
REACT:R-RNO-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)
RHEA:16239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-peptidylproline (omega=0) => [protein]-peptidylproline (omega=180)
REACT:R-CEL-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Caenorhabditis elegans)
RHEA:20960	skos:altLabel	"phytate 6-phosphatase"
RHEA:20960	skos:prefLabel	"4-phytase"
RHEA:20960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-phytase"
RHEA:20960	skos:altLabel	"6-phytase (name based on 1L-numbering system and not 1D-numbering)"
RHEA:20960	skos:altLabel	"phytase"
RHEA:20960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate
REACT:R-BTA-429157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 accumulation of dense granule contents (Bos taurus)
REACT:R-GGA-5683967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Gallus gallus)
REACT:R-HSA-5617143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)
REACT:R-RNO-5690991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Rattus norvegicus)
REACT:R-DDI-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Dictyostelium discoideum)
REACT:R-CEL-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Caenorhabditis elegans)
RHEA:49369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate
RHEA:21266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + glyoxylate => A + glycolate
REACT:R-SPO-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-SSC-3132753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pancreatic proteases degrade TCN1:RCbl (Sus scrofa)
GO:0015136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sialic acid transmembrane transporter activity
REACT:R-XTR-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Xenopus tropicalis)
RHEA:46883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP
REACT:R-XTR-1067676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST-2 (Xenopus tropicalis)
RHEA:41480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + episterol = an episterol ester + CoA
RHEA:16358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + succinate => AH2 + fumarate
REACT:R-MMU-8936214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCY2C trimer binds GUCA2A,B (Mus musculus)
RHEA:12846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O => [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate
RHEA:64443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycylglycyl-L-proline(out) + H(+)(out) <=> glycylglycyl-L-proline(in) + H(+)(in)
RHEA:70551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose = 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP
RHEA:60703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline
REACT:R-BTA-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)
REACT:R-MMU-5623521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)
REACT:R-SSC-8851797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 in ADRB2:GRK complex is phosphorylated (Sus scrofa)
REACT:R-DRE-873919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Danio rerio)
RHEA:56653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
REACT:R-SCE-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Saccharomyces cerevisiae)
REACT:R-XTR-2161795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Xenopus tropicalis)
RHEA:48532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GQ1c (d18:1(4E)) + H2O = ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate
REACT:R-RNO-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Rattus norvegicus)
EC:4.1.99.13	skos:altLabel	"DNA photolyase"
EC:4.1.99.13	skos:prefLabel	"(6-4)DNA photolyase"
EC:4.1.99.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(6-4)DNA photolyase"
RHEA:68132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytol + tetradecanoyl-CoA = CoA + tetradecanoate phytyl ester
REACT:R-RNO-9629918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 translocates to the nucleus (Rattus norvegicus)
RHEA:58682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + FAD + H(+) => A + FADH2
REACT:R-CEL-192312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Caenorhabditis elegans)
REACT:R-HSA-5655702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)
RHEA:44661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thyroid oxidase activity
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dual oxidase activity
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thyroid NADPH oxidase activity
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p138tox
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thyroid oxidase 2 activity
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)H oxidase H2O2-forming activity
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADPH oxidase
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NAD(P)H oxidase activity
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:oxygen oxidoreductase activity
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ThOX activity
GO:0016174	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	THOX2 activity
RHEA:52094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-hexadecenoyloxy)-octadecanoate + H2O
GO:0102031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamido-4,6-dideoxy-D-galactose transferase activity
REACT:R-HSA-77271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Homo sapiens)
REACT:R-RNO-158893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Rattus norvegicus)
RHEA:66672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) = 5,7-dihydroxy-4-methylphthalide + H2O
GO:0016494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-X-C chemokine receptor activity
REACT:R-BTA-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Bos taurus)
RHEA:63131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-docosanoyl-ethanolamine <=> docosanoate + ethanolamine
REACT:R-SSC-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Sus scrofa)
RHEA:44171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + 2 H(+) + NADH <=> dodecanal + H2O + NAD(+)
REACT:R-GGA-1592316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP1 (Gallus gallus)
RHEA:61158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + GDP + H(+) => 3'-dephospho-CoA + GTP
REACT:R-MMU-9686930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is cleaved by CASP8 (Mus musculus)
REACT:R-SSC-9717206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Sus scrofa)
RHEA:38604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) => 2'-phospho-cyclic ADP-ribose + nicotinamide
RHEA:52915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dimethylallyl-4-hydroxymandelate + O2 <=> 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O
RHEA:58826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
GO:0031698	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-2 adrenergic receptor ligand
GO:0031698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-2 adrenergic receptor binding
RHEA:69917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(in) + 2 Na(+)(in) => guanosine(out) + 2 Na(+)(out)
REACT:R-GGA-3928617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB2 binds KALRN (Gallus gallus)
REACT:R-HSA-1678708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(2) (Homo sapiens)
RHEA:30140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanoyl-CoA => CoA + H(+) + octadecanoate
RHEA:48648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-PFA-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)
REACT:R-BTA-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Bos taurus)
RHEA:48759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythritol + NAD(+) <=> D-erythrulose + H(+) + NADH
GO:1990594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-talarate dehydratase"
GO:1990594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-altrarate dehydratase activity
GO:1990594	skos:altLabel	"L-talarate hydro-lyase"
GO:1990594	skos:prefLabel	"L-talarate dehydratase"
GO:1990594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O
GO:1990594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-talarate dehydratase activity
REACT:R-MMU-1614362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Mus musculus)
REACT:R-HSA-4093330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHB binds p120-RasGAP (Homo sapiens)
REACT:R-RNO-5623524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The exocyst complex binds to RAB3IP in the ciliary targeting complex (Rattus norvegicus)
REACT:R-BTA-5578883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Bos taurus)
RHEA:65293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + butan-2-one + 3 H2O + hydrogencarbonate => 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate
REACT:R-RNO-212710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR activates PLC-gamma1 by phosphorylation (Rattus norvegicus)
GO:0004483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0004483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	messenger RNA (nucleoside-2'-)-methyltransferase activity
GO:0004483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0004483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)
GO:0004483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mRNA (adenosine-2'-O-)-methyltransferase activity
GO:0004483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	messenger ribonucleate nucleoside 2'-methyltransferase activity
RHEA:27602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]"
RHEA:27602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate
RHEA:27602	skos:prefLabel	"trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]"
REACT:R-HSA-8938150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds the PRKCQ gene promoter (Homo sapiens)
GO:0140083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent protein-DNA unloader activity
GO:0140083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent protein-DNA unloading activity
GO:0140083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-DNA unloading ATPase activity
RHEA:46278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + CO2 => (S)-malate + H(+)
REACT:R-RNO-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Rattus norvegicus)
REACT:R-CFA-9706298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CSK (Canis familiaris)
RHEA:11173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine => (6S)-5,6,7,8-tetrahydrofolate + L-methionine
REACT:R-MMU-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Mus musculus)
REACT:R-XTR-5654416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:pFRS binds GRB2:SOS1 (Xenopus tropicalis)
RHEA:52085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-octadecanoyloxy-octadecanoate + H2O => 13-hydroxy-octadecanoate + H(+) + octadecanoate
REACT:R-XTR-5688797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 family cleave Ub chains (Xenopus tropicalis)
REACT:R-CFA-373342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3CR1 binds CX3CL1 (Canis familiaris)
REACT:R-HSA-9031518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the APOC1 gene (Homo sapiens)
EC:1.13.12.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)"
EC:1.13.12.-	skos:prefLabel	"With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)"
RHEA:45424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:35330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxodocosanoyl-CoA + CO2 + CoA
REACT:R-XTR-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Xenopus tropicalis)
RHEA:17667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein] => L-lysyl-[protein] + octanoyl-[ACP]
RHEA:24682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + NADP(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH
RHEA:63414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O => 2,4,6-trichlorophenol + FADH2 + O2
RHEA:63804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-gulose = GDP-beta-L-galactose
RHEA:51391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dopamine <=> CoA + H(+) + N-acetyl-dopamine
REACT:R-HSA-167630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Nef CD28 cytoplasmic tail complex (Homo sapiens)
REACT:R-SCE-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Saccharomyces cerevisiae)
REACT:R-CFA-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Canis familiaris)
REACT:R-SSC-9757578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDN (Sus scrofa)
RHEA:61436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H2O = AMP + H(+) + phosphate
RHEA:38543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] = (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]
RHEA:60913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine
REACT:R-XTR-174446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap from the C-strand (Xenopus tropicalis)
REACT:R-PFA-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)
RHEA:36265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + O-ureido-L-serine => hydroxyurea + O-acetyl-L-serine
REACT:R-BTA-1602458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP10 (Bos taurus)
RHEA:22176	skos:altLabel	"LTB4 omega-hydroxylase"
RHEA:22176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leukotriene-B4 20-monooxygenase"
RHEA:22176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:22176	skos:altLabel	"LTB4 20-hydroxylase"
RHEA:22176	skos:prefLabel	"leukotriene-B4 20-monooxygenase"
RHEA:22176	skos:altLabel	"leukotriene-B4 20-hydroxylase"
RHEA:22176	skos:altLabel	"leucotriene-B4 omega-hydroxylase"
RHEA:22176	skos:altLabel	"CYP4F3"
RHEA:22176	skos:altLabel	"CYP4F2"
RHEA:42212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
REACT:R-MMU-177937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of EGFR by SRC kinase (Mus musculus)
REACT:R-GGA-4719436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO1 (Gallus gallus)
RHEA:16756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)
RHEA:20771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphonopyruvate + H(+) <=> CO2 + phosphonoacetaldehyde
REACT:R-SSC-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Sus scrofa)
RHEA:23198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine => 3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine
RHEA:64170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + formaldehyde => 2-ethyl-L-serine
RHEA:34284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-tyrosine + O2 => 2 L-dopa
REACT:R-SSC-5422942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXRA:PPARD binds FABP5:atRA (Sus scrofa)
GO:0004818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamyl-tRNA synthetase activity
GO:0004818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-tRNA ligase activity
GO:0004818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:tRNAGlu ligase (AMP-forming) activity
GO:0004818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic acid translase activity
GO:0004818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamyl-transfer ribonucleate synthetase activity
GO:0004818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamyl-transfer RNA synthetase activity
GO:0004818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate-tRNA synthetase activity
GO:0004818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamyl-transfer ribonucleic acid synthetase activity
RHEA:54062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-DDI-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Dictyostelium discoideum)
REACT:R-CFA-202174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ZAP-70 (Canis familiaris)
REACT:R-XTR-419490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATP to P2X receptors (Xenopus tropicalis)
REACT:R-CFA-5683930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WICH phosphorylates H2AFX on Y142 (Canis familiaris)
REACT:R-HSA-9705466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT1,3,5 dimer enhances expression of SOCS1 (Homo sapiens)
REACT:R-CFA-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Canis familiaris)
RHEA:25707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-dihomomethionine => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O
REACT:R-CFA-158849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phenol can form a sulfate conjugate (Canis familiaris)
RHEA:37346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 2'-phosphate + H2O <=> adenosine + phosphate
REACT:R-MMU-2730882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC-theta (Mus musculus)
RHEA:60656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline
RHEA:43828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-BTA-182969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:CBL) (Bos taurus)
REACT:R-CFA-9607301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2 binds SOS1 (Canis familiaris)
REACT:R-GGA-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
RHEA:41561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 => (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O
REACT:R-RNO-112342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of MAP2K1 by CDK1 (Rattus norvegicus)
RHEA:43707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + tetradecanoate <=> diphosphate + tetradecanoyl-AMP
REACT:R-CFA-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Canis familiaris)
REACT:R-DRE-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)
REACT:R-RNO-170131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Rattus norvegicus)
RHEA:21280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 O2 + thiamine = H(+) + 2 H2O2 + thiamine acetate
RHEA:21280	skos:prefLabel	"thiamine oxidase"
RHEA:21280	skos:altLabel	"thiamine dehydrogenase"
RHEA:21280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiamine oxidase"
REACT:R-MMU-217255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO1:FAD N-oxidises TAM (Mus musculus)
RHEA:19959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 9-riburonosylhypoxanthine + 2 H(+) => 2 5'-dehydroinosine + O2
RHEA:60288	skos:prefLabel	"[histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase"
RHEA:60288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:60288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase"
GO:0008807	skos:altLabel	"CPEP phosphonomutase"
GO:0008807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxyphosphonoenolpyruvate phosphonomutase activity
GO:0008807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPEP phosphonomutase activity
GO:0008807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-carboxyvinyl carboxyphosphonate + H(+) = 3-(hydrohydroxyphosphoryl)pyruvate + CO2
GO:0008807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyvinyl-carboxyphosphonate phosphorylmutase activity
GO:0008807	skos:prefLabel	"carboxyvinyl-carboxyphosphonate phosphorylmutase"
GO:0008807	skos:altLabel	"carboxyphosphonoenolpyruvate phosphonomutase"
GO:0008807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)
GO:0008807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxyvinyl-carboxyphosphonate phosphorylmutase"
REACT:R-BTA-9693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds 5HT (Bos taurus)
REACT:R-SCE-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Saccharomyces cerevisiae)
REACT:R-BTA-5690990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Bos taurus)
REACT:R-HSA-6782859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) (Homo sapiens)
REACT:R-BTA-74101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerization of 11c-retinyl to at-retinyl (Bos taurus)
REACT:R-RNO-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Rattus norvegicus)
REACT:R-SSC-74737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-IRS1,p-Y-IRS2 bind PI3K (Sus scrofa)
GO:0016866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mutase activity
GO:0016866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular transferase activity
GO:0016866	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intramolecular transferase activity, transferring other groups
GO:0016866	skos:prefLabel	"Intramolecular transferases"
GO:0016866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Intramolecular transferases"
REACT:R-BTA-193060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
RHEA:51293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(S)-S-oxide-[protein]
RHEA:54516	skos:prefLabel	"manoyl oxide synthase"
RHEA:54516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"manoyl oxide synthase"
RHEA:54516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate
RHEA:35133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-alanyl-L-glutamate(in) => H(+)(out) + L-alanyl-L-glutamate(out)
REACT:R-DME-9011595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Drosophila melanogaster)
RHEA:36399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3beta-ol + NADP(+) = H(+) + NADPH + zymosterol
REACT:R-BTA-6805638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A acetylates TP53 (Bos taurus)
RHEA:43671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hexacosanoyl-CoA + hydrogencarbonate <=> 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate
EC:2.3.2.12	skos:prefLabel	"peptidyltransferase"
EC:2.3.2.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidyltransferase"
REACT:R-DRE-1604360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP14 (Danio rerio)
REACT:R-HSA-3371582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 binds HSF1 trimer (Homo sapiens)
REACT:R-DRE-3215310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53 and counteracts MDM2 (Danio rerio)
RHEA:70637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+)
RHEA:16804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] <=> adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]
GO:0043814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholactate guanylyltransferase activity
RHEA:18397	skos:prefLabel	"glutamate--tRNA(Gln) ligase"
RHEA:18397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate--tRNA(Gln) ligase"
RHEA:18397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L-glutamyl-tRNA(Glx)
RHEA:18397	skos:altLabel	"nondiscriminating glutamyl-tRNA synthetase"
REACT:R-RNO-5690759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Rattus norvegicus)
RHEA:42173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoyl-CoA + AH2 + O2 => (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O
RHEA:64299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH <=> (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)
REACT:R-HSA-9648949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A antagonists bind HTR3A pentamer (Homo sapiens)
REACT:R-SSC-2424243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Sus scrofa)
REACT:R-SSC-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Sus scrofa)
RHEA:14352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP
REACT:R-SSC-9679045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR9 dimer binds HCQ (Sus scrofa)
RHEA:53290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-L-gluconate + H(+) => 3-dehydro-scyllo-inosose + H2O
REACT:R-CFA-1655842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P hydrolyzes SREBP1A,1C,2 (Canis familiaris)
REACT:R-DME-3222259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF20 binds TP53 dimethylated on K370 and K382 (Drosophila melanogaster)
REACT:R-XTR-8932633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Xenopus tropicalis)
RHEA:72821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)
REACT:R-DDI-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Dictyostelium discoideum)
RHEA:70108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-5-carboxymethyl-tetronate + o-quinone methide => H(+) + penilactone D
RHEA:10258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O
REACT:R-BTA-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)
GO:0047437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxalocrotonate decarboxylase activity
GO:0047437	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-oxalocrotonate carboxy-lyase activity
GO:0047437	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)
REACT:R-HSA-9694528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Accessory proteins are recruited to the maturing virion (Homo sapiens)
REACT:R-HSA-391935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP1 receptor can bind PGD2 (Homo sapiens)
RHEA:16202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate => 4-aminobenzoate + H(+) + pyruvate
REACT:R-HSA-6811423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
RHEA:62095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate
RHEA:26536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoyl-CoA + AMP + diphosphate => 3-hydroxypropanoate + ATP + CoA
REACT:R-HSA-5655193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIAA0101 double monoubiquitination (Homo sapiens)
REACT:R-DME-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Drosophila melanogaster)
RHEA:49412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-1,2-colitosyltransferase"
RHEA:49412	skos:prefLabel	"alpha-1,2-colitosyltransferase"
RHEA:49412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose = alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)
REACT:R-XTR-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)
RHEA:30633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate
RHEA:68171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]
RHEA:45636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
REACT:R-MMU-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Mus musculus)
RHEA:33255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-7 + S-adenosyl-L-methionine = H(+) + menaquinol-7 + S-adenosyl-L-homocysteine
RHEA:37158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:11379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + NADP(+) <=> 4,21-dehydrogeissoschizine + NADPH
REACT:R-MMU-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Mus musculus)
REACT:R-DME-391934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP2 receptor can bind PGD2 (Drosophila melanogaster)
RHEA:71634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) + sulfate(out) <=> phosphate(out) + sulfate(in)
REACT:R-SCE-3371467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates HSF1 (Saccharomyces cerevisiae)
REACT:R-HSA-9008412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 phosphorylates RUNX2 (Homo sapiens)
GO:0061605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdopterin-synthase adenylyltransferase activity
RHEA:63398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + Fe(II)-hydroxyheme i => A + Fe(II)-heme i + H2O
REACT:R-BTA-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Bos taurus)
RHEA:51544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose = D-xylulose
GO:0046510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity
GO:0046510	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sulfolipid synthase
GO:0046510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity
RHEA:48925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine
REACT:R-MMU-416639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Mus musculus)
REACT:R-DRE-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Danio rerio)
RHEA:10100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sterol ester + H2O = a fatty acid + a sterol + H(+)
RHEA:10100	skos:altLabel	"cholesterol ester synthase"
RHEA:10100	skos:prefLabel	"sterol esterase"
RHEA:10100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cholesterol ester + H2O = a fatty acid + cholesterol + H(+)
RHEA:10100	skos:altLabel	"cholesterol esterase"
RHEA:10100	skos:altLabel	"triterpenol esterase"
RHEA:10100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sterol esterase"
RHEA:37058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate <=> 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate
REACT:R-BTA-8855564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Bos taurus)
RHEA:15499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine => 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate
RHEA:29461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(out) + H(+)(out) => beta-alanine(in) + H(+)(in)
RHEA:16573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate
RHEA:13023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + vanillate
RHEA:37189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate
GO:0103118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
GO:0103118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
GO:0103118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity
RHEA:66895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:61103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]
RHEA:34693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acryloyl-CoA + H2O => (R)-lactoyl-CoA
RHEA:72267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + formate(in) = chloride(in) + formate(out)
REACT:R-BTA-2396606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)
REACT:R-XTR-2430535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL phosphorylates ENSA (Xenopus tropicalis)
RHEA:32093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + erythromycin D + H(+) => 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine
REACT:R-SSC-191422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate-5-phosphate is further phosphorylated. (Sus scrofa)
REACT:R-DDI-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Dictyostelium discoideum)
REACT:R-BTA-6807106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN undergoes monoubiquitination (Bos taurus)
REACT:R-DME-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Drosophila melanogaster)
REACT:R-CFA-5654147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PLCG1 (Canis familiaris)
REACT:R-MMU-446198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Mus musculus)
REACT:R-RNO-351894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of BAP31 (Rattus norvegicus)
RHEA:66351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2
REACT:R-GGA-2581474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK1,4,7 phosphorylate MII to p-MII (Gallus gallus)
RHEA:28063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:65062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + taurochenodeoxycholate
RHEA:49876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5658231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs stimulate RAS GTPase activity (Canis familiaris)
REACT:R-DRE-202500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of IKK complex (Danio rerio)
REACT:R-MMU-419426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cannabinoid receptors can bind cannabinoids (Mus musculus)
REACT:R-DRE-159358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A3,4 dimers sulfate DA to DAOS (Danio rerio)
RHEA:26389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone
RHEA:26389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carotenoid-9',10'-cleaving dioxygenase"
RHEA:26389	skos:prefLabel	"carotenoid-9',10'-cleaving dioxygenase"
RHEA:26389	skos:altLabel	"beta-carotene 9',10'-monooxygenase"
REACT:R-RNO-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Rattus norvegicus)
GO:0003972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)
GO:0003972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA ligase (ATP) activity
GO:0003972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyribonucleotide ligase activity
GO:0003972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyribonucleotide synthase (ATP) activity
GO:0003972	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribonucleic ligase activity
RHEA:72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + secologanin <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin
REACT:R-BTA-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Bos taurus)
REACT:R-CEL-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Caenorhabditis elegans)
RHEA:22967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-ornithine <=> CO2 + putrescine
REACT:R-HSA-3928660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAM10 cleaves EFNAs (Homo sapiens)
REACT:R-RNO-2025724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Rattus norvegicus)
RHEA:16762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorohydroquinone + O2 => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)
REACT:R-DRE-5625870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Danio rerio)
REACT:R-MMU-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Mus musculus)
REACT:R-SSC-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Sus scrofa)
RHEA:68763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine
RHEA:35045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(4-aminobenzoyl)-L-glutamate(out) => N-(4-aminobenzoyl)-L-glutamate(in)
EC:3.2.1.198	skos:prefLabel	"alpha-mannan endo-1,2-alpha-mannanase"
EC:3.2.1.198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-mannan endo-1,2-alpha-mannanase"
RHEA:23344	skos:altLabel	"purine ribonucleosidase"
RHEA:23344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"purine nucleosidase"
RHEA:23344	skos:altLabel	"nucleosidase g"
RHEA:23344	skos:altLabel	"IAG-NH"
RHEA:23344	skos:altLabel	"inosine-adenosine-guanosine preferring nucleoside hydrolase"
RHEA:23344	skos:altLabel	"N-ribosyl purine ribohydrolase"
RHEA:23344	skos:prefLabel	"purine nucleosidase"
RHEA:23344	skos:altLabel	"ribonucleoside hydrolase"
RHEA:23344	skos:altLabel	"purine nucleoside hydrolase"
RHEA:23344	skos:altLabel	"purine beta-ribosidase"
RHEA:23344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a purine D-ribonucleoside + H2O = a purine nucleobase + D-ribose
RHEA:23344	skos:altLabel	"nucleosidase"
RHEA:23344	skos:altLabel	"nucleoside hydrolase"
RHEA:23344	skos:altLabel	"IAG-nucleoside hydrolase"
RHEA:23344	skos:altLabel	"N-D-ribosylpurine ribohydrolase"
RHEA:23344	skos:altLabel	"purine-specific nucleoside N-ribohydrolase"
REACT:R-HSA-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Homo sapiens)
REACT:R-DME-2395873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)
RHEA:12037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(imidazol-5-yl)lactate + NAD(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADH
RHEA:48913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1a => CMP + ganglioside GT1a + H(+)
REACT:R-MMU-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Mus musculus)
REACT:R-PFA-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Plasmodium falciparum)
REACT:R-GGA-169895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk's SH3 domain engages C3G (Gallus gallus)
REACT:R-HSA-389026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galanin receptors can bind galanin (Homo sapiens)
REACT:R-CFA-9603986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 chains to form LeA (Canis familiaris)
GO:0102818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lycopene cleavage oxygenase activity
REACT:R-CFA-193535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Canis familiaris)
REACT:R-XTR-5686685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Xenopus tropicalis)
REACT:R-GGA-202709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 dimerises (Gallus gallus)
REACT:R-CFA-975103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Canis familiaris)
REACT:R-GGA-444691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prokineticin receptors bind prokineticin (Gallus gallus)
REACT:R-MMU-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Mus musculus)
REACT:R-BTA-1678981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR9 processing at neutral pH (Bos taurus)
REACT:R-MMU-5357780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Mus musculus)
RHEA:39541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH
RHEA:15873	skos:altLabel	"GBSSI"
RHEA:15873	skos:altLabel	"NDPglucose-starch glucosyltransferase"
RHEA:15873	skos:altLabel	"waxy protein"
RHEA:15873	skos:altLabel	"GBSSII"
RHEA:15873	skos:altLabel	"starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase"
RHEA:15873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)
RHEA:15873	skos:altLabel	"starch synthase II"
RHEA:15873	skos:altLabel	"granule-bound starch synthase I"
RHEA:15873	skos:altLabel	"granule-bound starch synthase II"
RHEA:15873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NDP-glucose--starch glucosyltransferase"
RHEA:15873	skos:altLabel	"granule-bound starch synthase"
RHEA:15873	skos:altLabel	"GBSS"
RHEA:15873	skos:prefLabel	"NDP-glucose--starch glucosyltransferase"
RHEA:36667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine
REACT:R-BTA-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)
RHEA:11526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + H(+) + NADPH => 5beta-cholestan-3-one + NADP(+)
REACT:R-CFA-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Canis familiaris)
GO:0017046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polypeptide hormone binding
GO:0017046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide hormone binding
RHEA:46077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-eicosenoyl-CoA + H(+) + NADH => eicosanoyl-CoA + NAD(+)
RHEA:51284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate
REACT:R-BTA-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Bos taurus)
GO:0042166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine binding
RHEA:10257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate
REACT:R-GGA-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Gallus gallus)
REACT:R-SSC-1977958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with ERBB3 (Sus scrofa)
GO:0031712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B1 bradykinin receptor binding
GO:0031712	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	B1 bradykinin receptor ligand
REACT:R-RNO-110144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ADP <=> AMP + ATP [AK2] (Rattus norvegicus)
RHEA:14895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2,4-diaminopentanoate => D-ornithine
GO:0022878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose PTS transporter activity
GO:0022878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity
REACT:R-SSC-2028692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK4 (p-MST1) by caspase 3 (Sus scrofa)
REACT:R-MMU-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Mus musculus)
REACT:R-HSA-9656211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RHEA:16350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chlorate => A + chlorite + H2O
REACT:R-CEL-398185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG binds plexin B1 (Caenorhabditis elegans)
REACT:R-DRE-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Danio rerio)
REACT:R-BTA-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Bos taurus)
REACT:R-RNO-3301943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTK1 dimer transfers GS from GSH to CDNB (Rattus norvegicus)
RHEA:68867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isomaltose <=> alpha-D-glucose + D-glucose
RHEA:37650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-CFA-202702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD177 binds PECAM-1 (Canis familiaris)
REACT:R-SSC-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Sus scrofa)
REACT:R-DME-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)
RHEA:12056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"erythrose-4-phosphate dehydrogenase"
RHEA:12056	skos:altLabel	"erythrose 4-phosphate dehydrogenase"
RHEA:12056	skos:prefLabel	"erythrose-4-phosphate dehydrogenase"
RHEA:12056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + H2O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH
RHEA:12056	skos:altLabel	"E4PDH"
RHEA:12056	skos:altLabel	"E4P dehydrogenase"
GO:0035597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-isopentenyladenosine methylthiotransferase activity
GO:0035597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	i6A methylthiotransferase activity
REACT:R-BTA-5676940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Bos taurus)
REACT:R-MMU-8848658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Mus musculus)
REACT:R-RNO-5661114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Rattus norvegicus)
REACT:R-RNO-2990842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO2 (Rattus norvegicus)
REACT:R-DME-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)
REACT:R-XTR-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Xenopus tropicalis)
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribose transferase activity
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-N-deoxyribosylase activity
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-deoxyribosylase activity
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-N-glycosidase activity
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside trans-N-deoxyribosylase activity
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside deoxyribosyltransferase"
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)
GO:0050144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside deoxyribosyltransferase activity
GO:0050144	skos:prefLabel	"nucleoside deoxyribosyltransferase"
REACT:R-BTA-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Bos taurus)
RHEA:41518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase] => O2 + phylloquinone + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Bos taurus)
REACT:R-CFA-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Canis familiaris)
GO:0004551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleotide pyrophosphatase activity
GO:0004551	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dinucleotide nucleotidohydrolase activity
GO:0004551	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleotide diphosphatase activity
GO:0004551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dinucleotide phosphatase activity
GO:0050227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pteridine oxidase activity
GO:0050227	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)
RHEA:45589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + diphosphate
REACT:R-BTA-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
REACT:R-DME-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Drosophila melanogaster)
GO:0030626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U12 snRNA binding
REACT:R-SSC-5212679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3A binds Me2sR4-HIST1H4 (Sus scrofa)
GO:0047353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monomethylethanolamine phosphate cytidylyltransferase activity
GO:0047353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylphosphoethanolamine cytidylyltransferase activity
GO:0047353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:N-methylphosphoethanolamine cytidylyltransferase activity
GO:0047353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:N-methylethanolamine-phosphate cytidylyltransferase activity
GO:0047353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:P-MEA cytidylyltransferase activity
REACT:R-HSA-5211391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anthrax lef cleaves target cell MAP2K4 (MEK4) (Homo sapiens)
REACT:R-SCE-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Saccharomyces cerevisiae)
RHEA:38442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-XTR-9755304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUL1 ubiquitinates UBXN7 (Xenopus tropicalis)
RHEA:12425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate
REACT:R-MMU-6800198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Mus musculus)
GO:1990919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane-proteasome tether activity
GO:1990919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane-proteasome anchor activity
GO:1990919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nuclear membrane proteasome adaptor
GO:1990919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane proteasome tether activity
GO:1990919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane proteasome anchor
GO:1990919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteasome-nuclear membrane anchor activity
GO:1990919	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tethering factor for nuclear proteasome
GO:1990919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane proteasome tether
RHEA:54014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O
REACT:R-MMU-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Mus musculus)
GO:0050087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannitol:ferricytochrome-c 2-oxidoreductase activity
GO:0050087	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyol dehydrogenase activity
GO:0050087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannitol dehydrogenase (cytochrome) activity
GO:0031873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 proteinase activated receptor binding
GO:0031873	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 proteinase activated receptor ligand
RHEA:60160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + vincristine(in) = ADP + H(+) + phosphate + vincristine(out)
REACT:R-HSA-8848713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds BCAR1 (Homo sapiens)
REACT:R-HSA-167047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-beta-NGF dimerizes (Homo sapiens)
REACT:R-GGA-8855237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Gallus gallus)
REACT:R-MMU-8937442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES3 hydrolyses CHEST to CHOL and LCFA(-) (Mus musculus)
REACT:R-MMU-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Mus musculus)
REACT:R-CFA-751019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:G12/13 complex dissociates (Canis familiaris)
REACT:R-CEL-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Caenorhabditis elegans)
RHEA:63849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 => 2 3',4'-dihydroxyaurone + 2 H2O
RHEA:48030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + diacetylglycerol + H(+) => H2O + triacetin
REACT:R-GGA-8944232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XII (Gallus gallus)
REACT:R-BTA-4641147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DACT1 binds DVL2 (Bos taurus)
REACT:R-CFA-8855711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Canis familiaris)
REACT:R-DME-209055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)
RHEA:64750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate => H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine
GO:0005249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-sensitive potassium channel
GO:0005249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium ion channel activity
GO:0005249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage gated potassium channel activity
GO:0005249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of voltage gated Potassium channels (Homo sapiens)
GO:0005249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent potassium channel activity
GO:0005249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity
RHEA:13434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine + H(+) + H2O => 2'-deoxyuridine + NH4(+)
REACT:R-GGA-164617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of Extended Telomeric Chromosome End (Gallus gallus)
REACT:R-DRE-186798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binds to PDGF-beta receptors only (Danio rerio)
REACT:R-XTR-8940998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36RN, IL1F10 bind IL1RL2 (Xenopus tropicalis)
REACT:R-SCE-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Saccharomyces cerevisiae)
RHEA:63470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + all-trans-octaprenyl phosphate + H(+) => all-trans-octaprenol + ATP
RHEA:38431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)
REACT:R-MMU-8851988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN2A2 binds T cell surface (Mus musculus)
RHEA:22640	skos:prefLabel	"3-dehydrosphinganine reductase"
RHEA:22640	skos:altLabel	"KTS reductase"
RHEA:22640	skos:altLabel	"DSR"
RHEA:22640	skos:altLabel	"3-oxosphinganine reductase"
RHEA:22640	skos:altLabel	"D-3-oxosphinganine reductase"
RHEA:22640	skos:altLabel	"3-ketosphinganine reductase"
RHEA:22640	skos:altLabel	"D-3-oxosphinganine:B-NADPH oxidoreductase"
RHEA:22640	skos:altLabel	"D-3-dehydrosphinganine reductase"
RHEA:22640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydrosphinganine reductase"
RHEA:22640	skos:altLabel	"3-oxosphinganine:NADPH oxidoreductase"
RHEA:22640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH
RHEA:52394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + ADP + H(+) => ATP + D-erythronate
RHEA:11376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geissoschizine dehydrogenase"
RHEA:11376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + NADPH
RHEA:11376	skos:prefLabel	"geissoschizine dehydrogenase"
REACT:R-RNO-389487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 2 receptor can bind orexin-B neuropeptide (Rattus norvegicus)
RHEA:20877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-XTR-9645524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose binds TIFA (Xenopus tropicalis)
RHEA:39090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanedioyl-CoA + O2 <=> (2E)-decenedioyl-CoA + H2O2
RHEA:15251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-galloyl-beta-D-glucose + UDP => 3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose
RHEA:72384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + urate(in) => Na(+)(in) + urate(out)
REACT:R-GGA-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Gallus gallus)
RHEA:69091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + H2O + NAD(+) <=> butanoate + 2 H(+) + NADH
REACT:R-GGA-2129362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin microfibril assembly (Gallus gallus)
REACT:R-CEL-5696914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP28 deubiquitinates CLSPN and MYC (Caenorhabditis elegans)
REACT:R-GGA-158333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Gallus gallus)
RHEA:44707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0005176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HER2 receptor binding
GO:0005176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ErbB-2 class receptor binding
GO:0005176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu receptor binding
GO:0005176	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ErbB-2 class receptor ligand
GO:0005176	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Neu receptor ligand
GO:0005176	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	HER2 receptor ligand
REACT:R-CEL-170044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Caenorhabditis elegans)
REACT:R-HSA-8875431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRIG1 undergoes ubiquitination (Homo sapiens)
RHEA:13321	skos:prefLabel	"dimethylmalate dehydrogenase"
RHEA:13321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylmalate dehydrogenase"
RHEA:13321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO2 + NADH
RHEA:46540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0017098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphonylurea receptor binding
GO:0017098	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sulfonylurea receptor ligand
GO:0017098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfonylurea receptor binding
REACT:R-CFA-74718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalisation of the insulin receptor (Canis familiaris)
REACT:R-DRE-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Danio rerio)
REACT:R-DDI-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)
RHEA:23695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-malate <=> H2O + maleate
RHEA:45818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + pyruvate => (S)-lactate + A
RHEA:10141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin D2
RHEA:12541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanine + tRNA(Ala) => AMP + diphosphate + L-alanyl-tRNA(Ala)
REACT:R-CEL-159101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Caenorhabditis elegans)
REACT:R-HSA-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Homo sapiens)
RHEA:23349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2
RHEA:48618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + leukotriene E4 => H2O + leukotriene D4
RHEA:15075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + N(2),6-disulfo-D-glucosamine => 3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O
REACT:R-XTR-9691215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFR2 dimer (Xenopus tropicalis)
RHEA:50251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + diphosphate
REACT:R-CEL-193369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Caenorhabditis elegans)
REACT:R-CFA-1169402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of E2 conjugating enzymes (Canis familiaris)
RHEA:64486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA => acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA
REACT:R-MMU-193691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kB migrates to the nucleus and turns on transcription (Mus musculus)
REACT:R-CFA-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Canis familiaris)
RHEA:36087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine
REACT:R-DRE-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Danio rerio)
RHEA:41790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + CoA => acetyl-CoA + holo-[ACP]
RHEA:23066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + FMN + 2 H(+) + H2O + sulfite => an alkanesulfonate + FMNH2 + O2
GO:0102340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-behenoyl-CoA reductase activity
RHEA:29749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate(out) => 3-phenylpropanoate(in)
RHEA:69732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + phenylacetyl-AMP => AMP + H(+) + phenylacetyl-CoA
RHEA:28384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + L-lysine => H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine
REACT:R-HSA-168896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of NS1 to PKR (Homo sapiens)
REACT:R-SSC-5651773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds POLB at long-patch BER site (Sus scrofa)
REACT:R-HSA-9604553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEY2 gene expression is stimulated by NOTCH4 (Homo sapiens)
GO:0018786	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-haloalkane halidohydrolase activity
GO:0018786	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-haloalkane dehalogenase activity
GO:0018786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	haloalkane dehalogenase activity
GO:0018786	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-chlorohexane halidohydrolase activity
GO:0031957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-long-chain fatty acid-CoA ligase activity
GO:0031957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Homo sapiens)
GO:0031957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-long-chain-fatty-acid-CoA ligase activity
GO:0031957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very long-chain fatty acid-CoA ligase activity
GO:0031957	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	very-long-chain fatty acid activation
REACT:R-SSC-2424252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds collagen, fibronectin, aggrecan and matrilins (Sus scrofa)
REACT:R-DDI-4570485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO3 (Dictyostelium discoideum)
REACT:R-GGA-879575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Gallus gallus)
REACT:R-BTA-5696482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTF1 binds LIFR:JAKs (Bos taurus)
REACT:R-SSC-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Sus scrofa)
RHEA:64314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrogeodin + 2 FAD + H(+) + 4 H2O => 2 chloride + 2 FADH2 + 2 O2 + sulochrin
REACT:R-MMU-111238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR2  homodimer (Mus musculus)
RHEA:49181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide d + S-adenosyl-L-methionine => a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine
RHEA:42151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine
GO:0034917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhex-2-enoyl-CoA hydratase activity
RHEA:53081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-RNO-5625426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde IFT (Rattus norvegicus)
REACT:R-SSC-2731074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Sus scrofa)
RHEA:35500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:54755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) <=> dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)
RHEA:54847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexan-3-one + NADPH + O2 <=> ethyl butanoate + H2O + NADP(+)
GO:0008720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lactic dehydrogenase activity
GO:0008720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-lactic acid dehydrogenase activity
GO:0008720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lactate dehydrogenase activity
GO:0015513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity secondary active nitrite transmembrane transporter activity
GO:0015513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite uptake permease activity
REACT:R-HSA-9021949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEF2C gene expression is inhibited by MECP2 (Homo sapiens)
REACT:R-CFA-6786124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)
GO:0003678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent DNA helicase activity
GO:0003678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA helicase activity
GO:0003678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop dissociation and strand annealing (Homo sapiens)
RHEA:38190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0098851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded miRNA binding
GO:0098851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miRNA duplex binding
RHEA:62573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine => glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine
REACT:R-SSC-83582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Sus scrofa)
REACT:R-XTR-376200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A10-mediated uptake of small neutral amino acids (Xenopus tropicalis)
REACT:R-XTR-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Xenopus tropicalis)
RHEA:27744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-alpha-D-ribose 1-phosphate + adenine => 2'-deoxyadenosine + phosphate
REACT:R-XTR-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Xenopus tropicalis)
RHEA:62748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lovastatin = (S)-2-methylbutanoate + H(+) + monacolin J
REACT:R-DRE-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Danio rerio)
GO:0034845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthyl-2-methyl-succinyl-CoA dehydrogenase activity
REACT:R-DRE-390438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR2 reduces PalmCoA to HXOL (Danio rerio)
REACT:R-RNO-9638064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Rattus norvegicus)
REACT:R-DME-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-XTR-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Xenopus tropicalis)
REACT:R-CFA-450187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated within the TAK1 complex (Canis familiaris)
REACT:R-XTR-1602398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Xenopus tropicalis)
EC:3.9.1.3	skos:altLabel	"PHP"
EC:3.9.1.3	skos:prefLabel	"phosphohistidine phosphatase"
EC:3.9.1.3	skos:altLabel	"protein histidine phosphatase"
EC:3.9.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphohistidine phosphatase"
GO:0046508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on carbon-sulfur bonds"
GO:0046508	skos:prefLabel	"Acting on carbon-sulfur bonds"
GO:0046508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on carbon-sulfur bonds
GO:0046508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on carbon-sulphur bonds
RHEA:48186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:65487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + hexanoyl-CoA <=> CoA + hexyl hexanoate
RHEA:23577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:49874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (+)-dehydrodiconiferyl acid ketone + a quinone + H2O
RHEA:14916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + thymidine <=> adenosine + dTMP
REACT:R-HSA-204863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang2 (Homo sapiens)
RHEA:24023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(N(omega)-L-arginino)succinate <=> fumarate + L-arginine
RHEA:11883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2
REACT:R-RNO-1655851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S2P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)
REACT:R-SSC-1296024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in neuroendocrine cells (Sus scrofa)
RHEA:69813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:68701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
RHEA:32718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-methylmalate + NAD(+) <=> 2-oxobutanoate + CO2 + NADH
REACT:R-HSA-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Homo sapiens)
REACT:R-BTA-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Bos taurus)
REACT:R-MMU-9714483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the ER membrane (Mus musculus)
REACT:R-HSA-9683719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike protein forms a homotrimer (Homo sapiens)
GO:0016648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor
GO:0016648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor
GO:0016648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a disulfide as acceptor"
GO:0016648	skos:prefLabel	"With a disulfide as acceptor"
RHEA:17731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cholesterol ester + CoA => an acyl-CoA + cholesterol
REACT:R-DME-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)
REACT:R-MMU-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Mus musculus)
RHEA:37449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + tetracenomycin D3 => O2 + tetracenomycin F1
RHEA:54437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate
GO:1990313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type-III cohesin domain binding
GO:0033207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,4-GalNAc transferase activity
GO:0033207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,4-N-acetylgalactosaminyltransferase activity
RHEA:16244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an NDP-alpha-D-glucose + D-fructose <=> a ribonucleoside 5'-diphosphate + H(+) + sucrose
REACT:R-HSA-159179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)
REACT:R-HSA-193808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)
REACT:R-RNO-9749590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates ALB (Rattus norvegicus)
RHEA:22291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose
REACT:R-BTA-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)
RHEA:51344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
RHEA:67571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + taurochenodeoxycholate <=> adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate
RHEA:18890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + UDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + UDP
RHEA:38000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine => H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine
REACT:R-PFA-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Plasmodium falciparum)
RHEA:46862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate
RHEA:48933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1b => CMP + ganglioside GQ1b + H(+)
RHEA:39389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA
REACT:R-RNO-174120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Rattus norvegicus)
REACT:R-HSA-165708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)
REACT:R-HSA-6802915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Moderate kinase activity BRAF mutants bind RAS:GTP (Homo sapiens)
REACT:R-CFA-5635102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 is internalized (Canis familiaris)
GO:0103090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiohexylmalate dehydrogenase activity
EC:3.1.6.-	skos:prefLabel	"Sulfuric ester hydrolases"
EC:3.1.6.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Sulfuric ester hydrolases"
GO:0001601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide YY receptor activity
REACT:R-GGA-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Gallus gallus)
REACT:R-XTR-5649801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)
REACT:R-DME-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Drosophila melanogaster)
REACT:R-XTR-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Xenopus tropicalis)
RHEA:32137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => 2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-3341343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
REACT:R-CFA-1889955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT dimers transfer GlcA to tetrasaccharide linker (Canis familiaris)
GO:0019782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISG15 activating enzyme activity
GO:0019782	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UBE1L
RHEA:29859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine
RHEA:62357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GDP + H2O => 8-oxo-GMP + H(+) + phosphate
RHEA:64079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)
REACT:R-CFA-2730876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IKK-beta by TAK1 (Canis familiaris)
REACT:R-HSA-9609741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2D (GRIN2D) (Homo sapiens)
GO:0050441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)
GO:0050441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ethyl-3-hydroxybutanedioate synthase activity
GO:0050441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ethylmalate synthase activity
GO:0050441	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity
RHEA:64578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome b5] + NADPH
RHEA:43648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + CoA
REACT:R-DRE-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Danio rerio)
REACT:R-GGA-446634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 is activated by autophosphorylation (Gallus gallus)
REACT:R-BTA-3465459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Bos taurus)
REACT:R-GGA-190682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin synthesis (generic) (Gallus gallus)
RHEA:52938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP] => 3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O
RHEA:41423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 <=> CO2 + grixazone B + 4 H2O
REACT:R-SPO-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Schizosaccharomyces pombe)
RHEA:16326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phospho-alpha-D-glucuronate + H(+) + UTP => diphosphate + UDP-alpha-D-glucuronate
REACT:R-HSA-9665416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)
REACT:R-SSC-5654729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Sus scrofa)
RHEA:47691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-hydroxy-L-proline + NADP(+) <=> Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH
REACT:R-DRE-70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate + H2O => 4-imidazolone-5-propionate (Danio rerio)
RHEA:62412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H2O = acetyl-CoA + vanillin
RHEA:15125	skos:prefLabel	"heparan-alpha-glucosaminide N-acetyltransferase"
RHEA:15125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) = CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)
RHEA:15125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heparan-alpha-glucosaminide N-acetyltransferase"
RHEA:17931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + an N-acylsphing-4-enine 1-phosphate + H(+) => an N-acylsphing-4-enine + ATP
REACT:R-BTA-200423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Bos taurus)
RHEA:66478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenate 28-beta-D-glucoside + UDP => gypsogenate + UDP-alpha-D-glucose
REACT:R-HSA-442345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hZIP10 mediates zinc influx into cells (Homo sapiens)
RHEA:43091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine <=> 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine
RHEA:50224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-450595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR:mRNA complex translocates from the nucleus to the cytosol (Rattus norvegicus)
REACT:R-XTR-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Xenopus tropicalis)
RHEA:35785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + kanamycin B + UDP => neamine + UDP-alpha-D-kanosamine
RHEA:70265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate
RHEA:21343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 <=> 2 vanillin
REACT:R-GGA-5218841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)
GO:0008111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacyl-CoA racemase activity
GO:0008111	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methylacyl-CoA 2-epimerase activity
RHEA:35852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-RNO-2213239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MHC II alpha beta heterodimer (Rattus norvegicus)
RHEA:12343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] <=> H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)
REACT:R-CFA-3640862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase binds AXIN (Canis familiaris)
RHEA:33800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidinol + NAD(+) => H(+) + L-histidinal + NADH
REACT:R-RNO-8957265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades TP73 polyubiquitinated by ITCH (Rattus norvegicus)
GO:0010242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxygen evolving activity
GO:0010242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	photosynthetic water oxidation
EC:3.4.14.11	skos:altLabel	"X-prolyl dipeptidyl aminopeptidase"
EC:3.4.14.11	skos:prefLabel	"Xaa-Pro dipeptidyl-peptidase"
EC:3.4.14.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Xaa-Pro dipeptidyl-peptidase"
EC:3.4.14.11	skos:altLabel	"X-Pro dipeptidyl-peptidase"
REACT:R-DME-209220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liberation of CI from SU(FU) repression (Drosophila melanogaster)
GO:0008656	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	caspase activator activity
GO:0008656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type endopeptidase activator activity involved in apoptotic process
RHEA:40152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
RHEA:49375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protodeoxyviolaceinate <=> H2O + NAD(+) + protoviolaceinate
RHEA:19238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxymethyl-4-methylbut-2-en-1,4-olide => 4-carboxymethyl-3-methylbut-2-en-1,4-olide
REACT:R-HSA-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Homo sapiens)
RHEA:40288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + decanedioate => AMP + decanedioyl-CoA + diphosphate
REACT:R-BTA-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Bos taurus)
REACT:R-PFA-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)
REACT:R-XTR-2197588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD2 binds RBPJ and MAML in the nucleus (Xenopus tropicalis)
REACT:R-GGA-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Gallus gallus)
REACT:R-GGA-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Gallus gallus)
RHEA:53247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Danio rerio)
REACT:R-HSA-9729283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein is methylated by PRMT1 (Homo sapiens)
RHEA:53938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2
RHEA:15111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH => 2-dehydro-3-deoxy-D-gluconate + NADP(+)
REACT:R-RNO-77585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Rattus norvegicus)
REACT:R-HSA-9021596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane estrogen receptors bind SRC (Homo sapiens)
REACT:R-XTR-205286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS interacts with p-KIT (Xenopus tropicalis)
REACT:R-HSA-606289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	New CENPA-containing nucleosomes are deposited at the centromere (Homo sapiens)
REACT:R-XTR-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)
RHEA:47109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + taurine => H2O + taurocholate
RHEA:27507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cocaine + H2O => benzoate + ecgonine methyl ester + H(+)
REACT:R-HSA-6809320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Homo sapiens)
EC:2.4.1.227	skos:prefLabel	"undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase"
EC:2.4.1.227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase"
EC:2.4.1.227	skos:altLabel	"undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase"
EC:2.4.1.227	skos:altLabel	"MurG transferase"
EC:2.4.1.227	skos:altLabel	"UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase"
REACT:R-SSC-5675470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC2/3 (cIAP1/2) is autoubiquitinated (Sus scrofa)
REACT:R-DDI-1614461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetramerization of procollagen VI (Dictyostelium discoideum)
REACT:R-RNO-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Rattus norvegicus)
REACT:R-RNO-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Rattus norvegicus)
REACT:R-BTA-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)
RHEA:31300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + perillyl aldehyde => 2 H(+) + NADH + perillate
REACT:R-DDI-5690023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL binds 4Fe-4S (Dictyostelium discoideum)
RHEA:35870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA
RHEA:51161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)
REACT:R-MMU-195378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of VEGF proteins (Mus musculus)
RHEA:41104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)
REACT:R-GGA-442862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of  p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)
REACT:R-HSA-1592249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)
REACT:R-MMU-3900194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates DDX5 with SUMO2 (Mus musculus)
REACT:R-PFA-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)
RHEA:32865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol
REACT:R-DME-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Drosophila melanogaster)
RHEA:50729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(4-hydroxyphenyl)acetaldehyde oxime => 4-hydroxyphenylacetonitrile + H2O
REACT:R-HSA-2730752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)
REACT:R-DDI-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Dictyostelium discoideum)
RHEA:27340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] <=> 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]
GO:0090489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)
GO:0090489	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tryptophan N-monooxygenase activity
RHEA:10021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH
RHEA:65383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:66796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:32176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)
RHEA:18362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl D-xylosyl phosphate + L-seryl-[protein] => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)
REACT:R-HSA-5655248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
RHEA:54734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
REACT:R-RNO-177926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of PAG by SHP2 (Rattus norvegicus)
RHEA:38647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)
REACT:R-BTA-8964317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Bos taurus)
RHEA:29047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+)(in) + H2 = a menaquinol + 2 H(+)(out)
REACT:R-RNO-5691150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFR2 dimer binds 2xholoTF (Rattus norvegicus)
REACT:R-DRE-202710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MERTK receptor binds ligands (Gas6 or Protein S) (Danio rerio)
RHEA:63581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxyecdysone 22-phosphate + H2O => 20-hydroxyecdysone + phosphate
RHEA:58105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
RHEA:27632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolaldehyde + H(+) + NADH => ethylene glycol + NAD(+)
RHEA:12028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxymethylhydantoinase"
RHEA:12028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-5-carboxymethylhydantoin = H(+) + N-carbamoyl-L-aspartate
RHEA:12028	skos:prefLabel	"carboxymethylhydantoinase"
RHEA:52070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-hexadecenoyloxy)-octadecanoate + H2O
REACT:R-DME-2029475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of AA by iPLA2 upon FCGR activation (Drosophila melanogaster)
REACT:R-MMU-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Mus musculus)
REACT:R-XTR-8870346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Xenopus tropicalis)
REACT:R-MMU-3240957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PRC2-EZH2 complex (Mus musculus)
REACT:R-BTA-5654406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Bos taurus)
REACT:R-XTR-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Xenopus tropicalis)
RHEA:24875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine + phosphate => H2O + O-phospho-D-serine
REACT:R-HSA-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-DDI-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Dictyostelium discoideum)
REACT:R-CFA-388468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP(20-28) binds AVPR1A,B (Canis familiaris)
REACT:R-HSA-9694541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)
GO:0102497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inositol dehydrogenase (NADP+) activity
REACT:R-MMU-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
REACT:R-HSA-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Homo sapiens)
RHEA:48581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate, water dikinase]-phosphate + H(+) + phosphate => [pyruvate, water dikinase] + diphosphate
REACT:R-HSA-168299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribonucleoprotein release from M1 proteins (Homo sapiens)
GO:0102588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside 6''-O-malonyltransferase activity
REACT:R-HSA-5159250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF7IP binds SETDB1 (Homo sapiens)
REACT:R-DRE-2855047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of internal thioester in C4b (Danio rerio)
RHEA:63716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	losartan + UDP-alpha-D-glucuronate = losartan-1-N-beta-D-glucuronide + UDP
REACT:R-SSC-9728664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1R agonists (Sus scrofa)
REACT:R-HSA-9725117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK gene expression (Homo sapiens)
RHEA:42831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:33684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine + octadecanoyl-CoA => 3-oxoeicosasphinganine + CO2 + CoA
REACT:R-DRE-1678694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Danio rerio)
REACT:R-SCE-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)
RHEA:42231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + A <=> AH2 + estrone
REACT:R-XTR-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Xenopus tropicalis)
RHEA:68877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + piperonylate => AMP + diphosphate + NADP(+) + piperonal
REACT:R-GGA-74737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)
RHEA:15062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a Fe(II)-siderophore + H(+) + NAD(+) => 2 a Fe(III)-siderophore + NADH
RHEA:55493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:25530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O
RHEA:21809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopiperazine + H2O => glycylglycine
RHEA:11099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH
RHEA:49370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+)
REACT:R-DME-5634100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 dissociates from RXRA:PPARD:atRA (Drosophila melanogaster)
REACT:R-BTA-2130640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of clathrin coated vesicle by Ii (Bos taurus)
REACT:R-RNO-8871366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Rattus norvegicus)
REACT:R-DME-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Drosophila melanogaster)
RHEA:63729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	candesartan + UDP-alpha-D-glucuronate => candesartan-2-N-beta-D-glucuronide + UDP
RHEA:60864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-2129353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin associates with microfibrils (Mus musculus)
RHEA:51939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(glutathione-S-yl)-hydroquinone + glutathione <=> glutathione disulfide + hydroquinone
RHEA:61057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]
RHEA:49898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine-1,6-dicarboxylate => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate
RHEA:51395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + serotonin <=> CoA + H(+) + N-(9Z-octadecenoyl)-serotonin
REACT:R-CFA-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Canis familiaris)
RHEA:35346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydocosanoyl-CoA + NADP(+) <=> 3-oxodocosanoyl-CoA + H(+) + NADPH
RHEA:32468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + sarcosine => glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:65909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + pyruvate => H2O + L-alanine + xanthurenate
GO:0034003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pemnaspirodiene synthase activity
GO:0034003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HVS
GO:0034003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vetispiradiene cyclase activity
GO:0034003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vetispiradiene synthase activity
GO:0034003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity
GO:0034003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vetispiradiene-forming farnesyl pyrophosphate cyclase activity
GO:0052670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geraniol phosphotransferase activity
GO:0052670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geraniol kinase activity
RHEA:54011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
RHEA:48446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol
RHEA:65378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine
REACT:R-HSA-8936628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
REACT:R-CEL-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Caenorhabditis elegans)
RHEA:68446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal => 5-cis-lycopene + O2
RHEA:62107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:58107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-MMU-204813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb14 (Mus musculus)
REACT:R-DRE-4084984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Danio rerio)
REACT:R-DRE-5649873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Danio rerio)
REACT:R-DDI-936986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)
RHEA:42861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctanoyl-sn-glycerol + phosphate
GO:0062050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-mannose ethanolamine phosphate phosphodiesterase activity
RHEA:62313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylate + UDP-alpha-D-glucose => H(+) + salicylate 2-O-beta-D-glucoside + UDP
REACT:R-SSC-2130725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of MHC II:Ii clathrin coated vesicle (Sus scrofa)
RHEA:35702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-versiconol + NADP(+) <=> (2S-3S)-versiconal hemiacetal + H(+) + NADPH
RHEA:65754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-glutamate + CO2 + succinate => 2-oxoglutarate + L-glutamate + O2
REACT:R-CEL-177943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to EGF:EGFR complex (Caenorhabditis elegans)
GO:0047070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxyethylcatechol 2,3-dioxygenase activity
GO:0047070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxy-beta-phenylpropionate oxygenase activity
GO:0047070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)
GO:0047070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxy-beta-phenylpropionic dioxygenase activity
GO:0047070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity
REACT:R-XTR-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Xenopus tropicalis)
RHEA:70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-dodecanoyl-3-oxosphinganine => 3-oxosphinganine + dodecanoyl-CoA
RHEA:32674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UDP-N-acetyl-alpha-D-glucosamine <=> ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate
REACT:R-SCE-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Saccharomyces cerevisiae)
REACT:R-DME-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Drosophila melanogaster)
REACT:R-XTR-158784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Xenopus tropicalis)
RHEA:58941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH => all-trans-lycopaoctaene + diphosphate + NAD(+)
RHEA:53817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-succinyl-L-serine => L-cysteine + succinate
REACT:R-GGA-399712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Gallus gallus)
REACT:R-CFA-2028651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Canis familiaris)
GO:0102274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione S-conjugate carboxypeptidase activity
REACT:R-SSC-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Sus scrofa)
REACT:R-RNO-9647631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds PIPs (Rattus norvegicus)
RHEA:67746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O
GO:0003984	skos:altLabel	"alpha-acetohydroxyacid synthase"
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-acetolactate synthetase activity
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-acetohydroxy acid synthetase activity
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-acetohydroxyacid synthase activity
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetolactate pyruvate-lyase (carboxylating) activity
GO:0003984	skos:altLabel	"alpha-acetolactate synthetase"
GO:0003984	skos:altLabel	"alpha-acetohydroxy acid synthetase"
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-acetolactate synthase activity
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetohydroxy acid synthetase activity
GO:0003984	skos:altLabel	"acetohydroxyacid synthase"
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetolactic synthetase activity
GO:0003984	skos:altLabel	"alpha-acetolactate synthase"
GO:0003984	skos:altLabel	"acetohydroxy acid synthetase"
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetolactate synthase"
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:pyruvate acetaldehydetransferase (decarboxylating)
GO:0003984	skos:altLabel	"acetolactic synthetase"
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetohydroxyacid synthase activity
GO:0003984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetolactate synthase activity
GO:0003984	skos:prefLabel	"acetolactate synthase"
GO:0003984	skos:altLabel	"acetolactate pyruvate-lyase (carboxylating)"
REACT:R-BTA-2142859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growing HA is extruded from the cell by ABCC5 (Bos taurus)
RHEA:47489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isodeoxycholate + NADP(+)
REACT:R-MMU-1236965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Export of peptide loaded MHC class I complex to PM (Mus musculus)
REACT:R-SCE-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Saccharomyces cerevisiae)
REACT:R-HSA-77319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Homo sapiens)
REACT:R-GGA-2022405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)
REACT:R-SPO-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Schizosaccharomyces pombe)
REACT:R-DRE-450222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Danio rerio)
REACT:R-SSC-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Sus scrofa)
REACT:R-DRE-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Danio rerio)
GO:0018665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate 1-monooxygenase activity
GO:0018665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylacetic 1-hydroxylase activity
GO:0018665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenyl-acetate 1-hydroxylase activity
GO:0018665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylacetate 1-hydroxylase activity
GO:0018665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)
GO:0018665	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-HPA 1-hydroxylase activity
REACT:R-HSA-2024084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS-GAGs translocate to the lysosome for degradation (Homo sapiens)
REACT:R-MMU-373716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacting NCK-1 (Mus musculus)
REACT:R-SSC-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Sus scrofa)
REACT:R-HSA-879222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP:NLRP1 binds ATP (Homo sapiens)
GO:0051266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sirohydrochlorin ferrochelatase activity
GO:0051266	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	siroheme synthase activity
GO:0051266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sirohydrochlorin ferro-lyase activity
GO:0051266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	siroheme ferro-lyase (sirohydrochlorin-forming)
REACT:R-CFA-8931858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Canis familiaris)
REACT:R-MMU-975389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Mus musculus)
RHEA:21118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 1-phosphate + D-glucose => D-maltose + phosphate
RHEA:56435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate
REACT:R-HSA-9712204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region (Homo sapiens)
RHEA:23431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-BTA-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Bos taurus)
GO:0034555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-dibromobisphenol A reductive dehalogenase activity
RHEA:69363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + H(+) + H2O2 + L-tyrosyl-[protein] <=> 3-bromo-L-tyrosyl-[protein] + 2 H2O
REACT:R-HSA-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Homo sapiens)
RHEA:62494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-arginyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-arginine
REACT:R-HSA-5687120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Homo sapiens)
GO:0001019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plastid promoter transcription regulatory region sequence-specific DNA binding
RHEA:19448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxyindole + O2 <=> anthranilate + CO2 + H(+)
REACT:R-DRE-9632033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GalNAc to chondroitin (Danio rerio)
REACT:R-MMU-912685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBP43 binds IFNAR2 and prevents JAK1 interaction (Mus musculus)
REACT:R-BTA-6800434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule lumen proteins (Bos taurus)
REACT:R-DRE-4085994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TOPORS SUMOylates SIN3A with SUMO1 (Danio rerio)
RHEA:53971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[BtrI ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]
REACT:R-CFA-8854738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:CSFR binds CSFR (Canis familiaris)
REACT:R-CEL-198824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Caenorhabditis elegans)
RHEA:25195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylcatechol + H(+) + NADH => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)
RHEA:38598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)
REACT:R-RNO-9677917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA inhibitors bind MAOA:FAD (Rattus norvegicus)
REACT:R-DRE-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Danio rerio)
REACT:R-BTA-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Bos taurus)
EC:7.2.2.16	skos:altLabel	"iron(III) hydroxamate ABC transporter"
EC:7.2.2.16	skos:prefLabel	"ABC-type ferric hydroxamate transporter"
EC:7.2.2.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type ferric hydroxamate transporter"
EC:7.2.2.16	skos:altLabel	"iron(III) hydroxamate transporting ATPase"
REACT:R-XTR-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Xenopus tropicalis)
REACT:R-HSA-428536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP39 (Vilse) binds ROBO1:SLIT2 (Homo sapiens)
REACT:R-CFA-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Canis familiaris)
REACT:R-BTA-9633044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR binds STRN (Bos taurus)
REACT:R-SSC-141200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB:FAD oxidatively deaminates of PEA (Sus scrofa)
REACT:R-GGA-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Gallus gallus)
RHEA:52900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide = 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate
RHEA:52900	skos:prefLabel	"Ni-sirohydrochlorin a,c-diamide reductive cyclase"
RHEA:52900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Ni-sirohydrochlorin a,c-diamide reductive cyclase"
REACT:R-XTR-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Xenopus tropicalis)
REACT:R-RNO-209566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is auto-ubiquitinated (Rattus norvegicus)
REACT:R-HSA-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)
RHEA:29067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) + menaquinone-8 = CO2 + menaquinol-8
REACT:R-HSA-975160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
REACT:R-RNO-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Rattus norvegicus)
REACT:R-CFA-622415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 binds NEMO (Canis familiaris)
RHEA:18243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,5S)-2,5-diaminohexanoate => D-lysine
REACT:R-DDI-5618331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC6 deacetylates microtubules (Dictyostelium discoideum)
REACT:R-BTA-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)
GO:0120227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-CoA binding
GO:0120227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-coenzyme A binding
GO:0120227	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acyl binding
REACT:R-DRE-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Danio rerio)
GO:0015115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	silicate transmembrane transporter activity
RHEA:35065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + pyrazine-2-carboxylate => H2O + pyrazinamide
RHEA:44070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O
REACT:R-GGA-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Gallus gallus)
RHEA:26530	skos:prefLabel	"4-hydroxybutanoyl-CoA dehydratase"
RHEA:26530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybutanoyl-CoA dehydratase"
RHEA:26530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O
GO:1990600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded DNA endodeoxyribonuclease activator activity
REACT:R-MMU-199203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK1/3/4 phosphorylate PanK (Mus musculus)
RHEA:43899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-8876696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT1,2 transfer acyl group to CHOL forming CHEST (Bos taurus)
RHEA:45528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
REACT:R-HSA-9692539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds HRH1 inverse agonists (Homo sapiens)
RHEA:52409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH
REACT:R-CFA-5654565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Canis familiaris)
RHEA:57979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside C-K + H(+) + UDP
GO:0016715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0016715	skos:prefLabel	"With reduced ascorbate as one donor, and incorporation of one atom of oxygen"
GO:0016715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With reduced ascorbate as one donor, and incorporation of one atom of oxygen"
RHEA:46282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
GO:0080070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity
REACT:R-HSA-5649725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Homo sapiens)
REACT:R-SSC-8942607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Sus scrofa)
REACT:R-HSA-2002460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB binds Collagen chains (Homo sapiens)
RHEA:35891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
GO:0102327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-CoA hydrolase activity
RHEA:61372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate
REACT:R-SSC-9663492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL dissociates from GSTA1, FABP1 (Sus scrofa)
GO:0103044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosomal protein S6 glutamate-glutamate ligase activity
GO:0047072	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoate 2,3-oxygenase activity
GO:0047072	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)
GO:0047072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate 2,3-dioxygenase activity
REACT:R-DME-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Drosophila melanogaster)
REACT:R-BTA-1605768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Bos taurus)
RHEA:46788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CEL-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Caenorhabditis elegans)
GO:0000014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	single-stranded DNA specific endodeoxyribonuclease activity
GO:0000014	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ssDNA-specific endodeoxyribonuclease activity
GO:0000014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded DNA endodeoxyribonuclease activity
REACT:R-DDI-9660557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds RAL GDS proteins (Dictyostelium discoideum)
REACT:R-HSA-112055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Abortive Initiation At Type 1 Open Promoters (Homo sapiens)
RHEA:23156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O
RHEA:31577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGMP + diphosphate + H(+) => 8-oxo-dGTP + H2O
RHEA:22759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + O2 <=> a long-chain fatty aldehyde + H2O2
RHEA:66346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O
RHEA:41578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+) => dTDP-beta-L-mycarose + erythronolide B
GO:0019203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbohydrate phosphatase activity
REACT:R-XTR-2076419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Xenopus tropicalis)
REACT:R-DDI-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)
RHEA:71908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide
REACT:R-DRE-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Danio rerio)
RHEA:62092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate
REACT:R-DME-210662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated HOP is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)
RHEA:61756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside A + UDP
REACT:R-DRE-2529020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates condensin I subunits (Danio rerio)
RHEA:55280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA
RHEA:64380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + phytyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2
RHEA:60340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-HSA-168870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuraminidase enzymatic release from sialic acid (Homo sapiens)
RHEA:51077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate => 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-349593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with Fibronectin (Canis familiaris)
REACT:R-SSC-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Sus scrofa)
REACT:R-DME-201472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Drosophila melanogaster)
REACT:R-MMU-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
RHEA:14528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + beta-cyclopiazonate <=> AH2 + alpha-cyclopiazonate
REACT:R-GGA-3907292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Gallus gallus)
RHEA:34816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 NADP(+) + tetrahydrocurcumin => curcumin + 2 H(+) + 2 NADPH
REACT:R-CEL-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Caenorhabditis elegans)
REACT:R-SSC-391168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP gamma binds CD47 (Sus scrofa)
RHEA:58955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh1 + H(+) + UDP
RHEA:24502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + phosphate => adenosine 5'-tetraphosphate + H2O
REACT:R-XTR-109534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Xenopus tropicalis)
RHEA:67524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphopyrinase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced diphosphopyridine nucleotide diaphorase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:acceptor oxidoreductase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydronicotinamide adenine dinucleotide dehydrogenase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type I dehydrogenase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH oxidoreductase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H(+) + NADH = AH2 + NAD(+)
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphopyridine diaphorase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPNH diaphorase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH2 dehydrogenase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH dehydrogenase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	diaphorase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADH:cytochrome c oxidoreductase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type 1 dehydrogenase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c reductase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH hydrogenase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrocodehydrogenase I dehydrogenase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH:(acceptor) oxidoreductase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NADH-menadione oxidoreductase activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-NADH dehydrogenase dinucleotide activity
GO:0003954	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH diaphorase activity
REACT:R-GGA-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Gallus gallus)
REACT:R-RNO-77301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Rattus norvegicus)
RHEA:21340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lignostilbene alphabeta-dioxygenase"
RHEA:21340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin
RHEA:21340	skos:prefLabel	"lignostilbene alphabeta-dioxygenase"
REACT:R-DDI-804969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B1 hydrogenates E1 to EST17b (Dictyostelium discoideum)
RHEA:42413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-bisphosphoglycerate + ATP + H(+) => ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate
REACT:R-CEL-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Caenorhabditis elegans)
REACT:R-BTA-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)
RHEA:43251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate
EC:1.14.13.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NADH or NADPH as one donor, and incorporation of one atom of oxygen"
EC:1.14.13.-	skos:prefLabel	"With NADH or NADPH as one donor, and incorporation of one atom of oxygen"
REACT:R-BTA-9618378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 binds the Nup107-Nup160 complex (Bos taurus)
RHEA:16702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + NAD(+) => estrone + H(+) + NADH
REACT:R-MMU-381608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC2 (Mus musculus)
RHEA:13857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichylphosphate-glucose phosphodiesterase"
RHEA:13857	skos:prefLabel	"dolichylphosphate-glucose phosphodiesterase"
RHEA:13857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + H2O = a dolichyl phosphate + D-glucose + H(+)
RHEA:48868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide
REACT:R-CEL-201810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ligand trap binds the ligand BMP2, blocking BMP signalling (Caenorhabditis elegans)
REACT:R-DME-176664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + PAPS => estrone 3-sulfate + PAP (Drosophila melanogaster)
REACT:R-XTR-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Xenopus tropicalis)
REACT:R-RNO-2046096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Rattus norvegicus)
RHEA:63207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanoyl-[ACP] <=> H(+) + holo-[ACP] + octadecanoate
REACT:R-DRE-8952058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 binds RUNX3 and displaces EP300 (Danio rerio)
RHEA:62275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine
REACT:R-RNO-6809521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPIF binds bacteria (Rattus norvegicus)
REACT:R-DME-109278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Drosophila melanogaster)
RHEA:71810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + NAD(+) <=> an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide
REACT:R-SSC-5682377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 de-lipidation by ATG4 (Sus scrofa)
REACT:R-HSA-9613497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unwinding DNA for the nascent transcript (Homo sapiens)
REACT:R-DDI-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Dictyostelium discoideum)
REACT:R-HSA-9024726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 (Homo sapiens)
REACT:R-DRE-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Danio rerio)
RHEA:17506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(long-chain fatty acyl)ethanolamine => a long-chain fatty acid + ethanolamine
RHEA:66873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Bos taurus)
RHEA:31356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + H(+) + NADH + O2 => formaldehyde + H2O + methanethiol + NAD(+)
RHEA:62169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiose => acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine
REACT:R-HSA-446077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP230 interacts with keretin K5/K14 (Homo sapiens)
GO:0008145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalkylamine binding
RHEA:46062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-GGA-198599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MDM2 (Gallus gallus)
RHEA:31782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an all-trans-retinyl ester + H2O <=> 13-cis-retinol + a fatty acid + H(+)
RHEA:43391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3,4-bisphosphate + H2O <=> 1D-myo-inositol 3-phosphate + phosphate
REACT:R-RNO-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Rattus norvegicus)
REACT:R-BTA-391372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRH1,2 (Bos taurus)
RHEA:67067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + asnovolin K <=> A + asnovolin A
RHEA:54973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]
RHEA:67200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyltyramine = acetate + tyramine
RHEA:29309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + formaldehyde + 2 H(+) + H2O + sulfite => FMNH2 + methanesulfonate + O2
RHEA:67358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => (2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA
REACT:R-DRE-548815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Danio rerio)
GO:0030629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U6 snRNA 3'-end binding
GO:0030629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U6 snRNA 3' end binding
REACT:R-DME-209313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of HH (Drosophila melanogaster)
GO:0140684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9me2/H3K9me3 demethylase activity
GO:0140684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-tri/dimethyl-lysine-9 demethylase activity
GO:0140684	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K9me2 demethylase activity
GO:0140684	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H3K9me3 demethylase activity
REACT:R-HSA-202939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of E-Cadherin (Homo sapiens)
REACT:R-BTA-936563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of DDX58 (Bos taurus)
RHEA:45436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate
REACT:R-SSC-109343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Sus scrofa)
RHEA:30602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 3 A <=> 3 AH2 + all-trans-neurosporene
GO:0046558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-arabanase activity
GO:0046558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-alpha-1,5-arabanase activity
GO:0046558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity
GO:0046558	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,5-alpha-L-arabinanase activity
GO:0046558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinan endo-1,5-alpha-L-arabinosidase activity
REACT:R-CFA-9012349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)
RHEA:43725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]
RHEA:55211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine 1-phosphate <=> (2R)-hydroxyhexadecanal + phosphoethanolamine
REACT:R-HSA-203716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)
GO:0047006	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	20alpha-hydroxysteroid dehydrogenase
GO:0047006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
GO:0047006	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	20alpha-HSD
GO:0047006	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	20alpha-hydroxy steroid dehydrogenase activity
GO:0047006	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	20alpha-HSDH
GO:0047006	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity
REACT:R-RNO-1918092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIP (STUB1) mediates ubiquitination of ERBB2 (Rattus norvegicus)
REACT:R-DRE-434362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment Of Cytoplasmic Proteins To Vesicles (Danio rerio)
GO:0047803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cysteine (sulfite) lyase activity
GO:0047803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine lyase activity
GO:0047803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)
GO:0047803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine hydrogen-sulfide-lyase (adding sulfite)
REACT:R-BTA-2424480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
REACT:R-BTA-444661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR2 binds HCAR2 ligands (Bos taurus)
REACT:R-HSA-193766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
RHEA:52271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(aminomethyl)indole + S-adenosyl-L-methionine <=> (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine
GO:0035273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phthalate binding
RHEA:66094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine
REACT:R-CFA-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Canis familiaris)
RHEA:30999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = cucurbitadienol
RHEA:30999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cucurbitadienol synthase"
RHEA:30999	skos:prefLabel	"cucurbitadienol synthase"
REACT:R-HSA-508561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Homo sapiens)
RHEA:21970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate + phosphate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate
REACT:R-DDI-8931974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Dictyostelium discoideum)
REACT:R-HSA-9666383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F8 variant is not cleaved by thrombin (Homo sapiens)
REACT:R-BTA-9703895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds CASR agonists (Bos taurus)
REACT:R-BTA-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Bos taurus)
RHEA:55626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+) => an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O
RHEA:21768	skos:prefLabel	"N-methylalanine dehydrogenase"
RHEA:21768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-methylalanine dehydrogenase"
RHEA:21768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-methyl-L-alanine + NADP(+) = H(+) + methylamine + NADPH + pyruvate
RHEA:59231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-alpha-D-quinovose <=> 6-sulfo-beta-D-quinovose
REACT:R-RNO-2179415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Rattus norvegicus)
RHEA:18266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH
RHEA:51401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + serotonin => CoA + H(+) + N-octadecanoyl-serotonin
REACT:R-SCE-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Saccharomyces cerevisiae)
REACT:R-MMU-70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Mus musculus)
RHEA:56480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O
RHEA:69912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(out) + 2 Na(+)(out) => adenosine(in) + 2 Na(+)(in)
RHEA:39471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)
REACT:R-MMU-9629918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 translocates to the nucleus (Mus musculus)
RHEA:61242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + H2O2 + NH4(+) => H2O + L-phenylalanine + O2
REACT:R-RNO-199144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin 2 binds CD226 (Rattus norvegicus)
REACT:R-SSC-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Sus scrofa)
GO:0022873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity
GO:0022873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose PTS transporter activity
REACT:R-GGA-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Gallus gallus)
RHEA:29556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + 2 H(+) + UMP
REACT:R-CFA-76496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Canis familiaris)
REACT:R-CEL-389622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)
REACT:R-DRE-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
RHEA:16135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1)-acetylspermine + O2
RHEA:24771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + NAD(+) <=> chlorophyllide b + H(+) + NADH
RHEA:44839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside NOR2 (d18:1(4E)) + H(+) + UDP
REACT:R-HSA-8950389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Stress-70 protein, mitochondrial (Homo sapiens)
REACT:R-SCE-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Saccharomyces cerevisiae)
RHEA:71776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(out) + H(+)(out) => acetoacetate(in) + H(+)(in)
RHEA:56942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate => S-methyl-5-thio-D-ribulose 1-phosphate
REACT:R-HSA-9750666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds ST (Homo sapiens)
REACT:R-XTR-2404137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Xenopus tropicalis)
REACT:R-GGA-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)
REACT:R-BTA-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Bos taurus)
RHEA:40275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2
RHEA:26096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)
REACT:R-DME-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Drosophila melanogaster)
REACT:R-CEL-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Caenorhabditis elegans)
REACT:R-DME-1592297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full activation of MMP1 (Drosophila melanogaster)
REACT:R-MMU-373745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK1 homophillic interaction (Mus musculus)
REACT:R-DME-6814153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADO oxidises 2AET to HTAU (Drosophila melanogaster)
RHEA:72510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + prostaglandin F2alpha(out) <=> 2-oxoglutarate(out) + prostaglandin F2alpha(in)
REACT:R-BTA-8866269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB bind GPCRs (Bos taurus)
RHEA:33847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + tetracosanoate
RHEA:25633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laricitrin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + syringetin
REACT:R-GGA-379044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gs-activating GPCR acts as a GEF for Gs (Gallus gallus)
RHEA:43661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + propanoyl-CoA => ADP + H(+) + methylmalonyl-CoA + phosphate
GO:0080078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
REACT:R-XTR-5357845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is deubiquitinated (Xenopus tropicalis)
REACT:R-DRE-8950778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dimerizes (Danio rerio)
REACT:R-CFA-2213235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of nonameric complex in the endocytic pathway (Canis familiaris)
EC:3.4.21.42	skos:prefLabel	"complement subcomponent C1s"
EC:3.4.21.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"complement subcomponent C1s"
EC:3.4.21.42	skos:altLabel	"C1s esterase"
REACT:R-HSA-9605052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H3 mRNA is translated (Homo sapiens)
RHEA:62764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:52128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)
REACT:R-CFA-1981157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of collagen propeptide hydroxylysines (Canis familiaris)
RHEA:12856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> dhurrin + H(+) + UDP
REACT:R-SSC-174444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C-strand Okazaki fragments (Sus scrofa)
REACT:R-CFA-8863463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 binds SYT proteins (Canis familiaris)
RHEA:32658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + eugenol + NADP(+) <=> a coniferyl ester + NADPH
RHEA:19325	skos:altLabel	"quinolin-4(1H)-one 3-monooxygenase"
RHEA:19325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + quinolin-4-ol = H2O + NAD(+) + quinoline-3,4-diol
RHEA:19325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyquinoline 3-monooxygenase"
RHEA:19325	skos:prefLabel	"4-hydroxyquinoline 3-monooxygenase"
RHEA:19325	skos:altLabel	"1-H-4-oxoquinoline 3-monooxygenase"
REACT:R-CFA-9759202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Canis familiaris)
REACT:R-MMU-202724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-selectin binds P-selectin ligand (Mus musculus)
RHEA:22186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acenaphthene-1,2-dione + 2 H(+) + 2 NADPH => (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+)
REACT:R-GGA-5654148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR3 (Gallus gallus)
REACT:R-DDI-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Dictyostelium discoideum)
REACT:R-CFA-4608855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRICKLE1 is degraded by the proteasome (Canis familiaris)
REACT:R-DME-74737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)
RHEA:42058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinal + H(+) + NADH => 13-cis-retinol + NAD(+)
RHEA:45739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA
REACT:R-SCE-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Saccharomyces cerevisiae)
REACT:R-CFA-3827958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by MMP9, KLK7 (Canis familiaris)
RHEA:59639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotriose + O2 <=> D-xylotriono-1,5-lactone + H2O2
REACT:R-DDI-77586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Dictyostelium discoideum)
REACT:R-HSA-8867754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
RHEA:50219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate
RHEA:63723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	losartan + UDP-alpha-D-glucuronate <=> losartan-2-N-beta-D-glucuronide + UDP
RHEA:53547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:36118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A3 + S-adenosyl-L-methionine <=> O-methyl gibberellin A3 + S-adenosyl-L-homocysteine
RHEA:55487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:62621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + a hydroperoxide => [thioredoxin]-disulfide + an alcohol + H2O
REACT:R-CFA-9604480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFkB complex translocates from the cytosol to the nucleus (Canis familiaris)
GO:0008910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neomycin phosphotransferase activity
GO:0008910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neomycin-kanamycin phosphotransferase activity
GO:0008910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:kanamycin 3'-O-phosphotransferase activity
GO:0008910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kanamycin kinase (phosphorylating)
GO:0008910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kanamycin kinase activity
GO:0008910	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	APH(3') activity
GO:0008910	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aminoglycoside 3'-phosphotransferase activity
REACT:R-HSA-166175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Homo sapiens)
REACT:R-HSA-909718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of p-STAT1 homodimer (Homo sapiens)
RHEA:51581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) => a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
REACT:R-CFA-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Canis familiaris)
RHEA:50981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E1(out) => prostaglandin E1(in)
RHEA:53356	skos:prefLabel	"tRNA-dihydrouridine(20a/20b) synthase [NAD(P)(+)]"
RHEA:53356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-dihydrouridine(20a/20b) synthase [NAD(P)(+)]"
RHEA:53356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(20b) in tRNA + NADP(+) = H(+) + NADPH + uridine(20b) in tRNA
RHEA:56955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + pyruvate <=> CDP + H(+) + phosphoenolpyruvate
REACT:R-CFA-193719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Canis familiaris)
RHEA:32626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
REACT:R-CFA-5654615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:pFRS binds GRB2:SOS1 (Canis familiaris)
REACT:R-SSC-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Sus scrofa)
REACT:R-HSA-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Homo sapiens)
REACT:R-DME-8854302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D7 binds the TSC1-TSC2 complex (Drosophila melanogaster)
REACT:R-MMU-9793680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)
RHEA:10509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate
RHEA:57210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glyoxal + L-cysteinyl-[protein]
RHEA:24794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate
REACT:R-SPO-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Schizosaccharomyces pombe)
REACT:R-MMU-174757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Mus musculus)
REACT:R-CFA-2160874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses (HA)50 (Canis familiaris)
RHEA:25706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-dihomomethionine = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O
RHEA:33405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-threonyl-5'-AMP => ATP + L-threonine
REACT:R-HSA-6810159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB2 chromatin is activated (Homo sapiens)
REACT:R-BTA-5692754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B dephosphorylate p-3S,T MAPK6 (Bos taurus)
REACT:R-MMU-5683831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCDC59 binds TTF1 (Mus musculus)
RHEA:63048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pravastatin lactone = H(+) + pravastatin
REACT:R-CFA-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Canis familiaris)
GO:0050346	skos:prefLabel	"trans-L-3-hydroxyproline dehydratase"
GO:0050346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-L-3-hydroxyproline dehydratase"
GO:0050346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O
GO:0050346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-L-3-hydroxyproline hydro-lyase activity
GO:0050346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-L-3-hydroxyproline dehydratase activity
GO:0050346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)
REACT:R-RNO-2161293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin forms aggregate globules (Rattus norvegicus)
REACT:R-CEL-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Caenorhabditis elegans)
REACT:R-GGA-9023626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)
REACT:R-SSC-9627056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procaspase 9 forms dimer (Sus scrofa)
RHEA:30136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H2O => CoA + dodecanoate + H(+)
REACT:R-HSA-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Homo sapiens)
REACT:R-HSA-380048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)
REACT:R-HSA-202731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM3 dimerises (Homo sapiens)
REACT:R-DME-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)
RHEA:33233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme d cis-diol => H2O2 + heme b
RHEA:41209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O
REACT:R-BTA-977359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to membrane-associated Factor H:C3b (Bos taurus)
REACT:R-GGA-264695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Gallus gallus)
RHEA:22604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannose isomerase"
RHEA:22604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose = D-fructose
RHEA:22604	skos:altLabel	"D-mannose isomerase"
RHEA:22604	skos:prefLabel	"mannose isomerase"
RHEA:56199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP
RHEA:69455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH <=> 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)
REACT:R-HSA-9728747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
REACT:R-DRE-2064417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-1 (TJP1) (Danio rerio)
RHEA:64256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + glycine = CoA + H(+) + N-dodecanoylglycine
RHEA:22666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-O-sinapoyl beta-D-glucose + D-glucose => 2 1-O-(trans-sinapoyl)-beta-D-glucose
REACT:R-DRE-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Danio rerio)
REACT:R-MMU-5624952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the retrograde IFT train (Mus musculus)
REACT:R-RNO-416690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4A binds to PLXND1 (Rattus norvegicus)
REACT:R-SSC-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Sus scrofa)
RHEA:71584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(in) + Na(+)(in) => L-histidine(out) + Na(+)(out)
REACT:R-RNO-5607742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Rattus norvegicus)
GO:0097157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-messenger RNA intronic binding
GO:0097157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-mRNA intronic binding
REACT:R-BTA-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Bos taurus)
REACT:R-HSA-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
RHEA:11234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + sulfate => 3'-phosphoadenylyl sulfate + H2O
REACT:R-SSC-5676596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds BAFFR:BAFF (Sus scrofa)
REACT:R-CEL-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Caenorhabditis elegans)
REACT:R-DRE-392835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 sequesters Raf1 to inhibit ERK cascade (Danio rerio)
REACT:R-CFA-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Canis familiaris)
REACT:R-CFA-199112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRTAM binds to NECL2 (Canis familiaris)
REACT:R-GGA-373071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR7 binds CCL19 and 21 ligands (Gallus gallus)
REACT:R-BTA-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)
REACT:R-DRE-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Danio rerio)
REACT:R-SCE-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Saccharomyces cerevisiae)
RHEA:42560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA
RHEA:42560	skos:prefLabel	"mitochondrial tRNA pseudouridine(27/28) synthase"
RHEA:42560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mitochondrial tRNA pseudouridine(27/28) synthase"
REACT:R-BTA-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Bos taurus)
RHEA:10783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH
RHEA:71708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-phenylalanyl-L-phenylalanine(out) => H(+)(in) + L-phenylalanyl-L-phenylalanine(in)
REACT:R-DDI-977317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Dictyostelium discoideum)
RHEA:39837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
GO:0005246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium channel regulator activity
RHEA:54781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
REACT:R-HSA-5389848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)
RHEA:46730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2 => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2
RHEA:71606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + oxaloacetate(in) <=> 2-oxoglutarate(in) + oxaloacetate(out)
REACT:R-GGA-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Gallus gallus)
REACT:R-PFA-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Plasmodium falciparum)
REACT:R-MMU-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Mus musculus)
RHEA:35017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	riboflavin(out) => riboflavin(in)
REACT:R-CFA-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Canis familiaris)
RHEA:38521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-octadecanoylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O
REACT:R-HSA-193705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)
RHEA:29925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A
REACT:R-CFA-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Canis familiaris)
RHEA:24904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-phosphoguanylyl(3'->5')guanosine + H(+) => 3',3'-c-di-GMP + H2O
REACT:R-BTA-8852298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Bos taurus)
RHEA:53334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2
RHEA:10303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + NAD(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH
REACT:R-BTA-8950485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Bos taurus)
RHEA:28935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate
REACT:R-XTR-2203516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-1-Microglobulin is cleaved (Xenopus tropicalis)
RHEA:53846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxoglycolithocholate + H(+) + NADH => glycochenodeoxycholate + NAD(+)
RHEA:32071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate
RHEA:64824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthaleneacetamide + H2O = 1-naphthaleneacetate + NH4(+)
REACT:R-MMU-193065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Mus musculus)
REACT:R-SSC-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Sus scrofa)
RHEA:23898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-2,5-hexodiulosonate => 5-dehydro-4-deoxy-D-glucuronate
RHEA:22788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + H(+) + L-methionine
RHEA:22788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thetin--homocysteine S-methyltransferase"
RHEA:22788	skos:prefLabel	"thetin--homocysteine S-methyltransferase"
RHEA:56253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP
REACT:R-BTA-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Bos taurus)
RHEA:70173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + pemetrexed(out) => H(+)(in) + pemetrexed(in)
REACT:R-SSC-69074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex (Sus scrofa)
RHEA:28254	skos:prefLabel	"(Z)-3-hexen-1-ol acetyltransferase"
RHEA:28254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-hex-3-en-1-ol + acetyl-CoA = (3Z)-hex-3-en-1-yl acetate + CoA
RHEA:28254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(Z)-3-hexen-1-ol acetyltransferase"
RHEA:29013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + H(+)(out) => 2-oxoglutarate(in) + H(+)(in)
REACT:R-RNO-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Rattus norvegicus)
REACT:R-DME-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)
RHEA:42605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)
RHEA:11706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + N-(aminomethyl)urea => 2 H(+) + N-(carboxyaminomethyl)urea
RHEA:11777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:12047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + H2O <=> a diacylglycerol + a fatty acid + H(+)
REACT:R-BTA-9757688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDN (Bos taurus)
RHEA:28148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-398193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC beta-mediated PIP2 hydrolysis (Mus musculus)
REACT:R-BTA-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Bos taurus)
REACT:R-SCE-8959571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Saccharomyces cerevisiae)
REACT:R-CFA-8852509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL-LK binds carbohydrates on target cell surface (Canis familiaris)
REACT:R-SSC-193964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 21-hydroxylates PROG (Sus scrofa)
REACT:R-XTR-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Xenopus tropicalis)
RHEA:11805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + H2O + NAD(+) => an aromatic carboxylate + 2 H(+) + NADH
REACT:R-GGA-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Gallus gallus)
REACT:R-SPO-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Schizosaccharomyces pombe)
REACT:R-MMU-109759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Mus musculus)
REACT:R-GGA-8850786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK12 (Gallus gallus)
RHEA:42630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(747) in 23S rRNA
RHEA:19489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide = 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)
REACT:R-CFA-8952382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 polyubiquitinates RUNX3 (Canis familiaris)
REACT:R-CFA-9610163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAF autophosphorylates downstream of RAP1 and NGF (Canis familiaris)
RHEA:68932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + octanoate = AMP + diphosphate + NADP(+) + octanal
REACT:R-HSA-1433506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APS (Homo sapiens)
REACT:R-MMU-8987230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Mus musculus)
REACT:R-SSC-1602473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP1 (Sus scrofa)
REACT:R-MMU-4090288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate MBD1 with SUMO1 (Mus musculus)
GO:0047203	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity
GO:0047203	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	13-hydroxylupanine acyltransferase activity
GO:0047203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxylupinine O-tigloyltransferase activity
GO:0047203	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity
GO:1902098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol binding
GO:1902098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxycholecalciferol binding
GO:1902098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25(OH)2 vitamin D3 binding
GO:1902098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25-dihydroxyvitamin D3 binding
GO:1902098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxyvitamin D3 binding
GO:1902098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25(OH)2D3 binding
GO:1902098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25-dihydroxycholecalciferol binding
GO:1902098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hormonally active vitamin D3 binding
REACT:R-BTA-5607737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 oligomerizes (Bos taurus)
RHEA:38379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-HSA-5665767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FMNL3 binds G-actin (Homo sapiens)
REACT:R-HSA-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Homo sapiens)
REACT:R-BTA-9731632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)
REACT:R-CFA-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Canis familiaris)
REACT:R-DRE-6809264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Danio rerio)
REACT:R-RNO-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Rattus norvegicus)
REACT:R-SSC-913374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits SHIP (Sus scrofa)
RHEA:24278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl phosphate + phosphate => acetate + diphosphate
RHEA:58773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)
RHEA:11550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O
RHEA:32874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + H2O <=> a carboxylate + glycerol + H(+)
REACT:R-DRE-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Danio rerio)
RHEA:33803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidinal + NAD(+) = 2 H(+) + L-histidine + NADH
RHEA:61514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malvidin 3-O-beta-D-glucoside + UDP => malvidin + UDP-alpha-D-glucose
RHEA:50621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:16862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine => (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate
RHEA:50588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH
REACT:R-CFA-205244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CBL to KIT (Canis familiaris)
RHEA:63268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:47265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanoate + ATP + CoA => AMP + diphosphate + pristanoyl-CoA
REACT:R-SPO-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Schizosaccharomyces pombe)
RHEA:11001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-carbamoyl-D-amino acid + 2 H(+) + H2O => a D-alpha-amino acid + CO2 + NH4(+)
REACT:R-HSA-9603905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of NLRP3 gene (Homo sapiens)
REACT:R-BTA-389632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Bos taurus)
RHEA:37702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-448629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33 binds IL1RL1 (Homo sapiens)
REACT:R-CFA-9641096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Canis familiaris)
REACT:R-XTR-1067640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R-2 (Xenopus tropicalis)
REACT:R-SSC-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Sus scrofa)
GO:0102949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-rhamnosyltransferase activity
RHEA:21670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in) => ATP + H2O + sn-glycerol 3-phosphate(out)
REACT:R-XTR-265296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Xenopus tropicalis)
REACT:R-MMU-68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated geminin is degraded by the proteasome (Mus musculus)
REACT:R-DDI-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Dictyostelium discoideum)
REACT:R-XTR-8867044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EPS15, EPN1, EPS15L1 (Xenopus tropicalis)
REACT:R-BTA-5649726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Bos taurus)
REACT:R-CEL-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Caenorhabditis elegans)
REACT:R-BTA-451311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca-permeable Kainate receptors (Bos taurus)
REACT:R-HSA-70940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Homo sapiens)
RHEA:65100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl-acylglycerol + CoA
RHEA:17625	skos:altLabel	"D-lysopine synthase"
RHEA:17625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysopine + H2O + NADP(+) = H(+) + L-lysine + NADPH + pyruvate
RHEA:17625	skos:altLabel	"lysopine dehydrogenase"
RHEA:17625	skos:prefLabel	"D-lysopine dehydrogenase"
RHEA:17625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-lysopine dehydrogenase"
RHEA:40338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:51197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + Na(+)(out) + serotonin(out) => chloride(in) + Na(+)(in) + serotonin(in)
GO:0034038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	spermidine dehydrogenase
GO:0034038	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(4-aminobutyl)lysine synthase
GO:0034038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyhypusine synthase activity
GO:0034038	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	eIF-5A-deoxyhypusine synthase activity
REACT:R-SPO-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Schizosaccharomyces pombe)
GO:0010211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAA-Leu conjugate hydrolase activity
RHEA:36263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyurea + O-acetyl-L-serine = acetate + H(+) + O-ureido-L-serine
RHEA:36263	skos:prefLabel	"O-ureido-L-serine synthase"
RHEA:36263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-ureido-L-serine synthase"
RHEA:47960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(tele)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate
REACT:R-MMU-1482794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Mus musculus)
REACT:R-BTA-934559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)
REACT:R-CFA-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Canis familiaris)
REACT:R-DRE-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Danio rerio)
GO:0001156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIIC-class transcription factor complex binding
GO:0001156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIIC-class transcription factor binding
REACT:R-BTA-9701488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates JAK3 (Bos taurus)
GO:0050617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PebA
GO:0050617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity
REACT:R-CEL-8850539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GNB5:RGS dimers from CCT/TRiC (Caenorhabditis elegans)
RHEA:43766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + chenodeoxycholoyl-CoA + diphosphate => ATP + chenodeoxycholate + CoA
REACT:R-HSA-434989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA7A binds to PLXNC1 (Homo sapiens)
REACT:R-DDI-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Dictyostelium discoideum)
REACT:R-HSA-166082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
REACT:R-CFA-9696266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds effectors (Canis familiaris)
REACT:R-HSA-5617825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi (Homo sapiens)
RHEA:40931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ornithine + O2 = (3S)-3-hydroxy-L-ornithine + CO2 + succinate
REACT:R-XTR-390427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Xenopus tropicalis)
RHEA:59694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotrionate + H(+) => D-cellotriono-1,5-lactone + H2O
RHEA:28305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene C
REACT:R-BTA-114275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BAX at the mitochondrial membrane (Bos taurus)
REACT:R-DDI-8954398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer hydrolyses cardiolipin to PA and PG (Dictyostelium discoideum)
GO:0046989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity
REACT:R-BTA-9624893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN stimulates fusion of nuclear envelope (NE) membranes (Bos taurus)
REACT:R-CFA-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Canis familiaris)
REACT:R-DDI-111253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Dictyostelium discoideum)
REACT:R-GGA-983138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC heterotrimer to ER exit site (Gallus gallus)
RHEA:71151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one = (E)-caffeoylpyruvate + CO2 + hnu
REACT:R-DRE-6797627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPG hydrolyses L-Asn to L-Asp (Danio rerio)
RHEA:41887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-HSA-9033292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2 and CDK5 promote activation of RAC1 by TIAM1 (Homo sapiens)
REACT:R-DME-6810076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDO oxidizes D-Asp to OA (Drosophila melanogaster)
RHEA:27283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)
RHEA:49516	skos:prefLabel	"mRNA N(1)-methyladenine demethylase"
RHEA:49516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate
RHEA:49516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mRNA N(1)-methyladenine demethylase"
RHEA:49516	skos:altLabel	"ALKBH3"
REACT:R-SPO-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)
REACT:R-MMU-3928598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of p190RhoGEF to p-FAK (Mus musculus)
RHEA:49564	skos:prefLabel	"2-epi-valiolone synthase"
RHEA:49564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-epi-valiolone synthase"
RHEA:49564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate
REACT:R-BTA-8851298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR143 binds L-Dopa (Bos taurus)
REACT:R-RNO-3229181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALM1:Ca2+ binds CNG channel (Rattus norvegicus)
REACT:R-RNO-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Rattus norvegicus)
RHEA:66410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O
REACT:R-GGA-351455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of NBS1 by ATM (Gallus gallus)
REACT:R-DRE-390252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Danio rerio)
REACT:R-XTR-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Xenopus tropicalis)
REACT:R-XTR-1433415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 (Xenopus tropicalis)
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-joining enzyme
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic repair enzyme
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleic joinase
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase (ATP) activity
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic-joining enzyme
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polynucleotide ligase
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic acid repair enzyme
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic acid-joining enzyme
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleic acid joinase
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleic acid ligase
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA joinase activity
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA repair enzyme activity
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleic ligase
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleate ligase
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sealase activity
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide ligase (ATP) activity
GO:0003910	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polydeoxyribonucleotide synthase (ATP) activity
REACT:R-XTR-6781814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 deubiquitinates RNF123 (Xenopus tropicalis)
RHEA:28873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructuronate(out) + H(+)(out) => D-fructuronate(in) + H(+)(in)
RHEA:32554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> (S)-alpha-terpineol + diphosphate
RHEA:65653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine => a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine
RHEA:48582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate, water dikinase] + diphosphate => [pyruvate, water dikinase]-phosphate + H(+) + phosphate
GO:0050782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactose uniporter activity
GO:0050782	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	galactose, glucose uniporter activity
RHEA:69502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide => L-arginyl-[protein] + NAD(+)
REACT:R-MMU-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Mus musculus)
RHEA:45505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]
REACT:R-SSC-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Sus scrofa)
RHEA:54478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+) => 1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:35270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol(in) <=> ethanol(out)
REACT:R-HSA-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Homo sapiens)
REACT:R-DRE-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Danio rerio)
REACT:R-CFA-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Canis familiaris)
REACT:R-CEL-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Caenorhabditis elegans)
REACT:R-SSC-195378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of VEGF proteins (Sus scrofa)
REACT:R-DME-4719413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO2 (Drosophila melanogaster)
REACT:R-DRE-5624131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC119B binds myristoylated proteins (Danio rerio)
RHEA:32630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
REACT:R-HSA-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Homo sapiens)
REACT:R-XTR-8948231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)
REACT:R-DME-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Drosophila melanogaster)
REACT:R-RNO-8866553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded CFTR is degraded by the 26S proteasome (Rattus norvegicus)
RHEA:67155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] <=> L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]
REACT:R-BTA-5649723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Bos taurus)
REACT:R-DRE-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Danio rerio)
RHEA:49973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Drosophila melanogaster)
RHEA:44727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-saturated fatty aldehyde + NADP(+) <=> (2E)-fatty aldehyde + H(+) + NADPH
RHEA:44586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O
REACT:R-HSA-3249378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING recruits TBK1 and STAT6 (Homo sapiens)
REACT:R-DRE-3318413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Danio rerio)
RHEA:29182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 2 O2 <=> a menaquinone + 2 H(+) + 2 superoxide
REACT:R-XTR-6799191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Xenopus tropicalis)
REACT:R-RNO-3134946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 ubiquitination by TRIM21 (Rattus norvegicus)
REACT:R-DME-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Drosophila melanogaster)
REACT:R-DME-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Drosophila melanogaster)
RHEA:68723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-210277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-1 (Mus musculus)
REACT:R-SSC-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Sus scrofa)
RHEA:39985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O => a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:71829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate(out) + H(+)(out) => arsenate(in) + H(+)(in)
RHEA:19140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + AH2 + O2 <=> 6beta-hydroxyestradiol-17beta + A + H2O
REACT:R-SSC-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Sus scrofa)
RHEA:30077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine + D-ribose 5-phosphate => CMP + H2O
GO:0047988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyacid-oxoacid transhydrogenase activity
GO:0047988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transhydrogenase, hydroxy acid-oxo acid
GO:0047988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity
REACT:R-DRE-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Danio rerio)
REACT:R-CFA-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Canis familiaris)
REACT:R-MMU-8874745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Mus musculus)
REACT:R-GGA-204824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Ang4 (Gallus gallus)
GO:0018716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenanthrol glycosyltransferase activity
REACT:R-SSC-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Sus scrofa)
RHEA:47071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O
GO:0016499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orexin receptor activity
REACT:R-DRE-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Danio rerio)
RHEA:69420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + iodide = H2O + hypoiodite
REACT:R-HSA-6790022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of STAT3-upregulated plasma membrane proteins (Homo sapiens)
REACT:R-SSC-159762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)
REACT:R-MMU-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Mus musculus)
RHEA:47689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-hydroxy-L-proline + NADP(+) => Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH
REACT:R-DRE-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Danio rerio)
RHEA:61569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine
REACT:R-HSA-428511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK binds ROBO1:SLIT2 (Homo sapiens)
RHEA:27975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxy-5,6,7,8-tetrahydropterin + H(+) => 7-carboxy-7-deazaguanine + NH4(+)
REACT:R-DME-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Drosophila melanogaster)
REACT:R-HSA-5690759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Homo sapiens)
REACT:R-RNO-5218643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90AA1 binds p-6Y-VEGFR2 (Rattus norvegicus)
REACT:R-CFA-9013109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GEFs activate RHOC (Canis familiaris)
REACT:R-CFA-389463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteinase-activated receptors can bind thrombin (Canis familiaris)
REACT:R-SSC-9032073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-phosphorylated FRS2 binds GRB2 (Sus scrofa)
REACT:R-HSA-6790087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HVEM induses BTLA phosphorylation (Homo sapiens)
REACT:R-DME-209141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane (Drosophila melanogaster)
REACT:R-BTA-110356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MPG glycosylase by APEX1 at the AP site (Bos taurus)
REACT:R-BTA-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Bos taurus)
RHEA:55045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-tetradecadienoyl-CoA + H2O => (3E,5Z)-tetradecadienoate + CoA + H(+)
REACT:R-XTR-168136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated JNKs phosphorylate c-JUN (Xenopus tropicalis)
GO:0031767	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gastric inhibitory polypeptide receptor ligand
GO:0031767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gastric inhibitory polypeptide receptor binding
REACT:R-CEL-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Caenorhabditis elegans)
REACT:R-DRE-5668414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Danio rerio)
RHEA:59404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine = D-homoserine
REACT:R-DME-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)
RHEA:63088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Danio rerio)
REACT:R-SSC-8874201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L3 (Sus scrofa)
GO:0071077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3'-phosphate-5'-phosphate transmembrane transporter activity
GO:0071077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate transmembrane transporter activity
GO:0071077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-diphosphate transporter activity
RHEA:69685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + daidzein + H(+) => daidzein 7-O-beta-D-glucoside + H2O
RHEA:14785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RNA uridylyltransferase"
RHEA:14785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide
RHEA:14785	skos:altLabel	"TUT"
RHEA:14785	skos:altLabel	"terminal uridylyltransferase"
RHEA:14785	skos:prefLabel	"RNA uridylyltransferase"
RHEA:47199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-DRE-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Danio rerio)
REACT:R-SPO-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)
REACT:R-HSA-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Homo sapiens)
REACT:R-XTR-109291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Xenopus tropicalis)
RHEA:65311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]
REACT:R-GGA-429441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK activation by SRC (Gallus gallus)
GO:0102684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine N-monooxygenase"
GO:0102684	skos:altLabel	"phenylalanine N-hydroxylase"
GO:0102684	skos:altLabel	"CYP79D16"
GO:0102684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine N-monooxygenase activity
GO:0102684	skos:prefLabel	"phenylalanine N-monooxygenase"
GO:0102684	skos:altLabel	"CYP79A2"
GO:0102684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-5362486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Gallus gallus)
REACT:R-HSA-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Homo sapiens)
REACT:R-HSA-2466749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol (Homo sapiens)
RHEA:47643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine
RHEA:64147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-methionine <=> (9Z)-octadecenoate + L-methionine
GO:0102547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosylglycerate hydrolase activity
RHEA:19135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyropyruvate + L-glutamate => 2-oxoglutarate + 3,3',5-triiodo-L-thyronine
RHEA:40208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenedioyl-CoA + H2O => (3S)-hydroxytetradecanedioyl-CoA
RHEA:20667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-glucitol + NADP(+)
REACT:R-HSA-419841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Light stimulates opsin receptors (Homo sapiens)
REACT:R-CFA-5692315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OX40L binds OX40 (Canis familiaris)
GO:0099085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIF dechlorinase activity
GO:0099085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one 3(5)-dechlorinase activity
GO:0099085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	differentiation-inducing factor dechlorinase activity
GO:0099085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIF-1 dechlorinase activity
GO:0099085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	differentiation-inducing factor 1 dechlorinase activity
GO:0099085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIF-1 3(5)-dechlorinase activity
GO:0099085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one 3(5)-dechlorinase activity
RHEA:70981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) + n H(+)(out) => 4-aminobutanoate(out) + n H(+)(in)
REACT:R-SSC-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Sus scrofa)
REACT:R-GGA-9667619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B,2 bind atosiban (Gallus gallus)
REACT:R-HSA-158399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein binds SERPING1 (Homo sapiens)
REACT:R-GGA-421471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylbilane => uroporphyrinogen I + H2O (Gallus gallus)
GO:0030739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-demethylpuromycin methyltransferase activity
GO:0030739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-demethylpuromycin O-methyltransferase activity
GO:0030739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity
REACT:R-MMU-177107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion and activation of the latent large complex of TGF-beta-1 (Mus musculus)
REACT:R-HSA-432121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL binds to LRP8 (Homo sapiens)
RHEA:40993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => (E)-4-coumaroyl-CoA + H2O
RHEA:66851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Cu(2+) + NADH <=> 2 Cu(+) + H(+) + NAD(+)
GO:0033837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity
GO:0033837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'GT
GO:0033837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin 3'-O-beta-glucosyltransferase activity
GO:0033837	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity
REACT:R-PFA-110133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Plasmodium falciparum)
REACT:R-PFA-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Plasmodium falciparum)
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA(guanine-26,N(2)-N(2)) methyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate guanine N2-methyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA 2,2-dimethylguanosine-26 methyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT11:TRMT112 methylates guanosine-10 in tRNA (Homo sapiens)
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer RNA guanine 2-methyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(2),N(2)-dimethylguanine tRNA methyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA(m(2,2)G26)dimethyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanine-N2-methylase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate guanine 2-methyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr) (Homo sapiens)
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2,N2-dimethylguanine tRNA methyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA(guanine-26,N2-N2) methyltransferase activity
GO:0004809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (guanine-N2-)-methyltransferase activity
REACT:R-DDI-75866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Dictyostelium discoideum)
RHEA:43045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecasphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylhexadecasphinganine
REACT:R-CFA-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Canis familiaris)
REACT:R-BTA-5578742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO1,2:small RNA complexes interact with chromatin (Bos taurus)
REACT:R-BTA-5617816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A  (Bos taurus)
REACT:R-MMU-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Mus musculus)
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate cleavage enzyme activity
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP citrate (pro-S)-lyase activity
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-citrate (pro-S)-lyase activity
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine triphosphate citrate lyase activity
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrate-ATP lyase activity
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-citric lyase activity
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-citrate (pro-S-)-lyase activity
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP citrate synthase activity
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citric cleavage enzyme activity
GO:0003878	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity
RHEA:62567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + A + H2O <=> (4S)-perillyl alcohol + AH2
GO:0070835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromium ion transmembrane transporter activity
GO:0019871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium channel inhibitor activity
RHEA:72447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate(in) + estrone 3-sulfate(out) = a dicarboxylate(out) + estrone 3-sulfate(in)
REACT:R-DRE-1504193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL is degraded by the proteasome (Danio rerio)
RHEA:30073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + butanoyl-CoA => acetyl-CoA + butanoate
RHEA:54908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (4E)-hexenoyl-CoA + NADP(+)
REACT:R-BTA-9749590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates ALB (Bos taurus)
REACT:R-CFA-379395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD deaminates 3MT to HVA (Canis familiaris)
REACT:R-DDI-209973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is diiodinated (Dictyostelium discoideum)
GO:0035673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligopeptide transmembrane transporter activity
GO:0035673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligopeptide transporter activity
RHEA:41527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + 5 malonyl-CoA <=> 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol
REACT:R-RNO-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-XTR-917814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Xenopus tropicalis)
RHEA:31451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol
REACT:R-GGA-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Gallus gallus)
REACT:R-CFA-2730847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP2 by PLCG (Canis familiaris)
RHEA:37801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 NAD(+) => 2 H(+) + 2 NADH + O2
REACT:R-DRE-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Danio rerio)
RHEA:13157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + CO2 + NADP(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH
RHEA:48776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)
REACT:R-MMU-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Mus musculus)
RHEA:43892	skos:altLabel	"cysteine desulfurylase"
RHEA:43892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine
RHEA:43892	skos:prefLabel	"cysteine desulfurase"
RHEA:43892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine desulfurase"
RHEA:19841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formylmethanofuran dehydrogenase"
RHEA:19841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:19841	skos:prefLabel	"formylmethanofuran dehydrogenase"
REACT:R-MMU-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Mus musculus)
REACT:R-XTR-8876283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Xenopus tropicalis)
RHEA:62148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + dTMP = dGDP + dTDP
REACT:R-SSC-6785933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT8 transfers Gal from UDP-Gal to CERA (Sus scrofa)
REACT:R-SCE-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Saccharomyces cerevisiae)
REACT:R-HSA-937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
REACT:R-BTA-5693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYM reduces P2C to PPCA (Bos taurus)
REACT:R-XTR-5667008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds RHPN1 or RHPN2 (Xenopus tropicalis)
REACT:R-RNO-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Rattus norvegicus)
EC:3.4.21.19	skos:prefLabel	"glutamyl endopeptidase"
EC:3.4.21.19	skos:altLabel	"staphylococcal serine proteinase"
EC:3.4.21.19	skos:altLabel	"protease V8"
EC:3.4.21.19	skos:altLabel	"endoproteinase Glu-C"
EC:3.4.21.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamyl endopeptidase"
EC:3.4.21.19	skos:altLabel	"V8 proteinase"
REACT:R-HSA-9694436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp15 forms a hexamer (Homo sapiens)
REACT:R-DDI-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Dictyostelium discoideum)
RHEA:30605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-phytofluene => 15-cis-phytoene + A
RHEA:44006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-methyl fatty acyl-CoA + AMP + diphosphate => 3-methyl fatty acid + ATP + CoA
REACT:R-GGA-5686924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Gallus gallus)
REACT:R-MMU-8856525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANGPTL8 binds ANGPTL3 (Mus musculus)
REACT:R-DME-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Drosophila melanogaster)
REACT:R-GGA-140769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VII -> factor VIIa (Gallus gallus)
REACT:R-XTR-982765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone forms dimers and oligomers (Xenopus tropicalis)
REACT:R-SSC-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Sus scrofa)
RHEA:51944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine = 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine
RHEA:51944	skos:prefLabel	"8-amino-8-demethylriboflavin N,N-dimethyltransferase"
RHEA:51944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-amino-8-demethylriboflavin N,N-dimethyltransferase"
REACT:R-RNO-879910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 is phosphorylated, activated (Rattus norvegicus)
REACT:R-DRE-8865613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Danio rerio)
RHEA:50977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D2(out) => prostaglandin D2(in)
REACT:R-SCE-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Saccharomyces cerevisiae)
GO:0097677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT family protein binding
GO:0097677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signal transducers and activators of transcription family protein binding
REACT:R-DRE-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Danio rerio)
GO:0016741	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methyltransferase activity
GO:0016741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring one-carbon groups"
GO:0016741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring one-carbon groups
GO:0016741	skos:prefLabel	"Transferring one-carbon groups"
REACT:R-SSC-8948219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3 binds Lysyl hydroxylated collagen propeptides (Sus scrofa)
RHEA:39195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetracosanoyl-CoA + H(+) + NADPH = (3R)-hydroxytetracosanoyl-CoA + NADP(+)
RHEA:69388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + carbamoyl phosphate = allantoate + H(+) + phosphate
REACT:R-HSA-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Homo sapiens)
RHEA:68413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate 5-semialdehyde + NADP(+) => 2 H(+) + L-glutamate + NADPH
REACT:R-SSC-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Sus scrofa)
REACT:R-XTR-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Xenopus tropicalis)
REACT:R-BTA-389463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteinase-activated receptors can bind thrombin (Bos taurus)
REACT:R-PFA-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Plasmodium falciparum)
RHEA:57981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside F1 + H(+) + UDP
REACT:R-MMU-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Mus musculus)
REACT:R-RNO-209960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diiodinated tyrosine can be deiodinated (Rattus norvegicus)
RHEA:51270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine => norbelladine + S-adenosyl-L-methionine
REACT:R-PFA-174203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-mediated degradation of Emi1 (Plasmodium falciparum)
REACT:R-CEL-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Caenorhabditis elegans)
GO:0004373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity
GO:0004373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-glycogen glucosyltransferase activity
GO:0004373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen (starch) synthase activity
GO:0004373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-glycogen glucosyltransferase activity
GO:0004373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity
GO:0004373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG-glycogen transglucosylase activity
GO:0004373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glycogen synthase activity
GO:0004373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG-glycogen synthetase activity
GO:0004373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen (starch) synthetase activity
REACT:R-DME-375790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Drosophila melanogaster)
REACT:R-MMU-1606789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses DS (Mus musculus)
REACT:R-SPO-8869606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NAR to yield NAMN (Schizosaccharomyces pombe)
REACT:R-DME-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Drosophila melanogaster)
REACT:R-MMU-163798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein Z to protein Z (Mus musculus)
REACT:R-CFA-5671970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CIT binds KIF14 and PRC1 (Canis familiaris)
REACT:R-MMU-195408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Mus musculus)
REACT:R-CEL-72185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA polyadenylation (Caenorhabditis elegans)
REACT:R-XTR-947535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Xenopus tropicalis)
RHEA:64783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-benzyl-L-cysteine <=> 2-aminoprop-2-enoate + benzylthiol
RHEA:48845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
RHEA:62795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + NADPH + O2 + 2 rubrofusarin B <=> 2 H2O + NADP(+) + nigerone
GO:0018720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenol kinase activity
REACT:R-DRE-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Danio rerio)
REACT:R-MMU-5579018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1(868-1441) binds PAX3(1-319) (Mus musculus)
RHEA:23945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP
REACT:R-DDI-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)
RHEA:32180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-dihydrodipicolinate + NAD(+) => dipicolinate + H(+) + NADH
REACT:R-RNO-5358340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoproteolytic cleavage of Hh precursors (Rattus norvegicus)
RHEA:33984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate => diphosphate + miltiradiene
REACT:R-HSA-77304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Homo sapiens)
REACT:R-MMU-376141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ABL with ROBO1:SLIT2 (Mus musculus)
RHEA:29709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-anhydro-N-acetyl-beta-muramate(out) => 1,6-anhydro-N-acetyl-beta-muramate(in)
REACT:R-GGA-5683384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UIMC1 and FAM175A bind DNA DSBs (Gallus gallus)
REACT:R-SSC-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Sus scrofa)
REACT:R-HSA-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Homo sapiens)
REACT:R-BTA-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Bos taurus)
REACT:R-CFA-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)
REACT:R-BTA-9027624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DHA to 7-HDHA (Bos taurus)
REACT:R-XTR-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Xenopus tropicalis)
REACT:R-DRE-2396370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds collagens II, III and V (Danio rerio)
RHEA:70254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine
REACT:R-DRE-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Danio rerio)
REACT:R-HSA-9710917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK fusion proteins bind PLCG1 (Homo sapiens)
RHEA:12035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(acyloxy)acyl derivative of bacterial toxin + H2O <=> 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
GO:0051742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSBQ methyltransferase activity
GO:0051742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity
REACT:R-BTA-71324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)
RHEA:58953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh1 + H(+) + UDP
RHEA:63104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ilicicolin A epoxide + NADPH + O2 = 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)
REACT:R-RNO-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Rattus norvegicus)
REACT:R-XTR-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Xenopus tropicalis)
REACT:R-BTA-994137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Bos taurus)
REACT:R-XTR-110248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 3-methyladenine by MPG glycosylase  (Xenopus tropicalis)
RHEA:47516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isochenodeoxycholate + NAD(+)
REACT:R-CEL-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Caenorhabditis elegans)
REACT:R-SCE-109639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the closed pre-initiation complex (Saccharomyces cerevisiae)
REACT:R-XTR-2681667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Xenopus tropicalis)
REACT:R-BTA-167433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta-gamma subunits rebind the alpha-GDP subunit (Bos taurus)
GO:0050524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methyl-CoM reductase activity
GO:0050524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme-B sulphoethylthiotransferase activity
GO:0050524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methyl coenzyme M reductase activity
GO:0050524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme-B sulfoethylthiotransferase activity
GO:0050524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-coenzyme-M reductase activity
GO:0050524	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity
REACT:R-SCE-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Saccharomyces cerevisiae)
RHEA:42780	skos:prefLabel	"18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase"
RHEA:42780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine
RHEA:42780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase"
REACT:R-GGA-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Gallus gallus)
REACT:R-SCE-3204303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRE11 binds cytosolic DNA (Saccharomyces cerevisiae)
RHEA:41754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O
GO:0047060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydropantoyl-lactone reductase (flavin) activity
GO:0047060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-pantoyllactone dehydrogenase (flavin) activity
GO:0047060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantolactone dehydrogenase (flavin) activity
GO:0047060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-pantolactone:acceptor oxidoreductase (flavin-containing)
GO:0047060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydropantolactone reductase (flavin) activity
REACT:R-RNO-5686900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 recruits DCLRE1C to ATM (Rattus norvegicus)
REACT:R-DRE-203565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)
RHEA:50618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-nonen-2-one + H(+) + NADPH => NADP(+) + nonan-2-one
REACT:R-CFA-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Canis familiaris)
REACT:R-HSA-8863013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 binds p25 (Homo sapiens)
REACT:R-DRE-141439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of activated MAD2 from kinetochores (Danio rerio)
REACT:R-SPO-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Schizosaccharomyces pombe)
RHEA:71845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tauroursodeoxycholate(in) => tauroursodeoxycholate(out)
REACT:R-DME-1977958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 forms heterodimers with ERBB3 (Drosophila melanogaster)
RHEA:37762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-BTA-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Bos taurus)
REACT:R-DRE-5682826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM11 (Danio rerio)
REACT:R-MMU-5628905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Mus musculus)
REACT:R-SPO-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Schizosaccharomyces pombe)
RHEA:52008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
REACT:R-RNO-203613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylation of eNOS (Rattus norvegicus)
REACT:R-SSC-514604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Sus scrofa)
RHEA:51778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycohumulone + diphosphate => 4-prenylphlorisobutanophenone + dimethylallyl diphosphate
RHEA:57441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] => 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
RHEA:31410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4,4'-diaponeurosporene + FAD + H(+) <=> all-trans-4,4'-diapolycopene + FADH2
REACT:R-DRE-1602488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by plasmin and trypsin (Danio rerio)
REACT:R-XTR-3781943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS:WNT complex is internalized for maturation into exosomes (Xenopus tropicalis)
REACT:R-MMU-4546385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO2 (Mus musculus)
REACT:R-SSC-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Sus scrofa)
REACT:R-CEL-156808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Caenorhabditis elegans)
EC:3.2.1.39	skos:altLabel	"laminarinase"
EC:3.2.1.39	skos:prefLabel	"glucan endo-1,3-beta-D-glucosidase"
EC:3.2.1.39	skos:altLabel	"endo-1,3-beta-glucanase"
EC:3.2.1.39	skos:altLabel	"(1->3)-beta-glucan endohydrolase"
EC:3.2.1.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan endo-1,3-beta-D-glucosidase"
REACT:R-MMU-8950387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX binds EBI3 (Mus musculus)
RHEA:55261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-DDI-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Dictyostelium discoideum)
REACT:R-RNO-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Rattus norvegicus)
GO:0010428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-CpNpG binding
GO:0047973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanidinoacetate = ADP + H(+) + phosphoguanidinoacetate
GO:0047973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycocyamine kinase activity
GO:0047973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:guanidinoacetate N-phosphotransferase activity
GO:0047973	skos:altLabel	"glycocyamine kinase"
GO:0047973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate kinase activity
GO:0047973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidoacetate kinase activity
GO:0047973	skos:prefLabel	"guanidinoacetate kinase"
GO:0047973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanidinoacetate kinase"
GO:0050640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-coenzyme A:isopenicillin N acyltransferase activity
GO:0050640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity
GO:0050640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isopenicillin N:acyl-CoA acyltransferase activity
GO:0050640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopenicillin-N acyltransferase activity
GO:0050640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopenicillin-N N-acyltransferase activity
GO:0050640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:isopenicillin N N-acyltransferase activity
REACT:R-BTA-8982162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Bos taurus)
RHEA:28906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(in) + H(+)(in) <=> D-alanine(out) + H(+)(out)
RHEA:42196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-2025723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the N-glycan precursor (Danio rerio)
REACT:R-RNO-70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Rattus norvegicus)
REACT:R-RNO-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Rattus norvegicus)
REACT:R-SSC-390593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Sus scrofa)
RHEA:48319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b <=> a ganglioside GD1alpha + CMP + H(+)
RHEA:16819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-2-dehydro-D-gluconate + H(+) + NADPH => 6-phospho-D-gluconate + NADP(+)
RHEA:68727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-9011543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCA binds PDK2 (Rattus norvegicus)
REACT:R-MMU-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Mus musculus)
RHEA:62437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lyxonate => 2-dehydro-3-deoxy-L-arabinonate + H2O
RHEA:12851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[myosin light chain] + phosphate => H2O + O-phospho-L-seryl-[myosin light chain]
RHEA:25483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate
REACT:R-DDI-9605644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Dictyostelium discoideum)
RHEA:67237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycophenolyl-CoA + propanoyl-CoA => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA
REACT:R-PFA-8865182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7A hydrolyses K11diUb (Plasmodium falciparum)
GO:0030792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylarsonite methyltransferase activity
RHEA:69977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:56915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) <=> (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH
REACT:R-DME-8853793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET complexes bind GRB2 (Drosophila melanogaster)
REACT:R-XTR-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Xenopus tropicalis)
RHEA:25191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + glycolate + H(+) => chloroacetate + H2O
RHEA:48724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin B + H(+) + H2O = 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide
GO:0047211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADPglucose:protein glucosyltransferase activity
GO:0047211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-glucose:protein 4-alpha-D-glucosyltransferase activity
GO:0047211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4alpha-glucan-protein synthase (ADP-forming) activity
GO:0047211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADPglucose:protein 4-alpha-D-glucosyltransferase activity
GO:0047211	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphoglucose-protein glucosyltransferase activity
GO:0047211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,4-glucan-protein synthase (ADP-forming) activity
RHEA:34041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'-oxoparomamine + L-glutamate => 2-oxoglutarate + neamine
REACT:R-BTA-5423672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)
REACT:R-HSA-373722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds CASK (Homo sapiens)
REACT:R-DRE-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Danio rerio)
REACT:R-HSA-6783492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met) (Homo sapiens)
REACT:R-BTA-171087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR [endosome membrane] => LDLR [plasma membrane] (Bos taurus)
REACT:R-RNO-350058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL NCOR corepressor complex (Rattus norvegicus)
RHEA:36183	skos:altLabel	"cholinephosphotransferase"
RHEA:36183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:36183	skos:prefLabel	"diacylglycerol cholinephosphotransferase"
RHEA:36183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diacylglycerol cholinephosphotransferase"
RHEA:36183	skos:altLabel	"alkylacylglycerol cholinephosphotransferase"
RHEA:36183	skos:altLabel	"1-alkyl-2-acetylglycerol cholinephosphotransferase"
RHEA:36183	skos:altLabel	"phosphorylcholine--glyceride transferase"
REACT:R-CFA-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Canis familiaris)
REACT:R-HSA-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Homo sapiens)
RHEA:33100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + spermine => CoA + H(+) + N(1)-acetylspermine
REACT:R-HSA-5654615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:pFRS binds GRB2:SOS1 (Homo sapiens)
REACT:R-DRE-9701485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds JAK3 (Danio rerio)
REACT:R-SCE-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)
RHEA:67997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-1,2-dichloroethene + AH2 => A + chloride + chloroethene + H(+)
REACT:R-BTA-1604360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP14 (Bos taurus)
REACT:R-DRE-168140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Danio rerio)
REACT:R-CEL-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Caenorhabditis elegans)
GO:0050190	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoglucokinase (phosphorylating)
GO:0050190	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity
GO:0050190	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose-phosphate kinase activity
GO:0050190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglucokinase activity
GO:0050190	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-glucose-1-phosphate 6-phosphotransferase activity
REACT:R-MMU-5654709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
RHEA:31916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-maltose => ADP + alpha-maltose 1-phosphate + H(+)
RHEA:20979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary nitroalkane + H2O + O2 <=> an aldehyde + H(+) + H2O2 + nitrite
REACT:R-DME-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Drosophila melanogaster)
REACT:R-SPO-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Schizosaccharomyces pombe)
GO:0005216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ion channel activity
REACT:R-BTA-372480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Bos taurus)
REACT:R-CFA-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Canis familiaris)
REACT:R-DME-5251942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hikeshi binds HSP70s:ATP (Drosophila melanogaster)
RHEA:29536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
REACT:R-GGA-6814671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of late-endosome derived vesicles at the TGN (Gallus gallus)
REACT:R-RNO-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Rattus norvegicus)
RHEA:61154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]
RHEA:52866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose
RHEA:52902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate => 3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide
REACT:R-DDI-450358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Dictyostelium discoideum)
GO:0140934	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone deubiquitination
GO:0140934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone deubiquitinase activity
RHEA:46073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-CoA + H(+) + NADH => hexadecanoyl-CoA + NAD(+)
REACT:R-PFA-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Plasmodium falciparum)
RHEA:45325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine
REACT:R-SSC-6809325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Sus scrofa)
REACT:R-HSA-173626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1r (Homo sapiens)
REACT:R-MMU-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Mus musculus)
RHEA:63899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspulvinone E + hnu <=> isoaspulvinone E
RHEA:62560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + A + H2O = (4R)-perillyl alcohol + AH2
RHEA:36897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2
REACT:R-HSA-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Homo sapiens)
REACT:R-BTA-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Bos taurus)
RHEA:65681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine
REACT:R-DDI-9677917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA inhibitors bind MAOA:FAD (Dictyostelium discoideum)
GO:0034006	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amorphadiene synthase activity
GO:0034006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amorpha-4,11-diene synthase activity
GO:0034006	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity
REACT:R-BTA-202144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)
REACT:R-HSA-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Homo sapiens)
REACT:R-CFA-9688838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds STUB1 (Canis familiaris)
GO:0008775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyryl CoA:acetate CoA transferase activity
GO:0008775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetate coenzyme A-transferase activity
GO:0008775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:acetate CoA transferase activity
GO:0008775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:acetoacetate CoA transferase activity
GO:0008775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate CoA-transferase activity
GO:0008775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:acetate CoA-transferase activity
GO:0008775	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyryl coenzyme A transferase activity
EC:2.4.1.373	skos:prefLabel	"alpha-(1->2) branching sucrase"
EC:2.4.1.373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-(1->2) branching sucrase"
REACT:R-BTA-446877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is K63 poly-ubiquitinated (Bos taurus)
GO:0030882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid antigen binding
REACT:R-DDI-1605632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Both hexosaminidase A and B can cleave GalNAc from globoside (Dictyostelium discoideum)
REACT:R-SSC-936897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Sus scrofa)
REACT:R-HSA-9653514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17L2 deubiquitinates RCE1 (Homo sapiens)
RHEA:28360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-CoA + FADH2 => FAD + H(+) + tetradecanoyl-CoA
RHEA:47996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)
GO:0030354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melanin-concentrating hormone activity
GO:0016725	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on CH or CH2 groups, other acceptors
GO:0016725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on CH or CH2 groups
GO:0016725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on CH or CH2 groups"
GO:0016725	skos:prefLabel	"Acting on CH or CH2 groups"
REACT:R-CFA-9026003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Canis familiaris)
RHEA:17735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + pyruvate => acetylenedicarboxylate + H(+) + H2O
REACT:R-DME-450690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Drosophila melanogaster)
REACT:R-GGA-140664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)
RHEA:13036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galactose 6-phosphate <=> keto-D-tagatose 6-phosphate
RHEA:53524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
RHEA:32194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9683624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA2 is translated to Spike (Homo sapiens)
REACT:R-GGA-5218815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds NCK (Gallus gallus)
REACT:R-SCE-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Saccharomyces cerevisiae)
REACT:R-GGA-4656914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKBIA with SUMO1 (Gallus gallus)
RHEA:15142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol + H2O + 4 oxidized [azurin] => 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]
RHEA:62676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide = 6-thio-IMP + 7,8-dihydrofolate + H2O
REACT:R-XTR-2730833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TEC kinases by p-SYK (Xenopus tropicalis)
RHEA:65622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine => hexadecanoyl-CoA + sphinga-(4E,8E)-dienine
REACT:R-HSA-193537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)
GO:0051698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	saccharopine oxidase activity
GO:0051698	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	SAX activity
REACT:R-XTR-1168643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCP ubiquitinylates IkB (Xenopus tropicalis)
RHEA:72496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + prostaglandin E2(out) => glutarate(out) + prostaglandin E2(in)
REACT:R-SSC-140840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Sus scrofa)
REACT:R-BTA-3371353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble TNF-α binds TNFR1 (Bos taurus)
RHEA:10398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H(+) + NADH + NH4(+) => an L-alpha-amino acid + H2O + NAD(+)
GO:0033788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R,3S)-catechin:NADP+ 4-oxidoreductase activity
GO:0033788	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	leucocyanidin reductase activity
GO:0033788	skos:prefLabel	"leucoanthocyanidin reductase"
GO:0033788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leucoanthocyanidin reductase"
GO:0033788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucoanthocyanidin reductase activity
GO:0033788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-catechin + H2O + NADP(+) = (2R,3S,4S)-leucocyanidin + H(+) + NADPH
GO:0033788	skos:altLabel	"leucocyanidin reductase"
REACT:R-HSA-6800042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the IGFBP3 gene (Homo sapiens)
REACT:R-PFA-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-CFA-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Canis familiaris)
REACT:R-CFA-5099899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD4 (Canis familiaris)
REACT:R-HSA-6799246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates TP53 (Homo sapiens)
REACT:R-DME-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Drosophila melanogaster)
REACT:R-DRE-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Danio rerio)
RHEA:57761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
RHEA:55651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + validoxylamine A <=> CO2 + H(+) + succinate + validoxylamine B
EC:1.97.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other oxidoreductases"
EC:1.97.1.-	skos:prefLabel	"Other oxidoreductases"
REACT:R-XTR-4086223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IX binds integrin alpha11beta1 (Xenopus tropicalis)
RHEA:28088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate => 2 H2O2 + Reactive Blue 5
REACT:R-HSA-1470012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus (Homo sapiens)
REACT:R-XTR-549241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-CEL-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)
REACT:R-HSA-178189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
GO:0102909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate reductase activity (NADH-dependent)
REACT:R-XTR-9018785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds GTP (Xenopus tropicalis)
RHEA:17438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate => (2E,4E)-2,4-dichloromuconate + H(+)
REACT:R-DRE-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Danio rerio)
GO:0050377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)
GO:0050377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-glucose oxidoreductase activity
GO:0050377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-glucose 4,6-dehydratase"
GO:0050377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose 4,6-dehydratase activity
GO:0050377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose = H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose
GO:0050377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose 4,6-dehydratase activity
GO:0050377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose 4,6-hydro-lyase activity
GO:0050377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose 4,6-hydro-lyase activity
GO:0050377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-glucose-4,6-hydrolyase activity
GO:0050377	skos:prefLabel	"UDP-glucose 4,6-dehydratase"
REACT:R-MMU-2059926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPHP4 protein binds LATS proteins (Mus musculus)
REACT:R-DDI-1169406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host proteins (Dictyostelium discoideum)
RHEA:67729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA(n) + dZTP => diphosphate + DNA(n)-Z
RHEA:28874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructuronate(in) + H(+)(in) <=> D-fructuronate(out) + H(+)(out)
REACT:R-MMU-5218841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)
REACT:R-CEL-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Caenorhabditis elegans)
RHEA:50088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + 2 phosphate(in) => ATP + H2O + phosphate(out)
RHEA:14046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-carboxyvinyl carboxyphosphonate + H(+) => 3-(hydrohydroxyphosphoryl)pyruvate + CO2
REACT:R-HSA-4568737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-1 transcription factor binds IL1A promoter (Homo sapiens)
REACT:R-XTR-1112514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK activation (Xenopus tropicalis)
RHEA:62163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate <=> N-(9Z-octadecenoyl) ethanolamine + phosphate
REACT:R-GGA-170861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimeric TGF-beta-1 binds to the receptor (Gallus gallus)
REACT:R-MMU-73945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAS-mediated dimerization of procaspase-8 (Mus musculus)
GO:0102301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-linolenate elongase activity
REACT:R-XTR-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Xenopus tropicalis)
GO:0033448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine tRNA
GO:0033448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGG codon-amino acid adaptor activity
REACT:R-RNO-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Rattus norvegicus)
REACT:R-CFA-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Canis familiaris)
RHEA:15978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelonitrile => 4-hydroxybenzaldehyde + hydrogen cyanide
RHEA:61839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol + UDP-alpha-D-glucose <=> ergosteryl 3-beta-D-glucoside + H(+) + UDP
RHEA:50240	skos:prefLabel	"hyaluronate lyase"
RHEA:50240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hyaluronate lyase"
RHEA:50240	skos:altLabel	"mucinase"
RHEA:50240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[hyaluronan](n) = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O
RHEA:50240	skos:altLabel	"hyaluronidase"
RHEA:50240	skos:altLabel	"spreading factor"
REACT:R-MMU-3232162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates MITF with SUMO1 (Mus musculus)
REACT:R-HSA-8987236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Homo sapiens)
REACT:R-RNO-4088218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetrastatin binds integrin alphaVbeta3 (Rattus norvegicus)
RHEA:44692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + hexadecasphinganine = CoA + H(+) + N-acylhexadecasphinganine
REACT:R-HSA-389978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-tubulin:GTP + Cofactor E ->  alpha-tubulin:GTP:Cofactor E (Homo sapiens)
RHEA:45696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(acetyl)-sphing-4-enine-1-phosphate(in) = N-(acetyl)-sphing-4-enine-1-phosphate(out)
REACT:R-CEL-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Caenorhabditis elegans)
REACT:R-HSA-181567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botC LC cleaves target cell STX1 (Homo sapiens)
REACT:R-BTA-176250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR-ATRIP to the RPA-ssDNA complex (Bos taurus)
RHEA:13159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH => (R)-glycerate + CO2 + NADP(+)
REACT:R-XTR-9008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylation (Xenopus tropicalis)
REACT:R-XTR-1168633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB translocates from the cytosol to the nucleus (Xenopus tropicalis)
RHEA:11270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + NH4(+) + pyruvate => D-cysteine + H2O
REACT:R-BTA-5579023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA2(869-1464) binds KAT6A(1-1118) (Bos taurus)
REACT:R-GGA-375140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds promyogenic cadherins (Gallus gallus)
REACT:R-MMU-2046084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Mus musculus)
REACT:R-MMU-9726509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 binds fludrocortisone (Mus musculus)
REACT:R-XTR-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Xenopus tropicalis)
RHEA:37243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA
RHEA:63695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol glucuronate acceptor + UDP-alpha-D-glucuronate <=> a beta-D-glucuronoside + H(+) + UDP
RHEA:69055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 <=> 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)
REACT:R-CEL-6784763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)
REACT:R-XTR-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Xenopus tropicalis)
REACT:R-MMU-6799196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Mus musculus)
REACT:R-DRE-2395869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)
RHEA:24322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-1604690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MMP9 intermediate form by MMPs (Mus musculus)
REACT:R-MMU-3465459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Mus musculus)
REACT:R-HSA-9625904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine (Homo sapiens)
RHEA:65982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tachysterol 3 => hnu + previtamin D3
REACT:R-RNO-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Rattus norvegicus)
RHEA:58078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoate + glycerol + H(+) => 1-(11Z-eicosenoyl)-glycerol + H2O
REACT:R-DRE-74177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Danio rerio)
REACT:R-HSA-981658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds C4BP (Homo sapiens)
RHEA:30479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-2076611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3STs sulfate GlcN at C3 in heparan sulfate (Bos taurus)
RHEA:19468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + 2 nitric oxide + 2 O2 <=> H(+) + NADP(+) + 2 nitrate
RHEA:55944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloroethanol + 2 Fe(III)-[cytochrome c] = chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-DME-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)
RHEA:26075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + H(+) + UDP => H2O + UDP-alpha-D-glucuronate
REACT:R-HSA-9707690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 binds MAFK (Homo sapiens)
REACT:R-HSA-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Homo sapiens)
RHEA:23029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] => acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]
REACT:R-HSA-189467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic COPRO3 translocates to mitochondrial intermembrane space (Homo sapiens)
REACT:R-RNO-376122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM/DSCAML1 homodimerization (Rattus norvegicus)
RHEA:56378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+) => 3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2
REACT:R-HSA-8944242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVII (Homo sapiens)
GO:0018555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenanthrene dioxygenase activity
RHEA:67604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl-dAMP
REACT:R-DRE-4086036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate NRIP1 with SUMO1 (Danio rerio)
REACT:R-HSA-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)
RHEA:32361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+) => 1D-myo-inositol 1,4,5-trisphosphate + 2 ATP
GO:1990042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol dehydrogenase activity, NAD or NADP as acceptor
GO:1990042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol dehydrogenase [NAD(P)+] activity
RHEA:64109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
REACT:R-XTR-9688838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds STUB1 (Xenopus tropicalis)
RHEA:30861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIDP + H(+) + phosphate => dITP + H2O
RHEA:50096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-517705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S318,221-HuR binds mRNA (Gallus gallus)
RHEA:35761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-2730843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LAT by p-SYK (Rattus norvegicus)
RHEA:72763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A10 + malonyl-CoA = anthocyanin A11 + CoA
REACT:R-RNO-209536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IkB is ubiquitinated and degraded (Rattus norvegicus)
REACT:R-DRE-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Danio rerio)
REACT:R-DRE-192061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP46A1 24-hydroxylates CHOL (Danio rerio)
RHEA:58546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-tetradecanoylglycine + O2
REACT:R-SCE-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Saccharomyces cerevisiae)
RHEA:39187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydocosanoyl-CoA = (2E)-docosenoyl-CoA + H2O
REACT:R-HSA-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Homo sapiens)
RHEA:72456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(out) + 3 H(+)(out) => fumarate(in) + 3 H(+)(in)
RHEA:61767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside E + UDP
REACT:R-CFA-888577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GABA by GAD2 (Canis familiaris)
REACT:R-RNO-352268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Satb1 (Rattus norvegicus)
REACT:R-RNO-9023627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)
REACT:R-DRE-9668902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18-RFC(7s) complex (Danio rerio)
RHEA:47597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP
REACT:R-SCE-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)
RHEA:43977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + NADPH + O2 => 14-hydroxyhexadecanoate + H2O + NADP(+)
REACT:R-CFA-110359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Canis familiaris)
RHEA:59608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-L-lysine + H2O = beta-alanine + L-lysine
RHEA:57613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH => 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)
REACT:R-MMU-4570554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO1 (Mus musculus)
GO:0047350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronate-1-phosphate uridylyltransferase activity
GO:0047350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronate pyrophosphorylase activity
GO:0047350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP:glucuronate-1-phosphate uridylyltransferase activity
GO:0047350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucuronic pyrophosphorylase activity
GO:0047350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronic acid pyrophosphorylase activity
GO:0047350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity
GO:0047350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-glucuronic acid pyrophosphorylase activity
REACT:R-MMU-420214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The adrenomedullin receptor can bind adrenomedullin and intermedin (Mus musculus)
REACT:R-RNO-389758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
REACT:R-CFA-6785898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R binds JAK2 (Canis familiaris)
REACT:R-BTA-114256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS:APAF1 binds procaspase-9 (Bos taurus)
GO:0004998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferrin receptor activity
REACT:R-CFA-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Canis familiaris)
RHEA:24762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+) => H(+) + L-dopa + NADH
REACT:R-HSA-8877311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB31 GEFs exchange GTP for GDP on RAB31 (Homo sapiens)
REACT:R-DRE-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)
RHEA:41681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) => a 2-all-trans-polyprenylphenol + CO2
REACT:R-CFA-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Canis familiaris)
REACT:R-HSA-174374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)
RHEA:23018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + H(+) + NADPH => (2R,3S,4S)-3,4-leucopelargonidin + NADP(+)
REACT:R-CFA-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Canis familiaris)
RHEA:29141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + H2O + menaquinone-8 + nitrite => 2 H(+)(in) + menaquinol-8 + nitrate
REACT:R-RNO-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
REACT:R-RNO-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Rattus norvegicus)
REACT:R-MMU-5626227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CP110 and CEP97 dissociate from the centriole (Mus musculus)
REACT:R-SSC-174445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap on the C-strand (Sus scrofa)
REACT:R-DRE-9725206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds FCERI (Danio rerio)
RHEA:46246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2
REACT:R-GGA-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Gallus gallus)
RHEA:36874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA
REACT:R-SSC-5229273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCN2:2,5DHBA binds Fe3+ (Sus scrofa)
RHEA:40133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + CoA + H(+) => (9Z)-hexadecenoyl-CoA + H2O
REACT:R-SSC-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Sus scrofa)
GO:0003908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0003908	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	O6-alkylguanine-DNA alkyltransferase
GO:0003908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGMT
GO:0003908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylated-DNA-protein-cysteine S-methyltransferase activity
GO:0003908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity
GO:0003908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-6-methylguanine-DNA-alkyltransferase activity
GO:0003908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity
GO:0003908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-O-methylguanine-DNA methyltransferase activity
GO:0030986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMW kininogen binding
GO:0030986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low molecular weight kininogen binding
GO:0030986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LK binding
REACT:R-HSA-1181352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEFTY binds NODAL (Homo sapiens)
RHEA:49595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutanoyl-CoA <=> (3S)-3-hydroxybutanoyl-CoA
RHEA:56706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2
REACT:R-HSA-9755304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUL1 ubiquitinates UBXN7 (Homo sapiens)
REACT:R-XTR-5620914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF4:GTP binds VxPx-motifs of membrane proteins (Xenopus tropicalis)
RHEA:18187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-dehydroadenosine + H2O2 => adenosine + O2
RHEA:21321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-sorbitol => AH2 + keto-L-sorbose
GO:0022881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine PTS transporter activity
GO:0022881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity
GO:0102563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C monooxygenase activity
RHEA:24509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin E2
REACT:R-HSA-202216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 (Homo sapiens)
REACT:R-SSC-379044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gs-activating GPCR acts as a GEF for Gs (Sus scrofa)
RHEA:25493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => (-)-beta-phellandrene + diphosphate
REACT:R-BTA-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Bos taurus)
RHEA:51895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetylcadaverine <=> acetate + cadaverine
REACT:R-CFA-5683986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)
RHEA:21259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphoshikimate + phosphoenolpyruvate <=> 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate
REACT:R-RNO-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Rattus norvegicus)
RHEA:71447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(in) + Na(+)(in) = D-alanine(out) + Na(+)(out)
REACT:R-HSA-5662620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 binds cadmium (Homo sapiens)
REACT:R-CFA-5654416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:pFRS binds GRB2:SOS1 (Canis familiaris)
REACT:R-BTA-5638016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2:ARL3:GDP:UNC119B dissociates (Bos taurus)
REACT:R-CFA-173542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 ubiquitinates SMAD2 (Canis familiaris)
RHEA:42841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH => 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)
RHEA:33192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA
RHEA:34305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate + NH4(+) => L-lysine
RHEA:45433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate
GO:0031752	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D5 dopamine receptor ligand
GO:0031752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D5 dopamine receptor binding
GO:0031752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D1B dopamine receptor binding
REACT:R-DME-9684627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds CYSLTR1 antagonists (Drosophila melanogaster)
REACT:R-RNO-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Rattus norvegicus)
RHEA:47892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
RHEA:20123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-glutaminyl-tRNA(Gln) => ATP + L-glutamine + tRNA(Gln)
RHEA:50257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] => acetyl-[ACP] + CO2
RHEA:43517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-5-formylfuran + H2O => 2-carboxy-5-(dihydroxymethyl)furan
REACT:R-BTA-426209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG activation of TRPC channels (Bos taurus)
RHEA:22678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + H2O + NADP(+) => chlorophyllide a + H(+) + NADPH + O2
REACT:R-PFA-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Plasmodium falciparum)
REACT:R-HSA-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Homo sapiens)
RHEA:38092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocotrienol + S-adenosyl-L-methionine => beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine
RHEA:30878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + D-glutamate
REACT:R-DME-114548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Drosophila melanogaster)
RHEA:20523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + H(+) + NADH => (R)-3-hydroxybutanoate + NAD(+)
RHEA:61465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in mRNA + S-adenosyl-L-methionine => a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:58219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydroserpentine <=> AH2 + serpentine
RHEA:20570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine => L-ornithine + urea
GO:0031859	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	platelet activating factor receptor ligand
GO:0031859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	platelet activating factor receptor binding
REACT:R-DDI-8855490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoperoxidase (LPO) produces OSCN- (Dictyostelium discoideum)
RHEA:17742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + shikimate => 3-dehydroshikimate + H(+) + NADH
RHEA:67023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SPO-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Schizosaccharomyces pombe)
RHEA:35129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-D-glutamate(in) => L-alanyl-D-glutamate(out)
RHEA:17813	skos:altLabel	"altronate oxidoreductase"
RHEA:17813	skos:altLabel	"altronate dehydrogenase"
RHEA:17813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH
RHEA:17813	skos:altLabel	"Tagaturonate dehydrogenase"
RHEA:17813	skos:prefLabel	"tagaturonate reductase"
RHEA:17813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tagaturonate reductase"
RHEA:17813	skos:altLabel	"altronic oxidoreductase"
REACT:R-BTA-4086132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin phosphoprotein binds integrin alphaVbeta1 (Bos taurus)
RHEA:66022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen]
REACT:R-CFA-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Canis familiaris)
REACT:R-RNO-196350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Rattus norvegicus)
GO:0102385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	patchoulol synthase activity
RHEA:51885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline betaine => D-proline betaine
REACT:R-XTR-1362465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GHR (Xenopus tropicalis)
REACT:R-GGA-508162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Gallus gallus)
REACT:R-XTR-1964501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Xenopus tropicalis)
REACT:R-MMU-8944233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIX (Mus musculus)
REACT:R-GGA-5676589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANKL,sRANKL trimer binds RANK (Gallus gallus)
RHEA:30808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH
REACT:R-MMU-140978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex binds FADD (Mus musculus)
REACT:R-HSA-194023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2,HSD11B1 dimer oxidise CORT to COR (Homo sapiens)
REACT:R-CEL-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Caenorhabditis elegans)
RHEA:49163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-193679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-secretase cleaves the p75NTR extracellular domain (Bos taurus)
RHEA:59214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP
REACT:R-DDI-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Dictyostelium discoideum)
RHEA:25184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + putrescine <=> CoA + H(+) + N-acetylputrescine
RHEA:40807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine
REACT:R-HSA-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Homo sapiens)
RHEA:22456	skos:prefLabel	"creatinase"
RHEA:22456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"creatinase"
RHEA:22456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + H2O = sarcosine + urea
RHEA:22456	skos:altLabel	"creatine amidinohydrolase"
RHEA:39535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA = (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O
GO:0099589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serotonin receptor activity
RHEA:23117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + CoA => 4-hydroxybenzoyl-CoA + AMP + diphosphate
REACT:R-HSA-9694525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	M protein gets N-glycosylated (Homo sapiens)
REACT:R-DRE-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Danio rerio)
REACT:R-XTR-5693593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop extension by DNA polymerases (Xenopus tropicalis)
RHEA:30724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 2 ADP + H(+) + NH4(+) + 2 phosphate => AH2 + 2 ATP + H2O + hydroxylamine
RHEA:32223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate
REACT:R-GGA-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Gallus gallus)
GO:0046332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD binding
REACT:R-HSA-9020249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6 (Homo sapiens)
REACT:R-DRE-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Danio rerio)
REACT:R-CFA-1168642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)
REACT:R-RNO-9733960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids dissociate from ALB (Rattus norvegicus)
REACT:R-MMU-6798474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Zn2+ (Mus musculus)
REACT:R-SSC-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Sus scrofa)
RHEA:37283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-histidine = L-alanine + L-histidine
REACT:R-GGA-191656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Closure of gap junction (Gallus gallus)
REACT:R-RNO-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
GO:0036320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-factor receptor activity
GO:0036320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mating-type P-factor pheromone receptor activity
GO:0036320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-factor mating pheromone receptor activity
REACT:R-SCE-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Saccharomyces cerevisiae)
RHEA:54386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5alpha-steroid + NADP(+)
RHEA:27482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-8931858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Xenopus tropicalis)
REACT:R-CEL-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Caenorhabditis elegans)
REACT:R-MMU-5668545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK autophosphorylates on T559 (Mus musculus)
REACT:R-BTA-3222020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUAK1 phosphorylates TP53 (Bos taurus)
REACT:R-BTA-159733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor X to factor X (Bos taurus)
RHEA:68179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N-geranyl-L-glutamate + O2 <=> CO2 + dainate A + H2O + succinate
RHEA:12628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose <=> D-glucose + sinapoyl (S)-malate
GO:0001641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	group II metabotropic glutamate receptor activity
REACT:R-HSA-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Homo sapiens)
REACT:R-RNO-6786789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer binds FLT3 (Rattus norvegicus)
RHEA:49806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FMNH2 + O2
RHEA:17377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)
REACT:R-BTA-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Bos taurus)
RHEA:35326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH
REACT:R-HSA-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Homo sapiens)
REACT:R-CEL-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Caenorhabditis elegans)
RHEA:63679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH
REACT:R-CEL-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Caenorhabditis elegans)
RHEA:63393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + Fe(II)-heme o + H2O => AH2 + Fe(II)-heme i
RHEA:67806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2
REACT:R-MMU-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Mus musculus)
REACT:R-HSA-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Homo sapiens)
RHEA:19569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase"
RHEA:19569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:19569	skos:prefLabel	"tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase"
RHEA:19569	skos:altLabel	"tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase"
REACT:R-RNO-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Rattus norvegicus)
RHEA:52549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonate + NAD(+) => 2-dehydro-L-erythronate + H(+) + NADH
REACT:R-DRE-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Danio rerio)
RHEA:35044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(4-aminobenzoyl)-L-glutamate(in) => N-(4-aminobenzoyl)-L-glutamate(out)
REACT:R-BTA-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Bos taurus)
REACT:R-DRE-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Danio rerio)
RHEA:36768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine
REACT:R-MMU-6799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates TP53 (Mus musculus)
REACT:R-SSC-8849094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RASA1 (Sus scrofa)
RHEA:24189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) => 1,2-dihydroxydibenzothiophene + H(+) + NADH
RHEA:18540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + salicylaldehyde <=> 2 H(+) + NADH + salicylate
REACT:R-XTR-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)
REACT:R-SSC-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Sus scrofa)
RHEA:43575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-arginine + H2O <=> 5-guanidino-2-oxopentanoate + AH2 + NH4(+)
RHEA:23401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxykynurenate + O2 => 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)
GO:0015148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose transmembrane transporter activity
REACT:R-SSC-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Sus scrofa)
REACT:R-XTR-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)
RHEA:19553	skos:altLabel	"TNase"
RHEA:19553	skos:prefLabel	"tryptophanase"
RHEA:19553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tryptophan = indole + NH4(+) + pyruvate
RHEA:19553	skos:altLabel	"L-tryptophan indole-lyase"
RHEA:19553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophanase"
REACT:R-BTA-73797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAICAR => IMP + H2O (Bos taurus)
REACT:R-SSC-8957241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP73 tetramer translocates to the nucleus (Sus scrofa)
GO:0050152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	omega-amidodicarboxylate amidohydrolase activity
GO:0050152	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-keto acid-omega-amidase activity
GO:0050152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	w-amidase activity
GO:0050152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	omega-amidase activity
REACT:R-CFA-165718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylation of RPS6KB1 (S6K) (Canis familiaris)
RHEA:50744	skos:prefLabel	"glyphosate oxidoreductase"
RHEA:50744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glyphosate + O2 = 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)
RHEA:50744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyphosate oxidoreductase"
REACT:R-GGA-8849353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Gallus gallus)
RHEA:53853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate + NAD(+) => 7-oxo-glycodeoxycholate + H(+) + NADH
RHEA:33376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + H(+) + NADPH => a 1-acyl-sn-glycero-3-phosphate + NADP(+)
REACT:R-BTA-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Bos taurus)
RHEA:26022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O <=> beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate
RHEA:40491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)
REACT:R-HSA-9655046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of FXII variant by KLKB1 (Homo sapiens)
RHEA:38904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin(in) + ATP + H2O => a sphingomyelin(out) + ADP + H(+) + phosphate
REACT:R-HSA-9749607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Homo sapiens)
REACT:R-BTA-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Bos taurus)
REACT:R-CFA-5610737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH bind and ubiquitnate GLI1 (Canis familiaris)
REACT:R-SPO-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Schizosaccharomyces pombe)
GO:0016980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinase activity
GO:0016980	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	creatine amidinohydrolase activity
REACT:R-MMU-9612501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates CREB1 (Mus musculus)
RHEA:55492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:32980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a fatty acid + H(+) + sn-glycero-3-phospho-L-serine
REACT:R-HSA-2395784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent CMs transform into mature CMs (Homo sapiens)
RHEA:50149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid ethyl ester + H2O => a fatty acid + ethanol + H(+)
REACT:R-XTR-432952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP180 interacts intracellularly with plectin and integrin beta4 (Xenopus tropicalis)
RHEA:28826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-galactonate(in) <=> H(+)(out) + L-galactonate(out)
RHEA:17523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate => ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln)
REACT:R-DME-5362448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh C-terminal fragments are degraded by the proteasome (Drosophila melanogaster)
RHEA:53661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate
RHEA:29452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphonate => H2 + phosphate
RHEA:20911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP
RHEA:22998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-dehydroascorbate => H2O2 + L-ascorbate
RHEA:12431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH <=> benzene-1,2,4-triol + NAD(+)
REACT:R-GGA-5218820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src kinases phosphorylate VAV (Gallus gallus)
REACT:R-RNO-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Rattus norvegicus)
REACT:R-DRE-2022141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolysyl oxidase activation (Danio rerio)
REACT:R-RNO-2534346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAM1 Binds Hyaluronic Acid (Rattus norvegicus)
RHEA:68981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tauroursodeoxycholate => 7-oxotaurolithocholate + H(+) + NADPH
REACT:R-CFA-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Canis familiaris)
REACT:R-BTA-3134954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX9 binds DNA (Bos taurus)
RHEA:43674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol
RHEA:45160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H(+) = acetaldehyde + CO2
RHEA:64942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + H(+) + phosphate => dGDP + H2O
RHEA:22663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP + holo-[ACP] <=> a fatty acyl-[ACP] + AMP + diphosphate
RHEA:28625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol => (-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase]
GO:0047950	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:oxygen oxidoreductase activity
GO:0047950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione oxidase activity
REACT:R-HSA-8870628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FOXO3 translocates to the nucleus (Homo sapiens)
RHEA:66074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine
RHEA:43975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)
EC:3.5.1.117	skos:altLabel	"nylon hydrolase"
EC:3.5.1.117	skos:altLabel	"nylon-oligomer hydrolase"
EC:3.5.1.117	skos:prefLabel	"6-aminohexanoate-oligomer endohydrolase"
EC:3.5.1.117	skos:altLabel	"endo-type 6-aminohexanoate oligomer hydrolase"
EC:3.5.1.117	skos:altLabel	"nylon-6 hydrolase"
EC:3.5.1.117	skos:altLabel	"6-aminohexanoate oligomer hydrolase"
EC:3.5.1.117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-aminohexanoate-oligomer endohydrolase"
REACT:R-DME-5362386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Hh (Drosophila melanogaster)
REACT:R-DDI-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Dictyostelium discoideum)
GO:0030290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Homo sapiens)
GO:0030290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid activator protein activity
GO:0030290	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	saposin
RHEA:61739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviolmonoside + UDP-alpha-D-glucose <=> rubusoside + UDP
REACT:R-GGA-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Gallus gallus)
RHEA:34230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-nitrosalicylate + O2 <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite
GO:0004417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyethylthiazole kinase activity
GO:0004417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity
GO:0004417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyethylthiazole kinase (phosphorylating)
GO:0004417	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity
GO:0047970	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanidinoacetate amidinohydrolase activity
GO:0047970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetase activity
GO:0047970	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycocyaminase activity
REACT:R-BTA-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Bos taurus)
REACT:R-CFA-9634584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Canis familiaris)
RHEA:70366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanurate + H2O <=> 1-carboxybiuret + H(+)
REACT:R-MMU-909721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ISGF3 complex to nucleus (Mus musculus)
REACT:R-HSA-112125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative dealkylation of 1-EtA damaged DNA by ABH3 (Homo sapiens)
RHEA:53695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O <=> H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine
GO:0050811	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diazepam binding inhibitor activity
GO:0050811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate receptor binding
GO:0050811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyrate receptor binding
GO:0050811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid receptor binding
GO:0050811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA receptor binding
REACT:R-BTA-9014454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG translocates to the ER membrane (Bos taurus)
RHEA:63142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine + tetracosanoate => H2O + N-tetracosanoyl-taurine
RHEA:60314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine
REACT:R-RNO-390641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA1A,B,D bind ADR,NAd (Rattus norvegicus)
REACT:R-SSC-191784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA Cap hypermethylation (Sus scrofa)
REACT:R-HSA-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Homo sapiens)
RHEA:36080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine
RHEA:52711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H2O <=> D-ribose 5-phosphate + guanine
REACT:R-XTR-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Xenopus tropicalis)
GO:0047738	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cellobiose:phosphate alpha-D-glucosyltransferase activity
GO:0047738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellobiose phosphorylase activity
GO:0047738	skos:prefLabel	"cellobiose phosphorylase"
GO:0047738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose
GO:0047738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cellobiose phosphorylase"
RHEA:45961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:69340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-prop-1-en-1-SO-peroxol = (Z)-propanethial S-oxide
REACT:R-XTR-201445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Xenopus tropicalis)
REACT:R-BTA-1112510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6ST is tyrosine phosphorylated (Bos taurus)
RHEA:59138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine => ATP + citrate + D-ornithine
REACT:R-SSC-2022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to heparan (Sus scrofa)
GO:0103035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)H:methyl-1,4-benzoquinone oxidoreductase activity
RHEA:20078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(18) in tRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine
GO:0045140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol phosphoceramide synthase activity
GO:0045140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IPC synthase activity
REACT:R-DRE-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Danio rerio)
RHEA:49887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-2179413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC-alpha  activate MMP3 (Mus musculus)
REACT:R-CEL-2029473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Branching and elongation of mother and daughter filaments (Caenorhabditis elegans)
RHEA:27424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (3E,6E)-alpha-farnesene + diphosphate
GO:0008036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diuretic hormone receptor activity
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-tubulin N-acetyltransferase activity
GO:0019799	skos:altLabel	"alpha-tubulin acetyltransferase"
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-tubulin N-acetyltransferase"
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-tubulin acetylase activity
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-tubulin acetyltransferase activity
GO:0019799	skos:altLabel	"alpha-tubulin acetylase"
GO:0019799	skos:altLabel	"TAT"
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin N-acetyltransferase activity
GO:0019799	skos:prefLabel	"alpha-tubulin N-acetyltransferase"
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tubulin acetyltransferase activity
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]
GO:0019799	skos:altLabel	"tubulin acetyltransferase"
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TAT activity
GO:0019799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity
GO:0019799	skos:altLabel	"tubulin N-acetyltransferase"
REACT:R-GGA-9684068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD binds cardiac glycosides (Gallus gallus)
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neuraminic aldolase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neuraminate aldolase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate pyruvate-lyase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminic aldolase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NANA lyase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NPL
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialic acid aldolase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylneuraminate pyruvate-lyase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminic lyase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminic acid aldolase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylneuraminate lyase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	neuraminic acid aldolase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialic aldolase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate aldolase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminic acid lyase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NALase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminate lyase activity
GO:0008747	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialate lyase activity
REACT:R-SSC-8873946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD3 deubiquitinates PTEN (Sus scrofa)
RHEA:67473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + succinyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine
RHEA:33228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + H(+) => 4-hydroxystyrene + CO2
RHEA:62723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 NADPH + 3 O2 + probetaenone I <=> betaenone B + 3 H2O + 3 NADP(+)
GO:0033721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-dependent aldehyde dehydrogenase activity
GO:0033721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-acetaldehyde dehydrogenase activity
GO:0033721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde dehydrogenase (NADP+) activity
GO:0033721	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde:NADP+ oxidoreductase activity
REACT:R-DRE-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Danio rerio)
REACT:R-HSA-9609746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2B (GRIN2B) (Homo sapiens)
REACT:R-CFA-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Canis familiaris)
REACT:R-HSA-9006431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of IFNG gene (Homo sapiens)
RHEA:58738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-UMP + diphosphate + H(+) => H2O + TTP
EC:2.3.1.111	skos:prefLabel	"mycocerosate synthase"
EC:2.3.1.111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycocerosate synthase"
RHEA:29546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
REACT:R-SCE-9668419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Saccharomyces cerevisiae)
RHEA:17565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol 1-methyltransferase"
RHEA:17565	skos:altLabel	"myo-inositol 3-O-methyltransferase"
RHEA:17565	skos:altLabel	"S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase"
RHEA:17565	skos:altLabel	"inositol D-1-methyltransferase"
RHEA:17565	skos:prefLabel	"inositol 1-methyltransferase"
RHEA:17565	skos:altLabel	"S-adenosylmethionine:myo-inositol 3-methyltransferase"
RHEA:17565	skos:altLabel	"inositol 3-O-methyltransferase"
RHEA:17565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + S-adenosyl-L-methionine = 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Homo sapiens)
RHEA:25779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inosose <=> scyllo-inosine
RHEA:61153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
RHEA:36796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + 2 H2O => a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate
REACT:R-HSA-2129362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin microfibril assembly (Homo sapiens)
REACT:R-DRE-192178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP39A1 7-hydroxylates 24OH-CHOL (Danio rerio)
REACT:R-HSA-5662618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1G binds zinc (Homo sapiens)
REACT:R-HSA-5659781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 forms a heterodimer with BARD1 (Homo sapiens)
REACT:R-HSA-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Homo sapiens)
RHEA:24455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-[protein] + S-adenosyl-L-methionine <=> [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine
RHEA:16452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + kanamycin B <=> CoA + H(+) + N(6')-acetylkanamycin B
REACT:R-HSA-168166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
GO:0106431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-methyl-(d)ATP hydrolase activity
RHEA:15027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylxanthosine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthosine
REACT:R-MMU-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Mus musculus)
REACT:R-GGA-2685505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPCN1/2 transport lysosomal Ca2+ to cytosol  (Gallus gallus)
REACT:R-XTR-416985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to synapse (Xenopus tropicalis)
RHEA:66925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA => [(R)-3-hydroxyalkanoate](n+1) + CoA
RHEA:30338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + H2O <=> NH4(+) + UTP
REACT:R-GGA-4085347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SAFB with SUMO1 (Gallus gallus)
RHEA:35087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N'-monoacetylchitobiose-6'-phosphate = D-glucosamine + N-acetyl-D-glucosamine 6-phosphate
REACT:R-XTR-2022368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-42) (Xenopus tropicalis)
RHEA:58884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 = A + chloramphenicol + 2 H2O
RHEA:58884	skos:prefLabel	"alpha-N-dichloroacetyl-p-aminophenylserinol N-oxygenase"
RHEA:58884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-N-dichloroacetyl-p-aminophenylserinol N-oxygenase"
REACT:R-BTA-5625870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Bos taurus)
REACT:R-CFA-4754176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR3-histone H3 (Canis familiaris)
RHEA:38798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
GO:0034871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity
REACT:R-HSA-420980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Homo sapiens)
REACT:R-SSC-2046180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSPG is secreted from the cell (Sus scrofa)
REACT:R-BTA-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Bos taurus)
REACT:R-SSC-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Sus scrofa)
RHEA:35297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O + W-molybdopterin cofactor => adenylyl-molybdopterin + H(+) + tungstate
RHEA:46441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 => A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O
RHEA:69730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + ATP + H(+) <=> diphosphate + phenylacetyl-AMP
REACT:R-HSA-71825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (Homo sapiens)
REACT:R-BTA-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Bos taurus)
REACT:R-DME-538832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP1 dephosphorylates phosphorylated TIM in the complex with PER and DCO (Drosophila melanogaster)
RHEA:64546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine
REACT:R-MMU-3769394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CBY1 (Mus musculus)
GO:0001671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase activator activity
GO:0001671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase stimulator activity
RHEA:47860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b (d18:1(4E)) + H2O = ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate
REACT:R-SCE-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Saccharomyces cerevisiae)
RHEA:71078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-cystine(out) <=> L-arginine(out) + L-cystine(in)
REACT:R-DRE-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Danio rerio)
REACT:R-MMU-3134800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING dimerization (Mus musculus)
REACT:R-RNO-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Rattus norvegicus)
RHEA:49496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) = 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane
REACT:R-DRE-8939203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Danio rerio)
RHEA:53151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Caenorhabditis elegans)
RHEA:55575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine <=> 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine
RHEA:69810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-AMP + CoA <=> AMP + benzoyl-CoA + H(+)
REACT:R-HSA-8936058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-675 binds RUNX1 mRNA (Homo sapiens)
RHEA:20456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scopoletin + UDP-alpha-D-glucose <=> H(+) + scopolin + UDP
GO:0018780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dichloroacetate halidohydrolase activity
REACT:R-BTA-5676597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Bos taurus)
REACT:R-BTA-5638006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3 hydrolyzes GTP (Bos taurus)
REACT:R-MMU-1793207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses C4S/C6S chains (Mus musculus)
RHEA:43634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe) => an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe)
REACT:R-HSA-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
RHEA:47804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Mus musculus)
REACT:R-SCE-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Saccharomyces cerevisiae)
REACT:R-SPO-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Schizosaccharomyces pombe)
RHEA:59402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-2-aminohexanoate => L-2-aminohexanoate
REACT:R-MMU-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Mus musculus)
RHEA:66635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP
REACT:R-XTR-9749590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates ALB (Xenopus tropicalis)
REACT:R-SSC-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)
REACT:R-MMU-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Mus musculus)
RHEA:14612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + NADP(+) <=> H(+) + keto-L-sorbose + NADPH
REACT:R-CEL-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Caenorhabditis elegans)
REACT:R-DRE-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)
RHEA:24734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde
RHEA:31416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => (+)-2-epi-prezizaene + diphosphate
GO:0004319	skos:altLabel	"acyl-ACP dehydrogenase"
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl acyl-carrier-protein reductase activity
GO:0004319	skos:altLabel	"enoyl acyl-carrier-protein reductase"
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)"
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl-acyl-carrier-protein reductase (NADPH, B-specific)
GO:0004319	skos:altLabel	"enoyl-ACP reductase"
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
GO:0004319	skos:prefLabel	"enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)"
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enoyl-ACP reductase (NADPH, B-specific) activity
GO:0004319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH 2-enoyl Co A reductase activity
GO:0004319	skos:altLabel	"NADPH 2-enoyl Co A reductase"
REACT:R-GGA-9707977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)
REACT:R-CFA-9749471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
REACT:R-SSC-983218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B:RAD51C binds single-stranded DNA (Sus scrofa)
REACT:R-BTA-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Bos taurus)
REACT:R-BTA-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Bos taurus)
REACT:R-CEL-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)
RHEA:62458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-glutamyl-5'-AMP => ATP + H(+) + L-glutamate
REACT:R-BTA-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Bos taurus)
REACT:R-HSA-9668415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
RHEA:38927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-RNO-4332358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CaM and CAMK2 autophosphorylation (Rattus norvegicus)
RHEA:35583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate = D-glyceraldehyde + pyruvate
RHEA:35583	skos:altLabel	"KDG-specific aldolase"
RHEA:35583	skos:prefLabel	"2-dehydro-3-deoxy-D-gluconate aldolase"
RHEA:35583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-D-gluconate aldolase"
REACT:R-CFA-9693478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A agonists (Canis familiaris)
GO:0016727	skos:prefLabel	"With oxygen as acceptor"
GO:0016727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor
GO:0016727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
REACT:R-DRE-1606839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Steryl sulfatase hydrolyses sulfate from steroid sulfates (Danio rerio)
RHEA:22170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose => UDP-alpha-D-glucose
REACT:R-MMU-9638064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Mus musculus)
REACT:R-MMU-9013471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from 3MPYR to HCN to form HSCN (Mus musculus)
REACT:R-DME-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Drosophila melanogaster)
RHEA:42702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-[ACP] + H(+) + methanol => 6-carboxyhexanoyl-[ACP] methyl ester + H2O
RHEA:21044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylidenelophenol + S-adenosyl-L-methionine = (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine
RHEA:21044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"24-methylenesterol C-methyltransferase"
RHEA:21044	skos:altLabel	"24-methylenelophenol C-24(1)-methyltransferase"
RHEA:21044	skos:altLabel	"SMT2"
RHEA:21044	skos:prefLabel	"24-methylenesterol C-methyltransferase"
GO:0047429	skos:altLabel	"nucleoside-triphosphate diphosphatase"
GO:0047429	skos:altLabel	"dinucleotide nucleotidohydrolase"
GO:0047429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside triphosphate diphosphatase activity
GO:0047429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-triphosphate pyrophosphatase activity
GO:0047429	skos:prefLabel	"nucleotide diphosphatase"
GO:0047429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-triphosphate diphosphatase activity
GO:0047429	skos:altLabel	"nucleotide pyrophosphatase"
GO:0047429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside-triphosphate diphosphohydrolase activity
GO:0047429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleotide diphosphatase"
RHEA:30736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 4-phosphate + H2O => myo-inositol + phosphate
REACT:R-HSA-9626928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP binds FOXO1 (Homo sapiens)
REACT:R-RNO-8853801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPN binds RET:GFRA4 (Rattus norvegicus)
REACT:R-XTR-8948222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)
RHEA:12042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(imidazol-5-yl)pyruvate + H(+) + NADPH => (S)-3-(imidazol-5-yl)lactate + NADP(+)
REACT:R-RNO-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Rattus norvegicus)
REACT:R-DME-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Drosophila melanogaster)
REACT:R-BTA-1475017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Bos taurus)
RHEA:33866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-7 + succinate <=> fumarate + menaquinol-7
REACT:R-XTR-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Xenopus tropicalis)
REACT:R-HSA-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Homo sapiens)
RHEA:10813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + N-succinyl-L-glutamate + NADH
REACT:R-MMU-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)
RHEA:71456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	goralatide + H2O => L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate
REACT:R-BTA-381262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PPARG:RXRA heterodimer (ARF6 complex) (Bos taurus)
GO:0033922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidoglycan beta-N-acetylmuramidase activity
GO:0033922	skos:prefLabel	"peptidoglycan beta-N-acetylmuramidase"
GO:0033922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-acetylmuramidase activity
GO:0033922	skos:altLabel	"exo-beta-N-acetylmuramidase"
GO:0033922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity
GO:0033922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-N-acetylmuramidase activity
GO:0033922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidoglycan beta-N-acetylmuramoylexohydrolase activity
GO:0033922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidoglycan beta-N-acetylmuramidase"
REACT:R-DDI-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Dictyostelium discoideum)
REACT:R-SSC-749446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Sus scrofa)
RHEA:58996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + indole-3-carbaldehyde + O2 = H(+) + H2O2 + indole-3-carboxylate
REACT:R-MMU-5692764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 binds CCND3 (Mus musculus)
REACT:R-HSA-420592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectin-like (Necl) proteins (Homo sapiens)
REACT:R-SPO-2730868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK7 by MEKK1 (Schizosaccharomyces pombe)
REACT:R-GGA-419490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATP to P2X receptors (Gallus gallus)
REACT:R-MMU-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)
RHEA:69568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate + NH4(+)
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein serine-threonine kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein kinase (phosphorylating) activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serine protein kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serine kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein serine kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein-serine kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	threonine-specific protein kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine/threonine protein kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine(threonine) protein kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein threonine kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein serine/threonine kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serine-specific protein kinase activity
GO:0004674	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protein phosphokinase activity
RHEA:18400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)
REACT:R-SSC-5223317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB9 transports peptides from cytosol to lysosomal lumen (Sus scrofa)
REACT:R-CEL-1592398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP8 (Caenorhabditis elegans)
REACT:R-DRE-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Danio rerio)
RHEA:29436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin(in) + H(+)(out) => enterobactin(out) + H(+)(in)
REACT:R-BTA-8982163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)
RHEA:11233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + sulfate
RHEA:30544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine + ATP + CoA => (S)-carnitinyl-CoA + ADP + phosphate
REACT:R-HSA-159050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)
RHEA:17605	skos:altLabel	"TTL"
RHEA:17605	skos:prefLabel	"tubulin--tyrosine ligase"
RHEA:17605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tubulin--tyrosine ligase"
RHEA:17605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine = ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate
RHEA:17162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dioxo-6-phenylhexa-3-enoate + H2O => 2-oxopent-4-enoate + benzoate + H(+)
REACT:R-HSA-9656781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deltarasin binds PDE6D (Homo sapiens)
REACT:R-RNO-5682863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF168 binds DNA DSBs (Rattus norvegicus)
REACT:R-SSC-6784676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Sus scrofa)
REACT:R-MMU-210974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS-1 to Tie2 bound  Grb2 (Mus musculus)
REACT:R-HSA-9020255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Homo sapiens)
REACT:R-RNO-3134883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin enhances association of IRF3 with CBP/p300  (Rattus norvegicus)
RHEA:51947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine <=> 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine
RHEA:18973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deacetoxyvindoline 4-hydroxylase"
RHEA:18973	skos:altLabel	"desacetyoxyvindoline-17-hydroxylase"
RHEA:18973	skos:altLabel	"desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)"
RHEA:18973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 = 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate
RHEA:18973	skos:altLabel	"D17H"
RHEA:18973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + deacetoxyvindoline + O2 = 4-O-deacetylvindoline + CO2 + succinate
RHEA:18973	skos:prefLabel	"deacetoxyvindoline 4-hydroxylase"
RHEA:18973	skos:altLabel	"desacetoxyvindoline-4-hydroxylase"
REACT:R-XTR-5634802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Xenopus tropicalis)
REACT:R-RNO-9708533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)
REACT:R-MMU-5615637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Mus musculus)
RHEA:37471	skos:prefLabel	"isovaleryl-homoserine lactone synthase"
RHEA:37471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isovaleryl-homoserine lactone synthase"
RHEA:37471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine
RHEA:37471	skos:altLabel	"IV-HSL synthase"
REACT:R-MMU-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Mus musculus)
RHEA:44276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:30659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(phosphooxy)-L-threonine + H2O = 4-hydroxy-L-threonine + phosphate
REACT:R-MMU-1592297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full activation of MMP1 (Mus musculus)
GO:0047309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylalanine-DOPP transaminase (PDT)
GO:0047309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity
GO:0047309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-dopa transaminase activity
GO:0047309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate-DOPP transaminase (GDT)
GO:0047309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DOPA aminotransferase activity
GO:0047309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate-DOPP transaminase (ADT)
GO:0047309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyphenylalanine transaminase activity
GO:0047309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyphenylalanine aminotransferase activity
GO:0047309	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dopa transaminase activity
RHEA:23588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate + succinyl-CoA = oxalyl-CoA + succinate
RHEA:23588	skos:altLabel	"succinyl--beta-ketoacyl-CoA transferase"
RHEA:23588	skos:prefLabel	"oxalate CoA-transferase"
RHEA:23588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxalate CoA-transferase"
REACT:R-XTR-9645394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Xenopus tropicalis)
GO:0051477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosylglycerate transmembrane transporter activity
REACT:R-DRE-170844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 is cleaved by FURIN (Danio rerio)
REACT:R-DME-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Drosophila melanogaster)
REACT:R-XTR-5690080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP3,SAGA deubiquitinate Histone H2A,H2B (Xenopus tropicalis)
RHEA:45999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + a quinone + H2O <=> a 2-oxocarboxylate + a quinol + NH4(+)
RHEA:64794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+) => L-lysine + NADP(+)
REACT:R-DME-5654603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS3 (Drosophila melanogaster)
RHEA:45776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetonitrile + 2 H2O = (indol-3-yl)acetate + NH4(+)
REACT:R-BTA-5688276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT4 transfers ADPRib to GLUD (Bos taurus)
REACT:R-CFA-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Canis familiaris)
RHEA:67098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + fumigatonoid A + succinate => 2-oxoglutarate + asnovolin A + 2 O2
REACT:R-CFA-913360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF receptor alpha subunit binds GM-CSF (Canis familiaris)
RHEA:60644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + androsterone = adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)
REACT:R-CFA-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Canis familiaris)
RHEA:40011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O = diphosphate + manool
REACT:R-GGA-2187401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 dephosphorylates SMAD2/3 (Gallus gallus)
REACT:R-DDI-1482543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Dictyostelium discoideum)
RHEA:21151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose <=> 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP
REACT:R-MMU-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Mus musculus)
RHEA:39020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
RHEA:59042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2
RHEA:18558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA
RHEA:37135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-CFA-5674019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds KSR1:MARK3 (Canis familiaris)
GO:0032052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bile acid binding
RHEA:64722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + pyruvate(in) => H(+)(out) + pyruvate(out)
RHEA:41194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate
REACT:R-HSA-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Homo sapiens)
REACT:R-DME-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Drosophila melanogaster)
RHEA:22388	skos:altLabel	"N(6)-hydroxylysine acetylase"
RHEA:22388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N(6)-hydroxy-L-lysine = CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine
RHEA:22388	skos:prefLabel	"N(6)-hydroxylysine O-acetyltransferase"
RHEA:22388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(6)-hydroxylysine O-acetyltransferase"
REACT:R-BTA-9748979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Bos taurus)
RHEA:40295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexadecanedioate = AMP + diphosphate + hexadecanedioyl-CoA
RHEA:30240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n a quinone + n H(+) + n hydrogen sulfide => n a quinol + n sulfur
REACT:R-RNO-983422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of COPII coated vesicle (Rattus norvegicus)
RHEA:39009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cholesterol ester(out) => a cholesterol ester(in)
REACT:R-BTA-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Bos taurus)
REACT:R-GGA-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Gallus gallus)
REACT:R-SCE-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Saccharomyces cerevisiae)
RHEA:46595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]
RHEA:17249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(2+) + 2 H2O + H2O2 = 6 H(+) + 2 iron(III) oxide-hydroxide
RHEA:44057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA
REACT:R-DRE-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
GO:0043825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO:0043825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinylornithine transaminase activity
GO:0043825	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succinylornithine aminotransferase activity
GO:0043825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2-succinylornithine 5-aminotransferase activity
GO:0043825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl ornithine transaminase activity
GO:0043825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(2)-succinylornithine 5-aminotransferase activity
GO:0043825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-ornithine transaminase activity
GO:0043825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SOAT
GO:0043825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO:0043825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AstC
GO:0036383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity
REACT:R-GGA-873919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Gallus gallus)
RHEA:39699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-(13Z)-eicosenoyl-CoA = (2E,13Z)-eicosadienoyl-CoA + H2O
GO:0047777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-CMA-CoA lyase activity
GO:0047777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-citramalyl-CoA lyase activity
GO:0047777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
GO:0047777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citramalyl coenzyme A lyase activity
GO:0047777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-citramalyl-CoA pyruvate-lyase activity
GO:0047777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	citramalyl-CoA lyase activity
GO:0047777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-citramalyl-CoA lyase activity
REACT:R-HSA-5637796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)
REACT:R-DRE-1566981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Danio rerio)
REACT:R-DRE-202459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Bcl10 (Danio rerio)
REACT:R-SSC-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Sus scrofa)
RHEA:50527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]
REACT:R-HSA-70830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA (Homo sapiens)
REACT:R-DME-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Drosophila melanogaster)
RHEA:36489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine => agmatine + S-adenosyl 3-(methylsulfanyl)propylamine
REACT:R-MMU-2396599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-5Y-LAT (Mus musculus)
REACT:R-CFA-74885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCYs converts GTP to cGMP (Canis familiaris)
RHEA:20472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP <=> D-ribose 5-phosphate + hypoxanthine
REACT:R-DRE-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Danio rerio)
RHEA:72148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + S-adenosyl-L-methionine + UTP => 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine
REACT:R-SSC-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Sus scrofa)
REACT:R-DDI-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Dictyostelium discoideum)
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP diglyceride pyrophosphorylase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP-diacylglycerol synthetase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diacylglyceride synthetase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:phosphatidate cytidylyltransferase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidic acid cytidylyltransferase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-DG
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:1,2-diacylglycerophosphate-cytidyl transferase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-diglyceride synthase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-diacylglycerol synthase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-diglyceride diphosphorylase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoglyceride pyrophosphorylase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DAG synthetase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidate cytidylyltransferase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-diglyceride pyrophosphorylase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diglyceride synthetase activity
GO:0004605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidate cytidyltransferase activity
REACT:R-HSA-6810643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPPIN protein complex binds bacteria (Homo sapiens)
REACT:R-RNO-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Rattus norvegicus)
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose phosphate diphosphokinase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose-phosphate pyrophosphokinase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphoribose pyrophosphorylase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPRibP synthetase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl-diphosphate synthetase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl pyrophosphate synthetase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribophosphate pyrophosphokinase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylpyrophosphate synthetase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-ribose-5-phosphate diphosphotransferase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribose-phosphate diphosphokinase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-phosphoribosyl-1-pyrophosphate synthetase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrophosphoribosylphosphate synthetase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PRPP synthetase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribose-5-phosphate pyrophosphokinase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl diphosphate synthetase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Homo sapiens)
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PP-ribose P synthetase activity
GO:0004749	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylpyrophosphate synthase activity
RHEA:66529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]
RHEA:10502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ethylmalate + CoA + H(+) => butanoyl-CoA + glyoxylate + H2O
REACT:R-MMU-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Mus musculus)
RHEA:17774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-cysteine + tRNA(Cys) => AMP + diphosphate + L-cysteinyl-tRNA(Cys)
RHEA:63961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisate(out) + ATP + H2O => abscisate(in) + ADP + H(+) + phosphate
REACT:R-DRE-8955241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)
RHEA:58324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine
REACT:R-GGA-6810843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Envoplakin binds periplakin (Gallus gallus)
RHEA:64729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate
REACT:R-BTA-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Bos taurus)
REACT:R-MMU-9708536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 translocates from the cytosol to the nucleoplasm (Mus musculus)
REACT:R-CEL-9604328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates NOTCH4 (Caenorhabditis elegans)
REACT:R-XTR-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Xenopus tropicalis)
REACT:R-DRE-5687675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates remaining SSBs in MMEJ (Danio rerio)
RHEA:51312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine
REACT:R-HSA-204600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Basigin homodimerises (Homo sapiens)
REACT:R-HSA-5621573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD209 activate GTPase RAS (Homo sapiens)
RHEA:36054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O <=> 2 beta-L-arabinofuranose
REACT:R-SSC-380942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LKB1 forms a trimeric complex with STRAD and MO25 (Sus scrofa)
RHEA:39583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)
REACT:R-BTA-3229089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Bos taurus)
RHEA:59839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate
RHEA:72975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 indole-3-pyruvate = 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)
RHEA:10858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose
RHEA:70285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanal + H2O2 + NH4(+) => H2O + N-acetylputrescine + O2
REACT:R-GGA-9010815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLITs bind keratan sulfate (Gallus gallus)
GO:0004999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vasoactive intestinal polypeptide receptor activity
RHEA:54690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + allylsulfenate => alliin
REACT:R-XTR-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Xenopus tropicalis)
RHEA:64725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate
RHEA:44587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-CFA-5691507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPA deacetylates NAA to acetate and L-aspartate (Canis familiaris)
RHEA:32147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sepiapterin = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)
RHEA:51630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dUTP + H2O => formate + H(+) + UTP
RHEA:19257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH
REACT:R-DRE-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Danio rerio)
REACT:R-CEL-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Caenorhabditis elegans)
EC:1.10.3.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"photosystem II"
EC:1.10.3.9	skos:prefLabel	"photosystem II"
RHEA:43254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O
GO:0102997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	progesterone 5beta- reductase activity
REACT:R-DME-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Drosophila melanogaster)
GO:0071906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	context dependent regulatory domain binding
GO:0071906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRD domain binding
REACT:R-MMU-5690046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT2 hydrolyses PALMCoA to PALM (Mus musculus)
RHEA:30437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly)
RHEA:25296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + 2 H(+) + NADH => acetaldehyde + H2O + NAD(+)
RHEA:55991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
REACT:R-SSC-8851827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Sus scrofa)
GO:0034602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxoglutarate dehydrogenase (NAD+) activity
RHEA:69958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + 3 Na(+)(out) <=> Ca(2+)(out) + 3 Na(+)(in)
GO:0052766	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-1,4-mannosidase activity
GO:0052766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannoside alpha-1,4-exomannosidase activity
GO:0052766	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-1,4-exomannosidase activity
GO:0052766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannoside exo-alpha-1,4-mannosidase activity
GO:0052766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannoside alpha-1,4-mannosidase activity
GO:0043912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine oxidase activity
REACT:R-MMU-9690493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors on endosomes (Mus musculus)
REACT:R-SSC-1482907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Sus scrofa)
GO:2001078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-(1->6)-D-glucan binding
GO:2001078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-beta-D-glucan binding
GO:2001078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1->6-beta-D-glucan binding
GO:2001078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-(1,6)-D-glucan binding
GO:2001078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1->6)-beta-D-glucan binding
GO:2001078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,6-D-glucan binding
GO:2001078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1->6-D-glucan binding
GO:2001078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1,6)-beta-D-glucan binding
GO:0050101	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mimosine amidohydrolase activity
GO:0050101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mimosinase activity
RHEA:27591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + ADP + H(+) + phosphate
REACT:R-XTR-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Xenopus tropicalis)
RHEA:37396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:48168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate
RHEA:48835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
REACT:R-HSA-901097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2] (Homo sapiens)
GO:0050423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine dehydrogenase activity
GO:0050423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine oxidase activity
GO:0050423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine:oxygen 5-oxidoreductase activity
GO:0050423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin:oxygen 5-oxidoreductase activity
GO:0050423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin oxidase activity
GO:0050423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamin dehydrogenase activity
RHEA:51726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-tetraphosphate + ADP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate
REACT:R-MMU-8848414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds CDKN1B (Mus musculus)
REACT:R-HSA-391158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP alpha binds CD47 (Homo sapiens)
REACT:R-DRE-5693807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUCA1 hydrolyses NGP:1,6-GlcNAc (Danio rerio)
RHEA:59868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine = 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)
RHEA:69215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate
REACT:R-SPO-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Schizosaccharomyces pombe)
REACT:R-SSC-6805638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A acetylates TP53 (Sus scrofa)
REACT:R-SSC-72647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cap-bound mRNA is activated by helicases  (Sus scrofa)
REACT:R-BTA-4551721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VHL with SUMO1 (Bos taurus)
REACT:R-BTA-212713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLC-gamma1 dissociates from EGFR (Bos taurus)
RHEA:55050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-dodecadienoate + CoA + H(+) => (3E,5Z)-dodecadienoyl-CoA + H2O
REACT:R-CEL-9661799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)
GO:0015225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin(in) = biotin(out)
GO:0015225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin B7 transporter activity
GO:0015225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin H transporter activity
GO:0015225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin transporter activity
GO:0015225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin transmembrane transporter activity
REACT:R-MMU-71588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Mus musculus)
REACT:R-DME-4615987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO2,3 (Drosophila melanogaster)
REACT:R-CFA-1676005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)
RHEA:10593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Caenorhabditis elegans)
REACT:R-BTA-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Bos taurus)
REACT:R-XTR-1237059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ dehydrates HCO3- to CO2 (Xenopus tropicalis)
GO:0047272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:phosphopolyprenol D-glucosyltransferase activity
GO:0047272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:polyprenol monophosphate glucosyltransferase activity
GO:0047272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:phosphopolyprenol D-glucosyltransferase activity
GO:0047272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopolyprenol glucosyltransferase activity
GO:0047272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity
REACT:R-CEL-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Caenorhabditis elegans)
RHEA:48848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-SPO-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Schizosaccharomyces pombe)
REACT:R-CEL-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Caenorhabditis elegans)
REACT:R-CFA-2046239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular KSPG translocates to the lysosome for degradation (Canis familiaris)
RHEA:29854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N-acetyl-alpha-D-galactosamine <=> 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP
REACT:R-BTA-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Bos taurus)
REACT:R-HSA-9018859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Homo sapiens)
GO:0097600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exoxylanase activity
REACT:R-CFA-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Canis familiaris)
RHEA:13068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O <=> ADP + H(+) + phosphate
REACT:R-DME-200410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Drosophila melanogaster)
RHEA:41226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:14474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) => a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH
GO:0036430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP kinase activity
RHEA:48805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
REACT:R-RNO-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Rattus norvegicus)
REACT:R-SSC-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Sus scrofa)
REACT:R-CFA-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)
REACT:R-MMU-4088130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds FOXM1 (Mus musculus)
REACT:R-RNO-77615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR2) (Rattus norvegicus)
REACT:R-HSA-5603067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown nuclease cleaves pre-piRNA in ASZ1:DDX4:MOV10L1:6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12 (Homo sapiens)
REACT:R-DRE-189398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
REACT:R-SCE-163664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binds to gamma subunit of AMP kinase heterotrimer (Saccharomyces cerevisiae)
REACT:R-SSC-1170539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor is internalized (Sus scrofa)
RHEA:55020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate
REACT:R-HSA-6797913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARDH:FAD oxidatively demethylates SARC to Gly (Homo sapiens)
REACT:R-DRE-450690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Danio rerio)
REACT:R-SSC-113429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongating transcript encounters a lesion in the template (Sus scrofa)
RHEA:47618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethionamide S-oxide + H2O + NADP(+) => ethionamide + H(+) + NADPH + O2
REACT:R-RNO-8956026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL9:RBX1 ubiquitinates BIRC5 (Rattus norvegicus)
RHEA:31153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-selenocysteine + NH4(+) => H2O + L-selenocystathionine
RHEA:49848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid ketone + a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)
RHEA:51337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate
EC:2.1.1.349	skos:prefLabel	"toxoflavin synthase"
EC:2.1.1.349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"toxoflavin synthase"
RHEA:23230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-hydroxy-L-lysine + NADP(+) => L-lysine + NADPH + O2
GO:0018736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity
RHEA:70942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) <=> L-methionine(out)
REACT:R-BTA-1297338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of ADAM and B4GALT1 With ZP3 (Bos taurus)
REACT:R-HSA-174741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Homo sapiens)
RHEA:72490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + phosphoenolpyruvate(in) <=> citrate(in) + phosphoenolpyruvate(out)
REACT:R-GGA-913424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)
RHEA:32312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
GO:0004608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity
GO:0004608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylethanolamine N-methyltransferase activity
GO:0004608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylethanolamine-N-methylase activity
GO:0004608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylethanolamine methyltransferase activity
GO:0004608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LMTase activity
GO:0004608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity
GO:0004608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEMT
GO:0004608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipid methyl transferase activity
REACT:R-BTA-449058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family are secreted (Bos taurus)
REACT:R-DME-5687673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN recruits LIG3:XRCC1 to MMEJ sites (Drosophila melanogaster)
RHEA:48130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl phosphate + H(+) + phosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-XTR-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Xenopus tropicalis)
REACT:R-MMU-4420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 disassociates from VEGFR2 and translocate to PM (Mus musculus)
REACT:R-BTA-6809808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Bos taurus)
REACT:R-HSA-445797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLK (MLCK) Active Calmodulin Binding (Homo sapiens)
REACT:R-XTR-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Xenopus tropicalis)
REACT:R-DME-975040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAB-ZNF / KAP Interaction (Drosophila melanogaster)
EC:1.1.99.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyranose dehydrogenase (acceptor)"
EC:1.1.99.29	skos:altLabel	"PDH"
EC:1.1.99.29	skos:altLabel	"pyranose dehydrogenase"
EC:1.1.99.29	skos:altLabel	"pyranose-quinone oxidoreductase"
EC:1.1.99.29	skos:prefLabel	"pyranose dehydrogenase (acceptor)"
EC:1.1.99.29	skos:altLabel	"quinone-dependent pyranose dehydrogenase"
REACT:R-CFA-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)
RHEA:31138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate <=> 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate
REACT:R-HSA-5621371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4C binds HIV and HCV glycoproteins (Homo sapiens)
RHEA:41551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Canis familiaris)
REACT:R-DRE-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Danio rerio)
RHEA:47966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + phosphate => H2O + N(pros)-phospho-L-histidyl-[protein]
REACT:R-DRE-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Danio rerio)
REACT:R-MMU-8848316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36 binds IL1RL2 (Mus musculus)
REACT:R-RNO-1028817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Rattus norvegicus)
REACT:R-HSA-180885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rev multimer-bound HIV mRNA associates with Crm1 (Homo sapiens)
RHEA:64712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + NADP(+) = H(+) + NADPH + propanal
REACT:R-GGA-4332235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds TGFBR2 (Gallus gallus)
REACT:R-BTA-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Bos taurus)
RHEA:47174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+)
REACT:R-MMU-8937631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Mus musculus)
REACT:R-CEL-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Caenorhabditis elegans)
REACT:R-HSA-168929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral dsRNA:TLR3 recruits TRIF (TICAM1) (Homo sapiens)
REACT:R-DRE-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Danio rerio)
RHEA:29904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose(out) + H2O => ADP + D-ribose(in) + H(+) + phosphate
REACT:R-XTR-8986985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Xenopus tropicalis)
REACT:R-CFA-3782655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC10 deacetylates histone (Canis familiaris)
REACT:R-SSC-201677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Sus scrofa)
RHEA:44574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-heptaprenylphenol + CO2 => 4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+)
REACT:R-RNO-3343700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
RHEA:31517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + neurosporaxanthin => 4'-apo-beta-carotenal + H2O + NAD(+)
REACT:R-SSC-8948222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)
RHEA:52370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholesterol
REACT:R-XTR-8867370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Xenopus tropicalis)
REACT:R-CFA-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Canis familiaris)
RHEA:64929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dADP + H2O => dAMP + H(+) + phosphate
REACT:R-BTA-1855200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Bos taurus)
REACT:R-CEL-9734535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Caenorhabditis elegans)
REACT:R-SSC-1678944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Sus scrofa)
RHEA:46295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate
RHEA:22373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + propionate 3-nitronate => 3-oxopropanoate + H(+) + H2O2 + nitrite
RHEA:31497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose
RHEA:16518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-ol + NAD(+) => aminoacetone + H(+) + NADH
REACT:R-CFA-9758090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)
REACT:R-MMU-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Mus musculus)
GO:0036199	skos:altLabel	"cholest-4-en-3-one 26-monooxygenase"
GO:0036199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
GO:0036199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one 26-monooxygenase activity
GO:0036199	skos:altLabel	"CYP125"
GO:0036199	skos:altLabel	"cholest-4-en-3-one 27-monooxygenase"
GO:0036199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]"
GO:0036199	skos:altLabel	"CYP125A1"
GO:0036199	skos:prefLabel	"cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]"
REACT:R-DME-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Drosophila melanogaster)
RHEA:62587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-tyrosine(out) <=> ADP + H(+) + L-tyrosine(in) + phosphate
RHEA:31418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphate
REACT:R-BTA-9693324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disulfiram covalently modifies Cys191 in GSDMD (Bos taurus)
RHEA:70781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-dehydro-D-glucose + H(+) + NADPH => D-glucose + NADP(+)
EC:3.4.24.57	skos:prefLabel	"O-sialoglycoprotein endopeptidase"
EC:3.4.24.57	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-sialoglycoprotein endopeptidase"
EC:3.4.24.57	skos:altLabel	"glycoprotease"
RHEA:11521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol + UDP-alpha-D-glucose => (-)-menthyl beta-D-glucoside + H(+) + UDP
REACT:R-CFA-2537665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin-1 and -2 bind fibronectin (Canis familiaris)
REACT:R-HSA-9725338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM-ALK-dependent BCL2A1 gene expression (Homo sapiens)
REACT:R-SSC-389381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gads binds CD28 (Sus scrofa)
RHEA:53750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose
RHEA:57582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-1-thiol-D-ribulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate
REACT:R-HSA-2213210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen IX is cross-linked to the surface of collagen type II fibrils (Homo sapiens)
REACT:R-RNO-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Rattus norvegicus)
GO:0002046	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	metarhodopsin binding
GO:0002046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	opsin binding
GO:0001972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinoic acid binding
RHEA:64059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-ephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
REACT:R-DDI-264458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of COP1 (Dictyostelium discoideum)
RHEA:69076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)
REACT:R-BTA-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Bos taurus)
REACT:R-SSC-202718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Sus scrofa)
RHEA:38226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + decan-1-ol <=> 1-O-decyl-(9Z)-octadecenoate + CoA
RHEA:10333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
REACT:R-SCE-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Saccharomyces cerevisiae)
REACT:R-CFA-3858495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits GTP-bound RHOA (Canis familiaris)
REACT:R-HSA-5423664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)
RHEA:44702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-CoA + FADH2 => a 2,3-saturated acyl-CoA + FAD + H(+)
RHEA:67036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 = (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate
REACT:R-CFA-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
REACT:R-DRE-927832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
REACT:R-DDI-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Dictyostelium discoideum)
REACT:R-MMU-5251955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Mus musculus)
REACT:R-MMU-5661240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCXR tetramer reduces L-xylulose to xylitol (Mus musculus)
REACT:R-RNO-166721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Rattus norvegicus)
RHEA:32272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate + NAD(+) => 4-methyl-2-oxopentanoate + CO2 + NADH
REACT:R-BTA-2028724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMOT proteins bind YAP1 (Bos taurus)
REACT:R-CFA-8983983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Canis familiaris)
REACT:R-CFA-2172678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF8 demethylates histone H4K20me1 (Canis familiaris)
REACT:R-SPO-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Schizosaccharomyces pombe)
RHEA:47306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:49246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-oxo-resolvin E1 + H(+) + NADH => NAD(+) + resolvin E1
RHEA:20825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + ATP => ADP + AMP + H(+)
RHEA:63298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine => an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine
REACT:R-XTR-201637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plectin-1 (Xenopus tropicalis)
REACT:R-GGA-75949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II Promoter Opening: First Transition (Gallus gallus)
REACT:R-BTA-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Bos taurus)
REACT:R-MMU-2022398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Mus musculus)
REACT:R-BTA-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Bos taurus)
REACT:R-MMU-8851954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)
REACT:R-CFA-5682794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM22 and ADAM23 (Canis familiaris)
RHEA:42865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermine + S-methyl-5'-thioadenosine
REACT:R-BTA-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Bos taurus)
RHEA:21547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + ATP <=> (2E,6E)-farnesyl triphosphate + ADP
RHEA:48804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
RHEA:48705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 12S-HpEPE
REACT:R-HSA-8857583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by PTK6 (Homo sapiens)
REACT:R-MMU-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Mus musculus)
REACT:R-CEL-1234159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)
REACT:R-SSC-70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Sus scrofa)
REACT:R-DME-8937989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PRC1 complexes (Drosophila melanogaster)
REACT:R-XTR-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)
RHEA:28955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucuronate(in) + H(+)(in) = aldehydo-D-glucuronate(out) + H(+)(out)
GO:0016646	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0016646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
GO:0016646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
RHEA:16922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-HSA-2730842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K associates with phosphorylated GAB2 (Homo sapiens)
GO:0018828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	halohydrin hydrogen-halide-lyase A activity
REACT:R-CEL-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
GO:0043740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP 8,9-dihydrolase (phosphate-forming)
GO:0043740	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GTP cyclohydrolase III activity
GO:0043740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP cyclohydrolase IIa activity
GO:0043740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP 8,9-hydrolase (phosphate-forming)
RHEA:24341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-butane-2,3-diol + NAD(+) => (R)-acetoin + H(+) + NADH
REACT:R-RNO-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Rattus norvegicus)
REACT:R-CFA-6799197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Canis familiaris)
REACT:R-DRE-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Danio rerio)
RHEA:51701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthogalenol => 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-4088130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds FOXM1 (Danio rerio)
REACT:R-HSA-83582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Homo sapiens)
RHEA:64689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP
REACT:R-BTA-8856157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAG3 (CD233) binds MHC II (Bos taurus)
RHEA:47343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-3134883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin enhances association of IRF3 with CBP/p300  (Homo sapiens)
REACT:R-XTR-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Xenopus tropicalis)
REACT:R-SPO-4086083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of ING2 with SUMO1 (Schizosaccharomyces pombe)
REACT:R-DRE-156723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF20A (MKL2) by phosphorylation (Danio rerio)
GO:0106254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid sensor activity
GO:0106254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid sensing activity
RHEA:44659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Rattus norvegicus)
EC:3.4.24.47	skos:prefLabel	"horrilysin"
EC:3.4.24.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"horrilysin"
EC:3.4.24.47	skos:altLabel	"Crotalus horridus metalloendopeptidase"
EC:3.4.24.47	skos:altLabel	"hemorrhagic proteinase IV"
REACT:R-CFA-5218854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y420-FYN is phosphorylated on S21 (Canis familiaris)
REACT:R-SPO-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Schizosaccharomyces pombe)
RHEA:50346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+) => 3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH
REACT:R-XTR-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Xenopus tropicalis)
RHEA:71759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + heptanedioate(in) = 2-oxoglutarate(in) + heptanedioate(out)
GO:0140571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ascorbate ferrireductase (transmembrane)"
GO:0140571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascorbate-cytochrome b5 reductase activity
GO:0140571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate-cytochrome-b5 reductase activity
GO:0140571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)
GO:0140571	skos:prefLabel	"ascorbate ferrireductase (transmembrane)"
GO:0140571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate:ferricytochrome-b5 oxidoreductase activity
GO:0140571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane ascorbate ferrireductase activity
GO:0140571	skos:altLabel	"cytochrome b561"
REACT:R-CEL-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Caenorhabditis elegans)
REACT:R-HSA-9674430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFR mutants bind type II TKIs (Homo sapiens)
REACT:R-DRE-8948063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Danio rerio)
RHEA:41357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacteriochlorophyll a + 3 NADP(+) => geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH
RHEA:34908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdate(in) => molybdate(out)
GO:0004961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXA(2) receptor activity
GO:0004961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXA2 receptor activity
GO:0004961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thromboxane A2 receptor activity
REACT:R-DDI-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Dictyostelium discoideum)
REACT:R-MMU-9667914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand midkine (MDK) (Mus musculus)
RHEA:22865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine => D-lysine
RHEA:57495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate + propanoyl-CoA <=> 2-methylcitrate + CoA + H(+)
RHEA:30064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + S-adenosyl-L-methionine => H(+) + menaquinol-8 + S-adenosyl-L-homocysteine
REACT:R-HSA-180591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vpu:CD4 associates with beta-TrCP (Homo sapiens)
GO:0004030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALD3A1 oxidises 4HPCP to CXPA (Homo sapiens)
GO:0004030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde:NAD(P)+ oxidoreductase activity
GO:0004030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde dehydrogenase [NAD(P)+] activity
GO:0004030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ALDH
RHEA:41087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-5359451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from SAM to NAM to form MNA (Xenopus tropicalis)
REACT:R-MMU-8951498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Mus musculus)
RHEA:14038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH
REACT:R-MMU-976810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to extracellular Factor H:C3b (Mus musculus)
RHEA:48756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythritol + NAD(+) = D-erythrulose + H(+) + NADH
REACT:R-RNO-352059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A15-mediated amino acid uptake (Rattus norvegicus)
RHEA:54746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:51595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene <=> benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Rattus norvegicus)
REACT:R-XTR-109480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Xenopus tropicalis)
RHEA:37567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-BTA-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Bos taurus)
REACT:R-RNO-917693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESCRT Disassembly (Rattus norvegicus)
REACT:R-SSC-8868230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)
REACT:R-XTR-9024993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Xenopus tropicalis)
GO:0051995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Se-methyltransferase activity
REACT:R-XTR-9650165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers bind H+ (Xenopus tropicalis)
RHEA:57567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0044585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellobiose binding
REACT:R-MMU-71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Mus musculus)
REACT:R-MMU-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Mus musculus)
REACT:R-DDI-381186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Dictyostelium discoideum)
RHEA:54909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (4E)-hexenoyl-CoA + NADP(+)
REACT:R-XTR-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Xenopus tropicalis)
RHEA:47972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O
RHEA:47972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase"
RHEA:47972	skos:prefLabel	"dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase"
REACT:R-MMU-5687112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 is degraded by the 26S proteasome (Mus musculus)
REACT:R-SSC-8878914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Sus scrofa)
REACT:R-SSC-2730870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)
RHEA:53251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Schizosaccharomyces pombe)
REACT:R-SCE-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
REACT:R-HSA-3238691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-linked glycosylation of WNTs (Homo sapiens)
RHEA:34780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3alpha-hydroxysteroid + NAD(+) => a 3-oxosteroid + H(+) + NADH
RHEA:40649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O
GO:0080122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine monophosphate transmembrane transporter activity
GO:0080122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP transmembrane transporter activity
REACT:R-DRE-9706390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds interacting proteins at trans-Golgi network (Danio rerio)
REACT:R-DME-380780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Src (Drosophila melanogaster)
RHEA:52153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-indolylmethyl desulfoglucosinolate + UDP
REACT:R-RNO-216069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaDbeta2 with fibrin (Rattus norvegicus)
REACT:R-RNO-6794355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 binds mGluR1a,5 (Rattus norvegicus)
REACT:R-DDI-2161899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)
REACT:R-DRE-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
REACT:R-SSC-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Sus scrofa)
REACT:R-DRE-5695957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Danio rerio)
REACT:R-CFA-9605609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Canis familiaris)
REACT:R-HSA-8944229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type IX (Homo sapiens)
REACT:R-RNO-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Rattus norvegicus)
REACT:R-HSA-6814675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Homo sapiens)
RHEA:72126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-butanoyl-(R)-carnitine(out) <=> Na(+)(in) + O-butanoyl-(R)-carnitine(in)
GO:0009009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	site-specific recombinase activity
GO:0009009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RecA-family recombinase activity
REACT:R-GGA-6785213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer binds heparin (Gallus gallus)
REACT:R-GGA-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Gallus gallus)
RHEA:51099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:65142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + berkeleyone A + H2O => AH2 + O2 + protoaustinoid A
REACT:R-SPO-350604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Agmatine + H2O <=> putrescine + urea (Schizosaccharomyces pombe)
REACT:R-BTA-1604690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MMP9 intermediate form by MMPs (Bos taurus)
REACT:R-XTR-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Xenopus tropicalis)
REACT:R-XTR-8937419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBR3 reduces DOX to DOXOL (Xenopus tropicalis)
RHEA:43782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:15723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H(+) + NADH + NH4(+) => glycine + H2O + NAD(+)
REACT:R-DRE-202960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of C-IAP1 (Danio rerio)
REACT:R-SCE-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Saccharomyces cerevisiae)
REACT:R-DME-450827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Drosophila melanogaster)
REACT:R-XTR-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Xenopus tropicalis)
RHEA:37623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-RNO-1638053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from keratan sulfate (Rattus norvegicus)
RHEA:34452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-beta-L-talose => dTDP-beta-L-rhamnose
REACT:R-CEL-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Caenorhabditis elegans)
REACT:R-CFA-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Canis familiaris)
RHEA:58746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+) + N(7)-methyl-GMP => H2O + N(7)-methyl-GTP
REACT:R-HSA-5683113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia (Homo sapiens)
REACT:R-CFA-209891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine is oxidised to noradrenaline (Canis familiaris)
RHEA:14346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-tyrosine => CO2 + tyramine
RHEA:15505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + H(+) + NADH
RHEA:15505	skos:prefLabel	"2-hydroxymethylglutarate dehydrogenase"
RHEA:15505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxymethylglutarate dehydrogenase"
EC:5.1.1.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyproline betaine 2-epimerase"
EC:5.1.1.22	skos:prefLabel	"4-hydroxyproline betaine 2-epimerase"
REACT:R-CFA-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)
REACT:R-DRE-508247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
REACT:R-XTR-5687484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Xenopus tropicalis)
REACT:R-CEL-9646348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Caenorhabditis elegans)
REACT:R-DME-9674093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type I TKI (Drosophila melanogaster)
RHEA:23316	skos:prefLabel	"pyrimidine-deoxynucleoside 1'-dioxygenase"
RHEA:23316	skos:altLabel	"deoxyuridine-uridine 1'-dioxygenase"
RHEA:23316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrimidine-deoxynucleoside 1'-dioxygenase"
RHEA:23316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil
RHEA:23316	skos:altLabel	"pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase"
REACT:R-MMU-170796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports GCK1:GKRP from cytosol to nucleoplasm (Mus musculus)
RHEA:10843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-homoserine <=> L-threonine + phosphate
REACT:R-XTR-383373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 3 (NK3) binds to neurokinin B (Xenopus tropicalis)
RHEA:51880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,6-trichlorocatechol + O2 = (2Z,4E)-2,3,5-trichloromuconate + H(+)
REACT:R-RNO-388828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PD-1 binds B7DC and B7H1 (Rattus norvegicus)
RHEA:61071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + horhammericine <=> 19-O-acetylhorhammericine + CoA
RHEA:70235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside
REACT:R-GGA-5696655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 PARylates DDB2 and autoPARylates (Gallus gallus)
REACT:R-SSC-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Sus scrofa)
REACT:R-BTA-6798373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates DYRK2 (Bos taurus)
GO:0003913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA photolyase activity
RHEA:71228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + selenocyanate(out) => 2 Na(+)(in) + selenocyanate(in)
REACT:R-HSA-2395322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyridinoline cross-links (Homo sapiens)
REACT:R-HSA-430158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds VAV (Homo sapiens)
RHEA:66775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + uroporphyrin I(in) <=> ADP + H(+) + phosphate + uroporphyrin I(out)
REACT:R-DME-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Drosophila melanogaster)
RHEA:62235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine(6-4)thymidine in DNA <=> a thymidine dimer in DNA
GO:0050394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + viomycin = ADP + H(+) + O-phosphoviomycin
GO:0050394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:viomycin O-phosphotransferase activity
GO:0050394	skos:prefLabel	"viomycin kinase"
GO:0050394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	capreomycin phosphotransferase activity
GO:0050394	skos:altLabel	"capreomycin phosphotransferase"
GO:0050394	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	viomycin phosphotransferase activity
GO:0050394	skos:altLabel	"viomycin phosphotransferase"
GO:0050394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"viomycin kinase"
GO:0050394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viomycin kinase activity
REACT:R-BTA-6804425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F2 (Bos taurus)
REACT:R-BTA-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Bos taurus)
RHEA:38843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine
RHEA:61052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8953115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds to MGA:MAX (Homo sapiens)
REACT:R-RNO-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Rattus norvegicus)
REACT:R-RNO-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)
REACT:R-SSC-190681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin oligomerization in endoplasmic reticulum membrane (Sus scrofa)
RHEA:17763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + H(+) + NADPH => an aromatic primary alcohol + NADP(+)
RHEA:62599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-8-oxocitronellyl enol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH
RHEA:32966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate + H2O <=> 2-oxoglutarate + NH4(+)
REACT:R-HSA-9759169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Homo sapiens)
EC:4.1.3.-	skos:prefLabel	"Oxo-acid-lyases"
EC:4.1.3.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Oxo-acid-lyases"
REACT:R-SCE-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Saccharomyces cerevisiae)
RHEA:28983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite(in) = nitrite(out)
RHEA:36389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6''-O-carbamoylkanamycin A + AMP + H(+) => carbamoyl adenylate + kanamycin A
REACT:R-DRE-2028294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Danio rerio)
REACT:R-BTA-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Bos taurus)
REACT:R-HSA-6790907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides (Homo sapiens)
GO:0015475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adhesin autotransporter activity
GO:0102978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	furaneol oxidoreductase activity
RHEA:24614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + H(+) + NADH => 17beta-estradiol + NAD(+)
RHEA:53108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine
RHEA:20535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + pyridoxal => H2O + pyridoxal 5'-phosphate
RHEA:42968	skos:prefLabel	"tRNA (cytidine(56)-2'-O)-methyltransferase"
RHEA:42968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:42968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (cytidine(56)-2'-O)-methyltransferase"
REACT:R-CEL-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
RHEA:27797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 4 diphosphate
REACT:R-CEL-9650473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 is secreted (Caenorhabditis elegans)
REACT:R-RNO-2404131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Rattus norvegicus)
REACT:R-HSA-433725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Afadin with F-actin (Homo sapiens)
RHEA:28169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-nitroanthranilate + H(+) + H2O <=> 5-nitrosalicylate + NH4(+)
RHEA:27934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-D-aspartate = glycine + glyoxylate
RHEA:27934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-D-aspartate aldolase"
RHEA:27934	skos:prefLabel	"3-hydroxy-D-aspartate aldolase"
RHEA:27934	skos:altLabel	"D-3-hydroxyaspartate aldolase"
RHEA:27934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-D-aspartate = glycine + glyoxylate
REACT:R-BTA-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)
GO:0035403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone threonine kinase activity (H3-T6 specific)
GO:0035403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H3-T6 specific)
GO:0035403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-T6 kinase activity
GO:0035403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3T6 kinase activity
GO:0035403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-threonine kinase activity (H3-T6 specific)
REACT:R-RNO-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Rattus norvegicus)
RHEA:62491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-RNO-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Rattus norvegicus)
REACT:R-RNO-2471842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XXV ectomain shedding (Rattus norvegicus)
REACT:R-DRE-8954468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Danio rerio)
REACT:R-DDI-351208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermidine  => N-acetylated spermidine (Dictyostelium discoideum)
REACT:R-CFA-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Canis familiaris)
REACT:R-GGA-202917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 1 (Gallus gallus)
REACT:R-MMU-8983876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT4 binds IL12RB2:IL12RB2 (Mus musculus)
RHEA:21357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NAD(+) => H(+) + L-ribulose + NADH
REACT:R-SSC-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Sus scrofa)
RHEA:22230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + NAD(+) + squalene => H(+) + NADH + presqualene diphosphate
REACT:R-BTA-204873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shp2 (Bos taurus)
REACT:R-BTA-8944232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XII (Bos taurus)
REACT:R-GGA-3928641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK binds RAC and bPIX (Gallus gallus)
RHEA:38407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)
REACT:R-HSA-8940554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2 cleaves OPTC (Homo sapiens)
RHEA:39322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)
RHEA:58201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 6-aminohexanoate => 6-oxohexanoate + L-glutamate
RHEA:28690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + ubiquinone-8 <=> orotate + ubiquinol-8
REACT:R-RNO-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Rattus norvegicus)
REACT:R-HSA-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Homo sapiens)
REACT:R-RNO-389826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NADPH + H+ => glycolate + NADP+ (Rattus norvegicus)
RHEA:47096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate
RHEA:47096	skos:prefLabel	"trans,polycis-decaprenyl diphosphate synthase"
RHEA:47096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans,polycis-decaprenyl diphosphate synthase"
RHEA:47096	skos:altLabel	"(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase"
GO:0031418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbic acid binding
GO:0031418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate binding
GO:0031418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin C binding
EC:3.5.1.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acyl-aliphatic-L-amino acid amidohydrolase"
EC:3.5.1.14	skos:altLabel	"benzamidase"
EC:3.5.1.14	skos:altLabel	"dehydropeptidase II"
EC:3.5.1.14	skos:altLabel	"acylase I"
EC:3.5.1.14	skos:altLabel	"aminoacylase I"
EC:3.5.1.14	skos:altLabel	"N-acyl-L-amino-acid amidohydrolase"
EC:3.5.1.14	skos:altLabel	"histozyme"
EC:3.5.1.14	skos:prefLabel	"N-acyl-aliphatic-L-amino acid amidohydrolase"
EC:3.5.1.14	skos:altLabel	"aminoacylase 1"
EC:3.5.1.14	skos:altLabel	"hippuricase"
REACT:R-HSA-4341025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)
REACT:R-BTA-879562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Bos taurus)
REACT:R-SSC-9021068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs bind CAVs (Sus scrofa)
RHEA:71169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(in) + H(+)(out) + Na(+)(in) => glycine(out) + H(+)(in) + Na(+)(out)
REACT:R-MMU-9650473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 is secreted (Mus musculus)
RHEA:30705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + phenol => H(+) + salicylate
REACT:R-HSA-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Homo sapiens)
REACT:R-BTA-9724685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds omalizumab (Bos taurus)
REACT:R-MMU-5668629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Mus musculus)
RHEA:13423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylneuraminate 9-phosphate + phosphate => an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate
RHEA:66470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17E)-cheilanthenediol => (2E,6E,10E,14E)-geranylfarnesol + H2O
RHEA:70080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + clavatol + O2 => CO2 + hydroxyclavatol + succinate
RHEA:62066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH => 2-deoxy-D-glucose 6-phosphate + NAD(+)
REACT:R-MMU-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Mus musculus)
RHEA:62061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)
RHEA:43753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]
RHEA:40534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:54502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-geranylfarnesene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate
REACT:R-GGA-5686900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 recruits DCLRE1C to ATM (Gallus gallus)
RHEA:42636	skos:altLabel	"MoCo sulfurase"
RHEA:42636	skos:altLabel	"MoCo sulfurtransferase"
RHEA:42636	skos:prefLabel	"molybdenum cofactor sulfurtransferase"
RHEA:42636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"molybdenum cofactor sulfurtransferase"
RHEA:42636	skos:altLabel	"molybdenum cofactor sulfurase"
RHEA:42636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin
RHEA:61196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
REACT:R-CEL-373730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin and NrCAM heterodimerization (Caenorhabditis elegans)
RHEA:55412	skos:altLabel	"polyphosphate kinase 2"
RHEA:55412	skos:prefLabel	"GDP-polyphosphate phosphotransferase"
RHEA:55412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-polyphosphate phosphotransferase"
RHEA:55412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + GTP = [phosphate](n+1) + GDP
REACT:R-HSA-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Homo sapiens)
REACT:R-CFA-390438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR2 reduces PalmCoA to HXOL (Canis familiaris)
REACT:R-XTR-451634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
REACT:R-MMU-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Mus musculus)
RHEA:39581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA
REACT:R-DRE-8855617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Danio rerio)
REACT:R-HSA-5617462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXD1 gene is transcribed (Homo sapiens)
REACT:R-GGA-9658445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Gallus gallus)
REACT:R-CFA-8938121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds CTSK (Canis familiaris)
RHEA:35528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-ethylmaleimide + NADH => N-ethylsuccinimide + NAD(+)
REACT:R-HSA-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
REACT:R-CFA-5678261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Canis familiaris)
RHEA:21722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hydrogen cyanide => formamide
REACT:R-DRE-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Danio rerio)
RHEA:37609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate
RHEA:36630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxytetracosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine
REACT:R-GGA-5653838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE binds deISGylated PCNA after TLS (Gallus gallus)
REACT:R-HSA-1791071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PLA2G4B (Homo sapiens)
REACT:R-HSA-2022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)
REACT:R-XTR-205321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of KIT and sSCF (Xenopus tropicalis)
RHEA:14841	skos:altLabel	"ent-kaurene synthase A"
RHEA:14841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = ent-copalyl diphosphate
RHEA:14841	skos:altLabel	"ent-CDP synthase"
RHEA:14841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-copalyl diphosphate synthase"
RHEA:14841	skos:prefLabel	"ent-copalyl diphosphate synthase"
RHEA:14841	skos:altLabel	"ent-kaurene synthetase A"
RHEA:24680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + H2O => 5,6,7,8-tetrahydromethanopterin + formaldehyde
REACT:R-SSC-444691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prokineticin receptors bind prokineticin (Sus scrofa)
REACT:R-DRE-159728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-prothrombin to prothrombin (Danio rerio)
REACT:R-DRE-4641350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TOP2A with SUMO2,3 (Danio rerio)
REACT:R-DRE-5635860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Danio rerio)
REACT:R-DME-70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Drosophila melanogaster)
REACT:R-XTR-2530501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FNTA:FNTB transfers FARN to GNGT1 (Xenopus tropicalis)
REACT:R-HSA-446083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)
REACT:R-GGA-5686304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Gallus gallus)
RHEA:14050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol
REACT:R-BTA-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Bos taurus)
RHEA:47497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH
REACT:R-CFA-5666197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds LIN7B (Canis familiaris)
RHEA:36715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + tetracosenoyl-CoA = an N-tetracosenoylsphinganine + CoA + H(+)
RHEA:34246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin guanine dinucleotide
RHEA:31373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine => (2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine
RHEA:38729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol
REACT:R-RNO-391372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRH1,2 (Rattus norvegicus)
RHEA:14549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxymuconate-6-semialdehyde hydrolase"
RHEA:14549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + formate + H(+)
RHEA:14549	skos:altLabel	"2-hydroxymuconate-semialdehyde hydrolase"
RHEA:14549	skos:prefLabel	"2-hydroxymuconate-6-semialdehyde hydrolase"
RHEA:48444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol
REACT:R-SSC-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Sus scrofa)
RHEA:70058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cremeomycin <=> 2-hydroxy-4-methoxybenzoate + A + N2
RHEA:67431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)
REACT:R-HSA-6799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates TP53 (Homo sapiens)
GO:0080150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity
GO:0080150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity
REACT:R-CEL-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Caenorhabditis elegans)
REACT:R-SSC-8985973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Sus scrofa)
REACT:R-HSA-2187332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic CMs translocate to extracellular region (Homo sapiens)
REACT:R-DME-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Drosophila melanogaster)
RHEA:16437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione transferase"
RHEA:16437	skos:altLabel	"glutathione S-alkyltransferase"
RHEA:16437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
RHEA:16437	skos:prefLabel	"glutathione transferase"
RHEA:16437	skos:altLabel	"glutathione S-aryltransferase"
RHEA:16437	skos:altLabel	"glutathione S-aralkyltransferase"
RHEA:16437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + RX = a halide anion + an S-substituted glutathione + H(+)
RHEA:16437	skos:altLabel	"S-(hydroxyalkyl)glutathione lyase"
REACT:R-HSA-5610752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R translocates to the nucleus (Homo sapiens)
RHEA:67162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'-chloromelleolide F + FAD + H(+) + 2 H2O => chloride + FADH2 + melleolide F + O2
RHEA:11708	skos:altLabel	"inosine 5'-monophosphate dehydrogenase"
RHEA:11708	skos:prefLabel	"IMP dehydrogenase"
RHEA:11708	skos:altLabel	"IMP oxidoreductase"
RHEA:11708	skos:altLabel	"inosinate dehydrogenase"
RHEA:11708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP + NAD(+) = H(+) + NADH + XMP
RHEA:11708	skos:altLabel	"inosine monophosphate oxidoreductase"
RHEA:11708	skos:altLabel	"inosinic acid dehydrogenase"
RHEA:11708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"IMP dehydrogenase"
RHEA:45473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate
RHEA:60738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesoate + 2 H(+) + NADPH => (2E,6E)-farnesal + H2O + NADP(+)
RHEA:18483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexylamine + sulfate => cyclohexylsulfamate + H2O
REACT:R-HSA-2160915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor-mediated uptake of HA (Homo sapiens)
GO:0047511	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methylmalonyl-coenzyme A hydrolase activity
GO:0047511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA hydrolase activity
REACT:R-HSA-9664397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgG binds LPG1G2 in the amastigote form of Leishmania (Homo sapiens)
REACT:R-CEL-1369052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid influx (Caenorhabditis elegans)
RHEA:47425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-octadecadienoyl-CoA + H2O => (3S)-hydroxy-(9Z-octadecenoyl)-CoA
RHEA:61443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + S-(2-succino)-L-cysteine <=> CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine
REACT:R-SSC-177933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by phosphorylated EGFR (Sus scrofa)
REACT:R-SSC-5649658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves DHU from damaged DNA (Sus scrofa)
RHEA:42048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH
REACT:R-XTR-75883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHRS7B reduces GO3P to HXDG3P (Xenopus tropicalis)
REACT:R-XTR-688137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 is K63 polyubiquitinated (Xenopus tropicalis)
RHEA:11388	skos:prefLabel	"11beta-hydroxysteroid dehydrogenase"
RHEA:11388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH
RHEA:11388	skos:altLabel	"corticosteroid 11beta-dehydrogenase"
RHEA:11388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"11beta-hydroxysteroid dehydrogenase"
REACT:R-RNO-6800868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDUF subunits bind to form the IP subcomplex (Rattus norvegicus)
RHEA:62185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peregrinol diphosphate => diphosphate + labd-13(16),14-diene-9-ol
REACT:R-CEL-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)
REACT:R-DRE-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Danio rerio)
RHEA:37495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
GO:0034822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citronellal dehydrogenase activity
REACT:R-HSA-5669250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates FLNA (Homo sapiens)
REACT:R-CFA-1676162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Canis familiaris)
RHEA:26311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O
REACT:R-DDI-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Dictyostelium discoideum)
RHEA:40685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol
RHEA:51060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androst-1-ene-3,17-dione + A = AH2 + androsta-1,4-diene-3,17-dione
REACT:R-BTA-9692867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds pitosilant (Bos taurus)
REACT:R-CEL-5638016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2:ARL3:GDP:UNC119B dissociates (Caenorhabditis elegans)
REACT:R-XTR-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Xenopus tropicalis)
RHEA:71575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphomethyl-dUMP in DNA + putrescine = 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate
REACT:R-DME-209358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription (Drosophila melanogaster)
RHEA:46776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:46776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sn-1 oleoyl-lipid 12-desaturase"
RHEA:46776	skos:prefLabel	"sn-1 oleoyl-lipid 12-desaturase"
REACT:R-BTA-9009526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Bos taurus)
REACT:R-RNO-5678261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-HSA-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Homo sapiens)
REACT:R-XTR-8854612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 accelerates GTP hydrolysis by RAB33B (Xenopus tropicalis)
RHEA:62417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + H2O => 4-hydroxybenzaldehyde + acetyl-CoA
RHEA:51776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlorisobutanophenone + dimethylallyl diphosphate = deoxycohumulone + diphosphate
RHEA:34967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate(in) = sn-glycerol 3-phosphate(out)
GO:0106413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrouridine synthase activity
REACT:R-CFA-6788999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HV1-mediated H+ transfer (Canis familiaris)
REACT:R-DME-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Drosophila melanogaster)
RHEA:69449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => delta-cadinol + diphosphate
REACT:R-RNO-5229283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCNs bind lipids (Rattus norvegicus)
RHEA:32829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + methionine(in) + phosphate => ATP + H2O + methionine(out)
GO:0033251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cephalosporinase activity
REACT:R-SSC-198955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR complex interacts with peptide antigen-presenting MHC Class I (Sus scrofa)
REACT:R-CFA-8850794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK5 (Canis familiaris)
REACT:R-XTR-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Xenopus tropicalis)
GO:0018505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-cis-naphthalene dihydrodiol dehydrogenase activity
GO:0018505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-dihydrodiol naphthalene dehydrogenase activity
GO:0018505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	naphthalene dihydrodiol dehydrogenase activity
GO:0018505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-naphthalene dihydrodiol dehydrogenase activity
GO:0018505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity
GO:0018505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity
GO:0018505	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity
REACT:R-XTR-174235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdc20 (Xenopus tropicalis)
RHEA:62741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2
REACT:R-BTA-191784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA Cap hypermethylation (Bos taurus)
REACT:R-BTA-74707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IRS to insulin receptor (Bos taurus)
REACT:R-MMU-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Mus musculus)
REACT:R-RNO-1793209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses Chondroitin chains (Rattus norvegicus)
RHEA:19102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-butyne-1,4-diol + NAD(+) => 4-hydroxy-2-butynal + H(+) + NADH
REACT:R-MMU-445714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-3 passively transports water out of cell (Mus musculus)
REACT:R-SSC-3321883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSL acetylates histone H4 (Sus scrofa)
REACT:R-CFA-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)
REACT:R-DRE-8932955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-RNO-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Rattus norvegicus)
REACT:R-CFA-71275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + glycine => ornithine + guanidoacetate (Canis familiaris)
RHEA:68390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 indole-5,6-quinone-2-carboxylate => 2 5,6-dihydroxyindole-2-carboxylate + O2
REACT:R-DME-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Drosophila melanogaster)
REACT:R-DDI-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Dictyostelium discoideum)
REACT:R-HSA-373867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Homo sapiens)
REACT:R-GGA-6798257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRS binds NTRK3 (Gallus gallus)
REACT:R-DRE-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Danio rerio)
REACT:R-SSC-388832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds CD28 (Sus scrofa)
RHEA:37750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine <=> 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-5666216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds TAX1BP3 (Canis familiaris)
RHEA:24277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + diphosphate => acetyl phosphate + phosphate
RHEA:15973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)
RHEA:15973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"estrone sulfotransferase"
RHEA:15973	skos:prefLabel	"estrone sulfotransferase"
RHEA:14174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-tryptophan => 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate
REACT:R-XTR-6800200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-HGF to form HGF dimer (Xenopus tropicalis)
RHEA:28676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose => beta-D-galactose
REACT:R-MMU-5339535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTPD1 transports C1P from plasma membrane to Golgi membrane (Mus musculus)
REACT:R-RNO-5651723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Rattus norvegicus)
REACT:R-DRE-193696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Danio rerio)
GO:0009917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol 5-alpha reductase activity
REACT:R-HSA-5655262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 point, translocation and fusion mutants bind FRS2 (Homo sapiens)
REACT:R-DRE-2327909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN binds collagen I, II, III, VI fibrils (Danio rerio)
GO:0047677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arachidonate:oxygen 8-oxidoreductase activity
GO:0047677	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	8-lipoxygenase activity
GO:0047677	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arachidonate 8-lipoxygenase activity
GO:0047677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonate 8(R)-lipoxygenase activity
GO:0047677	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	8(R)-lipoxygenase activity
EC:3.4.24.59	skos:prefLabel	"mitochondrial intermediate peptidase"
EC:3.4.24.59	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mitochondrial intermediate peptidase"
RHEA:48676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:50178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2
GO:0047656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose phosphorylase activity
GO:0047656	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	trehalose phosphorylase
GO:0047656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a,a-trehalose phosphorylase activity
GO:0047656	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity
GO:0008603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity
GO:0008603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP-dependent protein kinase regulator activity
GO:0008603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5' cAMP-dependent protein kinase regulator activity
GO:0008603	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cAMP-dependent protein kinase, intrinsic regulator activity
GO:0008603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic AMP-dependent protein kinase regulator activity
GO:0008603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cAMP-dependent protein kinase regulator activity
REACT:R-XTR-4551679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO2 (Xenopus tropicalis)
RHEA:25630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin + S-adenosyl-L-methionine => H(+) + laricitrin + S-adenosyl-L-homocysteine
REACT:R-HSA-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
RHEA:47044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnitine + acetyl-CoA = acetoacetate + N,N,N-trimethylglycyl-CoA
RHEA:49185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H(+) + H2O => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol
REACT:R-DRE-5694421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6 dephosphorylates SEC24 (Danio rerio)
REACT:R-MMU-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Mus musculus)
REACT:R-HSA-5684006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translocates NBN to the nucleus (Homo sapiens)
REACT:R-DRE-5625745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 stimulates association of AR with NCOA2 (Danio rerio)
REACT:R-BTA-1855205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)
REACT:R-HSA-389955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-tubulin:GTP: Cofactor A+ Cofactor D ->  Beta-tubulin:GTP:Cofactor D + Cofactor A (Homo sapiens)
REACT:R-RNO-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Rattus norvegicus)
RHEA:59978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + toluene => 2-phenylacetate + H(+)
RHEA:43660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + propanoyl-CoA = ADP + H(+) + methylmalonyl-CoA + phosphate
REACT:R-HSA-6809720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM1:MTMR12 (Homo sapiens)
RHEA:55176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + butanoyl-CoA + O2 = 2-hydroxybutanoyl-CoA + CO2 + succinate
REACT:R-SSC-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Sus scrofa)
REACT:R-CFA-416690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4A binds to PLXND1 (Canis familiaris)
REACT:R-XTR-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Xenopus tropicalis)
REACT:R-MMU-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Mus musculus)
RHEA:11838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine
GO:0032548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrimidine deoxyribonucleoside binding
REACT:R-DME-1006143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C3b (Drosophila melanogaster)
RHEA:24085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
EC:3.2.1.55	skos:altLabel	"arabinofuranosidase"
EC:3.2.1.55	skos:prefLabel	"non-reducing end alpha-L-arabinofuranosidase"
EC:3.2.1.55	skos:altLabel	"alpha-L-arabinofuranosidase"
EC:3.2.1.55	skos:altLabel	"arabinosidase"
EC:3.2.1.55	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"non-reducing end alpha-L-arabinofuranosidase"
RHEA:21355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)
REACT:R-DRE-8848864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARAP1 (Danio rerio)
RHEA:46948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + S-adenosyl-L-methionine = N(7)-methyl-GTP + S-adenosyl-L-homocysteine
RHEA:24704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose => NAD(+) + UDP-alpha-D-glucuronate
RHEA:32356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + 2 UDP
RHEA:29279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-8 + trimethylamine N-oxide = H2O + menaquinone-8 + trimethylamine
RHEA:71528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine(out) => thymine(in)
RHEA:39984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:56416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosylglycerol phosphorylase (configuration-retaining)"
RHEA:56416	skos:prefLabel	"glucosylglycerol phosphorylase (configuration-retaining)"
RHEA:56416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = alpha-D-glucose 1-phosphate + glycerol
RHEA:56416	skos:altLabel	"2-O-alpha-D-glucosylglycerol phosphorylase (retaining)"
REACT:R-DME-5674373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPK at the Golgi membrane (Drosophila melanogaster)
REACT:R-BTA-110221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by SMUG1 glycosylase (Bos taurus)
REACT:R-MMU-1433423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP-RO interacts with p-c-Kit complex (Mus musculus)
REACT:R-CFA-2172433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIX degradation (Canis familiaris)
REACT:R-BTA-453183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y348-SYK dissociates (Bos taurus)
REACT:R-MMU-997326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Mus musculus)
RHEA:45223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] <=> Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-HSA-432195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Homo sapiens)
GO:0090560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3-amino-3-carboxypropyl)histidine synthase activity
REACT:R-BTA-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Bos taurus)
REACT:R-MMU-975147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Mus musculus)
RHEA:15710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + UDP-alpha-D-galactose => H(+) + kaempferol 3-O-beta-D-galactoside + UDP
RHEA:39650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)
RHEA:53671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
RHEA:72327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate = 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
REACT:R-HSA-8984021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Homo sapiens)
REACT:R-CEL-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Caenorhabditis elegans)
REACT:R-GGA-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Gallus gallus)
RHEA:62111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:23171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coformycin + NADP(+) <=> 8-oxocoformycin + H(+) + NADPH
REACT:R-PFA-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Plasmodium falciparum)
RHEA:31666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-N-acetylbacillosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
RHEA:47128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + deoxycholate = AMP + deoxycholoyl-CoA + diphosphate
REACT:R-GGA-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Gallus gallus)
RHEA:51556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-glaucine + S-adenosyl-L-methionine = (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
RHEA:57451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-tyrosine + tRNA(Tyr) <=> AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)
RHEA:13643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methanol + NADP(+) => H(+) + methane + NADPH + O2
REACT:R-BTA-8850961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREX2 binds PTEN and inhibits it (Bos taurus)
RHEA:57579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-191656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Closure of gap junction (Homo sapiens)
RHEA:61637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + isophthalate => AMP + diphosphate + isophthalyl-CoA
RHEA:50905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine
REACT:R-HSA-176609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + PAPS => cholesterol sulfate + PAP (Homo sapiens)
RHEA:33267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+) = 2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+)
REACT:R-SSC-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Sus scrofa)
RHEA:32831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an R-cob(III)alamin(in) = an R-cob(III)alamin(out)
RHEA:45355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxyoctadecanoate + H2O <=> 9,10-dihydroxyoctadecanoate
REACT:R-DME-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Drosophila melanogaster)
RHEA:12662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine
REACT:R-DDI-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Dictyostelium discoideum)
REACT:R-SSC-193460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Sus scrofa)
RHEA:11060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
RHEA:11060	skos:prefLabel	"isoleucine--tRNA ligase"
RHEA:11060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoleucine--tRNA ligase"
RHEA:11060	skos:altLabel	"isoleucine translase"
RHEA:11060	skos:altLabel	"isoleucyl-tRNA synthetase"
RHEA:60511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in mRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine
REACT:R-CFA-5654628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS3 (Canis familiaris)
RHEA:50622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose
REACT:R-RNO-5693615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Rattus norvegicus)
REACT:R-SSC-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Sus scrofa)
REACT:R-CEL-177934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR autophosphorylation (Caenorhabditis elegans)
REACT:R-CFA-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Canis familiaris)
GO:0036479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxidase inhibitor activity
REACT:R-RNO-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Rattus norvegicus)
GO:0004518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclease activity
REACT:R-DRE-4615987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO2,3 (Danio rerio)
RHEA:64784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-ethyl-L-cysteine = 2-aminoprop-2-enoate + ethanethiol
REACT:R-BTA-74718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalisation of the insulin receptor (Bos taurus)
RHEA:66763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + kainate(in) <=> ADP + H(+) + kainate(out) + phosphate
RHEA:44920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)
REACT:R-XTR-4420121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate PLCG1 (Xenopus tropicalis)
REACT:R-CFA-9680443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,2 bind ROCKi (Canis familiaris)
REACT:R-MMU-200424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Mus musculus)
RHEA:72078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine <=> ADP + H(+) + ophthalmate + phosphate
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	methyl viologen-nitrite reductase activity
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[nitrite reductase (cytochrome)]
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NO-forming nitrite reductase activity
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c-551:O2, NO2+ oxidoreductase activity
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitric-oxide:ferricytochrome-c oxidoreductase activity
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome cd1 activity
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite reductase (cytochrome; NO-forming) activity
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome cd activity
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cd-cytochrome nitrite reductase activity
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite reductase (NO-forming) activity
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NO-forming nitrite reductase (cytochrome) activity
GO:0050421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c-551:O2, NO2(+) oxidoreductase activity
REACT:R-CFA-163756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of fatty acid synthase (FAS) dimer (Canis familiaris)
RHEA:68875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + ATP + H(+) + NADPH <=> (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)
RHEA:60958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP => 17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose
REACT:R-GGA-8852010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL2 binds activated T cells surface (Gallus gallus)
RHEA:27699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-galactose + phosphate => beta-L-galactose 1-phosphate + GDP + H(+)
RHEA:70195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + deamido-NAD(+) = ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate
RHEA:67700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)
REACT:R-DRE-114256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS:APAF1 binds procaspase-9 (Danio rerio)
REACT:R-PFA-5623643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH13 reduces atRAL to atROL (Plasmodium falciparum)
REACT:R-CFA-8950518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Canis familiaris)
REACT:R-HSA-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Homo sapiens)
REACT:R-XTR-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Xenopus tropicalis)
REACT:R-XTR-373705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of DCC (Xenopus tropicalis)
RHEA:43963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:13548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0031876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	secretin receptor ligand
GO:0031876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretin receptor binding
RHEA:55838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcitriol + UDP-alpha-D-glucuronate
REACT:R-CEL-2559639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV sulfilimine cross-linking by peroxidasin (Caenorhabditis elegans)
REACT:R-DRE-8948219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3 binds Lysyl hydroxylated collagen propeptides (Danio rerio)
REACT:R-SSC-212252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Sus scrofa)
REACT:R-HSA-6807118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)
RHEA:14691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + chloride + NAD(+) => 4-chlorophenylacetate + NADH + O2
RHEA:67568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + taurochenodeoxycholate = adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate
REACT:R-HSA-3222546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-1 complex stimulates KDM6B transcription (Homo sapiens)
REACT:R-HSA-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Homo sapiens)
RHEA:65330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chrodrimanin H => A + chrodrimanin F
RHEA:42399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-GGA-264997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cysteine to cystine in Proinsulin (Gallus gallus)
REACT:R-DRE-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Danio rerio)
REACT:R-CFA-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-XTR-71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Xenopus tropicalis)
REACT:R-XTR-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Xenopus tropicalis)
REACT:R-GGA-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Gallus gallus)
RHEA:50997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine
REACT:R-CFA-418442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Canis familiaris)
REACT:R-SSC-420173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR1,CRHR2-1 binds CRH,UCN (Sus scrofa)
RHEA:13716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + succinate <=> a ubiquinol + fumarate
REACT:R-DRE-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Danio rerio)
REACT:R-CEL-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Caenorhabditis elegans)
RHEA:52067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)
RHEA:70660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + N,N-dimethylglycine(in) => H(+)(out) + N,N-dimethylglycine(out)
REACT:R-CEL-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Caenorhabditis elegans)
REACT:R-DRE-5625849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM1A binds KLK2 and KLK3 promoters (Danio rerio)
REACT:R-HSA-8957265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades TP73 polyubiquitinated by ITCH (Homo sapiens)
RHEA:36812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + GDP-alpha-D-perosamine => CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)
RHEA:17387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + taurine => H2O + hypotaurine + NAD(+)
RHEA:41947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP
REACT:R-DRE-429732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Danio rerio)
REACT:R-HSA-5663252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors (Homo sapiens)
REACT:R-DME-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Drosophila melanogaster)
REACT:R-HSA-5654633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS bind to PPTN11 (Homo sapiens)
REACT:R-GGA-1562641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)
RHEA:62875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 <=> H2O + NADP(+) + semiviriditoxin
RHEA:38866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sucrose 6(F)-phosphate <=> alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate
RHEA:61969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SCE-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Saccharomyces cerevisiae)
GO:0034738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol O-acyltransferase activity
GO:0047627	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine 5-phosphosulfate sulfohydrolase activity
GO:0047627	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylylsulfate sulfohydrolase activity
GO:0047627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylylsulphatase activity
GO:0047627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylylsulfatase activity
RHEA:49354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:63647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-seryl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)
RHEA:70216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + H(+) + NADPH => 20beta-dihydrocortisol + NADP(+)
RHEA:43065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate => holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate
RHEA:46504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-AMP + holo-[ACP] = AMP + dodecanoyl-[ACP] + H(+)
REACT:R-CFA-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Canis familiaris)
REACT:R-DDI-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Dictyostelium discoideum)
REACT:R-GGA-1474266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibrils (Gallus gallus)
RHEA:70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(in) + H(+)(in) <=> 4-hydroxy-L-proline(out) + H(+)(out)
REACT:R-BTA-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Bos taurus)
REACT:R-MMU-1675994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Mus musculus)
RHEA:67369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-glutamine => acetate + L-glutamine
REACT:R-MMU-1236954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides by IRAP in endocytic vesicles (Mus musculus)
RHEA:39649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+) => AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine
RHEA:10082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,5-trihydroxybenzene + NADPH => dihydrophloroglucinol + NADP(+)
RHEA:61644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + L-arginine
RHEA:49487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate
REACT:R-SPO-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Schizosaccharomyces pombe)
REACT:R-SSC-194689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Sus scrofa)
GO:0036381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
GO:0036381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PdxST activity
GO:0036381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) activity
REACT:R-RNO-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Rattus norvegicus)
REACT:R-XTR-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Xenopus tropicalis)
GO:0097641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + xanthine = CO2 + succinate + urate
GO:0097641	skos:prefLabel	"xanthine dioxygenase"
GO:0097641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutarate- and Fe(II)-dependent xanthine hydroxylase activity
GO:0097641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate-dependent xanthine dioxygenase activity
GO:0097641	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutarate- and Fe(II)-dependent xanthine dioxygenase activity
GO:0097641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate-dependent xanthine dioxygenase activity
GO:0097641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xanthine dioxygenase"
GO:0097641	skos:altLabel	"alpha-ketoglutarate-dependent xanthine hydroxylase"
REACT:R-CFA-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Canis familiaris)
REACT:R-MMU-4420140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Mus musculus)
GO:0050383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil dehydrogenase activity
REACT:R-SSC-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Sus scrofa)
RHEA:46699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine <=> an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-6784735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR bind to Clathrin (Danio rerio)
RHEA:64570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ilicicolin H => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one
REACT:R-MMU-390329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of AKT by PP2A (Mus musculus)
REACT:R-HSA-2160892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Homo sapiens)
EC:2.1.5.-	skos:prefLabel	"Methylenetransferases"
EC:2.1.5.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Methylenetransferases"
EC:5.2.1.-	skos:prefLabel	"Cis-trans isomerases"
EC:5.2.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Cis-trans isomerases"
REACT:R-SSC-114671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vWF binds to collagen (Sus scrofa)
REACT:R-SSC-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Sus scrofa)
REACT:R-SSC-9758090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Sus scrofa)
RHEA:52349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CEL-72722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2 activation (Caenorhabditis elegans)
RHEA:49617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanal + H2O + NAD(+) => 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH
REACT:R-SSC-8964241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta-gamma complex and PIP3 recruit BTK to membrane (Sus scrofa)
REACT:R-XTR-6785607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCM binds FAAP24 (Xenopus tropicalis)
RHEA:44116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosan-1-ol + hexadecanoyl-CoA = CoA + eicosanyl hexadecanoate
RHEA:58214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-448744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20RA binds IL20RB (Danio rerio)
REACT:R-HSA-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Homo sapiens)
GO:0140299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small molecule sensor activity
GO:0140299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small molecular sensor activity
GO:0140299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small molecule sensing activity
REACT:R-MMU-453111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
GO:0042469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	versicolorin reductase activity
REACT:R-RNO-1605595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Rattus norvegicus)
REACT:R-CFA-8949668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YME1L1 proteolyzes unassembled proSMDT1 (Canis familiaris)
RHEA:55502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:22961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formononetin + O2 + reduced [NADPH--hemoprotein reductase] => calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:37752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-trans-aconitate => 2-methyl-cis-aconitate
REACT:R-DDI-6804266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TTC5 (Dictyostelium discoideum)
RHEA:53647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether B + diphosphate
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Escherichia coli ribonuclease I' ribonuclease PP2 activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease M activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease T2"
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease (non-base specific) activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase M activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase (non-base specific) activity
GO:0033897	skos:prefLabel	"ribonuclease T2"
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNAase CL activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribonucleate nucleotido-2'-transferase (cyclizing) activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease U4 activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	base-non-specific ribonuclease activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNase II activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Escherichia coli ribonuclease II activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonspecific RNase activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase Ms activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease N2 activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease T2 activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribonuclease II activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleate 3'-oligonucleotide hydrolase activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nonbase-specific RNase activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase T2 activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acid ribonuclease activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acid RNase activity
GO:0033897	skos:altLabel	"ribonuclease II"
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-base specific ribonuclease activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonnuclease (non-base specific) activity
GO:0033897	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease PP3 activity
REACT:R-MMU-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Mus musculus)
RHEA:10521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP
REACT:R-RNO-6788571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3,STAT6 bind IL13:IL13R type II (Rattus norvegicus)
RHEA:16297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3beta-(or 20alpha)-hydroxysteroid dehydrogenase"
RHEA:16297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH
RHEA:16297	skos:altLabel	"3-beta-HSD"
RHEA:16297	skos:altLabel	"progesterone reductase"
RHEA:16297	skos:prefLabel	"3beta-(or 20alpha)-hydroxysteroid dehydrogenase"
RHEA:32761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-methyl-D-ornithine => L-lysine
GO:0090624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoribonuclease activity, cleaving miRNA-paired mRNA
RHEA:55807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)
GO:0102238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geraniol kinase activity (ATP-dependent) activity
RHEA:23067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkanesulfonate + FMNH2 + O2 <=> an aldehyde + FMN + 2 H(+) + H2O + sulfite
RHEA:21639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP
RHEA:72263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + oxalate(in) = chloride(in) + oxalate(out)
RHEA:15177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine
RHEA:15177	skos:prefLabel	"lysophospholipase"
RHEA:15177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysophospholipase"
RHEA:15177	skos:altLabel	"lecithinase B"
RHEA:15177	skos:altLabel	"phospholipase B"
RHEA:15177	skos:altLabel	"lysolecithinase"
RHEA:69174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-butenoate + L-lysyl-[protein] => H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein]
RHEA:29818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-proline(out) <=> ADP + H(+) + L-proline(in) + phosphate
RHEA:22505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate
REACT:R-HSA-1604360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP14 (Homo sapiens)
RHEA:23522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + propanoyl-CoA => acetyl-CoA + propanoate
RHEA:38030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + hydrocaffeoyl-CoA <=> (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate
RHEA:10540	skos:altLabel	"2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase"
RHEA:10540	skos:prefLabel	"dihydroneopterin aldolase"
RHEA:10540	skos:altLabel	"7,8-dihydroneopterin aldolase"
RHEA:10540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroneopterin aldolase"
RHEA:10540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
REACT:R-CEL-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Caenorhabditis elegans)
REACT:R-DRE-174394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSS:Mg2+ dimer synthesizes GSH (Danio rerio)
REACT:R-MMU-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Mus musculus)
RHEA:17247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2 => 3-hydroxyanthranilate + O2
REACT:R-HSA-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Homo sapiens)
RHEA:30746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-riboside + H2O <=> D-ribose + H(+) + nicotinamide
REACT:R-SSC-5684836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC1B dimer binds PDPN (Sus scrofa)
RHEA:51203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine <=> H2O + N-retinylidene-N-retinylphosphatidylethanolamine
REACT:R-SSC-450187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated within the TAK1 complex (Sus scrofa)
RHEA:58967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanal + O2 <=> H(+) + H2O2 + hexanoate
REACT:R-XTR-5423664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 hydroxylates AFB1 to AFQ1 (Xenopus tropicalis)
REACT:R-HSA-451283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kainate receptor binds glutamate (Homo sapiens)
REACT:R-DRE-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Danio rerio)
REACT:R-HSA-5656158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ elongates POLI-incorporated dNMP (Homo sapiens)
GO:0018499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-2,3-dihydrodiol DDT dehydrogenase activity
REACT:R-HSA-2730870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
REACT:R-MMU-9603987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Mus musculus)
REACT:R-DME-445064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by VAV2 (Drosophila melanogaster)
RHEA:50893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + 2 H(+) + hydrogen sulfide + sulfite => a menaquinol + thiosulfate
REACT:R-MMU-1250280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin (Mus musculus)
RHEA:64555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Schizosaccharomyces pombe)
REACT:R-DRE-77271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Danio rerio)
REACT:R-BTA-166726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MASPs (Bos taurus)
REACT:R-CFA-389487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orexin 2 receptor can bind orexin-B neuropeptide (Canis familiaris)
REACT:R-SSC-166387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The FA anion diffuses away laterally from UCP (Sus scrofa)
REACT:R-SSC-507719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62:MEKK3 binds to TRAF6 (Sus scrofa)
REACT:R-CFA-375339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Canis familiaris)
GO:0030604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO:0030604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-deoxyxylulose-5-phosphate reductoisomerase activity
GO:0030604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DXP-reductoisomerase activity
GO:0030604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity
GO:0030604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)
GO:0030604	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-deoxy-D-xylulose-5-phosphate isomeroreductase activity
GO:0030604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOXP reductoisomerase activity
RHEA:69640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phlorizin => beta-D-glucose + phloretin
REACT:R-DRE-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Danio rerio)
RHEA:20565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-endo-fenchol synthase"
RHEA:20565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = (1S,2S,4R)-endo-fenchol + diphosphate
RHEA:20565	skos:prefLabel	"(-)-endo-fenchol synthase"
RHEA:52867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)
RHEA:27456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide + L-tyrosine + NADP(+) <=> 3-iodo-L-tyrosine + NADPH
REACT:R-MMU-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Mus musculus)
REACT:R-HSA-4395236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds promoters of MIR34 genes (Homo sapiens)
REACT:R-CEL-2064421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds ZO-2 (TJP2) (Caenorhabditis elegans)
RHEA:16315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O
REACT:R-CFA-8964317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)
RHEA:67998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chloride + chloroethene + H(+) => (Z)-1,2-dichloroethene + AH2
REACT:R-HSA-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
RHEA:68751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] <=> alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]
GO:0017057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-PGL
GO:0017057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)
GO:0017057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-D-glucono-1,5-lactone lactonohydrolase activity
GO:0017057	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphogluconolactonase activity
GO:0017057	skos:prefLabel	"6-phosphogluconolactonase"
GO:0017057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-phosphogluconolactonase"
GO:0017057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phosphogluconolactonase activity
RHEA:68668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
RHEA:36110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A4 + S-adenosyl-L-methionine <=> O-methyl gibberellin A4 + S-adenosyl-L-homocysteine
RHEA:34480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate => 15-cis-phytoene + diphosphate
REACT:R-RNO-5661116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me3K5-histone H3 (Rattus norvegicus)
REACT:R-SSC-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Sus scrofa)
REACT:R-CFA-2730863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 by PKC-theta (Canis familiaris)
RHEA:46003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H(+) + tuberculosinyl diphosphate <=> 1-tuberculosinyladenosine + diphosphate
REACT:R-CFA-110311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ extends translesion synthesis (Canis familiaris)
RHEA:22872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]
RHEA:22872	skos:altLabel	"procollagen-proline,2-oxoglutarate 3-dioxygenase"
RHEA:22872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"procollagen-proline 3-dioxygenase"
RHEA:22872	skos:altLabel	"proline,2-oxoglutarate 3-dioxygenase"
RHEA:22872	skos:prefLabel	"procollagen-proline 3-dioxygenase"
RHEA:22872	skos:altLabel	"prolyl 3-hydroxylase"
RHEA:44528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)
RHEA:51134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate + a purine nucleobase => a purine 2'-deoxyribonucleoside 5'-phosphate + H2O
REACT:R-HSA-200326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CK octamer] (Homo sapiens)
GO:0008795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deamido-NAD+:ammonia ligase (AMP-forming)
GO:0008795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphopyridine nucleotide synthetase activity
GO:0008795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+ synthetase activity
GO:0008795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD synthetase activity
GO:0008795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(+) synthetase activity
GO:0008795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+ synthase activity
GO:0008795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide adenine dinucleotide synthetase activity
GO:0008795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD synthase activity
GO:0008795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD synthase (AMP-forming)
REACT:R-SSC-4088141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-PPP2R2A dephosphorylates FOXM1 (Sus scrofa)
REACT:R-DME-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Drosophila melanogaster)
REACT:R-CEL-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Caenorhabditis elegans)
RHEA:55494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Bos taurus)
REACT:R-GGA-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Gallus gallus)
REACT:R-XTR-8854899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Xenopus tropicalis)
REACT:R-SSC-9677917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA inhibitors bind MAOA:FAD (Sus scrofa)
RHEA:37516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:33116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(in) => malonate(out)
RHEA:61593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine => 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine
REACT:R-SCE-389639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Saccharomyces cerevisiae)
REACT:R-MMU-5610760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI1 is degraded by the proteasome after ubiquitination by ITCH (Mus musculus)
GO:1904399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan sulfate binding
RHEA:22772	skos:prefLabel	"L-fuconate dehydratase"
RHEA:22772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-fuconate dehydratase"
RHEA:22772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O
RHEA:22486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + GTP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate
GO:2001063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucomannan binding
REACT:R-DME-351936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of claspin (Drosophila melanogaster)
GO:0005372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	water transmembrane transporter activity
REACT:R-BTA-2161768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXA4 is converted to EXC4 by LTC4S (Bos taurus)
REACT:R-MMU-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Mus musculus)
REACT:R-GGA-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Gallus gallus)
REACT:R-XTR-9008052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10(?-152) binds IL1RAPL1 (Xenopus tropicalis)
RHEA:70734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) <=> 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)
REACT:R-CFA-6805546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I binds keratin type II (Canis familiaris)
REACT:R-MMU-606326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HJURP:CENPA complex localizes to the centromere (Mus musculus)
REACT:R-CEL-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
RHEA:18139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-pregnane-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+)
EC:5.4.2.2	skos:prefLabel	"phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)"
EC:5.4.2.2	skos:altLabel	"phosphoglucose mutase"
EC:5.4.2.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)"
EC:5.4.2.2	skos:altLabel	"glucose phosphomutase"
REACT:R-CFA-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Canis familiaris)
GO:1903136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cuprous ion binding
GO:1903136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copper(1+) binding
GO:1903136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(I) binding
GO:1903136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(+) binding
RHEA:50735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) + dehydroepiandrosterone 3-sulfate(in) <=> butanoate(in) + dehydroepiandrosterone 3-sulfate(out)
REACT:R-RNO-9727349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates xanthine to form urate (Rattus norvegicus)
REACT:R-RNO-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Rattus norvegicus)
RHEA:23221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoate + ATP + CoA => 4-chlorobenzoyl-CoA + AMP + diphosphate
RHEA:28475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate(in) + H(+)(in) => D-glucarate(out) + H(+)(out)
RHEA:51047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate imine dimer <=> CO2 + NH4(+) + protodeoxyviolaceinate
RHEA:59182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AMP + H(+) => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O
REACT:R-GGA-2430535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL phosphorylates ENSA (Gallus gallus)
REACT:R-MMU-6807214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Mus musculus)
REACT:R-HSA-1791124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of DNAJB9 (Homo sapiens)
REACT:R-RNO-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Rattus norvegicus)
RHEA:59626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + L-ornithine => H2O + N(2)-(4-aminobutanoyl)-L-ornithine
RHEA:50526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein]
REACT:R-DRE-2466085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from R* to release atRAL (Danio rerio)
GO:0034988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fc-gamma receptor I complex binding
EC:2.4.1.248	skos:prefLabel	"cycloisomaltooligosaccharide glucanotransferase"
EC:2.4.1.248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cycloisomaltooligosaccharide glucanotransferase"
REACT:R-DRE-1433506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APS (Danio rerio)
RHEA:10751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogencarbonate <=> CO2 + H2O
REACT:R-HSA-1112703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 is phosphorylated (Homo sapiens)
REACT:R-RNO-9757574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDL (Rattus norvegicus)
RHEA:51078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate
REACT:R-MMU-2128994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Mus musculus)
RHEA:56721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]
REACT:R-XTR-69299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds geminin (Xenopus tropicalis)
RHEA:30774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + H2O <=> D-ribose + guanine
RHEA:29294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oate + ATP + CoA <=> (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate
REACT:R-DRE-75825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome mediated degradation of Cyclin D1 (Danio rerio)
REACT:R-HSA-6794348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind  SYTs (Homo sapiens)
RHEA:28189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacetone + H2O + O2 <=> H2O2 + methylglyoxal + NH4(+)
GO:0034846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthyl-2-methylene-succinyl-CoA lyase activity
REACT:R-SSC-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Sus scrofa)
RHEA:20942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP
RHEA:44260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA
RHEA:12607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + CO2 => D-glyceraldehyde 3-phosphate + H(+) + pyruvate
REACT:R-MMU-5687673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN recruits LIG3:XRCC1 to MMEJ sites (Mus musculus)
REACT:R-RNO-76397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Rattus norvegicus)
RHEA:26303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin + CO2 => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)
RHEA:43278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GalNAc-GD1a + H(+) + UDP => ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine
RHEA:36465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + L-glutamate => glycyl-L-glutamate + H2O
RHEA:54749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + firefly L-luciferin => AMP + diphosphate + L-firefly luciferyl-CoA
REACT:R-DRE-72143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lariat Formation and 5'-Splice Site Cleavage (Danio rerio)
RHEA:16766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + NADP(+) => D-fructose + H(+) + NADPH
RHEA:50108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + taurine = CoA + H(+) + N-hexadecanoyl-taurine
GO:0103008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chloro-2-methylphenoxyacetate oxygenase activity
EC:3.2.1.201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exo-chitinase (reducing end)"
EC:3.2.1.201	skos:prefLabel	"exo-chitinase (reducing end)"
REACT:R-HSA-193073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Homo sapiens)
RHEA:41503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine
RHEA:23663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propanoate + H2O <=> N-formimidoyl-L-glutamate
REACT:R-GGA-4086036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate NRIP1 with SUMO1 (Gallus gallus)
REACT:R-MMU-9018858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Mus musculus)
REACT:R-CFA-433099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS2 co-transports sulphate and two sodium ions (Canis familiaris)
REACT:R-CFA-432129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds and phosphorylates LRP8 (Canis familiaris)
REACT:R-BTA-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Bos taurus)
REACT:R-DRE-8852509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL-LK binds carbohydrates on target cell surface (Danio rerio)
RHEA:24367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-BTA-9686524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP6-PPP6R3 dephosphorylates TERF2 (Bos taurus)
REACT:R-BTA-5654594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)
REACT:R-MMU-434362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment Of Cytoplasmic Proteins To Vesicles (Mus musculus)
RHEA:31971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)
RHEA:31971	skos:prefLabel	"taxoid 14beta-hydroxylase"
RHEA:31971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taxoid 14beta-hydroxylase"
RHEA:53429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] => a thymidine in DNA + S-methyl-L-cysteinyl-[protein]
RHEA:26039	skos:prefLabel	"mannosylfructose-phosphate synthase"
RHEA:26039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosylfructose-phosphate synthase"
RHEA:26039	skos:altLabel	"MFPS"
RHEA:26039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + GDP-alpha-D-mannose = beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)
RHEA:26039	skos:altLabel	"mannosylfructose-6-phosphate synthase"
RHEA:63277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-CEL-109700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT2 binds PIP3 (Caenorhabditis elegans)
GO:0047993	skos:prefLabel	"hydroxymalonate dehydrogenase"
GO:0047993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymalonate dehydrogenase activity
GO:0047993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymalonate:NAD+ oxidoreductase activity
GO:0047993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxymalonate dehydrogenase"
GO:0047993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate
REACT:R-PFA-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)
REACT:R-BTA-8857577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 facilitates PTK6 autophosphorylation (Bos taurus)
REACT:R-GGA-177933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by phosphorylated EGFR (Gallus gallus)
RHEA:15405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) = [(3R)-hydroxybutanoate](n+1) + CoA
RHEA:38998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + choline + H(+)
EC:1.14.-.-	skos:prefLabel	"Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2"
EC:1.14.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2"
RHEA:69575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + inosine <=> 2'-deoxyinosine + IMP
REACT:R-HSA-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Homo sapiens)
REACT:R-BTA-419001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Bos taurus)
REACT:R-RNO-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Rattus norvegicus)
RHEA:31787	skos:prefLabel	"adenosine tuberculosinyltransferase"
RHEA:31787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tuberculosinyl diphosphate = (13R)-edaxadiene + diphosphate
RHEA:31787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosine tuberculosinyltransferase"
RHEA:37104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)
RHEA:61857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 => betaenone C + 3 H2O + 3 NADP(+)
REACT:R-DME-1878002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLTs transfer Xyl to core protein (Drosophila melanogaster)
REACT:R-BTA-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)
REACT:R-DME-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Drosophila melanogaster)
REACT:R-HSA-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Homo sapiens)
RHEA:37952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate
RHEA:20547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + H2O + NADP(+) => H(+) + L-kynurenine + NADPH + O2
REACT:R-SSC-446870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated TRAF6 binds the TAK1 complex (Sus scrofa)
REACT:R-SSC-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Sus scrofa)
GO:0008349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP4K activity
GO:0008349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP kinase kinase kinase kinase activity
GO:0008349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKKKK
RHEA:43898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Bos taurus)
EC:3.4.24.40	skos:altLabel	"Serratia marcescens extracellular proteinase"
EC:3.4.24.40	skos:altLabel	"Escherichia freundii proteinase"
EC:3.4.24.40	skos:altLabel	"Pseudomonas aeruginosa alkaline protease"
EC:3.4.24.40	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serralysin"
EC:3.4.24.40	skos:prefLabel	"serralysin"
REACT:R-DME-1981128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Drosophila melanogaster)
REACT:R-MMU-5688276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT4 transfers ADPRib to GLUD (Mus musculus)
REACT:R-XTR-420595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-2:Nectin 3 trans heterodimer interaction (Xenopus tropicalis)
RHEA:57499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylcitrate <=> 2-methyl-cis-aconitate + H2O
REACT:R-MMU-9759158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 oligomerizes (Mus musculus)
RHEA:24724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(44)-[F-actin] + NADPH + O2
REACT:R-XTR-5649883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB-mediated DNA strand displacement synthesis (Xenopus tropicalis)
REACT:R-HSA-9724099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)
RHEA:49307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine
REACT:R-BTA-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
REACT:R-HSA-450387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds the CRM1 nuclear export machinery (Homo sapiens)
GO:0008520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sodium-dependent L-ascorbic acid transporter
GO:0008520	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sodium-dependent L-ascorbate transmembrane transporter activity
GO:0008520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate:sodium symporter activity
REACT:R-HSA-191825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of snRNA transcripts (Homo sapiens)
RHEA:42699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hercynylselenocysteine <=> NH4(+) + pyruvate + selnoneine thione
RHEA:34153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxystreptamine + 2-oxoglutaramate => 3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine
GO:0047055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salutaridine synthase activity
GO:0047055	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-reticuline oxidase (C-C phenol-coupling) activity
RHEA:71460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P => L-Leu-L-Met-NH2 + substance P(1-9)
REACT:R-CFA-8950441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Canis familiaris)
RHEA:50452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H3 = prostaglandin E3
REACT:R-DRE-165179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TSC1:TSC2 complex (Danio rerio)
RHEA:67158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:35529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-ethylsuccinimide + NAD(+) => H(+) + N-ethylmaleimide + NADH
REACT:R-GGA-9692809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the ER membrane (Gallus gallus)
REACT:R-HSA-72647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cap-bound mRNA is activated by helicases  (Homo sapiens)
RHEA:40646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)
RHEA:35033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine(out) => L-serine(in)
REACT:R-MMU-433101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Mus musculus)
RHEA:46892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate
RHEA:46892	skos:prefLabel	"8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase"
RHEA:46892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase"
REACT:R-SSC-6788523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to Complex I subunits (Sus scrofa)
RHEA:17946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-5694410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMED2:TMED10 tetramer binds GPI anchored proteins (Xenopus tropicalis)
REACT:R-CFA-450387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds the CRM1 nuclear export machinery (Canis familiaris)
RHEA:10382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + orotate => diphosphate + orotidine 5'-phosphate
REACT:R-RNO-9762343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREDL:ALB dissociates (Rattus norvegicus)
GO:0004493	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmalonyl-CoA racemase activity
GO:0004493	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methyl-3-oxopropanoyl-CoA 2-epimerase activity
GO:0004493	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DL-methylmalonyl-CoA racemase activity
GO:0004493	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmalonyl-CoA 2-epimerase activity
GO:0004493	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmalonyl coenzyme A racemase activity
GO:0004493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl-CoA epimerase activity
REACT:R-DME-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Drosophila melanogaster)
RHEA:40290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + decanedioate <=> AMP + decanedioyl-CoA + diphosphate
REACT:R-CEL-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Caenorhabditis elegans)
REACT:R-CFA-199626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A2/3 transport extracellular THMN to cytosol (Canis familiaris)
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OAT
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine--ketoglutarate aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ornithine 5-aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine--keto acid aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine transaminase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ornithine:2-oxo-acid aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine--oxo acid aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine--2-oxoacid aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine--alpha-ketoglutarate aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine--oxo-acid transaminase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine--keto acid transaminase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine-oxo-acid aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ornithine:alpha-ketoglutarate delta-aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine ketoacid aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine delta-transaminase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine-oxo-acid transaminase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine 5-aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ornithine aminotransferase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ornithine:alpha-oxoglutarate transaminase activity
GO:0004587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GabT
REACT:R-RNO-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)
RHEA:10335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
REACT:R-DME-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Drosophila melanogaster)
RHEA:56438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-SSC-6784006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Sus scrofa)
RHEA:64723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + pyruvate(out) <=> H(+)(in) + pyruvate(in)
REACT:R-HSA-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
RHEA:56055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
RHEA:14221	skos:prefLabel	"monomethyl-sulfatase"
RHEA:14221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monomethyl-sulfatase"
RHEA:14221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + monomethyl sulfate = H(+) + methanol + sulfate
RHEA:56428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:55539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)
REACT:R-BTA-193703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta is activated (Bos taurus)
RHEA:37517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA
REACT:R-MMU-8939706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) polyubiquitinates RUNX2 (Mus musculus)
RHEA:21294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP
RHEA:71485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanyl-L-methionine + L-tyrosylglycylglycine => H2O + Met-enkephalin
REACT:R-XTR-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Xenopus tropicalis)
REACT:R-HSA-8986258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2:ROBO1 binds CXCR4 (Homo sapiens)
REACT:R-BTA-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Bos taurus)
REACT:R-XTR-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Xenopus tropicalis)
GO:0047513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity
GO:0047513	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	almond emulsin fucosidase II activity
GO:0047513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-alpha-L-fucosidase activity
GO:0047513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	almond emulsin fucosidase activity
GO:0047513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-(1->2)-L-fucosidase activity
REACT:R-HSA-5684250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Homo sapiens)
REACT:R-MMU-4641249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Mus musculus)
REACT:R-DRE-9709454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR binds EPOR agonists (Danio rerio)
RHEA:47826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octadecanoyl-[ACP]
REACT:R-MMU-374173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR1 (Mus musculus)
REACT:R-SSC-5690023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL binds 4Fe-4S (Sus scrofa)
REACT:R-BTA-8955285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Bos taurus)
REACT:R-PFA-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)
RHEA:56214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-HSA-5602080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Homo sapiens)
RHEA:55061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-446200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLPP1 dephosphorylates DOLDP to DOLP (Canis familiaris)
REACT:R-MMU-216756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)
GO:0047463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-amino-epsilon-caprolactam racemase activity
GO:0047463	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-hexano-6-lactam racemase activity
GO:0047463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminohexano-6-lactam racemase activity
RHEA:64751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate
RHEA:68660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Homo sapiens)
RHEA:11295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + rifamycin B <=> H2O2 + rifamycin O
RHEA:34168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypseudooxynicotine + H2O => 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)
REACT:R-GGA-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)
REACT:R-DRE-9018863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Danio rerio)
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I IFN receptor activity
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-alpha receptor activity
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-tau receptor activity
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-epsilon receptor activity
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-beta receptor activity
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-delta receptor activity
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-omega receptor activity
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-kappa receptor activity
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type I interferon receptor activity
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-alpha/beta receptor activity
GO:0004905	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interferon-zeta receptor activity
RHEA:59454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + H(+) + NADPH => a long-chain primary fatty alcohol + NADP(+)
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoric monoester hydrolase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	NPPase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-nitrophenylphosphate phosphohydrolase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatase
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	4-nitrophenylphosphate phosphohydrolase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PNPPase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	K-pNPPase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	para-nitrophenyl phosphatase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nitrophenyl phosphatase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-nitrophenylphosphatase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	4-nitrophenylphosphatase activity
GO:0016791	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ecto-p-nitrophenyl phosphatase activity
REACT:R-DRE-606326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HJURP:CENPA complex localizes to the centromere (Danio rerio)
REACT:R-SCE-5626507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind F-actin, which is inhibited by calmodulin (Saccharomyces cerevisiae)
REACT:R-GGA-5686072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-3Y-SHC1 dissociates from IGF1R (Gallus gallus)
RHEA:26050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-2187355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters phosphorylated SMAD2/3 (Danio rerio)
REACT:R-BTA-3371422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP70 (Bos taurus)
REACT:R-RNO-1605736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Rattus norvegicus)
RHEA:56130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + diphosphate + flavuxanthin => A + dimethylallyl diphosphate + H2O + nonaflavuxanthin
REACT:R-SSC-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Sus scrofa)
REACT:R-RNO-433101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Rattus norvegicus)
RHEA:56836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine
RHEA:56836	skos:prefLabel	"PqqA peptide cyclase"
RHEA:56836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"PqqA peptide cyclase"
REACT:R-HSA-2730840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Homo sapiens)
REACT:R-BTA-8875540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 recruits CRK,CRKL to MET (Bos taurus)
RHEA:40894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine
REACT:R-HSA-8944250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXV (Homo sapiens)
REACT:R-XTR-388814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds CD28 (Xenopus tropicalis)
RHEA:31704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol
RHEA:41901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] => 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:67497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end CoA-ribonucleoside in mRNA + H2O => 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)
REACT:R-HSA-6807565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNLY is transferred to the phagosome (Homo sapiens)
RHEA:17250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(2+) + 2 H2O + H2O2 => 6 H(+) + 2 iron(III) oxide-hydroxide
REACT:R-RNO-5205672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncleaved Pink1 accumulates in damaged mitochondria (Rattus norvegicus)
RHEA:46439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]
REACT:R-DME-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Drosophila melanogaster)
RHEA:53354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NAD(+)
RHEA:24194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NADP(+)
REACT:R-MMU-5658424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Mus musculus)
RHEA:63239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin <=> 6-O-adenylylstreptomycin + diphosphate
RHEA:47460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(5Z-tetradecenoyl)-CoA + CoA = (3Z)-dodecenoyl-CoA + acetyl-CoA
REACT:R-HSA-8853419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 promotes AURKA autophosphorylation (Homo sapiens)
REACT:R-SSC-9021072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC7, ZDHHC21 palmitoylate ESR1 (Sus scrofa)
REACT:R-GGA-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Gallus gallus)
REACT:R-DME-69063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation (Drosophila melanogaster)
REACT:R-GGA-5323545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Canonical WNT signaling through the atypical receptor RYK (Gallus gallus)
REACT:R-HSA-1912413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH2 mRNA translation controlled by miRNAs (Homo sapiens)
EC:3.2.1.113	skos:altLabel	"mannosidase 1A"
EC:3.2.1.113	skos:altLabel	"Man9-mannosidase"
EC:3.2.1.113	skos:altLabel	"mannosidase 1B"
EC:3.2.1.113	skos:prefLabel	"mannosyl-oligosaccharide 1,2-alpha-mannosidase"
EC:3.2.1.113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannosyl-oligosaccharide 1,2-alpha-mannosidase"
EC:3.2.1.113	skos:altLabel	"ManI"
REACT:R-MMU-5649725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Mus musculus)
REACT:R-CEL-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Caenorhabditis elegans)
REACT:R-GGA-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Gallus gallus)
REACT:R-GGA-6797810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAPL1 (Gallus gallus)
REACT:R-GGA-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Gallus gallus)
REACT:R-RNO-9753676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1,2 acetylate APAP-Cys to APAP-Mer (Rattus norvegicus)
REACT:R-SPO-5618331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC6 deacetylates microtubules (Schizosaccharomyces pombe)
REACT:R-RNO-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Rattus norvegicus)
RHEA:39904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)
REACT:R-DRE-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Danio rerio)
REACT:R-CFA-3322434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP dissociates from ub-TLE (Canis familiaris)
REACT:R-XTR-2022887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 N-deacetylates GlcNAc residues in heparan (Xenopus tropicalis)
RHEA:45468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate
RHEA:45468	skos:altLabel	"lipid A undecaprenyl phosphotransferase"
RHEA:45468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Kdo2-lipid A phosphotransferase"
RHEA:45468	skos:prefLabel	"Kdo2-lipid A phosphotransferase"
RHEA:49350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxospirilloxanthin + H2O => 2,2-dihydroxyspirilloxanthin
REACT:R-DRE-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Danio rerio)
RHEA:10902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic oxo-acid + glycine => an aromatic L-alpha-amino acid + glyoxylate
REACT:R-HSA-380272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plk1-mediated phosphorylation of Nlp (Homo sapiens)
REACT:R-HSA-9698170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Homo sapiens)
REACT:R-DME-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Drosophila melanogaster)
RHEA:69821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + taurine => H(+) + hypotaurine + NADPH + O2
REACT:R-HSA-8866268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADBRK1,2 phosphorylate AVPR2 (Homo sapiens)
GO:0047542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-furoyl-CoA dehydrogenase activity
GO:0047542	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)
GO:0047542	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-furoyl coenzyme A dehydrogenase activity
GO:0047542	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	furoyl-CoA hydroxylase activity
GO:0047542	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)
GO:0047542	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-furoyl coenzyme A hydroxylase activity
RHEA:16232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) <=> a CDP-1,2-diacyl-sn-glycerol + diphosphate
REACT:R-SSC-168915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Sus scrofa)
REACT:R-DDI-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Dictyostelium discoideum)
REACT:R-BTA-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Bos taurus)
REACT:R-MMU-9623384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-agonists bind ADRA1A,B,D (Mus musculus)
REACT:R-DRE-5689861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of XPA and release of CAK  (Danio rerio)
RHEA:54240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-HSA-5622134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRABP1 binds atRA (Homo sapiens)
GO:0004962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endothelin receptor activity
GO:0004962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endothelin-A receptor activity
GO:0004962	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endothelin-B receptor activity
REACT:R-HSA-5368588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL binds CCDC88C (Homo sapiens)
REACT:R-DRE-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Danio rerio)
RHEA:69092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + pentanal = 2 H(+) + NADH + pentanoate
RHEA:44108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + heptanal + NAD(+) = 2 H(+) + heptanoate + NADH
REACT:R-RNO-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Rattus norvegicus)
REACT:R-DRE-9009817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acitretin binds to RAR:RXR (Danio rerio)
REACT:R-CFA-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Canis familiaris)
RHEA:46704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + salicylate = 2-hydroxybenzoyl-5'-AMP + diphosphate
RHEA:61898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone A => betaenone C
RHEA:69740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylsuccinate + succinyl-CoA => 3-phenylsuccinyl-CoA + succinate
REACT:R-GGA-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Gallus gallus)
REACT:R-DDI-2161775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12 oxidises LTA4 to LXA4/B4 (Dictyostelium discoideum)
RHEA:51219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one <=> adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)
REACT:R-MMU-879562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2B1 has a narrow substrate specificity (Mus musculus)
REACT:R-XTR-8852298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Xenopus tropicalis)
REACT:R-HSA-8937134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-27a binds RUNX1 mRNA (Homo sapiens)
GO:0030487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-4,5-bisphosphate 5-phosphatase activity
RHEA:65222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + H(+) + NADPH => (1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+)
RHEA:43171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(34) in tRNA + H(+) + H2O <=> inosine(34) in tRNA + NH4(+)
EC:3.1.2.14	skos:prefLabel	"oleoyl-[acyl-carrier-protein] hydrolase"
EC:3.1.2.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oleoyl-[acyl-carrier-protein] hydrolase"
EC:3.1.2.14	skos:altLabel	"acyl-[acyl-carrier-protein] hydrolase"
EC:3.1.2.14	skos:altLabel	"S-acyl fatty acid synthase thioesterase"
REACT:R-MMU-8852580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clusterin binds C5b-C7, C8, C9 (Mus musculus)
REACT:R-GGA-9013110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC binds effectors at the plasma membrane (Gallus gallus)
RHEA:28031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dGDP + H2O => [thioredoxin]-dithiol + GDP
RHEA:62388	skos:prefLabel	"exo beta-1,2-glucooligosaccharide sophorohydrolase (non-reducing end)"
RHEA:62388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exo beta-1,2-glucooligosaccharide sophorohydrolase (non-reducing end)"
RHEA:62388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n) + H2O = [(1->2)-beta-D-glucosyl](n-2) + sophorose
GO:0033560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate reductase activity
GO:0033560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Homo sapiens)
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine-5'-phosphate pyrophosphorylase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OPRT activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orotate phosphoribosyltransferase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidylic acid phosphorylase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidylic pyrophosphorylase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidylic acid pyrophosphorylase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine monophosphate pyrophosphorylase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine 5'-monophosphate pyrophosphorylase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidylate phosphoribosyltransferase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OPRTase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidylate pyrophosphorylase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidylic phosphorylase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine-5'-phosphate diphosphorylase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotate phosphoribosyl pyrophosphate transferase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotic acid phosphoribosyltransferase activity
GO:0004588	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	orotidine phosphoribosyltransferase activity
REACT:R-BTA-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Bos taurus)
RHEA:45156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA + H(+)
RHEA:44614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine
RHEA:35704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-hydroxyversicolorone + H(+) + NADPH + O2 => (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)
REACT:R-RNO-77299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Rattus norvegicus)
RHEA:42375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-methoxytabersonine + H2O <=> (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine
RHEA:61909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol => 2 AMP + asperphenamate + 2 diphosphate + H(+)
RHEA:34175	skos:prefLabel	"4-hydroxycoumarin synthase"
RHEA:34175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxycoumarin synthase"
RHEA:34175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-CoA + malonyl-CoA = 4-hydroxycoumarin + CO2 + 2 CoA
RHEA:24432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate = acetate + H(+) + oxalate
RHEA:24432	skos:prefLabel	"oxaloacetase"
RHEA:24432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxaloacetase"
RHEA:24432	skos:altLabel	"oxalacetic hydrolase"
REACT:R-CEL-1614544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfite is oxidized to sulfate (Caenorhabditis elegans)
REACT:R-MMU-8857925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Mus musculus)
REACT:R-BTA-390284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + carnitine => propionylcarnitine + CoASH (Bos taurus)
RHEA:16779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + K(+)(in) + phosphate => ATP + H2O + K(+)(out)
GO:0098621	skos:altLabel	"O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase"
GO:0098621	skos:altLabel	"O-phosphoseryl-tRNA(Sec) selenium transferase"
GO:0098621	skos:altLabel	"SepSecS"
GO:0098621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoseryl-selenocysteinyl-tRNA selenium transferase activity
GO:0098621	skos:prefLabel	"O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase"
GO:0098621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase"
GO:0098621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate
RHEA:37769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA
RHEA:46539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:66862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate => dimethylallyl diphosphate + 4 isopentenyl diphosphate
RHEA:68886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+) => 3-hydroxybenzoate + ATP + H(+) + NADPH
RHEA:44283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA
REACT:R-MMU-3215406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds WDR77 (Mus musculus)
RHEA:70220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + H(+) + NADPH => 20beta-dihydrocorticosterone + NADP(+)
RHEA:52138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+) => a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O
REACT:R-HSA-2730888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma (Homo sapiens)
RHEA:28489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(in) <=> Fe(2+)(out)
REACT:R-DRE-706479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated (Danio rerio)
RHEA:41266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prostaglandin A1 <=> 15-oxo-prostaglandin A1 + H(+) + NADH
RHEA:14396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine
REACT:R-SSC-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Sus scrofa)
REACT:R-HSA-3788061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by ADAM8 (Homo sapiens)
REACT:R-MMU-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Mus musculus)
RHEA:34872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol(out) => methanol(in)
REACT:R-XTR-9646679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded proteins bind vimentin to form aggresome (Xenopus tropicalis)
REACT:R-HSA-8866542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)
REACT:R-DDI-5213466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is phosphorylated (Dictyostelium discoideum)
REACT:R-DRE-77614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR1) (Danio rerio)
REACT:R-GGA-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Gallus gallus)
REACT:R-DME-2160935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 ubiquitinates RHOA (Drosophila melanogaster)
REACT:R-DRE-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Danio rerio)
RHEA:54763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide <=> 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate
REACT:R-CFA-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Canis familiaris)
RHEA:58282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic tetraadenylate + 4 diphosphate => 4 ATP
RHEA:14856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoyl-CoA + H2O <=> 4-hydroxybenzoyl-CoA + chloride + H(+)
REACT:R-RNO-9638127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G6P to G1P (Rattus norvegicus)
REACT:R-BTA-3149519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC decyanates CNCbl (Bos taurus)
RHEA:49036	skos:prefLabel	"(-)-pluviatolide 4-O-methyltransferase"
RHEA:49036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-pluviatolide 4-O-methyltransferase"
RHEA:49036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-pluviatolide + S-adenosyl-L-methionine = (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-9670014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor VIIIa dissociates  (Gallus gallus)
RHEA:43823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:30132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoyl-[ACP] => H(+) + holo-[ACP] + octanoate
RHEA:70502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(out) + 2 Na(+)(out) <=> D-galactose(in) + 2 Na(+)(in)
REACT:R-DRE-3095901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1 transports cytosolic RCbl to extracellular region (Danio rerio)
GO:0102865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta6-acyl-lipid desaturase activity
REACT:R-DME-451418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates IRAK1 (Drosophila melanogaster)
RHEA:33180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)
REACT:R-MMU-8983996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Mus musculus)
REACT:R-RNO-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Rattus norvegicus)
RHEA:62681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphtopyrone YWA1 => H(+) + H2O + norrubrofusarin
RHEA:42390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-gentiobiosyl crocetin + H(+) + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose
RHEA:53892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-prenyl-L-cysteine + H2O + O2 = a prenal + H2O2 + L-cysteine
RHEA:30627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + H(+) + NADH
RHEA:29473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose + phosphate => D-ribose 5-phosphate + H2O
RHEA:52590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => choloyl-CoA + NAD(+)
REACT:R-HSA-164519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)
RHEA:68443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin + O2 <=> (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal
REACT:R-SSC-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Sus scrofa)
RHEA:16325	skos:prefLabel	"glucuronate-1-phosphate uridylyltransferase"
RHEA:16325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phospho-alpha-D-glucuronate + H(+) + UTP = diphosphate + UDP-alpha-D-glucuronate
RHEA:16325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronate-1-phosphate uridylyltransferase"
RHEA:43533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 3',5'-bisphosphate + H2O => a ribonucleoside 5'-phosphate + phosphate
REACT:R-HSA-6801687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Homo sapiens)
REACT:R-CEL-5683888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMCD1 binds GATA6, sequestering it (Caenorhabditis elegans)
REACT:R-BTA-9706293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CBL (Bos taurus)
REACT:R-RNO-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Rattus norvegicus)
REACT:R-SSC-204824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Ang4 (Sus scrofa)
RHEA:35150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)
REACT:R-DRE-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Danio rerio)
REACT:R-HSA-9663736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRNA9:CHRNA10 binds acetylcholine (Homo sapiens)
REACT:R-RNO-4086083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of ING2 with SUMO1 (Rattus norvegicus)
REACT:R-SSC-8964634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Sus scrofa)
REACT:R-HSA-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Homo sapiens)
REACT:R-MMU-6803523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Mus musculus)
REACT:R-GGA-353475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex (Gallus gallus)
REACT:R-GGA-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Gallus gallus)
RHEA:31298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-hydroxypenta-2,4-dienoate <=> 2-oxopent-4-enoate
GO:0070097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-catenin binding
REACT:R-XTR-2024108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some HSPGs are secreted to the plasma membrane (Xenopus tropicalis)
RHEA:22766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O
RHEA:14758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone => 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate
REACT:R-HSA-9625091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3 bind ABCA6 gene promoter (Homo sapiens)
RHEA:50210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + H(+) + NADH => cortisol + NAD(+)
GO:0051434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3 domain binding
REACT:R-BTA-8866542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
RHEA:71480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin => L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)
RHEA:64854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + octyl benzoate => benzoyl-CoA + octan-1-ol
RHEA:38112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + NADP(+) => H(+) + L-glyceraldehyde + NADPH
REACT:R-BTA-909721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ISGF3 complex to nucleus (Bos taurus)
RHEA:32963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoglutaramate amidase"
RHEA:32963	skos:prefLabel	"omega-amidase"
RHEA:32963	skos:altLabel	"omega-amidase"
RHEA:32963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)
RHEA:32963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"omega-amidase"
RHEA:32963	skos:prefLabel	"2-oxoglutaramate amidase"
EC:4.2.99.-	skos:prefLabel	"Other carbon-oxygen lyases"
EC:4.2.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other carbon-oxygen lyases"
REACT:R-SCE-6807126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitinated PTEN translocates to the cytosol (Saccharomyces cerevisiae)
RHEA:50191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine
RHEA:48899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-2132122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1r within the C1complement complex (Gallus gallus)
REACT:R-RNO-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Rattus norvegicus)
REACT:R-SPO-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Schizosaccharomyces pombe)
REACT:R-HSA-8938431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 and BTN1A1 binds periplakin (PPL) (Homo sapiens)
REACT:R-DRE-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Danio rerio)
REACT:R-BTA-9009817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acitretin binds to RAR:RXR (Bos taurus)
REACT:R-HSA-6804193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates PRDM1 expression (Homo sapiens)
REACT:R-XTR-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Xenopus tropicalis)
REACT:R-MMU-5690856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Mus musculus)
REACT:R-BTA-3465429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(S) and procaspase-8 form heterodimer (Bos taurus)
REACT:R-GGA-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Gallus gallus)
RHEA:61275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminopentanoate + O2 <=> 2-oxopentanoate + H2O2 + NH4(+)
RHEA:31191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O
REACT:R-HSA-6802937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
REACT:R-MMU-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Mus musculus)
REACT:R-CFA-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Canis familiaris)
REACT:R-DME-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Drosophila melanogaster)
REACT:R-RNO-5618105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Rattus norvegicus)
REACT:R-DRE-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Danio rerio)
RHEA:60614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-octanoyl-sn-glycero-3-phosphocholine
RHEA:58284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + NADP(+) = H(+) + NADPH + thymine
GO:0050109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, naloxone
GO:0050109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	morphine 6-dehydrogenase activity
GO:0050109	skos:prefLabel	"morphine 6-dehydrogenase"
GO:0050109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"morphine 6-dehydrogenase"
GO:0050109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	naloxone reductase activity
GO:0050109	skos:altLabel	"naloxone reductase"
GO:0050109	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	morphine:NAD(P)+ 6-oxidoreductase activity
REACT:R-CFA-2424246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind lecticans (Canis familiaris)
RHEA:30349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ITP => ATP + IDP
RHEA:23719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-dodecenoyl-CoA <=> (2E)-dodecenoyl-CoA
RHEA:19015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + H(+) + phosphate => dTTP + H2O
REACT:R-RNO-173597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose is oxidised to UDP-glucuronate (Rattus norvegicus)
EC:4.4.1.6	skos:prefLabel	"S-alkylcysteine lyase"
EC:4.4.1.6	skos:altLabel	"S-alkyl-L-cysteine sulfoxide lyase"
EC:4.4.1.6	skos:altLabel	"S-alkyl-L-cysteine lyase"
EC:4.4.1.6	skos:altLabel	"S-alkyl-L-cysteine alkylthiol-lyase (deaminating)"
EC:4.4.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-alkylcysteine lyase"
EC:4.4.1.6	skos:altLabel	"S-alkyl-L-cysteinase"
REACT:R-MMU-8863858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC22B, CALR, STX4, TAP and TAPBP bind (Mus musculus)
REACT:R-HSA-1655837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) (Homo sapiens)
RHEA:64730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2
RHEA:16284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dihydrostreptomycin 6-phosphate <=> ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)
REACT:R-XTR-5333671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCAs self cleave (Xenopus tropicalis)
GO:0004074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin reductase (NAD(P)+) activity
GO:0004074	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bilirubin:NAD(P)+ oxidoreductase activity
RHEA:33776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)
REACT:R-DRE-381461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Plasmin proteolyzes IGF:IGFBP-3:ALS (Danio rerio)
REACT:R-HSA-428883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CAP to ABL (Homo sapiens)
RHEA:62221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phyllostine => neopatulin
REACT:R-BTA-3371385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α is cleaved by ADAM17 (TACE) (Bos taurus)
REACT:R-CFA-8874204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3 (Canis familiaris)
REACT:R-BTA-201595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plakophilin-1 (Bos taurus)
RHEA:48067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b (d18:1(4E)) + H2O <=> ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate
REACT:R-XTR-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)
REACT:R-XTR-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Xenopus tropicalis)
RHEA:13085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrahydrodipicolinate N-acetyltransferase"
RHEA:13085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA + L-2-acetamido-6-oxoheptanedioate
RHEA:13085	skos:altLabel	"tetrahydrodipicolinate acetylase"
RHEA:13085	skos:prefLabel	"tetrahydrodipicolinate N-acetyltransferase"
REACT:R-SSC-453104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits GRB2:GAB2 (Sus scrofa)
GO:0019780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAT10 activating enzyme activity
REACT:R-DDI-212005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2F1 dehydrogenates 3-methylindole (Dictyostelium discoideum)
REACT:R-SSC-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Sus scrofa)
RHEA:29495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-eudesmol synthase"
RHEA:29495	skos:prefLabel	"beta-eudesmol synthase"
RHEA:29495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = beta-eudesmol + diphosphate
REACT:R-HSA-6803063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial LPS, PGN (Homo sapiens)
RHEA:50426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin G1 => (8Z,11Z,14Z)-eicosatrienoate + 2 O2
RHEA:16807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + deacetylcephalosporin C + succinate => 2-oxoglutarate + deacetoxycephalosporin C + O2
RHEA:63261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH => 4-pyridoxate + NAD(+)
RHEA:67439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-MMU-8983335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Mus musculus)
REACT:R-RNO-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Rattus norvegicus)
REACT:R-DME-164423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PhosphoChREBP (Thr 666)  is exported to cytosol (Drosophila melanogaster)
RHEA:18959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:59940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+)
REACT:R-SSC-8852580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clusterin binds C5b-C7, C8, C9 (Sus scrofa)
REACT:R-SSC-1250346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Sus scrofa)
REACT:R-HSA-5655170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 monoubiquitinates POLH (Homo sapiens)
RHEA:16633	skos:prefLabel	"tRNA-guanosine(34) queuine transglycosylase"
RHEA:16633	skos:altLabel	"guanine insertion enzyme"
RHEA:16633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(34) in tRNA + queuine = guanine + queuosine(34) in tRNA
RHEA:16633	skos:altLabel	"TGT"
RHEA:16633	skos:altLabel	"tRNA transglycosylase"
RHEA:16633	skos:altLabel	"queuine(34) transfer ribonucleate ribosyltransferase"
RHEA:16633	skos:altLabel	"Q-insertase"
RHEA:16633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-guanosine(34) queuine transglycosylase"
RHEA:16633	skos:altLabel	"queuine tRNA-ribosyltransferase"
REACT:R-SSC-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Sus scrofa)
REACT:R-HSA-174657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Homo sapiens)
REACT:R-MMU-1471338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 1, 4A and 103 bind CCR6 (Mus musculus)
REACT:R-MMU-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Mus musculus)
RHEA:42260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptanoyl-CoA + malonyl-[ACP] = 3-oxononanoyl-[ACP] + CO2 + CoA
REACT:R-BTA-6799199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Bos taurus)
GO:0047600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity
GO:0047600	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trihexose diphospholipid abequosyltransferase activity
GO:0047600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abequosyltransferase activity
GO:0001876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAM binding
GO:0001876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoarabinomannan binding
REACT:R-BTA-163664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binds to gamma subunit of AMP kinase heterotrimer (Bos taurus)
RHEA:49268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]
GO:0042974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAR binding
GO:0042974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear retinoic acid receptor binding
GO:0042974	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	retinoic acid receptor binding
REACT:R-SPO-6811411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the Golgi (Schizosaccharomyces pombe)
REACT:R-SSC-8942344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 transports FOLA from extracellular region to cytosol (Sus scrofa)
RHEA:47897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH
RHEA:63275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-DME-742354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Drosophila melanogaster)
REACT:R-HSA-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
REACT:R-XTR-6806610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filament formation (Xenopus tropicalis)
REACT:R-HSA-8848663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADIPOQ trimer binds ADIPOR dimers (Homo sapiens)
GO:0051120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hepoxilin A3 synthase activity
REACT:R-BTA-173542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 ubiquitinates SMAD2 (Bos taurus)
RHEA:53593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycerol 3-phosphate + H2O => 1-tetradecanoyl-sn-glycerol + phosphate
RHEA:51995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-508163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Xenopus tropicalis)
RHEA:24811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + H2O => (2R)-2,3-dihydroxy-3-methylbutanoate
REACT:R-CEL-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Caenorhabditis elegans)
RHEA:44186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate
GO:0047891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity
GO:0047891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-apigenin beta-glucosyltransferase activity
GO:0047891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavone 7-O-beta-glucosyltransferase activity
GO:0047891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-luteolin beta-D-glucosyltransferase activity
GO:0047891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavone 7-O-b-glucosyltransferase activity
GO:0047891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-luteolin beta-D-glucosyltransferase activity
GO:0047891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity
GO:0047891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-apigenin beta-glucosyltransferase activity
GO:0047891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity
GO:0047891	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-luteolin glucosyltransferase activity
REACT:R-MMU-74885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCYs converts GTP to cGMP (Mus musculus)
REACT:R-BTA-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Bos taurus)
RHEA:30722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + propanoyl-CoA <=> 2-methyl-3-oxobutanoyl-CoA + CoA
RHEA:64084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) = 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2
RHEA:71591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + malonate(in) = 2-oxoglutarate(in) + malonate(out)
REACT:R-DRE-5696365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Danio rerio)
REACT:R-DRE-8964614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Danio rerio)
RHEA:71198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + Zn(2+)(out) <=> H(+)(in) + Zn(2+)(in)
REACT:R-CEL-183084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)
RHEA:60356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octanoylanthranilate = anthranilate + H(+) + octanoate
REACT:R-RNO-9033236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Rattus norvegicus)
GO:0016851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoporphyrin IX Mg-chelatase activity
GO:0016851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	magnesium chelatase activity
GO:0016851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoporphyrin IX magnesium-chelatase activity
GO:0016851	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	Mg-chelatase activity
GO:0016851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	magnesium-chelatase activity
GO:0016851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mg-protoporphyrin IX magnesio-lyase activity
GO:0016851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mg-protoporphyrin IX magnesium-lyase activity
GO:0016851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mg-protoporphyrin IX chelatase activity
GO:0016851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	magnesium-protoporphyrin chelatase activity
GO:0016851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	magnesium-protoporphyrin IX chelatase activity
RHEA:70382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-3-oxosphinganine
REACT:R-GGA-68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated geminin is degraded by the proteasome (Gallus gallus)
REACT:R-DME-9009541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds to TFF1 gene promoter (Drosophila melanogaster)
REACT:R-DME-5672950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Activator" RAF:YWHAB dimer binds RAS:GTP (Drosophila melanogaster)
REACT:R-GGA-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Gallus gallus)
RHEA:28353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-beta-L-arabinofuranose <=> UDP-beta-L-arabinopyranose
RHEA:71115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hispidin + NADH + O2 = 3-hydroxyhispidin + H2O + NAD(+)
REACT:R-BTA-5357477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 phosphorylates VE-cadherin (Bos taurus)
REACT:R-RNO-418856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 (Rattus norvegicus)
REACT:R-SSC-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)
RHEA:71400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxusin => 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0030548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine receptor regulator activity
REACT:R-SSC-9012000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Sus scrofa)
REACT:R-BTA-1250348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by ERBB4 homodimers (Bos taurus)
REACT:R-SSC-74715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of insulin receptor (Sus scrofa)
REACT:R-CFA-9733969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts dissociate from FABP6 (Canis familiaris)
REACT:R-HSA-2559464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR6/2 ligand associates with CD14 and CD36 within lipid rafts (Homo sapiens)
RHEA:37681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA
REACT:R-HSA-392748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds to AP-2 Clathrin complex (Homo sapiens)
RHEA:18810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + oxomalonate => aminomalonate + pyruvate
REACT:R-RNO-188191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1-mediated degradation of Skp2 (Rattus norvegicus)
REACT:R-DRE-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Danio rerio)
RHEA:17507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ethanolamine => H2O + N-(long-chain fatty acyl)ethanolamine
REACT:R-XTR-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Xenopus tropicalis)
RHEA:33681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2
RHEA:35288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + chloramphenicol(in) + H2O => ADP + chloramphenicol(out) + H(+) + phosphate
REACT:R-CFA-909729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JAK kinases (Canis familiaris)
RHEA:14391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine
RHEA:29586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(in) + H(+)(out) <=> guanosine(out) + H(+)(in)
GO:0015325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA:CoA antiporter activity
RHEA:22407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galacturonate + NAD(+) <=> D-galactaro-1,5-lactone + H(+) + NADH
RHEA:44005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl fatty acid + ATP + CoA => a 3-methyl fatty acyl-CoA + AMP + diphosphate
REACT:R-SSC-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Sus scrofa)
REACT:R-MMU-170153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)
GO:1904713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin destruction complex binding
GO:1904713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin degradation complex binding
GO:1904713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDC binding
GO:1904713	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	23S APC complex binding
GO:1904713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Axin-APC-beta-catenin-GSK3B complex binding
GO:1904713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC-Axin-1-beta-catenin complex binding
RHEA:71370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> epiandrosterone 3-sulfate(in) + 2 Na(+)(in)
RHEA:16031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + urea => 3-guanidinopropanoate + H2O
RHEA:25516	skos:altLabel	"TAT"
RHEA:25516	skos:prefLabel	"tropine acyltransferase"
RHEA:25516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tropine acyltransferase"
RHEA:25516	skos:altLabel	"tropine tigloyltransferase"
RHEA:25516	skos:altLabel	"tropine acetyltransferase"
RHEA:25516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + tropine = CoA + H(+) + O-acyltropine
REACT:R-CEL-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Caenorhabditis elegans)
REACT:R-DDI-893596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Dictyostelium discoideum)
RHEA:26246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate => diphosphate + fusicocca-2,10(14)-diene
REACT:R-XTR-3928604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate VAV2,3 (Xenopus tropicalis)
REACT:R-DRE-425861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Protein Kinase C novel isoforms (Danio rerio)
REACT:R-CEL-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Caenorhabditis elegans)
RHEA:46921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) => CO2 + styrene
RHEA:36167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate
RHEA:36167	skos:prefLabel	"5'-deoxynucleotidase"
RHEA:36167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5'-deoxynucleotidase"
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide ligase (NAD+) activity
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-joining enzyme
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide synthetase activity
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic repair enzyme
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polydeoxyribonucleotide synthase (NAD)
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polydeoxyribonucleotide synthase (NAD+) activity
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide synthetase (nicotinamide adenine dinucleotide)
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polydeoxyribonucleotide synthase (NAD(+)) activity
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleic joinase
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic-joining enzyme
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide ligase (NAD(+)) activity
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide ligase (nicotinamide adenine dinucleotide)
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA ligase (NAD)
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polynucleotide ligase
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleic acid joinase
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleic acid ligase
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA joinase activity
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase (NAD+) activity
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA repair enzyme activity
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleic ligase
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxyribonucleate ligase
GO:0003911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polynucleotide ligase (NAD)
REACT:R-SCE-2993802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates PC:Mn2+ (Saccharomyces cerevisiae)
GO:0047799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopentanone monooxygenase activity
GO:0047799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclopentanone 1,2-monooxygenase activity
GO:0047799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclopentanone oxygenase activity
GO:0047799	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)
GO:0005213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of egg chorion
GO:0005213	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	structural constituent of chorion
GO:0005213	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	structural protein of chorion
REACT:R-MMU-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Mus musculus)
REACT:R-RNO-9012349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)
REACT:R-SSC-6799495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYCTK phosphorylates DGA to 3PDGA (Sus scrofa)
REACT:R-DME-9709098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR dimer reduces FOLA to DHF (Drosophila melanogaster)
RHEA:57614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+) => 20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH
REACT:R-PFA-70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)
REACT:R-CFA-8952620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
REACT:R-MMU-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Mus musculus)
RHEA:27881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-UMP + H2O <=> 3'-UMP + H(+)
RHEA:42807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + A <=> 7,8-dihydromethanopterin + AH2
RHEA:30292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate
RHEA:71530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine(out) <=> thymine(in)
RHEA:14783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-CoA + AMP + diphosphate => ATP + CoA + heptanedioate
REACT:R-HSA-69299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDT1 binds geminin (Homo sapiens)
GO:0102983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylogalacturonan beta-1,3-xylosyltransferase activity
REACT:R-HSA-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Homo sapiens)
RHEA:55101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxypentanoyl-[ACP] + NADP(+)
REACT:R-SSC-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Sus scrofa)
REACT:R-HSA-389976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E (Homo sapiens)
RHEA:48164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxypheophorbide a + H2O = H(+) + red chlorophyll catabolite
REACT:R-DME-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Drosophila melanogaster)
RHEA:33363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase"
RHEA:33363	skos:altLabel	"D-mannitol PTS permease"
RHEA:33363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]
RHEA:33363	skos:prefLabel	"protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase"
RHEA:59566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N',N'',N'''-tetraacetylchitotetraonate => H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone
GO:0090704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate-O-glucosyltransferase activity
REACT:R-HSA-4793925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S303,307-HSF1 binds YWHAE (14-3-3) (Homo sapiens)
REACT:R-XTR-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)
RHEA:61028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	itaconate + L-cysteinyl-[protein] = S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]
RHEA:30719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + propanoyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA
REACT:R-DRE-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Danio rerio)
REACT:R-RNO-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Rattus norvegicus)
REACT:R-XTR-5652005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Xenopus tropicalis)
RHEA:54460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate
REACT:R-CFA-211207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fragments of DFF45 dissociate from  DFF40 (Canis familiaris)
REACT:R-CEL-392748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds to AP-2 Clathrin complex (Caenorhabditis elegans)
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-keto-delta4-steroid-5alpha-reductase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta4-3-keto steroid 5alpha-reductase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta4-5alpha-dehydrogenase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	5alpha-reductase
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta4-3-ketosteroid5alpha-oxidoreductase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-5alpha-steroid 4-dehydrogenase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-oxosteroid delta4-dehydrogenase
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid 5alpha-reductase
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid 5 alpha reductase
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	testosterone 5alpha-reductase
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxo-5alpha-steroid delta4-dehydrogenase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid 5-alpha-reductase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta4-3-oxo steroid reductase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid delta4-5alpha-reductase activity
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	delta4-3-oxosteroid-5alpha-reductase
GO:0003865	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-ene-3-ketosteroid-5alpha-oxidoreductase activity
RHEA:27515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphinganine 1-phosphate => phosphate + sphinganine
REACT:R-BTA-977071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Bos taurus)
GO:0015446	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	arsenite ABC transporter
GO:0015446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled arsenite transmembrane transporter activity
GO:0015446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenical pump-driving ATPase activity
GO:0015446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenical resistance efflux pump
GO:0015446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenite-transporting ATPase activity
GO:0015446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenite-transmembrane transporting ATPase activity
GO:0015446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenical resistance ATPase activity
GO:0015446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arsenite-translocating ATPase activity
GO:0015446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite transporting ATPase activity
REACT:R-HSA-8868783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248 (Homo sapiens)
REACT:R-BTA-199404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40L binds CD40 (Bos taurus)
REACT:R-CFA-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Canis familiaris)
RHEA:12642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + NAD(+) => 3-phosphooxypyruvate + H(+) + NADH
REACT:R-PFA-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Plasmodium falciparum)
RHEA:10034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal-L-glutamate + NH4(+) => [protein]-C-terminal-L-glutamine + H2O
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ras guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rap guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ran guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GNRP
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoGEF
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEF
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ARF guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rac guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cAMP-dependent guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanyl-nucleotide releasing factor
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Ral guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Sar guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanyl-nucleotide release factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDS
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-dissociation stimulator activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rho guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Rab guanyl-nucleotide exchange factor activity
GO:0005085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rho guanine nucleotide exchange factor
RHEA:52292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-9750946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
RHEA:66158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-butanoyltyramine => butanoyl-CoA + tyramine
RHEA:26413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-D-glucosamine 6-phosphate
RHEA:30286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-trans-permethrin + H2O <=> (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)
REACT:R-HSA-3240787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1/2/3 stimulates SUZ12 transcription (Homo sapiens)
GO:0034834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-mercaptobenzothiazole dioxygenase activity
REACT:R-BTA-8942302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP13 cleaves OPTC (Bos taurus)
REACT:R-SSC-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Sus scrofa)
RHEA:70400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-3-oxosphinganine
REACT:R-HSA-1433410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS1 as a regulator of KIT signaling (Homo sapiens)
RHEA:49429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + phosphonoformate => CMP-5'-phosphonoformate + diphosphate
RHEA:31058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate + H2O <=> estrone + H(+) + sulfate
RHEA:42629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(747) in 23S rRNA => 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:69337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-alk-1-en-1-SO-peroxol => (Z)-alkanethial oxide
RHEA:41535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine
REACT:R-RNO-8854628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLIP dimer ubiquitinates VLDLR on Lys-839 (Rattus norvegicus)
GO:0001097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH-class transcription factor binding
GO:0001097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH-class transcription factor complex binding
REACT:R-XTR-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Xenopus tropicalis)
RHEA:45305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine
REACT:R-GGA-372693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
RHEA:60294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine
RHEA:40368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)
REACT:R-HSA-351936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of claspin (Homo sapiens)
RHEA:24839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate
RHEA:54019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
RHEA:18708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP
REACT:R-HSA-388828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PD-1 binds B7DC and B7H1 (Homo sapiens)
RHEA:32254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH
REACT:R-MMU-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Mus musculus)
RHEA:40902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
REACT:R-SSC-5667008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds RHPN1 or RHPN2 (Sus scrofa)
RHEA:29143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + 2 H(+)(in) + nitrate = a ubiquinone + 2 H(+)(out) + H2O + nitrite
REACT:R-HSA-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Homo sapiens)
RHEA:44950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O
RHEA:36688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-hexadecanoylsphing-4-enine
RHEA:22733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + H(+) => 4-methylphenol + CO2
RHEA:33215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 3 diphosphate
GO:0050334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiaminase activity
GO:0050334	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thiaminase II activity
GO:0050997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quaternary ammonium group binding
GO:0050997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quaternary amine binding
GO:0070411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-SMAD binding
REACT:R-HSA-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Homo sapiens)
REACT:R-SSC-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Sus scrofa)
REACT:R-BTA-174786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Bos taurus)
RHEA:60116	skos:prefLabel	"methylphosphonate hydroxylase"
RHEA:60116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylphosphonate hydroxylase"
RHEA:60116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + methylphosphonate + O2 = CO2 + hydroxymethylphosphonate + succinate
RHEA:32508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-isopropenyl-7-methyloxepan-2-one + H2O => 6-hydroxy-3-isopropenylheptanoate + H(+)
REACT:R-HSA-9609310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β-blockers bind ADRB1,2,3 (Homo sapiens)
RHEA:61642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + CO2 => H(+) + isophthalyl-CoA
REACT:R-DRE-209921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoiodinated tyrosine can be deiodinated (Danio rerio)
REACT:R-MMU-448629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33 binds IL1RL1 (Mus musculus)
REACT:R-SSC-140664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Sus scrofa)
REACT:R-SSC-372505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylcholine synaptic vesicle docking and priming (Sus scrofa)
REACT:R-CFA-212356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL-NICD coactivator complex (Canis familiaris)
GO:0098919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of postsynaptic density
REACT:R-DRE-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Danio rerio)
REACT:R-GGA-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Gallus gallus)
REACT:R-HSA-5684043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)
RHEA:59901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 => CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate
RHEA:43965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-BTA-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Bos taurus)
REACT:R-HSA-1791177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of KLHDC3 (Homo sapiens)
REACT:R-MMU-909725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IRF9 with p-STAT2:p-STAT1 (Mus musculus)
REACT:R-SPO-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Schizosaccharomyces pombe)
REACT:R-CFA-982765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone forms dimers and oligomers (Canis familiaris)
REACT:R-HSA-9632033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHSY1 transfers GalNAc to chondroitin (Homo sapiens)
GO:0043854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MscS
GO:0043854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic nucleotide gated mechanosensitive ion channel activity
GO:0043854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic nucleotide-gated mechanosensitive ion channel activity
GO:0043854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic nucleotide regulated mechanosensitive ion channel
GO:0043854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic nucleotide-regulated mechanosensitive ion channel
GO:0043854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conductance mechanosensitive ion channel
GO:0043854	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic nucleotide-regulated small mechanosensitive ion channel
RHEA:64377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2
REACT:R-HSA-3858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL recruits RAC (Homo sapiens)
RHEA:16579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate => ADP + ATP + H(+)
RHEA:44141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate => acetyl-CoA + CO2 + reduced [flavodoxin]
RHEA:51831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)
REACT:R-DDI-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Dictyostelium discoideum)
REACT:R-DRE-170161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Danio rerio)
RHEA:66533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]
REACT:R-BTA-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Bos taurus)
REACT:R-RNO-202709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 dimerises (Rattus norvegicus)
RHEA:62920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol = 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal
REACT:R-BTA-8852552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1R autophosphorylates (Bos taurus)
RHEA:63606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Pyr1]apelin-12 + L-phenylalanine => [Pyr1]apelin-13 + H2O
REACT:R-CEL-201457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP2 binds to the receptor complex (Caenorhabditis elegans)
RHEA:30279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:30279	skos:prefLabel	"hydrogenase (NAD(+), ferredoxin)"
RHEA:30279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrogenase (NAD(+), ferredoxin)"
RHEA:30279	skos:altLabel	"bifurcating [FeFe] hydrogenase"
RHEA:18319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid => an L-alpha-amino acid
RHEA:66461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O => 14betaH-scalarane-17alpha-19-diol
GO:0035302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysteroid 25-hydroxylase activity
REACT:R-CEL-8955817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2 oxidises HPRO to 1PYR-5COOH (Caenorhabditis elegans)
REACT:R-DDI-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Dictyostelium discoideum)
REACT:R-DRE-9014293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GDIs block activation of RAC2 (Danio rerio)
RHEA:63659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
RHEA:66195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + bilirubin-bisglucuronoside(in) + H2O <=> ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate
REACT:R-DRE-158795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Danio rerio)
REACT:R-CFA-1638821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
REACT:R-HSA-205112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)
REACT:R-DRE-8985988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Danio rerio)
RHEA:30022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + lipid A-core
REACT:R-BTA-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Bos taurus)
REACT:R-XTR-9604480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFkB complex translocates from the cytosol to the nucleus (Xenopus tropicalis)
RHEA:58756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)
REACT:R-HSA-400500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)
REACT:R-DME-433104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACT co-transports trivalent citrate and a sodium ion (Drosophila melanogaster)
RHEA:64610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + uridylyl-L-threonyl-[protein] => L-threonyl-[protein] + UTP
RHEA:56380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase"
RHEA:56380	skos:prefLabel	"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase"
RHEA:56380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O
REACT:R-SSC-909722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-STAT2:p-STAT1 dimer (Sus scrofa)
REACT:R-MMU-936941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Mus musculus)
RHEA:38858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-DME-443439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-Src binds Raf1 (Drosophila melanogaster)
REACT:R-BTA-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)
REACT:R-DRE-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Danio rerio)
RHEA:59304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + firefly L-luciferin = adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)
RHEA:20750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + deacetoxycephalosporin C + H2O + succinate => 2-oxoglutarate + O2 + penicillin N
RHEA:22471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + 3 H2O <=> 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate
RHEA:30856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammarenediol-II => (S)-2,3-epoxysqualene + H2O
REACT:R-CFA-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Canis familiaris)
REACT:R-DME-4719448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO3 (Drosophila melanogaster)
REACT:R-DRE-418576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the P2Y purinoceptor 1:Gq complex (Danio rerio)
REACT:R-BTA-9668902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18-RFC(7s) complex (Bos taurus)
REACT:R-RNO-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Rattus norvegicus)
RHEA:42808	skos:prefLabel	"sulfite reductase (coenzyme F420)"
RHEA:42808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) = 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite
RHEA:42808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfite reductase (coenzyme F420)"
RHEA:42808	skos:altLabel	"coenzyme F420-dependent sulfite reductase"
REACT:R-HSA-1602368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Homo sapiens)
RHEA:34180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mycophenolic acid O-acyl-beta-D-glucuronide => D-glucuronate + H(+) + mycophenolate
GO:0044692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exoribonuclease activator activity
REACT:R-SSC-5654591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)
REACT:R-SSC-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)
RHEA:52612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-XTR-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Xenopus tropicalis)
GO:0090490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
REACT:R-SSC-416562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGAP binds Plexin-B1 (Sus scrofa)
RHEA:39627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA = (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O
GO:0017153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:dicarboxylate symporter activity
GO:0017153	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium:dicarboxylate cotransporter activity
REACT:R-DRE-5684875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR:ATRIP to RPA at resected DNA DSBs (Danio rerio)
REACT:R-DRE-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Danio rerio)
REACT:R-GGA-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Gallus gallus)
REACT:R-GGA-5635859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU dissociates (Gallus gallus)
RHEA:54042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,7E)-dolathalia-3,7,11-triene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-DDI-2090038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses heparan chain(2) (Dictyostelium discoideum)
REACT:R-MMU-83723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Mus musculus)
REACT:R-HSA-8850818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK9 binds KLK5 (Homo sapiens)
RHEA:33708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonine => ADP + H(+) + O-phospho-L-threonine
REACT:R-BTA-5665809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Bos taurus)
RHEA:59164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]
RHEA:59164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain fatty acid adenylase/transferase FadD23"
RHEA:59164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate = AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]
RHEA:59164	skos:altLabel	"long-chain fatty acid adenylyltransferase FadD23"
RHEA:59164	skos:prefLabel	"long-chain fatty acid adenylase/transferase FadD23"
REACT:R-SSC-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Sus scrofa)
RHEA:24620	skos:prefLabel	"octanol dehydrogenase"
RHEA:24620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"octanol dehydrogenase"
RHEA:24620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + octan-1-ol = H(+) + NADH + octanal
REACT:R-XTR-163096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Telomerase RNP to the Telomeric Chromosome End (Xenopus tropicalis)
GO:0008482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfite:oxygen oxidoreductase activity
GO:0008482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite oxidase activity
GO:0008482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphite oxidase activity
REACT:R-SSC-917933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Sus scrofa)
REACT:R-DME-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Drosophila melanogaster)
REACT:R-CFA-9707659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes:LY96 activates TLR4 (Canis familiaris)
GO:0001605	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	G10D receptor
GO:0001605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenomedullin receptor activity
RHEA:47523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isolithocholate + NADP(+)
RHEA:65386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O
RHEA:52188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O
RHEA:67906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA => glutaryl-CoA + H(+) + malonyl-[ACP]
RHEA:31596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylureidoacrylate + H2O => (Z)-2-methylaminoacrylate + carbamate + H(+)
REACT:R-DRE-4568914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of BLM with SUMO2,3 (Danio rerio)
REACT:R-DRE-6809707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTMR2 (Danio rerio)
REACT:R-XTR-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Xenopus tropicalis)
REACT:R-HSA-1592251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of mTERF (Homo sapiens)
REACT:R-CFA-8867240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPCAM binds itself to form homotypic cell adhesion (Canis familiaris)
REACT:R-GGA-400509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Gallus gallus)
RHEA:24095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 sulochrin <=> 2 (2S)-bisdechlorogeodin + 2 H2O
RHEA:51456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-isoleucine = (9Z)-octadecenoate + L-isoleucine
REACT:R-HSA-8952442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 gene expression is stimulated by RUNX3 (Homo sapiens)
RHEA:38477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine => L-histidine + S-adenosyl-L-methionine
REACT:R-CFA-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Canis familiaris)
REACT:R-CFA-204850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Dok-2 (Canis familiaris)
REACT:R-GGA-5654399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS2 (Gallus gallus)
REACT:R-SPO-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Schizosaccharomyces pombe)
REACT:R-SSC-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Sus scrofa)
REACT:R-RNO-2161613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Rattus norvegicus)
REACT:R-RNO-174963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1 acetylation (Rattus norvegicus)
GO:0030411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	scytalone 7,8-hydro-lyase activity
GO:0030411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scytalone dehydratase activity
GO:0030411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)
REACT:R-SSC-72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of mRNA at the 3'-end (Sus scrofa)
RHEA:28296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:53803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholoyl-CoA + ursodeoxycholate <=> lithocholate + ursodeoxycholoyl-CoA
REACT:R-XTR-9754916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer phosphorylates RBV (Xenopus tropicalis)
REACT:R-DDI-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
RHEA:66921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate => (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate
REACT:R-BTA-189425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO3 to COPRO3 (Bos taurus)
GO:0015100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vanadium ion transmembrane transporter activity
RHEA:67512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
GO:0019147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aminopropanol dehydrogenase activity
GO:0019147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-aminopropan-2-ol-dehydrogenase activity
GO:0019147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity
GO:0019147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity
GO:0019147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-aminopropanol dehydrogenase activity
GO:0019147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-aminopropan-2-ol-NAD+ dehydrogenase activity
GO:0019147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity
GO:0019147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity
GO:0019152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetyl reductase activity
GO:0019152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin dehydrogenase activity
RHEA:50867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
REACT:R-DDI-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Dictyostelium discoideum)
RHEA:65283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate <=> 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)
RHEA:57359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + chloride + H(+) + hapalindole U + O2 <=> CO2 + H2O + hapalindole G + succinate
REACT:R-MMU-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Mus musculus)
REACT:R-SSC-8865454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX3 (Sus scrofa)
REACT:R-DRE-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Danio rerio)
RHEA:22355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-lysine <=> cadaverine + CO2
RHEA:56650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-24-oyl-CoA + NAD(+)
REACT:R-CFA-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Canis familiaris)
RHEA:13030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamine + O2 => H(+) + H2O2 + N-acetyl-D-glucosaminate
RHEA:35771	skos:prefLabel	"3-amino-5-hydroxybenzoate synthase"
RHEA:35771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-5-amino-3-dehydroshikimate = 3-amino-5-hydroxybenzoate + H(+) + H2O
RHEA:35771	skos:altLabel	"AHBA synthase"
RHEA:35771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-amino-5-hydroxybenzoate synthase"
RHEA:48717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 13-oxo-(9Z,11E)-octadecadienoate + H2O
RHEA:40834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine
REACT:R-HSA-8955706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin (Homo sapiens)
RHEA:20205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylazoxymethanol + UDP-alpha-D-glucose = cycasin + H(+) + UDP
RHEA:20205	skos:prefLabel	"methyl-ONN-azoxymethanol beta-D-glucosyltransferase"
RHEA:20205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methyl-ONN-azoxymethanol beta-D-glucosyltransferase"
RHEA:20205	skos:altLabel	"cycasin synthase"
RHEA:28110	skos:altLabel	"chlorinase"
RHEA:28110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosyl-chloride synthase"
RHEA:28110	skos:altLabel	"5'-chloro-5'-deoxyadenosine synthase"
RHEA:28110	skos:prefLabel	"adenosyl-chloride synthase"
RHEA:28110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + S-adenosyl-L-methionine = 5'-chloro-5'-deoxyadenosine + L-methionine
REACT:R-BTA-4341048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RXRA with SUMO1 (Bos taurus)
REACT:R-RNO-1604360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP14 (Rattus norvegicus)
GO:0030561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA 2'-O-ribose methylation guide activity
REACT:R-CFA-193060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
RHEA:54449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-alpha-aminoacyl-tRNA + H2O => a tRNA + an N-acyl-L-amino acid + H(+)
RHEA:63896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspulvinone E + hnu = isoaspulvinone E
GO:0102370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lupeol 28-monooxygenase activity
REACT:R-HSA-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Homo sapiens)
RHEA:29551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucose = alpha-D-galactose 1-phosphate + 2 H(+) + UMP
RHEA:18817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + malonate = acetate + malonyl-CoA
RHEA:18817	skos:prefLabel	"malonate CoA-transferase"
RHEA:18817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malonate CoA-transferase"
GO:0019763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	immunoglobulin receptor activity
GO:0019763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FC receptor activity
REACT:R-BTA-879907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate the receptor (Bos taurus)
REACT:R-HSA-9023592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds HTT (Homo sapiens)
REACT:R-MMU-8938853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 binds RUNX1 (Mus musculus)
REACT:R-DRE-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Danio rerio)
RHEA:54671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-alpha-onocerin <=> alpha-onocerin
REACT:R-RNO-165692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of 4E-BP1 by activated mTORC1 (Rattus norvegicus)
GO:0018807	skos:altLabel	"6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase"
GO:0018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity
GO:0018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase"
GO:0018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)
GO:0018807	skos:prefLabel	"6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase"
RHEA:30470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphate
REACT:R-CFA-388809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTLA-4 binds B7-1/B7-2 (Canis familiaris)
GO:0001147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription termination site sequence-specific DNA binding
GO:0001147	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial RNA polymerase termination site sequence-specific DNA binding
GO:0001147	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding
GO:0001147	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription termination site DNA binding
GO:0001147	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase termination site sequence-specific DNA binding
GO:0001147	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity
REACT:R-CEL-77312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Caenorhabditis elegans)
RHEA:40793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + hexacosanoate => H2O + hexacosanoyl-CoA
REACT:R-BTA-1297354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acrosin Cleavage (Bos taurus)
REACT:R-SPO-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Schizosaccharomyces pombe)
RHEA:39442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA <=> (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O
RHEA:17526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biuret + H2O => NH4(+) + urea-1-carboxylate
RHEA:62224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + neopatulin = (E)-ascladiol + NADP(+)
RHEA:19559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O => AH2 + O2 + pregna-4,9(11)-diene-3,20-dione
REACT:R-CFA-917807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Canis familiaris)
RHEA:60187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucose(out) + H2O <=> ADP + D-glucose(in) + H(+) + phosphate
RHEA:37578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
GO:0044584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellodextrin binding
REACT:R-DME-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Drosophila melanogaster)
REACT:R-BTA-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
RHEA:39363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA = (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O
RHEA:54964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-[ACP] + phosphate = hexadecanoyl phosphate + holo-[ACP]
RHEA:63693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol glucuronate acceptor + UDP-alpha-D-glucuronate => a beta-D-glucuronoside + H(+) + UDP
REACT:R-SSC-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Sus scrofa)
RHEA:56167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Canis familiaris)
REACT:R-CFA-9700171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates PLCG1 (Canis familiaris)
REACT:R-MMU-5692775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Mus musculus)
GO:0031710	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neuromedin B receptor ligand
GO:0031710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuromedin B receptor binding
REACT:R-DRE-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Danio rerio)
REACT:R-GGA-195300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Gallus gallus)
REACT:R-MMU-112342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of MAP2K1 by CDK1 (Mus musculus)
GO:0140360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-GMP-AMP transmembrane transporter activity
RHEA:29891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-histidine(out) = ADP + H(+) + L-histidine(in) + phosphate
GO:0097690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron ion transmembrane transporter inhibitor activity
GO:0097690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron channel inhibitor activity
RHEA:40676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine => 2-aminobut-2-enoate + H2O
RHEA:71630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) + succinate(out) <=> phosphate(out) + succinate(in)
REACT:R-HSA-3928654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin internalises EPH:EFN complexes (Homo sapiens)
RHEA:70928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate(in) + H(+)(in) => (R)-glycerate(out) + H(+)(out)
RHEA:21859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexa-1,5-diene-1-carbonyl-CoA + H2O <=> 6-hydroxycyclohex-1-ene-1-carbonyl-CoA
RHEA:63087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + ilicicolin B + O2 <=> FAD + H(+) + 2 H2O + ilicicolin A
RHEA:54492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine
RHEA:10165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate => H2O + phosphoenolpyruvate
RHEA:25185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dichloroethane + H2O = 2-chloroethanol + chloride + H(+)
RHEA:37341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-amino-2-methylpropanoate + CO2 + NH4(+) => 3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O
REACT:R-GGA-437984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)
RHEA:20677	skos:prefLabel	"alizarin 2-beta-glucosyltransferase"
RHEA:20677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alizarin + UDP-alpha-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP
RHEA:20677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alizarin 2-beta-glucosyltransferase"
GO:0018838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mandelate racemase activity
REACT:R-MMU-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Mus musculus)
REACT:R-DDI-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Dictyostelium discoideum)
REACT:R-HSA-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Homo sapiens)
GO:0140631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde dehydrogenase (NAD+) inhibitor activity
REACT:R-RNO-2022056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPG and CSPG translocate to the lysosome for degradation (Rattus norvegicus)
REACT:R-DRE-443986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor ACKR2 binds most inflammatory CC chemokines (Danio rerio)
RHEA:34563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-alpha-D-abequose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH
RHEA:34563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"CDP-abequose synthase"
RHEA:34563	skos:prefLabel	"CDP-abequose synthase"
REACT:R-SSC-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Sus scrofa)
REACT:R-DDI-200661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Dictyostelium discoideum)
REACT:R-HSA-8871265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD4 (Homo sapiens)
REACT:R-CFA-158795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Canis familiaris)
RHEA:24147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MKK2
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MKK4
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKK activity
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK27
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK activator kinase activity
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAPKK1
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MKK
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MKK6
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAP2K
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein phosphotransferase (MAPKKK-activated) activity
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAPKK
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAP kinase or ERK kinase activity
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MEK2
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MAP kinase kinase 4 activity
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitogen-activated protein kinase kinase activity
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MAP kinase kinase 7 activity
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP kinase kinase activity
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	MEK activity
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MKK7
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MEK1
GO:0004708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK activator activity
REACT:R-HSA-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)
REACT:R-XTR-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Xenopus tropicalis)
REACT:R-RNO-8987096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Rattus norvegicus)
RHEA:67310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one
REACT:R-MMU-8944255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VII (Mus musculus)
REACT:R-SSC-6814674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Sus scrofa)
REACT:R-BTA-9605600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Bos taurus)
RHEA:64493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] => dehydrocitreoisocoumarin + H2O + holo-[ACP]
RHEA:44027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O
RHEA:62551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP
RHEA:38624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:69261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate
REACT:R-DME-75872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Drosophila melanogaster)
REACT:R-MMU-426522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nonendonucleolytic RISC binds exactly matching target RNAs (Mus musculus)
RHEA:70062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Danio rerio)
REACT:R-CEL-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonucleic acid methylase activity
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonucleic acid methyltransferase activity
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA methyltransferase activity
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NoRC:HDAC:DNMT methylates cytosine of the rRNA genes (Homo sapiens)
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA methylase
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA transmethylase activity
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonucleate methyltransferase activity
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-methyltransferase activity
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Type II DNA methylase
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic acid modification methylase activity
GO:0009008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonucleate methylase activity
RHEA:38568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate
REACT:R-MMU-193789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Mus musculus)
RHEA:10317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + thymine => 5-hydroxymethyluracil + CO2 + succinate
REACT:R-BTA-6807027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 and PTPN2 dephosphorylate MET (Bos taurus)
REACT:R-DME-6803789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Drosophila melanogaster)
RHEA:20513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arylmalonate decarboxylase"
RHEA:20513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO2
RHEA:20513	skos:altLabel	"2-aryl-2-methylmalonate carboxy-lyase"
RHEA:20513	skos:prefLabel	"arylmalonate decarboxylase"
RHEA:20513	skos:altLabel	"AMDase"
RHEA:21298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactono-1,4-lactone + H(+) + NADH => D-galactose + NAD(+)
GO:0015370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Homo sapiens)
GO:0015370	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proline/glycine/betaine:hydrogen/sodium symporter activity
GO:0015370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:sodium symporter activity
RHEA:25537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate => diphosphate + ent-sandaracopimara-8(14),15-diene
RHEA:69918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(out) + 2 Na(+)(out) <=> guanosine(in) + 2 Na(+)(in)
RHEA:71749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + L-2-aminoadipate(out) => 2-oxoglutarate(out) + L-2-aminoadipate(in)
RHEA:27339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin]
GO:0102929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lachrymatory factor synthase activity
GO:0052654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine transaminase activity
GO:0052654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine aminotransferase activity
RHEA:65712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + GDP-beta-L-galactose = beta-L-galactose 1-phosphate + GDP-alpha-D-glucose
RHEA:32012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (+)-T-muurolol + diphosphate
RHEA:14487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-epi-juneol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:11431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + O2 <=> D-glucono-1,5-lactone + H2O2
REACT:R-GGA-5692781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Gallus gallus)
GO:0008805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbon-monoxide dehydrogenase (cytochrome b-561)
GO:0008805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + CO + H2O = a quinol + CO2
GO:0008805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon monoxide oxygenase activity
GO:0008805	skos:prefLabel	"aerobic carbon monoxide dehydrogenase"
GO:0008805	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carbon monoxide oxygenase (cytochrome b-561) activity
GO:0008805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aerobic carbon monoxide dehydrogenase"
GO:0008805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbon monoxide oxidase activity
GO:0008805	skos:altLabel	"molybdoenzyme carbon monoxide dehydrogenase"
GO:0008805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbon monoxide,water:cytochrome b-561 oxidoreductase activity
GO:0008805	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome b561
GO:0008805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon-monoxide oxygenase activity
GO:0008805	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carbon monoxide:methylene blue oxidoreductase activity
REACT:R-HSA-9026005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Homo sapiens)
RHEA:68105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone
REACT:R-MMU-2201293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TLR4:LY96:LPS:CD14 (Mus musculus)
REACT:R-CFA-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Canis familiaris)
RHEA:67634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin] => a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DME-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Drosophila melanogaster)
RHEA:55945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloroethanol + 2 Fe(III)-[cytochrome c] => chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-CFA-5358340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoproteolytic cleavage of Hh precursors (Canis familiaris)
REACT:R-GGA-5577050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Gallus gallus)
REACT:R-DDI-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Dictyostelium discoideum)
REACT:R-DME-8871266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD3 (Drosophila melanogaster)
GO:0070677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (cytosine-2'-O-)-methyltransferase activity
REACT:R-DME-110221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by SMUG1 glycosylase (Drosophila melanogaster)
REACT:R-BTA-380574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine synaptic vesicle docking and priming (Bos taurus)
RHEA:50027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine
REACT:R-MMU-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Mus musculus)
REACT:R-BTA-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Bos taurus)
RHEA:51434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1S)-1-acetamidoethyl]phosphonate + CoA => (S)-1-aminoethylphosphonate + acetyl-CoA
REACT:R-DME-5694409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleotide exchange on RAB1 (Drosophila melanogaster)
REACT:R-GGA-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Gallus gallus)
REACT:R-HSA-205115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF:p75NTR complex binds to NRAGE (Homo sapiens)
REACT:R-HSA-9701549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter (Homo sapiens)
REACT:R-SSC-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Sus scrofa)
REACT:R-HSA-2424486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
REACT:R-XTR-8852306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Xenopus tropicalis)
REACT:R-HSA-2484822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore assembly (Homo sapiens)
RHEA:50295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]
GO:1905763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAXT complex binding
GO:1905763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NURS complex binding
GO:1905763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTREC complex binding
GO:1905763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mtl1-Red1 core complex binding
REACT:R-RNO-1482679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)
RHEA:36353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine
REACT:R-CEL-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Caenorhabditis elegans)
REACT:R-MMU-9647982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Mus musculus)
RHEA:22266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O => 3,5,6-trichloropyridin-2-ol + FADH2 + O2
REACT:R-XTR-5577213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:24948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methylglutarate + malonyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + malonate
RHEA:32011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-T-muurolol synthase"
RHEA:32011	skos:prefLabel	"(+)-T-muurolol synthase"
RHEA:32011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-keto-acyl thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KAT
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA acyltransferase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiolase I
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-methylacetoacetyl-CoA thiolase
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketoacyl coenzyme A thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:acetyl-CoA C-acyltransferase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-ketoadipyl-CoA thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketoacyl-CoA thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-3-ketoacyl-CoA thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ketoadipyl coenzyme A thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-coenzyme A thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketoacyl thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxoacyl-coenzyme A thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA beta-ketothiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacyl-CoA thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketoacyl CoA thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ketoacyl-coenzyme A thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA C-acyltransferase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ketothiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-ketoacyl-CoA thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain 3-oxoacyl-CoA thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ketoacyl-CoA acyltransferase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxoacyl-CoA thiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketothiolase activity
GO:0003988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ketoacyl coenzyme A thiolase activity
REACT:R-DRE-9756177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse ATVL to ATV (Danio rerio)
REACT:R-CFA-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Canis familiaris)
GO:0072551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity
RHEA:21573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methyl-1H-quinolin-4-one + O2 => CO + H(+) + N-acetylanthranilate
RHEA:47541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxolithocholate + H(+) + NADPH => NADP(+) + ursodeoxycholate
REACT:R-RNO-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Rattus norvegicus)
REACT:R-DRE-166792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C2 into C2a and C2b (Danio rerio)
REACT:R-CFA-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
RHEA:43357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z,12Z)-octadecadienoate(in) => cholesteryl (9Z,12Z)-octadecadienoate(out)
REACT:R-HSA-5362422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds to DISP2 (Homo sapiens)
REACT:R-HSA-9752951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHX2, LDB1, and EBF1 bind Olfactory Receptor gene and intergenic olfactory enhancers (Homo sapiens)
RHEA:61232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine + O2 = (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)
REACT:R-DME-390281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Drosophila melanogaster)
GO:0042625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled ion transmembrane transporter activity
GO:0042625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase coupled ion transmembrane transporter activity
GO:0042625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase activity, coupled to transmembrane movement of ions
GO:0042625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent ion transmembrane transporter activity
RHEA:36488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine
RHEA:45034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite => 4 Fe(III)-[cytochrome c] + H2O + hydroxylamine
RHEA:37149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA
REACT:R-HSA-9735789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)
REACT:R-DRE-2730858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of BTK/ITK (Danio rerio)
REACT:R-SPO-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Schizosaccharomyces pombe)
REACT:R-RNO-2059926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPHP4 protein binds LATS proteins (Rattus norvegicus)
RHEA:38230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9Z)-octadecenoate
REACT:R-GGA-5607759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIKA2 binds K63polyUb-TRAF6 oligomer (Gallus gallus)
GO:0042888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdenum ion transmembrane transporter activity
REACT:R-MMU-163825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)
RHEA:60354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO + H(+) + N-octanoylanthranilate => 2-heptyl-3-hydroxy-4(1H)-quinolone + O2
REACT:R-RNO-8987070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)
RHEA:47642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine
REACT:R-RNO-888577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GABA by GAD2 (Rattus norvegicus)
RHEA:63429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + levoglucosan => ADP + D-glucose 6-phosphate + H(+)
RHEA:43381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-phospho-L-arginyl-[protein] => L-arginyl-[protein] + phosphate
EC:5.6.1.4	skos:altLabel	"non-claret disjunctional"
EC:5.6.1.4	skos:prefLabel	"minus-end-directed kinesin ATPase"
EC:5.6.1.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"minus-end-directed kinesin ATPase"
REACT:R-BTA-2022398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Bos taurus)
RHEA:39756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-5665727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds CDC42:GTP (Caenorhabditis elegans)
REACT:R-HSA-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Homo sapiens)
RHEA:27831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neryl diphosphate => beta-phellandrene + diphosphate
RHEA:43482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:14187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + CO2 => 3-phenylpyruvate + H(+)
REACT:R-XTR-1632843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMBRA1 binds DYNLL1,DYNLL2 (Xenopus tropicalis)
RHEA:50009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylpretetramide + 2 H(+) + NADPH + O2 => 4-hydroxy-6-methylpretetramide + H2O + NADP(+)
RHEA:45203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)
REACT:R-HSA-5665999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 translocates from cytosol to the nucleus (Homo sapiens)
GO:0047498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent phospholipase A2 activity
GO:0047498	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium-dependent cytosolic phospholipase A2 activity
GO:0047498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Homo sapiens)
GO:0047498	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium-dependent secreted phospholipase A2 activity
RHEA:13337	skos:prefLabel	"uronolactonase"
RHEA:13337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uronolactonase"
RHEA:13337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucurono-6,2-lactone + H2O = D-glucuronate + H(+)
REACT:R-XTR-5684140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates RBBP8 (Xenopus tropicalis)
RHEA:47450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:47409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA
RHEA:12127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + shikimate <=> CoA + trans-4-coumaroylshikimate
REACT:R-MMU-9647632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDME (Mus musculus)
REACT:R-DRE-549304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal clearance of organic cations (Danio rerio)
REACT:R-XTR-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Xenopus tropicalis)
REACT:R-XTR-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:42694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n+2) + phosphate => [(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate
REACT:R-DRE-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Danio rerio)
GO:0016713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen
GO:0016713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
REACT:R-MMU-4755479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKB2 with SUMO1 (Mus musculus)
RHEA:62622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + an alcohol + H2O => [thioredoxin]-dithiol + a hydroperoxide
RHEA:46726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-methyltetradecanoyl-CoA => (2S)-2-methyltetradecanoyl-CoA
REACT:R-SSC-425482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1,2,3 exchanges HCO3- for Cl- (Sus scrofa)
RHEA:32260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1-phosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde
REACT:R-MMU-159431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Mus musculus)
RHEA:71695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + L-alanyl-L-aspartate(out) = 2 H(+)(in) + L-alanyl-L-aspartate(in)
REACT:R-SSC-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Sus scrofa)
REACT:R-SPO-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Schizosaccharomyces pombe)
REACT:R-CFA-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Canis familiaris)
REACT:R-XTR-5654655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PPTN11 (Xenopus tropicalis)
REACT:R-SSC-9029580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Sus scrofa)
RHEA:40482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:68412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate 5-semialdehyde + NADP(+) = 2 H(+) + L-glutamate + NADPH
RHEA:35746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + versicolorin B <=> 2 H2O + NADP(+) + versicolorin A
REACT:R-CFA-5654612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
RHEA:46875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB
REACT:R-HSA-5612510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)
RHEA:44598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + holo-[ACP] => a fatty acyl-[ACP] + H2O
GO:0102389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyprenol reductase activity
REACT:R-XTR-6787533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Xenopus tropicalis)
REACT:R-CFA-265422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaEbeta7 with Cadherin-1 (Canis familiaris)
RHEA:71610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + phosphate(out) <=> (S)-malate(out) + phosphate(in)
REACT:R-DME-428205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [Golgi] (Drosophila melanogaster)
RHEA:15706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinone + H2O + phenylacetyl-CoA => 2 a ubiquinol + phenylglyoxylyl-CoA
REACT:R-RNO-2028670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Rattus norvegicus)
REACT:R-HSA-1471354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNP1-3 bind gp120 (Homo sapiens)
REACT:R-XTR-159358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A3,4 dimers sulfate DA to DAOS (Xenopus tropicalis)
RHEA:39367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)
RHEA:62367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-N(5)-peroxide + thymine <=> (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)
REACT:R-DME-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Drosophila melanogaster)
REACT:R-HSA-168909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)
REACT:R-MMU-3000411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates PML with SUMO2 (Mus musculus)
REACT:R-PFA-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Plasmodium falciparum)
REACT:R-DME-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Drosophila melanogaster)
RHEA:59984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-acyl-L-glutamine + H2O = a carboxylate + L-glutamine
REACT:R-CFA-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Canis familiaris)
RHEA:13006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine => H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine
REACT:R-MMU-450463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Mus musculus)
REACT:R-DME-5690023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL binds 4Fe-4S (Drosophila melanogaster)
GO:0034550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylarsinate reductase activity
RHEA:49031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine-2-monooxygenase activity
GO:0050067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine monooxygenase activity
GO:0050067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine oxygenase activity
GO:0050067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine 2-monooxygenase activity
GO:0050067	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine:oxygen 2-oxidoreductase (decarboxylating)
RHEA:31726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Caenorhabditis elegans)
REACT:R-DRE-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Danio rerio)
REACT:R-XTR-6801666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates CENPJ (Xenopus tropicalis)
REACT:R-BTA-6804762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 forms homotetramers (Bos taurus)
RHEA:11297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate + H2O + NADP(+) => 2-oxoglutarate + 2 H(+) + NADPH
REACT:R-HSA-5678544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RA:IL17RE binds IL17C dimer (Homo sapiens)
REACT:R-MMU-2076508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS2ST1 sulfates IdoA at C2 in heparan sulfate (Mus musculus)
REACT:R-DRE-376851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Danio rerio)
REACT:R-RNO-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Rattus norvegicus)
RHEA:66055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + L-kynurenine <=> H2O + kynurenate + L-tryptophan
REACT:R-GGA-9609742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Gallus gallus)
REACT:R-BTA-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Bos taurus)
RHEA:21643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH
REACT:R-BTA-2090085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan chain(1) (Bos taurus)
RHEA:33662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-tetracosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)
REACT:R-DME-9012761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI binds RHOA-GDI (Drosophila melanogaster)
REACT:R-DRE-5696945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates CCP110,ARRB (Danio rerio)
GO:0072590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-aspartate-L-glutamate ligase activity
GO:0072590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Homo sapiens)
REACT:R-RNO-3249392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Rattus norvegicus)
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-sulfate sulphohydrolase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-sulphate sulphohydrolase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfatase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrocatechol sulfatase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-nitrophenyl sulfatase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-sulfate sulfohydrolase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylsulfohydrolase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methylumbelliferyl sulfatase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylsulphatase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylsulfatase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenolsulfatase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylsulfatase activity
GO:0004065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	estrogen sulfatase activity
RHEA:55982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+) => a 1,2-saturated acyl-CoA + an acyl-CoA + H2O
REACT:R-MMU-5668467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTNFR2 binds TNFA trimer:TNFR2 (Mus musculus)
REACT:R-CFA-199202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphopantetheine conjugation of the ACP domain of FAS (Canis familiaris)
RHEA:26200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + melamine <=> ammeline + NH4(+)
REACT:R-HSA-9694438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc is transferred onto 3a (Homo sapiens)
REACT:R-CEL-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
REACT:R-SPO-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Schizosaccharomyces pombe)
RHEA:23549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(966) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:54012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
REACT:R-RNO-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Rattus norvegicus)
REACT:R-SSC-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)
REACT:R-BTA-9709406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to Cytochrome c oxidase (Bos taurus)
REACT:R-GGA-5682983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates WHSC1 (Gallus gallus)
REACT:R-CFA-204947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF migrates to the nucleus (Canis familiaris)
RHEA:71002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Homo sapiens)
REACT:R-MMU-111966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 binds CALM1:4Ca2+ (Mus musculus)
RHEA:67670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine
RHEA:28244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pratensein + reduced [NADPH--hemoprotein reductase]
GO:0016434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (cytosine) methyltransferase activity
RHEA:40397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NAD(+) => 1,2-dihydro-beta-NAD + H(+) + O2
RHEA:56432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate
REACT:R-PFA-2046083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Plasmodium falciparum)
REACT:R-RNO-5693373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Rattus norvegicus)
REACT:R-CFA-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Canis familiaris)
REACT:R-XTR-6794355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 binds mGluR1a,5 (Xenopus tropicalis)
RHEA:36783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine
RHEA:36783	skos:prefLabel	"2-(3-amino-3-carboxypropyl)histidine synthase"
RHEA:36783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-(3-amino-3-carboxypropyl)histidine synthase"
RHEA:45230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-saturated (2E)-enoyl-CoA => a (3E)-enoyl-CoA
RHEA:58640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine
REACT:R-CFA-203553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS binds NOSIP (Canis familiaris)
RHEA:72088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurodeoxycholate(out) => 2 Na(+)(in) + taurodeoxycholate(in)
REACT:R-MMU-8985973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Mus musculus)
REACT:R-GGA-4551648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO1 (Gallus gallus)
RHEA:64628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + octan-1-ol = CoA + octyl acetate
REACT:R-BTA-5624949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the anterograde IFT train (Bos taurus)
REACT:R-SPO-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Schizosaccharomyces pombe)
REACT:R-SSC-1963586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC family kinases phosphorylate ERBB2 (Sus scrofa)
REACT:R-DDI-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Dictyostelium discoideum)
REACT:R-GGA-1168459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lyn activates ERK (Gallus gallus)
RHEA:70622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-5419264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Rattus norvegicus)
REACT:R-SPO-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Schizosaccharomyces pombe)
REACT:R-MMU-5649801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Mus musculus)
RHEA:43350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z-octadecenoate)(out) => cholesteryl (9Z-octadecenoate)(in)
GO:0034739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4K16 deacetylase activity
GO:0034739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone deacetylase activity (H4-K16 specific)
GO:0034739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H4-K16 deacetylase activity
REACT:R-GGA-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Gallus gallus)
RHEA:65173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z,5E)-dodecadienoyl-CoA + H2O => (3Z,5E)-dodecadienoate + CoA + H(+)
REACT:R-SSC-8876454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND3 exchanges GTP for GDP on RAB12 (Sus scrofa)
RHEA:44467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine
RHEA:50038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine => choloyl-CoA + H2O
REACT:R-DRE-5669012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA binds EDAR (Danio rerio)
REACT:R-RNO-9607304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Rattus norvegicus)
REACT:R-HSA-9701485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds JAK3 (Homo sapiens)
RHEA:72721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+) => (R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein]
RHEA:10670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys)
GO:0103030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity
REACT:R-CEL-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Caenorhabditis elegans)
REACT:R-SCE-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Saccharomyces cerevisiae)
REACT:R-HSA-110353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)
GO:0019980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-5 binding
GO:0019980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-5 binding
REACT:R-DRE-8984021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Danio rerio)
RHEA:58200	skos:prefLabel	"6-aminohexanoate aminotransferase"
RHEA:58200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-aminohexanoate aminotransferase"
RHEA:58200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 6-aminohexanoate = 6-oxohexanoate + L-glutamate
RHEA:51555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + NADP(+) <=> H(+) + L-xylo-3-hexulose + NADPH
RHEA:45808	skos:prefLabel	"galactarate dehydratase (D-threo-forming)"
RHEA:45808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactarate dehydratase (D-threo-forming)"
RHEA:45808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate = (2S,3R)-dihydroxy-5-oxohexanedioate + H2O
REACT:R-HSA-9647632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDME (Homo sapiens)
REACT:R-BTA-193727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
RHEA:35946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brevianamide F + dimethylallyl diphosphate <=> deoxybrevianamide E + diphosphate
REACT:R-CEL-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Caenorhabditis elegans)
GO:0033815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BIS
GO:0033815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:benzoyl-CoA malonyltransferase activity
GO:0033815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl synthase activity
RHEA:58935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH <=> 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)
REACT:R-SSC-5687758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP4C:PPP4R2 dephosphorylates RPA2 (Sus scrofa)
RHEA:48873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a gentamycin + GTP => a gentamycin 2''-phosphate + GDP + H(+)
REACT:R-DME-444879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin receptor 2 binds relaxin 2 and INSL3 (Drosophila melanogaster)
REACT:R-DDI-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)
RHEA:42705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hercynine + L-cysteine + O2 => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide
RHEA:29256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + Na(+)(out) => Ca(2+)(out) + Na(+)(in)
RHEA:57502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-cis-aconitate + H2O => 3-hydroxybutane-1,2,3-tricarboxylate
RHEA:35911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
RHEA:12350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4,5-dihydro-5-oxofuran-2-yl)-acetate => (S)-muconolactone
REACT:R-RNO-2559456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)
RHEA:30001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + spermidine(in) => ATP + H2O + spermidine(out)
RHEA:43123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + xanthine <=> CO2 + succinate + urate
REACT:R-XTR-451056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Microtubule-independent trafficking of connexons to the plasma membrane (Xenopus tropicalis)
REACT:R-SCE-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Saccharomyces cerevisiae)
REACT:R-SSC-1013013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of GABA B receptor with G protein beta-gamma subunits (Sus scrofa)
RHEA:30619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + all-trans-zeta-carotene = 2 AH2 + all-trans-lycopene
RHEA:30619	skos:prefLabel	"all-trans-zeta-carotene desaturase"
RHEA:30619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-zeta-carotene desaturase"
RHEA:30619	skos:altLabel	"phytoene desaturase"
RHEA:30619	skos:altLabel	"2-step phytoene desaturase"
REACT:R-RNO-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Rattus norvegicus)
RHEA:19418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + a dolichyl diphosphate => [phosphate](n+1) + a dolichyl phosphate
REACT:R-MMU-351987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A6-mediated uptake of taurine and beta-alanine (Mus musculus)
REACT:R-RNO-5672329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CLIP1 and microtubules (Rattus norvegicus)
RHEA:13332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxosteroid <=> a 3-oxo-Delta(1)-steroid + AH2
RHEA:54428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]
RHEA:30180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate + oxidized 2[4Fe-4S]-[ferredoxin] => 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:47787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:47586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1c (d18:1(4E)) + H(+) + UDP => ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose
RHEA:22296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate = (1R,2R,3R)-prephytoene diphosphate + diphosphate
GO:0001001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial single-subunit type RNA polymerase binding
REACT:R-GGA-141431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAD2 associates with the Mad1 kinetochore complex (Gallus gallus)
REACT:R-HSA-549304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT3 mediates renal clearance of organic cations (Homo sapiens)
RHEA:58092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)
REACT:R-HSA-9737710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter (Homo sapiens)
REACT:R-MMU-927830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Mus musculus)
REACT:R-CFA-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Canis familiaris)
RHEA:41457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine
EC:3.2.1.174	skos:prefLabel	"rhamnogalacturonan rhamnohydrolase"
EC:3.2.1.174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnogalacturonan rhamnohydrolase"
EC:3.2.1.174	skos:altLabel	"RG alpha-L-rhamnopyranohydrolase"
EC:3.2.1.174	skos:altLabel	"RG-rhamnohydrolase"
REACT:R-RNO-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Rattus norvegicus)
REACT:R-SSC-8850560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha releases G-protein heterotrimer from PDCL  (Sus scrofa)
REACT:R-CEL-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Caenorhabditis elegans)
REACT:R-RNO-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Rattus norvegicus)
REACT:R-DDI-70975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Dictyostelium discoideum)
REACT:R-DRE-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Danio rerio)
REACT:R-DRE-8949580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F1Fo ATP synthase dimerizes (Danio rerio)
REACT:R-MMU-190265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds to FGF (Mus musculus)
RHEA:32175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)
RHEA:18770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfanyl-2,3-dioxopentyl phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate
GO:0033879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	17-O-acetylajmaline O-acetylhydrolase activity
GO:0033879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylajmalan esterase activity
GO:0033879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AAE
GO:0033879	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2beta(R)-17-O-acetylajmalan:acetylesterase activity
GO:0033879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylajmaline esterase activity
REACT:R-DRE-418170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB1 binds MAPKs, SRC-1 (Danio rerio)
REACT:R-BTA-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Bos taurus)
REACT:R-SSC-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Sus scrofa)
REACT:R-GGA-5682084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Gallus gallus)
RHEA:58139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + H(+) <=> acetyl-AMP + diphosphate
GO:0140030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	modification-dependent protein binding
GO:0140030	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	modified protein binding
REACT:R-PFA-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Plasmodium falciparum)
RHEA:17850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O
GO:0015038	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaredoxin
GO:0015038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulfide oxidoreductase activity
GO:0015038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione disulphide oxidoreductase activity
GO:0015038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Homo sapiens)
REACT:R-SSC-2022411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)
RHEA:54468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate
GO:0062037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop DNA binding
GO:0062037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA displacement loop binding
REACT:R-PFA-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Plasmodium falciparum)
REACT:R-CEL-9668902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18-RFC(7s) complex (Caenorhabditis elegans)
REACT:R-MMU-180038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Mus musculus)
RHEA:30872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose + ATP => 2-deoxy-D-ribose 5-phosphate + ADP + H(+)
REACT:R-HSA-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
RHEA:59564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone = H(+) + N,N',N'',N'''-tetraacetylchitotetraonate
RHEA:53020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + an L-alpha-amino acid + H2O = a 2-oxocarboxylate + a plastoquinol + NH4(+)
RHEA:62589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) => 4-hydroxybenzyl alcohol + CO2
RHEA:65603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,5,8-trihydroxycasbene + 2 NAD(+) <=> 2 H(+) + jolkinol C + 2 NADH
REACT:R-CFA-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Canis familiaris)
REACT:R-HSA-5419268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUFM binds GTP displacing TSFM (Homo sapiens)
REACT:R-DRE-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Danio rerio)
REACT:R-SSC-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)
RHEA:63779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-MMU-5690790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H2A is dubiquitinated by the PR-DUB complex (Mus musculus)
RHEA:35615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyacetone + NAD(+) = H(+) + methylglyoxal + NADH
REACT:R-RNO-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Rattus norvegicus)
REACT:R-DRE-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Danio rerio)
RHEA:29840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-idonate + NADP(+) => 2-dehydro-L-idonate + H(+) + NADPH
REACT:R-DRE-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Danio rerio)
RHEA:37296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-threonine(out) => ADP + H(+) + L-alanyl-L-threonine(in) + phosphate
RHEA:36222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-XTR-5228523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates MDM2 with SUMO1 (Xenopus tropicalis)
REACT:R-GGA-9645394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Gallus gallus)
REACT:R-HSA-933526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)
REACT:R-HSA-139920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tBID to mitochondria (Homo sapiens)
REACT:R-CFA-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Canis familiaris)
RHEA:72927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV
REACT:R-HSA-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Homo sapiens)
RHEA:48519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)
REACT:R-DRE-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Danio rerio)
REACT:R-BTA-209738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 binds GC (Bos taurus)
RHEA:28931	skos:prefLabel	"4-oxalomesaconate tautomerase"
RHEA:28931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-oxalomesaconate tautomerase"
RHEA:28931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate
REACT:R-DRE-6799196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Danio rerio)
RHEA:38022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-decanoylglycerol <=> 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-XTR-352182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Xenopus tropicalis)
REACT:R-DME-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
REACT:R-HSA-77612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dsRNA structure by looping  (Homo sapiens)
REACT:R-MMU-9012761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI binds RHOA-GDI (Mus musculus)
RHEA:29858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine <=> D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate
REACT:R-BTA-8857549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HBEGF-bound EGFR forms a heterodimer with GPNMB (Bos taurus)
RHEA:54021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + propanoyl-CoA => CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]
RHEA:34068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate => diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate
REACT:R-SPO-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Schizosaccharomyces pombe)
REACT:R-HSA-1791128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of LMNA (Homo sapiens)
RHEA:32426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + A <=> (R)-carvone + AH2
GO:0102722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-hydroxybutyrate dehydrogenase activity (NAD(P)-dependent
REACT:R-CEL-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Caenorhabditis elegans)
REACT:R-MMU-5669035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF11 binds TNFRSF11A, B (Mus musculus)
REACT:R-RNO-9748979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Rattus norvegicus)
REACT:R-XTR-354077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaIIb beta3 activation (Xenopus tropicalis)
REACT:R-SSC-5662660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopachrome is transformed to DHICA by DCT (Sus scrofa)
REACT:R-SCE-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Saccharomyces cerevisiae)
RHEA:26045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + N-acetyl-9-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate
RHEA:70806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate <=> 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate
REACT:R-HSA-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Homo sapiens)
REACT:R-HSA-2730843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LAT by p-SYK (Homo sapiens)
REACT:R-SSC-3204311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOX1 oxidises PXL to PDXate (Sus scrofa)
REACT:R-MMU-381543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP4 binds IGF forming IGF:IGFBP4 (Mus musculus)
REACT:R-SSC-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Sus scrofa)
RHEA:12058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + 2 H(+) + NADH => D-erythrose 4-phosphate + H2O + NAD(+)
REACT:R-SSC-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Sus scrofa)
RHEA:45918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA
RHEA:27715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H2O => guanosine + phosphate
RHEA:19226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]
EC:1.4.3.7	skos:altLabel	"D-glutamic oxidase"
EC:1.4.3.7	skos:prefLabel	"D-glutamate oxidase"
EC:1.4.3.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glutamate oxidase"
REACT:R-XTR-170796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports GCK1:GKRP from cytosol to nucleoplasm (Xenopus tropicalis)
RHEA:33004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:18913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)
RHEA:18913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)
RHEA:29005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-homoserine(out) => H(+)(out) + L-homoserine(in)
RHEA:45721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hexadecanoylsphing-4-enine(in) => N-hexadecanoylsphing-4-enine(out)
REACT:R-XTR-8875531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS4 (Xenopus tropicalis)
REACT:R-BTA-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Bos taurus)
REACT:R-CFA-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Canis familiaris)
RHEA:47396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanoate ester = an aliphatic alcohol + H(+) + octadecanoate
REACT:R-CEL-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Caenorhabditis elegans)
REACT:R-DME-209924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is decarboxylated to dopamine (Drosophila melanogaster)
REACT:R-HSA-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Homo sapiens)
RHEA:29484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-beta-selinene + diphosphate
REACT:R-SPO-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Schizosaccharomyces pombe)
REACT:R-XTR-202727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaMbeta2 (MAC1) binds JAM3 (Xenopus tropicalis)
RHEA:55640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)
RHEA:38561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate
REACT:R-MMU-199046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligands bind L-selectin (Mus musculus)
RHEA:49627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + erythritol <=> ADP + D-erythritol 1-phosphate + H(+)
GO:0098624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylylselenate reductase activity
GO:0098624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSe is reduced to SeO3(2-) by PAPSe reductase (Homo sapiens)
GO:0098624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSe reductase activity
REACT:R-RNO-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)
REACT:R-DDI-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Dictyostelium discoideum)
REACT:R-CEL-390251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)
RHEA:40294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + tetradecanedioate <=> AMP + diphosphate + tetradecanedioyl-CoA
REACT:R-DME-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Drosophila melanogaster)
REACT:R-BTA-451377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IQGAP1 with nephrin (Bos taurus)
RHEA:48385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated fatty acid + H2O2 => a 3-hydroxy fatty acid + H2O
REACT:R-CFA-8960973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1:11cRAL dissociates (Canis familiaris)
RHEA:33892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chanoclavine-I + NAD(+) => chanoclavine-I aldehyde + H(+) + NADH
RHEA:29564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
REACT:R-CFA-432143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM-1 binds PP2A (Canis familiaris)
REACT:R-RNO-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Rattus norvegicus)
REACT:R-CFA-170055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Canis familiaris)
REACT:R-GGA-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Gallus gallus)
RHEA:15698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Rattus norvegicus)
REACT:R-PFA-446207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Plasmodium falciparum)
RHEA:48364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
REACT:R-MMU-5618110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Mus musculus)
GO:0090655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded/single-stranded junction telomeric DNA binding
REACT:R-BTA-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Bos taurus)
RHEA:55960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate + ATP + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA
RHEA:55960	skos:prefLabel	"carnitine--CoA ligase"
RHEA:55960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnitine--CoA ligase"
REACT:R-HSA-9724290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR2 binds GNRH1,2 (Homo sapiens)
REACT:R-DRE-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Danio rerio)
RHEA:39691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH = (11Z)-octadecenoyl-CoA + NADP(+)
REACT:R-CEL-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Caenorhabditis elegans)
GO:0032553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleotide binding
REACT:R-DRE-416725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA6D binds to PLXNA1:TREM2:DAP12 (Danio rerio)
REACT:R-XTR-9603420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK3 promotes SRC autophosphorylation (Xenopus tropicalis)
REACT:R-GGA-5624130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylated NPHP3 translocates into the ciliary membrane (Gallus gallus)
REACT:R-RNO-2130504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of lip22 to lip10 (Rattus norvegicus)
REACT:R-RNO-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Rattus norvegicus)
RHEA:21870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+) => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O
RHEA:37356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + uridine 2'-phosphate => phosphate + uridine
RHEA:51088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DDI-5687107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to nucleus (Dictyostelium discoideum)
RHEA:30097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + oxaloacetate => (S)-malate + a menaquinone
REACT:R-SSC-1247497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds neuregulins (Sus scrofa)
REACT:R-MMU-173631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1s (Mus musculus)
GO:0033787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyanocobalamin reductase activity
GO:0033787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanocobalamin reductase (cyanide-eliminating) activity
GO:0033787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyanocobalamin reductase (NADPH; CN-eliminating) activity
GO:0033787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cob(I)alamin, cyanide:NADP+ oxidoreductase activity
GO:0033787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity
GO:0033787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity
GO:0033787	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyanocobalamin reductase (NADPH, cyanide-eliminating) activity
GO:0018643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon disulphide oxygenase activity
GO:0018643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon disulfide oxygenase activity
REACT:R-CEL-69562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)
RHEA:66005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] => Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M
RHEA:47212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisoheptadecanoyl-CoA + NADP(+) <=> 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH
RHEA:46015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + a quinone <=> a quinol + oxaloacetate
RHEA:20438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5D-5-O-methyl-chiro-inositol + NADP(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH
GO:0106437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate
GO:0106437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glutamic acid ligase activity, initiating
RHEA:44278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA => eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA
RHEA:53041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-BTA-9023633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Bos taurus)
REACT:R-SCE-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)
RHEA:29192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + menaquinone-8 => iminosuccinate + menaquinol-8
REACT:R-BTA-1793207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses C4S/C6S chains (Bos taurus)
RHEA:35306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisopentadecanoyl-CoA + NADP(+) <=> 3-oxoisopentadecanoyl-CoA + H(+) + NADPH
REACT:R-HSA-8950405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Homo sapiens)
EC:2.4.2.47	skos:prefLabel	"arabinofuranan 3-O-arabinosyltransferase"
EC:2.4.2.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arabinofuranan 3-O-arabinosyltransferase"
REACT:R-GGA-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Gallus gallus)
REACT:R-CFA-9708423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1:BACH1:Hemes are transported out of the nucleus (Canis familiaris)
REACT:R-HSA-9624985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAV1 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
REACT:R-BTA-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Bos taurus)
REACT:R-XTR-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Xenopus tropicalis)
RHEA:18112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate
RHEA:61279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-ornithine + O2 <=> 5-amino-2-oxopentanoate + H2O2 + NH4(+)
RHEA:14659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate => aldehydo-D-ribose 5-phosphate
REACT:R-MMU-9695890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Mus musculus)
REACT:R-MMU-5654690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
REACT:R-PFA-5690827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 (Plasmodium falciparum)
REACT:R-MMU-5654422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS2 (Mus musculus)
RHEA:36135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH
RHEA:27610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) = CO2 + H2
RHEA:60273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-DRE-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Danio rerio)
RHEA:43101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) => 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine
REACT:R-SPO-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Schizosaccharomyces pombe)
RHEA:16349	skos:prefLabel	"chlorate reductase"
RHEA:16349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorate reductase"
RHEA:16349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + chlorate = A + chlorite + H2O
RHEA:67165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + FADH2 + melleolide F + O2 => 6'-bromomelleolide F + FAD + 2 H2O
REACT:R-DRE-8984014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Danio rerio)
REACT:R-SSC-5693583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDC1 associates with gamma-H2AFX at nuclear foci (Sus scrofa)
RHEA:17459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine => [sulfur-carrier protein]-L-cysteine + L-cysteine
RHEA:62484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:66973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose => alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)
RHEA:43665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + tetracosanoyl-CoA => 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate
REACT:R-SSC-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Sus scrofa)
REACT:R-RNO-420489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parathyroid hormone receptor can bind parathyroid hormone (Rattus norvegicus)
RHEA:15511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-RNO-914018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Rattus norvegicus)
REACT:R-HSA-2294580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 hyperphosphorylates Condensin II complex (Homo sapiens)
REACT:R-XTR-432688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Xenopus tropicalis)
RHEA:16272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) <=> 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH
REACT:R-BTA-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Bos taurus)
REACT:R-HSA-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Homo sapiens)
GO:0047892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavone apiosyltransferase activity
GO:0047892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoapiose-flavone apiosyltransferase activity
GO:0047892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity
GO:0047892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity
RHEA:21733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + L-glutamine => anthranilate + H(+) + L-glutamate + pyruvate
RHEA:48639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O
REACT:R-DRE-8940554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2 cleaves OPTC (Danio rerio)
RHEA:37569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine
REACT:R-BTA-2066299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 binds phosphorylated WWTR1 (TAZ) (Bos taurus)
REACT:R-HSA-1433395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of sSCF (Homo sapiens)
RHEA:47851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate
REACT:R-DRE-5654655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PPTN11 (Danio rerio)
REACT:R-XTR-1234173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)
REACT:R-SSC-870479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) binds to ubiquitinated SMAD4 (Sus scrofa)
RHEA:66695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-rhamnose + L-arginyl-[protein] <=> dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]
REACT:R-BTA-2465924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1LW binds 11cRAL (Bos taurus)
RHEA:56597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-bornane-2,5-dione + FMNH2 + O2 => (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O
REACT:R-MMU-1370505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR is phosphorylated at Ser-349 (Mus musculus)
REACT:R-XTR-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Xenopus tropicalis)
RHEA:65420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP(in) + NAD(+)(out) = GMP(out) + NAD(+)(in)
REACT:R-SPO-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Schizosaccharomyces pombe)
REACT:R-CFA-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Canis familiaris)
REACT:R-SPO-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Schizosaccharomyces pombe)
RHEA:33828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol => vitamin D2
REACT:R-MMU-8948018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Mus musculus)
REACT:R-DDI-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Dictyostelium discoideum)
REACT:R-MMU-9754934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Mus musculus)
REACT:R-DME-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
GO:0036487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide synthase inhibitor activity
GO:0036487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOS inhibitor activity
GO:0036487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric-oxide synthase inhibitor activity
RHEA:56354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+) => 4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2
RHEA:22219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + O2 <=> 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)
EC:5.6.1.7	skos:prefLabel	"chaperonin ATPase"
EC:5.6.1.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chaperonin ATPase"
EC:5.6.1.7	skos:altLabel	"chaperonin"
GO:0036402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteasome-activating activity
GO:0036402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase involved in positive regulation of proteasomal protein catabolic process
GO:0036402	skos:prefLabel	"proteasome ATPase"
GO:0036402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"proteasome ATPase"
GO:0036402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteasome-activating ATPase activity
GO:0036402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteasomal ATPase activity
GO:0036402	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proteasome channel gating activity
GO:0036402	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proteasome channel opening activity
REACT:R-DME-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Drosophila melanogaster)
REACT:R-SSC-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Sus scrofa)
RHEA:35816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate
RHEA:10947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + psi-UMP <=> phosphate + pseudouridine
RHEA:50988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin F2alpha(out) = prostaglandin F2alpha(in)
RHEA:58138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-AMP + diphosphate => acetate + ATP + H(+)
REACT:R-MMU-5362437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are bound by lectins (Mus musculus)
REACT:R-XTR-6807224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-BGLAP to BGLAP (Xenopus tropicalis)
REACT:R-CFA-5610720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI3 (Canis familiaris)
RHEA:33117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(out) => malonate(in)
REACT:R-HSA-8950328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Peptidyl-prolyl cis-trans isomerase A (Homo sapiens)
REACT:R-HSA-8962050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYMS gene expression (Homo sapiens)
GO:1901683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate ion transmembrane transporter activity
REACT:R-GGA-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Gallus gallus)
REACT:R-HSA-9637641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rv2779c binds TLR2 (Homo sapiens)
REACT:R-RNO-5669035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF11 binds TNFRSF11A, B (Rattus norvegicus)
REACT:R-DRE-200143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates AKT1S1 (PRAS40) (Danio rerio)
GO:1904517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MgATP(2-) binding
REACT:R-GGA-1112565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Gallus gallus)
REACT:R-MMU-189398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 dimer, HMOX2 cleave heme (Mus musculus)
GO:0047320	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity
GO:0047320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-4-hydroxyphenylglycine transaminase activity
GO:0047320	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-hydroxyphenylglycine aminotransferase activity
GO:0047320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-4-hydroxyphenylglycine aminotransferase activity
RHEA:37195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:40261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O
RHEA:37455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-2426160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds the ACACA promoter (Homo sapiens)
REACT:R-SCE-548843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligate CoA to AA to form AA-CoA (Saccharomyces cerevisiae)
RHEA:44641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + ATP => a 2'-deoxyribonucleoside 5'-triphosphate + ADP
RHEA:40869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9E)-octadecadienoyl-CoA + FADH2 => (9E)-octadecenoyl-CoA + FAD + H(+)
REACT:R-GGA-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Gallus gallus)
RHEA:37117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoyl-CoA
RHEA:16209	skos:prefLabel	"cobalt-precorrin-8 methylmutase"
RHEA:16209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobalt-precorrin-8 methylmutase"
RHEA:16209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-8X = cob(II)yrinate
RHEA:62583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-cystine(out) + H2O <=> ADP + D-cystine(in) + H(+) + phosphate
REACT:R-SSC-450063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Sus scrofa)
RHEA:30178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 2 plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9
RHEA:15940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + NADP(+) <=> an aldehyde + H(+) + NADPH
REACT:R-DRE-8874849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBRF binds CREB3 (Danio rerio)
REACT:R-DDI-1482545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Dictyostelium discoideum)
GO:0030546	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	receptor activator activity
GO:0030546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signalling receptor activator activity
GO:0030546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	signaling receptor activator activity
REACT:R-SPO-9668335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds LEMD2 (Schizosaccharomyces pombe)
REACT:R-GGA-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Gallus gallus)
RHEA:51506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP => a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose
RHEA:55477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine
RHEA:20494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-HSA-5668534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
RHEA:69355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (E)-prop-1-en-1-SO-peroxol <=> H2O + thiosulfinate
RHEA:19718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-phenylalanine => 2-phenylethylamine + CO2
RHEA:56785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O => (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate
RHEA:14805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-allose = ADP + D-allose 6-phosphate + H(+)
RHEA:14805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"allose kinase"
RHEA:14805	skos:prefLabel	"allose kinase"
RHEA:14805	skos:altLabel	"allokinase"
RHEA:12296	skos:prefLabel	"deacetylipecoside synthase"
RHEA:12296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deacetylipecoside synthase"
RHEA:12296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylipecoside + H2O = dopamine + secologanin
RHEA:10777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH
REACT:R-DDI-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Dictyostelium discoideum)
RHEA:45398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:33286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxycyclohexan-1-one + NADPH + O2 <=> 6-oxohexanoate + H2O + NADP(+)
REACT:R-BTA-3295580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPM4,5 transport extracellular Na+ to cytosol (Bos taurus)
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3',5'-cyclonucleotide phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside 3',5'-cyclic phosphate diesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3',5'-nucleotide phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic 3',5'-phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic 3',5'-mononucleotide phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic 3',5-nucleotide monophosphate phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic 3',5'-nucleotide phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5' cyclic-nucleotide phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclic AMP phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclic nucleotide phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleoside-3',5-monophosphate phosphodiesterase activity
GO:0004114	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDE
RHEA:68386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate => (2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein]
RHEA:45936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA
GO:0015039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH-adrenodoxin reductase activity
GO:0015039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenodoxin-type ferredoxin reductase activity
GO:0015039	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	adrenodoxin reductase activity
GO:0015039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:adrenodoxin oxidoreductase activity
REACT:R-SSC-977629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of C2a/Bb by CR1 (Sus scrofa)
REACT:R-CFA-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Canis familiaris)
RHEA:41511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine + NADPH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NADP(+)
REACT:R-MMU-6814683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Mus musculus)
REACT:R-XTR-9668904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18 complex (Xenopus tropicalis)
REACT:R-MMU-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Mus musculus)
RHEA:23254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O
RHEA:47036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine in 5S rRNA = pseudouridine in 5S rRNA
RHEA:61435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH
GO:0035939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microsatellite binding
GO:0035939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VNTR binding
GO:0035939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	variable number tandem repeat binding
GO:0035939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microsatellite DNA binding
RHEA:60366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + myo-inositol(in) => H(+)(out) + myo-inositol(out)
REACT:R-BTA-73598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Bos taurus)
REACT:R-GGA-6800380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds IL1RAP-1 (Gallus gallus)
RHEA:10059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-aminobutanoyl-CoA <=> (2E)-butenoyl-CoA + NH4(+)
REACT:R-HSA-2029989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of overexpressed FGFR2 variants (Homo sapiens)
REACT:R-HSA-5333609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSebGalNac is hydrolysed to MeSeH and bGalNac (Homo sapiens)
REACT:R-XTR-6807027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 and PTPN2 dephosphorylate MET (Xenopus tropicalis)
REACT:R-RNO-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Rattus norvegicus)
REACT:R-MMU-8987063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Mus musculus)
REACT:R-XTR-3361751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-catenin is replaced by repression complexes at the promoter (Xenopus tropicalis)
REACT:R-BTA-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Bos taurus)
RHEA:25637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + sulfoacetaldehyde = 2 H(+) + NADH + sulfoacetate
RHEA:25637	skos:prefLabel	"sulfoacetaldehyde dehydrogenase"
RHEA:25637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfoacetaldehyde dehydrogenase"
REACT:R-DME-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Drosophila melanogaster)
REACT:R-CEL-3788061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by ADAM8 (Caenorhabditis elegans)
RHEA:50343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone <=> 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CEL-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Caenorhabditis elegans)
GO:0106411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP 5'-nucleosidase activity
REACT:R-XTR-2066299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL2 binds phosphorylated WWTR1 (TAZ) (Xenopus tropicalis)
RHEA:47742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + demethylphylloquinone + diphosphate => 1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate
REACT:R-GGA-5654587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS phosphorylates PPTN11 (Gallus gallus)
RHEA:52449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-SCE-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Saccharomyces cerevisiae)
RHEA:58673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate => aldehydo-D-glucuronate
RHEA:26173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA => CoA + H(+) + mycothiol
GO:0004768	skos:prefLabel	"stearoyl-CoA 9-desaturase"
GO:0004768	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fatty acid desaturase
GO:0004768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0004768	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	delta(9)-desaturase activity
GO:0004768	skos:altLabel	"fatty acid desaturase"
GO:0004768	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acyl-CoA desaturase
GO:0004768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stearoyl-CoA 9-desaturase"
GO:0004768	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	stearoyl-CoA desaturase activity
GO:0004768	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	delta9-desaturase
GO:0004768	skos:altLabel	"acyl-CoA desaturase"
GO:0004768	skos:altLabel	"stearoyl-CoA desaturase"
GO:0004768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stearoyl-CoA 9-desaturase activity
GO:0004768	skos:altLabel	"Delta(9)-desaturase"
REACT:R-GGA-5633040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Gallus gallus)
REACT:R-GGA-8850529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGS proteins bind GNB5 and CCT/TRiC (Gallus gallus)
REACT:R-SPO-68954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm2-7 is phosphorylated by DDK (Schizosaccharomyces pombe)
RHEA:67194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate => ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out)
RHEA:15626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-6B + NAD(+) => Co-precorrin-6A + H(+) + NADH
RHEA:45660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
RHEA:47107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + glycine + H2O <=> 5,6,7,8-tetrahydromethanopterin + L-serine
RHEA:19454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-alanine => L-glutamate + pyruvate
RHEA:15587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 AH2 + all-trans-lycopene => 15-cis-phytoene + 4 A
REACT:R-BTA-9654533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B recycles to the plasma membrane (Bos taurus)
RHEA:16882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate
RHEA:65924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-141351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAOX:FAD oxidises NASPN to SPM (Homo sapiens)
REACT:R-XTR-5654640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)
REACT:R-MMU-372505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylcholine synaptic vesicle docking and priming (Mus musculus)
RHEA:45364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine = (11Z)-eicosenoate + (4R)-hydroxysphinganine
RHEA:67674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-RNO-9614273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGRG heterodimer translocates to plasma membrane (Rattus norvegicus)
RHEA:72971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline(out) + 2 Na(+)(out) = 5-oxo-L-proline(in) + 2 Na(+)(in)
RHEA:45018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-selenomethionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine
RHEA:12250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => NADP(+) + UDP-N-acetyl-alpha-D-muramate
RHEA:43970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O
RHEA:50907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine
REACT:R-RNO-9021627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
RHEA:59770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
RHEA:36831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caldariellaquinol oxidase (H(+)-transporting)"
RHEA:36831	skos:altLabel	"aa3 quinol oxidase"
RHEA:36831	skos:altLabel	"aa3-type quinol oxidase"
RHEA:36831	skos:prefLabel	"caldariellaquinol oxidase (H(+)-transporting)"
RHEA:36831	skos:altLabel	"cytochrome aa3"
RHEA:36831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 caldariellaquinol + n H(+)(in) + O2 = 2 caldariellaquinone + n H(+)(out) + 2 H2O
RHEA:36831	skos:altLabel	"cytochrome aa3-type oxidase"
RHEA:36831	skos:altLabel	"terminal quinol oxidase"
REACT:R-HSA-450063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Homo sapiens)
REACT:R-HSA-216757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Homo sapiens)
RHEA:38422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate
REACT:R-DME-391943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLT2 binds LTC4,LTD4,LTE4 (Drosophila melanogaster)
REACT:R-MMU-74247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Mus musculus)
REACT:R-CFA-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Canis familiaris)
REACT:R-BTA-3296304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR31 is a receptor for 12(S)-HETE (Bos taurus)
REACT:R-SSC-8878056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds EP300 (Sus scrofa)
RHEA:65785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:64898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 phosphate + UMP => 2 H2O + UTP
RHEA:12346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-glutamyl-tRNA(Glu) + NADPH => (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu)
REACT:R-SSC-211991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclophosphamide is 4-hydroxylated by CYP2B6 (Sus scrofa)
RHEA:45284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + sphing-4-enine = CoA + H(+) + N-eicosanoyl-sphing-4-enine
REACT:R-BTA-202969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of beta-catenin (Bos taurus)
REACT:R-MMU-5696220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to arsenite(3-) (Mus musculus)
REACT:R-SSC-3640862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase binds AXIN (Sus scrofa)
REACT:R-BTA-9624778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD 12mer translocates from ER membrane to extracellular region (Bos taurus)
RHEA:31894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1-phenyl-1-propanone + NADP(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADPH
REACT:R-CFA-9614414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Canis familiaris)
REACT:R-MMU-5226964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKH transports PPi from cytosol to extracellular region (Mus musculus)
GO:0017166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vinculin binding
REACT:R-HSA-8964271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in PIP3:BTK:G beta-gamma complex is activated (Homo sapiens)
RHEA:60201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate
RHEA:28540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A
RHEA:24962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[excited state blue fluorescent protein] + CO2 => apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2
REACT:R-DRE-2029468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PA into DAG by PAP-1 (Danio rerio)
REACT:R-PFA-9678925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 binds NR3C1 agonists (Plasmodium falciparum)
REACT:R-DRE-202437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CARMA1 (Danio rerio)
REACT:R-DDI-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Dictyostelium discoideum)
REACT:R-SSC-8948234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB:4-Hyp collagen propeptides dissociates (Sus scrofa)
RHEA:65461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hexan-1-ol => CoA + hexyl acetate
RHEA:40630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trihexadecanoylglycerol <=> 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate
RHEA:32420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R,4R)-neoisodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH
RHEA:18660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NADP(+) <=> 3-hydroxypyruvate + H(+) + NADPH
REACT:R-BTA-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Bos taurus)
RHEA:64639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + butan-1-ol <=> butyl benzoate + CoA
RHEA:11725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite => 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol
REACT:R-RNO-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Rattus norvegicus)
REACT:R-GGA-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Gallus gallus)
REACT:R-RNO-983146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Rattus norvegicus)
REACT:R-DRE-3159253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAB adenosylates cob(I)alamin (Danio rerio)
REACT:R-MMU-448673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of caspase-1 p10/p20 dimer (Mus musculus)
REACT:R-XTR-2024084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS-GAGs translocate to the lysosome for degradation (Xenopus tropicalis)
RHEA:35484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine
RHEA:41769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) => CMP + ganglioside GT1a (d18:1(4E)) + H(+)
RHEA:67053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + asnovolin J + O2 => A + asnovolin A + H2O
REACT:R-HSA-8936442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARC1,MARC2 reduce N-hydroxylated compounds (Homo sapiens)
REACT:R-MMU-444202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR1 binds free fatty acids (Mus musculus)
REACT:R-MMU-8875659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Mus musculus)
RHEA:42214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O
RHEA:31016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-carboxylate => CO2 + indole
RHEA:64237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrochrysone carboxyl-[ACP] + H2O => atrochrysone carboxylate + H(+) + holo-[ACP]
REACT:R-DME-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Drosophila melanogaster)
RHEA:11282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O
RHEA:36393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmosterol + H(+) + NADPH => cholesterol + NADP(+)
REACT:R-DRE-9663492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL dissociates from GSTA1, FABP1 (Danio rerio)
REACT:R-CFA-5696101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)
GO:0120022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glucagon-like peptide binding
GO:0120022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glucagon binding
GO:0120022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucagon family peptide binding
EC:2.3.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring groups other than amino-acyl groups"
EC:2.3.1.-	skos:prefLabel	"Transferring groups other than amino-acyl groups"
RHEA:65442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine
RHEA:58578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + precondylocarpine acetate => dihydroprecondylocarpine acetate + NADP(+)
REACT:R-CEL-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Caenorhabditis elegans)
REACT:R-SSC-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Sus scrofa)
RHEA:22485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => GMP + GTP + 2 H(+)
REACT:R-GGA-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Gallus gallus)
RHEA:21240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]
RHEA:66995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylpentanoate + ATP + CoA <=> 3-methylpentanoyl-CoA + AMP + diphosphate
REACT:R-DDI-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Dictyostelium discoideum)
REACT:R-BTA-9686088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDMD (Bos taurus)
RHEA:38652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)
REACT:R-RNO-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Rattus norvegicus)
REACT:R-CFA-417820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 receptor can bind to LPA (Canis familiaris)
RHEA:60312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:34366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-HSA-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
REACT:R-GGA-5693575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PKcs autophosphorylates (Gallus gallus)
RHEA:48934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GQ1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b
REACT:R-GGA-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Gallus gallus)
REACT:R-GGA-421197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate (AMP) + fumarate (Gallus gallus)
GO:0010486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	manganese:hydrogen antiporter activity
GO:0010486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	manganese:proton antiporter activity
REACT:R-BTA-77585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Bos taurus)
REACT:R-HSA-140978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex binds FADD (Homo sapiens)
REACT:R-CFA-8853762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET dimerizes (Canis familiaris)
GO:0047669	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose-glucan glucosyltransferase activity
GO:0047669	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity
GO:0047669	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose-1,4-alpha-glucan glucosyltransferase activity
GO:0047669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amylosucrase activity
REACT:R-DRE-5626962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB2L1 binds IKKA:IKKB:NEMO (Danio rerio)
REACT:R-DRE-1861788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) (Danio rerio)
RHEA:39291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA
RHEA:63318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2
REACT:R-CEL-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Caenorhabditis elegans)
REACT:R-GGA-1226094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Gallus gallus)
RHEA:15910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + taurine => aminoacetaldehyde + CO2 + H(+) + succinate + sulfite
GO:0047439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-manno-octulosonic aldolase activity
GO:0047439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KDOaldolase activity
GO:0047439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-manno-octulosonate aldolase activity
GO:0047439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxyoctonic aldolase activity
GO:0047439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxyoctulosonic aldolase activity
GO:0047439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxyoctonate aldolase activity
GO:0047439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)
GO:0047439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-manno-octulosonate D-arabinose-lyase activity
GO:0008743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine 3-dehydrogenase activity
GO:0008743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine:NAD+ oxidoreductase activity
GO:0008743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine dehydrogenase activity
GO:0008743	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-threonine dehydrogenase activity
GO:0008743	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	threonine 3-dehydrogenase activity
RHEA:52964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP
GO:0047200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity
GO:0047200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydrodipicolinate N-acetyltransferase activity
GO:0047200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity
GO:0047200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity
GO:0047200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity
GO:0047200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrodipicolinate acetylase activity
REACT:R-BTA-109387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)
REACT:R-RNO-176264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Rattus norvegicus)
REACT:R-XTR-5626316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Xenopus tropicalis)
REACT:R-CEL-202947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of APC (Caenorhabditis elegans)
REACT:R-CEL-5228508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates PML with SUMO1 (Caenorhabditis elegans)
REACT:R-HSA-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)
RHEA:38926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H(+) + Na(+)(in) + NADH <=> a ubiquinol + Na(+)(out) + NAD(+)
GO:0046563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanol oxidase activity
REACT:R-BTA-5205661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is recruited from the cytoplasm to the mitochondria (Bos taurus)
GO:0030619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U1 snRNA binding
RHEA:58555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate II + H2O <=> (16R)-deshydroxymethyl-stemmadenine + formate
REACT:R-CFA-450358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Canis familiaris)
REACT:R-RNO-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Rattus norvegicus)
REACT:R-MMU-1855211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
REACT:R-HSA-168862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of HA into rafts (Homo sapiens)
REACT:R-GGA-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Gallus gallus)
RHEA:62398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2S)-pseudoephedrine + NAD(+)
RHEA:58711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin ortho-naphthoquinone carboxamide <=> rifampicin para-naphthoquinone carboxamide
REACT:R-BTA-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Bos taurus)
REACT:R-CEL-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Caenorhabditis elegans)
REACT:R-XTR-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Xenopus tropicalis)
REACT:R-HSA-1296043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of HCN channels (Homo sapiens)
REACT:R-SSC-446130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 2 binds Interleukin 1 (Sus scrofa)
REACT:R-SSC-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Sus scrofa)
RHEA:57428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anisole + O2 + reduced [NADH--hemoprotein reductase] = formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol
REACT:R-CFA-8865237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD6 methylates RELA in the NFkB complex (Canis familiaris)
RHEA:44919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-decadienoyl-CoA + H(+) + NADPH <=> (3E)-decenoyl-CoA + NADP(+)
RHEA:58650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV hemiaminal
RHEA:36445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,8-dimethyl-6,7-didehydroergoline + H2O => dihydrochanoclavine-I aldehyde
RHEA:30320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NAD(+)
RHEA:70843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-methionine(out) + Na(+)(out) = L-arginine(out) + L-methionine(in) + Na(+)(in)
GO:0030766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tabersonine 16-O-methyltransferase activity
GO:0030766	skos:altLabel	"S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase"
GO:0030766	skos:prefLabel	"tabersonine 16-O-methyltransferase"
GO:0030766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity
GO:0030766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine
GO:0030766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity
GO:0030766	skos:altLabel	"11-demethyl-17-deacetylvindoline 11-methyltransferase"
GO:0030766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tabersonine 16-O-methyltransferase"
GO:0030766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	11-demethyl-17-deacetylvindoline 11-methyltransferase activity
GO:0030766	skos:altLabel	"11-O-demethyl-17-O-deacetylvindoline O-methyltransferase"
GO:0030766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity
REACT:R-BTA-3772430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNBIP1 binds beta-catenin (Bos taurus)
REACT:R-RNO-2160915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor-mediated uptake of HA (Rattus norvegicus)
REACT:R-DME-8953946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Drosophila melanogaster)
GO:0052684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity
GO:0052684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine hydro-lyase (adding indole; L-tryptophan-forming) activity
GO:0052684	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	tryptophan synthase beta subunit activity
REACT:R-GGA-5654594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)
REACT:R-DRE-390909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds hist (Danio rerio)
GO:0008494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation activator activity
REACT:R-BTA-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Bos taurus)
REACT:R-SPO-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Schizosaccharomyces pombe)
REACT:R-DDI-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Dictyostelium discoideum)
EC:3.4.22.40	skos:prefLabel	"bleomycin hydrolase"
EC:3.4.22.40	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"bleomycin hydrolase"
EC:3.4.22.40	skos:altLabel	"aminopeptidase C (Lactococcus lactis)"
REACT:R-CFA-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Canis familiaris)
REACT:R-HSA-5683588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 transfers ATG12 from ATG10 to ATG5 (Homo sapiens)
REACT:R-SPO-428701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Schizosaccharomyces pombe)
RHEA:71945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + 3 Na(+)(in) => (S)-malate(out) + 3 Na(+)(out)
REACT:R-CFA-449058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family are secreted (Canis familiaris)
GO:0047774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-2-enoyl-coenzyme A reductase activity
GO:0047774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-2-enoyl-CoA reductase (NADPH) activity
GO:0047774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:NADP+ cis-2-oxidoreductase activity
GO:0047774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent cis-enoyl-CoA reductase activity
GO:0047774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, cis-2-enoyl coenzyme A
RHEA:14660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate <=> D-ribulose 5-phosphate
REACT:R-RNO-2230938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin:Haptoglobin:CD163 is endocytosed (Rattus norvegicus)
RHEA:21052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH
RHEA:21052	skos:altLabel	"2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase"
RHEA:21052	skos:prefLabel	"2-(S)-hydroxypropyl-CoM dehydrogenase"
RHEA:21052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-(S)-hydroxypropyl-CoM dehydrogenase"
RHEA:46403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]
RHEA:23478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
RHEA:47479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-tetradecenoyl-CoA <=> (2E)-tetradecenoyl-CoA
REACT:R-DRE-2248891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARSA translocates to the lysosome (Danio rerio)
REACT:R-HSA-4084989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)
REACT:R-SCE-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Saccharomyces cerevisiae)
RHEA:56873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-acetyl-1-phenylethylamine + H2O => (S)-1-phenylethylamine + acetate
REACT:R-SSC-2872444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9B1/C2 exchange Na+ for H+ (Sus scrofa)
RHEA:57058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-apionolactone + H(+) + NADH => D-apiofuranose + NAD(+)
GO:0022809	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ionophore
GO:0022809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mobile ion carrier activity
RHEA:47300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0034954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphenyl ether 2,3-dioxygenase activity
REACT:R-DDI-6811411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the Golgi (Dictyostelium discoideum)
REACT:R-DME-170153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)
REACT:R-HSA-1678650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses Heparan sulfate chain(5) (Homo sapiens)
GO:1990472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	piRNA dual-strand cluster binding
RHEA:54268	skos:altLabel	"HIF hydroxylase"
RHEA:54268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate
RHEA:54268	skos:prefLabel	"hypoxia-inducible factor-asparagine dioxygenase"
RHEA:54268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hypoxia-inducible factor-asparagine dioxygenase"
REACT:R-MMU-3371554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 acetylation at Lys80 (Mus musculus)
RHEA:54193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
REACT:R-HSA-9656775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysmethynil binds ICMT:Zn2+ (Homo sapiens)
REACT:R-HSA-212269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Homo sapiens)
REACT:R-MMU-8854293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A (EPI64) binds ARF6:GTP (Mus musculus)
GO:0004766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine aminopropyltransferase activity
GO:0004766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity
GO:0004766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SpeE
GO:0004766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	spermidine synthetase activity
GO:0004766	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminopropyltransferase activity
GO:0004766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine synthase activity
RHEA:39110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
GO:0004860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein kinase inhibitor activity
REACT:R-CFA-71164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 => maleylacetoacetate (Canis familiaris)
REACT:R-HSA-9696179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Homo sapiens)
REACT:R-DME-6811479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 recruits EP300 to TP53 (Drosophila melanogaster)
REACT:R-SPO-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Schizosaccharomyces pombe)
RHEA:20675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+)
GO:0047512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-butanediol dehydrogenase activity
GO:0047512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-BDH
GO:0047512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity
GO:0047512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-butanediol dehydrogenase activity
GO:0047512	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)
REACT:R-RNO-68947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 enters the cytosol (Rattus norvegicus)
REACT:R-HSA-139941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IP3 to IP3 receptor (Homo sapiens)
REACT:R-BTA-212007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1 4-hydroxylate atRA (Bos taurus)
REACT:R-GGA-9008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37, IL37(?-218) translocates from cytosol to extracellular region (Gallus gallus)
RHEA:50124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D1 = 8-oxoresolvin D1 + H(+) + NADH
RHEA:50630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmalate
RHEA:35854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
GO:0140764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small RNA binding translational repressor activity
RHEA:14650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethyllactenocin + dTDP-beta-L-mycarose => demethylmacrocin + dTDP + H(+)
REACT:R-DME-5654169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR4 (Drosophila melanogaster)
REACT:R-MMU-266051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HpETE is dehydrated to LTA4 by ALOX5 (Mus musculus)
RHEA:24343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R,R)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + H(+) + NADH
REACT:R-MMU-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Mus musculus)
REACT:R-DDI-209772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to triiodothyronine (Dictyostelium discoideum)
RHEA:66188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate
RHEA:61347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine + O2 <=> 3-hydroxypyruvate + H2O2 + NH4(+)
RHEA:17583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O
REACT:R-BTA-3780997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG2:GYS2 (Bos taurus)
REACT:R-DRE-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Danio rerio)
REACT:R-CFA-8983870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Canis familiaris)
REACT:R-DRE-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Danio rerio)
RHEA:15591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylglyoxylate + L-glutamate => 2-oxoglutarate + D-4-hydroxyphenylglycine
RHEA:12168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allyl alcohol + NADP(+) = acrolein + H(+) + NADPH
RHEA:12168	skos:prefLabel	"allyl-alcohol dehydrogenase"
RHEA:12168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"allyl-alcohol dehydrogenase"
RHEA:59954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dimethylheptanoate + CoA + H(+) => 2,6-dimethylheptanoyl-CoA + H2O
RHEA:17138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 => thromboxane A2
RHEA:11240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + thiamine diphosphate = ADP + thiamine triphosphate
RHEA:11240	skos:prefLabel	"thiamine-diphosphate kinase"
RHEA:11240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiamine-diphosphate kinase"
REACT:R-BTA-3697882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN (Bos taurus)
RHEA:54959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + OPC-6 <=> AMP + diphosphate + OPC-6-CoA
RHEA:10794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2 => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+)
REACT:R-HSA-888614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO2 dioxygenates L-Trp to NFK (Homo sapiens)
GO:0140111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[choline trimethylamine-lyase]-activating enzyme activity
REACT:R-DRE-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Danio rerio)
REACT:R-GGA-8849094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RASA1 (Gallus gallus)
RHEA:59864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoate + ATP + L-glutamine = (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)
REACT:R-XTR-5229273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCN2:2,5DHBA binds Fe3+ (Xenopus tropicalis)
REACT:R-SSC-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Sus scrofa)
RHEA:49433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + lithocholoyl-CoA => choloyl-CoA + lithocholate
REACT:R-SSC-8956026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL9:RBX1 ubiquitinates BIRC5 (Sus scrofa)
RHEA:37234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alaninamide <=> L-alanine + NH4(+)
REACT:R-BTA-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Bos taurus)
RHEA:70356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-carboxybiuret + H(+) => biuret + CO2
RHEA:26461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylnitronate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + nitrite
RHEA:41714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycerol 3-phosphate + choline + H(+) => a 2-acyl-sn-glycero-3-phosphocholine + H2O
GO:0140703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP binding
GO:0140703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3' cyclic-GMP-AMP binding
GO:0140703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cyclic GMP-AMP binding
GO:0140703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cyclic GAMP binding
GO:0140703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGMP-AMP binding
REACT:R-BTA-5218640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates p-Y397-PTK2 (Bos taurus)
REACT:R-CFA-917987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFRC dimer binds 2xholoTF (Canis familiaris)
REACT:R-HSA-168306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concerted hemagglutinin pore formation (Homo sapiens)
GO:0140096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalytic activity, acting on a protein
RHEA:60672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + nerol = H(+) + NADH + neral
REACT:R-DRE-5689111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 autoubiquitinates (Danio rerio)
REACT:R-DRE-373734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin interacts with Podocin (Danio rerio)
RHEA:40725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoate + CoA + H(+) => (9E)-octadecenoyl-CoA + H2O
REACT:R-HSA-9684238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E and N are recruited to the M lattice (Homo sapiens)
REACT:R-DDI-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Dictyostelium discoideum)
RHEA:30030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + H(+) + NADH <=> glycerol + NAD(+)
GO:0046857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
GO:0046857	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0046857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
REACT:R-CFA-6804879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates TP53 (Canis familiaris)
REACT:R-GGA-5633256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5:atRA translocates from cytosol to nucleoplasm (Gallus gallus)
RHEA:39379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)
RHEA:52878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate
REACT:R-DME-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)
RHEA:31955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:48368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
REACT:R-HSA-9698021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11:p-STAT5 binds BCL2L1 promoter (Homo sapiens)
RHEA:48564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin
REACT:R-GGA-873951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1:HSP90 binds inactive NLRP3 (Gallus gallus)
REACT:R-BTA-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Bos taurus)
REACT:R-MMU-70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate + H2O => 4-imidazolone-5-propionate (Mus musculus)
RHEA:35267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol(in) = ethanol(out)
GO:0050498	skos:prefLabel	"With 2-oxoglutarate as one donor, and the other dehydrogenated"
GO:0050498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With 2-oxoglutarate as one donor, and the other dehydrogenated"
GO:0050498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated
REACT:R-DRE-8865320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX1 (Danio rerio)
RHEA:20068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineate + 2-oxoglutarate + O2 <=> 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate
REACT:R-HSA-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Homo sapiens)
REACT:R-BTA-2046285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The keratan chain can be capped by N-acetylneuraminic acid (Bos taurus)
REACT:R-RNO-8875902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC45A3 transports Glc from extracellular region to cytosol (Rattus norvegicus)
RHEA:37021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + AH2 + NH4(+) => A + D-serine + H2O
REACT:R-BTA-8987105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Bos taurus)
RHEA:55633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)
GO:0070037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (Homo sapiens)
GO:0070037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (pseudouridine) methyltransferase activity
REACT:R-XTR-163748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Xenopus tropicalis)
REACT:R-CFA-9018877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Canis familiaris)
EC:2.8.2.21	skos:prefLabel	"keratan sulfotransferase"
EC:2.8.2.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"keratan sulfotransferase"
REACT:R-HSA-9018907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Homo sapiens)
REACT:R-HSA-450490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein Kinase B/Akt phosphorylates BRF1 (Homo sapiens)
RHEA:28457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-fructosyl)-L-lysine(in) <=> N(6)-(D-fructosyl)-L-lysine(out)
REACT:R-HSA-449803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 dimer binds IL10RA:JAK1 (Homo sapiens)
REACT:R-GGA-9716258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimethyl fumarate modifies Cys191 in GSDMD (Gallus gallus)
RHEA:67709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate
RHEA:14100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-aspartate <=> L-phenylalanine + oxaloacetate
REACT:R-XTR-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Xenopus tropicalis)
RHEA:31052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-beta-leucine + H2O + NAD(+) => 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)
RHEA:29384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + H2O => 2'-deoxyinosine + phosphate
RHEA:41761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) => CMP + ganglioside GD3 (d18:1(4E)) + H(+)
RHEA:65533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-1-ol + hexanoyl-CoA => 2-methylbutyl hexanoate + CoA
RHEA:51113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-MMU-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Mus musculus)
REACT:R-DME-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Drosophila melanogaster)
REACT:R-BTA-6804741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 forms homo- or heterodimers (Bos taurus)
REACT:R-HSA-193054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cholesterol to 22beta-hydroxycholesterol (Homo sapiens)
REACT:R-DRE-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Danio rerio)
REACT:R-MMU-8866308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL translocates from RER membrane to SER lumen (Mus musculus)
GO:0052883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine ammonia-lyase"
GO:0052883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine = (E)-4-coumarate + NH4(+)
GO:0052883	skos:altLabel	"L-tyrosine ammonia-lyase"
GO:0052883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-tyrosine ammonia-lyase activity
GO:0052883	skos:altLabel	"TAL"
GO:0052883	skos:prefLabel	"tyrosine ammonia-lyase"
GO:0052883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine ammonia-lyase activity
GO:0052883	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	TAL activity
GO:0052883	skos:altLabel	"tyrase"
GO:0052883	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tyrase activity
REACT:R-SSC-6788867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3K phosphorylates ketosamines (Sus scrofa)
RHEA:37764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:70818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-histidine(in) + L-ornithine(out) <=> H(+)(out) + L-histidine(out) + L-ornithine(in)
RHEA:28521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
RHEA:31494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasaponin III + UDP-beta-L-rhamnose <=> H(+) + soyasaponin I + UDP
REACT:R-MMU-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Mus musculus)
REACT:R-SSC-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Sus scrofa)
REACT:R-CFA-8948063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Canis familiaris)
REACT:R-DRE-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Danio rerio)
REACT:R-MMU-170672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Mus musculus)
RHEA:63388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heme a synthase"
RHEA:63388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a
RHEA:63388	skos:prefLabel	"heme a synthase"
REACT:R-BTA-1250315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB4 homodimers (Bos taurus)
REACT:R-DRE-194689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Danio rerio)
REACT:R-SSC-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Sus scrofa)
GO:0052639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity
GO:0052639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylic acid glucosyltransferase (ester-forming) activity
GO:0052639	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	salicylic acid glucosyltransferase activity
GO:0052639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:SA glucosyltransferase (ester-forming) activity
GO:0052639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity
GO:0052639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP:glucose:salicylate glucosyltransferase (ester-forming) activity
REACT:R-HSA-6781905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZRANB1 binds APC (Homo sapiens)
REACT:R-DRE-205306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP1 and KIT (Danio rerio)
RHEA:48373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)
RHEA:34119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA
RHEA:34119	skos:prefLabel	"3,5,7-trioxododecanoyl-CoA synthase"
RHEA:34119	skos:altLabel	"olivetol synthase"
RHEA:34119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,5,7-trioxododecanoyl-CoA synthase"
GO:0140431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-(abasic site) binding
GO:0140431	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA-(apurinic site) binding
GO:0140431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-(apurinic site/apyrimidinic site) binding
GO:0140431	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA-(apyrimidinic site) binding
GO:0140431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA AP site binding
REACT:R-DME-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Drosophila melanogaster)
REACT:R-RNO-5634221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 binds TRAF2 within TNFR1 signaling complex (Rattus norvegicus)
RHEA:17584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O <=> an L-alpha-amino acid + CO2 + NH4(+)
RHEA:50512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]
RHEA:22971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanal + CoA + NAD(+) <=> butanoyl-CoA + H(+) + NADH
REACT:R-HSA-3857328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPS6KA1/2/3 phosphorylates CEBPB on S321 (Homo sapiens)
REACT:R-RNO-1112708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-Y759-IL6ST (Rattus norvegicus)
REACT:R-DRE-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Danio rerio)
REACT:R-HSA-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Homo sapiens)
RHEA:61563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-8987043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22RA1 binds JAK1 (Canis familiaris)
REACT:R-BTA-5669024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD70 binds CD27 (Bos taurus)
RHEA:50048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholate(in) + H2O = ADP + cholate(out) + H(+) + phosphate
GO:0004653	skos:prefLabel	"polypeptide N-acetylgalactosaminyltransferase"
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polypeptide N-acetylgalactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polypeptide-N-acetylgalactosamine transferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoprotein acetylgalactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polypeptide N-acetylgalactosaminyltransferase"
GO:0004653	skos:altLabel	"protein-UDP acetylgalactosaminyltransferase"
GO:0004653	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-UDP acetylgalactosaminyltransferase activity
REACT:R-DRE-176664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + PAPS => estrone 3-sulfate + PAP (Danio rerio)
REACT:R-SSC-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Sus scrofa)
REACT:R-DME-211206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of DFF to the nucleus (Drosophila melanogaster)
REACT:R-SSC-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Sus scrofa)
REACT:R-MMU-9626816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds p-S345-NCF1 (Mus musculus)
RHEA:67124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxide + L-cysteinyl-[protein] = an alcohol + S-hydroxy-L-cysteinyl-[protein]
RHEA:64103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + TAN-1612
REACT:R-DRE-3828025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP14 (Danio rerio)
RHEA:57943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + H(+) + H2O2 <=> CO2 + 2 H2O + harderoheme III
REACT:R-GGA-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Gallus gallus)
RHEA:53096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine
RHEA:67632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] = a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:67632	skos:prefLabel	"ferredoxin--quinone oxidoreductase (H(+)-translocating)"
RHEA:67632	skos:altLabel	"NDH11 complex"
RHEA:67632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin--quinone oxidoreductase (H(+)-translocating)"
RHEA:67632	skos:altLabel	"NDH-1L complex"
RHEA:67632	skos:altLabel	"NDH12 complex"
RHEA:67632	skos:altLabel	"NDH-1L' complex"
REACT:R-HSA-8956586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)
REACT:R-XTR-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Xenopus tropicalis)
GO:0042277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide binding
REACT:R-DRE-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Danio rerio)
RHEA:62503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-arginyl-AMP <=> AMP + H(+) + L-arginyl-[peptidyl-carrier protein]
RHEA:25642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4S)-menthone + NADP(+) => (R)-pulegone + H(+) + NADPH
RHEA:37206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Homo sapiens)
REACT:R-BTA-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Bos taurus)
REACT:R-CFA-8853792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET tyrosine phosphorylation (Canis familiaris)
RHEA:29326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + succinate(out) <=> fumarate(out) + succinate(in)
REACT:R-HSA-163809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
GO:0140010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate transmembrane transporter activity
RHEA:25558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + stemod-13(17)-ene => 9alpha-copalyl diphosphate
REACT:R-MMU-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Mus musculus)
REACT:R-CFA-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Canis familiaris)
REACT:R-RNO-9708536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMOX1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)
EC:1.6.3.5	skos:altLabel	"alpha-NAD(P)H oxidase/anomerase"
EC:1.6.3.5	skos:prefLabel	"renalase"
EC:1.6.3.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"renalase"
REACT:R-RNO-5684865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB dimer,C translocate from multivesicle body to lamellar body (Rattus norvegicus)
REACT:R-HSA-5602966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective FMO3 does not N-oxidise TMA (Homo sapiens)
REACT:R-CFA-4420128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates SHB (Canis familiaris)
REACT:R-RNO-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Rattus norvegicus)
REACT:R-BTA-2029458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV1 to p-6Y-SYK (Bos taurus)
GO:0008084	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	imaginal disc growth factor
GO:0008084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imaginal disc growth factor receptor binding
REACT:R-GGA-353500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear focus formation by interaction of chSNM1A with PIAS1 upon DNA lesion (Gallus gallus)
REACT:R-DRE-1433454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GAB2 by SFKs (Danio rerio)
RHEA:17860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate
RHEA:69260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate
REACT:R-RNO-6787533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Rattus norvegicus)
REACT:R-DRE-444171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR2 binds carboxylates (Danio rerio)
RHEA:30777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NH4(+) + pyridoxal => H2O + O2 + pyridoxamine
RHEA:15161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)
REACT:R-DDI-77078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Dictyostelium discoideum)
RHEA:25548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"levopimaradiene synthase"
RHEA:25548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate
RHEA:25548	skos:prefLabel	"levopimaradiene synthase"
REACT:R-CEL-750993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (q) reassociates with G beta:gamma (Caenorhabditis elegans)
RHEA:24727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-demethylindolmycin + S-adenosyl-L-methionine => H(+) + indolmycin + S-adenosyl-L-homocysteine
REACT:R-MMU-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
GO:0044535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-long-chain acyl-CoA oxidase activity
GO:0044535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very long chain fatty-acyl-CoA oxidase activity
GO:0044535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLC fatty-acyl-CoA oxidase activity
GO:0044535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very-long-chain fatty acyl-CoA oxidase activity
RHEA:72517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + glutarate(out) => (R)-carnitine(out) + glutarate(in)
REACT:R-SPO-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Schizosaccharomyces pombe)
REACT:R-HSA-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Homo sapiens)
RHEA:30809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(1)-piperideine-2-carboxylate + H(+) + NADH => L-pipecolate + NAD(+)
RHEA:46581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 => 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:25248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-lactoylglutathione + H2O <=> (R)-lactate + glutathione + H(+)
REACT:R-MMU-6791235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds AURKA (Mus musculus)
REACT:R-DME-3900194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates DDX5 with SUMO2 (Drosophila melanogaster)
GO:0031824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1E serotonin receptor binding
GO:0031824	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1E serotonin receptor ligand
GO:0031824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 1E receptor binding
GO:0004175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endopeptidase activity
GO:0004175	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proteasome endopeptidase activity
GO:0004175	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	proteinase
GO:0004175	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endoprotease activity
GO:0004175	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	elastase activity
REACT:R-DRE-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Danio rerio)
RHEA:45888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-MMU-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Mus musculus)
RHEA:65844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + phosphate(in) = ADP(in) + phosphate(out)
REACT:R-BTA-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Bos taurus)
REACT:R-DDI-4085992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DAXX with SUMO1 (Dictyostelium discoideum)
RHEA:39978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminobutanoate + H2O <=> 2-oxobutanoate + NH4(+)
REACT:R-CFA-9610152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Canis familiaris)
RHEA:61973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:62610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-sulfanylglutathione + ubiquinol-10 => glutathione + H(+) + hydrogen sulfide + ubiquinone-10
REACT:R-DRE-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Danio rerio)
REACT:R-DME-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Drosophila melanogaster)
REACT:R-BTA-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Bos taurus)
REACT:R-MMU-6799191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Mus musculus)
RHEA:25935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylquinoline + A + H2O <=> 4-methylquinolin-2(1H)-one + AH2
REACT:R-CFA-8938815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 polyubiquitinates RRAGA (Canis familiaris)
REACT:R-RNO-74742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 (Rattus norvegicus)
REACT:R-SPO-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Schizosaccharomyces pombe)
RHEA:16445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyisoflavanone dehydratase"
RHEA:16445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2,3-dihydrogenistein = genistein + H(+) + H2O
RHEA:16445	skos:prefLabel	"2-hydroxyisoflavanone dehydratase"
RHEA:16445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,4',7-trihydroxyisoflavanone = daidzein + H(+) + H2O
REACT:R-RNO-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Rattus norvegicus)
REACT:R-DDI-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Dictyostelium discoideum)
RHEA:20821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline sulfate + H2O => choline + H(+) + sulfate
RHEA:72501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + prostaglandin E2(in) => 2-oxoglutarate(in) + prostaglandin E2(out)
EC:3.4.21.10	skos:prefLabel	"acrosin"
EC:3.4.21.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acrosin"
RHEA:21532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione + glutathionylspermidine = ADP + H(+) + phosphate + trypanothione
REACT:R-BTA-2454240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-FCERI gamma subunit (Bos taurus)
GO:1901707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leptomycin B binding
GO:0008824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate hydratase activity
GO:0008824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyanate C-N-lyase activity
GO:0008824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyanate hydrolase activity
GO:0008824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanase activity
GO:0008824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamate hydro-lyase activity
GO:0008824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate lyase activity
GO:0008824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyanate aminohydrolase activity
REACT:R-GGA-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Gallus gallus)
REACT:R-HSA-193653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF homodimer binds to p75NTR (Homo sapiens)
REACT:R-BTA-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Bos taurus)
RHEA:70204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyldopaminechrome => 5,6-dihydroxyindole-N-methyl
RHEA:10116	skos:altLabel	"6PGD"
RHEA:10116	skos:altLabel	"6-phosphogluconic dehydrogenase"
RHEA:10116	skos:altLabel	"6-phosphogluconic carboxylase"
RHEA:10116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)"
RHEA:10116	skos:altLabel	"phosphogluconic acid dehydrogenase"
RHEA:10116	skos:prefLabel	"phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)"
RHEA:10116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH
RHEA:71778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(out) + H(+)(out) <=> acetoacetate(in) + H(+)(in)
RHEA:13326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate
REACT:R-MMU-5357432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL binds SRC-1 (Mus musculus)
REACT:R-DRE-5696465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP45 deubiquitinates ERCC1 (Danio rerio)
GO:0070742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2H2 zinc finger domain binding
REACT:R-RNO-8865774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLLs polyglutamylate tubulin (Rattus norvegicus)
REACT:R-SCE-70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Saccharomyces cerevisiae)
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mucopeptide glucohydrolase activity
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-7001
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	globulin G
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysozyme activity
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mucopeptide N-acetylmuramoylhydrolase activity
GO:0003796	skos:altLabel	"muramidase"
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidoglycan N-acetylmuramoylhydrolase activity
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	muramidase activity
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysozyme"
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	globulin G1
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,O-diacetylmuramidase activity
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysozyme g
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-N-acetylmuramidase activity
GO:0003796	skos:prefLabel	"lysozyme"
GO:0003796	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PR1-lysozyme
REACT:R-HSA-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Homo sapiens)
RHEA:69606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP <=> 3',5'-cyclic UMP + diphosphate
RHEA:23615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-alpha-santonin + NAD(+) <=> alpha-santonin + H(+) + NADH
GO:1990948	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	APC-Cdc20 complex inhibitor activity
GO:1990948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin ligase inhibitor activity
GO:1990948	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mitotic anaphase-promoting complex inhibitor activity
REACT:R-GGA-2530453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vitronectin (VTN) binds to C5b:C6:C7 (Gallus gallus)
RHEA:54939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-[ACP] + H(+) + NADH <=> decanoyl-[ACP] + NAD(+)
EC:3.1.30.1	skos:altLabel	"single-stranded-nucleate endonuclease"
EC:3.1.30.1	skos:altLabel	"endonuclease S1"
EC:3.1.30.1	skos:prefLabel	"Aspergillus nuclease S1"
EC:3.1.30.1	skos:altLabel	"deoxyribonuclease S1"
EC:3.1.30.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Aspergillus nuclease S1"
RHEA:55829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:30615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phytoene desaturase (zeta-carotene-forming)"
RHEA:30615	skos:altLabel	"2-step phytoene desaturase"
RHEA:30615	skos:prefLabel	"phytoene desaturase (zeta-carotene-forming)"
RHEA:30615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 2 A = 2 AH2 + all-trans-zeta-carotene
RHEA:16189	skos:altLabel	"4-hydroxyphenylpyruvate hydroxylase"
RHEA:16189	skos:prefLabel	"4-hydroxyphenylpyruvate dioxygenase"
RHEA:16189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylpyruvate dioxygenase"
RHEA:16189	skos:altLabel	"p-hydroxyphenylpyruvate dioxygenase"
RHEA:16189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate
RHEA:16189	skos:altLabel	"p-hydroxyphenylpyruvate oxidase"
REACT:R-SSC-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Sus scrofa)
REACT:R-MMU-1678923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR folding by chaperones GP96 and CNPY3 (Mus musculus)
REACT:R-CFA-913374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits SHIP (Canis familiaris)
REACT:R-DME-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Drosophila melanogaster)
REACT:R-RNO-9650858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Meglitinides bind ABCC8 (Rattus norvegicus)
RHEA:39981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-methylpavine + S-adenosyl-L-homocysteine => (+-)-pavine + S-adenosyl-L-methionine
RHEA:42970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(56) in tRNA + S-adenosyl-L-methionine
RHEA:68333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + H2O => (R)-pantothenate + phosphate
RHEA:43024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteine = 2-aminoprop-2-enoate + a thiol
REACT:R-SSC-73585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Sus scrofa)
REACT:R-XTR-9023627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Xenopus tropicalis)
RHEA:67163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + melleolide F + O2 <=> 6'-chloromelleolide F + FAD + H(+) + 2 H2O
RHEA:14860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetate + ATP + L-lysine <=> ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate
RHEA:41407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-methylpyrrolidine + NADP(+) <=> 2-methyl-1-pyrroline + H(+) + NADPH
RHEA:60682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinate + 2 H(+) + NADPH => (+)-artemisinic aldehyde + H2O + NADP(+)
REACT:R-HSA-9706323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA2 (Homo sapiens)
REACT:R-RNO-5617829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of IFT A complex (Rattus norvegicus)
RHEA:70598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-MMU-83582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Mus musculus)
RHEA:70351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose
REACT:R-PFA-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Plasmodium falciparum)
RHEA:14480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-DRE-5625784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Danio rerio)
RHEA:43409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP
RHEA:72210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 hydrogencarbonate(in) <=> chloride(in) + 2 hydrogencarbonate(out)
REACT:R-BTA-177934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR autophosphorylation (Bos taurus)
RHEA:27702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galacturonate = keto-D-tagaturonate
RHEA:69839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-3928598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of p190RhoGEF to p-FAK (Rattus norvegicus)
RHEA:57184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + methylglyoxal = S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]
RHEA:70632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-GGA-4546386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO1 (Gallus gallus)
REACT:R-DRE-2065550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds Importin beta-1 (Danio rerio)
RHEA:60761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone => CoA + jasmolin II
REACT:R-RNO-6800198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Rattus norvegicus)
REACT:R-MMU-2328037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds integrins (Mus musculus)
REACT:R-HSA-5591040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves Factor Va intermediate form for Factor Va (Homo sapiens)
REACT:R-XTR-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Xenopus tropicalis)
RHEA:25698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-hexahomomethionine = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O
RHEA:27379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP
REACT:R-DME-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
RHEA:50023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)
REACT:R-SSC-8865320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX1 (Sus scrofa)
REACT:R-HSA-9032021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RvT1-4 translocate from cytosol to extracellular region (Homo sapiens)
REACT:R-CEL-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Caenorhabditis elegans)
REACT:R-MMU-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Mus musculus)
REACT:R-XTR-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Xenopus tropicalis)
REACT:R-SSC-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Sus scrofa)
REACT:R-HSA-9656212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF1 mutants (Homo sapiens)
REACT:R-DDI-1247935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)
GO:0061897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans retinal 3,4-desaturase activity
RHEA:29680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(in) => formate(out)
REACT:R-CFA-5651657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)
REACT:R-DRE-5635741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Danio rerio)
REACT:R-SPO-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Schizosaccharomyces pombe)
REACT:R-HSA-981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3 convertases spontaneously dissociate (Homo sapiens)
RHEA:59903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 <=> CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate
REACT:R-HSA-353125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteosome degrades ODC holoenzyme complex (Homo sapiens)
REACT:R-XTR-3095889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC dealkylates RCbl (Xenopus tropicalis)
RHEA:66899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]
RHEA:54276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartyl-[protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate
REACT:R-DDI-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Dictyostelium discoideum)
REACT:R-RNO-5658430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF1 is degraded by the proteasome (Rattus norvegicus)
REACT:R-DME-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Drosophila melanogaster)
REACT:R-HSA-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Homo sapiens)
RHEA:31255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate
RHEA:34981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) => H(+)(in)
REACT:R-BTA-110218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by TDG glycosylase (Bos taurus)
RHEA:34478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate <=> 15-cis-phytoene + 2 diphosphate
REACT:R-CFA-3769391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 binds the beta-catenin:CBY complex (Canis familiaris)
RHEA:71564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminomethyl-dUMP in DNA + acetyl-CoA => 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)
REACT:R-HSA-389954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
REACT:R-SSC-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
RHEA:51976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:1.2.1.44	skos:prefLabel	"cinnamoyl-CoA reductase"
EC:1.2.1.44	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cinnamoyl-CoA reductase"
RHEA:20916	skos:prefLabel	"cysteine lyase"
RHEA:20916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + sulfite = hydrogen sulfide + L-cysteate
RHEA:20916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine lyase"
REACT:R-DDI-9701211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer binds TRPA1 antagonists (Dictyostelium discoideum)
REACT:R-CEL-8932633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Caenorhabditis elegans)
RHEA:24435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate <=> acetate + H(+) + oxalate
REACT:R-XTR-114684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Syntaxin-4 (Xenopus tropicalis)
REACT:R-HSA-1980042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 binds JAG1 (Homo sapiens)
REACT:R-HSA-2972964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter (Homo sapiens)
RHEA:66283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solanidine + UDP-alpha-D-glucose <=> H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP
REACT:R-GGA-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Gallus gallus)
REACT:R-RNO-6801666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates CENPJ (Rattus norvegicus)
RHEA:20428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + ATP + hydrogencarbonate <=> (S)-oxalosuccinate + ADP + H(+) + phosphate
REACT:R-SPO-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Schizosaccharomyces pombe)
REACT:R-GGA-186826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to the active receptor (Gallus gallus)
RHEA:19430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[beta-adrenergic receptor] + ATP => [beta-adrenergic receptor]-phosphate + ADP + H(+)
REACT:R-GGA-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Gallus gallus)
REACT:R-CFA-9661397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)
REACT:R-SSC-937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 (Sus scrofa)
RHEA:41524	skos:altLabel	"THNS"
RHEA:41524	skos:prefLabel	"1,3,6,8-tetrahydroxynaphthalene synthase"
RHEA:41524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + 5 malonyl-CoA = 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol
RHEA:41524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,3,6,8-tetrahydroxynaphthalene synthase"
REACT:R-SPO-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Schizosaccharomyces pombe)
REACT:R-MMU-1369052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid influx (Mus musculus)
REACT:R-MMU-5627275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOPC promotes translocation of CFTR to lysosomes (Mus musculus)
REACT:R-CFA-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Canis familiaris)
RHEA:35624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate + D-glutamine => gamma-D-glutamyl-D-glutamate + NH4(+)
REACT:R-SSC-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
REACT:R-RNO-6805638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A acetylates TP53 (Rattus norvegicus)
REACT:R-DRE-2230983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP1:Hemopexin:heme is endocytosed (Danio rerio)
REACT:R-SPO-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Schizosaccharomyces pombe)
RHEA:51399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin <=> CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin
RHEA:22515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + precorrin-8X <=> hydrogenobyrinate
RHEA:31660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine
REACT:R-DDI-390250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Dictyostelium discoideum)
RHEA:61796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP = AMP + L-tryptophyl-[peptidyl-carrier protein]
REACT:R-RNO-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Rattus norvegicus)
REACT:R-RNO-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Rattus norvegicus)
RHEA:13539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-alpha-D-mannose
RHEA:31954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:37175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-XTR-3858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL recruits RAC (Xenopus tropicalis)
GO:0016206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catecholamine O-methyltransferase activity
GO:0016206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRTOMT transfers Met to DA, forming 3MT (Homo sapiens)
GO:0016206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol O-methyltransferase activity
GO:0016206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	COMT I
GO:0016206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MB-COMT (membrane-bound form of catechol-O-methyltransferase)
GO:0016206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catechol methyltransferase activity
GO:0016206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	COMT II
GO:0016206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:catechol O-methyltransferase activity
GO:0016206	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-COMT (soluble form of catechol-O-methyltransferase)
REACT:R-DDI-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Dictyostelium discoideum)
GO:0052914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16S rRNA (guanine(1207)-N(2))-methyltransferase activity
GO:0052914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	M(2)G1207 methyltransferase activity
RHEA:38276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalyl-CoA => acetyl-CoA + pyruvate
REACT:R-RNO-936986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)
RHEA:47723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + isoguanine <=> NH4(+) + xanthine
REACT:R-DRE-109860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 phosphorylates MAPK3 (Danio rerio)
RHEA:43467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-GGA-8875558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 binds CRK,CRKL (Gallus gallus)
RHEA:27672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + phosphate => 1D-myo-inositol 1-phosphate + H2O
REACT:R-HSA-2309779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer binds PTGS2 inhibitors (Homo sapiens)
REACT:R-DRE-71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Danio rerio)
REACT:R-SCE-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Saccharomyces cerevisiae)
REACT:R-CFA-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)
REACT:R-MMU-5690023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL binds 4Fe-4S (Mus musculus)
RHEA:65473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanoyl-CoA + ethanol => CoA + ethyl 2-methylbutanoate
REACT:R-CFA-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Canis familiaris)
RHEA:28823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-galactonate(in) = H(+)(out) + L-galactonate(out)
RHEA:66765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + folate(in) + H2O => ADP + folate(out) + H(+) + phosphate
RHEA:51405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine + O2 => 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)
RHEA:27878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-UMP + H2O = 3'-UMP + H(+)
REACT:R-BTA-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Bos taurus)
GO:0018793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dibromo-4-hydroxybenzoate decarboxylase activity
RHEA:15751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + phenylglyoxylate => (S)-mandelate + A
REACT:R-BTA-389986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Bos taurus)
REACT:R-SSC-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Sus scrofa)
REACT:R-BTA-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Bos taurus)
REACT:R-DRE-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Danio rerio)
REACT:R-BTA-351987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A6-mediated uptake of taurine and beta-alanine (Bos taurus)
GO:0016855	skos:prefLabel	"Acting on amino acids and derivatives"
GO:0016855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on amino acids and derivatives"
GO:0016855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	racemase and epimerase activity, acting on amino acids and derivatives
GO:0030594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotransmitter receptor activity
RHEA:62336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP = adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)
GO:0031926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal phosphate transmembrane transporter activity
REACT:R-XTR-964811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5AR2 binds anaphylatoxins and thier desArginated derivatives (Xenopus tropicalis)
REACT:R-HSA-9753285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)
REACT:R-XTR-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Xenopus tropicalis)
REACT:R-DME-432371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRY is activated by light and binds to phosphorylated nuclear TIM (Drosophila melanogaster)
REACT:R-BTA-380608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Bos taurus)
REACT:R-CFA-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Canis familiaris)
RHEA:39635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)
RHEA:24623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + octan-1-ol <=> H(+) + NADH + octanal
RHEA:27488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + 2 H(+) + H2O <=> (S)-2-ureidoglycine + CO2 + NH4(+)
REACT:R-DDI-8938300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vanin hydrolyses pantetheine to PanK, 2AET (Dictyostelium discoideum)
RHEA:25366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) <=> H(+) + momilactone A + NADH
RHEA:65365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
RHEA:30586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide <=> 2-demethylmenaquinone-8 + H2O + trimethylamine
GO:0070694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonucleoside 5'-monophosphate N-glycosidase activity
GO:0070694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNPH1 hydrolyses dGMP (Homo sapiens)
GO:0070694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxynucleoside 5'-monophosphate N-glycosidase activity
RHEA:63431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + levoglucosan <=> ADP + D-glucose 6-phosphate + H(+)
RHEA:10168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:10168	skos:prefLabel	"15,16-dihydrobiliverdin:ferredoxin oxidoreductase"
RHEA:10168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"15,16-dihydrobiliverdin:ferredoxin oxidoreductase"
REACT:R-PFA-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)
GO:0102987	skos:altLabel	"oleoyl-CoA 12-desaturase"
GO:0102987	skos:altLabel	"Delta(12) fatty acid desaturase"
GO:0102987	skos:altLabel	"Delta(12)(omega(6))-desaturase"
GO:0102987	skos:altLabel	"Delta(12) desaturase"
GO:0102987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoleic acid delta 12 desaturase activity
GO:0102987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA (9+3)-desaturase"
GO:0102987	skos:altLabel	"oleoyl-CoA Delta(12) desaturase"
GO:0102987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0102987	skos:prefLabel	"acyl-CoA (9+3)-desaturase"
GO:0102987	skos:altLabel	"Delta(12)-fatty-acid desaturase"
GO:0102987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:36921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA
RHEA:29665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + xanthine(out) => H(+)(in) + xanthine(in)
RHEA:28461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin(in) <=> biotin(out)
RHEA:61963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Danio rerio)
RHEA:42154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine
RHEA:46205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Rattus norvegicus)
RHEA:61048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lochnericine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Homo sapiens)
REACT:R-DME-5674132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)
RHEA:39769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0016617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyproline oxidase activity
GO:0016617	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-L-proline:NAD+ oxidoreductase activity
GO:0016617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxy-L-proline oxidase activity
GO:0016617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-oxoproline reductase activity
RHEA:41760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) = CMP + ganglioside GD3 (d18:1(4E)) + H(+)
RHEA:22543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-dehydroadenosine + H2O + O2 <=> 9-riburonosyladenine + H(+) + H2O2
GO:0052751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-mannose hydrolase activity
GO:0052751	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose pyrophosphatase activity
GO:0099186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of postsynapse
REACT:R-CFA-391939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP receptor can bind thromboxane (Canis familiaris)
RHEA:63125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl ethanolamine => ethanolamine + octadecanoate
RHEA:14295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone + H(+) + NADH => D-glucose + NAD(+)
RHEA:31237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-4-hydroxy-2-oxoglutarate + L-glutamate => (4S)-4-hydroxy-L-glutamate + 2-oxoglutarate
RHEA:60516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan = D-tryptophan
RHEA:16180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + retinal <=> 2 H(+) + NADH + retinoate
RHEA:55294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine => pseudouridine(54) in tRNA + S-adenosyl-L-methionine
REACT:R-DDI-9653108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Raf dimer inhibitors bind RAF heterodimers (Dictyostelium discoideum)
REACT:R-DRE-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Danio rerio)
REACT:R-DRE-159773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein S to protein S (Danio rerio)
EC:1.2.3.1	skos:prefLabel	"aldehyde oxidase"
EC:1.2.3.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldehyde oxidase"
EC:1.2.3.1	skos:altLabel	"retinal oxidase"
EC:1.2.3.1	skos:altLabel	"quinoline oxidase"
REACT:R-RNO-193800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Rattus norvegicus)
REACT:R-XTR-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Xenopus tropicalis)
REACT:R-DME-350458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOGAPP190 activates GTP hydrolysis by RHO1:GTP (Drosophila melanogaster)
REACT:R-PFA-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
RHEA:21679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dimethylallyl diphosphate <=> (R)-lavandulyl diphosphate + diphosphate
REACT:R-GGA-1614336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Gallus gallus)
RHEA:71167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(out) + H(+)(in) + Na(+)(out) = glycine(in) + H(+)(out) + Na(+)(in)
REACT:R-HSA-1214188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDM9 trimethylates histone H3 (Homo sapiens)
REACT:R-CFA-9008285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Canis familiaris)
REACT:R-CEL-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Caenorhabditis elegans)
RHEA:57960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + H(+) + NADH + O2 = dimethyl sulfoxide + H2O + NAD(+)
REACT:R-CFA-2730842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K associates with phosphorylated GAB2 (Canis familiaris)
REACT:R-SSC-983266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins bind microtubules (Sus scrofa)
REACT:R-SSC-8985900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Sus scrofa)
REACT:R-RNO-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
REACT:R-MMU-193535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)
RHEA:70601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA
REACT:R-CFA-202241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SLP-76 to Gads (Canis familiaris)
REACT:R-CFA-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Canis familiaris)
REACT:R-DRE-5218850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)
REACT:R-RNO-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Rattus norvegicus)
RHEA:72507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + prostaglandin F2alpha(out) = 2-oxoglutarate(out) + prostaglandin F2alpha(in)
GO:0018588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBT dioxygenase activity
GO:0018588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tri-n-butyltin dioxygenase activity
RHEA:45729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeyl alcohol + NADP(+) => (E)-caffeyl aldehyde + H(+) + NADPH
REACT:R-GGA-397891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:G12/13 (active) dissociate (Gallus gallus)
REACT:R-DRE-191402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of presqualene diphosphate to form squalene (Danio rerio)
REACT:R-XTR-2294600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates condensin II subunit NCAPD3 (Xenopus tropicalis)
RHEA:29757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate(out) => (R)-lipoate(in)
RHEA:20334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[acetyl-CoA carboxylase] => ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]
RHEA:69919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine(out) + 2 Na(+)(out) = inosine(in) + 2 Na(+)(in)
RHEA:63152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-fatty acyl-taurine + H2O = a fatty acid + taurine
REACT:R-DDI-77071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation (Ser5) of RNA pol II CTD (Dictyostelium discoideum)
REACT:R-HSA-5625883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)
REACT:R-XTR-182594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of INK4 family proteins with CDK4/6 (Xenopus tropicalis)
RHEA:11949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-CoA + H2O => 4-hydroxybenzoate + CoA + H(+)
RHEA:27757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylglyoxal <=> (R)-lactate + H(+)
REACT:R-CFA-173512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Canis familiaris)
REACT:R-XTR-9037761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Xenopus tropicalis)
REACT:R-DME-176517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to PREG (Drosophila melanogaster)
REACT:R-DME-72143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lariat Formation and 5'-Splice Site Cleavage (Drosophila melanogaster)
RHEA:59067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylluteothin + S-adenosyl-L-methionine <=> luteothin + S-adenosyl-L-homocysteine
EC:2.8.1.-	skos:prefLabel	"Sulfurtransferases"
EC:2.8.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Sulfurtransferases"
REACT:R-SSC-975311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Sus scrofa)
REACT:R-DDI-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Dictyostelium discoideum)
REACT:R-MMU-451561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO binds polyubiquitinated IRAK1 (Mus musculus)
REACT:R-SSC-2404200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2 binds IGF1R (Sus scrofa)
GO:0033790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylfurfural reductase activity
RHEA:30721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-3-oxobutanoyl-CoA + CoA => acetyl-CoA + propanoyl-CoA
REACT:R-HSA-912724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds B-cell linker protein (Homo sapiens)
REACT:R-RNO-351863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active caspase-8 to the mitochondrial membrane (Rattus norvegicus)
RHEA:41976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) = CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)
GO:0047438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-D-xylonate aldolase activity
GO:0047438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity
GO:0047438	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	2-keto-3-deoxy-L-arabonate aldolase activity
GO:0047438	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-deoxy-D-pentulosonic acid aldolase
GO:0047438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)
GO:0047438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-L-pentonate aldolase activity
GO:0047438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-pentonate aldolase activity
REACT:R-XTR-8944254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVI (Xenopus tropicalis)
REACT:R-HSA-9683653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike protein gets palmitoylated (Homo sapiens)
GO:0050411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agaritine g-glutamyltransferase activity
GO:0050411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agaritine gamma-glutamyltransferase activity
GO:0050411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity
GO:0050411	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity
REACT:R-HSA-9769307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 represses INS gene expression (Homo sapiens)
REACT:R-GGA-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Gallus gallus)
RHEA:41626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + propanoyl-CoA + sulfite => 3-sulfinopropanoyl-CoA + H2O
REACT:R-XTR-158750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Xenopus tropicalis)
RHEA:29833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ni(2+)(out) => Ni(2+)(in)
GO:0103041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate-thioredoxin sulfurtransferase activity
RHEA:62508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
RHEA:25600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate <=> (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin-E2 9-reductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-E2 9-oxoreductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, 15-hydroxy-9-oxoprostaglandin
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	9-ketoprostaglandin reductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin E 9-ketoreductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	9-keto-prostaglandin E(2) reductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGE-9-ketoreductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGE2-9-OR
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGE2 9-oxoreductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGE(2) 9-oxoreductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-E(2) 9-oxoreductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGE2-9-ketoreductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	9-keto-prostaglandin E2 reductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGE(2) 9-ketoreductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin E2-9-oxoreductase activity
GO:0050221	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGE2 9-ketoreductase activity
REACT:R-BTA-2066788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Bos taurus)
GO:0106314	skos:prefLabel	"nitrite reductase [NAD(P)H]"
GO:0106314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 3 NADP(+) + NH4(+) = 5 H(+) + 3 NADPH + nitrite
GO:0106314	skos:altLabel	"nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate))"
GO:0106314	skos:altLabel	"NADPH-nitrite reductase"
GO:0106314	skos:altLabel	"assimilatory nitrite reductase"
GO:0106314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrite reductase [NAD(P)H]"
GO:0106314	skos:altLabel	"NAD(P)H:nitrite oxidoreductase"
GO:0106314	skos:altLabel	"NADH-nitrite oxidoreductase"
GO:0106314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite reductase NADPH activity
GO:0002083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate decaprenyltransferase activity
RHEA:19106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanal + H2O + NAD(+) => 4-aminobutanoate + 2 H(+) + NADH
REACT:R-RNO-9755306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub UBXN7 is degraded by the 26S proteasome (Rattus norvegicus)
GO:0036433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans, poly-cis-undecaprenol kinase activity
GO:0036433	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ditrans,polycis-undecaprenol kinase activity
REACT:R-DDI-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Dictyostelium discoideum)
REACT:R-HSA-167090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)
REACT:R-MMU-2682349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Mus musculus)
REACT:R-RNO-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Rattus norvegicus)
RHEA:31641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + mycinamicin IV + S-adenosyl-L-homocysteine => mycinamicin III + S-adenosyl-L-methionine
RHEA:51644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + H(+) + NADH + O2 = 7-dehydrocholesterol + 2 H2O + NAD(+)
REACT:R-HSA-9610954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCMV Final Envelopment (Homo sapiens)
REACT:R-DME-975389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Drosophila melanogaster)
REACT:R-XTR-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Xenopus tropicalis)
REACT:R-XTR-70577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Xenopus tropicalis)
REACT:R-DME-6782820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates SUDS3 (Drosophila melanogaster)
REACT:R-DRE-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Danio rerio)
REACT:R-BTA-2534365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Slo3 Potassium Transport (Bos taurus)
REACT:R-HSA-6794344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOMER binds SHANK proteins (Homo sapiens)
RHEA:11345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylneuraminate + CTP => a CMP-N-acyl-beta-neuraminate + diphosphate
RHEA:38440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
RHEA:57655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 <=> CMP + ganglioside GM1alpha + H(+)
REACT:R-XTR-9012319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Xenopus tropicalis)
GO:0015401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea active transmembrane transporter activity
GO:0015401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urea:sodium symporter activity
REACT:R-GGA-114263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization  of BAK at the mitochondrial membrane (Gallus gallus)
RHEA:47016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O = [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite
RHEA:19312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate
REACT:R-BTA-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Bos taurus)
RHEA:35678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine + tetradecanoyl-CoA <=> 3-oxohexadecasphinganine + CO2 + CoA
RHEA:43017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-alkyl-L-cysteine => 2-aminoprop-2-enoate + an alkyl thiol
REACT:R-BTA-189384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)
REACT:R-CFA-5696007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF3 ligates CoA-SH to VLCFA (Canis familiaris)
RHEA:26487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-phospho-L-serine + sulfite => L-cysteate + phosphate
REACT:R-BTA-5694109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer hydrolyses TAG to DAG and FA (Bos taurus)
REACT:R-CFA-2559456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)
RHEA:31118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin + H(+) <=> biotinyl-5'-AMP + diphosphate
RHEA:37723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-SSC-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Sus scrofa)
RHEA:37728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
GO:0140033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylation-dependent protein binding
REACT:R-XTR-75090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR1 homodimer to dsRNA duplex (Xenopus tropicalis)
REACT:R-MMU-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Mus musculus)
RHEA:40362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-CFA-5693615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Canis familiaris)
REACT:R-XTR-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Xenopus tropicalis)
REACT:R-DRE-983142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of peptide loading complex (PLC) (Danio rerio)
RHEA:59199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP <=> AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]
REACT:R-SSC-3262512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Sus scrofa)
RHEA:18646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 putrescine => NH4(+) + sym-homospermidine
RHEA:15724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H2O + NAD(+) <=> glyoxylate + H(+) + NADH + NH4(+)
RHEA:44891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)
REACT:R-GGA-2428930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Gallus gallus)
REACT:R-XTR-8953115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds to MGA:MAX (Xenopus tropicalis)
REACT:R-BTA-8983374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Bos taurus)
GO:0033931	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosaminoglycan glycanohydrolase activity
GO:0033931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endogalactosaminidase activity
RHEA:13631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carvone + H(+) + NADPH => (1S,5R)-carveol + NADP(+)
REACT:R-GGA-5694445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH1 binds TFGA and AREG precursors (Gallus gallus)
RHEA:64595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base
GO:0018631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetate hydroxylase activity
RHEA:55963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate + ATP + CoA <=> AMP + diphosphate + gamma-butyrobetainyl-CoA
REACT:R-HSA-933527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)
REACT:R-DRE-195408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Danio rerio)
RHEA:12545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine => 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate
REACT:R-CEL-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Caenorhabditis elegans)
REACT:R-GGA-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Gallus gallus)
GO:0008255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysis-triggering hormone activity
RHEA:57178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => L-arginyl-[protein] + methylglyoxal
REACT:R-XTR-1592316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP1 (Xenopus tropicalis)
RHEA:31369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nitrate + 2 nitric oxide => 2 H(+) + 3 nitrite
RHEA:36052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O => 2 beta-L-arabinofuranose
REACT:R-XTR-5696547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBPL1 is a deubiquitinase (Xenopus tropicalis)
REACT:R-SSC-216045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I binds integrin alpha11beta1 (Sus scrofa)
RHEA:45388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine
REACT:R-SSC-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Sus scrofa)
REACT:R-HSA-9025998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA (Homo sapiens)
REACT:R-SPO-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Schizosaccharomyces pombe)
RHEA:65824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Canis familiaris)
RHEA:24015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol + S-adenosyl-L-methionine <=> (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine
RHEA:46080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetracosenoyl-CoA + H(+) + NADH = NAD(+) + tetracosanoyl-CoA
GO:0008782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylhomocysteine nucleosidase activity
GO:0008782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylhomocysteine nucleosidase activity
GO:0008782	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	S-adenosylhomocysteine hydrolase activity
GO:0008782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity
GO:0008782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-homocysteine homocysteinylribohydrolase activity
GO:0008782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AdoHcy/MTA nucleosidase activity
GO:0008782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-methyladenosine nucleosidase activity
REACT:R-GGA-873918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of JAK1 (Gallus gallus)
REACT:R-DME-1606288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Drosophila melanogaster)
REACT:R-BTA-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)
REACT:R-CFA-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Canis familiaris)
REACT:R-DME-8943279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse GSH (Drosophila melanogaster)
REACT:R-DDI-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Dictyostelium discoideum)
RHEA:67888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)
RHEA:52652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol + S-adenosyl-L-methionine = eburicol + H(+) + S-adenosyl-L-homocysteine
RHEA:31642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycinamicin III + S-adenosyl-L-methionine <=> H(+) + mycinamicin IV + S-adenosyl-L-homocysteine
REACT:R-XTR-5362459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Xenopus tropicalis)
REACT:R-CEL-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Caenorhabditis elegans)
RHEA:26191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP
RHEA:27338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] => 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]
REACT:R-MMU-201685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin is released from the destruction complex (Mus musculus)
RHEA:62636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O
RHEA:62636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipoyl-dependent peroxiredoxin"
RHEA:62636	skos:prefLabel	"lipoyl-dependent peroxiredoxin"
REACT:R-RNO-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Rattus norvegicus)
GO:0102276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity
REACT:R-BTA-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)
REACT:R-SSC-5654587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS phosphorylates PPTN11 (Sus scrofa)
RHEA:30369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)alamin + phosphate => adenosylcob(III)alamin 5'-phosphate + H2O
REACT:R-RNO-212005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2F1 dehydrogenates 3-methylindole (Rattus norvegicus)
RHEA:13083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin + NH4(+) => biotin amide + H2O
REACT:R-DRE-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Danio rerio)
REACT:R-XTR-8987270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Xenopus tropicalis)
REACT:R-HSA-372529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of acetylcholine at the synapse (Homo sapiens)
REACT:R-GGA-74993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Gallus gallus)
RHEA:50765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine
RHEA:39496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)
REACT:R-XTR-167419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex releases GDP (Xenopus tropicalis)
RHEA:63670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH => CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)
REACT:R-DME-8951977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylated RUNX3 binds to BRD2 (Drosophila melanogaster)
REACT:R-RNO-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Rattus norvegicus)
REACT:R-HSA-9605313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine (Homo sapiens)
REACT:R-DDI-5675373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
REACT:R-RNO-2130725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)
RHEA:55763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + a lyso-ornithine lipid <=> an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]
REACT:R-GGA-2132271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H displaces Bb in Cb:Bb complex (Gallus gallus)
REACT:R-XTR-168140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Xenopus tropicalis)
REACT:R-PFA-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Plasmodium falciparum)
RHEA:35477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-5'-oxoaverantin + H(+) + NADH => (1'S,5'S)-5'-hydroxyaverantin + NAD(+)
REACT:R-GGA-202291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Lck (Gallus gallus)
REACT:R-XTR-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Xenopus tropicalis)
RHEA:63752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kermesate + UDP-alpha-D-glucose = carminate + 2 H(+) + UDP
RHEA:38249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + hexadecan-1-ol
REACT:R-GGA-9009371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of AP1 transcriptional activator complexes to CCND1 promoter (Gallus gallus)
REACT:R-SSC-5250209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP binds SLC25A4 (Sus scrofa)
REACT:R-XTR-5357780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Xenopus tropicalis)
REACT:R-XTR-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Xenopus tropicalis)
RHEA:23172	skos:prefLabel	"[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase"
RHEA:23172	skos:altLabel	"hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating)"
RHEA:23172	skos:altLabel	"[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase"
RHEA:23172	skos:altLabel	"AMP-activated protein kinase"
RHEA:23172	skos:altLabel	"beta-hydroxy-beta-methylglutaryl-CoA reductase kinase"
RHEA:23172	skos:altLabel	"3-hydroxy-3-methylglutaryl-CoA reductase kinase"
RHEA:23172	skos:altLabel	"AMPK"
RHEA:23172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]
RHEA:23172	skos:altLabel	"hydroxymethylglutaryl coenzyme A reductase kinase"
RHEA:23172	skos:altLabel	"hydroxymethylglutaryl-CoA reductase kinase"
RHEA:23172	skos:altLabel	"HMG-CoA reductase kinase"
RHEA:23172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase"
RHEA:23172	skos:altLabel	"3-hydroxy-3-methylglutaryl coenzyme A reductase kinase"
RHEA:23172	skos:altLabel	"reductase kinase"
REACT:R-BTA-8956639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds YAP1 (Bos taurus)
RHEA:58333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-en-1-ol + NADP(+) => (E)-non-2-enal + H(+) + NADPH
RHEA:17343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH => 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+)
REACT:R-RNO-9710254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME oligomerizes (Rattus norvegicus)
RHEA:25689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) <=> L-cysteinyl-tRNA(Cys) + phosphate
GO:0102233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonaldehyde redutase activity
REACT:R-SSC-352182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Sus scrofa)
REACT:R-BTA-416559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Rho-GTP by p190RhoGAP (Bos taurus)
REACT:R-BTA-202203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PI3K to plasma membrane (Bos taurus)
REACT:R-MMU-9706287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to ABL2 (Mus musculus)
REACT:R-HSA-5654605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS3 (Homo sapiens)
REACT:R-SSC-977348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHGDH tetramer dehydrogenates 3PG (Sus scrofa)
REACT:R-DME-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Drosophila melanogaster)
EC:3.1.31.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"micrococcal nuclease"
EC:3.1.31.1	skos:altLabel	"micrococcal endonuclease"
EC:3.1.31.1	skos:prefLabel	"micrococcal nuclease"
REACT:R-RNO-416559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Rho-GTP by p190RhoGAP (Rattus norvegicus)
RHEA:56979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol + H2O + 2 oxidized [azurin] <=> 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]
RHEA:62108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DRE-9005980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 binds IL21R:JAK1 (Danio rerio)
RHEA:33608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + ATP + CoA => (9Z)-octadecenoyl-CoA + AMP + diphosphate
REACT:R-BTA-1295634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyacyl-ACP dehydrase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyacyl-acyl carrier protein dehydratase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxydecanoyl-acyl carrier protein dehydratase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxydecanoyl thioester dehydrase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxydecanoyl thiol ester dehydrase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FabA
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxydecanoyl-acyl carrier protein dehydrase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HDDase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydecanoyl-ACP dehydratase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxydecanoate dehydrase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity
GO:0008693	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
REACT:R-XTR-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Xenopus tropicalis)
REACT:R-HSA-9625863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RETN gene expression is stimulated by FOXO1 (Homo sapiens)
RHEA:32249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)
RHEA:63562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin II + L-histidyl-L-leucine => angiotensin I + H2O
RHEA:65277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-165182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of complexed TSC2 by PKB (Drosophila melanogaster)
RHEA:24636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + NAD(+) = H(+) + NADH
REACT:R-GGA-5686642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD52 promotes single strand annealing at resected DNA DSBs (Gallus gallus)
RHEA:68802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + D-glucose => H2O + nigerose
REACT:R-CFA-183002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Canis familiaris)
GO:0097266	skos:prefLabel	"phenylacetyl-CoA 1,2-epoxidase"
GO:0097266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetyl-CoA epoxidase activity
GO:0097266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetyl-CoA 1,2-epoxidase activity
GO:0097266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetyl-CoA 1,2-epoxidase"
GO:0097266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylacetyl-CoA monooxygenase activity
GO:0097266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + phenylacetyl-CoA = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)
GO:0097266	skos:altLabel	"phenylacetyl-CoA monooxygenase"
GO:0097266	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ring 1,2-phenylacetyl-CoA epoxidase activity
RHEA:42339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-5684169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6B binds PTPN6,PTPN11 (Rattus norvegicus)
REACT:R-RNO-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Rattus norvegicus)
REACT:R-MMU-606349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mis18 complex binds the centromere (Mus musculus)
RHEA:35877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA
REACT:R-DRE-177934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR autophosphorylation (Danio rerio)
REACT:R-RNO-372697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binding to p130cas (Rattus norvegicus)
RHEA:55669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol--[retinol-binding protein] + NAD(+) => 11-cis-retinal--[retinol-binding protein] + H(+) + NADH
RHEA:17635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alcohol + D-glucuronate => a beta-D-glucuronoside + H2O
REACT:R-HSA-187211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Splicing of HIV RNA transcript (Homo sapiens)
REACT:R-DDI-5649883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB-mediated DNA strand displacement synthesis (Dictyostelium discoideum)
REACT:R-XTR-2395873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)
REACT:R-DRE-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Danio rerio)
REACT:R-GGA-374787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR neuropeptide receptor binds neuropeptides B and W (Gallus gallus)
REACT:R-DDI-6782069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)
RHEA:31085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + N-acetyl-D-muramate => H2O + N-acetyl-D-muramoyl-L-alanine
REACT:R-CEL-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Caenorhabditis elegans)
REACT:R-DRE-193711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
RHEA:45374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + sphinganine => H2O + N-(9Z-octadecenoyl)-sphinganine
REACT:R-DDI-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)
RHEA:42940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (cytosine(34)-C(5))-methyltransferase"
RHEA:42940	skos:prefLabel	"tRNA (cytosine(34)-C(5))-methyltransferase"
RHEA:42940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-191422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate-5-phosphate is further phosphorylated. (Canis familiaris)
REACT:R-XTR-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Xenopus tropicalis)
RHEA:10294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate => acetyl-CoA + D-glucosamine 6-phosphate
RHEA:38295	skos:prefLabel	"D-2-hydroxyglutarate dehydrogenase"
RHEA:38295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
RHEA:38295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-2-hydroxyglutarate dehydrogenase"
REACT:R-SSC-6806877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Sus scrofa)
RHEA:47823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)
REACT:R-RNO-418170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB1 binds MAPKs, SRC-1 (Rattus norvegicus)
REACT:R-HSA-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Homo sapiens)
RHEA:61178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside] => (E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside
RHEA:66856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 3 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
REACT:R-RNO-159761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Rattus norvegicus)
RHEA:45442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine
RHEA:57408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH
REACT:R-SSC-166271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Sus scrofa)
RHEA:62498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + L-arginyl-AMP => ATP + H(+) + L-arginine
RHEA:66501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)
REACT:R-HSA-434633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 binds inhibiting VAV (Homo sapiens)
RHEA:62744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mevastatin = (S)-2-methylbutanoate + compactin diol lactone + H(+)
REACT:R-RNO-9607301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2 binds SOS1 (Rattus norvegicus)
REACT:R-DME-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Drosophila melanogaster)
REACT:R-MMU-1462005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-defensin alpha 5 is secreted (Mus musculus)
RHEA:40532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-6805276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates TP53 (Mus musculus)
REACT:R-HSA-9635739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)
REACT:R-SSC-6785178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Sus scrofa)
GO:0035236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proctolin receptor activity
REACT:R-GGA-158744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Gallus gallus)
REACT:R-RNO-4755494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Rattus norvegicus)
RHEA:10621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamaldehyde + CoA + NADP(+) => (E)-cinnamoyl-CoA + H(+) + NADPH
RHEA:21954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + progesterone => 5alpha-pregnane-3,20-dione + NADP(+)
REACT:R-GGA-5686301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C100-CKAP4 binds SFTPAs (Gallus gallus)
REACT:R-BTA-9706354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of FLT3 (Bos taurus)
REACT:R-SSC-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Sus scrofa)
REACT:R-HSA-1454928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG4 may mediate cholesterol efflux (Homo sapiens)
GO:0047448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)
GO:0047448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxyglucarate dehydratase activity
GO:0047448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)
GO:0047448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyketoglucarate dehydratase activity
GO:0047448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-keto-4-deoxy-glucarate dehydratase activity
GO:0047448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-4-deoxy-5-ketoglucarate hydro-lyase activity
REACT:R-BTA-8986995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Bos taurus)
RHEA:61382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate => 2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O
REACT:R-GGA-983218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51B:RAD51C binds single-stranded DNA (Gallus gallus)
RHEA:25259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-mannosamine 6-phosphate => N-acetyl-D-glucosamine 6-phosphate
RHEA:70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine(in) + L-glutamate(out) => L-cystine(out) + L-glutamate(in)
RHEA:66485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxygypsogenate + UDP-alpha-D-glucose => 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP
REACT:R-CEL-166220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion diffuses laterally to UCP (Caenorhabditis elegans)
REACT:R-DME-1678660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan sulfate chain(3) (Drosophila melanogaster)
RHEA:30987	skos:prefLabel	"protostadienol synthase"
RHEA:30987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = (17Z)-protosta-17(20),24-dien-3beta-ol
RHEA:30987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protostadienol synthase"
RHEA:63090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine
REACT:R-SPO-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Schizosaccharomyces pombe)
REACT:R-CFA-158860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates NHABP (Canis familiaris)
REACT:R-SSC-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Sus scrofa)
REACT:R-SSC-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Sus scrofa)
RHEA:14760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate
REACT:R-DRE-2395364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP4 binds TGF-Beta-1 (Danio rerio)
GO:0035035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase binding
GO:0035035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase binding
REACT:R-DRE-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)
RHEA:13062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + S-sulfanylglutathione => glutathione S,S-dioxide + H(+)
REACT:R-BTA-3000383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I, HDAC7 SUMOylate PML with SUMO1 (Bos taurus)
REACT:R-HSA-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Homo sapiens)
REACT:R-SPO-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Schizosaccharomyces pombe)
REACT:R-BTA-6805109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates TP53 (Bos taurus)
REACT:R-DRE-73932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resynthesis of excised residue by POLB (Danio rerio)
REACT:R-MMU-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Mus musculus)
REACT:R-HSA-8956026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL9:RBX1 ubiquitinates BIRC5 (Homo sapiens)
REACT:R-HSA-1250220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of ERBB4 (Homo sapiens)
REACT:R-DRE-212222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 recruits DNA methyltransferases (Danio rerio)
REACT:R-DME-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Drosophila melanogaster)
REACT:R-DRE-5649664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves FapyG from damaged DNA (Danio rerio)
REACT:R-HSA-164506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gap repair completes provirus integration (Homo sapiens)
REACT:R-HSA-5685011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR activation at DNA DSBs (Homo sapiens)
RHEA:34786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH
GO:0019770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgG receptor activity
REACT:R-GGA-450222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Gallus gallus)
RHEA:33911	skos:prefLabel	"N-alkylglycine oxidase"
RHEA:33911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-alkylglycine oxidase"
RHEA:33911	skos:altLabel	"N-carboxymethylalkylamine:oxygen oxidoreductase (decarboxymethylating)"
RHEA:33911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-alkylglycine + H2O + O2 = an alkylamine + glyoxylate + H2O2
REACT:R-DRE-983161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Danio rerio)
RHEA:57721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 4 H(+)(in) + H2O => ADP + 5 H(+)(out) + phosphate
RHEA:34979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) = H(+)(out)
RHEA:25326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + phosphocholine + S-adenosyl-L-homocysteine
REACT:R-HSA-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Homo sapiens)
RHEA:59103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diglucosyl-enterobactin + UDP-alpha-D-glucose <=> H(+) + triglucosyl-enterobactin + UDP
RHEA:21113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose
REACT:R-DRE-5675433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP5 dephosphorylates RAF1 S338 (Danio rerio)
REACT:R-XTR-983146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Xenopus tropicalis)
REACT:R-SSC-5624126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome bind ciliary cargo (Sus scrofa)
REACT:R-SSC-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Sus scrofa)
GO:0050439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutaric-glyoxylic carboligase activity
GO:0050439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity
GO:0050439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)
GO:0050439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-oxoadipate synthase activity
GO:0050439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-3-oxoadipate synthetase activity
GO:0050439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxoglutarate: glyoxylate carboligase activity
GO:0050439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxoglutarate:glyoxylate carboligase activity
REACT:R-RNO-1234177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
REACT:R-GGA-158137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Gallus gallus)
RHEA:46671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone + H(+) + NADPH <=> 5beta-dihydrodeoxycorticosterone + NADP(+)
RHEA:59460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + NADP(+) = H(+) + hexadecanal + NADPH
REACT:R-SSC-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Sus scrofa)
RHEA:41939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP
RHEA:48641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) => 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH
RHEA:16879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + hypotaurine => 3-sulfino-L-alanine + H(+)
RHEA:64541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base
REACT:R-SPO-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)
RHEA:28875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-tyrosine(in) = H(+)(out) + L-tyrosine(out)
REACT:R-HSA-8866856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate CFTR F508del (Homo sapiens)
REACT:R-SSC-442387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP8 mediates zinc influx into cells (Sus scrofa)
REACT:R-DDI-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)
REACT:R-RNO-110350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of TDG glycosylase by APEX1 at the AP site (Rattus norvegicus)
RHEA:18595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanal + phosphoethanolamine => sphinganine 1-phosphate
REACT:R-GGA-5666169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Gallus gallus)
REACT:R-DRE-741386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 induces K63-linked ubiquitination of NEMO (Danio rerio)
REACT:R-CFA-193997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B1 oxidises 11DCORT (Canis familiaris)
REACT:R-RNO-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Rattus norvegicus)
REACT:R-HSA-112435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin BC complex (Homo sapiens)
REACT:R-RNO-175983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfer CH3 from AdoMet to 3,4DHBNZ (Rattus norvegicus)
RHEA:52803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid
RHEA:51137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate
REACT:R-HSA-204813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb14 (Homo sapiens)
GO:0019957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-C chemokine binding
RHEA:25235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-neuraminate => N-acetyl-alpha-neuraminate
REACT:R-HSA-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Homo sapiens)
RHEA:28411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH
REACT:R-CFA-8857583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by PTK6 (Canis familiaris)
RHEA:65216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-CoA + H2O = 3-oxododecanoate + CoA + H(+)
RHEA:14154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine => 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP
REACT:R-HSA-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Homo sapiens)
REACT:R-XTR-6813740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDE1 hydrolyzes GroPIns (Xenopus tropicalis)
REACT:R-XTR-71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Xenopus tropicalis)
REACT:R-CFA-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)
REACT:R-DDI-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)
REACT:R-CFA-9644869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54-PDE4B hydrolyses cAMP (Canis familiaris)
RHEA:44353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide C + H(+) + phosphate
RHEA:27281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH
REACT:R-DME-68940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdt1 is displaced from the pre-replicative complex. (Drosophila melanogaster)
REACT:R-DRE-9638076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from small HA fragments (Danio rerio)
RHEA:28655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione S,S-dioxide + H2O = glutathione + H(+) + sulfite
REACT:R-DME-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Drosophila melanogaster)
REACT:R-XTR-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Xenopus tropicalis)
REACT:R-DME-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Drosophila melanogaster)
RHEA:31136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate => 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate
REACT:R-CFA-9710106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE cleaves GSDMD (Canis familiaris)
RHEA:14811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anisole + H(+) + S-adenosyl-L-homocysteine => phenol + S-adenosyl-L-methionine
RHEA:44695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-acylhexadecasphinganine
REACT:R-BTA-936380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PIN1 with p-IRF3 (Bos taurus)
REACT:R-CEL-1181149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Caenorhabditis elegans)
GO:0102800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity
REACT:R-GGA-2530584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREM (CREMP) binds to surface-bound C3b or C4b (Gallus gallus)
RHEA:69633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-DDI-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Dictyostelium discoideum)
REACT:R-HSA-8983078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Homo sapiens)
REACT:R-CEL-114552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate G12/13 (Caenorhabditis elegans)
REACT:R-MMU-190408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2b (Mus musculus)
REACT:R-MMU-5610752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3R translocates to the nucleus (Mus musculus)
REACT:R-HSA-205306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP1 and KIT (Homo sapiens)
RHEA:33351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + sphinganine = CoA + H(+) + N-hexacosanoylsphinganine
REACT:R-RNO-5624126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome bind ciliary cargo (Rattus norvegicus)
RHEA:45474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O
REACT:R-PFA-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Plasmodium falciparum)
RHEA:47162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-4-methylzymosterol + CO2 + NADH => 4beta-methylzymosterol-4alpha-carboxylate + NAD(+)
REACT:R-HSA-351987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A6-mediated uptake of taurine and beta-alanine (Homo sapiens)
REACT:R-MMU-6814187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVL:PPL heterodimer binds the inner surface of the plasma membrane (Mus musculus)
REACT:R-XTR-9648114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 recruits NUDC to mitotic spindle (Xenopus tropicalis)
GO:0102097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity
RHEA:40638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate
REACT:R-BTA-8849055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARHGAP35 (Bos taurus)
REACT:R-XTR-1475025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Xenopus tropicalis)
RHEA:30227	skos:prefLabel	"dimethyl sulfide:cytochrome c2 reductase"
RHEA:30227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethyl sulfide:cytochrome c2 reductase"
RHEA:30227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O = dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)
RHEA:29653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine(out) + L-arginine(in) => agmatine(in) + L-arginine(out)
REACT:R-HSA-445088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHL1 interacts with beta1 integrins (Homo sapiens)
RHEA:59293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O => D-galactose + N-octadecanoylsphing-4-enine
REACT:R-SSC-9617996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Sus scrofa)
REACT:R-RNO-165708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated 4EBP1 from eIF4E (Rattus norvegicus)
RHEA:58858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeraniol + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)
RHEA:21110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutanal + CO2 => (S)-3-methyl-2-oxopentanoate + H(+)
REACT:R-DRE-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Danio rerio)
REACT:R-GGA-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
REACT:R-RNO-2514831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP14 (Rattus norvegicus)
RHEA:63439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)
RHEA:13383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + acetyl-CoA => acetate + an acyl-CoA
RHEA:53550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(12)-prostaglandin J2 => prostaglandin J2
REACT:R-SSC-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Sus scrofa)
RHEA:34497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2
REACT:R-CEL-6784224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Caenorhabditis elegans)
REACT:R-SSC-909730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of INFAR1 by TYK2 (Sus scrofa)
RHEA:70335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-L-lyxonolactone + H2O = 2-carboxy-L-lyxonate + H(+)
REACT:R-DME-3780997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG2:GYS2 (Drosophila melanogaster)
RHEA:22439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate
REACT:R-RNO-8876889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)
REACT:R-HSA-9021050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSBP1 oligomer binds ESRs (Homo sapiens)
RHEA:53071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxyestrone + UDP-alpha-D-glucuronate <=> 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-HSA-158447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)
RHEA:12917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha(S)-strictosidine beta-glucosidase"
RHEA:12917	skos:altLabel	"strictosidine beta-glucosidase"
RHEA:12917	skos:prefLabel	"3alpha(S)-strictosidine beta-glucosidase"
RHEA:12917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone
RHEA:72945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + pyruvate(in) => 2 Na(+)(out) + pyruvate(out)
GO:0050011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	itaconyl-CoA hydratase activity
GO:0050011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	itaconyl coenzyme A hydratase activity
GO:0050011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)
GO:0050011	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citramalyl-CoA hydro-lyase activity
REACT:R-CFA-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Canis familiaris)
REACT:R-RNO-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Rattus norvegicus)
RHEA:16595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine
RHEA:71102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) <=> androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)
REACT:R-RNO-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Rattus norvegicus)
REACT:R-MMU-183055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to EGFR (Mus musculus)
RHEA:45041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + hydroxylamine => 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl
REACT:R-RNO-9661625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FVIII is secreted (Rattus norvegicus)
REACT:R-XTR-3245898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds correnoids in the circulation (Xenopus tropicalis)
REACT:R-DRE-5654659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)
RHEA:58988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H2O + O2 = (E)-4-hydroxynon-2-enoate + H(+) + H2O2
REACT:R-XTR-2453863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRA6 transports atROL from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-DRE-2213240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of disulphide bonds in MHC II antigens (Danio rerio)
REACT:R-SSC-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Sus scrofa)
RHEA:58694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV
REACT:R-DME-5653936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Ragulator complex (Drosophila melanogaster)
REACT:R-CFA-5672304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Canis familiaris)
RHEA:58675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate <=> aldehydo-D-glucuronate
REACT:R-MMU-5693578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDP1 and TDP2 process unligatable DSB ends (Mus musculus)
RHEA:25180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + CoA + NAD(+) <=> 3-methylbutanoyl-CoA + CO2 + NADH
REACT:R-SSC-201423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI complexes with the Smad complex, suppressing BMP2 signalling (Sus scrofa)
RHEA:65225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol
REACT:R-GGA-391153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds GRB2-1 (Gallus gallus)
RHEA:29316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + H2O => D-galactose + phosphate
REACT:R-BTA-6805205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR35 binds kynurenic acid (Bos taurus)
GO:0008777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-N-acetyl-L-ornithine amidohydrolase activity
GO:0008777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N-acetylornithinase activity
GO:0008777	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2-acetyl-L-ornithine amidohydrolase activity
GO:0008777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylornithine deacetylase activity
GO:0008777	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetylornithinase activity
REACT:R-HSA-8950766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27RA dimerizes (Homo sapiens)
REACT:R-SSC-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)
REACT:R-DRE-216043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II binds integrin alpha10beta1 (Danio rerio)
REACT:R-BTA-140664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)
RHEA:65137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-HSA-8874200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)
GO:0050195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-ribose-5-phosphate 1-phosphotransferase activity
GO:0050195	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribokinase (phosphorylating)
GO:0050195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribokinase activity
REACT:R-MMU-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
GO:0015375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine:sodium symporter activity
GO:0080116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronoxylan glucuronosyltransferase activity
REACT:R-CFA-9027624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DHA to 7-HDHA (Canis familiaris)
RHEA:18816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate
REACT:R-HSA-9707504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 oxidises ferrohemoglobin to MetHb (Homo sapiens)
GO:1990081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine receptor activity
REACT:R-RNO-2022063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Rattus norvegicus)
REACT:R-RNO-912685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBP43 binds IFNAR2 and prevents JAK1 interaction (Rattus norvegicus)
RHEA:70041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:36048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-glyceraldehyde + H2O => (R)-glycerate + AH2 + H(+)
REACT:R-DRE-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Danio rerio)
RHEA:49396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
GO:0008201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparin binding
GO:0008201	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparan sulfate binding
REACT:R-SSC-9617370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-antagonists bind ADRA1A,B,D (Sus scrofa)
RHEA:38039	skos:altLabel	"acyl-lipid omega-13 desaturase"
RHEA:38039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:38039	skos:prefLabel	"acyl-lipid omega-(9-4) desaturase"
RHEA:38039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid omega-(9-4) desaturase"
RHEA:38039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:38039	skos:altLabel	"acyl-lipid 7-desaturase"
RHEA:46440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 = A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O
RHEA:46440	skos:prefLabel	"linoleoyl-lipid Delta(9) conjugase"
RHEA:46440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linoleoyl-lipid Delta(9) conjugase"
RHEA:33561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycerol 3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate
RHEA:45236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]
REACT:R-DDI-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Dictyostelium discoideum)
REACT:R-DME-398184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG activation by G alpha 12/13 (Drosophila melanogaster)
GO:0004765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	shikimate kinase (phosphorylating)
GO:0004765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:shikimate 3-phosphotransferase activity
GO:0004765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	shikimate kinase II
GO:0004765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	shikimate kinase activity
RHEA:72705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose(out) + UMP(in) => UDP-alpha-D-galactose(in) + UMP(out)
REACT:R-DME-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Drosophila melanogaster)
RHEA:71574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(L-seryl)-dTMP in DNA + H(+) <=> 5-aminoethoxy-methyl-dUMP in DNA + CO2
REACT:R-SSC-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Sus scrofa)
RHEA:49061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain alkane + FMNH2 + O2 => a long chain fatty alcohol + FMN + H(+) + H2O
RHEA:59036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DDI-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Dictyostelium discoideum)
REACT:R-RNO-9638075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from DS (Rattus norvegicus)
REACT:R-CEL-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Caenorhabditis elegans)
REACT:R-GGA-3341296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX7,8 catalyze peroxidation of P4HB (PDI) (Gallus gallus)
REACT:R-HSA-9727908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PSMC6 (Homo sapiens)
REACT:R-DRE-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Danio rerio)
REACT:R-HSA-9665009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR (Homo sapiens)
REACT:R-CFA-182993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL) (Canis familiaris)
REACT:R-CEL-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Caenorhabditis elegans)
RHEA:44623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine
REACT:R-DME-350408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PK binds to VANG at the plasma membrane (Drosophila melanogaster)
REACT:R-CFA-8874082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates PTK2 (Canis familiaris)
REACT:R-BTA-71010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUT isomerises L-MM-CoA to SUCC-CoA (Bos taurus)
RHEA:40272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O2
RHEA:54692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate
RHEA:54692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"labda-7,13-dienyl diphosphate synthase"
RHEA:54692	skos:prefLabel	"labda-7,13-dienyl diphosphate synthase"
REACT:R-RNO-9627056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procaspase 9 forms dimer (Rattus norvegicus)
REACT:R-HSA-5654545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent phosphorylation of overexpressed FGFR1c (Homo sapiens)
REACT:R-MMU-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Mus musculus)
RHEA:36372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hydroxybutanoate + NAD(+) => 2-oxobutanoate + H(+) + NADH
REACT:R-CFA-5649800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Canis familiaris)
REACT:R-XTR-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Xenopus tropicalis)
REACT:R-HSA-2161588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta12-PGJ2 is dehydrated to 15d-PGJ2 (Homo sapiens)
REACT:R-CEL-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Caenorhabditis elegans)
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase"
GO:0004380	skos:altLabel	"fucosylgalactose alpha-N-acetylgalactosaminyltransferase"
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	A-transferase activity
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	blood-group substance alpha-acetyltransferase activity
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fucosylgalactose acetylgalactosaminyltransferase activity
GO:0004380	skos:prefLabel	"glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase"
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	A transferase activity
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histo-blood group A acetylgalactosaminyltransferase activity
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	blood-group substance A-dependent acetylgalactosaminyltransferase activity
GO:0004380	skos:altLabel	"fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase"
GO:0004380	skos:altLabel	"histo-blood group A acetylgalactosaminyltransferase"
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-3-N-acetylgalactosaminyltransferase activity
GO:0004380	skos:altLabel	"histo-blood group A transferase"
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity
GO:0004380	skos:altLabel	"A transferase"
GO:0004380	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histo-blood group A transferase activity
REACT:R-DRE-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Danio rerio)
GO:0018855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity
REACT:R-DRE-4084994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU3 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)
RHEA:60832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine in mRNA + H2O = a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate
RHEA:50223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-demethyl-4-deoxygadusol <=> (R)-demethyl-4-deoxygadusol
RHEA:69333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) => 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-DME-9029566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Drosophila melanogaster)
RHEA:72308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + taurocholate(out) => L-glutamate(out) + taurocholate(in)
RHEA:48936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]
REACT:R-RNO-3323050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNRD2 catalyzes the reduction of TXN2 by NADPH (Rattus norvegicus)
GO:0045544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin 20-oxidase activity
REACT:R-RNO-381135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Rattus norvegicus)
REACT:R-CFA-6781833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)
REACT:R-DDI-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Dictyostelium discoideum)
REACT:R-DDI-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Dictyostelium discoideum)
REACT:R-MMU-9024334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Mus musculus)
REACT:R-SCE-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Saccharomyces cerevisiae)
RHEA:72749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene E4(in) => leukotriene E4(out)
REACT:R-BTA-9708525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1:FBXL17 binds SCF(SKP2) complex (Bos taurus)
REACT:R-SCE-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Saccharomyces cerevisiae)
RHEA:54745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-162729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Xenopus tropicalis)
REACT:R-DRE-193646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF binding to p75NTR inactivates RHOA (Danio rerio)
REACT:R-RNO-446868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)
RHEA:24920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine => 2-aminobut-2-enoate + H2O
RHEA:37624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
GO:0070225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavocytochrome c sulfide dehydrogenase activity
GO:0070225	skos:prefLabel	"sulfide-cytochrome-c reductase (flavocytochrome c)"
GO:0070225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfide-cytochrome-c reductase (flavocytochrome c)"
GO:0070225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphide dehydrogenase activity
GO:0070225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfide dehydrogenase activity
GO:0070225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + hydrogen sulfide = 2 Fe(II)-[cytochrome c] + H(+) + sulfur
REACT:R-RNO-8937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)
REACT:R-DRE-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Danio rerio)
RHEA:40213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanedioyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanedioyl-CoA + NAD(+)
REACT:R-RNO-2684507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2, 4, (3) bind FGF2 (Rattus norvegicus)
REACT:R-CEL-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Caenorhabditis elegans)
RHEA:36204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)
GO:0016933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellularly glycine-gated ion channel activity
GO:0016933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	extracellular-glycine-gated ion channel activity
GO:0016933	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycine receptor
RHEA:40925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
GO:0018694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0018694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-cymene methyl hydroxylase activity
GO:0018694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"p-cymene methyl-monooxygenase"
GO:0018694	skos:prefLabel	"p-cymene methyl-monooxygenase"
GO:0018694	skos:altLabel	"p-cymene methyl hydroxylase"
REACT:R-HSA-937059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
REACT:R-CEL-373750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with Plexin-B1:ErbB2 (Caenorhabditis elegans)
REACT:R-HSA-8942607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Homo sapiens)
RHEA:24342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-acetoin + H(+) + NADH => (R,R)-butane-2,3-diol + NAD(+)
REACT:R-DDI-8943040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF polyubiquitinates monoubiquitinated PCNA (Dictyostelium discoideum)
REACT:R-MMU-5693566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 associates with H4K20Me2 at DNA DSBs (Mus musculus)
REACT:R-BTA-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Bos taurus)
REACT:R-DME-209118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane localised SGG phosphorylates ARR (Drosophila melanogaster)
REACT:R-RNO-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Rattus norvegicus)
REACT:R-SSC-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Sus scrofa)
REACT:R-DDI-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Dictyostelium discoideum)
REACT:R-CEL-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Caenorhabditis elegans)
REACT:R-DME-377640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of SRC (Drosophila melanogaster)
REACT:R-XTR-983422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of COPII coated vesicle (Xenopus tropicalis)
REACT:R-XTR-443402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Xenopus tropicalis)
RHEA:67664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid
RHEA:49309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside nLc4Cer(d18:0) + L-fucose
RHEA:27566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 7 diphosphate
REACT:R-SSC-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)
RHEA:50201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
REACT:R-DDI-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Dictyostelium discoideum)
GO:0016417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-acyltransferase activity
REACT:R-HSA-192704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PB1-F2 (Homo sapiens)
RHEA:70872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-valine(out) + Na(+)(out) => L-glutamine(out) + L-valine(in) + Na(+)(in)
RHEA:16464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + urate(in) <=> ADP + H(+) + phosphate + urate(out)
REACT:R-RNO-209859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decarboxylation of 5-hydroxytryptophan forms serotonin (Rattus norvegicus)
RHEA:24672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + xanthine => H2O + hypoxanthine + NAD(+)
RHEA:48053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + dermatan => n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)
RHEA:59044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammarenediol-II + UDP-alpha-D-glucose = (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP
REACT:R-GGA-2465890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR2 binds collagen type I, II, III, V, X fibrils (Gallus gallus)
REACT:R-SSC-3371467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 deacetylates HSF1 (Sus scrofa)
RHEA:69935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(out) + Na(+)(out) = guanosine(in) + Na(+)(in)
REACT:R-DRE-9029551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Danio rerio)
REACT:R-XTR-192157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)
REACT:R-MMU-9038163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Mus musculus)
RHEA:19259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ketone + H(+) + NADPH => a secondary alcohol + NADP(+)
RHEA:53816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-succinyl-L-serine = L-cysteine + succinate
RHEA:52536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + dGTP = AMP + dGDP + H(+)
RHEA:33824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH => NAD(+) + tetrahydro-4-hydroxyphenylpyruvate
REACT:R-MMU-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Mus musculus)
REACT:R-MMU-3364014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SET1 methyltransferase complex (Mus musculus)
REACT:R-SSC-2187401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)
REACT:R-SSC-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)
RHEA:33438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fecosterol <=> episterol
RHEA:66647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + trichobrasilenol
RHEA:22570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascopyrone P => ascopyrone M
REACT:R-DRE-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Danio rerio)
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP aminohydrolase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylate aminohydrolase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylic deaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylate deaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine 5-phosphate aminohydrolase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP aminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylate desaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenyl deaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP deaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-adenylic acid deaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine monophosphate deaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-AMP deaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-adenylate deaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	myoadenylate deaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylic acid deaminase activity
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylate deaminase reaction
GO:0003876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine 5-monophosphate deaminase activity
RHEA:50506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-seryl-[protein]
RHEA:54599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + hexadecanoyl-CoA + O2 <=> 2-hydroxyhexadecanoyl-CoA + CO2 + succinate
GO:0106423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulinyl-Tyr carboxypeptidase
GO:0106423	skos:altLabel	"carboxypeptidase-tubulin"
GO:0106423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine
GO:0106423	skos:prefLabel	"tubulinyl-Tyr carboxypeptidase"
GO:0106423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tubulinyl-Tyr carboxypeptidase"
GO:0106423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin-tyrosine carboxypeptidase
GO:0106423	skos:altLabel	"soluble carboxypeptidase"
REACT:R-XTR-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Xenopus tropicalis)
REACT:R-MMU-9678935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Mus musculus)
REACT:R-MMU-8987223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10RB binds TYK2 (Mus musculus)
RHEA:53486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+) => androst-4-ene-3,11,17-trione + H(+) + NADPH
REACT:R-MMU-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Mus musculus)
RHEA:33442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + H2O + O2 <=> glyoxylate + H(+) + H2O2
RHEA:22145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate + H2O => D-threo-isocitrate
RHEA:19371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine
EC:2.4.1.202	skos:altLabel	"DIMBOA glucosyltransferase"
EC:2.4.1.202	skos:prefLabel	"2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase"
EC:2.4.1.202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase"
REACT:R-HSA-1250348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by ERBB4 homodimers (Homo sapiens)
RHEA:64436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L-isoleucine(in) + H(+)(in)
REACT:R-CFA-8952823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Canis familiaris)
REACT:R-MMU-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Mus musculus)
REACT:R-XTR-390641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA1A,B,D bind ADR,NAd (Xenopus tropicalis)
RHEA:30937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-ribosylnicotinate + phosphate => H2O + nicotinate beta-D-ribonucleotide
RHEA:56535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate <=> N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate
RHEA:65996	skos:altLabel	"glycine betaine methyltransferase"
RHEA:65996	skos:prefLabel	"glycine betaine--corrinoid protein Co-methyltransferase"
RHEA:65996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) = methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine
RHEA:65996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine betaine--corrinoid protein Co-methyltransferase"
REACT:R-MMU-936390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD mediated deubiquitination of DDX58 (RIG-I) (Mus musculus)
REACT:R-BTA-77329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Bos taurus)
RHEA:30380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-beta-chamigrene + diphosphate
REACT:R-HSA-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Homo sapiens)
REACT:R-HSA-380229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)
REACT:R-SSC-173745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3(H2O)-bound Factor B (Sus scrofa)
REACT:R-DRE-211193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization  of DFF40 (Danio rerio)
EC:1.5.5.2	skos:prefLabel	"proline dehydrogenase"
EC:1.5.5.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"proline dehydrogenase"
RHEA:34970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate(in) <=> sn-glycerol 3-phosphate(out)
RHEA:48860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-HEPE + O2 = (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate
REACT:R-MMU-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Mus musculus)
RHEA:60959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP
RHEA:51904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate
RHEA:66864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + quiannulatene
GO:0050210	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prenol pyrophosphatase activity
GO:0050210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenyl-diphosphatase activity
GO:0050210	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prenyl-diphosphate diphosphohydrolase activity
GO:0050210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prenyl-pyrophosphatase activity
GO:0050210	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prenylphosphatase activity
REACT:R-MMU-350318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at TNLD (429) (Mus musculus)
GO:0102392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoate-[HmqF protein] ligase activity
REACT:R-HSA-8948232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Homo sapiens)
RHEA:42358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA => (9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA
REACT:R-CEL-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Caenorhabditis elegans)
REACT:R-XTR-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Xenopus tropicalis)
RHEA:46392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)
RHEA:46104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = corticosterone + H2O + 2 oxidized [adrenodoxin]
RHEA:60743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(-)-citronellal + H2O + NADP(+) <=> (S)-(-)-citronellate + 2 H(+) + NADPH
REACT:R-RNO-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Rattus norvegicus)
REACT:R-RNO-8851859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds RANBP9 and SOS1 (Rattus norvegicus)
REACT:R-HSA-2046239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular KSPG translocates to the lysosome for degradation (Homo sapiens)
REACT:R-CEL-8868402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Caenorhabditis elegans)
REACT:R-GGA-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Gallus gallus)
RHEA:66735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate
REACT:R-BTA-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-SSC-5654392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
GO:0101016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-binding domain binding
REACT:R-PFA-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Plasmodium falciparum)
REACT:R-DDI-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Dictyostelium discoideum)
GO:0047212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-coumarate O-beta-glucosyltransferase activity
GO:0047212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity
GO:0047212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity
GO:0047212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG:o-coumaric acid O-glucosyltransferase activity
GO:0047212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-o-coumarate glucosyltransferase activity
REACT:R-MMU-6810234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Mus musculus)
RHEA:71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) = H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)
GO:0008893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity
GO:0008893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PpGpp-3'-pyrophosphohydrolase activity
GO:0008893	skos:prefLabel	"guanosine-3',5'-bis(diphosphate) 3'-diphosphatase"
GO:0008893	skos:altLabel	"Penta-phosphate guanosine-3'-pyrophosphohydrolase"
GO:0008893	skos:altLabel	"Penta-phosphate guanosine-3'-diphosphohydrolase"
GO:0008893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity
GO:0008893	skos:altLabel	"Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase"
GO:0008893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
GO:0008893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PpGpp phosphohydrolase activity
GO:0008893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanosine-3',5'-bis(diphosphate) 3'-diphosphatase"
GO:0008893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penta-phosphate guanosine-3'-diphosphohydrolase activity
GO:0008893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(ppGpp)ase activity
GO:0008893	skos:altLabel	"(ppGpp)ase"
GO:0008893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity
GO:0008893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	penta-phosphate guanosine-3'-pyrophosphohydrolase activity
RHEA:25866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(1)-acetylspermidine + O2
REACT:R-CFA-2076611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3STs sulfate GlcN at C3 in heparan sulfate (Canis familiaris)
EC:4.99.1.6	skos:altLabel	"3-indoleacetaldoxime hydro-lyase"
EC:4.99.1.6	skos:altLabel	"indole-3-acetaldehyde-oxime hydro-lyase"
EC:4.99.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indoleacetaldoxime dehydratase"
EC:4.99.1.6	skos:altLabel	"indoleacetaldoxime hydro-lyase"
EC:4.99.1.6	skos:prefLabel	"indoleacetaldoxime dehydratase"
REACT:R-HSA-2201316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
RHEA:67631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dGMP + L-aspartate <=> (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate
REACT:R-XTR-192312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Xenopus tropicalis)
REACT:R-HSA-434362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment Of Cytoplasmic Proteins To Vesicles (Homo sapiens)
GO:0047841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ketogluconate kinase activity
GO:0047841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogluconokinase activity
GO:0047841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydogluconokinase activity
GO:0047841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:2-dehydro-D-gluconate 6-phosphotransferase activity
GO:0047841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-ketogluconokinase activity
GO:0047841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketogluconokinase (phosphorylating)
GO:0047841	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketogluconokinase activity
RHEA:29881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-arginine(in) + phosphate => ATP + H2O + L-arginine(out)
REACT:R-MMU-2731078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 2, (4) bind TGFB1 (Mus musculus)
RHEA:31975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxusin = 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-5654407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates SHC1 (Rattus norvegicus)
RHEA:62242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymine-cytidine dinucleotide in DNA => a thymidine(6-4)cytidine in DNA
REACT:R-SSC-1169405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein phosphatase 1 beta (PP2CB) (Sus scrofa)
RHEA:50400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[PqsC protein] + octanoyl-CoA = CoA + S-octanoyl-L-cysteinyl-[PqsC protein]
GO:0018748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iprodione amidohydrolase activity
GO:0071074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eukaryotic initiation factor eIF2 binding
RHEA:19964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate <=> a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside
REACT:R-CEL-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)
RHEA:18137	skos:prefLabel	"3beta-hydroxy-5alpha-steroid dehydrogenase"
RHEA:18137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3beta-hydroxy-5alpha-steroid dehydrogenase"
RHEA:18137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH
REACT:R-HSA-9665000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)
RHEA:51769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate => 4-prenylphlormethylbutanophenone + diphosphate
RHEA:28221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + H(+) + H2O2 <=> H2O + hypochlorous acid
REACT:R-HSA-5610763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Homo sapiens)
REACT:R-GGA-422104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase octanoylates Proghrelin (Gallus gallus)
REACT:R-HSA-6788611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYKK phosphorylates 5HLYS (Homo sapiens)
REACT:R-XTR-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)
REACT:R-CFA-9638097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)
REACT:R-RNO-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Rattus norvegicus)
RHEA:45592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-HSA-5655323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
REACT:R-XTR-202500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of IKK complex (Xenopus tropicalis)
REACT:R-MMU-1169402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of E2 conjugating enzymes (Mus musculus)
REACT:R-SSC-5635102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 is internalized (Sus scrofa)
REACT:R-GGA-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Gallus gallus)
REACT:R-DME-8854222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D3 associates with RAB5 (Drosophila melanogaster)
REACT:R-SSC-389350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 by pVav1 (Sus scrofa)
REACT:R-DME-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Drosophila melanogaster)
REACT:R-SSC-169905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS is phosphorylated by active TrkA receptor (Sus scrofa)
REACT:R-GGA-420739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPRC6A can bind L-alpha amino acids and calcium (Gallus gallus)
REACT:R-DDI-9755078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C2 tetramer dephosphorylates RBV-MP (Dictyostelium discoideum)
REACT:R-SSC-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Sus scrofa)
REACT:R-CFA-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Canis familiaris)
RHEA:47957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-maleylpyruvate + H2O => H(+) + maleate + pyruvate
RHEA:55124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH = 5-methylhexanoyl-[ACP] + NAD(+)
REACT:R-DME-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)
RHEA:67351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-beta-D-glucoside + malonyl-CoA <=> apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA
REACT:R-CEL-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Caenorhabditis elegans)
RHEA:59732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinyl-5'-AMP + L-lysyl-[protein] = AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]
REACT:R-CFA-110353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MBD4 glycosylase by APEX1 at the AP site (Canis familiaris)
GO:0102102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homocarnosine synthase activity
REACT:R-SCE-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Saccharomyces cerevisiae)
RHEA:18905	skos:prefLabel	"phosphonoacetaldehyde hydrolase"
RHEA:18905	skos:altLabel	"phosphonoacetylaldehyde phosphonohydrolase"
RHEA:18905	skos:altLabel	"phosphonatase"
RHEA:18905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate
RHEA:18905	skos:altLabel	"2-phosphonoacetylaldehyde phosphonohydrolase"
RHEA:18905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphonoacetaldehyde hydrolase"
REACT:R-GGA-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Gallus gallus)
RHEA:44890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O
REACT:R-RNO-9012268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)
REACT:R-HSA-9664950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)
REACT:R-BTA-159050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Bos taurus)
REACT:R-RNO-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Rattus norvegicus)
REACT:R-SSC-193393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Sus scrofa)
REACT:R-CEL-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Caenorhabditis elegans)
RHEA:29305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + succinate(out) => 2 H(+)(in) + succinate(in)
REACT:R-HSA-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Homo sapiens)
REACT:R-CFA-9686088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP3 cleaves GSDMD (Canis familiaris)
REACT:R-HSA-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Homo sapiens)
REACT:R-BTA-9700200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)
REACT:R-RNO-6809309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR6 binds MTMR9 (Rattus norvegicus)
RHEA:63415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trichlorophenol + FADH2 + O2 <=> 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O
GO:0098639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	collagen binding involved in cell-matrix adhesion
RHEA:33096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + inosine + phosphoenolpyruvate => futalosine
EC:3.2.1.60	skos:altLabel	"G4-amylase"
EC:3.2.1.60	skos:altLabel	"glucan 1,4-alpha-maltotetrahydrolase"
EC:3.2.1.60	skos:prefLabel	"glucan 1,4-alpha-maltotetraohydrolase"
EC:3.2.1.60	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucan 1,4-alpha-maltotetraohydrolase"
EC:3.2.1.60	skos:altLabel	"exo-maltotetraohydrolase"
EC:3.2.1.60	skos:altLabel	"maltotetraose-forming amylase"
REACT:R-RNO-2534248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP2, MMP3, MMP7 (Rattus norvegicus)
RHEA:35093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine => anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine
REACT:R-DRE-1675810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Danio rerio)
REACT:R-CEL-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Caenorhabditis elegans)
REACT:R-MMU-445705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release Of ADP From Myosin (Mus musculus)
REACT:R-DME-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Drosophila melanogaster)
REACT:R-MMU-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Mus musculus)
REACT:R-HSA-201423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI complexes with the Smad complex, suppressing BMP2 signalling (Homo sapiens)
REACT:R-RNO-8864029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates EGFR at Y1148 (Y1172) (Rattus norvegicus)
REACT:R-MMU-391211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trace amine-associated receptors can bind trace amines (Mus musculus)
REACT:R-DRE-5694431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Danio rerio)
RHEA:51735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glandicoline B + S-adenosyl-L-methionine <=> H(+) + meleagrin + S-adenosyl-L-homocysteine
RHEA:39123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA
REACT:R-XTR-9702354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCA antibodies (Xenopus tropicalis)
REACT:R-RNO-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Rattus norvegicus)
REACT:R-DRE-8851797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 in ADRB2:GRK complex is phosphorylated (Danio rerio)
REACT:R-MMU-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Mus musculus)
RHEA:13719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH => 2-C-methyl-D-erythritol 4-phosphate + NADP(+)
GO:0102945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol B UDP-glucosyl transferase activity
REACT:R-GGA-508247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
REACT:R-GGA-5696960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP49 deubiquitinates H2B (Gallus gallus)
REACT:R-HSA-9698026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)
RHEA:53203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:14230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0043805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indolepyruvate oxidoreductase activity
GO:0043805	skos:altLabel	"IOR"
GO:0043805	skos:altLabel	"3-(indol-3-yl)pyruvate synthase (ferredoxin)"
GO:0043805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)
GO:0043805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indolepyruvate ferredoxin oxidoreductase"
GO:0043805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-(indol-3-yl)pyruvate synthase (ferredoxin) activity
GO:0043805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IOR
GO:0043805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0043805	skos:prefLabel	"indolepyruvate ferredoxin oxidoreductase"
GO:0043805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indolepyruvate ferredoxin oxidoreductase activity
EC:1.14.13.107	skos:prefLabel	"limonene 1,2-monooxygenase"
EC:1.14.13.107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limonene 1,2-monooxygenase"
REACT:R-DDI-109863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK3:MAP2K1 (Dictyostelium discoideum)
REACT:R-SSC-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Sus scrofa)
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyoctanoyl-ACP-dehydrase activity
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctanoyl-ACP dehydratase activity
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity
GO:0047451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyoctanoyl thioester dehydratase activity
REACT:R-SPO-192430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)
RHEA:46536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:33718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyeicosasphinganine 1-phosphate <=> 2-hydroxyoctadecanal + phosphoethanolamine
REACT:R-CFA-373747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of nephrin by FYN (Canis familiaris)
RHEA:23139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary amine + S-adenosyl-L-methionine <=> a methylated primary amine + H(+) + S-adenosyl-L-homocysteine
RHEA:19739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + L-glutamate => 4-(gamma-L-glutamylamino)butanoate + H2O
RHEA:12950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fuconate => 2-dehydro-3-deoxy-D-fuconate + H2O
RHEA:61441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + S-(2-succino)-L-cysteine => CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine
REACT:R-DDI-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Dictyostelium discoideum)
REACT:R-XTR-8983298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Xenopus tropicalis)
RHEA:12695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+) => 3,4-dihydroxypyridine + O-acetyl-L-serine
REACT:R-CFA-373734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin interacts with Podocin (Canis familiaris)
REACT:R-MMU-1297333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Acrosin Heavy and Light Chain (Mus musculus)
RHEA:19113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-heptadecatrienal + A + H2O = (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)
RHEA:25446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,4E)-germacrene B + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:49223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP <=> CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate
RHEA:45621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine
REACT:R-CFA-173488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
REACT:R-HSA-2248891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARSA translocates to the lysosome (Homo sapiens)
RHEA:51679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [protein]-dithiol + 2 AH2 + H(+) + sulfite
REACT:R-HSA-6803234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RHEA:58776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3-carbaldehyde
REACT:R-GGA-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Gallus gallus)
RHEA:69541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + streptomycin => 6-O-guanylylstreptomycin + diphosphate
REACT:R-BTA-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Bos taurus)
REACT:R-CEL-189465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FECH binds Fe2+ to PRIN9 to form heme (Caenorhabditis elegans)
RHEA:33748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + ATP => a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SCE-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)
RHEA:56445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate
EC:1.3.1.-	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
EC:1.3.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
REACT:R-GGA-210290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHIP (Gallus gallus)
REACT:R-GGA-6801666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates CENPJ (Gallus gallus)
REACT:R-HSA-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Homo sapiens)
REACT:R-RNO-964768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the glycan on the A arm (Rattus norvegicus)
RHEA:16418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) => H(+) + L-glutamate + NADH
REACT:R-DME-209157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase (Drosophila melanogaster)
RHEA:34769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+) => 5,10-methenyltetrahydrofolate + H2O
RHEA:55150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH => a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+)
RHEA:29116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinone-8 + NADPH => menaquinol-8 + NADP(+)
REACT:R-BTA-9018895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Bos taurus)
REACT:R-DDI-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)
GO:0050188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate mutase activity
GO:0050188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate 2,3-phosphonomutase activity
GO:0050188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate-phosphonopyruvate phosphomutase activity
GO:0050188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEP phosphomutase activity
GO:0050188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEPPM
GO:0050188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate phosphomutase activity
GO:0050188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEP mutase activity
RHEA:43608	skos:altLabel	"tRNA(Ile)-agmatidine synthetase"
RHEA:43608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate
RHEA:43608	skos:altLabel	"tRNA(Ile)-2-agmatinylcytidine synthetase"
RHEA:43608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Ile)(2)-agmatinylcytidine synthase"
RHEA:43608	skos:altLabel	"tRNA(Ile)-agm(2)C synthetase"
RHEA:43608	skos:prefLabel	"tRNA(Ile)(2)-agmatinylcytidine synthase"
RHEA:69366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine => 6-diazo-5-oxo-L-norleucine + acetyl-CoA
RHEA:70271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
RHEA:47268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacterioruberin = H2O + monoanhydrobacterioruberin
EC:2.4.1.363	skos:prefLabel	"ginsenoside 20-O-glucosyltransferase"
EC:2.4.1.363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ginsenoside 20-O-glucosyltransferase"
EC:2.4.1.363	skos:altLabel	"UGT71A27"
RHEA:20671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+)
REACT:R-CFA-350318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at TNLD (429) (Canis familiaris)
REACT:R-GGA-5635855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Gallus gallus)
REACT:R-HSA-210769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF6- and FGF10-dependent synthesis of PDX1 protein (Homo sapiens)
RHEA:44076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + pentadecanoate = AMP + diphosphate + pentadecanoyl-CoA
RHEA:60338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine
RHEA:56218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:41834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-[ACP] + NADP(+) => (2E)-hexenoyl-[ACP] + H(+) + NADPH
REACT:R-GGA-4568848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Gallus gallus)
REACT:R-MMU-1461971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Mus musculus)
REACT:R-XTR-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Xenopus tropicalis)
REACT:R-SSC-1168459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lyn activates ERK (Sus scrofa)
GO:0070735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein glycylase activity
GO:0070735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glycine ligase activity
GO:0070735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)
REACT:R-DRE-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Danio rerio)
RHEA:49397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-5672973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
REACT:R-DME-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)
RHEA:62802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + NADP(+) + orlandin => 2 7-demethylsiderin + NADPH + O2
REACT:R-BTA-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Bos taurus)
GO:1990521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	m7G(5')pppN diphosphatase activator activity
RHEA:61111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-1980233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Rattus norvegicus)
RHEA:62276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine = 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine
GO:0030562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA 2'-O-ribose methylation guide activity
REACT:R-SCE-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Saccharomyces cerevisiae)
RHEA:40447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-pristanoyl-CoA = (2S)-pristanoyl-CoA
REACT:R-HSA-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Homo sapiens)
RHEA:13583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP => N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-MMU-192178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)
REACT:R-RNO-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Rattus norvegicus)
REACT:R-RNO-445757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1 receptor antagonist protein binds Interleukin 1 receptors (Rattus norvegicus)
REACT:R-DRE-5672948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK3 phosphorylates KSR1 (Danio rerio)
REACT:R-SSC-5607732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TAK1 autophosphorylates (Sus scrofa)
RHEA:67658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome c] + NADPH
RHEA:28053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) <=> NAD(+) + phosphate
REACT:R-GGA-6782628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates STAM2:HGS (Gallus gallus)
RHEA:40974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:36613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate => (3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2
EC:1.14.15.16	skos:prefLabel	"vitamin D3 24-hydroxylase"
EC:1.14.15.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vitamin D3 24-hydroxylase"
EC:1.14.15.16	skos:altLabel	"CYP24A1"
REACT:R-DRE-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Danio rerio)
REACT:R-SCE-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Saccharomyces cerevisiae)
REACT:R-DRE-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Danio rerio)
REACT:R-BTA-8948034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds LDL:LRP8 (Bos taurus)
REACT:R-BTA-170072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Bos taurus)
REACT:R-BTA-453111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
RHEA:50261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione => (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate
RHEA:21634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1,2-benzoquinone + 2 H2O => 2 catechol + O2
RHEA:71004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(in) + L-phenylalanine(out) => L-histidine(out) + L-phenylalanine(in)
REACT:R-XTR-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Xenopus tropicalis)
RHEA:36439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate
REACT:R-XTR-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Xenopus tropicalis)
RHEA:47163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carboxylate + NAD(+) <=> 3-dehydro-4-methylzymosterol + CO2 + NADH
RHEA:14379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + glyoxylate => (3R)-3-hydroxy-L-aspartate
RHEA:61076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-minovincinine + acetyl-CoA = (-)-echitovenine + CoA
RHEA:59361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine + H2O => beta-alanine + L-histidine
REACT:R-CFA-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Canis familiaris)
REACT:R-DME-350391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHO1:GTP binds to activated DAAM (Drosophila melanogaster)
REACT:R-GGA-9755304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUL1 ubiquitinates UBXN7 (Gallus gallus)
RHEA:18751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + H(+) + NADH => [protein]-dithiol + NAD(+)
REACT:R-BTA-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Bos taurus)
RHEA:53680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
REACT:R-MTU-964851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydratation of DHQ yields DHS (Mycobacterium tuberculosis)
RHEA:22252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase"
RHEA:22252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer (d18:1(4E)) + H(+) + UDP
RHEA:22252	skos:altLabel	"galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase"
RHEA:22252	skos:prefLabel	"globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase"
RHEA:22252	skos:altLabel	"globoside synthetase"
RHEA:22252	skos:altLabel	"uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase"
RHEA:22252	skos:altLabel	"beta3GalNAc-T1"
RHEA:22252	skos:altLabel	"globoside synthase"
REACT:R-XTR-8850594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Xenopus tropicalis)
REACT:R-XTR-3229089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Xenopus tropicalis)
REACT:R-CFA-2187330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
RHEA:11250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+) => [(3R)-hydroxybutanoate](n) + H2O
RHEA:15953	skos:altLabel	"phosphagen phosphokinase"
RHEA:15953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + ATP = ADP + 2 H(+) + N(4)-phosphoagmatine
RHEA:15953	skos:prefLabel	"agmatine kinase"
RHEA:15953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"agmatine kinase"
REACT:R-SCE-6811504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 dephosphorylation by PP2A-B56-beta,gamma (Saccharomyces cerevisiae)
REACT:R-MMU-5626699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK4 binds ODF2 in the centriole (Mus musculus)
RHEA:68266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + formaldehyde => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O
RHEA:25859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-BTA-1112703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 is phosphorylated (Bos taurus)
REACT:R-DRE-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Danio rerio)
RHEA:42091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0008993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnulokinase activity
GO:0008993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rhamnulose kinase activity
GO:0008993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnulokinase activity
GO:0008993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnulose kinase activity
GO:0008993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:L-rhamnulose 1-phosphotransferase activity
GO:0008993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rhamnulokinase (phosphorylating)
GO:0008993	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RhuK
REACT:R-DRE-3000120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLIF binds RCbl (Danio rerio)
RHEA:47700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ketocytochalasin + NADPH + O2 = H2O + iso-precytochalasin + NADP(+)
REACT:R-GGA-75083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Gallus gallus)
REACT:R-XTR-6804229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMY, TTC5 and EP300 bind (Xenopus tropicalis)
REACT:R-HSA-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Homo sapiens)
RHEA:57830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate + hypoxanthine => dIMP + H2O
RHEA:52573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + NAD(+) => (2E)-butenoyl-CoA + H(+) + NADH
REACT:R-DRE-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Danio rerio)
REACT:R-RNO-158860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates NHABP (Rattus norvegicus)
REACT:R-DME-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)
RHEA:68128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + phytol = a fatty acid phytyl ester + CoA
REACT:R-CFA-8952371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds RUNX3 (Canis familiaris)
REACT:R-BTA-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)
REACT:R-SSC-6785213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer binds heparin (Sus scrofa)
RHEA:58161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate => diphosphate + dolabradiene
GO:0047997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxypyruvate decarboxylase activity
GO:0047997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)
GO:0047997	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxypyruvate carboxy-lyase activity
RHEA:28960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose(in) + H(+)(in) => D-xylose(out) + H(+)(out)
GO:0047048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	m-hydroxybenzyl alcohol dehydrogenase activity
GO:0047048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity
GO:0047048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	m-hydroxybenzylalcohol dehydrogenase activity
GO:0047048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl-alcohol dehydrogenase activity
GO:0047048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	m-hydroxybenzyl alcohol (NADP) dehydrogenase activity
REACT:R-HSA-192056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Homo sapiens)
RHEA:59227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + hydropyrene
REACT:R-BTA-374701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DCC by Fyn (Bos taurus)
GO:0047499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-independent phospholipase A2 activity
GO:0047499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Homo sapiens)
GO:0047499	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calcium-independent cytosolic phospholipase A2 activity
REACT:R-DRE-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Danio rerio)
RHEA:15730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NAD(+) => H(+) + keto-D-fructuronate + NADH
EC:2.7.11.14	skos:altLabel	"G-protein-coupled receptor kinase 1"
EC:2.7.11.14	skos:altLabel	"opsin kinase (phosphorylating)"
EC:2.7.11.14	skos:prefLabel	"rhodopsin kinase"
EC:2.7.11.14	skos:altLabel	"cone opsin kinase"
EC:2.7.11.14	skos:altLabel	"RK"
EC:2.7.11.14	skos:altLabel	"GPCR kinase 1"
EC:2.7.11.14	skos:altLabel	"opsin kinase"
EC:2.7.11.14	skos:altLabel	"rhodopsin kinase (phosphorylating)"
EC:2.7.11.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhodopsin kinase"
REACT:R-HSA-432909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Plectin with Integrin beta 4 (Homo sapiens)
REACT:R-CFA-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Canis familiaris)
RHEA:60351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
REACT:R-XTR-5251942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hikeshi binds HSP70s:ATP (Xenopus tropicalis)
GO:0016894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
GO:0016894	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
GO:0016894	skos:prefLabel	"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters"
GO:0016894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-endonuclease activity
GO:0016894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters"
REACT:R-PFA-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)
REACT:R-BTA-8985594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYO9B inactivates RHOA (Bos taurus)
REACT:R-DRE-6805573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I/type II heterodimers form tetramers (Danio rerio)
REACT:R-CFA-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)
RHEA:34863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2,3-didehydroadipyl-CoA + H2O = 3-hydroxyadipyl-CoA
REACT:R-MMU-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Mus musculus)
RHEA:45342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+) => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O
REACT:R-DDI-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Dictyostelium discoideum)
REACT:R-CFA-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Canis familiaris)
REACT:R-SPO-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Schizosaccharomyces pombe)
REACT:R-CFA-2032794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ), TBX5, and PCAF form a complex (Canis familiaris)
REACT:R-GGA-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Gallus gallus)
RHEA:55151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH
RHEA:21208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-serine = L-serine + phosphate
RHEA:66209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-8-hydroxynonanoyl-CoA + O2 => (2E,8R)-8-hydroxynonenoyl-CoA + H2O2
REACT:R-DRE-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Danio rerio)
RHEA:44157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 5-phosphate + H2O => myo-inositol + phosphate
RHEA:29353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zn(2+)(out) => Zn(2+)(in)
REACT:R-HSA-162830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)
REACT:R-DRE-5676917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Danio rerio)
REACT:R-SSC-8865482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KMT2A (MLL) binds RUNX1 (Sus scrofa)
REACT:R-GGA-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Gallus gallus)
REACT:R-HSA-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Homo sapiens)
REACT:R-RNO-5682598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates HERC2 (Rattus norvegicus)
RHEA:33701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O => C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:16840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-acylphosphoadenosine + H2O <=> a carboxylate + AMP + 2 H(+)
GO:0046923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoplasmic reticulum retention sequence binding
GO:0046923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ER retention sequence binding
REACT:R-RNO-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Rattus norvegicus)
RHEA:72412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inulobiose => alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O
REACT:R-XTR-164423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PhosphoChREBP (Thr 666)  is exported to cytosol (Xenopus tropicalis)
RHEA:72929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV => O2 + proatranorin I + reduced [NADPH--hemoprotein reductase]
RHEA:10933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + L-citrulline => 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
REACT:R-HSA-9715355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lorlatinib-resistant ALK mutants don't bind lorlatinib (Homo sapiens)
REACT:R-HSA-9626067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF1A1:GTP translocates from lysosomal membrane to cytosol (Homo sapiens)
REACT:R-GGA-9634834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACHEIs bind ACHE (Gallus gallus)
REACT:R-SCE-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Saccharomyces cerevisiae)
REACT:R-XTR-9029690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-6 translocates to the nucleus (Xenopus tropicalis)
REACT:R-CEL-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)
REACT:R-HSA-9694499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)
RHEA:46916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + juvenile hormone I = H(+) + juvenile hormone I carboxylate + methanol
RHEA:28574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + sulfate(in) = H(+)(out) + sulfate(out)
RHEA:41920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)
REACT:R-XTR-8857928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIHBP1 binds HSPG:LPL dimer (Xenopus tropicalis)
RHEA:28527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + crotonobetainyl-CoA => (R)-carnitinyl-CoA + crotonobetaine
REACT:R-DRE-420586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Necl-2 trans heterodimer interaction (Danio rerio)
RHEA:13754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + L-glutamine + NADH
REACT:R-XTR-375790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Xenopus tropicalis)
GO:0098697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels
RHEA:19369	skos:prefLabel	"protein-histidine N-methyltransferase"
RHEA:19369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-histidine N-methyltransferase"
RHEA:19369	skos:altLabel	"protein methylase IV"
RHEA:19369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine
RHEA:44783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-9 + S-adenosyl-L-methionine <=> H(+) + menaquinol-9 + S-adenosyl-L-homocysteine
GO:0016005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase A2 activator activity
REACT:R-MMU-8849908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM4 binds flotillin-1 (Mus musculus)
REACT:R-HSA-9699007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
REACT:R-HSA-9761844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent IDH1 gene expression (Homo sapiens)
REACT:R-DRE-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Danio rerio)
RHEA:16252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> beta-D-glucose 6-phosphate
RHEA:58483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in mRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate
REACT:R-HSA-5655733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region (Homo sapiens)
REACT:R-RNO-5668731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX3 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)
REACT:R-DME-2022919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Drosophila melanogaster)
REACT:R-SPO-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Schizosaccharomyces pombe)
REACT:R-XTR-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Xenopus tropicalis)
RHEA:35225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-dAMP + H(+) + phosphate => 2-oxo-dADP + H2O
REACT:R-HSA-6806392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates MLH1 expression (Homo sapiens)
REACT:R-BTA-2870221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-selectin binds E-selectin ligand (Bos taurus)
REACT:R-DRE-199206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Danio rerio)
REACT:R-DME-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Drosophila melanogaster)
RHEA:51455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate <=> beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP
REACT:R-SSC-8874206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves CREB3L3 (Sus scrofa)
REACT:R-BTA-6805470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates TP53 (Bos taurus)
RHEA:42823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NADP(+) + tetracenomycin C
REACT:R-HSA-8852130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
GO:0019912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity
GO:0019912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclin-dependent protein kinase activating kinase activity
GO:0019912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cdk-activating kinase activity
GO:0019912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK
RHEA:22732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + H(+) = 4-methylphenol + CO2
REACT:R-GGA-3000449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Gallus gallus)
REACT:R-CEL-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Caenorhabditis elegans)
REACT:R-HSA-984708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-2 is a heterotrimer (Homo sapiens)
RHEA:33453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] => A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein]
REACT:R-GGA-9696179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Gallus gallus)
REACT:R-CFA-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Canis familiaris)
RHEA:64052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine = CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine
RHEA:13425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a pyrimidine ribonucleoside 5'-phosphate + H2O = a pyrimidine nucleobase + D-ribose 5-phosphate
GO:1990147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	talin binding
RHEA:26093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)
REACT:R-HSA-8932765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) (Homo sapiens)
REACT:R-MMU-8983878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Mus musculus)
RHEA:49972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-PFA-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)
GO:0140828	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	solute:metal cation antiporter activity
GO:0140828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal cation:monoatomic cation antiporter activity
GO:0033453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine tRNA
GO:0033453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCT codon-amino acid adaptor activity
GO:0033453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCU codon-amino acid adaptor activity
GO:0008716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanylalanine synthetase activity
GO:0008716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanylalanine synthetase activity
GO:0008716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine:alanine ligase (ADP-forming) activity
GO:0008716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl-D-alanine synthetase activity
GO:0008716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanine:D-alanine ligase (ADP-forming)
GO:0008716	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-Ala-D-Ala synthetase activity
GO:0008716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine-D-alanine ligase activity
RHEA:64932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + 2 H2O = dGMP + 2 H(+) + 2 phosphate
RHEA:14703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-disulfide + H(+) + NADH => 2 CoA + NAD(+)
REACT:R-HSA-5656248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes) (Homo sapiens)
RHEA:35978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 <=> A + CO2 + H2O + succinate + verruculogen
REACT:R-DRE-380283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Danio rerio)
RHEA:39439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA = (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O
RHEA:47578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GD1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E))
GO:0034573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	didemethylisoproturon amidohydrolase activity
REACT:R-CFA-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
GO:0004354	skos:prefLabel	"glutamate dehydrogenase (NADP(+))"
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamic acid dehydrogenase
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H-dependent glutamate dehydrogenase activity
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-glutamate dehydrogenase
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamic acid dehydrogenase activity
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:NADP+ oxidoreductase (deaminating)
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)-glutamate dehydrogenase activity
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamic dehydrogenase activity
GO:0004354	skos:altLabel	"glutamic dehydrogenase"
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate dehydrogenase (NADP+) activity
GO:0004354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate dehydrogenase (NADP(+))"
REACT:R-DDI-9603986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 chains to form LeA (Dictyostelium discoideum)
REACT:R-DRE-416562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGAP binds Plexin-B1 (Danio rerio)
RHEA:36713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CO2 + D-cycloserine + NH4(+) + phosphate => ATP + H(+) + H2O + O-ureido-D-serine
RHEA:18367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADH + pyruvate => (R)-malate + NAD(+)
REACT:R-MMU-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Mus musculus)
REACT:R-MMU-3000383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I, HDAC7 SUMOylate PML with SUMO1 (Mus musculus)
REACT:R-BTA-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Bos taurus)
REACT:R-HSA-8951552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTF:2xCO3(2-) dissociates from Carbocymycobactin:Fe3+ (Homo sapiens)
REACT:R-RNO-216076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Rattus norvegicus)
REACT:R-DRE-8874208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Danio rerio)
REACT:R-HSA-381518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAAP-A proteolyzes IGF:IGFBP4 (Homo sapiens)
REACT:R-MMU-6805811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SEPT4 from mitochondria (Mus musculus)
REACT:R-CFA-176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST trimers transfer GS from GSH to luminal substrates (Canis familiaris)
GO:0034480	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Clostridium oedematiens beta- and gamma-toxins activity
GO:0034480	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heat-labile hemolysin
GO:0034480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine
GO:0034480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phospholipase C"
GO:0034480	skos:altLabel	"lipophosphodiesterase I"
GO:0034480	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Clostridium welchii alpha-toxin activity
GO:0034480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phospholipase C, acting on phosphatidylcholine
GO:0034480	skos:altLabel	"Clostridium welchii alpha-toxin"
GO:0034480	skos:prefLabel	"phospholipase C"
GO:0034480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine phospholipase C activity
GO:0034480	skos:altLabel	"lecithinase C"
GO:0034480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylcholine cholinephosphohydrolase activity
GO:0034480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipophosphodiesterase I activity
GO:0034480	skos:altLabel	"Clostridium oedematiens beta- and gamma-toxins"
REACT:R-HSA-173740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to C3(H2O) (Homo sapiens)
RHEA:26361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-iminoacetate synthase"
RHEA:26361	skos:prefLabel	"2-iminoacetate synthase"
RHEA:26361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + NADPH + S-adenosyl-L-methionine = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)
REACT:R-XTR-5693925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers L-fucose to Gal1,3GlcNAc (Xenopus tropicalis)
RHEA:48407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aryl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]
GO:0015156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose transmembrane transporter activity
GO:0045289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luciferin monooxygenase activity
GO:0045289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luciferase activity
GO:0045289	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	luciferase monooxygenase activity
RHEA:30842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-beta-L-talose <=> UDP-N-acetyl-beta-L-fucosamine
REACT:R-CFA-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Canis familiaris)
REACT:R-BTA-1183128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Bos taurus)
RHEA:58228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparaginyl-[protein] + NAD(+) = H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide
RHEA:53981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
REACT:R-CFA-870538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Canis familiaris)
RHEA:34984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate(in) => sulfate(out)
RHEA:66806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate => ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
RHEA:72703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-galactose(in) + UMP(out) = UDP-alpha-D-galactose(out) + UMP(in)
RHEA:50642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmalate
REACT:R-DRE-1602454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proMMP9 binds TIMP1 (Danio rerio)
REACT:R-HSA-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)
RHEA:45736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA
REACT:R-BTA-2201293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of TLR4:LY96:LPS:CD14 (Bos taurus)
RHEA:64096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] = 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]
RHEA:44757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:12901	skos:prefLabel	"D-arginase"
RHEA:12901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arginine + H2O = D-ornithine + urea
RHEA:12901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arginase"
REACT:R-RNO-5621366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to p-Y65,Y76-FCER1G (Rattus norvegicus)
RHEA:21095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxydihydrochelirubine + S-adenosyl-L-methionine <=> dihydromacarpine + H(+) + S-adenosyl-L-homocysteine
RHEA:15718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daunorubicin + H(+) + NADPH + O2 => doxorubicin + H2O + NADP(+)
RHEA:38584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate
REACT:R-BTA-981713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4b binds to cell surface (Bos taurus)
RHEA:54184	skos:altLabel	"aminoacylase 3"
RHEA:54184	skos:altLabel	"aminoacylase III"
RHEA:54184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acyl-aromatic-L-amino acid amidohydrolase"
RHEA:54184	skos:prefLabel	"N-acyl-aromatic-L-amino acid amidohydrolase"
RHEA:54184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-aromatic L-alpha-amino acid + H2O = a carboxylate + an aromatic L-alpha-amino acid
REACT:R-HSA-4396402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants bind promoters of HEY genes (Homo sapiens)
REACT:R-GGA-844447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 senses MDP (Gallus gallus)
RHEA:59040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:32259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1-phosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde
RHEA:64810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + O-(2-acetamidoethyl)-L-serine => acetyl-CoA + O-(2-aminoethyl)-L-serine
RHEA:53606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycerol + phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O
RHEA:66159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + tyramine <=> CoA + H(+) + N-butanoyltyramine
REACT:R-HSA-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Homo sapiens)
REACT:R-XTR-429567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Xenopus tropicalis)
REACT:R-DRE-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Danio rerio)
REACT:R-SCE-1482862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolysed to 2-acyl LPC by PLA2[7] (Saccharomyces cerevisiae)
REACT:R-SPO-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)
REACT:R-MMU-888577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of GABA by GAD2 (Mus musculus)
RHEA:50244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:47070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O => 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2
GO:0030759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylquercetagetin 6-O-methyltransferase activity
GO:0030759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-OMT
GO:0030759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 6-methyltransferase activity
GO:0030759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 6-O-methyltransferase activity
GO:0030759	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity
REACT:R-MMU-5690759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Mus musculus)
REACT:R-HSA-5693583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDC1 associates with gamma-H2AFX at nuclear foci (Homo sapiens)
GO:0015212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine transmembrane transporter activity
RHEA:24517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + gentamicin C1a => CoA + H(+) + N(2')-acetylgentamicin C1a
RHEA:19400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + CTP + L-cysteine <=> CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
GO:0004177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminopeptidase activity
REACT:R-RNO-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Rattus norvegicus)
RHEA:52741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyphosate + H2O + O2 => aminomethylphosphonate + glyoxylate + H(+) + H2O2
REACT:R-GGA-420123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like receptor 2 binds GLP2 (Gallus gallus)
RHEA:32957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O
GO:0030338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)
GO:0030338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-Neu5Ac hydroxylase activity
GO:0030338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity
GO:0030338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphoacetylneuraminate monooxygenase activity
GO:0030338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate hydroxylase activity
GO:0030338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminic monooxygenase activity
GO:0030338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetylneuraminic acid hydroxylase activity
GO:0030338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetylneuraminate monooxygenase activity
REACT:R-RNO-112385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides leads to transcript elongation (Rattus norvegicus)
REACT:R-DME-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Drosophila melanogaster)
REACT:R-RNO-6786070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Rattus norvegicus)
RHEA:71093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) => dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out)
GO:0033446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGC codon-amino acid adaptor activity
GO:0033446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine tRNA
REACT:R-CFA-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Canis familiaris)
REACT:R-DRE-6804955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDM2 (Danio rerio)
REACT:R-MMU-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Mus musculus)
REACT:R-BTA-444731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Bos taurus)
REACT:R-XTR-4546385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO2 (Xenopus tropicalis)
REACT:R-CFA-2029475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of AA by iPLA2 upon FCGR activation (Canis familiaris)
REACT:R-SSC-170120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25B to the cytoplasm (Sus scrofa)
REACT:R-RNO-1605717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Rattus norvegicus)
REACT:R-MMU-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Mus musculus)
GO:0018757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deisopropylhydroxyatrazine aminohydrolase activity
REACT:R-SSC-197271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)
RHEA:42864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermine + S-methyl-5'-thioadenosine
RHEA:42864	skos:prefLabel	"norspermine synthase"
RHEA:42864	skos:altLabel	"long-chain polyamine synthase"
RHEA:42864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"norspermine synthase"
REACT:R-CEL-5138441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A-FZD4 recruits DVL2 (Caenorhabditis elegans)
REACT:R-DRE-2168881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Truncated Alpha-1-Microglobulin binds heme (Danio rerio)
REACT:R-SSC-9731613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)
REACT:R-XTR-182969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:CBL) (Xenopus tropicalis)
REACT:R-CFA-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Canis familiaris)
GO:0031835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	substance P receptor binding
GO:0031835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurokinin-1 receptor binding
GO:0031835	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	substance P receptor ligand
GO:0102647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity
REACT:R-DRE-6785986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA nucleases unhook the interstrand crosslink (ICL) (Danio rerio)
REACT:R-DME-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Drosophila melanogaster)
RHEA:68246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + Na(+)(out) => L-phenylalanine(in) + Na(+)(in)
REACT:R-GGA-1358797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated RNF41 binds P-USP8 (Gallus gallus)
REACT:R-HSA-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Homo sapiens)
RHEA:65356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
GO:0102920	skos:prefLabel	"isopenicillin-N N-acyltransferase"
GO:0102920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl coenzyme A: isopenicillin N acyltransferase activity
GO:0102920	skos:altLabel	"acyl-coenzyme A:isopenicillin N acyltransferase"
GO:0102920	skos:altLabel	"acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase"
GO:0102920	skos:altLabel	"isopenicillin N:acyl-CoA acyltransferase"
GO:0102920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopenicillin N + phenylacetyl-CoA = CoA + H(+) + L-2-aminoadipate + penicillin G
GO:0102920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isopenicillin-N N-acyltransferase"
REACT:R-SSC-8949659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Sus scrofa)
RHEA:54792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[nsP1 protein]-L-histidine + N(7)-methyl-GTP = [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate
REACT:R-HSA-9029690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-6 translocates to the nucleus (Homo sapiens)
REACT:R-DME-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Drosophila melanogaster)
RHEA:65947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + CTP + S-adenosyl-L-methionine <=> 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine
RHEA:59162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]
REACT:R-SSC-6804527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INTL1 binds bacterial glycans (Sus scrofa)
REACT:R-RNO-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Rattus norvegicus)
RHEA:19383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + CO2 => (S)-oxalosuccinate + H(+)
RHEA:49899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate <=> 5,10-dihydrophenazine-1,6-dicarboxylate
REACT:R-HSA-110156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)
RHEA:18411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+)
REACT:R-RNO-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Rattus norvegicus)
EC:3.1.7.9	skos:prefLabel	"isotuberculosinol synthase"
EC:3.1.7.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isotuberculosinol synthase"
REACT:R-SSC-914036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)
RHEA:17437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dichloromuconate cycloisomerase"
RHEA:17437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate = (2E,4E)-2,4-dichloromuconate + H(+)
RHEA:17437	skos:prefLabel	"dichloromuconate cycloisomerase"
REACT:R-HSA-6805035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds STK11 and NUAK1 (Homo sapiens)
RHEA:15182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA(out) + ATP + H2O => ADP + an acyl-CoA(in) + H(+) + phosphate
GO:0047740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin C aminotransferase activity
GO:0047740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine:cephalosporin-C aminotransferase activity
GO:0047740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cephalosporin-C:2-oxoglutarate aminotransferase activity
GO:0047740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cephalosporin-C transaminase activity
REACT:R-CFA-977602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to MCP, CR1:C4b, C3b (Canis familiaris)
RHEA:61947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecholesterol + UDP-alpha-D-glucose <=> 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP
REACT:R-SSC-174916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of N-glucuronides (Sus scrofa)
RHEA:63103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + ilicicolin C + NADPH + O2 <=> ascochlorin + 2 H2O + NADP(+)
EC:7.2.2.21	skos:prefLabel	"Cd(2+)-exporting ATPase"
EC:7.2.2.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Cd(2+)-exporting ATPase"
EC:7.2.2.21	skos:altLabel	"cadmium-translocating P-type ATPase"
EC:7.2.2.21	skos:altLabel	"cadmium-exporting ATPase"
GO:0033438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACC codon-amino acid adaptor activity
GO:0033438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threonine tRNA
REACT:R-MMU-5673768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)
REACT:R-HSA-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
REACT:R-SSC-8875183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates activated MET (Sus scrofa)
REACT:R-HSA-8938063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 gene expression is inhibited by RUNX1:CBFB (Homo sapiens)
RHEA:71499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)
RHEA:26040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + GDP-alpha-D-mannose => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)
RHEA:42113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-hydroxypregn-4-en-3-one + NADP(+) => H(+) + NADPH + progesterone
GO:0036201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokaurene C2-hydroxylase activity
RHEA:44716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-4,4'-diapolycopen-4-al + H2O = AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)
REACT:R-DRE-8949649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Danio rerio)
REACT:R-HSA-2022911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSPG is secreted (Homo sapiens)
RHEA:39810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoate(in) <=> octadecanoate(out)
GO:0097245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavanol binding
GO:0097245	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	flavan-3-ol binding
GO:1903880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone binding
RHEA:46459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)
RHEA:32614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeranial + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH
RHEA:58724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine
REACT:R-MMU-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Mus musculus)
RHEA:41274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-MMU-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Mus musculus)
REACT:R-BTA-8848663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADIPOQ trimer binds ADIPOR dimers (Bos taurus)
REACT:R-XTR-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Xenopus tropicalis)
RHEA:46156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,9'-di-cis-phytofluene + a plastoquinone = 9,9',15-tri-cis-zeta-carotene + a plastoquinol
RHEA:41080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
GO:0033846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoride + S-adenosyl-L-methionine = 5'-deoxy-5'-fluoroadenosine + L-methionine
GO:0033846	skos:altLabel	"fluorinase"
GO:0033846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosyl-fluoride synthase activity
GO:0033846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:fluoride adenosyltransferase activity
GO:0033846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fluorinase activity
GO:0033846	skos:prefLabel	"adenosyl-fluoride synthase"
GO:0033846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosyl-fluoride synthase"
RHEA:19719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + CO2 => H(+) + L-phenylalanine
RHEA:57963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfide + H(+) + NADH + O2 <=> dimethyl sulfoxide + H2O + NAD(+)
RHEA:53497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate
RHEA:45180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (E)-4-coumaroyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine
RHEA:45180	skos:prefLabel	"spermidine dicoumaroyl transferase"
RHEA:45180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spermidine dicoumaroyl transferase"
RHEA:52036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate = L-isoleucine + tuberonate
RHEA:29792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(out) + H2O => ADP + glutathione(in) + H(+) + phosphate
REACT:R-XTR-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Xenopus tropicalis)
GO:0001565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phorbol ester receptor activity
RHEA:15974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + estrone => adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)
RHEA:71668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(out) + succinate(in) => malonate(in) + succinate(out)
RHEA:18467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2
REACT:R-HSA-8857555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates GPNMB (Homo sapiens)
REACT:R-SSC-376122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM/DSCAML1 homodimerization (Sus scrofa)
REACT:R-GGA-193669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to p75NTR:NRIF (Gallus gallus)
EC:3.4.21.118	skos:prefLabel	"kallikrein 8"
EC:3.4.21.118	skos:altLabel	"neuropsin"
EC:3.4.21.118	skos:altLabel	"ovasin"
EC:3.4.21.118	skos:altLabel	"TADG-14"
EC:3.4.21.118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kallikrein 8"
EC:3.4.21.118	skos:altLabel	"serine protease 19"
EC:3.4.21.118	skos:altLabel	"tumor-associated differentially expressed gene 14"
RHEA:72460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + L-aspartate(out) => fumarate(out) + L-aspartate(in)
REACT:R-MMU-8878581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYRP1 oxidises DHICA to IQCA (Mus musculus)
REACT:R-MMU-190385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3b (Mus musculus)
REACT:R-GGA-8874079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated MET (Gallus gallus)
REACT:R-MMU-9755303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades HIFalpha (Mus musculus)
REACT:R-XTR-1605632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Both hexosaminidase A and B can cleave GalNAc from globoside (Xenopus tropicalis)
REACT:R-HSA-8943728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 binds the PTEN gene promoter (Homo sapiens)
RHEA:46497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)
RHEA:51975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:14613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type taurine transporter"
RHEA:14613	skos:altLabel	"taurine-transporting ATPase"
RHEA:14613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurine(out) = ADP + H(+) + phosphate + taurine(in)
RHEA:14613	skos:altLabel	"taurine ABC transporter"
RHEA:14613	skos:prefLabel	"ABC-type taurine transporter"
RHEA:24624	skos:altLabel	"threonine translase"
RHEA:24624	skos:prefLabel	"threonine--tRNA ligase"
RHEA:24624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"threonine--tRNA ligase"
RHEA:24624	skos:altLabel	"threonyl-tRNA synthetase"
RHEA:24624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)
REACT:R-DME-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Drosophila melanogaster)
RHEA:53616	skos:prefLabel	"(+)-isoafricanol synthase"
RHEA:53616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-isoafricanol synthase"
RHEA:53616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate
RHEA:49160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9701531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727 STAT3 is acetylated (Homo sapiens)
REACT:R-HSA-174739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant + apoE => chylomicron remnant:apoE complex (Homo sapiens)
REACT:R-HSA-9023626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
REACT:R-CFA-8847638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Canis familiaris)
RHEA:24158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl phosphate + ADP => 2-methylpropanoate + ATP
RHEA:17626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysopine + H2O + NADP(+) => H(+) + L-lysine + NADPH + pyruvate
REACT:R-MMU-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Mus musculus)
RHEA:24319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> (+)-copalyl diphosphate
RHEA:19172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine <=> NH4(+) + pyruvate
REACT:R-SSC-196950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTRAP hydrolyzes FMN to RIB (Sus scrofa)
REACT:R-DRE-73666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O => dUMP + pyrophosphate (Danio rerio)
REACT:R-HSA-444191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR120 is a receptor for unsaturated long-chain free fatty acids (Homo sapiens)
REACT:R-SSC-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Sus scrofa)
REACT:R-DRE-8950179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B translocates from the cytosol to the extracellular region (Danio rerio)
RHEA:28501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + mycothiol <=> S-(hydroxymethyl)mycothiol
REACT:R-XTR-5634100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 dissociates from RXRA:PPARD:atRA (Xenopus tropicalis)
RHEA:48056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = beta-D-glucosylceramide + D-galactose
RHEA:12749	skos:prefLabel	"gallate decarboxylase"
RHEA:12749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate + H(+) = 1,2,3-trihydroxybenzene + CO2
RHEA:12749	skos:altLabel	"gallate carboxy-lyase"
RHEA:12749	skos:altLabel	"gallic acid decarboxylase"
RHEA:12749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gallate decarboxylase"
RHEA:47555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate + H2O <=> deoxycholate + glycine
REACT:R-RNO-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Rattus norvegicus)
RHEA:68646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-thujene + diphosphate => (2E)-geranyl diphosphate
RHEA:48361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-saturated fatty acid + H2O2 => a 2-hydroxy fatty acid + H2O
REACT:R-BTA-3900070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MKL1 with SUMO1 (Bos taurus)
RHEA:16160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[leghemoglobin] + NADPH <=> 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)
RHEA:61363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + pheophorbide a(in) <=> ADP + H(+) + pheophorbide a(out) + phosphate
EC:3.4.21.106	skos:prefLabel	"hepsin"
EC:3.4.21.106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hepsin"
REACT:R-SPO-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Schizosaccharomyces pombe)
REACT:R-HSA-8854645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)
GO:0050553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)
GO:0050553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxa-4(5),11(12)-diene synthase activity
GO:0050553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxadiene synthase activity
GO:0050553	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)
RHEA:49081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5-oxide + FMNH2 + O2 => dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O
RHEA:52053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-hexadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + hexadecanoate
REACT:R-PFA-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Plasmodium falciparum)
REACT:R-DDI-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Dictyostelium discoideum)
REACT:R-RNO-68918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK and DDK associate with the Mcm10:pre-replicative complex (Rattus norvegicus)
REACT:R-XTR-1112565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Xenopus tropicalis)
RHEA:67271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate <=> sch 210972
RHEA:58812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate = AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
RHEA:58812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase"
RHEA:58812	skos:altLabel	"UDP-MurNAc-L-Ala-L-Glu epimerase"
RHEA:58812	skos:prefLabel	"UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase"
REACT:R-XTR-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Xenopus tropicalis)
RHEA:40182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + O2 <=> (2E)-decenoyl-CoA + H2O2
RHEA:34600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine + NADP(+) => 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH
REACT:R-MMU-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Mus musculus)
REACT:R-SSC-182594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of INK4 family proteins with CDK4/6 (Sus scrofa)
RHEA:60790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A9 + H2O => gibberellin A24 + H(+) + O2
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminyltransferase I activity
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GnTI
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GNTI activity
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
GO:0003827	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity
REACT:R-GGA-141139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of TRAIL:TRAIL receptor complex (Gallus gallus)
REACT:R-MMU-177920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2 to GAB1 (Mus musculus)
REACT:R-SSC-1655842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1P hydrolyzes SREBP1A,1C,2 (Sus scrofa)
REACT:R-RNO-4420121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate PLCG1 (Rattus norvegicus)
REACT:R-SSC-8934446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC phosphorylates SHC1 (Sus scrofa)
REACT:R-CFA-5340226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB dioxygenates NO (Canis familiaris)
REACT:R-HSA-2396561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)
REACT:R-HSA-112379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of elongation factors to form elongation complex (Homo sapiens)
RHEA:54260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparaginyl-[protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate
REACT:R-RNO-5218891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1:RIPK3 oligomer binds MLKL (Rattus norvegicus)
REACT:R-DRE-9023884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to TGFA promoter (Danio rerio)
RHEA:32503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-167481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of HIV-1 elongation after arrest (Homo sapiens)
RHEA:16895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylpyridinium + S-adenosyl-L-homocysteine => pyridine + S-adenosyl-L-methionine
REACT:R-MMU-1592398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP8 (Mus musculus)
REACT:R-HSA-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Homo sapiens)
RHEA:61918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + fluconazole(out) + H(+) + phosphate => ATP + fluconazole(in) + H2O
GO:0035473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipase binding
REACT:R-RNO-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Rattus norvegicus)
RHEA:56703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate
RHEA:72974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline(out) + 2 Na(+)(out) <=> 5-oxo-L-proline(in) + 2 Na(+)(in)
RHEA:14751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+) => 1-hydroxy-2-naphthoate + O2
REACT:R-HSA-165047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
RHEA:15500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate <=> 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine
REACT:R-HSA-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Homo sapiens)
REACT:R-SSC-174367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCL ligates L-Glu to L-Cys (Sus scrofa)
REACT:R-HSA-9620828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,(FOXO4) binds CCNG2 gene promoter (Homo sapiens)
REACT:R-HSA-5663258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors (Homo sapiens)
RHEA:43279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GalNAc-GD1a + H(+) + UDP
RHEA:13723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + testolate => H2O + testololactone
REACT:R-HSA-6791306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates AIFM2 gene expression (Homo sapiens)
REACT:R-BTA-5690702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN phosphorylates CD22 (Bos taurus)
REACT:R-HSA-202718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Homo sapiens)
RHEA:27661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-alpha-D-ribose 1-phosphate <=> 2-deoxy-D-ribose 5-phosphate
REACT:R-SSC-936951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to activated TLR4 complex (Sus scrofa)
RHEA:11808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bergaptol + S-adenosyl-L-methionine = bergapten + S-adenosyl-L-homocysteine
REACT:R-RNO-9014454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG translocates to the ER membrane (Rattus norvegicus)
REACT:R-HSA-8950681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Lamin-B1 (Homo sapiens)
REACT:R-GGA-6797803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds SLITRK1-6 (Gallus gallus)
RHEA:20670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
REACT:R-DRE-70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Danio rerio)
GO:0051022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rho GDI binding
GO:0051022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rho GDP-dissociation inhibitor binding
REACT:R-MMU-9705713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 dehydrogenates TEST to DHTEST (Mus musculus)
RHEA:44829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + decanoyl-CoA => CoA + O-decanoyl-(R)-carnitine
RHEA:16801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-tyrosine sulfotransferase"
RHEA:16801	skos:altLabel	"tyrosylprotein sulfotransferase"
RHEA:16801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]
RHEA:16801	skos:prefLabel	"protein-tyrosine sulfotransferase"
REACT:R-BTA-9007283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 and PRC1.6 associate with E2F6.com-1 (Bos taurus)
RHEA:44645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)
RHEA:27968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate + H2O
REACT:R-MMU-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Mus musculus)
RHEA:61657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + ATP => (2E,6E)-farnesyl phosphate + ADP + H(+)
RHEA:65417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP(in) + NAD(+)(out) => dGMP(out) + NAD(+)(in)
RHEA:10645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-2H-pyran-4,6-dicarboxylate + H2O => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)
GO:0031072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heat shock protein binding
REACT:R-CFA-450133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)
REACT:R-HSA-192925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Export of Spliced Viral mRNA (Homo sapiens)
REACT:R-SSC-1236967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alkalization of the phagosomal lumen by NOX2 (Sus scrofa)
RHEA:51922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a quinol => a quinone + AH2
RHEA:55295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(54) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine
RHEA:66583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + bisphenol A <=> adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)
RHEA:47999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)
REACT:R-BTA-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Bos taurus)
REACT:R-HSA-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Homo sapiens)
REACT:R-CFA-1250315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB4 homodimers (Canis familiaris)
GO:0047765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caldesmon-phosphate phosphohydrolase activity
GO:0047765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	smooth muscle caldesmon phosphatase activity
GO:0047765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caldesmon-phosphatase activity
GO:0047765	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SMP-I
RHEA:54523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> cycloaraneosene + diphosphate
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cellobiase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucoside glucohydrolase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	quercetin 3'-O-beta-D-glucopyranoside hydrolase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-glucoside glucohydrolase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	amygdalinase
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentiobiase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytokine beta-glucosidase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	elaterase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	quercetin 4'-O-beta-D-glucopyranoside hydrolase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	primeverosidase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,6-glucosidase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	arbutinase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	limarase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	emulsin
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-beta-glucosidase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosidase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucosidase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	amygdalase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-nitrophenyl beta-glucosidase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	salicilinase activity
GO:0008422	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentobiase activity
RHEA:71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(in) + chloride(in) + 2 Na(+)(in) => beta-alanine(out) + chloride(out) + 2 Na(+)(out)
RHEA:14571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propanal => propane-1,2-diol
REACT:R-RNO-1497869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Salvage - Sepiapterin is reduced to BH2 (Rattus norvegicus)
REACT:R-SSC-3225851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin and activate MAP3K5 (Sus scrofa)
REACT:R-MMU-2172666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds condensin II (Mus musculus)
RHEA:72514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + 2-oxoglutarate(in) <=> (R)-carnitine(in) + 2-oxoglutarate(out)
REACT:R-BTA-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Bos taurus)
REACT:R-MMU-9733960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids dissociate from ALB (Mus musculus)
RHEA:58541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-dodecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine
REACT:R-RNO-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)
GO:0016682	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	laccase activity
GO:0016682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO:0016682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With oxygen as acceptor"
GO:0016682	skos:prefLabel	"With oxygen as acceptor"
REACT:R-DME-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
REACT:R-BTA-173545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Bos taurus)
GO:0052791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity
GO:0052791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-keto-3-deoxynononic acid sialidase activity
RHEA:26411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-muramate 6-phosphate => (R)-lactate + N-acetyl-D-glucosamine 6-phosphate
RHEA:45069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + an acyl-CoA => CoA + O-acyl-(R)-carnitine
REACT:R-HSA-5693599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)
GO:0052904	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N(1)-acetylpolyamine oxidase activity
GO:0052904	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	non-specific polyamine oxidase activity
GO:0052904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052904	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyamine oxidase activity
REACT:R-GGA-5696664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 or PARP2 binds DDB2 at GG-NER site (Gallus gallus)
REACT:R-HSA-8865505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (Homo sapiens)
RHEA:61228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidine + O2 = 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)
REACT:R-DDI-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)
RHEA:11642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH => a (2R,3R)-flavan-3-ol + 2 NAD(+)
REACT:R-SSC-109536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)
REACT:R-HSA-5666216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds TAX1BP3 (Homo sapiens)
RHEA:17083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol => S-adenosyl-L-methionine + trans-isoeugenol
RHEA:71903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide
GO:0102947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-delta-cadinene-8-hydroxylase activity
GO:0042287	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	major histocompatibility complex ligand
GO:0042287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC protein binding
GO:0042287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	major histocompatibility complex binding
RHEA:13685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol + NADP(+) = 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH
RHEA:13788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA <=> H2O + itaconyl-CoA
REACT:R-RNO-9679477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFA inhibitors (Rattus norvegicus)
RHEA:52230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + biliverdin beta + CO + Fe(2+) + 3 H2O => 3 AH2 + 2 H(+) + heme b + 3 O2
RHEA:28436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP] => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP]
REACT:R-HSA-448427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 binds Interleukin-27 receptor (Homo sapiens)
RHEA:18484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexylsulfamate + H2O <=> cyclohexylamine + sulfate
REACT:R-BTA-139919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BIM to mitochondria (Bos taurus)
REACT:R-SSC-9028730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NTRK2 binds FRS2 (Sus scrofa)
REACT:R-BTA-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Bos taurus)
RHEA:48080	skos:prefLabel	"ferruginol synthase"
RHEA:48080	skos:altLabel	"miltiradiene oxidase"
RHEA:48080	skos:altLabel	"CYP76AH1"
RHEA:48080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferruginol synthase"
RHEA:48080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] = ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:10711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glucose
REACT:R-SPO-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)
REACT:R-GGA-202174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ZAP-70 (Gallus gallus)
REACT:R-HSA-9031884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPAn-6 SPMs translocate from cytosol to extracellular region (Homo sapiens)
RHEA:46434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:50947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate + NAD(+) <=> (E)-cinnamate + H(+) + NADH
REACT:R-SSC-5679041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2 transports BMG,BDG from cytosol to extracellular region (Sus scrofa)
REACT:R-HSA-9008215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds GLI3R (Homo sapiens)
REACT:R-MMU-201628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at DSVD (85) (Mus musculus)
RHEA:67017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]
REACT:R-GGA-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Gallus gallus)
RHEA:46290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-HSA-392053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS binds Grb2 bound to pFAK:NCAM1 (Homo sapiens)
RHEA:69946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol
REACT:R-BTA-4551727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Bos taurus)
REACT:R-RNO-165179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TSC1:TSC2 complex (Rattus norvegicus)
REACT:R-XTR-9027607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Xenopus tropicalis)
RHEA:52440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)
RHEA:52440	skos:altLabel	"guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase"
RHEA:52440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)
RHEA:52440	skos:prefLabel	"phosphatidyl-myo-inositol dimannoside synthase"
RHEA:52440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidyl-myo-inositol dimannoside synthase"
GO:0102769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide glucosyltransferase activity
RHEA:49186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol => chlorophyllide a + H(+) + H2O
RHEA:65107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene D + L-prolyl-[peptidyl-carrier protein] <=> aculene B + holo-[peptidyl-carrier protein]
RHEA:51591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopyridoxal + NAD(+) <=> 5-pyridoxolactone + H(+) + NADH
REACT:R-RNO-3788748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL6 promoter (Rattus norvegicus)
RHEA:38021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-decanoylglycerol
REACT:R-CFA-9011748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9R binds JAK1 (Canis familiaris)
REACT:R-RNO-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Rattus norvegicus)
RHEA:25897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonate => acetate + CO2
GO:0070643	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	calciferol 25-hydroxylase activity
GO:0070643	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vitamin D2 25-hydroxylase activity
GO:0070643	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cholecalciferol 25-hydroxylase activity
GO:0070643	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ergocalciferol 25-hydroxylase activity
GO:0070643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin D 25-hydroxylase activity
REACT:R-RNO-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Rattus norvegicus)
RHEA:59886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chloro-L-lysine + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-lysine + O2
RHEA:61204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal = H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]
RHEA:49837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5E)-tetradecenoyl-CoA + (R)-carnitine => (5E)-tetradecenoyl-(R)-carnitine + CoA
RHEA:30018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
REACT:R-MMU-9707353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 binds Aromatase inhibitors (Mus musculus)
REACT:R-HSA-2187330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
RHEA:35238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + tetracycline(in) <=> H(+)(in) + tetracycline(out)
GO:0036174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butane monooxygenase activity
GO:0036174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sBMO
GO:0036174	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	soluble butane monooxygenase
REACT:R-DRE-9626816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds p-S345-NCF1 (Danio rerio)
REACT:R-MMU-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Mus musculus)
REACT:R-RNO-1236943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigen peptide onto MHC class I molecule (Rattus norvegicus)
RHEA:62318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-salicyl-beta-D-glucose + UDP => salicylate + UDP-alpha-D-glucose
REACT:R-HSA-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Homo sapiens)
REACT:R-HSA-9737046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate binds GRM4 (mGluR4) (Homo sapiens)
REACT:R-SSC-6813659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE, CTSG or PRTN3 binds bacteria (Sus scrofa)
RHEA:49402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + validoxylamine A => H2O + validoxylamine A 7'-phosphate
REACT:R-RNO-1483159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho is dephosphorylated to Cho by PHOSPHO1 (Rattus norvegicus)
RHEA:32463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine/sarcosine N-methyltransferase"
RHEA:32463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + 2 S-adenosyl-L-methionine = 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine
RHEA:32463	skos:altLabel	"GMT"
RHEA:32463	skos:altLabel	"GSMT"
RHEA:32463	skos:altLabel	"glycine sarcosine N-methyltransferase"
RHEA:32463	skos:altLabel	"glycine-sarcosine methyltransferase"
RHEA:32463	skos:prefLabel	"glycine/sarcosine N-methyltransferase"
REACT:R-SSC-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)
REACT:R-CEL-189069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose + H2O => glucose + fructose (Caenorhabditis elegans)
REACT:R-DME-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Drosophila melanogaster)
RHEA:36892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O
RHEA:14208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine + S-adenosyl-L-methionine <=> anserine + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)
RHEA:71441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa(in) + L-phenylalanine(out) => L-dopa(out) + L-phenylalanine(in)
REACT:R-DDI-8876191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 GEFs exchange GTP for GDP on RAB9 (Dictyostelium discoideum)
RHEA:59485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite + 2 Fe(III)-[cytochrome c] + H2O => arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)
REACT:R-GGA-450550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCalpha phosphorylates HuR (Gallus gallus)
RHEA:53451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate
RHEA:48302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha 1-glyceryl ester
RHEA:45727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl alcohol + NADP(+) <=> (E)-4-coumaraldehyde + H(+) + NADPH
REACT:R-MMU-9021596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane estrogen receptors bind SRC (Mus musculus)
REACT:R-XTR-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Xenopus tropicalis)
RHEA:36503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA
REACT:R-RNO-193961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Rattus norvegicus)
RHEA:19666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-CoA + NAD(+) => 6-carboxyhex-2-enoyl-CoA + H(+) + NADH
REACT:R-HSA-4332363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation and activation of CAMK2 (Homo sapiens)
RHEA:66156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + tyramine = CoA + H(+) + N-butanoyltyramine
REACT:R-HSA-168849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAX protein (Homo sapiens)
RHEA:23071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA <=> 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)
RHEA:14987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:51657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagaturonate => keto-D-fructuronate
RHEA:36916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA
GO:0072374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carotene epsilon hydroxylase activity
REACT:R-HSA-5654658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS bind to PPTN11 (Homo sapiens)
REACT:R-SSC-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Sus scrofa)
RHEA:46122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DDI-9668335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds LEMD2 (Dictyostelium discoideum)
REACT:R-DRE-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Danio rerio)
REACT:R-SSC-202212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to LAT (Sus scrofa)
REACT:R-MMU-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Mus musculus)
REACT:R-MMU-1614583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K212-CTH cleaves L-Cystathionine (Mus musculus)
REACT:R-GGA-3788708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)
REACT:R-GGA-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Gallus gallus)
GO:0043532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiostatin binding
REACT:R-DME-372705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of BCAR1 to PTK2 complex (Drosophila melanogaster)
REACT:R-XTR-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Xenopus tropicalis)
RHEA:63274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2
REACT:R-SPO-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Schizosaccharomyces pombe)
RHEA:67889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine => 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)
GO:0034008	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity
GO:0034008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	R-linalool synthase activity
GO:0034008	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-3R-linalool synthase activity
GO:0034008	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-linalool synthase activity
RHEA:71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hispidin + NADH + O2 <=> 3-hydroxyhispidin + H2O + NAD(+)
REACT:R-RNO-5694109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer hydrolyses TAG to DAG and FA (Rattus norvegicus)
REACT:R-SCE-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Saccharomyces cerevisiae)
RHEA:43209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine => 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine
RHEA:42460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzofuran + H(+) + NADH + O2 = biphenyl-2,2',3-triol + NAD(+)
REACT:R-DRE-5690157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP16,USP21 deubiquitinate Histone H2A (Danio rerio)
RHEA:45186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+)
RHEA:20191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + uracil => 5,6-dihydrouracil + NAD(+)
RHEA:68157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + L-glutamate => diphosphate + N-geranyl-L-glutamate
RHEA:68901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxybenzoate + ATP + H(+) + NADPH => 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)
REACT:R-GGA-1112727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serine phosphorylation of STATs (Gallus gallus)
REACT:R-SSC-2187309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)
REACT:R-SCE-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Saccharomyces cerevisiae)
REACT:R-XTR-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Xenopus tropicalis)
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphonate-transporting ATPase activity
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP phosphohydrolase (phosphonate-transporting)
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alkylphosphonate transmembrane-transporting ATPase activity
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	organic phosphonate transmembrane transporter activity
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATPase-coupled alkylphosphonate transmembrane transporter activity
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alkylphosphonate transmembrane transporter activity
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled organic phosphonate transmembrane transporter activity
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphonate ABC transporter
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	organic phosphonate transmembrane-transporting ATPase activity
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alkylphosphonate ABC transporter activity
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type phosphonate transporter activity
GO:0015416	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphonate transporting ATPase activity
RHEA:41682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-all-trans-polyprenylphenol + CO2 => a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+)
REACT:R-DME-8849882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-4 bind reticulon 3 (Drosophila melanogaster)
REACT:R-BTA-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Bos taurus)
RHEA:12088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP
RHEA:12088	skos:altLabel	"UDP-glucose-ceramide glucosyltransferase"
RHEA:12088	skos:altLabel	"glucosylceramide synthase"
RHEA:12088	skos:prefLabel	"ceramide glucosyltransferase"
RHEA:12088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ceramide glucosyltransferase"
REACT:R-DDI-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Dictyostelium discoideum)
RHEA:66505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:60264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(4) N-methyltransferase"
RHEA:60264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:60264	skos:prefLabel	"[histone H3]-lysine(4) N-methyltransferase"
REACT:R-RNO-432237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Rattus norvegicus)
REACT:R-BTA-904830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
RHEA:31259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	but-3-ynal + H2O + NAD(+) = 3-butynoate + 2 H(+) + NADH
REACT:R-PFA-8851494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase7 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
RHEA:66746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartate(in)
RHEA:50188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine
REACT:R-MMU-3858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL recruits RAC (Mus musculus)
RHEA:37041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2
REACT:R-HSA-2404131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
REACT:R-RNO-4086036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate NRIP1 with SUMO1 (Rattus norvegicus)
REACT:R-HSA-6798489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A7 or S100A7A binds Zn2+ (Homo sapiens)
RHEA:67059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chermesin D + S-adenosyl-L-methionine <=> chermesin D methyl ester + S-adenosyl-L-homocysteine
RHEA:42273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA
REACT:R-CFA-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Canis familiaris)
EC:3.1.3.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sugar-phosphatase"
EC:3.1.3.23	skos:prefLabel	"sugar-phosphatase"
EC:3.4.21.68	skos:altLabel	"tissue-type plasminogen activator"
EC:3.4.21.68	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"t-plasminogen activator"
EC:3.4.21.68	skos:altLabel	"tPA"
EC:3.4.21.68	skos:prefLabel	"t-plasminogen activator"
EC:3.4.21.68	skos:altLabel	"tissue plasminogen activator"
RHEA:36022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-RNO-982792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor binds JAK2 (Rattus norvegicus)
REACT:R-XTR-9627056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procaspase 9 forms dimer (Xenopus tropicalis)
RHEA:66644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = diphosphate + trichobrasilenol
REACT:R-GGA-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Gallus gallus)
RHEA:71440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa(out) + L-phenylalanine(in) => L-dopa(in) + L-phenylalanine(out)
REACT:R-DRE-372529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of acetylcholine at the synapse (Danio rerio)
REACT:R-GGA-5218809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Gallus gallus)
RHEA:11758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein] => ATP + biotin + L-lysyl-[protein]
REACT:R-SPO-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)
RHEA:64852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + octan-1-ol = CoA + octyl benzoate
REACT:R-SSC-5690843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Sus scrofa)
RHEA:17271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + tylosin => macrocin + S-adenosyl-L-methionine
REACT:R-XTR-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Xenopus tropicalis)
REACT:R-CFA-8849157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Canis familiaris)
RHEA:48264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] = H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate
REACT:R-RNO-5691507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPA deacetylates NAA to acetate and L-aspartate (Rattus norvegicus)
REACT:R-MMU-76434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of carbon tetrachloride to form a free radical (Mus musculus)
RHEA:27574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-piperidine-3-carboxamide + H2O = (3R)-piperidine-3-carboxylate + NH4(+)
RHEA:58515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)
GO:1990576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled glucose receptor activity
GO:1990576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled glucose receptor activity
RHEA:62995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecamide <=> NH4(+) + tetradecanoate
RHEA:66173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-cystine(out) => H(+)(in) + L-cystine(in)
RHEA:36105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-methyl anthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine
RHEA:55120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)
RHEA:27927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMP(in) => UMP(out)
REACT:R-HSA-418442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Homo sapiens)
RHEA:23053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]
RHEA:38152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonyl sulfide + H2O => CO2 + H(+) + hydrogen sulfide
RHEA:53613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + D-ribulose 5-phosphate + H(+) => CDP-D-ribulose + diphosphate
RHEA:63336	skos:altLabel	"mutarotase"
RHEA:63336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldose 1-epimerase"
RHEA:63336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xylose = beta-D-xylose
RHEA:63336	skos:altLabel	"aldose mutarotase"
RHEA:63336	skos:prefLabel	"aldose 1-epimerase"
REACT:R-BTA-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Bos taurus)
RHEA:48685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine
REACT:R-DRE-5423653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGST trimers transfer GS from GSH to AFXBO and AFNBO (Danio rerio)
RHEA:40778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-phenylacetonitrile + H(+) + 2 H2O <=> D-alpha-phenylglycine + NH4(+)
REACT:R-MMU-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Mus musculus)
RHEA:16612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + adenine
REACT:R-RNO-1638821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
REACT:R-GGA-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Gallus gallus)
RHEA:68474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-alpha-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate
GO:0052918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
REACT:R-BTA-8940998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36RN, IL1F10 bind IL1RL2 (Bos taurus)
REACT:R-CEL-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Caenorhabditis elegans)
RHEA:19754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + diphthine-[translation elongation factor 2] + NH4(+) => AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)
REACT:R-RNO-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Rattus norvegicus)
GO:0080073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine:coumaroyl CoA N-acyltransferase activity
REACT:R-MMU-174097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdh1 (Mus musculus)
RHEA:25216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP
RHEA:68633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Danio rerio)
REACT:R-CFA-6793661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Canis familiaris)
REACT:R-DME-198870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-SSC-5621363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Sus scrofa)
REACT:R-HSA-4088218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetrastatin binds integrin alphaVbeta3 (Homo sapiens)
RHEA:21952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-pregnane-3,20-dione + NADP(+) = H(+) + NADPH + progesterone
RHEA:17102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-acyl-(R)-carnitine => (R)-carnitine + a fatty acid + H(+)
GO:0010857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent protein kinase activity
RHEA:33987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate = diphosphate + neoabietadiene
RHEA:33987	skos:prefLabel	"neoabietadiene synthase"
RHEA:33987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neoabietadiene synthase"
REACT:R-MMU-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Mus musculus)
REACT:R-HSA-198298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT translocates to the nucleus (Homo sapiens)
REACT:R-RNO-266299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds membrane-associated free cholesterol and phospholipids (Rattus norvegicus)
REACT:R-BTA-8854044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)
REACT:R-BTA-177926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of PAG by SHP2 (Bos taurus)
GO:0000179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyladenosine transferase activity
GO:0000179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0000179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 (Homo sapiens)
GO:0000179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 (Homo sapiens)
GO:0000179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18S rRNA dimethylase activity
GO:0000179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity
REACT:R-DDI-428259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Dictyostelium discoideum)
REACT:R-BTA-451634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Bos taurus)
REACT:R-HSA-9700156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK dimer binds IRS1 (Homo sapiens)
RHEA:53215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
EC:1.12.1.2	skos:altLabel	"bidirectional hydrogenase"
EC:1.12.1.2	skos:altLabel	"H2:NAD(+) oxidoreductase"
EC:1.12.1.2	skos:altLabel	"NAD-linked hydrogenase"
EC:1.12.1.2	skos:altLabel	"hydrogenase"
EC:1.12.1.2	skos:prefLabel	"hydrogen dehydrogenase"
EC:1.12.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydrogen dehydrogenase"
REACT:R-MMU-1602398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Mus musculus)
RHEA:55161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:31755	skos:prefLabel	"oxepin-CoA hydrolase"
RHEA:31755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxepin-CoA hydrolase"
RHEA:31755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde
REACT:R-RNO-8848596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds PXN (Rattus norvegicus)
REACT:R-XTR-202726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F11R dimerises (Xenopus tropicalis)
RHEA:12571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + H(+) + NADH + O2 <=> 4-nitrocatechol + H2O + NAD(+)
REACT:R-CFA-194632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Canis familiaris)
GO:0031862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostanoid receptor binding
GO:0031862	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	prostanoid receptor ligand
RHEA:22047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+)(in) + H2O + K(+)(out) <=> ADP + 2 H(+)(out) + K(+)(in) + phosphate
RHEA:57622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:33842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) <=> 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate
RHEA:63541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neurotensin => L-leucine + neurotensin-(1-12)
REACT:R-RNO-1237325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A is protonated and carbamated causing release of oxygen (Rattus norvegicus)
RHEA:53420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine = H(+) + roseoflavin + S-adenosyl-L-homocysteine
REACT:R-SCE-9020258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Saccharomyces cerevisiae)
REACT:R-RNO-2395322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyridinoline cross-links (Rattus norvegicus)
RHEA:37321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycyl-L-methionine(in) + H(+) + phosphate => ATP + glycyl-L-methionine(out) + H2O
EC:3.1.3.33	skos:altLabel	"Polynucleotide 5'-triphosphatase"
EC:3.1.3.33	skos:prefLabel	"polynucleotide 5'-phosphatase"
EC:3.1.3.33	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polynucleotide 5'-phosphatase"
EC:3.1.3.33	skos:altLabel	"5'-polynucleotidase"
REACT:R-DRE-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Danio rerio)
RHEA:15801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
REACT:R-MMU-420724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds Ca2+ (Mus musculus)
REACT:R-BTA-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Bos taurus)
RHEA:56968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + pyruvate = dCDP + H(+) + phosphoenolpyruvate
RHEA:54791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide
GO:0016799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hydrolyzing N-glycosyl compounds"
GO:0016799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016799	skos:prefLabel	"Hydrolyzing N-glycosyl compounds"
REACT:R-BTA-5662466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLB phosphorylates D-xylulose (Bos taurus)
REACT:R-RNO-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Rattus norvegicus)
REACT:R-MMU-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Mus musculus)
GO:1904855	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PA700 proteasome activator binding
GO:1904855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA700-dependent proteasome activator binding
GO:1904855	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	modulator complex binding
GO:1904855	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	19S regulatory particle binding
GO:1904855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteasome regulatory particle binding
GO:0015488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronide:monovalent cation symporter activity
GO:0015488	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucuronoside permease activity
GO:0015488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronide:cation symporter activity
REACT:R-GGA-8987129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Gallus gallus)
RHEA:47437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z)-hexadecadienoyl-CoA + H2O => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA
RHEA:45343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O <=> (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)
RHEA:12993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohex-1-ene-1-carbonyl-CoA dehydrogenase"
RHEA:12993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:12993	skos:prefLabel	"cyclohex-1-ene-1-carbonyl-CoA dehydrogenase"
REACT:R-BTA-8939706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) polyubiquitinates RUNX2 (Bos taurus)
RHEA:19137	skos:prefLabel	"estradiol 6beta-monooxygenase"
RHEA:19137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A + H2O
RHEA:19137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"estradiol 6beta-monooxygenase"
RHEA:19137	skos:altLabel	"estradiol 6beta-hydroxylase"
GO:0000908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine dioxygenase activity
GO:0000908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-ketoglutarate-dependent taurine dioxygenase activity
GO:0000908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminoethanesulfonate dioxygenase activity
GO:0000908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)
REACT:R-CEL-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Caenorhabditis elegans)
RHEA:41131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-decanoyl-sn-glycero-3-phosphocholine + H2O = 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)
GO:0102369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11alpha-30-dihydroxy beta-amyrin dehydrogenase activity
RHEA:18099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + xanthine-8-carboxylate => pteridine-2,4,6,7-tetrol
RHEA:45307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine
RHEA:65895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate <=> H2O + xanthurenate
GO:0001046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	core promoter sequence-specific DNA binding
GO:0001046	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	core promoter binding
GO:0001046	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	eubacterial-type RNA polymerase core promoter sequence-specific DNA binding
GO:0001046	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial-type RNA polymerase core promoter sequence-specific DNA binding
RHEA:29388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H2O => CDP + H(+) + phosphate
RHEA:11032	skos:prefLabel	"chloromuconate cycloisomerase"
RHEA:11032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chloromuconate cycloisomerase"
RHEA:11032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate + H(+)
RHEA:11032	skos:altLabel	"muconate cycloisomerase II"
RHEA:60840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]
RHEA:18750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + NAD(+) => [protein]-disulfide + H(+) + NADH
RHEA:36679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-alpha-D-allose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH
REACT:R-CFA-1112602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Canis familiaris)
REACT:R-SPO-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Schizosaccharomyces pombe)
REACT:R-HSA-193655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myelin components can interact with p75NTR:NgR:LINGO1 (Homo sapiens)
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine-phosphate pyrophosphorylase activity
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TMP pyrophosphorylase activity
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TMP-PPase activity
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine phosphate pyrophosphorylase activity
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine-phosphate synthase activity
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiamine monophosphate pyrophosphorylase activity
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin-phosphate pyrophosphorylase activity
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamin-phosphate diphosphorylase activity
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TMP diphosphorylase activity
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine-phosphate diphosphorylase activity
GO:0004789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity
RHEA:30468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => (+)-endo-beta-bergamotene + diphosphate
REACT:R-BTA-2484822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore assembly (Bos taurus)
RHEA:46734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,6)-dimethylheptanoyl-CoA => (2R,6)-dimethylheptanoyl-CoA
RHEA:72554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + urate(in) <=> glutarate(in) + urate(out)
REACT:R-GGA-265424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Gallus gallus)
REACT:R-DDI-8865107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MICAL1 produces NADP+, H2O2 (Dictyostelium discoideum)
REACT:R-DME-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Drosophila melanogaster)
RHEA:54841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + octan-3-one => H2O + NADP(+) + pentyl propanoate
REACT:R-MMU-8854759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D14 binds RAB11 and ULK1 (Mus musculus)
REACT:R-DDI-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Dictyostelium discoideum)
REACT:R-CFA-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Canis familiaris)
RHEA:10917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate => all-trans-phytoene + diphosphate
RHEA:12413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + H2O => (R)-glycerate + phosphate
RHEA:42583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine + tRNA(Sec) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)
RHEA:54637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-yl diphosphate => diphosphate + labda-7,13(16),14-triene
GO:0046575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnogalacturonan acetylesterase activity
RHEA:38840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
RHEA:71640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K(+)(in) + Na(+)(in) => K(+)(out) + Na(+)(out)
REACT:R-RNO-1483186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is converted to PS by PTDSS1 (Rattus norvegicus)
RHEA:38546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] <=> (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]
REACT:R-DRE-9678766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 binds CYP3A4 inhibitors (Danio rerio)
REACT:R-GGA-3640872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP34 deubiquitinates AXIN1,AXIN2 (Gallus gallus)
REACT:R-DME-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Drosophila melanogaster)
RHEA:38929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O
REACT:R-MMU-8875183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates activated MET (Mus musculus)
REACT:R-SSC-9020273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Sus scrofa)
REACT:R-SSC-380311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Plk1 to centrosomes (Sus scrofa)
REACT:R-HSA-1169397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)
RHEA:43379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyinosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
REACT:R-HSA-9619214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK binds activated calmodulin in the cytosol (Homo sapiens)
REACT:R-SSC-8941234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Sus scrofa)
RHEA:44307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
GO:0102391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate
GO:0102391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoate-CoA ligase activity
REACT:R-XTR-5654692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
REACT:R-MMU-9733973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts bind FABP6 (Mus musculus)
REACT:R-HSA-3296233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T2Rs bind bitter-tasting compounds (Homo sapiens)
RHEA:10821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate => D-erythro-isocitrate
GO:0005550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pheromone binding
REACT:R-HSA-6797293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of IL18, ALOX5 (Homo sapiens)
REACT:R-PFA-1676024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Plasmodium falciparum)
RHEA:28344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + diphosphate + H(+) => dITP + H2O
GO:0018474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxybenzaldehyde dehydrogenase activity
RHEA:36398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + NADP(+) <=> 7-dehydrodesmosterol + H(+) + NADPH
RHEA:16932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 benzoyl-CoA + L-ornithine <=> 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine
RHEA:25059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) + NADH + O2 => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)
REACT:R-HSA-5693551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BRCA1-A complex at multiple sites by ATM (Homo sapiens)
REACT:R-BTA-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Bos taurus)
RHEA:53749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP
REACT:R-SCE-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Saccharomyces cerevisiae)
RHEA:56394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+) => [(3R)-hydroxybutanoate](n) + H2O
REACT:R-CFA-5666088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP recruits DAIPH2-3 to endosomes (Canis familiaris)
REACT:R-RNO-5423637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR dimers reduce AFBDHO to AFBDOH (Rattus norvegicus)
RHEA:11603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CMP <=> ADP + CDP
RHEA:12536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arogenate = CO2 + H2O + L-phenylalanine
RHEA:12536	skos:altLabel	"carboxycyclohexadienyl dehydratase"
RHEA:12536	skos:prefLabel	"arogenate dehydratase"
RHEA:12536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arogenate dehydratase"
GO:0008920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide heptosyltransferase activity
GO:0008920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS heptosyltransferase activity
REACT:R-SSC-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Sus scrofa)
REACT:R-MMU-1474197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP1,3,8,13,PRSS2 (Mus musculus)
RHEA:21865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-(2-hydroxyacyl)glutathione + H2O => a 2-hydroxy carboxylate + glutathione + H(+)
RHEA:62532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigitoxin + 2 Fe(III)-[cytochrome c]
RHEA:64107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] <=> 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]
GO:0031405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoic acid binding
RHEA:16918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypyridine + H(+) + NADH + O2 => 2,3,6-trihydroxypyridine + H2O + NAD(+)
REACT:R-GGA-444393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)
RHEA:10285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine => (3R)-beta-leucine
RHEA:30657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dUDP => ATP + dUMP
REACT:R-HSA-8878679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of KLF15 (Homo sapiens)
REACT:R-SSC-9653514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17L2 deubiquitinates RCE1 (Sus scrofa)
GO:0047894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol 3-sulfotransferase activity
GO:0047894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol 3-sulphotransferase activity
GO:0047894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity
REACT:R-MMU-177933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by phosphorylated EGFR (Mus musculus)
REACT:R-SSC-997237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B proteins bind JAK2 (Sus scrofa)
REACT:R-RNO-2130640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of clathrin coated vesicle by Ii (Rattus norvegicus)
REACT:R-SSC-5649802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)
GO:0008489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
GO:0008489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity
GO:0008489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactosylceramide synthase activity
GO:0008489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LacCer synthase activity
REACT:R-MMU-163217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Mus musculus)
REACT:R-HSA-5617867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXB4 gene is transcribed (Homo sapiens)
RHEA:66841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:58801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP + H2O => 5'-pApG-3' + H(+)
RHEA:34685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+) => alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O
REACT:R-DME-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Drosophila melanogaster)
REACT:R-DME-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Drosophila melanogaster)
REACT:R-BTA-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Bos taurus)
REACT:R-BTA-399952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIMK-1 by PAK (Bos taurus)
RHEA:38973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-CoA + H2O2 => O2 + octadecanoyl-CoA
RHEA:57501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O
REACT:R-SCE-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Saccharomyces cerevisiae)
RHEA:46438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin]
EC:4.-.-.-	skos:prefLabel	"Lyases"
EC:4.-.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Lyases"
RHEA:64496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7,9,11-pentaoxododecanoyl-[ACP] = 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]
REACT:R-SSC-2046265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the keratan chain (Sus scrofa)
REACT:R-PFA-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Plasmodium falciparum)
REACT:R-HSA-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Homo sapiens)
REACT:R-MMU-2393939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)
RHEA:34354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranial + H2O + NAD(+) <=> geranate + 2 H(+) + NADH
RHEA:67178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + methanol + O13(4)-desmethyl pFDCC => H2O + primary fluorescent dioxobilin-type chlorophyll catabolite
REACT:R-SSC-8952044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Sus scrofa)
REACT:R-GGA-8855381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dephosphorylates ZAP70 (Gallus gallus)
REACT:R-SSC-5250217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP binds ARL2BP (Sus scrofa)
REACT:R-CFA-5252133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP6AP1 binds V-ATPase (Canis familiaris)
REACT:R-HSA-5687113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYC mRNA translation is negatively regulated by miR-34B and C (Homo sapiens)
REACT:R-BTA-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Bos taurus)
REACT:R-BTA-5654625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds SHC1 (Bos taurus)
REACT:R-CEL-1855206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)
RHEA:49043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-5'-demethylyatein + S-adenosyl-L-methionine <=> (-)-yatein + H(+) + S-adenosyl-L-homocysteine
RHEA:68781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate => alpha-humulene + diphosphate
REACT:R-HSA-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Homo sapiens)
REACT:R-SCE-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Saccharomyces cerevisiae)
GO:0102325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2',3-trihydroxybiphenyl monooxygenase activity
RHEA:16093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-378513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Homo sapiens)
GO:0030196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formamide dehydratase activity
GO:0030196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formamide hydro-lyase (cyanide-forming)
GO:0030196	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formamide hydro-lyase activity
GO:0030196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanide hydratase activity
REACT:R-CFA-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Canis familiaris)
REACT:R-BTA-9618021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXG1 binds FOXO:SMAD complexes (Bos taurus)
RHEA:19558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + pregna-4,9(11)-diene-3,20-dione => 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O
RHEA:68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate
RHEA:27921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + propanal <=> 2 H(+) + NADPH + propanoate
REACT:R-SSC-2046092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Sus scrofa)
RHEA:17106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-[ACP] + S-adenosyl-L-methionine => malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine
RHEA:52130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+) => a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O
RHEA:68099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA + H2O <=> a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)
RHEA:30324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0033801	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity
GO:0033801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitexin 2''-O-rhamnoside 7-O-methyltransferase activity
RHEA:29389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP + H(+) + phosphate => CTP + H2O
REACT:R-HSA-9663426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sCD163 binds MYH9 in T-cells (Homo sapiens)
RHEA:66953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)
REACT:R-BTA-8852324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds PLK1 (Bos taurus)
RHEA:16171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-glutamine + phosphate => ATP + L-glutamate + NH4(+)
RHEA:26563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O
GO:0004379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myristoylating enzymes
GO:0004379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoyltransferase activity
GO:0004379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide N-tetradecanoyltransferase activity
GO:0004379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity
GO:0004379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein N-myristoyltransferase activity
GO:0004379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide N-myristoyltransferase activity
GO:0004379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myristoyl-CoA-protein N-myristoyltransferase activity
GO:0004379	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myristoyl-coenzyme A:protein N-myristoyl transferase activity
GO:0004379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycylpeptide N-tetradecanoyltransferase activity
REACT:R-HSA-1839031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of cytosolic FGFR1 fusion proteins (Homo sapiens)
REACT:R-CEL-9653585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Farn-Me KRAS4B binds calmodulin (Caenorhabditis elegans)
REACT:R-CFA-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Canis familiaris)
REACT:R-HSA-9694261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp9 forms a homotetramer (Homo sapiens)
REACT:R-MMU-5205661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is recruited from the cytoplasm to the mitochondria (Mus musculus)
REACT:R-RNO-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Rattus norvegicus)
RHEA:14711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(5)-steroid
REACT:R-HSA-9625749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3 and SMAD3 bind TRIM63 gene promoter (Homo sapiens)
RHEA:38745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol
REACT:R-HSA-5432825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds TLR4:LY96 (Homo sapiens)
RHEA:25019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O
REACT:R-CFA-2980720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 binds NEK6/NEK7 in the cytosol (Canis familiaris)
RHEA:14403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlordecone + H(+) + NADPH => chlordecone alcohol + NADP(+)
RHEA:30484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]
RHEA:31428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (1S,5S,6R)-alpha-bergamotene + diphosphate
RHEA:12114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine => indole-3-pyruvate + S-adenosyl-L-methionine
RHEA:63232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA + H(+) + NADH = NAD(+) + octanoyl-CoA
RHEA:44526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O
REACT:R-HSA-9755368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR2:TLR1 binds SARS-CoV-2 E pentamer (Homo sapiens)
RHEA:59636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotriose + O2 = D-xylotriono-1,5-lactone + H2O2
GO:0036374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione hydrolase activity
GO:0036374	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamyltranspeptidase activity
GO:0036374	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathionase activity
RHEA:56687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine
RHEA:65747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + decyl sulfate + O2 <=> CO2 + decanal + H(+) + succinate + sulfate
GO:0099528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled neurotransmitter receptor activity
GO:0099528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled neurotransmitter receptor activity
REACT:R-BTA-9012315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Bos taurus)
RHEA:15065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-benzoylagmatine = agmatine + benzoate
RHEA:15065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acylagmatine amidase"
RHEA:15065	skos:prefLabel	"acylagmatine amidase"
REACT:R-BTA-8931981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ESR1 (Bos taurus)
REACT:R-GGA-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Gallus gallus)
REACT:R-HSA-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Homo sapiens)
REACT:R-HSA-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Homo sapiens)
RHEA:14744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylene-L-glutamine + H2O <=> 4-methylene-L-glutamate + NH4(+)
RHEA:47364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dodecanoate ester + H2O = an aliphatic alcohol + dodecanoate + H(+)
RHEA:61480	skos:prefLabel	"very-long-chain ceramide synthase"
RHEA:61480	skos:altLabel	"sphingoid base N-very-long-chain fatty acyl-CoA transferase"
RHEA:61480	skos:altLabel	"mammalian ceramide synthase 2"
RHEA:61480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"very-long-chain ceramide synthase"
RHEA:61480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + a very long-chain fatty acyl-CoA = an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)
REACT:R-CEL-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Caenorhabditis elegans)
REACT:R-CFA-201515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK recruits PI3K (Canis familiaris)
REACT:R-DRE-190245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1b binds to FGF (Danio rerio)
REACT:R-PFA-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Plasmodium falciparum)
REACT:R-CFA-389158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
RHEA:14426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
REACT:R-HSA-9638120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU4 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)
RHEA:69143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(4-aminobutyl)-3-aminopropanal <=> acrolein + putrescine
REACT:R-GGA-176318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of claspin onto DNA during replication origin firing (Gallus gallus)
RHEA:50536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E2 = H2O + prostaglandin A2
GO:0019841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinol binding
GO:0019841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin A1 alcohol binding
GO:0019841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin A1 binding
RHEA:27937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-D-aspartate <=> glycine + glyoxylate
REACT:R-XTR-2022396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-43) (Xenopus tropicalis)
GO:0042299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lupeol synthase activity
GO:0042299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidosqualene:lupeol cyclase activity
RHEA:48609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 2,3-saturated acyl-CoA => a 2,3-dehydroacyl-CoA + AH2
RHEA:48194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-BTA-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Bos taurus)
REACT:R-DME-9733973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts bind FABP6 (Drosophila melanogaster)
REACT:R-CFA-4420206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SRC-1 (Canis familiaris)
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone transacetylase activity
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H2A/H2B histone acetyltransferase activity
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H4/H2 histone acetyltransferase activity
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H4/H2A acetyltransferase activity
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H3/H4 histone acetyltransferase activity
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone acetokinase activity
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:histone acetyltransferase activity
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleosome-histone acetyltransferase activity
GO:0004402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine acetyltransferase activity
REACT:R-CFA-9735946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET small tyrosine kinase inhibitors bind MET (Canis familiaris)
RHEA:36956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA => (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:59230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-beta-D-quinovose => 6-sulfo-alpha-D-quinovose
RHEA:64082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP] => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O
REACT:R-HSA-9670101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATRX:DAXX binds to subtelomeric chromosomal regions (Homo sapiens)
REACT:R-DRE-5654163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds PLCG1 (Danio rerio)
REACT:R-HSA-9695415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosylated-ACE2 binds ACE2 inhibitors (Homo sapiens)
REACT:R-MMU-5336184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37L binds prosaposin (Mus musculus)
RHEA:13657	skos:prefLabel	"citrate-lyase deacetylase"
RHEA:13657	skos:altLabel	"citrate lyase deacetylase"
RHEA:13657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[citrate lyase ACP] + H2O = acetate + H(+) + holo-[citrate lyase ACP]
RHEA:13657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citrate-lyase deacetylase"
RHEA:13657	skos:altLabel	"[citrate-(pro-3S)-lyase] thioesterase"
RHEA:13657	skos:altLabel	"acetyl-S-(acyl-carrier protein) enzyme thioester hydrolase"
RHEA:13657	skos:altLabel	"[citrate-(pro-3S)-lyase] thiolesterase"
REACT:R-GGA-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Gallus gallus)
RHEA:52744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclobis-(1->3)-alpha-D-isomaltosyl + H2O = alpha-isomaltosyl-(1->3)-isomaltose
RHEA:43015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine <=> 2-aminobut-2-enoate + H(+) + hydrogen sulfide
RHEA:63330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 2-(9Z-octadecenoyl)-glycerol + ATP
REACT:R-GGA-2471842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XXV ectomain shedding (Gallus gallus)
RHEA:46618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-GGA-1183128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Gallus gallus)
REACT:R-RNO-190326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 (Rattus norvegicus)
RHEA:35070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine(out) <=> (S)-carnitine(in)
RHEA:61131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + quercetin + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-4546387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VDR with SUMO2 (Danio rerio)
REACT:R-SSC-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Sus scrofa)
REACT:R-SSC-5654515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds HS (Sus scrofa)
RHEA:19824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH
RHEA:27517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphinganine 1-phosphate <=> phosphate + sphinganine
GO:0017076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine nucleotide binding
REACT:R-DME-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Drosophila melanogaster)
REACT:R-HSA-201422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Homo sapiens)
REACT:R-CFA-5693148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDK phosphorylates BCKDH (Canis familiaris)
REACT:R-GGA-909720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN alpha/beta binds to IFNAR2 (Gallus gallus)
REACT:R-RNO-8983835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Rattus norvegicus)
RHEA:22746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine
RHEA:22221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate => diphosphate + ent-kaur-16-ene
RHEA:72985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(3-dimethylallyl)harmol + diphosphate => dimethylallyl diphosphate + harmol
REACT:R-CEL-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Caenorhabditis elegans)
REACT:R-RNO-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Rattus norvegicus)
REACT:R-SSC-5668520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26Sproteasome degrades K48polyUb-NIK (Sus scrofa)
REACT:R-XTR-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Xenopus tropicalis)
RHEA:23027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n) + phosphate <=> [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
RHEA:32416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-isodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH
REACT:R-RNO-9020251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Rattus norvegicus)
RHEA:60323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-XTR-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-HSA-1253282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 ubiquitination by WWP1/ITCH (Homo sapiens)
REACT:R-CEL-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Caenorhabditis elegans)
RHEA:19032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + H2O + urea-1-carboxylate <=> 2 CO2 + 2 NH4(+)
REACT:R-XTR-195378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of VEGF proteins (Xenopus tropicalis)
RHEA:60268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-BTA-9647660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds PIPs (Bos taurus)
REACT:R-SSC-6809707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTMR2 (Sus scrofa)
GO:0018744	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	limonene oxide hydrolase activity
GO:0018744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene-1,2-epoxide hydrolase activity
REACT:R-GGA-6787623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Gallus gallus)
REACT:R-MMU-9021170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen stimulates dimerization of plasma membrane estrogen receptors (Mus musculus)
REACT:R-SSC-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Sus scrofa)
RHEA:40677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobut-2-enoate + H2O => L-threonine
RHEA:66819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + tetrahydroxoborate(in) <=> 2 Na(+)(out) + tetrahydroxoborate(out)
RHEA:55526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-dopa + O2
RHEA:35076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	doxorubicin(in) + H(+)(out) => doxorubicin(out) + H(+)(in)
REACT:R-SPO-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Schizosaccharomyces pombe)
RHEA:24317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => (+)-copalyl diphosphate
REACT:R-SSC-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Sus scrofa)
REACT:R-HSA-6798347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter (Homo sapiens)
REACT:R-HSA-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)
REACT:R-RNO-399947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylation of CRMPs by Fes (Rattus norvegicus)
REACT:R-XTR-6801776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A binds bacterial phospholipids (Xenopus tropicalis)
REACT:R-DRE-8934735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 arginine-methylates RUNX1 (Danio rerio)
REACT:R-HSA-77590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CstF to the CPSF Bound Pre-mRNA (Homo sapiens)
RHEA:42725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:49555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] <=> H(+) + L-lysyl-[protein] + lactate
GO:0004169	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity
GO:0004169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein O-mannosyltransferase activity
GO:0004169	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	O-glycoside mannosyltransferase
GO:0004169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0004169	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol phosphomannose-protein mannosyltransferase activity
GO:0004169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-phosphate-mannose-protein O-mannosyltransferase activity
GO:0004169	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein O-D-mannosyltransferase activity
RHEA:45647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-hexadecanoylsphing-4-enine + phosphocholine
REACT:R-BTA-204364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO1 binds SLIT2 (Bos taurus)
RHEA:24259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + kanamycin A <=> ADP + H(+) + kanamycin 3'-phosphate
RHEA:45346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside NORint (d18:1(4E)) + H(+) + UDP => globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-SSC-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Sus scrofa)
RHEA:60696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lavandulyl diphosphate + H2O = (R)-lavandulol + diphosphate
RHEA:51990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18S-resolvin E1 => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
REACT:R-SSC-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Sus scrofa)
REACT:R-GGA-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Gallus gallus)
RHEA:15682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH
RHEA:26250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + levopimaradienol + NADPH + O2 => 2 H2O + levopimaradienal + NADP(+)
RHEA:16886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 bilirubin-glucuronoside => bilirubin IXalpha + bilirubin-bisglucuronoside
REACT:R-MMU-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Mus musculus)
REACT:R-MMU-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Mus musculus)
REACT:R-GGA-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Gallus gallus)
RHEA:71500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)
REACT:R-HSA-2730904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Homo sapiens)
RHEA:13894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate => ADP + AMP + 2 H(+)
REACT:R-GGA-432096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated integrin alphaIIb beta3 binds SHC1 (Gallus gallus)
REACT:R-DME-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Drosophila melanogaster)
GO:0015160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucan transmembrane transporter activity
RHEA:69237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate => 4-hydroxybutylnitrile + sulfate + sulfur
REACT:R-MMU-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Mus musculus)
RHEA:32857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol
RHEA:32402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R,4S)-neodihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH
RHEA:50835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate
REACT:R-SCE-434650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MATEs mediate extrusion of xenobiotics (Saccharomyces cerevisiae)
REACT:R-DRE-8985594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYO9B inactivates RHOA (Danio rerio)
RHEA:70848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-cysteine(out) + Na(+)(out) => L-arginine(out) + L-cysteine(in) + Na(+)(in)
RHEA:44708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
REACT:R-BTA-177931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Bos taurus)
REACT:R-MMU-174444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C-strand Okazaki fragments (Mus musculus)
RHEA:61395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]
RHEA:11551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)
RHEA:16931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine => 2 benzoyl-CoA + L-ornithine
RHEA:22542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-riburonosyladenine + H(+) + H2O2 => 5'-dehydroadenosine + H2O + O2
RHEA:18987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochorismate => chorismate
REACT:R-DRE-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Danio rerio)
REACT:R-HSA-9650473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 is secreted (Homo sapiens)
REACT:R-DRE-8987120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IFNLR1 (Danio rerio)
RHEA:63294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine
RHEA:34977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate(out) => (R)-pantothenate(in)
REACT:R-RNO-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Rattus norvegicus)
REACT:R-HSA-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
GO:0009883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	red/far-red light photoreceptor activity
GO:0009883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	red or far-red light photoreceptor activity
RHEA:67146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-12-hydroxyjasmonate + CO2 + succinate => 2-oxoglutarate + jasmonate + O2
RHEA:69303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> benzyl isothiocyanate + sulfate
RHEA:53196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Homo sapiens)
REACT:R-SSC-9701141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 transports Ca2+ from extracellular region to cytosol (Sus scrofa)
REACT:R-CEL-430347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MigFilin associates with Filamin and F-actin (Caenorhabditis elegans)
REACT:R-MMU-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Mus musculus)
REACT:R-GGA-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Gallus gallus)
RHEA:68335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + H2O <=> (R)-pantothenate + phosphate
RHEA:17405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine = H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine
RHEA:17405	skos:prefLabel	"N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase"
RHEA:17405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase"
RHEA:10425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-benzoylglycine => benzoate + glycine
REACT:R-BTA-6804266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TTC5 (Bos taurus)
RHEA:53563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-PFA-5690245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 binds DNAJB1 (Plasmodium falciparum)
GO:0102806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity
REACT:R-MMU-9734535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Mus musculus)
REACT:R-RNO-8862320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Rattus norvegicus)
REACT:R-RNO-193535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)
RHEA:24398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,8-trihydroxynaphthalene + H2O => scytalone
GO:0036192	skos:altLabel	"CYP71C1"
GO:0036192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyindolin-2-one monooxygenase activity
GO:0036192	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming)
GO:0036192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0036192	skos:prefLabel	"3-hydroxyindolin-2-one monooxygenase"
GO:0036192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxyindolin-2-one monooxygenase"
REACT:R-HSA-2730841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV (Homo sapiens)
REACT:R-SPO-893583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Schizosaccharomyces pombe)
RHEA:57740	skos:prefLabel	"meromycolic acid enoyl-[acyl-carrier-protein] reductase"
RHEA:57740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"meromycolic acid enoyl-[acyl-carrier-protein] reductase"
RHEA:57740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated meromycolyl-[ACP] + NAD(+) = a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH
REACT:R-RNO-9749471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)
RHEA:51041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate imine dimer => chromopyrrolate + H(+) + NH4(+)
REACT:R-DME-6799178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 1 binds HP subcomplex to form Intermediate 2 (Drosophila melanogaster)
RHEA:55404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + UTP = [phosphate](n+1) + UDP
RHEA:14409	skos:altLabel	"cysteamine oxygenase"
RHEA:14409	skos:altLabel	"persulfurase"
RHEA:14409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteamine dioxygenase"
RHEA:14409	skos:prefLabel	"cysteamine dioxygenase"
RHEA:14409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteamine + O2 = H(+) + hypotaurine
REACT:R-XTR-76397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Xenopus tropicalis)
REACT:R-DRE-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Danio rerio)
REACT:R-BTA-9009282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates RUNX2 (Bos taurus)
REACT:R-SPO-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Schizosaccharomyces pombe)
REACT:R-CEL-3214912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate MeK5-histone H3 (Caenorhabditis elegans)
REACT:R-SCE-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Saccharomyces cerevisiae)
REACT:R-DME-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Drosophila melanogaster)
REACT:R-SCE-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Saccharomyces cerevisiae)
RHEA:71981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + fusoxypene A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate
REACT:R-HSA-5483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHAT G287V doesn't palmitoylate Hh-Np (Homo sapiens)
RHEA:34823	skos:prefLabel	"curcumin synthase"
RHEA:34823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + curcumin
RHEA:34823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"curcumin synthase"
REACT:R-CFA-205328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of other tyrosine kinases with p-KIT (Canis familiaris)
REACT:R-DME-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Drosophila melanogaster)
REACT:R-BTA-6797974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRTMs bind NRXNs (Bos taurus)
RHEA:51288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
RHEA:18968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylbilane <=> H2O + uroporphyrinogen III
RHEA:11549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)
REACT:R-HSA-9674414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sorafenib-resistant PDGFR mutants don't bind sorefenib (Homo sapiens)
REACT:R-GGA-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Gallus gallus)
RHEA:38564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + H2O => 1-O-hexadecyl-sn-glycerol + acetate + H(+)
REACT:R-SSC-8857925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Sus scrofa)
RHEA:23407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
REACT:R-CFA-5649802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Canis familiaris)
REACT:R-DRE-170676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase converts ATP into cyclic AMP (Danio rerio)
RHEA:54166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine
RHEA:49684	skos:prefLabel	"resorcinol 4-hydroxylase (NADH)"
RHEA:49684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"resorcinol 4-hydroxylase (NADH)"
RHEA:49684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NAD(+)
RHEA:59773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + O2 => D-sorbopyranose + H2O2
REACT:R-SSC-5621347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)
RHEA:51911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dATP + H2O <=> dADP + H(+) + phosphate
REACT:R-RNO-1296127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of voltage gated Potassium channels (Rattus norvegicus)
RHEA:53522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol
REACT:R-HSA-5688377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective pro-SFTPC does not translocate from ER membrane to multivesicle body (Homo sapiens)
RHEA:19496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose
RHEA:40761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate
REACT:R-HSA-379996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)
RHEA:52571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone + UDP-alpha-D-glucuronate <=> epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:13011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) + L-kynurenine => H2O + N-formyl-L-kynurenine
RHEA:12802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[tau protein] => ADP + H(+) + O-phospho-L-seryl-[tau protein]
RHEA:47916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-hexanoyl-(4R)-hydroxysphinganine = ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate
REACT:R-DME-3222093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 binds TP53 and EP300 (Drosophila melanogaster)
REACT:R-XTR-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Xenopus tropicalis)
RHEA:21391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-aminohexano-6-lactam <=> L-lysine
GO:0030566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA modification guide activity
RHEA:39467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)
REACT:R-DRE-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Danio rerio)
REACT:R-DME-977071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Drosophila melanogaster)
GO:0016743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyl- or carbamoyltransferase activity
GO:0016743	skos:prefLabel	"Carboxy- and carbamoyltransferases"
GO:0016743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyl- and carbamoyltransferase activity
GO:0016743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Carboxy- and carbamoyltransferases"
REACT:R-SSC-5607756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomer autoubiquitinates (Sus scrofa)
RHEA:28868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + lactose(in) => H(+)(out) + lactose(out)
GO:0103048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA m2A37 methyltransferase activity
RHEA:60752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone = CoA + jasmolin I
RHEA:32291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoethanolamine + 3 S-adenosyl-L-methionine = 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine
GO:0018542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy DDT 1,2-dioxygenase activity
GO:0047164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biochanin A 7-O-beta-D-glucoside + malonyl-CoA = biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA
GO:0047164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAT-7
GO:0047164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity
GO:0047164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase"
GO:0047164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity
GO:0047164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavone (flavonol) 7-O-glycoside malonyltransferase activity
GO:0047164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity
GO:0047164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity
GO:0047164	skos:prefLabel	"isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase"
GO:0047164	skos:altLabel	"flavone/flavonol 7-O-beta-D-glucoside malonyltransferase"
GO:0047164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity
GO:0047164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity
REACT:R-DME-5607726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Drosophila melanogaster)
REACT:R-RNO-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Rattus norvegicus)
REACT:R-SPO-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Schizosaccharomyces pombe)
REACT:R-SSC-72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of eIF4E from the inactive eIF4E:4E-BP complex  (Sus scrofa)
REACT:R-SSC-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Sus scrofa)
REACT:R-MMU-909720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN alpha/beta binds to IFNAR2 (Mus musculus)
REACT:R-DRE-8938773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A polyubiquitinates PRKDC (Danio rerio)
REACT:R-SSC-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Sus scrofa)
REACT:R-SSC-5205681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is cleaved on healthy mitochondria (Sus scrofa)
RHEA:40678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine <=> 2-aminobut-2-enoate + H2O
REACT:R-HSA-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Homo sapiens)
RHEA:49598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acyl-D-galactosylsphing-4-enine + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose
REACT:R-BTA-1236940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exogenous soluble antigen targeted to more stable early endosome (Bos taurus)
REACT:R-MMU-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Mus musculus)
RHEA:64642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose
REACT:R-CFA-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Canis familiaris)
REACT:R-HSA-446200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLPP1 dephosphorylates DOLDP to DOLP (Homo sapiens)
REACT:R-MMU-198941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCAM1 binds Integrin alpha4beta1 (Mus musculus)
GO:0050154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	opheline kinase activity
GO:0050154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity
GO:0003691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded telomeric DNA binding
REACT:R-BTA-351849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Etk (Bos taurus)
RHEA:35939	skos:altLabel	"brevianamide F prenyltransferase"
RHEA:35939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brevianamide F + dimethylallyl diphosphate = diphosphate + tryprostatin B
RHEA:35939	skos:prefLabel	"tryprostatin B synthase"
RHEA:35939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryprostatin B synthase"
REACT:R-CEL-376851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Caenorhabditis elegans)
RHEA:12771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + AH2 => A + D-gluconate
GO:0050306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose 1F-fructosyltransferase activity
GO:0050306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:sucrose 1'-beta-D-fructosyltransferase activity
GO:0050306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose-sucrose 1-fructosyltransferase activity
GO:0050306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity
GO:0050306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SST activity
GO:0050306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:sucrose 1-fructosyltransferase activity
GO:0050306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:sucrose fructosyltransferase activity
GO:0050306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose:sucrose 1F-beta-D-fructosyltransferase activity
GO:0050306	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose 1(F)-fructosyltransferase activity
RHEA:28641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-gamma-cadinene + diphosphate => (2Z,6E)-farnesyl diphosphate
REACT:R-SCE-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Saccharomyces cerevisiae)
GO:0044024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AS1 kinase activity
GO:0044024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone kinase activity (H2A-S1 specific)
GO:0044024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-serine kinase activity (H2A-S1 specific)
GO:0044024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serine kinase activity (H2A-S1 specific)
RHEA:70405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine => (9Z)-hexadecenoyl-CoA + 3-oxosphinganine
RHEA:65468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + acetyl-CoA = CoA + propyl acetate
GO:0035598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	t6A methylthiotransferase activity
GO:0035598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 (Homo sapiens)
GO:0035598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-threonylcarbomyladenosine methylthiotransferase activity
REACT:R-CFA-5218804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38 MAPK activation by VEGFR (Canis familiaris)
REACT:R-GGA-8851954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GAB1 recruits PI3K to MET (Gallus gallus)
GO:1990930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA N1-methyladenosine dioxygenase activity
GO:1990930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA N(1)-methyladenosine dioxygenase activity
GO:1990930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA N1-methyladenosine dioxygenase activity
RHEA:46314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,22-dioxochol-4-en-24-oyl-CoA + CoA => 3-oxochol-4-en-22-oyl-CoA + acetyl-CoA
REACT:R-DRE-8933446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Danio rerio)
RHEA:46395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Caenorhabditis elegans)
REACT:R-BTA-5661116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me3K5-histone H3 (Bos taurus)
REACT:R-HSA-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Homo sapiens)
REACT:R-DRE-73635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Danio rerio)
RHEA:48660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-6784861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG binds LPL dimer (Mus musculus)
EC:2.1.1.202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"multisite-specific tRNA:(cytosine-C(5))-methyltransferase"
EC:2.1.1.202	skos:prefLabel	"multisite-specific tRNA:(cytosine-C(5))-methyltransferase"
RHEA:41076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-SSC-5693925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers L-fucose to Gal1,3GlcNAc (Sus scrofa)
RHEA:39168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CO2 + CoA
REACT:R-MMU-1604368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of bound proMMP2 (Mus musculus)
RHEA:52213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Homo sapiens)
RHEA:54077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + stellata-2,6,19-triene
REACT:R-MMU-75010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser 216 by Chk1 (Mus musculus)
REACT:R-SCE-77073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Saccharomyces cerevisiae)
REACT:R-SPO-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Schizosaccharomyces pombe)
RHEA:39502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O
RHEA:55177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + butanoyl-CoA + O2 => 2-hydroxybutanoyl-CoA + CO2 + succinate
GO:0102351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyrate transaminase (glyoxylate dependent) activity
RHEA:72458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(out) + 3 H(+)(out) <=> fumarate(in) + 3 H(+)(in)
REACT:R-SSC-5690790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H2A is dubiquitinated by the PR-DUB complex (Sus scrofa)
REACT:R-SSC-9011983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Sus scrofa)
REACT:R-CEL-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Caenorhabditis elegans)
RHEA:11514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + salicin + UDP => salicyl alcohol + UDP-alpha-D-glucose
REACT:R-SSC-1564164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type V degradation by MMP2,9,10 (Sus scrofa)
GO:0008526	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane phosphotidylinositol transfer activity
GO:0008526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Homo sapiens)
GO:0008526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol transfer activity
GO:0008526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol carrier activity
GO:0008526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Homo sapiens)
GO:0008526	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylinositol transporter activity
GO:0008526	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane phosphatidylinositol transfer activity
RHEA:49491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)
RHEA:42520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA
RHEA:42520	skos:prefLabel	"23S rRNA pseudouridine(2605) synthase"
RHEA:42520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA pseudouridine(2605) synthase"
REACT:R-DME-451757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of nephrin and KIRREL2, KIRREL3 (Drosophila melanogaster)
RHEA:47943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)) + H2O <=> ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine
REACT:R-DRE-400097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-beta:G-gamma inhibits Adenylate cyclase (Danio rerio)
RHEA:30134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoyl-[ACP] <=> H(+) + holo-[ACP] + octanoate
RHEA:67884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)
REACT:R-GGA-5218812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates PAK2 (Gallus gallus)
REACT:R-BTA-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Bos taurus)
REACT:R-BTA-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)
REACT:R-DRE-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Danio rerio)
REACT:R-CFA-2029270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLCgamma to membrane (Canis familiaris)
REACT:R-RNO-159001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)
RHEA:57018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-aminobenzoate synthetase
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminodeoxychorismate lyase"
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminodeoxychorismate lyase activity
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-amino-4-deoxychorismate pyruvate-lyase activity
GO:0008696	skos:altLabel	"ADC lyase"
GO:0008696	skos:prefLabel	"aminodeoxychorismate lyase"
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate lyase activity
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADC lyase activity
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enzyme X activity
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	para-aminobenzoic acid (PABA) synthase
GO:0008696	skos:altLabel	"enzyme X"
GO:0008696	skos:altLabel	"4-amino-4-deoxychorismate lyase"
GO:0008696	skos:altLabel	"4-amino-4-deoxychorismate pyruvate-lyase"
GO:0008696	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	para-aminobenzoic acid synthase
GO:0015489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine transmembrane transporter activity
RHEA:14274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + spermidine => 4-aminobutanal + AH2 + propane-1,3-diamine
GO:0008935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxynaphthoic acid synthetase activity
GO:0008935	skos:altLabel	"naphthoate synthase"
GO:0008935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity
GO:0008935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxynaphthoate synthase activity
GO:0008935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoyl-CoA synthase activity
GO:0008935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
GO:0008935	skos:prefLabel	"1,4-dihydroxy-2-naphthoyl-CoA synthase"
GO:0008935	skos:altLabel	"DHNA synthetase"
GO:0008935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	naphthoate synthase activity
GO:0008935	skos:altLabel	"dihydroxynaphthoic acid synthetase"
GO:0008935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHNA synthetase activity
GO:0008935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,4-dihydroxy-2-naphthoyl-CoA synthase"
GO:0008935	skos:altLabel	"o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing)"
RHEA:48303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin F2alpha 1-glyceryl ester <=> glycerol + H(+) + prostaglandin F2alpha
REACT:R-SSC-6814387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP14 cleaves filaggrin (Sus scrofa)
REACT:R-XTR-418158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Xenopus tropicalis)
RHEA:21206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol
RHEA:44592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-8848124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAT3 (Bos taurus)
RHEA:30150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + NAD(+) <=> FAD + 2 H(+) + NADH
RHEA:10719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate <=> 1D-myo-inositol 3-phosphate
RHEA:37411	skos:prefLabel	"aklaviketone reductase"
RHEA:37411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aklaviketone reductase"
RHEA:37411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklavinone + NADP(+) = aklaviketone + 2 H(+) + NADPH
RHEA:62993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetradecamide => NH4(+) + tetradecanoate
RHEA:48904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP
RHEA:10877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + H(+) => CO2 + phenol
RHEA:13243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-L-fucose 1-phosphate + H(+) => ATP + L-fucose
REACT:R-CFA-8944250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXV (Canis familiaris)
REACT:R-HSA-6803060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCD(63-110) is processed to DCD(63-109) (Homo sapiens)
REACT:R-DDI-193064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3-like proteins reducde ANDST to TEST (Dictyostelium discoideum)
REACT:R-DDI-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Dictyostelium discoideum)
RHEA:40670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate <=> 2-iminopropanoate
RHEA:23118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-CoA + AMP + diphosphate => 4-hydroxybenzoate + ATP + CoA
REACT:R-HSA-9706390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds interacting proteins at trans-Golgi network (Homo sapiens)
REACT:R-XTR-9749986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Xenopus tropicalis)
REACT:R-CFA-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Canis familiaris)
REACT:R-SCE-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Saccharomyces cerevisiae)
RHEA:28996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-threonine(in) => H(+)(in) + L-threonine(out)
REACT:R-CFA-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Canis familiaris)
RHEA:27355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + rebeccamycin + S-adenosyl-L-homocysteine => 4'-demethylrebeccamycin + S-adenosyl-L-methionine
REACT:R-GGA-1454791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP7, MMP9 bind CD44 (Gallus gallus)
RHEA:41783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide
REACT:R-DME-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Drosophila melanogaster)
RHEA:56997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-apiose => apulose
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AP3A hydrolase activity
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AP3Aase activity
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5,5-P1,P3-triphosphatase activity
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(5'-adenosyl)-triphosphatase activity
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dinucleosidetriphosphatase activity
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AP(3)Aase activity
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AP(3)A hydrolase activity
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity
GO:0047710	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity
RHEA:23978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate => a 3'-end 3'-phospho-ribonucleotide-RNA + ATP
REACT:R-MMU-177922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR dimerization (Mus musculus)
RHEA:70999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0036370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanyl carrier activity
GO:0036370	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alanyl carrier protein
REACT:R-HSA-9013978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex  (Homo sapiens)
RHEA:13986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-homoserine => ADP + H(+) + O-phospho-L-homoserine
RHEA:55986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-prunasin + H(+) + UDP => (R)-mandelonitrile + UDP-alpha-D-glucose
REACT:R-CFA-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Canis familiaris)
RHEA:44022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + octadecanoate => H2O + NAD(+) + octadecanal
RHEA:69138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 + 2 NH4(+) + spermine dialdehyde => 2 H2O + 2 O2 + spermine
REACT:R-MMU-186800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)
REACT:R-RNO-174444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C-strand Okazaki fragments (Rattus norvegicus)
GO:0004435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PI-PLC activity
GO:0004435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol phospholipase C activity
GO:0004435	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	triphosphoinositide phosphodiesterase activity
GO:0004435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
GO:0004435	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	monophosphatidylinositol phosphodiesterase activity
GO:0004435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
GO:0004435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylinositol-4,5-bisphosphate hydrolysis
GO:0004435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoinositide phospholipase C activity
GO:0004435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoinositidase C activity
GO:0004435	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
REACT:R-SSC-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Sus scrofa)
REACT:R-DDI-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Dictyostelium discoideum)
GO:0030769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrocin O-methyltransferase activity
GO:0030769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity
GO:0030769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	macrocin methyltransferase activity
GO:0030769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine-macrocin O-methyltransferase activity
RHEA:60506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol
RHEA:32512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)
RHEA:15826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AZD1979 + H2O => AZD1979 oxetane hydrolysis product + H(+)
RHEA:44778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-6 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-6 + S-adenosyl-L-methionine
REACT:R-RNO-8941895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CDK4/6:CCND complexes (Rattus norvegicus)
GO:0008870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity
GO:0008870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactoside acetyltransferase activity
GO:0008870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactoside O-acetyltransferase activity
GO:0008870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiogalactoside transacetylase activity
GO:0008870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiogalactoside acetyltransferase activity
RHEA:57143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
RHEA:63302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine
REACT:R-SCE-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)
RHEA:49838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5E)-tetradecenoyl-(R)-carnitine + CoA => (5E)-tetradecenoyl-CoA + (R)-carnitine
RHEA:61698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + glycyl-[peptidyl-carrier protein] => ATP + glycine + holo-[peptidyl-carrier protein]
GO:0102995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angelicin synthase activity
RHEA:23420	skos:prefLabel	"trehalose-phosphatase"
RHEA:23420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate
RHEA:23420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trehalose-phosphatase"
RHEA:23420	skos:altLabel	"trehalose 6-phosphate phosphatase"
REACT:R-CEL-2089971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of collagens (Caenorhabditis elegans)
REACT:R-RNO-5671702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP1G2 binds HGS and CHMP2A (Rattus norvegicus)
REACT:R-HSA-5610742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI1 (Homo sapiens)
REACT:R-HSA-9680242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of KIT extracellular domain mutants (Homo sapiens)
REACT:R-GGA-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Gallus gallus)
REACT:R-HSA-191983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)
REACT:R-SSC-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Sus scrofa)
RHEA:35098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline <=> acetaldehyde + trimethylamine
RHEA:19072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-S-lactoylglutathione <=> glutathione + methylglyoxal
RHEA:70509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl phosphate + H(+) + phosphate => dimethylallyl diphosphate + H2O
REACT:R-CEL-8849085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RHOA:GTP (Caenorhabditis elegans)
REACT:R-HSA-8938338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)
RHEA:10954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyltartronate + CoA => (E)-sinapoyl-CoA + hydroxymalonate
REACT:R-CFA-202110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1 complex binds to CaM (Canis familiaris)
RHEA:38320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + H2O => (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate
REACT:R-XTR-209903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline is converted to adrenaline (Xenopus tropicalis)
REACT:R-SSC-110232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by MBD4 glycosylase (Sus scrofa)
REACT:R-RNO-5692768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates KALRN (Rattus norvegicus)
GO:0047868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylmaleate hydratase activity
GO:0047868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R,3S)-2,3-dimethylmalate hydro-lyase activity
GO:0047868	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)
REACT:R-GGA-2465919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM to 11cROL forming 11cRPALM (Gallus gallus)
RHEA:45829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH
REACT:R-MMU-351913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of TJP1 (Mus musculus)
REACT:R-CEL-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
REACT:R-HSA-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Homo sapiens)
REACT:R-HSA-1564184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IX degradation by MMP3,13 (Homo sapiens)
REACT:R-BTA-202726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F11R dimerises (Bos taurus)
GO:0047981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine N-acetyltransferase activity
GO:0047981	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine acetyltransferase activity
GO:0047981	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:L-histidine N-acetyltransferase activity
GO:0047981	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylhistidine synthetase activity
RHEA:14449	skos:prefLabel	"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)"
RHEA:14449	skos:altLabel	"plant-type divinyl chlorophyllide a 8-vinyl-reductase"
RHEA:14449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + H(+) + NADPH
RHEA:14449	skos:altLabel	"[4-vinyl]chlorophyllide a reductase"
RHEA:14449	skos:altLabel	"4VCR"
RHEA:14449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + NADP(+) = 3,8-divinyl chlorophyllide a + H(+) + NADPH
RHEA:14449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)"
RHEA:14449	skos:altLabel	"divinyl chlorophyllide a 8-vinyl-reductase"
REACT:R-XTR-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Xenopus tropicalis)
REACT:R-RNO-433099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS2 co-transports sulphate and two sodium ions (Rattus norvegicus)
RHEA:64968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUTP + H2O = dUDP + H(+) + phosphate
REACT:R-HSA-8876993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBLL1 binds SRC-phosphorylated CDH1 complex (Homo sapiens)
RHEA:72815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)
RHEA:29935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytosine(in) + H(+)(in) = cytosine(out) + H(+)(out)
RHEA:10072	skos:prefLabel	"dimethylglycine N-methyltransferase"
RHEA:10072	skos:altLabel	"DMT"
RHEA:10072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylglycine N-methyltransferase"
RHEA:10072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylglycine + S-adenosyl-L-methionine = glycine betaine + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-141046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)
REACT:R-SSC-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Sus scrofa)
REACT:R-MMU-6783955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)
RHEA:66236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IC-asc-C9-CoA + O2 = H2O2 + IC-asc-DeltaC9-CoA
REACT:R-MMU-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Mus musculus)
RHEA:58587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroprecondylocarpine acetate <=> (-)-tabersonine + acetate + H(+)
RHEA:60003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylphosphonate + O2 <=> formate + 2 H(+) + phosphate
REACT:R-HSA-5662669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopaquinone transforms to Leucodopachrome (Cyclodopa) (Homo sapiens)
REACT:R-CEL-1605632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Both hexosaminidase A and B can cleave GalNAc from globoside (Caenorhabditis elegans)
REACT:R-CEL-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Caenorhabditis elegans)
REACT:R-BTA-2731078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 2, (4) bind TGFB1 (Bos taurus)
GO:0033994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronan lyase activity
GO:0033994	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1,4)-beta-D-glucuronan lyase activity
REACT:R-BTA-9706319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA (Bos taurus)
RHEA:56619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene <=> 1,2,4-trichlorobenzene + chloride + H(+)
REACT:R-XTR-5662662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosinase oxidises tyrosine to dopaquinone (Xenopus tropicalis)
RHEA:47675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
REACT:R-CEL-9610152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Caenorhabditis elegans)
REACT:R-DRE-351876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of occludin (Danio rerio)
REACT:R-DRE-2161779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LXA4 is oxidised to 15k-LXA4 by HPGD (Danio rerio)
RHEA:33903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pseudooxynicotine = 4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine
RHEA:33903	skos:prefLabel	"pseudooxynicotine oxidase"
RHEA:33903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudooxynicotine oxidase"
REACT:R-HSA-9681294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6R binds IL6R inhibitors (Homo sapiens)
RHEA:10344	skos:prefLabel	"plasmalogen synthase"
RHEA:10344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plasmalogen synthase"
RHEA:10344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
REACT:R-XTR-212706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipase C-gamma1 binds to the activated EGF receptor (Xenopus tropicalis)
RHEA:65079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:64093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)
GO:0031766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 3 galanin receptor binding
GO:0031766	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 3 galanin receptor ligand
RHEA:61795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tryptophan <=> diphosphate + L-tryptophyl-5'-AMP
REACT:R-HSA-912363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDM9 binds recombination hotspot motifs in DNA (Homo sapiens)
GO:0102523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloroacrylate reductase activity
GO:0102523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-chloropropanoate + NADP(+) = 2-chloroacrylate + H(+) + NADPH
GO:0102523	skos:prefLabel	"2-haloacrylate reductase"
GO:0102523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-haloacrylate reductase"
RHEA:11355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP <=> acetyl phosphate + ADP
RHEA:37724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:30524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-glutamate + oxidized coenzyme F420-1 => GDP + H(+) + oxidized coenzyme F420-2 + phosphate
RHEA:57453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine
RHEA:16645	skos:prefLabel	"palmitoyl-CoA hydrolase"
RHEA:16645	skos:altLabel	"long-chain fatty-acyl-CoA hydrolase"
RHEA:16645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"palmitoyl-CoA hydrolase"
RHEA:16645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate
RHEA:60623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hexanoyl-sphing-4-enine-1-phosphocholine <=> choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate
REACT:R-HSA-450434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Homo sapiens)
RHEA:44484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-8855237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Homo sapiens)
RHEA:58028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH = a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)
RHEA:58028	skos:prefLabel	"mycoketide-CoA synthase"
RHEA:58028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycoketide-CoA synthase"
RHEA:29619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltotetraose + beta-maltose = alpha-maltopentaose + beta-D-glucose
GO:0016922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear hormone receptor binding
GO:0016922	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid hormone receptor binding
GO:0016922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear receptor binding
GO:0016922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligand-dependent nuclear receptor binding
GO:0016922	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ligand-dependent nuclear receptor interactor activity
RHEA:40912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-CEL-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Caenorhabditis elegans)
RHEA:39449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH
REACT:R-BTA-8944262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type X (Bos taurus)
REACT:R-MMU-420123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like receptor 2 binds GLP2 (Mus musculus)
RHEA:71823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in)
REACT:R-SSC-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Sus scrofa)
REACT:R-SSC-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Sus scrofa)
REACT:R-HSA-8863895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKB phosphorylates SNAP23 (Homo sapiens)
RHEA:27386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + maleamate => maleate + NH4(+)
REACT:R-CEL-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Caenorhabditis elegans)
REACT:R-SSC-9624800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LBR (Sus scrofa)
REACT:R-SSC-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Sus scrofa)
RHEA:51218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one
RHEA:43348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-octadecenoate)(out)
RHEA:39451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA = (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O
RHEA:58693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV => FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal
REACT:R-SSC-3791149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Sus scrofa)
GO:0102461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity
RHEA:19836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)
REACT:R-CFA-419334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melatonin receptors can bind melatonin (Canis familiaris)
REACT:R-GGA-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Gallus gallus)
RHEA:44249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-DRE-8866304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-VLDL binds lipids to form VLDL (Danio rerio)
REACT:R-RNO-202710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MERTK receptor binds ligands (Gas6 or Protein S) (Rattus norvegicus)
RHEA:62465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-HSA-1839080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated cytosolic FGFR1 fusions bind PIK3CA (Homo sapiens)
RHEA:12349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-muconolactone => (4,5-dihydro-5-oxofuran-2-yl)-acetate
RHEA:51062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + androsta-1,4-diene-3,17-dione => 5alpha-androst-1-ene-3,17-dione + A
REACT:R-HSA-8853920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX binds the CDKN2A gene (Homo sapiens)
REACT:R-HSA-9615626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP22 gene expression (Homo sapiens)
REACT:R-CEL-8864595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2B homodimer binds YEATS4 (Caenorhabditis elegans)
RHEA:32625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => L-threo-tetrahydrobiopterin + 2 NADP(+)
RHEA:65716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a primary linear alkyl sulfate ester + O2 = an aldehyde + CO2 + H(+) + succinate + sulfate
RHEA:65521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]
RHEA:57199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] <=> glycolate + H(+) + L-cysteinyl-[protein]
REACT:R-CFA-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Canis familiaris)
RHEA:34097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + spermidine => carboxyspermidine + H(+)
REACT:R-MMU-6806674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Mus musculus)
REACT:R-DRE-9755035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from cytosol to extracellular region (Danio rerio)
REACT:R-HSA-9023619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Homo sapiens)
RHEA:36325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecen-1-ol + CoA + 2 NADP(+) => (9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH
REACT:R-DRE-9692809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the ER membrane (Danio rerio)
REACT:R-RNO-8932275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Rattus norvegicus)
RHEA:72293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dimethylsuccinate(in) + 3 Na(+)(in) => 2,3-dimethylsuccinate(out) + 3 Na(+)(out)
GO:0051996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene synthase activity
GO:0051996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	squalene synthetase activity
REACT:R-SSC-446391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the PINCH-ILK-parvin complex (Sus scrofa)
REACT:R-SSC-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Sus scrofa)
REACT:R-GGA-2161500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir [extracellular] => abacavir [cytosol] (Gallus gallus)
REACT:R-DRE-389788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAKs by RAC1 and CDC42 (Danio rerio)
REACT:R-SSC-389348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by pVav1 (Sus scrofa)
REACT:R-DRE-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Danio rerio)
REACT:R-DRE-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Danio rerio)
REACT:R-SSC-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Sus scrofa)
GO:0047208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	o-dihydroxycoumarin 7-O-glucosyltransferase activity
GO:0047208	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity
GO:0047208	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity
GO:0047208	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity
GO:0047208	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity
REACT:R-MMU-390674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB1 bind ADR,NAd (Mus musculus)
RHEA:16453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O = 2-formylbenzoate + pyruvate
RHEA:16453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase"
RHEA:16453	skos:altLabel	"2'-carboxybenzalpyruvate aldolase"
RHEA:16453	skos:altLabel	"(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase"
RHEA:16453	skos:prefLabel	"4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase"
RHEA:16453	skos:altLabel	"(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase"
REACT:R-MMU-191784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNA Cap hypermethylation (Mus musculus)
REACT:R-RNO-210426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamate synaptic vesicle docking and priming (Rattus norvegicus)
REACT:R-SSC-2534388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progesterone Activation Of CatSper (Sus scrofa)
GO:0015668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type III site-specific deoxyribonuclease activity
GO:0015668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type III restriction enzyme activity
RHEA:42262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxononanoyl-[ACP] + CO2 + CoA => H(+) + heptanoyl-CoA + malonyl-[ACP]
REACT:R-DME-2065539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2:Importin beta-1 dissociates (Drosophila melanogaster)
REACT:R-HSA-190698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of connexins to the ER-Golgi intermediate compartment (Homo sapiens)
REACT:R-DRE-5668534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Danio rerio)
RHEA:70544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-SSC-205321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of KIT and sSCF (Sus scrofa)
GO:0018481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxymuconic-semialdehyde dehydrogenase activity
GO:0018481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity
REACT:R-SCE-8851494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase7 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)
RHEA:26380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP <=> cyclic pyranopterin phosphate + diphosphate
REACT:R-HSA-159868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor VII to factor VII (Homo sapiens)
RHEA:59424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+)
RHEA:13408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + agmatine <=> CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide
REACT:R-CEL-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Caenorhabditis elegans)
RHEA:59094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n+1) + D-fructose => [(1->3)-alpha-D-glucosyl](n) + sucrose
REACT:R-SSC-9710354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds cardiolipin (Sus scrofa)
RHEA:60861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-8851804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET recruits GRB2-1:SOS1 (Canis familiaris)
RHEA:57017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)
GO:0062060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NuA4 histone acetyltransferase complex binding
REACT:R-GGA-2530591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREG (CR1L) causes dissociation of C3 convertases (Gallus gallus)
RHEA:71092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) => dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)
REACT:R-DRE-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Danio rerio)
REACT:R-DME-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Drosophila melanogaster)
RHEA:42723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2552) in 23S rRNA <=> 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:21966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + choline + H(+) => an acylcholine + H2O
REACT:R-XTR-373074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR9  binds CCL25 ligand (Xenopus tropicalis)
RHEA:69981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Homo sapiens)
RHEA:13466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-diaminopropanoate + oxalyl-CoA => CoA + N(3)-oxalyl-L-2,3-diaminopropanoate
REACT:R-HSA-2464803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH8 reduces atRAL to atROL (Homo sapiens)
REACT:R-DDI-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)
RHEA:45006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-2,6-dimethylheptanoyl-(R)-carnitine => (R)-carnitine + 2,6-dimethylheptanoyl-CoA
RHEA:37545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-5-chloromuconate 6-semialdehyde => 2-amino-5-chlorophenol + O2
RHEA:25988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
EC:3.4.22.60	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-7"
EC:3.4.22.60	skos:altLabel	"Mch3"
EC:3.4.22.60	skos:altLabel	"CMH-1"
EC:3.4.22.60	skos:altLabel	"ICE-LAP3"
EC:3.4.22.60	skos:altLabel	"CASP-7"
EC:3.4.22.60	skos:altLabel	"ICE-like apoptotic protease 3"
EC:3.4.22.60	skos:altLabel	"apoptotic protease Mch-3"
EC:3.4.22.60	skos:prefLabel	"caspase-7"
GO:0022821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	solute:potassium antiporter activity
GO:0022821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium ion antiporter activity
RHEA:44219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoate + ATP + CoA <=> 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate
RHEA:42890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3,5-bisphosphomevalonate + ADP + H(+) => (R)-3-phosphomevalonate + ATP
REACT:R-RNO-5604929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C binds Protein S (Rattus norvegicus)
REACT:R-BTA-2395849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
REACT:R-MMU-2022141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolysyl oxidase activation (Mus musculus)
RHEA:61055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0052672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:geranylgeraniol kinase activity
GO:0052672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:geranylgeraniol phosphotransferase activity
REACT:R-RNO-2130378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC II:Ii complex to plasma membrane (Rattus norvegicus)
REACT:R-BTA-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Bos taurus)
REACT:R-RNO-6810376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2 binds PI5P (Rattus norvegicus)
REACT:R-DDI-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Dictyostelium discoideum)
REACT:R-XTR-5689544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds INO80 complex (Xenopus tropicalis)
RHEA:14918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-9036987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Bos taurus)
RHEA:45996	skos:prefLabel	"D-amino acid dehydrogenase (quinone)"
RHEA:45996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-amino acid dehydrogenase (quinone)"
RHEA:45996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + a quinone + H2O = a 2-oxocarboxylate + a quinol + NH4(+)
RHEA:45996	skos:altLabel	"DadA"
RHEA:69994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + NADP(+) <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH
RHEA:14390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-SCE-9612509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates SRF (Saccharomyces cerevisiae)
REACT:R-XTR-6788855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3KRP phosphorylates PsiAm, RibAm (Xenopus tropicalis)
GO:0120016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid transfer activity
GO:0120016	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane sphingolipid transfer activity
GO:0120016	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sphingolipid carrier activity
REACT:R-CEL-5218916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPK2/3 phosphorylates HSP27 (Caenorhabditis elegans)
REACT:R-SSC-74716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin binds the insulin receptor (Sus scrofa)
REACT:R-HSA-174224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Cdc20 from APC/C complex (Homo sapiens)
RHEA:34492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N,N'-diacetylbacillosamine => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP
REACT:R-RNO-159757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)
RHEA:67762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-RNO-210974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS-1 to Tie2 bound  Grb2 (Rattus norvegicus)
RHEA:55972	skos:prefLabel	"ethanol O-acetyltransferase"
RHEA:55972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethanol O-acetyltransferase"
RHEA:55972	skos:altLabel	"ethanol acetyltransferase"
RHEA:55972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ethanol = CoA + ethyl acetate
GO:0018755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity
REACT:R-DRE-416530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1:FFAR1 ligands activates Gq (Danio rerio)
RHEA:50126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1
REACT:R-RNO-453104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
RHEA:72436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-AMP + CoA => (E)-caffeoyl-CoA + AMP + H(+)
REACT:R-MMU-6786070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Mus musculus)
REACT:R-CEL-70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine => urocanate + NH4+ (Caenorhabditis elegans)
REACT:R-MMU-5218806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN autophosphorylates (Mus musculus)
REACT:R-RNO-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Rattus norvegicus)
REACT:R-GGA-2559639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV sulfilimine cross-linking by peroxidasin (Gallus gallus)
RHEA:55366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-nonaprenyl diphosphate + 6 diphosphate => (2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
REACT:R-BTA-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Bos taurus)
RHEA:41997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP
RHEA:67859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] <=> 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)
RHEA:54016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
RHEA:18370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H2O2
RHEA:69509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamino-1,5-lactone => H(+) + N-acetyl-D-glucosaminate
REACT:R-RNO-8950537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Rattus norvegicus)
RHEA:32248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH
RHEA:50205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate
GO:0097077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	copper ion sensor activity
RHEA:68783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> alpha-humulene + diphosphate
RHEA:44863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 4,8-dimethylnonanoyl-CoA <=> CoA + O-4,8-dimethylnonanoyl-(R)-carnitine
REACT:R-HSA-2029445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An unknown GEF exchanges GTP for GDP on CDC42:GDP (Homo sapiens)
RHEA:15598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a Fe(III)-siderophore(out) + ATP + H2O => a Fe(III)-siderophore(in) + ADP + H(+) + phosphate
RHEA:70827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-lysine(out) = L-arginine(out) + L-lysine(in)
REACT:R-DDI-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Dictyostelium discoideum)
REACT:R-GGA-204798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and p85 of PI3K (Gallus gallus)
RHEA:71297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in) => chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out)
REACT:R-HSA-171087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR [endosome membrane] => LDLR [plasma membrane] (Homo sapiens)
REACT:R-MMU-5666088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP recruits DAIPH2-3 to endosomes (Mus musculus)
REACT:R-BTA-427656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Bos taurus)
RHEA:34304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine => L-pipecolate + NH4(+)
RHEA:43793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(645) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine
REACT:R-CFA-5229273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCN2:2,5DHBA binds Fe3+ (Canis familiaris)
REACT:R-BTA-750988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (z) reassociates with G beta:gamma (Bos taurus)
REACT:R-BTA-176585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Bos taurus)
RHEA:16354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + taurine => L-glutamate + sulfoacetaldehyde
RHEA:21503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose <=> H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose
REACT:R-HSA-4570553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO2,3 (Homo sapiens)
REACT:R-GGA-74711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRS (Gallus gallus)
REACT:R-XTR-350318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at TNLD (429) (Xenopus tropicalis)
RHEA:42993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (R)-nephthenol + diphosphate
REACT:R-CFA-8944233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIX (Canis familiaris)
RHEA:67159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-DME-72231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Cleavage and Polyadenylation Complex (Drosophila melanogaster)
RHEA:54089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + H(+) + NADH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)
RHEA:27294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:27294	skos:altLabel	"coenzyme F420-dependent glucose-6-phosphate dehydrogenase"
RHEA:27294	skos:prefLabel	"glucose-6-phosphate dehydrogenase (coenzyme-F420)"
RHEA:27294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose-6-phosphate dehydrogenase (coenzyme-F420)"
RHEA:27294	skos:altLabel	"F420-dependent glucose-6-phosphate dehydrogenase"
REACT:R-HSA-433099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS2 co-transports sulphate and two sodium ions (Homo sapiens)
RHEA:49052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperlicin C + H(+) + NADH + O2 = asperlicin E + H2O + NAD(+)
RHEA:18531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanal + H(+) + NADH => 3-methylbutanol + NAD(+)
RHEA:33586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate <=> 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
REACT:R-BTA-453200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Bos taurus)
REACT:R-RNO-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Rattus norvegicus)
REACT:R-DRE-909552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 at Ser727 (Danio rerio)
REACT:R-BTA-8875523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS3 (Bos taurus)
RHEA:24776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pheophorbide a = C-13(2)-carboxypyropheophorbide a + methanol
GO:0050352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethylamine N-oxide aldolase activity
GO:0050352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethylamine N-oxide demethylase activity
GO:0050352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine-oxide aldolase activity
GO:0050352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethylamine-N-oxide formaldehyde-lyase activity
GO:0050352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)
GO:0050352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethylamine N-oxide formaldehyde-lyase activity
REACT:R-DRE-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Danio rerio)
RHEA:59112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine = ADP + H(+) + O-phospho-L-serine
RHEA:59112	skos:prefLabel	"L-serine kinase (ATP)"
RHEA:59112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-serine kinase (ATP)"
REACT:R-DME-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Drosophila melanogaster)
RHEA:12717	skos:altLabel	"1D-myo-inositol-tetrakisphosphate 5-kinase"
RHEA:12717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
RHEA:12717	skos:prefLabel	"inositol-tetrakisphosphate 5-kinase"
RHEA:12717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-tetrakisphosphate 5-kinase"
GO:0051380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	noradrenaline binding
GO:0051380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norepinephrine binding
REACT:R-SSC-389158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
RHEA:65723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + butyl sulfate + O2 <=> butanal + CO2 + H(+) + succinate + sulfate
REACT:R-DRE-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Danio rerio)
REACT:R-MMU-6811508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2-bound EP300 acetylates TP53 (Mus musculus)
RHEA:13381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetate CoA-transferase"
RHEA:13381	skos:prefLabel	"acetate CoA-transferase"
RHEA:13381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + an acyl-CoA = a carboxylate + acetyl-CoA
REACT:R-CFA-1475028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Canis familiaris)
REACT:R-SSC-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Sus scrofa)
REACT:R-HSA-5635853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-dependent expression of GLI1 gene (Homo sapiens)
REACT:R-BTA-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Bos taurus)
REACT:R-SSC-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)
REACT:R-GGA-5218811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO binds CRK (Gallus gallus)
REACT:R-HSA-167217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-Shc dissociates from the TrkA receptor (Homo sapiens)
RHEA:58573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-15alpha-stemmadenine + O2 => H2O2 + precondylocarpine acetate
RHEA:61725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-glucoside + NAD(+) => a 3-dehydro-D-glucoside + H(+) + NADH
REACT:R-DME-2730892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)
REACT:R-DME-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Drosophila melanogaster)
RHEA:13492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-canadine + H(+) + 2 O2 <=> berberine + 2 H2O2
GO:0008430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenium binding
RHEA:34676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + N,N-diacetyllegionaminate => CMP-N,N-diacetyllegionaminate + diphosphate
REACT:R-MMU-176609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + PAPS => cholesterol sulfate + PAP (Mus musculus)
RHEA:49568	skos:prefLabel	"isoprene-epoxide--glutathione S-transferase"
RHEA:49568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoprene-epoxide--glutathione S-transferase"
RHEA:49568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione
REACT:R-RNO-6785181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMF1,2 bind LIPC dimer (Rattus norvegicus)
RHEA:51365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine => CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine
REACT:R-SSC-9647631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds PIPs (Sus scrofa)
RHEA:63917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-fluorouridine + ATP => 5-fluorouridine 5'-phosphate + ADP + H(+)
RHEA:62555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosylceramide + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP
RHEA:15604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA + (R)-3-phenyllactate <=> (E)-cinnamate + (R)-3-phenyllactoyl-CoA
RHEA:72466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]
REACT:R-XTR-2065550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds Importin beta-1 (Xenopus tropicalis)
REACT:R-SSC-8983298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Sus scrofa)
RHEA:66415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)
REACT:R-RNO-5693574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Rattus norvegicus)
REACT:R-CEL-3928595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ARP2/3 and G-actin (Caenorhabditis elegans)
REACT:R-RNO-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Rattus norvegicus)
RHEA:40031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate + H2O = diphosphate + ent-manool
REACT:R-XTR-6785213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer binds heparin (Xenopus tropicalis)
REACT:R-MMU-8944230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Mus musculus)
RHEA:42763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H2O + NAD(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADH
RHEA:65569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine
REACT:R-HSA-5693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYM reduces P2C to PPCA (Homo sapiens)
REACT:R-RNO-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Rattus norvegicus)
REACT:R-CEL-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Caenorhabditis elegans)
RHEA:12926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + L-lysyl-[protein] => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]
RHEA:72083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-beta-D-ribose 1'',2''-cyclic phosphate + H2O = ADP-beta-D-ribose 1''-phosphate + H(+)
RHEA:57106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2) => [(1->4)-alpha-D-galacturonosyl](n)
REACT:R-BTA-9759154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM21 ubiquitinates SQSTM1 (Bos taurus)
RHEA:36014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:35400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine => beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)
REACT:R-SSC-9733545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids bind ALB (Sus scrofa)
RHEA:42816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
RHEA:64937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGTP + H2O => dGDP + H(+) + phosphate
REACT:R-XTR-5218822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK binds BCAR1 and or PXN (Xenopus tropicalis)
EC:2.3.1.282	skos:prefLabel	"phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase"
EC:2.3.1.282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase"
REACT:R-DME-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Drosophila melanogaster)
REACT:R-SSC-1358797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated RNF41 binds P-USP8 (Sus scrofa)
REACT:R-MMU-8878056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1:CBFB binds EP300 (Mus musculus)
REACT:R-CEL-8964329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Caenorhabditis elegans)
GO:0033739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-cyano-7-deazaguanine reductase activity
GO:0033739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	queuine:NADP+ oxidoreductase activity
GO:0033739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	preQ0 oxidoreductase activity
GO:0033739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	QueF
GO:0033739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	queuine synthase activity
GO:0033739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	preQ0 reductase activity
GO:0033739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	YkvM
GO:0033739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity
GO:0033739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	preQ1 synthase activity
REACT:R-HSA-548890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of the third glucose by glucosidase II and release from the chaperone (Homo sapiens)
REACT:R-HSA-9652816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs (Homo sapiens)
REACT:R-DRE-443978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR11 binds CCL19, CCL21 & CCL25 (Danio rerio)
REACT:R-BTA-9012268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)
REACT:R-DRE-6788912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)
REACT:R-XTR-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Xenopus tropicalis)
RHEA:34036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + paromamine => 6'-oxoparomamine + H2O2
RHEA:32545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-cineole + diphosphate => (2E)-geranyl diphosphate + H2O
REACT:R-CEL-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Caenorhabditis elegans)
REACT:R-SSC-9759172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Sus scrofa)
REACT:R-XTR-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Xenopus tropicalis)
GO:1990272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anti-Mullerian hormone receptor activity
RHEA:33705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine => (4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA
RHEA:11909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nonane-4,6-dione => butanoate + H(+) + pentan-2-one
REACT:R-XTR-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Xenopus tropicalis)
REACT:R-MMU-203712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS associates with Caveolin-1 (Mus musculus)
RHEA:26035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:33580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
REACT:R-HSA-9694580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp8 binds MAP1LC3B (Homo sapiens)
REACT:R-CEL-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Caenorhabditis elegans)
REACT:R-SPO-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)
REACT:R-HSA-180573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated CD4 (Homo sapiens)
REACT:R-GGA-6804942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 homodimers auto-ubiquitinate (Gallus gallus)
REACT:R-CFA-381612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1 (Canis familiaris)
GO:0034940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity
REACT:R-CEL-170978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-FRS2:CRKL binds C3G (Caenorhabditis elegans)
REACT:R-MMU-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Mus musculus)
RHEA:54662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic aldehyde + hydrogen cyanide => an aromatic (S)-hydroxynitrile
REACT:R-GGA-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Gallus gallus)
REACT:R-SSC-1604350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14:TIMP2 binds proMMP2 (Sus scrofa)
RHEA:40668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate => 2-iminopropanoate
REACT:R-RNO-9020262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Rattus norvegicus)
REACT:R-CFA-3928646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHAs bind EFNAs (Canis familiaris)
RHEA:62037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)
REACT:R-HSA-4085033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Homo sapiens)
REACT:R-RNO-444661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR2 binds HCAR2 ligands (Rattus norvegicus)
REACT:R-HSA-419351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF receptor binds platelet activating factor (Homo sapiens)
RHEA:36270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + theobromine
REACT:R-HSA-1839098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 mutants and fusions phosphorylate PLCG1 (Homo sapiens)
RHEA:61487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:54915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + NADP(+) <=> 11-cis-retinal + H(+) + NADPH
REACT:R-HSA-4396347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 Coactivator Complex binds HES1 promoter (Homo sapiens)
RHEA:27925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate
RHEA:28021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enterobactin + 3 H2O <=> 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine
RHEA:49982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine => H2O + hexanoyl-CoA
RHEA:27738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine
REACT:R-BTA-1676174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Bos taurus)
RHEA:46754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Gallus gallus)
RHEA:65846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(in) + phosphate(out) => ADP(out) + phosphate(in)
RHEA:45153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-oxopropanoyl-CoA + methanethiol
REACT:R-MMU-71010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUT isomerises L-MM-CoA to SUCC-CoA (Mus musculus)
RHEA:66752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O = (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate
RHEA:53375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(17) in tRNA + NAD(+) <=> H(+) + NADH + uridine(17) in tRNA
REACT:R-MMU-5678261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Mus musculus)
REACT:R-RNO-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Rattus norvegicus)
REACT:R-SSC-2028555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Sus scrofa)
RHEA:17026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + xylitol => H(+) + L-xylulose + NADPH
RHEA:18418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM3 (d18:1(4E)) + H(+)
RHEA:54080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine
RHEA:34303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine = L-pipecolate + NH4(+)
RHEA:34303	skos:prefLabel	"L-lysine cyclodeaminase"
RHEA:34303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-lysine cyclodeaminase"
REACT:R-DDI-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Dictyostelium discoideum)
RHEA:67547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine
REACT:R-BTA-2509827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses ITP to IMP (Bos taurus)
REACT:R-HSA-9007631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds RBBP4 gene promoter (Homo sapiens)
REACT:R-CEL-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Caenorhabditis elegans)
RHEA:18883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate => ATP + histamine + L-glutamate
REACT:R-CFA-193816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Canis familiaris)
REACT:R-BTA-8956103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Bos taurus)
GO:0030973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MoO4 ion binding
GO:0030973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdate ion binding
RHEA:62682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + norrubrofusarin => naphtopyrone YWA1
GO:0047234	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	raffinose (raffinose donor) galactosyltransferase activity
GO:0047234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raffinose-raffinose a-galactosyltransferase activity
GO:0047234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raffinose-raffinose alpha-galactotransferase activity
GO:0047234	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	raffinose:raffinose alpha-galactosyltransferase activity
GO:0047234	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	raffinose:raffinose alpha-D-galactosyltransferase activity
GO:0047234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raffinose-raffinose alpha-galactosyltransferase activity
REACT:R-HSA-5656356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC5A1 does not cotransport Glc and Na+ (Homo sapiens)
RHEA:68565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin
REACT:R-HSA-2512800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1:ligand is endocytosed (Homo sapiens)
RHEA:66825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate
RHEA:29151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)
GO:0047829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-nopaline dehydrogenase activity
GO:0047829	skos:prefLabel	"D-nopaline dehydrogenase"
GO:0047829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nopaline synthase activity
GO:0047829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NOS activity
GO:0047829	skos:altLabel	"nopaline dehydrogenase"
GO:0047829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)
GO:0047829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-nopaline + H2O + NADP(+) = 2-oxoglutarate + H(+) + L-arginine + NADPH
GO:0047829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)
GO:0047829	skos:altLabel	"D-nopaline synthase"
GO:0047829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-nopaline synthase activity
GO:0047829	skos:altLabel	"nopaline synthase"
GO:0047829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nopaline dehydrogenase activity
GO:0047829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-nopaline dehydrogenase"
GO:0047829	skos:altLabel	"NOS"
RHEA:48819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
REACT:R-BTA-430341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mig-2 recruits Migfilin to the cell-ECM adhesions (Bos taurus)
REACT:R-BTA-5654622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
REACT:R-GGA-173483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAMBI interferes with the interaction of type I receptor with type II receptor (Gallus gallus)
RHEA:37804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
GO:0005124	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	scavenger receptor ligand
GO:0005124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scavenger receptor binding
RHEA:10202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-butenoate + H(+) + NADH => butanoate + NAD(+)
REACT:R-DRE-6805740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 methylates TP53 (Danio rerio)
RHEA:33123	skos:prefLabel	"tetraprenyl-beta-curcumene synthase"
RHEA:33123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetraprenyl-beta-curcumene synthase"
RHEA:33123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate = (R)-tetraprenyl-beta-curcumene + diphosphate
REACT:R-HSA-9726621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR antagonists (Homo sapiens)
RHEA:21002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene
REACT:R-SSC-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Sus scrofa)
REACT:R-HSA-1222376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide from oxygen (Homo sapiens)
REACT:R-DME-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Drosophila melanogaster)
RHEA:32072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate
RHEA:38965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + leukotriene C4(out) + phosphate => ATP + H2O + leukotriene C4(in)
REACT:R-MMU-8948222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)
REACT:R-CFA-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Canis familiaris)
RHEA:20130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => adenine + D-ribose 5-phosphate
RHEA:53372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(17) in tRNA + NAD(+) = H(+) + NADH + uridine(17) in tRNA
REACT:R-DRE-2187309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer binds SP1 (Danio rerio)
RHEA:54530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate => aldehydo-D-ribose 5-phosphate
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbmoylphosphate synthetase activity
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl-phosphate synthase (ammonia) activity
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoylphosphate synthase activity
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoylphosphate synthase (ammonia)
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate synthase (ammonia) activity
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate synthetase I activity
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoylphosphate synthetase (ammonia) activity
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamylphosphate synthetase activity
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbon-dioxide--ammonia ligase activity
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamylphosphate synthetase I
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate synthetase (ammonia) activity
GO:0004087	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CPS I activity
RHEA:50860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
RHEA:68050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine => [protein]-D-aspartate + S-adenosyl-L-methionine
RHEA:29115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinone-8 + NADPH = menaquinol-8 + NADP(+)
RHEA:61539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:54219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O
RHEA:36376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamoyl phosphate + H2O => carbamoyl adenylate + diphosphate + phosphate
RHEA:36589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldono-1,5-lactone + H(+) + NADPH => an aldopyranose + NADP(+)
RHEA:35979	skos:prefLabel	"verruculogen prenyltransferase"
RHEA:35979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"verruculogen prenyltransferase"
RHEA:35979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + verruculogen = diphosphate + fumitremorgin A
RHEA:26474	skos:altLabel	"D-galactosyl-beta1->4-L-rhamnose phosphorylase"
RHEA:26474	skos:altLabel	"GalRhaP"
RHEA:26474	skos:prefLabel	"beta-D-galactosyl-(1->4)-L-rhamnose phosphorylase"
RHEA:26474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-D-galactosyl-(1->4)-L-rhamnose phosphorylase"
RHEA:26474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-L-rhamnose + phosphate = alpha-D-galactose 1-phosphate + L-rhamnopyranose
RHEA:61195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
REACT:R-CEL-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Caenorhabditis elegans)
REACT:R-DDI-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)
REACT:R-GGA-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Gallus gallus)
REACT:R-XTR-9688459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds HSP90:CDC37 (Xenopus tropicalis)
RHEA:67849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate
REACT:R-RNO-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Rattus norvegicus)
REACT:R-SSC-174425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Sus scrofa)
RHEA:59553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N',N'',N'''-tetraacetylchitotetraose + O2 => H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone
GO:0019141	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-pantolactone:NADP+ oxidoreductase (B-specific)
GO:0019141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantoyl-lactone reductase (B-specific) activity
GO:0019141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantolactone reductase (B-specific) activity
GO:0019141	skos:altLabel	"ketopantoyl lactone reductase"
GO:0019141	skos:altLabel	"2-dehydropantolactone reductase (B-specific)"
GO:0019141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydropantolactone reductase (Si-specific)"
GO:0019141	skos:altLabel	"2-ketopantoyl lactone reductase"
GO:0019141	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-oxopantoyl lactone reductase
GO:0019141	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ketopantoyl lactone reductase activity
GO:0019141	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-ketopantoyl lactone reductase activity
GO:0019141	skos:prefLabel	"2-dehydropantolactone reductase (Si-specific)"
GO:0019141	skos:altLabel	"2-dehydropantoyl-lactone reductase (B-specific)"
REACT:R-DME-75864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly Formed Phosphodiester Bond Stabilized and PPi Released (Drosophila melanogaster)
REACT:R-GGA-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Gallus gallus)
REACT:R-RNO-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Rattus norvegicus)
RHEA:66614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA
RHEA:23044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-tyrosine = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O
REACT:R-XTR-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Xenopus tropicalis)
REACT:R-RNO-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Rattus norvegicus)
GO:0016705	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous
GO:0016705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
RHEA:11175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine <=> (6S)-5,6,7,8-tetrahydrofolate + L-methionine
REACT:R-DME-1602374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Drosophila melanogaster)
REACT:R-XTR-5625784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Xenopus tropicalis)
RHEA:71741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate(out) + 2-oxoglutarate(in) => 2-oxoadipate(in) + 2-oxoglutarate(out)
RHEA:49748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NADP(+) + proviolacein
RHEA:10237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2-coumarate + UDP-alpha-D-glucose => H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP
REACT:R-HSA-9762097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYC binds the NFE2L2 promoter (Homo sapiens)
RHEA:48329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))
REACT:R-SSC-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Sus scrofa)
REACT:R-RNO-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Rattus norvegicus)
REACT:R-CFA-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
REACT:R-CFA-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Canis familiaris)
GO:0140449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	centromere nuclear envelope tether activity
GO:0140449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	centromere nuclear envelope anchor activity
GO:0140449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear envelope-centromere tether activity
GO:0140449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	centromere-inner nuclear envelope anchor activity
GO:0140449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromosome, centromeric region-nuclear envelope anchor activity
GO:0140449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	centromere-inner nuclear envelope tether activity
GO:0140449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	centromere-nuclear envelope anchor activity
GO:0140449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear envelope-centromere anchor activity
GO:0102768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanidin synthase activity
REACT:R-XTR-77323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Xenopus tropicalis)
REACT:R-HSA-6809393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)
REACT:R-RNO-5690845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNIPs bind TNFAIP3 (A20) (Rattus norvegicus)
RHEA:71253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylulose => L-xylopyranose
REACT:R-DRE-193669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds to p75NTR:NRIF (Danio rerio)
REACT:R-CEL-2530445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD59 inhibits MAC formation (Caenorhabditis elegans)
REACT:R-RNO-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Rattus norvegicus)
RHEA:15681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase"
RHEA:15681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) = (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH
RHEA:15681	skos:altLabel	"carboxymethylhydroxymuconic semialdehyde dehydrogenase"
RHEA:15681	skos:prefLabel	"5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase"
RHEA:14155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP => 17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine
RHEA:47404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH
RHEA:11657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-proline => AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]
RHEA:23659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate <=> 3-carboxy-cis,cis-muconate + H(+)
RHEA:51304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-DRE-6800298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF dimer binds MET (Danio rerio)
RHEA:24080	skos:altLabel	"tryptophanyl-transfer ribonucleate synthetase"
RHEA:24080	skos:altLabel	"TrpRS"
RHEA:24080	skos:altLabel	"tryptophanyl-tRNA synthetase"
RHEA:24080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan--tRNA ligase"
RHEA:24080	skos:altLabel	"tryptophan translase"
RHEA:24080	skos:altLabel	"tryptophanyl ribonucleic synthetase"
RHEA:24080	skos:altLabel	"L-tryptophan-tRNA(Trp) ligase (AMP-forming)"
RHEA:24080	skos:altLabel	"tryptophanyl-transfer RNA synthetase"
RHEA:24080	skos:altLabel	"tryptophanyl-transfer ribonucleic acid synthetase"
RHEA:24080	skos:prefLabel	"tryptophan--tRNA ligase"
RHEA:24080	skos:altLabel	"tryptophanyl-transfer ribonucleic synthetase"
RHEA:24080	skos:altLabel	"tryptophanyl-tRNA synthase"
RHEA:24080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)
REACT:R-DRE-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Danio rerio)
REACT:R-RNO-6807557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX4, NOX5 reduce O2 to O2.- (Rattus norvegicus)
REACT:R-GGA-9014420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the phagocytic vesicle membrane (Gallus gallus)
RHEA:68584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-tryptophan(out) = ADP + H(+) + L-tryptophan(in) + phosphate
REACT:R-SCE-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Saccharomyces cerevisiae)
REACT:R-BTA-8867240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPCAM binds itself to form homotypic cell adhesion (Bos taurus)
REACT:R-CFA-1433456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs (Canis familiaris)
REACT:R-RNO-388833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CTLA-4 (Rattus norvegicus)
RHEA:54220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-all-trans-1,2-dihydro-neurosporene = all-trans-neurosporene + H2O
REACT:R-BTA-2730837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-10Y-NTAL (Bos taurus)
REACT:R-SSC-202703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD47 binds SIRP (Sus scrofa)
RHEA:52510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:42738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine
REACT:R-CFA-6804596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1:CYCS binds APIP (Canis familiaris)
RHEA:22739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formimidoyltetrahydrofolate + 2 H(+) <=> 5,10-methenyltetrahydrofolate + NH4(+)
RHEA:64363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 <=> (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O
REACT:R-GGA-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Gallus gallus)
REACT:R-CEL-5649801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)
REACT:R-MMU-5686924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Mus musculus)
REACT:R-BTA-879934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SHC1 is mediated by Y593 of the common beta chain (Bos taurus)
REACT:R-GGA-8939706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) polyubiquitinates RUNX2 (Gallus gallus)
RHEA:19291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sucrose => H2O + sucrose 6(F)-phosphate
REACT:R-DME-5654631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PPTN11 (Drosophila melanogaster)
REACT:R-RNO-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)
RHEA:15595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amicoumacin A + phosphate => amicoumacin A 2-phosphate + H2O
RHEA:59325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + O2 => D-xylono-1,5-lactone + H2O2
REACT:R-HSA-9665034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1 (Homo sapiens)
REACT:R-MMU-433104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACT co-transports trivalent citrate and a sodium ion (Mus musculus)
RHEA:11156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valine dehydrogenase (NADP(+))"
RHEA:11156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-valine + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)
RHEA:11156	skos:prefLabel	"valine dehydrogenase (NADP(+))"
REACT:R-DRE-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Danio rerio)
RHEA:52845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + UDP-alpha-D-glucose => 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP
REACT:R-CEL-2028583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS2 (Caenorhabditis elegans)
RHEA:15265	skos:altLabel	"pyridoxine 5-phosphate phospho lyase"
RHEA:15265	skos:prefLabel	"pyridoxine 5'-phosphate synthase"
RHEA:15265	skos:altLabel	"PNP synthase"
RHEA:15265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxine 5'-phosphate synthase"
RHEA:15265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate
RHEA:12666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-deoxystreptamine antibiotic + acetyl-CoA => an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)
RHEA:21491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)
REACT:R-CFA-6814121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL binds G-protein beta and TRiC/CCT (Canis familiaris)
REACT:R-CEL-199863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT can phosphorylate NR4A1 (NUR77) (Caenorhabditis elegans)
REACT:R-DRE-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Danio rerio)
REACT:R-HSA-375340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 62 mediated neuronal gap junction communication (Homo sapiens)
REACT:R-MMU-2161951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)
RHEA:11723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 2 H2O + N-methylhydantoin <=> ADP + 2 H(+) + N-carbamoylsarcosine + phosphate
RHEA:44726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-fatty aldehyde + H(+) + NADPH => 2,3-saturated fatty aldehyde + NADP(+)
REACT:R-BTA-9678737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR1:TYK2 binds TYK2 inhibitors (Bos taurus)
RHEA:46898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)
REACT:R-XTR-8951676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TEADs and YAP1 (Xenopus tropicalis)
REACT:R-HSA-9705738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)
REACT:R-SSC-8851900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1-2 bound to MET recruits GRB2:SOS1 (Sus scrofa)
RHEA:50734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:12690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 mycothiol + NAD(+) => H(+) + mycothione + NADH
REACT:R-MMU-77590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CstF to the CPSF Bound Pre-mRNA (Mus musculus)
RHEA:23397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phloretin => 1,3,5-trihydroxybenzene + H(+) + phloretate
REACT:R-HSA-9024159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe) (Homo sapiens)
RHEA:11621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-amino-4-chloropent-4-enoate => 2-oxopent-4-enoate + chloride + H(+) + NH4(+)
RHEA:43597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde
REACT:R-HSA-8855711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Homo sapiens)
GO:0120092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O
GO:0120092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crotonyl-CoA hydratase activity
GO:0140753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linear 1,3-beta-D-glucan synthase activity
REACT:R-DME-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Drosophila melanogaster)
REACT:R-RNO-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Rattus norvegicus)
REACT:R-HSA-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Homo sapiens)
RHEA:13049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate = D-fructuronate
REACT:R-MMU-450325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-FOS activation by phospho ERK1/2 (Mus musculus)
REACT:R-BTA-174251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Bos taurus)
REACT:R-SSC-5607736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 oligomerizes (Sus scrofa)
RHEA:63237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin => 6-O-adenylylstreptomycin + diphosphate
REACT:R-DRE-419426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cannabinoid receptors can bind cannabinoids (Danio rerio)
REACT:R-CFA-5689972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)
REACT:R-GGA-212642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamine transport into neurons (Gallus gallus)
RHEA:27888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-AMP + H(+) => 2',3'-cyclophospho-AMP + H2O
REACT:R-SSC-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Sus scrofa)
RHEA:57319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cytidine 5'-diphosphoramidate <=> ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)
REACT:R-CEL-9755937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces LAN to 24,25-dhLAN (Caenorhabditis elegans)
RHEA:44775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)
RHEA:54601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + octanoyl-CoA => 2-hydroxyoctanoyl-CoA + CO2 + succinate
RHEA:42929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine
REACT:R-RNO-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Rattus norvegicus)
RHEA:51677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [protein]-dithiol + 2 AH2 + H(+) + sulfite
RHEA:50021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)
REACT:R-CFA-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Canis familiaris)
REACT:R-RNO-8937113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)
REACT:R-MMU-5686578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates ABL1 (Mus musculus)
REACT:R-RNO-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Rattus norvegicus)
RHEA:11715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:72085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-beta-D-ribose 1''-phosphate + H(+) => ADP-beta-D-ribose 1'',2''-cyclic phosphate + H2O
RHEA:27357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide + S-adenosyl-L-methionine = iodomethane + S-adenosyl-L-homocysteine
RHEA:37992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocopherol + S-adenosyl-L-methionine => beta-tocopherol + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-8850961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREX2 binds PTEN and inhibits it (Homo sapiens)
REACT:R-XTR-5693580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD52 with the RPA complex at resected DNA DSBs (Xenopus tropicalis)
RHEA:63162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoate + taurine => H2O + N-(15Z-tetracosenoyl)-taurine
REACT:R-SSC-5617816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A  (Sus scrofa)
REACT:R-CEL-75886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Caenorhabditis elegans)
REACT:R-RNO-8938930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF2 (Rattus norvegicus)
RHEA:10299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + NADP(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH
RHEA:54092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)
GO:0046538	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerate phosphomutase (diphosphoglycerate cofactor) activity
GO:0046538	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGAM-d
GO:0046538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
GO:0050228	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-amino-4-hydroxypteridine aminohydrolase activity
GO:0050228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pterin deaminase activity
GO:0050228	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acrasinase activity
REACT:R-XTR-5662692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is oxidized to dopaquinone by TYR (Xenopus tropicalis)
RHEA:34521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP => N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine
RHEA:66358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+)
RHEA:63878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2
REACT:R-MMU-8875591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK7 activates RAC1 (Mus musculus)
GO:0031829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 4 receptor binding
GO:0031829	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 4 serotonin receptor ligand
GO:0031829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 4 serotonin receptor binding
REACT:R-XTR-8954468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Xenopus tropicalis)
GO:0140681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36me2/H3K36me3 demethylase activity
GO:0140681	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K36me2 demethylase activity
GO:0140681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-tri/dimethyl-lysine-36 demethylase activity
GO:0140681	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone H3K36me3 demethylase activity
REACT:R-HSA-168405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD oligomer recruites RIP2 (RICK) (Homo sapiens)
GO:0015349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyroid hormone transmembrane transporter activity
RHEA:46471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O <=> ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate
REACT:R-SPO-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)
RHEA:49432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + lithocholoyl-CoA = choloyl-CoA + lithocholate
REACT:R-SSC-9023909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3PO hydrolyzes cleaved passenger strand (Sus scrofa)
RHEA:11694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + NADP(+) => NAD(+) + NADPH
RHEA:60714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic aldehyde + H(+) + NADH => (+)-artemisinic alcohol + NAD(+)
RHEA:44040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
REACT:R-SCE-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Saccharomyces cerevisiae)
REACT:R-XTR-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Xenopus tropicalis)
REACT:R-DRE-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Danio rerio)
REACT:R-HSA-204824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Ang4 (Homo sapiens)
GO:0035605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-cysteine S-nitrosylase activity
GO:0035605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-nitrosylase activity
GO:0035605	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein nitrosylase activity
RHEA:32014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (+)-T-muurolol + diphosphate
REACT:R-SSC-354087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2 to p-PTK2 (Sus scrofa)
RHEA:72656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine + NADPH + O2 => 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)
RHEA:13082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin amide + H2O => biotin + NH4(+)
REACT:R-CFA-110243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of 8-oxoguanine by OGG1 glycosylase (Canis familiaris)
REACT:R-RNO-201685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin is released from the destruction complex (Rattus norvegicus)
REACT:R-MMU-1254251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds YAP1 (Mus musculus)
REACT:R-CFA-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Canis familiaris)
REACT:R-HSA-934559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)
RHEA:43691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate <=> L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate
REACT:R-DRE-429698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKD1,2,3 phosphorylates CERT1-2 (Danio rerio)
REACT:R-CEL-3928640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs phosphorylate MLC (Caenorhabditis elegans)
REACT:R-CFA-5682863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF168 binds DNA DSBs (Canis familiaris)
RHEA:18100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pteridine-2,4,6,7-tetrol <=> H(+) + xanthine-8-carboxylate
REACT:R-CFA-202466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Bcl10 to CARMA1 (Canis familiaris)
RHEA:42219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA
RHEA:49015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin C + H(+) + NADH + O2 <=> aurachin C epoxide + H2O + NAD(+)
RHEA:42205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + NAD(+) => 11-dehydrocorticosterone + H(+) + NADH
REACT:R-CFA-451418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates IRAK1 (Canis familiaris)
GO:1901691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proton binding
GO:1901691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen ion binding
REACT:R-XTR-2484965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII binds Integrin alpha1beta1 (Xenopus tropicalis)
REACT:R-CFA-8876283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Canis familiaris)
RHEA:31310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:28509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->6)-lipid IVA + ATP <=> 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)
REACT:R-SSC-8954398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLD6 dimer hydrolyses cardiolipin to PA and PG (Sus scrofa)
REACT:R-DRE-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Danio rerio)
RHEA:17952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-1H-quinolin-4-one + O2 <=> CO + H(+) + N-formylanthranilate
REACT:R-DDI-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Dictyostelium discoideum)
REACT:R-DRE-212252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Danio rerio)
REACT:R-HSA-3108203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
REACT:R-CFA-167419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex releases GDP (Canis familiaris)
REACT:R-MMU-352103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Mus musculus)
RHEA:44185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 7-phosphate => 2-epi-5-epi-valiolone + phosphate
REACT:R-SPO-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Schizosaccharomyces pombe)
REACT:R-HSA-9613565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKAA2 dissociate from p-PLINs:HSPA8 (Homo sapiens)
REACT:R-DRE-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Danio rerio)
REACT:R-MMU-9036301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Mus musculus)
RHEA:46873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB
REACT:R-SSC-201630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Acinus (Sus scrofa)
REACT:R-CEL-201630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Acinus (Caenorhabditis elegans)
REACT:R-GGA-3234094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TFAP2C with SUMO1 (Gallus gallus)
RHEA:17512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)
REACT:R-BTA-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Bos taurus)
RHEA:13791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose
RHEA:10140	skos:altLabel	"prostaglandin-D2 11-ketoreductase"
RHEA:10140	skos:altLabel	"prostaglandin-F synthetase"
RHEA:10140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"prostaglandin-F synthase"
RHEA:10140	skos:altLabel	"PGD2 11-ketoreductase"
RHEA:10140	skos:prefLabel	"prostaglandin-F synthase"
RHEA:10140	skos:altLabel	"prostaglandin-D2 11-reductase"
RHEA:10140	skos:altLabel	"PGF synthetase"
RHEA:10140	skos:altLabel	"prostaglandin 11-ketoreductase"
RHEA:10140	skos:altLabel	"prostaglandin-D2 ketoreductase"
RHEA:10140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2
REACT:R-HSA-8862084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PILRA,PILRB bind CD99 (Homo sapiens)
REACT:R-HSA-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Homo sapiens)
REACT:R-MMU-193646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF binding to p75NTR inactivates RHOA (Mus musculus)
RHEA:13320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-tartrate + H(+) <=> (R)-glycerate + CO2
RHEA:36670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine
REACT:R-CEL-433131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC1 co-transports dicarboxylic acids and a sodium ion (Caenorhabditis elegans)
RHEA:68239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + Na(+)(in) <=> L-glutamine(out) + Na(+)(out)
RHEA:56730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dihydroxy-all-trans-beta-carotene + A + H2O => 4-hydroxy-all-trans-beta-carotene + AH2 + O2
REACT:R-GGA-353318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite to the lesion by Pol kappa (Gallus gallus)
RHEA:16094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)
RHEA:15554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4-bisphosphate + H2O => 1D-myo-inositol 4-phosphate + phosphate
REACT:R-SPO-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Schizosaccharomyces pombe)
REACT:R-SSC-351876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of occludin (Sus scrofa)
REACT:R-HSA-9620717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)
REACT:R-MMU-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Mus musculus)
REACT:R-RNO-5625424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The retrograde IFT train dissociates (Rattus norvegicus)
REACT:R-HSA-1606327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and release of IRF3  (Homo sapiens)
RHEA:58455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-GGA-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Gallus gallus)
RHEA:19756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + diphthine-[translation elongation factor 2] + NH4(+) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)
RHEA:62078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-galactono-1,5-lactone + H(+) + NADH => D-galactose 6-phosphate + NAD(+)
RHEA:50974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2
RHEA:28390	skos:prefLabel	"fructoselysine 3-epimerase"
RHEA:28390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-psicosyl)-L-lysine = N(6)-(D-fructosyl)-L-lysine
RHEA:28390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructoselysine 3-epimerase"
REACT:R-MMU-9693978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Small molecule inhibitor binds RIPK1, RIPK3 (Mus musculus)
RHEA:20286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate => alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine
REACT:R-BTA-140599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Bos taurus)
REACT:R-XTR-5696947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP47 deubiquitinates POLB (Xenopus tropicalis)
REACT:R-BTA-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Bos taurus)
RHEA:32552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => (S)-alpha-terpineol + diphosphate
REACT:R-BTA-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Bos taurus)
REACT:R-BTA-5634228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 is cleaved by caspases (Bos taurus)
RHEA:57819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + guanine
REACT:R-SSC-5687112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 is degraded by the 26S proteasome (Sus scrofa)
REACT:R-CFA-3134804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING ubiquitination by TRIM32 or TRIM56 (Canis familiaris)
REACT:R-CFA-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Canis familiaris)
REACT:R-CFA-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)
GO:0008843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endochitinase activity
RHEA:23371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phenylglyoxylate <=> benzaldehyde + CO2
RHEA:59327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + O2 <=> D-xylono-1,5-lactone + H2O2
REACT:R-RNO-6801762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A oligomerize to form a pore complex (Rattus norvegicus)
REACT:R-DRE-1067667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R (Danio rerio)
RHEA:27709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanine + D-serine <=> ADP + D-alanyl-D-serine + H(+) + phosphate
REACT:R-RNO-429441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK activation by SRC (Rattus norvegicus)
RHEA:30356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + methane + O2 => a quinone + H2O + methanol
REACT:R-MMU-8847995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERBB2 binds PTK6 (BRK) (Mus musculus)
REACT:R-XTR-6804253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates JMY (Xenopus tropicalis)
RHEA:27481	skos:prefLabel	"angelicin synthase"
RHEA:27481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:27481	skos:altLabel	"CYP71AJ4"
RHEA:27481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"angelicin synthase"
REACT:R-CFA-977629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of C2a/Bb by CR1 (Canis familiaris)
REACT:R-XTR-419011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectins (Xenopus tropicalis)
REACT:R-MMU-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Mus musculus)
REACT:R-HSA-2106614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex miRNA is loaded into Argonaute (Homo sapiens)
REACT:R-MMU-5655142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 binds POLH (Mus musculus)
REACT:R-DDI-1855200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Dictyostelium discoideum)
REACT:R-CEL-76052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIA To type 1 Promoter (Caenorhabditis elegans)
REACT:R-BTA-6803063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial LPS, PGN (Bos taurus)
REACT:R-DME-532603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin mediated activation of N-WASP (Drosophila melanogaster)
RHEA:54002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O
REACT:R-CFA-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Canis familiaris)
REACT:R-MMU-5626549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAPs bind CALM1 (Mus musculus)
REACT:R-RNO-804969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B1 hydrogenates E1 to EST17b (Rattus norvegicus)
REACT:R-HSA-917814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Homo sapiens)
RHEA:62340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-malbrancheamide C + FADH2
RHEA:18663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-ornithine + NADPH + pyruvate => H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+)
REACT:R-RNO-1169402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of E2 conjugating enzymes (Rattus norvegicus)
RHEA:70955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-glutamate(in) = H(+)(out) + L-glutamate(out)
REACT:R-HSA-4419986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL (Homo sapiens)
REACT:R-DDI-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Dictyostelium discoideum)
REACT:R-RNO-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
RHEA:35339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyicosanoyl-CoA + NADP(+) = 3-oxoeicosanoyl-CoA + H(+) + NADPH
REACT:R-HSA-73598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Homo sapiens)
GO:0001161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intronic transcription regulatory region sequence-specific DNA binding
GO:0001161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	intronic transcription regulatory region DNA binding
REACT:R-BTA-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Bos taurus)
RHEA:52376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) = (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)
GO:0102525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity
GO:0031854	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	orexigenic neuropeptide QRFP receptor ligand
GO:0031854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	orexigenic neuropeptide QRFP receptor binding
REACT:R-BTA-5684875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATR:ATRIP to RPA at resected DNA DSBs (Bos taurus)
RHEA:51772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + phlorisobutanophenone = 4-prenylphlorisobutanophenone + diphosphate
REACT:R-CEL-1433415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 (Caenorhabditis elegans)
GO:0003842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta1-pyrroline-5-carboxylate dehydrogenase activity
GO:0003842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-pyrroline-5-carboxylate dehydrogenase activity
GO:0003842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity
GO:0003842	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1-pyrroline dehydrogenase
GO:0003842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrroline-5-carboxylic acid dehydrogenase activity
GO:0003842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrroline-5-carboxylate dehydrogenase activity
GO:0003842	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity
REACT:R-BTA-140748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Bos taurus)
REACT:R-HSA-5601929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown nuclease cleaves cleaved transposon RNA in 6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)
REACT:R-BTA-174425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Bos taurus)
REACT:R-DME-8858369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVRL1 binds BMP9,BMP10 (Drosophila melanogaster)
RHEA:69503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + NAD(+) <=> ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide
REACT:R-CEL-1855221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
REACT:R-HSA-9611851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 bind ADR,NAd (Homo sapiens)
RHEA:46649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxy-3-oxochol-4-en-22-oyl-CoA => androst-4-ene-3,17-dione + propanoyl-CoA
REACT:R-HSA-447030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NrCAM binds Ankyrin-G (Homo sapiens)
REACT:R-BTA-5690785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 binds Ub-HCFC1 (Bos taurus)
REACT:R-GGA-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Gallus gallus)
REACT:R-DRE-8876366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL translocates from endosome lumen to lysosome lumen (Danio rerio)
REACT:R-HSA-5696816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA ligase complex ligates tRNA exons (Homo sapiens)
RHEA:69012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane-3beta,17beta-diol + NADP(+)
GO:0015926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosidase activity
GO:0010340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyl-O-methyltransferase activity
REACT:R-RNO-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Rattus norvegicus)
REACT:R-SSC-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Sus scrofa)
RHEA:28692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + a ubiquinone => a ubiquinol + orotate
GO:0033191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	macrophomate synthase activity
REACT:R-DME-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Drosophila melanogaster)
REACT:R-SSC-379464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DOPAC to form HVA (Sus scrofa)
RHEA:69171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + spermine monoaldehyde <=> 2 H(+) + N-(2-carboxyethyl)spermidine + NADH
REACT:R-RNO-5218847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 binds NCK (Rattus norvegicus)
RHEA:63256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)
RHEA:59623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(4-aminobutanoyl)-L-lysine <=> 4-aminobutanoate + L-lysine
RHEA:65130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA
RHEA:55992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
RHEA:66062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + kynurenate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine
REACT:R-DRE-354149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
REACT:R-PFA-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Plasmodium falciparum)
REACT:R-HSA-3791155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminin-322 degradation by MMP14 (Homo sapiens)
REACT:R-HSA-193997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B1 oxidises 11DCORT (Homo sapiens)
REACT:R-HSA-8953336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of EXTL1 (Homo sapiens)
RHEA:16578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ATP + H(+) => P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate
RHEA:72300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) => 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)
REACT:R-HSA-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Homo sapiens)
GO:0102418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin-7-O-glucoside 1,6-glucosyltransferase activity
RHEA:25616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> terpentedienyl diphosphate
RHEA:61886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
RHEA:42166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2
REACT:R-BTA-8987012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)
REACT:R-CFA-8937177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD binds ARNT (Canis familiaris)
RHEA:44902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactonate + H(+) => D-galactono-1,4-lactone + H2O
REACT:R-MMU-8950441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Mus musculus)
RHEA:56742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalGb3Cer + H(+) + UDP => globoside Gb3Cer + UDP-alpha-D-galactose
REACT:R-GGA-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Gallus gallus)
RHEA:41813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-[ACP] + H(+) + NADPH => butanoyl-[ACP] + NADP(+)
REACT:R-CEL-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Caenorhabditis elegans)
REACT:R-HSA-380198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)
REACT:R-RNO-3222259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHF20 binds TP53 dimethylated on K370 and K382 (Rattus norvegicus)
REACT:R-DRE-5205822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-18 (H3R17) of histone H3 (Danio rerio)
REACT:R-BTA-9750555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Bos taurus)
REACT:R-XTR-418172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB2 (Xenopus tropicalis)
REACT:R-CEL-9620515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2B,EP300 acetylate FOXO3 under oxidative stress (Caenorhabditis elegans)
REACT:R-CFA-176474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Canis familiaris)
REACT:R-XTR-8951486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C4b (Xenopus tropicalis)
RHEA:41584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-O-dimethylallyl-L-tyrosine synthase"
RHEA:41584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-tyrosine = 4-O-dimethylallyl-L-tyrosine + diphosphate
RHEA:41584	skos:prefLabel	"4-O-dimethylallyl-L-tyrosine synthase"
REACT:R-HSA-9645608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
REACT:R-SSC-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Sus scrofa)
EC:3.2.1.158	skos:prefLabel	"alpha-agarase"
EC:3.2.1.158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-agarase"
EC:3.2.1.158	skos:altLabel	"agarase A33"
REACT:R-GGA-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Gallus gallus)
REACT:R-SSC-2534378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hv1 Mediated H+ Permeability (Sus scrofa)
GO:0018482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-formylbenzenesulfonate dehydrogenase activity
GO:0018482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-formylbenzenesulphonate dehydrogenase activity
GO:0018482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toluene-sulfonate aldehyde dehydrogenase activity
GO:0018482	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-formylbenzenesulfonate:NAD+ oxidoreductase activity
RHEA:21423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin I2 <=> 15-dehydro-prostaglandin I2 + H(+) + NADPH
RHEA:46756	skos:prefLabel	"palmitoyl-[glycerolipid] 7-desaturase"
RHEA:46756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:46756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"palmitoyl-[glycerolipid] 7-desaturase"
RHEA:18295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + oxalyl-CoA => ATP + CoA + oxalate
GO:0140341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylethanolamine floppase activity (cytosolic to exoplasmic leaftlet)
GO:0140341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylethanolamine floppase activity
GO:0033918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kappa-carrageenan 4-beta-D-glycanohydrolase activity
GO:0033918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kappa-carrageenase activity
GO:0033918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity
REACT:R-HSA-3781926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective PMM2 does not isomerise Man6P to Man1P (Homo sapiens)
REACT:R-DRE-450422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP recruits RNA degradation activities (Danio rerio)
RHEA:22002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,5-lactone + H(+) + NADPH => D-xylose + NADP(+)
RHEA:65505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine
RHEA:63299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine
REACT:R-RNO-5690808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3, SENP8 cleave NEDD8 (Rattus norvegicus)
REACT:R-MMU-6799777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind PPP1R13B or TP53BP2 (Mus musculus)
REACT:R-SSC-8875816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds activated MET receptor (Sus scrofa)
GO:0018847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-pinene lyase activity
RHEA:15208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphooligosaccharide + H2O <=> a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)
REACT:R-XTR-2314686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS2 (Xenopus tropicalis)
REACT:R-RNO-1250383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Rattus norvegicus)
REACT:R-RNO-2984220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1:CCNB phosphorylates NEK9 (Rattus norvegicus)
REACT:R-SCE-3322014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)
REACT:R-BTA-8944246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXI (Bos taurus)
REACT:R-HSA-8956140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 and UBD bind NUB1 and the 26S proteasome (Homo sapiens)
RHEA:41964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + O2 = (2E)-butenoyl-CoA + H2O2
REACT:R-GGA-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Gallus gallus)
REACT:R-BTA-9757574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDL (Bos taurus)
RHEA:64171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethyl-L-serine <=> (2S)-2-aminobutanoate + formaldehyde
REACT:R-SSC-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Sus scrofa)
REACT:R-XTR-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Xenopus tropicalis)
REACT:R-RNO-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Rattus norvegicus)
RHEA:63602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine + neocasomorphin-(1-5) => H2O + neocasomorphin
REACT:R-XTR-9603991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Xenopus tropicalis)
RHEA:18722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => diphosphate + ent-13-epi-manoyl oxide
RHEA:45302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + H(+) + phosphocholine => an N-(acyl)-sphingosylphosphocholine + H2O
RHEA:56110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => genistein + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:27905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H2O + ubiquinone-0 <=> 1,3,7-trimethylurate + ubiquinol-0
GO:0140756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of proteasome
REACT:R-RNO-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Rattus norvegicus)
RHEA:21621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NAD(+) => FMN + 2 H(+) + NADH
REACT:R-BTA-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Bos taurus)
RHEA:27773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Rattus norvegicus)
REACT:R-RNO-8934446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC phosphorylates SHC1 (Rattus norvegicus)
RHEA:60344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
RHEA:60344	skos:prefLabel	"[histone H4]-lysine(20) N-methyltransferase"
RHEA:60344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H4]-lysine(20) N-methyltransferase"
REACT:R-HSA-873922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 by JAK kinases (Homo sapiens)
REACT:R-HSA-8875443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates LRIG1 (Homo sapiens)
REACT:R-CEL-9705713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
RHEA:54171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:11093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADH
REACT:R-HSA-5655835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Homo sapiens)
REACT:R-DRE-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Danio rerio)
REACT:R-CEL-2395873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)
RHEA:55742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + oleuropein aglycone => H2O + oleuropein
REACT:R-BTA-6785213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer binds heparin (Bos taurus)
REACT:R-DRE-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Danio rerio)
REACT:R-DRE-1655831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 translocates to the nucleus (Danio rerio)
REACT:R-DME-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Drosophila melanogaster)
RHEA:22879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelamide + H2O <=> (R)-mandelate + NH4(+)
REACT:R-PFA-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)
REACT:R-DRE-2473584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP15 (Danio rerio)
REACT:R-BTA-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Bos taurus)
REACT:R-XTR-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Xenopus tropicalis)
REACT:R-GGA-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Gallus gallus)
RHEA:62408	skos:altLabel	"3-O-methylmannose polysaccharide 1-O-methyltransferase"
RHEA:62408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine = 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine
RHEA:62408	skos:prefLabel	"MMP 1-O-methyltransferase"
RHEA:62408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"MMP 1-O-methyltransferase"
REACT:R-RNO-8874078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Rattus norvegicus)
GO:0050507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity
GO:0050507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoxyl-UDPG glucosyltransferase activity
GO:0050507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoxyl-UDPG-glucosyltransferase activity
RHEA:35388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-7 + S-adenosyl-L-methionine => 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine
GO:0004350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
GO:0004350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamylphosphate reductase activity
GO:0004350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamyl-gamma-semialdehyde dehydrogenase activity
GO:0004350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-5-semialdehyde dehydrogenase activity
GO:0004350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate semialdehyde dehydrogenase activity
GO:0004350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-glutamylphosphate reductase activity
GO:0004350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamylphosphate reductase activity
GO:0004350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamyl phosphate reductase activity
GO:0004350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-phosphate reductase activity
GO:0004350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate-gamma-semialdehyde dehydrogenase activity
RHEA:58940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH = all-trans-lycopaoctaene + diphosphate + NAD(+)
REACT:R-GGA-5682896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3:ATG7 dimer binds ATG3 (Gallus gallus)
RHEA:65443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
REACT:R-CEL-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Caenorhabditis elegans)
RHEA:67598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + octadecanoyl-CoA
REACT:R-CFA-947535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Canis familiaris)
REACT:R-DRE-5649723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Danio rerio)
REACT:R-CFA-6807053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)
REACT:R-HSA-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Homo sapiens)
RHEA:20346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + NADP(+) => [thioredoxin]-disulfide + H(+) + NADPH
RHEA:38478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine
RHEA:68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin E1 <=> NADP(+) + prostaglandin F1
REACT:R-SSC-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Sus scrofa)
REACT:R-XTR-416358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) inhibits PI3K alpha (Xenopus tropicalis)
REACT:R-DME-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Drosophila melanogaster)
RHEA:64396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-sarcosine(out) + H(+)(out) = glycyl-sarcosine(in) + H(+)(in)
REACT:R-BTA-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Bos taurus)
REACT:R-GGA-5632677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH is internalized (Gallus gallus)
REACT:R-DRE-9026006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Danio rerio)
REACT:R-RNO-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Rattus norvegicus)
REACT:R-SCE-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Saccharomyces cerevisiae)
RHEA:41367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:70914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)
RHEA:69765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + 2 H(+) + NADH => a medium-chain fatty aldehyde + H2O + NAD(+)
REACT:R-RNO-2172433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIX degradation (Rattus norvegicus)
REACT:R-SCE-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Saccharomyces cerevisiae)
REACT:R-MMU-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Mus musculus)
RHEA:13690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + glycerol => glycerol 1-phosphate + H(+) + phosphate
REACT:R-MMU-8943007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Mus musculus)
REACT:R-HSA-9661820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bacterial GUSB hydrolyses BDG to BIL (Homo sapiens)
RHEA:27495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tricetin
RHEA:47026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+) => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O
REACT:R-BTA-168848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAK protein (Bos taurus)
REACT:R-BTA-352191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A8-mediated uptake of neutral amino acids (Bos taurus)
REACT:R-CFA-6797627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASPG hydrolyses L-Asn to L-Asp (Canis familiaris)
EC:3.4.22.69	skos:altLabel	"SARS coronavirus main protease"
EC:3.4.22.69	skos:altLabel	"3C-like protease"
EC:3.4.22.69	skos:prefLabel	"SARS coronavirus main proteinase"
EC:3.4.22.69	skos:altLabel	"3cLpro"
EC:3.4.22.69	skos:altLabel	"severe acute respiratory syndrome coronavirus main protease"
EC:3.4.22.69	skos:altLabel	"SARS-CoV 3CLpro enzyme"
EC:3.4.22.69	skos:altLabel	"coronavirus 3C-like protease"
EC:3.4.22.69	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"SARS coronavirus main proteinase"
REACT:R-PFA-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Plasmodium falciparum)
RHEA:52576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanoyl-CoA + NAD(+) = (2E)-hexenoyl-CoA + H(+) + NADH
REACT:R-GGA-9014296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GEFs activate RAC2 (Gallus gallus)
REACT:R-GGA-4755536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates RELA with SUMO3 (Gallus gallus)
REACT:R-CEL-9638078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from keratan sulfate (Caenorhabditis elegans)
REACT:R-HSA-1168459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lyn activates ERK (Homo sapiens)
REACT:R-CFA-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Canis familiaris)
REACT:R-HSA-5626982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)
RHEA:68193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + phytol => CoA + decanoate phytyl ester
RHEA:32579	skos:prefLabel	"(+)-beta-pinene synthase"
RHEA:32579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (1R,5R)-beta-pinene + diphosphate
RHEA:32579	skos:altLabel	"(+)-pinene cyclase"
RHEA:32579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-beta-pinene synthase"
REACT:R-CFA-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Canis familiaris)
RHEA:28897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine(out) + L-lysine(in) => cadaverine(in) + L-lysine(out)
GO:0097364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential
REACT:R-HSA-8959510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)
REACT:R-MMU-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Mus musculus)
RHEA:45804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydroxylamine + L-glutamate = ADP + L-glutamine hydroxamate + phosphate
REACT:R-CFA-174389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)
REACT:R-CFA-9704248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM4 binds CHRM4 antagonists (Canis familiaris)
RHEA:60638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate => N-(dodecanoyl)-sphing-4-enine-1-phosphocholine
RHEA:19899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADPH + 4 O2
REACT:R-PFA-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Plasmodium falciparum)
REACT:R-XTR-8944261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIII (Xenopus tropicalis)
RHEA:48479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1a (d18:1(4E)) + H2O <=> ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate
REACT:R-HSA-5423632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFXBO binds DNA (Homo sapiens)
REACT:R-MMU-170835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Mus musculus)
RHEA:53655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate
REACT:R-RNO-1250370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)
RHEA:70171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + pemetrexed(in) = H(+)(out) + pemetrexed(out)
GO:0102700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-thujene synthase activity
RHEA:29360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UMP => phosphate + uridine
RHEA:23509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O => (7R)-7-aminocephalosporanate + glutarate
REACT:R-PFA-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Plasmodium falciparum)
REACT:R-SSC-5654697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
RHEA:16530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + sulfate => adenosine 5'-phosphosulfate + phosphate
REACT:R-DRE-212269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Danio rerio)
REACT:R-RNO-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Rattus norvegicus)
GO:0016662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a cytochrome as acceptor"
GO:0016662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
GO:0016662	skos:prefLabel	"With a cytochrome as acceptor"
RHEA:38414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)
REACT:R-CEL-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Caenorhabditis elegans)
REACT:R-MMU-428609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type I Na+-coupled phosphate co-transport (Mus musculus)
RHEA:71138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-histidine(out) + Na(+)(out) <=> H(+)(out) + L-histidine(in) + Na(+)(in)
REACT:R-DME-389826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + NADPH + H+ => glycolate + NADP+ (Drosophila melanogaster)
RHEA:21667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenyl phosphate + H2O <=> 4-nitrophenol + H(+) + phosphate
REACT:R-XTR-420489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parathyroid hormone receptor can bind parathyroid hormone (Xenopus tropicalis)
REACT:R-RNO-201457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP2 binds to the receptor complex (Rattus norvegicus)
REACT:R-SCE-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Saccharomyces cerevisiae)
REACT:R-BTA-3364014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SET1 methyltransferase complex (Bos taurus)
RHEA:22153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + D-glucose => a ubiquinol + D-glucono-1,5-lactone
REACT:R-GGA-9667456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B bind desmopressin (Gallus gallus)
REACT:R-MMU-204364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO1 binds SLIT2 (Mus musculus)
REACT:R-SSC-9697747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at TNFR signaling complex (Sus scrofa)
RHEA:22154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + D-glucono-1,5-lactone => a ubiquinone + D-glucose
REACT:R-HSA-8941618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
REACT:R-SSC-1454822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I degradation by MMP1,2,8,13, PRSS2 (Sus scrofa)
REACT:R-XTR-5617182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates PLN (Xenopus tropicalis)
REACT:R-HSA-74372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Homo sapiens)
REACT:R-MMU-8847875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF1:GTP binds Golgin TRIP11 (Mus musculus)
GO:0050733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RS domain binding
REACT:R-BTA-6809263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Bos taurus)
RHEA:66041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-9626945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP acetylates FOXO1 (Homo sapiens)
REACT:R-MMU-177943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to EGF:EGFR complex (Mus musculus)
REACT:R-HSA-5358579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase delta polymerizes DNA across single stranded gap (Homo sapiens)
RHEA:31692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 => (9R)-hydroperoxy-(10E,12Z)-octadecadienoate
RHEA:55701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O => an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate
REACT:R-SSC-9647680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP1 cleaves GSDMD (Sus scrofa)
REACT:R-GGA-1234165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Gallus gallus)
REACT:R-CFA-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
REACT:R-CFA-9690449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 bind S1P (Canis familiaris)
RHEA:61787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-allulose <=> keto-L-fructose
REACT:R-DME-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Drosophila melanogaster)
RHEA:36653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + novobiocic acid + S-adenosyl-L-homocysteine => 8-desmethylnovobiocic acid + S-adenosyl-L-methionine
REACT:R-CFA-9708525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1:FBXL17 binds SCF(SKP2) complex (Canis familiaris)
REACT:R-DRE-4570553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO2,3 (Danio rerio)
RHEA:36773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose
GO:0042923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuropeptide binding
REACT:R-DME-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Drosophila melanogaster)
REACT:R-RNO-202724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-selectin binds P-selectin ligand (Rattus norvegicus)
RHEA:12385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + O2 => H2O2 + uracil
REACT:R-HSA-2752115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds CD44 (Homo sapiens)
REACT:R-BTA-8851929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Bos taurus)
RHEA:33703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine
REACT:R-CFA-8873923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 binds LPCAT1 and PC (Canis familiaris)
REACT:R-DRE-166538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The bound receptor dimerizes (Danio rerio)
RHEA:63114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ascofuranone => A + ascofuranol
REACT:R-DDI-264444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of phospho-COP1(Ser-387 ) (Dictyostelium discoideum)
REACT:R-DDI-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Dictyostelium discoideum)
RHEA:27999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine diphosphate => H(+) + phosphate + thiamine phosphate
RHEA:28474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate(in) + H(+)(in) = D-glucarate(out) + H(+)(out)
REACT:R-SSC-5683888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMCD1 binds GATA6, sequestering it (Sus scrofa)
REACT:R-XTR-190258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c binds to FGF (Xenopus tropicalis)
REACT:R-RNO-9654525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Rattus norvegicus)
RHEA:14930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADH
REACT:R-MMU-2730841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV (Mus musculus)
RHEA:14635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)
REACT:R-DRE-8850945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates PTEN (Danio rerio)
REACT:R-GGA-2230938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin:Haptoglobin:CD163 is endocytosed (Gallus gallus)
GO:0102123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A4 16alpha,17 epoxidase activity
REACT:R-HSA-6805022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP2 binds the heterodimer of MDM2 and MDM4 (Homo sapiens)
REACT:R-GGA-1254248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80:YAP1 complex to the nucleus (Gallus gallus)
REACT:R-XTR-9648983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Xenopus tropicalis)
RHEA:21526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-isopropylmalate + CoA + H(+) => 3-methyl-2-oxobutanoate + acetyl-CoA + H2O
RHEA:58361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[protein] + O2 => (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate
RHEA:29007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + Mn(2+)(in) = H(+)(out) + Mn(2+)(out)
REACT:R-XTR-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Xenopus tropicalis)
GO:0106059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (cytidine 56-2'-O)-methyltransferase
GO:0036200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosteroid 9-alpha-monooxygenase activity
GO:0036200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-ketosteroid 9alpha-hydroxylase activity
GO:0036200	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KshAB activity
REACT:R-BTA-202709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 dimerises (Bos taurus)
REACT:R-BTA-209087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)
RHEA:42493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 => 3'-N-debenzoyltaxol + A + H2O
GO:0050370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine N-hydroxylase activity
GO:0050370	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CYP79A1 activity
GO:0050370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine N-monooxygenase activity
GO:0050370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)
REACT:R-SSC-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Sus scrofa)
RHEA:27334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate + 2 H(+) + NADH + O2 => 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)
REACT:R-GGA-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Gallus gallus)
GO:0016881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide synthase activity
GO:0016881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acid-amino acid ligase activity
GO:0016881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acid--amino-acid ligases (peptide synthases)"
GO:0016881	skos:prefLabel	"Acid--amino-acid ligases (peptide synthases)"
REACT:R-MMU-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Mus musculus)
REACT:R-GGA-8852481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Gallus gallus)
RHEA:21010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH => diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+)
REACT:R-HSA-9031624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARC gene expression (Homo sapiens)
GO:0052840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol diphosphate tetrakisphosphate diphosphatase activity
RHEA:57119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
RHEA:31512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + H2O => chenodeoxycholate + CoA + H(+)
REACT:R-SSC-9005980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 binds IL21R:JAK1 (Sus scrofa)
REACT:R-SSC-1855176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Sus scrofa)
RHEA:54294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate => ATP + L-threonyl-[protein]
REACT:R-MMU-3322003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG1 complexed with GYS1-b (Mus musculus)
RHEA:34760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycerol 2-phosphate(out) + H2O => ADP + glycerol 2-phosphate(in) + H(+) + phosphate
RHEA:13961	skos:altLabel	"Mg-chelatase"
RHEA:13961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate
RHEA:13961	skos:prefLabel	"magnesium chelatase"
RHEA:13961	skos:altLabel	"protoporphyrin IX Mg-chelatase"
RHEA:13961	skos:altLabel	"Mg-protoporphyrin IX magnesio-lyase"
RHEA:13961	skos:altLabel	"protoporphyrin IX magnesium-chelatase"
RHEA:13961	skos:altLabel	"magnesium-protoporphyrin IX chelatase"
RHEA:13961	skos:altLabel	"magnesium-chelatase"
RHEA:13961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"magnesium chelatase"
RHEA:13961	skos:altLabel	"magnesium-protoporphyrin chelatase"
RHEA:13961	skos:altLabel	"Mg-protoporphyrin IX chelatase"
REACT:R-RNO-9640167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B exchanges GDP for GTP (Rattus norvegicus)
RHEA:38358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-phenyllactoyl-CoA <=> (E)-cinnamoyl-CoA + H2O
RHEA:43578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O
REACT:R-RNO-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Rattus norvegicus)
RHEA:48494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose
REACT:R-XTR-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Xenopus tropicalis)
GO:0043522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucine zipper domain binding
GO:0043522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucine zipper binding
RHEA:21606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde => styrene oxide
RHEA:35530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-ethylmaleimide + NADH <=> N-ethylsuccinimide + NAD(+)
REACT:R-MMU-1981128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Mus musculus)
REACT:R-CFA-9718394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide antagonists (Canis familiaris)
RHEA:53485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,11,17-trione + H(+) + NADPH => 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)
GO:0034027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(carboxyethyl)arginine beta-lactam-synthase activity
GO:0034027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity
GO:0034027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(2)-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminate + diphosphate + H(+)
GO:0034027	skos:altLabel	"beta-lactam synthetase"
GO:0034027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity
GO:0034027	skos:prefLabel	"(carboxyethyl)arginine beta-lactam-synthase"
GO:0034027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(carboxyethyl)arginine beta-lactam-synthase"
GO:0034027	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-lactam synthetase activity
RHEA:39817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate
REACT:R-HSA-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)
REACT:R-HSA-9022941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds GAD2 gene promoter (Homo sapiens)
REACT:R-RNO-391937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP/CysLT receptor can bind cysteinyl leukotrienes (Rattus norvegicus)
RHEA:24980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate
RHEA:24980	skos:prefLabel	"3-hydroxy-4-methylanthranilate adenylyltransferase"
RHEA:24980	skos:altLabel	"actinomycin synthase I"
RHEA:24980	skos:altLabel	"4-MHA-activating enzyme"
RHEA:24980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-4-methylanthranilate adenylyltransferase"
RHEA:53134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(1,4)-steroid + AH2 => A + a 3-oxo-Delta(4)-steroid
RHEA:55655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:17428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NADP(+) + pyruvate <=> acetyl-CoA + CO2 + NADPH
REACT:R-HSA-4341669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates (Homo sapiens)
REACT:R-BTA-9750617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC5 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
REACT:R-CFA-2744228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Canis familiaris)
REACT:R-RNO-6808487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)
RHEA:21490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+) => dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O
REACT:R-HSA-1168643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
REACT:R-BTA-351948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial recruitment of Drp1 (Bos taurus)
RHEA:70276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + raffinose => D-galactose + sucrose
GO:0042608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T cell receptor binding
GO:0042608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binding
GO:0042608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T lymphocyte receptor binding
GO:0042608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T-lymphocyte receptor binding
GO:0042608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T-cell receptor binding
REACT:R-XTR-4086410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates BORA (Xenopus tropicalis)
REACT:R-CFA-1169399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Canis familiaris)
RHEA:57844	skos:altLabel	"CYP82C4"
RHEA:57844	skos:prefLabel	"fraxetin 5-hydroxylase"
RHEA:57844	skos:altLabel	"fraxetin 5-monooxygenase"
RHEA:57844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fraxetin 5-hydroxylase"
RHEA:57844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fraxetin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)
RHEA:63897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspulvinone E + hnu => isoaspulvinone E
RHEA:14171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutaryl-CoA + phosphate => ATP + CoA + glutarate
RHEA:51057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + androst-4-ene-3,17-dione => AH2 + androsta-1,4-diene-3,17-dione
REACT:R-MMU-9028255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises EPA to PGH3 (Mus musculus)
RHEA:64441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycylglycyl-L-proline(out) + H(+)(out) => glycylglycyl-L-proline(in) + H(+)(in)
RHEA:54937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-[ACP] + H(+) + NADH => decanoyl-[ACP] + NAD(+)
GO:0140930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose:sodium symporter activity
REACT:R-BTA-904864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Bos taurus)
GO:0070740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin-glutamic acid ligase activity
GO:0070740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin-glutamate ligase activity
GO:0070740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin glutamylase activity
REACT:R-MMU-8848339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA5 hydrolyzes TAG (Mus musculus)
RHEA:26203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammelide + NH4(+) => ammeline + H(+) + H2O
RHEA:37534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-BTA-9731393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA, EDNRB bind non-selective ERAs (Bos taurus)
GO:0106294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase H202-forming activity
GO:0106294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 = H2O2 + NADP(+)
REACT:R-RNO-9018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds interacting proteins at the endosome membrane (Rattus norvegicus)
RHEA:68377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-asparagine => 2-oxosuccinamate + glycine
GO:0102879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-thujopsene synthase activity
REACT:R-DME-8852167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:Catecholamine binds ARRB1, ARRB2 (Drosophila melanogaster)
GO:0047338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylose 1-phosphate uridylyltransferase activity
GO:0047338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xylose-1-phosphate uridylyltransferase activity
GO:0047338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-xylose pyrophosphorylase activity
GO:0047338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xylose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-xylose
GO:0047338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridylyltransferase, xylose 1-phosphate
GO:0047338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UTP--xylose-1-phosphate uridylyltransferase"
GO:0047338	skos:altLabel	"xylose-1-phosphate uridylyltransferase"
GO:0047338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP:xylose-1-phosphate uridylyltransferase activity
GO:0047338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoxylose pyrophosphorylase activity
GO:0047338	skos:prefLabel	"UTP--xylose-1-phosphate uridylyltransferase"
GO:0047338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity
GO:0047338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP-xylose-1-phosphate uridylyltransferase activity
RHEA:32634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin D + H(+) + NADPH + O2 <=> erythromycin C + H2O + NADP(+)
RHEA:65540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 + H2O = an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose
REACT:R-RNO-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Rattus norvegicus)
REACT:R-HSA-549475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of NR1D1 (REV-ERBA) (Homo sapiens)
REACT:R-XTR-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Xenopus tropicalis)
RHEA:66176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurochenodeoxycholate 3-sulfate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)
REACT:R-SSC-5610726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The IFT-A complex recruits TULP3 (Sus scrofa)
REACT:R-DME-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Drosophila melanogaster)
REACT:R-MMU-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Mus musculus)
REACT:R-HSA-8848930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 translocates to the nucleus (Homo sapiens)
RHEA:10336	skos:altLabel	"citrate(isocitrate) hydro-lyase"
RHEA:10336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate = D-threo-isocitrate
RHEA:10336	skos:altLabel	"cis-aconitase"
RHEA:10336	skos:altLabel	"aconitase"
RHEA:10336	skos:altLabel	"citrate hydro-lyase"
RHEA:10336	skos:prefLabel	"aconitate hydratase"
RHEA:10336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aconitate hydratase"
REACT:R-DME-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Drosophila melanogaster)
RHEA:46955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:69647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + quercetin 4'-O-beta-D-glucoside = beta-D-glucose + quercetin
GO:0047159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkenylglycerophosphocholine O-acyltransferase activity
GO:0047159	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity
REACT:R-CFA-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Canis familiaris)
REACT:R-MMU-9638125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G1P to G6P (Mus musculus)
REACT:R-DDI-2066788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Dictyostelium discoideum)
REACT:R-GGA-5654705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
GO:0097110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scaffold protein binding
RHEA:38716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + choline(out) + H2O => ADP + choline(in) + H(+) + phosphate
EC:2.4.2.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanosine phosphorylase"
EC:2.4.2.15	skos:prefLabel	"guanosine phosphorylase"
EC:3.4.24.-	skos:prefLabel	"Metalloendopeptidases"
EC:3.4.24.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Metalloendopeptidases"
RHEA:70154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-909738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 bind the common beta chain (Canis familiaris)
REACT:R-HSA-9700114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 (Homo sapiens)
REACT:R-GGA-8853529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBB yielding ubiquitin (Gallus gallus)
REACT:R-BTA-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Bos taurus)
RHEA:28499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + mycothiol => S-(hydroxymethyl)mycothiol
RHEA:25460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + sibirene
REACT:R-RNO-5362412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYVN1 ubiquitinates Hh C-terminal fragments (Rattus norvegicus)
REACT:R-GGA-5668984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 or PAK2 phosphorylates MYLK (Gallus gallus)
REACT:R-DRE-8849094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RASA1 (Danio rerio)
RHEA:43540	skos:prefLabel	"[isocitrate dehydrogenase (NADP(+))] kinase"
RHEA:43540	skos:altLabel	"isocitrate dehydrogenase kinase (phosphorylating)"
RHEA:43540	skos:altLabel	"isocitrate dehydrogenase kinase/phosphatase"
RHEA:43540	skos:altLabel	"isocitrate dehydrogenase kinase"
RHEA:43540	skos:altLabel	"ICDH kinase/phosphatase"
RHEA:43540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]
RHEA:43540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[isocitrate dehydrogenase (NADP(+))] kinase"
RHEA:43540	skos:altLabel	"IDH-K/P"
RHEA:43540	skos:altLabel	"IDHK/P"
RHEA:43540	skos:altLabel	"IDH kinase"
RHEA:43540	skos:altLabel	"IDH kinase/phosphatase"
REACT:R-DDI-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Dictyostelium discoideum)
REACT:R-SSC-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Sus scrofa)
REACT:R-HSA-8853444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PHLDA1 (Homo sapiens)
REACT:R-DME-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Drosophila melanogaster)
REACT:R-RNO-389652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Rattus norvegicus)
REACT:R-CFA-6809720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM1:MTMR12 (Canis familiaris)
REACT:R-DME-1295604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-RAF dissociates from S111/S120 p-SPRY2 (Drosophila melanogaster)
EC:1.14.12.19	skos:prefLabel	"3-phenylpropanoate dioxygenase"
EC:1.14.12.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-phenylpropanoate dioxygenase"
EC:1.14.12.19	skos:altLabel	"3-phenylpropionate dioxygenase"
EC:1.14.12.19	skos:altLabel	"HcaA1A2CD"
EC:1.14.12.19	skos:altLabel	"Hca dioxygenase"
REACT:R-HSA-167089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex (Homo sapiens)
RHEA:39622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH <=> (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)
REACT:R-BTA-5621353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Bos taurus)
RHEA:27551	skos:altLabel	"undecaprenyl pyrophosphate synthase"
RHEA:27551	skos:altLabel	"undecaprenyl pyrophosphate synthetase"
RHEA:27551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate
RHEA:27551	skos:prefLabel	"ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]"
RHEA:27551	skos:altLabel	"ditrans,polycis-undecaprenyl-diphosphate synthase"
RHEA:27551	skos:altLabel	"bactoprenyl-diphosphate synthase"
RHEA:27551	skos:altLabel	"UPP synthetase"
RHEA:27551	skos:altLabel	"undecaprenyl-diphosphate synthase"
RHEA:27551	skos:altLabel	"ditrans,polycis-undecaprenylcistransferase"
RHEA:27551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]"
RHEA:26423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + thyroxine => adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate
REACT:R-HSA-1183128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Homo sapiens)
REACT:R-HSA-201521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK autophosphorylation downstream of PTN and MDK (Homo sapiens)
RHEA:18333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + oleandomycin = ADP + H(+) + oleandomycin 2'-O-phosphate
RHEA:18333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"macrolide 2'-kinase"
RHEA:18333	skos:prefLabel	"macrolide 2'-kinase"
REACT:R-BTA-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Bos taurus)
REACT:R-SSC-8942208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOXE3 isomerises 12R-HpETE to HXA3 (Sus scrofa)
REACT:R-SSC-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Sus scrofa)
EC:7.3.2.-	skos:prefLabel	"Linked to the hydrolysis of a nucleoside triphosphate"
EC:7.3.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Linked to the hydrolysis of a nucleoside triphosphate"
REACT:R-HSA-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Homo sapiens)
RHEA:43085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(34) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
GO:0018590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylsilanetriol hydroxylase activity
GO:0048531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,3-galactosyltransferase activity
GO:0071618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysophosphatidylethanolamine acyltransferase activity
RHEA:57283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA
RHEA:61823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose <=> epiandrosterone 3-beta-D-glucoside + H(+) + UDP
REACT:R-CEL-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)
REACT:R-BTA-1855180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Bos taurus)
REACT:R-MMU-9021072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC7, ZDHHC21 palmitoylate ESR1 (Mus musculus)
RHEA:32185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-5-en-3-one + H2O2 => cholesterol + O2
REACT:R-CEL-163751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Caenorhabditis elegans)
REACT:R-SSC-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)
RHEA:59917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H2O + NADP(+) => (2E)-octenoate + 2 H(+) + NADPH
REACT:R-HSA-6785524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective C1GALT1C1 does not bind C1GALT1 (Homo sapiens)
REACT:R-GGA-5357757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)
RHEA:28037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dADP + H2O <=> [thioredoxin]-dithiol + ADP
REACT:R-BTA-5696415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-ETNPPL tetramer hydrolyses PETA (Bos taurus)
REACT:R-DME-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Drosophila melanogaster)
RHEA:21007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantolactone + A <=> 2-dehydropantolactone + AH2
REACT:R-BTA-3149494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC:cob(II)alamin binds MMADHC (Bos taurus)
REACT:R-MMU-5693055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)
REACT:R-GGA-5693346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CECRI deaminates Ade-Rib to Ino (Gallus gallus)
REACT:R-XTR-428752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:Gq complex (Xenopus tropicalis)
REACT:R-RNO-5693536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDC1 (Rattus norvegicus)
REACT:R-GGA-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Gallus gallus)
REACT:R-SSC-432237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Sus scrofa)
RHEA:68063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:38004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate => 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate
GO:0033709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ARD1p
GO:0033709	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-arabinitol:NADP+ dehydrogenase activity
GO:0033709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity
GO:0033709	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-arabinitol dehydrogenase 1 activity
GO:0033709	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	NADP+-dependent D-arabinitol dehydrogenase activity
REACT:R-HSA-8955285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
RHEA:39478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O
RHEA:26100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)
REACT:R-CEL-111289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)
RHEA:62983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenamide + H2O <=> (9Z)-hexadecenoate + NH4(+)
RHEA:45517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]
RHEA:40401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NADP(+) => 1,2-dihydro-beta-NADP + H(+) + O2
REACT:R-MMU-177934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR autophosphorylation (Mus musculus)
RHEA:44505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + an all-trans-polyprenyl diphosphate => a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate
REACT:R-MMU-2424476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV2/3 (Mus musculus)
RHEA:66138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyltyramine => acetyl-CoA + tyramine
RHEA:61748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rubusoside + UDP-alpha-D-glucose = H(+) + stevioside + UDP
RHEA:31053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+) => (3R)-beta-leucine + H2O + NAD(+)
REACT:R-DRE-9701524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated downstream of active ALK (Danio rerio)
RHEA:48824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + Lc4Cer = a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)
REACT:R-DRE-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Danio rerio)
RHEA:29992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-lyxopyranose(in) => H(+)(out) + L-lyxopyranose(out)
RHEA:53975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
RHEA:28861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ag(+)(out) + H(+)(out) => Ag(+)(in) + H(+)(in)
RHEA:27704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagaturonate => aldehydo-D-galacturonate
RHEA:47522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isolithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH
REACT:R-SSC-1013020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Sus scrofa)
REACT:R-GGA-4641350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TOP2A with SUMO2,3 (Gallus gallus)
RHEA:55358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol => 11-cis-retinol
REACT:R-MMU-159819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Mus musculus)
RHEA:19538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol 1-phosphate + H2O => D-mannitol + phosphate
REACT:R-MMU-964773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXGR1 binds 2OG (Mus musculus)
RHEA:49113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenazine-1-carboxylate + S-adenosyl-L-methionine => 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine
GO:0008998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonucleoside-triphosphate reductase (thioredoxin)"
GO:0008998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity
GO:0008998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate
GO:0008998	skos:altLabel	"ribonucleotide reductase"
GO:0008998	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribonucleotide reductase activity
GO:0008998	skos:prefLabel	"ribonucleoside-triphosphate reductase (thioredoxin)"
GO:0008998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleoside-triphosphate reductase activity
GO:0008998	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity
REACT:R-MMU-9627078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP9 (Mus musculus)
REACT:R-HSA-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Homo sapiens)
RHEA:44428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol
REACT:R-XTR-8953037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F8 forms homodimers (Xenopus tropicalis)
REACT:R-HSA-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Homo sapiens)
REACT:R-BTA-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Bos taurus)
RHEA:63538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bradykinin(1-7) + L-phenylalanine => bradykinin(1-8) + H2O
REACT:R-MMU-975594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLB1 hydrolyses RPALM to atROL (Mus musculus)
GO:0052731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3X11A
GO:0052731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphocholine phosphatase activity
GO:0052731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoethanolamine phosphohydrolase activity
GO:0052731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho is dephosphorylated to Cho by PHOSPHO1 (Homo sapiens)
GO:0052731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PHOSPHO1
RHEA:59082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose
REACT:R-HSA-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Homo sapiens)
REACT:R-HSA-9023163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) (Homo sapiens)
REACT:R-DRE-392195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gi activation by P2Y purinoceptor 12 (Danio rerio)
RHEA:13015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose
REACT:R-DRE-1614336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Danio rerio)
REACT:R-HSA-140700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Homo sapiens)
REACT:R-GGA-5654625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds SHC1 (Gallus gallus)
RHEA:37554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-D-glucose 6-phosphate + L-glutamate <=> 2-oxoglutarate + D-kanosamine 6-phosphate
RHEA:48943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-aminoacyl-L-amino acid + H2O <=> 2 an L-alpha-amino acid
REACT:R-SSC-349657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)
RHEA:39819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-RNO-9027281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Rattus norvegicus)
REACT:R-BTA-1449687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticosteroids bind to CBG in blood (Bos taurus)
REACT:R-DME-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Drosophila melanogaster)
RHEA:36156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + Co(II)-factor III + S-adenosyl-L-methionine => A + Co-precorrin-4 + S-adenosyl-L-homocysteine
GO:1901480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)
GO:1901480	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oleate transporter activity
GO:1901480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oleate transmembrane transporter activity
REACT:R-MMU-398185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG binds plexin B1 (Mus musculus)
RHEA:18725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin
REACT:R-HSA-168184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
RHEA:45948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]
REACT:R-SCE-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Saccharomyces cerevisiae)
RHEA:56763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-9634169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 and NDC1 bind the Nup93 complex (Mus musculus)
REACT:R-DRE-196350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Danio rerio)
REACT:R-XTR-2533950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP14, TMPRSS6 (Xenopus tropicalis)
RHEA:60833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-guanosine in mRNA + H2O => a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate
REACT:R-HSA-2065357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)
REACT:R-SSC-2028583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS2 (Sus scrofa)
RHEA:25036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + NADP(+) <=> all-trans-retinal + H(+) + NADPH
RHEA:33917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + methylamine + succinate semialdehyde => 4-(methylamino)butanoate + H2O + O2
RHEA:37991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocopherol + S-adenosyl-L-methionine = beta-tocopherol + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Caenorhabditis elegans)
EC:3.6.1.71	skos:prefLabel	"adenosine-5'-diphospho-5'-[DNA] diphosphatase"
EC:3.6.1.71	skos:altLabel	"aprataxin"
EC:3.6.1.71	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosine-5'-diphospho-5'-[DNA] diphosphatase"
EC:3.6.1.71	skos:altLabel	"5'-App5'-DNA adenylate hydrolase"
RHEA:67340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + quercetin 3-O-beta-D-glucoside = CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)
REACT:R-MMU-2454208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta and gamma subunits by LYN (Mus musculus)
REACT:R-BTA-976743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates plasma Factor H-bound C3b (Bos taurus)
REACT:R-DME-5433072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Drosophila melanogaster)
RHEA:31776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate
RHEA:14353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate 6-phosphate + H(+) = CO2 + L-xylulose 5-phosphate
RHEA:14353	skos:altLabel	"3-keto-L-gulonate 6-phosphate decarboxylase"
RHEA:14353	skos:altLabel	"3-dehydro-L-gulonate-6-phosphate carboxy-lyase"
RHEA:14353	skos:prefLabel	"3-dehydro-L-gulonate-6-phosphate decarboxylase"
RHEA:14353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydro-L-gulonate-6-phosphate decarboxylase"
RHEA:14353	skos:altLabel	"KGPDC"
REACT:R-MMU-1793209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses Chondroitin chains (Mus musculus)
REACT:R-SPO-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)
REACT:R-GGA-354165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
RHEA:60805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A19 + O2 => CO2 + gibberellin A17 + H(+) + succinate
REACT:R-SPO-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Schizosaccharomyces pombe)
REACT:R-SCE-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
RHEA:63086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + 2 H2O + ilicicolin A => chloride + FADH2 + ilicicolin B + O2
REACT:R-BTA-1433415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 (Bos taurus)
REACT:R-DRE-174447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation on the C-strand of the telomere (Danio rerio)
REACT:R-GGA-351412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of MRE11 and NBS1 leads to nuclear localization of MRN complex (Gallus gallus)
REACT:R-DRE-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Danio rerio)
REACT:R-SCE-203611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-myristoylation of eNOS (Saccharomyces cerevisiae)
RHEA:28329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + wogonin 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + wogonin
REACT:R-MMU-174119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Plk1 (Mus musculus)
RHEA:44603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP + H(+) <=> a fatty acyl-AMP + diphosphate
REACT:R-HSA-1912382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature NOTCH heterodimer traffics to the plasma membrane (Homo sapiens)
REACT:R-GGA-421517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of delta-aminolevulinate from the mitochondrial matrix to the cytosol (Gallus gallus)
REACT:R-GGA-5682802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI3 binds ADAM22,23,synatxin1 (Gallus gallus)
RHEA:38308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-SSC-9700200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRZ dephosphorylates ligand-bound ALK dimers (Sus scrofa)
REACT:R-DRE-6807053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)
REACT:R-HSA-8944218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VIII (Homo sapiens)
REACT:R-HSA-2514831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP14 (Homo sapiens)
REACT:R-DDI-947531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)
RHEA:13670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + CO2
REACT:R-CFA-211950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 24-hydroxylates CTL (Canis familiaris)
REACT:R-DRE-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Danio rerio)
REACT:R-MMU-380905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serotonin loaded synaptic vesicle docking and priming (Mus musculus)
RHEA:28757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + dihydroxyacetone phosphate => a ubiquinone + sn-glycerol 3-phosphate
REACT:R-HSA-8983299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)
REACT:R-SCE-176956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of GINS complex (Saccharomyces cerevisiae)
REACT:R-DRE-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Danio rerio)
REACT:R-MMU-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Mus musculus)
GO:0016595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamic acid binding
GO:0016595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate binding
RHEA:25113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyridoxine 5'-phosphate => phosphate + pyridoxine
REACT:R-HSA-5620975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PIPs (Homo sapiens)
REACT:R-CFA-5654167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds PLCG1 (Canis familiaris)
RHEA:67741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-neuraminate => aceneuramate
REACT:R-SSC-6809720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM1:MTMR12 (Sus scrofa)
RHEA:13586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoate => ADP + butanoyl phosphate
RHEA:13525	skos:prefLabel	"camphor 5-monooxygenase"
RHEA:13525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"camphor 5-monooxygenase"
RHEA:13525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]
RHEA:13525	skos:altLabel	"cytochrome p450-cam"
RHEA:13525	skos:altLabel	"camphor 5-exo-methylene hydroxylase"
REACT:R-XTR-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)
REACT:R-GGA-199093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXADR binds to AMICA1 (Gallus gallus)
RHEA:31348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-abscisic acid D-glucopyranosyl ester + H2O => 2-cis-(+)-abscisate + beta-D-glucose + H(+)
REACT:R-CFA-2046089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Canis familiaris)
RHEA:71761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + heptanedioate(out) => 2-oxoglutarate(out) + heptanedioate(in)
RHEA:42122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + H(+) + NADPH => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)
REACT:R-HSA-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Homo sapiens)
RHEA:47173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) => 5alpha-cholest-8-en-3-one + CO2 + NADH
REACT:R-SPO-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Schizosaccharomyces pombe)
REACT:R-BTA-2028598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS1 (Bos taurus)
RHEA:46526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-CEL-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-MMU-3296126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Mus musculus)
REACT:R-RNO-6783177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates GATA3,IL33 (Rattus norvegicus)
RHEA:15418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arogenate + NADP(+) => CO2 + L-tyrosine + NADPH
RHEA:15988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + NAD(+) <=> CO2 + NADH
REACT:R-HSA-450971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Homo sapiens)
RHEA:66210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8R)-8-hydroxynonenoyl-CoA + H2O2 => (8R)-8-hydroxynonanoyl-CoA + O2
GO:0062189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
GO:0062189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anandamide 14,15 epoxidase activity
RHEA:35079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	doxorubicin(in) = doxorubicin(out)
REACT:R-GGA-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Gallus gallus)
REACT:R-MMU-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Mus musculus)
RHEA:25594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + isochorismate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2
RHEA:71954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + sulfate(out) <=> 3 Na(+)(in) + sulfate(in)
REACT:R-XTR-5634729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Xenopus tropicalis)
REACT:R-HSA-2179402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MMP3 can cleave pro-HBEGF to form active HBEGF (Homo sapiens)
REACT:R-RNO-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Rattus norvegicus)
REACT:R-HSA-6805792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S291-PHF20 translocates to cytosol (Homo sapiens)
REACT:R-DDI-6788556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to NDUFV1, V2 (Dictyostelium discoideum)
RHEA:17845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH
RHEA:17845	skos:prefLabel	"5-amino-6-(5-phosphoribosylamino)uracil reductase"
RHEA:17845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-amino-6-(5-phosphoribosylamino)uracil reductase"
REACT:R-MMU-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
REACT:R-CFA-8942575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Canis familiaris)
GO:0052602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chloronitrobenzene nitroreductase activity
REACT:R-CEL-8848818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CBL (Caenorhabditis elegans)
RHEA:70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate
REACT:R-MMU-354124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pPTK2 by SRC (Mus musculus)
RHEA:56902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP => globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine
RHEA:34983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate(in) = sulfate(out)
REACT:R-BTA-202717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of CEACAMs (Bos taurus)
REACT:R-XTR-3965450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAAM1 recruits PFN1 (Xenopus tropicalis)
REACT:R-DDI-211983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2J2 oxidises ARA (Dictyostelium discoideum)
REACT:R-RNO-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Rattus norvegicus)
REACT:R-HSA-8869667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxLDL:CD36 binds TLR4:TLR6 (Homo sapiens)
REACT:R-DME-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Drosophila melanogaster)
REACT:R-SCE-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Saccharomyces cerevisiae)
RHEA:23759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinono-1,4-lactone + O2 <=> dehydro-D-arabinono-1,4-lactone + H(+) + H2O2
REACT:R-DRE-975122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Danio rerio)
REACT:R-CFA-5672978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF phosphorylates MAP2K dimer (Canis familiaris)
RHEA:53669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
REACT:R-DRE-193792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Danio rerio)
REACT:R-BTA-6799981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 binds bacterial peptidoglycan (Bos taurus)
REACT:R-GGA-112271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex dissociates (Gallus gallus)
RHEA:70983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)
RHEA:21352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)
RHEA:21352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase"
RHEA:21352	skos:altLabel	"steroid 4,5-dioxygenase"
RHEA:21352	skos:altLabel	"3-alkylcatechol 2,3-dioxygenase"
RHEA:21352	skos:prefLabel	"3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase"
GO:0033780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP3A4
GO:0033780	skos:altLabel	"taurochenodeoxycholate 6alpha-monooxygenase"
GO:0033780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taurochenodeoxycholate 6alpha-hydroxylase"
GO:0033780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurochenodeoxycholate 6alpha-monooxygenase activity
GO:0033780	skos:altLabel	"CYP4A21"
GO:0033780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CYP4A21
GO:0033780	skos:prefLabel	"taurochenodeoxycholate 6alpha-hydroxylase"
GO:0033780	skos:altLabel	"CYP3A4"
GO:0033780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurochenodeoxycholate 6alpha-hydroxylase activity
GO:0033780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity
GO:0016996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-alpha-(2,8)-sialidase activity
GO:0016996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"endo-alpha-sialidase"
GO:0016996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-N-acylneuraminidase activity
GO:0016996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity
GO:0016996	skos:altLabel	"poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase"
GO:0016996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-N-acetylneuraminidase activity
GO:0016996	skos:altLabel	"endo-N-acetylneuraminidase"
GO:0016996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity
GO:0016996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-2,8-sialosylhydrolase activity
GO:0016996	skos:prefLabel	"endo-alpha-sialidase"
GO:0016996	skos:altLabel	"endoneuraminidase"
GO:0016996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoneuraminidase activity
GO:0016996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polysialoside (2->8)-alpha-sialosylhydrolase activity
GO:0016996	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endosialidase activity
REACT:R-CFA-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Canis familiaris)
RHEA:32637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:29477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-cubenene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:45164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
REACT:R-PFA-70713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDH transfers CoA group from CoA-SH to BCAAs (Plasmodium falciparum)
RHEA:72102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + O-acetyl-(R)-carnitine(out) <=> Na(+)(in) + O-acetyl-(R)-carnitine(in)
REACT:R-PFA-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Plasmodium falciparum)
REACT:R-XTR-2428922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Xenopus tropicalis)
REACT:R-RNO-170978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-FRS2:CRKL binds C3G (Rattus norvegicus)
RHEA:34763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate(out) + succinate(in) = (S,S)-tartrate(in) + succinate(out)
REACT:R-SSC-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Sus scrofa)
REACT:R-HSA-9661432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds ALB (Homo sapiens)
REACT:R-BTA-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Bos taurus)
RHEA:57145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-HSA-9757448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST translocates from cytosol to extracellular region (Homo sapiens)
REACT:R-MMU-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Mus musculus)
GO:0102951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetyl-phenylalanine synthetase activity
RHEA:18863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine
GO:0000906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6,7-dimethyl-8-ribityllumazine synthase activity
GO:0000906	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lumazine synthase activity
REACT:R-MMU-5617037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Mus musculus)
REACT:R-DRE-193965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 18HCORST to ALDO (Danio rerio)
REACT:R-DRE-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Danio rerio)
REACT:R-XTR-8868071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin recruits PIK3C2A (Xenopus tropicalis)
REACT:R-XTR-2731074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Xenopus tropicalis)
REACT:R-SSC-4085133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUM (lumican) binds integrin alpha2beta1 (Sus scrofa)
REACT:R-RNO-5694433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 binds PREB (Rattus norvegicus)
RHEA:29806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-valine(out) <=> ADP + H(+) + L-valine(in) + phosphate
RHEA:32268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + glyoxylate => glycine + succinate semialdehyde
REACT:R-XTR-5696564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP25 deubiquitinates DDX58 (Xenopus tropicalis)
RHEA:15009	skos:altLabel	"tetrahydrofolate dehydrogenase"
RHEA:15009	skos:prefLabel	"dihydrofolate reductase"
RHEA:15009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH
RHEA:15009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrofolate reductase"
GO:0050452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:NADP+ oxidoreductase (CoA-acylating)
GO:0050452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-glutathione reductase (NADPH) activity
GO:0050452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH2:CoA-glutathione oxidoreductase activity
GO:0050452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme A disulfide-glutathione reductase activity
GO:0050452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent coenzyme A-SS-glutathione reductase activity
GO:0050452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-glutathione reductase activity
GO:0050452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:CoA-glutathione oxidoreductase activity
GO:0050452	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme A glutathione disulfide reductase activity
RHEA:44459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine
REACT:R-DRE-76500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBXAS1 isomerises PGH2 to TXA2 (Danio rerio)
REACT:R-XTR-392530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S400-Cot phosphorylates NIK (Xenopus tropicalis)
GO:0005432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium:sodium antiporter activity
GO:0005432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sodium:calcium exchange
GO:0005432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/calcium exchanger
GO:0005432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitochondrial sodium/calcium ion exchange
REACT:R-MMU-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Mus musculus)
REACT:R-GGA-6787632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMDS dehydrates GDP-Man to GDP-DHDMan (Gallus gallus)
RHEA:21080	skos:prefLabel	"methionine adenosyltransferase"
RHEA:21080	skos:altLabel	"S-adenosylmethionine synthetase"
RHEA:21080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine
RHEA:21080	skos:altLabel	"AdoMet synthetase"
RHEA:21080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionine adenosyltransferase"
REACT:R-HSA-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Homo sapiens)
RHEA:48012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-5-nitrocatechol + NADPH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite
RHEA:44158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + phosphate => 1D-myo-inositol 5-phosphate + H2O
REACT:R-DME-376123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM associates with Rac1-GTP:pPAK1 (Drosophila melanogaster)
RHEA:53430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine in DNA + S-methyl-L-cysteinyl-[protein] => a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein]
REACT:R-XTR-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Xenopus tropicalis)
REACT:R-HSA-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
REACT:R-BTA-201648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, Endofin, recruits R-Smad1/5/8 (Bos taurus)
RHEA:44646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O
REACT:R-HSA-9026901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1 (Homo sapiens)
EC:2.4.2.31	skos:altLabel	"mono(ADP-ribosyl)transferase"
EC:2.4.2.31	skos:altLabel	"ADP-ribosyltransferase"
EC:2.4.2.31	skos:altLabel	"NAD(P)(+)--arginine ADP-ribosyltransferase"
EC:2.4.2.31	skos:altLabel	"NAD(P)(+)--protein-arginine ADP-ribosyltransferase"
EC:2.4.2.31	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(+)--protein-arginine ADP-ribosyltransferase"
EC:2.4.2.31	skos:altLabel	"mono-ADP-ribosyltransferase"
EC:2.4.2.31	skos:prefLabel	"NAD(+)--protein-arginine ADP-ribosyltransferase"
RHEA:37020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-serine + H2O => 3-hydroxypyruvate + AH2 + NH4(+)
REACT:R-HSA-9701810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the STAT5A gene (Homo sapiens)
REACT:R-HSA-2559468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR1/2 ligand binds to CD14 (Homo sapiens)
GO:0018592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol 4-monooxygenase activity
RHEA:34648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + squalene => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine
RHEA:57543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NTP-ribonucleotide-RNA + H2O <=> a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)
RHEA:48627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 <=> (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate
REACT:R-CEL-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Caenorhabditis elegans)
REACT:R-BTA-1237042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from extracellular region to cytosol (Bos taurus)
GO:0008332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low voltage gated calcium channel activity
GO:0008332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low voltage-gated calcium channel activity
GO:0008332	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T-type calcium channel
GO:0008332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	low voltage-dependent calcium channel activity
REACT:R-SSC-977615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates MCP/CR1-bound C4b/C3b (Sus scrofa)
GO:0005250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Homo sapiens)
GO:0005250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A-type (transient outward) potassium channel activity
RHEA:66269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + nonanoyl-AMP => AMP + H(+) + nonanoyl-CoA
REACT:R-CFA-201631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 3 (Canis familiaris)
REACT:R-CFA-202489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of Bcl10 (Canis familiaris)
RHEA:58533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + H2O => akuammicine + formate + H(+)
REACT:R-CFA-2161620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by PTGDS (Canis familiaris)
REACT:R-CFA-203662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Canis familiaris)
GO:0031880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 3 somatostatin receptor binding
GO:0031880	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 3 somatostatin receptor ligand
REACT:R-DRE-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Danio rerio)
REACT:R-GGA-444498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin-releasing hormone receptor binds thyrotropin (Gallus gallus)
RHEA:39586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)
REACT:R-CEL-442273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV1 is a GEF for Rho/Rac family GTPases (Caenorhabditis elegans)
REACT:R-XTR-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Xenopus tropicalis)
REACT:R-HSA-1220612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)
REACT:R-SSC-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Sus scrofa)
REACT:R-CFA-140355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS1 (Canis familiaris)
RHEA:14345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine decarboxylase"
RHEA:14345	skos:altLabel	"L-tyrosine carboxy-lyase"
RHEA:14345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-tyrosine = CO2 + tyramine
RHEA:14345	skos:prefLabel	"tyrosine decarboxylase"
RHEA:72724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-xylose(in) + UMP(out) => UDP-alpha-D-xylose(out) + UMP(in)
REACT:R-SPO-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Schizosaccharomyces pombe)
RHEA:47236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-MMU-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Mus musculus)
RHEA:58474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2
REACT:R-GGA-2002466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of allysine by LOX (Gallus gallus)
RHEA:39121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2
REACT:R-HSA-400204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds RXRA (Homo sapiens)
RHEA:22450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + psi-UMP => ATP + pseudouridine
REACT:R-RNO-420173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR1,CRHR2-1 binds CRH,UCN (Rattus norvegicus)
RHEA:70347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH
REACT:R-DRE-200711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Danio rerio)
REACT:R-DDI-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Dictyostelium discoideum)
REACT:R-MMU-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Mus musculus)
REACT:R-CFA-2023971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
REACT:R-DRE-8864125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Danio rerio)
REACT:R-DDI-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Dictyostelium discoideum)
RHEA:70706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cycloserine(in) + H(+)(in) <=> D-cycloserine(out) + H(+)(out)
REACT:R-RNO-8865182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7A hydrolyses K11diUb (Rattus norvegicus)
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS 3-alpha-galactosyltransferase activity
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide galactosyltransferase activity
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipopolysaccharide 3-alpha-galactosyltransferase activity
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:polysaccharide galactosyltransferase activity
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipopolysaccharide 1,3-galactosyltransferase activity
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lipopolysaccharide-alpha-1,3-D-galactosyltransferase
GO:0008918	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity
REACT:R-HSA-9012671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 binds CISH, SOCS1 and SOCS2 gene (Homo sapiens)
REACT:R-SSC-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Sus scrofa)
REACT:R-DME-3857336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB homodimerization (Drosophila melanogaster)
REACT:R-DRE-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Danio rerio)
REACT:R-PFA-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Plasmodium falciparum)
RHEA:48566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + trans-zeatin => 9-ribosyl-trans-zeatin 5'-phosphate + H2O
REACT:R-RNO-9653514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17L2 deubiquitinates RCE1 (Rattus norvegicus)
RHEA:65527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16033	skos:prefLabel	"gibberellin-44 dioxygenase"
RHEA:16033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gibberellin-44 dioxygenase"
RHEA:16033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A44 + O2 = CO2 + gibberellin A19 + H2O + succinate
RHEA:16033	skos:altLabel	"Gibberellin A44 oxidase"
RHEA:31655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine
REACT:R-XTR-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Xenopus tropicalis)
REACT:R-CFA-5626220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 binds the mother centriole (Canis familiaris)
RHEA:51292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]
GO:0018450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myrtenol dehydrogenase activity
REACT:R-CEL-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Caenorhabditis elegans)
REACT:R-CFA-428917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G13 activation by TP receptor (Canis familiaris)
RHEA:62170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose
REACT:R-RNO-2213236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Rattus norvegicus)
REACT:R-RNO-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Rattus norvegicus)
RHEA:62101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
RHEA:44784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-10 + S-adenosyl-L-methionine = H(+) + menaquinol-10 + S-adenosyl-L-homocysteine
GO:0120319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain fatty acid omega-1 hydroxylase activity
GO:0120319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0120319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P450 fatty acid omega-1 hydroxylase activity
REACT:R-CEL-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Caenorhabditis elegans)
RHEA:39855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol
REACT:R-BTA-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Bos taurus)
REACT:R-XTR-6807229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)
EC:2.7.1.178	skos:altLabel	"2-keto-3-deoxy-D-gluconate kinase"
EC:2.7.1.178	skos:prefLabel	"2-dehydro-3-deoxyglucono/galactono-kinase"
EC:2.7.1.178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxyglucono/galactono-kinase"
EC:2.7.1.178	skos:altLabel	"KDG kinase"
RHEA:56116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-decaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)
RHEA:65778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CEL-5625416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anterograde IFT (Caenorhabditis elegans)
REACT:R-BTA-193460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Bos taurus)
RHEA:43465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-RNO-382052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130Cas and C3G bind PDGFR bound Crk (Rattus norvegicus)
RHEA:32097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+) => acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose
RHEA:16806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + deacetoxycephalosporin C + O2 => CO2 + deacetylcephalosporin C + succinate
REACT:R-BTA-5628905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Bos taurus)
REACT:R-BTA-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Bos taurus)
REACT:R-MMU-749454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gi complex dissociates (Mus musculus)
REACT:R-PFA-446185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of GlcNAc6P to GlcNAc1P (Plasmodium falciparum)
RHEA:58359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + L-arginyl-[protein] + succinate
RHEA:12712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)
RHEA:32781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Co(2+)(in) + H(+) + phosphate => ATP + Co(2+)(out) + H2O
REACT:R-DDI-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Dictyostelium discoideum)
RHEA:28989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + N-acetylneuraminate(out) => H(+)(in) + N-acetylneuraminate(in)
RHEA:37441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate
REACT:R-CFA-8875817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates STAT3 (Canis familiaris)
REACT:R-XTR-5244692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)
RHEA:53629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate
RHEA:35147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)
RHEA:29393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + GMP + H(+) => GTP + H2O
REACT:R-CFA-5676940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Canis familiaris)
REACT:R-XTR-381543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP4 binds IGF forming IGF:IGFBP4 (Xenopus tropicalis)
RHEA:58645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => (9Z,12Z,15Z)-octadecatrienamide + glyoxylate
REACT:R-MMU-4641206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPOs bind LGRs (Mus musculus)
REACT:R-SSC-2179415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Sus scrofa)
RHEA:24032	skos:altLabel	"isomaltulose synthetase"
RHEA:24032	skos:altLabel	"sucrose glucosylmutase"
RHEA:24032	skos:prefLabel	"isomaltulose synthase"
RHEA:24032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose = 6-O-alpha-D-glucopyranosyl-D-fructose
RHEA:24032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isomaltulose synthase"
RHEA:24032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose = trehalulose
RHEA:14494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] => ADP-D-ribose + L-arginyl-[dinitrogen reductase]
REACT:R-CEL-372480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Caenorhabditis elegans)
REACT:R-CFA-352108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Canis familiaris)
RHEA:55168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate
RHEA:37617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol
REACT:R-HSA-1497796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH2 binding can lead to eNOS uncoupling (Homo sapiens)
RHEA:31706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol
REACT:R-RNO-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Rattus norvegicus)
REACT:R-DRE-4827383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Danio rerio)
REACT:R-RNO-425822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Rattus norvegicus)
REACT:R-RNO-432688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Rattus norvegicus)
RHEA:47048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + shikimate = 3-dehydroshikimate + a quinol
REACT:R-BTA-8878050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 and EP300 (Bos taurus)
RHEA:16978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + coenzyme M + NADP(+) => 2-oxopropyl-coenzyme M + CO2 + NADPH
REACT:R-HSA-198824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Homo sapiens)
RHEA:52086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxy-octadecanoate + H(+) + octadecanoate => 13-octadecanoyloxy-octadecanoate + H2O
RHEA:62453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-glutamate => AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]
RHEA:60119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + methylphosphonate + O2 <=> CO2 + hydroxymethylphosphonate + succinate
RHEA:40049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O
REACT:R-HSA-192417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)
REACT:R-GGA-352354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Gallus gallus)
REACT:R-MMU-1564142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV degradation by MMP2,3,4,9,10,12 (Mus musculus)
GO:0047304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2-aminoethyl)phosphonate:pyruvate aminotransferase activity
GO:0047304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminoethylphosphonate aminotransferase activity
GO:0047304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2-aminoethyl)phosphonic acid aminotransferase activity
GO:0047304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2-aminoethyl)phosphonate transaminase activity
GO:0047304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminoethylphosphonate--pyruvate aminotransferase activity
GO:0047304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2-aminoethyl)phosphonate aminotransferase activity
GO:0047304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoethylphosphonate-pyruvate aminotransferase activity
GO:0047304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoethylphosphonate-pyruvate transaminase activity
GO:0047304	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2-aminoethyl)phosphonate--pyruvate aminotransferase activity
REACT:R-MMU-2559639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV sulfilimine cross-linking by peroxidasin (Mus musculus)
REACT:R-CFA-428749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-proten Gq (Canis familiaris)
RHEA:53867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH
RHEA:66081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate
REACT:R-XTR-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Xenopus tropicalis)
RHEA:45271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-hydroxyechinenone + AH2 + O2 <=> 4',4'-dihydroxyechinenone + A + H2O
REACT:R-RNO-879909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of STAT5a/b by JAK2 (Rattus norvegicus)
RHEA:44813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-11 + CO2 + diphosphate
RHEA:39120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2
RHEA:27363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloromethane + S-adenosyl-L-homocysteine => chloride + S-adenosyl-L-methionine
GO:0070281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxamine binding
REACT:R-HSA-8937113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
RHEA:47077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)
RHEA:51299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(R)-S-oxide-[protein]
RHEA:12253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-D-glucosyl)-trans-coniferol + H2O => (E)-coniferol + D-glucose
RHEA:41250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate
RHEA:63009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-octadecenamide + H2O => (6Z)-octadecenoate + NH4(+)
RHEA:22127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-O-acetylajmaline + H2O <=> acetate + ajmaline + H(+)
REACT:R-SSC-2022061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan sulfate can be further sulfated on position 2 of iduronate (Sus scrofa)
REACT:R-CFA-8854908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates RET:GDNF:GFRA dimer (Canis familiaris)
REACT:R-CFA-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Canis familiaris)
REACT:R-SSC-9605609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Sus scrofa)
RHEA:48262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GD1a + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1
RHEA:67307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 <=> H2O2 + myceliothermophin E
RHEA:61059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]
RHEA:16770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)
REACT:R-RNO-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Rattus norvegicus)
REACT:R-SSC-1679098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Sus scrofa)
RHEA:67879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine <=> 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-MMU-8856808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of AP-2 complex and clathrin (Mus musculus)
REACT:R-DME-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Drosophila melanogaster)
RHEA:45145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)acryloyl-CoA + 2 H2O => acetaldehyde + CO2 + CoA + methanethiol
REACT:R-DRE-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Danio rerio)
REACT:R-HSA-2972962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter (Homo sapiens)
RHEA:14091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-glutamate => 2-oxoglutarate + glycine
REACT:R-HSA-5205798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate arginine-4 of histone H4 (Homo sapiens)
REACT:R-DME-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Drosophila melanogaster)
REACT:R-DDI-5665854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds UCHL5 (Dictyostelium discoideum)
RHEA:44887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)
REACT:R-BTA-5696997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP24 deubiquitinates DDB2 (Bos taurus)
REACT:R-MMU-8875523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS3 (Mus musculus)
REACT:R-DME-3215251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53INP1 and HIPK2 bind TP53 (Drosophila melanogaster)
RHEA:48251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) <=> CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)
REACT:R-RNO-426522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nonendonucleolytic RISC binds exactly matching target RNAs (Rattus norvegicus)
REACT:R-DRE-5671702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP1G2 binds HGS and CHMP2A (Danio rerio)
REACT:R-XTR-9014420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the phagocytic vesicle membrane (Xenopus tropicalis)
REACT:R-RNO-9615348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR2 (Rattus norvegicus)
RHEA:54761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate
REACT:R-HSA-9629497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves thymine glycol from telomeric DNA (Homo sapiens)
RHEA:19686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + tyramine => CoA + H(+) + N-[(E)-feruloyl]tyramine
REACT:R-GGA-2424246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind lecticans (Gallus gallus)
REACT:R-SPO-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Schizosaccharomyces pombe)
GO:0015091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric iron transmembrane transporter activity
GO:0015439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type heme transporter activity
GO:0015439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled heme transmembrane transporter activity
GO:0015439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent heme transmembrane transporter activity
GO:0015439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled heme transporter activity
GO:0015439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	haem-transporting ATPase activity
GO:0015439	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protoheme IX ABC transporter activity
GO:0015439	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heme ABC transporter
GO:0015439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heme-transporting ATPase activity
REACT:R-XTR-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Xenopus tropicalis)
RHEA:39443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)
REACT:R-HSA-2533950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP14, TMPRSS6 (Homo sapiens)
RHEA:64296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH = (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)
RHEA:27300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + phthalate => 2-formylbenzoate + H2O + NAD(+)
RHEA:47182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH => (25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+)
REACT:R-HSA-70679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH4A1 oxidises L-GluSS to Glu (Homo sapiens)
RHEA:69452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)
RHEA:45960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:27370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoin + CoA + NAD(+) => acetaldehyde + acetyl-CoA + H(+) + NADH
REACT:R-XTR-1912357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH ubiquitinates DTX (Xenopus tropicalis)
REACT:R-SSC-909732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT2 (Sus scrofa)
GO:0047043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-hydroxy-cholanate dehydrogenase activity
GO:0047043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity
GO:0047043	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3alpha-hydroxycholanate dehydrogenase activity
GO:0047043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-alpha-hydroxycholanate dehydrogenase activity
RHEA:68389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5,6-dihydroxyindole-2-carboxylate + O2 => 2 H2O + 2 indole-5,6-quinone-2-carboxylate
REACT:R-CFA-4551451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)
REACT:R-DRE-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Danio rerio)
RHEA:27929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMP(in) <=> UMP(out)
REACT:R-DRE-166869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MEKK1 (Danio rerio)
GO:0047783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	corticosterone methyl oxidase activity
GO:0047783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone 18-monooxygenase activity
GO:0047783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone 18-hydroxylase activity
GO:0047783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)
REACT:R-XTR-9755507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Xenopus tropicalis)
RHEA:62212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] = gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:58079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(11Z-eicosenoyl)-glycerol + H2O <=> (11Z)-eicosenoate + glycerol + H(+)
RHEA:40404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-XTR-201717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK2-mediated phosphorylation of DVL (Xenopus tropicalis)
RHEA:68142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,5R)-hexanediol + 2 NADP(+) => 2,5-hexanedione + 2 H(+) + 2 NADPH
REACT:R-MMU-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Mus musculus)
REACT:R-XTR-166015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of LBP with LPS (Xenopus tropicalis)
REACT:R-XTR-8865182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7A hydrolyses K11diUb (Xenopus tropicalis)
RHEA:21093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxydihydrochelirubine + S-adenosyl-L-methionine => dihydromacarpine + H(+) + S-adenosyl-L-homocysteine
EC:3.1.3.2	skos:altLabel	"phosphomonoesterase"
EC:3.1.3.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acid phosphatase"
EC:3.1.3.2	skos:prefLabel	"acid phosphatase"
EC:3.1.3.2	skos:altLabel	"glycerophosphatase"
EC:3.1.3.2	skos:altLabel	"acid phosphomonoesterase"
REACT:R-HSA-201787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
REACT:R-CFA-8956684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH polyubiquitinates TP73 (Canis familiaris)
REACT:R-MMU-174551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of alternative pathway C5 convertase (Mus musculus)
REACT:R-XTR-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)
RHEA:48991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + O2 + rifampicin <=> 2'-N-hydroxyrifampicin + H2O + NAD(+)
REACT:R-HSA-6800490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates PIDD1 (Homo sapiens)
REACT:R-SSC-1297333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Acrosin Heavy and Light Chain (Sus scrofa)
GO:0017080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium channel regulator activity
RHEA:15253	skos:prefLabel	"cis-aconitate decarboxylase"
RHEA:15253	skos:altLabel	"cis-aconitic decarboxylase"
RHEA:15253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-aconitate decarboxylase"
RHEA:15253	skos:altLabel	"CAD"
RHEA:15253	skos:altLabel	"cis-aconitate carboxy-lyase"
RHEA:15253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-aconitate + H(+) = CO2 + itaconate
REACT:R-RNO-2168888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha1-Microglobulin binds heme (Rattus norvegicus)
GO:0047377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-diacetoxybutinylbithiophene:4-acetate esterase activity
GO:0047377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity
GO:0047377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diacetoxybutynylbithiophene acetate esterase activity
GO:0047377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity
REACT:R-SSC-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Sus scrofa)
RHEA:25611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-allopyranose => beta-D-allofuranose
REACT:R-MMU-159771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein C to protein C (Mus musculus)
REACT:R-BTA-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Bos taurus)
RHEA:33699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-DME-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Drosophila melanogaster)
RHEA:61352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + riboflavin(in) = ADP + H(+) + phosphate + riboflavin(out)
REACT:R-BTA-8851011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 polyubiquitinates PTEN (Bos taurus)
RHEA:15015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secologanin + tryptamine => 3alpha(S)-strictosidine + H2O
REACT:R-DRE-193961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Danio rerio)
REACT:R-CFA-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Canis familiaris)
RHEA:67022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine
REACT:R-MMU-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Mus musculus)
REACT:R-CFA-264997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidation of cysteine to cystine in Proinsulin (Canis familiaris)
REACT:R-HSA-2023451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c P252X mutants bind ligand with enhanced affinity (Homo sapiens)
RHEA:47647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine
REACT:R-GGA-8850797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK13 (Gallus gallus)
RHEA:23858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hg(2+) + NADPH => H(+) + Hg + NADP(+)
REACT:R-SSC-2046175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Further sulfation on galactose residues produces KSPG (Sus scrofa)
RHEA:41880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+)
RHEA:61822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose
REACT:R-BTA-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Bos taurus)
REACT:R-BTA-5696080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B1 oxidises HXAL to PALM (Bos taurus)
REACT:R-MMU-6792871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNG1 recruits PP2A-PPP2R5C to MDM2 (Mus musculus)
RHEA:42435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-cis,cis-muconate <=> maleylacetate
RHEA:44752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
RHEA:20291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + H(+) => acetyl-CoA + H2O
RHEA:41453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-1-naphthoate + H(+) + NADPH + O2 => 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)
REACT:R-XTR-751039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (12/13) reassociates with G beta:gamma (Xenopus tropicalis)
REACT:R-GGA-4085033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Gallus gallus)
REACT:R-XTR-265153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Xenopus tropicalis)
RHEA:67856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)
RHEA:58974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + vanillate => H2O + O2 + vanillin
GO:0010487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thermospermine synthase activity
GO:0102428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol-3-O-glucoside 1,6-glucosyltransferase activity
REACT:R-CFA-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Canis familiaris)
REACT:R-BTA-400204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds RXRA (Bos taurus)
REACT:R-DDI-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Dictyostelium discoideum)
RHEA:62211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:70152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Mus musculus)
RHEA:69539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-tagatopyranose 1-phosphate + ATP <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)
REACT:R-DME-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Drosophila melanogaster)
REACT:R-HSA-139899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of BAD protein by 14-3-3 (Homo sapiens)
REACT:R-BTA-688985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63 polyubiquitinated RIP2 associates with the TAK1 complex (Bos taurus)
GO:0034836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-2-mercaptobenzothiazole monooxygenase activity
REACT:R-MMU-5696465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP45 deubiquitinates ERCC1 (Mus musculus)
RHEA:23819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + putrescine <=> 4-aminobutanal + L-glutamate
REACT:R-RNO-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Rattus norvegicus)
REACT:R-RNO-5693540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN activates ATM (Rattus norvegicus)
REACT:R-HSA-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Homo sapiens)
GO:0102695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity
REACT:R-RNO-8981606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin binds oxygen (Rattus norvegicus)
REACT:R-CFA-201810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ligand trap binds the ligand BMP2, blocking BMP signalling (Canis familiaris)
REACT:R-MMU-374248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR3 binds ligands CXCL9 to 11 (Mus musculus)
REACT:R-XTR-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Xenopus tropicalis)
REACT:R-CFA-9632906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ recruits RAS in response to estrogen stimulation (Canis familiaris)
REACT:R-MMU-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Mus musculus)
REACT:R-PFA-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)
REACT:R-CEL-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Caenorhabditis elegans)
REACT:R-HSA-5684071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF4 ubiquitinates MDC1 (Homo sapiens)
REACT:R-DME-429683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Drosophila melanogaster)
REACT:R-SSC-5692755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates MAPK6 (Sus scrofa)
RHEA:57900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate
RHEA:28185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate <=> (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate
REACT:R-MMU-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Mus musculus)
REACT:R-XTR-215526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F3 20-hydroxylates LTB4 (Xenopus tropicalis)
RHEA:64118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine
REACT:R-MMU-5686074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Mus musculus)
RHEA:57403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-acetylpapaveroxine + H2O <=> acetate + H(+) + narcotine hemiacetal
RHEA:35723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA
RHEA:71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-leucine(out) + H(+)(out) => glycyl-L-leucine(in) + H(+)(in)
REACT:R-SPO-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Schizosaccharomyces pombe)
REACT:R-SSC-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Sus scrofa)
REACT:R-CFA-9018907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Canis familiaris)
GO:1990310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type-III dockerin domain binding
REACT:R-XTR-1222491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoferrin scavenges iron ions (Xenopus tropicalis)
GO:0004772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol O-acyltransferase activity
GO:0004772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol-ester synthetase activity
GO:0004772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol-ester synthase activity
GO:1903877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-deoxycortisol binding
REACT:R-BTA-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Bos taurus)
REACT:R-RNO-1482546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)
RHEA:18375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP
REACT:R-SPO-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Schizosaccharomyces pombe)
REACT:R-CFA-376364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp8 associated secretory vesicle to plasma membrane transport (Canis familiaris)
RHEA:25738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:46789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0004335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactokinase activity
GO:0004335	skos:prefLabel	"galactokinase"
GO:0004335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactokinase"
GO:0004335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactokinase (phosphorylating)
GO:0004335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-galactose 1-phosphotransferase activity
GO:0004335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-galactose-1-phosphotransferase activity
GO:0004335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)
RHEA:43424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-HSA-9625510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter (Homo sapiens)
REACT:R-HSA-1482543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Homo sapiens)
REACT:R-MMU-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Mus musculus)
REACT:R-DME-432652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear CRY is degraded by the 26S proteasome (Drosophila melanogaster)
REACT:R-HSA-5607747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MALT1 oligomers (Homo sapiens)
RHEA:32785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycine betaine(in) + H(+) + phosphate => ATP + glycine betaine(out) + H2O
REACT:R-SPO-2730896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK4 by MEKK1 (Schizosaccharomyces pombe)
REACT:R-DRE-5218814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 autophorylates (Danio rerio)
GO:0140893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neutral amino acid, sodium:proton antiporter activity
GO:0140893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid-coupled Na+/H+ exchanger activity
RHEA:38955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine 1-phosphate(in) = an N-acylsphing-4-enine 1-phosphate(out)
REACT:R-HSA-141691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)
RHEA:16245	skos:prefLabel	"1-alkenylglycerophosphoethanolamine O-acyltransferase"
RHEA:16245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-alkenylglycerophosphoethanolamine O-acyltransferase"
RHEA:16245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:18242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysine => (2R,5S)-2,5-diaminohexanoate
REACT:R-SSC-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Sus scrofa)
REACT:R-SSC-376123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM associates with Rac1-GTP:pPAK1 (Sus scrofa)
REACT:R-BTA-5684836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC1B dimer binds PDPN (Bos taurus)
REACT:R-DDI-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Dictyostelium discoideum)
REACT:R-MMU-8964333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Mus musculus)
REACT:R-HSA-2470483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)
RHEA:62868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 = H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)
RHEA:54608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]
RHEA:24045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + O2 => 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)
REACT:R-BTA-2022911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSPG is secreted (Bos taurus)
RHEA:30495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]
RHEA:62161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate => N-(9Z-octadecenoyl) ethanolamine + phosphate
REACT:R-HSA-5607058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C:PROCR binds F2R (Homo sapiens)
REACT:R-BTA-140847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Bos taurus)
RHEA:12465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + UDP-alpha-D-galactose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP
RHEA:56987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate
REACT:R-HSA-1247841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
REACT:R-DME-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Drosophila melanogaster)
REACT:R-SSC-9604487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7:p-IRF7 translocates to the nucleus (Sus scrofa)
REACT:R-CEL-9750001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Caenorhabditis elegans)
REACT:R-HSA-9693243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the Golgi membrane (Homo sapiens)
RHEA:56393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)
RHEA:24567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo acid + succinyl-CoA <=> a 3-oxoacyl-CoA + succinate
RHEA:50294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-HSA-5205861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)
REACT:R-HSA-2428930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Homo sapiens)
REACT:R-DRE-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)
REACT:R-HSA-9013693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 binds RBPJ and MAML in the nucleus (Homo sapiens)
REACT:R-DRE-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Danio rerio)
GO:0047925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranoyl-CoA:carbon-dioxide ligase (ADP-forming)
GO:0047925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranoyl coenzyme A carboxylase activity
GO:0047925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-CoA carboxylase activity
GO:0047925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranoyl-CoA carboxylase activity
REACT:R-HSA-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Homo sapiens)
REACT:R-XTR-170847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Xenopus tropicalis)
RHEA:72802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-homoarginine(in) <=> L-arginine(in) + L-homoarginine(out)
REACT:R-GGA-5685319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex formation (Gallus gallus)
RHEA:11382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate => 2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2
REACT:R-DRE-83723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Danio rerio)
RHEA:63423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethylphosphonate + CTP <=> cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate
RHEA:65859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 1-hydroxy-3-oxo steroid <=> a steroid 1,3-dione + AH2
REACT:R-BTA-8950731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:IL27 translocates to the extracellular region (Bos taurus)
RHEA:55790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hydroxyacetone + NAD(+) => acetone + H(+) + NADH + O2
REACT:R-CFA-2426471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Canis familiaris)
RHEA:56740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + UDP-alpha-D-galactose = GalGb3Cer + H(+) + UDP
REACT:R-RNO-8940134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 binds FOLA (Rattus norvegicus)
RHEA:40358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-XTR-947673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanin-concentrating hormone receptors bind MCH (Xenopus tropicalis)
RHEA:18956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-erythro-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin
RHEA:34071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase"
RHEA:34071	skos:altLabel	"GlcNAc-1-phosphate transferase"
RHEA:34071	skos:altLabel	"UDP-GlcNAc:undecaprenyl phosphate GlcNAc-1-phosphate transferase"
RHEA:34071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP
RHEA:34071	skos:prefLabel	"UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase"
REACT:R-RNO-976743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates plasma Factor H-bound C3b (Rattus norvegicus)
GO:0047668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-amygdalin beta-glucosidase activity
GO:0047668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amygdalin beta-glucosidase"
GO:0047668	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amygdalin hydrolase activity
GO:0047668	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amygdalin beta-D-glucohydrolase activity
GO:0047668	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amygdalin glucosidase activity
GO:0047668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amygdalin beta-glucosidase activity
GO:0047668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amygdalin b-glucosidase activity
GO:0047668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-amygdalin + H2O = (R)-prunasin + D-glucose
GO:0047668	skos:prefLabel	"amygdalin beta-glucosidase"
GO:0047668	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	amygdalinase
REACT:R-MMU-9728664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1R agonists (Mus musculus)
RHEA:45704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + H(+) + NADPH
REACT:R-MMU-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Mus musculus)
REACT:R-HSA-2022412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)
REACT:R-SSC-391157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds SKAP2 (Sus scrofa)
REACT:R-RNO-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Rattus norvegicus)
RHEA:37219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-valine + H2O = 3-methyl-2-oxobutanoate + AH2 + NH4(+)
REACT:R-DRE-5633460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds TP53 (Danio rerio)
REACT:R-RNO-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Rattus norvegicus)
REACT:R-DME-4608852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 ubiquitinates PRICKLE1 (Drosophila melanogaster)
RHEA:36138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenal + H2O + NAD(+) <=> (E)-hexadec-2-enoate + 2 H(+) + NADH
RHEA:49032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:49032	skos:prefLabel	"(-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase"
RHEA:49032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase"
RHEA:49032	skos:altLabel	"CYP82D61"
RHEA:70810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-sulfo-D-erythrose <=> 4-deoxy-4-sulfo-D-erythrulose
RHEA:53184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-DRE-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Danio rerio)
RHEA:17851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + H2O => (3R)-3-hydroxybutanoyl-CoA
RHEA:55585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in mRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-6781867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Sus scrofa)
RHEA:54707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-XTR-174157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cyclin B (Xenopus tropicalis)
REACT:R-DRE-1676152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4KB binds to ARF1/3:GTP at the Golgi membrane (Danio rerio)
REACT:R-DDI-193362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-HSA-174124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phospho-Cdh1 (Homo sapiens)
EC:3.2.1.100	skos:altLabel	"exo-1,4-beta-mannobiohydrolase"
EC:3.2.1.100	skos:altLabel	"mannan 1,4-beta-mannobiosidase"
EC:3.2.1.100	skos:prefLabel	"mannan 1,4-mannobiosidase"
EC:3.2.1.100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannan 1,4-mannobiosidase"
GO:0033898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Bacillus subtilis ribonuclease"
GO:0033898	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribonucleate nucleotido-2'-transferase (cyclizing) activity
GO:0033898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bacillus subtilis ribonuclease activity
GO:0033898	skos:prefLabel	"Bacillus subtilis ribonuclease"
GO:0033898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proteus mirabilis RNase activity
GO:0033898	skos:altLabel	"bacterial RNA lyase"
REACT:R-CFA-2214351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates GORASP1 (Canis familiaris)
REACT:R-DME-5654425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds SHC1 (Drosophila melanogaster)
GO:0015101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organic cation transmembrane transporter activity
EC:2.4.99.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactosylceramide alpha-2,3-sialyltransferase"
EC:2.4.99.9	skos:altLabel	"ganglioside GM3 synthase"
EC:2.4.99.9	skos:prefLabel	"lactosylceramide alpha-2,3-sialyltransferase"
REACT:R-RNO-391933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP3 receptor can bind PGE2 (Rattus norvegicus)
REACT:R-BTA-9026780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Bos taurus)
REACT:R-DRE-9018894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Danio rerio)
REACT:R-BTA-1433418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Bos taurus)
RHEA:30864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-L-tyrosine + H2O => L-tyrosine + phosphate
GO:0008486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphoinositol-polyphosphate diphosphatase activity
GO:0008486	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DIPP activity
GO:0008486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphoinositol polyphosphate phosphohydrolase activity
GO:0008486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphospho-myo-inositol-polyphosphate diphosphohydrolase activity
GO:0008486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphoinositol-polyphosphate phosphohydrolase activity
REACT:R-BTA-174439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)
REACT:R-XTR-5577237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNH2:KCNE transport K+ from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-MMU-9706364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of ubiquitinated FLT3 (Mus musculus)
RHEA:61081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-minovincinine + acetyl-CoA => (+)-echitovenine + CoA
REACT:R-HSA-6802912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
REACT:R-MMU-70555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Mus musculus)
RHEA:38167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate
REACT:R-HSA-6782138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC5 and RPA bind TC-NER site (Homo sapiens)
REACT:R-MMU-6806629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tonofilament bundles (Mus musculus)
RHEA:39371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)
GO:0050598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)
GO:0050598	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taxane 13alpha-hydroxylase activity
GO:0050598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxane 13-alpha-hydroxylase activity
GO:0050598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxane 13a-hydroxylase activity
GO:0023024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class I protein complex binding
REACT:R-HSA-5244402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
RHEA:66833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + preasperterpenoid A
RHEA:66109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-cysteine => (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate
RHEA:61205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal => H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]
REACT:R-GGA-8863718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGFG1 binds VAMP7 (Gallus gallus)
RHEA:47394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic alcohol + H(+) + hexadecanoate => H2O + hexadecanoate ester
RHEA:64807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + S-(2-aminoethyl)-L-cysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine
REACT:R-PFA-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Plasmodium falciparum)
RHEA:28465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal(in) <=> pyridoxal(out)
REACT:R-RNO-71541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Rattus norvegicus)
REACT:R-SSC-9693125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF binds effectors at the plasma membrane (Sus scrofa)
REACT:R-SSC-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Sus scrofa)
RHEA:60915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine
RHEA:25739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-2530565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iC3b proteolysis (Gallus gallus)
RHEA:67449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal
RHEA:39992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine
REACT:R-RNO-430135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds ADAP (Rattus norvegicus)
RHEA:17050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-9 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-9
REACT:R-MMU-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Mus musculus)
REACT:R-HSA-9709406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to Cytochrome c oxidase (Homo sapiens)
RHEA:38775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
RHEA:67865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)
REACT:R-SSC-70773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Sus scrofa)
REACT:R-SCE-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Saccharomyces cerevisiae)
RHEA:42364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 2-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
RHEA:15138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol 1-phosphate + NAD(+) => H(+) + keto-L-tagatose 6-phosphate + NADH
REACT:R-MMU-1549564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPTN11 dephosphorylates SPRY2 (Mus musculus)
RHEA:72026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate(in) + urate(out) <=> nicotinate(out) + urate(in)
REACT:R-SCE-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Saccharomyces cerevisiae)
REACT:R-HSA-9603554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK3(496-641):NELFB translocates to mitochondrion (Homo sapiens)
RHEA:24598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(alpha)-acetyl-L-histidine => acetyl-CoA + L-histidine
RHEA:65499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH <=> 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)
REACT:R-DRE-210304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with PECAM1 (Danio rerio)
REACT:R-SSC-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Sus scrofa)
RHEA:13758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-desulfoglucotropeolin + UDP
REACT:R-MMU-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Mus musculus)
REACT:R-DME-110440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of DINR (Drosophila melanogaster)
REACT:R-SCE-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Saccharomyces cerevisiae)
RHEA:63491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-phenanthroquinone + H(+) + NADPH <=> NADP(+) + phenanthrene-9,10-diol
REACT:R-CFA-9606894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DAPP1 (p-BAM32) binds PLCG2 (Canis familiaris)
GO:0102324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity
REACT:R-BTA-8853755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Bos taurus)
RHEA:33904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pseudooxynicotine => 4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine
RHEA:43300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP
REACT:R-HSA-5205672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)
RHEA:53032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-RNO-200424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Rattus norvegicus)
REACT:R-BTA-981814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC2 transfers sialic acid to Core 1 mucins (Bos taurus)
REACT:R-XTR-174448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex on the C-strand of the telomere (Xenopus tropicalis)
RHEA:35145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA => benzoyl-CoA + 2 H(+) + 3 malonyl-CoA
RHEA:37427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
RHEA:53004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-BTA-68610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(2-5) complex (Bos taurus)
REACT:R-GGA-3296244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUCNR1 binds SUCCA (Gallus gallus)
REACT:R-XTR-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Xenopus tropicalis)
RHEA:42905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(748) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-CFA-3788061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by ADAM8 (Canis familiaris)
GO:0106373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyglucosone dehydrogenase activity
GO:0106373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH
RHEA:47474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-tetradecenoyl-CoA + NADP(+) => (2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH
RHEA:20756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + D-threo-isocitrate = 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA
RHEA:20756	skos:prefLabel	"isocitrate O-dihydroxycinnamoyltransferase"
RHEA:20756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isocitrate O-dihydroxycinnamoyltransferase"
RHEA:32350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + tricetin <=> 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-MMU-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Mus musculus)
REACT:R-MMU-190268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1c binds to Klotho-bound FGF23 (Mus musculus)
REACT:R-HSA-9685542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral release (Homo sapiens)
REACT:R-MMU-1472121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of p-KIT on Y900 by Src kinases (Mus musculus)
RHEA:46664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + H(+) + NADPH = 5beta-dihydrocorticosterone + NADP(+)
REACT:R-PFA-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Plasmodium falciparum)
REACT:R-DRE-2059926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPHP4 protein binds LATS proteins (Danio rerio)
RHEA:69027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-hydroxy-L-aspartate + NADPH + O2 <=> H2O + N,N-dihydroxy-L-aspartate + NADP(+)
REACT:R-CEL-6786652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIT1 hydrolyses CHIT to 3xADGP (Caenorhabditis elegans)
RHEA:19180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine <=> (3S)-3,6-diaminohexanoate
REACT:R-CFA-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Canis familiaris)
REACT:R-GGA-8951486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C4b (Gallus gallus)
REACT:R-CFA-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Canis familiaris)
REACT:R-BTA-444620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide S receptor binds neuropeptide S (Bos taurus)
REACT:R-SSC-176588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + PAPS => lithocholate sulfate + PAP (Sus scrofa)
REACT:R-CFA-6804276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TTC5 (Canis familiaris)
REACT:R-RNO-1296037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with large conductance (Rattus norvegicus)
REACT:R-BTA-9647999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCE1 cleaves S-Farn proRAS proteins (Bos taurus)
REACT:R-HSA-4615839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO2,3 (Homo sapiens)
RHEA:69684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein 7-O-beta-D-glucoside + H2O => beta-D-glucose + daidzein + H(+)
RHEA:23101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dAMP => ADP + dADP
REACT:R-MMU-5671707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Mus musculus)
RHEA:72264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + oxalate(in) => chloride(in) + oxalate(out)
REACT:R-CEL-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Caenorhabditis elegans)
RHEA:30494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]
RHEA:31270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexanoate + NADP(+) <=> 6-oxohexanoate + H(+) + NADPH
REACT:R-DRE-196417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of desmosterol to cholesterol (Danio rerio)
RHEA:69090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate + 2 H(+) + NADH => butanal + H2O + NAD(+)
REACT:R-DRE-74885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCYs converts GTP to cGMP (Danio rerio)
REACT:R-BTA-374919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline clearance from the synaptic cleft (Bos taurus)
RHEA:28653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-riburonosylhypoxanthine + H(+) + H2O => inosine + O2
REACT:R-SCE-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Saccharomyces cerevisiae)
REACT:R-SCE-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Saccharomyces cerevisiae)
REACT:R-HSA-159796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor IX to factor IX (Homo sapiens)
REACT:R-SSC-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Sus scrofa)
REACT:R-CFA-196086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Canis familiaris)
RHEA:61938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + cycloheximide(out) + H(+) + phosphate => ATP + cycloheximide(in) + H2O
REACT:R-SCE-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Saccharomyces cerevisiae)
REACT:R-RNO-375340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 62 mediated neuronal gap junction communication (Rattus norvegicus)
REACT:R-CFA-5649723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Canis familiaris)
REACT:R-BTA-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Bos taurus)
RHEA:54485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine
REACT:R-SPO-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Schizosaccharomyces pombe)
REACT:R-SSC-352191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A8-mediated uptake of neutral amino acids (Sus scrofa)
RHEA:54864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + sulcatone = 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)
REACT:R-HSA-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Homo sapiens)
REACT:R-RNO-4615889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC1 with SUMO1 (Rattus norvegicus)
REACT:R-RNO-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Rattus norvegicus)
RHEA:66232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IC-asc-C7-CoA + O2 = H2O2 + IC-asc-DeltaC7-CoA
RHEA:31060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + imidazole-4-acetaldehyde + NAD(+) => 2 H(+) + imidazole-4-acetate + NADH
REACT:R-HSA-9645692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1QBP promotes translocation of p14ARF to the mitochondrial matrix (Homo sapiens)
REACT:R-CFA-5423664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)
REACT:R-HSA-8862380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B13 binds lipid droplets (Homo sapiens)
GO:0004485	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylcrotonyl-CoA carboxylase activity
GO:0004485	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-methylcrotonyl-CoA carboxylase activity
GO:0004485	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylcrotonyl coenzyme A carboxylase activity
GO:0004485	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-methylcrotonyl CoA carboxylase activity
GO:0004485	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)
GO:0004485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Homo sapiens)
GO:0004485	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-methylcrotonyl coenzyme A carboxylase activity
GO:0004485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCCC activity
GO:0004485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylcrotonoyl-CoA carboxylase activity
REACT:R-CEL-8939204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR1:chaperone complex (Caenorhabditis elegans)
RHEA:47217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-8937844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC,YES1 phosphorylate YAP1 (Homo sapiens)
REACT:R-DRE-193060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
REACT:R-MMU-194017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 oxidises 11DCORST to CORST (Mus musculus)
REACT:R-GGA-8865182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7A hydrolyses K11diUb (Gallus gallus)
REACT:R-RNO-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Rattus norvegicus)
GO:0061714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folic acid receptor activity
GO:0061714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate receptor activity
RHEA:50776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH
REACT:R-RNO-139893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Granzyme-B activates BID by cleavage (Rattus norvegicus)
RHEA:39174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyeicosanoyl-CoA + NADP(+)
REACT:R-RNO-187545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cks1 with SCF(Skp2) complex (Rattus norvegicus)
REACT:R-XTR-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Xenopus tropicalis)
REACT:R-BTA-6794347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 dimerizes (Bos taurus)
REACT:R-HSA-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Homo sapiens)
REACT:R-DDI-1855159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)
REACT:R-HSA-9621406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2 and SREBF2 dimer bind CYP51A1 gene (Homo sapiens)
REACT:R-DRE-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Danio rerio)
REACT:R-HSA-1980056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAG1 binds NOTCH2 (Homo sapiens)
RHEA:44927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + acetyl-CoA + H2O <=> (R)-dihomocitrate + CoA + H(+)
REACT:R-GGA-373141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate <=> fumarate + H2O (Gallus gallus)
REACT:R-MMU-2161959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Mus musculus)
RHEA:49256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-N(pi)-phosphohistidine--D-glucosaminate phosphotransferase"
RHEA:49256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] = 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]
RHEA:49256	skos:altLabel	"2-amino-2-deoxy-D-gluconate PTS permease"
RHEA:49256	skos:prefLabel	"protein-N(pi)-phosphohistidine--D-glucosaminate phosphotransferase"
GO:0034881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrazinate hydrolase activity
REACT:R-DDI-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Dictyostelium discoideum)
RHEA:16101	skos:prefLabel	"chondroitin 4-sulfotransferase"
RHEA:16101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)
RHEA:16101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chondroitin 4-sulfotransferase"
REACT:R-RNO-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Rattus norvegicus)
REACT:R-RNO-9753944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Rattus norvegicus)
RHEA:57222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + methylglyoxal
REACT:R-CEL-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)
REACT:R-HSA-9610867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCMV Binds Host Cell Receptor - Endocytic Pathway (Homo sapiens)
REACT:R-HSA-3296309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR3 binds HCAR3 ligands (Homo sapiens)
RHEA:39481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH
RHEA:40424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-434989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA7A binds to PLXNC1 (Canis familiaris)
RHEA:40622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tridodecanoylglycerol <=> 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)
REACT:R-BTA-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Bos taurus)
RHEA:64952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCDP + H2O = dCMP + H(+) + phosphate
RHEA:64033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)
RHEA:28999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + homoserine lactone(in) = H(+)(in) + homoserine lactone(out)
REACT:R-DME-5632738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDIT4 binds 14-3-3 dimer (Drosophila melanogaster)
REACT:R-CFA-2162227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses (HA)2 (Canis familiaris)
RHEA:43189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2634) in 25S rRNA => H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine
REACT:R-RNO-210430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of L-Glutamate at the synapse (Rattus norvegicus)
RHEA:50730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetonitrile + H2O => (Z)-(4-hydroxyphenyl)acetaldehyde oxime
GO:0102946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol E UDP-glucosyltransferase activity
REACT:R-DDI-376851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Dictyostelium discoideum)
GO:0033916	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AgaA
GO:0033916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-agarase activity
GO:0033916	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	agarose 4-glycanohydrolase activity
GO:0033916	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	agarase activity
GO:0033916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-agarase"
GO:0033916	skos:altLabel	"agarase"
GO:0033916	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AgaB
GO:0033916	skos:altLabel	"endo-beta-agarase"
GO:0033916	skos:prefLabel	"beta-agarase"
GO:0033916	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	agarose 3-glycanohydrolase activity
REACT:R-HSA-9614790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2, SOX10 and SMARCA4 bind the MPZ gene (Homo sapiens)
RHEA:14305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
RHEA:14305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"proline--tRNA ligase"
RHEA:14305	skos:altLabel	"proline translase"
RHEA:14305	skos:altLabel	"prolyl-tRNA synthetase"
RHEA:14305	skos:prefLabel	"proline--tRNA ligase"
RHEA:15692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-2,4-diaminobutanoate <=> CO2 + propane-1,3-diamine
REACT:R-HSA-5228840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG (Homo sapiens)
RHEA:45863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA
REACT:R-XTR-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)
REACT:R-DME-9032751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Drosophila melanogaster)
RHEA:62436	skos:prefLabel	"L-lyxonate dehydratase"
RHEA:62436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-lyxonate dehydratase"
RHEA:62436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lyxonate = 2-dehydro-3-deoxy-L-arabinonate + H2O
REACT:R-RNO-198599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MDM2 (Rattus norvegicus)
RHEA:42223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
REACT:R-GGA-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Gallus gallus)
REACT:R-DRE-606287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSF complex binds the centromere (Danio rerio)
REACT:R-SSC-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Sus scrofa)
RHEA:30666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> hapalindole H
GO:1905576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b binding
REACT:R-SSC-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Sus scrofa)
RHEA:56189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
REACT:R-MMU-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Mus musculus)
REACT:R-DME-392751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 linked to actin cytoskeleton by ankyrin (Drosophila melanogaster)
REACT:R-MMU-2028555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Mus musculus)
GO:0102348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-docosan-2-enoyl-CoA reductase activity
REACT:R-CEL-428123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Caenorhabditis elegans)
RHEA:51994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-6798373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates DYRK2 (Xenopus tropicalis)
EC:3.1.22.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyribonuclease X"
EC:3.1.22.5	skos:prefLabel	"deoxyribonuclease X"
RHEA:56768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-zeaxanthin + 2 O2 = 2 A + all-trans-adonixanthin + 3 H2O
REACT:R-HSA-9695828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 binds type I TKI (Homo sapiens)
RHEA:33494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine
REACT:R-RNO-8874208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Rattus norvegicus)
REACT:R-CFA-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Canis familiaris)
REACT:R-XTR-351877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 2 (Xenopus tropicalis)
RHEA:60758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cinerin I + CoA => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone
RHEA:64661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate
REACT:R-GGA-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)
RHEA:70428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phenylacetyl-CoA => 2-phenylacetate + CoA + H(+)
RHEA:18599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 oxidized [rubredoxin] => H(+) + NAD(+) + 2 reduced [rubredoxin]
REACT:R-DRE-8873850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD5 binds DCA, LCA (Danio rerio)
REACT:R-SCE-9656947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OGG1beta translocates to mitochondria (Saccharomyces cerevisiae)
REACT:R-GGA-8957241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP73 tetramer translocates to the nucleus (Gallus gallus)
RHEA:39552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)
REACT:R-HSA-5617484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)
REACT:R-BTA-8878654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACP6 hydrolyses MYS-LPA (Bos taurus)
REACT:R-CFA-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Canis familiaris)
RHEA:51433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-aminoethylphosphonate + acetyl-CoA => [(1S)-1-acetamidoethyl]phosphonate + CoA
REACT:R-GGA-6807206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 and OTUD3 deubiquitinate PTEN (Gallus gallus)
RHEA:36886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-8955869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
RHEA:35262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate
REACT:R-HSA-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)
REACT:R-BTA-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Bos taurus)
REACT:R-DRE-379464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DOPAC to form HVA (Danio rerio)
REACT:R-CFA-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Canis familiaris)
RHEA:42559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2819) in 21S rRNA <=> pseudouridine(2819) in 21S rRNA
GO:0052768	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	alpha-1,3-mannosidase activity
GO:0052768	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	1,3-alpha-mannosidase activity
GO:0052768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3-mannosyl-oligosaccharide alpha-D-mannohydrolase activity
GO:0052768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-oligosaccharide 1,3-alpha-mannosidase activity
GO:0052768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity
RHEA:32884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-dihydroartemisinic aldehyde + NADP(+) => (+)-artemisinic aldehyde + H(+) + NADPH
REACT:R-HSA-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Homo sapiens)
RHEA:26522	skos:prefLabel	"2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)"
RHEA:26522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)"
RHEA:26522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O
RHEA:47828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b + H2O = ganglioside GD1b + N-acetylneuraminate
REACT:R-HSA-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Homo sapiens)
REACT:R-CEL-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
REACT:R-MMU-202960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of C-IAP1 (Mus musculus)
REACT:R-DME-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Drosophila melanogaster)
REACT:R-MMU-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Mus musculus)
RHEA:67522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DRE-429663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-BTA-3318486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Bos taurus)
RHEA:56569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine => globoside IV3GalNAc-Gb4Cer + H(+) + UDP
REACT:R-GGA-8855915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Gallus gallus)
RHEA:66802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
EC:3.4.19.12	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ubiquitinyl hydrolase 1"
EC:3.4.19.12	skos:altLabel	"ubiquitin thiolesterase"
EC:3.4.19.12	skos:altLabel	"ubiquitin C-terminal hydrolase"
EC:3.4.19.12	skos:prefLabel	"ubiquitinyl hydrolase 1"
REACT:R-SSC-110351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of SMUG1 glycosylase by APEX1 at the AP site (Sus scrofa)
RHEA:35749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-epizingiberene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-HSA-5250880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botF HC:LC binds SV2A or B or C and GT1b on the target cell surface (Homo sapiens)
REACT:R-DDI-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Dictyostelium discoideum)
RHEA:70892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(out) + L-glutamine(in) + Na(+)(out) => L-asparagine(in) + L-glutamine(out) + Na(+)(in)
RHEA:51466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => deoxycholate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SCE-977324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Saccharomyces cerevisiae)
REACT:R-CFA-5626981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Canis familiaris)
RHEA:12604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-2-aminoadipate <=> 2-oxoadipate + L-glutamate
RHEA:58431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E,E)-2,4-hexadien-1-ol + NADP(+) <=> (E,E)-2,4-hexadienal + H(+) + NADPH
RHEA:19042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] => (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-2022065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPGs are secreted (Drosophila melanogaster)
REACT:R-CFA-373813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR2 binds ligands CXCL1 to 7 (Canis familiaris)
REACT:R-MMU-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Mus musculus)
RHEA:32455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone
GO:0015129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate transmembrane transporter activity
GO:0015129	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
REACT:R-XTR-109380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Xenopus tropicalis)
REACT:R-DME-2090037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(6) (Drosophila melanogaster)
RHEA:59539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoyl-CoA + hydrogencarbonate <=> (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate
REACT:R-DDI-197963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHFR2 reduces FOLA to DHF (Dictyostelium discoideum)
REACT:R-SSC-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Sus scrofa)
RHEA:15672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)
RHEA:30735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate
REACT:R-MMU-6809325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Mus musculus)
REACT:R-BTA-2562541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR4-induced ripoptosome assembly (Bos taurus)
RHEA:44331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octanoylglycerol + H2O <=> glycerol + H(+) + octanoate
RHEA:70340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O => beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose
RHEA:62181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + peregrinol diphosphate => diphosphate + viteagnusin D
REACT:R-MMU-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Mus musculus)
REACT:R-RNO-201648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, Endofin, recruits R-Smad1/5/8 (Rattus norvegicus)
REACT:R-DRE-196857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK2 phosphorylates PanK (Danio rerio)
REACT:R-MMU-202127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS synthesizes NO (Mus musculus)
RHEA:11719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoamide of a dicarboxylate + H2O <=> a dicarboxylate + NH4(+)
RHEA:26042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + GDP-alpha-D-mannose <=> beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)
GO:0050613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D14-sterol reductase activity
GO:0050613	skos:altLabel	"C-14 sterol reductase"
GO:0050613	skos:prefLabel	"Delta(14)-sterol reductase"
GO:0050613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sterol C14-reductase activity
GO:0050613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta14-sterol reductase activity
GO:0050613	skos:altLabel	"sterol C14-reductase"
GO:0050613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity
GO:0050613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH
GO:0050613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Delta(14)-sterol reductase"
GO:0050613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-14 sterol reductase activity
GO:0050613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol C-14 reductase activity
REACT:R-DRE-5696131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC1 deaminates Hist (Danio rerio)
RHEA:69151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermine <=> H2O2 + NH4(+) + spermine monoaldehyde
RHEA:37244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA
REACT:R-DRE-5359451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from SAM to NAM to form MNA (Danio rerio)
RHEA:40833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-CEL-1475022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)
RHEA:71647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O
RHEA:71647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"medium-chain-enoyl-CoA hydratase"
RHEA:71647	skos:prefLabel	"medium-chain-enoyl-CoA hydratase"
RHEA:71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-methyl-L-dopa(in) + L-phenylalanine(out) => 3-O-methyl-L-dopa(out) + L-phenylalanine(in)
REACT:R-HSA-381337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CEBPB in adipogenesis (Homo sapiens)
RHEA:18547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-L-arabinonate
REACT:R-SSC-111962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A,C,D hydrolyse cAMP (Sus scrofa)
RHEA:32926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-(1'-sn-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate
REACT:R-DRE-964800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuromedin-U receptors bind neuromedins U, S (Danio rerio)
GO:0046554	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-malate:NADP+ oxidoreductase activity
GO:0046554	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate NADP dehydrogenase activity
GO:0046554	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-malate dehydrogenase activity
GO:0046554	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP malate dehydrogenase activity
GO:0046554	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-linked malate dehydrogenase activity
GO:0046554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate dehydrogenase (NADP+) activity
GO:0046554	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)
RHEA:63123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenamide + H2O <=> (11Z)-eicosenoate + NH4(+)
RHEA:33293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-6809010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating (Homo sapiens)
RHEA:14349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fucosylgalactoside 3-alpha-galactosyltransferase"
RHEA:14349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP
RHEA:14349	skos:prefLabel	"fucosylgalactoside 3-alpha-galactosyltransferase"
RHEA:14349	skos:altLabel	"histo-blood group B transferase"
RHEA:14349	skos:altLabel	"blood-group substance B-dependent galactosyltransferase"
RHEA:14349	skos:altLabel	"fucosylglycoprotein 3-alpha-galactosyltransferase"
RHEA:14349	skos:altLabel	"glycoprotein-fucosylgalactoside alpha-galactosyltransferase"
RHEA:14349	skos:altLabel	"[blood group substance] alpha-galactosyltransferase"
RHEA:14349	skos:altLabel	"blood-group substance alpha-dependent galactosyltransferase"
RHEA:14349	skos:altLabel	"UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase"
RHEA:14349	skos:altLabel	"UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase"
RHEA:14349	skos:altLabel	"histo-blood substance alpha-dependent galactosyltransferase"
RHEA:14349	skos:altLabel	"B transferase"
REACT:R-SSC-6809287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT12 hydrolyses NADH to NMNH (Sus scrofa)
RHEA:64287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + pyruvate <=> 2-phenylacetaldehyde + L-alanine
RHEA:67609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-methyl-ATP => diphosphate + H(+) + N(6)-methyl-AMP
RHEA:51951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:49204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
RHEA:41200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate
RHEA:40262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenedioyl-CoA + H2O <=> (3S)-hydroxyhexadecanedioyl-CoA
REACT:R-DME-5263614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeOH is reduced to MeSeH by TXNRD1 (Drosophila melanogaster)
RHEA:10364	skos:altLabel	"2-decylhomocitrate synthase"
RHEA:10364	skos:prefLabel	"decylhomocitrate synthase"
RHEA:10364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dodecanoyl-CoA + H2O = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)
RHEA:10364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"decylhomocitrate synthase"
RHEA:10364	skos:altLabel	"3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)"
REACT:R-GGA-5638016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2:ARL3:GDP:UNC119B dissociates (Gallus gallus)
RHEA:41876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O
REACT:R-MMU-8950504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27 binds CRLF1 (Mus musculus)
REACT:R-CFA-390291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + carnitine => acetylcarnitine + CoASH (Canis familiaris)
REACT:R-SSC-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Sus scrofa)
REACT:R-CFA-2395876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
REACT:R-XTR-4086083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of ING2 with SUMO1 (Xenopus tropicalis)
RHEA:47157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,25-dihydroxycholesterol + NAD(+) => 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH
REACT:R-DRE-5660663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 cleaves IL1B precursor (Danio rerio)
REACT:R-DME-8871265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD4 (Drosophila melanogaster)
RHEA:61496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)
REACT:R-HSA-9703434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 fusions recruit PIK3CA through PIK3R1 (Homo sapiens)
REACT:R-RNO-9707505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to CLEC1B dimer (Rattus norvegicus)
RHEA:67489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:45779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetonitrile + 2 H2O <=> (indol-3-yl)acetate + NH4(+)
GO:0140956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K79 trimethylase activity
GO:0140956	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K79 trimethylation
GO:0140956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine
GO:0140956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(79) N-trimethyltransferase"
GO:0140956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone trimethyltransferase activity (H3-K79 specific)
GO:0140956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-H3K79 trimethyltransferase activity
GO:0140956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K79 trimethyltransferase activity
GO:0140956	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K79 trimethylation
GO:0140956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-trimethyltransferase activity (H3-K79 specific)
GO:0140956	skos:prefLabel	"[histone H3]-lysine(79) N-trimethyltransferase"
GO:0140956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone trimethylase activity (H3-K79 specific)
REACT:R-DME-9618021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXG1 binds FOXO:SMAD complexes (Drosophila melanogaster)
REACT:R-XTR-189406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 PBGs bind to form HMB (Xenopus tropicalis)
REACT:R-RNO-109480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Rattus norvegicus)
REACT:R-DME-2160932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 binds phosphorylated PARD6A (Drosophila melanogaster)
REACT:R-MMU-964800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuromedin-U receptors bind neuromedins U, S (Mus musculus)
REACT:R-SSC-74213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APRT catalyzes the conversion of adenine to AMP (Sus scrofa)
RHEA:40223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + H2O = 4,8-dimethylnonanoate + CoA + H(+)
RHEA:70465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2
REACT:R-HSA-9686015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)
REACT:R-HSA-1497866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxynitrite can oxidise BH4 to the BH3 radical (Homo sapiens)
REACT:R-XTR-8855375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dissociates from CSK (Xenopus tropicalis)
REACT:R-DRE-8942101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 monoubiquitinates Histone H2B (Danio rerio)
REACT:R-MMU-109343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Mus musculus)
RHEA:17951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO + H(+) + N-formylanthranilate => 3-hydroxy-1H-quinolin-4-one + O2
REACT:R-BTA-74993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Bos taurus)
RHEA:42321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-GGA-209532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR C-terminal fragment enters endosomes (Gallus gallus)
REACT:R-XTR-873918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of JAK1 (Xenopus tropicalis)
RHEA:38024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocotrienol => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol
RHEA:54305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate => n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)
REACT:R-MMU-975635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCMO1:Fe2+ cleaves betaC to atRAL (Mus musculus)
REACT:R-HSA-5693620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)
REACT:R-XTR-190682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin synthesis (generic) (Xenopus tropicalis)
RHEA:39218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexacosenoyl-CoA + H(+) + NADPH <=> hexacosanoyl-CoA + NADP(+)
RHEA:69668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + luteolin 4'-O-beta-D-glucoside => beta-D-glucose + luteolin
RHEA:29852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N-acetyl-alpha-D-galactosamine => 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP
REACT:R-CFA-9007283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 and PRC1.6 associate with E2F6.com-1 (Canis familiaris)
REACT:R-SSC-5654672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR1 (Sus scrofa)
REACT:R-HSA-5602383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)
REACT:R-SSC-203716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1 complex binds to Nostrin (Sus scrofa)
RHEA:56827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cyclooctat-9-ene-5,7-diol + O2 <=> A + cyclooctatin + H2O
RHEA:61312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:42244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + propanoyl-CoA = 3-oxopentanoyl-[ACP] + CO2 + CoA
REACT:R-GGA-8848618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by the PXN:CRK complex (Gallus gallus)
REACT:R-SCE-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Saccharomyces cerevisiae)
REACT:R-DRE-5691150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFR2 dimer binds 2xholoTF (Danio rerio)
RHEA:44913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (3E)-hexenoyl-CoA + NADP(+)
RHEA:39454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O
REACT:R-BTA-193385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of choloyl-CoA to cholate and CoASH (Bos taurus)
REACT:R-DRE-8949661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Danio rerio)
REACT:R-SSC-1449687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticosteroids bind to CBG in blood (Sus scrofa)
REACT:R-HSA-9646390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Misfolded proteins:HDAC6:Dynein motor binds microtubule (Homo sapiens)
REACT:R-CFA-8942344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 transports FOLA from extracellular region to cytosol (Canis familiaris)
REACT:R-DDI-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Dictyostelium discoideum)
RHEA:65810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CEL-8933446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Caenorhabditis elegans)
REACT:R-GGA-374758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Somatostatin receptors bind somatostatin and cortistatin (Gallus gallus)
RHEA:49752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NAD(+) + proviolacein
RHEA:21295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)
REACT:R-GGA-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Gallus gallus)
RHEA:13052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate <=> D-fructuronate
REACT:R-SSC-8866269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB bind GPCRs (Sus scrofa)
RHEA:28226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-epiaristolochene 1,3-dihydroxylase"
RHEA:28226	skos:altLabel	"EAH"
RHEA:28226	skos:altLabel	"CYP71D20"
RHEA:28226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:28226	skos:altLabel	"5-epi-aristolochene 1,3-dihydroxylase"
RHEA:28226	skos:prefLabel	"5-epiaristolochene 1,3-dihydroxylase"
REACT:R-HSA-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Homo sapiens)
REACT:R-MMU-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Mus musculus)
REACT:R-MMU-6811414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF (Mus musculus)
REACT:R-HSA-9673797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
REACT:R-DRE-8848124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAT3 (Danio rerio)
REACT:R-GGA-9677579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Gallus gallus)
RHEA:15915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + thiamine diphosphate => ATP + thiamine phosphate
RHEA:46594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitriol + H2O + 2 oxidized [adrenodoxin] => alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-HSA-5336422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-mediated endocytosis of DT:HBEGF:CD9 (Homo sapiens)
RHEA:42610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinol + n H(+)(out) + NAD(+) => a plastoquinone + (n+1) H(+)(in) + NADH
GO:0004328	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formamide amidohydrolase activity
GO:0004328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formamide hydrolase activity
GO:0004328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formamidase activity
REACT:R-DRE-5678315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Danio rerio)
RHEA:12543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanine + tRNA(Ala) <=> AMP + diphosphate + L-alanyl-tRNA(Ala)
RHEA:30382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphate
REACT:R-SSC-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Sus scrofa)
RHEA:45453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetradecanoylethanolamine => ethanolamine + tetradecanoate
RHEA:63066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + 4 CoA + tetraacetate lactone => acetyl-CoA + 3 H(+) + 3 malonyl-CoA
RHEA:41573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoxin A4 + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH
RHEA:12589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GM2 (d18:1(4E)) + H(+) + UDP
REACT:R-HSA-9614811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional Activation of the HCMV Genome (Homo sapiens)
REACT:R-DRE-1605595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Danio rerio)
RHEA:14721	skos:prefLabel	"zeatin O-beta-D-xylosyltransferase"
RHEA:14721	skos:altLabel	"zeatin O-xylosyltransferase"
RHEA:14721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zeatin O-beta-D-xylosyltransferase"
RHEA:14721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-xylose + zeatin = H(+) + O-beta-D-xylosylzeatin + UDP
RHEA:14721	skos:altLabel	"uridine diphosphoxylose-zeatin xylosyltransferase"
REACT:R-XTR-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Xenopus tropicalis)
REACT:R-MMU-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Mus musculus)
RHEA:71399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxusin = 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine => (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine
REACT:R-CFA-2029268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of PLCG (Canis familiaris)
REACT:R-RNO-5662608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds cadmium (Rattus norvegicus)
REACT:R-GGA-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Gallus gallus)
RHEA:34821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	curcumin + H(+) + NADPH => dihydrocurcumin + NADP(+)
REACT:R-RNO-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Rattus norvegicus)
REACT:R-HSA-1676048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
REACT:R-BTA-350318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at TNLD (429) (Bos taurus)
REACT:R-BTA-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Bos taurus)
REACT:R-MMU-9021079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs:CAVs translocate to plasma membrane (Mus musculus)
RHEA:25625	skos:altLabel	"semicarbazide-sensitive amine oxidase"
RHEA:25625	skos:altLabel	"amine oxidase"
RHEA:25625	skos:prefLabel	"diamine oxidase"
RHEA:25625	skos:altLabel	"copper amine oxidase"
RHEA:25625	skos:altLabel	"histaminase"
RHEA:25625	skos:altLabel	"CAO"
RHEA:25625	skos:altLabel	"Cu-containing amine oxidase"
RHEA:25625	skos:altLabel	"histamine deaminase"
RHEA:25625	skos:altLabel	"diamino oxhydrase"
RHEA:25625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+)
RHEA:25625	skos:altLabel	"SSAO"
RHEA:25625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diamine oxidase"
RHEA:25625	skos:altLabel	"amine oxidase (copper-containing)"
RHEA:28658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione S,S-dioxide + H2O <=> glutathione + H(+) + sulfite
RHEA:36269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + NAD(+) + theobromine => caffeine + H(+) + NADH + O2
REACT:R-SSC-9025999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Sus scrofa)
GO:0071633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramidase activity
RHEA:14762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + L-serine => 3-oxosphinganine + CO2 + CoA
RHEA:24263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-2-oxohex-3-enedioate + H(+) <=> 2-oxopent-4-enoate + CO2
RHEA:11031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-mannose <=> ADP + D-mannose 6-phosphate + H(+)
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' nucleotidase activity
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	adenosine monophosphatase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uridine 5'-nucleotidase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	AMPase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-ribonucleotide phosphohydrolase activity
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	AMP phosphatase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	5'-AMPase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-nucleotidase activity
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UMPase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	5'-adenylic phosphatase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	adenosine 5'-phosphatase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	5'-AMP nucleotidase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	AMP phosphohydrolase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-mononucleotidase activity
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thimidine monophosphate nucleotidase
GO:0008253	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	snake venom 5'-nucleotidase
RHEA:66977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose => alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)
RHEA:36590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldopyranose + NADP(+) <=> aldono-1,5-lactone + H(+) + NADPH
REACT:R-HSA-6802999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCD is processed into DCD(63-110) (Homo sapiens)
REACT:R-DME-5654423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)
GO:0050563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-feruloyl-CoA synthetase activity
GO:0050563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-ferulate:CoASH ligase (ATP-hydrolysing)
GO:0050563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-feruloyl-CoA synthase activity
GO:0050563	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferulate-CoA ligase activity
GO:0008242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	omega peptidase activity
GO:0008242	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidase activity, acting on peptides containing modified amino acids
REACT:R-PFA-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Plasmodium falciparum)
REACT:R-XTR-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Xenopus tropicalis)
REACT:R-HSA-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Homo sapiens)
REACT:R-XTR-110375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Xenopus tropicalis)
GO:0044019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H3-K72 specific)
GO:0044019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H3-K72 specific)
GO:0044019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K72 acetyltransferase activity
GO:0044019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H3-K72 specific)
GO:0044019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K72 acetyltransferase activity
REACT:R-HSA-9729454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 N protein binds STAT1, STAT2 (Homo sapiens)
REACT:R-BTA-73632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Bos taurus)
RHEA:32789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-ectoine(in) + phosphate => ATP + H2O + L-ectoine(out)
REACT:R-DME-377641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
REACT:R-DME-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Drosophila melanogaster)
RHEA:69193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-glutamyl-[tubulin] => ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate
RHEA:68791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> (Z)-gamma-bisabolene + diphosphate
RHEA:36137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hexadec-2-enoate + 2 H(+) + NADH => (2E)-hexadecenal + H2O + NAD(+)
RHEA:49942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2
REACT:R-DRE-388529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholecystokinin receptors bind cholecystokinin (Danio rerio)
REACT:R-HSA-187020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of pro-beta-NGF is processed to mature beta-NGF (Homo sapiens)
REACT:R-CFA-8852481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Canis familiaris)
REACT:R-SSC-174690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Sus scrofa)
REACT:R-SSC-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Sus scrofa)
RHEA:72855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(out) + dADP(in) = ADP(in) + dADP(out)
REACT:R-DDI-5651773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds POLB at long-patch BER site (Dictyostelium discoideum)
REACT:R-DDI-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Dictyostelium discoideum)
RHEA:67695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + hexadecanedioate(in) <=> ADP + H(+) + hexadecanedioate(out) + phosphate
GO:0099530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential
GO:0099530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
GO:0038200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylene receptor histidine kinase activity
REACT:R-CEL-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Caenorhabditis elegans)
REACT:R-HSA-190541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cx43 with TJP1 (Homo sapiens)
REACT:R-CFA-2002460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4HB binds Collagen chains (Canis familiaris)
REACT:R-DME-6809320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Drosophila melanogaster)
REACT:R-MMU-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)
REACT:R-BTA-1112708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds p-Y759-IL6ST (Bos taurus)
RHEA:52956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP
RHEA:68240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out)
REACT:R-HSA-111439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)
RHEA:15848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP
RHEA:55617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carotenoid psi-end group => a carotenoid epsilon-end group
GO:0015154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	disaccharide transmembrane transporter activity
RHEA:65857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 1-hydroxy-3-oxo steroid => a steroid 1,3-dione + AH2
REACT:R-HSA-2077421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer (Homo sapiens)
RHEA:69952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-6791109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds PCNA (Bos taurus)
REACT:R-BTA-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Bos taurus)
REACT:R-BTA-202966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of HIP-55 (Bos taurus)
RHEA:11065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate
REACT:R-BTA-1564169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VIII degradation by MMP1 (Bos taurus)
RHEA:56746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[protein] + O2
REACT:R-XTR-9724685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds omalizumab (Xenopus tropicalis)
RHEA:31144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH
RHEA:24087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:33758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + hexadecanoate
REACT:R-DRE-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Danio rerio)
REACT:R-BTA-3222237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMYD2 methylates TP53 (Bos taurus)
RHEA:54417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-campestan-3-one + NADP(+) => campest-4-en-3-one + H(+) + NADPH
RHEA:42681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hercynine + 2 L-selenocysteine + O2 => 2 H2O + 2 hercynylselenocysteine
REACT:R-MMU-5654596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)
RHEA:14902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => casbene + diphosphate
RHEA:58283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 ATP <=> cyclic tetraadenylate + 4 diphosphate
GO:0047702	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-beta-lysine 5,6-aminomutase activity
GO:0047702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	b-lysine 5,6-aminomutase activity
GO:0047702	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-lysine mutase activity
GO:0047702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-lysine 5,6-aminomutase activity
GO:0047702	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-3,6-diaminohexanoate 5,6-aminomutase activity
RHEA:43339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) <=> CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)
REACT:R-HSA-174448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Processive Complex on the C-strand of the telomere (Homo sapiens)
REACT:R-DME-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Drosophila melanogaster)
REACT:R-SSC-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Sus scrofa)
REACT:R-SSC-9640254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Sus scrofa)
REACT:R-CFA-8948066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-IRAK1 dissociates (Canis familiaris)
REACT:R-DRE-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Danio rerio)
REACT:R-HSA-9629483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA (Homo sapiens)
REACT:R-SPO-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Schizosaccharomyces pombe)
REACT:R-XTR-981809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Xenopus tropicalis)
REACT:R-DRE-1306965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Danio rerio)
RHEA:15501	skos:altLabel	"glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP)"
RHEA:15501	skos:altLabel	"NADPH-glutamate synthase"
RHEA:15501	skos:altLabel	"GOGAT"
RHEA:15501	skos:altLabel	"L-glutamate synthase"
RHEA:15501	skos:altLabel	"glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase"
RHEA:15501	skos:altLabel	"NADPH-dependent glutamate synthase"
RHEA:15501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate synthase (NADPH)"
RHEA:15501	skos:altLabel	"L-glutamate synthetase"
RHEA:15501	skos:altLabel	"glutamine-ketoglutaric aminotransferase"
RHEA:15501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH
RHEA:15501	skos:prefLabel	"glutamate synthase (NADPH)"
RHEA:15501	skos:altLabel	"glutamate synthetase (NADP)"
REACT:R-RNO-8953013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 binds E2F8 (Rattus norvegicus)
REACT:R-CFA-72095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internal Methylation of mRNA (Canis familiaris)
RHEA:40156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:70219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + H(+) + NADPH = 20beta-dihydrocorticosterone + NADP(+)
REACT:R-XTR-9749647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES2 hydrolyzes ASA- (Xenopus tropicalis)
GO:0004560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-fucosidase activity
GO:0004560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-L-fucoside fucohydrolase activity
GO:0004560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-fucosidase activity
REACT:R-GGA-9639287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2 binds L-leucine and dissociates from GATOR2 (Gallus gallus)
REACT:R-MMU-9007901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RL2 (Mus musculus)
REACT:R-DRE-177935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 dephosphorylates Tyr 992 on EGFR (Danio rerio)
REACT:R-CFA-1474158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCHFR binds to GCH1 and negatively regulates its activity (Canis familiaris)
REACT:R-DME-5205682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parkin promotes the ubiquitination of mitochondrial substrates (Drosophila melanogaster)
REACT:R-DME-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Drosophila melanogaster)
REACT:R-GGA-3323050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNRD2 catalyzes the reduction of TXN2 by NADPH (Gallus gallus)
RHEA:63160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(15Z-tetracosenoyl)-taurine = (15Z)-tetracosenoate + taurine
RHEA:36612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 => (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate
RHEA:54783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
REACT:R-DRE-6804242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the complex of JMY, EP300 and TTC5 (Danio rerio)
RHEA:67890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine
REACT:R-XTR-8856945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A methylation by LCMT1 (Xenopus tropicalis)
RHEA:54553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate
GO:0070012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligopeptidase activity
REACT:R-DRE-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Danio rerio)
RHEA:32219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene = gamma-carotene
REACT:R-BTA-2730856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Bos taurus)
REACT:R-DRE-75126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Danio rerio)
REACT:R-DME-73806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIR + CO2 => CAIR (Drosophila melanogaster)
REACT:R-HSA-983709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)
RHEA:59769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-SSC-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Sus scrofa)
GO:0018456	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	benzyl alcohol dehydrogenase activity
GO:0018456	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p-hydroxybenzyl alcohol dehydrogenase activity
GO:0018456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-alcohol:NAD+ oxidoreductase activity
GO:0018456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryl-alcohol dehydrogenase (NAD+) activity
REACT:R-BTA-2032396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3 migrates to the nucleus (Bos taurus)
RHEA:38702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
RHEA:29190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate + ubiquinone-8 <=> fumarate + ubiquinol-8
REACT:R-CFA-2002428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of fibrillar collagen N-propeptides (Canis familiaris)
REACT:R-DME-9632906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ recruits RAS in response to estrogen stimulation (Drosophila melanogaster)
GO:0103060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity
RHEA:68599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> beta-cadinene + diphosphate
REACT:R-XTR-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Xenopus tropicalis)
RHEA:46067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:57849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + scopoletin => CO2 + fraxetin + succinate
REACT:R-RNO-8948027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial phospholipids (Rattus norvegicus)
REACT:R-RNO-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Rattus norvegicus)
REACT:R-DME-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Drosophila melanogaster)
RHEA:34674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-6807206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 and OTUD3 deubiquitinate PTEN (Dictyostelium discoideum)
REACT:R-MMU-381727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAP1A exchanges GDP for GTP (Mus musculus)
REACT:R-RNO-5686578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates ABL1 (Rattus norvegicus)
REACT:R-SSC-174174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Sus scrofa)
RHEA:67228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA = (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O
REACT:R-CEL-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
GO:0140064	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein crotonyltransferase activity
GO:0140064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide crotonyltransferase activity
GO:0140064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]
RHEA:69728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + ATP + H(+) => diphosphate + phenylacetyl-AMP
REACT:R-HSA-72231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)
RHEA:45400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:45616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine
REACT:R-BTA-2424246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind lecticans (Bos taurus)
REACT:R-SPO-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Schizosaccharomyces pombe)
REACT:R-MMU-350869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Mus musculus)
REACT:R-HSA-6794357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHANK proteins bind GKAPs (Homo sapiens)
REACT:R-RNO-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Rattus norvegicus)
EC:2.6.1.5	skos:altLabel	"TyrAT"
EC:2.6.1.5	skos:prefLabel	"tyrosine transaminase"
EC:2.6.1.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine transaminase"
EC:2.6.1.5	skos:altLabel	"tyrosine aminotransferase"
REACT:R-BTA-351936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of claspin (Bos taurus)
REACT:R-HSA-2022399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Homo sapiens)
REACT:R-SSC-9028255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises EPA to PGH3 (Sus scrofa)
REACT:R-DDI-983144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Antigen peptide in to ER (Dictyostelium discoideum)
RHEA:22411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + isopentenyl diphosphate <=> (2E)-geranyl diphosphate + diphosphate
GO:0140262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA cap binding complex binding
RHEA:54004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
REACT:R-BTA-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Bos taurus)
REACT:R-MMU-1855197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)
REACT:R-XTR-2404134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4:atROL binds TTR (Xenopus tropicalis)
RHEA:40098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-oxohexacosanoate + H2O + NAD(+) <=> 2 H(+) + hexacosanedioate + NADH
REACT:R-MMU-173739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of C3 thioester (Mus musculus)
RHEA:43353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)
REACT:R-HSA-9609917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane (Homo sapiens)
RHEA:38525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O
REACT:R-HSA-9678935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Homo sapiens)
RHEA:52075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)
REACT:R-DRE-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Danio rerio)
REACT:R-CFA-174255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation multiubiquitinated Cyclin A (Canis familiaris)
REACT:R-SSC-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Sus scrofa)
REACT:R-DDI-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Dictyostelium discoideum)
RHEA:17676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + S-adenosyl-L-methionine <=> 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:66870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate => 3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-5654709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
RHEA:61478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-octadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + octadecanoyl-CoA
REACT:R-DRE-5357831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD is phosphorylated by IKK (Danio rerio)
RHEA:30471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate = (1S,5S,6S)-alpha-bergamotene + diphosphate
RHEA:30471	skos:prefLabel	"(-)-endo-alpha-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]"
RHEA:30471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-endo-alpha-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]"
REACT:R-SSC-163764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)
REACT:R-GGA-443831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3-zeta binds Raf1 (Gallus gallus)
RHEA:57498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-cis-aconitate + H2O => 2-methylcitrate
RHEA:47302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-BTA-6788523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to Complex I subunits (Bos taurus)
REACT:R-MMU-983138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC heterotrimer to ER exit site (Mus musculus)
RHEA:34999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(in) + ATP(out) = ADP(out) + ATP(in)
RHEA:36635	skos:altLabel	"tRNA-yW synthesizing enzyme-3"
RHEA:36635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine
RHEA:36635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase"
RHEA:36635	skos:prefLabel	"tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase"
RHEA:30832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose
REACT:R-HSA-1295621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL dissociates from ubiquitinated p-SPRY2 (Homo sapiens)
REACT:R-CFA-180047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates DARPP-32 on Thr75 (Canis familiaris)
RHEA:20417	skos:altLabel	"Oplophorus luciferase"
RHEA:20417	skos:prefLabel	"Oplophorus-luciferin 2-monooxygenase"
RHEA:20417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Oplophorus-luciferin 2-monooxygenase"
RHEA:20417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine + O2 = CO2 + coelenteramide + hnu
REACT:R-MMU-5668414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Mus musculus)
RHEA:52319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)
RHEA:65760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-177671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Gallus gallus)
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanyl-specific RNase activity
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease F1
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase Sa
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease C2
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease T1 activity
GO:0046589	skos:altLabel	"Aspergillus oryzae ribonuclease"
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	binase activity
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease Ch
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease T1"
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase T1
GO:0046589	skos:altLabel	"RNase N1"
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Aspergillus oryzae ribonuclease activity
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease U1
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease N1
GO:0046589	skos:prefLabel	"ribonuclease T1"
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease SA
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase T1 activity
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanyloribonuclease activity
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase N1 activity
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase G
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease N3
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase F1
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease PP1
GO:0046589	skos:altLabel	"RNase N2"
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease guaninenucleotido-2'-transferase (cyclizing)
GO:0046589	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase N2 activity
GO:0046589	skos:altLabel	"guanyloribonuclease"
RHEA:45148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA
REACT:R-CEL-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
REACT:R-CFA-8950410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B:IL12B translocates from ER lumen to the extracellular region (Canis familiaris)
RHEA:67015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate
RHEA:37946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O
REACT:R-SCE-70494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate (Saccharomyces cerevisiae)
EC:7.4.2.3	skos:prefLabel	"mitochondrial protein-transporting ATPase"
EC:7.4.2.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mitochondrial protein-transporting ATPase"
RHEA:49045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protoasukamycin => 4-hydroxyprotoasukamycin + H2O + NAD(+)
REACT:R-HSA-9734670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 binds KPNA1 or KPNA6 (Homo sapiens)
REACT:R-HSA-2028629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Homo sapiens)
REACT:R-XTR-5607751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes (Xenopus tropicalis)
RHEA:67564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + chenodeoxycholate = adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)
RHEA:43692	skos:prefLabel	"[pyruvate, phosphate dikinase] kinase"
RHEA:43692	skos:altLabel	"PPDK regulatory protein"
RHEA:43692	skos:altLabel	"bifunctional dikinase regulatory protein"
RHEA:43692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]
RHEA:43692	skos:altLabel	"pyruvate, phosphate dikinase regulatory protein"
RHEA:43692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[pyruvate, phosphate dikinase] kinase"
RHEA:64777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanylpentan-1-ol-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol
REACT:R-DRE-5662692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is oxidized to dopaquinone by TYR (Danio rerio)
REACT:R-BTA-380311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Plk1 to centrosomes (Bos taurus)
RHEA:11600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CMP = ADP + CDP
REACT:R-XTR-4086132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin phosphoprotein binds integrin alphaVbeta1 (Xenopus tropicalis)
REACT:R-CFA-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Canis familiaris)
RHEA:67927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP
REACT:R-HSA-419033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 binds FGFR-1 (Homo sapiens)
REACT:R-BTA-2024084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS-GAGs translocate to the lysosome for degradation (Bos taurus)
REACT:R-HSA-5334160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UHRF1:Chromatin binds DNMT1 (Homo sapiens)
GO:0070379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high mobility group box 1 binding
GO:0070379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binding
GO:1990137	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peroxygenase activity
GO:1990137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plant seed peroxidase activity
REACT:R-CFA-165026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Canis familiaris)
REACT:R-DRE-5690790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H2A is dubiquitinated by the PR-DUB complex (Danio rerio)
REACT:R-BTA-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Bos taurus)
REACT:R-SSC-8877311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB31 GEFs exchange GTP for GDP on RAB31 (Sus scrofa)
REACT:R-CFA-9009526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Canis familiaris)
GO:0008758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2,3-diacylglucosamine hydrolase activity
RHEA:30865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + phosphate => 4-O-phospho-L-tyrosine + H2O
REACT:R-DME-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)
REACT:R-CFA-164617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of Extended Telomeric Chromosome End (Canis familiaris)
REACT:R-GGA-166038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-bound CD14 binds LPS (Gallus gallus)
REACT:R-DRE-507870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water out of cells (Danio rerio)
REACT:R-DME-5609665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
REACT:R-SSC-6808487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)
REACT:R-CEL-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Caenorhabditis elegans)
REACT:R-SSC-5623513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 stimulates GTPase activity of ARF4 (Sus scrofa)
REACT:R-SSC-2404195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Sus scrofa)
RHEA:13217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate
RHEA:64146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-methionine => H2O + N-(9Z-octadecenoyl)-L-methionine
REACT:R-HSA-9755354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 forms a homodimer (Homo sapiens)
GO:0047673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate N-malonyltransferase activity
GO:0047673	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:anthranilate N-malonyltransferase activity
REACT:R-HSA-3076905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular BTD hydrolyses BCTN (Homo sapiens)
GO:0005300	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	high-affinity tryptophan transporter activity
GO:0005300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity tryptophan transmembrane transporter activity
REACT:R-XTR-176669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Xenopus tropicalis)
RHEA:69657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + quercetin => H2O + quercetin 3-O-beta-D-glucoside
RHEA:23359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-seryl-[rhodopsin]
EC:2.7.10.1	skos:prefLabel	"receptor protein-tyrosine kinase"
EC:2.7.10.1	skos:altLabel	"receptor protein tyrosine kinase"
EC:2.7.10.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"receptor protein-tyrosine kinase"
REACT:R-MMU-389523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTLA interacts with HVEM (Mus musculus)
RHEA:15172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-succinyl-L-glutamate <=> L-glutamate + succinate
REACT:R-SSC-6814418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL promotes formation of G-beta:G-gamma heterodimers (Sus scrofa)
REACT:R-HSA-1912401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH4 gene transcription (Homo sapiens)
RHEA:29903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type D-ribose transporter"
RHEA:29903	skos:altLabel	"D-ribose transporting ATPase"
RHEA:29903	skos:prefLabel	"ABC-type D-ribose transporter"
RHEA:29903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) + phosphate
RHEA:29903	skos:altLabel	"D-ribose ABC transporter"
REACT:R-DME-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Drosophila melanogaster)
REACT:R-SSC-2028675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Sus scrofa)
REACT:R-SSC-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Sus scrofa)
GO:0047471	skos:altLabel	"trehalose synthase"
GO:0047471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose = alpha,alpha-trehalose
GO:0047471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltose glucosylmutase activity
GO:0047471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose alpha-D-glucosyltransferase activity
GO:0047471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose synthase activity
GO:0047471	skos:prefLabel	"maltose alpha-D-glucosyltransferase"
GO:0047471	skos:altLabel	"maltose glucosylmutase"
GO:0047471	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltose alpha-D-glucosylmutase activity
GO:0047471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"maltose alpha-D-glucosyltransferase"
REACT:R-CFA-193656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with RIP2 (Canis familiaris)
REACT:R-XTR-5682044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT5 acetylates ATM at DNA DSBs (Xenopus tropicalis)
REACT:R-HSA-9730505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 3a binds to UVRAG (Homo sapiens)
REACT:R-RNO-8871260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD2 (Rattus norvegicus)
REACT:R-SCE-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Saccharomyces cerevisiae)
REACT:R-GGA-1222376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX2 generates superoxide from oxygen (Gallus gallus)
RHEA:30526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-glutamate + oxidized coenzyme F420-1 <=> GDP + H(+) + oxidized coenzyme F420-2 + phosphate
REACT:R-HSA-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Homo sapiens)
GO:0102425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin 3-O-glucosyltransferase activity
RHEA:18317	skos:prefLabel	"amino-acid racemase"
RHEA:18317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid = a D-alpha-amino acid
RHEA:18317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amino-acid racemase"
REACT:R-HSA-5357904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
RHEA:57282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA => a guanosine in RNA + glyoxal
REACT:R-CFA-4570553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MDC1 with SUMO2,3 (Canis familiaris)
GO:0001048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase IV core binding
RHEA:72142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(in) + H(+)(out) <=> estrone 3-sulfate(out) + H(+)(in)
REACT:R-MMU-8948230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P3HB binds 4-Hyp-collagen propeptides (Mus musculus)
RHEA:12872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (4S)-limonene + diphosphate
REACT:R-BTA-202216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 (Bos taurus)
REACT:R-GGA-1358792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates activated ERBB3 (Gallus gallus)
RHEA:23356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[rhodopsin] = ADP + H(+) + O-phospho-L-seryl-[rhodopsin]
REACT:R-DDI-450346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
RHEA:65007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + decanoate + holo-[ACP] <=> AMP + decanoyl-[ACP] + diphosphate
RHEA:39435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)
RHEA:12714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 5'-phosphate + ATP => a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)
RHEA:36082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine
RHEA:29589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH => 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+)
REACT:R-CFA-170087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Canis familiaris)
REACT:R-HSA-9707523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to BACH1:MAFK (Homo sapiens)
REACT:R-MMU-2395328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP1, LTBP3 bind TGF-Beta (Mus musculus)
RHEA:47282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-GGA-194518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoA is activated by nucleotide exchange and inhibits axonal growth (Gallus gallus)
REACT:R-DME-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
REACT:R-RNO-9708466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y486 BACH1 translocates from the nucleoplasm to the cytosol (Rattus norvegicus)
RHEA:29117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + NADP(+) => H(+) + menaquinone-8 + NADPH
REACT:R-CEL-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Caenorhabditis elegans)
REACT:R-RNO-9670114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H3.3 deposition at telomere (Rattus norvegicus)
REACT:R-HSA-9010074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane (Homo sapiens)
REACT:R-MMU-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)
REACT:R-RNO-9018794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds effectors at the plasma membrane (Rattus norvegicus)
REACT:R-HSA-72107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal E complex (Homo sapiens)
RHEA:41007	skos:prefLabel	"6-linalyl-2-O,3-dimethylflaviolin synthase"
RHEA:41007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin = 6-linalyl-2-O,3-dimethylflaviolin + diphosphate
RHEA:41007	skos:altLabel	"6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase"
RHEA:41007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-linalyl-2-O,3-dimethylflaviolin synthase"
REACT:R-GGA-5655835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Gallus gallus)
RHEA:72286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
REACT:R-XTR-209910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is taken up by thyroid epithelial cells (Xenopus tropicalis)
REACT:R-DDI-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Dictyostelium discoideum)
RHEA:65065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + siccayne => diphosphate + pestalodiol
RHEA:72328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate => 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
RHEA:10856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP
REACT:R-DRE-5696119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)
REACT:R-XTR-5623525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo-carrying vesicles bud from the TGN (Xenopus tropicalis)
REACT:R-BTA-448702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-1 active tetramer formation (Bos taurus)
REACT:R-HSA-8936616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
RHEA:41189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O
RHEA:36210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA
REACT:R-SSC-8853419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 promotes AURKA autophosphorylation (Sus scrofa)
REACT:R-MMU-749448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
REACT:R-CEL-177937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of EGFR by SRC kinase (Caenorhabditis elegans)
REACT:R-MMU-5654157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR2 (Mus musculus)
RHEA:34155	skos:prefLabel	"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase"
RHEA:34155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase"
RHEA:34155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose
REACT:R-GGA-74872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,11 oxidise 11cROL to 11cRAL (Gallus gallus)
RHEA:59618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + L-arginine => beta-alanyl-L-arginine + H2O
REACT:R-CEL-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Caenorhabditis elegans)
REACT:R-RNO-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Rattus norvegicus)
RHEA:37156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA
EC:1.1.1.353	skos:prefLabel	"versiconal hemiacetal acetate reductase"
EC:1.1.1.353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"versiconal hemiacetal acetate reductase"
EC:1.1.1.353	skos:altLabel	"VHA reductase"
RHEA:41822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexanoyl-[ACP] + CO2 + holo-[ACP] => butanoyl-[ACP] + H(+) + malonyl-[ACP]
REACT:R-RNO-264848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoA-I binds to CUBN:AMN (Rattus norvegicus)
RHEA:44385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA => 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-RNO-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Rattus norvegicus)
RHEA:15353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin + L-ascorbate = all-trans-antheraxanthin + H2O + L-dehydroascorbate
REACT:R-RNO-8852351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 promotes translocation of TP53 to the cytosol (Rattus norvegicus)
REACT:R-CFA-5610735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB binds ITCH (Canis familiaris)
REACT:R-RNO-9714480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the mitochondrial membrane (Rattus norvegicus)
REACT:R-SSC-4084903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen types VI, IX bind integrin alpha10beta1 (Sus scrofa)
EC:3.4.16.2	skos:altLabel	"lysosomal carboxypeptidase C"
EC:3.4.16.2	skos:prefLabel	"lysosomal Pro-Xaa carboxypeptidase"
EC:3.4.16.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysosomal Pro-Xaa carboxypeptidase"
EC:3.4.16.2	skos:altLabel	"prolyl carboxypeptidase"
EC:3.4.16.2	skos:altLabel	"angiotensinase C"
EC:3.4.16.2	skos:altLabel	"proline carboxypeptidase"
EC:3.4.16.2	skos:altLabel	"lysosomal Pro-X carboxypeptidase"
REACT:R-DRE-5696197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT2 hydrolyses GP4G to GTP, GMP (Danio rerio)
REACT:R-DME-8871227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA4 (Drosophila melanogaster)
REACT:R-GGA-5654734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Gallus gallus)
REACT:R-DRE-8850831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates KLK8 (Danio rerio)
GO:0140830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-glutamine(out) + Na(+)(out) = H(+)(out) + L-glutamine(in) + Na(+)(in)
GO:0140830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine, sodium:proton antiporter activity
REACT:R-MMU-5684108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 binds phosphorylated RBBP8 (Mus musculus)
RHEA:15509	skos:altLabel	"N-acetylglucosaminyltransferase III"
RHEA:15509	skos:altLabel	"GnTIII"
RHEA:15509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase"
RHEA:15509	skos:prefLabel	"beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase"
RHEA:15509	skos:altLabel	"GlcNAc-T III"
RHEA:15509	skos:altLabel	"uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III"
RHEA:15509	skos:altLabel	"N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III"
RHEA:15509	skos:altLabel	"beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase"
RHEA:15509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:61620	skos:prefLabel	"beta-1,2-mannooligosaccharide synthase"
RHEA:61620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose = [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)
RHEA:61620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-1,2-mannooligosaccharide synthase"
RHEA:67356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA = (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA
GO:0030506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ankyrin binding
REACT:R-DDI-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Dictyostelium discoideum)
REACT:R-DME-5696408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Drosophila melanogaster)
REACT:R-DRE-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Danio rerio)
GO:0005228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular sodium activated potassium channel activity
REACT:R-HSA-5649800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)
REACT:R-HSA-1225919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (Homo sapiens)
RHEA:70277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + sucrose => H2O + raffinose
REACT:R-SSC-140847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Sus scrofa)
RHEA:40538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]
RHEA:60367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + myo-inositol(out) <=> H(+)(in) + myo-inositol(in)
RHEA:12663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-hexadecanoyl-(R)-carnitine => (R)-carnitine + hexadecanoyl-CoA
REACT:R-CFA-5682983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates WHSC1 (Canis familiaris)
RHEA:64715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + NADP(+) <=> H(+) + NADPH + propanal
RHEA:59854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH
RHEA:50107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-taurine
RHEA:62052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)
REACT:R-XTR-1181153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Xenopus tropicalis)
RHEA:41815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-[ACP] + H(+) + NADPH <=> butanoyl-[ACP] + NADP(+)
RHEA:58186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14E,18E)-lycopadiene + 2 diphosphate + NADP(+) => H(+) + NADPH + 2 phytyl diphosphate
RHEA:69301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => benzyl isothiocyanate + sulfate
RHEA:42977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan => 2-aminoprop-2-enoate + indole
REACT:R-SCE-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Saccharomyces cerevisiae)
RHEA:37278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-glutamine <=> L-alanine + L-glutamine
RHEA:34430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-lariciresinol + NADP(+) <=> (-)-pinoresinol + H(+) + NADPH
RHEA:42657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphthine methyl ester-[translation elongation factor 2] + H2O => diphthine-[translation elongation factor 2] + H(+) + methanol
REACT:R-HSA-4551661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates RNF168 with SUMO1 (Homo sapiens)
REACT:R-CEL-5333658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLAT:AP1:CLVS bind PI(3,5)P2 (Caenorhabditis elegans)
RHEA:54213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine
REACT:R-SPO-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)
GO:0106310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein serine kinase activity
GO:0106310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-serine kinase activity
GO:0106310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
REACT:R-HSA-400267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins (Homo sapiens)
REACT:R-GGA-75146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)
RHEA:11935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanenitrile <=> acetone + hydrogen cyanide
EC:4.3.1.25	skos:altLabel	"bifunctional PAL"
EC:4.3.1.25	skos:prefLabel	"phenylalanine/tyrosine ammonia-lyase"
EC:4.3.1.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine/tyrosine ammonia-lyase"
EC:4.3.1.25	skos:altLabel	"PTAL"
REACT:R-XTR-443418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b signaling involves c-Src (Xenopus tropicalis)
REACT:R-DRE-8953339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNPH1 hydrolyses dGMP (Danio rerio)
REACT:R-CFA-9633044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR binds STRN (Canis familiaris)
REACT:R-MMU-5694494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)
REACT:R-DDI-8870352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Dictyostelium discoideum)
REACT:R-BTA-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Bos taurus)
REACT:R-CFA-9645520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Canis familiaris)
REACT:R-DME-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Drosophila melanogaster)
REACT:R-RNO-2468041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Rattus norvegicus)
RHEA:18773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] = Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-CFA-3364014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SET1 methyltransferase complex (Canis familiaris)
REACT:R-BTA-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Bos taurus)
REACT:R-XTR-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Xenopus tropicalis)
RHEA:21451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] <=> 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate
REACT:R-SCE-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Saccharomyces cerevisiae)
RHEA:32337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-fenchone + H(+) + NADPH => (1S,2S,4R)-endo-fenchol + NADP(+)
EC:6.5.1.7	skos:prefLabel	"DNA ligase (ATP, ADP or GTP)"
EC:6.5.1.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA ligase (ATP, ADP or GTP)"
RHEA:17028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + xylitol <=> H(+) + L-xylulose + NADPH
RHEA:52156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:52156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylacetaldehyde oxime monooxygenase"
RHEA:52156	skos:altLabel	"CYP71AN24"
RHEA:52156	skos:prefLabel	"phenylacetaldehyde oxime monooxygenase"
REACT:R-HSA-8852362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds CDKN1A (Homo sapiens)
REACT:R-RNO-420595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-2:Nectin 3 trans heterodimer interaction (Rattus norvegicus)
REACT:R-DRE-4086083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of ING2 with SUMO1 (Danio rerio)
RHEA:65332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + verruculide A = chrodrimanin E + H2O + NADP(+)
REACT:R-PFA-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Plasmodium falciparum)
RHEA:21727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nitrile + 2 H2O <=> a carboxylate + NH4(+)
RHEA:56089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + globoside MSGG => CMP + globoside DSGG + H(+)
REACT:R-BTA-201631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 3 (Bos taurus)
REACT:R-MMU-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Mus musculus)
RHEA:36844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA
REACT:R-CEL-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Caenorhabditis elegans)
GO:0043841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate 2-kinase activity
GO:0043841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate 2-kinase activity
REACT:R-HSA-113442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites (Homo sapiens)
REACT:R-XTR-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Xenopus tropicalis)
RHEA:58811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP + 2 H2O <=> AMP + GMP + 2 H(+)
REACT:R-DDI-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Dictyostelium discoideum)
RHEA:37654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:10662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-seryl-[protein] => L-seryl-[protein]
REACT:R-CFA-8862090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Canis familiaris)
REACT:R-DRE-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Danio rerio)
REACT:R-GGA-389348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by pVav1 (Gallus gallus)
RHEA:63883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + thiocyanate <=> cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur
RHEA:39134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA
GO:0004720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysyl oxidase activity
GO:0004720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-lysine 6-oxidase activity
GO:0004720	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
REACT:R-SSC-5672083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KTN1 binds Kinesin-1 (Sus scrofa)
REACT:R-DRE-1168445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B binds the GH receptor complex (Danio rerio)
RHEA:28734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-leucine(in) <=> H(+)(in) + L-leucine(out)
RHEA:68747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine
REACT:R-SSC-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Sus scrofa)
RHEA:27967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate + H2O => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate
REACT:R-GGA-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Gallus gallus)
GO:0033947	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-beta-mannosidase activity
GO:0033947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosylglycoprotein endo-beta-mannosidase activity
REACT:R-BTA-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Bos taurus)
REACT:R-SPO-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)
REACT:R-BTA-975311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Bos taurus)
REACT:R-DME-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Drosophila melanogaster)
REACT:R-DME-77303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Drosophila melanogaster)
REACT:R-HSA-6786092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4:IL4R:JAK2 binds IL2RG:JAK3 (Homo sapiens)
REACT:R-GGA-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Gallus gallus)
RHEA:71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate(out) <=> glycoursodeoxycholate(in)
RHEA:47797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aralkylamine + H2O + 2 oxidized [azurin] => an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]
RHEA:45318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta-prostaglandin F2 + NADP(+) => H(+) + NADPH + prostaglandin D2
REACT:R-SSC-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Sus scrofa)
REACT:R-SCE-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Saccharomyces cerevisiae)
REACT:R-RNO-9708457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HM13 cleaves HMOX1 dimer (Rattus norvegicus)
REACT:R-HSA-9014812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBOs bind keratan sulfate (Homo sapiens)
REACT:R-BTA-380905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serotonin loaded synaptic vesicle docking and priming (Bos taurus)
REACT:R-DME-141341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMOX-3 oxidises SPN to SPM (Drosophila melanogaster)
RHEA:55943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-3,4-didehydroretinol + NAD(+) <=> all-trans-3,4-didehydroretinal + H(+) + NADH
REACT:R-RNO-6806629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tonofilament bundles (Rattus norvegicus)
RHEA:25778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inosine => scyllo-inosose
RHEA:13662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formimidoyl-L-aspartate => N-formyl-L-aspartate + NH4(+)
REACT:R-CEL-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Caenorhabditis elegans)
RHEA:54694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-yl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
GO:0070733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine monophosphate-protein transferase activity
GO:0070733	skos:prefLabel	"protein adenylyltransferase"
GO:0070733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate
GO:0070733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein adenylyltransferase"
GO:0070733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMPylator
GO:0070733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein adenylyltransferase activity
EC:2.1.1.42	skos:prefLabel	"flavone 3'-O-methyltransferase"
EC:2.1.1.42	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavone 3'-O-methyltransferase"
EC:2.1.1.42	skos:altLabel	"o-dihydric phenol methyltransferase"
EC:2.1.1.42	skos:altLabel	"quercetin 3'-O-methyltransferase"
REACT:R-BTA-8950724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Bos taurus)
REACT:R-MMU-5205861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Mus musculus)
RHEA:16526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)
RHEA:44674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O
REACT:R-CFA-8875591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK7 activates RAC1 (Canis familiaris)
RHEA:23962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 3 H2O + pentadecanal => H(+) + 2 H2O2 + hexadecanoate
REACT:R-HSA-375776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Homo sapiens)
RHEA:32092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine => dTDP + erythromycin D + H(+)
RHEA:57208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + L-cysteinyl-[protein] = S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]
RHEA:44487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-77592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Intronless Pre-mRNA at 3'-end (Rattus norvegicus)
REACT:R-MMU-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Mus musculus)
REACT:R-SSC-2424484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BTK by p-SYK (Sus scrofa)
RHEA:11174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + L-methionine => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine
REACT:R-CFA-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)
RHEA:22119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP
REACT:R-CFA-75873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of Nucleotides 5 through 9 on the growing Transcript (Canis familiaris)
REACT:R-MMU-389354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Vav1 (Mus musculus)
RHEA:14321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	morphine + NADP(+) = H(+) + morphinone + NADPH
REACT:R-BTA-9710353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds cardiolipin (Bos taurus)
REACT:R-DRE-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Danio rerio)
REACT:R-GGA-5607733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 binds CARD9 (Gallus gallus)
REACT:R-DRE-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Danio rerio)
RHEA:42595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
GO:0031434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitogen-activated protein kinase kinase binding
GO:0031434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKK binding
RHEA:48132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate
REACT:R-HSA-8955289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
REACT:R-RNO-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Rattus norvegicus)
RHEA:18701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite + H2O + 2 oxidized [azurin] = arsenate + 3 H(+) + 2 reduced [azurin]
RHEA:18701	skos:prefLabel	"arsenate reductase (azurin)"
RHEA:18701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arsenate reductase (azurin)"
RHEA:18701	skos:altLabel	"arsenite oxidase"
REACT:R-CFA-9035227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN2 binds CysS248-MPST (Canis familiaris)
REACT:R-RNO-8944262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type X (Rattus norvegicus)
RHEA:25158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + ATP + L-cysteine
GO:0004513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity
GO:0004513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sialyltransferase 3
GO:0004513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neolactotetraosylceramide alpha-2,3-sialyltransferase activity
GO:0004513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SAT-3
GO:0004513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity
REACT:R-PFA-1675949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)
REACT:R-BTA-5654714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
REACT:R-HSA-1222597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loaded mycobactin gets imported (Homo sapiens)
RHEA:28381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-fructosyl)-L-lysine <=> ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine
RHEA:57751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH <=> C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
GO:0044016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K4 acetyltransferase activity
GO:0044016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H3-K4 specific)
GO:0044016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H3-K4 specific)
GO:0044016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H3-K4 specific)
GO:0044016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K4 acetyltransferase activity
REACT:R-GGA-3296301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCRL2 binds CCL19 (Gallus gallus)
RHEA:45970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+) => androst-4-ene-3,17-dione + H(+) + NADH + O2
REACT:R-GGA-8982637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins binds G alpha-t (Gallus gallus)
RHEA:65188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + berkeleyone B + O2 = berkeleydione + CO2 + H2O + succinate
REACT:R-DRE-9759169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Danio rerio)
REACT:R-BTA-8874080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates PTK2 (Bos taurus)
GO:0015530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	shikimate transmembrane transporter activity
RHEA:37171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
RHEA:50572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]
RHEA:64600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base
REACT:R-DRE-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Danio rerio)
RHEA:41398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine
RHEA:35252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate
RHEA:47035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA <=> 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]
GO:0043495	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein membrane anchor
GO:0043495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein membrane adaptor
GO:0043495	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anchoring
GO:0043495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein membrane adaptor activity
GO:0043495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-membrane adaptor activity
REACT:R-GGA-9708457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HM13 cleaves HMOX1 dimer (Gallus gallus)
RHEA:32953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalulose => sucrose
REACT:R-MMU-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Mus musculus)
RHEA:23205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorogenate + D-glucarate => 2-O-caffeoylglucarate + L-quinate
RHEA:13333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 2-phosphate + phosphate
RHEA:13333	skos:prefLabel	"fructose-2,6-bisphosphate 6-phosphatase"
RHEA:13333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructose-2,6-bisphosphate 6-phosphatase"
RHEA:20952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:20952	skos:prefLabel	"N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase"
RHEA:20952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase"
REACT:R-GGA-1227885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1/IKK epsilon bind to TANK:TRAF3/TRAF6 complex followed by their activation (Gallus gallus)
REACT:R-CEL-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)
REACT:R-XTR-177943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to EGF:EGFR complex (Xenopus tropicalis)
RHEA:41683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) <=> a 2-all-trans-polyprenylphenol + CO2
GO:0102843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming)
REACT:R-RNO-8944254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVI (Rattus norvegicus)
REACT:R-CEL-6783880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIPOX oxidises PPCA to P6C (Caenorhabditis elegans)
REACT:R-MMU-8987141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Mus musculus)
REACT:R-BTA-372819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Bos taurus)
RHEA:54373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (+)-(2S,3R,9R)-pristinol + diphosphate
REACT:R-RNO-111930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase produces cAMP (Rattus norvegicus)
RHEA:47183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) <=> (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH
REACT:R-CFA-1006143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C3b (Canis familiaris)
RHEA:69943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol
GO:0102694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinetin UDP glycosyltransferase activity
REACT:R-HSA-9008315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen (Homo sapiens)
REACT:R-CFA-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)
REACT:R-CFA-211966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2D6 4-hydroxylates debrisoquine (Canis familiaris)
REACT:R-DDI-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Dictyostelium discoideum)
RHEA:61895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)
REACT:R-HSA-2426153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C binds the ACACB promoter (Homo sapiens)
REACT:R-HSA-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Homo sapiens)
REACT:R-DME-5654667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
REACT:R-HSA-199154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD200 binds to CD200R (Homo sapiens)
REACT:R-DME-5617828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIP11:IFT20 dissociates (Drosophila melanogaster)
GO:0052753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopropanol:coenzyme F420 oxidoreductase activity
GO:0052753	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	F420-dependent secondary alcohol dehydrogenase activity
GO:0052753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propan-2-ol:coenzyme F420 oxidoreductase activity
GO:0052753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F420-dependent propan-2-ol dehydrogenase activity
RHEA:15514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + keto-D-tagatose => ADP + H(+) + keto-D-tagatose 6-phosphate
RHEA:16884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate
REACT:R-MMU-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Mus musculus)
GO:0071567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deUFMylase activity
GO:0071567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UFM1 hydrolase activity
REACT:R-XTR-8948228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)
RHEA:41592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)
RHEA:67418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-2046089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Rattus norvegicus)
REACT:R-XTR-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Xenopus tropicalis)
REACT:R-CFA-5691154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HFE binds TFRC dimer (Canis familiaris)
REACT:R-SCE-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Saccharomyces cerevisiae)
REACT:R-GGA-419389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA-binding receptors bind LPA (Gallus gallus)
GO:0080046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 4'-O-glucosyltransferase activity
REACT:R-HSA-6799178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
RHEA:66453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) => 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH
RHEA:31185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-CoA + CoA => acetyl-CoA + decanoyl-CoA
REACT:R-HSA-1791143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of YIF1A (Homo sapiens)
REACT:R-XTR-548800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Xenopus tropicalis)
REACT:R-XTR-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Xenopus tropicalis)
RHEA:49126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + protoviolaceinate => H(+) + NADPH + O2 + protodeoxyviolaceinate
RHEA:26227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-oate + 2 H(+) + NADH => abieta-7,13-dien-18-al + H2O + NAD(+)
RHEA:52286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:27509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cocaine + H2O <=> benzoate + ecgonine methyl ester + H(+)
REACT:R-RNO-9033509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X binds Ub:PEX5L (Rattus norvegicus)
REACT:R-XTR-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Xenopus tropicalis)
REACT:R-DRE-9707690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 binds MAFK (Danio rerio)
REACT:R-XTR-8862733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR2, CCR3 bind CCL13 (Xenopus tropicalis)
RHEA:65161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + hexan-2-ol => CoA + hexan-2-yl benzoate
REACT:R-GGA-419451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate (Gallus gallus)
RHEA:46971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydroisopentenyldehydrorhodopin <=> AH2 + isopentenyldehydrorhodopin
REACT:R-RNO-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)
RHEA:45805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydroxylamine + L-glutamate => ADP + L-glutamine hydroxamate + phosphate
REACT:R-DRE-5654425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds SHC1 (Danio rerio)
RHEA:52913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dimethylallyl-4-hydroxymandelate + O2 => 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O
REACT:R-CFA-9677320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS1 dimer binds PTGS1 Inhibitors (Canis familiaris)
REACT:R-DDI-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Dictyostelium discoideum)
RHEA:70723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sitosterol(out) = sitosterol(in)
RHEA:38831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine
RHEA:66698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine
REACT:R-RNO-5688837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 deubiquitinates polyUb-PARK2 (Rattus norvegicus)
REACT:R-DDI-5672965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GEFs promote RAS nucleotide exchange (Dictyostelium discoideum)
RHEA:66784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) = 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]
RHEA:59310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactonate + H(+) => D-galactono-1,5-lactone + H2O
RHEA:15028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine
RHEA:51958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylpropanal oxime => (E)-2-methylpropanal oxime
REACT:R-DME-380905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serotonin loaded synaptic vesicle docking and priming (Drosophila melanogaster)
REACT:R-BTA-1638821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
REACT:R-MMU-433131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaDC1 co-transports dicarboxylic acids and a sodium ion (Mus musculus)
RHEA:15349	skos:altLabel	"acetylglutamate-acetylornithine transacetylase"
RHEA:15349	skos:altLabel	"ornithine acetyltransferase"
RHEA:15349	skos:altLabel	"N-acetylglutamate synthase"
RHEA:15349	skos:altLabel	"glutamate acetyltransferase"
RHEA:15349	skos:altLabel	"acetylornithine glutamate acetyltransferase"
RHEA:15349	skos:altLabel	"acetylglutamic synthetase"
RHEA:15349	skos:altLabel	"N-acetyl-L-glutamate synthetase"
RHEA:15349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate N-acetyltransferase"
RHEA:15349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate
RHEA:15349	skos:altLabel	"N-acetylglutamate synthetase"
RHEA:15349	skos:altLabel	"ornithine transacetylase"
RHEA:15349	skos:altLabel	"acetylglutamate synthetase"
RHEA:15349	skos:altLabel	"acetylglutamic-acetylornithine transacetylase"
RHEA:15349	skos:prefLabel	"glutamate N-acetyltransferase"
REACT:R-HSA-2426150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds the HMGCS1 promoter (Homo sapiens)
RHEA:57572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Mus musculus)
RHEA:28675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose = beta-D-galactose
RHEA:49138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionyl-S-oxide-[protein] + NADP(+) => H(+) + L-methionyl-[protein] + NADPH + O2
RHEA:17634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucuronoside + H2O => an alcohol + D-glucuronate
EC:1.1.1.51	skos:prefLabel	"3(or 17)beta-hydroxysteroid dehydrogenase"
EC:1.1.1.51	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3(or 17)beta-hydroxysteroid dehydrogenase"
RHEA:26279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-4 + S-adenosyl-L-methionine
REACT:R-DDI-174104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Dictyostelium discoideum)
RHEA:30053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluoride + glycolate + H(+) => fluoroacetate + H2O
REACT:R-DRE-8985929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Danio rerio)
REACT:R-HSA-9768937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 gene transcription is stimulated by NPAS4 (Homo sapiens)
REACT:R-DRE-8954082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds the PRC1 complex (Danio rerio)
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleosidase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IAG-NH activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	nucleosidase g activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine-nucleoside ribohydrolase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-ribosyl purine ribohydrolase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine nucleoside hydrolase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IAG-nucleoside hydrolase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonucleoside hydrolase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine nucleosidase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine ribonucleosidase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine beta-ribosidase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-D-ribosylpurine ribohydrolase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	inosine-adenosine-guanosine preferring nucleoside hydrolase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine nucleosidase reaction
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	purine-specific nucleoside N-ribohydrolase activity
GO:0008477	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	nucleoside hydrolase activity
REACT:R-DRE-5692775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Danio rerio)
RHEA:14684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-aminophenol + A + O2 <=> 2-aminophenoxazin-3-one + AH2 + 2 H2O
GO:0046917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity
GO:0046917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CitG activity
GO:0046917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:dephospho-CoA 5-triphosphoribosyl transferase activity
GO:0046917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triphosphoribosyl-dephospho-CoA synthase activity
GO:0046917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity
REACT:R-DDI-8870489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA4,(5,6) bind PI3P (Dictyostelium discoideum)
REACT:R-XTR-70555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Xenopus tropicalis)
RHEA:18427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate + H(+) + NADPH => L-quinate + NADP(+)
RHEA:56331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O <=> 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)
RHEA:55031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine <=> an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine
RHEA:38330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol
REACT:R-DME-2130286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Drosophila melanogaster)
REACT:R-SCE-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Saccharomyces cerevisiae)
RHEA:28392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-fructosyl)-L-lysine => N(6)-(D-psicosyl)-L-lysine
REACT:R-BTA-265423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Fibrillin (Bos taurus)
REACT:R-DRE-1358801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds RNF41 ubiquitin ligase (Danio rerio)
RHEA:20622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Zn(2+)(in) => ADP + H(+) + phosphate + Zn(2+)(out)
RHEA:44441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,3-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol
REACT:R-HSA-448962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of E proteins with Myod (Homo sapiens)
RHEA:30778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pyridoxamine <=> H2O2 + NH4(+) + pyridoxal
RHEA:39512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O
GO:0004068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate 1-decarboxylase activity
GO:0004068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate 1-carboxy-lyase (beta-alanine-forming)
GO:0004068	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aspartic alpha-decarboxylase
GO:0004068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate alpha-decarboxylase activity
GO:0004068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate alpha-decarboxylase activity
GO:0004068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate 1-carboxy-lyase activity
GO:0061676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	importin-alpha family protein binding
RHEA:70257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine => 1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol
GO:0044595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decaprenyldihydroxybenzoate methyltransferase activity
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA reductase activity
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-hydroxyacyl-CoA reductase activity
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetyl coenzyme A reductase activity
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-3-hydroxyacyl-CoA dehydrogenase activity
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP-linked acetoacetyl CoA reductase activity
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyacyl coenzyme-A dehydrogenase activity
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-ketoacyl-CoA reductase
GO:0018454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:acetoacetyl-CoA reductase activity
RHEA:71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)
REACT:R-HSA-5655245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
REACT:R-HSA-8853890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX binds the IL6 gene promoter (Homo sapiens)
RHEA:15157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)
GO:0090588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity
RHEA:43249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate
REACT:R-RNO-5635854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI2,3 are degraded by the proteasome (Rattus norvegicus)
REACT:R-DME-73589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => beta-ureidopropionate (Drosophila melanogaster)
REACT:R-CFA-3149519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC decyanates CNCbl (Canis familiaris)
REACT:R-MMU-5362459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Mus musculus)
RHEA:31713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:44069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)
RHEA:54237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycerol + CDP-choline => 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)
GO:0009979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16:0 monogalactosyldiacylglycerol desaturase activity
REACT:R-BTA-350186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN binds GC:25(OH)D (Bos taurus)
RHEA:18464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CEL-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Caenorhabditis elegans)
REACT:R-CEL-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Caenorhabditis elegans)
RHEA:64353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA
GO:0090686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine-activated nonselective monovalent cation channel activity
REACT:R-GGA-2730870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)
REACT:R-HSA-3857305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)
GO:0016624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a disulfide as acceptor"
GO:0016624	skos:prefLabel	"With a disulfide as acceptor"
GO:0016624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0016624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor
REACT:R-GGA-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Gallus gallus)
RHEA:62577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-cystine(out) => ADP + H(+) + L-cystine(in) + phosphate
REACT:R-GGA-4641206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPOs bind LGRs (Gallus gallus)
RHEA:61609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbB protein]-dithiol + a quinone => [DsbB protein]-disulfide + a quinol
RHEA:52047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mogrol + UDP-alpha-D-glucose <=> H(+) + mogroside IE + UDP
REACT:R-RNO-110354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of OGG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
GO:0015660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate efflux transmembrane transporter activity
GO:0015660	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate efflux permease activity
REACT:R-DDI-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)
REACT:R-HSA-9667569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,2 bind AVPR antagonists (Homo sapiens)
REACT:R-DRE-193666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active JNK moves to the nucleus and phosphorylates different transcription factors (Danio rerio)
REACT:R-GGA-189242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Gallus gallus)
REACT:R-MMU-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Mus musculus)
RHEA:23504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylcobinamide hydrolase"
RHEA:23504	skos:altLabel	"AdoCbi hydrolase"
RHEA:23504	skos:prefLabel	"adenosylcobinamide hydrolase"
RHEA:23504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + H2O = (R)-1-aminopropan-2-ol + adenosylcob(III)yrate
RHEA:23504	skos:altLabel	"AdoCbi amidohydrolase"
REACT:R-HSA-8877345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 (Homo sapiens)
REACT:R-CFA-2395872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)
RHEA:68620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + H(+) + NADPH = 20beta-dihydrocortisone + NADP(+)
GO:0033756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity
GO:0033756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oplophorus-luciferin 2-monooxygenase activity
GO:0033756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Oplophorus luciferase activity
REACT:R-BTA-159567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform ST to ST-CoA (Bos taurus)
REACT:R-MMU-2022065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPGs are secreted (Mus musculus)
REACT:R-CFA-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Canis familiaris)
RHEA:31685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-solanapyrone A => prosolanapyrone III
REACT:R-RNO-2168881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Truncated Alpha-1-Microglobulin binds heme (Rattus norvegicus)
RHEA:67736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-neuraminate = aceneuramate
REACT:R-DME-8939688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(SKP2) complex binds RUNX2 (Drosophila melanogaster)
REACT:R-XTR-9733292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMY1-3 bind pramlintide (Xenopus tropicalis)
RHEA:18996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate
RHEA:12772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-gluconate <=> 2-dehydro-D-gluconate + AH2
REACT:R-BTA-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Bos taurus)
REACT:R-XTR-9624845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCC1 stimulates GDP to GTP exchange on RAN (Xenopus tropicalis)
REACT:R-SSC-71397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipo-PDH decarboxylates PYR to Ac-CoA (Sus scrofa)
REACT:R-CFA-8948015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Canis familiaris)
RHEA:28217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + prostaglandin H2 <=> [thioredoxin]-disulfide + prostaglandin F2alpha
RHEA:49067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Rattus norvegicus)
REACT:R-DRE-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Danio rerio)
RHEA:55792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-one + H(+) + NADH + O2 = 1-hydroxy-2-butanone + H2O + NAD(+)
RHEA:35412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside => an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)
GO:0050167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pantothenylcysteine decarboxylase activity
GO:0050167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pantothenoylcysteine decarboxylase activity
GO:0050167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)
GO:0050167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity
GO:0050167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity
REACT:R-RNO-4616015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HDAC2 with SUMO1 (Rattus norvegicus)
REACT:R-BTA-76386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 S-demethylates 6MMP (Bos taurus)
REACT:R-XTR-1254376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Xenopus tropicalis)
REACT:R-SSC-75899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Sus scrofa)
RHEA:67348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-beta-D-glucoside + malonyl-CoA = apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA
RHEA:34083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-3-hydroxyacyl-CoA = a (3S)-3-hydroxyacyl-CoA
REACT:R-XTR-2453833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE65 isomero-hydrolyses atREs to 11cROL (Xenopus tropicalis)
REACT:R-HSA-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Homo sapiens)
RHEA:37577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-DME-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Drosophila melanogaster)
REACT:R-BTA-211882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A7 can 6beta-hydroxylate testosterone (Bos taurus)
RHEA:42325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) => 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:44356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nogalaviketone = methyl nogalonate
RHEA:44356	skos:altLabel	"methyl nogalonate cyclase"
RHEA:44356	skos:prefLabel	"nogalonic acid methyl ester cyclase"
RHEA:44356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nogalonic acid methyl ester cyclase"
REACT:R-RNO-417896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y6 receptor can bind to UDP (Rattus norvegicus)
REACT:R-RNO-879594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO4C1 mediates the transport of digoxin (Rattus norvegicus)
RHEA:43387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginyl-[protein] <=> ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]
REACT:R-SSC-5682690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 dissociates from ATG12:ATG5 (Sus scrofa)
RHEA:35840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => a cardiolipin + CoA
RHEA:39360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)
RHEA:68684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) = adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)
REACT:R-MMU-6808566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHGA-derived peptide binds the bacterial cell surface (Mus musculus)
RHEA:58652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifamycin SV ortho-naphthoquinone carboxamide = rifamycin SV para-naphthoquinone carboxamide
EC:3.4.21.9	skos:altLabel	"enterokinase"
EC:3.4.21.9	skos:prefLabel	"enteropeptidase"
EC:3.4.21.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enteropeptidase"
REACT:R-CFA-195283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Canis familiaris)
REACT:R-CEL-2028670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Caenorhabditis elegans)
REACT:R-DRE-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Danio rerio)
RHEA:18870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-xylulose => ADP + H(+) + L-xylulose 5-phosphate
REACT:R-SCE-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Saccharomyces cerevisiae)
REACT:R-DRE-6795290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TORC2 complex phosphorylates SGK1 (Danio rerio)
RHEA:69115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-2-aminoadipate <=> 2-oxoadipate + glycine
REACT:R-DRE-170846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 recruits TGFBR1 (Danio rerio)
REACT:R-CEL-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Caenorhabditis elegans)
REACT:R-SSC-6799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates TP53 (Sus scrofa)
RHEA:50970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine(37) in tRNA(Ala) + NH4(+) => adenosine(37) in tRNA(Ala) + H(+) + H2O
RHEA:65799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Xenopus tropicalis)
RHEA:69805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-AMP + diphosphate => ATP + benzoate + H(+)
RHEA:31599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + NADH + O2 + thymine = (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)
RHEA:43082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-8847875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF1:GTP binds Golgin TRIP11 (Sus scrofa)
GO:0034858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzothiazole monooxygenase activity
REACT:R-DME-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Drosophila melanogaster)
GO:0016407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyltransferase activity
GO:0016407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylase activity
GO:0018541	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:p-benzoquinone oxidoreductase activity
GO:0018541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-benzoquinone reductase (NADPH) activity
REACT:R-BTA-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Bos taurus)
REACT:R-XTR-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Xenopus tropicalis)
RHEA:27387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleate + NH4(+) => H2O + maleamate
REACT:R-MMU-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Mus musculus)
REACT:R-SPO-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Schizosaccharomyces pombe)
REACT:R-XTR-6810410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Xenopus tropicalis)
REACT:R-HSA-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Homo sapiens)
RHEA:24181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]
RHEA:22656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine-phosphoethanolamine synthase"
RHEA:22656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ethanolamine + L-serine = CMP + H(+) + L-serine-phosphoethanolamine
RHEA:22656	skos:prefLabel	"serine-phosphoethanolamine synthase"
REACT:R-DME-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Drosophila melanogaster)
RHEA:44486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine
REACT:R-RNO-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Rattus norvegicus)
REACT:R-CFA-177784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)
RHEA:68361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylono-1,4-lactone + O2 => dehydro-L-arabinono-1,4-lactone + H(+) + H2O2
GO:0015244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluconazole transmembrane transporter activity
GO:0015244	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fluconazole transporter activity
REACT:R-HSA-976743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)
REACT:R-CFA-352119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Canis familiaris)
REACT:R-HSA-9731012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 3a tetramerizes (Homo sapiens)
RHEA:55069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-177926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)
RHEA:29750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropanoate(in) <=> 3-phenylpropanoate(out)
RHEA:61483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + a very long-chain fatty acyl-CoA <=> an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)
REACT:R-HSA-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Homo sapiens)
RHEA:28286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Caenorhabditis elegans)
REACT:R-XTR-210273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and NKp44 (Xenopus tropicalis)
REACT:R-HSA-174967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT2 acetylation (Homo sapiens)
RHEA:69308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = phenylacetonitrile + sulfate + sulfur
GO:0001595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin receptor activity
GO:0080012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trihydroxyferuloyl spermidine O-methyltransferase activity
GO:0080012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity
RHEA:58199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[histone] <=> acetate + L-lysyl-[histone]
RHEA:42711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(46) in tRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine
REACT:R-CFA-110250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenoadenine by MPG glycosylase (Canis familiaris)
EC:4.2.2.13	skos:altLabel	"exo-alpha-1,4-glucan lyase"
EC:4.2.2.13	skos:altLabel	"alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase"
EC:4.2.2.13	skos:altLabel	"exo-(1,4)-alpha-D-glucan lyase"
EC:4.2.2.13	skos:altLabel	"alpha-1,4-glucan exo-lyase"
EC:4.2.2.13	skos:prefLabel	"exo-(1->4)-alpha-D-glucan lyase"
EC:4.2.2.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exo-(1->4)-alpha-D-glucan lyase"
EC:4.2.2.13	skos:altLabel	"alpha-1,4-glucan lyase"
REACT:R-SSC-5694410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMED2:TMED10 tetramer binds GPI anchored proteins (Sus scrofa)
REACT:R-RNO-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Rattus norvegicus)
RHEA:48740	skos:prefLabel	"[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase"
RHEA:48740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase"
RHEA:48740	skos:altLabel	"CysO-thiocarboxylate-dependent cysteine synthase"
RHEA:48740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate
REACT:R-GGA-190520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Golgi  transport vesicles with microtubules (Gallus gallus)
REACT:R-CEL-6800315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 binds MST1R (Caenorhabditis elegans)
RHEA:51042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chromopyrrolate + H(+) + NH4(+) => indole-3-pyruvate imine dimer
RHEA:65960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + leukotriene C4(out) = ADP + H(+) + leukotriene C4(in) + phosphate
REACT:R-HSA-5654625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds SHC1 (Homo sapiens)
REACT:R-BTA-5626223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Bos taurus)
REACT:R-XTR-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Xenopus tropicalis)
RHEA:11290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + macarpine => dihydromacarpine + H(+) + O2
REACT:R-DME-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Drosophila melanogaster)
RHEA:29339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + 2 H(+)(in) = (S)-malate(out) + 2 H(+)(out)
REACT:R-BTA-6784324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Bos taurus)
REACT:R-RNO-191108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)
RHEA:25887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + N(2)-succinyl-L-ornithine <=> H(+) + N(2)-succinyl-L-citrulline + phosphate
REACT:R-BTA-9718020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PTGFR agonists (Bos taurus)
REACT:R-MMU-199112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRTAM binds to NECL2 (Mus musculus)
RHEA:13361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-3-phosphate cytidylyltransferase"
RHEA:13361	skos:altLabel	"CDP-glycerol diphosphorylase"
RHEA:13361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + sn-glycerol 3-phosphate = CDP-glycerol + diphosphate
RHEA:13361	skos:altLabel	"CDP-glycerol pyrophosphorylase"
RHEA:13361	skos:prefLabel	"glycerol-3-phosphate cytidylyltransferase"
REACT:R-CFA-428609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type I Na+-coupled phosphate co-transport (Canis familiaris)
REACT:R-SSC-1169406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host proteins (Sus scrofa)
REACT:R-MMU-9759549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Mus musculus)
REACT:R-DME-190413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2c (Drosophila melanogaster)
REACT:R-DRE-4086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO2,3 (Danio rerio)
REACT:R-GGA-421459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uroporphyrinogen I => coproporphyrinogen I + 4 CO2 (Gallus gallus)
RHEA:51824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + octanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)
REACT:R-BTA-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Bos taurus)
REACT:R-HSA-9673761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)
RHEA:55501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-380869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of docked dopamine loaded synaptic vesicle (Drosophila melanogaster)
RHEA:52837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole + NADH + O2 => H2O + indoxyl + NAD(+)
RHEA:35034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine(in) <=> L-serine(out)
RHEA:69768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-enal + H2O + NAD(+) => (E)-non-2-enoate + 2 H(+) + NADH
RHEA:50737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + 2 H(+) + hydrogen sulfide + sulfite => a quinol + thiosulfate
RHEA:53325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin E2
REACT:R-RNO-158747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Rattus norvegicus)
REACT:R-XTR-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)
REACT:R-RNO-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Rattus norvegicus)
REACT:R-DRE-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Danio rerio)
REACT:R-HSA-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Homo sapiens)
RHEA:29534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
REACT:R-XTR-9687828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-GlcNAcylation of RIPK3 (TLR4 signaling) (Xenopus tropicalis)
RHEA:48523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol
REACT:R-XTR-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Xenopus tropicalis)
REACT:R-MMU-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Mus musculus)
REACT:R-SSC-1981128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Sus scrofa)
REACT:R-HSA-9035966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GGT1 does not hydrolyse GSH (Homo sapiens)
REACT:R-DRE-8987255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Danio rerio)
REACT:R-SSC-8942575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Sus scrofa)
REACT:R-DME-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Drosophila melanogaster)
REACT:R-HSA-9674546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 (Homo sapiens)
REACT:R-MMU-162742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)
REACT:R-DME-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Drosophila melanogaster)
REACT:R-SSC-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
REACT:R-CFA-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)
RHEA:65714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-galactose 1-phosphate + GDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + GDP-beta-L-galactose
REACT:R-HSA-8875451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates CBL (Homo sapiens)
REACT:R-DRE-975916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 5 by MGAT5 (Danio rerio)
REACT:R-DME-4719423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO3 (Drosophila melanogaster)
RHEA:68526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate
REACT:R-SSC-5666197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds LIN7B (Sus scrofa)
EC:2.4.-.-	skos:prefLabel	"Glycosyltransferases"
EC:2.4.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Glycosyltransferases"
RHEA:58349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate
RHEA:62739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate
REACT:R-HSA-8851929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Homo sapiens)
REACT:R-DRE-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Danio rerio)
REACT:R-CFA-5362518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Canis familiaris)
REACT:R-RNO-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Rattus norvegicus)
REACT:R-SSC-1237119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is oxidized to MOB (Sus scrofa)
RHEA:23312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sucrose:sucrose fructosyltransferase"
RHEA:23312	skos:altLabel	"SST"
RHEA:23312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 sucrose = 1(F)-beta-D-fructosylsucrose + D-glucose
RHEA:23312	skos:altLabel	"sucrose:sucrose 1-fructosyltransferase"
RHEA:23312	skos:altLabel	"Sucrose:sucrose 1(F)-beta-D-fructosyltransferase"
RHEA:23312	skos:prefLabel	"sucrose:sucrose fructosyltransferase"
RHEA:23312	skos:altLabel	"Sucrose 1(F)-fructosyltransferase"
RHEA:23312	skos:altLabel	"sucrose-sucrose 1-fructosyltransferase"
RHEA:43521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-5-(dihydroxymethyl)furan + O2 => 2,5-dicarboxyfuran + H(+) + H2O2
RHEA:44018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH => 2,6,10,14-tetramethylpentadecanal + H2O + NAD(+)
RHEA:24675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cytidine => ADP + CMP + H(+)
RHEA:56204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)
REACT:R-SSC-5682010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10:ATG12 binds ATG5 (Sus scrofa)
RHEA:24699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol
RHEA:70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine + H2O + O2 => 3-hydroxypyruvate + H2O2 + NH4(+)
REACT:R-DME-4793925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S303,307-HSF1 binds YWHAE (14-3-3) (Drosophila melanogaster)
REACT:R-GGA-168933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of phosphorylated IRF3/IRF7 (Gallus gallus)
RHEA:53802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + ursodeoxycholoyl-CoA => lithocholoyl-CoA + ursodeoxycholate
RHEA:28172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-one + hydrogen cyanide => (2R)-2-hydroxy-2-methylbutanenitrile
GO:0034826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity
RHEA:15139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-L-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)
REACT:R-DDI-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Dictyostelium discoideum)
RHEA:11213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole + O2 => 2-formamidobenzaldehyde
RHEA:65852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-Delta(1)-steroid + H2O = a 1-hydroxy-3-oxo steroid
REACT:R-CFA-5623525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo-carrying vesicles bud from the TGN (Canis familiaris)
REACT:R-GGA-3785684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by CTSG (Gallus gallus)
REACT:R-SSC-2454240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-FCERI gamma subunit (Sus scrofa)
RHEA:69749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-CoA + succinate => (indol-3-yl)acetate + succinyl-CoA
RHEA:13656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose <=> [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose
REACT:R-BTA-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Bos taurus)
REACT:R-BTA-8956050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Bos taurus)
RHEA:29975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine(in) + H(+)(in) = 2'-deoxycytidine(out) + H(+)(out)
REACT:R-MMU-194311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Mus musculus)
REACT:R-HSA-9695845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 mutant dimers:GRB2 bind SOS1 (Homo sapiens)
REACT:R-SSC-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Sus scrofa)
RHEA:34910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdate(in) <=> molybdate(out)
RHEA:46185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + isovalerate => 3-methylbutanoyl-CoA + AMP + diphosphate
RHEA:66847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] <=> asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-9008285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Sus scrofa)
REACT:R-DDI-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Dictyostelium discoideum)
REACT:R-SSC-6783556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIFR:JAKs bind gp130:JAKs:CNTFR (Sus scrofa)
RHEA:68083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O <=> a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)
REACT:R-XTR-8852580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clusterin binds C5b-C7, C8, C9 (Xenopus tropicalis)
RHEA:65108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene C + L-prolyl-[peptidyl-carrier protein] = aculene A + holo-[peptidyl-carrier protein]
REACT:R-DDI-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Dictyostelium discoideum)
REACT:R-BTA-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
REACT:R-CFA-5607731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
REACT:R-DRE-2453876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTR:RBP:atROL binds to STRA6 receptor (Danio rerio)
RHEA:46887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
REACT:R-HSA-3159227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIV Virion Budding (Homo sapiens)
GO:0050205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxamate carbamoyltransferase activity
GO:0050205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxamic transcarbamylase activity
GO:0050205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate:oxamate carbamoyltransferase activity
RHEA:54159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate
REACT:R-XTR-6782628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates STAM2:HGS (Xenopus tropicalis)
REACT:R-RNO-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)
REACT:R-SPO-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)
REACT:R-XTR-111955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)
REACT:R-MMU-2514831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 degradation by MMP14 (Mus musculus)
RHEA:37948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O
REACT:R-CEL-198818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1,3 transports DeHA from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:37289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-alanyl-L-leucine(in) + phosphate => ATP + H2O + L-alanyl-L-leucine(out)
GO:0102073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPC8-trans-2-enoyl-CoA hydratase activity
REACT:R-SSC-2076383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3ST1 sulfates GlcN at C3 in heparan sulfate (Sus scrofa)
RHEA:34547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(II)yrinate + H2O + L-glutamine = ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate
RHEA:11755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylsalicylate + H2O <=> acetate + H(+) + salicylate
RHEA:42845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH => 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide
REACT:R-HSA-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Homo sapiens)
REACT:R-SSC-5655481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1:WDR48 binds monoUb:K164-PCNA (Sus scrofa)
GO:0034007	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LIS
GO:0034007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-linalool synthase activity
GO:0034007	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3S-linalool synthase activity
GO:0034007	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity
REACT:R-BTA-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Bos taurus)
REACT:R-RNO-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Rattus norvegicus)
RHEA:15869	skos:altLabel	"D-amino acid transaminase"
RHEA:15869	skos:prefLabel	"D-amino-acid transaminase"
RHEA:15869	skos:altLabel	"D-alanine aminotransferase"
RHEA:15869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + D-alanine = D-glutamate + pyruvate
RHEA:15869	skos:altLabel	"D-amino acid aminotransferase"
RHEA:15869	skos:altLabel	"D-aspartate aminotransferase"
RHEA:15869	skos:altLabel	"D-aspartic aminotransferase"
RHEA:15869	skos:altLabel	"D-alanine transaminase"
RHEA:15869	skos:altLabel	"D-alanine-D-glutamate transaminase"
RHEA:15869	skos:altLabel	"D-aspartate transaminase"
RHEA:15869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-amino-acid transaminase"
RHEA:64690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-DDI-73599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Dictyostelium discoideum)
REACT:R-DDI-446877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is K63 poly-ubiquitinated (Dictyostelium discoideum)
RHEA:14263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA => (E)-sinapoyl-CoA + D-glucono-1,5-lactone
REACT:R-XTR-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Xenopus tropicalis)
RHEA:21745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine => 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine
REACT:R-RNO-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Rattus norvegicus)
RHEA:34645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + squalene
GO:0004941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta2-adrenergic receptor activity
GO:0004941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta2 adrenoceptor
REACT:R-MMU-374680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 trans-homophilic interaction (Mus musculus)
REACT:R-DME-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Drosophila melanogaster)
RHEA:12709	skos:altLabel	"PtdIns-3-kinase"
RHEA:12709	skos:altLabel	"PI3-kinase"
RHEA:12709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol 3-kinase"
RHEA:12709	skos:altLabel	"type III phosphoinositide 3-kinase"
RHEA:12709	skos:altLabel	"1-phosphatidylinositol 3-kinase"
RHEA:12709	skos:prefLabel	"phosphatidylinositol 3-kinase"
RHEA:12709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)
RHEA:12709	skos:altLabel	"type I phosphatidylinositol kinase"
REACT:R-SSC-70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylglycerolphosphate synthase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylglycerophosphate synthase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGP synthase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylglycerophosphate synthetase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylglycerol phosphate synthase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol phosphate phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerophosphate phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol 3-phosphate phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycerol-3-phosphate phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0008444	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylglycerol phosphate synthetase activity
RHEA:42732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (guanine(527)-N(7))-methyltransferase"
RHEA:42732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:42732	skos:prefLabel	"16S rRNA (guanine(527)-N(7))-methyltransferase"
REACT:R-XTR-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Xenopus tropicalis)
RHEA:36357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine
REACT:R-HSA-445089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of pL1 (Y1176) (Homo sapiens)
REACT:R-HSA-112265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Homo sapiens)
REACT:R-DDI-727768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)
RHEA:35669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O
RHEA:65548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside Fuc-GM1 + H2O = alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base
RHEA:71940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + 3 Na(+)(out) => 2-oxoglutarate(in) + 3 Na(+)(in)
REACT:R-DME-5159250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF7IP binds SETDB1 (Drosophila melanogaster)
REACT:R-MMU-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Mus musculus)
REACT:R-XTR-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Xenopus tropicalis)
RHEA:66314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+) => an alpha-mannosylinositol-1-phosphoceramide + H2O
RHEA:49864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid + 2 a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)
REACT:R-MMU-203567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylation of eNOS (Mus musculus)
RHEA:11793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + propene => 1,2-epoxypropane + H2O + NAD(+)
RHEA:14102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-deoxyhypusine + AH2 + O2 => [eIF5A protein]-hypusine + A + H2O
RHEA:65243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + H2O <=> (11Z)-octadecenoate + CoA + H(+)
REACT:R-GGA-6781905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZRANB1 binds APC (Gallus gallus)
RHEA:38956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine 1-phosphate(in) => an N-acylsphing-4-enine 1-phosphate(out)
RHEA:39383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)
REACT:R-BTA-9613570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Bos taurus)
REACT:R-SPO-5685230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 phosphorylates RAD51 (Schizosaccharomyces pombe)
REACT:R-HSA-9006508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVALB gene expression is repressed by MECP2 (Homo sapiens)
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP glucose pyrophosphorylase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine-diphosphate glucose pyrophosphorylase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose diphosphorylase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG pyrophosphorylase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP:glucose-1-phosphate uridylyltransferase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose-1-phosphate uridylyltransferase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPG phosphorylase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose pyrophosphorylase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose pyrophosphorylase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine 5'-diphosphoglucose pyrophosphorylase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate-D-glucose pyrophosphorylase activity
GO:0003983	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP-glucose-1-phosphate uridylyltransferase activity
REACT:R-CEL-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Caenorhabditis elegans)
RHEA:63871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 <=> (2R,9Z)-2-hydroperoxyoctadecenoate
RHEA:72636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-1-methoxyphenazine N(5)-oxide + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine
REACT:R-BTA-76496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Bos taurus)
RHEA:41704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)
REACT:R-HSA-6806647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)
REACT:R-SSC-9700168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates IRS1 (Sus scrofa)
REACT:R-RNO-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Rattus norvegicus)
GO:0015317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate ion carrier activity
GO:0015317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate:hydrogen symporter activity
GO:0015317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate:proton symporter activity
RHEA:25501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate => diphosphate + terpinolene
RHEA:42133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isonocardicin C => nocardicin C
REACT:R-CEL-2130282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)
RHEA:41641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
REACT:R-BTA-4419978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Bos taurus)
RHEA:48134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + phosphate => (2E,6E)-farnesyl phosphate + H2O
REACT:R-HSA-5661161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X:SNCA dissociates (Homo sapiens)
REACT:R-HSA-4719436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)
REACT:R-SSC-8950181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y693-STAT4 dimer translocates to the nucleus (Sus scrofa)
RHEA:34882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + methyl 3-cyano-2-phenylpropanoate <=> 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)
EC:3.1.26.8	skos:altLabel	"5S ribosomal maturation nuclease"
EC:3.1.26.8	skos:prefLabel	"ribonuclease M5"
EC:3.1.26.8	skos:altLabel	"RNase M5"
EC:3.1.26.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease M5"
REACT:R-HSA-6799196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
REACT:R-XTR-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Xenopus tropicalis)
RHEA:66950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA => acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:53776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanylpropanoate + O2 = 3-sulfinopropanoate + H(+)
RHEA:53776	skos:altLabel	"3-sulfanylpropanoate dioxygenase"
RHEA:53776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-mercaptopropionate dioxygenase"
RHEA:53776	skos:altLabel	"3-mercaptopropionic acid dioxygenase"
RHEA:53776	skos:prefLabel	"3-mercaptopropionate dioxygenase"
REACT:R-HSA-420123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like receptor 2 binds GLP2 (Homo sapiens)
REACT:R-SPO-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Schizosaccharomyces pombe)
REACT:R-CFA-5649799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Canis familiaris)
EC:2.6.2.-	skos:prefLabel	"Amidinotransferases"
EC:2.6.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Amidinotransferases"
REACT:R-CFA-5635865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 dissociates from ub-PTCH1 (Canis familiaris)
RHEA:67715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)
RHEA:18004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)
RHEA:70597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA
REACT:R-HSA-201631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 3 (Homo sapiens)
RHEA:15833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxymandelate oxidase (decarboxylating)"
RHEA:15833	skos:prefLabel	"4-hydroxymandelate oxidase (decarboxylating)"
RHEA:15833	skos:altLabel	"4-hydroxymandelate oxidase"
RHEA:15833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxymandelate + H(+) + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2
REACT:R-GGA-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Gallus gallus)
REACT:R-CEL-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Caenorhabditis elegans)
RHEA:44508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-SSC-444859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Sus scrofa)
REACT:R-HSA-390281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Homo sapiens)
RHEA:70103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + o-quinone methide + penilactone D = penilactone B
REACT:R-HSA-182198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
RHEA:69859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in 12S rRNA + S-adenosyl-L-methionine = a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:21053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH
REACT:R-MMU-2855020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Mus musculus)
RHEA:40280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + dodecanoyl-CoA => CoA + O-dodecanoyl-R-carnitine
RHEA:10416	skos:prefLabel	"benzylsuccinate synthase"
RHEA:10416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzylsuccinate synthase"
RHEA:10416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + toluene = 2-benzylsuccinate
REACT:R-HSA-6814695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PERP binds desmosomes (Homo sapiens)
RHEA:30290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 2 a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol
GO:0052734	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DHS reductase activity
GO:0052734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydroshikimic reductase activity
GO:0052734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	shikimate 3-dehydrogenase (NAD+) activity
GO:0052734	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	shikimate oxidoreductase activity
GO:0052734	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	shikimate:NAD(P)(+) oxidoreductase activity
GO:0052734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	shikimate:NAD(P)(+) 3-oxidoreductase activity
GO:0052734	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dehydroshikimic reductase activity
GO:0052734	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-dehydroshikimate reductase activity
REACT:R-DRE-191366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Squalene 2,3-epoxide cyclizes, forming lanosterol (Danio rerio)
REACT:R-DRE-9654521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calmodulin dissociates KRAS4B from the plasma membrane (Danio rerio)
REACT:R-SPO-195664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Schizosaccharomyces pombe)
RHEA:56728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-all-trans-beta-carotene + AH2 + O2 = 4,4-dihydroxy-all-trans-beta-carotene + A + H2O
RHEA:41672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-XTR-193780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Xenopus tropicalis)
REACT:R-HSA-9683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)
REACT:R-DRE-5665751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP:FMNL2 binds Profilin:G-actin (Danio rerio)
GO:0008965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate-protein phosphotransferase activity
GO:0008965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity
GO:0008965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate--protein phosphatase activity
GO:0008965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate sugar phosphotransferase enzyme I activity
GO:0008965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate--protein phosphotransferase activity
GO:0008965	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	enzyme I of the phosphotransferase system
GO:0008965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity
GO:0008965	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sugar--PEP phosphotransferase enzyme I activity
GO:0008965	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate--protein factor phosphotransferase activity
REACT:R-SCE-880007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Saccharomyces cerevisiae)
RHEA:58816	skos:prefLabel	"UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase"
RHEA:58816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase"
RHEA:58816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
RHEA:58816	skos:altLabel	"UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate synthetase"
RHEA:58816	skos:altLabel	"UDP-MurNAc-L-Ala-L-Glu synthetase"
REACT:R-CFA-190265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds to FGF (Canis familiaris)
REACT:R-DME-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Drosophila melanogaster)
REACT:R-MMU-75238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL binds TRAIL receptors (Mus musculus)
RHEA:40967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)
RHEA:71568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphomethyl-dUMP in DNA + L-serine => 5-O-(L-seryl)-dTMP in DNA + phosphate
RHEA:52786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ergothioneine + H2O => 2-sulfenohercynine + AH2 + H(+)
REACT:R-DDI-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Dictyostelium discoideum)
REACT:R-GGA-211206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of DFF to the nucleus (Gallus gallus)
RHEA:60627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine
RHEA:59459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tetradecan-1-ol <=> H(+) + NADPH + tetradecanal
REACT:R-CFA-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Canis familiaris)
RHEA:14573	skos:prefLabel	"glucarate dehydratase"
RHEA:14573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucarate dehydratase"
RHEA:14573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O
RHEA:32313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:23490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone + NADP(+) => 1,4-benzoquinone + H(+) + NADPH
RHEA:20633	skos:prefLabel	"L-ornithine N(alpha)-acyltransferase"
RHEA:20633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-ornithine N(alpha)-acyltransferase"
RHEA:20633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine lipid + H(+) + holo-[ACP]
REACT:R-GGA-9029680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-7 translocates to the nucleus (Gallus gallus)
EC:1.2.1.13	skos:altLabel	"triosephosphate dehydrogenase (NADP(+))"
EC:1.2.1.13	skos:prefLabel	"glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)"
EC:1.2.1.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)"
EC:1.2.1.13	skos:altLabel	"NADP-dependent glyceraldehyde-3-phosphate dehydrogenase"
EC:1.2.1.13	skos:altLabel	"triosephosphate dehydrogenase (NADP+)"
RHEA:41975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) <=> CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)
RHEA:41568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin T + dTDP-2-deoxy-beta-L-fucose = aclacinomycin S + dTDP + H(+)
RHEA:45254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetradecanoate(in) => tetradecanoate(out)
RHEA:43617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-HSA-3240782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1/2/3 stimulates EED transcription (Homo sapiens)
REACT:R-MMU-209859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decarboxylation of 5-hydroxytryptophan forms serotonin (Mus musculus)
REACT:R-HSA-9729481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 N binds to G3BP1,G3BP2 (Homo sapiens)
RHEA:15024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + L-quinate <=> 4-O-feruloyl-D-quinate + CoA
REACT:R-GGA-444620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide S receptor binds neuropeptide S (Gallus gallus)
RHEA:30590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + dimethyl sulfoxide <=> 2-demethylmenaquinone-8 + dimethyl sulfide + H2O
REACT:R-SSC-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Sus scrofa)
RHEA:58744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(7)-methyl-GTP = diphosphate + H(+) + N(7)-methyl-GMP
REACT:R-CFA-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Canis familiaris)
RHEA:22898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH
REACT:R-DRE-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Danio rerio)
GO:1990634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphatase 5 binding
GO:1990634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein phosphatase T binding
REACT:R-DME-183094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)
REACT:R-HSA-8942344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 transports FOLA from extracellular region to cytosol (Homo sapiens)
RHEA:61734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + steviolmonoside + UDP => steviol + UDP-alpha-D-glucose
RHEA:48583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate, water dikinase]-phosphate + H(+) + phosphate <=> [pyruvate, water dikinase] + diphosphate
REACT:R-HSA-6782106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates SNX3, CFTR (Homo sapiens)
REACT:R-XTR-5685604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF6 binds SLAMF6 (Xenopus tropicalis)
REACT:R-HSA-168412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP elicits a NOD2 response (Homo sapiens)
RHEA:57676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] = 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-8874685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds MET (Gallus gallus)
REACT:R-XTR-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Xenopus tropicalis)
REACT:R-RNO-8867041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates EPS15 (Rattus norvegicus)
REACT:R-XTR-450595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR:mRNA complex translocates from the nucleus to the cytosol (Xenopus tropicalis)
REACT:R-XTR-141341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMOX-3 oxidises SPN to SPM (Xenopus tropicalis)
RHEA:30260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a menaquinol + O2 => 2 a menaquinone + 2 H2O
RHEA:31147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylethyleneglycol + NAD(+) = 3,4-dihydroxymandelaldehyde + H(+) + NADH
REACT:R-DRE-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Danio rerio)
REACT:R-DRE-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Danio rerio)
REACT:R-HSA-8985627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 and RB1 bind the COL1A1 gene promoter (Homo sapiens)
REACT:R-HSA-451310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Edited Kainate receptors (Homo sapiens)
REACT:R-DME-8853965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Drosophila melanogaster)
REACT:R-GGA-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Gallus gallus)
REACT:R-RNO-2395320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 binds integrins (Rattus norvegicus)
RHEA:61494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+) => a sphingoid base + an ultra-long-chain fatty acyl-CoA
REACT:R-PFA-5655892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)
RHEA:39656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O
REACT:R-DRE-3240957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of PRC2-EZH2 complex (Danio rerio)
REACT:R-GGA-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Gallus gallus)
REACT:R-SSC-3214912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate MeK5-histone H3 (Sus scrofa)
REACT:R-CFA-5653878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Canis familiaris)
REACT:R-DDI-3215385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Dictyostelium discoideum)
EC:4.1.2.21	skos:prefLabel	"2-dehydro-3-deoxy-6-phosphogalactonate aldolase"
EC:4.1.2.21	skos:altLabel	"6-phospho-2-dehydro-3-deoxygalactonate aldolase"
EC:4.1.2.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-6-phosphogalactonate aldolase"
EC:4.1.2.21	skos:altLabel	"6-phospho-2-keto-3-deoxygalactonate aldolase"
EC:4.1.2.21	skos:altLabel	"2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase"
EC:4.1.2.21	skos:altLabel	"2-oxo-3-deoxygalactonate 6-phosphate aldolase"
EC:4.1.2.21	skos:altLabel	"2-dehydro-3-deoxyphosphogalactonate aldolase"
RHEA:11806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic carboxylate + 2 H(+) + NADH => an aromatic aldehyde + H2O + NAD(+)
REACT:R-RNO-114560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adhesion of integrin alphaIIbbeta3 to fibrin network (Rattus norvegicus)
REACT:R-GGA-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Gallus gallus)
REACT:R-RNO-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Rattus norvegicus)
RHEA:11110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate
RHEA:57991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP
RHEA:44792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-12 + S-adenosyl-L-methionine = H(+) + menaquinol-12 + S-adenosyl-L-homocysteine
RHEA:63205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanoyl-[ACP] => H(+) + holo-[ACP] + octadecanoate
REACT:R-MMU-8951486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C4b (Mus musculus)
EC:3.1.14.1	skos:prefLabel	"yeast ribonuclease"
EC:3.1.14.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"yeast ribonuclease"
RHEA:51889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) => 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH
REACT:R-BTA-5687675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates remaining SSBs in MMEJ (Bos taurus)
RHEA:33554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + H2O <=> a fatty acid + sphinganine
REACT:R-CFA-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)
REACT:R-MMU-211959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A43 6b-hydroxylates TEST (Mus musculus)
RHEA:67019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]
GO:0031747	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2 cysteinyl leukotriene receptor ligand
GO:0031747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2 cysteinyl leukotriene receptor binding
REACT:R-HSA-2179415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Homo sapiens)
REACT:R-RNO-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Rattus norvegicus)
REACT:R-XTR-389941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP-1 and SHP-2 bind pBTLA (Xenopus tropicalis)
RHEA:49360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',2'-dihydroxy-2-oxospirilloxanthin = 2,2'-dioxospirilloxanthin + H2O
REACT:R-BTA-416690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4A binds to PLXND1 (Bos taurus)
REACT:R-MMU-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Mus musculus)
REACT:R-DDI-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Dictyostelium discoideum)
REACT:R-SPO-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)
REACT:R-CFA-8937419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBR3 reduces DOX to DOXOL (Canis familiaris)
RHEA:70748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
GO:0018637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-naphthoate hydroxylase activity
RHEA:58173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => beta-pinacene + diphosphate
REACT:R-GGA-2029475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of AA by iPLA2 upon FCGR activation (Gallus gallus)
EC:3.4.22.3	skos:prefLabel	"ficain"
EC:3.4.22.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ficain"
EC:3.4.22.3	skos:altLabel	"ficin"
REACT:R-DME-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Drosophila melanogaster)
REACT:R-SSC-2162002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Sus scrofa)
REACT:R-MMU-166245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Mus musculus)
RHEA:33530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol <=> CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate
REACT:R-GGA-349593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with Fibronectin (Gallus gallus)
REACT:R-HSA-6798299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates E2F7 expression (Homo sapiens)
REACT:R-GGA-5620914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARF4:GTP binds VxPx-motifs of membrane proteins (Gallus gallus)
REACT:R-HSA-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Homo sapiens)
RHEA:12330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate => [(1->3)-alpha-D-glucosyl](n) + phosphate
REACT:R-DRE-5618080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Danio rerio)
EC:4.1.2.27	skos:altLabel	"sphingosine-1-phosphate aldolase"
EC:4.1.2.27	skos:altLabel	"sphingosine-1-phosphate lyase"
EC:4.1.2.27	skos:prefLabel	"sphinganine-1-phosphate aldolase"
EC:4.1.2.27	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphinganine-1-phosphate aldolase"
EC:4.1.2.27	skos:altLabel	"sphinganine-1-phosphate palmitaldehyde-lyase"
REACT:R-CFA-182969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)
REACT:R-CEL-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Caenorhabditis elegans)
REACT:R-SSC-1855159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Sus scrofa)
RHEA:54494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-DRE-391375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Danio rerio)
REACT:R-XTR-8871370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Xenopus tropicalis)
RHEA:41544	skos:prefLabel	"8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)-tetracenomycin-C 3'-O-methyltransferase"
RHEA:41544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine
RHEA:41544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)-tetracenomycin-C 3'-O-methyltransferase"
REACT:R-BTA-4086200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dentin matrix protein 1 binds integrin alphaVbeta3 (Bos taurus)
REACT:R-DDI-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Dictyostelium discoideum)
RHEA:44048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
REACT:R-HSA-8950314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of calponin-2 (Homo sapiens)
REACT:R-DRE-199443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Danio rerio)
RHEA:69316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate = allyl thiocyanate + sulfate
REACT:R-CFA-380949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK is dephosphorylated (Canis familiaris)
REACT:R-BTA-5229132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 binds APP (Bos taurus)
REACT:R-XTR-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)
REACT:R-HSA-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Homo sapiens)
REACT:R-SSC-264976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Sus scrofa)
REACT:R-SSC-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Sus scrofa)
RHEA:71944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + 3 Na(+)(out) => (S)-malate(in) + 3 Na(+)(in)
RHEA:60229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate
REACT:R-HSA-174808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)
REACT:R-BTA-4420153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds PLCG1 (Bos taurus)
REACT:R-BTA-419490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ATP to P2X receptors (Bos taurus)
REACT:R-GGA-373015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Gallus gallus)
RHEA:52670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate
RHEA:40135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + H2O = (9Z)-tetradecenoate + CoA + H(+)
REACT:R-HSA-9768945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 stimulates FOS gene expression (Homo sapiens)
REACT:R-MMU-211207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fragments of DFF45 dissociate from  DFF40 (Mus musculus)
RHEA:17782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-methionine => formate + L-methionine
GO:0050825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ice crystal binding
GO:0050825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	antifreeze activity
GO:0050825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ice nucleation inhibitor activity
GO:0050825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ice nucleation activity
GO:0050825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ice binding
REACT:R-SCE-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Saccharomyces cerevisiae)
RHEA:10126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzyl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetone
RHEA:64617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferol + acetyl-CoA => (E)-coniferyl acetate + CoA
RHEA:21549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetate + L-lysyl-[alpha-tubulin]
RHEA:72665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O
REACT:R-SSC-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Sus scrofa)
RHEA:60760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone = CoA + jasmolin II
RHEA:25764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-methylmalate + NAD(+) => 3-carboxy-2-oxobutanoate + H(+) + NADH
REACT:R-BTA-5687360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLL or POLM extends aligned DNA DSB ends to fill gaps (Bos taurus)
REACT:R-GGA-2731074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Gallus gallus)
REACT:R-BTA-183072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR non-clathrin mediated endocytosis (Bos taurus)
REACT:R-SPO-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Schizosaccharomyces pombe)
RHEA:40751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate
REACT:R-XTR-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Xenopus tropicalis)
RHEA:10103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sterol ester + H2O <=> a fatty acid + a sterol + H(+)
REACT:R-DME-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Drosophila melanogaster)
REACT:R-RNO-4546386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO1 (Rattus norvegicus)
REACT:R-SCE-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Saccharomyces cerevisiae)
REACT:R-SSC-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Sus scrofa)
REACT:R-RNO-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Rattus norvegicus)
RHEA:54380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = 5-hydroxy-alpha-gurjunene + diphosphate
RHEA:54380	skos:prefLabel	"5-hydroxy-alpha-gurjunene synthase"
RHEA:54380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-hydroxy-alpha-gurjunene synthase"
REACT:R-XTR-5672958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from KSR1:MARK3 (Xenopus tropicalis)
REACT:R-SSC-5693390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B11 dehydrogenates EST17b to E1 (Sus scrofa)
RHEA:50540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin A2 = prostaglandin C2
REACT:R-HSA-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Homo sapiens)
GO:0050170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyl-L-glutamine amidohydrolase activity
GO:0050170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-glutaminase activity
GO:0050170	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peptidoglutaminase I activity
GO:0050170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidoglutaminase activity
GO:0050170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptideglutaminase activity
REACT:R-DDI-211991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclophosphamide is 4-hydroxylated by CYP2B6 (Dictyostelium discoideum)
REACT:R-PFA-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Plasmodium falciparum)
REACT:R-GGA-8987120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IFNLR1 (Gallus gallus)
RHEA:32244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,5-bisphosphate => D-ribulose 1,5-bisphosphate
GO:0032184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO polymer binding
GO:0032184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Smt3 polymer binding
REACT:R-MMU-507719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62:MEKK3 binds to TRAF6 (Mus musculus)
REACT:R-PFA-5263614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)
REACT:R-SPO-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Schizosaccharomyces pombe)
RHEA:60577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] => Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M
REACT:R-GGA-8854899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Gallus gallus)
REACT:R-SSC-3828025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCN (decorin) degradation by MMP14 (Sus scrofa)
GO:0047336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyldeoxycytidine-5'-phosphate kinase activity
GO:0047336	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity
RHEA:42226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + androst-4-ene-3,17-dione => A + testosterone
REACT:R-MMU-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Mus musculus)
RHEA:15932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 H2O + methylenediurea <=> CO2 + N-(hydroxymethyl)urea + 2 NH4(+)
REACT:R-RNO-9707523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to BACH1:MAFK (Rattus norvegicus)
RHEA:44036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12,13-epoxy-(9Z)-octadecenoate + H2O = 12,13-dihydroxy-(9Z)-octadecenoate
RHEA:30281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]
EC:1.14.18.1	skos:altLabel	"monophenol monooxygenase"
EC:1.14.18.1	skos:altLabel	"N-acetyl-6-hydroxytryptophan oxidase"
EC:1.14.18.1	skos:altLabel	"monophenol oxidase"
EC:1.14.18.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosinase"
EC:1.14.18.1	skos:prefLabel	"tyrosinase"
EC:1.14.18.1	skos:altLabel	"tyrosine-dopa oxidase"
EC:1.14.18.1	skos:altLabel	"cresolase"
EC:1.14.18.1	skos:altLabel	"phenolase"
RHEA:47309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Danio rerio)
RHEA:72115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in)
RHEA:52031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonyl-L-amino acid + H2O <=> a jasmonate + an L-alpha-amino acid
RHEA:33874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + H2O <=> glyoxylate + NH4(+) + urea
REACT:R-CEL-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Caenorhabditis elegans)
RHEA:43092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:43092	skos:prefLabel	"23S rRNA (uridine(2479)-2'-O)-methyltransferase"
RHEA:43092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (uridine(2479)-2'-O)-methyltransferase"
RHEA:56805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]
REACT:R-HSA-5333607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSSeH combines with bGalNAc derivative to form GSSebGalNac (Homo sapiens)
REACT:R-HSA-166544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TrkA receptor autophosphorylates (Homo sapiens)
REACT:R-BTA-9693250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the Golgi membrane (Bos taurus)
REACT:R-RNO-5358579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase delta polymerizes DNA across single stranded gap (Rattus norvegicus)
RHEA:49841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid + 2 a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)
REACT:R-RNO-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Rattus norvegicus)
REACT:R-CFA-5682858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate H2AFX (Canis familiaris)
RHEA:23193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:24763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-dopa + NADH <=> 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)
REACT:R-HSA-167014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-beta-NGF homodimer transits to the golgi apparatus (Homo sapiens)
REACT:R-HSA-2130500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of MHC II:Ii complex in to the plasma membrane (Homo sapiens)
REACT:R-BTA-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Bos taurus)
REACT:R-DME-1592240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NRF2 (Drosophila melanogaster)
REACT:R-XTR-163756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of fatty acid synthase (FAS) dimer (Xenopus tropicalis)
RHEA:16151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + diphosphate
REACT:R-PFA-5618073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Plasmodium falciparum)
REACT:R-CFA-9680865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4, CYP2B6 bind ritonavir (Canis familiaris)
REACT:R-MMU-9026911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Mus musculus)
REACT:R-BTA-9606151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)
REACT:R-BTA-6782628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates STAM2:HGS (Bos taurus)
REACT:R-MMU-8851494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase7 hydrolyzes nucleoside triphosphates (Mus musculus)
RHEA:65660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + calciol + H2O = AH2 + calcidiol
REACT:R-HSA-167477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive HIV-1 initiation after formation of the first phosphodiester bond (Homo sapiens)
REACT:R-BTA-163733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of FAS monomer gene by ChREBP:MLX (Bos taurus)
REACT:R-SSC-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Sus scrofa)
REACT:R-SPO-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)
REACT:R-GGA-373887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate + H+ [extracellular] <=> lactate + H+ [cytosol] (Gallus gallus)
REACT:R-HSA-8948602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-19a microRNA binds CNOT6L mRNA (Homo sapiens)
REACT:R-DRE-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Danio rerio)
REACT:R-HSA-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Homo sapiens)
REACT:R-CFA-9731590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)
RHEA:34671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine
RHEA:65074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dauca-4,7-diene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:47646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine
REACT:R-HSA-2012082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR3 cysteine mutants (Homo sapiens)
RHEA:32535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate
RHEA:32535	skos:prefLabel	"2-hydroxyhexa-2,4-dienoate hydratase"
RHEA:32535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyhexa-2,4-dienoate hydratase"
RHEA:42280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate
GO:0015121	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	PPT
GO:0015121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate/phosphate translocator
GO:0015121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate:phosphate antiporter activity
REACT:R-GGA-83793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Gallus gallus)
REACT:R-CFA-3371359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Canis familiaris)
REACT:R-HSA-9712083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK mutants bind PI3KCA (Homo sapiens)
GO:0052613	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-ring carotenoid 3-hydroxylase activity
GO:0052613	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carotene beta-ring hydroxylase activity
GO:0052613	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-carotene hydroxylase activity
GO:0052613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	canthaxanthin 3-hydroxylase activity
RHEA:33884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-scyllo-inosamine + NAD(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH
REACT:R-RNO-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Rattus norvegicus)
RHEA:12443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-saccharopine + NAD(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADH
REACT:R-RNO-211959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A43 6b-hydroxylates TEST (Rattus norvegicus)
REACT:R-RNO-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Rattus norvegicus)
REACT:R-HSA-1247842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
RHEA:68643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> diphosphate + limonene
RHEA:65880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-5alpha-androstan-3,17-dione + A = 5alpha-androstan-1,3,17-trione + AH2
RHEA:65669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine
REACT:R-RNO-688985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63 polyubiquitinated RIP2 associates with the TAK1 complex (Rattus norvegicus)
RHEA:71817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5'-triiodo-L-thyronine(in) => 3,3',5'-triiodo-L-thyronine(out)
RHEA:60427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + valerianol
RHEA:12217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-fluoren-9-ol + NAD(+) => 9H-fluoren-9-one + H(+) + NADH
GO:0008980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionate kinase activity
GO:0008980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:propanoate phosphotransferase activity
GO:0008980	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PduW
GO:0008980	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TdcD
GO:0008980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanoate kinase activity
REACT:R-DRE-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Danio rerio)
GO:0047370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	itaconate CoA-transferase activity
GO:0047370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citramalate coenzyme A-transferase activity
GO:0047370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl coenzyme A-citramalyl coenzyme A transferase activity
GO:0047370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate-citramalate CoA-transferase activity
GO:0047370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl-CoA:citramalate CoA-transferase activity
RHEA:37304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-asparagine(out) + H2O => ADP + glycyl-L-asparagine(in) + H(+) + phosphate
REACT:R-DRE-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Danio rerio)
REACT:R-SSC-192178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)
REACT:R-SCE-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Saccharomyces cerevisiae)
RHEA:41701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)
REACT:R-HSA-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)
REACT:R-CEL-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Caenorhabditis elegans)
RHEA:61999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + lactoyl-CoA <=> CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]
REACT:R-BTA-9020256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Bos taurus)
REACT:R-RNO-421416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proglucagon translocates from the ER Lumen to secretory granules (Rattus norvegicus)
REACT:R-HSA-2424477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)
REACT:R-RNO-1638803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)
RHEA:34885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + selenate(in) => ATP + H2O + selenate(out)
EC:3.4.21.110	skos:prefLabel	"C5a peptidase"
EC:3.4.21.110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"C5a peptidase"
EC:3.4.21.110	skos:altLabel	"streptococcal C5a peptidase"
EC:3.4.21.110	skos:altLabel	"SCP"
RHEA:22657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ethanolamine + L-serine => CMP + H(+) + L-serine-phosphoethanolamine
REACT:R-SSC-210292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and TREM1 (Sus scrofa)
REACT:R-CEL-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Caenorhabditis elegans)
RHEA:27626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + D-xylulose 5-phosphate = beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate
REACT:R-HSA-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Homo sapiens)
GO:0003875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
GO:0003875	skos:altLabel	"ADP-ribose-L-arginine cleavage enzyme"
GO:0003875	skos:prefLabel	"[protein ADP-ribosylarginine] hydrolase"
GO:0003875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein ADP-ribosylarginine hydrolase activity
GO:0003875	skos:altLabel	"ADP-ribose-L-arginine cleaving enzyme"
GO:0003875	skos:altLabel	"ADP-ribosylarginine hydrolase"
GO:0003875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-ribose-L-arginine cleaving enzyme activity
GO:0003875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
GO:0003875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPribosylarginine hydrolase activity
GO:0003875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[protein ADP-ribosylarginine] hydrolase"
GO:0003875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-ribosylarginine hydrolase activity
GO:0003875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
GO:0003875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
GO:0003875	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-ribose-L-arginine cleavage enzyme activity
GO:0003875	skos:altLabel	"N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase"
RHEA:68636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = diphosphate + sabinene
REACT:R-HSA-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Homo sapiens)
REACT:R-XTR-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Xenopus tropicalis)
REACT:R-CFA-1971487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHSY3 transfer GalNAc to chondroitin (Canis familiaris)
REACT:R-PFA-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Plasmodium falciparum)
RHEA:63441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GTP + H(+) => 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate
REACT:R-SSC-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Sus scrofa)
RHEA:39591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA = (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O
REACT:R-HSA-5654614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
RHEA:34599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphinganine + NADP(+) = 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH
REACT:R-RNO-9011985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Rattus norvegicus)
REACT:R-RNO-5686072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-3Y-SHC1 dissociates from IGF1R (Rattus norvegicus)
RHEA:65397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dATP + H2O => 8-oxo-dAMP + diphosphate + H(+)
REACT:R-SSC-8862300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYZ binds bacterial peptidoglycan (Sus scrofa)
RHEA:51763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate
REACT:R-RNO-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Rattus norvegicus)
REACT:R-XTR-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)
REACT:R-RNO-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Rattus norvegicus)
REACT:R-MMU-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)
REACT:R-DDI-77094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of cap binding complex (CBC) (Dictyostelium discoideum)
REACT:R-MMU-8849878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSD-95 binds NMDA receptor (Mus musculus)
RHEA:49265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-[(E)-caffeoyl]-shikimate + H2O => (E)-caffeate + H(+) + shikimate
RHEA:66727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + L-phenylalanine <=> H2O + N-[(S)-lactoyl]-L-phenylalanine
REACT:R-BTA-2485182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Bos taurus)
RHEA:16040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + thymidine <=> 2-deoxy-alpha-D-ribose 1-phosphate + thymine
RHEA:13927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-RNO-9618021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXG1 binds FOXO:SMAD complexes (Rattus norvegicus)
RHEA:24739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
RHEA:12742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + H2O => IDP + NH4(+)
RHEA:25654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2
RHEA:64840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethanol + benzoyl-CoA = CoA + phenethyl benzoate
RHEA:14530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + phosphate
RHEA:24423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-terminal N-formyl-L-methionyl-[peptide] <=> formate + N-terminal L-methionyl-[peptide]
REACT:R-MMU-5694427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA3 binds procollagen VII (Mus musculus)
REACT:R-HSA-3640844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)
RHEA:41780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide
REACT:R-RNO-1793207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses C4S/C6S chains (Rattus norvegicus)
REACT:R-HSA-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Homo sapiens)
REACT:R-DDI-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Dictyostelium discoideum)
RHEA:56814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2
REACT:R-CFA-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Canis familiaris)
RHEA:23495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucosamine <=> UDP-alpha-D-galactosamine
REACT:R-HSA-8964525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)
REACT:R-BTA-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Bos taurus)
REACT:R-SSC-158781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Sus scrofa)
REACT:R-RNO-8987129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Rattus norvegicus)
RHEA:54238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-didecanoyl-sn-glycerol + CDP-choline
REACT:R-CEL-8878914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Caenorhabditis elegans)
REACT:R-BTA-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Bos taurus)
REACT:R-HSA-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Homo sapiens)
RHEA:69285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 17beta-hydroxy steroid + NADP(+) => a 17-oxo steroid + H(+) + NADPH
GO:0005313	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glutamate/aspartate:sodium symporter activity
GO:0005313	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-glutamate transporter activity
GO:0005313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate transmembrane transporter activity
GO:0005313	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamate transmembrane transporter activity
GO:0005313	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glutamate/aspartate porter activity
REACT:R-CFA-2471842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XXV ectomain shedding (Canis familiaris)
RHEA:67453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O => 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)
REACT:R-RNO-352158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A10-mediated uptake of aromatic amino acids (Rattus norvegicus)
RHEA:64861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine => (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine
RHEA:18509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + NADH = 2 H2O + NAD(+)
RHEA:18509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADH peroxidase"
RHEA:18509	skos:prefLabel	"NADH peroxidase"
REACT:R-BTA-8941618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
GO:0101005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitinyl hydrolase activity
GO:0101005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Homo sapiens)
GO:0101005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deubiquitinase activity
RHEA:58088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O = (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)
REACT:R-DME-8949659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Drosophila melanogaster)
REACT:R-CFA-5654730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Canis familiaris)
RHEA:32245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 1,5-bisphosphate => alpha-D-ribose 1,5-bisphosphate
RHEA:24558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH => 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+)
REACT:R-SSC-8948709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Sus scrofa)
REACT:R-DRE-9021068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs bind CAVs (Danio rerio)
REACT:R-DME-165026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Drosophila melanogaster)
RHEA:19866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + uroporphyrinogen III => 4 CO2 + coproporphyrinogen III
REACT:R-MMU-8873946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD3 deubiquitinates PTEN (Mus musculus)
REACT:R-HSA-9012597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu (Homo sapiens)
REACT:R-SSC-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Sus scrofa)
RHEA:43075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Canis familiaris)
REACT:R-GGA-9731931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds selective ERAs (Gallus gallus)
RHEA:16580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + ATP + H(+) <=> P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate
REACT:R-MMU-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Mus musculus)
REACT:R-DDI-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Dictyostelium discoideum)
RHEA:71533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine(in) => guanine(out)
RHEA:36278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NADP(+)
RHEA:16382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinitol + NAD(+) => H(+) + L-xylulose + NADH
REACT:R-GGA-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Gallus gallus)
REACT:R-RNO-8932355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades Ub-NFE2L2 (Rattus norvegicus)
REACT:R-HSA-429955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR4-NOT complex deadenylates mRNA (Homo sapiens)
REACT:R-DRE-1363274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p107 (RBL1) by PP2A (Danio rerio)
REACT:R-SPO-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)
REACT:R-XTR-9754129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 inhibitors bind CDK6 (Xenopus tropicalis)
REACT:R-MMU-380930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AMPK binds AMP (Mus musculus)
REACT:R-BTA-8862084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PILRA,PILRB bind CD99 (Bos taurus)
REACT:R-CFA-8851866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds RANBP10 (Canis familiaris)
REACT:R-BTA-74712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of IRS-P from insulin receptor (Bos taurus)
REACT:R-SSC-6792445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPH, I hydrolyse PA to 2-acyl LPA (Sus scrofa)
REACT:R-SCE-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Saccharomyces cerevisiae)
RHEA:23258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate => adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine
REACT:R-HSA-9684241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Spike trimer to assembling virion (Homo sapiens)
GO:0140293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-ribosylglutamate hydrolase activity
REACT:R-BTA-9667952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 is deacetylated by SIRT2 (Bos taurus)
RHEA:13330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxosteroid => a 3-oxo-Delta(1)-steroid + AH2
REACT:R-GGA-8875568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 activates RAP1 (Gallus gallus)
REACT:R-RNO-5672010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 phosphorylates ULK1 (Rattus norvegicus)
GO:0042019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-23 binding
GO:0042019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-23 binding
RHEA:31002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> cucurbitadienol
REACT:R-SCE-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Saccharomyces cerevisiae)
REACT:R-RNO-9011949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Rattus norvegicus)
REACT:R-BTA-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)
REACT:R-CFA-5690991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Canis familiaris)
RHEA:41207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
RHEA:68832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate + H2O = (6Z)-nerolidol + diphosphate
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin-[acetyl-CoA-carboxylase] ligase activity
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HCS
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA carboxylase biotin holoenzyme synthetase activity
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin--[acetyl-CoA carboxylase] synthetase activity
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	biotin-acetyl-CoA carboxylase synthetase
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin--protein ligase activity
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl CoA holocarboxylase synthetase activity
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-acetyl coenzyme A carboxylase synthetase activity
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-acetyl-CoA-carboxylase ligase activity
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin holoenzyme synthetase activity
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin:apocarboxylase ligase activity
GO:0004077	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A holocarboxylase synthetase activity
REACT:R-DRE-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Danio rerio)
REACT:R-XTR-174054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin A:Cdk2 complexes (Xenopus tropicalis)
GO:0102913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminomethylindole N-methyltransferase activity
RHEA:22030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + taxa-4(20),11-dien-5alpha-yl acetate => acetyl-CoA + taxa-4(20),11-dien-5alpha-ol
RHEA:30284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-trans-permethrin + H2O => (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)
RHEA:21600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + benzoyl-CoA = CoA + N-benzoylanthranilate
RHEA:21600	skos:prefLabel	"anthranilate N-benzoyltransferase"
RHEA:21600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthranilate N-benzoyltransferase"
REACT:R-CFA-9038029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	27-hydroxysterol binds ESR1, ESR2 (Canis familiaris)
RHEA:20696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"superoxide dismutase"
RHEA:20696	skos:prefLabel	"superoxide dismutase"
RHEA:20696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 superoxide = H2O2 + O2
REACT:R-SSC-201810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ligand trap binds the ligand BMP2, blocking BMP signalling (Sus scrofa)
RHEA:49509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphinomethylmalate => 2-(phosphinatomethylidene)butanedioate + H2O
RHEA:24399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scytalone <=> 1,3,8-trihydroxynaphthalene + H2O
REACT:R-HSA-5623806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)
RHEA:37077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine
RHEA:29127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + nitrate = a menaquinone + H2O + nitrite
RHEA:37819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-MMU-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
REACT:R-HSA-2032770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1 to the nucleus (Homo sapiens)
REACT:R-SPO-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Schizosaccharomyces pombe)
RHEA:45165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
RHEA:55737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose => [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP
REACT:R-CEL-70479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate (Caenorhabditis elegans)
EC:1.2.1.4	skos:prefLabel	"aldehyde dehydrogenase (NADP(+))"
EC:1.2.1.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldehyde dehydrogenase (NADP(+))"
REACT:R-SPO-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Schizosaccharomyces pombe)
REACT:R-BTA-6787677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUOM isomerises alpha-Fuc to beta-Fuc (Bos taurus)
RHEA:68634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:22097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + RNA(n+1) => a ribonucleoside 5'-diphosphate + RNA(n)
REACT:R-RNO-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Rattus norvegicus)
RHEA:61636	skos:prefLabel	"isophthalate--CoA ligase"
RHEA:61636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isophthalate--CoA ligase"
RHEA:61636	skos:altLabel	"IPCL"
RHEA:61636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + isophthalate = AMP + diphosphate + isophthalyl-CoA
REACT:R-XTR-1676065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Xenopus tropicalis)
REACT:R-RNO-200396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Creatine transport across the plasma membrane (Rattus norvegicus)
REACT:R-DRE-3000434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Danio rerio)
RHEA:60778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A15 + succinate => 2-oxoglutarate + gibberellin A12 + O2
REACT:R-DRE-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Danio rerio)
RHEA:29132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + nitrate => H2O + menaquinone-8 + nitrite
REACT:R-RNO-977602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to MCP, CR1:C4b, C3b (Rattus norvegicus)
RHEA:51172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
RHEA:14314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iodophenol + S-adenosyl-L-methionine => 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-3928595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ARP2/3 and G-actin (Danio rerio)
REACT:R-MMU-76397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Mus musculus)
RHEA:57384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase"
RHEA:57384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA = (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA
RHEA:57384	skos:prefLabel	"(13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase"
REACT:R-CFA-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Canis familiaris)
REACT:R-RNO-1504193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL is degraded by the proteasome (Rattus norvegicus)
REACT:R-XTR-8853789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDNF,NRTN bind RET:GFRA1,GFRA2 (Xenopus tropicalis)
RHEA:22889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-methylmalonyl-CoA => succinyl-CoA
REACT:R-DRE-419981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Danio rerio)
REACT:R-MTU-936590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur transfer to carrier protein (Mycobacterium tuberculosis)
RHEA:30306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:34634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]
RHEA:46532	skos:prefLabel	"linoleoyl-lipid Delta(12) conjugase (11E,13Z-forming)"
RHEA:46532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linoleoyl-lipid Delta(12) conjugase (11E,13Z-forming)"
RHEA:46532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:48232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glutamate-5-semialdehyde N-acetyltransferase"
RHEA:48232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-glutamate 5-semialdehyde = CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde
RHEA:48232	skos:prefLabel	"L-glutamate-5-semialdehyde N-acetyltransferase"
RHEA:30119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-[ACP] + H2O = dodecanoate + H(+) + holo-[ACP]
RHEA:30119	skos:altLabel	"lauryl-[acyl-carrier protein] hydrolase"
RHEA:30119	skos:altLabel	"dodecanoyl-acyl-carrier-protein hydrolase"
RHEA:30119	skos:prefLabel	"dodecanoyl-[acyl-carrier-protein] hydrolase"
RHEA:30119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dodecanoyl-[acyl-carrier-protein] hydrolase"
RHEA:30119	skos:altLabel	"dodecyl-[acyl-carrier protein] hydrolase"
REACT:R-HSA-444661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR2 binds HCAR2 ligands (Homo sapiens)
REACT:R-SSC-8984012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Sus scrofa)
GO:0018700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-N-isopropylacetanilide reductive dehalogenase activity
RHEA:56984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate
REACT:R-BTA-2453855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)
REACT:R-RNO-8852522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1 dimer:MST1R dimer binds MST1R dimer (Rattus norvegicus)
GO:0019977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-21 binding
GO:0019977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-21 binding
RHEA:37074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine
RHEA:36785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine => L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine
REACT:R-CFA-9627078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP9 (Canis familiaris)
REACT:R-SSC-8876191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 GEFs exchange GTP for GDP on RAB9 (Sus scrofa)
RHEA:22178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]
GO:0036435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)
GO:0036435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K48-linked polyubiquitin modification-dependent protein binding
REACT:R-RNO-83803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Rattus norvegicus)
REACT:R-SCE-200424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Saccharomyces cerevisiae)
REACT:R-GGA-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Gallus gallus)
RHEA:57882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose
RHEA:55437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol
REACT:R-HSA-450975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate <=> citrate (Homo sapiens)
REACT:R-DME-727740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)
RHEA:22220	skos:prefLabel	"ent-kaurene synthase"
RHEA:22220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-kaurene synthase"
RHEA:22220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate = diphosphate + ent-kaur-16-ene
RHEA:22220	skos:altLabel	"ent-kaurene synthase B"
RHEA:22220	skos:altLabel	"ent-kaurene synthetase B"
REACT:R-GGA-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Gallus gallus)
REACT:R-BTA-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Bos taurus)
REACT:R-BTA-193763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)
REACT:R-DRE-6805276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates TP53 (Danio rerio)
REACT:R-GGA-9014454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG translocates to the ER membrane (Gallus gallus)
RHEA:31224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-beta-D-glucosyl-2-hydroxycinnamate + H2O => beta-D-glucose + cis-2-coumarate
RHEA:22423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) <=> 2 H(+) + maleylacetate + NADH
RHEA:15154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + UDP-alpha-D-glucose => 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP
RHEA:44439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol
RHEA:46709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] => AMP + H(+) + salicyl-[non-ribosomal peptide synthase]
RHEA:25971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-benzoin + NADP(+) <=> benzil + H(+) + NADPH
REACT:R-HSA-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
RHEA:59412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxosuccinamate + H2O = NH4(+) + oxaloacetate
RHEA:50863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
REACT:R-BTA-5684169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6B binds PTPN6,PTPN11 (Bos taurus)
REACT:R-DME-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Drosophila melanogaster)
REACT:R-BTA-199154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD200 binds to CD200R (Bos taurus)
REACT:R-SPO-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Schizosaccharomyces pombe)
REACT:R-SPO-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Schizosaccharomyces pombe)
REACT:R-CFA-446130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 2 binds Interleukin 1 (Canis familiaris)
RHEA:49410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->2)-beta-D-mannosyl](n) + phosphate
REACT:R-CFA-8948018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Canis familiaris)
RHEA:65350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4,6-dien-24-oyl-CoA + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA
RHEA:44565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-decaprenyl diphosphate => 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate
RHEA:57869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 => (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate
RHEA:29481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epicubenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:50544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin C2 = prostaglandin B2
REACT:R-HSA-9793679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)
REACT:R-RNO-71303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPE dimers isomerise RU5P to XY5P (Rattus norvegicus)
RHEA:33603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-hexacosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)
RHEA:47645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine
RHEA:36423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine
RHEA:61430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-trans-nepetalactone + H(+) + NADH => cis-trans-nepetalactol + NAD(+)
RHEA:17056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> beta-D-fructose 6-phosphate + D-erythrose 4-phosphate
REACT:R-RNO-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
RHEA:46145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5661116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me3K5-histone H3 (Danio rerio)
RHEA:40969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-CFA-5577213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
REACT:R-SSC-193746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Sus scrofa)
RHEA:20937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O
RHEA:32068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxoguanine + H(+) + H2O => NH4(+) + urate
REACT:R-CFA-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Canis familiaris)
REACT:R-SSC-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Sus scrofa)
REACT:R-BTA-975139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Bos taurus)
RHEA:64726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2
RHEA:65295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + butan-2-one + 3 H2O + hydrogencarbonate <=> 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate
RHEA:62119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + iminosuccinate <=> NH4(+) + oxaloacetate
REACT:R-HSA-8943811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)
REACT:R-SSC-399944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by Cdk5 (Sus scrofa)
RHEA:32018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-delta-cadinene + diphosphate
REACT:R-CFA-9679740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA4:ITGB1 binds natalizumab (Canis familiaris)
REACT:R-HSA-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Homo sapiens)
REACT:R-CFA-879377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Canis familiaris)
REACT:R-CFA-201628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at DSVD (85) (Canis familiaris)
RHEA:65061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADPH
REACT:R-DDI-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)
REACT:R-DME-444007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Drosophila melanogaster)
REACT:R-MMU-9710353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds cardiolipin (Mus musculus)
REACT:R-SSC-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Sus scrofa)
RHEA:61340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA
REACT:R-CFA-9700154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds SHC1 (Canis familiaris)
REACT:R-HSA-9664285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)
RHEA:53978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O
REACT:R-MMU-265428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with VCAM1 (Mus musculus)
RHEA:44547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(out) + ATP + H2O <=> a fatty acid(in) + ADP + H(+) + phosphate
REACT:R-HSA-174209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Homo sapiens)
EC:3.5.1.38	skos:altLabel	"L-asparagine/L-glutamine amidohydrolase"
EC:3.5.1.38	skos:altLabel	"glutaminase-asparaginase"
EC:3.5.1.38	skos:prefLabel	"glutamin-(asparagin-)ase"
EC:3.5.1.38	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamin-(asparagin-)ase"
EC:3.5.1.38	skos:altLabel	"L-ASNase/L-GLNase"
REACT:R-GGA-352052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Gallus gallus)
RHEA:46936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = ATP + H(+) + L-2-aminoadipate + NADPH
RHEA:46936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-2-aminoadipate reductase"
RHEA:46936	skos:altLabel	"alpha-aminoadipate reductase"
RHEA:46936	skos:prefLabel	"L-2-aminoadipate reductase"
RHEA:24663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine + NADPH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NADP(+)
RHEA:59637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotriose + O2 => D-xylotriono-1,5-lactone + H2O2
RHEA:33592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinganine
RHEA:10024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
REACT:R-SSC-8853792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET tyrosine phosphorylation (Sus scrofa)
REACT:R-BTA-8964604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Bos taurus)
RHEA:67785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol
EC:3.4.24.82	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADAMTS-4 endopeptidase"
EC:3.4.24.82	skos:altLabel	"aggrecanase-1"
EC:3.4.24.82	skos:prefLabel	"ADAMTS-4 endopeptidase"
REACT:R-DRE-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Danio rerio)
REACT:R-HSA-9026405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Homo sapiens)
REACT:R-SPO-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Schizosaccharomyces pombe)
GO:0047239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymandelonitrile glucosyltransferase activity
GO:0047239	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity
GO:0047239	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity
GO:0047239	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyanohydrin glucosyltransferase activity
RHEA:61705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-serine => AMP + diphosphate + L-seryl-[peptidyl-carrier protein]
RHEA:70409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine => [(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2
REACT:R-DRE-1482635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by LPGAT (Danio rerio)
GO:0042950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicin transmembrane transporter activity
REACT:R-RNO-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Rattus norvegicus)
REACT:R-CFA-266046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Canis familiaris)
RHEA:44847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + eicosanoyl-CoA <=> CoA + O-eicosanoyl-(R)-carnitine
RHEA:46305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-5607720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)
RHEA:38686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sphing-4-enine(in) <=> ADP + H(+) + phosphate + sphing-4-enine(out)
RHEA:48607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)
RHEA:31460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
RHEA:42319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:54393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-RNO-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Rattus norvegicus)
REACT:R-CFA-5246478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOM binds retinoids (Canis familiaris)
RHEA:38268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylfumaryl-CoA => 3-methylfumaryl-CoA
REACT:R-CFA-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)
RHEA:50010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-methylpretetramide + H2O + NADP(+) => 6-methylpretetramide + 2 H(+) + NADPH + O2
REACT:R-RNO-202344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)
GO:0033731	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity
GO:0033731	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pretyrosine dehydrogenase activity
GO:0033731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arogenate dehydrogenase [NAD(P)+] activity
GO:0033731	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arogenic dehydrogenase activity
RHEA:66789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methyl-L-dopa + O2 => (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2
RHEA:65207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA + H2O <=> (R)-3-hydroxybutanoate + CoA + H(+)
REACT:R-GGA-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Gallus gallus)
REACT:R-HSA-5661188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLCO2A1 does not transport PGT substrates from extracellular region to cytosol (Homo sapiens)
REACT:R-CEL-9757686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDL (Caenorhabditis elegans)
REACT:R-DRE-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Danio rerio)
RHEA:16781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)
RHEA:16781	skos:prefLabel	"acyl-CoA hydrolase"
RHEA:16781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA hydrolase"
RHEA:10359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5beta-androstan-17-one + NAD(+) <=> 5beta-androstane-3,17-dione + H(+) + NADH
REACT:R-GGA-2562541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR4-induced ripoptosome assembly (Gallus gallus)
REACT:R-BTA-390674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB1 bind ADR,NAd (Bos taurus)
RHEA:70884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) => H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)
RHEA:17673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin + S-adenosyl-L-methionine = 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:17673	skos:prefLabel	"quercetin 3-O-methyltransferase"
RHEA:17673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quercetin 3-O-methyltransferase"
RHEA:17673	skos:altLabel	"flavonol 3-O-methyltransferase"
REACT:R-GGA-8847883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins stimulate ARF1 GTPase activity (Gallus gallus)
REACT:R-GGA-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Gallus gallus)
REACT:R-DRE-9733969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts dissociate from FABP6 (Danio rerio)
REACT:R-MMU-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
REACT:R-DME-5652195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD oxidizes D-sorbitol to Fru (Drosophila melanogaster)
REACT:R-SPO-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Schizosaccharomyces pombe)
REACT:R-XTR-5688834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds VCP (Xenopus tropicalis)
GO:0022894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intermediate conductance calcium-activated potassium channel activity
GO:0022894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IK calcium-activated potassium channel activity
GO:0022894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IK KCa channels
GO:0022894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intermdiate conductance KCa channels
REACT:R-SSC-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
RHEA:70484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 => a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate
RHEA:70675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Met-enkephalin-Arg-Phe = L-arginyl-L-phenylalanine + Met-enkephalin
REACT:R-MMU-8932633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Mus musculus)
REACT:R-SCE-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Saccharomyces cerevisiae)
REACT:R-MMU-433698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
RHEA:53632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(3S)-(+)-asterisca-2(9),6-diene synthase"
RHEA:53632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (3S)-(+)-asterisca-2(9),6-diene + diphosphate
RHEA:53632	skos:prefLabel	"(3S)-(+)-asterisca-2(9),6-diene synthase"
REACT:R-BTA-9706344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 phosphorylates GRB10 (Bos taurus)
RHEA:33712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-sulfomuconolactone + H2O => 2 H(+) + maleylacetate + sulfite
RHEA:29232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate(in) => cyanate(out)
RHEA:23210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-glutaconyl-CoA + acetate => acetyl-CoA + trans-glutaconate
REACT:R-BTA-4420206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SRC-1 (Bos taurus)
REACT:R-SCE-165766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4G by activated S6K1 (Saccharomyces cerevisiae)
RHEA:53763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholate + deoxycholoyl-CoA <=> allocholoyl-CoA + deoxycholate
REACT:R-BTA-6811431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Bos taurus)
RHEA:65528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + octanoyl-CoA = CoA + hexyl octanoate
RHEA:12805	skos:altLabel	"tetrahydroprotoberberine cis-N-methyltransferase"
RHEA:12805	skos:prefLabel	"(S)-tetrahydroprotoberberine N-methyltransferase"
RHEA:12805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-tetrahydroprotoberberine N-methyltransferase"
RHEA:12805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-canadine + S-adenosyl-L-methionine = (S)-N-methylcanadine + S-adenosyl-L-homocysteine
GO:0050639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxytaxane O-acetyltransferase activity
GO:0050639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity
GO:0050639	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetyl-CoA:taxan-10beta-ol O-acetyltransferase
GO:0050639	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity
REACT:R-BTA-1861789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) (Bos taurus)
GO:0030350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-responsive element binding
GO:0030350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE binding
REACT:R-HSA-5638333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)
RHEA:67324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine = (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine
RHEA:35305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisopentadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisopentadecanoyl-CoA + NADP(+)
REACT:R-HSA-9618725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOX10, EGR2 and NAB proteins bind the GJB1 promoter (Homo sapiens)
REACT:R-CFA-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Canis familiaris)
RHEA:66733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate
RHEA:54650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate
REACT:R-HSA-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Homo sapiens)
RHEA:11731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopentanol + NAD(+) <=> cyclopentanone + H(+) + NADH
REACT:R-GGA-353455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of DNA-PKcs (Gallus gallus)
RHEA:38206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Xenopus tropicalis)
RHEA:53335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol
RHEA:63387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine
REACT:R-RNO-442749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the nucleus (Rattus norvegicus)
RHEA:59201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + docosanoate + H(+) => diphosphate + docosanoyl-AMP
RHEA:64173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-altrarate => galactarate
RHEA:14200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + NH4(+) <=> ADP + H(+) + L-asparagine + phosphate
RHEA:31171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O
REACT:R-MMU-3857329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Mus musculus)
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha,alpha-trehalose phosphate synthase (UDP-forming)
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose 6-phosphate synthetase activity
GO:0003825	skos:altLabel	"UDP-glucose--glucose-phosphate glucosyltransferase"
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transglucosylase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalosephosphate-UDP glucosyl transferase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalosephosphate-UDP glucosyltransferase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha,alpha-trehalose-phosphate synthase (UDP-forming)"
GO:0003825	skos:altLabel	"trehalose phosphate synthetase"
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose-phosphate synthase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity
GO:0003825	skos:altLabel	"trehalose 6-phosphate synthase"
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose-P synthetase activity
GO:0003825	skos:prefLabel	"alpha,alpha-trehalose-phosphate synthase (UDP-forming)"
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose phosphate synthetase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose-phosphate synthetase activity
GO:0003825	skos:altLabel	"trehalosephosphate-UDP glucosyltransferase"
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-glucosephosphate glucosyltransferase activity
GO:0003825	skos:altLabel	"transglucosylase"
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose phosphate synthase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphotrehalose-uridine diphosphate transglucosylase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
GO:0003825	skos:altLabel	"trehalose 6-phosphate synthetase"
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trehalose phosphate-uridine diphosphate glucosyltransferase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose-glucose-phosphate glucosyltransferase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose phosphate glucosyltransferase activity
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose 6-phosphate synthase activity
GO:0003825	skos:altLabel	"trehalose phosphate synthase"
GO:0003825	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-glucose-phosphate glucosyltransferase activity
REACT:R-BTA-9706837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR antagonists (Bos taurus)
REACT:R-MMU-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Mus musculus)
REACT:R-BTA-265427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Bos taurus)
REACT:R-RNO-8848250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD6 binds LCFA-CoA (Rattus norvegicus)
RHEA:40009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalol + diphosphate => (+)-copalyl diphosphate + H2O
REACT:R-MMU-442749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the nucleus (Mus musculus)
REACT:R-HSA-3785704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSB inducing agents induce double strand DNA breaks (Homo sapiens)
RHEA:31984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-8868230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNX9 recruits components of the actin polymerizing machinery (Drosophila melanogaster)
REACT:R-XTR-177922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR dimerization (Xenopus tropicalis)
RHEA:67521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-MMU-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Mus musculus)
REACT:R-MMU-6809680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTM1 (Mus musculus)
RHEA:66096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine
RHEA:15463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)
REACT:R-XTR-3782535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Xenopus tropicalis)
GO:0018121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)-asparagine ADP-ribosyltransferase activity
REACT:R-DME-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Drosophila melanogaster)
REACT:R-SSC-9708533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 translocates from the cytosol to the nucleoplasm (Sus scrofa)
RHEA:20232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + ATP + H(+) <=> 2,3-dihydroxybenzoyl-5'-AMP + diphosphate
REACT:R-DRE-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Danio rerio)
REACT:R-SSC-5654614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)
REACT:R-DRE-3296301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCRL2 binds CCL19 (Danio rerio)
REACT:R-GGA-158251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)
REACT:R-MMU-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Mus musculus)
REACT:R-CFA-844438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 oligomerizes (Canis familiaris)
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 11beta-monooxygenase activity
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 11beta-hydroxylase activity
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 11-beta/18-hydroxylase activity
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	steroid 11beta/18-hydroxylase activity
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome p450 XIB1 activity
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP11B2
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxygenase, steroid 11beta -mono-
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 11-beta-monooxygenase activity
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid 11-beta-hydroxylase activity
GO:0004507	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP11B1
RHEA:50677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-terminal L-asparaginyl-[protein] => N-terminal L-aspartyl-[protein] + NH4(+)
REACT:R-GGA-114254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYCS binds to APAF1 (Gallus gallus)
GO:0050341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine dioxygenase activity
GO:0050341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymine 7-hydroxylase activity
GO:0050341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-hydroxy-methyluracil dioxygenase activity
GO:0050341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)
GO:0050341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymine,2-oxoglutarate dioxygenase activity
GO:0050341	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-hydroxymethyluracil oxygenase activity
REACT:R-CEL-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Caenorhabditis elegans)
REACT:R-MMU-4551604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PARP1 with SUMO1 (Mus musculus)
REACT:R-DRE-450827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Danio rerio)
RHEA:53600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
REACT:R-BTA-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Bos taurus)
REACT:R-SCE-109857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 binds MAPK3 (Saccharomyces cerevisiae)
REACT:R-DDI-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Dictyostelium discoideum)
RHEA:33848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoate
REACT:R-SPO-156913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regeneration of eEF1A:GTP by eEF1B activity (Schizosaccharomyces pombe)
RHEA:50969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA(Ala) + H(+) + H2O => inosine(37) in tRNA(Ala) + NH4(+)
RHEA:33894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chanoclavine-I + NAD(+) <=> chanoclavine-I aldehyde + H(+) + NADH
RHEA:49074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O => dibenzothiophene + 2 FMNH2 + 2 O2
RHEA:40837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O
REACT:R-XTR-8875374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds LRIG1 (Xenopus tropicalis)
REACT:R-SSC-6805126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates TP53 (Sus scrofa)
REACT:R-RNO-139855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X1-mediated entry of Ca++ from plasma (Rattus norvegicus)
RHEA:56248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]
GO:0097216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine tetraphosphate binding
GO:0097216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-ppGpp-3' binding
REACT:R-DME-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Drosophila melanogaster)
REACT:R-RNO-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Rattus norvegicus)
RHEA:41711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)
REACT:R-RNO-5323526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRAT proteins bind GSK3beta (Rattus norvegicus)
RHEA:32045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate
RHEA:40922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)
RHEA:11559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH
REACT:R-BTA-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Bos taurus)
RHEA:72680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)
GO:0047928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity
GO:0047928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity
GO:0047928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin beta-D-glucosyltransferase activity
GO:0047928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity
GO:0047928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin b-glucosyltransferase activity
GO:0047928	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity
RHEA:64524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA = 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]
RHEA:28456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-fructosyl)-L-lysine(out) => N(6)-(D-fructosyl)-L-lysine(in)
REACT:R-MMU-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)
GO:0016290	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	long-chain fatty-acyl-CoA hydrolase activity
GO:0016290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl thioesterase activity
GO:0016290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA hydrolase activity
GO:0016290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmityl-CoA deacylase activity
GO:0016290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl coenzyme A hydrolase activity
GO:0016290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acyl thioesterase I
GO:0016290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmityl thioesterase I
GO:0016290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmityl thioesterase activity
GO:0016290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl-CoA deacylase activity
REACT:R-CEL-4754187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Caenorhabditis elegans)
REACT:R-CFA-430135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds ADAP (Canis familiaris)
RHEA:52762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O
RHEA:72632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) + 3 Li(+)(out) => Ca(2+)(out) + 3 Li(+)(in)
RHEA:38708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol
RHEA:37794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin A + O2 <=> aclacinomycin Y + H2O2
REACT:R-HSA-1564143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type X degradation by MMP1,2 (Homo sapiens)
RHEA:28617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1Z,2S)-2-methylbutanal oxime <=> (2S)-2-methylbutanenitrile + H2O
RHEA:10283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,7-dimethylxanthine + S-adenosyl-L-methionine <=> caffeine + H(+) + S-adenosyl-L-homocysteine
RHEA:57456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP
REACT:R-BTA-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)
REACT:R-DDI-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Dictyostelium discoideum)
REACT:R-SSC-9012374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Sus scrofa)
REACT:R-HSA-163595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acylglycerol + H2O -> glycerol + fatty acid (Homo sapiens)
REACT:R-CFA-5691439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRISC complex deubiquitinates NLRP3 (Canis familiaris)
RHEA:20419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + coelenteramide + hnu => coelenterazine + O2
REACT:R-SSC-166792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C2 into C2a and C2b (Sus scrofa)
REACT:R-RNO-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Rattus norvegicus)
REACT:R-SPO-425822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K+-independent Li+/Ca2+ exchanger transport (Schizosaccharomyces pombe)
REACT:R-DRE-947531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Danio rerio)
REACT:R-BTA-68954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm2-7 is phosphorylated by DDK (Bos taurus)
REACT:R-XTR-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Xenopus tropicalis)
RHEA:51477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + formate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O
REACT:R-SSC-9008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylation (Sus scrofa)
RHEA:48474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1a + N-acetylneuraminate => ganglioside GT1a + H2O
REACT:R-HSA-4518575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-92b binds 3'UTR of NLK mRNA (Homo sapiens)
REACT:R-RNO-8956184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Rattus norvegicus)
RHEA:44246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol
REACT:R-SSC-1433423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP-RO interacts with p-c-Kit complex (Sus scrofa)
RHEA:63225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol
RHEA:38195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-9727607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ binds sacubitrilat (Mus musculus)
REACT:R-GGA-174425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Gallus gallus)
REACT:R-MMU-6806831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5Rs reduce MetHb to HbA (Mus musculus)
RHEA:64382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2 => 3 A + phytyl diphosphate
REACT:R-HSA-2162096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir diphosphate + ATP => carbovir triphosphate + ADP (Homo sapiens)
REACT:R-CFA-420489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parathyroid hormone receptor can bind parathyroid hormone (Canis familiaris)
RHEA:18332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,3R,5S)-sabinol + NAD(+) <=> (1S,5S)-sabinone + H(+) + NADH
RHEA:55750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-MMU-9706399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 hydrolyzes ATP (Mus musculus)
RHEA:69708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O => beta-D-galactose + N-hexadecanoylsphinganine
REACT:R-HSA-8849882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-4 bind reticulon 3 (Homo sapiens)
REACT:R-CEL-430308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARVB interacts with Alpha-actinin (Caenorhabditis elegans)
RHEA:31159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH
REACT:R-DME-1482961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Drosophila melanogaster)
RHEA:15557	skos:altLabel	"nickel-transporting ATPase"
RHEA:15557	skos:altLabel	"nickel ABC transporter"
RHEA:15557	skos:prefLabel	"ABC-type Ni(2+) transporter"
RHEA:15557	skos:altLabel	"ABC-type nickel-transporter"
RHEA:15557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type Ni(2+) transporter"
RHEA:15557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate
REACT:R-RNO-6807214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Rattus norvegicus)
REACT:R-SCE-1482976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-DAG is converted to PI by CDIPT (Saccharomyces cerevisiae)
REACT:R-GGA-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Gallus gallus)
REACT:R-MMU-8855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR binds DAB1 (Mus musculus)
REACT:R-DRE-3322001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)
REACT:R-CEL-8981534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin dimer:KIRREL binds FYN (Caenorhabditis elegans)
RHEA:14624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> lanosterol
REACT:R-MMU-5687360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLL or POLM extends aligned DNA DSB ends to fill gaps (Mus musculus)
RHEA:48826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer
REACT:R-MMU-8874082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates PTK2 (Mus musculus)
RHEA:67696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanedioyl-CoA = CoA + H(+) + hexadecanedioate
REACT:R-DME-5654673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Drosophila melanogaster)
REACT:R-BTA-6782224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)
REACT:R-RNO-9650165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC trimers bind H+ (Rattus norvegicus)
RHEA:34100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxynorspermidine + H(+) => CO2 + norspermidine
REACT:R-XTR-6804379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds TTC5 (Xenopus tropicalis)
REACT:R-HSA-9610750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Homo sapiens)
GO:0052900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermine oxidase (propane-1,3-diamine-forming) activity
GO:0052900	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polyamine oxidase (propane-1,3-diamine-forming) activity
REACT:R-DDI-70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine => urocanate + NH4+ (Dictyostelium discoideum)
REACT:R-XTR-8858346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMHR2 binds AMH (Xenopus tropicalis)
REACT:R-BTA-5205663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)
REACT:R-MMU-2167942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII ectodomain shedding (Mus musculus)
GO:1901239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(1-) transmembrane transporter activity
GO:1901239	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonic acid uptake transmembrane transporter activity
GO:1901239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate(in) = malonate(out)
RHEA:61733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steviol + UDP-alpha-D-glucose => H(+) + steviolmonoside + UDP
REACT:R-XTR-429992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARN deadenylates mRNA (Xenopus tropicalis)
RHEA:61658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl phosphate + ADP + H(+) => (2E,6E)-farnesol + ATP
RHEA:57546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-5624473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Sus scrofa)
RHEA:49182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine => a bacteriochlorophyllide d + S-adenosyl-L-methionine
RHEA:20843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-histidine <=> CO2 + histamine
RHEA:60988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hex-2-en-1-ol + NAD(+) = (E)-hex-2-enal + H(+) + NADH
REACT:R-GGA-216069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaDbeta2 with fibrin (Gallus gallus)
RHEA:41053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA
RHEA:39525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA
REACT:R-GGA-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Gallus gallus)
RHEA:17887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylene + H2O => acetaldehyde
RHEA:64138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-asparagine => H2O + N-(9Z-octadecenoyl)-L-asparagine
REACT:R-GGA-188979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of linear starch (amylose) by extracellular amylase (Gallus gallus)
REACT:R-HSA-5684008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBN binds KPNA2 (Homo sapiens)
RHEA:49577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + GTP + S-adenosyl-L-methionine => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine
RHEA:30923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)
RHEA:30923	skos:prefLabel	"glucosylglycerate synthase"
RHEA:30923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosylglycerate synthase"
REACT:R-DRE-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Danio rerio)
REACT:R-CFA-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)
REACT:R-MMU-4086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO2,3 (Mus musculus)
RHEA:23176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetate--CoA ligase"
RHEA:23176	skos:altLabel	"acetyl-CoA synthetase"
RHEA:23176	skos:prefLabel	"acetate--CoA ligase"
RHEA:23176	skos:altLabel	"acetate thiokinase"
RHEA:23176	skos:altLabel	"Acetyl-activating enzyme"
RHEA:23176	skos:altLabel	"acyl-activating enzyme"
RHEA:23176	skos:altLabel	"Acetyl-CoA synthase"
RHEA:23176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate
REACT:R-SSC-6787677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUOM isomerises alpha-Fuc to beta-Fuc (Sus scrofa)
RHEA:71834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + creatine(out) + 2 Na(+)(out) <=> chloride(in) + creatine(in) + 2 Na(+)(in)
REACT:R-HSA-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Homo sapiens)
REACT:R-RNO-209840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two DITs combine to form thyroxine (Rattus norvegicus)
RHEA:43856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)
REACT:R-MMU-9757954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N4BP1 binds IKBKG (Mus musculus)
REACT:R-GGA-169904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3G stimulates nucleotide exchange on Rap1 (Gallus gallus)
REACT:R-CEL-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Caenorhabditis elegans)
REACT:R-DRE-443439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-Src binds Raf1 (Danio rerio)
GO:0016807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type carboxypeptidase activity
RHEA:10245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-fumarylacetoacetate + H2O => acetoacetate + fumarate + H(+)
REACT:R-CFA-6805205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR35 binds kynurenic acid (Canis familiaris)
RHEA:26348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactonate + NADP(+) <=> aldehydo-D-galacturonate + H(+) + NADPH
RHEA:69204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate
REACT:R-HSA-9709268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective BRCA2 does not translocate to the nucleus (Homo sapiens)
REACT:R-CFA-6811508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ING2-bound EP300 acetylates TP53 (Canis familiaris)
RHEA:24498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + vindoline => 4-O-deacetylvindoline + acetyl-CoA
RHEA:15018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phosphate monoester + H2O => an alcohol + phosphate
RHEA:19332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuatigenin + UDP-alpha-D-glucose <=> H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP
GO:0008566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled mitochondrial protein transporter activity
GO:0008566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mitochondrial protein-transporting ATPase activity
REACT:R-DME-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Drosophila melanogaster)
REACT:R-DRE-8957389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Danio rerio)
RHEA:25411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + D-glucose <=> ADP + alpha,alpha-trehalose + H(+)
REACT:R-HSA-5655278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 mutants phosphorylate FRS2 (Homo sapiens)
REACT:R-XTR-8955285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)
REACT:R-MMU-5620975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PIPs (Mus musculus)
REACT:R-HSA-9613352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLINs bind HSPA8 (Homo sapiens)
RHEA:72652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 => 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)
GO:0009016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyldiaminopimelate transferase activity
GO:0009016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyldiaminopimelate aminotransferase activity
GO:0009016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity
GO:0009016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-succinyl-L-diaminopimelic glutamic transaminase activity
GO:0009016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyldiaminopimelate transaminase activity
REACT:R-DDI-5658438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRED dimer binds NF1 (Dictyostelium discoideum)
RHEA:23026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-beta-D-glucosyl](n) + phosphate
RHEA:20882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-oxodecanoate + H(+) + NADH => 10-hydroxydecanoate + NAD(+)
REACT:R-XTR-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Xenopus tropicalis)
REACT:R-DRE-549241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-HSA-1592250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)
RHEA:69114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + glycine => glyoxylate + L-2-aminoadipate
REACT:R-MMU-4551661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates RNF168 with SUMO1 (Mus musculus)
REACT:R-CEL-8937442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES3 hydrolyses CHEST to CHOL and LCFA(-) (Caenorhabditis elegans)
REACT:R-DME-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Drosophila melanogaster)
RHEA:26531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O
REACT:R-DDI-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Dictyostelium discoideum)
REACT:R-HSA-9712201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAL exchanges GDP for GTP in odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 (Homo sapiens)
RHEA:50243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[hyaluronan](n) <=> n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O
REACT:R-RNO-8854302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D7 binds the TSC1-TSC2 complex (Rattus norvegicus)
REACT:R-BTA-202917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 1 (Bos taurus)
REACT:R-BTA-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Bos taurus)
RHEA:68114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + propanoate => H2O + propanamide
GO:0005141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-10 receptor binding
GO:0005141	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-10 receptor ligand
GO:0005141	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-10
REACT:R-CFA-964800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuromedin-U receptors bind neuromedins U, S (Canis familiaris)
REACT:R-DDI-209845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
GO:0120241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminobutanoate/2-iminopropanoate deaminase
GO:0120241	skos:prefLabel	"2-iminobutanoate/2-iminopropanoate deaminase"
GO:0120241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
GO:0120241	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	2-iminobutanoate deaminase
GO:0120241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminopropanoate + H2O = NH4(+) + pyruvate
GO:0120241	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	imine intermediate deaminase activity
GO:0120241	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	enamine/imine deaminase
GO:0120241	skos:altLabel	"enamine/imine deaminase"
GO:0120241	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	2-iminopropanoate deaminase
GO:0120241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-iminobutanoate/2-iminopropanoate deaminase"
RHEA:24222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:25997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine + O2 => H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine
REACT:R-DME-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Drosophila melanogaster)
GO:0047205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxycinnamoyl coenzyme A-quinate transferase activity
GO:0047205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinate O-hydroxycinnamoyltransferase activity
GO:0047205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity
GO:0016812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
REACT:R-CEL-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Caenorhabditis elegans)
RHEA:62096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-glycerol + phosphate
RHEA:31250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + prop-2-ynal + pyrroloquinoline quinol <=> prop-2-yn-1-ol + pyrroloquinoline quinone
REACT:R-GGA-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Gallus gallus)
REACT:R-CEL-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Caenorhabditis elegans)
RHEA:44765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-6798258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTPRF, PTPRS, PTPRD bind LRRC4B (Rattus norvegicus)
RHEA:42015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + NAD(+) <=> 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH
RHEA:22164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Forssman (d18:1(4E)) + H(+) + UDP
RHEA:22164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"globoside alpha-N-acetylgalactosaminyltransferase"
RHEA:22164	skos:altLabel	"Forssman synthase"
RHEA:22164	skos:prefLabel	"globoside alpha-N-acetylgalactosaminyltransferase"
RHEA:64278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chrysophanol + H2O => chrysophanol-9-anthrone + O2
REACT:R-MMU-2130282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated beta catenin by the proteasome (Mus musculus)
REACT:R-PFA-481009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of platelet dense granule content (Plasmodium falciparum)
REACT:R-MMU-2213243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of COPII vesicle with Golgi complex (Mus musculus)
REACT:R-HSA-381543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP4 binds IGF forming IGF:IGFBP4 (Homo sapiens)
RHEA:11633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-selenocysteine => A + H(+) + hydrogenselenide + L-alanine
REACT:R-DRE-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Danio rerio)
RHEA:45932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:54257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidyl-[protein] + O2 => (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate
REACT:R-DRE-419003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Nectins with Afadin (Danio rerio)
REACT:R-BTA-2424487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
RHEA:54713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
RHEA:68691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) <=> 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CEL-6809680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTM1 (Caenorhabditis elegans)
GO:0046593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mandelonitrile lyase activity
GO:0046593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-oxynitrilase activity
GO:0046593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mandelonitrile benzaldehyde-lyase (cyanide-forming)
GO:0046593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-oxynitrilase activity
GO:0046593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mandelonitrile benzaldehyde-lyase activity
GO:0046593	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxynitrile lyase activity
GO:0046593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-alpha-hydroxynitrile lyase activity
EC:1.1.1.383	skos:prefLabel	"ketol-acid reductoisomerase [NAD(P)(+)]"
EC:1.1.1.383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ketol-acid reductoisomerase [NAD(P)(+)]"
REACT:R-MMU-8865320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX1 (Mus musculus)
RHEA:15299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose
GO:0042164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-12 alpha subunit binding
GO:0042164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-12A binding
GO:0042164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NKSFp35 binding
GO:0042164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLMFp35 binding
GO:0042164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-12p35 binding
REACT:R-DRE-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Danio rerio)
REACT:R-SSC-1433374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processing of SCF isoform 1 (Sus scrofa)
RHEA:55385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate => 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate
REACT:R-HSA-5205652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 recruits Parkin to the outer mitochondrial membrane. (Homo sapiens)
RHEA:44794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-12 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-12 + S-adenosyl-L-methionine
RHEA:27800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-octaprenyl diphosphate + 5 diphosphate => (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate
GO:0099103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	channel gating activity
GO:0099103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	channel activator activity
REACT:R-DME-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Drosophila melanogaster)
RHEA:55158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + S-sulfanylglutathione => a quinone + glutathione + H(+) + hydrogen sulfide
REACT:R-GGA-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Gallus gallus)
REACT:R-XTR-9014294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the plasma membrane (Xenopus tropicalis)
REACT:R-RNO-205234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)
RHEA:70456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2
REACT:R-CFA-8850529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGS proteins bind GNB5 and CCT/TRiC (Canis familiaris)
RHEA:42494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-N-debenzoyltaxol + A + H2O => 3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2
RHEA:32076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate
REACT:R-HSA-8950365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)
RHEA:65469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + acetyl-CoA => CoA + propyl acetate
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carboxylate-terminus binding
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxy-terminus binding
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxyl-terminal binding
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein C-terminus binding
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxyl-terminus binding
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxylate-terminal binding
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal binding
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	COOH-terminus binding
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal end binding
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxy-terminal binding
GO:0008022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	COOH-terminal binding
REACT:R-MMU-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
REACT:R-HSA-158849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phenol can form a sulfate conjugate (Homo sapiens)
REACT:R-HSA-211716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rho GTPase-activating protein 10 (RHG10) interacts with caspase-activated PAK-2p34 (Homo sapiens)
RHEA:39609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH
REACT:R-BTA-114544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p115-RhoGEF activation of RHOA (Bos taurus)
REACT:R-BTA-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Bos taurus)
RHEA:37269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + L-aspartate => H2O + L-alanyl-L-aspartate
REACT:R-GGA-5654684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR4 (Gallus gallus)
RHEA:14920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-6811431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Rattus norvegicus)
RHEA:40507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
RHEA:23603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-2-aminohexanoate <=> 2-oxohexanoate + L-glutamate
RHEA:58732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyl-CTP + H2O = 5-methyl-CMP + diphosphate + H(+)
REACT:R-MMU-1566962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin degradation by elastin-degrading extracellular proteinases (Mus musculus)
REACT:R-MMU-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Mus musculus)
REACT:R-BTA-1236943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigen peptide onto MHC class I molecule (Bos taurus)
RHEA:65770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-XTR-9023860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone acetyltransferases are recruited to the TFF1 gene (Xenopus tropicalis)
REACT:R-DRE-445757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1 receptor antagonist protein binds Interleukin 1 receptors (Danio rerio)
RHEA:57388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57388	skos:prefLabel	"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase"
RHEA:57388	skos:altLabel	"CYP82X1"
RHEA:57388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase"
RHEA:27502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-di-O-methyltricetin + S-adenosyl-L-methionine => 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-9700156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK dimer binds IRS1 (Gallus gallus)
REACT:R-HSA-5668605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2:GTP binds NOX2 complex (Homo sapiens)
REACT:R-SSC-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Sus scrofa)
REACT:R-SSC-156823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Sus scrofa)
REACT:R-DRE-8848110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds activated PTK6 (Danio rerio)
REACT:R-DME-6798747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule membrane proteins (Drosophila melanogaster)
REACT:R-MMU-5691000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIH binds GG-NER site to form a verification complex (Mus musculus)
RHEA:45870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA => 9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA
RHEA:36944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA
RHEA:53997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
RHEA:60465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
RHEA:66658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Cu(2+)(out) + L-ascorbate(in)
RHEA:38894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoylsphing-4-enine <=> hexadecanoate + sphing-4-enine
RHEA:22683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + H(+) + H2O <=> dUTP + NH4(+)
RHEA:70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-bromo-L-tyrosine + NADPH => bromide + L-tyrosine + NADP(+)
GO:0008453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine-glyoxylate aminotransferase activity
GO:0008453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine-glyoxylic aminotransferase activity
GO:0008453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine-glycine transaminase activity
GO:0008453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AGT activity
GO:0008453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanine-glyoxylate transaminase activity
GO:0008453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alanine--glyoxylate aminotransferase activity
GO:0008453	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alanine:glyoxylate aminotransferase activity
REACT:R-DME-9609310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β-blockers bind ADRB1,2,3 (Drosophila melanogaster)
RHEA:48650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:70709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-D-rhamnose => 6-sulfo-beta-D-quinovose
RHEA:39351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA = (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O
REACT:R-XTR-8987104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Xenopus tropicalis)
REACT:R-CEL-8851954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GAB1 recruits PI3K to MET (Caenorhabditis elegans)
RHEA:63389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + Fe(II)-heme o + H2O => 2 AH2 + Fe(II)-heme a
RHEA:29919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)
RHEA:24384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(+) synthase (glutamine-hydrolyzing)"
RHEA:24384	skos:prefLabel	"NAD(+) synthase (glutamine-hydrolyzing)"
RHEA:24384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)
RHEA:24384	skos:altLabel	"nicotinamide adenine dinucleotide synthetase (glutamine)"
RHEA:24384	skos:altLabel	"NAD(+) synthetase (glutamine-hydrolyzing)"
REACT:R-MMU-428961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by MAPK p38 alpha (Mus musculus)
REACT:R-RNO-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Rattus norvegicus)
RHEA:13563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+) => H2O + meso-2,6-diaminoheptanedioate + NADP(+)
RHEA:58497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + H(+) + NADH + O2 => glycolaldehyde + H2O + NAD(+) + trimethylamine
RHEA:44513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine
REACT:R-DRE-109341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Danio rerio)
REACT:R-DRE-8876484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC2 transfers CHOL to NPC1 (Danio rerio)
RHEA:15281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lathosterol = 5alpha-cholest-8-en-3beta-ol
RHEA:15281	skos:prefLabel	"cholestenol Delta-isomerase"
RHEA:15281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholestenol Delta-isomerase"
RHEA:47259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SCE-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Saccharomyces cerevisiae)
GO:0003885	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinono-1,4-lactone:oxygen oxidoreductase activity
GO:0003885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinono-1,4-lactone oxidase activity
REACT:R-DRE-5358579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase delta polymerizes DNA across single stranded gap (Danio rerio)
REACT:R-CFA-397891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:G12/13 (active) dissociate (Canis familiaris)
RHEA:62767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:22945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5beta-pregnane-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH
RHEA:68135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytol + tetradecanoyl-CoA <=> CoA + tetradecanoate phytyl ester
RHEA:60772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 = 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate
REACT:R-RNO-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Rattus norvegicus)
REACT:R-RNO-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Rattus norvegicus)
REACT:R-BTA-9726949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIR binds PTGIR agonists (Bos taurus)
RHEA:20103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein] => a long-chain fatty acid + ATP + L-cysteinyl-[protein]
RHEA:38406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)
RHEA:52800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tenuazonic acid synthetase"
RHEA:52800	skos:prefLabel	"tenuazonic acid synthetase"
RHEA:52800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + ATP + L-isoleucine = AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid
RHEA:34109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA => glycine + H(+) + hexadecanoyl-CoA
REACT:R-SCE-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Saccharomyces cerevisiae)
REACT:R-DDI-112429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of FACT complex (Dictyostelium discoideum)
REACT:R-DRE-5687465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds RBBP8 (Danio rerio)
REACT:R-MMU-9007882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 is cleaved (Mus musculus)
REACT:R-HSA-193393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Homo sapiens)
REACT:R-CFA-8873834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 transports PC from ER membrane to lamellar body membrane (Canis familiaris)
REACT:R-DDI-76590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => IMP + NH4+ (AMPD) (Dictyostelium discoideum)
REACT:R-XTR-141156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL-mediated dimerization of procaspase-8 (Xenopus tropicalis)
RHEA:42023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-dehydrocorticosterone + NAD(+) <=> H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone
REACT:R-DME-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Drosophila melanogaster)
RHEA:41039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA
RHEA:51136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate
RHEA:15892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamine <=> L-glutamate + NH4(+)
RHEA:39592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O
REACT:R-CEL-71552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Caenorhabditis elegans)
REACT:R-MMU-5422942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXRA:PPARD binds FABP5:atRA (Mus musculus)
RHEA:32444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DDI-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Dictyostelium discoideum)
GO:0102966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidoyl-CoA:1-dodecanol O-acyltransferase activity
REACT:R-DRE-2161999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Danio rerio)
REACT:R-MMU-5638006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL3 hydrolyzes GTP (Mus musculus)
RHEA:10291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-rhamnono-1,4-lactone <=> H(+) + L-rhamnonate
REACT:R-BTA-73920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Bos taurus)
REACT:R-RNO-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Rattus norvegicus)
RHEA:43708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + hexadecanoate = diphosphate + hexadecanoyl-AMP
REACT:R-CFA-6803789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Canis familiaris)
RHEA:22273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-PFA-8851356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase5 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
RHEA:66919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9603719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)
REACT:R-MMU-421833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Mus musculus)
REACT:R-DME-1483004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho is phosphorylated to PCho by CHK dimer (Drosophila melanogaster)
RHEA:28929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+) => 3,4,5-trihydroxybenzoate + O2
RHEA:31538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginine + O2 <=> (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate
RHEA:10685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-tyrosyl-[protein] => L-tyrosyl-[protein] + phosphate
REACT:R-XTR-5690759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Xenopus tropicalis)
RHEA:17658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + dihydroxyacetone phosphate => a 1-acylglycerone 3-phosphate + CoA
REACT:R-GGA-6784861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG binds LPL dimer (Gallus gallus)
RHEA:48571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chlorocatechol + O2 <=> (2E,4Z)-2-chloromuconate + 2 H(+)
REACT:R-DRE-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Danio rerio)
RHEA:45060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl) ethanolamine = (9Z)-octadecenoate + ethanolamine
RHEA:72211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isoborneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH
RHEA:31834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> delta-guaiene + diphosphate
GO:0046576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity
GO:0046576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnogalacturonase B activity
REACT:R-CEL-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Caenorhabditis elegans)
REACT:R-MMU-9754964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA deamidates RBV (Mus musculus)
RHEA:43852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + triacontanoyl-CoA = 3-oxo-dotriacontanoyl-CoA + CO2 + CoA
REACT:R-HSA-9759206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Homo sapiens)
EC:2.4.1.48	skos:prefLabel	"heteroglycan alpha-mannosyltransferase"
EC:2.4.1.48	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heteroglycan alpha-mannosyltransferase"
RHEA:48225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + L-fucose
REACT:R-SSC-380283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Sus scrofa)
REACT:R-SCE-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Saccharomyces cerevisiae)
RHEA:13880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde
REACT:R-RNO-5687284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMBT1 binds SFTPD 12mer, SFTPAs (Rattus norvegicus)
REACT:R-DDI-156723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF20A (MKL2) by phosphorylation (Dictyostelium discoideum)
RHEA:58371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) <=> (2E,6Z)-nona-2,6-dienal + H(+) + NADPH
REACT:R-SSC-5683384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UIMC1 and FAM175A bind DNA DSBs (Sus scrofa)
RHEA:15370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + O2 => 2-carboxy-cis,cis-muconate + 2 H(+)
REACT:R-DME-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)
REACT:R-SSC-5654664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS binds GRB2:SOS1 (Sus scrofa)
REACT:R-HSA-1295622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 binds CBL (Homo sapiens)
REACT:R-DME-199202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphopantetheine conjugation of the ACP domain of FAS (Drosophila melanogaster)
EC:2.1.1.123	skos:prefLabel	"[cytochrome c]-methionine S-methyltransferase"
EC:2.1.1.123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[cytochrome c]-methionine S-methyltransferase"
RHEA:27791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-all-trans-octaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)
REACT:R-MMU-9667456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B bind desmopressin (Mus musculus)
REACT:R-DDI-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Dictyostelium discoideum)
RHEA:13947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelate => (S)-mandelate
RHEA:26036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-3900194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates DDX5 with SUMO2 (Rattus norvegicus)
REACT:R-RNO-4093336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
REACT:R-HSA-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)
REACT:R-MMU-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Mus musculus)
REACT:R-XTR-9653592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Xenopus tropicalis)
REACT:R-CFA-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Canis familiaris)
REACT:R-HSA-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Homo sapiens)
RHEA:61506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin 3-O-beta-D-glucoside + UDP => pelargonidin + UDP-alpha-D-glucose
RHEA:54246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline
RHEA:18459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+) => D-ribulose 5-phosphate
REACT:R-CFA-190260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b binds to FGF (Canis familiaris)
REACT:R-RNO-193668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR and RHOA-GDI interact (Rattus norvegicus)
GO:0033862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine monophosphate kinase activity
GO:0033862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:UMP phosphotransferase activity
GO:0033862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMP kinase activity
GO:0033862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SmbA
GO:0033862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PyrH
GO:0033862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UMP-kinase activity
GO:0033862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UMPK
REACT:R-MMU-6794346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind NLGNs (Mus musculus)
REACT:R-HSA-198955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)
RHEA:17897	skos:altLabel	"ethylbenzene dehydrogenase"
RHEA:17897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ethylbenzene + H2O = (S)-1-phenylethanol + AH2
RHEA:17897	skos:prefLabel	"ethylbenzene hydroxylase"
RHEA:17897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethylbenzene hydroxylase"
REACT:R-DDI-8870465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT binds the RAB-binding subunit (Dictyostelium discoideum)
REACT:R-MMU-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Mus musculus)
REACT:R-CFA-5696945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP33 deubiquitinates CCP110,ARRB (Canis familiaris)
REACT:R-HSA-112124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxidative demethylation of 3-meC damaged DNA By ALKBH3 (Homo sapiens)
RHEA:59204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)
REACT:R-HSA-5629237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH (Homo sapiens)
REACT:R-MMU-9661425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB dissociates (Mus musculus)
REACT:R-HSA-5686900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53BP1 recruits DCLRE1C to ATM (Homo sapiens)
RHEA:17113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine-phosphoethanolamine = H(+) + L-serine + phosphoethanolamine
RHEA:17113	skos:prefLabel	"serine-ethanolaminephosphate phosphodiesterase"
RHEA:17113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine-ethanolaminephosphate phosphodiesterase"
RHEA:56234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O
RHEA:19622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 3'-phosphate + H(+)
EC:2.8.2.39	skos:prefLabel	"hydroxyjasmonate sulfotransferase"
EC:2.8.2.39	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxyjasmonate sulfotransferase"
RHEA:70822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoarginine(in) + L-ornithine(out) <=> L-homoarginine(out) + L-ornithine(in)
REACT:R-HSA-5672083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KTN1 binds Kinesin-1 (Homo sapiens)
REACT:R-SSC-8952062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 recruits HDAC4 to RUNX3 (Sus scrofa)
REACT:R-GGA-9009936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEL cleaves cellular ssRNA (Gallus gallus)
RHEA:68051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-D-aspartate + S-adenosyl-L-methionine <=> [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine
RHEA:49723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NAD(+) + violacein
RHEA:15650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamate + 2 H(+) => CO2 + NH4(+)
RHEA:35217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphate + XMP => H2O + XDP
REACT:R-GGA-9648268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A antagonists (Gallus gallus)
REACT:R-PFA-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Plasmodium falciparum)
RHEA:13904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(aminomethyl)urea <=> N-(hydroxymethyl)urea + NH4(+)
RHEA:39644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH => (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)
REACT:R-MMU-6804425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F2 (Mus musculus)
RHEA:48643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) <=> 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH
REACT:R-HSA-192624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cRNA Extension (Homo sapiens)
REACT:R-SPO-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)
REACT:R-DRE-5368596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Danio rerio)
REACT:R-BTA-8938853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK6 binds RUNX1 (Bos taurus)
RHEA:71403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] = 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:64031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine <=> H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine
RHEA:57003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + streptothricin F <=> CoA + H(+) + N(beta)-acetylstreptothricin F
REACT:R-RNO-3222116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L3MBTL1 binds TP53 monomethylated on K382 (Rattus norvegicus)
RHEA:41421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 => CO2 + grixazone B + 4 H2O
REACT:R-DRE-164651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from ubiquinol to cytochrome c of complex III (Danio rerio)
REACT:R-CFA-139855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X1-mediated entry of Ca++ from plasma (Canis familiaris)
REACT:R-MMU-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Mus musculus)
GO:0008238	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	exoprotease activity
GO:0008238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exopeptidase activity
REACT:R-CEL-1889978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALT6 transfers Gal to the tetrasaccharide linker (Caenorhabditis elegans)
REACT:R-DME-6785933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT8 transfers Gal from UDP-Gal to CERA (Drosophila melanogaster)
REACT:R-RNO-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Rattus norvegicus)
RHEA:39961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + hexadecanoate => 1-hexadecanoylglycerol + H2O
RHEA:60842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]
RHEA:63259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)
RHEA:43299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate
GO:0090554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate
GO:0090554	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-coupled phosphatidylcholine transporter activity
GO:0090554	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylcholine-translocating ATPase activity
GO:0090554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine floppase activity (cytosolic to exoplasmic leaftlet)
GO:0090554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine floppase activity
GO:0090554	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP-dependent phosphatidylcholine transporter activity
REACT:R-SCE-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Saccharomyces cerevisiae)
RHEA:47716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pregnen-20,21-diol-3-one + NAD(+) = 21-hydroxyprogesterone + H(+) + NADH
REACT:R-BTA-6786070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Bos taurus)
GO:0018496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity
RHEA:36525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA
RHEA:41191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate
RHEA:29699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide(in) = dimethyl sulfoxide(out)
REACT:R-GGA-5658435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs bind RAS:GTP (Gallus gallus)
RHEA:43455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA
REACT:R-BTA-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Bos taurus)
REACT:R-SSC-5668714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX1 complex (Sus scrofa)
GO:0102557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protopanaxadiol 6-hydroxylase activity
REACT:R-BTA-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Bos taurus)
REACT:R-CFA-9013143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GEFs activate RAC1 (Canis familiaris)
REACT:R-SSC-8876283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Sus scrofa)
RHEA:63193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 => glycine betaine + 2 H(+) + phosphate
GO:0106360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methylhexadecanoyl-CoA lyase activity
GO:0106360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA
GO:0047050	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-hydroxy fatty acid oxidase
GO:0047050	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-hydroxystearate:NAD+ oxidoreductase activity
GO:0047050	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-hydroxy fatty acid dehydrogenase activity
GO:0047050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxy-fatty acid dehydrogenase activity
GO:0047050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxy-fatty-acid dehydrogenase activity
GO:0047050	skos:prefLabel	"(S)-2-hydroxy-fatty-acid dehydrogenase"
GO:0047050	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, L-2-hydroxy fatty acid
GO:0047050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + H(+) + NADH
GO:0047050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-2-hydroxy-fatty-acid dehydrogenase"
GO:0047050	skos:altLabel	"L-2-hydroxy fatty acid dehydrogenase"
REACT:R-HSA-8985123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEL binds 2'-5' oligoadenylate (Homo sapiens)
RHEA:48467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1b + H2O <=> ganglioside GA1 + N-acetylneuraminate
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamyl phosphate synthetase (glutamine) activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPS activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate synthase (glutamine-hydrolyzing) activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoylphosphate synthetase II activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl phosphate synthetase activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine-dependent carbamyl phosphate synthetase activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GD-CPSase activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamine-dependent carbamoyl-phosphate synthase activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity
GO:0004088	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate synthase (glutamine-hydrolysing) activity
RHEA:51616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + formate + H(+) = CO2 + dATP + H2O
RHEA:69511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamino-1,5-lactone <=> H(+) + N-acetyl-D-glucosaminate
RHEA:69556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + H(+)(out) = D-glucose(in) + H(+)(in)
GO:0047531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,5-diaminovalerate transaminase"
GO:0047531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diamino-acid transaminase activity
GO:0047531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diaminovalerate aminotransferase activity
GO:0047531	skos:altLabel	"2,5-diaminovalerate aminotransferase"
GO:0047531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,5-diaminopentanoate:2-oxoglutarate aminotransferase activity
GO:0047531	skos:prefLabel	"2,5-diaminovalerate transaminase"
GO:0047531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diamino-acid aminotransferase activity
GO:0047531	skos:altLabel	"diamino-acid aminotransferase"
GO:0047531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diaminovalerate transaminase activity
GO:0047531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diamino acid aminotransferase activity
GO:0047531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ornithine = 5-amino-2-oxopentanoate + L-glutamate
RHEA:54087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine <=> archaeosine(15) in tRNA + L-glutamate
REACT:R-MMU-5665767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FMNL3 binds G-actin (Mus musculus)
REACT:R-MMU-5635741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Mus musculus)
REACT:R-GGA-201445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Gallus gallus)
RHEA:46106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:52399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-D-threonate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH
REACT:R-HSA-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)
REACT:R-HSA-936986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains (Homo sapiens)
RHEA:49049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]
REACT:R-CEL-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)
REACT:R-DRE-975608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP2:atROL and FACYLs to atREs (Danio rerio)
REACT:R-XTR-1981120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Xenopus tropicalis)
REACT:R-RNO-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
REACT:R-SSC-975593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Sus scrofa)
REACT:R-CEL-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)
REACT:R-GGA-421447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protoporphyrin IX + Fe++ => heme + 2 H+ (Gallus gallus)
RHEA:29789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathione(out) + H(+) + phosphate => ATP + glutathione(in) + H2O
REACT:R-DRE-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Danio rerio)
REACT:R-CEL-182993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL) (Caenorhabditis elegans)
REACT:R-MMU-3322434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP dissociates from ub-TLE (Mus musculus)
REACT:R-RNO-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)
RHEA:58070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + vanillin => O2 + trans-isoeugenol
GO:0005237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inhibitory extracellular ligand-gated ion channel activity
REACT:R-CFA-6811472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IER3 recruits MAPKs to PP2A-B56-beta,gamma (Canis familiaris)
RHEA:47659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-methionine sulfone <=> CoA + H(+) + N-acetyl-L-methionine sulfone
REACT:R-HSA-1980123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX recruits beta-arrestin (ARRB) to NOTCH (Homo sapiens)
REACT:R-PFA-1676134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)
RHEA:50288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate
REACT:R-HSA-5654422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS2 (Homo sapiens)
REACT:R-BTA-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Bos taurus)
REACT:R-DME-6807206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)
REACT:R-XTR-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Xenopus tropicalis)
RHEA:61490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(50) in tRNA + S-adenosyl-L-methionine
REACT:R-SPO-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Schizosaccharomyces pombe)
REACT:R-HSA-8853317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3 fusions dimerize (Homo sapiens)
RHEA:32896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-5693533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C (ARTEMIS) processes DNA DSB ends (Sus scrofa)
REACT:R-GGA-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Gallus gallus)
REACT:R-HSA-5626981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Homo sapiens)
REACT:R-SSC-450474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates BRF1 (Sus scrofa)
RHEA:70874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-valine(out) + Na(+)(out) <=> L-glutamine(out) + L-valine(in) + Na(+)(in)
RHEA:28732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-leucine(in) => H(+)(in) + L-leucine(out)
REACT:R-BTA-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Bos taurus)
RHEA:47677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-galactosamine => ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate
REACT:R-SSC-1299318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TASK (Sus scrofa)
REACT:R-MMU-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Mus musculus)
REACT:R-XTR-937311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP12A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)
RHEA:36065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + kunzeaol => (2E,6E)-farnesyl diphosphate + H2O
GO:0042876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldarate transmembrane transporter activity
RHEA:46069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-nonenoyl-CoA => (2E)-nonenoyl-CoA
GO:0003938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP dehydrogenase activity
GO:0003938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosinic acid dehydrogenase activity
GO:0003938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine monophosphate dehydrogenase activity
GO:0003938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP oxidoreductase activity
GO:0003938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine-5'-phosphate dehydrogenase activity
GO:0003938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMP:NAD+ oxidoreductase activity
GO:0003938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosinate dehydrogenase activity
GO:0003938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine monophosphate oxidoreductase activity
GO:0003938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inosine 5'-monophosphate dehydrogenase activity
REACT:R-MMU-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Mus musculus)
REACT:R-CFA-9013023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GEFs activate RHOB (Canis familiaris)
REACT:R-GGA-2404193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1R phosphorylates SHC1 (Gallus gallus)
REACT:R-XTR-9621179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cinaciguat binds sGC:NO (Xenopus tropicalis)
REACT:R-DRE-5654730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Danio rerio)
EC:3.4.21.99	skos:prefLabel	"spermosin"
EC:3.4.21.99	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spermosin"
RHEA:38144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon disulfide + 2 H2O => CO2 + 2 H(+) + 2 hydrogen sulfide
GO:0102968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxygeranial oxidoreductase activity
RHEA:64142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + L-asparagine => an N-(fatty acyl)-L-asparagine + H2O
RHEA:57737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-3,4-didehydro-13,14-dihydroretinol => AH2 + all-trans-3,4-didehydroretinol
REACT:R-MMU-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Mus musculus)
RHEA:59649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotriono-1,5-lactone + H2O => D-xylotrionate + H(+)
RHEA:31960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-9731661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Drosophila melanogaster)
REACT:R-SSC-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Sus scrofa)
REACT:R-DDI-68688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC6 association with ORC(1-6) at replication origins (Dictyostelium discoideum)
REACT:R-CEL-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Caenorhabditis elegans)
RHEA:50693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate => ADP + alpha-maltose 1-phosphate + H(+)
GO:0140164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COG complex binding
GO:0140164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Golgi transport complex binding
RHEA:45522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] => phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]
RHEA:37322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-methionine(out) + H2O <=> ADP + glycyl-L-methionine(in) + H(+) + phosphate
REACT:R-HSA-8849891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-3 bind to PSD-95 family members (Homo sapiens)
GO:0047835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-tryptophan acetyltransferase activity
GO:0047835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophan N-acetyltransferase activity
GO:0047835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity
GO:0047835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:D-tryptophan N-acetyltransferase activity
RHEA:11832	skos:altLabel	"cis-naphthalene dihydrodiol dehydrogenase"
RHEA:11832	skos:prefLabel	"cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase"
RHEA:11832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) = H(+) + NADH + naphthalene-1,2-diol
RHEA:11832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase"
RHEA:11832	skos:altLabel	"cis-dihydrodiol naphthalene dehydrogenase"
RHEA:27344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + NH4(+) + O2 <=> A + H(+) + H2O + hydroxylamine
REACT:R-RNO-5654709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
RHEA:15096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate
REACT:R-BTA-2213243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of COPII vesicle with Golgi complex (Bos taurus)
RHEA:70480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) => 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
GO:0005319	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lipophorin
GO:0005319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP lipidates APOB-100, forming a pre-VLDL (Homo sapiens)
GO:0005319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid transporter activity
GO:0005319	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	apolipoprotein
REACT:R-MMU-177671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Mus musculus)
RHEA:32105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + trans-resveratrol
REACT:R-DME-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-CFA-2574840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA facilitates AURKA autophosphorylation (Canis familiaris)
RHEA:60626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O
EC:1.2.1.92	skos:prefLabel	"3,6-anhydro-alpha-L-galactose dehydrogenase"
EC:1.2.1.92	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,6-anhydro-alpha-L-galactose dehydrogenase"
REACT:R-HSA-5607731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
RHEA:17318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H(+) + phytyl diphosphate => chlorophyll a + diphosphate
REACT:R-GGA-445700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Gallus gallus)
GO:0019979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-4 binding
GO:0019979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-4 binding
REACT:R-GGA-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Gallus gallus)
REACT:R-CFA-448629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL33 binds IL1RL1 (Canis familiaris)
REACT:R-CEL-425661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
REACT:R-BTA-6803753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAAA hydrolyses NAEs to FAs and ethanolamine (Bos taurus)
RHEA:72467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 6 CO2 + 8 CoA + H2O + o-orsellinate depside
REACT:R-DRE-6813720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCEH1 hydrolyzes cholesterol esters (Danio rerio)
REACT:R-SSC-158333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Sus scrofa)
REACT:R-SSC-351987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A6-mediated uptake of taurine and beta-alanine (Sus scrofa)
RHEA:16216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP
REACT:R-HSA-3000335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Homo sapiens)
REACT:R-MMU-9624272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMPs cleave HB-EGF (Mus musculus)
REACT:R-SPO-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Schizosaccharomyces pombe)
RHEA:18740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + hydrogenselenide <=> AMP + 2 H(+) + phosphate + selenophosphate
REACT:R-HSA-110368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)
REACT:R-HSA-2395257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-hydroxylysino-norleucine cross-links (Homo sapiens)
RHEA:23303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2Z,6E)-farnesyl diphosphate + diphosphate
REACT:R-RNO-2161792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Rattus norvegicus)
RHEA:47018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O
REACT:R-MMU-8944218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VIII (Mus musculus)
REACT:R-CFA-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Canis familiaris)
REACT:R-RNO-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Rattus norvegicus)
RHEA:35224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-dADP + H2O => 2-oxo-dAMP + H(+) + phosphate
GO:0044689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FO synthase
GO:0044689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity
REACT:R-RNO-9033961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Rattus norvegicus)
RHEA:56439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-HSA-9730488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 nsp16 binds to U2 snRNA (Homo sapiens)
RHEA:15218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone + hexadecanoyl-CoA => CoA + ecdysone hexadecanoate
RHEA:15094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-glutamate
REACT:R-DME-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Drosophila melanogaster)
GO:0070548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine aminotransferase activity
RHEA:48207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-RNO-70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Rattus norvegicus)
RHEA:52192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0071795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K11-linked polyubiquitin modification-dependent protein binding
REACT:R-DRE-9013023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GEFs activate RHOB (Danio rerio)
RHEA:61503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delphinidin + UDP-alpha-D-glucose <=> delphinidin 3-O-beta-D-glucoside + UDP
RHEA:58725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine
REACT:R-HSA-203565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)
REACT:R-SSC-5662608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds cadmium (Sus scrofa)
RHEA:44208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyltridecanoate + ATP + CoA = 12-methyltridecanoyl-CoA + AMP + diphosphate
REACT:R-CFA-212710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)
REACT:R-DME-8943780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 recruits NuRD to PTEN gene (Drosophila melanogaster)
REACT:R-XTR-6799097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates ZNF420 (Xenopus tropicalis)
REACT:R-CEL-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Caenorhabditis elegans)
REACT:R-BTA-8851900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1-2 bound to MET recruits GRB2:SOS1 (Bos taurus)
REACT:R-RNO-5689973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10,USP24,USP42 deubiquitinate TP53 (Rattus norvegicus)
RHEA:18620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + oxaloacetate <=> ADP + CO2 + phosphoenolpyruvate
REACT:R-DRE-193981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 oxidises 17HPROG (Danio rerio)
RHEA:31041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + FADH2 => dodecanoyl-CoA + FAD + H(+)
RHEA:70767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)
RHEA:20273	skos:altLabel	"phenylalanine 4-hydroxylase"
RHEA:20273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
RHEA:20273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylalanine 4-monooxygenase"
RHEA:20273	skos:altLabel	"PAH"
RHEA:20273	skos:altLabel	"phenylalaninase"
RHEA:20273	skos:altLabel	"phenylalanine hydroxylase"
RHEA:20273	skos:prefLabel	"phenylalanine 4-monooxygenase"
GO:0102273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homophytochelatin synthase (dimmer forming) activity
REACT:R-HSA-975103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Homo sapiens)
REACT:R-SSC-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Sus scrofa)
RHEA:49731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NADP(+) + violacein
REACT:R-CEL-2534096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METAP1/2 demethylates GNAT1 (Caenorhabditis elegans)
REACT:R-XTR-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Xenopus tropicalis)
REACT:R-MMU-870269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gastrin binds to CCK-B receptor (Mus musculus)
REACT:R-MMU-1678841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Mus musculus)
GO:0102444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isorhamnetin 3-O-methyltransferase activity
REACT:R-GGA-212614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamine transport from astrocytes (Gallus gallus)
REACT:R-HSA-8944257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIV (Homo sapiens)
REACT:R-SSC-5654402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
REACT:R-DRE-8853419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 promotes AURKA autophosphorylation (Danio rerio)
REACT:R-XTR-8987161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Xenopus tropicalis)
REACT:R-DDI-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Dictyostelium discoideum)
REACT:R-CEL-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Caenorhabditis elegans)
REACT:R-RNO-1254386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 forms a complex with estrogen receptor ESR1 (Rattus norvegicus)
RHEA:61452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + oxytetracycline = 11a-hydroxy-oxytetracycline + H2O + NADP(+)
RHEA:37405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA
RHEA:37986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol
REACT:R-CFA-9736953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN translocates to the plasma membrane (Canis familiaris)
REACT:R-XTR-1855197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)
REACT:R-GGA-2731078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 2, (4) bind TGFB1 (Gallus gallus)
GO:0035991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NO sensor activity
GO:0035991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitric oxide sensor activity
REACT:R-CFA-193073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Canis familiaris)
REACT:R-XTR-1112727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serine phosphorylation of STATs (Xenopus tropicalis)
REACT:R-RNO-2029272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of PLCG from FCGR (Rattus norvegicus)
REACT:R-SSC-375384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bombesin-like receptors bind bombesin homologues (Sus scrofa)
REACT:R-CFA-442291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV2 is a GEF for Rho/Rac family kinases (Canis familiaris)
REACT:R-RNO-5671749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 phosphorylates CDC25C (Rattus norvegicus)
RHEA:15800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin IXalpha + NAD(+) <=> biliverdin IXalpha + H(+) + NADH
RHEA:12136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)
RHEA:12136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]"
RHEA:12136	skos:prefLabel	"2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]"
RHEA:12136	skos:altLabel	"4-enoyl-CoA reductase (NADPH)"
RHEA:12136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) = a (2E,4E)-dienoyl-CoA + H(+) + NADPH
RHEA:12136	skos:altLabel	"2,4-dienoyl-CoA reductase (NADPH)"
REACT:R-SSC-174157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cyclin B (Sus scrofa)
REACT:R-BTA-6807868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates ARF nucleotide exchange (Bos taurus)
RHEA:39578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)
RHEA:59359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lactobiono-1,5-lactone <=> H(+) + lactobionate
REACT:R-RNO-3000074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN2 binds RCbl in the circulation (Rattus norvegicus)
RHEA:40814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-PFA-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Plasmodium falciparum)
RHEA:58297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine => 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine
REACT:R-SSC-2161613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Sus scrofa)
RHEA:52504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:27926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMP(in) = UMP(out)
REACT:R-GGA-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Gallus gallus)
REACT:R-DDI-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Dictyostelium discoideum)
REACT:R-HSA-164528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase H-mediated cleavage of the template strand (Homo sapiens)
GO:0050447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zeatin 9-aminocarboxyethyltransferase activity
GO:0050447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)
GO:0050447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lupinate synthetase activity
GO:0050447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-(9-cytokinin)-alanine synthase activity
GO:0050447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity
GO:0050447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lupinic acid synthase activity
GO:0050447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity
GO:0050447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-(9-cytokinin)alanine synthase activity
GO:0050447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lupinic acid synthetase activity
GO:0050447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity
REACT:R-GGA-177939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
REACT:R-HSA-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Homo sapiens)
REACT:R-HSA-168285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion (Homo sapiens)
GO:0009010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-sorbitol 6-phosphate dehydrogenase activity
GO:0009010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-sorbitol-6-phosphate dehydrogenase activity
GO:0009010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sorbitol-6-P-dehydrogenase activity
GO:0009010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucitol-6-phosphate dehydrogenase activity
GO:0009010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ketosephosphate reductase activity
GO:0009010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucitol-6-phosphate dehydrogenase activity
GO:0009010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbitol-6-phosphate 2-dehydrogenase activity
GO:0009010	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity
GO:0018569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroquinone 1,2-dioxygenase activity
RHEA:31822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> 5-epi-alpha-selinene + diphosphate
REACT:R-BTA-2872497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-2 transports cytosolic urate to extracellular region (Bos taurus)
REACT:R-GGA-174171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A with the APC/C (Gallus gallus)
REACT:R-SSC-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Sus scrofa)
REACT:R-SSC-428127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Sus scrofa)
RHEA:28184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate
RHEA:41442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate => (2-aminoethyl)phosphonate + 2-oxoglutarate + O2
REACT:R-DDI-507775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K341-GPT2 transaminates L-Ala to form PYR (Dictyostelium discoideum)
RHEA:68268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + formaldehyde + H(+) + NADPH = dTMP + H2O + NADP(+)
RHEA:13812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspulvinone E + 2 dimethylallyl diphosphate <=> aspulvinone H + 2 diphosphate
REACT:R-GGA-8850560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha releases G-protein heterotrimer from PDCL  (Gallus gallus)
GO:1904769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentadecanoic acid binding
GO:1904769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-methylmyristic acid binding
REACT:R-RNO-5654147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PLCG1 (Rattus norvegicus)
RHEA:44314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + tetradecanoate => 1-tetradecanoylglycerol + H2O
REACT:R-DRE-1855182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Danio rerio)
REACT:R-RNO-163751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Rattus norvegicus)
RHEA:53016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorohydroquinone + 2 glutathione = chloride + glutathione disulfide + H(+) + hydroquinone
REACT:R-CEL-396996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs binds G-protein Gq (Caenorhabditis elegans)
GO:0052908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GO:0052908	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase activity
RHEA:48874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a gentamycin 2''-phosphate + GDP + H(+) => a gentamycin + GTP
REACT:R-DRE-191382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Danio rerio)
REACT:R-SPO-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Schizosaccharomyces pombe)
REACT:R-RNO-373747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of nephrin by FYN (Rattus norvegicus)
REACT:R-DDI-1369028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid efflux (Dictyostelium discoideum)
REACT:R-HSA-381668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP activates EPAC1 (Homo sapiens)
RHEA:63258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) => 1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O
RHEA:28832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate(in) + H(+)(in) => D-gluconate(out) + H(+)(out)
RHEA:65954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a 1,4-benzosemiquinone + NAD(+) => 2 a quinone + H(+) + NADH
REACT:R-BTA-170131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Bos taurus)
REACT:R-SSC-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Sus scrofa)
REACT:R-CFA-9611839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β3-agonists bind ADRB3 (Canis familiaris)
RHEA:16938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycerol + ATP => 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DRE-444527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPR is a receptor for formyl peptides (Danio rerio)
RHEA:40419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phytanoyl-CoA = 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)
REACT:R-HSA-74740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SHC1 to insulin receptor (Homo sapiens)
RHEA:66031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine <=> (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
RHEA:55871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + O2 <=> H2O2 + pyruvate
RHEA:15032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + NAD(+) <=> D-mannose + H(+) + NADH
REACT:R-DME-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Drosophila melanogaster)
REACT:R-DRE-4341070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PPARA with SUMO1 (Danio rerio)
RHEA:28356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + FADH2 => decanoyl-CoA + FAD + H(+)
REACT:R-HSA-351894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of BAP31 (Homo sapiens)
RHEA:40386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
REACT:R-CFA-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Canis familiaris)
REACT:R-CFA-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Canis familiaris)
RHEA:61156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-dephospho-CoA + GTP = CoA + GDP + H(+)
RHEA:28433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allose 6-phosphate <=> D-allulose 6-phosphate
RHEA:20132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O <=> adenine + D-ribose 5-phosphate
REACT:R-CEL-5244692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)
GO:0043760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyldiaminopimelate aminotransferase activity
GO:0043760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L,L-diaminopimelate aminotransferase activity
GO:0043760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-diaminopimelate aminotransferase activity
GO:0010290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll catabolite transmembrane transporter activity
REACT:R-RNO-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Rattus norvegicus)
RHEA:36855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-L-cysteine-S-conjugate + H2O = acetate + an S-substituted L-cysteine
REACT:R-MMU-5676598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:cIAP1/2 complex binds FN14:TWEAK (Mus musculus)
RHEA:35215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XDP = H(+) + phosphate + XMP
REACT:R-HSA-8950718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TCP1 (Homo sapiens)
REACT:R-GGA-9014433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG GEFs activate RHOG (Gallus gallus)
RHEA:52859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine
RHEA:61726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-dehydro-D-glucoside + H(+) + NADH => a D-glucoside + NAD(+)
REACT:R-HSA-6809011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
REACT:R-BTA-1363314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) binds CyclinE/A:CDK2 (Bos taurus)
RHEA:66390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + prostaglandin E2(out) => ATP + H2O + prostaglandin E2(in)
EC:2.3.1.100	skos:altLabel	"acyl-protein synthase"
EC:2.3.1.100	skos:altLabel	"myelin PLP acyltransferase"
EC:2.3.1.100	skos:prefLabel	"[myelin-proteolipid] O-palmitoyltransferase"
EC:2.3.1.100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[myelin-proteolipid] O-palmitoyltransferase"
RHEA:62139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + GTP <=> dGDP + GDP
REACT:R-MMU-5654573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds SHC1 (Mus musculus)
REACT:R-HSA-9614816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)
REACT:R-SSC-5654701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
RHEA:23675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + L-quinate <=> 3-dehydroquinate + a quinol
GO:0140080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endonuclease IV
GO:0140080	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endonuclease III
GO:0140080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity
REACT:R-BTA-193702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of the ICD migrates to the nucleus (Bos taurus)
REACT:R-DRE-1793209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses Chondroitin chains (Danio rerio)
REACT:R-GGA-9708866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-F2R binds vorapaxar (Gallus gallus)
RHEA:18709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taurine dehydrogenase"
RHEA:18709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + taurine = AH2 + NH4(+) + sulfoacetaldehyde
RHEA:18709	skos:prefLabel	"taurine dehydrogenase"
REACT:R-HSA-2022393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8) (Homo sapiens)
RHEA:35665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O
RHEA:53226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-211191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF with alpha:beta importin (Drosophila melanogaster)
RHEA:28299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate
GO:0045430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chalcone-flavanone isomerase activity
GO:0045430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavanone lyase (decyclizing)
GO:0045430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chalcone isomerase activity
GO:0045430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chalcone--flavonone isomerase activity
REACT:R-XTR-2065357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)
GO:0042731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PH domain binding
REACT:R-XTR-8959719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPK phosphorylates Sedo to Sedo7P (Xenopus tropicalis)
RHEA:21036	skos:prefLabel	"acetyl-CoA C-acetyltransferase"
RHEA:21036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetyl-CoA C-acetyltransferase"
RHEA:21036	skos:altLabel	"acetoacetyl-CoA thiolase"
RHEA:21036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA = acetoacetyl-CoA + CoA
RHEA:55238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O
REACT:R-XTR-114683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Platelet Sec-1 (Xenopus tropicalis)
RHEA:68609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isatin + NADPH => 3-hydroxyindolin-2-one + NADP(+)
REACT:R-HSA-9011984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A is recruited to MYC and BCL2 genes (Homo sapiens)
REACT:R-BTA-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)
RHEA:65441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
RHEA:33290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + spermidine <=> 1-pyrroline + AH2 + propane-1,3-diamine
REACT:R-PFA-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Plasmodium falciparum)
RHEA:23061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP => a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate
REACT:R-SSC-354097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Talin (Sus scrofa)
REACT:R-RNO-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Rattus norvegicus)
REACT:R-SSC-888589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GABA at the synapse (Sus scrofa)
REACT:R-SSC-71334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Sus scrofa)
GO:0030789	skos:altLabel	"precorrin-3 methyltransferase"
GO:0030789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	precorrin-3 methylase activity
GO:0030789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CobJ
GO:0030789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	precorrin-3 methyltransferase activity
GO:0030789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-3B + S-adenosyl-L-methionine = 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine
GO:0030789	skos:altLabel	"precorrin-3B C17-methyltransferase"
GO:0030789	skos:altLabel	"precorrin-3 methylase"
GO:0030789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"precorrin-3B C(17)-methyltransferase"
GO:0030789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-3B C17-methyltransferase activity
GO:0030789	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity
GO:0030789	skos:prefLabel	"precorrin-3B C(17)-methyltransferase"
REACT:R-DME-8937113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)
RHEA:67058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chermesin D methyl ester + S-adenosyl-L-homocysteine => chermesin D + S-adenosyl-L-methionine
REACT:R-GGA-6791235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds AURKA (Gallus gallus)
EC:3.2.1.102	skos:prefLabel	"blood-group-substance endo-1,4-beta-galactosidase"
EC:3.2.1.102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"blood-group-substance endo-1,4-beta-galactosidase"
EC:3.2.1.102	skos:altLabel	"endo-beta-galactosidase"
REACT:R-DRE-8854051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL18 ubiquitinates FBXL7 (Danio rerio)
RHEA:58317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
RHEA:30368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)alamin 5'-phosphate + H2O => adenosylcob(III)alamin + phosphate
REACT:R-HSA-198270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT at T308 (Homo sapiens)
RHEA:45758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine => (6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2
RHEA:24540	skos:altLabel	"soluble glucose dehydrogenase"
RHEA:24540	skos:prefLabel	"soluble quinoprotein glucose dehydrogenase"
RHEA:24540	skos:altLabel	"glucose dehydrogenase (PQQ-dependent)"
RHEA:24540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"soluble quinoprotein glucose dehydrogenase"
RHEA:24540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-glucose = AH2 + D-glucono-1,5-lactone
REACT:R-XTR-178208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF2 (Xenopus tropicalis)
RHEA:63955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid 1-phosphate + H2O <=> a sphingoid base + phosphate
REACT:R-CEL-5159245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)
RHEA:53756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholoyl-CoA + cholate = allodeoxycholate + choloyl-CoA
RHEA:19759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + oxaloacetate => (3R)-3-hydroxy-L-aspartate
REACT:R-SSC-2395322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyridinoline cross-links (Sus scrofa)
REACT:R-RNO-2028661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of WWTR1 (TAZ) by LATS2 (Rattus norvegicus)
REACT:R-SSC-1008200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 binds the beta globin locus control region (Sus scrofa)
REACT:R-DRE-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Danio rerio)
RHEA:43144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(22) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine
RHEA:43144	skos:prefLabel	"tRNA (adenine(22)-N(1))-methyltransferase"
RHEA:43144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (adenine(22)-N(1))-methyltransferase"
GO:0034020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NSY
GO:0034020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neoxanthin synthase activity
GO:0034020	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	violaxanthin-neoxanthin isomerase (epoxide-opening) activity
REACT:R-MMU-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)
REACT:R-BTA-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Bos taurus)
RHEA:71383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out)
RHEA:66715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate
REACT:R-SCE-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)
RHEA:56884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:19441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+)
REACT:R-MMU-1630304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Mus musculus)
REACT:R-HSA-4084999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU1 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)
REACT:R-MMU-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Mus musculus)
RHEA:43315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(hexanoyl)sphing-4-enine <=> ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate
REACT:R-HSA-9615638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR2 and SOX10 bind the MBP gene (Homo sapiens)
RHEA:51765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + phlorisovalerophenone => 4-prenylphlorisovalerophenone + diphosphate
RHEA:56316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4-hydroxybenzoate + acetyl-CoA = 3-acetylamino-4-hydroxybenzoate + CoA
REACT:R-DME-390061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YKI binds to phosphorylated WTS (Drosophila melanogaster)
GO:0080031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylsalicylate esterase activity
GO:0080031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MESA esterase activity
GO:0080031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl SA esterase activity
GO:0080031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	salicylic acid methyl ester esterase activity
GO:0080031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl salicylate esterase activity
GO:0051675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pullulan 4-glucanohydrolase (isopanose-forming) activity
GO:0051675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopullulanase activity
REACT:R-DRE-374337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apelin receptor binds to apelin (Danio rerio)
RHEA:53403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate
RHEA:53675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O
RHEA:41382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol + H2O + NAD(+) => H(+) + NADH + O2 + toluene
REACT:R-DDI-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)
REACT:R-MMU-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Mus musculus)
REACT:R-SSC-947531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Sus scrofa)
RHEA:47105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + glycine + H2O => 5,6,7,8-tetrahydromethanopterin + L-serine
RHEA:40661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol
REACT:R-MMU-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Mus musculus)
RHEA:16654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + NADP(+) => 2-dehydro-D-gluconate + H(+) + NADPH
RHEA:49907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2
RHEA:53205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-8953037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F8 forms homodimers (Mus musculus)
RHEA:57074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-erythrulose 1-phosphate => 3-oxoisoapionate 4-phosphate + H(+)
REACT:R-XTR-9757578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDN (Xenopus tropicalis)
RHEA:49411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-mannosyl](n) + phosphate <=> [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate
RHEA:25994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-isozizaene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:66231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-C13-CoA + O2 <=> asc-DeltaC13-CoA + H2O2
RHEA:39279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dodecanoate(out) + H2O = ADP + dodecanoate(in) + H(+) + phosphate
RHEA:35873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA
REACT:R-MMU-109857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 binds MAPK3 (Mus musculus)
REACT:R-DME-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Drosophila melanogaster)
RHEA:41722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O
RHEA:22837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]
RHEA:19327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + quinoline-3,4-diol => H(+) + NADH + O2 + quinolin-4-ol
RHEA:40583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanedioyl-CoA = CoA + H(+) + hexanedioate
REACT:R-CFA-3295580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPM4,5 transport extracellular Na+ to cytosol (Canis familiaris)
RHEA:66854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate => (2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate
REACT:R-SPO-429961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCPS scavenges the 7-methylguanosine cap of mRNA (Schizosaccharomyces pombe)
RHEA:71279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-leucine(out) + 2 Na(+)(out) = chloride(in) + L-leucine(in) + 2 Na(+)(in)
RHEA:42840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH = 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)
RHEA:42840	skos:prefLabel	"neocarzinostatin naphthoate synthase"
RHEA:42840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neocarzinostatin naphthoate synthase"
RHEA:42840	skos:altLabel	"naphthoic acid synthase"
REACT:R-XTR-74059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)
REACT:R-MMU-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Mus musculus)
REACT:R-HSA-373700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-9 binds DCC:DIP13alpha complex (Homo sapiens)
RHEA:66871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate
GO:0047682	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arom. alcohol oxidase activity
GO:0047682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2
GO:0047682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aryl-alcohol oxidase"
GO:0047682	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl-alcohol:oxygen oxidoreductase activity
GO:0047682	skos:prefLabel	"aryl-alcohol oxidase"
GO:0047682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryl-alcohol oxidase activity
GO:0047682	skos:altLabel	"veratryl alcohol oxidase"
GO:0047682	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	veratryl alcohol oxidase activity
GO:0047682	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryl alcohol oxidase activity
REACT:R-RNO-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Rattus norvegicus)
RHEA:39743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)
RHEA:32745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + L,L-cystathionine => L-homocysteine + O-acetyl-L-serine
RHEA:71913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate(in) + 2 Na(+)(in) => cholate(out) + 2 Na(+)(out)
REACT:R-RNO-419841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Light stimulates opsin receptors (Rattus norvegicus)
REACT:R-BTA-139906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of BAD by calcineurin (Bos taurus)
RHEA:63015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + orsellinate <=> diphosphate + ilicicolinate B
RHEA:65170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + preaustinoid A1 => AH2 + O2 + preaustinoid A
RHEA:42554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(31) in tRNA => uridine(31) in tRNA
REACT:R-DRE-420595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-2:Nectin 3 trans heterodimer interaction (Danio rerio)
REACT:R-DME-187934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Drosophila melanogaster)
GO:0061654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 conjugating enzyme activity
GO:0061654	skos:prefLabel	"E2 NEDD8-conjugating enzyme"
GO:0061654	skos:altLabel	"NEDD8-carrier-protein E2"
GO:0061654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"E2 NEDD8-conjugating enzyme"
GO:0061654	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E2
GO:0061654	skos:altLabel	"NEDD8-conjugating enzyme E2"
REACT:R-HSA-352052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Homo sapiens)
RHEA:34436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine => 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine
EC:3.1.1.59	skos:altLabel	"JH esterase"
EC:3.1.1.59	skos:prefLabel	"juvenile-hormone esterase"
EC:3.1.1.59	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"juvenile-hormone esterase"
EC:3.1.1.59	skos:altLabel	"methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase"
REACT:R-RNO-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Rattus norvegicus)
RHEA:51787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlorisovalerophenone + dimethylallyl diphosphate <=> deoxyhumulone + diphosphate
REACT:R-HSA-879411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Homo sapiens)
REACT:R-HSA-110211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTHL1 glycosylase mediated recognition and binding of thymine glycol (Homo sapiens)
RHEA:66170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate => [protein]-with a C-terminal TM segment(out) + ATP + H2O
REACT:R-HSA-8850786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK12 (Homo sapiens)
GO:0018715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-phenanthrol UDP-glucuronosyltransferase activity
RHEA:14099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine + oxaloacetate => 3-phenylpyruvate + L-aspartate
REACT:R-SSC-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Sus scrofa)
RHEA:36772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
REACT:R-DRE-9748945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Danio rerio)
GO:0016520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth hormone-releasing hormone receptor activity
RHEA:39290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine <=> dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]
RHEA:13923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
RHEA:71785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate(in) + H(+)(in) => 3-methyl-2-oxobutanoate(out) + H(+)(out)
RHEA:11062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-isoleucyl-tRNA(Ile) => ATP + L-isoleucine + tRNA(Ile)
GO:0016418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-acetyltransferase activity
RHEA:29756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate(in) => (R)-lipoate(out)
REACT:R-RNO-5624948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF17 enters the cilium (Rattus norvegicus)
RHEA:60063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP
REACT:R-CEL-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Caenorhabditis elegans)
RHEA:34813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocurcumin + H(+) + NADPH => NADP(+) + tetrahydrocurcumin
RHEA:50570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein]
REACT:R-XTR-3108209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1 SUMOylates CTBP1 with SUMO1 (Xenopus tropicalis)
REACT:R-RNO-1168642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Rattus norvegicus)
REACT:R-XTR-9749609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCHE hydrolyzes ASA- (Xenopus tropicalis)
REACT:R-GGA-390674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB1 bind ADR,NAd (Gallus gallus)
REACT:R-MMU-170070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Mus musculus)
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta6-fatty acyl-CoA desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fatty acid delta(6)-desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain fatty acid delta6-desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	delta(6)-acyl CoA desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta6-desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	delta6-acyl CoA desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	delta(6)-fatty acyl-CoA desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleoyl-CoA desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleoyl CoA desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	long-chain fatty acid delta(6)-desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleic acid desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	delta(6)-desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleoyl-coenzyme A desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acid delta6-desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleic desaturase activity
GO:0016213	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	fatty acid 6-desaturase activity
RHEA:68924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + hexanoate + NADPH = AMP + diphosphate + hexanal + NADP(+)
RHEA:18222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate
REACT:R-CFA-419011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectins (Canis familiaris)
REACT:R-SSC-1912357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH ubiquitinates DTX (Sus scrofa)
GO:0001587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gq/11-coupled serotonin receptor activity
GO:0001587	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	5-HT2 receptor activity
GO:0001587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serotonin receptor activity, coupled via Gq/11
RHEA:40415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pristanoyl-CoA = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)
REACT:R-CEL-2396029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-3 binds integrins (Caenorhabditis elegans)
REACT:R-CFA-2161917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15S-HpETE to LXA4/B4 (Canis familiaris)
REACT:R-HSA-192677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Newly synthesized vRNP for export (Homo sapiens)
REACT:R-MMU-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Mus musculus)
REACT:R-DDI-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Dictyostelium discoideum)
GO:0050561	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nondiscriminating glutamyl-tRNA synthetase activity
GO:0050561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-tRNA(Gln) ligase activity
GO:0050561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-tRNAGln ligase activity
GO:0050561	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:tRNAGlx ligase (AMP-forming)
REACT:R-MMU-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Mus musculus)
REACT:R-HSA-2395439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DAP12 (Homo sapiens)
RHEA:50610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-leukotriene B4 + H(+) + NADPH => leukotriene B4 + NADP(+)
REACT:R-SSC-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Sus scrofa)
REACT:R-GGA-8878054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 (Gallus gallus)
REACT:R-HSA-9021523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWP2 ubiquitinates NOTCH3 (Homo sapiens)
REACT:R-SSC-2632521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Sus scrofa)
REACT:R-BTA-9750946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
REACT:R-GGA-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Gallus gallus)
REACT:R-SSC-202704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaXbeta2 binds JAM3 (Sus scrofa)
RHEA:65240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + H2O = (11Z)-octadecenoate + CoA + H(+)
REACT:R-BTA-5591052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROCR binds Protein C (Bos taurus)
REACT:R-XTR-8854302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D7 binds the TSC1-TSC2 complex (Xenopus tropicalis)
RHEA:53452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester
RHEA:23386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1->4)-D-mannopyranose => D-cellobiose
REACT:R-RNO-8936519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO2:FAD dimer reduces quinones to hydroquinones (Rattus norvegicus)
REACT:R-HSA-9604480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
REACT:R-SSC-168166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
RHEA:13993	skos:altLabel	"beta-aminoisobutyrate-alpha-ketoglutarate transaminase"
RHEA:13993	skos:altLabel	"L-3-aminoisobutyrate transaminase"
RHEA:13993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-3-amino-2-methylpropionate transaminase"
RHEA:13993	skos:altLabel	"(S)-3-amino-2-methylpropionate aminotransferase"
RHEA:13993	skos:altLabel	"L-3-aminoisobutyrate aminotransferase"
RHEA:13993	skos:altLabel	"beta-aminobutyric transaminase"
RHEA:13993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate
RHEA:13993	skos:prefLabel	"(S)-3-amino-2-methylpropionate transaminase"
RHEA:13993	skos:altLabel	"L-3-aminoisobutyric aminotransferase"
RHEA:13993	skos:altLabel	"L-AIBAT"
REACT:R-HSA-374696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by p90rsk (Homo sapiens)
EC:3.4.16.6	skos:altLabel	"carboxypeptidase KEX1"
EC:3.4.16.6	skos:altLabel	"carboxypeptidase S1"
EC:3.4.16.6	skos:prefLabel	"carboxypeptidase D"
EC:3.4.16.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxypeptidase D"
RHEA:56104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 = 4,4'-diaponeurosporenal + 2 A + 3 H2O
RHEA:56950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phosphoenolpyruvate + UDP => pyruvate + UTP
GO:0061899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinal 3,4-desaturase activity
REACT:R-MMU-8865237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD6 methylates RELA in the NFkB complex (Mus musculus)
REACT:R-XTR-212614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamine transport from astrocytes (Xenopus tropicalis)
REACT:R-XTR-193696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Xenopus tropicalis)
RHEA:43858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in)
REACT:R-HSA-750993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (q) reassociates with G beta:gamma (Homo sapiens)
REACT:R-CFA-508369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Canis familiaris)
RHEA:35971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase"
RHEA:35971	skos:prefLabel	"12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase"
RHEA:35971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate = diphosphate + fumitremorgin B
REACT:R-RNO-9706304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to GRAP2 (Rattus norvegicus)
REACT:R-XTR-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Xenopus tropicalis)
REACT:R-GGA-2750187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Gallus gallus)
RHEA:48587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin A4
REACT:R-DRE-196773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COASY phosphorylates DP-CoA (Danio rerio)
REACT:R-GGA-982807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylation of GHR (Gallus gallus)
EC:4.8.-.-	skos:prefLabel	"Nitrogen-oxygen lyases"
EC:4.8.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Nitrogen-oxygen lyases"
RHEA:32544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => 1,8-cineole + diphosphate
REACT:R-HSA-1839112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT5 by cytosolic FGFR1 fusions (Homo sapiens)
RHEA:47064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SCE-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Saccharomyces cerevisiae)
RHEA:62978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + NH4(+) => (9Z,12Z,15Z)-octadecatrienamide + H2O
GO:0106301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0106301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonic acid 5,6-epoxygenase activity
RHEA:17824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen cyanide + L-cysteine <=> 3-cyano-L-alanine + H(+) + hydrogen sulfide
RHEA:69985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SCE-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Saccharomyces cerevisiae)
RHEA:44884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)
REACT:R-MMU-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Mus musculus)
REACT:R-HSA-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Homo sapiens)
REACT:R-HSA-3878762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver) (Homo sapiens)
REACT:R-BTA-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Bos taurus)
REACT:R-BTA-1614605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Persulfide sulfur is dioxygenated (Bos taurus)
REACT:R-MMU-192331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)
RHEA:53238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => desmosterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SSC-977071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Sus scrofa)
REACT:R-SSC-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Sus scrofa)
GO:0050003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxycytidylate C-methyltransferase"
GO:0050003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP = 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate
GO:0050003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity
GO:0050003	skos:prefLabel	"deoxycytidylate C-methyltransferase"
GO:0050003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidylate C-methyltransferase activity
GO:0050003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidylate methyltransferase activity
GO:0050003	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dCMP methyltransferase activity
RHEA:15840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + methylamine <=> N-methyl-L-glutamate + NH4(+)
RHEA:62099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-glycerol + phosphate
RHEA:18197	skos:prefLabel	"cyclohexyl-isocyanide hydratase"
RHEA:18197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexyl-isocyanide hydratase"
RHEA:18197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-cyclohexylformamide = cyclohexyl isocyanide + H2O
RHEA:18197	skos:altLabel	"isonitrile hydratase"
RHEA:68650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + L-lanthionine => 2 L-cysteine
REACT:R-CEL-5663050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHI and DHICA polymerise forming eumelanin (Caenorhabditis elegans)
RHEA:39616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O
RHEA:20816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha-hydroxyglycyrrhetinate dehydrogenase"
RHEA:20816	skos:prefLabel	"3alpha-hydroxyglycyrrhetinate dehydrogenase"
RHEA:20816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH
REACT:R-MMU-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Mus musculus)
GO:0032089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACHT domain binding
RHEA:31662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine
RHEA:19114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-heptadecatrienal + A + H2O => (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)
REACT:R-DDI-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Dictyostelium discoideum)
RHEA:58563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate II + NADP(+) <=> 15alpha-stemmadenine intermediate I + NADPH
REACT:R-CEL-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)
RHEA:40808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine
RHEA:51905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate
REACT:R-DRE-9018754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs bind RHOH (Danio rerio)
REACT:R-RNO-70592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Rattus norvegicus)
RHEA:10905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A => AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide
REACT:R-BTA-2161613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Bos taurus)
REACT:R-MMU-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Mus musculus)
REACT:R-GGA-372843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A10 mediates exchange of malate and phosphate (Gallus gallus)
RHEA:66185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP(in) + ATP + H2O => 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate
REACT:R-HSA-5623519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP and RAB8A bind to the ciliary targeting complex (Homo sapiens)
REACT:R-RNO-376851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Rattus norvegicus)
REACT:R-CFA-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Canis familiaris)
REACT:R-BTA-381543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP4 binds IGF forming IGF:IGFBP4 (Bos taurus)
RHEA:55938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-hydroxyretinal + H(+) + NADH => all-trans-4-hydroxyretinol + NAD(+)
REACT:R-SSC-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Sus scrofa)
RHEA:69613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + D-glucose => H2O + kojibiose
RHEA:36778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-CEL-9759549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Caenorhabditis elegans)
REACT:R-HSA-2172666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds condensin II (Homo sapiens)
REACT:R-DRE-4551724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 (Danio rerio)
RHEA:25581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-fucose => beta-L-fucose
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endodeoxyribonuclease I
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA depolymerase activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pancreatic deoxyribonuclease
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonuclease I activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkaline deoxyribonuclease activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA nuclease activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thymonuclease, dornase activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pancreatic DNase activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dornavac
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dornava
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pancreatic dornase
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thymonuclease activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA endonuclease activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNase activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkaline DNase activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	deoxyribonuclease (pancreatic)
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNAase activity
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Escherichia coli endonuclease I
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonuclease A
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNase I
GO:0004530	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic phosphatase activity
REACT:R-SSC-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Sus scrofa)
REACT:R-CEL-444654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled bile acid receptor binds lithocholic acid (Caenorhabditis elegans)
RHEA:21495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + H(+) <=> catechol + CO2
RHEA:24086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:24986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin] => (1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-DRE-73912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Danio rerio)
REACT:R-RNO-70369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Rattus norvegicus)
REACT:R-XTR-8855062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Xenopus tropicalis)
RHEA:32460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine
REACT:R-HSA-1222412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lpdC dimer reactivates dlaT (Homo sapiens)
REACT:R-RNO-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Rattus norvegicus)
RHEA:65364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
REACT:R-CFA-8854222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D3 associates with RAB5 (Canis familiaris)
REACT:R-MMU-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Mus musculus)
RHEA:65256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + verruculide C = A + H2O + verruculide C epoxide
REACT:R-BTA-9691566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 binds nicorandil (Bos taurus)
RHEA:36000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-BTA-6810410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)
RHEA:59363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine + H2O <=> beta-alanine + L-histidine
RHEA:16782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + H2O => a fatty acid + CoA + H(+)
REACT:R-XTR-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Xenopus tropicalis)
REACT:R-BTA-8940554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2 cleaves OPTC (Bos taurus)
REACT:R-BTA-5690759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Bos taurus)
RHEA:28646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> alpha-zingiberene + diphosphate
REACT:R-GGA-217097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Rad17-RFC alternate clamp-loader complex (Gallus gallus)
REACT:R-RNO-177479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Axonal transport of NGF:Trk complexes (Rattus norvegicus)
REACT:R-SSC-200718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Sus scrofa)
REACT:R-XTR-391905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxoeicosanoid receptor can bind oxoeicosanoid (Xenopus tropicalis)
REACT:R-HSA-4551683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOPORS with SUMO1 (Homo sapiens)
REACT:R-GGA-6811428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 recruits RAB6:GDP to the TGN (Gallus gallus)
REACT:R-SSC-170964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 binds to active TrkA receptor (Sus scrofa)
RHEA:55153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]
REACT:R-HSA-6807866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the ERGIC (Homo sapiens)
RHEA:49136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionyl-[protein] + NADPH + O2 = H2O + L-methionyl-S-oxide-[protein] + NADP(+)
RHEA:39362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)
RHEA:19062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nitrite => H(+) + NADPH + nitrate
RHEA:38465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CoA => a 1-acyl-sn-glycerol + an acyl-CoA
GO:0140560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylosyl alpha-1,3-xylosyltransferase activity
REACT:R-MMU-1562640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LNK binds to p-KIT and inhibit downstream signaling (Mus musculus)
RHEA:57406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + noscapine => NAD(+) + narcotine hemiacetal
RHEA:54038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycoredoxin]-S-mycothiol-L-cysteine + arsenite => [mycoredoxin]-L-cysteine + arseno-mycothiol + H(+)
REACT:R-DDI-8950522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1:p-STAT4 translocates to the nucleus (Dictyostelium discoideum)
RHEA:67907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + H(+) + malonyl-[ACP] <=> 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA
GO:0031691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1A adrenergic receptor binding
GO:0031691	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	alpha-1A adrenergic receptor ligand
REACT:R-XTR-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Xenopus tropicalis)
RHEA:10384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate = beta-cyclopiazonate + diphosphate
REACT:R-GGA-8858498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SL (surrogate light chain) binds IgH to form pre-BCR (Gallus gallus)
REACT:R-DME-3364014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SET1 methyltransferase complex (Drosophila melanogaster)
REACT:R-GGA-266315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + spherical HDL <=> LCAT:spherical HDL complex (Gallus gallus)
GO:0098750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYXD domain binding
REACT:R-CEL-158893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Caenorhabditis elegans)
REACT:R-CEL-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Caenorhabditis elegans)
RHEA:40498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 <=> N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine
RHEA:67922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in)
REACT:R-XTR-381713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Potassium voltage-gated channels close in reponse to PKA (Xenopus tropicalis)
REACT:R-MMU-3341343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Mus musculus)
GO:0052869	skos:altLabel	"omega-hydroxylase"
GO:0052869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + octane + 2 reduced [rubredoxin] = H2O + octan-1-ol + 2 oxidized [rubredoxin]
GO:0052869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonic acid omega-hydroxylase activity
GO:0052869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alkane 1-monooxygenase"
GO:0052869	skos:altLabel	"alkane 1-hydroxylase"
GO:0052869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arachidonic acid:oxygen 1-oxidoreductase activity
GO:0052869	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arachidonic acid hydroxylase activity
GO:0052869	skos:prefLabel	"alkane 1-monooxygenase"
GO:0052869	skos:altLabel	"lauric acid omega-hydroxylase"
GO:0052869	skos:altLabel	"fatty acid omega-hydroxylase"
REACT:R-SPO-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Schizosaccharomyces pombe)
REACT:R-MMU-391155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRPA binds SFTPA oligomer, SFTPD oligomer (Mus musculus)
REACT:R-HSA-8869566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The MYBL2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)
RHEA:47927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate <=> (2S)-3-sulfolactaldehyde + pyruvate
REACT:R-DRE-4546385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO2 (Danio rerio)
REACT:R-SSC-5654149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates PLCG1 (Sus scrofa)
RHEA:13805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 3-oxo-5alpha-steroid = a 3-oxo-Delta(4)-steroid + AH2
REACT:R-DME-2029460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 phosphorylates LIMK1 (Drosophila melanogaster)
RHEA:49859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:45900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA
RHEA:67913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O => 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid
REACT:R-HSA-74255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Guanine + H2O => Xanthine + NH4+ (Homo sapiens)
REACT:R-BTA-391935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP1 receptor can bind PGD2 (Bos taurus)
GO:1901681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur molecular entity binding
GO:1901681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur compound binding
RHEA:12583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + tauropine <=> H(+) + NADH + pyruvate + taurine
REACT:R-SSC-6810937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lamellar bodies bind the early cornified envelope (Sus scrofa)
REACT:R-GGA-5607723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Gallus gallus)
RHEA:59670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellohexaono-1,5-lactone + H2O2 => D-cellohexaose + O2
REACT:R-XTR-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Xenopus tropicalis)
REACT:R-CFA-2065550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds Importin beta-1 (Canis familiaris)
RHEA:44507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + an all-trans-polyprenyl diphosphate <=> a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate
REACT:R-SSC-5655835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Sus scrofa)
REACT:R-MMU-5324632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Mus musculus)
REACT:R-MMU-111285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)
RHEA:58142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetyl-AMP + cytidine(34) in elongator tRNA(Met)
RHEA:37571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
RHEA:46289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-DRE-2993763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Danio rerio)
RHEA:52236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin b
RHEA:17135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase] => ATP + L-seryl-[tyrosine-3-monooxygenase]
REACT:R-DME-5654705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
RHEA:41304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + dodecanoate
REACT:R-GGA-5432814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR2:TLR1 (Gallus gallus)
RHEA:47076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-6-phosphogluconic aldolase activity
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-dehydro-3-deoxygluconate aldolase activity
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ODPG aldolase activity
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydro-3-deoxy-phosphogluconate aldolase"
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygluconate-6-P-aldolase activity
GO:0008675	skos:altLabel	"2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase"
GO:0008675	skos:altLabel	"KDPG-aldolase"
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-keto-3-deoxygluconate aldolase activity
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-phosphogluconate aldolase activity
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KDPG aldolase activity
GO:0008675	skos:prefLabel	"2-dehydro-3-deoxy-phosphogluconate aldolase"
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	KDPG-aldolase activity
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-3-deoxy-6-phosphogluconate aldolase activity
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-2-keto-3-deoxygluconate aldolase activity
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-keto-3-deoxygluconic aldolase activity
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-6-phosphogluconate aldolase activity
GO:0008675	skos:altLabel	"phospho-2-dehydro-3-deoxygluconate aldolase"
GO:0008675	skos:altLabel	"2-keto-3-deoxy-6-phosphogluconate aldolase"
GO:0008675	skos:altLabel	"phospho-2-keto-3-deoxygluconate aldolase"
GO:0008675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxygluconate-6-phosphate aldolase activity
REACT:R-DRE-139855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X1-mediated entry of Ca++ from plasma (Danio rerio)
RHEA:68680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) = 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
RHEA:49957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine 1-carboxylate + O2 => H2O2 + phenazine-1-carboxylate
RHEA:45793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 => [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate
RHEA:60122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine => (2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine
REACT:R-HSA-982775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone receptor dimerizes (Homo sapiens)
REACT:R-BTA-390846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D2D3,4 bind to DA (Bos taurus)
GO:0043723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity
GO:0043723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRAP deaminase activity
GO:0043723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity
REACT:R-DME-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Drosophila melanogaster)
REACT:R-XTR-500708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRIK3 homomer binds glutamate (Xenopus tropicalis)
REACT:R-DRE-977363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3bBb (Danio rerio)
REACT:R-SSC-77321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Sus scrofa)
RHEA:60083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)
REACT:R-BTA-8938431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 and BTN1A1 binds periplakin (PPL) (Bos taurus)
REACT:R-DRE-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Danio rerio)
REACT:R-SCE-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Saccharomyces cerevisiae)
RHEA:61671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + salicylate <=> 2-hydroxybenzoyl-CoA + AMP + diphosphate
RHEA:39373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH
REACT:R-RNO-6806674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Rattus norvegicus)
GO:0044654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	starch alpha-glucosidase activity
GO:0044654	skos:prefLabel	"Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds"
GO:0044654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds"
REACT:R-HSA-5624125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the BBSome (Homo sapiens)
REACT:R-XTR-983700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds the activated BCR (Xenopus tropicalis)
REACT:R-HSA-3209177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERF binds ETS2 promoter (Homo sapiens)
REACT:R-CFA-5654659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
RHEA:55920	skos:altLabel	"heme-dependent rubber oxygenase"
RHEA:55920	skos:prefLabel	"exo-cleaving rubber dioxygenase"
RHEA:55920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exo-cleaving rubber dioxygenase"
RHEA:55920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[cis-1,4-isoprene](n) + O2 = (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)
REACT:R-HSA-6782224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
RHEA:52972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]
RHEA:53906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-threonyl-[tau protein] => ATP + L-threonyl-[tau protein]
REACT:R-BTA-450580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 (hnRNP D0) is ubiquitinylated (Bos taurus)
RHEA:62347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate <=> diphosphate + notoamide S
REACT:R-BTA-9706315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SH2B3 (Bos taurus)
REACT:R-CEL-8938913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ELF1 (Caenorhabditis elegans)
REACT:R-SSC-383373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 3 (NK3) binds to neurokinin B (Sus scrofa)
EC:3.4.21.77	skos:prefLabel	"semenogelase"
EC:3.4.21.77	skos:altLabel	"gamma-seminoprotein"
EC:3.4.21.77	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"semenogelase"
EC:3.4.21.77	skos:altLabel	"P-30 antigen"
EC:3.4.21.77	skos:altLabel	"prostate-specific antigen"
EC:3.4.21.77	skos:altLabel	"seminin"
REACT:R-HSA-5693602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM recognizes H2AFX-Nucleosomes (Homo sapiens)
GO:0004849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine kinase activity
GO:0004849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine kinase reaction
GO:0004849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine ribonucleoside kinase activity
GO:0004849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine kinase (phosphorylating)
GO:0004849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:uridine 5'-phosphotransferase activity
GO:0004849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine-cytidine kinase activity
GO:0004849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine monophosphokinase activity
GO:0004849	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine phosphokinase activity
RHEA:29624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltopentaose + beta-maltose => alpha-maltohexaose + beta-D-glucose
RHEA:24326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+) => 6-oxocineole + H(+) + NADPH + O2
RHEA:44845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + eicosanoyl-CoA => CoA + O-eicosanoyl-(R)-carnitine
REACT:R-DDI-9664881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)
REACT:R-HSA-8944650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-214 microRNA binds PTEN mRNA (Homo sapiens)
REACT:R-HSA-444419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium effflux out of kidney collecting duct cells (Homo sapiens)
REACT:R-RNO-4085217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Rattus norvegicus)
REACT:R-DDI-9033485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Dictyostelium discoideum)
RHEA:56462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-MMU-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Mus musculus)
REACT:R-CFA-70906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)
RHEA:31067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-2-oxohexanoate = Delta(1)-piperideine-2-carboxylate + H2O
REACT:R-BTA-196929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLAD1 phosphorylates FMN (Bos taurus)
REACT:R-XTR-2213205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type XII and XIV collagens associate with type I and type II fibrils. (Xenopus tropicalis)
REACT:R-DME-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Drosophila melanogaster)
REACT:R-SSC-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Sus scrofa)
RHEA:12899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-2430535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL phosphorylates ENSA (Canis familiaris)
REACT:R-DME-5693751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH2 hydrolyses AEA to AA and ETA (Drosophila melanogaster)
RHEA:15623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose
REACT:R-DME-8853710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MANBA hydrolyses GlcNAc:Man (Drosophila melanogaster)
RHEA:20886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypyruvate + H(+) + NADH + NH4(+) => H2O + L-serine + NAD(+)
RHEA:55309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
RHEA:16476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1,3-dione + H2O <=> 5-oxohexanoate + H(+)
RHEA:15760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine + NAD(+) <=> H(+) + L-aspartate 4-semialdehyde + NADH
RHEA:49273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] => calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5675194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPK phosphorylates RAF1 (Danio rerio)
RHEA:31479	skos:prefLabel	"soyasapogenol glucuronosyltransferase"
RHEA:31479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"soyasapogenol glucuronosyltransferase"
RHEA:31479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol A + UDP-alpha-D-glucuronate = H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP
REACT:R-HSA-448702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-1 active tetramer formation (Homo sapiens)
RHEA:45440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate
GO:0008713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A
GO:0008713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-heptose-lipopolysaccharide heptosyltransferase activity
GO:0008713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-heptose:LPS heptosyltransferase activity
REACT:R-CFA-6806647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Canis familiaris)
REACT:R-BTA-380949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK is dephosphorylated (Bos taurus)
REACT:R-GGA-162797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Gallus gallus)
REACT:R-MMU-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Mus musculus)
REACT:R-XTR-6801687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Xenopus tropicalis)
RHEA:43700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine
RHEA:43700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine
RHEA:43700	skos:prefLabel	"juvenile hormone-III synthase"
RHEA:43700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"juvenile hormone-III synthase"
RHEA:43700	skos:altLabel	"farnesoic acid methyltransferase"
RHEA:43700	skos:altLabel	"juvenile hormone acid methyltransferase"
REACT:R-RNO-2187332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic CMs translocate to extracellular region (Rattus norvegicus)
RHEA:19504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanoate + H2O <=> 4-aminobutanoate + urea
REACT:R-HSA-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Homo sapiens)
REACT:R-SPO-194642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Schizosaccharomyces pombe)
REACT:R-DDI-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Dictyostelium discoideum)
REACT:R-RNO-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Rattus norvegicus)
REACT:R-MMU-8855259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR:DAB1 binds SH3KBP1 (Mus musculus)
REACT:R-RNO-76054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Rattus norvegicus)
REACT:R-BTA-9732629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARG binds PPARG agonists (Bos taurus)
RHEA:18787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + gibberellin A12 + H(+) => A + gibberellin A12 aldehyde + H2O
RHEA:57997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh2 + H(+) + UDP
REACT:R-SSC-193781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Sus scrofa)
RHEA:11499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + uracil <=> 3-(uracil-1-yl)-L-alanine + acetate + H(+)
REACT:R-MMU-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Mus musculus)
RHEA:54631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dodecanoyl-CoA + O2 <=> 2-hydroxydodecanoyl-CoA + CO2 + succinate
REACT:R-MMU-5654628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS3 (Mus musculus)
RHEA:10775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O <=> D-glucose + D-glucose 6-phosphate
RHEA:21545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + ATP => (2E,6E)-farnesyl triphosphate + ADP
REACT:R-HSA-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Homo sapiens)
REACT:R-BTA-5246478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOM binds retinoids (Bos taurus)
RHEA:33829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin D2 => ergosterol
RHEA:26477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-L-rhamnose + phosphate <=> alpha-D-galactose 1-phosphate + L-rhamnopyranose
REACT:R-XTR-870477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Xenopus tropicalis)
REACT:R-MMU-8955844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBKS phosphorylates ribose to R5P (Mus musculus)
RHEA:36501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH => 2-dehydro-3-deoxy-L-rhamnonate + NAD(+)
REACT:R-MMU-1169397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ISG15 by UBA7 E1 ligase (Mus musculus)
REACT:R-CFA-212269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Canis familiaris)
REACT:R-SSC-9725206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds FCERI (Sus scrofa)
RHEA:46650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + propanoyl-CoA => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA
REACT:R-BTA-1296127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of voltage gated Potassium channels (Bos taurus)
RHEA:72966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(out) + 2 Na(+)(out) <=> acetoacetate(in) + 2 Na(+)(in)
RHEA:37187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-HSA-2066781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Homo sapiens)
REACT:R-CEL-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Caenorhabditis elegans)
RHEA:44190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate
REACT:R-GGA-9640254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Gallus gallus)
REACT:R-BTA-77608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of A1CF to stem-looped RNA (Bos taurus)
REACT:R-CFA-182990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty sequesters CBL away from active EGFR (Canis familiaris)
RHEA:23937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-gluconate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH
REACT:R-PFA-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Plasmodium falciparum)
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	insulin reductase activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-disulfide reductase (glutathione) activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:protein-disulfide oxidoreductase activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GSH-insulin transhydrogenase activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiol:protein-disulfide oxidoreductase activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione--insulin transhydrogenase activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-disulfide isomerase/oxidoreductase activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein disulfide transhydrogenase activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein disulfide reductase (glutathione)
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, protein disulfide (glutathione)
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiol-protein disulphide oxidoreductase activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione-protein disulfide oxidoreductase activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-disulphide reductase (glutathione) activity
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaredoxin reductase
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-disulfide interchange enzyme
GO:0019153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione-insulin transhydrogenase activity
REACT:R-CEL-2162225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from small HA fragments (Caenorhabditis elegans)
RHEA:58194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrobisanhydrobacterioruberin + diphosphate => dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin
REACT:R-DRE-176588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + PAPS => lithocholate sulfate + PAP (Danio rerio)
REACT:R-RNO-5250210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Rattus norvegicus)
REACT:R-SSC-75886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Sus scrofa)
REACT:R-BTA-9732527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds rosiglitazone (Bos taurus)
REACT:R-BTA-264834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis and degradation of apoA-I (Bos taurus)
REACT:R-GGA-158419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Gallus gallus)
REACT:R-XTR-9011595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Xenopus tropicalis)
RHEA:12962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + butanoyl-CoA => acetoacetyl-CoA + butanoate
RHEA:43459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0140869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miRNA inhibitor activity
GO:0140869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miRNA binding involved in posttranscriptional gene silencing
GO:0140869	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	miRNA base-pairing repressor activity
REACT:R-HSA-8853774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Homo sapiens)
REACT:R-GGA-6813659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE, CTSG or PRTN3 binds bacteria (Gallus gallus)
REACT:R-SCE-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Saccharomyces cerevisiae)
REACT:R-DME-2424246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind lecticans (Drosophila melanogaster)
RHEA:68786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + gamma-curcumene => (2Z,6Z)-farnesyl diphosphate
REACT:R-CFA-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Canis familiaris)
REACT:R-CFA-209821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of N-acetyl-5-HT to form melatonin (Canis familiaris)
REACT:R-RNO-1028816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Rattus norvegicus)
REACT:R-SSC-9674529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds to TBXA2R (Sus scrofa)
RHEA:12652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnofuranose + NAD(+) <=> H(+) + L-rhamnono-1,4-lactone + NADH
RHEA:20505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-glutamylcyclotransferase"
RHEA:20505	skos:prefLabel	"gamma-glutamylcyclotransferase"
RHEA:20505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid
RHEA:20505	skos:altLabel	"GGCT"
REACT:R-HSA-1791112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HDGF (Homo sapiens)
RHEA:29899	skos:altLabel	"D-xylose transporting ATPase"
RHEA:29899	skos:prefLabel	"ABC-type D-xylose/L-arabinose transporter"
RHEA:29899	skos:prefLabel	"ABC-type D-xylose transporter"
RHEA:29899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type D-xylose/L-arabinose transporter"
RHEA:29899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type D-xylose transporter"
RHEA:29899	skos:altLabel	"D-xylose ABC transporter"
RHEA:29899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-xylose(out) + H2O = ADP + D-xylose(in) + H(+) + phosphate
REACT:R-SSC-8852362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds CDKN1A (Sus scrofa)
RHEA:38006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate
RHEA:29032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + 2 Na(+)(in) => L-glutamate(out) + 2 Na(+)(out)
RHEA:50983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E1(out) <=> prostaglandin E1(in)
REACT:R-RNO-199203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK1/3/4 phosphorylate PanK (Rattus norvegicus)
REACT:R-XTR-420591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-2:Nectin 3 trans heterodimer interaction (Xenopus tropicalis)
REACT:R-MMU-5687121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPKAPK5 phosphorylates HSPB1 (Mus musculus)
RHEA:28956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucuronate(in) + H(+)(in) => aldehydo-D-glucuronate(out) + H(+)(out)
REACT:R-GGA-8851619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNT3 transfers GalNAc to FGF23 (Gallus gallus)
REACT:R-HSA-9761843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent GSR gene expression (Homo sapiens)
REACT:R-RNO-2160931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of tight junctions (Rattus norvegicus)
REACT:R-HSA-3149432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of VPU to Plasma Membrane (Homo sapiens)
REACT:R-BTA-450592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSRP binds AU-rich element in 3' UTR of mRNA (Bos taurus)
REACT:R-MMU-8934465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds PTPN12 (Mus musculus)
RHEA:66799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:67918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + NH4(+) => adenosine 5'-phosphoramidate + H2O
REACT:R-DME-9011543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCA binds PDK2 (Drosophila melanogaster)
RHEA:69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-2-butenoate + L-lysyl-[protein]
REACT:R-BTA-6781905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZRANB1 binds APC (Bos taurus)
RHEA:15137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol 1-phosphate + NAD(+) = H(+) + keto-L-tagatose 6-phosphate + NADH
REACT:R-MMU-1028820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of VAF (virus-activated factor) complex (Mus musculus)
REACT:R-HSA-5655233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)
RHEA:62292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2
REACT:R-GGA-9006850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor JAK phosphorylation (Gallus gallus)
REACT:R-XTR-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Xenopus tropicalis)
REACT:R-CFA-5649705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)
REACT:R-DDI-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Dictyostelium discoideum)
REACT:R-HSA-6788975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide anion dismutates to H2O2 (Homo sapiens)
REACT:R-HSA-380224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)
REACT:R-MMU-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Mus musculus)
REACT:R-DRE-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Danio rerio)
REACT:R-MMU-199206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Mus musculus)
RHEA:31302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + perillyl aldehyde <=> 2 H(+) + NADH + perillate
RHEA:61453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + oxytetracycline => 11a-hydroxy-oxytetracycline + H2O + NADP(+)
REACT:R-SSC-5666070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Sus scrofa)
GO:0140810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H1-R54 citrullination
GO:0140810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H1R54 arginine deiminase activity
GO:0140810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H1-R54 deiminase activity
GO:0140810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine deiminase activity (H1-R54 specific)
REACT:R-BTA-8875071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSS3 ligates CoA to CH3COO- (Bos taurus)
REACT:R-CFA-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Canis familiaris)
REACT:R-RNO-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Rattus norvegicus)
GO:0032810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol response element binding
GO:0032810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRE binding
RHEA:50995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thromboxane B2(out) <=> thromboxane B2(in)
RHEA:63287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-HSA-9622572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter (Homo sapiens)
REACT:R-DDI-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Dictyostelium discoideum)
REACT:R-HSA-8858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF9 binds TNFRSF9 (Homo sapiens)
RHEA:58211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydroalstonine <=> AH2 + alstonine
RHEA:72152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + glutarate(in) => estrone 3-sulfate(in) + glutarate(out)
REACT:R-HSA-197187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACS transforms to QUIN non-enzymatically (Homo sapiens)
RHEA:32182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-dihydrodipicolinate + NAD(+) <=> dipicolinate + H(+) + NADH
RHEA:31774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an all-trans-retinyl ester + H2O <=> 11-cis-retinol + a fatty acid + H(+)
REACT:R-SSC-6790487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 ubiquitinates SUMOylated XPC (Sus scrofa)
RHEA:22661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + ATP + holo-[ACP] => a fatty acyl-[ACP] + AMP + diphosphate
RHEA:65370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O
RHEA:68922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + NADP(+) + pentanal => ATP + H(+) + NADPH + pentanoate
GO:0015515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate:succinate antiporter activity
REACT:R-HSA-1226012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
REACT:R-CEL-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Caenorhabditis elegans)
RHEA:54877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3S)-3-isopropenyl-6-oxoheptanoate + H(+)
RHEA:13942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate + H(+)
REACT:R-MMU-9679775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT binds COMT Inhibitors (Mus musculus)
RHEA:27427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:24882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) = H(+) + L-glutamate + NADPH
RHEA:59243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + L-lysine <=> L-homoarginine + L-ornithine
RHEA:30636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
REACT:R-HSA-5652137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Damaged dsDNA becomes damaged DNA template (Homo sapiens)
REACT:R-DRE-2162193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHDB is methylated to MHDB by COQ3 (Danio rerio)
RHEA:63435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)
RHEA:48316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b = a ganglioside GD1alpha + CMP + H(+)
GO:0003944	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity
GO:0003944	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-acetylglucosaminyl phosphodiesterase activity
GO:0003944	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity
GO:0003944	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity
GO:0003944	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lysosomal alpha-N-acetylglucosaminidase activity
GO:0003944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
GO:0003944	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphodiester glycosidase activity
REACT:R-SSC-8980228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Sus scrofa)
RHEA:38146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon disulfide + 2 H2O <=> CO2 + 2 H(+) + 2 hydrogen sulfide
REACT:R-HSA-73800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAICAR => AICAR + Fumarate (Homo sapiens)
RHEA:52500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenedioyl-CoA + H2O2 => O2 + tetradecanedioyl-CoA
RHEA:32681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + diphosphate => (2E)-geranyl diphosphate + H2O
RHEA:60072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 = 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)
RHEA:50387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline <=> 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)
REACT:R-HSA-9691335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp7 binds nsp8 (Homo sapiens)
RHEA:71083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in) + 2 Na(+)(in)
GO:0060241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysozyme inhibitor activity
GO:0008774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde dehydrogenase (acetylating) activity
GO:0008774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADA
GO:0008774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylating acetaldehyde dehydrogenase activity
GO:0008774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde dehydrogenase (acylating) activity
GO:0008774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DmpF
GO:0008774	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)
REACT:R-RNO-5659781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 forms a heterodimer with BARD1 (Rattus norvegicus)
REACT:R-SCE-3781011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Saccharomyces cerevisiae)
REACT:R-SSC-3134800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING dimerization (Sus scrofa)
REACT:R-SSC-8865774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLLs polyglutamylate tubulin (Sus scrofa)
REACT:R-DME-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Drosophila melanogaster)
RHEA:51518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine
RHEA:31354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O
RHEA:50289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate
RHEA:59602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methoxyindoleacetaldehyde + H2O2 + NH4(+) => 5-methoxytryptamine + H2O + O2
REACT:R-HSA-8852509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL-LK binds carbohydrates on target cell surface (Homo sapiens)
REACT:R-CEL-6811504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)
REACT:R-PFA-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)
RHEA:59343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A <=> 1'-hydroxy-demethylspheroidene + AH2
GO:0110153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA NAD-cap (NMN-forming) hydrolase activity
GO:0110153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)
EC:1.14.19.38	skos:prefLabel	"acyl-lipid Delta(6)-acetylenase"
EC:1.14.19.38	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid Delta(6)-acetylenase"
REACT:R-XTR-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Xenopus tropicalis)
REACT:R-BTA-2586748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCA binds Ca2+ to form GUCA:Ca2+ (Bos taurus)
REACT:R-HSA-975865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)
REACT:R-CFA-429441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK activation by SRC (Canis familiaris)
RHEA:57086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O
RHEA:51629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) + UTP => CO2 + dUTP + H2O
RHEA:39908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose => dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate
REACT:R-GGA-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Gallus gallus)
REACT:R-CFA-6786110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL13-bound IL13R type II (Canis familiaris)
REACT:R-RNO-173725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C9 binds C5b:C6:C7:C8 (Rattus norvegicus)
RHEA:58153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + phosphonoacetaldehyde => 2 H(+) + NADH + phosphonoacetate
RHEA:19580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin + UDP-alpha-D-glucose <=> H(+) + luteolin 7-O-beta-D-glucoside + UDP
REACT:R-MMU-5362549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np traffics to the plasma membrane (Mus musculus)
RHEA:38837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine
REACT:R-BTA-8950453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Bos taurus)
GO:0018646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-2-oxolimonene 1,2-monooxygenase activity
REACT:R-DRE-350578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO1 interaction with ODC (Danio rerio)
REACT:R-XTR-9640175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Xenopus tropicalis)
RHEA:51936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(glutathione-S-yl)-hydroquinone + glutathione = glutathione disulfide + hydroquinone
RHEA:51936	skos:prefLabel	"glutathionyl-hydroquinone reductase"
RHEA:51936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathionyl-hydroquinone reductase"
REACT:R-PFA-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)
RHEA:41187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate
RHEA:52966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate
REACT:R-MMU-5654730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Mus musculus)
RHEA:15348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginine + L-tyrosine <=> AMP + diphosphate + H(+) + L-tyrosyl-L-arginine
REACT:R-RNO-9020273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Rattus norvegicus)
REACT:R-GGA-428909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-protein  G13 (Gallus gallus)
REACT:R-GGA-74723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosome acidification (Gallus gallus)
GO:0044686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteate synthase activity
RHEA:46657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADPH => 5beta-androstane-3,17-dione + NADP(+)
GO:0004911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-2 receptor activity
GO:0004911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-2 receptor activity
GO:0004911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-2R
RHEA:71168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(out) + H(+)(in) + Na(+)(out) => glycine(in) + H(+)(out) + Na(+)(in)
RHEA:14736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ag(+)(in) + ATP + H2O <=> ADP + Ag(+)(out) + H(+) + phosphate
REACT:R-MMU-9024881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Mus musculus)
RHEA:18786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + gibberellin A12 aldehyde + H2O => AH2 + gibberellin A12 + H(+)
REACT:R-CEL-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Caenorhabditis elegans)
REACT:R-XTR-8987255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Xenopus tropicalis)
RHEA:16088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
RHEA:34298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose <=> 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP
REACT:R-HSA-9619843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs phosphorylate RSKs (Homo sapiens)
REACT:R-XTR-71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Xenopus tropicalis)
REACT:R-DRE-202718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Danio rerio)
REACT:R-DME-350410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHO1:GDP complex dissociates from RHOGAPP190 (Drosophila melanogaster)
REACT:R-GGA-352956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+ (Gallus gallus)
REACT:R-SSC-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Sus scrofa)
RHEA:57371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH <=> (6R)-NADPHX
REACT:R-BTA-1236955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Movement of clathrin coated vesicles into early endosome (Bos taurus)
REACT:R-HSA-5246509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botC:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
REACT:R-RNO-5659861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)
RHEA:19156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose <=> 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP
REACT:R-SSC-6805109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates TP53 (Sus scrofa)
RHEA:72685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate(in) => cholate(out)
REACT:R-BTA-109860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 phosphorylates MAPK3 (Bos taurus)
REACT:R-XTR-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Xenopus tropicalis)
RHEA:18765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + a sphingomyelin
RHEA:18765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sphingomyelin synthase"
RHEA:18765	skos:prefLabel	"sphingomyelin synthase"
RHEA:18765	skos:altLabel	"phosphatidylcholine:ceramide cholinephosphotransferase"
RHEA:18765	skos:altLabel	"SM synthase"
EC:2.5.-.-	skos:prefLabel	"Transferring alkyl or aryl groups, other than methyl groups"
EC:2.5.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring alkyl or aryl groups, other than methyl groups"
REACT:R-DDI-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Dictyostelium discoideum)
GO:0102323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopropylphenol monooxygenase activity
REACT:R-RNO-5205661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is recruited from the cytoplasm to the mitochondria (Rattus norvegicus)
REACT:R-DRE-139920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tBID to mitochondria (Danio rerio)
RHEA:72816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)
RHEA:50756	skos:altLabel	"FPR"
RHEA:50756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + reduced [flavodoxin] = 2 H(+) + NADPH + oxidized [flavodoxin]
RHEA:50756	skos:prefLabel	"flavodoxin--NADP(+) reductase"
RHEA:50756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavodoxin--NADP(+) reductase"
REACT:R-DRE-372705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of BCAR1 to PTK2 complex (Danio rerio)
REACT:R-HSA-8948027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial phospholipids (Homo sapiens)
REACT:R-XTR-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Xenopus tropicalis)
REACT:R-MMU-3149519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC decyanates CNCbl (Mus musculus)
RHEA:55250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-5579023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA2(869-1464) binds KAT6A(1-1118) (Homo sapiens)
RHEA:51850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-methylmenaquinol-6 + fumarate => 8-methylmenaquinone-6 + succinate
REACT:R-GGA-430190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds NCK (Gallus gallus)
REACT:R-CFA-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Canis familiaris)
REACT:R-DRE-5607736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 oligomerizes (Danio rerio)
REACT:R-MMU-352364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Mus musculus)
REACT:R-MMU-193766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
REACT:R-RNO-2130731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of COPII vesicle (Rattus norvegicus)
REACT:R-DRE-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Danio rerio)
RHEA:50396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-heptyl-4(1H)-quinolone synthase"
RHEA:50396	skos:prefLabel	"2-heptyl-4(1H)-quinolone synthase"
RHEA:50396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA = 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O
REACT:R-MMU-6786190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMBL hydrolyses OM to OLMS (Mus musculus)
RHEA:58053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + acetyl-CoA => (2-acetamidoethyl)phosphonate + CoA + H(+)
REACT:R-GGA-1912369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH precursor cleaved to form mature NOTCH (Gallus gallus)
REACT:R-XTR-913451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL3RB is phosphorylated on Ser-585 (Xenopus tropicalis)
REACT:R-RNO-5682690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 dissociates from ATG12:ATG5 (Rattus norvegicus)
REACT:R-MMU-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Mus musculus)
REACT:R-CFA-202713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD84 homodimerises (Canis familiaris)
REACT:R-DME-8869506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Drosophila melanogaster)
RHEA:47287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Homo sapiens)
REACT:R-BTA-209061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Bos taurus)
RHEA:18502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosterol + NADP(+) => ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH
RHEA:30374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O <=> (-)-geosmin + acetone
REACT:R-MMU-399936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of integrin activation by sequestering PIP5KIgamma (Mus musculus)
RHEA:62722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone B + 3 H2O + 3 NADP(+) => 3 H(+) + 3 NADPH + 3 O2 + probetaenone I
RHEA:44524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)
REACT:R-BTA-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-CFA-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
REACT:R-MMU-111915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK4 autophosphorylates (Mus musculus)
REACT:R-CFA-77338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Canis familiaris)
REACT:R-DRE-77338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Danio rerio)
REACT:R-SPO-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Schizosaccharomyces pombe)
RHEA:47961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(tele)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate
RHEA:60882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O
REACT:R-DRE-193497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Danio rerio)
REACT:R-CEL-5694410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMED2:TMED10 tetramer binds GPI anchored proteins (Caenorhabditis elegans)
EC:2.3.1.258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-terminal methionine N(alpha)-acetyltransferase NatE"
EC:2.3.1.258	skos:prefLabel	"N-terminal methionine N(alpha)-acetyltransferase NatE"
GO:0015019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity
GO:0015019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan-alpha-glucosaminide N-acetyltransferase activity
GO:0015019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity
GO:0015019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin-alpha-glucosaminide N-acetyltransferase activity
RHEA:52825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)
RHEA:52018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA
REACT:R-XTR-174444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C-strand Okazaki fragments (Xenopus tropicalis)
REACT:R-DDI-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Dictyostelium discoideum)
RHEA:51722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out)
REACT:R-RNO-8857583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by PTK6 (Rattus norvegicus)
RHEA:50193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-DDI-389609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-2 oxidizes pristanal to pristanate (Dictyostelium discoideum)
REACT:R-HSA-211874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2S1 4-hydroxylates atRA (Homo sapiens)
REACT:R-DME-194698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Drosophila melanogaster)
REACT:R-CFA-977619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Canis familiaris)
RHEA:62853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
REACT:R-HSA-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Homo sapiens)
RHEA:31326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)
REACT:R-XTR-5637686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)
REACT:R-GGA-8952419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs ubiquitinate RUNX3 (Gallus gallus)
REACT:R-CFA-5662608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT2A binds cadmium (Canis familiaris)
REACT:R-BTA-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
EC:1.14.15.14	skos:prefLabel	"methyl-branched lipid omega-hydroxylase"
EC:1.14.15.14	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methyl-branched lipid omega-hydroxylase"
EC:1.14.15.14	skos:altLabel	"CYP124"
REACT:R-CEL-5623622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Caenorhabditis elegans)
RHEA:56934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-androst-5-en-3-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)
REACT:R-DRE-6784598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPPA(124-151) binds NPR1 (Danio rerio)
RHEA:61921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-ketoconazole(in) + ATP + H2O => (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate
RHEA:63692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol glucuronate acceptor + UDP-alpha-D-glucuronate = a beta-D-glucuronoside + H(+) + UDP
RHEA:21369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + urate => 5-hydroxyisourate + H2O2
REACT:R-RNO-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Rattus norvegicus)
REACT:R-XTR-8871227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA4 (Xenopus tropicalis)
RHEA:52955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + UDP-alpha-D-glucuronate <=> lithocholoyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-BTA-399933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sema3A binds Nrp-1 bound to PlexinA (Bos taurus)
REACT:R-CEL-3000335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Caenorhabditis elegans)
REACT:R-BTA-606287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSF complex binds the centromere (Bos taurus)
REACT:R-HSA-9031522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the APOE gene (Homo sapiens)
GO:0030782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydroprotoberberine cis-N-methyltransferase activity
GO:0030782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity
GO:0030782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-tetrahydroprotoberberine N-methyltransferase activity
RHEA:39312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)
EC:1.13.1.-	skos:prefLabel	"With NADH or NADPH as one donor"
EC:1.13.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NADH or NADPH as one donor"
RHEA:29525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose
REACT:R-BTA-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Bos taurus)
RHEA:58150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ethanol + H(+) => ethyl acetate + H2O
REACT:R-BTA-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Bos taurus)
REACT:R-MMU-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Mus musculus)
RHEA:47764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:40240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + dodecanedioate => AMP + diphosphate + dodecanedioyl-CoA
RHEA:37070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
REACT:R-BTA-8942099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Bos taurus)
REACT:R-SPO-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Schizosaccharomyces pombe)
REACT:R-DME-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Drosophila melanogaster)
REACT:R-DRE-9014627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDS dimers:PXLP dehydrate L-Thr to 2AA (Danio rerio)
RHEA:46706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybenzoyl-5'-AMP + diphosphate => ATP + H(+) + salicylate
RHEA:24626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr) => ATP + L-threonine + tRNA(Thr)
REACT:R-BTA-9029566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Bos taurus)
REACT:R-CFA-3000335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Canis familiaris)
RHEA:62321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-isomalbrancheamide B + FADH2
RHEA:58910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+) => 7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH
RHEA:19932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP
RHEA:67836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:41339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
REACT:R-DME-9717214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 binds ITPR3 tetramer (Drosophila melanogaster)
REACT:R-HSA-5684169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6B binds PTPN6,PTPN11 (Homo sapiens)
REACT:R-CFA-5419281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRRF binds 55S ribosome:mRNA:tRNA (Canis familiaris)
RHEA:61479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + octadecanoyl-CoA <=> an N-octadecanoyl-sphingoid base + CoA + H(+)
RHEA:60768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2-oxoglutarate + gibberellin A12 + 3 O2 = 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate
RHEA:17755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine => S-(5-deoxy-D-ribos-5-yl)-L-homocysteine
REACT:R-BTA-8952716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 binds Ragulator:Rag dimers (Bos taurus)
REACT:R-RNO-193816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Rattus norvegicus)
REACT:R-RNO-201631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 3 (Rattus norvegicus)
REACT:R-HSA-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Homo sapiens)
REACT:R-MMU-202168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ZAP-70 by Lck (Mus musculus)
REACT:R-DDI-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:63967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-4E,14Z-dienine-1-phosphate <=> (2E,12Z)-hexadecadienal + phosphoethanolamine
REACT:R-XTR-389897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Xenopus tropicalis)
REACT:R-CEL-1454757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Caenorhabditis elegans)
RHEA:49946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate
RHEA:69086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrylate + 2 H(+) + NADH => acrolein + H2O + NAD(+)
REACT:R-CFA-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Canis familiaris)
REACT:R-HSA-6785165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Homo sapiens)
REACT:R-HSA-9612445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STMN1 gene expression is stimulated by ERBB4s80 (Homo sapiens)
REACT:R-MMU-162798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Mus musculus)
RHEA:24766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
REACT:R-DDI-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Dictyostelium discoideum)
RHEA:51926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + beta-dihydromenaquinone-9 => AH2 + menaquinone-9
REACT:R-CEL-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Caenorhabditis elegans)
REACT:R-DME-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Drosophila melanogaster)
REACT:R-SSC-1358790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates ERBB3 (Sus scrofa)
REACT:R-HSA-1225950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)
REACT:R-DRE-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Danio rerio)
REACT:R-RNO-1678843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein translation regulator 4EHP (Rattus norvegicus)
REACT:R-XTR-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Xenopus tropicalis)
GO:0015112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate transmembrane transporter activity
GO:0015112	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite/nitrate porter activity
GO:0015112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(in) = nitrate(out)
RHEA:68915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + propanoate <=> AMP + diphosphate + NADP(+) + propanal
REACT:R-CFA-2454208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta and gamma subunits by LYN (Canis familiaris)
REACT:R-XTR-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Xenopus tropicalis)
REACT:R-HSA-2090043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(7) (Homo sapiens)
RHEA:27296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n) => D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-XTR-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Xenopus tropicalis)
REACT:R-DRE-5685953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates RBBP8 (Danio rerio)
REACT:R-CFA-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Canis familiaris)
RHEA:34698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> Delta(6)-protoilludene + diphosphate
REACT:R-DRE-429992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARN deadenylates mRNA (Danio rerio)
REACT:R-DME-188390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E:CDK2-mediated phosphorylation of RB1 (Drosophila melanogaster)
REACT:R-RNO-193143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates TEST to EST17b (Rattus norvegicus)
RHEA:48529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GP1c (d18:1(4E)) + H2O => ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate
RHEA:46332	skos:altLabel	"phosphatidylcholine desaturase"
RHEA:46332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid omega-6 desaturase (cytochrome b5)"
RHEA:46332	skos:altLabel	"linoleate synthase"
RHEA:46332	skos:altLabel	"oleate desaturase"
RHEA:46332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46332	skos:altLabel	"oleoyl-CoA desaturase"
RHEA:46332	skos:prefLabel	"acyl-lipid omega-6 desaturase (cytochrome b5)"
REACT:R-BTA-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Bos taurus)
REACT:R-GGA-8952044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Gallus gallus)
REACT:R-SSC-2396399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillins bind BMPs (Sus scrofa)
RHEA:18068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphonate(out) <=> ADP + H(+) + phosphate + phosphonate(in)
GO:0022883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc efflux transmembrane transporter activity
GO:0022883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc efflux permease activity
REACT:R-HSA-9796379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Homo sapiens)
RHEA:11913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) => 15-oxoprostaglandin E2 + H(+) + NADPH
REACT:R-DRE-5654428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates SHC1 (Danio rerio)
REACT:R-HSA-741395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD9 binds RIP2 (and NOD2) (Homo sapiens)
RHEA:58556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate II + H2O = (16S)-deshydroxymethyl-stemmadenine + formate
RHEA:18021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+)
RHEA:17136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[tyrosine-3-monooxygenase] <=> ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]
GO:0102872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-16:0-2-18:2-phosphatidylcholine desaturase activity
REACT:R-CEL-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Caenorhabditis elegans)
REACT:R-DDI-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Dictyostelium discoideum)
RHEA:10937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-decylubiquinone + 2 thiosulfate => 6-decylubiquinol + tetrathionate
EC:3.5.1.135	skos:prefLabel	"N(4)-acetylcytidine amidohydrolase"
EC:3.5.1.135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(4)-acetylcytidine amidohydrolase"
RHEA:42626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-aminoacrylate + CO2 + NH4(+) => (Z)-3-ureidoacrylate + H(+) + H2O
RHEA:29280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menaquinol-8 + trimethylamine N-oxide => H2O + menaquinone-8 + trimethylamine
RHEA:12528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP
GO:0043365	skos:altLabel	"[pyruvate formate-lyase]-activating enzyme"
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PFL activase activity
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[formate-C-acetyltransferase]-activating enzyme"
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate formate-lyase-activating enzyme
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate acetyltransferase activating enzyme activity
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[formate-C-acetyltransferase]-activating enzyme activity
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]
GO:0043365	skos:altLabel	"formate acetyltransferase activating enzyme"
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate-C-acetyltransferase-activating enzyme
GO:0043365	skos:altLabel	"PFL activase"
GO:0043365	skos:altLabel	"formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)"
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[pyruvate formate-lyase]-activating enzyme activity
GO:0043365	skos:prefLabel	"[formate-C-acetyltransferase]-activating enzyme"
GO:0043365	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity
GO:0043365	skos:altLabel	"pyruvate formate-lyase 1 activating enzyme"
GO:0043365	skos:altLabel	"PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving)"
RHEA:11623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-amino-4-chloropent-4-enoate <=> 2-oxopent-4-enoate + chloride + H(+) + NH4(+)
GO:0005223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular cGMP activated cation channel activity
GO:0005223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellular cGMP-activated cation channel activity
RHEA:71406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanyl-5'-AMP + diphosphate => ATP + D-alanine + H(+)
RHEA:38958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine 1-phosphate(in) <=> an N-acylsphing-4-enine 1-phosphate(out)
REACT:R-SSC-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Sus scrofa)
RHEA:57317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cytidine 5'-diphosphoramidate => ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)
REACT:R-DME-5653878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Drosophila melanogaster)
GO:0103042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-threonine aldolase activity
GO:0103042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-threonine = glycine + glycolaldehyde
REACT:R-MMU-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Mus musculus)
REACT:R-DME-6787321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DERA cleaves dR5P to GA3P and CH3CHO (Drosophila melanogaster)
REACT:R-HSA-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Homo sapiens)
GO:0030586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity
GO:0030586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
GO:0030586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[methionine synthase] reductase activity
GO:0030586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine synthase cob(II)alamin reductase (methylating) activity
GO:0030586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine synthase reductase activity
GO:0030586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity
GO:0030586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)
RHEA:55736	skos:prefLabel	"rhamnogalacturonan I rhamnosyltransferase"
RHEA:55736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rhamnogalacturonan I rhamnosyltransferase"
RHEA:55736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose = [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP
RHEA:55736	skos:altLabel	"RG I rhamnosyltransferase"
RHEA:20249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine = D-alanine
RHEA:20249	skos:prefLabel	"alanine racemase"
RHEA:20249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alanine racemase"
RHEA:44854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-(5Z)-tetradecenoyl-(R)-carnitine => (5Z)-tetradecenoyl-CoA + (R)-carnitine
REACT:R-CEL-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Caenorhabditis elegans)
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose dolichyl-phosphate glucosyltransferase activity
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:dolicholphosphoryl glucosyltransferase activity
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:dolichyl monophosphate glucosyltransferase activity
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-dolichol glucosyltransferase activity
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:dolichyl phosphate glucosyltransferase activity
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of dolichyl-phosphate-glucose (Homo sapiens)
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:dolichol phosphate glucosyltransferase activity
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-phosphate beta-glucosyltransferase activity
GO:0004581	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity
REACT:R-BTA-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Bos taurus)
RHEA:13916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine <=> D-threonine
RHEA:33522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine <=> (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-BTA-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Bos taurus)
RHEA:21248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
REACT:R-SSC-159790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)
RHEA:15662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside => an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA
REACT:R-CFA-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Canis familiaris)
RHEA:18972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + H(+) + hnu <=> a long-chain alkane + CO2
REACT:R-GGA-9012315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Gallus gallus)
REACT:R-DRE-2168883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin:Hemoglobin binds CD163 (Danio rerio)
REACT:R-HSA-8964614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Homo sapiens)
REACT:R-RNO-1237059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ dehydrates HCO3- to CO2 (Rattus norvegicus)
REACT:R-MMU-8950731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:IL27 translocates to the extracellular region (Mus musculus)
RHEA:61353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + riboflavin(in) => ADP + H(+) + phosphate + riboflavin(out)
REACT:R-DDI-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Dictyostelium discoideum)
REACT:R-RNO-389354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Vav1 (Rattus norvegicus)
RHEA:31115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin + H(+) = biotinyl-5'-AMP + diphosphate
REACT:R-HSA-2328048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Emilin is found in elastic fibres (Homo sapiens)
RHEA:52621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA => 2,2-dimethylpropanoyl-CoA
RHEA:15803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O
REACT:R-RNO-8849042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS3 (Rattus norvegicus)
RHEA:11757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin + L-lysyl-[protein] => AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]
EC:3.4.22.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"asclepain"
EC:3.4.22.7	skos:prefLabel	"asclepain"
RHEA:60093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => 3-dehydro-4alpha-methylzymosterol + CO2 + NADH
REACT:R-XTR-418200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 bound to ARRB2 is not activated (Xenopus tropicalis)
REACT:R-RNO-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Rattus norvegicus)
RHEA:36841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-BTA-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Bos taurus)
GO:0004139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribose-5-phosphate aldolase activity
GO:0004139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyriboaldolase activity
GO:0004139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)
GO:0004139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity
GO:0004139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphodeoxyriboaldolase activity
GO:0004139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-deoxyribose-5-phosphate aldolase activity
GO:0004139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribose-phosphate aldolase activity
RHEA:62761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-9625375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO3,FOXO4 bind STK11 gene promoter (Homo sapiens)
REACT:R-CFA-169904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3G stimulates nucleotide exchange on Rap1 (Canis familiaris)
REACT:R-GGA-195378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization of VEGF proteins (Gallus gallus)
REACT:R-DRE-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Danio rerio)
REACT:R-MMU-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Mus musculus)
REACT:R-MMU-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Mus musculus)
REACT:R-XTR-975389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Xenopus tropicalis)
GO:0008413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydro-8-oxoguanine-triphosphatase activity
GO:0008413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0008413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-7,8-dihydroguanosine triphosphatase activity
GO:0008413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-7,8-dihydroguanine triphosphatase activity
GO:0008413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GTPase activity
REACT:R-HSA-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)
RHEA:72645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine
REACT:R-DRE-1475022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)
RHEA:55472	skos:prefLabel	"syn-pimaradiene 3-monooxygenase"
RHEA:55472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"syn-pimaradiene 3-monooxygenase"
RHEA:55472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55472	skos:altLabel	"CYP701A8"
REACT:R-DRE-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Danio rerio)
REACT:R-SPO-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Schizosaccharomyces pombe)
RHEA:57188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein]
RHEA:33021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-6-acetamido-3-aminohexanoate + CoA + H(+) => (3S)-3,6-diaminohexanoate + acetyl-CoA
REACT:R-BTA-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Bos taurus)
RHEA:60670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemal + H(+) + NADH => (R,R)-chrysanthemol + NAD(+)
RHEA:60774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + gibberellin A9 + 2 H2O + 2 succinate => 2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2
REACT:R-DDI-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Dictyostelium discoideum)
REACT:R-MMU-8940388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPLD1 hydrolyses GPI-anchors from proteins (Mus musculus)
RHEA:59897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-propargylglycine => ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate
REACT:R-MMU-9681375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds ripretinib (Mus musculus)
REACT:R-RNO-5668481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protesomal degradation of K48polyUb-TRAF3 (Rattus norvegicus)
RHEA:72530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine
RHEA:69223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-glucosinolate + H2O <=> a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)
REACT:R-BTA-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Bos taurus)
RHEA:49089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + H2O + squalene => FADH2 + hydroxysqualene
RHEA:10485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-feruloylglycine => (E)-ferulate + glycine
REACT:R-DME-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Drosophila melanogaster)
RHEA:25535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate <=> diphosphate + ent-cassa-12,15-diene
REACT:R-SSC-8855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RELN:VLDLR binds DAB1 (Sus scrofa)
RHEA:67627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:48414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer + N-acetyl-alpha-D-galactosamine => globoside IV3GalNAc-Gb4Cer + H2O
REACT:R-BTA-5672843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1S1 (PRAS40) binds mTORC1 (Bos taurus)
REACT:R-HSA-164505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of full-length duplex viral DNA with a discontinuous plus strand (Homo sapiens)
REACT:R-RNO-517444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Rattus norvegicus)
REACT:R-DDI-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Dictyostelium discoideum)
RHEA:20533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal
RHEA:44098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + decanyl hexadecanoate => decan-1-ol + hexadecanoyl-CoA
RHEA:59522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate
REACT:R-RNO-4641249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Rattus norvegicus)
RHEA:13071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphoethanolamine => ATP + ethanolamine
RHEA:40202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-6806957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET receptor dimerizes (Homo sapiens)
REACT:R-CFA-114259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase‑9 to caspase‑9 (Canis familiaris)
RHEA:70042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Homo sapiens)
RHEA:69964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone
REACT:R-BTA-1306876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP3 activation by small molecules (Bos taurus)
REACT:R-MMU-428888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ROBO1 by ABL kinase (Mus musculus)
GO:0106319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-limonene 1,2-monooxygenase NADH activity
REACT:R-DRE-5690250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Danio rerio)
RHEA:57095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + S-(methylsulfanyl)glutathione <=> A + glutathione + methanethiol
REACT:R-BTA-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Bos taurus)
REACT:R-MMU-5618098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Mus musculus)
REACT:R-BTA-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Bos taurus)
REACT:R-HSA-9694549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)
REACT:R-HSA-1605595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Homo sapiens)
REACT:R-RNO-879221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSTPIP1 binds Pyrin (Rattus norvegicus)
REACT:R-CFA-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Canis familiaris)
RHEA:58609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-decanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine
RHEA:40370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)
GO:0001849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C1q complex binding
REACT:R-CFA-202168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ZAP-70 by Lck (Canis familiaris)
RHEA:44755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-8944266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XI (Danio rerio)
RHEA:41345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate
REACT:R-XTR-508308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Xenopus tropicalis)
REACT:R-HSA-452108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)
REACT:R-DME-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Drosophila melanogaster)
REACT:R-DRE-6788556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to NDUFV1, V2 (Danio rerio)
REACT:R-HSA-451311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca-permeable Kainate receptors (Homo sapiens)
REACT:R-MMU-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Mus musculus)
REACT:R-CFA-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Canis familiaris)
RHEA:29069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + menaquinol-8 => formate + H(+) + menaquinone-8
RHEA:41757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate
RHEA:45218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein]
RHEA:25250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 pyruvate => (2S)-2-acetolactate + CO2
REACT:R-HSA-1237325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A is protonated and carbamated causing release of oxygen (Homo sapiens)
REACT:R-DRE-109449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Danio rerio)
RHEA:69804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + benzoate + H(+) => benzoyl-AMP + diphosphate
REACT:R-CEL-72180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of mRNA at the 3'-end (Caenorhabditis elegans)
RHEA:21351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + 10 malonyl-CoA <=> 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2
REACT:R-GGA-9707504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 oxidises ferrohemoglobin to MetHb (Gallus gallus)
REACT:R-DRE-877187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates loss of intracellular K+ (Danio rerio)
RHEA:46707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + salicylate <=> 2-hydroxybenzoyl-5'-AMP + diphosphate
REACT:R-CFA-9627107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP7 (Canis familiaris)
REACT:R-XTR-8851797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 in ADRB2:GRK complex is phosphorylated (Xenopus tropicalis)
REACT:R-SSC-428909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-protein  G13 (Sus scrofa)
RHEA:29241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + uracil(out) => H(+)(in) + uracil(in)
EC:2.7.11.25	skos:altLabel	"MAP3K"
EC:2.7.11.25	skos:altLabel	"MLK-like mitogen-activated protein triple kinase"
EC:2.7.11.25	skos:altLabel	"MEK kinase"
EC:2.7.11.25	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mitogen-activated protein kinase kinase kinase"
EC:2.7.11.25	skos:altLabel	"MAPKKK"
EC:2.7.11.25	skos:altLabel	"MEKK"
EC:2.7.11.25	skos:altLabel	"MAP kinase kinase kinase"
EC:2.7.11.25	skos:prefLabel	"mitogen-activated protein kinase kinase kinase"
EC:2.7.11.25	skos:altLabel	"MLTK"
RHEA:12667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+) => a 2-deoxystreptamine antibiotic + acetyl-CoA
REACT:R-DME-9707690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 binds MAFK (Drosophila melanogaster)
REACT:R-CFA-389381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gads binds CD28 (Canis familiaris)
REACT:R-DME-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Drosophila melanogaster)
RHEA:10966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-xylulose 5-phosphate + H(+) => ATP + D-xylulose
REACT:R-XTR-3900194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates DDX5 with SUMO2 (Xenopus tropicalis)
RHEA:19510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 2 H(+) + L-erythro-biopterin + 2 NADPH
REACT:R-DRE-9709360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 reduces MetHb (Danio rerio)
REACT:R-HSA-5625745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1 stimulates association of AR with NCOA2 (Homo sapiens)
REACT:R-HSA-9621404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP51A1 gene expression (Homo sapiens)
REACT:R-MMU-193845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)
RHEA:67226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA => (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA
REACT:R-HSA-2671829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 Phosphorylates STAT5 in Response to Leptin (Homo sapiens)
RHEA:23508	skos:altLabel	"cephalosporin C acylase"
RHEA:23508	skos:altLabel	"GA"
RHEA:23508	skos:prefLabel	"glutaryl-7-aminocephalosporanic-acid acylase"
RHEA:23508	skos:altLabel	"GL-7-ACA acylase"
RHEA:23508	skos:altLabel	"glutaryl-7-ACA acylase"
RHEA:23508	skos:altLabel	"7beta-(4-carboxybutanamido)cephalosporanic acid acylase"
RHEA:23508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutaryl-7-aminocephalosporanic-acid acylase"
RHEA:23508	skos:altLabel	"glutaryl-7-aminocephalosporanic acid acylase"
RHEA:23508	skos:altLabel	"CA"
RHEA:23508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate
RHEA:23508	skos:altLabel	"cephalosporin acylase"
RHEA:23508	skos:altLabel	"GCA"
REACT:R-XTR-2127257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Xenopus tropicalis)
RHEA:54285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-octadecanoylsphing-4-enine + phosphocholine
REACT:R-GGA-418662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src activation following P2Y purinoceptor activation (Gallus gallus)
GO:0071814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-lipid complex binding
RHEA:59992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + phloretate = (E)-4-coumarate + reduced [electron-transfer flavoprotein]
RHEA:61040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + reduced [electron-transfer flavoprotein] => a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]
RHEA:14408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH
REACT:R-CFA-170686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)
REACT:R-DRE-212007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1 4-hydroxylate atRA (Danio rerio)
REACT:R-HSA-5696872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)
REACT:R-GGA-5624954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INPP5E translocates to the primary cilium (Gallus gallus)
GO:0042586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polypeptide deformylase activity
GO:0042586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyl-L-methionyl peptide amidohydrolase activity
GO:0042586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide deformylase activity
GO:0042586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDF activity
RHEA:36514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA
REACT:R-DRE-1433423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP-RO interacts with p-c-Kit complex (Danio rerio)
REACT:R-SCE-70482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ (Saccharomyces cerevisiae)
REACT:R-SSC-9029690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-6 translocates to the nucleus (Sus scrofa)
RHEA:55245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O
RHEA:71804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(out) + H(+)(out) => acetate(in) + H(+)(in)
RHEA:51814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out)
REACT:R-DRE-140664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Danio rerio)
REACT:R-MMU-191830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP nuclear import and release (Mus musculus)
REACT:R-BTA-8932275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Bos taurus)
REACT:R-RNO-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Rattus norvegicus)
REACT:R-HSA-399928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Rnd1 to Plexin A (Homo sapiens)
RHEA:26056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H(+) + valienol 1-phosphate => diphosphate + GDP-valienol
REACT:R-DME-352268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Satb1 (Drosophila melanogaster)
REACT:R-BTA-6797803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds SLITRK1-6 (Bos taurus)
REACT:R-CFA-69006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Cdc6 is exported from the nucleus (Canis familiaris)
REACT:R-CFA-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Canis familiaris)
RHEA:22544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
RHEA:48285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => globoside NOR1 (d18:1(4E)) + H(+) + UDP
RHEA:69663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + luteolin 7-O-beta-D-glucoside = beta-D-glucose + luteolin
RHEA:58766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH
RHEA:52392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-erythronate = 4-phospho-D-erythronate + ADP + H(+)
RHEA:52392	skos:prefLabel	"D-erythronate 4-kinase"
RHEA:52392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-erythronate 4-kinase"
GO:0080099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine:alpha-ketoglutarate aminotransferase activity
GO:0080099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine:2-oxoglutarate aminotransferase activity
REACT:R-SPO-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
RHEA:62219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoepoxydon + NADP(+) <=> H(+) + NADPH + phyllostine
RHEA:60647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + androsterone <=> adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)
REACT:R-HSA-183072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR non-clathrin mediated endocytosis (Homo sapiens)
REACT:R-BTA-8866283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)
RHEA:53061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyestrone + UDP-alpha-D-glucuronate => estrone 4-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:19152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + NAD(+) <=> H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
GO:0102100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycothiol-arsenate ligase activity
REACT:R-DRE-8875540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 recruits CRK,CRKL to MET (Danio rerio)
RHEA:63475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-hexaprenol + ATP <=> ADP + all-trans-hexaprenyl phosphate + H(+)
REACT:R-GGA-8864307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Gallus gallus)
RHEA:21744	skos:altLabel	"1-aminocyclopropane-1-carboxylic acid synthase"
RHEA:21744	skos:altLabel	"S-adenosyl-L-methionine methylthioadenosine-lyase"
RHEA:21744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine
RHEA:21744	skos:altLabel	"aminocyclopropanecarboxylate synthase"
RHEA:21744	skos:altLabel	"ACC synthase"
RHEA:21744	skos:prefLabel	"1-aminocyclopropane-1-carboxylate synthase"
RHEA:21744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-aminocyclopropane-1-carboxylate synthase"
RHEA:12721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine
RHEA:12721	skos:prefLabel	"spermidine synthase"
RHEA:12721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spermidine synthase"
RHEA:12721	skos:altLabel	"aminopropyltransferase"
RHEA:12721	skos:altLabel	"putrescine aminopropyltransferase"
REACT:R-XTR-9650858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Meglitinides bind ABCC8 (Xenopus tropicalis)
GO:0008701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HOA
GO:0008701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-oxovalerate pyruvate-lyase activity
GO:0008701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxovalerate aldolase activity
GO:0008701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity
GO:0008701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DmpG
GO:0008701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-oxopentanoate pyruvate-lyase activity
GO:0008701	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-2-ketovalerate aldolase activity
REACT:R-CFA-5696356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSCAR binds collagen and SP-D (Canis familiaris)
REACT:R-XTR-193816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Xenopus tropicalis)
RHEA:65424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + NAD(+)(out) = AMP(out) + NAD(+)(in)
RHEA:32294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoethanolamine + 3 S-adenosyl-L-methionine <=> 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine
REACT:R-SPO-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Schizosaccharomyces pombe)
REACT:R-HSA-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
GO:0015166	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	sugar/polyol channel activity
GO:0015166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyol transmembrane transporter activity
GO:0015166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Homo sapiens)
REACT:R-SSC-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Sus scrofa)
REACT:R-CEL-191763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snRNP:Snurportin complex formation (Caenorhabditis elegans)
EC:3.4.23.23	skos:prefLabel	"mucorpepsin"
EC:3.4.23.23	skos:altLabel	"Mucor rennin"
EC:3.4.23.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mucorpepsin"
REACT:R-DME-110354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of OGG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)
REACT:R-XTR-9012556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Xenopus tropicalis)
REACT:R-MMU-9758090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Mus musculus)
REACT:R-RNO-8949659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Rattus norvegicus)
REACT:R-DRE-870477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Danio rerio)
REACT:R-GGA-6784676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)
REACT:R-MMU-8987105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Mus musculus)
RHEA:70508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O => dimethylallyl phosphate + H(+) + phosphate
REACT:R-SCE-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Saccharomyces cerevisiae)
REACT:R-CFA-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Canis familiaris)
REACT:R-CFA-6797653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMGDH:FAD oxidatively demethylates DMGLY to SARC (Canis familiaris)
RHEA:14905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine
RHEA:14905	skos:altLabel	"phosphoribosyldiphosphate 5-amidotransferase"
RHEA:14905	skos:altLabel	"glutamine phosphoribosylpyrophosphate amidotransferase"
RHEA:14905	skos:prefLabel	"amidophosphoribosyltransferase"
RHEA:14905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amidophosphoribosyltransferase"
REACT:R-MMU-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Mus musculus)
RHEA:64282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetophenone + L-alanine => (S)-1-phenylethylamine + pyruvate
RHEA:46592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-2064421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds ZO-2 (TJP2) (Sus scrofa)
REACT:R-PFA-2162192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHB and all-E-10PrP2 are combined into DHB by COQ2 (Plasmodium falciparum)
REACT:R-XTR-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Xenopus tropicalis)
REACT:R-DRE-8868648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)
RHEA:49861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
GO:0050661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP binding
GO:0050661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide adenine dinucleotide phosphate binding
GO:0050661	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP+ or NADPH binding
GO:0050661	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP or NADPH binding
REACT:R-GGA-422048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acyl Ghrelin and C-Ghrelin are secreted (Gallus gallus)
RHEA:49805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropan-1-amine + FMNH2 + O2 => FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine
REACT:R-BTA-5691150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFR2 dimer binds 2xholoTF (Bos taurus)
REACT:R-RNO-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Rattus norvegicus)
REACT:R-HSA-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Homo sapiens)
REACT:R-HSA-1168777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metalloprotease cleavage of GHR (Homo sapiens)
REACT:R-BTA-5638004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 binds ARL3:GTP:UNC119B (Bos taurus)
REACT:R-SPO-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Schizosaccharomyces pombe)
RHEA:59378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxyprephenate => 4-amino-4-deoxychorismate
GO:0003973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxy-acid oxidase activity
GO:0003973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxyacid oxidase A
GO:0003973	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydroxy-acid oxidase B activity
GO:0003973	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0003973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-alpha-hydroxy acid oxidase
GO:0003973	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	medium-chain-(S)-2-hydroxy-acid oxidase activity
GO:0003973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-2-hydroxy acid oxidase
GO:0003973	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0003973	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hydroxy-acid oxidase A activity
GO:0003973	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolate oxidase activity
REACT:R-BTA-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Bos taurus)
REACT:R-GGA-381518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAAP-A proteolyzes IGF:IGFBP4 (Gallus gallus)
RHEA:12076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic primary alcohol + NAD(+) = an aromatic aldehyde + H(+) + NADH
RHEA:12076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aryl-alcohol dehydrogenase"
RHEA:12076	skos:altLabel	"benzyl alcohol dehydrogenase"
RHEA:12076	skos:prefLabel	"aryl-alcohol dehydrogenase"
RHEA:12076	skos:altLabel	"p-hydroxybenzyl alcohol dehydrogenase"
REACT:R-CFA-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Canis familiaris)
RHEA:52720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O = 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)
RHEA:52720	skos:prefLabel	"tRNA-5-methyluridine(54) 2-sulfurtransferase"
RHEA:52720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-5-methyluridine(54) 2-sulfurtransferase"
REACT:R-DME-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)
REACT:R-CEL-8952996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 forms homodimers (Caenorhabditis elegans)
RHEA:65715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-glucose
GO:0106415	skos:prefLabel	"muramoyltetrapeptide carboxypeptidase"
GO:0106415	skos:altLabel	"carboxypeptidase IIW"
GO:0106415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"muramoyltetrapeptide carboxypeptidase"
GO:0106415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	muramoyltetrapeptide carboxypeptidase activity
GO:0106415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine = D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl
REACT:R-SSC-1295599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 translocates to the plasma membrane (Sus scrofa)
GO:0016867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring acyl groups"
GO:0016867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intramolecular transferase activity, transferring acyl groups
GO:0016867	skos:prefLabel	"Transferring acyl groups"
GO:0033225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phosphonoethylamine transporting ATPase activity
GO:0033225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 2-aminoethylphosphonate transporter activity
GO:0033225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ciliatine transporter activity
GO:0033225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminoethylphosphonate transporting ATPase activity
GO:0033225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-phosphonoethylamine transmembrane transporter activity
GO:0033225	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-aminoethylphosphonate transmembrane transporter activity
GO:0033225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ciliatine transportingATPase activity
GO:0033225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoethylphosphonate-transporting ATPase activity
GO:0033225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled 2-aminoethylphosphonate transporter activity
GO:0033225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate(out) + ATP + H2O = (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate
REACT:R-XTR-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Xenopus tropicalis)
RHEA:14016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + taurolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate
REACT:R-CEL-5653873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Caenorhabditis elegans)
REACT:R-DRE-158354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Danio rerio)
REACT:R-RNO-9638120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU4 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)
RHEA:14768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine h + O2 <=> CO2 + excited coelenteramide h monoanion + H(+) + hnu
REACT:R-CFA-422104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase octanoylates Proghrelin (Canis familiaris)
RHEA:54500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate = beta-geranylfarnesene + diphosphate
REACT:R-SSC-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Sus scrofa)
RHEA:55877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aequorin] + coelenterazine => apo-[aequorin]--coelenterazine
RHEA:25748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-2454113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 transports 11cRAL to rod photoreceptor outer segment (Bos taurus)
REACT:R-GGA-378952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin is a heterodimer (Gallus gallus)
REACT:R-DRE-159796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor IX to factor IX (Danio rerio)
REACT:R-HSA-156723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF20A (MKL2) by phosphorylation (Homo sapiens)
REACT:R-CEL-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Caenorhabditis elegans)
REACT:R-GGA-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Gallus gallus)
REACT:R-DME-5617179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates TNNI3 (Drosophila melanogaster)
REACT:R-MMU-5696482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTF1 binds LIFR:JAKs (Mus musculus)
REACT:R-CFA-2545203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cleaved cohesin (Canis familiaris)
RHEA:16237	skos:altLabel	"rotamase"
RHEA:16237	skos:altLabel	"peptidyl-prolyl cis-trans isomerase"
RHEA:16237	skos:altLabel	"cyclophilin"
RHEA:16237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
RHEA:16237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidylprolyl isomerase"
RHEA:16237	skos:altLabel	"peptidylprolyl cis-trans isomerase"
RHEA:16237	skos:prefLabel	"peptidylprolyl isomerase"
RHEA:16237	skos:altLabel	"PPIase"
REACT:R-BTA-9709454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR binds EPOR agonists (Bos taurus)
RHEA:14116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O <=> a 3'-end 2'-deoxyribonucleotide-DNA + phosphate
RHEA:64034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose
RHEA:35051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose(out) = N,N'-diacetylchitobiose(in)
RHEA:23944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP
RHEA:23944	skos:prefLabel	"coniferyl-alcohol glucosyltransferase"
RHEA:23944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coniferyl-alcohol glucosyltransferase"
REACT:R-DDI-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Dictyostelium discoideum)
REACT:R-SSC-3215448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Sus scrofa)
RHEA:60337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-HSA-5627891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol (Homo sapiens)
REACT:R-HSA-174171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A with the APC/C (Homo sapiens)
REACT:R-HSA-1369114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR binds SHP2 (PTPN11) (Homo sapiens)
REACT:R-SSC-2243931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-lysinonorleucine cross-links (Sus scrofa)
RHEA:72229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + 2 Na(+)(in) + sarcosine(in) => chloride(out) + 2 Na(+)(out) + sarcosine(out)
REACT:R-GGA-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Gallus gallus)
RHEA:70977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine(in) + L-aspartate(out) => 3-sulfino-L-alanine(out) + L-aspartate(in)
REACT:R-HSA-9022186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A3 gene expression is stimulated by MECP2:CREB1 complex (Homo sapiens)
REACT:R-CEL-5419261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Caenorhabditis elegans)
REACT:R-SSC-5654653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates FRS3 (Sus scrofa)
REACT:R-BTA-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Bos taurus)
RHEA:11179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kojibiose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose
REACT:R-SSC-9023968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Sus scrofa)
RHEA:12362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-(2-methylcrotonoyloxy)lupanine + CoA => (2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine
RHEA:47145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-9605600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Homo sapiens)
REACT:R-SSC-4641147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DACT1 binds DVL2 (Sus scrofa)
RHEA:23922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate
REACT:R-RNO-432712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Rattus norvegicus)
REACT:R-HSA-9622377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB mRNA is translated to yield CEBPB protein (Homo sapiens)
REACT:R-CEL-1483222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETA is phosphorylated to PETA by CHK/ETNK (Caenorhabditis elegans)
RHEA:28230	skos:altLabel	"CYP71BL2"
RHEA:28230	skos:prefLabel	"costunolide synthase"
RHEA:28230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"costunolide synthase"
RHEA:28230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyacetone + NAD(+) => H(+) + methylglyoxal + NADH
REACT:R-CFA-444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CXCR5 binds CXCL13 (Canis familiaris)
REACT:R-RNO-8876616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND6A,B exchange GTP for GDP on RAB14 (Rattus norvegicus)
RHEA:54107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-DRE-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Danio rerio)
REACT:R-SSC-8956639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds YAP1 (Sus scrofa)
REACT:R-XTR-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Xenopus tropicalis)
REACT:R-BTA-5684008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBN binds KPNA2 (Bos taurus)
REACT:R-DRE-420593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR:PVRL3 trans heterodimer interaction (Danio rerio)
RHEA:33130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + salicin-6-phosphate <=> beta-D-glucose 6-phosphate + salicyl alcohol
RHEA:61600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbD protein]-disulfide + [protein]-dithiol = [DsbB protein]-dithiol + [protein]-disulfide
REACT:R-DRE-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Danio rerio)
REACT:R-DDI-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Dictyostelium discoideum)
RHEA:27462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glycero-alpha-D-manno-heptose
RHEA:63476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADPH
REACT:R-DRE-76472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ethylene is oxidized to Ethylene oxide by CYP1A1 (Danio rerio)
RHEA:23610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanurate + isopropylamine => H(+) + H2O + N-isopropylammelide
REACT:R-BTA-70501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyruvate, HCO3-, and ATP react to form oxaloacetate, ADP, and phosphate (Bos taurus)
REACT:R-HSA-430180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK recruits WASP (Homo sapiens)
REACT:R-SSC-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)
REACT:R-CFA-112437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NELF complex  (Canis familiaris)
RHEA:38911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenacoside B + H2O = 26-desgluco-avenacoside B + D-glucose
RHEA:38911	skos:prefLabel	"avenacosidase"
RHEA:38911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"avenacosidase"
RHEA:30409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin] => hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin]
RHEA:47316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-DRE-5685985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Danio rerio)
RHEA:10681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline => D-proline
GO:0102283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketodihydrosphinganine (C20) reductase activity
REACT:R-DME-6805126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates TP53 (Drosophila melanogaster)
REACT:R-HSA-2972966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter (Homo sapiens)
GO:0015311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoamine:proton antiporter activity
GO:0015311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoamine:hydrogen antiporter activity
REACT:R-DME-1475422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPS is phosphorylated by cGMP-dependant protein kinase II (Drosophila melanogaster)
RHEA:56200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP
RHEA:41008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin => 6-linalyl-2-O,3-dimethylflaviolin + diphosphate
RHEA:13120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)
REACT:R-CFA-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Canis familiaris)
REACT:R-DRE-5669158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF2 binds PAK1 (Danio rerio)
REACT:R-MMU-9026003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Mus musculus)
REACT:R-DDI-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
REACT:R-HSA-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
RHEA:13560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + gamma-L-glutamyl-L-cysteine + glycine <=> ADP + glutathione + H(+) + phosphate
RHEA:63851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 <=> 2 3',4'-dihydroxyaurone + 2 H2O
RHEA:22655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O <=> 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate
REACT:R-DME-1981157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of collagen propeptide hydroxylysines (Drosophila melanogaster)
REACT:R-HSA-174587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Homo sapiens)
REACT:R-XTR-9748979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Xenopus tropicalis)
RHEA:61655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate
RHEA:48608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 2,3-saturated acyl-CoA = a 2,3-dehydroacyl-CoA + AH2
RHEA:22336	skos:prefLabel	"betaine--homocysteine S-methyltransferase"
RHEA:22336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"betaine--homocysteine S-methyltransferase"
RHEA:22336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + L-homocysteine = L-methionine + N,N-dimethylglycine
RHEA:48941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-aminoacyl-L-amino acid + H2O => 2 an L-alpha-amino acid
REACT:R-BTA-1358801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds RNF41 ubiquitin ligase (Bos taurus)
REACT:R-HSA-6799466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 dimerizes (Homo sapiens)
RHEA:43561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate
GO:0043262	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-diphosphatase activity
GO:0043262	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphatase activity
GO:0043262	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADPase activity
GO:0043262	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ADP diphosphatase activity
GO:0043262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP phosphatase activity
GO:0043262	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP diphosphohydrolase activity
GO:0043262	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ADPase
GO:0043262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine-diphosphatase activity
REACT:R-DRE-9006873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT binding (Danio rerio)
GO:1990300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cellulosome binding
GO:1990300	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	scaffoldin complex binding
REACT:R-HSA-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Homo sapiens)
REACT:R-GGA-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Gallus gallus)
RHEA:53619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (+)-isoafricanol + diphosphate
REACT:R-GGA-5658231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs stimulate RAS GTPase activity (Gallus gallus)
RHEA:47765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(1369) in 16S rRNA => 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-9707186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 binds ALOX5 inhibitors (Mus musculus)
REACT:R-DRE-5625848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Danio rerio)
REACT:R-DRE-5685604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF6 binds SLAMF6 (Danio rerio)
RHEA:44480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
RHEA:53916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acyl-L-lysyl-[protein]
REACT:R-DRE-9012000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Danio rerio)
REACT:R-GGA-9708859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Gallus gallus)
REACT:R-GGA-2730889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)
REACT:R-RNO-1964501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to Core 6 glycoprotein (Rattus norvegicus)
RHEA:65781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-8941628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
REACT:R-GGA-8852331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 translocates to the nucleus (Gallus gallus)
EC:3.4.21.43	skos:altLabel	"C5 convertase"
EC:3.4.21.43	skos:prefLabel	"classical-complement-pathway C3/C5 convertase"
EC:3.4.21.43	skos:altLabel	"complement C2"
EC:3.4.21.43	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"classical-complement-pathway C3/C5 convertase"
EC:3.4.21.43	skos:altLabel	"C3 convertase"
REACT:R-DDI-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Dictyostelium discoideum)
REACT:R-RNO-9714924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to soluble TNF trimer (Rattus norvegicus)
REACT:R-DRE-2168923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XVIII endostatin release (Danio rerio)
REACT:R-DME-5610727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Drosophila melanogaster)
REACT:R-SSC-9010815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLITs bind keratan sulfate (Sus scrofa)
RHEA:46821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:38979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:71943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + 3 Na(+)(out) = (S)-malate(in) + 3 Na(+)(in)
REACT:R-HSA-9018538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLGAP5 gene transcription is stimulated by NOTCH3 (Homo sapiens)
REACT:R-BTA-2984220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1:CCNB phosphorylates NEK9 (Bos taurus)
REACT:R-CFA-379387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DA to form 3MT (Canis familiaris)
RHEA:45927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA
REACT:R-HSA-8983835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Homo sapiens)
REACT:R-CFA-2046100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Canis familiaris)
REACT:R-MMU-3159253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAB adenosylates cob(I)alamin (Mus musculus)
REACT:R-SSC-8848606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates PXN (Sus scrofa)
RHEA:35809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-D-arabinonate
REACT:R-CFA-8850356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds microbial lipid-based antigen via CD1 (Canis familiaris)
RHEA:56880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-Delta(5)-steroid + NADP(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADPH
REACT:R-GGA-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Gallus gallus)
REACT:R-RNO-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Rattus norvegicus)
RHEA:48811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
REACT:R-HSA-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Homo sapiens)
RHEA:20100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate <=> 2-dehydro-3-deoxy-D-gluconate + H2O
RHEA:38457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O
REACT:R-HSA-9664273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers (Homo sapiens)
REACT:R-GGA-351894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of BAP31 (Gallus gallus)
RHEA:59870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+) => 4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine
REACT:R-DME-372480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Drosophila melanogaster)
REACT:R-XTR-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Xenopus tropicalis)
RHEA:17128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine <=> 2-oxoglutarate + N-(2-aminobutanoyl)glycine
RHEA:44739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dihydroxyacetone phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate + CoA
REACT:R-RNO-9688459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds HSP90:CDC37 (Rattus norvegicus)
REACT:R-GGA-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Gallus gallus)
RHEA:52654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eburicol + H(+) + S-adenosyl-L-homocysteine => lanosterol + S-adenosyl-L-methionine
REACT:R-BTA-6795667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the cytosol (Bos taurus)
REACT:R-SSC-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Sus scrofa)
RHEA:61759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside A + UDP
REACT:R-SSC-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Sus scrofa)
REACT:R-HSA-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
RHEA:14532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + phosphate
REACT:R-DRE-9617067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Danio rerio)
RHEA:35767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosterigmatocystin + S-adenosyl-L-methionine = 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine
RHEA:67646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dZTP => ATP + dZDP
RHEA:46363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:10183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-10-formyltetrahydrofolate + H2O + NADP(+) <=> (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH
RHEA:37775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DRE-1605736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers (Danio rerio)
REACT:R-HSA-9686061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nucleoprotein is ADP-ribosylated (Homo sapiens)
RHEA:39944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA
RHEA:42115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-hydroxypregn-4-en-3-one + NADP(+) <=> H(+) + NADPH + progesterone
REACT:R-RNO-9708104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE5A dimer binds PDE5A inhibitors (Rattus norvegicus)
REACT:R-MMU-3341397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
REACT:R-CEL-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Caenorhabditis elegans)
GO:0017018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin phosphatase myosin binding
GO:0017018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Homo sapiens)
GO:0017018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin phosphatase activity
GO:0017018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin phosphatase, intrinsic catalyst activity
REACT:R-XTR-193789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Xenopus tropicalis)
RHEA:67268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210972
RHEA:15402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + UDP-alpha-D-glucose => a dolichyl beta-D-glucosyl phosphate + UDP
REACT:R-SPO-1247960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 MAPK (Schizosaccharomyces pombe)
RHEA:70129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:64459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine
RHEA:54764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)
RHEA:14483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O
REACT:R-RNO-4719436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO1 (Rattus norvegicus)
REACT:R-CEL-4551649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO1 (Caenorhabditis elegans)
RHEA:59611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl-L-lysine + H2O <=> beta-alanine + L-lysine
REACT:R-CFA-9716258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimethyl fumarate modifies Cys191 in GSDMD (Canis familiaris)
REACT:R-BTA-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Bos taurus)
REACT:R-DME-6781764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)
REACT:R-CFA-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Canis familiaris)
REACT:R-BTA-209973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is diiodinated (Bos taurus)
REACT:R-GGA-9706399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 hydrolyzes ATP (Gallus gallus)
REACT:R-DDI-6807866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the ERGIC (Dictyostelium discoideum)
REACT:R-DME-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
RHEA:68320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2,4,5-triphosphate + H2O = 1D-myo-inositol 2,5-bisphosphate + phosphate
REACT:R-DDI-6791219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Dictyostelium discoideum)
REACT:R-SCE-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Saccharomyces cerevisiae)
RHEA:71235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]
REACT:R-HSA-2168885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin binds Hemoglobin (Homo sapiens)
REACT:R-HSA-8876497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	InlA binds CDH1 (Homo sapiens)
REACT:R-BTA-6806647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Bos taurus)
RHEA:15147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose => D-maltose
REACT:R-SSC-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Sus scrofa)
REACT:R-BTA-3322434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP dissociates from ub-TLE (Bos taurus)
REACT:R-SSC-5693578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDP1 and TDP2 process unligatable DSB ends (Sus scrofa)
GO:0102881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-beta-barbatene synthase activity
REACT:R-MMU-5686685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Mus musculus)
RHEA:72848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate(in) + ADP(out) => adenosine 3',5'-bisphosphate(out) + ADP(in)
REACT:R-HSA-5693061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAMBP binds STAM (Homo sapiens)
RHEA:36541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoylsphinganine => hexadecanoyl-CoA + sphinganine
REACT:R-XTR-446215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Xenopus tropicalis)
REACT:R-RNO-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Rattus norvegicus)
REACT:R-MMU-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Mus musculus)
RHEA:20261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7-trioxododecanoyl-CoA = CO2 + CoA + olivetol
REACT:R-DRE-6813659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE, CTSG or PRTN3 binds bacteria (Danio rerio)
RHEA:39333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH
RHEA:22341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + NADP(+) => 3-hydroxybenzaldehyde + H(+) + NADPH
REACT:R-RNO-351341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of Proactivator polypeptide (Rattus norvegicus)
GO:0102098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galacturonate reductase activity
REACT:R-DRE-2424476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV2/3 (Danio rerio)
REACT:R-SSC-5694445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNIH1 binds TFGA and AREG precursors (Sus scrofa)
REACT:R-RNO-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)
REACT:R-CEL-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Caenorhabditis elegans)
REACT:R-DME-83805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Drosophila melanogaster)
REACT:R-MMU-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Mus musculus)
RHEA:17727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-cis-aconitate + H2O => (2S,3S)-2-methylcitrate
REACT:R-HSA-9026006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Homo sapiens)
REACT:R-DRE-1433508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC alpha interacts with and phosphorylates KIT (Danio rerio)
RHEA:31069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(1)-piperideine-2-carboxylate + H2O => 6-amino-2-oxohexanoate
REACT:R-DRE-189442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAS condenses SUCC-CoA and Gly to form dALA (Danio rerio)
RHEA:46432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-SSC-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Sus scrofa)
REACT:R-RNO-4084999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU1 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)
RHEA:41953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
RHEA:40804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADPH
REACT:R-SSC-352052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Sus scrofa)
RHEA:69508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamino-1,5-lactone = H(+) + N-acetyl-D-glucosaminate
RHEA:11519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + succinyl-CoA <=> CoA + H(+) + succinate
EC:2.4.1.115	skos:prefLabel	"anthocyanidin 3-O-glucosyltransferase"
EC:2.4.1.115	skos:altLabel	"uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase"
EC:2.4.1.115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanidin 3-O-glucosyltransferase"
EC:2.4.1.115	skos:altLabel	"UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase"
EC:2.4.1.115	skos:altLabel	"UDP-glucose:cyanidin-3-O-glucosyltransferase"
EC:2.4.1.115	skos:altLabel	"UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase"
EC:2.4.1.115	skos:altLabel	"3-GT"
REACT:R-DRE-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Danio rerio)
REACT:R-CFA-9021068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs bind CAVs (Canis familiaris)
REACT:R-GGA-909722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-STAT2:p-STAT1 dimer (Gallus gallus)
RHEA:69526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + H2O2 => D-sorbitol + O2
REACT:R-XTR-9705794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 binds SRD5A2 inhibitors (Xenopus tropicalis)
REACT:R-BTA-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Bos taurus)
REACT:R-RNO-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Rattus norvegicus)
REACT:R-SSC-5694436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 and MIA3 dissociate from procollagen VII vesicle (Sus scrofa)
RHEA:12442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + L-lysine + NADH => H2O + L-saccharopine + NAD(+)
REACT:R-DDI-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Dictyostelium discoideum)
RHEA:25683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:40227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + desulfo-A47934 = A47934 + adenosine 3',5'-bisphosphate + H(+)
RHEA:40227	skos:prefLabel	"desulfo-A47934 sulfotransferase"
RHEA:40227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"desulfo-A47934 sulfotransferase"
REACT:R-HSA-169260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Homo sapiens)
REACT:R-PFA-8870466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGGT:CHM binds RABs (Plasmodium falciparum)
REACT:R-XTR-4570499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Xenopus tropicalis)
REACT:R-RNO-5687097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3 binds ETV4 (Rattus norvegicus)
REACT:R-XTR-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Xenopus tropicalis)
REACT:R-GGA-211193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homodimerization  of DFF40 (Gallus gallus)
REACT:R-HSA-8932309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 translocates from cytosol to nucleoplasm (Homo sapiens)
EC:3.2.1.36	skos:prefLabel	"hyaluronoglucuronidase"
EC:3.2.1.36	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hyaluronoglucuronidase"
EC:3.2.1.36	skos:altLabel	"hyaluronidase"
RHEA:51512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxamate = NH4(+) + oxalate
RHEA:51512	skos:prefLabel	"oxamate amidohydrolase"
RHEA:51512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxamate amidohydrolase"
RHEA:62411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine <=> 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Caenorhabditis elegans)
RHEA:70576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic UMP + H2O => H(+) + UMP
REACT:R-XTR-5693356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEMIP hydrolyses HA (Xenopus tropicalis)
RHEA:53720	skos:prefLabel	"N-acetylmuramate 1-kinase"
RHEA:53720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylmuramate 1-kinase"
RHEA:53720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate
RHEA:29673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(out) => Ca(2+)(in)
REACT:R-SCE-8857686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FITM1, FITM2 bind TAGs (Saccharomyces cerevisiae)
RHEA:13622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose => 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose
REACT:R-DRE-9731632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)
RHEA:43924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pregnenolone = H(+) + NADH + pregn-5-ene-3,20-dione
REACT:R-XTR-212252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Xenopus tropicalis)
RHEA:54065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => 10-epi-cubebol + diphosphate
RHEA:40317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-glutaconyl-CoA + H2O2 => glutaryl-CoA + O2
RHEA:33967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H(+)
RHEA:33967	skos:prefLabel	"2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase"
RHEA:33967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase"
REACT:R-BTA-9758682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C1 hydrogenates PREDN,PREDL (Bos taurus)
REACT:R-CFA-5423653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGST trimers transfer GS from GSH to AFXBO and AFNBO (Canis familiaris)
RHEA:28387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP
REACT:R-HSA-8936979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
REACT:R-MMU-450394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Mus musculus)
RHEA:52022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + resolvin E2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2
REACT:R-HSA-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Homo sapiens)
REACT:R-XTR-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Xenopus tropicalis)
REACT:R-DRE-8937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Danio rerio)
REACT:R-BTA-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Bos taurus)
REACT:R-XTR-4085133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUM (lumican) binds integrin alpha2beta1 (Xenopus tropicalis)
RHEA:64179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-tryptophan <=> (9Z)-octadecenoate + L-tryptophan
REACT:R-XTR-8874705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Xenopus tropicalis)
REACT:R-XTR-8853755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Xenopus tropicalis)
REACT:R-RNO-69140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA binds to the Flap (Rattus norvegicus)
REACT:R-MMU-8948063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Mus musculus)
REACT:R-BTA-1236954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides by IRAP in endocytic vesicles (Bos taurus)
REACT:R-MMU-1011600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rabenosyn-5 connects  Rab5 to VPS-45 (Mus musculus)
RHEA:33767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O
REACT:R-RNO-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Rattus norvegicus)
RHEA:11569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP => 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate
REACT:R-DME-354149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
RHEA:50899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O <=> (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate
RHEA:57183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + methylglyoxal <=> N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]
RHEA:58782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine => a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine
GO:0033765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid dehydrogenase activity, acting on the CH-CH group of donors
REACT:R-DRE-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Danio rerio)
REACT:R-DRE-5656158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLZ elongates POLI-incorporated dNMP (Danio rerio)
REACT:R-DRE-2130731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of COPII vesicle (Danio rerio)
REACT:R-RNO-110360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to the AP site (Rattus norvegicus)
RHEA:18907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H(+) + phosphate => H2O + phosphonoacetaldehyde
RHEA:72101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) + O-acetyl-(R)-carnitine(in) => Na(+)(out) + O-acetyl-(R)-carnitine(out)
RHEA:21482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-2-furoyl-CoA + AH2 + H(+) => 2-furoyl-CoA + A + H2O
EC:3.2.1.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-mannosidase"
EC:3.2.1.24	skos:prefLabel	"alpha-mannosidase"
RHEA:70125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:24617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + NADP(+) => estrone + H(+) + NADPH
REACT:R-CFA-195690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Canis familiaris)
REACT:R-DDI-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Dictyostelium discoideum)
RHEA:21989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside => 4'''-demalonylsalvianin + CoA
REACT:R-MMU-1236398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds NRGs or EGF-like ligands (Mus musculus)
GO:0000293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron chelate reductase activity
GO:0000293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric chelate reductase activity
GO:0000293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric-chelate reductase activity
REACT:R-GGA-8987040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Gallus gallus)
RHEA:62740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2
REACT:R-BTA-5649705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)
REACT:R-RNO-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Rattus norvegicus)
REACT:R-HSA-1225978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers (Homo sapiens)
RHEA:30438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)
REACT:R-CFA-3928578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH receptors autophosphorylate (Canis familiaris)
GO:0004180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxypeptidase activity
REACT:R-SSC-561253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A12 exchanges extracellular urate for cytosolic LACT (Sus scrofa)
RHEA:71828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate(in) + H(+)(in) => arsenate(out) + H(+)(out)
REACT:R-CEL-9634850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT (Caenorhabditis elegans)
RHEA:17212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O <=> 2-formylglutarate + NH4(+)
RHEA:11266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NAD(+) => H(+) + NADH + O2
REACT:R-RNO-5649734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates NEIL1,NEIL2-generated single strand break (Rattus norvegicus)
RHEA:46162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + NAD(+) => a quinone + H(+) + NADH
RHEA:69222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+) => a (Z)-glucosinolate + H2O
REACT:R-CEL-5672828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates AKT1S1 (Caenorhabditis elegans)
REACT:R-DME-174088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of cell cycle proteins with the APC/C:Cdh1 complex (Drosophila melanogaster)
REACT:R-CEL-201510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)
REACT:R-CFA-6805126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates TP53 (Canis familiaris)
REACT:R-MTU-936642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deacetylation of O-acetylserine and sulfhydrylation using CysK1 (Mycobacterium tuberculosis)
REACT:R-DRE-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Danio rerio)
RHEA:25790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + succinate semialdehyde => 4-hydroxy-2-oxoheptanedioate
REACT:R-HSA-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Homo sapiens)
RHEA:47249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone => 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate
REACT:R-HSA-2167942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII ectodomain shedding (Homo sapiens)
RHEA:39148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA
REACT:R-HSA-9727886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 SUMO-p-N binds to NPM1 (Homo sapiens)
REACT:R-DME-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Drosophila melanogaster)
REACT:R-RNO-8848939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds KHDRBS1 (Rattus norvegicus)
REACT:R-MMU-2404195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Mus musculus)
REACT:R-SSC-428205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [Golgi] (Sus scrofa)
REACT:R-XTR-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Xenopus tropicalis)
RHEA:62083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-sulfate + NADP(+) <=> 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH
RHEA:65651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine <=> a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine
RHEA:37303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycyl-L-asparagine(out) + H2O = ADP + glycyl-L-asparagine(in) + H(+) + phosphate
REACT:R-GGA-176879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein(a) + LDL => Lp(a) (Gallus gallus)
REACT:R-MMU-202939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of E-Cadherin (Mus musculus)
REACT:R-MMU-2066778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)
REACT:R-HSA-9672173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGFRA extracellular domain dimers (Homo sapiens)
REACT:R-GGA-8943003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH polyubiquitinates monoubiquitinated PCNA (Gallus gallus)
RHEA:25697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
GO:0033736	skos:altLabel	"L-lysine-epsilon-oxidase"
GO:0033736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LodA
GO:0033736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-lysine 6-oxidase"
GO:0033736	skos:altLabel	"Lod"
GO:0033736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)
GO:0033736	skos:altLabel	"marinocine"
GO:0033736	skos:prefLabel	"L-lysine 6-oxidase"
GO:0033736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine 6-oxidase activity
GO:0033736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	marinocine
GO:0033736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Lod
GO:0033736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine:oxygen 6-oxidoreductase (deaminating) activity
GO:0033736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine-epsilon-oxidase activity
GO:0102071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxy-18-hydroxystearate hydrolase activity
RHEA:15063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)
REACT:R-XTR-163733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of FAS monomer gene by ChREBP:MLX (Xenopus tropicalis)
REACT:R-HSA-1989765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ABCA1 (Homo sapiens)
REACT:R-DRE-1236940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exogenous soluble antigen targeted to more stable early endosome (Danio rerio)
EC:2.4.99.5	skos:prefLabel	"galactosyldiacylglycerol alpha-2,3-sialyltransferase"
EC:2.4.99.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactosyldiacylglycerol alpha-2,3-sialyltransferase"
RHEA:35197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-quinate(out) => L-quinate(in)
RHEA:52224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O
RHEA:52224	skos:prefLabel	"heme oxygenase (biliverdin-IX-beta and delta-forming)"
RHEA:52224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heme oxygenase (biliverdin-IX-beta and delta-forming)"
RHEA:52224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 3 H(+) + heme b + 3 O2 = 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O
REACT:R-DRE-9731393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA, EDNRB bind non-selective ERAs (Danio rerio)
RHEA:46894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate => 2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate
RHEA:40608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycerol + H2O => glycerol + H(+) + tetradecanoate
REACT:R-CEL-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Caenorhabditis elegans)
RHEA:50838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2
RHEA:67412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
GO:0004466	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	palmitoyl-CoA dehydrogenase activity
GO:0004466	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain acyl-coenzyme A dehydrogenase activity
GO:0004466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-acyl-CoA dehydrogenase"
GO:0004466	skos:prefLabel	"long-chain-acyl-CoA dehydrogenase"
GO:0004466	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	palmitoyl-coenzyme A dehydrogenase activity
GO:0004466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0004466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-acyl-CoA dehydrogenase activity
RHEA:24469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dimethylaniline + NADPH + O2 => H2O + N,N-dimethylaniline N-oxide + NADP(+)
REACT:R-PFA-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Plasmodium falciparum)
RHEA:45567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone <=> 5-epi-valiolone
RHEA:12358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate => D-mannose 6-phosphate
REACT:R-HSA-187506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p27 to the nucleoplasm (Homo sapiens)
RHEA:50789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pentan-2-one => (E)-pent-3-en-2-one + H(+) + NADPH
RHEA:53893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-prenyl-L-cysteine + H2O + O2 => a prenal + H2O2 + L-cysteine
RHEA:36902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine
REACT:R-CEL-450690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Caenorhabditis elegans)
REACT:R-MMU-8950780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 binds p-Y693-STAT4 (Mus musculus)
REACT:R-CFA-2142859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growing HA is extruded from the cell by ABCC5 (Canis familiaris)
RHEA:39288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine => dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]
REACT:R-SSC-176059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST trimers transfer GS from GSH to luminal substrates (Sus scrofa)
RHEA:11730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopentanone + H(+) + NADH => cyclopentanol + NAD(+)
REACT:R-SSC-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Sus scrofa)
REACT:R-SSC-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Sus scrofa)
GO:0031850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-type opioid receptor binding
GO:0031850	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enkephalin receptor binding
GO:0031850	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	delta-type opioid receptor ligand
REACT:R-CFA-211224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DFF40 with DFF45 (Canis familiaris)
RHEA:34523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:34523	skos:prefLabel	"GalNAc5-diNAcBac-PP-undecaprenol beta-1,3-glucosyltransferase"
RHEA:34523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GalNAc5-diNAcBac-PP-undecaprenol beta-1,3-glucosyltransferase"
RHEA:39703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH = (13Z)-eicosenoyl-CoA + NADP(+)
RHEA:52863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty acid + ATP + CoA <=> a short-chain fatty acyl-CoA + AMP + diphosphate
RHEA:71751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + glutarate(in) = 2-oxoglutarate(in) + glutarate(out)
GO:0004018	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	succino AMP-lyase activity
GO:0004018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0004018	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	adenylosuccinase activity
GO:0004018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity
GO:0004018	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	adenylosuccinate lyase activity
GO:0004018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity
GO:0008276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein methyltransferase activity
GO:0008276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates ESRs (Homo sapiens)
GO:0008276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein methylase activity
REACT:R-CFA-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Canis familiaris)
REACT:R-HSA-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Homo sapiens)
REACT:R-CEL-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Caenorhabditis elegans)
RHEA:67077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-SCE-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)
REACT:R-GGA-9627078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP9 (Gallus gallus)
RHEA:40981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O
REACT:R-HSA-9035990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HLCS does not biotinylate 6x(PCCA:PCCB) (Homo sapiens)
RHEA:20374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + propanoate => AMP + diphosphate + propanoyl-CoA
REACT:R-DRE-1650808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Danio rerio)
REACT:R-HSA-379887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)
REACT:R-GGA-1112514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK activation (Gallus gallus)
REACT:R-HSA-1433542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV1 (Homo sapiens)
REACT:R-XTR-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Xenopus tropicalis)
REACT:R-DRE-374662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Ezrin to plasma membrane (Danio rerio)
RHEA:57179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + methylglyoxal <=> N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]
REACT:R-DME-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)
RHEA:49956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine 1-carboxylate + O2 = H2O2 + phenazine-1-carboxylate
RHEA:14806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-allose => ADP + D-allose 6-phosphate + H(+)
RHEA:31315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GDP-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)
REACT:R-SSC-8858298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRASLS transfer acyl group from PC to PE to form NAPE (Sus scrofa)
REACT:R-HSA-5685366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y-SHC (Homo sapiens)
RHEA:54389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
GO:0102682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity
RHEA:15741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) = 2,5-dichlorohydroquinone + H(+) + NADH
REACT:R-HSA-1839107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)
RHEA:40541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DRE-9023968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Danio rerio)
RHEA:30305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
RHEA:61907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaenone A + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin II
REACT:R-DRE-9035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysS248-MPST:TXN2 dissociates (Danio rerio)
REACT:R-HSA-1605632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Both hexosaminidase A and B can cleave GalNAc from globoside (Homo sapiens)
REACT:R-BTA-500717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GRIK3 homomer (Bos taurus)
REACT:R-HSA-5210909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANTXR1-bound pagA(197-794) forms oligomers (Homo sapiens)
GO:0102803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thebane O-demethylase activity
REACT:R-HSA-192912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NP binds vRNA (Homo sapiens)
GO:0047619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylcarnitine hydrolase activity
GO:0047619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoylcarnitine hydrolase activity
GO:0047619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine ester hydrolase activity
GO:0047619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl carnitine hydrolase activity
GO:0047619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl-L-carnitine hydrolase activity
GO:0047619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	high activity acylcarnitine hydrolase activity
GO:0047619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain acyl-L-carnitine hydrolase activity
GO:0047619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-acylcarnitine acylhydrolase activity
GO:0047619	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HACH
RHEA:13014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:25964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-benzoin + NADP(+) = benzil + H(+) + NADPH
RHEA:25964	skos:prefLabel	"benzil reductase [(R)-benzoin forming]"
RHEA:25964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzil reductase [(R)-benzoin forming]"
REACT:R-MMU-209821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of N-acetyl-5-HT to form melatonin (Mus musculus)
REACT:R-BTA-5672817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active MTORC1 binds the ULK1 complex (Bos taurus)
REACT:R-CEL-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Caenorhabditis elegans)
REACT:R-BTA-5339535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTPD1 transports C1P from plasma membrane to Golgi membrane (Bos taurus)
RHEA:72624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base => a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base
RHEA:65436	skos:prefLabel	"GDP polyribonucleotidyltransferase"
RHEA:65436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP polyribonucleotidyltransferase"
RHEA:65436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate
RHEA:65436	skos:altLabel	"PRNTase"
REACT:R-BTA-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Bos taurus)
REACT:R-MMU-200410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Mus musculus)
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	organophosphorus hydrolase activity
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OPH
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aryldialkylphosphatase"
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pirimiphos-methyloxon esterase activity
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphotriesterase activity
GO:0004063	skos:altLabel	"aryltriphosphatase"
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	paraoxonase activity
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryldialkylphosphatase activity
GO:0004063	skos:prefLabel	"aryldialkylphosphatase"
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	organophosphate esterase activity
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	paraoxon hydrolase activity
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryltriphosphate dialkylphosphohydrolase activity
GO:0004063	skos:altLabel	"paraoxonase"
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aryltriphosphatase activity
GO:0004063	skos:altLabel	"paraoxon hydrolase"
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	A-esterase activity
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	paraoxon esterase activity
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + paraoxon = 4-nitrophenol + diethylphosphate + 2 H(+)
GO:0004063	skos:altLabel	"A-esterase"
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	esterase E4
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	esterase B1
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	organophosphate hydrolase activity
GO:0004063	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	organophosphorus acid anhydrase activity
GO:0004063	skos:altLabel	"phosphotriesterase"
REACT:R-MMU-5661125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2sR4-HIST1H4 (Mus musculus)
REACT:R-DRE-4615839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO2,3 (Danio rerio)
REACT:R-RNO-1678716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(1) (Rattus norvegicus)
RHEA:63303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine
REACT:R-DME-5579018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1(868-1441) binds PAX3(1-319) (Drosophila melanogaster)
REACT:R-CFA-390835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD1,5 bind DA (Canis familiaris)
RHEA:39022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
REACT:R-DRE-1602417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Danio rerio)
REACT:R-MMU-2161745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Mus musculus)
RHEA:25523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + pseudotropine <=> CoA + H(+) + O-acylpseudotropine
REACT:R-RNO-8877153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 binds PC (Rattus norvegicus)
REACT:R-MMU-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Mus musculus)
RHEA:67256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate
RHEA:71145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoylpyruvate + CO2 + hnu => 3-hydroxyhispidin + O2
REACT:R-GGA-6795460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK1 phosphorylates MDM2 (Gallus gallus)
RHEA:49624	skos:prefLabel	"erythritol kinase (D-erythritol 1-phosphate-forming)"
RHEA:49624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"erythritol kinase (D-erythritol 1-phosphate-forming)"
RHEA:49624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + erythritol = ADP + D-erythritol 1-phosphate + H(+)
REACT:R-HSA-9613451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes (Homo sapiens)
REACT:R-RNO-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Rattus norvegicus)
RHEA:33141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) + L-aspartate(out) => L-alanine(out) + L-aspartate(in)
GO:0047816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose 1-dehydrogenase (NAD+) activity
GO:0047816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinose:NAD+ 1-oxidoreductase activity
GO:0047816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arabinose(fucose)dehydrogenase activity
GO:0047816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-pentose-dehydrogenase activity
REACT:R-GGA-9013144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GAPs stimulate RAC1 GTPase activity (Gallus gallus)
REACT:R-HSA-9612501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK phosphorylates CREB1 (Homo sapiens)
RHEA:21279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NADP(+) <=> D-xylulose + H(+) + NADPH
REACT:R-MMU-1678650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses Heparan sulfate chain(5) (Mus musculus)
REACT:R-SSC-6814682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of early-endosome derived vesicles at the TGN (Sus scrofa)
REACT:R-XTR-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Xenopus tropicalis)
RHEA:66663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-glucosylceramide(in) + H2O <=> ADP + beta-D-glucosylceramide(out) + H(+) + phosphate
REACT:R-MMU-2507854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Mus musculus)
GO:0008081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoric diester hydrolase activity
GO:0008081	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphodiesterase
REACT:R-HSA-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Homo sapiens)
REACT:R-BTA-5607728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Bos taurus)
EC:6.3.2.16	skos:prefLabel	"D-alanine--alanyl-poly(glycerolphosphate) ligase"
EC:6.3.2.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-alanine--alanyl-poly(glycerolphosphate) ligase"
EC:6.3.2.16	skos:altLabel	"D-alanyl-alanyl-poly(glycerolphosphate) synthetase"
EC:6.3.2.16	skos:altLabel	"D-alanine:membrane-acceptor ligase"
RHEA:27669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA
RHEA:72185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine(out) + H(+)(in) => creatinine(in) + H(+)(out)
RHEA:22915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine + pyruvate <=> 3-methyl-2-oxobutanoate + L-alanine
RHEA:65717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a primary linear alkyl sulfate ester + O2 => an aldehyde + CO2 + H(+) + succinate + sulfate
REACT:R-DRE-8943003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH polyubiquitinates monoubiquitinated PCNA (Danio rerio)
REACT:R-DME-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Drosophila melanogaster)
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA binding involved in post-transcriptional gene silencing
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mRNA base-pairing post-transcriptional repressor activity
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA binding involved in quelling
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA binding involved in PTGS
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	mRNA binding translation repressor activity
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA base-pairing posttranscriptional repressor activity
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA base-pairing translational repressor activity
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA binding involved in PTGS
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA binding involved in quelling
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA binding involved in posttranscriptional gene silencing
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA binding involved in cosuppression
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA binding involved in post-transcriptional gene silencing
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA binding involved in posttranscriptional gene silencing
GO:1903231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mRNA binding involved in cosuppression
RHEA:31174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O
REACT:R-HSA-6805479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53RK phosphorylates TP53 (Homo sapiens)
RHEA:61718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-galactofuranose(in) + H(+) + phosphate => ATP + D-galactofuranose(out) + H2O
REACT:R-XTR-1675824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Xenopus tropicalis)
REACT:R-GGA-74101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerization of 11c-retinyl to at-retinyl (Gallus gallus)
REACT:R-CEL-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:47117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoate + glycine => H2O + N-eicosanoylglycinate
RHEA:66561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-noradrenaline + L-glutaminyl-[protein] => 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)
RHEA:64387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine <=> alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine
RHEA:48541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)
RHEA:32923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phospho-(1'-sn-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate
RHEA:72774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-8876454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND3 exchanges GTP for GDP on RAB12 (Danio rerio)
REACT:R-CFA-2327746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 aggregation (Canis familiaris)
REACT:R-HSA-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)
RHEA:62704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine
REACT:R-BTA-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Bos taurus)
REACT:R-HSA-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Homo sapiens)
GO:0052917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase
GO:0052917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity
GO:0052917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-P-mannose:Man(7)GlcNAc(2)-PP-dolichyl mannosyltransferase activity
GO:0052917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity
REACT:R-CFA-3697882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN (Canis familiaris)
RHEA:39284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid(out) => a long-chain fatty acid(in)
REACT:R-MMU-2022383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)
REACT:R-SSC-9647645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD oligomerizes into arc-, slit-shaped structures (Sus scrofa)
REACT:R-SSC-5617179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKACA phosphorylates TNNI3 (Sus scrofa)
GO:0070007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamic-type endopeptidase activity
RHEA:18828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->6)-alpha-D-glucosyl](n) + sucrose <=> [(1->6)-alpha-D-glucosyl](n+1) + D-fructose
REACT:R-CEL-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Caenorhabditis elegans)
GO:0005358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity hydrogen:glucose symporter activity
GO:0005358	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	high-affinity hydrogen/glucose transporter activity
GO:0005358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity glucose:proton symporter activity
GO:0005358	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	high-affinity hydrogen:glucose transporter activity
REACT:R-DDI-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Dictyostelium discoideum)
REACT:R-CFA-9026911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Canis familiaris)
REACT:R-BTA-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Bos taurus)
RHEA:20621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type Zn(2+) transporter"
RHEA:20621	skos:altLabel	"Zn(2+)-exporting ATPase"
RHEA:20621	skos:altLabel	"zinc-translocating P-type ATPase"
RHEA:20621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Zn(2+)(in) = ADP + H(+) + phosphate + Zn(2+)(out)
RHEA:20621	skos:altLabel	"P1B-type ATPase"
RHEA:20621	skos:prefLabel	"P-type Zn(2+) transporter"
GO:0004839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin activating enzyme activity
GO:0004839	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E1 ubiquitin-activating enzyme
REACT:R-MMU-8848110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds activated PTK6 (Mus musculus)
REACT:R-DRE-450434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Danio rerio)
REACT:R-MMU-193695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK interacts with TRAF6 (Mus musculus)
REACT:R-GGA-2029476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Role of myosins in phagosome formation (Gallus gallus)
REACT:R-HSA-6788855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3KRP phosphorylates PsiAm, RibAm (Homo sapiens)
REACT:R-SSC-5684008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBN binds KPNA2 (Sus scrofa)
RHEA:22649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[cytochrome c] => apo-[cytochrome c] + heme b
REACT:R-MMU-74031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP binds CNG channel to form cGMP:CNG channel (Mus musculus)
GO:0018762	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aliphatic nitrile aminohydrolase activity
GO:0018762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aliphatic nitrilase activity
RHEA:48616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene D4 = glycine + leukotriene E4
REACT:R-MMU-6790487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 ubiquitinates SUMOylated XPC (Mus musculus)
RHEA:59961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha)-acetyl-D-methionine => N(alpha)-acetyl-L-methionine
RHEA:16122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouracil + H2O => 3-(carbamoylamino)propanoate + H(+)
RHEA:70008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + ATP + H(+) => 2-aminobenzoyl-AMP + diphosphate
RHEA:34072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP
REACT:R-RNO-4086205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN (osteopontin) degradation by MMP3, MMP7 (Rattus norvegicus)
RHEA:69254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(thiiran-2-yl)acetonitrile + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate
REACT:R-GGA-216757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Gallus gallus)
REACT:R-HSA-8945709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-20 microRNAs bind PTEN mRNA (Homo sapiens)
REACT:R-DDI-193369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Dictyostelium discoideum)
RHEA:22464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]
GO:0015520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracyclin:hydrogen antiporter activity
GO:0015520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracycline:proton antiporter activity
GO:0015520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracyclin:proton antiporter activity
GO:0015520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetracycline:hydrogen antiporter activity
REACT:R-CEL-6797568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind CASK:Protein 4.1 (Caenorhabditis elegans)
REACT:R-HSA-8851866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds RANBP10 (Homo sapiens)
REACT:R-MMU-2730899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BCL10 and MALT1 (Mus musculus)
RHEA:42003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP
RHEA:67896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end uridylyl-adenosine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine
REACT:R-DRE-5654408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates FRS2 (Danio rerio)
REACT:R-SSC-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)
RHEA:34878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH
RHEA:28729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(out) + H(+)(out) => Cu(2+)(in) + H(+)(in)
REACT:R-GGA-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Gallus gallus)
GO:0008376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Homo sapiens)
GO:0008376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylgalactosaminyltransferase activity
GO:0008376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc transferase activity
REACT:R-RNO-2160492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4I1:FAD oxidises L-Phe to kPPV (Rattus norvegicus)
REACT:R-DME-9667952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 is deacetylated by SIRT2 (Drosophila melanogaster)
GO:0009392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-anhydromuramoyl-L-alanine amidase activity
REACT:R-PFA-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Plasmodium falciparum)
GO:0103078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercitrin + UDP-beta-L-rhamnose = H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP
GO:0103078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity
REACT:R-RNO-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Rattus norvegicus)
REACT:R-RNO-194079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Rattus norvegicus)
GO:0016640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor
GO:0016640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a cytochrome as acceptor"
GO:0016640	skos:prefLabel	"With a cytochrome as acceptor"
RHEA:47929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + H2O + NADP(+) => (2S)-3-sulfolactate + 2 H(+) + NADPH
RHEA:64511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine
REACT:R-GGA-5218836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2beta binds alphaVbeta3 (Gallus gallus)
RHEA:69927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(out) + Na(+)(out) = adenosine(in) + Na(+)(in)
RHEA:62889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + lactose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)
RHEA:43041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + hexadecasphinganine => CoA + H(+) + N-hexadecanoylhexadecasphinganine
REACT:R-MMU-8944223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type V (Mus musculus)
RHEA:32671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylglucosamine kinase"
RHEA:32671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate
RHEA:32671	skos:altLabel	"UNAG kinase"
RHEA:32671	skos:prefLabel	"UDP-N-acetylglucosamine kinase"
RHEA:20224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + ATP + formate <=> (6S)-10-formyltetrahydrofolate + ADP + phosphate
GO:0042911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acridine transporter activity
GO:0042911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acridine transmembrane transporter activity
RHEA:71897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide => dGTP + NAD(+)
RHEA:48905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-BTA-3769393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ binds p-CBY:CTNNB1 (Bos taurus)
REACT:R-MMU-9696275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds GTP (Mus musculus)
REACT:R-GGA-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Gallus gallus)
RHEA:72497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + prostaglandin E2(in) => glutarate(in) + prostaglandin E2(out)
REACT:R-SSC-203712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS associates with Caveolin-1 (Sus scrofa)
REACT:R-XTR-9018858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Xenopus tropicalis)
RHEA:72404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + urate(in) => 2-oxoglutarate(in) + urate(out)
REACT:R-HSA-2176475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
REACT:R-SSC-70577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Sus scrofa)
REACT:R-BTA-75823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Bos taurus)
REACT:R-RNO-193401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
REACT:R-RNO-9690449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 bind S1P (Rattus norvegicus)
RHEA:29231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate(in) = cyanate(out)
RHEA:72105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(in) + O-propanoyl-(R)-carnitine(in) => Na(+)(out) + O-propanoyl-(R)-carnitine(out)
RHEA:19144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol <=> 11-cis-retinol
RHEA:43385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginyl-[protein] => ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]
REACT:R-SSC-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Sus scrofa)
REACT:R-SSC-71588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Sus scrofa)
RHEA:70114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-75885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Schizosaccharomyces pombe)
RHEA:20822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + H(+) + sulfate => choline sulfate + H2O
REACT:R-CFA-8866941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MID1IP1 binds THRSP (Canis familiaris)
RHEA:25406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-3-methyl-2-oxopentanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate
REACT:R-BTA-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)
REACT:R-RNO-158311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Rattus norvegicus)
REACT:R-CFA-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Canis familiaris)
REACT:R-HSA-5638007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 activates the GTPase activity of ARL3 (Homo sapiens)
GO:0047757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dermatan-sulfate 5-epimerase activity
GO:0047757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin-D-glucuronate 5-epimerase activity
GO:0047757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin-glucuronate 5-epimerase activity
GO:0047757	skos:altLabel	"polyglucuronate 5-epimerase"
GO:0047757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin 4'-sulfate = dermatan 4'-sulfate
GO:0047757	skos:altLabel	"dermatan-sulfate 5-epimerase"
GO:0047757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chondroitin-glucuronate 5-epimerase"
GO:0047757	skos:prefLabel	"chondroitin-glucuronate 5-epimerase"
GO:0047757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyglucuronate 5-epimerase activity
GO:0047757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urunosyl C-5 epimerase activity
GO:0047757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chondroitin D-glucuronosyl 5-epimerase activity
REACT:R-HSA-192422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular PTL:colipase (Homo sapiens)
RHEA:57771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrotoluene + NADH + O2 <=> 3-methylcatechol + NAD(+) + nitrite
RHEA:45559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine
REACT:R-RNO-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Rattus norvegicus)
REACT:R-HSA-6784189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind LIFR (Homo sapiens)
RHEA:68704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) = 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-HSA-5678517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCB11 does not transport bile salts from cytosol to extracellular region (Homo sapiens)
REACT:R-RNO-5359451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from SAM to NAM to form MNA (Rattus norvegicus)
RHEA:35750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> 7-epizingiberene + diphosphate
RHEA:20301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)
RHEA:20301	skos:altLabel	"arginine translase"
RHEA:20301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginine--tRNA ligase"
RHEA:20301	skos:altLabel	"arginyl-tRNA synthetase"
RHEA:20301	skos:prefLabel	"arginine--tRNA ligase"
REACT:R-DRE-8875320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 GEFs exchange GTP for GDP on RAB5 (Danio rerio)
REACT:R-HSA-5657642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA (Homo sapiens)
REACT:R-BTA-400183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA:RXRA binds Corepressors of PPARA (Bos taurus)
RHEA:59096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monoglucosyl-enterobactin + UDP-alpha-D-glucose = diglucosyl-enterobactin + H(+) + UDP
GO:0019177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroneopterin triphosphate pyrophosphohydrolase activity
RHEA:50034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine => H2O + hexadecanoyl-CoA
RHEA:35144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA
RHEA:34031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-N-acetylparomamine + H2O = acetate + paromamine
RHEA:34031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-N-acetylparomamine deacetylase"
RHEA:34031	skos:prefLabel	"2'-N-acetylparomamine deacetylase"
REACT:R-GGA-266089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Discoidal HDL binds membrane-associated free cholesterol (Gallus gallus)
REACT:R-HSA-1497878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) (Homo sapiens)
RHEA:28492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + K(+)(out) => H(+)(in) + K(+)(in)
REACT:R-DRE-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Danio rerio)
REACT:R-MMU-8854588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 (OATL1) binds ATG8 homologues (Mus musculus)
REACT:R-CFA-421416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proglucagon translocates from the ER Lumen to secretory granules (Canis familiaris)
RHEA:66787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) <=> 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]
RHEA:71579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out)
REACT:R-DRE-9018895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Danio rerio)
RHEA:27864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + phosphate => 3'-GMP + H2O
REACT:R-HSA-8952716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 binds Ragulator:Rag dimers (Homo sapiens)
REACT:R-MMU-450088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 tetramer binds 4xATP (Mus musculus)
REACT:R-CFA-3785711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Telomere shortening during replicative exhaustion (Canis familiaris)
REACT:R-XTR-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Xenopus tropicalis)
RHEA:48171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine <=> N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate
RHEA:62909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nor-toralactone + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toralactone
GO:0102839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity
REACT:R-SPO-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Schizosaccharomyces pombe)
REACT:R-CFA-1475414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)
REACT:R-GGA-1358798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 binds neuregulin-activated ERBB3 (Gallus gallus)
REACT:R-GGA-909732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT2 (Gallus gallus)
RHEA:43636	skos:prefLabel	"protein acetyllysine N-acetyltransferase"
RHEA:43636	skos:altLabel	"protein lysine deacetylase"
RHEA:43636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein acetyllysine N-acetyltransferase"
RHEA:43636	skos:altLabel	"NAD(+)-dependent protein deacetylase"
RHEA:43636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:69899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + thymidine(out) = 2 Na(+)(in) + thymidine(in)
REACT:R-PFA-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Plasmodium falciparum)
GO:0035460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-ascorbate 6-phosphate = 3-dehydro-L-gulonate 6-phosphate
GO:0035460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate 6-phosphate lactonase activity
REACT:R-SSC-8854604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D16 accelerates GTP hydrolysis by RAB4A (Sus scrofa)
REACT:R-MMU-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Mus musculus)
RHEA:12403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + H2O <=> NH4(+) + nicotinate beta-D-ribonucleotide
GO:0052920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-2-methylbutanenitrile lyase activity
RHEA:41719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine
RHEA:21935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine <=> homoserine lactone + S-methyl-5'-thioadenosine
REACT:R-DME-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)
RHEA:67761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-HSA-2466822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective OPN1LW causes BCM (Homo sapiens)
GO:0034531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity
REACT:R-GGA-933533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of p-IRF7 (Gallus gallus)
RHEA:52627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate
RHEA:65834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O
REACT:R-HSA-2980720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEK9 binds NEK6/NEK7 in the cytosol (Homo sapiens)
RHEA:36645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + questin + S-adenosyl-L-homocysteine => emodin + S-adenosyl-L-methionine
REACT:R-DRE-77325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Danio rerio)
REACT:R-SSC-8850539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GNB5:RGS dimers from CCT/TRiC (Sus scrofa)
REACT:R-BTA-9023884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to TGFA promoter (Bos taurus)
RHEA:12017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-germacrene D + diphosphate
RHEA:58152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + phosphonoacetaldehyde = 2 H(+) + NADH + phosphonoacetate
RHEA:43230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine => L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine
REACT:R-RNO-8985929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Rattus norvegicus)
REACT:R-SPO-170825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase [nucleoplasm] => glucokinase [cytosol] (Schizosaccharomyces pombe)
GO:0031756	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Edg-3 sphingosine 1-phosphate receptor ligand
GO:0031756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edg-3 sphingosine 1-phosphate receptor binding
REACT:R-RNO-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Rattus norvegicus)
REACT:R-RNO-446684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)
GO:0019776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APG8 ligase activity
GO:0019776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APG8 conjugating enzyme activity
GO:0019776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Atg8 conjugating enzyme activity
GO:0019776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Homo sapiens)
GO:0019776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Atg8 ligase activity
REACT:R-XTR-264871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin B1 (Xenopus tropicalis)
GO:0072518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rho-associated protein kinase activity
GO:0072518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rho-dependent protein serine/threonine kinase activity
GO:0072518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK kinase activity
REACT:R-SSC-8877451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MON1:CCZ1 exchanges GTP for GDP on RAB7 (Sus scrofa)
REACT:R-SSC-417820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 receptor can bind to LPA (Sus scrofa)
REACT:R-HSA-9748983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6MP, forming 6MeMP (Homo sapiens)
RHEA:65503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine
REACT:R-RNO-9627350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) binds XIAP (Rattus norvegicus)
RHEA:28809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinylglycine + L-glutamate => glutathione + H2O
REACT:R-XTR-983425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Xenopus tropicalis)
REACT:R-HSA-8985153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OASL binds DDX58 (Homo sapiens)
REACT:R-HSA-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Homo sapiens)
RHEA:31673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine
REACT:R-DRE-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Danio rerio)
REACT:R-DME-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Drosophila melanogaster)
REACT:R-MMU-442387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP8 mediates zinc influx into cells (Mus musculus)
REACT:R-HSA-70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate + H2O => 4-imidazolone-5-propionate (Homo sapiens)
REACT:R-XTR-8873929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates STARD10 (Xenopus tropicalis)
GO:0010327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity
GO:0010327	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexenol acetyltransferase
RHEA:27418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome] + H2O + nicotinate => 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)
RHEA:13978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine => NH4(+) + pyruvate
RHEA:49132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in tRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine
GO:0047948	skos:altLabel	"glutaryl-CoA synthetase"
GO:0047948	skos:prefLabel	"glutarate--CoA ligase"
GO:0047948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutarate--CoA ligase"
GO:0047948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaryl-CoA synthetase activity
GO:0047948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate-CoA ligase activity
GO:0047948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutarate:CoA ligase (ADP-forming)
GO:0047948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + glutarate = ADP + glutaryl-CoA + phosphate
GO:0047948	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaryl coenzyme A synthetase activity
REACT:R-MMU-9629679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A inhibitors bind PDE3A (Mus musculus)
EC:1.8.98.-	skos:prefLabel	"With other, known, acceptors"
EC:1.8.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
REACT:R-BTA-159046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Bos taurus)
REACT:R-DRE-5340195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4 binds DCA, CDCA, LCHA (Danio rerio)
REACT:R-CFA-6798373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates DYRK2 (Canis familiaris)
RHEA:21354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+) => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2
RHEA:41756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-HSA-8940032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TWIST1 binds the RUNX2 gene promoter (Homo sapiens)
REACT:R-RNO-448427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 binds Interleukin-27 receptor (Rattus norvegicus)
GO:0050284	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:sinapic acid glucosyltransferase activity
GO:0050284	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-sinapate glucosyltransferase activity
GO:0050284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinapate 1-glucosyltransferase activity
GO:0050284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + UDP-alpha-D-glucose = 1-O-(trans-sinapoyl)-beta-D-glucose + UDP
GO:0050284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sinapate 1-glucosyltransferase"
GO:0050284	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity
GO:0050284	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:sinapate D-glucosyltransferase activity
GO:0050284	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:sinapate D-glucosyltransferase activity
GO:0050284	skos:prefLabel	"sinapate 1-glucosyltransferase"
REACT:R-DRE-9668023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPST1,2 transfer SO4(2-) from PAPS to FVIII (Danio rerio)
RHEA:45233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)
RHEA:22143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a nucleoside 5'-phosphate + H2O <=> a nucleoside + phosphate
RHEA:46673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldosterone + H(+) + NADPH => 5beta-dihydroaldosterone + NADP(+)
REACT:R-CFA-194642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Canis familiaris)
REACT:R-DRE-448963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of MyoD:E protein with MEF2 (Danio rerio)
REACT:R-GGA-5669035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF11 binds TNFRSF11A, B (Gallus gallus)
REACT:R-RNO-392752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by CK-II (Rattus norvegicus)
REACT:R-DRE-449937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Danio rerio)
RHEA:16338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9729725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 (Homo sapiens)
RHEA:57493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + oxaloacetate + propanoyl-CoA => 2-methylcitrate + CoA + H(+)
REACT:R-CFA-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Canis familiaris)
REACT:R-MMU-388814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds CD28 (Mus musculus)
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,4-glucan 4-glucanohydrolase activity
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-(1,4)-beta-D-glucanase activity
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1->4-glucan hydrolase activity
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-beta-D-glucan glucanohydrolase activity
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-beta-1,4-glucanase activity
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-(1->4)-beta-D-glucanase activity
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-1,4-beta-D-glucanase activity
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endo-1,4-beta-glucanase activity
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,4-glucanase activity
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan endo-1,4-beta-glucosidase activity
GO:0052859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,4-glucan hydrolase activity
REACT:R-DRE-8851929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Danio rerio)
RHEA:34384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP
RHEA:12704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate
RHEA:14468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidinol phosphate <=> L-histidinol + phosphate
RHEA:15078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-[(R)-pantothenoyl]-L-cysteine => (R)-pantetheine + CO2
REACT:R-CFA-937034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino (Canis familiaris)
RHEA:49099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine
RHEA:63036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanamide = NH4(+) + octadecanoate
RHEA:71342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-tyrosine(out) + 2 Na(+)(out) <=> chloride(in) + L-tyrosine(in) + 2 Na(+)(in)
REACT:R-HSA-9674397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Imatinib-resistant PDGFR mutants don't bind imatinib (Homo sapiens)
REACT:R-PFA-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Plasmodium falciparum)
REACT:R-HSA-6787567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) (Homo sapiens)
REACT:R-BTA-2161701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by HPGDS (Bos taurus)
REACT:R-XTR-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Xenopus tropicalis)
RHEA:18856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + tartrate <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH
REACT:R-XTR-9671145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKC1 binds SHQ1 (Xenopus tropicalis)
GO:0102477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity
RHEA:23249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + S-adenosyl-L-methionine => 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Gallus gallus)
RHEA:29978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxycytidine(in) + H(+)(in) <=> 2'-deoxycytidine(out) + H(+)(out)
RHEA:37751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-trans-aconitate = 2-methyl-cis-aconitate
RHEA:53804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholoyl-CoA + ursodeoxycholate = allodeoxycholate + ursodeoxycholoyl-CoA
RHEA:19285	skos:prefLabel	"phosphatidylcholine--dolichol O-acyltransferase"
RHEA:19285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylcholine--dolichol O-acyltransferase"
RHEA:19285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol = a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol
REACT:R-DDI-8987218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Dictyostelium discoideum)
RHEA:50976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D2(out) = prostaglandin D2(in)
REACT:R-SPO-110219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by TDG glycosylase (Schizosaccharomyces pombe)
REACT:R-DRE-2130619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosomal vesicle coat assembly (Danio rerio)
REACT:R-XTR-421007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endocytosis of Ca impermeable AMPA receptors (Xenopus tropicalis)
RHEA:65252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 6-hydroxymellein = diphosphate + verruculide C
REACT:R-SSC-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Sus scrofa)
RHEA:62854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate
RHEA:13682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-193424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
REACT:R-DRE-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-RNO-193709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)
REACT:R-SSC-195664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Sus scrofa)
GO:0039660	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	viral matrix protein
GO:0039660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of virion
RHEA:71793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate(out) + H(+)(out) => (R)-lactate(in) + H(+)(in)
RHEA:26419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal
REACT:R-MMU-8985966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1 binds p-Y705-STAT3 (Mus musculus)
REACT:R-XTR-9020278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Xenopus tropicalis)
RHEA:35928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	paromamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP
RHEA:52041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cystine => 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine
RHEA:10827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NADP(+) <=> H(+) + NADPH + oxaloacetate
REACT:R-BTA-6782208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Bos taurus)
RHEA:45352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-epoxyoctadecanoate + H2O = 9,10-dihydroxyoctadecanoate
GO:1902271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D3 vitamins binding
RHEA:57162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2
REACT:R-RNO-5218824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds FYN (Rattus norvegicus)
RHEA:65466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutyl butanoate + CoA => 2-methylbutan-1-ol + butanoyl-CoA
RHEA:70036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol
REACT:R-PFA-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Plasmodium falciparum)
RHEA:25591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate + NADP(+) <=> (S)-oxalosuccinate + H(+) + NADPH
REACT:R-MMU-450173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 induces oligomerisation of TRAF6 (Mus musculus)
REACT:R-HSA-5696822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B15 reduces EST17b to E1 (Homo sapiens)
RHEA:35672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-5'-oxoaverantin + H(+) => (1'S,5'S)-averufin + H2O
RHEA:66318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O
RHEA:63308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate
EC:1.5.1.53	skos:altLabel	"N(5),10-methylenetetrahydrofolate reductase"
EC:1.5.1.53	skos:altLabel	"5,10-methylenetetrahydrofolate reductase (FADH2)"
EC:1.5.1.53	skos:altLabel	"5,10-methylenetetrahydrofolate reductase (NADPH)"
EC:1.5.1.53	skos:altLabel	"5,10-CH2-H4folate reductase"
EC:1.5.1.53	skos:prefLabel	"methylenetetrahydrofolate reductase (NADPH)"
EC:1.5.1.53	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylenetetrahydrofolate reductase (NADPH)"
RHEA:13376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-mimosine <=> 3-hydroxy-4H-pyrid-4-one + L-serine
REACT:R-DDI-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Dictyostelium discoideum)
RHEA:43006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + CO2 + NH4(+) => H(+) + O-carbamoyl-L-serine
EC:3.4.17.2	skos:altLabel	"protaminase"
EC:3.4.17.2	skos:prefLabel	"carboxypeptidase B"
EC:3.4.17.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxypeptidase B"
REACT:R-HSA-1368119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CLOCK (Homo sapiens)
REACT:R-DME-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Drosophila melanogaster)
GO:0070119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNTF binding
GO:0070119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ciliary neurotrophic factor binding
REACT:R-XTR-2396007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3 is phosphorylated by TBK1 (Xenopus tropicalis)
RHEA:46353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + H2O => 3-hydroxydecanoyl-CoA
RHEA:61414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine => ATP + N-(D-erythrulosyl)-cadaverine
RHEA:28976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-asparagine(in) => H(+)(in) + L-asparagine(out)
REACT:R-CEL-166214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion flip-flops to the opposite surface (Caenorhabditis elegans)
GO:0052591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + ubiquinone-8 = dihydroxyacetone phosphate + ubiquinol-8
GO:0052591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
REACT:R-RNO-5669012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA binds EDAR (Rattus norvegicus)
RHEA:58505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate
REACT:R-XTR-1638104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Xenopus tropicalis)
REACT:R-CFA-389086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha/beta receptors (Canis familiaris)
RHEA:38504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)
REACT:R-GGA-9013004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the ER membrane (Gallus gallus)
RHEA:64568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = ilicicolin H
RHEA:56122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-heptaprenylphenol + H(+) + NADPH + O2
REACT:R-BTA-5625717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PKN1 binds androgen receptor (AR) (Bos taurus)
REACT:R-BTA-9749971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Bos taurus)
RHEA:32256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)
REACT:R-HSA-1474213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP1,8,9,13 (Homo sapiens)
REACT:R-SSC-8937191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Sus scrofa)
RHEA:45005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + 2,6-dimethylheptanoyl-CoA => CoA + O-2,6-dimethylheptanoyl-(R)-carnitine
REACT:R-RNO-6785933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT8 transfers Gal from UDP-Gal to CERA (Rattus norvegicus)
REACT:R-DRE-5218952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Danio rerio)
REACT:R-CEL-9701565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDACs deacetylate p-STAT3 dimers (Caenorhabditis elegans)
REACT:R-GGA-419157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate (Gallus gallus)
RHEA:65804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine
REACT:R-GGA-9710101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP4, CASP5 cleave GSDMD (Gallus gallus)
REACT:R-RNO-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Rattus norvegicus)
REACT:R-HSA-9754518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 3a tetramer binds to CAV1 (Homo sapiens)
RHEA:26387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal => all-trans-8'-apo-beta-carotenal + O2
REACT:R-BTA-5685605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF7 binds SLAMF7 (Bos taurus)
REACT:R-MMU-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Mus musculus)
REACT:R-BTA-5654623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS3 (Bos taurus)
REACT:R-MMU-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Mus musculus)
RHEA:20975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine
REACT:R-DDI-9033235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)
RHEA:20759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + D-threo-isocitrate <=> 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA
RHEA:42974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin + ethanolamine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
RHEA:24791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O
REACT:R-MMU-8849463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates SFPQ (Mus musculus)
GO:0052764	skos:prefLabel	"oligo-alginate lyase"
GO:0052764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligo-alginate lyase"
GO:0052764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-oligoalginate lyase activity
GO:0052764	skos:altLabel	"oligoalginate lyase"
GO:0052764	skos:altLabel	"exo-oligoalginate lyase"
REACT:R-RNO-5654640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
REACT:R-DRE-9010815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLITs bind keratan sulfate (Danio rerio)
RHEA:47354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic alcohol + H(+) + hexanoate => a hexanoate ester + H2O
RHEA:23333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + GTP => (2R)-3-phospho-glyceroyl phosphate + GDP
REACT:R-RNO-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Rattus norvegicus)
RHEA:18949	skos:altLabel	"CYP725A2"
RHEA:18949	skos:prefLabel	"taxane 13alpha-hydroxylase"
RHEA:18949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol
RHEA:18949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taxane 13alpha-hydroxylase"
RHEA:61953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate
REACT:R-XTR-8875576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK,CRKL recruits RAC1 GEF to activated MET (Xenopus tropicalis)
RHEA:30786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + H2O + NAD(+) <=> (R)-glycerate + 2 H(+) + NADH
GO:0043185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fms-like-tyrosine kinase (Flt)-4 binding
GO:0043185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF receptor 3 binding
GO:0043185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vascular endothelial growth factor receptor 3 binding
GO:0043185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR 3 binding
REACT:R-HSA-5679255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPI2 binds ATG12:ATG5:ATG16L (Homo sapiens)
REACT:R-GGA-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Gallus gallus)
RHEA:24272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)
RHEA:31048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonate semialdehyde + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA
REACT:R-DRE-170126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin B1 in the CRS domain (Danio rerio)
RHEA:69548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-phospho-L-serine = CO2 + phosphoethanolamine
RHEA:55137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanine + H(+) => D-alanyl-5'-AMP + diphosphate
REACT:R-MMU-209925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIT and MIT combine to form triiodothyronine (Mus musculus)
REACT:R-XTR-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Xenopus tropicalis)
REACT:R-RNO-5658231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs stimulate RAS GTPase activity (Rattus norvegicus)
REACT:R-XTR-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)
REACT:R-RNO-8943007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Rattus norvegicus)
REACT:R-HSA-6810392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMEM55B translocates to the nucleus (Homo sapiens)
REACT:R-XTR-168947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand binds to TLR10 (Xenopus tropicalis)
RHEA:56634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-cineole + diphosphate => H2O + neryl diphosphate
RHEA:55111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxononanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxynonanoyl-[ACP] + NADP(+)
RHEA:66562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+) => (R)-noradrenaline + L-glutaminyl-[protein]
EC:3.9.-.-	skos:prefLabel	"Acting on phosphorus-nitrogen bonds"
EC:3.9.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on phosphorus-nitrogen bonds"
REACT:R-SCE-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Saccharomyces cerevisiae)
RHEA:50971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA(Ala) + H(+) + H2O <=> inosine(37) in tRNA(Ala) + NH4(+)
RHEA:42697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hercynylselenocysteine => NH4(+) + pyruvate + selnoneine thione
RHEA:42759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9702570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KW2449-resistant FLT3 mutants don't bind KW2449 (Homo sapiens)
REACT:R-DRE-5333678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPNEs bind PL (Danio rerio)
REACT:R-GGA-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Gallus gallus)
RHEA:55343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol <=> 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA
GO:0043893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation-acetate symporter activity
GO:0043893	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acetate permease
GO:0043893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate/cation symporter activity
GO:0043893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate:cation symporter activity
GO:0043893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate-cation symporter activity
GO:0043893	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ActP
GO:0043893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation:acetate symporter activity
GO:0043893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation/acetate symporter activity
REACT:R-RNO-8874201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3L3 (Rattus norvegicus)
GO:0018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylphosphate carboxylase activity
RHEA:18909	skos:altLabel	"halogenated phenol O-methyltransferase"
RHEA:18909	skos:altLabel	"trichlorophenol O-methyltransferase"
RHEA:18909	skos:prefLabel	"chlorophenol O-methyltransferase"
RHEA:18909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorophenol O-methyltransferase"
RHEA:18909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trichlorophenol + S-adenosyl-L-methionine = 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine
REACT:R-HSA-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Homo sapiens)
RHEA:17958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate => H2O + propynoate
GO:0060724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in epidermal growth factor receptor signalling pathway
GO:0060724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in epidermal growth factor receptor signaling pathway
RHEA:45207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol <=> H2O + methyl-Co(III)-[methanol-specific corrinoid protein]
REACT:R-DRE-977301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histidine is decarboxylated to histamine (Danio rerio)
REACT:R-MMU-350578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO1 interaction with ODC (Mus musculus)
REACT:R-SSC-74101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerization of 11c-retinyl to at-retinyl (Sus scrofa)
RHEA:13921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-8870489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA4,(5,6) bind PI3P (Mus musculus)
REACT:R-RNO-180073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Rattus norvegicus)
REACT:R-MMU-593685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Netrin-4 binds DCC/UNC5A (Mus musculus)
RHEA:27713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + guanosine <=> ADP + GMP + H(+)
REACT:R-MMU-8865774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLLs polyglutamylate tubulin (Mus musculus)
REACT:R-CEL-1605717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Caenorhabditis elegans)
RHEA:34850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromonapterin + H(+) + NADPH <=> 5,6,7,8-tetrahydromonapterin + NADP(+)
REACT:R-BTA-5578712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 binds AGO2:miRNA (Bos taurus)
REACT:R-BTA-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Bos taurus)
REACT:R-DME-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)
GO:0009824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity
GO:0009824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytokinin synthase activity
GO:0009824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP dimethylallyltransferase activity
GO:0009824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate:AMP dimethylallyltransferase activity
GO:0009824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylate dimethylallyltransferase activity
GO:0009824	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	isopentenyltransferase activity
GO:0009824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylate isopentenyltransferase activity
GO:0009824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity
REACT:R-HSA-9769949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage (Homo sapiens)
RHEA:62366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMN-N(5)-peroxide + thymine
REACT:R-CFA-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Canis familiaris)
REACT:R-DDI-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Dictyostelium discoideum)
REACT:R-HSA-1655831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 translocates to the nucleus (Homo sapiens)
RHEA:40329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP
REACT:R-HSA-443418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b signaling involves c-Src (Homo sapiens)
RHEA:31736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocholan-24-oyl-CoA + NAD(+) => 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
RHEA:60334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine
RHEA:34025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+)
RHEA:39574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:34998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnose(in) <=> L-rhamnose(out)
REACT:R-XTR-4755479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NFKB2 with SUMO1 (Xenopus tropicalis)
RHEA:33295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Drosophila melanogaster)
REACT:R-GGA-4551679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO2 (Gallus gallus)
REACT:R-DRE-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Danio rerio)
GO:0031807	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H1 histamine receptor ligand
GO:0031807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H1 histamine receptor binding
RHEA:64646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyl propanoate + CoA => butan-1-ol + propanoyl-CoA
RHEA:33692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate
EC:1.14.14.154	skos:prefLabel	"sterol 14alpha-demethylase"
EC:1.14.14.154	skos:altLabel	"cytochrome P450 51"
EC:1.14.14.154	skos:altLabel	"CYP51"
EC:1.14.14.154	skos:altLabel	"lanosterol 14alpha-demethylase"
EC:1.14.14.154	skos:altLabel	"obtusufoliol 14-demethylase"
EC:1.14.14.154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sterol 14alpha-demethylase"
EC:1.14.14.154	skos:altLabel	"lanosterol 14-demethylase"
RHEA:16220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arabinono-1,4-lactone <=> H(+) + L-arabinonate
REACT:R-RNO-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Rattus norvegicus)
GO:0017188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:L-aspartate N-acetyltransferase activity
GO:0017188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate acetyltransferase activity
GO:0017188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate N-acetyltransferase activity
GO:0017188	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate N-acetyltransferase activity
RHEA:57775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite
REACT:R-RNO-2203480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLEC11 binds ligands (Rattus norvegicus)
REACT:R-SSC-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Sus scrofa)
RHEA:18927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucurono-3,6-lactone + H(+) + NADPH => L-gulono-1,4-lactone + NADP(+)
RHEA:48619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene D4 <=> glycine + leukotriene E4
RHEA:69514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + N-acetyl-D-galactosaminate => H2O + N-acetyl-D-galactosamine + O2
RHEA:17929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+)
RHEA:17929	skos:prefLabel	"ceramide kinase"
RHEA:17929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ceramide kinase"
RHEA:17929	skos:altLabel	"acylsphingosine kinase"
REACT:R-DRE-5635855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Danio rerio)
REACT:R-SSC-202328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PKC theta to plasma membrane (Sus scrofa)
REACT:R-DME-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Drosophila melanogaster)
REACT:R-GGA-437300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC31A1 transports Cu2+ from extracellular region to cytosol (Gallus gallus)
RHEA:72949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(in) + 2 Na(+)(in) => acetate(out) + 2 Na(+)(out)
REACT:R-GGA-373087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR6 binds CCL20 ligand (Gallus gallus)
REACT:R-HSA-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Homo sapiens)
RHEA:53178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine
REACT:R-RNO-74993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Rattus norvegicus)
RHEA:17619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + leukotriene A4 => leukotriene C4
REACT:R-MMU-390886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH4 binds Hist (Mus musculus)
GO:0097159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organic cyclic compound binding
REACT:R-CEL-2730862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of LYN kinase (Caenorhabditis elegans)
REACT:R-BTA-210283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and PLC gamma1 (Bos taurus)
REACT:R-DRE-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Danio rerio)
REACT:R-BTA-8937177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD binds ARNT (Bos taurus)
REACT:R-RNO-6788392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)
REACT:R-SCE-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)
REACT:R-BTA-376200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A10-mediated uptake of small neutral amino acids (Bos taurus)
REACT:R-HSA-9013157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds effectors at the plasma membrane (Homo sapiens)
REACT:R-SCE-1855194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)
REACT:R-MMU-1676149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Mus musculus)
RHEA:47844	skos:altLabel	"TMP pyrophosphorylase"
RHEA:47844	skos:altLabel	"thiamine-phosphate diphosphorylase"
RHEA:47844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate
RHEA:47844	skos:altLabel	"TMP diphosphorylase"
RHEA:47844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiamine phosphate synthase"
RHEA:47844	skos:altLabel	"thiamine-phosphate synthase"
RHEA:47844	skos:altLabel	"thiamine-phosphate pyrophosphorylase"
RHEA:47844	skos:prefLabel	"thiamine phosphate synthase"
REACT:R-XTR-193073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Xenopus tropicalis)
REACT:R-SPO-112434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF complex  (Schizosaccharomyces pombe)
REACT:R-XTR-8853792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET tyrosine phosphorylation (Xenopus tropicalis)
REACT:R-CFA-5654597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Canis familiaris)
RHEA:47904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-(acetyl)-sphing-4-enine = ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate
REACT:R-GGA-2028555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Gallus gallus)
REACT:R-HSA-6789524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of IL4,IL13-downregulated extracellular genes (Homo sapiens)
GO:0034611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligoribonucleotidase activity
GO:0034611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA oligonucleotidase activity
REACT:R-HSA-9027625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3 (Homo sapiens)
REACT:R-CFA-9734535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Canis familiaris)
REACT:R-BTA-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Bos taurus)
RHEA:40207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenedioyl-CoA + H2O = (3S)-hydroxytetradecanedioyl-CoA
RHEA:69110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-kynurenine
RHEA:29234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate(in) <=> cyanate(out)
REACT:R-SCE-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Saccharomyces cerevisiae)
RHEA:28923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-phenylalanine(in) = H(+)(out) + L-phenylalanine(out)
RHEA:61879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
RHEA:12182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine
REACT:R-DRE-5654147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PLCG1 (Danio rerio)
RHEA:19343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octan-1-ol + 2 oxidized [rubredoxin] => 2 H(+) + O2 + octane + 2 reduced [rubredoxin]
RHEA:34986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate(in) <=> sulfate(out)
RHEA:45173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-SSC-3222128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOC2L binds TP53 (Sus scrofa)
REACT:R-CEL-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Caenorhabditis elegans)
RHEA:37709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA
REACT:R-SPO-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Schizosaccharomyces pombe)
REACT:R-DDI-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Dictyostelium discoideum)
REACT:R-XTR-1467466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA4 mediates atRAL transport (Xenopus tropicalis)
REACT:R-BTA-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Bos taurus)
RHEA:44832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + tetradecanoyl-CoA = CoA + O-tetradecanoyl-(R)-carnitine
REACT:R-DRE-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Danio rerio)
GO:0034557	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-hydroxylaminobenzoate nitroreductase activity
GO:0034557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxylaminobenzoate reductase activity
RHEA:68038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+) => (S)-cystathionine ketimine + 2 H(+) + NADPH
RHEA:38497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,3-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O
REACT:R-SSC-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)
REACT:R-HSA-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Homo sapiens)
GO:0032035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin II tail binding
REACT:R-HSA-9624976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3 binds CAV1 gene promoter (Homo sapiens)
REACT:R-MMU-8944229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type IX (Mus musculus)
REACT:R-BTA-9014424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the phagocytic vesicle membrane (Bos taurus)
REACT:R-DME-9709406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO binds to Cytochrome c oxidase (Drosophila melanogaster)
RHEA:45942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA
RHEA:48230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]
GO:0002161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoacyl-tRNA hydrolysis activity
GO:0002161	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amino acid proofreading activity
GO:0002161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoacyl-tRNA editing activity
RHEA:38187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-8952639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Danio rerio)
RHEA:70094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + o-quinone methide <=> hydroxyclavatol ethyl ether
REACT:R-SSC-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Sus scrofa)
GO:0016782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring sulfur-containing groups"
GO:0016782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring sulphur-containing groups
GO:0016782	skos:prefLabel	"Transferring sulfur-containing groups"
RHEA:17570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + NADP(+) => 1,2-dehydroreticuline + H(+) + NADPH
REACT:R-SSC-139855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X1-mediated entry of Ca++ from plasma (Sus scrofa)
GO:0102518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-eicosenoate 14-hydroxylase activity
REACT:R-DRE-909722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-STAT2:p-STAT1 dimer (Danio rerio)
REACT:R-BTA-6783530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gp130:JAKs bind CNTFR (Bos taurus)
REACT:R-CEL-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Caenorhabditis elegans)
REACT:R-PFA-350598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arginine<=>Agmatine+CO2 (Plasmodium falciparum)
GO:0102128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chalcone synthase activity
RHEA:26452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + succinyl-CoA => CoA + NADP(+) + succinate semialdehyde
RHEA:39839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA
REACT:R-HSA-381706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R:GLP1 activates G(s) (Homo sapiens)
REACT:R-SSC-2990842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO2 (Sus scrofa)
RHEA:72732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose(in) + UMP(out) => UDP-alpha-D-glucose(out) + UMP(in)
RHEA:11123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanate + 3 H(+) + hydrogencarbonate <=> 2 CO2 + NH4(+)
REACT:R-SSC-8987007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimerizes (Sus scrofa)
REACT:R-XTR-606326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HJURP:CENPA complex localizes to the centromere (Xenopus tropicalis)
REACT:R-SSC-3341277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
REACT:R-CFA-174438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate on the C-strand (Canis familiaris)
REACT:R-BTA-5610763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Bos taurus)
RHEA:23375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
GO:0102974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxyversicolorone reductase activity
REACT:R-PFA-429036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A9 transports Fru, Glc, urate (Plasmodium falciparum)
RHEA:63630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + hexadecanoyl-[ACP] => ATP + hexadecanoate + holo-[ACP]
REACT:R-XTR-1675974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Xenopus tropicalis)
REACT:R-CEL-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Caenorhabditis elegans)
RHEA:55253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
REACT:R-GGA-75856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation Before Second Transition (Gallus gallus)
RHEA:50647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3-methylsulfanyl)propylmalate <=> 3-(3-methylsulfanyl)propylmalate
RHEA:69011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-aspartate + 3 NADPH + 3 O2 <=> 2-nitrobutanedioate + 4 H2O + 3 NADP(+)
GO:0019194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbose porter activity
GO:0019194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbose transmembrane transporter activity
GO:0005297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline:proton symporter activity
GO:0005297	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogen/proline transporter
REACT:R-GGA-265968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with BRCA1 (Gallus gallus)
GO:0033945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oligoxyloglucan reducing-end-specific cellobiohydrolase activity
GO:0033945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligoxyloglucan reducing-end cellobiohydrolase activity
GO:0033945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligoxyloglucan reducing end-specific cellobiohydrolase activity
REACT:R-GGA-1299297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of THIK (Gallus gallus)
RHEA:51195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH
RHEA:19809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ureidoglycolate amidohydrolase"
RHEA:19809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + 2 H(+) + H2O = CO2 + glyoxylate + 2 NH4(+)
RHEA:19809	skos:altLabel	"ureidoglycolate hydrolase"
RHEA:19809	skos:prefLabel	"ureidoglycolate amidohydrolase"
REACT:R-HSA-9013069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)
RHEA:23536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate
RHEA:52738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+) => (Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate
REACT:R-BTA-936951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to activated TLR4 complex (Bos taurus)
REACT:R-HSA-5661117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Homo sapiens)
REACT:R-HSA-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Homo sapiens)
REACT:R-DDI-6807118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)
REACT:R-GGA-3341397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)
REACT:R-MMU-996755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFPM proteins bind GATA proteins (Mus musculus)
GO:0004853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	porphyrinogen decarboxylase activity
GO:0004853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)
GO:0004853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen-III carboxy-lyase activity
GO:0004853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	porphyrinogen carboxy-lyase activity
GO:0004853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uroporphyrinogen III decarboxylase activity
GO:0004853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uroporphyrinogen decarboxylase activity
REACT:R-XTR-4754176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR3-histone H3 (Xenopus tropicalis)
RHEA:30522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H(+) + phosphoenolpyruvate <=> diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine
REACT:R-CFA-5694436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 and MIA3 dissociate from procollagen VII vesicle (Canis familiaris)
RHEA:51618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + dATP + H2O => ATP + formate + H(+)
RHEA:17395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-fumarylpyruvate => 3-maleylpyruvate
REACT:R-BTA-452108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Bos taurus)
RHEA:15223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+) => a CDP-1,2-diacyl-sn-glycerol + H2O
RHEA:55193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 => 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate
EC:3.1.26.11	skos:prefLabel	"ribonuclease Z"
EC:3.1.26.11	skos:altLabel	"tRNase Z"
EC:3.1.26.11	skos:altLabel	"3 tRNase"
EC:3.1.26.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease Z"
EC:3.1.26.11	skos:altLabel	"RNase Z"
EC:3.1.26.11	skos:altLabel	"tRNA 3 endonuclease"
REACT:R-RNO-5159245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Rattus norvegicus)
RHEA:64275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylamine + pyruvate <=> benzaldehyde + L-alanine
REACT:R-SSC-83586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Sus scrofa)
GO:0030941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroplast targeting sequence binding
RHEA:22099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + RNA(n+1) <=> a ribonucleoside 5'-diphosphate + RNA(n)
RHEA:22718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]
GO:0050548	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-feruloyl-CoA hydro-lyase activity
GO:0050548	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)
GO:0050548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-feruloyl-CoA hydratase activity
GO:0050548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA
REACT:R-GGA-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Gallus gallus)
RHEA:51961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylpropanal oxime => 2-methylpropanenitrile + H2O
REACT:R-CEL-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Caenorhabditis elegans)
REACT:R-DRE-8938951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PAX5 (BSAP) (Danio rerio)
REACT:R-CEL-8985981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)
REACT:R-CEL-1604360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP14 (Caenorhabditis elegans)
REACT:R-CFA-170158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Canis familiaris)
REACT:R-DRE-936942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Danio rerio)
REACT:R-BTA-3215251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53INP1 and HIPK2 bind TP53 (Bos taurus)
GO:0043429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO:0043429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity
RHEA:25989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:30543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine + ATP + CoA = (S)-carnitinyl-CoA + ADP + phosphate
REACT:R-SSC-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Sus scrofa)
RHEA:60803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A53 + O2 <=> CO2 + gibberellin A44 + succinate
REACT:R-DRE-8983878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Danio rerio)
REACT:R-CFA-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Canis familiaris)
REACT:R-DRE-2328033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds latent TGF-beta (Danio rerio)
RHEA:21517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopiperitenone => piperitenone
REACT:R-HSA-8987043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22RA1 binds JAK1 (Homo sapiens)
RHEA:68537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate
REACT:R-MMU-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Mus musculus)
REACT:R-BTA-1592387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin binds elastic fibres (Bos taurus)
RHEA:57432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] = 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]
REACT:R-XTR-5654643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)
REACT:R-DRE-5654167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds PLCG1 (Danio rerio)
REACT:R-SSC-5687360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLL or POLM extends aligned DNA DSB ends to fill gaps (Sus scrofa)
RHEA:38709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol
REACT:R-DRE-6786171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 deubiquitination by USP1:WDR48 (Danio rerio)
RHEA:36177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + NADP(+) => 1-O-alkylglycerone 3-phosphate + H(+) + NADPH
RHEA:18346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cis-3-alkyl-4-alkyloxetan-2-one => a cis-alkene + CO2
RHEA:35485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine => 5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine
GO:0004160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetohydroxyacid dehydratase activity
GO:0004160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxy-acid hydro-lyase activity
GO:0004160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroxy acid dehydrase activity
GO:0004160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxyisovalerate dehydratase activity
GO:0004160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha,beta-dihydroxyisovalerate dehydratase activity
GO:0004160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)
GO:0004160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha,beta-dihydroxyacid dehydratase activity
GO:0004160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxy-acid dehydratase activity
GO:0004160	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DHAD
REACT:R-DRE-8847880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYTH proteins bind ARF1:GTP (Danio rerio)
REACT:R-BTA-375405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Bos taurus)
REACT:R-DRE-9621179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cinaciguat binds sGC:NO (Danio rerio)
REACT:R-HSA-8876366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL translocates from endosome lumen to lysosome lumen (Homo sapiens)
REACT:R-MMU-6804383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 methylates TP53 (Mus musculus)
REACT:R-PFA-8937169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Plasmodium falciparum)
RHEA:55408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n) + CTP = [phosphate](n+1) + CDP
RHEA:34118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxynorspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine
REACT:R-DME-1250348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by ERBB4 homodimers (Drosophila melanogaster)
REACT:R-DME-2514867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Drosophila melanogaster)
RHEA:56025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
REACT:R-HSA-5629203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH (Homo sapiens)
REACT:R-SCE-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Saccharomyces cerevisiae)
REACT:R-DME-9023861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Drosophila melanogaster)
RHEA:56195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP
GO:0050059	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:lombricine N-phosphotransferase activity
GO:0050059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lombricine kinase activity
REACT:R-BTA-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)
REACT:R-HSA-9708275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A binds PDE4A inhibitors (Homo sapiens)
GO:0102099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD-dependent urate hydroxylase activity
RHEA:64914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate => a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O
REACT:R-DDI-9033514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)
REACT:R-MMU-9013159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GEFs activate CDC42 (Mus musculus)
REACT:R-DDI-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Dictyostelium discoideum)
GO:0015408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Fe3+-transporting ATPase activity
GO:0015408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type Fe3+ transporter
GO:0015408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type ferric iron transporter activity
GO:0015408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate
GO:0015408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferric-transporting ATPase activity
GO:0015408	skos:altLabel	"Fe(3+)-transporting ATPase"
GO:0015408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferric transporting ATPase activity
GO:0015408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric ABC transporter
GO:0015408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type Fe(3+) transporter"
GO:0015408	skos:prefLabel	"ABC-type Fe(3+) transporter"
GO:0015408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled ferric iron transmembrane transporter activity
RHEA:46059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:58358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2
REACT:R-GGA-8865237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD6 methylates RELA in the NFkB complex (Gallus gallus)
REACT:R-BTA-5665999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 translocates from cytosol to the nucleus (Bos taurus)
REACT:R-XTR-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Xenopus tropicalis)
REACT:R-RNO-5672969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF (Rattus norvegicus)
GO:0098615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl selenide methyltransferase activity
GO:0098615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Me2Se is methylated to Me3Se+ by INMT (Homo sapiens)
RHEA:56538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol
REACT:R-HSA-1592238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ALAS1 (Homo sapiens)
REACT:R-CFA-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Canis familiaris)
GO:0070737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-glycine ligase activity, elongating
GO:0070737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein glycylase activity, elongating
GO:0140773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
GO:0140773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD-dependent protein demyristoylase activity
RHEA:45250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(in) => butanoate(out)
RHEA:72694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(out) <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in)
RHEA:53957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-[BtrI ACP] + H(+) => 4-aminobutanoyl-[BtrI ACP] + CO2
REACT:R-GGA-1227775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6/or TRAF2 interacts with IPS-1 (Gallus gallus)
REACT:R-DRE-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Danio rerio)
REACT:R-DRE-372519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcCho is hydrolyzed to Cho and acetate by ACHE (Danio rerio)
RHEA:13995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-3-oxopropanoate + L-glutamate => (S)-3-amino-2-methylpropanoate + 2-oxoglutarate
REACT:R-DRE-8982645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRKs bind ADRB2:Catecholamine (Danio rerio)
REACT:R-RNO-8874202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the cytosol to the nucleus (Rattus norvegicus)
REACT:R-DDI-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Dictyostelium discoideum)
RHEA:35804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 2'-phosphate + H(+)
RHEA:37057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate => 3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate
RHEA:71359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)
GO:0008750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P) transhydrogenase (AB-specific) activity
GO:0008750	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	pyridine nucleotide transhydrogenase activity
GO:0008750	skos:prefLabel	"NAD(P)(+) transhydrogenase (Re/Si-specific)"
GO:0008750	skos:altLabel	"pyridine nucleotide transhydrogenase"
GO:0008750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(P)+ transhydrogenase (AB-specific) activity
GO:0008750	skos:altLabel	"NAD(P)(+) transhydrogenase (AB-specific)"
GO:0008750	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH:NAD+ oxidoreductase (AB-specific)
GO:0008750	skos:altLabel	"transhydrogenase"
GO:0008750	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	transhydrogenase activity
GO:0008750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(P)(+) transhydrogenase (Re/Si-specific)"
GO:0008750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + NADPH = NADH + NADP(+)
REACT:R-MMU-192475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Mus musculus)
REACT:R-HSA-622357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIKE-L interaction with UNC5B (Homo sapiens)
REACT:R-DRE-5423647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)
REACT:R-DDI-8941543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Dictyostelium discoideum)
RHEA:47580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GT2 (d18:1(4E)) + H(+) + UDP
RHEA:33474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol
GO:0004867	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serine protease inhibitor activity
GO:0004867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-type endopeptidase inhibitor activity
GO:0004867	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serine proteinase inhibitor activity
GO:0004867	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serpin activity
RHEA:11788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate
RHEA:35299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoyl-CoA + NADP(+) = 3-oxooctadecanoyl-CoA + H(+) + NADPH
REACT:R-MMU-9750001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Mus musculus)
REACT:R-BTA-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Bos taurus)
RHEA:15949	skos:altLabel	"D-2-hydroxy fatty acid dehydrogenase"
RHEA:15949	skos:prefLabel	"(R)-2-hydroxy-fatty-acid dehydrogenase"
RHEA:15949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-2-hydroxy-fatty-acid dehydrogenase"
RHEA:15949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + H(+) + NADH
REACT:R-SPO-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Schizosaccharomyces pombe)
GO:0030763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isobutyraldoxime O-methyltransferase"
GO:0030763	skos:prefLabel	"isobutyraldoxime O-methyltransferase"
GO:0030763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosylmethionine:aldoxime O-methyltransferase activity
GO:0030763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldoxime methyltransferase activity
GO:0030763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine
GO:0030763	skos:altLabel	"aldoxime methyltransferase"
GO:0030763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity
GO:0030763	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldoxime O-methyltransferase activity
GO:0030763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutyraldoxime O-methyltransferase activity
REACT:R-DRE-1168644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Danio rerio)
RHEA:52740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyphosate + H2O + O2 = aminomethylphosphonate + glyoxylate + H(+) + H2O2
REACT:R-CEL-350769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Activation (Caenorhabditis elegans)
RHEA:47610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA => 3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA
RHEA:66508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0050491	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulcatol:NAD+ oxidoreductase activity
GO:0050491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulcatone reductase activity
REACT:R-BTA-9663492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL dissociates from GSTA1, FABP1 (Bos taurus)
REACT:R-BTA-5693153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1K dephosphorylates p-BCKDH (Bos taurus)
RHEA:59741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + S-octadecanoyl-L-cysteinyl-[protein]
REACT:R-MMU-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Mus musculus)
RHEA:49483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-1-piperideine-6-carboxylate + NADP(+) <=> H(+) + L-2-aminoadipate + NADPH
REACT:R-DME-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Drosophila melanogaster)
RHEA:66355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) <=> (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH
RHEA:71750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + L-2-aminoadipate(in) <=> 2-oxoglutarate(in) + L-2-aminoadipate(out)
REACT:R-HSA-389956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-tubulin:GTP + Cofactor A ->  Beta-tubulin:GTP: Cofactor A (Homo sapiens)
REACT:R-MMU-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Mus musculus)
REACT:R-MMU-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Mus musculus)
RHEA:41331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate
REACT:R-SSC-9709883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB scavenges O2.- (Sus scrofa)
RHEA:46273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-8850831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates KLK8 (Canis familiaris)
REACT:R-SSC-9750016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Sus scrofa)
REACT:R-XTR-375342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)
REACT:R-CFA-9681763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1 binds IL1R1 inhibitors (Canis familiaris)
RHEA:30631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronosyltransferase"
RHEA:30631	skos:altLabel	"D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase"
RHEA:30631	skos:prefLabel	"D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronosyltransferase"
RHEA:30631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate = beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-RNO-174121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Securin with Cdc20:APC/C complex (Rattus norvegicus)
RHEA:41059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA
RHEA:48291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM3 <=> CMP + ganglioside GD3 + H(+)
REACT:R-RNO-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)
REACT:R-SSC-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Sus scrofa)
REACT:R-SSC-2395879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
REACT:R-GGA-111970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates GRK2 (Gallus gallus)
GO:0010385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded methylated DNA binding
REACT:R-DDI-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Dictyostelium discoideum)
REACT:R-RNO-8933446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Rattus norvegicus)
REACT:R-HSA-9622981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPY gene expression is stimulated by FOXO1 (Homo sapiens)
REACT:R-RNO-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Rattus norvegicus)
REACT:R-DRE-5610766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Danio rerio)
GO:0015180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine transmembrane transporter activity
GO:0015180	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-alanine transporter activity
RHEA:65031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-pinoresinol + H2O + 2 oxidized [azurin] <=> (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]
RHEA:69625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-D-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-D-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:35762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Sus scrofa)
REACT:R-RNO-418845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of caspase-3 (Rattus norvegicus)
REACT:R-RNO-199112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRTAM binds to NECL2 (Rattus norvegicus)
RHEA:37012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
EC:1.1.5.3	skos:prefLabel	"glycerol-3-phosphate dehydrogenase"
EC:1.1.5.3	skos:altLabel	"FAD-dependent glycerol-3-phosphate dehydrogenase"
EC:1.1.5.3	skos:altLabel	"L-glycerophosphate dehydrogenase"
EC:1.1.5.3	skos:altLabel	"glycerol-3-phosphate CoQ reductase"
EC:1.1.5.3	skos:altLabel	"sn-glycerol-3-phosphate dehydrogenase"
EC:1.1.5.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-3-phosphate dehydrogenase"
EC:1.1.5.3	skos:altLabel	"flavin-linked glycerol-3-phosphate dehydrogenase"
EC:1.1.5.3	skos:altLabel	"glycerophosphate dehydrogenase"
RHEA:55048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5Z)-dodecadienoyl-CoA + H2O = (3E,5Z)-dodecadienoate + CoA + H(+)
REACT:R-BTA-6808566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHGA-derived peptide binds the bacterial cell surface (Bos taurus)
RHEA:57552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-1604722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP9 by proteases (Canis familiaris)
REACT:R-BTA-194023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)
REACT:R-SPO-507869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol into cells (Schizosaccharomyces pombe)
GO:0050586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity
GO:0050586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = CO + H(+) + N-acetylanthranilate
GO:0050586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity
GO:0050586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)
GO:0050586	skos:altLabel	"(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase"
GO:0050586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase"
GO:0050586	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity
GO:0050586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity
GO:0050586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity
GO:0050586	skos:prefLabel	"3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase"
RHEA:64309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-aminobutanoate + pyruvate => acetoacetate + L-alanine
REACT:R-DRE-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Danio rerio)
REACT:R-MMU-5693551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BRCA1-A complex at multiple sites by ATM (Mus musculus)
GO:0033975	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-haloalkanoid acid halidohydrolase activity
GO:0033975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-haloacid dehalogenase activity
GO:0033975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-2-haloacid dehalogenase activity
GO:0033975	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-haloalkanoic acid dehalogenase activity
GO:0033975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-haloacid halidohydrolase activity
GO:0033975	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-DEX
REACT:R-SSC-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Sus scrofa)
GO:0097506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deaminated base DNA glycosylase activity
GO:0097506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA glycosylase activity acting on deaminated bases
GO:0097506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deaminated base DNA N-glycosylase activity
RHEA:42720	skos:prefLabel	"23S rRNA (uridine(2552)-2'-O)-methyltransferase"
RHEA:42720	skos:altLabel	"FTSJ"
RHEA:42720	skos:altLabel	"Um2552 methyltransferase"
RHEA:42720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (uridine(2552)-2'-O)-methyltransferase"
RHEA:42720	skos:altLabel	"Um(2552) 23S ribosomal RNA methyltransferase"
RHEA:42720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:38912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenacoside B + H2O => 26-desgluco-avenacoside B + D-glucose
RHEA:52991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[deoxyhypusine synthase]-L-lysine + dehydrospermidine <=> [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine
RHEA:20567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S,4R)-endo-fenchol + diphosphate => (2E)-geranyl diphosphate + H2O
RHEA:58175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate <=> beta-pinacene + diphosphate
RHEA:11047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a haloacetate + H2O <=> a halide anion + glycolate + H(+)
RHEA:61527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate
REACT:R-DDI-9638075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from DS (Dictyostelium discoideum)
RHEA:31788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tuberculosinyl diphosphate => (13R)-edaxadiene + diphosphate
REACT:R-HSA-5218640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates p-Y397-PTK2 (Homo sapiens)
RHEA:40706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate
REACT:R-MMU-389821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + O2 => glyoxylate + H2O2 + NH4+ (Mus musculus)
REACT:R-GGA-5675417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEBP1 binds activated RAF1 (Gallus gallus)
RHEA:13701	skos:altLabel	"Homoserine O-trans-acetylase"
RHEA:13701	skos:prefLabel	"homoserine O-acetyltransferase"
RHEA:13701	skos:altLabel	"homoserine transacetylase"
RHEA:13701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine
RHEA:13701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homoserine O-acetyltransferase"
RHEA:52690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + H(+) + NADH => 3-phenyllactate + NAD(+)
REACT:R-SSC-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Sus scrofa)
REACT:R-PFA-110215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by UNG glycosylase (Plasmodium falciparum)
REACT:R-SSC-976991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor ligands bind the prolactin receptor (Sus scrofa)
REACT:R-BTA-1474266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibrils (Bos taurus)
REACT:R-DME-210404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Drosophila melanogaster)
RHEA:16194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)
REACT:R-HSA-9703008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tamatinib-resistant FLT3 mutants don't bind tamatinib (Homo sapiens)
REACT:R-RNO-3371518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1 binds to HSF1 (Rattus norvegicus)
REACT:R-BTA-9696275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND2 binds GTP (Bos taurus)
RHEA:68600	skos:altLabel	"(S)-DHPS dehydratase"
RHEA:68600	skos:prefLabel	"(2S)-3-sulfopropanediol dehydratase"
RHEA:68600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2S)-3-sulfopropanediol dehydratase"
RHEA:68600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfopropanediol = 3-oxopropane-1-sulfonate + H2O
REACT:R-DRE-264871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin B1 (Danio rerio)
REACT:R-BTA-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Bos taurus)
RHEA:30880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + prop-2-ynal => 2 H(+) + NADH + propynoate
RHEA:25295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH
GO:0140900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride:bicarbonate antiporter activity
GO:0140900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bicarbonate:chloride antiporter activity
RHEA:12790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alditol + NADP(+) => an aldose + H(+) + NADPH
RHEA:20983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 bilirubin IXalpha + O2 <=> 2 biliverdin IXalpha + 2 H2O
REACT:R-GGA-9650473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 is secreted (Gallus gallus)
REACT:R-MMU-77587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Replication Dependent Histone mRNA with the NPC (Mus musculus)
REACT:R-DME-391933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP3 receptor can bind PGE2 (Drosophila melanogaster)
RHEA:65149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phloretin + UDP-alpha-D-glucose => H(+) + trilobatin + UDP
RHEA:69277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-N-(sulfonatooxy)prop-2-enimidothioate => but-3-enenitrile + sulfate + sulfur
RHEA:22566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-[ACP] + H(+) + NADPH => a 2,3-saturated acyl-[ACP] + NADP(+)
RHEA:69783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminophenyl)succinate + succinyl-CoA = 2-(2-aminophenyl)succinyl-CoA + succinate
REACT:R-HSA-9624611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3,(FOXO4) bind FBXO32 gene promoter (Homo sapiens)
REACT:R-HSA-8935766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-378 binds RUNX1 mRNA (Homo sapiens)
RHEA:59859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium <=> methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine
GO:0018169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribosomal S6-glutamic acid ligase activity
REACT:R-MMU-1433415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 (Mus musculus)
REACT:R-BTA-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Bos taurus)
RHEA:41764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) = CMP + ganglioside GT3 (d18:1(4E)) + H(+)
GO:0036130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 endoperoxidase reductase activity
GO:0036130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 9-,11-endoperoxide reductase
GO:0036130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 9,11-endoperoxidase
GO:0036130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Homo sapiens)
RHEA:63051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pravastatin lactone <=> H(+) + pravastatin
REACT:R-DRE-2404135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4 binds atROL (Danio rerio)
RHEA:32817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hg(2+)(out) => Hg(2+)(in)
RHEA:60578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein]
REACT:R-DME-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Drosophila melanogaster)
RHEA:26054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-199425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLPP dephosphorylates S473 in AKT (Homo sapiens)
REACT:R-BTA-350604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Agmatine + H2O <=> putrescine + urea (Bos taurus)
REACT:R-SSC-6804266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TTC5 (Sus scrofa)
REACT:R-XTR-9727188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B binds PPIs (Xenopus tropicalis)
GO:0047887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesyl-diphosphate kinase activity
GO:0047887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesyl diphosphate kinase activity
GO:0047887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:farnesyl-diphosphate phosphotransferase activity
GO:0047887	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesyl pyrophosphate kinase activity
REACT:R-HSA-3221843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSR1 (SCARA1) binds collagen (Homo sapiens)
RHEA:27676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dATP => ATP + dADP
RHEA:47793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:35942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brevianamide F + dimethylallyl diphosphate <=> diphosphate + tryprostatin B
REACT:R-GGA-2132047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spontaneous hydrolysis of an internal thioester bond in complement factor C3 (Gallus gallus)
REACT:R-CEL-71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Caenorhabditis elegans)
REACT:R-MMU-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Mus musculus)
RHEA:30848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + glutaryl-CoA + 2 H(+) => (2E)-butenoyl-CoA + CO2 + FADH2
REACT:R-CFA-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Canis familiaris)
RHEA:49334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:67182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate => ATP + glycine + L-glutamyl-[protein]
REACT:R-RNO-5674366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RD binds p-2S MAP2Ks and MAPKs (Rattus norvegicus)
REACT:R-DRE-265645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Influx through Voltage-gated Calcium Channels (Danio rerio)
REACT:R-DDI-1363303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)
REACT:R-SSC-5672011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK:AMP binds the ULK complex (Sus scrofa)
REACT:R-SSC-4420128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates SHB (Sus scrofa)
REACT:R-XTR-9706390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds interacting proteins at trans-Golgi network (Xenopus tropicalis)
RHEA:54809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)
REACT:R-DRE-163825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)
REACT:R-SSC-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)
RHEA:24419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4'-dihydroxyacetophenone + O2 <=> 4-hydroxybenzoate + formate + 2 H(+)
REACT:R-XTR-8865637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFSD2A transports LPC from extracellular region to plasma membrane (Xenopus tropicalis)
REACT:R-BTA-8944454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 phosphorylates MAF1 (Bos taurus)
REACT:R-XTR-448661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)
RHEA:68851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> diphosphate + gamma-cadinene
RHEA:37258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-asparagine + H2O <=> 2-oxosuccinamate + AH2 + NH4(+)
REACT:R-BTA-9706393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds ATP (Bos taurus)
REACT:R-HSA-9694605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement (Homo sapiens)
REACT:R-BTA-3228469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K5 phosphorylates MKK3 and MKK6 (Bos taurus)
REACT:R-CEL-9734070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET recombinant therapeutic antibodies bind MET (Caenorhabditis elegans)
RHEA:45058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + nogalonate => deoxynogalonate + O2
RHEA:57516	skos:altLabel	"CYP71Z16"
RHEA:57516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] = 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57516	skos:prefLabel	"dolabradiene monooxygenase"
RHEA:57516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolabradiene monooxygenase"
REACT:R-HSA-5621352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC6A binds alpha-mannan in fungal cell walls (Homo sapiens)
REACT:R-CEL-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Caenorhabditis elegans)
RHEA:51541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Caenorhabditis elegans)
RHEA:41730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:23470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+) => 2-aminobenzenesulfonate + 2 H(+) + NADH + O2
GO:0031761	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fMet-Leu-Phe receptor ligand
GO:0031761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fMet-Leu-Phe receptor binding
GO:0031761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formyl peptide receptor binding
REACT:R-GGA-3640858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tankyrase ADP-ribosylates AXIN (Gallus gallus)
REACT:R-CEL-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Caenorhabditis elegans)
REACT:R-SPO-9693282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF GAPs stimulate RHOF GTPase activity (Schizosaccharomyces pombe)
REACT:R-CFA-975311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Canis familiaris)
RHEA:48739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-936952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Gallus gallus)
REACT:R-SSC-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Sus scrofa)
RHEA:53740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O = [Rab1 protein]-L-tyrosine + AMP + H(+)
REACT:R-HSA-209973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is diiodinated (Homo sapiens)
REACT:R-GGA-9629492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves spiroiminodihydantoin (Gallus gallus)
REACT:R-BTA-194718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Bos taurus)
REACT:R-HSA-159728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-prothrombin to prothrombin (Homo sapiens)
REACT:R-MMU-5682992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A,B bind H4K20Me2 (Mus musculus)
RHEA:30352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + pyrrole-2-carboxylate => 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)
RHEA:70452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 => a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate
REACT:R-GGA-1168642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Gallus gallus)
RHEA:37680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA
RHEA:58226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide => L-glutamyl-[protein] + NAD(+)
RHEA:13102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-imidazolone-5-propanoate => H2O + trans-urocanate
REACT:R-DRE-212710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR activates PLC-gamma1 by phosphorylation (Danio rerio)
RHEA:65382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine
REACT:R-RNO-5339535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTPD1 transports C1P from plasma membrane to Golgi membrane (Rattus norvegicus)
RHEA:28687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + ubiquinone-8 = orotate + ubiquinol-8
RHEA:28687	skos:prefLabel	"dihydroorotate dehydrogenase (quinone)"
RHEA:28687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydroorotate dehydrogenase (quinone)"
RHEA:28687	skos:altLabel	"DHOD"
RHEA:28687	skos:altLabel	"DHODH"
RHEA:28687	skos:altLabel	"DHOdehase"
RHEA:27292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + CO2 => A + formate + H(+)
REACT:R-SPO-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Schizosaccharomyces pombe)
GO:0003845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	11beta-hydroxy steroid dehydrogenase
GO:0003845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	corticosteroid 11-reductase
GO:0003845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	11beta-hydroxysteroid dehydrogenase
GO:0003845	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-hydroxysteroid dehydrogenase
GO:0003845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
GO:0003845	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	corticosteroid 11beta-dehydrogenase
REACT:R-RNO-3322005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Rattus norvegicus)
REACT:R-XTR-183122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor D cleaves C3b-bound Factor B (Xenopus tropicalis)
REACT:R-HSA-5687284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMBT1 binds SFTPD 12mer, SFTPAs (Homo sapiens)
REACT:R-CFA-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)
EC:3.4.24.24	skos:altLabel	"matrix metalloproteinase 2"
EC:3.4.24.24	skos:prefLabel	"gelatinase A"
EC:3.4.24.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gelatinase A"
EC:3.4.24.24	skos:altLabel	"type IV collagenase"
EC:3.4.24.24	skos:altLabel	"72-kDa gelatinase"
REACT:R-HSA-9021935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SST gene expression is stimulated by MECP2 and CREB1 (Homo sapiens)
RHEA:55205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine => 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribodipyrimidine photo-lyase activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dipyrimidine photolyase (photosensitive)
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	photoreactivating enzyme activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPD photolyase activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phr A photolyase activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA cyclobutane dipyrimidine photolyase activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-photoreactivating enzyme
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribocyclobutadipyrimidine pyrimidine-lyase activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PhrB photolyase activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleate pyrimidine dimer lyase (photosensitive)
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic cyclobutane dipyrimidine photolyase activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxyribonucleic photolyase activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribodipyrimidine photolyase activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	photolyase activity
GO:0003904	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PRE
REACT:R-RNO-430311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rsu-1 interacts with Pinch1 (Rattus norvegicus)
RHEA:21086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dermatan 4'-sulfate => chondroitin 4'-sulfate
REACT:R-BTA-5660980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S276-RELA binds RELB (Bos taurus)
RHEA:32385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH => (1S,2S,4R)-limonene-1,2-diol + NAD(+)
REACT:R-BTA-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Bos taurus)
REACT:R-DME-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Drosophila melanogaster)
RHEA:12029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-5-carboxymethylhydantoin => H(+) + N-carbamoyl-L-aspartate
RHEA:70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sitosterol(out) => sitosterol(in)
GO:0047708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinidase activity
GO:0047708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biotin-amide amidohydrolase activity
GO:0047708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amidohydrolase biotinidase activity
REACT:R-CFA-170843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 phosphorylates TGFBR1 (Canis familiaris)
GO:0102538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity
RHEA:58554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(16R)-deshydroxymethyl-stemmadenine + formate => 15alpha-stemmadenine intermediate II + H2O
REACT:R-BTA-71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Bos taurus)
RHEA:41956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-CMP + H2O = cytidine 2'-phosphate + H(+)
REACT:R-CEL-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Caenorhabditis elegans)
REACT:R-SSC-70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Sus scrofa)
RHEA:32400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R,4S)-neodihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH
RHEA:46781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-389974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)
RHEA:59913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-enal + H2O + NADP(+) => (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH
REACT:R-CFA-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Canis familiaris)
GO:0043799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine oxidase activity
GO:0043799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine:oxygen oxidoreductase (deaminating)
REACT:R-XTR-933531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-IRF7:p-IRF7 to nucleus (Xenopus tropicalis)
RHEA:65496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH = 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)
RHEA:53190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O
REACT:R-MMU-2065355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)
REACT:R-CFA-1497784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)
RHEA:16542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-violaxanthin + O2 => (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin
RHEA:47542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADPH
GO:0008816	skos:prefLabel	"citryl-CoA lyase"
GO:0008816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-citryl-CoA oxaloacetate-lyase activity
GO:0008816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citryl-CoA lyase"
GO:0008816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citryl-CoA = acetyl-CoA + oxaloacetate
GO:0008816	skos:altLabel	"(3S)-citryl-CoA oxaloacetate-lyase"
GO:0008816	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)
GO:0008816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citryl-CoA lyase activity
REACT:R-SSC-9757706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Sus scrofa)
RHEA:24810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O
REACT:R-RNO-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Rattus norvegicus)
RHEA:10376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"P-type Cu(2+) transporter"
RHEA:10376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Cu(2+)(in) + H2O = ADP + Cu(2+)(out) + H(+) + phosphate
RHEA:10376	skos:altLabel	"Cu(2+)-exporting ATPase"
RHEA:10376	skos:prefLabel	"P-type Cu(2+) transporter"
REACT:R-HSA-8866279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Epsin family proteins bind ubiquitinated cargo (Homo sapiens)
REACT:R-HSA-2424246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tenascins C, R, (X, N) bind lecticans (Homo sapiens)
REACT:R-HSA-2022052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Homo sapiens)
RHEA:19604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + orcinol <=> 2,3,5-trihydroxytoluene + H2O + NAD(+)
REACT:R-MMU-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Mus musculus)
RHEA:34713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine + a fatty acid => H2O + N-acyl-15-methylhexadecasphing-4-enine
REACT:R-BTA-174451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of DNA2 endonuclease to the C strand (Bos taurus)
REACT:R-BTA-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Bos taurus)
REACT:R-DME-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Drosophila melanogaster)
REACT:R-BTA-399930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PAK by Rac1 (Bos taurus)
REACT:R-SPO-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)
REACT:R-GGA-445071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reinsertion of L1 into the plasma membrane (Gallus gallus)
RHEA:69798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartyl-tRNA(Asp) + H2O <=> D-aspartate + H(+) + tRNA(Asp)
RHEA:49293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]
REACT:R-CFA-372542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of dopamine into synaptic veiscles (Canis familiaris)
REACT:R-SSC-1614524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Sus scrofa)
REACT:R-RNO-8951676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TEADs and YAP1 (Rattus norvegicus)
REACT:R-XTR-8987070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)
REACT:R-BTA-391941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLT receptors can bind LTB4 (Bos taurus)
GO:0047274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactinol:sucrose 6-galactosyl transferase activity
GO:0047274	skos:altLabel	"raffinose synthase"
GO:0047274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactinol--sucrose galactosyltransferase"
GO:0047274	skos:prefLabel	"galactinol--sucrose galactosyltransferase"
GO:0047274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	raffinose synthase activity
GO:0047274	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity
GO:0047274	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity
GO:0047274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactinol-sucrose galactosyltransferase activity
GO:0047274	skos:altLabel	"1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase"
GO:0047274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose = myo-inositol + raffinose
GO:0047274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosyltransferase, galactinol-sucrose
REACT:R-DRE-201423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKI complexes with the Smad complex, suppressing BMP2 signalling (Danio rerio)
REACT:R-XTR-917807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Xenopus tropicalis)
RHEA:31716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:24209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-mannitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH
GO:0004496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonic acid kinase activity
GO:0004496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:(R)-mevalonate 5-phosphotransferase activity
GO:0004496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonate 5-phosphotransferase activity
GO:0004496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MVA kinase activity
GO:0004496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonate phosphokinase activity
GO:0004496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonic kinase activity
GO:0004496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mevalonate kinase (phosphorylating)
GO:0004496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mevalonate kinase activity
GO:0004496	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:mevalonate 5-phosphotransferase activity
RHEA:68623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + H(+) + NADPH <=> 20beta-dihydrocortisone + NADP(+)
REACT:R-HSA-977602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)
RHEA:31803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose = 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP
RHEA:31803	skos:altLabel	"UDP-6-deoxy-AltdiNAc hydrolase"
RHEA:31803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase"
RHEA:31803	skos:prefLabel	"UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase"
RHEA:32353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine => 3 S-adenosyl-L-methionine + tricetin
RHEA:54719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:59473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP + H2O => Gp(2'-5')Ap(3') + H(+)
REACT:R-MMU-69195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Mus musculus)
RHEA:52634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP
REACT:R-SPO-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)
RHEA:53857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + ursocholate => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH
RHEA:30531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotinate sulfoxide + H(+) + NADH = biotin + H2O + NAD(+)
REACT:R-MMU-4655431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOyation of DNMT1 with SUMO1 (Mus musculus)
REACT:R-HSA-448951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38 alpha/beta MAPK (Homo sapiens)
RHEA:62721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 NADPH + 3 O2 + probetaenone I => betaenone B + 3 H2O + 3 NADP(+)
REACT:R-MMU-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Mus musculus)
RHEA:38220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
GO:0005026	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transforming growth factor beta ligand binding to type II receptor
GO:0005026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II transforming growth factor beta receptor activity
GO:0005026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II TGF-beta receptor activity
GO:0005026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transforming growth factor beta receptor activity, type II
GO:0005026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II TGFbeta receptor activity
GO:0005026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 phosphorylates TGFBR1 (Homo sapiens)
RHEA:56334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenosine + H2O
REACT:R-HSA-193424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
RHEA:72925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III => O2 + proatranorin II + reduced [NADPH--hemoprotein reductase]
RHEA:72981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asterriquinone C1 + diphosphate => didemethylasterriquinone D + dimethylallyl diphosphate
RHEA:69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + L-glutamyl-[beta-tubulin] <=> ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate
REACT:R-HSA-176646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Homo sapiens)
REACT:R-SPO-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Schizosaccharomyces pombe)
REACT:R-RNO-110141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Rattus norvegicus)
RHEA:66431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose(out) + H(+)(out) <=> D-arabinose(in) + H(+)(in)
REACT:R-RNO-390256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Rattus norvegicus)
RHEA:41959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-CMP + H2O <=> cytidine 2'-phosphate + H(+)
REACT:R-DRE-2396079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds Plasminogen activator inhibitor- 1 (Danio rerio)
RHEA:72050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline <=> AH2 + fusahexin + 6 H2O
RHEA:71042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) + L-phenylalanine(out) <=> L-methionine(out) + L-phenylalanine(in)
REACT:R-GGA-4719447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO1 (Gallus gallus)
REACT:R-DRE-73806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIR + CO2 => CAIR (Danio rerio)
REACT:R-DDI-1482745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Dictyostelium discoideum)
REACT:R-RNO-870437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X (FAM) deubiquitinates SMAD4 (Rattus norvegicus)
REACT:R-RNO-445752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Rattus norvegicus)
REACT:R-GGA-426520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endonucleolytic RISC hydrolyzes target RNAs (Gallus gallus)
RHEA:16901	skos:altLabel	"DABA acetyltransferase"
RHEA:16901	skos:altLabel	"L-2,4-diaminobutyrate acetyltransferase"
RHEA:16901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)
RHEA:16901	skos:altLabel	"DABAcT"
RHEA:16901	skos:altLabel	"L-2,4-diaminobutanoate acetyltransferase"
RHEA:16901	skos:altLabel	"2,4-diaminobutanoate acetyltransferase"
RHEA:16901	skos:altLabel	"diaminobutyric acid acetyltransferase"
RHEA:16901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diaminobutyrate acetyltransferase"
RHEA:16901	skos:altLabel	"DAB acetyltransferase"
RHEA:16901	skos:prefLabel	"diaminobutyrate acetyltransferase"
REACT:R-CFA-8943003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH polyubiquitinates monoubiquitinated PCNA (Canis familiaris)
REACT:R-CEL-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Caenorhabditis elegans)
RHEA:18691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O
REACT:R-RNO-8879117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT2 transfers GlcNAc to Man-DAG1 (Rattus norvegicus)
GO:0102663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity
RHEA:43968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate
RHEA:19405	skos:prefLabel	"citrate CoA-transferase"
RHEA:19405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"citrate CoA-transferase"
RHEA:19405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + citrate = (3S)-citryl-CoA + acetate
REACT:R-MMU-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Mus musculus)
RHEA:42622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylaminoacrylate + CO2 + NH4(+) => (Z)-2-methylureidoacrylate + H(+) + H2O
RHEA:34730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphinganine <=> 15-methylhexadecasphinganine + a carboxylate
RHEA:30198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,9'-di-cis-phytofluene + plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + plastoquinol-9
GO:0031825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 1F receptor binding
GO:0031825	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1F serotonin receptor ligand
GO:0031825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1F serotonin receptor binding
GO:0030783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[cytochrome c]-methionine S-methyltransferase activity
GO:0030783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity
GO:0030783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c-methionine S-methyltransferase activity
REACT:R-SSC-3322422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits SMARCA4 (Sus scrofa)
REACT:R-SSC-444661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCAR2 binds HCAR2 ligands (Sus scrofa)
REACT:R-HSA-429815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation Of Bloc-1 Complex (Homo sapiens)
GO:0034932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-methoxypyrene 6,7-monooxygenase activity
REACT:R-HSA-9670049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defects in F8 A1 domain accelerate dissociation of the A2 domain (Homo sapiens)
RHEA:38132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol => 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
RHEA:43745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cytidine(34) in tRNA(Ile2) + L-lysine => AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)
REACT:R-RNO-199298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CREB1 (Rattus norvegicus)
RHEA:28865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + lactose(out) => H(+)(out) + lactose(in)
RHEA:23129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate
REACT:R-SSC-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Sus scrofa)
RHEA:51962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanenitrile + H2O => (Z)-2-methylpropanal oxime
REACT:R-XTR-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Xenopus tropicalis)
RHEA:29851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N-acetyl-alpha-D-galactosamine = 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP
RHEA:12172	skos:altLabel	"GlcN6P deaminase"
RHEA:12172	skos:prefLabel	"glucosamine-6-phosphate deaminase"
RHEA:12172	skos:altLabel	"phosphoglucosaminisomerase"
RHEA:12172	skos:altLabel	"phosphoglucosamine isomerase"
RHEA:12172	skos:altLabel	"glucosamine phosphate deaminase"
RHEA:12172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosamine-6-phosphate deaminase"
RHEA:12172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
RHEA:12172	skos:altLabel	"glucosamine-6-phosphate isomerase"
REACT:R-CEL-444120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:39211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexacosanoyl-CoA = (2E)-hexacosenoyl-CoA + H2O
REACT:R-GGA-5419271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Gallus gallus)
REACT:R-DRE-159046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Danio rerio)
RHEA:48450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
RHEA:19362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + isopentenyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate
RHEA:24608	skos:prefLabel	"5-dehydro-4-deoxyglucarate dehydratase"
RHEA:24608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-dehydro-4-deoxyglucarate dehydratase"
RHEA:24608	skos:altLabel	"5-keto-4-deoxy-glucarate dehydratase"
RHEA:24608	skos:altLabel	"D-4-deoxy-5-ketoglucarate hydro-lyase"
RHEA:24608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O
REACT:R-CFA-1168636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Canis familiaris)
REACT:R-BTA-4641345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2B with SUMO1 (Bos taurus)
REACT:R-DRE-350319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of vimentin at IDVD (259) (Danio rerio)
REACT:R-XTR-4084980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Xenopus tropicalis)
REACT:R-XTR-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Xenopus tropicalis)
RHEA:38121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol
REACT:R-BTA-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Bos taurus)
REACT:R-CFA-420593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR:PVRL3 trans heterodimer interaction (Canis familiaris)
RHEA:38270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylfumaryl-CoA <=> 3-methylfumaryl-CoA
REACT:R-CFA-174452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha on the C-strand of the telomere (Canis familiaris)
REACT:R-CEL-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Caenorhabditis elegans)
REACT:R-RNO-446391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the PINCH-ILK-parvin complex (Rattus norvegicus)
RHEA:39428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)
RHEA:69472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose = a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]
RHEA:63496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrobenzaldehyde + H(+) + NADPH = 4-nitrobenzyl alcohol + NADP(+)
REACT:R-MMU-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Mus musculus)
REACT:R-CFA-194121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-DDI-9664855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)
REACT:R-HSA-8939323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)
REACT:R-DDI-71682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
RHEA:32517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O
REACT:R-MMU-5624130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylated NPHP3 translocates into the ciliary membrane (Mus musculus)
RHEA:50320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-1482759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Bos taurus)
REACT:R-GGA-8951676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TEADs and YAP1 (Gallus gallus)
REACT:R-XTR-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Xenopus tropicalis)
RHEA:12423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-tagatofuranose 6-phosphate <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)
REACT:R-CEL-9020271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Caenorhabditis elegans)
RHEA:35276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoyl-CoA + NAD(+) => 3-oxooctadecanoyl-CoA + H(+) + NADH
REACT:R-HSA-1604690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MMP9 intermediate form by MMPs (Homo sapiens)
RHEA:14629	skos:prefLabel	"acetylglutamate kinase"
RHEA:14629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylglutamate kinase"
RHEA:14629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate
REACT:R-DRE-3772430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNNBIP1 binds beta-catenin (Danio rerio)
REACT:R-CFA-5621370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Canis familiaris)
RHEA:21467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + thiocyanate <=> carbonyl sulfide + NH4(+)
EC:3.4.22.63	skos:altLabel	"apoptotic protease Mch-4"
EC:3.4.22.63	skos:altLabel	"FLICE2"
EC:3.4.22.63	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caspase-10"
EC:3.4.22.63	skos:altLabel	"ICE-like apoptotic protease 4"
EC:3.4.22.63	skos:prefLabel	"caspase-10"
EC:3.4.22.63	skos:altLabel	"FAS-associated death domain protein interleukin-1beta-converting enzyme 2"
EC:3.4.22.63	skos:altLabel	"Mch4"
EC:3.4.22.63	skos:altLabel	"CASP-10"
RHEA:30901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP => bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose
RHEA:45465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SSC-927830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Sus scrofa)
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lactate cytochrome c oxidoreductase activity
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lactate ferricytochrome c oxidoreductase activity
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactate dehydrogenase (cytochrome)
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, lactate (cytochrome)
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome b2 (flavin-free derivative of flavocytochrome b2)
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-lactate:ferricytochrome-c 2-oxidoreductase activity
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L(+)-lactate:cytochrome c oxidoreductase activity
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lactate cytochrome c reductase activity
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lactic acid dehydrogenase activity
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavocytochrome b2
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lactate dehydrogenase (cytochrome) activity
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lactic cytochrome c reductase activity
GO:0004460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome b2
REACT:R-DRE-5661123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate Me2K5-histone H3 (Danio rerio)
REACT:R-SSC-74885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCYs converts GTP to cGMP (Sus scrofa)
REACT:R-MMU-2162253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Mus musculus)
RHEA:41233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-RNO-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-DDI-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Dictyostelium discoideum)
REACT:R-BTA-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Bos taurus)
RHEA:22285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-carbamoylputrescine => CO2 + NH4(+) + putrescine
REACT:R-MMU-8931858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Mus musculus)
REACT:R-CFA-8876312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Canis familiaris)
RHEA:43695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] <=> AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]
REACT:R-CFA-420586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Necl-2 trans heterodimer interaction (Canis familiaris)
RHEA:13968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L,L-cystathionine <=> L-homocysteine + NH4(+) + pyruvate
REACT:R-BTA-420131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PACAP receptor binds PACAP (Bos taurus)
REACT:R-DRE-912685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBP43 binds IFNAR2 and prevents JAK1 interaction (Danio rerio)
REACT:R-HSA-1989753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PEX11A (Homo sapiens)
REACT:R-MMU-2129385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFAP2, MFAP5 bind microfibrils (Mus musculus)
RHEA:18121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate
RHEA:18121	skos:altLabel	"S-alkyl-L-cysteine sulfoxide lyase"
RHEA:18121	skos:altLabel	"S-alkylcysteinase"
RHEA:18121	skos:prefLabel	"cysteine-S-conjugate beta-lyase"
RHEA:18121	skos:altLabel	"S-alkylcysteine lyase"
RHEA:18121	skos:altLabel	"alkyl cysteine lyase"
RHEA:18121	skos:altLabel	"S-alkyl-L-cysteine lyase"
RHEA:18121	skos:altLabel	"L-cysteine-S-conjugate thiol-lyase (deaminating)"
RHEA:18121	skos:altLabel	"cystathionine beta-lyase"
RHEA:18121	skos:altLabel	"alkylcysteine lyase"
RHEA:18121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteine-S-conjugate beta-lyase"
RHEA:18121	skos:altLabel	"cystine lyase"
RHEA:53079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:28426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allulose 6-phosphate = keto-D-fructose 6-phosphate
REACT:R-GGA-977237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex (Gallus gallus)
RHEA:72552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(out) + urate(in) => glutarate(in) + urate(out)
REACT:R-SSC-9626816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds p-S345-NCF1 (Sus scrofa)
RHEA:62916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine = an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-RNO-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Rattus norvegicus)
REACT:R-CFA-191116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Canis familiaris)
RHEA:62673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:66246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + IC-asc-C9-AMP => ATP + H(+) + IC-asc-C9
REACT:R-CFA-193703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta is activated (Canis familiaris)
REACT:R-BTA-3159259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAA:MUT binds AdoCbl (Bos taurus)
RHEA:41136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)
RHEA:67738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aceneuramate => N-acetyl-alpha-neuraminate
REACT:R-HSA-2028651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Homo sapiens)
REACT:R-RNO-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Rattus norvegicus)
RHEA:53936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)
RHEA:31962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Xenopus tropicalis)
RHEA:46998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxypseudooxynicotine => 6-hydroxy-N-methylmyosmine + H2O
REACT:R-XTR-2245218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates PHF8 (Xenopus tropicalis)
REACT:R-DRE-373061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR3, 4 and 5 bind CCL5 ligand (Danio rerio)
RHEA:56554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phospho-L-threonyl-[rhodopsin] => ATP + L-threonyl-[rhodopsin]
REACT:R-RNO-8950518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Rattus norvegicus)
REACT:R-DRE-71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Danio rerio)
RHEA:15319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose + an alcohol => a 2-deoxy-alpha-D-glucoside + H2O
RHEA:41992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH
REACT:R-SPO-3371531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation  by pERK1/2 (Schizosaccharomyces pombe)
RHEA:17025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + xylitol = H(+) + L-xylulose + NADPH
RHEA:17025	skos:prefLabel	"L-xylulose reductase"
RHEA:17025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-xylulose reductase"
REACT:R-SSC-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Sus scrofa)
REACT:R-MMU-373705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase cleavage of DCC (Mus musculus)
RHEA:19126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-serine => 3-hydroxypyruvate + glycine
RHEA:35886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-MMU-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Mus musculus)
REACT:R-HSA-437192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PRKCZ (Homo sapiens)
REACT:R-MMU-186834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Mus musculus)
REACT:R-DRE-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Danio rerio)
REACT:R-XTR-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Xenopus tropicalis)
RHEA:50643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)ethylmalate <=> 3-(2-methylsulfanyl)ethylmalate
REACT:R-GGA-168915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Gallus gallus)
RHEA:20662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanyl-D-alanine + H2O => 2 D-alanine
RHEA:39302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)
RHEA:11011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate
REACT:R-HSA-193535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)
GO:0047798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexaglucanase activity
GO:0047798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclomaltodextrinase"
GO:0047798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclodextrinase activity
GO:0047798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclomaltodextrin dextrin-hydrolase (decyclizing)
GO:0047798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclomaltodextrinase activity
GO:0047798	skos:prefLabel	"cyclomaltodextrinase"
GO:0047798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclomaltodextrin + H2O = linear maltodextrin
GO:0047798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cycloheptaglucanase activity
REACT:R-GGA-751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:Gz complex dissociates (Gallus gallus)
REACT:R-GGA-114542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1,RAC2,RHOG activate PI3K (Gallus gallus)
REACT:R-RNO-5218820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src kinases phosphorylate VAV (Rattus norvegicus)
RHEA:55402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaeosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + NH4(+)
GO:0106078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone succinyltransferase activity
REACT:R-HSA-1655443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine (Homo sapiens)
REACT:R-GGA-936802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)
REACT:R-DRE-5654662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)
REACT:R-MMU-873951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1:HSP90 binds inactive NLRP3 (Mus musculus)
GO:0030109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLA-B specific inhibitory MHC class I receptor activity
REACT:R-GGA-9008684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylation (Gallus gallus)
RHEA:48504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-D-manno-heptose 1-phosphate + phosphate
REACT:R-DRE-9691174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the ER membrane (Danio rerio)
RHEA:67764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-CFA-5672012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex phosphorylates PtdIns (Canis familiaris)
REACT:R-SPO-3299680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Schizosaccharomyces pombe)
REACT:R-GGA-6803771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Gallus gallus)
RHEA:45934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA
REACT:R-MMU-8941623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)
RHEA:41061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA
RHEA:60217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate
REACT:R-DDI-8950782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 binds p-STAT3 (Dictyostelium discoideum)
RHEA:14441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + gentamicin C = CoA + H(+) + N(3)-acetylgentamycin C
RHEA:14441	skos:altLabel	"gentamycin acetyltransferase I"
RHEA:14441	skos:prefLabel	"gentamicin 3-N-acetyltransferase"
RHEA:14441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gentamicin 3-N-acetyltransferase"
RHEA:14441	skos:altLabel	"aminoglycoside acetyltransferase AAC(3)-1"
GO:0120147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formylglycine-generating oxidase activity
REACT:R-HSA-5684887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of CHEK1 at resected DNA DSBs (Homo sapiens)
REACT:R-XTR-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Xenopus tropicalis)
RHEA:28817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate(out) + H(+)(in) => 4-hydroxybenzoate(in) + H(+)(out)
RHEA:19049	skos:prefLabel	"hydroxylysine kinase"
RHEA:19049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)
RHEA:19049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxylysine kinase"
RHEA:41208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
REACT:R-DME-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Drosophila melanogaster)
RHEA:66021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O
RHEA:33784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1(F)-beta-D-fructosylsucrose + sucrose => 1,6-kestotetraose + beta-D-glucose
GO:0005231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Homo sapiens)
GO:0005231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	excitatory extracellular ligand-gated ion channel activity
REACT:R-DME-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)
REACT:R-XTR-420274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIP receptor binds gastric inhibitory peptide (Xenopus tropicalis)
RHEA:17241	skos:prefLabel	"alpha-amino-acid esterase"
RHEA:17241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-amino-acid esterase"
RHEA:17241	skos:altLabel	"alpha-amino-acid ester hydrolase"
RHEA:17241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-amino acid ester + H2O = an alcohol + an alpha-amino acid + H(+)
RHEA:24338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + an acyl-CoA + diphosphate => a carboxylate + ATP + CoA
REACT:R-RNO-8951498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Rattus norvegicus)
REACT:R-DDI-73810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAM + ATP => AIR + ADP + Pi (Dictyostelium discoideum)
REACT:R-DRE-5687094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 phosphorylate MAPKAPK5 (Danio rerio)
REACT:R-GGA-5653770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)
RHEA:62709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)butanoate + UDP-alpha-D-glucose => 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP
REACT:R-XTR-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
GO:0000703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endonuclease III
GO:0000703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
GO:0000703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized pyrimidine base lesion DNA N-glycosylase activity
GO:0000703	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA glycosylase/beta-lyase
GO:0000703	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DNA glycosylase/AP-lyase
GO:0000703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endodeoxyribonuclease III
GO:0000703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
GO:0000703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endonuclease VIII activity
GO:0000703	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	bifunctional DNA glycosylase
REACT:R-HSA-420661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions (Homo sapiens)
REACT:R-DME-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Drosophila melanogaster)
RHEA:17209	skos:prefLabel	"enamidase"
RHEA:17209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"enamidase"
RHEA:17209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4(+)
REACT:R-XTR-6785648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEMO1 binds RHOA:GTP:DIAPH1 (Xenopus tropicalis)
REACT:R-MMU-110350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of TDG glycosylase by APEX1 at the AP site (Mus musculus)
RHEA:37838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aklavinone + H(+) + NADPH + O2 <=> epsilon-rhodomycinone + H2O + NADP(+)
REACT:R-CEL-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Caenorhabditis elegans)
REACT:R-DRE-2172123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SIGLEC14/15/16 and DAP12 (Danio rerio)
REACT:R-HSA-8964498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DREAM complex binds the CDC6 gene promoter (Homo sapiens)
RHEA:19321	skos:prefLabel	"dimethylaniline-N-oxide aldolase"
RHEA:19321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylaniline-N-oxide aldolase"
RHEA:19321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylaniline N-oxide = formaldehyde + N-methylaniline
RHEA:19321	skos:altLabel	"N,N-dimethylaniline-N-oxide formaldehyde-lyase"
REACT:R-DDI-77090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of GMP-cap by RNA Methyltransferase (Dictyostelium discoideum)
RHEA:33366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannitol 1-phosphate(in) + L-histidyl-[protein]
RHEA:51026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+) => H(+) + NADH + O2 + toluene-4-sulfonate
RHEA:54812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-7-isojasmonate + ATP + L-isoleucine = AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate
REACT:R-DME-2730889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)
REACT:R-DRE-9023626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)
RHEA:22286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NH4(+) + putrescine => 2 H(+) + H2O + N-carbamoylputrescine
REACT:R-XTR-9649963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASIC3 channel blockers bind ASIC3 trimer (Xenopus tropicalis)
RHEA:59777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + O2 => D-arabinose + H2O2
REACT:R-DRE-375160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 binds to ATP (Danio rerio)
RHEA:44464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine
RHEA:63813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(8)-citryl-spermidine + spermidine => AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)
REACT:R-HSA-8863471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR is bound by DAB2 and ARH (Homo sapiens)
REACT:R-SSC-71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Sus scrofa)
REACT:R-SSC-1606807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Sus scrofa)
RHEA:13907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-MMU-2066781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Mus musculus)
RHEA:65262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypentacecilide A => verruculide C epoxide
RHEA:33379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyeicosasphinganine 1-phosphate + H2O = (4R)-hydroxyeicosasphinganine + phosphate
REACT:R-XTR-1676174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Xenopus tropicalis)
RHEA:24402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + UDP => ATP + UMP
RHEA:68880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + NADPH + salicylate = AMP + diphosphate + NADP(+) + salicylaldehyde
REACT:R-HSA-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Homo sapiens)
REACT:R-XTR-9678935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Xenopus tropicalis)
REACT:R-BTA-198563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO1 dioxygenates L-Trp to NFK (Bos taurus)
RHEA:66617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg(2+)(in) + 2 Na(+)(out) => Mg(2+)(out) + 2 Na(+)(in)
GO:0033976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DL-2-haloacid halidohydrolase (inversion of configuration) activity
GO:0033976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DL-2-haloacid dehalogenase (inversion of configuration) activity
GO:0033976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-haloacid dehalogenase (configuration-inverting) activity
GO:0033976	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-haloalkanoic acid dehalogenase activity
GO:0033976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DL-DEXi
GO:0033976	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	DL-2-haloacid dehalogenase activity
GO:0033976	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-haloalkanoid acid halidohydrolase activity
REACT:R-SSC-2672334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNN channels transport extracellular Na+ to cytosol (Sus scrofa)
RHEA:42204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + NAD(+) = 11-dehydrocorticosterone + H(+) + NADH
REACT:R-DME-1482546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)
REACT:R-BTA-114392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Bos taurus)
RHEA:17753	skos:altLabel	"S-ribosylhomocysteinase"
RHEA:17753	skos:prefLabel	"S-ribosylhomocysteine lyase"
RHEA:17753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-ribosylhomocysteine lyase"
RHEA:17753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine
REACT:R-MMU-9678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 binds S1PR1 agonists (Mus musculus)
RHEA:70779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + NADP(+) = 6-dehydro-D-glucose + H(+) + NADPH
RHEA:10697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + holo-[mycocerosate synthase] => AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]
RHEA:34920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine(in) => thiamine(out)
RHEA:22995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + CoA + NAD(+) <=> acetyl-CoA + CO2 + NADH
RHEA:55023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O <=> 5,6-diaminouracil + D-ribose 5-phosphate
REACT:R-CEL-5624492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK phosphorylates p21 RAF1 on S338 (Caenorhabditis elegans)
REACT:R-HSA-5655955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer (Homo sapiens)
REACT:R-XTR-193060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)
REACT:R-DRE-5635845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind CDC73 (Danio rerio)
GO:0035560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pheophorbidase activity
GO:0035560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phedase activity
GO:0035560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPD activity
GO:0035560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pheophoridase activity
RHEA:22025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + trimethylamine => 2 H(+) + NADH + trimethylamine N-oxide
REACT:R-BTA-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Bos taurus)
RHEA:52475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:69075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + serotonin <=> (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
REACT:R-MMU-2046285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The keratan chain can be capped by N-acetylneuraminic acid (Mus musculus)
REACT:R-MMU-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Mus musculus)
REACT:R-RNO-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Rattus norvegicus)
GO:0102963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-corytuberine synthase activity
RHEA:15568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-L-amino acid + H2O <=> a carboxylate + an L-alpha-amino acid
RHEA:52616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)
RHEA:46462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-5669097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA trimer binds TNFRSF1A,1B,14 (Danio rerio)
RHEA:21289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + sn-glycerol 3-phosphate => D-glucose 6-phosphate + glycerol
REACT:R-HSA-8961665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
REACT:R-HSA-77069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)
REACT:R-RNO-2076220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
REACT:R-SSC-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Sus scrofa)
REACT:R-CFA-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Canis familiaris)
REACT:R-MMU-909552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 at Ser727 (Mus musculus)
REACT:R-CFA-73812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)
REACT:R-DRE-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)
REACT:R-BTA-139842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Syk tyrosine kinase (Bos taurus)
RHEA:67892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine = 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)
GO:0061811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-ribosyl cyclase activity
GO:0102956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity
REACT:R-RNO-1169404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ISG15 from E1 to E2 (UBCH8) (Rattus norvegicus)
REACT:R-GGA-349657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)
RHEA:41751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)
RHEA:64393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dipeptide(out) + H(+)(out) => a dipeptide(in) + H(+)(in)
GO:0050536	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-N-acetyl-1-phenylethylamine amidohydrolase activity
GO:0050536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-acetyl-1-phenylethylamine hydrolase activity
GO:0050536	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-N-acetylphenylethylamine:H2O hydrolase activity
REACT:R-DME-432110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Drosophila melanogaster)
REACT:R-DRE-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Danio rerio)
REACT:R-BTA-2161948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Bos taurus)
REACT:R-MMU-6811412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer to the Golgi (Mus musculus)
REACT:R-SSC-9727188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B binds PPIs (Sus scrofa)
RHEA:55259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:19231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic carboxylate + ATP + H(+) + NADPH => AMP + an aromatic aldehyde + diphosphate + NADP(+)
RHEA:22540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-dehydroadenosine + H2O + O2 = 9-riburonosyladenine + H(+) + H2O2
RHEA:19649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)
RHEA:19649	skos:prefLabel	"aspartate--tRNA ligase"
RHEA:19649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate--tRNA ligase"
RHEA:19649	skos:altLabel	"aspartyl-tRNA synthetase"
RHEA:19649	skos:altLabel	"aspartic acid translase"
RHEA:19978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + L-tyrosine methyl ester => adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate
REACT:R-BTA-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Bos taurus)
REACT:R-DRE-9690494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB translocates to the endosome membrane (Danio rerio)
REACT:R-RNO-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Rattus norvegicus)
REACT:R-DRE-77331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Danio rerio)
RHEA:17374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin => all-trans-capsanthin
RHEA:27346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + O2 => 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)
RHEA:23779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate <=> 4-phospho-L-aspartate + ADP
REACT:R-RNO-8849857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLK5 cleaves and activates CELA2 (Rattus norvegicus)
REACT:R-DME-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)
RHEA:58905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH => C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)
REACT:R-RNO-4090288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate MBD1 with SUMO1 (Rattus norvegicus)
RHEA:64720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in)
REACT:R-BTA-375384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bombesin-like receptors bind bombesin homologues (Bos taurus)
REACT:R-BTA-5654612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)
RHEA:35841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cardiolipin + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA
RHEA:54116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + pseudolaratriene
RHEA:54116	skos:prefLabel	"pseudolaratriene synthase"
RHEA:54116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pseudolaratriene synthase"
REACT:R-RNO-2168079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASTL (GWL) phosphorylates ARPP19 (Rattus norvegicus)
REACT:R-SSC-187574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated p27/p21 by the 26S proteasome (Sus scrofa)
RHEA:49720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NAD(+) + violacein
RHEA:51205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-trans-leukotriene B4 + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH
RHEA:46350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O
RHEA:54454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in tRNA + H(+) + NADH => a 5,6-dihydrouridine in tRNA + NAD(+)
REACT:R-DME-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Drosophila melanogaster)
REACT:R-CEL-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
RHEA:18556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-tartrate + NAD(+) <=> dihydroxyfumarate + H(+) + NADH
REACT:R-RNO-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Rattus norvegicus)
EC:3.1.21.1	skos:prefLabel	"deoxyribonuclease I"
EC:3.1.21.1	skos:altLabel	"pancreatic DNase"
EC:3.1.21.1	skos:altLabel	"DNase"
EC:3.1.21.1	skos:altLabel	"thymonuclease"
EC:3.1.21.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyribonuclease I"
REACT:R-HSA-1977296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Homo sapiens)
REACT:R-CFA-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Canis familiaris)
REACT:R-SSC-9623384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-agonists bind ADRA1A,B,D (Sus scrofa)
RHEA:34266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + fumigaclavine A <=> diphosphate + fumigaclavine C
REACT:R-DME-372697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binding to p130cas (Drosophila melanogaster)
RHEA:56964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate
REACT:R-DME-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Drosophila melanogaster)
REACT:R-SCE-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)
RHEA:51753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4-prenylphloroglucinol + diphosphate
RHEA:19909	skos:altLabel	"cytochrome b2"
RHEA:19909	skos:altLabel	"L-lactate ferricytochrome c oxidoreductase"
RHEA:19909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-lactate dehydrogenase (cytochrome)"
RHEA:19909	skos:prefLabel	"L-lactate dehydrogenase (cytochrome)"
RHEA:19909	skos:altLabel	"lactic acid dehydrogenase"
RHEA:19909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate
GO:0046572	skos:altLabel	"versiconal cyclase"
GO:0046572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S-3S)-versiconal hemiacetal = H2O + versicolorin B
GO:0046572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	versicolorin B synthase activity
GO:0046572	skos:prefLabel	"versicolorin B synthase"
GO:0046572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"versicolorin B synthase"
GO:0002196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ser-tRNA(Ala) hydrolase activity
REACT:R-BTA-176646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Bos taurus)
REACT:R-DDI-194642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Dictyostelium discoideum)
REACT:R-RNO-3769393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ binds p-CBY:CTNNB1 (Rattus norvegicus)
RHEA:57138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine
RHEA:23322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(2)-malonyl-D-tryptophan => D-tryptophan + malonyl-CoA
REACT:R-XTR-74726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of insulin from insulin receptor (Xenopus tropicalis)
RHEA:30200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:55100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxypentanoyl-[ACP] + NADP(+)
REACT:R-HSA-201639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of GAS2 (Homo sapiens)
RHEA:22125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-O-acetylajmaline + H2O => acetate + ajmaline + H(+)
REACT:R-DME-5661290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Drosophila melanogaster)
REACT:R-XTR-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Xenopus tropicalis)
GO:0033914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylan 1,3-beta-xylosidase activity
GO:0033914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,3'-xylanase activity
GO:0033914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-beta-1,3'-xylanase activity
GO:0033914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity
GO:0033914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-1,3-beta-xylosidase activity
GO:0033914	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-beta-D-xylan xylohydrolase activity
RHEA:16644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl ethyl ester + H2O <=> a long-chain fatty acid + ethanol + H(+)
RHEA:65641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine
REACT:R-CFA-4755536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS3 SUMOylates RELA with SUMO3 (Canis familiaris)
EC:5.3.3.23	skos:prefLabel	"S-methyl-5-thioribulose 1-phosphate isomerase"
EC:5.3.3.23	skos:altLabel	"5-methylthioribulose-1-phosphate isomerase"
EC:5.3.3.23	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-methyl-5-thioribulose 1-phosphate isomerase"
RHEA:59801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-BTA-4420083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Bos taurus)
RHEA:60198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2
RHEA:31176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-methylpropenoyl-CoA + H2O => (S)-3-hydroxyisobutanoyl-CoA
REACT:R-DRE-168440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Danio rerio)
REACT:R-HSA-9009378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive CCND1 gene expression (Homo sapiens)
RHEA:70804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate => 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate
REACT:R-SCE-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Saccharomyces cerevisiae)
RHEA:55899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + L-tryptophan + O2 <=> 5-chloro-L-tryptophan + FAD + 2 H2O
RHEA:38261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + propanoyl-CoA => (2R,3S)-beta-methylmalyl-CoA
RHEA:71422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)
RHEA:11020	skos:altLabel	"1D-myo-inositol-trisphosphate 3-kinase"
RHEA:11020	skos:prefLabel	"inositol-trisphosphate 3-kinase"
RHEA:11020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-trisphosphate 3-kinase"
RHEA:11020	skos:altLabel	"IP3K"
RHEA:11020	skos:altLabel	"IP3 3-kinase"
RHEA:11020	skos:altLabel	"Inositol 1,4,5-trisphosphate 3-kinase"
RHEA:11020	skos:altLabel	"Ins(1,4,5)P3 3-kinase"
RHEA:11020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)
RHEA:23720	skos:prefLabel	"propionyl-CoA carboxylase"
RHEA:23720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"propionyl-CoA carboxylase"
RHEA:23720	skos:altLabel	"PCCase"
RHEA:23720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + H(+) + phosphate
REACT:R-DRE-6807866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the ERGIC (Danio rerio)
REACT:R-RNO-390673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2,4 bind acetylcholine (Rattus norvegicus)
RHEA:44445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)
REACT:R-SSC-5618110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Sus scrofa)
RHEA:15824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + glycine <=> 2 AH2 + CO2 + hydrogen cyanide
RHEA:13128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glutathione disulfide <=> CoA-glutathione + glutathione
REACT:R-XTR-350604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Agmatine + H2O <=> putrescine + urea (Xenopus tropicalis)
RHEA:50327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:17466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + quercitrin => L-rhamnopyranose + quercetin
REACT:R-RNO-211950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 24-hydroxylates CTL (Rattus norvegicus)
RHEA:43460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA
GO:0004134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity
GO:0004134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextrin glycosyltransferase activity
GO:0004134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-alpha-glucanotransferase activity
GO:0004134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dextrin transglycosylase activity
GO:0004134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligo-1,4-1,4-glucantransferase activity
GO:0004134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-enzyme activity
GO:0004134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	debranching enzyme maltodextrin glycosyltransferase activity
GO:0004134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	disproportionating enzyme activity
GO:0004134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	amylomaltase activity
REACT:R-DME-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Drosophila melanogaster)
RHEA:61989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(72) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine
GO:0047167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-hexadecyl-2-acetylglycerol acyltransferase activity
GO:0047167	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity
GO:0047167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-alkyl-2-acetylglycerol O-acyltransferase activity
RHEA:16334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] => diphosphate + holo-[citrate lyase ACP]
RHEA:70537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+) => GDP-beta-L-fucose + L-seryl-[EGF-like domain protein]
RHEA:49605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) => 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH
RHEA:12205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-2022368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MME:Zn2+ hydrolyses AGT(34-42) (Bos taurus)
RHEA:23550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(966) in 16S rRNA + S-adenosyl-L-methionine
RHEA:15079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantetheine + CO2 => H(+) + N-[(R)-pantothenoyl]-L-cysteine
RHEA:46496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)
RHEA:26415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary aliphatic amine + H2O + O2 => a primary amine + an aldehyde + H2O2
GO:0047874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl-diphosphate phosphohydrolase activity
GO:0047874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl pyrophosphatase activity
GO:0047874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichol diphosphatase activity
GO:0047874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyldiphosphatase activity
GO:0047874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dolichyl diphosphate phosphohydrolase activity
GO:0120243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminopropanoate deaminase activity
GO:0120243	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-iminobutanoate/2-iminopropanoate deaminase
REACT:R-MMU-8850797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK13 (Mus musculus)
REACT:R-XTR-8852324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds PLK1 (Xenopus tropicalis)
REACT:R-GGA-9645524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose binds TIFA (Gallus gallus)
REACT:R-MMU-453104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)
REACT:R-SSC-1297338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of ADAM and B4GALT1 With ZP3 (Sus scrofa)
RHEA:24101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diisopropyl fluorophosphate + H2O => diisopropyl phosphate + fluoride + 2 H(+)
REACT:R-MMU-8939203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Mus musculus)
REACT:R-RNO-451347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JNK by DSCAM (Rattus norvegicus)
REACT:R-SSC-8851888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds SHC1-2 (Sus scrofa)
RHEA:38656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-tuliposide B => D-glucose + tulipalin B
RHEA:70680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(in) + H(+)(in) => glycine betaine(out) + H(+)(out)
RHEA:61077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-minovincinine + acetyl-CoA => (-)-echitovenine + CoA
GO:0008988	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gene ksgA methyltransferase
GO:0008988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity
GO:0008988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribosomal ribonucleate adenine 6-methyltransferase activity
GO:0008988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (adenine-N6-)-methyltransferase activity
GO:0008988	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ErmC 23S rRNA methyltransferase
GO:0008988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonucleic acid-adenine (N(6)) methylase activity
GO:0008988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonucleic acid-adenine (N6) methylase activity
GO:0008988	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity
REACT:R-BTA-8979071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B binds iron (Bos taurus)
REACT:R-GGA-2997723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates TP53BP1 with SUMO1 (Gallus gallus)
RHEA:59030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => (Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2
REACT:R-HSA-8944362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF/LEF:CTNNB1 bind canonical WNT target promoters (Homo sapiens)
REACT:R-DRE-5672843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1S1 (PRAS40) binds mTORC1 (Danio rerio)
REACT:R-SSC-77329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Sus scrofa)
RHEA:30830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
REACT:R-SSC-9647619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD forms ring‐shaped oligomers  (Sus scrofa)
RHEA:30235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH
REACT:R-DME-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Drosophila melanogaster)
RHEA:50033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine
REACT:R-DRE-8948228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Danio rerio)
GO:0106149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0106149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indole-3-carbonyl nitrile 4-hydroxylase"
GO:0106149	skos:altLabel	"CYP82C2"
GO:0106149	skos:prefLabel	"indole-3-carbonyl nitrile 4-hydroxylase"
GO:0106149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-carbonyl nitrile 4-hydroxylase activity
REACT:R-SSC-9750666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds ST (Sus scrofa)
RHEA:72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in) => UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out)
RHEA:55450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-200326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CK octamer] (Canis familiaris)
REACT:R-DME-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)
REACT:R-RNO-981535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) binds C3bBb, C4bC2a (Rattus norvegicus)
RHEA:17157	skos:prefLabel	"creatine kinase"
RHEA:17157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + creatine = ADP + H(+) + N-phosphocreatine
RHEA:17157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"creatine kinase"
REACT:R-XTR-9624778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD 12mer translocates from ER membrane to extracellular region (Xenopus tropicalis)
RHEA:28884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-threonine(in) => H(+)(out) + L-threonine(out)
REACT:R-BTA-3322009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Bos taurus)
REACT:R-MMU-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Mus musculus)
REACT:R-CEL-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Caenorhabditis elegans)
REACT:R-SPO-8848580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Schizosaccharomyces pombe)
GO:0047375	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Vi-polysaccharide deacetylase activity
GO:0047375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylgalactosaminoglycan deacetylase"
GO:0047375	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl galactosaminoglycan deacetylase activity
GO:0047375	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polysaccharide deacetylase activity
GO:0047375	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-galactosaminoglycan acetylhydrolase activity
GO:0047375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosaminoglycan deacetylase activity
GO:0047375	skos:prefLabel	"N-acetylgalactosaminoglycan deacetylase"
RHEA:61341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA
RHEA:32174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + phenylacetyl-CoA <=> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)
REACT:R-GGA-9691566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 binds nicorandil (Gallus gallus)
REACT:R-RNO-8942836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Rattus norvegicus)
RHEA:54069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + sesterfisherol
RHEA:16984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipate + NAD(+) <=> H(+) + maleylacetate + NADH
REACT:R-SSC-1675928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Sus scrofa)
REACT:R-SSC-1606583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Sus scrofa)
REACT:R-MMU-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Mus musculus)
REACT:R-HSA-266050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to LTC4 by LTC4S (Homo sapiens)
GO:0050013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantoate aldolase activity
GO:0050013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ketopantoaldolase activity
GO:0050013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)
GO:0050013	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydropantoate formaldehyde-lyase activity
RHEA:45416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)
REACT:R-HSA-9761815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2 and ATF4 bind the SLC7A11 gene (Homo sapiens)
REACT:R-HSA-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
REACT:R-GGA-9749971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Gallus gallus)
GO:0016772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring phosphorus-containing groups
GO:0016772	skos:prefLabel	"Transferring phosphorus-containing groups"
GO:0016772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring phosphorus-containing groups"
RHEA:64847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + benzoyl-CoA <=> (2E)-geranyl benzoate + CoA
REACT:R-XTR-9020282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Xenopus tropicalis)
RHEA:34353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranate + 2 H(+) + NADH => (2E)-geranial + H2O + NAD(+)
RHEA:29539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase"
RHEA:29539	skos:altLabel	"Dol-P-Man:Man8GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase"
RHEA:29539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
RHEA:29539	skos:prefLabel	"dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase"
REACT:R-SCE-202407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma1 hydrolyses PIP2 (Saccharomyces cerevisiae)
RHEA:28563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate
RHEA:72952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) + 2 Na(+)(out) => butanoate(in) + 2 Na(+)(in)
RHEA:57851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + scopoletin <=> CO2 + fraxetin + succinate
REACT:R-HSA-2399913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL binds to RBP2 (Homo sapiens)
REACT:R-HSA-4615933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of CBX5 with SUMO1 (Homo sapiens)
REACT:R-BTA-2022065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPGs are secreted (Bos taurus)
REACT:R-BTA-173720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7 translocates to the plasma membrane (Bos taurus)
RHEA:21749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + NADP(+) => H(+) + methylglyoxal + NADPH
REACT:R-DDI-8876454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND3 exchanges GTP for GDP on RAB12 (Dictyostelium discoideum)
REACT:R-CFA-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Canis familiaris)
REACT:R-BTA-8938217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the SWI/SNF complex (Bos taurus)
REACT:R-HSA-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Homo sapiens)
REACT:R-HSA-1168644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Homo sapiens)
RHEA:67130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+) => 5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH
REACT:R-DME-70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Drosophila melanogaster)
RHEA:61383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O <=> 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate
RHEA:35601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanal + H(+) + NADPH => NADP(+) + propane-1,3-diol
REACT:R-DRE-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Danio rerio)
REACT:R-GGA-177945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Gallus gallus)
RHEA:61260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamine + O2 = 2-oxoglutaramate + H2O2 + NH4(+)
REACT:R-SSC-6813626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEAP2 binds bacteria (Sus scrofa)
EC:3.5.1.110	skos:prefLabel	"ureidoacrylate amidohydrolase"
EC:3.5.1.110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ureidoacrylate amidohydrolase"
GO:0016362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activin receptor activity, type II
GO:0016362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II activin receptor activity
GO:0016362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II receptor phosphorylates type I receptor (Homo sapiens)
REACT:R-BTA-8952058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 binds RUNX3 and displaces EP300 (Bos taurus)
REACT:R-CFA-9673053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 transforms oleoyl-phe from oleate and phe (Canis familiaris)
RHEA:15791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-xylono-1,4-lactone + NADPH => L-xylose + NADP(+)
RHEA:68542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-alpha-cedrene + diphosphate => (2Z,6Z)-farnesyl diphosphate
REACT:R-RNO-2187405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 binds phosphorylated SMAD2/3 (Rattus norvegicus)
RHEA:39924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-octadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine
REACT:R-DME-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Drosophila melanogaster)
RHEA:57407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + narcotine hemiacetal <=> H(+) + NADH + noscapine
RHEA:60113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + H2O
REACT:R-RNO-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Rattus norvegicus)
REACT:R-BTA-9011949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Bos taurus)
REACT:R-DME-879674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD97 binds CD55 (Drosophila melanogaster)
REACT:R-CFA-5693542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RPA complexes with ssDNA at resected DNA DSBs (Canis familiaris)
RHEA:50106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetradecanoyl-taurine => taurine + tetradecanoyl-CoA
GO:0102067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate reductase activity
REACT:R-MMU-71783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Mus musculus)
RHEA:10241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-[ACP] + NAD(+) => a (2E)-enoyl-[ACP] + H(+) + NADH
REACT:R-DRE-5686072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-3Y-SHC1 dissociates from IGF1R (Danio rerio)
GO:0043872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine/cadaverine antiporter activity
GO:0043872	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cadaverine transmembrane transporter activity
GO:0043872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine-cadaverine antiporter activity
GO:0043872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine:lysine antiporter activity
GO:0043872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine:cadaverine antiporter activity
REACT:R-SPO-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Schizosaccharomyces pombe)
REACT:R-MMU-9664883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 translocates from cytosol to peroxisomal membrane (Mus musculus)
RHEA:57778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chloro-3-methylcatechol + NAD(+) + nitrite => 2-chloro-6-nitrotoluene + NADH + O2
GO:0062158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride:proton antiporter activity
REACT:R-GGA-1227698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 inhibits IPS1 signaling (Gallus gallus)
EC:1.7.99.-	skos:prefLabel	"With other acceptors"
EC:1.7.99.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other acceptors"
REACT:R-MMU-5218815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds NCK (Mus musculus)
RHEA:27904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,7-trimethylurate + ubiquinol-0 => caffeine + H2O + ubiquinone-0
REACT:R-MMU-5653786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 deISGylates ISG:K164,ISG:K168-PCNA (Mus musculus)
REACT:R-GGA-5661230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds arsenic (Gallus gallus)
RHEA:29555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + 2 H(+) + UMP
REACT:R-DME-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Drosophila melanogaster)
REACT:R-HSA-2179413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC-alpha  activate MMP3 (Homo sapiens)
REACT:R-MMU-9664892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SQSTM1 binds ATM dimer:Ub-p-PEX5 (Mus musculus)
REACT:R-DRE-114558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate Gq (Danio rerio)
REACT:R-XTR-166220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion diffuses laterally to UCP (Xenopus tropicalis)
RHEA:24527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CFA-188386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Rb with Cyclin E:Cdk2 complexes (Canis familiaris)
RHEA:27290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate dehydrogenase (acceptor)"
RHEA:27290	skos:altLabel	"formate dehydrogenase O"
RHEA:27290	skos:altLabel	"formate dehydrogenase H"
RHEA:27290	skos:prefLabel	"formate dehydrogenase (acceptor)"
RHEA:27290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + formate + H(+) = AH2 + CO2
RHEA:62144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + dGTP = 2 dGDP
REACT:R-GGA-8853429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLDA1 binds AURKA (Gallus gallus)
REACT:R-HSA-8935740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
RHEA:59502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O
REACT:R-RNO-8949580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F1Fo ATP synthase dimerizes (Rattus norvegicus)
RHEA:31480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol A + UDP-alpha-D-glucuronate => H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP
REACT:R-GGA-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Gallus gallus)
REACT:R-XTR-8857577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 facilitates PTK6 autophosphorylation (Xenopus tropicalis)
RHEA:26073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucuronate = D-glucuronate + H(+) + UDP
RHEA:19693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH
RHEA:19693	skos:prefLabel	"5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase"
RHEA:19693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase"
RHEA:50883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol <=> 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)
REACT:R-CFA-9668831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CST complex formation (Canis familiaris)
RHEA:33861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + versicolorin B => (2S-3S)-versiconal hemiacetal
RHEA:27356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H(+) + rebeccamycin + S-adenosyl-L-homocysteine
GO:0102791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfuretin synthase activity
REACT:R-HSA-209566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is auto-ubiquitinated (Homo sapiens)
REACT:R-CEL-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Caenorhabditis elegans)
GO:0008419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA lariat debranching enzyme activity
REACT:R-HSA-71239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Homo sapiens)
REACT:R-DME-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Drosophila melanogaster)
RHEA:43539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 D-glyceraldehyde 3-phosphate <=> 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate
REACT:R-SSC-9703895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds CASR agonists (Sus scrofa)
RHEA:15903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate => (2R)-2-phosphoglycerate
RHEA:69359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hypobromite + L-tyrosyl-[protein] <=> 3-bromo-L-tyrosyl-[protein] + H2O
GO:0047122	skos:prefLabel	"quinaldate 4-oxidoreductase"
GO:0047122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"quinaldate 4-oxidoreductase"
GO:0047122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)
GO:0047122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinaldate 4-oxidoreductase activity
GO:0047122	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinaldic acid 4-oxidoreductase activity
GO:0047122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinaldate = AH2 + kynurenate
GO:0047122	skos:altLabel	"quinaldic acid 4-oxidoreductase"
REACT:R-BTA-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Bos taurus)
RHEA:72918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructopyranose(out) + Na(+)(out) <=> D-fructopyranose(in) + Na(+)(in)
RHEA:36599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + NAD(+) = NADH + sulfur
REACT:R-CFA-9700662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Canis familiaris)
REACT:R-GGA-9692738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds HRH2 antagonists (Gallus gallus)
REACT:R-DRE-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Danio rerio)
REACT:R-HSA-9665315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 T733I does not bind tesevatinib (Homo sapiens)
REACT:R-CFA-2187401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
REACT:R-XTR-2468293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Xenopus tropicalis)
REACT:R-BTA-5696947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP47 deubiquitinates POLB (Bos taurus)
REACT:R-BTA-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Bos taurus)
REACT:R-MMU-8870346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Mus musculus)
RHEA:24788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)
REACT:R-HSA-1675896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane (Homo sapiens)
REACT:R-DRE-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Danio rerio)
RHEA:16170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate
REACT:R-DRE-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Danio rerio)
REACT:R-GGA-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Gallus gallus)
RHEA:12242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+) => acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH
REACT:R-CFA-8938073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Canis familiaris)
RHEA:46429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]
RHEA:54031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-442938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated MAPK3/MAPK6 migrates to nucleus (Gallus gallus)
RHEA:22028	skos:altLabel	"taxadienol acetyltransferase"
RHEA:22028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taxadien-5alpha-ol O-acetyltransferase"
RHEA:22028	skos:prefLabel	"taxadien-5alpha-ol O-acetyltransferase"
RHEA:22028	skos:altLabel	"taxa-4(20),11(12)-dien-5alpha-ol O-acetyltransferase"
RHEA:22028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate
RHEA:53972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
RHEA:13042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopachrome => 5,6-dihydroxyindole-2-carboxylate
RHEA:15126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) => CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)
REACT:R-MMU-1483002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to 1-acyl GO3P by GNPAT (Mus musculus)
EC:3.4.21.54	skos:prefLabel	"gamma-renin"
EC:3.4.21.54	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-renin"
RHEA:13683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine
REACT:R-DRE-5690988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-incision of DNA by ERCC5 (XPG) in GG-NER (Danio rerio)
REACT:R-HSA-9008456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A gene expression is inhibited by RUNX2 (Homo sapiens)
REACT:R-CFA-8858498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SL (surrogate light chain) binds IgH to form pre-BCR (Canis familiaris)
REACT:R-RNO-2990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO1 to UBA2:SAE1 (Rattus norvegicus)
REACT:R-SSC-2424486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)
RHEA:39963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate
RHEA:33433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-2-oxohex-3-enedioate => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate
RHEA:24491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:51431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + aminomethylphosphonate <=> 2-N-acetamidomethylphosphonate + CoA
REACT:R-DRE-3341296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX7,8 catalyze peroxidation of P4HB (PDI) (Danio rerio)
RHEA:65121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione => L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine
GO:0004047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T-protein
GO:0004047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
GO:0004047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrahydrofolate aminomethyltransferase activity
GO:0004047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminomethyltransferase activity
GO:0004047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine-cleavage system T-protein activity
GO:0004047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycine synthase activity
GO:0004047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
GO:0004047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
REACT:R-GGA-352840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose + ATP => glucose 6-phosphate + ADP (Gallus gallus)
RHEA:65733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + heptyl sulfate + O2 => CO2 + H(+) + heptanal + succinate + sulfate
RHEA:35996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-379893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)
RHEA:68094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+) => a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA
RHEA:33372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]
REACT:R-DRE-6800797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome activates CASP2 (Danio rerio)
REACT:R-DDI-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)
REACT:R-XTR-6811433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Xenopus tropicalis)
REACT:R-XTR-6786239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)
GO:0061799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic pyranopterin monophosphate synthase activity
REACT:R-DDI-6785928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHAC1,2 cleaves GSH to OPRO and CysGly (Dictyostelium discoideum)
REACT:R-SSC-266050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to LTC4 by LTC4S (Sus scrofa)
REACT:R-DRE-373791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Danio rerio)
REACT:R-BTA-216043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II binds integrin alpha10beta1 (Bos taurus)
RHEA:68963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxycoumarin + S-adenosyl-L-methionine <=> 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-9014766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Bos taurus)
REACT:R-CFA-4420202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 disassociates from VEGFR2 and translocate to PM (Canis familiaris)
RHEA:52919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:62979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienamide + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + NH4(+)
RHEA:70488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 => a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate
REACT:R-XTR-5591086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA5 binds activated protein C (Xenopus tropicalis)
RHEA:40501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O
RHEA:66814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B => 5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH
RHEA:45124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acarbose + ATP = acarbose 7(IV)-phosphate + ADP + H(+)
RHEA:45124	skos:prefLabel	"acarbose 7(IV)-phosphotransferase"
RHEA:45124	skos:altLabel	"acarbose 7-kinase"
RHEA:45124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acarbose 7(IV)-phosphotransferase"
REACT:R-DRE-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Danio rerio)
REACT:R-XTR-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Xenopus tropicalis)
REACT:R-RNO-9664855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)
REACT:R-SSC-8944233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIX (Sus scrofa)
RHEA:43885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH
GO:0018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gallate decarboxylase activity
GO:0018798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gallate carboxy-lyase (pyrogallol-forming)
GO:0018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gallic acid decarboxylase activity
GO:0018798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gallate carboxy-lyase activity
REACT:R-HSA-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Homo sapiens)
REACT:R-CFA-9648114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 recruits NUDC to mitotic spindle (Canis familiaris)
RHEA:51569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CEL-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Caenorhabditis elegans)
REACT:R-CFA-5578783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Canis familiaris)
RHEA:22246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + kaempferol 3-O-beta-D-xyloside + UDP => kaempferol + UDP-alpha-D-xylose
RHEA:58402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptanal + NADPH => heptan-1-ol + NADP(+)
REACT:R-DME-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Drosophila melanogaster)
RHEA:30019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + lipid A-core
REACT:R-DME-190265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds to FGF (Drosophila melanogaster)
REACT:R-XTR-2187388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Xenopus tropicalis)
RHEA:20302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arginine + tRNA(Arg) => AMP + diphosphate + L-arginyl-tRNA(Arg)
REACT:R-RNO-2076392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcA to heparan (Rattus norvegicus)
RHEA:34234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-nitrosalicylate + O2 <=> 4-nitro-6-oxohepta-2,4-dienedioate + H(+)
REACT:R-DRE-6801776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A binds bacterial phospholipids (Danio rerio)
REACT:R-MMU-8862700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMKLR1 binds Resolvin E1 (Mus musculus)
RHEA:11046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a halide anion + glycolate + H(+) => a haloacetate + H2O
REACT:R-RNO-380283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Rattus norvegicus)
REACT:R-DDI-8876319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC50A1 transports Glc from cytosol to extracellular region (Dictyostelium discoideum)
REACT:R-SPO-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Schizosaccharomyces pombe)
GO:0030172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	troponin C binding
RHEA:54922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinal + H(+) + NADPH => 13-cis-retinol + NADP(+)
REACT:R-BTA-419843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCA(83-119) binds CALCR (Bos taurus)
RHEA:47233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-HSA-9754974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADK phosphorylates RBV (Homo sapiens)
REACT:R-XTR-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Xenopus tropicalis)
RHEA:36929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA
REACT:R-MMU-166542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-NGF dimer binds to TrkA receptor (Mus musculus)
REACT:R-HSA-167113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition (Homo sapiens)
GO:0022852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine-gated chloride ion channel activity
REACT:R-XTR-2250301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyrrole cross-links (Xenopus tropicalis)
GO:0102755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity
RHEA:35487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:55345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol => 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA
REACT:R-CEL-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Caenorhabditis elegans)
REACT:R-DME-8877941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SMAD1 in the nucleus (Drosophila melanogaster)
REACT:R-GGA-975097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
RHEA:27310	skos:altLabel	"1,2-DHN dioxygenase"
RHEA:27310	skos:altLabel	"DHNDO"
RHEA:27310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthalene-1,2-diol + O2 = 2-hydroxychromene-2-carboxylate + H(+)
RHEA:27310	skos:altLabel	"1,2-dihydroxynaphthalene oxygenase"
RHEA:27310	skos:prefLabel	"1,2-dihydroxynaphthalene dioxygenase"
RHEA:27310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,2-dihydroxynaphthalene dioxygenase"
REACT:R-PFA-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Plasmodium falciparum)
REACT:R-HSA-6808487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)
REACT:R-CFA-201443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type II receptor phosphorylates type I receptor (Canis familiaris)
REACT:R-BTA-446372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of  PARVA with TESK1 (Bos taurus)
REACT:R-RNO-68954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm2-7 is phosphorylated by DDK (Rattus norvegicus)
REACT:R-RNO-212713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)
RHEA:29056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + 2 H(+)(in) + H2 => a ubiquinol + 2 H(+)(out)
GO:0047539	skos:prefLabel	"2-deoxyglucosidase"
GO:0047539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-deoxy-alpha-D-glucosidase activity
GO:0047539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-deoxy-alpha-D-glucoside + H2O = 2-deoxy-D-glucose + an alcohol
GO:0047539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-deoxyglucosidase"
GO:0047539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity
GO:0047539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxyglucosidase activity
GO:0047539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-deoxy-alpha-glucosidase activity
RHEA:30079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate
REACT:R-HSA-195690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Homo sapiens)
RHEA:68606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydroxyacetone + sulfite => (2S)-3-sulfopropanediol
RHEA:20324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NAD(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADH
RHEA:62819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 monapinone E + O2 <=> 2 dinapinone E + 2 H2O
RHEA:26512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-proline + NH4(+) => H2O + L-prolinamide
GO:0042657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	major histocompatibility complex class II protein binding, via lateral surface
GO:0042657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II protein binding, via lateral surface
REACT:R-HSA-9649108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer binds 5HT (Homo sapiens)
REACT:R-MMU-193961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Mus musculus)
RHEA:29051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + H2 + menaquinone-8 = 2 H(+)(out) + menaquinol-8
REACT:R-HSA-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)
REACT:R-GGA-8985900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Gallus gallus)
EC:3.6.1.64	skos:altLabel	"(deoxy)inosine diphosphatase"
EC:3.6.1.64	skos:prefLabel	"inosine diphosphate phosphatase"
EC:3.6.1.64	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inosine diphosphate phosphatase"
EC:1.18.1.2	skos:prefLabel	"ferredoxin--NADP(+) reductase"
EC:1.18.1.2	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ferredoxin--NADP(+) reductase"
RHEA:51001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine => [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine
REACT:R-HSA-9031856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfido conjugates translocate from cytosol to extracellular region (Homo sapiens)
GO:0140795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3R2 arginine deiminase activity
GO:0140795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine deiminase activity (H3-R2 specific)
GO:0140795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3-R2 citrullination
GO:0140795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-R2 arginine deiminase activity
REACT:R-MMU-5693580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)
RHEA:20382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH
RHEA:71390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-pipecolate(in) + Na(+)(in) <=> L-pipecolate(out) + Na(+)(out)
REACT:R-CFA-9038052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GREB1 binds ESR1:ESTG and co-activators (Canis familiaris)
REACT:R-BTA-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Bos taurus)
RHEA:68990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
GO:0019137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinigrase activity
GO:0019137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sinigrinase activity
GO:0019137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioglucosidase activity
GO:0019137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioglucoside glucohydrolase activity
GO:0019137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myrosinase activity
REACT:R-DRE-209891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine is oxidised to noradrenaline (Danio rerio)
REACT:R-SSC-5686335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF2RA:CSF2RB binds SFTPs (Sus scrofa)
REACT:R-HSA-9026531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y817 of p-5Y-NTRK2 recruits PLCG1 (Homo sapiens)
REACT:R-BTA-9674127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Bos taurus)
REACT:R-DRE-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Danio rerio)
RHEA:24512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrazolylalanine synthase"
RHEA:24512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O
RHEA:24512	skos:prefLabel	"pyrazolylalanine synthase"
REACT:R-DRE-1112755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds IL6ST (Danio rerio)
GO:0018626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)
GO:0018626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chlorobenzoate 1,2-dioxygenase activity
GO:0018626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-halobenzoate 1,2-dioxygenase activity
RHEA:67091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + tetracosanoate(in) <=> ADP + H(+) + phosphate + tetracosanoate(out)
REACT:R-HSA-8878702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BMAL1:p-CLOCK,NPAS2 binds KLF15 gene (Homo sapiens)
RHEA:19224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 formaldehyde + H2O <=> formate + H(+) + methanol
REACT:R-DME-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Drosophila melanogaster)
REACT:R-HSA-167196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
RHEA:22359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + oxaloacetate <=> CO2 + phosphate + phosphoenolpyruvate
RHEA:56423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[D-alanyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]
REACT:R-BTA-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Bos taurus)
RHEA:44450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxoacyl-[ACP] + CO2 + CoA => an acyl-CoA + H(+) + malonyl-[ACP]
REACT:R-HSA-202110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
REACT:R-RNO-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Rattus norvegicus)
RHEA:54379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O <=> diphosphate + nezukol
REACT:R-DME-170057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)
RHEA:49819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Fe(III)-[cytochrome c] + H2O + hydrazine <=> 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide
RHEA:48353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
REACT:R-CFA-2530445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD59 inhibits MAC formation (Canis familiaris)
REACT:R-DME-442422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-HSA-8950674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27 translocates from the cytosol to the extracellular space (Homo sapiens)
RHEA:36233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O
REACT:R-SSC-9008258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 binds ESR1:estrogen:TFGA gene (Sus scrofa)
REACT:R-DDI-351207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spermine  => N-acetylated spermine (Dictyostelium discoideum)
REACT:R-BTA-5682967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 binds DNA DSBs (Bos taurus)
RHEA:33595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine
GO:0047222	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity
GO:0047222	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity
GO:0047222	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-N-acetylglucosaminyltransferase activity
GO:0047222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity
REACT:R-SSC-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Sus scrofa)
REACT:R-HSA-8878013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 and SMAD1 complex binds the SMAD6 gene promoter (Homo sapiens)
RHEA:68303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + tetradecanoyl-CoA <=> CoA + O-tetradecanoyl-L-seryl-[protein]
REACT:R-RNO-204779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang1 (Rattus norvegicus)
RHEA:53977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
RHEA:45555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine
RHEA:18782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA => acetyl-CoA + CO2
RHEA:29464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K(+)(in) => K(+)(out)
RHEA:44285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 malonyl-CoA + octanoyl-CoA => 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA
GO:0018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrophloroglucinol hydrolase activity
REACT:R-HSA-5668454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
REACT:R-DRE-8982019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (i)–i1/i2/i3 binds RGS proteins (Danio rerio)
RHEA:68074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-thiazolidine-2-carboxylate + NADP(+) => Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH
REACT:R-BTA-6786110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL13-bound IL13R type II (Bos taurus)
REACT:R-XTR-1482776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Xenopus tropicalis)
REACT:R-DME-4608855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRICKLE1 is degraded by the proteasome (Drosophila melanogaster)
REACT:R-HSA-420580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:PVRL3 trans heterodimer formation (Homo sapiens)
RHEA:46244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"palmitoyl-CoA 14-(E/Z)-desaturase"
RHEA:46244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46244	skos:prefLabel	"palmitoyl-CoA 14-(E/Z)-desaturase"
RHEA:48985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + glyoxylate + succinate
REACT:R-DME-432483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination (Drosophila melanogaster)
GO:0140658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleosome-dependent ATPase activity
GO:0140658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleosome-activated ATPase activity
GO:0140658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent chromatin remodeler activity
GO:0140658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis-dependent chromatin remodeler activity
GO:0140658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-dependent chromatin remodeler activity
REACT:R-DME-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Drosophila melanogaster)
GO:0061596	skos:prefLabel	"sulfolactaldehyde 3-reductase"
GO:0061596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfopropanediol + NAD(+) = (2S)-3-sulfolactaldehyde + H(+) + NADH
GO:0061596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfolactaldehyde 3-reductase"
GO:0061596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfolactaldehyde reductase activity
GO:0103081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiopropylmalate dehydrogenase activity
RHEA:47415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA
RHEA:62665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'R)-atrovenetin + S-adenosyl-L-methionine => deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine
RHEA:11934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + hydrogen cyanide => 2-hydroxy-2-methylpropanenitrile
REACT:R-RNO-917987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFRC dimer binds 2xholoTF (Rattus norvegicus)
REACT:R-HSA-111916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of p-S133-CREB1 (Homo sapiens)
RHEA:25331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH
GO:0018649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydrofuran hydroxylase activity
RHEA:26020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O => beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate
REACT:R-MMU-197235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)
REACT:R-CEL-1482889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is acylated to TAG by DGAT1/2 (Caenorhabditis elegans)
REACT:R-BTA-1855166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)
GO:0008936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamidase activity
GO:0008936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	YNDase activity
GO:0008936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotine deamidase activity
GO:0008936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAMase activity
GO:0008936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide amidohydrolase activity
GO:0008936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide deaminase activity
GO:0008936	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide amidase activity
REACT:R-RNO-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Rattus norvegicus)
RHEA:42643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-demethylmenaquinol + S-adenosyl-L-methionine <=> a menaquinol + H(+) + S-adenosyl-L-homocysteine
GO:1990756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin ligase substrate adaptor
GO:1990756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin ligase-substrate adaptor activity
GO:1990756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein binding, bridging involved in substrate recognition for ubiquitination
REACT:R-DDI-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Dictyostelium discoideum)
RHEA:55926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-191999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Danio rerio)
RHEA:22648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[cytochrome c] = apo-[cytochrome c] + heme b
RHEA:22648	skos:prefLabel	"holocytochrome-c synthase"
RHEA:22648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"holocytochrome-c synthase"
RHEA:22648	skos:altLabel	"cytochrome c heme-lyase"
RHEA:22648	skos:altLabel	"cytochrome c synthase"
REACT:R-DRE-1168459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lyn activates ERK (Danio rerio)
RHEA:50913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)
REACT:R-DRE-8869667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxLDL:CD36 binds TLR4:TLR6 (Danio rerio)
REACT:R-MMU-9750666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds ST (Mus musculus)
GO:0017005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-tyrosyl-DNA phosphodiesterase activity
REACT:R-BTA-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Bos taurus)
REACT:R-SSC-9695890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Sus scrofa)
REACT:R-MMU-73635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Mus musculus)
GO:0102195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity
REACT:R-MMU-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Mus musculus)
REACT:R-RNO-350600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme inhibitor binds to OAZ and stablizes ODC complex (Rattus norvegicus)
RHEA:38324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol
REACT:R-DRE-202723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha5beta1 binds FN1 dimer (Danio rerio)
RHEA:69702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O <=> beta-D-glucose + N-hexadecanoylsphing-4-enine
REACT:R-HSA-9672177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)
REACT:R-CFA-9008928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Canis familiaris)
EC:3.4.14.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dipeptidyl-dipeptidase"
EC:3.4.14.6	skos:altLabel	"tetrapeptide dipeptidase"
EC:3.4.14.6	skos:prefLabel	"dipeptidyl-dipeptidase"
EC:3.4.14.6	skos:altLabel	"dipeptidyl tetrapeptide hydrolase"
EC:3.4.14.6	skos:altLabel	"dipeptidyl ligase"
REACT:R-DDI-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Dictyostelium discoideum)
RHEA:39275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH = (15Z)-tetracosenoyl-CoA + NADP(+)
RHEA:59246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ADP-D-ribose + H(+) => 3''-O-acetyl-ADP-D-ribose + H2O
RHEA:27946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)
REACT:R-BTA-73814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)
RHEA:45017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine => L-selenomethionine + tetrahydropteroyltri-L-glutamate
REACT:R-SCE-9013198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Saccharomyces cerevisiae)
RHEA:60170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl monophosphate + ADP => a fatty acid + ATP
REACT:R-BTA-4720432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Bos taurus)
GO:0047620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylglycerol kinase activity
GO:0047620	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoacylglycerol kinase activity
GO:0047620	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:acylglycerol 3-phosphotransferase activity
GO:0047620	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoglyceride phosphokinase activity
GO:0047620	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-2-monoacylglycerol kinase activity
GO:0047620	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MGK
GO:0047620	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoglyceride kinase activity
GO:0047620	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	monoacylglycerol kinase (phosphorylating)
REACT:R-HSA-8964619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds ARHGEF6 (Homo sapiens)
REACT:R-HSA-9012205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive CHD1 gene transcription (Homo sapiens)
REACT:R-XTR-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Xenopus tropicalis)
RHEA:30789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2
RHEA:14162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
GO:0048032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galacturonate binding
GO:0048032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galacturonic acid binding
RHEA:33419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate
RHEA:33419	skos:prefLabel	"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase"
RHEA:33419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase"
RHEA:33419	skos:altLabel	"2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase"
RHEA:18118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosine + O2 => H2O + L-dopaquinone
RHEA:46265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0044824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' processing reaction
GO:0044824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-processing activity
GO:0044824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retroviral 3' processing activity
RHEA:71730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + fumarate(in) <=> citrate(in) + fumarate(out)
REACT:R-XTR-77608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of A1CF to stem-looped RNA (Xenopus tropicalis)
REACT:R-HSA-1912379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of fringe-modified NOTCH to plasma membrane (Homo sapiens)
REACT:R-RNO-199579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR2DL4 interacting with HLA-G (Rattus norvegicus)
REACT:R-HSA-449976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)
RHEA:59529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]
REACT:R-CEL-420980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)
RHEA:66629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 => (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2
REACT:R-DRE-6804099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LTP (Danio rerio)
REACT:R-DRE-6807008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates MET (Danio rerio)
RHEA:50898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate => 8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O
REACT:R-DRE-114552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate G12/13 (Danio rerio)
REACT:R-CEL-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Caenorhabditis elegans)
REACT:R-BTA-5696007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF3 ligates CoA-SH to VLCFA (Bos taurus)
REACT:R-DRE-8980228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Danio rerio)
RHEA:34081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+)
REACT:R-DRE-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Danio rerio)
EC:3.1.11.6	skos:prefLabel	"exodeoxyribonuclease VII"
EC:3.1.11.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"exodeoxyribonuclease VII"
EC:3.1.11.6	skos:altLabel	"E.coli exonuclease VII"
EC:3.1.11.6	skos:altLabel	"exonuclease VII"
REACT:R-SSC-5694415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC24A,B:SEC23A bind SEC22B (Sus scrofa)
REACT:R-SCE-5082409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of HSF1:HSP90 complex in the nucleus (Saccharomyces cerevisiae)
REACT:R-XTR-8983300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Xenopus tropicalis)
RHEA:65055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trifluoromethyl)benzyl alcohol + NAD(+) <=> 4-(trifluoromethyl)benzaldehyde + H(+) + NADH
REACT:R-SCE-5082384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70:DNAJB1 binds HSF1 (Saccharomyces cerevisiae)
REACT:R-SSC-975340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Sus scrofa)
REACT:R-BTA-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Bos taurus)
REACT:R-BTA-5617143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Bos taurus)
REACT:R-XTR-8948219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLOD3 binds Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)
REACT:R-SCE-6814833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Saccharomyces cerevisiae)
REACT:R-DRE-201425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Danio rerio)
RHEA:39891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + H(+) + vancomycin
RHEA:39891	skos:altLabel	"devancosamine-vancomycin TDP-vancosaminyltransferase"
RHEA:39891	skos:prefLabel	"devancosaminyl-vancomycin vancosaminetransferase"
RHEA:39891	skos:altLabel	"desvancosaminyl-vancomycin vancosaminetransferase"
RHEA:39891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"devancosaminyl-vancomycin vancosaminetransferase"
REACT:R-CFA-936802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)
REACT:R-MMU-9698408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates active FLT3 (Mus musculus)
REACT:R-SPO-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Schizosaccharomyces pombe)
RHEA:44751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(beta-D-ribosyl)imidazole + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)
REACT:R-CEL-8953461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Caenorhabditis elegans)
REACT:R-SSC-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Sus scrofa)
RHEA:57171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2
RHEA:12975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP => AMP + ATP
GO:0052806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite:reduced coenzyme F420 reductase activity
GO:0052806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-sulfite reductase activity
GO:0052806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen-sulfide:coenzyme F420 oxidoreductase activity
GO:0052806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfite reductase (coenzyme F420) activity
GO:0052806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent sulfite reductase activity
REACT:R-DRE-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Danio rerio)
RHEA:47054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:44637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dinitroanisole + H2O => 2,4-dinitrophenol + H(+) + methanol
RHEA:51464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-9647980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature RAS proteins translocate to plasma membrane (Caenorhabditis elegans)
RHEA:43285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate
REACT:R-RNO-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Rattus norvegicus)
REACT:R-RNO-5690196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates RNF128 (Rattus norvegicus)
REACT:R-GGA-449829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11 binds IL11RA (Gallus gallus)
RHEA:49445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminobenzoyl)acetyl-CoA + H2O => (2-aminobenzoyl)acetate + CoA + H(+)
RHEA:64680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + ethanol = CoA + ethyl benzoate
GO:0033820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity
GO:0033820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T6-HMC-alpha-glucosyl transferase activity
GO:0033820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T4-HMC-alpha-glucosyl transferase activity
GO:0033820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA alpha-glucosyltransferase activity
GO:0033820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-DNA alpha-glucosyltransferase activity
GO:0033820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:DNA alpha-D-glucosyltransferase activity
GO:0033820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T2-HMC-alpha-glucosyl transferase activity
RHEA:25361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin]
RHEA:22494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formamide + L-glutamate => H2O + N-formimidoyl-L-glutamate
REACT:R-CEL-5334050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Caenorhabditis elegans)
REACT:R-BTA-1855159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Bos taurus)
REACT:R-SPO-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Schizosaccharomyces pombe)
REACT:R-RNO-5357860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Rattus norvegicus)
RHEA:57638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate
RHEA:54775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate
RHEA:46076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-eicosenoyl-CoA + H(+) + NADH = eicosanoyl-CoA + NAD(+)
RHEA:63132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione
RHEA:69831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campestanol + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5654605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS3 (Danio rerio)
REACT:R-SSC-2031355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
RHEA:18507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+) => L-lysine + NAD(+)
RHEA:51396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin = CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin
REACT:R-HSA-5138441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A-FZD4 recruits DVL2 (Homo sapiens)
RHEA:41491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine
REACT:R-HSA-349638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of SR-BI-bound spherical HDL (Homo sapiens)
RHEA:46529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SCE-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Saccharomyces cerevisiae)
REACT:R-SSC-158251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)
REACT:R-HSA-416639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)
REACT:R-DME-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Drosophila melanogaster)
REACT:R-SSC-74986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of pre-rRNA transcript (Sus scrofa)
RHEA:46558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2
REACT:R-GGA-5689111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 autoubiquitinates (Gallus gallus)
RHEA:22905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) => H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)
RHEA:44329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octanoylglycerol + H2O => glycerol + H(+) + octanoate
RHEA:38402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)
RHEA:43297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate
REACT:R-RNO-5607731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome processes p-7S-p100:RELB to form p52:RELB (Rattus norvegicus)
REACT:R-MMU-8866553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded CFTR is degraded by the 26S proteasome (Mus musculus)
RHEA:46492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)
REACT:R-SCE-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Saccharomyces cerevisiae)
REACT:R-HSA-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Homo sapiens)
RHEA:11914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin E2 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+)
RHEA:16520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-1-aminopropan-2-ol + NAD(+) <=> aminoacetone + H(+) + NADH
REACT:R-RNO-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Rattus norvegicus)
REACT:R-XTR-2484822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore assembly (Xenopus tropicalis)
RHEA:63727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	candesartan + UDP-alpha-D-glucuronate <=> candesartan O-beta-D-glucuronoside + UDP
REACT:R-SSC-6807105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitinated PTEN translocates to the nucleus (Sus scrofa)
RHEA:70647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine(out) + H(+)(out) = D-serine(in) + H(+)(in)
REACT:R-MMU-391158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRP alpha binds CD47 (Mus musculus)
RHEA:41558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2
REACT:R-BTA-6787757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates acidic AAs (Bos taurus)
REACT:R-GGA-9626816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds p-S345-NCF1 (Gallus gallus)
REACT:R-DRE-5683077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate KDM4A,B (Danio rerio)
REACT:R-HSA-5676607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF,sAPRIL binds TACI,BCMA (Homo sapiens)
REACT:R-DRE-212352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ARC coactivator complex (Danio rerio)
RHEA:43586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + NH4(+) => H2O + iminoarginine
RHEA:43047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecasphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylhexadecasphinganine
GO:0140485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate(in) = 5-aminolevulinate(out)
GO:0140485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinic acid transmembrane transporter activity
REACT:R-MMU-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Mus musculus)
REACT:R-DRE-3257122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane (Danio rerio)
REACT:R-BTA-9025996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Bos taurus)
REACT:R-GGA-4093327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHA binds TIAM1 (Gallus gallus)
GO:0047504	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	monoterpenoid dehydrogenase activity
GO:0047504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-menthol:NADP+ oxidoreductase activity
GO:0047504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthol dehydrogenase activity
REACT:R-XTR-1606564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Xenopus tropicalis)
RHEA:51256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 = (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate
REACT:R-RNO-2161549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by AKR1C3 (Rattus norvegicus)
GO:0047506	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:(d)AMP phosphotransferase activity
GO:0047506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)adenylate kinase activity
GO:0047506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dAMP = ADP + dADP
GO:0047506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(deoxy)adenylate kinase"
GO:0047506	skos:prefLabel	"(deoxy)adenylate kinase"
REACT:R-DME-2028651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Drosophila melanogaster)
RHEA:43843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DDI-3000383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I, HDAC7 SUMOylate PML with SUMO1 (Dictyostelium discoideum)
REACT:R-BTA-418858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoGTPase GEF's recruited to DCC (Bos taurus)
REACT:R-DDI-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)
RHEA:68607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfopropanediol <=> H(+) + hydroxyacetone + sulfite
GO:0001859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C3dg receptor activity
REACT:R-XTR-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Xenopus tropicalis)
REACT:R-DRE-1296037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with large conductance (Danio rerio)
RHEA:68952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoscopoletin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + scoparone
REACT:R-RNO-163625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon binds to Glucagon receptor (Rattus norvegicus)
RHEA:69936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(out) + Na(+)(out) => guanosine(in) + Na(+)(in)
RHEA:40898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine
REACT:R-SSC-5654607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PPTN11 (Sus scrofa)
REACT:R-MMU-5609665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
REACT:R-CFA-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Canis familiaris)
REACT:R-DRE-9700662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Danio rerio)
REACT:R-XTR-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:66481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenin + UDP-alpha-D-glucose => gypsogenin 28-beta-D-glucoside + UDP
RHEA:26309	skos:prefLabel	"1,4-dihydroxy-2-naphthoyl-CoA hydrolase"
RHEA:26309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)
RHEA:26309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,4-dihydroxy-2-naphthoyl-CoA hydrolase"
GO:0044769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
RHEA:17628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lysopine + H2O + NADP(+) <=> H(+) + L-lysine + NADPH + pyruvate
GO:0016797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters"
GO:0016797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
GO:0016797	skos:prefLabel	"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters"
RHEA:15341	skos:prefLabel	"cobaltochelatase"
RHEA:15341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobaltochelatase"
RHEA:15341	skos:altLabel	"hydrogenobyrinic acid a,c-diamide cobaltochelatase"
RHEA:15341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate
RHEA:16945	skos:altLabel	"glycine synthase"
RHEA:16945	skos:prefLabel	"aminomethyltransferase"
RHEA:16945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)
RHEA:16945	skos:altLabel	"glycine-cleavage system T-protein"
RHEA:16945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminomethyltransferase"
RHEA:16945	skos:altLabel	"tetrahydrofolate aminomethyltransferase"
REACT:R-DRE-934604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
REACT:R-CFA-8981570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)
REACT:R-DDI-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Dictyostelium discoideum)
RHEA:29744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine(in) => 2-phenylethylamine(out)
RHEA:41596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)
REACT:R-DDI-6807585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPI binds LPS on the bacterial surface (Dictyostelium discoideum)
RHEA:19848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocardicin E + S-adenosyl-L-methionine <=> H(+) + isonocardicin A + S-methyl-5'-thioadenosine
RHEA:72984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + harmol => 6-(3-dimethylallyl)harmol + diphosphate
RHEA:26181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate
REACT:R-CFA-2090038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses heparan chain(2) (Canis familiaris)
REACT:R-RNO-8857928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPIHBP1 binds HSPG:LPL dimer (Rattus norvegicus)
RHEA:16157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[leghemoglobin] + NADH = 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)
RHEA:16157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[leghemoglobin] + NADPH = 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)
RHEA:16157	skos:prefLabel	"leghemoglobin reductase"
RHEA:16157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leghemoglobin reductase"
REACT:R-DDI-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Dictyostelium discoideum)
RHEA:56701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate
REACT:R-CFA-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)
REACT:R-BTA-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)
REACT:R-DRE-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Danio rerio)
REACT:R-HSA-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)
REACT:R-CFA-170847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
REACT:R-CFA-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Canis familiaris)
RHEA:54668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-alpha-onocerin = alpha-onocerin
RHEA:54668	skos:prefLabel	"alpha-onocerin synthase"
RHEA:54668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-onocerin synthase"
RHEA:19599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-citrulline + NH4(+) => H2O + L-arginine
RHEA:13191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O
REACT:R-XTR-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Xenopus tropicalis)
REACT:R-GGA-2032770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1 to the nucleus (Gallus gallus)
RHEA:39448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)
RHEA:14876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-ethanol + NAD(+) <=> H(+) + indole-3-acetaldehyde + NADH
REACT:R-RNO-8856525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANGPTL8 binds ANGPTL3 (Rattus norvegicus)
RHEA:47307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:14320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	morphine + NAD(+) <=> H(+) + morphinone + NADH
RHEA:72970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) <=> 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)
REACT:R-SSC-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Sus scrofa)
REACT:R-DRE-8983378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Danio rerio)
REACT:R-DME-9009536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX5 binds ESR1:estrogen:TFF1 gene promoter (Drosophila melanogaster)
REACT:R-CFA-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Canis familiaris)
REACT:R-DME-5694126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C3B hydrolyses 7MGP to 7MG (Drosophila melanogaster)
REACT:R-BTA-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Bos taurus)
REACT:R-BTA-5607023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IXa associates with cell membrane (Bos taurus)
REACT:R-CEL-8866542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)
REACT:R-HSA-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Homo sapiens)
REACT:R-BTA-6801109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHM binds RGGT (Bos taurus)
RHEA:12433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine
RHEA:61776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside D + UDP-alpha-D-glucose = H(+) + rebaudioside M + UDP
REACT:R-HSA-482775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of (inferred) platelet cytosolic components (Homo sapiens)
REACT:R-HSA-350318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of vimentin at TNLD (429) (Homo sapiens)
REACT:R-SPO-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Schizosaccharomyces pombe)
RHEA:33243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-5621347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG2 translocates from cytosol to plasma membrane (Bos taurus)
RHEA:48709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
REACT:R-HSA-8870489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA4,(5,6) bind PI3P (Homo sapiens)
REACT:R-MMU-8852019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET bound PI3K generates PIP3 (Mus musculus)
RHEA:60824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate = 2 AMP + 2 H(+)
RHEA:41067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)
RHEA:32340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-thujan-3-ol + NADP(+) => (+)-thujan-3-one + H(+) + NADPH
REACT:R-XTR-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)
REACT:R-RNO-5626227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CP110 and CEP97 dissociate from the centriole (Rattus norvegicus)
GO:0009885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane histidine kinase cytokinin receptor activity
REACT:R-DDI-8854071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome-mediated degradation of PolyUb-FBXL7 (Dictyostelium discoideum)
REACT:R-CFA-1006169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds host cell surface markers (Canis familiaris)
RHEA:18983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydropantolactone + H(+) + NADPH => (R)-pantolactone + NADP(+)
REACT:R-CFA-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Canis familiaris)
RHEA:41970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E))
REACT:R-RNO-1482548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPA is acylated to PA by AGPAT5 (OM) (Rattus norvegicus)
GO:0033812	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:acetyl-CoA C-succinyltransferase activity
GO:0033812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoadipyl-CoA thiolase activity
REACT:R-RNO-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Rattus norvegicus)
RHEA:63954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + phosphate => a sphingoid 1-phosphate + H2O
REACT:R-DRE-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Danio rerio)
GO:0102747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity
REACT:R-HSA-8983011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of STAT5 upregulated genes (Homo sapiens)
REACT:R-MMU-169905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARMS is phosphorylated by active TrkA receptor (Mus musculus)
RHEA:52949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + UDP-alpha-D-glucuronate => deoxycholoyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-DME-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Drosophila melanogaster)
REACT:R-SSC-9718379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds chemical antagonists (Sus scrofa)
RHEA:46604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate
RHEA:24365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) => 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
GO:0015255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanediol channel activity
REACT:R-SPO-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Schizosaccharomyces pombe)
RHEA:63803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose <=> GDP-beta-L-gulose
REACT:R-HSA-9706364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of ubiquitinated FLT3 (Homo sapiens)
RHEA:54186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + an aromatic L-alpha-amino acid => an N-acyl-aromatic L-alpha-amino acid + H2O
RHEA:53111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-211991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclophosphamide is 4-hydroxylated by CYP2B6 (Mus musculus)
REACT:R-RNO-71020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Rattus norvegicus)
REACT:R-HSA-5244404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
REACT:R-DRE-2142859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growing HA is extruded from the cell by ABCC5 (Danio rerio)
RHEA:68528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = beta-bisabolene + diphosphate
REACT:R-BTA-2029455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIA with IgG-coated Ag (Bos taurus)
REACT:R-CEL-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-SSC-9011952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Sus scrofa)
REACT:R-SPO-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Schizosaccharomyces pombe)
RHEA:19071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + methylglyoxal => (R)-S-lactoylglutathione
GO:0001222	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcription corepressor binding
GO:0001222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription corepressor binding
REACT:R-BTA-9707505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to CLEC1B dimer (Bos taurus)
REACT:R-BTA-5252041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Bos taurus)
REACT:R-CEL-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Caenorhabditis elegans)
REACT:R-HSA-9024326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Homo sapiens)
REACT:R-RNO-2022141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolysyl oxidase activation (Rattus norvegicus)
REACT:R-HSA-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Homo sapiens)
REACT:R-CFA-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Canis familiaris)
RHEA:33867	skos:altLabel	"(S)-ureidoglycine--glyoxylate aminotransferase"
RHEA:33867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + glyoxylate = glycine + N-carbamoyl-2-oxoglycine
RHEA:33867	skos:altLabel	"UGXT"
RHEA:33867	skos:prefLabel	"(S)-ureidoglycine--glyoxylate transaminase"
RHEA:33867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-ureidoglycine--glyoxylate transaminase"
RHEA:21760	skos:prefLabel	"3-hydroxybutyryl-CoA epimerase"
RHEA:21760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybutyryl-CoA epimerase"
RHEA:21760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA
RHEA:46046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA => (3Z)-octenoyl-CoA
RHEA:62033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O => a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)
GO:0061486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity fructose transmembrane transporter activity
GO:0061486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity fructose transmembrane transporter activity
REACT:R-RNO-8855375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dissociates from CSK (Rattus norvegicus)
REACT:R-CEL-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Caenorhabditis elegans)
REACT:R-HSA-449115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
RHEA:11469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-methyl-2-oxopentanoate + L-valine => 3-methyl-2-oxobutanoate + L-isoleucine
REACT:R-HSA-5659674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)
RHEA:61061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose => a neolactoside nLc4Cer + H(+) + UDP
REACT:R-XTR-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Xenopus tropicalis)
REACT:R-DRE-977375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR1 binds C3bBb/C4bC2a (Danio rerio)
REACT:R-MMU-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Mus musculus)
REACT:R-HSA-73573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms CAP to N-carb-L-Asp (Homo sapiens)
RHEA:58445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-SSC-200652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)
RHEA:64335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + nicotinate <=> AMP + diphosphate + nicotinyl-CoA
REACT:R-DME-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Drosophila melanogaster)
RHEA:62942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + cytosine + H(+) => H2O + N(4)-acetylcytosine
REACT:R-RNO-8850777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK14 (Rattus norvegicus)
RHEA:13566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)
RHEA:72268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + formate(in) => chloride(in) + formate(out)
RHEA:41541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine
GO:0140679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type sodium transporter activity
GO:0140679	skos:prefLabel	"ABC-type Na(+) transporter"
GO:0140679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type Na(+) transporter"
RHEA:47161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carboxylate + NAD(+) => 3-dehydro-4-methylzymosterol + CO2 + NADH
RHEA:13822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + glutarate + O2 => (S)-2-hydroxyglutarate + CO2 + succinate
REACT:R-MMU-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Mus musculus)
RHEA:45507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]
REACT:R-DRE-74743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-Y427-SHC1 from insulin receptor (Danio rerio)
REACT:R-RNO-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Rattus norvegicus)
RHEA:21268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH
RHEA:21268	skos:altLabel	"(R)-canadine synthase"
RHEA:21268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"berberine reductase"
RHEA:21268	skos:prefLabel	"berberine reductase"
REACT:R-RNO-200423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Rattus norvegicus)
REACT:R-XTR-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Xenopus tropicalis)
GO:0004667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin D2 synthase activity
GO:0004667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGD2 synthase activity
GO:0004667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGH-PGD isomerase activity
GO:0004667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin-D synthase activity
GO:0004667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-R-prostaglandin D isomerase activity
GO:0004667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-H2 D-isomerase activity
GO:0004667	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity
GO:0140813	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	urate:organic anion antiporter activity
GO:0140813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urate:anion antiporter activity
REACT:R-CEL-3247844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the plasma membrane (Caenorhabditis elegans)
GO:0102862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming)
REACT:R-DME-3858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL recruits RAC (Drosophila melanogaster)
RHEA:40432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)
REACT:R-XTR-1855163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Xenopus tropicalis)
RHEA:34891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenite(in) = selenite(out)
REACT:R-DRE-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Danio rerio)
REACT:R-BTA-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)
RHEA:36271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + theobromine
GO:0003923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Homo sapiens)
GO:0003923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-anchor transamidase activity
REACT:R-MMU-429594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Mus musculus)
GO:0102846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity
REACT:R-XTR-8866277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 directly binds some endocytic cargo (Xenopus tropicalis)
REACT:R-SSC-1981157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of collagen propeptide hydroxylysines (Sus scrofa)
REACT:R-RNO-416516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRK2 sequesters activated Gq (Rattus norvegicus)
RHEA:20094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin + H(+) + UDP-alpha-D-glucose => an anthocyanidin 3-O-beta-D-glucoside + UDP
RHEA:63553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin-(1-7) + H2O => angiotensin-(1-5) + L-histidyl-L-proline
RHEA:21565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an acyl-CoA => a 3-oxoacyl-CoA + CoA
GO:0051990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-2-hydroxyglutarate dehydrogenase activity
GO:0051990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate dehydrogenase activity
RHEA:30109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomalonate semialdehyde + H(+) + NADPH => D-serine + NADP(+)
RHEA:31603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-ureidoacrylate + H2O = (Z)-3-aminoacrylate + carbamate + H(+)
REACT:R-XTR-382055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb7 binds to the active PDGF receptor (Xenopus tropicalis)
REACT:R-BTA-446862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylated IRAK1 associates with TRAF6 (Bos taurus)
RHEA:14851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + urea => H2O + N-amidino-L-aspartate
RHEA:29934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)
REACT:R-CFA-9632412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 is recruited to methylated ESR1 (Canis familiaris)
RHEA:40996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => 4-hydroxybenzaldehyde + acetyl-CoA
RHEA:57308	skos:prefLabel	"L-glutamine-phosphate cytidylyltransferase"
RHEA:57308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glutamine-phosphate cytidylyltransferase"
RHEA:57308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + N(5)-phospho-L-glutamine = diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine
REACT:R-SSC-5686359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPs translocate from extracellular region to clathrin-coated vesicle (Sus scrofa)
RHEA:61373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O => 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate
RHEA:70693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + glycine(in) + 2 Na(+)(in) => chloride(out) + glycine(out) + 2 Na(+)(out)
RHEA:62422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + CO2 + H2O => a (R)-2-hydroxy fatty acid + O2
RHEA:48393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
REACT:R-MMU-195251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the destruction complex (Mus musculus)
RHEA:56729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-all-trans-beta-carotene + AH2 + O2 => 4,4-dihydroxy-all-trans-beta-carotene + A + H2O
RHEA:49883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-6809810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Xenopus tropicalis)
REACT:R-DRE-5423672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)
REACT:R-HSA-110351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of SMUG1 glycosylase by APEX1 at the AP site (Homo sapiens)
REACT:R-BTA-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Bos taurus)
RHEA:31510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate
RHEA:42744	skos:altLabel	"ribosomal RNA large subunit methyltransferase G"
RHEA:42744	skos:prefLabel	"23S rRNA (guanine(1835)-N(2))-methyltransferase"
RHEA:42744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:42744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (guanine(1835)-N(2))-methyltransferase"
REACT:R-DRE-446195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLK phosphorylates DCHOL to DOLP (Danio rerio)
RHEA:10160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-iditol + NAD(+) = H(+) + keto-L-sorbose + NADH
RHEA:41831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexanoyl-[ACP] <=> (2E)-hexenoyl-[ACP] + H2O
RHEA:59689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltoheptaose + O2 => D-maltoheptaono-1,5-lactone + H2O2
REACT:R-DRE-171106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex => LDLR + LDL (Danio rerio)
REACT:R-HSA-9016751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 (Homo sapiens)
REACT:R-DDI-9707186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 binds ALOX5 inhibitors (Dictyostelium discoideum)
RHEA:71470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + substance P <=> L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)
REACT:R-SSC-9009558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds SDC1 (Sus scrofa)
REACT:R-XTR-8848316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36 binds IL1RL2 (Xenopus tropicalis)
GO:0008813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity
GO:0008813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate lyase activity
GO:0008813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate synthetase activity
GO:0008813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CL
GO:0008813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CPL
GO:0008813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate pyruvate lyase activity
GO:0008813	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UbiC
REACT:R-HSA-9756724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene (Homo sapiens)
RHEA:23280	skos:prefLabel	"thioethanolamine S-acetyltransferase"
RHEA:23280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thioethanolamine S-acetyltransferase"
RHEA:23280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + cysteamine = CoA + S-acetylcysteamine
RHEA:23280	skos:altLabel	"thioethanolamine acetyltransferase"
RHEA:23280	skos:altLabel	"thioltransacetylase B"
RHEA:44079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + pentadecanoate <=> AMP + diphosphate + pentadecanoyl-CoA
REACT:R-DME-443779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Linkage of L1 with treadmilling F-actin (Drosophila melanogaster)
REACT:R-SCE-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Saccharomyces cerevisiae)
REACT:R-HSA-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Homo sapiens)
REACT:R-XTR-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Xenopus tropicalis)
RHEA:68533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (Z)-alpha-bisabolene + diphosphate
REACT:R-CFA-9756138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)
REACT:R-XTR-9009308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 polyubiquitinates RUNX2 (Xenopus tropicalis)
REACT:R-XTR-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Xenopus tropicalis)
REACT:R-CFA-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Canis familiaris)
RHEA:15923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol => 2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol
REACT:R-GGA-3900047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX17 with SUMO1 (Gallus gallus)
REACT:R-HSA-9757951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
REACT:R-DDI-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Dictyostelium discoideum)
RHEA:29171	skos:altLabel	"cytochrome b561"
RHEA:29171	skos:prefLabel	"superoxide oxidase"
RHEA:29171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"superoxide oxidase"
RHEA:29171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + 2 O2 = a ubiquinone + 2 H(+) + 2 superoxide
REACT:R-XTR-352191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A8-mediated uptake of neutral amino acids (Xenopus tropicalis)
RHEA:38074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA
RHEA:16839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + AMP + 2 H(+) => 5'-acylphosphoadenosine + H2O
RHEA:22799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-hamamelose <=> ADP + D-hamamelose 2'-phosphate + H(+)
REACT:R-MMU-9659568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 transports cytosolic Cl- to extracellular region (Mus musculus)
REACT:R-RNO-982768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GH:GHR:JAK2 complex undergoes a conformational change (Rattus norvegicus)
REACT:R-RNO-9661425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL:ALB dissociates (Rattus norvegicus)
REACT:R-DME-1504190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Drosophila melanogaster)
REACT:R-HSA-4088439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXM1 binds CENPF promoter (Homo sapiens)
REACT:R-SSC-8871194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 and GAPVD1 bind AP-2 (Sus scrofa)
REACT:R-DME-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Drosophila melanogaster)
RHEA:11181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-asparagine + tRNA(Asn) => AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)
RHEA:67276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH
RHEA:67550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O
REACT:R-BTA-380073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
REACT:R-BTA-193695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK interacts with TRAF6 (Bos taurus)
RHEA:65901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + glyoxylate => glycine + H2O + xanthurenate
REACT:R-CFA-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Canis familiaris)
REACT:R-MMU-9796691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPATA2 links CYLD to LUBAC (Mus musculus)
RHEA:33385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP => (S)-malate + UDP-N-acetyl-alpha-D-glucosamine
GO:0070182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase binding
REACT:R-SSC-2161964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Sus scrofa)
RHEA:36385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + nebramycin 5' => carbamoyl adenylate + tobramycin
REACT:R-SCE-195664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Saccharomyces cerevisiae)
GO:0031816	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P2Y6 nucleotide receptor ligand
GO:0031816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y6 nucleotide receptor binding
REACT:R-SSC-265425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with von Willbrand Factor (Sus scrofa)
REACT:R-MMU-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)
REACT:R-CFA-2314686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS2 (Canis familiaris)
RHEA:54001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
RHEA:33487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA = CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine
REACT:R-BTA-1471322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins are secreted (Bos taurus)
REACT:R-MMU-9709842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS binds TOMM70 (Mus musculus)
REACT:R-SPO-425983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Schizosaccharomyces pombe)
RHEA:37608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-RNO-1855163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Rattus norvegicus)
REACT:R-HSA-8951910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds the RUNX1 promoter (Homo sapiens)
GO:0033038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bitter taste receptor activity
RHEA:38849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:46281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0016421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA carboxylase activity
REACT:R-HSA-9684336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp1-4 cleaves itself (Homo sapiens)
REACT:R-MMU-5368596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Mus musculus)
REACT:R-HSA-5678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ABCB4 does not transport PC from plasma membrane to extracellular region (Homo sapiens)
GO:0061473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	murein tripeptide carboxypeptidase activity
REACT:R-HSA-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RHEA:17226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] => 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
REACT:R-HSA-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Homo sapiens)
GO:0047393	skos:prefLabel	"glycerol-1,2-cyclic-phosphate 2-phosphodiesterase"
GO:0047393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-1,2-cyclic-phosphate 2-phosphodiesterase"
GO:0047393	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity
GO:0047393	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity
GO:0047393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H(+)
GO:0047393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity
RHEA:19884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + L-lysyl-[protein] <=> diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]
RHEA:29774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenate(in) + ATP + H2O <=> ADP + arsenate(out) + H(+) + phosphate
REACT:R-DME-450580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1 (hnRNP D0) is ubiquitinylated (Drosophila melanogaster)
REACT:R-MMU-879594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO4C1 mediates the transport of digoxin (Mus musculus)
REACT:R-XTR-804969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B1 hydrogenates E1 to EST17b (Xenopus tropicalis)
RHEA:35158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4,5-dihydroxypentane-2,3-dione <=> (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one
RHEA:24828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-MMU-2029453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of VAV (Mus musculus)
RHEA:39228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octacosenoyl-CoA + H(+) + NADPH => NADP(+) + octacosanoyl-CoA
EC:2.5.1.138	skos:prefLabel	"coumarin 8-geranyltransferase"
EC:2.5.1.138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coumarin 8-geranyltransferase"
REACT:R-HSA-2400010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT inhibitors block AKT membrane recruitment (Homo sapiens)
REACT:R-BTA-2162226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Bos taurus)
REACT:R-CFA-549297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Canis familiaris)
REACT:R-CFA-9697750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is cleaved by CASP8:FLIP(L) (Canis familiaris)
RHEA:46667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + H(+) + NADPH <=> 5beta-dihydrocorticosterone + NADP(+)
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+)-linked isocitrate dehydrogenase activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP-dependent isocitric dehydrogenase activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate dehydrogenase (NADP) activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP-dependent isocitrate dehydrogenase activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dual-cofactor-specific isocitrate dehydrogenase activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate (NADP) dehydrogenase activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate:NADP+ oxidoreductase (decarboxylating)
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP isocitric dehydrogenase activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate dehydrogenase (NADP+) activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate dehydrogenase (NADP-dependent) activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP(+)-IDH activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADP(+)-ICDH activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP-specific isocitrate dehydrogenase activity
GO:0004450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP-linked isocitrate dehydrogenase activity
REACT:R-CEL-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Caenorhabditis elegans)
RHEA:56471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O
REACT:R-CFA-8875482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin to ubiquitinated MET (Canis familiaris)
RHEA:38147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbon disulfide + H2O = carbonyl sulfide + H(+) + hydrogen sulfide
RHEA:45115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol + H(+) + NADPH + O2 <=> 13-hydroxy-gamma-tocopherol + H2O + NADP(+)
REACT:R-DRE-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Danio rerio)
REACT:R-HSA-1222512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric oxide oxidizes to nitrosyl ion (Homo sapiens)
RHEA:14615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + taurine(in) => ATP + H2O + taurine(out)
REACT:R-DRE-4224014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by ADAM10, ADAM15 (Danio rerio)
RHEA:14125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"raffinose--raffinose alpha-galactosyltransferase"
RHEA:14125	skos:prefLabel	"raffinose--raffinose alpha-galactosyltransferase"
RHEA:14125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 raffinose = 1(F)-alpha-D-galactosylraffinose + sucrose
REACT:R-CFA-9021600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-proteins dissociate from plasma-membrane estrogen receptors (Canis familiaris)
REACT:R-SSC-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Sus scrofa)
RHEA:16319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indan-1-one + NADH => (S)-indan-1-ol + NAD(+)
REACT:R-HSA-209924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is decarboxylated to dopamine (Homo sapiens)
REACT:R-HSA-163217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
GO:0033294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ectoine binding
REACT:R-DRE-5632649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Npp binds GAS1 and PTCH (Danio rerio)
REACT:R-DME-71241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Drosophila melanogaster)
GO:0034867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,4-trimethylpent-2-enoyl-CoA hydratase activity
REACT:R-CFA-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Canis familiaris)
RHEA:26167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + echinenone + O2 <=> 4'-hydroxyechinenone + A + H2O
RHEA:42936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Sus scrofa)
REACT:R-SCE-6798739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule membrane proteins (Saccharomyces cerevisiae)
REACT:R-SSC-8852337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds TP53 (Sus scrofa)
RHEA:62702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol => H2O + naphtopyrone YWA1
RHEA:44160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 6-phosphate + H2O = myo-inositol + phosphate
REACT:R-RNO-193719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Rattus norvegicus)
REACT:R-SSC-983194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-1 is a heterotetramer (Sus scrofa)
REACT:R-DRE-9762096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub,pS335,S338,T NFE2L2 is degraded (Danio rerio)
REACT:R-HSA-190326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 (Homo sapiens)
RHEA:47121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoate + glycine => H2O + N-docosanoylglycine
RHEA:42188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH
REACT:R-SSC-2395328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTBP1, LTBP3 bind TGF-Beta (Sus scrofa)
EC:1.9.98.-	skos:prefLabel	"With other, known, acceptors"
EC:1.9.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
REACT:R-DME-141429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of APC/C via CDC20 sequestration (Drosophila melanogaster)
RHEA:25827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermine <=> H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine
RHEA:53607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycerol + phosphate
GO:0005352	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	general alpha-glucoside transporter activity
GO:0005352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	general alpha-glucoside:proton symporter activity
GO:0005352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	general alpha-glucoside:hydrogen symporter activity
GO:0005352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-glucoside:proton symporter activity
GO:0005352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-glucoside:hydrogen symporter activity
GO:0102884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-zingiberene synthase activity
RHEA:46534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-SSC-352103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Sus scrofa)
RHEA:23514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 1-phosphate + D-glucose => alpha,alpha-trehalose + phosphate
REACT:R-MMU-1799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)
RHEA:15462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-DME-351876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of occludin (Drosophila melanogaster)
RHEA:15778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O => 1-guanidino-1-deoxy-scyllo-inositol + phosphate
REACT:R-CEL-5661116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me3K5-histone H3 (Caenorhabditis elegans)
REACT:R-DRE-195664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)
REACT:R-XTR-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Xenopus tropicalis)
REACT:R-HSA-9636247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPE2:KPNA1:KPNB1 translocates to the nucleus (Homo sapiens)
RHEA:45200	skos:prefLabel	"5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase"
RHEA:45200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)
RHEA:45200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase"
REACT:R-DRE-1793182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Danio rerio)
REACT:R-HSA-8856157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAG3 (CD233) binds MHC II (Homo sapiens)
RHEA:22926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + NH4(+) => dCMP + H(+) + H2O
RHEA:31731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase"
RHEA:31731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O
RHEA:31731	skos:prefLabel	"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase"
RHEA:46458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH
REACT:R-CEL-1482867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLCL is acylated to MLCL by LCLAT1 (ER) (Caenorhabditis elegans)
RHEA:60466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)
REACT:R-XTR-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Xenopus tropicalis)
REACT:R-RNO-400092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Rattus norvegicus)
REACT:R-DDI-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Dictyostelium discoideum)
REACT:R-DME-9624876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP recruits nuclear envelope (NE) membranes (Drosophila melanogaster)
REACT:R-BTA-2064406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Bos taurus)
REACT:R-BTA-877269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)
REACT:R-DME-163756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of fatty acid synthase (FAS) dimer (Drosophila melanogaster)
RHEA:58976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + malonaldehyde + O2 = 3-oxopropanoate + H(+) + H2O2
RHEA:56397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)
REACT:R-HSA-9694681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA5 is translated to protein M (Homo sapiens)
REACT:R-CFA-191072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of Cx43 (Canis familiaris)
REACT:R-MMU-2395869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
REACT:R-SSC-8953917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Sus scrofa)
RHEA:52602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-propanoyl-L-methioninate => L-methionine + propanoyl-CoA
REACT:R-HSA-9756136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV (Homo sapiens)
RHEA:27683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dTDP => ADP + dTTP
GO:0015345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric enterobactin:proton symporter activity
GO:0015345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric-enterobactin:proton symporter activity
GO:0015345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric enterobactin:hydrogen symporter activity
REACT:R-HSA-9612085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
RHEA:41091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine
REACT:R-DME-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Drosophila melanogaster)
REACT:R-SCE-1222516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intraphagosomal pH is lowered to 5 by V-ATPase (Saccharomyces cerevisiae)
REACT:R-DDI-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Dictyostelium discoideum)
REACT:R-CFA-5357928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)
REACT:R-CFA-904864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Canis familiaris)
RHEA:28626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol
REACT:R-RNO-163733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of FAS monomer gene by ChREBP:MLX (Rattus norvegicus)
GO:0016699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With an iron-sulfur protein as acceptor"
GO:0016699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor
GO:0016699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GO:0016699	skos:prefLabel	"With an iron-sulfur protein as acceptor"
RHEA:38746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol
REACT:R-SSC-4085033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Sus scrofa)
REACT:R-MMU-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)
RHEA:51059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + androst-4-ene-3,17-dione <=> AH2 + androsta-1,4-diene-3,17-dione
REACT:R-SSC-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Sus scrofa)
REACT:R-CFA-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Canis familiaris)
RHEA:28966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-proline(out) <=> H(+)(in) + L-proline(in)
REACT:R-DRE-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Danio rerio)
REACT:R-DME-75079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC C complex (Drosophila melanogaster)
RHEA:20721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + isopenicillin N + phenylacetyl-CoA => CoA + H(+) + L-2-aminoadipate + penicillin G
REACT:R-HSA-1791069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ACADVL (Homo sapiens)
REACT:R-XTR-9705713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A2 dehydrogenates TEST to DHTEST (Xenopus tropicalis)
REACT:R-MMU-74718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalisation of the insulin receptor (Mus musculus)
REACT:R-BTA-5685602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCR3LG1 binds NCR3 (Bos taurus)
REACT:R-DRE-8955245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Danio rerio)
REACT:R-HSA-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)
REACT:R-HSA-9619355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKK autophosphorylates in the cytosol (Homo sapiens)
REACT:R-RNO-5627802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A4 transports I- from cytosol to extracellular region (Rattus norvegicus)
REACT:R-CFA-9668904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18 complex (Canis familiaris)
RHEA:48383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)
REACT:R-DME-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)
REACT:R-MMU-917987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFRC dimer binds 2xholoTF (Mus musculus)
RHEA:54994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+) => 3 A + FMN + H2O + L-glutamate + O2
REACT:R-BTA-4615872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO1 (Bos taurus)
RHEA:47739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-391937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP/CysLT receptor can bind cysteinyl leukotrienes (Caenorhabditis elegans)
REACT:R-CFA-688136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)
RHEA:21150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose
REACT:R-GGA-201677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Gallus gallus)
REACT:R-HSA-3323079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
GO:0050454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	F420-reducing hydrogenase activity
GO:0050454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	8-hydroxy-5-deazaflavin-reducing hydrogenase activity
GO:0050454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:coenzyme F420 oxidoreductase activity
GO:0050454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coenzyme F420-dependent hydrogenase activity
GO:0050454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420 hydrogenase activity
RHEA:47073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-eicosanoylglycerol + H2O => eicosanoate + glycerol + H(+)
REACT:R-CFA-8933328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYPLA2 hydrolyses PALM-C3,4-GAP43 (Canis familiaris)
RHEA:55671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol--[retinol-binding protein] + NAD(+) <=> 11-cis-retinal--[retinol-binding protein] + H(+) + NADH
REACT:R-GGA-5218832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds PAK2 (Gallus gallus)
REACT:R-CEL-9617370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-antagonists bind ADRA1A,B,D (Caenorhabditis elegans)
REACT:R-DRE-4608855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRICKLE1 is degraded by the proteasome (Danio rerio)
REACT:R-HSA-77301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Homo sapiens)
RHEA:23955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(2-phenylethyl)acetamide <=> 2-phenylethylamine + acetate
RHEA:44212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxytetradecanoate + ATP + CoA = 3-hydroxytetradecanoyl-CoA + AMP + diphosphate
REACT:R-SSC-434989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA7A binds to PLXNC1 (Sus scrofa)
RHEA:40361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP
REACT:R-CFA-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Canis familiaris)
GO:0102410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin-4',3-O-glucosyltransferase activity
RHEA:21211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-serine <=> L-serine + phosphate
GO:0008454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminyltransferase IV activity
GO:0008454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity
GO:0008454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity
GO:0008454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GnTIV activity
GO:0008454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity
GO:0008454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV
GO:0008454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-acetylglucosaminyltransferase IV activity
GO:0008454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0008454	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0008454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity
REACT:R-GGA-420489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parathyroid hormone receptor can bind parathyroid hormone (Gallus gallus)
REACT:R-HSA-1482689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)
REACT:R-MMU-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Mus musculus)
REACT:R-CFA-5682992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A,B bind H4K20Me2 (Canis familiaris)
REACT:R-CEL-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Caenorhabditis elegans)
REACT:R-MMU-68615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-6) complex (Mus musculus)
REACT:R-SSC-175987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from AdoMet to PY (Sus scrofa)
REACT:R-HSA-8950201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Aryl Hydrocarbon receptor-interacting protein (Homo sapiens)
REACT:R-SPO-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Schizosaccharomyces pombe)
REACT:R-HSA-9661726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An unknown reductase reduces D-UBGN to STBN (Homo sapiens)
RHEA:45501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]
GO:0008506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose:hydrogen symporter activity
GO:0008506	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogen/sucrose transporter activity
GO:0008506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose:proton symporter activity
RHEA:62291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate <=> (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate
REACT:R-GGA-449715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Gallus gallus)
RHEA:20355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + tetrachloroethene => A + chloride + H(+) + trichloroethene
RHEA:19519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylamine + formate => H2O + N,N-dimethylformamide
RHEA:35309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate
GO:0015528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose:hydrogen symporter activity
GO:0015528	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lactose, galactose:hydrogen symporter activity
GO:0015528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose:proton symporter activity
REACT:R-HSA-9645481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIFA oligomerization (Homo sapiens)
REACT:R-MMU-8852809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPN, CPB2 cleave C3a, C5a (Mus musculus)
REACT:R-CFA-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Canis familiaris)
REACT:R-HSA-205234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of GAB2 to p-KIT (Homo sapiens)
RHEA:56241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]
REACT:R-RNO-1675939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Rattus norvegicus)
REACT:R-CFA-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Canis familiaris)
REACT:R-DDI-170674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the Gi alpha:G olf complex (Dictyostelium discoideum)
REACT:R-SPO-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
REACT:R-SPO-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Schizosaccharomyces pombe)
RHEA:17522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) => ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate
RHEA:40484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)
RHEA:58069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + trans-isoeugenol => acetaldehyde + vanillin
RHEA:69228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-N-(sulfonatooxy)alkenimidothioate = an epithionitrile + sulfate
RHEA:67678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-DRE-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Danio rerio)
REACT:R-RNO-77314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Rattus norvegicus)
RHEA:36047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glyceraldehyde dehydrogenase (FAD-containing)"
RHEA:36047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H(+)
RHEA:36047	skos:prefLabel	"glyceraldehyde dehydrogenase (FAD-containing)"
RHEA:36047	skos:altLabel	"glyceraldehyde oxidoreductase"
RHEA:35542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 <=> albonoursin + H2O2
REACT:R-CFA-5682709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI4 binds ADAM22,23,11 (Canis familiaris)
RHEA:42768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2S)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH
REACT:R-BTA-417820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y9 receptor can bind to LPA (Bos taurus)
RHEA:68315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O <=> 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate
GO:0004438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity
GO:0004438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol 1,3-bisphosphate phosphatase activity
GO:0004438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity
GO:0004438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol-polyphosphate 3-phosphatase activity
GO:0004438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3-phosphate phosphatase activity
GO:0004438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidyl-3-phosphate 3-phosphohydrolase activity
GO:0004438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3-phosphatase activity
GO:0004438	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol-1,3-bisphosphate 3-phosphatase activity
RHEA:28570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-serine = diphosphate + L-seryl-5'-AMP
RHEA:66464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol + H2O = scalarane-17alpha-19-diol
REACT:R-CFA-5685902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Canis familiaris)
GO:0050068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine carbamoyltransferase activity
GO:0050068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine transcarbamylase activity
GO:0050068	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate:L-lysine carbamoyltransferase activity
REACT:R-XTR-186778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 binds to the active receptor (Xenopus tropicalis)
REACT:R-HSA-9677929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOB inhibitors bind MAOB:FAD (Homo sapiens)
REACT:R-DDI-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Dictyostelium discoideum)
RHEA:31377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1H-pyrrole + CO2 => H(+) + pyrrole-2-carboxylate
REACT:R-HSA-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Homo sapiens)
GO:0072547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tricoumaroyl spermidine meta-hydroxylase activity
GO:0072547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tricoumaroylspermidine meta-hydroxylase activity
REACT:R-SCE-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Saccharomyces cerevisiae)
REACT:R-XTR-212356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL-NICD coactivator complex (Xenopus tropicalis)
REACT:R-MMU-5686704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates DCLRE1C (Mus musculus)
REACT:R-MMU-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)
REACT:R-SSC-1247668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A binds O2, releasing H+ and CO2 (Sus scrofa)
RHEA:12522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + NH4(+) => L-dopa
RHEA:51040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate imine dimer = chromopyrrolate + H(+) + NH4(+)
REACT:R-CEL-77321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Caenorhabditis elegans)
REACT:R-HSA-426209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG activation of TRPC channels (Homo sapiens)
RHEA:24275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 <=> H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)
REACT:R-BTA-9023626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Bos taurus)
RHEA:40381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP
RHEA:31623	skos:prefLabel	"L-olivosyl-oleandolide 3-O-methyltransferase"
RHEA:31623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-olivosyl-oleandolide 3-O-methyltransferase"
RHEA:31623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-olivosyl-oleandolide + S-adenosyl-L-methionine = H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine
REACT:R-DME-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Drosophila melanogaster)
RHEA:24683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydromethanopterin + NADP(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH
REACT:R-HSA-5632671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 binds SMO dimer (Homo sapiens)
REACT:R-MMU-5696914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP28 deubiquitinates CLSPN and MYC (Mus musculus)
REACT:R-GGA-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Gallus gallus)
RHEA:22188	skos:altLabel	"D-2-haloacid dehalogenase"
RHEA:22188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-haloacid dehalogenase (configuration-inverting)"
RHEA:22188	skos:altLabel	"DL-2-haloacid halidohydrolase (inversion of configuration)"
RHEA:22188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-2-haloacid dehalogenase"
RHEA:22188	skos:altLabel	"2-haloalkanoid acid halidohydrolase"
RHEA:22188	skos:altLabel	"DL-2-haloacid dehalogenase (inversion of configuration)"
RHEA:22188	skos:prefLabel	"2-haloacid dehalogenase (configuration-inverting)"
RHEA:22188	skos:prefLabel	"(R)-2-haloacid dehalogenase"
RHEA:22188	skos:altLabel	"2-haloalkanoic acid dehalogenase"
RHEA:22188	skos:altLabel	"DL-2-haloacid dehalogenase"
RHEA:22188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)
RHEA:22188	skos:altLabel	"D-DEX"
RHEA:22188	skos:altLabel	"DL-DEXi"
RHEA:21322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + keto-L-sorbose => A + D-sorbitol
REACT:R-HSA-6783332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region (Homo sapiens)
REACT:R-SPO-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Schizosaccharomyces pombe)
RHEA:64012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine = A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine
REACT:R-BTA-5666129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP recruits DIAPH2-2 to kinetochores (Bos taurus)
REACT:R-HSA-3772441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sFRP binds WNT3A and inhibits WNT:FZD binding (Homo sapiens)
REACT:R-HSA-9638076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from small HA fragments (Homo sapiens)
GO:0045322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	unmethylated CpG binding
RHEA:56383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O
RHEA:37079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine
GO:0033284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled carboxylic acid transmembrane transporter activity
GO:0033284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent carboxylic acid transporter activity
GO:0033284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxylic acid-transporting ATPase activity
REACT:R-SPO-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Schizosaccharomyces pombe)
REACT:R-RNO-442317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP6 and ZIP14 mediate zinc influx into cells (Rattus norvegicus)
REACT:R-BTA-176609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + PAPS => cholesterol sulfate + PAP (Bos taurus)
REACT:R-RNO-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Rattus norvegicus)
RHEA:52618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+) => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP
REACT:R-GGA-5676607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sBAFF,sAPRIL binds TACI,BCMA (Gallus gallus)
RHEA:56916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH
REACT:R-CFA-3928628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
REACT:R-RNO-9026005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Rattus norvegicus)
RHEA:61400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-ribulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine
GO:0038132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuregulin binding
REACT:R-GGA-112037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of PLC beta (Gallus gallus)
RHEA:48196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA
RHEA:43645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + tetradecanoyl-CoA => 3-oxohexadecanoyl-[ACP] + CO2 + CoA
GO:0070186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	growth hormone activity
GO:0070186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GH activity
GO:0070186	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	placental growth hormone activity
GO:0070186	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pituitary growth hormone activity
REACT:R-RNO-266089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Discoidal HDL binds membrane-associated free cholesterol (Rattus norvegicus)
RHEA:66515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DME-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Drosophila melanogaster)
REACT:R-XTR-2213244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of antigenic peptides (Xenopus tropicalis)
RHEA:36363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH = (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)
RHEA:18534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-L-tryptophan + H(+) => CO2 + serotonin
REACT:R-MMU-8952419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs ubiquitinate RUNX3 (Mus musculus)
REACT:R-HSA-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Homo sapiens)
REACT:R-SCE-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Saccharomyces cerevisiae)
RHEA:24932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteine => H(+) + hydrogen sulfide + NH4(+) + pyruvate
RHEA:24826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-RNO-3249372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407,Y641-STAT6 is dimerized (Rattus norvegicus)
REACT:R-RNO-421836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Derived Vesicle Uncoating (Rattus norvegicus)
REACT:R-CFA-140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequestered tissue factor -> tissue factor (Canis familiaris)
RHEA:39565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH
REACT:R-SCE-200740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Saccharomyces cerevisiae)
REACT:R-SSC-8982645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRKs bind ADRB2:Catecholamine (Sus scrofa)
REACT:R-SSC-8939201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR dimerizes (Sus scrofa)
RHEA:70313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol
REACT:R-GGA-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Gallus gallus)
GO:0102882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-acoradiene synthase activity
REACT:R-SCE-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Saccharomyces cerevisiae)
RHEA:43454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexanoyl-CoA + 2 malonyl-CoA
REACT:R-BTA-5693580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD52 with the RPA complex at resected DNA DSBs (Bos taurus)
REACT:R-HSA-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Homo sapiens)
RHEA:22811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate + H2O + O2 <=> 2,6-dihydroxynicotinate + H2O2
RHEA:68694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate)
GO:0033425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAT codon-amino acid adaptor activity
GO:0033425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAU codon-amino acid adaptor activity
GO:0033425	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histidine tRNA
REACT:R-DRE-190408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2b (Danio rerio)
REACT:R-CFA-9731393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA, EDNRB bind non-selective ERAs (Canis familiaris)
RHEA:57783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-4-nitrotoluene + NADH + O2 <=> 3-chloro-4-methylcatechol + NAD(+) + nitrite
REACT:R-DDI-195690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Dictyostelium discoideum)
RHEA:10700	skos:prefLabel	"limonene-1,2-epoxide hydrolase"
RHEA:10700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"limonene-1,2-epoxide hydrolase"
RHEA:10700	skos:altLabel	"limonene oxide hydrolase"
RHEA:10700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + limonene 1,2-epoxide = limonene-1,2-diol
REACT:R-MMU-190263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3b binds to FGF (Mus musculus)
REACT:R-MMU-204169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP dephosphorylates p-lipo-PDH (Mus musculus)
RHEA:57358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + hapalindole G + succinate => 2-oxoglutarate + chloride + H(+) + hapalindole U + O2
REACT:R-PFA-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Plasmodium falciparum)
REACT:R-RNO-166869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MEKK1 (Rattus norvegicus)
REACT:R-MMU-76054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Mus musculus)
REACT:R-CFA-5340124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSN polymer binds CaPO4 (Canis familiaris)
RHEA:66227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-C9-CoA + O2 <=> asc-DeltaC9-CoA + H2O2
REACT:R-RNO-350186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN binds GC:25(OH)D (Rattus norvegicus)
RHEA:58875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Homo sapiens)
RHEA:12948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxybiphenyl-2-sulfinate + H2O <=> biphenyl-2-ol + H(+) + sulfite
RHEA:23235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome c] + hydrazine <=> 4 Fe(II)-[cytochrome c] + 4 H(+) + N2
GO:0140907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavin-dependent halogenase activity
RHEA:22321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 alpha-D-glucose 1-phosphate + H2O => D-maltose + 2 phosphate
REACT:R-DME-6813740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDE1 hydrolyzes GroPIns (Drosophila melanogaster)
EC:1.10.3.15	skos:prefLabel	"grixazone synthase"
EC:1.10.3.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"grixazone synthase"
RHEA:32657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a coniferyl ester + NADPH => a carboxylate + eugenol + NADP(+)
REACT:R-BTA-177942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EGF ligand (Bos taurus)
RHEA:67965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylamino-L-phenylalanine + S-adenosyl-L-methionine => 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-450173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 induces oligomerisation of TRAF6 (Danio rerio)
RHEA:56971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCTP + pyruvate <=> dCDP + H(+) + phosphoenolpyruvate
RHEA:30517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-methyl-5'-thioadenosine + thermospermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine
REACT:R-CFA-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Canis familiaris)
REACT:R-HSA-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Homo sapiens)
REACT:R-RNO-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Rattus norvegicus)
RHEA:62177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-glucose + H2O => alpha-D-glucose 1-phosphate + GMP + 2 H(+)
REACT:R-DRE-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Danio rerio)
REACT:R-DDI-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Dictyostelium discoideum)
REACT:R-GGA-177941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:GAB1 binds to phosphorylated EGFR (Gallus gallus)
REACT:R-XTR-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)
RHEA:15290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose => [(1->4)-beta-D-xylan](n+1) + H(+) + UDP
RHEA:55231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-RNO-420591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-2:Nectin 3 trans heterodimer interaction (Rattus norvegicus)
RHEA:56605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-DME-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Drosophila melanogaster)
REACT:R-DME-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Drosophila melanogaster)
REACT:R-CEL-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
RHEA:19990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-alpha-D-ribose 1-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate
RHEA:26094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)
REACT:R-SSC-8948015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Sus scrofa)
REACT:R-HSA-4411367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene (Homo sapiens)
REACT:R-HSA-2990882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates NUP98 (Homo sapiens)
RHEA:21114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose => globoside Gb3Cer (d18:1(4E)) + H2O
REACT:R-HSA-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Homo sapiens)
RHEA:46297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:64866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + IDP + phosphoenolpyruvate => ITP + oxaloacetate
REACT:R-SPO-1483081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Schizosaccharomyces pombe)
GO:0034873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioacetamide S-oxygenase activity
REACT:R-RNO-5682010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10:ATG12 binds ATG5 (Rattus norvegicus)
RHEA:47919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-hexanoyl-(4R)-hydroxysphinganine <=> ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate
REACT:R-HSA-9025995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Homo sapiens)
REACT:R-DDI-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Dictyostelium discoideum)
REACT:R-XTR-5675194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPK phosphorylates RAF1 (Xenopus tropicalis)
REACT:R-GGA-163214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)
REACT:R-CFA-390425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAR1 reduces PalmCoA to HXOL (Canis familiaris)
GO:0051009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetylhomoserine sulfhydrylase activity
REACT:R-RNO-6814682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of early-endosome derived vesicles at the TGN (Rattus norvegicus)
REACT:R-RNO-2984226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NEK9 (Rattus norvegicus)
GO:0045543	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gibberellin 2-beta-hydroxylase activity
GO:0045543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin 2-beta-dioxygenase activity
GO:0045543	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gibberellin 2beta-hydroxylase activity
GO:0045543	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	(gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)
GO:0045543	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gibberellin 2beta-dioxygenase activity
GO:0045543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin 2-oxidase activity
RHEA:58235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]
RHEA:60617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine => ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate
REACT:R-DDI-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Dictyostelium discoideum)
GO:0140827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zinc chaperone activity
RHEA:39006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-HSA-8937177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:TCDD binds ARNT (Homo sapiens)
REACT:R-XTR-5610725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TULP3 is required for GPR161 localization in the cilium (Xenopus tropicalis)
REACT:R-SSC-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Sus scrofa)
RHEA:14732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
REACT:R-CFA-427528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Canis familiaris)
GO:0102660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity
RHEA:55951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-alanine + H2O <=> AH2 + NH4(+) + pyruvate
REACT:R-HSA-9727300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9b homodimer localizes to the mitochondrial outer membrane (Homo sapiens)
RHEA:66760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + kainate(in) = ADP + H(+) + kainate(out) + phosphate
RHEA:32733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + a monoacylglycerol + H(+) => a diacylglycerol + H2O
REACT:R-GGA-9710963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1dimer:KPNA1 binds KPNB1 (Gallus gallus)
REACT:R-HSA-202111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates eNOS (Homo sapiens)
RHEA:32487	skos:altLabel	"ADPRibase-Mn"
RHEA:32487	skos:altLabel	"Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase"
RHEA:32487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-choline + H2O = CMP + 2 H(+) + phosphocholine
RHEA:32487	skos:prefLabel	"Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase"
RHEA:32487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase"
REACT:R-CEL-8875576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK,CRKL recruits RAC1 GEF to activated MET (Caenorhabditis elegans)
REACT:R-DME-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
RHEA:56938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone => 17beta-hydroxy-androst-5-en-3-one
RHEA:46689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oyl-CoA + A => 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2
RHEA:57970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Danio rerio)
REACT:R-XTR-418918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The UDP/CysLT (P2Y17) receptor can bind UTP (Xenopus tropicalis)
RHEA:17252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(2+) + 2 H2O + H2O2 <=> 6 H(+) + 2 iron(III) oxide-hydroxide
REACT:R-CFA-8955010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRTOMT transfers Met to DA, forming 3MT (Canis familiaris)
RHEA:57574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:23770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + CoA + H(+) => a fatty acyl-CoA + sphing-4-enine
RHEA:24400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UMP = ADP + UDP
REACT:R-GGA-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Gallus gallus)
REACT:R-CFA-8953461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Canis familiaris)
REACT:R-MMU-2002401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Mus musculus)
RHEA:28824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-galactonate(in) => H(+)(out) + L-galactonate(out)
REACT:R-RNO-8987063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Rattus norvegicus)
REACT:R-HSA-176702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Processive Complex and Completed Telomere End (Homo sapiens)
REACT:R-MMU-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Mus musculus)
REACT:R-SCE-8867344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OMA1 hydrolyses OPA1 (Saccharomyces cerevisiae)
REACT:R-SPO-6811422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE at the ER (Schizosaccharomyces pombe)
RHEA:31622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate
RHEA:11436	skos:altLabel	"cytochrome bb3"
RHEA:11436	skos:prefLabel	"cytochrome-c oxidase"
RHEA:11436	skos:altLabel	"cytochrome cbb3"
RHEA:11436	skos:altLabel	"cytochrome ba3"
RHEA:11436	skos:altLabel	"Warburg's respiratory enzyme"
RHEA:11436	skos:altLabel	"cytochrome caa3"
RHEA:11436	skos:altLabel	"complex IV (mitochondrial electron transport)"
RHEA:11436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytochrome-c oxidase"
RHEA:11436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O
RHEA:11436	skos:altLabel	"cytochrome a3"
RHEA:11436	skos:altLabel	"cytochrome oxidase"
RHEA:11436	skos:altLabel	"cytochrome aa3"
REACT:R-HSA-9694689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
RHEA:40895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine
RHEA:25665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> alpha-pinene + diphosphate
RHEA:32983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol
REACT:R-CFA-8987120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IFNLR1 (Canis familiaris)
REACT:R-BTA-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Bos taurus)
REACT:R-CEL-9733973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts bind FABP6 (Caenorhabditis elegans)
RHEA:70835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-glutamine(out) + Na(+)(out) = L-arginine(out) + L-glutamine(in) + Na(+)(in)
RHEA:60629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + gluconapin + O2 => A + H2O + progoitrin
REACT:R-XTR-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Xenopus tropicalis)
REACT:R-DME-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Drosophila melanogaster)
REACT:R-DRE-2545203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cleaved cohesin (Danio rerio)
RHEA:25715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:32682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O <=> (2E)-geraniol + diphosphate
RHEA:11419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-O-galloyl-beta-D-glucose <=> 1,6-bis-O-galloyl-beta-D-glucose + D-glucose
REACT:R-CFA-418456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP is degraded by PDEs (Canis familiaris)
REACT:R-DRE-6783177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates GATA3,IL33 (Danio rerio)
REACT:R-HSA-9008433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds CDKN1A gene promoter (Homo sapiens)
REACT:R-DME-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Drosophila melanogaster)
RHEA:37904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxytryprostatin B + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tryprostatin A
RHEA:35571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9615015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO6 binds PLXNA4 gene (Homo sapiens)
REACT:R-XTR-9020251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Xenopus tropicalis)
REACT:R-DDI-381087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of PERK (Dictyostelium discoideum)
REACT:R-RNO-450474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates BRF1 (Rattus norvegicus)
REACT:R-DRE-1605825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT-MMPs are sorted to the plasma membrane (Danio rerio)
REACT:R-HSA-3928584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)
RHEA:67401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => allo-aromadendrene + diphosphate
REACT:R-BTA-196964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFK:Mg2+ phosphorylates RIB (Bos taurus)
REACT:R-HSA-914012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Homo sapiens)
REACT:R-DRE-9676160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds NOD2 (Danio rerio)
REACT:R-DRE-2076611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS3STs sulfate GlcN at C3 in heparan sulfate (Danio rerio)
REACT:R-GGA-354087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2 to p-PTK2 (Gallus gallus)
REACT:R-RNO-174427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Rattus norvegicus)
RHEA:36863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O
RHEA:70529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + NAD(+) => H(+) + N-acyl-3-oxosphinganine + NADH
RHEA:42211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 <=> a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)
RHEA:64178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-tryptophan => H2O + N-(9Z-octadecenoyl)-L-tryptophan
RHEA:15792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylose + NADP(+) <=> H(+) + L-xylono-1,4-lactone + NADPH
REACT:R-CEL-2142859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growing HA is extruded from the cell by ABCC5 (Caenorhabditis elegans)
REACT:R-RNO-390250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Rattus norvegicus)
GO:0045519	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-23
GO:0045519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-23 receptor binding
GO:0045519	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-23 receptor ligand
RHEA:37348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + ATP + D-alanine => ADP + D-alanyl-(R)-lactate + phosphate
REACT:R-HSA-176494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULTs transfer (SO4)2- group to 27HCHOL (Homo sapiens)
REACT:R-BTA-70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Bos taurus)
REACT:R-MMU-2247512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Mus musculus)
REACT:R-DME-9755044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP trimer transforms RBV to T-CONH2 (Drosophila melanogaster)
EC:3.4.22.38	skos:altLabel	"cathepsin O"
EC:3.4.22.38	skos:prefLabel	"cathepsin K"
EC:3.4.22.38	skos:altLabel	"cathepsin O2"
EC:3.4.22.38	skos:altLabel	"cathepsin X"
EC:3.4.22.38	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin K"
REACT:R-SSC-9023840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HATs and coactivators are recruited to the CTSD gene (Sus scrofa)
REACT:R-MMU-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Mus musculus)
RHEA:29626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltopentaose + beta-maltose <=> alpha-maltohexaose + beta-D-glucose
REACT:R-CFA-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Canis familiaris)
RHEA:11341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + H(+) => 4-guanidinobutanal + CO2
RHEA:32146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) <=> L-arginine(out)
REACT:R-CFA-9667456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AVPR1A,B bind desmopressin (Canis familiaris)
RHEA:57315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine <=> cytidine 5'-diphosphoramidate + H(+) + L-glutamate
REACT:R-BTA-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Bos taurus)
RHEA:56693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate
REACT:R-XTR-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)
RHEA:32906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0032034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin II head/neck binding
RHEA:71044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine(in) + L-phenylalanine(out) => L-alanine(out) + L-phenylalanine(in)
REACT:R-HSA-8964482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DREAM complex binds the E2F1 gene promoter (Homo sapiens)
EC:1.11.1.13	skos:altLabel	"Mn-dependent peroxidase"
EC:1.11.1.13	skos:prefLabel	"manganese peroxidase"
EC:1.11.1.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"manganese peroxidase"
REACT:R-SPO-6814119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRiC/CCT binds unfolded G-protein beta subunit (Schizosaccharomyces pombe)
RHEA:52358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate => 3'-phosphoadenylyl sulfate + pregnenolone
GO:0008892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanine aminohydrolase activity
GO:0008892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanine aminase activity
GO:0008892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GAH activity
GO:0008892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine deaminase activity
GO:0008892	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanase activity
RHEA:48944	skos:prefLabel	"chlorophyllide a reductase"
RHEA:48944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chlorophyllide a reductase"
RHEA:48944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:57977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside C-K + H(+) + UDP
REACT:R-BTA-187934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Bos taurus)
RHEA:32572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylgeranyl diphosphate + H2O => 2-methylisoborneol + diphosphate
REACT:R-DME-450463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Drosophila melanogaster)
REACT:R-PFA-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Plasmodium falciparum)
REACT:R-SPO-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Schizosaccharomyces pombe)
REACT:R-MMU-1878002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XYLTs transfer Xyl to core protein (Mus musculus)
RHEA:12780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-4-hydroxypteridine + O2 <=> 2-amino-4,7-dihydroxypteridine + chemical entity
REACT:R-XTR-8873923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 binds LPCAT1 and PC (Xenopus tropicalis)
REACT:R-XTR-5323526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRAT proteins bind GSK3beta (Xenopus tropicalis)
REACT:R-CEL-1602368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Caenorhabditis elegans)
REACT:R-CFA-177943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to EGF:EGFR complex (Canis familiaris)
REACT:R-CFA-202165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)
RHEA:21223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa + O2 <=> 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)
REACT:R-GGA-183036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL:GRB2) (Gallus gallus)
RHEA:28477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucarate(in) + H(+)(in) <=> D-glucarate(out) + H(+)(out)
REACT:R-RNO-1592436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP9 by MMPs (Rattus norvegicus)
REACT:R-SSC-1475032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Sus scrofa)
REACT:R-DME-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
REACT:R-SPO-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Schizosaccharomyces pombe)
RHEA:16570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[collagen] + O2 => (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate
RHEA:44403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-6 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-6
REACT:R-HSA-8981931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK2 (Homo sapiens)
REACT:R-DME-6788556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to NDUFV1, V2 (Drosophila melanogaster)
RHEA:46721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O
REACT:R-SPO-3968414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Schizosaccharomyces pombe)
RHEA:71111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(out) + S-methylmercury-L-cysteine(in) = L-phenylalanine(in) + S-methylmercury-L-cysteine(out)
REACT:R-CEL-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Caenorhabditis elegans)
REACT:R-PFA-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Plasmodium falciparum)
EC:1.1.1.116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arabinose 1-dehydrogenase (NAD(+))"
EC:1.1.1.116	skos:prefLabel	"D-arabinose 1-dehydrogenase (NAD(+))"
RHEA:13856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylene-L-glutamate + ATP + NH4(+) <=> 4-methylene-L-glutamine + AMP + diphosphate + H(+)
RHEA:10192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sulfate(out) = ADP + H(+) + phosphate + sulfate(in)
REACT:R-XTR-977333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Xenopus tropicalis)
REACT:R-DRE-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Danio rerio)
RHEA:17704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + geranoyl-CoA + hydrogencarbonate <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate
REACT:R-CEL-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
REACT:R-CFA-2187355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters phosphorylated SMAD2/3 (Canis familiaris)
REACT:R-CFA-2022411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)
REACT:R-SSC-9692738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds HRH2 antagonists (Sus scrofa)
REACT:R-MMU-8878787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPI dimer hydrolyses phosphate monoesters (Mus musculus)
REACT:R-MMU-2318623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aggrecan binds Hyaluronan and HAPLN1 (Mus musculus)
GO:0106335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity
REACT:R-RNO-8944225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVII (Rattus norvegicus)
GO:0008999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribosomal protein S18 acetyltransferase activity
GO:0008999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity
GO:0008999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-alanine-alpha-N-acetyltransferase activity
GO:0008999	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribosomal-protein-alanine N-acetyltransferase activity
REACT:R-DDI-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Dictyostelium discoideum)
REACT:R-MMU-8856223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Mus musculus)
RHEA:34337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
REACT:R-RNO-5691006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Rattus norvegicus)
REACT:R-CEL-418858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhoGTPase GEF's recruited to DCC (Caenorhabditis elegans)
REACT:R-RNO-379393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:56085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-O-phosphocholine-L-serine + H2O => [Rab1 protein]-L-serine + H(+) + phosphocholine
REACT:R-SSC-6807214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Sus scrofa)
RHEA:70430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phenylacetyl-CoA <=> 2-phenylacetate + CoA + H(+)
RHEA:66221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asc-omegaC7-CoA + O2 => asc-omegaDeltaC7-CoA + H2O2
RHEA:19566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O => diphosphate + sabinene hydrate
GO:0016756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytochelatin synthase activity
GO:0016756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity
GO:0016756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione gamma-glutamylcysteinyltransferase activity
GO:0016756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamylcysteine dipeptidyl transpeptidase activity
REACT:R-MMU-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Mus musculus)
GO:0047099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity
GO:0047099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-4-keto-6-deoxyglucose reductase activity
GO:0047099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity
GO:0047099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity
GO:0047099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-4-keto-deoxy-glucose reductase activity
GO:0047099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity
GO:0047099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-6-deoxyglucose reductase activity
GO:0047099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity
RHEA:71926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurochenodeoxycholate(out) <=> 2 Na(+)(in) + taurochenodeoxycholate(in)
REACT:R-CEL-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Caenorhabditis elegans)
REACT:R-BTA-9750226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 binds IKBKB and CHUK (Bos taurus)
RHEA:12306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + H2O + NADP(+)
REACT:R-DRE-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)
RHEA:54034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+) => (6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose
RHEA:31239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I
REACT:R-BTA-1592398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP8 (Bos taurus)
RHEA:12214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-fluoren-9-one + H(+) + NADPH => 9H-fluoren-9-ol + NADP(+)
GO:0102707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity
REACT:R-HSA-6814549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
RHEA:28743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(in) + nitrite(out) = nitrate(out) + nitrite(in)
GO:0103098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP79F1 tetrahomomethionine monooxygenase activity
REACT:R-DME-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Drosophila melanogaster)
RHEA:31014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> camelliol C
REACT:R-XTR-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Xenopus tropicalis)
RHEA:59395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-seryl-[protein] <=> CoA + O-acetyl-L-seryl-[protein]
RHEA:68837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate => (6R,7S)-himachala-9,11-diene + diphosphate
RHEA:62067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose 6-phosphate + NAD(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH
REACT:R-SSC-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Sus scrofa)
RHEA:53526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:36794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-hydroxy-L-arginine <=> hydroxyurea + L-ornithine
RHEA:17892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphoethanolamine <=> acetaldehyde + NH4(+) + phosphate
GO:0047026	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha-hydroxysteroid dehydrogenase (A-specific)
GO:0047026	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3-alpha-hydroxysteroid dehydrogenase (A-specific) activity
GO:0047026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone dehydrogenase (A-specific) activity
GO:0047026	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)
RHEA:56699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + L-tryptophan <=> (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate
GO:0102976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	versiconal reductase activity
RHEA:62320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-isomalbrancheamide B + FADH2
RHEA:10849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an [alpha-factor](in) + ATP + H2O => ADP + an [alpha-factor](out) + H(+) + phosphate
RHEA:12103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose <=> H2O + microthecin
RHEA:66124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxobutanoate + L-histidine = (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate
RHEA:33102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + spermine <=> CoA + H(+) + N(1)-acetylspermine
REACT:R-MMU-8985950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y649-STAT5A, p-STAT5B dimerizes (Mus musculus)
REACT:R-GGA-4086083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of ING2 with SUMO1 (Gallus gallus)
RHEA:11489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + an acyl-CoA => an all-trans-retinyl ester + CoA
RHEA:69292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = goitrin + sulfate
RHEA:37981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine
REACT:R-HSA-8850794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK5 (Homo sapiens)
RHEA:41788	skos:altLabel	"acyl-carrier-protein acetyltransferase"
RHEA:41788	skos:altLabel	"ACP acetyltransferase"
RHEA:41788	skos:altLabel	"acetyl coenzyme A-acyl-carrier-protein transacylase"
RHEA:41788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA
RHEA:41788	skos:prefLabel	"[acyl-carrier-protein] S-acetyltransferase"
RHEA:41788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[acyl-carrier-protein] S-acetyltransferase"
REACT:R-HSA-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Homo sapiens)
REACT:R-HSA-8953356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of EXTL2 (Homo sapiens)
REACT:R-GGA-5625416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anterograde IFT (Gallus gallus)
REACT:R-SPO-350567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Antizyme OAZ binds to Ornithine decarboxylase (Schizosaccharomyces pombe)
REACT:R-DDI-1855222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Dictyostelium discoideum)
REACT:R-DME-166220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion diffuses laterally to UCP (Drosophila melanogaster)
REACT:R-BTA-2213241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of nonameric complex (Bos taurus)
RHEA:66510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:15696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 <=> (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O
REACT:R-GGA-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Gallus gallus)
REACT:R-XTR-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Xenopus tropicalis)
REACT:R-SPO-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Schizosaccharomyces pombe)
RHEA:23505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)inamide + H2O => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate
REACT:R-BTA-375395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5a receptor binds C5a anaphylatoxin (Bos taurus)
REACT:R-BTA-8959462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Bos taurus)
REACT:R-DME-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Drosophila melanogaster)
REACT:R-SSC-6783177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates GATA3,IL33 (Sus scrofa)
REACT:R-HSA-5607737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 oligomerizes (Homo sapiens)
RHEA:32019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate
RHEA:32019	skos:prefLabel	"beta-cubebene synthase"
RHEA:32019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-cubebene synthase"
REACT:R-GGA-159728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-prothrombin to prothrombin (Gallus gallus)
RHEA:63208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(D-ribitylamino)uracil + glyoxal = 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O
RHEA:44772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)
REACT:R-HSA-9603986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 chains to form LeA (Homo sapiens)
REACT:R-RNO-77323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Rattus norvegicus)
REACT:R-RNO-174110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Rattus norvegicus)
RHEA:13582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP
REACT:R-MMU-750988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (z) reassociates with G beta:gamma (Mus musculus)
RHEA:52968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hyocholate + UDP-alpha-D-glucuronate = H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP
REACT:R-XTR-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Xenopus tropicalis)
RHEA:29983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(in) + H(+)(in) = cytidine(out) + H(+)(out)
REACT:R-MMU-1462014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-defensins form biologically active dimers (Mus musculus)
REACT:R-HSA-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Homo sapiens)
REACT:R-HSA-6797271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of MAOA (Homo sapiens)
REACT:R-BTA-444647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3a receptor binds anaphylatoxin C3a (Bos taurus)
RHEA:43999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 <=> a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate
REACT:R-GGA-5683831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCDC59 binds TTF1 (Gallus gallus)
REACT:R-DDI-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Dictyostelium discoideum)
REACT:R-BTA-449734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of glucosamine 6-phosphate to GlcNAc6P (Bos taurus)
GO:0050078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonate coenzyme A-transferase activity
GO:0050078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:malonate CoA-transferase activity
GO:0050078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonate CoA-transferase activity
RHEA:65592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Canis familiaris)
REACT:R-DRE-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Danio rerio)
REACT:R-SSC-196857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK2 phosphorylates PanK (Sus scrofa)
RHEA:55965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)
REACT:R-GGA-2172666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds condensin II (Gallus gallus)
REACT:R-XTR-9006844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21:IL21R:JAK1 binds IL2RG:JAK3 (Xenopus tropicalis)
REACT:R-XTR-3322422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits SMARCA4 (Xenopus tropicalis)
RHEA:71179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(out) + L-tryptophan(in) = L-histidine(in) + L-tryptophan(out)
RHEA:62208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Xenopus tropicalis)
RHEA:65807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine
REACT:R-MMU-205319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of APS and p-KIT (Mus musculus)
RHEA:35894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:46691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-oyl-CoA + A <=> 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2
REACT:R-SCE-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Saccharomyces cerevisiae)
REACT:R-HSA-390835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD1,5 bind DA (Homo sapiens)
REACT:R-HSA-1839114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 (Homo sapiens)
RHEA:32830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + methionine(out) <=> ADP + H(+) + methionine(in) + phosphate
REACT:R-MMU-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Mus musculus)
RHEA:71853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate(in) => glycocholate(out)
RHEA:13148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate <=> alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine
GO:0032559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenyl ribonucleotide binding
REACT:R-HSA-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Homo sapiens)
REACT:R-HSA-9634884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds CDK5 gene promoter (Homo sapiens)
REACT:R-SSC-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)
RHEA:72779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + O2 + ochratoxin B = FAD + 2 H2O + ochratoxin A
RHEA:70136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9027321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)
RHEA:36430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-171087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR [endosome membrane] => LDLR [plasma membrane] (Sus scrofa)
RHEA:71964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) => (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)
RHEA:11119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an alkane-alpha,omega-diamine <=> an N-acetylalkane-alpha,omega-diamine + CoA + H(+)
RHEA:55054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + pentanoate => H2O + pentanoyl-CoA
REACT:R-CEL-549297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-XTR-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Xenopus tropicalis)
RHEA:55334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 3'-hydroxyflavone + S-adenosyl-L-methionine
RHEA:40473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-(2E)-pentadecenoyl-CoA + H2O2 => (2S)-methylpentadecanoyl-CoA + O2
GO:0015544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenyl propionate uniporter activity
GO:0015544	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenyl propionate permease activity
REACT:R-DRE-416639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Danio rerio)
REACT:R-GGA-8937442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES3 hydrolyses CHEST to CHOL and LCFA(-) (Gallus gallus)
GO:0050635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acridone synthase activity
GO:0050635	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)
RHEA:42714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(54) in tRNA
REACT:R-CFA-3321805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSL acetylates histone H4 (Canis familiaris)
RHEA:25504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = beta-phellandrene + diphosphate
REACT:R-SCE-200474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)
REACT:R-RNO-162821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)
REACT:R-HSA-6781897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP11 deubiquitinates NFKBIA (Homo sapiens)
REACT:R-DME-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Drosophila melanogaster)
REACT:R-DME-390649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind acetylcholine (Drosophila melanogaster)
RHEA:54651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O
RHEA:12507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH
REACT:R-DRE-450488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRF1 Complex recruits RNA degradation activities (Danio rerio)
REACT:R-MMU-9020278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Mus musculus)
RHEA:56945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + D-ribulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + A + H2O
REACT:R-SPO-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Schizosaccharomyces pombe)
REACT:R-DRE-2396002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Danio rerio)
RHEA:57260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate
RHEA:48626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2
REACT:R-DME-209272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-HH binds to the transmembrane HSPG proteins (Drosophila melanogaster)
RHEA:16600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NH4(+) + UTP <=> ADP + CTP + 2 H(+) + phosphate
RHEA:41795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[ACP] + malonyl-CoA <=> CoA + malonyl-[ACP]
RHEA:67520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
REACT:R-RNO-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Rattus norvegicus)
REACT:R-GGA-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Gallus gallus)
RHEA:66032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose
REACT:R-HSA-5683831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCDC59 binds TTF1 (Homo sapiens)
RHEA:47359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an octanoate ester + H2O <=> an aliphatic alcohol + H(+) + octanoate
REACT:R-GGA-9674816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Gallus gallus)
RHEA:35926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP
EC:1.2.1.15	skos:prefLabel	"malonate-semialdehyde dehydrogenase"
EC:1.2.1.15	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malonate-semialdehyde dehydrogenase"
REACT:R-HSA-419389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPA-binding receptors bind LPA (Homo sapiens)
REACT:R-SSC-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Sus scrofa)
REACT:R-DME-174255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)
REACT:R-RNO-9033491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Rattus norvegicus)
RHEA:21858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxycyclohex-1-ene-1-carbonyl-CoA => cyclohexa-1,5-diene-1-carbonyl-CoA + H2O
REACT:R-BTA-5195402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates LPIN (Bos taurus)
REACT:R-SSC-5693012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF15 binds TNFRSF25 (Sus scrofa)
RHEA:48152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b(d18:1(4E)/18:0) + H2O = ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate
REACT:R-XTR-3371586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90 complex (Xenopus tropicalis)
RHEA:21562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dithiothreitol + 2,3-epoxyphylloquinone => 3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol
GO:0047805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidylate cyclase activity
GO:0047805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP = 3',5'-cyclic CMP + diphosphate
GO:0047805	skos:altLabel	"cytidyl cyclase"
GO:0047805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'5'-cyclic-CMP synthase activity
GO:0047805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3',5'-cyclic-CMP synthase activity
GO:0047805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidyl cyclase activity
GO:0047805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidylyl cyclase activity
GO:0047805	skos:altLabel	"cytidylyl cyclase"
GO:0047805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytidylate cyclase"
GO:0047805	skos:altLabel	"3'5'-cyclic-CMP synthase"
GO:0047805	skos:prefLabel	"cytidylate cyclase"
GO:0047805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)
GO:0047805	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP diphosphate-lyase (cyclizing)
REACT:R-SSC-193101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11A1 cleaves 20a,22b-DHCHOL (Sus scrofa)
RHEA:40812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
RHEA:17962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => H2O + leukotriene A4
RHEA:48777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-193424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
REACT:R-GGA-9657599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
GO:0030294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor signaling protein tyrosine kinase inhibitor activity
GO:0030294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor signalling protein tyrosine kinase inhibitor activity
RHEA:44584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)
REACT:R-CEL-201472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Caenorhabditis elegans)
REACT:R-DRE-6807055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR7 reduces 7-dehydroCHOL to CHOL (Danio rerio)
REACT:R-GGA-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Gallus gallus)
REACT:R-RNO-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Rattus norvegicus)
REACT:R-MMU-1678708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGSH hydrolyses Heparan sulfate chain(2) (Mus musculus)
GO:0005464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-xylose transmembrane transporter activity
GO:0005464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Homo sapiens)
REACT:R-MMU-9607304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Mus musculus)
RHEA:51826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octanoate(out)
REACT:R-HSA-9664862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:PEX5 phosphorylates PEX5 (Homo sapiens)
GO:0099142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intracellularly ATP-gated ion channel activity
REACT:R-HSA-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Homo sapiens)
REACT:R-XTR-5665767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FMNL3 binds G-actin (Xenopus tropicalis)
RHEA:52545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythronate + NAD(+) => 2-dehydro-D-erythronate + H(+) + NADH
RHEA:32601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-isopropenyl-6-oxoheptanoate + H(+) => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one
RHEA:59405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine => D-homoserine
REACT:R-GGA-5693593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop extension by DNA polymerases (Gallus gallus)
RHEA:52246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 4 Mn(3+) => 4 H(+) + 4 Mn(2+) + O2
REACT:R-CFA-109343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Canis familiaris)
REACT:R-HSA-9016916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 coactivator complex binds the PTCRA gene promoter (Homo sapiens)
RHEA:29752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate(in) => acetoacetate(out)
RHEA:14611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-L-sorbose + NADPH => D-sorbitol + NADP(+)
REACT:R-MMU-74376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Mus musculus)
REACT:R-SSC-75998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD52 heptameric ring structure complexes (Sus scrofa)
RHEA:22475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantetheine + ATP <=> (R)-4'-phosphopantetheine + ADP + H(+)
RHEA:46284	skos:altLabel	"acyl-lipid 6-desaturase"
RHEA:46284	skos:altLabel	"Delta(6)-desaturase"
RHEA:46284	skos:prefLabel	"acyl-lipid (9-3)-desaturase"
RHEA:46284	skos:altLabel	"acyl-lipid Delta(6)-desaturase"
RHEA:46284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid (9-3)-desaturase"
RHEA:46284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:48346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-galactosylceramide + H(+) + UDP => an N-acyl-sphingoid base + UDP-alpha-D-galactose
REACT:R-CFA-2395512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDXR transfers electrons to FDX1,2 (FDX1L) (Canis familiaris)
REACT:R-HSA-1592231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of CYCS (Homo sapiens)
REACT:R-SSC-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Sus scrofa)
REACT:R-GGA-421174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + orthophosphate <=> hypoxanthine + D-ribose 1-phosphate (Gallus gallus)
RHEA:18563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)
REACT:R-HSA-5634100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 dissociates from RXRA:PPARD:atRA (Homo sapiens)
REACT:R-BTA-202500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of IKK complex (Bos taurus)
RHEA:11254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-L-aspartylhydroxamate + NH4(+) => H(+) + hydroxylamine + L-asparagine
RHEA:59537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + butanoyl-CoA + hydrogencarbonate => (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate
RHEA:42895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + H(+) + H2O <=> 5'-deoxyinosine + NH4(+)
REACT:R-HSA-6798611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates and ZNF420 inhibits TP53AIP1 expression (Homo sapiens)
REACT:R-BTA-517536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Bos taurus)
REACT:R-XTR-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-BTA-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)
EC:1.19.1.-	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
EC:1.19.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
REACT:R-BTA-5662662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosinase oxidises tyrosine to dopaquinone (Bos taurus)
RHEA:71781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate(in) + H(+)(in) => 4-methyl-2-oxopentanoate(out) + H(+)(out)
RHEA:22610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,6S)-2,6-diaminoheptanedioate + succinate => H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate
GO:0008512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate:hydrogen symporter activity
GO:0008512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphate:hydrogen symporter activity
GO:0008512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate/hydrogen symporter activity
GO:0008512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate:proton symporter activity
EC:2.1.1.353	skos:prefLabel	"demethylluteothin O-methyltransferase"
EC:2.1.1.353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethylluteothin O-methyltransferase"
REACT:R-SCE-5681981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG3 transfers LC3 from ATG7 to ATG3 (Saccharomyces cerevisiae)
RHEA:26068	skos:prefLabel	"2-phosphinomethylmalate synthase"
RHEA:26068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-phosphinomethylmalate synthase"
RHEA:26068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O = CoA + H(+) + phosphinomethylmalate
RHEA:30888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin => 7,8-dihydropteroate + H2O
RHEA:43736	skos:altLabel	"m(6)A(2030) methyltransferase"
RHEA:43736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine
RHEA:43736	skos:prefLabel	"23S rRNA (adenine(2030)-N(6))-methyltransferase"
RHEA:43736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (adenine(2030)-N(6))-methyltransferase"
EC:2.6.1.6	skos:prefLabel	"leucine transaminase"
EC:2.6.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"leucine transaminase"
EC:2.6.1.6	skos:altLabel	"leucine aminotransferase"
REACT:R-DME-77585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Drosophila melanogaster)
RHEA:31829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-gamma-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:58083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-docosanoylglycerol + H2O <=> docosanoate + glycerol + H(+)
REACT:R-RNO-8987132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Rattus norvegicus)
REACT:R-SSC-6785165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Sus scrofa)
RHEA:71529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine(in) => thymine(out)
REACT:R-XTR-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Xenopus tropicalis)
GO:0052626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate amino acid synthetase activity
GO:0052626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl amino acid synthetase activity
RHEA:46329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threo-3-phenylserine => 3-phenylpyruvate + NH4(+)
REACT:R-MMU-1592371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP3 (Mus musculus)
RHEA:12347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) <=> H(+) + L-glutamyl-tRNA(Glu) + NADPH
REACT:R-CEL-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Caenorhabditis elegans)
REACT:R-MMU-6814671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of late-endosome derived vesicles at the TGN (Mus musculus)
RHEA:29951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + uridine(in) = H(+)(out) + uridine(out)
REACT:R-CFA-914036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)
REACT:R-DRE-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Danio rerio)
REACT:R-CEL-2408524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Caenorhabditis elegans)
REACT:R-SCE-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Saccharomyces cerevisiae)
RHEA:55843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP
RHEA:18434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexylamine + H2O + O2 => cyclohexanone + H2O2 + NH4(+)
REACT:R-XTR-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Xenopus tropicalis)
RHEA:23596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate
RHEA:23596	skos:prefLabel	"UDP-glucose 6-dehydrogenase"
RHEA:23596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-glucose 6-dehydrogenase"
REACT:R-SSC-8866851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transits to the plasma membrane (Sus scrofa)
REACT:R-DME-5654426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
RHEA:68734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase] => ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-9652264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 binds TKIs (Canis familiaris)
RHEA:17574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylmacrocin + S-adenosyl-L-methionine => H(+) + macrocin + S-adenosyl-L-homocysteine
REACT:R-RNO-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Rattus norvegicus)
RHEA:35000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(in) + ATP(out) => ADP(out) + ATP(in)
RHEA:69562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(in) + H(+)(in) => D-mannose(out) + H(+)(out)
RHEA:62845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)
RHEA:64471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH
REACT:R-MMU-4570493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Mus musculus)
REACT:R-SSC-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Sus scrofa)
REACT:R-DRE-9014294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the plasma membrane (Danio rerio)
REACT:R-SSC-9611751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1,2-agonists bind ADRB1,2 (Sus scrofa)
GO:0043844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-Pfk activity
GO:0043844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-6-phosphofructokinase activity
GO:0043844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-dependent phosphofructokinase activity
GO:0043844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-specific phosphofructokinase activity
GO:0043844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP:D-fructose-6-phosphate 1-phosphotransferase activity
REACT:R-SSC-1678920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR processing at low pH (Sus scrofa)
RHEA:63677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH
REACT:R-DRE-8848087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAP2 recruits STAT3 to PTK6 (Danio rerio)
REACT:R-MMU-5578783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Mus musculus)
RHEA:34477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 2 diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-BTA-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Bos taurus)
REACT:R-XTR-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Xenopus tropicalis)
REACT:R-GGA-416690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4A binds to PLXND1 (Gallus gallus)
RHEA:69669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + luteolin => H2O + luteolin 4'-O-beta-D-glucoside
REACT:R-DME-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Drosophila melanogaster)
REACT:R-DME-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Drosophila melanogaster)
REACT:R-SSC-8853444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PHLDA1 (Sus scrofa)
REACT:R-DME-74885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCYs converts GTP to cGMP (Drosophila melanogaster)
REACT:R-SSC-9014296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GEFs activate RAC2 (Sus scrofa)
REACT:R-BTA-5692437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANG binds F-actin (Bos taurus)
GO:0019811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cocaine binding
RHEA:30091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + D-alanine + H2O = a ubiquinol + NH4(+) + pyruvate
RHEA:46160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H(+) + NADH = a quinol + NAD(+)
REACT:R-CEL-2213207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen networks (Caenorhabditis elegans)
RHEA:39993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine => (4R)-hydroxyeicosasphinganine + a fatty acyl-CoA
RHEA:11141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate => D-mannose 6-phosphate
REACT:R-CEL-203979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coat Assembly (Caenorhabditis elegans)
GO:0018114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	threonine racemase activity
RHEA:23060	skos:prefLabel	"olefin beta-lactone synthetase"
RHEA:23060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP = a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate
RHEA:23060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"olefin beta-lactone synthetase"
RHEA:40410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
RHEA:57703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine
REACT:R-CFA-9008052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10(?-152) binds IL1RAPL1 (Canis familiaris)
REACT:R-SSC-1471338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins 1, 4A and 103 bind CCR6 (Sus scrofa)
RHEA:22182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-norcodamine + H(+) + S-adenosyl-L-homocysteine => (S)-norreticuline + S-adenosyl-L-methionine
RHEA:12654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NAD(+) => CO2 + NADH + pyruvate
REACT:R-GGA-374922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenalin synaptic vesicle docking and priming (Gallus gallus)
REACT:R-CEL-2129357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin C-terminal processing (Caenorhabditis elegans)
REACT:R-HSA-1989767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TRIB3 (Homo sapiens)
RHEA:63866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroperoxyoctadecanoate => O2 + octadecanoate
EC:3.4.22.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"streptopain"
EC:3.4.22.10	skos:prefLabel	"streptopain"
EC:3.4.22.10	skos:altLabel	"streptococcal proteinase"
EC:3.4.22.10	skos:altLabel	"streptococcal cysteine proteinase"
EC:3.4.22.10	skos:altLabel	"Streptococcus peptidase A"
REACT:R-SSC-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Sus scrofa)
GO:0102122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A34 + S-adenosyl-L-methionine = O-methyl gibberellin A34 + S-adenosyl-L-homocysteine
GO:0102122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A34 carboxyl methyltransferase activity
REACT:R-HSA-2301205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD8 monomethylates histone H4 (Homo sapiens)
REACT:R-SPO-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Schizosaccharomyces pombe)
REACT:R-HSA-3000243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl (Homo sapiens)
RHEA:20244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate + S-adenosyl-L-methionine <=> N-methylnicotinate + S-adenosyl-L-homocysteine
REACT:R-BTA-168412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP elicits a NOD2 response (Bos taurus)
REACT:R-HSA-9702623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorafenib-resistant FLT3 mutants don't bind sorafenib (Homo sapiens)
REACT:R-SSC-446218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first mannose to the N-glycan precursor by ALG1 (Sus scrofa)
RHEA:40348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxotetradecanedioyl-CoA + CoA => acetyl-CoA + dodecanedioyl-CoA
REACT:R-HSA-8986446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26 binds IL20RA:JAK1 (Homo sapiens)
RHEA:52357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + pregnenolone => adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate
REACT:R-XTR-9634861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT2 (Xenopus tropicalis)
REACT:R-HSA-9036020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)8 (PP-Dol)1 by ALG9 (Homo sapiens)
REACT:R-MMU-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Mus musculus)
RHEA:40835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine
REACT:R-BTA-434836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syk/Lck phosphorylate LAT (Bos taurus)
REACT:R-BTA-1112666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)
RHEA:52784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfenohercynine + AH2 + H(+) = A + ergothioneine + H2O
REACT:R-DME-183002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Drosophila melanogaster)
RHEA:48625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 => (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate
REACT:R-HSA-2426152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,2 binds the IDI1 promoter (Homo sapiens)
REACT:R-MMU-8866546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF5 and RNF185 ubiquitinate misfolded CFTR (Mus musculus)
REACT:R-HSA-977224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serum amyloid P binds DNA and chromatin (Homo sapiens)
RHEA:38879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid(in) = a fatty acid(out)
REACT:R-CFA-8864595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2B homodimer binds YEATS4 (Canis familiaris)
REACT:R-BTA-9037761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)
RHEA:30570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate <=> 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate
REACT:R-XTR-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Xenopus tropicalis)
REACT:R-BTA-209125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Bos taurus)
REACT:R-HSA-182286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
RHEA:13874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate => abieta-7,13-diene + diphosphate
RHEA:55882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[aequorin] => apo-[aequorin]--coelenterazine + O2
REACT:R-HSA-200512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)
RHEA:38559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate = (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:17790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine => (S)-reticuline + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-1433451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 binds to p-KIT (Xenopus tropicalis)
EC:1.14.15.33	skos:prefLabel	"pikromycin synthase"
EC:1.14.15.33	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pikromycin synthase"
EC:1.14.15.33	skos:altLabel	"CYP107L1"
REACT:R-RNO-964962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDKX:2xZn2+ phosphorylates PDX (Rattus norvegicus)
RHEA:24150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Homo sapiens)
REACT:R-DDI-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)
RHEA:57650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	equisetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trichosetin
REACT:R-BTA-1678650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDS hydrolyses Heparan sulfate chain(5) (Bos taurus)
REACT:R-BTA-9735946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET small tyrosine kinase inhibitors bind MET (Bos taurus)
REACT:R-DRE-1605797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) (Danio rerio)
REACT:R-HSA-3780995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 (Homo sapiens)
GO:0102320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-cineole 2-exo-monooxygenase activity
RHEA:14892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate <=> (5Z,7E,9E,14Z,17Z)-icosapentaenoate
RHEA:43128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine
RHEA:43128	skos:prefLabel	"tRNA (guanine(10)-N(2))-methyltransferase"
RHEA:43128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (guanine(10)-N(2))-methyltransferase"
GO:0008401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	retinoic acid 4-hydroxylase activity
GO:0008401	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP261
REACT:R-HSA-2473594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP15 (Homo sapiens)
REACT:R-BTA-5653786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)
RHEA:30978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 5 A <=> 5 AH2 + all-trans-3,4-didehydrolycopene
REACT:R-GGA-2730864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TRAF6 to CBM complex by binding to MALT1 (Gallus gallus)
REACT:R-CFA-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Canis familiaris)
REACT:R-SSC-5610720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates GLI3 (Sus scrofa)
REACT:R-DRE-388814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds CD28 (Danio rerio)
RHEA:70122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-9706323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA2 (Bos taurus)
RHEA:45659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-BTA-418436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)
RHEA:36940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA => (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0004814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine translase activity
GO:0004814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine-tRNA ligase activity
GO:0004814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginyl-transfer RNA synthetase activity
GO:0004814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginyl transfer ribonucleic acid synthetase activity
GO:0004814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine-tRNA synthetase activity
GO:0004814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginyl-transfer ribonucleate synthetase activity
GO:0004814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginyl-tRNA synthetase activity
GO:0004814	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-arginine:tRNAArg ligase (AMP-forming)
REACT:R-HSA-193706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Production of ceramide which can activate JNK and other targets (Homo sapiens)
REACT:R-XTR-9759169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Xenopus tropicalis)
RHEA:49744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyviolaceinate + H(+) + O2 = CO2 + deoxyviolacein + H2O
RHEA:20619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O2 + L-ascorbate => L-galactono-1,4-lactone + O2
REACT:R-MMU-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)
RHEA:58134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine => A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:59642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotetraono-1,5-lactone + H2O2 => D-xylotetraose + O2
RHEA:53947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) <=> (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH
REACT:R-HSA-1022127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Homo sapiens)
REACT:R-RNO-204947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF migrates to the nucleus (Rattus norvegicus)
REACT:R-XTR-1433454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of GAB2 by SFKs (Xenopus tropicalis)
RHEA:39633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH
RHEA:13461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 = 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)
REACT:R-MMU-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Mus musculus)
RHEA:37834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate
RHEA:31914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 1,6-bisphosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate
REACT:R-BTA-382613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Bos taurus)
REACT:R-DRE-1602398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Danio rerio)
REACT:R-HSA-5422942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXRA:PPARD binds FABP5:atRA (Homo sapiens)
RHEA:34227	skos:prefLabel	"5-nitrosalicylate dioxygenase"
RHEA:34227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-nitrosalicylate dioxygenase"
RHEA:34227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-nitrosalicylate + O2 = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite
RHEA:22549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysine + O2 => (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)
RHEA:17576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylmacrocin + S-adenosyl-L-methionine <=> H(+) + macrocin + S-adenosyl-L-homocysteine
REACT:R-SSC-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Sus scrofa)
REACT:R-HSA-9681514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMPRSS2 binds TMPRSS2 inhibitors (Homo sapiens)
REACT:R-BTA-6814885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)
REACT:R-DDI-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Dictyostelium discoideum)
REACT:R-XTR-8953946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Xenopus tropicalis)
RHEA:43201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)
REACT:R-MMU-5607750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Mus musculus)
REACT:R-SPO-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Schizosaccharomyces pombe)
RHEA:69825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-PFA-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Plasmodium falciparum)
REACT:R-HSA-8847995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)
RHEA:65445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + hexan-1-ol => CoA + hexyl butanoate
REACT:R-BTA-8851797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 in ADRB2:GRK complex is phosphorylated (Bos taurus)
RHEA:54094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,5-trihydroxyphenylacetate + H2O + NADP(+) => 3,4-dihydroxyphenylacetate + H(+) + NADPH + O2
RHEA:70671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]
RHEA:60038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methylhexanoate + L-glutamine => H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate
REACT:R-GGA-5218814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 autophorylates (Gallus gallus)
REACT:R-RNO-5654592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)
REACT:R-HSA-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Homo sapiens)
RHEA:50217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate
REACT:R-HSA-8867044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)
RHEA:56347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7-hydroxyisoflavone + UDP-alpha-D-glucose <=> a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP
REACT:R-HSA-1592247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ATP5B (Homo sapiens)
REACT:R-RNO-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Rattus norvegicus)
RHEA:40012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate + H2O => diphosphate + manool
REACT:R-SSC-8849906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM1 binds NMDA receptor (Sus scrofa)
REACT:R-CFA-6804229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMY, TTC5 and EP300 bind (Canis familiaris)
REACT:R-XTR-983424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of COPII coated vesicle (Xenopus tropicalis)
GO:0055077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction hemi-channel activity
GO:0055077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	connexon channel activity
RHEA:41969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) => a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)
RHEA:70191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NAD(+) = 3'-NADP(+) + ADP + H(+)
REACT:R-DRE-430183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK binds PAK (Danio rerio)
RHEA:70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2
REACT:R-BTA-6797913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARDH:FAD oxidatively demethylates SARC to Gly (Bos taurus)
REACT:R-RNO-174368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Rattus norvegicus)
RHEA:54773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate
REACT:R-SSC-351947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of catalytic domain of Mst3 (Sus scrofa)
REACT:R-BTA-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Bos taurus)
REACT:R-SSC-5675206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEA15 binds MAPK monomers and dimers (Sus scrofa)
REACT:R-SSC-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Sus scrofa)
REACT:R-MMU-163010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Down Regulation of Emi1 through Phosphorylation of Emi1 (Mus musculus)
RHEA:70386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-3-oxosphinganine
RHEA:12847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n) + H2O
REACT:R-GGA-443986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor ACKR2 binds most inflammatory CC chemokines (Gallus gallus)
REACT:R-GGA-9647978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-RAS proteins are farnesylated (Gallus gallus)
RHEA:33564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + ATP => (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)
RHEA:15909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"taurine dioxygenase"
RHEA:15909	skos:altLabel	"2-aminoethanesulfonate dioxygenase"
RHEA:15909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + H(+) + succinate + sulfite
RHEA:15909	skos:altLabel	"alpha-ketoglutarate-dependent taurine dioxygenase"
RHEA:15909	skos:prefLabel	"taurine dioxygenase"
GO:0000287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg binding
GO:0000287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	magnesium binding
GO:0000287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	magnesium ion binding
GO:0062192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnose = beta-L-rhamnose
GO:0062192	skos:altLabel	"rhamnose 1-epimerase"
GO:0062192	skos:prefLabel	"L-rhamnose mutarotase"
GO:0062192	skos:altLabel	"type-3 mutarotase"
GO:0062192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-rhamnose mutarotase"
GO:0062192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnose mutarotase activity
REACT:R-GGA-5668735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX3 complex (Gallus gallus)
REACT:R-MMU-9618378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 binds the Nup107-Nup160 complex (Mus musculus)
GO:0005463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylgalactosamine transmembrane transporter activity
REACT:R-HSA-8944706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-21 nonendonucleolytic RISC binds PTEN mRNA (Homo sapiens)
REACT:R-BTA-3296233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T2Rs bind bitter-tasting compounds (Bos taurus)
REACT:R-DRE-9033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX7 binds cargo proteins containing PTS2 (Danio rerio)
EC:1.14.13.211	skos:prefLabel	"rifampicin monooxygenase"
EC:1.14.13.211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"rifampicin monooxygenase"
EC:1.14.13.211	skos:altLabel	"RIF-O"
REACT:R-HSA-114671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vWF binds to collagen (Homo sapiens)
REACT:R-MMU-1638803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
REACT:R-CFA-193533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)
REACT:R-DME-549297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Drosophila melanogaster)
REACT:R-HSA-844618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dsDNA:AIM2:ASC cluster binds procaspase-1 (Homo sapiens)
REACT:R-SCE-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)
RHEA:18335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + oleandomycin 2'-O-phosphate => ATP + oleandomycin
REACT:R-CFA-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Canis familiaris)
REACT:R-GGA-170159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cdc25 to the nucleus (Gallus gallus)
REACT:R-DME-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Drosophila melanogaster)
RHEA:23800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionine gamma-lyase"
RHEA:23800	skos:altLabel	"methionine lyase"
RHEA:23800	skos:altLabel	"L-methioninase"
RHEA:23800	skos:prefLabel	"methionine gamma-lyase"
RHEA:23800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+)
RHEA:72553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + urate(out) => glutarate(out) + urate(in)
REACT:R-CFA-8941618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
GO:0070404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced NAD binding
GO:0070404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced nicotinamide adenine dinucleotide binding
GO:0070404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH binding
GO:0070404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD (reduced) binding
RHEA:38711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol
REACT:R-HSA-430096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GP1b-IX-V binds filamin (Homo sapiens)
REACT:R-HSA-6810594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Homo sapiens)
EC:3.2.2.3	skos:altLabel	"Uridine ribohydrolase"
EC:3.2.2.3	skos:prefLabel	"uridine nucleosidase"
EC:3.2.2.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uridine nucleosidase"
REACT:R-SSC-6805650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA2-NuRD complex deacetylates TP53 (Sus scrofa)
REACT:R-SPO-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Schizosaccharomyces pombe)
RHEA:14773	skos:prefLabel	"corydaline synthase"
RHEA:14773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"corydaline synthase"
RHEA:14773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 NADPH + palmatine + S-adenosyl-L-methionine = corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine
RHEA:31847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = shionone
RHEA:31847	skos:prefLabel	"shionone synthase"
RHEA:31847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"shionone synthase"
REACT:R-XTR-5684868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPC translocates from ER membrane to multivesicle body (Xenopus tropicalis)
GO:0050124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylneuraminate 9-phosphate + H2O = an N-acylneuraminate + phosphate
GO:0050124	skos:prefLabel	"N-acylneuraminate-9-phosphatase"
GO:0050124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acylneuraminic (sialic) acid 9-phosphatase activity
GO:0050124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylneuraminate-9-phosphatase activity
GO:0050124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylneuraminate 9-phosphatase activity
GO:0050124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acylneuraminic acid 9-phosphate phosphatase activity
GO:0050124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acylneuraminate-9-phosphatase"
GO:0050124	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acylneuraminate-9-phosphate phosphohydrolase activity
REACT:R-CEL-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Caenorhabditis elegans)
REACT:R-CFA-5690213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerases delta, epsilon or kappa bind the GG-NER site (Canis familiaris)
RHEA:19239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxymethyl-3-methylbut-2-en-1,4-olide => 4-carboxymethyl-4-methylbut-2-en-1,4-olide
REACT:R-CEL-8952058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 binds RUNX3 and displaces EP300 (Caenorhabditis elegans)
REACT:R-BTA-265424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Bos taurus)
REACT:R-BTA-5668731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX3 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)
REACT:R-MTU-936583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APS is phosphorylated to PAPS (Mycobacterium tuberculosis)
RHEA:64557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => 8-epi-ilicicolin H
REACT:R-SSC-5696220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to arsenite(3-) (Sus scrofa)
GO:0030272	skos:prefLabel	"5-formyltetrahydrofolate cyclo-ligase"
GO:0030272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methenyltetrahydrofolate synthetase activity
GO:0030272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methenyl-THF synthetase activity
GO:0030272	skos:altLabel	"5,10-methenyltetrahydrofolate synthetase"
GO:0030272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-Formyltetrahydrofolate cyclodehydrase activity
GO:0030272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyltetrahydrofolic cyclodehydrase activity
GO:0030272	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-formyltetrahydrofolate cyclo-ligase (ADP-forming)
GO:0030272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate
GO:0030272	skos:altLabel	"Methenyl-THF synthetase"
GO:0030272	skos:altLabel	"5-Formyltetrahydrofolate cyclodehydrase"
GO:0030272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-formyltetrahydrofolate cyclo-ligase"
GO:0030272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-formyltetrahydrofolate cyclo-ligase activity
GO:0030272	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	5-formyltetrahydrofolate cyclodehydrase
REACT:R-DDI-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Dictyostelium discoideum)
REACT:R-HSA-5672960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAB dimer dissociates from dephosphorylated RAF (Homo sapiens)
RHEA:45443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate
RHEA:26037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:63029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenamide + H2O => (15Z)-tetracosenoate + NH4(+)
RHEA:17777	skos:prefLabel	"1-alkyl-2-acetylglycerophosphocholine esterase"
RHEA:17777	skos:altLabel	"LDL-associated phospholipase A2"
RHEA:17777	skos:altLabel	"LDL-PLA2"
RHEA:17777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:17777	skos:altLabel	"PAF acetylhydrolase"
RHEA:17777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-alkyl-2-acetylglycerophosphocholine esterase"
RHEA:17777	skos:altLabel	"PAF 2-acylhydrolase"
RHEA:17777	skos:altLabel	"platelet-activating factor acetylhydrolase"
RHEA:17777	skos:altLabel	"2-acetyl-1-alkylglycerophosphocholine esterase"
REACT:R-CFA-5668414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
RHEA:64695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isobutanol + NAD(+) <=> 2-methylpropanal + H(+) + NADH
REACT:R-XTR-186798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binds to PDGF-beta receptors only (Xenopus tropicalis)
REACT:R-DME-350058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL NCOR corepressor complex (Drosophila melanogaster)
RHEA:35805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 2'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O
RHEA:25149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + quinolinate => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde
GO:0034859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzothiazole monooxygenase activity
RHEA:49059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperlicin C + H(+) + NADPH + O2 <=> asperlicin E + H2O + NADP(+)
REACT:R-HSA-9684068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)
RHEA:16581	skos:prefLabel	"cytochrome-c peroxidase"
RHEA:16581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 = 2 Fe(III)-[cytochrome c] + 2 H2O
RHEA:16581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytochrome-c peroxidase"
REACT:R-XTR-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Xenopus tropicalis)
REACT:R-HSA-964825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)
REACT:R-RNO-202723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha5beta1 binds FN1 dimer (Rattus norvegicus)
GO:0005542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin M binding
GO:0005542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folic acid binding
GO:0005542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	folate binding
GO:0005542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin B9 binding
RHEA:22238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O
REACT:R-HSA-8953452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
REACT:R-MMU-5626316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Mus musculus)
RHEA:12197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-fructose 6-phosphate + phosphate => acetyl phosphate + D-erythrose 4-phosphate + H2O
REACT:R-SCE-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Saccharomyces cerevisiae)
RHEA:62626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glutaredoxin]-disulfide + an alcohol + H2O => [glutaredoxin]-dithiol + a hydroperoxide
REACT:R-SSC-201475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with R-Smad1/5/8 for type I receptor (Sus scrofa)
REACT:R-MMU-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Mus musculus)
REACT:R-SSC-391940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP2 and EP4 receptors can bind PGE2 (Sus scrofa)
RHEA:56457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-fischerindole U
REACT:R-CFA-1855197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)
REACT:R-CFA-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Canis familiaris)
REACT:R-HSA-375342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 36 mediated neuronal gap junction communication (Homo sapiens)
RHEA:11184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(carbamoylamino)propanoate + 2 H(+) + H2O = beta-alanine + CO2 + NH4(+)
RHEA:64504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine = 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine
REACT:R-HSA-380620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reuptake of serotonin from the synapse (Homo sapiens)
REACT:R-PFA-5624948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF17 enters the cilium (Plasmodium falciparum)
RHEA:13625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cytokinin dehydrogenase"
RHEA:13625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + N(6)-dimethylallyladenine = 3-methyl-2-butenal + adenine + AH2
RHEA:13625	skos:prefLabel	"cytokinin dehydrogenase"
RHEA:13625	skos:altLabel	"cytokinin oxidase"
REACT:R-BTA-183089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)
REACT:R-SSC-193385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of choloyl-CoA to cholate and CoASH (Sus scrofa)
RHEA:54782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine
RHEA:50391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5a,11a-dehydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrooxytetracycline + H2O + NADP(+)
RHEA:27783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-octaprenyl diphosphate => 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate
RHEA:52081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-octadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + octadecanoate
REACT:R-DRE-1296024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in neuroendocrine cells (Danio rerio)
RHEA:41469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-5658430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF1 is degraded by the proteasome (Mus musculus)
REACT:R-MMU-1028816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Mus musculus)
REACT:R-SSC-417829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds ADP (Sus scrofa)
REACT:R-SSC-9757951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)
REACT:R-GGA-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Gallus gallus)
EC:2.5.1.139	skos:prefLabel	"umbelliferone 6-dimethylallyltransferase"
EC:2.5.1.139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"umbelliferone 6-dimethylallyltransferase"
RHEA:23251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + S-adenosyl-L-methionine <=> 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-8868660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)
RHEA:16755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+) => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2
RHEA:64581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate => diphosphate + nerylneryl diphosphate
REACT:R-HSA-5357845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is deubiquitinated (Homo sapiens)
RHEA:18635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate => 2 ATP + H2O + hydrogencarbonate + L-glutamine
RHEA:72642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine <=> 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine
REACT:R-HSA-170810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)
REACT:R-DME-5334854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAR:RXR binds SUMO-CRABP2:atRA (Drosophila melanogaster)
RHEA:57030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+) => FADH2 + N-methylnicotinate + O2
RHEA:34254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxysphinganine + NADP(+) <=> 1-deoxy-3-dehydrosphinganine + H(+) + NADPH
RHEA:12744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + H2O <=> IDP + NH4(+)
REACT:R-HSA-2731123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrin alphaVbeta3 (Homo sapiens)
RHEA:23656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)
RHEA:23656	skos:altLabel	"CMLE"
RHEA:23656	skos:prefLabel	"3-carboxy-cis,cis-muconate cycloisomerase"
RHEA:23656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-carboxy-cis,cis-muconate cycloisomerase"
RHEA:23656	skos:altLabel	"3-carboxymuconate lactonizing enzyme"
RHEA:23656	skos:altLabel	"beta-carboxymuconate lactonizing enzyme"
REACT:R-HSA-3301237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT2 complexes acetylate histone H3 (Homo sapiens)
RHEA:13855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylene-L-glutamine + AMP + diphosphate + H(+) => 4-methylene-L-glutamate + ATP + NH4(+)
RHEA:32900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-cineole + O2 + reduced [flavodoxin] => 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]
REACT:R-DME-2186643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEN1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)
RHEA:42234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:36684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + L-cysteinyl-[protein] => CoA + S-hexadecanoyl-L-cysteinyl-[protein]
REACT:R-XTR-1606789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses DS (Xenopus tropicalis)
RHEA:13500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-2-deoxy-D-gluconate + ATP <=> 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)
GO:0052868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-lysine lysyltransferase activity
RHEA:17444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-cysteine <=> 2-oxo-3-sulfanylpropanoate + L-glutamate
RHEA:11493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + O-phospho-L-threonine => (R)-1-aminopropan-2-yl phosphate + CO2
RHEA:53395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] <=> (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-4396401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants bind HES5 promoter (Homo sapiens)
RHEA:25368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) => H(+) + momilactone A + NADPH
RHEA:32604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-oxogeraniol + H(+) + NADPH
REACT:R-HSA-8878237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter (Homo sapiens)
REACT:R-HSA-444647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3a receptor binds anaphylatoxin C3a (Homo sapiens)
REACT:R-GGA-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Gallus gallus)
REACT:R-DRE-5661122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates Me2R3-histone H3 (Danio rerio)
RHEA:37248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thymidine 3'-monophosphate => phosphate + thymidine
RHEA:17758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-methionine => 3-(methylsulfanyl)propanamine + CO2
RHEA:11986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + testosterone acetate => AH2 + O2 + progesterone
REACT:R-HSA-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Homo sapiens)
RHEA:60377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) => D-glucose(in)
REACT:R-HSA-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Homo sapiens)
RHEA:38328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol
RHEA:64950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCDP + H(+) + phosphate => dCTP + H2O
RHEA:59857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium => methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine
RHEA:36575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + sphinganine = CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine
REACT:R-RNO-70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine => urocanate + NH4+ (Rattus norvegicus)
RHEA:35035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) = 4-aminobutanoate(out)
EC:5.6.2.-	skos:prefLabel	"Enzymes altering nucleic acid conformation"
EC:5.6.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Enzymes altering nucleic acid conformation"
REACT:R-DRE-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Danio rerio)
RHEA:52951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + UDP-alpha-D-glucuronate <=> deoxycholoyl-24-O-(beta-D-glucuronate) + UDP
REACT:R-RNO-936960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Rattus norvegicus)
REACT:R-GGA-3899291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of EP300 with SUMO1 (Gallus gallus)
REACT:R-RNO-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Rattus norvegicus)
REACT:R-MMU-193780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Mus musculus)
REACT:R-HSA-3928616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ROCK phosphorylates MRLCs (Homo sapiens)
REACT:R-RNO-205008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF binds to p62 (Sequestosome) (Rattus norvegicus)
REACT:R-SSC-183002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Sus scrofa)
REACT:R-DME-196372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Drosophila melanogaster)
RHEA:64435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-L-prolylglycine(out) <=> H(+)(in) + L-alanyl-L-prolylglycine(in)
REACT:R-HSA-2066788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Homo sapiens)
RHEA:30966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,9,9'-tri-cis-neurosporene + a quinone <=> 7,7',9,9'-tetra-cis-lycopene + a quinol
RHEA:23831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH
RHEA:36394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + NADP(+) <=> desmosterol + H(+) + NADPH
RHEA:27872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+) => (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O
REACT:R-GGA-8865613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Gallus gallus)
REACT:R-BTA-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Bos taurus)
RHEA:35538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-phenylalanyl-L-leucyl) + O2 <=> cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2
REACT:R-MMU-5685319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex formation (Mus musculus)
GO:0033711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	erythronate-4-phosphate dehydrogenase activity
GO:0033711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phosphoerythronate dehydrogenase activity
GO:0033711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PdxB
GO:0033711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity
GO:0033711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-O-phosphoerythronate dehydrogenase activity
GO:0033711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4PE dehydrogenase activity
GO:0033711	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PdxB 4PE dehydrogenase activity
REACT:R-HSA-560510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of FABP4 (aP2) (Homo sapiens)
RHEA:63096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ilicicolin A epoxide = ilicicolin C
RHEA:32115	skos:prefLabel	"2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase"
RHEA:32115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase"
RHEA:32115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + DIBOA beta-D-glucoside + O2 = CO2 + succinate + TRIBOA beta-D-glucoside
RHEA:32115	skos:altLabel	"DIBOA-Glc dioxygenase"
REACT:R-HSA-1013013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of GABA B receptor with G protein beta-gamma subunits (Homo sapiens)
REACT:R-DME-9615901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Drosophila melanogaster)
RHEA:39900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-deoxyloganetin + UDP-alpha-D-glucose => 7-deoxyloganin + H(+) + UDP
REACT:R-DRE-140851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Danio rerio)
RHEA:24537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 => N-formyl-L-kynurenine
EC:1.15.1.-	skos:prefLabel	"Acting on superoxide as acceptor"
EC:1.15.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on superoxide as acceptor"
REACT:R-CFA-428752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:Gq complex (Canis familiaris)
REACT:R-RNO-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Rattus norvegicus)
RHEA:43122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + succinate + urate => 2-oxoglutarate + O2 + xanthine
REACT:R-HSA-174122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Homo sapiens)
RHEA:19087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose
RHEA:59682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltopentaono-1,5-lactone + H2O2 => D-maltopentaose + O2
REACT:R-GGA-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Gallus gallus)
REACT:R-HSA-425678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)
RHEA:62085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glucosamine => AMP + D-glucosamine 6-phosphate + H(+)
RHEA:38603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
REACT:R-BTA-8848658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Bos taurus)
REACT:R-SSC-178208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF2 (Sus scrofa)
RHEA:71324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-asparagine(out) + 2 Na(+)(out) => chloride(in) + L-asparagine(in) + 2 Na(+)(in)
RHEA:39298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O
RHEA:19518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N-dimethylformamide => dimethylamine + formate
REACT:R-HSA-5649705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)
REACT:R-DRE-8849032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS2 (Danio rerio)
RHEA:45678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)
RHEA:13736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an n-alkanal + NAD(+) <=> an alk-2-enal + H(+) + NADH
REACT:R-DRE-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Danio rerio)
RHEA:45669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-DME-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Drosophila melanogaster)
REACT:R-BTA-9691421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK binds BTK inhibitors (Bos taurus)
REACT:R-HSA-442725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKII binds activated calmodulin (Homo sapiens)
RHEA:10432	skos:prefLabel	"2-(acetamidomethylene)succinate hydrolase"
RHEA:10432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-(acetamidomethylene)succinate hydrolase"
RHEA:10432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(acetamidomethylene)succinate + H(+) + 2 H2O = acetate + CO2 + NH4(+) + succinate semialdehyde
RHEA:12816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate <=> D-glutamate
REACT:R-SSC-111253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Sus scrofa)
RHEA:45338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA => (9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine
REACT:R-MMU-2161948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Mus musculus)
RHEA:42144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine
REACT:R-SSC-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Sus scrofa)
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-prolyl cis-trans isomerase activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-trans proline isomerase activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPIase activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidylprolyl cis-trans isomerase activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	juglone-sensitive cis-trans proline isomerase activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	FK506-sensitive peptidyl-prolyl cis-trans isomerase
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide bond isomerase activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	parvulin
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidyl-prolyl isomerase B reaction
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclophilin activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rotamase activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidylprolyl isomerase activity
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	immunophilin
GO:0003755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptidylproline cis-trans-isomerase activity
RHEA:66582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+) => 3'-phosphoadenylyl sulfate + bisphenol A
REACT:R-HSA-9749487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates IKBIP gene expression (Homo sapiens)
RHEA:37157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA
REACT:R-DDI-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Dictyostelium discoideum)
RHEA:43773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine
EC:5.5.1.24	skos:prefLabel	"tocopherol cyclase"
EC:5.5.1.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tocopherol cyclase"
REACT:R-MMU-8950778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dimerizes (Mus musculus)
REACT:R-SPO-70724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Schizosaccharomyces pombe)
REACT:R-HSA-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Homo sapiens)
REACT:R-HSA-8851890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates SHC1-2 (Homo sapiens)
REACT:R-MMU-390663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA2A,B,C bind ADR,NAd (Mus musculus)
REACT:R-CFA-2453855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)
RHEA:57503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O
RHEA:56459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-fischerindole U
RHEA:32236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADPHX + ADP => AMP + H(+) + NADPH + phosphate
RHEA:61801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-alanine => AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]
GO:0050429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent phospholipase C activity
REACT:R-HSA-3790130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of IL6 transcription (Homo sapiens)
RHEA:22669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + lipid A disaccharide (E. coli) + UDP
RHEA:51156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Gln)
REACT:R-XTR-2032775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD1 (Xenopus tropicalis)
REACT:R-SSC-2396599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of GRB2:SOS to p-5Y-LAT (Sus scrofa)
RHEA:66088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + oxaloacetate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate
RHEA:72650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine + NADPH + O2 <=> 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)
GO:0032036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin heavy chain binding
RHEA:12671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate => H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]
RHEA:25233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate
RHEA:25233	skos:altLabel	"sialic acid epimerase"
RHEA:25233	skos:altLabel	"alpha-N-acetylneuraminic acid epimerase"
RHEA:25233	skos:prefLabel	"N-acetylneuraminate epimerase"
RHEA:25233	skos:altLabel	"sialic acid mutarotase"
RHEA:25233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylneuraminate epimerase"
RHEA:33028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one
REACT:R-DDI-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)
EC:3.4.21.102	skos:prefLabel	"C-terminal processing peptidase"
EC:3.4.21.102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"C-terminal processing peptidase"
EC:3.4.21.102	skos:altLabel	"photosystem II D1 protein processing peptidase"
EC:3.4.21.102	skos:altLabel	"tail-specific protease"
EC:3.4.21.102	skos:altLabel	"protease Re"
EC:3.4.21.102	skos:altLabel	"Tsp protease"
REACT:R-SSC-508040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Sus scrofa)
GO:0031626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-endorphin binding
REACT:R-DRE-76453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A6 (Danio rerio)
REACT:R-CFA-6797630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRPP4(LRPP1-3,5) hydrolyse LPA (Canis familiaris)
RHEA:49440	skos:prefLabel	"(R)-2-hydroxy-4-methylpentanoate CoA-transferase"
RHEA:49440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-2-hydroxy-4-methylpentanoate CoA-transferase"
RHEA:49440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA = (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate
REACT:R-SSC-195690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Sus scrofa)
REACT:R-SPO-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Schizosaccharomyces pombe)
RHEA:14326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxycoumarin + UDP-alpha-D-glucose => daphnin + H(+) + UDP
REACT:R-XTR-1295599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 translocates to the plasma membrane (Xenopus tropicalis)
REACT:R-DDI-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)
EC:6.5.1.6	skos:prefLabel	"DNA ligase (ATP or NAD(+))"
EC:6.5.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA ligase (ATP or NAD(+))"
REACT:R-MMU-8865482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KMT2A (MLL) binds RUNX1 (Mus musculus)
REACT:R-XTR-9714959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to TNF(1-233) trimer (Xenopus tropicalis)
REACT:R-MMU-5669097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA trimer binds TNFRSF1A,1B,14 (Mus musculus)
REACT:R-RNO-453338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Rattus norvegicus)
RHEA:16466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + 2 Fe(III)-[cytochrome c553] => 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate
REACT:R-MMU-8869694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds CD14 (Mus musculus)
REACT:R-SSC-209903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenaline is converted to adrenaline (Sus scrofa)
RHEA:51146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2
REACT:R-HSA-9694280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA4 is translated to protein E (Homo sapiens)
REACT:R-GGA-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Gallus gallus)
REACT:R-DRE-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Danio rerio)
RHEA:44041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
GO:0072585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthosine nucleotidase activity
GO:0072585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthosine ribohydrolase activity
GO:0072585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + xanthosine = D-ribose + xanthine
REACT:R-RNO-416639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Rattus norvegicus)
REACT:R-RNO-164620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Rattus norvegicus)
RHEA:24306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+)
RHEA:14668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanine + H(+) + H2O <=> NH4(+) + xanthine
REACT:R-HSA-9627089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP9 is phosphorylated at T125 (Homo sapiens)
REACT:R-BTA-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Bos taurus)
REACT:R-RNO-8876191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB9 GEFs exchange GTP for GDP on RAB9 (Rattus norvegicus)
REACT:R-CEL-2066779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Caenorhabditis elegans)
RHEA:27486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + 2 H(+) + H2O => (S)-2-ureidoglycine + CO2 + NH4(+)
REACT:R-CFA-927830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Canis familiaris)
REACT:R-SPO-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Schizosaccharomyces pombe)
GO:0016773	skos:prefLabel	"Phosphotransferases with an alcohol group as acceptor"
GO:0016773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphotransferase activity, alcohol group as acceptor
GO:0016773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + AMP => abacavir monophosphate + adenosine (Homo sapiens)
GO:0016773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphotransferases with an alcohol group as acceptor"
REACT:R-RNO-209815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is monoiodinated (Rattus norvegicus)
REACT:R-SPO-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Schizosaccharomyces pombe)
REACT:R-SSC-9627350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) binds XIAP (Sus scrofa)
RHEA:22038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n-1) + D-glucose 6-phosphate + H(+) => [phosphate](n) + D-glucose
REACT:R-RNO-5607725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Rattus norvegicus)
GO:0001566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-kinase phorbol ester receptor activity
REACT:R-GGA-8982162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Gallus gallus)
REACT:R-CEL-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)
RHEA:43927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pregnenolone <=> H(+) + NADH + pregn-5-ene-3,20-dione
REACT:R-MMU-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Mus musculus)
REACT:R-HSA-8949343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB (Homo sapiens)
REACT:R-HSA-1912394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 in complex with RBPJ (CSL) recruits MAML (Homo sapiens)
REACT:R-CEL-9609921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds Tail-anchored protein (Caenorhabditis elegans)
RHEA:66872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:21883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + oxalate <=> 2 CO2 + H2O2
REACT:R-DRE-378956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Luteinizing hormone is a heterodimer (Danio rerio)
RHEA:12424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"threo-3-hydroxy-L-aspartate ammonia-lyase"
RHEA:12424	skos:altLabel	"L-threo-3-hydroxyaspartate dehydratase"
RHEA:12424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate
RHEA:12424	skos:altLabel	"threo-3-hydroxyaspartate dehydratase"
RHEA:12424	skos:prefLabel	"threo-3-hydroxy-L-aspartate ammonia-lyase"
REACT:R-PFA-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Plasmodium falciparum)
REACT:R-SSC-450222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Sus scrofa)
RHEA:30542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitinyl-CoA <=> (S)-carnitinyl-CoA
RHEA:56537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA
RHEA:44358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl nogalonate => nogalaviketone
REACT:R-SPO-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Schizosaccharomyces pombe)
REACT:R-XTR-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Xenopus tropicalis)
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-F synthetase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGD2 11-ketoreductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-D2 11-ketoreductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGD(2) 11-ketoreductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin-F synthase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-D(2) 11-reductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin D2-ketoreductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-D2 ketoreductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-D(2) 11-ketoreductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin F synthase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin F synthetase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-D(2) ketoreductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-dependent prostaglandin D2 11-keto reductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin 11-keto reductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reductase, 15-hydroxy-11-oxoprostaglandin
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin-D2 11-reductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGF synthetase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin 11-ketoreductase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PGF2alpha synthetase activity
GO:0047017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	synthetase, prostaglandin F2alpha
REACT:R-RNO-2028629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Rattus norvegicus)
RHEA:29884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-ornithine(out) => ADP + H(+) + L-ornithine(in) + phosphate
REACT:R-DDI-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Dictyostelium discoideum)
REACT:R-CFA-8936849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHR:2xHSP90:AIP:PTGES3 binds TCDD (Canis familiaris)
REACT:R-GGA-5340214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB binds O2 (Gallus gallus)
REACT:R-GGA-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Gallus gallus)
GO:0052819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heteroglycan 2-alpha-mannosyltransferase activity
GO:0052819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP mannose 2-alpha-mannosyltransferase activity
GO:0052819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heteropolysaccharide 2-alpha-mannosyltransferase activity
GO:0052819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose-heteroglycan 2-alpha-mannosyltransferase activity
GO:0052819	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:heteroglycan 2-alpha-D-mannosyltransferase activity
REACT:R-SSC-8953499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPAD1 hydrolyses PAP to AMP (Sus scrofa)
RHEA:44965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-dodecenoyl-CoA + H(+) + NADPH => dodecanoyl-CoA + NADP(+)
REACT:R-CEL-3149518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
REACT:R-MMU-8854462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR binds VLDL (Mus musculus)
RHEA:11803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) <=> AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)
REACT:R-SSC-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)
REACT:R-GGA-265429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Gallus gallus)
REACT:R-RNO-8870332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Rattus norvegicus)
RHEA:10655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + H2O + NAD(+) <=> a long-chain fatty acid + 2 H(+) + NADH
GO:0102166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity
REACT:R-BTA-9603986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 chains to form LeA (Bos taurus)
RHEA:11332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"polynucleotide adenylyltransferase"
RHEA:11332	skos:altLabel	"NTP polymerase"
RHEA:11332	skos:prefLabel	"polynucleotide adenylyltransferase"
RHEA:11332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide
RHEA:11332	skos:altLabel	"poly(A) polymerase"
RHEA:11332	skos:altLabel	"RNA adenylating enzyme"
REACT:R-RNO-5624486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylates RAF1 on Y340,Y341 (Rattus norvegicus)
REACT:R-CFA-9619756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2 binds ABCA1 (Canis familiaris)
REACT:R-SSC-1855208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Sus scrofa)
REACT:R-CEL-176054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers conjugate GSH with cytosolic substrates (Caenorhabditis elegans)
REACT:R-CEL-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Caenorhabditis elegans)
REACT:R-RNO-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Rattus norvegicus)
RHEA:63478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-oxoprostaglandin E2 + H(+) + NADPH => NADP(+) + prostaglandin E2
RHEA:44405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-7 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-7
REACT:R-SCE-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Saccharomyces cerevisiae)
RHEA:63740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetaldehyde + H(+) + NADH = 2-phenylethanol + NAD(+)
REACT:R-DRE-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Danio rerio)
REACT:R-GGA-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Gallus gallus)
RHEA:67816	skos:altLabel	"UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase"
RHEA:67816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate
RHEA:67816	skos:altLabel	"UDP-3-O-acyl-GlcNAc deacetylase"
RHEA:67816	skos:prefLabel	"UDP-3-O-acyl-N-acetylglucosamine deacetylase"
RHEA:67816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-3-O-acyl-N-acetylglucosamine deacetylase"
RHEA:67816	skos:altLabel	"UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase"
REACT:R-XTR-5654709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
RHEA:33594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinganine
RHEA:20263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + CoA + olivetol => 3,5,7-trioxododecanoyl-CoA
RHEA:62918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine
RHEA:53874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-D-ribose + diphosphate => CTP + D-ribose 5-phosphate + H(+)
RHEA:37635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:13967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + NH4(+) + pyruvate => H2O + L,L-cystathionine
REACT:R-GGA-8950423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Gallus gallus)
REACT:R-GGA-6784598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPPA(124-151) binds NPR1 (Gallus gallus)
REACT:R-CFA-9760081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP, EP300 acetylates NFE2L2 (Canis familiaris)
REACT:R-HSA-8866857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
EC:3.4.24.85	skos:altLabel	"sterol-regulatory element-binding proteins intramembrane protease"
EC:3.4.24.85	skos:altLabel	"membrane-bound transcription factor site 2 protease"
EC:3.4.24.85	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S2P endopeptidase"
EC:3.4.24.85	skos:altLabel	"site-2 protease"
EC:3.4.24.85	skos:prefLabel	"S2P endopeptidase"
REACT:R-XTR-8956458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNLS:FAD oxidises dh-beta-NAD to NAD+ (Xenopus tropicalis)
RHEA:57660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-72663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	De novo formation of eIF2:GTP (Drosophila melanogaster)
REACT:R-MMU-8951644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of mature NEDD8 (Mus musculus)
REACT:R-CFA-8952039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)
RHEA:20883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxydecanoate + NAD(+) <=> 10-oxodecanoate + H(+) + NADH
REACT:R-GGA-265887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of RPA heterotrimer to 3' double stranded DNA break (Gallus gallus)
REACT:R-BTA-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Bos taurus)
RHEA:57139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine
REACT:R-XTR-420173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR1,CRHR2-1 binds CRH,UCN (Xenopus tropicalis)
REACT:R-RNO-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Rattus norvegicus)
RHEA:68418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-iso(homo)2citrate => cis-(homo)2aconitate + H2O
RHEA:13749	skos:prefLabel	"nucleoside-triphosphate--adenylate kinase"
RHEA:13749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP
RHEA:13749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside-triphosphate--adenylate kinase"
REACT:R-HSA-3858506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GYS2 does not transfer glucose to growing glycogen chains (Homo sapiens)
RHEA:32526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nigerose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose
REACT:R-XTR-9749215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM8 binds CDC6 (Xenopus tropicalis)
RHEA:27851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + phenylacetyl-CoA => CoA + H(+) + phenylacetylglycine
RHEA:10585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)
REACT:R-DRE-8948034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds LDL:LRP8 (Danio rerio)
GO:0090591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity
GO:0052586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor
GO:0052586	skos:prefLabel	"With a quinone or similar compound as acceptor"
GO:0052586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
RHEA:14554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate => 2-oxoglutarate + cephalosporin C
RHEA:54612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methylbutanoyl-CoA + O2 = 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate
REACT:R-DME-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Drosophila melanogaster)
REACT:R-XTR-193691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kB migrates to the nucleus and turns on transcription (Xenopus tropicalis)
GO:0032555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	purine ribonucleotide binding
RHEA:41918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexadecanoyl-[ACP] + malonyl-[ACP]
REACT:R-SCE-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Saccharomyces cerevisiae)
REACT:R-DRE-8936519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO2:FAD dimer reduces quinones to hydroquinones (Danio rerio)
REACT:R-HSA-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)
GO:0031403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Li+ ion binding
GO:0031403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithium ion binding
RHEA:11079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 3 H(+) + NADH + O2 <=> catechol + CO2 + NAD(+) + NH4(+)
REACT:R-SCE-73605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Saccharomyces cerevisiae)
REACT:R-XTR-5686440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81:EME1,EME2 cleaves D-loop (Xenopus tropicalis)
REACT:R-DRE-5223313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Danio rerio)
REACT:R-XTR-373075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Metabotropic glutamate receptors bind glutamate (Xenopus tropicalis)
REACT:R-PFA-9714580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A3 binds DRIs (Plasmodium falciparum)
REACT:R-CFA-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Canis familiaris)
REACT:R-MMU-5687640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Mus musculus)
REACT:R-RNO-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Rattus norvegicus)
REACT:R-RNO-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Rattus norvegicus)
REACT:R-DRE-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Danio rerio)
REACT:R-BTA-6801195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3 binds BNIP3L (Bos taurus)
REACT:R-GGA-194310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Gallus gallus)
REACT:R-DRE-8851919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 and GRB2 (Danio rerio)
REACT:R-DRE-5218836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2beta binds alphaVbeta3 (Danio rerio)
REACT:R-XTR-444572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zinc is an agonist of GPR39 (Xenopus tropicalis)
GO:0016170	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-15
GO:0016170	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-15 receptor ligand
GO:0016170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-15 receptor binding
REACT:R-DME-538824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP1 binds to phosphorylated TIM in complex with PER (Drosophila melanogaster)
REACT:R-MMU-112266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Mus musculus)
REACT:R-HSA-5667037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHPN2 binds RHOB:GTP (Homo sapiens)
REACT:R-DRE-163090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation Of The Telomeric Chromosome End (Danio rerio)
REACT:R-HSA-975861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex (Homo sapiens)
REACT:R-RNO-77303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Rattus norvegicus)
REACT:R-SSC-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)
REACT:R-SSC-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Sus scrofa)
REACT:R-RNO-209868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
REACT:R-XTR-446364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Migfilin interacts with VASP (Xenopus tropicalis)
RHEA:60850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]
RHEA:41041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA
REACT:R-MMU-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Mus musculus)
RHEA:51468	skos:prefLabel	"D-lactate dehydrogenase (quinone)"
RHEA:51468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-lactate dehydrogenase (quinone)"
RHEA:51468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + a quinone = a quinol + pyruvate
REACT:R-GGA-428918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:G13 complex (Gallus gallus)
RHEA:58837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-2161775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12 oxidises LTA4 to LXA4/B4 (Homo sapiens)
REACT:R-GGA-9759461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of hepatic cells (Gallus gallus)
REACT:R-GGA-6799981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP2 binds bacterial peptidoglycan (Gallus gallus)
RHEA:24998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:56181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2
RHEA:33285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxohexanoate + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + NADPH + O2
RHEA:52819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-CEL-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Caenorhabditis elegans)
RHEA:51428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(aminoalkyl)phosphonate N-acetyltransferase"
RHEA:51428	skos:prefLabel	"(aminoalkyl)phosphonate N-acetyltransferase"
RHEA:51428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + aminomethylphosphonate = 2-N-acetamidomethylphosphonate + CoA
RHEA:51428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + acetyl-CoA = (2-acetamidoethyl)phosphonate + CoA + H(+)
RHEA:41342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2
REACT:R-BTA-158721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Bos taurus)
REACT:R-DRE-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Danio rerio)
REACT:R-RNO-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
REACT:R-DME-204863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang2 (Drosophila melanogaster)
REACT:R-DRE-1793207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses C4S/C6S chains (Danio rerio)
RHEA:67152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] = L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]
RHEA:62395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	levoglucosan + NAD(+) <=> 3-dehydrolevoglucosan + H(+) + NADH
REACT:R-BTA-9024997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Bos taurus)
GO:0015663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide mononucleotide transmembrane transporter activity
GO:0015663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinamide ribonucleotide transmembrane transporter activity
GO:0015663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nicotinamide mononucleotide permease activity
RHEA:15433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + dimethylallyl diphosphate = diphosphate + sophoraflavanone B
RHEA:15433	skos:prefLabel	"naringenin 8-dimethylallyltransferase"
RHEA:15433	skos:altLabel	"N8DT"
RHEA:15433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"naringenin 8-dimethylallyltransferase"
REACT:R-HSA-3927886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NCOR2 with SUMO1 (Homo sapiens)
REACT:R-CFA-432952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP180 interacts intracellularly with plectin and integrin beta4 (Canis familiaris)
REACT:R-SSC-1678843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein translation regulator 4EHP (Sus scrofa)
RHEA:34128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + olivetolate => cannabigerolate + diphosphate
REACT:R-DME-5654647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
REACT:R-MMU-6800798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PIDDosome binds CASP2 (Mus musculus)
RHEA:54535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-oxoglutaryl)-L-cysteinylglycine <=> 2-oxoglutarate + L-cysteinylglycine
RHEA:42000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP
RHEA:51748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A = 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate
RHEA:20699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 superoxide <=> H2O2 + O2
RHEA:56587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-epoxypropane + H2O <=> propane-1,2-diol
REACT:R-BTA-77095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and binding of the mRNA cap by the cap-binding complex  (Bos taurus)
RHEA:65430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deamido-NAD(+)(out) + NAD(+)(in) => deamido-NAD(+)(in) + NAD(+)(out)
REACT:R-DRE-6801666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK2 phosphorylates CENPJ (Danio rerio)
REACT:R-GGA-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)
REACT:R-HSA-9729870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol (Homo sapiens)
RHEA:20295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH => 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+)
REACT:R-SSC-9691168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 translocates to the endoplasmic reticulum membrane (Sus scrofa)
RHEA:63185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + 2 O2 => H(+) + NAD(+) + 2 superoxide
RHEA:33410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + H(+) <=> diphosphate + glycyl-5'-AMP
REACT:R-DRE-182993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL) (Danio rerio)
REACT:R-BTA-452100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 bound to IL2 receptor is phosphorylated (Bos taurus)
RHEA:17039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-acetaldehyde + NADPH => indole-3-ethanol + NADP(+)
RHEA:14597	skos:altLabel	"CDP-diglyceride-choline O-phosphatidyltransferase"
RHEA:14597	skos:prefLabel	"phosphatidylcholine synthase"
RHEA:14597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylcholine synthase"
RHEA:14597	skos:altLabel	"PC synthase"
RHEA:14597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a CDP-1,2-diacyl-sn-glycerol + choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:10769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate
REACT:R-XTR-9014293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GDIs block activation of RAC2 (Xenopus tropicalis)
REACT:R-CFA-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Canis familiaris)
REACT:R-XTR-5358475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH6 ligates ammonium to diphthine-EEF2 (Xenopus tropicalis)
GO:0080061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetonitrile nitrilase activity
REACT:R-XTR-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Xenopus tropicalis)
RHEA:14086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate
RHEA:54115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> diphosphate + selina-4(15),7(11)-diene
RHEA:27561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-hexaprenyl diphosphate + 3 diphosphate => (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate
RHEA:26331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate => (8S)-8-amino-7-oxononanoate + L-lysine
REACT:R-GGA-201476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates R-Smad1/5/8 directly (Gallus gallus)
REACT:R-CEL-5665871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1 binds 26S proteasome (Caenorhabditis elegans)
REACT:R-DME-8987214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimerizes (Drosophila melanogaster)
REACT:R-GGA-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Gallus gallus)
REACT:R-BTA-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Bos taurus)
REACT:R-HSA-110212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTHL1 glycosylase mediated recognition and binding of dihydrouracil (Homo sapiens)
REACT:R-BTA-446701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4-activated IRAK1 autophosphorylates (Bos taurus)
REACT:R-SSC-2130731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of COPII vesicle (Sus scrofa)
GO:0102453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity
GO:0102453	skos:prefLabel	"anthocyanidin 3-O-glucoside 6''-O-acyltransferase"
GO:0102453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanidin 3-O-glucoside 6''-O-acyltransferase"
GO:0102453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)
RHEA:10349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-L-proline + ATP + 2 H2O => ADP + H(+) + L-glutamate + phosphate
REACT:R-SSC-2473151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDCA5 (Sororin) enables cohesion of sister centromeres (Sus scrofa)
RHEA:36323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH = (9Z)-octadecen-1-ol + CoA + 2 NADP(+)
RHEA:10360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H(+)
RHEA:10360	skos:prefLabel	"dihydrocoumarin hydrolase"
RHEA:10360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dihydrocoumarin hydrolase"
REACT:R-DRE-429441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK activation by SRC (Danio rerio)
RHEA:65934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine
RHEA:19588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + NAD(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADH
REACT:R-HSA-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Homo sapiens)
RHEA:64780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-benzyl-L-cysteine = 2-aminoprop-2-enoate + benzylthiol
RHEA:60247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]
REACT:R-BTA-2022399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Bos taurus)
GO:0002153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRA binding
GO:0002153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	steroid receptor RNA activator RNA binding
RHEA:33509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenal + phosphoethanolamine => sphing-4-enine 1-phosphate
REACT:R-RNO-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Rattus norvegicus)
REACT:R-MMU-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Mus musculus)
RHEA:19536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 H2O + N(2)-succinyl-L-arginine <=> CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)
REACT:R-XTR-9714483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the ER membrane (Xenopus tropicalis)
REACT:R-HSA-139908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of DLC2 by MAPK8 (Homo sapiens)
RHEA:62455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-glutamate <=> AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]
RHEA:21319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phorbol 12,13-dibutanoate <=> butanoate + H(+) + phorbol 13-butanoate
REACT:R-SCE-1008248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Saccharomyces cerevisiae)
RHEA:65609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + docosanoyl-CoA => CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine
REACT:R-SSC-3907292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Sus scrofa)
REACT:R-DRE-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Danio rerio)
RHEA:38476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine
RHEA:22937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamine 6-phosphate => acetate + D-glucosamine 6-phosphate
RHEA:38316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate => 3-hydroxybenzoate + pyruvate
RHEA:59280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparagine = D-asparagine
REACT:R-HSA-9021520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds WWP2 (Homo sapiens)
RHEA:32904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calciol + O2 + reduced [NADPH--hemoprotein reductase] => calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DME-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Drosophila melanogaster)
REACT:R-DME-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Drosophila melanogaster)
REACT:R-BTA-1855179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Bos taurus)
REACT:R-DRE-209821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylation of N-acetyl-5-HT to form melatonin (Danio rerio)
REACT:R-CFA-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)
REACT:R-GGA-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Gallus gallus)
REACT:R-HSA-5632738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDIT4 binds 14-3-3 dimer (Homo sapiens)
RHEA:69499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decan-1-ol + O2 <=> decanal + H2O2
REACT:R-SSC-2032781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds TEAD (Sus scrofa)
RHEA:26483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(37) in tRNA + dimethylallyl diphosphate => diphosphate + N(6)-dimethylallyladenosine(37) in tRNA
RHEA:65869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(1)-dihydrotestosterone + H2O => 1,17beta-dihydroxyandrostan-3-one
REACT:R-HSA-480520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SALL4 (Homo sapiens)
REACT:R-CEL-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Caenorhabditis elegans)
REACT:R-DRE-420584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Nectin 3 trans heterodimer interaction (Danio rerio)
RHEA:33555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + a fatty acid
REACT:R-XTR-8951498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Xenopus tropicalis)
RHEA:17426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NADP(+) + pyruvate => acetyl-CoA + CO2 + NADPH
REACT:R-DME-5419273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of GTP and dissociation of 28S and 39S subunits (Drosophila melanogaster)
EC:2.4.1.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucosyl-DNA beta-glucosyltransferase"
EC:2.4.1.28	skos:prefLabel	"glucosyl-DNA beta-glucosyltransferase"
RHEA:14642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanurate + H2O => biuret + CO2
REACT:R-RNO-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Rattus norvegicus)
RHEA:12023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monocarboxylic acid amide + H2O <=> a monocarboxylate + NH4(+)
RHEA:34912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-methionine(in) => D-methionine(out)
RHEA:12635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => benzoate + H(+) + NADH + O2
REACT:R-SSC-2682349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Sus scrofa)
REACT:R-DME-209134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ARM by CKIalpha (Drosophila melanogaster)
REACT:R-HSA-9638097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)
REACT:R-GGA-392051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Grb2 to pFAK:NCAM1 (Gallus gallus)
RHEA:21214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]
RHEA:35655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP = 3',3'-c-di-AMP + 2 diphosphate
RHEA:35655	skos:prefLabel	"diadenylate cyclase"
RHEA:35655	skos:altLabel	"cyclic-di-AMP synthase"
RHEA:35655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diadenylate cyclase"
RHEA:63636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain fatty acyl-AMP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + H(+)
RHEA:31575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-oxo-dGTP diphosphatase"
RHEA:31575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)
RHEA:31575	skos:altLabel	"7,8-dihydro-8-oxoguanine triphosphatase"
RHEA:31575	skos:altLabel	"7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase"
RHEA:31575	skos:prefLabel	"8-oxo-dGTP diphosphatase"
RHEA:31575	skos:altLabel	"8-oxo-dGTPase"
EC:3.4.-.-	skos:prefLabel	"Acting on peptide bonds (peptidases)"
EC:3.4.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on peptide bonds (peptidases)"
RHEA:12412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-phosphoglycerate phosphatase"
RHEA:12412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + H2O = (R)-glycerate + phosphate
RHEA:12412	skos:prefLabel	"3-phosphoglycerate phosphatase"
GO:0051879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hsp90 class protein binding
GO:0051879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hsp90 binding
GO:0051879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hsp90 protein binding
REACT:R-DDI-5682011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds ATG7 dimer (Dictyostelium discoideum)
RHEA:47320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate = 3-oxo-3-phenylpropanoate + L-glutamate
RHEA:42246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopentanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + propanoyl-CoA
RHEA:60380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dehydroascorbate(out) = L-dehydroascorbate(in)
RHEA:57699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(I)inamide-[corrinoid adenosyltransferase] <=> adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate
GO:0030305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparinase activity
GO:0030305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparanase activity
REACT:R-CEL-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
REACT:R-CEL-508473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Caenorhabditis elegans)
REACT:R-XTR-76386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 S-demethylates 6MMP (Xenopus tropicalis)
REACT:R-DME-5686578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates ABL1 (Drosophila melanogaster)
GO:0035244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine C-methylase activity
GO:0035244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-arginine C-methylase activity
GO:0035244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine C-methyltransferase activity
GO:0035244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl arginine C-methyltransferase activity
GO:0035244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-arginine C-methyltransferase activity
REACT:R-DDI-71802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Dictyostelium discoideum)
REACT:R-PFA-4090284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of HIPK2 with SUMO1 (Plasmodium falciparum)
REACT:R-CFA-68825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated geminin is degraded by the proteasome (Canis familiaris)
RHEA:66135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate
RHEA:58852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-oxogeraniol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH
RHEA:44188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA
RHEA:47758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine
RHEA:37888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + small RNA 3'-end nucleotide => H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide
RHEA:46139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminopyrrolnitrin + H(+) + NADPH + 2 O2 <=> 2 H2O + NADP(+) + pyrrolnitrin
RHEA:15663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA => (E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside
REACT:R-CFA-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Canis familiaris)
RHEA:28741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(out) + H(+)(in) => Cd(2+)(in) + H(+)(out)
REACT:R-XTR-5357429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL autophosphorylates on Y772 and Y814 (Xenopus tropicalis)
RHEA:29921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP
RHEA:63266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2
REACT:R-DME-1237096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribose-P = Methylthio-ribulose-P (Drosophila melanogaster)
RHEA:22509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) => diphosphate + DNA(n+1)
RHEA:72172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + taurohyocholate(out) => 2 Na(+)(in) + taurohyocholate(in)
REACT:R-BTA-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Bos taurus)
REACT:R-SSC-3322009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Sus scrofa)
RHEA:60874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O
GO:0047792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanohydrin b-glucosyltransferase activity
GO:0047792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity
GO:0047792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity
GO:0047792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-cyanohydrin glucosyltransferase activity
GO:0047792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanohydrin beta-glucosyltransferase activity
GO:0047792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity
GO:0047792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity
GO:0047792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity
GO:0047792	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity
GO:0047792	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UGT85B1 activity
REACT:R-DRE-5654669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Danio rerio)
REACT:R-SSC-5654584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS bind to PPTN11 (Sus scrofa)
RHEA:67132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH = (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)
RHEA:51074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phenol + an aryl sulfate => a phenol + an aryl sulfate
REACT:R-HSA-6784006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)
REACT:R-RNO-2454240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to p-FCERI gamma subunit (Rattus norvegicus)
REACT:R-HSA-351901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MST3 (Homo sapiens)
RHEA:14127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1(F)-alpha-D-galactosylraffinose + sucrose => 2 raffinose
REACT:R-RNO-4086088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO1 (Rattus norvegicus)
RHEA:71039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) + L-phenylalanine(out) = L-methionine(out) + L-phenylalanine(in)
REACT:R-BTA-446191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Bos taurus)
REACT:R-DRE-997314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of JAK1 by SHP1 (Danio rerio)
REACT:R-DRE-444691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prokineticin receptors bind prokineticin (Danio rerio)
RHEA:59872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP
RHEA:46191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aliphatic nitrile + 2 H2O <=> a carboxylate + NH4(+)
REACT:R-CEL-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
REACT:R-PFA-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Plasmodium falciparum)
REACT:R-HSA-9621289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PINK1 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
RHEA:32981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + sn-glycero-3-phospho-L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O
RHEA:64092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)
REACT:R-DRE-8941234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Danio rerio)
RHEA:52791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a + 2 H(+) <=> Mg(2+) + pheophytin a
REACT:R-DRE-140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequestered tissue factor -> tissue factor (Danio rerio)
REACT:R-MMU-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Mus musculus)
RHEA:12697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dGMP = ADP + dGDP
REACT:R-CFA-5675868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates ATG13 and RB1CC1 (Canis familiaris)
RHEA:23568	skos:altLabel	"trans-2-decenoyl-ACP isomerase"
RHEA:23568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]
RHEA:23568	skos:altLabel	"beta-hydroxydecanoyl thioester dehydrase"
RHEA:23568	skos:prefLabel	"trans-2-decenoyl-[acyl-carrier-protein] isomerase"
RHEA:23568	skos:altLabel	"trans-2,cis-3-decenoyl-ACP isomerase"
RHEA:23568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-2-decenoyl-[acyl-carrier-protein] isomerase"
EC:7.4.2.4	skos:prefLabel	"chloroplast protein-transporting ATPase"
EC:7.4.2.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chloroplast protein-transporting ATPase"
REACT:R-HSA-1181153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Homo sapiens)
RHEA:55473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0047423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methylhydantoinase (ATP-hydrolysing)
GO:0047423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methylhydantoin amidohydrolase activity
GO:0047423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methylhydantoinase activity
GO:0047423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)
GO:0047423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylhydantoin amidase activity
GO:0047423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-methylhydantoinase (ATP-hydrolyzing) activity
GO:0047423	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methylhydantoin hydrolase activity
RHEA:64497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,7,9,11-pentaoxododecanoyl-[ACP] => 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]
REACT:R-HSA-76472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ethylene is oxidized to Ethylene oxide by CYP1A1 (Homo sapiens)
REACT:R-CFA-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Canis familiaris)
RHEA:35029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + tungstate(out) => ATP + H2O + tungstate(in)
RHEA:20241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate + S-adenosyl-L-methionine = N-methylnicotinate + S-adenosyl-L-homocysteine
RHEA:20241	skos:prefLabel	"nicotinate N-methyltransferase"
RHEA:20241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinate N-methyltransferase"
REACT:R-RNO-2142859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growing HA is extruded from the cell by ABCC5 (Rattus norvegicus)
RHEA:54534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-cysteinylglycine => H2O + N-(4-oxoglutaryl)-L-cysteinylglycine
REACT:R-CFA-5651739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Canis familiaris)
REACT:R-RNO-2752115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds CD44 (Rattus norvegicus)
REACT:R-BTA-110375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Bos taurus)
REACT:R-CEL-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Caenorhabditis elegans)
REACT:R-RNO-9717206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Rattus norvegicus)
REACT:R-XTR-8874745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Xenopus tropicalis)
RHEA:23115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylsalicylate + H(+) <=> 3-methylphenol + CO2
RHEA:36427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine
REACT:R-XTR-77309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Xenopus tropicalis)
GO:0102027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity
RHEA:54096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-SSC-3209165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ID1 sequesters ETS2 (Sus scrofa)
RHEA:34231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-nitrosalicylate + O2 = 4-nitro-6-oxohepta-2,4-dienedioate + H(+)
REACT:R-HSA-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Homo sapiens)
RHEA:65227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol
REACT:R-RNO-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Rattus norvegicus)
REACT:R-DRE-5205824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Danio rerio)
REACT:R-BTA-2562564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 processing within TLR4 complex (Bos taurus)
RHEA:70528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-acyl-3-oxosphinganine + NADH => an N-acylsphinganine + NAD(+)
REACT:R-SSC-2029467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by CRKII:DOCK180:ELMO (Sus scrofa)
RHEA:55756	skos:prefLabel	"ornithine lipid ester-linked acyl 2-hydroxylase"
RHEA:55756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ornithine lipid ester-linked acyl 2-hydroxylase"
RHEA:55756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 = a 2-hydroxyornithine lipid + CO2 + succinate
REACT:R-MMU-264679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serum albumin binds 2-lysophosphatidylcholine (Mus musculus)
RHEA:39376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O
RHEA:66263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + IC-asc-C7-AMP <=> AMP + H(+) + IC-asc-C7-CoA
REACT:R-MMU-194083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Mus musculus)
GO:0047466	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	chlorodienelactone isomerase activity
GO:0047466	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-chlorocarboxymethylenebutenolide isomerase activity
GO:0047466	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity
GO:0047466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity
RHEA:56420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[D-alanyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]
REACT:R-SSC-8871373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMX phosphorylates RUFY1 (Sus scrofa)
REACT:R-DME-75016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of p-S216-CDC25C with 14-3-3 proteins (Drosophila melanogaster)
REACT:R-HSA-9034016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTF3 binds NTRK3 (Homo sapiens)
REACT:R-RNO-192335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Rattus norvegicus)
REACT:R-DRE-6809006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Danio rerio)
REACT:R-SSC-5696914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP28 deubiquitinates CLSPN and MYC (Sus scrofa)
RHEA:69654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cumene hydroperoxide + 2 glutathione <=> 2-phenylpropan-2-ol + glutathione disulfide + H2O
REACT:R-BTA-482770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet secretory granule components (Bos taurus)
REACT:R-CFA-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Canis familiaris)
RHEA:15285	skos:altLabel	"adenylate isopentenyltransferase"
RHEA:15285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate
RHEA:15285	skos:altLabel	"cytokinin synthase"
RHEA:15285	skos:altLabel	"isopentenyltransferase"
RHEA:15285	skos:prefLabel	"adenylate dimethylallyltransferase (AMP-dependent)"
RHEA:15285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenylate dimethylallyltransferase (AMP-dependent)"
RHEA:21829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-5682992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4A,B bind H4K20Me2 (Bos taurus)
REACT:R-SSC-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Sus scrofa)
RHEA:25681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + O-phospho-L-serine + tRNA(Cys) <=> AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)
RHEA:68156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + L-glutamate = diphosphate + N-geranyl-L-glutamate
REACT:R-CEL-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)
RHEA:37064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-SPO-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Schizosaccharomyces pombe)
RHEA:62591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) <=> 4-hydroxybenzyl alcohol + CO2
REACT:R-GGA-9015122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors bind Va:Xa (Gallus gallus)
RHEA:14332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O-phospho-L-serine <=> 3-phosphooxypyruvate + L-glutamate
REACT:R-DRE-5635102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR161 is internalized (Danio rerio)
RHEA:32419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R,4R)-neoisodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH
REACT:R-DDI-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Dictyostelium discoideum)
RHEA:61967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-749448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
REACT:R-HSA-5660753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA (Homo sapiens)
RHEA:21021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(1-carboxyvinyl)-3-phosphoshikimate => chorismate + phosphate
RHEA:34108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + H(+) + hexadecanoyl-CoA => 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA
REACT:R-BTA-8950504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL27 binds CRLF1 (Bos taurus)
REACT:R-BTA-201515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK recruits PI3K (Bos taurus)
RHEA:49809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + butan-1-ol => a quinol + butanal
GO:0034335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA negative supercoiling activity
GO:0034335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA-gyrase activity
GO:0034335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DNA gyrase activity
REACT:R-DRE-9603984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Danio rerio)
REACT:R-CEL-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Caenorhabditis elegans)
RHEA:40040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 L-glutamate + N-acetyl-L-aspartate => 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate
RHEA:50961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine
REACT:R-CFA-373339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Canis familiaris)
REACT:R-BTA-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Bos taurus)
REACT:R-DME-1247910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses CysGly (Drosophila melanogaster)
REACT:R-DRE-8851129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside diphosphates (Danio rerio)
RHEA:25861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O => 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)
RHEA:68379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + L-asparagine <=> 2-oxosuccinamate + glycine
REACT:R-SPO-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Schizosaccharomyces pombe)
REACT:R-SSC-8854897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Sus scrofa)
REACT:R-PFA-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Plasmodium falciparum)
REACT:R-BTA-204008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC31:SEC13 and v-SNARE recruitment (Bos taurus)
REACT:R-XTR-70870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECHS1 hydrates methacrylyl-CoA (Xenopus tropicalis)
REACT:R-GGA-5651657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)
REACT:R-BTA-8983063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Bos taurus)
EC:3.1.3.49	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[pyruvate kinase]-phosphatase"
EC:3.1.3.49	skos:prefLabel	"[pyruvate kinase]-phosphatase"
REACT:R-CFA-171122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL + LDLR => LDL:LDLR complex (Canis familiaris)
REACT:R-GGA-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Gallus gallus)
REACT:R-HSA-76466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4A11 12-hydroxylates DDCX (Homo sapiens)
REACT:R-CFA-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Canis familiaris)
REACT:R-MMU-909738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 bind the common beta chain (Mus musculus)
RHEA:36618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine
REACT:R-GGA-5250938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Gallus gallus)
REACT:R-BTA-9005995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the SIN3A co-repressor complex (Bos taurus)
GO:0043718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HgD
GO:0043718	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity
GO:0043718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxymethylglutarate dehydrogenase activity
REACT:R-CEL-193407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
GO:0030795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	jasmonic acid carboxyl methyltransferase activity
GO:0030795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity
GO:0030795	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:jasmonate O-methyltransferase activity
GO:0030795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl jasmonate methylesterase activity
RHEA:14486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => 10-epi-juneol + diphosphate
REACT:R-GGA-921155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from the receptor complex (Gallus gallus)
RHEA:71689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-aspartate(in) + 2 H(+)(in) => glycyl-L-aspartate(out) + 2 H(+)(out)
REACT:R-BTA-6799197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)
REACT:R-DME-70241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Drosophila melanogaster)
REACT:R-MMU-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Mus musculus)
REACT:R-SSC-8854071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome-mediated degradation of PolyUb-FBXL7 (Sus scrofa)
REACT:R-SSC-141439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of activated MAD2 from kinetochores (Sus scrofa)
REACT:R-CFA-193702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of the ICD migrates to the nucleus (Canis familiaris)
RHEA:10791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-gluconate + ATP <=> 6-phospho-2-dehydro-D-gluconate + ADP + H(+)
RHEA:45594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine
GO:0003712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcriptional co-regulator
GO:0003712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcriptional cofactor activity
GO:0003712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription coregulator activity
GO:0003712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription cofactor activity
RHEA:66406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathione(out) + H(+) + phosphate + taurocholate(out) => ATP + glutathione(in) + H2O + taurocholate(in)
GO:0047851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	omega-dicarboxylate:CoA ligase (AMP-forming)
GO:0047851	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxylyl-CoA synthetase activity
GO:0047851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dicarboxylate-CoA ligase activity
GO:0047851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dicarboxylate--CoA ligase"
GO:0047851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate + ATP + CoA = AMP + diphosphate + omega-dicarboxyl-CoA
GO:0047851	skos:prefLabel	"dicarboxylate--CoA ligase"
REACT:R-DDI-110224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine glycol by NTHL1 glycosylase   (Dictyostelium discoideum)
RHEA:29591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate + NADP(+) = H(+) + NADPH + sulfoacetaldehyde
RHEA:29591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfoacetaldehyde reductase (NADPH)"
RHEA:29591	skos:prefLabel	"sulfoacetaldehyde reductase (NADPH)"
REACT:R-MMU-8934446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC phosphorylates SHC1 (Mus musculus)
REACT:R-SSC-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Sus scrofa)
REACT:R-RNO-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Rattus norvegicus)
REACT:R-XTR-2562594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated OPTN translocates to the nucleus (Xenopus tropicalis)
RHEA:61050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase] => lochnericine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:29705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-valine(out) => L-valine(in)
REACT:R-CFA-6792871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNG1 recruits PP2A-PPP2R5C to MDM2 (Canis familiaris)
RHEA:23283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + cysteamine <=> CoA + S-acetylcysteamine
REACT:R-HSA-5693108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Homo sapiens)
RHEA:61797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP => AMP + L-tryptophyl-[peptidyl-carrier protein]
REACT:R-RNO-265153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Rattus norvegicus)
REACT:R-RNO-914182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)
REACT:R-GGA-382057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of novel PDGFs as latent factors (Gallus gallus)
RHEA:56576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer + H(+) + UDP
REACT:R-XTR-3249371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylates STAT6 at Ser407 (Xenopus tropicalis)
RHEA:35786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin B + UDP
REACT:R-HSA-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Homo sapiens)
REACT:R-CFA-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Canis familiaris)
REACT:R-DRE-183002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Danio rerio)
RHEA:10558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate => D-glyceraldehyde 3-phosphate + L-arginine
REACT:R-BTA-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Bos taurus)
REACT:R-RNO-2872498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Rattus norvegicus)
REACT:R-CEL-1676164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)
REACT:R-RNO-375151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with collagens (Rattus norvegicus)
REACT:R-DRE-9021072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHHC7, ZDHHC21 palmitoylate ESR1 (Danio rerio)
REACT:R-SSC-1112666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)
REACT:R-CEL-8874208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Caenorhabditis elegans)
RHEA:64116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine
RHEA:69072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + serotonin = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
REACT:R-GGA-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Gallus gallus)
RHEA:17679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+) => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O
GO:0102887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-sesquiphellandrene synthase activity
REACT:R-CEL-69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Dna2 endonuclease (Caenorhabditis elegans)
REACT:R-HSA-9613570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Homo sapiens)
RHEA:68294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-nonanoyl-L-seryl-[protein] => L-seryl-[protein] + nonanoyl-CoA
GO:0018471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzaldehyde oxidase activity
GO:0071917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triose-phosphate transmembrane transporter activity
REACT:R-RNO-1482850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Rattus norvegicus)
REACT:R-CFA-5625774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Canis familiaris)
RHEA:23934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine 6-phosphate => an N-acyl-D-glucosamine 6-phosphate
RHEA:10718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 3-phosphate => D-glucose 6-phosphate
REACT:R-RNO-9604767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 dimer autophosphorylates (Rattus norvegicus)
REACT:R-CFA-6781814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 deubiquitinates RNF123 (Canis familiaris)
GO:0052740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GO:0052740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
GO:0052740	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphatidylserine-specific phospholipase A1 activity
GO:0052740	skos:prefLabel	"phospholipase A1"
GO:0052740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phospholipase A1"
RHEA:25770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-carboxy-2-oxobutanoate + H(+) <=> 2-oxobutanoate + CO2
REACT:R-MMU-6798528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9 binds Mn2+ (Mus musculus)
RHEA:17891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NH4(+) + phosphate => H2O + phosphoethanolamine
REACT:R-DRE-5654422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds FRS2 (Danio rerio)
REACT:R-RNO-204813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb14 (Rattus norvegicus)
REACT:R-DRE-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Danio rerio)
RHEA:39995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylethanolamine + H2O = a fatty acid + ethanolamine
RHEA:67476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-glutamate = diphosphate + prekainate
RHEA:16159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[leghemoglobin] + H(+) + NADP(+) => 2 Fe(III)-[leghemoglobin] + NADPH
REACT:R-HSA-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Homo sapiens)
REACT:R-HSA-9731274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp16 localizes to the nucleus (Homo sapiens)
REACT:R-RNO-9624668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDKN1A (p21) (Rattus norvegicus)
RHEA:21734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + H(+) + L-glutamate + pyruvate => chorismate + L-glutamine
REACT:R-XTR-198955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR complex interacts with peptide antigen-presenting MHC Class I (Xenopus tropicalis)
REACT:R-HSA-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Homo sapiens)
RHEA:55380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3alpha-hydroxy bile acid CoA + NAD(+) = a 3-oxo bile acid CoA + H(+) + NADH
RHEA:18552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP
REACT:R-CEL-71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDO tetramer dioxygenates L-Trp to NFK (Caenorhabditis elegans)
REACT:R-SSC-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Sus scrofa)
REACT:R-MMU-1918095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL5 mediates ubiquitination of ERBB2 (Mus musculus)
RHEA:59776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + O2 = D-arabinose + H2O2
REACT:R-GGA-5685318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex formation (Gallus gallus)
REACT:R-DDI-2730868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK7 by MEKK1 (Dictyostelium discoideum)
REACT:R-PFA-984606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-5 is a homotetramer (Plasmodium falciparum)
REACT:R-MMU-5683385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of BRCA1-A complex at DNA DSBs (Mus musculus)
RHEA:22893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) => 5,10-methenyltetrahydrofolate + NADH
RHEA:69739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylsuccinate + succinyl-CoA = 3-phenylsuccinyl-CoA + succinate
REACT:R-SSC-5358525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Sus scrofa)
RHEA:44558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-hexaprenyl diphosphate
RHEA:72586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) <=> 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH
REACT:R-MMU-5684081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds CDK2 and RBBP8 (Mus musculus)
RHEA:45049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetamide + H2O => acetate + NH4(+)
RHEA:52910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dimethylallyl-4-hydroxymandelate + CO2 => 3-dimethylallyl-4-hydroxyphenylpyruvate + O2
REACT:R-CFA-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
REACT:R-DRE-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Danio rerio)
REACT:R-RNO-3640872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP34 deubiquitinates AXIN1,AXIN2 (Rattus norvegicus)
REACT:R-HSA-73792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)
RHEA:63344	skos:prefLabel	"oxazoline synthase"
RHEA:63344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-amino acyl-L-threonyl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate
RHEA:63344	skos:altLabel	"cyanobactin cyclodehydratase"
RHEA:63344	skos:altLabel	"cyanobactin heterocyclase"
RHEA:63344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxazoline synthase"
GO:0102836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity
REACT:R-BTA-1955380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIMM9:TIMM10 transfers proteins to TIMM22 (Bos taurus)
REACT:R-SCE-1299338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRESK (Saccharomyces cerevisiae)
REACT:R-MMU-8853755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Mus musculus)
RHEA:61349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + estrone 3-sulfate(in) + H2O => ADP + estrone 3-sulfate(out) + H(+) + phosphate
REACT:R-HSA-6799409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates TP53 (Homo sapiens)
REACT:R-BTA-109415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)
REACT:R-MMU-4093342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDC2 multimerises (Mus musculus)
REACT:R-SSC-9728723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Sus scrofa)
RHEA:47884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
RHEA:59329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,5-lactone + H2O => D-xylonate + H(+)
REACT:R-SCE-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Saccharomyces cerevisiae)
REACT:R-HSA-9606884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Homo sapiens)
RHEA:66757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + domoate(in) + H2O => ADP + domoate(out) + H(+) + phosphate
RHEA:30191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + plastoquinone-9 = 15,9'-di-cis-phytofluene + plastoquinol-9
REACT:R-CFA-9634702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Canis familiaris)
REACT:R-HSA-373717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacts with DIP13alpha (Homo sapiens)
RHEA:16246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-HSA-1592239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PEO1 (Homo sapiens)
GO:0043771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine kinase activity
RHEA:10703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + limonene 1,2-epoxide <=> limonene-1,2-diol
REACT:R-HSA-266328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Homo sapiens)
RHEA:39653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O
REACT:R-GGA-1307963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Gallus gallus)
REACT:R-XTR-170868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated type I receptor phosphorylates SMAD2/3 directly (Xenopus tropicalis)
RHEA:31725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:21060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,4-dichloroaniline N-malonyltransferase"
RHEA:21060	skos:prefLabel	"3,4-dichloroaniline N-malonyltransferase"
RHEA:21060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dichloroaniline + malonyl-CoA = CoA + N-(3,4-dichlorophenyl)malonamate
RHEA:55506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:51056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + androst-4-ene-3,17-dione = AH2 + androsta-1,4-diene-3,17-dione
REACT:R-HSA-2470508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin (Homo sapiens)
REACT:R-GGA-597628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Gallus gallus)
RHEA:11910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate + H(+) + pentan-2-one => H2O + nonane-4,6-dione
RHEA:66539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cholest-4,6-dien-3-one + H2O <=> 25-hydroxycholest-4,6-dien-3-one + AH2
RHEA:58559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate II + H2O <=> (16S)-deshydroxymethyl-stemmadenine + formate
REACT:R-DDI-381091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 dimer autophosphorylates (Dictyostelium discoideum)
REACT:R-SSC-5649734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates NEIL1,NEIL2-generated single strand break (Sus scrofa)
REACT:R-CFA-5610763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Canis familiaris)
GO:0098744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol 4-kinase activator activity
RHEA:67694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + hexadecanedioate(out) + phosphate => ATP + H2O + hexadecanedioate(in)
GO:0047412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(long-chain-acyl)ethanolamine amidohydrolase activity
GO:0047412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(long-chain-acyl)ethanolamine deacylase activity
GO:0047412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acylethanolamine amidase activity
GO:0047412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylethanolamine amidohydrolase activity
RHEA:48354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
REACT:R-DRE-8874082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates PTK2 (Danio rerio)
REACT:R-MMU-200555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Mus musculus)
REACT:R-BTA-194632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Bos taurus)
REACT:R-XTR-8851044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN1A1 binds xanthine oxidoreductase (XDH) (Xenopus tropicalis)
REACT:R-XTR-1433514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)
REACT:R-DDI-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Dictyostelium discoideum)
REACT:R-DME-6799196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Drosophila melanogaster)
REACT:R-SPO-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)
RHEA:48269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4',4'-dihydroxyechinenone => canthaxanthin + H2O
RHEA:71352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone 3alpha-sulfate(out) + 2 Na(+)(out) => androsterone 3alpha-sulfate(in) + 2 Na(+)(in)
RHEA:12069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]
REACT:R-MMU-183084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Mus musculus)
REACT:R-RNO-171087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR [endosome membrane] => LDLR [plasma membrane] (Rattus norvegicus)
GO:0010297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heteroglycan binding
GO:0010297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heteropolysaccharide binding
REACT:R-HSA-9734274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP (Homo sapiens)
RHEA:21078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + succinate + uridine => 2'-deoxyuridine + 2-oxoglutarate + O2
RHEA:39074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanedioyl-CoA + O2 <=> (2E)-dodecenedioyl-CoA + H2O2
REACT:R-DRE-4085029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU2 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)
RHEA:62530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrodigoxin + 2 Fe(III)-[cytochrome c] => digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+)
REACT:R-HSA-8847579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD5 desaturates ST-CoA to OLE-CoA (Homo sapiens)
REACT:R-HSA-1482545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)
RHEA:66476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenate + UDP-alpha-D-glucose = gypsogenate 28-beta-D-glucoside + UDP
RHEA:31853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	parkeol => (S)-2,3-epoxysqualene
REACT:R-CFA-204824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Ang4 (Canis familiaris)
REACT:R-SSC-9700701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T-type VDCC bind T-type VDCC blockers (Sus scrofa)
RHEA:52102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-octadecenoyloxy)-octadecanoate + H2O
REACT:R-CFA-8851888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds SHC1-2 (Canis familiaris)
REACT:R-DRE-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Danio rerio)
REACT:R-XTR-983266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins bind microtubules (Xenopus tropicalis)
RHEA:35679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H(+) + L-serine = 3-oxotetradecasphinganine + CO2 + CoA
RHEA:55121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)
REACT:R-MMU-444620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide S receptor binds neuropeptide S (Mus musculus)
RHEA:57173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH
RHEA:42184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH
REACT:R-RNO-201630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Acinus (Rattus norvegicus)
RHEA:25175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-citrulline + methylamine => H2O + N(omega)-methyl-L-arginine
REACT:R-RNO-111253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Rattus norvegicus)
RHEA:63781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine
RHEA:34302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyneamine + 2-oxoglutarate <=> 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate
RHEA:66420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)
GO:0004048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl-anthranilate diphosphorylase activity
GO:0004048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity
GO:0004048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity
GO:0004048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PRT
GO:0004048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyl-anthranilate pyrophosphorylase activity
GO:0004048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylanthranilate pyrophosphorylase activity
GO:0004048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity
GO:0004048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosylanthranilate transferase activity
GO:0004048	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilate-PP-ribose-P phosphoribosyltransferase activity
GO:0004048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate phosphoribosyltransferase activity
RHEA:66319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O <=> alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)
RHEA:45101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-demethylmitomycin B + S-adenosyl-L-methionine => mitomycin B + S-adenosyl-L-homocysteine
REACT:R-DDI-5691004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC binds RAD23 and CETN2 (Dictyostelium discoideum)
RHEA:68853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (1S,6S,7R)-sesquipiperitol + diphosphate
REACT:R-XTR-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Xenopus tropicalis)
GO:0015107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorate transmembrane transporter activity
REACT:R-DRE-194669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
RHEA:11219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + ATP <=> a 2'-deoxyribonucleoside 5'-diphosphate + ADP
REACT:R-CFA-354124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pPTK2 by SRC (Canis familiaris)
RHEA:66427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + leukotriene B4(in) <=> ADP + H(+) + leukotriene B4(out) + phosphate
RHEA:72213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-camphor + H(+) + NADH => (+)-isoborneol + NAD(+)
RHEA:22479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH
REACT:R-XTR-5246478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOM binds retinoids (Xenopus tropicalis)
RHEA:54359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + H(+) <=> 2-methylpropanal + CO2
RHEA:14360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + riboflavin <=> ADP + FMN + H(+)
REACT:R-MMU-997314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of JAK1 by SHP1 (Mus musculus)
REACT:R-CEL-442724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Caenorhabditis elegans)
REACT:R-DRE-8858500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC10A binds Tn-MUC1 (Danio rerio)
REACT:R-SSC-9693207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD translocates to the mitochondrial outer membrane (Sus scrofa)
REACT:R-RNO-389158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
EC:3.5.1.124	skos:prefLabel	"protein deglycase"
EC:3.5.1.124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein deglycase"
EC:3.5.1.124	skos:altLabel	"glyoxylase III"
REACT:R-BTA-8854628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLIP dimer ubiquitinates VLDLR on Lys-839 (Bos taurus)
RHEA:24712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose => 2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose
REACT:R-HSA-5655301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 mutants phosphorylate PLCG1 (Homo sapiens)
RHEA:18228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[N-(6-aminohexanoyl)](n) + H2O <=> 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)
REACT:R-PFA-1362408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Plasmodium falciparum)
REACT:R-BTA-975593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Bos taurus)
RHEA:63901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(4-hydroxyphenyl)pyruvate + H(+) => (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O
REACT:R-MMU-8853379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Mus musculus)
REACT:R-CEL-2404135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4 binds atROL (Caenorhabditis elegans)
REACT:R-BTA-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)
REACT:R-CFA-174444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C-strand Okazaki fragments (Canis familiaris)
REACT:R-RNO-449058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family are secreted (Rattus norvegicus)
REACT:R-HSA-158164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)
REACT:R-SSC-5690702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN phosphorylates CD22 (Sus scrofa)
REACT:R-HSA-5602004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP24A1 does not 24-hydroxylate CALTOL (Homo sapiens)
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	APRT activity
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylate pyrophosphorylase activity
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine phosphoribosyltransferase activity
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP-pyrophosphate phosphoribosyltransferase activity
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylic pyrophosphorylase activity
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transphosphoribosidase activity
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP:diphosphate phospho-D-ribosyltransferase activity
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP diphosphorylase activity
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenine phosphoribosylpyrophosphate transferase activity
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine phosphoribosyltransferase activity
GO:0003999	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AMP pyrophosphorylase activity
RHEA:36001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-BTA-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
GO:0004924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oncostatin-M receptor activity
GO:0051118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mutanase activity
GO:0051118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan endo-1,3-alpha-glucosidase activity
GO:0051118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cariogenase activity
GO:0051118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,3-alpha-D-glucanase activity
GO:0051118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-(1->3)-alpha-glucanase activity
GO:0051118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endo-1,3-alpha-glucanase activity
GO:0051118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cariogenanase activity
GO:0051118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity
REACT:R-CEL-73815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
RHEA:69865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in mRNA + S-adenosyl-L-methionine
REACT:R-CFA-196372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Canis familiaris)
REACT:R-RNO-9625814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates sphingosine in response to E2 stimulation (Rattus norvegicus)
REACT:R-SSC-981497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Sus scrofa)
RHEA:51221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
RHEA:56108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:14406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + NADP(+) => D-glucono-1,5-lactone + H(+) + NADPH
REACT:R-SSC-71335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Sus scrofa)
RHEA:60972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + NAD(+) = H(+) + hexanal + NADH
REACT:R-RNO-209924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is decarboxylated to dopamine (Rattus norvegicus)
REACT:R-CFA-1602417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Canis familiaris)
REACT:R-DME-174070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cdh1 with the APC/C (Drosophila melanogaster)
REACT:R-BTA-1112514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK activation (Bos taurus)
REACT:R-RNO-9731931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds selective ERAs (Rattus norvegicus)
REACT:R-CFA-2022381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)
RHEA:41779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) <=> CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)
GO:0102659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity
REACT:R-PFA-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)
REACT:R-HSA-9733969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts dissociate from FABP6 (Homo sapiens)
REACT:R-HSA-5692755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates MAPK6 (Homo sapiens)
REACT:R-DRE-9708557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 binds BACH1:MAFK (Danio rerio)
RHEA:36565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH => GDP-beta-L-colitose + NADP(+)
RHEA:25081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-isopropyl-3-oxosuccinate + H(+) <=> 4-methyl-2-oxopentanoate + CO2
REACT:R-HSA-9674532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP gene expression is positively regulated by VEGF (Homo sapiens)
REACT:R-GGA-9709842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAVS binds TOMM70 (Gallus gallus)
REACT:R-DRE-6803789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Danio rerio)
REACT:R-RNO-9634850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT (Rattus norvegicus)
RHEA:23649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-beta-L-talose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH
REACT:R-RNO-8853800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARTN binds RET:GFRA1,GFRA3 (Rattus norvegicus)
RHEA:56847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocamycin E + S-adenosyl-L-methionine <=> nocamycin I + S-adenosyl-L-homocysteine
REACT:R-CFA-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Canis familiaris)
REACT:R-XTR-4755419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1H4 with SUMO1 (Xenopus tropicalis)
GO:0090433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA synthetase activity
GO:0090433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA ligase activity
GO:0090433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Homo sapiens)
RHEA:11950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + CoA + H(+) => 4-hydroxybenzoyl-CoA + H2O
REACT:R-SSC-190429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c (Sus scrofa)
REACT:R-HSA-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Homo sapiens)
REACT:R-DME-9693478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A agonists (Drosophila melanogaster)
GO:0102217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phosphoglucan, water dikinase activity
RHEA:31638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc
RHEA:24698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol
RHEA:24698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol
RHEA:24698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Kdo2-lipid A phosphoethanolamine 7''-transferase"
RHEA:24698	skos:prefLabel	"Kdo2-lipid A phosphoethanolamine 7''-transferase"
REACT:R-SSC-8867658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates MAPK12 (Sus scrofa)
REACT:R-DRE-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Danio rerio)
REACT:R-CEL-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Caenorhabditis elegans)
RHEA:18130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoaldehyde + H2O + NADP(+) => a 2-oxocarboxylate + 2 H(+) + NADPH
REACT:R-CFA-5615637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Canis familiaris)
REACT:R-DME-110468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of DAkt1 by DPDK1 (Drosophila melanogaster)
REACT:R-HSA-8983680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAS1 produces oligoadenylates (Homo sapiens)
GO:0010298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocamalexic acid decarboxylase activity
GO:0010298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-428262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramide + H2O => stearate + phytosphingosine (Xenopus tropicalis)
REACT:R-XTR-5159250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF7IP binds SETDB1 (Xenopus tropicalis)
RHEA:52227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 3 H(+) + heme b + 3 O2 <=> 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O
REACT:R-DDI-5683792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 autophosphorylates (Dictyostelium discoideum)
REACT:R-SSC-9748969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Sus scrofa)
REACT:R-RNO-140769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VII -> factor VIIa (Rattus norvegicus)
REACT:R-HSA-72619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2:GTP is hydrolyzed, eIFs are released  (Homo sapiens)
REACT:R-CEL-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)
RHEA:21055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH
REACT:R-MMU-8875482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin to ubiquitinated MET (Mus musculus)
REACT:R-SSC-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Sus scrofa)
REACT:R-MMU-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Mus musculus)
RHEA:64260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + glycine = CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine
RHEA:31035	skos:prefLabel	"arabidiol synthase"
RHEA:31035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arabidiol synthase"
RHEA:31035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabidiol = (S)-2,3-epoxysqualene + H2O
RHEA:30962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9'-di-cis-zeta-carotene + a quinone <=> 7,9,9'-tri-cis-neurosporene + a quinol
REACT:R-RNO-380942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LKB1 forms a trimeric complex with STRAD and MO25 (Rattus norvegicus)
REACT:R-CFA-6809663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hair keratin fibres (Canis familiaris)
RHEA:20944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + theobromine = caffeine + H(+) + S-adenosyl-L-homocysteine
REACT:R-SCE-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Saccharomyces cerevisiae)
RHEA:10365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dodecanoyl-CoA + H2O => (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)
RHEA:11711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + IMP + NAD(+) <=> H(+) + NADH + XMP
RHEA:60263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine
REACT:R-GGA-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Gallus gallus)
REACT:R-DRE-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Danio rerio)
REACT:R-DDI-110360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to the AP site (Dictyostelium discoideum)
REACT:R-HSA-193647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK is activated (Homo sapiens)
RHEA:12941	skos:altLabel	"alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase"
RHEA:12941	skos:prefLabel	"alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"
RHEA:12941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"
RHEA:12941	skos:altLabel	"uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase"
RHEA:12941	skos:altLabel	"acetylglucosaminyltransferase II"
RHEA:12941	skos:altLabel	"uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase"
RHEA:12941	skos:altLabel	"GlcNAc-T II"
RHEA:12941	skos:altLabel	"uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase"
RHEA:12941	skos:altLabel	"N-acetylglucosaminyltransferase II"
RHEA:12941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:12941	skos:altLabel	"GnTII"
RHEA:12941	skos:altLabel	"N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II"
REACT:R-DRE-2076419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Danio rerio)
REACT:R-DRE-8869580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DEK binds TFAP2A homodimers (Danio rerio)
REACT:R-CFA-8850560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha releases G-protein heterotrimer from PDCL  (Canis familiaris)
RHEA:32851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
RHEA:24357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine
RHEA:10031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate + H2O + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)
RHEA:60409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine
REACT:R-SSC-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Sus scrofa)
REACT:R-RNO-5654423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)
REACT:R-HSA-3928610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates at Y397 (Homo sapiens)
RHEA:32237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + NADPH + phosphate => (6S)-NADPHX + ADP
RHEA:21468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-mycaminose + tylactone = 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)
RHEA:21468	skos:prefLabel	"tylactone mycaminosyltransferase"
RHEA:21468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tylactone mycaminosyltransferase"
RHEA:62328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2
RHEA:69061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 => H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)
REACT:R-HSA-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Homo sapiens)
REACT:R-SCE-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Saccharomyces cerevisiae)
REACT:R-SSC-5607726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Sus scrofa)
REACT:R-DME-9029551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Drosophila melanogaster)
RHEA:39423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA = (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O
REACT:R-RNO-8867667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Rattus norvegicus)
RHEA:31898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> alpha-humulene + diphosphate
RHEA:14923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP => (indol-3-yl)acetate + UDP-alpha-D-glucose
RHEA:35738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH
RHEA:11034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-cis,cis-muconate + H(+) => (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate
REACT:R-DME-265425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with von Willbrand Factor (Drosophila melanogaster)
RHEA:10304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]
RHEA:10304	skos:prefLabel	"acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase"
RHEA:10304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase"
REACT:R-HSA-4088281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endorepellin binds KDR (VEGFR2) (Homo sapiens)
REACT:R-XTR-2160915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor-mediated uptake of HA (Xenopus tropicalis)
GO:0140852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone ubiquitin ligase activity
RHEA:37770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-XTR-399939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Xenopus tropicalis)
REACT:R-GGA-5631885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX1 overoxidizes (Gallus gallus)
REACT:R-XTR-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Xenopus tropicalis)
REACT:R-HSA-210824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HNF6-dependent synthesis of HNF1B protein (Homo sapiens)
RHEA:63030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoate + NH4(+) => (15Z)-tetracosenamide + H2O
REACT:R-XTR-9658253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP binds PI3K (Xenopus tropicalis)
REACT:R-HSA-9734687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 is phosphorylated on T195 (Homo sapiens)
REACT:R-DME-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Drosophila melanogaster)
EC:1.1.1.94	skos:altLabel	"glycerol 3-phosphate dehydrogenase (NAD(P))"
EC:1.1.1.94	skos:prefLabel	"glycerol-3-phosphate dehydrogenase [NAD(P)(+)]"
EC:1.1.1.94	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerol-3-phosphate dehydrogenase [NAD(P)(+)]"
EC:1.1.1.94	skos:altLabel	"glycerol 3-phosphate dehydrogenase (NADP)"
EC:1.1.1.94	skos:altLabel	"L-glycerol-3-phosphate:NAD(P) oxidoreductase"
EC:1.1.1.94	skos:altLabel	"glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate))"
REACT:R-HSA-210294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-2 (Homo sapiens)
RHEA:53443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate
GO:0052720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	class II DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0052720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	class II DNA-(apurinic or apyrimidinic site) lyase activity
REACT:R-CFA-418172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB2 (Canis familiaris)
REACT:R-BTA-5653754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Bos taurus)
RHEA:24692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferyl acetate + NADPH => acetate + eugenol + NADP(+)
RHEA:54325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]
RHEA:70358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-carboxybiuret + H(+) <=> biuret + CO2
REACT:R-DRE-6786155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLN binds ICL-DNA (Danio rerio)
REACT:R-HSA-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Homo sapiens)
REACT:R-XTR-5654658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS bind to PPTN11 (Xenopus tropicalis)
REACT:R-SSC-5638157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Sus scrofa)
RHEA:28650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetophenone + 2 ATP + H2O + hydrogencarbonate <=> 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate
RHEA:31269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxohexanoate + H(+) + NADPH => 6-hydroxyhexanoate + NADP(+)
RHEA:40134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H2O <=> (9Z)-hexadecenoate + CoA + H(+)
REACT:R-BTA-1606583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) (Bos taurus)
REACT:R-HSA-113429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongating transcript encounters a lesion in the template (Homo sapiens)
RHEA:34473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acryloyl-CoA + H(+) + NADH => NAD(+) + propanoyl-CoA
GO:0050737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-hydroxycinnamoyltransferase activity
REACT:R-HSA-1799335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)
REACT:R-DRE-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Danio rerio)
REACT:R-RNO-9023619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Rattus norvegicus)
RHEA:58063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfinoacetaldehyde + H2O <=> acetaldehyde + H(+) + sulfite
RHEA:25621	skos:altLabel	"tuberculosinol diphosphate synthase"
RHEA:25621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate = tuberculosinyl diphosphate
RHEA:25621	skos:prefLabel	"halimadienyl-diphosphate synthase"
RHEA:25621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"halimadienyl-diphosphate synthase"
REACT:R-MMU-375395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5a receptor binds C5a anaphylatoxin (Mus musculus)
REACT:R-MMU-109671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Mus musculus)
RHEA:51721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)
REACT:R-MMU-190261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3c binds to FGF (Mus musculus)
RHEA:43971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate
GO:0034282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-pimara-8(14),15-diene synthase activity
GO:0034282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming] activity
GO:0034282	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ent-pimaradiene synthase activity
RHEA:31833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:42584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-BTA-398040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma activation of PLC beta (Bos taurus)
REACT:R-GGA-9648017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 binds to microtubules (Gallus gallus)
REACT:R-DME-70881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Drosophila melanogaster)
REACT:R-BTA-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Bos taurus)
REACT:R-MMU-6782820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates SUDS3 (Mus musculus)
RHEA:72067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + ATP + L-glutamate = ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate
REACT:R-XTR-9750656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Xenopus tropicalis)
RHEA:57338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose
RHEA:65732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + heptyl sulfate + O2 = CO2 + H(+) + heptanal + succinate + sulfate
REACT:R-SSC-193780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Sus scrofa)
RHEA:14601	skos:altLabel	"lysine oxygenase"
RHEA:14601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine + O2 = 5-aminopentanamide + CO2 + H2O
RHEA:14601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lysine 2-monooxygenase"
RHEA:14601	skos:prefLabel	"lysine 2-monooxygenase"
REACT:R-SSC-75083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Sus scrofa)
REACT:R-DME-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Drosophila melanogaster)
REACT:R-HSA-5691439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRISC complex deubiquitinates NLRP3 (Homo sapiens)
GO:0033880	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylglyoxylyl-CoA hydrolase activity
GO:0033880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylacetyl-CoA hydrolase activity
REACT:R-DME-5658435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs bind RAS:GTP (Drosophila melanogaster)
RHEA:33682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine
REACT:R-SSC-8851298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR143 binds L-Dopa (Sus scrofa)
REACT:R-XTR-74737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)
REACT:R-SSC-8948039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by CK2 (Sus scrofa)
REACT:R-CEL-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Caenorhabditis elegans)
RHEA:47024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)
REACT:R-XTR-6787540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUK phosphorylates beta-Fuc to Fuc1P (Xenopus tropicalis)
REACT:R-SPO-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Schizosaccharomyces pombe)
REACT:R-DME-2024108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Some HSPGs are secreted to the plasma membrane (Drosophila melanogaster)
REACT:R-DRE-1482547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is acylated to PC by LPCAT (Danio rerio)
RHEA:18888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
REACT:R-XTR-352103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Xenopus tropicalis)
GO:0043999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H2A-K5 specific)
GO:0043999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H2A-K5 specific)
GO:0043999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H2A-K5 specific)
GO:0043999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AK5 acetyltransferase activity
GO:0043999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2A-K5 acetyltransferase activity
REACT:R-SSC-389611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Sus scrofa)
REACT:R-BTA-389532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A binds CTLA4 dimer (Bos taurus)
REACT:R-MMU-419981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Mus musculus)
REACT:R-HSA-8985293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NKX3-2 binds RUNX2 gene promoter (Homo sapiens)
REACT:R-CFA-193709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
RHEA:13541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetrathionate = H(+) + sulfate + sulfur + thiosulfate
RHEA:58204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-HSA-5654592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
REACT:R-BTA-158311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Bos taurus)
RHEA:11703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + progesterone <=> H2O + NADP(+) + testosterone acetate
REACT:R-DME-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Drosophila melanogaster)
RHEA:34064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxystreptamine + UDP-alpha-D-glucose => 2'-deamino-2'-hydroxyparomamine + H(+) + UDP
RHEA:59559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiono-1,5-lactone <=> H(+) + N,N'-diacetylchitobionate
GO:0070540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stearic acid binding
RHEA:33639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA
RHEA:23109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinono-1,4-lactone + H2O => D-arabinonate + H(+)
RHEA:69438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxypregnenolone + NADP(+) => 7-oxopregnenolone + H(+) + NADPH
RHEA:11411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + riboflavin <=> lumichrome + ribitol
REACT:R-XTR-8850854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)
REACT:R-HSA-9629372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to thymine glycol in telomeric DNA (Homo sapiens)
REACT:R-RNO-8849055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds ARHGAP35 (Rattus norvegicus)
RHEA:16505	skos:prefLabel	"chorismate lyase"
RHEA:16505	skos:altLabel	"CL"
RHEA:16505	skos:altLabel	"CPL"
RHEA:16505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate = 4-hydroxybenzoate + pyruvate
RHEA:16505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chorismate lyase"
RHEA:67971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + presqualene diphosphate <=> H(+) + phosphate + presqualene monophosphate
GO:0048040	skos:altLabel	"UDP-D-glucuronate carboxy-lyase"
GO:0048040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-glucuronate carboxy-lyase activity
GO:0048040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucuronate decarboxylase activity
GO:0048040	skos:prefLabel	"UDP-glucuronate decarboxylase"
GO:0048040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine-diphosphoglucuronate decarboxylase activity
GO:0048040	skos:altLabel	"UDP-glucuronic acid decarboxylase"
GO:0048040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)
GO:0048040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose
GO:0048040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-glucuronate decarboxylase"
GO:0048040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucuronic acid decarboxylase activity
GO:0048040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucuronate decarboxylase activity
REACT:R-BTA-2213240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of disulphide bonds in MHC II antigens (Bos taurus)
RHEA:55457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol
REACT:R-DRE-9700120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTN and MDK bind to PTPRZ (Danio rerio)
REACT:R-HSA-6782685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5 (Homo sapiens)
RHEA:53483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH <=> 5alpha-androstane-3beta,17beta-diol + NADP(+)
REACT:R-DME-555065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of clathrin coated vesicle (Drosophila melanogaster)
REACT:R-XTR-8987266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Xenopus tropicalis)
REACT:R-BTA-209859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decarboxylation of 5-hydroxytryptophan forms serotonin (Bos taurus)
REACT:R-CEL-77283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Caenorhabditis elegans)
RHEA:56294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-9647977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT methylates S-Farn RAS proteins (Bos taurus)
REACT:R-DRE-9693478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A agonists (Danio rerio)
RHEA:67553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + cholate => adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)
REACT:R-CFA-8849891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-3 bind to PSD-95 family members (Canis familiaris)
REACT:R-RNO-176585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Rattus norvegicus)
REACT:R-XTR-2855077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-3 binds to molecular patterns on the target cell surface  (Xenopus tropicalis)
GO:0050191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglycerate kinase (GTP) activity
GO:0050191	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP:3-phospho-D-glycerate 1-phosphotransferase activity
RHEA:66526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate(out) + monodehydro-L-ascorbate radical(in) => L-ascorbate(in) + monodehydro-L-ascorbate radical(out)
REACT:R-HSA-9760099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcK-NFE2L2 binds the GCLC gene (Homo sapiens)
REACT:R-GGA-2186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of Ub-SMAD7 (Gallus gallus)
RHEA:26494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + L-tryptophan + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O
RHEA:26494	skos:prefLabel	"tryptophan 7-halogenase"
RHEA:26494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan 7-halogenase"
RHEA:54785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
RHEA:46454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu) => 2 L-leucyl-tRNA(Leu)
GO:0052817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	very long-chain acyl-thioester hydrolase activity
GO:0052817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	very long-chain-acyl-CoA hydrolase activity
GO:0052817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	very long-chain hydrolase activity
GO:0052817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	very long-chain acyl coenzyme A hydrolase activity
GO:0052817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	very long chain acyl-CoA hydrolase activity
RHEA:55845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + UDP-alpha-D-glucuronate => calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP
REACT:R-CEL-8877192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds FOXP3 (Caenorhabditis elegans)
REACT:R-BTA-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Bos taurus)
REACT:R-XTR-200318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Xenopus tropicalis)
REACT:R-DME-8848582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Drosophila melanogaster)
RHEA:55528	skos:prefLabel	"4-hydroxyphenylacetaldehyde synthase"
RHEA:55528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + L-tyrosine + O2 = (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)
RHEA:55528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxyphenylacetaldehyde synthase"
REACT:R-HSA-210291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Homo sapiens)
REACT:R-HSA-199202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphopantetheine conjugation of the ACP domain of FAS (Homo sapiens)
RHEA:21216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribokinase"
RHEA:21216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)
RHEA:21216	skos:prefLabel	"phosphoribokinase"
REACT:R-DRE-8950485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Danio rerio)
REACT:R-CFA-870477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Canis familiaris)
RHEA:68902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 4-methoxybenzoate + ATP + H(+) + NADPH
REACT:R-CEL-3247840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS binds WNT ligands in the Golgi (Caenorhabditis elegans)
RHEA:46790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:50877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH => a hydroxy polyunsaturated fatty acid + H2O + NADP(+)
GO:0050146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside phosphotransferase activity
GO:0050146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleotide:2'-nucleoside 5'-phosphotransferase activity
GO:0050146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nonspecific nucleoside phosphotransferase activity
GO:0050146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleotide:nucleoside 5'-phosphotransferase activity
GO:0050146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity
RHEA:70579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-BTA-8875320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 GEFs exchange GTP for GDP on RAB5 (Bos taurus)
RHEA:20195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + mevaldate + NADPH => (R)-mevalonate + NADP(+)
REACT:R-HSA-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Homo sapiens)
RHEA:49536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O
RHEA:67478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + prekainate => dimethylallyl diphosphate + L-glutamate
GO:0032003	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-28
GO:0032003	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-28 receptor ligand
GO:0032003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-28 receptor binding
REACT:R-DRE-389986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Danio rerio)
RHEA:43473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate
RHEA:23578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:50460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"medium-chain-fatty-acid--[acyl-carrier-protein] ligase"
RHEA:50460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + ATP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + diphosphate
RHEA:50460	skos:prefLabel	"medium-chain-fatty-acid--[acyl-carrier-protein] ligase"
GO:0062124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-hydroxybutyrate receptor activity
GO:0062124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutyrate receptor activity
GO:1990247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6-methyladenosine-containing RNA binding
RHEA:65662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + calcidiol => A + calciol + H2O
GO:0140824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thioredoxin-dependent peroxiredoxin activity
RHEA:10701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + limonene 1,2-epoxide => limonene-1,2-diol
RHEA:57000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + streptothricin F = CoA + H(+) + N(beta)-acetylstreptothricin F
REACT:R-CFA-139842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Syk tyrosine kinase (Canis familiaris)
REACT:R-HSA-9668597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)
RHEA:16695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methyl-5-isopropylhexa-2,5-dienal => alpha-pinene oxide
EC:3.4.23.5	skos:prefLabel	"cathepsin D"
EC:3.4.23.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cathepsin D"
RHEA:31961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DRE-5654157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR2 (Danio rerio)
REACT:R-DDI-1678660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan sulfate chain(3) (Dictyostelium discoideum)
REACT:R-MMU-109341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Mus musculus)
REACT:R-BTA-432121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL binds to LRP8 (Bos taurus)
GO:0018839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity
RHEA:36976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + phosphate => adenine + alpha-D-ribose 1,5-bisphosphate
REACT:R-XTR-391935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DP1 receptor can bind PGD2 (Xenopus tropicalis)
REACT:R-SPO-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Schizosaccharomyces pombe)
RHEA:25055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)
REACT:R-DME-6807118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)
REACT:R-CEL-187545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cks1 with SCF(Skp2) complex (Caenorhabditis elegans)
RHEA:55304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
REACT:R-BTA-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Bos taurus)
RHEA:41908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O
GO:0047903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose:NADP+ 5-oxidoreductase activity
GO:0047903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 5-dehydrogenase (NADP+) activity
GO:0047903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-keto-D-fructose reductase (NADP+)
GO:0047903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-ketofructose reductase (NADP(+)) activity
GO:0047903	skos:altLabel	"5-ketofructose reductase (NADP(+))"
GO:0047903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-ketofructose reductase (NADP+) activity
GO:0047903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-(-)fructose:(NADP+) 5-oxidoreductase activity
GO:0047903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructose 5-dehydrogenase (NADP(+))"
GO:0047903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH
GO:0047903	skos:altLabel	"5-ketofructose reductase (NADP+)"
GO:0047903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-ketofructose reductase (NADP)
GO:0047903	skos:prefLabel	"fructose 5-dehydrogenase (NADP(+))"
GO:0047903	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
REACT:R-DRE-166220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion diffuses laterally to UCP (Danio rerio)
RHEA:56572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = globoside Gb3Cer + H(+) + UDP
REACT:R-XTR-1630306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses a glycosaminoglycan (Xenopus tropicalis)
RHEA:11310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + malonyl-CoA + phosphate => acetyl-CoA + ATP + hydrogencarbonate
RHEA:32189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one => cholest-5-en-3-one
RHEA:65831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + neryl diphosphate <=> diphosphate + nerol
REACT:R-SSC-3827958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by MMP9, KLK7 (Sus scrofa)
RHEA:56240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]
RHEA:47420	skos:prefLabel	"glutaryl-CoA dehydrogenase (acceptor)"
RHEA:47420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutaryl-CoA dehydrogenase (acceptor)"
RHEA:47420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + glutaryl-CoA = (2E)-glutaconyl-CoA + AH2
GO:0030955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium ion binding
GO:0030955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K ion binding
REACT:R-SSC-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Sus scrofa)
GO:0050337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfane sulfurtransferase activity
GO:0050337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate-thiol sulfurtransferase activity
GO:0050337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfane reductase activity
GO:0050337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate:thiol sulfurtransferase activity
GO:0050337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulphate-thiol sulphurtransferase activity
GO:0050337	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione-dependent thiosulfate reductase activity
RHEA:67912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid
RHEA:51781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlormethylbutanophenone + dimethylallyl diphosphate => deoxyadlupulone + diphosphate
RHEA:17729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + cholesterol = a cholesterol ester + CoA
REACT:R-HSA-9619668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-PRX:DRP:DGC:laminin-211 interacts with UTRN (Homo sapiens)
REACT:R-XTR-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Xenopus tropicalis)
RHEA:28567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP => 6 AMP + enterobactin + 7 H(+)
REACT:R-CEL-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Caenorhabditis elegans)
REACT:R-CFA-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Canis familiaris)
REACT:R-BTA-2161794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is converted to HXA3/B3 by ALOX12 (Bos taurus)
RHEA:44651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)
RHEA:69412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol
RHEA:35842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> a cardiolipin + CoA
RHEA:19053	skos:prefLabel	"methenyltetrahydromethanopterin cyclohydrolase"
RHEA:19053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methenyltetrahydromethanopterin cyclohydrolase"
RHEA:19053	skos:altLabel	"methenyl-H(4)MPT cyclohydrolase"
RHEA:19053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin
REACT:R-XTR-201640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Xenopus tropicalis)
RHEA:57867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0140770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]
GO:0140770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-dependent peptidyl-lysine N6-myristoyltransferase activity
RHEA:64709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + NADP(+) => butanal + H(+) + NADPH
REACT:R-SSC-9762094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3B phosphorylates p-NFE2L2 (Sus scrofa)
REACT:R-BTA-70920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Bos taurus)
REACT:R-HSA-5683840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPB gene produces pro-SFTPB protein (Homo sapiens)
REACT:R-SPO-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Schizosaccharomyces pombe)
REACT:R-SSC-9700175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates SHC1 (Sus scrofa)
REACT:R-SSC-1604712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP7 by trypsin (Sus scrofa)
RHEA:48162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:63853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 => (2R)-2-hydroperoxydodecanoate
REACT:R-SSC-110250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenoadenine by MPG glycosylase (Sus scrofa)
REACT:R-XTR-3788748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL6 promoter (Xenopus tropicalis)
REACT:R-SPO-6811412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer to the Golgi (Schizosaccharomyces pombe)
RHEA:14302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxolactone + H2O => 4-pyridoxate + H(+)
REACT:R-RNO-114684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Syntaxin-4 (Rattus norvegicus)
REACT:R-HSA-9622831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Substrate:LAMP2a binds HSP90 (Homo sapiens)
REACT:R-CFA-8852128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the nucleoplasm (Canis familiaris)
REACT:R-HSA-167192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the HIV-1 template as transcript elongates (Homo sapiens)
REACT:R-XTR-9731590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)
REACT:R-BTA-8856951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A demethylation by PPME1 (Bos taurus)
REACT:R-RNO-193743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
REACT:R-RNO-8869456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP4 deubiquitinate TRAF2,TRAF6 (Rattus norvegicus)
REACT:R-BTA-8981637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)
REACT:R-DME-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Drosophila melanogaster)
RHEA:38740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol
GO:0004968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GnRH receptor activity
GO:0004968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gonadotropin-releasing hormone receptor activity
GO:0004968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gonadotrophin-releasing hormone receptor activity
RHEA:55772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"jasmonoyl--L-amino acid ligase"
RHEA:55772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a jasmonate + an L-alpha-amino acid + ATP = a jasmonyl-L-amino acid + AMP + diphosphate + H(+)
RHEA:55772	skos:prefLabel	"jasmonoyl--L-amino acid ligase"
RHEA:37190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
REACT:R-MMU-74737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)
RHEA:16293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopropylmaleate + H2O = (2S)-2-isopropylmalate
RHEA:13392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]
REACT:R-MMU-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Mus musculus)
REACT:R-BTA-8938108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds cathepsin L (Bos taurus)
RHEA:26552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-piperazine-2-carboxylate + NH4(+) => (S)-piperazine-2-carboxamide + H2O
RHEA:43425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
GO:0050623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	berberine reductase activity
GO:0050623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-tetrahydroberberine:NADP+ oxidoreductase activity
GO:0050623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-canadine synthase activity
RHEA:21520	skos:prefLabel	"formate dehydrogenase (cytochrome)"
RHEA:21520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome b1] + formate = CO2 + 2 Fe(II)-[cytochrome b1] + H(+)
RHEA:21520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate dehydrogenase (cytochrome)"
REACT:R-DRE-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Danio rerio)
REACT:R-DME-5660666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBP and p300 binds NF-kB complex (Drosophila melanogaster)
REACT:R-HSA-982778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone binds the growth hormone receptor (Homo sapiens)
REACT:R-DDI-8954468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Dictyostelium discoideum)
REACT:R-BTA-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Bos taurus)
REACT:R-DME-5654586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)
RHEA:57504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate
REACT:R-SPO-72697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Start codon recognition (Schizosaccharomyces pombe)
RHEA:29623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-maltopentaose + beta-maltose = alpha-maltohexaose + beta-D-glucose
REACT:R-GGA-2997709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO1 (Gallus gallus)
REACT:R-DME-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Drosophila melanogaster)
REACT:R-GGA-3928657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2,9 cleave EPHB (Gallus gallus)
GO:0008695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phenylpropanoate dioxygenase activity
GO:0008695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpropionate dioxygenase activity
GO:0008695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Hca dioxygenase activity
GO:0008695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HcaA1A2CD
GO:0008695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity
REACT:R-DME-3322424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CDC73 and LEO1 (Drosophila melanogaster)
RHEA:31172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxytetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O
RHEA:48995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,7-trimethylurate + H(+) + NADH + O2 <=> 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-oxo-3-deoxygalactonate 6-phosphate aldolase activity
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-2-keto-3-deoxygalactonate aldolase activity
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(KDPGal)aldolase activity
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-6-phosphogalactonic aldolase activity
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-2-dehydro-3-deoxygalactonate aldolase activity
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-keto-3-deoxygalactonate aldolase activity
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-2-keto-3-deoxygalactonic aldolase activity
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity
GO:0008674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxyphosphogalactonate aldolase activity
REACT:R-DME-74843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 to form RBP1:atROL (Drosophila melanogaster)
REACT:R-CFA-9005980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 binds IL21R:JAK1 (Canis familiaris)
REACT:R-XTR-1254248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of ERBB4s80:YAP1 complex to the nucleus (Xenopus tropicalis)
REACT:R-SPO-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Schizosaccharomyces pombe)
RHEA:60525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:47356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an octanoate ester + H2O = an aliphatic alcohol + H(+) + octanoate
REACT:R-SSC-374664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of Ezrin (Sus scrofa)
RHEA:24036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nucleoside-phosphate kinase"
RHEA:24036	skos:altLabel	"NMP-kinase"
RHEA:24036	skos:prefLabel	"nucleoside-phosphate kinase"
RHEA:24036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP
REACT:R-GGA-9750555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Gallus gallus)
RHEA:63999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)
REACT:R-CFA-9013022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)
REACT:R-SSC-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Sus scrofa)
RHEA:15068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-benzoylagmatine <=> agmatine + benzoate
RHEA:70341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose => alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O
RHEA:44309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
RHEA:49251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> galactitol 1-phosphate(in) + L-histidyl-[protein]
RHEA:41098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphing-4-enine-phosphocholine <=> H(+) + phosphocholine + sphing-4-enine
RHEA:48150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)/18:0) + H2O
REACT:R-RNO-388814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds CD28 (Rattus norvegicus)
REACT:R-CEL-113413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIS-mediated recovery of elongation from arrest (Caenorhabditis elegans)
RHEA:48144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine = ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate
REACT:R-DRE-8850997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 binds PTEN (Danio rerio)
REACT:R-BTA-2161195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Bos taurus)
REACT:R-BTA-2855252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKRs reduce RBP2:atRAL to RBP2:atROL (Bos taurus)
REACT:R-XTR-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Xenopus tropicalis)
REACT:R-DME-5665998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 binds SRF (Drosophila melanogaster)
REACT:R-HSA-9729741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 3CLpro dimer cleaves NLRP12 (Homo sapiens)
RHEA:28103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + H2O => D-mannose + GDP + H(+)
REACT:R-SSC-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Sus scrofa)
RHEA:10331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-glycol + NAD(+) <=> a 2-hydroxycarbonyl + H(+) + NADH
REACT:R-SSC-8848246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Sus scrofa)
REACT:R-DRE-9649735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Intrinsic nucleotide exchange on RAS (Danio rerio)
RHEA:35993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-GGA-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)
REACT:R-HSA-449718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a third mannose to the N-glycan precursor by ALG2 (Homo sapiens)
RHEA:43696	skos:altLabel	"PPDK regulatory protein"
RHEA:43696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"([Pyruvate, phosphate dikinase] phosphate) phosphotransferase"
RHEA:43696	skos:altLabel	"bifunctional dikinase regulatory protein"
RHEA:43696	skos:altLabel	"pyruvate, phosphate dikinase regulatory protein"
RHEA:43696	skos:prefLabel	"([Pyruvate, phosphate dikinase] phosphate) phosphotransferase"
RHEA:43696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]
REACT:R-CEL-2031355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Caenorhabditis elegans)
REACT:R-RNO-446364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Migfilin interacts with VASP (Rattus norvegicus)
REACT:R-RNO-5226979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD2 binds DMTN (Rattus norvegicus)
REACT:R-RNO-433114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NaS1 co-transports sulphate and a sodium ion (Rattus norvegicus)
RHEA:71190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine(out) + L-tryptophan(in) <=> 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)
RHEA:53842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+)
RHEA:55320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]
REACT:R-DRE-8987141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Danio rerio)
RHEA:40179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2
RHEA:33148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + daunorubicin(in) + H2O => ADP + daunorubicin(out) + H(+) + phosphate
RHEA:64268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	emodin anthrone + O2 = emodin + H(+) + H2O
REACT:R-CEL-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)
REACT:R-HSA-9759454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports PREDN,PREDL out of kidney cells (Homo sapiens)
REACT:R-CEL-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)
GO:0005528	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FK506-sensitive peptidyl-prolyl cis-trans isomerase
GO:0005528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FK506 binding
REACT:R-DRE-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Danio rerio)
RHEA:25418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + A + 2 H2O => AH2 + O2 + octadecanoyl-CoA
GO:0016875	skos:prefLabel	"Forming carbon-oxygen bonds"
GO:0016875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming carbon-oxygen bonds"
GO:0016875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ligase activity, forming carbon-oxygen bonds
REACT:R-HSA-2230983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP1:Hemopexin:heme is endocytosed (Homo sapiens)
RHEA:11473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-methyl-L-amino acid + H2O + O2 => an L-alpha-amino acid + formaldehyde + H2O2
RHEA:13755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + L-glutamine + NADH => 2 L-glutamate + NAD(+)
REACT:R-RNO-8953115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds to MGA:MAX (Rattus norvegicus)
REACT:R-SPO-9645598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D hydrolyzes GTP (Schizosaccharomyces pombe)
RHEA:55272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA
RHEA:45825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine => CO2 + ethanolamine
RHEA:52593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholoyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH
REACT:R-BTA-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Bos taurus)
REACT:R-XTR-75862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Xenopus tropicalis)
REACT:R-HSA-443783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NUMB with L1 (Homo sapiens)
RHEA:45795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 <=> [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate
REACT:R-HSA-1306979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)
REACT:R-DRE-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Danio rerio)
REACT:R-MMU-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Mus musculus)
REACT:R-RNO-9630923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B inhibitor binds NF-kappa-B complex (Rattus norvegicus)
GO:0034953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	perillyl-CoA hydratase activity
REACT:R-MMU-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Mus musculus)
RHEA:14056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose 5-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate
REACT:R-DRE-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Danio rerio)
REACT:R-SSC-8848087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAP2 recruits STAT3 to PTK6 (Sus scrofa)
REACT:R-XTR-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Xenopus tropicalis)
RHEA:62746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylbutanoate + compactin diol lactone + H(+) => H2O + mevastatin
REACT:R-MMU-2046088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Mus musculus)
GO:0050515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-ME kinase activity
GO:0050515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity
GO:0050515	skos:altLabel	"4-diphosphocytidyl-2-C-methyl-D-erythritol kinase"
GO:0050515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMK activity
GO:0050515	skos:altLabel	"CMK"
GO:0050515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase"
GO:0050515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity
GO:0050515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
GO:0050515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)
GO:0050515	skos:altLabel	"CDP-ME kinase"
GO:0050515	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity
GO:0050515	skos:prefLabel	"4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase"
REACT:R-DRE-209924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopa is decarboxylated to dopamine (Danio rerio)
REACT:R-DRE-200318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Danio rerio)
REACT:R-DME-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Drosophila melanogaster)
RHEA:29224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinone-8 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + menaquinol-8
REACT:R-RNO-2404142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds RBP1 (Rattus norvegicus)
REACT:R-GGA-9014293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GDIs block activation of RAC2 (Gallus gallus)
GO:0008909	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isochorismate synthetase activity
GO:0008909	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isochorismate hydroxymutase activity
GO:0008909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochorismate synthase activity
GO:0008909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochorismate mutase activity
EC:3.4.23.51	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"HycI peptidase"
EC:3.4.23.51	skos:prefLabel	"HycI peptidase"
REACT:R-HSA-167284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)
REACT:R-SSC-3249390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Sus scrofa)
REACT:R-CEL-5661124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD6 demethylates MeR4-HIST1H4 (Caenorhabditis elegans)
REACT:R-GGA-2176503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of SMAD2/3:SMAD4 complex (Gallus gallus)
RHEA:60007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O <=> (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate
REACT:R-SSC-265682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Sus scrofa)
RHEA:10377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Cu(2+)(in) + H2O => ADP + Cu(2+)(out) + H(+) + phosphate
REACT:R-RNO-1676162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Rattus norvegicus)
RHEA:20366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoethanolamine + S-adenosyl-L-methionine => H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
REACT:R-HSA-1358801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB3 binds RNF41 ubiquitin ligase (Homo sapiens)
RHEA:61409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-erythrulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine
RHEA:39575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)
REACT:R-MMU-75097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the export-competent mRNP complex through the NPC (Mus musculus)
RHEA:70050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + L-kynurenine <=> H2O + kynurenate + L-2-aminoadipate
RHEA:70516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose => 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP
REACT:R-CEL-8873850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD5 binds DCA, LCA (Caenorhabditis elegans)
RHEA:32037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+) => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O
REACT:R-RNO-8944250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXV (Rattus norvegicus)
RHEA:34716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine + ATP => 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)
REACT:R-PFA-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Plasmodium falciparum)
REACT:R-HSA-9013023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GEFs activate RHOB (Homo sapiens)
REACT:R-SCE-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Saccharomyces cerevisiae)
RHEA:19992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thio-alpha-D-ribose 1-phosphate <=> S-methyl-5-thio-D-ribulose 1-phosphate
REACT:R-GGA-5693620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop formation mediated by PALB2, BRCA2 and RAD51 (Gallus gallus)
REACT:R-CFA-73596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => dUMP + NH4+ (Canis familiaris)
REACT:R-RNO-2090038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses heparan chain(2) (Rattus norvegicus)
REACT:R-HSA-6785648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEMO1 binds RHOA:GTP:DIAPH1 (Homo sapiens)
RHEA:43499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH
GO:0008442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyisobutyrate dehydrogenase activity
RHEA:43709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + hexadecanoate => diphosphate + hexadecanoyl-AMP
REACT:R-CFA-187035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pro-beta-NGF and mature beta-NGF are secreted (Canis familiaris)
RHEA:19648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-threo-aldose + NAD(+) <=> a D-threo-aldono-1,5-lactone + H(+) + NADH
RHEA:29563	skos:altLabel	"murein peptide ligase"
RHEA:29563	skos:prefLabel	"UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase"
RHEA:29563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase"
RHEA:29563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
REACT:R-MMU-8950181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Y693-STAT4 dimer translocates to the nucleus (Mus musculus)
RHEA:11872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]
RHEA:11872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"corticosterone 18-monooxygenase"
RHEA:11872	skos:altLabel	"corticosterone 18-hydroxylase"
RHEA:11872	skos:altLabel	"corticosterone methyl oxidase"
RHEA:11872	skos:prefLabel	"corticosterone 18-monooxygenase"
REACT:R-CEL-6789126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)
RHEA:68756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine
RHEA:54533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4-oxoglutaryl)-L-cysteinylglycine => 2-oxoglutarate + L-cysteinylglycine
RHEA:49044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + protoasukamycin = 4-hydroxyprotoasukamycin + H2O + NAD(+)
RHEA:49044	skos:prefLabel	"protoasukamycin 4-monooxygenase"
RHEA:49044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protoasukamycin 4-monooxygenase"
REACT:R-RNO-197186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)
RHEA:18357	skos:prefLabel	"tropinone reductase I"
RHEA:18357	skos:altLabel	"TR-I"
RHEA:18357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tropinone reductase I"
RHEA:18357	skos:altLabel	"tropine dehydrogenase"
RHEA:18357	skos:altLabel	"tropinone reductase"
RHEA:18357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + tropine = H(+) + NADPH + tropinone
RHEA:14318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	morphine + NAD(+) => H(+) + morphinone + NADH
REACT:R-RNO-8954117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1 binds EPC1 (Rattus norvegicus)
RHEA:53676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
REACT:R-CFA-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Canis familiaris)
REACT:R-HSA-4551453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling (Homo sapiens)
RHEA:36182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + CDP-choline <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-HSA-1855188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 transports from the cytosol to the nucleus (Homo sapiens)
RHEA:46049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactosamine 6-phosphate => alpha-D-galactosamine 1-phosphate
REACT:R-SSC-5666008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCAI binds SRF:MKL1 (Sus scrofa)
REACT:R-DME-622325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)
REACT:R-MMU-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Mus musculus)
REACT:R-GGA-983145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Gallus gallus)
GO:0033285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent monocarboxylic acid transmembrane transporter activity
GO:0033285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled monocarboxylic acid transmembrane transporter activity
GO:0033285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monocarboxylic acid-transporting ATPase activity
REACT:R-MMU-9679740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITGA4:ITGB1 binds natalizumab (Mus musculus)
RHEA:59953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dimethylheptanoyl-CoA + H2O => 2,6-dimethylheptanoate + CoA + H(+)
REACT:R-HSA-5651942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP (Homo sapiens)
RHEA:67575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-muricholate <=> adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)
RHEA:47735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:10554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-D-glucose + H2O2 => D-glucose + O2
RHEA:25409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-alpha-D-glucose + D-glucose => ADP + alpha,alpha-trehalose + H(+)
RHEA:56134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine dimer in DNA => (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA
RHEA:13135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + CDP + H(+) => CTP + di-trans,poly-cis-dolichol
REACT:R-DRE-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Danio rerio)
GO:0019899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enzyme binding
RHEA:72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate
REACT:R-CEL-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Caenorhabditis elegans)
REACT:R-SPO-9018745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ GAPs stimulate RHOQ GTPase activity (Schizosaccharomyces pombe)
GO:0004398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histidine decarboxylase"
GO:0004398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-histidine = CO2 + histamine
GO:0004398	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidine decarboxylase activity
GO:0004398	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidine carboxy-lyase activity
GO:0004398	skos:prefLabel	"histidine decarboxylase"
GO:0004398	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidine carboxy-lyase (histamine-forming)
GO:0004398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine decarboxylase activity
GO:0004398	skos:altLabel	"L-histidine carboxy-lyase"
REACT:R-GGA-183067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Localization of CBL:GRB2 to the membrane (Gallus gallus)
REACT:R-HSA-428007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled histidine and di-peptide cotransport (Homo sapiens)
REACT:R-XTR-170677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Xenopus tropicalis)
RHEA:16215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-XTR-5687091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4 binds MAPKAPK5 (Xenopus tropicalis)
GO:0031809	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	H3 histamine receptor ligand
GO:0031809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3 histamine receptor binding
REACT:R-HSA-168875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HA (Homo sapiens)
REACT:R-PFA-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Plasmodium falciparum)
RHEA:58147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + ATP + cytidine(34) in elongator tRNA(Met) <=> AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)
RHEA:48959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O
REACT:R-CFA-9656893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1MW binds 11cRAL (Canis familiaris)
REACT:R-HSA-3318486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Homo sapiens)
RHEA:21778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA
REACT:R-SPO-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Schizosaccharomyces pombe)
REACT:R-DME-390931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT4, 6 and 7 receptors can bind serotonin (Drosophila melanogaster)
REACT:R-CEL-8873929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates STARD10 (Caenorhabditis elegans)
REACT:R-CFA-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Canis familiaris)
REACT:R-HSA-1169307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of N-myristoyl GAG (P12493) protein (Homo sapiens)
REACT:R-CEL-8857925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Caenorhabditis elegans)
RHEA:40924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)
REACT:R-DME-3299691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)
REACT:R-DDI-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Dictyostelium discoideum)
REACT:R-MMU-9617927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO4 binds ATXN3 (Mus musculus)
RHEA:24581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol 6-phosphate + H2O => D-sorbitol + phosphate
RHEA:69323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucoerucin + H2O <=> (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose
RHEA:40249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-carboxy-13-deoxycarminomycin + H(+) + methanol => H2O + rhodomycin D
GO:0047770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde:acceptor oxidoreductase activity
GO:0047770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxylate reductase activity
GO:0047770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxylic acid reductase activity
GO:0047770	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aldehyde:(acceptor) oxidoreductase activity
RHEA:50653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O
REACT:R-DRE-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Danio rerio)
RHEA:29193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iminosuccinate + menaquinol-8 => L-aspartate + menaquinone-8
REACT:R-BTA-8944215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XX (Bos taurus)
REACT:R-SCE-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Saccharomyces cerevisiae)
REACT:R-DME-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)
REACT:R-DME-2106625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Duplex siRNA is loaded into Argonaute (Drosophila melanogaster)
REACT:R-XTR-8983003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Xenopus tropicalis)
RHEA:24394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate => dTDP-L-dihydrostreptose + streptidine 6-phosphate
REACT:R-MMU-9703895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds CASR agonists (Mus musculus)
REACT:R-RNO-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Rattus norvegicus)
REACT:R-RNO-5690827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) ubiquitinates RIPK1 (Rattus norvegicus)
REACT:R-HSA-9693590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 dsRNA intermediates bind IFIH1:TKFC (Homo sapiens)
REACT:R-SSC-9679421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCD1 binds PDCD1 inhibitors (Sus scrofa)
RHEA:48963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O
RHEA:55426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-6805650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA2-NuRD complex deacetylates TP53 (Canis familiaris)
REACT:R-GGA-2029465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)
RHEA:66509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:24849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroshikimate => 3,4-dihydroxybenzoate + H2O
REACT:R-XTR-4084984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Xenopus tropicalis)
RHEA:25563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate <=> 9beta-pimara-7,15-diene + diphosphate
REACT:R-SSC-9011985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Sus scrofa)
GO:0047125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta1-piperideine-2-carboxylate reductase activity
GO:0047125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	P2C reductase activity
GO:0047125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-didehydropipecolic reductase activity
GO:0047125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-didehydropipecolate reductase activity
GO:0047125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D1-piperideine-2-carboxylate reductase activity
GO:0047125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta 1-piperideine-2-carboxylate reductase activity
GO:0047125	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-pipecolate:NADP+ 2-oxidoreductase activity
REACT:R-CFA-9734070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET recombinant therapeutic antibodies bind MET (Canis familiaris)
RHEA:29355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dUMP + H2O = 2'-deoxyuridine + phosphate
REACT:R-HSA-9026408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Homo sapiens)
RHEA:39679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA
RHEA:20594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-glucosamine => acetate + D-glucosamine
RHEA:18761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)
GO:0031827	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 2B serotonin receptor ligand
GO:0031827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 2B receptor binding
GO:0031827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 2B serotonin receptor binding
REACT:R-CFA-377643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
RHEA:32772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate => 2,6-dioxo-6-phenylhexa-3-enoate
RHEA:30046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate + L-aspartate <=> iminosuccinate + succinate
RHEA:18354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + K(+)(out) + Na(+)(in) => ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate
RHEA:30096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + a menaquinone => a menaquinol + oxaloacetate
REACT:R-HSA-9754775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 M protein binds MAP1LC3B (Homo sapiens)
REACT:R-DRE-3788061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by ADAM8 (Danio rerio)
REACT:R-BTA-5674385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPKs dimerize (Bos taurus)
REACT:R-MMU-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Mus musculus)
REACT:R-RNO-210294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PECAM-1 and SHP-2 (Rattus norvegicus)
GO:0030559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA pseudouridylation guide activity
REACT:R-HSA-2265534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GLB1 does not hydrolyse a glycosaminoglycan (Homo sapiens)
REACT:R-RNO-9733403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9 binds PCSK9 inhibitors (Rattus norvegicus)
REACT:R-GGA-997237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B proteins bind JAK2 (Gallus gallus)
GO:0050237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxine 4-oxidase activity
GO:0050237	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxol 4-oxidase activity
GO:0050237	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxine:oxygen 4-oxidoreductase activity
GO:0050237	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyridoxin 4-oxidase activity
RHEA:44677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + all-trans-retinol => a diacylglycerol + an all-trans-retinyl ester
REACT:R-SSC-9611851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2 bind ADR,NAd (Sus scrofa)
RHEA:46624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydantoin racemase"
RHEA:46624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-5-monosubstituted hydantoin = a L-5-monosubstituted hydantoin
RHEA:46624	skos:altLabel	"5'-monosubstituted-hydantoin racemase"
RHEA:46624	skos:prefLabel	"hydantoin racemase"
RHEA:60512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in miRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine
RHEA:32465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine => glycine + 2 S-adenosyl-L-methionine
RHEA:29363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O = 2'-deoxycytidine + phosphate
REACT:R-CFA-1482777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAG is hydrolyzed to DAG by PNPLA2/3 (Canis familiaris)
REACT:R-MMU-9687625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds MLKL (Mus musculus)
RHEA:33160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)
REACT:R-SPO-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Schizosaccharomyces pombe)
REACT:R-RNO-5683831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCDC59 binds TTF1 (Rattus norvegicus)
RHEA:18480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + O2 <=> 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)
RHEA:24079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-Delta(5)-steroid + NAD(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADH
RHEA:19499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine + CO2 => H(+) + L-aspartate
REACT:R-SSC-417927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y2 receptor binds ATP and UTP (Sus scrofa)
RHEA:25891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate + iminosuccinate <=> H(+) + 2 H2O + phosphate + quinolinate
RHEA:45521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]
RHEA:60870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O
RHEA:64156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-methionine + H2O = a fatty acid + L-methionine
RHEA:37536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
RHEA:20344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP
RHEA:45549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]
RHEA:37866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA <=> 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-9012651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)
REACT:R-CEL-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Caenorhabditis elegans)
REACT:R-DDI-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)
REACT:R-DRE-5682967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 binds DNA DSBs (Danio rerio)
REACT:R-CFA-352379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Canis familiaris)
REACT:R-HSA-5210912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) (Homo sapiens)
REACT:R-MMU-77303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Mus musculus)
REACT:R-GGA-8851298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR143 binds L-Dopa (Gallus gallus)
RHEA:22447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferol + NADP(+) <=> (E)-coniferaldehyde + H(+) + NADPH
REACT:R-BTA-909725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of IRF9 with p-STAT2:p-STAT1 (Bos taurus)
REACT:R-HSA-5251562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deletions in the AXIN1 gene prevent expression of AXIN1 protein (Homo sapiens)
RHEA:70187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose = cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose
GO:0043722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-Hpd activity
GO:0043722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-Hpd activity
GO:0043722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxyphenylacetate decarboxylase activity
GO:0043722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)
GO:0043722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate decarboxylase activity
GO:0043722	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxyphenylacetate carboxy-lyase activity
RHEA:30080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + crotonobetaine => AMP + crotonobetainyl-CoA + diphosphate
REACT:R-XTR-4093336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
REACT:R-CFA-174132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Free APC/C phosphorylated by Cyclin B:Cdc2 (Canis familiaris)
RHEA:59713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltotetraono-1,5-lactone + H2O => D-maltotetraonate + H(+)
GO:0030556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA modification guide activity
RHEA:36709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-ureido-D-serine => O-ureido-L-serine
REACT:R-CFA-444691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prokineticin receptors bind prokineticin (Canis familiaris)
REACT:R-HSA-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
REACT:R-DRE-432897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ILK interacts with beta-1 integrin (Danio rerio)
RHEA:51104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxykynurenamine + CO2 <=> 5-hydroxy-L-kynurenine + H(+)
REACT:R-RNO-199518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3d-complexed antigen binds to complement receptor (Rattus norvegicus)
REACT:R-MMU-202723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha5beta1 binds FN1 dimer (Mus musculus)
RHEA:23701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + H2O => (6S)-10-formyltetrahydrofolate + H(+)
REACT:R-DDI-9014295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GAPs stimulate RAC2 GTPase activity (Dictyostelium discoideum)
GO:0047772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)
GO:0047772	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carboxymethyloxysuccinate glycolate-lyase activity
GO:0047772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxymethyloxysuccinate lyase activity
REACT:R-MMU-193668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR and RHOA-GDI interact (Mus musculus)
RHEA:46016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20R)-20-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone
REACT:R-MMU-5362427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds GPC5 (Mus musculus)
REACT:R-HSA-163310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAM binds to mitochondrial promoters (Homo sapiens)
RHEA:64752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanylpentan-1-ol-L-cysteine + H2O = 3-sulfanyl-1-pentanol + NH4(+) + pyruvate
REACT:R-GGA-421495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of ALAS2 nascent polypeptide (Gallus gallus)
RHEA:45191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
RHEA:19602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + orcinol => 2,3,5-trihydroxytoluene + H2O + NAD(+)
GO:0043792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity
GO:0043792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enamidase activity
REACT:R-BTA-8981553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Bos taurus)
RHEA:64505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine => 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine
RHEA:17580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-D-glycero-beta-D-manno-heptose <=> ADP-L-glycero-beta-D-manno-heptose
REACT:R-MMU-8852351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 promotes translocation of TP53 to the cytosol (Mus musculus)
RHEA:26484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N(6)-dimethylallyladenosine(37) in tRNA => adenosine(37) in tRNA + dimethylallyl diphosphate
REACT:R-DME-448958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear translocation of p38 MAPK (Drosophila melanogaster)
RHEA:59904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + octanal = 2 H(+) + NADPH + octanoate
RHEA:26404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-10'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone
REACT:R-MMU-5654407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates SHC1 (Mus musculus)
REACT:R-CEL-507875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea into cells (Caenorhabditis elegans)
REACT:R-GGA-8942302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP13 cleaves OPTC (Gallus gallus)
REACT:R-BTA-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Bos taurus)
REACT:R-HSA-6806394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 and AP-1 stimulate MSH2 expression (Homo sapiens)
REACT:R-CFA-8849878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSD-95 binds NMDA receptor (Canis familiaris)
REACT:R-GGA-202165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ITAM motifs in CD3 complexes (Gallus gallus)
REACT:R-HSA-9006588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds the PTPN4 gene promoter (Homo sapiens)
REACT:R-GGA-1912372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fringe-modified Pre-NOTCH is cleaved by FURIN (Gallus gallus)
RHEA:72333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => 3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)
GO:0047529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dimethylmalate lyase activity
GO:0047529	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-dimethylmalate pyruvate-lyase activity
GO:0047529	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)
GO:0047529	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity
REACT:R-BTA-8938773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A polyubiquitinates PRKDC (Bos taurus)
REACT:R-DRE-9037761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)
REACT:R-CFA-446692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)
RHEA:28133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	baicalin + H2O <=> baicalein + D-glucuronate + H(+)
REACT:R-GGA-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)
REACT:R-BTA-109671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Bos taurus)
RHEA:16474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1,3-dione + H2O => 5-oxohexanoate + H(+)
GO:0008086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	light-activated voltage-dependent calcium channel activity
GO:0008086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	light-activated voltage-gated calcium channel activity
GO:0008086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	light-activated voltage gated calcium channel activity
REACT:R-RNO-4551655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Rattus norvegicus)
REACT:R-CFA-917835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from holoTF:TFRC dimer (Canis familiaris)
RHEA:19261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type heme transporter"
RHEA:19261	skos:altLabel	"heme-transporting ATPase"
RHEA:19261	skos:prefLabel	"ABC-type heme transporter"
RHEA:19261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate
REACT:R-RNO-4551465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of NFATC1:CaN:CaM to nucleus (Rattus norvegicus)
REACT:R-DDI-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Dictyostelium discoideum)
REACT:R-RNO-8870732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSGs bind proteoglycans and TGF-beta1 (Rattus norvegicus)
REACT:R-CEL-432049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-9 passively transports glycerol into cell (Caenorhabditis elegans)
REACT:R-BTA-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)
REACT:R-HSA-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Homo sapiens)
RHEA:69403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)2-lipid A + holo-[ACP]
RHEA:58021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => eupatolide + H2O
RHEA:16289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-ephedrine dehydrogenase"
RHEA:16289	skos:prefLabel	"(-)-ephedrine dehydrogenase"
RHEA:16289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH
REACT:R-DME-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)
RHEA:49285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP => CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate
REACT:R-XTR-9640195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGA,B hydrolyzes GTP (Xenopus tropicalis)
REACT:R-DRE-375340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 62 mediated neuronal gap junction communication (Danio rerio)
RHEA:55504	skos:prefLabel	"drimenol monooxygenase"
RHEA:55504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"drimenol monooxygenase"
RHEA:55504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] = (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0019149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)
GO:0019149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-chloro-D-alanine chloride-lyase (deaminating)
GO:0019149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-D-alanine dehydrochlorinase activity
GO:0019149	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-chloro-D-alanine dehydrochlorinase activity
RHEA:50825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate
REACT:R-DRE-8941915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Danio rerio)
REACT:R-MMU-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Mus musculus)
REACT:R-MMU-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Mus musculus)
RHEA:14463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP => (25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose
REACT:R-RNO-9692880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH3 binds Hist (Rattus norvegicus)
RHEA:15907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cyclohexane-1,3-dione => 3-hydroxycyclohexanone + A
REACT:R-RNO-5666001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Profilin:G-actin binds MKL1 (Rattus norvegicus)
REACT:R-SSC-453111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC recruits GRB2:SOS1 (Sus scrofa)
RHEA:37461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP
GO:0042314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bacteriochlorophyll binding
REACT:R-HSA-1474266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibrils (Homo sapiens)
RHEA:50267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:1905573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 binding
REACT:R-DME-380979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Drosophila melanogaster)
RHEA:54837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + heptan-2-one + NADPH + O2 => H2O + NADP(+) + pentyl acetate
REACT:R-SPO-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Schizosaccharomyces pombe)
REACT:R-RNO-69015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Rattus norvegicus)
RHEA:54149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O
RHEA:14149	skos:altLabel	"uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase"
RHEA:14149	skos:prefLabel	"luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase"
RHEA:14149	skos:altLabel	"LMT"
RHEA:14149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase"
RHEA:14149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP
RHEA:18565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lovastatin nonaketide synthase"
RHEA:18565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine = 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine
RHEA:18565	skos:prefLabel	"lovastatin nonaketide synthase"
GO:0019829	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	plasma membrane cation-transporting ATPase
GO:0019829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase-coupled cation transmembrane transporter activity
GO:0019829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent cation transmembrane transporter activity
GO:0019829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cation-transporting ATPase activity
GO:0019829	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cation ABC transporter
RHEA:27799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate
REACT:R-RNO-5654607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates PPTN11 (Rattus norvegicus)
REACT:R-HSA-2213205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type XII and XIV collagens associate with type I and type II fibrils. (Homo sapiens)
REACT:R-BTA-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Bos taurus)
RHEA:63335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-arabinopyanose <=> beta-L-arabinopyranose
REACT:R-XTR-111285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)
REACT:R-BTA-1614614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cysteine is degraded to serine and H2S (Bos taurus)
RHEA:27858	skos:prefLabel	"2',3'-cyclic-nucleotide 2'-phosphodiesterase"
RHEA:27858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2',3'-cyclic-nucleotide 2'-phosphodiesterase"
RHEA:27858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-GMP + H2O = 3'-GMP + H(+)
REACT:R-DRE-159567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform ST to ST-CoA (Danio rerio)
REACT:R-PFA-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Plasmodium falciparum)
GO:0008925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:maltose O-acetyltransferase activity
GO:0008925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose O-acetyltransferase activity
GO:0008925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltose transacetylase activity
RHEA:37474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine
RHEA:33976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIMBOA beta-D-glucoside + H2O => D-glucose + DIMBOA
REACT:R-DDI-8876485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from lysosome membrane to ER membrane (Dictyostelium discoideum)
REACT:R-GGA-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Gallus gallus)
REACT:R-RNO-9707586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM oxidises LDL,HDL (Rattus norvegicus)
RHEA:31806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose <=> 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP
REACT:R-BTA-9681763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1 binds IL1R1 inhibitors (Bos taurus)
RHEA:54940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-CFA-9603784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19:class I PMP binds PEX3 (Canis familiaris)
RHEA:48437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pentanoate ester => an aliphatic alcohol + H(+) + pentanoate
RHEA:20521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybutyrate dehydrogenase"
RHEA:20521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH
RHEA:20521	skos:altLabel	"D-beta-hydroxybutyrate dehydrogenase"
RHEA:20521	skos:prefLabel	"3-hydroxybutyrate dehydrogenase"
GO:0052825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
GO:0052825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Homo sapiens)
REACT:R-MMU-1433456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of STATs (Mus musculus)
RHEA:47317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-XTR-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Xenopus tropicalis)
REACT:R-DRE-9015379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor IIa inhibitors (compounds) binds IIa (Danio rerio)
REACT:R-BTA-5082387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser230 induces transactivation (Bos taurus)
REACT:R-HSA-211923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26C1 4-hydroxylates 9cRA (Homo sapiens)
REACT:R-MMU-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Mus musculus)
REACT:R-XTR-8932980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Xenopus tropicalis)
REACT:R-DRE-8851234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside triphosphates (Danio rerio)
REACT:R-SSC-6811522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Sus scrofa)
REACT:R-BTA-70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Bos taurus)
REACT:R-GGA-380283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Gallus gallus)
REACT:R-MMU-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Mus musculus)
RHEA:35769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine => dihydrosterigmatocystin + S-adenosyl-L-methionine
REACT:R-HSA-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Homo sapiens)
REACT:R-CFA-2730864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of TRAF6 to CBM complex by binding to MALT1 (Canis familiaris)
REACT:R-SSC-444731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Sus scrofa)
RHEA:51809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
RHEA:38174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecane-1,2-diol + hexadecanoyl-CoA <=> 2-hydroxyhexadecyl hexadecanoate + CoA
RHEA:14080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + L-alanine <=> beta-alanine + pyruvate
RHEA:58247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] <=> ADP-D-ribose + L-lysyl-[protein]
RHEA:30016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
REACT:R-DME-432556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO (Drosophila melanogaster)
RHEA:48045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)/18:0) + H2O => D-galactose + ganglioside GM2 (d18:1(4E)/18:0)
RHEA:35945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxybrevianamide E + diphosphate => brevianamide F + dimethylallyl diphosphate
RHEA:58805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-pApG-3' + H2O => 5'-ApG-3' + phosphate
RHEA:46870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli)
RHEA:33572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + methanol => AH2 + formaldehyde
REACT:R-HSA-376419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-MED1 Coactivator Complex (Homo sapiens)
RHEA:69181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + thiamine diphosphate => AMP + thiamine triphosphate
REACT:R-DRE-9716947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 agonists (Danio rerio)
REACT:R-CEL-198746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)
REACT:R-RNO-5633040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Rattus norvegicus)
REACT:R-BTA-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Bos taurus)
REACT:R-XTR-5684081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds CDK2 and RBBP8 (Xenopus tropicalis)
REACT:R-XTR-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Xenopus tropicalis)
REACT:R-BTA-5362500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)
RHEA:28838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + succinate(in) <=> citrate(in) + succinate(out)
RHEA:70011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzoyl-AMP + CoA = AMP + anthraniloyl-CoA + H(+)
RHEA:70117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:50979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D2(out) <=> prostaglandin D2(in)
REACT:R-CFA-9006873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT binding (Canis familiaris)
RHEA:36261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aldehyde + glycerol => a 1-(1-hydroxyalkyl)-sn-glycerol
GO:0033409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UAU codon-amino acid adaptor activity
GO:0033409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAT codon-amino acid adaptor activity
GO:0033409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tyrosine tRNA
GO:0101006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein histidine phosphatase activity
GO:0101006	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphohistidine phosphatase activity
REACT:R-SCE-418582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)
REACT:R-SCE-450494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HuR binds mRNAs in the nucleus (Saccharomyces cerevisiae)
RHEA:38260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-beta-methylmalyl-CoA => glyoxylate + propanoyl-CoA
RHEA:47850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + diphosphate + thiamine phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)
RHEA:67503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine
REACT:R-XTR-917839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-Transferrin dissociates from the receptor complex (Xenopus tropicalis)
RHEA:24149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-8951966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates RUNX3 (Homo sapiens)
RHEA:65405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + hexanoyl-CoA => butyl hexanoate + CoA
REACT:R-DRE-2089943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPC1 translocates calcium from the extracellular region to the cytosol (Danio rerio)
REACT:R-XTR-201669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin translocates to the nucleus (Xenopus tropicalis)
REACT:R-GGA-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Gallus gallus)
REACT:R-HSA-5689317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the pre-incision complex in GG-NER (Homo sapiens)
REACT:R-CFA-3928654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin internalises EPH:EFN complexes (Canis familiaris)
GO:0106277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin reductase (NADP+) activity
RHEA:28087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 + Reactive Blue 5 => 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate
RHEA:45705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapyl alcohol + NADP(+) => (E)-sinapaldehyde + H(+) + NADPH
RHEA:45609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine
RHEA:26435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole + L-serine => H2O + L-tryptophan
RHEA:44657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
GO:0017025	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TATA-binding protein binding
GO:0017025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBP-class protein binding
GO:0017025	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TBP-related factor (TRF) protein binding
GO:0017025	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	TBP binding
REACT:R-HSA-5669240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLNA binds PAK1 (Homo sapiens)
REACT:R-HSA-3209111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)
REACT:R-BTA-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Bos taurus)
REACT:R-MMU-2031355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)
RHEA:32856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine
REACT:R-HSA-6805285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates TP53 (Homo sapiens)
RHEA:11967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol
REACT:R-DRE-1605723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) (Danio rerio)
REACT:R-CFA-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Canis familiaris)
REACT:R-RNO-5694413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC4C,D bind GOSR2 and STX5 (Rattus norvegicus)
GO:0005244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated ion channel activity
GO:0005244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-dependent ion channel activity
GO:0005244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage gated ion channel activity
REACT:R-RNO-8953461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Rattus norvegicus)
REACT:R-HSA-2018682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Homo sapiens)
REACT:R-DRE-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Danio rerio)
RHEA:43976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + NADPH + O2 = 14-hydroxyhexadecanoate + H2O + NADP(+)
RHEA:42818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol
REACT:R-SSC-5205822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1 methylates arginine-18 (H3R17) of histone H3 (Sus scrofa)
RHEA:52165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-6809810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Bos taurus)
RHEA:14718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-erythrose 4-phosphate + H2O + phosphoenolpyruvate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate
REACT:R-RNO-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)
REACT:R-CFA-5682965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Canis familiaris)
RHEA:68770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine => 4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine
REACT:R-HSA-1295634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is serine phosphorylated in response to MAPK activation (Homo sapiens)
RHEA:58954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rh1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose
REACT:R-DDI-1855230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Dictyostelium discoideum)
REACT:R-DRE-5696457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDH2 dehydrogenates 3HBA (Danio rerio)
RHEA:18536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-L-tryptophan + H(+) <=> CO2 + serotonin
RHEA:12974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP => 2 ADP
GO:0004739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
GO:0004739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate dehydrogenase complex activity
GO:0004739	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MtPDC (mitochondrial pyruvate dehydogenase complex) activity
GO:0004739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate dehydrogenase (lipoamide) activity
GO:0004739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate dehydrogenase (acetyl-transferring) activity
GO:0004739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
GO:0004739	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PDH
RHEA:29533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
REACT:R-HSA-8944262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type X (Homo sapiens)
RHEA:27343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H(+) + H2O + hydroxylamine => AH2 + NH4(+) + O2
REACT:R-BTA-6800298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF dimer binds MET (Bos taurus)
RHEA:28795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH
RHEA:71268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-pipecolate(out) + 2 Na(+)(out) => chloride(in) + L-pipecolate(in) + 2 Na(+)(in)
REACT:R-BTA-9623384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-agonists bind ADRA1A,B,D (Bos taurus)
RHEA:62586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-tyrosine(in) + phosphate => ATP + H2O + L-tyrosine(out)
REACT:R-GGA-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Gallus gallus)
RHEA:51603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:44075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycerol + ATP <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DME-5654157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR2 (Drosophila melanogaster)
RHEA:27420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome] + H2O + nicotinate <=> 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)
REACT:R-HSA-5096488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRP8 binds RNA (Homo sapiens)
REACT:R-HSA-6785244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP11B2 does not oxidise 18HCORST (Homo sapiens)
REACT:R-MMU-392053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS binds Grb2 bound to pFAK:NCAM1 (Mus musculus)
REACT:R-GGA-3225851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize thioredoxin and activate MAP3K5 (Gallus gallus)
RHEA:56114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-nonaprenylphenol + H(+) + NADPH + O2
REACT:R-DRE-5654714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
REACT:R-BTA-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)
REACT:R-MMU-68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Mus musculus)
RHEA:72808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(out) => L-histidine(in)
REACT:R-CEL-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)
REACT:R-SSC-9753676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1,2 acetylate APAP-Cys to APAP-Mer (Sus scrofa)
EC:3.1.21.5	skos:prefLabel	"type III site-specific deoxyribonuclease"
EC:3.1.21.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"type III site-specific deoxyribonuclease"
EC:3.1.21.5	skos:altLabel	"type III restriction enzyme"
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	equilase activity
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	optidase activity
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catalase-peroxidase activity
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	heme catalase activity
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bacterial catalase-peroxidase activity
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CAT
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalase activity
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	haem catalase activity
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	manganese catalase activity
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catalase reaction
GO:0004096	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caperase activity
RHEA:59245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)
GO:0090369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine carbamoyltransferase inhibitor activity
REACT:R-CEL-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Caenorhabditis elegans)
RHEA:46433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:22015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-4 + S-adenosyl-L-methionine <=> precorrin-5 + S-adenosyl-L-homocysteine
RHEA:18412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH
RHEA:69911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(out) + 2 Na(+)(out) = adenosine(in) + 2 Na(+)(in)
EC:3.4.24.53	skos:altLabel	"proteinase H2"
EC:3.4.24.53	skos:altLabel	"Trimeresurus metalloendopeptidase II"
EC:3.4.24.53	skos:prefLabel	"trimerelysin II"
EC:3.4.24.53	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trimerelysin II"
RHEA:70483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 = a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate
RHEA:45339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine <=> [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA
REACT:R-BTA-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Bos taurus)
REACT:R-BTA-5621366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds to p-Y65,Y76-FCER1G (Bos taurus)
REACT:R-GGA-1678944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Gallus gallus)
GO:0047695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoin aldolase activity
GO:0047695	skos:altLabel	"2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase"
GO:0047695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzaldehyde lyase activity
GO:0047695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzoin aldolase"
GO:0047695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphenylethanone benzaldehyde-lyase activity
GO:0047695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity
GO:0047695	skos:prefLabel	"benzoin aldolase"
GO:0047695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)
GO:0047695	skos:altLabel	"benzaldehyde lyase"
GO:0047695	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity
GO:0047695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoin = 2 benzaldehyde
REACT:R-DME-433089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOAT can transport taurolithocholate-3-sulphate (Drosophila melanogaster)
RHEA:42703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-[ACP] methyl ester + H2O <=> 6-carboxyhexanoyl-[ACP] + H(+) + methanol
RHEA:16671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + urate => H2O + NAD(+) + xanthine
REACT:R-DRE-374787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPCR neuropeptide receptor binds neuropeptides B and W (Danio rerio)
REACT:R-MMU-1250315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB4 homodimers (Mus musculus)
REACT:R-HSA-72635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF4F binds to mRNP (Homo sapiens)
REACT:R-HSA-919404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT5 is released (Homo sapiens)
REACT:R-CFA-190519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of gap junction plaques (Canis familiaris)
GO:0042285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylosyltransferase activity
REACT:R-HSA-9700266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR F508del binds CFTR correctors (Homo sapiens)
REACT:R-RNO-5654622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
REACT:R-CEL-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
RHEA:28345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dITP + H2O <=> dIMP + diphosphate + H(+)
REACT:R-HSA-6804996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p14ARF sequesters MDM2 (Homo sapiens)
RHEA:32124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(in) + H(+)(in) => citrate(out) + H(+)(out)
REACT:R-DME-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Drosophila melanogaster)
EC:1.4.1.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate dehydrogenase"
EC:1.4.1.21	skos:altLabel	"NADH2-dependent aspartate dehydrogenase"
EC:1.4.1.21	skos:altLabel	"NAD-dependent aspartate dehydrogenase"
EC:1.4.1.21	skos:altLabel	"NADP(+)-dependent aspartate dehydrogenase"
EC:1.4.1.21	skos:prefLabel	"aspartate dehydrogenase"
RHEA:65197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine => H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine
REACT:R-SSC-2395873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Sus scrofa)
REACT:R-HSA-8949609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)
RHEA:38052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA => 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
REACT:R-RNO-9627104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP3 (Rattus norvegicus)
RHEA:29667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O(in) = H2O(out)
REACT:R-XTR-9757686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDL (Xenopus tropicalis)
REACT:R-HSA-8933446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Homo sapiens)
REACT:R-GGA-5685366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y-SHC (Gallus gallus)
REACT:R-XTR-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Xenopus tropicalis)
REACT:R-BTA-2509831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses XTP to XMP (Bos taurus)
REACT:R-DRE-3928625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAKs autophosphorylate (Danio rerio)
REACT:R-MMU-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Mus musculus)
REACT:R-RNO-4608852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 ubiquitinates PRICKLE1 (Rattus norvegicus)
REACT:R-MMU-5423672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2, 3A4 oxidise AFB1 to AFNBO (Mus musculus)
RHEA:43799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-CEL-1678842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Competitive inhibition of translation initiation by ISGylated 4EHP (Caenorhabditis elegans)
RHEA:19118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dopamine + 2 L-ascorbate + O2 => (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical
REACT:R-GGA-5685341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex stabilizes RAD51 filament (Gallus gallus)
REACT:R-DRE-4570489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO2 (Danio rerio)
REACT:R-CFA-6784204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAKs bind OSMR (Canis familiaris)
REACT:R-RNO-9018807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GDIs block activation of RAC3 (Rattus norvegicus)
REACT:R-XTR-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)
REACT:R-SCE-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Saccharomyces cerevisiae)
REACT:R-HSA-3782637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC8 deacetylates histones (Homo sapiens)
REACT:R-MMU-191323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)
RHEA:71934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(out) + 3 Na(+)(out) <=> fumarate(in) + 3 Na(+)(in)
GO:0102718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIBOA-glucoside methyltransferase activity
RHEA:59568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + ATP + L-histidine = ADP + H(+) + L-homocarnosine + phosphate
REACT:R-MMU-8853444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKA phosphorylates PHLDA1 (Mus musculus)
RHEA:13803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 H(+) + 3 NADPH + sulfite => 3 H2O + hydrogen sulfide + 3 NADP(+)
RHEA:50792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = aldosterone + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:20969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arabinonate => 2-dehydro-3-deoxy-L-arabinonate + H2O
RHEA:13943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glyceraldehyde 3-phosphate + H(+) => ATP + D-glyceraldehyde
RHEA:37039	skos:prefLabel	"heme oxygenase (staphylobilin-producing)"
RHEA:37039	skos:altLabel	"heme oxidase"
RHEA:37039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heme oxygenase (staphylobilin-producing)"
RHEA:37039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O
RHEA:37039	skos:altLabel	"heme oxygenase (decyclizing)"
RHEA:37039	skos:altLabel	"heme oxygenase"
RHEA:37039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O
REACT:R-BTA-9018017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Bos taurus)
GO:0050017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyanoalanine synthase activity
GO:0050017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)
GO:0050017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-3-cyanoalanine synthase"
GO:0050017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyano-L-alanine synthase activity
GO:0050017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-3-cyanoalanine synthase activity
GO:0050017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine hydrogen-sulfide-lyase (adding HCN)
GO:0050017	skos:prefLabel	"L-3-cyanoalanine synthase"
GO:0050017	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-cyanoalanine synthetase activity
GO:0050017	skos:altLabel	"beta-cyano-L-alanine synthase"
GO:0050017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + H(+) + hydrogen sulfide
GO:0050017	skos:altLabel	"beta-cyanoalanine synthase"
REACT:R-CEL-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Caenorhabditis elegans)
GO:0032356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidised DNA binding
GO:0032356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized DNA binding
REACT:R-DRE-109857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 binds MAPK3 (Danio rerio)
REACT:R-DME-2730847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
RHEA:35426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP
RHEA:48443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
REACT:R-RNO-549241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Rattus norvegicus)
RHEA:50186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2
REACT:R-MMU-5654643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)
REACT:R-MMU-8876319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC50A1 transports Glc from cytosol to extracellular region (Mus musculus)
REACT:R-DRE-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Danio rerio)
REACT:R-BTA-8987266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Bos taurus)
RHEA:53261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0015407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent monosaccharide transmembrane transporter activity
GO:0015407	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	monosaccharide ABC transporter
GO:0015407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monosaccharide-transporting ATPase activity
GO:0015407	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	monosaccharide-importing ATPase activity
GO:0015407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled monosaccharide transmembrane transporter activity
GO:0015407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type monosaccharide transporter activity
REACT:R-MMU-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Mus musculus)
REACT:R-CFA-2314678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS1 (Canis familiaris)
REACT:R-CFA-9693347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds 5HT (Canis familiaris)
REACT:R-MMU-2730851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Mus musculus)
REACT:R-XTR-2172433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIX degradation (Xenopus tropicalis)
RHEA:57247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP <=> dGTP + H(+) + lactate
REACT:R-SPO-9664867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds MAP1LC3B (Schizosaccharomyces pombe)
REACT:R-RNO-5696049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPRM hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)
REACT:R-SSC-141423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the MCC complex to the APC/C complex (Sus scrofa)
REACT:R-DRE-4088134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates FOXM1 (Danio rerio)
REACT:R-RNO-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)
RHEA:37066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9698174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 mutants recruit PIK3CA through PIK3R1 (Homo sapiens)
RHEA:17161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)
RHEA:17161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + salicylate
RHEA:17161	skos:prefLabel	"2,6-dioxo-6-phenylhexa-3-enoate hydrolase"
RHEA:17161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,6-dioxo-6-phenylhexa-3-enoate hydrolase"
RHEA:17161	skos:altLabel	"HOHPDA hydrolase"
RHEA:69599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + inosine <=> adenosine + IMP
REACT:R-HSA-9036290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan (Homo sapiens)
REACT:R-RNO-6791223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Rattus norvegicus)
REACT:R-DRE-975629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11 reduces RBP2:atRAL to RBP2:atROL (Danio rerio)
REACT:R-HSA-5140747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)
REACT:R-BTA-1640164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Bos taurus)
REACT:R-DME-6810410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)
RHEA:16747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-epoxyphylloquinone + A + H2O => AH2 + O2 + phylloquinone
REACT:R-BTA-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Bos taurus)
REACT:R-CEL-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Caenorhabditis elegans)
REACT:R-MMU-141409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mad1 binds kinetochore (Mus musculus)
REACT:R-DRE-5690856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Danio rerio)
REACT:R-DRE-109863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK3:MAP2K1 (Danio rerio)
RHEA:57400	skos:prefLabel	"3-O-acetylpapaveroxine carboxylesterase"
RHEA:57400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-O-acetylpapaveroxine carboxylesterase"
RHEA:57400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-acetylpapaveroxine + H2O = acetate + H(+) + narcotine hemiacetal
RHEA:12097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-benzylformamide => benzylamine + formate
REACT:R-HSA-8983671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAS1 binds viral dsRNA (Homo sapiens)
RHEA:70635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:48751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threitol + NAD(+) <=> D-erythrulose + H(+) + NADH
RHEA:10058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-butenoyl-CoA + NH4(+) => (3S)-3-aminobutanoyl-CoA
GO:0016165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fat oxidase activity
GO:0016165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoxydase activity
GO:0016165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoperoxidase activity
GO:0016165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	linoleate:oxygen 13-oxidoreductase activity
GO:0016165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lionoleate:O2 oxidoreductase activity
GO:0016165	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lipoxygenase activity
GO:0016165	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lipoxidase activity
GO:0016165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	linoleate 13S-lipoxygenase activity
GO:0016165	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	carotene oxidase activity
REACT:R-GGA-158941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Gallus gallus)
REACT:R-DRE-9009488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 binds CSF1 (Danio rerio)
REACT:R-XTR-9627089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP9 is phosphorylated at T125 (Xenopus tropicalis)
REACT:R-CFA-5692749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC14A,B bind MAPK6 (Canis familiaris)
RHEA:11930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + hydrazine => hydroxylamine + NH4(+)
REACT:R-XTR-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Xenopus tropicalis)
RHEA:53154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-77340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Mus musculus)
REACT:R-MMU-177924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Gab1 by SHP2 (Mus musculus)
RHEA:52386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate => L-glutamate + O-phospho-L-serine
RHEA:19351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3,3-dimethylmalate + 2 H(+) + NADH => (R)-4-dehydropantoate + H2O + NAD(+)
RHEA:58162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + dolabradiene => ent-copalyl diphosphate
RHEA:67615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP
EC:5.3.4.1	skos:prefLabel	"protein disulfide-isomerase"
EC:5.3.4.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein disulfide-isomerase"
EC:5.3.4.1	skos:altLabel	"S-S rearrangase"
REACT:R-HSA-1791154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GOSR2 (Homo sapiens)
RHEA:49461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-aminomuconate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)
RHEA:31884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => delta-amyrin
REACT:R-GGA-561041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT1-3 transport organic anions with antiport of dicarboxylic acids (Gallus gallus)
REACT:R-SSC-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Sus scrofa)
REACT:R-XTR-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Xenopus tropicalis)
RHEA:33197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA
RHEA:66339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(out) <=> L-glutamate(in)
RHEA:51953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylphenol + H2O + 2 oxidized [azurin] = 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]
REACT:R-RNO-5693533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C (ARTEMIS) processes DNA DSB ends (Rattus norvegicus)
GO:0050338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate:ferricytochrome-c oxidoreductase activity
GO:0050338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate oxidase activity
GO:0050338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate dehydrogenase activity
GO:0050338	skos:prefLabel	"thiosulfate dehydrogenase"
GO:0050338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulphate dehydrogenase activity
GO:0050338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + 2 thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate
GO:0050338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate-oxidizing enzyme
GO:0050338	skos:altLabel	"tetrathionate synthase"
GO:0050338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiosulfate dehydrogenase"
GO:0050338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrathionate synthase activity
GO:0050338	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiosulfate-acceptor oxidoreductase activity
REACT:R-GGA-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Gallus gallus)
REACT:R-GGA-75081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC B Complex (Gallus gallus)
REACT:R-SSC-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Sus scrofa)
REACT:R-DME-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)
GO:0019976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-2 binding
GO:0019976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-2 binding
RHEA:53660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate
RHEA:17184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty aldehyde + FMNH2 + O2 <=> a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu
REACT:R-SSC-5668534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Sus scrofa)
RHEA:18783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + CO2 => H(+) + malonyl-CoA
GO:0016774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphotransferase activity, carboxyl group as acceptor
RHEA:63069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2 H(+) + 2 malonyl-CoA => 2 CO2 + 3 CoA + triacetate lactone
REACT:R-CEL-3928619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds RAC1:GTP (Caenorhabditis elegans)
REACT:R-MMU-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Mus musculus)
REACT:R-BTA-8851044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN1A1 binds xanthine oxidoreductase (XDH) (Bos taurus)
REACT:R-HSA-9707051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN1 binds BRCA1:BARD1 heterodimer (Homo sapiens)
REACT:R-CEL-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Caenorhabditis elegans)
REACT:R-BTA-3239014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates TP53 (Bos taurus)
RHEA:72312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(in) + taurocholate(out) => glutathione(out) + taurocholate(in)
REACT:R-SSC-8853800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARTN binds RET:GFRA1,GFRA3 (Sus scrofa)
RHEA:71205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoarginine(out) => L-homoarginine(in)
REACT:R-MMU-420243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHRH receptor binds GHRH (Mus musculus)
REACT:R-BTA-5651828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARG dePARylates PARP1,PARP2 (Bos taurus)
REACT:R-HSA-2396234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VII binds laminin-322 and collagen IV (Homo sapiens)
REACT:R-SCE-204617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Saccharomyces cerevisiae)
REACT:R-BTA-8933328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYPLA2 hydrolyses PALM-C3,4-GAP43 (Bos taurus)
RHEA:66530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-(5'-adenylyl)-L-tyrosyl-[protein]
RHEA:47687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->2)-beta-D-glucosyl](n) + phosphate <=> [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
REACT:R-RNO-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Rattus norvegicus)
REACT:R-RNO-170072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Rattus norvegicus)
REACT:R-SSC-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Sus scrofa)
RHEA:30821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + H(+) => allantoin + H2O
REACT:R-SSC-8852306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Sus scrofa)
REACT:R-HSA-8964287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (s):GTP:SRC dissociates (Homo sapiens)
REACT:R-DRE-8852351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 promotes translocation of TP53 to the cytosol (Danio rerio)
RHEA:52234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + Fe(2+) + 3 H2O + mycobilin a => 3 AH2 + 2 H(+) + heme b + 3 O2
REACT:R-DME-2529015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of CK2-modified condensin I (Drosophila melanogaster)
REACT:R-HSA-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
REACT:R-HSA-5173192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POFUT2 transfers fucose to TSR domain-containing proteins (Homo sapiens)
REACT:R-RNO-391152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47 binds PTK2B (Rattus norvegicus)
RHEA:22514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogenobyrinate => 3 H(+) + precorrin-8X
REACT:R-DRE-8875482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL recruits CIN85:endophilin to ubiquitinated MET (Danio rerio)
GO:0030623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	U5 snRNA binding
GO:0018638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toluene 4-monooxygenase activity
RHEA:59029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-RNO-2213208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type X collagen associates with collagen type II fibrils (Rattus norvegicus)
RHEA:33271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)
RHEA:28165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine + GTP <=> CMP + GDP + H(+)
REACT:R-CFA-8864278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-2 (TFAP2) transcription factors form homo- and heterodimers (Canis familiaris)
REACT:R-RNO-8875540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 recruits CRK,CRKL to MET (Rattus norvegicus)
RHEA:48973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + phosphite(out) => ADP + H(+) + phosphate + phosphite(in)
REACT:R-MMU-2730840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Mus musculus)
GO:0090555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylethanolamine flippase activity
GO:0090555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate
GO:0090555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylethanolamine-translocating ATPase activity
GO:0090555	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent phosphatidylethanolamine transporter activity
GO:0090555	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATPase-coupled phosphatidylethanolamine transporter activity
GO:0090555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)
RHEA:36775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
RHEA:36775	skos:prefLabel	"UDP-Gal:alpha-L-Fuc-1,2-beta-Gal-1,3-alpha-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase"
RHEA:36775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-Gal:alpha-L-Fuc-1,2-beta-Gal-1,3-alpha-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase"
RHEA:24460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malonyl-S-ACP decarboxylase"
RHEA:24460	skos:prefLabel	"malonyl-S-ACP decarboxylase"
RHEA:24460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] = acetyl-[ACP] + CO2
RHEA:24460	skos:altLabel	"malonyl-S-acyl-carrier protein decarboxylase"
REACT:R-RNO-9624527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Rattus norvegicus)
REACT:R-SSC-3247839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retromer associates with WLS (Sus scrofa)
RHEA:12483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate + pyruvate <=> 4,5-dioxopentanoate + L-alanine
RHEA:38707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol
RHEA:54280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate
REACT:R-DME-2730844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of GRB2:SOS complex with p-SHC1 (Drosophila melanogaster)
REACT:R-RNO-352191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A8-mediated uptake of neutral amino acids (Rattus norvegicus)
REACT:R-BTA-193705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)
REACT:R-XTR-5661116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM5A-D demethylate Me3K5-histone H3 (Xenopus tropicalis)
RHEA:54884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + NADP(+) = H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
REACT:R-SCE-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Saccharomyces cerevisiae)
REACT:R-MMU-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Mus musculus)
REACT:R-RNO-8850529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RGS proteins bind GNB5 and CCT/TRiC (Rattus norvegicus)
REACT:R-DDI-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Dictyostelium discoideum)
RHEA:54658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol => linalool
REACT:R-DRE-376364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp8 associated secretory vesicle to plasma membrane transport (Danio rerio)
REACT:R-MMU-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Mus musculus)
RHEA:46491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)
REACT:R-GGA-936564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRX1 inhibits MAVS-DDX58 interaction. (Gallus gallus)
RHEA:32805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + urea(in) => ATP + H2O + urea(out)
REACT:R-SSC-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Sus scrofa)
GO:0050276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	scyllo-inosamine kinase (phosphorylating)
GO:0050276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inosamine kinase activity
GO:0050276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity
GO:0050276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scyllo-inosamine 4-kinase activity
GO:0050276	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:inosamine phosphotransferase activity
RHEA:23338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diiodine + 2 H2O => 2 H(+) + H2O2 + 2 iodide
RHEA:65707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose <=> alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)
REACT:R-DRE-975185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Danio rerio)
REACT:R-HSA-8849345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Homo sapiens)
RHEA:23329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 9-cis-epoxycarotenoid + O2 => 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal
RHEA:58434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-oxonon-2-enal + H(+) + NADPH => (E)-4-oxonon-2-en-1-ol + NADP(+)
REACT:R-SSC-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Sus scrofa)
EC:3.2.1.48	skos:altLabel	"sucrase"
EC:3.2.1.48	skos:prefLabel	"sucrose alpha-glucosidase"
EC:3.2.1.48	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sucrose alpha-glucosidase"
EC:3.2.1.48	skos:altLabel	"sucrase-isomaltase"
EC:3.2.1.48	skos:altLabel	"sucrose alpha-glucohydrolase"
RHEA:16305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)
RHEA:16305	skos:prefLabel	"hydroxymethylglutaryl-CoA hydrolase"
RHEA:16305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxymethylglutaryl-CoA hydrolase"
RHEA:69482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine
GO:0046994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor
GO:0046994	skos:prefLabel	"With a quinone or similar compound as acceptor"
GO:0046994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
GO:0004059	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:2-arylethylamine N-acetyltransferase activity
GO:0004059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serotonin acetylase activity
GO:0004059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aralkylamine N-acetyltransferase activity
GO:0004059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serotonin N-acetyltransferase activity
GO:0004059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	serotonin acetyltransferase activity
GO:0004059	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylalkylamine N-acetyltransferase activity
GO:0004059	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AANAT activity
GO:0004059	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	melatonin rhythm enzyme activity
GO:0102064	skos:prefLabel	"gamma-curcumene synthase"
GO:0102064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-curcumene synthase"
GO:0102064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + gamma-curcumene
GO:0102064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-curcumene synthase activity
RHEA:30798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + CoA + NAD(+) <=> CO2 + glutaryl-CoA + NADH
RHEA:39011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)
REACT:R-XTR-8848829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL autoubiquitinates (Xenopus tropicalis)
RHEA:64895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[ACP] + tetradecanoyl-AMP <=> AMP + H(+) + tetradecanoyl-[ACP]
RHEA:64612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + tRNA(Gln) = AMP + diphosphate + L-glutamyl-tRNA(Gln)
RHEA:62614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine => adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine
REACT:R-HSA-5672017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rheb in the MTORC1 complex hydrolyses GTP (Homo sapiens)
EC:3.2.2.17	skos:altLabel	"pyrimidine dimer DNA-glycosylase"
EC:3.2.2.17	skos:prefLabel	"deoxyribodipyrimidine endonucleosidase"
EC:3.2.2.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"deoxyribodipyrimidine endonucleosidase"
REACT:R-MMU-5669240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLNA binds PAK1 (Mus musculus)
REACT:R-MMU-418172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB2 (Mus musculus)
RHEA:33005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-8952630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
REACT:R-BTA-8987052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dimer translocates from cytosol to nucleoplasm (Bos taurus)
RHEA:46563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
GO:0033992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-fructose 4-dehydratase activity
GO:0033992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-fructose hydrolyase activity
GO:0033992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AFDH
GO:0033992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-fructose hydro-lyase activity
GO:0033992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity
GO:0033992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AF dehydratase activity
GO:0033992	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity
GO:0033992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose dehydratase activity
REACT:R-RNO-1606602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) (Rattus norvegicus)
REACT:R-RNO-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Rattus norvegicus)
REACT:R-DRE-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)
REACT:R-HSA-708349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD2 oligomerizes (Homo sapiens)
REACT:R-HSA-9020264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Homo sapiens)
REACT:R-BTA-6787820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds CSF1R (Bos taurus)
RHEA:18573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + H(+) + O2 = chelirubine + H2O2
REACT:R-HSA-76475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Homo sapiens)
RHEA:14704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CoA + NAD(+) <=> CoA-disulfide + H(+) + NADH
RHEA:20010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose => H(+) + linamarin + UDP
RHEA:61579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) <=> (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH
REACT:R-SSC-5690046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPT2 hydrolyses PALMCoA to PALM (Sus scrofa)
REACT:R-DME-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Drosophila melanogaster)
REACT:R-HSA-9617660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROS oxidize FOXO4 cysteine residues (Homo sapiens)
RHEA:25373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(1-carboxyvinyloxy)anthranilate + FMNH2 => (2S)-2-amino-4-deoxychorismate + FMN
REACT:R-SPO-5336466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)
RHEA:18104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydro-3-ethylcatechol + NAD(+) <=> 3-ethylcatechol + H(+) + NADH
REACT:R-MMU-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Mus musculus)
RHEA:68950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + scopoletin => esculetin + S-adenosyl-L-methionine
REACT:R-CFA-74746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-Y427-SHC1 (Canis familiaris)
REACT:R-HSA-2263490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate (Homo sapiens)
RHEA:55279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol + tetradecanoyl-CoA <=> 9-cis-retinyl tetradecanoate + CoA
RHEA:56329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O => 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)
REACT:R-HSA-1234167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)
REACT:R-MMU-9686920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 ubiquitinates RIPK3 at K363 (Mus musculus)
RHEA:44746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O => 4 H(+) + 4 malonyl-CoA
REACT:R-CEL-8847995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERBB2 binds PTK6 (BRK) (Caenorhabditis elegans)
RHEA:25691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) => CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate
REACT:R-XTR-4086088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO1 (Xenopus tropicalis)
REACT:R-MMU-176646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Mus musculus)
REACT:R-MMU-8852306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Mus musculus)
REACT:R-DME-209193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AP-1, Phospho JRA:Phospho KAY dissociates from CKA (Drosophila melanogaster)
RHEA:26446	skos:altLabel	"NADP-dependent malonyl CoA reductase"
RHEA:26446	skos:prefLabel	"malonyl CoA reductase (malonate semialdehyde-forming)"
RHEA:26446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malonyl CoA reductase (malonate semialdehyde-forming)"
RHEA:26446	skos:altLabel	"malonyl CoA reductase (NADP)"
RHEA:26446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + CoA + NADP(+) = H(+) + malonyl-CoA + NADPH
RHEA:26032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:11030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-mannose 6-phosphate + H(+) => ATP + D-mannose
RHEA:27693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dGDP <=> ADP + dGTP
REACT:R-DRE-5610742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI1 (Danio rerio)
REACT:R-DRE-4615910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PCNA with SUMO1 (Danio rerio)
REACT:R-BTA-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Bos taurus)
RHEA:46334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-DME-158441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)
REACT:R-HSA-9769418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 stimulates RET gene expression (Homo sapiens)
RHEA:67464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + propanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine
REACT:R-SSC-1602454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proMMP9 binds TIMP1 (Sus scrofa)
REACT:R-MMU-72619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF2:GTP is hydrolyzed, eIFs are released  (Mus musculus)
REACT:R-BTA-936985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TLR4:TICAM1 recruits TRAF6 (Bos taurus)
GO:0050578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity
GO:0050578	skos:prefLabel	"D-2-hydroxyacid dehydrogenase (NADP(+))"
GO:0050578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-sulfolactate:NAD(P)(+) oxidoreductase activity
GO:0050578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-sulfolactate:NAD(P)+ oxidoreductase activity
GO:0050578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyacid dehydrogenase activity
GO:0050578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-2-hydroxyacid dehydrogenase (NADP(+))"
GO:0050578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-sulfolactate dehydrogenase activity
REACT:R-CEL-71723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Caenorhabditis elegans)
REACT:R-BTA-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
REACT:R-XTR-8849032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS2 (Xenopus tropicalis)
REACT:R-XTR-917811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3-like proteins reduce Fe3+ to Fe2+ (Xenopus tropicalis)
RHEA:51343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate
REACT:R-HSA-9694447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA2 is translated to Spike (Homo sapiens)
REACT:R-XTR-8944214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type I (Xenopus tropicalis)
REACT:R-HSA-9021325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter (Homo sapiens)
RHEA:32186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + O2 <=> cholest-5-en-3-one + H2O2
RHEA:17968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) <=> (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O
REACT:R-HSA-1791088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of GFPT1 (Homo sapiens)
REACT:R-XTR-70560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl phosphate + ornithine => citrulline + orthophosphate (Xenopus tropicalis)
REACT:R-CFA-420580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:PVRL3 trans heterodimer formation (Canis familiaris)
REACT:R-CEL-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Caenorhabditis elegans)
REACT:R-SSC-9013438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the endosome membrane (Sus scrofa)
RHEA:70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-glutamine(in) + Na(+)(in) => L-arginine(in) + L-glutamine(out) + Na(+)(out)
REACT:R-XTR-2046097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Xenopus tropicalis)
GO:0033920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-beta-D-galactosidase activity
GO:0033920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-beta-galactosidase activity
GO:0033920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity
GO:0033920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phospho-beta-D-galactosidase activity
GO:0033920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-beta-galactosidase activity
GO:0033920	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-D-phosphogalactoside galactohydrolase activity
REACT:R-DDI-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Dictyostelium discoideum)
REACT:R-MMU-5684806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown kinase phosphorylates CLEC1B dimer:PDPN (Mus musculus)
REACT:R-MMU-4615873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates SUZ12 with SUMO1 (Mus musculus)
EC:4.1.1.106	skos:prefLabel	"fatty acid photodecarboxylase"
EC:4.1.1.106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty acid photodecarboxylase"
REACT:R-MMU-5683986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)
RHEA:12806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-canadine + S-adenosyl-L-methionine => (S)-N-methylcanadine + S-adenosyl-L-homocysteine
RHEA:45837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
REACT:R-BTA-109449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)
REACT:R-DRE-8876190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB8 GEFs exchange GTP for GDP on RAB8 (Danio rerio)
GO:0016819	skos:prefLabel	"In sulfonyl-containing anhydrides"
GO:0016819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides
GO:0016819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides
GO:0016819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"In sulfonyl-containing anhydrides"
REACT:R-SSC-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
GO:0030515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	snoRNA binding
REACT:R-MMU-202721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM2 binds JAM3 (Mus musculus)
RHEA:21772	skos:prefLabel	"mRNA(cytosine(6666)) deaminase"
RHEA:21772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mRNA(cytosine(6666)) deaminase"
RHEA:21772	skos:altLabel	"apolipoprotein B mRNA editing enzyme"
RHEA:21772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNA
REACT:R-RNO-171059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Rattus norvegicus)
REACT:R-CFA-166792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C2 into C2a and C2b (Canis familiaris)
RHEA:56919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH
REACT:R-RNO-5607723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Rattus norvegicus)
RHEA:19547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + phosphocholine => H2O + sn-glycerol 3-phosphocholine
RHEA:28060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-xylulose => L-lyxopyranose
REACT:R-HSA-9656213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)
REACT:R-HSA-880050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)
REACT:R-BTA-9012761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI binds RHOA-GDI (Bos taurus)
REACT:R-SSC-8850326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds self-lipid-based antigen via CD1 (Sus scrofa)
REACT:R-SPO-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Schizosaccharomyces pombe)
RHEA:61309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-8987129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Canis familiaris)
RHEA:47890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
RHEA:13303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycerol + a sterol ester => a 1,2-diacyl-sn-glycerol + a sterol
RHEA:12278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => 3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
GO:0046547	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity
GO:0046547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-aconitate 3-methyltransferase activity
REACT:R-CFA-9009485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34:CSF1 binds CSF1R (Canis familiaris)
REACT:R-BTA-6807053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)
RHEA:10172	skos:prefLabel	"hydroxybutyrate-dimer hydrolase"
RHEA:10172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxybutyrate-dimer hydrolase"
RHEA:10172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+)
REACT:R-HSA-8878178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter (Homo sapiens)
RHEA:20356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chloride + H(+) + trichloroethene <=> AH2 + tetrachloroethene
RHEA:56470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2
REACT:R-HSA-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)
REACT:R-MMU-8871260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD2 (Mus musculus)
RHEA:71262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + phosphate(out) <=> 2 Na(+)(in) + phosphate(in)
RHEA:32251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH
RHEA:17499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ononin + UDP => formononetin + UDP-alpha-D-glucose
RHEA:20511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + O-phosphoviomycin => ATP + viomycin
REACT:R-XTR-5665998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 binds SRF (Xenopus tropicalis)
REACT:R-DRE-204824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Ang4 (Danio rerio)
REACT:R-GGA-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)
RHEA:34259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-larreatricin + AH2 + O2 = (+)-3'-hydroxylarreatricin + A + H2O
RHEA:34259	skos:prefLabel	"(+)-larreatricin hydroxylase"
RHEA:34259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-larreatricin hydroxylase"
REACT:R-CFA-170076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Canis familiaris)
REACT:R-DRE-9018907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Danio rerio)
REACT:R-DRE-174251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Danio rerio)
REACT:R-HSA-4088338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective GNE does not hydrolyse UDP-GlcNAc (Homo sapiens)
RHEA:31143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH
REACT:R-DRE-2993799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates 6xMCCC1:6xMCCC2 (Danio rerio)
REACT:R-CEL-1483190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA and CTP are condensed to CDP-ETA by PCY2 (Caenorhabditis elegans)
RHEA:23604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kievitone hydrate = H2O + kievitone
RHEA:23604	skos:prefLabel	"kievitone hydratase"
RHEA:23604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kievitone hydratase"
RHEA:71144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyhispidin + O2 => (E)-caffeoylpyruvate + CO2 + hnu
REACT:R-HSA-9608048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PLIN1 regulated by NR1H2 or NR1H3 (Homo sapiens)
RHEA:72439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + ATP + H(+) = (E)-feruloyl-AMP + diphosphate
REACT:R-XTR-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Xenopus tropicalis)
RHEA:67665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O => 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid
REACT:R-CFA-75079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of AT-AC C complex (Canis familiaris)
REACT:R-GGA-182993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of stimulated EGFR (CBL) (Gallus gallus)
RHEA:20798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose => aldehydo-D-ribose
RHEA:32224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-NADHX + ADP => AMP + H(+) + NADH + phosphate
RHEA:56396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)
REACT:R-SSC-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Sus scrofa)
REACT:R-DDI-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)
REACT:R-MMU-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Mus musculus)
RHEA:48338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose
REACT:R-SSC-3323050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNRD2 catalyzes the reduction of TXN2 by NADPH (Sus scrofa)
REACT:R-XTR-5686430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUS81 binds EME1, EME2 (Xenopus tropicalis)
RHEA:32573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylisoborneol + diphosphate => (E)-2-methylgeranyl diphosphate + H2O
RHEA:19359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O + N-methyl-L-proline + NADP(+) => H(+) + L-proline betaine + NADPH + O2
RHEA:10143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin D2
GO:0102531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysteroid-phosphate phosphatase activity
REACT:R-BTA-176604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Bos taurus)
REACT:R-BTA-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Bos taurus)
RHEA:47115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + glycine <=> glycochenodeoxycholate + H2O
GO:0018558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
REACT:R-MMU-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Mus musculus)
REACT:R-MMU-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Mus musculus)
GO:0062146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)
GO:0062146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chloro-allylglycine synthase activity
REACT:R-RNO-5654672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR1 (Rattus norvegicus)
REACT:R-HSA-4085021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Homo sapiens)
RHEA:15067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine + benzoate => H2O + N(4)-benzoylagmatine
RHEA:43579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate
REACT:R-GGA-3791149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Gallus gallus)
RHEA:56547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
RHEA:14962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-formylglutathione => formate + glutathione + H(+)
RHEA:42564	skos:altLabel	"pseudouridine synthase 3"
RHEA:42564	skos:prefLabel	"tRNA pseudouridine(38/39) synthase"
RHEA:42564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA pseudouridine(38/39) synthase"
RHEA:42564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA
REACT:R-CFA-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Canis familiaris)
GO:2001062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylan binding
RHEA:70812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate => D-xylulose 5-phosphate + sulfoacetaldehyde
REACT:R-BTA-5683831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCDC59 binds TTF1 (Bos taurus)
REACT:R-BTA-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Bos taurus)
REACT:R-MMU-1604350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14:TIMP2 binds proMMP2 (Mus musculus)
REACT:R-DRE-1237160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA is cleaved and phosphorylated (Danio rerio)
REACT:R-HSA-5661230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds arsenic (Homo sapiens)
REACT:R-HSA-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Homo sapiens)
REACT:R-HSA-9622737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO3,FOXO6,(FOXO1) binds CAT gene promoter (Homo sapiens)
RHEA:35598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzene-1,2,4-triol + O2 <=> 2 H(+) + maleylacetate
RHEA:38782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-HSA-9665286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resistant ERBB2 KD mutants do not bind neratinib (Homo sapiens)
REACT:R-HSA-8854628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLIP dimer ubiquitinates VLDLR on Lys-839 (Homo sapiens)
RHEA:37390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-XTR-352136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Xenopus tropicalis)
RHEA:34061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	didehydroagroclavine + H(+) + NADPH => agroclavine + NADP(+)
REACT:R-DRE-73722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of UBF-1:rDNA Promoter (Danio rerio)
REACT:R-RNO-9014456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOG (Rattus norvegicus)
REACT:R-BTA-72231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Cleavage and Polyadenylation Complex (Bos taurus)
RHEA:21488	skos:prefLabel	"beta-apiosyl-beta-glucosidase"
RHEA:21488	skos:altLabel	"isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase"
RHEA:21488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-apiosyl-beta-glucosidase"
RHEA:21488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)
RHEA:21488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)
RHEA:21488	skos:altLabel	"isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase"
RHEA:21488	skos:altLabel	"furcatin hydrolase"
RHEA:32220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-lycopene => gamma-carotene
REACT:R-XTR-416690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4A binds to PLXND1 (Xenopus tropicalis)
REACT:R-HSA-9756177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse ATVL to ATV (Homo sapiens)
REACT:R-CFA-1971491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Canis familiaris)
RHEA:61499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)
RHEA:42388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl crocetin + H(+) + UDP
RHEA:64272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylamine + pyruvate = benzaldehyde + L-alanine
REACT:R-SSC-2065355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)
REACT:R-SSC-2426450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins:Nidogens binds collagen type IV networks (Sus scrofa)
REACT:R-CFA-391155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRPA binds SFTPA oligomer, SFTPD oligomer (Canis familiaris)
REACT:R-DME-5666008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCAI binds SRF:MKL1 (Drosophila melanogaster)
RHEA:40824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate
RHEA:61936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cycloheximide(in) + H2O = ADP + cycloheximide(out) + H(+) + phosphate
REACT:R-HSA-9710295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF2 or IRF1 binds the GSDMD gene promoter (Homo sapiens)
REACT:R-RNO-8853745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET binds GFRA1,GFRA3 (Rattus norvegicus)
RHEA:13075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 3',5'-bis(diphosphate) + H(+) + phosphate => guanosine 3'-diphosphate 5'-triphosphate + H2O
RHEA:47458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+)
GO:0050245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercitrinase activity
GO:0050245	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quercitrin 3-L-rhamnohydrolase activity
RHEA:25432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-ribose pyranase"
RHEA:25432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-ribopyranose = beta-D-ribofuranose
RHEA:25432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-allofuranose = beta-D-allopyranose
RHEA:25432	skos:prefLabel	"D-ribose pyranase"
EC:3.4.22.45	skos:altLabel	"HC-Pro"
EC:3.4.22.45	skos:prefLabel	"helper-component proteinase"
EC:3.4.22.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"helper-component proteinase"
GO:0034809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity
REACT:R-BTA-428696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Bos taurus)
REACT:R-CEL-209921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoiodinated tyrosine can be deiodinated (Caenorhabditis elegans)
REACT:R-CEL-2028635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Caenorhabditis elegans)
REACT:R-XTR-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Xenopus tropicalis)
RHEA:40238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme B + coenzyme M + fumarate <=> coenzyme M-coenzyme B heterodisulfide + succinate
REACT:R-XTR-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Xenopus tropicalis)
REACT:R-RNO-212614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamine transport from astrocytes (Rattus norvegicus)
REACT:R-RNO-5607004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble PROCR binds PRTN3:CD177 (Rattus norvegicus)
RHEA:25488	skos:altLabel	"(-)-alpha-pinene cyclase"
RHEA:25488	skos:prefLabel	"(-)-alpha-pinene synthase"
RHEA:25488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-alpha-pinene synthase"
RHEA:25488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (1S,5S)-alpha-pinene + diphosphate
RHEA:25488	skos:altLabel	"(-)-alpha-pinene/(-)-camphene synthase"
EC:1.98.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Other oxidoreductases"
EC:1.98.1.-	skos:prefLabel	"Other oxidoreductases"
RHEA:44483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-200424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Caenorhabditis elegans)
GO:0140858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone ubiquitin ligase activity (H2A-K15 specific)
GO:0140858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H2AK15 ubiquitin ligase activity
REACT:R-CFA-8878664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A4 cotransports Na+ with 3HCO3- (Canis familiaris)
REACT:R-DRE-159566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Danio rerio)
GO:0102624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	scutellarein 7-methyl ether 4'-O-methyltransferase activity
REACT:R-CEL-3322057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Caenorhabditis elegans)
RHEA:69182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + thiamine triphosphate => ADP + thiamine diphosphate
REACT:R-DRE-2730882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC-theta (Danio rerio)
REACT:R-DME-3928642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
RHEA:64223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine
REACT:R-SSC-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Sus scrofa)
RHEA:14818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-maleylacetoacetate => 4-fumarylacetoacetate
REACT:R-MMU-198824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Mus musculus)
RHEA:12072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (S)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)
REACT:R-BTA-4084999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU1 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)
RHEA:41686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O
RHEA:26438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH
RHEA:26438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxypropionate dehydrogenase (NADP(+))"
RHEA:26438	skos:altLabel	"3-hydroxypropanoate dehydrogenase (NADP(+))"
RHEA:26438	skos:prefLabel	"3-hydroxypropionate dehydrogenase (NADP(+))"
REACT:R-GGA-8940100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates VCPIP1 (Gallus gallus)
RHEA:34080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP
REACT:R-DRE-140825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Danio rerio)
REACT:R-HSA-162729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Homo sapiens)
REACT:R-CFA-381503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP6 binds IGF forming IGF:IGFBP6 (Canis familiaris)
REACT:R-DME-6805507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APAF1 binds AVEN (Drosophila melanogaster)
REACT:R-MMU-9013110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC binds effectors at the plasma membrane (Mus musculus)
RHEA:65936	skos:prefLabel	"mannose 2-epimerase"
RHEA:65936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannose 2-epimerase"
RHEA:65936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-mannose = beta-D-glucose
REACT:R-DME-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Drosophila melanogaster)
REACT:R-XTR-186786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF beta receptors (Xenopus tropicalis)
RHEA:65730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + hexanal + succinate + sulfate => 2-oxoglutarate + hexyl sulfate + O2
EC:3.4.23.-	skos:prefLabel	"Aspartic endopeptidases"
EC:3.4.23.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Aspartic endopeptidases"
REACT:R-MMU-8948800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNKS and TNKS2 PARylate PTEN (Mus musculus)
RHEA:70196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + deamido-NAD(+) => ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate
RHEA:61572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoate + O2 = (15S)-hydroperoxy-(11Z,13E)-eicosadienoate
REACT:R-CFA-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Canis familiaris)
REACT:R-DDI-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)
REACT:R-GGA-2176445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD2 (Gallus gallus)
REACT:R-DME-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Drosophila melanogaster)
RHEA:42462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2',3-triol + NAD(+) => dibenzofuran + H(+) + NADH + O2
RHEA:48155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b(d18:1(4E)/18:0) + H2O <=> ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate
REACT:R-HSA-5218643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)
REACT:R-BTA-3222006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STK11 (LKB1) phosphorylates NUAK1 (Bos taurus)
RHEA:65969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate
RHEA:45847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctanoyl-CoA + NADP(+) <=> 3-oxooctanoyl-CoA + H(+) + NADPH
RHEA:38168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecan-1-ol + hexadecanoyl-CoA => CoA + hexadecanyl hexadecanoate
REACT:R-SPO-1482629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)
RHEA:49148	skos:prefLabel	"dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase"
RHEA:49148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase"
RHEA:49148	skos:altLabel	"TDP-4-amino-2,3,6-trideoxy-D-glucose N,N-dimethyltransferase"
RHEA:49148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine
RHEA:49846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl acid ketone + a quinol => (-)-dehydrodiconiferyl acid + a quinone
REACT:R-HSA-8863674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)
RHEA:19260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + NADP(+) <=> a ketone + H(+) + NADPH
REACT:R-CEL-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Caenorhabditis elegans)
REACT:R-RNO-9008052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10(?-152) binds IL1RAPL1 (Rattus norvegicus)
REACT:R-DRE-9638127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G6P to G1P (Danio rerio)
REACT:R-BTA-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Bos taurus)
GO:0030957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tat protein binding
REACT:R-DRE-9638078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from keratan sulfate (Danio rerio)
REACT:R-MMU-5667008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds RHPN1 or RHPN2 (Mus musculus)
REACT:R-DRE-5676592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xRANK binds RANKL,sRANKL trimer:RANK (Danio rerio)
RHEA:59699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotetraono-1,5-lactone + H2O <=> D-cellotetraonate + H(+)
REACT:R-RNO-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Rattus norvegicus)
RHEA:46932	skos:prefLabel	"2-epi-5-epi-valiolone 7-phosphate 2-epimerase"
RHEA:46932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-epi-5-epi-valiolone 7-phosphate 2-epimerase"
RHEA:46932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate
RHEA:20496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
RHEA:20740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trans-epoxysuccinate hydrolase"
RHEA:20740	skos:altLabel	"trans-epoxysuccinate hydratase"
RHEA:20740	skos:prefLabel	"trans-epoxysuccinate hydrolase"
RHEA:20740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trans-2,3-epoxysuccinate = (2R,3S)-tartrate
REACT:R-HSA-8939201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR dimerizes (Homo sapiens)
RHEA:46925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxy-4-methylpentanoyl-CoA => 4-methylpent-2-enoyl-CoA + H2O
RHEA:12651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-rhamnono-1,4-lactone + NADH => L-rhamnofuranose + NAD(+)
REACT:R-HSA-888589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GABA at the synapse (Homo sapiens)
REACT:R-BTA-9624017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SHC1 binds integrin alpha5beta1:fibronectin (Bos taurus)
REACT:R-CFA-6786421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIA hydrolyses chitin (Canis familiaris)
RHEA:61664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + ATP = (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)
RHEA:37851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-deoxydaunorubicin + H(+) + NADPH + O2 = 13-dihydrodaunorubicin + H2O + NADP(+)
GO:0004636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(5-phosphoribosyl)-ATP diphosphohydrolase activity
GO:0004636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosyl-ATP pyrophosphatase activity
GO:0004636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosyl-ATP diphosphatase activity
GO:0004636	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoribosyladenosine triphosphate pyrophosphatase activity
REACT:R-BTA-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Bos taurus)
REACT:R-GGA-5675194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPK phosphorylates RAF1 (Gallus gallus)
REACT:R-CEL-2534240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPG2 (perlecan) degradation by MMP14, MMP15 (Caenorhabditis elegans)
REACT:R-DDI-6803890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimerizes (Dictyostelium discoideum)
RHEA:56212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP
RHEA:25100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + UTP => ATP + UDP
GO:0019209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinase activator activity
REACT:R-DRE-482788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S54,92,203-BRF1 binds 14-3-3 (Danio rerio)
REACT:R-BTA-143468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEOS oxidizes ethanol to acetaldehyde (Bos taurus)
RHEA:40137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoate + CoA + H(+) => (9Z)-tetradecenoyl-CoA + H2O
RHEA:41791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + holo-[ACP] <=> acetyl-[ACP] + CoA
REACT:R-SCE-1676149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-DRE-997326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Danio rerio)
RHEA:19023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-RNO-8848975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS1 (Rattus norvegicus)
RHEA:13270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-glucose
REACT:R-SSC-2484965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII binds Integrin alpha1beta1 (Sus scrofa)
REACT:R-RNO-9710101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP4, CASP5 cleave GSDMD (Rattus norvegicus)
REACT:R-RNO-5688294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT5 deacetylates Cytochrome C (Rattus norvegicus)
REACT:R-DRE-9695890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Danio rerio)
REACT:R-DRE-77312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Danio rerio)
GO:0004409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homoaconitate hydratase"
GO:0004409	skos:altLabel	"homoaconitase"
GO:0004409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homoaconitate hydratase activity
GO:0004409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]
GO:0004409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-homoaconitase activity
GO:0004409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LysF
GO:0004409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HACN activity
GO:0004409	skos:altLabel	"HACN"
GO:0004409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-homoisocitrate = cis-homoaconitate + H2O
GO:0004409	skos:prefLabel	"homoaconitate hydratase"
GO:0004409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homoaconitase activity
GO:0004409	skos:altLabel	"cis-homoaconitase"
GO:0004409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Lys4
GO:0004409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity
GO:0004409	skos:altLabel	"2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase"
REACT:R-HSA-2396370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds collagens II, III and V (Homo sapiens)
REACT:R-DRE-449073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-3 cleaves pro-interleukin-16 (Danio rerio)
REACT:R-HSA-438037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
REACT:R-MMU-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Mus musculus)
RHEA:38862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP
REACT:R-DRE-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Danio rerio)
REACT:R-RNO-374899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of noradrenaline  at the synapse (Rattus norvegicus)
RHEA:63807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-gulose <=> GDP-beta-L-galactose
REACT:R-MMU-177284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates PDE4B (Mus musculus)
REACT:R-SSC-1112727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serine phosphorylation of STATs (Sus scrofa)
RHEA:48489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol--[retinol-binding protein] + NAD(+) => all-trans-retinal--[retinol-binding protein] + H(+) + NADH
RHEA:52887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-phenylhydroxylamine + 2 NADP(+) <=> 2 H(+) + 2 NADPH + nitrobenzene
REACT:R-BTA-5682983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates WHSC1 (Bos taurus)
REACT:R-MMU-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Mus musculus)
REACT:R-PFA-9796387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Plasmodium falciparum)
RHEA:13759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-desulfoglucotropeolin + UDP => (Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose
REACT:R-RNO-432121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL binds to LRP8 (Rattus norvegicus)
GO:0047083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity
GO:0047083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity
GO:0047083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity
GO:0047083	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)
REACT:R-HSA-6785047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10 positively regulates extracellular inflammatory mediators (Homo sapiens)
GO:0106320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-limonene 1,2-monooxygenase NADPH activity
GO:0106320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)
RHEA:26507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenamide + H2O => (9Z)-octadecenoate + NH4(+)
REACT:R-HSA-9757257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)
REACT:R-CFA-9701485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds JAK3 (Canis familiaris)
RHEA:54097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-HSA-2327738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Homo sapiens)
REACT:R-PFA-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Plasmodium falciparum)
REACT:R-CFA-74993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Canis familiaris)
RHEA:50322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-8879123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)
REACT:R-CFA-9036307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPER:Heterotrimeric G-protein Gs binds ESTG (Canis familiaris)
REACT:R-CFA-1604763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of MMP7 (Canis familiaris)
REACT:R-DRE-5682084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Danio rerio)
RHEA:65875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,17beta-dihydroxyandrostan-3-one + A <=> 17beta-hydroxyandrostan-1,3-dione + AH2
REACT:R-SSC-9710106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE cleaves GSDMD (Sus scrofa)
REACT:R-XTR-3322427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin recruits CBP/p300 (Xenopus tropicalis)
RHEA:66439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pentan-3-one <=> H(+) + NADPH + pent-1-en-3-one
REACT:R-SSC-5357429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL autophosphorylates on Y772 and Y814 (Sus scrofa)
REACT:R-MMU-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Mus musculus)
RHEA:10025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
RHEA:68768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine
REACT:R-CFA-71324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)
REACT:R-BTA-2029273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to p-6Y-SYK (Bos taurus)
REACT:R-DRE-2160874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses (HA)50 (Danio rerio)
REACT:R-DRE-8875576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRK,CRKL recruits RAC1 GEF to activated MET (Danio rerio)
REACT:R-DME-6785648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEMO1 binds RHOA:GTP:DIAPH1 (Drosophila melanogaster)
RHEA:49495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O
REACT:R-SCE-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Saccharomyces cerevisiae)
REACT:R-BTA-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Bos taurus)
REACT:R-XTR-350651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of MASK (Xenopus tropicalis)
REACT:R-BTA-77301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Bos taurus)
REACT:R-HSA-2134532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
REACT:R-BTA-2730894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB1:RELA translocates from the cytosol to the nucleus (Bos taurus)
RHEA:70388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-3-oxosphinganine
GO:0106332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ds/ssDNA junction-specific dsDNA endonuclease activity
REACT:R-DRE-8855954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Danio rerio)
REACT:R-XTR-417927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y2 receptor binds ATP and UTP (Xenopus tropicalis)
REACT:R-HSA-4570467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO1 (Homo sapiens)
REACT:R-XTR-8981574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)
GO:0015464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine receptor activity
REACT:R-BTA-975919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose by beta 4-galactosyltransferases (Bos taurus)
REACT:R-XTR-8987105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)
REACT:R-BTA-2395764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atREs binds to nascent CM (Bos taurus)
REACT:R-HSA-192331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)
REACT:R-BTA-8851550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase8 hydrolyzes nucleoside diphosphates (Bos taurus)
GO:0034768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-beta-ocimene synthase activity
REACT:R-XTR-389862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of glyoxylate to oxalate (Xenopus tropicalis)
RHEA:62459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + L-glutamate <=> diphosphate + L-glutamyl-5'-AMP
REACT:R-DRE-72231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Cleavage and Polyadenylation Complex (Danio rerio)
REACT:R-MMU-445084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by SRC (Mus musculus)
REACT:R-MMU-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
REACT:R-DDI-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)
REACT:R-SSC-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Sus scrofa)
RHEA:64917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate
RHEA:39750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol(in) <=> cholesterol(out)
RHEA:56688	skos:prefLabel	"tyrosine isonitrile desaturase"
RHEA:56688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tyrosine isonitrile desaturase"
RHEA:56688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate
RHEA:18513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol + O2 = D-mannose + H2O2
REACT:R-RNO-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)
RHEA:10931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-5682607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Homo sapiens)
REACT:R-CFA-9635739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 dephosphorylates p-T,Y-MAPKs (Canis familiaris)
REACT:R-RNO-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Rattus norvegicus)
REACT:R-SSC-109291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Sus scrofa)
REACT:R-GGA-5684081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds CDK2 and RBBP8 (Gallus gallus)
REACT:R-XTR-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Xenopus tropicalis)
EC:1.17.98.-	skos:prefLabel	"With other, known, acceptors"
EC:1.17.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
REACT:R-DRE-430135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds ADAP (Danio rerio)
REACT:R-DRE-735702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Danio rerio)
REACT:R-HSA-9717205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)
REACT:R-MMU-156930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-binding activates eEF2 (Mus musculus)
REACT:R-DDI-5324632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Dictyostelium discoideum)
REACT:R-MMU-442368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
REACT:R-SPO-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Schizosaccharomyces pombe)
RHEA:59850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH
RHEA:65610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + docosanoyl-CoA
REACT:R-HSA-500366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN28 binds POU5F1 (OCT4) mRNA (Homo sapiens)
REACT:R-HSA-9011981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 is recruited to MYC and BCL2 genes (Homo sapiens)
REACT:R-HSA-4084505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins bind HSPG2 (Homo sapiens)
RHEA:52275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine <=> gramine + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-3465545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Bos taurus)
REACT:R-DME-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Drosophila melanogaster)
REACT:R-MMU-2046094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Mus musculus)
RHEA:46500	skos:prefLabel	"uridine-5'-phosphate dioxygenase"
RHEA:46500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"uridine-5'-phosphate dioxygenase"
RHEA:46500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + UMP = CO2 + phosphate + succinate + uridine-5'-aldehyde
REACT:R-MMU-9638097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Mus musculus)
RHEA:11726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite
GO:0004781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenylylsulfate pyrophosphorylase activity
GO:0004781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:sulfate adenylyltransferase activity
GO:0004781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine-5'-triphosphate sulfurylase activity
GO:0004781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate adenylyltransferase (ATP) activity
GO:0004781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP sulfurylase activity
GO:0004781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfurylase activity
GO:0004781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-sulfurylase activity
GO:0004781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosinetriphosphate sulfurylase activity
GO:0004781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphate adenylyltransferase (ATP) activity
GO:0004781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfate adenylate transferase activity
RHEA:53729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-muramate 6-phosphate => N-acetyl-D-muramate + phosphate
REACT:R-BTA-8953946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Bos taurus)
GO:0043820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propionyl-CoA dehydrogenase activity
RHEA:55105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoheptanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyheptanoyl-[ACP] + NADP(+)
RHEA:19301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine + S-adenosyl-L-methionine = H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine
RHEA:19301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histamine N-methyltransferase"
RHEA:19301	skos:prefLabel	"histamine N-methyltransferase"
RHEA:18285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acyl-D-aspartate deacylase"
RHEA:18285	skos:prefLabel	"N-acyl-D-aspartate deacylase"
RHEA:18285	skos:altLabel	"N-acyl-D-aspartate amidohydrolase"
RHEA:18285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-aspartate + H2O = a carboxylate + D-aspartate
REACT:R-DRE-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Danio rerio)
GO:0030274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIM domain binding
REACT:R-BTA-9794008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LUBAC binds CFLAR (Bos taurus)
REACT:R-BTA-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)
RHEA:72320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n chloride(in) + urate(out) => n chloride(out) + urate(in)
REACT:R-HSA-200858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nef Binds and activates the Src-family tyrosine kinase Hck (Homo sapiens)
RHEA:13184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + nitrate(out) <=> ADP + H(+) + nitrate(in) + phosphate
RHEA:67980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-zeacarotene = 7,8-dihydro-beta-carotene
RHEA:40355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DME-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Drosophila melanogaster)
RHEA:62250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloroacetate + 2 H(+) + NADPH => chloroacetaldehyde + H2O + NADP(+)
REACT:R-HSA-5692788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JUN positively regulates MAPK6 gene expression (Homo sapiens)
REACT:R-SSC-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Sus scrofa)
REACT:R-CFA-8853793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-5Y-RET complexes bind GRB2 (Canis familiaris)
REACT:R-RNO-8950741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B:IL23A translocates from ER lumen to extracellular space (Rattus norvegicus)
RHEA:21628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + NADPH + O2 = acetate + androst-4-ene-3,17-dione + H2O + NADP(+)
REACT:R-CEL-5674496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate MAP2K1 (Caenorhabditis elegans)
REACT:R-SSC-5665998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 binds SRF (Sus scrofa)
RHEA:52017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate
REACT:R-BTA-8982641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Bos taurus)
RHEA:19684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + biotin + CoA <=> AMP + biotinyl-CoA + diphosphate
RHEA:45023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine
REACT:R-SSC-111285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)
RHEA:53474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol
RHEA:71576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphomethyl-dUMP in DNA + putrescine => 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate
RHEA:38282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalate + succinyl-CoA <=> (3R)-citramalyl-CoA + succinate
RHEA:24529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactaldehyde + NAD(+) => H(+) + methylglyoxal + NADH
RHEA:43813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine
REACT:R-DME-432487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CWO binds to cwo gene and represses transcription (Drosophila melanogaster)
REACT:R-CFA-2730843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LAT by p-SYK (Canis familiaris)
REACT:R-DRE-8951498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Danio rerio)
REACT:R-DME-204169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDP dephosphorylates p-lipo-PDH (Drosophila melanogaster)
RHEA:63300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine
REACT:R-XTR-6807053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SC5D desaturates LTHSOL to 7-dehydroCHOL (Xenopus tropicalis)
REACT:R-HSA-8939088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR1 gene expression is stimulated by RUNX1 (Homo sapiens)
REACT:R-MMU-183052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds to GRB2 (Mus musculus)
REACT:R-HSA-73912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Homo sapiens)
GO:0070774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytoceramidase activity
RHEA:35536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-phenylalanyl-L-leucyl) + O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2
RHEA:19037	skos:altLabel	"arene-oxide hydratase"
RHEA:19037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"soluble epoxide hydrolase"
RHEA:19037	skos:altLabel	"aryl epoxide hydrase"
RHEA:19037	skos:prefLabel	"soluble epoxide hydrolase"
RHEA:19037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an epoxide + H2O = an ethanediol
RHEA:19037	skos:altLabel	"trans-stilbene oxide hydrolase"
RHEA:19037	skos:altLabel	"epoxide hydratase"
RHEA:19037	skos:altLabel	"epoxide hydrase"
RHEA:19037	skos:altLabel	"cytosolic epoxide hydrolase"
REACT:R-DRE-199219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Danio rerio)
RHEA:24121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + leukotriene E4 + NADPH + O2 => 20-hydroxy-leukotriene E4 + H2O + NADP(+)
REACT:R-DME-9757688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDN (Drosophila melanogaster)
REACT:R-SSC-8944255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VII (Sus scrofa)
RHEA:70118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0102427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocryptopine 6-hydroxylase activity
REACT:R-CFA-190782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of connexon-containing transport vesicles from the Golgi (Canis familiaris)
RHEA:35438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose <=> cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP
RHEA:12166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + an aryl sulfate + H(+) => 3'-phosphoadenylyl sulfate + a phenol
RHEA:32776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate(out) + ATP + H2O => (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate
RHEA:69689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + genistein => genistein 7-O-beta-D-glucoside + H2O
RHEA:48570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4Z)-2-chloromuconate + 2 H(+) => 3-chlorocatechol + O2
RHEA:60894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O
REACT:R-HSA-6802933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
RHEA:37091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA
RHEA:69849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in RNA + H(+) + NADPH => a 5,6-dihydrouridine in RNA + NADP(+)
REACT:R-RNO-5675206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEA15 binds MAPK monomers and dimers (Rattus norvegicus)
REACT:R-HSA-163773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
RHEA:60108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-(4-hydroxyphenyl)lactoyl-CoA = (E)-4-coumaroyl-CoA + H2O
REACT:R-PFA-936883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Plasmodium falciparum)
REACT:R-BTA-9749583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Bos taurus)
RHEA:51187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphoserine + H2O <=> H(+) + octadecanoate + sn-glycero-3-phospho-L-serine
RHEA:40890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + octadecanoate + sn-glycerol 3-phosphocholine
REACT:R-MMU-390909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH2 binds hist (Mus musculus)
GO:0019705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-cysteine S-myristoyltransferase activity
GO:0019705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein]
REACT:R-MMU-349603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Mus musculus)
GO:0046979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAP2 binding
REACT:R-GGA-629599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Gallus gallus)
REACT:R-DME-193766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
REACT:R-HSA-9018497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive TFF3 gene expression (Homo sapiens)
RHEA:57913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) => H(+) + L-glutaminyl-tRNA(Gln) + phosphate
RHEA:22340	skos:altLabel	"m-hydroxybenzyl alcohol dehydrogenase"
RHEA:22340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybenzyl-alcohol dehydrogenase"
RHEA:22340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH
RHEA:22340	skos:prefLabel	"3-hydroxybenzyl-alcohol dehydrogenase"
RHEA:65596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-977615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates MCP/CR1-bound C4b/C3b (Mus musculus)
REACT:R-DDI-76031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 => O2 + 2 H2O (Dictyostelium discoideum)
RHEA:27906	skos:altLabel	"unsaturated acyl coenzyme A reductase"
RHEA:27906	skos:altLabel	"short-chain acyl-coenzyme A dehydrogenase"
RHEA:27906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"crotonyl-CoA reductase"
RHEA:27906	skos:altLabel	"ethylene reductase"
RHEA:27906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + NADP(+) = (2E)-butenoyl-CoA + H(+) + NADPH
RHEA:27906	skos:altLabel	"3-hydroxyacyl CoA reductase"
RHEA:27906	skos:prefLabel	"crotonyl-CoA reductase"
RHEA:27906	skos:altLabel	"enoyl-coenzyme A reductase"
RHEA:27906	skos:altLabel	"butyryl-CoA dehydrogenase"
GO:0045330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartyl esterase activity
REACT:R-DRE-5250209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP binds SLC25A4 (Danio rerio)
RHEA:66309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphoceramide + GDP-alpha-D-mannose => an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)
RHEA:48369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
RHEA:56203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP
RHEA:39365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA
RHEA:25268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + H2O + O2 <=> 2-phenylacetaldehyde + H2O2 + NH4(+)
RHEA:19027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + NH4(+) + oxaloacetate => H2O + L-aspartate + O2
REACT:R-SSC-216723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Sus scrofa)
REACT:R-RNO-158941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Rattus norvegicus)
RHEA:55093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + UDP-alpha-D-glucose => H(+) + sucrose + UDP
REACT:R-HSA-1604368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of bound proMMP2 (Homo sapiens)
RHEA:66452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) = 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH
REACT:R-RNO-1606789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARSB hydrolyses DS (Rattus norvegicus)
GO:0102083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydromonapterin aldolase activity
REACT:R-DRE-2018682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Danio rerio)
RHEA:71681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-lysyl-glycine(in) => H(+)(out) + L-lysyl-glycine(out)
REACT:R-DRE-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Danio rerio)
RHEA:64640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose = lactose + N-acetylneuraminate
RHEA:71925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + taurochenodeoxycholate(in) => 2 Na(+)(out) + taurochenodeoxycholate(out)
RHEA:30625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-lycopene => A + all-trans-neurosporene
RHEA:54721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:63457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + CTP => (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)
REACT:R-RNO-2243926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of histidino-hydroxylysinonorleucine cross-links (Rattus norvegicus)
REACT:R-RNO-3239014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)
RHEA:60336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:69387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) <=> (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]
REACT:R-DDI-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)
REACT:R-MMU-873927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of STAT1 dimer from active receptor unit (Mus musculus)
REACT:R-MMU-8937022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Mus musculus)
RHEA:33424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) => diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]
REACT:R-DRE-8848776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates DOK1 (Danio rerio)
RHEA:48862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => 18-HEPE + O2
RHEA:11539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + H2O + 2 O2 <=> glycine betaine + H(+) + 2 H2O2
REACT:R-DRE-211924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4B1 12-hydroxylates ARA (Danio rerio)
REACT:R-DDI-156699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Wee1 kinase (Dictyostelium discoideum)
REACT:R-CFA-8858428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FCAMR binds IgA (Canis familiaris)
REACT:R-HSA-8874849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBRF binds CREB3 (Homo sapiens)
REACT:R-HSA-9027043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)
REACT:R-MMU-9033527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Mus musculus)
REACT:R-GGA-8875816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 binds activated MET receptor (Gallus gallus)
GO:0019807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoacylase II activity
GO:0019807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylaspartate amidohydrolase activity
GO:0019807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-aspartic deaminase activity
GO:0019807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-L-aspartate amidohydrolase activity
GO:0019807	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylase II
GO:0019807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartoacylase activity
REACT:R-SSC-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Sus scrofa)
REACT:R-SSC-5627072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ binds GOPC:CFTR (Sus scrofa)
RHEA:19585	skos:prefLabel	"3alpha-hydroxycholanate dehydrogenase (NAD(+))"
RHEA:19585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + NAD(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADH
RHEA:19585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha-hydroxycholanate dehydrogenase (NAD(+))"
REACT:R-MMU-388832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds CD28 (Mus musculus)
REACT:R-XTR-1022129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)
RHEA:43855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + triacontanoyl-CoA <=> 3-oxo-dotriacontanoyl-CoA + CO2 + CoA
REACT:R-PFA-2993814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACA:Mn2+ (Plasmodium falciparum)
REACT:R-PFA-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Plasmodium falciparum)
REACT:R-CFA-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Canis familiaris)
RHEA:14472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminomuconate 6-semialdehyde + H2O + NAD(+) <=> (2Z,4E)-2-aminomuconate + 2 H(+) + NADH
REACT:R-BTA-9629492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves spiroiminodihydantoin (Bos taurus)
REACT:R-CFA-8847579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)
RHEA:10833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O => 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)
REACT:R-XTR-8865774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLLs polyglutamylate tubulin (Xenopus tropicalis)
RHEA:28974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + shikimate(in) <=> H(+)(out) + shikimate(out)
REACT:R-BTA-212614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamine transport from astrocytes (Bos taurus)
REACT:R-MMU-390250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Mus musculus)
REACT:R-BTA-114307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of SMAC (DIABLO) from mitochondria (Bos taurus)
REACT:R-SSC-68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Sus scrofa)
REACT:R-MMU-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Mus musculus)
RHEA:68730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-5668605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2:GTP binds NOX2 complex (Bos taurus)
RHEA:61356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + methotrexate(in) = ADP + H(+) + methotrexate(out) + phosphate
REACT:R-BTA-174392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)
REACT:R-DRE-451757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of nephrin and KIRREL2, KIRREL3 (Danio rerio)
GO:0018652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toluene-sulfonate methyl-monooxygenase activity
GO:0018652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	toluene-sulphonate methyl-monooxygenase activity
REACT:R-SSC-201685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin is released from the destruction complex (Sus scrofa)
RHEA:38240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA
REACT:R-HSA-5627071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Homo sapiens)
RHEA:42542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pseudouridine(13) in tRNA => uridine(13) in tRNA
REACT:R-DDI-5690080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP3,SAGA deubiquitinate Histone H2A,H2B (Dictyostelium discoideum)
RHEA:58203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 6-aminohexanoate <=> 6-oxohexanoate + L-glutamate
REACT:R-HSA-1855181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Homo sapiens)
REACT:R-HSA-212651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L-Glutamine (cytosol) to mitochondrial matrix (Homo sapiens)
RHEA:40028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9alpha-copalyl diphosphate + H2O => (13S)-vitexifolin A + diphosphate
REACT:R-HSA-9032323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxo-DPAn-3s translocate from cytosol to extracellular region (Homo sapiens)
RHEA:40445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+) => 6-deoxy-6-sulfo-D-fructose + ATP
REACT:R-CEL-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Caenorhabditis elegans)
RHEA:47867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-trioctanoylglycerol + H2O <=> dioctanoylglycerol + H(+) + octanoate
GO:0010348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithium:proton antiporter activity
GO:0010348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithium:hydrogen antiporter activity
RHEA:20664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanyl-D-alanine + H2O <=> 2 D-alanine
REACT:R-RNO-203712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS associates with Caveolin-1 (Rattus norvegicus)
REACT:R-CFA-8964241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)
RHEA:61295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + NAD(+) <=> 2-dehydropantoate + H(+) + NADH
REACT:R-SPO-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Schizosaccharomyces pombe)
REACT:R-DDI-9757256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM3 binds MCM5 (Dictyostelium discoideum)
REACT:R-CFA-450325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-FOS activation by phospho ERK1/2 (Canis familiaris)
REACT:R-BTA-8849881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM2 associate with AMPA and NMDA receptors (Bos taurus)
GO:0030151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mo ion binding
GO:0030151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdenum ion binding
GO:0030151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molybdenum binding
RHEA:71739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)
REACT:R-RNO-202717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of CEACAMs (Rattus norvegicus)
REACT:R-GGA-8938356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RMB14 binds RUNX2 (Gallus gallus)
REACT:R-HSA-4793819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer binds HSE on the target gene (Homo sapiens)
REACT:R-GGA-8938108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINB13 binds cathepsin L (Gallus gallus)
REACT:R-SPO-429101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMIT co-transports myo-inositol with a proton (Schizosaccharomyces pombe)
RHEA:37639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:19716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
REACT:R-SSC-159358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A3,4 dimers sulfate DA to DAOS (Sus scrofa)
REACT:R-MMU-202713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD84 homodimerises (Mus musculus)
RHEA:18119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-dopaquinone => L-tyrosine + O2
RHEA:58019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-6788912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)
REACT:R-BTA-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Bos taurus)
REACT:R-MMU-9014296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GEFs activate RAC2 (Mus musculus)
RHEA:11052	skos:altLabel	"4-aminobenzoate dehydrogenase"
RHEA:11052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-aminobenzoate 1-monooxygenase"
RHEA:11052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 2 H(+) + NADPH + O2 = 4-aminophenol + CO2 + H2O + NADP(+)
RHEA:11052	skos:altLabel	"4-aminobenzoate hydroxylase"
RHEA:11052	skos:prefLabel	"4-aminobenzoate 1-monooxygenase"
RHEA:11052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 2 H(+) + NADH + O2 = 4-aminophenol + CO2 + H2O + NAD(+)
RHEA:60082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+) => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2
RHEA:15943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-ornithine => H2O + N(2)-acetyl-L-ornithine
RHEA:33841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+)
REACT:R-HSA-427404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)
REACT:R-MMU-3322431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds TLE (Mus musculus)
REACT:R-DRE-9710254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME oligomerizes (Danio rerio)
RHEA:31332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + molybdopterin => adenylyl-molybdopterin + diphosphate
REACT:R-MMU-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Mus musculus)
GO:0061595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfofructose-1-phosphate aldolase activity
REACT:R-CFA-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Canis familiaris)
RHEA:15252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-galloyl-beta-D-glucose + UDP
GO:0042289	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	major histocompatibility complex class II ligand
GO:0042289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II protein binding
GO:0042289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	major histocompatibility complex class II binding
REACT:R-XTR-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Xenopus tropicalis)
REACT:R-DRE-6782628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates STAM2:HGS (Danio rerio)
RHEA:29156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) => 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)
REACT:R-RNO-392054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Rattus norvegicus)
RHEA:61867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dehydroprobetaenone I <=> A + probetaenone I
RHEA:38439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
RHEA:54511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-heptaprenyl diphosphate <=> beta-heptaprene + diphosphate
REACT:R-DRE-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Danio rerio)
GO:0046936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)
GO:0046936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadenosine deaminase reaction
GO:0046936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine deaminase activity
RHEA:19780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + L-pipecolate <=> AH2 + H(+) + L-1-piperideine-6-carboxylate
REACT:R-DRE-73739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Danio rerio)
REACT:R-XTR-8951428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Xenopus tropicalis)
GO:0001877	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lipoarabinomannan receptor activity
GO:0001877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAM receptor activity
GO:0001877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoarabinomannan immune receptor activity
GO:0080139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	borate efflux transmembrane transporter activity
GO:0080139	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	boron efflux transmembrane transporter activity
REACT:R-RNO-2065357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)
REACT:R-MMU-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Mus musculus)
REACT:R-HSA-1524186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by PDGFR (Homo sapiens)
REACT:R-MMU-193679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-secretase cleaves the p75NTR extracellular domain (Mus musculus)
RHEA:44100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate
RHEA:46102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisol + H2O + 2 oxidized [adrenodoxin] => 11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:56621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)
REACT:R-HSA-9694506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs (Homo sapiens)
REACT:R-DME-6810238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Drosophila melanogaster)
REACT:R-SSC-8848726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates BCAR1 (Sus scrofa)
REACT:R-MMU-9009541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds to TFF1 gene promoter (Mus musculus)
REACT:R-DRE-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Danio rerio)
REACT:R-SSC-8852280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds microtubule lattice in interphase cells (Sus scrofa)
REACT:R-BTA-166168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Bos taurus)
RHEA:52822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-succinyl-L-serine => L-serine + succinyl-CoA
RHEA:58259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] <=> ADP-D-ribose + L-seryl-[protein]
REACT:R-CEL-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Caenorhabditis elegans)
REACT:R-BTA-917835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from holoTF:TFRC dimer (Bos taurus)
RHEA:62774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-phenylalanine => N-acetyl-D-phenylalanine
REACT:R-BTA-8950733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Bos taurus)
RHEA:29337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + L-glutamate => H2O + L-alanyl-L-glutamate
REACT:R-HSA-9694467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spike protein forms a homotrimer (Homo sapiens)
REACT:R-SSC-3322431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds TLE (Sus scrofa)
REACT:R-CFA-909718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of p-STAT1 homodimer (Canis familiaris)
REACT:R-HSA-9696323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNRs bind CNR agonists (Homo sapiens)
REACT:R-XTR-8944242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVII (Xenopus tropicalis)
RHEA:38861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose
GO:0043782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin-3 C17-methyltransferase activity
GO:0043782	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cobalt-precorrin-3 methylase
GO:0043782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin-3B C17-methyltransferase activity
GO:0043782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cobalt-precorrin 3 C17-methyltransferase activity
GO:0043782	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cobalt-precorrin-3 methyltransferase
REACT:R-HSA-5624129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LZTFL1 binds the BBSome and prevents its traffic to the cilium (Homo sapiens)
REACT:R-SSC-2168887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Albumin to Hemopexin (Sus scrofa)
REACT:R-CEL-6807064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR24 reduces ZYMOL to ZYMSTNL (Caenorhabditis elegans)
REACT:R-DME-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Drosophila melanogaster)
RHEA:37167	skos:prefLabel	"farnesol dehydrogenase (NAD(+))"
RHEA:37167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"farnesol dehydrogenase (NAD(+))"
RHEA:37167	skos:altLabel	"NAD(+)-farnesol dehydrogenase"
RHEA:37167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + NAD(+) = (2E,6E)-farnesal + H(+) + NADH
RHEA:14254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine 3',5'-bis(diphosphate) + H2O => diphosphate + GDP + H(+)
GO:0034558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	technetium (VII) reductase activity
RHEA:60895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O <=> a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)
REACT:R-MMU-983422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of COPII coated vesicle (Mus musculus)
REACT:R-BTA-4551648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO1 (Bos taurus)
RHEA:61686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + phosphocholine => glycero-2-phosphocholine + H2O
REACT:R-MMU-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Mus musculus)
GO:0000213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-intron endonuclease activity
GO:0000213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA splicing endonuclease activity
GO:0000213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA-splicing endonuclease activity
GO:0000213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate intron endoribonuclease activity
GO:0000213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer splicing endonuclease activity
GO:0000213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNATRPintron endonuclease activity
GO:0000213	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	splicing endonuclease activity
GO:0000213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-intron endoribonuclease activity
REACT:R-CEL-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)
REACT:R-HSA-373074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR9  binds CCL25 ligand (Homo sapiens)
REACT:R-MMU-8862152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Mus musculus)
REACT:R-GGA-4551721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VHL with SUMO1 (Gallus gallus)
GO:0001054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase I activity
GO:0001054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter
RHEA:39846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA
EC:3.6.1.45	skos:altLabel	"nucleosidediphosphate-sugar pyrophosphatase"
EC:3.6.1.45	skos:altLabel	"UDP-sugar pyrophosphatase"
EC:3.6.1.45	skos:prefLabel	"UDP-sugar diphosphatase"
EC:3.6.1.45	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-sugar diphosphatase"
EC:3.6.1.45	skos:altLabel	"nucleosidediphosphate-sugar diphosphatase"
EC:3.6.1.45	skos:altLabel	"UDP-sugar hydrolase"
REACT:R-RNO-212004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Rattus norvegicus)
REACT:R-BTA-6788556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUBPL transfers 4Fe-4S to NDUFV1, V2 (Bos taurus)
REACT:R-BTA-376369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp2 associated secretory vesicle to plasma membrane transport (Bos taurus)
REACT:R-BTA-9038163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Bos taurus)
REACT:R-DRE-5263616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MeSeO2H is reduced to MeSeOH by TXNRD1 (Danio rerio)
RHEA:48857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O
RHEA:22767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
REACT:R-HSA-6802926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RHEA:58397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Bos taurus)
RHEA:64756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-benzyl-L-cysteine = benzylthiol + NH4(+) + pyruvate
RHEA:50097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:16081	skos:prefLabel	"methylphosphothioglycerate phosphatase"
RHEA:16081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylphosphothioglycerate phosphatase"
RHEA:16081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-S-methyl-3-phospho-1-thioglycerate + H2O = (2R)-S-methyl-1-thioglycerate + phosphate
RHEA:68664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)
REACT:R-BTA-9012542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Bos taurus)
REACT:R-RNO-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Rattus norvegicus)
REACT:R-MMU-6797803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRD binds SLITRK1-6 (Mus musculus)
REACT:R-DME-8869606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NAR to yield NAMN (Drosophila melanogaster)
REACT:R-DRE-2129353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin associates with microfibrils (Danio rerio)
REACT:R-RNO-9668389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Rattus norvegicus)
RHEA:45282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoate + phosphate => 12-(phosphooxy)octadecanoate + H2O
GO:0016689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mn(II):hydrogen-peroxide oxidoreductase activity
GO:0016689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peroxidase-M2
GO:0016689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mn-dependent peroxidase activity
GO:0016689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	manganese peroxidase activity
GO:0016689	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mn-dependent (NADH-oxidizing) peroxidase activity
REACT:R-HSA-400219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-TrCP1 binds phosphorylated PER proteins (Homo sapiens)
RHEA:25057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 <=> (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)
REACT:R-RNO-190245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1b binds to FGF (Rattus norvegicus)
RHEA:53825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADH
GO:0106050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA 2'-O-methyltransferase activity
RHEA:70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-aspartate(out) + L-glutamate(in) => H(+)(out) + L-aspartate(in) + L-glutamate(out)
REACT:R-MMU-198611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates IKKalpha (Mus musculus)
REACT:R-MMU-5218812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates PAK2 (Mus musculus)
REACT:R-CFA-504054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)
REACT:R-CEL-201717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK2-mediated phosphorylation of DVL (Caenorhabditis elegans)
REACT:R-HSA-983146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Homo sapiens)
REACT:R-DRE-73828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenylosuccinate => adenosine 5'-monophosphate + fumarate (Danio rerio)
GO:0061733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-lysine-N-acetylase activity
GO:0061733	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein acetyltransferase activity
GO:0061733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-lysine-N-acetylase activity
GO:0061733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-lysine-N-acetyltransferase activity
GO:0061733	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	protein acetylase activity
RHEA:52945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + UDP-alpha-D-glucuronate => choloyl-24-O-(beta-D-glucuronate) + UDP
RHEA:66966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose
REACT:R-XTR-8987084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Xenopus tropicalis)
REACT:R-DRE-8948709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Danio rerio)
RHEA:56111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-9661799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)
REACT:R-HSA-8863718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGFG1 binds VAMP7 (Homo sapiens)
REACT:R-HSA-6813740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDE1 hydrolyzes GroPIns (Homo sapiens)
REACT:R-SCE-965019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PDXP to PXLP (Saccharomyces cerevisiae)
REACT:R-XTR-451033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate <=> Fumarate + H2O (Xenopus tropicalis)
RHEA:27557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-hexaprenyl diphosphate + 2 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate
RHEA:38805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:70951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-serine + H2O + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)
REACT:R-SSC-5693575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-PKcs autophosphorylates (Sus scrofa)
REACT:R-BTA-9748996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers cleave AZA to 6MP (Bos taurus)
REACT:R-CEL-72631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the cap-binding eIF4F complex (Caenorhabditis elegans)
REACT:R-MMU-8855825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTRA1 hydrolyzes ACAN (Aggrecan) (Mus musculus)
RHEA:52080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + octadecanoate
RHEA:42498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetyl-2-debenzoylbaccatin III => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate
REACT:R-DRE-1362261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) associates with MuvB to form DREAM complex (Danio rerio)
REACT:R-DME-192137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
REACT:R-DRE-6798257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRS binds NTRK3 (Danio rerio)
RHEA:36359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2
RHEA:14508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + thiosulfate <=> glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite
RHEA:36377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl adenylate + diphosphate + phosphate => ATP + carbamoyl phosphate + H2O
REACT:R-HSA-9685189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 9b binds MAVS and PCBP2 (Homo sapiens)
RHEA:65228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol
RHEA:36740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptadecasphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine
RHEA:52946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-24-O-(beta-D-glucuronate) + UDP => cholate + UDP-alpha-D-glucuronate
REACT:R-HSA-163418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP (Homo sapiens)
EC:1.13.11.52	skos:altLabel	"tryptophan pyrrolase"
EC:1.13.11.52	skos:prefLabel	"indoleamine 2,3-dioxygenase"
EC:1.13.11.52	skos:altLabel	"IDO"
EC:1.13.11.52	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indoleamine 2,3-dioxygenase"
RHEA:62974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + 4 CoA + orsellinate => acetyl-CoA + 2 H(+) + 3 malonyl-CoA
GO:0016404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-specific 15-hydroxyprostaglandin dehydrogenase activity
GO:0016404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity
GO:0016404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	15-OH-PGDH
GO:0016404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	15-hydroxyprostaglandin dehydrogenase activity
GO:0016404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)
GO:0016404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0016404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	15-hydroxyprostanoic dehydrogenase activity
GO:0016404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity
GO:0016404	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prostaglandin dehydrogenase activity
REACT:R-BTA-6807206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)
RHEA:33064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] => NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]
REACT:R-DME-5672969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF (Drosophila melanogaster)
REACT:R-SSC-8951676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TEADs and YAP1 (Sus scrofa)
REACT:R-DRE-3234094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TFAP2C with SUMO1 (Danio rerio)
RHEA:17382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate => (9Z,11E)-octadecadienoate
REACT:R-CEL-170131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Caenorhabditis elegans)
RHEA:57780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chloro-4-nitrotoluene + NADH + O2 = 3-chloro-4-methylcatechol + NAD(+) + nitrite
REACT:R-SSC-6809263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Sus scrofa)
RHEA:42927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-870449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 monoubiquitinates SMAD4 (Bos taurus)
REACT:R-HSA-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Homo sapiens)
REACT:R-RNO-202245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of TBSMs in LAT (Rattus norvegicus)
REACT:R-DRE-5358599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Danio rerio)
RHEA:65668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine
RHEA:51855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)
RHEA:46961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:70769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine
RHEA:51389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dopamine => CoA + H(+) + N-acetyl-dopamine
REACT:R-HSA-265443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1-mediated cholesterol uptake (Homo sapiens)
REACT:R-RNO-1168373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Rattus norvegicus)
RHEA:71866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurodeoxycholate(out) <=> taurodeoxycholate(in)
GO:0102924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity
RHEA:22523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + H2O + O2 <=> all-trans-retinoate + H(+) + H2O2
REACT:R-MMU-6784598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPPA(124-151) binds NPR1 (Mus musculus)
RHEA:32001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bicyclogermacrene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-HSA-9011949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Homo sapiens)
REACT:R-RNO-1604359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP2 by MMP1, 7 (Rattus norvegicus)
RHEA:35937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AMP + brevianamide F + 2 diphosphate + 2 H(+) => 2 ATP + L-proline + L-tryptophan
REACT:R-MMU-158118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Mus musculus)
REACT:R-PFA-1467457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Plasmodium falciparum)
REACT:R-DRE-975449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABRR pentamers:GABA transports extracellular Cl- to cytosol (Danio rerio)
REACT:R-MMU-9638075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from DS (Mus musculus)
GO:0047031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diethyl 2-methyl-3-oxosuccinate reductase activity
GO:0047031	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity
REACT:R-CFA-5578777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DMPK phosphorylates PLN (Canis familiaris)
REACT:R-HSA-8984963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBI3 gene transcription and translation (Homo sapiens)
REACT:R-CFA-3323050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNRD2 catalyzes the reduction of TXN2 by NADPH (Canis familiaris)
REACT:R-XTR-5684006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translocates NBN to the nucleus (Xenopus tropicalis)
REACT:R-CFA-205136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC contributes to JNK activation (Canis familiaris)
REACT:R-SSC-2855054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ficolin-2 binds to molecular patterns on the target cell surface  (Sus scrofa)
REACT:R-XTR-1678921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length TLR3/7/8/9 binds to UNC93B1 (Xenopus tropicalis)
RHEA:46626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a L-5-monosubstituted hydantoin => a D-5-monosubstituted hydantoin
RHEA:40319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2
REACT:R-RNO-9018573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH3 binds activated EGFR (Rattus norvegicus)
REACT:R-DME-265783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Drosophila melanogaster)
RHEA:57233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GDP
RHEA:21334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetyl-D-glucosamine => acetyl-CoA + D-glucosamine
REACT:R-XTR-2022860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Xenopus tropicalis)
REACT:R-HSA-6803104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCD forms oligomeric complex (Homo sapiens)
REACT:R-MMU-933536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7 dimer interacts with coactivator CBP/p300 (Mus musculus)
REACT:R-MMU-390835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD1,5 bind DA (Mus musculus)
RHEA:43510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(dihydroxymethyl)-5-formylfuran => 2,5-diformylfuran + H2O
REACT:R-GGA-8938951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PAX5 (BSAP) (Gallus gallus)
RHEA:58125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde
RHEA:44788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-11 + S-adenosyl-L-methionine = H(+) + menaquinol-11 + S-adenosyl-L-homocysteine
RHEA:45965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O => 2 AMP + ATP + 2 H(+)
RHEA:38565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycerol + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O
REACT:R-GGA-110248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 3-methyladenine by MPG glycosylase  (Gallus gallus)
REACT:R-CFA-5672954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Canis familiaris)
RHEA:20110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,5-bisphosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate + ADP
GO:0019143	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity
GO:0019143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-manno-octulosonate-8-phosphatase activity
REACT:R-DDI-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)
RHEA:11614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)
RHEA:54051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> 4-epi-cubebol + diphosphate
REACT:R-PFA-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Plasmodium falciparum)
RHEA:64761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-ethyl-L-cysteine => ethanethiol + NH4(+) + pyruvate
REACT:R-MMU-114264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of activated BAX to the mitochondria (Mus musculus)
REACT:R-HSA-9021953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAMT gene expression is stimulated by MECP2 (Homo sapiens)
REACT:R-DRE-165182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of complexed TSC2 by PKB (Danio rerio)
REACT:R-RNO-199154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD200 binds to CD200R (Rattus norvegicus)
REACT:R-HSA-9013711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HES1 gene expression is stimulated by NOTCH4 (Homo sapiens)
GO:0019797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	procollagen-proline 3-dioxygenase activity
GO:0019797	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	prolyl 3-hydroxylase activity
GO:0019797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity
GO:0019797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protocollagen proline 3-hydroxylase activity
GO:0019797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	proline,2-oxoglutarate 3-dioxygenase activity
GO:0019797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	procollagen-proline,2-oxoglutarate 3-dioxygenase activity
GO:0019797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
RHEA:71527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine(out) = thymine(in)
REACT:R-HSA-5632674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRBK1 binds phosphorylated SMO dimer (Homo sapiens)
REACT:R-BTA-193789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Bos taurus)
RHEA:30095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + a menaquinone = a menaquinol + oxaloacetate
REACT:R-CFA-6805122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB binds TP53 (Canis familiaris)
RHEA:41311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate
GO:0005544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium-dependent phospholipid binding
REACT:R-XTR-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Xenopus tropicalis)
RHEA:61762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rebaudioside A + UDP => rebaudioside B + UDP-alpha-D-glucose
REACT:R-BTA-71118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)
REACT:R-HSA-9618584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPB and phospho-STAT3 bind the promoter of the MYC gene (Homo sapiens)
REACT:R-SSC-4084976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANS converts ManNAc-6-P to Neu5Ac-9-P (Sus scrofa)
REACT:R-HSA-9616367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 binds EGR1 to repress CDK5R1 gene expression (Homo sapiens)
GO:0030971	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transmembrane receptor protein tyrosine kinase ligand binding
GO:0030971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor tyrosine kinase binding
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypalmitoyl-ACP dehydratase activity
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxypalmitoyl thioester dehydratase activity
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxypalmityl-ACP dehydrase activity
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity
GO:0004317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
REACT:R-BTA-140870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Bos taurus)
RHEA:45015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octadecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + octadecanoate
RHEA:56139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a phenolic donor + H2O2 <=> 2 a phenolic radical donor + 2 H2O
RHEA:22538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine => (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine
REACT:R-SSC-8853734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Sus scrofa)
RHEA:11410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lumichrome + ribitol => H(+) + H2O + riboflavin
REACT:R-HSA-9032532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-bound FYN autophosphorylates (Homo sapiens)
REACT:R-BTA-8865667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPA hydrolyses sterol esters to sterols and fatty acids (Bos taurus)
REACT:R-BTA-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Bos taurus)
REACT:R-HSA-877158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 forms oligomeric non-selective cation channels (Homo sapiens)
REACT:R-MMU-174657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Mus musculus)
REACT:R-BTA-183094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds CBL:Beta-Pix (Bos taurus)
REACT:R-SSC-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Sus scrofa)
REACT:R-CFA-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Canis familiaris)
REACT:R-SCE-75891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive Initiation After Second Transition (Saccharomyces cerevisiae)
REACT:R-HSA-112152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Polymerase III Promoter Opening at Type 3 Promoters (Homo sapiens)
EC:3.11.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on carbon-phosphorus bonds"
EC:3.11.1.-	skos:prefLabel	"Acting on carbon-phosphorus bonds"
RHEA:49418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,5-bisphosphate + AMP + H(+) => ADP + alpha-D-ribose 1-phosphate
REACT:R-RNO-1234169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
RHEA:36142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hexadec-2-enoate + ATP + CoA <=> (2E)-hexadecenoyl-CoA + AMP + diphosphate
REACT:R-SCE-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Saccharomyces cerevisiae)
REACT:R-DRE-2537665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibulin-1 and -2 bind fibronectin (Danio rerio)
RHEA:11434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside
RHEA:67128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH = (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)
REACT:R-DRE-8869606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NAR to yield NAMN (Danio rerio)
REACT:R-BTA-110231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by MBD4 glycosylase (Bos taurus)
RHEA:72316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(in) + leukotriene C4(out) => glutathione(out) + leukotriene C4(in)
RHEA:68078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP => a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP
RHEA:20035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	penicillin N => isopenicillin N
REACT:R-XTR-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Xenopus tropicalis)
REACT:R-CEL-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Caenorhabditis elegans)
RHEA:37239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-UMP + H2O = H(+) + uridine 2'-phosphate
REACT:R-DRE-8987270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Danio rerio)
REACT:R-DRE-400677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rnd1 interacts with Plexin-B1:Sema4D (Danio rerio)
RHEA:55952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)
REACT:R-DRE-3928615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SFKs (Danio rerio)
REACT:R-SSC-177920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2 to GAB1 (Sus scrofa)
REACT:R-CFA-6814187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVL:PPL heterodimer binds the inner surface of the plasma membrane (Canis familiaris)
REACT:R-DDI-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Dictyostelium discoideum)
RHEA:69707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O = beta-D-galactose + N-hexadecanoylsphinganine
REACT:R-XTR-9660192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VDR agonists bind VDR (Xenopus tropicalis)
RHEA:38098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocotrienol + S-adenosyl-L-methionine <=> alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-6795473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates SGK1 (Gallus gallus)
RHEA:18168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl + H(+) + NADH + O2 <=> (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)
RHEA:72667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + secologanin = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin
RHEA:25156	skos:prefLabel	"phosphopantothenate--cysteine ligase (ATP)"
RHEA:25156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphopantothenate--cysteine ligase (ATP)"
RHEA:25156	skos:altLabel	"phosphopantothenoylcysteine synthetase"
RHEA:25156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + ATP + L-cysteine = AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
REACT:R-DRE-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Danio rerio)
REACT:R-DRE-8940641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THOP1 cleaves oligopeptide fragment (8-16aa) (Danio rerio)
RHEA:15593	skos:prefLabel	"amicoumacin phosphatase"
RHEA:15593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"amicoumacin phosphatase"
RHEA:15593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amicoumacin A 2-phosphate + H2O = amicoumacin A + phosphate
REACT:R-DME-8874745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Drosophila melanogaster)
RHEA:33965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + isopentenyl diphosphate => ATP + isopentenyl phosphate
REACT:R-MMU-2028670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Mus musculus)
RHEA:17077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine
RHEA:17077	skos:prefLabel	"dimethylglycine oxidase"
RHEA:17077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N-dimethylglycine + O2 = formaldehyde + H2O2 + sarcosine
RHEA:17077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dimethylglycine oxidase"
RHEA:15700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]
RHEA:54538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very long-chain fatty acyl-CoA + AMP + diphosphate => a very long-chain fatty acid + ATP + CoA
RHEA:20006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-glucuronoside + H2O => an alcohol + D-glucuronate
REACT:R-CFA-9034756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Canis familiaris)
REACT:R-XTR-8981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuroglobin:oxygen dissociates (Xenopus tropicalis)
RHEA:31150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylethyleneglycol + NAD(+) <=> 3,4-dihydroxymandelaldehyde + H(+) + NADH
RHEA:60202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2
REACT:R-MMU-158756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Mus musculus)
REACT:R-MMU-5686625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAIR1 binds collagen (Mus musculus)
REACT:R-BTA-912734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL:CRKL binds RAPGEF1 (Bos taurus)
REACT:R-SSC-3215406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds WDR77 (Sus scrofa)
GO:0070717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly-purine tract binding
REACT:R-GGA-199298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CREB1 (Gallus gallus)
REACT:R-XTR-2213208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type X collagen associates with collagen type II fibrils (Xenopus tropicalis)
REACT:R-GGA-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Gallus gallus)
REACT:R-RNO-3968414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Rattus norvegicus)
REACT:R-SPO-71691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)
RHEA:59458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + tetradecanal => NADP(+) + tetradecan-1-ol
RHEA:25263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + FADH2 => 2-hydroxyglutarate + FAD + H(+)
REACT:R-XTR-4719413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2,3,4 SUMOylate RORA with SUMO2 (Xenopus tropicalis)
EC:3.2.1.162	skos:altLabel	"endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase"
EC:3.2.1.162	skos:prefLabel	"lambda-carrageenase"
EC:3.2.1.162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lambda-carrageenase"
RHEA:42235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:13341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine
RHEA:13341	skos:prefLabel	"menaquinone C(8)-methyltransferase"
RHEA:13341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"menaquinone C(8)-methyltransferase"
RHEA:13341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine
REACT:R-HSA-5661219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds cadmium (Homo sapiens)
REACT:R-SSC-110352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of NTHL1 glycosylase by APEX1 at the AP site (Sus scrofa)
RHEA:67106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + novofumigatonin + succinate => 2-oxoglutarate + fumigatonoid C + O2
RHEA:14996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)
REACT:R-BTA-5694563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD10 hydrolyses MPAG (Bos taurus)
RHEA:49164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine
REACT:R-PFA-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Plasmodium falciparum)
RHEA:60306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine
RHEA:13279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate
REACT:R-GGA-937311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP12A:ATP4B exchanges K+ for H+ (Gallus gallus)
REACT:R-HSA-8939066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB gene expression is stimulated by RUNX1 (Homo sapiens)
GO:0090711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN hydrolase activity
REACT:R-XTR-5654734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Xenopus tropicalis)
RHEA:14000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-oxobutanoate + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + CO2 + NADH
GO:0047675	skos:prefLabel	"arabinonate dehydratase"
GO:0047675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arabinonate dehydratase"
GO:0047675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinonate hydro-lyase activity
GO:0047675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)
GO:0047675	skos:altLabel	"D-arabinonate hydro-lyase"
GO:0047675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arabinonate dehydratase activity
GO:0047675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O
RHEA:57237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GMP
RHEA:54596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + hexadecanoyl-CoA + O2 = 2-hydroxyhexadecanoyl-CoA + CO2 + succinate
RHEA:28105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-mannose + H2O <=> D-mannose + GDP + H(+)
REACT:R-SSC-8953946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Sus scrofa)
REACT:R-HSA-192325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(R) THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)
RHEA:41204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
RHEA:56395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)
RHEA:46738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacylglycerol + phosphate => H2O + monoacyl-sn-glycero-3-phosphate
REACT:R-SSC-9687638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds IP4, IP5 and IP6  (Sus scrofa)
RHEA:50495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]
GO:0030276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	clathrin binding
REACT:R-RNO-1250189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Rattus norvegicus)
REACT:R-BTA-9625487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates downstream of EGFR (Bos taurus)
REACT:R-BTA-5687101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 phosphorylates FOXO3 (Bos taurus)
RHEA:55327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + hexadecanoyl-CoA <=> 11-cis-retinyl hexadecanoate + CoA
RHEA:13400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + hexanedioate + NADPH
GO:1904067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ascr#2 binding
REACT:R-XTR-6798335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPGM dimer isomerises 1,3BPG to 2,3BPG (Xenopus tropicalis)
GO:0000049	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	base pairing with tRNA
GO:0000049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA binding
RHEA:22638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + diphosphate + H(+) => dCTP + H2O
REACT:R-RNO-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Rattus norvegicus)
RHEA:57464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + UDP-alpha-D-glucose = 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP
REACT:R-RNO-9733969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts dissociate from FABP6 (Rattus norvegicus)
REACT:R-RNO-71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer reduces PYR to LACT (Rattus norvegicus)
RHEA:72329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate
REACT:R-HSA-9636560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Eis acetylates DUSP16 (Homo sapiens)
REACT:R-CEL-9653503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B is phosphorylated on serine 181 (Caenorhabditis elegans)
REACT:R-PFA-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Plasmodium falciparum)
REACT:R-XTR-193497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Xenopus tropicalis)
REACT:R-DRE-5654515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAL1 binds HS (Danio rerio)
RHEA:66664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H(+) + phosphate
RHEA:57263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP <=> GDP + H(+) + lactate
REACT:R-DDI-3322995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Dictyostelium discoideum)
REACT:R-HSA-140872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Homo sapiens)
REACT:R-PFA-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Plasmodium falciparum)
REACT:R-XTR-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Xenopus tropicalis)
REACT:R-BTA-9727188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP4A:ATP4B binds PPIs (Bos taurus)
RHEA:32042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate <=> AMP + ATP + 2 H(+)
RHEA:64228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA
GO:0003985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiolase II
GO:0003985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-acetoacetyl coenzyme A thiolase activity
GO:0003985	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	2-methylacetoacetyl-CoA thiolase
GO:0003985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-oxothiolase activity
GO:0003985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetyl-CoA thiolase activity
GO:0003985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:N-acetyltransferase activity
GO:0003985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl coenzyme A thiolase activity
GO:0003985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA C-acetyltransferase activity
GO:0003985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA acetyltransferase activity
GO:0003985	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:acetyl-CoA C-acetyltransferase activity
RHEA:67441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(alpha)-acetyl-L-methionine => acetate + L-methionine
REACT:R-DME-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Drosophila melanogaster)
GO:0022818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium ion uniporter activity
RHEA:53807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholoyl-CoA + ursodeoxycholate <=> allodeoxycholate + ursodeoxycholoyl-CoA
REACT:R-CEL-3781941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNTs are secreted in exosomes (Caenorhabditis elegans)
REACT:R-RNO-8849085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RHOA:GTP (Rattus norvegicus)
RHEA:70630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
RHEA:59987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-acyl-L-glutamine + H2O <=> a carboxylate + L-glutamine
RHEA:36912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA
REACT:R-HSA-209868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
REACT:R-RNO-6801808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A,REG3G binds bacterial peptidoglycan (Rattus norvegicus)
REACT:R-PFA-5682285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA12 transports lipids from cytosol to extracellular region (Plasmodium falciparum)
REACT:R-GGA-168440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Gallus gallus)
GO:0036348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydantoin racemase activity
REACT:R-GGA-1433374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processing of SCF isoform 1 (Gallus gallus)
RHEA:51635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-5624952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the retrograde IFT train (Danio rerio)
REACT:R-RNO-6788623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STATs translocate to nucleus (Rattus norvegicus)
RHEA:40503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine = N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine
REACT:R-SSC-450406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S92,203-BRF1 binds 14-3-3 (Sus scrofa)
REACT:R-BTA-5654157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-PLCG1 dissociates from activated FGFR2 (Bos taurus)
RHEA:15399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride + formaldehyde + 2 H(+) => dichloromethane + H2O
RHEA:28862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ag(+)(in) + H(+)(in) <=> Ag(+)(out) + H(+)(out)
REACT:R-CFA-2029476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Role of myosins in phagosome formation (Canis familiaris)
RHEA:51654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + keto-D-tagaturonate + NADH => D-mannonate + NAD(+)
RHEA:34385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose
REACT:R-PFA-9754929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Plasmodium falciparum)
REACT:R-SSC-6801808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A,REG3G binds bacterial peptidoglycan (Sus scrofa)
REACT:R-DME-9718020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PTGFR agonists (Drosophila melanogaster)
RHEA:39577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH
RHEA:71377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + testosterone 17-sulfate(in) => 2 Na(+)(out) + testosterone 17-sulfate(out)
RHEA:35859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-MMU-5690702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYN phosphorylates CD22 (Mus musculus)
RHEA:15104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + meso-2,6-diaminoheptanedioate <=> CO2 + L-lysine
RHEA:35165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + minocycline(out) => H(+)(out) + minocycline(in)
REACT:R-CEL-72691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the 43S pre-initiation complex (Caenorhabditis elegans)
RHEA:47790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 28S rRNA + S-adenosyl-L-methionine
RHEA:52258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine
RHEA:61939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cycloheximide(in) + H2O <=> ADP + cycloheximide(out) + H(+) + phosphate
REACT:R-RNO-445084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by SRC (Rattus norvegicus)
RHEA:33726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)
EC:7.4.2.8	skos:prefLabel	"protein-secreting ATPase"
EC:7.4.2.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-secreting ATPase"
RHEA:32376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene-1,2-diol + NAD(+) => 1-hydroxylimonen-2-one + H(+) + NADH
REACT:R-BTA-2730902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of p-CARMA1 (Bos taurus)
REACT:R-CEL-2408551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SeMet is converted to AdoSeMet by MAT (Caenorhabditis elegans)
RHEA:31744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4'-hydroxyflavanone + S-adenosyl-L-methionine => a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine
EC:1.2.98.-	skos:prefLabel	"With other, known, acceptors"
EC:1.2.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
RHEA:45722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hexadecanoylsphing-4-enine(out) => N-hexadecanoylsphing-4-enine(in)
REACT:R-HSA-173115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pre-Integration Complex (PIC) (Homo sapiens)
REACT:R-SSC-913360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF receptor alpha subunit binds GM-CSF (Sus scrofa)
RHEA:33362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:70380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoyl-3-oxosphinganine
GO:0022804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	active transmembrane transporter activity
GO:0022804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	permease activity
GO:0022804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	active carrier activity
GO:0022804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pump activity
GO:0022804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carrier activity
REACT:R-RNO-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Rattus norvegicus)
RHEA:53780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-muricholate + lithocholoyl-CoA = beta-muricholoyl-CoA + lithocholate
REACT:R-GGA-421508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Synthesis of ALAS1 nascent polypeptide (Gallus gallus)
REACT:R-SPO-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)
REACT:R-RNO-9009072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 phosphorylation (Rattus norvegicus)
REACT:R-XTR-73945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAS-mediated dimerization of procaspase-8 (Xenopus tropicalis)
REACT:R-DDI-9641127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Dictyostelium discoideum)
RHEA:16295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-isopropylmalate => 2-isopropylmaleate + H2O
REACT:R-DRE-2484965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII binds Integrin alpha1beta1 (Danio rerio)
RHEA:63059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine
REACT:R-SSC-449077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-16 is secreted (Sus scrofa)
RHEA:31187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH
REACT:R-DRE-5205661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is recruited from the cytoplasm to the mitochondria (Danio rerio)
RHEA:45698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(acetyl)-sphing-4-enine-1-phosphate(out) => N-(acetyl)-sphing-4-enine-1-phosphate(in)
REACT:R-GGA-9008285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Gallus gallus)
REACT:R-HSA-9759751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAI1 binds the CLDN7 gene (Homo sapiens)
REACT:R-DME-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
REACT:R-CFA-163670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear transport of pChREBP (Thr 666) protein (Canis familiaris)
REACT:R-GGA-8981606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin binds oxygen (Gallus gallus)
REACT:R-SCE-5689539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)
GO:0015539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexuronate:cation symporter activity
GO:0015539	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hexuronate porter activity
GO:0015539	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	hexuronate (glucuronate/galacturonate) porter activity
REACT:R-XTR-5694126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C3B hydrolyses 7MGP to 7MG (Xenopus tropicalis)
RHEA:20040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol 6-phosphate + NADP(+) <=> aldehydo-D-glucose 6-phosphate + H(+) + NADPH
RHEA:13027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => 3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]
REACT:R-GGA-2395322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of lysyl-pyridinoline cross-links (Gallus gallus)
REACT:R-BTA-1483096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PETA is dephosphorylated to ETA by PHOSPHO1 (Bos taurus)
REACT:R-GGA-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Gallus gallus)
RHEA:28852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	melibiose(in) + Na(+)(in) => melibiose(out) + Na(+)(out)
REACT:R-DRE-70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine => putrescine + CO2 (Danio rerio)
GO:0102783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-carotene oxygenase activity
RHEA:12043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-(imidazol-5-yl)lactate + NADP(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADPH
REACT:R-SSC-3222116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L3MBTL1 binds TP53 monomethylated on K382 (Sus scrofa)
RHEA:23479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) <=> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
REACT:R-HSA-2161612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is reduced to PGF2a by FAM213B (Homo sapiens)
REACT:R-DRE-204861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shc1 (Danio rerio)
REACT:R-HSA-1980061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAG2 binds NOTCH2 (Homo sapiens)
REACT:R-CEL-5340226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB dioxygenates NO (Caenorhabditis elegans)
REACT:R-CEL-9684627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds CYSLTR1 antagonists (Caenorhabditis elegans)
REACT:R-CFA-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Canis familiaris)
RHEA:29198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + a menaquinone <=> a menaquinol + orotate
RHEA:70679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine(in) + H(+)(in) = glycine betaine(out) + H(+)(out)
RHEA:63042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + lovastatin carboxylate => H2O + lovastatin
REACT:R-CEL-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Caenorhabditis elegans)
GO:0008864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyl-FH(4) hydrolase activity
GO:0008864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyltetrahydrofolate hydrolase activity
GO:0008864	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	10-formyltetrahydrofolate amidohydrolase activity
GO:0008864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formyltetrahydrofolate deformylase activity
RHEA:50780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octanal = (2E)-octenal + H(+) + NADPH
REACT:R-HSA-5624127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)
REACT:R-HSA-4755600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective DOLK does not phosphorylate DCHOL (Homo sapiens)
REACT:R-GGA-4090281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Gallus gallus)
REACT:R-XTR-3296244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUCNR1 binds SUCCA (Xenopus tropicalis)
RHEA:28859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ag(+)(in) + H(+)(in) = Ag(+)(out) + H(+)(out)
RHEA:42072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z)-2-oxohept-4-enedioate + H2O = (4S)-4-hydroxy-2-oxoheptanedioate
RHEA:42072	skos:prefLabel	"2-oxo-hept-4-ene-1,7-dioate hydratase"
RHEA:42072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxo-hept-4-ene-1,7-dioate hydratase"
REACT:R-BTA-174144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)
REACT:R-SCE-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Saccharomyces cerevisiae)
REACT:R-CEL-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Caenorhabditis elegans)
REACT:R-CFA-9634850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNT (Canis familiaris)
GO:0043208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosphingolipid binding
REACT:R-RNO-5661115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Rattus norvegicus)
REACT:R-SSC-8873929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates STARD10 (Sus scrofa)
RHEA:41275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-eicosanoyl-sphing-4-enine = eicosanoate + sphing-4-enine
RHEA:20433	skos:prefLabel	"D-xylulose reductase"
RHEA:20433	skos:altLabel	"xylitol dehydrogenase"
RHEA:20433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-xylulose reductase"
RHEA:20433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + xylitol = D-xylulose + H(+) + NADH
REACT:R-CEL-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Caenorhabditis elegans)
RHEA:58680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + FADH2 = AH2 + FAD + H(+)
RHEA:63119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxynitrite <=> nitrate
EC:3.1.3.16	skos:altLabel	"protein phosphatase-2C"
EC:3.1.3.16	skos:altLabel	"protein phosphatase-2A"
EC:3.1.3.16	skos:altLabel	"protein phosphatase-2B"
EC:3.1.3.16	skos:prefLabel	"protein-serine/threonine phosphatase"
EC:3.1.3.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-serine/threonine phosphatase"
EC:3.1.3.16	skos:altLabel	"protein phosphatase-1"
EC:3.1.3.16	skos:altLabel	"serine/threonine specific protein phosphatase"
REACT:R-BTA-69005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc6 protein is phosphorylated by CDK (Bos taurus)
REACT:R-XTR-8932276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Xenopus tropicalis)
REACT:R-CFA-110355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MUTYH glycosylase by APEX1 at the AP site (Canis familiaris)
REACT:R-XTR-982778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone binds the growth hormone receptor (Xenopus tropicalis)
REACT:R-DDI-9687625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds MLKL (Dictyostelium discoideum)
REACT:R-RNO-444160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VMAT1/2 can mediate the transport of biogenic amines (Rattus norvegicus)
REACT:R-MMU-6810472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT13 hydrolyses AP6A to AP4 and ADP (Mus musculus)
RHEA:58800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cGAMP + H2O = 5'-pApG-3' + H(+)
GO:0030160	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GKAP/Homer scaffold activity
GO:0030160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	synaptic receptor adaptor activity
GO:0030160	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GKAP/Homer scaffold protein
GO:0030160	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	postsynaptic density scaffold protein
REACT:R-DME-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Drosophila melanogaster)
REACT:R-XTR-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Xenopus tropicalis)
RHEA:66858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate => (2E)-geranyl diphosphate + 3 isopentenyl diphosphate
RHEA:15715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-acetyl-beta-D-galactoside + CoA => a beta-D-galactoside + acetyl-CoA
REACT:R-DME-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)
REACT:R-MMU-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Mus musculus)
RHEA:29559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-alpha-D-glucuronate = 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP
RHEA:34688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + N-acyl-15-methylhexadecasphinganine + O2 => A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine
REACT:R-RNO-212263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 trimethylates histone H3 at lysine-27 (Rattus norvegicus)
RHEA:66093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + L-kynurenine => H2O + kynurenate + L-phenylalanine
RHEA:10865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 => 2-(acetamidomethylene)succinate + NADP(+)
GO:0030533	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA
GO:0030533	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer RNA
GO:0030533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triplet codon-amino acid adaptor activity
REACT:R-BTA-158925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Bos taurus)
RHEA:65584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) => Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O
REACT:R-MMU-349444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of COP1 at Ser-387  by ATM (Mus musculus)
RHEA:53871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + O2 + phenazine-1-carboxylate <=> 1-hydroxyphenazine + CO2 + H2O + NAD(+)
REACT:R-HSA-1168635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCB (PKC-beta) phosphorylates CARMA1 (Homo sapiens)
REACT:R-BTA-6814671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of late-endosome derived vesicles at the TGN (Bos taurus)
RHEA:17724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-RNO-8874685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds MET (Rattus norvegicus)
REACT:R-DME-5362437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-terminal Hh fragments are bound by lectins (Drosophila melanogaster)
RHEA:20976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary nitroalkane + H2O + O2 = an aldehyde + H(+) + H2O2 + nitrite
RHEA:52136	skos:prefLabel	"guaosine-5'-diphospho-5'-[DNA] diphosphatase"
RHEA:52136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)
RHEA:52136	skos:altLabel	"pp5'G5'-DNA guanylate hydrolase"
RHEA:52136	skos:altLabel	"pp5'G5'DNA diphosphatase"
RHEA:52136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guaosine-5'-diphospho-5'-[DNA] diphosphatase"
RHEA:52136	skos:altLabel	"aprataxin"
RHEA:17150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] => an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-9027281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Bos taurus)
REACT:R-CEL-170055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)
RHEA:10194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + sulfate(in) => ATP + H2O + sulfate(out)
RHEA:57225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + GTP => N(2)-(1-hydroxy-2-oxoethyl)-GTP
RHEA:68053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA + H2O => a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)
RHEA:59238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + isoelisabethatriene => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-HSA-2064418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1 (TAZ) binds ZO-2 (TJP2) (Homo sapiens)
REACT:R-BTA-8863101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPPL2a/b cleaves TNF(1-76) (Bos taurus)
RHEA:31584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-dATP + H2O => 2-oxo-dAMP + diphosphate + H(+)
REACT:R-MMU-9006844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21:IL21R:JAK1 binds IL2RG:JAK3 (Mus musculus)
RHEA:53509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate
REACT:R-GGA-532630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)
RHEA:40787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tetracosanoyl-CoA = CoA + H(+) + tetracosanoate
REACT:R-BTA-8848053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)
REACT:R-CFA-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Canis familiaris)
REACT:R-HSA-5661290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Homo sapiens)
RHEA:33614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl salicylate <=> H(+) + methanol + salicylate
REACT:R-BTA-110317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of correct bases opposite the lesion by POLH (Bos taurus)
REACT:R-DRE-451900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL2RB binds JAK1 (Danio rerio)
REACT:R-HSA-9018824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 binds effectors at the mitochondrial outer membrane (Homo sapiens)
GO:0070320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inward rectifier potassium channel inhibitor activity
RHEA:15732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH
REACT:R-SSC-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Sus scrofa)
REACT:R-GGA-8955010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRTOMT transfers Met to DA, forming 3MT (Gallus gallus)
GO:1905594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	resveratrol binding
RHEA:35503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9612672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:ESR1 binds ERBB4 gene promoter (Homo sapiens)
RHEA:31524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 2 H(+) + O2 => 3 CO2 + ethene + H2O
REACT:R-CFA-5665608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCF:Beta-catenin binds SOX proteins (Canis familiaris)
REACT:R-MMU-203613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylation of eNOS (Mus musculus)
GO:0047633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:agmatine 4-N-phosphotransferase activity
GO:0047633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:agmatine N4-phosphotransferase activity
GO:0047633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine kinase activity
GO:0047633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphagen phosphokinase activity
REACT:R-HSA-420688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABAB heterodimeric receptor binds GABA (Homo sapiens)
RHEA:67047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + asnovolin H <=> AH2 + chermesin D
REACT:R-BTA-3000335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Bos taurus)
RHEA:13974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+)(in) + H2O => 2 H(+)(out) + 2 phosphate
RHEA:72899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-demethylbarbatate + S-adenosyl-L-methionine = proatranorin I + S-adenosyl-L-homocysteine
REACT:R-DRE-3222072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAXX binds Ub-MDM2 and USP7 (Danio rerio)
REACT:R-SSC-5218805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC autophosphorylates (Sus scrofa)
REACT:R-DRE-422021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Danio rerio)
REACT:R-DME-190263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3b binds to FGF (Drosophila melanogaster)
RHEA:36648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine
REACT:R-MMU-977071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Mus musculus)
RHEA:67323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate <=> sch 210971
REACT:R-DRE-2168884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Methemoglobin to Hemopexin (Danio rerio)
REACT:R-HSA-2396007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3 is phosphorylated by TBK1 (Homo sapiens)
RHEA:35990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:57075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate 4-phosphate + H(+) <=> CO2 + L-erythrulose 1-phosphate
REACT:R-SCE-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Saccharomyces cerevisiae)
REACT:R-SSC-2453855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)
REACT:R-XTR-77329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Xenopus tropicalis)
RHEA:58622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanamide + glyoxylate => N-decanoyl-(2S)-hydroxyglycine
RHEA:65927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine
GO:0047406	skos:prefLabel	"beta-aspartyl-N-acetylglucosaminidase"
GO:0047406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-aspartyl-N-acetylglucosaminidase"
GO:0047406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity
GO:0047406	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-aspartylacetylglucosaminidase activity
GO:0047406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-aspartyl-N-acetylglucosaminidase activity
GO:0047406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = L-asparagine + N-acetyl-D-glucosamine
RHEA:66169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-with a C-terminal TM segment(out) + ATP + H2O => [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate
REACT:R-DRE-9013161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GAPs stimulate CDC42 GTPase activity (Danio rerio)
RHEA:66622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]
RHEA:17429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + trans-4-hydroxycyclohexanecarboxylate = 4-oxocyclohexanecarboxylate + H(+) + NADH
RHEA:17429	skos:prefLabel	"4-hydroxycyclohexanecarboxylate dehydrogenase"
RHEA:17429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxycyclohexanecarboxylate dehydrogenase"
RHEA:66609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O => GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)
RHEA:32837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate(out) => 4-(trimethylamino)butanoate(in)
REACT:R-HSA-9705465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT1,3,5 dimer binds SOCS3 gene (Homo sapiens)
RHEA:54384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))"
RHEA:54384	skos:altLabel	"3-oxo-5alpha-steroid 4-dehydrogenase"
RHEA:54384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH
RHEA:54384	skos:prefLabel	"3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))"
RHEA:54384	skos:altLabel	"cholestenone 5alpha-reductase"
REACT:R-DME-193064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3-like proteins reducde ANDST to TEST (Drosophila melanogaster)
GO:0052628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl amino acid synthetase activity
GO:0052628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxybenzoate amino acid synthetase activity
GO:0052628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate amino acid synthetase activity
GO:0052628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxybenzoyl amino acid synthetase activity
GO:0052628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4HBA amino acid synthetase activity
RHEA:20552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + 2 thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate
REACT:R-CFA-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Canis familiaris)
REACT:R-CFA-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Canis familiaris)
REACT:R-CFA-70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Canis familiaris)
REACT:R-PFA-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)
GO:0031813	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	P2Y2 nucleotide receptor ligand
GO:0031813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y2 nucleotide receptor binding
REACT:R-GGA-1168894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5A/B dissociates from the Growth Hormone receptor (Gallus gallus)
REACT:R-BTA-209840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two DITs combine to form thyroxine (Bos taurus)
REACT:R-HSA-9618834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated calmodulin dissociates from CaMKII-gamma (Homo sapiens)
RHEA:40155	skos:altLabel	"CYP4V2"
RHEA:40155	skos:altLabel	"CYP4F3B"
RHEA:40155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"docosahexaenoic acid omega-hydroxylase"
RHEA:40155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40155	skos:prefLabel	"docosahexaenoic acid omega-hydroxylase"
RHEA:14374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]
REACT:R-DRE-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Danio rerio)
RHEA:52233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin a
REACT:R-CFA-1112690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11 binds CBL (Canis familiaris)
RHEA:21740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate
RHEA:21740	skos:prefLabel	"3-mercaptopyruvate sulfurtransferase"
RHEA:21740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-mercaptopyruvate sulfurtransferase"
REACT:R-BTA-1483219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is exchanged with PI by PITPNB (Bos taurus)
RHEA:63438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) => 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O
REACT:R-DDI-5693346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CECRI deaminates Ade-Rib to Ino (Dictyostelium discoideum)
RHEA:53417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-amino-8-demethylriboflavin + S-adenosyl-L-methionine => 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine
REACT:R-DME-170986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ral-GDS binds to Ras-GTP (Drosophila melanogaster)
REACT:R-HSA-5692550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 (Homo sapiens)
RHEA:45850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydodecanoyl-CoA + NADP(+)
REACT:R-CEL-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Caenorhabditis elegans)
RHEA:61203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]
RHEA:46094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:29011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + H(+)(in) = 2-oxoglutarate(out) + H(+)(out)
REACT:R-BTA-3371359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Bos taurus)
REACT:R-GGA-199062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLRC1:KLRD1 heterodimer interacts with HLA-E (Gallus gallus)
RHEA:22332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-citramalate = 2-methylmaleate + H2O
RHEA:50797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione + prostaglandin A2 => prostaglandin A2-S-(R)-glutathione
REACT:R-BTA-8863494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASICs bind STOML3, (STOM) (Bos taurus)
REACT:R-RNO-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Rattus norvegicus)
REACT:R-DDI-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Dictyostelium discoideum)
REACT:R-MMU-3928591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN tetramers oligomerise (Mus musculus)
RHEA:53410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2
RHEA:48781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-erythrulose => ADP + H(+) + L-erythrulose 1-phosphate
RHEA:11912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + H(+) + NADPH
REACT:R-HSA-9682626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp13 binds nsp12 (Homo sapiens)
REACT:R-SPO-450533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCdelta phosphorylates HuR (Schizosaccharomyces pombe)
RHEA:54901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenoyl-[ACP] + H(+) + NADH => hexadecanoyl-[ACP] + NAD(+)
GO:0140905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	haloperoxidase activity
REACT:R-SPO-112430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of P-TEFb complex (Schizosaccharomyces pombe)
GO:0042957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dextrin transmembrane transporter activity
REACT:R-CFA-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Canis familiaris)
REACT:R-HSA-9636008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 resolves abasic site-induced ICLs (Homo sapiens)
REACT:R-MMU-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
REACT:R-CEL-8866405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)
REACT:R-XTR-4641362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP1 with SUMO1 (Xenopus tropicalis)
REACT:R-DDI-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)
RHEA:68559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine <=> H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
REACT:R-GGA-5621363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Gallus gallus)
REACT:R-MMU-2230938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin:Haptoglobin:CD163 is endocytosed (Mus musculus)
RHEA:67012	skos:altLabel	"GTP--RNA guanylyltransferase"
RHEA:67012	skos:altLabel	"mRNA capping enzyme"
RHEA:67012	skos:prefLabel	"mRNA guanylyltransferase"
RHEA:67012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate
RHEA:67012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mRNA guanylyltransferase"
RHEA:19609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine
RHEA:19609	skos:prefLabel	"16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase"
RHEA:19609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase"
REACT:R-HSA-434990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA7A binds to integrin alpha1beta1 (Homo sapiens)
REACT:R-XTR-73548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Xenopus tropicalis)
REACT:R-CFA-373717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacts with DIP13alpha (Canis familiaris)
RHEA:43215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:16786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in tRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-1981104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Canis familiaris)
REACT:R-XTR-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Xenopus tropicalis)
RHEA:69447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> alpha-cadinene + diphosphate
REACT:R-DDI-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Dictyostelium discoideum)
RHEA:67060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asnovolin I + S-adenosyl-L-methionine = asnovolin K + S-adenosyl-L-homocysteine
REACT:R-HSA-8950415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of heterogeneous nuclear ribonucleoprotein F (Homo sapiens)
REACT:R-HSA-9612257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAP1 gene expression is inhibited by ERBB4s80 (Homo sapiens)
REACT:R-DDI-70952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Dictyostelium discoideum)
REACT:R-GGA-6805205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR35 binds kynurenic acid (Gallus gallus)
REACT:R-SSC-209960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diiodinated tyrosine can be deiodinated (Sus scrofa)
REACT:R-DDI-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)
REACT:R-SSC-1678841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Sus scrofa)
REACT:R-RNO-3965444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT:FZD complex promotes G-protein nucleotide exchange (Rattus norvegicus)
REACT:R-XTR-2672334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCNN channels transport extracellular Na+ to cytosol (Xenopus tropicalis)
RHEA:20326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-4-acetylaminobiphenyl => N-acetoxy-4-aminobiphenyl
REACT:R-BTA-9657606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
RHEA:24542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + D-glucono-1,5-lactone => A + D-glucose
REACT:R-MMU-109858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 binds MAPK1 (Mus musculus)
REACT:R-HSA-8848774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds DOK1 (Homo sapiens)
GO:0047277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside alpha-N-acetylgalactosaminyltransferase activity
GO:0047277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Forssman synthase activity
GO:0047277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	globoside acetylgalactosaminyltransferase activity
GO:0047277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity
GO:0047277	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity
REACT:R-SSC-5694126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C3B hydrolyses 7MGP to 7MG (Sus scrofa)
RHEA:26373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2
REACT:R-MMU-428052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Mus musculus)
RHEA:67398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-4551616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of RPA1 (RPA70) with SUMO2,3 (Rattus norvegicus)
REACT:R-SSC-9024872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 oxidises 17(S)-Hp-DHA to PDX (Sus scrofa)
REACT:R-XTR-5624473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Xenopus tropicalis)
GO:0052683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-gamma-bisabolene synthase activity
GO:0052683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming] activity
RHEA:31385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lupeol => (S)-2,3-epoxysqualene
REACT:R-RNO-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Rattus norvegicus)
REACT:R-GGA-5607722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active NIK phosphorylates IKKA dimer (Gallus gallus)
RHEA:61100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-8964614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Gallus gallus)
RHEA:70306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine
REACT:R-DRE-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Danio rerio)
RHEA:64769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-3-(hexan-1-ol)-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol
RHEA:12764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	precorrin-3B + S-adenosyl-L-methionine <=> 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine
RHEA:69909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + uridine(in) => 2 Na(+)(out) + uridine(out)
RHEA:40623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tritetradecanoylglycerol = 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate
REACT:R-XTR-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Xenopus tropicalis)
RHEA:47240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]
GO:0004815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-tRNA ligase activity
GO:0004815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic acid translase activity
GO:0004815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartyl-transfer ribonucleic acid synthetase activity
GO:0004815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartyl-transfer RNA synthetase activity
GO:0004815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartyl-tRNA synthetase activity
GO:0004815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartyl ribonucleate synthetase activity
GO:0004815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate:tRNAAsp ligase (AMP-forming)
GO:0004815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartyl ribonucleic synthetase activity
RHEA:41785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) => CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)
RHEA:54818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+) => L-glutaminyl-[protein] + L-lysyl-[protein]
REACT:R-DRE-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Danio rerio)
RHEA:71283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-glutamine(out) + 2 Na(+)(out) = chloride(in) + L-glutamine(in) + 2 Na(+)(in)
GO:0052712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol phosphosphingolipid phospholipase activity
RHEA:18895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose
REACT:R-HSA-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
RHEA:54244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-GGA-981497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Gallus gallus)
REACT:R-BTA-8875817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates STAT3 (Bos taurus)
RHEA:72469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 CO2 + 8 CoA + H2O + o-orsellinate depside => 2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA
REACT:R-DRE-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Danio rerio)
REACT:R-XTR-606287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSF complex binds the centromere (Xenopus tropicalis)
REACT:R-HSA-9735840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 7a binds BST2 (Homo sapiens)
REACT:R-HSA-164512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Second strand transfer by annealing complementary PBS sequences (Homo sapiens)
REACT:R-RNO-5649701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Rattus norvegicus)
RHEA:18764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)
REACT:R-RNO-5661123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A, KDM1B demethylate Me2K5-histone H3 (Rattus norvegicus)
REACT:R-SPO-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Schizosaccharomyces pombe)
REACT:R-DME-176604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Drosophila melanogaster)
REACT:R-DME-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Drosophila melanogaster)
GO:0004824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine translase activity
GO:0004824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine-transfer RNA ligase activity
GO:0004824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysyl-tRNA synthetase activity
GO:0004824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysine-tRNA synthetase activity
GO:0004824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-lysine:tRNALys ligase (AMP-forming)
GO:0004824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine-tRNA ligase activity
GO:0004824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysyl-transfer RNA synthetase activity
GO:0004824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lysyl-transfer ribonucleate synthetase activity
REACT:R-SSC-382058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nck binds to the active PDGF receptor (Sus scrofa)
REACT:R-RNO-5682802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI3 binds ADAM22,23,synatxin1 (Rattus norvegicus)
REACT:R-CFA-205118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 polyubiquitinates NRIF (Canis familiaris)
RHEA:71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + thiocyanate(out) <=> 2 Na(+)(in) + thiocyanate(in)
REACT:R-CEL-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)
RHEA:41351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
GO:0106162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate
GO:0106162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA N-acetyltransferase activity
REACT:R-BTA-174967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT2 acetylation (Bos taurus)
REACT:R-RNO-2022405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)
REACT:R-BTA-9705507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3B hydrolyses cAMP to AMP (Bos taurus)
RHEA:47108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + taurine = H2O + taurocholate
REACT:R-MMU-6785361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Monoubiquitination of FANCD2:FANCI (Mus musculus)
RHEA:52155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-indolylmethyl desulfoglucosinolate + UDP
REACT:R-DRE-5696491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNTF binds CNTFR complex (Danio rerio)
RHEA:32678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + H2O <=> alpha-D-glucose + beta-D-glucose
RHEA:13762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionine
RHEA:66137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + tyramine => CoA + H(+) + N-acetyltyramine
REACT:R-SPO-70286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Schizosaccharomyces pombe)
REACT:R-SSC-909720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN alpha/beta binds to IFNAR2 (Sus scrofa)
REACT:R-XTR-6799777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind PPP1R13B or TP53BP2 (Xenopus tropicalis)
REACT:R-CFA-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Canis familiaris)
REACT:R-CFA-202718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Canis familiaris)
REACT:R-RNO-9706336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SYK (Rattus norvegicus)
REACT:R-DDI-1855162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Dictyostelium discoideum)
REACT:R-RNO-381496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the IGF:IGFBP3:ALS complex (Rattus norvegicus)
REACT:R-RNO-193995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B2 18-hydroxylates CORST to 18HCORST (Rattus norvegicus)
REACT:R-CEL-77589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition of AAUAAA sequence by CPSF (Caenorhabditis elegans)
RHEA:20447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + prephenate => L-arogenate + oxaloacetate
RHEA:17204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-arabinonate <=> 2,5-dioxopentanoate + H2O
RHEA:43453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA
REACT:R-DME-450173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 induces oligomerisation of TRAF6 (Drosophila melanogaster)
RHEA:30430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-germacrene D + diphosphate
REACT:R-SPO-2990840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO1 (Schizosaccharomyces pombe)
RHEA:55092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + UDP-alpha-D-glucose = H(+) + sucrose + UDP
RHEA:47896	skos:prefLabel	"sulfoquinovose 1-dehydrogenase"
RHEA:47896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfoquinovose 1-dehydrogenase"
RHEA:47896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-D-quinovose + NAD(+) = 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH
RHEA:64954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H(+) + phosphate => dCDP + H2O
GO:0008798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-aspartyl-peptidase activity
GO:0008798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-aspartyl peptidase activity
GO:0008798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770) (Homo sapiens)
GO:0008798	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-aspartyl dipeptidase activity
REACT:R-GGA-9681763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1 binds IL1R1 inhibitors (Gallus gallus)
REACT:R-HSA-192341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Homo sapiens)
REACT:R-HSA-2033486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding (Homo sapiens)
REACT:R-RNO-5618073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Rattus norvegicus)
REACT:R-HSA-391872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1 cis-homophilic interaction (Homo sapiens)
REACT:R-DDI-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Dictyostelium discoideum)
REACT:R-SSC-5578965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNRC6A binds AGO2:miRNA (Sus scrofa)
REACT:R-CFA-8853515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTULIN,USP5 cleaves UBC yielding ubiquitin (Canis familiaris)
REACT:R-SSC-211983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2J2 oxidises ARA (Sus scrofa)
RHEA:38242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA
REACT:R-MMU-5665809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Mus musculus)
REACT:R-HSA-373732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin trans-homophilic interaction (Homo sapiens)
REACT:R-DME-74181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Drosophila melanogaster)
REACT:R-GGA-373042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ (Gallus gallus)
REACT:R-SPO-109637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Schizosaccharomyces pombe)
REACT:R-SSC-6807224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-BGLAP to BGLAP (Sus scrofa)
REACT:R-DRE-5324617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:FKBP4:PTGES3 binds HSF1 trimer (Danio rerio)
REACT:R-SSC-1483002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to 1-acyl GO3P by GNPAT (Sus scrofa)
RHEA:28036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + ADP => [thioredoxin]-disulfide + dADP + H2O
RHEA:58706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin ortho-naphthoquinone carboxamide => rifampicin hemiaminal
RHEA:17183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu => a long-chain fatty aldehyde + FMNH2 + O2
RHEA:67376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyl-L-histidine + H2O = glycine + L-histidine
RHEA:29553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose
REACT:R-HSA-388811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-1 homodimer (Homo sapiens)
REACT:R-MMU-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Mus musculus)
RHEA:55810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O => a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-HSA-9634846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds ARNTL (BMAL1) (Homo sapiens)
REACT:R-HSA-9662773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAM17 binds Zn2+ (Homo sapiens)
RHEA:52225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 3 H(+) + heme b + 3 O2 => 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O
REACT:R-RNO-8848124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAT3 (Rattus norvegicus)
RHEA:64899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + UTP <=> 2 H(+) + 2 phosphate + UMP
RHEA:52891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-phenylhydroxylamine + NADP(+) <=> H(+) + NADPH + nitrosobenzene
REACT:R-DRE-6814124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binds G-protein beta associated TRiC/CCT (Danio rerio)
REACT:R-RNO-70920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Rattus norvegicus)
REACT:R-PFA-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Plasmodium falciparum)
REACT:R-XTR-1112510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6ST is tyrosine phosphorylated (Xenopus tropicalis)
RHEA:10246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetate + fumarate + H(+) => 4-fumarylacetoacetate + H2O
RHEA:36320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADPH + octadecanoyl-CoA => CoA + 2 NADP(+) + octadecan-1-ol
REACT:R-SSC-4332235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds TGFBR2 (Sus scrofa)
REACT:R-GGA-1227778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEKK1 binds TRAF6  (Gallus gallus)
RHEA:32079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13E)-labda-7,13-dien-15-yl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate
REACT:R-MMU-5696534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 deubiquitinates TAK1:TAB1 (Mus musculus)
RHEA:56269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
REACT:R-BTA-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Bos taurus)
RHEA:35547	skos:altLabel	"CYP121"
RHEA:35547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:35547	skos:prefLabel	"mycocyclosin synthase"
RHEA:35547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mycocyclosin synthase"
REACT:R-HSA-3797202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP-1 stimulates transcription of IGFBP7 (Homo sapiens)
REACT:R-CFA-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Canis familiaris)
REACT:R-GGA-74740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SHC1 to insulin receptor (Gallus gallus)
REACT:R-DRE-5631941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind AMPK (Danio rerio)
REACT:R-GGA-1227695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. (Gallus gallus)
RHEA:40046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + L-glutamate <=> ADP + beta-citrylglutamate + H(+) + phosphate
RHEA:32867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol(out) = myo-inositol(in)
REACT:R-SSC-167433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein beta-gamma subunits rebind the alpha-GDP subunit (Sus scrofa)
REACT:R-MTU-868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-glucan is converted to glucanotrehalose (Mycobacterium tuberculosis)
REACT:R-GGA-9021609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR-associated SRC autophosphorylates (Gallus gallus)
GO:0018516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorobenzoyl-CoA reductase activity
GO:0018516	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)
RHEA:36473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4,5-trihydroxybenzoate(in) + H(+)(in) => 3,4,5-trihydroxybenzoate(out) + H(+)(out)
REACT:R-SSC-9750226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 binds IKBKB and CHUK (Sus scrofa)
REACT:R-HSA-8944632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-106 microRNAs bind PTEN mRNA (Homo sapiens)
REACT:R-MMU-5638004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RP2 binds ARL3:GTP:UNC119B (Mus musculus)
REACT:R-RNO-6811427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPI vesicle uncoating at the ER (Rattus norvegicus)
GO:0008448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylglucosamine phosphate deacetylase activity
GO:0008448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity
GO:0008448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Homo sapiens)
GO:0008448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosamine-6-phosphate deacetylase activity
GO:0008448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylaminodeoxyglucosephosphate acetylhydrolase activity
GO:0008448	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity
GO:0010280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-L-rhamnose synthase activity
GO:0010280	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity
REACT:R-CEL-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Caenorhabditis elegans)
REACT:R-GGA-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)
REACT:R-HSA-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Homo sapiens)
REACT:R-CEL-5681987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 is cleaved by ATG4 (Caenorhabditis elegans)
GO:0003714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcription co-repressor activity
GO:0003714	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II transcription corepressor activity
GO:0003714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription corepressor activity
GO:0003714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transcription co-repressor activity
REACT:R-RNO-8875451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates CBL (Rattus norvegicus)
REACT:R-CFA-432237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Canis familiaris)
REACT:R-HSA-5690565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)
RHEA:59817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + a sterol => a sterol ester + CoA
RHEA:70493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+) => GDP-beta-L-fucose + L-threonyl-[protein]
REACT:R-BTA-6800200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPN heterodimer cleaves pro-HGF to form HGF dimer (Bos taurus)
RHEA:17099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	enol-phenylpyruvate => 3-phenylpyruvate
RHEA:13611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP
REACT:R-HSA-9709273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA2 translocates to the nucleus (Homo sapiens)
REACT:R-BTA-2454208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta and gamma subunits by LYN (Bos taurus)
RHEA:36907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA = (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA
RHEA:54582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+) => a 5'-end dephospho-ribonucleoside-RNA + ATP
REACT:R-HSA-8949580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F1Fo ATP synthase dimerizes (Homo sapiens)
GO:0004346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glucose-6-phosphate phosphohydrolase activity
GO:0004346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-6-phosphatase activity
GO:0004346	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucose 6-phosphate phosphatase activity
REACT:R-GGA-8857583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by PTK6 (Gallus gallus)
REACT:R-SPO-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Schizosaccharomyces pombe)
REACT:R-BTA-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Bos taurus)
REACT:R-MMU-3371360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)
REACT:R-MMU-205238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 interacts with p-KIT (Mus musculus)
RHEA:14371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate + phosphate => 2-phosphoglycolate + H2O
REACT:R-PFA-110251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of hypoxanthine by MPG glycosylase (Plasmodium falciparum)
REACT:R-DRE-373730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neurofascin and NrCAM heterodimerization (Danio rerio)
RHEA:19669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H2O = GDP + H(+) + phosphate
RHEA:10763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> acetate + oxaloacetate
GO:0004064	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aromatic esterase
GO:0004064	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	A-esterase activity
GO:0004064	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aryl-ester hydrolase
GO:0004064	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	paraoxonase activity
GO:0004064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arylesterase activity
REACT:R-HSA-8939870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCMA gene expression is stimulated by RUNX2 and SP7 (Homo sapiens)
GO:0052686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	perillic acid-CoA ligase (AMP-forming) activity
GO:0052686	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	perillyl-CoA synthetase activity
GO:0052686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	perillic acid:CoA ligase (AMP-forming) activity
EC:2.4.1.384	skos:prefLabel	"NDP-glycosyltransferase"
EC:2.4.1.384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NDP-glycosyltransferase"
RHEA:26463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine => 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine
GO:0015264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylammonium channel activity
REACT:R-XTR-1482861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL is acylated to CL by LCLAT1 (ER) (Xenopus tropicalis)
REACT:R-CFA-428007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled histidine and di-peptide cotransport (Canis familiaris)
REACT:R-RNO-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Rattus norvegicus)
RHEA:13516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + NAD(+) <=> H(+) + NADH + orotate
REACT:R-CFA-2395340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxyallysine by LOX (Canis familiaris)
REACT:R-CFA-372448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Canis familiaris)
RHEA:10735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + firefly D-luciferin + O2 <=> AMP + CO2 + diphosphate + firefly oxyluciferin + hnu
REACT:R-CFA-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Canis familiaris)
RHEA:50483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]
GO:0035368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SECIS binding
GO:0035368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenocysteine insertion sequence binding
REACT:R-MMU-109638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Mus musculus)
RHEA:71141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+) => acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH
REACT:R-BTA-1855172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Bos taurus)
REACT:R-RNO-3159259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAA:MUT binds AdoCbl (Rattus norvegicus)
REACT:R-XTR-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)
RHEA:22801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cycloeucalenol => obtusifoliol
REACT:R-RNO-9733545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts and acids bind ALB (Rattus norvegicus)
REACT:R-SSC-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Sus scrofa)
REACT:R-RNO-8956568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the core TAL1 complex (Rattus norvegicus)
REACT:R-HSA-9018572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates NOTCH3 (Homo sapiens)
REACT:R-SCE-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Saccharomyces cerevisiae)
REACT:R-RNO-8848110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOCS3 binds activated PTK6 (Rattus norvegicus)
RHEA:70190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose <=> cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose
RHEA:39497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH
RHEA:35676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-serine + tetradecanoyl-CoA => 3-oxohexadecasphinganine + CO2 + CoA
GO:0043907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cys-tRNAPro hydrolase activity
GO:0043907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cys-tRNA(Pro) deacetylase activity
GO:0043907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cys-tRNA(Pro) hydrolase activity
REACT:R-SSC-751019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:G12/13 complex dissociates (Sus scrofa)
REACT:R-DRE-8875183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates activated MET (Danio rerio)
RHEA:67274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+) => 1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O
RHEA:36696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid => desmethyldescarbamoylnovobiocin + dTDP + H(+)
RHEA:14376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]
REACT:R-DRE-1981157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucosylation of collagen propeptide hydroxylysines (Danio rerio)
RHEA:17347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + methylmalonate => (S)-methylmalonyl-CoA + H2O
RHEA:29547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-N-acetyl-alpha-D-glucosamine = 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP
REACT:R-RNO-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Rattus norvegicus)
RHEA:34143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabinerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2
REACT:R-CEL-8875659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Caenorhabditis elegans)
REACT:R-CFA-4641256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated AXIN is degraded by the proteasome (Canis familiaris)
RHEA:16130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + pyridoxine => H(+) + NADPH + pyridoxal
GO:0034601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxoglutarate dehydrogenase [NAD(P)+] activity
REACT:R-BTA-9014467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG binds effectors at the ER membrane (Bos taurus)
RHEA:17116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-serine-phosphoethanolamine <=> H(+) + L-serine + phosphoethanolamine
REACT:R-MMU-1602377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Mus musculus)
REACT:R-MMU-447074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)
REACT:R-CFA-8932851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Canis familiaris)
RHEA:10057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-aminobutanoyl-CoA => (2E)-butenoyl-CoA + NH4(+)
REACT:R-MMU-389759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP-1 or SHP-2 with phospho PD-1 (Mus musculus)
REACT:R-BTA-190258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c binds to FGF (Bos taurus)
REACT:R-DME-8982017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (q) binds RGS proteins (Drosophila melanogaster)
RHEA:14728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate
REACT:R-CFA-418091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R binds ARRB1 (Canis familiaris)
RHEA:40759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate
REACT:R-CEL-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Caenorhabditis elegans)
RHEA:58792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + Fe(III)-petrobactin(out) + H2O = ADP + Fe(III)-petrobactin(in) + H(+) + phosphate
REACT:R-GGA-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)
REACT:R-HSA-913725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	viral dsRNA binds IFIH1:TKFC (Homo sapiens)
RHEA:58613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-ascorbate + N-octanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine
REACT:R-HSA-6805426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARD8 binds CASP9(1-416) (Homo sapiens)
REACT:R-DRE-8944220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXIII (Danio rerio)
RHEA:38068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA
RHEA:72004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(in) + urate(out) => (S)-lactate(out) + urate(in)
REACT:R-XTR-190408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2b (Xenopus tropicalis)
REACT:R-MMU-6800035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP3 binds TMEM219 (Mus musculus)
REACT:R-DME-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Drosophila melanogaster)
RHEA:55053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pentanoyl-CoA => CoA + H(+) + pentanoate
RHEA:62103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate
REACT:R-HSA-8853405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPX2 binds AURKA at centrosomes (Homo sapiens)
RHEA:60261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine
REACT:R-DRE-2395818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)
RHEA:69544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptidine = 6-O-adenylylstreptidine + diphosphate
REACT:R-MMU-5626220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 binds the mother centriole (Mus musculus)
REACT:R-RNO-200729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports FOLA from extracellular region to cytosol (Rattus norvegicus)
REACT:R-HSA-2220944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)
REACT:R-CFA-158784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Canis familiaris)
RHEA:67043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) <=> asnovolin H
REACT:R-DDI-8943003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH polyubiquitinates monoubiquitinated PCNA (Dictyostelium discoideum)
RHEA:33728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine => a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)
REACT:R-CEL-8871196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)
REACT:R-HSA-8964588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNA2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)
GO:0018722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenanthrol sulfotransferase activity
GO:0018722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phenanthrol sulphotransferase activity
REACT:R-HSA-9679028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 binds JAK3 inhibitors (Homo sapiens)
REACT:R-RNO-8944349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE tetramers bind TCF/LEF at WNT promoters (Rattus norvegicus)
RHEA:55511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-9018572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates NOTCH3 (Rattus norvegicus)
RHEA:40470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)
RHEA:53262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone
RHEA:34569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-paratose + NADP(+)
REACT:R-GGA-2032775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD1 (Gallus gallus)
REACT:R-RNO-1482907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Rattus norvegicus)
REACT:R-CEL-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-DRE-5672969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF (Danio rerio)
GO:0047956	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol:NADP+ oxidoreductase activity
GO:0047956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol dehydrogenase [NADP+] activity
GO:0047956	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol dehydrogenase (NADP+) activity
REACT:R-DME-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Drosophila melanogaster)
REACT:R-MMU-984671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chromokinesins form dimers (Mus musculus)
REACT:R-SSC-8848818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CBL (Sus scrofa)
REACT:R-BTA-5696914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP28 deubiquitinates CLSPN and MYC (Bos taurus)
GO:0080083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-gentiobiose beta-glucosidase activity
REACT:R-MTU-879298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate (Mycobacterium tuberculosis)
REACT:R-BTA-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Bos taurus)
REACT:R-XTR-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)
REACT:R-DRE-9617370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-antagonists bind ADRA1A,B,D (Danio rerio)
RHEA:19223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate + H(+) + methanol => 2 formaldehyde + H2O
REACT:R-MMU-198563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO1 dioxygenates L-Trp to NFK (Mus musculus)
GO:0034811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzo(a)pyrene 9,10-dioxygenase activity
GO:0102744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-geranyl-geranyl diphosphate reductase activity
REACT:R-GGA-9640175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Gallus gallus)
REACT:R-SPO-8862137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B2 oxidises estradiol (E2) to estrone (E1) (Schizosaccharomyces pombe)
RHEA:51459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-isoleucine <=> (9Z)-octadecenoate + L-isoleucine
RHEA:70130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
GO:0047748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanetetrol 26-dehydrogenase activity
GO:0047748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity
GO:0047748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanetetraol 26-dehydrogenase activity
GO:0047748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity
GO:0047748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TEHC-NAD oxidoreductase activity
RHEA:16098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylpyruvate + H2O => acetate + H(+) + pyruvate
RHEA:31614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene <=> H2O + rhodopin
GO:0005049	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	importin-alpha export receptor activity
GO:0005049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	importin-alpha binding
GO:0005049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NES receptor
GO:0005049	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exportin activity
GO:0005049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear export signal receptor activity
GO:0061659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein ligase activity
GO:0061659	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0061659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conjugating protein ligase activity
REACT:R-RNO-9013109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GEFs activate RHOC (Rattus norvegicus)
RHEA:36533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA => (13Z)-docosenoyl-CoA + H(+) + malonyl-CoA
RHEA:60871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP
REACT:R-GGA-9702818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds erenumab (Gallus gallus)
REACT:R-CEL-9013452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP translocates to the endosome membrane (Caenorhabditis elegans)
RHEA:13092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) <=> 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite
EC:1.1.1.134	skos:prefLabel	"dTDP-6-deoxy-L-talose 4-dehydrogenase"
EC:1.1.1.134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-6-deoxy-L-talose 4-dehydrogenase"
REACT:R-SPO-109624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Schizosaccharomyces pombe)
RHEA:38361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiosulfate + ubiquinol-10 => 2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10
REACT:R-GGA-5668731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX3 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)
REACT:R-CFA-446364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Migfilin interacts with VASP (Canis familiaris)
REACT:R-RNO-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)
REACT:R-BTA-749456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
RHEA:71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine(in) => L-ornithine(out)
GO:0003789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin depolymerizing activity
GO:0003789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin filament severing activity
REACT:R-MMU-156910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eEF1B complex (Mus musculus)
REACT:R-BTA-388833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CTLA-4 (Bos taurus)
REACT:R-PFA-73569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN oxidises (S)-DHO to orotate (Plasmodium falciparum)
REACT:R-SSC-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Sus scrofa)
REACT:R-RNO-5218814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 autophorylates (Rattus norvegicus)
REACT:R-BTA-265682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Bos taurus)
GO:0008785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkyl hydroperoxide reductase activity
REACT:R-BTA-170672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Bos taurus)
RHEA:51028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = 7-chloroindole-3-pyruvate imine dimer + 2 H2O
RHEA:42784	skos:prefLabel	"23S rRNA (adenine(2085)-N(6))-dimethyltransferase"
RHEA:42784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine
RHEA:42784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA (adenine(2085)-N(6))-dimethyltransferase"
REACT:R-MMU-177923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sustained activation of SRC kinase by SHP2 (Mus musculus)
REACT:R-HSA-1222594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mycothiol scavenges nitrosyl (Homo sapiens)
REACT:R-SSC-5654560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Sus scrofa)
REACT:R-CEL-191414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)
REACT:R-BTA-6798372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates DYRK2 (Bos taurus)
RHEA:66645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => diphosphate + trichobrasilenol
REACT:R-GGA-5694410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMED2:TMED10 tetramer binds GPI anchored proteins (Gallus gallus)
RHEA:15620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(3+) + Fe(II)-[cytochrome c] <=> Fe(2+) + Fe(III)-[cytochrome c]
RHEA:43106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + an N-acyleicosasphing-4-enine + 2 H2O => AH2 + an N-acyleicosasphinganine + O2
REACT:R-DRE-1234163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Danio rerio)
REACT:R-SSC-187916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Sus scrofa)
REACT:R-DRE-429798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Danio rerio)
REACT:R-DME-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Drosophila melanogaster)
RHEA:39326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)
REACT:R-DRE-8952382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 polyubiquitinates RUNX3 (Danio rerio)
REACT:R-DRE-9650858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Meglitinides bind ABCC8 (Danio rerio)
REACT:R-GGA-5624473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Gallus gallus)
RHEA:64675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(methylsulfanyl)acetyl-CoA + butan-1-ol <=> butyl 2-(methylsulfanyl)acetate + CoA
REACT:R-BTA-8848596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 binds PXN (Bos taurus)
RHEA:13576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate <=> [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP
RHEA:16791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H2O2 => a (2S)-2-hydroxycarboxylate + O2
RHEA:12934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuculose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate
REACT:R-DDI-1855232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Dictyostelium discoideum)
REACT:R-GGA-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Gallus gallus)
REACT:R-BTA-388830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds ICOS (Bos taurus)
REACT:R-SSC-8933547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCAT transfers Mal from Mal-CoA to NDUFAB1 (Sus scrofa)
REACT:R-HSA-443894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXA2 is hydrolysed to TXB2 (Homo sapiens)
REACT:R-XTR-5655170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCHY1 monoubiquitinates POLH (Xenopus tropicalis)
REACT:R-CEL-418850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 (Caenorhabditis elegans)
RHEA:68521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => beta-acoradiene + diphosphate
REACT:R-XTR-5672961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates inactive RAFs (Xenopus tropicalis)
REACT:R-XTR-192160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Xenopus tropicalis)
GO:0061607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide alpha-N-propionyltransferase activity
GO:0061607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal propionyltransferase activity
RHEA:15817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate
RHEA:24459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ribazole 5'-phosphate + H2O <=> alpha-ribazole + phosphate
RHEA:44963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-decenoyl-CoA + H(+) + NADPH <=> decanoyl-CoA + NADP(+)
RHEA:60104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-(aryl)acrylate reductase"
RHEA:60104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein] = (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]
RHEA:60104	skos:prefLabel	"3-(aryl)acrylate reductase"
REACT:R-BTA-6799604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Bos taurus)
REACT:R-RNO-9684627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds CYSLTR1 antagonists (Rattus norvegicus)
GO:0043770	skos:prefLabel	"demethylmenaquinone methyltransferase"
GO:0043770	skos:altLabel	"demethylmenaquinone C-methylase"
GO:0043770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylmenaquinone methyltransferase activity
GO:0043770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethylmenaquinone methyltransferase"
GO:0043770	skos:altLabel	"2-heptaprenyl-1,4-naphthoquinone methyltransferase"
GO:0043770	skos:altLabel	"2-demethylmenaquinone methyltransferase"
REACT:R-DRE-2160892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Danio rerio)
RHEA:53852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycocholate + NAD(+) = 7-oxo-glycodeoxycholate + H(+) + NADH
REACT:R-HSA-418549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKG1 phosphorylates BK channels (Homo sapiens)
REACT:R-MMU-266315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT + spherical HDL <=> LCAT:spherical HDL complex (Mus musculus)
RHEA:53008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di-trans,poly-cis-polyprenyl diphosphate + n diphosphate
RHEA:53008	skos:altLabel	"dehydrodolichyl diphosphate synthase 1"
RHEA:53008	skos:prefLabel	"ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]"
RHEA:53008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]"
RHEA:53008	skos:altLabel	"Rer2p Z-prenyltransferase"
RHEA:28026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + dUDP + H2O = [thioredoxin]-dithiol + UDP
REACT:R-DRE-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Danio rerio)
REACT:R-DRE-9013147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 GDIs block activation of RAC1 (Danio rerio)
REACT:R-DME-216072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Drosophila melanogaster)
RHEA:29998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + putrescine(out) <=> ADP + H(+) + phosphate + putrescine(in)
EC:3.1.13.4	skos:prefLabel	"poly(A)-specific ribonuclease"
EC:3.1.13.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"poly(A)-specific ribonuclease"
RHEA:53927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary amine + S-adenosyl-L-methionine <=> a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9672158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers (Homo sapiens)
REACT:R-GGA-353298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of repair proteins and ligation of the processed ends of the DNA double-strand break (Gallus gallus)
GO:0047456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylisocitrate dehydratase activity
GO:0047456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]
GO:0047456	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity
RHEA:72581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O
REACT:R-CFA-194130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport (influx) of bile salts and acids by OATP-A (Canis familiaris)
GO:0140483	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	inner kinetochore adaptor activity
GO:0140483	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	outer kinetochore adaptor activity
GO:0140483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinetochore adaptor activity
GO:0050629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + chloride + H(+) + trichloroethene = AH2 + tetrachloroethene
GO:0050629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetrachloroethene reductive dehalogenase"
GO:0050629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tetrachloroethene reductase activity
GO:0050629	skos:prefLabel	"tetrachloroethene reductive dehalogenase"
GO:0050629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrachloroethene reductive dehalogenase activity
GO:0050629	skos:altLabel	"tetrachloroethene reductase"
GO:0050629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acceptor:trichloroethene oxidoreductase (chlorinating)
REACT:R-DME-5672951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive RAFs bind YWHAB (Drosophila melanogaster)
REACT:R-HSA-1602374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Homo sapiens)
RHEA:66844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] = asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 2-oxoglutarate + gibberellin A53 + 3 O2 = 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate
GO:0033917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exopolygalacturonosidase activity
GO:0033917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exopolygalacturanosidase activity
GO:0033917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exo-poly-alpha-galacturonosidase activity
REACT:R-GGA-3134800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING dimerization (Gallus gallus)
RHEA:55351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol <=> 9-cis-retinol
REACT:R-MMU-9698844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds HSP90:CDC37 (Mus musculus)
REACT:R-BTA-399998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
REACT:R-SSC-202165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ITAM motifs in CD3 complexes (Sus scrofa)
RHEA:34012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydroepisterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2
REACT:R-BTA-376123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM associates with Rac1-GTP:pPAK1 (Bos taurus)
REACT:R-DRE-9700200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRZ dephosphorylates ligand-bound ALK dimers (Danio rerio)
REACT:R-HSA-2046092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Homo sapiens)
RHEA:41470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-DME-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Drosophila melanogaster)
REACT:R-MMU-3371527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1 trimer translocates to the nucleus (Mus musculus)
REACT:R-HSA-1912410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH4 mRNA translation controlled by miRNAs (Homo sapiens)
REACT:R-DME-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Drosophila melanogaster)
GO:0097163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur carrier activity
RHEA:71376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + testosterone 17-sulfate(out) => 2 Na(+)(in) + testosterone 17-sulfate(in)
REACT:R-DME-2022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to heparan (Drosophila melanogaster)
REACT:R-XTR-5676596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF3 binds BAFFR:BAFF (Xenopus tropicalis)
RHEA:27814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate(in) + Na(+)(in) = acetate(out) + Na(+)(out)
REACT:R-DME-204364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO1 binds SLIT2 (Drosophila melanogaster)
REACT:R-RNO-1008200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2 binds the beta globin locus control region (Rattus norvegicus)
GO:0047181	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity
GO:0047181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahydroxybenzophenone synthase activity
REACT:R-DRE-112383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Danio rerio)
RHEA:49866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (+)-dehydrodiconiferyl acid + 2 a quinone + H2O
RHEA:49740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NADP(+)
REACT:R-CEL-199443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Caenorhabditis elegans)
REACT:R-SCE-1676141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)
REACT:R-CEL-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Caenorhabditis elegans)
RHEA:57610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chlorocatechol + H(+) + NADH => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)
REACT:R-DRE-6809254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR8 binds MTMR9 (Danio rerio)
REACT:R-DME-72127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Spliceosomal B Complex (Drosophila melanogaster)
REACT:R-CFA-9653514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17L2 deubiquitinates RCE1 (Canis familiaris)
REACT:R-XTR-198824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Xenopus tropicalis)
REACT:R-MMU-5669013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA-3 binds EDA2R (Mus musculus)
REACT:R-BTA-9698844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds HSP90:CDC37 (Bos taurus)
REACT:R-RNO-216723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Rattus norvegicus)
RHEA:33691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate
GO:0032182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-like protein binding
GO:0032182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	small conjugating protein binding
REACT:R-MMU-177936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Mus musculus)
GO:0047421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acyl-D-glutamate amidohydrolase activity
GO:0047421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acyl-D-glutamate deacylase activity
RHEA:58427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hex-2-en-1-ol + NADP(+) <=> (E)-hex-2-enal + H(+) + NADPH
RHEA:57389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:27951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine(in) => L-phenylalanine(out)
REACT:R-GGA-5358599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Gallus gallus)
RHEA:70772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-1602454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proMMP9 binds TIMP1 (Homo sapiens)
RHEA:52904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,17(3)-seco-F430-17(3)-acid + ATP = ADP + coenzyme F430 + phosphate
RHEA:52904	skos:prefLabel	"coenzyme F430 synthetase"
RHEA:52904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coenzyme F430 synthetase"
REACT:R-HSA-379980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)
RHEA:59320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellobiono-1,5-lactone + H2O = 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)
RHEA:46413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:59855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)
REACT:R-RNO-9614562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO3 (Rattus norvegicus)
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M2 muscarinic acetylcholine receptor binding
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M1 muscarinic acetylcholine receptor binding
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M3 muscarinic acetylcholine receptor ligand
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	muscarinic acetylcholine receptor ligand
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled acetylcholine receptor binding
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M4 muscarinic acetylcholine receptor ligand
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled acetylcholine receptor binding
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M1 muscarinic acetylcholine receptor ligand
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	muscarinic acetylcholine receptor binding
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M5 muscarinic acetylcholine receptor binding
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M2 muscarinic acetylcholine receptor ligand
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M5 muscarinic acetylcholine receptor ligand
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M4 muscarinic acetylcholine receptor binding
GO:0031789	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	M3 muscarinic acetylcholine receptor binding
RHEA:50453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H3 => prostaglandin E3
REACT:R-DDI-9634834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACHEIs bind ACHE (Dictyostelium discoideum)
REACT:R-BTA-166214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion flip-flops to the opposite surface (Bos taurus)
REACT:R-HSA-1181155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The NODAL Receptor binds NODAL ligands (Homo sapiens)
REACT:R-CFA-909722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-STAT2:p-STAT1 dimer (Canis familiaris)
RHEA:39162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O
RHEA:45029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]
RHEA:50778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hex-2-enal + H(+) + NADPH => hexanal + NADP(+)
REACT:R-BTA-391943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLT2 binds LTC4,LTD4,LTE4 (Bos taurus)
GO:0103072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity
REACT:R-HSA-174452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)
RHEA:50638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 3-(omega-methylsulfanyl)alkylmalate
REACT:R-RNO-2161791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Rattus norvegicus)
RHEA:32730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain acyl-CoA + H(+) + malonyl-CoA <=> a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
REACT:R-MMU-5654634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates SHC1 (Mus musculus)
REACT:R-SSC-9014454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOG translocates to the ER membrane (Sus scrofa)
RHEA:12104	skos:prefLabel	"thymidylate synthase"
RHEA:12104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thymidylate synthase"
RHEA:12104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP
REACT:R-DDI-70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Dictyostelium discoideum)
REACT:R-BTA-437136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A8 transports Zn2+ from cytosol to secretory granule (Bos taurus)
REACT:R-MMU-9661417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Mus musculus)
REACT:R-RNO-8856189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF8 binds TNFRSF8 (Rattus norvegicus)
RHEA:35140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + demethoxycurcumin
RHEA:37174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-CFA-4093327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHA binds TIAM1 (Canis familiaris)
RHEA:64912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate
REACT:R-CEL-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Caenorhabditis elegans)
RHEA:38033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)
REACT:R-SCE-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)
RHEA:71886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide
RHEA:63751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan-2-N-beta-D-glucuronide
REACT:R-HSA-9706345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Homo sapiens)
REACT:R-GGA-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Gallus gallus)
REACT:R-DRE-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
RHEA:49320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin = (5R,6S)-5,6-epoxi-capsanthin
RHEA:37877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl aklanonate + S-adenosyl-L-homocysteine => aklanonate + S-adenosyl-L-methionine
GO:0050607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD/factor-dependent formaldehyde dehydrogenase activity
GO:0050607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycothiol-dependent formaldehyde dehydrogenase activity
GO:0050607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)
REACT:R-BTA-8870499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLEKHA3,8 bind PI4P, ARF1 (Bos taurus)
REACT:R-HSA-182243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MHC I:Nef Complex (Homo sapiens)
REACT:R-RNO-2314686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASA- acetylates PTGS2 (Rattus norvegicus)
REACT:R-RNO-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Rattus norvegicus)
RHEA:54488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine
RHEA:66837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] => asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]
EC:7.6.2.-	skos:prefLabel	"Linked to the hydrolysis of a nucleoside triphosphate"
EC:7.6.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Linked to the hydrolysis of a nucleoside triphosphate"
REACT:R-SCE-9632858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCZ autophosphorylates downstream of estrogen stimulation (Saccharomyces cerevisiae)
REACT:R-BTA-2213201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibres (Bos taurus)
REACT:R-CFA-2396370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds collagens II, III and V (Canis familiaris)
REACT:R-SSC-6803545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to phagosomal lumen (Sus scrofa)
REACT:R-CFA-9731632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)
REACT:R-MMU-9688832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds PDCD6IP and SDCBP (Mus musculus)
REACT:R-HSA-5693564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
REACT:R-MMU-9007283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX3 and PRC1.6 associate with E2F6.com-1 (Mus musculus)
REACT:R-SSC-9756134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Sus scrofa)
REACT:R-HSA-201634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of FADK 1 (Homo sapiens)
REACT:R-GGA-111925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP induces dissociation of inactive PKA tetramers (Gallus gallus)
REACT:R-SCE-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Saccharomyces cerevisiae)
RHEA:50918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + an aldehyde + diphosphate + NADP(+) => a carboxylate + ATP + H(+) + NADPH
RHEA:30391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylsulfanyl-2-oxobutanoate + L-glutamine = 2-oxoglutaramate + L-methionine
RHEA:30391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glutamine--4-(methylsulfanyl)-2-oxobutanoate aminotransferase"
RHEA:30391	skos:prefLabel	"L-glutamine--4-(methylsulfanyl)-2-oxobutanoate aminotransferase"
REACT:R-CFA-9701147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 blockers (Canis familiaris)
RHEA:56981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzyl alcohol + 2 oxidized [azurin] => 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]
RHEA:14392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
REACT:R-RNO-9603989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Rattus norvegicus)
REACT:R-BTA-5654416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:pFRS binds GRB2:SOS1 (Bos taurus)
REACT:R-CFA-449077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-16 is secreted (Canis familiaris)
RHEA:40286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + hexadecanedioyl-CoA <=> CoA + O-hexadecanedioyl-L-carnitine
REACT:R-HSA-2187325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)
REACT:R-MMU-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Mus musculus)
RHEA:37909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8E,10S)-10-hydroperoxy-octadeca-8-enoate => (9Z)-octadecenoate + O2
REACT:R-RNO-983147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
GO:0017129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triacylglycerol binding
GO:0017129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	triglyceride binding
REACT:R-DRE-181450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Danio rerio)
REACT:R-SCE-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Saccharomyces cerevisiae)
RHEA:42416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + L-proline = (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)
RHEA:71843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tauroursodeoxycholate(out) = tauroursodeoxycholate(in)
RHEA:40310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + decanedioyl-CoA <=> (2E)-decenedioyl-CoA + AH2
RHEA:29529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
REACT:R-DDI-8956045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)
REACT:R-MMU-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Mus musculus)
RHEA:15757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH
REACT:R-DME-419334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melatonin receptors can bind melatonin (Drosophila melanogaster)
RHEA:20101	skos:prefLabel	"long-chain-fatty-acid--protein ligase"
RHEA:20101	skos:altLabel	"acyl-protein synthetase"
RHEA:20101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain-fatty-acid--protein ligase"
RHEA:20101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + L-cysteinyl-[protein] = AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]
GO:0042162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomeric repeat binding
GO:0042162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomeric DNA binding
GO:0042162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	telomere binding
REACT:R-HSA-163733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of FAS monomer gene by ChREBP:MLX (Homo sapiens)
RHEA:62884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 4 semiviriditoxin = 2 (M)-viriditoxin + 2 H2O
GO:0102484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esculetin glucosyltransferase activity
REACT:R-HSA-174120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)
REACT:R-CEL-3928607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EPHs bind VAV2,3 (Caenorhabditis elegans)
REACT:R-SCE-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Saccharomyces cerevisiae)
RHEA:32258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)
REACT:R-DRE-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Danio rerio)
REACT:R-SSC-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Sus scrofa)
REACT:R-BTA-5674132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Bos taurus)
RHEA:45028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]
RHEA:45028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2S)-methylsuccinyl-CoA dehydrogenase"
RHEA:45028	skos:prefLabel	"(2S)-methylsuccinyl-CoA dehydrogenase"
RHEA:22031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + taxa-4(20),11-dien-5alpha-ol <=> CoA + taxa-4(20),11-dien-5alpha-yl acetate
REACT:R-MMU-9614031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class IV antihypertensives bind LTCC multimer (Mus musculus)
REACT:R-SPO-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Schizosaccharomyces pombe)
REACT:R-CFA-427527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNoSC dimethylates histone H3 at lysine-9 (Canis familiaris)
RHEA:72563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) + dehydroepiandrosterone 3-sulfate(in) = butanoate(in) + dehydroepiandrosterone 3-sulfate(out)
RHEA:37549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-D-glucose 6-phosphate + H(+) + NADH => D-glucose 6-phosphate + NAD(+)
RHEA:19447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + CO2 + H(+) => 2,3-dihydroxyindole + O2
RHEA:52052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + hexadecanoate
REACT:R-BTA-8849345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Bos taurus)
RHEA:11923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O
REACT:R-XTR-6781797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP19 binds HIF1A,BIRC2,BIRC3 (Xenopus tropicalis)
RHEA:10622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamoyl-CoA + H(+) + NADPH => (E)-cinnamaldehyde + CoA + NADP(+)
RHEA:71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-isoleucine(out) + 2 Na(+)(out) = chloride(in) + L-isoleucine(in) + 2 Na(+)(in)
REACT:R-BTA-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Bos taurus)
RHEA:36993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,5-bisphosphate + uracil => phosphate + UMP
RHEA:54113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => diphosphate + selina-4(15),7(11)-diene
REACT:R-MMU-8948709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Mus musculus)
RHEA:23471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminobenzenesulfonate + 2 H(+) + NADH + O2 <=> 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)
REACT:R-HSA-5668545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIK autophosphorylates on T559 (Homo sapiens)
RHEA:71835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) = estrone 3-sulfate(in)
RHEA:13288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-cysteine + L-glutamate <=> ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate
REACT:R-HSA-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Homo sapiens)
REACT:R-BTA-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Bos taurus)
REACT:R-SSC-453200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Sus scrofa)
GO:0034603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate dehydrogenase [NAD(P)+] activity
RHEA:26245	skos:prefLabel	"fusicocca-2,10(14)-diene synthase"
RHEA:26245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	geranylgeranyl diphosphate = diphosphate + fusicocca-2,10(14)-diene
RHEA:26245	skos:altLabel	"fusicoccadiene synthase"
RHEA:26245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fusicocca-2,10(14)-diene synthase"
REACT:R-HSA-5244506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
REACT:R-XTR-209891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine is oxidised to noradrenaline (Xenopus tropicalis)
REACT:R-HSA-9665697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)
REACT:R-BTA-5213466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is phosphorylated (Bos taurus)
REACT:R-BTA-8857555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates GPNMB (Bos taurus)
REACT:R-XTR-163099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alignment Of The RNA Template On The Telomeric Chromosome End (Xenopus tropicalis)
RHEA:62379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-didehydro-3-deoxy-L-rhamnonate + H2O <=> (S)-lactate + H(+) + pyruvate
RHEA:70207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinga-4E,14Z-dienine-1-phosphate(in) = sphinga-4E,14Z-dienine-1-phosphate(out)
REACT:R-RNO-5672980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF complex (Rattus norvegicus)
RHEA:36172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + a long chain fatty alcohol => 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)
REACT:R-GGA-9693478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR1A binds HTR1A agonists (Gallus gallus)
RHEA:68752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]
REACT:R-HSA-5682863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF168 binds DNA DSBs (Homo sapiens)
RHEA:36663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA = (2S,5S)-5-carboxymethylproline + CO2 + CoA
RHEA:36663	skos:prefLabel	"carboxymethylproline synthase"
RHEA:36663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carboxymethylproline synthase"
REACT:R-CFA-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
RHEA:52830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-isodihydrocarvone + H(+) + NADPH + O2
REACT:R-MMU-2203479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2 (FEEL-2) binds ligands (Mus musculus)
REACT:R-HSA-901039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN1B1 hydrolyses 1,2-linked mannose (c branch) (Homo sapiens)
REACT:R-HSA-9706319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA (Homo sapiens)
RHEA:10073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylglycine + S-adenosyl-L-methionine => glycine betaine + H(+) + S-adenosyl-L-homocysteine
RHEA:42247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-[ACP] + propanoyl-CoA <=> 3-oxopentanoyl-[ACP] + CO2 + CoA
REACT:R-MMU-2162066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbovir + IMP => carbovir monophosphate + inosine (Mus musculus)
REACT:R-XTR-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Xenopus tropicalis)
REACT:R-DRE-2467794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resolution of sister chromatids (Danio rerio)
REACT:R-MMU-5610766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Mus musculus)
REACT:R-RNO-2294580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 hyperphosphorylates Condensin II complex (Rattus norvegicus)
REACT:R-MMU-508163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Mus musculus)
REACT:R-DRE-198266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K produces PIP3 and other phosphatidyl inositides (Danio rerio)
REACT:R-SSC-9648949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A antagonists bind HTR3A pentamer (Sus scrofa)
REACT:R-BTA-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Bos taurus)
RHEA:20758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA => (E)-caffeoyl-CoA + D-threo-isocitrate
GO:0010177	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	methylthioalkylmalate synthase activity
GO:0010177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2'-methylthio)ethylmalate synthase activity
RHEA:21741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate
RHEA:11454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-XTR-9013004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the ER membrane (Xenopus tropicalis)
RHEA:31122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA <=> (2E)-2-methylbut-2-enoyl-CoA + H2O
REACT:R-DME-8956040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
RHEA:56217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP
REACT:R-GGA-9690493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors on endosomes (Gallus gallus)
REACT:R-RNO-5694462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD6,12 hydrolyse 3AG (Rattus norvegicus)
REACT:R-HSA-5687758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP4C:PPP4R2 dephosphorylates RPA2 (Homo sapiens)
EC:1.1.1.47	skos:prefLabel	"glucose 1-dehydrogenase [NAD(P)(+)]"
EC:1.1.1.47	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucose 1-dehydrogenase [NAD(P)(+)]"
RHEA:49166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine => a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine
REACT:R-DRE-199959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by protein phosphatase 2A (Danio rerio)
REACT:R-HSA-163213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of electrons through the succinate dehydrogenase complex (Homo sapiens)
REACT:R-GGA-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Gallus gallus)
REACT:R-CFA-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)
REACT:R-CFA-2029457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIIA with IgG-coated Ag (Canis familiaris)
REACT:R-DDI-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)
REACT:R-XTR-6801328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Xenopus tropicalis)
RHEA:35442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine <=> archaetidylserine + CMP + H(+)
RHEA:27940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + glyoxylate => (3R)-3-hydroxy-D-aspartate
REACT:R-CFA-5164399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCO2:Fe2+ cleaves betaC to APO10al and bION (Canis familiaris)
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MLTKb
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MEKK2
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cMos
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MLTKa
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MEK kinase activity
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAP3K
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	STK28
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein phosphotransferase (MAPKKKK-activated) activity
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MEKK1
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mil/Raf
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cRaf
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP kinase kinase kinase activity
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MEKK3
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MEKK
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	MLK-like mitogen-activated protein triple kinase activity
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mitogen-activated protein kinase kinase kinase activity
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEKK activity
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MAPKKK activity
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	REKS
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK/ERK kinase kinase activity
GO:0004709	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MLTK
REACT:R-DME-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)
REACT:R-HSA-427528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)
REACT:R-MMU-176101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Rad17-RFC complex to DNA (Mus musculus)
RHEA:51350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine => acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine
REACT:R-HSA-9753632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Homo sapiens)
REACT:R-HSA-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Homo sapiens)
RHEA:16622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrosanguinarine + H(+) + O2 => H2O2 + sanguinarine
REACT:R-CEL-114542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1,RAC2,RHOG activate PI3K (Caenorhabditis elegans)
RHEA:24167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]
RHEA:65182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + preaustinoid A => AH2 + O2 + protoaustinoid B
REACT:R-SSC-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Sus scrofa)
RHEA:42079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + acetyl-CoA <=> 2-hydroxyglutaryl-CoA + acetate
RHEA:36008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-MMU-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Mus musculus)
RHEA:67261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-hept-2-enal + H2O + NAD(+) => (E)-hept-2-enoate + 2 H(+) + NADH
RHEA:34951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate(out) = 3-hydroxypropanoate(in)
GO:0071522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ureidoglycine aminohydrolase activity
REACT:R-BTA-8865454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBFB binds RUNX3 (Bos taurus)
RHEA:52375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CFA-432706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Canis familiaris)
REACT:R-SPO-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Schizosaccharomyces pombe)
RHEA:21946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+) => ATP + D-cellobiose
REACT:R-HSA-9661397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)
RHEA:54677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate => (+)-kolavenyl diphosphate
REACT:R-SSC-446189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second glucose to the N-glycan precursor by ALG8 (Sus scrofa)
REACT:R-SSC-77254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Sus scrofa)
RHEA:51567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)
RHEA:27823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-acetyl-L-homoserine => acetate + L-homocysteine
RHEA:39760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-6811472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IER3 recruits MAPKs to PP2A-B56-beta,gamma (Rattus norvegicus)
REACT:R-HSA-1604350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14:TIMP2 binds proMMP2 (Homo sapiens)
RHEA:36280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NAD(+)
REACT:R-MMU-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Mus musculus)
RHEA:51596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"toluene methyl-monooxygenase"
RHEA:51596	skos:prefLabel	"toluene methyl-monooxygenase"
RHEA:51596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-CEL-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Caenorhabditis elegans)
REACT:R-HSA-449077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-16 is secreted (Homo sapiens)
REACT:R-RNO-5654633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS bind to PPTN11 (Rattus norvegicus)
RHEA:32498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:43929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pregn-5-ene-3,20-dione => progesterone
REACT:R-BTA-2106579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWTR1:SMAD translocates to the nucleus (Bos taurus)
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IBAGlu synthase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:indol-3-ylbutyrate glucosyltransferase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-butyrate beta-glucosyltransferase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine diphosphoglucose-indolebutyrate glucosyltransferase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IBA-Glc synthetase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDPG-indol-3-ylbutyryl glucosyl transferase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IBA-glucose synthase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-butyric acid glucosyltransferase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:indol-3-ylbutyrate glucosyl-transferase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indol-3-ylbutyrylglucose synthase activity
GO:0052638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:(indol-3-yl)butyrate beta-D-glucosyltransferase activity
REACT:R-DDI-1855185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)
RHEA:12967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phospho-alpha-D-galacturonate + ADP + H(+) => ATP + D-galacturonate
RHEA:60510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine => a guanosine in mRNA + S-adenosyl-L-methionine
RHEA:50030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine => H2O + tetradecanoyl-CoA
REACT:R-RNO-5654402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
REACT:R-SSC-9714694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 translocates to the endoplasmic reticulum membrane (Sus scrofa)
EC:3.4.23.35	skos:altLabel	"extracellular 'barrier' protein"
EC:3.4.23.35	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"barrierpepsin"
EC:3.4.23.35	skos:altLabel	"Bar proteinase"
EC:3.4.23.35	skos:prefLabel	"barrierpepsin"
RHEA:58702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADPH + rifampicin
REACT:R-HSA-3296304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR31 is a receptor for 12(S)-HETE (Homo sapiens)
RHEA:20532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisic aldehyde + H2O + O2 <=> 2-cis-(+)-abscisate + H(+) + H2O2
REACT:R-CFA-6782131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
REACT:R-HSA-3928656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves EPHB2 (Homo sapiens)
REACT:R-DRE-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Danio rerio)
REACT:R-RNO-450550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKCalpha phosphorylates HuR (Rattus norvegicus)
REACT:R-HSA-5218806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN autophosphorylates (Homo sapiens)
RHEA:52651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arabino-1,4-lactone 5-phosphate <=> 5-phospho-L-arabinonate + H(+)
RHEA:45731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeyl alcohol + NADP(+) <=> (E)-caffeyl aldehyde + H(+) + NADPH
REACT:R-DME-110350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of TDG glycosylase by APEX1 at the AP site (Drosophila melanogaster)
RHEA:43303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP
REACT:R-CFA-9024766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Canis familiaris)
RHEA:30766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-valine + NAD(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)
REACT:R-HSA-1295540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Homo sapiens)
RHEA:23208	skos:prefLabel	"glutaconate CoA-transferase"
RHEA:23208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutaconate CoA-transferase"
RHEA:23208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + trans-glutaconate = (2E)-glutaconyl-CoA + acetate
REACT:R-HSA-9729849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 nsp1 binds to 40S ribosomal complex (Homo sapiens)
REACT:R-MMU-1676162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Mus musculus)
RHEA:49728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADPH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NADP(+) + violacein
RHEA:49615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH
GO:0033888	skos:prefLabel	"chondro-6-sulfatase"
GO:0033888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate
GO:0033888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chondro-6-sulfatase"
GO:0033888	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity
GO:0033888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondro-6-sulfatase activity
RHEA:34209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose 1-phosphate + L-rhamnopyranose => 3-O-alpha-D-glucosyl-L-rhamnose + phosphate
REACT:R-MMU-5626953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds DENN/MADD (Mus musculus)
REACT:R-BTA-6789072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGLYRP1 binds bacterial peptidoglycan (Bos taurus)
REACT:R-CEL-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Caenorhabditis elegans)
REACT:R-HSA-9759358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2-dependent SRXN1 gene expression (Homo sapiens)
REACT:R-HSA-163825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
REACT:R-MMU-173483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAMBI interferes with the interaction of type I receptor with type II receptor (Mus musculus)
REACT:R-CFA-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Canis familiaris)
RHEA:45248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoate(out) = butanoate(in)
REACT:R-GGA-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Gallus gallus)
REACT:R-SSC-389632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Sus scrofa)
RHEA:69505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-D-glucosamine + O2 => H2O2 + N-acetyl-D-glucosamino-1,5-lactone
RHEA:45562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-allo-isoleucine => L-isoleucine
REACT:R-SSC-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Sus scrofa)
REACT:R-HSA-9021888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds CREB1 (Homo sapiens)
GO:0047648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkylamidase activity
GO:0047648	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-methylhexanamide amidohydrolase activity
GO:0044373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytokinin binding
RHEA:64865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITP + oxaloacetate => CO2 + IDP + phosphoenolpyruvate
REACT:R-MMU-8934735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 arginine-methylates RUNX1 (Mus musculus)
REACT:R-SSC-5672948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK3 phosphorylates KSR1 (Sus scrofa)
REACT:R-MMU-5661290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Mus musculus)
REACT:R-XTR-69019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm4,6,7 trimer forms and associates with the replication fork (Xenopus tropicalis)
REACT:R-BTA-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Bos taurus)
REACT:R-DDI-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Dictyostelium discoideum)
REACT:R-GGA-6797090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK12 (Gallus gallus)
RHEA:14436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a tRNA precursor + ATP + 2 CTP <=> a tRNA with a 3' CCA end + 3 diphosphate
REACT:R-DME-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Drosophila melanogaster)
REACT:R-GGA-353524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XP-C binds to RAD23B forming a heterodimer (Gallus gallus)
RHEA:42577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O => 2-methylpropanoate + 2-oxopent-4-enoate + H(+)
REACT:R-DME-1369065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Drosophila melanogaster)
RHEA:21011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) <=> diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH
GO:0003883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine triphosphate aminase activity
GO:0003883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine 5'-triphosphate synthetase activity
GO:0003883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine triphosphate synthetase activity
GO:0003883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP--ammonia ligase activity
GO:0003883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP synthase activity
GO:0003883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP synthetase activity
GO:0003883	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UTP:ammonia ligase (ADP-forming)
REACT:R-BTA-159868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor VII to factor VII (Bos taurus)
REACT:R-MMU-70837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Mus musculus)
REACT:R-HSA-1839078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic FGFR1 fusion proteins bind PIK3R1 (Homo sapiens)
RHEA:18617	skos:prefLabel	"phosphoenolpyruvate carboxykinase (ATP)"
RHEA:18617	skos:altLabel	"phosphoenolpyruvate carboxylase"
RHEA:18617	skos:altLabel	"phosphopyruvate carboxylase"
RHEA:18617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate
RHEA:18617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoenolpyruvate carboxykinase (ATP)"
RHEA:18617	skos:altLabel	"PEP carboxykinase"
RHEA:18617	skos:altLabel	"phosphoenolpyruvate carboxykinase"
RHEA:18617	skos:altLabel	"PEPCK"
RHEA:26277	skos:prefLabel	"cobalt-precorrin-4 methyltransferase"
RHEA:26277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobalt-precorrin-4 methyltransferase"
RHEA:26277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-193755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Sus scrofa)
RHEA:15061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH
REACT:R-CFA-5626699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK4 binds ODF2 in the centriole (Canis familiaris)
RHEA:52557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-D-erythronate + ATP => 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)
RHEA:48378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose
RHEA:23300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2Z,6E)-farnesyl diphosphate synthase"
RHEA:23300	skos:altLabel	"Z-farnesyl diphosphate synthase"
RHEA:23300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + isopentenyl diphosphate = (2Z,6E)-farnesyl diphosphate + diphosphate
RHEA:23300	skos:altLabel	"(Z)-farnesyl diphosphate synthase"
RHEA:23300	skos:prefLabel	"(2Z,6E)-farnesyl diphosphate synthase"
RHEA:25209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine = acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
REACT:R-MMU-9705714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 dehydrogenates TEST to DHTEST (Mus musculus)
REACT:R-XTR-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Xenopus tropicalis)
RHEA:16149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide
RHEA:16149	skos:prefLabel	"nicotinamide phosphoribosyltransferase"
RHEA:16149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nicotinamide phosphoribosyltransferase"
RHEA:16149	skos:altLabel	"NMN pyrophosphorylase"
RHEA:16149	skos:altLabel	"NMN diphosphorylase"
RHEA:30234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine <=> (2E,6E)-farnesal + H2O2 + L-cysteine
RHEA:29343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate(in) + succinate(out) = L-aspartate(out) + succinate(in)
REACT:R-RNO-9606151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)
RHEA:38921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + H(+) + sphing-4-enine 1-phosphate => H2O + sphing-4-enine-phosphocholine
RHEA:37818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate
RHEA:15286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate
RHEA:57376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:57376	skos:altLabel	"CYP82Y1"
RHEA:57376	skos:prefLabel	"(S)-N-methylcanadine 1-hydroxylase"
RHEA:57376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-N-methylcanadine 1-hydroxylase"
REACT:R-DRE-200681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Danio rerio)
RHEA:64656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapaldehyde + CoA + NADP(+) = (E)-sinapoyl-CoA + H(+) + NADPH
RHEA:32177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose
RHEA:62810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-HSA-2029268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of PLCG (Homo sapiens)
REACT:R-DRE-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Danio rerio)
REACT:R-RNO-170844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 is cleaved by FURIN (Rattus norvegicus)
REACT:R-SPO-9638125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G1P to G6P (Schizosaccharomyces pombe)
RHEA:28450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(D-psicosyl)-L-lysine(in) = N(6)-(D-psicosyl)-L-lysine(out)
REACT:R-MMU-2169046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of TGF-beta receptor complex (Mus musculus)
RHEA:70980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + n H(+)(in) => 4-aminobutanoate(in) + n H(+)(out)
GO:0045145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0045145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ssDNA-specific 5'-3' exodeoxyribonuclease activity
GO:0045145	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
REACT:R-CFA-191322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to DMAPP (Canis familiaris)
REACT:R-DRE-376200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A10-mediated uptake of small neutral amino acids (Danio rerio)
GO:0050345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tartrate epoxydase activity
GO:0050345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-epoxysuccinate hydrolase activity
GO:0050345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-epoxysuccinate hydratase activity
GO:0050345	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans-2,3-epoxysuccinate hydrolase activity
GO:0047154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl-CoA carboxyltransferase activity
GO:0047154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity
GO:0047154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonyl-CoA carboxytransferase activity
GO:0047154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmalonyl-CoA transcarboxylase activity
GO:0047154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxalacetic transcarboxylase activity
GO:0047154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity
GO:0047154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity
GO:0047154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylmalonyl coenzyme A carboxyltransferase activity
GO:0047154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate
GO:0047154	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcarboxylase activity
REACT:R-CEL-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Caenorhabditis elegans)
REACT:R-BTA-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Bos taurus)
GO:1990189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-serine-alpha-N-acetyltransferase activity
RHEA:46324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxochol-4-en-22-oyl-CoA + A = 3-oxochola-4,17-dien-22-oyl-CoA + AH2
REACT:R-SSC-2203479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB2 (FEEL-2) binds ligands (Sus scrofa)
REACT:R-CEL-947535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclisation of GTP to precursor Z (Caenorhabditis elegans)
RHEA:55622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carotenoid beta-end derivative => a carotenoid psi-end group
RHEA:51717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)
REACT:R-RNO-5684006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KPNA2 translocates NBN to the nucleus (Rattus norvegicus)
RHEA:33837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + hexacosanoate => H2O + N-hexacosanoyl-(4R)-hydroxysphinganine
REACT:R-MMU-429094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Mus musculus)
REACT:R-BTA-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)
RHEA:41627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfinopropanoyl-CoA + H2O <=> H(+) + propanoyl-CoA + sulfite
GO:0004633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity
GO:0004633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PPC-decarboxylase activity
GO:0004633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity
GO:0004633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphopantothenoylcysteine decarboxylase activity
GO:0004633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-phosphopantothenoyl-L-cysteine decarboxylase activity
GO:0004633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-phosphopantotheoylcysteine decarboxylase activity
GO:0004633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)
REACT:R-GGA-2029456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 and CDC42 activate PAK1 (Gallus gallus)
REACT:R-GGA-8851011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 polyubiquitinates PTEN (Gallus gallus)
GO:0019182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histamine-gated chloride channel activity
REACT:R-HSA-5626953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds DENN/MADD (Homo sapiens)
REACT:R-DRE-3827958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E-cadherin degradation by MMP9, KLK7 (Danio rerio)
REACT:R-MMU-1028821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Phospho IRF3 or phospho IRF7 (Mus musculus)
RHEA:49317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-glutamate dehydrogenase
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD:glutamate oxidoreductase activity
GO:0004352	skos:prefLabel	"glutamate dehydrogenase"
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked glutamate dehydrogenase activity
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate dehydrogenase (NAD+) activity
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamic dehydrogenase activity
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-linked glutamate dehydrogenase activity
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-specific glutamic dehydrogenase activity
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-specific glutamate dehydrogenase activity
GO:0004352	skos:altLabel	"glutamic dehydrogenase"
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate dehydrogenase (NAD)
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent glutamate dehydrogenase activity
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-glutamate dehydrogenase activity
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:NAD+ oxidoreductase (deaminating)
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glutamic acid dehydrogenase
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate oxidoreductase activity
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-linked glutamic dehydrogenase activity
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD-dependent glutamic dehydrogenase activity
GO:0004352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate dehydrogenase"
REACT:R-DRE-187948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Danio rerio)
REACT:R-DRE-205008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF binds to p62 (Sequestosome) (Danio rerio)
REACT:R-DDI-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Dictyostelium discoideum)
RHEA:28168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-nitrosalicylate + NH4(+) => 5-nitroanthranilate + H(+) + H2O
RHEA:72870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-cAAG + H2O <=> A[3'-5']pG[3'-5']pAp[3'] + H(+)
RHEA:23497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxypentanoate + acetyl-CoA => 5-hydroxy-pentanoyl-CoA + acetate
REACT:R-CFA-2160892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Canis familiaris)
REACT:R-DME-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Drosophila melanogaster)
REACT:R-HSA-199206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Homo sapiens)
REACT:R-MMU-4647593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP400 binds CDKN1A promoter (Mus musculus)
REACT:R-MMU-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)
RHEA:64838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + phenethyl acetate => 2-phenylethanol + acetyl-CoA
GO:0034583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21U-RNA binding
REACT:R-DME-5671707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Drosophila melanogaster)
REACT:R-DRE-1483229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI:PITPNB is transported from the ER membrane to the Golgi membrane (Danio rerio)
GO:0044018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H3-K36 specific)
GO:0044018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H3-K36 specific)
GO:0044018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K36 acetyltransferase activity
GO:0044018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K36 acetyltransferase activity
GO:0044018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H3-K36 specific)
REACT:R-DRE-158747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Danio rerio)
REACT:R-RNO-5685604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLAMF6 binds SLAMF6 (Rattus norvegicus)
GO:0043992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H3-K9 specific)
GO:0043992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 acetyltransferase activity
GO:0043992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K9 acetyltransferase activity
GO:0043992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H3-K9 specific)
GO:0043992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H3-K9 specific)
REACT:R-DME-8854182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D17 binds OPTN:RAB8A (Drosophila melanogaster)
RHEA:66855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
GO:0106105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-tRNA(Thr) deacylase
GO:0106105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ala-tRNA(Thr) hydrolase activity
REACT:R-BTA-192331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)
REACT:R-DRE-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Danio rerio)
REACT:R-CEL-8848611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated PXN recruits the CRK complex (Caenorhabditis elegans)
GO:0140794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone arginine deiminase activity
GO:0140794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone-arginine deiminase activity
GO:0140794	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	histone citrullination
REACT:R-SSC-9689680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG dimer binds IFNG inhibitors (Sus scrofa)
RHEA:62471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + ATP + H(+) <=> 3,4-dihydroxybenzoyl-5'-AMP + diphosphate
RHEA:35691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-versicolorone + NADP(+) = 1'-hydroxyversicolorone + H(+) + NADPH
REACT:R-DRE-428205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O => stearate + sphingosine [Golgi] (Danio rerio)
REACT:R-SSC-5654426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
REACT:R-RNO-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Rattus norvegicus)
REACT:R-BTA-177925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 binds to the phosphorylated EGF receptor:ligand complex (Bos taurus)
REACT:R-GGA-6806831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5Rs reduce MetHb to HbA (Gallus gallus)
REACT:R-XTR-382061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular processing of novel PDGFs (Xenopus tropicalis)
REACT:R-CFA-174660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Canis familiaris)
REACT:R-RNO-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Rattus norvegicus)
REACT:R-RNO-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Rattus norvegicus)
REACT:R-SSC-9734475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds fibrates (Sus scrofa)
RHEA:20530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisic aldehyde + H2O + O2 => 2-cis-(+)-abscisate + H(+) + H2O2
REACT:R-XTR-5693148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCKDK phosphorylates BCKDH (Xenopus tropicalis)
REACT:R-GGA-1168633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB translocates from the cytosol to the nucleus (Gallus gallus)
RHEA:32373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate => all-trans-violaxanthin + 2 L-ascorbate
REACT:R-DRE-6806966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Danio rerio)
REACT:R-GGA-4086088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO1 (Gallus gallus)
RHEA:15481	skos:altLabel	"threonine aldolase"
RHEA:15481	skos:altLabel	"serine hydroxymethyltransferase"
RHEA:15481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine hydroxymethyltransferase"
RHEA:15481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
RHEA:15481	skos:altLabel	"serine hydroxymethylase"
RHEA:15481	skos:altLabel	"serine aldolase"
RHEA:15481	skos:prefLabel	"glycine hydroxymethyltransferase"
REACT:R-XTR-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Xenopus tropicalis)
RHEA:52091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
RHEA:32593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+) => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O
REACT:R-BTA-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Bos taurus)
GO:0047538	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-carboxyarabinitol 1-phosphatase activity
GO:0047538	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity
GO:0047538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-D-arabinitol-1-phosphatase activity
GO:0047538	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity
REACT:R-MMU-452122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Mus musculus)
REACT:R-RNO-964773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OXGR1 binds 2OG (Rattus norvegicus)
RHEA:16877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfino-L-alanine + H(+) = CO2 + hypotaurine
RHEA:51361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-L-leucine => (9Z)-octadecenoate + L-leucine
RHEA:66882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate
RHEA:45695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(octanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(octanoyl)-sphing-4-enine-1-phosphate(out)
REACT:R-CFA-9647631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDMD (1-275) binds PIPs (Canis familiaris)
REACT:R-SSC-73596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCMP + H2O => dUMP + NH4+ (Sus scrofa)
REACT:R-MMU-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Mus musculus)
REACT:R-DME-5339535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLTPD1 transports C1P from plasma membrane to Golgi membrane (Drosophila melanogaster)
REACT:R-RNO-77309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Rattus norvegicus)
REACT:R-SPO-9673054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PM20D1 hydrolyzes oleoyl-phe (Schizosaccharomyces pombe)
REACT:R-CEL-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Caenorhabditis elegans)
REACT:R-DME-75883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHRS7B reduces GO3P to HXDG3P (Drosophila melanogaster)
REACT:R-DRE-173512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Danio rerio)
REACT:R-RNO-373061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR3, 4 and 5 bind CCL5 ligand (Rattus norvegicus)
RHEA:50889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphingoid base 1-phosphate + H2O => an N-acyl-sphingoid base + phosphate
REACT:R-BTA-77609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of APOBEC-1 to form editosome (Bos taurus)
RHEA:42478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate => 2,2',3-trihydroxydiphenyl ether + H(+) + O2
REACT:R-HSA-8948143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Homo sapiens)
REACT:R-CEL-8851899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Caenorhabditis elegans)
GO:0061664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E3
GO:0061664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pup ligase activity
RHEA:39165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-CoA + NADP(+) => 3-oxohexadecanoyl-CoA + H(+) + NADPH
REACT:R-CFA-1169405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of protein phosphatase 1 beta (PP2CB) (Canis familiaris)
REACT:R-MMU-2530453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vitronectin (VTN) binds to C5b:C6:C7 (Mus musculus)
REACT:R-DME-202354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)
REACT:R-HSA-5654641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
REACT:R-CEL-5691006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Caenorhabditis elegans)
RHEA:24300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH2
RHEA:35673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'S)-averufin + H2O => (S)-5'-oxoaverantin + H(+)
RHEA:15876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)
GO:0052733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinate:NADP 3-oxidoreductase activity
GO:0052733	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinate:NADP(+) 3-oxidoreductase activity
GO:0052733	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	quinic dehydrogenase activity
GO:0052733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quinate 3-dehydrogenase (NADP+) activity
REACT:R-HSA-9769165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds PLK2 gene promoter (Homo sapiens)
RHEA:72568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(in) + propanoate(out) => dehydroepiandrosterone 3-sulfate(out) + propanoate(in)
RHEA:21219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribose 5-phosphate <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)
RHEA:26495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + L-tryptophan + O2 => 7-chloro-L-tryptophan + FAD + 2 H2O
GO:0043917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose 1,5-bisphosphate isomerase activity
GO:0043917	skos:prefLabel	"ribose-1,5-bisphosphate isomerase"
GO:0043917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribose-1,5-bisphosphate isomerase"
GO:0043917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribose-1,5-bisphosphate isomerase activity
GO:0043917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate
GO:0043917	skos:altLabel	"ribulose 1,5-bisphosphate synthase"
GO:0043917	skos:altLabel	"RuBP synthase"
REACT:R-GGA-5683888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMCD1 binds GATA6, sequestering it (Gallus gallus)
REACT:R-HSA-1675473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B binds JAK2 (Homo sapiens)
RHEA:23015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + S-adenosyl-L-methionine <=> a fatty acid methyl ester + S-adenosyl-L-homocysteine
REACT:R-DME-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Drosophila melanogaster)
RHEA:50143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O
RHEA:12466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP => myo-inositol + UDP-alpha-D-galactose
RHEA:16640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP
RHEA:64911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + 2 H2O <=> CMP + 2 H(+) + 2 phosphate
REACT:R-CEL-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Caenorhabditis elegans)
REACT:R-BTA-917839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-Transferrin dissociates from the receptor complex (Bos taurus)
REACT:R-HSA-203797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
RHEA:54292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate
RHEA:33465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydroepisterol + 2 H2O + NADP(+) => episterol + H(+) + NADPH + O2
GO:0047313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic-amino-acid-glyoxylate transaminase activity
GO:0047313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aromatic-amino-acid--glyoxylate aminotransferase activity
GO:0047313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aromatic-amino-acid:glyoxylate aminotransferase activity
GO:0047313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aromatic-amino-acid-glyoxylate aminotransferase activity
REACT:R-HSA-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Homo sapiens)
REACT:R-HSA-375395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5a receptor binds C5a anaphylatoxin (Homo sapiens)
REACT:R-CFA-6799722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53I3 oxidoreductase generates unstable semiquinones (Canis familiaris)
RHEA:59422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H2O2 + NH4(+) => H2O + methylamine + O2
REACT:R-XTR-8847887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB33B:GTP binds RIC1:RGP1 (Xenopus tropicalis)
REACT:R-GGA-72139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the active Spliceosomal C complex (Gallus gallus)
GO:0015224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biopterin transmembrane transporter activity
GO:0015224	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biopterin transporter activity
RHEA:17828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glucose <=> ADP + D-glucose 6-phosphate + H(+)
REACT:R-MMU-9714691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds ER effectors (Mus musculus)
REACT:R-SSC-5696960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP49 deubiquitinates H2B (Sus scrofa)
RHEA:49971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 methanethiol + NAD(+) => dimethyl disulfide + H(+) + NADH
REACT:R-CFA-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Canis familiaris)
RHEA:11167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
GO:0004748	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity
GO:0004748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0004748	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity
RHEA:28613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + XTP <=> diphosphate + H(+) + XMP
REACT:R-CFA-5577050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Canis familiaris)
REACT:R-DDI-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Dictyostelium discoideum)
RHEA:20160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] <=> an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)
REACT:R-XTR-5691131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANDI binds CUL1 (Xenopus tropicalis)
REACT:R-GGA-5676966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Gallus gallus)
REACT:R-SSC-2130640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of clathrin coated vesicle by Ii (Sus scrofa)
REACT:R-HSA-8876240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds InlB-activated MET (Homo sapiens)
RHEA:59910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexanoate + NADPH => H2O + hexanal + NADP(+)
RHEA:52726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate
REACT:R-XTR-9657608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Single mechanism MAPK inhibitors bind phosphorylated MAPK (Xenopus tropicalis)
REACT:R-SSC-4085217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Sus scrofa)
GO:0047126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N5-(carboxyethyl)ornithine synthase activity
GO:0047126	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)
GO:0047126	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)
REACT:R-BTA-8932243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Bos taurus)
RHEA:36245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + trans-coumaryl acetate => acetate + NADP(+) + trans-anol
RHEA:37899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase"
RHEA:37899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate
RHEA:37899	skos:prefLabel	"tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase"
RHEA:60195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate
RHEA:33359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:65536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3,7-trimethylurate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theacrine
RHEA:58896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybutyrate--CoA ligase (ADP-forming)"
RHEA:58896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + ADP + phosphate
RHEA:58896	skos:prefLabel	"4-hydroxybutyrate--CoA ligase (ADP-forming)"
REACT:R-HSA-109807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)
REACT:R-SCE-8940388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPLD1 hydrolyses GPI-anchors from proteins (Saccharomyces cerevisiae)
RHEA:57181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + methylglyoxal => N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]
REACT:R-XTR-5685319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex formation (Xenopus tropicalis)
RHEA:45761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-beta-L-daunosamine + epsilon-rhodomycinone => dTDP + H(+) + rhodomycin D
REACT:R-DRE-9612219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds to SRC (Danio rerio)
RHEA:59135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP <=> AMP + diphosphate + H(+) + staphyloferrin B
RHEA:33937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADH + 2 O2
RHEA:33547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lanosteryl hexadecanoate = H(+) + hexadecanoate + lanosterol
RHEA:69000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine = 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine
RHEA:69000	skos:prefLabel	"3-amino-4-hydroxybenzoate 4-O-methyltransferase"
RHEA:69000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-amino-4-hydroxybenzoate 4-O-methyltransferase"
RHEA:35569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + ethanolamine => H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine
REACT:R-HSA-593672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin-X binds DCC/Neogenin (Homo sapiens)
RHEA:20420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coelenterazine + O2 <=> CO2 + coelenteramide + hnu
RHEA:31266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	but-3-ynal + H(+) + pyrroloquinoline quinol <=> but-3-yn-1-ol + pyrroloquinoline quinone
REACT:R-SSC-5683774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T68-CHEK2 dimerizes (Sus scrofa)
RHEA:51015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacyl-sn-glycero-3-phosphocholine + H2O <=> a monoacylglycerol + H(+) + phosphocholine
REACT:R-SSC-4641129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is ubiquitinated by SMURF2 (Sus scrofa)
RHEA:45998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + a quinol + NH4(+) => a D-alpha-amino acid + a quinone + H2O
REACT:R-HSA-5653936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Ragulator complex (Homo sapiens)
REACT:R-MMU-6799197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Mus musculus)
RHEA:32555	skos:prefLabel	"(+)-alpha-terpineol synthase"
RHEA:32555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(+)-alpha-terpineol synthase"
RHEA:32555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + H2O = (R)-alpha-terpineol + diphosphate
REACT:R-SSC-3371591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of cytosolic HSF1 (Sus scrofa)
RHEA:11403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-6-deoxy-alpha-D-altrose + sordaricin <=> 4'-O-demethylsordarin + GDP + H(+)
GO:0009815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate oxidase activity
GO:0009815	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ethene-forming enzyme
GO:0009815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)
GO:0009815	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ethylene-forming enzyme
GO:0009815	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminocyclopropanecarboxylate oxidase activity
GO:0009815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACC oxidase activity
RHEA:57008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,5'-dehydrodivanillate + H(+) + NADH + O2 = 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)
REACT:R-BTA-4090408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate ESR1 with SUMO1 (Bos taurus)
GO:0062239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heterochromatin-nuclear membrane anchor activity
GO:0062239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heterochromatin-nuclear membrane tether activity
GO:0062239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane-heterochromatin tether activity
GO:0062239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear membrane-heterochromatin anchor activity
REACT:R-DDI-71217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Dictyostelium discoideum)
RHEA:57258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP
REACT:R-DDI-6810594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Dictyostelium discoideum)
REACT:R-HSA-8939963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated AKT phosphorylates RUNX2 (Homo sapiens)
REACT:R-CFA-9013110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC binds effectors at the plasma membrane (Canis familiaris)
RHEA:14753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:50458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D3 => prostaglandin H3
RHEA:60125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-sodorifen diphosphate => diphosphate + sodorifen
EC:2.4.1.253	skos:prefLabel	"baicalein 7-O-glucuronosyltransferase"
EC:2.4.1.253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"baicalein 7-O-glucuronosyltransferase"
EC:2.4.1.253	skos:altLabel	"UBGAT"
REACT:R-SSC-199219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Sus scrofa)
RHEA:14412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteamine + O2 <=> H(+) + hypotaurine
REACT:R-DME-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)
REACT:R-CFA-8964280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active Gq binds BTK (Canis familiaris)
RHEA:37585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-2-oxohexanoate + H2O2 + NH4(+) => D-lysine + H2O + O2
REACT:R-RNO-2534378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hv1 Mediated H+ Permeability (Rattus norvegicus)
REACT:R-DRE-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Danio rerio)
REACT:R-GGA-5654571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FRS3 (Gallus gallus)
RHEA:24318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate
REACT:R-CFA-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Canis familiaris)
REACT:R-DRE-446277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhCG mediates ammonium efflux out of kidney collecting duct cells (Danio rerio)
REACT:R-MMU-5684267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)
REACT:R-RNO-111437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the 3'-end of the Histone Pre-mRNA (Rattus norvegicus)
RHEA:20986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine 1-phosphate + choline + H(+) => a sphingomyelin + H2O
REACT:R-DME-209321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT92E dissociates from HOP and DOME and dimerises (Drosophila melanogaster)
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphohistidinoprotein-hexose phosphotransferase activity
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate-sugar phosphotransferase enzyme II
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-Np-phosphohistidine-sugar phosphotransferase activity
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEP-dependent phosphotransferase enzyme II
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTS permease activity
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphotransfer-driven group translocator
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoprotein factor-hexose phosophotransferase activity
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTS transporter
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enzyme II of the phosphotransferase system
GO:0008982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEP--sugar phosphotransferase enzyme II activity
EC:1.5.98.-	skos:prefLabel	"With other, known, acceptors"
EC:1.5.98.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known, acceptors"
REACT:R-HSA-1980041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 binds DLL4 (Homo sapiens)
REACT:R-SCE-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Saccharomyces cerevisiae)
REACT:R-DME-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Drosophila melanogaster)
REACT:R-DRE-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Danio rerio)
REACT:R-CEL-156678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc25C (Caenorhabditis elegans)
REACT:R-CEL-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Caenorhabditis elegans)
RHEA:49529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethylene terephthalate)(n) + H2O => (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)
REACT:R-MMU-2161899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Mus musculus)
RHEA:40871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + FAD + H(+) = (2E,9Z)-octadecadienoyl-CoA + FADH2
RHEA:28813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dioxo-L-gulonate(out) + Na(+)(out) => 2,3-dioxo-L-gulonate(in) + Na(+)(in)
RHEA:23511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O <=> (7R)-7-aminocephalosporanate + glutarate
GO:0120170	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IFT B complex binding
GO:0120170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intraciliary transport particle B binding
GO:0120170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intraciliary transport complex B binding
GO:0120170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intraflagellar transport complex B binding
GO:0120170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	intraflagellar transport particle B binding
REACT:R-CEL-3858489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ppDVL binds DAAM1 (Caenorhabditis elegans)
GO:0042806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fucose binding
REACT:R-GGA-517846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR2-1 :TLR1-1 binds to triacyl lipopeptide (Gallus gallus)
REACT:R-BTA-6788999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HV1-mediated H+ transfer (Bos taurus)
GO:0047259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucomannan 4-beta-mannosyltransferase"
GO:0047259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucomannan 4-b-mannosyltransferase activity
GO:0047259	skos:altLabel	"glucomannan-synthase"
GO:0047259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucomannan 4-beta-mannosyltransferase activity
GO:0047259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucomannan-synthase activity
GO:0047259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity
GO:0047259	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-man-beta-mannan mannosyltransferase activity
GO:0047259	skos:prefLabel	"glucomannan 4-beta-mannosyltransferase"
REACT:R-CFA-213406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from LAT (Canis familiaris)
REACT:R-HSA-1676164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Homo sapiens)
REACT:R-SCE-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Saccharomyces cerevisiae)
RHEA:23999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-phosphate + diphosphate + H(+)
REACT:R-BTA-8963734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Bos taurus)
REACT:R-DME-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Drosophila melanogaster)
RHEA:19011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + H(+) + pyruvate => a 3-acylpyruvate + H2O
RHEA:57922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-asparaginyl-tRNA(Asn) + phosphate => 4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+)
RHEA:42952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-8864690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A,(TFAP2B) homodimers bind the KIT gene promoter (Homo sapiens)
GO:0102203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	brassicasterol glucosyltransferase activity
REACT:R-HSA-110171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences (Homo sapiens)
REACT:R-DRE-3249390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Danio rerio)
REACT:R-DDI-192335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Dictyostelium discoideum)
RHEA:31891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-1-phenyl-1-propanone + NADP(+) = 1-phenyl-1,2-propanedione + H(+) + NADPH
REACT:R-XTR-5654575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS2 (Xenopus tropicalis)
RHEA:49709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nocardicin G + S-adenosyl-L-methionine => H(+) + isonocardicin C + S-methyl-5'-thioadenosine
REACT:R-BTA-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Bos taurus)
RHEA:58385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octan-1-ol => H(+) + NADPH + octanal
RHEA:20156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-arabinose <=> ADP + beta-L-arabinose 1-phosphate + H(+)
REACT:R-SPO-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Schizosaccharomyces pombe)
REACT:R-DRE-375395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5a receptor binds C5a anaphylatoxin (Danio rerio)
RHEA:64362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2
RHEA:31396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-4,4'-diapophytoene + FAD + H(+) => all-trans-4,4'-diapophytofluene + FADH2
REACT:R-SSC-909552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 at Ser727 (Sus scrofa)
REACT:R-XTR-5624127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome target cargo to the primary cilium (Xenopus tropicalis)
REACT:R-BTA-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Bos taurus)
REACT:R-SSC-8875871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A11 transports SO4(2-) from extracellular region to cytosol (Sus scrofa)
RHEA:48324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD1b + GDP-beta-L-fucose = ganglioside Fuc-GD1b + GDP + H(+)
RHEA:17623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalyl-CoA + acetate => acetyl-CoA + citramalate
GO:0016603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminyl-transfer ribonucleate cyclotransferase activity
GO:0016603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaminyl-peptide cyclotransferase activity
GO:0016603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)
GO:0016603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutaminyl cyclase activity
GO:0016603	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glutaminyl-tRNA cyclotransferase activity
REACT:R-XTR-977375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR1 binds C3bBb/C4bC2a (Xenopus tropicalis)
REACT:R-DRE-83660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-anchored TNF-α binds TNFR1 (Danio rerio)
REACT:R-RNO-9634169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 and NDC1 bind the Nup93 complex (Rattus norvegicus)
REACT:R-BTA-9035484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CysS248-MPST:TXN2 dissociates (Bos taurus)
REACT:R-DME-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Drosophila melanogaster)
REACT:R-CFA-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)
REACT:R-CEL-9610166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,Y MAPK dimers translocate to nucleus (Caenorhabditis elegans)
REACT:R-XTR-70361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Xenopus tropicalis)
GO:0140815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + NAD(+) = H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide
GO:0140815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-protein-histidine ADP-ribosyltransferase activity
RHEA:54302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate
GO:0102321	skos:prefLabel	"2-hydroxybiphenyl 3-monooxygenase"
GO:0102321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2,2'-diol + H(+) + NADH + O2 = biphenyl-2,2',3-triol + H2O + NAD(+)
GO:0102321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biphenyl-2-ol + H(+) + NADH + O2 = biphenyl-2,3-diol + H2O + NAD(+)
GO:0102321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2'-hydroxybiphenyl monooxygenase activity
GO:0102321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxybiphenyl 3-monooxygenase"
RHEA:15738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopentanone + H(+) + NADPH + O2 => 5-valerolactone + H2O + NADP(+)
REACT:R-CFA-6786012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Canis familiaris)
RHEA:13248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate <=> glyoxylate + succinate
RHEA:61085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + 2-oxoglutarate + O2 => (2R,3R)-dihydrokaempferol + CO2 + succinate
RHEA:35327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + H(+) + malonyl-CoA = 3-oxodocosanoyl-CoA + CO2 + CoA
REACT:R-SSC-6784765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimerizes (Sus scrofa)
REACT:R-HSA-5686074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Homo sapiens)
REACT:R-HSA-388863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)
REACT:R-SPO-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Schizosaccharomyces pombe)
REACT:R-BTA-5333678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPNEs bind PL (Bos taurus)
REACT:R-MMU-8955010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRTOMT transfers Met to DA, forming 3MT (Mus musculus)
REACT:R-SSC-203774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Csk with PAG (Sus scrofa)
REACT:R-SSC-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Sus scrofa)
RHEA:18384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone + phosphoenolpyruvate <=> dihydroxyacetone phosphate + pyruvate
REACT:R-MMU-9013435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD auto-activates (Mus musculus)
RHEA:27843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-carbazole + H(+) + NADPH + O2 => 2'-aminobiphenyl-2,3-diol + NADP(+)
REACT:R-MMU-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Mus musculus)
REACT:R-HSA-2730862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of LYN kinase (Homo sapiens)
REACT:R-SSC-994140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Sus scrofa)
GO:0016997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-sialidase activity
REACT:R-MMU-174057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of APC/C-associated Cdh1 (Mus musculus)
RHEA:39102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodecanedioyl-CoA + CoA <=> acetyl-CoA + octanedioyl-CoA
RHEA:32871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acylglycerol + H2O = a carboxylate + glycerol + H(+)
RHEA:65744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + decyl sulfate + O2 = CO2 + decanal + H(+) + succinate + sulfate
RHEA:64332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + nicotinate = AMP + diphosphate + nicotinyl-CoA
REACT:R-DME-6809309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR6 binds MTMR9 (Drosophila melanogaster)
RHEA:65788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-RNO-6809320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Rattus norvegicus)
REACT:R-DME-3134954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX9 binds DNA (Drosophila melanogaster)
REACT:R-GGA-428749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TP receptor binds G-proten Gq (Gallus gallus)
RHEA:25881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-dopa + O2 => 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)
REACT:R-GGA-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Gallus gallus)
REACT:R-RNO-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)
RHEA:37923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 = (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate
REACT:R-HSA-8865182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7A hydrolyses K11diUb (Homo sapiens)
RHEA:33415	skos:prefLabel	"6-oxocamphor hydrolase"
RHEA:33415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bornane-2,6-dione + H2O = [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)
RHEA:33415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-oxocamphor hydrolase"
REACT:R-GGA-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Gallus gallus)
RHEA:52984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] = 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]
REACT:R-HSA-2134506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)
GO:0015436	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	capsular-polysaccharide ABC transporter
GO:0015436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent capsular-polysaccharide transporter activity
GO:0015436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled capsular-polysaccharide transporter activity
GO:0015436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	capsular-polysaccharide-transporting ATPase activity
GO:0015436	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP phosphohydrolase (capsular-polysaccharide-exporting)
GO:0015436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type capsular-polysaccharide transporter activity
REACT:R-SPO-70997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Schizosaccharomyces pombe)
RHEA:57755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)
REACT:R-DRE-419841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Light stimulates opsin receptors (Danio rerio)
RHEA:24777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + pheophorbide a => C-13(2)-carboxypyropheophorbide a + methanol
REACT:R-HSA-205262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Direct recruitment of PI3K to p-KIT (Homo sapiens)
RHEA:36491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA
RHEA:19857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 16alpha-hydroxysteroid + NADP(+) = a 16-oxosteroid + H(+) + NADPH
REACT:R-SPO-71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanol + NAD+ => acetaldehyde + NADH + H+ (Schizosaccharomyces pombe)
REACT:R-HSA-1369115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 is phosphorylated (Homo sapiens)
RHEA:56680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-dihydromenaquinone-9 omega-hydroxylase"
RHEA:56680	skos:altLabel	"CYP128"
RHEA:56680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:56680	skos:prefLabel	"beta-dihydromenaquinone-9 omega-hydroxylase"
REACT:R-XTR-199576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR3DL2 interacting with HLA-A3 (Xenopus tropicalis)
RHEA:37366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O
RHEA:17235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fuculose => L-fucose
REACT:R-DDI-8863723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COP9 and TOR1 deneddylate STON2 (Dictyostelium discoideum)
RHEA:52341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] => AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]
REACT:R-HSA-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Homo sapiens)
REACT:R-SPO-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Schizosaccharomyces pombe)
REACT:R-DDI-5694485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD3 hydrolyses LPC(14:0) to 1AGPC (Dictyostelium discoideum)
RHEA:30874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose + ATP <=> 2-deoxy-D-ribose 5-phosphate + ADP + H(+)
REACT:R-CFA-110349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of UNG glycosylase by APEX1 at the AP site (Canis familiaris)
REACT:R-SSC-1482685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)
RHEA:12598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + phosphinothricin => CoA + H(+) + N-acetylphosphinothricin
RHEA:31349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisate + beta-D-glucose + H(+) => (+)-abscisic acid D-glucopyranosyl ester + H2O
REACT:R-XTR-2396002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Xenopus tropicalis)
REACT:R-SCE-70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + acetyl CoA => N-acetyl glutamate + CoA (Saccharomyces cerevisiae)
REACT:R-HSA-71660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Homo sapiens)
REACT:R-XTR-176631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Xenopus tropicalis)
GO:0050502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-zeatin O-b-D-glucosyltransferase activity
GO:0050502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity
GO:0050502	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity
GO:0050502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-zeatin O-beta-D-glucosyltransferase activity
RHEA:37860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA => 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-XTR-9645501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Xenopus tropicalis)
RHEA:68071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:42197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CEL-435366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT1 mediates the efflux of zinc from the cell (Caenorhabditis elegans)
RHEA:70153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-5656459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective KHK does not phosphorylate beta-D-fructose (Homo sapiens)
REACT:R-XTR-1980125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH binds DTX (Xenopus tropicalis)
RHEA:19562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADPH + O2 => H2O + NADP(+) + testololactone
REACT:R-SSC-3322434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP dissociates from ub-TLE (Sus scrofa)
REACT:R-BTA-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Bos taurus)
RHEA:58195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin <=> dihydrobisanhydrobacterioruberin + diphosphate
RHEA:18293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oxalate--CoA ligase"
RHEA:18293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + oxalate = AMP + diphosphate + oxalyl-CoA
RHEA:18293	skos:altLabel	"oxalyl-CoA synthetase"
RHEA:18293	skos:prefLabel	"oxalate--CoA ligase"
REACT:R-RNO-8982020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Rattus norvegicus)
RHEA:49833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty aldehyde + H2O + NAD(+) => a fatty acid + 2 H(+) + NADH
RHEA:65297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:25198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + phosphate
GO:0018765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity
REACT:R-DDI-8867370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Dictyostelium discoideum)
REACT:R-MMU-383313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like Peptide 1 is secreted from intestinal L cells (Mus musculus)
RHEA:51119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(6) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine
REACT:R-SSC-1667005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Sus scrofa)
REACT:R-HSA-9613264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Homo sapiens)
RHEA:39641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA
RHEA:35149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in)
REACT:R-CFA-203565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)
REACT:R-DDI-265295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prostaglandin E synthase isomerizes PGH2 to PGE2 (Dictyostelium discoideum)
REACT:R-BTA-70596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 dimer deaminates L-Asp (Bos taurus)
REACT:R-RNO-2046265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALTs transfer Gal to the keratan chain (Rattus norvegicus)
RHEA:15101	skos:altLabel	"meso-2,6-diaminoheptanedioate carboxy-lyase"
RHEA:15101	skos:prefLabel	"diaminopimelate decarboxylase"
RHEA:15101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine
RHEA:15101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diaminopimelate decarboxylase"
RHEA:15101	skos:altLabel	"DAP decarboxylase"
GO:0050207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylacylglycerophosphoethanolamine desaturase activity
GO:0050207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasmenylethanolamine desaturase activity
GO:0050207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkylacylglycero-phosphorylethanolamine dehydrogenase activity
GO:0050207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity
GO:0050207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	plasmanylethanolamine desaturase activity
GO:0050207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity
GO:0050207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dehydrogenase, alkyl-acylglycerophosphorylethanolamine
GO:0050207	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase activity
RHEA:17720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)
EC:2.7.11.11	skos:altLabel	"PKA"
EC:2.7.11.11	skos:altLabel	"protein kinase A"
EC:2.7.11.11	skos:altLabel	"PKA C"
EC:2.7.11.11	skos:prefLabel	"cAMP-dependent protein kinase"
EC:2.7.11.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cAMP-dependent protein kinase"
REACT:R-DME-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Drosophila melanogaster)
RHEA:11522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-menthyl beta-D-glucoside + H(+) + UDP => (-)-menthol + UDP-alpha-D-glucose
REACT:R-DRE-202489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of Bcl10 (Danio rerio)
REACT:R-HSA-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Homo sapiens)
REACT:R-MMU-210430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of L-Glutamate at the synapse (Mus musculus)
RHEA:46669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone + H(+) + NADPH => 5beta-dihydrodeoxycorticosterone + NADP(+)
EC:1.14.13.195	skos:prefLabel	"L-ornithine N(5)-monooxygenase (NADPH)"
EC:1.14.13.195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-ornithine N(5)-monooxygenase (NADPH)"
EC:1.14.13.195	skos:altLabel	"ornithine hydroxylase"
RHEA:72791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin-glucuronoside(out) = bilirubin-glucuronoside(in)
REACT:R-HSA-9728776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 nsp1 binds to RCAN3 (Homo sapiens)
REACT:R-CFA-114544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p115-RhoGEF activation of RHOA (Canis familiaris)
RHEA:39112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH
RHEA:51906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate
REACT:R-DME-5687464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN and RBBP8 resect DNA DSBs in MMEJ (Drosophila melanogaster)
RHEA:29273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H2O + trimethylamine => a menaquinol + H(+) + trimethylamine N-oxide
REACT:R-BTA-5324617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:FKBP4:PTGES3 binds HSF1 trimer (Bos taurus)
REACT:R-HSA-5357927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL oligomerizes  (Homo sapiens)
REACT:R-HSA-9700131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK mutants bind type I TKIs (Homo sapiens)
REACT:R-CFA-2023973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
RHEA:49319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:54861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranial + H(+) + NADPH + O2 => (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)
REACT:R-SSC-216076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Sus scrofa)
RHEA:30597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + FAD + H(+) + H2O => 4-hydroxyphenylacetate + FADH2 + O2
RHEA:47869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-(9Z)-octadecenoylglycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
REACT:R-DRE-71181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarylacetoacetate => fumarate + acetoacetate (Danio rerio)
REACT:R-MMU-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Mus musculus)
REACT:R-DDI-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Dictyostelium discoideum)
RHEA:57144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)
GO:0005169	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	neurotrophin TRKB receptor ligand
GO:0005169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurotrophin TRKB receptor binding
REACT:R-XTR-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Xenopus tropicalis)
RHEA:45755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-decenoyl-CoA <=> (2E)-decenoyl-CoA
REACT:R-MMU-751001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (i) reassociates with G beta:gamma (Mus musculus)
REACT:R-XTR-5692768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK5 phosphorylates KALRN (Xenopus tropicalis)
RHEA:13431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol + diphosphate => 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+)
REACT:R-HSA-5635842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3 phosphorylates GLI (Homo sapiens)
GO:0033803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	F 4'-OMT
GO:0033803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol 4'-O-methyltransferase activity
GO:0033803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity
GO:0033803	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity
RHEA:51878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethylxanthohumol + diphosphate => 2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate
RHEA:48658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:51840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) + tauroallocholate(in)
REACT:R-XTR-975814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Xenopus tropicalis)
RHEA:24971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> H2O + 2 oxidized [adrenodoxin] + secalciferol
REACT:R-CFA-2161613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Canis familiaris)
RHEA:22877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelamide + H2O => (R)-mandelate + NH4(+)
REACT:R-DRE-373087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR6 binds CCL20 ligand (Danio rerio)
RHEA:71627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) + succinate(out) = phosphate(out) + succinate(in)
REACT:R-HSA-9615571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN mRNA translation is inhibited by miR-137 (Homo sapiens)
REACT:R-HSA-167133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Homo sapiens)
REACT:R-BTA-1614591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess cysteine yields lanthionine and H2S (Bos taurus)
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	anthranilic hydroxylase activity
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	anthranilate dioxygenase reductase
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	anthranilate hydroxylase activity
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate dioxygenase activity
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AntB
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AntC
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AntA
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	anthranilic acid hydroxylase activity
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilate 1,2-dioxygenase
GO:0018618	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)
REACT:R-GGA-6787820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds CSF1R (Gallus gallus)
RHEA:36547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sphinganine = CoA + H(+) + N-(octadecanoyl)-sphinganine
RHEA:43304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer = 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)
REACT:R-DRE-5607043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIIIa associates with cell membrane (Danio rerio)
REACT:R-CFA-8944227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXII (Canis familiaris)
RHEA:19776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sn-glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + H(+) + NADPH
RHEA:71320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-cysteine(out) + 2 Na(+)(out) => chloride(in) + L-cysteine(in) + 2 Na(+)(in)
REACT:R-DRE-1604732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP13 (Danio rerio)
EC:3.4.21.62	skos:prefLabel	"subtilisin"
EC:3.4.21.62	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"subtilisin"
REACT:R-HSA-1482884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Homo sapiens)
RHEA:21845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine + phenylacetyl-CoA => CoA + H(+) + N(2)-phenylacetyl-L-glutamine
REACT:R-XTR-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Xenopus tropicalis)
REACT:R-MMU-158311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Mus musculus)
REACT:R-HSA-6787525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58 (Homo sapiens)
RHEA:32962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-isoleucine + NAD(+) <=> (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)
RHEA:57669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:37090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
REACT:R-HSA-8952128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TP53 (Homo sapiens)
REACT:R-HSA-5694418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
RHEA:53242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]
GO:0039632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA packaging ATPase activity
GO:0039632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA translocase activity involved in viral RNA genome packaging
GO:0039632	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	viral RNA packaging activity
REACT:R-DME-5227009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCF1 binds EIF2 (Drosophila melanogaster)
REACT:R-DRE-112033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Danio rerio)
RHEA:63451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + CTP <=> CMP-(2-aminoethyl)phosphonate + diphosphate
REACT:R-RNO-109998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Rattus norvegicus)
REACT:R-GGA-400015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diacylgycerol activates Protein kinase C, alpha type (Gallus gallus)
REACT:R-DDI-4568914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of BLM with SUMO2,3 (Dictyostelium discoideum)
RHEA:10706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-valyl-tRNA(Val) => ATP + L-valine + tRNA(Val)
GO:0016212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenine transaminase (cyclizing)
GO:0016212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine-oxoglutarate transaminase activity
GO:0016212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-kynurenine aminotransferase activity
GO:0016212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine-oxoglutarate aminotransferase activity
GO:0016212	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	kynurenine aminotransferase activity
GO:0016212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-kynurenine:2-oxoglutarate aminotransferase activity
GO:0016212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenine 2-oxoglutarate transaminase activity
GO:0016212	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	kynurenine--oxoglutarate aminotransferase activity
REACT:R-BTA-5357845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is deubiquitinated (Bos taurus)
RHEA:48371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)
GO:0047216	skos:prefLabel	"inositol 3-alpha-galactosyltransferase"
GO:0047216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 1-alpha-galactosyltransferase activity
GO:0047216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-inositol galactosyltransferase activity
GO:0047216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactinol synthase activity
GO:0047216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity
GO:0047216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol 3-alpha-galactosyltransferase activity
GO:0047216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol 3-alpha-galactosyltransferase"
GO:0047216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity
GO:0047216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol + UDP-alpha-D-galactose = alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP
GO:0047216	skos:altLabel	"galactinol synthase"
GO:0047216	skos:altLabel	"inositol 1-alpha-galactosyltransferase"
GO:0047216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-galactose:inositol galactosyltransferase activity
GO:0047216	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity
REACT:R-CFA-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Canis familiaris)
REACT:R-SSC-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Sus scrofa)
REACT:R-DRE-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)
RHEA:22271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin <=> ADP + H(+) + streptomycin 6-phosphate
REACT:R-RNO-6808496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)
REACT:R-HSA-9022734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds FKBP5 gene promoter (Homo sapiens)
RHEA:24618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone + H(+) + NADPH => 17beta-estradiol + NADP(+)
GO:0039552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX58/RIG-I binding
GO:0039552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX58 binding
GO:0039552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIG-I binding
REACT:R-DME-9635743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 binds p-T,Y-MAPK (Drosophila melanogaster)
REACT:R-DDI-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
REACT:R-HSA-1650808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Homo sapiens)
RHEA:25828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 = A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O
RHEA:22959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:60085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADH
REACT:R-RNO-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Rattus norvegicus)
GO:0015624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferric-enterobactin ABC transporter
GO:0015624	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled ferric-enterobactin transmembrane transporter activity
GO:0015624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent ferric-enterobactin transmembrane transporter activity
GO:0015624	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ferric-enterobactin porter activity
GO:0015624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type ferric-enterobactin transporter activity
GO:0015624	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferric-enterobactin-transporting ATPase activity
RHEA:57829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dIMP + H2O => 2-deoxy-D-ribose 5-phosphate + hypoxanthine
REACT:R-MMU-981728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to membrane-associated C3b (Mus musculus)
REACT:R-MMU-2168885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Haptoglobin binds Hemoglobin (Mus musculus)
RHEA:69137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 O2 + spermine => 2 H2O2 + 2 NH4(+) + spermine dialdehyde
RHEA:48909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP
RHEA:72291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dimethylsuccinate(out) + 3 Na(+)(out) = 2,3-dimethylsuccinate(in) + 3 Na(+)(in)
RHEA:30177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9 => 15-cis-phytoene + 2 plastoquinone-9
RHEA:45367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine <=> (11Z)-eicosenoate + (4R)-hydroxysphinganine
RHEA:16898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid + a triacylglycerol => a 3beta-hydroxysteroid ester + a diacylglycerol
REACT:R-HSA-170850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)
REACT:R-RNO-5205652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 recruits Parkin to the outer mitochondrial membrane. (Rattus norvegicus)
RHEA:49125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + protodeoxyviolaceinate => H2O + NADP(+) + protoviolaceinate
RHEA:39658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O
GO:0102499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHG alpha-glucan phosphorylase activity
GO:0102499	skos:altLabel	"polyphosphorylase"
GO:0102499	skos:altLabel	"amylophosphorylase"
GO:0102499	skos:prefLabel	"glycogen phosphorylase"
GO:0102499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
GO:0102499	skos:altLabel	"muscle phosphorylase a and b"
GO:0102499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycogen phosphorylase"
REACT:R-XTR-9728150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 binds gliflozins (Xenopus tropicalis)
REACT:R-RNO-8864036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN12 dephosphorylates PDGFRB at Y1021 (Rattus norvegicus)
REACT:R-HSA-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Homo sapiens)
RHEA:48340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate
RHEA:48340	skos:altLabel	"butyryl-CoA synthetase"
RHEA:48340	skos:altLabel	"acyl-activating enzyme"
RHEA:48340	skos:prefLabel	"medium-chain acyl-CoA ligase"
RHEA:48340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"medium-chain acyl-CoA ligase"
RHEA:48340	skos:altLabel	"fatty acid thiokinase (medium chain)"
REACT:R-SSC-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Sus scrofa)
RHEA:29498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> beta-eudesmol + diphosphate
RHEA:72368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + succinate(in) => estrone 3-sulfate(in) + succinate(out)
REACT:R-HSA-6798174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIK3C3:PIK3R4 phosphorylates PI to PI3P (Homo sapiens)
REACT:R-RNO-8983834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Rattus norvegicus)
GO:0018848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pinocarveol isomerase activity
RHEA:52000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O
RHEA:46682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + H(+) + NAD(+) => 2 Fe(III)-[cytochrome b5] + NADH
REACT:R-HSA-450620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S193-KSRP binds 14-3-3zeta in the nucleus (Homo sapiens)
REACT:R-MMU-5205663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)
RHEA:52009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
RHEA:59569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate + ATP + L-histidine => ADP + H(+) + L-homocarnosine + phosphate
GO:0047357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity
GO:0047357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactosyl phosphotransferase activity
GO:0047357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	galactose-1-phosphotransferase activity
GO:0047357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity
GO:0047357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity
GO:0047357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity
GO:0047357	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity
REACT:R-HSA-975903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Homo sapiens)
REACT:R-RNO-3000433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PML with SUMO3 (Rattus norvegicus)
GO:0008853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exodeoxyribonuclease III activity
GO:0008853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Escherichia coli exonuclease III
GO:0008853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E. coli exonuclease III
GO:0008853	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	E. coli exonuclease III activity
GO:0008853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoribonuclease III
GO:0008853	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exonuclease III activity
REACT:R-HSA-2426450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Laminins:Nidogens binds collagen type IV networks (Homo sapiens)
RHEA:41475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-392835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 sequesters Raf1 to inhibit ERK cascade (Rattus norvegicus)
RHEA:67950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose
RHEA:45783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
REACT:R-HSA-8863012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calpain cleaves p35 to p25 (Homo sapiens)
REACT:R-HSA-6809975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
RHEA:47324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-3-phenylpropanoate + pyruvate = 3-oxo-3-phenylpropanoate + L-alanine
RHEA:47443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) <=> 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH
REACT:R-SSC-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Sus scrofa)
RHEA:55515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:48138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate => ganglioside GM3 + H2O
GO:0005545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol binding
REACT:R-MMU-159005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)
RHEA:17627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-lysine + NADPH + pyruvate => D-lysopine + H2O + NADP(+)
REACT:R-HSA-1169394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of IRF3 (Homo sapiens)
REACT:R-RNO-5626953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds DENN/MADD (Rattus norvegicus)
RHEA:65210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxybutanoate + CoA + H(+) => (3S)-3-hydroxybutanoyl-CoA + H2O
REACT:R-CEL-2327733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN1 binds Collagen types I-V, VII (Caenorhabditis elegans)
RHEA:15616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + precorrin-2 <=> 2 H(+) + NADH + sirohydrochlorin
REACT:R-MMU-6786058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL4R in IL4-bound IL4R1 (Mus musculus)
GO:0034321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alcohol O-octanoyltransferase activity
REACT:R-DRE-196950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTRAP hydrolyzes FMN to RIB (Danio rerio)
REACT:R-HSA-8944255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type VII (Homo sapiens)
REACT:R-SCE-6807053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SC5D desaturates LTHSOL to 7-dehydroCHOL (Saccharomyces cerevisiae)
REACT:R-CEL-390930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-HT2 receptor can bind serotonin (Caenorhabditis elegans)
RHEA:45971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-4-ene-3,17-dione + H(+) + NADH + O2 <=> 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)
REACT:R-HSA-5252041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)
RHEA:34210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-alpha-D-glucosyl-L-rhamnose + phosphate <=> beta-D-glucose 1-phosphate + L-rhamnopyranose
REACT:R-HSA-8956106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)
REACT:R-DME-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Drosophila melanogaster)
RHEA:40537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
RHEA:52851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine <=> 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:11966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholestane-3beta,5,6beta-triol => 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
REACT:R-GGA-416929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PGF2a (Gallus gallus)
GO:0052624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinone methyltransferase activity
GO:0052624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:demethylphylloquinone methyltransferase activity
GO:0052624	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	salicylic acid methyltransferase activity
GO:0052624	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	SA methyltransferase activity
GO:0052624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylphylloquinone methyltransferase activity
GO:0052624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:salicylate carboxyl methyltransferase activity
GO:0052624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phytyl-1,4-naphthoquinone methyltransferase activity
GO:0052624	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	salicylate methyltransferase activity
REACT:R-HSA-174401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)
RHEA:48203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA <=> reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA
RHEA:32581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,5R)-beta-pinene + diphosphate => (2E)-geranyl diphosphate
REACT:R-HSA-9753278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Homo sapiens)
RHEA:69328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate = 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur
REACT:R-SSC-9750546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC4 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)
RHEA:68181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty acyl-CoA + H2O => a short-chain fatty acid + CoA + H(+)
REACT:R-HSA-5693356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEMIP hydrolyses HA (Homo sapiens)
REACT:R-HSA-209823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine is hydroxylated to dopa (Homo sapiens)
REACT:R-HSA-9674095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGFRs bind type II TKI (Homo sapiens)
REACT:R-XTR-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Xenopus tropicalis)
RHEA:30386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (-)-7-epi-alpha-selinene + diphosphate
REACT:R-BTA-5668417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Bos taurus)
GO:0033847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-phosphoserine sulfhydrylase"
GO:0033847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity
GO:0033847	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	O-phosphoserine(thiol)-lyase activity
GO:0033847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogen sulfide + O-phospho-L-serine = L-cysteine + phosphate
GO:0033847	skos:prefLabel	"O-phosphoserine sulfhydrylase"
GO:0033847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-phosphoserine sulfhydrylase activity
GO:0033847	skos:altLabel	"O-phosphoserine(thiol)-lyase"
REACT:R-CFA-5686072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-3Y-SHC1 dissociates from IGF1R (Canis familiaris)
REACT:R-GGA-8956676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TP73 (Gallus gallus)
RHEA:11951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoyl-CoA + H2O <=> 4-hydroxybenzoate + CoA + H(+)
REACT:R-SCE-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Saccharomyces cerevisiae)
REACT:R-MMU-9686922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 binds activated RIPK1:RIPK3 (Mus musculus)
REACT:R-HSA-6789077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrogen peroxide enters the bacterium (Homo sapiens)
RHEA:16666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O => (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate
GO:0102359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daphnetin 4-O-beta-glucosyltransferase activity
REACT:R-XTR-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Xenopus tropicalis)
RHEA:20918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + L-cysteate => L-cysteine + sulfite
REACT:R-CEL-70569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG1] (Caenorhabditis elegans)
RHEA:17178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + octanoyl-CoA => CoA + O-octanoyl-(R)-carnitine
REACT:R-HSA-5432814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR2:TLR1 (Homo sapiens)
RHEA:37402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-DRE-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Danio rerio)
GO:0015556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C4-dicarboxylate transmembrane transporter activity
REACT:R-CFA-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Canis familiaris)
REACT:R-HSA-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Homo sapiens)
REACT:R-BTA-204798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and p85 of PI3K (Bos taurus)
RHEA:71605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(in) + oxaloacetate(out) => 2-oxoglutarate(out) + oxaloacetate(in)
REACT:R-HSA-9624778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD 12mer translocates from ER membrane to extracellular region (Homo sapiens)
REACT:R-DRE-9732527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds rosiglitazone (Danio rerio)
REACT:R-MMU-909732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT2 (Mus musculus)
REACT:R-RNO-156673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF23 (MKLP1) by phosphorylation (Rattus norvegicus)
RHEA:70907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)
RHEA:33081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine + dehypoxanthine futalosine => 6-amino-6-deoxyfutalosine + H2O
RHEA:25070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + ATP + CoA = 3-hydroxybenzoyl-CoA + AMP + diphosphate
RHEA:25070	skos:altLabel	"3-hydroxybenzoate--coenzyme A ligase (AMP-forming)"
RHEA:25070	skos:prefLabel	"3-hydroxybenzoate--CoA ligase"
RHEA:25070	skos:altLabel	"3-hydroxybenzoyl-CoA synthetase"
RHEA:25070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxybenzoate--CoA ligase"
RHEA:48243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GD1b <=> CMP + ganglioside GT1b + H(+)
RHEA:20611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-D-arabinonate
REACT:R-HSA-2179293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)
REACT:R-RNO-139909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BMF to mitochondria (Rattus norvegicus)
REACT:R-HSA-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Homo sapiens)
REACT:R-DRE-1614362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Danio rerio)
RHEA:47496	skos:altLabel	"alpha-hydroxy-cholanate dehydrogenase"
RHEA:47496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + NADP(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADPH
RHEA:47496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha-hydroxycholanate dehydrogenase (NADP(+))"
RHEA:47496	skos:prefLabel	"3alpha-hydroxycholanate dehydrogenase (NADP(+))"
REACT:R-DDI-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Dictyostelium discoideum)
REACT:R-RNO-8875523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds TNS3 (Rattus norvegicus)
RHEA:67238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA => mycophenolyl-CoA + propanoyl-CoA
REACT:R-CEL-9610154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated MAP2Ks and MAPKs (Caenorhabditis elegans)
REACT:R-DME-9654054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DRD2 antagonist drugs bind to DRD2 (Drosophila melanogaster)
REACT:R-DME-448963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of MyoD:E protein with MEF2 (Drosophila melanogaster)
RHEA:17811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine => Mg-protoporphyrin IX + S-adenosyl-L-methionine
GO:0016430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (adenine-N6-)-methyltransferase activity
GO:0016430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an adenosine in tRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine
GO:0016430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity
GO:0016430	skos:prefLabel	"tRNA (adenine-N(6)-)-methyltransferase"
GO:0016430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (adenine-N(6)-)-methyltransferase"
GO:0016430	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity
RHEA:20631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + phosphate => H2O + O-phospho-L-seryl-[protein]
RHEA:51620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + formate + H(+) = CO2 + dCTP + H2O
REACT:R-MMU-176116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment and activation of Chk1 (Mus musculus)
REACT:R-XTR-8982667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises  dR1P to dR5P (Xenopus tropicalis)
REACT:R-GGA-9753285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)
REACT:R-GGA-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Gallus gallus)
REACT:R-HSA-8876789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARNMT1 methylates CARN to Anserine (Homo sapiens)
REACT:R-CFA-8952807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y693-STAT4 dissociates after IL12:IL12R interaction (Canis familiaris)
GO:0090722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hetero-receptor complex formation
GO:0090722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor-receptor interaction
REACT:R-RNO-429571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Rattus norvegicus)
RHEA:16582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 => 2 Fe(III)-[cytochrome c] + 2 H2O
REACT:R-BTA-8933635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Bos taurus)
REACT:R-XTR-909718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of p-STAT1 homodimer (Xenopus tropicalis)
RHEA:21026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + oxalyl-CoA => CoA + glyoxylate + NADP(+)
RHEA:14739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic CMP + diphosphate => CTP
GO:0043763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP:glucose-1-phosphate uridylyltransferase regulator activity
GO:0043763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose diphosphorylase regulator activity
GO:0043763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose pyrophosphorylase regulator activity
GO:0043763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose-1-phosphate uridylyltransferase regulator activity
RHEA:11705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N-(carboxyaminomethyl)urea => CO2 + N-(aminomethyl)urea
EC:1.1.1.87	skos:altLabel	"2-hydroxy-3-carboxyadipate dehydrogenase"
EC:1.1.1.87	skos:altLabel	"3-carboxy-2-hydroxyadipate dehydrogenase"
EC:1.1.1.87	skos:altLabel	"3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating)"
EC:1.1.1.87	skos:altLabel	"homoisocitric dehydrogenase"
EC:1.1.1.87	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homoisocitrate dehydrogenase"
EC:1.1.1.87	skos:altLabel	"(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating)"
EC:1.1.1.87	skos:prefLabel	"homoisocitrate dehydrogenase"
REACT:R-CFA-73647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)
RHEA:69559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose(out) + H(+)(out) <=> D-glucose(in) + H(+)(in)
REACT:R-DRE-5358340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoproteolytic cleavage of Hh precursors (Danio rerio)
RHEA:59825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + pyridoxamine 5'-phosphate => L-glutamate + pyridoxal 5'-phosphate
RHEA:58050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA
REACT:R-SCE-1299297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of THIK (Saccharomyces cerevisiae)
RHEA:12233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) => [thioredoxin]-dithiol + glycine + H(+) + phosphate
RHEA:60222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2
RHEA:43228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine
RHEA:39585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH
REACT:R-HSA-72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of eIF4E from the inactive eIF4E:4E-BP complex  (Homo sapiens)
RHEA:30933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + L,L-cystathionine => L-cysteine + O-acetyl-L-homoserine
REACT:R-XTR-443783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NUMB with L1 (Xenopus tropicalis)
RHEA:72141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + H(+)(in) => estrone 3-sulfate(in) + H(+)(out)
REACT:R-BTA-5691006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Bos taurus)
RHEA:39170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CO2 + CoA
REACT:R-BTA-2076419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Bos taurus)
RHEA:11085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-L-gulonate + H(+) => CO2 + L-xylulose
RHEA:30220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfone + H(+) + NADH
GO:0018548	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	xenobiotic reductase activity
GO:0018548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pentaerythritol trinitrate reductase activity
REACT:R-PFA-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Plasmodium falciparum)
REACT:R-RNO-8952137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)
GO:0008964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate carboxylase activity
GO:0008964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphate:oxaloacetate carboxy-lyase (phosphorylating)
GO:0008964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEPC
GO:0008964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)
GO:0008964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvic carboxylase activity
GO:0008964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEP carboxylase activity
GO:0008964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate (phosphate) carboxylase activity
GO:0008964	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEPCase activity
REACT:R-MMU-914182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)
REACT:R-DRE-6806610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filament formation (Danio rerio)
REACT:R-DDI-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Dictyostelium discoideum)
REACT:R-RNO-1482827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Rattus norvegicus)
REACT:R-SSC-5634228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 is cleaved by caspases (Sus scrofa)
REACT:R-HSA-432897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ILK interacts with beta-1 integrin (Homo sapiens)
REACT:R-GGA-1227860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH homolog downregulates MDA5/IPS1 signaling   (Gallus gallus)
REACT:R-XTR-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Xenopus tropicalis)
GO:0050240	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)
GO:0050240	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrogallol 1,2-dioxygenase activity
GO:0050240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrogallol 1,2-oxygenase activity
RHEA:25703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]
RHEA:37337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(carbamoylamino)-2-methylpropanoate + H(+) => 5,6-dihydrothymine + H2O
REACT:R-MMU-8987084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)
RHEA:23910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine => H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine
REACT:R-HSA-8862700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMKLR1 binds Resolvin E1 (Homo sapiens)
REACT:R-DRE-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Danio rerio)
RHEA:71124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeate + ATP + H(+) + 2 malonyl-CoA => AMP + 2 CO2 + 2 CoA + diphosphate + hispidin
REACT:R-SSC-9027607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Sus scrofa)
REACT:R-HSA-112381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
REACT:R-SSC-1472121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of p-KIT on Y900 by Src kinases (Sus scrofa)
RHEA:34240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate => 3-aminopentanedioate
REACT:R-DRE-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Danio rerio)
RHEA:44643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + ATP <=> a 2'-deoxyribonucleoside 5'-triphosphate + ADP
REACT:R-DRE-193143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates TEST to EST17b (Danio rerio)
REACT:R-SSC-71445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Sus scrofa)
RHEA:59788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH
REACT:R-RNO-9011595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTZ1 dimer dehalogenates DCA to glyoxylate (Rattus norvegicus)
REACT:R-GGA-8949649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Gallus gallus)
REACT:R-MMU-212706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipase C-gamma1 binds to the activated EGF receptor (Mus musculus)
RHEA:33899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose = FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose
RHEA:33899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase"
RHEA:33899	skos:altLabel	"decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase"
RHEA:33899	skos:prefLabel	"decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase"
REACT:R-CFA-205008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated NRIF binds to p62 (Sequestosome) (Canis familiaris)
GO:0030755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quercetin 3-O-methyltransferase activity
GO:0030755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonol 3-O-methyltransferase activity
GO:0030755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity
GO:0030755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonoid 3-methyltransferase activity
REACT:R-SSC-5218642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates (Sus scrofa)
GO:0102935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenin-UDP-glucosyltransferase activity
REACT:R-MMU-6787533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Mus musculus)
REACT:R-RNO-9029551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Rattus norvegicus)
RHEA:56841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-2-hydroxybenzoate + O2 => (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)
REACT:R-HSA-1454791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP2, MMP7, MMP9 bind CD44 (Homo sapiens)
RHEA:52062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-octadecenoyloxy)-octadecanoate + H2O
REACT:R-DME-201422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Drosophila melanogaster)
REACT:R-BTA-9648017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 binds to microtubules (Bos taurus)
REACT:R-DRE-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Danio rerio)
RHEA:49481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + L-1-piperideine-6-carboxylate + NADP(+) => H(+) + L-2-aminoadipate + NADPH
RHEA:67137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + ADP + phosphate
GO:0102906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-epi-alpha-selinene synthase activity
REACT:R-HSA-76386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1A2 S-demethylates 6MMP (Homo sapiens)
REACT:R-CEL-165026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Caenorhabditis elegans)
RHEA:10242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2E)-enoyl-[ACP] + H(+) + NADH => a 2,3-saturated acyl-[ACP] + NAD(+)
REACT:R-GGA-110234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of ethenocytosine by TDG glycosylase  (Gallus gallus)
REACT:R-CEL-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)
REACT:R-SSC-196761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xTPK1:Mg2+ phosphorylates THMN (Sus scrofa)
RHEA:20193	skos:prefLabel	"mevaldate reductase (NADPH)"
RHEA:20193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mevaldate reductase (NADPH)"
RHEA:20193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH
REACT:R-HSA-174164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Homo sapiens)
RHEA:46562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-GGA-8851804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET recruits GRB2-1:SOS1 (Gallus gallus)
RHEA:43020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L,L-cystathionine = 2-aminoprop-2-enoate + L-homocysteine
REACT:R-RNO-5685319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex formation (Rattus norvegicus)
REACT:R-RNO-975139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Rattus norvegicus)
RHEA:57278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + glyoxal
RHEA:29081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate + ubiquinol-8 => (R)-lactate + ubiquinone-8
GO:0008458	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	overt mitochondrial carnitine palmitoyltransferase
GO:0008458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnitine medium-chain acyltransferase activity
GO:0008458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnitine O-octanoyltransferase activity
GO:0008458	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	easily solubilized mitochondrial carnitine palmitoyltransferase
GO:0008458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	octanoyl-CoA:L-carnitine O-octanoyltransferase activity
GO:0008458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	medium-chain/long-chain carnitine acyltransferase activity
REACT:R-HSA-9026917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA (Homo sapiens)
REACT:R-CFA-3341277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
REACT:R-DME-5696007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF3 ligates CoA-SH to VLCFA (Drosophila melanogaster)
RHEA:59007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + H2O + O2 <=> dodecanoate + H(+) + H2O2
GO:0048407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	platelet-derived growth factor binding
GO:0048407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF binding
RHEA:11010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O
RHEA:25669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> beta-pinene + diphosphate
RHEA:51543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-199014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD96 binds PVR (Mus musculus)
RHEA:72350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole <=> 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
REACT:R-CFA-2022141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolysyl oxidase activation (Canis familiaris)
REACT:R-CFA-216045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I binds integrin alpha11beta1 (Canis familiaris)
REACT:R-XTR-9634702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Xenopus tropicalis)
REACT:R-DME-168440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Drosophila melanogaster)
RHEA:55406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n+1) + UDP => [phosphate](n) + UTP
REACT:R-XTR-216043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II binds integrin alpha10beta1 (Xenopus tropicalis)
REACT:R-BTA-8951486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C4b (Bos taurus)
REACT:R-MMU-1861595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extension of pseudopodia by myosin-X in a PI3K dependent manner (Mus musculus)
REACT:R-CEL-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Caenorhabditis elegans)
REACT:R-HSA-9755765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA (Homo sapiens)
REACT:R-DDI-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Dictyostelium discoideum)
REACT:R-BTA-2424252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMP binds collagen, fibronectin, aggrecan and matrilins (Bos taurus)
GO:0044318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-aspartate oxidase"
GO:0044318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate:fumarate oxidoreductase activity
GO:0044318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + O2 = H2O2 + iminosuccinate
GO:0044318	skos:altLabel	"LASPO"
GO:0044318	skos:prefLabel	"L-aspartate oxidase"
RHEA:11572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + H2O + lithocholate = chenodeoxycholate + FADH2
REACT:R-BTA-6784791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Bos taurus)
GO:0052897	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming) activity
GO:0052897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming)"
GO:0052897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
GO:0052897	skos:prefLabel	"N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming)"
REACT:R-HSA-8952399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 translocates to the cytosol (Homo sapiens)
RHEA:35350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O
GO:0048101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity
GO:0048101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity
GO:0048101	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	calcium- and calmodulin-regulated cGMP phosphodiesterase activity
GO:0048101	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity
GO:0003786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin lateral binding
RHEA:35325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+)
REACT:R-RNO-5622129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABP5 binds atRA (Rattus norvegicus)
RHEA:65691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine
RHEA:47122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-docosanoylglycine => docosanoate + glycine
RHEA:29136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + 2 H(+)(in) + nitrate => a menaquinone + 2 H(+)(out) + H2O + nitrite
REACT:R-HSA-186765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-gamma binds to the active receptor (Homo sapiens)
RHEA:41355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine
REACT:R-HSA-417829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds ADP (Homo sapiens)
RHEA:53783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-muricholate + lithocholoyl-CoA <=> beta-muricholoyl-CoA + lithocholate
RHEA:50110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-hexadecanoyl-taurine => hexadecanoyl-CoA + taurine
RHEA:72939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + propanoate(out) = 2 Na(+)(in) + propanoate(in)
REACT:R-CFA-5690152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP5 cleaves polyubiquitin (Canis familiaris)
RHEA:60747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin I
REACT:R-BTA-193101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11A1 cleaves 20a,22b-DHCHOL (Bos taurus)
RHEA:25907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	futalosine + H2O <=> dehypoxanthine futalosine + hypoxanthine
GO:0106151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNBH domain intrinsic ligand binding
REACT:R-GGA-8855375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN22 dissociates from CSK (Gallus gallus)
RHEA:35278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoyl-CoA + NAD(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADH
RHEA:37593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA
REACT:R-RNO-2187401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)
RHEA:72914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proatranorin III + S-adenosyl-L-methionine <=> atranorin + S-adenosyl-L-homocysteine
RHEA:27708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-alanyl-D-serine + H(+) + phosphate => ATP + D-alanine + D-serine
REACT:R-DRE-9690493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB binds effectors on endosomes (Danio rerio)
REACT:R-SSC-192422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular PTL:colipase (Sus scrofa)
RHEA:15633	skos:altLabel	"homoprotocatechuate 2,3-dioxygenase"
RHEA:15633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)
RHEA:15633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,4-dihydroxyphenylacetate 2,3-dioxygenase"
RHEA:15633	skos:altLabel	"HPC dioxygenase"
RHEA:15633	skos:prefLabel	"3,4-dihydroxyphenylacetate 2,3-dioxygenase"
RHEA:62815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 monapinone A + O2 <=> 2 dinapinone A + 2 H2O
REACT:R-HSA-9637638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esxA binds TLR2 (Homo sapiens)
EC:2.4.1.97	skos:prefLabel	"1,3-beta-D-glucan phosphorylase"
EC:2.4.1.97	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,3-beta-D-glucan phosphorylase"
EC:2.4.1.97	skos:altLabel	"laminarin phosphorylase"
RHEA:61306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose
REACT:R-XTR-8851804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET recruits GRB2-1:SOS1 (Xenopus tropicalis)
RHEA:68942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na(+)(out) + tellurite(out) => Na(+)(in) + tellurite(in)
REACT:R-CFA-349637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spherical HDL and SR-BI receptor form a complex at the cell surface (Canis familiaris)
GO:0015308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amiloride:hydrogen antiporter activity
GO:0015308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amiloride:proton antiporter activity
REACT:R-XTR-191983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)
REACT:R-SSC-8847637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind the cis-SNARE at the Golgi (Sus scrofa)
REACT:R-SCE-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Saccharomyces cerevisiae)
REACT:R-RNO-77614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR1) (Rattus norvegicus)
REACT:R-SSC-166721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Sus scrofa)
GO:0140677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	molecular function activator activity
RHEA:14159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + phosphate => H2O + triphosphate
RHEA:40232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-2730847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
RHEA:46791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0050034	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnofuranose:NAD+ 1-oxidoreductase activity
GO:0050034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnose 1-dehydrogenase activity
REACT:R-CFA-5675431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates RAF1 (Canis familiaris)
RHEA:34312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol + NADH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite
RHEA:47568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GD1b (d18:1(4E)) + H(+) + UDP
RHEA:22326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leukotriene B4 => H2O + leukotriene A4
REACT:R-RNO-8982165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Rattus norvegicus)
REACT:R-GGA-5627275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOPC promotes translocation of CFTR to lysosomes (Gallus gallus)
REACT:R-HSA-5686685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)
REACT:R-MMU-8850945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Casein kinase II phosphorylates PTEN (Mus musculus)
RHEA:50627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O <=> a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)
GO:0140787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate ion uniporter activity
REACT:R-DRE-5696627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Danio rerio)
REACT:R-CFA-9726580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGR binds PGR agonists (Canis familiaris)
REACT:R-HSA-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Homo sapiens)
REACT:R-HSA-9698029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from mutant FLT3 (Homo sapiens)
REACT:R-XTR-3296126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Xenopus tropicalis)
REACT:R-SSC-9714477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the mitochondrial outer membrane (Sus scrofa)
EC:3.4.24.1	skos:altLabel	"Crotalus atrox metalloproteinase"
EC:3.4.24.1	skos:altLabel	"Crotalus atrox alpha-proteinase"
EC:3.4.24.1	skos:prefLabel	"atrolysin A"
EC:3.4.24.1	skos:altLabel	"hemorrhagic toxin a"
EC:3.4.24.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"atrolysin A"
REACT:R-RNO-1602374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Rattus norvegicus)
RHEA:23294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-phospho-L-lombricine => ATP + L-lombricine
RHEA:14382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanal + H2O + NAD(+) => 4-guanidinobutanoate + 2 H(+) + NADH
REACT:R-HSA-166869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 binds MEKK1 (Homo sapiens)
REACT:R-SSC-203567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylation of eNOS (Sus scrofa)
RHEA:60084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADH
REACT:R-GGA-109538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Gallus gallus)
GO:0052774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosyl-N-acetylglucosamine glucosaminidase activity
REACT:R-BTA-4641246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 autoubiquitinates to promote its internalization (Bos taurus)
RHEA:54726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine
GO:0050254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhodopsin kinase activity
GO:0050254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	opsin kinase activity
GO:0050254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhodopsin kinase (phosphorylating) activity
GO:0050254	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GPCR kinase 1 activity
GO:0050254	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cone opsin kinase activity
GO:0050254	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	opsin kinase (phosphorylating) activity
REACT:R-CFA-422017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase decanoylates Proghrelin (Canis familiaris)
RHEA:20705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + acetyl-CoA => an N-acetyl-D-amino acid + CoA + H(+)
REACT:R-RNO-190065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TrkA receptor internalizes to endosomes (Rattus norvegicus)
RHEA:16629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malyl-CoA = acetyl-CoA + glyoxylate
RHEA:12498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 4 H2O + O2
RHEA:64239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atrochrysone carboxyl-[ACP] + H2O <=> atrochrysone carboxylate + H(+) + holo-[ACP]
REACT:R-MMU-419166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GEFs activate RhoA,B,C (Mus musculus)
RHEA:68624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"C-phycoerythrin alpha-cysteine-82 phycoerythrobilin lyase"
RHEA:68624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]
RHEA:68624	skos:prefLabel	"C-phycoerythrin alpha-cysteine-82 phycoerythrobilin lyase"
REACT:R-SSC-77303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Sus scrofa)
REACT:R-DRE-5205681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is cleaved on healthy mitochondria (Danio rerio)
REACT:R-DRE-5333051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPA1 binds HSF1 (Danio rerio)
RHEA:65404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + hexanoyl-CoA = butyl hexanoate + CoA
GO:0034527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity
REACT:R-HSA-5654406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
RHEA:64124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-L-phenylalanine = hexadecanoate + L-phenylalanine
REACT:R-HSA-6784598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPPA(124-151) binds NPR1 (Homo sapiens)
RHEA:53658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate => (5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2
REACT:R-DDI-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Dictyostelium discoideum)
REACT:R-MMU-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Mus musculus)
REACT:R-SCE-428185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine + stearyl-CoA => dihydroceramide + CoASH (Saccharomyces cerevisiae)
RHEA:52187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:34236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitro-6-oxohepta-2,4-dienedioate => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite
REACT:R-CFA-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Canis familiaris)
REACT:R-DDI-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
REACT:R-MMU-5675470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC2/3 (cIAP1/2) is autoubiquitinated (Mus musculus)
GO:0005469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinate:fumarate antiporter activity
REACT:R-SSC-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Sus scrofa)
RHEA:22354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cadaverine + CO2 => H(+) + L-lysine
RHEA:57591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-9638075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from DS (Xenopus tropicalis)
RHEA:61525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 => (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate
GO:0005035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	death receptor activity
GO:0005035	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	apoptosis-activating receptor activity
REACT:R-DME-2730862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of LYN kinase (Drosophila melanogaster)
REACT:R-GGA-5652009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Gallus gallus)
REACT:R-SSC-1237129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acireductone is created (Sus scrofa)
REACT:R-HSA-9672159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to p-11Y PDGFRA extracellular domain dimers  (Homo sapiens)
REACT:R-XTR-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
RHEA:45395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine
RHEA:29324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + succinate(out) => fumarate(out) + succinate(in)
REACT:R-PFA-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Plasmodium falciparum)
RHEA:10939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-decylubiquinone + 2 thiosulfate <=> 6-decylubiquinol + tetrathionate
RHEA:54264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate
REACT:R-XTR-374896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uptake of Noradrenaline (Xenopus tropicalis)
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-alpha-mannosidase
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mannosidase 1B activity
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ManI activity
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mannose-9 processing alpha-mannosidase activity
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-alpha-1,2-mannanase activity
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoprotein processing mannosidase I
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Man9-mannosidase activity
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	mannosidase 1A activity
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0004571	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	mannosidase I
REACT:R-BTA-187545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cks1 with SCF(Skp2) complex (Bos taurus)
RHEA:40461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-pristenoyl-CoA + H2O2 => (2S)-pristanoyl-CoA + O2
REACT:R-RNO-2186767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SKI/SKIL (Rattus norvegicus)
RHEA:44509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-SSC-5617138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)
RHEA:16921	skos:altLabel	"UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase"
RHEA:16921	skos:altLabel	"uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase"
RHEA:16921	skos:altLabel	"alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase"
RHEA:16921	skos:prefLabel	"alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase"
RHEA:16921	skos:altLabel	"GnTV"
RHEA:16921	skos:altLabel	"GlcNAc-T V"
RHEA:16921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
RHEA:16921	skos:altLabel	"alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase"
RHEA:16921	skos:altLabel	"N-acetylglucosaminyltransferase V"
RHEA:16921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase"
REACT:R-MMU-187895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)
REACT:R-DRE-389550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)
REACT:R-GGA-8852013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTNL8 binds resting T cell surface (Gallus gallus)
REACT:R-MMU-389842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO1 tetramer oxidizes glycolate to glyoxylate (Mus musculus)
REACT:R-SSC-5626962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB2L1 binds IKKA:IKKB:NEMO (Sus scrofa)
RHEA:25519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + tropine <=> CoA + H(+) + O-acyltropine
REACT:R-CFA-399933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sema3A binds Nrp-1 bound to PlexinA (Canis familiaris)
RHEA:29415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)
GO:0015018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity
GO:0015018	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glucuronosyltransferase I activity
GO:0015018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
GO:0015018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity
GO:0015018	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity
EC:1.14.99.53	skos:prefLabel	"lytic chitin monooxygenase"
EC:1.14.99.53	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lytic chitin monooxygenase"
EC:1.14.99.53	skos:altLabel	"chitin oxidohydrolase"
EC:1.14.99.53	skos:altLabel	"LPMO"
RHEA:56591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monosubstituted aliphatic (S)-hydroxynitrile <=> an aldehyde + hydrogen cyanide
RHEA:49149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine
REACT:R-GGA-4641246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZNRF3 autoubiquitinates to promote its internalization (Gallus gallus)
REACT:R-BTA-9749505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC14 binds IKBKB and CHUK (Bos taurus)
REACT:R-HSA-751029	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Homo sapiens)
RHEA:62155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dGMP + dTTP <=> dGDP + dTDP
REACT:R-RNO-74743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-Y427-SHC1 from insulin receptor (Rattus norvegicus)
RHEA:53382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NAD(+)
REACT:R-HSA-2162227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses (HA)2 (Homo sapiens)
REACT:R-MMU-4722133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Mus musculus)
RHEA:72895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine = 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylthioadenosine phosphorylase activity
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-methylthioadenosine phosphorylase activity
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MeSAdo phosphorylase activity
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MTA phosphorylase activity
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MTAPase activity
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methylthioadenosine nucleoside phosphorylase activity
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MeSAdo/Ado phosphorylase activity
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-methyl-5-thioadenosine phosphorylase activity
GO:0017061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-deoxy-5'-methylthioadenosine phosphorylase activity
REACT:R-MMU-8987150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Mus musculus)
REACT:R-XTR-8875591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK7 activates RAC1 (Xenopus tropicalis)
RHEA:51249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate
RHEA:59814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein] => hexadecanoyl-CoA + N-terminal glycyl-[protein]
REACT:R-HSA-9755747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 N binds MAVS (Homo sapiens)
GO:0008273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium, potassium:sodium antiporter activity
GO:0008273	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	potassium-dependent sodium/calcium exchanger
REACT:R-HSA-5674366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RD binds p-2S MAP2Ks and MAPKs (Homo sapiens)
REACT:R-GGA-202214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)
REACT:R-RNO-380303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Phospho-Nlp from the centrosome (Rattus norvegicus)
REACT:R-BTA-909730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of INFAR1 by TYK2 (Bos taurus)
GO:0045431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 = a flavonol + CO2 + H2O + succinate
GO:0045431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity
GO:0045431	skos:altLabel	"flavonoid 2-oxoglutarate-dependent dioxygenase"
GO:0045431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonol synthase"
GO:0045431	skos:prefLabel	"flavonol synthase"
GO:0045431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	flavonoid 2-oxoglutarate-dependent dioxygenase activity
GO:0045431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavonol synthase activity
GO:0045431	skos:altLabel	"FLS"
GO:0045431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	FLS activity
RHEA:47616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethionamide + H(+) + NADPH + O2 = ethionamide S-oxide + H2O + NADP(+)
REACT:R-RNO-9708423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1:BACH1:Hemes are transported out of the nucleus (Rattus norvegicus)
RHEA:51176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
GO:0008397	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP8B1
GO:0008397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol 12-alpha-hydroxylase activity
REACT:R-BTA-3249371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylates STAT6 at Ser407 (Bos taurus)
REACT:R-DRE-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Danio rerio)
REACT:R-SCE-174391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)
RHEA:69525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol + O2 => D-glucose + H2O2
GO:0032393	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	T cell receptor activity
GO:0032393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class I receptor activity
GO:0032393	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-beta T cell receptor activity
GO:0032393	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-delta T cell receptor activity
REACT:R-DRE-193641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKK-beta is recruited (Danio rerio)
REACT:R-BTA-389026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galanin receptors can bind galanin (Bos taurus)
RHEA:35328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoyl-CoA + H(+) + malonyl-CoA => 3-oxodocosanoyl-CoA + CO2 + CoA
RHEA:59499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Caenorhabditis elegans)
REACT:R-DRE-4088264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Danio rerio)
REACT:R-DRE-5682018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to shortened telomeres recruits ATM (Danio rerio)
REACT:R-RNO-9024881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Rattus norvegicus)
RHEA:49920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)
GO:0047069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydroxykynurenate:oxygen 8,8alpha-oxidoreductase (decyclizing)
GO:0047069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydroxykynurenate oxygenase activity
GO:0047069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroxykynurenate 8,8a-dioxygenase activity
GO:0047069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity
GO:0047069	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)
RHEA:41823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-SSC-6784738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Sus scrofa)
REACT:R-GGA-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Gallus gallus)
RHEA:14871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O
REACT:R-CFA-8953013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 binds E2F8 (Canis familiaris)
REACT:R-XTR-1675988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Xenopus tropicalis)
RHEA:41095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine + sphing-4-enine
REACT:R-MMU-8855954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Mus musculus)
REACT:R-HSA-5696358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREM,CD300 binds lipids (Homo sapiens)
RHEA:48169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine => N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate
RHEA:69665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucose + luteolin => H2O + luteolin 7-O-beta-D-glucoside
RHEA:27985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-carboxy-7-deazaguanine + ATP + NH4(+) <=> 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate
RHEA:47923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM2 (d18:1(4E)/18:0) + H2O <=> ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate
RHEA:11747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine triphosphate <=> H(+) + phosphate + thiamine diphosphate
REACT:R-DME-210805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of miRNA passenger strand (Drosophila melanogaster)
REACT:R-GGA-1237325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A is protonated and carbamated causing release of oxygen (Gallus gallus)
GO:0018663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypyridine 3-monooxygenase activity
GO:0018663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypyridine oxidase activity
GO:0018663	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)
RHEA:67817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O => a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate
RHEA:58716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2-C4alpha-hydroperoxide + NADH + rifampicin = FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal
RHEA:22404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + H(+) + NADH
GO:0034783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pivalate-CoA ligase activity
REACT:R-SSC-8873923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD10 binds LPCAT1 and PC (Sus scrofa)
REACT:R-RNO-8877311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB31 GEFs exchange GTP for GDP on RAB31 (Rattus norvegicus)
REACT:R-RNO-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Rattus norvegicus)
RHEA:27524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-formylmaleamate => 2,5-dihydroxypyridine + O2
REACT:R-XTR-175983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfer CH3 from AdoMet to 3,4DHBNZ (Xenopus tropicalis)
REACT:R-CEL-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Caenorhabditis elegans)
RHEA:28447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxy-D-xylulose(in) => 1-deoxy-D-xylulose(out)
EC:1.1.5.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclic alcohol dehydrogenase (quinone)"
EC:1.1.5.7	skos:altLabel	"MCAD"
EC:1.1.5.7	skos:altLabel	"cyclic alcohol dehydrogenase"
EC:1.1.5.7	skos:prefLabel	"cyclic alcohol dehydrogenase (quinone)"
REACT:R-CEL-389540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)
REACT:R-HSA-5621402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CP does not oxidise Fe2+ to Fe3+ (Homo sapiens)
REACT:R-SSC-9700154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK binds SHC1 (Sus scrofa)
REACT:R-SCE-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)
GO:0015179	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	L-amino acid transporter activity
GO:0015179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutamine transport from astrocytes (Homo sapiens)
GO:0015179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-amino acid transmembrane transporter activity
REACT:R-DME-3781011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Drosophila melanogaster)
REACT:R-GGA-381543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP4 binds IGF forming IGF:IGFBP4 (Gallus gallus)
RHEA:33793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose + beta-D-glucose 6-phosphate => H2O + sucrose 6(F)-phosphate
RHEA:40652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)
RHEA:24297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + H2O => H(+) + N-carbamoyl-L-aspartate
RHEA:37932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate
REACT:R-SSC-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Sus scrofa)
RHEA:58146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetate + ATP + cytidine(34) in elongator tRNA(Met)
REACT:R-HSA-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)
REACT:R-XTR-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Xenopus tropicalis)
REACT:R-GGA-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Gallus gallus)
RHEA:16087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
REACT:R-BTA-3640861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 ubiquitinates ADP-ribosylated AXIN (Bos taurus)
GO:1990763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arrestin family protein binding
REACT:R-HSA-9020278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Homo sapiens)
RHEA:72270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + formate(in) <=> chloride(in) + formate(out)
RHEA:55369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + H(+) + NADPH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine
REACT:R-CEL-2066778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)
REACT:R-XTR-174195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Xenopus tropicalis)
REACT:R-CFA-6807008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRJ dephosphorylates MET (Canis familiaris)
REACT:R-DME-904864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Drosophila melanogaster)
RHEA:66519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9609739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2C (GRIN2C) (Homo sapiens)
RHEA:31918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-maltose <=> ADP + alpha-maltose 1-phosphate + H(+)
RHEA:64654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumaroyl-CoA + H(+) + NADPH => (E)-4-coumaraldehyde + CoA + NADP(+)
RHEA:55499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-9021079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs:CAVs translocate to plasma membrane (Homo sapiens)
GO:0016737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on reduced flavodoxin as donor
GO:0016737	skos:prefLabel	"Acting on reduced flavodoxin as donor"
GO:0016737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on reduced flavodoxin as donor"
RHEA:23976	skos:altLabel	"RNA-3'-phosphate cyclase"
RHEA:23976	skos:altLabel	"RNA cyclase"
RHEA:23976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate
RHEA:23976	skos:prefLabel	"RNA 3'-terminal-phosphate cyclase (ATP)"
RHEA:23976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RNA 3'-terminal-phosphate cyclase (ATP)"
REACT:R-BTA-5684868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-SFTPC translocates from ER membrane to multivesicle body (Bos taurus)
REACT:R-CFA-9679775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT binds COMT Inhibitors (Canis familiaris)
REACT:R-HSA-179410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Nek2A with MCC:APC/C (Homo sapiens)
RHEA:17994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-alanine + gamma-L-glutamyl-L-cysteine => ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate
RHEA:52534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + GDP + H(+) => adenosine + GTP
REACT:R-DRE-8983063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Danio rerio)
RHEA:49854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-CoA => (3E)-octenoyl-CoA
RHEA:43162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine => adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine
RHEA:34571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"botryococcene synthase"
RHEA:34571	skos:prefLabel	"botryococcene synthase"
RHEA:34571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C30 botryococcene + diphosphate + NADP(+) = H(+) + NADPH + presqualene diphosphate
RHEA:68222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA => (7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol
RHEA:42799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + cholesterol <=> cholesteryl (9Z,12Z)-octadecadienoate + CoA
REACT:R-MMU-166726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MASPs (Mus musculus)
RHEA:15448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + O-carbamoyl-L-serine <=> CO2 + 2 NH4(+) + pyruvate
REACT:R-XTR-163809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)
EC:1.14.1.-	skos:prefLabel	"With NADH or NADPH as one donor"
EC:1.14.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NADH or NADPH as one donor"
REACT:R-DDI-5419165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Dictyostelium discoideum)
REACT:R-HSA-417896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y6 receptor can bind to UDP (Homo sapiens)
REACT:R-SSC-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Sus scrofa)
REACT:R-DME-209252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CI75 inhibits transcription (Drosophila melanogaster)
REACT:R-RNO-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Rattus norvegicus)
GO:0008251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-adenosine deaminase activity
GO:0008251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-specific adenosine deaminase activity
RHEA:17365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Mn(2+)(out) = ADP + H(+) + Mn(2+)(in) + phosphate
RHEA:17365	skos:altLabel	"manganese-transporting ATPase"
RHEA:17365	skos:altLabel	"ABC-type manganese permease complex"
RHEA:17365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type Mn(2+) transporter"
RHEA:17365	skos:prefLabel	"ABC-type Mn(2+) transporter"
REACT:R-BTA-2730900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TAK1 complex bound to pUb-TRAF6 (Bos taurus)
RHEA:50496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]
REACT:R-HSA-8936000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds the CLDN5 (Claudin-5) gene promoter (Homo sapiens)
REACT:R-XTR-8878581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYRP1 oxidises DHICA to IQCA (Xenopus tropicalis)
RHEA:47027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)
REACT:R-CFA-5218826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)
RHEA:65585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-8987129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Xenopus tropicalis)
REACT:R-HSA-450257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
REACT:R-GGA-3928601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 and PIP2 bind WASL, activating it (Gallus gallus)
REACT:R-CFA-195304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of beta-catenin with the destruction complex (Canis familiaris)
REACT:R-MMU-110356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of MPG glycosylase by APEX1 at the AP site (Mus musculus)
REACT:R-HSA-2399997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant translocates to the nucleus (Homo sapiens)
GO:0140701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3' cyclic-GMP-AMP synthase activity
GO:0140701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cyclic GMP-AMP synthase activity
GO:0140701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3' cyclic-GAMP synthase activity
GO:0140701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP = 3',3'-cGAMP + 2 diphosphate
GO:0140701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-cyclic GAMP synthase activity
REACT:R-SSC-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Sus scrofa)
RHEA:38774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:53155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-71163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Homo sapiens)
REACT:R-MMU-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Mus musculus)
RHEA:69618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
REACT:R-CFA-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Canis familiaris)
REACT:R-HSA-374916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)
REACT:R-GGA-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Gallus gallus)
RHEA:28440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP] => dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP]
GO:0033923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	exo-isomaltohydrolase activity
GO:0033923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	G2-dextranase activity
GO:0033923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isomalto-dextranase activity
GO:0033923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,6-alpha-D-glucan isomaltohydrolase activity
GO:0033923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucan 1,6-alpha-isomaltosidase activity
GO:0033923	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isomaltodextranase activity
REACT:R-GGA-8941628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)
RHEA:14322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	morphine + NADP(+) => H(+) + morphinone + NADPH
RHEA:39508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)
REACT:R-CEL-5662471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SORD tetramer oxidizes xylitol to D-xylulose (Caenorhabditis elegans)
RHEA:37706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
REACT:R-HSA-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Homo sapiens)
REACT:R-MMU-376122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM/DSCAML1 homodimerization (Mus musculus)
REACT:R-MMU-9626848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Mus musculus)
RHEA:16833	skos:prefLabel	"glutathione peroxidase"
RHEA:16833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutathione peroxidase"
RHEA:16833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 glutathione + H2O2 = glutathione disulfide + 2 H2O
REACT:R-CFA-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Canis familiaris)
RHEA:10109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7S)-salutaridinol + NADP(+) => H(+) + NADPH + salutaridine
REACT:R-HSA-418868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Src and Fyn to DCC:FADK1 (Homo sapiens)
REACT:R-CFA-191380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate is phosphorylated to mevalonate-5-phosphate (Canis familiaris)
REACT:R-CFA-9714363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC translocates to the endoplasmic reticulum membrane (Canis familiaris)
REACT:R-RNO-143468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEOS oxidizes ethanol to acetaldehyde (Rattus norvegicus)
REACT:R-RNO-187020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Part of pro-beta-NGF is processed to mature beta-NGF (Rattus norvegicus)
REACT:R-DME-5671737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1 binds CDC25C (Drosophila melanogaster)
REACT:R-HSA-5682010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10:ATG12 binds ATG5 (Homo sapiens)
GO:0120295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone serotonyltransferase activity
REACT:R-XTR-5684096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK2 phosphorylates RBBP8 (Xenopus tropicalis)
RHEA:16743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + CoA => a 2-acylglycerol + an acyl-CoA
RHEA:58961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzaldehyde + H2O + O2 => benzoate + H(+) + H2O2
RHEA:34144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabinerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2
RHEA:65346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA
REACT:R-DDI-4641342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TOP2A with SUMO1 (Dictyostelium discoideum)
RHEA:67451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxyoctadecanoyl-CoA <=> formyl-CoA + heptadecanal
RHEA:70594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
REACT:R-DRE-5654684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR4 (Danio rerio)
REACT:R-DME-8849353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Drosophila melanogaster)
REACT:R-MMU-373071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR7 binds CCL19 and 21 ligands (Mus musculus)
REACT:R-HSA-5601976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP21A2 does not 21-hydroxylate PROG (Homo sapiens)
REACT:R-HSA-9698265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enhanced autophagosome formation (Homo sapiens)
REACT:R-XTR-6786166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translesion synthesis across unhooked ICL by POLN (Xenopus tropicalis)
RHEA:29923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)
REACT:R-RNO-5696230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO1 dimer reduces methylarsonate to methylarsonite (Rattus norvegicus)
REACT:R-XTR-168166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B complex is transported from cytosol to nucleus (Xenopus tropicalis)
RHEA:56311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-2023456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of FGFR1 point mutants with enhanced kinase activity (Homo sapiens)
RHEA:13655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose => [6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose
RHEA:20430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin + S-adenosyl-L-methionine => acacetin + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-176879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein(a) + LDL => Lp(a) (Canis familiaris)
RHEA:45265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate(out) => (9Z,12Z)-octadecadienoate(in)
REACT:R-MMU-1482604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Mus musculus)
RHEA:53313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:13975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + 2 phosphate => diphosphate + H(+)(in) + H2O
REACT:R-SSC-5218832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds PAK2 (Sus scrofa)
RHEA:28205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]
GO:0047578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyglutamate transaminase activity
GO:0047578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyglutamate aminotransferase activity
GO:0047578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity
RHEA:25623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tuberculosinyl diphosphate => geranylgeranyl diphosphate
RHEA:18651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-galactonate + H2O => D-galactonate
REACT:R-CFA-6781905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZRANB1 binds APC (Canis familiaris)
REACT:R-CEL-3247493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO1 (Caenorhabditis elegans)
GO:0033612	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transmembrane receptor protein serine/threonine kinase ligand binding
GO:0033612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	receptor serine/threonine kinase binding
REACT:R-DRE-9750016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Danio rerio)
REACT:R-RNO-5683384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UIMC1 and FAM175A bind DNA DSBs (Rattus norvegicus)
RHEA:32172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + phenylacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)
RHEA:17381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"linoleate isomerase"
RHEA:17381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate = (9Z,11E)-octadecadienoate
RHEA:17381	skos:prefLabel	"linoleate isomerase"
GO:0050042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactate--malate transhydrogenase"
GO:0050042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malate-lactate transhydrogenase activity
GO:0050042	skos:prefLabel	"lactate--malate transhydrogenase"
GO:0050042	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-lactate:oxaloacetate oxidoreductase activity
GO:0050042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + oxaloacetate = (S)-malate + pyruvate
GO:0050042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactate-malate transhydrogenase activity
REACT:R-SCE-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Saccharomyces cerevisiae)
RHEA:14608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + GDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + GDP + H(+)
REACT:R-CFA-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Canis familiaris)
REACT:R-MMU-429441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK activation by SRC (Mus musculus)
RHEA:19629	skos:altLabel	"isocitrate dehydrogenase (NADP)"
RHEA:19629	skos:altLabel	"triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase"
RHEA:19629	skos:altLabel	"NADP-linked isocitrate dehydrogenase"
RHEA:19629	skos:altLabel	"isocitrate dehydrogenase (NADP-dependent)"
RHEA:19629	skos:altLabel	"NADP(+)-ICDH"
RHEA:19629	skos:altLabel	"IDP"
RHEA:19629	skos:altLabel	"isocitrate (NADP) dehydrogenase"
RHEA:19629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isocitrate dehydrogenase (NADP(+))"
RHEA:19629	skos:altLabel	"NADP(+)-IDH"
RHEA:19629	skos:altLabel	"dual-cofactor-specific isocitrate dehydrogenase"
RHEA:19629	skos:altLabel	"IDH"
RHEA:19629	skos:altLabel	"oxalosuccinate decarboxylase"
RHEA:19629	skos:altLabel	"oxalsuccinic decarboxylase"
RHEA:19629	skos:prefLabel	"isocitrate dehydrogenase (NADP(+))"
RHEA:19629	skos:altLabel	"NADP-dependent isocitrate dehydrogenase"
RHEA:19629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH
RHEA:19629	skos:altLabel	"NADP isocitric dehydrogenase"
RHEA:19629	skos:altLabel	"NADP-specific isocitrate dehydrogenase"
RHEA:19629	skos:altLabel	"isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase"
RHEA:19629	skos:altLabel	"NADP-dependent isocitric dehydrogenase"
RHEA:19629	skos:altLabel	"NADP(+)-linked isocitrate dehydrogenase"
REACT:R-HSA-159733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor X to factor X (Homo sapiens)
RHEA:14672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + H2O + NADP(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADPH
REACT:R-GGA-8949668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YME1L1 proteolyzes unassembled proSMDT1 (Gallus gallus)
REACT:R-CFA-75082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Canis familiaris)
REACT:R-RNO-1234172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear VBC complex ubiquitinylates HIF-alpha (Rattus norvegicus)
REACT:R-GGA-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Gallus gallus)
REACT:R-CEL-8952638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)
GO:0071424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rRNA (cytosine-N4-)-methyltransferase activity
GO:0071424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-5419269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSFM binds TUFM displacing GDP (Homo sapiens)
GO:0030883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endogenous lipid antigen binding
RHEA:40485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O
GO:0106409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-di-AMP phosphodiesterase activity
REACT:R-XTR-195408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Xenopus tropicalis)
RHEA:50738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + thiosulfate => a quinone + 2 H(+) + hydrogen sulfide + sulfite
REACT:R-CFA-8848338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes TAG (Canis familiaris)
RHEA:45538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine => H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
RHEA:70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-[ACP]
REACT:R-RNO-5213464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 is phosphorylated (Rattus norvegicus)
REACT:R-GGA-6799097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates ZNF420 (Gallus gallus)
RHEA:65359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
REACT:R-DDI-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)
RHEA:40567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 = A + dTDP-beta-L-evernitrose + H2O
RHEA:63950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + sphinga-4E,14Z-dienine => H2O + sphinga-4E,14Z-dienine-1-phosphate
REACT:R-MMU-6804468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SP3 with SUMO2 (Mus musculus)
GO:0008932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptidoglycan lytic endotransglycosylase"
GO:0008932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lytic endotransglycosylase activity
GO:0008932	skos:prefLabel	"peptidoglycan lytic endotransglycosylase"
GO:0008932	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	murein lytic endotransglycosylase E activity
REACT:R-HSA-2294590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 binds phosphorylated condensin II complex (Homo sapiens)
REACT:R-XTR-199579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIR2DL4 interacting with HLA-G (Xenopus tropicalis)
RHEA:50377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ceramide(in) + ATP + H2O => a ceramide(out) + ADP + H(+) + phosphate
REACT:R-DME-139854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Drosophila melanogaster)
RHEA:11745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine triphosphate => H(+) + phosphate + thiamine diphosphate
REACT:R-CEL-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Caenorhabditis elegans)
REACT:R-DRE-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Danio rerio)
RHEA:59648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylotriono-1,5-lactone + H2O = D-xylotrionate + H(+)
RHEA:18542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine => dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine
RHEA:64188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-tyrosine + H2O = a fatty acid + L-tyrosine
REACT:R-SSC-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Sus scrofa)
REACT:R-HSA-4719424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates THRB with SUMO1. (Homo sapiens)
REACT:R-GGA-170672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galpha-olf:GTP binds to adenylate cyclase and activates it (Gallus gallus)
RHEA:61215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myricetin + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucoside + UDP
REACT:R-GGA-5357429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL autophosphorylates on Y772 and Y814 (Gallus gallus)
REACT:R-SSC-8849891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs 1-3 bind to PSD-95 family members (Sus scrofa)
REACT:R-HSA-381128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translation of ATF4  (Homo sapiens)
RHEA:16226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-diazacyclotetradecane-2,9-dione + H2O => N-(6-aminohexanoyl)-6-aminohexanoate
REACT:R-DRE-5693533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCLRE1C (ARTEMIS) processes DNA DSB ends (Danio rerio)
RHEA:20981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 bilirubin IXalpha + O2 => 2 biliverdin IXalpha + 2 H2O
RHEA:36664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA => (2S,5S)-5-carboxymethylproline + CO2 + CoA
RHEA:64959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP + 2 H2O <=> dTMP + 2 H(+) + 2 phosphate
REACT:R-DRE-8943040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLTF polyubiquitinates monoubiquitinated PCNA (Danio rerio)
REACT:R-MMU-8866269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB bind GPCRs (Mus musculus)
GO:0031961	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	cortisol receptor binding
GO:0031961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear cortisol receptor binding
RHEA:52157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:67610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+) + N(6)-methyl-AMP => H2O + N(6)-methyl-ATP
RHEA:46397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + H(+) + NADPH => a quinol + NADP(+)
REACT:R-CFA-8981622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin:oxygen dissociates (Canis familiaris)
REACT:R-HSA-9604719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH4 gene transcription is inhibited by RUNX1 (Homo sapiens)
REACT:R-MMU-2161795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Mus musculus)
RHEA:51656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tagaturonate epimerase"
RHEA:51656	skos:altLabel	"tagaturonate/fructuronate epimerase"
RHEA:51656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagaturonate = keto-D-fructuronate
RHEA:51656	skos:altLabel	"fructuronate epimerase"
RHEA:51656	skos:prefLabel	"tagaturonate epimerase"
GO:0102561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 2,5-bisphosphate 2-phosphohydrolase activity
GO:0102561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase"
GO:0102561	skos:altLabel	"cyclic phosphate dihydrolase"
GO:0102561	skos:prefLabel	"phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase"
REACT:R-HSA-8983300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)
RHEA:55900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride + FADH2 + L-tryptophan + O2 = 6-chloro-L-tryptophan + FAD + 2 H2O
REACT:R-BTA-1433488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHP2 by SFKs (Bos taurus)
REACT:R-DRE-6787321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DERA cleaves dR5P to GA3P and CH3CHO (Danio rerio)
RHEA:64206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine
GO:0047852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transferrin reductase activity
GO:0047852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diferric transferrin reductase activity
GO:0047852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diferric-transferrin reductase activity
GO:0047852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transferrin[Fe(II)]2:NAD+ oxidoreductase activity
GO:0047852	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH diferric transferrin reductase activity
REACT:R-HSA-6782943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UV-DDB ubiquitinates XPC (Homo sapiens)
REACT:R-BTA-197958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FPGS-2 transforms THF to THFPG (Bos taurus)
RHEA:41839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-DME-174120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Drosophila melanogaster)
REACT:R-GGA-976768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3b (Gallus gallus)
REACT:R-HSA-5651739	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Homo sapiens)
REACT:R-BTA-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Bos taurus)
RHEA:35918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
RHEA:16442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutaminyl-[protein] => L-glutamyl-[protein] + NH4(+)
REACT:R-DME-389083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PDGF alpha receptors (Drosophila melanogaster)
REACT:R-RNO-112379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of elongation factors to form elongation complex (Rattus norvegicus)
REACT:R-HSA-200879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a Nef:ARF1:CD4 complex (Homo sapiens)
REACT:R-GGA-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Gallus gallus)
GO:0047877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ephedrine dehydrogenase activity
GO:0047877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-ephedrine:NAD+ 2-oxidoreductase activity
RHEA:59774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbopyranose + H2O2 => D-sorbitol + O2
REACT:R-DRE-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Danio rerio)
REACT:R-CFA-376851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Canis familiaris)
RHEA:25545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate => diphosphate + ent-pimara-9(11),15-diene
REACT:R-GGA-9009488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 binds CSF1 (Gallus gallus)
RHEA:36185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline
REACT:R-BTA-2685505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPCN1/2 transport lysosomal Ca2+ to cytosol  (Bos taurus)
RHEA:11107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + hercynine + S-adenosyl-L-homocysteine
RHEA:21032	skos:altLabel	"UDPGA transferase"
RHEA:21032	skos:altLabel	"GT"
RHEA:21032	skos:altLabel	"4-nitrophenol UDPGT"
RHEA:21032	skos:altLabel	"ciramadol UDP-glucuronyltransferase"
RHEA:21032	skos:altLabel	"1-naphthol glucuronyltransferase"
RHEA:21032	skos:altLabel	"UDP glucuronyltransferase"
RHEA:21032	skos:altLabel	"bilirubin glucuronyltransferase"
RHEA:21032	skos:altLabel	"p-nitrophenylglucuronosyltransferase"
RHEA:21032	skos:altLabel	"4-hydroxybiphenyl UDP-glucuronosyltransferase"
RHEA:21032	skos:altLabel	"bilirubin UDP-glucuronosyltransferase"
RHEA:21032	skos:altLabel	"UDPGA-glucuronyltransferase"
RHEA:21032	skos:altLabel	"bilirubin monoglucuronide glucuronyltransferase"
RHEA:21032	skos:altLabel	"uridine diphosphoglucuronate-estriol glucuronosyltransferase"
RHEA:21032	skos:altLabel	"uridine 5'-diphosphoglucuronyltransferase"
RHEA:21032	skos:altLabel	"UDP-glucuronosyltransferase"
RHEA:21032	skos:altLabel	"p-hydroxybiphenyl UDP glucuronyltransferase"
RHEA:21032	skos:altLabel	"p-nitrophenol UDP-glucuronosyltransferase"
RHEA:21032	skos:altLabel	"UDP glucuronate-estradiol-glucuronosyltransferase"
RHEA:21032	skos:altLabel	"uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase"
RHEA:21032	skos:altLabel	"phenyl-UDP-glucuronosyltransferase"
RHEA:21032	skos:altLabel	"UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)"
RHEA:21032	skos:altLabel	"1-naphthol-UDP-glucuronosyltransferase"
RHEA:21032	skos:altLabel	"uridine diphosphoglucuronyltransferase"
RHEA:21032	skos:altLabel	"UDP glucuronic acid transferase"
RHEA:21032	skos:altLabel	"estriol UDPglucuronosyltransferase"
RHEA:21032	skos:altLabel	"17-OH steroid UDPGT"
RHEA:21032	skos:altLabel	"bilirubin uridine diphosphoglucuronyltransferase"
RHEA:21032	skos:altLabel	"4-nitrophenol UDP-glucuronyltransferase"
RHEA:21032	skos:altLabel	"UDP-glucuronate-bilirubin glucuronyltransferase"
RHEA:21032	skos:altLabel	"3alpha-hydroxysteroid UDP-glucuronosyltransferase"
RHEA:21032	skos:altLabel	"uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase"
RHEA:21032	skos:altLabel	"17beta-hydroxysteroid UDP-glucuronosyltransferase"
RHEA:21032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP
RHEA:21032	skos:altLabel	"estrone UDPglucuronosyltransferase"
RHEA:21032	skos:altLabel	"UDP-glucuronyltransferase"
RHEA:21032	skos:altLabel	"uridine diphosphoglucuronate-bilirubin glucuronosyltransferase"
RHEA:21032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronosyltransferase"
RHEA:21032	skos:altLabel	"bilirubin UDPGT"
RHEA:21032	skos:prefLabel	"glucuronosyltransferase"
RHEA:21032	skos:altLabel	"uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase"
RHEA:21032	skos:altLabel	"UDP glucuronate-estriol glucuronosyltransferase"
RHEA:21032	skos:altLabel	"UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase"
RHEA:21032	skos:altLabel	"p-nitrophenol UDP-glucuronyltransferase"
RHEA:21032	skos:altLabel	"uridine diphosphate glucuronyltransferase"
RHEA:21032	skos:altLabel	"uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase"
RHEA:21032	skos:altLabel	"PNP-UDPGT"
RHEA:21032	skos:altLabel	"UDPGT"
RHEA:21032	skos:altLabel	"4-methylumbelliferone UDP-glucuronosyltransferase"
RHEA:21032	skos:altLabel	"3-OH androgenic UDPGT"
RHEA:21032	skos:altLabel	"p-phenylphenol glucuronyltransferase"
RHEA:21032	skos:altLabel	"uridine diphosphoglucuronate-estradiol glucuronosyltransferase"
RHEA:21032	skos:altLabel	"morphine glucuronyltransferase"
RHEA:21032	skos:altLabel	"uridine diphosphoglucuronosyltransferase"
REACT:R-RNO-195287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Rattus norvegicus)
REACT:R-SPO-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Schizosaccharomyces pombe)
REACT:R-DRE-1855163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Danio rerio)
REACT:R-RNO-139899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of BAD protein by 14-3-3 (Rattus norvegicus)
REACT:R-BTA-5693761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA2H hydroxylates CERA (Bos taurus)
REACT:R-CFA-374214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CXCR4 and 7 bind CXCL12 ligand (Canis familiaris)
REACT:R-HSA-9023132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates MECP2 at S423 (Homo sapiens)
REACT:R-MMU-193072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)
RHEA:16292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,2S)-ephedrine + NAD(+) <=> (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH
REACT:R-DDI-8982026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q):RGS dissociates to inactive G alpha (q) (Dictyostelium discoideum)
RHEA:47985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + presqualene diphosphate => diphosphate + hydroxysqualene
REACT:R-DME-400071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Drosophila melanogaster)
REACT:R-CFA-5626953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds DENN/MADD (Canis familiaris)
RHEA:26161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => thalianol
REACT:R-MMU-1181153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Mus musculus)
REACT:R-XTR-5624954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INPP5E translocates to the primary cilium (Xenopus tropicalis)
RHEA:56869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA
RHEA:16014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly)
RHEA:24841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine
REACT:R-SSC-72095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internal Methylation of mRNA (Sus scrofa)
REACT:R-DME-2744242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH2/3 transport cytosolic Cl- to extracellular region (Drosophila melanogaster)
REACT:R-RNO-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Rattus norvegicus)
REACT:R-SSC-2065549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Sus scrofa)
RHEA:25984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-BTA-6804955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDM2 (Bos taurus)
REACT:R-CEL-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Caenorhabditis elegans)
RHEA:33279	skos:prefLabel	"tryptophan N-monooxygenase"
RHEA:33279	skos:altLabel	"CYP79B1"
RHEA:33279	skos:altLabel	"CYP79B3"
RHEA:33279	skos:altLabel	"CYP79B2"
RHEA:33279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
RHEA:33279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tryptophan N-monooxygenase"
RHEA:33279	skos:altLabel	"tryptophan N-hydroxylase"
REACT:R-SSC-5687088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates MAPKAPK5 (Sus scrofa)
REACT:R-DME-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Drosophila melanogaster)
REACT:R-RNO-392751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 linked to actin cytoskeleton by ankyrin (Rattus norvegicus)
REACT:R-DME-6809707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR12 binds MTMR2 (Drosophila melanogaster)
REACT:R-BTA-166038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-bound CD14 binds LPS (Bos taurus)
RHEA:42635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine
REACT:R-MMU-215526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F3 20-hydroxylates LTB4 (Mus musculus)
REACT:R-BTA-5696448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Bos taurus)
RHEA:57827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + adenine
REACT:R-SSC-354060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of RIAM to plasma membrane (Sus scrofa)
REACT:R-GGA-372425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)
REACT:R-CEL-187934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)
RHEA:31475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol B + UDP-alpha-D-glucuronate = H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP
REACT:R-GGA-417842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 receptor can bind to LPA (Gallus gallus)
RHEA:39002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine
REACT:R-CFA-451347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JNK by DSCAM (Canis familiaris)
REACT:R-GGA-4641205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPO:LGR binds ZNRF3 (Gallus gallus)
RHEA:34249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH => 1-deoxymethyl-sphinganine + NADP(+)
REACT:R-BTA-446684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Bos taurus)
REACT:R-SPO-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Schizosaccharomyces pombe)
REACT:R-HSA-112282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK4 enters the nucleus (Homo sapiens)
RHEA:61855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesterol + UDP-alpha-D-glucose <=> campesteryl 3-beta-D-glucoside + H(+) + UDP
REACT:R-HSA-446364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Migfilin interacts with VASP (Homo sapiens)
RHEA:34169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+) => 2,6-dihydroxypseudooxynicotine + H2O
REACT:R-BTA-5686704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ATM phosphorylates DCLRE1C (Bos taurus)
RHEA:14552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + formate + H(+)
REACT:R-RNO-173488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
REACT:R-MMU-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Mus musculus)
REACT:R-XTR-6790038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HSP90B1 (Xenopus tropicalis)
RHEA:16264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[protein] + succinyl-CoA <=> CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]
RHEA:36741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosanoyl-CoA
REACT:R-HSA-200676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Homo sapiens)
REACT:R-CFA-8963915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D binds VDR (Canis familiaris)
RHEA:70291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-aminophenyl)-3-oxopropanal = H2O + quinolin-4-ol
RHEA:71371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	epitestosterone 17-sulfate(out) + 2 Na(+)(out) = epitestosterone 17-sulfate(in) + 2 Na(+)(in)
REACT:R-HSA-110322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Pol zeta complex (Homo sapiens)
REACT:R-DRE-5682794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI1 binds ADAM22 and ADAM23 (Danio rerio)
RHEA:54825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] => alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)
REACT:R-XTR-2187330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
RHEA:37125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine => sphing-4-enine + tetracosenoyl-CoA
RHEA:29654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine(in) + L-arginine(out) <=> agmatine(out) + L-arginine(in)
REACT:R-HSA-3247837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT ligands traffic to the Golgi (Homo sapiens)
REACT:R-CEL-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Caenorhabditis elegans)
REACT:R-MMU-8858270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HILPDA binds lipid droplets (Mus musculus)
REACT:R-HSA-5358912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 exchanges ADP for ATP (Homo sapiens)
REACT:R-RNO-9706390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds interacting proteins at trans-Golgi network (Rattus norvegicus)
GO:0098640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	integrin binding involved in cell-matrix adhesion
REACT:R-HSA-2029273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds to p-6Y-SYK (Homo sapiens)
REACT:R-BTA-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Bos taurus)
RHEA:25506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-phellandrene + diphosphate => (2E)-geranyl diphosphate
REACT:R-HSA-9701529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Homo sapiens)
REACT:R-BTA-6805276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates TP53 (Bos taurus)
REACT:R-SPO-947591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Schizosaccharomyces pombe)
REACT:R-DRE-446083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD151 interacts with BP180 and the integrin alpha 6 subunit (Danio rerio)
REACT:R-RNO-549322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations out of hepatic cells (Rattus norvegicus)
RHEA:59259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-enterobactin + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)
REACT:R-RNO-8983307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL15RA (Rattus norvegicus)
REACT:R-BTA-210444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamate loading of synaptic vesicle (Bos taurus)
REACT:R-HSA-2465971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RLBP1 binds atROL to form RLBP1:atROL (Homo sapiens)
REACT:R-HSA-9759202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)
REACT:R-DRE-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Danio rerio)
GO:0033950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xyloglucan-specific exo-beta-1,4-glucanase activity
GO:0033950	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity
GO:0033950	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Cel74A
REACT:R-RNO-5696605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP12, USP26 deubiquitinate AR (Rattus norvegicus)
RHEA:16047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose
RHEA:53657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 => (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate
REACT:R-HSA-2213239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MHC II alpha beta heterodimer (Homo sapiens)
RHEA:49289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)
RHEA:43762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12] => acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12]
REACT:R-HSA-388829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 phosphatase binds CTLA-4 (Homo sapiens)
RHEA:44690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + glycerol + H(+) => a 2-acylglycerol + H2O
REACT:R-RNO-1467269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins bind microbial membranes causing disruption (Rattus norvegicus)
RHEA:55074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + propanal => 2-oxobutanoate + H(+)
REACT:R-DDI-5696424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Dictyostelium discoideum)
GO:0106343	skos:prefLabel	"glutarate dioxygenase"
GO:0106343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutarate dioxygenase"
GO:0106343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate dioxygenase activity
GO:0106343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate
RHEA:10989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nitrous oxide => 2 e(-) + 2 H(+) + 2 nitric oxide
RHEA:39183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodocosanoyl-CoA + H(+) + NADPH = (3R)-hydroxydocosanoyl-CoA + NADP(+)
RHEA:12945	skos:altLabel	"2-(2-hydroxyphenyl)benzenesulfinate hydrolase"
RHEA:12945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-hydroxybiphenyl-2-sulfinate desulfinase"
RHEA:12945	skos:altLabel	"2-(2-hydroxyphenyl)benzenesulfinate desulfinase"
RHEA:12945	skos:altLabel	"2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase"
RHEA:12945	skos:prefLabel	"2'-hydroxybiphenyl-2-sulfinate desulfinase"
RHEA:12945	skos:altLabel	"2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase"
RHEA:12945	skos:altLabel	"HPBS desulfinase"
RHEA:12945	skos:altLabel	"HBPSi desulfinase"
RHEA:12945	skos:altLabel	"2-(2'-hydroxyphenyl)benzenesulfinate desulfinase"
RHEA:12945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + H(+) + sulfite
RHEA:12945	skos:altLabel	"dibenzothiophene desulfurization enzyme B"
REACT:R-HSA-9008587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37, IL37(?-218) binds IL18BP (Homo sapiens)
REACT:R-DRE-2197690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detachment of WASP/WAVE (Danio rerio)
RHEA:71618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(in) + sulfate(out) <=> (S)-malate(out) + sulfate(in)
RHEA:41805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxobutanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxybutanoyl-[ACP] + NADP(+)
REACT:R-BTA-2514867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Bos taurus)
RHEA:28361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + FADH2
REACT:R-DRE-1250353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Danio rerio)
REACT:R-CFA-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Canis familiaris)
REACT:R-BTA-977619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Bos taurus)
RHEA:12755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone + H(+) + NADPH => glycerol + NADP(+)
REACT:R-CEL-5669240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLNA binds PAK1 (Caenorhabditis elegans)
REACT:R-SSC-209910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Iodide is taken up by thyroid epithelial cells (Sus scrofa)
RHEA:17265	skos:altLabel	"aconitate isomerase"
RHEA:17265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-aconitate = cis-aconitate
RHEA:17265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aconitate Delta-isomerase"
RHEA:17265	skos:prefLabel	"aconitate Delta-isomerase"
RHEA:13399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexanedioate + NADPH => 6-oxohexanoate + H2O + NADP(+)
REACT:R-CFA-5654510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 binds SPRED1/2 (Canis familiaris)
REACT:R-BTA-5683405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP5C dephosphorylates TP53BP1 (Bos taurus)
RHEA:43195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine
RHEA:66432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-galactose(out) = H(+)(in) + L-galactose(in)
REACT:R-GGA-5635864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH ubiquitinates GLI1 (Gallus gallus)
RHEA:27743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + adenine
RHEA:54919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-cis-retinol + NADP(+) <=> 9-cis-retinal + H(+) + NADPH
RHEA:48762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-erythrulose + NADH => L-threitol + NAD(+)
REACT:R-MMU-549192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Mus musculus)
REACT:R-XTR-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Xenopus tropicalis)
REACT:R-DRE-8952062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 recruits HDAC4 to RUNX3 (Danio rerio)
GO:0022832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated channel activity
RHEA:41448	skos:prefLabel	"L-isoleucine 4-hydroxylase"
RHEA:41448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-isoleucine + O2 = (4S)-4-hydroxy-L-isoleucine + CO2 + succinate
RHEA:41448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-isoleucine 4-hydroxylase"
GO:0016633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GLDHase activity
GO:0016633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-galactonolactone dehydrogenase activity
GO:0016633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-galactono-1,4-lactone dehydrogenase activity
GO:0016633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GLDase activity
GO:0016633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity
GO:0016633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-galactono-gamma-lactone dehydrogenase activity
GO:0016633	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity
GO:0016633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactonolactone dehydrogenase activity
REACT:R-SPO-3371590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP70 binds to HSP40:nascent protein (Schizosaccharomyces pombe)
RHEA:52514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+) => a quinone + trans-4-hydroxy-L-proline
GO:0004098	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arylsulfatase A activity
GO:0004098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cerebroside-sulfatase"
GO:0004098	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cerebroside-3-sulfate 3-sulfohydrolase activity
GO:0004098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cerebroside-sulfatase activity
GO:0004098	skos:altLabel	"arylsulfatase A"
GO:0004098	skos:prefLabel	"cerebroside-sulfatase"
GO:0004098	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cerebroside sulfate sulfatase activity
GO:0004098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate
GO:0004098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cerebroside-sulphatase activity
REACT:R-DRE-8849908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM4 binds flotillin-1 (Danio rerio)
RHEA:17771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0106018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,5-bisphosphate phosphatase activity
RHEA:61659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + ATP <=> (2E,6E)-farnesyl phosphate + ADP + H(+)
RHEA:21752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-violaxanthin = all-trans-capsorubin
REACT:R-RNO-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Rattus norvegicus)
RHEA:18642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinone + H2 => a menaquinol
RHEA:62097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-glycerol + phosphate
RHEA:18186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + O2 => 5'-dehydroadenosine + H2O2
RHEA:57620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]
RHEA:48405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aryl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]
RHEA:38140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
RHEA:43857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)
RHEA:50659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O
RHEA:11620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-2-amino-4-chloropent-4-enoate = 2-oxopent-4-enoate + chloride + H(+) + NH4(+)
RHEA:11620	skos:prefLabel	"L-2-amino-4-chloropent-4-enoate dehydrochlorinase"
RHEA:11620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-2-amino-4-chloropent-4-enoate dehydrochlorinase"
REACT:R-XTR-156723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Regulation of KIF20A (MKL2) by phosphorylation (Xenopus tropicalis)
REACT:R-MMU-2453863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRA6 transports atROL from extracellular region to cytosol (Mus musculus)
REACT:R-GGA-212706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospholipase C-gamma1 binds to the activated EGF receptor (Gallus gallus)
REACT:R-MMU-158942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Mus musculus)
REACT:R-GGA-426015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at trans-golgi membrane) (Gallus gallus)
REACT:R-XTR-6788912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHPP:Mg2+ dimer hydrolyses PPi (Xenopus tropicalis)
REACT:R-XTR-629588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Xenopus tropicalis)
GO:0008937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferredoxin-NAD(P) reductase activity
GO:0008937	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ferredoxin reductase activity
GO:0050032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnonate dehydratase activity
GO:0050032	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)
GO:0050032	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-rhamnonate hydro-lyase activity
RHEA:60164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a guanosine in RNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine
REACT:R-RNO-166753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C4 into C4a and C4b (Rattus norvegicus)
REACT:R-XTR-6803789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Xenopus tropicalis)
RHEA:10087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + O2 <=> 3-carboxy-cis,cis-muconate + 2 H(+)
REACT:R-HSA-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Homo sapiens)
RHEA:69045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrobutanedioate => fumarate + H(+) + nitrite
RHEA:52607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)
RHEA:28608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-9023846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive CTSD expression (Homo sapiens)
REACT:R-GGA-5687675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3 ligates remaining SSBs in MMEJ (Gallus gallus)
REACT:R-DRE-266082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)
EC:1.7.9.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a copper protein as acceptor"
EC:1.7.9.-	skos:prefLabel	"With a copper protein as acceptor"
REACT:R-SSC-1474197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP1,3,8,13,PRSS2 (Sus scrofa)
REACT:R-SSC-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Sus scrofa)
REACT:R-BTA-9704151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM1,3,5 bind CHRM1,3,5 antagonists (Bos taurus)
RHEA:16688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,poly-cis-dolichol + hexadecanoyl-CoA <=> a dolichyl hexadecanoate + CoA
RHEA:42215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
REACT:R-RNO-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
REACT:R-SSC-112435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin BC complex (Sus scrofa)
REACT:R-MMU-70454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Mus musculus)
RHEA:53758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allodeoxycholate + choloyl-CoA => allodeoxycholoyl-CoA + cholate
RHEA:24768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + H(+) + NADH
REACT:R-BTA-8984014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Bos taurus)
RHEA:50934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2
RHEA:63608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apelin-17 + H2O = apelin-16 + L-phenylalanine
REACT:R-DME-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Drosophila melanogaster)
REACT:R-DRE-8985343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds SOX9 (Danio rerio)
REACT:R-RNO-265010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)
REACT:R-DDI-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Dictyostelium discoideum)
RHEA:22641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sphinganine => 3-oxosphinganine + H(+) + NADPH
REACT:R-XTR-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Xenopus tropicalis)
RHEA:35541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albonoursin + H2O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2
RHEA:49970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-BTA-1971487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHSY3 transfer GalNAc to chondroitin (Bos taurus)
RHEA:44879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,3-diacylglycerol + H2O <=> 3-acyl-sn-glycerol + a fatty acid + H(+)
REACT:R-DDI-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Dictyostelium discoideum)
REACT:R-HSA-9665699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)
RHEA:33806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidinal + NAD(+) <=> 2 H(+) + L-histidine + NADH
REACT:R-HSA-2129357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin C-terminal processing (Homo sapiens)
RHEA:65742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H(+) + nonanal + succinate + sulfate => 2-oxoglutarate + nonyl sufate + O2
REACT:R-BTA-429860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCP1-DCP2 complex decaps mRNA (Bos taurus)
REACT:R-RNO-6798749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule lumen proteins (Rattus norvegicus)
RHEA:48026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dipropanoylglycerol + H(+) + propanoate => 1,2,3-tripropanoylglycerol + H2O
REACT:R-CFA-191352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCR dimer reduces bHMG-CoA to MVA (Canis familiaris)
RHEA:67311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one
REACT:R-HSA-74718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalisation of the insulin receptor (Homo sapiens)
REACT:R-BTA-9701055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)
REACT:R-MMU-9716913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1 binds ESR1 antagonists (Mus musculus)
REACT:R-XTR-4615987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates HDAC4 with SUMO2,3 (Xenopus tropicalis)
RHEA:10607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine
EC:3.4.14.1	skos:altLabel	"dipeptidyl transferase"
EC:3.4.14.1	skos:altLabel	"dipeptidyl aminopeptidase I"
EC:3.4.14.1	skos:prefLabel	"dipeptidyl-peptidase I"
EC:3.4.14.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dipeptidyl-peptidase I"
EC:3.4.14.1	skos:altLabel	"cathepsin J"
EC:3.4.14.1	skos:altLabel	"cathepsin C"
REACT:R-HSA-194818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botA LC cleaves target cell SNAP25 (Homo sapiens)
REACT:R-RNO-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Rattus norvegicus)
REACT:R-MMU-3371359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Mus musculus)
REACT:R-RNO-354165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
RHEA:42103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamoyl phosphate + H2O + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate
GO:0034593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidyl-inositol-bisphosphate phosphatase activity
GO:0034593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol bisphosphate phosphatase activity
GO:0034593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triphosphoinositide phosphomonoesterase activity
GO:0034593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	triphosphoinositide phosphatase activity
GO:0034593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphoinositide phosphatase activity
GO:0034593	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylinositol-bisphosphatase activity
REACT:R-DRE-9647999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RCE1 cleaves S-Farn proRAS proteins (Danio rerio)
REACT:R-HSA-9669854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIT binds type II TKIs (Homo sapiens)
RHEA:54367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetaldehyde <=> acetoin
REACT:R-DDI-109955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ERCC1:XPF heterodimeric complex (Dictyostelium discoideum)
REACT:R-SPO-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Schizosaccharomyces pombe)
REACT:R-SSC-2429719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCPH1 sequesters condensin II (Sus scrofa)
GO:0008465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH
GO:0008465	skos:altLabel	"hydroxypyruvate dehydrogenase"
GO:0008465	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydroxypyruvate dehydrogenase activity
GO:0008465	skos:prefLabel	"glycerate dehydrogenase"
GO:0008465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerate dehydrogenase activity
GO:0008465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerate dehydrogenase"
GO:0008465	skos:altLabel	"D-glycerate dehydrogenase"
GO:0062072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H3K9me3 modified histone binding
REACT:R-BTA-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Bos taurus)
REACT:R-CEL-1964505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Caenorhabditis elegans)
RHEA:54198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine
RHEA:45836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:62012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:20464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine
RHEA:34504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (+)-epi-alpha-bisabolol + diphosphate
RHEA:20545	skos:prefLabel	"kynurenine 3-monooxygenase"
RHEA:20545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)
RHEA:20545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kynurenine 3-monooxygenase"
RHEA:20545	skos:altLabel	"kynurenine 3-hydroxylase"
REACT:R-RNO-3229089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Rattus norvegicus)
REACT:R-HSA-3159253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMAB adenosylates cob(I)alamin (Homo sapiens)
REACT:R-CFA-158721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Canis familiaris)
RHEA:17210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O => 2-formylglutarate + NH4(+)
RHEA:43377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyinosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
REACT:R-HSA-202443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of CARMA1 (Homo sapiens)
REACT:R-HSA-83586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Homo sapiens)
GO:1990593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACA binding
GO:1990593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent polypeptide-associated complex binding
GO:1990593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAC binding
RHEA:18393	skos:altLabel	"beta-aminoisobutyrate-pyruvate aminotransferase"
RHEA:18393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
RHEA:18393	skos:altLabel	"beta-aminoisobutyrate--pyruvate aminotransferase"
RHEA:18393	skos:altLabel	"D-AIBAT"
RHEA:18393	skos:altLabel	"D-beta-aminoisobutyrate:pyruvate aminotransferase"
RHEA:18393	skos:altLabel	"(R)-3-amino-2-methylpropionate--pyruvate aminotransferase"
RHEA:18393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-3-amino-2-methylpropionate--pyruvate transaminase"
RHEA:18393	skos:altLabel	"(R)-3-amino-2-methylpropionate transaminase"
RHEA:18393	skos:altLabel	"D-3-aminoisobutyrate-pyruvate aminotransferase"
RHEA:18393	skos:altLabel	"D-3-aminoisobutyrate-pyruvate transaminase"
RHEA:18393	skos:prefLabel	"(R)-3-amino-2-methylpropionate--pyruvate transaminase"
RHEA:18393	skos:altLabel	"beta-aminoisobutyrate--pyruvate transaminase"
RHEA:18393	skos:altLabel	"D-3-aminoisobutyrate--pyruvate transaminase"
GO:0044610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	flavine mononucleotide transmembrane transporter activity
GO:0044610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN transmembrane transporter activity
RHEA:36226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine
RHEA:14933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate
REACT:R-BTA-5689000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Bos taurus)
RHEA:41543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine
REACT:R-GGA-372726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate [mitochondrial matrix] + glutamate [cytosol] <=> aspartate [cytosol] + glutamate [mitochondrial matrix] (Gallus gallus)
REACT:R-MMU-174159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Emi1 by SCF-beta-TrCP (Mus musculus)
REACT:R-XTR-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Xenopus tropicalis)
REACT:R-CEL-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Caenorhabditis elegans)
RHEA:39159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O
RHEA:43688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate = L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate
REACT:R-CEL-429749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A8 transports monocarboxylates from extracellular region to cytosol (Caenorhabditis elegans)
GO:0010313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytochrome binding
RHEA:30144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoyl-CoA => CoA + H(+) + octanoate
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerate phosphomutase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-phospho-D-glycerate 1,2-phosphomutase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	bisphosphoglyceromutase
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	biphosphoglycerate synthase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisphosphoglycerate mutase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-bisphosphoglycerate synthase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-bisphosphoglycerate mutase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphoglycerate mutase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-diphosphoglycerate mutase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BPGM activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-diphosphoglyceromutase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphoglyceromutase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bisphosphoglycerate synthase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diphosphoglyceric mutase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-diphosphoglycerate synthase activity
GO:0004082	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	DPGM
RHEA:51031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> 7-chloroindole-3-pyruvate imine dimer + 2 H2O
REACT:R-CFA-3209165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ID1 sequesters ETS2 (Canis familiaris)
REACT:R-HSA-1676124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Homo sapiens)
REACT:R-SSC-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Sus scrofa)
RHEA:10218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phospho-[DNA-directed RNA polymerase] => [DNA-directed RNA polymerase] + ATP
RHEA:14139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine
RHEA:29931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)
REACT:R-BTA-9679044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds sirolimus (Bos taurus)
RHEA:18779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alkane + Hg(2+) => an alkylmercury + H(+)
RHEA:51865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + esculetin => 8-geranylesculetin + diphosphate
RHEA:56540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA
RHEA:37052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-RNO-629595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)
REACT:R-XTR-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Xenopus tropicalis)
RHEA:10337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate => D-threo-isocitrate
RHEA:25367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) = H(+) + momilactone A + NADPH
REACT:R-CFA-2022911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSPG is secreted (Canis familiaris)
RHEA:32911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphocholine(out) = sn-glycerol 3-phosphocholine(in)
REACT:R-SCE-1855213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Saccharomyces cerevisiae)
REACT:R-HSA-5617887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HOXC4 chromatin is activated (Homo sapiens)
RHEA:44280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA
REACT:R-SSC-909729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JAK kinases (Sus scrofa)
RHEA:43109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + N2 => 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide
REACT:R-BTA-5654664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS binds GRB2:SOS1 (Bos taurus)
REACT:R-SPO-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Schizosaccharomyces pombe)
RHEA:59977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylacetate + H(+) => CO2 + toluene
REACT:R-RNO-2028673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Rattus norvegicus)
REACT:R-DRE-190260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2b binds to FGF (Danio rerio)
GO:0102246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-amino-6-deoxyfutalosine hydrolase activity
REACT:R-CEL-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Caenorhabditis elegans)
RHEA:18491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamate + CO2 => cyanate + H(+) + hydrogencarbonate
RHEA:52111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
RHEA:23559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine + L-glutamine <=> gamma-L-glutamyl-D-alanine + NH4(+)
REACT:R-SSC-6809014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-Golgi cis-SNARE binds NSF and SNAPs (Sus scrofa)
REACT:R-MMU-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Mus musculus)
RHEA:19827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate
GO:0001002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:0001002	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase III type 1 promoter DNA binding
REACT:R-CFA-170666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
RHEA:39697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+) => 3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH
REACT:R-GGA-2203516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-1-Microglobulin is cleaved (Gallus gallus)
GO:0046935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol 3-kinase regulator activity
GO:0046935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol-3-kinase regulator activity
GO:0046935	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	phosphatidylinositol 3-kinase, class I, regulator activity
RHEA:50904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine
REACT:R-XTR-193424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
REACT:R-HSA-6809521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BPIF binds bacteria (Homo sapiens)
REACT:R-BTA-880002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Bos taurus)
REACT:R-DME-71046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Drosophila melanogaster)
RHEA:45676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
REACT:R-SCE-71200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)
REACT:R-GGA-5252001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP1B4 binds SNW1 (Gallus gallus)
REACT:R-HSA-936960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Homo sapiens)
REACT:R-SPO-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Schizosaccharomyces pombe)
REACT:R-CFA-1964496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds TRIM32 or TRIM56  (Canis familiaris)
RHEA:24157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoate + ATP => 2-methylpropanoyl phosphate + ADP
REACT:R-HSA-1483218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG transports from the ER membrane to the late endosome membrane (Homo sapiens)
REACT:R-GGA-1299338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TRESK (Gallus gallus)
REACT:R-HSA-73564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer decarboxylates OMP to UMP (Homo sapiens)
RHEA:45451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(dodecanoyl)-sphinganine <=> dodecanoate + sphinganine
RHEA:31204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + hexanoyl-CoA => 3-oxooctanoyl-CoA + CoA
GO:0004112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-nucleotide phosphodiesterase activity
REACT:R-DME-6811415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB:GTP recruits GBF1 to the Golgi membrane (Drosophila melanogaster)
RHEA:66312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-mannosylinositol-1-phosphoceramide + H2O = a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)
REACT:R-SSC-5336182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR37 binds prosaptide (Sus scrofa)
RHEA:66725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + L-phenylalanine => H2O + N-[(S)-lactoyl]-L-phenylalanine
REACT:R-MMU-9009558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds SDC1 (Mus musculus)
REACT:R-MMU-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Mus musculus)
RHEA:70413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + CoA + H(+) => 4-hydroxyphenylacetyl-CoA + H2O
REACT:R-CFA-1363276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p130 (RBL2) by PP2A (Canis familiaris)
REACT:R-GGA-420233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VIP receptors bind VIP (Gallus gallus)
REACT:R-BTA-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Bos taurus)
RHEA:49974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-9012000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Homo sapiens)
REACT:R-CFA-5631903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,2,3 bind overoxidized PRDX1 (Canis familiaris)
REACT:R-DME-163733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of FAS monomer gene by ChREBP:MLX (Drosophila melanogaster)
REACT:R-MMU-6804242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the complex of JMY, EP300 and TTC5 (Mus musculus)
RHEA:47500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NADP(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH
RHEA:59952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+)
RHEA:25924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-8-ol = 8-hydroxyquinolin-2(1H)-one + AH2
REACT:R-GGA-353226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Ku heterodimer with ends of DNA double-strand breaks (Gallus gallus)
RHEA:16318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-indan-1-ol + NAD(+) => H(+) + indan-1-one + NADH
REACT:R-SSC-390427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Sus scrofa)
REACT:R-HSA-8853965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Homo sapiens)
RHEA:18019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + indole-3-acetaldehyde => H(+) + indole-3-pyruvate
REACT:R-RNO-9640168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Rattus norvegicus)
RHEA:48520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol
RHEA:48520	skos:altLabel	"prenylcysteine methylesterase"
RHEA:48520	skos:prefLabel	"protein-S-isoprenylcysteine alpha-carbonyl methylesterase"
RHEA:48520	skos:altLabel	"isoprenylcysteine methylesterase"
RHEA:48520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-S-isoprenylcysteine alpha-carbonyl methylesterase"
REACT:R-SSC-392530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S400-Cot phosphorylates NIK (Sus scrofa)
REACT:R-XTR-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Xenopus tropicalis)
REACT:R-RNO-378513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Rattus norvegicus)
GO:0004399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidinol dehydrogenase activity
GO:0052609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-ketotorulene 3-hydroxylase activity
GO:0052609	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-ring carotenoid 3-hydroxylase activity
GO:0052609	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	carotene beta-ring hydroxylase activity
GO:0052609	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	beta-carotene hydroxylase activity
REACT:R-HSA-2161917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 15S-HpETE to LXA4/B4 (Homo sapiens)
REACT:R-MMU-2162002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Mus musculus)
REACT:R-XTR-389354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Vav1 (Xenopus tropicalis)
REACT:R-XTR-1855176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Xenopus tropicalis)
REACT:R-GGA-177275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates DARPP-32 on Thr34 (Gallus gallus)
RHEA:69142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + putrescine => N-(4-aminobutyl)-3-aminopropanal
REACT:R-BTA-140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor V -> factor Va + factor V activation peptide (Bos taurus)
REACT:R-SSC-9009554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer:SDC1 binds CSF1R (Sus scrofa)
RHEA:43084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:16371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + pyruvate => (R)-lactate + NAD(+)
RHEA:71312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-alanine(out) + 2 Na(+)(out) => chloride(in) + L-alanine(in) + 2 Na(+)(in)
RHEA:32584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocarvone + H(+) + NADPH + O2 => 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)
REACT:R-CFA-2065355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)
GO:0035446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
GO:0035446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	MshC ligase
GO:0035446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-glucosaminylinositol ligase activity
GO:0035446	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desacetylmycothiol synthase
REACT:R-DRE-9668831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CST complex formation (Danio rerio)
REACT:R-HSA-5617828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIP11:IFT20 dissociates (Homo sapiens)
RHEA:62838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
RHEA:71977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(in) + 3 Na(+)(in) => glutathione(out) + 3 Na(+)(out)
REACT:R-HSA-5654416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:pFRS binds GRB2:SOS1 (Homo sapiens)
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1beta-MGDG
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose:diacylglycerol galactosyltransferase activity
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacylglycerol 3-beta-galactosyltransferase activity
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-beta-MGDG activity
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MGDG synthase activity
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP galactose-1,2-diacylglycerol galactosyltransferase activity
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	monogalactosyldiacylglycerol synthase activity
GO:0046509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-galactose-diacylglyceride galactosyltransferase activity
RHEA:71040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(in) + L-phenylalanine(out) => L-methionine(out) + L-phenylalanine(in)
RHEA:62521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in rRNA + S-adenosyl-L-methionine => an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-350578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NQO1 interaction with ODC (Canis familiaris)
RHEA:63044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + mevastatin = H(+) + mevinic carboxylate
REACT:R-CFA-1678998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endosomal TLRs pass through the Golgi (Canis familiaris)
REACT:R-PFA-482804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Plasmodium falciparum)
REACT:R-DME-5654677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR2 (Drosophila melanogaster)
RHEA:48115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
RHEA:14280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactaldehyde + H2O + NAD(+) <=> (S)-lactate + 2 H(+) + NADH
REACT:R-SSC-1181149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Sus scrofa)
RHEA:39625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH
REACT:R-CFA-8876188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND4s exchange GTP for GDP on RAB10 (Canis familiaris)
REACT:R-RNO-8848663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADIPOQ trimer binds ADIPOR dimers (Rattus norvegicus)
REACT:R-CFA-1067640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R-2 (Canis familiaris)
RHEA:60438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol + acetate + H(+) => 3-methylbutyl acetate + H2O
REACT:R-MMU-71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer reduces PYR to LACT (Mus musculus)
REACT:R-CEL-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Caenorhabditis elegans)
RHEA:31656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine
RHEA:54996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-MMU-3165230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC52A1,2,3 transport RIB from extracellular region to cytosol (Mus musculus)
REACT:R-HSA-9645406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Homo sapiens)
REACT:R-CFA-9023617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrylcholinesterase hydrolyzes acyl Ghrelin (Canis familiaris)
REACT:R-CEL-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)
REACT:R-XTR-6809393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin filaments bind cell-cell adhesion complexes (Xenopus tropicalis)
REACT:R-HSA-1234159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
REACT:R-SSC-452036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine + H2O => ornithine + urea [ARG2] (Sus scrofa)
REACT:R-SSC-432164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Sus scrofa)
RHEA:36836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-CFA-6801776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A binds bacterial phospholipids (Canis familiaris)
REACT:R-SPO-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Schizosaccharomyces pombe)
REACT:R-SSC-1483063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG and CDP-DAG are converted to CL by CRLS1 (Sus scrofa)
REACT:R-CEL-1676145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Caenorhabditis elegans)
REACT:R-MMU-379426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Mus musculus)
RHEA:63988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-thiocytidine + ATP = 2-thiocytidine 5'-phosphate + ADP + H(+)
RHEA:18091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-citrullyl-[protein] + NH4(+) => H2O + L-arginyl-[protein]
REACT:R-DDI-1482892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Dictyostelium discoideum)
REACT:R-DRE-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Danio rerio)
REACT:R-CEL-77333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Caenorhabditis elegans)
REACT:R-BTA-6810937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lamellar bodies bind the early cornified envelope (Bos taurus)
RHEA:70705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cycloserine(out) + H(+)(out) => D-cycloserine(in) + H(+)(in)
REACT:R-HSA-170026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protons are translocated from the intermembrane space to the matrix (Homo sapiens)
GO:0047818	skos:prefLabel	"D-fuconate dehydratase"
GO:0047818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-fuconate dehydratase"
GO:0047818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)
GO:0047818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fuconate hydro-lyase activity
GO:0047818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O
GO:0047818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fuconate hydratase activity
GO:0047818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fuconate dehydratase activity
RHEA:10319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + thymine <=> 5-hydroxymethyluracil + CO2 + succinate
REACT:R-CEL-74241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADA catalyzes the deamination of (deoxy)adenosine (Caenorhabditis elegans)
REACT:R-SSC-426522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nonendonucleolytic RISC binds exactly matching target RNAs (Sus scrofa)
RHEA:57990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose
REACT:R-CFA-159443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Canis familiaris)
REACT:R-RNO-1971483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Rattus norvegicus)
REACT:R-XTR-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Xenopus tropicalis)
RHEA:24261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E)-2-oxohex-3-enedioate + H(+) => 2-oxopent-4-enoate + CO2
RHEA:61927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,4R)-ketoconazole(in) + ATP + H2O <=> (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate
REACT:R-CEL-5676637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Caenorhabditis elegans)
RHEA:69136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 O2 + spermine = 2 H2O2 + 2 NH4(+) + spermine dialdehyde
RHEA:38901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out)
REACT:R-SSC-74707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of IRS to insulin receptor (Sus scrofa)
RHEA:28395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanyl-L-glutamate => L-alanyl-D-glutamate
RHEA:13543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + sulfate + sulfur + thiosulfate => H2O + tetrathionate
REACT:R-DRE-383373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 3 (NK3) binds to neurokinin B (Danio rerio)
RHEA:12219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9H-fluoren-9-ol + NAD(+) <=> 9H-fluoren-9-one + H(+) + NADH
RHEA:59659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotriose + O2 <=> D-cellotriono-1,5-lactone + H2O2
GO:0043757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CbiB
GO:0043757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)
GO:0043757	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AdoCbi-P synthase activity
GO:0043757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcobinamide-phosphate synthase activity
REACT:R-DRE-9708859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Danio rerio)
REACT:R-SPO-8986181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Schizosaccharomyces pombe)
RHEA:13859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + D-glucose + H(+) => a dolichyl beta-D-glucosyl phosphate + H2O
GO:0018445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prothoracicotrophic hormone activity
REACT:R-SSC-380294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of C-Nap-1 from centrosomes (Sus scrofa)
REACT:R-BTA-392513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rap1 signal termination by Rap1GAPs (Bos taurus)
RHEA:65866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-1,3,17-trione + AH2 => 5alpha-androst-1-ene-3,17-dione + A + H2O
RHEA:44925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoadipate + acetyl-CoA + H2O => (R)-dihomocitrate + CoA + H(+)
RHEA:36554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol <=> 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)
REACT:R-HSA-2187395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylated SMAD2/3 translocates to the cytosol (Homo sapiens)
REACT:R-RNO-6799332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATR phosphorylates TP53 (Rattus norvegicus)
REACT:R-MMU-9693111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOF auto-activates (Mus musculus)
REACT:R-MMU-8985988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Mus musculus)
RHEA:42019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cortisone + NAD(+) <=> 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH
REACT:R-GGA-6803545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP7A transports cytosolic Cu2+ to phagosomal lumen (Gallus gallus)
REACT:R-BTA-2022411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)
GO:0050089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannose ketol-isomerase activity
GO:0050089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannose isomerase activity
GO:0050089	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-mannose aldose-ketose-isomerase activity
GO:0050089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannose isomerase activity
REACT:R-HSA-9646354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded Proteins:HDAC6 dissociate from complex (Homo sapiens)
EC:1.14.13.179	skos:prefLabel	"methylxanthine N(3)-demethylase"
EC:1.14.13.179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylxanthine N(3)-demethylase"
REACT:R-CFA-5099886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binding to FZD promotes PRICKLE1 degradation (Canis familiaris)
REACT:R-MMU-83660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-anchored TNF-α binds TNFR1 (Mus musculus)
GO:0102475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyeriodictyol 6C-glucoside dehydratase activity
REACT:R-HSA-451366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of p38MAPK by DSCAM (Homo sapiens)
RHEA:53542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O
REACT:R-HSA-6786500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)
REACT:R-CFA-5654643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
REACT:R-GGA-5653957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rag dimer formation (Gallus gallus)
RHEA:13529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-2-methylmalate dehydratase"
RHEA:13529	skos:altLabel	"mesaconate hydratase"
RHEA:13529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalate = H2O + mesaconate
RHEA:13529	skos:prefLabel	"(S)-2-methylmalate dehydratase"
REACT:R-RNO-190182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROD decarboxylates URO1 to COPRO1 (Rattus norvegicus)
REACT:R-HSA-9682465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)
REACT:R-SCE-72672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 60S subunit joins the translation initiation complex  (Saccharomyces cerevisiae)
GO:0103069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-hydroxyprogesterone 21-hydroxylase activity
REACT:R-MMU-5672969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of RAF (Mus musculus)
REACT:R-RNO-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Rattus norvegicus)
RHEA:55994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP
RHEA:14565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]
RHEA:63022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + NH4(+) => (9Z,12Z)-octadecadienamide + H2O
EC:1.17.1.4	skos:altLabel	"xanthine oxidoreductase"
EC:1.17.1.4	skos:altLabel	"xanthine/NAD(+) oxidoreductase"
EC:1.17.1.4	skos:prefLabel	"xanthine dehydrogenase"
EC:1.17.1.4	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"xanthine dehydrogenase"
EC:1.17.1.4	skos:altLabel	"xanthine-NAD oxidoreductase"
EC:1.17.1.4	skos:altLabel	"NAD-xanthine dehydrogenase"
REACT:R-CEL-469659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A1 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)
REACT:R-DRE-3229181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALM1:Ca2+ binds CNG channel (Danio rerio)
REACT:R-DME-390427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Drosophila melanogaster)
RHEA:38706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:64133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine
REACT:R-PFA-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Plasmodium falciparum)
REACT:R-GGA-5671702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP1G2 binds HGS and CHMP2A (Gallus gallus)
RHEA:56546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine
RHEA:32279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allantoate + 2 H(+) + 2 H2O = (S)-ureidoglycolate + CO2 + 2 NH4(+)
GO:0120021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxysterol transfer activity
GO:0120021	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	intermembrane oxysterol transfer activity
GO:0120021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxysterol carrier activity
REACT:R-RNO-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Rattus norvegicus)
RHEA:59294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + N-octadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O
REACT:R-SSC-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Sus scrofa)
REACT:R-DRE-396996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs binds G-protein Gq (Danio rerio)
RHEA:29796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + H2O(in) + Zn(2+)(out) => ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)
GO:0102793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	soyasapogenol B glucuronosyltransferase activity
REACT:R-HSA-6791219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)
RHEA:41652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin S + dTDP-2-deoxy-beta-L-fucose = 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)
RHEA:34705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-epi-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-BTA-5692764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 binds CCND3 (Bos taurus)
REACT:R-HSA-8964580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CCNA2 gene promoter (Homo sapiens)
REACT:R-SSC-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Sus scrofa)
REACT:R-CEL-8951966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates RUNX3 (Caenorhabditis elegans)
REACT:R-MMU-1067688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)
RHEA:33597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoyl-CoA
RHEA:18742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA => 10-deacetylbaccatin III + CoA
RHEA:64024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)
REACT:R-GGA-6788867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FN3K phosphorylates ketosamines (Gallus gallus)
RHEA:19251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate + glycine => glyoxylate + L-kynurenine
REACT:R-DRE-8854173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Danio rerio)
REACT:R-HSA-8849638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the SPINK5:KLK5 complex at low pH (Homo sapiens)
REACT:R-MMU-8854182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D17 binds OPTN:RAB8A (Mus musculus)
REACT:R-RNO-3788705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)
REACT:R-GGA-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Gallus gallus)
REACT:R-DRE-982765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Growth hormone forms dimers and oligomers (Danio rerio)
REACT:R-DRE-2512800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1:ligand is endocytosed (Danio rerio)
REACT:R-DME-109291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Drosophila melanogaster)
REACT:R-HSA-9036025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3 (Homo sapiens)
RHEA:12089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + UDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP
EC:2.4.1.162	skos:prefLabel	"aldose beta-D-fructosyltransferase"
EC:2.4.1.162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldose beta-D-fructosyltransferase"
REACT:R-HSA-110232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of thymine by MBD4 glycosylase (Homo sapiens)
REACT:R-RNO-8952419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURFs ubiquitinate RUNX3 (Rattus norvegicus)
REACT:R-HSA-5683888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMCD1 binds GATA6, sequestering it (Homo sapiens)
RHEA:55265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine
RHEA:49976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine
REACT:R-CFA-139909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BMF to mitochondria (Canis familiaris)
RHEA:14366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-carbamoyl-L-aspartate => CO2 + L-aspartate + NH4(+)
REACT:R-BTA-5666001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Profilin:G-actin binds MKL1 (Bos taurus)
REACT:R-SSC-8985153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OASL binds DDX58 (Sus scrofa)
REACT:R-HSA-182186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
REACT:R-SSC-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Sus scrofa)
RHEA:72017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A => acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine
REACT:R-DRE-5682588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 binds phosphorylated MDC1 at DNA DSBs (Danio rerio)
REACT:R-DRE-2022412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)
REACT:R-HSA-9624365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PLTP regulated by NR1H2 or NR1H3 (Homo sapiens)
RHEA:65467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-1-ol + butanoyl-CoA <=> 2-methylbutyl butanoate + CoA
REACT:R-MMU-3769383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBY1 binds beta-catenin (Mus musculus)
REACT:R-CFA-1855210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
RHEA:33369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate(in) + L-histidyl-[protein] => D-glucose(out) + N(pros)-phospho-L-histidyl-[protein]
RHEA:40258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenedioyl-CoA + H2O <=> (3R)-hydroxyhexadecanedioyl-CoA
REACT:R-CFA-8950731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRLF1:IL27 translocates to the extracellular region (Canis familiaris)
RHEA:55959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + AH2 + O2 <=> (12R)-hydroxy-(9Z)-octadecenoate + A + H2O
REACT:R-RNO-390598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Rattus norvegicus)
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-aminoisobutyrate-pyruvate transaminase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-beta-aminoisobutyrate:pyruvate aminotransferase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-aminoisobutyrate--pyruvate aminotransferase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-amino-2-methylpropanoate transaminase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-amino-2-methylpropanoate aminotransferase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-aminoisobutyrate-pyruvate aminotransferase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-3-aminoisobutyrate--pyruvate transaminase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-amino-2-methylpropionate transaminase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-aminoisobutyrate--pyruvate transaminase activity
GO:0047305	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-AIBAT activity
REACT:R-CFA-2484822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinetochore assembly (Canis familiaris)
RHEA:47766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1369) in 16S rRNA
RHEA:23185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate
REACT:R-SCE-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Saccharomyces cerevisiae)
REACT:R-HSA-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
REACT:R-RNO-193369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Rattus norvegicus)
REACT:R-DRE-4641229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLE oligomerizes (Danio rerio)
RHEA:24003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] <=> a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]
REACT:R-RNO-193073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Rattus norvegicus)
RHEA:51770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-prenylphlormethylbutanophenone + diphosphate => 2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate
RHEA:34387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP
RHEA:10636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannonate + NADP(+) = D-mannuronate + H(+) + NADPH
REACT:R-CEL-392054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Caenorhabditis elegans)
REACT:R-GGA-217209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Generation of a DNA double strand break (Gallus gallus)
RHEA:63200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10bS,4aR)-noroxomaritidine + H(+) + NADPH = (10bS,4aR)-oxomaritidine + NADP(+)
RHEA:18638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2 + NADP(+) => H(+) + NADPH
RHEA:67193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) => ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate
REACT:R-HSA-4084910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1 (Homo sapiens)
RHEA:13189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactolipase"
RHEA:13189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)
RHEA:13189	skos:prefLabel	"galactolipase"
RHEA:57588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(in) + taurodeoxycholate(in) => 2 Na(+)(out) + taurodeoxycholate(out)
REACT:R-DME-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Drosophila melanogaster)
REACT:R-PFA-189423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPO oxidises PPGEN9 to PRIN9 (Plasmodium falciparum)
REACT:R-MMU-391943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLT2 binds LTC4,LTD4,LTE4 (Mus musculus)
RHEA:48464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1b + H2O = ganglioside GA1 + N-acetylneuraminate
RHEA:36223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine
REACT:R-DRE-4341025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR3C1 (GR) with SUMO1 (Danio rerio)
REACT:R-HSA-379432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)
GO:0047917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPglucosidase activity
GO:0047917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDPglucose glucohydrolase activity
GO:0047917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-glucose glucohydrolase activity
GO:0047917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-glucosidase activity
GO:0047917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphoglucosidase activity
GO:0047917	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphate D-glucose glucohydrolase activity
REACT:R-XTR-6799203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Xenopus tropicalis)
REACT:R-MMU-389622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Mus musculus)
REACT:R-DRE-109671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Danio rerio)
RHEA:44830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-decanoyl-(R)-carnitine => (R)-carnitine + decanoyl-CoA
REACT:R-HSA-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Homo sapiens)
REACT:R-HSA-74448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium binds calmodulin (Homo sapiens)
REACT:R-RNO-183055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to EGFR (Rattus norvegicus)
RHEA:54411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
REACT:R-HSA-9610152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Homo sapiens)
REACT:R-BTA-1454916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The ABCC family mediates organic anion transport (Bos taurus)
REACT:R-DRE-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Danio rerio)
GO:0038022	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	odorant receptor activity, G-protein coupled
GO:0038022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	olfactory receptor activity, G-protein coupled
GO:0038022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled olfactory receptor activity
GO:0038022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled odorant receptor activity
GO:0038022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled olfactory receptor activity
REACT:R-PFA-70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Plasmodium falciparum)
EC:3.4.22.26	skos:prefLabel	"cancer procoagulant"
EC:3.4.22.26	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cancer procoagulant"
RHEA:19422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxypropyl-coenzyme M => (R)-1,2-epoxypropane + coenzyme M
GO:0044378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA bending involving non-sequence-specific DNA binding
GO:0044378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-sequence-specific DNA binding, bending
REACT:R-DRE-3245898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds correnoids in the circulation (Danio rerio)
REACT:R-MMU-416320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR1-containing  AMPA receptors (Mus musculus)
REACT:R-MMU-183089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds and ubiquitinates phosphorylated Sprouty (Mus musculus)
GO:0031545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-proline 4-dioxygenase activity
GO:0031545	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	prolyl 4-hydroxylase
GO:0031545	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	HIF-type prolyl 4-hydroxylase
RHEA:45541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-CEL-182994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of EGFR complex in clathrin-coated vesicles (Caenorhabditis elegans)
RHEA:58177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + 2 diphosphate + NADP(+)
RHEA:72521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate
REACT:R-SSC-1112565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Sus scrofa)
REACT:R-DRE-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Danio rerio)
RHEA:62392	skos:prefLabel	"levoglucosan dehydrogenase"
RHEA:62392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"levoglucosan dehydrogenase"
RHEA:62392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	levoglucosan + NAD(+) = 3-dehydrolevoglucosan + H(+) + NADH
RHEA:62392	skos:altLabel	"1,6-anhydro-beta-D-glucose dehydrogenase"
REACT:R-CEL-109636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recognition and Binding of Core Promoter Elements by TFIID (Caenorhabditis elegans)
GO:0140037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sumo-dependent protein binding
RHEA:36388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbamoyl adenylate + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + H(+)
REACT:R-GGA-8870354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports extracellular L-Pro to the cytosol (Gallus gallus)
RHEA:46286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:63879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 <=> (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate
REACT:R-RNO-2466106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BGN binds Collagen types I, VI, (IX) (Rattus norvegicus)
REACT:R-SSC-173723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C8 binds C5b:C6:C7 (Sus scrofa)
REACT:R-MMU-2309773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS2 (Mus musculus)
REACT:R-SSC-373734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin interacts with Podocin (Sus scrofa)
RHEA:39618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA <=> (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O
REACT:R-RNO-76056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Rattus norvegicus)
RHEA:41328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate
RHEA:52986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-carboxyhexanoyl-[ACP] + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin]
RHEA:11769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate => 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate
RHEA:66969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
REACT:R-HSA-2161779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LXA4 is oxidised to 15k-LXA4 by HPGD (Homo sapiens)
REACT:R-DRE-2002401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Danio rerio)
RHEA:57136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine
REACT:R-RNO-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Rattus norvegicus)
RHEA:68188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + phytol = CoA + dodecanoate phytyl ester
GO:0018664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate-para-hydroxylase activity
GO:0018664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoic acid 4-hydroxylase activity
GO:0018664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate 4-monooxygenase activity
GO:0018664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoic hydroxylase activity
GO:0018664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)
GO:0018664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoate hydroxylase activity
GO:0018664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate 4-hydroxylase activity
GO:0018664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate-p-hydroxylase activity
GO:0018664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoic 4-hydroxylase activity
REACT:R-BTA-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Bos taurus)
REACT:R-HSA-2046090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)
REACT:R-SSC-198845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYB5A:heme reduces Asc.- to AscH- (Sus scrofa)
REACT:R-XTR-71496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)
GO:0102977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrilotriacetate monooxygenase activity (FMN-dependent)
RHEA:11644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH
REACT:R-CFA-9653503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KRAS4B is phosphorylated on serine 181 (Canis familiaris)
REACT:R-MMU-2046092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Mus musculus)
REACT:R-XTR-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Xenopus tropicalis)
REACT:R-DME-202248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma1 (Drosophila melanogaster)
RHEA:67495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)
RHEA:41689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate
REACT:R-DME-428681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Drosophila melanogaster)
REACT:R-DRE-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Danio rerio)
REACT:R-DRE-1358797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated RNF41 binds P-USP8 (Danio rerio)
REACT:R-DRE-3247849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS dissociates from retromer (Danio rerio)
RHEA:20298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anilide + H2O => a carboxylate + aniline + H(+)
REACT:R-HSA-71249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Homo sapiens)
REACT:R-CFA-3928656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves EPHB2 (Canis familiaris)
REACT:R-RNO-202731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAM3 dimerises (Rattus norvegicus)
REACT:R-DME-6791221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Drosophila melanogaster)
REACT:R-CEL-198314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG stimulates protein kinase C-delta (Caenorhabditis elegans)
RHEA:56132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA = a thymidine dimer in DNA
RHEA:56132	skos:altLabel	"SP lyase"
RHEA:56132	skos:prefLabel	"spore photoproduct lyase"
RHEA:56132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spore photoproduct lyase"
GO:0050531	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity
GO:0050531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannosyl-3-phosphoglycerate phosphatase activity
RHEA:23979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + ATP <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate
RHEA:70927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate(in) + H(+)(in) = (R)-glycerate(out) + H(+)(out)
RHEA:18647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + sym-homospermidine => 2 putrescine
RHEA:56671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
REACT:R-RNO-75174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Rattus norvegicus)
REACT:R-BTA-5689085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 binds polyUb-PARK2 (Bos taurus)
REACT:R-GGA-350058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of CSL NCOR corepressor complex (Gallus gallus)
REACT:R-SPO-5607755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Schizosaccharomyces pombe)
REACT:R-CEL-75010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser 216 by Chk1 (Caenorhabditis elegans)
RHEA:58718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADH + rifampicin
REACT:R-CFA-2730899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of BCL10 and MALT1 (Canis familiaris)
REACT:R-RNO-3204318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Rattus norvegicus)
REACT:R-XTR-389919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds pBTLA (Xenopus tropicalis)
RHEA:55895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 <=> a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)
RHEA:38501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O
REACT:R-BTA-909732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT2 (Bos taurus)
REACT:R-PFA-77085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of  transcript with 5'-GMP from GT (Plasmodium falciparum)
REACT:R-XTR-1306972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)
RHEA:53552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:41192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate
RHEA:29088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + menaquinone-8 => menaquinol-8 + oxaloacetate
RHEA:57681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(out) + K(+)(out) + Na(+)(out) <=> 2 chloride(in) + K(+)(in) + Na(+)(in)
GO:0043855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic nucleotide activated ion channel activity
GO:0043855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic nucleotide gated ion channel activity
GO:0043855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic nucleotide-activated ion channel activity
GO:0043855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic nucleotide-gated ion channel activity
REACT:R-CEL-193824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Caenorhabditis elegans)
REACT:R-RNO-6800334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Rattus norvegicus)
REACT:R-BTA-9645414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Bos taurus)
REACT:R-MMU-70885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Mus musculus)
REACT:R-GGA-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Gallus gallus)
RHEA:49557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => H(+) + L-cysteinyl-[protein] + lactate
GO:0106156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-[protein] + CO2 + succinate
GO:0106156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-lysine 4-dioxygenase activity
REACT:R-DDI-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Dictyostelium discoideum)
REACT:R-RNO-201425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Rattus norvegicus)
REACT:R-HSA-1989760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of HMGCS2 (Homo sapiens)
REACT:R-SPO-109860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 phosphorylates MAPK3 (Schizosaccharomyces pombe)
REACT:R-XTR-5656105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Xenopus tropicalis)
REACT:R-DME-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Drosophila melanogaster)
RHEA:29997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + putrescine(in) => ATP + H2O + putrescine(out)
REACT:R-GGA-8866551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR binds components of the ERAD machinery for ubiquitination and degradation (Gallus gallus)
REACT:R-CEL-1236958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of particulate antigens with dendritic cell receptors (Caenorhabditis elegans)
REACT:R-MMU-6787757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K333-GADL1 decarboxylates acidic AAs (Mus musculus)
RHEA:22376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA pseudouridine(38-40) synthase"
RHEA:22376	skos:altLabel	"PSUI"
RHEA:22376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA
RHEA:22376	skos:altLabel	"tRNA pseudouridylate synthase I"
RHEA:22376	skos:prefLabel	"tRNA pseudouridine(38-40) synthase"
REACT:R-RNO-9654523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP bind PDE6D on KRAS4B (Rattus norvegicus)
REACT:R-MMU-5610726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The IFT-A complex recruits TULP3 (Mus musculus)
RHEA:70486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 <=> a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate
RHEA:14264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-CoA + D-glucono-1,5-lactone <=> 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA
REACT:R-RNO-1482887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Rattus norvegicus)
RHEA:56558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate
RHEA:41397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
REACT:R-RNO-428231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Rattus norvegicus)
REACT:R-DME-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Drosophila melanogaster)
REACT:R-BTA-416562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGAP binds Plexin-B1 (Bos taurus)
RHEA:17928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-arabinopyanose + NAD(+) <=> H(+) + L-arabinono-1,4-lactone + NADH
RHEA:63488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-phenanthroquinone + H(+) + NADPH = NADP(+) + phenanthrene-9,10-diol
REACT:R-XTR-70523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K314-GPT transaminates L-Ala to form PYR (Xenopus tropicalis)
REACT:R-HSA-202129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
RHEA:60267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:70542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)
RHEA:64904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + 2 H2O = GMP + 2 H(+) + 2 phosphate
REACT:R-DRE-5658435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS GAPs bind RAS:GTP (Danio rerio)
REACT:R-CEL-5244669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Caenorhabditis elegans)
RHEA:29411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate(in) + H(+)(in) = glycolate(out) + H(+)(out)
REACT:R-SSC-74736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Sus scrofa)
RHEA:29986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(in) + H(+)(in) <=> cytidine(out) + H(+)(out)
RHEA:16574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-(phosphooxy)-L-threonine => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate
RHEA:65354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate
REACT:R-CFA-8875540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 recruits CRK,CRKL to MET (Canis familiaris)
RHEA:70325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-carboxy-L-lyxonolactone => 2,3-dioxo-L-gulonate
RHEA:44662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine
RHEA:30930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose
REACT:R-HSA-8873830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 transports PC from ER membrane to mitochondrial outer membrane (Homo sapiens)
REACT:R-MMU-1250348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SHC1 by ERBB4 homodimers (Mus musculus)
REACT:R-SSC-68954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm2-7 is phosphorylated by DDK (Sus scrofa)
REACT:R-GGA-2328037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds integrins (Gallus gallus)
GO:0033901	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endoribonuclease V activity
GO:0033901	skos:prefLabel	"ribonuclease V"
GO:0033901	skos:altLabel	"endoribonuclease V"
GO:0033901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ribonuclease V activity
GO:0033901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribonuclease V"
RHEA:53588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + resolvin D2 = 16-oxoresolvin D2 + H(+) + NADH
REACT:R-RNO-6805122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB binds TP53 (Rattus norvegicus)
REACT:R-SSC-1855223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Sus scrofa)
GO:0070967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420 binding
REACT:R-XTR-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Xenopus tropicalis)
RHEA:34300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyneamine + 2-oxoglutarate => 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate
RHEA:68679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) <=> adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)
RHEA:21544	skos:prefLabel	"farnesyl-diphosphate kinase"
RHEA:21544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP
RHEA:21544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"farnesyl-diphosphate kinase"
REACT:R-HSA-5610735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB binds ITCH (Homo sapiens)
RHEA:28378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fructoselysine 6-kinase"
RHEA:28378	skos:prefLabel	"fructoselysine 6-kinase"
RHEA:28378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(6)-(D-fructosyl)-L-lysine = ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine
RHEA:18929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O
RHEA:18929	skos:altLabel	"thiophene-2-carboxyl-CoA dehydrogenase"
RHEA:18929	skos:altLabel	"thiophene-2-carboxyl-CoA hydroxylase"
RHEA:18929	skos:altLabel	"thiophene-2-carboxyl-CoA monooxygenase"
RHEA:18929	skos:prefLabel	"thiophene-2-carbonyl-CoA monooxygenase"
RHEA:18929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiophene-2-carbonyl-CoA monooxygenase"
REACT:R-GGA-374680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 trans-homophilic interaction (Gallus gallus)
REACT:R-RNO-399952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIMK-1 by PAK (Rattus norvegicus)
REACT:R-DRE-2454264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11cROL binds to RLBP1 to form RLBP1:11cROL (Danio rerio)
REACT:R-MMU-9018766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU binds effectors at the plasma membrane (Mus musculus)
RHEA:64881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP + H2O => CMP + H(+) + phosphate
REACT:R-HSA-5654584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS bind to PPTN11 (Homo sapiens)
REACT:R-HSA-156923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of eEF1A:GTP (Homo sapiens)
REACT:R-HSA-2466370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRF1:PPARGC1B binds the CYCS promoter (Homo sapiens)
GO:0045300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity
GO:0045300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-[acyl-carrier protein] desaturase activity
GO:0045300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-acyl-carrier-protein desaturase activity
GO:0045300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	stearyl acyl carrier protein desaturase activity
GO:0045300	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	stearyl-ACP desaturase activity
GO:0045300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl-[acyl-carrier-protein] desaturase activity
GO:0097645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amylin binding
RHEA:68431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutein + O2 <=> (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone
REACT:R-BTA-4084989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Bos taurus)
RHEA:31944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
GO:0030158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-xylose:core protein xylosyltransferase activity
GO:0030158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoxylose-core protein beta-xylosyltransferase activity
GO:0030158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-xylose-core protein beta-D-xylosyltransferase activity
GO:0030158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity
GO:0030158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoxylose-protein xylosyltransferase activity
GO:0030158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-xylose:protein beta-D-xylosyltransferase activity
GO:0030158	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-D-xylose:core protein beta-D-xylosyltransferase activity
GO:0030158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein xylosyltransferase activity
GO:0030158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide O-xylosyltransferase activity
RHEA:71424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)
GO:0018666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)
GO:0018666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,4-dichlorophenol monooxygenase activity
GO:0018666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorophenol 6-monooxygenase activity
GO:0018666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichlorophenol hydroxylase activity
GO:0052735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transfer ribonucleate cytosine 3-methyltransferase activity
GO:0052735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA cytosine 3-methyltransferase activity
GO:0052735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:tRNA cytosine-3-methyltransferase activity
GO:0052735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (cytosine-3-)-methyltransferase activity
GO:0052735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA cytosine-3-methyltransferase activity
GO:0052735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine:tRNA (cytosine-3-)-methyltransferase activity
GO:0052735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (cytosine 3)-methyltransferase activity
RHEA:62781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
REACT:R-MMU-450690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Mus musculus)
RHEA:33144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol(in) => galactitol(out)
REACT:R-CFA-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Canis familiaris)
REACT:R-XTR-112435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin BC complex (Xenopus tropicalis)
REACT:R-MMU-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Mus musculus)
REACT:R-HSA-2465883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds collagens I, IV and VI (Homo sapiens)
REACT:R-GGA-3697860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Gallus gallus)
RHEA:14715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-fructose + AH2 => A + keto-L-sorbose
REACT:R-HSA-9635666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esxG:esxH translocates from MTb cytosol to host phagosomal lumen (Homo sapiens)
REACT:R-BTA-429529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin binding to GP1b:IX:V (Bos taurus)
REACT:R-XTR-193072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)
REACT:R-DRE-376141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ABL with ROBO1:SLIT2 (Danio rerio)
EC:2.7.1.159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"inositol-1,3,4-trisphosphate 5/6-kinase"
EC:2.7.1.159	skos:altLabel	"Ins(1,3,4)P3 5/6-kinase"
EC:2.7.1.159	skos:altLabel	"IP56K"
EC:2.7.1.159	skos:altLabel	"inositol trisphosphate 5/6-kinase"
EC:2.7.1.159	skos:prefLabel	"inositol-1,3,4-trisphosphate 5/6-kinase"
REACT:R-DME-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Drosophila melanogaster)
REACT:R-XTR-186780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3-kinase binds to the active receptor (Xenopus tropicalis)
REACT:R-SSC-1606564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide (Sus scrofa)
RHEA:67938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + H2O2 => a 2-hydroxy carboxylate + O2
REACT:R-RNO-190263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3b binds to FGF (Rattus norvegicus)
RHEA:10106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A1 + succinate => 2-oxoglutarate + gibberellin A20 + O2
REACT:R-HSA-351876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of occludin (Homo sapiens)
REACT:R-SSC-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Sus scrofa)
REACT:R-XTR-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Xenopus tropicalis)
RHEA:44181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:24097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoorientin + S-adenosyl-L-methionine => H(+) + isoscoparin + S-adenosyl-L-homocysteine
REACT:R-CFA-177930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 phosphorylation by EGFR kinase (Canis familiaris)
REACT:R-HSA-8852266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Homo sapiens)
RHEA:40036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + N-acetyl-L-aspartate => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate
REACT:R-DRE-432129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGR binds and phosphorylates LRP8 (Danio rerio)
GO:0034387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyrate:pyruvate transaminase activity
GO:0034387	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-aminobutyric acid pyruvate transaminase activity
REACT:R-DRE-983140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
RHEA:20277	skos:altLabel	"arylhydroxamate N,O-acetyltransferase"
RHEA:20277	skos:altLabel	"arylamine N-acetyltransferase"
RHEA:20277	skos:prefLabel	"N-hydroxyarylamine O-acetyltransferase"
RHEA:20277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-hydroxyarylamine O-acetyltransferase"
RHEA:20277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an N-hydroxyarylamine = an N-acetoxyarylamine + CoA
GO:0102873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity
REACT:R-DRE-3364026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SET1 complex trimethylates H3K4 at the MYC gene (Danio rerio)
RHEA:44443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,3-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol
RHEA:17687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + uracil => H(+) + uracil 5-carboxylate
REACT:R-SSC-2681667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Sus scrofa)
REACT:R-RNO-9748996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GST dimers cleave AZA to 6MP (Rattus norvegicus)
RHEA:58376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decan-1-ol + NADP(+) = decanal + H(+) + NADPH
REACT:R-DRE-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Danio rerio)
REACT:R-RNO-1462014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha-defensins form biologically active dimers (Rattus norvegicus)
RHEA:46152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + a plastoquinone = 15,9'-di-cis-phytofluene + a plastoquinol
REACT:R-DME-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Drosophila melanogaster)
REACT:R-RNO-166817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by C3 convertases (Rattus norvegicus)
RHEA:29574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-idonate(in) <=> H(+)(out) + L-idonate(out)
REACT:R-DRE-548818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Danio rerio)
RHEA:11331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + neryl diphosphate
REACT:R-CFA-166387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The FA anion diffuses away laterally from UCP (Canis familiaris)
REACT:R-DDI-8942803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Dictyostelium discoideum)
REACT:R-XTR-1602417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Xenopus tropicalis)
RHEA:50431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methanethiol + S-adenosyl-L-methionine <=> dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9634390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB2 homodimer phosphorylates SHC1 (Homo sapiens)
REACT:R-BTA-9009558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds SDC1 (Bos taurus)
RHEA:10925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide
REACT:R-BTA-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Bos taurus)
REACT:R-DDI-8874718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTPA binds alpha-TOH (Dictyostelium discoideum)
REACT:R-BTA-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Bos taurus)
RHEA:53795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylthiol + O2 <=> benzothialdehyde + H2O2
GO:0033678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
GO:0033678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-3' DNA/RNA helicase activity
GO:0033678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 5' to 3' DNA/RNA helicase activity
GO:0033678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 5'-3' DNA/RNA helicase activity
GO:0033678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' to 3' DNA/RNA helicase activity
REACT:R-BTA-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Bos taurus)
REACT:R-MMU-1855202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Mus musculus)
RHEA:20518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-galactosamine
RHEA:27703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galacturonate => keto-D-tagaturonate
RHEA:13574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP
REACT:R-DME-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Drosophila melanogaster)
RHEA:38731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol
REACT:R-SSC-9018798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOV binds GTP (Sus scrofa)
REACT:R-SSC-6804100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 binds LPS (Sus scrofa)
REACT:R-DDI-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Dictyostelium discoideum)
GO:0047118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity
GO:0047118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
GO:0047118	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity
REACT:R-SCE-204662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)
REACT:R-SSC-158849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phenol can form a sulfate conjugate (Sus scrofa)
REACT:R-HSA-8852552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1R autophosphorylates (Homo sapiens)
RHEA:59750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein] => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein]
REACT:R-SCE-2046093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosapentaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)
RHEA:11834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + naphthalene-1,2-diol => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)
REACT:R-DDI-1793186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Dictyostelium discoideum)
RHEA:59448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecan-1-ol + NADP(+) = dodecanal + H(+) + NADPH
REACT:R-BTA-9605682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Bos taurus)
REACT:R-RNO-110137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Rattus norvegicus)
RHEA:70426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + H2O <=> a carboxylate + CoA + H(+)
REACT:R-BTA-9605609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Bos taurus)
REACT:R-CFA-191636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cx43 by c-src (Canis familiaris)
REACT:R-DRE-9027273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Danio rerio)
EC:1.1.1.105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-retinol dehydrogenase (NAD(+))"
EC:1.1.1.105	skos:prefLabel	"all-trans-retinol dehydrogenase (NAD(+))"
GO:0043139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 5' to 3' DNA helicase activity
GO:0043139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
GO:0043139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' to 3' DNA helicase activity
GO:0043139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-3' DNA helicase activity
GO:0043139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 5'-3' DNA helicase activity
GO:0043139	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	DNA helicase IV activity
REACT:R-SSC-8987266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Sus scrofa)
RHEA:22160	skos:prefLabel	"flavonol-3-O-triglucoside O-coumaroyltransferase"
RHEA:22160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavonol-3-O-triglucoside O-coumaroyltransferase"
RHEA:22160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside = a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA
RHEA:71257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(in) + phosphate(in) => 3 Na(+)(out) + phosphate(out)
REACT:R-DME-5672961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates inactive RAFs (Drosophila melanogaster)
RHEA:48822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2
RHEA:55764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
GO:0034945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity
EC:1.1.1.121	skos:prefLabel	"aldose 1-dehydrogenase (NAD(+))"
EC:1.1.1.121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aldose 1-dehydrogenase (NAD(+))"
RHEA:42600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + prostaglandin G2 = A + H2O + prostaglandin H2
REACT:R-RNO-211206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of DFF to the nucleus (Rattus norvegicus)
RHEA:49685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NAD(+)
RHEA:64532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-HSA-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Homo sapiens)
RHEA:64165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-L-serine => formaldehyde + L-alanine
RHEA:29793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + glutathione(in) + H(+) + phosphate => ATP + glutathione(out) + H2O
RHEA:57295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O <=> a guanosine in RNA + glycolate + H(+)
RHEA:23762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n)
REACT:R-HSA-5334179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT3A:DNMT3L binds chromatin (Homo sapiens)
GO:0061677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-keto-3-deoxygluconate aldolase activity
GO:0061677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate aldolase activity
GO:0061677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDG aldolase activity
GO:0140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate dehydrogenase activity
GO:0140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-2-hydroxyglutarate dehydrogenase"
GO:0140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol
GO:0140696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-hydroxyglutarate dehydrogenase activity
GO:0140696	skos:prefLabel	"(S)-2-hydroxyglutarate dehydrogenase"
GO:0140696	skos:altLabel	"L-2-hydroxyglutarate dehydrogenase"
RHEA:65449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + ethanol => CoA + ethyl butanoate
REACT:R-XTR-9603804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX19 binds class I peroxisomal membrane proteins (Xenopus tropicalis)
REACT:R-CFA-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Canis familiaris)
RHEA:70034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-77256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Danio rerio)
RHEA:13567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol
RHEA:68415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamate 5-semialdehyde + NADP(+) <=> 2 H(+) + L-glutamate + NADPH
REACT:R-RNO-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
REACT:R-DRE-74180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMG CoA => acetoacetic acid + acetyl CoA (Danio rerio)
REACT:R-MMU-6797554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABP1 binds SHANK proteins (Mus musculus)
REACT:R-GGA-451447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 (Gallus gallus)
RHEA:71519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(out) = uridine(in)
GO:0018680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deethylatrazine monooxygenase activity
REACT:R-HSA-174444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C-strand Okazaki fragments (Homo sapiens)
REACT:R-MMU-5668735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1:GTP binds NOX3 complex (Mus musculus)
REACT:R-HSA-9700662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Homo sapiens)
REACT:R-SCE-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Saccharomyces cerevisiae)
RHEA:15558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Ni(2+)(out) => ADP + H(+) + Ni(2+)(in) + phosphate
REACT:R-CFA-372449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Canis familiaris)
REACT:R-CEL-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)
REACT:R-MMU-8848314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36:IL1RL2 binds IL1RAP-1 (Mus musculus)
REACT:R-SSC-5682893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12:ATG7:CysO572-ATG7 binds ATG10 (Sus scrofa)
GO:0102500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-maltose 4-alpha-glucanotransferase activity
REACT:R-BTA-5665748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds RHOC:GTP (Bos taurus)
RHEA:19382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-oxalosuccinate + H(+) => 2-oxoglutarate + CO2
RHEA:21492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"o-pyrocatechuate decarboxylase"
RHEA:21492	skos:altLabel	"2,3-dihydroxybenzoic acid decarboxylase"
RHEA:21492	skos:altLabel	"2,3-dihydroxybenzoate carboxy-lyase"
RHEA:21492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoate + H(+) = catechol + CO2
RHEA:21492	skos:altLabel	"2,3-DHBA decarboxylase"
RHEA:21492	skos:prefLabel	"o-pyrocatechuate decarboxylase"
RHEA:27348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)
REACT:R-MMU-4551451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Mus musculus)
RHEA:71684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(out) + L-aspartyl-glycine(out) => 2 H(+)(in) + L-aspartyl-glycine(in)
RHEA:26424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate => 3'-phosphoadenylyl sulfate + thyroxine
RHEA:64926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP + 2 H(+) + 2 phosphate => dATP + 2 H2O
RHEA:66886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate
REACT:R-DRE-5628905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Danio rerio)
RHEA:62700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + naphtopyrone YWA1 = acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol
REACT:R-CFA-5654586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS binds GRB2:SOS1 (Canis familiaris)
RHEA:26163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> thalianol
REACT:R-SPO-9020252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Schizosaccharomyces pombe)
REACT:R-SSC-975139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Sus scrofa)
GO:0071949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized flavin adenine dinucleotide binding
GO:0071949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized flavine-adenine dinucleotide binding
GO:0071949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD binding
REACT:R-CFA-2076419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Canis familiaris)
RHEA:48047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 (d18:1(4E)/18:0) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E)/18:0)
RHEA:50225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-4420121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylate PLCG1 (Homo sapiens)
REACT:R-SCE-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Saccharomyces cerevisiae)
GO:0015467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein enhanced inward rectifier potassium channel activity
GO:0015467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Homo sapiens)
GO:0015467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein enhanced inward rectifier potassium channel activity
GO:0015467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein activated inward rectifier potassium channel activity
GO:0015467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein activated inward rectifier potassium channel activity
GO:0015467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein-enhanced inward rectifier potassium channel activity
GO:0015467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein-activated inward rectifier potassium channel activity
RHEA:64563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-2-ol + NAD(+) <=> butan-2-one + H(+) + NADH
REACT:R-CEL-742345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Caenorhabditis elegans)
REACT:R-BTA-9011985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Bos taurus)
REACT:R-MMU-1295609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates SPRY2 on Y55 and Y227 (Mus musculus)
REACT:R-SSC-193719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Sus scrofa)
REACT:R-RNO-5357928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLIP3 and CYLD bind TNF signaling complex (Rattus norvegicus)
RHEA:16386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + 2 H(+) + NADPH + O2 => CO2 + H2O + hydroquinone + NADP(+)
REACT:R-CFA-8874079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 binds activated MET (Canis familiaris)
REACT:R-RNO-1234171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Rattus norvegicus)
RHEA:56486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-879674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD97 binds CD55 (Homo sapiens)
EC:3.4.13.7	skos:altLabel	"alpha-glutamyl-glutamate dipeptidase"
EC:3.4.13.7	skos:prefLabel	"Glu-Glu dipeptidase"
EC:3.4.13.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Glu-Glu dipeptidase"
GO:0015149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexose transmembrane transporter activity
REACT:R-BTA-381412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP2 binds IGF forming IGF:IGFBP2 (Bos taurus)
RHEA:17097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylpyruvate tautomerase"
RHEA:17097	skos:altLabel	"phenylpyruvic keto--enol isomerase"
RHEA:17097	skos:altLabel	"phenylpyruvate keto--enol tautomerase"
RHEA:17097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate = enol-phenylpyruvate
RHEA:17097	skos:prefLabel	"phenylpyruvate tautomerase"
GO:0018859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate:CoA ligase (AMP-forming)
GO:0018859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoyl coenzyme A synthetase activity
GO:0018859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate-coenzyme A ligase (AMP-forming)
GO:0018859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoyl-CoA ligase activity
GO:0018859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-hydroxybenzoate-CoA synthetase activity
GO:0018859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate-CoA ligase activity
REACT:R-SCE-71299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
REACT:R-RNO-8949688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Rattus norvegicus)
REACT:R-GGA-8849085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RHOA:GTP (Gallus gallus)
REACT:R-MMU-2130500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insertion of MHC II:Ii complex in to the plasma membrane (Mus musculus)
REACT:R-DRE-975311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Danio rerio)
REACT:R-MMU-914012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Mus musculus)
RHEA:36745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosenoyl-CoA
REACT:R-XTR-1855159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Xenopus tropicalis)
RHEA:60860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Dictyostelium discoideum)
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascorbate oxidase activity
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ascorbate:oxygen oxidoreductase activity
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascorbase activity
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate oxidase activity
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-ascorbate oxidase"
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AAO
GO:0008447	skos:altLabel	"ascorbase"
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ascorbate:O2 oxidoreductase activity
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascorbic oxidase activity
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascorbic acid oxidase activity
GO:0008447	skos:prefLabel	"L-ascorbate oxidase"
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 L-ascorbate + O2 = 2 H2O + 4 monodehydro-L-ascorbate radical
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-ascorbic acid oxidase activity
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ascorbate dehydrogenase activity
GO:0008447	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AA oxidase activity
REACT:R-SSC-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Sus scrofa)
RHEA:14017	skos:prefLabel	"ribosylnicotinamide kinase"
RHEA:14017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-nicotinamide D-riboside = ADP + beta-nicotinamide D-ribonucleotide + H(+)
RHEA:14017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribosylnicotinamide kinase"
REACT:R-DME-186798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAP binds to PDGF-beta receptors only (Drosophila melanogaster)
RHEA:28954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-arabinose(in) <=> H(+)(out) + L-arabinose(out)
RHEA:17227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin]
GO:0103039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein methylthiotransferase activity
GO:0103039	skos:altLabel	"[ribosomal protein S12] (aspartate-C(3))-methylthiotransferase"
GO:0103039	skos:prefLabel	"[ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase"
GO:0103039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine
GO:0103039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase"
GO:0004056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	argininosuccinic acid lyase activity
GO:0004056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate lyase activity
GO:0004056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
GO:0004056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine-succinate lyase activity
GO:0004056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	omega-N-(L-arginino)succinate arginine-lyase activity
GO:0004056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(L-argininosuccinate) arginine-lyase activity
GO:0004056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)
GO:0004056	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginosuccinase activity
RHEA:10334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA
REACT:R-HSA-939763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Homo sapiens)
REACT:R-SPO-70475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Schizosaccharomyces pombe)
REACT:R-CEL-9762093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTRC binds p-S335, 338 NFE2L2 (Caenorhabditis elegans)
GO:0008096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	juvenile hormone epoxide hydrolase activity
RHEA:29928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantothenate(in) + Na(+)(in) => (R)-pantothenate(out) + Na(+)(out)
REACT:R-DME-5696230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO1 dimer reduces methylarsonate to methylarsonite (Drosophila melanogaster)
REACT:R-CEL-9695949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 phosphorylates SPG to S1P (Caenorhabditis elegans)
REACT:R-MMU-2426471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Mus musculus)
REACT:R-DRE-3899291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of EP300 with SUMO1 (Danio rerio)
GO:0062205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miltiradiene synthase activity
GO:0062205	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	multiradiene synthase activity
REACT:R-HSA-445367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CaMKII binds activated NMDA receptor (Homo sapiens)
REACT:R-HSA-9683718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein M localizes to the Golgi membrane (Homo sapiens)
REACT:R-CFA-1474184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHNTP is dephosphorylated by PTPS to PTHP (Canis familiaris)
REACT:R-DRE-446216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Danio rerio)
REACT:R-SSC-74249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Sus scrofa)
GO:0016295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0016295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetradecanoyl-[acyl-carrier-protein] hydrolase activity
GO:0016295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-ACP hydrolase activity
GO:0016295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myristoyl-[acyl-carrier protein] hydrolase activity
GO:0016295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetradecanoyl-ACP hydrolase activity
REACT:R-HSA-190141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD binds to Pb2+ (Homo sapiens)
GO:0004869	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thiol protease inhibitor
GO:0004869	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cysteine protease inhibitor activity
GO:0004869	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cystatin
GO:0004869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type endopeptidase inhibitor activity
REACT:R-HSA-9603598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAX activation is stimulated by NTRK3(495-641) and NELFB (Homo sapiens)
RHEA:56429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)
GO:0030293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor protein tyrosine kinase inhibitor activity
REACT:R-CEL-8937016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)
REACT:R-CFA-5632668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMO translocates to the cilium (Canis familiaris)
REACT:R-MMU-209828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tryptophan is hydroxylated (Mus musculus)
RHEA:38139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
GO:0018557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity
RHEA:22403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androstan-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxyandrostanone + H(+) + NADH
RHEA:56338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-5250210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Canis familiaris)
RHEA:39786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0004451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ICL activity
GO:0004451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocitrate glyoxylate-lyase activity
GO:0004451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocitratase activity
GO:0004451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threo-DS-isocitrate glyoxylate-lyase activity
GO:0004451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocitrase activity
GO:0004451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocitrate glyoxylate-lyase (succinate-forming)
GO:0004451	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isocitritase activity
GO:0004451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate lyase activity
RHEA:32212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-5-oxohex-2-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate
REACT:R-MMU-6797974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRTMs bind NRXNs (Mus musculus)
RHEA:46531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:57825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP + H2O => 2-deoxy-D-ribose 5-phosphate + adenine
REACT:R-HSA-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Homo sapiens)
EC:3.4.24.84	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Ste24 endopeptidase"
EC:3.4.24.84	skos:altLabel	"prenyl protein-specific endoprotease 1"
EC:3.4.24.84	skos:prefLabel	"Ste24 endopeptidase"
EC:3.4.24.84	skos:altLabel	"CAAX prenyl protease 1"
GO:0033831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kojibiose phosphorylase activity
GO:0033831	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity
GO:0052809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acharan sulfate lyase activity
REACT:R-HSA-8953946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
RHEA:38544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]
RHEA:38588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vancomycin aglycone => devancoaminyl-vancomycin + UDP
REACT:R-DRE-913996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA/PKG phosphorylate Rap1GAP2 (Danio rerio)
REACT:R-HSA-8986940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET gene transcription is stimulated by MECP2 (Homo sapiens)
REACT:R-HSA-5602295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F22 20-hydroxylates TrXA3 (Homo sapiens)
REACT:R-DRE-2424485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-PLCG1 (Danio rerio)
GO:0051021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-dissociation inhibitor binding
GO:0051021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDI binding
RHEA:52993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine => [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine
REACT:R-HSA-5662653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT4 binds zinc (Homo sapiens)
RHEA:61056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]
RHEA:40437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O
RHEA:26490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary nitroalkane + H2O + O2 = a ketone + H(+) + H2O2 + nitrite
RHEA:69978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-4088264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Xenopus tropicalis)
RHEA:54664	skos:prefLabel	"pre-alpha-onocerin synthase"
RHEA:54664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pre-alpha-onocerin synthase"
RHEA:54664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene = pre-alpha-onocerin
RHEA:13524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate
REACT:R-BTA-416929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGFR binds PGF2a (Bos taurus)
RHEA:15773	skos:prefLabel	"glycerone kinase"
RHEA:15773	skos:altLabel	"dihydroxyacetone kinase"
RHEA:15773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate + H(+)
RHEA:15773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycerone kinase"
REACT:R-DRE-428534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Profilin by Ena/VASP proteins (Danio rerio)
RHEA:30405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Fe(3+)(out) + L-ascorbate(in)
REACT:R-PFA-5656148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLI incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)
REACT:R-XTR-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Xenopus tropicalis)
REACT:R-GGA-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Gallus gallus)
RHEA:53468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:24321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:33128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + salicin-6-phosphate => beta-D-glucose 6-phosphate + salicyl alcohol
REACT:R-DRE-2453863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRA6 transports atROL from extracellular region to cytosol (Danio rerio)
RHEA:35038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) <=> 4-aminobutanoate(out)
RHEA:23429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
REACT:R-CEL-163743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Caenorhabditis elegans)
RHEA:65888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-hydroxy-L-kynurenine = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate
REACT:R-PFA-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Plasmodium falciparum)
RHEA:17373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-antheraxanthin = all-trans-capsanthin
REACT:R-XTR-199202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphopantetheine conjugation of the ACP domain of FAS (Xenopus tropicalis)
RHEA:52260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1),7(1)-dihydroxybacteriochlorophyllide c = a bacteriochlorophyllide e + H2O
REACT:R-SSC-70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Sus scrofa)
REACT:R-XTR-445448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HHIP binds Hedgehog (Xenopus tropicalis)
RHEA:32050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-pentaphosphate + AMP + 2 H(+)
REACT:R-SSC-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Sus scrofa)
RHEA:22531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP
RHEA:66780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O = N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate
EC:1.14.20.5	skos:altLabel	"FNS I"
EC:1.14.20.5	skos:prefLabel	"flavone synthase I"
EC:1.14.20.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavone synthase I"
REACT:R-BTA-3928595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-WASP binds ARP2/3 and G-actin (Bos taurus)
EC:4.1.99.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geosmin synthase"
EC:4.1.99.16	skos:prefLabel	"geosmin synthase"
RHEA:22593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate => (10Z,15Z)-12-oxophytodienoate
REACT:R-MMU-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Mus musculus)
REACT:R-SSC-8868072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
RHEA:10459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + D-maltose <=> 1-O-acetylmaltose + CoA
GO:0047278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin glucuronoside glucuronosyltransferase activity
GO:0047278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity
GO:0047278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin monoglucuronide transglucuronidase activity
GO:0047278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bilirubin-glucuronoside glucuronosyltransferase activity
REACT:R-SSC-427656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-CFA-9650473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPING1 is secreted (Canis familiaris)
RHEA:44243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol
REACT:R-BTA-9695890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPNS2 transports S1P from cytosol to extracellular region (Bos taurus)
RHEA:46514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-SSC-6789031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)
GO:0004578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity
GO:0004578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity
GO:0004578	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity
GO:0004578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chitobiosyldiphosphodolichol beta-mannosyltransferase activity
RHEA:41031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA
REACT:R-XTR-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Xenopus tropicalis)
RHEA:40032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate + H2O => diphosphate + ent-manool
RHEA:59971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-threonyl-[protein]
RHEA:24316	skos:prefLabel	"copalyl diphosphate synthase"
RHEA:24316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"copalyl diphosphate synthase"
RHEA:24316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = (+)-copalyl diphosphate
REACT:R-GGA-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Gallus gallus)
REACT:R-HSA-2025890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds NFATC1,2,3 (Homo sapiens)
RHEA:72313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione(out) + taurocholate(in) => glutathione(in) + taurocholate(out)
REACT:R-GGA-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Gallus gallus)
RHEA:32632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin D + H(+) + NADPH + O2 => erythromycin C + H2O + NADP(+)
RHEA:67537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine
RHEA:36124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A20 + S-adenosyl-L-methionine => gibberellin A20 methyl ester + S-adenosyl-L-homocysteine
REACT:R-BTA-199206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Bos taurus)
REACT:R-BTA-174916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of N-glucuronides (Bos taurus)
RHEA:45498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit] => phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit]
REACT:R-MMU-9700175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates SHC1 (Mus musculus)
RHEA:52778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
GO:0033450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUC codon-amino acid adaptor activity
GO:0033450	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	valine tRNA
GO:0033450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTC codon-amino acid adaptor activity
REACT:R-DME-214859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
REACT:R-RNO-8866283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)
REACT:R-BTA-3772434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Bos taurus)
REACT:R-GGA-9614273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADGRG heterodimer translocates to plasma membrane (Gallus gallus)
RHEA:42844	skos:altLabel	"pikromycin PKS"
RHEA:42844	skos:prefLabel	"narbonolide synthase"
RHEA:42844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"narbonolide synthase"
RHEA:42844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH = 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide
RHEA:42477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,2',3-trihydroxydiphenyl ether + H(+) + O2 => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate
GO:0000386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lariat formation, 5'-splice site cleavage
GO:0000386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	second spliceosomal transesterification activity
GO:0000386	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3'-splice site cleavage, exon ligation
GO:0034009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoprene synthase activity
GO:0034009	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity
GO:0034009	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ISPC
GO:0034009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoprene synthase"
GO:0034009	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ISPS
GO:0034009	skos:altLabel	"ISPC"
GO:0034009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate = diphosphate + isoprene
GO:0034009	skos:altLabel	"ISPS"
GO:0034009	skos:prefLabel	"isoprene synthase"
REACT:R-SSC-2294580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 hyperphosphorylates Condensin II complex (Sus scrofa)
RHEA:29430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) <=> (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)
RHEA:31279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate
RHEA:33716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyeicosasphinganine 1-phosphate => 2-hydroxyoctadecanal + phosphoethanolamine
REACT:R-CFA-5579023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA2(869-1464) binds KAT6A(1-1118) (Canis familiaris)
REACT:R-GGA-1602488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by plasmin and trypsin (Gallus gallus)
RHEA:12005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indoxyl + UDP-alpha-D-glucose => H(+) + indican + UDP
RHEA:70736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + glycine betaine(out) + 2 Na(+)(out) => chloride(in) + glycine betaine(in) + 2 Na(+)(in)
REACT:R-CEL-162857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Caenorhabditis elegans)
REACT:R-DME-6792572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Drosophila melanogaster)
RHEA:13254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)
RHEA:39952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
GO:0042805	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-actinin binding
GO:0042805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actinin binding
GO:0042805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	capZ binding
REACT:R-BTA-69685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK2 phosphorylates TP53 (Bos taurus)
RHEA:48832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
RHEA:47594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GP1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E))
REACT:R-SPO-1482920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Schizosaccharomyces pombe)
RHEA:12439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoyl-CoA + putrescine <=> CoA + H(+) + N-caffeoylputrescine
REACT:R-DRE-5624954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INPP5E translocates to the primary cilium (Danio rerio)
REACT:R-HSA-8864595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2B homodimer binds YEATS4 (Homo sapiens)
RHEA:15990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mevalonate + CoA + 2 NADP(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH
REACT:R-RNO-976991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prolactin receptor ligands bind the prolactin receptor (Rattus norvegicus)
REACT:R-HSA-9750942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP14 deubiquitinates NLRC5 (Homo sapiens)
RHEA:16515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CO2 + H2O => (S)-lactate + O2
RHEA:31664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + UDP-N-acetylbacillosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose
RHEA:33840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) => 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate
REACT:R-BTA-201521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK autophosphorylation downstream of PTN and MDK (Bos taurus)
REACT:R-HSA-193696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Homo sapiens)
REACT:R-RNO-2029455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIA with IgG-coated Ag (Rattus norvegicus)
RHEA:19148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-sulfate + H2O <=> D-glucose + H(+) + sulfate
RHEA:65019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorothalonil + H2O <=> 4-hydroxychlorothalonil + chloride + 2 H(+)
REACT:R-HSA-1362417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)
REACT:R-CEL-392834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of EPACs by cAMP (Caenorhabditis elegans)
EC:1.3.-.-	skos:prefLabel	"Acting on the CH-CH group of donors"
EC:1.3.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on the CH-CH group of donors"
REACT:R-MMU-5654985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Mus musculus)
REACT:R-DRE-2076508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HS2ST1 sulfates IdoA at C2 in heparan sulfate (Danio rerio)
REACT:R-BTA-3928620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 autophosphorylates (Bos taurus)
REACT:R-DME-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Drosophila melanogaster)
REACT:R-XTR-2179407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Xenopus tropicalis)
REACT:R-HSA-166220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FA anion diffuses laterally to UCP (Homo sapiens)
REACT:R-SCE-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Saccharomyces cerevisiae)
RHEA:27957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + presilphiperfolan-8beta-ol
RHEA:47225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:28952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-arabinose(in) => H(+)(out) + L-arabinose(out)
GO:0047470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity
GO:0047470	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malto-oligosyltrehalose synthase activity
GO:0047470	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	maltodextrin alpha-D-glucosyltransferase activity
GO:0047470	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase
RHEA:50014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropane-1,2-diol + H2O + NADP(+) => H(+) + NADPH + O2 + tert-butanol
REACT:R-CFA-201457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP2 binds to the receptor complex (Canis familiaris)
GO:0047419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine-6-phosphate deacetylase activity
REACT:R-MMU-1614631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homocysteine is degraded to oxobutanoate and H2S (Mus musculus)
RHEA:64011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine
REACT:R-PFA-5682388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophagosome maturation (Plasmodium falciparum)
REACT:R-XTR-5684864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Xenopus tropicalis)
REACT:R-MMU-914008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Mus musculus)
REACT:R-BTA-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Bos taurus)
RHEA:16940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycerol + ATP <=> 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-DRE-9630923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappa-B inhibitor binds NF-kappa-B complex (Danio rerio)
REACT:R-SSC-2730868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEK7 by MEKK1 (Sus scrofa)
GO:0019206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleoside kinase activity
RHEA:36922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA
REACT:R-SSC-8869603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A13 transports NCA from extracellular region to cytosol (Sus scrofa)
RHEA:19443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-cis,cis-muconate + 2 H(+) => benzene-1,2,4-triol + O2
REACT:R-BTA-5357432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXL binds SRC-1 (Bos taurus)
RHEA:72063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoursodeoxycholate(out) + 2 Na(+)(out) = glycoursodeoxycholate(in) + 2 Na(+)(in)
REACT:R-RNO-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Rattus norvegicus)
REACT:R-DRE-8863471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDLR is bound by DAB2 and ARH (Danio rerio)
GO:0098633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	collagen fibril binding
REACT:R-CEL-169904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3G stimulates nucleotide exchange on Rap1 (Caenorhabditis elegans)
REACT:R-MMU-159358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A3,4 dimers sulfate DA to DAOS (Mus musculus)
RHEA:34829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+) => H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2
REACT:R-MMU-9640254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Mus musculus)
REACT:R-SSC-5684882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHEK1 is recruited to resected DNA DSBs (Sus scrofa)
RHEA:24627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-threonine + tRNA(Thr) <=> AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)
REACT:R-SSC-164832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase synthesizes ATP (Sus scrofa)
REACT:R-GGA-5683964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates EYA1-4 (Gallus gallus)
REACT:R-SCE-6787329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2:Mg2+ isomerises R1P to R5P (Saccharomyces cerevisiae)
RHEA:21893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinose + NADP(+) => D-arabinono-1,4-lactone + H(+) + NADPH
REACT:R-RNO-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Rattus norvegicus)
RHEA:24732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aniline + CO2 => anthranilate + H(+)
REACT:R-CFA-9708517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Canis familiaris)
REACT:R-HSA-168951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR1:TLR2 is recruited to ligand:CD14 (Homo sapiens)
REACT:R-SSC-9013004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the ER membrane (Sus scrofa)
REACT:R-DME-214953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Full-length SNK is cleaved by GD serine protease (Drosophila melanogaster)
RHEA:13863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylono-1,5-lactone + H(+) + NADH => D-xylose + NAD(+)
REACT:R-CFA-8950724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Canis familiaris)
REACT:R-PFA-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Plasmodium falciparum)
REACT:R-SCE-9684118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC3-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)
REACT:R-XTR-173545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Xenopus tropicalis)
GO:0004876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	complement component C3a receptor activity
GO:0004876	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C3a anaphylatoxin receptor activity
RHEA:54544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine
REACT:R-CFA-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Canis familiaris)
REACT:R-XTR-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Xenopus tropicalis)
REACT:R-BTA-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Bos taurus)
REACT:R-XTR-2187358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMEPA1 sequesters unphosphorylated SMAD2/3 (Xenopus tropicalis)
RHEA:18265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) = 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH
RHEA:18265	skos:prefLabel	"6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase"
RHEA:18265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase"
RHEA:18933	skos:prefLabel	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase"
RHEA:18933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase"
RHEA:18933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O
RHEA:18933	skos:altLabel	"D-3-hydroxyacyl-CoA dehydratase"
RHEA:55686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate + H2O => chorismate + NH4(+)
RHEA:67663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-HSA-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Homo sapiens)
REACT:R-XTR-8867047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 dephosphorylates EPS15 (Xenopus tropicalis)
GO:0008176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity
GO:0008176	skos:altLabel	"N(7)-methylguanine methylase"
GO:0008176	skos:prefLabel	"tRNA (guanine(46)-N(7))-methyltransferase"
GO:0008176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	7-methylguanine transfer ribonucleate methylase activity
GO:0008176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (guanine(46)-N(7))-methyltransferase"
GO:0008176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine
GO:0008176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity
GO:0008176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA (guanine-N7-)-methyltransferase activity
GO:0008176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transfer ribonucleate guanine 7-methyltransferase activity
GO:0008176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N7-methylguanine methylase activity
GO:0008176	skos:altLabel	"tRNA guanine 7-methyltransferase"
GO:0008176	skos:altLabel	"tRNA (m(7)G(46)) methyltransferase"
GO:0008176	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA guanine 7-methyltransferase activity
GO:0008176	skos:altLabel	"tRNA (m7G46)-methyltransferase"
RHEA:46193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:46493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)
REACT:R-HSA-171141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Homo sapiens)
REACT:R-GGA-571318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoubiquitination of oligoTRAF6 bound to p-IRAK2  (Gallus gallus)
REACT:R-SPO-6807866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the ERGIC (Schizosaccharomyces pombe)
REACT:R-BTA-170861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimeric TGF-beta-1 binds to the receptor (Bos taurus)
REACT:R-HSA-1855186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 transports from the cytosol to the ER lumen (Homo sapiens)
RHEA:49834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + 2 H(+) + NADH => a fatty aldehyde + H2O + NAD(+)
REACT:R-CFA-2066788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Canis familiaris)
REACT:R-CFA-9640175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Canis familiaris)
REACT:R-RNO-3209165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ID1 sequesters ETS2 (Rattus norvegicus)
REACT:R-RNO-4608854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 are recruited to the DVL2:PARD6A complex (Rattus norvegicus)
REACT:R-XTR-5654167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds PLCG1 (Xenopus tropicalis)
RHEA:12843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + pyridoxal => pyridoxamine + pyruvate
RHEA:18832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + NAD(+) <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH
RHEA:43196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-163549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex (Homo sapiens)
REACT:R-DRE-5625738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Danio rerio)
RHEA:38701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O
RHEA:50625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O => a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)
REACT:R-HSA-6801776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A binds bacterial phospholipids (Homo sapiens)
REACT:R-CFA-9707586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FeHM oxidises LDL,HDL (Canis familiaris)
REACT:R-RNO-8948139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S13-FUNDC1 is dephosphorylated by PGAM5 (Rattus norvegicus)
REACT:R-XTR-426464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Xenopus tropicalis)
RHEA:32666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine <=> 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine
RHEA:61691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-threonine <=> AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]
RHEA:39335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)
GO:0015333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide:hydrogen symporter activity
GO:0015333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide:proton symporter activity
REACT:R-MMU-6811504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 dephosphorylation by PP2A-B56-beta,gamma (Mus musculus)
REACT:R-DDI-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Dictyostelium discoideum)
REACT:R-MMU-9691621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5 binds C5 inhibitors (Mus musculus)
RHEA:22118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP => luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate
REACT:R-HSA-170126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin B1 in the CRS domain (Homo sapiens)
RHEA:20045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H2O + NAD(+) = 2 H(+) + malonate + NADH
RHEA:61101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-376141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of ABL with ROBO1:SLIT2 (Caenorhabditis elegans)
RHEA:45298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + H(+) + phosphocholine => a sphingosylphosphocholine + H2O
RHEA:10741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + NAD(+) => a ketone + H(+) + NADH
RHEA:72684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate(out) => cholate(in)
REACT:R-HSA-8938487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-20a binds RUNX1 mRNA (Homo sapiens)
RHEA:46508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADH + nitrobenzene + O2 = catechol + NAD(+) + nitrite
GO:0052856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADHX epimerase activity
REACT:R-RNO-2247513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1:ligand is endocytosed (Rattus norvegicus)
REACT:R-GGA-8851908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds GAB1 (Gallus gallus)
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 6-phosphokinase activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phosphofructokinase reduction
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-fructose-6-phosphate 1-phosphotransferase activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phosphofructokinase activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphofructokinase (phosphorylating)
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent phosphofructokinase activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-fructose-6-phosphate 1-phosphotransferase activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphofructokinase I activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nucleotide triphosphate-dependent phosphofructokinase activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fructose 6-phosphate kinase activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-phosphofructose 1-kinase activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphohexokinase activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospho-1,6-fructokinase activity
GO:0003872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PFK
REACT:R-DME-8847534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43 hydrolyses GTP (Drosophila melanogaster)
REACT:R-GGA-5672980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of RAS:RAF complex (Gallus gallus)
RHEA:12445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanal + NADP(+) => (2E)-hexadecenal + H(+) + NADPH
RHEA:60717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-chrysanthemal + H2O + NADP(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADPH
RHEA:18669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H2O = adenine + D-ribose
RHEA:18669	skos:altLabel	"adenosinase"
RHEA:18669	skos:prefLabel	"adenosine nucleosidase"
RHEA:18669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosine nucleosidase"
GO:0071936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt signaling pathway
GO:0071936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Wnt co-receptor activity
GO:0071936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt-activated signaling pathway
GO:0071936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt receptor signalling pathway
GO:0071936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coreceptor activity involved in Wnt receptor signaling pathway
RHEA:22218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+) => (E)-caffeate + O2
REACT:R-XTR-9013108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOC (Xenopus tropicalis)
RHEA:65654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine
REACT:R-CFA-2484965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII binds Integrin alpha1beta1 (Canis familiaris)
REACT:R-CFA-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)
RHEA:21574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO + H(+) + N-acetylanthranilate => 3-hydroxy-2-methyl-1H-quinolin-4-one + O2
REACT:R-MMU-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Mus musculus)
REACT:R-BTA-5695964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD14B hydrolyses PNPB (Bos taurus)
RHEA:19115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+) => (8Z,11Z,14Z)-heptadecatrienal + A + H2O
RHEA:40151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
RHEA:12599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-acetylphosphinothricin => acetyl-CoA + phosphinothricin
RHEA:36790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine <=> N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
REACT:R-SCE-6809764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SBF1 binds MTMR2 (Saccharomyces cerevisiae)
REACT:R-BTA-4332236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL neddylates TGFBR2 (Bos taurus)
REACT:R-CFA-5624473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Canis familiaris)
GO:0102652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity
REACT:R-MMU-3777112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Mus musculus)
REACT:R-DRE-936991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Danio rerio)
RHEA:14716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + keto-L-sorbose <=> 5-dehydro-D-fructose + AH2
RHEA:28441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]
REACT:R-MMU-8949178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Mus musculus)
REACT:R-SPO-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)
GO:0047327	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity
GO:0047327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate-glucose phosphotransferase activity
RHEA:47951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + thiamine phosphate <=> phosphate + thiamine
REACT:R-CFA-2046087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of tetracosahexaenoyl-CoA to peroxisomes (Canis familiaris)
REACT:R-CFA-1638845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CERK phosphorylates CERA to form C1P (Canis familiaris)
RHEA:25541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate => diphosphate + ent-pimara-8(14),15-diene
REACT:R-DRE-1482932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Danio rerio)
REACT:R-DME-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)
EC:2.1.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Methyltransferases"
EC:2.1.1.-	skos:prefLabel	"Methyltransferases"
REACT:R-XTR-5693551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BRCA1-A complex at multiple sites by ATM (Xenopus tropicalis)
RHEA:41896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]
RHEA:15709	skos:altLabel	"F3GalTase"
RHEA:15709	skos:prefLabel	"kaempferol 3-O-galactosyltransferase"
RHEA:15709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"kaempferol 3-O-galactosyltransferase"
RHEA:15709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + UDP-alpha-D-galactose = H(+) + kaempferol 3-O-beta-D-galactoside + UDP
REACT:R-DRE-2161195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Danio rerio)
REACT:R-HSA-4088305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXM1 stimulates PLK1 transcription (Homo sapiens)
RHEA:16854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(1,2-dicarboxyethyl)-AMP => AMP + fumarate
REACT:R-BTA-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Bos taurus)
RHEA:15391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP + diphosphate => ATP
REACT:R-XTR-5656064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 binds FLRT1,2,3 (Xenopus tropicalis)
REACT:R-SSC-6804762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 forms homotetramers (Sus scrofa)
REACT:R-MMU-8875817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates STAT3 (Mus musculus)
RHEA:45372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(9Z-octadecenoyl)-sphinganine = (9Z)-octadecenoate + sphinganine
REACT:R-GGA-2132133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5b:C6:C7 inserts into the target cell membrane (Gallus gallus)
RHEA:24538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-formyl-L-kynurenine => L-tryptophan + O2
REACT:R-DME-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Drosophila melanogaster)
REACT:R-CFA-8964619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 binds ARHGEF6 (Canis familiaris)
RHEA:18829	skos:altLabel	"4PE dehydrogenase"
RHEA:18829	skos:altLabel	"4-O-phosphoerythronate dehydrogenase"
RHEA:18829	skos:altLabel	"erythronate-4-phosphate dehydrogenase"
RHEA:18829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH
RHEA:18829	skos:prefLabel	"4-phosphoerythronate dehydrogenase"
RHEA:18829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-phosphoerythronate dehydrogenase"
GO:0051959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dynein light intermediate chain binding
GO:0140814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine:sodium:chloride symporter activity
GO:0140814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) = 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)
GO:0140814	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium/chloride-dependent glycine betaine transporter activity
EC:1.1.1.329	skos:prefLabel	"2-deoxy-scyllo-inosamine dehydrogenase"
EC:1.1.1.329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-deoxy-scyllo-inosamine dehydrogenase"
REACT:R-BTA-76052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIA To type 1 Promoter (Bos taurus)
GO:0061675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rhamnose-binding lectin family protein binding
GO:0061675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBL family protein binding
RHEA:62539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]
GO:0102673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty aldehyde dehydrogenase activity
RHEA:41885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-XTR-917835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from holoTF:TFRC dimer (Xenopus tropicalis)
REACT:R-DME-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Drosophila melanogaster)
REACT:R-SPO-114553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of conventional Protein Kinase C (Schizosaccharomyces pombe)
REACT:R-HSA-4085083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Homo sapiens)
RHEA:10892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-isopropylmalate + NAD(+) = (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH
REACT:R-RNO-8852266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Rattus norvegicus)
EC:3.4.22.34	skos:altLabel	"phaseolin"
EC:3.4.22.34	skos:altLabel	"bean endopeptidase"
EC:3.4.22.34	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"legumain"
EC:3.4.22.34	skos:altLabel	"asparaginyl endopeptidase"
EC:3.4.22.34	skos:altLabel	"vicilin peptidohydrolase"
EC:3.4.22.34	skos:altLabel	"hemoglobinase"
EC:3.4.22.34	skos:prefLabel	"legumain"
REACT:R-RNO-8951500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of CANX from nonameric complex (Rattus norvegicus)
REACT:R-BTA-3000433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PML with SUMO3 (Bos taurus)
RHEA:38586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate
RHEA:40384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)
RHEA:32652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	erythromycin D + S-adenosyl-L-methionine => erythromycin B + H(+) + S-adenosyl-L-homocysteine
EC:1.16.-.-	skos:prefLabel	"Oxidizing metal ions"
EC:1.16.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Oxidizing metal ions"
RHEA:69564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine = 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O
REACT:R-DRE-8944242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVII (Danio rerio)
RHEA:28480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactarate(out) + H(+)(out) => galactarate(in) + H(+)(in)
RHEA:45519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]
RHEA:35300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH
REACT:R-CEL-8854303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D11 binds RAB6 (Caenorhabditis elegans)
REACT:R-BTA-8948027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEs bind bacterial phospholipids (Bos taurus)
REACT:R-GGA-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Gallus gallus)
RHEA:39194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-docosenoyl-CoA + H(+) + NADPH <=> docosanoyl-CoA + NADP(+)
REACT:R-MMU-8957265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades TP73 polyubiquitinated by ITCH (Mus musculus)
RHEA:67799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotidyl-ribonucleotide-RNA <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA
REACT:R-CEL-5693681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DUOX1,2 reduce O2 to H2O2 (Caenorhabditis elegans)
GO:0008192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA guanylyltransferase activity
REACT:R-BTA-6799495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYCTK phosphorylates DGA to 3PDGA (Bos taurus)
REACT:R-DRE-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Danio rerio)
RHEA:64597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)
REACT:R-RNO-8869627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NR to yield NMN (Rattus norvegicus)
REACT:R-MMU-170861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimeric TGF-beta-1 binds to the receptor (Mus musculus)
REACT:R-HSA-6798615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the TP53AIP1 gene (Homo sapiens)
REACT:R-DME-74247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes hypoxanthine to form xanthine (Drosophila melanogaster)
REACT:R-DME-5694423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE complex (Drosophila melanogaster)
REACT:R-CFA-141186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
REACT:R-CFA-166753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C4 into C4a and C4b (Canis familiaris)
REACT:R-CFA-5653936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Ragulator complex (Canis familiaris)
RHEA:16900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxysteroid + a triacylglycerol <=> a 3beta-hydroxysteroid ester + a diacylglycerol
RHEA:49964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine + O2 = H2O2 + phenazine
RHEA:66385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesol => scalar-17(25)-en-19-ol
REACT:R-DRE-8849969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)
REACT:R-CFA-77263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Canis familiaris)
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminyltransferase V activity
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity
GO:0030144	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GnTV activity
REACT:R-CFA-9617067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Canis familiaris)
REACT:R-MMU-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Mus musculus)
RHEA:21397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) => CO2 + Na(+)(out) + propanoyl-CoA
RHEA:67538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine => (9Z,12Z)-octadecadienoyl-CoA + H2O
REACT:R-GGA-1227863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IRF to activated TBK1/IKK epsilon (Gallus gallus)
REACT:R-HSA-9769177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 stimulates PLK2 gene expression (Homo sapiens)
RHEA:51265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 columbamine + O2 => 2 berberine + 2 H2O
GO:0019531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate transmembrane transporter activity
GO:0019531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalic acid transporter activity
REACT:R-HSA-5607757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-TRAF6 ubiquitinates TAK1 (Homo sapiens)
REACT:R-BTA-1614461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tetramerization of procollagen VI (Bos taurus)
RHEA:19335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + formyl-CoA => H(+) + oxalyl-CoA
RHEA:49520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate
RHEA:49520	skos:prefLabel	"mRNA N(6)-methyladenine demethylase"
RHEA:49520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mRNA N(6)-methyladenine demethylase"
RHEA:30563	skos:altLabel	"7-DMATS"
RHEA:30563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + L-tryptophan = 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate
RHEA:30563	skos:prefLabel	"7-dimethylallyltryptophan synthase"
RHEA:30563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-dimethylallyltryptophan synthase"
RHEA:39131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA
RHEA:60109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-(4-hydroxyphenyl)lactoyl-CoA => (E)-4-coumaroyl-CoA + H2O
REACT:R-GGA-5693551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of BRCA1-A complex at multiple sites by ATM (Gallus gallus)
REACT:R-SPO-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Schizosaccharomyces pombe)
RHEA:41874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxydodecanoyl-[ACP] + NADP(+) => 3-oxododecanoyl-[ACP] + H(+) + NADPH
GO:0005179	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lipopeptide hormone
GO:0005179	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glycopeptide hormone
GO:0005179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hormone activity
GO:0005179	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cAMP generating peptide activity
GO:0005179	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peptide hormone
REACT:R-RNO-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Rattus norvegicus)
RHEA:68388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 H2O + 2 indole-5,6-quinone-2-carboxylate
RHEA:47015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsrC protein]-disulfide + H(+) + hydrogen sulfide <=> [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled D-methionine transporter activity
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine-importing ATPase activity
GO:0033232	skos:altLabel	"methionine ABC transporter"
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type D-methionine transporter activity
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine-transporting ATPase activity
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methionine transmembrane-transporting ATPase activity
GO:0033232	skos:prefLabel	"ABC-type methionine transporter"
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine importer
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine transporter activity
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine exporter
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine-exporting ATPase activity
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type methionine transporter"
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-methionine transmembrane transporter activity
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent methionine transmembrane transporter activity
GO:0033232	skos:altLabel	"methionine transporting ATPase"
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-methionine(out) = ADP + H(+) + L-methionine(in) + phosphate
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled methionine transmembrane transporter activity
GO:0033232	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent D-methionine transporter activity
REACT:R-GGA-1980125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH binds DTX (Gallus gallus)
RHEA:20638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + D-glucose => D-glucono-1,5-lactone + D-sorbitol
RHEA:71362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) <=> 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)
RHEA:22983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] <=> a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]
RHEA:18597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 reduced [rubredoxin] = NADH + 2 oxidized [rubredoxin]
GO:0001099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	basal RNA polymerase II transcription machinery binding
GO:0001099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	basal RNAP II transcription machinery binding
REACT:R-MMU-352107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Mus musculus)
RHEA:58034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]
GO:0102676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	avenasterol-desaturase activity
RHEA:65434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+) => a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate
RHEA:15563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sterigmatocystin
REACT:R-HSA-8869694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds CD14 (Homo sapiens)
GO:0140036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitin-dependent protein binding
REACT:R-BTA-997326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Bos taurus)
RHEA:13532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-citramalate <=> H2O + mesaconate
REACT:R-HSA-2161946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5S-HpETE is reduced to 5S-HETE by GPX1/2/4 (Homo sapiens)
REACT:R-CFA-8870352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A4 transports L-Trp from extracellular region to cytosol (Canis familiaris)
RHEA:26053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:70888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-serine(out) + Na(+)(out) => L-glutamine(out) + L-serine(in) + Na(+)(in)
REACT:R-GGA-8878787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPI dimer hydrolyses phosphate monoesters (Gallus gallus)
RHEA:44437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol
REACT:R-HSA-111524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Homo sapiens)
RHEA:18567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine => 19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine
RHEA:70383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-3-oxosphinganine
REACT:R-BTA-139898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 activates BID by cleavage (Bos taurus)
GO:0047199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine-dolichol O-acyltransferase activity
GO:0047199	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-sn-phosphatidylcholine:dolichol O-acyltransferase activity
REACT:R-SSC-8875374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET binds LRIG1 (Sus scrofa)
REACT:R-BTA-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Bos taurus)
RHEA:70599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
RHEA:31567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisphenol A + H(+) + NADH + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)
RHEA:38962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + O2 <=> a (2E)-enoyl-CoA + H2O2
RHEA:43653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + CoA
REACT:R-HSA-9023859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Estrogen-responsive TFF1 gene expression (Homo sapiens)
REACT:R-BTA-4568848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Bos taurus)
REACT:R-BTA-1855176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Bos taurus)
GO:0102179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-ethylidenelophenol 4alpha-methyl oxidase activity
GO:0008020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein-coupled photoreceptor activity
GO:0008020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein coupled photoreceptor activity
GO:0008020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein coupled photoreceptor activity
GO:0008020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	photoreceptor activity, G-protein coupled
GO:0036505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prosaposin-activated receptor activity
GO:0036505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prosaposin receptor activity
RHEA:29449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycolate(out) => glycolate(in)
REACT:R-DRE-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Danio rerio)
REACT:R-HSA-433104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NACT co-transports trivalent citrate and a sodium ion (Homo sapiens)
RHEA:60320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-CFA-2995388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates BANF1 (Canis familiaris)
RHEA:39241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + triacontanoyl-CoA => (2E)-triacontenoyl-CoA + H(+) + NADPH
RHEA:32399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,2R,4S)-neodihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH
REACT:R-BTA-8940561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP7 cleaves OPTC (Bos taurus)
REACT:R-HSA-212642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-Glutamine transport into neurons (Homo sapiens)
RHEA:19747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + L-thyroxine => 3,3',5-triiodo-L-thyronine + A + H(+) + iodide
REACT:R-MMU-77068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GT (Mus musculus)
REACT:R-DDI-8876193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1-RGP1 exchanges GTP for GDP on RAB6 (Dictyostelium discoideum)
RHEA:43001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate
RHEA:55195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 <=> 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate
RHEA:63349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-amino acyl-L-cysteinyl-[protein] => (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate
RHEA:66577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 4-isopropylphenol => 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)
REACT:R-CEL-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)
REACT:R-SSC-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Sus scrofa)
REACT:R-RNO-194689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
GO:0016697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a cytochrome as acceptor"
GO:0016697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor
GO:0016697	skos:prefLabel	"With a cytochrome as acceptor"
GO:0015021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparin-sulphate lyase activity
GO:0015021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin-sulfate eliminase activity
GO:0015021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparitinase II
GO:0015021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparitinase I
GO:0015021	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[heparan sulfate]-sulfate lyase activity
GO:0015021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparitin-sulfate lyase activity
GO:0015021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparin-sulfate lyase activity
REACT:R-SSC-76500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBXAS1 isomerises PGH2 to TXA2 (Sus scrofa)
RHEA:58384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octan-1-ol = H(+) + NADPH + octanal
REACT:R-CFA-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Canis familiaris)
REACT:R-RNO-5694494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)
REACT:R-CFA-3928592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Canis familiaris)
RHEA:33262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminoimidazole + H(+) + 2 H2O <=> N-formimidoylglycine + NH4(+)
RHEA:18433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexylamine oxidase"
RHEA:18433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexylamine + H2O + O2 = cyclohexanone + H2O2 + NH4(+)
RHEA:18433	skos:prefLabel	"cyclohexylamine oxidase"
REACT:R-MMU-388981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Kiss receptor GPR54 binds kisspeptin (Mus musculus)
GO:0099102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential
RHEA:43750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + hexacosanoyl-CoA => ATP + CoA + hexacosanoate
REACT:R-DDI-264418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of COP1 from the nucleus to the cytoplasm (Dictyostelium discoideum)
RHEA:67097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + asnovolin A + 2 O2 => CO2 + fumigatonoid A + succinate
RHEA:14619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-glutathione + H(+) + NADPH => CoA + glutathione + NADP(+)
RHEA:37001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:37656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:33871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + H2O = glyoxylate + NH4(+) + urea
REACT:R-RNO-3244643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds cyclic GMP-AMP (Rattus norvegicus)
RHEA:25153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-phenylalanine => 3-phenylpyruvate + L-glutamate
REACT:R-CFA-8953339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNPH1 hydrolyses dGMP (Canis familiaris)
RHEA:25297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde + H2O + NAD(+) <=> acetate + 2 H(+) + NADH
REACT:R-CFA-9649732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mature S-Farn-Me KRAS4B translocates to plasma membrane (Canis familiaris)
REACT:R-RNO-1247668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin A binds O2, releasing H+ and CO2 (Rattus norvegicus)
RHEA:14725	skos:altLabel	"ATP:corrinoid adenosyltransferase"
RHEA:14725	skos:altLabel	"aquacob(I)alamin adenosyltransferase"
RHEA:14725	skos:prefLabel	"corrinoid adenosyltransferase"
RHEA:14725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate
RHEA:14725	skos:altLabel	"aquocob(I)alamin vitamin B12s adenosyltransferase"
RHEA:14725	skos:altLabel	"cob(I)alamin adenosyltransferase"
RHEA:14725	skos:altLabel	"cob(I)yrinic acid a,c-diamide adenosyltransferase"
RHEA:14725	skos:altLabel	"ATP:cob(I)alamin Cobeta-adenosyltransferase"
RHEA:14725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"corrinoid adenosyltransferase"
RHEA:38678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
REACT:R-RNO-5244669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Rattus norvegicus)
REACT:R-XTR-390593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP Hydrolysis By Myosin (Xenopus tropicalis)
RHEA:49835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty aldehyde + H2O + NAD(+) <=> a fatty acid + 2 H(+) + NADH
REACT:R-CFA-2730664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Canis familiaris)
REACT:R-SCE-6809778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Saccharomyces cerevisiae)
RHEA:23138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a methylated primary amine + H(+) + S-adenosyl-L-homocysteine => a primary amine + S-adenosyl-L-methionine
RHEA:14479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]
GO:0034596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4)P-phosphatase activity
GO:0034596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoinositide 4-phosphatase activity
GO:0034596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol phosphate 4-phosphatase activity
GO:0034596	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	inositol 4-phosphatase
GO:0034596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P-phosphatase activity
GO:0034596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtdIns4P-phosphatase activity
REACT:R-DDI-9610153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Dictyostelium discoideum)
REACT:R-MMU-179417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Multiubiquitination of Nek2A (Mus musculus)
RHEA:63459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + CTP <=> (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)
RHEA:11002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-D-amino acid + 2 H(+) + H2O
RHEA:28678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose <=> beta-D-galactose
RHEA:65755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-glutamate + O2 <=> (3R)-3-hydroxy-L-glutamate + CO2 + succinate
EC:3.2.2.9	skos:altLabel	"5'-methyladenosine nucleosidase"
EC:3.2.2.9	skos:altLabel	"AdoHcy/MTA nucleosidase"
EC:3.2.2.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylhomocysteine nucleosidase"
EC:3.2.2.9	skos:prefLabel	"adenosylhomocysteine nucleosidase"
EC:3.2.2.9	skos:altLabel	"S-adenosylhomocysteine hydrolase"
EC:3.2.2.9	skos:altLabel	"S-adenosylhomocysteine nucleosidase"
EC:3.2.2.9	skos:altLabel	"S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase"
REACT:R-DDI-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Dictyostelium discoideum)
REACT:R-XTR-5683714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCA3 transports PC, PG from ER membrane to lamellar body (Xenopus tropicalis)
REACT:R-DME-2514865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cGMP dissociates from CNG channels (Drosophila melanogaster)
REACT:R-SSC-5682586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HERC2 and PIAS4 are recruited to DNA DSBs (Sus scrofa)
RHEA:62261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + Mn(2+)(out) => 2 hydrogencarbonate(in) + Mn(2+)(in)
RHEA:70414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetyl-CoA + H2O <=> 4-hydroxyphenylacetate + CoA + H(+)
REACT:R-BTA-3222116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L3MBTL1 binds TP53 monomethylated on K382 (Bos taurus)
RHEA:20025	skos:prefLabel	"gibberellin beta-D-glucosyltransferase"
RHEA:20025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gibberellin beta-D-glucosyltransferase"
RHEA:20025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A3 + UDP-alpha-D-glucose = gibberellin A3 O-beta-D-glucoside + H(+) + UDP
RHEA:50130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1
GO:0015379	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	potassium ion symporter activity
GO:0015379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	potassium:chloride symporter activity
REACT:R-GGA-8869506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)
RHEA:58453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-SSC-9009936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEL cleaves cellular ssRNA (Sus scrofa)
REACT:R-MMU-9707505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemes bind to CLEC1B dimer (Mus musculus)
RHEA:64569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => ilicicolin H
REACT:R-GGA-6814695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PERP binds desmosomes (Gallus gallus)
REACT:R-SCE-428273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK1 phosphorylates SPG to S1P (Saccharomyces cerevisiae)
REACT:R-CFA-5205661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pink1 is recruited from the cytoplasm to the mitochondria (Canis familiaris)
REACT:R-HSA-170964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 binds to active TrkA receptor (Homo sapiens)
RHEA:17713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salutaridine synthase"
RHEA:17713	skos:altLabel	"(R)-reticuline oxidase (C-C phenol-coupling)"
RHEA:17713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine
RHEA:17713	skos:prefLabel	"salutaridine synthase"
REACT:R-BTA-8869206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Bos taurus)
REACT:R-RNO-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Rattus norvegicus)
REACT:R-XTR-9611839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β3-agonists bind ADRB3 (Xenopus tropicalis)
RHEA:28298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(E)-gamma-bisabolene synthase"
RHEA:28298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate
RHEA:28298	skos:prefLabel	"(E)-gamma-bisabolene synthase"
REACT:R-RNO-192425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)
REACT:R-HSA-9731590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)
REACT:R-MMU-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Mus musculus)
REACT:R-HSA-9010641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKAP5 recruits PKA to ROBO2 (Homo sapiens)
REACT:R-XTR-4615900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB2 with SUMO3 (Xenopus tropicalis)
RHEA:46933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-epi-5-epi-valiolone 7-phosphate => 5-epi-valiolone 7-phosphate
REACT:R-HSA-8852331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 translocates to the nucleus (Homo sapiens)
RHEA:67982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydro-beta-carotene => beta-zeacarotene
GO:0140664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent DNA damage sensing activity
GO:0140664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent DNA damage sensor activity
GO:0000992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase III cis-regulatory region sequence-specific DNA binding
REACT:R-GGA-8849348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Gallus gallus)
REACT:R-RNO-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Rattus norvegicus)
REACT:R-SPO-8948146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUNDC1 is phosphorylated by ULK1 at Ser17 (Schizosaccharomyces pombe)
REACT:R-XTR-5218826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Xenopus tropicalis)
RHEA:48771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-erythrulose <=> ADP + D-erythrulose 4-phosphate + H(+)
RHEA:57803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dinitrotoluene + NADH + O2 <=> 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite
REACT:R-HSA-5649873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)
RHEA:68451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-lycopene + O2 <=> (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal
REACT:R-GGA-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Gallus gallus)
RHEA:71870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycodeoxycholate(out) <=> glycodeoxycholate(in)
REACT:R-HSA-110376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Homo sapiens)
RHEA:55665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 AH2 + echinenone + 2 O2 => 2 A + canthaxanthin + 3 H2O
RHEA:43168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)
RHEA:43168	skos:prefLabel	"tRNA(adenine(34)) deaminase"
RHEA:43168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(adenine(34)) deaminase"
REACT:R-DRE-5607742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Danio rerio)
REACT:R-XTR-5220959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-formylcytosine (Xenopus tropicalis)
GO:0009381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	excinuclease ABC activity
REACT:R-DRE-3318486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Danio rerio)
RHEA:50746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 aminomethylphosphonate + 2 glyoxylate + 2 H(+) => 2 glyphosate + O2
RHEA:65457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-1-ol + acetyl-CoA => 2-methylbutyl acetate + CoA
REACT:R-XTR-5655483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP1 autocleavage (Xenopus tropicalis)
REACT:R-RNO-8867044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EPS15, EPN1, EPS15L1 (Rattus norvegicus)
REACT:R-XTR-266070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4 is exported from the cytosol by ABCC1 (Xenopus tropicalis)
RHEA:51806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + H(+) + lupulone => deoxyhumulone + dimethylallyl diphosphate
REACT:R-CFA-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Canis familiaris)
REACT:R-DME-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
RHEA:55704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide
RHEA:55704	skos:prefLabel	"sulfide-dependent adenosine diphosphate thiazole synthase"
RHEA:55704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sulfide-dependent adenosine diphosphate thiazole synthase"
REACT:R-DRE-5617828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIP11:IFT20 dissociates (Danio rerio)
REACT:R-DRE-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Danio rerio)
RHEA:46794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
RHEA:12238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxynicotinate + H(+) + NADPH => H2O + NADP(+) + nicotinate
RHEA:29802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-allose(out) + H2O <=> ADP + D-allose(in) + H(+) + phosphate
RHEA:56604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)
RHEA:47902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate => ganglioside GM3 (d18:1(4E)) + H2O
REACT:R-HSA-448632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimerizes (Homo sapiens)
REACT:R-RNO-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Rattus norvegicus)
REACT:R-DME-6783221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Drosophila melanogaster)
RHEA:42290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] => 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine
GO:0047870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-dimethylallyladenine + S-adenosyl-L-methionine = discadenine + H(+) + S-methyl-5'-thioadenosine
GO:0047870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	discadenine synthetase activity
GO:0047870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity
GO:0047870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	discadenine synthase activity
GO:0047870	skos:prefLabel	"discadenine synthase"
GO:0047870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"discadenine synthase"
GO:0047870	skos:altLabel	"discadenine synthetase"
GO:0047870	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas
REACT:R-BTA-6814187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVL:PPL heterodimer binds the inner surface of the plasma membrane (Bos taurus)
REACT:R-SSC-2029457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cross-linking of FCGRIIIA with IgG-coated Ag (Sus scrofa)
REACT:R-XTR-9626817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates NCF1 (Xenopus tropicalis)
GO:0071886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-iodo-2,5-dimethoxyphenylisopropylamine binding
GO:0071886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
GO:0071886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding
GO:0071886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding
REACT:R-GGA-975608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP2:atROL and FACYLs to atREs (Gallus gallus)
REACT:R-SSC-6805122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB binds TP53 (Sus scrofa)
REACT:R-MMU-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Mus musculus)
GO:0047844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycytidine deaminase activity
GO:0047844	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidine aminohydrolase activity
REACT:R-SSC-4084980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Sus scrofa)
RHEA:62549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP
REACT:R-BTA-197268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)
REACT:R-CFA-202307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Change of PKC theta conformation (Canis familiaris)
REACT:R-XTR-216757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Xenopus tropicalis)
RHEA:31289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acryloyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA
REACT:R-RNO-6805035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds STK11 and NUAK1 (Rattus norvegicus)
RHEA:55442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:25492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(4S)-beta-phellandrene synthase (geranyl-diphosphate-cyclizing)"
RHEA:25492	skos:prefLabel	"(4S)-beta-phellandrene synthase (geranyl-diphosphate-cyclizing)"
RHEA:25492	skos:altLabel	"(-)-beta-phellandrene synthase"
RHEA:25492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = (-)-beta-phellandrene + diphosphate
RHEA:25492	skos:altLabel	"(-)-(4S)-beta-phellandrene synthase"
REACT:R-DRE-9638120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU4 hydrolyses Neu5Ac from glycoconjugates (Danio rerio)
RHEA:56579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer + H(+) + UDP
RHEA:55002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine
REACT:R-XTR-429613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-HSA-879459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F-actin capping protein is a heterodimer (Homo sapiens)
REACT:R-GGA-388808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD28 homodimer binds B7-2 monomer (Gallus gallus)
REACT:R-SSC-913675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GALNTs transfer GalNAc to Mucins to form Tn antigens (Sus scrofa)
REACT:R-BTA-9023840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HATs and coactivators are recruited to the CTSD gene (Bos taurus)
REACT:R-DME-446278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RhBG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)
RHEA:13335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 2-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O
RHEA:46705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + salicylate => 2-hydroxybenzoyl-5'-AMP + diphosphate
REACT:R-CFA-1467269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins bind microbial membranes causing disruption (Canis familiaris)
REACT:R-RNO-449976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)
REACT:R-RNO-113402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:early elongation complex (Rattus norvegicus)
REACT:R-RNO-73788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Rattus norvegicus)
RHEA:29518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)
REACT:R-RNO-158546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGTs glucuronate APAP to APAP-GlcA (Rattus norvegicus)
REACT:R-SSC-1306965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Sus scrofa)
RHEA:72936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(out) + 2 Na(+)(out) => (S)-lactate(in) + 2 Na(+)(in)
RHEA:68366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+) => 4-CDP-2-C-methyl-D-erythritol
REACT:R-SSC-5358579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase delta polymerizes DNA across single stranded gap (Sus scrofa)
REACT:R-SSC-159773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein S to protein S (Sus scrofa)
RHEA:68035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cystathionine ketimine + 2 H(+) + NADH <=> (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)
REACT:R-DME-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Drosophila melanogaster)
RHEA:27861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-GMP + H2O <=> 3'-GMP + H(+)
REACT:R-MMU-373087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor CCR6 binds CCL20 ligand (Mus musculus)
REACT:R-BTA-4411383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLK phosphorylates TCF/LEF (Bos taurus)
RHEA:71656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O => a thymidine in DNA + ADP-D-ribose
REACT:R-DME-2066778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)
REACT:R-CFA-977375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR1 binds C3bBb/C4bC2a (Canis familiaris)
REACT:R-MMU-9796387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Mus musculus)
RHEA:23694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + maleate => (R)-malate
REACT:R-HSA-4570489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NOP58 with SUMO2 (Homo sapiens)
GO:0033434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATC codon-amino acid adaptor activity
GO:0033434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUC codon-amino acid adaptor activity
GO:0033434	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoleucine tRNA
RHEA:54191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-phenylalanine <=> acetate + L-phenylalanine
RHEA:16036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + gibberellin A44 + O2 <=> CO2 + gibberellin A19 + H2O + succinate
GO:0080146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate
GO:0080146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine desulfhydrase activity
REACT:R-RNO-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Rattus norvegicus)
REACT:R-CEL-741449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Caenorhabditis elegans)
EC:2.6.1.13	skos:altLabel	"ornithine--oxo acid aminotransferase"
EC:2.6.1.13	skos:prefLabel	"ornithine aminotransferase"
EC:2.6.1.13	skos:altLabel	"ornithine--keto acid transaminase"
EC:2.6.1.13	skos:altLabel	"ornithine delta-transaminase"
EC:2.6.1.13	skos:altLabel	"ornithine--2-oxoacid aminotransferase"
EC:2.6.1.13	skos:altLabel	"ornithine transaminase"
EC:2.6.1.13	skos:altLabel	"ornithine 5-aminotransferase"
EC:2.6.1.13	skos:altLabel	"ornithine ketoacid aminotransferase"
EC:2.6.1.13	skos:altLabel	"L-ornithine aminotransferase"
EC:2.6.1.13	skos:altLabel	"L-ornithine 5-aminotransferase"
EC:2.6.1.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ornithine aminotransferase"
EC:2.6.1.13	skos:altLabel	"ornithine--keto acid aminotransferase"
EC:2.6.1.13	skos:altLabel	"ornithine--ketoglutarate aminotransferase"
EC:2.6.1.13	skos:altLabel	"ornithine--alpha-ketoglutarate aminotransferase"
EC:2.6.1.13	skos:altLabel	"ornithine--oxo-acid transaminase"
RHEA:62445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-canavanine + L-ornithine => H(+) + L-arginine + L-canaline
REACT:R-HSA-9007582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
REACT:R-CFA-5624492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK phosphorylates p21 RAF1 on S338 (Canis familiaris)
RHEA:21398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + Na(+)(out) + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in)
RHEA:43901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)
RHEA:65925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine => 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine
GO:0140806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+- protein-aspartate ADP-ribosyltransferase activity
RHEA:72342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) <=> catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
RHEA:22005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[myosin light chain] => ADP + H(+) + O-phospho-L-seryl-[myosin light chain]
RHEA:65545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM1 + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc
REACT:R-XTR-873927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of STAT1 dimer from active receptor unit (Xenopus tropicalis)
RHEA:54383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> 5-hydroxy-alpha-gurjunene + diphosphate
REACT:R-BTA-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Bos taurus)
REACT:R-SPO-9696274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds GTP (Schizosaccharomyces pombe)
REACT:R-XTR-2530445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD59 inhibits MAC formation (Xenopus tropicalis)
GO:0050594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tabersonine 16-hydroxylase activity
GO:0050594	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)
GO:0050594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0050594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tabersonine 16-hydroxylase"
GO:0050594	skos:altLabel	"tabersonine-11-hydroxylase"
GO:0050594	skos:prefLabel	"tabersonine 16-hydroxylase"
GO:0050594	skos:altLabel	"CYP71D12"
RHEA:67608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP
RHEA:64515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine
REACT:R-BTA-193758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Bos taurus)
RHEA:58196	skos:prefLabel	"histone deacetylase"
RHEA:58196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"histone deacetylase"
RHEA:58196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]
RHEA:58196	skos:altLabel	"HDAC"
REACT:R-CFA-193737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Canis familiaris)
REACT:R-MMU-1222491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lactoferrin scavenges iron ions (Mus musculus)
EC:3.6.1.21	skos:prefLabel	"ADP-sugar diphosphatase"
EC:3.6.1.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ADP-sugar diphosphatase"
EC:3.6.1.21	skos:altLabel	"ADP-sugar pyrophosphatase"
REACT:R-PFA-75172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of RAD50:MRE11 complex (Plasmodium falciparum)
RHEA:59767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-HSA-9035227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXN2 binds CysS248-MPST (Homo sapiens)
RHEA:68080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)
GO:0017162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aryl hydrocarbon receptor binding
REACT:R-BTA-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Bos taurus)
REACT:R-GGA-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Gallus gallus)
RHEA:49571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-en-1-ol <=> (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione
REACT:R-HSA-9702589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gilteritinib-resistant FLT3 mutants don't bind gilteritinib (Homo sapiens)
RHEA:68798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + D-glucose => D-maltose + H2O
REACT:R-MMU-1675836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Mus musculus)
REACT:R-SSC-5674130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Sus scrofa)
RHEA:61365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dehydroepiandrosterone 3-sulfate(in) + H2O => ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate
REACT:R-GGA-2186771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 binds SMAD7 (Gallus gallus)
RHEA:64285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylethylamine + pyruvate => 2-phenylacetaldehyde + L-alanine
REACT:R-DME-75010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser 216 by Chk1 (Drosophila melanogaster)
RHEA:55720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate
RHEA:72710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose(in) + GMP(out) <=> GDP-beta-L-fucose(out) + GMP(in)
RHEA:40140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + H2O => (9Z)-octadecenoate + CoA + H(+)
REACT:R-DRE-5336443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIN7, CASK and APBA1 bind (Danio rerio)
RHEA:30581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine + phosphate => H2O + O-phospho-L-threonine
REACT:R-HSA-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)
REACT:R-DRE-8850539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of GNB5:RGS dimers from CCT/TRiC (Danio rerio)
RHEA:33642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + tetracosanoate <=> AMP + diphosphate + tetracosanoyl-CoA
REACT:R-CFA-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Canis familiaris)
REACT:R-HSA-9724745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLG(20-810) binds aprotinin (Homo sapiens)
REACT:R-BTA-5690911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1:4Fe-4S isomerises CIT to ISCIT (Bos taurus)
REACT:R-DRE-1676206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Danio rerio)
RHEA:63332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-arabinopyanose = beta-L-arabinopyranose
RHEA:44976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + propanoyl-CoA = CoA + O-propanoyl-(R)-carnitine
REACT:R-MMU-2317314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT binds PDPK1 (Mus musculus)
REACT:R-MMU-9036307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPER:Heterotrimeric G-protein Gs binds ESTG (Mus musculus)
REACT:R-CFA-5685953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT6 deacetylates RBBP8 (Canis familiaris)
REACT:R-CFA-888592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Canis familiaris)
GO:0010945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA pyrophosphatase activity
GO:0010945	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	conezyme A pyrophosphatase activity
REACT:R-GGA-216064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha8beta1 with Tenascin-C (Gallus gallus)
REACT:R-HSA-204773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb7 (Homo sapiens)
REACT:R-SCE-68917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)
REACT:R-BTA-1678660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan sulfate chain(3) (Bos taurus)
RHEA:40102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
REACT:R-CFA-8937631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Canis familiaris)
RHEA:51684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"farnesyl phosphate kinase"
RHEA:51684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl phosphate + CTP = (2E,6E)-farnesyl diphosphate + CDP
RHEA:51684	skos:prefLabel	"farnesyl phosphate kinase"
RHEA:29338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-glutamate <=> L-alanine + L-glutamate
RHEA:25309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin + phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O
REACT:R-HSA-593690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLCgamma by Netrin-1 (Homo sapiens)
REACT:R-CFA-158468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT1A1 dimer sulfonates PARA to PARA-SO4 (Canis familiaris)
REACT:R-XTR-5675431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates RAF1 (Xenopus tropicalis)
RHEA:54896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,15Z)-12-oxophytodienoate + ATP + CoA = (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate
REACT:R-SSC-8849032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS2 (Sus scrofa)
RHEA:28731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-leucine(in) = H(+)(in) + L-leucine(out)
REACT:R-RNO-400434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FFAR1 binds fatty acids (Rattus norvegicus)
REACT:R-SCE-6814831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D20 binds RAB1:GTP (Saccharomyces cerevisiae)
REACT:R-DDI-947499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exchange of oxygen with sulfur in MoCo (Dictyostelium discoideum)
REACT:R-SSC-8931981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ESR1 (Sus scrofa)
RHEA:18594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate => hexadecanal + phosphoethanolamine
RHEA:17602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribulose => ADP + D-ribulose 5-phosphate + H(+)
REACT:R-BTA-77587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Docking of Mature Replication Dependent Histone mRNA with the NPC (Bos taurus)
RHEA:53979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
RHEA:20314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP => 1D-myo-inositol hexakisphosphate + ADP + H(+)
RHEA:66537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cholest-4,6-dien-3-one + H2O => 25-hydroxycholest-4,6-dien-3-one + AH2
RHEA:52865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)
REACT:R-XTR-189421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPO transforms COPRO3 to PPGEN9 (Xenopus tropicalis)
RHEA:47201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-7alpha-dihydroxycholesterol + NAD(+) => (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH
REACT:R-CFA-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Canis familiaris)
REACT:R-DME-9709454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPOR binds EPOR agonists (Drosophila melanogaster)
REACT:R-RNO-8856157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAG3 (CD233) binds MHC II (Rattus norvegicus)
RHEA:72723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-xylose(in) + UMP(out) = UDP-alpha-D-xylose(out) + UMP(in)
REACT:R-RNO-389523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTLA interacts with HVEM (Rattus norvegicus)
REACT:R-MMU-9638090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)
RHEA:48490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal--[retinol-binding protein] + H(+) + NADH => all-trans-retinol--[retinol-binding protein] + NAD(+)
RHEA:40606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)
REACT:R-MTU-879245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycothiol binds formaldehyde and is dehydrogenated (Mycobacterium tuberculosis)
RHEA:48430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-glycerol + H2O
REACT:R-CEL-9018756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds GTP (Caenorhabditis elegans)
REACT:R-XTR-444773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGF-TM7 receptors bind chondroitin sulphate (Xenopus tropicalis)
RHEA:62370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(in) + 2 hydrogencarbonate(in) => Fe(2+)(out) + 2 hydrogencarbonate(out)
REACT:R-CFA-5682769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI2 binds ADAM22,23 (Canis familiaris)
RHEA:27849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)
REACT:R-DRE-5099886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binding to FZD promotes PRICKLE1 degradation (Danio rerio)
REACT:R-GGA-9724685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds omalizumab (Gallus gallus)
REACT:R-DRE-8877153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 binds PC (Danio rerio)
RHEA:14399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z)-2-oxohept-4-enedioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)
RHEA:41490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine
RHEA:68454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone => all-trans-10'-apo-beta-carotenal + O2
RHEA:41667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrochelirubine + NAD(+) <=> chelirubine + NADH
RHEA:30213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide => 2 Fe(III)-[cytochrome c] + H2O + nitrous oxide
REACT:R-CFA-5696670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD1L is recruited to GG-NER site (Canis familiaris)
REACT:R-CFA-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Canis familiaris)
REACT:R-XTR-1307955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds HS:KLB:FGF19 (Xenopus tropicalis)
REACT:R-RNO-9009488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 binds CSF1 (Rattus norvegicus)
RHEA:58512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)
RHEA:37884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + oxalate => acetate + oxalyl-CoA
REACT:R-CFA-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Canis familiaris)
RHEA:35561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-7 + NAD(+) => H(+) + menaquinone-7 + NADH
GO:0005091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanyl-nucleotide exchange factor adaptor activity
GO:0103116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent alpha-D-galactofuranose transporter activity
GO:0103116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactofuranose transporter activity
GO:0103116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type D-galactofuranose transporter
GO:0103116	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled alpha-D-galactofuranose transporter activity
RHEA:23624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH
RHEA:40256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexadecenedioyl-CoA + H2O => (3R)-hydroxyhexadecanedioyl-CoA
REACT:R-CFA-8964246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in G alpha (12)-BTK complex is activated (Canis familiaris)
RHEA:29959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose = alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
RHEA:62171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiose <=> acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine
REACT:R-SCE-5683925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 is dephosphorylated (Saccharomyces cerevisiae)
RHEA:18664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) <=> H(+) + L-ornithine + NADPH + pyruvate
REACT:R-HSA-9699579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO3 downstream of FLT3  (Homo sapiens)
REACT:R-BTA-9011543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCA binds PDK2 (Bos taurus)
REACT:R-DME-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)
RHEA:72372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + succinate(in) => dehydroepiandrosterone 3-sulfate(in) + succinate(out)
REACT:R-BTA-8877998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Bos taurus)
REACT:R-GGA-8987039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL20RA (Gallus gallus)
REACT:R-CFA-202724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-selectin binds P-selectin ligand (Canis familiaris)
RHEA:28697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(out) => hydrogencarbonate(in)
REACT:R-CFA-9614564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins bind AKT-phosphorylated FOXO4 (Canis familiaris)
RHEA:62323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-isomalbrancheamide B + FADH2
REACT:R-BTA-901047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERp57 (Bos taurus)
RHEA:43337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) => CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)
REACT:R-HSA-9673756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)
REACT:R-DME-975185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Drosophila melanogaster)
REACT:R-SSC-2509838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA hydrolyses dITP to dIMP (Sus scrofa)
RHEA:21184	skos:altLabel	"dolichol-phosphate mannose synthase"
RHEA:21184	skos:altLabel	"mannosylphosphoryldolichol synthase"
RHEA:21184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyl-phosphate beta-D-mannosyltransferase"
RHEA:21184	skos:altLabel	"dolichol-phosphate mannosyltransferase"
RHEA:21184	skos:altLabel	"mannosylphosphodolichol synthase"
RHEA:21184	skos:prefLabel	"dolichyl-phosphate beta-D-mannosyltransferase"
RHEA:21184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl phosphate + GDP-alpha-D-mannose = a dolichyl beta-D-mannosyl phosphate + GDP
RHEA:28066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
RHEA:67380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-cysteine = L-alanine + L-cysteine
REACT:R-SSC-9670114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H3.3 deposition at telomere (Sus scrofa)
RHEA:41085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-BTA-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)
REACT:R-RNO-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Rattus norvegicus)
REACT:R-CEL-1482691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)
REACT:R-CEL-426240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG kinase produces phosphatidic acid from DAG (Caenorhabditis elegans)
REACT:R-GGA-6786097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3, p-Y641-STAT6 dimerise (Gallus gallus)
REACT:R-CFA-420592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transhomodimerization of Nectin-like (Necl) proteins (Canis familiaris)
RHEA:51160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-372819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Dictyostelium discoideum)
REACT:R-CEL-380782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT binds to the active receptor (Caenorhabditis elegans)
REACT:R-DRE-5218821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK1 phosphorylates PKC (Danio rerio)
REACT:R-BTA-9710354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSDME (1-270) binds cardiolipin (Bos taurus)
REACT:R-BTA-199803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xylulose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)
REACT:R-DDI-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Dictyostelium discoideum)
RHEA:28997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-threonine(out) => H(+)(out) + L-threonine(in)
REACT:R-BTA-5693783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAALADases hydrolyse NAAG (Bos taurus)
RHEA:72579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA
RHEA:46629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH => androst-5-en-3beta,17beta-diol + NADP(+)
REACT:R-CEL-9013145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds effectors at the plasma membrane (Caenorhabditis elegans)
REACT:R-XTR-3928576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds ROCK, activating it (Xenopus tropicalis)
REACT:R-DRE-437085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZnT5 transports zinc into secretory granules in pancreatic beta cells (Danio rerio)
REACT:R-BTA-8850356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds microbial lipid-based antigen via CD1 (Bos taurus)
REACT:R-RNO-2046084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Rattus norvegicus)
REACT:R-CFA-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
RHEA:56660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
RHEA:56660	skos:altLabel	"3-oxo-choloyl-CoA dehydrogenase"
RHEA:56660	skos:prefLabel	"3-oxocholoyl-CoA 4-desaturase"
RHEA:56660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-oxocholoyl-CoA 4-desaturase"
RHEA:56660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH
RHEA:52695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenyllactate + NADP(+) <=> 3-phenylpyruvate + H(+) + NADPH
RHEA:20970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-L-arabinonate + H2O => L-arabinonate
REACT:R-DRE-6783530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gp130:JAKs bind CNTFR (Danio rerio)
RHEA:65038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
RHEA:67689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O => 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate
RHEA:36327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate
REACT:R-BTA-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Bos taurus)
RHEA:66332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate(out) = L-aspartate(in)
REACT:R-BTA-8875568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 activates RAP1 (Bos taurus)
REACT:R-HSA-2396009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds c-di-GMP (Homo sapiens)
REACT:R-HSA-8849428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 binds PTK6 (Homo sapiens)
RHEA:26420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2
REACT:R-HSA-5218836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2beta binds alphaVbeta3 (Homo sapiens)
RHEA:66392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + prostaglandin E1(in) = ADP + H(+) + phosphate + prostaglandin E1(out)
REACT:R-HSA-915148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Correctly folded glycoproteins translocate to the Golgi (Homo sapiens)
REACT:R-RNO-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Rattus norvegicus)
REACT:R-DRE-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Danio rerio)
RHEA:23725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pyridoxal => 4-pyridoxate + H(+) + H2O2
REACT:R-CEL-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Caenorhabditis elegans)
RHEA:34389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose
RHEA:52261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1),7(1)-dihydroxybacteriochlorophyllide c => a bacteriochlorophyllide e + H2O
REACT:R-DRE-173488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The SMAD2/3:SMAD4 complex transfers to the nucleus (Danio rerio)
RHEA:60228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate
REACT:R-HSA-201717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK2-mediated phosphorylation of DVL (Homo sapiens)
GO:0010295	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)
GO:0010295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-abscisic acid 8'-hydroxylase activity
GO:0010295	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(+)-ABA 8'-hydroxylase activity
GO:0010295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abscisic acid 8'-hydroxylase activity
GO:0010295	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ABA 8'-hydroxylase activity
GO:0010295	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity
RHEA:66607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in double-stranded DNA + NH4(+)
RHEA:42860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate
REACT:R-GGA-158781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Gallus gallus)
REACT:R-SSC-5649681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL2 cleaves 5-OHU from damaged DNA (Sus scrofa)
RHEA:15627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-6A + H(+) + NADH => Co-precorrin-6B + NAD(+)
REACT:R-DME-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)
REACT:R-XTR-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Xenopus tropicalis)
RHEA:35544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphooxypyruvate + H2O => 3-hydroxypyruvate + phosphate
REACT:R-MMU-174157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cyclin B (Mus musculus)
REACT:R-CEL-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Caenorhabditis elegans)
GO:0033872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity
GO:0033872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity
GO:0033872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin-glucosamine 3-sulfotransferase 3 activity
GO:0033872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity
GO:0033872	skos:altLabel	"heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3"
GO:0033872	skos:altLabel	"3-OST-3"
GO:0033872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[heparan sulfate]-glucosamine 3-sulfotransferase 3"
GO:0033872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-OST-3
GO:0033872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)
GO:0033872	skos:altLabel	"glucosaminyl 3-O-sulfotransferase 3"
GO:0033872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosaminyl 3-O-sulfotransferase 3 activity
GO:0033872	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity
GO:0033872	skos:prefLabel	"[heparan sulfate]-glucosamine 3-sulfotransferase 3"
GO:0033872	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glucosaminyl 3-O-sulfotransferase 3a, 3b activity
REACT:R-SSC-422051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the signal peptide of Preproghrelin (Sus scrofa)
REACT:R-CEL-727767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Caenorhabditis elegans)
REACT:R-DME-6814088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYS1 binds AcM-ARFRP1 (Drosophila melanogaster)
REACT:R-CEL-5666104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Caenorhabditis elegans)
REACT:R-XTR-1855218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Xenopus tropicalis)
REACT:R-DME-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Drosophila melanogaster)
REACT:R-HSA-8952382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 polyubiquitinates RUNX3 (Homo sapiens)
REACT:R-HSA-5693742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAAH hydrolyses AEA to AA and ETA (Homo sapiens)
REACT:R-GGA-8849345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Gallus gallus)
REACT:R-RNO-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Rattus norvegicus)
REACT:R-DME-8854628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLIP dimer ubiquitinates VLDLR on Lys-839 (Drosophila melanogaster)
REACT:R-MMU-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)
REACT:R-CEL-9648983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Caenorhabditis elegans)
REACT:R-DME-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Drosophila melanogaster)
REACT:R-RNO-1363306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p130 (RBL2) binds Cyclin E/A:CDK2 (Rattus norvegicus)
REACT:R-MMU-163096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Telomerase RNP to the Telomeric Chromosome End (Mus musculus)
REACT:R-HSA-419232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
REACT:R-SSC-5692408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPR2 binds NPPC (Sus scrofa)
EC:1.14.14.73	skos:altLabel	"albendazole hydroxylase"
EC:1.14.14.73	skos:altLabel	"CYP1A2"
EC:1.14.14.73	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"albendazole monooxygenase (sufoxide-forming)"
EC:1.14.14.73	skos:altLabel	"albendazole sulfoxidase"
EC:1.14.14.73	skos:altLabel	"CYP3A4"
EC:1.14.14.73	skos:prefLabel	"albendazole monooxygenase (sufoxide-forming)"
EC:1.14.14.73	skos:altLabel	"CYP2J2"
REACT:R-MMU-191999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Mus musculus)
RHEA:41797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine
REACT:R-HSA-4341070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates PPARA with SUMO1 (Homo sapiens)
RHEA:24795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine
REACT:R-SSC-1614336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Sus scrofa)
REACT:R-DDI-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Dictyostelium discoideum)
RHEA:54328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + hexadecanoyl-[ACP] + 2 NADPH = hexadecan-1-ol + holo-[ACP] + 2 NADP(+)
REACT:R-CFA-9029987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S216-CDC25C translocates to the cytosol (Canis familiaris)
RHEA:13246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate => glyoxylate + succinate
REACT:R-HSA-8934446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PKC phosphorylates SHC1 (Homo sapiens)
RHEA:54932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] = (2E,9Z)-hexadecadienoyl-[ACP] + H2O
RHEA:16134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(1)-acetylspermine + O2 => 3-aminopropanal + H2O2 + N(1)-acetylspermidine
REACT:R-HSA-156661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Exon Junction Complex (Homo sapiens)
RHEA:67232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH
REACT:R-SSC-976810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to extracellular Factor H:C3b (Sus scrofa)
REACT:R-BTA-5607002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C cleaves factor VIIIa (Bos taurus)
REACT:R-CFA-199910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates ATF1 (Canis familiaris)
RHEA:70033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]
RHEA:56050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein 7-O-beta-D-glucoside + UDP => daidzein + UDP-alpha-D-glucose
REACT:R-BTA-211950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 24-hydroxylates CTL (Bos taurus)
REACT:R-GGA-517536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Gallus gallus)
REACT:R-CEL-417890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y5 receptor can bind to LPA (Caenorhabditis elegans)
RHEA:55653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
RHEA:67109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine
RHEA:35605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + phosphate => beta-D-fructose 1-phosphate + H2O
REACT:R-SSC-8964605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Sus scrofa)
REACT:R-HSA-9615945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160  (Homo sapiens)
EC:4.2.1.6	skos:prefLabel	"galactonate dehydratase"
EC:4.2.1.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactonate dehydratase"
REACT:R-DME-198508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDH1 catalyzes the conversion of malate to oxaloacetate (Drosophila melanogaster)
REACT:R-GGA-8951966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EP300 acetylates RUNX3 (Gallus gallus)
REACT:R-HSA-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Homo sapiens)
RHEA:36455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanylglycine(out) = ADP + H(+) + L-alanylglycine(in) + phosphate
REACT:R-BTA-5229273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCN2:2,5DHBA binds Fe3+ (Bos taurus)
REACT:R-DME-203946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDK isoforms phosphorylate lipo-PDH (Drosophila melanogaster)
REACT:R-GGA-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Gallus gallus)
REACT:R-XTR-917888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apoTF binds 2Fe3+ to form holoTF (Xenopus tropicalis)
RHEA:25762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate <=> diphosphate + ent-isokaurene
REACT:R-XTR-210285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homophilic interaction of PECAM-1 (Xenopus tropicalis)
RHEA:28602	skos:altLabel	"CYP79D3"
RHEA:28602	skos:altLabel	"CYP79D4"
RHEA:28602	skos:prefLabel	"isoleucine N-monooxygenase"
RHEA:28602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isoleucine N-monooxygenase"
RHEA:28602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)
REACT:R-HSA-204981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3epsilon attentuates NADE-related apoptosis (Homo sapiens)
RHEA:63696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D-glucuronide + UDP
RHEA:63671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH
REACT:R-BTA-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Bos taurus)
RHEA:62041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(octanoyl)-sphing-4-enine-1-phosphate => N-octanoylsphing-4-enine + phosphate
RHEA:17496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + glycerol <=> AH2 + dihydroxyacetone
REACT:R-XTR-8952716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 binds Ragulator:Rag dimers (Xenopus tropicalis)
REACT:R-HSA-9698016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)
RHEA:44930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-trihomocitrate + CoA + H(+) => 2-oxoheptanedioate + acetyl-CoA + H2O
REACT:R-BTA-9708466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y486 BACH1 translocates from the nucleoplasm to the cytosol (Bos taurus)
REACT:R-CEL-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Caenorhabditis elegans)
REACT:R-SSC-5251989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A4,5 transport divalent ions from extracellular region to cytosol (Sus scrofa)
REACT:R-HSA-448728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19 binds IL20RA:JAK1:IL20RB (Homo sapiens)
RHEA:14514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine => ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate
RHEA:25141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2-oxopropyl phosphate + CO2 => (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+)
REACT:R-SPO-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Schizosaccharomyces pombe)
REACT:R-SSC-73591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Sus scrofa)
RHEA:24237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-[cytochrome c] + H2O + trimethylamine => 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide
RHEA:34957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(methylsulfanyl)-D-ribose(out) => 5-(methylsulfanyl)-D-ribose(in)
RHEA:51447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine
REACT:R-HSA-73794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)
REACT:R-SPO-446208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a second mannose to the N-glycan precursor by ALG2 (Schizosaccharomyces pombe)
RHEA:71340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-tyrosine(out) + 2 Na(+)(out) => chloride(in) + L-tyrosine(in) + 2 Na(+)(in)
RHEA:50651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O
REACT:R-SPO-3341294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Superoxide reduces cytochrome c (Schizosaccharomyces pombe)
REACT:R-HSA-8849748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The COG complex binds RABs at the Golgi membrane (Homo sapiens)
GO:0016509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LCHAD
GO:0016509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxyacyl-CoA dehydrogenase activity
GO:0016509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity
GO:0016509	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity
REACT:R-SSC-159567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSM2B-like proteins transform ST to ST-CoA (Sus scrofa)
REACT:R-DRE-8865237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD6 methylates RELA in the NFkB complex (Danio rerio)
REACT:R-CFA-9700200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)
REACT:R-GGA-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Gallus gallus)
REACT:R-HSA-8955030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK2 dimer phosphorylates NAD+ to NADP+ (Homo sapiens)
REACT:R-HSA-211272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein (Homo sapiens)
RHEA:52687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + pyridoxine <=> H(+) + NADH + pyridoxal
REACT:R-SSC-6782628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates STAM2:HGS (Sus scrofa)
REACT:R-HSA-3321805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSL acetylates histone H4 (Homo sapiens)
REACT:R-BTA-70654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Bos taurus)
RHEA:47397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanoate ester => an aliphatic alcohol + H(+) + octadecanoate
REACT:R-DDI-8955760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Dictyostelium discoideum)
REACT:R-DRE-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Danio rerio)
REACT:R-GGA-2507854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Gallus gallus)
REACT:R-RNO-8854255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D2A accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)
REACT:R-HSA-167484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fall Back to Closed Pre-initiation Complex (Homo sapiens)
GO:0015631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin binding
GO:0047000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxy-D-gluconate dehydrogenase activity
GO:0047000	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity
GO:0047000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity
REACT:R-XTR-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Xenopus tropicalis)
REACT:R-SPO-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Schizosaccharomyces pombe)
REACT:R-CFA-443439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-Src binds Raf1 (Canis familiaris)
REACT:R-HSA-964737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)
REACT:R-MMU-5213466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is phosphorylated (Mus musculus)
RHEA:13763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-homocysteine + S-methyl-L-methionine => L-methionine + S-adenosyl-L-methionine
REACT:R-BTA-917933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Bos taurus)
RHEA:49107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester
RHEA:59840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + syringate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate
RHEA:25173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine
RHEA:43686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate
REACT:R-MMU-5651657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Mus musculus)
RHEA:25354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteinyl-tRNA(Pro) <=> H(+) + L-cysteine + tRNA(Pro)
REACT:R-GGA-8851038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTN3A1 binds prenylated phosphoantigens (Gallus gallus)
RHEA:16099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + pyruvate => acetylpyruvate + H2O
REACT:R-HSA-1855154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
RHEA:49947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate <=> (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate
GO:0004252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	blood coagulation factor activity
GO:0004252	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serine elastase activity
GO:0004252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serine-type endopeptidase activity
GO:0019164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvic-ferredoxin oxidoreductase activity
GO:0019164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate-ferredoxin reductase activity
GO:0019164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate oxidoreductase activity
GO:0019164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PFOR
GO:0019164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)
GO:0019164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate synthetase activity
GO:0019164	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyruvate:ferredoxin oxidoreductase activity
GO:0019164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate synthase activity
RHEA:53193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
REACT:R-DRE-5653974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator binds Rag dimers (Danio rerio)
RHEA:19347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate
REACT:R-SSC-2730892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV to p-SLP-76 (Sus scrofa)
REACT:R-RNO-5693977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Rattus norvegicus)
REACT:R-HSA-76052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIA To type 1 Promoter (Homo sapiens)
RHEA:69290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate + sulforaphane => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate
REACT:R-MMU-8848930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 translocates to the nucleus (Mus musculus)
REACT:R-DME-5654623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 binds FRS3 (Drosophila melanogaster)
REACT:R-DRE-8852552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MST1R autophosphorylates (Danio rerio)
REACT:R-DME-380927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-AMPK phosphorylates TSC1:TSC2 (Drosophila melanogaster)
REACT:R-SSC-198513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Sus scrofa)
REACT:R-MMU-140825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Mus musculus)
RHEA:55236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)
REACT:R-CEL-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Caenorhabditis elegans)
RHEA:70664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(in) + H(+)(in) => 4-hydroxy-L-proline(out) + H(+)(out)
REACT:R-MMU-2213201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of collagen fibres (Mus musculus)
RHEA:15659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylcatechol + CO2 + NADH => 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+)
RHEA:36004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-4-hydroxy-2-oxohexanoate => propanal + pyruvate
REACT:R-HSA-2404134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP4:atROL binds TTR (Homo sapiens)
REACT:R-MMU-3000434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Mus musculus)
GO:0047348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphoglycerol pyrophosphorylase activity
GO:0047348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol-3-phosphate cytidylyltransferase activity
GO:0047348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:glycerol-3-phosphate cytidylyltransferase activity
GO:0047348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-glycerol diphosphorylase activity
GO:0047348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine diphosphate glycerol pyrophosphorylase activity
GO:0047348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Gro-PCT
GO:0047348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CDP-glycerol pyrophosphorylase activity
GO:0047348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:glycerol 3-phosphate cytidylyltransferase activity
GO:0047348	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:sn-glycerol-3-phosphate cytidylyltransferase activity
REACT:R-CFA-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Canis familiaris)
RHEA:72470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA <=> 6 CO2 + 8 CoA + H2O + o-orsellinate depside
REACT:R-CEL-381111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Caenorhabditis elegans)
REACT:R-SSC-70899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histidine => urocanate + NH4+ (Sus scrofa)
REACT:R-XTR-879528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO2A1 transports PGT substrates from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-HSA-9006050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2:SIN3A complex binds the promoter of the BDNF gene (Homo sapiens)
REACT:R-CEL-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Caenorhabditis elegans)
REACT:R-SSC-917807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Sus scrofa)
RHEA:68896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + ATP + H(+) + NADPH = 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)
REACT:R-DME-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Drosophila melanogaster)
REACT:R-RNO-5625796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM4C binds KLK2 and KLK3 promoters (Rattus norvegicus)
REACT:R-CFA-5690042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)
REACT:R-HSA-9017988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRH gene expression is repressed by MECP2 (Homo sapiens)
REACT:R-SSC-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Sus scrofa)
REACT:R-DRE-5694583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD4 hydrolyses NAPE (Danio rerio)
REACT:R-GGA-4546387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates VDR with SUMO2 (Gallus gallus)
RHEA:27635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH
RHEA:16506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate => 4-hydroxybenzoate + pyruvate
REACT:R-MMU-5668731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX3 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)
REACT:R-CFA-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Canis familiaris)
GO:0034582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity
RHEA:40813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O
REACT:R-RNO-5678706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB4 transports PC from plasma membrane to extracellular region (Rattus norvegicus)
REACT:R-CFA-2682349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Canis familiaris)
REACT:R-SSC-977602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I binds to MCP, CR1:C4b, C3b (Sus scrofa)
RHEA:65861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + Delta(1)-dihydrotestosterone + H2O => 17beta-hydroxyandrostan-1,3-dione + AH2
REACT:R-HSA-186773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF dimer binds two receptors simultaneously (Homo sapiens)
RHEA:42502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)
RHEA:55796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + phenol = H2O + hydroquinone + NAD(+)
RHEA:17019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA
REACT:R-GGA-202710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MERTK receptor binds ligands (Gas6 or Protein S) (Gallus gallus)
GO:0090488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polo box domain specific binding
RHEA:35734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycerol 3-phosphate + tetradecanoyl-CoA <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA
RHEA:15737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclopentanone + H(+) + NADPH + O2 = 5-valerolactone + H2O + NADP(+)
RHEA:15737	skos:prefLabel	"cyclopentanone monooxygenase"
RHEA:15737	skos:altLabel	"Cyclopentanone 1,2-monooxygenase"
RHEA:15737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclopentanone monooxygenase"
RHEA:11582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + myo-inositol
RHEA:15112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + NADP(+) <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH
RHEA:46343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-hexadecanoylsphing-4-enine <=> ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate
REACT:R-GGA-9726875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCNs:cAMP bind SNIs (Gallus gallus)
REACT:R-CFA-5218838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXN binds p-6Y,S732-PTK2 (Canis familiaris)
REACT:R-HSA-5229132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP4 binds APP (Homo sapiens)
REACT:R-CEL-1504193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated DVL is degraded by the proteasome (Caenorhabditis elegans)
RHEA:12077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic primary alcohol + NAD(+) => an aromatic aldehyde + H(+) + NADH
RHEA:41566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aclacinomycin T + dTDP + 2 H(+) => aklavinone + dTDP-beta-L-rhodosamine
REACT:R-HSA-9027600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3 (Homo sapiens)
REACT:R-MMU-5082391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimerization of HSF1 in the nucleus (Mus musculus)
RHEA:34860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxocyclopentanecarbonitrile + 2 H2O => 3-oxocyclopentanecarboxylate + NH4(+)
RHEA:33720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)
REACT:R-HSA-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Homo sapiens)
REACT:R-DME-6786012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Drosophila melanogaster)
REACT:R-SSC-2574840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA facilitates AURKA autophosphorylation (Sus scrofa)
RHEA:13826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-rhamnose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH
RHEA:17391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose + H(+) + NADH => D-arabinitol + NAD(+)
REACT:R-DRE-2065355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)
RHEA:38185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-5660666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBP and p300 binds NF-kB complex (Homo sapiens)
RHEA:43359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl (9Z,12Z)-octadecadienoate(in) <=> cholesteryl (9Z,12Z)-octadecadienoate(out)
REACT:R-BTA-1474146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCH1 reduces GTP to dihydroneopterin triphosphate (Bos taurus)
RHEA:50887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O <=> (9Z-octadecenoyl)-glycerol + phosphate
REACT:R-DRE-74726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of insulin from insulin receptor (Danio rerio)
REACT:R-SSC-2032770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1 to the nucleus (Sus scrofa)
REACT:R-XTR-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Xenopus tropicalis)
REACT:R-SSC-965079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPNPO:2xFMN oxidizes PXAP to PXLP (Sus scrofa)
RHEA:36821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA
RHEA:54605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + decanoyl-CoA + O2 => 2-hydroxydecanoyl-CoA + CO2 + succinate
REACT:R-BTA-9731661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)
REACT:R-HSA-434637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
GO:0043830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiol-driven fumarate reductase activity
GO:0016765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring alkyl or aryl groups, other than methyl groups
GO:0016765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transferase activity, transferring alkyl or aryl (other than methyl) groups
RHEA:41223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-GGA-5422942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXRA:PPARD binds FABP5:atRA (Gallus gallus)
GO:0140683	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K9me2 demethylase activity
GO:0140683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-di/monomethyl-lysine-9 demethylase activity
GO:0140683	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K9me demethylase activity
GO:0140683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9me/H3K9me2 demethylase activity
RHEA:57793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dinitrotoluene + NADH + O2 => 4-methyl-6-nitrocatechol + NAD(+) + nitrite
RHEA:66450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-2-pentenal + H(+) + NADPH => (E)-pent-2-en-1-ol + NADP(+)
RHEA:40619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + tridodecanoylglycerol = 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)
RHEA:20200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparosan-N-sulfate](n) <=> [heparan-N-sulfate](n)
REACT:R-RNO-3371353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Soluble TNF-α binds TNFR1 (Rattus norvegicus)
REACT:R-XTR-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Xenopus tropicalis)
RHEA:24580	skos:prefLabel	"sorbitol-6-phosphatase"
RHEA:24580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sorbitol-6-phosphatase"
RHEA:24580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate
GO:0102952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity
GO:0102952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-coniferaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP
REACT:R-XTR-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Xenopus tropicalis)
RHEA:14830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogen sulfide + O-acetyl-L-serine => acetate + L-cysteine
REACT:R-CFA-8942099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Canis familiaris)
REACT:R-GGA-5655965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLK and POLZ cooperate in elongation of mispaired primer termini (Gallus gallus)
REACT:R-RNO-5252079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP110s exchange ATP for ADP on HSP70s:ADP (Rattus norvegicus)
RHEA:16126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-fructose => ADP + D-fructose 6-phosphate + H(+)
RHEA:53324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2
REACT:R-MMU-419003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Nectins with Afadin (Mus musculus)
REACT:R-MMU-3149518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRR reduces cob(II)alamin to meCbl (Mus musculus)
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid 20-22-lyase activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome p450(scc) activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome P-450scc
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol side-chain cleavage enzyme activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol desmolase activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol monooxygenase (side-chain-cleaving) activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	C27-side chain cleavage enzyme
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	desmolase, steroid 20-22
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol C(20-22) desmolase activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome p450scc
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol C20-22 desmolase activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P-450(scc) activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	steroid 20-22 desmolase activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol 20-22-desmolase activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Cyp11a1
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cholesterol side-chain-cleaving enzyme activity
GO:0008386	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	enzymes, cholesterol side-chain-cleaving
REACT:R-DRE-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)
REACT:R-RNO-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Rattus norvegicus)
REACT:R-DME-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Drosophila melanogaster)
RHEA:14132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH
RHEA:48358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
REACT:R-SSC-77609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of APOBEC-1 to form editosome (Sus scrofa)
REACT:R-DRE-159762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)
RHEA:68223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol <=> (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA
REACT:R-RNO-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Rattus norvegicus)
RHEA:53548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin J2 = Delta(12)-prostaglandin J2
EC:4.4.1.29	skos:prefLabel	"phycobiliprotein cysteine-84 phycobilin lyase"
EC:4.4.1.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phycobiliprotein cysteine-84 phycobilin lyase"
RHEA:64425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-leucyl-L-proline(out) => H(+)(in) + L-leucyl-L-proline(in)
REACT:R-CFA-3002798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PLK1 translocates to the nucleus (Canis familiaris)
REACT:R-HSA-8984012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Homo sapiens)
GO:0018672	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilate 2,3-dioxygenase (deaminating)
GO:0018672	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilate 2,3-hydroxylase (deaminating) activity
GO:0018672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate 3-monooxygenase (deaminating) activity
GO:0018672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate hydroxylase (deaminating) activity
GO:0018672	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	anthranilate hydroxylase activity
GO:0018672	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)
REACT:R-RNO-72669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Met-tRNAi binds to eIF2:GTP to form the ternary complex (Rattus norvegicus)
RHEA:72942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + propanoate(out) <=> 2 Na(+)(in) + propanoate(in)
REACT:R-SSC-8871260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD2 (Sus scrofa)
REACT:R-MMU-75822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Mus musculus)
REACT:R-CFA-8851089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase2 hydrolyzes nucleoside triphosphates (Canis familiaris)
RHEA:13992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
REACT:R-BTA-6782004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the pre-incision complex in TC-NER (Bos taurus)
REACT:R-HSA-1225961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)
RHEA:28911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-lysine(out) = H(+)(in) + L-lysine(in)
REACT:R-MMU-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Mus musculus)
RHEA:35795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine = H(+) + kanamycin A + UDP
RHEA:57818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-ribose 5-phosphate + guanine => dGMP + H2O
RHEA:30283	skos:altLabel	"pyrethroid-selective esterase"
RHEA:30283	skos:prefLabel	"pyrethroid hydrolase"
RHEA:30283	skos:altLabel	"pyrethroid-cleaving enzyme"
RHEA:30283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-trans-permethrin + H2O = (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)
RHEA:30283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyrethroid hydrolase"
RHEA:30283	skos:altLabel	"permethrinase"
RHEA:30283	skos:altLabel	"pyrethroid-hydrolyzing esterase"
RHEA:30283	skos:altLabel	"pyrethroid-hydrolyzing carboxylesterase"
REACT:R-CFA-1855174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)
REACT:R-RNO-5695989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAD11 dehydrogenates BH-CoA (Rattus norvegicus)
RHEA:12632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-hyoscyamine + O2 <=> (6S)-6-hydroxyhyoscyamine + CO2 + succinate
REACT:R-BTA-9668904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CTF18 complex (Bos taurus)
RHEA:59662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-cellotetraono-1,5-lactone + H2O2 => D-cellotetraose + O2
REACT:R-MMU-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Mus musculus)
RHEA:12679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin => AH2 + Latia luciferin + 2 O2
REACT:R-DRE-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Danio rerio)
REACT:R-MMU-170685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenylaye cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
GO:0015431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type glutathione-S-conjugate transporter"
GO:0015431	skos:altLabel	"YCF1 (gene name)"
GO:0015431	skos:altLabel	"multidrug resistance-associated protein 1"
GO:0015431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type glutathione S-conjugate transporter activity
GO:0015431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent glutathione S-conjugate export pump
GO:0015431	skos:altLabel	"YBT1 (gene name)"
GO:0015431	skos:prefLabel	"ABC-type glutathione-S-conjugate transporter"
GO:0015431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRP1/GS-X pump
GO:0015431	skos:altLabel	"glutathione-S-conjugate-translocating ATPase"
GO:0015431	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	glutathione S-conjugate-exporting ATPase activity
GO:0015431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate
GO:0015431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled glutathione S-conjugate transmembrane transporter activity
GO:0015431	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	conjugate transporter activity
GO:0015431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GS-X pump
GO:0015431	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutathione S-conjugate-transporting ATPase activity
REACT:R-HSA-5662603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1B binds zinc (Homo sapiens)
RHEA:21030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein] => acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein]
REACT:R-PFA-9755306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub UBXN7 is degraded by the 26S proteasome (Plasmodium falciparum)
REACT:R-CFA-6785607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCM binds FAAP24 (Canis familiaris)
REACT:R-RNO-1604712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP7 by trypsin (Rattus norvegicus)
REACT:R-SSC-351936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of claspin (Sus scrofa)
REACT:R-HSA-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)
RHEA:55648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + validoxylamine A = CO2 + H(+) + succinate + validoxylamine B
REACT:R-HSA-975594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLB1 hydrolyses RPALM to atROL (Homo sapiens)
RHEA:11779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-8940100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates VCPIP1 (Xenopus tropicalis)
REACT:R-CFA-2569057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP3 binds TRIF to mediate necroptosis (Canis familiaris)
REACT:R-HSA-188350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin E:Cdk2 (Homo sapiens)
GO:0047726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	iron-cytochrome c reductase activity
GO:0047726	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ferrocytochrome-c:Fe3+ oxidoreductase activity
GO:0047726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron-cytochrome-c reductase activity
REACT:R-DRE-451309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Edited Kainate Receptor binds glutamate (Danio rerio)
REACT:R-SSC-9760094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRXN1 reduces hyperoxidized PRDX1 dimer (Sus scrofa)
RHEA:52997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH => [eIF5A protein]-deoxyhypusine + NAD(+)
REACT:R-CFA-2029451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV (Canis familiaris)
RHEA:39199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxytetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O
RHEA:32096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)
REACT:R-RNO-9648114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)
REACT:R-RNO-6786012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Rattus norvegicus)
REACT:R-DDI-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Dictyostelium discoideum)
REACT:R-SSC-421831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Coat Assembly (Sus scrofa)
RHEA:16378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-DME-1358790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates ERBB3 (Drosophila melanogaster)
REACT:R-BTA-4568914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of BLM with SUMO2,3 (Bos taurus)
REACT:R-XTR-3000348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates SP100 with SUMO2 (Xenopus tropicalis)
REACT:R-MMU-378952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin is a heterodimer (Mus musculus)
GO:0046715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	boron transmembrane transporter activity
GO:0046715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	efflux-type boron transporter
GO:0046715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	active borate transmembrane transporter activity
GO:0046715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	boron uptake transmembrane transporter activity
GO:0046715	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	borate transmembrane transporter activity
GO:0046715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	borate uptake transmembrane transporter activity
GO:0046715	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	efflux-type borate transporter
RHEA:61481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid base + a very long-chain fatty acyl-CoA => an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)
RHEA:53043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:63154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + taurine => an N-fatty acyl-taurine + H2O
RHEA:12900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-1980044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 binds JAG2 (Homo sapiens)
REACT:R-CFA-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Canis familiaris)
REACT:R-HSA-8940998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL36RN, IL1F10 bind IL1RL2 (Homo sapiens)
REACT:R-GGA-975185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Gallus gallus)
REACT:R-GGA-8951490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Gallus gallus)
REACT:R-DME-5693925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT3 transfers L-fucose to Gal1,3GlcNAc (Drosophila melanogaster)
REACT:R-MMU-3000348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates SP100 with SUMO2 (Mus musculus)
REACT:R-CFA-2029272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of PLCG from FCGR (Canis familiaris)
REACT:R-SSC-2465917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Photons induce isomerisation of 11c-retinyl to at-retinyl (Sus scrofa)
RHEA:23467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RHEA:70255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine
REACT:R-CFA-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Canis familiaris)
RHEA:10618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S,4S)-leucocyanidin + H(+) + NADPH => (2R,3S)-catechin + H2O + NADP(+)
REACT:R-RNO-199404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD40L binds CD40 (Rattus norvegicus)
REACT:R-CFA-76576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Canis familiaris)
RHEA:39725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol(out) => a 1,2-diacyl-sn-glycerol(in)
RHEA:44275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:63626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H(+) + hexadecanoyl-[ACP] => hexadecanoyl-AMP + holo-[ACP]
RHEA:60368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urate(out) = urate(in)
REACT:R-DME-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Drosophila melanogaster)
RHEA:70188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose => cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose
REACT:R-HSA-622326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
REACT:R-RNO-9693978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Small molecule inhibitor binds RIPK1, RIPK3 (Rattus norvegicus)
RHEA:44760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-8932633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Canis familiaris)
RHEA:52846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP => 3,4-dihydroxybenzoate + UDP-alpha-D-glucose
REACT:R-HSA-9623280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCK1 gene expression is stimulated by FOXO1:PPARGC1A (Homo sapiens)
GO:0047730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnosine-homocarnosine synthetase activity
GO:0047730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnosine synthetase activity
GO:0047730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine synthase activity
GO:0047730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	homocarnosine-carnosine synthetase activity
GO:0047730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carnosine-anserine synthetase activity
GO:0047730	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-histidine:beta-alanine ligase (AMP-forming)
REACT:R-CFA-165182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of complexed TSC2 by PKB (Canis familiaris)
REACT:R-DDI-3095889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMACHC dealkylates RCbl (Dictyostelium discoideum)
REACT:R-DME-198669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p38MAPK phosphorylates MSK1 (Drosophila melanogaster)
REACT:R-GGA-190829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysosomal degradation of gap junction plaques (Gallus gallus)
REACT:R-RNO-5685994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Long-range resection of DNA DSBs by EXO1 or DNA2 (Rattus norvegicus)
REACT:R-CFA-5218812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates PAK2 (Canis familiaris)
RHEA:31733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O => 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2
REACT:R-SSC-1297275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD9:Izumo Binding (Sus scrofa)
RHEA:40880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
REACT:R-DME-2187309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD2/3:SMAD4 heterotrimer binds SP1 (Drosophila melanogaster)
RHEA:44288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
REACT:R-RNO-8866275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBQLNs bind UIM-containing adaptor proteins (Rattus norvegicus)
REACT:R-HSA-77303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Homo sapiens)
RHEA:23984	skos:prefLabel	"7-dehydrocholesterol reductase"
RHEA:23984	skos:altLabel	"7-dehydrocholesterol dehydrogenase/cholesterol oxidase"
RHEA:23984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + NADP(+) = 7-dehydrocholesterol + H(+) + NADPH
RHEA:23984	skos:altLabel	"Delta(7)-sterol reductase"
RHEA:23984	skos:altLabel	"7-DHC reductase"
RHEA:23984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-dehydrocholesterol reductase"
RHEA:23984	skos:altLabel	"sterol Delta(7)-reductase"
RHEA:17333	skos:altLabel	"lupinic acid synthetase"
RHEA:17333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"zeatin 9-aminocarboxyethyltransferase"
RHEA:17333	skos:altLabel	"lupinate synthetase"
RHEA:17333	skos:altLabel	"beta-(9-cytokinin)alanine synthase"
RHEA:17333	skos:prefLabel	"zeatin 9-aminocarboxyethyltransferase"
RHEA:17333	skos:altLabel	"lupinic acid synthase"
RHEA:17333	skos:altLabel	"O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine)"
RHEA:17333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + zeatin = acetate + H(+) + L-lupinate
RHEA:17333	skos:altLabel	"beta-(9-cytokinin)-alanine synthase"
RHEA:59986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carboxylate + L-glutamine => an N(2)-acyl-L-glutamine + H2O
REACT:R-SSC-5654151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 phosphorylates PLCG1 (Sus scrofa)
REACT:R-CEL-445072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PAK1 with Rac1-GTP (Caenorhabditis elegans)
REACT:R-DDI-8943007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Dictyostelium discoideum)
REACT:R-MMU-193393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Mus musculus)
RHEA:41042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA
REACT:R-SSC-5653780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP43 binds ISG:K164,ISG:K168-PCNA (Sus scrofa)
REACT:R-XTR-5692480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A2 transports cations from cytosol to lysosomal lumen (Xenopus tropicalis)
GO:0033797	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	selenite:reduced acceptor oxidoreductase activity
GO:0033797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenate reductase activity
RHEA:57633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-6794346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind NLGNs (Sus scrofa)
RHEA:69487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecan-1-ol + O2 <=> dodecanal + H2O2
REACT:R-MMU-196753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPPCS ligates PPanK with Cys (Mus musculus)
REACT:R-BTA-2025724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Bos taurus)
REACT:R-DME-927889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
RHEA:19880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
RHEA:22840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamine + H2O = D-glutamate + NH4(+)
RHEA:22840	skos:prefLabel	"D-glutaminase"
RHEA:22840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-glutaminase"
RHEA:64406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine(in) + H(+)(in) => carnosine(out) + H(+)(out)
REACT:R-DME-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Drosophila melanogaster)
REACT:R-DME-350362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROK phosphorylates MBS (Drosophila melanogaster)
GO:0030170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyridoxal phosphate binding
REACT:R-DRE-193491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Danio rerio)
RHEA:20692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorogenate + H2O <=> (E)-caffeate + H(+) + L-quinate
REACT:R-XTR-3788724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Xenopus tropicalis)
REACT:R-HSA-5690996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)
REACT:R-HSA-68946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)
RHEA:34418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-bornane-2,5-dione + FMNH2 + O2 <=> (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O
GO:0001602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pancreatic polypeptide receptor activity
REACT:R-BTA-5082405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of HSF1 at Ser326 induces transactivation (Bos taurus)
REACT:R-SSC-8852136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the nucleus (Sus scrofa)
REACT:R-RNO-109278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Rattus norvegicus)
REACT:R-HSA-3781011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Homo sapiens)
GO:0048156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tau protein binding
RHEA:37114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-tetracosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine
REACT:R-HSA-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acyl-activating enzyme activity
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-(+)-3-hydroxybutyryl CoA ligase activity
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyryl-CoA synthetase activity
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acid activating enzyme
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	medium chain acyl-CoA synthetase activity
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	short-chain acyl-CoA synthetase activity
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acyl coenzyme A synthetase activity
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty acid thiokinase (medium chain) activity
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butyrate-CoA ligase activity
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butanoate:CoA ligase (AMP-forming)
GO:0047760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	butyryl-coenzyme A synthetase activity
RHEA:31606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-ureidoacrylate + H2O <=> (Z)-3-aminoacrylate + carbamate + H(+)
GO:0033911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mycodextranase activity
GO:0033911	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity
RHEA:10832	skos:altLabel	"glycoprotein phospholipase D"
RHEA:10832	skos:altLabel	"phosphatidylinositol-glycan-specific phospholipase D"
RHEA:10832	skos:altLabel	"phosphatidylinositol-specific phospholipase D"
RHEA:10832	skos:altLabel	"GPI-PLD"
RHEA:10832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycosylphosphatidylinositol phospholipase D"
RHEA:10832	skos:altLabel	"phosphatidylinositol phospholipase D"
RHEA:10832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)
RHEA:10832	skos:prefLabel	"glycosylphosphatidylinositol phospholipase D"
REACT:R-XTR-389889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Xenopus tropicalis)
RHEA:22550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2
RHEA:52315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + thromboxane B2 <=> 11-dehydro-thromboxane B2 + H(+) + NADH
REACT:R-HSA-6809944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
RHEA:12812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 catechol + 3 O2 <=> 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O
RHEA:49187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H(+) + H2O <=> 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol
RHEA:69450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-cadinol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
REACT:R-BTA-199935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates CREB (Bos taurus)
REACT:R-HSA-166795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Classical C3 convertase (C4b:C2a complex) (Homo sapiens)
RHEA:64682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + ethyl benzoate => benzoyl-CoA + ethanol
RHEA:42582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + L-seryl-tRNA(Sec) => ATP + L-serine + tRNA(Sec)
RHEA:47134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinoate + 2 H(+) + NADH => 11-cis-retinal + H2O + NAD(+)
EC:3.2.1.147	skos:prefLabel	"thioglucosidase"
EC:3.2.1.147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thioglucosidase"
EC:3.2.1.147	skos:altLabel	"sinigrase"
EC:3.2.1.147	skos:altLabel	"myrosinase"
EC:3.2.1.147	skos:altLabel	"sinigrinase"
REACT:R-HSA-2464822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH12 reduces atRAL to atROL (Homo sapiens)
REACT:R-DDI-435171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
RHEA:67880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)
RHEA:52716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alcohol-forming fatty acyl-CoA reductase"
RHEA:52716	skos:prefLabel	"alcohol-forming fatty acyl-CoA reductase"
RHEA:52716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)
GO:0008657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA gyrase inhibitor activity
GO:0008657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
GO:0017124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH3 domain binding
REACT:R-HSA-171288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of the viral Env gp160 precursor polyprotein (Homo sapiens)
RHEA:31551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	presqualene diphosphate = 15-cis-4,4'-diapophytoene + diphosphate
REACT:R-DDI-9638078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXB cleaves the terminal GalNAc from keratan sulfate (Dictyostelium discoideum)
RHEA:55638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate => ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O
REACT:R-HSA-212222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 recruits DNA methyltransferases (Homo sapiens)
REACT:R-DME-1602466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of MT-MMPs by FURIN (Drosophila melanogaster)
REACT:R-XTR-195318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Xenopus tropicalis)
RHEA:53379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(16) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(16) in tRNA
REACT:R-CFA-392053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS binds Grb2 bound to pFAK:NCAM1 (Canis familiaris)
RHEA:46330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + NH4(+) => L-threo-3-phenylserine
REACT:R-DRE-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Danio rerio)
REACT:R-MMU-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Mus musculus)
REACT:R-SSC-428918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of the TP:G13 complex (Sus scrofa)
REACT:R-HSA-162742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)
REACT:R-XTR-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Xenopus tropicalis)
RHEA:24293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-glutamate => CoA + H(+) + N-acetyl-L-glutamate
RHEA:64572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyl diphosphate + neryl diphosphate = (2Z,6Z)-farnesyl diphosphate + diphosphate
REACT:R-XTR-2162227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUSB tetramer hydrolyses (HA)2 (Xenopus tropicalis)
RHEA:17641	skos:prefLabel	"arginine decarboxylase"
RHEA:17641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-arginine = agmatine + CO2
RHEA:17641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginine decarboxylase"
RHEA:17641	skos:altLabel	"L-arginine carboxy-lyase"
GO:0030784	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity
GO:0030784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity
REACT:R-HSA-2130151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of DAP12 (Homo sapiens)
REACT:R-PFA-70613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GOT2 transaminates oxaloacetate and glutamate (Plasmodium falciparum)
GO:0004835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TTL activity
GO:0004835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulinyl-tyrosine ligase activity
GO:0004835	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-tubulin:L-tyrosine ligase (ADP-forming)
GO:0004835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tubulin-tyrosine ligase activity
REACT:R-HSA-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Homo sapiens)
REACT:R-CFA-5684071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF4 ubiquitinates MDC1 (Canis familiaris)
REACT:R-SSC-173709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C7 binds C5b:C6 (Sus scrofa)
REACT:R-XTR-193052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pregn-5-ene-3,20-dione isomerizes to progesterone (Xenopus tropicalis)
RHEA:58758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH
REACT:R-HSA-165026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Homo sapiens)
REACT:R-HSA-1912416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 gene transcription (Homo sapiens)
REACT:R-BTA-6813749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH1A1 oxidises GA to DGA (Bos taurus)
REACT:R-CFA-171141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Canis familiaris)
REACT:R-XTR-8938770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Xenopus tropicalis)
RHEA:40598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanedioyl-CoA + H2O <=> CoA + dodecanedioate + H(+)
REACT:R-RNO-9617595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGTA binds mislocalized membrane protein (Rattus norvegicus)
GO:0047943	skos:prefLabel	"glutamate--methylamine ligase"
GO:0047943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamate + methylamine = ADP + H(+) + N(5)-methyl-L-glutamine + phosphate
GO:0047943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate--methylamine ligase"
GO:0047943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate-methylamine ligase activity
GO:0047943	skos:altLabel	"gamma-glutamylmethylamide synthetase"
GO:0047943	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-glutamate:methylamine ligase (ADP-forming)
GO:0047943	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gamma-glutamylmethylamide synthetase activity
RHEA:15490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + H2O + 2 O2 => 9-riburonosyladenine + H(+) + 2 H2O2
RHEA:35998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-XTR-977348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHGDH tetramer dehydrogenates 3PG (Xenopus tropicalis)
REACT:R-HSA-9614669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASLG gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)
REACT:R-HSA-158832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The acetyl group from acetyl-CoA is transferred to the NAT2 (Homo sapiens)
REACT:R-SSC-349638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassembly of SR-BI-bound spherical HDL (Sus scrofa)
REACT:R-MMU-8854302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D7 binds the TSC1-TSC2 complex (Mus musculus)
REACT:R-RNO-163296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of TFAM:mt promoter complex with POLRMT:TFB2M (Rattus norvegicus)
RHEA:69723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetyl-AMP + CoA = (indol-3-yl)acetyl-CoA + AMP + H(+)
RHEA:64212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-isoleucine + H2O = a fatty acid + L-isoleucine
RHEA:37785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine
RHEA:19370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine
REACT:R-BTA-3222593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6B demethylates H3K27me3 on p16INK4A promoter (Bos taurus)
RHEA:66072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine
REACT:R-MMU-8950210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 dissociates from Interleukin-27 receptor (Mus musculus)
RHEA:36880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O
RHEA:71099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)
REACT:R-BTA-3769383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBY1 binds beta-catenin (Bos taurus)
REACT:R-CFA-164832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATPase synthesizes ATP (Canis familiaris)
RHEA:68433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lutein + O2 => (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal
RHEA:22455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[phosphate](n+1) + n H2O <=> n H(+) + (n+1) phosphate
REACT:R-RNO-9008270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds ESR1:estrogen:TGFA gene (Rattus norvegicus)
RHEA:41445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 => glycine + 2 H(+) + phosphate
REACT:R-XTR-9018806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GAPs stimulate RAC3 GTPase activity (Xenopus tropicalis)
REACT:R-GGA-433804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKK epsilon is recruited to the Viral dsRNA:TLR3:TICAM1 complex  (Gallus gallus)
REACT:R-BTA-8983298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)
REACT:R-CFA-8941613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
REACT:R-DRE-389348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rac1 by pVav1 (Danio rerio)
REACT:R-SSC-5665809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Sus scrofa)
RHEA:19768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol <=> 3-hydroxypropanal + H2O
RHEA:51812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)
REACT:R-RNO-1605768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) (Rattus norvegicus)
REACT:R-DDI-482812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Dictyostelium discoideum)
REACT:R-SSC-109699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
REACT:R-BTA-398185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG binds plexin B1 (Bos taurus)
GO:0043804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + imidazol-4-one = N-formimidoylglycine
GO:0043804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	imidazolone hydrolase activity
RHEA:39716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O
REACT:R-RNO-879411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Rattus norvegicus)
RHEA:14621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene = lanosterol
RHEA:14621	skos:altLabel	"2,3-epoxysqualene--lanosterol cyclase"
RHEA:14621	skos:prefLabel	"lanosterol synthase"
RHEA:14621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lanosterol synthase"
RHEA:14621	skos:altLabel	"oxidosqualene--lanosterol cyclase"
RHEA:14621	skos:altLabel	"squalene-2,3-oxide-lanosterol cyclase"
GO:0102328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoacid decarboxylase activity
REACT:R-CFA-1606807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside (Canis familiaris)
RHEA:45574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alginate](n) => [(1->4)-beta-D-mannuronosyl](n)
REACT:R-BTA-8865265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C homodimer binds MYC and KDM5B (Bos taurus)
RHEA:51346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenine triphosphate adenylyltransferase activity
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dinucleoside oligophosphate alphabeta-phosphorylase activity
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP:ATP adenylyltransferase activity
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AP-4-A phosphorylase activity
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosinetetraphosphate alphabeta-phosphorylase activity
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosinetetraphosphate alpha-beta-phosphorylase activity
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP adenylyltransferase activity
GO:0003877	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)
REACT:R-CEL-9712274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Caenorhabditis elegans)
REACT:R-DDI-2162002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Dictyostelium discoideum)
REACT:R-RNO-873919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of JAK2 (Rattus norvegicus)
REACT:R-DDI-1369052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid influx (Dictyostelium discoideum)
REACT:R-SSC-5668414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Sus scrofa)
REACT:R-RNO-1296039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with small conductance (Rattus norvegicus)
REACT:R-SSC-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Sus scrofa)
RHEA:55483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
GO:1901478	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	aminotriazole transporter activity
GO:1901478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminotriazole transmembrane transporter activity
RHEA:61668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + salicylate = 2-hydroxybenzoyl-CoA + AMP + diphosphate
RHEA:61668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"salicylate--CoA ligase"
RHEA:61668	skos:prefLabel	"salicylate--CoA ligase"
REACT:R-DME-8866269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB bind GPCRs (Drosophila melanogaster)
REACT:R-SSC-2230938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hemoglobin:Haptoglobin:CD163 is endocytosed (Sus scrofa)
RHEA:46018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + progesterone => (20R)-20-hydroxypregn-4-en-3-one + NAD(+)
EC:2.5.1.-	skos:prefLabel	"Transferring alkyl or aryl groups, other than methyl groups"
EC:2.5.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Transferring alkyl or aryl groups, other than methyl groups"
RHEA:67181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + L-glutamyl-[protein] => ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate
REACT:R-CEL-8985594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYO9B inactivates RHOA (Caenorhabditis elegans)
REACT:R-CEL-113430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Caenorhabditis elegans)
REACT:R-CFA-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Canis familiaris)
REACT:R-SSC-199935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSK1 activates CREB (Sus scrofa)
RHEA:46365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:29065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + CO2 => a menaquinone + formate + H(+)
GO:0016652	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, acting on NAD or NADPH, NAD or NADP as acceptor
GO:0016652	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0016652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
GO:0016652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor
REACT:R-RNO-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Rattus norvegicus)
REACT:R-BTA-2219524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP2 (Bos taurus)
RHEA:35061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloramphenicol(out) + H(+)(in) => chloramphenicol(in) + H(+)(out)
RHEA:57861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-6-hydroxyferuloyl-CoA => CoA + scopoletin
RHEA:35373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate => 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A
RHEA:59518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate => acetylsalicylate + L-lysyl-[protein]
REACT:R-GGA-174427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Gallus gallus)
GO:0140318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein carrier activity
GO:0140318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein transporter activity
GO:0140318	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein transport chaperone
RHEA:33685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoeicosasphinganine + CO2 + CoA => H(+) + L-serine + octadecanoyl-CoA
RHEA:56375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)
REACT:R-HSA-3229102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
REACT:R-XTR-198440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Xenopus tropicalis)
RHEA:61067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP
RHEA:16086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
RHEA:72495	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate(in) + prostaglandin E2(out) = glutarate(out) + prostaglandin E2(in)
REACT:R-HSA-9035143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H2,3 binds the APOC4 gene (Homo sapiens)
REACT:R-DRE-428664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Danio rerio)
RHEA:71524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenine(out) => adenine(in)
REACT:R-DRE-8863472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAB2 binds LRP2 (Danio rerio)
REACT:R-CEL-1227671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of HDAC1 by p107 (RBL1) (Caenorhabditis elegans)
RHEA:27563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + 7 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 7 diphosphate
RHEA:27563	skos:altLabel	"solanesyl-diphosphate synthase"
RHEA:27563	skos:prefLabel	"all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]"
RHEA:27563	skos:altLabel	"nonaprenyl diphosphate synthase"
RHEA:27563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]"
RHEA:10983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine <=> D-serine
RHEA:41205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
REACT:R-DRE-8952626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Danio rerio)
RHEA:56745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[protein] + O2 => (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate
GO:0004640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoribosylanthranilate isomerase activity
GO:0004640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(5'-phosphoribosyl)anthranilate isomerase activity
GO:0004640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity
GO:0004640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)
GO:0004640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PRAI activity
GO:0004640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity
GO:0004640	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PRA isomerase activity
REACT:R-SSC-5626953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-α:TNFR1 binds DENN/MADD (Sus scrofa)
REACT:R-BTA-444208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLNR (GPR38) is a receptor for motilin (Bos taurus)
REACT:R-RNO-3134953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 or DHX9 binds MyD88 (Rattus norvegicus)
REACT:R-BTA-202443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of CARMA1 (Bos taurus)
REACT:R-PFA-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Plasmodium falciparum)
REACT:R-CFA-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Canis familiaris)
REACT:R-DME-1675883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Drosophila melanogaster)
REACT:R-DME-964958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xPDXK:2xZn2+ phosphorylates PXA (Drosophila melanogaster)
REACT:R-BTA-389759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP-1 or SHP-2 with phospho PD-1 (Bos taurus)
REACT:R-XTR-9714415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 binds TCAs and SSRIs (Xenopus tropicalis)
REACT:R-BTA-9708859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)
RHEA:17833	skos:prefLabel	"3-hydroxyanthranilate 4-C-methyltransferase"
RHEA:17833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-hydroxyanthranilate 4-C-methyltransferase"
RHEA:17833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-9029580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Mus musculus)
REACT:R-DRE-2028583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of YAP by LATS2 (Danio rerio)
RHEA:47603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM4 (d18:1(4E)) + H(+)
RHEA:36283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,7-dimethylxanthine + H(+) + NADPH + O2 = 7-methylxanthine + formaldehyde + H2O + NADP(+)
RHEA:66235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IC-asc-C7-CoA + O2 <=> H2O2 + IC-asc-DeltaC7-CoA
RHEA:45422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine
RHEA:47913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O
REACT:R-GGA-420243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHRH receptor binds GHRH (Gallus gallus)
RHEA:29724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate(in) => glyoxylate(out)
RHEA:42623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-2-methylureidoacrylate + H(+) + H2O <=> (Z)-2-methylaminoacrylate + CO2 + NH4(+)
GO:0032931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H3-K56 specific)
GO:0032931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K56 acetyltransferase activity
GO:0032931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K56 acetyltransferase activity
GO:0032931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H3-K56 specific)
GO:0032931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H3-K56 specific)
REACT:R-DME-5689861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of XPA and release of CAK  (Drosophila melanogaster)
RHEA:61427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-cis-nepetalactol + NAD(+) <=> cis-cis-nepetalactone + H(+) + NADH
RHEA:48318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ganglioside GD1alpha + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b
REACT:R-MMU-5218845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Mus musculus)
RHEA:65003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[ACP] + octanoyl-AMP <=> AMP + H(+) + octanoyl-[ACP]
REACT:R-SSC-8852324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds PLK1 (Sus scrofa)
REACT:R-XTR-977615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates MCP/CR1-bound C4b/C3b (Xenopus tropicalis)
REACT:R-DRE-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Danio rerio)
RHEA:31537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate => 2-oxoglutarate + L-arginine + O2
REACT:R-MMU-9036987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Mus musculus)
REACT:R-CFA-5690066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)
RHEA:10017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-sinapoylcholine => (E)-sinapate + choline + H(+)
RHEA:38513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O
RHEA:45578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-methylsuccinyl-CoA => (2R)-ethylmalonyl-CoA
RHEA:51328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 = 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate
REACT:R-MMU-9632038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)
REACT:R-XTR-9615348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR2 (Xenopus tropicalis)
RHEA:38018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocotrienol <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol
GO:0018577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catechol 2,3-oxygenase
GO:0018577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	metapyrocatechase activity
GO:0018577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catechol:oxygen 2,3-oxidoreductase (decyclizing)
GO:0018577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2,3-pyrocatechase activity
GO:0018577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol 2,3-dioxygenase activity
GO:0018577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cato2ase activity
GO:0018577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrocatechol 2,3-dioxygenase
GO:0018577	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	catechol oxygenase
REACT:R-DRE-5694410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TMED2:TMED10 tetramer binds GPI anchored proteins (Danio rerio)
REACT:R-SSC-5654510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 binds SPRED1/2 (Sus scrofa)
REACT:R-BTA-4341016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Bos taurus)
REACT:R-HSA-2972968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALL4 binds the SALL4 promoter (Homo sapiens)
REACT:R-CFA-6786293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Canis familiaris)
REACT:R-DME-2684507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecans 1, 2, 4, (3) bind FGF2 (Drosophila melanogaster)
REACT:R-XTR-997263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMJD1C demethylates H3K9 mono- and di-methylation (Xenopus tropicalis)
REACT:R-MMU-1504213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Mus musculus)
REACT:R-MMU-140761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequestered tissue factor -> tissue factor (Mus musculus)
REACT:R-XTR-5654584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS bind to PPTN11 (Xenopus tropicalis)
REACT:R-HSA-70577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Homo sapiens)
RHEA:39070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanedioyl-CoA + CoA <=> acetyl-CoA + hexanedioyl-CoA
REACT:R-GGA-9626880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Gallus gallus)
REACT:R-DRE-202248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma1 (Danio rerio)
RHEA:38684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + sphing-4-enine(in) => ADP + H(+) + phosphate + sphing-4-enine(out)
REACT:R-SSC-75848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACLY tetramer transforms CIT to Ac-CoA (Sus scrofa)
REACT:R-MMU-2090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLB1 hydrolyses linker chain(2) (Mus musculus)
RHEA:23287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopentenyl diphosphate <=> dimethylallyl diphosphate
RHEA:45732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-tyrosine isonitrile synthase"
RHEA:45732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + L-tyrosine = (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate
RHEA:45732	skos:prefLabel	"L-tyrosine isonitrile synthase"
REACT:R-SSC-8869607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NAR to yield NAMN (Sus scrofa)
REACT:R-SSC-3222072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAXX binds Ub-MDM2 and USP7 (Sus scrofa)
REACT:R-RNO-1112538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STAT1, STAT3 form dimers (Rattus norvegicus)
RHEA:56255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP
RHEA:64000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-hydroxysphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine
REACT:R-HSA-5621425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective AVP mutants do not bind AVPR1A,B (Homo sapiens)
RHEA:56064	skos:altLabel	"beta-glucoside alpha-1,3-xylosyltransferase"
RHEA:56064	skos:altLabel	"UDP-alpha-D-xylose:beta-D-glucoside 3-alpha-D-xylosyltransferase"
RHEA:56064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:56064	skos:prefLabel	"UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase"
RHEA:56064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase"
REACT:R-HSA-1564142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)
REACT:R-RNO-8983379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3:p-STAT5 translocates to the nucleus (Rattus norvegicus)
REACT:R-DDI-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Dictyostelium discoideum)
REACT:R-DRE-5626938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin binds SOX proteins (Danio rerio)
REACT:R-XTR-5626681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of transition zone proteins (Xenopus tropicalis)
REACT:R-DME-2161187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)
REACT:R-DRE-8862733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR2, CCR3 bind CCL13 (Danio rerio)
REACT:R-CFA-163664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binds to gamma subunit of AMP kinase heterotrimer (Canis familiaris)
GO:0043829	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TAD1
GO:0043829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA(Ala)-A37 deaminase activity
GO:0043829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-specific adenosine deaminase 1
GO:0043829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-specific adenosine-37 deaminase activity
RHEA:64791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + ATP + CoA <=> (E)-cinnamoyl-CoA + AMP + diphosphate
REACT:R-BTA-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Bos taurus)
REACT:R-DME-9638127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G6P to G1P (Drosophila melanogaster)
RHEA:51640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 = (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate
RHEA:40476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tributanoylglycerol + H2O => butanoate + dibutanoylglycerol + H(+)
RHEA:72602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-aspartyl-L-glutamate(out) <=> N-acetyl-L-aspartyl-L-glutamate(in)
EC:6.5.1.3	skos:prefLabel	"RNA ligase (ATP)"
EC:6.5.1.3	skos:altLabel	"ribonucleic ligase"
EC:6.5.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"RNA ligase (ATP)"
EC:6.5.1.3	skos:altLabel	"polyribonucleotide synthase (ATP)"
RHEA:22521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinal + H2O + O2 => all-trans-retinoate + H(+) + H2O2
RHEA:27883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-CMP + H2O => 3'-CMP + H(+)
REACT:R-SSC-5624127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome target cargo to the primary cilium (Sus scrofa)
REACT:R-SSC-8852129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)
REACT:R-DDI-5676229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WIPIs bind PI3P (Dictyostelium discoideum)
REACT:R-RNO-173512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Rattus norvegicus)
RHEA:27470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N,N'-diacetylchitobiose => acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine
REACT:R-DME-3928601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 and PIP2 bind WASL, activating it (Drosophila melanogaster)
RHEA:38285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	itaconyl-CoA + succinate => itaconate + succinyl-CoA
RHEA:35772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-5-amino-3-dehydroshikimate => 3-amino-5-hydroxybenzoate + H(+) + H2O
REACT:R-RNO-70573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	argininosuccinate <=> fumarate + arginine (Rattus norvegicus)
REACT:R-MMU-5358579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase delta polymerizes DNA across single stranded gap (Mus musculus)
RHEA:64890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + tetradecanoyl-[ACP] => ATP + holo-[ACP] + tetradecanoate
RHEA:23735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-diphosphomevalonate + ATP <=> ADP + CO2 + isopentenyl diphosphate + phosphate
REACT:R-XTR-994137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Xenopus tropicalis)
GO:0016708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor
GO:0016708	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor
RHEA:58794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + Fe(III)-petrobactin(in) + H(+) + phosphate => ATP + Fe(III)-petrobactin(out) + H2O
GO:0005254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride channel activity
REACT:R-DRE-174446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap from the C-strand (Danio rerio)
REACT:R-DDI-742373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Dictyostelium discoideum)
REACT:R-XTR-1638821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A-B56 dephosphorylates centromeric cohesin (Xenopus tropicalis)
RHEA:25099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + UDP => ADP + UTP
RHEA:25146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine + H2O <=> 3-hydroxyanthranilate + H(+) + L-alanine
REACT:R-RNO-5623521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3IP stimulates nucleotide exchange on RAB8A (Rattus norvegicus)
RHEA:22693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + H(+) + NADH + O2 => 2,5-dihydroxybenzoate + H2O + NAD(+)
REACT:R-DME-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Drosophila melanogaster)
RHEA:35478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'S)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + H(+) + NADH
RHEA:20090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-leucine => CoA + H(+) + N-acetyl-L-leucine
REACT:R-SSC-173545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Sus scrofa)
RHEA:57693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]
RHEA:36582	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-fucose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH
REACT:R-MMU-2022851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfer GlcNAc to the heparan chain (Mus musculus)
REACT:R-MMU-6797568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRXNs bind CASK:Protein 4.1 (Mus musculus)
REACT:R-CFA-202534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of NEMO by TRAF6 (Canis familiaris)
REACT:R-MMU-168848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tBID binds to inactive BAK protein (Mus musculus)
RHEA:13350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	jasmonate + S-adenosyl-L-methionine => methyl (-)-jasmonate + S-adenosyl-L-homocysteine
REACT:R-HSA-9718394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNRHR binds GNRHR peptide antagonists (Homo sapiens)
REACT:R-BTA-5654596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
RHEA:67748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate
RHEA:22956	skos:altLabel	"alkylacylglycerophosphoethanolamine desaturase"
RHEA:22956	skos:altLabel	"2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase"
RHEA:22956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:22956	skos:prefLabel	"plasmanylethanolamine desaturase"
RHEA:22956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plasmanylethanolamine desaturase"
RHEA:71721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in) => H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out)
RHEA:12450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + beta-alanine => (R)-pantothenate + H2O
REACT:R-SSC-2022412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)
REACT:R-RNO-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Rattus norvegicus)
RHEA:35742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone
GO:0052381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl-diphosphate:tRNA dimethylallyltransferase activity
GO:0052381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA dimethylallyltransferase activity
GO:0052381	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA isopentenyltransferase activity
GO:0052381	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	tRNA prenyltransferase activity
REACT:R-XTR-378975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Follitropin is a heterodimer (Xenopus tropicalis)
RHEA:51199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + Na(+)(out) + serotonin(out) <=> chloride(in) + Na(+)(in) + serotonin(in)
RHEA:19723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA
REACT:R-DRE-3900177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DDX5 with SUMO1 (Danio rerio)
REACT:R-DRE-75146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Danio rerio)
RHEA:72338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate <=> 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
RHEA:52686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + pyridoxal => NAD(+) + pyridoxine
RHEA:23238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-glutamyl-[protein] + methanol => [protein]-L-glutamate 5-O-methyl ester + H2O
REACT:R-DRE-194311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Danio rerio)
RHEA:30333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
RHEA:62671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyherqueinone + H(+) + NADPH + O2 <=> H2O + herqueinone + NADP(+)
REACT:R-RNO-114284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of Cytochrome c from mitochondria (Rattus norvegicus)
REACT:R-SSC-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Sus scrofa)
RHEA:62533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigitoxin + 2 Fe(III)-[cytochrome c]
RHEA:57020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apulose + ATP = ADP + apulose 4-phosphate + H(+)
RHEA:57020	skos:prefLabel	"apulose kinase"
RHEA:57020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"apulose kinase"
REACT:R-DME-8952058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1 binds RUNX3 and displaces EP300 (Drosophila melanogaster)
REACT:R-SPO-9709179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4 binds DPP4 inhibitors (Schizosaccharomyces pombe)
RHEA:61626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminopentanal + L-glutamate => 2-oxoglutarate + cadaverine
RHEA:55491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:11920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O
RHEA:11920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4a-hydroxytetrahydrobiopterin dehydratase"
RHEA:11920	skos:altLabel	"pterin-4alpha-carbinolamine dehydratase"
RHEA:11920	skos:prefLabel	"4a-hydroxytetrahydrobiopterin dehydratase"
RHEA:11920	skos:altLabel	"4alpha-hydroxy-tetrahydropterin dehydratase"
RHEA:11920	skos:altLabel	"tetrahydrobiopterin dehydratase"
GO:0033845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylfurfural reductase (NADPH) activity
REACT:R-CEL-182986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)
RHEA:45487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + pyruvate <=> acetaldehyde + CO2
REACT:R-DDI-202164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PDK1 to Plasma membrane (Dictyostelium discoideum)
REACT:R-SPO-69173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments (Schizosaccharomyces pombe)
RHEA:45489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]
REACT:R-DME-3928647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Drosophila melanogaster)
REACT:R-RNO-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Rattus norvegicus)
REACT:R-CFA-6799431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds HIPK1 (Canis familiaris)
REACT:R-BTA-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Bos taurus)
RHEA:40451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)
RHEA:30343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + succinate = FADH2 + fumarate
REACT:R-HSA-71588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Homo sapiens)
REACT:R-SPO-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Schizosaccharomyces pombe)
REACT:R-CFA-8954468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Canis familiaris)
REACT:R-HSA-5324617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90:FKBP4:PTGES3 binds HSF1 trimer (Homo sapiens)
RHEA:40513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + H(+) + NADH => (2S)-3-sulfopropanediol + NAD(+)
RHEA:37595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-SSC-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)
REACT:R-BTA-8870461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA and RABGGTB bind (Bos taurus)
RHEA:16471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-benzylsuccinyl-CoA + succinate => (R)-2-benzylsuccinate + succinyl-CoA
REACT:R-XTR-375770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Xenopus tropicalis)
RHEA:61994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine
RHEA:14632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N-acetyl-L-glutamate <=> ADP + N-acetyl-L-glutamyl 5-phosphate
REACT:R-DRE-8940100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates VCPIP1 (Danio rerio)
REACT:R-SSC-5626223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Sus scrofa)
REACT:R-MMU-442314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV3 is a GEF for Rho/Rac family kinases (Mus musculus)
REACT:R-SSC-9013109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC GEFs activate RHOC (Sus scrofa)
REACT:R-BTA-2128994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Bos taurus)
REACT:R-RNO-450463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Rattus norvegicus)
REACT:R-HSA-1236941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Internalization of receptor bound antigen into clathrin coted vesicles (Homo sapiens)
RHEA:10227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + pyridoxal <=> ADP + H(+) + pyridoxal 5'-phosphate
RHEA:58209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + dihydroalstonine => AH2 + alstonine
REACT:R-SPO-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Schizosaccharomyces pombe)
REACT:R-RNO-5689000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Rattus norvegicus)
RHEA:14296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + NAD(+) <=> D-glucono-1,5-lactone + H(+) + NADH
RHEA:48820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
RHEA:61681	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-cysteine => AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]
REACT:R-BTA-210439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate uptake by astrocytes (Bos taurus)
REACT:R-CFA-201422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Canis familiaris)
REACT:R-GGA-4341025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR3C1 (GR) with SUMO1 (Gallus gallus)
REACT:R-RNO-2995389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 binds VRK1,(VRK2) (Rattus norvegicus)
REACT:R-RNO-1112514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK activation (Rattus norvegicus)
RHEA:17464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sedoheptulose 1,7-bisphosphate + H2O <=> D-sedoheptulose 7-phosphate + phosphate
RHEA:59918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoate + 2 H(+) + NADPH => (2E)-octenal + H2O + NADP(+)
REACT:R-HSA-451757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterodimerization of nephrin and KIRREL2, KIRREL3 (Homo sapiens)
REACT:R-CEL-9702849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CALCR binds gepants (Caenorhabditis elegans)
REACT:R-RNO-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Rattus norvegicus)
REACT:R-MMU-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Mus musculus)
REACT:R-HSA-2022381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
RHEA:69531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + H2O + 2 L-glutamine <=> 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)
REACT:R-DDI-6814254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA6 hydrolyzes LysoPtdCho (Dictyostelium discoideum)
REACT:R-DDI-2090037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA hydrolyses Heparan sulfate chain(6) (Dictyostelium discoideum)
REACT:R-BTA-4086083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of ING2 with SUMO1 (Bos taurus)
REACT:R-CFA-111215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Canis familiaris)
REACT:R-DRE-211164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO1A (Danio rerio)
REACT:R-HSA-9673760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)
RHEA:40440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-sulfo-beta-D-quinovose => 6-deoxy-6-sulfo-D-fructose
RHEA:61792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tryptophan = diphosphate + L-tryptophyl-5'-AMP
RHEA:53617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O => (+)-isoafricanol + diphosphate
RHEA:47613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP
REACT:R-CEL-427570	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Group 3 - Selective Cl- transport (Caenorhabditis elegans)
RHEA:13080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl phosphate + D-hexose <=> a carboxylate + D-hexose phosphate + H(+)
RHEA:17725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O
RHEA:17725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-methylcitrate dehydratase"
RHEA:17725	skos:altLabel	"2-methylcitrate hydro-lyase"
RHEA:17725	skos:prefLabel	"2-methylcitrate dehydratase"
RHEA:17725	skos:altLabel	"2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase"
GO:0086080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein binding involved in heterotypic cell-cell adhesion
REACT:R-HSA-5692237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH5 oxidises S-HMGSH to S-FGSH (Homo sapiens)
RHEA:42191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH
REACT:R-DRE-9756169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)
EC:2.8.3.22	skos:prefLabel	"succinyl-CoA--L-malate CoA-transferase"
EC:2.8.3.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinyl-CoA--L-malate CoA-transferase"
REACT:R-CFA-400097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-beta:G-gamma inhibits Adenylate cyclase (Canis familiaris)
REACT:R-DRE-9793680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPTN binds polyUb-RIPK1 within the TNFR1 complex (Danio rerio)
REACT:R-MMU-4755494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Mus musculus)
REACT:R-CFA-8855825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HTRA1 hydrolyzes ACAN (Aggrecan) (Canis familiaris)
REACT:R-MMU-9708261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE4A hydrolyses cAMP to AMP (Mus musculus)
REACT:R-DME-6797616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK:CDK12 binds RNA Pol II at DNA repair genes (Drosophila melanogaster)
RHEA:64388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 A + sn-3-O-phytanylglycerol 1-phosphate = 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
GO:0016462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT13 hydrolyses AP6A to AP4 and ADP (Homo sapiens)
GO:0016462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrophosphatase activity
GO:0030911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetratricopeptide repeat domain binding
GO:0030911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPR domain binding
REACT:R-BTA-351963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A18 transports Gly from extracellular region to cytosol (Bos taurus)
REACT:R-CFA-507871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport glycerol out of cells (Canis familiaris)
REACT:R-RNO-9037761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Rattus norvegicus)
REACT:R-MMU-9020274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Mus musculus)
REACT:R-HSA-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)
REACT:R-MMU-5687101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T182 MAPKAPK5 phosphorylates FOXO3 (Mus musculus)
RHEA:48204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-DRE-5625797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Danio rerio)
RHEA:45846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctanoyl-CoA + NADP(+)
REACT:R-DME-6785636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated ERBB2 heterodimers bind MEMO1 (Drosophila melanogaster)
REACT:R-BTA-6810235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Bos taurus)
REACT:R-CFA-391905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxoeicosanoid receptor can bind oxoeicosanoid (Canis familiaris)
REACT:R-HSA-9035988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective HLCS does not biotinylate PC:Mn2+ (Homo sapiens)
RHEA:61988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:51998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:63206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + holo-[ACP] + octadecanoate => H2O + octadecanoyl-[ACP]
RHEA:72558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + propanoate(in) <=> estrone 3-sulfate(in) + propanoate(out)
RHEA:37897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-deglucoprotodioscin + D-glucose => H2O + protodioscin
RHEA:22871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-chloro-L-alanine + thioglycolate <=> chloride + H(+) + S-carboxymethyl-L-cysteine
RHEA:62024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	campesteryl 3-beta-D-glucoside + H2O = campesterol + D-glucose
REACT:R-HSA-5687097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S857 NCOA3 binds ETV4 (Homo sapiens)
REACT:R-BTA-2395320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 binds integrins (Bos taurus)
RHEA:39124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA
REACT:R-RNO-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Rattus norvegicus)
REACT:R-DDI-5690319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL1, UCHL3 cleave ubiquitin adducts (Dictyostelium discoideum)
RHEA:50900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O = (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate
REACT:R-CEL-5637686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)
REACT:R-HSA-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Homo sapiens)
REACT:R-HSA-5362459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)
REACT:R-CEL-1234161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIF-alpha translocates from cytosol to nucleus (Caenorhabditis elegans)
REACT:R-CEL-1676109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)
GO:1901682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur molecular entity transmembrane transporter activity
GO:1901682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfur compound transmembrane transporter activity
RHEA:68652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-homocysteine = H(+) + hydrogen sulfide + L-homolanthionine
REACT:R-DRE-870538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Danio rerio)
RHEA:37850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-dihydrodaunorubicin + H(+) + NADPH + O2 <=> daunorubicin + 2 H2O + NADP(+)
REACT:R-HSA-2022403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)
REACT:R-SPO-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Schizosaccharomyces pombe)
REACT:R-SSC-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Sus scrofa)
RHEA:56542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol
RHEA:25841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-deoxy-D-glucuronate => 5-dehydro-2-deoxy-D-gluconate
REACT:R-CFA-5205861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Canis familiaris)
RHEA:17852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O
GO:0061690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoamidase activity
GO:0061690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipoyl-X-hydrolase
RHEA:48946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate
REACT:R-HSA-1225949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
REACT:R-BTA-2465890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDR2 binds collagen type I, II, III, V, X fibrils (Bos taurus)
REACT:R-CEL-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Caenorhabditis elegans)
REACT:R-PFA-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Plasmodium falciparum)
RHEA:58299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine
RHEA:44655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine
REACT:R-SSC-200646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic folate export across the plasma membrane (Sus scrofa)
RHEA:10083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrophloroglucinol + NADP(+) <=> 1,3,5-trihydroxybenzene + NADPH
REACT:R-HSA-9703433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligand-independent dimerization of FLT3 fusion proteins (Homo sapiens)
REACT:R-CEL-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Caenorhabditis elegans)
REACT:R-GGA-4546385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylates NR5A1 with SUMO2 (Gallus gallus)
GO:0103014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-keto ester reductase activity
REACT:R-DME-8951486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C4b (Drosophila melanogaster)
REACT:R-XTR-3322429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP monoubiquinates TLE (Xenopus tropicalis)
REACT:R-RNO-6801101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RABGGTA binds RABGGTB (Rattus norvegicus)
REACT:R-HSA-6783455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)
RHEA:48375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)
REACT:R-CFA-187552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Canis familiaris)
RHEA:16238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-peptidylproline (omega=180) => [protein]-peptidylproline (omega=0)
RHEA:37942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate
RHEA:23518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP
REACT:R-DRE-5578742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGO1,2:small RNA complexes interact with chromatin (Danio rerio)
REACT:R-GGA-9013437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD GAPs stimulate RHOD GTPase activity (Gallus gallus)
REACT:R-CFA-174235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdc20 (Canis familiaris)
RHEA:35550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:53078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine
REACT:R-CEL-450348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
RHEA:15795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin IXalpha + H(+) + NADPH => bilirubin IXalpha + NADP(+)
REACT:R-HSA-73946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive initiation after formation of the first phosphodiester bond (Homo sapiens)
RHEA:70844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-methionine(out) + Na(+)(out) => L-arginine(out) + L-methionine(in) + Na(+)(in)
REACT:R-SSC-1482656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is hydrolysed to 1-acyl LPA by PLA2[1] (Sus scrofa)
RHEA:55030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine
RHEA:68761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine
RHEA:18704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arsenite + H2O + 2 oxidized [azurin] <=> arsenate + 3 H(+) + 2 reduced [azurin]
RHEA:68201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoylglycerol + hexadecanoyl-CoA => 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA
RHEA:13902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(aminomethyl)urea => N-(hydroxymethyl)urea + NH4(+)
REACT:R-GGA-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Gallus gallus)
REACT:R-SSC-6809320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Sus scrofa)
REACT:R-MMU-5676597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Mus musculus)
REACT:R-BTA-5604929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated protein C binds Protein S (Bos taurus)
REACT:R-MMU-5635845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI proteins bind CDC73 (Mus musculus)
REACT:R-DDI-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Dictyostelium discoideum)
REACT:R-CFA-201445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Canis familiaris)
RHEA:61690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + L-threonyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-threonine
RHEA:42195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-XTR-5690669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD22 binds itself to form homo-oligomers (Xenopus tropicalis)
REACT:R-CEL-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Caenorhabditis elegans)
RHEA:44218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxyoctadecanoyl-CoA + AMP + diphosphate => 12-hydroxyoctadecanoate + ATP + CoA
REACT:R-CEL-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Caenorhabditis elegans)
REACT:R-MMU-8854329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D15 accelerates GTP hydrolysis by RAB7 (Mus musculus)
RHEA:36675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octacosanoyl-CoA + sphinganine = CoA + H(+) + N-(octacosanoyl)-sphinganine
REACT:R-SCE-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Saccharomyces cerevisiae)
REACT:R-SSC-416683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA3E binds to PLXND1 (Sus scrofa)
RHEA:48542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) => 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O
RHEA:12852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-[myosin light chain] <=> L-seryl-[myosin light chain] + phosphate
RHEA:48576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorocatechol + O2 = 3-chloro-cis,cis-muconate + 2 H(+)
REACT:R-BTA-9624798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LBR binds KPNB1 (Bos taurus)
REACT:R-SSC-170835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Sus scrofa)
REACT:R-SSC-2396007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRF3 is phosphorylated by TBK1 (Sus scrofa)
REACT:R-HSA-8850846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase1 hydrolyzes nucleoside triphosphates (Homo sapiens)
REACT:R-CEL-77584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Caenorhabditis elegans)
GO:0005004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-linked Eph receptor activity
GO:0005004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPI-linked ephrin receptor activity
REACT:R-CFA-937050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino ubiquitinates hp-IRAK1 (Canis familiaris)
GO:0106026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-tRNA(Ala) hydrolase activity
REACT:R-BTA-5688837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATXN3 deubiquitinates polyUb-PARK2 (Bos taurus)
REACT:R-SPO-165726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Ribosomal protein S6 by activated S6K1 (Schizosaccharomyces pombe)
RHEA:41529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-[ACP] + H(+) + NADH => NAD(+) + octanoyl-[ACP]
REACT:R-HSA-5250217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL2:GTP binds ARL2BP (Homo sapiens)
REACT:R-RNO-114392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Rattus norvegicus)
REACT:R-MMU-450257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
REACT:R-XTR-110138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)
REACT:R-DRE-2730692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN4/5/6 exchange Cl- for H+ (Danio rerio)
RHEA:11051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid
RHEA:63348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-amino acyl-L-cysteinyl-[protein] = (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate
RHEA:63348	skos:prefLabel	"thiazoline synthase"
RHEA:63348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thiazoline synthase"
REACT:R-XTR-9018894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Xenopus tropicalis)
GO:0097099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of egg white
GO:0097099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of albumen
REACT:R-CFA-70800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Canis familiaris)
REACT:R-MMU-916855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Mus musculus)
REACT:R-MMU-8854628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MYLIP dimer ubiquitinates VLDLR on Lys-839 (Mus musculus)
REACT:R-DDI-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Dictyostelium discoideum)
REACT:R-CFA-182988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sprouty lures CBL away from EGFR (Canis familiaris)
REACT:R-DDI-377186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Dictyostelium discoideum)
REACT:R-DME-1855163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Drosophila melanogaster)
REACT:R-SSC-8857549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HBEGF-bound EGFR forms a heterodimer with GPNMB (Sus scrofa)
RHEA:41286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-tetracosanoyl-sphing-4-enine <=> sphing-4-enine + tetracosanoate
RHEA:37949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
REACT:R-HSA-1500804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxynitrite is reduced by AhpE (Homo sapiens)
REACT:R-SSC-5634221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 binds TRAF2 within TNFR1 signaling complex (Sus scrofa)
RHEA:65114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aculene C + CO2 + H2O + succinate => 2-oxoglutarate + aculene D + O2
REACT:R-BTA-8878117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds ZFHX3 (Bos taurus)
REACT:R-MMU-428518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glypican-1 (GPC1) binds SLIT2 (Mus musculus)
REACT:R-BTA-8853800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARTN binds RET:GFRA1,GFRA3 (Bos taurus)
EC:1.7.3.1	skos:altLabel	"nitroethane reductase"
EC:1.7.3.1	skos:prefLabel	"nitroalkane oxidase"
EC:1.7.3.1	skos:altLabel	"nitroethane oxidase"
EC:1.7.3.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitroalkane oxidase"
EC:1.7.3.1	skos:altLabel	"NAO"
REACT:R-DRE-3239019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK5 (Danio rerio)
REACT:R-CEL-2046089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Caenorhabditis elegans)
REACT:R-CFA-1605717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Canis familiaris)
RHEA:16375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-4'-phosphopantothenate + ADP + H(+) => (R)-pantothenate + ATP
REACT:R-RNO-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Rattus norvegicus)
REACT:R-CEL-375151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NCAM1 with collagens (Caenorhabditis elegans)
REACT:R-HSA-5626270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)
REACT:R-MMU-201422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Mus musculus)
REACT:R-SSC-381518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAAP-A proteolyzes IGF:IGFBP4 (Sus scrofa)
RHEA:37161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate
REACT:R-XTR-70449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Xenopus tropicalis)
REACT:R-HSA-9632868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDKN1B is phosphorylated in response to estrogen (Homo sapiens)
REACT:R-DRE-8849085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RHOA:GTP (Danio rerio)
RHEA:53506	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine
REACT:R-SSC-3928656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-secretase cleaves EPHB2 (Sus scrofa)
REACT:R-GGA-429992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARN deadenylates mRNA (Gallus gallus)
REACT:R-SPO-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Schizosaccharomyces pombe)
RHEA:40609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + H(+) + tetradecanoate => 1-tetradecanoyl-sn-glycerol + H2O
REACT:R-DRE-6795460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGK1 phosphorylates MDM2 (Danio rerio)
GO:0046871	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylgalactosamine lectin
GO:0046871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylgalactosamine binding
REACT:R-CFA-5659781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRCA1 forms a heterodimer with BARD1 (Canis familiaris)
RHEA:29359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UMP = phosphate + uridine
REACT:R-DRE-74737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-IRS1,p-Y-IRS2 bind PI3K (Danio rerio)
REACT:R-DRE-8936584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Danio rerio)
EC:3.4.21.111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aqualysin 1"
EC:3.4.21.111	skos:altLabel	"caldolysin"
EC:3.4.21.111	skos:prefLabel	"aqualysin 1"
RHEA:36853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA
GO:0140297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	repressing transcription factor binding
GO:0140297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	transcription activator binding
GO:0140297	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	activating transcription factor binding
GO:0140297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-binding transcription factor binding
RHEA:42177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-GGA-141367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myristoylation of tBID by NMT1 (Gallus gallus)
RHEA:26220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:34328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + H(+) + NADPH + O2 => 1,4-benzoquinone + H2O + NADP(+) + nitrite
REACT:R-CEL-8952631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Caenorhabditis elegans)
RHEA:41338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-DRE-196840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3xPPCDC:3FMN decarboxylates PPC (Danio rerio)
REACT:R-DRE-1247649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AQP1 tetramer transports CO2 from cytosol to extracellular region (Danio rerio)
REACT:R-RNO-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Rattus norvegicus)
RHEA:47049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + shikimate => 3-dehydroshikimate + a quinol
RHEA:39668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)
RHEA:60444	skos:prefLabel	"cysteinylglycine-S-conjugate dipeptidase"
RHEA:60444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cysteinylglycine-S-conjugate dipeptidase"
RHEA:60444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine
REACT:R-RNO-2160932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 binds phosphorylated PARD6A (Rattus norvegicus)
REACT:R-CFA-8853429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PHLDA1 binds AURKA (Canis familiaris)
RHEA:16127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-fructose 6-phosphate + H(+) => ATP + D-fructose
GO:0086037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential
REACT:R-XTR-1482900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Xenopus tropicalis)
REACT:R-SPO-111898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of cPLA2 by ERK-2 (Schizosaccharomyces pombe)
RHEA:22387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O <=> 1D-myo-inositol hexakisphosphate + H(+) + phosphate
RHEA:67209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + melatonin => 5-methoxytryptamine + acetate
REACT:R-CFA-2022856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcNAc to heparan (Canis familiaris)
RHEA:17511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+) => H2O + thiamine
RHEA:42340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH
REACT:R-BTA-8849900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs1-3 bind each other in cis interactions (Bos taurus)
GO:0008388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	testosterone 15-alpha-hydroxylase activity
GO:0008388	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytochrome P450 CYP2A4
RHEA:13388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoate + H(+) <=> 2-undecanone + CO2
RHEA:71707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-phenylalanyl-L-phenylalanine(out) = H(+)(in) + L-phenylalanyl-L-phenylalanine(in)
GO:0052759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity
GO:0052759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme F420-dependent 2,4,6-trinitrophenol-hydride-Meisenheimer-complex hydride transferase activity
REACT:R-BTA-6804229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JMY, TTC5 and EP300 bind (Bos taurus)
RHEA:71950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-aspartate(out) + 3 Na(+)(out) <=> N-acetyl-L-aspartate(in) + 3 Na(+)(in)
REACT:R-MMU-5607023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IXa associates with cell membrane (Mus musculus)
REACT:R-RNO-450187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated within the TAK1 complex (Rattus norvegicus)
REACT:R-DME-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Drosophila melanogaster)
RHEA:60272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:60692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-enal + H2O + NADP(+) = (E)-non-2-enoate + 2 H(+) + NADPH
REACT:R-DME-5694428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LMAN family proteins bind glycosylated cargo (Drosophila melanogaster)
REACT:R-CEL-196017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin is recruited to the gap junction plaque (Caenorhabditis elegans)
REACT:R-XTR-6793666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 translocates to the nucleus (Xenopus tropicalis)
REACT:R-GGA-375395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C5a receptor binds C5a anaphylatoxin (Gallus gallus)
RHEA:49747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyviolaceinate + H(+) + O2 <=> CO2 + deoxyviolacein + H2O
REACT:R-BTA-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Bos taurus)
REACT:R-HSA-2066779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Homo sapiens)
REACT:R-DRE-4570499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Danio rerio)
REACT:R-RNO-5696491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CNTF binds CNTFR complex (Rattus norvegicus)
RHEA:32233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + NADPH + phosphate => (6S)-NADPHX + ATP
RHEA:50654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)propylmaleate + H2O => 2-(3-methylsulfanyl)propylmalate
REACT:R-CFA-71593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Canis familiaris)
REACT:R-GGA-1236954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides by IRAP in endocytic vesicles (Gallus gallus)
EC:1.11.2.3	skos:altLabel	"plant peroxygenase"
EC:1.11.2.3	skos:prefLabel	"plant seed peroxygenase"
EC:1.11.2.3	skos:altLabel	"soybean peroxygenase"
EC:1.11.2.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plant seed peroxygenase"
RHEA:37340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O => (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)
REACT:R-RNO-422048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acyl Ghrelin and C-Ghrelin are secreted (Rattus norvegicus)
REACT:R-MMU-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Mus musculus)
REACT:R-CFA-1562626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)
REACT:R-DRE-6782106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates SNX3, CFTR (Danio rerio)
RHEA:15458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => catechol + H(+) + NADH
RHEA:43715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dodecanoate + H(+) <=> diphosphate + dodecanoyl-AMP
REACT:R-SSC-1247665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Sus scrofa)
EC:5.6.1.-	skos:prefLabel	"Enzymes altering polypeptide conformation or assembly"
EC:5.6.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Enzymes altering polypeptide conformation or assembly"
REACT:R-HSA-9792608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 exchanges UDP-D-glucose for UMP (Homo sapiens)
RHEA:37106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)
REACT:R-DRE-8943987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCUBE1, SCUBE3 oligomerize (Danio rerio)
REACT:R-BTA-5654633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS bind to PPTN11 (Bos taurus)
RHEA:35983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
RHEA:13491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	berberine + 2 H2O2 => (S)-canadine + H(+) + 2 O2
REACT:R-DDI-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Dictyostelium discoideum)
REACT:R-DME-432164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca2+ influx into the post-synaptic cell (Drosophila melanogaster)
GO:0080025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3,5-bisphosphate binding
GO:0080025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PtdIns(3,5)P2 binding
REACT:R-SPO-9603279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDK1 and AKT to the membrane (Schizosaccharomyces pombe)
RHEA:29319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phosphoethanolamine = ethanolamine + H(+) + sn-glycerol 3-phosphate
RHEA:46011	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + NAD(+) + pentanal <=> H(+) + NADH + pentanoyl-CoA
REACT:R-DRE-5654692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
REACT:R-PFA-8853503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Plasmodium falciparum)
REACT:R-RNO-2029476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Role of myosins in phagosome formation (Rattus norvegicus)
RHEA:11978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5a,11a-dehydrotetracycline + H2O + NADP(+) => anhydrotetracycline + H(+) + NADPH + O2
REACT:R-SSC-1234177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)
REACT:R-HSA-1067651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)
RHEA:35006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-fucose(in) <=> L-fucose(out)
REACT:R-DME-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Drosophila melanogaster)
GO:1904680	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide uptake permease activity
GO:1904680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glutathione is taken up by the bacterium (Homo sapiens)
GO:1904680	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide transporter activity
GO:1904680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide transmembrane transporter activity
REACT:R-DRE-446701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4-activated IRAK1 autophosphorylates (Danio rerio)
RHEA:64762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanethiol + NH4(+) + pyruvate => H2O + S-ethyl-L-cysteine
REACT:R-DRE-9748979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Danio rerio)
RHEA:30459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol = (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone
REACT:R-SSC-5205824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)
RHEA:29376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + H2O => adenosine + phosphate
RHEA:19779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + H(+) + L-1-piperideine-6-carboxylate => A + L-pipecolate
RHEA:21448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrogenase"
RHEA:21448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate
RHEA:21448	skos:prefLabel	"nitrogenase"
GO:0004756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	selenium donor protein activity
GO:0004756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenophosphate synthase activity
GO:0004756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenide, water dikinase activity
GO:0004756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	selenide,water dikinase activity
GO:0004756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:selenide, water phosphotransferase activity
GO:0004756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	selenophosphate synthetase activity
REACT:R-BTA-8851890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET phosphorylates SHC1-2 (Bos taurus)
RHEA:14697	skos:prefLabel	"farnesol dehydrogenase"
RHEA:14697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"farnesol dehydrogenase"
RHEA:14697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH
REACT:R-CEL-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Caenorhabditis elegans)
RHEA:49209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]
REACT:R-RNO-9664879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM:PEX5 binds ATM (Rattus norvegicus)
RHEA:21568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose
RHEA:21568	skos:prefLabel	"lacto-N-biosidase"
RHEA:21568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lacto-N-biosidase"
RHEA:21568	skos:altLabel	"oligosaccharide lacto-N-biosylhydrolase"
GO:0050458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decylhomocitrate synthase activity
GO:0050458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity
GO:0050458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)
GO:0050458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)
GO:0050458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-decylhomocitrate synthase activity
REACT:R-HSA-8984001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL35 binds IL27RA:IL12RB2 receptor (Homo sapiens)
RHEA:22930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoyl-CoA + acetate => 4-acetamidobutanoyl-CoA + H2O
RHEA:32946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + CDP-ethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
RHEA:53498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O
REACT:R-DME-1483121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS1 (Drosophila melanogaster)
REACT:R-CEL-1482811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Caenorhabditis elegans)
RHEA:33044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,4R)-camphor + H(+) + NADPH + O2 => (+)-6-exo-hydroxycamphor + H2O + NADP(+)
REACT:R-BTA-159752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Bos taurus)
RHEA:52548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-threonate 2-dehydrogenase"
RHEA:52548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonate + NAD(+) = 2-dehydro-L-erythronate + H(+) + NADH
RHEA:52548	skos:prefLabel	"L-threonate 2-dehydrogenase"
RHEA:28806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-ascorbate 6-phosphate <=> 3-dehydro-L-gulonate 6-phosphate
GO:1902051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-Delta(4)-dafachronate binding
REACT:R-HSA-5654423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
REACT:R-HSA-9731708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp10:nsp14 binds to ExoN inhibitors (Homo sapiens)
REACT:R-MMU-8987266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Mus musculus)
REACT:R-RNO-205117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR:NADE promotes caspase2/3 activation (Rattus norvegicus)
REACT:R-SCE-9659611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANO1 inhibitors bind ANO1 (Saccharomyces cerevisiae)
REACT:R-CEL-5368580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Caenorhabditis elegans)
RHEA:25862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+) => GTP + H2O
REACT:R-RNO-5667008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds RHPN1 or RHPN2 (Rattus norvegicus)
GO:0050290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingomyelin phosphodiesterase D activity
GO:0050290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphingomyelin ceramide-phosphohydrolase activity
GO:0050290	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphingomyelinase D
REACT:R-SSC-9706298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to CSK (Sus scrofa)
REACT:R-CFA-4086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NPM1 with SUMO2,3 (Canis familiaris)
REACT:R-CFA-444498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thyrotropin-releasing hormone receptor binds thyrotropin (Canis familiaris)
EC:3.4.24.17	skos:altLabel	"proteoglycanase"
EC:3.4.24.17	skos:prefLabel	"stromelysin 1"
EC:3.4.24.17	skos:altLabel	"transin"
EC:3.4.24.17	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stromelysin 1"
EC:3.4.24.17	skos:altLabel	"matrix metalloproteinase 3"
REACT:R-BTA-508292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds IL2RB (Bos taurus)
RHEA:69789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2-aminophenyl)succinyl-CoA + succinate => (2-aminophenyl)succinate + succinyl-CoA
REACT:R-GGA-201639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of GAS2 (Gallus gallus)
REACT:R-BTA-9027043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)
GO:0003730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA 3'-UTR binding
GO:0003730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA 3' UTR binding
REACT:R-MMU-432232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Mus musculus)
RHEA:32048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-pentaphosphate + AMP + 2 H(+)
REACT:R-CFA-8982021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) in G alpha (z):RGS complex is inactivated (Canis familiaris)
REACT:R-CFA-2247512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Canis familiaris)
RHEA:16327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + H(+) + UTP
REACT:R-GGA-1632857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates AMBRA1:BECN1 complex (Gallus gallus)
RHEA:68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + NADP(+) + propanal => ATP + H(+) + NADPH + propanoate
REACT:R-BTA-481010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet dense granule membrane components (Bos taurus)
REACT:R-XTR-9028255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGS2 dimer oxidises EPA to PGH3 (Xenopus tropicalis)
RHEA:50489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]
RHEA:46087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 1-phosphate <=> glycerol + phosphate
RHEA:35850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + sphing-4-enine <=> ADP + H(+) + sphing-4-enine 1-phosphate
RHEA:41873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydodecanoyl-[ACP] + NADP(+)
RHEA:45806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + L-glutamine hydroxamate + phosphate => ATP + hydroxylamine + L-glutamate
REACT:R-CEL-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)
REACT:R-MMU-9674127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Mus musculus)
REACT:R-SSC-159179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Sus scrofa)
RHEA:51835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)
REACT:R-DRE-1028820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of VAF (virus-activated factor) complex (Danio rerio)
RHEA:13108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol 2-phosphate + H2O <=> glycerol + phosphate
REACT:R-BTA-5675948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFRSF6B binds TNFSF6,14,15 (Bos taurus)
REACT:R-SCE-3299682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Saccharomyces cerevisiae)
RHEA:15217	skos:prefLabel	"ecdysone O-acyltransferase"
RHEA:15217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ecdysone O-acyltransferase"
RHEA:15217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ecdysone + hexadecanoyl-CoA = CoA + ecdysone hexadecanoate
GO:0051060	skos:prefLabel	"pullulanase"
GO:0051060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	limit dextrinase
GO:0051060	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	debranching enzyme activity
GO:0051060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pullulan alpha-1,6-glucanohydrolase activity
GO:0051060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amylopectin 6-glucanohydrolase activity
GO:0051060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	bacterial debranching enzyme
GO:0051060	skos:altLabel	"limit dextrinase"
GO:0051060	skos:altLabel	"amylopectin 6-glucanohydrolase"
GO:0051060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-dextrin endo-1,6-alpha-glucosidase activity
GO:0051060	skos:altLabel	"pullulan 6-glucanohydrolase"
GO:0051060	skos:altLabel	"alpha-dextrin endo-1,6-alpha-glucosidase"
GO:0051060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pullulanase activity
GO:0051060	skos:altLabel	"debranching enzyme"
GO:0051060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pullulanase"
GO:0051060	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	R-enzyme
GO:0051060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pullulan 6-glucanohydrolase activity
GO:0034016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity
GO:0034016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyenoic fatty acid isomerase activity
GO:0034016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity
GO:0034016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity
GO:0034016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PFI
GO:0034016	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity
RHEA:45820	skos:prefLabel	"succinyl-CoA:mesaconate CoA transferase"
RHEA:45820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate
RHEA:45820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinyl-CoA:mesaconate CoA transferase"
REACT:R-PFA-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Plasmodium falciparum)
REACT:R-CEL-9725706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A3 binds SLC12A3 inhibitors (Caenorhabditis elegans)
RHEA:23422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + phosphate => alpha,alpha-trehalose 6-phosphate + H2O
RHEA:21588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetyl-gamma-glutamyl-phosphate reductase"
RHEA:21588	skos:prefLabel	"N-acetyl-gamma-glutamyl-phosphate reductase"
RHEA:21588	skos:altLabel	"NAGSA dehydrogenase"
RHEA:21588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH
RHEA:21588	skos:altLabel	"N-acetyl-glutamate semialdehyde dehydrogenase"
REACT:R-MMU-9640175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)
REACT:R-SSC-196086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Sus scrofa)
REACT:R-RNO-9611721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1-agonists bind ADRB1 (Rattus norvegicus)
REACT:R-BTA-5672329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IQGAP1 binds CLIP1 and microtubules (Bos taurus)
REACT:R-RNO-8948232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Rattus norvegicus)
REACT:R-HSA-4755526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates NR4A2 with SUMO2,3 (Homo sapiens)
RHEA:54266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2
GO:0001918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesylated protein binding
REACT:R-HSA-169680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
RHEA:30407	skos:prefLabel	"photosystem I"
RHEA:30407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"photosystem I"
RHEA:30407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]
RHEA:37087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine
RHEA:44455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
GO:0005503	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	vitamin A binding
GO:0005503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	visual yellow binding
GO:0005503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans retinal binding
GO:0005503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans retinal binding
GO:0005503	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthopsin
GO:0005503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans retinaldehyde binding
REACT:R-SSC-9695917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPHK2 binds SPHK2 inhibitors (Sus scrofa)
REACT:R-GGA-8867756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
GO:0080074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine:caffeoyl CoA N-acyltransferase activity
REACT:R-SSC-198983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NKG2D homodimer interacting with ligands (Sus scrofa)
REACT:R-HSA-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Homo sapiens)
REACT:R-GGA-9617370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α1-antagonists bind ADRA1A,B,D (Gallus gallus)
RHEA:30717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-linalool => (2E)-geraniol
REACT:R-XTR-1602488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP13 by plasmin and trypsin (Xenopus tropicalis)
REACT:R-XTR-176646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Xenopus tropicalis)
RHEA:31443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-sedoheptulose 7-phosphate = ADP + D-sedoheptulose 1,7-bisphosphate + H(+)
REACT:R-SSC-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Sus scrofa)
REACT:R-CFA-9700998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAP1 disrupts the BRCA1:BARD1 heterodimer (Canis familiaris)
RHEA:29614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADP(+) + nitrous oxide <=> H(+) + NADPH + 2 nitric oxide
REACT:R-HSA-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Homo sapiens)
GO:0062203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + peregrinol diphosphate = diphosphate + viteagnusin D
GO:0062203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Viteagnusin D synthase activity
REACT:R-HSA-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Homo sapiens)
REACT:R-GGA-6798743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule membrane proteins (Gallus gallus)
RHEA:62510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:52917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP
EC:1.3.1.79	skos:altLabel	"arogenic dehydrogenase"
EC:1.3.1.79	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arogenate dehydrogenase [NAD(P)(+)]"
EC:1.3.1.79	skos:altLabel	"cyclohexadienyl dehydrogenase"
EC:1.3.1.79	skos:altLabel	"pretyrosine dehydrogenase"
EC:1.3.1.79	skos:prefLabel	"arogenate dehydrogenase [NAD(P)(+)]"
GO:0000384	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lariat formation, 5'-splice site cleavage
GO:0000384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	first spliceosomal transesterification activity
REACT:R-XTR-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Xenopus tropicalis)
RHEA:63551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin-(1-9) + H2O <=> angiotensin-(1-7) + L-phenylalanyl-L-histidine
REACT:R-CFA-170671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)
REACT:R-DRE-174097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Emi1 with Cdh1 (Danio rerio)
REACT:R-SSC-917936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCOLN1 transports Fe2+ from endosome lumen to cytosol (Sus scrofa)
REACT:R-MMU-6797553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protein 4.1 binds CASK (Mus musculus)
REACT:R-RNO-114252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase-3 by the apoptosome (Rattus norvegicus)
RHEA:26270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-2 + 3 H(+) => Co(2+) + precorrin-2
REACT:R-SSC-6814555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrator complex processes the 3' end of snRNA (Sus scrofa)
REACT:R-CEL-5654578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1 phosphorylates FRS3 (Caenorhabditis elegans)
REACT:R-CFA-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Canis familiaris)
RHEA:34717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+) => 15-methylhexadecasphing-4-enine + ATP
RHEA:13854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylene-L-glutamate + ATP + NH4(+) => 4-methylene-L-glutamine + AMP + diphosphate + H(+)
REACT:R-DRE-5692779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S182 MAPKAPK5 phosphorylates FOXO1 (Danio rerio)
REACT:R-DRE-1254386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 forms a complex with estrogen receptor ESR1 (Danio rerio)
REACT:R-DRE-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Danio rerio)
REACT:R-RNO-446634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 is activated by autophosphorylation (Rattus norvegicus)
REACT:R-DRE-5654612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)
RHEA:62866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine
REACT:R-SSC-110141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Sus scrofa)
RHEA:46022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[pyruvate, water dikinase]-phosphate + AMP + H(+) => [pyruvate, water dikinase] + ADP
REACT:R-DRE-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Danio rerio)
RHEA:67947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexadecanoate + O2 <=> 2-oxohexadecanoate + H2O2
RHEA:46323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-chol-5-ene-24-oyl-CoA + A <=> 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2
REACT:R-BTA-174122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Bos taurus)
GO:0046565	skos:prefLabel	"3-dehydroshikimate dehydratase"
GO:0046565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydroshikimate dehydratase"
GO:0046565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroshikimate dehydratase activity
GO:0046565	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O
RHEA:23833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-D-mannosamine + ATP => ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)
RHEA:25631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + laricitrin + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine
REACT:R-MMU-8939201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR dimerizes (Mus musculus)
EC:4.2.2.16	skos:altLabel	"2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride)"
EC:4.2.2.16	skos:altLabel	"levan fructotransferase"
EC:4.2.2.16	skos:prefLabel	"levan fructotransferase (DFA-IV-forming)"
EC:4.2.2.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"levan fructotransferase (DFA-IV-forming)"
REACT:R-XTR-8856813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAK1 phosphorylates AP-2 mu subunit at T156 (Xenopus tropicalis)
RHEA:57523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:54055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + tau-cadinol
RHEA:42317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-GGA-5618073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Gallus gallus)
REACT:R-MMU-8983845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dissociates from IL6ST:IL6ST (Mus musculus)
REACT:R-GGA-8853774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Gallus gallus)
REACT:R-SPO-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Schizosaccharomyces pombe)
RHEA:53646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-corvol ether B + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:51554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-xylo-3-hexulose + NADPH => D-sorbitol + NADP(+)
GO:0016795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoric triester hydrolase activity
GO:0016795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Phosphoric triester hydrolases"
GO:0016795	skos:prefLabel	"Phosphoric triester hydrolases"
REACT:R-XTR-1855200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Xenopus tropicalis)
REACT:R-MMU-5693593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop extension by DNA polymerases (Mus musculus)
REACT:R-MMU-8982012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Mus musculus)
REACT:R-MMU-418574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Mus musculus)
REACT:R-BTA-6782820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates SUDS3 (Bos taurus)
REACT:R-DME-2744361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic Cl- to extracellular region (Drosophila melanogaster)
REACT:R-HSA-9653249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of factor XII variant by activated thrombin (Homo sapiens)
REACT:R-HSA-114544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p115-RhoGEF activation of RHOA (Homo sapiens)
REACT:R-BTA-1470012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation and translocation of STATs to the nucleus (Bos taurus)
REACT:R-MMU-9021601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Mus musculus)
GO:0036393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiocyanate peroxidase activity
GO:0036393	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	lactoperoxidase activity
REACT:R-CFA-418850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Cdc42 (Canis familiaris)
REACT:R-SSC-9698170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Sus scrofa)
RHEA:39742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydodecanoate + H(+) + NADPH + O2 <=> 3,12-dihydroxydodecanoate + H2O + NADP(+)
RHEA:20700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+)
RHEA:20700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + lipid A disaccharide (E. coli) = ADP + H(+) + lipid IVA (E. coli)
RHEA:20700	skos:prefLabel	"tetraacyldisaccharide 4'-kinase"
RHEA:20700	skos:altLabel	"lipid-A 4'-kinase"
RHEA:20700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetraacyldisaccharide 4'-kinase"
REACT:R-XTR-4332235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds TGFBR2 (Xenopus tropicalis)
REACT:R-BTA-1889981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Bos taurus)
REACT:R-DRE-9679477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFA-165 dimer binds VEGFA inhibitors (Danio rerio)
RHEA:56433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate
REACT:R-BTA-8848355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA4 hydrolyzes retinyl palmitate (Bos taurus)
RHEA:66942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B => acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine
RHEA:49190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-vinylbacteriochlorophyllide d + H2O => a bacteriochlorophyllide d
REACT:R-HSA-9615801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds IRAK1 gene (Homo sapiens)
RHEA:51243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate
REACT:R-CFA-450827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Canis familiaris)
RHEA:52505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:68888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxybenzoate + ATP + H(+) + NADPH = 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)
RHEA:56801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide => cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]
RHEA:10123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine in double-stranded RNA + H(+) + H2O <=> inosine in double-stranded RNA + NH4(+)
RHEA:40184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O2
REACT:R-SSC-429955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR4-NOT complex deadenylates mRNA (Sus scrofa)
RHEA:29892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-histidine(out) => ADP + H(+) + L-histidine(in) + phosphate
REACT:R-DME-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Drosophila melanogaster)
REACT:R-MMU-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Mus musculus)
REACT:R-BTA-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Bos taurus)
RHEA:71236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] => [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]
REACT:R-HSA-870477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Homo sapiens)
RHEA:53272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-L-gluconate = keto-D-tagaturonate
RHEA:63436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)
REACT:R-DME-2316429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
RHEA:54931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)
REACT:R-CFA-6797913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARDH:FAD oxidatively demethylates SARC to Gly (Canis familiaris)
REACT:R-MMU-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Mus musculus)
REACT:R-MMU-8981355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 binds RAS:GTP (Mus musculus)
REACT:R-RNO-5649883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB-mediated DNA strand displacement synthesis (Rattus norvegicus)
RHEA:10696	skos:prefLabel	"long-chain fatty acid adenylyltransferase FadD28"
RHEA:10696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + holo-[mycocerosate synthase] = AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]
RHEA:10696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"long-chain fatty acid adenylyltransferase FadD28"
REACT:R-BTA-3245898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN1 binds correnoids in the circulation (Bos taurus)
REACT:R-MMU-450971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Mus musculus)
RHEA:59091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine
RHEA:61599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbD protein]-dithiol + [thioredoxin]-disulfide <=> [DsbD protein]-disulfide + [thioredoxin]-dithiol
RHEA:57477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + H2O2 => 2-hydroxydodecanoate + H2O
RHEA:55235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O
REACT:R-GGA-2752067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BESTs transport cytosolic HCO3- to extracellular region (Gallus gallus)
REACT:R-CFA-6782106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 deubiquitinates SNX3, CFTR (Canis familiaris)
REACT:R-CEL-9603982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to LeA to form LeB (Caenorhabditis elegans)
RHEA:65504	skos:prefLabel	"[mycofactocin precursor peptide] peptidase"
RHEA:65504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[mycofactocin precursor peptide] peptidase"
RHEA:65504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O = 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine
REACT:R-DRE-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Danio rerio)
GO:0070866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sterol-dependent protein binding
REACT:R-DDI-73598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Dictyostelium discoideum)
REACT:R-GGA-71676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Gallus gallus)
RHEA:26249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + levopimaradienol + NADPH + O2 = 2 H2O + levopimaradienal + NADP(+)
RHEA:48480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP
RHEA:48460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate
REACT:R-BTA-3341397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)
REACT:R-CFA-992703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitofusins trans-interact linking mitochondria prior to fusion (Canis familiaris)
RHEA:51561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-bulbocapnine + S-adenosyl-L-methionine => (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-374922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Noradrenalin synaptic vesicle docking and priming (Sus scrofa)
GO:0005113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ptc binding
GO:0005113	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ptc ligand
GO:0005113	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	patched ligand
GO:0005113	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	patched binding
GO:0017040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acylsphingosine amidohydrolase activity
GO:0017040	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	glycosphingolipid ceramide deacylase
GO:0017040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acylsphingosine deacylase activity
REACT:R-SCE-1482825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Saccharomyces cerevisiae)
REACT:R-DME-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Drosophila melanogaster)
REACT:R-DME-6805122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB binds TP53 (Drosophila melanogaster)
REACT:R-MMU-188002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Rab5-mediated recruitment of class III PI3K to TLR9 (Mus musculus)
RHEA:28920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(in) + L-glutamate(out) => 4-aminobutanoate(out) + L-glutamate(in)
RHEA:31024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	squalene => dammara-20,24-diene
REACT:R-XTR-9663511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL binds GSTA1, FABP1 (Xenopus tropicalis)
REACT:R-MMU-749446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Mus musculus)
EC:3.2.1.159	skos:prefLabel	"alpha-neoagaro-oligosaccharide hydrolase"
EC:3.2.1.159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha-neoagaro-oligosaccharide hydrolase"
EC:3.2.1.159	skos:altLabel	"alpha-neoagarooligosaccharide hydrolase"
EC:3.2.1.159	skos:altLabel	"alpha-NAOS hydrolase"
REACT:R-MMU-6805399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAF1 phosphorylates TP53 (Mus musculus)
REACT:R-XTR-9753634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGT dimers hydrolyse APAP-SG (Xenopus tropicalis)
REACT:R-RNO-5690080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP3,SAGA deubiquitinate Histone H2A,H2B (Rattus norvegicus)
GO:0010333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terpene synthase activity
RHEA:44165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O => adenine + D-ribose 5-triphosphate
RHEA:43223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:62068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose 6-phosphate + NADP(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
GO:0001070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-binding transcription regulator activity
GO:0001070	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA binding transcription factor activity
GO:0001070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA binding transcription regulator activity
REACT:R-DME-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Drosophila melanogaster)
REACT:R-CFA-3781023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPP1R3C binds to glycogen:GYG1:GYS1 (Canis familiaris)
GO:0047972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPase activity
GO:0047972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinopropionase activity
GO:0047972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPH
GO:0047972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-guanidinopropanoate + H2O = beta-alanine + urea
GO:0047972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"guanidinopropionase"
GO:0047972	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-guanidinopropanoate amidinopropionase activity
GO:0047972	skos:prefLabel	"guanidinopropionase"
RHEA:28328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucuronate + H(+) + wogonin => H2O + wogonin 7-O-beta-D-glucuronate
RHEA:16812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate
REACT:R-HSA-1306965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Homo sapiens)
REACT:R-MMU-9020251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Mus musculus)
REACT:R-RNO-1234181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
RHEA:57833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxopentanoate + H2O + NADP(+) => glutarate + 2 H(+) + NADPH
RHEA:58135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine
GO:0080076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity
REACT:R-HSA-433698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
REACT:R-BTA-4827383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Bos taurus)
REACT:R-SSC-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Sus scrofa)
RHEA:71032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(in) + L-phenylalanine(out) => L-cysteine(out) + L-phenylalanine(in)
REACT:R-CFA-6785933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT8 transfers Gal from UDP-Gal to CERA (Canis familiaris)
REACT:R-BTA-158959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Bos taurus)
REACT:R-GGA-9674531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AAMP binds EGFR (Gallus gallus)
RHEA:53025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + H2O + L-arginine => 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)
RHEA:12026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + O-sinapoylcholine => 1-O-(trans-sinapoyl)-beta-D-glucose + choline
REACT:R-GGA-8953946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Gallus gallus)
REACT:R-BTA-9020257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Bos taurus)
REACT:R-RNO-8931981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ESR1 (Rattus norvegicus)
REACT:R-MMU-5577234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Mus musculus)
REACT:R-DRE-1168643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCP ubiquitinylates IkB (Danio rerio)
RHEA:35511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-2,4-diaminobutanoate => (2S)-2-acetamido-4-aminobutanoate + H2O
REACT:R-HSA-1015702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of IFN-induced genes (Homo sapiens)
REACT:R-MMU-204779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 with Ang1 (Mus musculus)
REACT:R-HSA-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)
REACT:R-BTA-994106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HP1 alpha binds Histone H3K9(me)3 (Bos taurus)
REACT:R-DME-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)
RHEA:30256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 a ubiquinol + O2 => 2 a ubiquinone + 2 H2O
GO:0047294	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol phosphate geranylgeranyltransferase activity
GO:0047294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoglycerol geranylgeranyltransferase activity
GO:0047294	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity
GO:0047294	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	geranylgeranyl-transferase activity
RHEA:43650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctadecanoyl-[ACP] + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-[ACP]
REACT:R-HSA-6787811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HAO2 tetramer oxidises 2OH-PALM (Homo sapiens)
REACT:R-HSA-265428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alpha9beta1 with VCAM1 (Homo sapiens)
REACT:R-DME-5690159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates RIPK1,DDX58 (Drosophila melanogaster)
RHEA:45781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
RHEA:43462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA => dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA
GO:0034544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-ACOHDA hydrolase activity
REACT:R-PFA-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Plasmodium falciparum)
REACT:R-RNO-9756180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Rattus norvegicus)
RHEA:24545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-lysyl-[protein] + O2 => (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)
RHEA:51795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + salicylate <=> 2,3-dihydroxybenzoate + H2O + NAD(+)
REACT:R-DRE-917807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Danio rerio)
REACT:R-MMU-5693598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates NBN (Mus musculus)
REACT:R-BTA-450358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Bos taurus)
RHEA:21092	skos:prefLabel	"12-hydroxydihydrochelirubine 12-O-methyltransferase"
RHEA:21092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-hydroxydihydrochelirubine + S-adenosyl-L-methionine = dihydromacarpine + H(+) + S-adenosyl-L-homocysteine
RHEA:21092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"12-hydroxydihydrochelirubine 12-O-methyltransferase"
REACT:R-MMU-5362522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDHs oxidise atRAL to atRA (Mus musculus)
RHEA:57767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dinitrotoluene + NADH + O2 <=> 3-methyl-4-nitrocatechol + NAD(+) + nitrite
RHEA:44808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) = 2-demethylmenaquinol-10 + CO2 + diphosphate
RHEA:65513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 => 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2
REACT:R-SSC-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Sus scrofa)
REACT:R-RNO-2424476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAC1 by VAV2/3 (Rattus norvegicus)
RHEA:57245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + H(+) + lactate
REACT:R-DME-77345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)
REACT:R-CFA-190261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3c binds to FGF (Canis familiaris)
RHEA:45240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase"
RHEA:45240	skos:altLabel	"3,5-tetradecadienoyl-CoA isomerase"
RHEA:45240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA
RHEA:45240	skos:prefLabel	"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase"
REACT:R-RNO-9731590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Rattus norvegicus)
REACT:R-CFA-74215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Canis familiaris)
RHEA:58620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate
REACT:R-DME-442291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV2 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)
REACT:R-XTR-428585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)
REACT:R-DRE-2090085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGSNAT oligomer acetylates Heparan chain(1) (Danio rerio)
REACT:R-GGA-888572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Gallus gallus)
RHEA:21522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + 2 Fe(II)-[cytochrome b1] + H(+) => 2 Fe(III)-[cytochrome b1] + formate
REACT:R-RNO-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Rattus norvegicus)
REACT:R-DRE-548814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Danio rerio)
RHEA:62737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate
REACT:R-XTR-2028692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK4 (p-MST1) by caspase 3 (Xenopus tropicalis)
REACT:R-BTA-70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Bos taurus)
REACT:R-MMU-2396009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STING binds c-di-GMP (Mus musculus)
RHEA:22654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O
EC:3.4.21.32	skos:altLabel	"collagenolytic protease"
EC:3.4.21.32	skos:prefLabel	"brachyurin"
EC:3.4.21.32	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"brachyurin"
REACT:R-DDI-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)
REACT:R-SSC-5607750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Sus scrofa)
GO:0034560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bisphenol A hydroxylase A activity
GO:0070095	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	D-fructose 6-phosphate binding
GO:0070095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 6-phosphate binding
GO:0070095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose-6-phosphate binding
REACT:R-RNO-6788650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Rattus norvegicus)
RHEA:67342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside) => malonyl-CoA + quercetin 3-O-beta-D-glucoside
RHEA:63776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine
GO:0102468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	wogonin 7-O-glucuronosyltransferase activity
REACT:R-HSA-2395302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysino-5-ketonorleucine cross-links (Homo sapiens)
RHEA:65083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] <=> asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-3560802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker (Homo sapiens)
GO:0004117	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	calmodulin-activated cyclic-nucleotide dual specificity phosphodiesterase activity
GO:0004117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0004117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)
RHEA:29320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycero-3-phosphoethanolamine => ethanolamine + H(+) + sn-glycerol 3-phosphate
REACT:R-RNO-2428926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Rattus norvegicus)
RHEA:41967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + O2 <=> (2E)-butenoyl-CoA + H2O2
REACT:R-BTA-190326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR4 (Bos taurus)
RHEA:68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfopropanediol <=> 3-oxopropane-1-sulfonate + H2O
RHEA:66931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O <=> a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)
RHEA:63272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)
RHEA:48427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP
RHEA:48422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GM1 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E))
REACT:R-XTR-5678327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIOX oxidises Ins to GlcA (Xenopus tropicalis)
RHEA:45762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP + H(+) + rhodomycin D => dTDP-beta-L-daunosamine + epsilon-rhodomycinone
RHEA:34518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP
RHEA:67372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-seryl-L-threonine = L-serine + L-threonine
REACT:R-CFA-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Canis familiaris)
RHEA:47883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dioctanoylglycerol + H2O <=> H(+) + octanoate + octanoylglycerol
RHEA:15077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-[(R)-pantothenoyl]-L-cysteine = (R)-pantetheine + CO2
RHEA:15077	skos:prefLabel	"pantothenoylcysteine decarboxylase"
RHEA:15077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pantothenoylcysteine decarboxylase"
RHEA:15077	skos:altLabel	"N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase"
REACT:R-DME-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Drosophila melanogaster)
REACT:R-XTR-5654587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS phosphorylates PPTN11 (Xenopus tropicalis)
RHEA:50063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycochenodeoxycholate(in) + H2O <=> ADP + glycochenodeoxycholate(out) + H(+) + phosphate
GO:1905172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA-induced silencing complex binding
GO:1905172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC complex binding
RHEA:25766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-3-methylmalate + NAD(+) <=> 3-carboxy-2-oxobutanoate + H(+) + NADH
REACT:R-CFA-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Canis familiaris)
RHEA:48018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite => 4-methyl-5-nitrocatechol + NADH + O2
REACT:R-HSA-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Homo sapiens)
RHEA:38799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
RHEA:71073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-cysteine(in) => L-arginine(in) + L-cysteine(out)
REACT:R-BTA-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Bos taurus)
REACT:R-BTA-8848606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates PXN (Bos taurus)
REACT:R-MMU-8866601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Mus musculus)
RHEA:15580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + uridine <=> D-ribose + uracil
REACT:R-DRE-5662662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosinase oxidises tyrosine to dopaquinone (Danio rerio)
RHEA:49753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NAD(+) + proviolacein
RHEA:47950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + thiamine => H2O + thiamine phosphate
REACT:R-HSA-9035960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP27A1 does not 27-hydroxylate 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)
GO:0047383	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity
GO:0047383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinodeoxy-scyllo-inositol-4-phosphatase activity
GO:0047383	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity
GO:0047383	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-guanidino-scyllo-inositol 4-phosphatase activity
RHEA:37472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanoyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine
REACT:R-DME-5675470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC2/3 (cIAP1/2) is autoubiquitinated (Drosophila melanogaster)
REACT:R-SSC-416588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rho by LARG and PDZ-RhoGEF (Sus scrofa)
RHEA:69571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate + NH4(+)
REACT:R-DRE-482619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Danio rerio)
REACT:R-RNO-68603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC5 binds ORC2:ORC3 (Rattus norvegicus)
RHEA:68720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0010490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-4-keto-rhamnose-4-keto-reductase activity
RHEA:42813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + octadecanoyl-CoA => cholesteryl octadecanoate + CoA
RHEA:17024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + pyruvate <=> L-alanine + phosphonoacetaldehyde
REACT:R-CEL-111264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of nucleotides between position +11 and +30 (Caenorhabditis elegans)
REACT:R-DRE-8950757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Danio rerio)
REACT:R-DRE-418918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The UDP/CysLT (P2Y17) receptor can bind UTP (Danio rerio)
GO:0008474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-protein thiolesterase activity
GO:0008474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-(protein) hydrolase activity
GO:0008474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LYPLA2 hydrolyses PALM-C3,4-GAP43 (Homo sapiens)
GO:0008474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-protein hydrolase activity
GO:0008474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-protein thioesterase activity
GO:0008474	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	palmitoyl-[protein] hydrolase
REACT:R-XTR-73806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AIR + CO2 => CAIR (Xenopus tropicalis)
RHEA:15459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + H(+) + NADH => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)
RHEA:30598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylacetate + FADH2 + O2 <=> 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O
RHEA:49120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + protoviolaceinate = H2O + NADP(+) + violaceinate
REACT:R-HSA-158354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Homo sapiens)
REACT:R-DDI-194641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
REACT:R-CEL-3928631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GIT1 binds bPIX (Caenorhabditis elegans)
RHEA:45708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydrocarnitine + acetyl-CoA = 3-dehydrocarnityl-CoA + acetate
REACT:R-HSA-8984994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds MAF (Homo sapiens)
REACT:R-CEL-8954327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCKL1 phosphorylates urindine, cytidine (Caenorhabditis elegans)
RHEA:70711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-alanine(in) = D-alanine(out)
RHEA:60343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine
REACT:R-DME-9018804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 GEFs activate RAC3 (Drosophila melanogaster)
REACT:R-CEL-977317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Caenorhabditis elegans)
REACT:R-CFA-9693198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the plasma membrane (Canis familiaris)
REACT:R-MMU-1614645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Mus musculus)
REACT:R-HSA-1592278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of proMMP2 (Homo sapiens)
RHEA:43345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-HSA-2769015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 PEST domain mutants translocate from cytosol to nucleus (Homo sapiens)
REACT:R-HSA-9007447	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 forms the PRC1L4 complex (Homo sapiens)
RHEA:35677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxohexadecasphinganine + CO2 + CoA => H(+) + L-serine + tetradecanoyl-CoA
REACT:R-MMU-5618093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis by HSP90 (Mus musculus)
RHEA:45782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol
REACT:R-DME-8847968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN binds FRK (Drosophila melanogaster)
REACT:R-BTA-893616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + pyruvate => 2-oxoglutaramate + alanine (Bos taurus)
REACT:R-CFA-5690856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)
REACT:R-CFA-9667914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALK binds ligand midkine (MDK) (Canis familiaris)
REACT:R-SSC-8987255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Sus scrofa)
RHEA:67618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GMP + diphosphate + H(+) => 8-oxo-GTP + H2O
REACT:R-CFA-191101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Canis familiaris)
REACT:R-BTA-2028591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Bos taurus)
REACT:R-HSA-9684018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)
RHEA:14072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH
RHEA:67375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-seryl-L-threonine <=> L-serine + L-threonine
RHEA:72420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-coumarate + ATP + H(+) => (E)-4-coumaroyl-AMP + diphosphate
REACT:R-DRE-5623525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo-carrying vesicles bud from the TGN (Danio rerio)
REACT:R-SCE-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Saccharomyces cerevisiae)
RHEA:65484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexan-1-ol + hexanoyl-CoA = CoA + hexyl hexanoate
GO:0051786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol 13,14-reductase activity
GO:0051786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity
GO:0051786	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	retinol saturase activity
GO:0051786	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RetSat activity
GO:0051786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity
GO:0051786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13,14)-all-trans-retinol saturase activity
REACT:R-MMU-419351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAF receptor binds platelet activating factor (Mus musculus)
REACT:R-CFA-2187388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Canis familiaris)
REACT:R-DRE-9604328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 phosphorylates NOTCH4 (Danio rerio)
REACT:R-SPO-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Schizosaccharomyces pombe)
REACT:R-SSC-2197646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1 (SR-BI, CLA-1) binds ligands (Sus scrofa)
RHEA:15519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-sulfo-D-glucosamine + sulfate => H2O + N(2),6-disulfo-D-glucosamine
RHEA:43596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde
REACT:R-DRE-8981622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myoglobin:oxygen dissociates (Danio rerio)
REACT:R-DME-9012349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)
RHEA:29715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate + FMNH2 + O2 = FMN + glycolaldehyde + 2 H(+) + H2O + sulfite
REACT:R-RNO-444416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Rattus norvegicus)
RHEA:37852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-deoxydaunorubicin + H(+) + NADPH + O2 => 13-dihydrodaunorubicin + H2O + NADP(+)
RHEA:33206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
RHEA:61694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + L-threonyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP
REACT:R-HSA-1912366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR206 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)
RHEA:66713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate
REACT:R-RNO-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Rattus norvegicus)
RHEA:47037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine in 5S rRNA => pseudouridine in 5S rRNA
REACT:R-DRE-5340130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Danio rerio)
REACT:R-BTA-140216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PMAIP1 (NOXA) to mitochondria (Bos taurus)
REACT:R-HSA-9710959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 dimer binds KPNA1 (Homo sapiens)
RHEA:36067	skos:prefLabel	"cobalt-precorrin-6B (C(15))-methyltransferase [decarboxylating]"
RHEA:36067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cobalt-precorrin-6B (C(15))-methyltransferase [decarboxylating]"
RHEA:36067	skos:altLabel	"cobalt-precorrin-6Y (C(15))-methyltransferase [decarboxylating]"
RHEA:36067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine
GO:0071771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehyde decarbonylase activity
GO:0071771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decarbonylase activity
RHEA:14466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-histidinol phosphate => L-histidinol + phosphate
RHEA:60514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine => a guanosine in miRNA + S-adenosyl-L-methionine
REACT:R-DRE-8950387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX binds EBI3 (Danio rerio)
RHEA:72635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxy-1-methoxyphenazine N(5)-oxide + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine
REACT:R-SSC-9686920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PELI1 ubiquitinates RIPK3 at K363 (Sus scrofa)
REACT:R-SSC-174660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Sus scrofa)
RHEA:11078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + CO2 + NAD(+) + NH4(+) => anthranilate + 3 H(+) + NADH + O2
RHEA:42347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + p-cumate <=> (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)
RHEA:53995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate
RHEA:43620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine + NADP(+) = aminoacetaldehyde + CO2 + NADPH
RHEA:43620	skos:prefLabel	"serine 3-dehydrogenase (NADP(+))"
RHEA:43620	skos:altLabel	"serine 3-dehydrogenase"
RHEA:43620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"serine 3-dehydrogenase (NADP(+))"
GO:0050603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiophene-2-carboxyl-CoA hydroxylase activity
GO:0050603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiophene-2-carbonyl-CoA monooxygenase activity
GO:0050603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiophene-2-carboxyl-CoA dehydrogenase activity
GO:0050603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiophene-2-carboxyl-CoA monooxygenase activity
GO:0050603	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity
GO:0008513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secondary active organic cation transmembrane transporter activity
GO:0008513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Homo sapiens)
GO:0008513	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	polyspecific organic cation transmembrane transporter activity
GO:0008513	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	organic cation porter activity
RHEA:50262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate => 11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione
REACT:R-HSA-964830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)
RHEA:52400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-phospho-D-threonate + NAD(+) = 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH
RHEA:34712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acid
REACT:R-SSC-5358592	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA ligase I ligates single stranded nick in double stranded DNA (Sus scrofa)
REACT:R-RNO-2018659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Rattus norvegicus)
GO:0047782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coniferin beta-D-glucosidase activity
GO:0047782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coniferin beta-glucosidase activity
GO:0047782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coniferin b-glucosidase activity
GO:0047782	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	coniferin-hydrolyzing beta-glucosidase activity
REACT:R-SSC-183126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to surface-associated C3b (Sus scrofa)
RHEA:53185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine
REACT:R-CFA-2161899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)
REACT:R-SSC-9748979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Sus scrofa)
RHEA:17738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + shikimate => 3-dehydroshikimate + H(+) + NADPH
REACT:R-SSC-2129353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tropoelastin associates with microfibrils (Sus scrofa)
EC:3.4.11.22	skos:altLabel	"vacuolar aminopeptidase I"
EC:3.4.11.22	skos:prefLabel	"aminopeptidase I"
EC:3.4.11.22	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminopeptidase I"
EC:3.4.11.22	skos:altLabel	"aminopeptidase yscI"
EC:3.4.11.22	skos:altLabel	"aminopeptidase III"
EC:3.4.11.22	skos:altLabel	"leucine aminopeptidase IV"
REACT:R-CFA-9625487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2 autophosphorylates downstream of EGFR (Canis familiaris)
REACT:R-XTR-4086036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate NRIP1 with SUMO1 (Xenopus tropicalis)
RHEA:43208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (carboxymethyluridine(34)-5-O)-methyltransferase"
RHEA:43208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine
RHEA:43208	skos:altLabel	"tRNA methyltransferase 9"
RHEA:43208	skos:prefLabel	"tRNA (carboxymethyluridine(34)-5-O)-methyltransferase"
REACT:R-GGA-9008696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37(?-218) translocates from the cytosol to the nucleus (Gallus gallus)
RHEA:15666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucose + L-lysyl-[protein] => H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]
REACT:R-RNO-5654413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
RHEA:38175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
REACT:R-CFA-191114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of branched starch (amylopectin) by extracellular amylase (Canis familiaris)
REACT:R-SSC-9646468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mTORC1 binds RHEB:GTP (Sus scrofa)
RHEA:44826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol
RHEA:36219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-MMU-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Mus musculus)
REACT:R-DME-1358791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of USP8 by P-AKT (Drosophila melanogaster)
RHEA:66893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:49939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:35938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + L-proline + L-tryptophan <=> 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)
REACT:R-DDI-6784729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Dictyostelium discoideum)
RHEA:48166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + red chlorophyll catabolite => epoxypheophorbide a + H2O
RHEA:39648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)
REACT:R-BTA-6781840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERCC6 binds stalled RNA Pol II (Bos taurus)
RHEA:21650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + CO2 + H2O => H(+) + prephenate
GO:0052773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose deacetylase (nonreducing end)
GO:0052773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetylchitobiose deacetylase activity
RHEA:15422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate
REACT:R-HSA-74059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Homo sapiens)
GO:0032397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activating MHC class I receptor activity
REACT:R-MMU-8850356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCR binds microbial lipid-based antigen via CD1 (Mus musculus)
GO:0018460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexanol dehydrogenase activity
GO:0018460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cyclohexanol:NAD+ oxidoreductase activity
REACT:R-SSC-6786652	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHIT1 hydrolyses CHIT to 3xADGP (Sus scrofa)
REACT:R-CEL-109341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Caenorhabditis elegans)
REACT:R-SSC-8854612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 accelerates GTP hydrolysis by RAB33B (Sus scrofa)
REACT:R-SSC-2995330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COX10 transforms heme to heme O (Sus scrofa)
EC:6.5.1.1	skos:prefLabel	"DNA ligase (ATP)"
EC:6.5.1.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"DNA ligase (ATP)"
EC:6.5.1.1	skos:altLabel	"polydeoxyribonucleotide synthase (ATP)"
EC:6.5.1.1	skos:altLabel	"sealase"
EC:6.5.1.1	skos:altLabel	"DNA repair enzyme"
EC:6.5.1.1	skos:altLabel	"polynucleotide ligase (ATP)"
EC:6.5.1.1	skos:altLabel	"DNA joinase"
REACT:R-DDI-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Dictyostelium discoideum)
REACT:R-RNO-75849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Citrate from Mitochondrial Matrix to cytosol (Rattus norvegicus)
RHEA:17539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine + NH4(+) => (R)-carnitinamide + H2O
RHEA:51063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androst-1-ene-3,17-dione + A <=> AH2 + androsta-1,4-diene-3,17-dione
RHEA:70829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-lysine(in) => L-arginine(in) + L-lysine(out)
RHEA:60282	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine
RHEA:29096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+)(in) + NADH + ubiquinone-8 => 4 H(+)(out) + NAD(+) + ubiquinol-8
RHEA:17392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-arabinitol + NAD(+) <=> D-ribulose + H(+) + NADH
REACT:R-BTA-2316434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
RHEA:29439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)
RHEA:35662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose <=> GDP + H(+) + mannosylinositol phosphorylphytoceramide
RHEA:12099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-benzylformamide <=> benzylamine + formate
RHEA:32532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate => alpha-D-mannose 1-phosphate + D-glucose
REACT:R-CFA-73567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Canis familiaris)
EC:3.2.1.193	skos:prefLabel	"ginsenosidase type I"
EC:3.2.1.193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ginsenosidase type I"
REACT:R-MMU-5624492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK phosphorylates p21 RAF1 on S338 (Mus musculus)
REACT:R-DME-5693724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESD dimer hydrolyses S-FGSH to GSH (Drosophila melanogaster)
REACT:R-BTA-177943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2:SOS1 complex binds to EGF:EGFR complex (Bos taurus)
RHEA:41277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eicosanoate + sphing-4-enine => H2O + N-eicosanoyl-sphing-4-enine
REACT:R-MMU-72621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ribosomal scanning  (Mus musculus)
RHEA:34916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose(in) => D-galactose(out)
GO:0044377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II proximal promoter region sequence-specific DNA binding, bending
GO:0044377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending
GO:0044377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II proximal promoter sequence-specific DNA binding, bending
GO:0044377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II promoter proximal region sequence-specific DNA binding, bending
GO:0044377	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
RHEA:41721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)
RHEA:20853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+)(in) + H2O => ADP + 2 H(+)(out) + phosphate
REACT:R-HSA-1791108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of SULT1A3 (Homo sapiens)
REACT:R-DME-201717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK2-mediated phosphorylation of DVL (Drosophila melanogaster)
RHEA:58229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-asparaginyl-[protein] + NAD(+) => H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide
RHEA:18658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + NADP(+) => 3-hydroxypyruvate + H(+) + NADPH
REACT:R-GGA-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Gallus gallus)
RHEA:19471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2
GO:0140586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	promoter-terminator loop anchoring activity
GO:0140586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terminator-promoter loop anchoring activity
REACT:R-CFA-265010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)
REACT:R-SSC-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Sus scrofa)
REACT:R-XTR-5138459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A:FZD4 is endocytosed (Xenopus tropicalis)
RHEA:58710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	rifampicin para-naphthoquinone carboxamide => rifampicin ortho-naphthoquinone carboxamide
REACT:R-CFA-6810594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Canis familiaris)
REACT:R-GGA-9013158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 GDIs block activation of CDC42 (Gallus gallus)
REACT:R-CFA-4641147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DACT1 binds DVL2 (Canis familiaris)
GO:0050465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH
GO:0050465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitroquinoline-N-oxide reductase"
GO:0050465	skos:altLabel	"4NQO reductase"
GO:0050465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitroquinoline-N-oxide reductase activity
GO:0050465	skos:altLabel	"4-nitroquinoline 1-oxide reductase"
GO:0050465	skos:altLabel	"NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase"
GO:0050465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity
GO:0050465	skos:prefLabel	"nitroquinoline-N-oxide reductase"
GO:0050465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity
GO:0050465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-nitroquinoline 1-oxide reductase activity
GO:0050465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4NQO reductase activity
GO:0050465	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity
GO:0050465	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH
RHEA:61793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tryptophan => diphosphate + L-tryptophyl-5'-AMP
RHEA:42849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyltetracenomycin C + dTDP-beta-L-rhamnose => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)
REACT:R-HSA-6799416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 stimulates expression of TP53INP1 (Homo sapiens)
REACT:R-DME-2744349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTYH1 transports cytosolic Cl- to extracellular region (Drosophila melanogaster)
RHEA:56065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP
REACT:R-DDI-432054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water out of cell (Dictyostelium discoideum)
RHEA:28496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + dimethyl sulfoxide => a menaquinone + dimethyl sulfide + H2O
REACT:R-CFA-187959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Canis familiaris)
REACT:R-MMU-5653766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)
REACT:R-HSA-2243938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant is phosphorylated by TORC2 complex (Homo sapiens)
REACT:R-DRE-190429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1c (Danio rerio)
RHEA:46064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-MMU-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Mus musculus)
GO:0005242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kir channel activity
GO:0005242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inward rectifier potassium channel activity
GO:0019900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kinase binding
REACT:R-SSC-5635856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Sus scrofa)
REACT:R-XTR-3149563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Xenopus tropicalis)
RHEA:30980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + all-trans-lycopene => AH2 + all-trans-3,4-didehydrolycopene
REACT:R-BTA-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Bos taurus)
REACT:R-DRE-392054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Danio rerio)
REACT:R-GGA-2534378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hv1 Mediated H+ Permeability (Gallus gallus)
REACT:R-BTA-374298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid receptors bind opioid peptides (Bos taurus)
RHEA:54925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]
REACT:R-GGA-5654631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3 phosphorylates PPTN11 (Gallus gallus)
REACT:R-DME-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Drosophila melanogaster)
REACT:R-DDI-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Dictyostelium discoideum)
REACT:R-CFA-5695957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Canis familiaris)
REACT:R-DDI-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Dictyostelium discoideum)
REACT:R-GGA-9013023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB GEFs activate RHOB (Gallus gallus)
RHEA:44682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP
RHEA:67277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanal + NAD(+) => 2 H(+) + hexanoate + NADH
RHEA:67829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine => a lipid A disaccharide + H(+) + UDP
REACT:R-SSC-9706319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to SLA (Sus scrofa)
REACT:R-BTA-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Bos taurus)
REACT:R-MMU-4551648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TDG with SUMO1 (Mus musculus)
REACT:R-HSA-446089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BP180 interacts extracellularly with Laminin 332 (Homo sapiens)
GO:0090585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity
RHEA:44815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-11 + CO2 + diphosphate
REACT:R-BTA-8853753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Bos taurus)
EC:3.4.21.96	skos:altLabel	"lactococcal cell envelope-associated proteinase"
EC:3.4.21.96	skos:prefLabel	"lactocepin"
EC:3.4.21.96	skos:altLabel	"wall-associated serine proteinase"
EC:3.4.21.96	skos:altLabel	"extracellular lactococcal proteinase"
EC:3.4.21.96	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lactocepin"
REACT:R-CFA-5675376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
RHEA:35433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3,7-di-O-beta-D-glucoside + vanillate => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside
RHEA:60091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADPH
REACT:R-XTR-8857549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HBEGF-bound EGFR forms a heterodimer with GPNMB (Xenopus tropicalis)
RHEA:49910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-carnitine(in) + O-acetyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acetyl-(R)-carnitine(in)
RHEA:25273	skos:prefLabel	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase"
RHEA:25273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate
RHEA:25273	skos:altLabel	"D-lysine-adding enzyme"
RHEA:25273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase"
RHEA:25273	skos:altLabel	"UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase"
REACT:R-SPO-1482847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)
REACT:R-CFA-5610722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK1 phosphorylates p-GLI3 (Canis familiaris)
GO:0009040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate + NADP(+) = H(+) + N-carbamoyl-2-oxoglycine + NADPH
GO:0009040	skos:prefLabel	"ureidoglycolate dehydrogenase"
GO:0009040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ureidoglycolate dehydrogenase activity
GO:0009040	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity
GO:0009040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ureidoglycolate dehydrogenase"
REACT:R-DME-2025890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcineurin binds NFATC1,2,3 (Drosophila melanogaster)
REACT:R-DME-8865275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-BB clevage by Furin (Drosophila melanogaster)
RHEA:16706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + NADP(+) => estrone + H(+) + NADPH
RHEA:72803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + N(omega)-methyl-L-arginine(in) = L-arginine(in) + N(omega)-methyl-L-arginine(out)
REACT:R-BTA-9629195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Bos taurus)
REACT:R-CFA-508162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Canis familiaris)
REACT:R-HSA-880053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] (Homo sapiens)
RHEA:20197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"heparosan-N-sulfate-glucuronate 5-epimerase"
RHEA:20197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)
RHEA:20197	skos:prefLabel	"heparosan-N-sulfate-glucuronate 5-epimerase"
RHEA:59796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]
REACT:R-CEL-8863727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STON2 is neddylated (Caenorhabditis elegans)
RHEA:47982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose
RHEA:34904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 glutathione + 2 H(+) + selenite => glutathione disulfide + 3 H2O + selenodiglutathione
REACT:R-RNO-8847968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTEN binds FRK (Rattus norvegicus)
RHEA:25677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
REACT:R-BTA-450517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Bos taurus)
RHEA:41477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + zymosterol => CoA + zymosterol ester
RHEA:22768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one
RHEA:22768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-ketovalidoxylamine C-N-lyase"
RHEA:22768	skos:prefLabel	"3-ketovalidoxylamine C-N-lyase"
RHEA:29979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine(in) + H(+)(in) = 2'-deoxyadenosine(out) + H(+)(out)
RHEA:67941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyoctanoate + O2 => 2-oxooctanoate + H2O2
REACT:R-CFA-5685608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC2B binds KLRF1 dimer (Canis familiaris)
REACT:R-DME-5682026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN bound to shortened telomeres activates ATM (Drosophila melanogaster)
RHEA:70979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)
RHEA:70146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SPO-5665868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMPK (complex) phosphorylates ULK1 (complex) (Schizosaccharomyces pombe)
REACT:R-GGA-6807872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer (Gallus gallus)
RHEA:68417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-(homo)2aconitate + H2O => (2R,3S)-iso(homo)2citrate
RHEA:59873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP
REACT:R-CFA-5696482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTF1 binds LIFR:JAKs (Canis familiaris)
REACT:R-CEL-561253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A12 exchanges extracellular urate for cytosolic LACT (Caenorhabditis elegans)
REACT:R-CFA-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Canis familiaris)
RHEA:36996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA
GO:0090612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP deaminase activity
GO:0090612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic adenosine monophosphate deaminase activity
REACT:R-HSA-9020251	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Homo sapiens)
REACT:R-BTA-2161614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Bos taurus)
RHEA:15313	skos:prefLabel	"ethanolamine ammonia-lyase"
RHEA:15313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethanolamine = acetaldehyde + NH4(+)
RHEA:15313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ethanolamine ammonia-lyase"
RHEA:51116	skos:altLabel	"methyltransferase Trm14"
RHEA:51116	skos:prefLabel	"tRNA (guanine(6)-N(2))-methyltransferase"
RHEA:51116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (guanine(6)-N(2))-methyltransferase"
RHEA:51116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(6) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine
RHEA:51116	skos:altLabel	"m(2)G6 methyltransferase"
RHEA:56335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-triphosphoadenylyl-(2'->5')-adenosine + H2O <=> AMP + ATP + H(+)
REACT:R-CFA-71849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LDH tetramer reduces PYR to LACT (Canis familiaris)
GO:0052907	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	M(6)A(1618) activity
GO:0052907	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	rRNA large subunit methyltransferase F activity
GO:0052907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	23S rRNA (adenine(1618)-N(6))-methyltransferase activity
REACT:R-PFA-9755015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1 transports RBV from extracellular region to cytosol (Plasmodium falciparum)
RHEA:39675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA
RHEA:68120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA
REACT:R-GGA-372388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fructose 1,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)
EC:3.4.24.43	skos:prefLabel	"atroxase"
EC:3.4.24.43	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"atroxase"
REACT:R-DRE-5635839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3:SUFU dissociates (Danio rerio)
RHEA:52884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-phenylhydroxylamine + 2 NADP(+) = 2 H(+) + 2 NADPH + nitrobenzene
RHEA:52884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrobenzene nitroreductase"
RHEA:52884	skos:prefLabel	"nitrobenzene nitroreductase"
GO:0005219	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	caffeine-sensitive calcium-release channel
GO:0005219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ryanodine-sensitive calcium-release channel activity
GO:0005219	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ryanodine receptor
GO:0005219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Homo sapiens)
REACT:R-GGA-9696267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds GTP (Gallus gallus)
RHEA:44402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + ubiquinol-6 => 3-demethylubiquinol-6 + S-adenosyl-L-methionine
GO:0004978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenocorticotropin receptor activity
GO:0004978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corticotropin receptor activity
GO:0004978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenocorticotropic hormone receptor activity
GO:0004978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACTH receptor activity
REACT:R-XTR-5691001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Xenopus tropicalis)
RHEA:38850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-CFA-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Canis familiaris)
RHEA:64825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-naphthaleneacetamide + H2O => 1-naphthaleneacetate + NH4(+)
RHEA:35329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxodocosanoyl-CoA + CO2 + CoA => eicosanoyl-CoA + H(+) + malonyl-CoA
GO:0106326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
REACT:R-CFA-5693580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD52 with the RPA complex at resected DNA DSBs (Canis familiaris)
RHEA:37748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine => 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
RHEA:12746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,4-lactone + H2O => a 4-hydroxyacid + H(+)
RHEA:39293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA
REACT:R-CFA-2533950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibronectin degradation by MMP14, TMPRSS6 (Canis familiaris)
RHEA:62604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate
REACT:R-DRE-5444516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH6 Complex (Danio rerio)
REACT:R-SSC-444008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)
REACT:R-HSA-8849826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST14 hydrolyzes and activates KLK5 (Homo sapiens)
REACT:R-MMU-4167509	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial BTD hydrolyses BCTN (Mus musculus)
REACT:R-PFA-5681980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 binds ATG7 dimer (Plasmodium falciparum)
RHEA:33888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-secoisolariciresinol + 2 NAD(+) => (-)-matairesinol + 2 H(+) + 2 NADH
REACT:R-CEL-203977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAR1 Activation And Membrane Binding (Caenorhabditis elegans)
REACT:R-DRE-77591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Danio rerio)
REACT:R-DRE-5362564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADH1A,1C,4 oxidise atROL to atRAL in vitro (Danio rerio)
REACT:R-RNO-69227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Rattus norvegicus)
REACT:R-HSA-2187266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARA5 binds ligands (Homo sapiens)
GO:0034986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iron chaperone activity
RHEA:63888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine
REACT:R-CFA-997237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2B proteins bind JAK2 (Canis familiaris)
REACT:R-CFA-174456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Joining of adjacent Okazaki fragments of the C-strand (Canis familiaris)
REACT:R-SSC-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Sus scrofa)
RHEA:15802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
REACT:R-HSA-8852351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 promotes translocation of TP53 to the cytosol (Homo sapiens)
EC:1.1.1.299	skos:prefLabel	"malate dehydrogenase [NAD(P)(+)]"
EC:1.1.1.299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"malate dehydrogenase [NAD(P)(+)]"
REACT:R-DME-5654511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFRL1 dimer binds FGFs (Drosophila melanogaster)
REACT:R-HSA-5696960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP49 deubiquitinates H2B (Homo sapiens)
REACT:R-MMU-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Mus musculus)
RHEA:59851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)
GO:0019810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine binding
REACT:R-XTR-8959798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC30A10 transports Mn2+ from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-SPO-446202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the first glucose to the N-glycan precursor by ALG6 (Schizosaccharomyces pombe)
REACT:R-XTR-9027321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Xenopus tropicalis)
REACT:R-CFA-5689111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 autoubiquitinates (Canis familiaris)
REACT:R-RNO-4420128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC-1 phosphorylates SHB (Rattus norvegicus)
EC:2.4.1.146	skos:prefLabel	"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase"
EC:2.4.1.146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase"
EC:2.4.1.146	skos:altLabel	"elongation 3beta-GalNAc-transferase"
EC:2.4.1.146	skos:altLabel	"O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II"
REACT:R-XTR-1296024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in neuroendocrine cells (Xenopus tropicalis)
RHEA:55547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine
RHEA:60612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octanoyl-sn-glycero-3-phosphocholine = 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline
REACT:R-DME-195275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of APC component of the destruction complex (Drosophila melanogaster)
RHEA:22847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:66184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic AMP(in) + ATP + H2O = 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate
REACT:R-SPO-83723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Schizosaccharomyces pombe)
RHEA:52663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-alpha-amino acid + ATP + holo-[ACP] <=> AMP + an L-alpha-aminoacyl-[ACP] + diphosphate
RHEA:23749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP => diphosphate + pppGp(2'-5')A
RHEA:46748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxyphosphate + NH4(+) = carbamate + 2 H(+) + phosphate
REACT:R-SSC-3785768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds DNA double strand breaks (Sus scrofa)
RHEA:37400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-MMU-975593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Mus musculus)
REACT:R-GGA-111881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Gallus gallus)
RHEA:25336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-cysteine + tRNA(Cys) => H2O + L-cysteinyl-tRNA(Cys)
RHEA:62205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal
RHEA:63523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopropylphenol + H(+) + NADH + O2 <=> 3-isopropylcatechol + H2O + NAD(+)
REACT:R-DRE-199299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates FOXO transcription factors (Danio rerio)
RHEA:42820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetracenomycin A2 monooxygenase-diooxygenase"
RHEA:42820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 = H2O + 2 NADP(+) + tetracenomycin C
RHEA:42820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 = H2O + 2 NAD(+) + tetracenomycin C
RHEA:42820	skos:prefLabel	"tetracenomycin A2 monooxygenase-diooxygenase"
RHEA:25487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate <=> (1S,4R)-camphene + diphosphate
REACT:R-MMU-9668405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Mus musculus)
RHEA:61022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine => acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA
REACT:R-MMU-5627775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1,2,3 (Mus musculus)
REACT:R-SSC-873922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STAT1 by JAK kinases (Sus scrofa)
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoglycoside 3-N-acetyltransferase activity
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	gentamycin acetyltransferase I
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-N-aminoglycoside acetyltransferase activity
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoglycoside acetyltransferase AAC(3)-1
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gentamycin 3'-N-acetyltransferase activity
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentamicin 3'-N-acetyltransferase activity
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-aminoglycoside acetyltransferase activity
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	acetyl-CoA:gentamicin-C N3'-acetyltransferase activity
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentamicin-(3)-N-acetyltransferase activity
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gentamicin acetyltransferase I activity
GO:0046353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminoglycoside acetyltransferase AAC(3)-I activity
REACT:R-RNO-5661217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds zinc (Rattus norvegicus)
RHEA:33695	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C20 sphinganine + NADP(+) = 3-oxoeicosasphinganine + H(+) + NADPH
REACT:R-XTR-8850560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha releases G-protein heterotrimer from PDCL  (Xenopus tropicalis)
RHEA:51660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 = an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)
REACT:R-CFA-1236954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides by IRAP in endocytic vesicles (Canis familiaris)
REACT:R-MMU-9748957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)
RHEA:70194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NAD(+) <=> 3'-NADP(+) + ADP + H(+)
REACT:R-PFA-5694527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of SAR1B GTPase (Plasmodium falciparum)
REACT:R-XTR-2161940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Xenopus tropicalis)
REACT:R-XTR-446634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 is activated by autophosphorylation (Xenopus tropicalis)
REACT:R-GGA-434003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPS binding to CD14 co-receptor (Gallus gallus)
REACT:R-PFA-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Plasmodium falciparum)
REACT:R-CFA-8964634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Canis familiaris)
RHEA:16469	skos:prefLabel	"succinyl-CoA:(R)-benzylsuccinate CoA-transferase"
RHEA:16469	skos:altLabel	"benzylsuccinate CoA-transferase"
RHEA:16469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinyl-CoA:(R)-benzylsuccinate CoA-transferase"
RHEA:16469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate
REACT:R-BTA-1971483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Bos taurus)
REACT:R-HSA-6814554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
RHEA:56249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]
RHEA:16065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate
RHEA:16065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phytanoyl-CoA dioxygenase"
RHEA:16065	skos:altLabel	"phytanoyl-CoA 2-hydroxylase"
RHEA:16065	skos:altLabel	"phytanoyl-CoA hydroxylase"
RHEA:16065	skos:altLabel	"phytanoyl-CoA 2 oxoglutarate dioxygenase"
RHEA:16065	skos:prefLabel	"phytanoyl-CoA dioxygenase"
RHEA:16065	skos:altLabel	"phytanoyl-CoA alpha-hydroxylase"
REACT:R-DME-5696600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Drosophila melanogaster)
REACT:R-DRE-174425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Danio rerio)
GO:0018685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkane 1-monooxygenase activity
GO:0018685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkane 1-hydroxylase activity
GO:0018685	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkane hydroxylase activity
GO:0018685	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkane monooxygenase activity
GO:0018685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid (omega-1)-hydroxylase activity
GO:0018685	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	fatty acid omega-hydroxylase activity
GO:0018685	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity
GO:0018685	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	lauric acid omega-hydroxylase activity
GO:0018685	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-hydroxylase activity
GO:0018685	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	omega-hydroxylase activity
GO:0033771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity
GO:0033771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	licodione synthase activity
GO:0033771	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2S)-flavanone 2-hydroxylase activity
REACT:R-GGA-5678261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Gallus gallus)
REACT:R-RNO-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Rattus norvegicus)
REACT:R-XTR-5422942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RXRA:PPARD binds FABP5:atRA (Xenopus tropicalis)
REACT:R-DDI-2684901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANOs transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)
REACT:R-GGA-388829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 phosphatase binds CTLA-4 (Gallus gallus)
REACT:R-SSC-2076392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfers GlcA to heparan (Sus scrofa)
RHEA:64763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-ethyl-L-cysteine <=> ethanethiol + NH4(+) + pyruvate
REACT:R-SSC-8950518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Sus scrofa)
REACT:R-DDI-156682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates NUDC (Dictyostelium discoideum)
REACT:R-HSA-9694334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNA1 is translated to pp1a (Homo sapiens)
REACT:R-HSA-1112604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated STATs are released (Homo sapiens)
REACT:R-HSA-1676161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane (Homo sapiens)
REACT:R-SSC-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)
REACT:R-HSA-909755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitochondrial uptake of (R)-3-aminoisobutyric acid (Homo sapiens)
RHEA:66971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
RHEA:65998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine => Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+)
GO:0036163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity
GO:0036456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine-(S)-S-oxide reductase activity
GO:0036456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + L-methionine (S)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine
REACT:R-DME-997326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Drosophila melanogaster)
REACT:R-SSC-9717841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-FDPS dimer binds NBPs (Sus scrofa)
RHEA:48426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O
RHEA:19540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol 1-phosphate + H2O <=> D-mannitol + phosphate
RHEA:60609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine
RHEA:26142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+) => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O
REACT:R-BTA-397891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs:G12/13 (active) dissociate (Bos taurus)
REACT:R-MMU-3323111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytoslic carboxylases translocate to mitochondrial matrix (Mus musculus)
REACT:R-CFA-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Canis familiaris)
REACT:R-DME-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)
REACT:R-XTR-389684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + alanine => glycine + pyruvate [peroxisome] (Xenopus tropicalis)
RHEA:64686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-alpha-D-glucose
RHEA:50942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe) => L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe)
REACT:R-CFA-453111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
REACT:R-CFA-9760082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 binds CREBBP,EP300 (Canis familiaris)
REACT:R-CEL-2029469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)
REACT:R-CFA-9668597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase:primase binds G-strand of the telomere (Canis familiaris)
REACT:R-SSC-5694018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Sus scrofa)
REACT:R-SSC-975119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Sus scrofa)
REACT:R-RNO-9624112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK4 (Rattus norvegicus)
REACT:R-SSC-70967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Sus scrofa)
RHEA:29106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5 H(+)(in) + menaquinone-8 + NADH <=> 4 H(+)(out) + menaquinol-8 + NAD(+)
RHEA:53801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholoyl-CoA + ursodeoxycholate => lithocholate + ursodeoxycholoyl-CoA
RHEA:52250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12 H(+) + 4 MnO2 => 6 H2O + 4 Mn(3+) + O2
RHEA:11402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4'-O-demethylsordarin + GDP + H(+) => GDP-6-deoxy-alpha-D-altrose + sordaricin
REACT:R-XTR-1980051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DLL4 binds NOTCH2 (Xenopus tropicalis)
REACT:R-XTR-1306953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Xenopus tropicalis)
REACT:R-RNO-9748963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TdGMP to 6TdGDP (Rattus norvegicus)
REACT:R-HSA-205238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 interacts with p-KIT (Homo sapiens)
REACT:R-GGA-3371503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Gallus gallus)
REACT:R-HSA-8954207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:ESR1 binds CXCL12 gene promoter (Homo sapiens)
REACT:R-CEL-3968362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of PIAS4 with SUMO1 (Caenorhabditis elegans)
RHEA:64368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2
EC:3.4.21.7	skos:prefLabel	"plasmin"
EC:3.4.21.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plasmin"
EC:3.4.21.7	skos:altLabel	"fibrinolysin"
EC:3.4.21.7	skos:altLabel	"fibrinase"
REACT:R-DME-430190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-SLP-76 binds NCK (Drosophila melanogaster)
RHEA:33398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester <=> GMP + N(alpha)-acetyl-L-lysine methyl ester
REACT:R-MMU-9018808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds effectors at the plasma membrane (Mus musculus)
REACT:R-XTR-5682385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The phagophore extends from the PIP3-enriched structure (Xenopus tropicalis)
RHEA:26478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate
REACT:R-CEL-201595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plakophilin-1 (Caenorhabditis elegans)
REACT:R-SSC-3134946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 ubiquitination by TRIM21 (Sus scrofa)
REACT:R-HSA-1461993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-HD5 is cleaved by trypsin (Homo sapiens)
RHEA:72137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine(in) => putrescine(out)
RHEA:30027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glyceraldehyde + H(+) + NADH = glycerol + NAD(+)
REACT:R-MMU-975608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRAT esterifies RBP2:atROL and FACYLs to atREs (Mus musculus)
RHEA:35348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O
REACT:R-DRE-2161745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-keto-3-deoxyoctonate cytidylyltransferase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-KDO synthetase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-3-deoxy-D-manno-octulosonate synthetase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-2-keto-3-deoxyoctulosonic acid synthetase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-deoxy-D-manno-octulosonate cytidylyltransferase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-deoxy-manno-octulosonate cytidylyltransferase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity
GO:0008690	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity
REACT:R-DRE-446200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLPP1 dephosphorylates DOLDP to DOLP (Danio rerio)
REACT:R-GGA-5362386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Hh (Gallus gallus)
RHEA:55132	skos:prefLabel	"D-alanine--[D-alanyl-carrier protein] ligase"
RHEA:55132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-alanine--[D-alanyl-carrier protein] ligase"
RHEA:55132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate
RHEA:12310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + L-2-aminoadipate + NADH => (S)-2-amino-6-oxohexanoate + H2O + NAD(+)
RHEA:11289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydromacarpine + H(+) + O2 => H2O2 + macarpine
RHEA:30072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + butanoate => acetate + butanoyl-CoA
REACT:R-HSA-6803875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds CDK1 and CCNB1 (Homo sapiens)
RHEA:72278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxalate(in) + sulfate(out) <=> oxalate(out) + sulfate(in)
REACT:R-MMU-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Mus musculus)
REACT:R-MMU-70785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Mus musculus)
REACT:R-BTA-8938951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds PAX5 (BSAP) (Bos taurus)
REACT:R-GGA-212432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DRIP coactivator complex (Gallus gallus)
REACT:R-MMU-2029452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of SYK to phosphorylated ITAMs (Mus musculus)
REACT:R-GGA-3465545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Gallus gallus)
RHEA:27394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)
RHEA:65476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-propanol + butanoyl-CoA = CoA + propyl butanoate
REACT:R-HSA-981539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3b binds to cell surface (Homo sapiens)
REACT:R-MMU-3239019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active p38 MAPK phosphorylates MAPKAPK5 (Mus musculus)
REACT:R-DRE-1254285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80:STAT5A complex translocates to the nucleus (Danio rerio)
RHEA:19745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thyroxine 5'-deiodinase"
RHEA:19745	skos:altLabel	"thyroxine 5-deiodinase"
RHEA:19745	skos:altLabel	"type II iodothyronine deiodinase"
RHEA:19745	skos:prefLabel	"thyroxine 5'-deiodinase"
RHEA:19745	skos:altLabel	"iodothyronine 5'-deiodinase"
RHEA:19745	skos:altLabel	"diiodothyronine 5'-deiodinase"
RHEA:19745	skos:altLabel	"L-thyroxine iodohydrolase (reducing)"
RHEA:19745	skos:altLabel	"iodothyronine outer ring monodeiodinase"
RHEA:19745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine
RHEA:19745	skos:altLabel	"type I iodothyronine deiodinase"
REACT:R-MMU-9708423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1:BACH1:Hemes are transported out of the nucleus (Mus musculus)
RHEA:55015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)
REACT:R-DME-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)
RHEA:46662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-pregnan-3,20-dione + NADP(+) => H(+) + NADPH + progesterone
REACT:R-SSC-9754130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 inhibitors bind CDK4 (Sus scrofa)
RHEA:52748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-isomaltosyl-(1->3)-isomaltose + H2O = 2 isomaltose
RHEA:17133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-seryl-[tyrosine-3-monooxygenase] = ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]
RHEA:17133	skos:prefLabel	"[tyrosine 3-monooxygenase] kinase"
RHEA:17133	skos:altLabel	"pheochromocytoma tyrosine hydroxylase-associated kinase"
RHEA:17133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[tyrosine 3-monooxygenase] kinase"
RHEA:17133	skos:altLabel	"tyrosine 3-monooxygenase kinase (phosphorylating)"
RHEA:45360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(11Z-eicosenoyl)-sphinganine = (11Z)-eicosenoate + sphinganine
REACT:R-SSC-204873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shp2 (Sus scrofa)
GO:0033740	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxylamine:acceptor oxidoreductase activity
GO:0033740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxylamine oxidoreductase activity
REACT:R-DRE-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
RHEA:16488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate <=> 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate
RHEA:52061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)
REACT:R-DDI-1483211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC:PITPNB is transported from the Golgi membrane to the ER membrane (Dictyostelium discoideum)
RHEA:42044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) = GDP + globoside Globo-H (d18:1(4E)) + H(+)
RHEA:67063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asnovolin I + S-adenosyl-L-methionine <=> asnovolin K + S-adenosyl-L-homocysteine
REACT:R-SCE-5623508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 stimulates nucleotide exchange on ARF4 (Saccharomyces cerevisiae)
REACT:R-HSA-5675470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIRC2/3 (cIAP1/2) is autoubiquitinated (Homo sapiens)
REACT:R-DME-1475028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Drosophila melanogaster)
REACT:R-CEL-5336453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NIPAs transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-DRE-6791109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GADD45A binds PCNA (Danio rerio)
RHEA:60280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(9) N-methyltransferase"
RHEA:60280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:60280	skos:prefLabel	"[histone H3]-lysine(9) N-methyltransferase"
REACT:R-HSA-9700120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTN and MDK bind to PTPRZ (Homo sapiens)
REACT:R-SPO-6807864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB1:GTP recruits GBF1 to the ERGIC (Schizosaccharomyces pombe)
REACT:R-HSA-909722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of p-STAT2:p-STAT1 dimer (Homo sapiens)
REACT:R-RNO-8948231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)
RHEA:67697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanedioyl-CoA => CoA + H(+) + hexadecanedioate
RHEA:20436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + xylitol <=> D-xylulose + H(+) + NADH
REACT:R-GGA-9627350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAC (DIABLO) binds XIAP (Gallus gallus)
RHEA:57291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O <=> a guanosine in RNA + H(+) + lactate
REACT:R-GGA-9796368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 binds STUB1 (Gallus gallus)
REACT:R-CFA-71401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Canis familiaris)
RHEA:25025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-methyl-5'-thioadenosine deaminase"
RHEA:25025	skos:altLabel	"MTA deaminase"
RHEA:25025	skos:prefLabel	"S-methyl-5'-thioadenosine deaminase"
RHEA:25025	skos:altLabel	"5-methylthioadenosine deaminase"
RHEA:25025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine
RHEA:18134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + sulfate => adenosine 5'-phosphosulfate + diphosphate
REACT:R-RNO-1562641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)
RHEA:40500	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine
RHEA:10772	skos:prefLabel	"6-phospho-beta-glucosidase"
RHEA:10772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O = D-glucose + D-glucose 6-phosphate
RHEA:10772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-phospho-beta-glucosidase"
RHEA:10772	skos:altLabel	"phosphocellobiase"
RHEA:10772	skos:altLabel	"phospho-beta-glucosidase"
RHEA:48752	skos:prefLabel	"validamycin A dioxygenase"
RHEA:48752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"validamycin A dioxygenase"
RHEA:48752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + validamycin A = CO2 + H(+) + succinate + validamycin B
REACT:R-DME-5221061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TDG excises 5-carboxylcytosine (Drosophila melanogaster)
REACT:R-BTA-2731074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Bos taurus)
RHEA:45615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine
RHEA:25879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + O2 <=> H2O2 + iminosuccinate
RHEA:42513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-acetamidopentanoate + H2O => 5-aminopentanoate + acetate
RHEA:30904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethylspheroidene + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + spheroidene
RHEA:56807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]
RHEA:57790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,3-dinitrobenzene + NADH + O2
REACT:R-DME-1535903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Drosophila melanogaster)
RHEA:31811	skos:altLabel	"TPS31"
RHEA:31811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + viridiflorene
RHEA:31811	skos:prefLabel	"viridiflorene synthase"
RHEA:31811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"viridiflorene synthase"
REACT:R-RNO-5617037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Rattus norvegicus)
REACT:R-DRE-1112510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6ST is tyrosine phosphorylated (Danio rerio)
RHEA:40398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)
REACT:R-RNO-5661230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT1A binds arsenic (Rattus norvegicus)
REACT:R-DRE-2426471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Danio rerio)
RHEA:55752	skos:prefLabel	"formate:CoB-CoM heterodisulfide,ferredoxin reductase"
RHEA:55752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formate:CoB-CoM heterodisulfide,ferredoxin reductase"
RHEA:55752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-HSA-9698923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of the major capsid protein (MCP) to the pPR-AP:pAP complex  (Homo sapiens)
REACT:R-XTR-983158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of peptides in ER (Xenopus tropicalis)
REACT:R-HSA-8938174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PF4 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)
REACT:R-XTR-9027302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Xenopus tropicalis)
REACT:R-MMU-71775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Mus musculus)
GO:0042970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homoserine transmembrane transporter activity
GO:0042970	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	homoserine transporter activity
REACT:R-GGA-6798745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of tertiary granule lumen proteins (Gallus gallus)
RHEA:61098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-3215406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 binds WDR77 (Homo sapiens)
RHEA:59647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylobiono-1,5-lactone + H2O <=> D-xylobionate + H(+)
REACT:R-DRE-2584246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT1-GTP hydrolyses its bound GTP to GDP (Danio rerio)
REACT:R-HSA-4549382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALG1 does not transfer the first Man to the N-glycan precursor (Homo sapiens)
RHEA:16923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-MMU-8951648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Mus musculus)
REACT:R-MMU-880033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Mus musculus)
REACT:R-SSC-9766687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SESN1,SESN1 bind SQSTM1 and KEAP1 (Sus scrofa)
REACT:R-CFA-994137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Canis familiaris)
RHEA:43360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + UDP-alpha-D-glucose = an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP
RHEA:72340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) => catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
RHEA:31367	skos:altLabel	"Nitrophorin 7"
RHEA:31367	skos:altLabel	"Prolixin S"
RHEA:31367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 3 nitrite = H2O + nitrate + 2 nitric oxide
RHEA:31367	skos:prefLabel	"nitrite dismutase"
RHEA:31367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"nitrite dismutase"
RHEA:57551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] <=> [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0016854	skos:prefLabel	"Racemases and epimerases"
GO:0016854	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	racemase and epimerase activity, acting on other compounds
GO:0016854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Racemases and epimerases"
GO:0016854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	racemase and epimerase activity
REACT:R-BTA-9009936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNASEL cleaves cellular ssRNA (Bos taurus)
REACT:R-HSA-9018894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Homo sapiens)
REACT:R-RNO-2545253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deacetylation of cohesin (Rattus norvegicus)
REACT:R-SSC-8950410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B:IL12B translocates from ER lumen to the extracellular region (Sus scrofa)
REACT:R-GGA-5357483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC1 binds PAK1-3 (Gallus gallus)
REACT:R-SSC-445079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by ERK (Sus scrofa)
GO:0032542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfiredoxin activity
GO:0032542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity
GO:0032542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphiredoxin activity
GO:0032542	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]
GO:0032542	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Srx1
RHEA:40766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Re + H2O <=> (20S)-ginsenoside Rg1 + L-rhamnopyranose
GO:0018675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-limonene 6-monooxygenase activity
GO:0018675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
GO:0018675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene 6-hydroxylase activity
GO:0018675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-limonene 6-hydroxylase activity
GO:0018675	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity
GO:0018675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-limonene 6-monooxygenase activity
RHEA:47229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-CEL-70349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)
REACT:R-XTR-164620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Xenopus tropicalis)
RHEA:56109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	genistein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-2454192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Allergen dependent IgE bound FCERI aggregation (Bos taurus)
RHEA:33949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-N-acetylparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine
RHEA:59441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-dehydrodiconiferyl alcohol + H(+) + NADPH => (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)
RHEA:58364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium-chain primary fatty alcohol + NADP(+) = a medium-chain fatty aldehyde + H(+) + NADPH
REACT:R-MMU-420975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca impermeable AMPA receptor ligand binding (Mus musculus)
RHEA:18791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactosamine 6-phosphate => D-glucosamine 6-phosphate
REACT:R-DRE-5692462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP13A1 transports Mn2+ from cytosol to ER lumen (Danio rerio)
REACT:R-MMU-8937814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 translocates to the nucleus (Mus musculus)
RHEA:56190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
GO:0030746	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoflavone O-methyltransferase activity
GO:0030746	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity
GO:0030746	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	isoflavone methyltransferase activity
GO:0030746	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4'-hydroxyisoflavone methyltransferase activity
GO:0030746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isoflavone 4'-O-methyltransferase activity
GO:0034546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4-dichloroaniline reductive dehalogenase activity
REACT:R-CFA-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Canis familiaris)
REACT:R-SSC-8868651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
RHEA:51118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine => guanosine(6) in tRNA + S-adenosyl-L-methionine
GO:0034914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,4,6-trinitrophenol hydride denitratase activity
GO:0034914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNP hydride denitratase activity
GO:0034914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trinitrophenol hydride denitratase activity
RHEA:15165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + sarcosine = glyoxylate + H2O2 + methylamine
RHEA:22357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + oxaloacetate => CO2 + phosphate + phosphoenolpyruvate
REACT:R-HSA-5621356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G (Homo sapiens)
GO:0015432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled bile acid transmembrane transporter activity
GO:0015432	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent bile acid transmembrane transporter activity
GO:0015432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type bile acid transporter activity
GO:0015432	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bile acid-exporting ATPase activity
GO:0015432	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	bile acid porter activity
REACT:R-HSA-8984023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)
REACT:R-DME-193535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)
RHEA:58097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetracosanoylglycerol + H2O => glycerol + H(+) + tetracosanoate
REACT:R-PFA-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Plasmodium falciparum)
RHEA:31990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> baruol
RHEA:36334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate
RHEA:26091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + limonene 1,2-epoxide + NAD(+) => (4S)-limonene + H(+) + NADH + O2
RHEA:31205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxooctanoyl-CoA + CoA => acetyl-CoA + hexanoyl-CoA
REACT:R-BTA-3296301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCRL2 binds CCL19 (Bos taurus)
REACT:R-HSA-9014293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 GDIs block activation of RAC2 (Homo sapiens)
RHEA:21292	skos:prefLabel	"phosphatidylinositol-4,5-bisphosphate 3-kinase"
RHEA:21292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)
RHEA:21292	skos:altLabel	"type I phosphoinositide 3-kinase"
RHEA:21292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol-4,5-bisphosphate 3-kinase"
RHEA:40909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-9653595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B binds BCL2L1 (Homo sapiens)
REACT:R-RNO-741386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIP2 induces K63-linked ubiquitination of NEMO (Rattus norvegicus)
RHEA:43043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-hexadecanoylhexadecasphinganine
REACT:R-BTA-5693612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex bound to DNA ends recruits ATM (Bos taurus)
REACT:R-MMU-3132737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKs phosphorylate ETS1 and ETS2 (Mus musculus)
REACT:R-SSC-8955285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Sus scrofa)
RHEA:30609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + all-trans-zeta-carotene => A + all-trans-phytofluene
REACT:R-SSC-8937792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds SRC (Sus scrofa)
REACT:R-HSA-180905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Vpr with ANT1 (Homo sapiens)
REACT:R-BTA-9705926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AR binds AR agonists (Bos taurus)
REACT:R-BTA-70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate <=> isocitrate (Bos taurus)
REACT:R-CFA-1678944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Canis familiaris)
REACT:R-MMU-5620921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Mus musculus)
REACT:R-SSC-6798373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates DYRK2 (Sus scrofa)
REACT:R-DRE-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Danio rerio)
REACT:R-MMU-5693536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates MDC1 (Mus musculus)
REACT:R-SCE-5678863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CFTR transports Cl- from cytosol to extracellular region (Saccharomyces cerevisiae)
REACT:R-XTR-426489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RISC binds inexactly matching target RNAs (Xenopus tropicalis)
RHEA:69382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-2-oxopentanoate + H2O2 => 2-hydroxy-4-methylpentanoate + O2
GO:0098600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH (Homo sapiens)
GO:0098600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	selenomethionine gamma-lyase activity
REACT:R-CFA-113412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pol II elongation complex moves on the template as transcript elongates (Canis familiaris)
RHEA:63219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-carbaguanosine(15) in tRNA + L-lysine <=> 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA
REACT:R-MMU-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Mus musculus)
RHEA:15169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-succinyl-L-glutamate = L-glutamate + succinate
RHEA:15169	skos:prefLabel	"succinylglutamate desuccinylase"
RHEA:15169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"succinylglutamate desuccinylase"
RHEA:15169	skos:altLabel	"SGDS"
RHEA:15169	skos:altLabel	"N(2)-succinylglutamate desuccinylase"
RHEA:65882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-1,3,17-trione + AH2 => 1-hydroxy-5alpha-androstan-3,17-dione + A
REACT:R-CFA-1433374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Processing of SCF isoform 1 (Canis familiaris)
RHEA:22586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(2+) + protoporphyrin IX => 2 H(+) + heme b
REACT:R-HSA-4641256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)
GO:0034938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyrrole-2-carboxylate monooxygenase activity
REACT:R-SSC-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Sus scrofa)
REACT:R-MMU-8869241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PITPNM1,2,3 exchange PI for PA (Mus musculus)
REACT:R-SSC-3769401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DKK and KRM bind LRP5/6 (Sus scrofa)
REACT:R-SSC-1006143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD46 binds C3b (Sus scrofa)
RHEA:58008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside F1 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg1 + H(+) + UDP
REACT:R-CEL-2404144	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Parenchymal atROL translocates to HSCs (Caenorhabditis elegans)
GO:0047019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(indol-3-yl)ethanol:NADP+ oxidoreductase activity
GO:0047019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
GO:0047019	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-3-ethanol:NADP+ oxidoreductase activity
GO:0047019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-acetaldehyde reductase (NADPH) activity
RHEA:53590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2
REACT:R-BTA-9731111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)
REACT:R-SSC-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Sus scrofa)
REACT:R-HSA-977605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H displaces Bb (Homo sapiens)
REACT:R-HSA-8950190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of PAK2 (Homo sapiens)
REACT:R-MMU-5654425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 binds SHC1 (Mus musculus)
EC:3.4.19.7	skos:altLabel	"(fMet)-releasing enzyme"
EC:3.4.19.7	skos:prefLabel	"N-formylmethionyl-peptidase"
EC:3.4.19.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-formylmethionyl-peptidase"
RHEA:40116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanoyl-CoA => CoA + H(+) + hexanoate
RHEA:48730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+)
REACT:R-CFA-217258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMO2:FAD:Mg2+ S-oxidises MTZ (Canis familiaris)
REACT:R-GGA-9701064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPV1 binds TRPV1 agonists (Gallus gallus)
REACT:R-SSC-428609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type I Na+-coupled phosphate co-transport (Sus scrofa)
GO:0036105	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PEX19-dependent mPTS binding
GO:0036105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	class 1 mPTS binding
GO:0036105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisome membrane class-1 targeting sequence binding
REACT:R-CEL-71850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Caenorhabditis elegans)
REACT:R-CFA-9796379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
RHEA:45780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
RHEA:57637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate => holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate
REACT:R-HSA-2046089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Homo sapiens)
REACT:R-RNO-429591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Rattus norvegicus)
REACT:R-CFA-5623643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH13 reduces atRAL to atROL (Canis familiaris)
REACT:R-DME-8949580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F1Fo ATP synthase dimerizes (Drosophila melanogaster)
EC:2.1.1.146	skos:prefLabel	"(iso)eugenol O-methyltransferase"
EC:2.1.1.146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(iso)eugenol O-methyltransferase"
RHEA:54611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]
REACT:R-SSC-8956050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Sus scrofa)
RHEA:47131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + deoxycholate <=> AMP + deoxycholoyl-CoA + diphosphate
RHEA:30515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"thermospermine synthase"
RHEA:30515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + thermospermine
RHEA:30515	skos:prefLabel	"thermospermine synthase"
RHEA:46150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside + H(+) + triphosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O
RHEA:60791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A24 + H(+) + O2 <=> CO2 + gibberellin A9 + H2O
REACT:R-HSA-1606324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment TBK1 to dsDNA:ZBP1 followed by its activation (Homo sapiens)
REACT:R-HSA-975170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
REACT:R-HSA-9725885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P4 bind PGR (in the HSP90 chaperone complex) (Homo sapiens)
REACT:R-HSA-9709878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BIL translocates to the nucleus (Homo sapiens)
REACT:R-SCE-992708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual-specific AKAPs bind type I and II PKA regulatory subunits (Saccharomyces cerevisiae)
RHEA:39921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(alk-1-enyl)-sn-glycerol + phosphate => 1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O
REACT:R-HSA-9621116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO1,FOXO3 bind CITED2 gene promoter (Homo sapiens)
REACT:R-SCE-1482539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)
REACT:R-DRE-166795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Classical C3 convertase (C4b:C2a complex) (Danio rerio)
REACT:R-DME-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)
RHEA:28435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] => ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]
REACT:R-DME-432148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fgr may phosphorylate p38 MAPK (Drosophila melanogaster)
REACT:R-GGA-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Gallus gallus)
REACT:R-GGA-517674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S158,221-HuR binds mRNA (Gallus gallus)
REACT:R-HSA-5692232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Homo sapiens)
REACT:R-BTA-191790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading and methylation of Sm proteins onto SMN Complexes (Bos taurus)
REACT:R-DRE-196086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Danio rerio)
REACT:R-XTR-2395302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hydroxylysino-5-ketonorleucine cross-links (Xenopus tropicalis)
RHEA:60181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-fructose(out) + H2O => ADP + D-fructose(in) + H(+) + phosphate
REACT:R-HSA-9615249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARBs bind AGRT1 (Homo sapiens)
RHEA:16794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantetheine + CO2
RHEA:30676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tetrahymanol => H2O + squalene
GO:0015315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	organophosphate:inorganic phosphate antiporter activity
REACT:R-BTA-189102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Bos taurus)
REACT:R-GGA-8875320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 GEFs exchange GTP for GDP on RAB5 (Gallus gallus)
REACT:R-DRE-351894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase mediated cleavage of BAP31 (Danio rerio)
REACT:R-XTR-5687123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S115 MAPKAPK5 translocates to the cytosol (Xenopus tropicalis)
RHEA:19550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + o-orsellinate depside => H(+) + 2 orsellinate
REACT:R-SPO-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Schizosaccharomyces pombe)
RHEA:42402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidyl-[protein] + lactose 6-phosphate(in) => lactose(out) + N(pros)-phospho-L-histidyl-[protein]
REACT:R-SSC-921155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT5 dissociates from the receptor complex (Sus scrofa)
RHEA:32609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6E)-8-hydroxygeranial + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)
REACT:R-BTA-193821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Bos taurus)
RHEA:53599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-sn-glycerol + phosphate
RHEA:63080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + ilicicolinate B = A + AMP + diphosphate + ilicicolin B
RHEA:12130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin] => 2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:38872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(2457) in 23S rRNA => pseudouridine(2457) in 23S rRNA
RHEA:58751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	desmethylnectriapyrone + S-adenosyl-L-methionine <=> H(+) + nectriapyrone + S-adenosyl-L-homocysteine
GO:0062101	skos:prefLabel	"peptide-aspartate beta-dioxygenase"
GO:0062101	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartylpeptide beta-dioxygenase activity
GO:0062101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidyl-aspartic acid 3-dioxygenase activity
GO:0062101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartyl-[protein] + O2 = 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate
GO:0062101	skos:altLabel	"aspartate beta-hydroxylase"
GO:0062101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"peptide-aspartate beta-dioxygenase"
GO:0062101	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartyl/asparaginyl beta-hydroxylase activity
GO:0062101	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
GO:0062101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide-aspartate beta-dioxygenase activity
GO:0062101	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartate beta-hydroxylase activity
GO:0062101	skos:altLabel	"aspartyl/asparaginyl beta-hydroxylase"
RHEA:52871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
RHEA:35200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S,S)-tartrate(out) => (S,S)-tartrate(in)
REACT:R-HSA-2160874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HYAL1 hydrolyses (HA)50 (Homo sapiens)
REACT:R-MMU-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Mus musculus)
RHEA:41650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + N(5)-phenyl-L-glutamine + phosphate => aniline + ATP + L-glutamate
RHEA:34737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphinganine + CoA + H(+) => a fatty acyl-CoA + sphinganine
RHEA:15517	skos:prefLabel	"disulfoglucosamine-6-sulfatase"
RHEA:15517	skos:altLabel	"N-sulfoglucosamine-6-sulfatase"
RHEA:15517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"disulfoglucosamine-6-sulfatase"
RHEA:15517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2),6-disulfo-D-glucosamine = H(+) + N-sulfo-D-glucosamine + sulfate
REACT:R-CFA-5649883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLB-mediated DNA strand displacement synthesis (Canis familiaris)
REACT:R-MMU-1169406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of host proteins (Mus musculus)
EC:2.4.99.13	skos:altLabel	"3-deoxy-D-manno-oct-2-ulosonic acid transferase"
EC:2.4.99.13	skos:altLabel	"Kdo transferase"
EC:2.4.99.13	skos:prefLabel	"(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase"
EC:2.4.99.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase"
EC:2.4.99.13	skos:altLabel	"3-deoxy-manno-octulosonic acid transferase"
RHEA:22063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-9024983	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Danio rerio)
RHEA:16043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->3)-beta-D-glucosyl](n) + phosphate
GO:0043800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexulose-6-phosphate isomerase activity
GO:0043800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUMPI
RHEA:71095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + pregnenolone sulfate(out) = 2 Na(+)(in) + pregnenolone sulfate(in)
REACT:R-DRE-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Danio rerio)
REACT:R-DRE-9766645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL3:RBX1 ubiquitinates KEAP1 (Danio rerio)
RHEA:31188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH
REACT:R-BTA-203700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS translocation from Golgi to Caveolae (Bos taurus)
REACT:R-GGA-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Gallus gallus)
RHEA:59176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + L-serine = AMP + H(+) + O-phospho-L-serine
RHEA:59176	skos:prefLabel	"L-serine kinase (ADP)"
RHEA:59176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-serine kinase (ADP)"
REACT:R-BTA-445757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1 receptor antagonist protein binds Interleukin 1 receptors (Bos taurus)
RHEA:52166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase]
RHEA:45168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spermidine disinapoyl transferase"
RHEA:45168	skos:prefLabel	"spermidine disinapoyl transferase"
RHEA:45168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (E)-sinapoyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine
RHEA:49981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine
REACT:R-XTR-373061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptors CCR3, 4 and 5 bind CCL5 ligand (Xenopus tropicalis)
RHEA:11865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine => dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]
REACT:R-DRE-2046098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of linoleic acid to linoleoyl-CoA (Danio rerio)
REACT:R-CEL-5675790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTORC1 dissociates from ULK complex (Caenorhabditis elegans)
REACT:R-CFA-9755030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPA dimer dephosphorylates RBV-TP to RBV-MP (Canis familiaris)
REACT:R-MMU-5687120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Mus musculus)
RHEA:19294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacylglycerol + ATP => ADP + H(+) + monoacyl-sn-glycero-3-phosphate
REACT:R-BTA-8852306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Bos taurus)
REACT:R-BTA-71670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate + ADP => pyruvate + ATP (Bos taurus)
REACT:R-BTA-2855020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Bos taurus)
RHEA:27638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine
REACT:R-CEL-8877612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND1s exchange GTP for GDP on RAB35 (Caenorhabditis elegans)
RHEA:25930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylquinolin-2(1H)-one + AH2 => 3-methylquinoline + A + H2O
RHEA:55557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroperoxyeicosatetraenoate => an oxoeicosatetraenoate + H2O
REACT:R-GGA-3002811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin phosphatase dephosphorylates PLK1 (Gallus gallus)
REACT:R-HSA-158137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)
RHEA:39799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH
REACT:R-GGA-1169192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTP1B dephosphorylates GHR (Gallus gallus)
REACT:R-BTA-1482546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)
REACT:R-GGA-448632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimerizes (Gallus gallus)
REACT:R-GGA-917696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cargo Sequestration (Gallus gallus)
RHEA:72572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) => dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)
RHEA:30229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+) => dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O
REACT:R-CFA-9606887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)
REACT:R-HSA-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Homo sapiens)
REACT:R-RNO-9638090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)
REACT:R-MMU-158137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Mus musculus)
REACT:R-HSA-8849878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSD-95 binds NMDA receptor (Homo sapiens)
REACT:R-XTR-8981564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)
REACT:R-XTR-9726862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated RHOU translocates to the endosome membrane (Xenopus tropicalis)
REACT:R-DDI-419645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of LIMK1 by Hsp90 (Dictyostelium discoideum)
RHEA:70481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+)
REACT:R-CFA-139899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of BAD protein by 14-3-3 (Canis familiaris)
REACT:R-HSA-201595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of plakophilin-1 (Homo sapiens)
REACT:R-DME-209179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IAP2:BEN:UEV1A E3 ligase complex auto-ubiquitinates (Drosophila melanogaster)
RHEA:65080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:65959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + estrone 3-sulfate(out) + H2O <=> ADP + estrone 3-sulfate(in) + H(+) + phosphate
RHEA:27686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GDP = ADP + GTP
REACT:R-DRE-73758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Danio rerio)
RHEA:61243	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-phenylalanine + O2 <=> 3-phenylpyruvate + H2O2 + NH4(+)
RHEA:39126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA
REACT:R-RNO-450296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)
RHEA:67025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CFA-421833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Canis familiaris)
REACT:R-CEL-69152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of remaining Flap (Caenorhabditis elegans)
RHEA:16846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O + oxaloacetate => citrate + CoA + H(+)
RHEA:31186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + decanoyl-CoA <=> 3-oxododecanoyl-CoA + CoA
REACT:R-RNO-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Rattus norvegicus)
RHEA:19762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN-N(5)-oxide + H(+) + NADH => FMN + H2O + NAD(+)
RHEA:35934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP
REACT:R-CEL-2090038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAGLU hydrolyses heparan chain(2) (Caenorhabditis elegans)
REACT:R-DME-3322014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autoglucosylation of GYG2 complexed with GYS2-a (Drosophila melanogaster)
RHEA:13095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose
REACT:R-MMU-158959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Mus musculus)
REACT:R-HSA-112436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Elongin complex (Homo sapiens)
REACT:R-XTR-5666008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCAI binds SRF:MKL1 (Xenopus tropicalis)
REACT:R-CFA-6792445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPH, I hydrolyse PA to 2-acyl LPA (Canis familiaris)
REACT:R-BTA-983146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Bos taurus)
RHEA:67185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine => (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate
RHEA:43936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androst-5-ene-3,17-dione = androst-4-ene-3,17-dione
GO:0033712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity
GO:0033712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity
GO:0033712	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AFR
REACT:R-CFA-5685994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)
REACT:R-XTR-8849428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 binds PTK6 (Xenopus tropicalis)
RHEA:65593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0016634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
RHEA:25719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-trihomomethionine = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O
REACT:R-XTR-211959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A43 6b-hydroxylates TEST (Xenopus tropicalis)
REACT:R-CFA-3215385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Canis familiaris)
REACT:R-HSA-5654426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
RHEA:29645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + D-maltohexaose => D-maltoheptaose + H2O
REACT:R-HSA-5246514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol (Homo sapiens)
REACT:R-DRE-4719423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS2-2 SUMOylates THRA with SUMO3 (Danio rerio)
REACT:R-HSA-9645414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Homo sapiens)
REACT:R-HSA-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Homo sapiens)
REACT:R-DME-428888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of ROBO1 by ABL kinase (Drosophila melanogaster)
REACT:R-MMU-446634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 is activated by autophosphorylation (Mus musculus)
REACT:R-DME-2105001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from DS (Drosophila melanogaster)
RHEA:42455	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(2-aminophenyl)-2,4-dioxobutanoate <=> H2O + kynurenate
RHEA:65923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-kynurenine + pyruvate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
REACT:R-MMU-1482689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPG is acylated to PG by CRLS1 (IM) (Mus musculus)
REACT:R-XTR-201685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin is released from the destruction complex (Xenopus tropicalis)
REACT:R-DRE-193101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11A1 cleaves 20a,22b-DHCHOL (Danio rerio)
RHEA:53735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate <=> 2-hydroxy-7,8-dihydropteroate + diphosphate
RHEA:67496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end CoA-ribonucleoside in mRNA + H2O = 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)
REACT:R-HSA-8983298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
RHEA:18267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+)
REACT:R-RNO-5621370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK autophosphorylates (Rattus norvegicus)
REACT:R-BTA-917693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESCRT Disassembly (Bos taurus)
REACT:R-SSC-1605724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) (Sus scrofa)
REACT:R-BTA-5340214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYGB binds O2 (Bos taurus)
RHEA:24735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 4-hydroxybutanoate => (R)-2-hydroxyglutarate + succinate semialdehyde
REACT:R-GGA-192434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of diacylglycerols by extracellular PTL:colipase (Gallus gallus)
GO:0004521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endoribonuclease activity
GO:0004521	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	endonuclease G activity
GO:0061922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone propionyltransferase activity
REACT:R-SSC-2423785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CR:atREs binds apoE and HSPG (Sus scrofa)
REACT:R-XTR-6781818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA Pol II initiates transcription from damaged DNA template (Xenopus tropicalis)
RHEA:15088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine
GO:0010943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH pyrophosphatase activity
REACT:R-CFA-1614654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Canis familiaris)
REACT:R-RNO-2426569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and IREM2 (Rattus norvegicus)
RHEA:52906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + coenzyme F430 + phosphate => 15,17(3)-seco-F430-17(3)-acid + ATP
REACT:R-GGA-8869683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxPL binds LBP (Gallus gallus)
REACT:R-MMU-8944232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XII (Mus musculus)
RHEA:28121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose <=> D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP
REACT:R-GGA-2022403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)
REACT:R-CEL-9727567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 hydrolyses sacubitril to sacubitrilat (Caenorhabditis elegans)
RHEA:18957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(R)-limonene 6-monooxygenase"
RHEA:18957	skos:altLabel	"(+)-limonene-6-hydroxylase"
RHEA:18957	skos:prefLabel	"(R)-limonene 6-monooxygenase"
RHEA:18957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:18957	skos:altLabel	"(+)-limonene 6-monooxygenase"
REACT:R-CEL-749453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gz-activating GPCR acts as a GEF for Gz (Caenorhabditis elegans)
RHEA:31945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-CEL-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Caenorhabditis elegans)
RHEA:13211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + 4 H(+) + 3 sulfite => A + 3 H2O + trithionate
REACT:R-HSA-9726949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTGIR binds PTGIR agonists (Homo sapiens)
REACT:R-SSC-74059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Sus scrofa)
RHEA:19826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (+)-aristolochene + diphosphate
RHEA:46822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-DME-499981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Drosophila melanogaster)
REACT:R-GGA-429529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin binding to GP1b:IX:V (Gallus gallus)
RHEA:70305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine => beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol
REACT:R-GGA-2464809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates the transport of atROL from ROS to RPE (Gallus gallus)
RHEA:39150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA
REACT:R-MMU-176879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apolipoprotein(a) + LDL => Lp(a) (Mus musculus)
REACT:R-HSA-156832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	INF-gamma induced phosphorylation of L13a (Homo sapiens)
REACT:R-MMU-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Mus musculus)
RHEA:18015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethylamine + L-glutamate => H2O + N(5)-ethyl-L-glutamine
REACT:R-SSC-5669158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF2 binds PAK1 (Sus scrofa)
RHEA:36957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA
REACT:R-XTR-5694446	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Xenopus tropicalis)
REACT:R-DRE-8852019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET bound PI3K generates PIP3 (Danio rerio)
REACT:R-CFA-981535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD55 (DAF) binds C3bBb, C4bC2a (Canis familiaris)
REACT:R-XTR-5686398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPIDR binds BLM:TOP3A:RMI1:RMI2 (Xenopus tropicalis)
REACT:R-CFA-6805399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAF1 phosphorylates TP53 (Canis familiaris)
RHEA:37708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
REACT:R-RNO-9717834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGPS1 hexamer transfers IPPP to DMAPP (Rattus norvegicus)
RHEA:49329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-DRE-1067651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Danio rerio)
REACT:R-DRE-5676940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Danio rerio)
RHEA:36073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + tulipalin A => 6-tuliposide A
RHEA:16486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate => 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate
REACT:R-SSC-166753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of C4 into C4a and C4b (Sus scrofa)
REACT:R-SSC-3295579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPs transport extracellular Ca2+ to cytosol (Sus scrofa)
RHEA:66389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + prostaglandin E2(in) => ADP + H(+) + phosphate + prostaglandin E2(out)
REACT:R-CFA-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Canis familiaris)
REACT:R-SSC-5690845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNIPs bind TNFAIP3 (A20) (Sus scrofa)
REACT:R-SSC-2187375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD3 binds STUB1 (CHIP) (Sus scrofa)
RHEA:70392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + eicosanoyl-CoA => CoA + H(+) + N-eicosanoyl-3-oxosphinganine
REACT:R-BTA-9021357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRKCI phosphorylates ELF3 (Bos taurus)
REACT:R-HSA-2466369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)
REACT:R-MMU-2730872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Calcineurin (Mus musculus)
RHEA:64583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + nerylneryl diphosphate
GO:0051212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vanadium ion binding
GO:0051212	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	V ion binding
REACT:R-DRE-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Danio rerio)
REACT:R-SSC-212005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2F1 dehydrogenates 3-methylindole (Sus scrofa)
RHEA:20155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-L-arabinose 1-phosphate + H(+) => ATP + L-arabinose
RHEA:16929	skos:prefLabel	"ornithine N-benzoyltransferase"
RHEA:16929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 benzoyl-CoA + L-ornithine = 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine
RHEA:16929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ornithine N-benzoyltransferase"
REACT:R-DME-6788597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Drosophila melanogaster)
RHEA:53742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-L-tyrosine + AMP + H(+) => [Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O
EC:2.8.2.29	skos:prefLabel	"[heparan sulfate]-glucosamine 3-sulfotransferase 2"
EC:2.8.2.29	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[heparan sulfate]-glucosamine 3-sulfotransferase 2"
EC:2.8.2.29	skos:altLabel	"heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2"
EC:2.8.2.29	skos:altLabel	"3-OST-2"
EC:2.8.2.29	skos:altLabel	"glucosaminyl 3-O-sulfotransferase 2"
REACT:R-DRE-749456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Danio rerio)
REACT:R-GGA-5674022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP autoubiquitinates (Gallus gallus)
REACT:R-SSC-204008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEC31:SEC13 and v-SNARE recruitment (Sus scrofa)
RHEA:42051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH
RHEA:25042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + 2 phosphate
RHEA:39803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH
REACT:R-DRE-3229102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPKAPK3 phosphorylates BMI1 (Danio rerio)
REACT:R-MMU-450095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Mus musculus)
REACT:R-BTA-4419948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTDNEP1:CNEP1R1 dephosphorylates LPIN (Bos taurus)
RHEA:52747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclobis-(1->3)-alpha-D-isomaltosyl + H2O <=> alpha-isomaltosyl-(1->3)-isomaltose
RHEA:22848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-hydroxyoctanedioyl-CoA + NAD(+) = 3-oxooctanedioyl-CoA + H(+) + NADH
REACT:R-RNO-5250938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Rattus norvegicus)
RHEA:68186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a medium chain fatty acid + CoA + H(+) => a medium-chain fatty acyl-CoA + H2O
RHEA:40408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-RNO-1168643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCP ubiquitinylates IkB (Rattus norvegicus)
RHEA:22405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galacturonate + NAD(+) => D-galactaro-1,5-lactone + H(+) + NADH
RHEA:21723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formamide <=> H2O + hydrogen cyanide
RHEA:46012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + a quinone = a quinol + oxaloacetate
REACT:R-SSC-5223304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)
RHEA:71345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-histidine(in) + 2 Na(+)(in) => chloride(out) + L-histidine(out) + 2 Na(+)(out)
REACT:R-BTA-380278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Bos taurus)
REACT:R-MMU-9757688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINA6 binds PREDN (Mus musculus)
REACT:R-SSC-5218916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-MAPK2/3 phosphorylates HSP27 (Sus scrofa)
RHEA:52461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP
REACT:R-HSA-9617087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds the promoter of the GFI1 gene (Homo sapiens)
GO:0052620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thymine dehydrogenase activity
RHEA:18388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetone + 2 ATP + 3 H2O + hydrogencarbonate <=> acetoacetate + 2 AMP + 4 H(+) + 4 phosphate
REACT:R-RNO-5697009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Rattus norvegicus)
RHEA:15743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-dichlorohydroquinone + H(+) + NADH => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+)
REACT:R-MMU-1483087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is exchanged with PC by PITPNB (Mus musculus)
REACT:R-BTA-212552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase 3-mediated cleavage of PKC delta (Bos taurus)
RHEA:71223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + 2 Na(+)(out) + taurine(out) = chloride(in) + 2 Na(+)(in) + taurine(in)
RHEA:69770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-non-2-enal + H2O + NAD(+) <=> (E)-non-2-enoate + 2 H(+) + NADH
REACT:R-HSA-5685318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCDX2 complex formation (Homo sapiens)
REACT:R-HSA-6809354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT (Homo sapiens)
REACT:R-CEL-8875838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Caenorhabditis elegans)
RHEA:69158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein + N-(4-aminobutyl)-3-aminopropanal => spermine dialdehyde
REACT:R-SSC-5663050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHI and DHICA polymerise forming eumelanin (Sus scrofa)
REACT:R-XTR-8865605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRWD1 binds SMARCA4 (Xenopus tropicalis)
REACT:R-BTA-211929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C19 5-hydroxylates omeprazole (Bos taurus)
RHEA:19322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N-dimethylaniline N-oxide => formaldehyde + N-methylaniline
REACT:R-HSA-73916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Homo sapiens)
REACT:R-RNO-8954110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6:TFDP1:EPC1 binds the PRC2 complex (Rattus norvegicus)
REACT:R-CFA-879201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bcl-2 and Bcl-XL bind NLRP1 (Canis familiaris)
REACT:R-XTR-352347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Xenopus tropicalis)
REACT:R-SSC-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Sus scrofa)
REACT:R-DRE-382056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Crk binds to the active PDGF receptor (Danio rerio)
REACT:R-HSA-8847912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNPLA7 hydrolyzes LysoPtdCho (Homo sapiens)
RHEA:20491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala)
REACT:R-HSA-6814682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
GO:0047535	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity
GO:0047535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-alkyn-1-ol dehydrogenase"
GO:0047535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH
GO:0047535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-alkyn-1-ol dehydrogenase activity
GO:0047535	skos:prefLabel	"2-alkyn-1-ol dehydrogenase"
REACT:R-XTR-8952873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECR dimer reduces tdec2-CoA to DEC-CoA (Xenopus tropicalis)
REACT:R-HSA-8987042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)
REACT:R-CFA-5696839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Canis familiaris)
REACT:R-SPO-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Schizosaccharomyces pombe)
RHEA:42403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + lactose 6-phosphate(in)
RHEA:47692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + neomycin C + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B
REACT:R-MMU-9613264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Mus musculus)
RHEA:10878	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + phenol => 4-hydroxybenzoate + H(+)
REACT:R-DRE-8849102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRMS phosphorylates PTK6 (Danio rerio)
REACT:R-HSA-8987161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Homo sapiens)
REACT:R-DRE-5662660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopachrome is transformed to DHICA by DCT (Danio rerio)
GO:0000978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding
GO:0000978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0000978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000978	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNA polymerase II promoter proximal region sequence-specific DNA binding
RHEA:39754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-163664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP binds to gamma subunit of AMP kinase heterotrimer (Rattus norvegicus)
REACT:R-HSA-388596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanocortin receptors bind melanocortins (Homo sapiens)
REACT:R-XTR-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Xenopus tropicalis)
REACT:R-BTA-5674366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RD binds p-2S MAP2Ks and MAPKs (Bos taurus)
RHEA:48634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
RHEA:35474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> (+)-pisatin + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-8864569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WWOX binds TFAP2C (Caenorhabditis elegans)
RHEA:25814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acetamidopropanal + H2O2 + putrescine => H2O + N(1)-acetylspermidine + O2
REACT:R-PFA-6801456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Plasmodium falciparum)
RHEA:68072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH = L-thiazolidine-2-carboxylate + NADP(+)
RHEA:30298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + pyruvate <=> GDP + H(+) + phosphoenolpyruvate
REACT:R-GGA-141437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the MCC complex (Gallus gallus)
RHEA:18218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + an alkane-alpha,omega-diamine => an omega-aminoaldehyde + L-glutamate
REACT:R-CEL-9010872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2 binds Dystroglycan (Caenorhabditis elegans)
REACT:R-BTA-6785594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCD2 binds FANCI (Bos taurus)
REACT:R-DRE-1306953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
RHEA:46105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => corticosterone + H2O + 2 oxidized [adrenodoxin]
RHEA:26010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)
REACT:R-GGA-396996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs binds G-protein Gq (Gallus gallus)
RHEA:33759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-oxo-fatty acyl-CoA + H(+) + NADPH = a 3-hydroxy-fatty acyl-CoA + NADP(+)
GO:0051753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannan synthase activity
GO:0051753	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	galactomannan beta-1,4-mannosyltransferase activity
GO:0051753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mannan beta-1,4-mannosyltransferase activity
GO:0102185	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity
RHEA:25759	skos:prefLabel	"ent-isokaurene synthase"
RHEA:25759	skos:altLabel	"ent-isokaur-15-ene synthase"
RHEA:25759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ent-isokaurene synthase"
RHEA:25759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate = diphosphate + ent-isokaurene
REACT:R-DRE-3968414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Danio rerio)
RHEA:31523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + 2 H(+) + O2 = 3 CO2 + ethene + H2O
RHEA:31523	skos:altLabel	"ethylene-forming enzyme"
RHEA:31523	skos:prefLabel	"2-oxoglutarate dioxygenase (ethylene-forming)"
RHEA:31523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-oxoglutarate dioxygenase (ethylene-forming)"
RHEA:50674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O
RHEA:60086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4alpha-methyl-3-oxosteroid + CO2 + NADH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+)
RHEA:46368	skos:prefLabel	"Delta(12) acyl-lipid conjugase (11E,13E-forming)"
RHEA:46368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Delta(12) acyl-lipid conjugase (11E,13E-forming)"
RHEA:46368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46368	skos:altLabel	"fatty acid Delta(12)-conjugase"
RHEA:46368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:40197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate
REACT:R-HSA-8950485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Homo sapiens)
REACT:R-HSA-8954056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP2 (Homo sapiens)
REACT:R-XTR-8866542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Xenopus tropicalis)
RHEA:25252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 pyruvate <=> (2S)-2-acetolactate + CO2
REACT:R-DRE-190413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR2c (Danio rerio)
REACT:R-CFA-5675194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPK phosphorylates RAF1 (Canis familiaris)
RHEA:22095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] <=> 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]
RHEA:57381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-5674018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds RAS:GTP (Rattus norvegicus)
REACT:R-DRE-5649799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Danio rerio)
RHEA:62305	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine => (+)-premalbrancheamide
REACT:R-SSC-981621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3 convertases spontaneously dissociate (Sus scrofa)
RHEA:29791	skos:altLabel	"glutathione transporting ATPase"
RHEA:29791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ABC-type glutathione transporter"
RHEA:29791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) + phosphate
RHEA:29791	skos:prefLabel	"ABC-type glutathione transporter"
RHEA:29791	skos:altLabel	"glutathione ABC transporter"
REACT:R-DME-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)
REACT:R-SPO-1482828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Schizosaccharomyces pombe)
REACT:R-RNO-5610726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The IFT-A complex recruits TULP3 (Rattus norvegicus)
REACT:R-DME-1475022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase dehydrates bicarbonate (cytosol) (Drosophila melanogaster)
GO:0045516	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-19 receptor ligand
GO:0045516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-19 receptor binding
GO:0045516	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-19
RHEA:33222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Canis familiaris)
REACT:R-RNO-2130486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoating of clathrin-coated vesicles and fusion with endosomes (Rattus norvegicus)
RHEA:23000	skos:prefLabel	"pantoate 4-dehydrogenase"
RHEA:23000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pantoate 4-dehydrogenase"
RHEA:23000	skos:altLabel	"Panthothenase"
RHEA:23000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH
RHEA:56371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)
REACT:R-HSA-189439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALAD condenses 2 dALAs to form PBG (Homo sapiens)
REACT:R-HSA-4655374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DNMT3B with SUMO1 (Homo sapiens)
REACT:R-SSC-1295621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)
REACT:R-CEL-211960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2U1 19-hydroxylates ARA (Caenorhabditis elegans)
REACT:R-BTA-5635865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 dissociates from ub-PTCH1 (Bos taurus)
GO:0015304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucose uniporter activity
GO:0015304	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	galactose, glucose uniporter activity
GO:0050342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocotrienol + S-adenosyl-L-methionine = alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine
GO:0050342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocopherol methyltransferase activity
GO:0050342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tocopherol O-methyltransferase activity
GO:0050342	skos:altLabel	"tocopherol O-methyltransferase"
GO:0050342	skos:prefLabel	"tocopherol C-methyltransferase"
GO:0050342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tocopherol C-methyltransferase"
GO:0050342	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity
RHEA:31544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-zeaxanthin + 2 UDP-alpha-D-glucose => 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)
RHEA:29408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)
REACT:R-XTR-8851110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase3 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)
REACT:R-HSA-428690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Homo sapiens)
REACT:R-DRE-6800149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Danio rerio)
RHEA:43326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
REACT:R-CEL-192137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
RHEA:66959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)
REACT:R-PFA-2395517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH transfers electrons to FDXR (Plasmodium falciparum)
GO:0009881	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	violet-sensitive opsin
GO:0009881	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	blue-sensitive opsin
GO:0009881	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	short-wave-sensitive opsin
GO:0009881	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	UV-sensitive opsin
GO:0009881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	photoreceptor activity
GO:0009881	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	green-sensitive opsin
GO:0009881	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	long-wave-sensitive opsin
GO:0009881	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	opsin
GO:0009881	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	red-sensitive opsin
REACT:R-SSC-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Sus scrofa)
REACT:R-HSA-4539779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type IV binds integrin alpha10beta1 (Homo sapiens)
RHEA:50843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate
REACT:R-DRE-8865276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AB clevage by Furin (Danio rerio)
REACT:R-MMU-9664888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Mus musculus)
RHEA:31148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxyphenylethyleneglycol + NAD(+) => 3,4-dihydroxymandelaldehyde + H(+) + NADH
GO:0005186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pheromone activity
REACT:R-HSA-4331340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
RHEA:56967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate
RHEA:60751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin II
REACT:R-SSC-444047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Receptor FFAR3 binds carboxylates (Sus scrofa)
REACT:R-XTR-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Xenopus tropicalis)
RHEA:66057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole-3-pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan
RHEA:39527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)
RHEA:20384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androsterone + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH
REACT:R-DME-199203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK1/3/4 phosphorylate PanK (Drosophila melanogaster)
RHEA:16535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
RHEA:58227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamyl-[protein] + NAD(+) <=> 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide
REACT:R-HSA-9753676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT1,2 acetylate APAP-Cys to APAP-Mer (Homo sapiens)
REACT:R-CEL-5694077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Caenorhabditis elegans)
REACT:R-XTR-192097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Xenopus tropicalis)
RHEA:41133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-decanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-decanoyl-sn-glycero-3-phosphocholine + H2O
REACT:R-SSC-8877153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STARD7 binds PC (Sus scrofa)
REACT:R-GGA-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Gallus gallus)
REACT:R-BTA-5690790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Histone H2A is dubiquitinated by the PR-DUB complex (Bos taurus)
REACT:R-RNO-1234175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Rattus norvegicus)
RHEA:46628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH = androst-5-en-3beta,17beta-diol + NADP(+)
RHEA:19628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine <=> acetaldehyde + glycine
GO:0106369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP
GO:0106369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)nucleoside phosphate kinase activity, GTP as phosphate donor
REACT:R-BTA-112396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Separation of elongating transcript from template (Bos taurus)
EC:3.2.1.111	skos:prefLabel	"1,3-alpha-L-fucosidase"
EC:3.2.1.111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,3-alpha-L-fucosidase"
EC:3.2.1.111	skos:altLabel	"almond emulsin fucosidase I"
REACT:R-MMU-5665982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Mus musculus)
RHEA:29916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP
RHEA:70971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-dopa + H2O + O2 = 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)
RHEA:59249	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA => (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA
REACT:R-XTR-8938076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD38 hydrolyses NAD+ to NAM and ADP-ribose (Xenopus tropicalis)
RHEA:38847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate
REACT:R-GGA-1247645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from cytosol to extracellular region (Gallus gallus)
REACT:R-SSC-388529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholecystokinin receptors bind cholecystokinin (Sus scrofa)
REACT:R-DME-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Drosophila melanogaster)
REACT:R-DDI-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Dictyostelium discoideum)
REACT:R-CFA-5625849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Demethylase KDM1A binds KLK2 and KLK3 promoters (Canis familiaris)
REACT:R-HSA-392300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
REACT:R-DRE-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Danio rerio)
REACT:R-XTR-196402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Xenopus tropicalis)
RHEA:42057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-cis-retinol + NAD(+) => 13-cis-retinal + H(+) + NADH
RHEA:53456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)
REACT:R-DDI-1855225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Dictyostelium discoideum)
REACT:R-CFA-6811504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 dephosphorylation by PP2A-B56-beta,gamma (Canis familiaris)
REACT:R-HSA-6802911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
RHEA:42792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA
REACT:R-DRE-74948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates p-RHO to RHO (Danio rerio)
RHEA:18135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + diphosphate => ATP + H(+) + sulfate
REACT:R-SSC-5694137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Sus scrofa)
REACT:R-MMU-8950522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1:p-STAT4 translocates to the nucleus (Mus musculus)
RHEA:58255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] <=> ADP-D-ribose + L-asparaginyl-[protein]
REACT:R-DRE-373745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SDK1 homophillic interaction (Danio rerio)
GO:0000146	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	muscle motor activity
GO:0000146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin-activated ATPase activity
GO:0000146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin-dependent ATPase activity
GO:0000146	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myosin ATPase activity
GO:0000146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin-filament motor activity
GO:0000146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	actin filament motor activity
GO:0000146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	microfilament motor activity
REACT:R-DRE-140806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SERPINC1 binds SERPINC1 activators (Danio rerio)
REACT:R-RNO-2032775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD1 (Rattus norvegicus)
RHEA:64224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O
REACT:R-GGA-1433428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2 is indirectly recruited to p-KIT through SHP2 (Gallus gallus)
REACT:R-CFA-5693373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)
REACT:R-HSA-9698003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3 mutants phosphorylate GAB2 (Homo sapiens)
REACT:R-DME-389986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Drosophila melanogaster)
REACT:R-BTA-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Bos taurus)
REACT:R-RNO-110307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REV1 binds AP-dsDNA (Rattus norvegicus)
REACT:R-RNO-8943817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Rattus norvegicus)
RHEA:18073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-dihydroorotate + A = AH2 + orotate
REACT:R-SSC-165777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation and activation of eIF4B by activated S6K1 (Sus scrofa)
RHEA:16296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate
RHEA:47436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,7Z)-hexadecadienoyl-CoA + H2O = (3S)-hydroxy-(7Z-hexadecenoyl)-CoA
RHEA:14618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + glutathione + NADP(+) => CoA-glutathione + H(+) + NADPH
REACT:R-GGA-3465429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)
RHEA:39671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-hexadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O
REACT:R-RNO-5654397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 phosphorylates FRS2 (Rattus norvegicus)
GO:0008289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lipid binding
RHEA:18349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)
RHEA:18349	skos:altLabel	"nondiscriminating aspartyl-tRNA synthetase"
RHEA:18349	skos:prefLabel	"aspartate--tRNA(Asn) ligase"
RHEA:18349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate--tRNA(Asn) ligase"
RHEA:66205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptanoyl-CoA + O2 => (2E)-heptenoyl-CoA + H2O2
GO:0035373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin sulfate proteoglycan binding
REACT:R-CEL-508369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Caenorhabditis elegans)
REACT:R-DRE-2167942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII ectodomain shedding (Danio rerio)
REACT:R-SPO-442393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP7 mediates zinc efflux from the endoplasmic reticulum (Schizosaccharomyces pombe)
REACT:R-DDI-6807052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EBP isomerizes ZYMSTNL to LTHSOL (Dictyostelium discoideum)
GO:0010301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	xanthoxin dehydrogenase activity
GO:0010301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthoxin:NAD+ oxidoreductase activity
GO:0010301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ABA2
GO:0010301	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	xanthoxin oxidase activity
RHEA:27690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dGDP = ADP + dGTP
REACT:R-BTA-8852716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin, ELANE cleave C5 (Bos taurus)
REACT:R-CEL-749456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Caenorhabditis elegans)
RHEA:17701	skos:altLabel	"geranyl-CoA carboxylase"
RHEA:17701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + geranoyl-CoA + hydrogencarbonate = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate
RHEA:17701	skos:prefLabel	"geranoyl-CoA carboxylase"
RHEA:17701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"geranoyl-CoA carboxylase"
GO:0052870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tocopherol 13-hydroxylase activity
GO:0052870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tocopherol omega-hydroxylase activity
REACT:R-CFA-2512800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCARB1:ligand is endocytosed (Canis familiaris)
REACT:R-XTR-8944219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVI (Xenopus tropicalis)
RHEA:40013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + manool => (+)-copalyl diphosphate + H2O
REACT:R-XTR-75098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mRNP complex dissociates from cytosolic face of NPC (Xenopus tropicalis)
REACT:R-GGA-450474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MK2 phosphorylates BRF1 (Gallus gallus)
REACT:R-SSC-110226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of cytosine glycol by NTHL1 glycosylase (Sus scrofa)
REACT:R-MMU-418309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Mus musculus)
REACT:R-CFA-1433471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of RAS by p-KIT bound SOS1 (Canis familiaris)
REACT:R-BTA-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Bos taurus)
REACT:R-DRE-6806674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Danio rerio)
RHEA:16861	skos:altLabel	"DAPA aminotransferase"
RHEA:16861	skos:prefLabel	"adenosylmethionine--8-amino-7-oxononanoate transaminase"
RHEA:16861	skos:altLabel	"Adenosylmethionine--8-amino-7-oxononanoate aminotransferase"
RHEA:16861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylmethionine--8-amino-7-oxononanoate transaminase"
RHEA:16861	skos:altLabel	"7,8-diamino-pelargonic acid aminotransferase"
RHEA:16861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate
RHEA:16861	skos:altLabel	"7,8-diaminononanoate aminotransferase"
REACT:R-HSA-9761344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 binds IKBKG within IKK complex (Homo sapiens)
RHEA:21047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylidenelophenol + S-adenosyl-L-methionine <=> (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-175987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NNMT transfers CH3 from AdoMet to PY (Homo sapiens)
RHEA:63136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UMP/CMP kinase"
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	dCMP kinase activity
GO:0004127	skos:prefLabel	"UMP/CMP kinase"
GO:0004127	skos:altLabel	"dCMP kinase"
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytidine monophosphate kinase activity
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidylate kinase activity
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTP:CMP phosphotransferase activity
GO:0004127	skos:altLabel	"cytidylate kinase"
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	deoxycytidine monophosphokinase activity
GO:0004127	skos:altLabel	"uridine monophosphate-cytidine monophosphate phosphotransferase"
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	deoxycytidylate kinase activity
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CMP kinase activity
GO:0004127	skos:altLabel	"UMP-CMP kinase"
GO:0004127	skos:altLabel	"deoxycytidine kinase"
GO:0004127	skos:altLabel	"deoxycytidylate kinase"
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UMP-CMP kinase activity
GO:0004127	skos:altLabel	"cytidine monophosphate kinase"
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:UMP-CMP phosphotransferase activity
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	pyrimidine nucleoside monophosphate kinase activity
GO:0004127	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:CMP phosphotransferase activity
GO:0004127	skos:altLabel	"CMP kinase"
REACT:R-HSA-199298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates CREB1 (Homo sapiens)
RHEA:16717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + FAD + H(+) + H2O = cholate + FADH2
RHEA:70686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-normetanephrine + S-adenosyl-L-methionine <=> (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine
REACT:R-RNO-186785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDGF-AA clevage by Furin (Rattus norvegicus)
RHEA:53956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-L-glutamyl-[BtrI ACP] + H(+) = 4-aminobutanoyl-[BtrI ACP] + CO2
RHEA:53956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-glutamyl-[BtrI acyl-carrier protein] decarboxylase"
RHEA:53956	skos:prefLabel	"L-glutamyl-[BtrI acyl-carrier protein] decarboxylase"
RHEA:47114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate + H2O => chenodeoxycholate + glycine
RHEA:37124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine
GO:0005332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GABA:sodium symporter activity
GO:0005332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutyrate:sodium symporter activity
GO:0005332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAT1-3 mediate Na+/Cl- dependent GABA transport (Homo sapiens)
GO:0005332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	betaine/GABA:sodium symporter activity
GO:0005332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid:sodium symporter activity
GO:0005332	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sodium/chloride-dependent GABA transporter activity
GO:0005332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate:sodium symporter activity
GO:0005332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminobutyric acid:sodium:chloride symporter activity
REACT:R-BTA-9603775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX3:PEX19:class I PMP dissociates (Bos taurus)
GO:0004780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sulfate (adenosine diphosphate) adenylyltransferase activity
GO:0004780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulfate adenylyltransferase (ADP) activity
GO:0004780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ADP-sulfurylase activity
GO:0004780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sulphate adenylyltransferase (ADP) activity
GO:0004780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP:sulfate adenylyltransferase activity
GO:0004780	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	adenosine diphosphate sulfurylase activity
RHEA:72841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP(in) + CoA(out) => ADP(out) + CoA(in)
RHEA:15449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate + O2 = 4-maleylacetoacetate + H(+)
RHEA:15449	skos:altLabel	"homogentisic acid oxidase"
RHEA:15449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homogentisate 1,2-dioxygenase"
RHEA:15449	skos:altLabel	"homogentisicase"
RHEA:15449	skos:altLabel	"homogentisate oxygenase"
RHEA:15449	skos:prefLabel	"homogentisate 1,2-dioxygenase"
REACT:R-HSA-196372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Homo sapiens)
REACT:R-MMU-9641109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Mus musculus)
REACT:R-HSA-918232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of IRF3,IRF7 (Homo sapiens)
RHEA:35429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside => 1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside
RHEA:12131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-BTA-9015122	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor Xa inhibitors bind Va:Xa (Bos taurus)
REACT:R-HSA-351222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Homo sapiens)
RHEA:68601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfopropanediol => 3-oxopropane-1-sulfonate + H2O
REACT:R-CEL-163670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear transport of pChREBP (Thr 666) protein (Caenorhabditis elegans)
RHEA:49959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-dihydrophenazine 1-carboxylate + O2 <=> H2O2 + phenazine-1-carboxylate
REACT:R-RNO-9759206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Rattus norvegicus)
REACT:R-GGA-9627056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Procaspase 9 forms dimer (Gallus gallus)
RHEA:43433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butan-1-ol + 2 Fe(III)-[cytochrome c] => butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)
REACT:R-MMU-1295634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is serine phosphorylated in response to MAPK activation (Mus musculus)
REACT:R-MMU-8864577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2C translocates to the nucleus (Mus musculus)
RHEA:59401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-2-aminohexanoate => D-2-aminohexanoate
RHEA:63728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta-D-glucuronide + UDP
RHEA:44170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + H2O + NAD(+) => dodecanoate + 2 H(+) + NADH
REACT:R-HSA-8874192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves CREB3 (Homo sapiens)
REACT:R-CEL-8950724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Caenorhabditis elegans)
RHEA:10976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxyquinoline 5,6-dioxygenase"
RHEA:10976	skos:altLabel	"2-oxo-1,2-dihydroquinoline 5,6-dioxygenase"
RHEA:10976	skos:altLabel	"quinolin-2(1H)-one 5,6-dioxygenase"
RHEA:10976	skos:altLabel	"quinolin-2-ol 5,6-dioxygenase"
RHEA:10976	skos:prefLabel	"2-hydroxyquinoline 5,6-dioxygenase"
RHEA:10976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + quinolin-2-ol = 5,6-dihydroquinoline-2,5,6-triol + NAD(+)
REACT:R-DRE-158784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Danio rerio)
REACT:R-BTA-352371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Bos taurus)
REACT:R-BTA-2395872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)
REACT:R-CFA-6811425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF and SNAPs bind cis-SNARE at the ER membrane (Canis familiaris)
RHEA:49780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + glycine = CoA + H(+) + N-docosanoylglycine
REACT:R-CEL-1250195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 phosphorylation by ERBB2 heterodimers (Caenorhabditis elegans)
GO:0000285	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type III PIP kinase activity
GO:0000285	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity
GO:0000285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol-3-phosphate 5-kinase activity
GO:0000285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0000285	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylinositol 3-phosphate 5-kinase activity
GO:0033041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sweet taste receptor activity
RHEA:65159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + preaustinoid A2 <=> CO2 + H2O + preaustinoid A3 + succinate
GO:0034025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-MurNAc-pentapeptide:D-aspartate ligase activity
GO:0034025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aspartic acid-activating enzyme
GO:0034025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aslfm
GO:0034025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-aspartate ligase activity
GO:0034025	skos:altLabel	"Aslfm"
GO:0034025	skos:altLabel	"D-aspartic acid-activating enzyme"
GO:0034025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-aspartate ligase"
GO:0034025	skos:prefLabel	"D-aspartate ligase"
GO:0034025	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity
GO:0034025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate
REACT:R-RNO-8858298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRASLS transfer acyl group from PC to PE to form NAPE (Rattus norvegicus)
RHEA:20755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + 2 cob(II)alamin + 2 H(+) + 2 H2O <=> AH2 + 2 aquacob(III)alamin
GO:0018820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urea hydro-lyase activity
GO:0018820	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urea hydro-lyase (cyanamide-forming)
GO:0018820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanamide hydratase activity
REACT:R-CFA-9706287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active FLT3 binds to ABL2 (Canis familiaris)
RHEA:12689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 mycothiol + NAD(+) = H(+) + mycothione + NADH
REACT:R-HSA-5683593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG7:ATG3:LC3 dissociates (Homo sapiens)
GO:0008296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5' exodeoxyribonuclease activity
GO:0008296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (Homo sapiens)
GO:0008296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5'-exodeoxyribonuclease activity
REACT:R-RNO-6788798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK4 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)
EC:1.1.1.168	skos:altLabel	"2-ketopantoyl lactone reductase"
EC:1.1.1.168	skos:altLabel	"2-dehydropantoyl-lactone reductase (A-specific)"
EC:1.1.1.168	skos:prefLabel	"2-dehydropantolactone reductase (Re-specific)"
EC:1.1.1.168	skos:altLabel	"2-dehydropantolactone reductase (A-specific)"
EC:1.1.1.168	skos:altLabel	"ketopantoyl lactone reductase"
EC:1.1.1.168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-dehydropantolactone reductase (Re-specific)"
RHEA:48720	skos:prefLabel	"aurachin B dehydrogenase"
RHEA:48720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aurachin B dehydrogenase"
RHEA:48720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aurachin B + H2O + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH
REACT:R-DRE-159443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Danio rerio)
RHEA:52583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Pb(2+)(in) <=> ADP + H(+) + Pb(2+)(out) + phosphate
RHEA:46904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) = a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)
REACT:R-MMU-8936851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AHRR binds ARNT (Mus musculus)
REACT:R-DRE-168053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs phosphorylate ATF-2 (Danio rerio)
RHEA:41919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]
RHEA:12636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate + H(+) + NADH + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)
REACT:R-MMU-400204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPARA binds RXRA (Mus musculus)
REACT:R-SSC-9757574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds PREDL (Sus scrofa)
REACT:R-MMU-1855225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Mus musculus)
REACT:R-XTR-8941618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)
REACT:R-DRE-8855711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Danio rerio)
REACT:R-MMU-2424481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)
REACT:R-MMU-2168888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha1-Microglobulin binds heme (Mus musculus)
REACT:R-RNO-8875318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3 GEFs exchange GTP for GDP on RAB3A (Rattus norvegicus)
REACT:R-SSC-870538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Sus scrofa)
REACT:R-PFA-727749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Plasmodium falciparum)
RHEA:34040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + neamine => 6'-oxoparomamine + L-glutamate
RHEA:37159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
REACT:R-DME-354124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pPTK2 by SRC (Drosophila melanogaster)
REACT:R-HSA-8952996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F7 forms homodimers (Homo sapiens)
REACT:R-DRE-8869456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP4 deubiquitinate TRAF2,TRAF6 (Danio rerio)
REACT:R-BTA-9604487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7:p-IRF7 translocates to the nucleus (Bos taurus)
REACT:R-BTA-9032073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2-phosphorylated FRS2 binds GRB2 (Bos taurus)
RHEA:21233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine => NH4(+) + trans-urocanate
RHEA:48503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octanoylglycerol <=> glycerol + H(+) + octanoate
REACT:R-DRE-1253300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4 binds WWP1/ITCH ubiquitin ligases (Danio rerio)
REACT:R-DME-432378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nuclear JET binds CRY, facilitating its ubiquitination (Drosophila melanogaster)
RHEA:42907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(748) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine
REACT:R-MMU-5668454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Mus musculus)
REACT:R-MMU-8863494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASICs bind STOML3, (STOM) (Mus musculus)
REACT:R-GGA-4086205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN (osteopontin) degradation by MMP3, MMP7 (Gallus gallus)
REACT:R-MMU-73580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Mus musculus)
REACT:R-XTR-6799199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Xenopus tropicalis)
REACT:R-XTR-6799581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Xenopus tropicalis)
RHEA:18262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + precorrin-5 + S-adenosyl-L-methionine => acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine
RHEA:29671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ca(2+)(in) = Ca(2+)(out)
REACT:R-SSC-204813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Grb14 (Sus scrofa)
REACT:R-CEL-8852132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
REACT:R-DDI-73769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loss of Rrn3 from RNA Polymerase I promoter escape complex (Dictyostelium discoideum)
RHEA:21475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + CoA <=> (3S)-citryl-CoA + ADP + phosphate
RHEA:38023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol
GO:0042925	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoate transporter activity
GO:0042925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate transmembrane transporter activity
GO:0042925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoate(in) = benzoate(out)
RHEA:39016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	22-oxodocosanoate + H2O + NAD(+) => docosanedioate + 2 H(+) + NADH
REACT:R-GGA-353271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by Uracil-glycosylase (Gallus gallus)
RHEA:43702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine => (2E,6E)-farnesoate + S-adenosyl-L-methionine
REACT:R-XTR-381109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1 binds IRE1 forming dimer (Xenopus tropicalis)
EC:2.7.1.7	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mannokinase"
EC:2.7.1.7	skos:prefLabel	"mannokinase"
RHEA:34536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexadecanoyl-CoA + L-alanine => 1-deoxy-3-dehydrosphinganine + CO2 + CoA
RHEA:44559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-hexaprenyl diphosphate <=> 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate
RHEA:11307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-ureidoglycolate <=> glyoxylate + urea
RHEA:62616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)
RHEA:60789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A24 + H(+) + O2 => CO2 + gibberellin A9 + H2O
REACT:R-CEL-162425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S295-PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
REACT:R-CFA-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)
REACT:R-CEL-2730959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLCN7:OSTM1 exchanges Cl- for H+ (Caenorhabditis elegans)
REACT:R-HSA-1475436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Homo sapiens)
REACT:R-DME-75850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the third nucleotide on the nascent transcript (Drosophila melanogaster)
RHEA:27313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	naphthalene-1,2-diol + O2 <=> 2-hydroxychromene-2-carboxylate + H(+)
RHEA:17394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-maleylpyruvate => 3-fumarylpyruvate
REACT:R-HSA-2317332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3 recruits AKT to the membrane (Homo sapiens)
RHEA:32746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homocysteine + O-acetyl-L-serine <=> acetate + H(+) + L,L-cystathionine
REACT:R-DME-5624494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 binds p21 RAS:GTP (Drosophila melanogaster)
REACT:R-CFA-167429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex  binds GTP (Canis familiaris)
REACT:R-RNO-5610766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Rattus norvegicus)
RHEA:43468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoate + O2 = (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate
REACT:R-SSC-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Sus scrofa)
RHEA:70994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-mannopyranose(in) <=> H(+)(out) + L-mannopyranose(out)
RHEA:72556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(out) + propanoate(in) => estrone 3-sulfate(in) + propanoate(out)
REACT:R-HSA-419644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of pLIMK1 (Homo sapiens)
RHEA:71062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-leucine(out) <=> L-arginine(out) + L-leucine(in)
RHEA:55355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinol <=> 13-cis-retinol
REACT:R-HSA-216058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Homo sapiens)
REACT:R-CFA-417843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y13 binds ADP (Canis familiaris)
REACT:R-DRE-5696358	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TREM,CD300 binds lipids (Danio rerio)
RHEA:19930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP
RHEA:49532	skos:altLabel	"MHET hydrolase"
RHEA:49532	skos:altLabel	"MHETase"
RHEA:49532	skos:prefLabel	"mono(ethylene terephthalate) hydrolase"
RHEA:49532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mono(ethylene terephthalate) hydrolase"
RHEA:49532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = ethylene glycol + H(+) + terephthalate
REACT:R-RNO-4641129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is ubiquitinated by SMURF2 (Rattus norvegicus)
RHEA:31919	skos:altLabel	"CYP71C2"
RHEA:31919	skos:prefLabel	"indolin-2-one monooxygenase"
RHEA:31919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:31919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indolin-2-one monooxygenase"
REACT:R-SPO-351215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Schizosaccharomyces pombe)
REACT:R-DME-3322041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Drosophila melanogaster)
RHEA:48629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ribonucleotide in rRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-CEL-8944457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAF1 translocates to the nucleus (Caenorhabditis elegans)
EC:3.2.1.127	skos:prefLabel	"1,6-alpha-L-fucosidase"
EC:3.2.1.127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1,6-alpha-L-fucosidase"
REACT:R-RNO-5626962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNB2L1 binds IKKA:IKKB:NEMO (Rattus norvegicus)
REACT:R-BTA-3662318	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type B histone acetlytransferase complex acetylates histone H4 (Bos taurus)
REACT:R-DRE-75010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser 216 by Chk1 (Danio rerio)
REACT:R-DRE-2730856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK (Danio rerio)
RHEA:70213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose => 2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose
RHEA:54374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-(2S,3R,9R)-pristinol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O
RHEA:68234	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(out) + Na(+)(out) => L-cysteine(in) + Na(+)(in)
REACT:R-GGA-9018778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds interacting proteins at the endosome membrane (Gallus gallus)
GO:0018483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	6-oxohexanoate:NADP+ oxidoreductase activity
GO:0018483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-oxohexanoate dehydrogenase activity
REACT:R-HSA-9708327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANG cleaves tRNA to yield tRNA halves (Homo sapiens)
REACT:R-RNO-9750226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRC5 binds IKBKB and CHUK (Rattus norvegicus)
REACT:R-HSA-1482778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL is hydrolyzed to MLCL by PLA2G6 (IM) (Homo sapiens)
REACT:R-RNO-5626469	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP-bound RAC1 and CDC42 bind IQGAPs (Rattus norvegicus)
RHEA:20489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)
RHEA:20489	skos:prefLabel	"alanylphosphatidylglycerol synthase"
RHEA:20489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alanylphosphatidylglycerol synthase"
RHEA:44738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2,4-dioxopentyl phosphate + CoA => acetyl-CoA + dihydroxyacetone phosphate
RHEA:64992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine
RHEA:10824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate + NADP(+) = H(+) + NADPH + oxaloacetate
REACT:R-RNO-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Rattus norvegicus)
REACT:R-CEL-5334794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FABPs bind LCFAs (Caenorhabditis elegans)
RHEA:22618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2R)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin
GO:0008707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phytate 6-phosphatase activity
GO:0008707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-phytase activity
GO:0008707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-phytase activity
GO:0008707	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myo-inositol-hexakisphosphate 6-phosphohydrolase activity
GO:0008707	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phytase activity
GO:0008707	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	6-phytase (name based on 1L-numbering system and not 1D-numbering)
RHEA:39225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octacosenoyl-CoA + H2O => (3R)-hydroxyoctacosanoyl-CoA
RHEA:52093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)
GO:0031707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endothelin-1 receptor binding
GO:0031707	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	endothelin A receptor ligand
GO:0031707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	endothelin A receptor binding
GO:0036131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin D2 11-ketoreductase activity
GO:0036131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGD2 11-ketoreductase
GO:0036131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin 11-keto reductase
REACT:R-CEL-9011543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCA binds PDK2 (Caenorhabditis elegans)
REACT:R-GGA-446684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Gallus gallus)
RHEA:72890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] <=> ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:59258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => Fe(III)-enterobactin + H2O
RHEA:60613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octanoyl-sn-glycero-3-phosphocholine => 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline
REACT:R-HSA-879937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The common beta chain IL3RB binds JAK2 (Homo sapiens)
REACT:R-BTA-4090288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,3 SUMOylate MBD1 with SUMO1 (Bos taurus)
REACT:R-BTA-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Bos taurus)
RHEA:52379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) <=> (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)
REACT:R-CFA-70581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)
RHEA:64202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + L-leucine => an N-(fatty acyl)-L-leucine + H2O
RHEA:49197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]
RHEA:61683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-cysteine <=> AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]
GO:0008523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium-dependent multivitamin transmembrane transporter activity
REACT:R-MMU-888548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH5A1 dehydrogenates SUCCSA to SUCCA (Mus musculus)
REACT:R-MMU-109702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates AKT2 (Mus musculus)
REACT:R-BTA-3299753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Bos taurus)
REACT:R-HSA-6801462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Homo sapiens)
GO:0016616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycolate reductase
GO:0016616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11 reduces RBP2:atRAL to RBP2:atROL (Homo sapiens)
GO:0016616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyoxylic acid reductase
GO:0016616	skos:prefLabel	"With NAD(+) or NADP(+) as acceptor"
GO:0016616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With NAD(+) or NADP(+) as acceptor"
GO:0016616	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-dependent glyoxylate reductase
GO:0045483	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	sesquiterpene cyclase activity
GO:0045483	skos:altLabel	"trans,trans-farnesyl diphosphate aristolochene-lyase"
GO:0045483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)
GO:0045483	skos:prefLabel	"aristolochene synthase"
GO:0045483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aristolochene synthase activity
GO:0045483	skos:altLabel	"sesquiterpene cyclase"
GO:0045483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate
GO:0045483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trans,trans-farnesyl diphosphate aristolochene-lyase activity
GO:0045483	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)
GO:0045483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aristolochene synthase"
GO:0045134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphatase activity
GO:0045134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP phosphatase activity
GO:0045134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine-diphosphatase activity
GO:0045134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPase activity
GO:0045134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP phosphohydrolase activity
GO:0045134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine 5'-diphosphatase activity
RHEA:50615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanal + NADP(+) <=> (2E)-decenal + H(+) + NADPH
REACT:R-HSA-9645501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Homo sapiens)
REACT:R-RNO-1676177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)
RHEA:70467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate
REACT:R-HSA-389980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	unfolded actin/tubulin associates with prefoldin (Homo sapiens)
RHEA:24171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RHEA:60329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine
REACT:R-CFA-163120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Telomerase RNP and the Chromosome End (Canis familiaris)
REACT:R-MMU-2046085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Mus musculus)
REACT:R-RNO-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Rattus norvegicus)
REACT:R-SSC-9707977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Sus scrofa)
RHEA:69013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrotestosterone + H(+) + NADPH => 5beta-androstane-3beta,17beta-diol + NADP(+)
REACT:R-XTR-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Xenopus tropicalis)
REACT:R-DRE-177924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Gab1 by SHP2 (Danio rerio)
RHEA:49636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methylglyoxal + O2 = H(+) + H2O2 + pyruvate
RHEA:22158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + H(+) + phosphate => GDP + H2O
REACT:R-CFA-73918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Canis familiaris)
REACT:R-XTR-8952371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds RUNX3 (Xenopus tropicalis)
GO:0032977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	membrane insertase activity
GO:0032001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-glucan 6-alpha-glucosyltransferase activity
GO:0032001	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	T-enzyme
GO:0032001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity
GO:0032001	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	oligoglucan-branching glycosyltransferase activity
GO:0032001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity
GO:0032001	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	D-glucosyltransferase
REACT:R-HSA-9690494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOB translocates to the endosome membrane (Homo sapiens)
REACT:R-SSC-1168633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NF-kappaB translocates from the cytosol to the nucleus (Sus scrofa)
RHEA:23246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + norspermidine + S-methyl-5'-thioadenosine => propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine
RHEA:48306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose
RHEA:38057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP + H(+) + phytyl phosphate => CTP + phytol
RHEA:16967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-myrcene + diphosphate => (2E)-geranyl diphosphate
RHEA:40463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)
RHEA:20371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + H(+) + H2O2 => betaine aldehyde + H2O + O2
GO:0015350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methotrexate transmembrane transporter activity
GO:0015350	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	methotrexate transporter activity
REACT:R-MMU-6807877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity (Mus musculus)
REACT:R-RNO-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Rattus norvegicus)
RHEA:20898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + urea-1-carboxylate => ATP + hydrogencarbonate + urea
REACT:R-RNO-5654679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates FRS2 and FGFR3 (Rattus norvegicus)
REACT:R-BTA-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Bos taurus)
RHEA:13761	skos:prefLabel	"methionine S-methyltransferase"
RHEA:13761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methionine S-methyltransferase"
RHEA:13761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine
RHEA:57133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ascorbate + O2 + tyramine => (R)-octopamine + H2O + L-dehydroascorbate
GO:0140432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-hydroxyl dinucleotide hydrolase
RHEA:16019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-ornithine
RHEA:24369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-ornithine => L-proline + NH4(+)
REACT:R-SSC-5674387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MAPKs translocate into the nucleus (Sus scrofa)
REACT:R-RNO-5617178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2B4 binds to NOS1, inhibiting it (Rattus norvegicus)
EC:1.14.14.85	skos:altLabel	"CYP72A224"
EC:1.14.14.85	skos:prefLabel	"7-deoxyloganate 7-hydroxylase"
EC:1.14.14.85	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-deoxyloganate 7-hydroxylase"
EC:1.14.14.85	skos:altLabel	"7-deoxyloganin 7-hydroxylase"
REACT:R-GGA-8875183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL monoubiquitinates activated MET (Gallus gallus)
REACT:R-SCE-1676105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)
GO:0043904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IPL
GO:0043904	skos:prefLabel	"isochorismate lyase"
GO:0043904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isochorismate lyase"
GO:0043904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochorismate pyruvate lyase activity
GO:0043904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochorismate-pyruvate lyase activity
GO:0043904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isochorismate = pyruvate + salicylate
GO:0043904	skos:altLabel	"isochorismate pyruvate lyase"
REACT:R-SSC-399951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CRMPs by GSK3beta (Sus scrofa)
REACT:R-DRE-349593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaIIbbeta3 with Fibronectin (Danio rerio)
RHEA:15090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lactate + A => AH2 + pyruvate
RHEA:17076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + cortisol <=> CoA + cortisol 21-acetate
REACT:R-HSA-4395231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1/3:DP1/2 binds NOTCH1 promoter (Homo sapiens)
REACT:R-DRE-8951656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-UBA3:NAE1 binds a second NEDD8 (Danio rerio)
RHEA:53894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a prenal + H2O2 + L-cysteine => an S-prenyl-L-cysteine + H2O + O2
RHEA:42209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 => a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)
RHEA:11255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydroxylamine + L-asparagine <=> beta-L-aspartylhydroxamate + NH4(+)
RHEA:14338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate => adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate
REACT:R-DME-8868658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
REACT:R-SPO-4167511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HLCS biotinylates ACACB (Schizosaccharomyces pombe)
EC:3.1.21.3	skos:altLabel	"type I restriction enzyme"
EC:3.1.21.3	skos:prefLabel	"type I site-specific deoxyribonuclease"
EC:3.1.21.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"type I site-specific deoxyribonuclease"
REACT:R-HSA-204364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO1 binds SLIT2 (Homo sapiens)
REACT:R-MMU-481044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Surface deployment of platelet alpha granule membrane components (Mus musculus)
RHEA:35574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:56312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate
REACT:R-CFA-934559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPRY2 is phosphorylated by phosphorylated MNK1 (Canis familiaris)
RHEA:66373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 3-phosphate => glycerol + phosphate
REACT:R-RNO-200410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Rattus norvegicus)
RHEA:67459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine
REACT:R-XTR-8870332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Xenopus tropicalis)
REACT:R-DRE-5692764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 binds CCND3 (Danio rerio)
RHEA:22527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + a carotenoid beta-end derivative <=> a carotenoid phi-end derivative + 2 AH2
REACT:R-MMU-212222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRC2 recruits DNA methyltransferases (Mus musculus)
RHEA:47682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tagatopyranose 1-phosphate + NH4(+) => D-galactosamine 6-phosphate + H2O
RHEA:53198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone
RHEA:39087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanedioyl-CoA + O2 = (2E)-decenedioyl-CoA + H2O2
RHEA:29128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a menaquinol + nitrate => a menaquinone + H2O + nitrite
REACT:R-MMU-139899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sequestration of BAD protein by 14-3-3 (Mus musculus)
GO:0004412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homoserine dehydrogenase activity
GO:0005335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium/serotonin symporter activity
GO:0005335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + Na(+)(out) + serotonin(out) = chloride(in) + Na(+)(in) + serotonin(in)
GO:0005335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serotonin transmembrane transporter activity
GO:0005335	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	serotonin:sodium:chloride symporter activity
GO:0005335	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	serotonin:sodium symporter activity
REACT:R-DRE-6791222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Danio rerio)
EC:3.4.23.41	skos:altLabel	"aspartic proteinase 3"
EC:3.4.23.41	skos:prefLabel	"yapsin 1"
EC:3.4.23.41	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"yapsin 1"
EC:3.4.23.41	skos:altLabel	"yeast aspartic protease 3"
RHEA:40129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-MMU-200406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CPT1A,B transfers PALM to CAR (Mus musculus)
GO:0034543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminosalicylate dioxygenase activity
REACT:R-RNO-6805276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK5 phosphorylates TP53 (Rattus norvegicus)
REACT:R-SSC-1475026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (cytosol) (Sus scrofa)
REACT:R-HSA-6804188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDM1 represses TP53 expression (Homo sapiens)
RHEA:72675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic CMP + H2O = CMP + H(+)
RHEA:57206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glyoxal + L-lysyl-[protein]
RHEA:30575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 menaquinone-8 + protoporphyrinogen IX = 3 menaquinol-8 + protoporphyrin IX
REACT:R-BTA-1364044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR:JAK2 dimerizes (Bos taurus)
RHEA:71572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-(L-seryl)-dTMP in DNA + H(+) => 5-aminoethoxy-methyl-dUMP in DNA + CO2
GO:0052717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA(Ala)-A34 deaminase activity
GO:0052717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA-specific adenosine-34 deaminase activity
REACT:R-RNO-9613213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Rattus norvegicus)
REACT:R-DRE-4641159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is ubiquitinated by HECW1 (Danio rerio)
GO:0043824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AstD
GO:0043824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SGSD
GO:0043824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinylglutamic semialdehyde dehydrogenase activity
GO:0043824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinyl glutamate-semialdehyde dehydrogenase activity
GO:0043824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AruD
GO:0043824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	succinylglutamate-semialdehyde dehydrogenase activity
GO:0043824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity
GO:0043824	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-succinylglutamate 5-semialdehyde dehydrogenase activity
REACT:R-GGA-5623632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Gallus gallus)
RHEA:37379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-DRE-1250315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB4 homodimers (Danio rerio)
REACT:R-BTA-3262512	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) (Bos taurus)
REACT:R-DRE-351963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A18 transports Gly from extracellular region to cytosol (Danio rerio)
REACT:R-RNO-2046180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KSPG is secreted from the cell (Rattus norvegicus)
REACT:R-SCE-8868066	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Saccharomyces cerevisiae)
REACT:R-XTR-3076905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extracellular BTD hydrolyses BCTN (Xenopus tropicalis)
GO:0008353	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA polymerase subunit kinase activity
GO:0008353	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNA-polymerase-subunit kinase activity
GO:0008353	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	[RNA-polymerase]-subunit kinase activity
GO:0008353	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	CTD kinase activity
GO:0008353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II carboxy-terminal domain kinase activity
GO:0008353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II CTD heptapeptide repeat kinase activity
REACT:R-DDI-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Dictyostelium discoideum)
REACT:R-MMU-5654647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
REACT:R-RNO-9698844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLKL binds HSP90:CDC37 (Rattus norvegicus)
RHEA:23808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-scoulerine 9-O-methyltransferase"
RHEA:23808	skos:prefLabel	"(S)-scoulerine 9-O-methyltransferase"
RHEA:23808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-scoulerine + S-adenosyl-L-methionine = (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-9734070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anti-MET recombinant therapeutic antibodies bind MET (Homo sapiens)
RHEA:25963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoin + NADP(+) <=> benzil + H(+) + NADPH
REACT:R-HSA-9026777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)
REACT:R-CFA-8937613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRHBP binds CRH (Canis familiaris)
REACT:R-CFA-110248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 3-methyladenine by MPG glycosylase  (Canis familiaris)
REACT:R-MMU-6808464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3B2 oxidises HXAL to PALM (Mus musculus)
REACT:R-MMU-8869568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPM1 binds TFAP2A homodimer (Mus musculus)
REACT:R-HSA-9625409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KLF4 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
RHEA:21502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-alpha-D-glucose
GO:0044596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-demethylubiquinol-10 3-O-methyltransferase activity
REACT:R-CFA-8938300	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vanin hydrolyses pantetheine to PanK, 2AET (Canis familiaris)
REACT:R-GGA-2129357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin C-terminal processing (Gallus gallus)
REACT:R-RNO-198714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 translocates to the nucleus (Rattus norvegicus)
REACT:R-HSA-8983373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-STAT3 binds p-STAT5 (Homo sapiens)
REACT:R-GGA-380311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Plk1 to centrosomes (Gallus gallus)
REACT:R-DRE-2089971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Secretion of collagens (Danio rerio)
REACT:R-SSC-5218814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 autophorylates (Sus scrofa)
REACT:R-CFA-5668718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX1 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)
REACT:R-CFA-5654697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
RHEA:67104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + fumigatonoid C + O2 = CO2 + H2O + novofumigatonin + succinate
REACT:R-RNO-8875558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAPGEF1 binds CRK,CRKL (Rattus norvegicus)
REACT:R-GGA-204873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shp2 (Gallus gallus)
REACT:R-HSA-1218824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 is inactivated by binding to benzaquinoid ansamycins (Homo sapiens)
RHEA:45777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(indol-3-yl)acetonitrile + 2 H2O => (indol-3-yl)acetate + NH4(+)
RHEA:24054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] => a ubiquinone + reduced [electron-transfer flavoprotein]
REACT:R-CFA-6805620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A and PML bind TP53 (Canis familiaris)
RHEA:46556	skos:altLabel	"Delta(7)-sterol Delta(5)-dehydrogenase"
RHEA:46556	skos:altLabel	"Delta(7)-sterol-C5(6)-desaturase"
RHEA:46556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Delta(7)-sterol 5(6)-desaturase"
RHEA:46556	skos:altLabel	"lathosterol oxidase"
RHEA:46556	skos:altLabel	"Delta(7)-sterol 5-desaturase"
RHEA:46556	skos:altLabel	"lathosterol 5-desaturase"
RHEA:46556	skos:altLabel	"5-DES"
RHEA:46556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 = 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:46556	skos:prefLabel	"Delta(7)-sterol 5(6)-desaturase"
RHEA:28901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(out) + H(+)(out) => glycine(in) + H(+)(in)
REACT:R-DRE-6787540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUK phosphorylates beta-Fuc to Fuc1P (Danio rerio)
RHEA:62423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (R)-2-hydroxy fatty acid + O2 <=> a fatty acid + CO2 + H2O
REACT:R-DRE-430347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MigFilin associates with Filamin and F-actin (Danio rerio)
GO:0033808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6'-deoxychalcone synthase activity
GO:0033808	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity
GO:0033808	skos:prefLabel	"6'-deoxychalcone synthase"
GO:0033808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)
GO:0033808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6'-deoxychalcone synthase"
RHEA:24801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate
REACT:R-CFA-9731931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA binds selective ERAs (Canis familiaris)
REACT:R-GGA-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Gallus gallus)
REACT:R-SSC-112381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Sus scrofa)
RHEA:16062	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sn-glycerol 3-phosphocholine => choline + H(+) + sn-glycerol 3-phosphate
RHEA:16875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA
RHEA:33794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sucrose 6(F)-phosphate <=> beta-D-fructose + beta-D-glucose 6-phosphate
REACT:R-CFA-201608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of alpha adducin (Canis familiaris)
RHEA:63377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-SSC-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Sus scrofa)
RHEA:37352	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine 2'-phosphate + H2O => cytidine + phosphate
RHEA:11836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
RHEA:71645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide => guanosine + NAD(+)
RHEA:60974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hexanal + NADH => hexan-1-ol + NAD(+)
GO:0005052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisome matrix targeting signal-1 binding
GO:0005052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTS1 binding
GO:0005052	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PEX5
GO:0005052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisomal targeting signal 1 (PTS1) binding
GO:0005052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peroxisome targeting signal-1 binding
GO:0005052	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	PTS1 receptor
GO:0005052	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	peroxisome targeting signal-1 receptor
REACT:R-DDI-9013869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX41 binds bacterial c-di-AMP, c-di-GMP   (Dictyostelium discoideum)
RHEA:35094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine <=> 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine
RHEA:64800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + S-(2-aminoethyl)-L-cysteine = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)
EC:1.1.3.5	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hexose oxidase"
EC:1.1.3.5	skos:prefLabel	"hexose oxidase"
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen synthase D phosphatase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen synthetase phosphatase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen-synthase-D phosphatase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen synthase phosphatase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatase type 2oC
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Mg2+ dependent glycogen synthase phosphatase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glycogen glucosyltransferase phosphatase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[glycogen-synthase-D] phosphatase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycogen glucosyltransferase phosphatase activity
GO:0050407	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose-glycogen glucosyltransferase phosphatase activity
REACT:R-SCE-482621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Saccharomyces cerevisiae)
GO:0008976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyphosphate polymerase activity
GO:0008976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyphosphate kinase activity
GO:0008976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:polyphosphate phosphotransferase activity
GO:0008976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-polyphosphate phosphotransferase activity
GO:0008976	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	polyphosphoric acid kinase activity
GO:0106258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline
GO:0106258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-serine-phosphatidylcholine phosphatidyltransferase activity
GO:0102903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"gamma-terpinene synthase"
GO:0102903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate = diphosphate + gamma-terpinene
GO:0102903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-terpinene synthase activity
GO:0102903	skos:prefLabel	"gamma-terpinene synthase"
REACT:R-MMU-9731228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)
REACT:R-HSA-9630921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKBIA variant binds NFkB complex (Homo sapiens)
REACT:R-RNO-9748949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUK1 phosphorylates 6TGMP to 6TGDP (Rattus norvegicus)
REACT:R-CFA-2002466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of allysine by LOX (Canis familiaris)
RHEA:57628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate = H2O + ML-236C carboxylate
RHEA:17786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-glutamate => 4-aminobutanoate + CO2
GO:0047298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity
GO:0047298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity
GO:0047298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-AIBAT activity
GO:0047298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-2-methylpropionate aminotransferase activity
GO:0047298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-aminoisobutyrate transaminase activity
GO:0047298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-aminoisobutyric aminotransferase activity
GO:0047298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-amino-2-methylpropionate transaminase activity
GO:0047298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-aminobutyric transaminase activity
GO:0047298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-3-aminoisobutyrate aminotransferase activity
REACT:R-GGA-4615900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB2 with SUMO3 (Gallus gallus)
RHEA:35320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + malonyl-CoA + octadecanoyl-CoA => 3-oxoeicosanoyl-CoA + CO2 + CoA
RHEA:58666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a quinol => (S)-2-hydroxyglutarate + a quinone
RHEA:36371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hydroxybutanoate + NAD(+) = 2-oxobutanoate + H(+) + NADH
REACT:R-MMU-74242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Mus musculus)
REACT:R-XTR-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Xenopus tropicalis)
REACT:R-HSA-381135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)
RHEA:24867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2
REACT:R-BTA-5654399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS2 (Bos taurus)
REACT:R-RNO-389897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Rattus norvegicus)
REACT:R-XTR-75125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Xenopus tropicalis)
REACT:R-CEL-1614567	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excess homocysteine yields homolanthionine and H2S (Caenorhabditis elegans)
RHEA:64467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[protein] + 2 O2 <=> H(+) + H2O2 + L-topaquinyl-[protein]
RHEA:58685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + 2 H(+) + NADPH + O2 => FADH2-C4alpha-hydroperoxide + NADP(+)
RHEA:57895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + 5 H(+)(in) + NADPH <=> a quinol + 4 H(+)(out) + NADP(+)
REACT:R-XTR-2028670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Xenopus tropicalis)
REACT:R-RNO-5228523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates MDM2 with SUMO1 (Rattus norvegicus)
REACT:R-HSA-9664332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREB1 binds IL-10 promoter (Homo sapiens)
REACT:R-DME-170126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cyclin B1 in the CRS domain (Drosophila melanogaster)
REACT:R-SSC-8986994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Sus scrofa)
REACT:R-XTR-209960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diiodinated tyrosine can be deiodinated (Xenopus tropicalis)
RHEA:45899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acyl-sphingoid base + CDP-ethanolamine <=> an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)
REACT:R-DRE-5607723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Danio rerio)
GO:0005000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vasopressin receptor activity
GO:0005000	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	vasopressin activated calcium mobilizing receptor activity
RHEA:61120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-DRE-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Danio rerio)
REACT:R-MMU-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Mus musculus)
RHEA:70240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside
RHEA:41776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) = CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)
RHEA:52309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH
RHEA:68958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + S-adenosyl-L-homocysteine + scoparone => S-adenosyl-L-methionine + scopoletin
REACT:R-MMU-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Mus musculus)
REACT:R-DRE-420598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-1:Nectin-4 trans heterodimer formation (Danio rerio)
RHEA:29323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fumarate(in) + succinate(out) = fumarate(out) + succinate(in)
REACT:R-DME-350436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DGO binds to DSH (Drosophila melanogaster)
RHEA:56081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[Rab1 protein]-L-serine + CDP-choline => [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)
RHEA:57696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(I)inamide-[corrinoid adenosyltransferase] = adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate
RHEA:43572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + D-arginine + H2O = 5-guanidino-2-oxopentanoate + AH2 + NH4(+)
RHEA:43572	skos:prefLabel	"D-arginine dehydrogenase"
RHEA:43572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-arginine dehydrogenase"
RHEA:43572	skos:altLabel	"D-amino-acid dehydrogenase"
EC:1.11.1.10	skos:altLabel	"chloroperoxidase"
EC:1.11.1.10	skos:altLabel	"CPO"
EC:1.11.1.10	skos:prefLabel	"chloride peroxidase"
EC:1.11.1.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"chloride peroxidase"
EC:1.11.1.10	skos:altLabel	"vanadium haloperoxidase"
REACT:R-CFA-8852127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)
REACT:R-SSC-73920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Sus scrofa)
RHEA:58535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-stemmadenine intermediate I + H2O <=> akuammicine + formate + H(+)
REACT:R-RNO-170847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
RHEA:35272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
RHEA:16195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O
GO:0015099	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
GO:0015099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ni(2+)(in) = Ni(2+)(out)
GO:0015099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nickel cation transmembrane transporter activity
GO:0031832	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 6 serotonin receptor ligand
GO:0031832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxytryptamine 6 receptor binding
GO:0031832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 6 serotonin receptor binding
REACT:R-HSA-1676082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
RHEA:71337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + L-tryptophan(in) + 2 Na(+)(in) => chloride(out) + L-tryptophan(out) + 2 Na(+)(out)
REACT:R-DRE-5690873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACO1 binds 4Fe-4S (Danio rerio)
REACT:R-CEL-1483063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG and CDP-DAG are converted to CL by CRLS1 (Caenorhabditis elegans)
RHEA:34014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydroepisterol + 2 H2O + NADP(+) <=> ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2
REACT:R-DRE-5666216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP:RTKN binds TAX1BP3 (Danio rerio)
RHEA:19752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP
RHEA:19116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-heptadecatrienal + A + H2O <=> (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)
REACT:R-DME-8875623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Drosophila melanogaster)
GO:0102715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A17,oxoglutarate:oxygen oxidoreductase activity
REACT:R-CEL-5672008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thr-180 of ULK1 is phosphorylated (Caenorhabditis elegans)
RHEA:42797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + cholesterol => cholesteryl (9Z,12Z)-octadecadienoate + CoA
RHEA:61951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate
REACT:R-DME-975903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Drosophila melanogaster)
REACT:R-MMU-114263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization  of BAK at the mitochondrial membrane (Mus musculus)
RHEA:58883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
REACT:R-DME-170044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Drosophila melanogaster)
RHEA:25701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N,N-dihydroxy-L-hexahomomethionine <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O
RHEA:15001	skos:prefLabel	"sorbose 5-dehydrogenase (NADP(+))"
RHEA:15001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sorbose 5-dehydrogenase (NADP(+))"
RHEA:15001	skos:altLabel	"5-ketofructose reductase"
RHEA:15001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH
REACT:R-RNO-5691176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Rattus norvegicus)
REACT:R-SSC-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Sus scrofa)
RHEA:60127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-sodorifen diphosphate <=> diphosphate + sodorifen
REACT:R-CEL-6814120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Caenorhabditis elegans)
REACT:R-CFA-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Canis familiaris)
REACT:R-HSA-5663265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors (Homo sapiens)
RHEA:52922	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate
RHEA:43117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine
RHEA:70258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine
REACT:R-RNO-74207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Rattus norvegicus)
REACT:R-DRE-111883	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of phosphatidylcholine (Danio rerio)
RHEA:68384	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] = (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate
RHEA:18407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + NH4(+) + pyruvate => H2O + L-alanine + NAD(+)
GO:0050462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminic acid synthase activity
GO:0050462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylneuraminate synthase activity
GO:0050462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity
GO:0050462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
GO:0050462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(NANA)condensing enzyme activity
GO:0050462	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NeuAc synthase activity
REACT:R-RNO-9027624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DHA to 7-HDHA (Rattus norvegicus)
REACT:R-CFA-9758604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
RHEA:23396	skos:altLabel	"C-acylphenol hydrolase"
RHEA:23396	skos:prefLabel	"phloretin hydrolase"
RHEA:23396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phloretin hydrolase"
RHEA:23396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phloretin = 1,3,5-trihydroxybenzene + H(+) + phloretate
RHEA:11814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formaldehyde + H(+) + H2O2 + hydrogen sulfide => H2O + methanethiol + O2
RHEA:57710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP => (E)-coniferaldehyde + UDP-alpha-D-glucose
RHEA:43048	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keto-D-tagatose = keto-D-sorbose
REACT:R-MMU-113402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DSIF:NELF:early elongation complex (Mus musculus)
RHEA:35286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA <=> (2E)-octadecenoyl-CoA
REACT:R-DME-162873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)
RHEA:14067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => scyllo-inosose
RHEA:66917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-BTA-209960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Diiodinated tyrosine can be deiodinated (Bos taurus)
REACT:R-DDI-9753284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Dictyostelium discoideum)
GO:0042302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of cuticle
REACT:R-DME-8951727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP binds PKA tetramer (Drosophila melanogaster)
REACT:R-GGA-9017491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GEFs activate RHOJ (Gallus gallus)
RHEA:70063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-4568914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of BLM with SUMO2,3 (Xenopus tropicalis)
REACT:R-RNO-1679098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Rattus norvegicus)
RHEA:15886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + propane-1,2-diol => (S)-lactaldehyde + H(+) + NADPH
REACT:R-CEL-9635743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN7 binds p-T,Y-MAPK (Caenorhabditis elegans)
REACT:R-CEL-1535903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Caenorhabditis elegans)
REACT:R-SSC-5690043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)
RHEA:33127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + salicin-6-phosphate = beta-D-glucose 6-phosphate + salicyl alcohol
RHEA:68197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexanoylglycerol + tetradecanoyl-CoA => 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA
RHEA:14178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-amygdalin + H2O => (R)-prunasin + D-glucose
REACT:R-SSC-209925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DIT and MIT combine to form triiodothyronine (Sus scrofa)
RHEA:71394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)
RHEA:16204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-4-deoxychorismate <=> 4-aminobenzoate + H(+) + pyruvate
REACT:R-SPO-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Schizosaccharomyces pombe)
REACT:R-XTR-6789136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myeloperoxidase (MPO) binds to the bacterial cell surface (Xenopus tropicalis)
RHEA:32292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoethanolamine + 3 S-adenosyl-L-methionine => 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine
RHEA:48321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GA1 + GDP-beta-L-fucose => ganglioside Fuc-GA1 + GDP + H(+)
REACT:R-RNO-1013012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)
REACT:R-SCE-73608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Saccharomyces cerevisiae)
RHEA:14649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"demethyllactenocin mycarosyltransferase"
RHEA:14649	skos:prefLabel	"demethyllactenocin mycarosyltransferase"
RHEA:14649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	demethyllactenocin + dTDP-beta-L-mycarose = demethylmacrocin + dTDP + H(+)
GO:0070338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-flap-structured DNA binding
REACT:R-CEL-8982018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Caenorhabditis elegans)
REACT:R-HSA-9693929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK1 variant is not cleaved by CASP8 (Homo sapiens)
RHEA:45743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ectoine + O2 <=> 5-hydroxyectoine + CO2 + succinate
REACT:R-DME-450092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Drosophila melanogaster)
REACT:R-RNO-71296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Rattus norvegicus)
REACT:R-HSA-2130619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGN-lysosomal vesicle coat assembly (Homo sapiens)
REACT:R-GGA-4793911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPKAPK2 phosphorylates HSF1 (Gallus gallus)
REACT:R-RNO-74712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of IRS-P from insulin receptor (Rattus norvegicus)
REACT:R-HSA-9701525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y705,S727-STAT3 dimerizes (Homo sapiens)
REACT:R-MMU-9624112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK4 (Mus musculus)
GO:0015288	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	outer membrane exporter porin
GO:0015288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	porin
GO:0015288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	porin activity
RHEA:69621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-HSA-211650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK-2p34 in the activation loop (Homo sapiens)
REACT:R-MMU-8876868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ECE1 cleaves EDN1(53-90) (Mus musculus)
REACT:R-HSA-6803801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 in complex with ZNF385A binds the CDKN1A promoter (Homo sapiens)
REACT:R-XTR-210881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of Tie2/Ang1 complex (Xenopus tropicalis)
RHEA:43703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesoate + S-adenosyl-L-methionine <=> methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine
RHEA:20054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + ribitol => D-ribulose + H(+) + NADH
REACT:R-CFA-6804383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT5 methylates TP53 (Canis familiaris)
REACT:R-CEL-9757258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Caenorhabditis elegans)
REACT:R-CFA-70893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Canis familiaris)
RHEA:13955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a D-alpha-amino acid + a tRNA + H(+) => a D-aminoacyl-tRNA + H2O
RHEA:38943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate
REACT:R-SSC-2160492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4I1:FAD oxidises L-Phe to kPPV (Sus scrofa)
REACT:R-SSC-9734730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 translocates to the nucleus (Sus scrofa)
REACT:R-GGA-9009309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STUB1 (Gallus gallus)
REACT:R-DME-8959781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Drosophila melanogaster)
RHEA:57877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(54) in tRNA => pseudouridine(54) in tRNA
REACT:R-HSA-163750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
RHEA:55876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[aequorin] + coelenterazine = apo-[aequorin]--coelenterazine
RHEA:13173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphonate dehydrogenase"
RHEA:13173	skos:altLabel	"phosphite dehydrogenase"
RHEA:13173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + phosphonate = H(+) + NADH + phosphate
RHEA:13173	skos:altLabel	"NAD:phosphite oxidoreductase"
RHEA:13173	skos:prefLabel	"phosphonate dehydrogenase"
RHEA:13173	skos:altLabel	"NAD-dependent phosphite dehydrogenas"
GO:0031856	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	parathyroid hormone receptor ligand
GO:0031856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	parathyroid hormone receptor binding
REACT:R-MMU-176669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Mus musculus)
REACT:R-DRE-266299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Spherical HDL binds membrane-associated free cholesterol and phospholipids (Danio rerio)
RHEA:36579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-alpha-D-fucose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH
RHEA:17371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate => glycyrrhizin + H2O
REACT:R-XTR-8868118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK12 phosphorylates PTPN3 (Xenopus tropicalis)
RHEA:29530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
GO:0050575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(S)-hydroxypropyl-CoM dehydrogenase activity
GO:0050575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity
GO:0050575	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity
REACT:R-SPO-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Schizosaccharomyces pombe)
REACT:R-CFA-444647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C3a receptor binds anaphylatoxin C3a (Canis familiaris)
REACT:R-BTA-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Bos taurus)
RHEA:63236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + streptomycin = 6-O-adenylylstreptomycin + diphosphate
RHEA:19655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+)
RHEA:64051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphinganine
RHEA:45045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 => 2 Fe(III)-[cytochrome c] + H2O + nitrite
REACT:R-DRE-549297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Danio rerio)
REACT:R-DME-8941623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)
REACT:R-RNO-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Rattus norvegicus)
REACT:R-RNO-141159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)
REACT:R-XTR-73920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Xenopus tropicalis)
RHEA:18997	skos:altLabel	"CTP:phosphocholine cytidylyltransferase"
RHEA:18997	skos:altLabel	"phosphorylcholine transferase"
RHEA:18997	skos:prefLabel	"choline-phosphate cytidylyltransferase"
RHEA:18997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"choline-phosphate cytidylyltransferase"
RHEA:18997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + phosphocholine = CDP-choline + diphosphate
REACT:R-SSC-194674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Sus scrofa)
REACT:R-MMU-450466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1:mRNA complex is destroyed (Mus musculus)
RHEA:48731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH
GO:0003862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-isopropylmalate dehydrogenase activity
GO:0003862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-isopropylmalate dehydrogenase activity
GO:0003862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IMDH activity
GO:0003862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity
GO:0003862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IPMDH
GO:0003862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-isopropylmalic enzyme
GO:0003862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-IPM dehydrogenase activity
GO:0003862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	threo-Ds-3-isopropylmalate dehydrogenase activity
GO:0003862	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity
REACT:R-BTA-9638064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Bos taurus)
REACT:R-SCE-888614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDO2 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)
REACT:R-RNO-6798751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of azurophil granule lumen proteins (Rattus norvegicus)
REACT:R-CFA-352136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Canis familiaris)
RHEA:56406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+) => [(3R)-hydroxybutanoate](n) + H2O
RHEA:71489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanyl-L-leucine + L-tyrosylglycylglycine => H2O + Leu-enkephalin
REACT:R-XTR-8855131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9 binds Clathrin-coated vesicles (Xenopus tropicalis)
REACT:R-MMU-5693356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEMIP hydrolyses HA (Mus musculus)
RHEA:44301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA => 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA
RHEA:50718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate => dimethyl sulfone + FMNH2 + O2
REACT:R-CFA-159757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)
REACT:R-CFA-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Canis familiaris)
RHEA:65271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxypentacecilide A + H(+) + NADPH + O2 <=> chrodrimanin F + H2O + NADP(+)
REACT:R-PFA-532549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPI isomerises Fru6P to Man6P (Plasmodium falciparum)
RHEA:44530	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O
GO:0140817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone H3-S10 serine ADP-ribosyltransferase activity
GO:0140817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone-serine ADP-ribosyltransferase activity (H3-S10 specific)
GO:0140817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD+-histone H3S10 serine ADP-ribosyltransferase activity
RHEA:34724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine 1-phosphate + H2O => 15-methylhexadecasphing-4-enine + phosphate
RHEA:26051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-2029471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hydrolysis of PC to PA by PLD (Caenorhabditis elegans)
RHEA:31712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-HSA-2168888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alpha1-Microglobulin binds heme (Homo sapiens)
REACT:R-DRE-419428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR2-5 bind S1P (Danio rerio)
REACT:R-HSA-8869633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK1 phosphorylates NR to yield NMN (Homo sapiens)
REACT:R-CEL-5679239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK complex translocates to the ER (Caenorhabditis elegans)
RHEA:27936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + glyoxylate => (3S)-3-hydroxy-D-aspartate
GO:0140035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ubiquitination-like modification-dependent protein binding
REACT:R-MMU-561059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OAT2 and OAT4 mediate transport of sulphate conjugates (Mus musculus)
REACT:R-XTR-9656893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1MW binds 11cRAL (Xenopus tropicalis)
REACT:R-BTA-396996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs binds G-protein Gq (Bos taurus)
REACT:R-GGA-8981892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active G alpha (z) binds RGS proteins (Gallus gallus)
GO:0018504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-benzene glycol dehydrogenase activity
GO:0018504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0018504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity
GO:0018504	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity
GO:0005275	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	amine/amide/polyamine channel activity
GO:0005275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amino acid-polyamine transmembrane transporter activity
GO:0005275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amine transmembrane transporter activity
GO:0005275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	amine/polyamine transmembrane transporter activity
RHEA:19288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol <=> a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol
REACT:R-CFA-426522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nonendonucleolytic RISC binds exactly matching target RNAs (Canis familiaris)
RHEA:32107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine = H(+) + pterostilbene + S-adenosyl-L-homocysteine
RHEA:23892	skos:prefLabel	"beta-nitroacrylate reductase"
RHEA:23892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH
RHEA:23892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-nitroacrylate reductase"
REACT:R-HSA-5696007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF3 ligates CoA-SH to VLCFA (Homo sapiens)
REACT:R-RNO-8851804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET recruits GRB2-1:SOS1 (Rattus norvegicus)
RHEA:69334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+)
GO:0033556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity
GO:0033556	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity
REACT:R-BTA-977615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates MCP/CR1-bound C4b/C3b (Bos taurus)
REACT:R-BTA-2172666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 binds condensin II (Bos taurus)
GO:0018629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinolin-2-ol 5,6-dioxygenase activity
GO:0018629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyquinoline 5,6-dioxygenase activity
GO:0018629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)
GO:0018629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity
GO:0018629	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	quinolin-2(1H)-one 5,6-dioxygenase activity
REACT:R-CFA-202703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD47 binds SIRP (Canis familiaris)
REACT:R-DRE-204364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO1 binds SLIT2 (Danio rerio)
REACT:R-SSC-2470935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Sus scrofa)
REACT:R-SSC-374723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nociceptin receptor binds to nociceptin (Sus scrofa)
REACT:R-GGA-4615905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB1 with SUMO1 (Gallus gallus)
GO:0015657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain amino acid:sodium symporter activity
RHEA:72775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-carboxymellein + ATP + L-phenylalanine = ADP + H(+) + ochratoxin B + phosphate
RHEA:64627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geraniol + acetyl-CoA <=> (2E)-geranyl acetate + CoA
REACT:R-SCE-5687086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1,2,3 phosphorylates MAPK6,4 (Saccharomyces cerevisiae)
REACT:R-HSA-9018895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Homo sapiens)
REACT:R-DDI-1676114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)
RHEA:35972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate => diphosphate + fumitremorgin B
RHEA:16363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-methyl-2-oxobutanoate => 2-acetolactate
RHEA:20842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + histamine => H(+) + L-histidine
RHEA:57128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 oxidized [azurin] + tyramine = (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]
REACT:R-MMU-196126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHOL translocates from cytosol to mitochondrial intermembrane space (Mus musculus)
RHEA:39792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:11590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + isoquinolin-1(2H)-one => A + H2O + isoquinoline
GO:0070005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type aminopeptidase activity
REACT:R-HSA-379974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)
RHEA:57036	skos:prefLabel	"sucrose--1,6-alpha-glucan 3(6)-alpha-glucosyltransferase"
RHEA:57036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sucrose--1,6-alpha-glucan 3(6)-alpha-glucosyltransferase"
RHEA:57036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->6)-alpha-D-glucosyl](n) + sucrose = (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose
RHEA:57036	skos:altLabel	"water-soluble-glucan synthase"
RHEA:43749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexacosanoate => AMP + diphosphate + hexacosanoyl-CoA
RHEA:51802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adlupulone + diphosphate + H(+) => deoxyadlupulone + dimethylallyl diphosphate
RHEA:43217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine => (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-MMU-9021660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K binds membrane-associated estrogen receptors (Mus musculus)
RHEA:72231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) = chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)
REACT:R-SCE-427666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC26A3,6 exchange Cl- for HCO3- (Saccharomyces cerevisiae)
REACT:R-DDI-109857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K1 binds MAPK3 (Dictyostelium discoideum)
REACT:R-CEL-1604350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP14:TIMP2 binds proMMP2 (Caenorhabditis elegans)
REACT:R-DME-416698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA5A binds to PLXNB3 (Drosophila melanogaster)
REACT:R-MMU-5610754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Mus musculus)
REACT:R-SSC-3134962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX36 binds DNA (Sus scrofa)
REACT:R-RNO-159868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor VII to factor VII (Rattus norvegicus)
REACT:R-BTA-159826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Bos taurus)
RHEA:29341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-malate(out) + 2 H(+)(out) => (S)-malate(in) + 2 H(+)(in)
REACT:R-BTA-9653595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pS181-S-Farn-Me KRAS4B binds BCL2L1 (Bos taurus)
REACT:R-GGA-927836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)
REACT:R-DME-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Drosophila melanogaster)
RHEA:70164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + methotrexate(in) => H(+)(out) + methotrexate(out)
RHEA:60107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]
REACT:R-SSC-5661126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Sus scrofa)
REACT:R-HSA-8956684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITCH polyubiquitinates TP73 (Homo sapiens)
REACT:R-RNO-879222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDP:NLRP1 binds ATP (Rattus norvegicus)
RHEA:39189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-docosenoyl-CoA + H2O => (3R)-hydroxydocosanoyl-CoA
REACT:R-DME-112395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Abortive termination of elongation after arrest (Drosophila melanogaster)
REACT:R-CFA-1482781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Canis familiaris)
RHEA:34271	skos:altLabel	"2NI denitrase"
RHEA:34271	skos:altLabel	"2NI nitrohydrolase"
RHEA:34271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitroimidazole + H2O = 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite
RHEA:34271	skos:prefLabel	"2-nitroimidazole nitrohydrolase"
RHEA:34271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-nitroimidazole nitrohydrolase"
RHEA:54272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate
REACT:R-RNO-8952382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 polyubiquitinates RUNX3 (Rattus norvegicus)
REACT:R-DRE-983427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of peptide bound class I MHC on cell surface (Danio rerio)
GO:0004621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycoprotein-phosphatidylinositol phosphatidohydrolase activity
GO:0004621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylinositol-glycan-specific phospholipase D activity
GO:0004621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycosylphosphatidylinositol phospholipase D activity
GO:0004621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylinositol phospholipase D activity
GO:0004621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylinositol-specific phospholipase D activity
GO:0004621	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GPI-PLD activity
GO:0004621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycoprotein phospholipase D activity
REACT:R-BTA-5693691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1 trimer.CES2 hydrolyse COCN to BEG (Bos taurus)
REACT:R-HSA-9757456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,5-DHBA translocates from ER lumen to mitochondrial matrix (Homo sapiens)
RHEA:21180	skos:prefLabel	"indoleacetylglucose--inositol O-acyltransferase"
RHEA:21180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = D-glucose + indole-3-acetyl-1D-myo-inositol
RHEA:21180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"indoleacetylglucose--inositol O-acyltransferase"
RHEA:11685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylarsonous acid + S-adenosyl-L-methionine => dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine
REACT:R-DRE-9692376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL2 binds BCL2 antagonists (Danio rerio)
RHEA:21387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-phenylalanine <=> (E)-cinnamate + NH4(+)
GO:0103087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiopentylmalate dehydrogenase activity
RHEA:29982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxyadenosine(in) + H(+)(in) <=> 2'-deoxyadenosine(out) + H(+)(out)
RHEA:37056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate => 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate
REACT:R-RNO-4551679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates RANBP2 with SUMO2 (Rattus norvegicus)
REACT:R-SCE-1675813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Saccharomyces cerevisiae)
REACT:R-DDI-8952726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Dictyostelium discoideum)
REACT:R-SSC-5661290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Sus scrofa)
REACT:R-BTA-8936481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)
REACT:R-CEL-917933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Caenorhabditis elegans)
REACT:R-RNO-9014074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin4 (Rattus norvegicus)
REACT:R-CFA-5675656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA:EDAR binds EDARADD (Canis familiaris)
REACT:R-DDI-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)
REACT:R-RNO-8954468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Rattus norvegicus)
RHEA:12684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatinine + H(+) + H2O <=> N-methylhydantoin + NH4(+)
REACT:R-HSA-4551297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALG11 does not transfer Man to the N-glycan precursor (Homo sapiens)
RHEA:11014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + NH4(+) => H2O + L-tryptophanamide
REACT:R-HSA-6809810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Homo sapiens)
RHEA:31223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-beta-D-glucosyl-2-hydroxycinnamate + H2O = beta-D-glucose + cis-2-coumarate
GO:0008791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:L-arginine N2-succinyltransferase activity
GO:0008791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AOST activity
GO:0008791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine N-succinyltransferase activity
GO:0008791	skos:altLabel	"arginine and ornithine N(2)-succinyltransferase"
GO:0008791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine and ornithine N2-succinyltransferase activity
GO:0008791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AstA
GO:0008791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginine N-succinyltransferase"
GO:0008791	skos:altLabel	"AOST"
GO:0008791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine and ornithine N(2)-succinyltransferase activity
GO:0008791	skos:altLabel	"arginine succinyltransferase"
GO:0008791	skos:altLabel	"AST"
GO:0008791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	arginine succinyltransferase activity
GO:0008791	skos:prefLabel	"arginine N-succinyltransferase"
GO:0008791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AST activity
GO:0008791	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	succinyl-CoA:L-arginine 2-N-succinyltransferase activity
REACT:R-XTR-170131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Xenopus tropicalis)
REACT:R-HSA-2317531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum (Homo sapiens)
GO:0102511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity
RHEA:21654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + chloride + CO2 + NAD(+) => 2-chlorobenzoate + H(+) + NADH + O2
REACT:R-HSA-5624486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFKs phosphorylates RAF1 on Y340,Y341 (Homo sapiens)
RHEA:32401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2R,4S)-neodihydrocarveol + NAD(+)
EC:1.3.1.101	skos:altLabel	"DGGGPL reductase"
EC:1.3.1.101	skos:altLabel	"2,3-digeranylgeranylglycerophospholipid reductase"
EC:1.3.1.101	skos:altLabel	"digeranylgeranylglycerophospholipid reductase"
EC:1.3.1.101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]"
EC:1.3.1.101	skos:prefLabel	"2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]"
RHEA:22832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formimidoylglutamate deiminase"
RHEA:22832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH4(+)
RHEA:22832	skos:altLabel	"formiminoglutamate deiminase"
RHEA:22832	skos:prefLabel	"formimidoylglutamate deiminase"
RHEA:62987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanamide <=> hexadecanoate + NH4(+)
RHEA:59045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dammarenediol-II + UDP-alpha-D-glucose => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP
REACT:R-MMU-9604767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLT3LG dimer:FLT3 dimer autophosphorylates (Mus musculus)
REACT:R-MMU-3465448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at DISC (Mus musculus)
RHEA:58479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an acyl-CoA + sn-glycerol 3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + CoA
RHEA:25650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,5R)-isopulegone + NADP(+) => (6R)-isopiperitenone + H(+) + NADPH
REACT:R-DRE-211874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2S1 4-hydroxylates atRA (Danio rerio)
REACT:R-GGA-432237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Gallus gallus)
REACT:R-GGA-8964284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTK in active Gq-BTK complex is activated (Gallus gallus)
REACT:R-MMU-420593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR:PVRL3 trans heterodimer interaction (Mus musculus)
RHEA:21988	skos:altLabel	"Ss5MaT1"
RHEA:21988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside = 4'''-demalonylsalvianin + CoA
RHEA:21988	skos:prefLabel	"anthocyanin 5-O-glucoside 6'''-O-malonyltransferase"
RHEA:21988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthocyanin 5-O-glucoside 6'''-O-malonyltransferase"
REACT:R-GGA-379464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COMT transfers Met to DOPAC to form HVA (Gallus gallus)
RHEA:51370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-octadecanoylglycine => glycine + octadecanoyl-CoA
RHEA:57953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + phenol => catechol + H2O + NAD(+)
RHEA:28336	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP + diphosphate + H(+) => dATP + H2O
REACT:R-XTR-9714477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)
RHEA:39715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O
REACT:R-GGA-443783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of NUMB with L1 (Gallus gallus)
RHEA:61533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]
RHEA:53371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrouridine(17) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(17) in tRNA
REACT:R-HSA-163798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein Z to protein Z (Homo sapiens)
RHEA:14581	skos:prefLabel	"monodehydroascorbate reductase (NADH)"
RHEA:14581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 monodehydro-L-ascorbate radical + NADH = 2 L-ascorbate + NAD(+)
RHEA:14581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"monodehydroascorbate reductase (NADH)"
REACT:R-SPO-198756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK1/2 phosphorylates MSK1 (Schizosaccharomyces pombe)
RHEA:10727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-6-deoxy-alpha-D-talose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
REACT:R-HSA-3697882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN (Homo sapiens)
REACT:R-XTR-975926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Xenopus tropicalis)
REACT:R-CFA-9759209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2 binds extracellular TCN2:RCbl (Canis familiaris)
REACT:R-BTA-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Bos taurus)
RHEA:34019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerol + H2O = a fatty acid + glycerol + H(+)
REACT:R-HSA-9033533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
REACT:R-BTA-6814684	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-SNARE binds SNAPs and NSF hexamer at the TGN (Bos taurus)
REACT:R-DDI-2990833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conjugation of SUMO1 to UBA2:SAE1 (Dictyostelium discoideum)
REACT:R-XTR-388596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanocortin receptors bind melanocortins (Xenopus tropicalis)
RHEA:42359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA
RHEA:32889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 all-trans-retinal => all-trans-beta-carotene + O2
REACT:R-SSC-2187405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 binds phosphorylated SMAD2/3 (Sus scrofa)
RHEA:12579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose <=> (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP
REACT:R-XTR-5660660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p300 acetylates RELA subunit (Xenopus tropicalis)
RHEA:21705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-tyrosine => NH4(+) + phenol + pyruvate
REACT:R-HSA-9766677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds KEAP1 and SQSTM1 (Homo sapiens)
RHEA:71837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrone 3-sulfate(in) => estrone 3-sulfate(out)
RHEA:68426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => (3R)-3-hydroxy-10'-apo-beta-carotenal + O2
REACT:R-XTR-927789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)
RHEA:23724	skos:prefLabel	"pyridoxal oxidase"
RHEA:23724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyridoxal oxidase"
RHEA:23724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + pyridoxal = 4-pyridoxate + H(+) + H2O2
REACT:R-MMU-1454781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Mus musculus)
REACT:R-MMU-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Mus musculus)
REACT:R-SPO-6800793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 translocates to the cytosol (Schizosaccharomyces pombe)
REACT:R-BTA-177920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2 to GAB1 (Bos taurus)
RHEA:33173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose(out) => D-maltose(in)
RHEA:69683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	daidzein 7-O-beta-D-glucoside + H2O = beta-D-glucose + daidzein + H(+)
RHEA:33010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
GO:0018544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxy-4'-sulfoazobenzene reductase activity
GO:0018544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxy-4'-sulphoazobenzene reductase activity
REACT:R-GGA-170844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Latent TGF-beta-1 is cleaved by FURIN (Gallus gallus)
GO:0015334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high affinity oligopeptide transporter activity
GO:0015334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	high-affinity oligopeptide transmembrane transporter activity
GO:0015334	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	high-affinity oligopeptide transporter activity
RHEA:44590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O
REACT:R-XTR-9728664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLP1R binds GLP1R agonists (Xenopus tropicalis)
GO:0032129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 deacetylase activity
GO:0032129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K9 deacetylase activity
GO:0032129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone deacetylase activity (H3-K9 specific)
RHEA:64329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z)-octadecenoyl-CoA + cholesterol => cholesteryl (7Z)-octadecenoate + CoA
REACT:R-DRE-193535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Danio rerio)
REACT:R-DRE-9038163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Danio rerio)
EC:1.8.3.6	skos:altLabel	"FC lyase"
EC:1.8.3.6	skos:prefLabel	"farnesylcysteine lyase"
EC:1.8.3.6	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"farnesylcysteine lyase"
REACT:R-MMU-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Mus musculus)
REACT:R-SSC-8950183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B binds IL23A (Sus scrofa)
RHEA:60034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-GDP + H(+) + phosphate => 8-oxo-GTP + H2O
REACT:R-XTR-4724284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Xenopus tropicalis)
REACT:R-GGA-1067659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of hexameric IL-6 receptor (Gallus gallus)
RHEA:18908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + phosphonoacetaldehyde <=> acetaldehyde + H(+) + phosphate
REACT:R-SSC-5628871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRD7 promotes EP300-mediated acetylation of TP53 (Sus scrofa)
RHEA:69593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + inosine => cytidine + IMP
RHEA:66578	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-isopropylphenol
REACT:R-SSC-158481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Sus scrofa)
REACT:R-RNO-1855157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)
RHEA:37787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-DME-428015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Drosophila melanogaster)
RHEA:69423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O2 + iodide <=> H2O + hypoiodite
REACT:R-CEL-114688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC-beta hydrolyses PIP2 to DAG and IP3 (Caenorhabditis elegans)
REACT:R-RNO-983427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of peptide bound class I MHC on cell surface (Rattus norvegicus)
REACT:R-SSC-3000074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TCN2 binds RCbl in the circulation (Sus scrofa)
RHEA:67732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA
REACT:R-HSA-9614367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HCMV Nuclear Pore Docking (Homo sapiens)
RHEA:24861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose = H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP
GO:0051575	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dRP lyase activity
GO:0051575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyribose-5-phosphate lyase activity
GO:0051575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyribose phosphate activity
GO:0051575	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	dRPase activity
GO:0019237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	centromere binding
GO:0019237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	centromeric DNA binding
GO:0042389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	omega-3 fatty acid desaturase activity
REACT:R-HSA-6789310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyse TG to DAG and RCOOH (Homo sapiens)
REACT:R-SSC-5675656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDA:EDAR binds EDARADD (Sus scrofa)
RHEA:57332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 3 O2 + 3 propionate 3-nitronate = 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite
RHEA:29897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-glutamine(in) + phosphate => ATP + H2O + L-glutamine(out)
REACT:R-DRE-2022851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXT1:EXT2 transfer GlcNAc to the heparan chain (Danio rerio)
REACT:R-MMU-6788810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AK6 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)
RHEA:52990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine => [deoxyhypusine synthase]-L-lysine + dehydrospermidine
RHEA:57950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylcatechol + H2O + NAD(+) => 2-hydroxytoluene + H(+) + NADH + O2
REACT:R-CFA-9692800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 translocates to the endoplasmic reticulum membrane (Canis familiaris)
REACT:R-DRE-6803875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFN dimer binds CDK1 and CCNB1 (Danio rerio)
REACT:R-CEL-6783177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP21 deubiquitinates GATA3,IL33 (Caenorhabditis elegans)
RHEA:42220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
RHEA:14501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homocysteine desulfhydrase"
RHEA:14501	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-homocysteine = 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)
RHEA:14501	skos:altLabel	"homocysteine desulfurase"
RHEA:14501	skos:prefLabel	"homocysteine desulfhydrase"
REACT:R-CEL-1855216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)
REACT:R-BTA-170977	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FRS2 is phosphorylated by active TrkA receptor (Bos taurus)
GO:0008147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of bone
REACT:R-MMU-174227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Mus musculus)
REACT:R-CFA-877198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates membrane pores that include pannexin-1 (Canis familiaris)
GO:0036313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K catalytic subunit binding
GO:0036313	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p110 binding
GO:0036313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol 3-kinase catalytic subunit binding
REACT:R-CFA-2395879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
RHEA:47032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA-uridine 2-sulfurtransferase"
RHEA:47032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]
RHEA:47032	skos:prefLabel	"tRNA-uridine 2-sulfurtransferase"
REACT:R-SSC-8848023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated PTK6 binds STAP2 (Sus scrofa)
REACT:R-SSC-5357831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYLD is phosphorylated by IKK (Sus scrofa)
REACT:R-RNO-1855158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)
REACT:R-DRE-202722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD48 binds CD244 (Danio rerio)
REACT:R-DME-4570499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Drosophila melanogaster)
RHEA:71542	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + 2 nitrate(out) <=> H(+)(in) + 2 nitrate(in)
RHEA:22584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + heme b = Fe(2+) + protoporphyrin IX
REACT:R-HSA-3560794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS (Homo sapiens)
RHEA:58586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-tabersonine + acetate + H(+) => dihydroprecondylocarpine acetate
RHEA:57055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate + H(+) <=> CO2 + L-erythrulose
EC:3.4.22.71	skos:altLabel	"SrtB"
EC:3.4.22.71	skos:prefLabel	"sortase B"
EC:3.4.22.71	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sortase B"
REACT:R-SSC-9700171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ALK phosphorylates PLCG1 (Sus scrofa)
GO:0036443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dermatan 6-sulfotransferase activity
RHEA:29482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epicubenol + diphosphate
RHEA:41679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + ATP <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-CFA-2730894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)
REACT:R-SSC-449911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Sus scrofa)
REACT:R-BTA-443997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Bos taurus)
REACT:R-RNO-9626914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	α2-agonists bind ADRA2A,B,C (Rattus norvegicus)
RHEA:18947	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2
REACT:R-XTR-751001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactive G alpha (i) reassociates with G beta:gamma (Xenopus tropicalis)
REACT:R-XTR-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)
GO:0005134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-2 receptor ligand
GO:0005134	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-2
GO:0005134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-2 receptor binding
RHEA:52989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[deoxyhypusine synthase]-L-lysine + dehydrospermidine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine
RHEA:17351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate => (2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole
REACT:R-SSC-109903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Sus scrofa)
REACT:R-DDI-70262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Dictyostelium discoideum)
REACT:R-DDI-5668731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOX3 complex:RAC1:GTP generates superoxide from oxygen (Dictyostelium discoideum)
RHEA:14915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine + dTMP => AMP + thymidine
REACT:R-MMU-193997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP11B1 oxidises 11DCORT (Mus musculus)
REACT:R-SSC-174058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Cdh1 (Sus scrofa)
REACT:R-GGA-212710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR activates PLC-gamma1 by phosphorylation (Gallus gallus)
REACT:R-HSA-110164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMUG1 glycosylase mediated recognition and binding of uracil in DNA (Homo sapiens)
REACT:R-GGA-354124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of pPTK2 by SRC (Gallus gallus)
RHEA:68757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine
RHEA:38367	skos:prefLabel	"tetracycline polyketide synthase"
RHEA:38367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tetracycline polyketide synthase"
RHEA:38367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA = 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA
GO:0001873	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	polysaccharide receptor activity
GO:0001873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polysaccharide immune receptor activity
REACT:R-XTR-177942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR binds EGF ligand (Xenopus tropicalis)
REACT:R-HSA-9617852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOXO3,FOXO4,(FOXO1) bind GADD45A gene promoter (Homo sapiens)
REACT:R-BTA-420818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Bos taurus)
RHEA:33022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3,6-diaminohexanoate + acetyl-CoA <=> (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)
RHEA:52215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:65817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate
REACT:R-HSA-390641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA1A,B,D bind ADR,NAd (Homo sapiens)
RHEA:56492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hederagenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
EC:3.4.24.64	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mitochondrial processing peptidase"
EC:3.4.24.64	skos:altLabel	"processing enhancing peptidase"
EC:3.4.24.64	skos:prefLabel	"mitochondrial processing peptidase"
GO:0043861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine/putrescine antiporter activity
GO:0043861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine:putrescine antiporter activity
GO:0043861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatine-putrescine antiporter activity
REACT:R-BTA-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Bos taurus)
REACT:R-GGA-9626832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Gallus gallus)
RHEA:42593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
GO:0045545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	syndecan binding
REACT:R-SSC-70903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urocanate + H2O => 4-imidazolone-5-propionate (Sus scrofa)
REACT:R-MMU-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)
RHEA:38322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chorismate + H2O <=> (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate
RHEA:35030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + tungstate(in) <=> ADP + H(+) + phosphate + tungstate(out)
REACT:R-DRE-6800035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IGFBP3 binds TMEM219 (Danio rerio)
RHEA:17979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain fatty acid + 3 H(+) + 2 NADH => a long-chain primary fatty alcohol + H2O + 2 NAD(+)
RHEA:54910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH
REACT:R-XTR-192054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Xenopus tropicalis)
RHEA:47845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate
REACT:R-BTA-9659680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCB1 transports xenobiotics out of the cell (Bos taurus)
RHEA:19923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + H(+) + NADPH => D-ribitol 5-phosphate + NADP(+)
REACT:R-HSA-174105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
REACT:R-CFA-176298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of claspin (Canis familiaris)
REACT:R-HSA-77593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
REACT:R-DRE-70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fumarate + H2O <=> (S)-Malate (Danio rerio)
RHEA:60186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + D-glucose(in) + H(+) + phosphate => ATP + D-glucose(out) + H2O
REACT:R-RNO-5696457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BDH2 dehydrogenates 3HBA (Rattus norvegicus)
RHEA:66308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an inositol-1-phosphoceramide + GDP-alpha-D-mannose = an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)
GO:0103046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alanylglutamate dipeptidase activity
REACT:R-SSC-5665748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds RHOC:GTP (Sus scrofa)
RHEA:65387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)
RHEA:37957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
GO:0052736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucanase activity
GO:0052736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-glucanase activity
RHEA:66286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP => tomatidine + UDP-alpha-D-glucose
REACT:R-DRE-981728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to membrane-associated C3b (Danio rerio)
RHEA:45308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin D2-ethanolamide = 11beta-prostaglandin F2-ethanolamide + NADP(+)
REACT:R-GGA-9700120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTN and MDK bind to PTPRZ (Gallus gallus)
REACT:R-MMU-176521	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Mus musculus)
RHEA:23058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanamide + H2O => urea
RHEA:59993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + phloretate => (E)-4-coumarate + reduced [electron-transfer flavoprotein]
REACT:R-BTA-8937442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)
REACT:R-XTR-1449687	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticosteroids bind to CBG in blood (Xenopus tropicalis)
REACT:R-SSC-9626928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CREBBP binds FOXO1 (Sus scrofa)
REACT:R-CFA-3132753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pancreatic proteases degrade TCN1:RCbl (Canis familiaris)
RHEA:28095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl diphosphate + H2O => di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate
RHEA:59919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H2O + NADP(+) <=> (2E)-octenoate + 2 H(+) + NADPH
REACT:R-MMU-8982637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins binds G alpha-t (Mus musculus)
REACT:R-HSA-2186767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SKI/SKIL (Homo sapiens)
RHEA:38009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine
RHEA:36553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+) => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol
REACT:R-HSA-5623513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)
REACT:R-HSA-5696534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)
GO:0051994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-methyltransferase activity
REACT:R-XTR-375330	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Connexin 45/Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)
REACT:R-HSA-8851804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET recruits GRB2-1:SOS1 (Homo sapiens)
REACT:R-RNO-73618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Rattus norvegicus)
RHEA:70025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-L-proline(out) + Na(+)(out) => 4-hydroxy-L-proline(in) + Na(+)(in)
REACT:R-BTA-1254291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds STAT5A (Bos taurus)
RHEA:27270	skos:altLabel	"hexadecanal dehydrogenase (acylating, NADP dependent)"
RHEA:27270	skos:prefLabel	"fatty acyl-CoA reductase"
RHEA:27270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + hexadecanal + NADP(+) = H(+) + hexadecanoyl-CoA + NADPH
RHEA:27270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"fatty acyl-CoA reductase"
RHEA:27270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)
REACT:R-RNO-400586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) binds to Trio family RhoGEFs (Rattus norvegicus)
REACT:R-CFA-1678694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Canis familiaris)
REACT:R-DME-350396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSH binds to DAAM (Drosophila melanogaster)
RHEA:10120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+)
RHEA:10120	skos:prefLabel	"double-stranded RNA adenine deaminase"
RHEA:10120	skos:altLabel	"double-stranded RNA-specific adenosine deaminase"
RHEA:10120	skos:altLabel	"dsRNA adenosine deaminase"
RHEA:10120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"double-stranded RNA adenine deaminase"
RHEA:10120	skos:altLabel	"double-stranded RNA adenosine deaminase"
REACT:R-DME-6814086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFRP1 recruits ARL1 to the TGN (Drosophila melanogaster)
RHEA:47561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) => CMP + ganglioside GM1b (d18:1(4E)) + H(+)
REACT:R-DRE-2022860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Danio rerio)
RHEA:12976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> 2 ADP
REACT:R-SSC-5654618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
GO:0047564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxycyclohexanone dehydrogenase activity
GO:0047564	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity
RHEA:53254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lathosterol + O2 + reduced [NADPH--hemoprotein reductase]
EC:2.1.1.337	skos:prefLabel	"reticuline N-methyltransferase"
EC:2.1.1.337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"reticuline N-methyltransferase"
REACT:R-MMU-165680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of active mTORC1 complex (Mus musculus)
RHEA:56872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-N-acetyl-1-phenylethylamine hydrolase"
RHEA:56872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-N-acetyl-1-phenylethylamine + H2O = (S)-1-phenylethylamine + acetate
RHEA:56872	skos:altLabel	"(S)-N-acetyl-1-phenylethylamine amidohydrolase"
RHEA:56872	skos:prefLabel	"(S)-N-acetyl-1-phenylethylamine hydrolase"
RHEA:13629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH
RHEA:13629	skos:prefLabel	"carveol dehydrogenase"
RHEA:13629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carveol dehydrogenase"
RHEA:13658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[citrate lyase ACP] + H2O => acetate + H(+) + holo-[citrate lyase ACP]
REACT:R-SSC-8853762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RET dimerizes (Sus scrofa)
EC:1.1.1.284	skos:altLabel	"NAD- and glutathione-dependent formaldehyde dehydrogenase"
EC:1.1.1.284	skos:altLabel	"NAD-dependent formaldehyde dehydrogenase"
EC:1.1.1.284	skos:altLabel	"class III alcohol dehydrogenase"
EC:1.1.1.284	skos:altLabel	"GS-FDH"
EC:1.1.1.284	skos:prefLabel	"S-(hydroxymethyl)glutathione dehydrogenase"
EC:1.1.1.284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"S-(hydroxymethyl)glutathione dehydrogenase"
EC:1.1.1.284	skos:altLabel	"FDH"
EC:1.1.1.284	skos:altLabel	"ADH3"
EC:1.1.1.284	skos:altLabel	"formaldehyde dehydrogenase"
EC:1.1.1.284	skos:altLabel	"formaldehyde dehydrogenase (glutathione)"
EC:1.1.1.284	skos:altLabel	"GD-FALDH"
EC:1.1.1.284	skos:altLabel	"chi-ADH"
EC:1.1.1.284	skos:altLabel	"NAD-linked formaldehyde dehydrogenase"
EC:1.1.1.284	skos:altLabel	"formic dehydrogenase"
EC:1.1.1.284	skos:altLabel	"glutathione-dependent formaldehyde dehydrogenase"
REACT:R-HSA-9640302	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Asc.- radical dissociates to AscH- and DeHA (Homo sapiens)
REACT:R-DME-5334827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2 binds atRA (Drosophila melanogaster)
RHEA:12070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] => apo-[ACP] + CoA
RHEA:20929	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[DsbA protein]-dithiol + a quinone => [DsbA protein]-disulfide + a quinol
RHEA:27301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formylbenzoate + H2O + NAD(+) <=> 2 H(+) + NADH + phthalate
REACT:R-GGA-2132206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MASPs activation (Gallus gallus)
RHEA:24391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + uridine <=> alpha-D-ribose 1-phosphate + uracil
REACT:R-BTA-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
REACT:R-RNO-9661408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Rattus norvegicus)
REACT:R-HSA-392064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (z) inhibits adenylate cyclase (Homo sapiens)
REACT:R-DME-8939801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)
REACT:R-RNO-428260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Rattus norvegicus)
REACT:R-XTR-162721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Xenopus tropicalis)
RHEA:10341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate => (-)-vetispiradiene + diphosphate
RHEA:48109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine
RHEA:59244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)
REACT:R-CFA-381026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Canis familiaris)
RHEA:55459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol
RHEA:68471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6Z)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate
REACT:R-SSC-8932633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Sus scrofa)
RHEA:30505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + L-glutamate 5-semialdehyde => H2O + N-acetyl-L-glutamate 5-semialdehyde
REACT:R-RNO-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Rattus norvegicus)
REACT:R-RNO-5694126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NT5C3B hydrolyses 7MGP to 7MG (Rattus norvegicus)
RHEA:43553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate
REACT:R-BTA-109380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)
REACT:R-HSA-5211387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Anthrax lef cleaves target cell MAP2K7 (MEK7) (Homo sapiens)
REACT:R-HSA-994148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRRC16A binds F-actin capping protein (Homo sapiens)
RHEA:29093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + 4 H(+)(out) + NAD(+) => a ubiquinone + 5 H(+)(in) + NADH
RHEA:72610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-sinapoyl-AMP + CoA <=> (E)-sinapoyl-CoA + AMP + H(+)
RHEA:55562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a hydroxy-epoxy-eicosatetraenoate => a hydroperoxyeicosatetraenoate
GO:0004904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN receptor activity
GO:0004904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interferon receptor activity
RHEA:32916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sn-glycero-3-phospho-1D-myo-inositol(out) => sn-glycero-3-phospho-1D-myo-inositol(in)
REACT:R-DME-264865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Lamin A (Drosophila melanogaster)
REACT:R-RNO-8987097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Rattus norvegicus)
REACT:R-DME-70609	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamine + H2O => glutamate + NH4+ [GLS] (Drosophila melanogaster)
REACT:R-HSA-1855203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 transports from the nucleus to the cytosol (Homo sapiens)
RHEA:16085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
REACT:R-DRE-5693615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Danio rerio)
REACT:R-DRE-9008694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL37, IL37(?-218) translocates from cytosol to extracellular region (Danio rerio)
GO:0047967	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycyrrhizinate glucuronosylhydrolase activity
GO:0047967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhizinate beta-glucuronidase activity
GO:0047967	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycyrrhizin hydrolase activity
GO:0047967	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycyrrhizinic acid hydrolase activity
GO:0047967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycyrrhizinate b-glucuronidase activity
GO:0047967	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycyrrhizin beta-hydrolase activity
REACT:R-GGA-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Gallus gallus)
RHEA:56810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase]
RHEA:53770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allocholoyl-CoA + allodeoxycholate => allocholate + allodeoxycholoyl-CoA
RHEA:24268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase"
RHEA:24268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH
RHEA:24268	skos:prefLabel	"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase"
RHEA:60741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(-)-citronellal + H2O + NADP(+) => (S)-(-)-citronellate + 2 H(+) + NADPH
REACT:R-HSA-9036307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPER:Heterotrimeric G-protein Gs binds ESTG (Homo sapiens)
RHEA:20390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)
RHEA:19664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol 1-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH
REACT:R-BTA-113414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Bos taurus)
GO:0102451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferide 3-O-methyltransferase activity
REACT:R-RNO-5229343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AXIN is phosphorylated in the destruction complex (Rattus norvegicus)
RHEA:65057	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycochenodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH
RHEA:68189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + phytol => CoA + dodecanoate phytyl ester
REACT:R-RNO-8951661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of NEDD8 to AcM-UBE2M (Rattus norvegicus)
REACT:R-DRE-5624494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1 binds p21 RAS:GTP (Danio rerio)
REACT:R-HSA-9018817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 GEFs activate RHOT1 (Homo sapiens)
RHEA:58842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:20982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 biliverdin IXalpha + 2 H2O => 2 bilirubin IXalpha + O2
REACT:R-RNO-8953917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Rattus norvegicus)
RHEA:72304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamate(in) + L-thyroxine(out) => L-glutamate(out) + L-thyroxine(in)
RHEA:16032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-guanidinopropanoate + H2O <=> beta-alanine + urea
RHEA:55146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH => [(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+)
REACT:R-BTA-9755304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUL1 ubiquitinates UBXN7 (Bos taurus)
REACT:R-DRE-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Danio rerio)
RHEA:35728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + sn-glycerol 3-phosphate => 1-dodecanoyl-sn-glycerol 3-phosphate + CoA
RHEA:22189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (R)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)
REACT:R-MMU-9632182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT1 methylates ESRs (Mus musculus)
RHEA:31751	skos:prefLabel	"7-hydroxymethyl chlorophyll a reductase"
RHEA:31751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:31751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"7-hydroxymethyl chlorophyll a reductase"
RHEA:31751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-XTR-9026780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)
REACT:R-SSC-8951586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-VAV family:PIP3 binds RAC1:GDP (Sus scrofa)
RHEA:36046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-8'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial
RHEA:29107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + ubiquinone-8 = NAD(+) + ubiquinol-8
REACT:R-CEL-744230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Caenorhabditis elegans)
REACT:R-GGA-5339538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAGT1 transports Mg2+ from extracellular region to cytosol (Gallus gallus)
REACT:R-SSC-8938076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD38 hydrolyses NAD+ to NAM and ADP-ribose (Sus scrofa)
RHEA:46222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxyandrost-5-en-17-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)
REACT:R-DME-8854209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D10A binds JFC1 (Drosophila melanogaster)
REACT:R-RNO-549112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G3P is acylated to 1-acyl LPA by AGPAT6 (Rattus norvegicus)
RHEA:59006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + H(+) + H2O2 => dodecanal + H2O + O2
RHEA:22617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 sulochrin => 2 (2R)-bisdechlorogeodin + 2 H2O
REACT:R-CEL-204647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Caenorhabditis elegans)
RHEA:38910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-reticuline + S-adenosyl-L-methionine <=> (R)-laudanine + H(+) + S-adenosyl-L-homocysteine
GO:0034780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyphosate dehydrogenase activity
REACT:R-DDI-5682103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Dictyostelium discoideum)
REACT:R-SSC-9640175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Sus scrofa)
RHEA:62418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzaldehyde + acetyl-CoA => (E)-4-coumaroyl-CoA + H2O
REACT:R-MMU-5654637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)
REACT:R-DRE-2855020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Danio rerio)
REACT:R-DME-451846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LFT binds to FT and DS (Drosophila melanogaster)
RHEA:57163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate
REACT:R-DRE-1592362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of proMMP7 by MMP3 (Danio rerio)
RHEA:58244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] = ADP-D-ribose + L-lysyl-[protein]
REACT:R-GGA-4420117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGFR2 autophosphorylates (Gallus gallus)
GO:0034802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	branched-chain dodecylbenzene sulfonate monooxygenase activity
RHEA:24274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2
REACT:R-HSA-2243937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 (Homo sapiens)
REACT:R-XTR-8851225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase4 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)
RHEA:59173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] => AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]
REACT:R-MMU-204798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and p85 of PI3K (Mus musculus)
RHEA:28673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein]
REACT:R-MMU-1564112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type VI degradation by MMP2,9,11 (Mus musculus)
RHEA:70460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 => a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate
EC:1.14.13.8	skos:altLabel	"dimethylaniline monooxygenase (N-oxide-forming)"
EC:1.14.13.8	skos:altLabel	"N,N-dimethylaniline monooxygenase"
EC:1.14.13.8	skos:altLabel	"dimethylaniline oxidase"
EC:1.14.13.8	skos:altLabel	"FMO"
EC:1.14.13.8	skos:altLabel	"flavin monooxygenase"
EC:1.14.13.8	skos:prefLabel	"flavin-containing monooxygenase"
EC:1.14.13.8	skos:altLabel	"mixed-function amine oxidase"
EC:1.14.13.8	skos:altLabel	"Ziegler's enzyme"
EC:1.14.13.8	skos:altLabel	"DMA oxidase"
EC:1.14.13.8	skos:altLabel	"methylphenyltetrahydropyridine N-monooxygenase"
EC:1.14.13.8	skos:altLabel	"FAD-containing monooxygenase"
EC:1.14.13.8	skos:altLabel	"dimethylaniline N-oxidase"
EC:1.14.13.8	skos:altLabel	"flavin mixed function oxidase"
EC:1.14.13.8	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavin-containing monooxygenase"
REACT:R-HSA-9664850	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM binds PEX5 (Homo sapiens)
REACT:R-HSA-446648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)
RHEA:47932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-3-sulfolactaldehyde + H2O + NAD(+) = (2S)-3-sulfolactate + 2 H(+) + NADH
RHEA:57479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoate + H2O2 <=> 2-hydroxydodecanoate + H2O
RHEA:62232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a thymidine(6-4)thymidine in DNA = a thymidine dimer in DNA
REACT:R-RNO-6814559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pre-snRNA is elongated and capped with 7-methylguanosine (Rattus norvegicus)
GO:0046915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transition metal ion transmembrane transporter activity
GO:0005055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	laminin receptor activity
RHEA:63204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + octadecanoyl-[ACP] = H(+) + holo-[ACP] + octadecanoate
GO:0047658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-amino acid ester hydrolase activity
GO:0047658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-amino-acid-ester aminoacylhydrolase activity
GO:0047658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-amino-acid esterase activity
GO:0047658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-amino-acid esterase activity
GO:0047658	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alpha-amino-acid ester hydrolase activity
REACT:R-MMU-209532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR C-terminal fragment enters endosomes (Mus musculus)
RHEA:39543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)
RHEA:21410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + H(+) + NADH + NH4(+) => H2O + L-phenylalanine + NAD(+)
REACT:R-MMU-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Mus musculus)
RHEA:21782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AH2 + cyclohex-2-enone => A + cyclohexanone
REACT:R-RNO-202706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha4beta1 binds JAM2:JAM3 (Rattus norvegicus)
RHEA:14926	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannitol 1-phosphate + NADP(+) => D-mannose 6-phosphate + H(+) + NADPH
RHEA:28948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-arabinose(in) => H(+)(in) + L-arabinose(out)
REACT:R-BTA-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Bos taurus)
REACT:R-RNO-8853496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF:FBXL7 binds AURKA (Rattus norvegicus)
RHEA:60452	skos:prefLabel	"isethionate sulfite-lyase"
RHEA:60452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isethionate sulfite-lyase"
RHEA:60452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate = acetaldehyde + H(+) + sulfite
GO:0004408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	holocytochrome-c apocytochrome-c-lyase activity
GO:0004408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	holocytochrome-c apocytochrome-c-lyase (heme-forming)
GO:0004408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holocytochrome-c synthase activity
GO:0004408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c synthase activity
GO:0004408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	holocytochrome c synthetase activity
GO:0004408	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cytochrome c heme-lyase activity
RHEA:25569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + beta-D-ribosylnicotinate => ADP + H(+) + nicotinate beta-D-ribonucleotide
RHEA:51025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADH + O2 + toluene-4-sulfonate => 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)
RHEA:57668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-8950387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX binds EBI3 (Canis familiaris)
RHEA:24016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-epivellosimine + acetyl-CoA = CoA + vinorine
RHEA:24016	skos:prefLabel	"vinorine synthase"
RHEA:24016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vinorine synthase"
REACT:R-RNO-9757951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
RHEA:34921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thiamine(out) => thiamine(in)
REACT:R-BTA-9690439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYSLTR1 binds LTC4,LTD4,LTE4 (Bos taurus)
RHEA:31621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose
RHEA:69653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylpropan-2-ol + glutathione disulfide + H2O => cumene hydroperoxide + 2 glutathione
EC:1.14.15.19	skos:altLabel	"CYP260A1"
EC:1.14.15.19	skos:prefLabel	"C-19 steroid 1alpha-hydroxylase"
EC:1.14.15.19	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"C-19 steroid 1alpha-hydroxylase"
RHEA:63327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycerol + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)
RHEA:45089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline
REACT:R-CEL-392752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of L1 by CK-II (Caenorhabditis elegans)
RHEA:60092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADH
REACT:R-HSA-5679000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ivacaftor binds CFTR G551D (Homo sapiens)
REACT:R-DRE-9018594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MECP2 binds LBR (Danio rerio)
RHEA:34000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	zymosterol => 5alpha-cholesta-7,24-dien-3beta-ol
RHEA:20736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA
RHEA:20736	skos:prefLabel	"glycine C-acetyltransferase"
RHEA:20736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glycine C-acetyltransferase"
RHEA:20736	skos:altLabel	"2-amino-3-ketobutyrate coenzyme A ligase"
RHEA:72867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3',3'-cAAG + H2O = A[3'-5']pG[3'-5']pAp[3'] + H(+)
REACT:R-SSC-8871370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Sus scrofa)
RHEA:66272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate
REACT:R-MMU-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Mus musculus)
REACT:R-HSA-9728697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
REACT:R-SSC-4754187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Sus scrofa)
RHEA:45273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-phosphooxy-(9Z)-octadecenoate + H2O => 12-hydroxy-(9Z)-octadecenoate + phosphate
RHEA:13351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methyl (-)-jasmonate + S-adenosyl-L-homocysteine => jasmonate + S-adenosyl-L-methionine
RHEA:71795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3-hydroxybutanoate(in) + H(+)(in)
REACT:R-SSC-192042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Sus scrofa)
GO:0015549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCCP transporter activity
GO:0015549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carbonyl cyanide m-chlorophenylhydrazone transmembrane transporter activity
GO:0015549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbonyl cyanide m-chlorophenylhydrazone transporter activity
GO:0015549	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity
EC:2.7.1.156	skos:altLabel	"adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase"
EC:2.7.1.156	skos:prefLabel	"adenosylcobinamide kinase"
EC:2.7.1.156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"adenosylcobinamide kinase"
EC:2.7.1.156	skos:altLabel	"AdoCbi kinase/AdoCbi-phosphate guanylyltransferase"
REACT:R-GGA-1250264	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXNIP binds reduced thioredoxin (Gallus gallus)
RHEA:37999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine = H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine
REACT:R-XTR-9714363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)
REACT:R-MMU-83586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Mus musculus)
RHEA:23896	skos:altLabel	"5-keto-4-deoxyuronate isomerase"
RHEA:23896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate
RHEA:23896	skos:prefLabel	"5-dehydro-4-deoxy-D-glucuronate isomerase"
RHEA:23896	skos:altLabel	"4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase"
RHEA:23896	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-dehydro-4-deoxy-D-glucuronate isomerase"
REACT:R-HSA-1237069	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHAG transports CO2 from extracellular region to cytosol (Homo sapiens)
GO:0043717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyglutaryl-CoA dehydratase activity
GO:0043717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-hydroxyglutaryl-CoA dehydratase activity
REACT:R-SSC-388833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CTLA-4 (Sus scrofa)
GO:0047756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin 4-sulphotransferase activity
GO:0047756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chondroitin 4-sulfotransferase activity
GO:0047756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity
GO:0034786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	9-fluorenone-3,4-dioxygenase activity
RHEA:13846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydroxyfumarate + H(+) => 2-hydroxy-3-oxopropanoate + CO2
REACT:R-DME-6790454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC (Drosophila melanogaster)
RHEA:31290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA <=> acryloyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-BTA-9021068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs bind CAVs (Bos taurus)
REACT:R-SSC-2395872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)
EC:3.2.1.10	skos:altLabel	"alpha-methylglucosidase"
EC:3.2.1.10	skos:altLabel	"isomaltase"
EC:3.2.1.10	skos:altLabel	"oligosaccharide alpha-1,6-glucosidase"
EC:3.2.1.10	skos:prefLabel	"oligo-1,6-glucosidase"
EC:3.2.1.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"oligo-1,6-glucosidase"
EC:3.2.1.10	skos:altLabel	"sucrase-isomaltase"
REACT:R-MMU-8856630	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CIDEA:CIDEC binds lipid droplets (Mus musculus)
RHEA:37910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + O2 <=> (8E,10S)-10-hydroperoxy-octadeca-8-enoate
REACT:R-DRE-70745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Danio rerio)
REACT:R-CFA-163215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Canis familiaris)
REACT:R-BTA-469659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A1 dehydrogenates TEST to DHTEST (Bos taurus)
REACT:R-SPO-5679206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR14, MTMR3 dephosphorylate PI3P (Schizosaccharomyces pombe)
RHEA:50822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + testosterone => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)
REACT:R-HSA-9750660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycine conjugates translocates from mitochondrial matrix to cytosol (Homo sapiens)
REACT:R-RNO-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Rattus norvegicus)
REACT:R-BTA-2534346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPAM1 Binds Hyaluronic Acid (Bos taurus)
REACT:R-HSA-427605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)
REACT:R-DME-165692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of 4E-BP1 by activated mTORC1 (Drosophila melanogaster)
RHEA:47374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinol + D-glucono-1,5-lactone => a quinone + D-glucose
REACT:R-CFA-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)
REACT:R-DME-3318415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATF2 acetylates histone H2B, H4 (Drosophila melanogaster)
REACT:R-DDI-71173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	maleylacetoacetate => fumarylacetoacetate (Dictyostelium discoideum)
REACT:R-RNO-351877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 2 (Rattus norvegicus)
RHEA:68890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 2-methoxybenzoate + ATP + H(+) + NADPH
REACT:R-SSC-8952128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX3 binds TP53 (Sus scrofa)
REACT:R-DRE-8850961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PREX2 binds PTEN and inhibits it (Danio rerio)
RHEA:56148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-HSA-8938815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF152 polyubiquitinates RRAGA (Homo sapiens)
REACT:R-MMU-6809663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of hair keratin fibres (Mus musculus)
REACT:R-RNO-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Rattus norvegicus)
REACT:R-SSC-5205861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Sus scrofa)
RHEA:13117	skos:altLabel	"beta-pyrazolealanine synthase"
RHEA:13117	skos:altLabel	"BPA-synthase"
RHEA:13117	skos:altLabel	"pyrazolylalaninase"
RHEA:13117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)
RHEA:13117	skos:altLabel	"O(3)-acetyl-L-serine acetate-lyase (adding pyrazole)"
RHEA:13117	skos:altLabel	"beta-(1-pyrazolyl)alanine synthase"
RHEA:13117	skos:altLabel	"beta-pyrazolylalanine synthase (acetylserine)"
RHEA:13117	skos:altLabel	"pyrazolealanine synthase"
RHEA:13117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"beta-pyrazolylalanine synthase"
RHEA:13117	skos:prefLabel	"beta-pyrazolylalanine synthase"
RHEA:41198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)
REACT:R-SSC-68913	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Sus scrofa)
REACT:R-DME-9753283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)
RHEA:14674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a polar amino acid(out) + ATP + H2O => a polar amino acid(in) + ADP + H(+) + phosphate
REACT:R-BTA-9646679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PolyUb-Misfolded proteins bind vimentin to form aggresome (Bos taurus)
RHEA:24561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-serine => CoA + O-acetyl-L-serine
REACT:R-DRE-159050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Danio rerio)
REACT:R-CEL-8939959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Caenorhabditis elegans)
GO:0015168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol transmembrane transporter activity
REACT:R-DME-9029667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DFF dissociates from importin-alpha:importin-beta (Drosophila melanogaster)
RHEA:48901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
REACT:R-RNO-947531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)
RHEA:14165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aspartate N-acetyltransferase"
RHEA:14165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + L-aspartate = CoA + H(+) + N-acetyl-L-aspartate
RHEA:14165	skos:prefLabel	"aspartate N-acetyltransferase"
REACT:R-CEL-6800426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of ficolin-rich granule membrane proteins (Caenorhabditis elegans)
EC:1.14.12.1	skos:altLabel	"anthranilic hydroxylase"
EC:1.14.12.1	skos:altLabel	"anthranilate hydroxylase"
EC:1.14.12.1	skos:prefLabel	"anthranilate 1,2-dioxygenase (deaminating, decarboxylating)"
EC:1.14.12.1	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"anthranilate 1,2-dioxygenase (deaminating, decarboxylating)"
EC:1.14.12.1	skos:altLabel	"anthranilic acid hydroxylase"
REACT:R-CFA-5693564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of RAD51 with RAD52:DNA double-strand break ends (Canis familiaris)
REACT:R-XTR-9700121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PTN,MDK):PTPRZ oligomerizes (Xenopus tropicalis)
REACT:R-DRE-1855228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)
RHEA:54569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a uridine in rRNA => a pseudouridine in rRNA
GO:0080105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methylthiopropyl glucosinolate S-oxygenase activity
RHEA:64853	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-CoA + octan-1-ol => CoA + octyl benzoate
RHEA:62047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)
REACT:R-PFA-8951766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Plasmodium falciparum)
REACT:R-XTR-9664880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Xenopus tropicalis)
RHEA:71632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate(in) + sulfate(out) => phosphate(out) + sulfate(in)
REACT:R-HSA-167427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opioid dissociates from MOR (Homo sapiens)
REACT:R-CEL-8875490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPS15 and HGS bind ubiquitinated MET (Caenorhabditis elegans)
REACT:R-BTA-75244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL binds FAS Receptor (Bos taurus)
REACT:R-XTR-8985900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Xenopus tropicalis)
RHEA:43562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O
GO:0047974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine aminohydrolase activity
GO:0047974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine deaminase activity
GO:0047974	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine aminase activity
GO:0008756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	o-succinylbenzoate-CoA ligase activity
GO:0008756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-succinylbenzoyl-coenzyme A synthetase activity
GO:0008756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-succinylbenzoate:CoA ligase (AMP-forming)
GO:0008756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	o-succinylbenzoyl-CoA synthetase activity
GO:0008756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	OSB-CoA synthetase activity
GO:0008756	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-succinylbenzoate:CoA ligase (AMP-forming)
RHEA:45703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine betaine + H(+) + NADH + O2 <=> formaldehyde + H2O + N,N-dimethylglycine + NAD(+)
RHEA:64080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]
RHEA:67021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-HSA-8950271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sIL27RA translocates from the cytoplasm to the extracellular region (Homo sapiens)
REACT:R-XTR-110371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 binds APEX1 and PCNA at SSB (Xenopus tropicalis)
RHEA:11329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dimethylallyl diphosphate + isopentenyl diphosphate => diphosphate + neryl diphosphate
REACT:R-CFA-8938773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF144A polyubiquitinates PRKDC (Canis familiaris)
RHEA:10597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-tyrosyl-[protein] => ADP + H(+) + O-phospho-L-tyrosyl-[protein]
RHEA:29372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dAMP + H2O => 2'-deoxyadenosine + phosphate
REACT:R-DDI-110229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Dictyostelium discoideum)
GO:0004906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type II interferon receptor activity
GO:0004906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interferon-gamma receptor activity
GO:0004906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFN-gamma receptor activity
GO:0004906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IFNG receptor activity
RHEA:67557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + glycocholate => adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)
REACT:R-CEL-202626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with Co-Smad for R-Smad1/5/8 (Caenorhabditis elegans)
RHEA:71331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) = chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)
REACT:R-DRE-6797955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH7A1 oxidises BETALD to BET (Danio rerio)
RHEA:16793	skos:prefLabel	"phosphopantothenoylcysteine decarboxylase"
RHEA:16793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2
RHEA:16793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphopantothenoylcysteine decarboxylase"
RHEA:16793	skos:altLabel	"N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase"
REACT:R-BTA-6800794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIDD1 associates with CRADD (Bos taurus)
GO:0018571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-p-cumate-3,4-dioxygenase
GO:0018571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-p-cumate 3,4-dioxygenase
GO:0018571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxy-p-cumate dioxygenase activity
REACT:R-CFA-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
REACT:R-SSC-193653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF homodimer binds to p75NTR (Sus scrofa)
RHEA:53406	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
RHEA:37285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-alanine + L-histidine => H2O + L-alanyl-L-histidine
RHEA:34187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate
REACT:R-GGA-6810357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fillagrin and keratin intermediate filaments polymerise forming a network (Gallus gallus)
RHEA:18639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH => H2 + NADP(+)
REACT:R-XTR-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Xenopus tropicalis)
RHEA:23085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 7-methyl-3-oxooct-6-enoyl-CoA + acetate
REACT:R-DRE-4093339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)
REACT:R-DDI-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Dictyostelium discoideum)
REACT:R-CFA-74716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin binds the insulin receptor (Canis familiaris)
REACT:R-HSA-1482654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-MAG is transacylated to DAG by PNPLA2/3 (Homo sapiens)
REACT:R-DRE-917835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe3+ dissociates from holoTF:TFRC dimer (Danio rerio)
REACT:R-RNO-190520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Golgi  transport vesicles with microtubules (Rattus norvegicus)
RHEA:66507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:12210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methylumbelliferone + acetate + H(+) => 4-methylumbelliferyl acetate + H2O
RHEA:44370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide => Cr(6+) + 2 NADPH + O2
REACT:R-CFA-202710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MERTK receptor binds ligands (Gas6 or Protein S) (Canis familiaris)
RHEA:67921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)
REACT:R-SCE-6800138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Saccharomyces cerevisiae)
RHEA:20569	skos:altLabel	"canavanase"
RHEA:20569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-arginine = L-ornithine + urea
RHEA:20569	skos:altLabel	"arginine amidinase"
RHEA:20569	skos:prefLabel	"arginase"
RHEA:20569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"arginase"
GO:0019134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity
GO:0019134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosamine-1-phosphate N-acetyltransferase activity
GO:0019134	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity
REACT:R-DME-196060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Drosophila melanogaster)
REACT:R-PFA-69127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the Flap Intermediate (Plasmodium falciparum)
REACT:R-SPO-5444511	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH2:MSH3 Complex (Schizosaccharomyces pombe)
RHEA:23225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-trans-zeatin + UDP
GO:0052871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-tocopherol omega-hydroxylase activity
GO:0052871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-tocopherol 13-hydroxylase activity
REACT:R-MMU-9023884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCOA1 recruits EP300 to TGFA promoter (Mus musculus)
RHEA:60132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate
REACT:R-HSA-1602399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLB1 (Homo sapiens)
REACT:R-XTR-1369028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCAs mediate lipid efflux (Xenopus tropicalis)
REACT:R-DDI-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Dictyostelium discoideum)
REACT:R-BTA-913993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Bos taurus)
RHEA:17785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-glutamate = 4-aminobutanoate + CO2
RHEA:17785	skos:prefLabel	"glutamate decarboxylase"
RHEA:17785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glutamate decarboxylase"
RHEA:17785	skos:altLabel	"L-glutamate 1-carboxy-lyase"
REACT:R-MMU-170824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Mus musculus)
RHEA:46224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-feruloyl-CoA + H2O = (E)-ferulate + CoA + H(+)
RHEA:40936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)
RHEA:48924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine
REACT:R-BTA-8877760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Bos taurus)
REACT:R-XTR-74711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRS (Xenopus tropicalis)
REACT:R-BTA-210285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-homophilic interaction of PECAM-1 (Bos taurus)
RHEA:10742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ketone + H(+) + NADH => a secondary alcohol + NAD(+)
REACT:R-RNO-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Rattus norvegicus)
REACT:R-HSA-390595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Troponin-C (Homo sapiens)
REACT:R-XTR-8850527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDCL releases folded G-beta from TRiC/CCT (Xenopus tropicalis)
RHEA:32952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose => trehalulose
RHEA:70115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:40635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate
REACT:R-GGA-4755419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NR1H4 with SUMO1 (Gallus gallus)
RHEA:51142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2
GO:0004039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urea-1-carboxylate amidohydrolase activity
GO:0004039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allophanate hydrolase activity
GO:0004039	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	allophanate lyase activity
REACT:R-DME-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)
REACT:R-HSA-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Homo sapiens)
GO:0050231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	carbamoyl-phosphate:putrescine carbamoyltransferase activity
GO:0050231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	putrescine carbamoyltransferase activity
GO:0050231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PTCase activity
GO:0050231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine transcarbamylase activity
GO:0050231	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	putrescine synthase activity
REACT:R-HSA-400272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FBXL3 binds phosphorylated CRY proteins (Homo sapiens)
REACT:R-DRE-5357928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLIP3 and CYLD bind TNF signaling complex (Danio rerio)
REACT:R-SCE-266072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is hydolysed to LTB4 by LTA4H (Saccharomyces cerevisiae)
REACT:R-XTR-8940134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FOLR2 binds FOLA (Xenopus tropicalis)
GO:1905131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carcinine transmembrane transporter activity
RHEA:23376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonate + NAD(+) = 3-dehydro-D-erythronate + H(+) + NADH
RHEA:23376	skos:prefLabel	"L-threonate 3-dehydrogenase"
RHEA:23376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-threonate 3-dehydrogenase"
RHEA:23376	skos:altLabel	"L-threonic acid dehydrogenase"
RHEA:56697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate + L-tryptophan => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate
REACT:R-RNO-3295580	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRPM4,5 transport extracellular Na+ to cytosol (Rattus norvegicus)
REACT:R-SSC-5362549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np traffics to the plasma membrane (Sus scrofa)
REACT:R-GGA-418365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Gallus gallus)
REACT:R-CFA-425577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+-driven Cl-/HCO3- exchanger transport (Canis familiaris)
RHEA:66008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O
REACT:R-DDI-5696119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)
REACT:R-SSC-2032775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TEAD1 (Sus scrofa)
GO:0080072	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	spermidine:sinapoyl CoA N-acyltransferase activity
REACT:R-BTA-549129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT1 transports organic cations into hepatic cells (Bos taurus)
RHEA:15966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-DRE-209055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A dephosphorylates nuclear SMAD2/3 (Danio rerio)
REACT:R-XTR-5634104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-CRABP2:atRA translocates from cytosol to nucleus (Xenopus tropicalis)
RHEA:34104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate
RHEA:21097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydroquinate => 3-dehydroshikimate + H2O
RHEA:10079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lactose <=> beta-D-galactose + D-glucose
REACT:R-CEL-9018826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT2 hydrolyzes GTP (Caenorhabditis elegans)
REACT:R-HSA-8852167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRB2:Catecholamine binds ARRB1, ARRB2 (Homo sapiens)
REACT:R-MMU-2022887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NDST1-4 N-deacetylates GlcNAc residues in heparan (Mus musculus)
RHEA:63846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O => [thioredoxin]-dithiol + cumene hydroperoxide
RHEA:24229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) => 4-methylcatechol + CO2 + NADH
RHEA:38793	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
RHEA:71149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one => 3-hydroxyhispidin + O2
REACT:R-CFA-5649708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1,NEIL2 recruits POLB to incised AP site (Canis familiaris)
RHEA:25781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine => 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate
REACT:R-SCE-5218823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC phosphorylates sphingosine kinase 1 (Saccharomyces cerevisiae)
RHEA:35902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-MMU-4608854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 are recruited to the DVL2:PARD6A complex (Mus musculus)
REACT:R-SPO-2162078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Schizosaccharomyces pombe)
RHEA:50502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-alanyl-[protein]
RHEA:18390	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-xylose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-xylose
GO:0050735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-malonyltransferase activity
RHEA:61468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-BTA-420127	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CGRP receptor can bind calcitonin gene-related peptides (Bos taurus)
RHEA:64078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2
RHEA:10028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glutamate + H2O + O2 = 2-oxoglutarate + H2O2 + NH4(+)
REACT:R-SPO-77077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Capping complex formation (Schizosaccharomyces pombe)
RHEA:70986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine(out) + n H(+)(in) <=> glycine(in) + n H(+)(out)
RHEA:27405	skos:altLabel	"pyruvate oxidase"
RHEA:27405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2
RHEA:27405	skos:altLabel	"pyruvate dehydrogenase (cytochrome)"
RHEA:27405	skos:prefLabel	"pyruvate dehydrogenase (quinone)"
RHEA:27405	skos:altLabel	"pyruvate dehydrogenase"
RHEA:27405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"pyruvate dehydrogenase (quinone)"
REACT:R-RNO-4093329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNBs bind SDCBP (Rattus norvegicus)
REACT:R-BTA-2730842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K associates with phosphorylated GAB2 (Bos taurus)
REACT:R-HSA-8950533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Ras-related protein Ral-A (Homo sapiens)
RHEA:49400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + validoxylamine A 7'-phosphate = phosphate + validoxylamine A
RHEA:49400	skos:prefLabel	"validoxylamine A 7'-phosphate phosphatase"
RHEA:49400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"validoxylamine A 7'-phosphate phosphatase"
RHEA:45799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH
REACT:R-DME-192331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)
REACT:R-HSA-5686587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates RAD52 (Homo sapiens)
REACT:R-CFA-5676593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)
RHEA:72297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	malate(in) + 3 Na(+)(in) => malate(out) + 3 Na(+)(out)
REACT:R-RNO-437162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)
RHEA:54098	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
REACT:R-HSA-3769391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1 binds the beta-catenin:CBY complex (Homo sapiens)
REACT:R-GGA-5634228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF1 is cleaved by caspases (Gallus gallus)
REACT:R-HSA-9640480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2 enzyme UBE2N:UBE2V1 binds ubiquitin (Homo sapiens)
RHEA:33169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol => 2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)
REACT:R-XTR-9762091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Xenopus tropicalis)
REACT:R-SSC-2029466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)
RHEA:53821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + NADP(+) => 7-oxolithocholate + H(+) + NADPH
REACT:R-SSC-5679266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beclin-1 complex translocates to the ER (Sus scrofa)
REACT:R-RNO-450620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S193-KSRP binds 14-3-3zeta in the nucleus (Rattus norvegicus)
REACT:R-SSC-8852266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Sus scrofa)
REACT:R-SSC-5654705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
REACT:R-SSC-9024334	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Sus scrofa)
REACT:R-BTA-2161964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Bos taurus)
REACT:R-RNO-1482533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)
RHEA:44287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + 2 malonyl-CoA + octanoyl-CoA <=> 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA
RHEA:18178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2,3-saturated acyl-CoA + NAD(+) => a (2E)-enoyl-CoA + H(+) + NADH
RHEA:54467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate
RHEA:36967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA
RHEA:14484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
REACT:R-HSA-1483174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PE is methylated to PC by PEMT (Homo sapiens)
REACT:R-SSC-5607746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKC-delta is activated (Sus scrofa)
REACT:R-MMU-8850992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated PTEN (Mus musculus)
REACT:R-SSC-202723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha5beta1 binds FN1 dimer (Sus scrofa)
REACT:R-DME-3322429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP monoubiquinates TLE (Drosophila melanogaster)
REACT:R-CEL-416562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p190RhoGAP binds Plexin-B1 (Caenorhabditis elegans)
RHEA:12090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-glucose
REACT:R-RNO-432143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PECAM-1 binds PP2A (Rattus norvegicus)
REACT:R-SSC-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
REACT:R-GGA-5691107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Gallus gallus)
REACT:R-SPO-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Schizosaccharomyces pombe)
REACT:R-CFA-8982645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRKs bind ADRB2:Catecholamine (Canis familiaris)
RHEA:53174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O
RHEA:64907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + 2 H2O <=> GMP + 2 H(+) + 2 phosphate
REACT:R-SCE-9620103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH2 transforms GTN to NO (Saccharomyces cerevisiae)
REACT:R-XTR-936380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of PIN1 with p-IRF3 (Xenopus tropicalis)
RHEA:47432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-RNO-6794347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Homer1,2,3 dimerizes (Rattus norvegicus)
REACT:R-RNO-74730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Insulin degradation (Rattus norvegicus)
RHEA:71160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-serine(out) + Na(+)(out) => H(+)(out) + L-serine(in) + Na(+)(in)
REACT:R-CFA-179421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of multiubiquitinated Nek2A (Canis familiaris)
RHEA:68402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + gamma-gurjunene => (2E,6E)-farnesyl diphosphate
REACT:R-BTA-349657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)
REACT:R-RNO-187937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Rattus norvegicus)
REACT:R-XTR-9614933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACEIs bind ACE (Xenopus tropicalis)
RHEA:27785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + all-trans-octaprenyl diphosphate <=> 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate
REACT:R-CFA-977615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates MCP/CR1-bound C4b/C3b (Canis familiaris)
REACT:R-XTR-5357472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1-3 autophosphorylates (Xenopus tropicalis)
RHEA:16344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-5-phosphomevalonate + ATP <=> (R)-5-diphosphomevalonate + ADP
RHEA:23628	skos:altLabel	"beta-acetylglucosaminylsaccharide fucosyltransferase"
RHEA:23628	skos:altLabel	"FucT-II"
RHEA:23628	skos:altLabel	"Lewis blood group alpha-(1->3/4)-fucosyltransferase"
RHEA:23628	skos:altLabel	"guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase"
RHEA:23628	skos:prefLabel	"3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase"
RHEA:23628	skos:altLabel	"Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase"
RHEA:23628	skos:altLabel	"alpha-(1->4)-L-fucosyltransferase"
RHEA:23628	skos:altLabel	"guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase"
RHEA:23628	skos:altLabel	"Lewis alpha-(1->3/4)-fucosyltransferase"
RHEA:23628	skos:altLabel	"blood-group substance Le(a)-dependent fucosyltransferase"
RHEA:23628	skos:altLabel	"(Le(a))-dependent (alpha-3/4)-fucosyltransferase"
RHEA:23628	skos:altLabel	"alpha(1,3/1,4) fucosyltransferase III"
RHEA:23628	skos:altLabel	"guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase"
RHEA:23628	skos:altLabel	"blood group Lewis alpha-4-fucosyltransferase"
RHEA:23628	skos:altLabel	"alpha-4-L-fucosyltransferase"
RHEA:23628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)
RHEA:23628	skos:altLabel	"Lewis FT"
RHEA:23628	skos:altLabel	"galactoside 3(4)-L-fucosyltransferase"
RHEA:23628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase"
RHEA:33543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ergosteryl palmitate + H2O = ergosterol + H(+) + hexadecanoate
REACT:R-DME-1606312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-galactosidase can also hydrolyse globosides to form cerebrosides (Drosophila melanogaster)
REACT:R-HSA-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Homo sapiens)
REACT:R-DME-5250531	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARV1 transports CHOL from ER membrane to plasma membrane (Drosophila melanogaster)
RHEA:65940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-glycerate + GDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)
RHEA:20179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-O-beta-D-glucosylpyridoxine + H(+) + UDP => pyridoxine + UDP-alpha-D-glucose
RHEA:23271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + H2O <=> glycine + urea
GO:0035241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein arginine omega-N monomethylase activity
GO:0035241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine
GO:0035241	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega-methyl-L-arginine-forming)
GO:0035241	skos:prefLabel	"type III protein arginine methyltransferase"
GO:0035241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"type III protein arginine methyltransferase"
GO:0035241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine omega-N monomethyltransferase activity
GO:0035241	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	type III protein arginine methyltransferase activity
REACT:R-MMU-2534359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CatSper Channel Mediated Calcium Transport (Mus musculus)
REACT:R-BTA-8855648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM3 binds LAR-RPTP (Bos taurus)
REACT:R-SSC-2161779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LXA4 is oxidised to 15k-LXA4 by HPGD (Sus scrofa)
RHEA:70533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-DME-73620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)
REACT:R-MMU-975916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to position 5 by MGAT5 (Mus musculus)
REACT:R-RNO-8851396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase6 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
RHEA:63774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine
RHEA:41866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	decanoyl-[ACP] + NADP(+) => (2E)-decenoyl-[ACP] + H(+) + NADPH
RHEA:60411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine
REACT:R-DME-5654615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:pFRS binds GRB2:SOS1 (Drosophila melanogaster)
RHEA:65997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) => methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine
REACT:R-DRE-194310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Danio rerio)
REACT:R-MMU-9029566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Mus musculus)
REACT:R-BTA-877281	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 binds p-STAT1 dimer (Bos taurus)
REACT:R-XTR-5638141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)
REACT:R-XTR-873917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of STAT1 dimer to nucleus (Xenopus tropicalis)
RHEA:25073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoate + ATP + CoA <=> 3-hydroxybenzoyl-CoA + AMP + diphosphate
GO:0047041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-carnitine:NAD+ oxidoreductase activity
GO:0047041	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-carnitine dehydrogenase activity
GO:0047041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-carnitine 3-dehydrogenase activity
RHEA:57589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:71063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-histidine(out) = L-arginine(out) + L-histidine(in)
EC:4.98.1.-	skos:prefLabel	"Forming coordination complexes"
EC:4.98.1.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Forming coordination complexes"
REACT:R-HSA-178178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP1 dephosphorylates TGFBR1 (Homo sapiens)
REACT:R-RNO-451311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca-permeable Kainate receptors (Rattus norvegicus)
RHEA:34391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase"
RHEA:34391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose = [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP
RHEA:34391	skos:prefLabel	"galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase"
RHEA:11238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propane-1,3-diamine + sym-homospermidine => putrescine + spermidine
RHEA:63845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-dithiol + cumene hydroperoxide => 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O
REACT:R-SPO-5618107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP binding to HSP90 triggers conformation change (Schizosaccharomyces pombe)
RHEA:13864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylose + NAD(+) <=> D-xylono-1,5-lactone + H(+) + NADH
RHEA:25423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O <=> 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate
REACT:R-CEL-8931858	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Caenorhabditis elegans)
RHEA:40369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP
REACT:R-DRE-8857555	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR phosphorylates GPNMB (Danio rerio)
REACT:R-MMU-9654525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Mus musculus)
RHEA:10842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonine + phosphate => H2O + O-phospho-L-homoserine
GO:0050525	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	cutin hydrolase activity
GO:0050525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cutinase activity
REACT:R-BTA-6814674	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Bos taurus)
REACT:R-DME-77299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)
RHEA:44488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
REACT:R-DDI-9686969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	APC/C:Cdh1 polyubiquitinates SKP2 (Dictyostelium discoideum)
RHEA:15968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
REACT:R-MMU-994140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Mus musculus)
GO:0050061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain aliphatic aldehyde dehydrogenase activity
GO:0050061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain-aldehyde:NAD+ oxidoreductase activity
GO:0050061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	long-chain fatty aldehyde dehydrogenase activity
GO:0050061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	long-chain-aldehyde dehydrogenase activity
GO:0050061	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fatty aldehyde:NAD+ oxidoreductase activity
REACT:R-CFA-9696271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND1 binds effectors (Canis familiaris)
RHEA:52259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine
REACT:R-CFA-6813626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LEAP2 binds bacteria (Canis familiaris)
RHEA:20099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-dehydro-3-deoxy-D-gluconate + H2O => D-mannonate
RHEA:33672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2
REACT:R-SSC-264758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Sus scrofa)
REACT:R-BTA-2032770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of YAP1 to the nucleus (Bos taurus)
REACT:R-RNO-5654663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)
RHEA:67601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O(6)-methyl-dGTP => diphosphate + H(+) + O(6)-methyl-dGMP
RHEA:38474	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine + 3 S-adenosyl-L-methionine <=> 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine
RHEA:66656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)
RHEA:24562	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-acetyl-L-serine => acetyl-CoA + L-serine
REACT:R-DRE-71732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
RHEA:56767	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 <=> 12-epi-fischerindole G + CO2 + H2O + succinate
REACT:R-RNO-9629470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Rattus norvegicus)
REACT:R-HSA-381217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)
RHEA:58126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-9731009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-1 nsp3 binds to IRF3 (Homo sapiens)
RHEA:57411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH
REACT:R-DRE-416546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Danio rerio)
GO:0140838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity
REACT:R-RNO-391151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-4Y-SIRPA:CD47:SKAP2 binds FYB (Rattus norvegicus)
RHEA:33730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine <=> a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)
RHEA:70621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine
RHEA:37443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
REACT:R-DDI-1028788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Dictyostelium discoideum)
REACT:R-RNO-77590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of CstF to the CPSF Bound Pre-mRNA (Rattus norvegicus)
REACT:R-RNO-9006873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL21 receptor STAT binding (Rattus norvegicus)
REACT:R-BTA-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Bos taurus)
REACT:R-BTA-9020255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Bos taurus)
REACT:R-DRE-9629675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE3A hydrolyses cAMP to AMP (Danio rerio)
RHEA:39157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octadecenoyl-CoA + H2O => (3R)-hydroxyoctadecanoyl-CoA
GO:0047902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formylaspartate deformylase activity
GO:0047902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formyl-L-aspartate = formate + L-aspartate
GO:0047902	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-formyl-L-aspartate amidohydrolase activity
GO:0047902	skos:prefLabel	"formylaspartate deformylase"
GO:0047902	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formylaspartic formylase (formylase I, formylase II)
GO:0047902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formylaspartate deformylase"
REACT:R-RNO-9018815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOT1 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)
REACT:R-XTR-9632873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S10 CDKN1B translocates to the cytosol (Xenopus tropicalis)
REACT:R-BTA-158419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)
REACT:R-DME-429978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Lsm1-7 Complex binds deadenylated mRNA (Drosophila melanogaster)
REACT:R-CEL-200735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Caenorhabditis elegans)
RHEA:70367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxosphinganine + octanoyl-CoA = CoA + H(+) + N-octanoyl-3-oxosphinganine
REACT:R-SSC-8944236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIV (Sus scrofa)
GO:0102436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-methylmyricetin 4'-O-methyltransferase activity
RHEA:37479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-CFA-5689544	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UCHL5 binds INO80 complex (Canis familiaris)
REACT:R-CFA-416594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LARG and PDZ-RhoGEF binds to Plexin-B1 (Canis familiaris)
REACT:R-DRE-75900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Danio rerio)
RHEA:62304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine = (+)-premalbrancheamide
EC:2.3.1.87	skos:altLabel	"serotonin N-acetyltransferase"
EC:2.3.1.87	skos:altLabel	"AANAT"
EC:2.3.1.87	skos:altLabel	"arylalkylamine N-acetyltransferase"
EC:2.3.1.87	skos:prefLabel	"aralkylamine N-acetyltransferase"
EC:2.3.1.87	skos:altLabel	"melatonin rhythm enzyme"
EC:2.3.1.87	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aralkylamine N-acetyltransferase"
EC:2.3.1.87	skos:altLabel	"serotonin acetylase"
EC:2.3.1.87	skos:altLabel	"serotonin acetyltransferase"
REACT:R-HSA-9625479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRF and ELK1 bind the FOS gene (Homo sapiens)
REACT:R-HSA-9614787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPZ gene expression (Homo sapiens)
RHEA:32190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholest-5-en-3-one <=> cholest-4-en-3-one
RHEA:10702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	limonene-1,2-diol => H2O + limonene 1,2-epoxide
GO:0102090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adrenaline O-methyltransferase activity
RHEA:25241	skos:prefLabel	"(S)-ureidoglycine aminohydrolase"
RHEA:25241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-ureidoglycine aminohydrolase"
RHEA:25241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4(+)
REACT:R-SPO-200651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Schizosaccharomyces pombe)
GO:0050317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:D-tagatose 6-phosphotransferase activity
GO:0050317	skos:prefLabel	"tagatose kinase"
GO:0050317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-tagatose 6-phosphate kinase activity
GO:0050317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tagatose kinase activity
GO:0050317	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tagatose 6-phosphate kinase (phosphorylating)
GO:0050317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + keto-D-tagatose = ADP + H(+) + keto-D-tagatose 6-phosphate
GO:0050317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tagatose kinase"
REACT:R-DDI-1011598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCKs bind to RhoGEFs (Dictyostelium discoideum)
REACT:R-XTR-170149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of active Cdc25C to the nucleus (Xenopus tropicalis)
REACT:R-CEL-9756177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)
REACT:R-CFA-388831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CD28 (Canis familiaris)
GO:0019208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatase regulator activity
REACT:R-GGA-5654640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)
RHEA:33676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) => H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2
REACT:R-DDI-8979996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPs hydrolyze TG to DAG and LCFA (Dictyostelium discoideum)
REACT:R-XTR-5625797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Xenopus tropicalis)
REACT:R-GGA-6798044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BTG2 binds CCR4-NOT complex (Gallus gallus)
RHEA:41517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]
REACT:R-CFA-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Canis familiaris)
RHEA:50563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]
REACT:R-SSC-8987132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Sus scrofa)
GO:0047157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myelin-proteolipid O-palmitoyltransferase activity
GO:0047157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	myelin PLP acyltransferase activity
GO:0047157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	[myelin-proteolipid] O-palmitoyltransferase activity
GO:0047157	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity
GO:0047157	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acyl-protein synthase activity
RHEA:28136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-hesperetin + rutinose => (2S)-hesperidin + H2O
RHEA:36005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	propanal + pyruvate => (S)-4-hydroxy-2-oxohexanoate
RHEA:18753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH
RHEA:17579	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP-L-glycero-beta-D-manno-heptose => ADP-D-glycero-beta-D-manno-heptose
RHEA:37169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesal + H(+) + NADH => (2E,6E)-farnesol + NAD(+)
REACT:R-HSA-8944483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	miR-17 microRNA binds PTEN mRNA (Homo sapiens)
REACT:R-XTR-2161792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)
RHEA:21921	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP
GO:0042016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-20 receptor activity
GO:0042016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-20 receptor activity
GO:0042016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL-20R
REACT:R-BTA-77342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Bos taurus)
RHEA:69678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eriodictyol-7-O-beta-D-glucoside + H2O <=> (S)-eriodictyol + beta-D-glucose
RHEA:59923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenal + H2O + NAD(+) <=> (2E)-octenoate + 2 H(+) + NADH
GO:0047645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkan-1-ol:(acceptor) oxidoreductase activity
GO:0047645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	polyethylene glycol dehydrogenase activity
GO:0047645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alkan-1-ol dehydrogenase (acceptor) activity
GO:0047645	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	alkan-1-ol:acceptor oxidoreductase activity
REACT:R-CFA-8985988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Canis familiaris)
RHEA:51214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+)
GO:0036121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded DNA helicase activity
GO:0036121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded DNA-dependent ATPase activity
GO:0036121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	double-stranded DNA-dependent ATP-dependent DNA helicase activity
GO:0036121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dsDNA-dependent ATP-dependent DNA helicase activity
GO:0036121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dsDNA-dependent ATPase activity
REACT:R-GGA-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Gallus gallus)
REACT:R-BTA-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Bos taurus)
GO:0033930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	keratan-sulfate 1,4-beta-D-galactanohydrolase activity
GO:0033930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	keratan-sulfate endo-1,4-beta-galactosidase activity
GO:0033930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	keratan sulfate endogalactosidase activity
GO:0033930	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	keratanase activity
GO:0033930	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	endo-beta-galactosidase activity
REACT:R-CEL-5358484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Caenorhabditis elegans)
RHEA:34718	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine + ATP <=> 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)
REACT:R-RNO-375140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds promyogenic cadherins (Rattus norvegicus)
RHEA:25590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-oxalosuccinate + H(+) + NADPH => D-threo-isocitrate + NADP(+)
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	p-hydroxybenzoate glucosyltransferase activity
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HBA glucosyltransferase activity
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxybenzoate 4-O-beta-D-glucosyltransferase"
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PHB-O-glucosyltransferase activity
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxybenzoate + UDP-alpha-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP
GO:0047250	skos:prefLabel	"4-hydroxybenzoate 4-O-beta-D-glucosyltransferase"
GO:0047250	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PHB glucosyltransferase activity
REACT:R-SSC-9755505	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Sus scrofa)
REACT:R-BTA-1250383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)
RHEA:36365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+) => (9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH
REACT:R-RNO-3000103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUBN:AMN binds CBLIF:RCbl (Rattus norvegicus)
GO:0031764	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	type 1 galanin receptor ligand
GO:0031764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	type 1 galanin receptor binding
REACT:R-RNO-9731228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)
RHEA:37937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate
RHEA:34719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-methylhexadecasphing-4-enine 1-phosphate = (2E)-13-methyltetradecenal + phosphoethanolamine
REACT:R-SCE-71037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Saccharomyces cerevisiae)
RHEA:18294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + oxalate => AMP + diphosphate + oxalyl-CoA
REACT:R-CEL-751019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The Ligand:GPCR:G12/13 complex dissociates (Caenorhabditis elegans)
RHEA:71427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)
RHEA:35499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"11-oxo-beta-amyrin 30-oxidase"
RHEA:35499	skos:altLabel	"CYP72A154"
RHEA:35499	skos:prefLabel	"11-oxo-beta-amyrin 30-oxidase"
RHEA:35499	skos:altLabel	"CYP72A"
RHEA:35499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
RHEA:35499	skos:altLabel	"11-oxo-beta-amyrin 30-monooxygenase"
REACT:R-BTA-1855207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Bos taurus)
REACT:R-MMU-8937369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAD2 binds ESR1 (Mus musculus)
GO:0008859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	exoribonuclease II activity
GO:0008859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	RNase II
GO:0008859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	BN ribonuclease activity
GO:0008859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease II activity
GO:0008859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5'-exoribonuclease activity
GO:0008859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Escherichia coli exo-RNase II
GO:0008859	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ribonuclease Q
GO:0008859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNase II activity
REACT:R-HSA-5637770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)
RHEA:55059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
REACT:R-XTR-389622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)
REACT:R-SSC-2468040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cohesin binds PDS5 and WAPAL (Sus scrofa)
REACT:R-CEL-8877475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAPPC complexes exchange GTP for GDP on RAB1 (Caenorhabditis elegans)
REACT:R-CFA-508189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Canis familiaris)
REACT:R-BTA-5685608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC2B binds KLRF1 dimer (Bos taurus)
RHEA:23777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartate => 4-phospho-L-aspartate + ADP
RHEA:37537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine
RHEA:61697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycine + holo-[peptidyl-carrier protein] => AMP + diphosphate + glycyl-[peptidyl-carrier protein]
RHEA:69030	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-androstane-3alpha,17beta-diol + NADP(+) => 5beta-dihydrotestosterone + H(+) + NADPH
REACT:R-HSA-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Homo sapiens)
REACT:R-GGA-444731	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Gallus gallus)
RHEA:29404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 => 3-demethylubiquinol-8 + A + H2O
RHEA:55060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:72648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine + NADPH + O2 => 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)
RHEA:63006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11Z,14Z)-eicosadienoate + NH4(+) => (11Z,14Z)-eicosadienamide + H2O
RHEA:71764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate(out) + citrate(in) => 2-oxoglutarate(in) + citrate(out)
REACT:R-DDI-548831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Dictyostelium discoideum)
REACT:R-SCE-189488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UROS transforms HMB to URO3 (Saccharomyces cerevisiae)
RHEA:67867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] <=> 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)
GO:0033748	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogen-lyase activity
GO:0033748	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:(acceptor) oxidoreductase activity
GO:0033748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogenase (acceptor) activity
GO:0033748	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	uptake hydrogenase activity
GO:0033748	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	hydrogenlyase activity
GO:0033748	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydrogen:acceptor oxidoreductase activity
GO:0033748	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	H2 producing hydrogenase activity
RHEA:42856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate
REACT:R-MMU-8854612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBC1D25 accelerates GTP hydrolysis by RAB33B (Mus musculus)
REACT:R-CFA-139898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 activates BID by cleavage (Canis familiaris)
GO:0033705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Rmd
GO:0033705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity
GO:0033705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-6-deoxy-D-mannose reductase activity
GO:0033705	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GDP-6-deoxy-D-lyxo-4-hexulose reductase activity
GO:0033705	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	GDP-4-keto-6-deoxy-D-mannose reductase activity
GO:0034951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	o-hydroxylaminobenzoate mutase activity
REACT:R-BTA-9032798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK3 activates RAC1 (Bos taurus)
RHEA:28301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate
REACT:R-DME-8871370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 translocates from cytosol to early endosome membrane (Drosophila melanogaster)
REACT:R-RNO-72647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cap-bound mRNA is activated by helicases  (Rattus norvegicus)
REACT:R-RNO-9728723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Rattus norvegicus)
REACT:R-XTR-6801195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STEAP3 binds BNIP3L (Xenopus tropicalis)
REACT:R-MMU-8876454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DENND3 exchanges GTP for GDP on RAB12 (Mus musculus)
REACT:R-DDI-5687112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK6 is degraded by the 26S proteasome (Dictyostelium discoideum)
REACT:R-MMU-5221130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Mus musculus)
RHEA:69107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxo-3-sulfanylpropanoate + L-kynurenine <=> H2O + kynurenate + L-cysteine
REACT:R-DRE-174657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Danio rerio)
REACT:R-SSC-112034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Sus scrofa)
RHEA:47868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-(9Z)-octadecenoylglycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)
REACT:R-DRE-6809325	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)
REACT:R-HSA-2161950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Homo sapiens)
REACT:R-RNO-5687126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S215 FOXO3 translocates to the nucleus (Rattus norvegicus)
REACT:R-MMU-209061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Mus musculus)
RHEA:15699	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase] => liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]
GO:0010355	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	homogentisate farnesyltransferase activity
REACT:R-DME-211950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP24A1 24-hydroxylates CTL (Drosophila melanogaster)
RHEA:24903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',3'-c-di-GMP + H2O => 5'-phosphoguanylyl(3'->5')guanosine + H(+)
REACT:R-HSA-9669874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sorafenib-resistant KIT mutants do not bind sorafenib (Homo sapiens)
REACT:R-HSA-8864426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A,TFAP2C homodimers bind the CGB gene promoter (Homo sapiens)
REACT:R-DRE-688136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates RIP2 (Danio rerio)
RHEA:17015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphonopyruvate => H(+) + phosphoenolpyruvate
REACT:R-DME-5687640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Drosophila melanogaster)
GO:0062206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	manoyl oxide synthase activity
RHEA:63697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SN-38 + UDP-alpha-D-glucuronate => H(+) + SN-38 O-beta-D-glucuronide + UDP
REACT:R-SSC-5690870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Sus scrofa)
RHEA:62984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + hexadecanamide = hexadecanoate + NH4(+)
REACT:R-BTA-9007901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 binds IL1RL2 (Bos taurus)
REACT:R-RNO-9629149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL1 cleaves thymine glycol from damaged DNA (Rattus norvegicus)
REACT:R-HSA-1368889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of NAMPT (NamPRT, PBEF, Visfatin) (Homo sapiens)
RHEA:49288	skos:prefLabel	"lipoate--protein ligase"
RHEA:49288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)
RHEA:49288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipoate--protein ligase"
RHEA:49288	skos:altLabel	"LPL"
RHEA:49288	skos:altLabel	"lipoate protein ligase"
RHEA:49288	skos:altLabel	"lipoate-protein ligase A"
REACT:R-CFA-390598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Myosin Binds ATP (Canis familiaris)
RHEA:54086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	archaeosine(15) in tRNA + L-glutamate => 7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine
REACT:R-CFA-5685838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CX3 complex binds D-loop structures (Canis familiaris)
REACT:R-XTR-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Xenopus tropicalis)
REACT:R-RNO-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Rattus norvegicus)
GO:0034856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexa-2,4-dienoate hydratase activity
REACT:R-SSC-444620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide S receptor binds neuropeptide S (Sus scrofa)
RHEA:19080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate
REACT:R-SSC-193816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Sus scrofa)
REACT:R-CEL-8850560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha releases G-protein heterotrimer from PDCL  (Caenorhabditis elegans)
REACT:R-BTA-201035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)
REACT:R-BTA-8874470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Bos taurus)
RHEA:27893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-UMP + H2O <=> phosphate + uridine
REACT:R-XTR-6805573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Keratin type I/type II heterodimers form tetramers (Xenopus tropicalis)
REACT:R-RNO-1971491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Rattus norvegicus)
GO:0009669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose:monovalent cation symporter activity
GO:0009669	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sucrose permease activity
GO:0009669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sucrose:cation symporter activity
REACT:R-HSA-6785213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPC dimer binds heparin (Homo sapiens)
REACT:R-DRE-5423637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR dimers reduce AFBDHO to AFBDOH (Danio rerio)
GO:0047415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-BAPA-ase activity
GO:0047415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzoyl-D-arginine arylamidase activity
GO:0047415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-benzoylarginine-4-nitroanilide amidase activity
GO:0047415	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity
REACT:R-DRE-449117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TXLNA (IL14) binds syntaxin1A (Danio rerio)
GO:0030768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity
GO:0030768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity
GO:0030768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NMT activity
GO:0030768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity
GO:0030768	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity
GO:0030768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity
REACT:R-SSC-8956184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Sus scrofa)
RHEA:43034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminoprop-2-enoate + chloride + H(+) => 3-chloro-D-alanine
RHEA:44889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)
RHEA:12093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-acetoin => (R)-acetoin
REACT:R-MMU-2213208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type X collagen associates with collagen type II fibrils (Mus musculus)
REACT:R-DDI-162742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Dictyostelium discoideum)
REACT:R-CFA-2187382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD3 (Canis familiaris)
REACT:R-RNO-5683077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF8 and RNF168 ubiquitinate KDM4A,B (Rattus norvegicus)
REACT:R-RNO-1362270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of LIN52 component of MuvB by DYRK1A (Rattus norvegicus)
RHEA:57784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite
REACT:R-BTA-5218814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 autophorylates (Bos taurus)
REACT:R-XTR-983152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of ubiquitin from E1 to E2 (Xenopus tropicalis)
REACT:R-DDI-9020616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG12 forms a thioester bond with ATG7 dimer (Dictyostelium discoideum)
REACT:R-CFA-392295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gbeta:gamma recruits PI3K gamma (Canis familiaris)
GO:1901236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylamino)butanoate(in) = 4-(trimethylamino)butanoate(out)
GO:1901236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(trimethylammonio)butanoate transmembrane transporter activity
REACT:R-BTA-1678920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TLR processing at low pH (Bos taurus)
REACT:R-DDI-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Dictyostelium discoideum)
REACT:R-SSC-8849085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARHGAP35 binds RHOA:GTP (Sus scrofa)
REACT:R-HSA-8942208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOXE3 isomerises 12R-HpETE to HXA3 (Homo sapiens)
RHEA:53833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 => a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate
REACT:R-BTA-9611751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	β1,2-agonists bind ADRB1,2 (Bos taurus)
REACT:R-CFA-9012721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Canis familiaris)
REACT:R-RNO-2309773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGG2 is reduced to PGH2 by PTGS2 (Rattus norvegicus)
REACT:R-RNO-9661419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds extracellular heme (Rattus norvegicus)
RHEA:29295	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-galacturonate(out) + H(+)(out) = aldehydo-D-galacturonate(in) + H(+)(in)
GO:0102619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oryzalexin C synthase (oryzalexin A dependent) activity
RHEA:22703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:49267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-O-[(E)-caffeoyl]-shikimate + H2O <=> (E)-caffeate + H(+) + shikimate
REACT:R-XTR-9734713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC6 translocates to the nucleus (Xenopus tropicalis)
REACT:R-GGA-9657603	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
RHEA:35052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N,N'-diacetylchitobiose(out) => N,N'-diacetylchitobiose(in)
REACT:R-RNO-1482636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)
RHEA:53961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O
REACT:R-GGA-2682349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Gallus gallus)
REACT:R-DME-879594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO4C1 mediates the transport of digoxin (Drosophila melanogaster)
REACT:R-BTA-170846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TGFBR2 recruits TGFBR1 (Bos taurus)
RHEA:29245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + NAD(+) => H(+) + menaquinone-8 + NADH
REACT:R-GGA-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Gallus gallus)
RHEA:48297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin E2 1-glyceryl ester => glycerol + H(+) + prostaglandin E2
REACT:R-DME-5635842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3 phosphorylates GLI (Drosophila melanogaster)
REACT:R-CEL-1168376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STIM1 oligomerizes (Caenorhabditis elegans)
GO:0000702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidized base lesion DNA N-glycosylase activity
GO:0005365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myo-inositol transmembrane transporter activity
GO:0005365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vitamin Bh transporter activity
RHEA:21003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene <=> 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene
REACT:R-HSA-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)
RHEA:54056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2E,6E)-hedycaryol synthase"
RHEA:54056	skos:prefLabel	"(2E,6E)-hedycaryol synthase"
RHEA:54056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-hedycaryol + diphosphate
GO:0047047	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloglycolate reductase (decarboxylating) activity
GO:0047047	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	D-glycerate:NAD(P)+ oxidoreductase (carboxylating)
REACT:R-GGA-9692539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds HRH1 inverse agonists (Gallus gallus)
RHEA:26440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoate + H(+) + NADPH => 3-hydroxypropanoate + NADP(+)
REACT:R-MMU-5690991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Mus musculus)
RHEA:72272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	formate(out) + oxalate(in) => formate(in) + oxalate(out)
REACT:R-BTA-109862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K2 phosphorylates MAPK1 (Bos taurus)
RHEA:26432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + phyllocladan-16alpha-ol => (+)-copalyl diphosphate + H2O
GO:0004477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methenyltetrahydrofolate cyclohydrolase activity
GO:0004477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citrovorum factor cyclodehydrase activity
GO:0004477	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyl-THF cyclohydrolase activity
GO:0004477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
GO:0004477	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formyl-methenyl-methylenetetrahydrofolate synthetase (combined)
GO:0070139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMO-specific endopeptidase activity
GO:0070139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO3 (Homo sapiens)
REACT:R-XTR-8876319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC50A1 transports Glc from cytosol to extracellular region (Xenopus tropicalis)
RHEA:62690	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O + 2 ustilaginoidin A => 4 norrubrofusarin + O2
RHEA:30537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biotin + H2O + NADP(+) => biotinate sulfoxide + H(+) + NADPH
RHEA:51672	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxal + H2O = glycolate + H(+)
RHEA:53664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) = H(+) + 2 H2O + pyridinestrone carboxylate
RHEA:62451	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP <=> AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]
REACT:R-CFA-2161961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EET(1) is hydrolysed to DHET(1) by EPHX2 (Canis familiaris)
REACT:R-RNO-5173005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	B3GALTL transfers glucose to O-fucosyl-proteins (Rattus norvegicus)
REACT:R-HSA-193964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 21-hydroxylates PROG (Homo sapiens)
RHEA:38590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucose + vancomycin aglycone <=> devancoaminyl-vancomycin + UDP
RHEA:18560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA <=> 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA
RHEA:36560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + cis-4-hydroxy-D-proline => 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)
REACT:R-GGA-9647994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS proteins are depalmitoylated (Gallus gallus)
RHEA:52599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholoyl-CoA + NAD(+) <=> 3-oxocholan-24-oyl-CoA + H(+) + NADH
RHEA:70830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) + L-lysine(out) <=> L-arginine(out) + L-lysine(in)
EC:2.4.1.147	skos:altLabel	"Core 3beta-GlcNAc-transferase"
EC:2.4.1.147	skos:altLabel	"O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III"
EC:2.4.1.147	skos:prefLabel	"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase"
EC:2.4.1.147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase"
REACT:R-XTR-5672948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MARK3 phosphorylates KSR1 (Xenopus tropicalis)
REACT:R-CFA-192036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Canis familiaris)
REACT:R-SSC-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Sus scrofa)
REACT:R-DME-9638125	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGM1:Mg2+ isomerises G1P to G6P (Drosophila melanogaster)
RHEA:63747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan-1-N-beta-D-glucuronide
RHEA:38416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)
REACT:R-CEL-3247847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WLS is endocytosed to the early endosome (Caenorhabditis elegans)
RHEA:14204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-lyxose <=> D-xylulose
RHEA:44862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + O-4,8-dimethylnonanoyl-(R)-carnitine => (R)-carnitine + 4,8-dimethylnonanoyl-CoA
RHEA:72482	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	citrate(out) + trans-aconitate(in) <=> citrate(in) + trans-aconitate(out)
REACT:R-CFA-5662662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tyrosinase oxidises tyrosine to dopaquinone (Canis familiaris)
REACT:R-CEL-1604368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic activation of bound proMMP2 (Caenorhabditis elegans)
REACT:R-CFA-1183128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Canis familiaris)
REACT:R-DRE-389891	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Danio rerio)
REACT:R-SSC-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Sus scrofa)
REACT:R-RNO-140216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of PMAIP1 (NOXA) to mitochondria (Rattus norvegicus)
REACT:R-SSC-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Sus scrofa)
REACT:R-GGA-844438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NLRP1 oligomerizes (Gallus gallus)
REACT:R-RNO-1362485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GHBP binds GH (Rattus norvegicus)
REACT:R-RNO-9759209	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LRP2 binds extracellular TCN2:RCbl (Rattus norvegicus)
RHEA:43910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-galactose + sphing-4-enine => beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O
REACT:R-CEL-5205673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 binds ubiquitinated mitochondrial substrates (Caenorhabditis elegans)
REACT:R-XTR-6807055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCR7 reduces 7-dehydroCHOL to CHOL (Xenopus tropicalis)
RHEA:11956	skos:prefLabel	"steryl-beta-glucosidase"
RHEA:11956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + sitosteryl 3-beta-D-glucoside = D-glucose + sitosterol
RHEA:11956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
RHEA:11956	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"steryl-beta-glucosidase"
REACT:R-CEL-201636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoplakin (Caenorhabditis elegans)
REACT:R-GGA-874087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SGT1 binds HSP90 (Gallus gallus)
REACT:R-SSC-5675456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)
RHEA:30176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15-cis-phytoene + 2 plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9
REACT:R-GGA-8950179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL12B translocates from the cytosol to the extracellular region (Gallus gallus)
REACT:R-BTA-204824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Ang4 (Bos taurus)
REACT:R-HSA-2022056	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSPG and CSPG translocate to the lysosome for degradation (Homo sapiens)
REACT:R-HSA-3928614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EFNB:GRB4 binds GIT1 (Homo sapiens)
REACT:R-HSA-389897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Homo sapiens)
REACT:R-RNO-157849	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of translation initiation complexes containing mRNA that does not circularize (Rattus norvegicus)
REACT:R-HSA-193519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)
REACT:R-XTR-5635842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3 phosphorylates GLI (Xenopus tropicalis)
REACT:R-BTA-8953111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F6 binds TFDP1 (Bos taurus)
RHEA:61194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]
REACT:R-GGA-1471322	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins are secreted (Gallus gallus)
REACT:R-CFA-434382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Canis familiaris)
REACT:R-RNO-3785711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Telomere shortening during replicative exhaustion (Rattus norvegicus)
RHEA:62885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + 4 semiviriditoxin => 2 (M)-viriditoxin + 2 H2O
REACT:R-CFA-8877691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2K6 phosphorylates PIP4K2B (Canis familiaris)
REACT:R-HSA-6805620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KAT6A and PML bind TP53 (Homo sapiens)
RHEA:32170	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> aerobactin + AMP + diphosphate + H(+)
RHEA:14838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + H2O + O2 => H(+) + H2O2 + oxalate
REACT:R-BTA-3204311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOX1 oxidises PXL to PDXate (Bos taurus)
RHEA:41440	skos:prefLabel	"2-aminoethylphosphonate dioxygenase"
RHEA:41440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-aminoethylphosphonate dioxygenase"
RHEA:41440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate
REACT:R-BTA-917700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MVB Vesicle Formation (Bos taurus)
REACT:R-DRE-446634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IRAK4 is activated by autophosphorylation (Danio rerio)
REACT:R-HSA-2768999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 PEST domain mutants bind JAG1 (Homo sapiens)
REACT:R-MMU-5638009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)
RHEA:69537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-tagatopyranose 1-phosphate + ATP => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)
REACT:R-PFA-5694522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inner coat assembly and cargo binding (Plasmodium falciparum)
REACT:R-MMU-158750	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Mus musculus)
REACT:R-DRE-444606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T1R2/T1R3 dimer is a sweet taste receptor (Danio rerio)
RHEA:68394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + H(+) + H2O2 => H2O + peracetic acid
RHEA:43095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(2479) in 23S rRNA <=> 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
REACT:R-MMU-5653968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Mus musculus)
REACT:R-SSC-216756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)
REACT:R-XTR-176702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of Processive Complex and Completed Telomere End (Xenopus tropicalis)
RHEA:36879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O
RHEA:36918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA
RHEA:14385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl diphosphate + H2O = a dolichyl phosphate + H(+) + phosphate
RHEA:14385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichyldiphosphatase"
RHEA:14385	skos:prefLabel	"dolichyldiphosphatase"
REACT:R-XTR-6787642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Xenopus tropicalis)
REACT:R-SPO-69199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Schizosaccharomyces pombe)
GO:0072496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pup transferase activity
GO:0072496	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Pup conjugating enzyme activity
RHEA:21703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
RHEA:49027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tryptophan + O2 <=> 2-iminio-3-(indol-3-yl)propanoate + H2O2
REACT:R-BTA-8871366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Bos taurus)
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl-coenzyme A synthase activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoacetyl coenzyme A transacetase activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl-CoA synthase activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-hydroxy-beta-methylglutaryl-CoA synthase activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	HMG-CoA synthase activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl coenzyme A synthase activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme A synthase activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	hydroxymethylglutaryl coenzyme A-condensing enzyme
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxy-3-methylglutaryl CoA synthetase activity
GO:0004421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethylglutaryl-CoA synthase activity
RHEA:31557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-aminobutanoyl-CoA + acetoacetate => (5S)-5-amino-3-oxohexanoate + acetyl-CoA
REACT:R-CFA-981832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMUR2 binds neuromedin-S (Canis familiaris)
REACT:R-HSA-9759154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM21 ubiquitinates SQSTM1 (Homo sapiens)
REACT:R-MMU-211219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of caspase-3 to the nucleus (Mus musculus)
REACT:R-CFA-266050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4 is converted to LTC4 by LTC4S (Canis familiaris)
RHEA:33402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) <=> L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)
RHEA:14707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA-disulfide + H(+) + NADPH => 2 CoA + NADP(+)
RHEA:26239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeraniol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O
REACT:R-HSA-211919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP4F8 19-hydroxylates PGH2 (Homo sapiens)
REACT:R-XTR-983157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)
REACT:R-BTA-870269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gastrin binds to CCK-B receptor (Bos taurus)
REACT:R-HSA-426043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)
RHEA:63819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine <=> AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)
RHEA:14241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-4-hydroxybenzaldehyde + acetyl-CoA = 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)
REACT:R-MMU-211186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DFF45 (224) by caspase-3 (Mus musculus)
REACT:R-MMU-5218847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 binds NCK (Mus musculus)
REACT:R-MMU-173709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C7 binds C5b:C6 (Mus musculus)
GO:0004607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphatidylcholine:sterol O-acyltransferase activity
GO:0004607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LCAT activity
GO:0004607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lecithin--cholesterol acyltransferase activity
GO:0004607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylcholine-sterol O-acyltransferase activity
GO:0004607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phospholipid--cholesterol acyltransferase activity
GO:0004607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	LCAT (lecithin-cholesterol acyltransferase)
GO:0004607	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	lecithin:cholesterol acyltransferase activity
REACT:R-RNO-177934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGFR autophosphorylation (Rattus norvegicus)
RHEA:23946	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP => (E)-coniferol + UDP-alpha-D-glucose
RHEA:23855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	catechol + O2 <=> cis,cis-muconate + 2 H(+)
RHEA:48801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)
REACT:R-GGA-9033533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)
GO:0140660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytoskeletal motor activator activity
GO:0140660	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	motor activity activator activity
RHEA:24919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-homoserine = 2-aminobut-2-enoate + H2O
RHEA:51589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isopyridoxal + NAD(+) => 5-pyridoxolactone + H(+) + NADH
REACT:R-CEL-5678490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG16L1 complex transfers LC3 from ATG3 to PE (Caenorhabditis elegans)
RHEA:13616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-fructose 6-phosphate + diphosphate <=> beta-D-fructose 1,6-bisphosphate + H(+) + phosphate
RHEA:62016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
RHEA:62016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"EGF-domain serine xylosyltransferase"
RHEA:62016	skos:prefLabel	"EGF-domain serine xylosyltransferase"
GO:0034817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity
RHEA:20231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2,3-dihydroxybenzoyl-5'-AMP + diphosphate => 2,3-dihydroxybenzoate + ATP + H(+)
REACT:R-BTA-514604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Bos taurus)
REACT:R-CFA-975389	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Canis familiaris)
GO:0080082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	esculin beta-glucosidase activity
RHEA:11218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyribonucleoside 5'-diphosphate + ADP => a 2'-deoxyribonucleoside 5'-phosphate + ATP
RHEA:65174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z,5E)-dodecadienoate + CoA + H(+) => (3Z,5E)-dodecadienoyl-CoA + H2O
RHEA:67821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:72387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 hydrogencarbonate(out) + sulfate(in) = 2 hydrogencarbonate(in) + sulfate(out)
REACT:R-BTA-73805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)
REACT:R-MMU-1678694	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Mus musculus)
REACT:R-MMU-8848818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates CBL (Mus musculus)
EC:3.2.1.141	skos:altLabel	"maltooligosyl trehalose trehalohydrolase"
EC:3.2.1.141	skos:altLabel	"malto-oligosyltrehalose trehalohydrolase"
EC:3.2.1.141	skos:prefLabel	"4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase"
EC:3.2.1.141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase"
RHEA:23432	skos:altLabel	"(-)-limonene monooxygenase"
RHEA:23432	skos:altLabel	"(-)-limonene hydroxylase"
RHEA:23432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-limonene 7-monooxygenase"
RHEA:23432	skos:altLabel	"(-)-limonene 7-monooxygenase"
RHEA:23432	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:23432	skos:prefLabel	"(S)-limonene 7-monooxygenase"
RHEA:51978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-RNO-9020271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Rattus norvegicus)
REACT:R-RNO-193099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP17A1 cleaves 17aHPROG to ANDST (Rattus norvegicus)
RHEA:45196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase"
RHEA:45196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)
RHEA:45196	skos:prefLabel	"5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase"
RHEA:30553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-O-acetyl-beta-D-glucose + CoA => acetyl-CoA + beta-D-glucose
RHEA:29054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+)(in) + H2 + menaquinone-8 <=> 2 H(+)(out) + menaquinol-8
REACT:R-HSA-3234084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of TFAP2B with SUMO1 (Homo sapiens)
GO:0102779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cannabidiolate synthase activity
REACT:R-MMU-2465938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates atROL taken up by Muller cells (Mus musculus)
RHEA:33091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate
REACT:R-HSA-2559439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD14:LPS binds CR3 (Homo sapiens)
REACT:R-RNO-8850794	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK5 (Rattus norvegicus)
REACT:R-CFA-5682802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGI3 binds ADAM22,23,synatxin1 (Canis familiaris)
REACT:R-HSA-8849900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALMs1-3 bind each other in cis interactions (Homo sapiens)
RHEA:38019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
RHEA:19293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acylglycerol kinase"
RHEA:19293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate
RHEA:19293	skos:altLabel	"monoacylglycerol kinase"
RHEA:19293	skos:prefLabel	"acylglycerol kinase"
REACT:R-BTA-2213205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Type XII and XIV collagens associate with type I and type II fibrils. (Bos taurus)
REACT:R-XTR-8939801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26S proteasome degrades PolyUb-RUNX2 (Xenopus tropicalis)
RHEA:57876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(54) in tRNA = pseudouridine(54) in tRNA
RHEA:42350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP
RHEA:29242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + uracil(in) <=> H(+)(out) + uracil(out)
REACT:R-XTR-3322431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds TLE (Xenopus tropicalis)
REACT:R-CFA-110217	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 5-hydroxyluracil by UNG glycosylase (Canis familiaris)
REACT:R-BTA-3697894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN2 (Bos taurus)
REACT:R-CFA-8933452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAE dimer binds phosphorylated DENND1 proteins (Canis familiaris)
REACT:R-HSA-1855195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen (Homo sapiens)
REACT:R-DRE-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Danio rerio)
RHEA:69698	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + menadione + NADH <=> menadiol + NAD(+)
RHEA:49618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-2-methylpropanoate + 2 H(+) + NADH => 2-hydroxy-2-methylpropanal + H2O + NAD(+)
RHEA:36852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA
REACT:R-HSA-9714361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOC activates endoplasmic reticulum effectors (Homo sapiens)
GO:0031697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1 adrenergic receptor binding
GO:0031697	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta-1 adrenergic receptor ligand
REACT:R-HSA-990489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-13 is a dimer (Homo sapiens)
REACT:R-MMU-110376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Mus musculus)
REACT:R-HSA-4608854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1/2 are recruited to the DVL2:PARD6A complex (Homo sapiens)
REACT:R-HSA-6784676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)
RHEA:67903	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutarate + succinyl-CoA <=> glutaryl-CoA + succinate
RHEA:50535	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]
RHEA:45157	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxopropanoyl-CoA + H2O => 3-oxopropanoate + CoA + H(+)
RHEA:67230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA
RHEA:70018	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + teasterone <=> 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-CEL-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Caenorhabditis elegans)
REACT:R-XTR-6811417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Xenopus tropicalis)
REACT:R-DRE-939265	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Rap1 by membrane-associated GEFs (Danio rerio)
RHEA:64316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dihydrogeodin + 2 H(+) + O2 = 2 (+)-geodin + 2 H2O
RHEA:38392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)
RHEA:36215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
REACT:R-BTA-5694433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 binds PREB (Bos taurus)
RHEA:64744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + S-3-(hexan-1-ol)-L-cysteine = 3-sulfanyl-1-hexanol + NH4(+) + pyruvate
RHEA:32536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O => 4-hydroxy-2-oxohexanoate
RHEA:13517	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + dTMP = ADP + dTDP
RHEA:46414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
GO:0043993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K18 acetyltransferase activity
GO:0043993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K18 acetyltransferase activity
GO:0043993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H3-K18 specific)
GO:0043993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H3-K18 specific)
GO:0043993	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H3-K18 specific)
REACT:R-DRE-2467775	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocleavage of ESPL1 (Separase) (Danio rerio)
REACT:R-MMU-3371435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Constitutive phosphorylation by GSK3 (Mus musculus)
REACT:R-RNO-1433395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerization of sSCF (Rattus norvegicus)
RHEA:72006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate(in) + urate(out) <=> (S)-lactate(out) + urate(in)
RHEA:65237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylbutanol + acetyl-CoA => 3-methylbutyl acetate + CoA
GO:0102232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acrolein reductase activity
REACT:R-BTA-8855237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Bos taurus)
RHEA:59723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltohexaono-1,5-lactone + H2O <=> D-maltohexaonate + H(+)
RHEA:57372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NADPH = (6S)-NADPHX
REACT:R-DRE-444126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Danio rerio)
REACT:R-DRE-197972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHF is reduced to tetrahydrofolate (THF) (Danio rerio)
REACT:R-HSA-2900748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NOTCH1 HD+PEST domain mutants bind DLL1 (Homo sapiens)
RHEA:45887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA
GO:0048020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta chemokine receptor binding
GO:0048020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	CCR chemokine receptor ligand
GO:0048020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCR chemokine receptor binding
GO:0048020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	beta chemokine receptor ligand
REACT:R-BTA-2468039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Bos taurus)
REACT:R-MMU-5618099	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Mus musculus)
RHEA:24413	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(hydroxymethyl)benzenesulfonate + NAD(+) => 4-formylbenzenesulfonate + H(+) + NADH
REACT:R-DRE-202706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha4beta1 binds JAM2:JAM3 (Danio rerio)
REACT:R-HSA-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
RHEA:35573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-HSA-1225957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
REACT:R-BTA-8848975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates KHDRBS1 (Bos taurus)
REACT:R-DME-2176452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of ubiquitinated SMAD2 (Drosophila melanogaster)
RHEA:20688	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	galactitol + NAD(+) <=> H(+) + keto-D-tagatose + NADH
REACT:R-XTR-2997616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Xenopus tropicalis)
REACT:R-DRE-5694441	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CSNK1D phosphorylates SEC23 (Danio rerio)
REACT:R-RNO-8858475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFSF9 binds TNFRSF9 (Rattus norvegicus)
RHEA:66538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	25-hydroxycholest-4,6-dien-3-one + AH2 => A + cholest-4,6-dien-3-one + H2O
REACT:R-SSC-158340	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Sus scrofa)
REACT:R-BTA-8941312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Bos taurus)
RHEA:22306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-dehydro-D-fructose + a ubiquinol => a ubiquinone + keto-D-fructose
REACT:R-XTR-2426569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of DAP12 and IREM2 (Xenopus tropicalis)
REACT:R-SCE-205039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Saccharomyces cerevisiae)
RHEA:10288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-rhamnono-1,4-lactone = H(+) + L-rhamnonate
RHEA:10288	skos:prefLabel	"L-rhamnono-1,4-lactonase"
RHEA:10288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-rhamnono-1,4-lactonase"
REACT:R-DRE-71286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)
REACT:R-RNO-203553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS binds NOSIP (Rattus norvegicus)
REACT:R-SSC-5218820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Src kinases phosphorylate VAV (Sus scrofa)
REACT:R-CFA-1482962	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Canis familiaris)
REACT:R-DRE-166387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The FA anion diffuses away laterally from UCP (Danio rerio)
REACT:R-DDI-5651789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to POLB ligates SSB (Dictyostelium discoideum)
REACT:R-BTA-8850040	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Bos taurus)
RHEA:35638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP
REACT:R-RNO-8941543	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Rattus norvegicus)
REACT:R-XTR-5654669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Xenopus tropicalis)
REACT:R-MMU-2161961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EET(1) is hydrolysed to DHET(1) by EPHX2 (Mus musculus)
GO:0044017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-acetyltransferase activity (H3-K27 specific)
GO:0044017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K27 acetyltransferase activity
GO:0044017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3-K27 acetyltransferase activity
GO:0044017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetyltransferase activity (H3-K27 specific)
GO:0044017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone acetylase activity (H3-K27 specific)
RHEA:43810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
REACT:R-SSC-163809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)
RHEA:50092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acyl-CoA + taurine = an N-fatty acyl-taurine + CoA + H(+)
RHEA:60764	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone = cinerin II + CoA
REACT:R-HSA-212007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP26A1,B1 4-hydroxylate atRA (Homo sapiens)
RHEA:35126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-alanyl-D-glutamate(out) <=> H(+)(in) + L-alanyl-D-glutamate(in)
RHEA:16936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-aminocyclopropane-1-carboxylate + H2O <=> 2-oxobutanoate + NH4(+)
REACT:R-RNO-373724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin binds NCK (Rattus norvegicus)
REACT:R-HSA-1855233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Homo sapiens)
REACT:R-DRE-9749792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1,CES2 hydrolyze ASA- to ST (Danio rerio)
REACT:R-HSA-6809561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3)P2 is dephosphorylated into I1P by MTMR7 (Homo sapiens)
REACT:R-RNO-8982025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (q) in G (q):RGS complex is inactivated (Rattus norvegicus)
REACT:R-HSA-9730528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SARS-CoV-2 3a binds to STING (Homo sapiens)
REACT:R-CEL-5696230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTO1 dimer reduces methylarsonate to methylarsonite (Caenorhabditis elegans)
REACT:R-XTR-4641134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds AXIN (Xenopus tropicalis)
REACT:R-SPO-5623667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 phosphorylates PKN1,2,3 (Schizosaccharomyces pombe)
REACT:R-XTR-9007882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1F10 is cleaved (Xenopus tropicalis)
REACT:R-RNO-68611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ORC(1-5) complex (Rattus norvegicus)
REACT:R-DME-2028284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Drosophila melanogaster)
RHEA:34332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + indole-3-pyruvate + NADPH + O2 => (indol-3-yl)acetate + CO2 + H2O + NADP(+)
RHEA:20343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose
REACT:R-BTA-191422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mevalonate-5-phosphate is further phosphorylated. (Bos taurus)
RHEA:43100	skos:prefLabel	"tRNA(Ser) (uridine(44)-2'-O)-methyltransferase"
RHEA:43100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA(Ser) (uridine(44)-2'-O)-methyltransferase"
RHEA:43100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine
RHEA:40854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAD + H(+) + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + FADH2
RHEA:47383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]
RHEA:58697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + rifampicin => H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide
REACT:R-HSA-8964317	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Homo sapiens)
REACT:R-HSA-5661256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1A1 reduces D-glucuronate to L-gulonate (Homo sapiens)
REACT:R-BTA-199203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PANK1/3/4 phosphorylate PanK (Bos taurus)
RHEA:19577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	luteolin + UDP-alpha-D-glucose = H(+) + luteolin 7-O-beta-D-glucoside + UDP
RHEA:19577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apigenin + UDP-alpha-D-glucose = apigenin 7-O-beta-D-glucoside + H(+) + UDP
RHEA:19577	skos:prefLabel	"flavone 7-O-beta-glucosyltransferase"
RHEA:19577	skos:altLabel	"UDP-glucose-luteolin beta-D-glucosyltransferase"
RHEA:19577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"flavone 7-O-beta-glucosyltransferase"
RHEA:19577	skos:altLabel	"UDP-glucose-apigenin beta-glucosyltransferase"
RHEA:10572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"vinylacetyl-CoA Delta-isomerase"
RHEA:10572	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	vinylacetyl-CoA = (2E)-butenoyl-CoA
RHEA:10572	skos:prefLabel	"vinylacetyl-CoA Delta-isomerase"
RHEA:10572	skos:altLabel	"vinylacetyl coenzyme A isomerase"
REACT:R-CFA-9708759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHODH:FMN binds DHODH inhibitors (Canis familiaris)
REACT:R-CFA-6806967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CARKD dehydrates S-NAD(P)HX to NADPH (Canis familiaris)
REACT:R-BTA-5689111	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PARK2 autoubiquitinates (Bos taurus)
RHEA:18633	skos:altLabel	"GD-CPSase"
RHEA:18633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carbamoyl-phosphate synthase (glutamine-hydrolyzing)"
RHEA:18633	skos:altLabel	"carbamoyl phosphate synthetase (glutamine)"
RHEA:18633	skos:altLabel	"carbamoyl phosphate synthetase"
RHEA:18633	skos:altLabel	"CPS"
RHEA:18633	skos:altLabel	"glutamine-dependent carbamoyl-phosphate synthase"
RHEA:18633	skos:prefLabel	"carbamoyl-phosphate synthase (glutamine-hydrolyzing)"
RHEA:18633	skos:altLabel	"carbamoyl-phosphate synthetase (glutamine-hydrolyzing)"
RHEA:18633	skos:altLabel	"glutamine-dependent carbamoyl phosphate synthetase"
RHEA:18633	skos:altLabel	"carbamoylphosphate synthetase II"
RHEA:18633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate
RHEA:33881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH => 2-deoxy-scyllo-inosamine + NADP(+)
REACT:R-DRE-1675961	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Danio rerio)
GO:0050522	skos:prefLabel	"With other, known acceptors"
GO:0050522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With other, known acceptors"
GO:0050522	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors
RHEA:39861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacyl-sn-glycerol + glycerol => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol
RHEA:22280	skos:prefLabel	"O-demethylpuromycin O-methyltransferase"
RHEA:22280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"O-demethylpuromycin O-methyltransferase"
RHEA:22280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O-demethylpuromycin + S-adenosyl-L-methionine = H(+) + puromycin + S-adenosyl-L-homocysteine
REACT:R-BTA-177935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
GO:0050323	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurine dehydrogenase activity
GO:0050323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurine:acceptor oxidoreductase (deaminating)
GO:0050323	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	taurine:(acceptor) oxidoreductase (deaminating)
GO:0015440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	peptide-transporting ATPase activity
GO:0015440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP-dependent peptide transmembrane transporter activity
GO:0015440	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATPase-coupled peptide transmembrane transporter activity
GO:0015440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC-type peptide transporter activity
GO:0015440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide ABC transporter
REACT:R-CEL-5624126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome bind ciliary cargo (Caenorhabditis elegans)
REACT:R-CFA-706479	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TAK1 is activated (Canis familiaris)
REACT:R-CFA-2247513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1:ligand is endocytosed (Canis familiaris)
RHEA:67164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bromide + FADH2 + melleolide F + O2 = 6'-bromomelleolide F + FAD + 2 H2O
REACT:R-RNO-5432814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPA/SFTPD binds TLR2:TLR1 (Rattus norvegicus)
REACT:R-SCE-9018768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOU auto-activates (Saccharomyces cerevisiae)
REACT:R-BTA-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Bos taurus)
REACT:R-RNO-2485148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Rattus norvegicus)
RHEA:62187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peregrinol diphosphate <=> diphosphate + labd-13(16),14-diene-9-ol
REACT:R-DME-432067	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-4 passively transports water out of cell (Drosophila melanogaster)
RHEA:54277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-aspartyl-[protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate
RHEA:69488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetradecan-1-ol = H2O2 + tetradecanal
GO:0086038	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
RHEA:14626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) => [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)
RHEA:18980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + sn-glycerol 3-phosphate <=> a quinol + dihydroxyacetone phosphate
REACT:R-RNO-5653754	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Rattus norvegicus)
REACT:R-DRE-190782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of connexon-containing transport vesicles from the Golgi (Danio rerio)
RHEA:13063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione S,S-dioxide + H(+) => O2 + S-sulfanylglutathione
REACT:R-RNO-688136	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFAIP3 (A20) deubiquitinates RIP2 (Rattus norvegicus)
GO:0035299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol-pentakisphosphate 2-kinase activity
GO:0035299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity
GO:0035299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ins(1,3,4,5,6)P5 2-kinase activity
GO:0035299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Gsl1p
GO:0035299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity
GO:0035299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IP5 2-kinase activity
GO:0035299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Ipk1p
GO:0035299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol pentakisphosphate 2-kinase activity
GO:0035299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol hexakisphosphate synthase
GO:0035299	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	inositol polyphosphate kinase activity
REACT:R-MMU-446648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Mus musculus)
RHEA:48149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GT1b (d18:1(4E)/18:0) + H2O => ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate
GO:0019199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	transmembrane receptor protein kinase activity
GO:0047395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity
GO:0047395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerophosphoinositol glycerophosphodiesterase activity
GO:0047395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sn-glycero(3)phosphoinositol glycerophosphohydrolase activity
GO:0047395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity
REACT:R-CFA-201475	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I-Smad competes with R-Smad1/5/8 for type I receptor (Canis familiaris)
RHEA:25160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde
REACT:R-CEL-70666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Caenorhabditis elegans)
RHEA:28204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate
RHEA:39777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:19408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + citrate <=> (3S)-citryl-CoA + acetate
GO:0043395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heparan sulfate proteoglycan binding
GO:0043395	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	heparin proteoglycan binding
RHEA:21697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
REACT:R-HSA-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Homo sapiens)
GO:0047719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole-oxygen 2,3-oxidoreductase (decyclizing)
GO:0047719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole:O2 oxidoreductase activity
GO:0047719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole:oxygen 2,3-oxidoreductase (decyclizing)
GO:0047719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	indole oxidase activity
GO:0047719	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	indole 2,3-dioxygenase activity
GO:0047719	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IDO
RHEA:16857	skos:altLabel	"N(4)-cytosine-specific DNA methylase"
RHEA:16857	skos:altLabel	"restriction-modification system"
RHEA:16857	skos:prefLabel	"site-specific DNA-methyltransferase (cytosine-N(4)-specific)"
RHEA:16857	skos:altLabel	"modification methylase"
RHEA:16857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
RHEA:16857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"site-specific DNA-methyltransferase (cytosine-N(4)-specific)"
REACT:R-XTR-426032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG is metabolized by DAGL to 2-AG (Xenopus tropicalis)
REACT:R-HSA-451561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEMO binds polyubiquitinated IRAK1 (Homo sapiens)
RHEA:65602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + jolkinol C + 2 NADH => 4,5,8-trihydroxycasbene + 2 NAD(+)
REACT:R-DRE-8987223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL10RB binds TYK2 (Danio rerio)
REACT:R-BTA-193653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGF homodimer binds to p75NTR (Bos taurus)
REACT:R-HSA-9712208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 dissociates yielding GNAL:GTP (G alpha-olf:GTP), odorant:OlfactoryReceptor, and GNB1:GNG13 (Homo sapiens)
REACT:R-RNO-6788912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)
REACT:R-XTR-1296045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Potassium transport channels (Xenopus tropicalis)
RHEA:33035	skos:prefLabel	"spheroidene monooxygenase"
RHEA:33035	skos:altLabel	"spirilloxanthin monooxygenase"
RHEA:33035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"spheroidene monooxygenase"
RHEA:33035	skos:altLabel	"acyclic carotenoid 2-ketolase"
RHEA:33035	skos:altLabel	"2-oxo-spirilloxanthin monooxygenase"
RHEA:33035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-5218811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK180:ELMO binds CRK (Xenopus tropicalis)
REACT:R-DRE-5213466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 is phosphorylated (Danio rerio)
REACT:R-CFA-9728150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 binds gliflozins (Canis familiaris)
RHEA:55868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-lactate + O2 = H2O2 + pyruvate
REACT:R-SSC-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Sus scrofa)
RHEA:57277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-deoxyguanosine in DNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA
GO:0098879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	structural constituent of postsynaptic specialization
RHEA:23648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH
REACT:R-SSC-1679589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Engulfed CpG DNA binds to endosomal full-length TLR9 (Sus scrofa)
RHEA:25877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate + O2 => H2O2 + iminosuccinate
REACT:R-GGA-2132085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of C3 by surface-bound C3 convertases (Gallus gallus)
RHEA:21655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-chlorobenzoate + H(+) + NADH + O2 <=> catechol + chloride + CO2 + NAD(+)
RHEA:67960	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-amino-L-phenylalanine + S-adenosyl-L-methionine = 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine
REACT:R-SSC-2197770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAB1 (FEEL-1) binds ligands (Sus scrofa)
REACT:R-CFA-9012315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Canis familiaris)
RHEA:40320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O2
REACT:R-CEL-6814094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1:GTP binds ARFIP2 (Caenorhabditis elegans)
REACT:R-SSC-5140741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT5A binds FZD and ROR receptors (Sus scrofa)
RHEA:72598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) <=> H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)
RHEA:34022	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)
RHEA:56101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) => [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate
REACT:R-MMU-216045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type I binds integrin alpha11beta1 (Mus musculus)
REACT:R-MMU-110221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of uracil by SMUG1 glycosylase (Mus musculus)
REACT:R-XTR-2176502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD4L ubiquitinates SMAD2/3 (Xenopus tropicalis)
REACT:R-HSA-8878054	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HIPK2 phosphorylates RUNX1 (Homo sapiens)
RHEA:63614	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prunetin-5-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate
GO:0102365	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taxusin 2-alpha-hydroxylase activity
RHEA:36260	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-(1-hydroxyalkyl)-sn-glycerol => an aldehyde + glycerol
REACT:R-CFA-8987220	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Canis familiaris)
REACT:R-CEL-434989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA7A binds to PLXNC1 (Caenorhabditis elegans)
RHEA:48181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]
RHEA:35351	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H(+) + NADPH
REACT:R-BTA-382096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NR-NCOR Corepressor Complex (Bos taurus)
REACT:R-RNO-5660980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S276-RELA binds RELB (Rattus norvegicus)
REACT:R-GGA-167415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein alpha subunit is inactivated (Gallus gallus)
REACT:R-MMU-873918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of JAK1 (Mus musculus)
RHEA:40298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + CoA + hexadecanedioate <=> AMP + diphosphate + hexadecanedioyl-CoA
REACT:R-SSC-9024881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Sus scrofa)
REACT:R-HSA-2065549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Homo sapiens)
REACT:R-HSA-392051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of Grb2 to pFAK:NCAM1 (Homo sapiens)
REACT:R-XTR-8981353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RASA1 stimulates RAS GTPase activity (Xenopus tropicalis)
RHEA:55639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate
RHEA:37658	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
GO:0008783	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	agmatinase activity
GO:0008783	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	agmatine amidinohydrolase
GO:0008783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	agmatine ureohydrolase activity
GO:0008783	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	SpeB
GO:0047373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity
GO:0047373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetoxybutynylbithiophene esterase activity
GO:0047373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoxybutynylbithiophene deacetylase activity
GO:0047373	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity
RHEA:43288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate
RHEA:59416	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + tryptamine = H2O2 + indole-3-acetaldehyde + NH4(+)
RHEA:42868	skos:altLabel	"long-chain polyamine synthase"
RHEA:42868	skos:prefLabel	"caldopentamine synthase"
RHEA:42868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"caldopentamine synthase"
RHEA:42868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	norspermine + S-adenosyl 3-(methylsulfanyl)propylamine = caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine
REACT:R-MMU-446877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 is K63 poly-ubiquitinated (Mus musculus)
RHEA:34972	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe(3+)(in) => Fe(3+)(out)
REACT:R-GGA-983162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Gallus gallus)
RHEA:69773	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a short-chain fatty acid + 2 H(+) + NADH => a short-chain fatty aldehyde + H2O + NAD(+)
REACT:R-BTA-202222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PKC theta (Bos taurus)
RHEA:46809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine => [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine
RHEA:40526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a quinone + succinate <=> a quinol + fumarate
REACT:R-SSC-873918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transphosphorylation of JAK1 (Sus scrofa)
REACT:R-GGA-3772435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Gallus gallus)
REACT:R-SPO-9690461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP1A binds tacrolimus (Schizosaccharomyces pombe)
REACT:R-DRE-432237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Danio rerio)
REACT:R-GGA-9018836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOQ translocates to the Golgi-associated vesicle membranes (Gallus gallus)
RHEA:66489	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	quillate + UDP-alpha-D-glucose => quillaic acid 28-beta-D-glucoside + UDP
RHEA:50640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(2-methylsulfanyl)ethylmalate = 3-(2-methylsulfanyl)ethylmalate
RHEA:47466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,5Z)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA
REACT:R-HSA-69116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Okazaki fragments (Homo sapiens)
REACT:R-DME-9008043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK8 phosphorylation (Drosophila melanogaster)
GO:0015132	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	prostaglandin/thromboxane transporter activity
GO:0015132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin transmembrane transporter activity
REACT:R-MMU-68919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)
REACT:R-HSA-216061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPP1 (osteopontin) binds integrin alpha8beta1 (Homo sapiens)
REACT:R-RNO-388863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Rattus norvegicus)
REACT:R-CFA-917805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYBRD1:Heme reduces Fe3+ to Fe2+ (Canis familiaris)
REACT:R-MMU-1250353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Mus musculus)
REACT:R-MMU-8874435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THEM86B hydrolyses PMCHO, PMETAM (Mus musculus)
GO:0000828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inositol hexakisphosphate kinase activity
REACT:R-DRE-200680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from cytosol to mitochondrial matrix (Danio rerio)
RHEA:27805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-decaprenyl diphosphate + 7 diphosphate
RHEA:47600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM4 (d18:1(4E)) + H(+)
RHEA:45933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA
RHEA:47278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-6814797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ENPP6 hydrolyzes lysophosphatidylcholine (Canis familiaris)
REACT:R-DDI-2990842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SENP1,2,5 proteolytically process SUMO2 (Dictyostelium discoideum)
REACT:R-SSC-9023633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Sus scrofa)
RHEA:28738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + spermidine(out) <=> H(+)(out) + spermidine(in)
RHEA:18963	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(D-psicosyl)-L-lysyl-[protein] => D-allose + L-lysyl-[protein]
RHEA:54989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 e(-) + 4 H(+)(in) + O2(in) => 2 H2O(in)
RHEA:11160	skos:altLabel	"diaminobutyrate--2-oxoglutarate aminotransferase"
RHEA:11160	skos:altLabel	"diaminibutyric acid aminotransferase"
RHEA:11160	skos:altLabel	"diaminobutyrate transaminase"
RHEA:11160	skos:altLabel	"DAB aminotransferase"
RHEA:11160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate
RHEA:11160	skos:altLabel	"2,4-diaminobutyrate 4-aminotransferase"
RHEA:11160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"diaminobutyrate--2-oxoglutarate transaminase"
RHEA:11160	skos:prefLabel	"diaminobutyrate--2-oxoglutarate transaminase"
RHEA:11160	skos:altLabel	"DABA aminotransferase"
REACT:R-SSC-9749197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC1 binds to H4K20me2 (Sus scrofa)
RHEA:28749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+)(out) => NH4(+)(in)
REACT:R-HSA-5655284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4 mutants phosphorylate FRS2 (Homo sapiens)
REACT:R-BTA-159574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Bos taurus)
REACT:R-GGA-5674366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL17RD binds p-2S MAP2Ks and MAPKs (Gallus gallus)
RHEA:58422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methyl-2-butenal + H(+) + NADPH => NADP(+) + prenol
EC:2.3.1.284	skos:prefLabel	"3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase"
EC:2.3.1.284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase"
RHEA:63267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine
REACT:R-RNO-6781905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZRANB1 binds APC (Rattus norvegicus)
REACT:R-CFA-195280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Canis familiaris)
REACT:R-SCE-72670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of eIF2:GDP:eIF2B intermediate (Saccharomyces cerevisiae)
RHEA:55709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) => [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide
RHEA:26410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylmuramic acid 6-phosphate etherase"
RHEA:26410	skos:prefLabel	"N-acetylmuramic acid 6-phosphate etherase"
RHEA:26410	skos:altLabel	"MurNAc-6-P etherase"
RHEA:26410	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate
RHEA:16198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH
RHEA:67037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 => (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate
RHEA:15642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + oxaloacetate => CO2 + pyruvate
REACT:R-BTA-8956140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8 and UBD bind NUB1 and the 26S proteasome (Bos taurus)
REACT:R-XTR-374680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 trans-homophilic interaction (Xenopus tropicalis)
REACT:R-DDI-1855171	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)
REACT:R-CFA-141439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of activated MAD2 from kinetochores (Canis familiaris)
RHEA:31856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => achilleol B
RHEA:64875	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 1-phosphate <=> dihydroxyacetone phosphate + glycolaldehyde
RHEA:28978	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + L-asparagine(in) <=> H(+)(in) + L-asparagine(out)
RHEA:32507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate + H(+)
RHEA:41055	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA
REACT:R-MMU-5685607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sialic acid binds SIGLEC (Mus musculus)
REACT:R-CFA-5623527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Canis familiaris)
RHEA:68782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-humulene + diphosphate => (2Z,6Z)-farnesyl diphosphate
RHEA:20800	skos:altLabel	"glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase"
RHEA:20800	skos:altLabel	"chondroitin synthase"
RHEA:20800	skos:altLabel	"uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II"
RHEA:20800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RHEA:20800	skos:altLabel	"N-acetylgalactosaminyltransferase II"
RHEA:20800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RHEA:20800	skos:altLabel	"UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase"
RHEA:20800	skos:prefLabel	"glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase"
RHEA:20800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase"
RHEA:61339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + protoporphyrin IX(in) <=> ADP + H(+) + phosphate + protoporphyrin IX(out)
REACT:R-CFA-375417	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC36A1-mediated uptake of glycine, proline, and alanine (Canis familiaris)
GO:0019116	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxy-nicotine oxidase activity
RHEA:63071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 2 CO2 + 3 CoA + triacetate lactone
REACT:R-HSA-9636404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LAM translocates from the cell wall to the plasma membrane (Homo sapiens)
RHEA:63811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + citrate + spermidine <=> AMP + diphosphate + H(+) + N(8)-citryl-spermidine
REACT:R-MMU-442661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Mus musculus)
REACT:R-HSA-9756671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EOMES and TBXT bind the NANOG gene (Homo sapiens)
REACT:R-MMU-179467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Mus musculus)
RHEA:17452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + flaviolin <=> 3-linalylflaviolin + diphosphate
REACT:R-BTA-110244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Excision of FapyG by OGG1 glycosylase (Bos taurus)
REACT:R-HSA-1912388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 displaces co-repressor complex from RBPJ (CSL) (Homo sapiens)
REACT:R-HSA-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Homo sapiens)
RHEA:46228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[peptidyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]
RHEA:63074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 CO2 + 4 CoA + orcinol => acetyl-CoA + 3 H(+) + 3 malonyl-CoA
EC:3.4.21.55	skos:altLabel	"gabonase"
EC:3.4.21.55	skos:altLabel	"Bitis gabonica serine proteinase"
EC:3.4.21.55	skos:prefLabel	"venombin AB"
EC:3.4.21.55	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"venombin AB"
REACT:R-BTA-5607744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MALT1 binds BCL10 (Bos taurus)
RHEA:14722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-alpha-D-xylose + zeatin => H(+) + O-beta-D-xylosylzeatin + UDP
REACT:R-SSC-1358795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deubiquitination of RNF41 by P-USP8 (Sus scrofa)
RHEA:34247	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-deoxymethyl-sphinganine + NADP(+) = 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH
RHEA:15987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NADH => formate + NAD(+)
RHEA:45327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine
RHEA:58060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-sulfinoacetaldehyde + H2O = acetaldehyde + H(+) + sulfite
REACT:R-XTR-9708533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BACH1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)
REACT:R-GGA-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Gallus gallus)
GO:0072346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cADPR-sensitive calcium-release channel activity
RHEA:12045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a triacylglycerol + H2O => a diacylglycerol + a fatty acid + H(+)
REACT:R-CEL-5672824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated AKT1S1:mTORC1 binds YWHAB (Caenorhabditis elegans)
RHEA:68073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH => L-thiazolidine-2-carboxylate + NADP(+)
REACT:R-CFA-5696021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPGK:Mg2+ phosphorylates Glc to G6P (Canis familiaris)
REACT:R-HSA-2172172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 (Homo sapiens)
REACT:R-DDI-211881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Coumarin is 7-hydroxylated by CYP2A13 (Dictyostelium discoideum)
GO:0015378	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sodium:chloride symporter activity
GO:0016532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	superoxide dismutase copper chaperone activity
REACT:R-GGA-4084994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEU3 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)
RHEA:60566	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxy-D-glucose 6-phosphate + ADP + H(+) => 2-deoxy-D-glucose + ATP
RHEA:62552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosylceramide + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP
RHEA:44812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-11 + CO2 + diphosphate
REACT:R-BTA-8850992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proteasome degrades polyubiquitinated PTEN (Bos taurus)
RHEA:64765	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol
RHEA:35313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoheptadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisoheptadecanoyl-CoA + NADP(+)
GO:0140942	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3K9 dimethylation
GO:0140942	skos:prefLabel	"[histone H3]-lysine(9) N-dimethyltransferase"
GO:0140942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 mono/dimethylase activity
GO:0140942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone lysine N-dimethyltransferase activity (H3-K9 specific)
GO:0140942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 dimethylase activity
GO:0140942	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	histone H3-K9 dimethylation
GO:0140942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	histone H3K9 dimethyltransferase activity
GO:0140942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"[histone H3]-lysine(9) N-dimethyltransferase"
GO:0140942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine
RHEA:56166	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine
REACT:R-HSA-2046285	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The keratan chain can be capped by N-acetylneuraminic acid (Homo sapiens)
REACT:R-BTA-8878787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALPI dimer hydrolyses phosphate monoesters (Bos taurus)
RHEA:61257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-cysteine + O2 => 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)
RHEA:70397	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine => 3-oxosphinganine + docosanoyl-CoA
RHEA:38646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)
REACT:R-XTR-2161620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGH2 is isomerised to PGD2 by PTGDS (Xenopus tropicalis)
REACT:R-BTA-2574845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AJUBA binds centrosome-associated AURKA (Bos taurus)
RHEA:11659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[peptidyl-carrier protein] + L-proline <=> AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]
RHEA:50102	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-dodecanoyl-taurine => dodecanoyl-CoA + taurine
REACT:R-MMU-202129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)
RHEA:41450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(4S)-4-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2
RHEA:52283	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate
REACT:R-XTR-8848087	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAP2 recruits STAT3 to PTK6 (Xenopus tropicalis)
RHEA:26006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate = beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP
REACT:R-HSA-109864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Homo sapiens)
REACT:R-SSC-6805730	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SETD9 methylates TP53 (Sus scrofa)
RHEA:38812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
REACT:R-DDI-1638053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HEXA cleaves the terminal GalNAc from keratan sulfate (Dictyostelium discoideum)
REACT:R-MMU-2066779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Mus musculus)
REACT:R-DME-373746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SEMA4D interacts with CD45 (Drosophila melanogaster)
GO:0043138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 3'-5' DNA helicase activity
GO:0043138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-5' DNA helicase activity
GO:0043138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' to 5' DNA helicase activity
GO:0043138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP-dependent 3' to 5' DNA helicase activity
RHEA:66772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + uroporphyrin I(in) = ADP + H(+) + phosphate + uroporphyrin I(out)
REACT:R-HSA-2262743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain) (Homo sapiens)
REACT:R-SCE-1483182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to PA and choline by PLD1/2 (Saccharomyces cerevisiae)
RHEA:70168	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)
RHEA:28269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (S)-beta-bisabolene + diphosphate
RHEA:41740	skos:prefLabel	"tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase"
RHEA:41740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase"
RHEA:41740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine
RHEA:40724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9E)-octadecenoyl-CoA + H2O => (9E)-octadecenoate + CoA + H(+)
RHEA:48379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)
REACT:R-CEL-3301943	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTK1 dimer transfers GS from GSH to CDNB (Caenorhabditis elegans)
REACT:R-MMU-8943003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHPRH polyubiquitinates monoubiquitinated PCNA (Mus musculus)
RHEA:66970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose
REACT:R-HSA-2889036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translation of OCT4 mRNA (Homo sapiens)
REACT:R-BTA-8852133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 conjugates ubiquitin to UBA1 in the cytosol (Bos taurus)
RHEA:55273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11-cis-retinol + tetradecanoyl-CoA => 11-cis-retinyl tetradecanoate + CoA
RHEA:30461	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol
RHEA:18619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + CO2 + phosphoenolpyruvate => ATP + oxaloacetate
RHEA:15716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactoside + acetyl-CoA <=> a 6-acetyl-beta-D-galactoside + CoA
RHEA:49904	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2
REACT:R-HSA-507873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport urea out of cells (Homo sapiens)
REACT:R-DDI-76354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vinyl chloride is oxidized to 2-Chloroethylene oxide (Dictyostelium discoideum)
GO:0017017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0017017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dual-specificity MAP kinase phosphatase activity
REACT:R-HSA-9634219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUP93 recruits the Nup62 complex (Homo sapiens)
RHEA:64585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyethane-1-sulfonate(out) + Na(+)(out) => 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)
GO:0018604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate 3,4-dioxygenase (deaminating) activity
RHEA:13661	skos:prefLabel	"formimidoylaspartate deiminase"
RHEA:13661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formimidoyl-L-aspartate = N-formyl-L-aspartate + NH4(+)
RHEA:13661	skos:altLabel	"formiminoaspartate deiminase"
RHEA:13661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formimidoylaspartate deiminase"
RHEA:63561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	angiotensin I + H2O => angiotensin II + L-histidyl-L-leucine
REACT:R-DDI-444433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cho transports from the extracellular space to the cytosol (Dictyostelium discoideum)
RHEA:44052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA
REACT:R-MMU-8849435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN1 dephosphorylates PTK6 (Mus musculus)
REACT:R-HSA-6809006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
REACT:R-CFA-5654729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Canis familiaris)
REACT:R-RNO-6802973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK3 phosphorylates CDC25C (Rattus norvegicus)
RHEA:27435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutathione amide disulfide + H(+) + NADH => 2 glutathione amide + NAD(+)
RHEA:71979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene A
REACT:R-DRE-428625	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Vesicular inhibitory amino acid transport (Danio rerio)
REACT:R-HSA-388814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Grb2 binds CD28 (Homo sapiens)
REACT:R-HSA-194153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCC3 transports bile salts from cytosol to extracellular region (Homo sapiens)
RHEA:54197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
RHEA:12401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-ribonucleotide + H2O => NH4(+) + nicotinate beta-D-ribonucleotide
REACT:R-BTA-211206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of DFF to the nucleus (Bos taurus)
RHEA:72299	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) = 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)
GO:1901515	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity
REACT:R-CFA-197268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)
RHEA:15049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"GDP-glucosidase"
RHEA:15049	skos:prefLabel	"GDP-glucosidase"
RHEA:15049	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-alpha-D-glucose + H2O = D-glucose + GDP + H(+)
RHEA:53115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH
GO:0034909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxypseudooxynicotine dehydrogenase activity
RHEA:44654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine
GO:0016649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
GO:0016649	skos:prefLabel	"With a quinone or similar compound as acceptor"
GO:0016649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"With a quinone or similar compound as acceptor"
REACT:R-DRE-8985591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLIT2-bound ROBO1 binds MYO9B (Danio rerio)
REACT:R-DRE-6805650	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTA2-NuRD complex deacetylates TP53 (Danio rerio)
RHEA:59232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + hydropyrenol
RHEA:59232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydropyrenol synthase"
RHEA:59232	skos:prefLabel	"hydropyrenol synthase"
REACT:R-SSC-727759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Sus scrofa)
REACT:R-HSA-9661799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)
REACT:R-BTA-194308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Bos taurus)
RHEA:62870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+) => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2
RHEA:48227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + L-fucose
REACT:R-MMU-877198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates membrane pores that include pannexin-1 (Mus musculus)
REACT:R-SSC-9679787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)
GO:0008257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein histidine tele-kinase activity
GO:0008257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein-histidine tele-kinase"
GO:0008257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-histidine tele-kinase activity
GO:0008257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein-L-histidine N-tele-phosphotransferase activity
GO:0008257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-histidyl-[protein] = ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]
GO:0008257	skos:altLabel	"protein histidine kinase"
GO:0008257	skos:altLabel	"histidine kinase"
GO:0008257	skos:prefLabel	"protein-histidine tele-kinase"
GO:0008257	skos:altLabel	"protein kinase (histidine)"
GO:0008257	skos:altLabel	"HK3"
GO:0008257	skos:altLabel	"histidine protein kinase"
GO:0008257	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein-L-histidine Ntau-phosphotransferase activity
REACT:R-DRE-380574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dopamine synaptic vesicle docking and priming (Danio rerio)
REACT:R-SSC-8944242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVII (Sus scrofa)
RHEA:60886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O
RHEA:53988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate
REACT:R-RNO-1861595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Extension of pseudopodia by myosin-X in a PI3K dependent manner (Rattus norvegicus)
REACT:R-SCE-1483165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PA is converted to CDP-DAG by CDS2 (Saccharomyces cerevisiae)
REACT:R-MMU-6785607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FANCM binds FAAP24 (Mus musculus)
REACT:R-GGA-5654608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2:p-FRS bind to PPTN11 (Gallus gallus)
REACT:R-XTR-8951751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Xenopus tropicalis)
RHEA:66738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + beta-citrylglutamate(out) + H(+) + phosphate => ATP + beta-citrylglutamate(in) + H2O
RHEA:39382	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)
REACT:R-SSC-9704248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM4 binds CHRM4 antagonists (Sus scrofa)
REACT:R-HSA-1592240	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of NRF2 (Homo sapiens)
REACT:R-CFA-9620532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT1,SIRT3 deacetylate FOXO3 (Canis familiaris)
RHEA:49817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Fe(III)-[cytochrome c] + H2O + hydrazine => 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide
RHEA:43073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0052876	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	amine dehydrogenase
GO:0052876	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	primary-amine dehydrogenase
GO:0052876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylamine dehydrogenase (amicyanin) activity
GO:0052876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylamine dehydrogenase activity
GO:0052876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylamine:amicyanin oxidoreductase (deaminating) activity
GO:0052876	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	MADH activity
RHEA:24014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine => gamma-tocopherol + S-adenosyl-L-methionine
REACT:R-MMU-75851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)
RHEA:18440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-CDP-2-C-methyl-D-erythritol + ATP <=> 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)
REACT:R-BTA-200720	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A32 transports THF from mitochondrial matrix to cytosol (Bos taurus)
REACT:R-DME-110453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PIP2 to PIP3 by Dp110 (Drosophila melanogaster)
REACT:R-GGA-4086392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDE6 hydrolyses cGMP to GMP (Gallus gallus)
RHEA:47160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-methylzymosterol-4alpha-carboxylate + NAD(+) = 3-dehydro-4-methylzymosterol + CO2 + NADH
REACT:R-CFA-196955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
RHEA:10629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphate + tRNA(n+1) => a ribonucleoside 5'-diphosphate + tRNA(n)
REACT:R-CEL-975633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atROL binds to RBP2 (Caenorhabditis elegans)
RHEA:68810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose + D-fructose => 6-O-alpha-D-glucopyranosyl-D-fructose + H2O
REACT:R-DME-9639286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)
REACT:R-CFA-1676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)
REACT:R-DDI-174139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phospho-Cdh1 from the APC/C complex (Dictyostelium discoideum)
REACT:R-CEL-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Caenorhabditis elegans)
REACT:R-XTR-9733969	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bile salts dissociate from FABP6 (Xenopus tropicalis)
REACT:R-MMU-2453876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTR:RBP:atROL binds to STRA6 receptor (Mus musculus)
RHEA:62911	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nor-toralactone + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toralactone
REACT:R-HSA-5685290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SFTPD gene produces SFTPD protein (Homo sapiens)
REACT:R-MMU-1482626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPI is acylated to PI by MBOAT7 (Mus musculus)
REACT:R-CFA-2065357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)
RHEA:35708	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-versicolorone + H(+) + NADPH + O2 => (3S)-versiconol acetate + H2O + NADP(+)
REACT:R-SSC-190065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TrkA receptor internalizes to endosomes (Sus scrofa)
REACT:R-MMU-9753280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSTs transfer GSH to NAPQI to form APAP-SG (Mus musculus)
RHEA:18269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH
RHEA:18269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(S)-3-hydroxyacid-ester dehydrogenase"
RHEA:18269	skos:prefLabel	"(S)-3-hydroxyacid-ester dehydrogenase"
RHEA:18269	skos:altLabel	"3-oxo ester (S)-reductase"
REACT:R-XTR-5693373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Xenopus tropicalis)
RHEA:63226	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2
REACT:R-RNO-5661117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Rattus norvegicus)
REACT:R-DRE-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Danio rerio)
RHEA:42664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-L-arabinopyanose + NADP(+) = H(+) + L-arabinono-1,4-lactone + NADPH
RHEA:24595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP + H(+) + phosphoethanolamine <=> CDP-ethanolamine + diphosphate
RHEA:14636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + Na(+)(in) <=> ADP + H(+) + Na(+)(out) + phosphate
RHEA:41151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)
REACT:R-MMU-198266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
REACT:R-DRE-390393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Peroxisomal uptake of very long-chain fatty acyl CoA (Danio rerio)
REACT:R-RNO-5660665	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 binds MALT (Rattus norvegicus)
REACT:R-XTR-9728748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Bitter compound binds bitter taste receptor (TAS2R) (Xenopus tropicalis)
REACT:R-XTR-188467	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Xenopus tropicalis)
RHEA:68034	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+) => (S)-cystathionine ketimine + 2 H(+) + NADH
RHEA:14339	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate => 3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate
RHEA:12706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-L-isoaspartate + S-adenosyl-L-methionine => [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine
EC:3.4.24.63	skos:prefLabel	"meprin B"
EC:3.4.24.63	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"meprin B"
REACT:R-MMU-432074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-7 passively transports glycerol out of cell (Mus musculus)
RHEA:22722	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N(pros)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]
REACT:R-DRE-8983841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 associates with IL6ST:IL6ST (Danio rerio)
REACT:R-DRE-8956200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Danio rerio)
RHEA:47802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an aromatic oxo-acid + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid
RHEA:57471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-ferulate + UDP-alpha-D-glucose <=> 1-O-[(E)-feruloyl]-beta-D-glucose + UDP
RHEA:14205	skos:prefLabel	"carnosine N-methyltransferase"
RHEA:14205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"carnosine N-methyltransferase"
RHEA:14205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carnosine + S-adenosyl-L-methionine = anserine + H(+) + S-adenosyl-L-homocysteine
RHEA:24568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-phospho-beta-D-galactoside + H2O = an alcohol + D-galactose 6-phosphate
REACT:R-DRE-211988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Danio rerio)
RHEA:44369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cr(6+) + 2 NADPH + O2 => Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide
REACT:R-SSC-70420	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HK1,2,3,GCK phosphorylate Glc to form G6P (Sus scrofa)
REACT:R-XTR-917841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)
REACT:R-MMU-170026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protons are translocated from the intermembrane space to the matrix (Mus musculus)
RHEA:60146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[protein]
RHEA:43840	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:35189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-aminoacrylate + A + H(+) + H2O => (Z)-3-aminoperacrylic acid + AH2
RHEA:44957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-hexenoyl-CoA + H(+) + NADPH => hexanoyl-CoA + NADP(+)
REACT:R-HSA-3266557	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I cleaves iC3b (Homo sapiens)
REACT:R-RNO-190427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autocatalytic phosphorylation of FGFR1b (Rattus norvegicus)
REACT:R-SSC-9017488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOJ GAPs stimulate RHOJ GTPase activity (Sus scrofa)
RHEA:30138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanoyl-CoA + H2O <=> CoA + dodecanoate + H(+)
REACT:R-HSA-193401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
REACT:R-GGA-5665727	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMNL2 binds CDC42:GTP (Gallus gallus)
REACT:R-GGA-4570528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of XPC with SUMO1 (Gallus gallus)
REACT:R-BTA-8952408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitinated RUNX3 is degraded by the proteasome (Bos taurus)
REACT:R-SSC-5692261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALDH3A2-1 oxidises HD2NAL to PALM (Sus scrofa)
RHEA:13810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspulvinone E + 2 dimethylallyl diphosphate => aspulvinone H + 2 diphosphate
REACT:R-HSA-198733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERK5 is activated (Homo sapiens)
RHEA:46636	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5beta-dihydrotestosterone + NADP(+) = H(+) + NADPH + testosterone
REACT:R-GGA-5617037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Gallus gallus)
REACT:R-RNO-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Rattus norvegicus)
REACT:R-HSA-2160884	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Homo sapiens)
RHEA:56608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methylenetetrahydrosulfopterin + glycine + H2O = L-serine + tetrahydrosulfopterin
RHEA:47774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a guanosine in 21S rRNA + S-adenosyl-L-methionine
GO:0018818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AHy
GO:0018818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetaldehyde hydro-lyase activity
GO:0018818	skos:prefLabel	"acetylene hydratase"
GO:0018818	skos:altLabel	"AHy"
GO:0018818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetaldehyde = acetylene + H2O
GO:0018818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylene hydratase activity
GO:0018818	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylene hydratase"
GO:0018818	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AH
REACT:R-DME-2130706	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MHC class II antigen processing (Drosophila melanogaster)
REACT:R-CFA-5339528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TUSC3 transports Mg2+ from extracellular region to cytosol (Canis familiaris)
RHEA:54078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + stellata-2,6,19-triene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate
REACT:R-GGA-5667008	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA:GTP binds RHPN1 or RHPN2 (Gallus gallus)
REACT:R-MMU-2395992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-T,4S-IRF3 is dimerized (Mus musculus)
RHEA:25613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E,10E)-geranylgeranyl diphosphate = terpentedienyl diphosphate
RHEA:25613	skos:altLabel	"terpentedienol diphosphate synthase"
RHEA:25613	skos:prefLabel	"terpentedienyl-diphosphate synthase"
RHEA:25613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"terpentedienyl-diphosphate synthase"
RHEA:25613	skos:altLabel	"clerodadienyl diphosphate synthase"
GO:0030736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:phenol O-methyltransferase activity
GO:0030736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenol O-methyltransferase activity
GO:0030736	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PMT
RHEA:48796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:37294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanyl-L-leucine <=> L-alanine + L-leucine
REACT:R-CFA-5668520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	26Sproteasome degrades K48polyUb-NIK (Canis familiaris)
REACT:R-GGA-977371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates Factor H-boundC3b (Gallus gallus)
REACT:R-DME-5675198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MAPKs phosphorylate BRAF (Drosophila melanogaster)
REACT:R-HSA-9028728	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTRK2 phosphorylates FRS2 (Homo sapiens)
REACT:R-XTR-77263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Xenopus tropicalis)
REACT:R-GGA-9750666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds ST (Gallus gallus)
RHEA:37599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-CoA 15-desaturase"
RHEA:37599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O
RHEA:37599	skos:prefLabel	"acyl-CoA 15-desaturase"
REACT:R-DME-5696004	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACSF2 ligates CoA-SH to MCFA (Drosophila melanogaster)
RHEA:72713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4,21-dehydrogeissoschizine => cathenamine + H(+)
REACT:R-HSA-877198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2X7 mediates membrane pores that include pannexin-1 (Homo sapiens)
REACT:R-BTA-8853801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PSPN binds RET:GFRA4 (Bos taurus)
REACT:R-XTR-8963851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VD3 dissociates from GC (Xenopus tropicalis)
REACT:R-SSC-159796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-factor IX to factor IX (Sus scrofa)
REACT:R-XTR-3296233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	T2Rs bind bitter-tasting compounds (Xenopus tropicalis)
RHEA:52237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin b
RHEA:68036	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-cystathionine ketimine + 2 H(+) + NADPH = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)
REACT:R-HSA-450431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (TTP) recruits RNA degradation activities (Homo sapiens)
RHEA:41618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 5-phosphate + phosphate => D-ribose 2,5-bisphosphate + H2O
REACT:R-MMU-9756169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)
GO:0102256	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity
RHEA:49797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-glycine + H2O => a fatty acid + glycine
REACT:R-GGA-879377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Gallus gallus)
REACT:R-DRE-202604	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of a heteromeric BMP receptor complex (Danio rerio)
RHEA:32583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrocarvone + H(+) + NADPH + O2 = 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)
GO:0047374	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	esterase D activity
GO:0047374	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-methylumbelliferyl-acetate acylhydrolase activity
GO:0047374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylumbelliferyl-acetate deacetylase activity
RHEA:61263	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-glutamine + O2 <=> 2-oxoglutaramate + H2O2 + NH4(+)
REACT:R-XTR-419428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR2-5 bind S1P (Xenopus tropicalis)
RHEA:18061	skos:prefLabel	"formylmethanofuran--tetrahydromethanopterin N-formyltransferase"
RHEA:18061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"formylmethanofuran--tetrahydromethanopterin N-formyltransferase"
RHEA:18061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin
RHEA:47277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0005184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neurohormone
GO:0005184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuropeptide hormone activity
RHEA:69375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyhexanoate + O2 <=> 2-oxohexanoate + H2O2
RHEA:35083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetylchitobiose-6'-phosphate + H2O = acetate + N'-monoacetylchitobiose-6'-phosphate
RHEA:18803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(cis-prenyl)(n+1)-diphosphate + diphosphate => (cis-prenyl)n-diphosphate + isopentenyl diphosphate
GO:0046623	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphingolipid-translocating ATPase activity
GO:0046623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid floppase activity
GO:0046623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid floppase activity (cytosolic to exoplasmic leaftlet)
GO:0046623	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingolipid flippase activity
REACT:R-HSA-392831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) (Homo sapiens)
REACT:R-DRE-1482545	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)
RHEA:69350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate => S-1-propenyl-L-cysteine sulfoxide
RHEA:52524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60834	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate => a 5'-end triphospho-guanosine in mRNA + H2O
REACT:R-MMU-5693620	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-loop formation mediated by PALB2, BRCA2 and RAD51 (Mus musculus)
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	janus kinase 2 activity
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	non-membrane spanning protein tyrosine kinase activity
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP:protein-tyrosine O-phosphotransferase activity
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	janus kinase 3 activity
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	Bruton's tyrosine kinase activity
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	focal adhesion kinase activity
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	non-specific protein-tyrosine kinase activity
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	p60c-src protein tyrosine kinase activity
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cytoplasmic protein tyrosine kinase activity
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity
GO:0004715	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	janus kinase 1 activity
RHEA:69437	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-oxopregnenolone + H(+) + NADPH => 7beta-hydroxypregnenolone + NADP(+)
REACT:R-DME-71306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribulose 5-phosphate <=> ribose 5-phosphate (Drosophila melanogaster)
REACT:R-HSA-6787594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 (Homo sapiens)
RHEA:40328	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-MMU-450400	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Mus musculus)
RHEA:10796	skos:altLabel	"albendazole sulfoxidase"
RHEA:10796	skos:prefLabel	"albendazole monooxygenase"
RHEA:10796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"albendazole monooxygenase"
RHEA:10796	skos:altLabel	"albendazole monooxygenase (flavin-containing)"
RHEA:10796	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	albendazole + H(+) + NADPH + O2 = albendazole S-oxide + H2O + NADP(+)
RHEA:17955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => 3-hydroxyanthranilate + O2
REACT:R-DDI-508369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Dictyostelium discoideum)
REACT:R-SSC-8847995	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated ERBB2 binds PTK6 (BRK) (Sus scrofa)
RHEA:50369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylbutan-2-ol + H(+) + NADPH + O2 => 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)
RHEA:67480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + prekainate = CO2 + H2O + kainate + succinate
RHEA:37564	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-CEL-432707	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)
REACT:R-RNO-109449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Rattus norvegicus)
REACT:R-CFA-75887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Conversion of Glycerol to Glycerol-3-phosphate (Canis familiaris)
REACT:R-SSC-9632910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Sus scrofa)
REACT:R-SSC-936986	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TRAF6 synthesizes unanchored polyubiquitin chains (Sus scrofa)
REACT:R-SSC-9626880	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Sus scrofa)
RHEA:20128	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA:68870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + benzaldehyde + diphosphate + NADP(+) => ATP + benzoate + H(+) + NADPH
RHEA:60742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(-)-citronellate + 2 H(+) + NADPH => (S)-(-)-citronellal + H2O + NADP(+)
REACT:R-HSA-9018774	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB1 binds GTP (Homo sapiens)
GO:0140142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleocytoplasmic carrier activity
GO:0140142	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	pre-miRNA transporter activity
GO:0140142	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	miRNA transporter activity
GO:0140142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleocytoplasmic importin/exportin activity
REACT:R-DME-9012835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDIs block activation of RHOA (Drosophila melanogaster)
REACT:R-DRE-8874979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACBD3 binds GOLGB1 (Danio rerio)
RHEA:20558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + urea => CO2 + 2 NH4(+)
REACT:R-MMU-5668404	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNFA binds TNFR2 (Mus musculus)
RHEA:63016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)
REACT:R-CFA-879942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor is activated (Canis familiaris)
RHEA:20584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + NAD(+) + NH4(+) <=> 2 H(+) + hydroxylamine + NADH
RHEA:54618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxyheptadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + heptadecanoyl-CoA + O2
REACT:R-DRE-72673	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of 40S and 60S subunits from the 80S ribosome  (Danio rerio)
RHEA:72428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) + K(+)(in) => chloride(out) + K(+)(out)
REACT:R-CFA-1168643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)
REACT:R-MMU-1482856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Mus musculus)
REACT:R-MMU-5610733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Mus musculus)
RHEA:60051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)
RHEA:43403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP
RHEA:22194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
REACT:R-HSA-201445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Homo sapiens)
REACT:R-DDI-143468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MEOS oxidizes ethanol to acetaldehyde (Dictyostelium discoideum)
RHEA:37196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	octadecanoyl-CoA + sn-glycerol 3-phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + CoA
REACT:R-GGA-425994	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Na+/H+ exchanger transport (at cell membrane) (Gallus gallus)
EC:3.4.21.21	skos:prefLabel	"coagulation factor VIIa"
EC:3.4.21.21	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"coagulation factor VIIa"
RHEA:45280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate
REACT:R-XTR-2022061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dermatan sulfate can be further sulfated on position 2 of iduronate (Xenopus tropicalis)
RHEA:32060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O => (R)-glycerate + D-glucose
RHEA:35815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate
RHEA:64558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-epi-ilicicolin H => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one
GO:0033460	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamic acid tRNA
GO:0033460	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAG codon-amino acid adaptor activity
GO:0016401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	palmitoyl-CoA oxidase activity
RHEA:24252	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)
REACT:R-MMU-141046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Mus musculus)
REACT:R-MMU-202214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)
REACT:R-DRE-73571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Danio rerio)
REACT:R-CFA-3000327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLK1 phosphorylates BORA (Canis familiaris)
REACT:R-DME-3299569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Drosophila melanogaster)
RHEA:42137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine
REACT:R-RNO-205319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of APS and p-KIT (Rattus norvegicus)
REACT:R-SSC-9024326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Sus scrofa)
REACT:R-CFA-5624126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL6:GTP and the BBSome bind ciliary cargo (Canis familiaris)
GO:0102912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(-)-lactol dehydrogenase activity
REACT:R-HSA-77081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of the CE:GMP intermediate complex (Homo sapiens)
GO:0047385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain oxo-acid dehydrogenase phosphatase activity
GO:0047385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity
GO:0047385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity
GO:0047385	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity
GO:0047385	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	branched-chain alpha-keto acid dehydrogenase phosphatase
GO:0047385	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	branched-chain 2-keto acid dehydrogenase phosphatase activity
GO:0003990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl.beta-methylcholinesterase activity
GO:0003990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylcholine hydrolase activity
GO:0003990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AcCholE
GO:0003990	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholinesterase activity
GO:0003990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	choline esterase I activity
GO:0003990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylcholine acetylhydrolase activity
GO:0003990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetylthiocholinesterase activity
GO:0003990	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	true cholinesterase activity
REACT:R-CFA-508513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK2B binds JAK3 (Canis familiaris)
REACT:R-DME-6801762	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	REG3A oligomerize to form a pore complex (Drosophila melanogaster)
REACT:R-CEL-5694439	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	COPII coat binds TRAPPCII and RAB1:GDP (Caenorhabditis elegans)
REACT:R-XTR-9678854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S1PR1 binds S1PR1 agonists (Xenopus tropicalis)
REACT:R-XTR-174079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)
RHEA:65856	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + a 1-hydroxy-3-oxo steroid = a steroid 1,3-dione + AH2
REACT:R-DRE-110319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elongation by POLH (Danio rerio)
RHEA:34552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(II)yrinate c monoamide + H2O + L-glutamine => ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate
REACT:R-BTA-6782204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Bos taurus)
REACT:R-CFA-448955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of MEF2 proteins by p38 (Canis familiaris)
REACT:R-DRE-9027633	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Danio rerio)
RHEA:34293	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose
REACT:R-RNO-914005	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Rattus norvegicus)
RHEA:18887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-beta-L-fucose + NADP(+)
REACT:R-RNO-8870346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Rattus norvegicus)
RHEA:60424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + H2O = diphosphate + valerianol
RHEA:60424	skos:prefLabel	"valerianol synthase"
RHEA:60424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"valerianol synthase"
REACT:R-CFA-204873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and Shp2 (Canis familiaris)
REACT:R-XTR-9693214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOD binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)
REACT:R-MMU-389424	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The orphan QRFP receptor can bind neuropeptide QRFP (Mus musculus)
RHEA:43239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + phosphate
REACT:R-XTR-8866269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARRB bind GPCRs (Xenopus tropicalis)
REACT:R-CFA-6811418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Canis familiaris)
RHEA:27647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	inosine + phosphate => alpha-D-ribose 1-phosphate + hypoxanthine
REACT:R-BTA-4420107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds SHC-transforming protein 2 (Bos taurus)
REACT:R-RNO-1299507	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Methylthio-ribulose-P = Methylthio-ribose-P (Rattus norvegicus)
REACT:R-MMU-1112587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT1 and STAT3 dimers translocate to the nucleus (Mus musculus)
RHEA:48106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine
RHEA:36971	skos:prefLabel	"dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase"
RHEA:36971	skos:altLabel	"dTDP-4-keto-6-deoxyglucose 3-epimerase"
RHEA:36971	skos:altLabel	"dTDP-deoxyglucose 3-epimerase"
RHEA:36971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase"
RHEA:36971	skos:altLabel	"dTDP-4-keto-6-deoxy-D-glucose 3-epimerase"
RHEA:36971	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-allose
RHEA:65786	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
GO:1990599	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' overhang single-stranded DNA endodeoxyribonuclease activity
RHEA:37063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine
GO:0047561	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyanthranilate:oxygen oxidoreductase activity
GO:0047561	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3-hydroxyanthranilic acid oxidase activity
GO:0047561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate oxidase activity
RHEA:69042	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-nitrobutanedioate + H2O + NADP(+) => (2S)-2-nitrosobutanedioate + H(+) + NADPH + O2
REACT:R-CEL-629596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
REACT:R-CEL-8959462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SAMD8 transforms PE and CERA to CPE (Caenorhabditis elegans)
REACT:R-BTA-8944254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVI (Bos taurus)
REACT:R-CFA-8937369	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATAD2 binds ESR1 (Canis familiaris)
REACT:R-DME-445704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Calcium Binds Caldesmon (Drosophila melanogaster)
RHEA:14211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + H(+) + UTP
RHEA:27480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + neopinone + succinate
REACT:R-CFA-4084912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arresten binds integrin alpha1beta1 (Canis familiaris)
REACT:R-DRE-75090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of ADAR1 homodimer to dsRNA duplex (Danio rerio)
RHEA:42795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholesterol + hexadecanoyl-CoA <=> cholesteryl hexadecanoate + CoA
REACT:R-BTA-417829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2RY12 binds ADP (Bos taurus)
RHEA:19014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dTTP + H2O => dTDP + H(+) + phosphate
GO:0034886	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gamma-aminovinylacetate deaminase activity
REACT:R-SCE-6797100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CCNK binds CDK13 (Saccharomyces cerevisiae)
REACT:R-GGA-111879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 hydrolysis (Gallus gallus)
RHEA:34172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-aspartate 4-semialdehyde + pyruvate => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O
RHEA:59453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a long-chain primary fatty alcohol + NADP(+) => a long-chain fatty aldehyde + H(+) + NADPH
RHEA:60770	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A12 + 3 O2
REACT:R-GGA-202459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Bcl10 (Gallus gallus)
REACT:R-HSA-5607733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BCL10 binds CARD9 (Homo sapiens)
RHEA:56519	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fe-coproporphyrin III + 2 H(+) + 2 H2O2 <=> 2 CO2 + 4 H2O + heme b
RHEA:48647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin H2 <=> (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde
REACT:R-GGA-8851899	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Gallus gallus)
REACT:R-BTA-193143	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 hydroxylates TEST to EST17b (Bos taurus)
RHEA:14787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + RNA(n)-3'-uridine ribonucleotide => RNA(n) + UTP
REACT:R-GGA-8850997	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIM27 binds PTEN (Gallus gallus)
RHEA:16360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + succinate <=> AH2 + fumarate
REACT:R-MMU-983700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SYK binds the activated BCR (Mus musculus)
RHEA:37225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate
REACT:R-DRE-265301	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Corticotropin cleavage from POMC (Danio rerio)
REACT:R-DRE-4419979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRD5A3 reduces pPNOL to DCHOL (Danio rerio)
REACT:R-RNO-1482894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Rattus norvegicus)
REACT:R-SSC-425965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Sus scrofa)
REACT:R-RNO-5602080	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Rattus norvegicus)
REACT:R-XTR-71590	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Xenopus tropicalis)
REACT:R-HSA-1676203	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)
REACT:R-BTA-390641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADRA1A,B,D bind ADR,NAd (Bos taurus)
REACT:R-CEL-3772436	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)
RHEA:31550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (2E,6E)-farnesyl diphosphate <=> 15-cis-4,4'-diapophytoene + 2 diphosphate
REACT:R-DDI-5358597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Dictyostelium discoideum)
REACT:R-MMU-205321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of KIT and sSCF (Mus musculus)
REACT:R-BTA-2464809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RBP3 regulates the transport of atROL from ROS to RPE (Bos taurus)
GO:0042781	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ribonuclease Z activity
GO:0042781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	tRNA 3' endonuclease activity
GO:0042781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNA 3 endonuclease activity
GO:0042781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' tRNase activity
GO:0042781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3' tRNA processing endoribonuclease activity
GO:0042781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3 tRNase activity
GO:0042781	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	RNase Z activity
GO:0042781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-tRNA processing endoribonuclease activity
GO:0042781	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	tRNAse Z
RHEA:48999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-methylcatechol + O2 <=> 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)
REACT:R-SPO-1497810	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)
REACT:R-HSA-9634702	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Homo sapiens)
REACT:R-XTR-3782655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HDAC10 deacetylates histone (Xenopus tropicalis)
RHEA:64758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzylthiol + NH4(+) + pyruvate => H2O + S-benzyl-L-cysteine
RHEA:23360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP
RHEA:35917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate
REACT:R-BTA-8964333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Bos taurus)
RHEA:17923	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-xylulose + H(+) + NADH => D-arabinitol + NAD(+)
REACT:R-HSA-446204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Homo sapiens)
REACT:R-CFA-1011576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHD proteins interact with Rabenosyn-5 (Canis familiaris)
REACT:R-RNO-5688276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SIRT4 transfers ADPRib to GLUD (Rattus norvegicus)
REACT:R-HSA-4570496	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of Histone H4 with SUMO1 (Homo sapiens)
REACT:R-GGA-442387	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ZIP8 mediates zinc influx into cells (Gallus gallus)
RHEA:27984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate => 7-carboxy-7-deazaguanine + ATP + NH4(+)
RHEA:39268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)
RHEA:56271	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
GO:0001154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIIB-class transcription factor complex binding
GO:0001154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFIIIB-class transcription factor binding
REACT:R-DME-5675431	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PP2A dephosphorylates RAF1 (Drosophila melanogaster)
RHEA:27898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-AMP + H2O = adenosine + phosphate
REACT:R-RNO-3900070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of MKL1 with SUMO1 (Rattus norvegicus)
RHEA:23368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"benzoylformate decarboxylase"
RHEA:23368	skos:altLabel	"benzoylformate carboxy-lyase"
RHEA:23368	skos:prefLabel	"benzoylformate decarboxylase"
RHEA:23368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + phenylglyoxylate = benzaldehyde + CO2
REACT:R-BTA-8940100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK1 phosphorylates VCPIP1 (Bos taurus)
RHEA:20403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a substituted beta-amino acid => a beta-lactam + H2O
REACT:R-GGA-420586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Necl-1:Necl-2 trans heterodimer interaction (Gallus gallus)
REACT:R-DRE-976801	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Complement factor I complex formation (Danio rerio)
REACT:R-SSC-9011984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM1A is recruited to MYC and BCL2 genes (Sus scrofa)
RHEA:60039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate <=> 3-hydroxy-3-methylhexanoate + L-glutamine
RHEA:54225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(prostaglandin H2)-sn-glycero-3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine
RHEA:46537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-SSC-1112514	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK activation (Sus scrofa)
REACT:R-BTA-73931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Bos taurus)
REACT:R-DME-5679205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK1 phosphorylates Beclin-1 (Drosophila melanogaster)
RHEA:72175	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)
REACT:R-CEL-70941	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Caenorhabditis elegans)
REACT:R-HSA-432065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S256-Aquaporin-2 passively transports water into cell (Homo sapiens)
REACT:R-BTA-352103	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Bos taurus)
REACT:R-CFA-1676020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Canis familiaris)
REACT:R-DME-211186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of DFF45 (224) by caspase-3 (Drosophila melanogaster)
REACT:R-CEL-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Caenorhabditis elegans)
RHEA:47214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:45405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate => 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
REACT:R-XTR-9013009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA binds effectors at the plasma membrane (Xenopus tropicalis)
REACT:R-RNO-5205649	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p62 links damaged mitochondria to LC3 (Rattus norvegicus)
REACT:R-HSA-1474210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type III degradation by MMP14 (Homo sapiens)
RHEA:20272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate <=> 2 5-dehydro-4-deoxy-D-glucuronate
REACT:R-RNO-373717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DCC interacts with DIP13alpha (Rattus norvegicus)
RHEA:56778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-CFA-202132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	depalmitoylated eNOS translocates from plasma membrane (Canis familiaris)
RHEA:20828	skos:altLabel	"PS decarboxylase"
RHEA:20828	skos:altLabel	"phosphatidyl-L-serine carboxy-lyase"
RHEA:20828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylserine decarboxylase"
RHEA:20828	skos:prefLabel	"phosphatidylserine decarboxylase"
RHEA:20828	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2
REACT:R-DRE-110360	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of POLB to the AP site (Danio rerio)
RHEA:26326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine => (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine
RHEA:50051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cholate(in) + H2O <=> ADP + cholate(out) + H(+) + phosphate
REACT:R-XTR-2161768	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EXA4 is converted to EXC4 by LTC4S (Xenopus tropicalis)
RHEA:66944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C
RHEA:52697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP
REACT:R-HSA-5666160	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
REACT:R-DME-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Drosophila melanogaster)
REACT:R-DRE-6798374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DYRK2 phosphorylates TP53 (Danio rerio)
RHEA:18857	skos:altLabel	"cytochrome P450 3A10"
RHEA:18857	skos:prefLabel	"lithocholate 6beta-hydroxylase"
RHEA:18857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:18857	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lithocholate 6beta-hydroxylase"
RHEA:18857	skos:altLabel	"6beta-hydroxylase"
RHEA:18857	skos:altLabel	"lithocholate 6beta-monooxygenase"
RHEA:18857	skos:altLabel	"lithocholic acid 6beta-hydroxylase"
REACT:R-BTA-9750666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALB binds ST (Bos taurus)
RHEA:24182	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxyisobutanoyl-CoA + L-lysyl-[protein]
GO:0052634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(C-19 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)
GO:0052634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-19 gibberellin 2-beta-dioxygenase activity
GO:0052634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-19 gibberellin 2-beta-hydroxylase activity
GO:0052634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-19 GA 2-oxidase activity
GO:0052634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C(19) gibberellin 2-oxidase activity
GO:0052634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-19 gibberellin 2beta-dioxygenase activity
GO:0052634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-19 gibberellin 2beta-hydroxylase activity
GO:0052634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C-19 gibberellin 2-oxidase activity
REACT:R-HSA-9707606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PGRMC2:Hemes translocate to the nucleus (Homo sapiens)
GO:0047666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoramidate-adenosine diphosphate phosphotransferase activity
GO:0047666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:ammonia phosphotransferase activity
GO:0047666	skos:prefLabel	"ammonia kinase"
GO:0047666	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoramidate-ADP-phosphotransferase activity
GO:0047666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ammonia kinase"
GO:0047666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ammonia kinase activity
GO:0047666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + NH4(+) = ADP + 2 H(+) + phosphoramidate
REACT:R-DME-9748991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidises 6MP to 6TU (Drosophila melanogaster)
GO:0008703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
GO:0008703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aminodioxyphosphoribosylaminopyrimidine reductase activity
GO:0008703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-6-(5'-phosphoribosylamino)uracil reductase activity
GO:0008703	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity
REACT:R-CFA-5610732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI3 (Canis familiaris)
REACT:R-CFA-2028626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated MOB1A proteins associate with LATS proteins (Canis familiaris)
REACT:R-RNO-383363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Tachykinin receptor 2 (NK2) binds to nuerokinin A (Rattus norvegicus)
EC:1.1.1.3	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"homoserine dehydrogenase"
EC:1.1.1.3	skos:prefLabel	"homoserine dehydrogenase"
RHEA:46383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0016661	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors
GO:0016661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on other nitrogenous compounds as donors
GO:0016661	skos:prefLabel	"Acting on other nitrogenous compounds as donors"
GO:0016661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on other nitrogenous compounds as donors"
RHEA:71031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L-phenylalanine(in)
GO:0086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential
GO:0086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved SA node cell action potential
GO:0086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential
GO:0086059	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential
GO:0086059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential
REACT:R-MMU-5665998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MKL1 binds SRF (Mus musculus)
REACT:R-DME-197198	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Drosophila melanogaster)
REACT:R-RNO-383313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon-like Peptide 1 is secreted from intestinal L cells (Rattus norvegicus)
RHEA:69278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	but-3-enenitrile + sulfate + sulfur => (Z)-N-(sulfonatooxy)prop-2-enimidothioate
REACT:R-DRE-388596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanocortin receptors bind melanocortins (Danio rerio)
GO:0004846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + urate = 5-hydroxyisourate + H2O2
GO:0004846	skos:altLabel	"uricase"
GO:0004846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	urate:oxygen oxidoreductase activity
GO:0004846	skos:altLabel	"urate oxidase"
GO:0004846	skos:altLabel	"uric acid oxidase"
GO:0004846	skos:altLabel	"uricase II"
GO:0004846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"factor independent urate hydroxylase"
GO:0004846	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	urate oxidase activity
GO:0004846	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	uricase II activity
GO:0004846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uricase activity
GO:0004846	skos:prefLabel	"factor independent urate hydroxylase"
GO:0004846	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uric acid oxidase activity
REACT:R-RNO-9714481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 binds effectors at the ER membrane (Rattus norvegicus)
GO:0035438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic-di-GMP binding
GO:0035438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3',5'-cyclic di-GMP binding
GO:0035438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	c-di-GMP binding
GO:0035438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic dinucleotide di-GMP binding
RHEA:21763	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3S)-3-hydroxybutanoyl-CoA <=> (3R)-3-hydroxybutanoyl-CoA
RHEA:60298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine
RHEA:46951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP + S-adenosyl-L-methionine <=> N(7)-methyl-GTP + S-adenosyl-L-homocysteine
RHEA:63097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ilicicolin A epoxide => ilicicolin C
REACT:R-CEL-110227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of dihydrouracil by NTHL1 glycosylase (Caenorhabditis elegans)
RHEA:69792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-phenylalanyl-tRNA(Phe) + H2O => D-phenylalanine + H(+) + tRNA(Phe)
RHEA:66380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycodeoxycholate(in) + H2O = ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate
REACT:R-SSC-8982637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins binds G alpha-t (Sus scrofa)
REACT:R-MMU-8959573	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Mus musculus)
REACT:R-DRE-5674140	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAQR3 binds inactive RAFs (Danio rerio)
REACT:R-XTR-2213239	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MHC II alpha beta heterodimer (Xenopus tropicalis)
RHEA:24462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + CO2 => H(+) + malonyl-[ACP]
REACT:R-GGA-6798748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of secretory granule lumen proteins (Gallus gallus)
REACT:R-RNO-418163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Rattus norvegicus)
RHEA:20278	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an N-hydroxyarylamine => an N-acetoxyarylamine + CoA
REACT:R-CFA-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Canis familiaris)
REACT:R-DRE-1562641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Danio rerio)
RHEA:48440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
REACT:R-DRE-8848077	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTK6 phosphorylates STAP2 (Danio rerio)
RHEA:69937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(in) + Na(+)(in) => guanosine(out) + Na(+)(out)
RHEA:18523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine => licodione + S-adenosyl-L-methionine
RHEA:35357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-13-methyltetradecenoyl-CoA + H2O => 3-hydroxyisopentadecanoyl-CoA
GO:0016645	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on the CH-NH group of donors, other acceptors
GO:0016645	skos:prefLabel	"Acting on the CH-NH group of donors"
GO:0016645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on the CH-NH group of donors"
GO:0016645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on the CH-NH group of donors
REACT:R-DRE-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Danio rerio)
REACT:R-SPO-6801242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1 binds PRELID1, PRELID3A (Schizosaccharomyces pombe)
RHEA:66204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	heptanoyl-CoA + O2 = (2E)-heptenoyl-CoA + H2O2
REACT:R-RNO-1363331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of p130 (RBL2) by SCF (Skp2) (Rattus norvegicus)
REACT:R-SPO-8878815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Schizosaccharomyces pombe)
REACT:R-HSA-5362551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Homo sapiens)
REACT:R-DRE-5635861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NUMB:ITCH binds GLI1 (Danio rerio)
REACT:R-DDI-3149539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)
GO:0043682	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	copper transmembrane transporter activity, phosphorylative mechanism
GO:0043682	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	copper-translocating P-type ATPase activity
GO:0043682	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	copper exporting ATPase activity
GO:0043682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P-type divalent copper transporter activity
GO:0043682	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	copper-transporting ATPase activity
GO:0043682	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Cu2+-exporting ATPase activity
GO:0043682	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	Cu(2+)-exporting ATPase activity
GO:0043682	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	copper-exporting ATPase activity
REACT:R-DME-432426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRY is activated by light and binds to cytosolic TIM (Drosophila melanogaster)
REACT:R-RNO-6781897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP11 deubiquitinates NFKBIA (Rattus norvegicus)
REACT:R-HSA-5654399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR2 binds FRS2 (Homo sapiens)
RHEA:16276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphing-4-enine + CDP-choline <=> a sphingomyelin + CMP + H(+)
REACT:R-GGA-3928639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-EFNB binds GRB4 (Gallus gallus)
RHEA:53715	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(III)-heme b <=> beta-hematin
RHEA:70918	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine(in) + H(+)(in) <=> guanosine(out) + H(+)(out)
REACT:R-MMU-189053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Mus musculus)
RHEA:49717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 => 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)
REACT:R-GGA-6811426	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Retrograde COPI vesicles bind kinesin and microtubules (Gallus gallus)
REACT:R-MMU-2129375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Elastin cross-linking by lysyl oxidase (Mus musculus)
RHEA:17211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-formylglutarate + NH4(+) => 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O
RHEA:58012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic tetraadenylate = 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate
REACT:R-XTR-426155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Xenopus tropicalis)
REACT:R-BTA-75861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTP Binds Active Site of RNA Polymerase II (Bos taurus)
RHEA:37435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
REACT:R-SSC-9627107	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XIAP binds CASP7 (Sus scrofa)
REACT:R-GGA-5668932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK2 phosphorylates myosin regulatory light chain (MRLC) (Gallus gallus)
REACT:R-MMU-69053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC binding displaces Pol Alpha (Mus musculus)
REACT:R-HSA-74737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-IRS1,p-Y-IRS2 bind PI3K (Homo sapiens)
REACT:R-HSA-9615554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIR137 gene expression is inhibited by MECP2 and SOX2 (Homo sapiens)
RHEA:45315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin H2
RHEA:60332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine
RHEA:22894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methenyltetrahydrofolate + NADH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+)
RHEA:54405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate
REACT:R-CEL-202723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha5beta1 binds FN1 dimer (Caenorhabditis elegans)
REACT:R-HSA-392870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gs activation by prostacyclin receptor (Homo sapiens)
REACT:R-HSA-1295516	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits (Homo sapiens)
REACT:R-RNO-1475025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Rattus norvegicus)
EC:1.2.99.10	skos:prefLabel	"4,4'-diapolycopenoate synthase"
EC:1.2.99.10	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4,4'-diapolycopenoate synthase"
EC:1.2.99.10	skos:altLabel	"4,4'-diapolycopenealdehyde oxidase"
RHEA:60606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-tetradecanoyl-sn-glycero-3-phosphocholine
REACT:R-DDI-6801250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Dictyostelium discoideum)
RHEA:46061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CFA-3249371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TBK1 phosphorylates STAT6 at Ser407 (Canis familiaris)
RHEA:51742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A
RHEA:13345	skos:altLabel	"CAAX farnesyltransferase"
RHEA:13345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]
RHEA:13345	skos:altLabel	"FTase"
RHEA:13345	skos:prefLabel	"protein farnesyltransferase"
RHEA:13345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protein farnesyltransferase"
REACT:R-BTA-425483	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC4A5,7,9 cotransport Na+ with 3HCO3- (Bos taurus)
RHEA:16585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipoyl synthase"
RHEA:16585	skos:altLabel	"lipoate synthase"
RHEA:16585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:16585	skos:prefLabel	"lipoyl synthase"
RHEA:47231	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]
REACT:R-RNO-1474197	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II degradation by MMP1,3,8,13,PRSS2 (Rattus norvegicus)
REACT:R-HSA-5633241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Homo sapiens)
REACT:R-SSC-2730851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SLP-76 by p-SYK (Sus scrofa)
REACT:R-XTR-70600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Xenopus tropicalis)
REACT:R-BTA-5676133	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD74 binds MIF (Bos taurus)
RHEA:23121	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dipeptide(out) + ATP + H2O => a dipeptide(in) + ADP + H(+) + phosphate
REACT:R-CFA-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Canis familiaris)
RHEA:16685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	di-trans,poly-cis-dolichol + hexadecanoyl-CoA = a dolichyl hexadecanoate + CoA
RHEA:16685	skos:prefLabel	"dolichol O-acyltransferase"
RHEA:16685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dolichol O-acyltransferase"
REACT:R-PFA-8865637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MFSD2A transports LPC from extracellular region to plasma membrane (Plasmodium falciparum)
RHEA:46613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
REACT:R-DME-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Drosophila melanogaster)
REACT:R-DRE-9748999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Danio rerio)
RHEA:18645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 putrescine = NH4(+) + sym-homospermidine
RHEA:37415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA
REACT:R-XTR-201631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Desmoglein 3 (Xenopus tropicalis)
RHEA:63662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+) => (8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein]
REACT:R-RNO-376123	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSCAM associates with Rac1-GTP:pPAK1 (Rattus norvegicus)
REACT:R-HSA-178208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMAD7 binds to SMURF2 (Homo sapiens)
REACT:R-MMU-5228992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROCK1,ROCK2 are activated (Mus musculus)
REACT:R-BTA-70938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Bos taurus)
RHEA:11874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin] => corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:53021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a plastoquinone + an L-alpha-amino acid + H2O => a 2-oxocarboxylate + a plastoquinol + NH4(+)
REACT:R-CFA-1614546	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sulfate is exported to the cytosol in exchange for dicarboxylate (Canis familiaris)
GO:0048270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAT regulator activity
GO:0048270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methionine adenosyltransferase regulator activity
GO:0052587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diacetyl reductase ((R)-acetoin forming) activity
GO:0052587	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-acetoin dehydrogenase activity
RHEA:41985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + propan-2-ol => acetone + H(+) + NADH
REACT:R-CFA-165179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TSC1:TSC2 complex (Canis familiaris)
REACT:R-CFA-5696074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGK:Mg2+ phosphorylates MAG, DAG (Canis familiaris)
RHEA:71865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurodeoxycholate(in) => taurodeoxycholate(out)
RHEA:43554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O
REACT:R-MMU-162657	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of Myt1 kinase (Mus musculus)
REACT:R-CFA-6783238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Canis familiaris)
RHEA:70692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(out) + glycine(out) + 2 Na(+)(out) => chloride(in) + glycine(in) + 2 Na(+)(in)
RHEA:50743	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + leukotriene C4 <=> glycine + leukotriene F4
RHEA:34327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-nitrophenol + H(+) + NADPH + O2 = 1,4-benzoquinone + H2O + NADP(+) + nitrite
RHEA:34327	skos:prefLabel	"4-nitrophenol 4-monooxygenase"
RHEA:34327	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-nitrophenol 4-monooxygenase"
REACT:R-HSA-174493	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of ENV polyprotein (Homo sapiens)
REACT:R-CFA-113411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Canis familiaris)
REACT:R-HSA-8868661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
REACT:R-GGA-984689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesin-7 is a dimer (Gallus gallus)
REACT:R-CFA-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Canis familiaris)
REACT:R-HSA-9009403	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF1 polyubiquitinates RUNX2 (Homo sapiens)
RHEA:65333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + O2 + verruculide A => chrodrimanin E + H2O + NADP(+)
REACT:R-RNO-73945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)
REACT:R-MMU-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Mus musculus)
REACT:R-MMU-352268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Satb1 (Mus musculus)
EC:2.7.11.24	skos:altLabel	"JNK"
EC:2.7.11.24	skos:altLabel	"MBP kinase I"
EC:2.7.11.24	skos:altLabel	"stress-activated protein kinase"
EC:2.7.11.24	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"mitogen-activated protein kinase"
EC:2.7.11.24	skos:altLabel	"myelin basic protein kinase"
EC:2.7.11.24	skos:prefLabel	"mitogen-activated protein kinase"
EC:2.7.11.24	skos:altLabel	"ERK"
EC:2.7.11.24	skos:altLabel	"c-Jun N-terminal kinase"
EC:2.7.11.24	skos:altLabel	"SAPK"
EC:2.7.11.24	skos:altLabel	"microtubule-associated protein 2 kinase"
EC:2.7.11.24	skos:altLabel	"microtubule-associated protein kinase"
EC:2.7.11.24	skos:altLabel	"MAPK"
EC:2.7.11.24	skos:altLabel	"MAP kinase"
EC:2.7.11.24	skos:altLabel	"MBP kinase II"
EC:2.7.11.24	skos:altLabel	"extracellular signal-regulated kinase"
REACT:R-DDI-5674130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Dictyostelium discoideum)
RHEA:47559	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + taurodeoxycholate <=> deoxycholate + taurine
REACT:R-DME-1855177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)
GO:0032552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxyribonucleotide binding
REACT:R-MMU-9757010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Mus musculus)
REACT:R-HSA-9007464	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The PRC1L4 complex binds the UXT gene promoter (Homo sapiens)
REACT:R-HSA-975142	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Homo sapiens)
RHEA:44895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose <=> an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP
REACT:R-CEL-388824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPRF, PTPRS, PTPRD bind Liprins (Caenorhabditis elegans)
RHEA:64186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + L-tyrosine => H2O + N-(9Z-octadecenoyl)-L-tyrosine
REACT:R-XTR-3165230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC52A1,2,3 transport RIB from extracellular region to cytosol (Xenopus tropicalis)
RHEA:33164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-nicotinamide D-riboside(in) => beta-nicotinamide D-riboside(out)
REACT:R-SSC-5696131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AOC1 deaminates Hist (Sus scrofa)
REACT:R-SSC-9714959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF-alpha inhibitors bind to TNF(1-233) trimer (Sus scrofa)
RHEA:36456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanylglycine(out) => ADP + H(+) + L-alanylglycine(in) + phosphate
RHEA:54498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + ent-atiserene => ent-copalyl diphosphate
RHEA:71041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine(out) + L-phenylalanine(in) => L-methionine(in) + L-phenylalanine(out)
RHEA:47901	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate
RHEA:17232	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + an aliphatic alcohol <=> an acetyl ester + CoA
EC:4.1.3.16	skos:altLabel	"KHGA"
EC:4.1.3.16	skos:altLabel	"2-keto-4-hydroxyglutarate aldolase"
EC:4.1.3.16	skos:prefLabel	"4-hydroxy-2-oxoglutarate aldolase"
EC:4.1.3.16	skos:altLabel	"4-hydroxy-2-oxoglutarate glyoxylate-lyase"
EC:4.1.3.16	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-hydroxy-2-oxoglutarate aldolase"
EC:4.1.3.16	skos:altLabel	"2-oxo-4-hydroxyglutarate aldolase"
EC:4.1.3.16	skos:altLabel	"KHG-aldolase"
REACT:R-DRE-8868236	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BAR domain proteins recruit dynamin (Danio rerio)
RHEA:38821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine
GO:0005149	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	IL-1
GO:0005149	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	interleukin-1 receptor ligand
GO:0005149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	interleukin-1 receptor binding
RHEA:35587	skos:prefLabel	"FMN hydrolase"
RHEA:35587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"FMN hydrolase"
RHEA:35587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FMN + H2O = phosphate + riboflavin
RHEA:35587	skos:altLabel	"FMN phosphatase"
RHEA:69714	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O <=> beta-D-glucose + N-hexadecanoylsphinganine
REACT:R-CFA-9728723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Canis familiaris)
RHEA:23083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-rhamnonate <=> 2-dehydro-3-deoxy-L-rhamnonate + H2O
REACT:R-XTR-983427	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of peptide bound class I MHC on cell surface (Xenopus tropicalis)
EC:7.4.2.-	skos:prefLabel	"Linked to the hydrolysis of a nucleoside triphosphate"
EC:7.4.2.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Linked to the hydrolysis of a nucleoside triphosphate"
REACT:R-DRE-914012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Danio rerio)
REACT:R-CFA-9629470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Canis familiaris)
RHEA:54738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine
GO:0050560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nondiscriminating aspartyl-tRNA synthetase activity
GO:0050560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-tRNA(Asn) ligase activity
GO:0050560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-tRNAAsn ligase activity
GO:0050560	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate:tRNAAsx ligase (AMP-forming)
RHEA:31740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 4'-hydroxyisoflavone + S-adenosyl-L-methionine => a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine
RHEA:44605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)
RHEA:65045	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cyanobenzyl alcohol + NAD(+) => 4-cyanobenzaldehyde + H(+) + NADH
RHEA:41540	skos:prefLabel	"8-demethyl-8-alpha-L-rhamnosyl tetracenomycin-C 2'-O-methyltransferase"
RHEA:41540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine
RHEA:41540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"8-demethyl-8-alpha-L-rhamnosyl tetracenomycin-C 2'-O-methyltransferase"
RHEA:21375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + H2O + urethane <=> CO2 + ethanol + NH4(+)
REACT:R-HSA-5358518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Homo sapiens)
REACT:R-MMU-162683	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Mus musculus)
REACT:R-MMU-183094	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42:GTP binds CBL:Beta-Pix (Mus musculus)
RHEA:23975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-glutaconyl-CoA + H(+) + Na(+)(in) <=> (2E)-butenoyl-CoA + CO2 + Na(+)(out)
RHEA:28525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate
REACT:R-GGA-1296037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of Ca2+ activated Potassium channels with large conductance (Gallus gallus)
REACT:R-PFA-110248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of 3-methyladenine by MPG glycosylase  (Plasmodium falciparum)
REACT:R-DRE-5694563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABHD10 hydrolyses MPAG (Danio rerio)
REACT:R-CFA-156826	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of L13a from the 60s ribosomal subunit (Canis familiaris)
REACT:R-XTR-444100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PROT mediates L-proline uptake (Xenopus tropicalis)
RHEA:30915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine
RHEA:36862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA
RHEA:48268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4',4'-dihydroxyechinenone = canthaxanthin + H2O
REACT:R-MMU-5622134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CRABP1 binds atRA (Mus musculus)
RHEA:23670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase] => apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin
RHEA:18852	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
GO:0035596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTase
GO:0035596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	methylthiotransferase activity
RHEA:71110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(out) + S-methylmercury-L-cysteine(in) <=> L-leucine(in) + S-methylmercury-L-cysteine(out)
RHEA:34090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester
REACT:R-BTA-9688838	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds STUB1 (Bos taurus)
REACT:R-XTR-1306965	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Xenopus tropicalis)
RHEA:30841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetyl-beta-L-fucosamine => UDP-2-acetamido-2,6-dideoxy-beta-L-talose
RHEA:11333	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + RNA(n) => diphosphate + RNA(n)-3'-adenine ribonucleotide
REACT:R-MMU-6792445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPH, I hydrolyse PA to 2-acyl LPA (Mus musculus)
REACT:R-MMU-183058	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of CBL (EGFR:GRB2:CBL) (Mus musculus)
RHEA:62751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + lovastatin <=> (S)-2-methylbutanoate + H(+) + monacolin J
REACT:R-GGA-8862700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMKLR1 binds Resolvin E1 (Gallus gallus)
REACT:R-DME-6805981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HMGB1 release from cells (Drosophila melanogaster)
REACT:R-PFA-983153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E1 mediated ubiquitin activation (Plasmodium falciparum)
REACT:R-HSA-186819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SH2 domain of Src binds to the active receptor (Homo sapiens)
RHEA:22622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-indoleglycolaldehyde + CO2 + NH4(+) => H(+) + L-tryptophan + O2
REACT:R-SPO-5652172	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1B1 reduces Glc to D-sorbitol (Schizosaccharomyces pombe)
RHEA:66955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose <=> alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)
REACT:R-MMU-8948015	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Mus musculus)
REACT:R-CFA-2028692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK4 (p-MST1) by caspase 3 (Canis familiaris)
REACT:R-BTA-8963915	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,25(OH)2D binds VDR (Bos taurus)
REACT:R-HSA-375138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDO binds BOC (Homo sapiens)
REACT:R-BTA-9021079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PalmS-ESRs:CAVs translocate to plasma membrane (Bos taurus)
REACT:R-RNO-6784393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Rattus norvegicus)
REACT:R-CFA-5654669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Canis familiaris)
REACT:R-RNO-9731393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EDNRA, EDNRB bind non-selective ERAs (Rattus norvegicus)
RHEA:29126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrate(out) + ubiquinol-8(in) <=> H2O(out) + nitrite(out) + ubiquinone-8(in)
REACT:R-GGA-114552	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Thrombin-activated PARs activate G12/13 (Gallus gallus)
REACT:R-RNO-1855225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Rattus norvegicus)
REACT:R-MMU-879585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Mus musculus)
REACT:R-XTR-110246	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Xenopus tropicalis)
REACT:R-HSA-9621035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EGR1 binds the TF gene (Homo sapiens)
RHEA:41778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0)
REACT:R-RNO-3788745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EHMT1:EHMT2 methylates IL8 promoter (Rattus norvegicus)
REACT:R-XTR-113407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DSIF complex binds to RNA Pol II (hypophosphorylated) (Xenopus tropicalis)
REACT:R-HSA-8956676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YAP1 binds TP73 (Homo sapiens)
GO:0047693	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	ATP diphosphohydrolase
GO:0047693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP pyrophosphatase activity
GO:0047693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP diphosphatase activity
GO:0047693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP diphosphohydrolase (diphosphate-forming)
GO:0047693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine triphosphate pyrophosphatase activity
REACT:R-CEL-109701	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PDPK1 binds PIP3 (Caenorhabditis elegans)
RHEA:37738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
REACT:R-SSC-450466	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AUF1:mRNA complex is destroyed (Sus scrofa)
RHEA:13612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)
REACT:R-CEL-983156	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polyubiquitination of substrate (Caenorhabditis elegans)
REACT:R-BTA-9604308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD4 traffics to the nucleus (Bos taurus)
RHEA:66245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H(+) + IC-asc-C9 => diphosphate + IC-asc-C9-AMP
REACT:R-XTR-8848585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Xenopus tropicalis)
REACT:R-XTR-879930	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	STAT5 is recruited by JAK2 (Xenopus tropicalis)
REACT:R-DRE-428007	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled histidine and di-peptide cotransport (Danio rerio)
REACT:R-SSC-9009309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds STUB1 (Sus scrofa)
REACT:R-CFA-8950398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CANX dissociates from IL27:EBI3 (Canis familiaris)
REACT:R-HSA-913529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)
REACT:R-XTR-879594	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO4C1 mediates the transport of digoxin (Xenopus tropicalis)
REACT:R-HSA-1169395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ISGylation of viral protein NS1 (Homo sapiens)
RHEA:43638	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+)
GO:0070324	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	triiodothyronine binding
GO:0070324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	thyroid hormone binding
GO:0070324	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	thyroxine binding
RHEA:70268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydrogencarbonate(in) + Na(+)(in) => hydrogencarbonate(out) + Na(+)(out)
RHEA:42920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"16S rRNA (uracil(1498)-N(3))-methyltransferase"
RHEA:42920	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine
RHEA:42920	skos:prefLabel	"16S rRNA (uracil(1498)-N(3))-methyltransferase"
RHEA:42920	skos:altLabel	"m(3)U(1498) specific methyltransferase"
REACT:R-HSA-5693092	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Unknown deacetylase deacetylates 7K-BACE1(46-501) (Homo sapiens)
RHEA:50908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O
RHEA:50908	skos:prefLabel	"3-demethoxyubiquinol 3-hydroxylase"
RHEA:50908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-demethoxyubiquinol 3-hydroxylase"
RHEA:50908	skos:altLabel	"6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol 5-hydroxylase"
REACT:R-SSC-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Sus scrofa)
GO:0033760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity
GO:0033760	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-deoxymugineic-acid 2'-dioxygenase activity
GO:0033760	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	IDS3
GO:0004383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanylyl cyclase activity
GO:0004383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCYs converts GTP to cGMP (Homo sapiens)
GO:0004383	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanylate cyclase activity
GO:0004383	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	receptor guanylate cyclase activity
GO:0004383	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP diphosphate-lyase (cyclizing) activity
GO:0004383	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity
GO:0004383	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanyl cyclase activity
REACT:R-RNO-9699581	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT-phosphorylated FOXO3 translocates to cytosol (Rattus norvegicus)
RHEA:28747	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+)(in) = NH4(+)(out)
REACT:R-SSC-8937807	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SRC phosphorylates RUNX3 (Sus scrofa)
RHEA:40003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ent-copalyl diphosphate = (Z)-biformene + diphosphate
REACT:R-XTR-5607735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)
REACT:R-HSA-825631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)
REACT:R-DRE-422454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Polysialylation of NCAM1 (Danio rerio)
GO:0050298	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)
GO:0050298	skos:prefLabel	"stizolobinate synthase"
GO:0050298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stizolobinate synthase"
GO:0050298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	stizolobinate synthase activity
GO:0050298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-dopa + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)
REACT:R-DME-5689950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Drosophila melanogaster)
REACT:R-MMU-392748	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L1 binds to AP-2 Clathrin complex (Mus musculus)
RHEA:51916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-amino-3-butenoate + H2O = 2-oxobutanoate + NH4(+)
REACT:R-CEL-442291	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VAV2 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)
REACT:R-HSA-9645442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Homo sapiens)
RHEA:47619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ethionamide + H(+) + NADPH + O2 <=> ethionamide S-oxide + H2O + NADP(+)
REACT:R-RNO-1475435	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Rattus norvegicus)
REACT:R-HSA-5678822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CFTR does not transport Cl- from cytosol to extracellular region (Homo sapiens)
REACT:R-HSA-442586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of WASP and N-WASP by CDC42 (Homo sapiens)
REACT:R-CEL-2328037	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin-1 binds integrins (Caenorhabditis elegans)
REACT:R-CFA-9758661	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Canis familiaris)
GO:0102621	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity
REACT:R-BTA-68914	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA polymerase alpha:primase binds at the origin (Bos taurus)
REACT:R-HSA-8871193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
EC:3.3.2.11	skos:altLabel	"cholesterol-epoxide hydrolase"
EC:3.3.2.11	skos:prefLabel	"cholesterol-5,6-oxide hydrolase"
EC:3.3.2.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cholesterol-5,6-oxide hydrolase"
EC:3.3.2.11	skos:altLabel	"ChEH"
REACT:R-BTA-5684261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAP3K8 is phosphorylated (Bos taurus)
REACT:R-SSC-173740	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to C3(H2O) (Sus scrofa)
RHEA:19788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + dihydroclavaminate + O2 <=> clavaminate + CO2 + H2O + succinate
REACT:R-CEL-5615668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKR1C3 reduces atRAL to atROL (Caenorhabditis elegans)
REACT:R-MMU-2186771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF111 binds SMAD7 (Mus musculus)
REACT:R-MMU-8867613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PICALM binds R-SNAREs (Mus musculus)
REACT:R-XTR-9753277	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SULT dimers sulfate APAP to APAP-SO3 (Xenopus tropicalis)
REACT:R-CFA-2161950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Canis familiaris)
RHEA:68843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate
REACT:R-DME-265177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocyst complex formation (Drosophila melanogaster)
RHEA:57073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxoisoapionate 4-phosphate + H(+) => CO2 + L-erythrulose 1-phosphate
REACT:R-MMU-449829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL11 binds IL11RA (Mus musculus)
RHEA:29478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate <=> (+)-cubenene + diphosphate
REACT:R-HSA-111870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of PLC beta-1/4 (Homo sapiens)
RHEA:21261	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (R)-S-oxide
RHEA:70792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(in) + L-ornithine(out) => H(+)(out) + L-ornithine(in)
RHEA:46074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexadecanoyl-CoA + NAD(+) => (2E)-hexadecenoyl-CoA + H(+) + NADH
REACT:R-CEL-9708866	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pro-F2R binds vorapaxar (Caenorhabditis elegans)
RHEA:69041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 => 2-nitrobutanedioate + H2O + NADP(+)
REACT:R-BTA-975902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Bos taurus)
REACT:R-DRE-1676204	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Danio rerio)
REACT:R-RNO-8852200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Inactivation of LCK by PTPN22 (Rattus norvegicus)
REACT:R-BTA-2167942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type XIII ectodomain shedding (Bos taurus)
REACT:R-RNO-975629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH11 reduces RBP2:atRAL to RBP2:atROL (Rattus norvegicus)
RHEA:40611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + trihexanoylglycerol = 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate
REACT:R-HSA-420591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nectin-2:Nectin 3 trans heterodimer interaction (Homo sapiens)
REACT:R-HSA-9694287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of S protein into S1:S2 (Homo sapiens)
REACT:R-HSA-8936356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCY2C trimer binds sta1 (Homo sapiens)
REACT:R-CFA-2730835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PKC-theta (Canis familiaris)
RHEA:31874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene <=> alpha-seco-amyrin
REACT:R-BTA-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)
REACT:R-DRE-741450	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC35A3 exchanges UDP-GlcNAc for UMP (Danio rerio)
REACT:R-BTA-6811412	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active ARF recruits coatomer to the Golgi (Bos taurus)
REACT:R-MMU-5610732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GSK3 phosphorylates p-GLI3 (Mus musculus)
REACT:R-BTA-6814682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of early-endosome derived vesicles at the TGN (Bos taurus)
REACT:R-CEL-9748951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)
REACT:R-RNO-3321805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSL acetylates histone H4 (Rattus norvegicus)
RHEA:71250	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanine(out) + chloride(out) + 2 Na(+)(out) <=> beta-alanine(in) + chloride(in) + 2 Na(+)(in)
REACT:R-RNO-170088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Rattus norvegicus)
REACT:R-XTR-6781824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Active RNA Pol II complex transcribes lesion-containing DNA template (Xenopus tropicalis)
REACT:R-DRE-5694433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MIA2 binds PREB (Danio rerio)
RHEA:52608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-hydroxybutanoate + NADP(+) = 2-oxobutanoate + H(+) + NADPH
RHEA:43967	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
REACT:R-BTA-429815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation Of Bloc-1 Complex (Bos taurus)
GO:0008942	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nitrite reductase [NAD(P)H] activity
GO:0008942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ammonium-hydroxide:NAD(P)+ oxidoreductase activity
GO:0008942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H:nitrite oxidoreductase activity
GO:0008942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	assimilatory nitrite reductase activity
GO:0008942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADPH-nitrite reductase activity
GO:0008942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NAD(P)H2:nitrite oxidoreductase activity
GO:0008942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity
GO:0008942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NADH-nitrite oxidoreductase activity
GO:0008942	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	nitrite reductase [NAD(P)H2]
RHEA:60676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-(-)-citronellol + NAD(+) = (S)-(-)-citronellal + H(+) + NADH
GO:0050287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-ketofructose reductase activity
GO:0050287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity
GO:0050287	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sorbose 5-dehydrogenase (NADP+) activity
GO:0050287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
GO:0050287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-keto-D-fructose reductase activity
GO:0050287	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-sorbose:NADP+ 5-oxidoreductase activity
REACT:R-HSA-159101	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
RHEA:11879	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NAD(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADH
RHEA:48980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,4-dichlorocatechol + O2 = (2Z,4Z)-2,3-dichloromuconate + 2 H(+)
RHEA:23843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-(2,3-dihydroxyphenyl)propanoate + O2 <=> (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)
REACT:R-XTR-9714480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC2 translocates to the mitochondrial membrane (Xenopus tropicalis)
REACT:R-SPO-9678749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IMPDH tetramers binds IMPDH inhibitors (Schizosaccharomyces pombe)
EC:3.4.22.28	skos:altLabel	"poliovirus protease 3C"
EC:3.4.22.28	skos:altLabel	"foot-and-mouth protease 3C"
EC:3.4.22.28	skos:altLabel	"rhinovirus protease 3C"
EC:3.4.22.28	skos:altLabel	"picornavirus endopeptidase 3C"
EC:3.4.22.28	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"picornain 3C"
EC:3.4.22.28	skos:prefLabel	"picornain 3C"
REACT:R-SSC-5654717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
REACT:R-BTA-139909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Translocation of BMF to mitochondria (Bos taurus)
REACT:R-CFA-213407	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Disassociation of PLC-gamma1 from SLP-76 (Canis familiaris)
RHEA:45882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA
EC:1.5.1.49	skos:prefLabel	"1-pyrroline-2-carboxylate reductase [NAD(P)H]"
EC:1.5.1.49	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"1-pyrroline-2-carboxylate reductase [NAD(P)H]"
GO:0003833	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-alanyl-dopamine synthase activity
GO:0003833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBAD transferase activity
GO:0003833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-alanyl amine synthase activity
GO:0003833	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-beta-alanyl dopamine synthetase activity
REACT:R-RNO-3296304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPR31 is a receptor for 12(S)-HETE (Rattus norvegicus)
REACT:R-PFA-1855178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Plasmodium falciparum)
RHEA:56233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate
REACT:R-CFA-1237059	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA4:Zn2+ dehydrates HCO3- to CO2 (Canis familiaris)
REACT:R-GGA-265423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with Fibrillin (Gallus gallus)
REACT:R-RNO-8855648	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM3 binds LAR-RPTP (Rattus norvegicus)
REACT:R-BTA-8987230	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Bos taurus)
REACT:R-RNO-205262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Direct recruitment of PI3K to p-KIT (Rattus norvegicus)
REACT:R-DRE-265456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPC1L1 binds ezetimibe (Danio rerio)
EC:3.1.1.34	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"lipoprotein lipase"
EC:3.1.1.34	skos:altLabel	"clearing factor lipase"
EC:3.1.1.34	skos:altLabel	"diglyceride lipase"
EC:3.1.1.34	skos:altLabel	"diacylglycerol lipase"
EC:3.1.1.34	skos:prefLabel	"lipoprotein lipase"
REACT:R-DRE-9688459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIPK3 binds HSP90:CDC37 (Danio rerio)
RHEA:71188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-L-kynurenine(out) + L-tryptophan(in) => 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)
REACT:R-BTA-183126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor B binds to surface-associated C3b (Bos taurus)
REACT:R-RNO-201422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Rattus norvegicus)
REACT:R-XTR-8982162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Xenopus tropicalis)
RHEA:28373	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxaloacetate + phosphate <=> hydrogencarbonate + phosphoenolpyruvate
REACT:R-DDI-211910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Dictyostelium discoideum)
REACT:R-DME-9708423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XPO1:BACH1:Hemes are transported out of the nucleus (Drosophila melanogaster)
RHEA:33473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine
RHEA:70610	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + 4-ethylphenol <=> 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)
GO:0043874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)
GO:0043874	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	E-1
GO:0043874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acireductone synthase activity
GO:0043874	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	E-1 enolase-phosphatase
RHEA:41229	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxyphenylglyoxylate + H2O2 => (S)-4-hydroxymandelate + O2
REACT:R-BTA-174367	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GCL ligates L-Glu to L-Cys (Bos taurus)
RHEA:48940	skos:prefLabel	"membrane dipeptidase"
RHEA:48940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"membrane dipeptidase"
RHEA:48940	skos:altLabel	"DPH I"
RHEA:48940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid
RHEA:48940	skos:altLabel	"dehydropeptidase I"
RHEA:48940	skos:altLabel	"renal dipeptidase"
RHEA:48940	skos:altLabel	"microsomal dipeptidase"
REACT:R-HSA-4724284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Homo sapiens)
REACT:R-MMU-8987039	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	JAK1 binds IL20RA (Mus musculus)
GO:0005504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fatty acid binding
RHEA:69444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = alpha-cadinene + diphosphate
REACT:R-RNO-71146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Rattus norvegicus)
REACT:R-SSC-2485148	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Sus scrofa)
RHEA:56741	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	globoside Gb3Cer + UDP-alpha-D-galactose => GalGb3Cer + H(+) + UDP
REACT:R-MMU-9027043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYPs hydroxylate DHA to 14(R)-HDHA (Mus musculus)
REACT:R-SSC-114548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Sus scrofa)
REACT:R-HSA-5637800	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)
REACT:R-MMU-4570463	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Mus musculus)
RHEA:68803	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + nigerose <=> alpha-D-glucose + D-glucose
RHEA:58696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH + O2 + rifampicin = H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide
REACT:R-BTA-6806629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of tonofilament bundles (Bos taurus)
RHEA:64159	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-(fatty acyl)-L-methionine + H2O <=> a fatty acid + L-methionine
RHEA:68088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] = a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]
RHEA:32667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	coenzyme M + methanethiol = H(+) + hydrogen sulfide + methyl-coenzyme M
RHEA:32667	skos:prefLabel	"methylated-thiol--coenzyme M methyltransferase"
RHEA:32667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methylated-thiol--coenzyme M methyltransferase"
REACT:R-HSA-2187405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTMR4 binds phosphorylated SMAD2/3 (Homo sapiens)
REACT:R-RNO-1067640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6 binds IL6R-2 (Rattus norvegicus)
REACT:R-XTR-9649733	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	mature p21 RAS binds GDP (Xenopus tropicalis)
RHEA:69280	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate = 3-hydroxypropyl isothiocyanate + sulfate
REACT:R-DRE-3640844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF146 binds RibC-AXIN:TNKS complex (Danio rerio)
REACT:R-RNO-1676164	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Rattus norvegicus)
EC:3.4.21.115	skos:altLabel	"Vp4 protease"
EC:3.4.21.115	skos:altLabel	"IPNV Vp4 protease"
EC:3.4.21.115	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"infectious pancreatic necrosis birnavirus Vp4 peptidase"
EC:3.4.21.115	skos:altLabel	"infectious pancreatic necrosis virus protease"
EC:3.4.21.115	skos:prefLabel	"infectious pancreatic necrosis birnavirus Vp4 peptidase"
EC:3.4.21.115	skos:altLabel	"NS protease"
EC:3.4.21.115	skos:altLabel	"NS-associated protease"
EC:3.4.21.115	skos:altLabel	"IPNV Vp4 peptidase"
REACT:R-HSA-3134954	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHX9 binds DNA (Homo sapiens)
RHEA:25808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine
REACT:R-HSA-9604487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-IRF7:p-IRF7 translocates to the nucleus (Homo sapiens)
RHEA:13635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + gamma-L-glutamylputrescine + H(+) + phosphate => ATP + L-glutamate + putrescine
RHEA:36468	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-alanylglycine => glycine + L-alanine
RHEA:19364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2E,6E)-farnesyl diphosphate + diphosphate
GO:0051540	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	metal cluster binding
REACT:R-GGA-1467269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Beta-defensins bind microbial membranes causing disruption (Gallus gallus)
RHEA:71222	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Na(+)(out) + nitrate(out) <=> 2 Na(+)(in) + nitrate(in)
REACT:R-XTR-9668831	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CST complex formation (Xenopus tropicalis)
REACT:R-MMU-1483063	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PG and CDP-DAG are converted to CL by CRLS1 (Mus musculus)
REACT:R-XTR-5649802	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)
RHEA:50554	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin B1 => prostaglandin C1
REACT:R-XTR-983138	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of MHC heterotrimer to ER exit site (Xenopus tropicalis)
EC:1.1.1.418	skos:altLabel	"3beta-hydroxysteroid dehydrogenases/C-4 decarboxylase"
EC:1.1.1.418	skos:prefLabel	"plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)"
EC:1.1.1.418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)"
REACT:R-CEL-183051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL ubiquitinates Sprouty (Caenorhabditis elegans)
RHEA:29152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)
GO:0000035	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	acyl-CoA or acyl binding
GO:0000035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acyl binding
RHEA:23001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-pantoate + NAD(+) => (R)-4-dehydropantoate + H(+) + NADH
REACT:R-PFA-8876319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC50A1 transports Glc from cytosol to extracellular region (Plasmodium falciparum)
RHEA:46176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-methylpropanoate + ATP + CoA = 2-methylpropanoyl-CoA + AMP + diphosphate
RHEA:71454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bradykinin + H2O <=> bradykinin(1-7) + L-Phe-L-Arg
REACT:R-DDI-9749253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MCM2-7 complex (Dictyostelium discoideum)
REACT:R-RNO-1369017	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of ATP sensitive Potassium channels in muscle cells (Rattus norvegicus)
RHEA:54161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 => [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate
REACT:R-DME-8849906	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SALM1 binds NMDA receptor (Drosophila melanogaster)
RHEA:39729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingomyelin(out) => a sphingomyelin(in)
RHEA:51201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine => H2O + N-retinylidene-N-retinylphosphatidylethanolamine
REACT:R-CFA-158756	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Canis familiaris)
RHEA:53860	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) = dehydrocholate + H(+) + NADPH
RHEA:58001	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg3 + H(+) + UDP
RHEA:36669	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine => (15Z)-tetracosenoyl-CoA + sphinganine
REACT:R-SSC-418553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP degradation by Phosphodiesterases (Sus scrofa)
RHEA:40822	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)
REACT:R-BTA-205306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of SHP1 and KIT (Bos taurus)
REACT:R-MMU-203680	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)
RHEA:22844	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-MMU-191405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Two FPP molecules dimerize to form presqualene diphosphate (Mus musculus)
GO:0047591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-hydroxyvalerate coenzyme A transferase activity
GO:0047591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-hydroxyvalerate CoA-transferase activity
GO:0047591	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	acetyl-CoA:5-hydroxypentanoate CoA-transferase activity
GO:0047591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-hydroxypentanoate CoA-transferase activity
REACT:R-XTR-427337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MBD2 binds methylcytosine in chromatin (Xenopus tropicalis)
REACT:R-BTA-69016	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Cdc6 is degraded by the proteasome (Bos taurus)
RHEA:49791	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholoyl-CoA + glycine <=> CoA + glycochenodeoxycholate + H(+)
RHEA:50550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + prostaglandin A1 => prostaglandin E1
REACT:R-DME-9610152	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Drosophila melanogaster)
REACT:R-MMU-6807053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SC5D desaturates LTHSOL to 7-dehydroCHOL (Mus musculus)
REACT:R-RNO-8956659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates YAP1 (Rattus norvegicus)
RHEA:37847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	13-dihydrodaunorubicin + H(+) + NADPH + O2 = daunorubicin + 2 H2O + NADP(+)
RHEA:37847	skos:prefLabel	"13-deoxydaunorubicin hydroxylase"
RHEA:37847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"13-deoxydaunorubicin hydroxylase"
RHEA:16584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 <=> 2 Fe(III)-[cytochrome c] + 2 H2O
REACT:R-RNO-8987150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Rattus norvegicus)
RHEA:64032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)
GO:0030409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formiminoglutamic acid transferase activity
GO:0030409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate formimidoyltransferase activity
GO:0030409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity
GO:0030409	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	formimidoyltransferase activity
GO:0030409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate formiminotransferase activity
GO:0030409	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	formiminotransferase activity
GO:0030409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glutamate formyltransferase activity
GO:0030409	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	formiminoglutamic formiminotransferase activity
REACT:R-GGA-417843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y13 binds ADP (Gallus gallus)
REACT:R-HSA-9680865	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4, CYP2B6 bind ritonavir (Homo sapiens)
GO:0018628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	terephthalate 1,2-dioxygenase activity
GO:0018628	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzene-1,4-dicarboxylate 1,2-dioxygenase activity
GO:0018628	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	1,4-dicarboxybenzoate 1,2-dioxygenase activity
GO:0018628	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)
GO:0008481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphingosine kinase (phosphorylating)
GO:0008481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	sphingosine kinase activity
GO:0008481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrosphingosine kinase (phosphorylating)
GO:0008481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:sphinganine 1-phosphotransferase activity
GO:0008481	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dihydrosphingosine kinase activity
GO:0008481	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphinganine kinase activity
GO:0016675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on a heme group of donors
GO:0016675	skos:prefLabel	"Acting on a heme group of donors"
GO:0016675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Acting on a heme group of donors"
GO:0016675	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oxidoreductase activity, acting on haem group of donors
GO:0016675	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	oxidoreductase activity, acting on heme group of donors, other acceptors
RHEA:67996	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(Z)-1,2-dichloroethene + AH2 = A + chloride + chloroethene + H(+)
REACT:R-DRE-203070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of profilin with monomeric actin (Danio rerio)
REACT:R-GGA-69191	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of Cyclin E:Cdk2 complexes (Gallus gallus)
REACT:R-CFA-1855224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Canis familiaris)
REACT:R-XTR-165179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of TSC1:TSC2 complex (Xenopus tropicalis)
REACT:R-BTA-389639	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Bos taurus)
REACT:R-BTA-5686073	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GRB2-1:SOS1 binds p-3Y-SHC1 (Bos taurus)
RHEA:23273	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N(6)-alkylaminopurine + UDP-alpha-D-glucose => an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP
REACT:R-CEL-6811429	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Caenorhabditis elegans)
GO:0008938	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinate N-methyltransferase activity
GO:0008938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	furanocoumarin 8-O-methyltransferase activity
GO:0008938	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	S-adenosyl-L-methionine:nicotinate N-methyltransferase activity
RHEA:42050	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetoacetyl-CoA + H(+) + NADH => 3-hydroxybutanoyl-CoA + NAD(+)
RHEA:22314	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate => 5-(methylsulfanyl)-D-ribose + ATP
REACT:R-DRE-5578910	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KCNK dimers transport K+ from cytosol to extracellular region (Danio rerio)
REACT:R-HSA-8862090	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Homo sapiens)
REACT:R-MMU-9707051	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN1 binds BRCA1:BARD1 heterodimer (Mus musculus)
REACT:R-HSA-5205663	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)
RHEA:72907	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-mannose(out) + Na(+)(out) = D-mannose(in) + Na(+)(in)
REACT:R-DRE-2243931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of dehydro-lysinonorleucine cross-links (Danio rerio)
REACT:R-DRE-417842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	P2Y10 receptor can bind to LPA (Danio rerio)
REACT:R-RNO-418925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADORA2A,B bind Ade-Rib (Rattus norvegicus)
REACT:R-CEL-74248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Caenorhabditis elegans)
GO:0009679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexose:hydrogen symporter activity
GO:0009679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hexose:proton symporter activity
REACT:R-BTA-6797606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Bos taurus)
REACT:R-DRE-6814187	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EVL:PPL heterodimer binds the inner surface of the plasma membrane (Danio rerio)
RHEA:54303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate <=> n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)
REACT:R-BTA-5635839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ULK3:SUFU dissociates (Bos taurus)
REACT:R-DRE-1482667	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPE is acylated to PE by LPEAT (Danio rerio)
REACT:R-XTR-159771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Furin cleaves pro-protein C to protein C (Xenopus tropicalis)
REACT:R-RNO-419861	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Melanospin is stimulated by light (Rattus norvegicus)
GO:0003830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0003830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III
GO:0003830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity
GO:0003830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity
GO:0003830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity
GO:0003830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity
GO:0003830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N-acetylglucosaminyltransferase III activity
GO:0003830	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GnTIII activity
GO:0003830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
REACT:R-DME-68712	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Drosophila melanogaster)
REACT:R-GGA-426086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Gallus gallus)
RHEA:54346	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline
RHEA:19009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acylpyruvate hydrolase"
RHEA:19009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 3-acylpyruvate + H2O = a carboxylate + H(+) + pyruvate
RHEA:19009	skos:prefLabel	"acylpyruvate hydrolase"
RHEA:11418	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-bis-O-galloyl-beta-D-glucose + D-glucose => 2 1-O-galloyl-beta-D-glucose
RHEA:53837	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine => a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]
RHEA:42486	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-sorbitol 6-phosphate(in) + L-histidyl-[protein] => D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein]
REACT:R-SSC-1606288	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) (Sus scrofa)
REACT:R-SSC-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Sus scrofa)
REACT:R-CEL-8849348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Caenorhabditis elegans)
REACT:R-HSA-3065958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	An unknown protease degrades ACACA (Homo sapiens)
RHEA:67202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetate + tyramine => H2O + N-acetyltyramine
REACT:R-SSC-4411402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of NLK (Sus scrofa)
REACT:R-MMU-2066788	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Mus musculus)
REACT:R-XTR-173725	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	C9 binds C5b:C6:C7:C8 (Xenopus tropicalis)
GO:0008158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	patched activity
GO:0008158	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hedgehog receptor activity
GO:0017024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	myosin I binding
GO:0035237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corazonin receptor activity
RHEA:67975	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + ecdysone <=> ADP + ecdysone 22-phosphate + H(+)
REACT:R-DME-9018758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOH binds effectors at the plasma membrane (Drosophila melanogaster)
RHEA:64488	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA = 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA
RHEA:49343	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-XTR-5689000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AADAC deacetylates PHEN (Xenopus tropicalis)
GO:0004071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-asparagine synthetase activity
GO:0004071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	asparagine synthetase activity
GO:0004071	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aspartate-ammonia ligase activity
GO:0004071	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	L-aspartate:ammonia ligase (AMP-forming)
RHEA:17044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	adenosine 5'-phosphosulfate + H2O <=> AMP + 2 H(+) + sulfate
GO:0106235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ceramide-1-phosphate phosphatase activity
GO:0106235	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-acylsphingoid base 1-phosphate + H2O = an N-acyl-sphingoid base + phosphate
RHEA:11776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stearoyl-[acyl-carrier-protein] 9-desaturase"
RHEA:11776	skos:altLabel	"stearyl acyl carrier protein desaturase"
RHEA:11776	skos:prefLabel	"stearoyl-[acyl-carrier-protein] 9-desaturase"
RHEA:11776	skos:altLabel	"stearyl-ACP desaturase"
RHEA:11776	skos:altLabel	"acyl-[acyl-carrier-protein] desaturase"
RHEA:11776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-SSC-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Sus scrofa)
REACT:R-GGA-9667952	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ANKLE2 is deacetylated by SIRT2 (Gallus gallus)
RHEA:71646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	guanosine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide
RHEA:70645	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-proline(in) + H(+)(in) => D-proline(out) + H(+)(out)
RHEA:71091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)
REACT:R-MMU-2038398	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KIBRA (WWC1) binds LATS proteins (Mus musculus)
RHEA:33088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclic dehypoxanthinylfutalosinate => 1,4-dihydroxy-6-naphthoate + chemical entity
REACT:R-GGA-190258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR2c binds to FGF (Gallus gallus)
RHEA:50882	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol
RHEA:57976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside C-K + H(+) + UDP
REACT:R-CFA-202331	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of PLC-gamma1 to SLP-76 (Canis familiaris)
REACT:R-RNO-6785898	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL4R binds JAK2 (Rattus norvegicus)
REACT:R-XTR-170026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Protons are translocated from the intermembrane space to the matrix (Xenopus tropicalis)
RHEA:67569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3'-phosphoadenylyl sulfate + taurochenodeoxycholate => adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate
REACT:R-RNO-5692779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S182 MAPKAPK5 phosphorylates FOXO1 (Rattus norvegicus)
RHEA:15311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin] => (2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin]
GO:0102583	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity
RHEA:28958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aldehydo-D-glucuronate(in) + H(+)(in) <=> aldehydo-D-glucuronate(out) + H(+)(out)
RHEA:41968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)
REACT:R-DDI-917979	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
RHEA:48888	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
RHEA:55662	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 A + echinenone + 3 H2O => 2 AH2 + all-trans-beta-carotene + 2 O2
RHEA:51693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prephenate + S-adenosyl-L-methionine => 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O
REACT:R-BTA-5444523	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of MSH1:PMS2 Complex (Bos taurus)
REACT:R-MMU-9707419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Mus musculus)
GO:0050626	skos:altLabel	"trimethylamine-N-oxide reductase (cytochrome c)"
GO:0050626	skos:altLabel	"TOR"
GO:0050626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	trimethylamine:cytochrome c oxidoreductase activity
GO:0050626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TOR activity
GO:0050626	skos:prefLabel	"trimethylamine-N-oxide reductase"
GO:0050626	skos:altLabel	"TMAO reductase"
GO:0050626	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	TMAO reductase activity
GO:0050626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trimethylamine-N-oxide reductase (cytochrome c) activity
GO:0050626	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"trimethylamine-N-oxide reductase"
REACT:R-DRE-389897	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Danio rerio)
RHEA:45309	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + prostaglandin D2-ethanolamide => 11beta-prostaglandin F2-ethanolamide + NADP(+)
RHEA:24981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-4-methylanthranilate + ATP + H(+) => 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate
RHEA:33568	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + ethanol => acetaldehyde + AH2
REACT:R-BTA-114259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of Procaspase‑9 to caspase‑9 (Bos taurus)
REACT:R-HSA-9768950	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NPAS4 binds FOS gene enhancer (Homo sapiens)
REACT:R-MMU-8952371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 binds RUNX3 (Mus musculus)
RHEA:35338	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isopentadecanoyl-CoA + malonyl-CoA <=> 3-oxoisoheptadecanoyl-CoA + CO2 + CoA
RHEA:30932	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + O-acetyl-L-homoserine => acetate + H(+) + L,L-cystathionine
REACT:R-DRE-174444	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of C-strand Okazaki fragments (Danio rerio)
RHEA:71207	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)
GO:0102124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A12 16alpha,17 epoxidase activity
RHEA:59074	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine
REACT:R-SCE-507868	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporins passively transport water into cells (Saccharomyces cerevisiae)
RHEA:70845	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(out) + L-methionine(in) + Na(+)(in) => L-arginine(in) + L-methionine(out) + Na(+)(out)
RHEA:58778	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + pyridine-3-carbaldehyde => NADP(+) + pyridine 3-methanol
REACT:R-RNO-549279	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OCT2 mediates tubular uptake of organic cations in the kidney (Rattus norvegicus)
RHEA:62190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	diphosphate + syn-isopimara-7,15-diene => 9alpha-copalyl diphosphate
RHEA:40210	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-tetradecenedioyl-CoA + H2O <=> (3S)-hydroxytetradecanedioyl-CoA
REACT:R-CEL-8948757	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT phosphorylates MKRN1 (Caenorhabditis elegans)
RHEA:14192	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tryptophan + O2 <=> N-formyl-D-kynurenine
REACT:R-CFA-382575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Canis familiaris)
REACT:R-SSC-9027627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Sus scrofa)
REACT:R-SSC-2022405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)
REACT:R-HSA-879917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
REACT:R-MMU-9648114	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EML4 recruits NUDC to mitotic spindle (Mus musculus)
EC:3.1.6.13	skos:altLabel	"chondroitinsulfatase"
EC:3.1.6.13	skos:prefLabel	"iduronate-2-sulfatase"
EC:3.1.6.13	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"iduronate-2-sulfatase"
GO:0015574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose permease activity
GO:0015574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trehalose transmembrane transporter activity
GO:0015574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)
REACT:R-HSA-167601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Degradation of CD4 (Homo sapiens)
REACT:R-DME-77615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR2) (Drosophila melanogaster)
REACT:R-DRE-4641205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSPO:LGR binds ZNRF3 (Danio rerio)
REACT:R-DME-3928624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPHBs bind EFNBs (Drosophila melanogaster)
REACT:R-DME-6814409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 phosphorylates PDCL (Drosophila melanogaster)
REACT:R-MMU-9631987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLCO1B1 transports T3,T4 from extracellular region to cytosol (Mus musculus)
REACT:R-SSC-1307955	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR4 binds HS:KLB:FGF19 (Sus scrofa)
REACT:R-CFA-977371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor I inactivates Factor H-boundC3b (Canis familiaris)
REACT:R-MMU-3247843	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	secretion of WNT ligands (Mus musculus)
REACT:R-RNO-193703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IKKbeta is activated (Rattus norvegicus)
EC:5.4.2.11	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)"
EC:5.4.2.11	skos:altLabel	"phosphoglycerate phosphomutase"
EC:5.4.2.11	skos:altLabel	"cofactor dependent phosphoglycerate mutase"
EC:5.4.2.11	skos:altLabel	"PGAM"
EC:5.4.2.11	skos:altLabel	"2,3-diphosphoglycerate dependent phosphoglycerate mutase"
EC:5.4.2.11	skos:altLabel	"phosphoglyceromutase"
EC:5.4.2.11	skos:prefLabel	"phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)"
REACT:R-GGA-419841	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Light stimulates opsin receptors (Gallus gallus)
REACT:R-GGA-5696968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)
REACT:R-SSC-5368596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Sus scrofa)
REACT:R-SSC-264679	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serum albumin binds 2-lysophosphatidylcholine (Sus scrofa)
REACT:R-GGA-210304	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of integrin alphaVbeta3 with PECAM1 (Gallus gallus)
REACT:R-SSC-1364044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRLR:JAK2 dimerizes (Sus scrofa)
REACT:R-CEL-74734	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Re-integration of insulin receptor into plasma membrane (Caenorhabditis elegans)
REACT:R-RNO-9692539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HRH1 binds HRH1 inverse agonists (Rattus norvegicus)
RHEA:22052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxylamine reductase"
RHEA:22052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine
RHEA:22052	skos:altLabel	"hydroxylamine (acceptor) reductase"
RHEA:22052	skos:prefLabel	"hydroxylamine reductase"
RHEA:26253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + isopimara-7,15-dienol + NADPH + O2 = 2 H2O + isopimara-7,15-dienal + NADP(+)
REACT:R-GGA-879909	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of STAT5a/b by JAK2 (Gallus gallus)
REACT:R-GGA-158484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of the SLBP independent Histone mRNA from the NPC (Gallus gallus)
RHEA:50414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein]
REACT:R-RNO-75889	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DHAP is converted to G3P by GPD1/GPD1L (Rattus norvegicus)
RHEA:17442	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-glutamate
REACT:R-DDI-430028	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Dictyostelium discoideum)
RHEA:41851	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E)-octenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octanoyl-[ACP]
REACT:R-MMU-71218	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Mus musculus)
REACT:R-DME-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Drosophila melanogaster)
REACT:R-MMU-3296244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUCNR1 binds SUCCA (Mus musculus)
REACT:R-SSC-445753	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Sus scrofa)
REACT:R-SSC-5218827	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADPH oxidase 2 (NOX2) complex binds RAC1 (Sus scrofa)
REACT:R-SSC-1793186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Sus scrofa)
RHEA:34290	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 L-dopa + O2 <=> 2 H2O + 2 L-dopaquinone
REACT:R-MMU-8982163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)
RHEA:59408	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-L-aspartate = acetate + L-aspartate
REACT:R-GGA-266350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CETP-mediated lipid exchange: LDL gains cholesterol ester (Gallus gallus)
REACT:R-DRE-2424487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of PLC-gamma by p-BTK/p-SYK (Danio rerio)
RHEA:16223	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine
REACT:R-BTA-8852131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Bos taurus)
REACT:R-SSC-5691167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CUL1, SKP1, FBXL5 bind (Sus scrofa)
RHEA:53031	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	lithocholate + UDP-alpha-D-glucuronate <=> H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP
REACT:R-HSA-5580292	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective CYP11B1 does not oxidise 11DCORT (Homo sapiens)
RHEA:52751	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-isomaltosyl-(1->3)-isomaltose + H2O <=> 2 isomaltose
RHEA:45181	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 (E)-4-coumaroyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine
REACT:R-SSC-202453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Sus scrofa)
REACT:R-RNO-163320	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of mTERF with the termination sequence (Rattus norvegicus)
RHEA:36758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP
REACT:R-DRE-446188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Danio rerio)
RHEA:31341	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-[ACP] + AMP + diphosphate => acetate + ATP + holo-[ACP]
REACT:R-MMU-9758088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Mus musculus)
RHEA:50537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	prostaglandin E2 => H2O + prostaglandin A2
RHEA:21201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + L-lysine => (S)-2-amino-6-oxohexanoate + L-glutamate
REACT:R-SSC-5696958	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP44 deubiquitinates CDC20 (Sus scrofa)
REACT:R-BTA-3769392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Bos taurus)
REACT:R-DRE-9704297	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHRM2 binds CHRM2 antagonists (Danio rerio)
REACT:R-BTA-114689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)
REACT:R-MMU-909729	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of JAK kinases (Mus musculus)
RHEA:50060	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glycochenodeoxycholate(in) + H2O = ADP + glycochenodeoxycholate(out) + H(+) + phosphate
REACT:R-HSA-9707186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ALOX5 binds ALOX5 inhibitors (Homo sapiens)
REACT:R-XTR-202723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alpha5beta1 binds FN1 dimer (Xenopus tropicalis)
REACT:R-CFA-2534359	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CatSper Channel Mediated Calcium Transport (Canis familiaris)
RHEA:14541	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choloyl-CoA + H2O = cholate + CoA + H(+)
REACT:R-HSA-8869607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NAR to yield NAMN (Homo sapiens)
REACT:R-BTA-8854908	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PKA phosphorylates RET:GDNF:GFRA dimer (Bos taurus)
REACT:R-MMU-4332356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK2 binds MAP3K7 (Mus musculus)
RHEA:14605	skos:prefLabel	"alpha,alpha-trehalose-phosphate synthase (GDP-forming)"
RHEA:14605	skos:altLabel	"trehalose phosphate synthase (GDP-forming)"
RHEA:14605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"alpha,alpha-trehalose-phosphate synthase (GDP-forming)"
RHEA:14605	skos:altLabel	"GDP-glucose-glucosephosphate glucosyltransferase"
RHEA:14605	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose 6-phosphate + GDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + GDP + H(+)
RHEA:33174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-maltose(in) <=> D-maltose(out)
REACT:R-XTR-2179274	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds SMAD3 phosphorylated in the linker region (Xenopus tropicalis)
REACT:R-GGA-5694425	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NSF ATPase activity dissociates cis-SNARE (Gallus gallus)
REACT:R-HSA-164524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Fusion of viral membrane with host cell membrane (Homo sapiens)
RHEA:17088	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-pyridoxate + A <=> 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2
REACT:R-RNO-2465940	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	atRAL is reduced to atROL (Rattus norvegicus)
REACT:R-HSA-8869560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)
RHEA:38820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
RHEA:57919	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-aspartyl-tRNA(Asn) <=> 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)
REACT:R-MMU-622310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated NOD1 oligomerizes (Mus musculus)
REACT:R-BTA-2267372	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Bos taurus)
RHEA:13867	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol
RHEA:26126	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-1-pyrroline-5-carboxylate + FADH2 => FAD + L-proline
RHEA:20917	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + sulfite => hydrogen sulfide + L-cysteate
REACT:R-DRE-416985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trafficking of GluR2-containing AMPA receptors to synapse (Danio rerio)
RHEA:59980	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	8-oxo-dGTP + H2O = 8-oxo-dGDP + H(+) + phosphate
RHEA:11392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
RHEA:21814	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]
RHEA:33948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine => 2'-N-acetylparomamine + H(+) + UDP
RHEA:48013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-methyl-5-nitrocatechol + NADPH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite
REACT:R-RNO-190782	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Budding of connexon-containing transport vesicles from the Golgi (Rattus norvegicus)
RHEA:61693	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP => AMP + L-threonyl-[peptidyl-carrier protein]
RHEA:21591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH
RHEA:64691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP
REACT:R-DRE-8864595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2B homodimer binds YEATS4 (Danio rerio)
REACT:R-XTR-5358494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Xenopus tropicalis)
REACT:R-SPO-446200	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOLPP1 dephosphorylates DOLDP to DOLP (Schizosaccharomyces pombe)
GO:0140078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0140078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0140078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity
GO:0140078	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	AP endonuclease class I activity
GO:0140078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	class I DNA-(apurinic or apyrimidinic site) lyase activity
GO:0140078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP site-DNA 5'-phosphomonoester-lyase activity
RHEA:71585	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-histidine(out) + Na(+)(out) => L-histidine(in) + Na(+)(in)
REACT:R-BTA-111438	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Bos taurus)
GO:0031491	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nucleosome binding
RHEA:70308	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine
RHEA:29174	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a ubiquinol + 2 O2 <=> a ubiquinone + 2 H(+) + 2 superoxide
RHEA:71155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-caffeoylpyruvate + H2O = (E)-caffeate + H(+) + pyruvate
RHEA:17453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate
RHEA:17453	skos:altLabel	"phosphoribosylglycinamide synthetase"
RHEA:17453	skos:altLabel	"GAR synthetase"
RHEA:17453	skos:altLabel	"glycinamide ribonucleotide synthetase"
RHEA:17453	skos:prefLabel	"phosphoribosylamine--glycine ligase"
RHEA:17453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphoribosylamine--glycine ligase"
RHEA:17453	skos:altLabel	"GARS"
RHEA:51539	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP
REACT:R-MMU-8853686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Mus musculus)
REACT:R-HSA-110316	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Homo sapiens)
REACT:R-RNO-9024890	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Rattus norvegicus)
RHEA:65777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-GGA-9626848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Gallus gallus)
RHEA:53628	skos:prefLabel	"(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase"
RHEA:53628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase"
RHEA:53628	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate
REACT:R-DRE-5226999	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADD1:ADD3 binds DMTN (Danio rerio)
REACT:R-MMU-983266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins bind microtubules (Mus musculus)
REACT:R-HSA-1855205	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Homo sapiens)
REACT:R-RNO-9707353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP19A1 binds Aromatase inhibitors (Rattus norvegicus)
REACT:R-DDI-9647991	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Palmostatin B binds RAS depalmitoylases (Dictyostelium discoideum)
RHEA:43863	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)
RHEA:61945	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	24-methylenecholesterol + UDP-alpha-D-glucose => 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP
REACT:R-SPO-72671	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF5B:GTP is hydrolyzed and released (Schizosaccharomyces pombe)
REACT:R-XTR-3000399	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RANBP2 SUMOylates SP100 with SUMO1 (Xenopus tropicalis)
RHEA:30713	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-myrcene + H2O => (S)-linalool
REACT:R-XTR-9624120	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK2 (Xenopus tropicalis)
RHEA:34046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + neamine <=> 5''-phosphoribostamycin + diphosphate
REACT:R-CFA-983259	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Kinesins move along microtubules consuming ATP (Canis familiaris)
REACT:R-DDI-429497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLP-76 stimulates PLC gamma 2 (Dictyostelium discoideum)
GO:0005497	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	androgen binding
REACT:R-CFA-5654709	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
REACT:R-SSC-9727347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH dehydrogenates hypoxanthine to form xanthine (Sus scrofa)
REACT:R-RNO-8877692	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIN1 binds phosphorylated PIP4K2B (Rattus norvegicus)
REACT:R-RNO-8964242	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Rattus norvegicus)
REACT:R-XTR-351936	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of claspin (Xenopus tropicalis)
REACT:R-DRE-1605717	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Danio rerio)
REACT:R-CFA-1549526	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)
GO:0052811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphatidylinositol 3-phosphate 4-kinase activity
GO:0052811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-phosphatidylinositol-3-phosphate 4-kinase activity
GO:0052811	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 4-phosphotransferase activity
REACT:R-DRE-8850041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Danio rerio)
RHEA:71255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)
REACT:R-DDI-8951723	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Dictyostelium discoideum)
RHEA:28347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7,8-dihydroneopterin 3'-triphosphate => 7,8-dihydromonapterin 3'-triphosphate
RHEA:11086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + L-xylulose => 3-dehydro-L-gulonate + H(+)
RHEA:60480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 UTP = c-di-UMP + 2 diphosphate
REACT:R-HSA-977363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Factor H binds to C3bBb (Homo sapiens)
GO:0102188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity
REACT:R-SPO-9018787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB2 binds interacting proteins at the endosome membrane (Schizosaccharomyces pombe)
RHEA:60635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-4-oxoretinol + NAD(+) <=> all-trans-4-oxoretinal + H(+) + NADH
EC:2.4.1.366	skos:prefLabel	"ginsenoside F1 6-O-glucosyltransferase"
EC:2.4.1.366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ginsenoside F1 6-O-glucosyltransferase"
EC:2.4.1.366	skos:altLabel	"UGTPg101"
RHEA:37551	skos:prefLabel	"3-dehydro-glucose-6-phosphate--glutamate transaminase"
RHEA:37551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-D-glucose 6-phosphate + L-glutamate = 2-oxoglutarate + D-kanosamine 6-phosphate
RHEA:37551	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3-dehydro-glucose-6-phosphate--glutamate transaminase"
RHEA:37551	skos:altLabel	"3-oxo-glucose-6-phosphate:glutamate aminotransferase"
REACT:R-HSA-8950586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of glutathione S-transferase alpha 2 (Homo sapiens)
REACT:R-CEL-176606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)
RHEA:14070	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-fructose + NADP(+) => 5-dehydro-D-fructose + H(+) + NADPH
RHEA:68815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2Z,6E)-farnesyl diphosphate <=> beta-bisabolene + diphosphate
REACT:R-MMU-70589	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Mus musculus)
REACT:R-RNO-4085350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of UBE2I with SUMO1 (Rattus norvegicus)
RHEA:22948	skos:altLabel	"D-tagatose-1,6-bisphosphate aldolase"
RHEA:22948	skos:prefLabel	"tagatose-bisphosphate aldolase"
RHEA:22948	skos:altLabel	"D-tagatose-1,6-bisphosphate triosephosphate lyase"
RHEA:22948	skos:altLabel	"tagatose 1,6-diphosphate aldolase"
RHEA:22948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
RHEA:22948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"tagatose-bisphosphate aldolase"
REACT:R-RNO-199131	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PVR binds CD226 (Rattus norvegicus)
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aquacob(I)alamin adenosyltransferase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cob(I)yrinic acid a,c-diamide adenosyltransferase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP:cob(I)alamin Co-beta-adenosyltransferase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:cob(I)alamin cobeta-adenosyltransferase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	vitamin B12s adenosyltransferase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cob(II)yrinic acid a,c-diamide reductase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cob(I)alamin adenosyltransferase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	corrinoid adenosyltransferase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	aquocob(I)alamin vitamin B12s adenosyltransferase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:corrinoid adenosyltransferase activity
GO:0008817	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity
RHEA:66518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:51053	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5alpha-androstan-3,17-dione + A => 5alpha-androst-1-ene-3,17-dione + AH2
REACT:R-CFA-508163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Canis familiaris)
REACT:R-SSC-432010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Aquaporin-1 passively transports water into cell (Sus scrofa)
REACT:R-HSA-5339524	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)
RHEA:53772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chenodeoxycholate + lithocholoyl-CoA = chenodeoxycholoyl-CoA + lithocholate
GO:0004613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvic carboxykinase (GTP)
GO:0004613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate carboxylase (GTP)
GO:0004613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate carboxylase (GTP)
GO:0004613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP:oxaloacetate carboxy-lyase (transphosphorylating)
GO:0004613	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	phosphoenolpyruvic carboxykinase
GO:0004613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)
GO:0004613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphoenolpyruvic carboxylase (GTP)
GO:0004613	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phosphopyruvate (guanosine triphosphate) carboxykinase activity
GO:0004613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phosphoenolpyruvate carboxykinase (GTP) activity
RHEA:51830	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + docosanoate(out) + H(+)(out)
RHEA:33345	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-iminoacetate + H2O2 => glycine + O2
REACT:R-CFA-2730902	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oligomerization of p-CARMA1 (Canis familiaris)
GO:0034023	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	PurE
GO:0034023	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-CAIR mutase activity
GO:0034023	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	class I PurE
GO:0034023	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-(carboxyamino)imidazole ribonucleotide mutase activity
GO:0034023	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	N5-carboxyaminoimidazole ribonucleotide mutase activity
GO:0034023	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity
REACT:R-SSC-73815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)
REACT:R-SSC-444208	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MLNR (GPR38) is a receptor for motilin (Sus scrofa)
RHEA:60976	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + H(+) + NADH
REACT:R-MMU-9023632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)
REACT:R-HSA-200644	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Homo sapiens)
REACT:R-CFA-200423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Canis familiaris)
REACT:R-SSC-508162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Sus scrofa)
RHEA:32215	skos:prefLabel	"NAD(P)H-hydrate epimerase"
RHEA:32215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NAD(P)H-hydrate epimerase"
RHEA:32215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-NADHX = (6S)-NADHX
RHEA:32215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(6R)-NADPHX = (6S)-NADPHX
RHEA:32215	skos:altLabel	"NAD(P)HX epimerase"
RHEA:14027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NH4(+) + xanthopterin-B2 => H(+) + H2O + sepiapterin
REACT:R-GGA-205118	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TRAF6 polyubiquitinates NRIF (Gallus gallus)
RHEA:47487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	deoxycholate + NAD(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH
RHEA:53640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (-)-alpha-amorphene + diphosphate
RHEA:53640	skos:prefLabel	"(-)-alpha-amorphene synthase"
RHEA:53640	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"(-)-alpha-amorphene synthase"
REACT:R-SCE-6799350	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Exocytosis of specific granule membrane proteins (Saccharomyces cerevisiae)
REACT:R-BTA-77344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Bos taurus)
RHEA:36405	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + cholesterol + H(+) => a cholesterol ester + H2O
REACT:R-BTA-83586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)
RHEA:69141	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-(4-aminobutyl)-3-aminopropanal => acrolein + putrescine
RHEA:64819	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-aminolevulinate(in) <=> 5-aminolevulinate(out)
GO:0036238	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gallate dioxygenase activity
RHEA:63026	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(13Z)-docosenoate + NH4(+) => (13Z)-docosenamide + H2O
REACT:R-PFA-109529	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)
RHEA:52600	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-methionine + propanoyl-CoA = CoA + H(+) + N-propanoyl-L-methioninate
REACT:R-MMU-5668984	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PAK1 or PAK2 phosphorylates MYLK (Mus musculus)
RHEA:16241	skos:altLabel	"sucrose synthetase"
RHEA:16241	skos:altLabel	"UDP-glucose-fructose glucosyltransferase"
RHEA:16241	skos:prefLabel	"sucrose synthase"
RHEA:16241	skos:altLabel	"sucrose-uridine diphosphate glucosyltransferase"
RHEA:16241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + H(+) + sucrose
RHEA:16241	skos:altLabel	"sucrose-UDP glucosyltransferase"
RHEA:16241	skos:altLabel	"uridine diphosphoglucose-fructose glucosyltransferase"
RHEA:16241	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"sucrose synthase"
REACT:R-DDI-109700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT2 binds PIP3 (Dictyostelium discoideum)
RHEA:50784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH
REACT:R-MMU-2187388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Mus musculus)
REACT:R-MMU-8847537	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB43:GTP binds USP8NL (Mus musculus)
REACT:R-XTR-4332356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAMK2 binds MAP3K7 (Xenopus tropicalis)
RHEA:32363	skos:altLabel	"GLO"
RHEA:32363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"L-gulonolactone oxidase"
RHEA:32363	skos:prefLabel	"L-gulonolactone oxidase"
RHEA:32363	skos:altLabel	"L-gulono-gamma-lactone oxidase"
RHEA:32363	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-gulono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate
REACT:R-SSC-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)
GO:0140933	skos:prefLabel	"5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase"
GO:0140933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
GO:0140933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	m(7)GpppN-mRNA hydrolase activity
GO:0140933	skos:altLabel	"m(7)GpppN-mRNA hydrolase"
GO:0140933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP
GO:0140933	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase"
REACT:R-SSC-5082356	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSF1-mediated gene expression (Sus scrofa)
REACT:R-MMU-1855163	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Mus musculus)
REACT:R-SCE-192033	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Saccharomyces cerevisiae)
RHEA:15651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + NH4(+) => carbamate + 2 H(+)
REACT:R-XTR-1855193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Xenopus tropicalis)
RHEA:39550	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O
REACT:R-CEL-6806957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MET receptor dimerizes (Caenorhabditis elegans)
RHEA:44149	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-lysine => D-beta-lysine
RHEA:39660	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine
REACT:R-DRE-6799202	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Danio rerio)
REACT:R-DRE-975829	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Danio rerio)
RHEA:39321	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH
REACT:R-XTR-5649705	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Xenopus tropicalis)
REACT:R-HSA-9649736	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Homo sapiens)
REACT:R-BTA-209792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylation of serotonin (Bos taurus)
REACT:R-DME-188371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)
REACT:R-MMU-9681616	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AP2 binds chlorpromazine (Mus musculus)
RHEA:39815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O
RHEA:36375	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + carbamoyl phosphate + H2O = carbamoyl adenylate + diphosphate + phosphate
REACT:R-BTA-2466085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	at-retinyl is hydrolysed from R* to release atRAL (Bos taurus)
RHEA:38395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)
GO:0043873	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	NifJ
GO:0043873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate-flavodoxin oxidoreductase activity
GO:0043873	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	pyruvate:flavodoxin oxidoreductase activity
GO:0033769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity
GO:0033769	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing) activity
GO:0033769	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyceollin synthase activity
REACT:R-SSC-6799777	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 family members bind PPP1R13B or TP53BP2 (Sus scrofa)
RHEA:13219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + NADH + succinate => H2O + NAD(+) + succinate semialdehyde
GO:0033806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	fluorothreonine transaldolase activity
GO:0033806	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	fluoroacetaldehyde:L-threonine aldehydetransferase activity
REACT:R-CEL-435349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)
RHEA:59117	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[protein]-dithiol + O2 => [protein]-disulfide + H2O2
REACT:R-BTA-6804402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TP53 binds POU4F1 (Bos taurus)
REACT:R-DDI-8848484	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PLA2s hydrolyze phospholipids at the Golgi membrane (Dictyostelium discoideum)
RHEA:41677	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-hexadecyl-2-acetyl-sn-glycerol + ATP => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)
REACT:R-SSC-9009536	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DDX5 binds ESR1:estrogen:TFF1 gene promoter (Sus scrofa)
RHEA:33093	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+)
REACT:R-RNO-8932221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Rattus norvegicus)
REACT:R-MMU-193964	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP21A2 21-hydroxylates PROG (Mus musculus)
REACT:R-XTR-77615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Deamination at C6 position of adenosine in Editosome (ADAR2) (Xenopus tropicalis)
REACT:R-DRE-5618105	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Danio rerio)
RHEA:37388	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
REACT:R-RNO-9621179	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cinaciguat binds sGC:NO (Rattus norvegicus)
GO:0086020	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	gap junction channel activity involved in sinus node cell-atrial cardiomyocyte electrical coupling
GO:0086020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in SAN cell-atrial cardiomyocyte electrical coupling
GO:0086020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in SA node cell-atrial cardiomyocyte electrical coupling
GO:0086020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling
GO:0086020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gap junction channel activity involved in sinoatrial node cell-atrial cardiomyocyte electrical coupling
REACT:R-SPO-8851494	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NTPDase7 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)
RHEA:23440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H(+)
RHEA:23440	skos:prefLabel	"4-chlorobenzoate dehalogenase"
RHEA:23440	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"4-chlorobenzoate dehalogenase"
REACT:R-GGA-380586	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	loading of Serotonin in synaptic vesicles (Gallus gallus)
REACT:R-BTA-74737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)
REACT:R-XTR-9668395	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CHMP7 binds CC2D1B (Xenopus tropicalis)
REACT:R-DRE-9737780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTTP binds lomitapide (Danio rerio)
RHEA:29002	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+)(out) + homoserine lactone(in) <=> H(+)(in) + homoserine lactone(out)
RHEA:60081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)
REACT:R-GGA-8870678	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleaved fibrinogen products bind TLR4:LY96 (Gallus gallus)
RHEA:41617	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribose 2,5-bisphosphate + H2O => D-ribose 5-phosphate + phosphate
REACT:R-SPO-266012	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTD4 is converted to LTE4 by DPEP1/2 (Schizosaccharomyces pombe)
RHEA:35344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH
REACT:R-RNO-877361	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Pyrin binds ASC (Rattus norvegicus)
RHEA:12643	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phosphooxypyruvate + H(+) + NADH => (2R)-3-phosphoglycerate + NAD(+)
RHEA:70315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine
REACT:R-BTA-1482973	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Bos taurus)
REACT:R-SSC-5691108	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Sus scrofa)
RHEA:16473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"cyclohexane-1,3-dione hydrolase"
RHEA:16473	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H(+)
RHEA:16473	skos:prefLabel	"cyclohexane-1,3-dione hydrolase"
RHEA:66742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-glutamate(in)
RHEA:40307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + decanedioyl-CoA = (2E)-decenedioyl-CoA + AH2
REACT:R-HSA-9629470	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEIL3 cleaves 5-guanidinohydantoin (Homo sapiens)
REACT:R-BTA-68595	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ORC2 binds ORC3 (Bos taurus)
REACT:R-CEL-375487	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)
REACT:R-CFA-2161951	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)
RHEA:64100	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + TAN-1612
REACT:R-RNO-1222685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cathelicidin LL-37 binds to bacterial cell wall (Rattus norvegicus)
RHEA:12758	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dihydrozeatin + NADP(+) => H(+) + NADPH + zeatin
REACT:R-HSA-4551724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS4 SUMOylates HERC2 with SUMO1 (Homo sapiens)
RHEA:32344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-thujan-3-ol + NAD(+) => (+)-thujan-3-one + H(+) + NADH
REACT:R-DDI-994137	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Dictyostelium discoideum)
RHEA:72871	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	anthocyanin A3 + malonyl-CoA = anthocyanin A5 + CoA
RHEA:71704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	taurocholate(out) => taurocholate(in)
RHEA:24970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + 2 oxidized [adrenodoxin] + secalciferol => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]
RHEA:48276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine
REACT:R-XTR-204798	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interaction of Tie2 and p85 of PI3K (Xenopus tropicalis)
RHEA:10430	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2
REACT:R-HSA-382560	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABC7, mABC1 and mABC2 mediate heme transport (Homo sapiens)
GO:0005129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GM-CSF receptor binding
GO:0005129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GM-CSF receptor ligand
GO:0005129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte macrophage colony stimulating factor receptor binding
GO:0005129	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	granulocyte macrophage colony-stimulating factor receptor binding
GO:0005129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	GMC-SF receptor ligand
GO:0005129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	granulocyte macrophage colony-stimulating factor
GO:0005129	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	granulocyte macrophage colony-stimulating factor receptor ligand
REACT:R-DME-430183	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NCK binds PAK (Drosophila melanogaster)
REACT:R-RNO-1250462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)
RHEA:36989	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-ribose 1,5-bisphosphate + cytosine => CMP + phosphate
RHEA:67024	skos:prefLabel	"methyltransferase cap2"
RHEA:67024	skos:altLabel	"cap2-MTase"
RHEA:67024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine
RHEA:67024	skos:altLabel	"mRNA (nucleoside-2'-O)-methyltransferase"
RHEA:67024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"methyltransferase cap2"
REACT:R-SPO-209792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-acetylation of serotonin (Schizosaccharomyces pombe)
GO:0052668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	farnesol phosphotransferase activity
GO:0052668	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	farnesol kinase activity
GO:0052668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:2-trans,-6-trans-farnesol kinase activity
GO:0052668	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	trans,trans-farnesol kinase activity
GO:0052668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:2-trans,-6-trans-farnesol phosphotransferase activity
GO:0052668	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CTP:farnesol kinase activity
REACT:R-GGA-6781779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP13 deubiquitinates BECN1,USP10 (Gallus gallus)
REACT:R-SSC-216043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Collagen type II binds integrin alpha10beta1 (Sus scrofa)
REACT:R-SCE-77083	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Saccharomyces cerevisiae)
REACT:R-DRE-8874745	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Danio rerio)
REACT:R-GGA-266310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LCAT:spherical HDL complex <=> LCAT + spherical HDL (Gallus gallus)
RHEA:35548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]
REACT:R-MMU-2130194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL phosphorylates WAVEs (Mus musculus)
RHEA:30480	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]
REACT:R-RNO-5674019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BRAP binds KSR1:MARK3 (Rattus norvegicus)
REACT:R-DRE-9013533	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MPST transfers sulfur from sulfanegen to HCN to form HSCN (Danio rerio)
REACT:R-CFA-8850797	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SPINK6 binds KLK13 (Canis familiaris)
RHEA:67151	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 <=> 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]
REACT:R-DME-453342	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Drosophila melanogaster)
GO:0047655	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	allyl-alcohol:NADP+ oxidoreductase activity
GO:0047655	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	allyl-alcohol dehydrogenase activity
REACT:R-GGA-3928597	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	EPH:EFN dimers tetramerise (Gallus gallus)
REACT:R-DRE-8987161	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Danio rerio)
RHEA:58877	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-CEL-109527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)
GO:0097199	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	initiator caspase activity
GO:0097199	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	apical caspase activity
GO:0097199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type endopeptidase activity involved in apoptotic signalling pathway
GO:0097199	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	activator caspase activity
GO:0097199	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cysteine-type endopeptidase activity involved in apoptotic signaling pathway
REACT:R-CEL-8964634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Caenorhabditis elegans)
REACT:R-XTR-6800298	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HGF dimer binds MET (Xenopus tropicalis)
REACT:R-HSA-9008832	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 binds BAX gene promoter (Homo sapiens)
REACT:R-BTA-140823	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Bos taurus)
RHEA:13885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"stipitatonate decarboxylase"
RHEA:13885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + stipitatonate = CO2 + stipitatate
RHEA:13885	skos:prefLabel	"stipitatonate decarboxylase"
RHEA:56970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	dCDP + H(+) + phosphoenolpyruvate => dCTP + pyruvate
REACT:R-SSC-187949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAK-mediated phosphorylation of Cyclin A:Cdk2 (Sus scrofa)
RHEA:19619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine
REACT:R-CFA-4724284	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Canis familiaris)
REACT:R-CEL-2028697	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cleavage of p-STK3 (p-MST2) by caspase 3 (Caenorhabditis elegans)
RHEA:47548	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7alpha-hydroxy-3-oxochol-4-en-24-oate = 3-oxochola-4,6-dien-24-oate + H2O
RHEA:43211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine
REACT:R-BTA-4641155	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DVL1 is bound by the HECT ubiquitin ligase HECW1 (Bos taurus)
RHEA:67443	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(alpha)-acetyl-L-methionine <=> acetate + L-methionine
GO:1904492	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ac-Asp-Glu binding
REACT:R-MMU-193656	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p75NTR interacts with RIP2 (Mus musculus)
RHEA:58499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	choline + H(+) + NADH + O2 <=> glycolaldehyde + H2O + NAD(+) + trimethylamine
REACT:R-HSA-5696213	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AS3MT transfers CH3 from AdoMet to methylarsonite (Homo sapiens)
RHEA:23270	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycine + urea => guanidinoacetate + H2O
REACT:R-HSA-5663245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors (Homo sapiens)
RHEA:25809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + O2 + spermidine => 3-aminopropanal + H2O2 + putrescine
RHEA:61167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	kaempferol + UDP-beta-L-rhamnose <=> H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP
RHEA:31771	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
RHEA:32970	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine
REACT:R-CEL-8854041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF-FBXL7 ubiquitinates AURKA (Caenorhabditis elegans)
RHEA:28025	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + holo-[ACP] + octanoate <=> AMP + diphosphate + octanoyl-[ACP]
REACT:R-MMU-4641134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SMURF2 binds AXIN (Mus musculus)
RHEA:69368	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) = 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH
RHEA:44809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) => 2-demethylmenaquinol-10 + CO2 + diphosphate
GO:0003935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	guanosine triphosphate cyclohydrolase II
GO:0003935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP-8-formylhydrolase activity
GO:0003935	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTP cyclohydrolase II activity
GO:0003935	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GTP 7,8-8,9-dihydrolase (diphosphate-forming)
REACT:R-XTR-1675776	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Xenopus tropicalis)
RHEA:25448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = (+)-guaia-6,9-diene + diphosphate
GO:0106362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP
GO:0106362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	protein-arginine N-acetylglucosaminyltransferase activity
GO:0050177	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)
GO:0050177	skos:prefLabel	"phenylpyruvate decarboxylase"
GO:0050177	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	phenylpyruvate carboxy-lyase activity
GO:0050177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-phenylpyruvate + H(+) = 2-phenylacetaldehyde + CO2
GO:0050177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phenylpyruvate decarboxylase"
GO:0050177	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylpyruvate decarboxylase activity
GO:0050177	skos:altLabel	"phenylpyruvate carboxy-lyase"
REACT:R-RNO-9714691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAC3 binds ER effectors (Rattus norvegicus)
RHEA:52262	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a bacteriochlorophyllide e + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide c
RHEA:16780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + K(+)(out) <=> ADP + H(+) + K(+)(in) + phosphate
REACT:R-XTR-482772	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of platelet cytosolic components (Xenopus tropicalis)
REACT:R-CFA-192422	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Digestion of triacylglycerols by extracellular PTL:colipase (Canis familiaris)
EC:1.6.5.9	skos:altLabel	"NADH-CoQ reductase"
EC:1.6.5.9	skos:altLabel	"NADH-coenzyme Q reductase"
EC:1.6.5.9	skos:altLabel	"NADH-ubiquinone oxidoreductase"
EC:1.6.5.9	skos:altLabel	"electron transfer complex I"
EC:1.6.5.9	skos:altLabel	"NADH-coenzyme Q oxidoreductase"
EC:1.6.5.9	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"NADH:ubiquinone reductase (non-electrogenic)"
EC:1.6.5.9	skos:altLabel	"coenzyme Q reductase"
EC:1.6.5.9	skos:altLabel	"NADH2 dehydrogenase (ubiquinone)"
EC:1.6.5.9	skos:altLabel	"NADH-Q6 oxidoreductase"
EC:1.6.5.9	skos:altLabel	"NADH-CoQ oxidoreductase"
EC:1.6.5.9	skos:prefLabel	"NADH:ubiquinone reductase (non-electrogenic)"
EC:1.6.5.9	skos:altLabel	"NADH-ubiquinone reductase"
EC:1.6.5.9	skos:altLabel	"ubiquinone reductase"
REACT:R-GGA-5617815	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	BBSome binds RAB3IP (Gallus gallus)
REACT:R-CEL-8851632	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Caenorhabditis elegans)
REACT:R-CFA-9018499	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESR1:ESTG and EP300 are recruited to TFF3 promoter (Canis familiaris)
REACT:R-DRE-380905	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Serotonin loaded synaptic vesicle docking and priming (Danio rerio)
RHEA:59836	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate
REACT:R-MMU-373732	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Nephrin trans-homophilic interaction (Mus musculus)
REACT:R-SSC-1358792	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RNF41 ubiquitinates activated ERBB3 (Sus scrofa)
RHEA:49606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-glutathionyl-2-methylbut-3-enal + H(+) + NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+)
RHEA:30931	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-cysteine + O-acetyl-L-homoserine = acetate + H(+) + L,L-cystathionine
RHEA:25391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP(+))"
RHEA:25391	skos:altLabel	"3,4-dehydroadipyl-CoA semialdehyde dehydrogenase"
RHEA:25391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) = cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH
RHEA:25391	skos:prefLabel	"3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP(+))"
REACT:R-SSC-193711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
REACT:R-DRE-5662613	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MT3 exchanges zinc for copper (Danio rerio)
REACT:R-MMU-112392	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Resumption of elongation after recovery from pausing (Mus musculus)
RHEA:29785	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + L-cysteine(out) + phosphate => ATP + H2O + L-cysteine(in)
RHEA:13934	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	all-trans-retinyl hexadecanoate + H2O => all-trans-retinol + H(+) + hexadecanoate
RHEA:46257	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
REACT:R-XTR-1855219	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)
RHEA:63912	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-azauridine + ATP = 6-azauridine 5'-phosphate + ADP + H(+)
RHEA:26139	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine
RHEA:44362	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-2,4-dioxopentyl phosphate => (2S)-2-hydroxy-3,4-dioxopentyl phosphate
REACT:R-HSA-265153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Homo sapiens)
RHEA:48710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
RHEA:68457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-3-hydroxyglutaryl-CoA => (2E)-glutaconyl-CoA + H2O
REACT:R-SSC-2422927	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK3-3 or MAPK1 phosphorylate GORASP2 (Sus scrofa)
REACT:R-HSA-5138433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Homo sapiens)
REACT:R-SSC-5340195	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR1H4 binds DCA, CDCA, LCHA (Sus scrofa)
RHEA:37211	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2',3'-cyclophospho-GMP + H2O = guanosine 2'-monophosphate + H(+)
REACT:R-HSA-391266	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
RHEA:17601	skos:altLabel	"L-ribulokinase"
RHEA:17601	skos:prefLabel	"ribulokinase"
RHEA:17601	skos:prefLabel	"D-ribulokinase"
RHEA:17601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"ribulokinase"
RHEA:17601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)
RHEA:17601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate
RHEA:17601	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"D-ribulokinase"
RHEA:16294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-isopropylmaleate + H2O => (2S)-2-isopropylmalate
GO:0031682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-gamma protein subunit binding
GO:0031682	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	G-protein gamma-subunit binding
RHEA:66035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose
REACT:R-HSA-374173	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AGT(34-41) binds to AGTR1 (Homo sapiens)
REACT:R-RNO-199895	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RSK1/2/3 phosphorylates CREB at Serine 133 (Rattus norvegicus)
RHEA:16449	skos:altLabel	"6'-aminoglycoside-N-acetyltransferase"
RHEA:16449	skos:altLabel	"AAC(6')"
RHEA:16449	skos:altLabel	"kanamycin 6'-N-acetyltransferase"
RHEA:16449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"aminoglycoside 6'-N-acetyltransferase"
RHEA:16449	skos:prefLabel	"aminoglycoside 6'-N-acetyltransferase"
RHEA:16449	skos:altLabel	"aminoglycoside N(6')-acetyltransferase"
RHEA:16449	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B
REACT:R-SSC-9624112	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CEBPA binds CDK4 (Sus scrofa)
RHEA:29824	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chloride(in) => chloride(out)
RHEA:66110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate => 2-oxobutanoate + L-cysteine
RHEA:70982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-aminobutanoate(out) + n H(+)(in) <=> 4-aminobutanoate(in) + n H(+)(out)
RHEA:30381	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(+)-beta-chamigrene + diphosphate => (2E,6E)-farnesyl diphosphate
REACT:R-CFA-5690196	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP8 deubiquitinates RNF128 (Canis familiaris)
GO:0004370	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:glycerol-3-phosphotransferase activity
GO:0004370	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	GK
GO:0004370	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerokinase activity
GO:0004370	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glycerol kinase (phosphorylating)
GO:0004370	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	ATP:glycerol 3-phosphotransferase activity
GO:0004370	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol kinase activity
GO:0004370	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	glyceric kinase activity
REACT:R-CEL-1592371	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Initial activation of proMMP3 (Caenorhabditis elegans)
REACT:R-CFA-8852324	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GTSE1 binds PLK1 (Canis familiaris)
RHEA:16041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
REACT:R-HSA-68944	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
RHEA:10804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-allantoin = (R)-allantoin
RHEA:10804	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"allantoin racemase"
RHEA:10804	skos:prefLabel	"allantoin racemase"
REACT:R-BTA-9710106	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE cleaves GSDMD (Bos taurus)
REACT:R-GGA-8944254	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XXVI (Gallus gallus)
RHEA:42528	skos:prefLabel	"23S rRNA pseudouridine(955/2504/2580) synthase"
RHEA:42528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA
RHEA:42528	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"23S rRNA pseudouridine(955/2504/2580) synthase"
RHEA:56799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + cob(I)alamin-[corrinoid adenosyltransferase] <=> adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate
REACT:R-DRE-1067659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of hexameric IL-6 receptor (Danio rerio)
REACT:R-HSA-8851842	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MUC20 binds MET and inhibits GRB2 binding (Homo sapiens)
RHEA:71109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-leucine(in) + S-methylmercury-L-cysteine(out) => L-leucine(out) + S-methylmercury-L-cysteine(in)
GO:0070064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	proline-rich region binding
REACT:R-CEL-5218813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)
REACT:R-CFA-2002401	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XVIII (Canis familiaris)
REACT:R-XTR-111237	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Formation of ADAR1 homodimer (Xenopus tropicalis)
REACT:R-BTA-8876312	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Bos taurus)
REACT:R-BTA-193696	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Bos taurus)
RHEA:57452	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutaminyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine
GO:0008135	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	translation factor activity, nucleic acid binding
GO:0008135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation factor activity, RNA binding
REACT:R-RNO-9751024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC29A1,2 transport 6MP from extracellular region to cytosol (Rattus norvegicus)
REACT:R-MMU-8931981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX1 binds ESR1 (Mus musculus)
RHEA:40735	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(20S)-ginsenoside Rb1 + 2 H2O = 2 D-glucose + gypenoside LXXV
RHEA:66310	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose
REACT:R-BTA-6804253	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MDM2 ubiquitinates JMY (Bos taurus)
REACT:R-HSA-8858428	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FCAMR binds IgA (Homo sapiens)
RHEA:39624	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)
GO:0086041	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	voltage-gated potassium channel activity involved in sinus node cell action potential depolarization
GO:0086041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in sinoatrial node cell action potential depolarization
GO:0086041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in SA node cell action potential depolarization
GO:0086041	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	voltage-gated potassium channel activity involved in SAN cell action potential depolarization
REACT:R-DDI-5696021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPGK:Mg2+ phosphorylates Glc to G6P (Dictyostelium discoideum)
REACT:R-DRE-8869627	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NMRK2 phosphorylates NR to yield NMN (Danio rerio)
REACT:R-GGA-8855130	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Gallus gallus)
RHEA:34629	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin]
EC:2.3.1.176	skos:altLabel	"3-oxopristanoyl-CoA hydrolase"
EC:2.3.1.176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"propanoyl-CoA C-acyltransferase"
EC:2.3.1.176	skos:altLabel	"sterol carrier protein-chi"
EC:2.3.1.176	skos:altLabel	"sterol carrier protein-X"
EC:2.3.1.176	skos:altLabel	"PTE-2"
EC:2.3.1.176	skos:altLabel	"SCP-X"
EC:2.3.1.176	skos:prefLabel	"propanoyl-CoA C-acyltransferase"
EC:2.3.1.176	skos:altLabel	"propionyl-CoA C(2)-trimethyltridecanoyltransferase"
EC:2.3.1.176	skos:altLabel	"SCPchi"
EC:2.3.1.176	skos:altLabel	"3-oxopristanoyl-CoA thiolase"
EC:2.3.1.176	skos:altLabel	"peroxisomal thiolase 2"
RHEA:40206	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:60700	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1-acyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline
RHEA:51498	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a sphingoid 1-phosphate + ADP + H(+) => a sphingoid base + ATP
REACT:R-BTA-5626228	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The distal appendage proteins recruit TTBK2 (Bos taurus)
RHEA:54872	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(1S,4R)-menthone + H(+) + NADPH + O2 = (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)
RHEA:52485	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2
REACT:R-DME-68948	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)
REACT:R-CFA-964759	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Alternative endo-mannosidase I route (Canis familiaris)
RHEA:43267	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA <=> 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA
REACT:R-RNO-5358510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Rattus norvegicus)
RHEA:37032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribonate => 2-dehydro-3-deoxy-D-arabinonate + H2O
RHEA:11096	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH
REACT:R-CEL-912790	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CBL binds CRK (Caenorhabditis elegans)
REACT:R-HSA-9728150	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC5A2 binds gliflozins (Homo sapiens)
REACT:R-RNO-5618110	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Rattus norvegicus)
REACT:R-XTR-6800490	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates PIDD1 (Xenopus tropicalis)
REACT:R-RNO-6792445	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIPH, I hydrolyse PA to 2-acyl LPA (Rattus norvegicus)
REACT:R-RNO-8867654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PTPN3 binds p-T183,Y185 MAPK12 (Rattus norvegicus)
RHEA:55084	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-3-hydroxypentanoyl-CoA + H2O = (3R)-3-hydroxypentanoate + CoA + H(+)
REACT:R-SSC-76472	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ethylene is oxidized to Ethylene oxide by CYP1A1 (Sus scrofa)
REACT:R-HSA-9007686	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) (Homo sapiens)
EC:1.14.19.34	skos:prefLabel	"acyl-lipid (9+3)-(E)-desaturase"
EC:1.14.19.34	skos:altLabel	"acyl-lipid 12-(E)-desaturase"
EC:1.14.19.34	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acyl-lipid (9+3)-(E)-desaturase"
RHEA:37988	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	delta-tocopherol => 2-methyl-6-phytyl-1,4-benzene-1,4-diol
RHEA:68344	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + GTP = 3',2'-cGAMP + 2 diphosphate
REACT:R-GGA-1297354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acrosin Cleavage (Gallus gallus)
GO:0102289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	beta-amyrin 11-oxidase activity
REACT:R-DRE-8944233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Association of procollagen type XIX (Danio rerio)
RHEA:38078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA
REACT:R-RNO-8862184	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	USP48 cleaves polyubiquitin (Rattus norvegicus)
RHEA:55619	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a carotenoid psi-end group <=> a carotenoid epsilon-end group
RHEA:69146	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-guanidinobutanal + H2O2 + NH4(+) => agmatine + H2O + O2
RHEA:31864	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(S)-2,3-epoxysqualene => friedelin
REACT:R-DRE-193064	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSD17B3-like proteins reducde ANDST to TEST (Danio rerio)
REACT:R-SCE-71654	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Saccharomyces cerevisiae)
REACT:R-CEL-2160892	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Caenorhabditis elegans)
RHEA:66147	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-methoxytryptamine + acetyl-CoA <=> CoA + H(+) + melatonin
REACT:R-BTA-8871194	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB5 and GAPVD1 bind AP-2 (Bos taurus)
REACT:R-MMU-418176	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	F2R:ARRB2 binds MAPKs, SRC-1 (Mus musculus)
RHEA:10957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(E)-cinnamate + H(+) + NADPH + O2 => H2O + NADP(+) + trans-2-coumarate
RHEA:54982	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose
REACT:R-GGA-1250315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB4 homodimers (Gallus gallus)
REACT:R-HSA-2168881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Truncated Alpha-1-Microglobulin binds heme (Homo sapiens)
REACT:R-RNO-4085992	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of DAXX with SUMO1 (Rattus norvegicus)
REACT:R-CFA-917870	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC46A1 transports hemes from extracellular region to cytosol (Canis familiaris)
RHEA:66409	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O => ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate
REACT:R-GGA-3788075	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Brevican degradation by ADAMTS4, ADAMTS5 (Gallus gallus)
REACT:R-DRE-9755013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NME1,2 hexamers phosphorylate RBV-DP (Danio rerio)
REACT:R-CFA-2453876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TTR:RBP:atROL binds to STRA6 receptor (Canis familiaris)
REACT:R-RNO-5669024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CD70 binds CD27 (Rattus norvegicus)
REACT:R-SSC-420233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VIP receptors bind VIP (Sus scrofa)
RHEA:50085	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + taurolithocholate 3-sulfate(in) => ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)
RHEA:46476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
RHEA:25576	skos:prefLabel	"protoporphyrinogen oxidase"
RHEA:25576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX
RHEA:25576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"protoporphyrinogen oxidase"
RHEA:25576	skos:altLabel	"protoporphyrinogen IX oxidase"
RHEA:25576	skos:altLabel	"protoporphyrinogenase"
REACT:R-BTA-379415	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Bos taurus)
REACT:R-DRE-5638014	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Danio rerio)
RHEA:38789	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O
GO:0008766	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
RHEA:13569	skos:prefLabel	"N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase"
RHEA:13569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase"
RHEA:13569	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP
GO:0033458	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	aspartic acid tRNA
GO:0033458	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GAC codon-amino acid adaptor activity
REACT:R-PFA-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)
REACT:R-MMU-264615	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Loading of acetylcholine in synaptic vesicles (Mus musculus)
REACT:R-DRE-70670	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRODH oxidises L-Pro to 1PYR-5COOH (Danio rerio)
RHEA:19659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+)
REACT:R-BTA-5672966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Bos taurus)
GO:0140065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]
GO:0140065	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	protein butyryltransferase activity
GO:0140065	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptide butyryltransferase activity
RHEA:57347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-hydroxy-D-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine
RHEA:10135	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + benzoate + CoA <=> AMP + benzoyl-CoA + diphosphate
GO:0061608	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nuclear import signal receptor activity
GO:0061608	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	importin activity
RHEA:41637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + phosphate
RHEA:58634	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glyoxylate + tetradecamide => N-tetradecanoyl-(2S)-hydroxyglycine
GO:0047755	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity
GO:0047755	skos:prefLabel	"isocitrate epimerase"
GO:0047755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate = D-erythro-isocitrate
GO:0047755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"isocitrate epimerase"
GO:0047755	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isocitrate epimerase activity
REACT:R-SSC-8863721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NEDD8-STON binds TOR1 hexamer and COP9 complex (Sus scrofa)
REACT:R-BTA-173631	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of C1s (Bos taurus)
GO:0102981	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity
RHEA:20347	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	[thioredoxin]-disulfide + H(+) + NADPH => [thioredoxin]-dithiol + NADP(+)
REACT:R-CFA-390224	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Canis familiaris)
RHEA:63685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP => (4R,5S)-dethiobiotin + ADP + H(+) + phosphate
REACT:R-SSC-200326	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	creatine + ATP => phosphocreatine + ADP [CK octamer] (Sus scrofa)
RHEA:24689	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-formylmethanofuran <=> formate + methanofuran
RHEA:35835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2'-dehydrokanamycin A + H(+) + NADPH = kanamycin A + NADP(+)
RHEA:35835	skos:prefLabel	"2'-dehydrokanamycin reductase"
RHEA:35835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2'-dehydrokanamycin reductase"
GO:0008190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eIF4E binding
GO:0008190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	eukaryotic initiation factor 4E binding
RHEA:28086	skos:prefLabel	"dye decolorizing peroxidase"
RHEA:28086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H2O2 + Reactive Blue 5 = 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate
RHEA:28086	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"dye decolorizing peroxidase"
RHEA:28086	skos:altLabel	"DyP"
RHEA:28086	skos:altLabel	"DyP-type peroxidase"
REACT:R-CFA-8936584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)
RHEA:71391	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)
REACT:R-HSA-5685607	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Sialic acid binds SIGLEC (Homo sapiens)
RHEA:53813	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]
RHEA:24726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"N-demethylindolmycin N-methyltransferase"
RHEA:24726	skos:prefLabel	"N-demethylindolmycin N-methyltransferase"
RHEA:24726	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	N-demethylindolmycin + S-adenosyl-L-methionine = H(+) + indolmycin + S-adenosyl-L-homocysteine
RHEA:24366	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+)
RHEA:21019	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + L-asparagine <=> L-aspartate + NH4(+)
RHEA:18974	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-oxoglutarate + deacetoxyvindoline + O2 => 4-O-deacetylvindoline + CO2 + succinate
GO:1905538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polysome binding
GO:1905538	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	polyribosome binding
RHEA:29201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	menaquinol-8 + orotate => (S)-dihydroorotate + menaquinone-8
REACT:R-XTR-1297354	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Acrosin Cleavage (Xenopus tropicalis)
REACT:R-SSC-3249379	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S407-STAT6 is phosphorylated at Tyr641 (Sus scrofa)
REACT:R-HSA-8982637	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Opsins binds G alpha-t (Homo sapiens)
REACT:R-RNO-6805061	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CK2 binds FACT (Rattus norvegicus)
RHEA:35255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + lipid A-core(in) = ADP + H(+) + lipid A-core(out) + phosphate
RHEA:36968	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA
RHEA:17193	skos:altLabel	"inositol polyphosphate 4-phosphatase type II"
RHEA:17193	skos:prefLabel	"phosphatidylinositol-3,4-bisphosphate 4-phosphatase"
RHEA:17193	skos:altLabel	"inositol polyphosphate 4-phosphatase"
RHEA:17193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate
RHEA:17193	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"phosphatidylinositol-3,4-bisphosphate 4-phosphatase"
RHEA:17193	skos:altLabel	"D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase"
RHEA:17193	skos:altLabel	"inositol-3,4-bisphosphate 4-phosphatase"
RHEA:17193	skos:altLabel	"phosphoinositide 4-phosphatase"
RHEA:17380	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)
REACT:R-BTA-8980691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOA GEFs activate RHOA (Bos taurus)
REACT:R-DME-428676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Drosophila melanogaster)
REACT:R-RNO-1482612	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)
REACT:R-DRE-5696021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADPGK:Mg2+ phosphorylates Glc to G6P (Danio rerio)
REACT:R-HSA-77584	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Homo sapiens)
RHEA:45032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"hydroxylamine dehydrogenase"
RHEA:45032	skos:altLabel	"hydroxylamine oxidase"
RHEA:45032	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4 Fe(III)-[cytochrome c] + H2O + hydroxylamine = 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite
RHEA:45032	skos:altLabel	"hydroxylamine oxidoreductase"
RHEA:45032	skos:prefLabel	"hydroxylamine dehydrogenase"
REACT:R-CFA-9619024	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Canis familiaris)
REACT:R-HSA-1791082	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of Calreticulin (Homo sapiens)
RHEA:56188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
RHEA:56188	skos:altLabel	"core 6beta-GalNAc-transferase B"
RHEA:56188	skos:altLabel	"O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV"
RHEA:56188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase"
RHEA:56188	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP
RHEA:56188	skos:prefLabel	"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase"
RHEA:61821	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose => epiandrosterone 3-beta-D-glucoside + H(+) + UDP
REACT:R-SPO-9029434	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-S363,S380,T573 RS6K translocates to the nucleus (Schizosaccharomyces pombe)
REACT:R-MMU-76052	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Binding of TFIIIA To type 1 Promoter (Mus musculus)
REACT:R-HSA-8864433	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TFAP2A,TFAP2C homodimers stimulate CGA gene expression (Homo sapiens)
REACT:R-DME-390078	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	14-3-3 dimer binds to phosphorylated YKI (Drosophila melanogaster)
RHEA:30576	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3 menaquinone-8 + protoporphyrinogen IX => 3 menaquinol-8 + protoporphyrin IX
REACT:R-DRE-420233	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	VIP receptors bind VIP (Danio rerio)
REACT:R-XTR-202704	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Integrin alphaXbeta2 binds JAM3 (Xenopus tropicalis)
REACT:R-MMU-212269	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Mus musculus)
REACT:R-HSA-9656893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	OPN1MW binds 11cRAL (Homo sapiens)
REACT:R-CFA-5362721	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RDH5,RDH11 oxidise 11cROL to 11cRAL (Canis familiaris)
REACT:R-DRE-9018862	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)
GO:0090079	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	translation regulator activity, nucleic acid binding
REACT:R-DDI-446201	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PMM1,2 isomerise Man6P to Man1P (Dictyostelium discoideum)
RHEA:44289	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
RHEA:28044	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetyl-CoA + CO2 + NADH => CoA + NAD(+) + pyruvate
REACT:R-MMU-9706393	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RHOBTB3 binds ATP (Mus musculus)
REACT:R-XTR-191303	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FDPS dimer transfers IPPP to GPP (Xenopus tropicalis)
REACT:R-DRE-2309787	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Arachidonic acid is oxidised to PGG2 by PTGS2 (Danio rerio)
REACT:R-XTR-74885	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GUCYs converts GTP to cGMP (Xenopus tropicalis)
REACT:R-CEL-914006	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Caenorhabditis elegans)
REACT:R-MMU-1482598	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-acyl LPI is acylated to PI by MBOAT7 (Mus musculus)
REACT:R-MMU-158784	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Mus musculus)
REACT:R-DME-168162	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
REACT:R-RNO-1250315	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Trans-autophosphorylation of ERBB4 homodimers (Rattus norvegicus)
REACT:R-HSA-8870457	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FarC-PTP4A2 binds RABGGTB (Homo sapiens)
REACT:R-XTR-1226095	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Xenopus tropicalis)
REACT:R-CFA-392749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Transport of L1 into endosomes (Canis familiaris)
RHEA:30839	skos:prefLabel	"UDP-N-acetyl-L-fucosamine synthase"
RHEA:30839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"UDP-N-acetyl-L-fucosamine synthase"
RHEA:30839	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UDP-2-acetamido-2,6-dideoxy-beta-L-talose = UDP-N-acetyl-beta-L-fucosamine
RHEA:33462	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + NADPH + zymosterone <=> NADP(+) + zymosterol
GO:0030414	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	protease inhibitor activity
GO:0030414	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	peptidase inhibitor activity
RHEA:20806	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + hydrogencarbonate + NADH + propanoyl-CoA => 2-methyl-3-oxopropanoate + CoA + H2O + NAD(+)
GO:0022848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine-gated cation-selective channel activity
GO:0022848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine-activated cation-selective channel activity
GO:0022848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ionotropic acetylcholine receptor activity
GO:0022848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinic acetylcholine-activated cation-selective channel activity
GO:0022848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nAChR
GO:0022848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	nicotinergic acetylcholine receptor activity
GO:0022848	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acetylcholine-gated cation channel activity
REACT:R-CFA-8851859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated MET binds RANBP9 and SOS1 (Canis familiaris)
REACT:R-DRE-202453	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Auto-ubiquitination of TRAF6 (Danio rerio)
REACT:R-DME-8866553	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	misfolded CFTR is degraded by the 26S proteasome (Drosophila melanogaster)
REACT:R-CFA-5635859	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLI:SUFU dissociates (Canis familiaris)
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	arginine transmembrane transporter activity
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine(in) = L-arginine(out)
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	arginine-importing ATPase activity
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATPase-coupled L-arginine transmembrane transporter activity
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	L-arginine-importing ATPase activity
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine transporter activity
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-arginine transmembrane transporter activity
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	histidine/arginine/lysine/ornithine porter activity
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym	arginine permease activity
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	ATP-dependent L-arginine transmembrane transporter activity
GO:0061459	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	arginine porter activity
RHEA:65549	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ganglioside Fuc-GM1 + H2O => alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base
REACT:R-MMU-8852134	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	UBA1 adenylates ubiquitin in the cytosol (Mus musculus)
RHEA:34043	skos:prefLabel	"neamine phosphoribosyltransferase"
RHEA:34043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"neamine phosphoribosyltransferase"
RHEA:34043	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-phospho-alpha-D-ribose 1-diphosphate + neamine = 5''-phosphoribostamycin + diphosphate
RHEA:37641	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA
REACT:R-SCE-6811411	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GBF1 recruits ARF:GDP to the Golgi (Saccharomyces cerevisiae)
RHEA:25456	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,6E)-farnesyl diphosphate = diphosphate + gamma-humulene
RHEA:64893	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	holo-[ACP] + tetradecanoyl-AMP => AMP + H(+) + tetradecanoyl-[ACP]
REACT:R-HSA-9612255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ERBB4s80 binds ADAP1 gene (Homo sapiens)
REACT:R-HSA-6804276	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATM phosphorylates TTC5 (Homo sapiens)
REACT:R-DDI-70471	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Dictyostelium discoideum)
RHEA:39221	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxyoctacosanoyl-CoA + NADP(+) => 3-oxooctacosanyol-CoA + H(+) + NADPH
REACT:R-HSA-5660013	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Defective RPIA does not isomerize RU5P to R5P (Homo sapiens)
REACT:R-MMU-422104	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ghrelin O-acyltransferase octanoylates Proghrelin (Mus musculus)
REACT:R-CFA-5686587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ABL1 phosphorylates RAD52 (Canis familiaris)
REACT:R-SSC-9690534	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Sus scrofa)
RHEA:25916	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	A + H2O + quinolin-6-ol = 6-hydroxyquinolin-2(1H)-one + AH2
REACT:R-CEL-9705925	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Androgens binds AR (in the HSP90 chaperone complex) (Caenorhabditis elegans)
GO:0052596	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenethylamine:oxygen oxidoreductase (deaminating) activity
RHEA:50957	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine
REACT:R-CFA-6782227	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)
REACT:R-GGA-5357780	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)
REACT:R-HSA-5251959	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)
REACT:R-HSA-182876	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA (Homo sapiens)
REACT:R-RNO-2029454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Autophosphorylation of PAK1 (Rattus norvegicus)
RHEA:52795	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	chlorophyllide a + 2 H(+) <=> Mg(2+) + pheophorbide a
RHEA:68998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CO2 + gibberellin A4 + succinate => 2-oxoglutarate + gibberellin A9 + O2
REACT:R-CEL-1296348	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of TWIK-related K+ channel (TREK) (Caenorhabditis elegans)
RHEA:48508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cholate + NADP(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH
REACT:R-HSA-8987255	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Homo sapiens)
REACT:R-DDI-6814091	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ARL1 recruits TGN Golgin homodimers (Dictyostelium discoideum)
RHEA:43167	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	7-cyano-7-deazaguanine + guanosine(15) in tRNA <=> 7-cyano-7-carbaguanosine(15) in tRNA + guanine
REACT:R-HSA-9036987	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Homo sapiens)
REACT:R-XTR-873924	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IFNGR1 by JAK kinases (Xenopus tropicalis)
GO:0097642	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	calcitonin family receptor activity
REACT:R-CEL-3928651	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NGEF exchanges GTP for GDP on RHOA (Caenorhabditis elegans)
REACT:R-RNO-110349	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Displacement of UNG glycosylase by APEX1 at the AP site (Rattus norvegicus)
REACT:R-HSA-9007561	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	E2F1 binds RAD51 gene promoter (Homo sapiens)
REACT:R-SSC-201611	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of Rock-1 (Sus scrofa)
REACT:R-MMU-198513	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 (Mus musculus)
RHEA:51816	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)
RHEA:14225	skos:prefLabel	"6-hydroxyhexanoate dehydrogenase"
RHEA:14225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH
RHEA:14225	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"6-hydroxyhexanoate dehydrogenase"
REACT:R-CFA-6781953	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	YOD1 binds VCP (Canis familiaris)
RHEA:46835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
REACT:R-RNO-202939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-mediated cleavage of E-Cadherin (Rattus norvegicus)
REACT:R-HSA-3465448	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
REACT:R-HSA-9010190	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ROBO3 binds NELL2 (Homo sapiens)
REACT:R-CFA-6783939	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)
REACT:R-GGA-5578744	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Importin-8 imports AGO2:miRNA into the nucleus (Gallus gallus)
RHEA:70245	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-xylose
RHEA:11478	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glycerol + phosphate => glycerol 1-phosphate + H2O
REACT:R-BTA-8987097	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Bos taurus)
RHEA:45812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"
RHEA:45812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O
RHEA:45812	skos:prefLabel	"very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"
REACT:R-MMU-75869	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Mus musculus)
REACT:R-CFA-3149563	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Canis familiaris)
RHEA:64746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-sulfanyl-1-hexanol + NH4(+) + pyruvate => H2O + S-3-(hexan-1-ol)-L-cysteine
RHEA:25854	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2
REACT:R-RNO-6813659	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ELANE, CTSG or PRTN3 binds bacteria (Rattus norvegicus)
REACT:R-SPO-5651805	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIG1 bound to APEX1 and PCNA ligates SSB (Schizosaccharomyces pombe)
REACT:R-DME-73577	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)
EC:1.98.-.-	skos:prefLabel	"Enzymes using H2 as reductant"
EC:1.98.-.-	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Enzymes using H2 as reductant"
REACT:R-CFA-3697894	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PRDX5 reduces peroxynitrite to nitrite using TXN2 (Canis familiaris)
REACT:R-MMU-110364	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)
GO:0016742	skos:prefLabel	"Hydroxymethyl-, formyl- and related transferases"
GO:0016742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Hydroxymethyl-, formyl- and related transferases"
GO:0016742	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	hydroxymethyl-, formyl- and related transferase activity
RHEA:37691	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
RHEA:26306	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-aminophenol + O2 => 2-aminomuconate 6-semialdehyde
REACT:R-DRE-388503	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Oxytocin receptor bind oxytocin (Danio rerio)
REACT:R-HSA-3149518	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MTRR reduces cob(II)alamin to meCbl (Homo sapiens)
REACT:R-MMU-9756180	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Mus musculus)
RHEA:11937	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + trans-resveratrol
RHEA:39081	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-oxododecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydodecanedioyl-CoA + NAD(+)
REACT:R-RNO-1013020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activation of GIRK/Kir3 Channels (Rattus norvegicus)
REACT:R-RNO-4085296	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SUMOylation of NCOA1 with SUMO1 (Rattus norvegicus)
REACT:R-XTR-69068	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RFC dissociates after sliding clamp formation (Xenopus tropicalis)
REACT:R-HSA-2399985	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AKT1 E17K mutant phosphorylates caspase-9 (Homo sapiens)
REACT:R-MMU-70377	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Mus musculus)
REACT:R-SSC-187575	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ubiquitination of phospho-p27/p21 (Sus scrofa)
RHEA:48574	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2E,4E)-2,4-dichloromuconate + 2 H(+) => 3,5-dichlorocatechol + O2
REACT:R-RNO-1855214	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Rattus norvegicus)
RHEA:62009	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)
RHEA:72647	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,6-dihydroxyphenazine + NADPH + O2 = 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)
REACT:R-HSA-1989752	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of TXNRD1 (Homo sapiens)
REACT:R-BTA-167419	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	The receptor:G-protein complex releases GDP (Bos taurus)
GO:0102313	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1,8-cineole synthase activity
RHEA:48076	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a primary alcohol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde
REACT:R-DME-209332	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LGS dissociates from the PYGO complex (Drosophila melanogaster)
RHEA:47510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	isolithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH
REACT:R-XTR-427998	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Proton-coupled di- and tri-peptide cotransport (Xenopus tropicalis)
REACT:R-MMU-4420153	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p-6Y-VEGFR2 binds PLCG1 (Mus musculus)
GO:0071855	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	neuropeptide receptor binding
REACT:R-HSA-448703	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
REACT:R-CFA-6814676	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SNAPs and NSF hexamer bind cis-SNARE at the TGN (Canis familiaris)
RHEA:59286	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-glucose + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O
RHEA:30525	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GDP + H(+) + oxidized coenzyme F420-2 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-1
RHEA:35558	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid
REACT:R-SSC-914010	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Sus scrofa)
REACT:R-GGA-1912394	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NICD1 in complex with RBPJ (CSL) recruits MAML (Gallus gallus)
RHEA:21602	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CoA + N-benzoylanthranilate => anthranilate + benzoyl-CoA
RHEA:31329	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+) => 1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol
REACT:R-SSC-6787820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL34 dimer binds CSF1R (Sus scrofa)
REACT:R-RNO-420724	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CASR binds Ca2+ (Rattus norvegicus)
REACT:R-HSA-9692154	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SOX9 binds the PTGDS gene (Homo sapiens)
REACT:R-HSA-9604294	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Gamma-secretase cleaves NOTCH4 (Homo sapiens)
REACT:R-SSC-448421	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Interleukin-27 translocates from the ER lumen to the extracellular region (Sus scrofa)
REACT:R-RNO-5610746	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF(beta-TrCP) ubiquitinates p-GLI3 (Rattus norvegicus)
GO:0047508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
GO:0047508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citraconase activity
GO:0047508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(-)-citramalate hydro-lyase activity
GO:0047508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citraconate hydratase activity
GO:0047508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	(R)-2-methylmalate hydro-lyase activity
GO:0047508	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	citramalate hydro-lyase activity
GO:0047508	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(R)-2-methylmalate dehydratase activity
RHEA:23635	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-threo-isocitrate + NAD(+) <=> 2-oxoglutarate + CO2 + NADH
RHEA:20124	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + L-glutamine + tRNA(Gln) <=> AMP + diphosphate + L-glutaminyl-tRNA(Gln)
REACT:R-XTR-909738	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHP1 and SHP2 bind the common beta chain (Xenopus tropicalis)
REACT:R-CFA-5362386	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Glycosylation of Hh (Canis familiaris)
REACT:R-MMU-74258	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	XDH oxidizes xanthine to form urate (Mus musculus)
RHEA:17874	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an R-cob(III)alamin(out) + ATP + H2O => ADP + an R-cob(III)alamin(in) + H(+) + phosphate
REACT:R-DRE-4615900	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PIAS1 SUMOylates SATB2 with SUMO3 (Danio rerio)
GO:0008847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"Enterobacter ribonuclease"
GO:0008847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enterobacter ribonuclease activity
GO:0008847	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Enterobacter RNase activity
GO:0008847	skos:prefLabel	"Enterobacter ribonuclease"
REACT:R-RNO-70606	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Rattus norvegicus)
RHEA:56000	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)
REACT:R-BTA-9634169	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	POM121 and NDC1 bind the Nup93 complex (Bos taurus)
GO:0044374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	sequence-specific DNA binding, bending
GO:0044374	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DNA bending involving sequence-specific DNA binding
RHEA:33666	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine
GO:0102189	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity
RHEA:53532	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate = (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O
REACT:R-MMU-912527	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
RHEA:29587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase"
RHEA:29587	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH
RHEA:29587	skos:prefLabel	"2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase"
RHEA:29587	skos:altLabel	"4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase"
REACT:R-MMU-199216	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix (Mus musculus)
RHEA:54003	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate
REACT:R-SSC-74711	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of IRS (Sus scrofa)
REACT:R-XTR-5357928	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLIP3 and CYLD bind TNF signaling complex (Xenopus tropicalis)
REACT:R-DRE-450337	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
REACT:R-GGA-9659820	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RB1 translocates to the nucleus (Gallus gallus)
REACT:R-HSA-9032761	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	DOCK3 binds FYN associated with NTRK2 (Homo sapiens)
RHEA:64319	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 dihydrogeodin + 2 H(+) + O2 <=> 2 (+)-geodin + 2 H2O
RHEA:64132	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine
REACT:R-HSA-2168887	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Ferriheme is transferred from Albumin to Hemopexin (Homo sapiens)
RHEA:69812	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
REACT:R-GGA-72622	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Release of eIF4E from the inactive eIF4E:4E-BP complex  (Gallus gallus)
GO:0102799	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	glucosinolate glucohydrolase activity
REACT:R-MMU-1363311	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)
GO:0005046	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	KDEL sequence binding
GO:0005046	http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym	KDEL receptor activity
REACT:R-SCE-5687109	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MAPK4,6 translocate to the cytoplasm (Saccharomyces cerevisiae)
RHEA:30825	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine
REACT:R-HSA-1454781	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Homo sapiens)
REACT:R-SSC-9036307	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GPER:Heterotrimeric G-protein Gs binds ESTG (Sus scrofa)
REACT:R-CFA-5668454	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)
REACT:R-RNO-2032396	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Dimerized phospho-IRF3 migrates to the nucleus (Rattus norvegicus)
REACT:R-CFA-1855165	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
REACT:R-DRE-164423	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	PhosphoChREBP (Thr 666)  is exported to cytosol (Danio rerio)
RHEA:28710	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cd(2+)(in) <=> Cd(2+)(out)
REACT:R-SPO-5682020	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	MRN complex binds shortened telomeres (Schizosaccharomyces pombe)
RHEA:55035	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	an N-methylornithine lipid + S-adenosyl-L-methionine <=> an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine
RHEA:39402	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O
REACT:R-BTA-9717215	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Bos taurus)
REACT:R-HSA-1791186	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Expression of ZBTB17 (Homo sapiens)
REACT:R-CFA-187520	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Canis familiaris)
REACT:R-GGA-75809	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Phosphorylation of Cdc25C at Ser216 by CHEK2 (Gallus gallus)
RHEA:36119	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	gibberellin A9 + S-adenosyl-L-methionine = O-methyl gibberellin A9 + S-adenosyl-L-homocysteine
REACT:R-MMU-6793591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Mus musculus)
REACT:R-HSA-9664881	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Homo sapiens)
REACT:R-SSC-1112510	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IL6ST is tyrosine phosphorylated (Sus scrofa)
RHEA:60966	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose
RHEA:53502	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O
REACT:R-MMU-5621353	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Mus musculus)
RHEA:11275	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	a (2R)-2-hydroxycarboxylate + a quinone <=> a 2-oxocarboxylate + a quinol
RHEA:37272	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + H2O + L-alanyl-L-glutamine(out) => ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate
RHEA:19357	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	H(+) + L-proline betaine + NADPH + O2 = formaldehyde + H2O + N-methyl-L-proline + NADP(+)
REACT:R-BTA-110145	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AMP + ATP <=> ADP + ADP [AK2] (Bos taurus)
GO:1903089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	acadesine transporter activity
GO:1903089	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity
RHEA:51244	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(9Z,12Z,15Z)-octadecatrienoate + O2 = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
RHEA:27476	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATP + D-glycero-beta-D-manno-heptose 7-phosphate <=> ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)
REACT:R-CFA-9696268	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	RND3 binds effectors (Canis familiaris)
REACT:R-BTA-5684248	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
RHEA:71027	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	L-glutamine(in) + L-phenylalanine(out) = L-glutamine(out) + L-phenylalanine(in)
RHEA:25737	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]
REACT:R-SPO-113504	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Detection of damage during initiation of DNA synthesis in S-phase (Schizosaccharomyces pombe)
RHEA:24376	skos:prefLabel	"biotin--[methylcrotonoyl-CoA-carboxylase] ligase"
RHEA:24376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
RHEA:24376	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	"biotin--[methylcrotonoyl-CoA-carboxylase] ligase"
RHEA:24376	skos:altLabel	"biotin--[methylcrotonoyl-CoA-carboxylase] synthetase"
RHEA:47653	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	D-ribitol 1-phosphate + H2O => phosphate + ribitol
RHEA:35716	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	(2S,3S)-versiconal hemiacetal acetate + H2O => (2S-3S)-versiconal hemiacetal + acetate + H(+)
REACT:R-RNO-9724685	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	IgE binds omalizumab (Rattus norvegicus)
REACT:R-CFA-5624949	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Assembly of the anterograde IFT train (Canis familiaris)
REACT:R-HSA-5610749	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	cAMP dissociates PKA, promoting GLI processing (Homo sapiens)
REACT:R-DDI-9709547	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ESTG binds ESR2:chaperone complex (Dictyostelium discoideum)
REACT:R-CEL-428779	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	GLUT7 and GLUT11 transport glucose and fructose (Caenorhabditis elegans)
REACT:R-BTA-893593	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Bos taurus)
REACT:R-RNO-421835	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	trans-Golgi Network Vesicle Scission (Rattus norvegicus)
REACT:R-SSC-8952618	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Sus scrofa)
GO:0101021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	estrogen 2-hydroxylase activity
GO:0101021	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	oestrogen 2-hydroxylase activity
REACT:R-BTA-1482646	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	2-acyl LPE is acylated to PE by LPEAT (Bos taurus)
RHEA:69808	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	benzoyl-AMP + CoA => AMP + benzoyl-CoA + H(+)
GO:0047664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminoimidazole aminohydrolase activity
GO:0047664	http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym	4-aminoimidazole hydrolase activity
GO:0047664	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	aminoimidazolase activity
REACT:R-GGA-5683588	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ATG10 transfers ATG12 from ATG10 to ATG5 (Gallus gallus)
RHEA:66178	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out) => ATP + H2O + taurochenodeoxycholate 3-sulfate(in)
REACT:R-SSC-429571	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Sus scrofa)
RHEA:16591	http://www.geneontology.org/formats/oboInOwl#hasExactSynonym	3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2 => A + sucrose